PMID- 42958883 OWN - NLM STAT- MEDLINE DCOM- 20261030 LR - 20261030 IS - 2045-7634 (Electronic) IS - 2045-7634 (Linking) VI - 15 IP - 11 DP - 2026 Nov TI - Quality Indicators in End-of-Life Care for Children With Cancer in Low- and Middle-Income Countries. LID - e72443 [pii] LID - 10.1002/cam4.72443 [doi] AB - BACKGROUND: Around 90% of children with cancer live in low- and middle-income countries (LMICs), with the majority dying of their disease. Despite the need for quality end-of-life (EoL) care in LMICs, access and integration remain limited. Quality indicators (QIs) can assess and provide standards for high-quality care. The aim of this study was to develop QIs for EoL care for children diagnosed with cancer in LMICs. METHODS: The QIs were identified and prioritized through a multi-phase process: (1) literature review identified potential QIs from existing guidelines, standards, and published studies; (2) modified Delphi approach engaged global experts to assess the importance and feasibility of QIs; and (3) prioritization conducted using a Discrete Choice Experiment (DCE) with experts and dot voting prioritization exercise with bereaved family members. RESULTS: From the literature review, 73 potential QIs were identified. Fifty-six global experts from 27 countries participated in the modified Delphi. Sixty-four indicators across seven domains were deemed important with 25 identified as both important and feasible. Forty-one global experts from 23 countries participated in the DCE prioritization and 12 bereaved family members from nine countries participated in the dot voting prioritization. While experts and family members prioritized some indicators similarly (i.e., symptom management), family members placed higher priority on QIs addressing communication and anticipatory guidance. CONCLUSION: This study describes a robust, context-specific process which identified QIs for pediatric EoL care in LMICs. Future efforts will pilot and refine the QIs to demonstrate feasibility, sustainability, and impact on care quality. PRECIS: This study assessed potential quality indicators (QIs) for pediatric end-of-life (EoL) care in low- and middle-income countries (LMICs) through a multi-phase process involving global experts and bereaved families. The findings provide a set of potential QIs to evaluate and improve EoL care for children with cancer in LMICs. CI - (c) 2026 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd. FAU - McNeil, Michael J AU - McNeil MJ AUID- ORCID: 0000-0001-8817-1995 AD - Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. AD - Division of Quality of Life and Palliative Care, Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Quintero, Ximena Garcia AU - Quintero XG AUID- ORCID: 0000-0003-1416-544X AD - Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Salek, Marta AU - Salek M AUID- ORCID: 0000-0002-3421-5945 AD - Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. AD - Division of Quality of Life and Palliative Care, Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Agulnik, Asya AU - Agulnik A AUID- ORCID: 0000-0001-8932-8181 AD - Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Downing, Julia AU - Downing J AUID- ORCID: 0000-0002-3450-785X AD - International Children's Palliative Care Network, Cape Town, South Africa. FAU - Dussel, Veronica AU - Dussel V AUID- ORCID: 0000-0002-9259-6133 AD - Pediatric Palliative Care Research, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Friedrich, Paola AU - Friedrich P AUID- ORCID: 0000-0002-5265-3113 AD - Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Garcia, Wendy Gomez AU - Garcia WG AD - Dr. Robert Reid Cabral Children's Hospital, Santo Domingo, Dominican Republic. FAU - Johnston, Emily E AU - Johnston EE AUID- ORCID: 0000-0001-9126-2169 AD - Division of Pediatric Hematology-Oncology, Department of Pediatrics, University of Alabama at Birmingham School of Medicine, Institute for Cancer Outcomes and Survivorship, UAB School of Medicine, Birmingham, Alabama, USA. FAU - Movsisyan, Narine AU - Movsisyan N AUID- ORCID: 0000-0002-0258-9002 AD - Yerevan State Medical University After Mkhitar Heratsi, Yerevan, Armenia. FAU - Namisango, Eve AU - Namisango E AUID- ORCID: 0000-0001-5032-4714 AD - African Palliative Care Association, Kampala, Uganda. FAU - Rao, Krithika AU - Rao K AUID- ORCID: 0000-0002-7679-4850 AD - Department of Palliative Medicine and Supportive Care, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. FAU - Sansom-Daly, Ursula M AU - Sansom-Daly UM AUID- ORCID: 0000-0003-4200-8900 AD - Behavioural Sciences Unit, School of Clinical Medicine, UNSW Medicine & Health, Discipline of Paediatrics and Child Health, UNSW Sydney, Sydney, New South Wales, Australia. AD - Kids Cancer Centre, Sydney Children's Hospital, Randwick, New South Wales, Australia. AD - Sydney Youth Cancer Centre, Nelune Comprehensive Cancer Centre, Prince of Wales Hospital, Randwick, New South Wales, Australia. FAU - Widger, Kimberley AU - Widger K AUID- ORCID: 0000-0001-8132-061X AD - Lawrence Bloomberg Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada. FAU - Wiener, Lori AU - Wiener L AUID- ORCID: 0000-0002-9573-8870 AD - National Institutes of Health, Bethesda, Maryland, USA. FAU - Rodriguez-Galindo, Carlos AU - Rodriguez-Galindo C AUID- ORCID: 0000-0002-2360-8946 AD - Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Baker, Justin N AU - Baker JN AUID- ORCID: 0000-0002-6584-6483 AD - Division of Quality of Life and Pediatric Palliative Care, Stanford University, Palo Alto, California, USA. LA - eng GR - 2023GOYIA-0927762799/Conquer Cancer Foundation/ GR - American Lebanese Syrian Associated Charities/ PT - Journal Article PL - United States TA - Cancer Med JT - Cancer medicine JID - 101595310 SB - IM MH - Humans MH - *Terminal Care/standards MH - *Quality Indicators, Health Care MH - Developing Countries MH - *Neoplasms/therapy MH - Child MH - Resource-Limited Settings MH - Delphi Technique OTO - NOTNLM OT - bereaved families OT - end-of-life care OT - health equity OT - low- and middle-income countries OT - pediatric oncology OT - pediatric palliative care OT - quality indicators EDAT- 2026/10/30 05:31 MHDA- 2026/10/30 05:32 CRDT- 2026/10/30 03:13 PHST- 2026/10/30 05:32 [medline] PHST- 2026/10/30 05:31 [pubmed] PHST- 2026/10/07 00:00 [revised] PHST- 2026/06/03 00:00 [received] PHST- 2026/10/21 00:00 [accepted] PHST- 2026/10/30 03:13 [entrez] AID - e72443 [pii] AID - 10.1002/cam4.72443 [doi] PST - ppublish SO - Cancer Med. 2026 Nov;15(11):e72443. doi: 10.1002/cam4.72443. PMID- 42958216 OWN - NLM STAT- MEDLINE DCOM- 20261030 LR - 20261030 IS - 1472-6874 (Electronic) IS - 1472-6874 (Linking) VI - 26 IP - 1 DP - 2026 Jul 28 TI - Physical activity and health-related quality of life in women with polycystic ovary syndrome attending fertility clinics in Sri Lanka: a cross-sectional study. LID - 567 [pii] LID - 10.1186/s12905-026-04742-2 [doi] AB - BACKGROUND: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder that substantially impairs health-related quality of life (HRQoL). Regular physical activity is a recommended first-line intervention, but the relationship between activity and HRQoL is understudied in South Asian women, particularly in those attending fertility clinics who carry the additional psychological burden of infertility. This study aimed to examine the association between physical activity levels and PCOS-specific HRQoL in women with PCOS attending fertility clinics in Colombo, Sri Lanka. METHODS: An analytical cross-sectional study was conducted at the fertility clinics of two tertiary care hospitals in Colombo, Sri Lanka: De Soysa Hospital for Women and Children and Castle Street Hospital for Women between 13 October and 7 November 2025. Eighty-five women aged 18-45 years with a clinician-confirmed diagnosis of PCOS were recruited by convenience sampling. Physical activity was assessed using the International Physical Activity Questionnaire - Short Form (IPAQ-SF), validated to the Sri Lankan setting, and expressed as MET-minutes per week. HRQoL was measured using the Polycystic Ovary Syndrome Questionnaire (PCOSQ), validated in the Sri Lankan setting, which yields a total score and five domain scores (emotions, body hair, weight, infertility, menstrual problems) on a 1-7 scale, with higher scores indicating better HRQoL. PCOS phenotype was classified according to the Rotterdam criteria. Continuous variables were summarized using medians and interquartile ranges, and Spearman's rank correlation (r(s)) was used to examine the association between physical activity and HRQoL. RESULTS: The mean (SD) age was 28.0 (4.9) years, and the median (IQR) age was 28 (24-30) years; the median body mass index was 30.2 (28.0-32.4) kg/m(2). The majority of participants (60.0%, n = 51) were classified as having low physical activity, with a median total activity score of 1017.0 (569.5-2459.3) MET-minutes/week. The median overall PCOSQ score was 3.07 (2.37-3.64), indicating moderate HRQoL impairment; the lowest-scoring domain was body hair and appearance (median 2.20), and the highest was infertility-related worries (median 3.50). Physical activity showed a statistically significant moderate positive correlation with overall HRQoL (r(s) = 0.465, p < 0.001). Domain-specific analyses revealed significant moderate positive correlations with emotional well-being (r(s) = 0.493, p < 0.001), weight (r(s) = 0.470, p < 0.001) and infertility (r(s) = 0.464, p < 0.001) domains, while body hair (r(s) = 0.210, p = 0.054) and menstrual symptoms (r(s) = - 0.027, p = 0.805) were not significantly associated. Phenotype-stratified analyses showed significant associations in Phenotype A (r(s) = 0.384, p = 0.004) and Phenotype B (r(s) = 0.490, p = 0.015); Phenotypes C (n = 2) and D (n = 4) were underpowered. CONCLUSIONS: In this cross-sectional sample, higher physical activity levels were associated with better overall PCOS-specific quality of life among women attending fertility clinics in Colombo, with the strongest domain-specific associations observed for emotional well-being, weight, and infertility-related concerns. Because the design was cross-sectional, causality cannot be inferred. Nonetheless, given that sixty per cent of participants did not meet recommended activity levels, these findings support routinely assessing physical activity in fertility clinic care and suggest that physical activity may be a useful target for future longitudinal and interventional studies of HRQoL in women with PCOS in Sri Lanka. CI - (c) 2026. The Author(s). FAU - Lakshan, G A R AU - Lakshan GAR AD - Department of Allied Health Sciences, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. FAU - Rishard, Mohamed AU - Rishard M AD - Department of Obstetrics and Gynecology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. mrishard@obg.cmb.ac.lk. LA - eng PT - Journal Article DEP - 20260728 PL - England TA - BMC Womens Health JT - BMC women's health JID - 101088690 SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/psychology MH - *Quality of Life/psychology MH - Sri Lanka MH - Cross-Sectional Studies MH - Adult MH - *Exercise/psychology MH - Adolescent MH - Young Adult MH - Surveys and Questionnaires MH - Middle Aged MH - Infertility, Female/psychology OAB - Polycystic ovary syndrome (PCOS) is a common hormonal condition in women of reproductive age that can cause irregular periods, difficulty becoming pregnant, weight gain, and unwanted hair growth, and it often affects women's day-to-day well-being. We asked eighty-five women with PCOS who were attending fertility clinics at two hospitals in Colombo, Sri Lanka, how physically active they were and how the condition was affecting their quality of life. 60% of the women were not doing enough physical activity to meet international recommendations, and most reported moderately reduced quality of life, with concerns about body hair and appearance and weight affecting them the most. Women who were more physically active reported better overall quality of life, better emotional well-being, fewer weight-related concerns, and less infertility-related distress. These findings suggest that asking women with PCOS about physical activity and helping them to be more active could be a simple and low-cost way for fertility clinics in Sri Lanka to improve patients' wellbeing alongside the medical treatment they are already receiving. OABL- eng OTO - NOTNLM OT - Fertility clinic OT - IPAQ-SF OT - PCOSQ OT - Physical activity OT - Polycystic ovary syndrome OT - Polyendocrine metabolic ovarian syndrome OT - Quality of life OT - South Asia OT - Sri Lanka COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Ethics Review Committee of the Faculty of Medicine, University of Colombo (ERC/2025/UCFM/P/2021/575). Institutional permission was obtained from the Directors of De Soysa Hospital for Women and Children and Castle Street Hospital for Women, Colombo. Written informed consent was obtained from all participants prior to enrolment. All methods were carried out in accordance with relevant guidelines and regulations, including the principles of the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/30 05:30 MHDA- 2026/10/30 05:31 CRDT- 2026/10/30 00:54 PHST- 2026/10/30 05:31 [medline] PHST- 2026/10/30 05:30 [pubmed] PHST- 2026/04/21 00:00 [received] PHST- 2026/07/24 00:00 [accepted] PHST- 2026/10/30 00:54 [entrez] AID - 10.1186/s12905-026-04742-2 [pii] AID - 10.1186/s12905-026-04742-2 [doi] PST - epublish SO - BMC Womens Health. 2026 Jul 28;26(1):567. doi: 10.1186/s12905-026-04742-2. PMID- 42958181 OWN - NLM STAT- MEDLINE DCOM- 20261030 LR - 20261030 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Aug 3 TI - Health4Life: a digital intervention to promote healthy diet and movement behaviours from the start of life: protocol for a hybrid effectiveness-implementation study. LID - 3122 [pii] LID - 10.1186/s12889-026-28866-0 [doi] AB - BACKGROUND: Globally and in Sweden childhood overweight and obesity remain major public health issues. The first 1000 days (i.e., conception-24 months) has been identified as the period of greatest developmental plasticity, with the maximum capacity to influence health throughout life. As obesity-related behaviours, including excessive screen time and poor dietary habits, have been found to establish in infancy and continue into early childhood, this demonstrates the need for early life health promotion interventions. Therefore, the aim of this study is to evaluate the effectiveness of and explore the implementation of a digital intervention (Health4Life app) designed to support parents in creating healthy diet and movement behaviours from the start of their infant's life, to promote health and prevent overweight and obesity. METHODS: A two-arm parallel open-label randomized controlled trial, using a hybrid type I implementation-effectiveness design will be conducted. Families will be recruited at the 6-week routine visit at participating child health service (CHS) centers (n = 504). If parents' consent to participate families will be randomized in a 1:1 ratio into the control or intervention group. Both groups receive standard care; however, the intervention group also receives access to the 16-month Health4Life app-based intervention. Primary outcomes are children's dietary intake (questionnaire), physical activity and sleep (accelerometry), and screen time (questionnaire). Secondary outcomes are children's body mass index z-scores (measured at CHS) and parental self-efficacy for promoting health behaviours (questionnaire). The implementation outcomes being explored are acceptability, appropriateness, and feasibility according to CHS nurses (semi-structured interviews) as well as parental satisfaction and usage of the Health4Life app (questionnaires and semi-structured interviews). DISCUSSION: An important mission of CHS is to support parents in establishing healthy diet and movement behaviours, and the Health4Life app is designed to support this by providing early and tailored guidance to families. If shown to be effective as well as acceptable, appropriate and feasible, Health4Life has the potential to be implemented as a complement to CHS nurses' routine work to promote children's health and development in accordance with the Swedish national child health monitoring program. TRIAL REGISTRATION: This trial was registered at Clinicaltrials.gov (ID NCT06798597) on January 29th, 2025. CI - (c) 2026. The Author(s). FAU - Alexandrou, Christina AU - Alexandrou C AD - Department of Medicine Huddinge, Karolinska Institutet, Neo, Huddinge, 141 83, Sweden. FAU - Golsater, Marie AU - Golsater M AD - Department of Nursing, CHILD Research Group, School of Health and Welfare, Jonkoping University, Jonkoping, 551 11, Sweden. AD - The Child Health Services and Futurum - Academy for Health and Care, Region Jonkoping County, Jonkoping, 551 85, Sweden. FAU - Lof, Marie AU - Lof M AD - Department of Medicine Huddinge, Karolinska Institutet, Neo, Huddinge, 141 83, Sweden. AD - Deakin Institute for Physical Activity and Nutrition, Deakin University, Geelong, 3220, Australia. FAU - Hesketh, Kylie D AU - Hesketh KD AD - Deakin Institute for Physical Activity and Nutrition, Deakin University, Geelong, 3220, Australia. FAU - Brown, Vicki AU - Brown V AD - Institute for Health Transformation (IHT), Deakin Health Economics, Deakin University, Geelong, 3220, Australia. FAU - Strid, Anna AU - Strid A AD - Department of Medicine Huddinge, Karolinska Institutet, Neo, Huddinge, 141 83, Sweden. FAU - Gransten, Jennifer AU - Gransten J AD - Department of Medicine Huddinge, Karolinska Institutet, Neo, Huddinge, 141 83, Sweden. FAU - Habel, Henrike AU - Habel H AD - Department of Medicine Huddinge, Karolinska Institutet, Neo, Huddinge, 141 83, Sweden. FAU - Delisle Nystrom, Christine AU - Delisle Nystrom C AUID- ORCID: 0000-0003-3496-8266 AD - Department of Medicine Huddinge, Karolinska Institutet, Neo, Huddinge, 141 83, Sweden. christine.delisle.nystrom@ki.se. AD - Deakin Institute for Physical Activity and Nutrition, Deakin University, Geelong, 3220, Australia. christine.delisle.nystrom@ki.se. LA - eng SI - ClinicalTrials.gov/NCT06798597 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260803 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Health Promotion/methods MH - *Diet, Healthy MH - Infant MH - *Exercise MH - Sweden MH - *Parents/psychology/education MH - *Pediatric Obesity/prevention & control MH - Randomized Controlled Trials as Topic MH - *Mobile Applications MH - Female MH - Child, Preschool MH - Male MH - Health Behavior MH - Digital Health OTO - NOTNLM OT - Child health services OT - Diet OT - Digital health OT - Infancy OT - Physical activity OT - Randomized controlled trial OT - Screen time OT - Sleep OT - mHealth COIS- Declarations. Ethics approval and consent to participate: This study is approved by the Swedish Ethical Review Authority (Dnr: 2024-07372-01; 2025-00542-02; 2025-01222-02) and follows the Declaration of Helsinki. Written informed consent is obtained from both parents. This trial was registered at Clinicaltrials.gov (ID NCT06798597) on January 29th, 2025. Consent for publication: Not applicable. Competing interests: M.L. is the founder and C.D.N. and C.A. are shareholders of the company Science4Families AB. Science4Families AB had no role in this research. The other co-authors have no competing interests to declare. EDAT- 2026/10/30 05:30 MHDA- 2026/10/30 05:31 CRDT- 2026/10/30 00:52 PHST- 2026/10/30 05:31 [medline] PHST- 2026/10/30 05:30 [pubmed] PHST- 2026/04/16 00:00 [received] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/10/30 00:52 [entrez] AID - 10.1186/s12889-026-28866-0 [pii] AID - 10.1186/s12889-026-28866-0 [doi] PST - epublish SO - BMC Public Health. 2026 Aug 3;26(1):3122. doi: 10.1186/s12889-026-28866-0. PMID- 42958121 OWN - NLM STAT- MEDLINE DCOM- 20261030 LR - 20261030 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Aug 1 TI - Distinct associations of APRI and creatinine-based ratios with disease severity and adverse perinatal outcomes in preeclampsia. LID - 1240 [pii] LID - 10.1186/s12884-026-09749-z [doi] AB - OBJECTIVE: To evaluate the discriminatory performance and clinical associations of the aspartate aminotransferase-to-platelet ratio index (APRI), uric acid-to-creatinine (UA/Cr) ratio, and creatinine-to-fibrinogen ratio beyond clinical variables for assessment of disease severity and adverse perinatal outcomes in pregnancies complicated by preeclampsia. METHODS: This retrospective cohort study included 220 singleton pregnancies diagnosed with preeclampsia at a tertiary referral center. Biomarkers were calculated using laboratory parameters obtained at the time of diagnosis and evaluated in relation to disease severity at presentation and adverse perinatal outcomes. A base clinical model including maternal age, body mass index, gestational age at diagnosis, and systolic blood pressure was constructed. Discriminatory performance was assessed using receiver operating characteristic (ROC) curve analysis and changes in the area under the curve (AUC). Multivariable logistic regression analyses were performed for preeclampsia with severe features and adverse neonatal outcomes. RESULTS: Preeclampsia with severe features occurred in 25.5% of patients. The creatinine-to-fibrinogen ratio demonstrated the highest discriminatory performance for distinguishing preeclampsia with severe features from preeclampsia without severe features (AUC = 0.923), followed by UA/Cr (AUC = 0.840) and APRI (AUC = 0.688). The clinical model yielded an AUC of 0.772, which increased to 0.876 with the addition of UA/Cr and to 0.942 with the inclusion of the creatinine-to-fibrinogen ratio, whereas APRI provided minimal additional discriminatory value (AUC = 0.782). In adjusted multivariable analyses, both UA/Cr (OR = 1.75, 95% CI: 1.45-2.11, p < 0.001) and the creatinine-to-fibrinogen ratio (OR = 6.92, 95% CI: 3.55-13.51, p < 0.001) remained independently associated with preeclampsia with severe features. APRI was independently associated with very low birth weight and composite adverse perinatal outcome. CONCLUSION: Creatinine-based composite ratios were significantly associated with the presence of severe features and provided additional discriminatory information beyond clinical variables. Both UA/Cr and the creatinine-to-fibrinogen ratio remained independently associated with maternal disease severity after adjustment for clinical factors, whereas APRI was more closely associated with fetal growth-related adverse outcomes. These laboratory-derived indices may provide complementary information for severity assessment in pregnancies complicated by preeclampsia. CI - (c) 2026. The Author(s). FAU - Yalcin, Serenat Eris AU - Yalcin SE AUID- ORCID: 0000-0002-6465-325X AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Uludag University, Nilufer, Bursa, 16100, Turkey. serenateris@hotmail.com. FAU - Atak, Zeliha AU - Atak Z AD - Department of Obstetrics and Gynecology, Bursa City Hospital, Bursa, Turkey. LA - eng PT - Journal Article DEP - 20260801 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - AYI8EX34EU (Creatinine) RN - EC 2.6.1.1 (Aspartate Aminotransferases) RN - 0 (Biomarkers) RN - 9001-32-5 (Fibrinogen) RN - 268B43MJ25 (Uric Acid) SB - IM MH - Humans MH - Female MH - *Pre-Eclampsia/blood/diagnosis MH - Pregnancy MH - *Creatinine/blood MH - Retrospective Studies MH - *Aspartate Aminotransferases/blood MH - Severity of Illness Index MH - Adult MH - Biomarkers/blood MH - Fibrinogen/analysis/metabolism MH - Uric Acid/blood MH - ROC Curve MH - Platelet Count MH - Pregnancy Outcome MH - Infant, Newborn MH - Logistic Models MH - Gestational Age OTO - NOTNLM OT - APRI OT - Adverse perinatal outcomes OT - Creatinine-fibrinogen ratio OT - Preeclampsia OT - Uric acid-to-creatinine ratio COIS- Declarations. Ethics approval and consent to participate: This retrospective study was approved by the Ethics Review Committee of Bursa City Hospital, who, because of the retrospective, observational nature of our study, and because the data were anonymized, waived the need for informed consent for all included patients. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/30 05:30 MHDA- 2026/10/30 05:31 CRDT- 2026/10/30 00:49 PHST- 2026/10/30 05:31 [medline] PHST- 2026/10/30 05:30 [pubmed] PHST- 2026/04/01 00:00 [received] PHST- 2026/07/28 00:00 [accepted] PHST- 2026/10/30 00:49 [entrez] AID - 10.1186/s12884-026-09749-z [pii] AID - 10.1186/s12884-026-09749-z [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Aug 1;26(1):1240. doi: 10.1186/s12884-026-09749-z. PMID- 42958108 OWN - NLM STAT- MEDLINE DCOM- 20261030 LR - 20261030 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Oct 28 TI - Bouldering-Psychotherapy for treating depression in adolescents (BooSt): study protocol for a randomized controlled trial. LID - 1080 [pii] LID - 10.1186/s12887-026-07935-8 [doi] AB - BACKGROUND: Currently, there are hardly any validated group therapy programs for depressed adolescents in Germany. A recent meta-analysis confirmed a moderate antidepressant effect of exercise in adolescents with depressive symptoms. In addition, four recent systematic reviews reported positive effects of exercise interventions on psychological well-being, mood, and quality of life in adolescents with depression or depressive symptoms. We developed a manualized behavioral-therapy-based group program involving Bouldering-Psychotherapy (BPT) for adolescents (BPT-J) based on the adult version of BPT, which has already demonstrated its efficacy. The aim of the study is to evaluate the efficacy of BPT-J. METHODS: The study is designed as a randomized, controlled, prospective, longitudinal, single-blind trial with two arms (BPT-J intervention group [IG], waitlist-control group [CG]). The primary aim is to investigate the efficacy of the BPT-J group therapy for adolescents for treating depressiveness. Eligible participants are adolescents with subclinical and clinical depressive symptoms between 13 and 18 years of age. The adolescents in the CG are offered participation in an identical intervention after t1. The 10-week intervention is accompanied by four data collection points for all participants: participants and their legal guardians fill out online questionnaires at the start of therapy (t0), immediately after IG therapy (t1), after CG therapy (t2), and 12 months after finalizing the intervention (follow-up, t3). In addition, structured video interviews are conducted at t0 and t1. DISCUSSION: BooSt trial addresses the limited availability of evidence-based group interventions for adolescents with depressive symptoms in routine care. If efficacy is confirmed, BPT-J may represent a scalable, manualized, and potentially well-accepted treatment approach that could complement existing psychotherapeutic services for adolescents. Given the increasing demand and limited access to psychotherapy, the intervention may contribute to improving accessibility of mental health care. The group-based format may additionally support cost-effective implementation, reduce waiting times, facilitate peer support, and help reduce stigmatization associated with mental health treatment. Findings from the BooSt trial may further inform dissemination and implementation strategies in child and adolescent mental health care. TRIAL REGISTRATION: ISRCTN, ISRCTN79659949, prospectively registered 19/02/2025, DOI: https://doi.org/10.1186/ISRCTN79659949 , URL: https://www.isrctn.com/ISRCTN79659949 . CI - (c) 2026. The Author(s). FAU - Luttenberger, Katharina AU - Luttenberger K AUID- ORCID: 0000-0002-9877-5423 AD - Section of Medical Psychology and Medical Sociology, Department of Psychiatry and Psychotherapy, Uniklinikum Erlangen, Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany. AD - Department for Psychosomatic Medicine and Psychotherapy, University for Continuing Education (UWK), Krems, Austria. FAU - Donath, Carolin AU - Donath C AUID- ORCID: 0000-0001-9502-861X AD - Section of Medical Psychology and Medical Sociology, Department of Psychiatry and Psychotherapy, Uniklinikum Erlangen, Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany. FAU - Eversmann, Lola AU - Eversmann L AUID- ORCID: 0009-0007-0913-7352 AD - Section of Medical Psychology and Medical Sociology, Department of Psychiatry and Psychotherapy, Uniklinikum Erlangen, Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany. FAU - Gottlicher, Katharina Louisa AU - Gottlicher KL AUID- ORCID: 0000-0003-0948-7479 AD - Department of Child and Adolescent Mental Health, Uniklinikum Erlangen, Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany. FAU - Scheuermann, Julia-Sophia AU - Scheuermann JS AUID- ORCID: 0000-0001-5764-346X AD - Section of Medical Psychology and Medical Sociology, Department of Psychiatry and Psychotherapy, Uniklinikum Erlangen, Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany. FAU - Brokmeier, Luisa Leonie AU - Brokmeier LL AUID- ORCID: 0000-0003-4136-9704 AD - Section of Medical Psychology and Medical Sociology, Department of Psychiatry and Psychotherapy, Uniklinikum Erlangen, Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany. FAU - Radegast, Anne AU - Radegast A AUID- ORCID: 0009-0002-5521-1887 AD - Department for Psychosomatic Medicine and Psychotherapy, University for Continuing Education (UWK), Krems, Austria. FAU - Scheufele, Pia AU - Scheufele P AUID- ORCID: 0000-0001-8089-2835 AD - Section of Medical Psychology and Medical Sociology, Department of Psychiatry and Psychotherapy, Uniklinikum Erlangen, Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany. pia.scheufele@uk-erlangen.de. FAU - Lewczuk, Piotr AU - Lewczuk P AUID- ORCID: 0000-0002-8101-6535 AD - Department of Psychiatry and Psychotherapy, Uniklinikum Erlangen, Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany. AD - Department of Neurodegeneration Diagnostics, University Hospital Bialystok, Bialystok, Poland. FAU - Kiesel, Vera AU - Kiesel V AUID- ORCID: 0009-0008-7683-135X AD - Section of Medical Psychology and Medical Sociology, Department of Psychiatry and Psychotherapy, Uniklinikum Erlangen, Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany. FAU - Kuntscher, Romi AU - Kuntscher R AD - Section of Medical Psychology and Medical Sociology, Department of Psychiatry and Psychotherapy, Uniklinikum Erlangen, Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany. FAU - Meyer, Sebastian AU - Meyer S AUID- ORCID: 0000-0002-1791-9449 AD - Institute of Medical Informatics, Biometry and Epidemiology (IMBE), Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany. FAU - Hulm, Mark AU - Hulm M AD - Center for Mental Health and Addiction Research, Institut fur Therapieforschung (IFT), Munich, Germany. FAU - Schwarzkopf, Larissa AU - Schwarzkopf L AUID- ORCID: 0000-0002-9402-7700 AD - Center for Mental Health and Addiction Research, Institut fur Therapieforschung (IFT), Munich, Germany. AD - Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Eichler, Anna AU - Eichler A AUID- ORCID: 0000-0001-5584-0961 AD - Department of Child and Adolescent Mental Health, Uniklinikum Erlangen, Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany. FAU - Kratz, Oliver AU - Kratz O AUID- ORCID: 0009-0004-7334-950X AD - Department of Child and Adolescent Mental Health, Uniklinikum Erlangen, Friedrich-Alexander-Universitat Erlangen-Nurnberg (FAU), Erlangen, Germany. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20261028 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Adolescent MH - Single-Blind Method MH - *Depression/therapy MH - Prospective Studies MH - *Psychotherapy, Group/methods MH - Randomized Controlled Trials as Topic MH - Longitudinal Studies MH - Germany MH - Female MH - Male MH - *Behavior Therapy/methods MH - Treatment Outcome OTO - NOTNLM OT - Adolescents OT - Bouldering OT - Bouldering-Psychotherapy OT - Depression OT - Exercise OT - Group therapy OT - Psychotherapy OT - Randomized controlled trial OT - Rock climbing COIS- Declarations. Ethics approval and consent to participate 24: All procedures were approved by the Ethics Committee of the Medical Faculty of the Friedrich-Alexander-Universitat Erlangen-Nurnberg (Ref. 24-484-B).Participation is voluntary, and participants are free to leave the study at any time. All legal matters, such as voluntary participation, right of revocation, and General Data Protection Regulation are considered. The study is conducted with the approval of the responsible ethics committee, in accordance with the national law and the Declaration of Helsinki of 1975 (in the current revised version). Written informed consent to participate is obtained from all participants and their legal guardians. All participants are informed about the study before and during the screening process. This information contains all legal aspects, especially the voluntary participation, right to withdraw without any disadvantages, and data protection (according to the valid relevant data protection regulations) and is available at all time through the project website or on request. A participant information sheet including important information about participation (e.g., intervention, randomization, data protection, data storage) is given to every participant/legal guardian. The opportunity to ask questions will be granted at any time. Participants are given two vouchers for free entries into "their" bouldering gym after completing all data (around 12 euro). No additional financial incentive is given. Consent for publication 32: This manuscript does not contain any individual person's data. Informed consent materials are available from the corresponding author upon request. Competing interests 28: The authors declare no competing interests. EDAT- 2026/10/30 05:30 MHDA- 2026/10/30 05:31 CRDT- 2026/10/30 00:48 PHST- 2026/10/30 05:31 [medline] PHST- 2026/10/30 05:30 [pubmed] PHST- 2026/05/26 00:00 [received] PHST- 2026/10/21 00:00 [accepted] PHST- 2026/10/30 00:48 [entrez] AID - 10.1186/s12887-026-07935-8 [pii] AID - 10.1186/s12887-026-07935-8 [doi] PST - epublish SO - BMC Pediatr. 2026 Oct 28;26(1):1080. doi: 10.1186/s12887-026-07935-8. PMID- 42956813 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261029 LR - 20261029 IS - 2287-9129 (Electronic) IS - 2287-9110 (Linking) VI - 32 IP - 4 DP - 2026 Oct TI - Predictive value of birth weight and age for preliminary community-level stratification of undernutrition risk among children under 5: a cross-sectional study in rural Indonesia. PG - 464-479 LID - 10.4094/chnr.2026.022 [doi] AB - PURPOSE: We evaluated the predictive value of low birth weight (LBW), child age, and maternal education for stunting, wasting, and underweight among children aged 0-59 months. METHODS: We analyzed cross-sectional surveillance data from 394 children in Pesisir Selatan District, West Sumatra, Indonesia, and classified nutritional status according to the 2006 World Health Organization Child Growth Standards. For each outcome, we fitted a parsimonious logistic model (LBW, age, maternal education, and sex) and an expanded model incorporating 8 additional variables (9 regression coefficients). We assessed discrimination using the area under the receiver operating characteristic curve (AUROC) and calibration using the Hosmer-Lemeshow test and calibration slope. RESULTS: The prevalence of stunting, wasting, and underweight was 14.5%, 10.7%, and 17.3%, respectively. LBW was the strongest predictor in the parsimonious model for stunting (adjusted odds ratio [AOR], 4.85; 95% confidence interval [CI], 2.53-9.29), wasting (AOR, 2.88; 95% CI, 1.38-6.02), and underweight (AOR, 4.34; 95% CI, 2.30-8.19; p.05) and increased optimism. CONCLUSION: The parsimonious model showed modest discrimination for stunting and underweight. Discrimination for wasting was inadequate. A predictive contribution from the added variables could not be demonstrated with the available number of events. These preliminary findings require external validation before community-level application. FAU - Maidelwita, Yani AU - Maidelwita Y AD - Lecturer, Faculty of Health and Science, Universitas Mercubaktijaya, Padang City, Indonesia. yanimaidelwita@mercubaktijaya.ac.id. FAU - Rahmayanti, Rini AU - Rahmayanti R AD - Lecturer, Faculty of Health and Science, Universitas Mercubaktijaya, Padang City, Indonesia. FAU - Suciana, Sri AU - Suciana S AD - Lecturer, Faculty of Health and Science, Universitas Mercubaktijaya, Padang City, Indonesia. FAU - Sarfika, Rika AU - Sarfika R AD - Lecturer, Department of Mental Health and Community, Faculty of Nursing, Universitas Andalas, Padang City, Indonesia. FAU - Bin Sansuwito, Tukimin AU - Bin Sansuwito T AD - Lecturer, School of Nursing, Lincoln University College, Petaling Jaya, Malaysia. LA - eng PT - Journal Article DEP - 20261031 PL - Korea (South) TA - Child Health Nurs Res JT - Child health nursing research JID - 101603835 OTO - NOTNLM OT - Birth weight OT - Child nutrition disorders OT - Community health services OT - Indonesia OT - Risk assessment EDAT- 2026/10/29 23:28 MHDA- 2026/10/29 23:29 CRDT- 2026/10/29 19:53 PHST- 2025/04/06 00:00 [received] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/10/29 23:29 [medline] PHST- 2026/10/29 23:28 [pubmed] PHST- 2026/10/29 19:53 [entrez] AID - chnr.2026.022 [pii] AID - 10.4094/chnr.2026.022 [doi] PST - ppublish SO - Child Health Nurs Res. 2026 Oct;32(4):464-479. doi: 10.4094/chnr.2026.022. Epub 2026 Oct 31. PMID- 42956672 OWN - NLM STAT- Publisher LR - 20261029 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 229 DP - 2026 Oct 29 TI - Australian infants' food avoidance trajectory groups across the first year of life and associations with food fussiness and vegetable intake at 12 months. PG - 108804 LID - S0195-6663(26)00366-1 [pii] LID - 10.1016/j.appet.2026.108804 [doi] AB - Food avoidant eating behaviours in children are negatively associated with vegetable intake and diet quality. However, little is known about trajectories of food avoidance during infancy. This study examined food avoidant trajectory groups in the first year of life and their associations with fussiness and vegetable intake. Australian parents of infants aged /=7.0 mmol/L or HbA1c >/=6.5%. RCS analyses indicated that TyG, TyG-ABSI, and TyG-WWI were approximately linearly associated with prediabetes or diabetes, whereas TyG-BMI, TyG-WC, and TyG-WHtR showed nonlinear relationships. ROC analyses demonstrated comparable discriminatory performance across all indicators ( approximately 0.77). CONCLUSION: The TyG index and its derived indicators correlate positively with the prediabetes/diabetes in children. However, no superior diagnostic potential was observed for TyG obesity composite indicators compared to the standalone TyG index. CI - Copyright (c) 2026 National Medical Association. Published by Elsevier Inc. All rights reserved. FAU - Wang, Jing AU - Wang J AD - Department of Paediatrics, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, 271000, China. FAU - Wei, Congcong AU - Wei C AD - Department of Paediatrics, The Second Affiliated Hospital of Shandong First Medical University, Tai'an, 271000, China. Electronic address: tutunuannuan6688@163.com. LA - eng PT - Journal Article DEP - 20261029 PL - United States TA - J Natl Med Assoc JT - Journal of the National Medical Association JID - 7503090 SB - IM OTO - NOTNLM OT - American adolescents OT - Metabolic syndrome OT - Obesity-related indicators OT - Prediabetes OT - Triglyceride-glucose index EDAT- 2026/10/29 23:28 MHDA- 2026/10/29 23:28 CRDT- 2026/10/29 19:00 PHST- 2026/05/29 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/29 23:28 [medline] PHST- 2026/10/29 23:28 [pubmed] PHST- 2026/10/29 19:00 [entrez] AID - S0027-9684(26)00181-1 [pii] AID - 10.1016/j.jnma.2026.101112 [doi] PST - aheadofprint SO - J Natl Med Assoc. 2026 Oct 29;118(6):101112. doi: 10.1016/j.jnma.2026.101112. PMID- 42956272 OWN - NLM STAT- MEDLINE DCOM- 20261029 LR - 20261029 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Oct 29 TI - Improving Materials for a Technology-Based Childhood Obesity Intervention for Hispanic/Latino Families in Rural Nebraska: Mixed Methods Usability Test. PG - e84388 LID - 10.2196/84388 [doi] AB - BACKGROUND: Childhood obesity remains a public health concern in the United States, disproportionately affecting Hispanic/Latino and rural populations. Despite this disparity, there is a lack of culturally relevant programs specifically designed to reach this population. To address this gap, our team culturally adapted a technology-based childhood obesity intervention, Hispanic Family Connections (HFC), targeting Hispanic/Latino families living in rural areas. The intervention comprises 2 main components: interactive voice response (IVR) calls and a workbook with at-home activities to promote family engagement. OBJECTIVE: The objectives were to (1) evaluate the usability of the IVR calls and workbook included in the HFC intervention and (2) document and plan adaptations to these components using the FRAME (Framework for Reporting Adaptations and Modifications-Enhanced). METHODS: We conducted 5 mixed methods, task-based usability tests (UTs) using the think-aloud procedure. All 5 participants were women, self-identified as Hispanic/Latino, and were Spanish literate. Each participant completed 3 think-aloud tasks designed to evaluate the usability of the IVR calls and workbook chapters. Usability was assessed using the After-Scenario Questionnaire (ASQ) at the end of each task and the System Usability Scale (SUS) at the end of the UT session. All sessions were recorded, and data were organized into two primary categories: (1) quantitative results (ASQ and SUS) and (2) qualitative data (participants' comments and researchers' observations). Findings were compiled and analyzed following the 8 main domains of FRAME. RESULTS: For the workbook, ASQ scores showed a high level of ease in task completion (mean 1.1, SD 0.32), satisfaction with completion time (mean 1.0, SD 0.00), and satisfaction with support information (mean 1.5, SD 0.97). For the IVR calls, participants reported a higher level of ease in task completion (mean 1.0, SD 0.00), satisfaction with completion time (mean 1.0, SD 0.00), and satisfaction with support information (mean 1.2, SD 0.45). SUS results were positive for 80% (4/5) of participants, with an average usability score above the benchmark (mean 75.5, SD 15.04). Using FRAME, we identified and documented 30 suggestions for adaptations and improvements to the workbook and IVR calls. The majority of suggestions were content-related (n=26, 86.67%), with most focusing on tailoring/tweaking, or refining existing materials. CONCLUSIONS: The UT results, combined with systematic documentation using FRAME, allowed us to identify and prioritize the adaptations needed to improve the intervention materials. These refinements will prepare the HFC intervention for implementation in a subsequent feasibility study. CI - (c) Thais F Alves, Natalia Santos, Camila Fabiana Rossi Squarcini, Tzeyu L Michaud, Elisa Brosina De Leon, Fabio Almeida, Fabiana Brito. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Alves, Thais F AU - Alves TF AUID- ORCID: 0000-0003-3246-8014 AD - Department of Health Services Research and Administration, College of Public Health, University of Nebraska Medical Center, 42nd and Emile, Omaha, NE, 68198-4350, United States, 1 402-559-2902. FAU - Santos, Natalia AU - Santos N AUID- ORCID: 0000-0001-7833-3671 AD - Department of Health Promotion, College of Public Health, University of Nebraska Medical Center, Omaha, NE, United States. FAU - Rossi Squarcini, Camila Fabiana AU - Rossi Squarcini CF AUID- ORCID: 0000-0002-1605-4834 AD - Department of Health Sciences, Universidade Estadual de Santa Cruz, Ilheus, Brazil. FAU - Michaud, Tzeyu L AU - Michaud TL AUID- ORCID: 0000-0002-2053-3942 AD - Department of Health Promotion, College of Public Health, University of Nebraska Medical Center, Omaha, NE, United States. FAU - De Leon, Elisa Brosina AU - De Leon EB AUID- ORCID: 0000-0002-2559-6897 AD - Universidade Federal de Amazonas, Manaus, Brazil. FAU - Almeida, Fabio AU - Almeida F AUID- ORCID: 0000-0002-2404-0694 AD - Department of Physical Education, Universidade Federal de Santa Catarina, Florianopolis, Brazil. FAU - Brito, Fabiana AU - Brito F AUID- ORCID: 0000-0002-1262-4246 AD - Department of Physical Education, Universidade Federal de Santa Catarina, Florianopolis, Brazil. LA - eng PT - Journal Article DEP - 20261029 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - *Hispanic or Latino/statistics & numerical data/psychology MH - Female MH - Nebraska MH - Rural Population/statistics & numerical data MH - *Pediatric Obesity/therapy/ethnology/prevention & control/psychology MH - Child MH - Adult OTO - NOTNLM OT - FRAME OT - Framework for Reporting Adaptations and Modifications-Enhanced OT - Hispanics OT - childhood obesity OT - rural communities OT - usability testing OT - user-centered design EDAT- 2026/10/29 17:36 MHDA- 2026/10/29 17:37 CRDT- 2026/10/29 15:13 PHST- 2025/09/18 00:00 [received] PHST- 2026/08/15 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/10/29 17:37 [medline] PHST- 2026/10/29 17:36 [pubmed] PHST- 2026/10/29 15:13 [entrez] AID - v10i1e84388 [pii] AID - 10.2196/84388 [doi] PST - epublish SO - JMIR Form Res. 2026 Oct 29;10:e84388. doi: 10.2196/84388. PMID- 42956166 OWN - NLM STAT- MEDLINE DCOM- 20261029 LR - 20261029 IS - 2057-4347 (Electronic) IS - 2057-4347 (Linking) VI - 12 IP - 5 DP - 2026 Oct TI - Masticatory Muscle Characteristics as a Biological Explanation for Interindividual Variability During Class II Functional Appliance Treatment: A Conceptual Synthesis. LID - e70496 [pii] LID - 10.1002/cre2.70496 [doi] AB - OBJECTIVES: To conceptually synthesize existing evidence on whether masticatory muscle characteristics, assessed by masseter muscle thickness, may explain interindividual variability in skeletal and dentoalveolar treatment outcomes following functional appliance therapy in children with Class II malocclusion. Additionally, to explore the potential of the mandibular gonial angle as a practical cephalometric indicator for predicting treatment response. MATERIAL AND METHODS: Previously published studies investigating the effects of functional appliances on skeletal and dentoalveolar outcomes in children with Class II malocclusion were conceptually synthesized. Particular attention was given to the relationship between baseline masseter muscle thickness, mandibular gonial angle, and treatment-related skeletal and dentoalveolar adaptations. RESULTS: The available evidence suggests that baseline masticatory muscle characteristics may influence treatment outcomes. Children with reduced masseter muscle thickness tend to exhibit greater dentoalveolar adaptations, including increased mandibular incisor proclination and distal displacement of the maxillary dentition. As the gonial region represents the attachment site of the masseter and medial pterygoid muscles, variations in muscle size and functional loading may influence gonial morphology. A more obtuse gonial angle appears to be associated with greater dentoalveolar compensation during functional appliance therapy, characterized by increased mandibular incisor proclination and maxillary incisor retroclination. CONCLUSIONS: Masticatory muscle characteristics may contribute to interindividual variability in treatment response to functional appliances in children with Class II malocclusion. The mandibular gonial angle may serve as a practical surrogate cephalometric marker for identifying patients who are more likely to exhibit predominantly dentoalveolar rather than skeletal adaptations. However, further clinical studies are required to validate its predictive value and clarify the relationship between masticatory muscle characteristics and treatment outcomes. CI - (c) 2026 The Author(s). Clinical and Experimental Dental Research published by John Wiley & Sons Ltd. FAU - Kiliaridis, Stavros AU - Kiliaridis S AUID- ORCID: 0000-0001-9548-2628 AD - Division of Orthodontics, Faculty of Medicine, University Clinics of Dental Medicine (CUMD), University of Geneva, Geneva, Switzerland. AD - Department of Orthodontics and Dentofacial Orthopedics, Dental School/Medical Faculty, University of Bern, Bern, Switzerland. FAU - Antonarakis, Gregory S AU - Antonarakis GS AUID- ORCID: 0000-0001-6741-6922 AD - Division of Orthodontics, Faculty of Medicine, University Clinics of Dental Medicine (CUMD), University of Geneva, Geneva, Switzerland. LA - eng PT - Journal Article PT - Review PL - United States TA - Clin Exp Dent Res JT - Clinical and experimental dental research JID - 101692332 SB - IM MH - Humans MH - *Malocclusion, Angle Class II/therapy/physiopathology MH - *Orthodontic Appliances, Functional MH - Cephalometry MH - *Masseter Muscle/physiology/diagnostic imaging/anatomy & histology MH - *Masticatory Muscles/physiology MH - Child MH - Mandible MH - Treatment Outcome MH - Adaptation, Physiological PMC - PMC13719048 OTO - NOTNLM OT - Class II malocclusion OT - dentoalveolar adaptation OT - gonial angle OT - masseter muscle OT - ultrasonography COIS- The authors declare no conflicts of interest. EDAT- 2026/10/29 17:36 MHDA- 2026/10/29 17:37 PMCR- 2026/10/29 CRDT- 2026/10/29 14:15 PHST- 2026/09/12 00:00 [revised] PHST- 2026/07/17 00:00 [received] PHST- 2026/10/17 00:00 [accepted] PHST- 2026/10/29 17:37 [medline] PHST- 2026/10/29 17:36 [pubmed] PHST- 2026/10/29 14:15 [entrez] PHST- 2026/10/29 00:00 [pmc-release] AID - e70496 [pii] AID - CRE270496 [pii] AID - 10.1002/cre2.70496 [doi] PST - ppublish SO - Clin Exp Dent Res. 2026 Oct;12(5):e70496. doi: 10.1002/cre2.70496. PMID- 42955865 OWN - NLM STAT- Publisher LR - 20261029 IS - 1753-4887 (Electronic) IS - 0029-6643 (Linking) DP - 2026 Oct 29 TI - Menu Evaluation Tools in Food Services: An Integrative Review. LID - nuag158 [pii] LID - 10.1093/nutrit/nuag158 [doi] AB - CONTEXT: The growing demand for meals outside the home has boosted the food service sector, but there are constant concerns regarding the nutritional quality of the meals offered. In this scenario, menus play a strategic role in promoting health and in defining population dietary patterns. OBJECTIVE: This integrative review aimed to identify the instruments used to evaluate menus in food service settings across different contexts and target audiences. DATA SOURCES: This is an integrative review with a systematic search in the LILACS, Scopus, PubMed, and Web of Science databases, with controlled and uncontrolled descriptors. Original studies published between 2003 and 2025 that described the development of menu evaluation instruments aimed at healthy food service were included. DATA EXTRACTION: Data were extracted on the characteristics of the instruments, including target population, food service setting, scope, evaluation approach, assessment perspectives, number of items, country of development, and validation status. DATA ANALYSIS: Data were summarized using descriptive statistics, including absolute and relative frequencies. A total of 29 studies were included, with a predominance of instruments aimed at children's menus (55.2%) and with a qualitative approach (72.4%). Brazil had the largest number of developed instruments, followed by Spain, the United States, and Portugal. Only 58.6% of the instruments presented some type of validation. The instruments varied in scope (menu or menu + context), evaluation method (qualitative, quantitative, or qualitative-quantitative), and the number of perspectives covered, with 10.3% multidimensional (ie, having 4 or more dimensions). CONCLUSION: The review showed advances in evaluating menus for the child population and in incorporating sustainability as an analytical parameter. However, gaps remain in validation and the development of multidimensional instruments, underscoring the need for validated and adapted tools to promote healthier, more sustainable menus. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the International Life Sciences Institute. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Lima, Livia Bacharini AU - Lima LB AUID- ORCID: 0000-0003-0746-3414 AD - Department of Nutrition, University of Brasilia, Brasilia, DF, 70910-900, Brazil. FAU - Dos Santos, Emanuele Batistela AU - Dos Santos EB AD - Department of Nutrition, Federal University of Mato Grosso, Cuiaba, MT, 78070-900, Brazil. FAU - Botelho, Raquel Braz Assuncao AU - Botelho RBA AUID- ORCID: 0000-0002-0369-287X AD - Department of Nutrition, University of Brasilia, Brasilia, DF, 70910-900, Brazil. FAU - Akutsu, Rita de Cassia AU - Akutsu RC AD - Department of Nutrition, University of Brasilia, Brasilia, DF, 70910-900, Brazil. LA - eng GR - 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil (CAPES)/ PT - Journal Article DEP - 20261029 PL - United States TA - Nutr Rev JT - Nutrition reviews JID - 0376405 SB - IM OTO - NOTNLM OT - food service systems OT - integrative review OT - menu assessment OT - nutrition science OT - validated tool EDAT- 2026/10/29 17:36 MHDA- 2026/10/29 17:36 CRDT- 2026/10/29 13:13 PHST- 2026/10/29 17:36 [medline] PHST- 2026/10/29 17:36 [pubmed] PHST- 2026/10/29 13:13 [entrez] AID - 9004678 [pii] AID - 10.1093/nutrit/nuag158 [doi] PST - aheadofprint SO - Nutr Rev. 2026 Oct 29:nuag158. doi: 10.1093/nutrit/nuag158. PMID- 42955709 OWN - NLM STAT- Publisher LR - 20261029 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 Oct 29 TI - Whether substituting high-fat dairy with low-fat dairy changes the risk of attention-deficit hyperactivity disorder: A case-control study. PG - 2601060261501614 LID - 10.1177/02601060261501614 [doi] AB - BackgroundAttention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in children, with potential influences from modifiable dietary factors. Evidence on the differential effects of low-fat and high-fat dairy on ADHD risk is limited.AimTo examine associations between total, low-fat, and high-fat dairy intake and ADHD risk, and to assess the impact of substituting high-fat dairy with low-fat dairy in children.MethodsA case-control study was conducted on 150 Iranian children aged 4-12 years, including 62 with ADHD and 88 controls. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. Logistic regression was used to examine the association between dairy intake and ADHD risk, adjusting for energy intake, body mass index, age, sex, and socioeconomic status. Substitution analysis evaluated the effect of replacing 1 g/day of high-fat dairy with low-fat dairy.SummaryChildren with ADHD consumed significantly less total and low-fat dairy than controls, whereas high-fat dairy intake did not differ significantly between groups. Higher total and low-fat dairy intakes were inversely associated with ADHD risk (odds ratio (OR) = 0.974 and 0.970, respectively; both P < 0.001). High-fat dairy intake was not significantly associated with ADHD risk after full adjustment. Substituting 1 g/day of high-fat dairy with low-fat dairy was associated with lower odds of ADHD (OR = 0.981; P = 0.029). These findings suggest that greater consumption of total and low-fat dairy, as well as replacing high-fat with low-fat dairy, may be associated with lower ADHD risk in children. FAU - Keyhanpour, Shayesteh AU - Keyhanpour S AUID- ORCID: 0009-0006-6939-7941 AD - Student Research Committee, Nutrition and Food Security Research Center and Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. RINGGOLD: 48455 FAU - Shams, Fatemeh AU - Shams F AD - Student Research Committee, Nutrition and Food Security Research Center and Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. RINGGOLD: 48455 FAU - Najarian, Maryam AU - Najarian M AD - Student Research Committee, Nutrition and Food Security Research Center and Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. RINGGOLD: 48455 FAU - Abbasi, Khadijeh AU - Abbasi K AD - Department of Community Nutrition, Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. RINGGOLD: 48455 FAU - Ghiasvand, Reza AU - Ghiasvand R AD - Department of Community Nutrition, Food Security Research Center, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. RINGGOLD: 48455 FAU - Rouhani, Mohammad Hossein AU - Rouhani MH AUID- ORCID: 0000-0003-2451-0083 AD - Nutrition and Food Security Research Center, Department of Clinical Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran. RINGGOLD: 600752 LA - eng PT - Journal Article DEP - 20261029 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - Dairy intake OT - attention-deficit hyperactivity disorder OT - case-control study OT - children EDAT- 2026/10/29 17:36 MHDA- 2026/10/29 17:36 CRDT- 2026/10/29 12:34 PHST- 2026/10/29 17:36 [medline] PHST- 2026/10/29 17:36 [pubmed] PHST- 2026/10/29 12:34 [entrez] AID - 10.1177/02601060261501614 [doi] PST - aheadofprint SO - Nutr Health. 2026 Oct 29:2601060261501614. doi: 10.1177/02601060261501614. PMID- 42955525 OWN - NLM STAT- Publisher LR - 20261029 IS - 1573-6628 (Electronic) IS - 1092-7875 (Linking) DP - 2026 Oct 28 TI - Cross-Cultural Factorial Validation of the Children's Eating Behavior Questionnaire (CEBQ) in Samoan Children: A Methodological Note. LID - 10.1007/s10995-026-04324-6 [doi] AB - OBJECTIVES: To evaluate the factorial validity of the 35-item Children's Eating Behavior Questionnaire (CEBQ) among Samoan children and assess whether empirically derived subscales were associated with weight status. METHODS: Caregivers of n = 400 children aged 5-11 years in the ongoing Ola Tuputupua'e cohort study completed the CEBQ. We tested the original eight-factor structure using confirmatory factor analysis. Because model fit was poor, we conducted exploratory factor analysis and used multinomial logistic regression to examine associations between derived subscales and child weight status. RESULTS: The original CEBQ structure fit poorly (chi-square/df = 3.53, CFI = 0.654, TLI = 0.613, RMSEA = 0.080). EFA identified a 14-item, three-factor solution: Enjoyment of Food, Emotional Undereating, and Emotional Overeating. Compared with children in the lowest Enjoyment of Food tertile, those in the second and third tertiles had higher adjusted odds of obesity (aOR = 4.59, 95% CI: 2.56-8.23; aOR = 10.56, 95% CI: 4.79-23.26, respectively). Emotional eating factors were not significantly associated with weight status. CONCLUSION: The original CEBQ factor structure was not replicated among Samoan children. The alternative three-factor structure requires confirmation, but the findings underscore the need to establish measurement validity before applying eating behavior instruments across cultural settings. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Tian, Wenya AU - Tian W AD - IQVIA RDS Inc., Durham, NC, USA. AD - Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA. FAU - Choy, Courtney C AU - Choy CC AD - Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA. AD - Department of Nutrition and Integrative Physiology, Center for Metabolic Health, University of Utah, Salt Lake City, UT, USA. FAU - Manuele, Analosa AU - Manuele A AD - Ministry of Health, Ififi Street, Motootua, Apia, Samoa. FAU - Reupena, Muagututia S AU - Reupena MS AD - Lutia i Puava ae Mapu i Fagalele, Apia, Samoa. FAU - Duckham, Rachel L AU - Duckham RL AD - Institute for Physical Activity and Nutrition (IPAN), Deakin University, 221 Burwood Highway, Burwood, VIC, 3125, Australia. AD - Australian Institute for Musculoskeletal Science, Western Centre for Health Research and Education, Sunshine Hospital, 176 Furlong Road, St. Albans, VIC, 3021, Australia. FAU - Naseri, Take AU - Naseri T AD - Ministry of Health, Ififi Street, Motootua, Apia, Samoa. FAU - Hawley, Nicola L AU - Hawley NL AUID- ORCID: 0000-0002-2601-3454 AD - Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA. nicola.hawley@yale.edu. FAU - Soti-Ulberg, Christina AU - Soti-Ulberg C AD - Ministry of Health, Ififi Street, Motootua, Apia, Samoa. LA - eng GR - 1F31Hl147414/HL/NHLBI NIH HHS/United States GR - R00HL166781/HL/NHLBI NIH HHS/United States GR - D43TW010540/TW/FIC NIH HHS/United States PT - Journal Article DEP - 20261028 PL - United States TA - Matern Child Health J JT - Maternal and child health journal JID - 9715672 SB - IM OTO - NOTNLM OT - CEBQ OT - Child eating behavior OT - Confirmatory factor analysis OT - Obesity COIS- Declarations. Conflict of interest: The authors have no conflicts of interest to declare. Ethical Approval: The Yale University Institutional Review Board (IRB Number 2000020519) and the Health Research Committee at the Samoa Ministry of Health approved all study procedures. Consent to Participate: Primary caregivers provided written informed consent for their child's participation in the study. Children under the age of seven provided their verbal assent; children seven years and older provided written assent. Consent for Publication: No individual level data is presented in this manuscript. EDAT- 2026/10/29 17:36 MHDA- 2026/10/29 17:36 CRDT- 2026/10/29 12:29 PHST- 2025/04/20 00:00 [received] PHST- 2026/09/04 00:00 [accepted] PHST- 2026/10/29 17:36 [medline] PHST- 2026/10/29 17:36 [pubmed] PHST- 2026/10/29 12:29 [entrez] AID - 10.1007/s10995-026-04324-6 [pii] AID - 10.1007/s10995-026-04324-6 [doi] PST - aheadofprint SO - Matern Child Health J. 2026 Oct 28. doi: 10.1007/s10995-026-04324-6. PMID- 42954248 OWN - NLM STAT- Publisher LR - 20261029 IS - 1751-8431 (Electronic) IS - 1751-8423 (Linking) DP - 2026 Oct 29 TI - Upper-limb accelerometry in children with cerebral palsy: a scoping review. PG - 1-11 LID - 10.1080/17518423.2026.2747713 [doi] AB - PURPOSE: Among children with cerebral palsy (CP), gains on standardized upper-limb (UL) capacity measures do not necessarily translate into greater spontaneous arm use in everyday environments. This scoping review mapped how UL accelerometry - predominantly bilateral wrist-worn accelerometry - is used in children and adolescents with CP to examine (i) construct validity against standardized UL measures and (ii) intervention monitoring in treatment settings and everyday environments. METHODS: Following Joanna Briggs Institute methodology and PRISMA-ScR guidance, PubMed, Embase, and CINAHL were searched for English-language studies published between January 2000 and May 16, 2026. Peer-reviewed studies were included if they involved children and adolescents (0-18 years) with CP that used UL-worn accelerometers to report quantitative metrics in standardized or free-living settings. RESULTS: Nineteen studies met the inclusion criteria. In construct-validity studies, asymmetry-focused metrics showed the most consistent associations with standardized bimanual measures and manual ability classifications, with the strongest relationships observed in standardized sessions and weaker, context-dependent associations in free-living monitoring. In intervention studies, accelerometry was consistently sensitive to within-session dose and immediate behavioral change during intervention sessions. However, translation to spontaneous everyday arm use was heterogeneous, with several studies showing improved clinical scores without parallel gains in free-living accelerometry metrics. CONCLUSION: UL accelerometry provides objective performance information to complement assessment and neurorehabilitation monitoring in children with CP, especially when asymmetry-oriented metrics are matched to the clinical question and recording context. Its clearest current role is as a complement to standardized assessment and as a tool to quantify in-session engagement, whereas evidence for sustained transfer to everyday arm use remains inconsistent. Future studies should consistently report device model and placement, wear protocol, valid wear time, preprocessing methods, and metric definitions. FAU - Youngsub, Hwang AU - Youngsub H AUID- ORCID: 0000-0001-8981-3486 AD - Medical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Republic of Korea. FAU - Choe, Yumi AU - Choe Y AUID- ORCID: 0009-0006-2059-125X AD - Research Institute for Future Medicine, Samsung Medical Center, Seoul, Republic of Korea. FAU - Kwon, Jeong-Yi AU - Kwon JY AUID- ORCID: 0000-0003-2011-8834 AD - Department of Physical and Rehabilitation Medicine, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, Republic of Korea. LA - eng PT - Journal Article PT - Review DEP - 20261029 PL - England TA - Dev Neurorehabil JT - Developmental neurorehabilitation JID - 101304394 SB - IM OTO - NOTNLM OT - Accelerometry OT - bimanual asymmetry OT - cerebral palsy OT - upper limb OT - wearable sensors EDAT- 2026/10/29 15:20 MHDA- 2026/10/29 15:20 CRDT- 2026/10/29 07:03 PHST- 2026/10/29 15:20 [medline] PHST- 2026/10/29 15:20 [pubmed] PHST- 2026/10/29 07:03 [entrez] AID - 10.1080/17518423.2026.2747713 [doi] PST - aheadofprint SO - Dev Neurorehabil. 2026 Oct 29:1-11. doi: 10.1080/17518423.2026.2747713. PMID- 42954148 OWN - NLM STAT- MEDLINE DCOM- 20261029 LR - 20261029 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Oct 28 TI - A Mobile Health Intervention to Reduce Sedentary Behavior Among Adolescents and Early Young Adults Receiving Treatment for Acute Lymphoblastic Leukemia: Protocol for a Single-Arm Feasibility Trial. PG - e107278 LID - 10.2196/107278 [doi] AB - BACKGROUND: Sedentary behavior (SB) is highly prevalent among adolescent and early young adult (eAYA) patients with acute lymphoblastic leukemia (ALL) during treatment and contributes to cardiometabolic complications and morbidity among long-term survivors. SB is distinct from physical inactivity and independently associated with adverse health outcomes, yet few interventions in pediatric oncology have directly targeted reducing SB. OBJECTIVE: The RESET in ALL trial was designed as a two-part study to address this research gap. This protocol describes part 1 (1A and 1B, feasibility trial and optimization phase, respectively), including trial design, analysis plan, and anticipated approach to intervention refinement. METHODS: Part 1A was a 12-week, single-arm feasibility trial evaluating a multicomponent mobile health intervention to reduce SB among 20 eAYA patients (ages 12-21 y) with ALL receiving maintenance therapy at Children's Hospital Los Angeles. The intervention included a Fitbit tracker with inactivity-triggered prompts, 3 individualized coaching sessions, and a novel app-based peer support group. Primary outcomes were feasibility (retention, enrollment, and tracker wear time) and acceptability (exit surveys and interviews). Secondary outcomes were accelerometer-measured sedentary time and self-reported sitting time. Exploratory outcomes were cardiometabolic biomarkers, anthropometrics, health-related quality of life, and psychosocial and environmental correlates of SB. Part 1B was a synthetic step in which participant feedback and outcome data from part 1A guided optimization of the intervention prior to being tested via a randomized controlled trial in the future part 2 trial. RESULTS: The study received initial funding in June 2024 and additional funding in July 2025. Participant enrollment and data collection began in September 2024 and were completed in December 2025. Participant enrollment, data collection, and data analysis have been completed. The manuscript reporting the primary trial outcomes is currently under peer review. CONCLUSIONS: This protocol describes the first multicomponent mobile health intervention to reduce SB metrics in eAYAs undergoing cancer treatment. Part 1 (1A and 1B) of the RESET in ALL trial provides the foundation for the development and feasibility evaluation of a novel on-therapy SB intervention, integrating wearable technology, individualized coaching, and peer support. Using a sequential design, in which prior trials inform the optimization of subsequent trials, we aim to develop and refine a scalable, clinically integrated approach to behavior change during treatment that enhances health outcomes in eAYA populations. CI - (c) Brittany J Ivory, Yueh-Yun Chi, Britni R Belcher, David R Freyer. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Ivory, Brittany J AU - Ivory BJ AUID- ORCID: 0000-0003-2722-5632 AD - Cancer and Blood Disease Institute, Children's Hospital of Los Angeles, 4650 Sunset Blvd, MS #54, Los Angeles, CA, 90027, United States, 1 323-361-3097. AD - Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. FAU - Chi, Yueh-Yun AU - Chi YY AUID- ORCID: 0000-0002-9197-5684 AD - Cancer and Blood Disease Institute, Children's Hospital of Los Angeles, 4650 Sunset Blvd, MS #54, Los Angeles, CA, 90027, United States, 1 323-361-3097. AD - Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. AD - Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. FAU - Belcher, Britni R AU - Belcher BR AUID- ORCID: 0000-0001-7965-7520 AD - Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. FAU - Freyer, David R AU - Freyer DR AUID- ORCID: 0000-0001-5280-990X AD - Cancer and Blood Disease Institute, Children's Hospital of Los Angeles, 4650 Sunset Blvd, MS #54, Los Angeles, CA, 90027, United States, 1 323-361-3097. AD - Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. AD - Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. AD - Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20261028 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Adolescent MH - Feasibility Studies MH - *Precursor Cell Lymphoblastic Leukemia-Lymphoma/therapy/psychology MH - *Sedentary Behavior MH - Young Adult MH - Male MH - Female MH - Child OTO - NOTNLM OT - ALL OT - AYA OT - acute lymphoblastic leukemia OT - adolescent and young adult cancer OT - childhood cancer OT - feasibility study OT - mobile health OT - physical activity OT - sedentary behavior OT - sedentary time EDAT- 2026/10/29 15:20 MHDA- 2026/10/29 15:21 CRDT- 2026/10/29 06:36 PHST- 2026/07/18 00:00 [received] PHST- 2026/08/26 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/29 15:21 [medline] PHST- 2026/10/29 15:20 [pubmed] PHST- 2026/10/29 06:36 [entrez] AID - v15i1e107278 [pii] AID - 10.2196/107278 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Oct 28;15:e107278. doi: 10.2196/107278. PMID- 42953973 OWN - NLM STAT- MEDLINE DCOM- 20261029 LR - 20261029 IS - 1476-4954 (Electronic) IS - 1476-4954 (Linking) VI - 39 IP - 1 DP - 2026 Dec TI - Analysis of the distribution characteristics of serum phosphorus levels in neonates in the early neonatal period based on gestational age stratification and their association with perinatal factors. PG - 2746880 LID - 10.1080/14767058.2026.2746880 [doi] AB - OBJECTIVE: To describe the distribution of serum phosphorus, 25-hydroxyvitamin D (25-OHD), and alkaline phosphatase (ALP) levels in neonates of different gestational ages in the early neonatal period, analyze the association between perinatal factors and serum phosphorus, and explore whether there is a non-linear relationship between gestational age and serum phosphorus. METHODS: A prospective cohort design was used to include 360 singleton neonates born in our hospital and transferred to the neonatal department between August 2019 and June 2022, with gestational ages ranging from 27(+0) to 41(+6 )weeks. They were divided into four groups: 27-31 weeks (42 cases), 32-33 weeks (48 cases), 34-36 weeks (110 cases), and 37-41 weeks (160 cases). Venous blood was collected within 2-4 h after birth to measure serum phosphorus (phosphomolybdate method), 25-OHD (enzyme-linked immunosorbent assay [ELISA]), and ALP (rate method). Maternal pregnancy and delivery-related factors, neonatal birth weight, and Apgar scores were collected. Data analysis was performed using univariate linear regression, Spearman correlation analysis, restricted cubic splines (RCS), and piecewise regression. The <34 weeks subgroup was used as the primary analysis for the preterm turning point, while the full-cohort model was retained as an exploratory/descriptive reference. An unadjusted model was fitted as a sensitivity analysis. RESULTS: Serum phosphorus, 25-OHD, and ALP differed significantly across gestational age groups (all p < 0.001). Serum phosphorus was highest in the 27-31 weeks group (2.12 +/- 0.44 mmol/L), lowest in the 32-33 weeks group (1.78 +/- 0.35 mmol/L), and rebounded thereafter. Post-hoc Tukey's tests showed that serum phosphorus was significantly lower in the 32-33 weeks group and the 34-36 weeks group compared with the 27-31 weeks group (both Tukey-adjusted p < 0.05). Birth weight, Apgar score, and maternal vitamin D/calcium supplementation were positively correlated with serum phosphorus (all p < 0.001). In the primary analysis restricted to infants <34 weeks (n = 90), both the adjusted and unadjusted models converged at a breakpoint of approximately 32.2 weeks (bootstrap 95% CI for the piecewise breakpoint: 30.8-33.6 weeks). CONCLUSIONS: Gestational age and serum phosphorus show a U-shaped non-linear relationship. In preterm infants (<34 weeks), the turning point is consistently estimated at approximately 32 weeks, with the most rapid decline occurring before this age. Preterm infants <32 weeks may benefit from enhanced phosphorus monitoring; these exploratory, single-center findings require validation in larger cohorts. FAU - Zhou, Feng AU - Zhou F AD - Department of Neonatology, Shijiazhuang Fourth Hospital, Shijiazhuang, Hebei, China. FAU - Shen, CunCun AU - Shen C AD - Department of Neonatology, Shijiazhuang Fourth Hospital, Shijiazhuang, Hebei, China. FAU - Chen, HuiFen AU - Chen H AD - Department of Neonatology, Shijiazhuang Fourth Hospital, Shijiazhuang, Hebei, China. FAU - Zhang, HuiFeng AU - Zhang H AD - Department of Pediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. FAU - Han, Xiao AU - Han X AD - Department of Pediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. FAU - Han, LiPing AU - Han L AD - Department of Neonatology, Shijiazhuang Fourth Hospital, Shijiazhuang, Hebei, China. FAU - Wang, Yan AU - Wang Y AD - Department of Neonatology, Shijiazhuang Fourth Hospital, Shijiazhuang, Hebei, China. LA - eng PT - Journal Article DEP - 20261029 PL - England TA - J Matern Fetal Neonatal Med JT - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JID - 101136916 RN - 27YLU75U4W (Phosphorus) RN - 1406-16-2 (Vitamin D) RN - EC 3.1.3.1 (Alkaline Phosphatase) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Humans MH - Infant, Newborn MH - *Phosphorus/blood MH - Female MH - *Gestational Age MH - Prospective Studies MH - Pregnancy MH - *Vitamin D/blood/analogs & derivatives MH - Alkaline Phosphatase/blood MH - Male MH - Adult MH - Birth Weight MH - Apgar Score OTO - NOTNLM OT - Newborn OT - gestational age OT - non-linear relationship OT - restricted cubic splines OT - serum phosphorus EDAT- 2026/10/29 15:20 MHDA- 2026/10/29 15:21 CRDT- 2026/10/29 06:28 PHST- 2026/10/29 15:21 [medline] PHST- 2026/10/29 15:20 [pubmed] PHST- 2026/10/29 06:28 [entrez] AID - 10.1080/14767058.2026.2746880 [doi] PST - ppublish SO - J Matern Fetal Neonatal Med. 2026 Dec;39(1):2746880. doi: 10.1080/14767058.2026.2746880. Epub 2026 Oct 29. PMID- 42953630 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261029 LR - 20261029 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - From sport to everyday movement: a school-based "DON'T STAY STILL!" initiative to address sedentary behavior in children. PG - 1979089 LID - 10.3389/fspor.2026.1979089 [doi] LID - 1979089 AB - INTRODUCTION: Sedentary behavior is a relevant health concern in childhood and adolescence and may remain high even among children who participate in structured physical activity. Schools therefore represent a key setting for reducing prolonged sitting by integrating brief opportunities for movement into everyday routines. "DON'T STAY STILL!" was developed as a school-based pathway specifically targeting sedentary behavior through short, feasible, and inclusive "moments of movement." METHODS: The initiative was implemented during the 2025-2026 school year within the 63rd edition of the "Trofei di Milano-Cortina 2026" programme. Teachers received the PODiaCar "DON'T STAY STILL!" educational guide and supporting videos and incorporated brief active breaks into routine school activities. Students were also involved through drawings and short videos focused on movement and active lifestyles. Programme participation, implementation, and teacher feedback were assessed descriptively; no objective pre/post measures of sedentary behavior or physical activity were collected. RESULTS: The overall programme involved 118 schools and 61,053 students aged 6-13 years, 52% of whom were girls. Within this network, the "DON'T STAY STILL!" pathway generated 2,992 student outputs, including individual and class drawings and videos, while 3,090 students participated in guided "moments of movement" during school-based educational sessions using PODiaCar video exercises. Teacher feedback was positive, although acceptability was not assessed using a validated questionnaire. CONCLUSIONS: "DON'T STAY STILL!" provides a feasible school-based approach for addressing sedentary behavior by embedding brief movement opportunities into routine educational activities. Its implementation within a large and diverse school network, together with substantial student participation and positive teacher feedback, supports its potential as a scalable strategy for promoting more active school environments. The findings support feasibility, participation, and preliminary acceptability, but do not establish effectiveness in reducing sedentary behavior. Future prospective studies should assess its effects on sedentary time, physical activity, and related behavioral and health outcomes. CI - (c) 2026 Zuccotti, Ascani, Romeo, PODiaCar Team and Calcaterra. FAU - Zuccotti, Gianvincenzo AU - Zuccotti G AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. FAU - Ascani, Franco Bruno AU - Ascani FB AD - International Federation of Sport Cinema and Television, Milan, Italy. FAU - Romeo, Assunta Ferdinanda AU - Romeo AF AD - International Federation of Sport Cinema and Television, Milan, Italy. CN - PODiaCar Team FAU - Calcaterra, Valeria AU - Calcaterra V AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. AD - Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy. LA - eng PT - Journal Article DEP - 20261014 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13714929 OTO - NOTNLM OT - active break OT - children OT - physical activity OT - school OT - sedentary behavior COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/29 15:20 MHDA- 2026/10/29 15:21 PMCR- 2026/10/14 CRDT- 2026/10/29 06:08 PHST- 2026/08/26 00:00 [received] PHST- 2026/09/14 00:00 [revised] PHST- 2026/09/30 00:00 [accepted] PHST- 2026/10/29 15:21 [medline] PHST- 2026/10/29 15:20 [pubmed] PHST- 2026/10/29 06:08 [entrez] PHST- 2026/10/14 00:00 [pmc-release] AID - 10.3389/fspor.2026.1979089 [doi] PST - epublish SO - Front Sports Act Living. 2026 Oct 14;8:1979089. doi: 10.3389/fspor.2026.1979089. eCollection 2026. PMID- 42953538 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261029 LR - 20261029 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 9 DP - 2026 Sep TI - Emerging Trends in Pediatric Disease Management and Preventive Care: A Systematic Review. PG - e117058 LID - 10.7759/cureus.117058 [doi] LID - e117058 AB - Child health systems are undergoing rapid transformation driven by biomedical innovation, digital integration, and strengthened preventive strategies. Over the past decade, advances in vaccination, pharmacological therapies, digital monitoring, artificial intelligence-assisted diagnostics, and school-based health programs have reshaped pediatric care delivery. Despite expanding technological capacity and structured prevention models, evidence remains fragmented across clinical, behavioural, and diagnostic domains. Long-term effectiveness, sustainability, and equitable implementation of emerging tools remain insufficiently synthesised within a unified framework. This systematic review synthesises contemporary evidence published between 2015 and 2025 to examine evolving approaches to pediatric disease management and prevention. A structured protocol guided database searches, study selection, and quality appraisal. Randomised controlled trials, cluster trials, feasibility studies, and diagnostic accuracy studies involving pediatric populations were included. Risk of bias was assessed using validated appraisal frameworks appropriate to the study design. Ten studies met the eligibility criteria. Interventions demonstrated measurable improvements in vaccine efficacy, respiratory infection reduction, obesity-related outcomes, injury prevention, asthma adherence, and diagnostic accuracy using artificial intelligence models. Digital and behavioural strategies showed promising trends, although long-term validation and scalability data were limited. These findings underscore the convergence of prevention-focused frameworks and technology-supported care models. Strengthening implementation strategies, harmonising outcome reporting, and prioritising equitable access will be essential for optimising future pediatric health systems. CI - Copyright (c) 2026, Kalaivendan et al. FAU - Kalaivendan, Aravindan AU - Kalaivendan A AD - Department of Pediatrics, Kauvery Hospital, Chennai, IND. FAU - Visveswaran, Thiyagaraajan AU - Visveswaran T AD - Department of Pediatrics, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission's Research Foundation (Deemed to be University), Puducherry, IND. FAU - Krishnan, Suvadha AU - Krishnan S AD - Department of Pediatrics, Aarupadai Veedu Medical College and Hospital, Vinayaka Mission's Research Foundation (Deemed to be University), Puducherry, IND. FAU - Marupudi, Lasya AU - Marupudi L AD - Department of Pharmacy Practice, Sri Venkateshwara College of Pharmacy, affiliated with Osmania University, Hyderabad, IND. FAU - Shukla, Ashish Kumar AU - Shukla AK AD - Department of Radiodiagnosis, Santosh Medical College, Santosh Deemed to be University, Ghaziabad, IND. FAU - Shah, Jacqueline A AU - Shah JA AD - Department of Pediatrics, Indira Gandhi Institute of Child Health, Bengaluru, IND. LA - eng PT - Journal Article PT - Review DEP - 20260928 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13714733 OTO - NOTNLM OT - artificial intelligence OT - digital health OT - pediatric care OT - preventive medicine OT - systematic review COIS- Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/10/29 15:20 MHDA- 2026/10/29 15:21 PMCR- 2026/09/28 CRDT- 2026/10/29 06:01 PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/29 15:21 [medline] PHST- 2026/10/29 15:20 [pubmed] PHST- 2026/10/29 06:01 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - 10.7759/cureus.117058 [doi] PST - epublish SO - Cureus. 2026 Sep 28;18(9):e117058. doi: 10.7759/cureus.117058. eCollection 2026 Sep. PMID- 42952966 OWN - NLM STAT- MEDLINE DCOM- 20261029 LR - 20261029 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Parental health literacy and advanced bone age among school-aged children with overweight or obesity: a cross-sectional study. PG - 1946206 LID - 10.3389/fpubh.2026.1946206 [doi] LID - 1946206 AB - BACKGROUND: Existing studies have shown that parental health literacy is closely associated with the development of childhood overweight and obesity. Childhood overweight and obesity, in turn, can lead to a range of health outcomes, including adult obesity, type 2 diabetes, and advanced bone age. However, no studies have yet examined the relationship between parental health literacy and advanced bone age in overweight and obese children. METHODS: Overweight and obese children were classified into two groups based on whether their bone age was advanced. Baseline characteristics between the two groups were compared. Multivariate logistic regression was used to analyze the association between health literacy and advanced bone age. Multivariate linear regression was performed for sensitivity analyses, with sequential adjustment for age, sex, BMI SDS, and other factors. Receiver operating characteristic (ROC) curve analysis was used to evaluate the discriminative ability of parental health literacy for advanced bone age. Finally, stratified analyses were conducted to assess differences in the strength of the association across subgroups. RESULTS: Higher levels of parental health literacy were associated with a lower risk of advanced bone age in children. Paternal health literacy was influenced by confounding factors, whereas maternal health literacy showed a more consistent association across the fitted models. However, the formal comparison showed no statistically significant difference between the regression coefficients for maternal and paternal health literacy (chi (2) = 0.444, p = 0.505). Exploratory ROC curve analysis showed that adding maternal health literacy to a model based on basic characteristics improved discriminative ability (AUC = 0.734), compared with adding paternal health literacy (AUC = 0.717) or combining both parents' health literacy (AUC = 0.733). The negative association between maternal health literacy and advanced bone age was more pronounced among mothers with higher educational levels. CONCLUSION: These findings suggest that, in pediatric nursing practice, parental health literacy, particularly maternal health literacy, can be improved through health education and other approaches to better support healthy skeletal growth and development in overweight and obese children. CI - Copyright (c) 2026 Wang, Wang, Liang and An. FAU - Wang, Dan AU - Wang D AD - Department of Pediatrics, Xijing Hospital, the Fourth Military Medical University, Xi'an, China. FAU - Wang, Simin AU - Wang S AD - Department of Pediatrics, Xijing Hospital, the Fourth Military Medical University, Xi'an, China. FAU - Liang, Juan AU - Liang J AD - Department of Pediatrics, Xijing Hospital, the Fourth Military Medical University, Xi'an, China. FAU - An, Lu AU - An L AD - Department of Pediatrics, Xijing Hospital, the Fourth Military Medical University, Xi'an, China. LA - eng PT - Journal Article DEP - 20261014 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - *Health Literacy/statistics & numerical data MH - Male MH - *Parents/psychology MH - Cross-Sectional Studies MH - Child MH - *Pediatric Obesity/epidemiology MH - *Age Determination by Skeleton MH - *Overweight MH - Adult PMC - PMC13713633 OTO - NOTNLM OT - age determination by skeleton OT - health literacy OT - parents OT - pediatric nursing OT - pediatric obesity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/29 15:20 MHDA- 2026/10/29 15:21 PMCR- 2026/10/14 CRDT- 2026/10/29 05:26 PHST- 2026/07/23 00:00 [received] PHST- 2026/09/14 00:00 [revised] PHST- 2026/09/22 00:00 [accepted] PHST- 2026/10/29 15:21 [medline] PHST- 2026/10/29 15:20 [pubmed] PHST- 2026/10/29 05:26 [entrez] PHST- 2026/10/14 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1946206 [doi] PST - epublish SO - Front Public Health. 2026 Oct 14;14:1946206. doi: 10.3389/fpubh.2026.1946206. eCollection 2026. PMID- 42952641 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261029 LR - 20261029 IS - 2813-0146 (Electronic) IS - 2813-0146 (Linking) VI - 6 DP - 2026 TI - Strategies to support implementation of an intervention embedding healthy eating and activity content within community-based home visiting. PG - 1951390 LID - 10.3389/frhs.2026.1951390 [doi] LID - 1951390 AB - INTRODUCTION: Embedding evidence-based health interventions within community-based home visiting models offers opportunities to leverage the expertise of these organizations to support reach, trust, and sustainability. This is particularly the case for mothers facing barriers to healthcare access. This study used a Designing for Dissemination and Sustainability approach and the Implementation Strategies Applied in Communities (ISAC) compilation to describe implementation strategies and perspectives of these strategies to support a healthy eating and active living intervention (HEALTH) embedded within Parents as Teachers (PAT), a national community-based home visiting model serving families from pregnancy through early childhood. METHODS: Implementation determinants were informed by prior mixed-methods work and stakeholder engagement with the PAT National Center, affiliate staff (supervisors and parent educators), and annual conference participants. An anonymous 5-item survey administered at the 2025 PAT Annual Conference assessed stakeholder perceptions of proposed implementation strategies. Participants rated strategies on perceived impact and feasibility and reported role and community type. Descriptive analyses were conducted. RESULTS: Forty-nine participants from 18 states completed the survey; most were parent educators. Across strategies, training on implementing the intervention and materials to support supervisors for reflexive supervision were rated as the most impactful and feasible. Communities of practice, parent educator team meetings, and resource connection supports were viewed as highly impactful but somewhat less feasible. Ratings were generally similar across rural and mixed or urban settings, and parent educators often rating strategies as more feasible than supervisors or leaders. DISCUSSION: Findings suggest that leveraging existing organizational infrastructure, especially training, reflective supervision, and peer learning supports, may facilitate implementation of health-related interventions in community settings. Stakeholder input was essential for tailoring strategies to workforce role and context. These results can inform future implementation planning for HEALTH and similar interventions embedded in community-based organizations. CI - (c) 2026 Tabak, Gilbert, Morshed, Farabi, Schwarz, Kemner and Haire-Joshu. FAU - Tabak, Rachel G AU - Tabak RG AD - Prevention Research Center, Washington University in St. Louis Bursky School of Public Health, St. Louis, MO, United States. AD - Center for Diabetes Translation Research, Washington University in St. Louis Bursky School of Public Health, St. Louis, MO, United States. FAU - Gilbert, Amanda AU - Gilbert A AD - Prevention Research Center, Washington University in St. Louis Bursky School of Public Health, St. Louis, MO, United States. FAU - Morshed, Alexandra B AU - Morshed AB AD - Department of Behavioral, Social, and Health Education Sciences, Rollins School of Public Health, Emory University, Atlanta, GA, United States. FAU - Farabi, Sarah S AU - Farabi SS AD - Center for Diabetes Translation Research, Washington University in St. Louis Bursky School of Public Health, St. Louis, MO, United States. AD - Goldfarb School of Nursing at Barnes-Jewish College, St. Louis, MO, United States. AD - Center for Human Nutrition, Washington University in St. Louis School of Medicine, St. Louis, MO, United States. FAU - Schwarz, Cynthia D AU - Schwarz CD AD - Center for Diabetes Translation Research, Washington University in St. Louis Bursky School of Public Health, St. Louis, MO, United States. FAU - Kemner, Allison AU - Kemner A AD - Parents as Teachers National Center, St. Louis, MO, United States. FAU - Haire-Joshu, Debra AU - Haire-Joshu D AD - Center for Diabetes Translation Research, Washington University in St. Louis Bursky School of Public Health, St. Louis, MO, United States. LA - eng PT - Journal Article DEP - 20261014 PL - Switzerland TA - Front Health Serv JT - Frontiers in health services JID - 9918334887706676 PMC - PMC13713495 OTO - NOTNLM OT - dissemination OT - healthy eating OT - home-visiting OT - implementation and sustainability OT - implementation science OT - physical activity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/29 15:20 MHDA- 2026/10/29 15:21 PMCR- 2026/10/14 CRDT- 2026/10/29 05:04 PHST- 2026/07/28 00:00 [received] PHST- 2026/09/15 00:00 [revised] PHST- 2026/09/22 00:00 [accepted] PHST- 2026/10/29 15:21 [medline] PHST- 2026/10/29 15:20 [pubmed] PHST- 2026/10/29 05:04 [entrez] PHST- 2026/10/14 00:00 [pmc-release] AID - 10.3389/frhs.2026.1951390 [doi] PST - epublish SO - Front Health Serv. 2026 Oct 14;6:1951390. doi: 10.3389/frhs.2026.1951390. eCollection 2026. PMID- 42952194 OWN - NLM STAT- MEDLINE DCOM- 20261029 LR - 20261029 IS - 1462-3994 (Electronic) IS - 1462-3994 (Linking) VI - 28 DP - 2026 Oct 29 TI - Evaluating Alignment of Prader-Willi Syndrome with the Australian Newborn Bloodspot Screening Criteria. PG - e52 LID - 10.1017/erm.2026.10080 [doi] AB - BACKGROUND: Prader-Willi syndrome (PWS) is a leading genetic cause of life-threatening obesity, presenting with hypotonia and feeding difficulties in infancy, progressing to hyperphagia, cognitive impairment and behavioural challenges from childhood. It is a rare imprinting disorder caused by gene silencing at the 15q11-q13 locus. Early detection through newborn bloodspot screening (NBS) could enable timely interventions such as growth hormone therapy, dietary management and behavioural support to improve health and developmental outcomes for the affected infants. METHODS: This review applies the Australian Newborn Bloodspot Screening National Policy Framework as a reference to evaluate the suitability of incorporating PWS into NBS programs. The review outlines benefits and challenges in relation to key criteria used by this Framework, including condition severity, early detection benefits and screening test reliability. RESULTS: Emerging screening technologies are recognised for their high sensitivity and specificity and could be integrated into existing NBS workflows using dried blood spots. However, several challenges outlined in this review need to be addressed, including the lack of cost-effectiveness data for population-wide PWS screening programs and the absence of a curative treatment for PWS. CONCLUSION: Expanding NBS to include PWS has the potential to improve health and developmental outcomes through earlier diagnosis and timely interventions. Successful implementation will depend on addressing the remaining challenges. FAU - Alshawsh, Mohammed A AU - Alshawsh MA AUID- ORCID: 0000-0001-8342-5183 AD - Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, VIC, Australia. AD - Department of Paediatrics, Monash University, Clayton, VIC, Australia. ROR: https://ror.org/019wvm592 FAU - Tennakoon, Oshadi AU - Tennakoon O AUID- ORCID: 0009-0006-2052-4305 AD - Division of Genome Sciences and Cancer, The John Curtin School of Medical Research, The Australian National University, ACT, Australia. ROR: https://ror.org/03f0f6041 FAU - Arora, Sheena AU - Arora S AUID- ORCID: 0000-0002-7562-2416 AD - Centre for Health Economics Research and Evaluation, University of Technology Sydney, Broadway, NSW, Australia. ROR: https://ror.org/03f0f6041 FAU - Greaves, Ronda F AU - Greaves RF AUID- ORCID: 0000-0001-7823-8797 AD - Department of Paediatrics, Monash University, Clayton, VIC, Australia. ROR: https://ror.org/019wvm592 AD - Victorian Clinical Genetics Services,Murdoch Children's Research Institute, Parkville, VIC, Australia. AD - Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. FAU - Cheong, Jeanie AU - Cheong J AUID- ORCID: 0000-0001-5901-0455 AD - Department of Paediatrics, Monash University, Clayton, VIC, Australia. ROR: https://ror.org/019wvm592 AD - Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. AD - Department of Obstetrics, Gynaecology and Newborn Health, The Royal Women's Hospital, Parkville, VIC, Australia. FAU - Williams, Katrina AU - Williams K AUID- ORCID: 0000-0002-1686-4458 AD - Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, VIC, Australia. AD - Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. FAU - Godler, David E AU - Godler DE AUID- ORCID: 0000-0002-6405-269X AD - Murdoch Children's Research Institute, The Royal Children's Hospital, Parkville, VIC, Australia. AD - Department of Paediatrics, Monash University, Clayton, VIC, Australia. ROR: https://ror.org/019wvm592 AD - Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. LA - eng GR - No. 1049299 and No. 1103389/National Health and Medical Research Council/ GR - 2017-361/Financial Markets Foundation for Children/ PT - Journal Article PT - Review DEP - 20261029 PL - England TA - Expert Rev Mol Med JT - Expert reviews in molecular medicine JID - 100939725 SB - IM MH - Humans MH - *Prader-Willi Syndrome/diagnosis/genetics/blood/epidemiology MH - *Neonatal Screening/methods MH - Infant, Newborn MH - Australia/epidemiology MH - Genetic Testing/methods OTO - NOTNLM OT - Australian decision-making criteria OT - DNA methylation testing OT - Prader-Willi syndrome OT - chromosome 15 imprinting disorders OT - newborn bloodspot screening EDAT- 2026/10/29 05:30 MHDA- 2026/10/29 05:31 CRDT- 2026/10/29 02:23 PHST- 2026/10/29 05:31 [medline] PHST- 2026/10/29 05:30 [pubmed] PHST- 2026/10/29 02:23 [entrez] AID - S1462399426100805 [pii] AID - 10.1017/erm.2026.10080 [doi] PST - epublish SO - Expert Rev Mol Med. 2026 Oct 29;28:e52. doi: 10.1017/erm.2026.10080. PMID- 42951837 OWN - NLM STAT- MEDLINE DCOM- 20261028 LR - 20261028 IS - 1476-4954 (Electronic) IS - 1476-4954 (Linking) VI - 39 IP - 1 DP - 2026 Dec TI - Association of third-trimester maternal lipid levels with adverse pregnancy outcomes in women with gestational diabetes mellitus: a retrospective single-center study using intrapartum data. PG - 2751278 LID - 10.1080/14767058.2026.2751278 [doi] AB - OBJECTIVES: This study investigates the relationships between maternal factors and gestational diabetes mellitus (GDM), as well as third‑trimester maternal lipids and adverse pregnancy outcomes among GDM patients. METHODS: This study enrolled 3,973 pregnant women, divided into a control group (n = 3166) and a GDM group (n = 807). The GDM group was further divided into well-controlled (n = 152) and poorly controlled subgroups (n = 655). Univariate and multivariate logistic regression analyses were performed to evaluate factors associated with GDM risk. Baseline clinical/laboratory characteristics were compared across groups via parametric, nonparametric, and chi‑square tests to assess associations of third‑trimester maternal lipid levels with adverse pregnancy outcomes. Receiver operating characteristic analyses evaluated the predictive values of body mass index (BMI) and third‑trimester maternal lipid levels. RESULTS: Age (OR = 1.069, 95% CI:1.050-1.087, p < .001), overweight (OR = 1.678 95% CI:1.396-2.013, p < .001), and obesity (OR = 2.018, 95% CI:1.511-2.677, p < .001) are key risk factors for GDM. Significant differences existed in age (p = .001), BMI (p < .001), fasting blood glucose (FBG, p < .001) and 2-hour postprandial plasma glucose (2hPPG, p = .001) across subgroups, as well as triglycerides (TG, p < .001), high-density lipoprotein cholesterol (HDL-C, p = .001), and free fatty acids (FFAs, p < .001) among the three groups. Subgroup analysis by lipid levels showed TG predominantly affected delivery mode (p = .031), neonatal birth weight (p = .005), and quantitative blood loss (QBL, p = .019) in GDM, while HDL-C mainly influenced fetal growth curve (p = .004) and neonatal birth weight (p = .002). Subgroup analysis by triglyceride-glucose index (TyG index) revealed significant differences in glycemic control (p = .002), delivery mode (p = .002), neonatal weight (p = .005), and QBL (p = .005). The area under the curve of pre-pregnancy BMI for GDM complicated by hypertensive disorders of pregnancy was 0.738, third-trimester BMI 0.720, and 0.709 for macrosomia prediction in non-advanced-age women with GDM. CONCLUSION: Age, overweight, and obesity are independent risk factors for GDM. Among women with GDM, third-trimester lipid levels are associated with adverse pregnancy outcomes. Therefore, lipid levels should be considered in GDM clinical management, rather than focusing exclusively on glycemic control. FAU - Yang, Yuqi AU - Yang Y AUID- ORCID: 0000-0002-7619-9541 AD - Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China. AD - Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China. FAU - Peng, Yue AU - Peng Y AD - Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China. FAU - Fan, Jiuxiang AU - Fan J AD - Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China. FAU - Zhang, Jian AU - Zhang J AD - Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China. FAU - Zhu, Wei AU - Zhu W AUID- ORCID: 0000-0002-5237-1992 AD - Department of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang, Jiangsu, China. FAU - Yu, Bin AU - Yu B AD - Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, Jiangsu, China. LA - eng PT - Journal Article DEP - 20261028 PL - England TA - J Matern Fetal Neonatal Med JT - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JID - 101136916 RN - 0 (Lipids) RN - 0 (Triglycerides) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Diabetes, Gestational/blood/epidemiology MH - Adult MH - Retrospective Studies MH - *Pregnancy Outcome/epidemiology MH - *Pregnancy Trimester, Third/blood MH - *Lipids/blood MH - Body Mass Index MH - Risk Factors MH - Case-Control Studies MH - Triglycerides/blood MH - Infant, Newborn OTO - NOTNLM OT - Gestational diabetes mellitus OT - high-density lipoprotein cholesterol OT - lipid metabolism OT - triglyceride OT - triglyceride-glucose index EDAT- 2026/10/29 05:30 MHDA- 2026/10/29 05:31 CRDT- 2026/10/28 23:23 PHST- 2026/10/29 05:31 [medline] PHST- 2026/10/29 05:30 [pubmed] PHST- 2026/10/28 23:23 [entrez] AID - 10.1080/14767058.2026.2751278 [doi] PST - ppublish SO - J Matern Fetal Neonatal Med. 2026 Dec;39(1):2751278. doi: 10.1080/14767058.2026.2751278. Epub 2026 Oct 28. PMID- 42950072 OWN - NLM STAT- Publisher LR - 20261028 IS - 1536-0911 (Electronic) IS - 1536-0903 (Linking) DP - 2026 Oct 27 TI - Predictors and Risk Factors of Necrotizing Enterocolitis: An Integrative Review. LID - 10.1097/ANC.0000000000001441 [doi] AB - BACKGROUND: Necrotizing enterocolitis (NEC) is associated with high morbidity and mortality among preterm infants. Early intervention is critical, but existing predictors and risk factors remain inconsistent. Integrating bedside nursing assessments with machine learning (ML) may enable prediction of NEC before deterioration. PURPOSE: This integrative review synthesizes evidence on predictors and risk factors of NEC in very low birth weight (VLBW; <1500 g) infants to guide ML-based prediction models, support nursing assessment, and support early clinical decision making. DATA SOURCES: MEDLINE, CINAHL, and Embase. STUDY SELECTION: We included quantitative studies published from 2015 to 2025, involving VLBW infants <32 weeks gestation and examining NEC predictors or risk factors. From 405 records, 325 abstracts were screened, and 14 studies met inclusion criteria. DATA EXTRACTION: Two reviewers independently assessed full texts, resolving differences through consensus. Data were organized thematically using an inductive approach with a predetermined extraction table. Study quality was evaluated with a Joanna Briggs Institute tool. RESULTS: Across 14 studies, 55 predictors or risk factors were identified. Gestational age, birth weight, and human milk exposure were consistently associated with NEC risk. Other maternal, antenatal, delivery, nutritional, social, and clinical variables varied widely, with only 16 factors appearing in multiple studies. Most studies used retrospective cohort designs, and one incorporated ML methods. IMPLICATIONS FOR PRACTICE AND RESEARCH: Nurses are central to NEC prevention through human milk promotion, risk surveillance, and bedside advocacy. Future NEC prediction should integrate dynamic, contextual variables with standardized definitions and validation across diverse settings. CI - Copyright (c) 2026 by The National Association of Neonatal Nurses. FAU - Fordham, Keliy AU - Fordham K AUID- ORCID: 0000-0002-0286-596 AD - Author Affiliations: College of Nursing, University of Florida, Gainesville, FL (Fordham, Monk, Bjarnadottir, Yao, and Parker); Tampa General Hospital, Tampa, Florida (Cousin); and College of Industrial and Systems Engineering, University of Florida, Gainesville, Florida (Zhong). FAU - Monk, Angela AU - Monk A FAU - Bjarnadottir, Ragnhildur I AU - Bjarnadottir RI FAU - Cousin, Lakeshia AU - Cousin L FAU - Zhong, Xiang AU - Zhong X FAU - Yao, Yingwei AU - Yao Y FAU - Parker, Leslie A AU - Parker LA LA - eng PT - Journal Article DEP - 20261027 PL - United States TA - Adv Neonatal Care JT - Advances in neonatal care : official journal of the National Association of Neonatal Nurses JID - 101125644 SB - IM OTO - NOTNLM OT - infant OT - machine learning OT - necrotizing enterocolitis OT - nursing assessment OT - risk factors OT - very low birth weight EDAT- 2026/10/28 17:31 MHDA- 2026/10/28 17:31 CRDT- 2026/10/28 14:04 PHST- 2026/10/28 17:31 [medline] PHST- 2026/10/28 17:31 [pubmed] PHST- 2026/10/28 14:04 [entrez] AID - 00149525-990000000-00327 [pii] AID - 10.1097/ANC.0000000000001441 [doi] PST - aheadofprint SO - Adv Neonatal Care. 2026 Oct 27. doi: 10.1097/ANC.0000000000001441. PMID- 42948496 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261028 LR - 20261029 IS - 2639-6378 (Electronic) IS - 2639-6378 (Linking) VI - 12 IP - 4 DP - 2026 Oct TI - Building a Sustainable Teen Wellness Curriculum in a Faith-Based Community Setting : A Six-Year Program Evaluation in Wilmington, Delaware. PG - 79-81 LID - 10.32481/djph.2026.10.10 [doi] AB - In the United States, the need for adolescent mental health support is greater than what clinical services can provide, with about one in five teens reporting unmet needs. Faith-based organizations are trusted and easy to access, but evidence on sustained delivery is limited. This report looks at a volunteer-led teen wellness program at Manna House Fellowship in Wilmington, Delaware, which ran from June 2020 to July 2026. The program offered 30-minute interactive small-group sessions every two weeks during active cycles, focusing on sleep, nutrition, physical activity, screen and social media use, and stress coping. Sessions were held online until March 2022, then in person. Over six years, 78 sessions reached 35 different teens, averaging eight participants per session, with most attending more than once. Anonymous feedback was collected monthly in written and verbal formats, and reported changes were noted. No one needed to be referred to formal mental health services. That the program has continued for six years without outside funding or paid staff support the feasibility of this sustained community wellness program, although not its clinical effectiveness. Zero recorded referrals do not establish an absence of unmet mental health needs. CI - 2026 The journal and its content is copyrighted by the Delaware Academy of Medicine & Public Health (the Academy). FAU - Nathaniel, Sangeetha D AU - Nathaniel SD AD - Delaware Heart and Vascular Group, Delaware. AD - Manna House Fellowship, Delaware. AD - ChristianaCare Hospital, Delaware. FAU - Innasimuthu, Michelle AU - Innasimuthu M AD - Delaware Heart and Vascular Group, Delaware. AD - Manna House Fellowship, Delaware. AD - ChristianaCare Hospital, Delaware. FAU - Gnanaguruparan, Subramanian AU - Gnanaguruparan S AD - Delaware Heart and Vascular Group, Delaware. AD - Manna House Fellowship, Delaware. AD - ChristianaCare Hospital, Delaware. LA - eng PT - Journal Article DEP - 20261026 PL - United States TA - Dela J Public Health JT - Delaware journal of public health JID - 101769648 PMC - PMC13712908 EDAT- 2026/10/28 11:36 MHDA- 2026/10/28 11:37 PMCR- 2026/10/26 CRDT- 2026/10/28 05:35 PHST- 2026/10/28 11:37 [medline] PHST- 2026/10/28 11:36 [pubmed] PHST- 2026/10/28 05:35 [entrez] PHST- 2026/10/26 00:00 [pmc-release] AID - djph-124-10 [pii] AID - 10.32481/djph.2026.10.10 [doi] PST - epublish SO - Dela J Public Health. 2026 Oct 26;12(4):79-81. doi: 10.32481/djph.2026.10.10. eCollection 2026 Oct. PMID- 42948365 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261028 LR - 20261029 IS - 1792-1015 (Electronic) IS - 1792-0981 (Print) IS - 1792-0981 (Linking) VI - 32 IP - 6 DP - 2026 Dec TI - Associations of reticulocyte hemoglobin equivalent with erythrocyte indices and serum ferritin in anemic patients with hepatocellular carcinoma: A retrospective study. PG - 340 LID - 10.3892/etm.2026.13335 [doi] LID - 340 AB - Cancer-related anemia is common in patients with hepatocellular carcinoma (HCC), and its pathogenesis is complex due to the coexistence of chronic liver disease, portal hypertension, hypersplenism, inflammation, nutritional disorders and tumor-related factors. The present retrospective study characterized anemia morphology in 96 anemic patients with HCC before initiation of their first antitumor therapy, and examined the associations of reticulocyte hemoglobin equivalent (RET-He) with erythrocyte indices and serum ferritin (SF), with a focus on whether RET-He and SF displayed distinct patterns of association with hematological parameters. The data collected included sex, age, Barcelona Clinic Liver Cancer stage, Child-Pugh grade, splenomegaly/hypersplenism, hemoglobin (Hb) concentration, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), MCH concentration (MCHC), absolute reticulocyte count (RET#), RET-He and SF. Patients were compared by anemia severity, morphological type and RET-He level, and Spearman'a correlation was used to assess relationships between RET-He and other parameters. Mild, moderate and severe anemia occurred in 41 (42.71%), 52 (54.17%) and 3 (3.13%) patients, respectively. Macrocytic, normocytic, simple microcytic and microcytic hypochromic anemia were found in 29 (30.21%), 40 (41.67%), 5 (5.21%) and 22 (22.92%) patients, respectively. A total of 26 patients (27.08%) had RET-He 2 years), bottle-feeding, and inadequate oral hygiene practices (infrequent or unsupervised brushing and use of non-fluoridated toothpaste) were identified as key behavioral indicators significantly associated with increased S-ECC (P < 0.05). Furthermore, lower nutritional status and higher defs indices were strongly associated with poorer OHRQoL scores (P < 0.001). CONCLUSIONS: S-ECC and poor nutrition were prevalent among 4-5-year-olds, strongly associated with dietary habits, oral hygiene practices, and maternal education, while both conditions correlated with lower oral health-related quality of life. Importantly, higher ECC and poor nutrition were interrelated, highlighting the potential utility of integrated oral health and nutritional interventions in clinical pediatric settings. CI - (c) 2026. The Author(s). FAU - Nadeeshani, Harshani AU - Nadeeshani H AD - Nutritional Biochemistry Research Program, National Institute of Fundamental Studies, Kandy, Sri Lanka. AD - Department of Community Dental Health, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Narada, Malinda AU - Narada M AD - Department of Community Dental Health, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Gunawardena, Sadhisha AU - Gunawardena S AD - Nutritional Biochemistry Research Program, National Institute of Fundamental Studies, Kandy, Sri Lanka. FAU - De Alwis, Sudam AU - De Alwis S AD - Nutritional Biochemistry Research Program, National Institute of Fundamental Studies, Kandy, Sri Lanka. FAU - Dias, Chathumini AU - Dias C AD - Nutritional Biochemistry Research Program, National Institute of Fundamental Studies, Kandy, Sri Lanka. FAU - Kudagammana, Sanath Thushara AU - Kudagammana ST AD - Department of Paediatrics, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Herath, Chandra AU - Herath C AD - Department of Community Dental Health, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Jayasinghe, Ruwan AU - Jayasinghe R AD - Department of Oral Medicine and Periodontology, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Liyanage, Ruvini AU - Liyanage R AD - Nutritional Biochemistry Research Program, National Institute of Fundamental Studies, Kandy, Sri Lanka. ruvini.li@nifs.ac.lk. LA - eng PT - Journal Article DEP - 20260723 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Humans MH - Child, Preschool MH - Cross-Sectional Studies MH - *Quality of Life MH - Female MH - Male MH - *Dental Caries/epidemiology MH - *Oral Health/statistics & numerical data MH - *Nutritional Status MH - Sri Lanka/epidemiology MH - Oral Hygiene MH - Diet PMC - PMC13715219 OTO - NOTNLM OT - BMI OT - Defs OT - Deft OT - Early childhood caries OT - Oral health-related quality of life COIS- Declarations. Ethics approval and consent to participate: The ethical clearance certificate (ERC/FDS/UOP/I/2021/45) was obtained from the Ethical Review Committee, Faculty of Dental Sciences, University of Peradeniya, on 12th October 2021. According to that, Information regarding the research was conveyed to parents or guardians by a typed information sheet in a manner and a language suitable to the individual's level of understanding. The participants were given adequate opportunity to ask questions, and they were answered honestly and completely. Parents or guardians were made aware that they were free to withdraw their consent at any time without trepidation of consequences. Finally, the consent was obtained as a signature on a consent form that explicitly stated what was being consented to. Participants were not subjected to coercion, inducement, undue influence, or deception at any cost. Consent for publication: Parents or guardians were informed that these data would be published in journal articles, and consent was obtained as a signature on a consent form. Competing interests: The authors declare no competing interests. EDAT- 2026/10/28 05:28 MHDA- 2026/10/28 05:29 PMCR- 2026/07/23 CRDT- 2026/10/28 00:48 PHST- 2026/03/05 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/10/28 05:29 [medline] PHST- 2026/10/28 05:28 [pubmed] PHST- 2026/10/28 00:48 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - 10.1186/s41043-026-01407-6 [pii] AID - 1407 [pii] AID - 10.1186/s41043-026-01407-6 [doi] PST - epublish SO - J Health Popul Nutr. 2026 Jul 23;45(1):238. doi: 10.1186/s41043-026-01407-6. PMID- 42947253 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261028 LR - 20261029 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2026 Oct 27 TI - Cross-group and longitudinal measurement invariance of the Child Eating Behavior Questionnaire-24G in middle childhood. LID - 10.1186/s40337-026-01806-4 [doi] LID - 252 AB - BACKGROUND: Childhood eating behaviors are most commonly assessed using parent-report questionnaires. To validly compare means across different groups or over time, equivalent item functioning is an important prerequisite. This study investigates the measurement invariance of a short German version of the Child Eating Behavior Questionnaire, the CEBQ-24G, across child sex, age, weight status, family socio-economic status, and parental weight status, as well as across three measurement occasions spanning three years in middle childhood. METHODS: Analyses were conducted using a large community sample (N = 1,657) recruited from primary schools in Brandenburg, Germany. Measurement invariance was tested and latent group means were compared using Multigroup Confirmatory Factor Analysis (CFA). RESULTS: The CEBQ-24G is measurement invariant on the residual level across all groups and measurement occasions, i.e., assessed differences in eating behaviors between these groups and measurement occasions are derived from actual differences in latent constructs and not a result of measurement bias-thus allowing valid comparisons of latent means across child sex, age, weight status, parental weight status, and family socio-economic status. We found significant differences in all group comparisons (except between age groups), although the eating behavior scales in which the differences in mean scores occurred varied depending on which groups were compared. CONCLUSIONS: Our findings suggest that the CEBQ-24G has good psychometric properties in all groups and is suitable for research into eating behaviors in middle childhood in diverse populations. CI - (c) 2026. The Author(s). FAU - Ruden, Joyce C AU - Ruden JC AUID- ORCID: 0009-0009-2462-8031 AD - Department of Psychology, Counseling Psychology, University of Potsdam, Potsdam, Germany. FAU - Warschburger, Petra AU - Warschburger P AUID- ORCID: 0000-0001-7979-7451 AD - Department of Psychology, Counseling Psychology, University of Potsdam, Potsdam, Germany. petra.warschburger@uni-potsdam.de. LA - eng PT - Journal Article DEP - 20261027 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC13711984 OAB - The 24-item German adaptation of the Child Eating Behavior Questionnaire (CEBQ-24G) is a tool to assess a child's eating behaviors via parent report. This study examined whether the questionnaire is understood in the same way across different groups and multiple measurements. Such measurement equivalence is required in order to make valid comparisons between eating behaviors across groups and over time. Using a sample of 1,657 children from primary schools in Brandenburg, Germany, we confirmed the questionnaire's measurement equivalence across child sex, age, weight status, family socio-economic status, and parental weight status, as well as across time in middle childhood. This enabled us to compare eating behaviors across these groups. We found differences in eating behaviors based on children's sex, weight status group, their parent's weight status group, and their family's socio-economic status, but not age. Overall, this study demonstrates that the CEBQ-24 validly assesses children's eating behavior in diverse samples and over time. OABL- eng OTO - NOTNLM OT - Child Eating Behavior Questionnaire OT - Childhood OT - Eating behavior OT - Group differences OT - Measurement invariance OT - Multigroup CFA OT - Parent report COIS- Declarations. Ethics approval and consent to participate: Approval was obtained from the ethics committee of the University of Potsdam, Germany (reference numbers 28-33/2011, 3-10/2012, 21/2012, 32/2014, 18/2020, 10/2022, and 37/2022). The procedures used in this study adhere to the tenets of the Declaration of Helsinki. Informed consent was obtained from each participant. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/28 05:28 MHDA- 2026/10/28 05:29 PMCR- 2026/10/27 CRDT- 2026/10/28 00:47 PHST- 2026/06/11 00:00 [received] PHST- 2026/10/18 00:00 [accepted] PHST- 2026/10/28 05:29 [medline] PHST- 2026/10/28 05:28 [pubmed] PHST- 2026/10/28 00:47 [entrez] PHST- 2026/10/27 00:00 [pmc-release] AID - 10.1186/s40337-026-01806-4 [pii] AID - 1806 [pii] AID - 10.1186/s40337-026-01806-4 [doi] PST - epublish SO - J Eat Disord. 2026 Oct 27;14(1):252. doi: 10.1186/s40337-026-01806-4. PMID- 42947061 OWN - NLM STAT- MEDLINE DCOM- 20261028 LR - 20261029 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 31 TI - Effects of school-based nutrition education on self-efficacy, attitudes, food behaviors, and health in children. LID - 10.1186/s12887-026-07412-2 [doi] LID - 1075 AB - BACKGROUND AND AIM: School-based nutrition education programs are commonly used to promote healthy eating behaviors among children; however, their effectiveness may vary according to developmental stage. The present study aimed to evaluate the effects of a school-based nutrition education program on children's dietary self-efficacy (CDSS), dietary attitudes (DAS), food behaviors (FBS), and children self-rated health scale (CSHC). MATERIALS AND METHODS: This study employed a pre-post nutrition intervention design and including 1418 primary and secondary school students from different grade levels. CDSS, DAS, FBS, and CSHC were assessed before and after the nutrition education using validated self-report scales. Changes following the intervention were statistically examined and differences according to grade level and gender were analyzed. RESULTS: Following the nutrition education program, a significant improvement was observed in child nutrition self-efficacy. In contrast, no significant overall changes were found in dietary attitudes, food behaviors, or self-rated health perception. Dietary attitudes and food behaviors differed significantly by grade level both before and after the intervention, with older children's dietary self-efficacy and food behaviors were more evident in certain lower grade levels. No significant differences were observed between girls and boys with respect to dietary attitudes or food behaviors. CONCLUSIONS: The findings suggest that while school-based nutrition education can enhance dietary self-efficacy, short-term educational interventions alone may be insufficient to produce measurable changes in children's eating behaviors. Developmentally tailored, multi-component interventions that incorporate family involvement and environmental factors may be necessary to support sustained improvements in dietary behaviors, particularly among older school-age children. CI - (c) 2026. The Author(s). FAU - Terzi, Merve AU - Terzi M AUID- ORCID: 0000-0003-3397-9692 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Yeni Yuzyil University, Istanbul, Turkey. merve.terzi@yeniyuzyil.edu.tr. FAU - Ergan, Kubra AU - Ergan K AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Yeni Yuzyil University, Istanbul, Turkey. AD - Department of Nutrition and Dietetics, Istinye University, Graduate School, Istanbul, Turkiye. FAU - Demirkesen-Bicak, Hilal AU - Demirkesen-Bicak H AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Yeni Yuzyil University, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20260731 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Male MH - Female MH - *Self Efficacy MH - Child MH - *Feeding Behavior/psychology MH - *Health Education/methods MH - *School Health Services MH - *Health Knowledge, Attitudes, Practice PMC - PMC13715218 OTO - NOTNLM OT - Dietary attitudes OT - Dietary self-efficacy OT - Eating behaviors in children OT - Health-related quality of life OT - School-based nutrition intervention COIS- Declarations. Ethics approval and consent to participate: Ethical approval for this study was obtained from the Istanbul Yeni Yuzyil University Ethics Committee (Approval Number: 2025/03-1511). All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the Declaration of Helsinki and its later amendments. Written informed consent was obtained from the parents/legal guardians of all participants prior to participation in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/10/28 05:28 MHDA- 2026/10/28 05:29 PMCR- 2026/07/31 CRDT- 2026/10/28 00:37 PHST- 2026/05/04 00:00 [received] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/10/28 05:29 [medline] PHST- 2026/10/28 05:28 [pubmed] PHST- 2026/10/28 00:37 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - 10.1186/s12887-026-07412-2 [pii] AID - 7412 [pii] AID - 10.1186/s12887-026-07412-2 [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 31;26(1):1075. doi: 10.1186/s12887-026-07412-2. PMID- 42946529 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261027 IS - 1557-8224 (Electronic) IS - 1089-3261 (Linking) VI - 30 IP - 4 DP - 2026 Nov TI - Metabolic Dysfunction-Associated Steatotic Liver Disease in Children. PG - 987-1007 LID - S1089-3261(26)00071-1 [pii] LID - 10.1016/j.cld.2026.07.009 [doi] AB - Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease among children and adolescents worldwide. Pediatric MASLD is associated with significant morbidity during childhood, including progressive liver fibrosis and incident diabetes, and significantly increases risk of premature mortality in early adulthood. In comparison to MASLD in adults, youth-onset MASLD exhibits distinct histologic patterns, lacks well-validated noninvasive tests for risk stratification and approved pharmacotherapy, and may carry higher risk of long-term liver-related mortality. Critical areas of unmet need include improving rates of recommended screening, development of pediatric-specific risk stratification tools and developing more effective prevention and treatment strategies. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Yodoshi, Toshifumi AU - Yodoshi T AD - Division of Gastroenterology, Hepatology, Pancreatology, and Nutrition, Department of Pediatrics, Stead Family Children's Hospital, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA; Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital, 3333 Burnet Avenue, Cincinnati, OH 45229, USA. FAU - Xanthakos, Stavra AU - Xanthakos S AD - Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. Electronic address: stavra.xanthakos@cchmc.org. LA - eng PT - Journal Article PT - Review DEP - 20260904 PL - United States TA - Clin Liver Dis JT - Clinics in liver disease JID - 9710002 SB - IM MH - Humans MH - Child MH - *Fatty Liver/diagnosis/therapy/epidemiology/etiology MH - Risk Factors MH - Adolescent MH - Liver Cirrhosis/etiology/epidemiology MH - *Non-alcoholic Fatty Liver Disease/diagnosis/therapy/epidemiology MH - Obesity/epidemiology/complications MH - Diabetes Mellitus, Type 2/epidemiology/complications OTO - NOTNLM OT - Fibrosis OT - MASH OT - MASLD OT - Mortality OT - Obesity OT - Type 2 diabetes COIS- Disclosure Dr S. Xanthakos has served as a scientific advisor to Novo Nordisk and Madrigal. Dr T. Yodoshi has nothing to disclose. EDAT- 2026/10/27 23:28 MHDA- 2026/10/27 23:29 CRDT- 2026/10/27 21:54 PHST- 2026/10/27 23:29 [medline] PHST- 2026/10/27 23:28 [pubmed] PHST- 2026/10/27 21:54 [entrez] AID - S1089-3261(26)00071-1 [pii] AID - 10.1016/j.cld.2026.07.009 [doi] PST - ppublish SO - Clin Liver Dis. 2026 Nov;30(4):987-1007. doi: 10.1016/j.cld.2026.07.009. Epub 2026 Sep 4. PMID- 42945754 OWN - NLM STAT- Publisher LR - 20261027 IS - 1873-5487 (Electronic) IS - 0188-4409 (Linking) VI - 58 IP - 1 DP - 2026 Oct 27 TI - Validation of the Healthy Complementary Feeding Practices Index: A Novel Approach for Assessing Infant Feeding in Mexico. PG - 103535 LID - S0188-4409(26)00157-8 [pii] LID - 10.1016/j.arcmed.2026.103535 [doi] AB - OBJECTIVE: To develop and validate the Healthy Complementary Feeding Practices Index (HCFPI), a novel tool designed to assess adherence to Mexico's national dietary guidelines and inform the design of interventions to prevent malnutrition in infants aged 6-24 months. METHODS: The HCFPI was constructed using a literature-based selection of components, indicators, and scoring criteria. Content validity was evaluated using the Delphi method with experts. Internal consistency (Cronbach's alpha) and concurrent validity with dietary intake were examined in a cross-sectional sample from a Mexican birth cohort at 6, 12, and 24 months. RESULTS: The HCFPI comprises 13 components and 15 items that reflect key CF dimensions, and it achieved "acceptable" expert consensus during content validation. The index demonstrated "acceptable" internal consistency (alpha = 0.70) and meaningful correlations with optimal Complementary Feeding (CF) practices, such as breastfeeding, the timely introduction of solids, and the avoidance of both unhealthy salty foods and follow-up formulas. Furthermore, higher HCFPI scores were associated with better dietary quality, including higher fiber intake, greater protein and vitamin B12 adequacy, and lower added sugar intake. CONCLUSION: The HCFPI is a valid, reliable, and practical tool for evaluating adherence to CF recommendations and dietary quality in young children. Its framework offers a model that could be adapted to create similar indices in other countries using evidence-based national dietary guidelines. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Tercero-Gomez, Francia AU - Tercero-Gomez F AD - National Institute of Public Health, Center for Nutrition and Health Research. FAU - Ramirez-Silva, Ivonne AU - Ramirez-Silva I AD - National Institute of Public Health, Center for Nutrition and Health Research. Electronic address: ciarmir@insp.mx. FAU - Rivera, Juan A AU - Rivera JA AD - National Institute of Public Health, Center for population Health Research. FAU - Fuentes-Garcia, Ruth AU - Fuentes-Garcia R AD - Department of Mathematics, Faculty of Science, National Autonomus of Mexico, Mexico City, Mexico. FAU - Perez-Escamilla, Rafael AU - Perez-Escamilla R AD - Yale School of Public Health. Yale University, New Haven, CT. USA. FAU - Olvera-Mayorga, Gabriela AU - Olvera-Mayorga G AD - National Institute of Public Health, Center for Nutrition and Health Research; Nutrition Academic Area, Institute of Health Sciences, Autonomous University of the State of Hidalgo, Mexico. FAU - Barragan-Vazquez, Sofia AU - Barragan-Vazquez S AD - National Institute of Public Health, Center for Nutrition and Health Research; Nutritional Epidemiology Group, School of Food Science and Nutrition, University of Leeds, Woodhouse, Leeds, UK. LA - eng PT - Journal Article DEP - 20261027 PL - United States TA - Arch Med Res JT - Archives of medical research JID - 9312706 SB - IM OTO - NOTNLM OT - Complementary feeding OT - Diet quality OT - Index OT - Infant feeding practices OT - Validation EDAT- 2026/10/27 23:28 MHDA- 2026/10/27 23:28 CRDT- 2026/10/27 19:07 PHST- 2025/10/02 00:00 [received] PHST- 2026/08/10 00:00 [revised] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/10/27 23:28 [medline] PHST- 2026/10/27 23:28 [pubmed] PHST- 2026/10/27 19:07 [entrez] AID - S0188-4409(26)00157-8 [pii] AID - 10.1016/j.arcmed.2026.103535 [doi] PST - aheadofprint SO - Arch Med Res. 2026 Oct 27;58(1):103535. doi: 10.1016/j.arcmed.2026.103535. PMID- 42945744 OWN - NLM STAT- Publisher LR - 20261027 IS - 1879-0267 (Electronic) IS - 0020-1383 (Linking) VI - 57 IP - 12 DP - 2026 Oct 24 TI - The downside of the pull-up: A 10-year national analysis of emergency department visits, 2015-2024. PG - 113804 LID - S0020-1383(26)00791-6 [pii] LID - 10.1016/j.injury.2026.113804 [doi] AB - BACKGROUND: To characterize the epidemiology and clinical patterns of injuries related to pull-up and chin-up bars in a nationally representative emergency department (ED) dataset. METHODS: Retrospective cross-sectional analysis of the U.S. Consumer Product Safety Commission National Electronic Injury Surveillance System from January 1, 2015, to December 31, 2024. Cases were identified using product code 3277 with narrative filters for "pull-up," "chin-up," and "doorway bar," excluding barbells and playground equipment. NEISS sampling weights produced national estimates. Annual totals with 95 % confidence intervals were calculated and reported. Injury characteristics were summarized by age group, body region, diagnosis, location, disposition, and a narrative-derived mechanism category (fall, struck by bar, slip or detachment, other). RESULTS: An estimated 40,987 ED visits were attributed to pull-up bar injuries, averaging about 4000 per year, with a peak in 2024 (5421; 95 % CI, 5315-5527). Patients were predominantly male (66.1 %) with a bimodal age distribution centered on children 5-14 years and adults 18-34 years. Craniofacial trauma predominated, with head and face together comprising nearly one-half of presentations, followed by upper-extremity involvement, including shoulder, wrist, and forearm. Laceration, internal head injury, and fracture were the leading diagnoses, with sprain or strain and contusion also frequent. Most incidents occurred in the home, and 93.8 % of patients were treated and released. Falls were the most common mechanism, followed by struck-by events and a subset explicitly involving bar slip or detachment. CONCLUSIONS: Pull-up bar injuries constitute a consistent national burden of craniofacial and upper-extremity trauma concentrated in youth and young adults, largely managed nonoperatively in acute care settings. Improved recognition of exercise-associated injury mechanisms may assist diagnostic accuracy and reduce the burden on emergency and orthopedic services. CI - Copyright (c) 2026 British Trauma Society. Published by Elsevier Ltd. All rights reserved. FAU - Shabbir, Roban AU - Shabbir R AD - Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. Electronic address: roban@temple.edu. FAU - Layton, Brendan AU - Layton B AD - Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. Electronic address: tuj67333@temple.edu. FAU - Kang, Zion AU - Kang Z AD - Lewis Katz School of Medicine at Temple University, Philadelphia, PA, USA. Electronic address: tus57015@temple.edu. FAU - Kim, Brandon AU - Kim B AD - Department of Orthopedic Surgery, Temple University Hospital, Philadelphia, PA, USA. Electronic address: Brandon.Kim@tuhs.temple.edu. FAU - Rehman, Saqib AU - Rehman S AD - Department of Orthopedic Surgery, Temple University Hospital, Philadelphia, PA, USA. Electronic address: Saqib.Rehman@tuhs.temple.edu. FAU - Galos, David K AU - Galos DK AD - Department of Orthopedic Surgery, Temple University Hospital, Philadelphia, PA, USA. Electronic address: David.Galos@tuhs.temple.edu. LA - eng PT - Journal Article DEP - 20261024 PL - Netherlands TA - Injury JT - Injury JID - 0226040 SB - IM OTO - NOTNLM OT - Craniofacial trauma OT - Emergency department surveillance OT - Exercise-related injuries OT - Home fitness equipment COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/27 23:28 MHDA- 2026/10/27 23:28 CRDT- 2026/10/27 19:06 PHST- 2025/11/18 00:00 [received] PHST- 2026/10/11 00:00 [accepted] PHST- 2026/10/27 23:28 [medline] PHST- 2026/10/27 23:28 [pubmed] PHST- 2026/10/27 19:06 [entrez] AID - S0020-1383(26)00791-6 [pii] AID - 10.1016/j.injury.2026.113804 [doi] PST - aheadofprint SO - Injury. 2026 Oct 24;57(12):113804. doi: 10.1016/j.injury.2026.113804. PMID- 42945536 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261029 IS - 1665-1731 (Electronic) IS - 1405-9940 (Print) IS - 1665-1731 (Linking) VI - 96 IP - Supl 4 DP - 2026 TI - Inter-American consensus on hypertrophic cardiomyopathy. PG - 1-60 LID - 10.24875/ACM.26000187 [doi] AB - BACKGROUND: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy and poses major diagnostic and therapeutic challenges in Latin America, owing to heterogeneity in resource availability, access to advanced technologies, and the organization of health systems. OBJECTIVES: To develop the first Inter-American Consensus on HCM, in order to standardize the care of these patients tailored to the regional context. METHODS: The Inter-American Society of Cardiology (SIAC) convened a committee of experts from different countries across the Americas. A systematic review of the evidence was performed, followed by the development of recommendations, which were validated using a formal Delphi methodology; consensus was defined as agreement among more than 80% of participants. RESULTS: The consensus provides a comprehensive approach to the evaluation and management of HCM. It covers epidemiology, pathophysiology, multimodality diagnostic tools, genetics and family counseling, phenocopies, pharmacological and invasive treatment, associated complications, sudden cardiac death risk assessment, special populations (pediatric and pregnant patients), physical exercise, and follow-up strategies. In addition, it includes specific recommendations aimed at facilitating the implementation of these across Latin America. CONCLUSIONS: The Inter-American Consensus on HCM provides recommendations for the diagnosis and treatment of this condition. It integrates the best available evidence with regional clinical experience and takes into account the epidemiological, economic, and healthcare characteristics of the region. It constitutes a reference framework for standardizing the care of patients with HCM and their families throughout Latin America. CI - Copyright: (c) 2026 Permanyer. FAU - Parodi, Josefina B AU - Parodi JB AD - Departamento de Cardiologia, Sanatorio Anchorena San Martin, San Martin, Buenos Aires, Argentina. FAU - Scatularo, Cristhian E AU - Scatularo CE AD - Departamento de Cardiologia, Sanatorio de la Trinidad de Palermo, Buenos Aires, Argentina. FAU - Berrios-Barcenas, Enrique A AU - Berrios-Barcenas EA AD - Departamento de Consulta Externa, Instituto Nacional de Cardiologia Ignacio Chavez, Ciudad de Mexico, Mexico. FAU - Leon, Juan D Lopez-Ponce de AU - Leon JDL AD - Departamento de Cardiologia, Fundacion Valle del Lili, Cali, Colombia. FAU - Arenaza, Diego Perez de AU - Arenaza DP AD - Servicio de Cardiologia, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. FAU - Gomez, Luis E AU - Gomez LE AD - Division de Cardiologia, Hospital General de Agudos Juan A. Fernandez, Buenos Aires, Argentina. FAU - Costabel, Juan P AU - Costabel JP AD - Unidad Coronaria, Instituto Cardiovascular de Buenos Aires, Buenos Aires, Argentina. FAU - Fernandes, Fabio AU - Fernandes F AD - Grupo de Cardiomiopatias, Instituto do Coracao (InCor), Sao Paulo, Brasil. FAU - Saldarriaga, Clara AU - Saldarriaga C AD - Clinica CardioVID, Universidad Pontificia Bolivariana, Medellin, Colombia. FAU - Rossel, Victor AU - Rossel V AD - Departamento de Cardiologia, Hospital del Salvador, Santiago de Chile, Chile. FAU - Rochitte, Carlos E AU - Rochitte CE AD - Instituto do Coracao (InCor), Sao Paulo, Brasil. FAU - Stein, Ricardo AU - Stein R AD - Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brasil. FAU - Concepcion-Chacon, Roberto AU - Concepcion-Chacon R AD - Unidad de Insuficiencia Cardiaca, Hospital DIPRECA, Santiago de Chile, Chile. FAU - Parma-Romanelli, Gabriel AU - Parma-Romanelli G AD - Departamento de Cardiologia, Hospital Evangelico, Montevideo, Uruguay. FAU - Gonzalez-Carta, Karina AU - Gonzalez-Carta K AD - Departamento de Cirugia Ortopedica, Mayo Clinic, Rochester, Minnesota, EE.UU. FAU - Blanco-Sobrino, Susana AU - Blanco-Sobrino S AD - Servicio de Cardiologia, Instituto de Clinicas y Urologia Tamanaco, Caracas, Venezuela. FAU - Sierra-Lara-Martinez, Daniel AU - Sierra-Lara-Martinez D AD - Urgencias y Unidad de Cuidados Criticos Coronarios, Instituto Nacional de Cardiologia Ignacio Chavez, Ciudad de Mexico, Mexico. FAU - Leoni, Franco AU - Leoni F AD - Medica Uruguaya (MUCAM), Montevideo, Uruguay. FAU - Jalil, Jorge AU - Jalil J AD - Division de Enfermedades Cardiovasculares, Pontificia Universidad Catolica de Chile, Santiago, Chile. FAU - Delgado, Yamiris AU - Delgado Y AD - Servicio de Cardiologia, Centro Medico Real, Santo Domingo, Republica Dominicana. FAU - Chango, Diego X AU - Chango DX AD - Servicio de Cardiologia, Clinica Santa Ana, Cuenca, Ecuador. FAU - Posada-Martinez, Liliana AU - Posada-Martinez L AD - Departamento de Ecocardiografia, Instituto Nacional de Cardiologia Ignacio Chavez, Ciudad de Mexico, Mexico. FAU - Rodriguez-Amaguay, Landy AU - Rodriguez-Amaguay L AD - Servicio de Imagenes Cardiovasculares, Centro Ecuatoriano de Diagnostico Cardiovascular, Guayaquil, Ecuador. FAU - Guaman-Valdivieso, Carlos AU - Guaman-Valdivieso C AD - Novaclinica Santa Cecilia, Quito, Ecuador. FAU - Rendon-Giraldo, Jairo A AU - Rendon-Giraldo JA AD - Departamento de Cardiologia, Hospital San Vicente Fundacion, Medellin, Colombia. FAU - Arevalos, Victor AU - Arevalos V AD - Departamento de Cardiologia, Hospital Central del Instituto de Prevision Social, Asuncion, Paraguay. FAU - Marquez, Ingrid AU - Marquez I AD - Departamento de Cardiologia, Hospital del Este Dr. Domingo Luciani, Caracas, Venezuela. FAU - Cantora, Florencia B AU - Cantora FB AD - Servicio de Cardiologia, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. FAU - Estofan, Mariano D AU - Estofan MD AD - Sanatorio 9 de Julio, San Miguel de Tucuman, Argentina. FAU - Cardenas-Reyes, Ivonne AU - Cardenas-Reyes I AD - Cardiologia Pediatrica, Health in Code, Valencia, Espana. FAU - Brogger, Noel AU - Brogger N AD - Cardiologia Pediatrica, Health in Code, Valencia, Espana. FAU - Bejarano, Maria C AU - Bejarano MC AD - Centro de Investigaciones Clinicas (CIC), Fundacion Valle del Lili, Cali, Colombia. FAU - Lara-Teran, Joffre AU - Lara-Teran J AD - Servicio de Cardiologia, Hospital Juan Tanca Marengo, Guayaquil, Ecuador. FAU - Vaca-Valverde, Ignacio AU - Vaca-Valverde I AD - Cardiovida, Santa Cruz de la Sierra, Bolivia. FAU - Olivares-Asencio, Carlos AU - Olivares-Asencio C AD - Departamento de Cardiologia, Hospital Hernan Henriquez Aravena, Temuco, Chile. FAU - Cura-Hochbaum, Leandro AU - Cura-Hochbaum L AD - Cardiocentro, Asociacion Espanola, Montevideo, Uruguay. FAU - Morejon-Barragan, Paola A AU - Morejon-Barragan PA AD - Clinica Guayaquil, Guayaquil, Ecuador. FAU - Fava, Agostina M AU - Fava AM AD - Cleveland Clinic, Cleveland, Ohio, EE.UU. FAU - Miranda-Arboleda, Andres F AU - Miranda-Arboleda AF AD - Instituto de Cardiologia, Universidad de Ottawa, Ottawa, Canada. FAU - Marquez-Murillo, Manlio F AU - Marquez-Murillo MF AD - Departamento de Cardiologia, Centro Medico ABC, Ciudad de Mexico, Mexico. FAU - Karabut, Eric AU - Karabut E AD - Departamento de Cardiologia, Hospital Punta Pacifica, Ciudad de Panama, Panama. FAU - Berni-Betancourt, Ana C AU - Berni-Betancourt AC AD - Departamento de Cardiologia, Hospital Angeles Pedregal, Ciudad de Mexico, Mexico. FAU - Alba, Ana C AU - Alba AC AD - Peter Munk Cardiac Centre, University Health Network, Toronto, Canada. FAU - Rodriguez-Gonzalez, Maria J AU - Rodriguez-Gonzalez MJ AD - Fundacion Cardioinfantil, Bogota, Colombia. FAU - Saenz-Tejeira, Maria M AU - Saenz-Tejeira MM AD - Servicio de Cardiologia Pediatrica, Hospital Italiano de Buenos Aires, Buenos Aires, Argentina. FAU - Oca, Katihurca Almonte-Montes de AU - Oca KA AD - Asociacion Instituto Dominicano de Cardiologia, Santo Domingo, Republica Dominicana. FAU - Cueto, Rosa N AU - Cueto RN AD - Departamento de Cardiologia, Hospital Regional Dr. Antonio Musa, San Pedro de Macoris, Republica Dominicana. FAU - Rodriguez-Israel, Melissa AU - Rodriguez-Israel M AD - Departamento de Cardiologia, Hospital San Vicente de Paul, Heredia, Costa Rica. FAU - Torterolo-Herrera, Alicia G AU - Torterolo-Herrera AG AD - Departamento de Cardiologia, Hospital de Clinicas, Montevideo, Uruguay. FAU - Villacreses, Vicente AU - Villacreses V AD - Departamento de Cardiologia, Manahospital, Portoviejo, Ecuador. FAU - Restrepo, Gustavo AU - Restrepo G AD - Clinica ANUA Las Americas, Medellin, Colombia. FAU - Sosa-Liprandi, Maria I AU - Sosa-Liprandi MI AD - Departamento de Cardiologia, Sanatorio Guemes, Buenos Aires, Argentina. FAU - Cingolani, Eugenio AU - Cingolani E AD - Departamento de Cardiologia, Centro Medico Cedars-Sinai, Universidad de California, Los Angeles, California, EE.UU. FAU - Baratta, Sergio AU - Baratta S AD - Servicio de Cardiologia, Hospital Universitario Austral, Buenos Aires, Argentina. FAU - Lopez-Santi, Ricardo AU - Lopez-Santi R AD - Departamento de Cardiologia, Hospital Italiano de La Plata, La Plata, Argentina. FAU - Munera-Echeverri, Ana AU - Munera-Echeverri A AD - Departamento de Cardiologia, Clinica Rosario Tesoro-Cardioestudio, Medellin, Colombia. FAU - Baranchuk, Adrian AU - Baranchuk A AD - Facultad de Medicina, Universidad Abierta Interamericana (UAI), Buenos Aires, Argentina. LA - eng PT - Consensus Statement PT - Journal Article PT - Systematic Review TT - Consenso interamericano de miocardiopatia hipertrofica. PL - Mexico TA - Arch Cardiol Mex JT - Archivos de cardiologia de Mexico JID - 101126728 SB - IM MH - Humans MH - *Cardiomyopathy, Hypertrophic/therapy/diagnosis/physiopathology/epidemiology MH - Latin America PMC - PMC13713040 OTO - NOTNLM OT - America Latina OT - Cardiac myosin inhibitors OT - Consenso OT - Consensus OT - Genetic testing OT - Hypertrophic cardiomyopathy OT - Inhibidores de la miosina cardiaca OT - Latin America OT - Miocardiopatia hipertrofica OT - Muerte subita cardiaca OT - Pruebas geneticas OT - Sudden cardiac death COIS- Los autores declaran no tener conflictos de intereses relacionados con el contenido de este manuscrito. EDAT- 2026/10/27 23:28 MHDA- 2026/10/27 23:29 PMCR- 2026/01/01 CRDT- 2026/10/27 17:13 PHST- 2026/10/27 23:29 [medline] PHST- 2026/10/27 23:28 [pubmed] PHST- 2026/10/27 17:13 [entrez] PHST- 2026/01/01 00:00 [pmc-release] AID - j96/Supl 4/1 [pii] AID - 12352AMEX261-ACM-96-1 [pii] AID - 10.24875/ACM.26000187 [doi] PST - ppublish SO - Arch Cardiol Mex. 2026;96(Supl 4):1-60. doi: 10.24875/ACM.26000187. PMID- 42945193 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261029 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 10 DP - 2026 TI - Bridging the gap: Implementing BRIDGES (Brussels Resilience and Inclusion for Depression - Guidance, Exercise and Support) to shape adolescent outpatient mental health care. A pilot randomized controlled study protocol. PG - e0360292 LID - 10.1371/journal.pone.0360292 [doi] LID - e0360292 AB - INTRODUCTION: Physical activity interventions for adolescents with depression often show limited effectiveness due to insufficient developmental tailoring, limited autonomy support, and poor contextual feasibility. BRIDGES (Brussels Resilience and Inclusion for Depression - Guidance, Exercise, and Support) is a theory-informed and co-designed physical activity intervention integrating the COM-B model, self-determination theory and motivational interviewing to support autonomous and competence-enhancing engagement. This pilot randomized controlled trial uses a hybrid type 2 implementation-effectiveness design to examine feasibility, acceptability, implementation processes and obtain preliminary estimates of clinical effectiveness to inform a future larger-scale trial. METHODS AND ANALYSIS: Sixty physically inactive adolescents aged 12-19 years with depression will be recruited from an outpatient mental health service in Brussels, Belgium. Participants will be randomized in waves using covariate-adaptive minimization with a biased-coin component (p=0.85), balancing baseline depression severity, physical activity level, gender and age. The intervention consists of 18 individualized physiotherapist-led counselling sessions delivered over 12 weeks, including structured support to facilitate transition to community-based physical activity. Primary feasibility, acceptability, implementation outcomes will be assessed using quantitative measures and semi-structured interviews with adolescents, caregivers and community partners, guided by the Practical, Robust Implementation and Sustainability Model (PRISM) and the Reach, Effectiveness, Adoption, Implementation and Maintenance (RE-AIM) framework. Preliminary effectiveness outcomes are changes in physical activity measured using the Physical Activity Vital Sign (PAVS) and depressive symptoms measured using the Patient Health Questionnaire-9 modified for Adolescents (PHQ-A). Preliminary effectiveness will be analysed using linear mixed-effects models following an intention-to-treat approach to estimate cluster-level parameters for a future fully powered Hybrid Type 2 trial. Secondary outcomes include social support, exercise self-efficacy, cardiorespiratory fitness and waist-to-height ratio. Qualitative data will be analysed using the Qualitative Analysis Guide of Leuven. TRIAL REGISTRATION: ClinicalTrials.gov NCT07422909. CI - Copyright: (c) 2026 Philippot et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Philippot, Arnaud AU - Philippot A AUID- ORCID: 0000-0002-0706-4491 AD - Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium. AD - AREA+, Psychiatric Units for Adolescents, Epsylon ASBL Psychiatric Network, Brussels, Belgium. AD - UCLouvain, Louvain-la-Neuve, Institute of Neuroscience, Belgium. FAU - Ibanez, Irene AU - Ibanez I AD - AREA+, Psychiatric Units for Adolescents, Epsylon ASBL Psychiatric Network, Brussels, Belgium. FAU - Coppens, Marine AU - Coppens M AD - UCLouvain, Louvain-la-Neuve, Institute of Neuroscience, Belgium. FAU - Eeckhout, Coralie AU - Eeckhout C AD - UCLouvain, Louvain-la-Neuve, Institute of Neuroscience, Belgium. FAU - Cescutti, Catherine AU - Cescutti C AD - AREA+, Psychiatric Units for Adolescents, Epsylon ASBL Psychiatric Network, Brussels, Belgium. FAU - Beine, Alexandre AU - Beine A AD - AREA+, Psychiatric Units for Adolescents, Epsylon ASBL Psychiatric Network, Brussels, Belgium. FAU - Meers, Esther AU - Meers E AUID- ORCID: 0009-0004-0626-6317 AD - Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium. FAU - Van Damme, Tine AU - Van Damme T AD - Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium. AD - University Psychiatric Center KU Leuven, Leuven, Belgium. FAU - Francaux, Marc AU - Francaux M AD - UCLouvain, Louvain-la-Neuve, Institute of Neuroscience, Belgium. FAU - Dubois, Vincent AU - Dubois V AD - AREA+, Psychiatric Units for Adolescents, Epsylon ASBL Psychiatric Network, Brussels, Belgium. AD - UCLouvain, Bruxelles-Woluwe, Institute Health and Society, Belgium. FAU - Vancampfort, Davy AU - Vancampfort D AUID- ORCID: 0000-0002-4592-8625 AD - Department of Rehabilitation Sciences, KU Leuven, Leuven, Belgium. AD - University Psychiatric Center KU Leuven, Leuven, Belgium. AD - Leuven Brain Institute, Leuven, Belgium. LA - eng SI - ClinicalTrials.gov/NCT07422909 PT - Journal Article PT - Randomized Controlled Trial DEP - 20261027 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adolescent MH - Pilot Projects MH - Female MH - Child MH - Male MH - *Depression/therapy/psychology MH - *Exercise MH - Young Adult MH - Outpatients/psychology MH - Belgium MH - Motivational Interviewing MH - *Ambulatory Care MH - *Mental Health Services PMC - PMC13712597 COIS- The authors have declared that no competing interests exist. EDAT- 2026/10/27 17:30 MHDA- 2026/10/27 17:31 PMCR- 2026/10/27 CRDT- 2026/10/27 13:34 PHST- 2026/09/14 00:00 [received] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/10/27 17:31 [medline] PHST- 2026/10/27 17:30 [pubmed] PHST- 2026/10/27 13:34 [entrez] PHST- 2026/10/27 00:00 [pmc-release] AID - PONE-D-26-34598 [pii] AID - 10.1371/journal.pone.0360292 [doi] PST - epublish SO - PLoS One. 2026 Oct 27;21(10):e0360292. doi: 10.1371/journal.pone.0360292. eCollection 2026. PMID- 42945149 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261029 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Oct 27 TI - Refining a Multicomponent Family-Based Health Education Package to Reduce Screen Time Among School-Aged Children: Qualitative Formative Evaluation With Parents and Caregivers. PG - e106521 LID - 10.2196/106521 [doi] LID - e106521 AB - BACKGROUND: Excessive screen time among school-aged children is a growing concern for child health and family routines. A previous systematic review of children aged 6 to 14 years found that excessive screen time is common in this age group, highlighting the need for feasible intervention strategies that can be implemented in daily family routines. Although many health education materials communicate the harms of excessive screen use, families often need practical support to translate risk messages into household rules, parent-child communication, alternative activities, and changes to the home environment. OBJECTIVE: This study aimed to conduct a qualitative formative evaluation of a preliminary multicomponent family-based health education package designed to support healthier screen-use practices among school-aged children, with a primary focus on reducing excessive recreational screen time and associated family routines, and to identify refinements needed before pilot implementation. METHODS: Semistructured online video interviews were conducted with 10 parents or primary caregivers of school-aged children aged 6 to 12 years from October to December 2024. The package included caregiver education for parents and grandparents, child-facing materials such as a picture book and posters, home-use reminder cues, and home-environment guidance through an online self-assessment tool that generated tailored household action suggestions. The tasks assigned to the tool were limited to these functions. Participants reviewed the package components and commented on clarity, acceptability, perceived usefulness, feasibility, fit with family routines, and suggestions for refinement. Data were analyzed using directed content analysis and thematic analysis, informed by the Theoretical Framework of Acceptability (TFA) and health communication material-evaluation dimensions. RESULTS: Four themes were generated. First, the package was generally regarded as acceptable to the participating caregivers, but comprehension did not always translate into self-reported immediate recall during interviews. Second, concrete, scenario-based messages were described as more meaningful than abstract risk information. Third, caregivers wanted action guidance rather than additional risk information. Fourth, caregivers preferred practical, age-adapted, and home-embedded tools that could be repeatedly encountered in daily routines. CONCLUSIONS: Among this selected group of caregivers, the preliminary multicomponent family-based screen-time education package was generally perceived as understandable and acceptable, but participant-informed refinements are needed before pilot implementation. The findings suggest that the package should move beyond general risk communication toward a family action toolkit that combines caregiver guidance, child-facing materials, concrete consequence chains, parent-child negotiation supports, replacement activity lists, and home environmental cues. CI - (c) Mo Zhou, Yujie Yan, Siwei Sun, Hui Yin. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Zhou, Mo AU - Zhou M AUID- ORCID: 0009-0009-1516-3631 AD - The Second People's Hospital of Shenzhen and First Affiliated Hospital of Shenzhen University, Shenzhen, China. FAU - Yan, Yujie AU - Yan Y AUID- ORCID: 0000-0002-8749-268X AD - China Japan Friendship Hospital, Beijing, China. AD - Peking University China-Japan Friendship School of Clinical Medicine, Beijing, China. FAU - Sun, Siwei AU - Sun S AUID- ORCID: 0009-0008-4107-8177 AD - Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China. FAU - Yin, Hui AU - Yin H AUID- ORCID: 0000-0003-4013-1331 AD - School of Public Health, Peking University, No. 38 Xueyuan Road, Haidian District, Beijing, 100191, China, 86 1082805853. AD - Institute for Global Health, Peking University, Beijing, China. LA - eng PT - Journal Article DEP - 20261027 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Qualitative Research MH - *Screen Time MH - *Health Education/methods/standards MH - *Parents/education/psychology MH - *Caregivers/education/psychology MH - Adult MH - Parent-Child Relations PMC - PMC13712257 OTO - NOTNLM OT - caregivers OT - digital media OT - family-based intervention OT - formative evaluation OT - health education OT - qualitative research OT - school-aged children OT - screen time EDAT- 2026/10/27 17:30 MHDA- 2026/10/27 17:31 PMCR- 2026/10/27 CRDT- 2026/10/27 13:14 PHST- 2026/07/08 00:00 [received] PHST- 2026/08/31 00:00 [revised] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/10/27 17:31 [medline] PHST- 2026/10/27 17:30 [pubmed] PHST- 2026/10/27 13:14 [entrez] PHST- 2026/10/27 00:00 [pmc-release] AID - v10i1e106521 [pii] AID - 106521 [pii] AID - 10.2196/106521 [doi] PST - epublish SO - JMIR Form Res. 2026 Oct 27;10:e106521. doi: 10.2196/106521. PMID- 42944973 OWN - NLM STAT- Publisher LR - 20261027 IS - 1179-1926 (Electronic) IS - 0312-5963 (Linking) DP - 2026 Oct 27 TI - Paediatric Fentanyl Population Pharmacokinetics: A Scoping Review of Published Models. LID - 10.1007/s40262-026-01706-5 [doi] AB - OBJECTIVE AND PURPOSE: Fentanyl is a highly lipophilic opioid widely used within paediatric peri-operative and intensive-care settings, yet dosing is commonly titrated empirically because of substantial pharmacokinetic variability across developmental stages and clinical contexts. Population pharmacokinetic (PopPK) models provide a quantitative framework to characterise variability, but these have not been systematically synthesised. This scoping review aimed to identify and summarise published paediatric PopPK models of fentanyl, to compare model structures and covariate effects. METHODS: We searched Embase and MEDLINE databases from database inception to 17 February 2026 for paediatric PopPK models of fentanyl. Two reviewers independently screened papers and extracted data in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. RESULTS: Fourteen paediatric PopPK models of fentanyl were identified. Infants (64%, 9/14) and patient populations spanning multiple age groups (e.g., inclusion of infants and children) (64%, 9/14) were most frequently studied. Intravenous fentanyl was modelled in all studies. Two-compartment structures predominated (79%, 11/14). Body weight was the most consistently retained covariate (79%, 11/14), while maturation functions based on postnatal or postmenstrual age were frequently required in neonatal and infant cohorts (50%, 5/10). Other covariates (e.g., obesity, concomitant CYP3A modulators, and genetic factors) were variably explored and inconsistently retained. CONCLUSION: Within the existing fentanyl literature, important evidence gaps remain, particularly beyond intravenous administration. Existing models highlight body weight and developmental maturation as principal determinants of clearance and distribution. Evidence remains limited to intravenous administration, with no model data of non-intravenous routes and under-representation of dynamic covariates and external validation. Addressing these gaps will support robust model-informed precision dosing of fentanyl in children. CI - (c) 2026. The Author(s). FAU - Hughes, Josephine J AU - Hughes JJ AUID- ORCID: 0009-0008-4715-7597 AD - School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, A15 Pharmacy and Bank Building, Science Road, Camperdown, NSW, 2006, Australia. FAU - Nam, Gi Kon AU - Nam GK AUID- ORCID: 0009-0001-5017-2869 AD - School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, A15 Pharmacy and Bank Building, Science Road, Camperdown, NSW, 2006, Australia. FAU - Stokes, Michael A AU - Stokes MA AUID- ORCID: 0009-0005-6615-4998 AD - School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, A15 Pharmacy and Bank Building, Science Road, Camperdown, NSW, 2006, Australia. AD - Kids Critical Care Research, Children's Hospital at Westmead, Westmead, NSW, Australia. FAU - Sandaradura, Indy AU - Sandaradura I AUID- ORCID: 0000-0002-9457-8262 AD - Centre for Infectious Diseases and Microbiology, Westmead Hospital, Sydney, NSW, Australia. AD - Faculty of Medicine and Health, Westmead Clinical School, The University of Sydney, Sydney, NSW, Australia. AD - Institute of Clinical Pathology and Medical Research, New South Wales Health Pathology, Westmead Hospital, Sydney, NSW, Australia. FAU - Festa, Marino S AU - Festa MS AUID- ORCID: 0000-0001-6541-7841 AD - Kids Critical Care Research, Children's Hospital at Westmead, Westmead, NSW, Australia. FAU - Stocker, Sophie L AU - Stocker SL AUID- ORCID: 0000-0002-2114-587X AD - School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, A15 Pharmacy and Bank Building, Science Road, Camperdown, NSW, 2006, Australia. sophie.stocker@sydney.edu.au. AD - Department of Clinical Pharmacology and Toxicology, St. Vincent's Hospital Sydney, Sydney, NSW, 2010, Australia. sophie.stocker@sydney.edu.au. AD - St. Vincent's Clinical Campus, Faculty of Medicine, University of New South Wales, Sydney, NSW, 2052, Australia. sophie.stocker@sydney.edu.au. LA - eng PT - Journal Article PT - Review DEP - 20261027 PL - Switzerland TA - Clin Pharmacokinet JT - Clinical pharmacokinetics JID - 7606849 SB - IM COIS- Declarations. Conflicts of interest/competing interests: Sophie Stocker is an Editorial Board member of Clinical Pharmacokinetics and was not involved in the selection of peer reviewers for the manuscript nor any of the subsequent editorial decisions. No other authors declare any other conflicts of interest. Ethics approval: Not applicable. Consent to participate: Not applicable. Consent for publication: Not applicable. Availability of data and material code: Not applicable. Authors' contributions: JJH, MAS, SLS, MSF, and IS conceived the article and determined the study design. JJH, GKN, MAS, and SLS participated in article screening and collected the data. JJH drafted the manuscript and analysed the results. All authors contributed to critical review of the manuscript draft and approved the final version of the manuscript. EDAT- 2026/10/27 17:30 MHDA- 2026/10/27 17:30 CRDT- 2026/10/27 12:20 PHST- 2026/05/01 00:00 [received] PHST- 2026/09/01 00:00 [accepted] PHST- 2026/10/27 17:30 [medline] PHST- 2026/10/27 17:30 [pubmed] PHST- 2026/10/27 12:20 [entrez] AID - 10.1007/s40262-026-01706-5 [pii] AID - 10.1007/s40262-026-01706-5 [doi] PST - aheadofprint SO - Clin Pharmacokinet. 2026 Oct 27. doi: 10.1007/s40262-026-01706-5. PMID- 42942963 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261029 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 20 DP - 2026 Oct 16 TI - The Preterm Brain Is Also What It Eats: A Systematic Review of Nutrition and Neuroimaging Outcomes in Preterm Infants. LID - 10.3390/nu18203392 [doi] LID - 3392 AB - Background: Nutrition is one of the most modifiable determinants of brain development in preterm infants. Although increasing evidence supports associations between early nutritional exposures and neurodevelopment, studies remain heterogeneous regarding nutritional interventions, imaging biomarkers, and long-term outcomes. This systematic review aimed to summarize contemporary evidence on the relationship between nutrition and brain development in preterm infants using neuroimaging as the primary assessment tool while proposing an integrated translational framework to guide future research. Methods: Following a PECO framework, a systematic literature search was conducted in PubMed, Scopus, and CINAHL: population, infants born before 37 completed weeks of gestation; exposure, any enteral or parenteral nutritional exposure, supplementation strategy, fortification approach, or individualized nutritional intervention; comparator, an alternative nutritional strategy, lower or absent exposure, standard care or, when relevant, a term-born reference group; outcomes, MRI- or CUS-based measures of brain growth, maturation, connectivity, or injury. Studies reporting volumetric, morphometric, diffusion, connectivity, spectroscopy, or quantitative ultrasound outcomes were eligible. The methodology was adapted from the PROSPERO-registered review by Ottolini et al. Original studies published between 2020 and 2026 (1 January 2020-4 September 2026) evaluating nutritional exposures or interventions in preterm infants with magnetic resonance imaging (MRI) and/or cranial ultrasound (CUS) outcomes were included. Risk of bias was assessed using the Newcastle-Ottawa Scale (NOS), ROBINS-I and RoB 2 according to study design. Quantitative imaging studies were screened for eligibility for ATLAS assessment. Given the substantial heterogeneity in nutritional exposures, imaging protocols, timing of assessments, and neurodevelopmental outcomes, meta-analysis was not performed. Certainty of evidence was assessed at the level of each causal question and neuroimaging outcome domain using the GRADE framework. Randomized intervention evidence and observational exposure evidence were evaluated according to the design and target contrast contributing to each body of evidence. Judgments considered risk of bias, inconsistency, indirectness, imprecision, publication bias, and, where applicable, factors that could increase certainty. Statistical significance was not used to determine certainty, and studies arising from shared or partially overlapping parent populations were not counted as independent replication. Results: We found 33 reports that met the inclusion criteria: 4 evaluated randomized treatment contrasts, 5 non-randomized intervention comparisons, and 24 observational nutritional exposure analyses. Greater exposure to human milk and selected strategies involving early protein and lipid provision, docosahexaenoic acid, omega-3 fatty acids, and individualized nutritional support were associated in several studies with favorable MRI measurements, including larger total or regional brain volumes, more advanced white-matter maturation, and differences in structural or functional connectivity. Some studies also reported associations with later neurodevelopment. However, findings were not uniform, and GRADE certainty across outcome-specific nutrition-neuroimaging questions ranged from very low to low, principally because of risk of bias, imprecision, heterogeneous exposure and imaging definitions, and limited independent replication. Although causal inference cannot be directly drawn, neuroimaging may provide quantitative measures of brain development that can be investigated alongside long-term neurodevelopmental outcomes. We propose the Roadmap for Imaging-Guided Enhancement of Neurodevelopment (RIGEL), an integrative research framework combining imaging, molecular biomarkers, standardized neurodevelopmental assessment, and epidemiological evidence across developmental stages. RIGEL should be regarded as a hypothesis-generating research framework that requires prospective validation before any clinical implementation. FAU - Canepa, Maria Ester AU - Canepa ME AUID- ORCID: 0009-0004-7400-1724 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Mother-Child Health, University of Genoa, 16132 Genoa, Italy. FAU - Prefumo, Federico AU - Prefumo F AUID- ORCID: 0000-0001-7793-714X AD - Obstetrics and Gynecology Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy. FAU - Biagioli, Valentina AU - Biagioli V AUID- ORCID: 0009-0004-3021-6627 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Mother-Child Health, University of Genoa, 16132 Genoa, Italy. FAU - Striano, Pasquale AU - Striano P AUID- ORCID: 0000-0002-6065-1476 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Mother-Child Health, University of Genoa, 16132 Genoa, Italy. AD - Pediatric Neurology and Muscular Diseases Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy. FAU - Calandrino, Andrea AU - Calandrino A AUID- ORCID: 0000-0002-2710-1798 AD - Neonatal Intensive Care Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy. FAU - Ramenghi, Luca Antonio AU - Ramenghi LA AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Mother-Child Health, University of Genoa, 16132 Genoa, Italy. AD - Neonatal Intensive Care Unit, IRCCS Istituto Giannina Gaslini, 16147 Genoa, Italy. LA - eng PT - Journal Article PT - Review PT - Systematic Review DEP - 20261016 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Female MH - Humans MH - Infant, Newborn MH - *Brain/growth & development/diagnostic imaging MH - *Infant Nutritional Physiological Phenomena MH - *Infant, Premature/growth & development MH - Magnetic Resonance Imaging MH - *Neurodevelopment MH - *Neuroimaging MH - *Nutritional Status PMC - PMC13708710 OTO - NOTNLM OT - MRI OT - brain OT - development OT - growth OT - imaging OT - neonate OT - nutrition COIS- The authors declare no conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 22:05 PMCR- 2026/10/16 CRDT- 2026/10/27 10:43 PHST- 2026/08/06 00:00 [received] PHST- 2026/09/12 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/27 22:05 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:43 [entrez] PHST- 2026/10/16 00:00 [pmc-release] AID - nu18203392 [pii] AID - nutrients-18-03392 [pii] AID - 10.3390/nu18203392 [doi] PST - epublish SO - Nutrients. 2026 Oct 16;18(20):3392. doi: 10.3390/nu18203392. PMID- 42942926 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261028 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 20 DP - 2026 Oct 13 TI - School-Based Rescued Produce Distribution, and Changes in Parental Fruit Intake and Household Dietary Behaviors: A Non-Randomized Controlled Cluster Trial. LID - 10.3390/nu18203355 [doi] LID - 3355 AB - Background/Objectives: Fruit and vegetable intake remains below recommended levels, particularly among families facing socioeconomic constraints. School-based food access interventions may improve household dietary behaviors. This study evaluated the association between participation in the "Leket Health" school-based rescued produce distribution program and changes in parental fruit and vegetable intake, nutrition-related parenting practices, and household food security. Children's fruit and vegetables intake was assessed as a secondary exploratory outcome. Methods: A non-randomized controlled cluster trial was conducted among parents (n = 281) of 4th-5th-grade students at three elementary schools in a peripheral town in Israel, with one school per study arm (three clusters in total). Schools were assigned to full intervention (biweekly fruit and vegetable boxes and nutrition education), partial intervention (boxes only), or control. Parent data were collected at baseline and after 7 months using both self-reported fruit and vegetable portions and a validated food frequency questionnaire (FFQ), food security questionnaire, and parental behavior questionnaire. Child intake was assessed using a study-specific FFQ. Primary analyses used a complete-case approach, supplemented by an allocation-based multiple-imputation sensitivity analysis among 269 identifiable participants. The trial was not registered in a public registry. Results: A total of 70% of enrolled participants completed the study. The two parental intake measures yielded discordant findings: categorical changes in parent-reported daily fruit servings differed across study groups in the complete-case analysis (p = 0.028), whereas FFQ-derived fruit and vegetable intake (g/day) showed no statistically significant between-group differences. The overall parenting-practices score showed no statistically significant change (p = 0.770) or between-group difference (p = 0.297). Household food insecurity increased from 8.7% to 14.3% and worsened across all study arms, with no significant between-group difference in deterioration (p = 0.810). No primary dietary endpoint was prespecified. In the allocation-based multiple-imputation analysis, adjusted follow-up fruit intake was higher than control by 0.38 portions/day (95% CI 0.04-0.71) in the full-intervention arm and 0.25 portions/day (95% CI -0.10 to 0.61) in the partial-intervention arm; estimates were attenuated under more adverse assumptions regarding missing outcomes. In an exploratory post-allocation adherence analysis, each additional produce box collected was associated with 6.7% higher odds of a parent-reported increase in fruit intake (OR = 1.067, 95% CI 1.003-1.135; p = 0.040). Among intervention participants, parent-reported improvements in nutrition-related parenting practices were associated with parent-reported increases in household vegetable variety (OR = 2.219, 95% CI 1.057-4.656; p = 0.035). These exploratory associations do not establish intervention effects. The overall parenting-practices score showed no statistically significant change (p = 0.770) or between-group difference (p = 0.297). Household food insecurity increased from 8.7% to 14.3% and worsened across all study arms, with no significant between-group difference in deterioration (p = 0.810). Among children, no significant changes were observed in FFQ-derived intake. Conclusions: Program participation was associated with higher parent-reported fruit servings, although the magnitude of between-arm differences varied across missing-data assumptions. No significant changes were observed in parental vegetable servings or FFQ-derived fruit and vegetable intake among parents or children. Given the single-school-per-arm design, these findings should be interpreted as exploratory and require confirmation in studies with multiple schools per arm. FAU - Hod-Ovadia, Smadar AU - Hod-Ovadia S AD - Department of Nutrition Sciences, Faculty of Health Sciences, Ariel University, Ariel 40700, Israel. AD - Leket Israel, Ra'anana 43650, Israel. FAU - Kilzi, Moran AU - Kilzi M AD - Department of Nutrition Sciences, Faculty of Health Sciences, Ariel University, Ariel 40700, Israel. AD - Leket Israel, Ra'anana 43650, Israel. FAU - Factor, Hagai AU - Factor H AD - Department of Psychology, Faculty of Humanities and Social Sciences, Ariel University, Ariel 40700, Israel. FAU - Boaz, Mona AU - Boaz M AUID- ORCID: 0000-0002-3920-7549 AD - Department of Nutrition Sciences, Faculty of Health Sciences, Ariel University, Ariel 40700, Israel. FAU - Kaufman-Shriqui, Vered AU - Kaufman-Shriqui V AUID- ORCID: 0000-0003-3190-4187 AD - Department of Nutrition Sciences, Faculty of Health Sciences, Ariel University, Ariel 40700, Israel. AD - The Center for Urban Health Solutions (C-UHS), St. Michael's Hospital, Toronto, ON M5B 1T8, Canada. LA - eng GR - Leket Israel/ GR - Ariel University/ PT - Journal Article DEP - 20261013 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Fruit MH - *Vegetables MH - Male MH - Female MH - Child MH - *Parents MH - *Feeding Behavior MH - Schools MH - Israel MH - Parenting MH - *Diet MH - Family Characteristics MH - *School Health Services MH - Food Supply MH - Food Security PMC - PMC13708734 OTO - NOTNLM OT - food rescue OT - food security OT - fruit and vegetable intake OT - nutrition education OT - nutrition equity OT - parental dietary behavior OT - produce distribution OT - school-based intervention COIS- Leket Israel funded the study and implemented the Leket Health intervention program. S.H.-O. and M.K. are employed by Leket Israel, the organization that operates the Leket Health program. This employment is disclosed as a competing interest. To support research independence, data were collected using structured questionnaires, and statistical analyses were conducted by an external statistician using de-identified data. The authors declare no other conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 22:05 PMCR- 2026/10/13 CRDT- 2026/10/27 10:43 PHST- 2026/09/02 00:00 [received] PHST- 2026/10/07 00:00 [revised] PHST- 2026/10/09 00:00 [accepted] PHST- 2026/10/27 22:05 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:43 [entrez] PHST- 2026/10/13 00:00 [pmc-release] AID - nu18203355 [pii] AID - nutrients-18-03355 [pii] AID - 10.3390/nu18203355 [doi] PST - epublish SO - Nutrients. 2026 Oct 13;18(20):3355. doi: 10.3390/nu18203355. PMID- 42942917 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261028 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 20 DP - 2026 Oct 13 TI - Social Dynamics Are Associated with Plant-Based Dietary Consumption Patterns Among Rural Adults in the U.S. LID - 10.3390/nu18203346 [doi] LID - 3346 AB - BACKGROUND/OBJECTIVES: Social dynamics are known to influence eating behaviors and differ across geographic contexts. Some evidence suggests healthy plant-based diets (PBDs) are associated with reduced risk of chronic diseases, morbidity and mortality, and have lower environmental burdens. This paper examines the role of social influence, expectations, and pressures in consumption of PBDs among rural residents in the United States, with attention to gender differences. METHODS: National survey data from rural adults (n = 2210) were analyzed using adjusted logistic regression models including an interaction between social beliefs and gender, and qualitative interviews (n = 55) thematically explored gendered social influences on PBD patterns. RESULTS: Results showed that perceived expectations from important members of the respondents' social network were positively associated with PBD adherence (p < 0.001), without a significant overall interaction with gender (p = 0.163). Perceived social pressure was also associated with PBD adherence overall (p = 0.009), and the association differed by gender (interaction p = 0.001), but did not show a consistent trend across levels of agreement. Qualitative findings suggested that family members influenced the feasibility of PBD, while friends were more commonly described as supportive. Women appeared to face challenges to enacting a PBD when family members (especially male partners) were not supportive. CONCLUSIONS: These results suggest social relationships have complex and gendered roles in shaping PBD among rural residents in the United States. FAU - Alvirdizadeh, Sevda AU - Alvirdizadeh S AUID- ORCID: 0000-0002-2178-9448 AD - Food Systems Program, University of Vermont, Burlington, VT 05405, USA. AD - Gund Institute for Environment, University of Vermont, Burlington, VT 05405, USA. FAU - Abdul-Rahaman, Saadatu AU - Abdul-Rahaman S AUID- ORCID: 0009-0003-7241-750X AD - Food Systems Program, University of Vermont, Burlington, VT 05405, USA. AD - Gund Institute for Environment, University of Vermont, Burlington, VT 05405, USA. FAU - Seguin-Fowler, Rebecca A AU - Seguin-Fowler RA AUID- ORCID: 0000-0002-5115-2341 AD - Institute for Advancing Health Through Agriculture, Texas A&M AgriLife Research, College Station, TX 77843, USA. AD - Department of Nutrition, College of Agriculture and Life Sciences, Texas A&M University, College Station, TX 77843, USA. FAU - Belarmino, Emily H AU - Belarmino EH AUID- ORCID: 0000-0002-5505-1214 AD - Food Systems Program, University of Vermont, Burlington, VT 05405, USA. AD - Gund Institute for Environment, University of Vermont, Burlington, VT 05405, USA. AD - Department of Nutrition and Food Sciences, University of Vermont, Burlington, VT 05405, USA. LA - eng GR - Hatch project 1025975/National Institute of Food and Agriculture/ PT - Journal Article DEP - 20261013 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Male MH - United States MH - *Rural Population/statistics & numerical data MH - Adult MH - Middle Aged MH - *Diet, Plant-Based MH - Aged MH - *Feeding Behavior MH - Sex Factors MH - Social Group MH - Young Adult MH - Social Support MH - Adolescent MH - *Diet, Healthy/psychology PMC - PMC13708334 OTO - NOTNLM OT - food systems OT - plant-based diet OT - rural America OT - social norms COIS- RASF is owner and director of strongpeopleprogram.org. No other authors have COIs to declare. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 22:05 PMCR- 2026/10/13 CRDT- 2026/10/27 10:43 PHST- 2026/09/02 00:00 [received] PHST- 2026/10/02 00:00 [revised] PHST- 2026/10/06 00:00 [accepted] PHST- 2026/10/27 22:05 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:43 [entrez] PHST- 2026/10/13 00:00 [pmc-release] AID - nu18203346 [pii] AID - nutrients-18-03346 [pii] AID - 10.3390/nu18203346 [doi] PST - epublish SO - Nutrients. 2026 Oct 13;18(20):3346. doi: 10.3390/nu18203346. PMID- 42942880 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261028 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 20 DP - 2026 Oct 9 TI - New Vitamin and Mineral Supplements: Acceptability, Tolerability, and Short-Term Adherence in a Paediatric Cohort with IMDs. LID - 10.3390/nu18203309 [doi] LID - 3309 AB - Background/Objectives: Dietary therapy for inherited metabolic disorders (IMDs) can restrict nutrient-dense foods and increase reliance on vitamin and mineral supplementation. However, formulation-related barriers may limit supplement acceptability and adherence, particularly in children with feeding difficulties and complex dietary regimens. We evaluated the acceptability, gastrointestinal (GI) tolerability, and short-term adherence of two novel low-carbohydrate, low-volume vitamin and mineral formulations in children and adolescents with IMDs. Methods: This prospective, single-centre, open-label, non-randomised interventional study enrolled children and adolescents with IMDs aged >/=1 year who were either taking vitamin and mineral supplements already or were clinically identified as requiring micronutrient supplementation. Participants replaced their usual vitamin and mineral supplement with one of two age-appropriate study formulations (product A or B) for 7 consecutive days under usual home conditions. Acceptability was assessed using structured questionnaires, GI symptoms were assessed at baseline and on day 7 and monitored using daily diaries, and adherence was recorded daily by caregivers. Clinical characteristics and anthropometric measurements were assessed at baseline. Results: Thirty-one participants (median age, 7.2 years; range, 2.1-16.6) were enrolled; 15 were allocated to study product A and 16 to study product B, with 14 and 15 participants, respectively, completing the 7-day intervention. Full-dose intake (always or mostly) during the 7-day study period was reported in 27/30 (90.0%) participants. Among evaluable participants, GI symptoms improved or remained unchanged in 12/13 (92.3%) receiving product A and in 12/14 (85.7%) receiving product B. Mean acceptability scores improved for both product A (from 2.4 to 1) and product B (from 2.2 to 0.4), with lower scores indicating greater acceptability. Overall preference for the study product was reported by 10/14 (71.4%) participants receiving product A and 15/15 (100%) receiving product B. At the end of the study, 6/14 (42.9%) participants receiving product A and 7/15 (46.7%) receiving product B elected to continue to use the study product. Conclusions: In this exploratory study, two low-carbohydrate, low-volume vitamin and mineral formulations demonstrated favourable short-term acceptability, GI tolerability, and adherence in children and adolescents with IMDs. These findings suggest that formulation characteristics and ease of administration may influence the practical feasibility of micronutrient supplementation in this population. However, the short seven-day study duration and absence of a control group limit interpretation of these findings. Larger, longer-term studies are warranted to determine whether these benefits are sustained and whether improved acceptability and adherence translate into improved micronutrient status and clinical outcomes. FAU - Tosi, Martina AU - Tosi M AUID- ORCID: 0000-0003-4859-5288 AD - Department of Dietetics, Birmingham Women's and Children's Hospital, Birmingham B4 6NH, UK. FAU - Evans, Sharon AU - Evans S AUID- ORCID: 0000-0002-7654-3621 AD - Department of Dietetics, Birmingham Women's and Children's Hospital, Birmingham B4 6NH, UK. FAU - Yilmaz Nas, Ozlem AU - Yilmaz Nas O AUID- ORCID: 0000-0002-2941-9505 AD - Department of Dietetics, Birmingham Women's and Children's Hospital, Birmingham B4 6NH, UK. FAU - Daly, Anne AU - Daly A AUID- ORCID: 0000-0003-2579-8699 AD - Department of Dietetics, Birmingham Women's and Children's Hospital, Birmingham B4 6NH, UK. FAU - Pinto, Alex AU - Pinto A AD - Department of Dietetics, Birmingham Women's and Children's Hospital, Birmingham B4 6NH, UK. FAU - Ackrill, Julia AU - Ackrill J AD - Department of Dietetics, Birmingham Women's and Children's Hospital, Birmingham B4 6NH, UK. FAU - Ashmore, Catherine AU - Ashmore C AD - Department of Dietetics, Birmingham Women's and Children's Hospital, Birmingham B4 6NH, UK. FAU - MacDonald, Anita AU - MacDonald A AD - Department of Dietetics, Birmingham Women's and Children's Hospital, Birmingham B4 6NH, UK. LA - eng PT - Journal Article DEP - 20261009 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Vitamins) RN - 0 (Minerals) SB - IM MH - Humans MH - Adolescent MH - Child MH - *Dietary Supplements/adverse effects MH - Female MH - Male MH - Child, Preschool MH - *Vitamins/administration & dosage/adverse effects MH - Prospective Studies MH - *Metabolic Diseases/drug therapy MH - *Patient Acceptance of Health Care MH - *Patient Compliance MH - *Minerals/administration & dosage/adverse effects PMC - PMC13708595 OTO - NOTNLM OT - children OT - inherited metabolic disorders OT - micronutrient deficiency OT - mineral supplementation OT - multivitamin OT - palatability OT - product acceptability OT - restricted diet OT - vitamin supplementation COIS- M.T. has received research fundings from Vitaflo International, British Inherited Metabolic Disease Group (BIMDG, Cambridge, UK), National Society for Phenylketonuria UK (NSPKU, Chesterfield, UK) and Galen (Craigavon, UK) and grants from Vitaflo International, Nutricia, PIAM (Genoa, Italy), Applied Pharma Research (Balerna, Switzerland), Galen, PTC Therapeutics (Warren, NJ, USA) and MetaX (Shanghai, China) to attend scientific meetings; S.E. has received research funding from Vitaflo International and Nutricia; O.Y.N. has received research fundings from the Scientific and Technological Research Council of Turkey (TUBITAK), NSPKU, Vitaflo International, and PTC Therapeutics, and grants from BioMarin (San Rafael, CA, USA), Vitaflo International and LogixX Pharma (Reading, UK) to attend scientific meetings; A.D. is an advisory board member Arla (Viby J, Denmark), Vitaflo International and PTC Pharmaceuticals, and has received research funding and honoraria from Nutricia, Vitaflo International, Meta Healthcare (Hemel Hempstead, UK), Galen, Arla, PTC and Metax. A.P. received an educational grant from Cambrooke Therapeutics (Ayer, MA, USA) and Biomarin and grants from Vitaflo International, Nutricia, Biomarin, Mevalia (Burgstall, Italy), Galen, PIAM, Applied Pharma Research, PTC Therapeutics and LogixX Pharma to attend scientific meetings; A.M. is an advisory board member for Arla and receives research funding from Vitaflo International, Nutricia and Metax. J.A. and C.A. declare no conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 22:05 PMCR- 2026/10/09 CRDT- 2026/10/27 10:43 PHST- 2026/09/03 00:00 [received] PHST- 2026/10/04 00:00 [revised] PHST- 2026/10/05 00:00 [accepted] PHST- 2026/10/27 22:05 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:43 [entrez] PHST- 2026/10/09 00:00 [pmc-release] AID - nu18203309 [pii] AID - nutrients-18-03309 [pii] AID - 10.3390/nu18203309 [doi] PST - epublish SO - Nutrients. 2026 Oct 9;18(20):3309. doi: 10.3390/nu18203309. PMID- 42942739 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 1999-4923 (Print) IS - 1999-4923 (Electronic) IS - 1999-4923 (Linking) VI - 18 IP - 10 DP - 2026 Sep 23 TI - Beyond Creatinine: D-Amino Acids as Emerging Indicators of Kidney Function and Disease. LID - 10.3390/pharmaceutics18101207 [doi] LID - 1207 AB - Despite decades of clinical use, serum creatinine and cystatin C remain imperfect indicators of kidney function, being influenced by muscle mass, age, sex, and inflammation and often showing limited sensitivity to early renal injury. D-amino acids (D-AAs), once largely regarded as by-products of microbial metabolism, have emerged as biologically active chiral metabolites with promising potential for improving the assessment of renal function and disease. This review synthesizes current mechanistic, analytical, and clinical evidence on D-AAs in chronic kidney disease, tracing their origins in diet, gut microbiota, and endogenous racemization through their stereoselective renal transport, tubular handling, and urinary excretion. Among these molecules, D-serine and D-asparagine have emerged as particularly promising biomarkers, showing strong associations with measured glomerular filtration rate and, in early studies, performance comparable or superior to conventional markers, though evidence remains limited to small or selected cohorts, while appearing less dependent on body composition across adult and pediatric populations. Beyond their biomarker potential, D-AAs participate in signaling and metabolic processes linking the gut, kidney, and brain, with altered D-AA homeostasis implicated in both renal injury and uremic neurological dysfunction. We critically examine the biological and clinical confounders, analytical challenges, and validation gaps that currently limit their translation into clinical practice and discuss how chiral metabolomics could contribute to a more precise assessment of kidney function and disease. FAU - Uifalean, Alina AU - Uifalean A AUID- ORCID: 0000-0003-1297-6345 AD - Department of Pharmaceutical Analysis, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Louis Pasteur Street 6, 400349 Cluj-Napoca, Romania. FAU - Iacobescu, Maria AU - Iacobescu M AUID- ORCID: 0000-0002-0659-8926 AD - Department of Personalized Medicine and Rare Diseases, MEDFUTURE-Institute for Biomedical Research, "Iuliu Hatieganu" University of Medicine and Pharmacy, Louis Pasteur Street 6, 400349 Cluj-Napoca, Romania. FAU - Muresan, Ximena Maria AU - Muresan XM AD - Department of Personalized Medicine and Rare Diseases, MEDFUTURE-Institute for Biomedical Research, "Iuliu Hatieganu" University of Medicine and Pharmacy, Louis Pasteur Street 6, 400349 Cluj-Napoca, Romania. FAU - Heghes, Simona Codruta AU - Heghes SC AUID- ORCID: 0000-0001-7823-4390 AD - Department of Pharmaceutical Analysis, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Louis Pasteur Street 6, 400349 Cluj-Napoca, Romania. FAU - Salanta, Liana Claudia AU - Salanta LC AUID- ORCID: 0000-0003-2435-405X AD - Department of Food Science, Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, 400372 Cluj-Napoca, Romania. FAU - Moldovan, Radu-Cristian AU - Moldovan RC AUID- ORCID: 0000-0002-2847-1301 AD - Department of Personalized Medicine and Rare Diseases, MEDFUTURE-Institute for Biomedical Research, "Iuliu Hatieganu" University of Medicine and Pharmacy, Louis Pasteur Street 6, 400349 Cluj-Napoca, Romania. FAU - Iuga, Cristina-Adela AU - Iuga CA AUID- ORCID: 0000-0002-0345-0993 AD - Department of Pharmaceutical Analysis, Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Louis Pasteur Street 6, 400349 Cluj-Napoca, Romania. AD - Department of Personalized Medicine and Rare Diseases, MEDFUTURE-Institute for Biomedical Research, "Iuliu Hatieganu" University of Medicine and Pharmacy, Louis Pasteur Street 6, 400349 Cluj-Napoca, Romania. LA - eng GR - 32154/4/16.12.2024/Iuliu Hatieganu University of Medicine and Pharmacy/ PT - Journal Article PT - Review DEP - 20260923 PL - Switzerland TA - Pharmaceutics JT - Pharmaceutics JID - 101534003 PMC - PMC13708084 OTO - NOTNLM OT - D-amino acids OT - D-asparagine OT - D-serine OT - biomarkers OT - chiral metabolomics OT - chronic kidney disease OT - gut-kidney axis COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/09/23 CRDT- 2026/10/27 10:43 PHST- 2026/08/25 00:00 [received] PHST- 2026/09/20 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:43 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - pharmaceutics18101207 [pii] AID - pharmaceutics-18-01207 [pii] AID - 10.3390/pharmaceutics18101207 [doi] PST - epublish SO - Pharmaceutics. 2026 Sep 23;18(10):1207. doi: 10.3390/pharmaceutics18101207. PMID- 42942225 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2075-1729 (Print) IS - 2075-1729 (Electronic) IS - 2075-1729 (Linking) VI - 16 IP - 10 DP - 2026 Sep 30 TI - Foot Posture Outweighs Habitual Footwear in Discriminating Concurrent Lower-Limb Pain in Children: A Cross-Sectional Interpretable Machine-Learning Study. LID - 10.3390/life16101639 [doi] LID - 1639 AB - Lower-limb pain is common in school-aged children, but the relative contributions of foot posture, adiposity, and footwear remain uncertain, and prediction models may be inflated by target leakage. We aimed to quantify how well foot posture, adiposity, and footwear discriminate current lower-limb pain, and whether machine learning outperforms penalised logistic regression. We analysed a cross-sectional school-based dataset of 4408 children aged 4-14 years from Turkiye. Eight classifiers were trained with five-fold cross-validation and evaluated once in a held-out 20% test set; pain-site information was excluded from the primary predictors because it encoded the outcome. Test values of the area under the receiver operating characteristic curve (AUROC) ranged from 0.945 to 0.962; extremely randomised trees (0.961; 95% CI 0.942-0.977) did not outperform penalised logistic regression (DeltaAUROC 0.0003, 95% CI -0.0075 to 0.0095; p = 0.99). Foot posture alone reached an AUROC of 0.909, whereas demographics plus anthropometry reached 0.704, and adding footwear increased this only to 0.723. Therefore, concurrent lower-limb pain was discriminated mainly by foot posture and adiposity, while footwear and algorithmic complexity added little. As posture and pain were recorded concurrently, the models discriminate current rather than future pain. The findings are most relevant to first-contact assessment in general practice. FAU - Buyukcelebi, Hakan AU - Buyukcelebi H AUID- ORCID: 0000-0002-5504-6917 AD - Department of Coaching Education, Faculty of Sport Sciences, Inonu University, Malatya 44000, Turkiye. FAU - Acak, Mahmut AU - Acak M AD - Department of Coaching Education, Faculty of Sport Sciences, Canakkale Onsekiz Mart University, Canakkale 17100, Turkiye. FAU - Eken, Ozgur AU - Eken O AUID- ORCID: 0000-0002-5488-3158 AD - Department of Physical Education and Sport Teaching, Faculty of Sport Sciences, Inonu University, Malatya 44280, Turkiye. FAU - Atalan, Abdulkadir AU - Atalan A AUID- ORCID: 0000-0003-0924-3685 AD - Department of Industrial Engineering, Faculty of Engineering, Canakkale Onsekiz Mart University, Canakkale 17100, Turkiye. FAU - Sanal, Alperen AU - Sanal A AUID- ORCID: 0000-0002-6852-8990 AD - Department of Coaching Education, Faculty of Sport Sciences, Canakkale Onsekiz Mart University, Canakkale 17100, Turkiye. FAU - Yalcin, Ebru AU - Yalcin E AD - Department of Coaching Education, Faculty of Sport Sciences, Canakkale Onsekiz Mart University, Canakkale 17100, Turkiye. FAU - Bakhsh, Hadeel R AU - Bakhsh HR AUID- ORCID: 0000-0002-3000-880X AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. FAU - Aldhahi, Monira I AU - Aldhahi MI AUID- ORCID: 0000-0002-5255-4860 AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. LA - eng GR - PNURSP2026R286/Princess Nourah bint Abdulrahman University/ PT - Journal Article DEP - 20260930 PL - Switzerland TA - Life (Basel) JT - Life (Basel, Switzerland) JID - 101580444 PMC - PMC13706620 OTO - NOTNLM OT - SHAP OT - diagnostic prediction model OT - explainable artificial intelligence OT - flatfoot OT - foot pain OT - foot posture OT - footwear OT - machine learning OT - paediatric lower-limb pain COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analysis, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/09/30 CRDT- 2026/10/27 10:41 PHST- 2026/08/31 00:00 [received] PHST- 2026/09/23 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:41 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - life16101639 [pii] AID - life-16-01639 [pii] AID - 10.3390/life16101639 [doi] PST - epublish SO - Life (Basel). 2026 Sep 30;16(10):1639. doi: 10.3390/life16101639. PMID- 42941262 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2218-1989 (Print) IS - 2218-1989 (Electronic) IS - 2218-1989 (Linking) VI - 16 IP - 10 DP - 2026 Oct 16 TI - Nutrition, T-2 Toxin, and Gut Microbiota in Kashin-Beck Disease: Current Evidence and Proposed Links Within the Microbiota-Gut-Osteochondral Framework. LID - 10.3390/metabo16100787 [doi] LID - 787 AB - Kashin-Beck disease (KBD) is an endemic osteoarthropathy characterized by the degeneration and necrosis of articular cartilage and epiphyseal growth plate cartilage, with disease onset occurring predominantly during childhood. Its etiology has long been associated with environmental and nutritional factors, particularly selenium deficiency, T-2 toxin exposure, and dietary imbalance. Recent studies have also reported alterations in gut microbial composition and metabolic profiles in patients with KBD, raising the possibility that the gut microbiota may represent an additional component of its multifactorial etiology. This narrative review critically evaluates current evidence linking nutritional factors, T-2 toxin exposure, gut microbial alterations, and osteochondral injury in KBD, with particular attention to the level of evidence supporting these relationships. Direct human evidence is currently limited to a small number of predominantly cross-sectional microbiome and metabolomic studies, largely involving adults with established KBD. KBD-related experimental models provide evidence that selenium deficiency and T-2 toxin exposure can induce osteochondral injury, including combined-exposure effects, and experimental studies also indicate that these exposures can be associated with alterations in gut microbial composition. However, these findings do not demonstrate that gut microbial changes mediate exposure-related osteochondral injury. Proposed pathways involving short-chain fatty acids (SCFAs), intestinal-barrier dysfunction, lipopolysaccharide (LPS)-related inflammatory signaling, immune regulation, and bone remodeling are supported mainly by experimental or mechanistic evidence from non-KBD settings and have not been validated as an integrated causal pathway in KBD. The microbiota-gut-osteochondral framework should therefore be regarded as an evidence-stratified, hypothesis-generating model. Prospective studies in children and adolescents from endemic areas, together with factorial exposure models, direct measurement of proposed intermediate mediators, and functional microbiota-manipulation experiments, are needed to determine whether gut microbial alterations contribute causally to KBD development. FAU - Liu, Yang AU - Liu Y AD - Department of Occupational and Environmental Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. AD - Collaborative Innovation Center of Endemic Disease and Health Promotion for Silk Road Region, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. FAU - Wang, Chaowei AU - Wang C AUID- ORCID: 0009-0005-9351-600X AD - Collaborative Innovation Center of Endemic Disease and Health Promotion for Silk Road Region, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. AD - Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. FAU - Cui, Liangyu AU - Cui L AD - Department of Occupational and Environmental Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. AD - Collaborative Innovation Center of Endemic Disease and Health Promotion for Silk Road Region, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. FAU - Guo, Xiong AU - Guo X AD - Collaborative Innovation Center of Endemic Disease and Health Promotion for Silk Road Region, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. AD - Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. FAU - Wang, Xi AU - Wang X AUID- ORCID: 0000-0003-2983-5485 AD - Department of Occupational and Environmental Health, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. AD - Collaborative Innovation Center of Endemic Disease and Health Promotion for Silk Road Region, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. AD - Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. FAU - Ning, Yujie AU - Ning Y AD - Collaborative Innovation Center of Endemic Disease and Health Promotion for Silk Road Region, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. AD - Key Laboratory of Trace Elements and Endemic Diseases, National Health and Family Planning Commission, School of Public Health, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, China. LA - eng GR - 82273752/National Natural Science Foundation of China/ GR - 82373700/National Natural Science Foundation of China/ PT - Journal Article PT - Review DEP - 20261016 PL - Switzerland TA - Metabolites JT - Metabolites JID - 101578790 PMC - PMC13706950 OTO - NOTNLM OT - Kashin-Beck disease OT - T-2 toxin OT - dietary factors OT - gut microbiota OT - microbiota-gut-osteochondral framework COIS- The authors declare no conflict of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/10/16 CRDT- 2026/10/27 10:38 PHST- 2026/08/07 00:00 [received] PHST- 2026/10/14 00:00 [revised] PHST- 2026/10/14 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:38 [entrez] PHST- 2026/10/16 00:00 [pmc-release] AID - metabo16100787 [pii] AID - metabolites-16-00787 [pii] AID - 10.3390/metabo16100787 [doi] PST - epublish SO - Metabolites. 2026 Oct 16;16(10):787. doi: 10.3390/metabo16100787. PMID- 42940748 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 10 DP - 2026 Oct 18 TI - From Type 2 Inflammation to Mucociliary Dysfunction: Individualized Pulmonary Rehabilitation in Children with Asthma and Bronchiectasis. LID - 10.3390/children13101430 [doi] LID - 1430 AB - Asthma and bronchiectasis may coexist in children, particularly in those with severe or difficult-to-treat respiratory disease, creating a complex clinical setting in which airway inflammation, bronchial hyperresponsiveness, mucus retention, impaired mucociliary clearance, recurrent infection, and functional impairment interact. This review critically examines the interacting pathophysiological mechanisms involving Type 2 airway inflammation, mucus hypersecretion and plugging, mucociliary dysfunction, infection, and structural airway injury in children with coexisting asthma and bronchiectasis. Particular attention is given to the functional consequences of this interaction, including exercise intolerance, physical deconditioning, respiratory muscle dysfunction, and reduced participation in daily life and age-appropriate physical activity. Available evidence on airway-clearance techniques, structured exercise training, respiratory muscle training, and the management of exercise-induced bronchoconstriction is critically evaluated, with pediatric evidence clearly distinguished from adult-derived extrapolations. We propose a mechanism-informed rehabilitation framework in which interventions are tailored to the predominant clinical and functional features of each child, including mucus retention, bronchial hyperresponsiveness, reduced exercise capacity, respiratory muscle impairment, and functional decline associated with recurrent exacerbations. This multidisciplinary approach integrates airway-clearance techniques, individualized exercise training, optimized asthma management, infection control, and longitudinal functional reassessment. Evidence specifically addressing children with coexisting asthma and bronchiectasis remains limited, and prospective pediatric studies are required to validate individualized rehabilitation strategies and determine their impact on long-term respiratory and patient-centered outcomes. FAU - Vidrighin, Anca AU - Vidrighin A AD - Department of Paediatrics, Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania. FAU - Juganaru, Iulius AU - Juganaru I AUID- ORCID: 0009-0000-6879-145X AD - Department XI of Pediatrics, Discipline I of Pediatrics, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania. AD - Department of Pediatrics I, "Louis Turcanu" Children's Emergency Hospital, 300011 Timisoara, Romania. FAU - Iovin, Valentin-Cristian AU - Iovin VC AUID- ORCID: 0009-0004-1552-7961 AD - Doctoral School Department, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania. FAU - Diaconu, Cosmina AU - Diaconu C AUID- ORCID: 0000-0003-4845-8953 AD - Department of Nursing and Dental Medicine, Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania. AD - Clinic of Physical Medicine and Rehabilitation, County Clinical Emergency Hospital Sibiu, 550245 Sibiu, Romania. FAU - Neamtu, Andreea-Adriana AU - Neamtu AA AUID- ORCID: 0000-0002-5219-5466 AD - Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania. AD - Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania. AD - Department of Pathology, Clinical County Emergency Hospital of Arad, 310037 Arad, Romania. AD - Department of Pathology, "Pius Brinzeu" Clinical County Emergency Hospital, 300723 Timisoara, Romania. FAU - Sarau, Cristian AU - Sarau C AUID- ORCID: 0000-0002-1938-1443 AD - Medical Semiology I, Department V Internal Medicine I, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania. FAU - Lighezan, Diana Luisa AU - Lighezan DL AUID- ORCID: 0009-0002-8001-7672 AD - Department of Hematology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Diaconu, Cristinel Gabriel AU - Diaconu CG AUID- ORCID: 0009-0005-9133-4384 AD - Department of Physiology, Faculty of Medicine, Lucian Blaga University of Sibiu, Lucian Blaga Street 2A, 550169 Sibiu, Romania. AD - Department of Radiology, Pneumology and Tuberculosis Hospital, 550196 Sibiu, Romania. FAU - Porr, Corina AU - Porr C AUID- ORCID: 0009-0000-7255-0835 AD - Allergology Department, Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania. AD - Allergology Department, County Clinical Emergency Hospital Sibiu, Bulevardul Corneliu Coposu 2-4, 550245 Sibiu, Romania. LA - eng PT - Journal Article PT - Review DEP - 20261018 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13703761 OTO - NOTNLM OT - Type 2 inflammation OT - airway clearance OT - bronchiectasis OT - exercise training OT - exercise-induced bronchoconstriction OT - mucociliary dysfunction OT - pediatric asthma OT - pulmonary rehabilitation OT - respiratory muscle training COIS- The authors declare no conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/10/18 CRDT- 2026/10/27 10:37 PHST- 2026/09/06 00:00 [received] PHST- 2026/10/02 00:00 [revised] PHST- 2026/10/16 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:37 [entrez] PHST- 2026/10/18 00:00 [pmc-release] AID - children13101430 [pii] AID - children-13-01430 [pii] AID - 10.3390/children13101430 [doi] PST - epublish SO - Children (Basel). 2026 Oct 18;13(10):1430. doi: 10.3390/children13101430. PMID- 42940723 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 10 DP - 2026 Oct 14 TI - Children's Perception of Parental Body Size and Its Association with Their Desire to Be Like the Parent. LID - 10.3390/children13101404 [doi] LID - 1404 AB - BACKGROUND: Childhood obesity is a major and growing public health challenge worldwide. Although parental misperception of children's weight is well documented, how children perceive their parents' body size and whether parental body size is associated with children's expressed desire to be like the parent have received little attention. We examined children's perception of parental body size and whether parental BMI was associated with their expressed desire to be like the parent in a primary care sample. METHODS: This single-center, cross-sectional study included 229 parent-child pairs consecutively recruited from a family medicine outpatient clinic in Turkiye between January and March 2026. Children aged 4-8 years rated the accompanying parent's body size and reported whether they wanted to be like that parent, while parents independently rated their own body size. The BMI-based Body Size Guide was used for all figure selections, and the classification derived from objectively measured parental BMI served as the primary reference. Agreement was evaluated using Cohen's kappa coefficients, associations were examined using multivariable logistic regression, and the children's spontaneous explanations were examined using qualitative content analysis. RESULTS: Parents showed moderate weighted agreement with the BMI-derived classification (weighted kappa = 0.536, 95% CI: 0.456-0.612; exact agreement: 59.4%), whereas children showed fair weighted agreement (weighted kappa = 0.315, 95% CI: 0.231-0.392; exact agreement: 42.8%). After adjustment for child age, child sex, child weight status, parent sex, and parent age, parental overweight (aOR = 0.353, 95% CI: 0.170-0.733) and parental obesity (aOR = 0.133, 95% CI: 0.057-0.307) were associated with lower odds of the child reporting a desire to be like the parent. After adjustment for child age, child sex, parent sex, and parent age, parental overweight (aOR = 2.818, 95% CI: 1.101-7.211) and parental obesity (aOR = 4.774, 95% CI: 1.816-12.546) were associated with higher odds of child overweight/obesity. Among the 53 children who provided an explanation, responses referred to body size, weight, health, appearance, affection, and identification with the parent, illustrating the broad interpretation of the question. CONCLUSIONS: Children aged 4-8 years were able to rate parental body size, although their agreement with the BMI-derived classification was limited. Children's expressed desire to be like the parent varied according to parental BMI; however, this broad question may reflect emotional, relational, behavioural, and appearance-related considerations rather than bodily resemblance alone. The open-ended responses provide context by showing that only some children spontaneously referred to body size or weight. These findings support further research using developmentally validated and stigma-sensitive measures to clarify how young children perceive parental body size and interpret questions about identification with a parent. FAU - Kurt, Abdullah Kaan AU - Kurt AK AUID- ORCID: 0000-0002-6302-6035 AD - Department of Family Medicine, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkiye. FAU - Karakullukcu, Serdar AU - Karakullukcu S AUID- ORCID: 0000-0001-7673-7699 AD - Department of Public Health, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkiye. LA - eng PT - Journal Article DEP - 20261014 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13703376 OTO - NOTNLM OT - body image OT - body size OT - child OT - parent-child relations OT - pediatric obesity COIS- The authors declare that they have no competing interests. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/10/14 CRDT- 2026/10/27 10:37 PHST- 2026/09/07 00:00 [received] PHST- 2026/10/01 00:00 [revised] PHST- 2026/10/13 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:37 [entrez] PHST- 2026/10/14 00:00 [pmc-release] AID - children13101404 [pii] AID - children-13-01404 [pii] AID - 10.3390/children13101404 [doi] PST - epublish SO - Children (Basel). 2026 Oct 14;13(10):1404. doi: 10.3390/children13101404. PMID- 42940677 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 10 DP - 2026 Oct 7 TI - Overlap of Subcutaneous Adiposity Across World Health Organization Body Mass Index-for-Age Categories and Anthropometric Correlates of Handgrip Strength in Children Aged 6-12 Years Participating in Organised Club Sport in Buenos Aires, Argentina. LID - 10.3390/children13101358 [doi] LID - 1358 AB - Background/Objectives: Body mass index (BMI) is the most widely used screening tool in paediatric nutritional assessment, but it does not measure body fat directly and conveys no information on muscular development. We aimed to (i) compare the sum of six skinfolds (Sigma6ST) across World Health Organization (WHO) BMI-for-age categories, accounting for age; (ii) quantify the distributional overlap of Sigma6ST between categories; (iii) examine how closely each individual skinfold tracks the remaining subcutaneous adiposity; and (iv) examine the associations of upper-limb girths with handgrip strength before and after adjustment for body size. Methods: This was a cross-sectional study of a convenience sample of 196 children (129 boys, 67 girls) aged 6-12 years engaged in organised club sport in Moron, Buenos Aires, Argentina. International Society for the Advancement of Kinanthropometry (ISAK)-certified anthropometrists measured six skinfolds and relaxed arm, corrected arm and forearm girths; handgrip strength was assessed with a digital dynamometer. Analyses used Kruskal-Wallis and Brunner-Munzel tests, age-adjusted log-linear models with robust standard errors, kernel-density overlap coefficients (OVLs) with bootstrap confidence intervals, and zero-order and partial Spearman correlations. Results: In this sample, 47.3% of boys and 43.3% of girls were classified as having overweight or obesity. Age distributions were similar across BMI categories, and Sigma6ST differed across categories after age adjustment (p < 0.001 in both sexes). Adjacent WHO categories nevertheless overlapped substantially (OVL = 0.44-0.57), and the two halves of the normal-weight range overlapped by up to 0.757. Single skinfolds correlated strongly with the sum of the remaining five (rho = 0.777-0.945) but estimated Sigma6ST with a median absolute error of 8.5-14.1%. Handgrip strength correlated most strongly with body size (stature in boys, rho = 0.723; body mass in girls, rho = 0.759). After adjustment for age, body mass and stature, it remained associated with corrected arm girth (partial rho = 0.346 and 0.336) but not with relaxed arm girth. Conclusions: BMI-for-age categories separate groups on average but carry limited information about an individual child's subcutaneous adiposity. Skinfolds and corrected arm girth are low-cost complements to BMI whose individual-level value requires validation against criterion methods. FAU - Gimenez, Mariano Jose AU - Gimenez MJ AUID- ORCID: 0009-0008-6135-3519 AD - Catedra de Nutricion y Deporte, Escuela de Nutricion, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires C1121A6B, Argentina. AD - Red Iberoamericana de Investigadores en Antropometria Aplicada, 04120 Almeria, Spain. FAU - Herrera-Amante, Carlos Abraham AU - Herrera-Amante CA AUID- ORCID: 0000-0002-3645-3621 AD - Red Iberoamericana de Investigadores en Antropometria Aplicada, 04120 Almeria, Spain. AD - Laboratorio de Evaluacion y Cuidado del Estado Nutricio, Centro Universitario de Tonala, Division de Ciencias de la Salud, Universidad de Guadalajara, Tonala 45425, Jalisco, Mexico. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AUID- ORCID: 0000-0002-9311-6576 AD - Faculty of Education and Humanities, School of Sport Sciences, Universidad Andres Bello, Vina del Mar 2520000, Chile. AD - Department of Sport Sciences, Faculty of Sport and Health Sciences, Fit Generation Research Institute, AD500 Andorra la Vella, Andorra. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - School of Medicine, Universidad Espiritu Santo, Samborondon 092301, Ecuador. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno 5290000, Chile. LA - eng PT - Journal Article DEP - 20261007 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13702943 OTO - NOTNLM OT - anthropometry OT - body composition OT - body mass index OT - child OT - hand strength OT - paediatric obesity OT - skinfold thickness OT - youth sport COIS- M.J.G., C.A.H.-A., and R.Y.-S. are certified Level Three Anthropometrists (Instructors) by the International Society for the Advancement of Kinanthropometry (ISAK), who have received honoraria for teaching anthropometry courses and participating in international conferences. These professional interests relate to the field of anthropometry, which is the subject of the present manuscript, and are disclosed for full transparency; they did not influence the design, analysis or reporting of the study, and no author received any payment related to this manuscript. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/10/07 CRDT- 2026/10/27 10:37 PHST- 2026/09/02 00:00 [received] PHST- 2026/09/22 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:37 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - children13101358 [pii] AID - children-13-01358 [pii] AID - 10.3390/children13101358 [doi] PST - epublish SO - Children (Basel). 2026 Oct 7;13(10):1358. doi: 10.3390/children13101358. PMID- 42940674 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 10 DP - 2026 Oct 5 TI - Orthorexia Symptoms in Adolescents: Associations with Sociocultural Attitudes Toward Appearance and Body Composition. LID - 10.3390/children13101355 [doi] LID - 1355 AB - BACKGROUND/OBJECTIVES: Orthorexic symptoms in adolescence may be associated with sociocultural appearance influences, but their relationship with objective body composition remains unclear. This study examined associations between orthorexic symptoms, sociocultural attitudes toward appearance, and body composition in adolescents. METHODS: This cross-sectional study included 287 Polish secondary-school students aged 14-18 years. Orthorexic symptoms were assessed using the Dusseldorf Orthorexia Scale (DOS), sociocultural attitudes using the Sociocultural Attitudes Towards Appearance Questionnaire-3 (SATAQ-3), and body composition by bioelectrical impedance analysis. Correlation and multiple linear regression analyses were performed. RESULTS: DOS scores correlated positively with SATAQ-3 pressure/internalization (r = 0.407, p < 0.001), athletic internalization (r = 0.330, p < 0.001), and Information (r = 0.385, p < 0.001). These associations remained robust in Spearman sensitivity analyses. The regression model including four SATAQ-3 subscales, percentage body fat (PBF), sex, and age explained 19.2% of DOS-score variance (adjusted R(2) = 0.172; F(7.279) = 9.49, p < 0.001). Pressure/internalization (beta = 0.190, p = 0.053) and Information (beta = 0.162, p = 0.060) did not reach conventional statistical significance. The remaining predictors were not independently associated with DOS scores. CONCLUSIONS: Orthorexic symptom severity was associated with appearance-related sociocultural variables at the bivariate level, but individual predictors were not independently significant in the adjusted model. These findings identify sociocultural factors as relevant correlates without establishing causality or excluding a role for body composition. Longitudinal studies using adolescent-validated measures and direct assessments of digital exposure are needed. FAU - Kiciak, Agata AU - Kiciak A AUID- ORCID: 0000-0002-4531-2038 AD - Department of Food Technology and Quality Assessment, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland. FAU - Staskiewicz, Wiktoria AU - Staskiewicz W AUID- ORCID: 0000-0003-2420-5935 AD - Department of Food Technology and Quality Assessment, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland. FAU - Kuczka-Marek, Natalia AU - Kuczka-Marek N AUID- ORCID: 0009-0007-2144-6318 AD - Doctoral School, Medical University of Silesia in Katowice, 40-055 Katowice, Poland. FAU - Bialek-Dratwa, Agnieszka AU - Bialek-Dratwa A AUID- ORCID: 0000-0002-7798-6424 AD - Department of Human Nutrition, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland. FAU - Sapala, Anna-Maria AU - Sapala AM AUID- ORCID: 0009-0009-2558-5600 AD - Department of Dietetics and Food Science, Faculty of Science, Natural and Technical Sciences, Jan Dlugosz University in Czestochowa, Aleja Armii Krajowej 13/15, 42-200 Czestochowa, Poland. FAU - Jaruga-Sekowska, Sylwia AU - Jaruga-Sekowska S AUID- ORCID: 0000-0003-0142-2013 AD - Department of Health Promotion, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, ul. Piekarska 18, 41-902 Bytom, Poland. FAU - Kardas, Marek AU - Kardas M AUID- ORCID: 0000-0002-4810-1025 AD - Department of Food Technology and Quality Assessment, Department of Dietetics, Faculty of Public Health in Bytom, Medical University of Silesia in Katowice, ul. Jordana 19, 41-808 Zabrze, Poland. AD - Food Industry School, Franciszkanska 13, 41-819 Zabrze, Poland. FAU - Barczynska, Renata AU - Barczynska R AUID- ORCID: 0000-0002-4161-6480 AD - Department of Dietetics and Food Science, Faculty of Science, Natural and Technical Sciences, Jan Dlugosz University in Czestochowa, Aleja Armii Krajowej 13/15, 42-200 Czestochowa, Poland. LA - eng PT - Journal Article DEP - 20261005 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13703725 OTO - NOTNLM OT - adolescent mental health OT - body image OT - orthorexia nervosa OT - sociocultural pressure COIS- The authors declare no conflicts of interest. EDAT- 2026/10/27 11:32 MHDA- 2026/10/27 11:33 PMCR- 2026/10/05 CRDT- 2026/10/27 10:37 PHST- 2026/08/17 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/27 11:33 [medline] PHST- 2026/10/27 11:32 [pubmed] PHST- 2026/10/27 10:37 [entrez] PHST- 2026/10/05 00:00 [pmc-release] AID - children13101355 [pii] AID - children-13-01355 [pii] AID - 10.3390/children13101355 [doi] PST - epublish SO - Children (Basel). 2026 Oct 5;13(10):1355. doi: 10.3390/children13101355. PMID- 42939470 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261027 LR - 20261028 IS - 2079-7737 (Print) IS - 2079-7737 (Electronic) IS - 2079-7737 (Linking) VI - 15 IP - 20 DP - 2026 Oct 16 TI - Maternal Pharmaceutical Intake, Tobacco Smoking, and Environmental Pesticide Exposures: High-Resolution Serum Pesticide Screening, Longitudinal Fetal Ultrasound Biometry, and Postnatal Anogenital Distance in a Brazilian Cohort. LID - 10.3390/biology15201869 [doi] LID - 1869 AB - Maternal lifestyle exposures and pharmaceutical consumption during gestation represent key modulators of intrauterine growth and reproductive tract programming. This prospective cohort study evaluated the associations of maternal clinical history, medication use, and tobacco smoking with serial fetal ultrasound biometry, AGD, and postnatal infant anthropometry. A cohort of 51 pregnant women was prospectively enrolled during the first trimester (1 episode/h on PSG. Videos (>/=5 min) of the head and exposed torso were captured at home. Snore, type of inspiratory noise, respiratory events, respiratory effort, mouth breathing and neck extension were scored using a modified scoring system. The Sleep Disturbance Scale for Children (SDSC) was completed. Sleep video scores were then combined with brief demographic and anthropometric data and SDSC results using logistic regression to develop an OSA screening model. RESULTS: 194 children were recruited, and 91 technically satisfactory videos were returned (29F; mean (SD) age 8.9 (3.0) years; median (IQR) body mass index (BMI) z-score 1.1 (0.3-2.1)). 26 (28.6%) children had OSA on PSG. Total video score >/=1 predicted OSA with sensitivity 80.8%, specificity 67.2% and area under the receiver operating characteristic curve (AUC) 0.74. A multivariate logistic regression model incorporating total video score, BMI z-score and SDSC subscale score predicted OSA with sensitivity 94.4%, negative predictive value 96.9% and AUC 0.89. CONCLUSIONS: We have found a single, short sleep video captured at a time convenient for the parent/caregiver to be a promising, simple and inexpensive screening modality for paediatric OSA. The addition of easily obtained demographic, anthropometric and questionnaire-based items resulted in a high sensitivity, supporting ongoing investigation of this modality and its utility in streamlining PSG access for those at highest risk of OSA while allowing lower-risk children to follow a watch-and-wait approach. FAU - Daniels, Celeste AU - Daniels C AUID- ORCID: 0000-0001-7919-4511 AD - Department of Respiratory and Sleep Medicine, Queensland Children's Hospital, South Brisbane, Queensland, Australia celeste.daniels@uqconnect.edu.au. AD - Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia. FAU - Kapur, Nitin AU - Kapur N AD - Department of Respiratory and Sleep Medicine, Queensland Children's Hospital, South Brisbane, Queensland, Australia. AD - Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia. FAU - Ware, Robert S AU - Ware RS AD - Griffith Biostatistics Unit, Griffith University, Brisbane, Queensland, Australia. AD - Wesley Research Institute, Brisbane, Queensland, Australia. FAU - Gauld, Leanne AU - Gauld L AUID- ORCID: 0000-0003-0819-894X AD - Department of Respiratory and Sleep Medicine, Queensland Children's Hospital, South Brisbane, Queensland, Australia. AD - Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia. LA - eng PT - Journal Article DEP - 20261026 PL - England TA - BMJ Open Respir Res JT - BMJ open respiratory research JID - 101638061 SB - IM PMC - PMC13711606 OTO - NOTNLM OT - Sleep apnoea EDAT- 2026/10/26 23:27 MHDA- 2026/10/26 23:27 PMCR- 2026/10/26 CRDT- 2026/10/26 20:53 PHST- 2026/02/15 00:00 [received] PHST- 2026/09/24 00:00 [accepted] PHST- 2026/10/26 23:27 [medline] PHST- 2026/10/26 23:27 [pubmed] PHST- 2026/10/26 20:53 [entrez] PHST- 2026/10/26 00:00 [pmc-release] AID - 13/1/e004187 [pii] AID - bmjresp-2026-004187 [pii] AID - 10.1136/bmjresp-2026-004187 [doi] PST - epublish SO - BMJ Open Respir Res. 2026 Oct 26;13(1):e004187. doi: 10.1136/bmjresp-2026-004187. PMID- 42933650 OWN - NLM STAT- Publisher LR - 20261026 IS - 1541-6100 (Electronic) IS - 0022-3166 (Linking) DP - 2026 Oct 26 TI - Correction-free quantification of retinol in dried blood spots from children: agreement with plasma concentrations and plasma-based classification of vitamin A inadequacy. PG - 101908 LID - S0022-3166(26)00557-2 [pii] LID - 10.1016/j.tjnut.2026.101908 [doi] AB - BACKGROUND: Vitamin A (VA) inadequacy (VAI) remains prevalent among Chinese children, but venous sampling for plasma retinol can constrain large-scale monitoring. Dried blood spot (DBS) sampling is minimally invasive, although many existing methods rely on population-specific correction factors. A previously described serum-based calibration approach offers correction-free quantification, but its performance across the pediatric hematocrit (HCT) range requires evaluation. OBJECTIVE: To evaluate correction-free DBS retinol measurement against paired plasma retinol in children, assessing agreement, plasma-based VAI classification, HCT associations, and interlaboratory reproducibility. METHODS: Paired plasma and DBS samples from 85 children younger than 9 y (20 aged <6 mo) were analyzed. Agreement was assessed using the intraclass correlation coefficient (ICC), overlap coefficient (OVL), Passing-Bablok regression, and Bland-Altman analysis. VAI classification was compared using cutoffs of 1.05 mumol/L for children aged >/=6 mo and an exploratory cutoff of 0.489 mumol/L for infants aged <6 mo. The WHO deficiency cutoff of 0.70 mumol/L was evaluated as a secondary threshold. HCT associations and three-site reproducibility (23 samples) were assessed. RESULTS: DBS and plasma retinol showed high agreement (ICC 0.918; OVL 0.939). Mean bias was +0.035 mumol/L (95% limits of agreement: -0.388 to +0.458). Passing-Bablok analysis detected no significant constant or proportional bias. DBS reproduced plasma-based VAI classification with 92.9% accuracy (Youden's J 0.862; sensitivity 93.3%; specificity 92.9%). HCT was inversely associated with the DBS-plasma difference (rho = -0.242, P = 0.026), with absolute mean biases across HCT categories /= 0.18; AUC 0.50-0.64), and the LAR was collinear with lactate (rho = 0.95). The weight-for-age z-score correlated with vitamin C (rho = 0.39, p = 0.033). CONCLUSIONS: In this small cohort, non-survivors had lower plasma vitamin C concentrations within the replete range in unadjusted analysis; this difference did not persist after FDR control or in the subgroup with evaluable nutritional status, and nutritional confounding cannot be excluded. No association with mortality was detected for 25(OH)D, lactate, albumin, or the LAR. These findings are hypothesis-generating, do not establish prognostic value, and require multicenter confirmation. FAU - Martinez-Garcia, Jesus J AU - Martinez-Garcia JJ AUID- ORCID: 0000-0002-9555-262X AD - Pediatric Hospital of Sinaloa, Culiacan 80200, Sinaloa, Mexico. AD - School of Medicine, Autonomous University of Sinaloa, Culiacan 80019, Sinaloa, Mexico. FAU - Canizalez-Roman, Adrian AU - Canizalez-Roman A AUID- ORCID: 0000-0001-8605-0639 AD - School of Medicine, Autonomous University of Sinaloa, Culiacan 80019, Sinaloa, Mexico. AD - The Women's Hospital, Secretariat of Health, Culiacan 80020, Sinaloa, Mexico. FAU - Zatarain-Lopez, Ricardo AU - Zatarain-Lopez R AD - Centro de Investigacion y Docencia en Ciencias de la Salud (CIDOCS), Autonomous University of Sinaloa, Culiacan 80030, Sinaloa, Mexico. FAU - Cazarez-Aguilar, Marcel Antonio AU - Cazarez-Aguilar MA AD - Centro de Investigacion y Docencia en Ciencias de la Salud (CIDOCS), Autonomous University of Sinaloa, Culiacan 80030, Sinaloa, Mexico. FAU - Bolivar-Rodriguez, Martin Adrian AU - Bolivar-Rodriguez MA AUID- ORCID: 0000-0002-7666-7974 AD - Centro de Investigacion y Docencia en Ciencias de la Salud (CIDOCS), Autonomous University of Sinaloa, Culiacan 80030, Sinaloa, Mexico. FAU - Velazquez-Lopez, Luis AU - Velazquez-Lopez L AD - Pediatric Hospital of Sinaloa, Culiacan 80200, Sinaloa, Mexico. FAU - Osuna-Ramirez, Carlos Alberto AU - Osuna-Ramirez CA AD - Pediatric Hospital of Sinaloa, Culiacan 80200, Sinaloa, Mexico. FAU - Correa-Flores, Manuel A AU - Correa-Flores MA AD - IMSS Bienestar Legaria Pediatric Hospital, Mexico City 11260, Mexico. FAU - Garcia-de Leon, Maria Fernanda AU - Garcia-de Leon MF AD - Pediatric Hospital of Sinaloa, Culiacan 80200, Sinaloa, Mexico. FAU - Acosta-Smith, Erika AU - Acosta-Smith E AUID- ORCID: 0000-0001-8313-6699 AD - School of Medicine, Autonomous University of Sinaloa, Culiacan 80019, Sinaloa, Mexico. FAU - Velazquez-Roman, Jorge AU - Velazquez-Roman J AD - School of Medicine, Autonomous University of Sinaloa, Culiacan 80019, Sinaloa, Mexico. FAU - Flores-Villasenor, Hector AU - Flores-Villasenor H AD - School of Medicine, Autonomous University of Sinaloa, Culiacan 80019, Sinaloa, Mexico. FAU - Angulo-Zamudio, Uriel A AU - Angulo-Zamudio UA AUID- ORCID: 0000-0003-2733-0766 AD - School of Medicine, Autonomous University of Sinaloa, Culiacan 80019, Sinaloa, Mexico. FAU - Leon-Sicairos, Nidia AU - Leon-Sicairos N AUID- ORCID: 0000-0003-1470-3383 AD - Pediatric Hospital of Sinaloa, Culiacan 80200, Sinaloa, Mexico. AD - School of Medicine, Autonomous University of Sinaloa, Culiacan 80019, Sinaloa, Mexico. LA - eng PT - Journal Article DEP - 20261002 PL - Switzerland TA - Pediatr Rep JT - Pediatric reports JID - 101551542 PMC - PMC13708177 OTO - NOTNLM OT - 25-hydroxyvitamin D OT - Phoenix criteria OT - ascorbic acid OT - lactate-to-albumin ratio OT - mortality OT - pediatric intensive care unit OT - pediatric sepsis OT - vitamin C COIS- The authors declare no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The authors declare no conflicts of interest. EDAT- 2026/10/26 17:31 MHDA- 2026/10/26 17:32 PMCR- 2026/10/02 CRDT- 2026/10/26 11:13 PHST- 2026/08/25 00:00 [received] PHST- 2026/09/28 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/26 17:32 [medline] PHST- 2026/10/26 17:31 [pubmed] PHST- 2026/10/26 11:13 [entrez] PHST- 2026/10/02 00:00 [pmc-release] AID - pediatric18050132 [pii] AID - pediatrrep-18-00132 [pii] AID - 10.3390/pediatric18050132 [doi] PST - epublish SO - Pediatr Rep. 2026 Oct 2;18(5):132. doi: 10.3390/pediatric18050132. PMID- 42931089 OWN - NLM STAT- Publisher LR - 20261026 IS - 1911-9828 (Electronic) IS - 0008-4174 (Linking) DP - 2026 Oct 26 TI - Test-retest Reliability of Creyos Test Battery in Adolescents at Risk of Concussion. PG - 84174261488757 LID - 10.1177/00084174261488757 [doi] AB - Background: Creyos is a computerized neurocognitive test battery that is widely used to assess cognition. Purpose: To evaluate the test-retest reliability of Creyos subtests for adolescents. Method: Reliability was analyzed using intraclass correlation coefficients and Bland-Altman 95% limits of agreement. Linear mixed-effects models were employed to examine change in scores over time for each subtest (a) overall; and (b) by sex. Findings: Participants included 71 adolescents ages 12-18 (median age 15, 49% female) who participated in at least one sport with a high risk of concussion. Results indicated poor-to-moderate reliability and wide limits of agreement across all subtests. Learning effects were apparent on several subtests; one subtest showed learning effects for both females and males. One subtest showed a significant difference in reliability between sexes. Conclusion: Reliability was poor-to-moderate across all subtests. Generally, reliability and learning effects did not differ by sex. Given concerns about the reliability of Creyos, occupational therapists should exercise caution when interpreting test scores to inform return to school and sport management in adolescents post-concussion. In the future, randomizing the order of subtest presentation and standardizing the test administration process may provide greater insight into the reliability of Creyos in adolescents. FAU - Shepherd, Heather A AU - Shepherd HA AUID- ORCID: 0000-0003-0665-8674 AD - School of Occupational Therapy, Faculty of Health Sciences, Western University, London, Canada. RINGGOLD: 6221 AD - Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Canada. RINGGOLD: 2129 FAU - Galarneau, Jean-Michel AU - Galarneau JM AUID- ORCID: 0000-0003-3784-8753 AD - Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada. RINGGOLD: 157744. RINGGOLD: 2129 AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - O'Brien Institute for Public Health, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Canada. RINGGOLD: 2129 FAU - Faris, Emily K AU - Faris EK AD - Independent Scholar. FAU - Yeates, Keith O AU - Yeates KO AUID- ORCID: 0000-0001-7680-2892 AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada. RINGGOLD: 157744. RINGGOLD: 2129 AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - Department of Psychology, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Canada. RINGGOLD: 2129 FAU - Emery, Carolyn A AU - Emery CA AUID- ORCID: 0000-0002-9499-6691 AD - Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada. RINGGOLD: 157744. RINGGOLD: 2129 AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - O'Brien Institute for Public Health, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - McCaig Institute for Bone and Joint Health, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Canada. RINGGOLD: 2129 AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Canada. RINGGOLD: 2129 LA - eng PT - Journal Article DEP - 20261026 PL - United States TA - Can J Occup Ther JT - Canadian journal of occupational therapy. Revue canadienne d'ergotherapie JID - 0406021 SB - IM OTO - NOTNLM OT - Adolescent OT - Adolescents OT - Assessment OT - Commotion cerebrale OT - Concussion OT - Digital technology OT - Fiabilite OT - Reliability OT - Technologie numerique OT - Evaluation EDAT- 2026/10/26 17:31 MHDA- 2026/10/26 17:31 CRDT- 2026/10/26 11:13 PHST- 2026/10/26 17:31 [medline] PHST- 2026/10/26 17:31 [pubmed] PHST- 2026/10/26 11:13 [entrez] AID - 10.1177/00084174261488757 [doi] PST - aheadofprint SO - Can J Occup Ther. 2026 Oct 26:84174261488757. doi: 10.1177/00084174261488757. PMID- 42930806 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261026 LR - 20261028 IS - 2075-4426 (Print) IS - 2075-4426 (Electronic) IS - 2075-4426 (Linking) VI - 16 IP - 10 DP - 2026 Oct 16 TI - Beyond Mallampati: From Universal Bedside Tests to Precision Airway Risk Stratification. LID - 10.3390/jpm16100532 [doi] LID - 532 AB - Airway management remains one of the few domains of anaesthetic practice still governed by universal, dichotomous screening thresholds applied to profoundly heterogeneous populations. Conventional bedside tests-the modified Mallampati test, thyromental distance and the upper lip bite test-retain modest and inconsistent diagnostic accuracy, leaving the majority of difficult intubations unanticipated while generating false alarms that drive resource-intensive contingency plans. This narrative review reframes preoperative airway evaluation as a problem of individualised risk stratification rather than population screening. We first summarise the performance limits of classical bedside predictors and the reasons for their ceiling effect, including low target prevalence, inter-observer variability, spectrum bias and heterogeneous outcome definitions. We then examine the data streams reshaping the field: point-of-care upper airway ultrasound, whose parameters provide operator-accessible and objective anatomical information; cross-sectional and craniofacial imaging; and machine-learning models based on clinical variables, facial images and voice analysis. For each we discuss accuracy, reproducibility, validation status and barriers to adoption. We then propose a phenotype-oriented framework in which assessment intensity is matched to pre-test probability, with dedicated pathways for obesity and obstructive sleep apnoea, obstetric, head-and-neck oncological and post-radiotherapy, critically ill and emergency, and paediatric populations. We map this framework onto the 2025 European Society of Anaesthesiology and Intensive Care and Difficult Airway Society recommendations and outline the validation, calibration and equity requirements-including algorithmic bias across skin tone, sex and ethnicity-that must be met before precision airway assessment can enter routine practice. FAU - Paterno, Daniele Salvatore AU - Paterno DS AUID- ORCID: 0009-0003-0215-5620 AD - Department of Anaesthesia and Intensive Care, "Giovanni Paolo II" Hospital, 97100 Ragusa, Italy. FAU - La Via, Luigi AU - La Via L AUID- ORCID: 0000-0002-2156-7554 AD - Department of General Surgery and Medical Surgical Specialties, University of Catania, 95123 Catania, Italy. FAU - Arena, Flavia Paola AU - Arena FP AD - Postgraduate School of Anaesthesia and Intensive Care, "Kore" University, 94100 Enna, Italy. FAU - Barbagallo, Francesca AU - Barbagallo F AD - Postgraduate School of Anaesthesia and Intensive Care, "Kore" University, 94100 Enna, Italy. FAU - Cala, Basilio Davide Lesina AU - Cala BDL AUID- ORCID: 0009-0002-7764-224X AD - Postgraduate School of Anaesthesia and Intensive Care, "Kore" University, 94100 Enna, Italy. FAU - Giudice, Emilia Concetta Lo AU - Giudice ECL AD - Department of Anaesthesia and Intensive Care, "Umberto I" Hospital, 94100 Enna, Italy. AD - School of Medicine, Anaesthesia and Intensive Care, "Kore" University, 94100 Enna, Italy. FAU - Cataldo, Rita AU - Cataldo R AUID- ORCID: 0000-0002-5821-6133 AD - Unit of Anaesthesia and Intensive Care, Fondazione Policlinico Universitario Campus Bio-Medico, 00128 Rome, Italy. AD - Research Unit of Anaesthesia and Intensive Care, Department of Medicine and Surgery, Universita Campus Bio-Medico, 00128 Rome, Italy. FAU - Sorbello, Massimiliano AU - Sorbello M AUID- ORCID: 0000-0002-9331-2788 AD - Department of Anaesthesia and Intensive Care, "Giovanni Paolo II" Hospital, 97100 Ragusa, Italy. AD - School of Medicine, Anaesthesia and Intensive Care, "Kore" University, 94100 Enna, Italy. LA - eng PT - Journal Article PT - Review DEP - 20261016 PL - Switzerland TA - J Pers Med JT - Journal of personalized medicine JID - 101602269 PMC - PMC13706562 OTO - NOTNLM OT - airway management OT - difficult intubation OT - machine learning OT - patient phenotype OT - perioperative care OT - personalised medicine OT - point-of-care ultrasound OT - precision medicine OT - risk stratification OT - videolaryngoscopy COIS- M.S. has received paid consultancy from Teleflex Medical, Verathon Medical and DEAS Italia; he is a patent co-owner (no royalties) of DEAS Italia. M.S. has signed non-disclosure agreements with Flexicare (UK) and AiEndoscopic (Switzerland), and has received paid consultancy from Flexicare (UK). M.S. is a member of the PUMA Writing Group and immediate past President of the European Airway Management Society (EAMS). L.L.V. and D.S.P. have signed a non-disclosure agreement with AiEndoscopic (Switzerland). E.C.L.G., F.P.A., F.B., B.D.L.C. and R.C. declare no conflicts of interest. EDAT- 2026/10/26 17:31 MHDA- 2026/10/26 17:32 PMCR- 2026/10/16 CRDT- 2026/10/26 11:04 PHST- 2026/08/20 00:00 [received] PHST- 2026/09/15 00:00 [revised] PHST- 2026/10/14 00:00 [accepted] PHST- 2026/10/26 17:32 [medline] PHST- 2026/10/26 17:31 [pubmed] PHST- 2026/10/26 11:04 [entrez] PHST- 2026/10/16 00:00 [pmc-release] AID - jpm16100532 [pii] AID - jpm-16-00532 [pii] AID - 10.3390/jpm16100532 [doi] PST - epublish SO - J Pers Med. 2026 Oct 16;16(10):532. doi: 10.3390/jpm16100532. PMID- 42930431 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261026 LR - 20261028 IS - 2304-6767 (Electronic) IS - 2304-6767 (Linking) VI - 14 IP - 10 DP - 2026 Oct 12 TI - Adaptation and Retention of Digitally Fabricated Presurgical Orthopedic Plates for Infants with Cleft Lip and Palate. LID - 10.3390/dj14100665 [doi] LID - 665 AB - Objectives: This study aimed to evaluate the fitness and retention of presurgical infant orthopedic (PSIO) plates fabricated from three materials-polyethylene terephthalate glycol-modified (PETG), PETG/polyurethane (PETG/TPU), and direct-printed Tera Harz resin-within a standardized in vitro framework. Methods: Thirty molding plates (ten per material) were fabricated on stereolithographic models. Fitness was assessed virtually using Exocad software DentalCAD 3.3 SR1 (exocad GmbH, Darmstadt, Germany), with gap distances measured at 36 standardized points across anterior, middle, and posterior regions. Statistical analysis was performed using Welch's ANOVA and Games-Howell post hoc comparisons. Retention was tested on soft gum casts using a digital force gauge under simulated intraoral conditions. Plates were seated with denture adhesive, pressurized, and subjected to perpendicular traction until detachment. Mean retentive force was calculated from three repeated trials per plate. Results: PETG plates demonstrated the closest adaptation (0.226 +/- 0.060 mm), significantly outperforming direct-printed plates (0.386 +/- 0.120 mm; p = 0.006). PETG/TPU plates showed intermediate values (0.321 +/- 0.134 mm) without significant deviation from either group. Region-specific analysis revealed the greatest misfit anteriorly, with PETG consistently achieving superior conformity. PETG exhibited the highest mean retentive force (4.30 N), significantly greater than PETG/TPU (2.28 N) and direct-printed plates (0.93 N; p < 0.001). PETG/TPU also performed significantly better than direct-printed plates. Conclusions: Material choice critically influences both the fit and retention of PSIO plates. PETG demonstrated more favorable adaptation and retention under controlled experimental conditions, suggesting potential advantages for appliance stability in presurgical infant orthopedic applications, while PETG/TPU offered moderate performance and direct-printed plates showed the weakest outcomes. Nonetheless, claims of clinical reliability or material superiority cannot be substantiated without further validation. Comprehensive longitudinal clinical studies are therefore required to confirm these preliminary observations and establish their relevance in patient care. FAU - Shakir, Fatima AU - Shakir F AD - Department of Orthodontic, College of Dentistry, University of Baghdad, Baghdad 10001, Iraq. FAU - Abid, Mushriq AU - Abid M AUID- ORCID: 0000-0001-8171-7465 AD - Department of Orthodontic, College of Dentistry, University of Baghdad, Baghdad 10001, Iraq. LA - eng PT - Journal Article DEP - 20261012 PL - Switzerland TA - Dent J (Basel) JT - Dentistry journal JID - 101716125 PMC - PMC13703680 OTO - NOTNLM OT - PETG OT - PETG/TPU OT - accuracy OT - cleft lip and palate OT - direct printed plates OT - fitness OT - presurgical orthopedics COIS- The authors have no conflicts of interest to declare. EDAT- 2026/10/26 11:29 MHDA- 2026/10/26 11:30 PMCR- 2026/10/12 CRDT- 2026/10/26 10:55 PHST- 2026/08/02 00:00 [received] PHST- 2026/09/29 00:00 [revised] PHST- 2026/10/08 00:00 [accepted] PHST- 2026/10/26 11:30 [medline] PHST- 2026/10/26 11:29 [pubmed] PHST- 2026/10/26 10:55 [entrez] PHST- 2026/10/12 00:00 [pmc-release] AID - dj14100665 [pii] AID - dentistry-14-00665 [pii] AID - 10.3390/dj14100665 [doi] PST - epublish SO - Dent J (Basel). 2026 Oct 12;14(10):665. doi: 10.3390/dj14100665. PMID- 42929285 OWN - NLM STAT- MEDLINE DCOM- 20261026 LR - 20261027 IS - 1478-9523 (Electronic) IS - 1478-9515 (Linking) VI - 24 DP - 2026 Oct 26 TI - Preliminary feasibility, acceptability, and "proof of concept" of a cultural adaptation of meaning-centered psychotherapy for Chinese immigrants with advanced cancer (MCP-Ch). PG - e281 LID - 10.1017/S147895152610354X [doi] AB - OBJECTIVES: To determine the preliminary feasibility, acceptability, and effects of the "Meaning-in-Life Counseling Program," a cultural adaptation of meaning-centered psychotherapy for Chinese immigrants with advanced cancer (MCP-Ch). METHODS: Mandarin-speaking stage III/IV cancer patients were enrolled in 2 pilot trials of MCP-Ch, a manualized, one-on-one intervention that used psychoeducation, experiential exercises, and structured discussion to explore themes related to meaning, identity, and purpose. Participants completed 6 weekly sessions in Mandarin Chinese with a bilingual interventionist, 45-60 minutes in length, via videoconferencing or phone. Participants were administered measures of spiritual well-being, quality of life (QOL), depression, anxiety, hopelessness, and meaning-in-life pre-intervention (T1) and 1-month post-intervention (T2) and were additionally administered an exit survey at T2. Descriptive data from participants who initiated MCP-Ch sessions (n = 31) were pooled. RESULTS: In total, 31 of 42 participants across the 2 trials started the MCP-Ch intervention, and 28 completed all 6 sessions. Results showed small to moderate postintervention improvements in spiritual well-being, QOL, anxiety, and depression. Participants provided positive feedback about MCP-Ch (89% expressed satisfaction with the intervention). A majority (50-86%) suggested additional components (i.e., cancer health education, Chinese-language peer support) to increase the intervention's relevance and acceptability. SIGNIFICANCE OF RESULTS: Overall, preliminary data suggest that this 6-session, manualized intervention is associated with improvements in psychological functioning. However, feedback from stakeholders suggests additional components could enhance the intervention's relevance. Future research should examine MCP-Ch with these additional components. FAU - Lui, Florence AU - Lui F AUID- ORCID: 0000-0001-6434-701X AD - Immigrant Health and Cancer Disparities Service, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ROR: https://ror.org/02yrq0923 FAU - Leng, Jennifer AU - Leng J AD - Immigrant Health and Cancer Disparities Service, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ROR: https://ror.org/02yrq0923 FAU - Lichtenthal, Wendy G AU - Lichtenthal WG AUID- ORCID: 0000-0003-3597-7826 AD - Psychiatry & Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. ROR: https://ror.org/02yrq0923 FAU - Costas-Muniz, Rosario AU - Costas-Muniz R AUID- ORCID: 0000-0003-0942-5657 AD - Psychiatry & Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. ROR: https://ror.org/02yrq0923 FAU - Chang, Fennie AU - Chang F AD - Immigrant Health and Cancer Disparities Service, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ROR: https://ror.org/02yrq0923 FAU - Kasuga, Emily AU - Kasuga E AD - Immigrant Health and Cancer Disparities Service, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ROR: https://ror.org/02yrq0923 FAU - Zhao, Corina AU - Zhao C AD - Immigrant Health and Cancer Disparities Service, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ROR: https://ror.org/02yrq0923 FAU - Li, Yuelin AU - Li Y AD - Psychiatry & Behavioral Sciences, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. ROR: https://ror.org/02yrq0923 FAU - Gany, Francesca AU - Gany F AD - Immigrant Health and Cancer Disparities Service, Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ROR: https://ror.org/02yrq0923 FAU - Breitbart, Bill AU - Breitbart B AD - Memorial Sloan-Kettering Cancer Center, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. LA - eng GR - 1R03CA267333-01A1,P30 CA008748,T32CA009461,U54CA137788 & U54CA132378/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20261026 PL - England TA - Palliat Support Care JT - Palliative & supportive care JID - 101232529 RN - Chinese people SB - IM MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Adaptation, Psychological MH - China/ethnology MH - *Emigrants and Immigrants/psychology/statistics & numerical data MH - Feasibility Studies MH - *Neoplasms/psychology/complications/therapy MH - Pilot Projects MH - *Psychotherapy/methods/standards MH - Quality of Life/psychology MH - Surveys and Questionnaires MH - Adolescent MH - Young Adult MH - East Asian People OTO - NOTNLM OT - Chinese Americans OT - cultural adaptation OT - existential OT - meaning-centered psychotherapy OT - psychotherapy EDAT- 2026/10/26 11:29 MHDA- 2026/10/26 11:30 CRDT- 2026/10/26 06:44 PHST- 2026/10/26 11:30 [medline] PHST- 2026/10/26 11:29 [pubmed] PHST- 2026/10/26 06:44 [entrez] AID - S147895152610354X [pii] AID - 10.1017/S147895152610354X [doi] PST - epublish SO - Palliat Support Care. 2026 Oct 26;24:e281. doi: 10.1017/S147895152610354X. PMID- 42928691 OWN - NLM STAT- MEDLINE DCOM- 20261026 LR - 20261029 IS - 1578-2735 (Electronic) IS - 1139-9287 (Print) IS - 1139-9287 (Linking) VI - 54 IP - 5 DP - 2026 Oct 15 TI - Association Among Systemic Immune-Inflammation Index, Vitamin D Status and Clinical Subtypes of ADHD: A Retrospective Investigation. PG - 1514-1526 LID - 10.62641/aep.2224 [doi] AB - BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) has been linked to immune dysregulation and nutritional imbalance. The systemic immune-inflammation index (SII) is a composite inflammatory marker, while serum 25-hydroxyvitamin D (25(OH)D) reflects vitamin D status. Their joint association with paediatric ADHD remains incompletely characterised. METHODS: In this retrospective case-control study, 78 treatment-naive children with ADHD and 40 non-ADHD outpatient comparison children selected using frequency matching by age and sex were included. The most recent laboratory results available in the outpatient record were extracted. Given that some 25(OH)D values were derived from reports obtained outside our hospital, all available 25(OH)D records were manually re-checked against source documents and standardised to ng/mL prior to analysis. Group comparisons, whole-sample Spearman correlation analyses, logistic regression models including an interaction term between standardised SII and standardised 25(OH)D and exploratory receiver operating characteristic (ROC) analyses were performed. Sensitivity analysis and Firth penalised logistic regression were additionally conducted. RESULTS: Compared with the comparison group, children with ADHD had significantly higher SII, C-reactive protein (CRP), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) levels, together with lower serum 25(OH)D. The ADHD group was more likely to fall into lower clinically defined 25(OH)D categories, whereas the comparison group was more frequently in the >/=30 ng/mL category; this pattern remained directionally consistent after stratification by season of blood draw. In the whole study sample, SII was positively correlated with attention, impulsivity and oppositional scores, whereas serum 25(OH)D was inversely correlated with these symptom dimensions; SII was also inversely correlated with 25(OH)D. In the parsimonious model, the interaction term between standardised SII and standardised 25(OH)D was statistically significant (odds ratio (OR) = 3.06, 95% confidence interval (CI) 1.59-6.80, p = 0.002), and it remained significant in the broader sensitivity model and Firth penalised regression. In exploratory within-sample analysis, ROC curves yielded area under curves (AUCs) of 0.808 for SII, 0.781 for serum 25(OH)D and 0.836 for the parsimonious multivariable model. CONCLUSIONS: Paediatric ADHD was associated with high inflammatory burden and low serum 25(OH)D status in this retrospective outpatient sample. The statistically significant interaction between SII and 25(OH)D suggests a stable pattern of effect modification on the logistic model scale. These findings support a potentially relevant immuno-nutritional pattern in ADHD, but prospective validation is needed before causal interpretation or clinical implementation can be considered. FAU - Lu, Tingting AU - Lu T AD - Department of Child Health Care, Dongyang Maternal and Child Health Hospital, 322100 Jinhua, Zhejiang, China. FAU - Chen, Yingying AU - Chen Y AD - Department of Child Health Care, Dongyang Maternal and Child Health Hospital, 322100 Jinhua, Zhejiang, China. FAU - Hu, Feiping AU - Hu F AD - Department of Child Health Care, Dongyang Maternal and Child Health Hospital, 322100 Jinhua, Zhejiang, China. FAU - Zhu, Yingping AU - Zhu Y AD - Healthcare Department, Dongyang Maternal and Child Health Hospital, 322100 Jinhua, Zhejiang, China. LA - eng PT - Journal Article DEP - 20261015 PL - Spain TA - Actas Esp Psiquiatr JT - Actas espanolas de psiquiatria JID - 100886502 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Humans MH - Retrospective Studies MH - *Attention Deficit Disorder with Hyperactivity/blood/immunology/complications MH - Male MH - Female MH - Case-Control Studies MH - *Vitamin D/blood/analogs & derivatives MH - *Inflammation/blood/complications MH - Child PMC - PMC13714461 COIS- The authors declare no conflict of interest. EDAT- 2026/10/26 05:30 MHDA- 2026/10/26 05:31 PMCR- 2026/10/15 CRDT- 2026/10/26 03:13 PHST- 2026/02/24 00:00 [received] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/10/26 05:31 [medline] PHST- 2026/10/26 05:30 [pubmed] PHST- 2026/10/26 03:13 [entrez] PHST- 2026/10/15 00:00 [pmc-release] AID - 10.62641/aep.2224 [pii] AID - 10.62641/aep.2224 [doi] PST - epublish SO - Actas Esp Psiquiatr. 2026 Oct 15;54(5):1514-1526. doi: 10.62641/aep.2224. PMID- 42928329 OWN - NLM STAT- Publisher LR - 20261026 IS - 1573-6695 (Electronic) IS - 1389-4986 (Linking) DP - 2026 Oct 26 TI - Concept Mapping Analysis of Sustainability Factors and Strategies for Childhood Obesity Prevention Programs. LID - 10.1007/s11121-026-02001-2 [doi] AB - This study aimed to identify and prioritize sustainability factors and strategies and to explore their relationships based on expert-informed concept mapping analysis. Three rounds of consultation were conducted sequentially among a total sample of 44 experienced experts in childhood obesity intervention. Experts first rated the importance and feasibility of factors and strategies related to program sustainability and then completed a card sorting task to group factors and strategies according to whether the same strategies could address them. Inter-rater agreement was assessed using the Average Deviation index. A go-zone plot was generated to visualize strategy priorities by importance and feasibility. Multidimensional scaling and hierarchical cluster analysis were used to identify clusters of sustainability factors and strategies. The results showed that "matching stakeholders' perceived needs" was rated as the most important factor, and 12 strategies were rated as both highly important and feasible in the go-zone plot. Six clusters of sustainability factors and strategies emerged: (1) alignment and collaboration, (2) workforce engagement, (3) capacity building, (4) resource security, (5) sustainability-focused enhancement, and (6) streamlining and optimization. This assessment and categorization of factors and strategies can help practitioners prioritize practices based on their specific needs and contextual conditions to sustain childhood obesity prevention programs. CI - (c) 2026. Society for Prevention Research. FAU - Pan, Shasha AU - Pan S AD - School of Public Health, Shandong Medical and Pharmaceutical University, No. 318 Gangcheng East Road, Laishan District, Yantai, Shandong, China. AD - Department of Medical Insurance and Price Management, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, 310022, China. AD - School of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, 215123, China. FAU - Zhang, Youjie AU - Zhang Y AUID- ORCID: 0000-0003-4319-9809 AD - School of Public Health, Shandong Medical and Pharmaceutical University, No. 318 Gangcheng East Road, Laishan District, Yantai, Shandong, China. ujzhang@sdmpu.edu.cn. LA - eng GR - 82204068/National Natural Science Foundation of China/ PT - Journal Article DEP - 20261026 PL - United States TA - Prev Sci JT - Prevention science : the official journal of the Society for Prevention Research JID - 100894724 SB - IM OTO - NOTNLM OT - Childhood obesity prevention OT - Concept mapping OT - Factors OT - Program sustainability OT - Strategies COIS- Declarations. Ethics Approval: Approval was obtained from the ethics committee of Suzhou Medical College of Soochow University. This study was conducted in accordance with the Declaration of Helsinki. Consent to Participate: All participants consented to the study procedure. Conflict of Interest: The authors declare no competing interests. Clinical Trial Registration: Not applicable. EDAT- 2026/10/26 05:30 MHDA- 2026/10/26 05:30 CRDT- 2026/10/26 00:27 PHST- 2025/12/12 00:00 [received] PHST- 2026/10/13 00:00 [accepted] PHST- 2026/10/26 05:30 [medline] PHST- 2026/10/26 05:30 [pubmed] PHST- 2026/10/26 00:27 [entrez] AID - 10.1007/s11121-026-02001-2 [pii] AID - 10.1007/s11121-026-02001-2 [doi] PST - aheadofprint SO - Prev Sci. 2026 Oct 26. doi: 10.1007/s11121-026-02001-2. PMID- 42928301 OWN - NLM STAT- MEDLINE DCOM- 20261026 LR - 20261028 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 23 IP - 1 DP - 2026 Oct 22 TI - Co-producing an assessment instrument for physical activity policies in the early childhood education and care setting. LID - 10.1186/s12966-026-02001-z [doi] LID - 102 AB - BACKGROUND: Despite the importance of physical activity (PA) for the physical, cognitive, and socio-emotional development of children, the effects of public policies on PA outcomes in early childhood education and care have only recently been investigated. As the available evidence is relatively recent, it has not yet been integrated into existing policy assessment tools. To address this gap, this study aimed to develop an instrument to assess the PA-related content of policies in early childhood education and care. METHODS: The instrument was developed through a multi-phase co-production process involving researchers and representatives from state-level health reporting authorities in Germany. Development was guided by a conceptual framework for policy content analysis and comprised three phases: (1) prototype development based on a systematic analysis of all 16 German educational framework plans, a systematic literature review on the effectiveness of public policies promoting PA in early childhood education and care, and a structured search for national and international policy recommendations; (2) expert consultation using a two-round Delphi survey (n = 24 in round 1; n = 26 in round 2), with indicators rated on a 10-point Likert scale and summarized using median scores; and (3) pilot testing in five German federal states to assess feasibility, clarity, and applicability of the instrument. RESULTS: The initial prototype of the assessment instrument comprised 24 indicators. Several revisions throughout the development process resulted in a final version containing 28 indicators across eight thematic domains (e.g., pedagogical concept, education-related objectives, outdoor PA opportunities, indoor PA opportunities). Pilot testing confirmed the instrument's applicability and feasibility within state-level health reporting, and minor refinements were made to improve the clarity and completeness of individual indicators. Time needed to complete the instrument ranged from approximately one to six hours. CONCLUSIONS: This study developed the first instrument specifically designed to assess the PA-related content of early childhood education and care policies. This may support intersectoral collaboration between the health and youth sector, and could inform future decision-making processes. Moreover, future studies may test its applicability in other countries. CI - (c) 2026. The Author(s). FAU - Brandl, Johannes AU - Brandl J AUID- ORCID: 0009-0001-1700-1339 AD - Department of Sport Science and Sport, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Gebbertstrasse 123B, Erlangen, 91058, Germany. FAU - Oberwohrmann, Sylke AU - Oberwohrmann S AD - Senate Department for Higher Education and Research, Health, and Long-Term Care, Berlin, Germany. FAU - Finger, Jonas AU - Finger J AUID- ORCID: 0000-0003-3697-6649 AD - Senate Department for Higher Education and Research, Health, and Long-Term Care, Berlin, Germany. FAU - Till, Maike AU - Till M AUID- ORCID: 0000-0002-9915-7512 AD - Department of Sport Science and Sport, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Gebbertstrasse 123B, Erlangen, 91058, Germany. FAU - Do, Stefanie AU - Do S AUID- ORCID: 0000-0002-7673-1809 AD - Leibniz-Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Gelius, Peter AU - Gelius P AUID- ORCID: 0000-0002-4120-4996 AD - Institute of Sport Sciences, University of Lausanne, Lausanne, Switzerland. FAU - Hebestreit, Antje AU - Hebestreit A AUID- ORCID: 0000-0001-7354-5958 AD - Leibniz-Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Messing, Sven AU - Messing S AUID- ORCID: 0000-0002-9645-4079 AD - Department of Sport Science and Sport, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Gebbertstrasse 123B, Erlangen, 91058, Germany. sven.messing@fau.de. AD - Physical Activity for Health Research Centre, Health Research Institute, Department of Physical Education and Sport Science, University of Limerick, Limerick, Ireland. sven.messing@fau.de. LA - eng PT - Journal Article DEP - 20261022 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - Germany MH - Child, Preschool MH - *Health Policy MH - *Health Promotion MH - Delphi Technique MH - *Exercise MH - *Child Day Care Centers PMC - PMC13700408 OTO - NOTNLM OT - Childcare OT - Co-production OT - Kindergarten OT - Physical activity OT - Policy assessment OT - Policy evaluation OT - Preschool OT - Tool development COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/26 05:30 MHDA- 2026/10/26 05:31 PMCR- 2026/10/22 CRDT- 2026/10/26 00:25 PHST- 2026/04/09 00:00 [received] PHST- 2026/10/17 00:00 [accepted] PHST- 2026/10/26 05:31 [medline] PHST- 2026/10/26 05:30 [pubmed] PHST- 2026/10/26 00:25 [entrez] PHST- 2026/10/22 00:00 [pmc-release] AID - 10.1186/s12966-026-02001-z [pii] AID - 2001 [pii] AID - 10.1186/s12966-026-02001-z [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2026 Oct 22;23(1):102. doi: 10.1186/s12966-026-02001-z. PMID- 42927982 OWN - NLM STAT- MEDLINE DCOM- 20261025 LR - 20261025 IS - 1475-2727 (Electronic) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Oct 26 TI - Prevalence of food insecurity in households with children under 5 years of age in Ecuador: analysis of the national child malnutrition surveys. PG - e203 LID - 10.1017/S1368980026103541 [doi] AB - OBJECTIVE: To estimate the national prevalence and distribution of food insecurity (FI) among households with children younger than 5 years in Ecuador and to evaluate the psychometric properties of the Food Insecurity Experience Scale (FIES) using two consecutive nationally representative surveys. DESIGN: This cross-sectional study employed descriptive statistics and Tobit regression models using STATA v17. SETTING: We used secondary data from the National Survey on Child Malnutrition in Ecuador, including food security (FS) information for 2022-2023 and 2023-2024, to construct the prevalence time series. PARTICIPANTS: We analysed data from 19 187 households (22 260 children) surveyed in the first round and 20 186 households (23 187 children) surveyed in the second round. RESULTS: FIES showed adequate reliability in both rounds (Rasch reliability 0.80 and 0.79). Seven of eight FIES items showed significant reductions between rounds. The prevalence of moderate-or-severe FI remained high, decreasing from 40.79 % in 2022-2023 to 39.18 % in 2023-2024 (p = 0.239). Severe FI declined significantly from 4.83 % to 3.52 % (p = 0.002). In both rounds, FI was more prevalent in rural areas, the Amazon region, priority territories, Indigenous and Afro-descendant populations and households experiencing poverty or unmet basic needs. In 2023-2024, FI was associated with priority area residence, Indigenous ethnicity, poverty due to unmet basic needs, older child age groups and stunting. CONCLUSIONS: Despite reductions in severe FI, nearly four in ten households with young children in Ecuador continue to experience moderate-or-severe FI, with persistent territorial, ethnic and socio-economic inequalities. Integrated policies linking FS, child nutrition and poverty reduction are needed. FAU - Morejon-Teran, Yadira Alejandra AU - Morejon-Teran YA AUID- ORCID: 0000-0003-2830-3081 AD - Programa de Pos-Graduacao em Saude Coletiva, Instituto de Saude Coletiva, Universidade Federal da Bahia, Salvador, Brasil. ROR: https://ror.org/03k3p7647 AD - Centro de Investigacion en Salud Publica y Epidemiologia Clinica (CISPEC), Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Quito, Ecuador. ROR: https://ror.org/00dmdt028 FAU - Duran-Aguero, Samuel AU - Duran-Aguero S AD - Facultad de Ciencias de la Rehabilitacion y Calidad de Vida, Universidad San Sebastian, Chile. FAU - Rios-Castillo, Israel AU - Rios-Castillo I AD - Organizacion de las Naciones Unidas para la Alimentacion y la Agricultura, Oficina Subregional de la FAO en Mesoamerica, Panama. AD - Escuela de Nutricion y Dietetica, Facultad de Medicina, Universidad de Panama, Panama, Panama. FAU - Alvim Matos, Sheila Maria AU - Alvim Matos SM AD - Instituto de Saude Coletiva, Universidade Federal da Bahia, Brazil. FAU - Rosero Mora, Gabriela AU - Rosero Mora G AD - FAO Ecuador, Food and Agriculture Organization of the United Nations (FAO), Ecuador. LA - eng PT - Journal Article DEP - 20261026 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Ecuador/epidemiology MH - *Food Insecurity MH - Child, Preschool MH - Cross-Sectional Studies MH - *Family Characteristics MH - Prevalence MH - Female MH - Infant MH - Male MH - *Child Nutrition Disorders/epidemiology MH - *Food Supply/statistics & numerical data MH - Nutrition Surveys MH - Socioeconomic Factors MH - Poverty MH - Psychometrics MH - Reproducibility of Results OTO - NOTNLM OT - children OT - food insecurity OT - food insecurity experience scale OT - malnutrition EDAT- 2026/10/25 23:29 MHDA- 2026/10/25 23:30 CRDT- 2026/10/25 21:53 PHST- 2026/10/25 23:30 [medline] PHST- 2026/10/25 23:29 [pubmed] PHST- 2026/10/25 21:53 [entrez] AID - S1368980026103541 [pii] AID - 10.1017/S1368980026103541 [doi] PST - epublish SO - Public Health Nutr. 2026 Oct 26;29(1):e203. doi: 10.1017/S1368980026103541. PMID- 42927569 OWN - NLM STAT- MEDLINE DCOM- 20261025 LR - 20261027 IS - 1436-6215 (Electronic) IS - 1436-6207 (Linking) VI - 65 IP - 8 DP - 2026 Oct 25 TI - Maternal fruit and vegetable consumption in relation to newborn anthropometric outcomes. LID - 285 [pii] LID - 10.1007/s00394-026-04136-y [doi] AB - PURPOSE: To investigate the associations between maternal consumption of fresh fruits, vegetables, and fruit juices during pregnancy and neonatal anthropometric outcomes, including birth weight, birth length and head circumference. METHODS: A prospective cohort study was conducted, including 614 mother-child pairs. Maternal diet was assessed as the average intake across the three trimesters using a validated food frequency questionnaire. Neonatal outcomes were assessed using INTERGROWTH-21st standards as continuous (z-scores) and categorical (below the 10th percentile [< P10]) measures of birth weight, birth length, and head circumference. Associations were estimated using multivariable linear and logistic regression models adjusted for relevant covariates. RESULTS: Each 100 g/day increase in combined consumption of fresh fruits and vegetables during pregnancy was associated with higher birth weight z-score (beta = 0.14 [0.01, 0.27]) and lower odds of birth weight < P10 (OR = 0.62 [0.41, 0.96]) and birth length < P10 (OR = 0.64 [0.42, 0.98]). Separately, each 100 g/day increase in vegetable consumption was associated with lower odds of birth weight < P10, whereas higher fresh fruit consumption was associated with lower odds of birth length < P10. No significant associations were observed for fruit juice consumption, and none of the dietary exposures were associated with head circumference outcomes. CONCLUSION: This study provides new evidence on maternal fresh fruit and vegetable consumption in relation to neonatal anthropometric outcomes by evaluating their overall combined intake alongside their separate consumption. These findings may help strengthen the evidence base for maternal nutritional guidance. CI - (c) 2026. Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Riggioni-Saborio, Lucia AU - Riggioni-Saborio L AUID- ORCID: 0009-0004-9880-7159 AD - Departament de Ciencies Mediques Basiques, Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Universitat Rovira i Virgili, C/Sant Llorenc 21, Reus, 43201, Spain. FAU - Jardi, Cristina AU - Jardi C AUID- ORCID: 0000-0002-7946-1488 AD - Departament de Ciencies Mediques Basiques, Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Universitat Rovira i Virgili, C/Sant Llorenc 21, Reus, 43201, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRB Catsud), Tarragona, 43005, Spain. FAU - Cruz-Rodriguez, Josue AU - Cruz-Rodriguez J AUID- ORCID: 0000-0001-7145-5836 AD - Departament de Ciencies Mediques Basiques, Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Universitat Rovira i Virgili, C/Sant Llorenc 21, Reus, 43201, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRB Catsud), Tarragona, 43005, Spain. FAU - Becerra-Tomas, Nerea AU - Becerra-Tomas N AUID- ORCID: 0000-0002-4429-6507 AD - Departament de Ciencies Mediques Basiques, Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Universitat Rovira i Virgili, C/Sant Llorenc 21, Reus, 43201, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRB Catsud), Tarragona, 43005, Spain. FAU - Arija, Victoria AU - Arija V AD - Departament de Ciencies Mediques Basiques, Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Universitat Rovira i Virgili, C/Sant Llorenc 21, Reus, 43201, Spain. victoria.arija@urv.cat. AD - Institut de Recerca Biomedica Catalunya Sud (IRB Catsud), Tarragona, 43005, Spain. victoria.arija@urv.cat. AD - Collaborative Group on Lifestyles, Nutrition, and Tobacco (CENIT), Institut Catala de La Salut (ICS), Institut D'Investigacio en Atencio Primaria IDIAP Jordi Gol, Reus, Spain. victoria.arija@urv.cat. AD - Institut D'Investigacio en Atencio Primaria IDIAP Jordi Gol, Institut Catala de La Salut (ICS), Barcelona, Spain. victoria.arija@urv.cat. AD - University Research Institute on Sustainability, Climate Change and Energy Transition (IU- RESCAT), Universitat Rovira i Virgili, Tarragona, 43003, Spain. victoria.arija@urv.cat. LA - eng PT - Journal Article DEP - 20261025 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 SB - IM MH - Humans MH - Female MH - *Fruit MH - *Vegetables MH - Pregnancy MH - Prospective Studies MH - Infant, Newborn MH - *Birth Weight MH - *Maternal Nutritional Physiological Phenomena MH - *Diet/methods/statistics & numerical data MH - Adult MH - Anthropometry MH - Fruit and Vegetable Juices MH - Male OTO - NOTNLM OT - Fetal growth OT - Fruit consumption OT - Fruit juice OT - Maternal nutrition OT - Pregnancy OT - Vegetable consumption COIS- Declarations. Conflict of interest: The authors declare no conflict of interest. Consent to participate: All participants signed an informed consent form. Ethical approval: This study was approved by the Clinical Research Ethics Committee of the Jordi Gol Institute for Primary Care Research (IDIAP) and the Pere Virgili Institute for Health Research (IISPV). This study complies with the tenets of the Declaration of Helsinki. EDAT- 2026/10/25 17:31 MHDA- 2026/10/25 17:32 CRDT- 2026/10/25 12:08 PHST- 2026/07/08 00:00 [received] PHST- 2026/10/13 00:00 [accepted] PHST- 2026/10/25 17:32 [medline] PHST- 2026/10/25 17:31 [pubmed] PHST- 2026/10/25 12:08 [entrez] AID - 10.1007/s00394-026-04136-y [pii] AID - 10.1007/s00394-026-04136-y [doi] PST - epublish SO - Eur J Nutr. 2026 Oct 25;65(8):285. doi: 10.1007/s00394-026-04136-y. PMID- 42927166 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261025 LR - 20261026 IS - 2214-7500 (Electronic) IS - 2214-7500 (Linking) VI - 17 DP - 2026 Dec TI - Multi-tissue accumulation of potentially toxic elements and age-stratified non-carcinogenic dietary risk in fish from the Anzali Wetland, Caspian Basin. PG - 102355 LID - 10.1016/j.toxrep.2026.102355 [doi] LID - 102355 AB - Potentially toxic elements (PTEs) in wetland fish are relevant to both environmental monitoring and dietary-exposure assessment, yet studies integrating multi-tissue accumulation with age-stratified health-risk estimates remain limited. This study quantified Al, Ba, Cu, Fe, Ni, and Zn in muscle, gill, visceral, and egg tissues of 48 fish representing northern pike (Esox lucius), common carp (Cyprinus carpio), vimba bream (Vimba vimba), and tench (Tinca tinca) from the Anzali Wetland, Iran. Element concentrations were determined using ICP-MS. Species- and tissue-related differences were evaluated using split-plot repeated-measures analysis, with structure-preserving permutation tests applied to the observed concentration data as a robustness assessment. Inter-element associations were evaluated at the independent biological-replicate level. Significant speciesxtissue interactions were detected for Al, Ba, Cu, Fe, and Zn, indicating that tissue-specific accumulation patterns differed among fish species. Ni showed a significant species effect but no significant tissue effect or species x tissue interaction. Northern pike exhibited comparatively high concentrations of Al, Fe, Ni, and Zn, whereas the most pronounced Ba accumulation occurred in vimba bream gills. After false-discovery-rate correction, significant associations were identified between Al and Fe, Cu and Ni, and Ni and Zn. Dietary exposure and non-carcinogenic risk were estimated for children, adolescents, and adults using wet-weight concentrations measured exclusively in edible muscle tissue. All estimated daily intakes remained below the selected oral toxicity benchmarks, and all individual target hazard quotients and cumulative hazard indices remained below 1. Children consistently showed the highest non-carcinogenic risk estimates. Quantitative carcinogenic risk was not assessed because the investigated elements were evaluated using non-carcinogenic oral toxicity benchmarks and validated oral cancer slope factors applicable to the measured dietary forms, particularly total Ni, were not available within the adopted assessment framework. Overall, the findings demonstrate that multi-tissue elemental accumulation and dietary exposure should be interpreted separately and indicate that appreciable non-carcinogenic effects are unlikely under the assessed muscle-consumption scenarios. CI - (c) 2026 The Authors. FAU - Salehi, Fatemeh AU - Salehi F AD - Department of Environmental Science and Engineering, Arak University, Arak, 384817758, Iran. FAU - Sharafi, Saeed AU - Sharafi S AD - Department of Environmental Science and Engineering, Arak University, Arak, 384817758, Iran. FAU - Kazemi, Ali AU - Kazemi A AD - Department of Environmental Science and Engineering, Arak University, Arak, 384817758, Iran. FAU - Esmaeilbeigi, Milad AU - Esmaeilbeigi M AD - Centre for Applied Water Science, Institute for Applied Ecology, University of Canberra, Canberra, ACT, Australia. FAU - Rahmati, Moein AU - Rahmati M AD - Department of Environmental Science and Engineering, Arak University, Arak, 384817758, Iran. LA - eng PT - Journal Article DEP - 20261013 PL - Ireland TA - Toxicol Rep JT - Toxicology reports JID - 101630272 PMC - PMC13694760 OTO - NOTNLM OT - Anzali wetland OT - Dietary exposure OT - Freshwater fish OT - Hazard index OT - Multi-tissue accumulation OT - Potentially toxic elements COIS- The authors declare no competing interests.The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/25 11:32 MHDA- 2026/10/25 11:33 PMCR- 2026/10/13 CRDT- 2026/10/25 05:05 PHST- 2026/08/13 00:00 [received] PHST- 2026/10/03 00:00 [revised] PHST- 2026/10/06 00:00 [accepted] PHST- 2026/10/25 11:33 [medline] PHST- 2026/10/25 11:32 [pubmed] PHST- 2026/10/25 05:05 [entrez] PHST- 2026/10/13 00:00 [pmc-release] AID - S2214-7500(26)00157-5 [pii] AID - 102355 [pii] AID - 10.1016/j.toxrep.2026.102355 [doi] PST - epublish SO - Toxicol Rep. 2026 Oct 13;17:102355. doi: 10.1016/j.toxrep.2026.102355. eCollection 2026 Dec. PMID- 42926939 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261025 LR - 20261026 IS - 3050-7081 (Electronic) IS - 3050-7081 (Linking) VI - 2 IP - 4 DP - 2026 Dec TI - 'Let's work alongside it': healthcare professionals' perspectives of generative AI in supporting care at home in paediatric rheumatology. PG - 100258 LID - 10.1016/j.ero.2026.100258 [doi] LID - 100258 AB - OBJECTIVES: Generative artificial intelligence (GenAI) is increasingly explored in healthcare, yet its potential to support care at home remains largely unexamined. In paediatric rheumatology, where families frequently undertake complex tasks to manage treatment plans between appointments, safe and effective guidance is essential. The aim of the current study was to understand healthcare professionals' (HCPs') views on adopting GenAI tools to help families manage their child's care. METHODS: Utilising a vignette-based methodology, paediatric rheumatology HCPs were invited to focus groups and presented with 3 hypothetical scenarios: (1) injection administration, (2) flare assessment, and (3) physiotherapy exercises. Following the principles outlined by Braun and Clarke, data were analysed using thematic analysis. RESULTS: A total of 37 HCPs from the wider multidisciplinary team from 14 different hospitals participated in this study. Six main themes were identified: (1) opportunities of GenAI to benefit patient care; (2) disadvantages and challenges; (3) risks, safety netting, and evaluation; (4) different approaches of utilising GenAI; (5) role of HCPs in the world of GenAI; and (6) ensuring inclusivity and accessibility. CONCLUSIONS: HCPs recognised opportunities for how GenAI could support caregivers in managing their child's healthcare or young people's self-management, particularly through guidance support rather than clinical interpretation. However, concerns were raised regarding the accuracy, reliability, privacy, and data governance of currently existing GenAI tools. The perspectives of HCPs are critical to ensuring that the application of GenAI in healthcare aligns with clinical expectations, ethical standards, regulatory processes, and the needs of patients and families. CI - Crown Copyright (c) 2026 Published by Elsevier B.V. on behalf of European Alliance of Associations for Rheumatology (EULAR). FAU - Kupiec, Klaudia H AU - Kupiec KH AD - Department of Paediatric Rheumatology, Great Ormond Street Hospital National Health Service (NHS) Foundation Trust, London, UK. AD - University College London (UCL) Great Ormond Street Institute of Child Health, Infection, Immunity, and Inflammation Research and Teaching Department, University College London, London, UK. AD - National Institute for Health and Care Research (NIHR) Great Ormond Street Hospital Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK. FAU - Sweet, Sabina AU - Sweet S AD - UCL Interaction Centre, Department of Computer Science and Division of Psychology and Language Sciences, University College London, London, UK. FAU - Compeyrot-Lacassagne, Sandrine AU - Compeyrot-Lacassagne S AD - Department of Paediatric Rheumatology, Great Ormond Street Hospital National Health Service (NHS) Foundation Trust, London, UK. AD - University College London (UCL) Great Ormond Street Institute of Child Health, Infection, Immunity, and Inflammation Research and Teaching Department, University College London, London, UK. AD - National Institute for Health and Care Research (NIHR) Great Ormond Street Hospital Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK. FAU - Livermore, Polly AU - Livermore P AD - Department of Paediatric Rheumatology, Great Ormond Street Hospital National Health Service (NHS) Foundation Trust, London, UK. AD - University College London (UCL) Great Ormond Street Institute of Child Health, Infection, Immunity, and Inflammation Research and Teaching Department, University College London, London, UK. AD - National Institute for Health and Care Research (NIHR) Great Ormond Street Hospital Biomedical Research Centre, UCL Great Ormond Street Institute of Child Health, London, UK. LA - eng PT - Journal Article DEP - 20261019 PL - Netherlands TA - EULAR Rheumatol Open JT - EULAR rheumatology open JID - 9919228057406676 PMC - PMC13695108 COIS- All authors meet the journal's criteria for authorship, and none of the authors has any conflict of interest to declare. PL is currently receiving a personal fellowship award from the National Institute for Health and Care Research (NIHR) fellowship for nonmedical healthcare professionals (ACAF reference number 302864), and as PPIE co-lead for the NIHR GOSH BRC, she receives some salary support from the NIHR Biomedical Research Centre at GOSH. PL is also a Senior Centre Affiliate at The Centre for Adolescent Rheumatology Versus Arthritis at UCL, UCLH and GOSH, which is supported by Versus Arthritis (21593). All research at Great Ormond Street Hospital NHS Foundation Trust and UCL Great Ormond Street Institute of Child Health is made possible by the NIHR Great Ormond Street Hospital Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health. EDAT- 2026/10/25 05:37 MHDA- 2026/10/25 05:38 PMCR- 2026/10/19 CRDT- 2026/10/25 04:55 PHST- 2026/10/25 05:38 [medline] PHST- 2026/10/25 05:37 [pubmed] PHST- 2026/10/25 04:55 [entrez] PHST- 2026/10/19 00:00 [pmc-release] AID - S3050-7081(26)00157-6 [pii] AID - 100258 [pii] AID - 10.1016/j.ero.2026.100258 [doi] PST - epublish SO - EULAR Rheumatol Open. 2026 Oct 19;2(4):100258. doi: 10.1016/j.ero.2026.100258. eCollection 2026 Dec. PMID- 42926197 OWN - NLM STAT- Publisher LR - 20261025 IS - 1476-5497 (Electronic) IS - 0307-0565 (Linking) DP - 2026 Oct 24 TI - Maternal mid-pregnancy metabolic profiles and growth trajectories across the first 36 months of life in a UK multi-ethnic birth cohort. LID - 10.1038/s41366-026-02233-w [doi] AB - OBJECTIVES: To investigate the influence of maternal mid-pregnancy metabolomic profiles on offspring anthropometric growth trajectories (weight, length/height, and BMI) across the first 36 months of life in a multi-ethnic birth cohort. METHODS: This longitudinal study analyzed 1423 mother-child pairs from the Born in Bradford cohort. Using NMR, 147 metabolites were quantified in maternal fasting blood samples collected at 26-28 weeks of gestation. Children's growth trajectories for weight, length/height, and BMI across 0-36 months of life were modeled using latent class growth mixture models. Partial least squares discriminant analysis identified key maternal metabolites distinguishing growth trajectories, followed by linear mixed-effects regression examining associations with WHO growth z-scores adjusted for a minimal set of covariates (ethnicity and gestational diabetes mellitus, GDM). RESULTS: Three distinct growth trajectories were identified for each anthropometric measure: normative, intermediate, and non-uniform (accelerated for weight and BMI or faltered for length/height). For each growth trajectory, between 30 and 41 metabolites were required to differentiate between trajectories within each anthropometric measure. Fourteen lipoprotein subclasses were required across weight, length/height, and BMI, with an additional 16 to 31 metabolites required in one or two trajectories. Numerous associations between metabolite levels and change in z-score anrthropometric measures were observed and validated within each growth trajectory (-0.47 to 1.5 for weight; -0.87 to 2.2 for height/length; and -0.85 to 1.8 for BMI; P < 0.05) per unit change in metabolite. South Asian ethnicity and GDM were associated with lower z-scores (-0.214 to -0.212 and -0.044 to -0.041 for weight; -0.061 to -0.045 and -0.104 to -0.101 for length/height; and -0.157 to -0.182 and -0.083 to -0.071 for BMI, respectively). CONCLUSIONS: Metabolomic profiles in mid-pregnancy, especially lipoproteins, characterize observed offspring growth in different directions and/or strengths in various growth trajectories from birth to 36 months of age. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Zielinska-Pukos, Monika A AU - Zielinska-Pukos MA AUID- ORCID: 0000-0001-8894-6746 AD - Food, Nutrition, and Health, University of British Columbia, Vancouver, BC, Canada. monika_zielinska_pukos@sggw.edu.pl. AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW-WULS), Warsaw, Poland. monika_zielinska_pukos@sggw.edu.pl. FAU - Zulyniak, Michael A AU - Zulyniak MA AUID- ORCID: 0000-0003-4944-5521 AD - Food, Nutrition, and Health, University of British Columbia, Vancouver, BC, Canada. michael.zulyniak@ubc.ca. AD - BC Children's and Women's Hospital Health Research Institutes, Vancouver, BC, Canada. michael.zulyniak@ubc.ca. AD - Leeds Institute of Medical Research, University of Leeds, Leeds, UK. michael.zulyniak@ubc.ca. LA - eng PT - Journal Article DEP - 20261024 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/10/25 05:37 MHDA- 2026/10/25 05:37 CRDT- 2026/10/25 00:15 PHST- 2025/12/10 00:00 [received] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/09/04 00:00 [revised] PHST- 2026/10/25 05:37 [medline] PHST- 2026/10/25 05:37 [pubmed] PHST- 2026/10/25 00:15 [entrez] AID - 10.1038/s41366-026-02233-w [pii] AID - 10.1038/s41366-026-02233-w [doi] PST - aheadofprint SO - Int J Obes (Lond). 2026 Oct 24. doi: 10.1038/s41366-026-02233-w. PMID- 42926060 OWN - NLM STAT- Publisher LR - 20261024 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) DP - 2026 Oct 24 TI - Prevalence of Sarcopenic Obesity and Agreement Between Bioelectrical Impedance Analysis and Dual-Energy X-ray Absorptiometry in Children with Idiopathic Nephrotic Syndrome: A Cross-Sectional Study. PG - 105206 LID - S2405-4577(26)02303-X [pii] LID - 10.1016/j.clnesp.2026.105206 [doi] AB - BACKGROUND AND AIMS: Sarcopenic obesity (SO) is an increasingly recognised nutritional complication of chronic paediatric disease. Children with idiopathic nephrotic syndrome (INS) are predisposed to adverse body composition changes from persistent proteinuria, relapses, and corticosteroid exposure, but the prevalence of SO in this population is unknown. We aimed to determine SO prevalence, characterise body composition and bone health by SO status, and assess agreement between bioelectrical impedance analysis (BIA) and dual-energy X-ray absorptiometry (DXA) in children with INS. METHODS: This cross-sectional study enrolled 128 children aged 3-16 years with INS in complete remission. Sarcopenia was defined as fat-free mass index below the 25th percentile (Indian reference standards); obesity was defined by BMI and by DXA-derived fat mass index above the 99th percentile. SO was therefore defined on body composition criteria alone, without functional muscle assessment, and is referred to as body composition-defined SO. All participants underwent simultaneous DXA and BIA. Agreement was assessed using intraclass correlation coefficient, Bland-Altman analysis with formal testing for proportional bias, and Cohen's kappa, with Pearson correlation reported descriptively. Because the Indian reference datasets do not span the full age range enrolled, the primary analysis was repeated in the subgroup covered by both references (6.0-15.0 years, n = 92). RESULTS: Sarcopenia was present in 46.9% (60/128) and obesity in 14.1% (BMI) versus 43.0% (DXA). SO occurred in 17.2% (22/128; 95% CI 10.6-23.8) by DXA criteria; no child met BMI-based SO criteria. In the subgroup covered by both reference datasets, SO prevalence was 13.0% (12/92; 95% CI 6.2-19.9). Children with SO were younger, with shorter disease duration, fewer relapses, and lower corticosteroid dose, and had lower whole-body BMC and BMD (both p < 0.001) despite comparable BMD Z-scores; these absolute bone differences did not persist after adjustment for age and height. BIA correlated strongly with DXA for fat-free mass (r = 0.964) and fat mass (r = 0.943) but systematically underestimated fat mass (mean bias -3.38 kg) and body fat percentage (-11.24%) and overestimated fat-free mass (+2.75 kg), with significant proportional bias for every compartment (all p < 0.001) and 0% sensitivity for DXA-confirmed SO (0/22; 95% CI 0.0-15.4). CONCLUSIONS: Body composition-defined SO affected roughly one in six children with INS in remission and was not detected by BMI. Within this cohort, across device and operational thresholds, BIA ranked continuous body composition well but did not reproduce the DXA-based SO classification. These estimates apply to body composition-defined SO and require confirmation in longitudinal, multicentre cohorts incorporating muscle function testing. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Punia, Simran AU - Punia S AD - Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India - 160012. Electronic address: simranpunia2226@gmail.com. FAU - Dawman, Lesa AU - Dawman L AD - Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India - 160012. Electronic address: lesadawman@gmail.com. FAU - Kaur, Harvinder AU - Kaur H AD - Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India - 160012. Electronic address: harvinderkaur315@gmail.com. FAU - Singh, Tulika AU - Singh T AD - Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, India - 160012. Electronic address: tulikardx@gmail.com. FAU - Yadav, Jaivinder AU - Yadav J AD - Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India - 160012. Electronic address: jai1984yadav@gmail.com. FAU - Vallabhaneni, Pujitha AU - Vallabhaneni P AD - Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India - 160012. Electronic address: vallabhanenipujitha143@gmail.com. FAU - Sadasivam, Deepthika AU - Sadasivam D AD - Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India - 160012. Electronic address: ss.deepthika@gmail.com. FAU - Mahajan, Shailza AU - Mahajan S AD - Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India - 160012. Electronic address: drshailzamahajan35@gmail.com. FAU - Tiewsoh, Karalanglin AU - Tiewsoh K AD - Department of Pediatrics, Advanced Pediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India - 160012. Electronic address: ktiewsoh@rediffmail.com. LA - eng PT - Journal Article DEP - 20261024 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM OTO - NOTNLM OT - Bioelectrical impedance analysis OT - body composition OT - dual-energy X-ray absorptiometry OT - idiopathic nephrotic syndrome OT - paediatric OT - sarcopenic obesity EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:36 CRDT- 2026/10/24 19:30 PHST- 2026/06/28 00:00 [received] PHST- 2026/10/02 00:00 [revised] PHST- 2026/10/18 00:00 [accepted] PHST- 2026/10/25 03:36 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 19:30 [entrez] AID - S2405-4577(26)02303-X [pii] AID - 10.1016/j.clnesp.2026.105206 [doi] PST - aheadofprint SO - Clin Nutr ESPEN. 2026 Oct 24:105206. doi: 10.1016/j.clnesp.2026.105206. PMID- 42925329 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261027 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 11 DP - 2026 Oct 24 TI - Serum Netrin-1 and ultrasonographic hepatic steatosis severity in obese children and adolescents with metabolic dysfunction-associated steatotic liver disease: a preliminary study. LID - 887 [pii] LID - 10.1007/s00431-026-07566-2 [doi] AB - Metabolic dysfunction-associated steatotic liver disease (MASLD) is a frequent hepatic complication of pediatric obesity, yet non-invasive circulating biomarkers associated with ultrasonographic steatosis severity remain limited. Netrin-1 is an immunometabolic regulator implicated in obesity-related inflammation and lipid metabolism, but prospective pediatric data in MASLD are scarce. In this preliminary prospective case-control study, 44 children and adolescents with obesity-related MASLD and 44 age- and sex-matched healthy controls with normal BMI were enrolled. Hepatic steatosis was assessed by ultrasonography, and serum Netrin-1 concentrations were measured by ELISA. Associations with ultrasonographic steatosis grade were evaluated using regression analyses, and discriminatory performance for moderate-to-severe ultrasonographic steatosis, defined as grades 2-3, was explored by receiver operating characteristic (ROC) analysis. Serum Netrin-1 concentrations were significantly higher in children and adolescents with obesity-related MASLD than in healthy controls with normal BMI (633.9 vs 302.0 pg/mL; p < 0.001). Within the MASLD group, Netrin-1 concentrations were higher in participants with grade 2-3 steatosis than in those with grade 1 steatosis (828.9 vs 594.7 pg/mL; p < 0.001). Netrin-1 correlated positively with alanine aminotransferase (rho = 0.669; p < 0.001). ROC analysis showed good discriminatory performance for moderate-to-severe ultrasonographic steatosis (AUC 0.827; 95% CI 0.699-0.955). CONCLUSION: These preliminary findings suggest that serum Netrin-1 may represent an exploratory complementary biomarker candidate associated with ultrasonographic steatosis severity in pediatric MASLD. Larger multicenter studies including children and adolescents with obesity but without steatosis, together with quantitative imaging-based assessment, are required to validate these associations and determine the incremental clinical value of serum Netrin-1. WHAT IS KNOWN: * Pediatric MASLD lacks validated non-invasive circulating biomarkers for assessing hepatic steatosis severity. * Netrin-1 is an immunometabolic mediator implicated in obesity-related inflammation and lipid metabolism, but pediatric data in MASLD are scarce. WHAT IS NEW: * In this preliminary prospective case-control study, serum Netrin-1 concentrations were higher in children and adolescents with obesity-related MASLD and were higher in those with grade 2-3 ultrasonographic steatosis than in those with grade 1 steatosis. * Serum Netrin-1 showed good exploratory discriminatory performance for moderate-to-severe ultrasonographic steatosis, suggesting that it may represent a complementary biomarker candidate requiring validation in larger independent pediatric cohorts. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Ozyilmaz, Leyla Gizem Bolac AU - Ozyilmaz LGB AUID- ORCID: 0000-0001-9056-080X AD - Department of Pediatric Endocrinology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey. gizembolac@gmail.com. FAU - Inan, Ertugrul AU - Inan E AUID- ORCID: 0000-0001-5802-0467 AD - Department of Pediatric Endocrinology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey. FAU - Ozdemir Akgun, Sevgi AU - Ozdemir Akgun S AUID- ORCID: 0000-0002-3053-8261 AD - Department of Pediatric Endocrinology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey. FAU - Ozyilmaz, Safa AU - Ozyilmaz S AUID- ORCID: 0009-0002-2041-1037 AD - Department of Radiology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Cakir, Aydilek Dagdeviren AU - Cakir AD AUID- ORCID: 0000-0001-7136-9241 AD - Department of Pediatric Endocrinology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey. FAU - Ucar, Ahmet AU - Ucar A AUID- ORCID: 0000-0001-8144-8437 AD - Department of Pediatric Endocrinology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20261024 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 158651-98-0 (Netrin-1) RN - 0 (Biomarkers) RN - 0 (NTN1 protein, human) SB - IM MH - Humans MH - *Netrin-1/blood MH - Male MH - Female MH - Adolescent MH - Child MH - Prospective Studies MH - Case-Control Studies MH - Biomarkers/blood MH - Ultrasonography MH - Severity of Illness Index MH - *Fatty Liver/blood/diagnostic imaging/etiology MH - *Pediatric Obesity/complications/blood MH - ROC Curve MH - Enzyme-Linked Immunosorbent Assay MH - *Non-alcoholic Fatty Liver Disease/blood/diagnostic imaging/etiology OTO - NOTNLM OT - Adolescents OT - Biomarkers OT - Children OT - Hepatic steatosis OT - MASLD OT - Netrin-1 COIS- Declarations. Ethical approval: This study protocol was reviewed and approved by the Institutional Ethics Committee of the University of Health Sciences Hamidiye Etfal Training and Research Hospital (Istanbul, Turkey), approval number 4158 (November 7, 2023). The study was conducted in accordance with the principles of the Declaration of Helsinki and its later amendments. Written informed consent was obtained from the parents or legal guardians of all participants before study enrollment. In addition, written assent was obtained from children aged 12 years and older, in accordance with institutional ethical requirements. Consent to participate: Written informed consent to participate in the study was obtained from the parents or legal guardians of all participants. In addition, written assent was obtained from children aged 12 years and older, in accordance with institutional and ethical guidelines. Conflict of interest: The authors declare no competing interests. EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 CRDT- 2026/10/24 12:34 PHST- 2026/07/01 00:00 [received] PHST- 2026/10/20 00:00 [accepted] PHST- 2026/08/03 00:00 [revised] PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 12:34 [entrez] AID - 10.1007/s00431-026-07566-2 [pii] AID - 10.1007/s00431-026-07566-2 [doi] PST - epublish SO - Eur J Pediatr. 2026 Oct 24;185(11):887. doi: 10.1007/s00431-026-07566-2. PMID- 42925112 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261024 IS - 2531-0437 (Electronic) IS - 2531-0429 (Linking) VI - 32 IP - 1 DP - 2026 Dec TI - Six-minute walk distance reference values using a 15-metre course: A pragmatic study for resource-constrained settings. PG - 2751770 LID - 10.1080/25310429.2026.2751770 [doi] AB - BACKGROUND: The six-minute walk test (6MWT) is a simple, widely used measure of functional exercise capacity in children. Standard protocols recommend a 30-meter walking course; however, this is often impractical in routine clinical settings, particularly in resource-limited environments. Normative data for Indian children, especially younger age groups and under pragmatic testing conditions, remain limited. OBJECTIVES: To establish age- and sex-specific reference values for six-minute walk distance (6MWD) in apparently healthy Indian children aged 4-14 years using a pragmatic 15-meter walking course and evaluate associations with anthropometric variables. METHODS: In this community-based cross-sectional study, 400 healthy school-going children underwent the 6MWT using a standardized 15-meter indoor course. Anthropometric and baseline physiological parameters were recorded. Percentile reference values were generated, and multivariable linear regression was performed to identify determinants of 6MWD and derive a predictive equation. RESULTS: Mean (SD) 6MWD was 365.3 (50.8) meters. Distance increased significantly with age, height, weight, and body mass index (all p<0.001). After adjustment, no independent sex-based differences were observed. The predictive equation was: 6MWD = 279.5 + 8.6 x age (years) + 2.7 x weight (kg) - 5.0 x BMI (kg/m(2)) (R(2) = 0.62). No significant differences were observed by residence or school type. CONCLUSIONS: This study provides 15-meter course-specific reference values for 6MWD in healthy Indian children aged 4-14 years. The derived predictive equation may assist interpretation of 6MWD obtained using this protocol; however, external validation and direct comparison with the standard 30-meter course are required before broader application, where longer courses are not feasible. FAU - Jaladi, Harini Chowdary AU - Jaladi HC AD - Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India. FAU - Gulla, Krishna Mohan AU - Gulla KM AUID- ORCID: 0000-0001-5031-5754 AD - Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India. FAU - Das, Rashmi Ranjan AU - Das RR AUID- ORCID: 0000-0001-9587-0508 AD - Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India. FAU - Behera, Binod Kumar AU - Behera BK AUID- ORCID: 0000-0001-8113-5289 AD - Department of Community Medicine & Family Medicine, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India. FAU - Nayak, Saurav AU - Nayak S AUID- ORCID: 0000-0003-2394-295X AD - Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India. FAU - Dwibedi, Bhagirathi AU - Dwibedi B AUID- ORCID: 0000-0002-5318-6836 AD - Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), Bhubaneswar, India. LA - eng PT - Journal Article DEP - 20261023 PL - United States TA - Pulmonology JT - Pulmonology JID - 101723786 SB - IM MH - Humans MH - Child MH - Male MH - Adolescent MH - Reference Values MH - Child, Preschool MH - Cross-Sectional Studies MH - *Walk Test/methods/standards MH - Female MH - India MH - *Walking/physiology MH - *Exercise Tolerance/physiology MH - Age Factors MH - Body Mass Index OTO - NOTNLM OT - Six-minute walk test OT - exercise tolerance OT - field walking test OT - functional exercise capacity OT - paediatric population EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 CRDT- 2026/10/24 12:22 PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 12:22 [entrez] AID - 10.1080/25310429.2026.2751770 [doi] PST - ppublish SO - Pulmonology. 2026 Dec;32(1):2751770. doi: 10.1080/25310429.2026.2751770. Epub 2026 Oct 23. PMID- 42924704 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261024 LR - 20261026 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 11 IP - 4 DP - 2026 Oct 16 TI - Psychometric Properties of the French Version of the Physical Literacy in Children Questionnaire (PL-C Quest). LID - 10.3390/jfmk11040425 [doi] LID - 425 AB - Background and Objectives: The main objective of this study was to examine the psychometric properties of a French adaptation of the Physical Literacy in Children Questionnaire (PL-C Quest). Methods: A sample of 196 French-speaking Canadian and French children (aged 5 to 12 years) participated in this study. Results: Matching the results from several previous studies, our results failed to support the adequacy of the a priori four-factor and hierarchical structure of the PL-C Quest. However, results from an exploratory factor analytic solution supported a 3-factor, 13-item solution of the PL-C Quest measuring (a) Physical Competencies; (b) Motivation and Enjoyment to be Physically Active; and (c) Self-Regulation, Risk, and Safety. Subsequent analyses revealed a lack of differential item functioning (DIF) as function of countries and children's time spent in moderate to vigorous physical activities (MVPA) providing preliminary support for the comparability of scores across these groups. However, some limited evidence of DIF was found as function of children's age (on one item), body mass-index (on two items) and sex (on one item). Furthermore, latent mean differences (favoring younger children and boys) were identified in (a) Self-Regulation, Risk, and Safety and (b) Physical Competencies as function of children's age and sex, respectively. These findings should be interpreted cautiously and warrant replication in independent samples. Finally, results provided preliminary evidence for the convergent validity of the 13-item French version of the PL-C Quest in relation to parental ratings of children's overall, cognitive, and motor physical literacy. Conclusions: Scores on the new 13-item French version of the PL-C Quest present acceptable psychometric properties in terms of composite reliability, factor validity, and minimal DIF, alongside preliminary support for convergent validity. FAU - Maiano, Christophe AU - Maiano C AUID- ORCID: 0000-0002-4764-2209 AD - Department of Psychoeducation and Psychology, Universite du Quebec en Outaouais, Saint-Jerome, QC J7Z 0B7, Canada. AD - Cyberpsychology Laboratory, Department of Psychoeducation and Psychology, Universite du Quebec en Outaouais, Gatineau, QC J8X 3X7, Canada. AD - Substantive-Methodological Synergy Research Laboratory, Department of Psychology, Concordia University, Montreal, QC H4B 1R6, Canada. FAU - Morin, Alexandre J S AU - Morin AJS AUID- ORCID: 0000-0001-6898-4788 AD - Substantive-Methodological Synergy Research Laboratory, Department of Psychology, Concordia University, Montreal, QC H4B 1R6, Canada. AD - Optentia Research Unit, North-West University, P.O. Box 1174, Vanderbijlpark 1900, South Africa. FAU - April, Johanne AU - April J AD - Department of Educational Sciences, Universite du Quebec en Outaouais, Saint-Jerome, QC J7Z 0B7, Canada. FAU - Hue, Olivier AU - Hue O AUID- ORCID: 0000-0001-9270-5291 AD - Department of Physical Activity Sciences, Universite du Quebec a Trois-Rivieres, Trois-Rivieres, QC G9A 5H7, Canada. FAU - Rey, Olivier AU - Rey O AD - Institute of Movement Sciences, Centre National de la Recherche Scientifique, Aix Marseille University, 13288 Marseille Cedex 09, France. LA - eng GR - 633-2022-00060/Social Sciences and Humanities Research Council/ PT - Journal Article DEP - 20261016 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC13692324 OTO - NOTNLM OT - French OT - age OT - body mass index OT - differential item functioning OT - physical activity OT - physical literacy OT - sex COIS- The authors declare no conflicts of interest. EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 PMCR- 2026/10/16 CRDT- 2026/10/24 12:07 PHST- 2026/08/27 00:00 [received] PHST- 2026/09/21 00:00 [revised] PHST- 2026/10/08 00:00 [accepted] PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 12:07 [entrez] PHST- 2026/10/16 00:00 [pmc-release] AID - jfmk11040425 [pii] AID - jfmk-11-00425 [pii] AID - 10.3390/jfmk11040425 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2026 Oct 16;11(4):425. doi: 10.3390/jfmk11040425. PMID- 42924692 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261024 LR - 20261026 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 11 IP - 4 DP - 2026 Oct 8 TI - Musculoskeletal Findings Following Pre-Participation Screening in Young Athletes: A Retrospective Observational Study. LID - 10.3390/jfmk11040413 [doi] LID - 413 AB - Background: Pre-participation screening (PPS) is widely used to evaluate athletes before sport participation, traditionally focusing on cardiovascular risk prevention. However, musculoskeletal assessment performed during PPS may also allow early identification of biomechanical and structural abnormalities that can affect sport participation during growth. Objectives: This study aimed to describe the prevalence, clinical characteristics, and management pathways of musculoskeletal alterations detected during PPS in young athletes, with particular focus on referral patterns to pediatric Physical Medicine and Rehabilitation (PM&R) specialists. Methods: This retrospective observational study included athletes aged /=3 years of experience) were allocated to an experimental group (EG; n = 12) or control group (CG; n = 12). The EG performed a 12-week technology-assisted neuromuscular training program (BlazePod light-sensor system) before each session; the CG continued standard uchi-komi. Three outcome domains were assessed at baseline and post-intervention: (i) judo-specific anaerobic fitness (SJFT); (ii) specific shuttle agility (BlazePod protocol); and (iii) static plantar pressure (BTS P-WALK baropodometer). Results: Retention was 100% with no adverse events. A 2 x 2 mixed-design ANOVA (group x time) showed a significant interaction for BlazePod shuttle agility performance (total hits: p = 0.026; average sprint time: p = 0.009), an effect that remained significant after a sensitivity analysis controlling for baseline anthropometric imbalance between groups. A significant interaction was also observed for the SJFT index (p = 0.028), but this effect did not survive the same sensitivity analysis (p = 0.10). No significant group x time interaction was detected for any of the six static plantar pressure regions assessed (all p > 0.09). Conclusions: In this pilot study, feasibility was supported by 100% retention and the absence of reported adverse events. The data provided preliminary evidence of a group x time interaction for judo-specific shuttle agility performance that remained significant after adjustment for baseline anthropometric imbalance, a less certain interaction for anaerobic fitness, and no detectable interaction for static plantar pressure distribution. These preliminary, hypothesis-generating findings support conducting a definitive, randomized, weight-stratified controlled trial. FAU - Nagy, Alpar AU - Nagy A AD - Doctoral School of Physical Education and Sport, Babes-Bolyai University, 400015 Cluj-Napoca, Romania. AD - "Activ Judo" Sports Club, 405100 Campia Turzii, Romania. FAU - Ordean, Mircea Nicolae AU - Ordean MN AD - Department of Physical Education and Sport, University "1 Decembrie 1918", 510009 Alba Iulia, Romania. FAU - Grosu, Vlad Teodor AU - Grosu VT AUID- ORCID: 0000-0002-4846-4491 AD - Department of Mechatronics and Machine Dynamics, Technical University of Cluj-Napoca, 400114 Cluj-Napoca, Romania. FAU - Mancini, Nicola AU - Mancini N AUID- ORCID: 0009-0005-4566-6417 AD - Department of Education and Sport Sciences, Pegaso Telematic University, 80143 Naples, Italy. FAU - Mancini, Siria AU - Mancini S AUID- ORCID: 0009-0003-5584-6409 AD - Department of Experimental and Clinical Medicine, University of Foggia, 71121 Foggia, Italy. FAU - Neagu, Sonia Gabriela AU - Neagu SG AUID- ORCID: 0009-0000-3064-5537 AD - Faculty of Sciences, Physical Education and Sport, "Lucian Blaga" University of Sibiu, 550012 Sibiu, Romania. FAU - Grosu, Emilia Florina AU - Grosu EF AUID- ORCID: 0000-0002-2846-9586 AD - Doctoral School of Physical Education and Sport, Babes-Bolyai University, 400015 Cluj-Napoca, Romania. FAU - Aducovschi, Daniela AU - Aducovschi D AUID- ORCID: 0000-0001-7178-0786 AD - Department of Physical Education and Sport, University of Bucharest, 010041 Bucharest, Romania. FAU - Sabau, Anca Maria AU - Sabau AM AD - Department of Physical Education, Sport and Physiotherapy, University of Oradea, 410087 Oradea, Romania. FAU - Mihaiu, Costinel AU - Mihaiu C AUID- ORCID: 0009-0007-0897-0780 AD - Department of Physical Education and Sport, University of Bucharest, 010041 Bucharest, Romania. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC13692397 OTO - NOTNLM OT - Special Judo Fitness Test OT - adolescent athletes OT - baropodometry OT - ippon-seoi-nage OT - judo OT - kuzushi OT - neuromuscular training OT - pilot study OT - plantar pressure OT - shuttle agility COIS- The authors declare no conflicts of interest. EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 PMCR- 2026/10/01 CRDT- 2026/10/24 12:07 PHST- 2026/08/19 00:00 [received] PHST- 2026/09/25 00:00 [revised] PHST- 2026/09/27 00:00 [accepted] PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 12:07 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - jfmk11040399 [pii] AID - jfmk-11-00399 [pii] AID - 10.3390/jfmk11040399 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2026 Oct 1;11(4):399. doi: 10.3390/jfmk11040399. PMID- 42923491 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261024 LR - 20261025 IS - 1943-8141 (Print) IS - 1943-8141 (Electronic) IS - 1943-8141 (Linking) VI - 18 IP - 9 DP - 2026 TI - Risk factor for impaired lung function in asthmatic children: predictive value of 25-OH-D, BMI and inflammatory markers. PG - 7799-7809 LID - 10.62347/KKJG5734 [doi] AB - OBJECTIVE: This cross-sectional study investigated the associations between modifiable metabolic risk factors (vitamin D status and obesity) and pulmonary function decline in children with asthma, independent of disease duration and airway inflammation. METHODS: Medical records of 430 asthmatic children (aged /=25 kg/m(2), n = 5). CONCLUSIONS: High retention, adherence, and acceptability suggest TRE in youth with T1D is feasible; however, the low enrollment rate questions feasibility. Low rates of hypoglycemia suggest safety. These findings will inform larger TRE trials in youth with T1D. CI - (c) 2026 by the American Diabetes Association. FAU - Berman, Casey M AU - Berman CM AUID- ORCID: 0000-0003-2045-4213 AD - Children's Hospital Los Angeles, Los Angeles, CA. FAU - Vidmar, Alaina P AU - Vidmar AP AD - Children's Hospital Los Angeles, Los Angeles, CA. AD - Keck School of Medicine, University of Southern California, Los Angeles, CA. FAU - Flores Garcia, Jaquelin AU - Flores Garcia J AD - Children's Hospital Los Angeles, Los Angeles, CA. FAU - Reid, Mark W AU - Reid MW AD - Children's Hospital Los Angeles, Los Angeles, CA. FAU - Gonzalez, Frances AU - Gonzalez F AD - Children's Hospital Los Angeles, Los Angeles, CA. FAU - Torres Sanchez, Alejandra AU - Torres Sanchez A AD - Children's Hospital Los Angeles, Los Angeles, CA. FAU - Salcedo-Rodriguez, Elizabeth AU - Salcedo-Rodriguez E AD - Children's Hospital Los Angeles, Los Angeles, CA. FAU - Raymond, Jennifer K AU - Raymond JK AD - Children's Hospital Los Angeles, Los Angeles, CA. AD - Keck School of Medicine, University of Southern California, Los Angeles, CA. LA - eng PT - Journal Article DEP - 20260915 PL - United States TA - Diabetes Obes Cardiometab CARE JT - Diabetes, obesity, and cardiometabolic CARE JID - 9919229522706676 PMC - PMC13687448 COIS- No potential conflicts of interest relevant to this article were reported. EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 PMCR- 2026/09/15 CRDT- 2026/10/24 10:39 PHST- 2026/01/15 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 10:39 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - 250087 [pii] AID - 10.2337/doc25-0087 [doi] PST - epublish SO - Diabetes Obes Cardiometab CARE. 2026 Sep 15;1(5):849-857. doi: 10.2337/doc25-0087. eCollection 2026 Sep-Oct. PMID- 42923001 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261024 LR - 20261025 IS - 1664-042X (Print) IS - 1664-042X (Electronic) IS - 1664-042X (Linking) VI - 17 DP - 2026 TI - Relationships between physical fitness and early standing-start kinematic characteristics in adolescent male track cyclists. PG - 1948251 LID - 10.3389/fphys.2026.1948251 [doi] LID - 1948251 AB - The early standing-start phase is important for sprint track cycling, yet continuous standing-start kinematics and their relationships with physical fitness remain unclear in adolescent athletes. This study characterized standing-start kinematics, assessed their reliability, and examined their associations with physical fitness in 11 adolescent male track cyclists. Participants completed standing long jump, back squat 1RM, and 30-s cycling sprint tests, followed by three standing-start trials. Continuous trunk and lower-limb kinematics from movement initiation through the first 180 degrees of crank rotation were obtained using markerless motion analysis. The three-trial mean showed high reliability across the six kinematic variables (ICC(A,3) = 0.810-0.965). Relative mean power showed the strongest association with knee range of motion (rho = 0.700, raw p = 0.0165), but none of the 24 associations remained significant after BH-FDR correction. These findings support repeated-trial assessment for reliable characterization of standing-start kinematics and provide preliminary evidence for further investigation of fitness-kinematic relationships in adolescent track cyclists. CI - Copyright (c) 2026 Li, Zhang, Gao, Dong and Guo. FAU - Li, Wei AU - Li W AD - School of Physical Education, Ludong University, Yantai, China. FAU - Zhang, Qian AU - Zhang Q AD - Department of Traffic Engineering, Shandong Transport Vocational College, Weifang, China. FAU - Gao, Qiang AU - Gao Q AD - Yantai Sports Park Management and Service Center, Yantai, China. FAU - Dong, Delong AU - Dong D AD - School of Physical Education, Ludong University, Yantai, China. FAU - Guo, Yuwei AU - Guo Y AD - School of Physical Education, Ludong University, Yantai, China. LA - eng PT - Journal Article DEP - 20261008 PL - Switzerland TA - Front Physiol JT - Frontiers in physiology JID - 101549006 PMC - PMC13686819 OTO - NOTNLM OT - biomechanics OT - continuous kinematics OT - kinematic characteristics OT - physical fitness OT - sprint track cycling OT - standing start COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 PMCR- 2026/10/08 CRDT- 2026/10/24 10:37 PHST- 2026/07/25 00:00 [received] PHST- 2026/09/02 00:00 [revised] PHST- 2026/09/14 00:00 [accepted] PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 10:37 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - 10.3389/fphys.2026.1948251 [doi] PST - epublish SO - Front Physiol. 2026 Oct 8;17:1948251. doi: 10.3389/fphys.2026.1948251. eCollection 2026. PMID- 42922781 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261025 IS - 2237-9622 (Electronic) IS - 1679-4974 (Print) IS - 1679-4974 (Linking) VI - 35 DP - 2026 TI - Performance of anthropometric indices in early detection of diabetes and prediabetes in the Brazilian population: a cross-sectional study, Brazil, 2013. PG - e20240606 LID - 10.1590/S2237-96222026v35e20240606.en [doi] LID - e20240606 AB - OBJECTIVE: To assess the diagnostic performance of anthropometric adiposity metrics for diabetes and prediabetes detection in Brazilian adults. METHODS: This was a cross-sectional study using data from national surveys, such as glycated hemoglobin laboratory test data. Diabetes was defined as glycated hemoglobin >/=6.5% or when hypoglycemic agents were being taken; prediabetes was defined as glycated hemoglobin >/=5.7% and <6.5%. Diabetes and prediabetes prevalence rates were estimated with 95% confidence intervals (95%CI). The diagnostic performance of anthropometric indices - body mass index (BMI), waist circumference (WC), waist-to-height ratio (WHR), and body shape index - were evaluated using the area under the ROC curve (AUC), sensitivity, specificity, positive and negative predictive value, and Youden's index, stratified by sex and age group. RESULTS: 8,435 individuals participated in the study. Diabetes prevalence was 8.6% (95%CI 7.8; 9.3), while prediabetes prevalence was 16.2% (95%CI 15.1; 17.3). In males <40 years old, the AUC for the anthropometric indices was close to 0.5; among males between 40 and 59 years old, it ranged from 0.66 to 0.71; in older males, the AUC for WC was 0.72. Among females <40 years old, the WHR AUC was 0.77; for those between 40 and 59 years old, it ranged from 0.64 to 0.69; and in older females, the WC AUC was 0.66. The AUCs were lower for prediabetes: in males, they ranged from 0.58 to 0.63; while in females they ranged from 0.60 to 0.65. CONCLUSION: WC was the index with the best performance for differentiating individuals with diabetes, while the ROC curve showed greater accuracy among adults <60 years old. FAU - Tonaco, Luis Antonio Batista AU - Tonaco LAB AUID- ORCID: 0000-0001-9660-2900 AD - Universidade Federal de Minas Gerais, Departamento Materno-infantil e Saude Publica, Belo Horizonte, MG, Brazil Universidade Federal de Minas Gerais Departamento Materno-infantil e Saude Publica Belo HorizonteMG Brazil. FAU - Felisbino-Mendes, Mariana Santos AU - Felisbino-Mendes MS AUID- ORCID: 0000-0001-5321-5708 AD - Universidade Federal de Minas Gerais, Departamento Materno-infantil e Saude Publica, Belo Horizonte, MG, Brazil Universidade Federal de Minas Gerais Departamento Materno-infantil e Saude Publica Belo HorizonteMG Brazil. FAU - Moreira, Alexandra Dias AU - Moreira AD AUID- ORCID: 0000-0002-4477-5241 AD - Universidade Federal de Minas Gerais, Departamento Materno-infantil e Saude Publica, Belo Horizonte, MG, Brazil Universidade Federal de Minas Gerais Departamento Materno-infantil e Saude Publica Belo HorizonteMG Brazil. FAU - Romeiro, Amanda Maria de Sousa AU - Romeiro AMS AUID- ORCID: 0000-0002-6769-3978 AD - Universidade Federal de Goias, Faculdade de Medicina, Goiania, GO, Brazil Universidade Federal de Goias Faculdade de Medicina GoianiaGO Brazil. FAU - Silveira, Erika Aparecida AU - Silveira EA AUID- ORCID: 0000-0002-8839-4520 AD - Universidade Federal de Goias, Faculdade de Medicina, Goiania, GO, Brazil Universidade Federal de Goias Faculdade de Medicina GoianiaGO Brazil. FAU - Souza, Maria Jose Silva AU - Souza MJS AUID- ORCID: 0000-0002-1640-7441 AD - Universidade Federal de Minas Gerais, Departamento Materno-infantil e Saude Publica, Belo Horizonte, MG, Brazil Universidade Federal de Minas Gerais Departamento Materno-infantil e Saude Publica Belo HorizonteMG Brazil. FAU - Velasquez-Melendez, Gustavo AU - Velasquez-Melendez G AUID- ORCID: 0000-0001-8349-5042 AD - Universidade Federal de Minas Gerais, Departamento Materno-infantil e Saude Publica, Belo Horizonte, MG, Brazil Universidade Federal de Minas Gerais Departamento Materno-infantil e Saude Publica Belo HorizonteMG Brazil. LA - eng LA - por PT - Journal Article DEP - 20260704 PL - Brazil TA - Epidemiol Serv Saude JT - Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil JID - 101248287 RN - 0 (Glycated Hemoglobin) SB - IM MH - Humans MH - *Prediabetic State/diagnosis/epidemiology MH - Cross-Sectional Studies MH - Female MH - Brazil/epidemiology MH - Male MH - Middle Aged MH - *Diabetes Mellitus/diagnosis/epidemiology MH - Adult MH - Prevalence MH - Body Mass Index MH - ROC Curve MH - Sensitivity and Specificity MH - Early Diagnosis MH - Waist Circumference/physiology MH - Glycated Hemoglobin/metabolism/analysis MH - Young Adult MH - Aged MH - Predictive Value of Tests MH - *Anthropometry MH - Area Under Curve MH - Adolescent PMC - PMC13686399 OTO - NOTNLM OT - Anthropometry. OT - Cross-Sectional Studies OT - Diabetes Mellitus OT - Prediabetic State OT - ROC Curve COIS- Conflict of interest : None to declare. EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 PMCR- 2026/07/04 CRDT- 2026/10/24 10:22 PHST- 2025/09/16 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 10:22 [entrez] PHST- 2026/07/04 00:00 [pmc-release] AID - 10.1590/S2237-96222026v35e20240606.en [doi] PST - epublish SO - Epidemiol Serv Saude. 2026 Jul 4;35:e20240606. doi: 10.1590/S2237-96222026v35e20240606.en. eCollection 2026. PMID- 42922747 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261025 IS - 2237-9622 (Electronic) IS - 1679-4974 (Print) IS - 1679-4974 (Linking) VI - 35 DP - 2026 TI - Self-reported fruit and vegetable intake obtained through a brief telephone interview among users of the Academia da Saude Program: a validation study, Belo Horizonte, Minas Gerais, Brazil, 2016-2017. PG - e20250817 LID - 10.1590/S2237-96222026v35e20250817.en [doi] LID - e20250817 AB - OBJECTIVE: To assess the validity of fruit and vegetable intake data among users of a health promotion service of the Brazilian Unified Health System (Sistema Unico de Saude, SUS). METHODS: Validation study conducted between 2016 and 2017 in the Health Academy Program (Programa Academia da Saude) in Belo Horizonte, Minas Gerais, Brazil. Fruit and vegetable intake was estimated using a brief questionnaire administered in a telephone interview and validated through face-to-face interviews. For statistical analyses of the total sample and the sex-stratified sample, one-sample t-tests, the Concordance Correlation Coefficient (CCC), Bland-Altman plots, and limits of agreement were used. RESULTS: A total of 441 respondents were included, of whom 378 (85.7%) were women, and 255 (57.8%) were adults. After stratification by sex, the differences between methods were equal to zero. Agreement between the methods was substantial for fruit intake (CCC ranging from 0.632 to 0.696), and low to moderate for vegetable intake (CCC ranging from 0.397 to 0.500). When stratified by education level, the differences were not equal to zero, but there was moderate-to-substantial agreement between the methods for fruit intake (CCC ranging from 0.572 to 0.766) and moderate agreement for vegetable intake (CCC ranging from 0.405 to 0.513). The Bland-Altman plots showed that the differences between the methods were centered around zero and remained stable at higher intake levels. CONCLUSION: Data obtained from telephone interviews were valid for estimating fruit and vegetable intake among SUS users. FAU - de Carvalho, Maria Cecilia Ramos AU - de Carvalho MCR AUID- ORCID: 0000-0002-8947-2121 AD - Universidade Federal de Minas Gerais, Grupo de Pesquisa de Intervencoes em Nutricao, Belo Horizonte, MG, Brazil Universidade Federal de Minas Gerais Grupo de Pesquisa de Intervencoes em Nutricao Belo HorizonteMG Brazil. FAU - Lopes, Mariana Souza AU - Lopes MS AUID- ORCID: 0000-0003-3128-7959 AD - Universidade Federal da Paraiba, Departamento de Nutricao, Joao Pessoa, PB, Brazil Universidade Federal da Paraiba Departamento de Nutricao Joao PessoaPB Brazil. FAU - de Freitas, Patricia Pinheiro AU - de Freitas PP AUID- ORCID: 0000-0001-9355-3066 AD - Universidade Federal dos Vales do Jequitinhonha e Mucuri, Departamento de Nutricao, Diamantina, MG, Brazil Universidade Federal dos Vales do Jequitinhonha e Mucuri Departamento de Nutricao DiamantinaMG Brazil. FAU - Lopes, Aline Cristine Souza AU - Lopes ACS AUID- ORCID: 0000-0001-9782-2606 AD - Universidade Federal de Minas Gerais, Departamento de Nutricao, Belo Horizonte, MG, Brazil Universidade Federal de Minas Gerais Departamento de Nutricao Belo HorizonteMG Brazil. LA - eng LA - por PT - Journal Article PT - Validation Study DEP - 20260624 PL - Brazil TA - Epidemiol Serv Saude JT - Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil JID - 101248287 SB - IM MH - Humans MH - Brazil MH - *Fruit MH - *Vegetables MH - Female MH - Male MH - Adult MH - Interviews as Topic MH - *Self Report MH - Middle Aged MH - Surveys and Questionnaires MH - Reproducibility of Results MH - Young Adult MH - Telephone MH - Health Promotion/methods MH - *Diet/statistics & numerical data MH - Adolescent PMC - PMC13686308 OTO - NOTNLM OT - Eating OT - Fruit OT - Nutritional Assessment OT - Validation Study OT - Vegetables COIS- Conflict of interest: None to declare. EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 PMCR- 2026/06/24 CRDT- 2026/10/24 10:19 PHST- 2025/08/01 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 10:19 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.1590/S2237-96222026v35e20250817.en [doi] PST - epublish SO - Epidemiol Serv Saude. 2026 Jun 24;35:e20250817. doi: 10.1590/S2237-96222026v35e20250817.en. eCollection 2026. PMID- 42921903 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261024 IS - 1399-3046 (Electronic) IS - 1397-3142 (Linking) VI - 30 IP - 10 DP - 2026 Oct TI - The Relationship Between Estimated and Measured Glomerular Filtration Rate in Pediatric Hematopoietic Stem Cell Transplant Candidates. LID - e70507 [pii] LID - 10.1111/petr.70507 [doi] AB - BACKGROUND: Accurate assessment of renal function through glomerular filtration rate (GFR) is a vital parameter in determining eligibility for hematopoietic stem cell transplantation (HSCT), as conditioning regimens often include nephrotoxic agents. Technetium-99 m diethylenetriaminepentaacetic acid (Tc-99m DTPA) nuclear scans are commonly used to measure GFR, but creatinine-based formulas may be more convenient and cost-effective. This study compared three contemporary creatinine-based equations, the bedside Schwartz, Full Age Spectrum (FAS), and CKiD U25 creatinine equations with the Tc-99 m DTPA measured GFR (mGFR) in pediatric HSCT candidates. MATERIALS AND METHODS: This retrospective cohort included 100 transplant episodes in pediatric patients undergoing autologous or allogeneic HSCT at King Abdulaziz Medical City, Jeddah. Agreement was evaluated using mean bias, standard deviation of the differences (precision), 95% limits of agreement, root-mean-square error, P10, P30, Lin's concordance correlation coefficient, and Bland-Altman analyses using both absolute and percentage differences. Exploratory subgroup analyses were conducted by sex and transplant type. RESULTS: The cohort included 59 male and 41 female transplant episodes; 57 were autologous and 43 were allogeneic. Mean Tc-99 m DTPA mGFR was 113.0 mL/min/1.73 m(2). Mean eGFR values were 112.4 for Schwartz, 102.2 for FAS, and 98.3 mL/min/1.73 m(2) for U25. Schwartz had the smallest mean absolute bias (-0.6 mL/min/1.73 m(2)) but poor concordance (CCC 0.19), wide limits of agreement (-57.8 to 56.6), P10 of 27%, and P30 of 76%. FAS and U25 showed systematic underestimation, with biases of -11.0 and -14.7 mL/min/1.73 m(2), respectively. Root-mean-square error was 29.0, 30.2, and 31.7 mL/min/1.73 m(2) for Schwartz, FAS, and U25, respectively. Performance remained limited across sex and transplant-type subgroups. CONCLUSION: None of the three creatinine-based equations demonstrated sufficient individual-level agreement with Tc-99 m DTPA mGFR to replace measured GFR in pediatric HSCT candidates. Schwartz showed minimal average bias but substantial imprecision, whereas FAS and U25 tended to underestimate mGFR. Creatinine-based eGFR remains useful for routine monitoring, but radionuclide measurement should be retained when precise renal assessment may affect transplant eligibility or nephrotoxic drug dosing. CI - (c) 2026 Wiley Periodicals LLC. FAU - Monagel, Dania A AU - Monagel DA AUID- ORCID: 0000-0002-0469-6733 AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. AD - King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. AD - Department of Pediatric Oncology, Ministry of the National Guard- Health Affairs, Jeddah, Saudi Arabia. FAU - Altaf, Wid F AU - Altaf WF AUID- ORCID: 0009-0001-9712-5437 AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. AD - King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. FAU - Bokhari, Maya F AU - Bokhari MF AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. AD - King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. FAU - Afif, Afnan Bin AU - Afif AB AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. AD - King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. FAU - Alaslab, Alanoud K AU - Alaslab AK AUID- ORCID: 0009-0008-8307-4756 AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. AD - King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. FAU - Bamehriz, Amal M AU - Bamehriz AM AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. AD - King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. FAU - Alidreesi, Kinan A AU - Alidreesi KA AUID- ORCID: 0009-0009-4991-8190 AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. AD - King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. FAU - Althubaiti, Alaa AU - Althubaiti A AUID- ORCID: 0000-0002-4175-1703 AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Jeddah, Saudi Arabia. AD - King Abdullah International Medical Research Center, Jeddah, Saudi Arabia. LA - eng PT - Journal Article PL - Denmark TA - Pediatr Transplant JT - Pediatric transplantation JID - 9802574 RN - VW78417PU1 (Technetium Tc 99m Pentetate) RN - AYI8EX34EU (Creatinine) RN - 0 (Radiopharmaceuticals) SB - IM MH - Humans MH - *Glomerular Filtration Rate MH - *Hematopoietic Stem Cell Transplantation MH - Female MH - Male MH - Child MH - Retrospective Studies MH - Child, Preschool MH - Adolescent MH - Technetium Tc 99m Pentetate MH - Infant MH - Creatinine/blood MH - Radiopharmaceuticals MH - Kidney Function Tests/methods OTO - NOTNLM OT - Tc-99m diethylenetriaminepentaacetic acid4 OT - glomerular filtration rate2 OT - hematopoietic stem cell transplant1 OT - pediatrics3 OT - schwartz formula5 EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 CRDT- 2026/10/24 09:34 PHST- 2026/09/28 00:00 [revised] PHST- 2026/05/19 00:00 [received] PHST- 2026/10/03 00:00 [accepted] PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 09:34 [entrez] AID - e70507 [pii] AID - 10.1111/petr.70507 [doi] PST - ppublish SO - Pediatr Transplant. 2026 Oct;30(10):e70507. doi: 10.1111/petr.70507. PMID- 42921813 OWN - NLM STAT- Publisher LR - 20261024 IS - 1550-9109 (Electronic) IS - 0161-8105 (Linking) DP - 2026 Oct 24 TI - The Sleep-Wake Classification Performance of Pediatric-Trained Machine Learning Algorithms for Raw Accelerometer Data. LID - zsag282 [pii] LID - 10.1093/sleep/zsag282 [doi] AB - STUDY OBJECTIVES: Actigraphy sleep-wake classification methods increasingly seek to leverage raw acceleration data and machine-learning-based classification, but performance evaluation in pediatrics is limited. We trained machine-learning models using pediatric data and compared their sleep-wake classification performance with existing algorithms for children. METHODS: Sixty-five children (46% female, ages 5.3-17.7 years) completed in-lab overnight polysomnography and wore a GENEActiv device on their non-dominant wrist. The acceleration data were converted into 30-second epochs and aligned with physician-scored sleep-wake data from electroencephalography. Eight machine-learning models were trained using leave-one-subject-out cross-validation. Epoch-by-epoch analyses generated performance metrics (e.g., balanced accuracy [BA]) and discrepancy analyses provided overall sleep duration bias estimates. The combination of highest performance and least bias was used to rank using Euclidean distance scores - where a lower score represents closer to perfect performance and zero bias. For benchmarking, we included GGIR sleep scoring algorithms and an adult trained random forest classifier. RESULTS: Overall, 560.1 hours of polysomnography and actigraphy data were collected (74.4% of epochs were scored as sleep). The pediatric-trained local-global long-short term memory (LSTM) classifier had the most optimal epoch-by-epoch performance (e.g., BA=0.85, sensitivity=0.88, specificity=0.83, ROC-AUC=0.95, and Cohen's kappa=0.67). These metrics exceeded that of an adult-trained random forest classifier and GGIR-based algorithms. Discrepancy analyses revealed that overall sleep duration was underestimated by an average of 25 minutes using the LSTM classifier with no proportional bias. CONCLUSIONS: We trained eight pediatric sleep-wake classifiers that had a strong ability to detect sleep and wake, with the LSTM classifier being most optimal. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Sleep Research Society. FAU - Chen, Pin-Wei AU - Chen PW AUID- ORCID: 0000-0002-4394-1519 AD - Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Cielo, Christopher AU - Cielo C AUID- ORCID: 0000-0001-5761-6373 AD - Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA. AD - Division of Pulmonology and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Walch, Olivia AU - Walch O AD - Arcascope, Inc., Arlington, VA, USA. AD - Department of Neurology, School of Medicine, University of Michigan, Ann Arbor, MI, USA. FAU - McDonald, Morgan AU - McDonald M AD - Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Song, Peter X K AU - Song PXK AD - Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, MI, USA. FAU - Goldstein, Cathy AU - Goldstein C AD - Department of Neurology, School of Medicine, University of Michigan, Ann Arbor, MI, USA. FAU - Moreno, Jennette P AU - Moreno JP AUID- ORCID: 0000-0002-9372-6104 AD - Department of Pediatrics-Nutrition, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA. FAU - Jansen, Erica C AU - Jansen EC AUID- ORCID: 0000-0002-3364-3729 AD - Department of Nutritional Sciences, University of Michigan, Ann Arbor, MI, USA. FAU - Mitchell, Jonathan A AU - Mitchell JA AD - Department of Pediatrics, University of Pennsylvania, Philadelphia, PA, USA. AD - Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA. LA - eng PT - Journal Article DEP - 20261024 PL - United States TA - Sleep JT - Sleep JID - 7809084 SB - IM OTO - NOTNLM OT - Actigraphy OT - Machine Learning OT - Pediatrics OT - Sleep-wake Classification OT - Validation study OT - Wearable Sensors EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:36 CRDT- 2026/10/24 08:34 PHST- 2026/06/12 00:00 [received] PHST- 2026/09/28 00:00 [revised] PHST- 2026/10/16 00:00 [accepted] PHST- 2026/10/25 03:36 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 08:34 [entrez] AID - 8996764 [pii] AID - 10.1093/sleep/zsag282 [doi] PST - aheadofprint SO - Sleep. 2026 Oct 24:zsag282. doi: 10.1093/sleep/zsag282. PMID- 42921283 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261024 LR - 20261026 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 10 DP - 2026 Oct TI - Beyond Observable Behavior: A Narrative Review of Integrated Clinical, Biological, and Functional Assessment in Children With Autism Spectrum Disorder. PG - e118440 LID - 10.7759/cureus.118440 [doi] LID - e118440 AB - Assessment of children with autism spectrum disorder must characterize everyday functioning, co-occurring conditions, and individual support needs alongside diagnostic classification. This narrative review examines the evidence and clinical rationale for integrated clinical, biological, and functional assessment in pediatric autism and presents SMART-NB as a proposed framework for organizing these dimensions. The review combines selected clinical guidelines and research publications with conceptual analysis and a targeted literature update, distinguishing established assessment principles from the author-developed framework. Three findings emerge. First, standardized observational instruments contribute to diagnosis but require interpretation alongside developmental history, caregiver information, differential diagnosis, and clinical judgment. Second, co-occurring sleep disturbances, gastrointestinal symptoms, nutritional problems, sensory impairments, and pain can influence behavior and participation and warrant clinically directed evaluation; their association with autism does not establish causation. Third, symptom severity does not fully describe adaptive functioning, supporting assessment across functional domains and everyday contexts. SMART-NB proposes connecting clinical, medical and biological, and demand-related profiles with seven functional domains, individualized goals, and longitudinal reassessment. The demand dimension examines available capacity, physiological and emotional burden, environmental requirements, and supports. Its proposed contribution is to document how assessment findings inform care priorities. Existing multidimensional approaches already address overlapping aspects of this task; the incremental value of this particular organization remains untested. The reviewed evidence supports multidimensional assessment but does not establish the validity, reliability, or clinical utility of SMART-NB. This review is not systematic, and extension beyond autism remains a hypothesis requiring condition-specific evaluation. Development should proceed from operational specification, independent content assessment, and feasibility studies to the evaluation of measurement properties and comparative clinical outcomes. CI - Copyright (c) 2026, Sanabria et al. FAU - Sanabria, Florencia AU - Sanabria F AD - Neurodevelopment, Instituto HELMAR, Mar del Plata, ARG. LA - eng PT - Journal Article PT - Review DEP - 20261023 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13692760 OTO - NOTNLM OT - #clinical decision-making OT - autism spectrum disorder (asd) OT - clinical assessment tools OT - differential diagnosis OT - functional assessment OT - medical comorbidities OT - neurodevelopmental disorders (nd) OT - pediatric neurodevelopment OT - smart-nb OT - therapeutic goals COIS- Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: The author is the creator and developer of SMART-NB, the clinical framework discussed in this manuscript. This relationship is disclosed for transparency. No external funding was received for this work. . EDAT- 2026/10/25 03:36 MHDA- 2026/10/25 03:37 PMCR- 2026/10/23 CRDT- 2026/10/24 05:32 PHST- 2026/10/22 00:00 [accepted] PHST- 2026/10/25 03:37 [medline] PHST- 2026/10/25 03:36 [pubmed] PHST- 2026/10/24 05:32 [entrez] PHST- 2026/10/23 00:00 [pmc-release] AID - 10.7759/cureus.118440 [doi] PST - epublish SO - Cureus. 2026 Oct 23;18(10):e118440. doi: 10.7759/cureus.118440. eCollection 2026 Oct. PMID- 42920663 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261025 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - An expert-informed framework of school conditions potentially supporting adolescent physical activity habits: a three-stage consultation in China. PG - 1962254 LID - 10.3389/fpubh.2026.1962254 [doi] LID - 1962254 AB - BACKGROUND: Schools can provide conditions that may support repeated physical activity, but expert endorsement of those conditions does not demonstrate habit formation. This study developed an expert-informed content framework for Chinese adolescents aged 12-18 years. METHODS: A three-stage, Delphi-informed consultation comprised qualitative elicitation and item development, one full quantitative rating stage, and targeted review of proposed final decisions. Of 25 experts approached, 23, 18, and 16 were reported to complete Stages 1, 2, and 3, respectively. The reported analyses used 16 complete cases. Seven earlier-stage contributors withdrew consent; their data are excluded and recorded as no longer retained, preventing full-stage reanalysis. Five theory-informed domains guided the interviews; a predominantly deductive qualitative analysis using a codebook specified before the interviews supported indicator refinement rather than independently establishing their structure. Forty-five literature-derived provisional indicators and five interview-derived additions were consolidated into 34 candidates. Importance, feasibility, and clarity were rated on five-point scales. The importance-based retention rule specified before rating combined a mean >/=4.00, coefficient of variation /=80% ratings of 4 or 5. RESULTS: Thirty-three candidates met the retention rule; SPC9 did not. The retained indicators received uniformly high importance endorsement, but concordance in relative rankings was limited (Kendall's W: importance 0.115, feasibility 0.160, clarity 0.163). Individual-level Stage 3 confirmation distributions were not available in the submitted analytic record, and quantitative convergence across stages was not assessed. The exploratory, sample-relative importance-feasibility matrix assigned 10, 5, 10, and 8 indicators to its four quadrants; 11 of 33 indicators changed quadrant in at least one leave-one-expert-out analysis. CONCLUSION: The resulting curricular, extracurricular, peer, cultural, and institutional indicators specify school conditions that experts considered potentially relevant to habit support. The findings do not establish strong inter-expert consensus, a validated measurement instrument, actual habit formation, or causal effects. Complete-case selection, limited stakeholder representation, and incomplete process records restrict interpretation. More complete source documentation, stakeholder co-design, and prospective measurement and implementation studies are needed. CI - Copyright (c) 2026 Hu, Su, Han, Li, Wang, Liu, Xiong and Li. FAU - Hu, Shaojuan AU - Hu S AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. FAU - Su, Yi AU - Su Y AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. FAU - Han, Dong AU - Han D AD - Shenzhen No. 3 Senior High School, Shenzhen, China. FAU - Li, Liting AU - Li L AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. FAU - Wang, Ran AU - Wang R AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. FAU - Liu, Yihang AU - Liu Y AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. FAU - Xiong, Jie AU - Xiong J AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. FAU - Li, Xinyuan AU - Li X AD - College of Physical Education and Sports Science, Hengyang Normal University, Hengyang, China. LA - eng PT - Journal Article DEP - 20261009 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - *Schools MH - Child MH - China MH - *Exercise/psychology MH - Delphi Technique MH - *Habits MH - Female MH - Male MH - *Adolescent Behavior/psychology PMC - PMC13690933 OTO - NOTNLM OT - China OT - adolescent OT - expert consultation OT - habit support OT - modified Delphi approach OT - physical activity OT - school health promotion COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/24 05:35 MHDA- 2026/10/25 03:36 PMCR- 2026/10/09 CRDT- 2026/10/24 04:55 PHST- 2026/08/08 00:00 [received] PHST- 2026/09/13 00:00 [revised] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/10/25 03:36 [medline] PHST- 2026/10/24 05:35 [pubmed] PHST- 2026/10/24 04:55 [entrez] PHST- 2026/10/09 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1962254 [doi] PST - epublish SO - Front Public Health. 2026 Oct 9;14:1962254. doi: 10.3389/fpubh.2026.1962254. eCollection 2026. PMID- 42920505 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261024 LR - 20261025 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 13 DP - 2026 TI - Development and temporal validation of a calibrated machine learning model for in-hospital blood culture positivity using routine clinical data. PG - 1956921 LID - 10.3389/fmed.2026.1956921 [doi] LID - 1956921 AB - BACKGROUND: Among hospitalized patients who have already undergone blood culture collection, routinely available clinical information may support early risk stratification while microbiological results are pending. We developed and temporally validated a calibrated machine learning model for in-hospital blood culture positivity. METHODS: This single-center retrospective study included 44,389 blood culture-related hospitalization records from January 2022 to September 2024. Records from 2022 to 2023 were used for model development and records from 2024 for temporal validation. The primary outcome was at least one laboratory-recorded positive blood culture between index collection and hospital discharge. A Platt-calibrated XGBoost model using demographic characteristics, routine laboratory variables, and missingness indicators was compared with procalcitonin-only and regression-based models. Performance was assessed using discrimination, calibration, threshold-specific metrics, decision curve analysis, and SHAP. RESULTS: The cohort included 3,555 outcome-positive records (8.01%). In temporal validation, the final XGBoost model achieved a ROC-AUC of 0.798 (95% CI, 0.784-0.813), a PR-AUC of 0.266, a Brier score of 0.0619, and a calibration slope of 1.061. At the 5% threshold, sensitivity was 0.877, specificity 0.570, and negative predictive value 0.983. XGBoost showed a modest improvement over logistic regression with missingness indicators, while an exploratory post hoc Age + PCT + BMI logistic comparator achieved a ROC-AUC of 0.757. Performance was stable in the new-patient validation subset but decreased within adult and pediatric subgroups (ROC-AUC 0.679 and 0.663, respectively). Age, procalcitonin, and body mass index were the dominant contributors. CONCLUSION: The calibrated model provided moderate discrimination and favorable calibration for hospitalization-level blood culture positivity risk stratification in the pooled temporal validation cohort. Performance varied across age groups, and much of the predictive information was concentrated in age, PCT, and BMI. The model does not predict the index culture result alone or diagnose clinically adjudicated bloodstream infection. Multicenter external and prospective validation using fixed prediction horizons and adjudicated outcomes is required before clinical implementation. CI - (c) 2026 Huang, Tan, Jiang, Yang, Wang and Huang. FAU - Huang, Tao AU - Huang T AD - Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, China. AD - School of Pharmacy, Southwest Medical University, Luzhou, China. FAU - Tan, Zhenzhen AU - Tan Z AD - School of Pharmacy, Southwest Medical University, Luzhou, China. AD - Department of Pharmacy, The Hejiang People's Hospital, Luzhou, China. FAU - Jiang, Longyang AU - Jiang L AD - Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, China. AD - School of Pharmacy, Southwest Medical University, Luzhou, China. FAU - Yang, Xuping AU - Yang X AD - Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, China. AD - School of Pharmacy, Southwest Medical University, Luzhou, China. FAU - Wang, Shurong AU - Wang S AD - Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, China. AD - School of Pharmacy, Southwest Medical University, Luzhou, China. FAU - Huang, Yilan AU - Huang Y AD - Department of Pharmacy, The Affiliated Hospital, Southwest Medical University, Luzhou, China. AD - School of Pharmacy, Southwest Medical University, Luzhou, China. LA - eng PT - Journal Article DEP - 20261009 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC13690682 OTO - NOTNLM OT - XGBoost OT - blood culture positivity OT - clinical risk stratification OT - electronic health records OT - machine learning OT - probability calibration OT - temporal validation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/24 05:35 MHDA- 2026/10/24 05:36 PMCR- 2026/10/09 CRDT- 2026/10/24 04:44 PHST- 2026/08/03 00:00 [received] PHST- 2026/09/22 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/24 05:36 [medline] PHST- 2026/10/24 05:35 [pubmed] PHST- 2026/10/24 04:44 [entrez] PHST- 2026/10/09 00:00 [pmc-release] AID - 10.3389/fmed.2026.1956921 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Oct 9;13:1956921. doi: 10.3389/fmed.2026.1956921. eCollection 2026. PMID- 42920015 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261027 IS - 1863-2491 (Electronic) IS - 1863-2483 (Linking) VI - 20 IP - 1 DP - 2026 Oct 24 TI - Body weight-associated procedural bottlenecks in robot-assisted surgery for congenital biliary dilatation: a step-specific operative time analysis. LID - 1132 [pii] LID - 10.1007/s11701-026-04085-y [doi] AB - Adults and heavier patients undergoing robot-assisted surgery for congenital biliary dilatation may require longer operative times. This study used step-specific video analysis to identify where additional time accumulated and which components remained relatively stable across patient size. Fifty-five patients (32 children and 23 adults) were retrospectively analyzed. Operative videos were divided into seven predefined steps and unclassified time. Step-specific durations were compared between groups. Restricted cubic spline and segmented regression analyses explored relationships between body weight and step-specific operative time. Total operative time was longer in adults than in children (509.0 vs. 386.0 min; P < 0.001). Adults required longer times for access and preparation, the Kocher maneuver, pancreatic-side bile duct dissection, Roux-en-Y limb creation and mesenteric fixation, final procedural steps, and unclassified workflow time. Hepatic duct dissection and ductoplasty and hepaticojejunostomy times were similar between groups. Pancreatic-side dissection time was longer in patients with postoperative pancreatic fistulas than in those without it (83.0 vs. 73.0 min; P = 0.039). Segmented regression yielded an exploratory breakpoint estimate of 17.8 kg (95% confidence interval, 9.6-25.9 kg). Using 18 kg as a data-derived exploratory cutoff, patients weighing >/= 18 kg had longer access, dissection, intestinal preparation, and workflow times, without significant differences in biliary reconstruction times. Longer operative times in adults and heavier patients were concentrated in access, pancreatic-side bile duct dissection, intestinal preparation, and workflow, with no significant difference in biliary reconstruction times. The fistula association and the breakpoint are hypothesis-generating findings that require external validation. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature. FAU - Hayashi, Kaito AU - Hayashi K AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Shirota, Chiyoe AU - Shirota C AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Tainaka, Takahisa AU - Tainaka T AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. tainaka.takahisa.g2@f.mail.nagoya-u.ac.jp. FAU - Makita, Satoshi AU - Makita S AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Okamoto, Masamune AU - Okamoto M AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Yasui, Akihiro AU - Yasui A AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Takimoto, Aitaro AU - Takimoto A AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Takada, Shunya AU - Takada S AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Kato, Daiki AU - Kato D AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Ishii, Hiroki AU - Ishii H AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Asai, Hajime AU - Asai H AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Ota, Kazuki AU - Ota K AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Utsunomiya, Ami AU - Utsunomiya A AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. FAU - Uchida, Hiroo AU - Uchida H AD - Department of Pediatric Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. LA - eng GR - JP26vk0124014/Japan Agency for Medical Research and Development/ GR - JP26K03317/Japan Society for the Promotion of Science/ PT - Journal Article DEP - 20261024 PL - England TA - J Robot Surg JT - Journal of robotic surgery JID - 101300401 SB - IM MH - Humans MH - *Operative Time MH - *Robotic Surgical Procedures/methods MH - Retrospective Studies MH - Female MH - Adult MH - Male MH - *Body Weight MH - Child MH - Child, Preschool MH - *Biliary Tract Surgical Procedures/methods MH - Adolescent MH - Infant MH - *Bile Ducts/surgery/abnormalities OTO - NOTNLM OT - Body weight OT - Congenital biliary dilatation OT - Hepaticojejunostomy OT - Operative time OT - Pancreatic fistula OT - Robotic surgery COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics Approval: This study was approved by the Institutional Review Board of Nagoya University Hospital (approval no. 2025-0583). Consent to Participate: The requirement for written informed consent was waived because of the retrospective study design. An opt-out approach was used. Consent to Publish: Not applicable. EDAT- 2026/10/24 05:35 MHDA- 2026/10/24 05:36 CRDT- 2026/10/23 23:20 PHST- 2026/09/08 00:00 [received] PHST- 2026/10/12 00:00 [accepted] PHST- 2026/10/24 05:36 [medline] PHST- 2026/10/24 05:35 [pubmed] PHST- 2026/10/23 23:20 [entrez] AID - 10.1007/s11701-026-04085-y [pii] AID - 10.1007/s11701-026-04085-y [doi] PST - epublish SO - J Robot Surg. 2026 Oct 24;20(1):1132. doi: 10.1007/s11701-026-04085-y. PMID- 42919594 OWN - NLM STAT- In-Process LR - 20261029 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 10 DP - 2026 Oct 23 TI - Lifestyle intervention to improve outcomes in dichorionic twin pregnancies: study protocol for a multicentre randomised controlled trial with an integrated pilot study - the LIFETWIN trial. PG - e122541 LID - 10.1136/bmjopen-2026-122541 [doi] LID - e122541 AB - INTRODUCTION: Preterm birth and small-for-gestational-age (SGA) infants remain major contributors to neonatal morbidity, mortality and healthcare costs. Twin pregnancies account for a disproportionate share of these adverse outcomes, representing 18%-24% of all preterm births in Europe. Despite this high-risk profile, effective preventive strategies for twin pregnancies remain limited and mainly target cervical length. Emerging evidence suggests that maternal lifestyle factors, including diet, physical activity and stress management, may prolong gestational age and improve fetal growth. METHODS AND ANALYSIS: The LIFEstyle intervention to improve TWIN pregnancy (LIFETWIN) - study is a multicentre, open-label, randomised controlled trial. A total of 274 women with dichorionic twin pregnancies will be recruited across 15 sites in Belgium. The full trial will be preceded by an integrated pilot study conducted at four sites to assess feasibility using the RE-AIM framework. Participants will be randomised to standard care or a lifestyle intervention in addition to standard care. The intervention consists of eight midwife-led sessions between gestational weeks 16 and 36, focusing on a Mediterranean-type diet, physical activity, mindfulness and prenatal multivitamin supplementation. Data are collected at baseline, in late pregnancy, at delivery and at 6 weeks postpartum, using clinical records, physical examinations and validated questionnaires. The primary outcome is gestational age at delivery. Secondary outcomes include neonatal birth weight, SGA status, neonatal morbidity and mortality, neonatal intensive care unit admission and length of stay, maternal gestational weight gain, postpartum weight and quality of life. The primary outcome, gestational age at delivery, will be analysed using a linear mixed-effects model, accounting for study-site effects and potential clustering by intervention midwife within the intervention arm. Secondary outcomes will be analysed using models appropriate to the outcome type, including linear mixed models, generalised mixed models and frailty models. ETHICS AND DISSEMINATION: The trial has been approved by the central ethics committee of Leuven (identification number S68251) and by the local ethics committees of each participating site. The trial will be conducted in accordance with the Declaration of Helsinki. All results, whether positive, negative or inconclusive, will be disseminated at national or international scientific meetings and published in peer-reviewed scientific journals. TRIAL REGISTRATION NUMBER: NCT07270640. FAU - Lodewyckx, Katleen AU - Lodewyckx K AUID- ORCID: 0009-0000-6181-1649 AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. FAU - Shafran, Yael Winter AU - Shafran YW AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. FAU - Coucke, Birgit AU - Coucke B AUID- ORCID: 0000-0003-0285-6665 AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Academic Centre for Nursing and Midwifery (AccentVV), Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium. FAU - Put, Martien AU - Put M AUID- ORCID: 0009-0000-5891-636X AD - Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium. FAU - Lewi, Liesbeth AU - Lewi L AD - Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium. FAU - Bogaerts, Annick AU - Bogaerts A AUID- ORCID: 0000-0003-2718-4682 AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - L-C&Y, KU Leuven Child & Youth Institute, KU Leuven, Leuven, Belgium. AD - University of Plymouth, Faculty of Health, Plymouth, UK. FAU - Smits, Tim AU - Smits T AD - Institute for Media Studies, Katholieke Universiteit Leuven Faculteit Sociale Wetenschappen, Leuven, Belgium. FAU - Noel, Laure AU - Noel L AD - Obstetrics and Gynecology Department, Centre Hospitalier Regional de la Citadelle, Liege, Belgium. FAU - Mesens, Tinne AU - Mesens T AD - Department of Obstetrics and Gynecology, Hospital East-Limburg, Genk, Belgium. FAU - Jani, Jacques AU - Jani J AUID- ORCID: 0000-0003-2252-342X AD - Department of Obstetrics and Gynecology, Brugmann University Hospital, Brussels, Belgium. FAU - Devlieger, Roland AU - Devlieger R AD - REALIFE Research Group, Research Unit Woman and Child, Department of Development and Regeneration, KU Leuven, Leuven, Belgium roland.devlieger@uzleuven.be. AD - Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium. LA - eng PT - Journal Article DEP - 20261023 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM PMC - PMC13711562 OTO - NOTNLM OT - Exercise OT - Life Style OT - Mindfulness OT - NUTRITION & DIETETICS OT - Pregnancy OT - Premature Birth OT - Twin COIS- Competing interests: None declared. EDAT- 2026/10/23 23:32 MHDA- 2026/10/23 23:32 PMCR- 2026/10/23 CRDT- 2026/10/23 21:03 PHST- 2026/10/23 23:32 [medline] PHST- 2026/10/23 23:32 [pubmed] PHST- 2026/10/23 21:03 [entrez] PHST- 2026/10/23 00:00 [pmc-release] AID - bmjopen-2026-122541 [pii] AID - 10.1136/bmjopen-2026-122541 [doi] PST - epublish SO - BMJ Open. 2026 Oct 23;16(10):e122541. doi: 10.1136/bmjopen-2026-122541. PMID- 42919389 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261025 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 23 IP - 1 DP - 2026 Jul 25 TI - Identifying eating behaviour phenotype cut-off scores for childhood obesity: an individual participant data meta-analysis using the Child Eating Behaviour Questionnaire (CEBQ). LID - 10.1186/s12966-026-01951-8 [doi] LID - 98 AB - BACKGROUND: Weight management interventions targeting appetitive traits show promise in treating childhood obesity, yet a tool to identify appetitive phenotypes for personalised treatment is missing. The Child Eating Behaviour Questionnaire (CEBQ) is a widely used measure of eight parent-reported appetitive traits associated with childhood obesity. We aimed to explore the utility of the CEBQ for phenotyping childhood obesity and derive cut-off scores to support clinical decision-making. METHODS: This individual participant data meta-analysis combined cross-sectional data from 17 international studies (N = 15,273) on CEBQ scores and Body Mass Index Standard Deviation Scores from children (2-18 years). The potential of CEBQ subscales (Food Responsiveness, Enjoyment of Food, Emotional Over-eating, Desire to Drink, Satiety Responsiveness, Slowness in Eating, Emotional Under-eating, Food Fussiness) to discriminate weight status was explored in random-effect meta-analyses of Area Under the Curve (AUC) metrics. We explored heterogeneity across studies and age- and sex- specific subgroups. Cut-off scores were derived within subgroups using (a) the Youden's Index and (b) the point maximising specificity after a minimum sensitivity of 60%. We meta-analysed study-specific performance with the selected cut-offs to describe heterogeneity across studies. RESULTS: AUCs for CEBQ subscales ranged from 0.60 to 0.71. The magnitude and shape of associations between CEBQ scores and obesity varied by age and sex. Cut-off performance was generally better in middle- than early childhood. The best performing cut-off score of 2.6 was observed for females aged 7-12 years for Food Responsiveness (Sensitivity: 0.81 [95%CI 0.77, 0.85]; Specificity: 0.85 [95%CI 0.82, 0.88]). High heterogeneity in cut-off performance across studies and wide prediction intervals suggest the need to further investigate external validity. CONCLUSIONS: We provide the first empirically derived CEBQ subscale cut-offs to phenotype children with obesity based on weight-related eating behaviours. Cut-offs could support personalised treatment in clinical and research contexts. FUNDING: MC_UU_00006/6 and MC_UU_00006/5. CI - (c) 2026. The Author(s). FAU - Kudlek, Laura AU - Kudlek L AUID- ORCID: 0000-0003-0947-3640 AD - Institute of Metabolic Science Epidemiology, University of Cambridge, Cambridge, UK. laura.kudlek@ims.cam.ac.uk. AD - Centre for Preventive Medicine and Digital Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany. laura.kudlek@ims.cam.ac.uk. FAU - Smith, Andrea D AU - Smith AD AD - Institute of Metabolic Science Epidemiology, University of Cambridge, Cambridge, UK. FAU - Ruggiero, Cara F AU - Ruggiero CF AD - Institute of Metabolic Science Epidemiology, University of Cambridge, Cambridge, UK. FAU - Pennells, Lisa AU - Pennells L AD - Department of Health and Primary Care, University of Cambridge, Cambridge, UK. FAU - Kininmonth, Alice R AU - Kininmonth AR AD - School of Food Science and Nutrition, University of Leeds, Leeds, UK. AD - Leeds Institute for Data Analytics, University of Leeds, Leeds, UK. FAU - Steinsbekk, Silje AU - Steinsbekk S AD - Department of Psychology, Norwegian University of Science and Technology, Hogskoleringen, Norway. FAU - Jansen, Pauline W AU - Jansen PW AD - Department of Psychology, Education and Child Studies, Erasmus University Rotterdam, Rotterdam, Netherlands. FAU - Ahern, Amy L AU - Ahern AL AD - Institute of Metabolic Science Epidemiology, University of Cambridge, Cambridge, UK. FAU - McCarthy, Elaine K AU - McCarthy EK AD - School of Food and Nutritional Sciences, University College Cork, Cork, Ireland. FAU - Gross, Amy AU - Gross A AD - Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA. FAU - Viana, Victor AU - Viana V AD - Faculty of Food Sciences and Nutrition, University of Porto, Porto, Portugal. FAU - van Deutekom, Arend W AU - van Deutekom AW AD - Department of Paediatrics, Division of Paediatric Cardiology Erasmus MC-Sophia Children's Hospital Rotterdam, Rotterdam,, Netherlands. FAU - Spence, John C AU - Spence JC AD - Faculty of Kinesiology, Sport, & Recreation, University of Alberta, Edmonton, AB, Canada. FAU - Fisher, Jennifer Orlet AU - Fisher JO AD - Department of Social and Behavioral Sciences, College of Public Health, Temple University, Philadelphia, PA, USA. FAU - Hayes, Jacqueline AU - Hayes J AD - Alpert Medical School of Brown University and The Miriam Hospital, Providence, RI, USA. FAU - Haycraft, Emma AU - Haycraft E AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. FAU - Hardman, Charlotte A AU - Hardman CA AD - Department of Psychology, University of Liverpool, Liverpool, UK. FAU - Silveira, Patricia P AU - Silveira PP AD - Department of Psychiatry, McGill University, Montreal, Quebec, Canada. FAU - Emond, Jennifer A AU - Emond JA AD - Department of Biomedical Data Science, Geisel School of Medicine at Dartmouth College, Lebanon, NH, USA. FAU - Eloranta, Aino-Maija AU - Eloranta AM AD - Institute of Public Health and Clinical Nutrition, School of Medicine, University of Eastern Finland, Kuopio, Finland. FAU - Dos Passos Gomes, Darlise R AU - Dos Passos Gomes DR AD - Department of Nutrition, Federal University of Pelotas, Pelotas, RS, Brazil. FAU - Lumeng, Julie C AU - Lumeng JC AD - Department of Pediatrics, University of Michigan, Ann Arbor, MI, USA. FAU - Cross, Matthew B AU - Cross MB AD - USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Bates, Houston, TX, 1100, USA. FAU - Carnell, Susan AU - Carnell S AD - Department of Psychiatry and Behavioral Sciences, Division of Child and Adolescent Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA. FAU - Fildes, Alison AU - Fildes A AD - School of Psychology, University of Leeds, Leeds, UK. FAU - Llewellyn, Clare AU - Llewellyn C AD - Department of Behavioural Science and Health, University College London, London, UK. LA - eng GR - MC_UU_00006/6/MRC_/Medical Research Council/United Kingdom GR - MC_UU_00006/5/MRC_/Medical Research Council/United Kingdom GR - NIHR203312/National Institute for Health and Care Research/ GR - NIHR203312/National Institute for Health and Care Research/ GR - RG/F/23/110103/BHF_/British Heart Foundation/United Kingdom GR - PR:1948633/Economic and Social Research Council/ PT - Journal Article PT - Meta-Analysis DEP - 20260725 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - Child MH - *Feeding Behavior/psychology MH - Phenotype MH - Surveys and Questionnaires MH - Female MH - Child, Preschool MH - Body Mass Index MH - *Pediatric Obesity/psychology/diagnosis MH - Male MH - Cross-Sectional Studies MH - Adolescent MH - *Child Behavior PMC - PMC13693115 OTO - NOTNLM OT - Behavioural obesity phenotypes OT - Child eating behaviour questionnaire (CEBQ) OT - Childhood obesity OT - Cut-off scores COIS- Declarations. Ethics approval and consent to participate: Ethical approval and consent to participate were obtained by original investigators for each included study. No additional ethical approval was obtained for this secondary analysis of original study data. Consent for publication: Not applicable. Competing interests: ALA is a member of the scientific advisory board for Weight Watchers and has undertaken consultancy for Menwell Health and Juniper (all payments to her institution). CAH reports research funding for work unrelated to the submitted manuscript from the American Beverage Association; membership of Global Nutrition Advisory Council for Mars; primary supervisor of PhD studentship funded by Coca-Cola; membership of UK Government's Food Standards Agency's Advisory Committee on Social Sciences; honoraria from International Sweeteners Association and International Food Information Council for invited talks. CL held funding from the UKRI Medical Research Council Grant to support an intervention based on child eating behaviour, involving eating behaviour phenotyping. All other authors have no competing interests to declare. EDAT- 2026/10/23 23:32 MHDA- 2026/10/24 05:35 PMCR- 2026/07/25 CRDT- 2026/10/23 20:52 PHST- 2026/01/09 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/10/24 05:35 [medline] PHST- 2026/10/23 23:32 [pubmed] PHST- 2026/10/23 20:52 [entrez] PHST- 2026/07/25 00:00 [pmc-release] AID - 10.1186/s12966-026-01951-8 [pii] AID - 1951 [pii] AID - 10.1186/s12966-026-01951-8 [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2026 Jul 25;23(1):98. doi: 10.1186/s12966-026-01951-8. PMID- 42913715 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261025 IS - 2190-6009 (Electronic) IS - 2190-5991 (Print) IS - 2190-5991 (Linking) VI - 17 IP - 5 DP - 2026 Oct TI - Machine Learning Integrating Quantitative MRI and Clinical Features Predicts Loss of Ambulation in Duchenne Muscular Dystrophy. LID - e70413 [pii] LID - 10.1002/jcsm.70413 [doi] AB - BACKGROUND: Loss of ambulation (LOA) is a key milestone in Duchenne muscular dystrophy (DMD) with highly variable timing, complicating clinical counselling and trial design. Quantitative MRI non-invasively assesses muscle fat infiltration, yet few models have integrated MRI with clinical variables for individualized LOA prediction. We aimed to develop and validate a machine-learning model integrating quantitative MRI and clinical features to predict time to LOA and to derive interpretable, individualized risk estimates and candidate thresholds. METHODS: This prospective study enrolled 188 boys with DMD (median age 9.10 years). Quantitative MRI parameters (T1, T2, fat fraction [FF]) of 19 hip/thigh muscles and clinical variables were measured. Patients were randomly split into training (80%) and test (20%) sets. Feature selection used LASSO, Boruta and recursive feature elimination based on random survival forest (RSF). Three survival models were compared: RSF and a ridge-penalised Cox model (both integrating clinical and MRI-derived features) and a multivariable Cox model restricted to clinical variables. Performance was assessed by concordance index (C-index), time-dependent area under the curve (AUC), integrated Brier score (IBS) and decision curve analysis at 12, 24, 36 and 48 months. RESULTS: Over median 43.5 months follow-up, 66 patients (35.1%) experienced LOA. Six predictors were retained: NSAA score, MRC%, age and three FF parameters (rectus femoris, vastus lateralis, obturator internus). In the test set (n = 40, 15 events), RSF achieved a C-index of 0.870 (95% CI, 0.764-0.957), outperforming the clinical Cox (0.804) and ridge Cox (0.853) model. Time-dependent AUCs of the RSF model were 0.984, 0.971, 0.913 and 0.850 at 12, 24, 36 and 48 months. RSF showed the best calibration, with the lowest IBS (0.076, 95% CI: 0.052-0.111), followed closely by the ridge Cox model (0.078) and the clinical Cox model (0.109). RSF stratified patients into low-risk, intermediate-risk and high-risk groups; no LOA events occurred in the low-risk group, with annual event rates were 7.2% and 34.6% in the intermediate- and high-risk groups (log-rank p = 0.0025). SHAP analysis identified exploratory thresholds (NSAA < 14.55, MRC% < 68.36%, rectus femoris FF > 32.30%, vastus lateralis FF > 58.00%, obturator internus FF > 7.43%). An interactive web application enables individualized risk prediction (https://westcndmd-timer-loa-risk-prediction-tool-8cygtrrbykvd9snmfcnhrp.streamlit.app/). CONCLUSIONS: A machine-learning-based RSF model integrating quantitative MRI FF metrics and clinical variables exhibited favourable predictive performance for time to LOA in DMD across short- and long-term horizons. It provided interpretable, individualized risk estimates and was deployed as an online tool to support clinical decision-making and trial enrichment. CI - (c) 2026 The Author(s). Journal of Cachexia, Sarcopenia and Muscle published by Wiley Periodicals LLC. FAU - Liu, Chuan AU - Liu C AUID- ORCID: 0000-0002-8126-7684 AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Song, Yu AU - Song Y AUID- ORCID: 0000-0002-1198-0732 AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Wan, Jiayu AU - Wan J AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Xu, Ting AU - Xu T AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Zhang, Xinyuan AU - Zhang X AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Yan, Yiqiao AU - Yan Y AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Fu, Hang AU - Fu H AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Cai, Xiaotang AU - Cai X AUID- ORCID: 0000-0001-8940-8253 AD - Department of Rehabilitation and Department of Pediatric Neurology, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Guo, Yingkun AU - Guo Y AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Wang, Yun AU - Wang Y AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Xu, Huayan AU - Xu H AUID- ORCID: 0000-0003-0801-0695 AD - Department of Radiology, Medical Imaging Center, China Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China. LA - eng GR - HF-CSC2019B01/Clinical Research Funding of Chinese Society of Cardiovascular Disease (CSC)/ GR - 2022-GH03-00011-HZ/Project of Chengdu Science and Technology/ GR - 82572196/National Natural Science Foundation of China/ GR - 82471970/National Natural Science Foundation of China/ GR - 824B2052/National Natural Science Foundation of China/ GR - 82402250/National Natural Science Foundation of China/ GR - 825B2052/National Natural Science Foundation of China/ GR - 2026NSFSCZY0011/Key Project of Natural Science Foundation of Sichuan Province/ GR - 2026NSFSC0584/Natural Science Foundation of Sichuan Province/ GR - 2026-YF08-00166-GX/Chengdu Science and Technology Program/ GR - 2026-XT00-00013-GX/Chengdu Science and Technology Program/ PT - Journal Article PL - Germany TA - J Cachexia Sarcopenia Muscle JT - Journal of cachexia, sarcopenia and muscle JID - 101552883 SB - IM MH - Humans MH - *Muscular Dystrophy, Duchenne/diagnostic imaging/physiopathology/diagnosis MH - *Magnetic Resonance Imaging/methods MH - *Machine Learning MH - Male MH - Child MH - Prospective Studies MH - *Walking MH - Random Forest MH - Predictive Learning Models MH - Prognosis PMC - PMC13690469 OTO - NOTNLM OT - Duchenne muscular dystrophy OT - fat fraction OT - loss of ambulation OT - machine learning OT - quantitative MRI OT - random survival forest COIS- The authors declare no conflicts of interest. EDAT- 2026/10/23 23:31 MHDA- 2026/10/23 23:32 PMCR- 2026/10/22 CRDT- 2026/10/23 17:59 PHST- 2026/09/07 00:00 [revised] PHST- 2026/06/25 00:00 [received] PHST- 2026/10/13 00:00 [accepted] PHST- 2026/10/23 23:32 [medline] PHST- 2026/10/23 23:31 [pubmed] PHST- 2026/10/23 17:59 [entrez] PHST- 2026/10/22 00:00 [pmc-release] AID - e70413 [pii] AID - JCSM70413 [pii] AID - 10.1002/jcsm.70413 [doi] PST - ppublish SO - J Cachexia Sarcopenia Muscle. 2026 Oct;17(5):e70413. doi: 10.1002/jcsm.70413. PMID- 42912754 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261025 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 10 DP - 2026 TI - Determine and compare limb specific predictors based on the foot pressure index of right and left foot among young adults in Saudi Arabia using machine learning models. PG - e0360520 LID - 10.1371/journal.pone.0360520 [doi] LID - e0360520 AB - Foot posture is a key determinant of limb-biomechanics, gait balance as well as functional mobility. Usage of foot pressure index (FPI) is widespread to but the determinants of FPI without accounting to the left right foot differences. Therefore, identifying limb-specific determinants would enhance screening accuracy and help in more targeted interventions. The objective of the study was to determine and compare limb specific predictors based on the foot pressure index of right and left foot among young adults using machine learning models. A total of 581 (290 females and 291 males) 18-25-year-old young adults were assessed on anthropometric measures, joint hyper mobility and functional mobility. Using SAS-Viya, separate entropy-based decision trees, along with logistic regression models were developed and model performance was evaluated using validation-test accuracy and area under the curve (AUC). Decision tree models outperformed logistic regression for both FPI-Left (FPI-L) and FPI-Right (FPIR). FPIR was primarily predicted by joint hyper mobility, followed by stair ascent time, stability as well as BMI with stronger influence of both structural and load related factors. FPIL was predicted by closed-eye balance along BMI, open eye balance, stair ascent, Beighton score, underscoring the role of sensory motor control. The findings of the study reflect that young adults foot posture is complex, limb specific interactions among anthropometric, functional and sensory factors. CI - Copyright: (c) 2026 Samuel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Samuel, Paul Silvian AU - Samuel PS AUID- ORCID: 0000-0002-4920-6347 AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. FAU - Thomas, Resmi Ann AU - Thomas RA AD - College of Business, Centennial College, Toronto, Canada. FAU - Kakaraparthi, Venkata Nagaraj AU - Kakaraparthi VN AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. FAU - Reddy, Ravi Shankar AU - Reddy RS AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. FAU - Alshahrani, Mastour Saeed AU - Alshahrani MS AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. FAU - Alnakhli, Hani H AU - Alnakhli HH AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. FAU - Alkhamis, Batool Abdulelah AU - Alkhamis BA AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. FAU - Gular, Kumar AU - Gular K AD - Department of Medical Rehabilitation Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. LA - eng PT - Comparative Study PT - Journal Article DEP - 20261023 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - *Machine Learning MH - *Foot/physiology MH - Pressure MH - Young Adult MH - Saudi Arabia MH - Male MH - Adolescent MH - Adult MH - Gait/physiology MH - Biomechanical Phenomena MH - Predictive Learning Models PMC - PMC13693902 COIS- The authors have declared that no competing interests exist. EDAT- 2026/10/23 18:31 MHDA- 2026/10/23 18:32 PMCR- 2026/10/23 CRDT- 2026/10/23 13:45 PHST- 2026/04/17 00:00 [received] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/23 18:32 [medline] PHST- 2026/10/23 18:31 [pubmed] PHST- 2026/10/23 13:45 [entrez] PHST- 2026/10/23 00:00 [pmc-release] AID - PONE-D-26-17999 [pii] AID - 10.1371/journal.pone.0360520 [doi] PST - epublish SO - PLoS One. 2026 Oct 23;21(10):e0360520. doi: 10.1371/journal.pone.0360520. eCollection 2026. PMID- 42912465 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261028 IS - 1949-0984 (Electronic) IS - 1949-0976 (Print) IS - 1949-0976 (Linking) VI - 18 IP - 1 DP - 2026 Dec 31 TI - AhR ligands in necrotizing enterocolitis: a provisional evidence map of ligand-specific biology and translational considerations. PG - 2743958 LID - 10.1080/19490976.2026.2743958 [doi] LID - 2743958 AB - Necrotizing enterocolitis (NEC) remains a major cause of gastrointestinal morbidity and mortality in preterm infants, with no targeted mechanism-based therapy. Aryl hydrocarbon receptor (AhR) signaling is an emerging host-microbe interface because it integrates dietary, microbial, milk-derived, and host-derived ligands that regulate intestinal inflammation, epithelial homeostasis, and barrier integrity. Direct NEC-specific evidence for individual AhR ligands, however, remains sparse and uneven. This focused review maps direct NEC intervention evidence, independent replication, human NEC association or ex vivo evidence, AhR dependency, compartment specificity, mechanistic resolution, and translational considerations. Indole-3-carbinol (I3C), the synthetic agonist A18, and 3-indoleacrylic acid (IA) have direct intervention evidence in experimental NEC models. Two independent NEC studies support I3C, although the implicated cellular compartment differs between models. A18 provides direct protection in an experimental NEC model, activates AhR, and exhibits anti-inflammatory effects in human intestinal explants. However, it has not been independently replicated. IA is currently the most comprehensively characterized microbiota-derived ligand in NEC models. However, its mechanistic evidence predominantly comes from one recent study and awaits independent replication. Indole-3-lactic acid, indole-3-acetic acid, and indole-3-sulfate remain physiologically relevant candidates, supported by immature intestinal, human milk, or neonatal metabolic studies. Overall, current evidence supports a ligand-specific view of AhR biology in NEC while highlighting major gaps in replication, human validation, and translational studies. FAU - Ferraris, Laurent AU - Ferraris L AUID- ORCID: 0000-0002-9541-4825 AD - Universite Paris Cite, Inserm, FPRM, Faculte de Pharmacie de Paris, Paris, France. AD - FHU Prem'IMPACT Perinatal inflammation and prematurity, Paris, France. FAU - Ferecatu, Ioana AU - Ferecatu I AUID- ORCID: 0000-0001-6842-9506 AD - Universite Paris Cite, Inserm, FPRM, Faculte de Pharmacie de Paris, Paris, France. AD - FHU Prem'IMPACT Perinatal inflammation and prematurity, Paris, France. FAU - Aires, Julio AU - Aires J AD - Universite Paris Cite, Inserm, FPRM, Faculte de Pharmacie de Paris, Paris, France. AD - FHU Prem'IMPACT Perinatal inflammation and prematurity, Paris, France. LA - eng PT - Journal Article PT - Review DEP - 20261023 PL - United States TA - Gut Microbes JT - Gut microbes JID - 101495343 RN - 0 (Receptors, Aryl Hydrocarbon) RN - 0 (Ligands) RN - 0 (Indoles) RN - C11E72455F (indole-3-carbinol) RN - 0 (Basic Helix-Loop-Helix Proteins) SB - IM MH - Humans MH - *Receptors, Aryl Hydrocarbon/metabolism/agonists/genetics MH - *Enterocolitis, Necrotizing/metabolism/drug therapy/microbiology MH - Ligands MH - Indoles/pharmacology/metabolism MH - Animals MH - Infant, Newborn MH - Infant, Premature MH - Signal Transduction MH - Gastrointestinal Microbiome MH - *Basic Helix-Loop-Helix Proteins/metabolism/agonists PMC - PMC13699851 OTO - NOTNLM OT - 3-indoleacrylic acid OT - Necrotizing enterocolitis OT - aryl hydrocarbon receptor OT - epithelial necroptosis OT - indole-3-carbinol OT - microbiota OT - prematurity OT - tryptophan metabolites COIS- No potential conflicts of interest were disclosed. EDAT- 2026/10/23 18:31 MHDA- 2026/10/23 18:32 PMCR- 2026/10/23 CRDT- 2026/10/23 13:33 PHST- 2026/10/23 18:32 [medline] PHST- 2026/10/23 18:31 [pubmed] PHST- 2026/10/23 13:33 [entrez] PHST- 2026/10/23 00:00 [pmc-release] AID - 2743958 [pii] AID - 10.1080/19490976.2026.2743958 [doi] PST - ppublish SO - Gut Microbes. 2026 Dec 31;18(1):2743958. doi: 10.1080/19490976.2026.2743958. Epub 2026 Oct 23. PMID- 42912045 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261024 IS - 1678-8060 (Electronic) IS - 0074-0276 (Print) IS - 0074-0276 (Linking) VI - 121 DP - 2026 TI - Application of image analysis in the evaluation of blood feeding by Lutzomyia longipalpis using an artificial feeding system with synthetic membranes. PG - e260065 LID - S0074-02762026000105053 [pii] LID - 10.1590/0074-02760260065 [doi] LID - e260065 AB - BACKGROUND: Blood feeding is essential for the maintenance of laboratory colonies and for experimental studies involving sand fly-parasite interactions. However, artificial feeding systems for Lutzomyia longipalpis, the principal vector of Leishmania infantum, the etiological agent of visceral leishmaniasis in the Americas, remain limited by low engorgement rates and methodological constraints in blood meal quantification. OBJECTIVES: This study evaluated the feeding performance of Lu. longipalpis on different membranes in an artificial feeder and applied an image-based approach to quantify blood meal size. METHODS: Females were fed either on anaesthetised hamsters (in vivo control) or using a Hemotek(R) artificial feeder equipped with chick skin (CHK), hydrated collagen membrane treated with plasma gel (COL+PG), or untreated hydrated collagen membrane (COL). Blood meal size was estimated through digital image analysis in Fiji/ImageJ using two regions of interest: whole abdomen area (AbdA) and red-coloured blood area (BldA). FINDINGS: Feeding rates were highest on live hosts (88.75%), followed by CHK (72.34%) and COL+PG (72.08%), whereas COL yielded significantly lower engorgement (54.67%). Although abdominal area was greater in females fed on hamsters, no significant differences in red-coloured area were detected among artificial membrane treatments. A strong positive correlation was observed between AbdA and BldA measurements (R(2) = 0.85), validating the image-based method. The use of plasma-treated collagen membranes achieved feeding rates comparable to CHK and was fully compatible with semi-automated image analysis. MAIN CONCLUSIONS: These findings demonstrate that hydrated collagen membranes treated with plasma gel constitute a viable and ethically preferable alternative to bird-derived membranes for the artificial feeding of Lu. longipalpis, while image analysis provides a precise, reproducible, and practical method for blood meal quantification. Collectively, this approach refines laboratory experiments Lu. longipalpis and enhances methodological reliability in studies of sand fly biology and vector-parasite interactions. FAU - Costa, Lidiane Medeiros da AU - Costa LMD AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. FAU - Sant'Anna, Mauricio Roberto Viana AU - Sant'Anna MRV AUID- ORCID: 0000-0002-2504-0979 AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. FAU - Vaz, Laura Aquino AU - Vaz LA AD - Pontificia Universidade Catolica de Minas Gerais, Belo Horizonte, MG, Brasil. FAU - Cruz, Geisler Peixoto da AU - Cruz GPD AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. FAU - Lara, Luisa de Melo AU - Lara LM AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. FAU - Paula, Gabriel Davi Medeiros de AU - Paula GDM AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. FAU - Araujo, Ricardo Nascimento AU - Araujo RN AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Artropodes Hematofagos, Belo Horizonte, MG, Brasil. FAU - Gontijo, Nelder de Figueiredo AU - Gontijo NF AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. FAU - Pereira, Marcos Horacio AU - Pereira MH AUID- ORCID: 0000-0003-4843-0088 AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. LA - eng PT - Journal Article DEP - 20261016 PL - Brazil TA - Mem Inst Oswaldo Cruz JT - Memorias do Instituto Oswaldo Cruz JID - 7502619 RN - 0 (Membranes, Artificial) RN - 9007-34-5 (Collagen) SB - IM MH - Animals MH - Female MH - *Psychodidae/physiology MH - *Feeding Behavior/physiology MH - *Membranes, Artificial MH - *Insect Vectors/physiology MH - *Image Processing, Computer-Assisted/methods MH - Cricetinae MH - Collagen PMC - PMC13673989 COIS- The authors declare that they have no conflict of interest. EDAT- 2026/10/23 18:31 MHDA- 2026/10/23 18:32 PMCR- 2026/10/16 CRDT- 2026/10/23 13:24 PHST- 2026/02/26 00:00 [received] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/10/23 18:32 [medline] PHST- 2026/10/23 18:31 [pubmed] PHST- 2026/10/23 13:24 [entrez] PHST- 2026/10/16 00:00 [pmc-release] AID - S0074-02762026000105053 [pii] AID - 10.1590/0074-02760260065 [doi] PST - epublish SO - Mem Inst Oswaldo Cruz. 2026 Oct 16;121:e260065. doi: 10.1590/0074-02760260065. eCollection 2026. PMID- 42911592 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261026 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 9 IP - 10 DP - 2026 Oct 1 TI - Emotion-Focused Behavioral Weight Loss Treatment for Adolescents: A Randomized Clinical Trial. PG - e2639867 LID - 10.1001/jamanetworkopen.2026.39867 [doi] LID - e2639867 AB - IMPORTANCE: Family-based behavioral treatment (FBT) efficacy decreases in adolescence, a developmental period of gradual maturation and increasing autonomy during which emotion regulation skills develop. OBJECTIVE: To evaluate the feasibility and efficacy of FBT alone compared with FBT plus emotion regulation across 6 months of treatment and 12 months of follow-up on adolescent weight change, emotion regulation, emotional eating, and parent weight change. DESIGN, SETTING, AND PARTICIPANTS: This parallel-group randomized clinical trial of adolescents 13 to 16 years of age with body mass index (BMI) in the 85th percentile or higher but less than the 99.9th percentile was conducted from August 29, 2019, to January 4, 2024, at 2 university clinics. Central randomization was completed by a statistician, and outcome assessors were blinded to treatment condition. The majority of treatments and assessments were delivered remotely via video conference due to the COVID-19 pandemic. INTERVENTIONS: FBT plus emotion regulation vs traditional FBT skills alone for weight loss. FBT included nutrition and physical activity education, behavior change strategies, and parenting skills. Both treatments had 6 months of adolescent and parent groups and behavior coaching sessions. The combined group included FBT skills and added dialectical behavior therapy and emotion-focused therapy. MAIN OUTCOMES AND MEASURES: The main outcomes were adolescent weight (body mass index [BMI] z score (BMIz) and BMI as a percentage of the 95th BMI percentile [%BMIp95]), emotion regulation skills (measured by Difficulties in Emotion Regulation Scale [DERS] scores), emotional eating behaviors (measured by Emotional Eating Scale [EES] scores), parent weight, and feasibility and acceptability of treatment. Primary outcome analyses used an intention-to-treat approach. RESULTS: A total of 166 (FBT plus emotion regulation = 84; FBT = 82) dyads (adolescents: mean [SD] age, 14.3 [1.2] years; 95 [57%] female; mean [SD] BMIz, 2.2 [0.6]; mean [SD] %BMIp95, 120.4 [21.4]; parents: mean [SD] age, 45.3 [6.5] years; 141 [85%] female; mean [SD] BMI, 32.6 [7.0]) were assessed at baseline, midtreatment, posttreatment, and 6- and 12-month follow-up visits. There were no statistically significant differences in posttreatment weight loss among adolescents receiving FBT plus emotion regulation compared with FBT (difference in BMIz, 0.03 [95% CI, -0.05 to 0.10]). However, adolescents in FBT plus emotion regulation did not regain as much weight at the 12-month follow-up (difference in BMIz, -0.09 [95% CI, -0.17 to -0.02]). At the 12-month follow-up, 4% (95% CI, 1%-12%) of adolescents in FBT and 22% (95% CI, 8%-48%) of adolescents in FBT plus emotion regulation lost a clinically significant amount of weight (>/=0.20 BMIz). At 12 months' follow-up, parent weight (difference in BMI, 0.51 [95% CI, -0.03 to 1.05]) and adolescent emotion regulation (difference in DERS scores, -0.06 [95% CI, -0.25 to 0.50]) did not differ by treatment. By contrast, the FBT plus emotion regulation group had lower scores than the FBT group on emotional eating (difference in EES scores, -0.39 [95% CI, -0.63 to -0.15]). CONCLUSIONS AND RELEVANCE: In this randomized clinical trial of 166 parent-adolescent dyads, adding emotion regulation skills to FBT did not improve weight loss during treatment but was associated with less weight regain and lower emotional eating through the 12-month follow-up. These findings suggest that adding emotion regulation skills to an FBT program may attenuate weight regain and decrease emotional eating among adolescents. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03674944. FAU - Boutelle, Kerri N AU - Boutelle KN AD - Department of Pediatrics, University of California, San Diego, La Jolla. AD - Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla. AD - Department of Psychiatry, University of California, San Diego. FAU - Manzano, Michael A AU - Manzano MA AD - Department of Psychiatry, University of California, San Diego. AD - San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego. FAU - Pasquale, Ellen K AU - Pasquale EK AD - Department of Psychiatry, University of California, San Diego. AD - San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, San Diego. FAU - Strong, David R AU - Strong DR AD - Herbert Wertheim School of Public Health and Human Longevity Science, University of California, San Diego, La Jolla. FAU - Bernard, Rebecca S AU - Bernard RS AD - Department of Pediatrics, University of California, San Diego, La Jolla. FAU - Rhee, Kyung E AU - Rhee KE AD - Department of Pediatrics, University of California, San Diego, La Jolla. FAU - Eichen, Dawn M AU - Eichen DM AD - Department of Pediatrics, University of California, San Diego, La Jolla. FAU - Miller, Alec AU - Miller A AD - Department of Psychiatry, Albert Einstein College of Medicine, White Plains, New York. FAU - Peterson, Carol B AU - Peterson CB AD - Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis. LA - eng SI - ClinicalTrials.gov/NCT03674944 PT - Journal Article PT - Randomized Controlled Trial DEP - 20261001 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - *Behavior Therapy/methods MH - Body Mass Index MH - *Emotional Eating MH - *Emotional Regulation MH - *Family Therapy/methods MH - *Pediatric Obesity/therapy/psychology MH - Treatment Outcome MH - *Weight Loss MH - *Weight Reduction Programs/methods PMC - PMC13691656 COIS- Conflict of Interest Disclosures: Drs Boutelle, Eichen, and Peterson reported receiving grants from the National Institutes of Health (NIH) during the conduct of the study. No other disclosures were reported. EDAT- 2026/10/23 18:31 MHDA- 2026/10/23 18:32 PMCR- 2026/10/22 CRDT- 2026/10/23 13:05 PHST- 2026/10/23 18:32 [medline] PHST- 2026/10/23 18:31 [pubmed] PHST- 2026/10/23 13:05 [entrez] PHST- 2026/10/22 00:00 [pmc-release] AID - 2855701 [pii] AID - zoi261080 [pii] AID - 10.1001/jamanetworkopen.2026.39867 [doi] PST - epublish SO - JAMA Netw Open. 2026 Oct 1;9(10):e2639867. doi: 10.1001/jamanetworkopen.2026.39867. PMID- 42910905 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261023 IS - 1536-7290 (Electronic) IS - 1536-7290 (Linking) VI - 26 IP - 11 DP - 2026 Nov TI - Age-Related Patterns of Relative Energy Deficiency in Sport (REDs) Symptoms and Key Performance Factors in Adolescent Biathletes. LID - e70273 [pii] LID - 10.1002/ejsc.70273 [doi] AB - Relative Energy Deficiency in Sport (REDs) impairs health and performance, but age-related patterns in its emergence remain unclear. This study examines RED symptoms in adolescent biathletes at season-start and their link to end-of-season performance. A national cross-sectional study including prospective performance registration recruited biathletes to complete validated questionnaires, followed by clinical interviews if eating disorders (EDs) were indicated. Athletes >/= 18 years were invited for physical laboratory assessments. End-of-season results were retrieved from open records. Analyses were performed by elastic net regression to identify the most stable predictors of performance, which were finally included in a linear regression model. Seventy-two athletes (55% females) with mean (SD) age 17.8 (1.4) years, 13.3 (3.3) training hours/week, and representing median (min, max) tier 3.0 (2, 5) were included. Prevalence in symptoms of low energy availability (LEA) was 18%, REDs 32%, EDs 11% (20% among females), and of depression 15%. Among 28 athletes (43% female) completing laboratory assessments, 11% had low BMD and /= 18 years who completed laboratory testing, 11% had low bone mineral density, and up to 25% showed clinical metabolic abnormalities. Symptoms of REDs and mental health concerns were more common in females and were more prevalent in the older age groups, peaking around 18 years. Better end-of-season performance was linked to higher training volume, fewer absences due to illness or injury, and lower RED severity. Higher body fat percentage and cholesterol levels were associated with poorer results. The findings highlight the importance of regular health screening, education and coaching to safeguard young athletes. OABL- eng OTO - NOTNLM OT - adolescent athletes OT - eating disorders OT - low energy availability OT - mental health OT - performance determinants EDAT- 2026/10/23 18:31 MHDA- 2026/10/23 18:32 CRDT- 2026/10/23 12:30 PHST- 2026/09/29 00:00 [revised] PHST- 2026/02/19 00:00 [received] PHST- 2026/10/03 00:00 [accepted] PHST- 2026/10/23 18:32 [medline] PHST- 2026/10/23 18:31 [pubmed] PHST- 2026/10/23 12:30 [entrez] AID - e70273 [pii] AID - 10.1002/ejsc.70273 [doi] PST - ppublish SO - Eur J Sport Sci. 2026 Nov;26(11):e70273. doi: 10.1002/ejsc.70273. PMID- 42910504 OWN - NLM STAT- Publisher LR - 20261023 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) DP - 2026 Oct 22 TI - Performance of a new regression equation for predicting energy expenditure and its potential for identifying dietary reference values for energy. PG - 1-14 LID - 10.1017/S0007114526108691 [doi] AB - The performance of a prediction equation for total energy expenditure (TEE), derived from a large database of doubly labelled water (DLW) measurements of TEE held at the International Atomic Energy Agency, which has been proposed for estimating population energy requirements (ER) from basic anthropometric data as a replacement for the factorial method, is tested against a dataset of 450 DLW-derived measures of TEE in randomly selected urban US adults aged 40-69 years, and its bias is evaluated. Its performance is also tested by modelling TEE for all ages at the healthy weights identified by the UK Scientific Advisory Committee on Nutrition, (SACN), in its report on dietary reference values (DRV) for energy, and the predicted values for TEE are compared with TEE calculated by the factorial method, as well as with values in a subsequent UK Government report on Dietary Recommendations for Energy, in which values for adolescents and for adults were capped at below their predicted values to help address issues of overweight and obesity. Whilst the prediction equation for TEE is accurate ( 0.7). Mean scores for all 18 items denoted no perceived influence, with 55.0-76.8% of respondents reporting no effect on their food-related attitudes and practices. Girls scored higher than boys for following nutrition-related content (p < 0.05) and for the increase in the desire to eat (p = 0.048); differences also emerged by place of residence (p = 0.041) and school attended (p = 0.008; p = 0.004). CONCLUSION: Adopted version of the SESMEB scale is a reliable instrument for assessing the perceived effects of social media on adolescent eating behavior. Most respondents reported no such influence, even though this population is intensively exposed to digital marketing of energy-dense products, suggesting that self-report may underestimate the actual effect of that exposure. CI - Copyright (c) 2026 Stojisavljevic, Jotic Ivanovic, Mijovic, Nikolic, Niskanovic and Joksimovic. FAU - Stojisavljevic, Dragana AU - Stojisavljevic D AD - Department of Nutrition, The Public Health Institute of Republic of Srpska, Banja Luka, Bosnia and Herzegovina. AD - Department of Public Health, Faculty of Medicine, University of Banja Luka, Banja Luka, Bosnia and Herzegovina. FAU - Jotic Ivanovic, Marina AU - Jotic Ivanovic M AD - Department of Family Medicine, Primary Health Care Centre, Doboj, Bosnia and Herzegovina. FAU - Mijovic, Biljana AU - Mijovic B AD - Department of Primary Health Care and Public Health, Faculty of Medicine, University of East Sarajevo, Foca, Bosnia and Herzegovina. FAU - Nikolic, Maja AU - Nikolic M AD - Department of Social Medicine, Faculty of Medicine, University of Nis, Nis, Serbia. FAU - Niskanovic, Jelena AU - Niskanovic J AD - Department of Psychology, Faculty of Philosophy, University of Banja Luka, Banja Luka, Bosnia and Herzegovina. FAU - Joksimovic, Bojan AU - Joksimovic B AD - Department of Preclinical Subjects (Pathological Physiology), Faculty of Medicine, University of East Sarajevo, Foca, Bosnia and Herzegovina. LA - eng PT - Journal Article DEP - 20261007 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13683706 OTO - NOTNLM OT - SESMEB questionnaire OT - adolescents OT - eating behavior OT - food marketing OT - social networks COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/23 11:32 MHDA- 2026/10/23 11:33 PMCR- 2026/10/07 CRDT- 2026/10/23 07:21 PHST- 2026/07/12 00:00 [received] PHST- 2026/09/07 00:00 [revised] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/10/23 11:33 [medline] PHST- 2026/10/23 11:32 [pubmed] PHST- 2026/10/23 07:21 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - 10.3389/fnut.2026.1935743 [doi] PST - epublish SO - Front Nutr. 2026 Oct 7;13:1935743. doi: 10.3389/fnut.2026.1935743. eCollection 2026. PMID- 42908925 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261023 LR - 20261024 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Feasibility of exercise training to address corticosteroid-induced changes in adolescents aged 10+ with lymphoma or leukemia during the first eight weeks of treatment: a pilot study. PG - 1819451 LID - 10.3389/fped.2026.1819451 [doi] LID - 1819451 AB - INTRODUCTION: Children and adolescents with hematological malignancies are at risk of adverse side effects from high-dose corticosteroid treatment during induction therapy. In this context, exercise and nutrition interventions are promising, physiologically grounded approaches but their feasibility and practical delivery during early intensive therapy remain unclear. Therefore, this prospective pilot randomized controlled trial was designed to evaluate the feasibility and preliminary effects of an exercise intervention and nutrition consultation in newly diagnosed patients. METHODS: Participants with leukemia or lymphoma, aged 10-17 years, were allocated to an 8-week exercise or sham control intervention (stratified randomization, 1:1 ratio, parallel groups) plus one-time nutrition counseling. Feasibility outcomes included recruitment, retention, adherence, safety, completion of assessments, and subjective feedback from patients and personnel involved in the study. Furthermore, repeated measures of physical performance, functional capacity, metabolic health, and body composition were used to explore baseline status and changes over time, after four and eight weeks of therapy. RESULTS: Six participants, two of which were allocated to the intervention group, completed the trial. Overall rates of consent (67%), training adherence (51%) and complete measures (70%) did not attain prespecified criteria (>/=80%). Despite considerable variability, pilot data indicated reduced physical capacity and functioning inferior to healthy norms at baseline and over the course of the intervention including hand grip strength (DeltaZ +/- SD = -1.5 +/- 1.4), cardiorespiratory fitness (steep ramp cycle ergometry peak power; DeltaZ +/- SD = -3.8 +/- 1.2), and lower extremity muscle strength (5-times sit-to-stand test; DeltaZ +/- SD = 2.3 +/- 2.0), while having mostly normal quadriceps muscle and abdominal fat thickness and erratic unfavorable metabolic states. No formal exploration of intervention effects was performed. DISCUSSION: Limited feasibility opposed continuation to a definite trial. Respective challenges observed may reflect particularities of early treatment, thus, substantial changes are advised for future protocols (e.g., towards a more adaptive trial design). Besides their limited generalizability and variability, pilot data suggests that adolescents undergoing induction therapy can experience intermittent deconditioning, while other outcomes were inconclusive. Thus, future exercise interventions should account for various objections to exercise participation, heterogeneous medical conditions, and potentially impaired physical capacity and functioning, especially during early therapy. CLINICAL TRIAL REGISTRATION: https://drks.de/search/de/trial/DRKS00032259, identifier DRKS00032259. CI - (c) 2026 Blumer, Erhard, Schanda, Tomaskovic and Dieckelmann. FAU - Blumer, Vera AU - Blumer V AD - Goethe University Frankfurt, Department of Pediatrics, Frankfurt (Main), Germany. FAU - Erhard, Sarah AU - Erhard S AD - Goethe University Frankfurt, Department of Pediatrics, Frankfurt (Main), Germany. FAU - Schanda, Nicola AU - Schanda N AD - Goethe University Frankfurt, Department of Pediatrics, Frankfurt (Main), Germany. FAU - Tomaskovic, Aleksandar AU - Tomaskovic A AD - Goethe University Frankfurt, Department of Pediatrics, Frankfurt (Main), Germany. FAU - Dieckelmann, Mirjam AU - Dieckelmann M AD - Goethe University Frankfurt, Department of Pediatrics, Frankfurt (Main), Germany. LA - eng PT - Clinical Trial PT - Journal Article DEP - 20261007 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13683610 OTO - NOTNLM OT - body composition OT - child OT - exercise therapy OT - leukemia OT - lymphoma OT - pediatric oncology OT - physical functioning OT - pilot study COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/23 11:32 MHDA- 2026/10/23 11:33 PMCR- 2026/10/07 CRDT- 2026/10/23 05:13 PHST- 2026/02/27 00:00 [received] PHST- 2026/08/31 00:00 [revised] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/10/23 11:33 [medline] PHST- 2026/10/23 11:32 [pubmed] PHST- 2026/10/23 05:13 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - 10.3389/fped.2026.1819451 [doi] PST - epublish SO - Front Pediatr. 2026 Oct 7;14:1819451. doi: 10.3389/fped.2026.1819451. eCollection 2026. PMID- 42908670 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261023 LR - 20261025 IS - 2773-0654 (Electronic) IS - 2773-0654 (Linking) VI - 5 IP - 6 DP - 2026 Dec TI - Beyond Accuracy: Machine Learning Models for Predicting the Presence of Permanent Molar Caries in U.S. Children and Adolescents With Fairness Consideration. PG - 100506 LID - 10.1016/j.focus.2026.100506 [doi] LID - 100506 AB - INTRODUCTION: Although predictors of dental caries have been previously explored, a comprehensive understanding of factors influencing permanent-molar decay in U.S. children and adolescents, especially with respect to racial and ethnic biases, remains limited. This study aims to develop and evaluate machine learning models incorporating algorithmic fairness to predict caries in permanent molars. METHODS: Data from the National Health and Nutrition Examination Survey were analyzed using the 2011-2014 cycles for training and validation and the 2015-2016 cycle for testing. The primary outcome was decayed, missing, and filled teeth in at least 1 permanent molar, dichotomized to represent the presence or absence of caries. Candidate predictors included demographic characteristics, dietary factors, laboratory and examination measures, behaviors, and lifestyle indicators. Three machine learning models (logistic regression, random forest, and XGBoost) were implemented and compared using the area under the receiver operating characteristic curve, accuracy, sensitivity, and specificity. Fairness was quantified by comparing group-specific true-positive rates and false-positive rates across race/ethnicity over 10 cross-validation folds, using Shapiro-Wilk tests and paired tests to assess subgroup gaps and pre/postmitigation changes. To mitigate disparities, an in-processing equalized-odds constraint was applied through an exponentiated-gradient reduction framework. Sensitivity analyses using National Health and Nutrition Examination Survey weights were also conducted. RESULTS: Among 5,710 participants aged 6-19 years, 37.30% had caries in at least 1 permanent molar. Logistic regression achieved the highest premitigation area under the receiver operating characteristic curve (78.50%). SHAP (SHapley Additive exPlanations) analyses identified age, family income, BMI, and household education as key contributors. Fairness evaluation indicated minimal equal-opportunity gaps but showed evidence of equalized-odds violations across race/ethnicity. After mitigation, race/ethnicity-related disparities decreased across models, with varying performance trade-offs. XGBoost and random forest maintained stable area under the receiver operating characteristic curve values in both unweighted ( approximately 77%-78%) and survey-weighted ( approximately 75%-77%) evaluations. In contrast, logistic regression showed a substantial decline in unweighted area under the receiver operating characteristic curve (78.50%-65.53%) and a marked reduction in recall and F1 score, whereas changes under weighted evaluation were more modest (77.91%-76.54%). CONCLUSIONS: Machine learning models effectively predicted dental caries in children and adolescents using National Health and Nutrition Examination Survey data. Applying equalized-odds constraints reduces disparities across models, although with varying fairness-performance trade-offs. These findings highlight the importance of tailoring bias mitigation strategies to clinical priorities, balancing equitable outcomes and predictive utility, and they can be used to inform policy and better design-targeted interventions to improve oral health. CI - (c) 2026 The Author(s). FAU - Deb, Pritam AU - Deb P AD - Department of Industrial and Systems Engineering, Kennesaw State University, Marietta, Georgia. FAU - Li, Lin AU - Li L AD - Department of Industrial and Systems Engineering, Kennesaw State University, Marietta, Georgia. FAU - Scherrer, Christina R AU - Scherrer CR AD - Department of Industrial and Systems Engineering, Kennesaw State University, Marietta, Georgia. LA - eng GR - R15 DE031428/DE/NIDCR NIH HHS/United States GR - R21 DE032149/DE/NIDCR NIH HHS/United States PT - Journal Article DEP - 20260509 PL - United States TA - AJPM Focus JT - AJPM focus JID - 9918487585606676 PMC - PMC13683022 OTO - NOTNLM OT - Dental caries OT - children and adolescents OT - fairness OT - machine learning OT - prediction EDAT- 2026/10/23 05:32 MHDA- 2026/10/23 05:33 PMCR- 2026/05/09 CRDT- 2026/10/23 02:36 PHST- 2026/10/23 05:33 [medline] PHST- 2026/10/23 05:32 [pubmed] PHST- 2026/10/23 02:36 [entrez] PHST- 2026/05/09 00:00 [pmc-release] AID - S2773-0654(26)00032-5 [pii] AID - 100506 [pii] AID - 10.1016/j.focus.2026.100506 [doi] PST - epublish SO - AJPM Focus. 2026 May 9;5(6):100506. doi: 10.1016/j.focus.2026.100506. eCollection 2026 Dec. PMID- 42908574 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261023 LR - 20261024 IS - 2399-3529 (Electronic) IS - 2399-3529 (Linking) VI - 2026 IP - 4 DP - 2026 TI - In vitro incubation of human sperm does not change DNA methylation. PG - hoag079 LID - 10.1093/hropen/hoag079 [doi] LID - hoag079 AB - STUDY QUESTION: Is DNA methylation in mature spermatozoa affected by different culture media? SUMMARY ANSWER: Incubation of mature spermatozoa in hydrogen peroxide (H(2)O(2)) or palmitate for 24 h did not alter the DNA methylome. WHAT IS KNOWN ALREADY: Children conceived through ART face a higher risk of disorders linked to abnormal DNA methylation. As culture media can modulate DNA methylation in somatic cells, abnormal DNA methylation after ART may be caused by factors present in culture media during sperm incubation. STUDY DESIGN SIZE DURATION: Sperm from four donors underwent targeted shotgun proteomics analysis, focusing on protein size ranges that include epigenetic modifying enzymes. Additionally, sperm samples from 15 men were incubated for 24 h in either standard media, media with H(2)O(2), or media containing palmitate, two media known to induce acute DNA methylation changes in somatic cells. DNA methylation profiles of these incubated sperm samples were then compared to those of pre-incubation sperm using Reduced Representation Bisulfite Sequencing (RRBS). PARTICIPANTS/MATERIALS SETTING METHODS: Sperm samples were obtained from 15 healthy Caucasian men aged 20-40 years. Participants using prescription medications daily or with a history of testicular disease were excluded. Motile sperm were isolated through the swim-up technique. Protein analysis was conducted via in-gel digestion followed by mass spectrometry. DNA methylation was evaluated using RRBS and validated for select genomic regions with targeted bisulfite pyrosequencing. MAIN RESULTS AND THE ROLE OF CHANCE: Proteomic analysis returned 1930 proteins, including 144 newly identified proteins. Consistent with previous studies, we confirmed the presence of DNA methyltransferase 1 (DNMT1), while de novo methyltransferases DNMT3A and DNMT3B were not detected. Incubation in control, H(2)O(2), and palmitate media all led to decreased sperm motility, with the decline occurring the fastest under the H(2)O(2) condition. Sperm DNA methylation remained unchanged across all three culture conditions. LARGE SCALE DATA: N/A. LIMITATIONS REASONS FOR CAUTION: RRBS analysis covers only a portion of the genome, so DNA methylation changes in unexamined regions cannot be excluded, particularly at repeated regions of the genome. Moreover, since this study tested only three culture media conditions, it remains possible that other media formulations could impact DNA methylation. WIDER IMPLICATIONS OF THE FINDINGS: This study indicates that the DNA methylome of mature human spermatozoa is stable despite the presence of DNA methylation machinery components. These results imply that DNA methylation changes in response to environmental stress are more likely to happen during earlier stages of spermatogenesis. While the various culture media used in ART are unlikely to alter the DNA methylation patterns of individual sperm cells, the possibility that certain sperm with specific methylation signatures are selectively favored cannot be ruled out. FUNDING: This work was supported by a Challenge Programme Grant from the Novo Nordisk Foundation (NNF18OC0033754) to the Gametic Epigenetics Consortium against Obesity (GECKO). The Novo Nordisk Foundation Center for Basic Metabolic Research is an independent research center at the University of Copenhagen, partially funded by an unrestricted donation from the Novo Nordisk Foundation (NNF18CC0034900). This work was supported by the French Government (National Research Agency, ANR) through the 'Investments for the Future' programs LABEX SIGNALIFE ANR-11-LABX-0028-01 and IDEX UCAJedi ANR-15-IDEX-01. DISCLOSURES: R.B. is a recipient of research funding granted by the Novo Nordisk Foundation. E.A. is a shareholder of ExSeed Health Ltd. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of European Society of Human Reproduction and Embryology. FAU - Kjoller, Emma Tykesson AU - Kjoller ET AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Dumargne, Marie-Charlotte AU - Dumargne MC AD - Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, Inserm and Universite Cote d'Azur, Valbonne, France. FAU - Ingerslev, Lars Roed AU - Ingerslev LR AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Manitta, Eleonora AU - Manitta E AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Dehestani, Yasmin AU - Dehestani Y AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Saupstad, Marte AU - Saupstad M AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Gonzalez-Franquesa, Alba AU - Gonzalez-Franquesa A AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Deshmukh, Atul Shahaji AU - Deshmukh AS AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Andersen, Emil AU - Andersen E AUID- ORCID: 0000-0001-6009-2099 AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. AD - ExSeed Health ApS, Copenhagen, Denmark. FAU - Barres, Romain AU - Barres R AUID- ORCID: 0000-0002-0158-519X AD - Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. AD - Institut de Pharmacologie Moleculaire et Cellulaire, CNRS, Inserm and Universite Cote d'Azur, Valbonne, France. LA - eng PT - Journal Article DEP - 20260911 PL - England TA - Hum Reprod Open JT - Human reproduction open JID - 101722764 PMC - PMC13682945 OTO - NOTNLM OT - ART OT - DNA methylation OT - bisulfite sequencing OT - epigenetics OT - spermatozoa EDAT- 2026/10/23 05:32 MHDA- 2026/10/23 05:33 PMCR- 2026/09/11 CRDT- 2026/10/23 01:13 PHST- 2025/11/17 00:00 [received] PHST- 2026/08/11 00:00 [revised] PHST- 2026/09/04 00:00 [accepted] PHST- 2026/10/23 05:33 [medline] PHST- 2026/10/23 05:32 [pubmed] PHST- 2026/10/23 01:13 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - hoag079 [pii] AID - 10.1093/hropen/hoag079 [doi] PST - epublish SO - Hum Reprod Open. 2026 Sep 11;2026(4):hoag079. doi: 10.1093/hropen/hoag079. eCollection 2026. PMID- 42908560 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261023 LR - 20261024 IS - 2633-4402 (Electronic) IS - 2633-4402 (Linking) VI - 6 DP - 2026 TI - Designing a context-specific intervention in practice: learning from a school-based physical activity intervention. PG - 78 LID - 10.3310/nihropenres.14336.2 [doi] LID - 78 AB - BACKGROUND: Public health interventions need to be designed for the intervention setting. Traditionally, to maximise internal validity, school-based pupil physical activity interventions deliver an identical programme across all settings. However, an interventions' success will depend on the context in which it is implemented, i.e. a schools' social, cultural, economic, environmental and other characteristics. In this paper we use the development of the PASSPORT (Physical Activity via a School-Specific PORTfolio) intervention as a case study for the development of context-specific public health interventions. We outline how we developed the intervention and draw out key learning from this for public health interventions generally. METHODS: The PASSPORT intervention takes a portfolio approach that allows schools to select and deliver tailored intervention content that is most suitable to their setting. The intervention was developed across multiple research steps that were designed to progressively build knowledge on school context and physical activity and integrate these into intervention design. We outline these in the paper. Formative studies include: a scoping review of intervention components; school staff interviews; a rapid ethnography; and a school survey. These findings informed the co-design of the intervention tool with primary school staff and the development of the portfolio content. Finally, we conducted a pilot study in two schools to learn from both the delivery of the intervention and associated evaluation data collection. KEY LEARNING: Key learning for context-specific intervention design has been gathered around four areas: Ground intervention design in a range of data and insight, Centre contextual experience, Design for intervention flexibility and user autonomy, and, Build in processes to test and iterate. CONCLUSIONS: Each of the formative studies and the intervention design steps provided parts of the complex picture of intervention context and design needs. Combined, the results of the studies supported the development of a context-specific intervention. CI - Copyright: (c) 2026 House D et al. FAU - House, Danielle AU - House D AUID- ORCID: 0000-0001-6171-9922 AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Howard, Abi AU - Howard A AUID- ORCID: 0009-0005-0613-3028 AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Kent-Saisch, Simona AU - Kent-Saisch S AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Porter, Alice AU - Porter A AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. AD - NIHR Bristol Biomedical Research Centre, Bristol, England, UK. FAU - Reid, Tom AU - Reid T AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Morbey, Roger AU - Morbey R AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Emm-Collison, Lydia AU - Emm-Collison L AD - Centre for Exercise, Nutrition & Health Sciences, University of Bristol, Bristol, England, UK. FAU - de Vocht, Frank AU - de Vocht F AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Salway, Ruth AU - Salway R AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. FAU - Jago, Russell AU - Jago R AUID- ORCID: 0000-0002-3394-0176 AD - Population Health Sciences, University of Bristol Medical School, Bristol, England, UK. AD - NIHR Bristol Biomedical Research Centre, Bristol, England, UK. LA - eng PT - Journal Article DEP - 20261008 PL - England TA - NIHR Open Res JT - NIHR open research JID - 9918333281906676 PMC - PMC13680835 OAB - WHAT THIS PAPER IS ABOUT: Programmes designed to support people's health need to be appropriate for the specific community they serve. For example, schools are a great place to support lots of children to be more active, but a programme needs to fit into the day-to-day life of a school for it to work well. Usually, health programmes are the same in each setting. But each setting is different, with different resources, people, equipment, and cultures. In this paper we describe how we designed a flexible programme that would be different in each school setting. We outline the steps we took to develop the programme and draw out key learning from this, to help other researchers who want to develop similar programmes. WHAT WE DID: We did several smaller projects to build up the information we needed to develop the flexible programme. These are described in the paper and include looking at current academic literature, doing interviews with school staff, spending lots of time in three schools, and doing a survey with many schools. We then took our learning from these projects to design the programme in workshops with school staff, and we used school knowledge and staff to develop the activities that make up the overall programme. We then tried out the intervention in two schools to learn from this. WHAT WE LEARNT: We learnt several key lessons that would be useful for other researchers who want to design a similar programme. 1) It was useful to have such a range of information to bring into the programme. 2) It was important to have the users, the people who would deliver the programme, at the centre of the programme development. 3) Designing the programme to be flexible was helpful, so that it could be different in each setting, and it was good for schools to be the decision-makers in this. 4) It was necessary to try out and improve the programme lots of times. OABL- eng OTO - NOTNLM OT - complex interventions OT - context OT - interventions OT - physical activity OT - public health OT - schools OT - settings COIS- No competing interests were disclosed. EDAT- 2026/10/23 05:32 MHDA- 2026/10/23 05:33 PMCR- 2026/10/08 CRDT- 2026/10/23 00:51 PHST- 2026/09/30 00:00 [accepted] PHST- 2026/10/23 05:33 [medline] PHST- 2026/10/23 05:32 [pubmed] PHST- 2026/10/23 00:51 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - 10.3310/nihropenres.14336.2 [doi] PST - epublish SO - NIHR Open Res. 2026 Oct 8;6:78. doi: 10.3310/nihropenres.14336.2. eCollection 2026. PMID- 42908542 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261024 IS - 1664-2295 (Electronic) IS - 1664-2295 (Linking) VI - 17 DP - 2026 TI - Psychiatric comorbidities in pediatric epilepsy: a single-center retrospective study highlighting the burden of depressive symptoms. PG - 1951989 LID - 10.3389/fneur.2026.1951989 [doi] LID - 1951989 AB - INTRODUCTION: Epilepsy in the pediatric population is frequently associated with psychiatric comorbidities. Depression is of particular clinical significance given its elevated incidence and substantial impact on quality of life, treatment adherence, and psychosocial functioning. The prevalence of depression in children with epilepsy ranges from 7% to 14%, considerably higher than the 1-5% reported in the general pediatric population. The relationship between epilepsy and depression appears bidirectional: epilepsy predisposes to depressive disorders, and depression may increase seizure risk, suggesting shared neurobiological pathways. This study aimed to assess the prevalence of psychiatric symptoms in pediatric patients with epilepsy, with particular focus on depressive symptomatology, and to examine associations with etiological and clinical variables. METHODS: This retrospective study included 240 pediatric patients (aged 2-18 years) diagnosed with epilepsy between 2013 and 2024. Psychiatric symptoms were ascertained retrospectively from clinical records. Patients were categorized into two groups: those with an identified genetic and/or structural abnormality (G1, n = 60) and those without (G2, n = 180). Statistical analysis employed the chi-squared test and Student's t-test (p < 0.05). RESULTS: Psychiatric symptoms were identified in 30% of patients (72/240, 95% CI 24.2-35.8%). The most prevalent disorder was attention-deficit/hyperactivity disorder (ADHD; n = 30), followed by sleep disturbance/asthenia (n = 19), aggression/temper tantrums (n = 13), depressive/mood symptoms (n = 11), anxiety symptoms (n = 10), autism spectrum disorder (n = 6), eating behavior alterations (n = 4), self-harm (n = 4), adjustment/self-esteem features (n = 3), obsessive-compulsive disorder (OCD; n = 3), panic attacks (n = 2), and suicide attempts (n = 2). Psychiatric symptoms were significantly more prevalent in G1 (42%, 95% CI 29.2-54.1%) than in G2 (26%, 95% CI 19.7-32.5%; p = 0.03), corresponding to an odds ratio of 2.02 (95% CI 1.10-3.72). No significant associations were found between psychiatric symptoms and age, sex, family history, or treatment regimen. DISCUSSION: Psychiatric comorbidities, including depressive symptomatology, are common in pediatric epilepsy and likely associated with underlying neurobiological factors. These findings support integrating neuropsychiatric screening, using validated instruments such as the Children's Depression Inventory-2 (CDI-2) and the Neurological Disorders Depression Inventory for Epilepsy-Youth version (NDDI-E-Y), into routine epilepsy care. CI - Copyright (c) 2026 De Leonardis, Spalice, Verrotti, De Rosa and Aloisio. FAU - De Leonardis, Arianna AU - De Leonardis A AD - Pediatric Neurology Unit, Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy. AD - Department of Pediatrics, University of Perugia, Perugia, Italy. FAU - Spalice, Alberto AU - Spalice A AD - Pediatric Neurology Unit, Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy. FAU - Verrotti, Alberto AU - Verrotti A AD - Department of Pediatrics, University of Perugia, Perugia, Italy. FAU - De Rosa, Isabella AU - De Rosa I AD - Pediatric Neurology Unit, Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy. FAU - Aloisio, Simone AU - Aloisio S AD - Pediatric Neurology Unit, Department of Maternal and Child Health and Urological Sciences, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy. LA - eng PT - Journal Article DEP - 20261007 PL - Switzerland TA - Front Neurol JT - Frontiers in neurology JID - 101546899 SB - IM MH - Humans MH - Child MH - Retrospective Studies MH - Female MH - *Epilepsy/epidemiology/psychology/complications MH - Male MH - Adolescent MH - Comorbidity MH - Child, Preschool MH - *Depression/epidemiology MH - Prevalence MH - Attention Deficit Disorder with Hyperactivity/epidemiology PMC - PMC13683009 OTO - NOTNLM OT - ADHD OT - depression OT - epilepsy OT - pediatrics OT - psychiatric comorbidity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors AS, AV declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/10/23 05:32 MHDA- 2026/10/23 05:33 PMCR- 2026/10/07 CRDT- 2026/10/23 00:36 PHST- 2026/07/29 00:00 [received] PHST- 2026/09/14 00:00 [revised] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/10/23 05:33 [medline] PHST- 2026/10/23 05:32 [pubmed] PHST- 2026/10/23 00:36 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - 10.3389/fneur.2026.1951989 [doi] PST - epublish SO - Front Neurol. 2026 Oct 7;17:1951989. doi: 10.3389/fneur.2026.1951989. eCollection 2026. PMID- 42907990 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261026 IS - 1471-230X (Electronic) IS - 1471-230X (Linking) VI - 26 IP - 1 DP - 2026 Jul 27 TI - Influencing factors and individualized intervention strategies for inadequate bowel preparation before colonoscopy in high-risk populations: a review based on the clinical practice of painless colonoscopy in China. LID - 10.1186/s12876-026-05161-1 [doi] LID - 688 AB - BACKGROUND: Inadequate bowel preparation (IBP) significantly reduces the diagnostic accuracy of painless colonoscopy and increases complication risks. High-risk populations account for 28% of painless colonoscopy cases in China, with IBP rates ranging from 42% to 62%, but targeted nursing interventions remain underdeveloped. OBJECTIVE: To systematically analyze IBP-related influencing factors and evaluate the effectiveness of individualized nursing interventions for high-risk populations undergoing painless colonoscopy in China. METHODS: Literature searches were conducted across the MEDLINE (via the PubMed interface, Cochrane Library, Embase, CNKI, Wanfang Data, and VIP from January 2020 to April 2024 using keywords related to bowel preparation, high-risk populations, and nursing intervention. Studies on Chinese high-risk populations undergoing painless colonoscopy were eligible if they reported IBP rate, bowel preparation score, or intervention adherence. RCTs, systematic reviews, and clinical guidelines were included. Two reviewers independently screened records, extracted data, and assessed methodological quality using the Cochrane Risk of Bias Tool, JBI Critical Appraisal Checklist, and AGREE II Instrument. Data synthesis involved descriptive analysis and random-effects meta-analysis. RESULTS: A total of 43 studies (32 RCTs, 7 systematic reviews, 4 guidelines) were included. Six high-risk populations were identified: obese patients (BMI >/= 28 kg/m(2)), patients with abdominal/pelvic surgery history, neurological disease patients, long-term medication users, children, and diabetic patients. Key influencing factors included gastrointestinal motility disorders, psychological anxiety, and medication interactions. Individualized interventions (e.g., dose-adjusted laxatives, nurse-led psychological counseling) reduced IBP rates by 23%-48% (pooled OR = 0.36, 95%CI:0.29-0.45, I(2)=45%). CONCLUSION: IBP in high-risk populations is driven by multi-dimensional factors. Context-adapted nursing interventions (e.g., WeChat-guided education, parental participation training) significantly improve preparation quality. Standardized protocols for primary hospitals and child-specific regimens are urgently needed. These findings translate into a risk-stratified, nurse-pharmacist-led preparation pathway that can be implemented immediately-especially in primary hospitals-to reduce IBP and improve safety. And these findings pertain to six high-risk populations-obese, post-surgical, neurological disease, long-term medication users, children, and diabetics-as predefined in the Introduction. CI - (c) 2026. The Author(s). FAU - Lai, Huibin AU - Lai H AD - The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang, 310009, China. FAU - Sun, Ting AU - Sun T AD - The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang, 310009, China. 1195037@zju.edu.cn. FAU - Yu, Xiujing AU - Yu X AD - The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, Zhejiang, 310009, China. 2187007@zju.edu.cn. LA - eng PT - Journal Article PT - Review PT - Systematic Review DEP - 20260727 PL - England TA - BMC Gastroenterol JT - BMC gastroenterology JID - 100968547 RN - 0 (Cathartics) SB - IM MH - Humans MH - China MH - *Colonoscopy/nursing/methods MH - *Cathartics/administration & dosage MH - Risk Factors MH - *Preoperative Care/nursing/methods PMC - PMC13688862 OTO - NOTNLM OT - Bowel Preparation OT - Colonoscopy OT - High-risk populations OT - Nursing Intervention OT - Systematic Review COIS- Declarations. Ethics approval and consent to participate: This study is a systematic review that synthesizes data from previously published studies (RCTs, systematic reviews, and guidelines). No original human subjects research was conducted, so formal ethical approval from an Institutional Review Board (IRB) or Approval Committee is not applicable. For the included primary studies (e.g., the 32 RCTs), informed consent from participants was obtained by the original study teams, as required by their respective IRB approvals. This systematic review did not involve direct interaction with human participants, and thus no additional consent to participate was needed. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/22 23:29 MHDA- 2026/10/22 23:30 PMCR- 2026/07/27 CRDT- 2026/10/22 22:36 PHST- 2025/10/14 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/10/22 23:30 [medline] PHST- 2026/10/22 23:29 [pubmed] PHST- 2026/10/22 22:36 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 10.1186/s12876-026-05161-1 [pii] AID - 5161 [pii] AID - 10.1186/s12876-026-05161-1 [doi] PST - epublish SO - BMC Gastroenterol. 2026 Jul 27;26(1):688. doi: 10.1186/s12876-026-05161-1. PMID- 42907746 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261024 IS - 1471-2334 (Electronic) IS - 1471-2334 (Linking) VI - 26 IP - 1 DP - 2026 Jul 24 TI - Perceived fatalism regarding possible COVID-19 infection and its association with self-reported comorbidities in 12 Latin American countries. LID - 10.1186/s12879-026-14042-7 [doi] LID - 1852 AB - INTRODUCTION: The COVID-19 pandemic has had substantial mental health consequences worldwide. However, evidence on perceived fatalism regarding possible COVID-19 infection, particularly in relation to self-reported comorbidities, remains limited in Latin America. OBJECTIVE: To assess perceived fatalism regarding possible COVID-19 infection and its association with self-reported comorbidities among participants recruited in 12 Latin American countries. METHODS: This multicenter analytical cross-sectional study used a non-probability online snowball sampling strategy from June to August 2020. The study included 6,530 participants from Peru, Chile, Paraguay, Mexico, Colombia, Bolivia, Panama, Ecuador, Costa Rica, El Salvador, Honduras, and Guatemala. Perceived fatalism was assessed using five items from a previously developed COVID-19 fatalism scale. The five-item overall score was the primary measure, whereas domain-specific analyses were considered exploratory because of their lower reliability. Self-reported respiratory disease, cardiac disease, diabetes mellitus, obesity, and other illnesses were analyzed as exposure variables. Adjusted prevalence ratios (aPRs) and 95% confidence intervals (CIs) were estimated using generalized linear models from the Poisson family with log link and robust variance. RESULTS: The median age was 22 years (IQR: 19-28), 58.8% of participants were female, 25.3% reported at least one comorbidity, and 55.0% of the sample was recruited in Peru. The five-item fatalism scale showed acceptable internal consistency (Cronbach's alpha = 0.707; McDonald's omega/Raykov's rho = 0.721). In adjusted models, high overall fatalism was more prevalent among participants reporting respiratory disease (aPR 1.17, 95% CI 1.05-1.30), cardiac disease (aPR 1.25, 95% CI 1.08-1.44), diabetes mellitus (aPR 1.32, 95% CI 1.09-1.61), obesity (aPR 1.23, 95% CI 1.10-1.37), and other illnesses (aPR 1.26, 95% CI 1.15-1.39). Men had a lower prevalence of high overall fatalism (aPR 0.88, 95% CI 0.83-0.94). Sensitivity analyses yielded materially similar estimates. CONCLUSIONS: In this non-probabilistic sample from 12 Latin American countries, self-reported comorbidities were associated with a modestly higher prevalence of perceived fatalism regarding possible COVID-19 infection. These findings should be interpreted as exploratory and hypothesis-generating, given the cross-sectional design, self-reported exposures, potential residual confounding, and the young, Peru-predominant, non-probability sample. They should not be interpreted as nationally representative estimates or as evidence of causal relationships. CI - (c) 2026. The Author(s). FAU - Mejia, Christian R AU - Mejia CR AUID- ORCID: 0000-0002-5940-7281 AD - Universidad de Huanuco, Huanuco, Peru. FAU - Vega-Useche, Camilo AU - Vega-Useche C AUID- ORCID: 0000-0002-7064-1765 AD - Fundacion Santa Fe de Bogota, Bogota, Colombia. acamilovega@gmail.com. AD - Universidad Pedagogica y Tecnologica de Colombia, Tunja, Colombia. acamilovega@gmail.com. FAU - Serna-Alarcon, Victor AU - Serna-Alarcon V AUID- ORCID: 0000-0002-9803-6217 AD - Universidad Privada Antenor Orrego, Piura, Peru. AD - Hospital de la Amistad Peru Corea Santa Rosa II-2, Piura, Peru. FAU - Cedillo-Balcazar, Jamil AU - Cedillo-Balcazar J AUID- ORCID: 0000-0003-1468-0628 AD - Direccion Provincial de Salud de Loja, Ministerio de Salud Publica, Loja, Ecuador. FAU - Chamorro-Espinoza, Scherlli E AU - Chamorro-Espinoza SE AUID- ORCID: 0000-0003-1412-3872 AD - Asociacion Medica de Investigacion y Servicios en Salud, Lima, Peru. FAU - Yanez, Jaime A AU - Yanez JA AUID- ORCID: 0000-0002-9713-1829 AD - Escuela de Posgrado, Universidad Internacional Iberoamericana, Campeche, Mexico. FAU - Davies, Neal M AU - Davies NM AUID- ORCID: 0000-0002-7050-1471 AD - University of Alberta, Edmonton, Canada. FAU - Useche-Villamizar, Dalia AU - Useche-Villamizar D AUID- ORCID: 0000-0003-0594-023X AD - Universidad Pedagogica y Tecnologica de Colombia, Tunja, Colombia. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260724 PL - England TA - BMC Infect Dis JT - BMC infectious diseases JID - 100968551 SB - IM MH - Humans MH - Female MH - *COVID-19/psychology/epidemiology/mortality MH - Male MH - Latin America/epidemiology MH - Cross-Sectional Studies MH - Adult MH - Self Report MH - Comorbidity MH - Middle Aged MH - Young Adult MH - SARS-CoV-2 MH - Adolescent MH - Aged PMC - PMC13688888 OTO - NOTNLM OT - COVID-19 OT - Comorbidity OT - Cross-sectional study OT - Fatalism OT - Latin America OT - Mental health COIS- Declarations. Ethics approval: This study was approved by the Research Bioethics Committee of Universidad Privada Antenor Orrego (Resolution No. 0237-2020-UPAO) and was conducted in accordance with the principles of the Declaration of Helsinki. Informed consent: Informed consent was obtained electronically from all individual participants included in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/10/22 23:29 MHDA- 2026/10/22 23:30 PMCR- 2026/07/24 CRDT- 2026/10/22 21:38 PHST- 2026/03/23 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/10/22 23:30 [medline] PHST- 2026/10/22 23:29 [pubmed] PHST- 2026/10/22 21:38 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - 10.1186/s12879-026-14042-7 [pii] AID - 14042 [pii] AID - 10.1186/s12879-026-14042-7 [doi] PST - epublish SO - BMC Infect Dis. 2026 Jul 24;26(1):1852. doi: 10.1186/s12879-026-14042-7. PMID- 42906735 OWN - NLM STAT- Publisher LR - 20261023 IS - 1873-6351 (Electronic) IS - 0278-6915 (Linking) VI - 219 DP - 2026 Oct 21 TI - Revisiting the obesogenic potential of legacy pollutants: Epidemiological, toxicogenomic, and benchmark dose-based evidence. PG - 116468 LID - S0278-6915(26)00543-0 [pii] LID - 10.1016/j.fct.2026.116468 [doi] AB - Legacy pollutants remain detectable in human populations despite decades of regulatory control, yet whether they continue to pose biologically relevant health risks under contemporary exposure scenarios remains unclear. Here we integrated epidemiology, toxicogenomics, and benchmark dose (BMD)-based risk assessment to re-evaluate the obesogenic potential of legacy pollutants in 665 adolescents. Among 97 quantified environmental chemicals in serum samples, hexachlorobenzene (HCB) and pentachlorophenol (PCP) were consistently identified as the principal contributors to overweight/obesity by generalized linear and weighted quantile sum models. Toxicogenomics, molecular docking, and adverse outcome pathway analyses indicate that both chemicals converge on endocrine and metabolic disruption and oxidative stress through key regulators including PPARgamma, INS, ESR1, TNF, and TP53. In vitro validation confirmed dose-dependent perturbations of obesity-related biomarkers, yielding biologically relevant points of departure through BMD modeling. Margin-of-exposure (MOE) analysis integrating these thresholds with human biomonitoring data revealed generally moderate-to-low risk for HCB, whereas approximately 4% of participants exhibited high-risk PCP exposure. These findings demonstrate that certain legacy pollutants remain biologically active and risk-relevant despite long-term regulation and highlight the value of integrating epidemiological evidence with mechanistic and quantitative toxicology for prioritizing chemicals of public health concern in the exposome era. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Li, Ming AU - Li M AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Health Effects of Environmental Pollution, Ministry of Ecology and Environment, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Cao, Yan AU - Cao Y AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Health Effects of Environmental Pollution, Ministry of Ecology and Environment, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Shi, Shiyu AU - Shi S AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Health Effects of Environmental Pollution, Ministry of Ecology and Environment, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Wu, Fan AU - Wu F AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Health Effects of Environmental Pollution, Ministry of Ecology and Environment, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Xie, Chang AU - Xie C AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Health Effects of Environmental Pollution, Ministry of Ecology and Environment, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. FAU - Song, Lulu AU - Song L AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. FAU - Wang, Youjie AU - Wang Y AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430030, China. FAU - Tao, Yun AU - Tao Y AD - Department of Obstetrics, Zhongnan Hospital of Wuhan University, 169, East Lake Road, Wuchang District, Wuhan, Hubei, 430071, China. Electronic address: taoyun@whu.edu.cn. FAU - Mei, Surong AU - Mei S AD - State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment and Health, Ministry of Education, Key Laboratory of Health Effects of Environmental Pollution, Ministry of Ecology and Environment, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, #13 Hangkong Road, Wuhan, Hubei, 430030, China. Electronic address: surongmei@hust.edu.cn. LA - eng PT - Journal Article DEP - 20261021 PL - England TA - Food Chem Toxicol JT - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JID - 8207483 SB - IM OTO - NOTNLM OT - Benchmark dose-based risk assessment OT - Environmental obesogens OT - Human biomonitoring OT - In silico approach OT - Legacy pollutants COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/22 23:29 MHDA- 2026/10/22 23:29 CRDT- 2026/10/22 19:55 PHST- 2026/08/21 00:00 [received] PHST- 2026/10/20 00:00 [revised] PHST- 2026/10/21 00:00 [accepted] PHST- 2026/10/22 23:29 [pubmed] PHST- 2026/10/22 23:29 [medline] PHST- 2026/10/22 19:55 [entrez] AID - S0278-6915(26)00543-0 [pii] AID - 10.1016/j.fct.2026.116468 [doi] PST - aheadofprint SO - Food Chem Toxicol. 2026 Oct 21;219:116468. doi: 10.1016/j.fct.2026.116468. PMID- 42906500 OWN - NLM STAT- Publisher LR - 20261022 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 270 DP - 2026 Oct 21 TI - Move or sit: Preschoolers' in-kindergarten physical activity and its association with fundamental motor skills using AI-assisted movement assessment. PG - 107976 LID - S0001-6918(26)01777-4 [pii] LID - 10.1016/j.actpsy.2026.107976 [doi] AB - This observational study examined physical activity (PA) across three kindergarten contexts and its association with fundamental motor skills (FMS), with a proprietary AI-assisted video/action-analysis tool used as a supplementary assessment aid. Fifty-seven children (61.11 +/- 12.73 months; range 45-81 months) from one kindergarten in Chengdu, China, were observed during morning exercise, organized physical education (PE), and free play using the Observational System for Recording Physical Activity in Children-Preschool Version (OSRAC-P); FMS were assessed with the standardized Fundamental Movement Skills Development Test for Children Aged 3-10 Years. The AI component was the proprietary "Xiaoneng Classmate" action-analysis platform developed by Chengdu Tixiaoneng Education Technology Co., Ltd.; manufacturer materials document AI-assisted action/video analysis and digital testing/data functions but do not disclose a public model architecture or study-specific validation metrics. Mean activity level was highest during morning exercise (3.29 +/- 0.09), followed by free play (2.94 +/- 0.40), and lowest during organized PE (2.46 +/- 0.26). Organized PE had the highest sedentary frequency (46.58% +/- 12.69%), whereas free play had the highest MVPA frequency (33.92% +/- 13.03%). To address multicollinearity in the original high-dimensional regression, parsimonious individual-level models adjusted for age, sex, and BMI and included MVPA during organized PE and free play. Organized-PE MVPA was positively associated with locomotor skill score (B = 0.471 per percentage point, HC3 SE = 0.141, beta = 0.407, 95% CI [0.187, 0.754], p = .002) and showed a weaker association with total FMS (B = 0.484, HC3 SE = 0.235, beta = 0.234, 95% CI [0.011, 0.957], p = .045); no PA predictor was significant for object-control or stability scores. Morning-exercise MVPA was not entered in the individual-level regression because it had no within-class variability. These findings are context-specific associations and do not establish causal direction. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Xu, Dongmiao AU - Xu D AD - School of Physical Education, Sichuan University, Chengdu, 610065, China. Electronic address: 2024227025001@stu.scu.edu.cn. FAU - Yang, Shunxiang AU - Yang S AD - Primary School Affillated to the Experimental High School of UESTC, Chengdu, 611730, China. Electronic address: shunxiangyang@163.com. FAU - Liu, Liu AU - Liu L AD - School of Physical Education, Sichuan University, Chengdu, 610065, China; School of Modern Service in Mianyang City College, Mianyang, 621000, China. Electronic address: liu_liu@scu.edu.cn. FAU - Gou, Jingpu AU - Gou J AD - College of Sports Training in Chengdu Sport University, Chengdu, 610041, China. Electronic address: guojingpu@sina.com. FAU - Zeng, Hongguang AU - Zeng H AD - School of Physical Education, Sichuan University, Chengdu, 610065, China. Electronic address: 570959086@qq.com. FAU - Liu, Liling AU - Liu L AD - School of Physical Education, Sichuan University, Chengdu, 610065, China. Electronic address: lilingliu0209@163.com. FAU - Zhu, Liangyu AU - Zhu L AD - School of Physical Education, Sichuan University, Chengdu, 610065, China. Electronic address: zly0621@scu.edu.cn. LA - eng PT - Journal Article DEP - 20261021 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM OTO - NOTNLM OT - AI-assisted movement assessment OT - Fundamental motor skills OT - OSRAC-P OT - Physical activity OT - Preschool children COIS- Declaration of competing interest The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/10/22 23:29 MHDA- 2026/10/22 23:29 CRDT- 2026/10/22 19:40 PHST- 2026/07/09 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/10/07 00:00 [accepted] PHST- 2026/10/22 23:29 [medline] PHST- 2026/10/22 23:29 [pubmed] PHST- 2026/10/22 19:40 [entrez] AID - S0001-6918(26)01777-4 [pii] AID - 10.1016/j.actpsy.2026.107976 [doi] PST - aheadofprint SO - Acta Psychol (Amst). 2026 Oct 21;270:107976. doi: 10.1016/j.actpsy.2026.107976. PMID- 42905624 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261024 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 10 DP - 2026 TI - Investigating the role of mental health and lifestyle behaviours in the risk of adolescent suicidal behaviours through machine learning. PG - e0358758 LID - 10.1371/journal.pone.0358758 [doi] LID - e0358758 AB - BACKGROUND: Suicidal behaviors among adolescents are a serious global public health concern and are closely linked to both mental health and everyday lifestyle behaviors. Suicidal ideation, planning, and attempts lie along a spectrum of increasing severity. However, how psychological distress and health-related behaviors interact to influence suicide risk is complex and not yet fully understood. This study aimed to identify key mental health and lifestyle factors associated with different stages of adolescent suicidal behaviors using interpretable machine learning methods. METHODS: Data were obtained from the 2021 Youth Risk Behavior Surveillance System (YRBS), a nationally representative survey of U.S. high school students. After data cleaning and multiple imputation, 16,946 adolescents aged 14-18 years were included in the analysis. Extreme Gradient Boosting (XGBoost) models were developed to predict suicidal ideation, suicide planning, and suicide attempts. Model performance was assessed using the area under the receiver operating characteristic curve (AUC) and related metrics. Feature importance was examined using gain-based measures, while SHapley Additive exPlanations (SHAP) and partial dependence plots were used to explore the direction, strength, and nonlinear effects of key predictors. RESULTS: All three XGBoost models showed satisfactory predictive performance. Mental health factors, particularly persistent feelings of sadness and self-rated mental health, were the strongest predictors across all stages of suicidal behaviors. Lifestyle behaviors, including sleep duration, physical activity, diet, screen time, and substance use, also contributed meaningfully to risk prediction, although their relative importance differed by outcome. SHAP analyses indicated that greater sadness and poorer mental health were strongly associated with higher suicide risk, whereas adequate sleep and higher levels of physical activity were associated with lower predicted risk. Substance use, including alcohol, cigarette, and marijuana use, played an important role in predicting suicide attempts than suicidal ideation or planning. Partial dependence analyses showed nonlinear and threshold effects, especially for sadness, mental health status, and sleep duration. CONCLUSION: Mental health factors, especially persistent sadness and overall psychological well-being, were among the most prominent factors associated with suicidal behaviors among adolescents, while lifestyle behaviors showed important and stage-specific associations. Interpretable machine learning approaches help identify complex and nonlinear patterns associated with adolescent suicide risk and offer valuable insights to guide targeted, evidence-based prevention efforts. CI - Copyright: (c) 2026 Ding, Lei. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Ding, Yanmei AU - Ding Y AD - Shanghai Civil Aviation College, Shanghai, China. FAU - Lei, Yanzhao AU - Lei Y AUID- ORCID: 0009-0002-4442-8327 AD - Shanghai SIPO Polytechnic, Shanghai, China. LA - eng PT - Journal Article DEP - 20261021 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adolescent MH - *Mental Health MH - *Life Style MH - Female MH - *Machine Learning MH - Male MH - *Suicide, Attempted/psychology/statistics & numerical data MH - *Adolescent Behavior/psychology MH - Boosting Machine Learning Algorithms MH - *Suicidal Ideation MH - Risk Factors MH - Predictive Learning Models MH - Risk-Taking PMC - PMC13686503 COIS- NO authors have competing interests. EDAT- 2026/10/22 23:29 MHDA- 2026/10/22 23:30 PMCR- 2026/10/21 CRDT- 2026/10/22 18:24 PHST- 2026/01/23 00:00 [received] PHST- 2026/09/03 00:00 [accepted] PHST- 2026/10/22 23:30 [medline] PHST- 2026/10/22 23:29 [pubmed] PHST- 2026/10/22 18:24 [entrez] PHST- 2026/10/21 00:00 [pmc-release] AID - PONE-D-26-03940 [pii] AID - 10.1371/journal.pone.0358758 [doi] PST - epublish SO - PLoS One. 2026 Oct 21;21(10):e0358758. doi: 10.1371/journal.pone.0358758. eCollection 2026. PMID- 42903657 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261023 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Retinoic acid signaling in growth plate development: receptor-specific effects, antagonist evidence, and pediatric translational considerations. PG - 1962290 LID - 10.3389/fendo.2026.1962290 [doi] LID - 1962290 AB - The growth plate is a spatially organized cartilage structure that drives longitudinal bone growth and is particularly vulnerable to nutritional imbalance, systemic disease, trauma, and drug exposure during childhood. Retinoic acid (RA), the bioactive metabolite of vitamin A, regulates transcription through retinoic acid receptors (RARalpha, RARbeta, and RARgamma). Its skeletal effects depend on concentration, developmental timing, tissue context, and receptor subtype. Physiologic RA homeostasis contributes to orderly chondrocyte maturation, whereas excessive or spatially inappropriate signaling can suppress proliferation, alter hypertrophic differentiation and extracellular matrix, and promote premature growth plate senescence or closure in experimental models. This narrative review integrates evidence on RA metabolism, RAR-dependent chondrocyte fate, and experimental RAR antagonists. Model-dependent antagonist effects include concurrent prevention of hedgehog inhibitor-associated closure and early post-injury attenuation of growth inhibition in juvenile mice; prevention during induction is not reversal of established physeal damage. Human zone-specific receptor biology remains insufficiently resolved, and apparently conflicting findings reflect differences in receptor pharmacology, tissue, developmental stage, timing, dose, and endpoint. Pediatric experience with systemic retinoids, including isotretinoin and the RARgamma agonist palovarotene, underscores the developmental hazards of pathway modulation. Future studies should prioritize validated human growth plate models, receptor-subtype pharmacology, and longitudinal skeletal monitoring. RAR antagonism remains a preclinical, hypothesis-generating strategy requiring rigorous dose-window and long-term safety evaluation before pediatric clinical investigation. CI - Copyright (c) 2026 Xing, Fan, Wang, Ma, Xuan and Zhang. FAU - Xing, Yutong AU - Xing Y AD - Department of Paediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. FAU - Fan, Ruiying AU - Fan R AD - Hebei University of Chinese Medicine, Shijiazhuang, Hebei, China. FAU - Wang, Kaixi AU - Wang K AD - Department of Paediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. FAU - Ma, Xinyu AU - Ma X AD - Department of Paediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. FAU - Xuan, Fan AU - Xuan F AD - Department of Paediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. FAU - Zhang, Huifeng AU - Zhang H AD - Department of Paediatrics, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. LA - eng PT - Journal Article PT - Review DEP - 20261006 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Receptors, Retinoic Acid) RN - 5688UTC01R (Tretinoin) RN - 0 (Retinoic Acid Receptor gamma) SB - IM MH - Humans MH - *Growth Plate/metabolism/growth & development/drug effects MH - Animals MH - *Receptors, Retinoic Acid/antagonists & inhibitors/metabolism MH - *Signal Transduction MH - *Tretinoin/metabolism MH - *Bone Development MH - Chondrocytes/metabolism MH - Translational Research, Biomedical MH - Child MH - Retinoic Acid Receptor gamma PMC - PMC13681268 OTO - NOTNLM OT - RAR antagonist OT - chondrocyte OT - endochondral ossification OT - epiphyseal closure OT - growth plate OT - pediatric growth OT - retinoic acid OT - retinoic acid receptor COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/22 17:33 MHDA- 2026/10/22 17:34 PMCR- 2026/10/06 CRDT- 2026/10/22 13:55 PHST- 2026/08/08 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/14 00:00 [accepted] PHST- 2026/10/22 17:34 [medline] PHST- 2026/10/22 17:33 [pubmed] PHST- 2026/10/22 13:55 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - 10.3389/fendo.2026.1962290 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Oct 6;17:1962290. doi: 10.3389/fendo.2026.1962290. eCollection 2026. PMID- 42903563 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261022 LR - 20261023 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Feeding practices during high-flow nasal cannula: current evidence and clinical implications for respiratory care. PG - 1948830 LID - 10.3389/fnut.2026.1948830 [doi] LID - 1948830 AB - High-flow nasal cannula (HFNC) therapy is increasingly used as a noninvasive respiratory support modality across acute and critical care settings. Although nutritional management is integral to the care of patients with respiratory failure, established guidelines for feeding patients receiving HFNC are lacking, and clinical decisions vary widely, reflecting persistent uncertainty about HFNC's effects on swallowing function, airway protection, and aspiration risk. This narrative review found that HFNC may alter swallowing biomechanics, particularly at flow rates >40 L/min, potentially increasing the risk of choking and aspiration. Evidence on aspiration risk is heterogeneous, deriving largely from healthy volunteers and pediatric bronchiolitis cohorts. Adult evidence is limited to retrospective studies; the largest found no increase in respiratory deterioration with enteral feeding. Most institutions lack formal feeding protocols, and practice is driven by individual clinician judgment. Areas of consensus include the safety of early enteral feeding in hemodynamically stable patients and the avoidance of routine prolonged withholding of nutrition based solely on HFNC use. Disagreement persists regarding routine swallowing assessment, optimal flow thresholds during feeding, and the prioritization of oral versus tube feeding. Safe feeding in patients receiving HFNC requires a multidisciplinary, individualized approach that balances respiratory support against nutritional adequacy. Prospective multicenter studies are needed to define safe flow thresholds, validate bedside assessment tools, and establish standardized feeding guidelines, particularly in adult and critically ill populations. CI - Copyright (c) 2026 Alqahtani, Alkhelb, Alamri, Alqahtani, Alshehri, Ghazwani, Almarkhan, Alqahtani, Alenezi, Aldhahir, Siraj, Alqarni, Alwafi, Almarkhan, Salem, Alrabeeah, Alanazi, Alamoudi and Alghamdi. FAU - Alqahtani, Jaber S AU - Alqahtani JS AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. AD - Research and Innovation Institute, Ministry of Defense Health Services, Riyadh, Saudi Arabia. FAU - Alkhelb, Jood AU - Alkhelb J AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Alamri, Alaa AU - Alamri A AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Alqahtani, Leen AU - Alqahtani L AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Alshehri, Razan AU - Alshehri R AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Ghazwani, Abdullah A AU - Ghazwani AA AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Almarkhan, Hussam M AU - Almarkhan HM AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Alqahtani, Ahmed S AU - Alqahtani AS AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Alenezi, Meshal H AU - Alenezi MH AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Aldhahir, Abdulelah M AU - Aldhahir AM AD - Respiratory Therapy Program, Department of Nursing, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia. FAU - Siraj, Rayan A AU - Siraj RA AD - Department of Respiratory Therapy, College of Applied Medical Sciences, King Faisal University, Al-Ahsa, Saudi Arabia. FAU - Alqarni, Abdullah A AU - Alqarni AA AD - Department of Respiratory Therapy, Faculty of Medical Rehabilitation Sciences, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Alwafi, Hassan AU - Alwafi H AD - Faculty of Medicine, Umm Al Qura University, Mecca, Saudi Arabia. FAU - Almarkhan, Sulaiman M AU - Almarkhan SM AD - King Fahad Military Medical Complex, Ministry of Defense Health Services, Dhahran, Saudi Arabia. FAU - Salem, Fahad A AU - Salem FA AD - King Fahad Military Medical Complex, Ministry of Defense Health Services, Dhahran, Saudi Arabia. FAU - Alrabeeah, Saad AU - Alrabeeah S AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Alanazi, Faisal R AU - Alanazi FR AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Alamoudi, Asma O AU - Alamoudi AO AD - Department of Respiratory Care, Prince Sultan Military College of Health Sciences, Dammam, Saudi Arabia. FAU - Alghamdi, Saeed M AU - Alghamdi SM AD - Clinical Technology Department, Respiratory Care Program, Faculty of Applied Medical Sciences, Umm Al-Qura University, Makkah, Saudi Arabia. LA - eng PT - Journal Article PT - Review DEP - 20261006 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13681048 OTO - NOTNLM OT - aspiration OT - deglutition disorders OT - enteral nutrition OT - feeding OT - high-flow nasal cannula OT - oxygen inhalation therapy OT - respiratory failure OT - respiratory insufficiency COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/22 17:33 MHDA- 2026/10/22 17:34 PMCR- 2026/10/06 CRDT- 2026/10/22 13:31 PHST- 2026/07/26 00:00 [received] PHST- 2026/09/09 00:00 [revised] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/10/22 17:34 [medline] PHST- 2026/10/22 17:33 [pubmed] PHST- 2026/10/22 13:31 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - 10.3389/fnut.2026.1948830 [doi] PST - epublish SO - Front Nutr. 2026 Oct 6;13:1948830. doi: 10.3389/fnut.2026.1948830. eCollection 2026. PMID- 42903521 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261022 LR - 20261023 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Gut microbiota dysbiosis in pediatric acute lymphoblastic leukemia: clinical consequences, mechanistic insights, and microbiota-targeted interventions. PG - 1928304 LID - 10.3389/fped.2026.1928304 [doi] LID - 1928304 AB - Gut microbiota dysbiosis has emerged as a key feature in pediatric acute lymphoblastic leukemia (ALL), driven by chemotherapy, antibiotic exposure, and treatment-related nutritional impairment. Increasing evidence indicates that disruption of microbial diversity and depletion of short-chain fatty acid-producing bacteria are closely associated with infectious complications, gastrointestinal toxicity, and potentially reduced treatment efficacy. This review synthesizes current evidence on the interplay between gut microbiota and pediatric ALL across four dimensions: clinical outcomes, treatment-related toxicity, pharmacological interactions, and prognosis. We further summarize how leukemia therapy reshapes microbial ecosystems through cytotoxic agents, antimicrobial exposure, and dietary alterations. In addition, we discuss microbiota-centered therapeutic strategies, including probiotics, prebiotics, synbiotics, postbiotics, dietary interventions, and fecal microbiota transplantation. While promising, these approaches require careful validation in pediatric oncology due to safety considerations and limited clinical trial data. Finally, we highlight methodological advances such as multi-omics integration and machine learning approaches, which may enable microbiome-based risk stratification and precision supportive care in the future. Overall, gut microbiota represents a potential modifiable factor influencing clinical outcomes in pediatric ALL. CI - (c) 2026 Chen, Li, Xing, Liu and Yang. FAU - Chen, Ke AU - Chen K AD - Department of Clinical Nutrition, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Li, Qingqing AU - Li Q AD - Department of Clinical Nutrition, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Xing, Yun AU - Xing Y AD - School of Chinese Medicine, Macau University of Science and Technology, Macau SAR, China. FAU - Liu, Changqi AU - Liu C AD - School of Exercise and Nutritional Sciences, San Diego State University, San Diego, CA, United States. FAU - Yang, Fei AU - Yang F AD - Department of Virtual Reality Technology, College of Digital Technology and Design, Chongqing Polytechnic University of Electronic Technology, Chongqing, China. LA - eng PT - Journal Article PT - Review DEP - 20261006 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13680964 OTO - NOTNLM OT - child OT - dysbiosis OT - gastrointestinal microbiome OT - leukemia OT - probiotics COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/22 17:33 MHDA- 2026/10/22 17:34 PMCR- 2026/10/06 CRDT- 2026/10/22 13:22 PHST- 2026/07/04 00:00 [received] PHST- 2026/09/06 00:00 [revised] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/10/22 17:34 [medline] PHST- 2026/10/22 17:33 [pubmed] PHST- 2026/10/22 13:22 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - 10.3389/fped.2026.1928304 [doi] PST - epublish SO - Front Pediatr. 2026 Oct 6;14:1928304. doi: 10.3389/fped.2026.1928304. eCollection 2026. PMID- 42903273 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261023 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Lion Hearts: applying implementation mapping to plan the delivery of a family-based physical activity intervention in community CrossFit affiliates. PG - 1970725 LID - 10.3389/fpubh.2026.1970725 [doi] LID - 1970725 AB - BACKGROUND: Community-based physical activity interventions face challenges in adoption, implementation, and sustainability. Lion Hearts is a family-based physical activity intervention designed to promote cardiovascular health among mothers and children aged 3-6 years. This study applied Implementation Mapping during intervention development to identify implementation determinants and develop stakeholder-informed strategies for subsequent pilot testing. METHODS: The five iterative tasks of Implementation Mapping were applied through a co-design process with seven CrossFit affiliate owner-coaches: (1) conducting an implementation needs and assets assessment and identifying adopters and implementers; (2) specifying implementation outcomes, performance objectives, determinants, and change objectives; (3) selecting theoretical change methods and implementation strategies; (4) producing implementation protocols and materials; and (5) developing a prospective implementation-evaluation plan. Two 60-min co-design sessions were conducted approximately eight weeks apart. The first elicited barriers and facilitators to adoption and delivery within affiliate settings. Audio recordings were transcribed verbatim, and three researchers reviewed and coded both transcripts using structured matrices, supplemented by facilitator notes. Findings were synthesized using rapid qualitative analysis and integrated with behavioral theory and implementation science frameworks to identify implementation determinants and develop implementation strategies and materials. This study applied the five tasks of Implementation Mapping to identify implementation determinants and develop stakeholder-informed strategies, delivery supports, and a prospective evaluation plan for subsequent pilot testing. RESULTS: Stakeholders identified implementation determinants related to coach knowledge and self-efficacy, participant engagement and competing demands, class structure and flow, scheduling, staffing, equipment availability, and compatibility with affiliate workflows. These findings informed implementation strategies and delivery supports targeting affiliate owners and coaches, including coach training resources, structured session templates, class-flow guidance, and fidelity-monitoring tools. Performance objectives and an implementation logic model were developed to specify hypothesized pathways linking determinants and strategies to prospective implementation outcomes. An evaluation plan was developed to assess reach, adoption, feasibility, acceptability, fidelity, and maintenance during subsequent pilot implementation. CONCLUSION: Implementation Mapping and stakeholder co-design produced a theory-informed, contextually responsive implementation package for Lion Hearts. Although implementation outcomes have not yet been evaluated, the resulting strategies, materials, and prospective evaluation plan are positioned for testing and refinement in community fitness settings. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, NCT07147387. CI - Copyright (c) 2026 Watkins, Goss, Mehls, Marshall, Dlugonski and Downs. FAU - Watkins, Janette AU - Watkins J AD - Department of Kinesiology, College of Health and Human Development, The Pennsylvania State University, University Park, PA, United States. FAU - Goss, Janelle AU - Goss J AD - Department of Kinesiology, College of Health and Human Development, The Pennsylvania State University, University Park, PA, United States. FAU - Mehls, Kelton AU - Mehls K AD - Department of Health and Human Development, University of Pittsburgh, Pittsburgh, PA, United States. FAU - Marshall, Ali AU - Marshall A AD - Department of Kinesiology, College of Health and Human Development, The Pennsylvania State University, University Park, PA, United States. FAU - Dlugonski, Deirdre AU - Dlugonski D AD - Department of Health & Clinical Sciences, College of Health Sciences, University of Kentucky, Lexington, KY, United States. FAU - Downs, Danielle Symons AU - Downs DS AD - Department of Kinesiology, College of Health and Human Development, The Pennsylvania State University, University Park, PA, United States. AD - Department of Obstetrics and Gynecology, College of Medicine, The Pennsylvania State University, University Park, PA, United States. LA - eng SI - ClinicalTrials.gov/NCT07147387 PT - Journal Article DEP - 20261006 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Exercise MH - Female MH - *Health Promotion/methods/organization & administration MH - Child MH - Child, Preschool MH - Prospective Studies MH - Program Evaluation MH - *Family MH - Mothers MH - Pilot Projects MH - Male PMC - PMC13680431 OTO - NOTNLM OT - community fitness OT - family-based intervention OT - implementation mapping OT - implementation strategies OT - maternal health OT - physical activity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/22 17:33 MHDA- 2026/10/22 17:34 PMCR- 2026/10/06 CRDT- 2026/10/22 11:51 PHST- 2026/08/17 00:00 [received] PHST- 2026/09/15 00:00 [revised] PHST- 2026/09/24 00:00 [accepted] PHST- 2026/10/22 17:34 [medline] PHST- 2026/10/22 17:33 [pubmed] PHST- 2026/10/22 11:51 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1970725 [doi] PST - epublish SO - Front Public Health. 2026 Oct 6;14:1970725. doi: 10.3389/fpubh.2026.1970725. eCollection 2026. PMID- 42902610 OWN - NLM STAT- Publisher LR - 20261021 IS - 1308-5735 (Electronic) DP - 2026 Oct 21 TI - Diagnostic Performance of Urinary Clusterin for Early Detection of Diabetic Kidney Disease in Pediatric Type 1 Diabetes Mellitus: A Case-Control Analysis. LID - 10.4274/jcrpe.galenos.2026.2026-4-1 [doi] AB - BACKGROUND: Urinary Clusterin, a glycoprotein linked to oxidative stress and tubular injury, is being evaluated as a more sensitive biomarker for diabetic kidney disease (DKD). This study aims to assess the role of Clusterin in the early detection and prognostication of diabetic kidney disease in children with Type 1 Diabetes Mellitus (T1DM), addressing a critical gap in pediatric clinical data. METHODS: This case-control study at Beni-Suef University compared 50 children with T1DM (duration >/=5 years) to 40 healthy controls. Assessments included Body Mass Index (BMI), glycated hemoglobin (HbA1c), and lipid profiles. Urinary Clusterin was measured using Enzyme Linked Immunosorbent Assay (ELISA). A Receiver Operating Characteristic (ROC) curve analysis was employed to determine the diagnostic performance of urinary Clusterin in detecting diabetic nephropathy. RESULTS: Diabetic cases exhibited significantly higher levels of AST, cholesterol, triglycerides, and serum creatinine compared to the control group. The urinary profile revealed significantly elevated urinary creatinine, albumin, and albumin-to-creatinine ratios in cases, with urinary clusterin levels being significantly higher in children with diabetes (49.7 vs. 32.3 pg/mL, p<0.001) than in healthy controls. Within the case group, urinary clusterin significantly correlated with ALT, serum creatinine, and triglycerides, although no significant associations were found with age, BMI, or HbA1c. At a cutoff value of 37.6 pg/mL, urinary clusterin is a highly effective marker for early detection of diabetic nephropathy with an 80% sensitivity, and 90% specificity. CONCLUSION: Urinary clusterin is a potential non-invasive biomarker for early diabetic nephropathy in children with T1DM, outperforming traditional measures and offering a promising tool for earlier screening and improved clinical management. FAU - Hasan, Mennat Allah Taha AU - Hasan MAT AD - Department Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt. FAU - Fahmey, Sameh S AU - Fahmey SS AD - Department Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt. FAU - Ewas, Howaida Khairy AU - Ewas HK AUID- ORCID: 0000-0001-6362-7183 AD - Department Pediatrics, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt. LA - eng PT - Journal Article DEP - 20261021 PL - Turkey TA - J Clin Res Pediatr Endocrinol JT - Journal of clinical research in pediatric endocrinology JID - 101519456 SB - IM OTO - NOTNLM OT - Apolipoprotein J OT - Diabetic Kidney Disease OT - Type 1 Diabetes Mellitus OT - Urinary Clusterin EDAT- 2026/10/21 11:28 MHDA- 2026/10/21 11:28 CRDT- 2026/10/21 09:27 PHST- 2026/10/21 11:28 [medline] PHST- 2026/10/21 11:28 [pubmed] PHST- 2026/10/21 09:27 [entrez] AID - 10.4274/jcrpe.galenos.2026.2026-4-1 [doi] PST - aheadofprint SO - J Clin Res Pediatr Endocrinol. 2026 Oct 21. doi: 10.4274/jcrpe.galenos.2026.2026-4-1. PMID- 42902300 OWN - NLM STAT- MEDLINE DCOM- 20261021 LR - 20261023 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 23 TI - Retrospective cross-sectional study of clinical and laboratory profiles of paediatric tuberculosis at Ayder Comprehensive Specialized Hospital, Ethiopia (2018-2021). LID - 10.1186/s12887-026-07391-4 [doi] LID - 1029 AB - BACKGROUND: Pediatric Tuberculosis (TB) remains a diagnostic challenge owing to its paucibacillary nature and diverse clinical presentation. We aimed to characterise the clinical pattern, diagnostic yields, and predictors of disease forms among children managed at Ayder Comprehensive Specialized Hospital (ACSH), Mekelle, Ethiopia. OBJECTIVE: To describe the disease form distribution, clinical features, and laboratory profiles of pediatric tuberculosis at a tertiary Ethiopian hospital, and to identify independent predictors of extrapulmonary and disseminated disease using multivariable logistic regression. METHODS: We conducted an institution-based, retrospective analytical cross-sectional study of 123 children (< 18) diagnosed with TB at ACSH between May 2018 and April 2021. From 180 screened charts, we excluded 57 cases (prior treatment n = 27, incomplete records n = 20, insufficient evidence n = 10). Using validated data extraction checklist, we analysed sociodemographics, clinical presentation, nutritional status, comorbidities, laboratory results (GeneXpert, ESR, haemoglobin), and TB disease forms via SPSS version 23, applying bivariable and multivariable logistic regression. RESULTS: The mean age was 8.8 +/- 5.3 years; adolescents (11-17 years) comprised 42.3% (n = 52). Females were slightly predominant (52%). Common presenting symptoms included fever (78%), weight loss (71.5%), and cough (55.5%). Severe acute malnutrition (SAM) affected 37.7% (n = 40/106), with the highest burden in children aged < 5 years (45.7%). Anaemia was prevalent in 62.7% (n = 74/118); ESR was elevated in 84% (n = 89/106). Extrapulmonary TB (EPTB) was the most common form (43.9%; 95% CI 35.2-52.9). GeneXpert positivity was 31.3%. Younger age was significantly associated with EPTB (p < 0.001); children aged 0-4 years had over 3.5 times higher odds of EPTB compared with adolescents (AOR 3.57; 95% CI 1.28-10.00; p = 0.015). CONCLUSION: Paediatric TB in this referral setting is characterised by high rates of extrapulmonary and disseminated disease, severe malnutrition, and low bacteriological confirmation. Younger age was independently associated with disease dissemination, a finding consistent with the immunological characteristics of early childhood. Early, age-stratified screening and adoption of more sensitive diagnostic tools are urgently needed in similar high-burden settings. CI - (c) 2026. The Author(s). FAU - Girmay, Tekae Gebru AU - Girmay TG AD - Department of Pediatrics and Child health, School of Medicine, College of Medicine and health science, Mekelle University, Mekelle, Ethiopia. FAU - Gossaye, Tariku Yigremachew AU - Gossaye TY AUID- ORCID: 0009-0001-8137-1908 AD - Department of Pediatrics and Child health, College of Medicine and Health Science, Mizan Tepi University, Mizan Aman, Ethiopia. Tarikuyigremachew@gmail.com. FAU - Gebrihiet, Haftu Hailu AU - Gebrihiet HH AD - Department of Pediatrics and Child health, College of Medicine and Health science, Mekelle University, Mekelle, Ethiopia. FAU - Tsegay, Niguse AU - Tsegay N AD - Department of Pediatrics and Child health, College of Medicine and Health science, Mekelle University, Mekelle, Ethiopia. LA - eng PT - Journal Article DEP - 20260723 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Female MH - Ethiopia/epidemiology MH - Cross-Sectional Studies MH - Child MH - Male MH - Retrospective Studies MH - Adolescent MH - Tuberculosis, Extrapulmonary MH - *Tuberculosis/diagnosis/epidemiology MH - Child, Preschool MH - Infant PMC - PMC13685323 OTO - NOTNLM OT - Clinical profile OT - Diagnostic challenges OT - Ethiopia OT - Extrapulmonary TB OT - Paediatric tuberculosis COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance the declaration of Helsinki. Ethical approval was obtained from Institutional Review Board (IRB) of the College of Health Sciences of Mekelle University (Reference No: MU-IRB/1864/21). Permission from Ayder Comprehensive Specialized Hospital clinical director offices, support letter from chief clinical director obtained before the commencement of the study. Because this was retrospective chart review involving minimal risk to the participants, the requirement for informed consent from the parents or legal guardian of minors was formally waived by Mekelle University IRB. All patients' data were handled with strict confidentiality and were anonymized prior to Analysis. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/21 05:32 MHDA- 2026/10/21 05:33 PMCR- 2026/07/23 CRDT- 2026/10/21 00:43 PHST- 2026/03/16 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/10/21 05:33 [medline] PHST- 2026/10/21 05:32 [pubmed] PHST- 2026/10/21 00:43 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - 10.1186/s12887-026-07391-4 [pii] AID - 7391 [pii] AID - 10.1186/s12887-026-07391-4 [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 23;26(1):1029. doi: 10.1186/s12887-026-07391-4. PMID- 42901802 OWN - NLM STAT- Publisher LR - 20261020 IS - 1532-5040 (Electronic) IS - 0959-3985 (Linking) DP - 2026 Oct 20 TI - Cardiopulmonary exercise testing in children with cerebral palsy: Feasibility and the relationship between aerobic capacity and gross motor function: A pilot study. PG - 1-10 LID - 10.1080/09593985.2026.2751571 [doi] AB - INTRODUCTION: Children with cerebral palsy (CP) may exhibit reduced aerobic capacity. While the cardiopulmonary exercise test (CPET) is the gold standard for determining aerobic capacity, motor disorders and accompanying disturbances make its application challenging. The 6-minute walk test (6-MWT) may offer a practical alternative. OBJECTIVE: To evaluate the feasibility of CPET, explore its relationship with the 6-MWT, and investigate the association between aerobic capacity and gross motor function in children with CP. METHODS: Children aged 6-13 years with unilateral/bilateral spastic CP classified as Gross Motor Function Classification System Level II, who could follow instructions and walk on a treadmill without physical assistance, were included. The Gross Motor Function Measure-88 (GMFM-88), 6-MWT, and treadmill-based CPET were performed. CPET feasibility was evaluated by maximal exertion and termination reasons. RESULTS: Eight participants (four males, four females; four spastic unilateral, four spastic bilateral) with a median age of 8.5 years were enrolled. The median (minimum-maximum) peak oxygen consumption (VO(2peak)), respiratory exchange ratio (RER), and maximum heart rate (HR(max)) in CPET were 21 (17.1-30.6) mL/kg/min, 0.87 (0.81-1.00), and 145.5 (97-174) bpm, respectively. One participant achieved near-maximal exertion during CPET, while the others demonstrated submaximal effort. Reasons for CPET termination included lower limb fatigue (n = 5) and poor compliance (n = 3). The 6-minute walk distance (6MWD) was not significantly correlated with VO(2peak) (r = 0.000, p > .999). 6MWD was strongly correlated with the GMFM-88 total score (r = 0.790, p = .020). Moderate correlations, which were not statistically significant, were found between 6MWD and the GMFM-88 Dimensions D (r = 0.672, p = .068) and E (r = 0.695, p = .056). No significant correlations were observed between the GMFM-88 scores and VO(2peak), RER, or HR(max). CONCLUSION: Treadmill-based CPET demonstrated limitations in reaching maximal aerobic capacity in this pilot sample of children with CP. The 6-MWT may offer a practical approach for evaluating functional performance, given its association with gross motor function. FAU - Ozdemir Tekes, Sevgi Esra AU - Ozdemir Tekes SE AUID- ORCID: 0009-0006-9272-4840 AD - Department of Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey. FAU - Turan, Burak Kamil AU - Turan BK AUID- ORCID: 0000-0002-4382-9463 AD - Department of Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey. FAU - Kutlay, Sehim AU - Kutlay S AUID- ORCID: 0000-0002-6869-6070 AD - Department of Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey. FAU - Sonel Tur, Birkan AU - Sonel Tur B AUID- ORCID: 0000-0002-0798-4554 AD - Department of Physical Medicine and Rehabilitation, Ankara University Faculty of Medicine, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20261020 PL - England TA - Physiother Theory Pract JT - Physiotherapy theory and practice JID - 9015520 SB - IM OTO - NOTNLM OT - 6-minute walk test OT - cardiopulmonary exercise test OT - cerebral palsy OT - exercise tolerance OT - gross motor function EDAT- 2026/10/20 23:29 MHDA- 2026/10/20 23:29 CRDT- 2026/10/20 21:53 PHST- 2026/10/20 23:29 [medline] PHST- 2026/10/20 23:29 [pubmed] PHST- 2026/10/20 21:53 [entrez] AID - 10.1080/09593985.2026.2751571 [doi] PST - aheadofprint SO - Physiother Theory Pract. 2026 Oct 20:1-10. doi: 10.1080/09593985.2026.2751571. PMID- 42900350 OWN - NLM STAT- Publisher LR - 20261020 IS - 1933-7205 (Electronic) IS - 1933-7191 (Linking) DP - 2026 Oct 20 TI - Roles and Biological Effects of Polysaccharides in Polycystic Ovary Syndrome: A Narrative Review. LID - 10.1007/s43032-026-02232-2 [doi] AB - Polycystic ovary syndrome (PCOS) represents a prevalent and clinically significant reproductive-endocrine disorder among women of childbearing age. While dietary interventions, regular physical activity, and targeted lifestyle modifications have been validated to confer therapeutic benefits for PCOS management, polysaccharides key bioactive components of higher plants with extensive distribution throughout the plant and animal kingdoms exhibit distinct pleiotropic bioactivities, including anti-inflammatory, immunomodulatory, hypoglycemic, lipid-lowering, and anti-obesogenic properties. In the context of PCOS treatment, these natural macromolecules hold considerable promise for alleviating clinical manifestations, ameliorating insulin resistance and obesity, attenuating inflammatory responses, and restoring sex hormone homeostasis. Cumulative evidence from preclinical and clinical studies has demonstrated that polysaccharides can improve menstrual irregularities, reduce body weight, lower blood glucose and serum testosterone levels, and suppress aberrant inflammation. The present review systematically summarizes the multifaceted effects of diverse polysaccharide compounds on PCOS, aiming to provide insights into their potential as complementary therapeutic agents for this complex disorder. CI - (c) 2026. The Author(s), under exclusive licence to Society for Reproductive Investigation. FAU - Ding, Ning AU - Ding N AD - Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China. FAU - Sun, Chang AU - Sun C AD - Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China. FAU - Wang, Haotian AU - Wang H AD - Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China. FAU - Lv, Yingchun AU - Lv Y AD - Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China. FAU - Han, Yanhua AU - Han Y AD - The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China. FAU - Kuang, Hongying AU - Kuang H AUID- ORCID: 0009-0008-6885-7445 AD - The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang, China. 949304685@qq.com. LA - eng GR - 82374509，82174422/National Natural Science Foundation of China/ GR - 2022CYCX0026/Longjiang Science and Technology Talent Spring Swan Support Program/ GR - LH2023H062/Natural Science Foundation of Heilongjiang Province/ GR - FCK-ZSYTW-08/China Special Research Fund for Obstetrics and Gynecology of Integrated Traditional Chinese and Western Medicine/ PT - Journal Article PT - Review DEP - 20261020 PL - United States TA - Reprod Sci JT - Reproductive sciences (Thousand Oaks, Calif.) JID - 101291249 SB - IM OTO - NOTNLM OT - Astragalus polysaccharides OT - Inulin OT - PCOS OT - Polysaccharides OT - Poria polysaccharides COIS- Declarations. Consent for Publication: Not applicable. Ethics Approval: Not applicable. Consent to Participate: Not applicable. Competing Interests: The authors declare no competing interests. EDAT- 2026/10/20 17:34 MHDA- 2026/10/20 17:34 CRDT- 2026/10/20 14:46 PHST- 2026/01/08 00:00 [received] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/20 17:34 [medline] PHST- 2026/10/20 17:34 [pubmed] PHST- 2026/10/20 14:46 [entrez] AID - 10.1007/s43032-026-02232-2 [pii] AID - 10.1007/s43032-026-02232-2 [doi] PST - aheadofprint SO - Reprod Sci. 2026 Oct 20. doi: 10.1007/s43032-026-02232-2. PMID- 42899151 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261020 LR - 20261022 IS - 2590-1575 (Electronic) IS - 2590-1575 (Linking) VI - 39 DP - 2026 Oct TI - Goat and cow milk merits distinct nutritional and functional properties based on simulated gastrointestinal digestion of infant. PG - 104582 LID - 10.1016/j.fochx.2026.104582 [doi] LID - 104582 AB - The nutritional and functional properties of goat and cow milk in digestive tract of infant is unclear. Applying simulated infant gastrointestinal digestion method, this study aims to systematically compare digestibility, peptide profiling, and immunomodulatory role of goat and cow milk, and further characterize their role in regulating homeostasis of gut microbiota and metabolism. It's found that the degree of hydrolysis and number of detected peptides was higher in goat milk (GM), while the relative abundance of predicted allergic peptides was higher in cow milk (CM). In addition, the expression of IL-1beta and/or IL-6 in colonic organoids was elevated after GM or CM digesta intervention. Furthermore, GM and CM showed distinct effects on the composition of gut microbiota and metabolite profiles in an in vitro hindgut fermentation system using infant fecal inocula. The results provide basis for future applications of GM and CM in infant feeding, and further validation is required. CI - (c) 2026 The Authors. FAU - Chen, Jiaxin AU - Chen J AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. AD - College of Animal Science, Shanxi Agricultural University, Taigu 030800, China. FAU - Zhu, Ruikai AU - Zhu R AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. FAU - Wu, Linjun AU - Wu L AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. FAU - Kuang, Jian AU - Kuang J AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. FAU - Bian, Xiangyu AU - Bian X AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. FAU - Li, Xiaoqiong AU - Li X AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. FAU - Wang, Weiwei AU - Wang W AD - College of Animal Science, Shanxi Agricultural University, Taigu 030800, China. FAU - Kang, Wenjie AU - Kang W AD - Yeeper (Qingdao) Sheep Dairy Co., LTD., Qingdao 266000, China. AD - Yeeper (Qingdao) Hypoallergenic Nutritional Research Institute, Qingdao 266000, China. FAU - Mu, Shanbo AU - Mu S AD - Yeeper (Qingdao) Sheep Dairy Co., LTD., Qingdao 266000, China. AD - Yeeper (Qingdao) Hypoallergenic Nutritional Research Institute, Qingdao 266000, China. FAU - Liu, Bryan Yanwen AU - Liu BY AD - Yeeper (Qingdao) Hypoallergenic Nutritional Research Institute, Qingdao 266000, China. AD - College of Biotechnology, East China University of Science and Technology, Shanghai 200237, China. AD - Key Laboratory of Microbial Physiology and Metabolism, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. FAU - Zhao, Ke AU - Zhao K AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. FAU - Li, Jinjun AU - Li J AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou 310021, China. LA - eng PT - Journal Article DEP - 20261007 PL - Netherlands TA - Food Chem X JT - Food chemistry: X JID - 101751436 PMC - PMC13679301 OTO - NOTNLM OT - Cow milk OT - Goat milk OT - Gut microbiota OT - Infant OT - Metabolites OT - Peptides OT - Simulated gastrointestinal digestion COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/20 18:32 MHDA- 2026/10/20 18:33 PMCR- 2026/10/07 CRDT- 2026/10/20 12:52 PHST- 2026/04/19 00:00 [received] PHST- 2026/10/04 00:00 [revised] PHST- 2026/10/05 00:00 [accepted] PHST- 2026/10/20 18:33 [medline] PHST- 2026/10/20 18:32 [pubmed] PHST- 2026/10/20 12:52 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - S2590-1575(26)01103-X [pii] AID - 104582 [pii] AID - 10.1016/j.fochx.2026.104582 [doi] PST - epublish SO - Food Chem X. 2026 Oct 7;39:104582. doi: 10.1016/j.fochx.2026.104582. eCollection 2026 Oct. PMID- 42898497 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261020 LR - 20261022 IS - 2667-3681 (Electronic) IS - 2667-3681 (Linking) VI - 20 DP - 2026 Dec TI - Content validation of the Eating Behavior and Appetite Questionnaire (EBAQ) in adolescents with obesity or overweight. PG - 100342 LID - 10.1016/j.obpill.2026.100342 [doi] LID - 100342 AB - BACKGROUND: Obesity in children and adolescents is a growing global concern. Changes in appetite and eating behaviors are clinically relevant outcomes for long-term management of obesity. The Eating Behavior and Appetite Questionnaire (EBAQ) was developed as existing patient-reported outcome measures do not comprehensively capture concepts important to individuals with obesity. Its content and psychometric validity have been demonstrated in adults; this study evaluated the content validity of the 17-item EBAQ in adolescents with obesity or overweight. METHODS: This cross-sectional qualitative study included US-based adolescents (12-17 years) with obesity or with overweight and >/=1 obesity-related complication. Cognitive interviews were conducted via telephone/teleconference using a semi-structured interview guide. Participants completed the EBAQ and provided feedback on its relevance, clarity, and comprehensiveness. Transcripts were coded using a coding framework. RESULTS: Fifteen adolescents (mean age, 14.7 years; mean body-mass index, 33.6 kg/m(2)) participated. Most (12/15, 80%) had not received obesity management medications (OMMs). All (15/15, 100%) understood the instructions and recall period, and 14/15 (93%) understood the response options. Each item was understood by >/= 80% of the participants (>/=12/15), except for Item 5 ('Appetite was controlled'). Item 5 was understood by all participants who had received OMMs (n = 3) but only a few of the treatment-naive participants (n = 4), suggesting more relevance for those on treatment. Each item was deemed relevant by >/= 54% of the participants (>/=7/15), except Item 17 ('Eating because stressed') which was considered relevant by 46% (6/13) of the participants. Overall, most participants (11/15, 73%) found the EBAQ well-structured, easy to understand and complete, and relevant. CONCLUSION: Findings support the conceptual relevance, clarity, and appropriateness of the 17-item EBAQ for adolescents with obesity or overweight. The EBAQ may be used to assess appetite and eating behavior outcomes in adolescents with obesity or overweight in clinical trials and observational studies. CI - (c) 2026 The Authors. FAU - Kanu, Chisom AU - Kanu C AD - Eli Lilly and Company, Indianapolis, IN, USA. FAU - Clucas, Claudine AU - Clucas C AD - Patient-Centered Research, Evidera, PPD Clinical Research Business of Thermo Fisher Scientific, London, UK. FAU - Gibble, Theresa Hunter AU - Gibble TH AD - Eli Lilly and Company, Indianapolis, IN, USA. FAU - Samuelson, Ashley AU - Samuelson A AD - Patient-Centered Research, Evidera, PPD Clinical Research Business of Thermo Fisher Scientific, Wilmington, NC, USA. FAU - Karn, Hayley AU - Karn H AD - Patient-Centered Research, Evidera, PPD Clinical Research Business of Thermo Fisher Scientific, London, UK. LA - eng PT - Journal Article DEP - 20261007 PL - United States TA - Obes Pillars JT - Obesity pillars JID - 9918697364706676 PMC - PMC13678099 OTO - NOTNLM OT - Adolescents OT - Appetite OT - Content validation OT - Eating behavior OT - Obesity OT - Patient-reported outcomes COIS- CK and THG are employees and shareholders of Eli Lilly and Company, which funded this study. CC, AS, and HK are current employees of Evidera, which was paid by Eli Lilly and Company to conduct this study. The Eating Behavior and Appetite Questionnaire (EBAQ) is copyrighted by Eli Lilly and Company and is free for use once permission is obtained. For permission to reproduce or use the EBAQ, contact copyright@lilly.com. EDAT- 2026/10/20 11:33 MHDA- 2026/10/20 11:34 PMCR- 2026/10/07 CRDT- 2026/10/20 08:46 PHST- 2026/07/23 00:00 [received] PHST- 2026/10/06 00:00 [revised] PHST- 2026/10/06 00:00 [accepted] PHST- 2026/10/20 11:34 [medline] PHST- 2026/10/20 11:33 [pubmed] PHST- 2026/10/20 08:46 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - S2667-3681(26)00098-7 [pii] AID - 100342 [pii] AID - 10.1016/j.obpill.2026.100342 [doi] PST - epublish SO - Obes Pillars. 2026 Oct 7;20:100342. doi: 10.1016/j.obpill.2026.100342. eCollection 2026 Dec. PMID- 42897955 OWN - NLM STAT- Publisher LR - 20261020 IS - 1879-3479 (Electronic) IS - 0020-7292 (Linking) DP - 2026 Oct 19 TI - Association between atherogenic index of plasma at 11-20 weeks of gestation and gestational diabetes risk: A prospective cohort study in China. LID - 10.1002/ijgo.71417 [doi] AB - BACKGROUND: Recent studies have linked insulin resistance and the onset of type 2 diabetes mellitus to the atherogenic index of plasma (AIP). This integrated lipid marker reflects cardiovascular risk and atherogenic dyslipidemia. However, its relationship with gestational diabetes mellitus (GDM) is not completely understood. This study aimed to evaluate the association between AIP measured at 11-20 weeks of gestation and the subsequent risk of GDM and to identify the optimal AIP threshold for GDM prediction. METHODS: A total of 2068 women with singleton pregnancies were included in this prospective cohort study from the Tongji Maternal and Child Health Cohort. AIP was calculated from fasting triglycerides and high-density lipoprotein cholesterol (HDL-C) measurements obtained at 11-20 weeks of gestation, before GDM diagnosis by 75-g oral glucose tolerance test at 24-28 weeks of gestation. Subgroup analysis, restricted cubic spline models, and multivariable logistic regression were used to assess the relationship between GDM and AIP. The predictive performance of AIP alone and in combination with maternal age, pre-pregnancy body mass index (BMI), and low-density lipoprotein cholesterol (LDL-C) was compared via receiver operating characteristic curve analysis. RESULTS: Gestational diabetes mellitus was diagnosed in 252 participants (12.3%). Women in the highest AIP quartile demonstrated a substantially higher risk than those in the lowest quartile (adjusted odds ratio 2.56; 95% confidence interval (CI) 1.63-4.01; P < 0.001), and higher AIP levels were associated with a progressively higher risk of GDM. AIP and GDM risk were found to be significantly positively correlated (P for overall association <0.001), with no statistically significant evidence of nonlinearity (P for nonlinearity = 0.700), as assessed by restricted cubic spline analysis. Based on the maximum Youden index, an AIP value equal to 0.091 was determined to be the ideal cut-off for GDM prediction. A multivariable model incorporating AIP, pre-pregnancy BMI, maternal age, and LDL-C showed improved discriminative ability compared with AIP alone (area under the curve 0.69; 95% CI 0.66-0.73). CONCLUSION: Elevated AIP levels at 11-20 weeks of gestation were independently associated with an increased risk of GDM. Importantly, the inclusion of AIP alongside established maternal risk factors enhanced predictive accuracy. The findings of this study indicate that AIP might serve as a useful adjunctive biomarker in early antenatal screening to identify women at heightened risk for GDM. CI - (c) 2026 International Federation of Gynecology and Obstetrics. FAU - Kong, Man AU - Kong M AUID- ORCID: 0000-0002-9960-1556 AD - Department of Medical Laboratory, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Zhong, Chunrong AU - Zhong C AD - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Gao, Qin AU - Gao Q AD - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Li, Qian AU - Li Q AD - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Xiong, Guoping AU - Xiong G AD - Department of Obstetrics, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Hao, Liping AU - Hao L AD - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Yang, Xuefeng AU - Yang X AD - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Lu, Zhongxin AU - Lu Z AD - Department of Medical Laboratory, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. FAU - Yang, Nianhong AU - Yang N AUID- ORCID: 0000-0003-1671-8028 AD - Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. LA - eng GR - 2013FY114200/National Program on Basic Research Project of China/ PT - Journal Article DEP - 20261019 PL - United States TA - Int J Gynaecol Obstet JT - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JID - 0210174 SB - IM OTO - NOTNLM OT - atherogenic index of plasma OT - early pregnancy OT - gestational diabetes mellitus OT - lipid metabolism OT - prospective cohort EDAT- 2026/10/20 05:30 MHDA- 2026/10/20 05:30 CRDT- 2026/10/20 03:04 PHST- 2026/09/02 00:00 [revised] PHST- 2026/04/22 00:00 [received] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/10/20 05:30 [medline] PHST- 2026/10/20 05:30 [pubmed] PHST- 2026/10/20 03:04 [entrez] AID - 10.1002/ijgo.71417 [doi] PST - aheadofprint SO - Int J Gynaecol Obstet. 2026 Oct 19. doi: 10.1002/ijgo.71417. PMID- 42897535 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261022 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jul 23 TI - Serum biomarkers and their association with disease severity and perinatal outcomes in preeclampsia: a retrospective study. LID - 10.1186/s12884-026-09691-0 [doi] LID - 1187 AB - BACKGROUND: To investigate the associations of pre-delivery serum blood urea nitrogen (BUN), uric acid (UA), cystatin C (CysC), and serum calcium levels with the occurrence of preeclampsia (PE), disease severity, and birth weight, and to evaluate their discriminatory performance in distinguishing severe preeclampsia (sPE) from PE. METHODS: A total of 328 women with singleton pregnancies who delivered at our hospital between January 2020 and December 2022 and met the inclusion and exclusion criteria were retrospectively enrolled, including 113 women in the normal pregnancy group, 125 in the PE group, and 90 in the sPE group. Maternal demographic characteristics, gestational age at blood sampling, gestational age at delivery, birth weight and related perinatal outcomes, blood pressure measurements, and laboratory parameters were collected. Multivariable binary logistic regression analyses were performed to evaluate the associations between the major laboratory biomarkers and the occurrence of PE and sPE after adjustment for maternal age, body mass index (BMI), nulliparity, assisted reproductive technology (ART) conception, and gestational age at blood sampling. Spearman correlation analysis and multiple linear regression analysis were used to assess the associations between the major laboratory biomarkers and birth weight after further adjustment for gestational age at delivery. Receiver operating characteristic (ROC) curve analysis was performed to evaluate the discriminatory performance of the major laboratory biomarkers and the combined model consisting of BUN, UA, and CysC in distinguishing sPE from PE. The calibration and clinical utility of the combined model were further evaluated using the Hosmer-Lemeshow goodness-of-fit test, calibration plots, and decision curve analysis (DCA). RESULTS: Significant differences in BUN, UA, CysC, and serum calcium levels were observed among the three groups. After adjustment for maternal age, BMI, nulliparity, ART conception, and gestational age at blood sampling, elevated BUN, UA, and CysC levels were independently associated with the occurrence of PE, with odds ratios (ORs) of 3.057, 4.432, and 6.738, respectively (all P < 0.001). Higher serum calcium levels were associated with a lower risk of PE (OR = 0.733, P = 0.019). Among women with PE, only UA remained significantly associated with sPE after adjustment for the above confounding factors (OR = 1.444, 95% confidence interval [CI]: 1.056-1.975, P = 0.021). Correlation analyses showed that BUN, UA, and CysC were negatively correlated with birth weight, whereas serum calcium was not significantly associated with birth weight. After further adjustment for gestational age at delivery, only BUN and UA remained significantly associated with reduced birth weight. ROC analysis showed that the area under the curve (AUC) values for BUN, UA, CysC, and serum calcium (evaluated in the lower-value direction) in distinguishing sPE from PE were 0.610, 0.626, 0.567, and 0.590, respectively. The combined model including BUN, UA, and CysC yielded an AUC of 0.627, with a sensitivity of 37.8%, specificity of 87.2%, positive predictive value of 68.0%, and negative predictive value of 66.1%. The Hosmer-Lemeshow goodness-of-fit test indicated no significant lack of model fit, and decision curve analysis demonstrated that the combined model provided greater net benefit than the treat-all and treat-none strategies across a threshold probability range of approximately 0.34-0.66. CONCLUSIONS: Pre-delivery levels of BUN, UA, CysC, and serum calcium were associated with the occurrence of PE, with UA being independently associated with sPE. BUN and UA remained associated with reduced birth weight after adjustment for gestational age at delivery. However, the discriminatory performance of UA, the other individual biomarkers, and the combined model for distinguishing sPE from PE was limited, and they should not be used alone to determine disease severity. Markedly elevated UA levels may help identify women with PE who require closer clinical monitoring; however, disease severity should still be comprehensively assessed based on blood pressure, proteinuria, clinical symptoms, and evidence of organ dysfunction. CI - (c) 2026. The Author(s). FAU - Feng, Chong AU - Feng C AD - Department of Obstetrics and Gynecology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. FAU - Hou, Meng AU - Hou M AD - Department of Obstetrics and Gynecology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. 1770728313@qq.com. LA - eng PT - Journal Article DEP - 20260723 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - 0 (Biomarkers) RN - 268B43MJ25 (Uric Acid) RN - SY7Q814VUP (Calcium) RN - 0 (Cystatin C) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Pre-Eclampsia/blood/diagnosis MH - Biomarkers/blood MH - Retrospective Studies MH - Adult MH - Uric Acid/blood MH - Birth Weight MH - Severity of Illness Index MH - Blood Urea Nitrogen MH - Calcium/blood MH - Cystatin C/blood MH - ROC Curve MH - Pregnancy Outcome MH - Gestational Age MH - Infant, Newborn PMC - PMC13681745 OTO - NOTNLM OT - Birth weight OT - Blood urea nitrogen OT - Cystatin C OT - Preeclampsia OT - Serum calcium OT - Uric acid COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Beijing Tongren Hospital, Capital Medical University (approval number: TREC2025-KY107). All procedures were conducted in accordance with the Declaration of Helsinki. The requirement for informed consent was handled in accordance with the approval and regulations of the ethics committee. Competing interests: The authors declare no competing interests. EDAT- 2026/10/20 05:30 MHDA- 2026/10/20 05:31 PMCR- 2026/07/23 CRDT- 2026/10/20 00:41 PHST- 2026/05/05 00:00 [received] PHST- 2026/07/17 00:00 [accepted] PHST- 2026/10/20 05:31 [medline] PHST- 2026/10/20 05:30 [pubmed] PHST- 2026/10/20 00:41 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - 10.1186/s12884-026-09691-0 [pii] AID - 9691 [pii] AID - 10.1186/s12884-026-09691-0 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jul 23;26(1):1187. doi: 10.1186/s12884-026-09691-0. PMID- 42897405 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261027 IS - 1550-7416 (Electronic) IS - 1550-7416 (Linking) VI - 28 IP - 6 DP - 2026 Oct 19 TI - Predictive Performance of pyDarwin-Selected Versus Expert-Developed Paediatric Tobramycin Population Pharmacokinetic Models for Model-Informed Precision Dosing. LID - 171 [pii] LID - 10.1208/s12248-026-01321-z [doi] AB - PyDarwin is an open-source Python package integrating machine learning with NONMEM for automated model selection; however, its utility in model-informed precision dosing (MIPD) remains unvalidated. This study aims to evaluate pyDarwin for population pharmacokinetics (PopPK) model development in MIPD compared with expert-developed models, using paediatric tobramycin as a representative case. The model-building dataset included 450 plasma concentrations from 63 children with cystic fibrosis (CF). One group manually developed a model using stepwise covariate selection, while another applied pyDarwin within a predefined 27-dimensional model space, using a fitness function that incorporated a penalty based on 24-h area under the curve (AUC(24h)). External validation was performed using 1011 concentrations from 144 children, including evaluation using all therapeutic drug monitoring (TDM) data and clinically relevant MIPD scenarios (a priori [AP], Bayesian 1, Bayesian 2). Both models included weight-based scaling, a maturation function, and estimated glomerular filtration rate as covariates on clearance, yielding comparable clearance estimates. The pyDarwin-selected model was a two-compartment model with fixed allometric scaling exponents, whereas the manual model was a one-compartment model with estimated exponents. Both models showed comparable probability of target attainment for steady-state AUC(24h). In external validation using all TDM data, the pyDarwin-selected model demonstrated better predictive performance for CF patients than manual model (prediction-based MPE -14.6% vs -41.6%; MAPE 34.0% vs 54.4%). In MIPD scenarios, the pyDarwin-selected model showed superior performance in the AP setting, with differences diminishing after Bayesian updating. These findings support pyDarwin-based automated PopPK model selection as a reliable and efficient framework for MIPD. CI - (c) 2026. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists. FAU - Wang, Jinglei AU - Wang J AUID- ORCID: 0009-0002-7803-8765 AD - Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmaceutical Sciences, Fudan University, Shanghai, 201203, China. FAU - Harwood, Kiera AU - Harwood K AUID- ORCID: 0009-0006-9507-2497 AD - Department of Paediatrics, The University of Melbourne, Melbourne, Australia. AD - Antimicrobial Group, Murdoch Children's Research Institute, Melbourne, Australia. FAU - Yang, Wenyu AU - Yang W AUID- ORCID: 0000-0002-9057-4520 AD - Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmaceutical Sciences, Fudan University, Shanghai, 201203, China. FAU - Lei, Alice AU - Lei A AUID- ORCID: 0009-0004-2404-4830 AD - Antimicrobial Group, Murdoch Children's Research Institute, Melbourne, Australia. FAU - Lai, Tony AU - Lai T AUID- ORCID: 0000-0001-9761-0072 AD - Pharmacy Department, The Children's Hospital at Westmead, Sydney, Australia. AD - School of Pharmacy, The University of Sydney, University of Sydney, Sydney, Australia. FAU - Nieforth, Keith AU - Nieforth K AUID- ORCID: 0009-0005-2170-4853 AD - Certara, Radnor, Pennsylvania, USA. FAU - Duffull, Stephen AU - Duffull S AUID- ORCID: 0000-0002-6545-9408 AD - Certara, Radnor, Pennsylvania, USA. FAU - Sale, Mark AU - Sale M AUID- ORCID: 0000-0002-6239-2359 AD - Certara, Radnor, Pennsylvania, USA. FAU - Gwee, Amanda AU - Gwee A AUID- ORCID: 0000-0003-4016-8986 AD - Department of Paediatrics, The University of Melbourne, Melbourne, Australia. AD - Antimicrobial Group, Murdoch Children's Research Institute, Melbourne, Australia. AD - Clinical Pharmacology Unit, Department of General Medicine, and Department of Infectious Diseases, the Royal Children's Hospital, Melbourne, Australia. FAU - Zhu, Xiao AU - Zhu X AUID- ORCID: 0000-0003-3295-619X AD - Department of Clinical Pharmacy and Pharmacy Administration, School of Pharmaceutical Sciences, Fudan University, Shanghai, 201203, China. xiaozhu@fudan.edu.cn. LA - eng PT - Comparative Study PT - Journal Article DEP - 20261019 PL - United States TA - AAPS J JT - The AAPS journal JID - 101223209 RN - VZ8RRZ51VK (Tobramycin) RN - 0 (Anti-Bacterial Agents) SB - IM MH - Humans MH - *Tobramycin/pharmacokinetics/administration & dosage MH - *Anti-Bacterial Agents/pharmacokinetics/administration & dosage MH - Child MH - *Models, Biological MH - Cystic Fibrosis/drug therapy/blood MH - Child, Preschool MH - Female MH - Male MH - Bayes Theorem MH - Drug Monitoring/methods MH - Area Under Curve MH - Adolescent MH - Infant MH - Precision Medicine MH - Predictive Learning Models OTO - NOTNLM OT - model-Informed Precision Dosing (MIPD) OT - paediatrics OT - population Pharmacokinetics (PopPK) OT - pyDarwin OT - tobramycin COIS- Declarations. Ethical Approval: The dataset used for tobramycin model building was obtained under ethics approval HREC 65652. The retrospective audit used for external validation was approved as a clinical audit (HREC QA/105451/RCHM-2024). Competing interests: M.S., K.N., and S.D. are employees and shareholders in Certara Inc. EDAT- 2026/10/20 05:30 MHDA- 2026/10/20 05:31 CRDT- 2026/10/20 00:17 PHST- 2026/06/17 00:00 [received] PHST- 2026/10/06 00:00 [accepted] PHST- 2026/10/20 05:31 [medline] PHST- 2026/10/20 05:30 [pubmed] PHST- 2026/10/20 00:17 [entrez] AID - 10.1208/s12248-026-01321-z [pii] AID - 10.1208/s12248-026-01321-z [doi] PST - epublish SO - AAPS J. 2026 Oct 19;28(6):171. doi: 10.1208/s12248-026-01321-z. PMID- 42896171 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261019 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Oct 19 TI - Tuberculosis Among Artisanal Miners in the Mulongo Health Zone, Democratic Republic of Congo: Unmatched Case-Control Study. PG - e93635 LID - 10.2196/93635 [doi] AB - BACKGROUND: Tuberculosis (TB) remains a major global health challenge, with 10.6 million new cases and 1.3 million deaths reported in 2022. Artisanal miners in sub‑Saharan Africa are particularly vulnerable due to poverty, overcrowded living conditions, and high HIV prevalence. In the Democratic Republic of Congo (DRC), TB prevalence among miners is high, yet determinants remain insufficiently studied. OBJECTIVE: This study aimed to identify sociodemographic, behavioral, and clinical factors associated with TB among artisanal miners in the Mulongo health zone, Haut‑Lomami Province, DRC. METHODS: We conducted an unmatched case-control study among miners aged >/=15 years. Data were collected using a validated questionnaire covering socioeconomic, behavioral, and biomedical variables. Interviewers were blinded to TB status to minimize bias. Determinants were assessed using bivariate and multivariable logistic regression. RESULTS: Poverty was strongly associated with TB (adjusted odds ratio [aOR] 3.16, 95% CI 1.95-5.11; P<.001). Primary education was associated with increased TB risk (aOR 2.78, 95% CI 1.04-7.44; P=.04), while secondary education showed a borderline association (aOR 2.53, 95% CI 0.93-6.89; P=.07). Higher education was protective (aOR 0.62, 95% CI 0.40-0.95; P=.03). Poor knowledge of TB transmission (aOR 2.11, 95% CI 1.16-3.83; P=.02), cause (aOR 1.79, 95% CI 1.00-3.20; P=.049), and diagnosis (aOR 2.49, 95% CI 1.48-4.17; P=.001) were consistently linked to higher vulnerability. HIV infection was significantly associated with TB (aOR 4.65, 95% CI 1.00-21.74; P=.049). Overcrowding was more frequent among TB cases, but in adjusted models, the association was borderline (aOR 1.65, 95% CI 0.95-2.85; P=.07). Tobacco use (aOR 1.47, 95% CI 0.83-2.61; P=.18), alcohol consumption (aOR 1.18, 95% CI 0.70-1.98; P=.54), and nutritional status (aOR 1.36, 95% CI 0.78-2.37; P=.28) were not significantly associated with TB. CONCLUSIONS: TB among artisanal miners appears to be driven primarily by poverty, limited education, poor knowledge, and HIV infection. Overcrowding showed a suggestive but nonsignificant association. Integrated interventions should prioritize poverty alleviation, improved housing, tailored health education, and strengthened TB and HIV services, while further studies are needed to clarify the role of overcrowding and other contextual factors. CI - (c)Josue Mutangala Muloye, Fiston Ilunga Mbayo, Jacques Muteba Kakoma, Francois Kitobo Mashika, Jean Claude Banze Kabwe Ilunga, Pacifique Kanku Wa Ilunga, Gloire Kasongo Lupitshi, Didy Lwamba Kabiya, Paulin Beya Wa Bitadi Mutombo. Originally published in JMIR Formative Research (https://formative.jmir.org), 19.10.2026. FAU - Mutangala Muloye, Josue AU - Mutangala Muloye J AUID- ORCID: 0009-0006-4941-1558 AD - Health Zone of Lwamba, Lwamba, Haut Lomami, The Democratic Republic of The Congo. FAU - Ilunga Mbayo, Fiston AU - Ilunga Mbayo F AUID- ORCID: 0009-0004-0354-721X AD - School of Public Health, University of Malemba Nkulu, Malemba Nkulu, Haut Lomami, The Democratic Republic of The Congo. AD - General Reference Hospital of Malemba Nkulu, Malemba Nkulu, Haut Lomami, The Democratic Republic of The Congo. FAU - Muteba Kakoma, Jacques AU - Muteba Kakoma J AUID- ORCID: 0009-0001-4910-2185 AD - University of Kamina, Kamina, Haut-Lomami, The Democratic Republic of The Congo. FAU - Kitobo Mashika, Francois AU - Kitobo Mashika F AUID- ORCID: 0009-0002-4622-0052 AD - Provincial Health Division of Haut-Lomami, Kamina, Haut Lomami, The Democratic Republic of The Congo. FAU - Banze Kabwe Ilunga, Jean Claude AU - Banze Kabwe Ilunga JC AUID- ORCID: 0009-0005-9882-4933 AD - University of Kamina, Kamina, Haut-Lomami, The Democratic Republic of The Congo. FAU - Kanku Wa Ilunga, Pacifique AU - Kanku Wa Ilunga P AUID- ORCID: 0009-0005-4738-2549 AD - University of Kamina, Kamina, Haut-Lomami, The Democratic Republic of The Congo. FAU - Kasongo Lupitshi, Gloire AU - Kasongo Lupitshi G AUID- ORCID: 0009-0005-4731-9750 AD - School of Public Health, University of Malemba Nkulu, Malemba Nkulu, Haut Lomami, The Democratic Republic of The Congo. FAU - Lwamba Kabiya, Didy AU - Lwamba Kabiya D AUID- ORCID: 0009-0002-5529-3456 AD - Higher Institute of Medical Techniques of Kamina, Kamina, Haut Lomami, The Democratic Republic of The Congo. FAU - Mutombo, Paulin Beya Wa Bitadi AU - Mutombo PBWB AUID- ORCID: 0000-0003-4663-9419 AD - School of Public Health, Medicine, University of Kinshasa, Kinshasa, Kinshasa, The Democratic Republic of The Congo. LA - eng PT - Journal Article DEP - 20261019 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Democratic Republic of the Congo/epidemiology MH - Male MH - Case-Control Studies MH - Adult MH - *Tuberculosis/epidemiology MH - *Miners/statistics & numerical data MH - Middle Aged MH - Female MH - Prevalence MH - Surveys and Questionnaires MH - Risk Factors MH - Adolescent MH - Young Adult MH - Poverty MH - HIV Infections/epidemiology OTO - NOTNLM OT - Democratic Republic of Congo OT - HIV OT - artisanal miners OT - case-control study OT - overcrowding OT - poverty OT - tuberculosis EDAT- 2026/10/19 17:31 MHDA- 2026/10/19 23:30 CRDT- 2026/10/19 16:53 PHST- 2026/02/16 00:00 [received] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/07/14 00:00 [revised] PHST- 2026/10/19 23:30 [medline] PHST- 2026/10/19 17:31 [pubmed] PHST- 2026/10/19 16:53 [entrez] AID - v10i1e93635 [pii] AID - 10.2196/93635 [doi] PST - epublish SO - JMIR Form Res. 2026 Oct 19;10:e93635. doi: 10.2196/93635. PMID- 42896087 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261022 IS - 1460-2083 (Electronic) IS - 0964-6906 (Print) IS - 0964-6906 (Linking) VI - 35 IP - 21 DP - 2026 Oct 13 TI - The monogenic forms of obesity in Saudi families. LID - 10.1093/hmg/ddag054 [doi] LID - ddag054 AB - BACKGROUND: Obesity is a multifactorial disorder with a substantial yet incompletely defined genetic component. Rare monogenic variants, particularly in consanguineous populations, may account for part of the 'missing heritability.' OBJECTIVES: To delineate the genetic contribution to severe obesity in individuals from Saudi Arabia by pinpointing known and novel monogenic variants in families presenting with extreme phenotypes. METHODS: Eight multiplex Saudi families (each comprising 9 members; range: lean body weight to severe obesity) were enrolled. Adults had a BMI of >/=30 kg/m2; children exceeded the 90th percentile (overweight) or the 97th percentile (obese). Whole-exome sequencing (WES) was performed on samples collected from two children in each family, including one child with obesity and one control child without obesity. Variant calling files were filtered for quality, frequency < 1%, and predicted functional impact. Candidate loci were prioritized using Moon (Diploid) software and manual curation, then validated by Sanger sequencing. RESULTS: Initial filtering revealed 40 rare, potentially pathogenic variants in 35 genes shared among affected relatives. Prioritization highlighted 28 variants in 19 candidate genes, encompassing established obesity-related genes (e.g. LEPR, MC4R, BDNF) and putative novel loci linked to appetite regulation, lipid metabolism, and energy balance. Segregation analysis identified both heterozygous and homozygous variants across affected individuals, reflecting variability in inheritance patterns. Seven previously reported candidate genes did not show pathogenic variants in this cohort. Carriers of prioritized variants exhibited significantly higher BMI z-scores than non-carriers (P < 0.01), underscoring a clear genotype-phenotype correlation. CONCLUSION: This study broadens the catalog of genes associated with obesity in the Saudi population and demonstrates the value of studying extreme phenotypes in consanguineous families. Both previously recognized and novel variants were identified in association with severe, early-onset obesity, reflecting genetic heterogeneity across families rather than a single underlying mechanism. These findings provide a foundation for improved genetic characterization, tailored counseling, and future functional studies. CI - (c) The Author(s) 2026. Published by Oxford University Press. FAU - Almolafikh, Sultanah Turki AU - Almolafikh ST AD - Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University,, P.O. Box 2460, Riyadh 11451, Saudi Arabia. FAU - Alshatwi, Ali A AU - Alshatwi AA AD - Department of Food Science and Nutrition, College of Food and Agricultural Sciences, King Saud University,, P.O. Box 2460, Riyadh 11451, Saudi Arabia. FAU - Orfali, Razan AU - Orfali R AUID- ORCID: 0000-0002-0584-4013 AD - Department of Pharmacology, College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 13317, Saudi Arabia. FAU - AlSaud, Haya AU - AlSaud H AD - King Faisal Specialist Hospital Research Centre, Riyadh, 13458, Saudi Arabia. AD - King Abdulaziz City for Science and Technology, Riyadh 12354, Saudi Arabia. AD - Hevolution Foundation, King Saud University, Riyadh 13519, Saudi Arabia. LA - eng GR - Research Center in King Faisal Specialist Hospital in Riyadh/ PT - Journal Article PL - England TA - Hum Mol Genet JT - Human molecular genetics JID - 9208958 RN - 0 (Receptors, Leptin) RN - 0 (Receptor, Melanocortin, Type 4) RN - 0 (LEPR protein, human) RN - 0 (MC4R protein, human) SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Pedigree MH - Female MH - *Obesity/genetics/pathology/epidemiology MH - Male MH - Child MH - *Genetic Predisposition to Disease MH - Adult MH - Receptors, Leptin/genetics MH - Exome Sequencing MH - Phenotype MH - Consanguinity MH - Receptor, Melanocortin, Type 4/genetics MH - Body Mass Index MH - Adolescent PMC - PMC13679745 OTO - NOTNLM OT - consanguineous families OT - heterozygosity OT - homozygosity OT - monogenic OT - obesity OT - rare disease OT - syndromic of obesity COIS- The authors declare no conflict of interest. EDAT- 2026/10/19 17:31 MHDA- 2026/10/19 17:32 PMCR- 2026/10/19 CRDT- 2026/10/19 15:24 PHST- 2025/10/17 00:00 [received] PHST- 2026/05/08 00:00 [revised] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/10/19 17:32 [medline] PHST- 2026/10/19 17:31 [pubmed] PHST- 2026/10/19 15:24 [entrez] PHST- 2026/10/19 00:00 [pmc-release] AID - 8943647 [pii] AID - ddag054 [pii] AID - 10.1093/hmg/ddag054 [doi] PST - ppublish SO - Hum Mol Genet. 2026 Oct 13;35(21):ddag054. doi: 10.1093/hmg/ddag054. PMID- 42895862 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261019 IS - 1743-8942 (Electronic) IS - 0167-482X (Linking) VI - 47 IP - 1 DP - 2026 Dec 31 TI - Psychological birth trauma and breastfeeding self-efficacy: a parallel mediation model of resilience and bonding. PG - 2746741 LID - 10.1080/0167482X.2026.2746741 [doi] AB - BACKGROUND: Psychological birth trauma (PBT) is associated with early breastfeeding difficulties, but pathways linking PBT to reduced breastfeeding self-efficacy (BSE) remain underexplored. OBJECTIVES: To examine statistical associations among PBT, BSE, mother-infant bonding, and psychological resilience, evaluating bonding and resilience as parallel mediators. METHODS: In this cross-sectional study, 528 postpartum women recruited from a tertiary maternity hospital completed validated scales assessing PBT, BSE, bonding, and resilience. Data were analyzed using bivariate correlations and PROCESS Macro. RESULTS: PBT was negatively correlated with BSE (r = -0.558), resilience (r = -0.559), and bonding (r = -0.459; all p < 0.001). Parallel mediation revealed significant indirect pathways via bonding (B = -0.070, 95% CI [-0.112, -0.026]) and resilience (B = -0.107, 95% CI [-0.166, -0.057]), with a total indirect effect of B = -0.177 (95% CI [-0.233, -0.121]). The direct association between PBT and BSE remained significant (B = -0.350, 95% CI [-0.435, -0.265]). CONCLUSIONS: PBT, dyadic bonding, and resilience demonstrate robust concurrent associations with initial maternal breastfeeding self-efficacy. While these cross-sectional findings delineate patterns of statistical covariance rather than temporal or causal pathways, they highlight the relevance of integrating relational and intrapersonal screening into early postpartum maternal care. FAU - Yan, Liting AU - Yan L AD - School of Medicine, Department of Obstetrics, Women and Children's Hospital, Xiamen University, Xiamen, China. FAU - Huang, Lingling AU - Huang L AD - School of Medicine, Department of Obstetrics, Women and Children's Hospital, Xiamen University, Xiamen, China. FAU - Wang, Shaofang AU - Wang S AD - School of Medicine, Nursing Department, Women and Children's Hospital, Xiamen University, Xiamen, China. FAU - Chen, Ting AU - Chen T AD - School of Medicine, Department of Obstetrics, Women and Children's Hospital, Xiamen University, Xiamen, China. FAU - Zhao, Lili AU - Zhao L AD - School of Medicine, Nursing Department, Women and Children's Hospital, Xiamen University, Xiamen, China. FAU - Huang, Yinying AU - Huang Y AD - School of Medicine, Nursing Department, Women and Children's Hospital, Xiamen University, Xiamen, China. LA - eng PT - Journal Article DEP - 20261019 PL - England TA - J Psychosom Obstet Gynaecol JT - Journal of psychosomatic obstetrics and gynaecology JID - 8308648 SB - IM MH - Humans MH - Female MH - *Self Efficacy MH - *Breast Feeding/psychology MH - *Object Attachment MH - Cross-Sectional Studies MH - Adult MH - *Resilience, Psychological MH - *Mother-Child Relations/psychology MH - Postpartum Period/psychology MH - Young Adult MH - *Mothers/psychology MH - *Parturition/psychology MH - Pregnancy OTO - NOTNLM OT - Psychological birth trauma OT - breastfeeding self-efficacy OT - mediation analysis OT - mother-infant bonding OT - psychological resilience EDAT- 2026/10/19 17:31 MHDA- 2026/10/19 17:32 CRDT- 2026/10/19 12:43 PHST- 2026/10/19 17:32 [medline] PHST- 2026/10/19 17:31 [pubmed] PHST- 2026/10/19 12:43 [entrez] AID - 10.1080/0167482X.2026.2746741 [doi] PST - ppublish SO - J Psychosom Obstet Gynaecol. 2026 Dec 31;47(1):2746741. doi: 10.1080/0167482X.2026.2746741. Epub 2026 Oct 19. PMID- 42895271 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261022 IS - 2047-2986 (Electronic) IS - 2047-2978 (Print) IS - 2047-2978 (Linking) VI - 16 DP - 2026 Oct 19 TI - External validation and application of machine learning models for obesity in Chinese children and adolescents per Chinese and WHO growth standards. PG - 04299 LID - 10.7189/jogh.16.04299 [doi] LID - 04299 AB - BACKGROUND: Childhood and adolescent obesity is a growing global public health challenge, underscoring the need for reliable tools to identify individuals at high risk. We aimed to develop, validate, and deploy machine learning (ML) models for predicting obesity in children and adolescents aged 3-18 years using multi-domain risk factors per Chinese and World Health Organization (WHO) growth standards, with an online tool for clinical and public health translation. METHODS: We conducted a population-based cross-sectional study. We used data from 22,555 participants in Beijing (2022, 2024) for training/internal validation, and data from 5,343 participants in Tangshan (2020) for external validation. We defined obesity using both Chinese and WHO growth standards. We analysed 38 features across 5 domains; we selected key predictors using least absolute shrinkage and selection operator regression. We evaluated 4 ML models using 28 performance metrics, with SHapley Additive exPlanations enhancing interpretability. RESULTS: We retained 5 features per the Chinese growth standards and 12 per the WHO growth standards. Age, maternal body mass index (BMI), paternal BMI, screen time, and birthweight were consistent predictors. The neural network achieved optimal performance per Chinese growth standards (area under the receiver operating characteristic curve (AUROC) = 0.735), and eXtreme gradient boosting performed best per WHO growth standards (AUROC = 0.736), with the corresponding external validation AUROCs of 0.699 and 0.707. We subsequently deployed user-friendly online prediction tools for translation. CONCLUSIONS: We identified two interpretable ML models for obesity in children and adolescents per both Chinese and WHO growth standards, each demonstrating modest but reliable predictive performance. CI - (c) 2026 The Authors. FAU - Zheng, Fangjieyi AU - Zheng F AD - Center for Evidence-based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Wang, Xiaoqian AU - Wang X AD - Center for Evidence-based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. AD - Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Xue, Mei AU - Xue M AD - Graduate School, Beijing University of Chinese Medicine, Beijing, China. AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. FAU - Wang, Qiong AU - Wang Q AD - Graduate School, Beijing University of Chinese Medicine, Beijing, China. AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. FAU - Zhang, Wenqian AU - Zhang W AD - Center for Evidence-based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Zhang, Zhixin AU - Zhang Z AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. AD - Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China. FAU - Niu, Wenquan AU - Niu W AD - Center for Evidence-based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20261019 PL - Scotland TA - J Glob Health JT - Journal of global health JID - 101578780 RN - Chinese people SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - Body Mass Index MH - China/epidemiology MH - Cross-Sectional Studies MH - *Machine Learning MH - *Pediatric Obesity/epidemiology MH - Predictive Learning Models MH - Risk Factors MH - World Health Organization MH - East Asian People PMC - PMC13679347 OTO - NOTNLM OT - Chinese and WHO growth standards OT - children and adolescents OT - external validation OT - machine learning OT - obesity COIS- Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests. EDAT- 2026/10/19 11:36 MHDA- 2026/10/19 11:37 PMCR- 2026/10/19 CRDT- 2026/10/19 08:35 PHST- 2026/10/19 11:37 [medline] PHST- 2026/10/19 11:36 [pubmed] PHST- 2026/10/19 08:35 [entrez] PHST- 2026/10/19 00:00 [pmc-release] AID - jogh-16-04299 [pii] AID - 10.7189/jogh.16.04299 [doi] PST - epublish SO - J Glob Health. 2026 Oct 19;16:04299. doi: 10.7189/jogh.16.04299. PMID- 42895101 OWN - NLM STAT- Publisher LR - 20261019 IS - 1619-3997 (Electronic) IS - 0300-5577 (Linking) DP - 2026 Oct 20 TI - Biochemical and anthropometric assessment of nutritional status at discharge in very-low-birth-weight infants: a retrospective cohort study. LID - 10.1515/jpm-2026-0439 [doi] AB - OBJECTIVES: To evaluate nutritional status at discharge in VLBW infants using biochemical and composite nutritional indices, and to examine their relationship with extrauterine growth restriction (EUGR; also termed "growth faltering" in more recent literature). METHODS: This retrospective cohort study included 124 very low birth weight infants (1). RESULTS: EUGR occurred in 43.5 % (cross-sectional) and 38.7 % (longitudinal) of infants. Hypouremia (18.0 %) and hypocreatininemia (12.0 %) were the most frequent abnormalities. Composite outcomes were associated with lower gestational age and small-for-gestational-age status. Cross-sectional EUGR was nominally associated with CNDO (aOR 3.72, p=0.023) and CMPDO (aOR 3.96, p=0.031) but not CPDO; given testing across four correlated composite outcomes without formal correction for multiple comparisons, these associations should be regarded as nominal. AUCs for the four composites ranged narrowly from 0.761 to 0.794 and were not formally compared. Anthropometric differences were not significant. CONCLUSIONS: Subclinical biochemical deficiency was common at discharge despite non-significant anthropometric differences. Composite biochemical indices showed similar, moderate discriminative performance across definitions; findings are hypothesis-generating and require external, prospective validation before any composite can be considered superior or used clinically. CI - (c) 2026 the author(s), published by De Gruyter, Berlin/Boston. FAU - Yaprak, Deniz AU - Yaprak D AUID- ORCID: 0000-0002-8130-7877 AD - Department of Pediatrics, Division of Neonatology, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkiye. FAU - Saygili Karagol, Belma AU - Saygili Karagol B AUID- ORCID: 0000-0003-3728-9613 AD - Department of Pediatrics, Division of Neonatology, University of Health Sciences, Gulhane Training and Research Hospital, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20261020 PL - Germany TA - J Perinat Med JT - Journal of perinatal medicine JID - 0361031 SB - IM OTO - NOTNLM OT - biochemical markers OT - composite outcomes OT - extrauterine growth restriction OT - malnutrition OT - neonatal nutrition OT - very low birth weight EDAT- 2026/10/19 11:36 MHDA- 2026/10/19 11:36 CRDT- 2026/10/19 06:04 PHST- 2026/07/25 00:00 [received] PHST- 2026/10/02 00:00 [accepted] PHST- 2026/10/19 11:36 [medline] PHST- 2026/10/19 11:36 [pubmed] PHST- 2026/10/19 06:04 [entrez] AID - jpm-2026-0439 [pii] AID - 10.1515/jpm-2026-0439 [doi] PST - aheadofprint SO - J Perinat Med. 2026 Oct 20. doi: 10.1515/jpm-2026-0439. PMID- 42894603 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261019 LR - 20261020 IS - 0019-5413 (Print) IS - 1998-3727 (Electronic) IS - 0019-5413 (Linking) VI - 60 IP - 11 DP - 2026 Nov TI - Objective Return-to-Sport (RTS) Decision Frameworks for Adolescent Shoulder and Elbow Injuries: Tests, Thresholds and Exercise Targets. PG - 3091-3106 LID - 10.1007/s43465-026-01927-7 [doi] AB - BACKGROUND: Adolescent shoulder and elbow injuries are increasing due to sports specialization and year-round training, yet return-to-sport decisions typically rely on adult-derived heuristics that fail to address the unique physiology, growth plate vulnerability, and recovery needs of developing athletes aged 10-19 years. OBJECTIVE: This review proposes a novel, objective three-pillar RTS framework integrating: (1) foundational tissue capacity, (2) dynamic movement quality and neuromuscular control, and (3) sport-specific load tolerance. We synthesize current evidence to establish provisional, consensus-based adolescent thresholds and provide a practical bedside toolkit for immediate clinical implementation. METHODS: We conducted a narrative synthesis of contemporary original evidence, consensus recommendations, and validation studies relevant to adolescent shoulder and elbow rehabilitation. Evidence was critically appraised for youth-specific validation, with explicit distinction between evidence-based interventions and emerging aspirational technologies requiring prospective adolescent cohort validation. RESULTS: We propose a hybrid benchmarking model combining limb symmetry indices (LSI >/=90%) with population-referenced percentiles (>/=25th percentile for age/sex/sport) as provisional, consensus-based thresholds. A three-stage progression is outlined: Clinic-ready (pain-free ROM, isometric IR/ER LSI >/=90%), Training-ready (dynamic rotational LSI >/=90%, preserved scapular kinematics), and Game-ready (sport-specific tolerance with 5% velocity loss during simulated exposure). We provide a low-resource bedside toolkit including belt-stabilized hand-held dynamometry, Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST), Push-Up Plus, Athletic Shoulder positions, seated medicine-ball throw, and simple interval tolerance simulations with specific protocols and thresholds. A stepwise algorithm advances from capacity --> movement quality --> load tolerance with targeted remediation at each gate. CONCLUSION: Moving beyond time-based or adult-derived heuristics, this objective multidimensional framework aligns tissue recovery with sport-specific demands through quantifiable metrics. While provisional thresholds require further adolescent validation, the framework offers an evidence-guided pathway that mitigates reinjury risk, restores performance, and supports safe reintegration into sport. Implementation requires adolescent-specific normative databases, stakeholder communication, and cost-effective technological integration for equitable adoption. CI - (c) Indian Orthopaedics Association 2026. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. FAU - Li, JiaYu AU - Li J AD - Wushu Department, Wushu College of Henan University, Henan University, Kaifeng, 475000 Henan China. ROR: https://ror.org/003xyzq10. GRID: grid.256922.8. ISNI: 0000 0000 9139 560X FAU - Geng, ShengKai AU - Geng S AD - Wushu Department, Wushu College of Henan University, Henan University, Kaifeng, 475000 Henan China. ROR: https://ror.org/003xyzq10. GRID: grid.256922.8. ISNI: 0000 0000 9139 560X LA - eng PT - Journal Article PT - Review DEP - 20260813 PL - Switzerland TA - Indian J Orthop JT - Indian journal of orthopaedics JID - 0137736 PMC - PMC13676577 OTO - NOTNLM OT - Adolescent athletes OT - Objective assessment OT - Rehabilitation framework OT - Return-to-sport criteria OT - Shoulder and elbow injuries COIS- Conflict of InterestThe authors declare no financial or other relationships with commercial entities that could be perceived to influence the content of this manuscript. No author has received honoraria, consulting fees, in-kind equipment, or research support from device manufacturers discussed in this review. All technology references in the manuscript are illustrative and device-agnostic; when specific systems are mentioned they are examples only and not endorsements. EDAT- 2026/10/19 05:30 MHDA- 2026/10/19 05:31 PMCR- 2027/08/13 CRDT- 2026/10/19 04:00 PHST- 2025/12/13 00:00 [received] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/10/19 05:31 [medline] PHST- 2026/10/19 05:30 [pubmed] PHST- 2026/10/19 04:00 [entrez] PHST- 2027/08/13 00:00 [pmc-release] AID - 1927 [pii] AID - 10.1007/s43465-026-01927-7 [doi] PST - epublish SO - Indian J Orthop. 2026 Aug 13;60(11):3091-3106. doi: 10.1007/s43465-026-01927-7. eCollection 2026 Nov. PMID- 42893551 OWN - NLM STAT- Publisher LR - 20261018 IS - 1475-357X (Print) IS - 1475-357X (Linking) DP - 2026 Oct 18 TI - Longitudinal associations between dietary intake and common mental disorders among adolescents in Australia. LID - 10.1111/camh.70129 [doi] AB - BACKGROUND: There is a need for more longitudinal research exploring temporal associations between diet quality and common mental disorders (CMDs) during adolescence. This study examined prospective associations between indicators of adolescents' diet quality (fruit, vegetable, sugar-sweetened beverage [SSB] intakes) and risk of depression and anxiety onset over 3 years. We hypothesised that higher fruit and vegetable intake, and lower SSB intake, would be associated with lower risk of CMDs. METHODS: 6537 Australian adolescents (mean age 12.65 years at baseline) completed surveys at baseline, 1-, 2- and 3-year follow-ups. We fitted Generalised Estimating Equations Poisson regression models to assess longitudinal associations between daily servings of fruit, vegetables and SSBs, and risk of depression and anxiety onset (binary cut-points on validated scales) over 3 years. Models were re-run for males and females. Analyses excluded participants who met thresholds for depression or anxiety at baseline to increase confidence that diet predicted CMD onset. RESULTS: Higher fruit intake was associated with lower risk of depression (adjusted RR: 0.87, 95% CI: 0.82-0.93) and anxiety (adjusted RR: 0.93, 95% CI: 0.87-0.99) over 3 years, with limited evidence of sex differences. Higher SSB intake (log-transformed) was associated with higher CMD risk for both sexes, but more strongly for males (depression: adjusted RR: 3.25, 95% CI: 2.02-5.23; anxiety: adjusted RR: 5.50, 95% CI: 3.39-8.90) than females (depression: adjusted RR: 3.10, 95% CI: 2.06-4.68; anxiety: adjusted RR: 2.04, 95% CI: 1.23-3.37). Results inform the Global burden of disease Lifestyle And mental Disorders project (DERR2-https://doi.org/10.2196/65576). CONCLUSIONS: Longitudinal research exposing temporal associations between diet and CMDs may inform prevention/intervention efforts targeting modifiable risk factors for CMDs. CI - (c) 2026 The Author(s). Child and Adolescent Mental Health published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. FAU - Davidson, Lily AU - Davidson L AUID- ORCID: 0000-0002-2811-0856 AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. FAU - Ashtree, Deborah N AU - Ashtree DN AUID- ORCID: 0000-0003-3680-3860 AD - Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, Geelong, Vic., Australia. FAU - Osman, Bridie AU - Osman B AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. FAU - Smout, Scarlett AU - Smout S AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. FAU - Newton, Nicola C AU - Newton NC AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. FAU - Gardner, Lauren A AU - Gardner LA AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. FAU - O'Neil, Adrienne AU - O'Neil A AD - Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, Geelong, Vic., Australia. FAU - Jacka, Felice AU - Jacka F AD - Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, Geelong, Vic., Australia. AD - Centre for Adolescent Health, Murdoch Children's Research Institute, Melbourne, Vic., Australia. AD - College of Public Health, Medical & Veterinary Sciences, James Cook University, Townsville, Qld, Australia. FAU - Orr, Rebecca AU - Orr R AUID- ORCID: 0000-0002-2422-5533 AD - Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, Geelong, Vic., Australia. FAU - Lane, Melissa AU - Lane M AD - Deakin University, IMPACT - The Institute for Mental and Physical Health and Clinical Translation, Food & Mood Centre, Geelong, Vic., Australia. FAU - Teesson, Maree AU - Teesson M AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. FAU - Champion, Katrina E AU - Champion KE AD - The Matilda Centre for Research in Mental Health and Substance Use, The University of Sydney, Sydney, NSW, Australia. AD - School of Public Health, The University of Sydney, Sydney, NSW, Australia. LA - eng GR - APP11349009/Centre of Research Excellence in Prevention and Early Intervention of Mental Illness and Substance Use/ GR - APP1078407/Australian National Health and Medical Research Council/ GR - APP1120641/Australian National Health and Medical Research Council/ GR - APP1166377/Australian National Health and Medical Research Council/ GR - Paul Ramsay Foundation/ PT - Journal Article DEP - 20261018 PL - England TA - Child Adolesc Ment Health JT - Child and adolescent mental health JID - 101142157 SB - IM OTO - NOTNLM OT - Adolescent OT - anxiety OT - depression OT - diet OT - mental disorder OT - prospective studies EDAT- 2026/10/18 17:32 MHDA- 2026/10/18 17:32 CRDT- 2026/10/18 15:03 PHST- 2026/09/03 00:00 [accepted] PHST- 2026/10/18 17:32 [medline] PHST- 2026/10/18 17:32 [pubmed] PHST- 2026/10/18 15:03 [entrez] AID - 10.1111/camh.70129 [doi] PST - aheadofprint SO - Child Adolesc Ment Health. 2026 Oct 18. doi: 10.1111/camh.70129. PMID- 42893521 OWN - NLM STAT- MEDLINE DCOM- 20261018 LR - 20261020 IS - 1460-6984 (Electronic) IS - 1368-2822 (Print) IS - 1368-2822 (Linking) VI - 61 IP - 6 DP - 2026 Nov-Dec TI - Cultural and Linguistic Adaptation of Diagnostic Language Assessments: A Scoping Review. PG - e70357 LID - 10.1111/1460-6984.70357 [doi] LID - e70357 AB - BACKGROUND: Diagnostic language assessments are central to identifying developmental language disorder; however, many widely used tools were developed and normed within monolingual Western contexts. Their application in multilingual and multicultural settings raises concerns about linguistic, cultural and psychometric validity. Although adaptation of diagnostic tools is frequently reported, the scope and quality of published adaptation research has not been systematically mapped. AIMS: This scoping review aimed to map the literature on the cultural and linguistic adaptation of diagnostic language assessment tools for multilingual and multicultural child populations, to describe the adaptation and validation approaches used, and to identify gaps relevant to future diagnostic tool development. METHODS AND PROCEDURES: A scoping review was conducted following the Arksey and O'Malley framework and reported in line with PRISMA-ScR guidelines. Searches were conducted across four electronic databases for peer-reviewed studies published between 2014 and 2025. Studies (n = 14) were included if they reported the translation, cultural adaptation, or contextual modification of diagnostic language assessments for children aged 3-12 years. Data were charted on study characteristics, assessment tools, adaptation frameworks, validation methods and reported challenges. OUTCOMES AND RESULTS: Fourteen studies met inclusion criteria, representing 10 countries. Adapted tools assessed a range of language domains. Most studies reported multi-step adaptation processes and referenced established international frameworks; however, the depth of cultural adaptation and the rigour of psychometric validation varied substantially. CONCLUSIONS AND IMPLICATIONS: Diagnostic language assessment adaptation research remains fragmented and methodologically inconsistent. The limited evidence base across diverse multilingual settings highlights an urgent need for contextually grounded, psychometrically robust diagnostic tools to support equitable assessment in multilingual settings. WHAT THIS PAPER ADDS: What is already known on this subject Diagnostic language assessments are often developed in monolingual Western contexts and may not be valid for multilingual children. Translation and cultural adaptation of assessments are increasingly reported, but practices vary widely. What this paper adds to existing knowledge This review provides a systematic mapping of diagnostic language assessment adaptations, highlighting substantial variation in adaptation depth and validation quality. Only 14 studies across 10 countries were identified, indicating that the evidence base for culturally and linguistically adapted diagnostic language assessments remains limited and geographically fragmented. What are the potential or actual clinical implications of this work? Clinicians should exercise caution when using translated diagnostic tools and adopt multi-method, culturally responsive assessment practices. The findings provide a framework to guide future diagnostic tool adaptation and development in multilingual contexts. CI - (c) 2026 The Author(s). International Journal of Language & Communication Disorders published by John Wiley & Sons Ltd on behalf of Royal College of Speech and Language Therapists. FAU - Botes, Mignon AU - Botes M AUID- ORCID: 0000-0003-3796-6901 AD - Department of Speech-Language Pathology, University of the Witwatersrand, Johannesburg, South Africa. FAU - Masuku, Khetsiwe AU - Masuku K AUID- ORCID: 0000-0003-3413-689X AD - Department of Speech-Language Pathology, University of the Witwatersrand, Johannesburg, South Africa. FAU - Mupawose, Anniah AU - Mupawose A AUID- ORCID: 0000-0001-5009-0452 AD - Department of Speech-Language Pathology, University of the Witwatersrand, Johannesburg, South Africa. LA - eng PT - Journal Article PT - Review PT - Scoping Review PL - United States TA - Int J Lang Commun Disord JT - International journal of language & communication disorders JID - 9803709 SB - IM MH - Humans MH - Child MH - *Language Development Disorders/diagnosis MH - Multilingualism MH - Psychometrics MH - *Language Tests/standards MH - Child, Preschool MH - Linguistics MH - Reproducibility of Results PMC - PMC13677082 OTO - NOTNLM OT - cultural adaptation OT - diagnostic language assessment OT - linguistic adaptation OT - multilingual children OT - scoping review COIS- The authors declare no conflicts of interest. EDAT- 2026/10/18 17:32 MHDA- 2026/10/18 17:33 PMCR- 2026/10/18 CRDT- 2026/10/18 12:53 PHST- 2026/10/06 00:00 [revised] PHST- 2026/01/16 00:00 [received] PHST- 2026/10/08 00:00 [accepted] PHST- 2026/10/18 17:33 [medline] PHST- 2026/10/18 17:32 [pubmed] PHST- 2026/10/18 12:53 [entrez] PHST- 2026/10/18 00:00 [pmc-release] AID - JLCD70357 [pii] AID - 10.1111/1460-6984.70357 [doi] PST - ppublish SO - Int J Lang Commun Disord. 2026 Nov-Dec;61(6):e70357. doi: 10.1111/1460-6984.70357. PMID- 42893396 OWN - NLM STAT- Publisher LR - 20261018 IS - 1751-8431 (Electronic) IS - 1751-8423 (Linking) DP - 2026 Oct 18 TI - Classroom-based observation and intervention of executive function for special education teachers working with preschoolers with Autism. PG - 1-17 LID - 10.1080/17518423.2026.2750397 [doi] AB - BACKGROUND/OBJECTIVES: Executive function (EF) related behavioral challenges are frequently observed in preschool children with autism spectrum disorder. However, structured, classroom-based observation of these behaviors by teachers remains difficult, resulting in limited practical assessment and recommendations for classroom-based support. This study aimed to examine the feasibility of teacher-administered EF assessment in special education centers and to formulate preliminary, expert-informed recommendations for autistic children with varying communication abilities. METHODS: A mixed-methods sequential design was used. A total of 793 children with autism aged 3-6 years were assessed by trained teachers. Multidisciplinary expert consultation was conducted to formulate preliminary recommendations for classroom activities based on age and communication profiles. RESULTS: Teachers achieved at least 85% accuracy in score conversion and interpretation, supporting the feasibility of its use in a special education classroom. Patterns of EF-related behavioral challenges observed in 793 children aged 3-6 years were integrated with existing evidence and multidisciplinary expert consensus to inform preliminary recommendations for classroom activities. Working memory, inhibitory control, and cognitive flexibility were most evident, especially in children with limited verbal communication and those requiring intensive classroom support. Expert-informed classroom activities, including structured play, rule-changing games, memory-based exercises, emotional reflection tasks, and narrative planning, were subsequently suggested with increasing complexity across age groups and levels of communication ability. CONCLUSIONS: The findings provide preliminary support for the teacher-administered MU.EF-102 of the classroom use and informed age- and communication-responsive, expert-informed classroom activity recommendations. The effectiveness of these recommendations requires evaluation in future intervention studies. FAU - Aonsri, Chanada AU - Aonsri C AD - Centre of Integrative Physical Therapy and Human Movement Sciences (CIPTHM), School of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand. FAU - Siritaratiwat, Wantana AU - Siritaratiwat W AD - Centre of Integrative Physical Therapy and Human Movement Sciences (CIPTHM), School of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand. FAU - Mongput, Korrawan AU - Mongput K AD - School of Psychology and Human Development, Faculty of Education, Khon Kaen University, Khon Kaen, Thailand. FAU - Mato, Lugkana AU - Mato L AD - Centre of Integrative Physical Therapy and Human Movement Sciences (CIPTHM), School of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand. FAU - Chatprem, Thiwaphon AU - Chatprem T AD - Centre of Integrative Physical Therapy and Human Movement Sciences (CIPTHM), School of Physical Therapy, Faculty of Associated Medical Sciences, Khon Kaen University, Khon Kaen, Thailand. FAU - Vincent, Claude AU - Vincent C AD - Faculty of Medicine, School of Rehabilitation Sciences, Universite Laval, Quebec, QC, Canada. LA - eng PT - Journal Article DEP - 20261018 PL - England TA - Dev Neurorehabil JT - Developmental neurorehabilitation JID - 101304394 SB - IM OTO - NOTNLM OT - Autism spectrum disorder OT - executive function OT - preschool children OT - special education OT - teacher-administered assessment EDAT- 2026/10/18 11:29 MHDA- 2026/10/18 11:29 CRDT- 2026/10/18 07:33 PHST- 2026/10/18 11:29 [medline] PHST- 2026/10/18 11:29 [pubmed] PHST- 2026/10/18 07:33 [entrez] AID - 10.1080/17518423.2026.2750397 [doi] PST - aheadofprint SO - Dev Neurorehabil. 2026 Oct 18:1-17. doi: 10.1080/17518423.2026.2750397. PMID- 42893364 OWN - NLM STAT- Publisher LR - 20261018 IS - 2391-5854 (Electronic) IS - 0033-2674 (Linking) DP - 2026 May 30 TI - PANDAS in the post-COVID era: links to group A Streptococcus and implications for pediatric neuropsychiatry ‒ a narrative review. PG - 1-13 LID - 218782 [pii] LID - 10.12740/PP/OnlineFirst/218782 [doi] AB - Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS) are defined by the abrupt onset of tics and/or obsessive-compulsive symptoms temporally linked to group A Streptococcus (GAS). Post-pandemic reports note a rebound of pediatric invasive GAS (iGAS), providing an epidemiologic backdrop for more frequent neuropsychiatric presentations. This narrative review (2020-2025; PubMed/MEDLINE, ScienceDirect, Wiley Online Library, MDPI, plus snowballing) synthesizes evidence on the PANDAS/PANS-GAS relationship, clinical spectrum, differential diagnosis with Sydenham chorea (SC), immunopathogenesis, and treatment. Beyond classic OCD and motor tics, the phenotype includes speech disfluency, ocular tics, and acute eating restriction with functional and nutritional risk. Immunologic data support molecular mimicry, Th17/IL-17-driven neuroinflammation, blood‒brain barrier dysfunction, and antineuronal or folate receptor-alpha antibodies; however, no single validated biomarker exists, and antistreptolysin O (ASO), anti-DNase B document exposure only. Management is individualized and multimodal: antibiotic eradication (with prophylaxis in selected, frequently relapsing cases), immunomodulation (steroids, intravenous immunoglobulin (IVIG), therapeutic plasma exchange) for severe/refractory courses, and Cognitive Behavioral Therapy/Selective Serotonin Reuptake Inhibitors (CBT/SSRIs) for core psychiatric symptoms. Contemporary data strengthen a post-streptococcal, immune-mediated framework while underscoring heterogeneous case definitions and the paucity of high-quality trials; prospective biomarker and treatment validation remain priorities. FAU - Kozlak, Julia AU - Kozlak J AD - Student Scientific Circle at the Department of Infectious and Tropical Diseases, Andrzej Frycz Modrzewski Krakow University, Medical College, Krakow, Poland. FAU - Stopyra, Lidia AU - Stopyra L AD - Department of Infectious and Tropical Diseases, Medical College, Andrzej Frycz Modrzewski Krakow University. FAU - Gisel, Marcel AU - Gisel M AD - Student Scientific Circle at the Department of Infectious and Tropical Diseases, Andrzej Frycz Modrzewski Krakow University, Medical College, Krakow, Poland. LA - eng PT - Journal Article PT - Review TT - PANDAS w czasie post COVID-19: zwiazek z zakazeniem paciorkowcami grupy A i implikacje dla neuropsychiatrii dzieciecej - przeglad narracyjny. DEP - 20260530 PL - Poland TA - Psychiatr Pol JT - Psychiatria polska JID - 0103314 SB - IM OTO - NOTNLM OT - Sydenheim chorea OT - obsessive-compulsive disorder OT - tics EDAT- 2026/10/18 11:29 MHDA- 2026/10/18 11:29 CRDT- 2026/10/18 05:34 PHST- 2026/10/18 11:29 [medline] PHST- 2026/10/18 11:29 [pubmed] PHST- 2026/10/18 05:34 [entrez] AID - 218782 [pii] AID - 10.12740/PP/OnlineFirst/218782 [doi] PST - aheadofprint SO - Psychiatr Pol. 2026 May 30:1-13. doi: 10.12740/PP/OnlineFirst/218782. PMID- 42892472 OWN - NLM STAT- Publisher LR - 20261023 IS - 1874-1754 (Electronic) IS - 0167-5273 (Linking) VI - 466 DP - 2026 Oct 17 TI - QTc reference ranges in eastern European children aged 6 to 18 years: a large-scale population study and comparison with international normative datasets. PG - 134990 LID - S0167-5273(26)00840-5 [pii] LID - 10.1016/j.ijcard.2026.134990 [doi] AB - BACKGROUND: QT interval corrected for heart rate (QTc) is important. Appropriate reference ranges support ECG interpretation, but data for Eastern European children remain limited. We aimed to derive age- and sex-stratified QTc reference ranges, estimate proportions exceeding cut-offs, and compare results with normative datasets. METHODS: 12‑lead ECGs from 22,335 children aged 6-18 years were obtained through the CARDIOPED screening programme in northwestern Transylvania, Romania. QTc was calculated using Bazett's formula. Age- and sex-stratified percentile curves (P2.5-P97.5) were derived using spline regression. Correlations with anthropometric variables and proportions exceeding QTc cut-offs of 440, 460, and 480 ms were assessed. Results were compared with the Davignon, Rijnbeek, Saarel, Bratincsak, and Mason datasets. RESULTS: Overall median QTc was 408.2 ms in males and 409.9 ms in females. Upper reference limits (P97.5) were 451.4 ms and 457.0 ms, respectively. The sex difference increased from 2.6 ms in the 6-12-year group to 5.7 ms in the 12-18-year group. Obesity and anthropometric variables showed weak, non-significant correlations with QTc. Values were closely aligned with Rijnbeek et al. QTc exceeded 440 ms in 6.0% of males and 460 ms in 1.2% of females; 14 children (0.06%) had a single screening QTc measurement >/=480 ms. CONCLUSIONS: QTc reference ranges in this Eastern European cohort were consistent with European paediatric normative data. Upper reference limits were approximately 450 ms in males and 460 ms in females. Proportions exceeding cut-offs describe cohort distributions, not diagnostic false-positive rates. Percentiles are statistical reference limits rather than validated clinical decision or diagnostic thresholds. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Cismaru, Gabriel AU - Cismaru G AD - 4th Department of Internal Medicine, Cardiology Rehabilitation, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. Electronic address: gabi_cismaru@yahoo.com. FAU - Lazea, Cecilia AU - Lazea C AD - Department of Pediatrics I, Emergency Clinic Hospital for Children, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. FAU - Muresan, Lucian AU - Muresan L AD - Cardiology Department, "Emile Muller" Hospital, Mulhouse, 68100, France. FAU - Gusetu, Gabriel AU - Gusetu G AD - 4th Department of Internal Medicine, Cardiology Rehabilitation, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. FAU - Rosu, Radu AU - Rosu R AD - 4th Department of Internal Medicine, Cardiology Rehabilitation, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. FAU - Pop, Dana AU - Pop D AD - 4th Department of Internal Medicine, Cardiology Rehabilitation, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. FAU - Negru, Alina AU - Negru A AD - Department of Cardiology II, University of Medicine and Pharmacy "Victor Babes", Timisoara, 300041, Romania. FAU - Cainap, Simona Sorana AU - Cainap SS AD - Department of Pediatrics II, Emergency Clinic Hospital for Children, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. LA - eng PT - Journal Article DEP - 20261017 PL - Netherlands TA - Int J Cardiol JT - International journal of cardiology JID - 8200291 SB - IM OTO - NOTNLM OT - Bazett OT - Children OT - Electrocardiography OT - LQTS OT - QTc OT - Screening COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2026/10/18 05:37 MHDA- 2026/10/18 05:37 CRDT- 2026/10/18 01:48 PHST- 2026/06/29 00:00 [received] PHST- 2026/10/09 00:00 [revised] PHST- 2026/10/11 00:00 [accepted] PHST- 2026/10/18 05:37 [pubmed] PHST- 2026/10/18 05:37 [medline] PHST- 2026/10/18 01:48 [entrez] AID - S0167-5273(26)00840-5 [pii] AID - 10.1016/j.ijcard.2026.134990 [doi] PST - aheadofprint SO - Int J Cardiol. 2026 Oct 17;466:134990. doi: 10.1016/j.ijcard.2026.134990. PMID- 42891355 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Physical education and psychosocial vulnerability in adolescent suicide-related risk: a transnational cross-sectional explainable machine-learning analysis of student health survey data. PG - 1898064 LID - 10.3389/fpsyt.2026.1898064 [doi] LID - 1898064 AB - BACKGROUND: Adolescent suicide attempt is a major public health concern linked to psychosocial distress, school environment, health-risk behaviors, and physical activity patterns. This study aimed to develop an explainable XGBoost model for adolescent suicide-attempt status and to determine whether physical inactivity and low physical education (PE) participation could serve as informative school-based indicators. METHODS: Data were obtained from the Global School-based Student Health Survey conducted in Argentina in 2018, Anguilla in 2016, and Jamaica in 2017. The Argentina dataset was used for model training, while Anguilla and Jamaica were combined as an independent validation cohort. The outcome was self-reported suicide attempt during the past 12 months. Candidate predictors included demographic, anthropometric, dietary, psychosocial, violence- and injury-related, tobacco-related, sexual behavior, physical activity, and PE-related variables. An XGBoost model was developed using nested cross-validation, staged hyperparameter tuning, and Bayesian fine-tuning. Model performance was evaluated by the area under the receiver operating characteristic curve (AUC). SHAP and partial dependence plots were used for interpretation. RESULTS: A total of 27,710 adolescents were included; 5,165 (18.6%) reported at least one suicide attempt. The final model achieved an independent validation AUC of 0.7928 (95% CI: 0.7790-0.8066). The top 18 SHAP-ranked predictors retained a cumulative 10-fold cross-validated AUC of 0.7865. Loneliness was the most influential predictor, followed by sex, insomnia, early cigarette use, PE days, physical attack, school peer kindness, and physical activity. Physical inactivity and low PE participation showed nonlinear associations with predicted suicide-attempt risk. CONCLUSIONS: Loneliness and insomnia represented the psychosocial vulnerability profile, while physical inactivity and limited PE participation emerged as potentially informative school-based indicators requiring further longitudinal investigation. These findings support risk-stratified prevention strategies integrating early psychological identification with inclusive, socially supportive physical activity and PE programs. CI - Copyright (c) 2026 Liu, Guo, Ma, Shi, Ma and Li. FAU - Liu, Heyi AU - Liu H AD - Tianjin College, University of Science and Technology Beijing, Tianjin, China. FAU - Guo, Jianbin AU - Guo J AD - Quality Control Office, Kailuan Mental Health Center, Tangshan, China. FAU - Ma, Xinwei AU - Ma X AD - Department of Radiology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China. FAU - Shi, Cheng AU - Shi C AD - Department of Cardiology, Suzhou BenQ Medical Center, Suzhou, China. FAU - Ma, Xiaoming AU - Ma X AD - Department of Cardiology, Suzhou BenQ Medical Center, Suzhou, China. AD - Department of Neurology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China. AD - Department of Neurology, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing, China. AD - Suzhou Key Laboratory of Integrated Stroke Prevention, Treatment and Rehabilitation, Suzhou, China. FAU - Li, Jingwei AU - Li J AD - Department of Neurology, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China. AD - Department of Neurology, Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital, Nanjing, China. AD - Suzhou Key Laboratory of Integrated Stroke Prevention, Treatment and Rehabilitation, Suzhou, China. AD - Suzhou Research Centre of Medical School, Nanjing University, Suzhou, China. AD - Institute of Brain Sciences, Nanjing University, Nanjing, China. AD - Nanjing Neurology Clinic Medical Center, Nanjing, China. LA - eng PT - Journal Article DEP - 20261002 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13674449 OTO - NOTNLM OT - adolescent OT - machine learning OT - mental health OT - physical education and training OT - suicide COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:38 MHDA- 2026/10/17 23:39 PMCR- 2026/10/02 CRDT- 2026/10/17 21:49 PHST- 2026/06/04 00:00 [received] PHST- 2026/09/05 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/17 23:39 [medline] PHST- 2026/10/17 23:38 [pubmed] PHST- 2026/10/17 21:49 [entrez] PHST- 2026/10/02 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1898064 [doi] PST - epublish SO - Front Psychiatry. 2026 Oct 2;17:1898064. doi: 10.3389/fpsyt.2026.1898064. eCollection 2026. PMID- 42889669 OWN - NLM STAT- MEDLINE DCOM- 20261017 LR - 20261019 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - The microbiome-metabolite-vaccine axis: context-dependent modulators of immunogenicity and durability. PG - 1972642 LID - 10.3389/fimmu.2026.1972642 [doi] LID - 1972642 AB - Vaccine responses vary markedly between individuals, yet age, genetics, prior antigen exposure, comorbidity, nutrition and vaccine platform explain only part of this heterogeneity. The intestinal microbiome is a candidate modulator through microbial metabolites and parallel non-metabolic signals. Human studies link microbial features to vaccine outcomes, but taxa rarely replicate across geography, age and platform. Small randomised antibiotic studies identify effects of treatment assignment, not necessarily microbiome mediation; infant microbial rescue has been demonstrated in mice rather than infants. Amongst the pathways considered, short-chain fatty acids have the largest mechanistic evidence base, predominantly preclinical, but acetate, propionate and butyrate differ in targets, exposure and direction of effect, and direct human vaccine mediation remains unestablished. Null findings for BNT162b2 in microbiota-depleted mice and for overall antibody responses in an older-adult probiotic trial argue against universal microbiome dependence or probiotic benefit. We organise the evidence around a microbial function-mediator-exposure-immune-checkpoint-endpoint chain, retaining a primary focus on metabolites. Vaccine take, peak antibody, decay and recall are distinguished from clinical protection. We also separate microbiome-modifying probiotics from antigen-delivery platforms. A decision-gated workflow links signature discovery, source and target verification, independent validation, randomised intervention and demonstrated clinical utility. Microbiome-guided vaccination remains a research strategy rather than an established clinical practice. CI - Copyright (c) 2026 Sun, Yang, Lv, Yu and Si. FAU - Sun, Ge AU - Sun G AD - Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, China. FAU - Yang, Jingyi AU - Yang J AD - Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, China. FAU - Lv, Suzhen AU - Lv S AD - Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, China. FAU - Yu, Lijie AU - Yu L AD - Department of Obstetrics and Gynecology, Lishu County Traditional Chinese Medicine Hospital, Siping, China. FAU - Si, Lihui AU - Si L AD - Department of Obstetrics and Gynecology, The Second Hospital of Jilin University, Changchun, China. LA - eng PT - Journal Article PT - Review DEP - 20261001 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Vaccines) SB - IM MH - Humans MH - Animals MH - *Gastrointestinal Microbiome/immunology MH - *Immunogenicity, Vaccine MH - *Vaccines/immunology MH - Probiotics MH - Vaccination PMC - PMC13669876 OTO - NOTNLM OT - antibody durability OT - gut microbiome OT - immune memory OT - immunometabolism OT - microbial metabolites OT - precision vaccination OT - systems vaccinology OT - vaccine immunogenicity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:12 MHDA- 2026/10/17 23:13 PMCR- 2026/10/01 CRDT- 2026/10/17 12:00 PHST- 2026/08/19 00:00 [received] PHST- 2026/09/10 00:00 [revised] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/10/17 23:13 [medline] PHST- 2026/10/17 23:12 [pubmed] PHST- 2026/10/17 12:00 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1972642 [doi] PST - epublish SO - Front Immunol. 2026 Oct 1;17:1972642. doi: 10.3389/fimmu.2026.1972642. eCollection 2026. PMID- 42889450 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 1976-1457 (Print) IS - 2005-6168 (Electronic) IS - 1976-1457 (Linking) VI - 20 IP - 5 DP - 2026 Oct TI - Comparability of food frequency questionnaires between Korean Children's Environmental Health Study (Ko-CHENS) and Korean Genome and Epidemiology Study (KoGES) in pregnant women. PG - 866-878 LID - 10.4162/nrp.2026.20.5.866 [doi] AB - BACKGROUND/OBJECTIVES: The Korean Children's Environmental Health Study (Ko-CHENS) developed a food frequency questionnaire (FFQ) to assess maternal dietary intake during pregnancy. This FFQ shares high structural similarity with the validated FFQ of the Korean Genome and Epidemiology Study (KoGES), a representative dietary assessment tool for the Korean adult population, which includes 97 of the 112 items in the Ko-CHENS FFQ. The comparability of the Ko-CHENS and KoGES FFQs among pregnant women was evaluated. SUBJECTS/METHODS: Ninety-four women recruited from Kangwon National University Hospital between December 2024 and February 2025 were included. The participants consecutively completed the Ko-CHENS and KoGES FFQs. The nutrient intakes were adjusted for the total energy intake using the residual method. Log-transformed intakes of energy, nutrients, and food groups were compared using the correlation coefficients, cross-classification percent agreement, weighted kappa statistics, and Bland-Altman plots. RESULTS: The Ko-CHENS FFQ yielded higher absolute intake estimates for energy and the majority of nutrients and food groups than the KoGES FFQ. The Pearson or Spearman correlation coefficients ranged from 0.34 (vitamin E) to 0.68 (beta-carotene) for energy and nutrients and from 0.15 (sugars and jams) to 0.77 (salted vegetables) for food groups, with median values of 0.55 and 0.61, respectively. The median proportions of the participants classified into the same or adjacent quartiles were 96.39% for energy and nutrients and 96.52% for food groups. The weighted kappa statistics ranged from 0.23 to 0.52 for energy and nutrients and from 0.06 to 0.59 for food groups, with median values of 0.38 and 0.45, respectively. The Bland-Altman plots for energy and macronutrients showed that the data points were primarily within the limits of agreement. CONCLUSION: The Ko-CHENS and KoGES FFQs showed fair-to-moderate comparability, suggesting that the Ko-CHENS FFQ can be used for ranking Korean pregnant women based on their dietary intake levels. CI - (c)2026 The Korean Nutrition Society and the Korean Society of Community Nutrition. FAU - Cho, Minsu AU - Cho M AUID- ORCID: 0009-0007-8243-1750 AD - Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Korea. FAU - Kim, Bom AU - Kim B AUID- ORCID: 0000-0001-9405-2407 AD - Department of Medical Informatics, Kangwon National University School of Medicine, Chuncheon 24341, Korea. FAU - Kim, Hyesook AU - Kim H AUID- ORCID: 0000-0002-4840-3082 AD - Department of Food and Nutrition, Wonkwang University, Iksan 54538, Korea. FAU - Na, Sunghun AU - Na S AUID- ORCID: 0000-0002-2803-8356 AD - Department of Obstetrics and Gynecology, Kangwon National University School of Medicine, Chuncheon 24341, Korea. FAU - Lee, Se Jin AU - Lee SJ AUID- ORCID: 0000-0002-8626-6250 AD - Department of Obstetrics and Gynecology, Kangwon National University School of Medicine, Chuncheon 24341, Korea. FAU - Ahn, Tae Gyu AU - Ahn TG AUID- ORCID: 0000-0002-5519-0572 AD - Department of Obstetrics and Gynecology, Kangwon National University School of Medicine, Chuncheon 24341, Korea. FAU - Son, Kyung Ho AU - Son KH AUID- ORCID: 0000-0002-2466-8334 AD - Department of AI Convergence, Kangwon National University, Chuncheon 24341, Korea. FAU - Kim, Woo Jin AU - Kim WJ AUID- ORCID: 0000-0003-2927-370X AD - Department of Medical Informatics, Kangwon National University School of Medicine, Chuncheon 24341, Korea. AD - Department of Internal Medicine and Environmental Health Center, Kangwon National University School of Medicine, Chuncheon 24341, Korea. FAU - Lee, Jung Eun AU - Lee JE AUID- ORCID: 0000-0003-1141-878X AD - Department of Food and Nutrition, College of Human Ecology, Seoul National University, Seoul 08826, Korea. AD - Research Institute of Human Ecology, Seoul National University, Seoul 08826, Korea. CN - Ko-CHENS Study Group LA - eng PT - Journal Article DEP - 20260918 PL - Korea (South) TA - Nutr Res Pract JT - Nutrition research and practice JID - 101311052 PMC - PMC13669475 OTO - NOTNLM OT - Diet surveys OT - comparative study OT - nutrition assessment OT - pregnancy COIS- Conflict of Interest: The authors declare no potential conflicts of interests. EDAT- 2026/10/17 23:12 MHDA- 2026/10/17 23:13 PMCR- 2026/10/01 CRDT- 2026/10/17 11:09 PHST- 2026/04/18 00:00 [received] PHST- 2026/08/07 00:00 [revised] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/10/17 23:13 [medline] PHST- 2026/10/17 23:12 [pubmed] PHST- 2026/10/17 11:09 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.4162/nrp.2026.20.5.866 [doi] PST - ppublish SO - Nutr Res Pract. 2026 Oct;20(5):866-878. doi: 10.4162/nrp.2026.20.5.866. Epub 2026 Sep 18. PMID- 42889402 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Association between discretionary screen time and depressive symptoms in Chinese adolescents: a cross-sectional study. PG - 1957282 LID - 10.3389/fped.2026.1957282 [doi] LID - 1957282 AB - BACKGROUND: Adolescents globally exhibit growing engagement with discretionary screen time, but its association with depressive symptoms remains unclear in developing economies. OBJECTIVE: To examine the relationship between discretionary screen time and depressive symptoms among Chinese adolescents. METHODS: A cross-sectional study of 4,706 adolescents in Maoming City, Guangdong Province, China. Participants were stratified into four discretionary screen time categories: <1 h (n = 1,372), 1-2 h (n = 1,277), 2-4 h (n = 1,032), and >/=4 h (n = 1,025). Depressive symptoms were assessed using the validated CESD-9, with a cutoff score of >/=10. The primary analysis was a multilevel logistic regression model with random intercepts for school and class, adjusted for all measured covariates except BMI, anxiety and insomnia; a model additionally adjusted for BMI, anxiety and insomnia served as a sensitivity analysis. Subgroup analyses evaluated potential effect modification. RESULTS: The prevalence of depressive symptoms was 29.7% (1,398/4,706). In the primary multilevel model (random intercepts for school and class; adjusted for sociodemographic, socioeconomic and lifestyle factors, without BMI, anxiety and insomnia), compared with the <1 h reference group, the odds ratios were 1.21 (95% CI: 0.98-1.49; p = 0.082) for 1-2 h, 1.88 (95% CI: 1.52-2.33; p < 0.001) for 2-4 h, and 2.54 (95% CI: 2.04-3.16; p < 0.001) for >/=4 h; each screen-time category increment was associated with 39% higher odds of depressive symptoms (OR = 1.39, 95% CI: 1.29-1.49; p < 0.001). When additionally adjusted for BMI, anxiety and insomnia (sensitivity analysis, Model 4), the associations were attenuated but remained statistically significant for the higher categories (>/=4 h: OR = 1.69, 95% CI: 1.28-2.22; per-category OR = 1.19, 95% CI: 1.09-1.29). Subgroup analyses revealed no statistically significant evidence of effect modification (all p-interaction >0.05). CONCLUSION: Prolonged discretionary screen time is significantly associated with higher odds of depressive symptoms among Chinese adolescents, indicating a graded association that strengthens with increasing screen time. These findings are relevant to public-health monitoring of discretionary screen use in adolescents. CI - (c) 2026 Xu, Yang, Wang and Wang. FAU - Xu, Zhi AU - Xu Z AD - Department of Neurosis and Psychosomatic Diseases, The Third Hospital of Quzhou, Quzhou, Zhejiang, China. FAU - Yang, Shuye AU - Yang S AD - Department of Neurology, Binzhou People's Hospital, Binzhou, Shandong, China. FAU - Wang, Shibin AU - Wang S AD - Guangdong Mental Health Center, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China. FAU - Wang, Xing AU - Wang X AD - Department of Neurosis and Psychosomatic Diseases, Huzhou Third Municipal Hospital, The Affiliated Hospital of Huzhou Normal University, Huzhou, Zhejiang, China. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13669189 OTO - NOTNLM OT - Chinese adolescents OT - adolescents OT - cross-sectional study OT - depressive symptoms OT - discretionary screen time COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:12 MHDA- 2026/10/17 23:13 PMCR- 2026/10/01 CRDT- 2026/10/17 10:56 PHST- 2026/08/03 00:00 [received] PHST- 2026/09/17 00:00 [revised] PHST- 2026/09/22 00:00 [accepted] PHST- 2026/10/17 23:13 [medline] PHST- 2026/10/17 23:12 [pubmed] PHST- 2026/10/17 10:56 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.3389/fped.2026.1957282 [doi] PST - epublish SO - Front Pediatr. 2026 Oct 1;14:1957282. doi: 10.3389/fped.2026.1957282. eCollection 2026. PMID- 42889302 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Team sport as a potential context for interpersonal emotion regulation in early adolescence: a quasi-experimental comparison with individual exercise. PG - 1948213 LID - 10.3389/fpsyt.2026.1948213 [doi] LID - 1948213 AB - OBJECTIVE: Emotion regulation deficits are a transdiagnostic risk factor for adolescent emotional disorders. This quasi-experimental study examined whether different exercise contexts were associated with intrapersonal and interpersonal emotion regulation in early adolescents. METHODS: A quasi-experimental cluster-allocated design was conducted with 114 sixth-grade students from three intact classes, with each class allocated to one of three conditions: team exercise, individual exercise, or control condition. Participants completed measures of emotion regulation at pre-test, mid-test, and post-test during an 8-week intervention. RESULTS: Team exercise was associated with a significantly different trajectory of interpersonal emotion regulation over time compared with individual exercise and control conditions, with the team exercise group showing a more favorable pattern of change. Changes in expressive suppression showed a small negative association with changes in interpersonal emotion regulation. CONCLUSION: Team-based cooperative exercise may provide a potentially relevant context for supporting interpersonal emotion regulation in early adolescents, although the association involving expressive suppression should be interpreted cautiously given the low reliability of this subscale. CI - Copyright (c) 2026 Li, You, Tao, Yang and Yu. FAU - Li, Xilin AU - Li X AD - School of Sport Training, Chengdu Sport University, Chengdu, China. FAU - You, Qiuping AU - You Q AD - School of Sport Training, Chengdu Sport University, Chengdu, China. FAU - Tao, Yunfei AU - Tao Y AD - School of Sport Training, Chengdu Sport University, Chengdu, China. FAU - Yang, Chengbo AU - Yang C AD - School of Sport Training, Chengdu Sport University, Chengdu, China. FAU - Yu, Dawei AU - Yu D AD - School of Teacher Education (Physical Education), Taizhou University, Taizhou, China. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13668848 OTO - NOTNLM OT - cognitive reappraisal OT - early adolescents OT - expressive suppression OT - individual exercise OT - interpersonal emotion regulation OT - team exercise COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:12 MHDA- 2026/10/17 23:13 PMCR- 2026/10/01 CRDT- 2026/10/17 09:59 PHST- 2026/07/25 00:00 [received] PHST- 2026/09/06 00:00 [revised] PHST- 2026/09/20 00:00 [accepted] PHST- 2026/10/17 23:13 [medline] PHST- 2026/10/17 23:12 [pubmed] PHST- 2026/10/17 09:59 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1948213 [doi] PST - epublish SO - Front Psychiatry. 2026 Oct 1;17:1948213. doi: 10.3389/fpsyt.2026.1948213. eCollection 2026. PMID- 42889239 OWN - NLM STAT- MEDLINE DCOM- 20261017 LR - 20261019 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Regional differences in obesity risk, sedentary behavior, and dietary patterns among university students in Saudi Arabia: a multi-region cross-sectional study. PG - 1980253 LID - 10.3389/fpubh.2026.1980253 [doi] LID - 1980253 AB - BACKGROUND: Overweight and obesity are rising among Saudi university students. Guided by Popkin's nutrition transition theory, this study examined regional variation in overweight/obesity, sedentary behavior, and nutrition-transition dietary patterns. METHODS: This cross-sectional study (March-May 2023) recruited 564 students from four Saudi administrative regions using a multistage sampling approach. Three colleges per university were selected across three academic domains; within each college, one male and one female class per academic level were invited; all eligible students completed the questionnaire. Students with prior type 2 diabetes were excluded. BMI was calculated from self-reported weight and height (overweight/obesity: >/= 25.0 kg/m(2)). Dietary patterns were identified using principal-component analysis of 17 food groups from a validated 66-item food frequency questionnaire. Physical activity was assessed via IPAQ-SF (sufficient: >/= 150 min/week); composite sedentary behavior exposure was classified as low (< 8 h/day), moderate (8-12 h/day), or high (> 12 h/day). Logistic regression adjusted for sex, age, income, college type, region, and smoking. RESULTS: Overweight/obesity prevalence was 17.9% (n = 100/558); as BMI relied on self-reported anthropometrics, this is a conservative lower bound. A marked regional gradient was observed: 27.8% of Riyadh students were overweight/obese versus 8.8% in Makkah (chi (2) = 25.48, p < 0.001). Region showed the strongest association with overweight/obesity after adjustment: Riyadh (aOR = 4.62, 95% CI 2.23-9.59, p < 0.001) and male sex (aOR = 1.96, 95% CI 1.04-3.71, p = 0.037) were the only significant predictors. Composite sedentary behavior exposure was high: 82.3% were moderately or highly sedentary (>/= 8 h/day), dominated by mobile phone use (3.75 h/day) and academic study (3.35 h/day). Sedentary behavior was higher in overweight/obese students (15.5 vs. 13.9 h/day; p = 0.043). Nutrition-transition dietary patterns were not associated with overweight/obesity (aOR = 0.93, p = 0.543). CONCLUSION: Region showed the strongest association with overweight/obesity, with Riyadh students at four-fold higher risk than Makkah students, suggesting that regional structural and environmental factors may contribute to obesity risk in this population. Prolonged mobile phone use and screen-based sedentarism were prevalent and associated with overweight/obesity. Campus interventions targeting sedentary screen behavior and regional food environments, particularly in Riyadh, are warranted; future studies should employ direct anthropometry to obtain unbiased prevalence estimates. CI - Copyright (c) 2026 Alkhraiji and Alaqil. FAU - Alkhraiji, Mohummed H AU - Alkhraiji MH AD - Department of Exercise Physiology, College of Sport Sciences and Physical Activity, King Saud University, Riyadh, Saudi Arabia. FAU - Alaqil, Abdulrahman I AU - Alaqil AI AD - College of Education, Department of Physical Education, King Faisal University, Al-Ahsa, Saudi Arabia. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Male MH - Cross-Sectional Studies MH - Female MH - *Sedentary Behavior MH - *Obesity/epidemiology MH - *Students/statistics & numerical data MH - Universities MH - Young Adult MH - *Diet/statistics & numerical data MH - Prevalence MH - Risk Factors MH - Adult MH - *Feeding Behavior MH - Surveys and Questionnaires MH - Overweight/epidemiology MH - Body Mass Index MH - Exercise MH - Adolescent PMC - PMC13668806 OTO - NOTNLM OT - Saudi Arabia OT - dietary patterns OT - nutrition transition OT - obesity OT - overweight OT - regional variation OT - sedentary behavior OT - self-reported BMI COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:13 MHDA- 2026/10/17 23:14 PMCR- 2026/10/01 CRDT- 2026/10/17 09:27 PHST- 2026/08/27 00:00 [received] PHST- 2026/09/18 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/17 23:14 [medline] PHST- 2026/10/17 23:13 [pubmed] PHST- 2026/10/17 09:27 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1980253 [doi] PST - epublish SO - Front Public Health. 2026 Oct 1;14:1980253. doi: 10.3389/fpubh.2026.1980253. eCollection 2026. PMID- 42889191 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Does learning burnout link physical exercise and problematic short-video use? Evidence from a three-wave random-intercept cross-lagged panel model and supplementary machine-learning analysis among Chinese high school students. PG - 1929181 LID - 10.3389/fpsyg.2026.1929181 [doi] LID - 1929181 AB - BACKGROUND: Problematic short-video use has become a growing behavioral health concern among adolescents, yet its longitudinal links with physical exercise and learning burnout remain insufficiently understood. This study examined the within-person bidirectional associations among physical exercise, learning burnout, and problematic short-video use, tested whether learning burnout served as a longitudinal pathway linking physical exercise to later problematic short-video use, and explored the predictive value of these variables for subsequent problematic short-video use. METHODS: A three-wave longitudinal survey with 6-month intervals was conducted among 1,327 students aged 16-18 years from five high schools in Yunnan Province, China. Physical exercise, learning burnout, and problematic short-video use were assessed using the Physical Activity Rating Scale-3 (PARS-3), the Adolescent Student Burnout Inventory, and the Short-Video Addiction Scale. Random-intercept cross-lagged panel modeling was used to separate stable between-person differences from within-person fluctuations while controlling for demographic and educational covariates. The longitudinal indirect association was estimated using 5,000 bias-corrected bootstrap samples. Supplementary ridge regression and extreme gradient boosting models, using nested cross-validation and a holdout test set, examined the incremental predictive value of physical exercise and learning burnout for later problematic short-video use. RESULTS: At the between-person level, higher long-term physical exercise was associated with lower learning burnout and problematic short-video use, whereas higher learning burnout was associated with higher problematic short-video use. At the within-person level, higher-than-usual physical exercise predicted lower subsequent learning burnout and problematic short-video use. Learning burnout and problematic short-video use showed positive reciprocal associations over time, and both predicted lower subsequent physical exercise. The longitudinal indirect association from physical exercise to later problematic short-video use through learning burnout was statistically significant but small. In supplementary machine-learning analyses, the best holdout R (2) was 0.311, but adding physical exercise and learning burnout did not improve prediction beyond prior problematic short-video use. SHAP results from the extended XGBoost model were therefore interpreted as exploratory feature attributions. CONCLUSION: Physical exercise, learning burnout, and problematic short-video use showed interconnected longitudinal associations among Chinese high school students. Learning burnout may represent one small longitudinal indirect pathway linking physical exercise to later problematic short-video use, while recent problematic short-video use provides the most informative signal for future risk. These findings may inform the development and evaluation of school-based health-promotion strategies that support physical exercise, address learning burnout, and respond to recent problematic-use symptoms. CI - Copyright (c) 2026 Yin, Peng, Chen, Wang, Liu, Xie and Gao. FAU - Yin, Tian AU - Yin T AD - Xiangtan University, Xiangtan, Hunan, China. AD - School of Physical Education, Yunnan Minzu University, Kunming, Yunnan, China. FAU - Peng, Yanfeng AU - Peng Y AD - School of Physical Education, Yunnan Minzu University, Kunming, Yunnan, China. FAU - Chen, Longjiang AU - Chen L AD - School of Physical Education, Yunnan Normal University, Kunming, Yunnan, China. FAU - Wang, Zetian AU - Wang Z AD - School of Physical Education, Yunnan Minzu University, Kunming, Yunnan, China. FAU - Liu, Xu AU - Liu X AD - School of Physical Education, Yunnan Minzu University, Kunming, Yunnan, China. FAU - Xie, Changcheng AU - Xie C AD - Hezhou University, Hezhou, Guangxi, China. FAU - Gao, Zeng AU - Gao Z AD - Xiangtan University, Xiangtan, Hunan, China. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13668801 OTO - NOTNLM OT - high school students OT - learning burnout OT - machine learning OT - physical exercise OT - problematic short-video use OT - random-intercept cross-lagged panel model COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:13 MHDA- 2026/10/17 23:14 PMCR- 2026/10/01 CRDT- 2026/10/17 08:49 PHST- 2026/07/05 00:00 [received] PHST- 2026/08/30 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/10/17 23:14 [medline] PHST- 2026/10/17 23:13 [pubmed] PHST- 2026/10/17 08:49 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1929181 [doi] PST - epublish SO - Front Psychol. 2026 Oct 1;17:1929181. doi: 10.3389/fpsyg.2026.1929181. eCollection 2026. PMID- 42889007 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Policy themes and instruments in WHO and UNICEF child food-environment guidance, 2015-2025: a computational content analysis. PG - 1935052 LID - 10.3389/fnut.2026.1935052 [doi] LID - 1935052 AB - In children's food environments, global guidance can shape policy discourse and instrument choice, but its content does not establish implementation or outcomes. In 2015-2025, the World Health Organization (WHO) and the United Nations Children's Fund (UNICEF) published English-language guidance at the global level. A documented search, 2-author screening, and author-decision-masked expert review produced a corpus of 22 expert-refrozen documents (1,099 pages; 1,259 primary chunks). The BERTopic with document-capped discovery yielded six provisional clusters: food-marketing restrictions and children's rights; obesity burden; nutrition-sensitive social protection and service delivery; school, physical activity, and healthy food environments; infant and young child food promotion controls; and business engagement and food-industry governance. Among 978 chunks, marketing restrictions and children's rights accounted for 332 assigned chunks (33.9%). The expert accepted all descriptors and changed three of seven boundary decisions; applying those decisions and rerunning the full pipeline retained six identity-mapped clusters. Fixed-corpus seed and zoning diagnostics were favorable, but context expansion produced seven clusters and dominant-source removal substantially reorganized two source-concentrated clusters. To assess coding reliability, an 84-chunk exercise was archived under the earlier 19-document freeze; issuer and period profiles were descriptive. The study therefore provides a bound, auditable map rather than a stable taxonomy. Nutritional health literacy is a downstream interpretive application: no actual implementation process or literacy, behavioral, dietary-quality, or health outcome was measured. CI - Copyright (c) 2026 Xing and Wu. FAU - Xing, Lu AU - Xing L AD - School of Preschool Education, Changsha Normal University, Changsha, China. AD - School of Education, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. FAU - Wu, Xueqi AU - Wu X AD - Taylor's Culinary Institute, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13668553 OTO - NOTNLM OT - BERTopic OT - child nutrition OT - computational content analysis OT - food environments OT - food governance OT - nutritional health literacy OT - policy discourse OT - policy implementation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/17 23:13 MHDA- 2026/10/17 23:14 PMCR- 2026/10/01 CRDT- 2026/10/17 06:11 PHST- 2026/07/11 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/10/17 23:14 [medline] PHST- 2026/10/17 23:13 [pubmed] PHST- 2026/10/17 06:11 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 10.3389/fnut.2026.1935052 [doi] PST - epublish SO - Front Nutr. 2026 Oct 1;13:1935052. doi: 10.3389/fnut.2026.1935052. eCollection 2026. PMID- 42888994 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261017 LR - 20261019 IS - 3067-3534 (Electronic) IS - 3067-3518 (Print) IS - 3067-3518 (Linking) VI - 1 IP - 4 DP - 2026 Jul-Aug TI - Feasibility, Acceptability, and Efficacy of Using a Mobile Health Application for Lifestyle Modification in Youth With Prediabetes: A Prosper App Study. PG - 601-608 LID - 10.2337/doc26-0026 [doi] AB - OBJECTIVE: Mobile health (mHealth) applications (apps) help individuals achieve healthy lifestyle behaviors. We assessed feasibility, acceptability, and efficacy of an mHealth app, Prosper, in helping adolescents with prediabetes track and achieve lifestyle modifications. RESEARCH DESIGN AND METHODS: This prospective pilot study enrolled adolescents aged 13-17 years with prediabetes. Participants downloaded the Prosper app and use was followed for 3 months after a prediabetes visit. App use, check-ins, and habits data were analyzed; surveys assessed feasibility, acceptability, and participant-reported efficacy. Primary outcomes were use and feasibility or acceptability of the app. Secondary outcomes included changes in BMI and hemoglobin A(1c) (HbA(1c)). Caregivers and providers were also surveyed. RESULTS: The study enrolled 25 participants (median age 15.1 years; 76% female; 64% identified as Black adolescents; 76% identifed as non-Hispanic; and 56% had Medicaid insurance). Participants completed 2,057 habits, 575 check-ins, and 114 journals overall. The median number of check-ins per participant was 4 (interquartile range 2-18), and 36% completed >/=12 check-ins. Most participants (68%) set at least 2 habits, with a maximum of 14 habits. High satisfaction was reported by 74-87%. Most found the app easy to use (95.7-100%), helpful for tracking nutrition (61-78%) and exercise (56.5-86%), and easy to integrate into daily routines (52-73%). Baseline median BMI was 37.7 kg/m(2) (interquartile range 32.0-43.3) and HbA(1c) was 5.7% (interquartile range 5.6-5.8), without change noted after 3 months. CONCLUSIONS: Adolescents reported high satisfaction with the Prosper app and found it easy to use, helpful for tracking nutrition and exercise goals, and easy to incorporate into daily routines. mHealth tools may support adolescent lifestyle modifications between clinical visits with broad scalability. CI - (c) 2026 by the American Diabetes Association. FAU - Wang, Cynthia AU - Wang C AUID- ORCID: 0009-0003-9246-6595 AD - Division of Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. FAU - Parimi, Neha AU - Parimi N AUID- ORCID: 0000-0003-1338-8270 AD - Division of Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. FAU - Patel, Dhruva AU - Patel D AD - Division of Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. FAU - Williams, Hannah AU - Williams H AD - Division of Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. FAU - Malina, Sara N AU - Malina SN AD - Division of Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. FAU - Wolf, Risa M AU - Wolf RM AUID- ORCID: 0000-0001-7674-520X AD - Division of Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. FAU - Hitt, Talia A AU - Hitt TA AUID- ORCID: 0000-0003-4491-3648 AD - Division of Endocrinology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD. LA - eng SI - figshare/10.2337/figshare.32249199 PT - Journal Article DEP - 20260629 PL - United States TA - Diabetes Obes Cardiometab CARE JT - Diabetes, obesity, and cardiometabolic CARE JID - 9919229522706676 PMC - PMC13644839 COIS- R.M.W. previously served in an unpaid advisory role to Uneo Inc. ("Uneo Health"), the company that developed the mobile application evaluated in this study. R.M.W. reports receiving research support from Lilly Diabetes, Novo Nordisk, and Sanofi unrelated to the submitted work. No other potential conflicts of interest relevant to this article were reported. EDAT- 2026/10/17 23:12 MHDA- 2026/10/17 23:13 PMCR- 2026/06/29 CRDT- 2026/10/17 06:02 PHST- 2026/02/24 00:00 [received] PHST- 2026/05/05 00:00 [accepted] PHST- 2026/10/17 23:13 [medline] PHST- 2026/10/17 23:12 [pubmed] PHST- 2026/10/17 06:02 [entrez] PHST- 2026/06/29 00:00 [pmc-release] AID - 260026 [pii] AID - 10.2337/doc26-0026 [doi] PST - epublish SO - Diabetes Obes Cardiometab CARE. 2026 Jun 29;1(4):601-608. doi: 10.2337/doc26-0026. eCollection 2026 Jul-Aug. PMID- 42886664 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 10 DP - 2026 TI - Validation of HemoCue method and development of a revised hemoglobin cut-off to detect anemia in children aged 6-24-months. PG - e0346506 LID - 10.1371/journal.pone.0346506 [doi] LID - e0346506 AB - BACKGROUND: Accurate hemoglobin (Hb) measurement is essential for determining anemia prevalence at the population level. The HemoCue method, commonly used in resource poor settings, has been shown to overestimate Hb levels compared to the direct cyanmethemoglobin (DCM) method, leading to an underestimation of anemia. We aimed to validate the HemoCue method against the DCM method and establish an optimal cut-off value for diagnosing anemia in children under two. METHODS: Data were collected from children under two years of age as part of the Etiology, Risk Factors, and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development study in Bangladesh, conducted in Mirpur, Dhaka, from February 2010 to February 2017. Using HemoCue 201 instrument and DCM method, Hb levels were measured in 846 venous blood samples collected from 589 children. Quadratic regression was explored to derive a correction factor; however, substantial dispersion in HemoCue measurements prevented establishment of a reliable correction model. Youden's Index was used to identify the optimal cut‑off. While it provided a strong threshold, we prioritized achieving at least 70% sensitivity and specificity to confirm balanced diagnostic performance. RESULTS: The median (IQR) Hb concentrations estimated by HemoCue and DCM were 11.6 (10.5, 12.5) g/dL and 10.8 (10.1, 11.5) g/dL, respectively. Using a cut-off of <10.5 g/dL for anemia, the prevalence was significantly higher with the DCM method (35.2% vs. 23.2%, p < 0.001). Considering DCM as the gold standard, the sensitivity and specificity of the HemoCue method were 93% and 53%, respectively. In the test/train analysis, the newly identified cut-off of 11.00 g/dL, indicated an anemia prevalence of 34.2% in the testing dataset, with a sensitivity of 84% and specificity of 69%. CONCLUSION: This study highlights substantial variability between HemoCue and DCM hemoglobin measurements, which prevented development of a reliable correction factor. The proposed HemoCue cut-off of 11.0 g/dL may improve anemia detection in children under two years of age when compared with the currently recommended threshold. CI - Copyright: (c) 2026 Mahfuz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Mahfuz, Mustafa AU - Mahfuz M AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Khan, Ar-Rafi AU - Khan AR AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Hasan, S M Tafsir AU - Hasan SMT AUID- ORCID: 0000-0002-6062-4072 AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Hossain, Md Shabab AU - Hossain MS AUID- ORCID: 0000-0002-2862-8639 AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Rezwan, A H M AU - Rezwan AHM AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Mahfuz, Mehjabin Tishan AU - Mahfuz MT AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Alam, Md Ashraful AU - Alam MA AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. FAU - Ahmed, Tahmeed AU - Ahmed T AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. AD - Office of Executive Director, International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b), Dhaka, Bangladesh. LA - eng PT - Journal Article PT - Validation Study DEP - 20261016 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Hemoglobins) SB - IM MH - Humans MH - *Hemoglobins/analysis MH - *Anemia/diagnosis/blood/epidemiology MH - Infant MH - Male MH - Child, Preschool MH - Female MH - Sensitivity and Specificity MH - Bangladesh/epidemiology MH - Prevalence PMC - PMC13674700 COIS- The authors have declared that no competing interests exist. EDAT- 2026/10/16 19:05 MHDA- 2026/10/16 19:06 PMCR- 2026/10/16 CRDT- 2026/10/16 13:35 PHST- 2026/03/20 00:00 [received] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/10/16 19:06 [medline] PHST- 2026/10/16 19:05 [pubmed] PHST- 2026/10/16 13:35 [entrez] PHST- 2026/10/16 00:00 [pmc-release] AID - PONE-D-26-09930 [pii] AID - 10.1371/journal.pone.0346506 [doi] PST - epublish SO - PLoS One. 2026 Oct 16;21(10):e0346506. doi: 10.1371/journal.pone.0346506. eCollection 2026. PMID- 42885213 OWN - NLM STAT- Publisher LR - 20261028 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) DP - 2026 Oct 15 TI - Multimodal prediction of infliximab initiation within 6 months after initiation of conventional therapy in pediatric Crohn's disease: A multicenter algorithm development and validation study. LID - 10.1002/jpn3.70602 [doi] AB - OBJECTIVES: Early prediction of treatment course in pediatric Crohn's disease (CD) remains limited despite the importance of timely biologic therapy. We developed and externally validated a multimodal model integrating colonoscopy images and clinical data to predict infliximab initiation within 6 months after conventional therapy. METHODS: We collected data from children newly diagnosed with CD at three hospitals: Seoul National University Bundang Hospital for internal validation, Kyung Hee University Medical Center, and Soonchunhyang University Bucheon Hospital for external validation. Each patient contributed 7 endoscopic images and 20 clinical variables. An attention-based multiple-instance learning framework aggregated endoscopic images into a patient-level representation and integrated them with clinical features. The imaging encoder used a ResNet-50 backbone pretrained with momentum contrastive learning on GastroNet-5M, and clinical features were encoded using a multilayer perceptron. Performance was assessed using the area under the receiver operating characteristic curve (AUROC), balanced accuracy, precision, recall, and F1 score. Explainable AI was evaluated using attention maps (image data) and SHAP values (tabular data). RESULTS: Seventy-seven children were included for model development and internal validation, with external validation performed in two independent cohorts (n = 10 and n = 20). The multimodal model achieved an AUROC of 0.839 and balanced accuracy of 0.732 in the discovery cohort. External-validation AUROCs were 0.857 and 0.688. SHapley Additive exPlanation analysis identified immunoglobulin G, body mass index, prealbumin, hematocrit, and age as key predictors. Attention maps highlighted inflamed mucosa and ulcerative lesions. CONCLUSION: A multimodal model integrating colonoscopy images with clinical data showed promising performance for predicting infliximab initiation within 6 months after conventional therapy in pediatric CD. Multimodal information may support early risk stratification and identify patients who could benefit from earlier biologic intervention. CI - (c) 2026 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Kim, Seon Young AU - Kim SY AUID- ORCID: 0000-0001-6433-0242 AD - Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, South Korea. FAU - Hwang, Seung Ha AU - Hwang SH AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Electronics and Information Convergence Engineering, Kyung Hee University, Yongin, South Korea. FAU - Yeo, Dongjin AU - Yeo D AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. FAU - Kim, Juyeong AU - Kim J AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Regulatory Science, Kyung Hee University, Seoul, South Korea. FAU - Hwangbo, Gyeom AU - Hwangbo G AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. FAU - Kim, Do Hyun AU - Kim DH AUID- ORCID: 0000-0003-0064-1732 AD - Department of Pediatrics, Soonchunhyang University Seoul Hospital, Seoul, Korea. FAU - Lee, Yoo Min AU - Lee YM AD - Department of Pediatrics, Soonchunhyang University Bucheon Hospital, Bucheon, Korea. FAU - Woo, Selin AU - Woo S AUID- ORCID: 0000-0001-7961-2074 AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. FAU - Hahn, Jong Woo AU - Hahn JW AUID- ORCID: 0000-0001-6331-1314 AD - Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea. AD - Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, South Korea. FAU - Yon, Dong Keon AU - Yon DK AUID- ORCID: 0000-0003-1628-9948 AD - Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University School of Medicine, Seoul, South Korea. AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Electronics and Information Convergence Engineering, Kyung Hee University, Yongin, South Korea. AD - Department of Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Regulatory Science, Kyung Hee University, Seoul, South Korea. AD - Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. LA - eng GR - RS-2024-00509257/Ministry of Science and ICT, South Korea/ GR - IITP-2026-RS-2024-00438239/Ministry of Science and ICT, South Korea/ GR - RS-2025-02220492/Ministry of Health and Welfare/ PT - Journal Article DEP - 20261015 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM OTO - NOTNLM OT - SHAP OT - biologic therapy OT - endoscopic imaging OT - inflammatory bowel disease EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:33 CRDT- 2026/10/16 02:23 PHST- 2026/09/09 00:00 [revised] PHST- 2026/06/08 00:00 [received] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 05:33 [medline] PHST- 2026/10/16 02:23 [entrez] AID - 10.1002/jpn3.70602 [doi] PST - aheadofprint SO - J Pediatr Gastroenterol Nutr. 2026 Oct 15. doi: 10.1002/jpn3.70602. PMID- 42884734 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 6 TI - Lipid-Adjusted Vitamin E Status in Children with Chronic Liver Disease: Reclassification Patterns and Differences According to Cholestasis and Liver Transplantation. LID - 10.3390/nu18193283 [doi] LID - 3283 AB - BACKGROUND: Serum alpha-tocopherol depends on lipids, so absolute concentrations misclassify vitamin E status in children with chronic liver disease (CLD). The CALIPER program defined lipid-adjusted E:cholesterol (E:C) and E:triglyceride (E:TG) ratios, but their application in mixed-etiology pediatric CLD using immunoassay has not been reported. METHODS: Exploratory single-center cross-sectional study of 66 children (observed age range 4 months-17.9 years) with mixed-etiology CLD. Retinol and total vitamin E were measured by ELISA, whereas the CALIPER reference intervals applied here were established for alpha-tocopherol measured by HPLC; the two platforms are not interchangeable, so every classification reported is an exploratory application of those cutoffs. Vitamin E status was classified by absolute concentration, E:C (<3.7) and E:TG (<8.5). Cholestatic (n = 15), non-cholestatic (n = 45) and post-transplant (n = 6) groups were compared. RESULTS: Vitamin A was largely preserved (5.2% below WHO). Vitamin E was low in 45.3% by absolute concentration, 62.5% by E:C and 43.8% by E:TG. Of 35 children with a normal absolute vitamin E concentration, 11 (31.4%) were reclassified as low by E:C. Low E:C differed across groups (cholestatic 78.6%, non-cholestatic 63.6%, post-transplant 16.7%; p = 0.030). E:TG was inversely correlated with 25(OH)D (rho = -0.45; p < 0.001). CONCLUSIONS: Lipid-adjusted interpretation reclassified a substantial proportion of children whose absolute vitamin E concentration appeared adequate, and the prevalence of a low E:C ratio was lower among post-transplant participants than in the other two groups. In this exploratory cohort, the E:C ratio showed greater potential than the E:TG ratio for lipid-adjusted interpretation of vitamin E status; prospective validation against HPLC-based measurements and established functional indices is required before routine clinical adoption. FAU - Adam, Sorina AU - Adam S AUID- ORCID: 0000-0002-2074-0714 AD - "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania. FAU - Grama, Alina AU - Grama A AD - 2nd Pediatric Discipline, Department of Mother and Child, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania. AD - 2nd Pediatric Clinic, Emergency Clinical Hospital for Children, 400124 Cluj-Napoca, Romania. FAU - Mititelu, Alexandra AU - Mititelu A AUID- ORCID: 0000-0002-0955-4486 AD - 2nd Pediatric Discipline, Department of Mother and Child, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania. AD - 2nd Pediatric Clinic, Emergency Clinical Hospital for Children, 400124 Cluj-Napoca, Romania. FAU - Benta, Gabriel AU - Benta G AUID- ORCID: 0000-0002-2099-8379 AD - 2nd Pediatric Discipline, Department of Mother and Child, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania. AD - 2nd Pediatric Clinic, Emergency Clinical Hospital for Children, 400124 Cluj-Napoca, Romania. FAU - Chereches, Razvan M AU - Chereches RM AD - HIVE Health Innovation Center, Babes-Bolyai University, 400095 Cluj-Napoca, Romania. FAU - Pop, Tudor Lucian AU - Pop TL AUID- ORCID: 0000-0002-4931-1219 AD - 2nd Pediatric Discipline, Department of Mother and Child, Faculty of Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania. AD - 2nd Pediatric Clinic, Emergency Clinical Hospital for Children, 400124 Cluj-Napoca, Romania. LA - eng GR - 771/60/11.01.2023 and 647/53/11.01.2024/Iuliu Hatieganu University of Medicine and Pharmacy/ GR - 100418/29.08.2025, SMIS code 350525/Ministry of Research and Innovation/ PT - Journal Article DEP - 20261006 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 1406-18-4 (Vitamin E) RN - 0 (Lipids) RN - H4N855PNZ1 (alpha-Tocopherol) RN - 11103-57-4 (Vitamin A) RN - 97C5T2UQ7J (Cholesterol) RN - 0 (Triglycerides) SB - IM MH - Humans MH - Child MH - Child, Preschool MH - Female MH - Infant MH - *Vitamin E/blood MH - Cross-Sectional Studies MH - Male MH - Adolescent MH - *Liver Transplantation MH - *Cholestasis/blood MH - *Liver Diseases/blood/surgery MH - Chronic Disease MH - *Lipids/blood MH - alpha-Tocopherol/blood MH - *Vitamin E Deficiency/blood MH - Vitamin A/blood MH - Cholesterol/blood MH - Triglycerides/blood MH - Nutritional Status PMC - PMC13666619 OTO - NOTNLM OT - cholestasis OT - fat-soluble vitamins OT - lipid-adjusted vitamin E OT - liver transplantation OT - pediatric chronic liver disease OT - vitamin E OT - vitamin E-to-cholesterol ratio OT - alpha-tocopherol COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/06 CRDT- 2026/10/16 01:10 PHST- 2026/08/15 00:00 [received] PHST- 2026/09/25 00:00 [revised] PHST- 2026/10/01 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - nu18193283 [pii] AID - nutrients-18-03283 [pii] AID - 10.3390/nu18193283 [doi] PST - epublish SO - Nutrients. 2026 Oct 6;18(19):3283. doi: 10.3390/nu18193283. PMID- 42884725 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 5 TI - Turkish Adaptation of the Clean Food Consumerism Scale: A Validity and Reliability Study. LID - 10.3390/nu18193274 [doi] LID - 3274 AB - Background: Clean food consumerism reflects consumers' preferences for foods perceived as natural, authentic, transparent, and health-promoting. This study aimed to culturally adapt the Clean Food Consumerism Scale (CFCS) into Turkish and evaluate its psychometric properties. Methods: The CFCS was translated, back-translated, reviewed by experts, pilot-tested, and psychometrically evaluated. For the pilot study and factor analyses, the Turkish version was administered to 1637 adults, who were allocated to three mutually exclusive subsamples: n = 180 for the pilot study, n = 500 for EFA, and n = 957 for CFA. An additional, separate sample of 124 participants completed the CFCS twice at a three-week interval for the test-retest analysis. Internal consistency, construct validity, convergent validity, discriminant validity, criterion validity, and test-retest reliability were assessed using Cronbach's alpha, item-total correlations, EFA, CFA, composite reliability (CR), average variance extracted (AVE), the Fornell-Larcker criterion, heterotrait-monotrait (HTMT) ratios, correlations with the Sustainable and Healthy Eating Behaviors Scale (SHEBS), and test-retest correlations. Results: The 18-item CFCS demonstrated excellent internal consistency (Cronbach's alpha = 0.948). Sampling adequacy was supported by the KMO value (0.927) and significant Bartlett's test (chi(2) = 7525.229, p < 0.001). EFA supported a five-factor structure comprising Perceived Health Benefits, Production Process Transparency, Authenticity, Perceived Ease of Use, and Familiarity, explaining 80.92% of the total variance. CFA supported the five-factor model. After adding one content-justified residual covariance between two closely related Perceived Health Benefits items, the final model showed acceptable fit (chi(2) = 641.39, df = 124, p < 0.001; CFI = 0.965, TLI = 0.956, NFI = 0.957, RMSEA = 0.066 [90% CI 0.061-0.071], SRMR = 0.047, GFI = 0.926, AGFI = 0.899). Standardized factor loadings ranged from 0.748 to 0.938, composite reliability from 0.873 to 0.940, and average variance extracted from 0.697 to 0.771. HTMT ratios for all factor pairs remained below 0.685 and the Fornell-Larcker criterion was satisfied for every factor, supporting discriminant validity. Test-retest reliability over three weeks was excellent (r = 0.889, p < 0.001), and CFCS scores were positively correlated with SHEBS scores (r = 0.441, p < 0.001). Conclusions: The Turkish version of the CFCS demonstrated strong validity, reliability, and temporal stability while preserving the original five-factor structure. It provides a psychometrically sound instrument for assessing clean food consumerism among Turkish-speaking adults and may support future research in nutrition, public health, sustainability, and consumer behavior. FAU - Sipahi Uygur, Simge AU - Sipahi Uygur S AUID- ORCID: 0000-0002-3070-0601 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. FAU - Cakir Bicer, Nihan AU - Cakir Bicer N AUID- ORCID: 0000-0002-7581-9083 AD - Department of Molecular Gastroenterology and Hepatology, Institute of Gastroenterology and Hepatology, Kocaeli University, Kocaeli 41001, Turkiye. FAU - Ones, Ece AU - Ones E AUID- ORCID: 0000-0002-9936-8475 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. FAU - Roberts, Sena AU - Roberts S AUID- ORCID: 0000-0002-6052-109X AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. FAU - Koksal, Selen AU - Koksal S AUID- ORCID: 0000-0002-1181-3619 AD - Department of Culinary, Vocational School, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. FAU - Turker, Perim Fatma AU - Turker PF AUID- ORCID: 0000-0002-4254-3711 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. FAU - Bas, Murat AU - Bas M AUID- ORCID: 0000-0002-0494-301X AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, Istanbul 34752, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20261005 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Turkey MH - Female MH - Reproducibility of Results MH - Male MH - Adult MH - Psychometrics MH - *Consumer Behavior MH - Middle Aged MH - Pilot Projects MH - Young Adult MH - Surveys and Questionnaires MH - *Diet, Healthy MH - *Food Preferences/psychology MH - Adolescent PMC - PMC13666638 OTO - NOTNLM OT - Turkish adaptation OT - clean food consumerism OT - psychometric evaluation OT - reliability OT - scale adaptation OT - sustainable nutrition OT - validity COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/05 CRDT- 2026/10/16 01:10 PHST- 2026/07/01 00:00 [received] PHST- 2026/09/21 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/05 00:00 [pmc-release] AID - nu18193274 [pii] AID - nutrients-18-03274 [pii] AID - 10.3390/nu18193274 [doi] PST - epublish SO - Nutrients. 2026 Oct 5;18(19):3274. doi: 10.3390/nu18193274. PMID- 42884723 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 5 TI - Association Between Eating Attitudes and Dental Caries Experience in Young Adults Attending a Private Dental Practice: A Cross-Sectional Study. LID - 10.3390/nu18193273 [doi] LID - 3273 AB - BACKGROUND/OBJECTIVES: Eating attitudes may be linked to oral health through behavioral and lifestyle mechanisms, but data on young adults remain limited. The primary objective was to assess the association between dietary attitudes and caries experience in young adults recruited from a private dental practice. Secondary analyses examined the psychometric properties of the EAT-40 and the relationships of its scores with BMI, oral health behaviors, and lifestyle factors. METHODS: A cross-sectional study included 366 adults aged 18-25 years recruited by convenience sampling from a private dental practice in Iasi. Eating attitudes were assessed using the EAT-40, oral health behaviors using the HU-DBI, and caries experience using the DMFT and DMFS indices. BMI was calculated based on self-reported weight and height. Exploratory factor analysis, Spearman correlations, negative binomial regression, and multiple linear regression were used. RESULTS: The EAT-40 showed good internal consistency (alpha = 0.887), and the three-factor solution explained 36.6% of the variance. The total EAT-40 score showed weak positive correlations with DMFT and DMFS (rho = 0.146; p = 0.005 for both), but was not significantly associated with DMFS in the fully adjusted model (IRR = 1.003; 95% CI: 0.997-1.010; p = 0.293) or in the sensitivity analysis (IRR = 1.005; 95% CI: 0.999-1.012; p = 0.122). None of the three EAT-40 dimensions was significantly associated with DMFS after adjustment. The total EAT-40 score was not significantly associated with BMI. Daily smoking was associated with higher DMFS values, whereas occasional smoking was not. CONCLUSIONS: In the study sample, EAT-40 scores were weakly associated with caries experience, but not independently with BMI. The results regarding EAT-40 dimensions remain exploratory, and the cross-sectional design does not allow for causal conclusions. FAU - Armencia, Adina Oana AU - Armencia AO AUID- ORCID: 0000-0003-0921-4382 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Nicolau, Andrei AU - Nicolau A AUID- ORCID: 0000-0002-1423-3820 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Vasluianu, Roxana Ionela AU - Vasluianu RI AUID- ORCID: 0000-0003-0867-1135 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Bolos, Alexandra AU - Bolos A AUID- ORCID: 0009-0007-1247-0383 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Balcos, Carina Ana-Maria AU - Balcos CA AUID- ORCID: 0000-0001-7712-1319 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Ioanid, Nicoleta AU - Ioanid N AUID- ORCID: 0009-0003-7558-3730 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Condurache, Gabriel AU - Condurache G AD - Private Dental Practice, 700106 Iasi, Romania. FAU - Vitalariu, Anca Mihaela AU - Vitalariu AM AUID- ORCID: 0000-0002-8341-8810 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Gradinaru, Irina AU - Gradinaru I AUID- ORCID: 0000-0002-1676-4668 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Macovei, Georgiana AU - Macovei G AUID- ORCID: 0000-0003-1152-4216 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. LA - eng PT - Journal Article DEP - 20261005 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - *Dental Caries/epidemiology/psychology MH - Young Adult MH - Male MH - Adult MH - Adolescent MH - *Feeding Behavior/psychology MH - Oral Health MH - Body Mass Index MH - DMF Index MH - Health Behavior MH - Life Style MH - Psychometrics PMC - PMC13666866 OTO - NOTNLM OT - body mass index OT - dental caries OT - feeding behavior OT - health behavior OT - young adult COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/05 CRDT- 2026/10/16 01:10 PHST- 2026/09/09 00:00 [received] PHST- 2026/09/30 00:00 [revised] PHST- 2026/10/02 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/05 00:00 [pmc-release] AID - nu18193273 [pii] AID - nutrients-18-03273 [pii] AID - 10.3390/nu18193273 [doi] PST - epublish SO - Nutrients. 2026 Oct 5;18(19):3273. doi: 10.3390/nu18193273. PMID- 42884717 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 3 TI - Association of Nutritional Status at Diagnosis with Disease Course in Pediatric Inflammatory Bowel Disease. LID - 10.3390/nu18193266 [doi] LID - 3266 AB - BACKGROUND: Growth impairment is a major component of pediatric inflammatory bowel disease (IBD), yet the prognostic role of baseline nutritional status remains debated. We assessed the impact of nutritional status at diagnosis on subsequent medical and surgical disease course. METHODS: We retrospectively studied 183 children with IBD (84 Crohn's disease, 99 ulcerative colitis) followed for at least 18 months. Patients were classified at diagnosis using BMI Z-scores as underweight (n = 35), normal weight (n = 123), or overweight/obese (n = 25). Multivariable regression models-adjusted for diagnosis, biological sex, age at diagnosis, and extraintestinal manifestations/comorbidities-evaluated relapse burden, surgical resection, and longitudinal anthropometric recovery at last follow-up. RESULTS: Baseline underweight status was not independently associated with a higher relapse burden or time to first relapse. A sensitivity analysis excluding surgically resected patients showed higher estimated relapse rates for underweight patients, though these did not reach statistical significance. In exploratory analyses, baseline underweight showed a borderline, non-significant association with subsequent surgical resection (adjusted OR 2.68, 95% CI 0.97-7.27; p = 0.056), warranting validation in larger prospective cohorts. Exploratory VEO-IBD analyses were limited by small subgroup size; within UC, a higher crude resection frequency was observed in VEO-UC than in older-onset UC (15.0% vs. 1.3%), but this finding should be interpreted cautiously. At follow-up, 85.7% of initially underweight patients reached normal weight. Higher baseline BMI Z-score was independently associated with higher follow-up BMI Z-score, whereas therapeutic escalation and total relapse burden were not independently associated with follow-up BMI Z-score. Persistent stunting was very rare (1.9%), precluding multivariable analysis. CONCLUSIONS: Baseline underweight showed a suggestive but non-significant association with subsequent surgical resection, warranting confirmation in larger prospective cohorts, while it was not independently associated with medical disease instability. Substantial weight recovery occurred during pediatric IBD follow-up. Baseline BMI Z-score was associated with BMI Z-score at follow-up, although substantial between-patient variability remained unexplained. FAU - Morelli, Annalisa AU - Morelli A AUID- ORCID: 0000-0002-9052-0266 AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. AD - Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", Pediatrics Section, University of Salerno, 84081 Baronissi, Italy. FAU - Caprarelli, Michela AU - Caprarelli M AUID- ORCID: 0000-0001-7166-6545 AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. AD - Department of Pediatrics, Universita Cattolica del Sacro Cuore, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00168 Rome, Italy. FAU - Ruiz, Roberta Giusy AU - Ruiz RG AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Mazzoli, Bianca AU - Mazzoli B AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. AD - Department of Pediatrics, Universita Cattolica del Sacro Cuore, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00168 Rome, Italy. FAU - Salatto, Alessia AU - Salatto A AUID- ORCID: 0000-0002-3613-4823 AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. AD - Department of Pediatrics, University Federico II of Naples, Via Sergio Pansini 5, 80131 Naples, Italy. FAU - Knafelz, Daniela AU - Knafelz D AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Bracci, Fiammetta AU - Bracci F AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Cardile, Sabrina AU - Cardile S AUID- ORCID: 0000-0003-2912-3154 AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Bolasco, Giulia AU - Bolasco G AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Trovato, Chiara Maria AU - Trovato CM AUID- ORCID: 0000-0003-3869-1815 AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - De Angelis, Paola AU - De Angelis P AD - Gastroenterology, Digestive Endoscopy and Nutrition Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Romeo, Erminia Francesca AU - Romeo EF AD - Gastroenterology, Digestive Endoscopy and Nutrition Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. FAU - Diamanti, Antonella AU - Diamanti A AD - Digestive Diseases and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), 00165 Rome, Italy. LA - eng PT - Journal Article DEP - 20261003 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - Pediatric Crohn's disease SB - IM MH - Humans MH - *Nutritional Status MH - Female MH - Male MH - Retrospective Studies MH - Child MH - Thinness/complications MH - Recurrence MH - Adolescent MH - *Colitis, Ulcerative/diagnosis/complications/physiopathology MH - Body Mass Index MH - Disease Progression MH - *Crohn Disease/diagnosis/complications/physiopathology MH - Prognosis MH - *Inflammatory Bowel Diseases/diagnosis/complications MH - Child, Preschool PMC - PMC13667242 OTO - NOTNLM OT - IBD OT - disease course OT - nutritional status COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/03 CRDT- 2026/10/16 01:10 PHST- 2026/08/23 00:00 [received] PHST- 2026/09/19 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/03 00:00 [pmc-release] AID - nu18193266 [pii] AID - nutrients-18-03266 [pii] AID - 10.3390/nu18193266 [doi] PST - epublish SO - Nutrients. 2026 Oct 3;18(19):3266. doi: 10.3390/nu18193266. PMID- 42884698 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 1 TI - Fit-Ideal Internalisation and Disordered Eating in Adolescent Girls: Psychometric Evaluation and Incremental Validity of the Fit Internalization Test. LID - 10.3390/nu18193248 [doi] LID - 3248 AB - OBJECTIVES: The present study aimed to validate the Lithuanian translation of the Fit Ideal Internalization Test (FIIT) in adolescent girls. METHODS: A total of 1067 girls (mean age = 17.27, SD = 0.61; age range = 15-19 years) participated in the study. FIIT, muscular ideal internalization, body dissatisfaction (BD), disordered eating (DE), body appreciation (BA), and exercise motivation were assessed. RESULTS: Exploratory factor analysis (n = 534) replicated the original three-factor structure, explaining 74.43% of the total variance. Confirmatory factor analysis (n = 533) supported the three-factor model, with strong factor loadings. Composite reliability was excellent (McDonald's omega = 0.919-0.969). Measurement invariance was established across sport participation groups, and sport-involved girls reported higher Fit Drive, Fit Overvaluation, and FIIT total scores than non-sport-involved girls. All FIIT subscales were positively associated with muscular internalization, BD, and DE and negatively associated with BA, while Fit Idealisation and Fit Overvaluation showed weak negative associations with autonomous exercise motivation, consistent with the hypothesised pattern of associations. The FIIT explained significant additional variance in DE beyond body mass index, BD, and muscular ideal internalization, with Fit Idealisation showing the strongest unique association (beta = 0.401, p < 0.001). CONCLUSIONS: The Lithuanian FIIT appears to be a psychometrically sound instrument for assessing fit ideal internalization among Lithuanian adolescent girls. FAU - Baceviciene, Migle AU - Baceviciene M AUID- ORCID: 0000-0002-9819-2316 AD - Department of Physical and Social Education, Lithuanian Sports University, Sporto 6, 44221 Kaunas, Lithuania. FAU - Balciuniene, Vaiva AU - Balciuniene V AUID- ORCID: 0000-0002-9986-9771 AD - Department of Physical and Social Education, Lithuanian Sports University, Sporto 6, 44221 Kaunas, Lithuania. FAU - Jankauskiene, Rasa AU - Jankauskiene R AUID- ORCID: 0000-0001-5950-0884 AD - Institute of Sport Science and Innovations, Lithuanian Sports University, Sporto 6, 44221 Kaunas, Lithuania. LA - eng PT - Journal Article PT - Validation Study DEP - 20261001 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adolescent MH - *Feeding and Eating Disorders/psychology/diagnosis MH - *Psychometrics MH - *Body Image/psychology MH - Reproducibility of Results MH - Young Adult MH - Body Satisfaction MH - Motivation MH - Exercise/psychology MH - Factor Analysis, Statistical MH - Lithuania MH - Body Dissatisfaction/psychology MH - Surveys and Questionnaires MH - Sports/psychology PMC - PMC13666705 OTO - NOTNLM OT - adolescent girls OT - body image OT - disordered eating OT - fit ideal internalization OT - measurement invariance OT - psychometric validation OT - sports COIS- The authors report no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/01 CRDT- 2026/10/16 01:10 PHST- 2026/09/01 00:00 [received] PHST- 2026/09/24 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - nu18193248 [pii] AID - nutrients-18-03248 [pii] AID - 10.3390/nu18193248 [doi] PST - epublish SO - Nutrients. 2026 Oct 1;18(19):3248. doi: 10.3390/nu18193248. PMID- 42884696 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 1 TI - Serum Zinc Concentrations and Dietary Zinc Adequacy in Children and Adolescents with Chronic Conditions: An Exploratory Secondary Analysis. LID - 10.3390/nu18193245 [doi] LID - 3245 AB - Background/Objectives: This secondary analysis evaluated the discordance between dietary adequacy and serum zinc levels in children and adolescents with chronic diseases, exploring the nutritional and biochemical traits of patients within an intermediate serum zinc range. Methods: Serum zinc was measured via atomic absorption spectrophotometry, and dietary tracking was conducted using a prospective 72 h food record. Subgroups were classified using Japanese Society of Clinical Nutrition thresholds (<60, 60-<80, and >/=80 mug/dL), treating the 60-<80 mug/dL band strictly as an operational, exploratory classification rather than a validated pediatric diagnostic standard. Results: Among the 90 participants, 31% fell into the 60-<80 mug/dL intermediate serum range and 61% exhibited inadequate dietary intake. Status discordance was frequent: 41% presented with inadequate dietary intake despite maintaining normal serum levels (>/=80 mug/dL), whereas 11% had intermediate serum levels despite achieving adequate dietary intake. There was no significant association between serum zinc concentration and dietary zinc intake. Operationally classified intermediate-range participants demonstrated several nutritional and biochemical differences, notably showing higher intakes of vitamins B6, D, and E, elevated triglycerides, ESR, and IgG3, alongside lower hemoglobin. Conclusions: Dietary adequacy and serum zinc levels are frequently discordant, reinforcing that these metrics serve as complementary rather than interchangeable indicators of zinc status. The distinct profiles observed within the operational 60-<80 mug/dL category provide candidate relationships that warrant future targeted investigation. FAU - Escobedo-Monge, Marlene Fabiola AU - Escobedo-Monge MF AUID- ORCID: 0000-0002-1295-3752 AD - Department of Pediatrics, Faculty of Medicine, University of Valladolid, Avenida Ramon y Cajal, 7, 47003 Valladolid, Spain. AD - International Cooperation for Health and Social Development (CIDESS) Group, University of Las Palmas de Gran Canaria, Calle Juan de Quesada, 30, 35001 Las Palmas de Gran Canaria, Spain. AD - Valladolid Health Research Institute (IBioVALL), C. Rondilla Sta. Teresa, 47010 Valladolid, Spain. FAU - Marugan-Miguelsanz, Jose Manuel AU - Marugan-Miguelsanz JM AD - Department of Pediatrics, Faculty of Medicine, University of Valladolid, Avenida Ramon y Cajal, 7, 47003 Valladolid, Spain. AD - Valladolid Health Research Institute (IBioVALL), C. Rondilla Sta. Teresa, 47010 Valladolid, Spain. AD - Section of Gastroenterology and Pediatric Nutrition, University Clinical Hospital of Valladolid, Avenida Ramon y Cajal, 3, 47003 Valladolid, Spain. FAU - Parodi Roman, Joaquin AU - Parodi Roman J AD - Science Faculty, University of Cadiz, Paseo de Carlos III, 28, 11003 Cadiz, Spain. FAU - Escobedo-Monge, Maria Antonieta AU - Escobedo-Monge MA AUID- ORCID: 0000-0001-6318-7333 AD - Department of Chemistry, Science Faculty, University of Burgos, Plaza Misael Banuelos SN, 09001 Burgos, Spain. FAU - Bahillo-Curieses, M Pilar AU - Bahillo-Curieses MP AD - Department of Pediatrics, Faculty of Medicine, University of Valladolid, Avenida Ramon y Cajal, 7, 47003 Valladolid, Spain. AD - Section of Gastroenterology and Pediatric Nutrition, University Clinical Hospital of Valladolid, Avenida Ramon y Cajal, 3, 47003 Valladolid, Spain. LA - eng PT - Journal Article DEP - 20261001 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - J41CSQ7QDS (Zinc) SB - IM MH - Humans MH - *Zinc/blood/deficiency/administration & dosage MH - Adolescent MH - Child MH - Female MH - Chronic Disease MH - Male MH - *Nutritional Status MH - *Diet MH - Prospective Studies MH - Secondary Data Analysis MH - Child, Preschool PMC - PMC13667015 OTO - NOTNLM OT - deficient zinc intake OT - low/intermediate zinc deficiency COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/01 CRDT- 2026/10/16 01:10 PHST- 2026/09/02 00:00 [received] PHST- 2026/09/25 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - nu18193245 [pii] AID - nutrients-18-03245 [pii] AID - 10.3390/nu18193245 [doi] PST - epublish SO - Nutrients. 2026 Oct 1;18(19):3245. doi: 10.3390/nu18193245. PMID- 42884691 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Oct 1 TI - Enteral Feeding During Therapeutic Hypothermia for Hypoxic-Ischemic Encephalopathy in Neonates: A Multicentre Study from Italy and Belgium. LID - 10.3390/nu18193240 [doi] LID - 3240 AB - Background: Enteral feeding during therapeutic hypothermia (TH) for hypoxic-ischemic encephalopathy (HIE) remains heterogeneous across centres because of concerns regarding feeding intolerance and the risk of necrotizing enterocolitis (NEC). Evidence regarding optimal feeding initiation and advancement remains limited. Methods: We performed a secondary analysis of a multicentre retrospective cohort of infants with HIE treated with TH at two tertiary neonatal intensive care units in Italy and Belgium between 2011 and 2024. We included survivors with complete nutritional data, aware that this restriction, adopted because feeding-related endpoints cannot be assessed in non-survivors, may introduce survivor bias. Feeding practices, enteral feeding progression, feeding tolerance, and gastrointestinal outcomes were evaluated. Results: Of 302 infants in the original cohort, 276 were included. Enteral feeding during TH was administered to 166 infants (60.1%). Enteral feeding volumes remained low during the first three days of life but progressively increased thereafter. Despite inter-center differences in feeding strategies (initiation and advancement), time to full enteral feeding (median 9 days; IQR 7-12) was comparable overall (Italy: median 9 days, IQR 7-12; Belgium: median 10 days, IQR 7-14; p = 0.323). Infants receiving enteral nutrition during TH were observed to achieve full enteral feeding earlier than those not fed during cooling (median 8.0 vs. 12.0 days, p < 0.001) and to have a shorter length of hospital stay (median 11.0 vs. 15.0 days, p < 0.001). Breastfeeding at discharge was also observed more frequently among infants who received enteral nutrition during TH (79.5% vs. 54.5%, p < 0.001). Feeding intolerance occurred in 47 infants (17.0%) and temporary feeding withdrawal in 31 (11.2%). Only three infants (1.1%) developed Bell stage IIA NEC, with no progression to more advanced disease or surgery. NEC was more frequent among infants with Sarnat stage III HIE than among those with stage I-II disease (8.3% vs. 0.4%, p = 0.022). Conclusions: Enteral feeding during TH was feasible, and gastrointestinal complications were uncommon. These findings support the feasibility of cautious enteral feeding during TH. The concentration of NEC events among infants with severe HIE, although based on only three cases, is hypothesis-generating and suggests that future studies should evaluate feeding strategies according to both neurological severity and physiological stability. Whether earlier initiation or faster advancement is beneficial in clinically stable infants cannot be determined from these observational data and should be addressed in prospective studies. FAU - De Rose, Domenico Umberto AU - De Rose DU AUID- ORCID: 0000-0002-9076-9838 AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Bersani, Iliana AU - Bersani I AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Salvatori, Guglielmo AU - Salvatori G AUID- ORCID: 0000-0001-8761-8732 AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Campi, Francesca AU - Campi F AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Martini, Ludovica AU - Martini L AUID- ORCID: 0000-0002-3090-5949 AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Maddaloni, Chiara AU - Maddaloni C AUID- ORCID: 0000-0002-4265-0939 AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Ronci, Sara AU - Ronci S AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Santisi, Alessandra AU - Santisi A AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Savarese, Immacolata AU - Savarese I AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Auriti, Cinzia AU - Auriti C AUID- ORCID: 0000-0001-9820-6557 AD - Faculty of Medicine and Surgery, Unicamillus, Saint Camillus International University of Health and Medical Sciences, 00131 Rome, Italy. FAU - Camacho Santamaria, Elena AU - Camacho Santamaria E AD - Division of Neonatology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 1200 Brussels, Belgium. FAU - De Groote, Anais AU - De Groote A AD - Division of Neonatology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 1200 Brussels, Belgium. FAU - Carkeek, Katherine AU - Carkeek K AD - Division of Neonatology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 1200 Brussels, Belgium. FAU - Iacona, Giulia AU - Iacona G AD - Faculty of Medicine, Imperial College, London SW7 2AZ, UK. FAU - Cilio, Maria Roberta AU - Cilio MR AD - Division of Child Neurology, Department of Pediatrics, Cliniques Universitaires Saint-Luc, Institute of Neuroscience (IoNS), Universite Catholique de Louvain, 1200 Brussels, Belgium. FAU - Ronchetti, Maria Paola AU - Ronchetti MP AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Braguglia, Annabella AU - Braguglia A AD - Neonatal Sub-Intensive Care Unit and Follow-Up, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Danhaive, Olivier AU - Danhaive O AD - Division of Neonatology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 1200 Brussels, Belgium. FAU - Dotta, Andrea AU - Dotta A AUID- ORCID: 0000-0002-1260-6427 AD - Neonatal Intensive Care Unit, "Bambino Gesu" Children's Hospital IRCCS, 00165 Rome, Italy. FAU - Piersigilli, Fiammetta AU - Piersigilli F AUID- ORCID: 0000-0002-6581-2822 AD - Division of Neonatology, Cliniques Universitaires Saint Luc, Universite Catholique de Louvain, 1200 Brussels, Belgium. LA - eng GR - Current Research funds/Ministero della Salute/ PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20261001 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Female MH - Humans MH - Infant, Newborn MH - Male MH - Belgium MH - *Enteral Nutrition/methods/adverse effects MH - Enterocolitis, Necrotizing/etiology/prevention & control MH - *Hypothermia, Induced/methods/adverse effects MH - *Hypoxia-Ischemia, Brain/therapy MH - Intensive Care Units, Neonatal MH - Italy MH - Retrospective Studies MH - Treatment Outcome PMC - PMC13666962 OTO - NOTNLM OT - breastfeeding OT - donor human milk OT - feeding tolerance OT - gastrointestinal outcomes OT - human milk OT - necrotizing enterocolitis OT - neonatal intensive care unit OT - neonatal nutrition OT - nutritional support OT - parenteral nutrition OT - perinatal asphyxia COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/01 CRDT- 2026/10/16 01:10 PHST- 2026/08/18 00:00 [received] PHST- 2026/09/25 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - nu18193240 [pii] AID - nutrients-18-03240 [pii] AID - 10.3390/nu18193240 [doi] PST - epublish SO - Nutrients. 2026 Oct 1;18(19):3240. doi: 10.3390/nu18193240. PMID- 42884683 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 30 TI - Quality Indicators for Evaluation of Neonatal Basic Care in Nutrition and Feeding: A Scoping Review and Modified Delphi Study. LID - 10.3390/nu18193230 [doi] LID - 3230 AB - Background/Objectives: Despite the clinical relevance of nutrition and feeding in neonatal intensive care, no consensus-based set of quality indicators currently exists to systematically evaluate basic nutritional care in hospitalised neonates. This study aimed to identify, agree through expert consensus and prioritise a structured set of nursing-sensitive quality indicators for this domain. Methods: A two-phase methodological study combined a Scoping Review (Joanna Briggs Institute methodology; prospectively registered on OSF; reported per PRISMA-ScR) and a two-round modified Delphi study based on the RAND/UCLA Appropriateness Method. Four databases (PubMed, Embase, Scopus, and Cochrane Library; 2020-2025) were searched, complemented by snowball and the grey literature. Twenty-seven candidate indicators synthesised inductively into eight domains were rated by 23 expert nurses across three dimensions (appropriateness, clinical validity, and feasibility) on a nine-point Likert scale. Results: Retention from Round 1 to Round 2 was 87% (n = 20). Twenty-two indicators (81.5%) were classified as appropriate and five (18.5%) as uncertain, in all cases because of feasibility. The overall median for appropriateness and clinical validity was 9.0 in both rounds. Feasibility showed greater variability, with an 18% mean IQR reduction after Round 2. Indicators reaching consensus were distributed across structure (n = 3, 13.6%), process (n = 16, 72.7%) and outcome (n = 3, 13.6%) dimensions. An exploratory post-hoc prioritisation analysis identified four implementation tiers; the five Tier 1 indicators ranked in the top five under every weighting scheme tested. Conclusions: This consensus-based set provides a structured basis for monitoring neonatal nutritional care quality and for reducing clinical variability. Validation by a broader interdisciplinary panel including families, and prospective testing in routine practice, are required before its use in clinical dashboards or benchmarking. FAU - Buck Sainz-Rozas, Pablo AU - Buck Sainz-Rozas P AD - Health Services Research Group, Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain. AD - Methodology of Biomedical Research and Public Health, Universitat Autonoma de Barcelona (UAB), 08193 Bellaterra, Spain. FAU - Osorio Sanchez, Dimelza AU - Osorio Sanchez D AD - Health Services Research Group, Vall d'Hebron Institut de Recerca (VHIR), 08035 Barcelona, Spain. AD - Methodology of Biomedical Research and Public Health, Universitat Autonoma de Barcelona (UAB), 08193 Bellaterra, Spain. AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Garcia Molina, Pablo AU - Garcia Molina P AUID- ORCID: 0000-0002-5900-6314 AD - Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain. AD - Department of Nursing, Universitat de Valencia, 46010 Valencia, Spain. FAU - Balaguer-Lopez, Evelin AU - Balaguer-Lopez E AUID- ORCID: 0000-0003-4204-3511 AD - Hospital Clinico Universitario de Valencia, 46010 Valencia, Spain. AD - Department of Nursing, Universitat de Valencia, 46010 Valencia, Spain. FAU - Alonso Fernandez, Sergio AU - Alonso Fernandez S AUID- ORCID: 0000-0001-6969-9380 AD - Fundamental and Clinical Nursing Department, Nursing Faculty, University of Barcelona (UB), 08907 Barcelona, Spain. AD - Nursing Research Group (GRIN), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Spain. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260930 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Delphi Technique MH - *Quality Indicators, Health Care MH - Infant, Newborn MH - Consensus MH - *Intensive Care, Neonatal/standards MH - *Infant Nutritional Physiological Phenomena PMC - PMC13666701 OTO - NOTNLM OT - Delphi method OT - RAND/UCLA OT - breastfeeding OT - neonatal nursing OT - neonatal nutrition OT - nursing-sensitive indicators OT - patient safety OT - quality indicators COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/30 CRDT- 2026/10/16 01:10 PHST- 2026/08/14 00:00 [received] PHST- 2026/09/25 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - nu18193230 [pii] AID - nutrients-18-03230 [pii] AID - 10.3390/nu18193230 [doi] PST - epublish SO - Nutrients. 2026 Sep 30;18(19):3230. doi: 10.3390/nu18193230. PMID- 42884672 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 29 TI - Beyond Self-Reported Adherence and Serology: Stool Gluten Immunogenic Peptides Detection to Assess Gluten Exposure in Children with Celiac Disease on a Gluten-Free Diet. LID - 10.3390/nu18193221 [doi] LID - 3221 AB - Background/Objectives: A lifelong gluten-free diet (GFD) is the only treatment for celiac disease (CD). However, current methods for monitoring GFD adherence do not accurately assess gluten exposure. Stool detection of gluten immunogenic peptides (GIP) may provide an objective tool for detecting recent gluten exposure. The aim of this study was to evaluate stool GIP detection, compared with serology and the validated Biagi dietary questionnaire, for monitoring GFD adherence in children with CD. Methods: In this prospective multicenter study, pediatric patients with CD on a GFD for at least 1 year were enrolled. Serum and stool samples were collected on the same day to assess serum anti-transglutaminase (TTG) and anti-endomysium (EMA) antibodies and stool GIP. Patients also completed the Biagi dietary questionnaire. Results: Forty-one pediatric patients with CD on a GFD for a median of 6.5 years were enrolled. Serum TTG and/or EMA were positive in 8/41 patients (19.5%), Biagi questionnaire identified 8/41 patients (19.5%) as non-adherent, whereas stool GIP was positive in 17/41 (41.5%). Combining serology with the dietary questionnaire increased the proportion of non-adherent patients to 34%. Adding stool GIP detection increased this proportion to 51% and 46% when combined with serology or the dietary questionnaire, respectively. Overall, 23/41 patients (56%) showed evidence of gluten exposure when positivity in at least one of the three methods was considered. Conclusions: A high rate of recent gluten exposure was detected in children with CD on a long-term GFD. Stool GIP detection may provide complementary information to conventional methods for monitoring GFD adherence and may help identify patients requiring further dietary assessment or intervention. FAU - Ziberna, Fabiana AU - Ziberna F AUID- ORCID: 0000-0002-9748-902X AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - Fontana, Giorgia AU - Fontana G AUID- ORCID: 0000-0001-7268-4104 AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - Zanchi, Chiara AU - Zanchi C AUID- ORCID: 0000-0001-8513-1963 AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - Bobbo, Marco AU - Bobbo M AD - Department of Pediatrics, University of Trieste, 34127 Trieste, Italy. FAU - Spinelli, Elena AU - Spinelli E AUID- ORCID: 0009-0008-6102-2250 AD - Department of Medical and Surgical Sciences, University of Trieste, 34127 Trieste, Italy. FAU - Grimaldi, Maria Cristina AU - Grimaldi MC AUID- ORCID: 0000-0002-4646-0032 AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - Tizi, Fatima AU - Tizi F AUID- ORCID: 0009-0009-8001-3314 AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - Di Leo, Grazia AU - Di Leo G AUID- ORCID: 0000-0002-6313-4482 AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - Martelossi, Stefano AU - Martelossi S AD - Ca' Foncello Hospital, 31100 Treviso, Italy. FAU - Not, Tarcisio AU - Not T AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. FAU - De Leo, Luigina AU - De Leo L AUID- ORCID: 0000-0003-4013-1630 AD - Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Via dell'Istria 65/1, 34137 Trieste, Italy. LA - eng GR - RC11/19/Ministry of Health/ PT - Journal Article PT - Multicenter Study DEP - 20260929 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 8002-80-0 (Glutens) RN - 0 (Peptides) RN - 0 (Autoantibodies) SB - IM MH - Humans MH - *Celiac Disease/diet therapy/immunology/blood MH - *Diet, Gluten-Free MH - Child MH - Female MH - *Glutens/immunology/analysis MH - *Feces/chemistry MH - Male MH - Prospective Studies MH - *Patient Compliance MH - Adolescent MH - Child, Preschool MH - *Peptides/analysis/immunology MH - Self Report MH - Surveys and Questionnaires MH - Autoantibodies/blood PMC - PMC13667095 OTO - NOTNLM OT - Biagi questionnaire OT - celiac disease OT - gluten immunogenic peptides OT - gluten-free diet COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/29 CRDT- 2026/10/16 01:10 PHST- 2026/09/08 00:00 [received] PHST- 2026/09/28 00:00 [revised] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - nu18193221 [pii] AID - nutrients-18-03221 [pii] AID - 10.3390/nu18193221 [doi] PST - epublish SO - Nutrients. 2026 Sep 29;18(19):3221. doi: 10.3390/nu18193221. PMID- 42884631 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 26 TI - Dietary Management of IgE-Mediated and Non-IgE-Mediated Food Allergies: A Systematic Review of Current Evidence and Clinical Implications. LID - 10.3390/nu18193180 [doi] LID - 3180 AB - BACKGROUND: Food allergy is an increasing global health problem associated with substantial clinical, nutritional, and psychosocial burden. METHODS: This systematic review was conducted according to the PRISMA 2020 Statement. PubMed/MEDLINE and Scopus were systematically searched for studies published between January 2016 and December 2025. A total of 218 records were identified, of which 180 were screened after duplicate removal; 14 studies met the predefined eligibility criteria and were included in the qualitative synthesis. Methodological quality was assessed using validated appraisal tools according to study design, and findings were synthesized narratively following the SWIM guideline. RESULTS: Avoidance of confirmed culprit foods remains a central component of food allergy management, although prolonged or unnecessarily restrictive elimination may adversely affect dietary diversity, nutritional adequacy, growth, and quality of life, particularly in children and patients with multiple food allergies. Randomized controlled trials and systematic reviews support early allergen introduction for prevention of IgE-mediated food allergies and oral immunotherapy as an active treatment option in selected patients with IgE-mediated food allergies, although treatment-related adverse events remain an important consideration. In contrast, evidence supporting several dietary management strategies for non-IgE-mediated food allergies is more frequently derived from observational studies and evidence-based recommendations, highlighting important gaps in the current evidence base. CONCLUSIONS: Current evidence supports individualized dietary management based on regular reassessment, nutritional monitoring, supervised food reintroduction when clinically appropriate, and multidisciplinary care. The evidence supporting different dietary strategies remains heterogeneous, particularly for non-IgE-mediated food allergies, emphasizing the need for further high-quality research. FAU - Gratacos Gomez, Alejandro Raul AU - Gratacos Gomez AR AUID- ORCID: 0000-0002-9456-5760 AD - Servicio de Endocrinologia y Nutricion del Hospital Universitario de Toledo, 45071 Toledo, Spain. FAU - Iniesta Tejera, Esther AU - Iniesta Tejera E AD - Servicio de Alergologia del Hospital General Universitario de Ciudad Real, 13005 Ciudad Real, Spain. FAU - Bas Bellver, Laura AU - Bas Bellver L AD - Servicio de Alergologia del Hospital General Universitario de Ciudad Real, 13005 Ciudad Real, Spain. FAU - Pablo, Sergio Serrano de AU - Pablo SS AD - Servicio de Alergologia del Hospital General Universitario de Ciudad Real, 13005 Ciudad Real, Spain. FAU - Clar Castello, Miriam AU - Clar Castello M AD - Servicio de Alergologia del Hospital General Universitario de Ciudad Real, 13005 Ciudad Real, Spain. FAU - Gomez Torrijos, Elisa AU - Gomez Torrijos E AUID- ORCID: 0000-0002-4532-2498 AD - Servicio de Alergologia del Hospital General Universitario de Ciudad Real, 13005 Ciudad Real, Spain. LA - eng PT - Journal Article PT - Review PT - Systematic Review DEP - 20260926 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 37341-29-0 (Immunoglobulin E) RN - 0 (Allergens) SB - IM MH - Humans MH - *Food Hypersensitivity/immunology/diet therapy MH - *Immunoglobulin E/immunology MH - Child MH - Elimination Diets MH - Child, Preschool MH - Quality of Life MH - Allergens/immunology MH - Female MH - Male PMC - PMC13666680 OTO - NOTNLM OT - IgE-mediated food allergy OT - dietary management OT - elimination diet OT - food allergy OT - non-IgE-mediated food allergy OT - nutrition OT - oral immunotherapy OT - systematic review COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/26 CRDT- 2026/10/16 01:10 PHST- 2026/07/10 00:00 [received] PHST- 2026/09/23 00:00 [revised] PHST- 2026/09/24 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/26 00:00 [pmc-release] AID - nu18193180 [pii] AID - nutrients-18-03180 [pii] AID - 10.3390/nu18193180 [doi] PST - epublish SO - Nutrients. 2026 Sep 26;18(19):3180. doi: 10.3390/nu18193180. PMID- 42884617 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 25 TI - Evaluation of a Wearable Hydration Monitor for Estimating Sweat Loss and Hydration Status in Collegiate Athletes: A Pilot Study. LID - 10.3390/nu18193166 [doi] LID - 3166 AB - BACKGROUND/OBJECTIVE: Instantaneous, accurate assessment of hydration and sweat loss has potential to optimize athlete performance and reduce risks associated with excessive exercise-related fluid loss. Reusable wearable hydration monitors, such as hDrop monitors, are an emerging non-invasive, quick, and easy to use alternative to existing methods. PURPOSE: To assess the accuracy of the hDrop wearable sweat monitors for estimating sweat loss and hydration status compared to established field-based measures, including body mass change and urine indices. METHODS: Division I male collegiate soccer athletes contributed repeated training-session observations (38 total observations; 18 complete observations for sweat-loss analyses and 36 for hydration-score-USG analyses). They completed training sessions during which pre- and post-exercise body mass, fluid intake, urine output, and urine samples were collected. Sweat loss was calculated using changes in body mass adjusted for fluid balance. hDrop-derived estimates of sweat loss and hydration status were compared to criterion measures using mean bias, percent of criterion, mean absolute percent error (MAPE), repeated-measures Bland-Altman analysis, and generalized estimating equations accounting for observations clustered within athletes. Associations between hydration scores and urine-based markers were assessed using generalized estimating equations accounting for observations clustered within athletes. RESULTS: The hDrop generated a sweat-loss estimate for 18 of 38 training-session observations (47.4%). Repeated-measures mean bias for sweat loss was -0.423 L (95% CI -1.106 to 0.259 L). The hDrop estimates averaged 106.2 +/- 64.8% of criterion while MAPE was 50.3%, reflecting large individual error. In the repeated-measures analysis, criterion-measured sweat loss was positively associated with hDrop-estimated sweat loss (B = 0.204, 95% CI 0.018 to 0.391, p = 0.032). Significant proportional bias was present (slope = -0.790, 95% CI -1.438 to -0.143, p = 0.020), indicating greater underestimation at higher sweat-loss values. In repeated-measures GEE analyses, USG was not significantly associated with the hDrop hydration score either before practice (B = -407.9, 95% CI -1008.7 to 192.8, p = 0.183) or after practice (B = -135.0, 95% CI -803.8 to 533.7, p = 0.692). CONCLUSIONS: The hDrop generated sweat-loss estimates in fewer than half of training-session observations and demonstrated substantial individual-level error and significant proportional bias when estimates were available. Although the instantaneous hydration score decreased following exercise, its lack of association with USG leaves its physiological meaning and criterion validity uncertain. These findings do not support use of the hDrop as an interchangeable substitute for established methods of individualized sweat-loss or hydration assessment. FAU - Snyder, Jill McCann AU - Snyder JM AUID- ORCID: 0009-0000-4031-3763 AD - Department of Nutrition and Dietetics, Brooks College of Health, University of North Florida, Jacksonville, FL 32224, USA. FAU - Toth, Lindsay AU - Toth L AUID- ORCID: 0000-0001-5856-2012 AD - Department of Clinical and Applied Movement Sciences, Brooks College of Health, University of North Florida, Jacksonville, FL 32224, USA. FAU - Aguero, Elysse AU - Aguero E AD - Department of Nutrition and Dietetics, Brooks College of Health, University of North Florida, Jacksonville, FL 32224, USA. FAU - Brennan, Colleen AU - Brennan C AD - Department of Nutrition and Dietetics, Brooks College of Health, University of North Florida, Jacksonville, FL 32224, USA. FAU - Duarte, Kassandra AU - Duarte K AD - Department of Nutrition and Dietetics, Brooks College of Health, University of North Florida, Jacksonville, FL 32224, USA. LA - eng GR - Brooks College of Health Pilot Research Grant/ PT - Journal Article DEP - 20260925 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Pilot Projects MH - *Wearable Electronic Devices MH - *Athletes MH - *Sweating/physiology MH - Young Adult MH - *Organism Hydration Status MH - *Dehydration/diagnosis MH - Water-Electrolyte Balance MH - Sweat MH - Monitoring, Physiologic/instrumentation MH - Adolescent MH - Drinking MH - Reproducibility of Results MH - Soccer MH - Exercise/physiology PMC - PMC13666982 OTO - NOTNLM OT - hydration assessment OT - sweat loss OT - validity COIS- hDrop Technologies Inc. donated the wearable monitors used in this study. The company had no role in the study design; collection, analysis, or interpretation of the data; preparation of the manuscript; or decision to submit the manuscript for publication. hDrop Technologies Inc. did not have access to the raw study data before manuscript preparation or submission. The authors declare no other conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/25 CRDT- 2026/10/16 01:10 PHST- 2026/08/04 00:00 [received] PHST- 2026/09/19 00:00 [revised] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - nu18193166 [pii] AID - nutrients-18-03166 [pii] AID - 10.3390/nu18193166 [doi] PST - epublish SO - Nutrients. 2026 Sep 25;18(19):3166. doi: 10.3390/nu18193166. PMID- 42884610 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 25 TI - Nutritional Accuracy and Clinical Applicability of Large Language Model-Generated Therapeutic Diet Plans for Phenylketonuria: A Comparative Simulation Study. LID - 10.3390/nu18193158 [doi] LID - 3158 AB - Background: Large language models (LLMs) are increasingly used to generate nutrition-related recommendations, but their reliability for therapeutic diets requiring precise nutrient control remains uncertain. This study evaluated AI-generated one-day diet plans for standardized simulated cases of classical phenylketonuria (PKU). Methods: Eight standardized simulated cases representing infancy, adolescence, adulthood, and maternal PKU were evaluated. Between 8 and 10 February 2026, ChatGPT-5.2, Claude 4.5, and Gemini 3 were each used through their standard consumer-facing chat interfaces to generate one diet plan per case under two prompting conditions, yielding 48 plans. Nutrient composition was independently recalculated using BIAYS, and three blinded pediatric metabolic dietitians evaluated the plans using a structured 25-item checklist. Results: Across all 48 plans, phenylalanine provision calculated using BIAYS was below the case-specific prescription in 36 plans (75.0%). After Holm correction, none of the 12 paired AI-reported versus BIAYS-calculated nutrient comparisons remained statistically significant, while plan-level error metrics demonstrated substantial variability for several nutrients. Overall expert scores did not differ among models, whereas clinically specified structured prompts received higher expert ratings than limited-information zero-shot prompts. Inter-rater reliability was modest at the diet-plan level. Conclusions: AI-generated PKU diet plans may incorporate core dietary principles, but numerical plausibility does not ensure agreement with independent nutrient calculations or adherence to individualized clinical prescriptions. Independent nutrient verification and specialist metabolic-dietitian review remain necessary. Because only one output was generated for each case-model-prompt combination, the findings characterize the 48 evaluated outputs rather than within-model reproducibility. FAU - Kulu, Bahar AU - Kulu B AD - Division of Inherited Metabolic Disorders, University of Health Sciences, Tepecik Training and Research Hospital, Izmir 35170, Turkiye. FAU - Suzen, Banu AU - Suzen B AUID- ORCID: 0000-0002-5975-5868 AD - Department of Nutrition and Dietetics, School of Health Sciences, Cappadocia University, Nevsehir 50420, Turkiye. FAU - Mintas, Nuriye Ece AU - Mintas NE AUID- ORCID: 0000-0002-0033-6861 AD - Division of Inherited Metabolic Disorders, Mugla Training and Research Hospital, Mugla 48000, Turkiye. FAU - Sahin Uyar, Sibel Burcak AU - Sahin Uyar SB AD - Division of Inherited Metabolic Disorders, Izmir City Hospital, Izmir 35530, Turkiye. FAU - Ozcan, Esra AU - Ozcan E AUID- ORCID: 0009-0009-9393-143X AD - Department of Nutrition and Dietetics, Izmir City Hospital, Izmir 35530, Turkiye. FAU - Durgun, Fulya AU - Durgun F AUID- ORCID: 0009-0005-1365-2475 AD - Department of Nutrition and Dietetics, Tepecik Training and Research Hospital, Izmir 35180, Turkiye. FAU - Tatlidil, Neslihan Buse AU - Tatlidil NB AUID- ORCID: 0009-0002-0059-178X AD - Department of Nutrition and Dietetics, Tepecik Training and Research Hospital, Izmir 35180, Turkiye. FAU - Arslan, Nur AU - Arslan N AD - Division of Inherited Metabolic Disorders, Faculty of Medicine, Dokuz Eylul University, Izmir 35340, Turkiye. AD - Izmir Biomedicine and Genome Center (IBG), Izmir 35340, Turkiye. FAU - Hanci, Volkan AU - Hanci V AUID- ORCID: 0000-0002-2227-194X AD - Department of Anesthesiology and Reanimation, Division of Intensive Care, Faculty of Medicine, Dokuz Eylul University, Izmir 35340, Turkiye. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260925 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 47E5O17Y3R (Phenylalanine) SB - IM MH - *Phenylketonurias/diet therapy MH - Humans MH - *Large Language Models MH - Reproducibility of Results MH - Female MH - Adolescent MH - Infant MH - Child MH - Adult MH - Computer Simulation MH - Phenylalanine/blood MH - *Diet Therapy/methods PMC - PMC13667255 OTO - NOTNLM OT - artificial intelligence OT - clinical nutrition OT - diet planning OT - large language models OT - phenylketonuria OT - therapeutic diet COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/25 CRDT- 2026/10/16 01:10 PHST- 2026/08/25 00:00 [received] PHST- 2026/09/20 00:00 [revised] PHST- 2026/09/24 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - nu18193158 [pii] AID - nutrients-18-03158 [pii] AID - 10.3390/nu18193158 [doi] PST - epublish SO - Nutrients. 2026 Sep 25;18(19):3158. doi: 10.3390/nu18193158. PMID- 42884600 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 24 TI - Too Wordy, Too Long and Too Cluttered: User Acceptance Testing, Co-Design, and Early Beta Testing to Adapt the Daily Health Coach for Young Australian Women. LID - 10.3390/nu18193150 [doi] LID - 3150 AB - Background/Objectives: The Daily Health Coach (DHC) is a 12-week Instagram-based nutrition and wellbeing programme originally co-designed and tested in New Zealand to deliver evidence-based, weight-neutral content on nutrition, movement, body image, and wellbeing. This formative, mixed-methods adaptation study examined the acceptability of DHC New Zealand content for young Australian women and identified refinements to improve relevance, engagement, and safety before effectiveness evaluation. Methods: Using the CODES framework, we conducted three adaptation phases: user acceptance testing, co-design workshops, and early beta testing. Following data-quality screening, 291 young women aged 18-24 years who completed all 12 survey sections were included in Phase 1. Participants rated 84 Instagram-style posts for understanding and usefulness and provided open-ended feedback. Twelve young women participated in co-design workshops, and seven adapted artefacts were beta-tested with eight target users using cognitive walkthrough and think-aloud methods. Quantitative findings were examined descriptively, with sensitivity analyses undertaken to assess robustness to response-quality and sample-composition concerns. Results: Participant-level mean understanding was 3.99 +/- 0.75/5, usefulness was 3.89 +/- 0.74/5, and the combined score was 7.87 +/- 1.47/10. Post-level combined means ranged from 7.66 to 8.11/10; all 84 posts met a >/=7.5 descriptive benchmark adapted from prior message-testing work, although this is an interpretive aid rather than a validated cut-off. Sensitivity analyses showed a similar overall pattern: ratings were higher in a higher-confidence response-quality sample (n = 199; 8.34 +/- 1.20/10), while four posts fell marginally below 7.5 when analysis was restricted to participants not reporting Aboriginal and/or Torres Strait Islander identity (n = 101). Qualitative feedback identified six refinement areas: content features, engagement strategies, clarity, educational accuracy, relevance, and miscellaneous concerns. Co-design and beta testing generated four adaptation priorities: tone, design, engagement, and understanding. Conclusions: DHC New Zealand content was generally well understood and favourably rated but required targeted refinement for the Australian context. Findings provide formative guidance for final adaptation and subsequent effectiveness evaluation. FAU - Roy, Rajshri AU - Roy R AUID- ORCID: 0000-0002-7939-1790 AD - Nutrition and Dietetics, Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia. AD - Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia. FAU - Hamilton, Isabella AU - Hamilton I AD - Nutrition and Dietetics, Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia. FAU - Khan, Demera AU - Khan D AD - Nutrition and Dietetics, Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia. FAU - Issa, Mariah AU - Issa M AUID- ORCID: 0009-0001-2512-9332 AD - Nutrition and Dietetics, Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia. AD - Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia. AD - School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia. FAU - Alami, Jasmin AU - Alami J AUID- ORCID: 0009-0002-5323-724X AD - TUM School of Life Sciences, Technical University of Munich, 85354 Freising, Germany. FAU - Malloy, Jessica A AU - Malloy JA AUID- ORCID: 0000-0002-5569-1019 AD - Nutrition and Dietetics, Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2050, Australia. LA - eng GR - The University of Sydney/ PT - Journal Article DEP - 20260924 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adolescent MH - Australia MH - Young Adult MH - New Zealand MH - *Health Promotion/methods MH - Surveys and Questionnaires MH - *Social Media PMC - PMC13667190 OTO - NOTNLM OT - body image OT - co-design OT - cultural adaptation OT - digital health OT - health promotion OT - nutrition OT - social media OT - usability testing OT - user acceptance testing OT - young women COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/24 CRDT- 2026/10/16 01:10 PHST- 2026/07/22 00:00 [received] PHST- 2026/09/22 00:00 [revised] PHST- 2026/09/22 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/24 00:00 [pmc-release] AID - nu18193150 [pii] AID - nutrients-18-03150 [pii] AID - 10.3390/nu18193150 [doi] PST - epublish SO - Nutrients. 2026 Sep 24;18(19):3150. doi: 10.3390/nu18193150. PMID- 42884589 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 23 TI - The Gut-Skin Axis in Pediatric Atopic Dermatitis: Nutritional Modulation, Microbiome Interactions, and Emerging Precision Approaches. LID - 10.3390/nu18193138 [doi] LID - 3138 AB - BACKGROUND/OBJECTIVES: Pediatric atopic dermatitis (AD) is a barrier-driven inflammatory skin disease with systemic immune and microbial correlates. The gut-skin axis offers a biologically plausible framework through which early-life nutrition, gut microbial metabolism, intestinal barrier function, and immune maturation may influence disease risk and expression, but much of the supporting evidence remains associative. This narrative review asks which nutritional strategies are supported by clinical evidence in children with AD, which remain investigational, and how far the field is from precision nutrition. METHODS: PubMed/MEDLINE, Scopus, and Web of Science were searched up to 31 July 2026; guidelines, systematic reviews, randomized trials, birth cohorts, and mechanistic studies with pediatric relevance were prioritized and appraised narratively. RESULTS: Breastfeeding when possible, dietary diversity during complementary feeding, avoidance of unnecessary elimination diets, correction of documented nutritional deficiencies, and management of confirmed food allergy are supported by current guidance. Probiotics and synbiotics lower SCORAD in meta-analyses, but the pooled effect is small, heterogeneous, and below the minimal clinically important difference, so they are best described as an optional adjunct rather than a recommended treatment; Mediterranean-style or high-fiber dietary patterns are backed mainly by observational data. Microbiome profiling, metabolomics, multi-omics endotyping, and artificial intelligence remain research tools without validated predictive value for dietary responses. CONCLUSIONS: Nutrition is an adjunct to, not a substitute for, established topical and systemic therapy in pediatric AD. Precision nutrition is a promising research direction rather than an established component of routine care, and its clinical value will depend on standardized biomarkers and well-designed longitudinal and interventional studies. FAU - Miulescu, Raluca-Gabriela AU - Miulescu RG AD - Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania. AD - Saint Constantin Hospital, 500388 Brasov, Romania. FAU - Costescu, Mihnea AU - Costescu M AUID- ORCID: 0000-0002-3678-7584 AD - Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania. FAU - Marin, Ruxandra-Cristina AU - Marin RC AUID- ORCID: 0000-0002-3182-1683 AD - Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania. FAU - Musetescu, Alina AU - Musetescu A AD - Department of Dermatology, "Dr. Victor Babes" Clinical Hospital of Infectious and Tropical Diseases, 030303 Bucharest, Romania. AD - Department of Dermatology, "Titu Maiorescu" University, 031593 Bucharest, Romania. FAU - Muntean, Calin AU - Muntean C AUID- ORCID: 0000-0002-0497-0405 AD - Department III Functional Science, Discipline of Medical Informatics and Biostatistics, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania. FAU - Rosca, Ioana AU - Rosca I AUID- ORCID: 0009-0002-4629-5820 AD - Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania. AD - Pediatrics Department, National Institute for Mother and Child Health "Alessandrescu-Rusescu", 20382 Bucharest, Romania. FAU - Adam, Iris-Iuliana AU - Adam II AD - Saint Constantin Hospital, 500388 Brasov, Romania. FAU - Ilici, Alina AU - Ilici A AD - Adeomed Clinic, 061344 Bucharest, Romania. FAU - Coman, Oana Andreia AU - Coman OA AD - Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila", 020021 Bucharest, Romania. LA - eng PT - Journal Article PT - Review DEP - 20260923 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - *Gastrointestinal Microbiome/physiology MH - *Skin/microbiology MH - *Dermatitis, Atopic/complications/microbiology/therapy MH - Intestinal Barrier Function MH - *Child Nutritional Physiological Phenomena/physiology MH - *Precision Medicine/methods MH - Probiotics/administration & dosage MH - Diet MH - Dysbiosis/complications/microbiology/therapy MH - Humans MH - Child PMC - PMC13667208 OTO - NOTNLM OT - biomarkers OT - gut microbiome OT - gut-skin axis OT - microbial metabolites OT - nutrition OT - pediatric atopic dermatitis OT - precision nutrition OT - probiotics COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/23 CRDT- 2026/10/16 01:10 PHST- 2026/08/23 00:00 [received] PHST- 2026/09/17 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - nu18193138 [pii] AID - nutrients-18-03138 [pii] AID - 10.3390/nu18193138 [doi] PST - epublish SO - Nutrients. 2026 Sep 23;18(19):3138. doi: 10.3390/nu18193138. PMID- 42884588 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 23 TI - Host-Microbiota Interactions in Adolescents with Severe Anorexia Nervosa: Linking Gut Dysbiosis, Intestinal Barrier Function and Microbial Metabolism. LID - 10.3390/nu18193136 [doi] LID - 3136 AB - BACKGROUND: Anorexia nervosa (AN) is increasingly recognized as a multisystem disorder involving complex host-microbiota interactions, yet prospective pediatric studies with a comprehensive, longitudinal characterization of host-microbiota interactions remain scarce. METHODS: In this prospective longitudinal study, 26 adolescents with severe AN were evaluated at hospital admission (T0), after one month (T1), and after three months of inpatient nutritional rehabilitation (T2). Gut microbiota composition was assessed by 16S rRNA sequencing and compared with healthy controls (HC) at the baseline; predicted functional profiling was performed using PICRUSt2. Serum and urinary biomarkers of intestinal barrier integrity and microbial metabolism, routine clinical and biochemical parameters, and psychometric scores (CDI-2, MASC-2) were evaluated longitudinally using linear mixed-effects models. RESULTS: At the baseline, adolescents with AN showed reduced bacterial richness compared with healthy controls, with significantly lower Chao1 diversity (p = 0.00013), whereas the Shannon and Simpson indices did not differ significantly (p = 0.54 and p = 0.27, respectively). Microbial community composition differed significantly between groups based on Bray-Curtis (R(2) = 0.0724, FDR-adjusted p = 0.001) and unweighted UniFrac (R(2) = 0.0540, FDR-adjusted p = 0.001) distances. LEfSe identified 19 differentially abundant taxa; among the strongest discriminators, Blautia_A_141781, Romboutsia_B, and Clostridium_T were enriched in AN, whereas Akkermansia, Phocaeicola_A_858004, and Bacteroides_H were enriched in the healthy controls. Nutritional rehabilitation was associated with partial microbiota remodeling, alongside significant improvements in BMI and heart rate. Several host-derived biomarkers, including urinary indican, serotonin, nitric oxide, and serum occludin, changed significantly over time, whereas bile acids, short-chain fatty acids, IgA, lipopolysaccharide, and haptoglobin remained stable. CONCLUSIONS: Gut microbiota and host-derived biomarkers evolve dynamically during nutritional rehabilitation in adolescents with severe AN, supporting their potential role as complementary tools for monitoring biological recovery. FAU - Gargiullo, Livia AU - Gargiullo L AUID- ORCID: 0000-0003-0316-6359 AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Del Chierico, Federica AU - Del Chierico F AUID- ORCID: 0000-0002-4204-4736 AD - Unit of Microbiome, Bambino Gesu Children's Hospital, IRCCS, 00146 Rome, Italy. FAU - Marchili, Maria Rosaria AU - Marchili MR AUID- ORCID: 0000-0002-6787-8198 AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Irrera, Mariangela AU - Irrera M AUID- ORCID: 0009-0002-3274-9756 AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Pretelli, Italo AU - Pretelli I AD - Anorexia and Eating Disorders Unit, Child and Adolescent Psychiatry, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Scanu, Matteo AU - Scanu M AUID- ORCID: 0000-0001-6266-2884 AD - Unit of Microbiome, Bambino Gesu Children's Hospital, IRCCS, 00146 Rome, Italy. FAU - Toto, Francesca AU - Toto F AD - Unit of Microbiome, Bambino Gesu Children's Hospital, IRCCS, 00146 Rome, Italy. FAU - Grandin, Annalisa AU - Grandin A AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Marotta, Rosaria AU - Marotta R AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Mascolo, Cristina AU - Mascolo C AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Cirillo, Flavia AU - Cirillo F AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Colistra, Valentina AU - Colistra V AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Ricci, Ludovica AU - Ricci L AD - Pediatrics Residency Program, Department of Pediatrics, University of Rome Tor Vergata, 00133 Rome, Italy. FAU - Zanna, Valeria AU - Zanna V AD - Anorexia and Eating Disorders Unit, Child and Adolescent Psychiatry, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. FAU - Putignani, Lorenza AU - Putignani L AUID- ORCID: 0000-0003-0134-2830 AD - Department of Life Sciences, Health and Health Professions, Link Campus University, 00165 Rome, Italy. AD - Unit of Microbiomics and Unit of Microbiome, Bambino Gesu Children's Hospital, IRCCS, 00146 Rome, Italy. FAU - Villani, Alberto AU - Villani A AUID- ORCID: 0000-0002-9120-0424 AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, Bambino Gesu Children's Hospital, IRCCS, 00165 Rome, Italy. AD - Systems Medicine Departments, University of Rome Tor Vergata, 00133 Rome, Italy. LA - eng GR - RC2025_IMMUNO_GARGIULLO, RC2025_INNOV_DELCHIERICO/Ministry of Health/ PT - Journal Article DEP - 20260923 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) RN - 0 (RNA, Ribosomal, 16S) SB - IM MH - Humans MH - *Anorexia Nervosa/microbiology MH - Adolescent MH - Female MH - Intestinal Barrier Function MH - *Dysbiosis/microbiology MH - Prospective Studies MH - *Gastrointestinal Microbiome/physiology MH - Longitudinal Studies MH - Biomarkers/blood/urine MH - RNA, Ribosomal, 16S MH - Bacteria/classification/metabolism MH - Male PMC - PMC13666687 OTO - NOTNLM OT - anorexia nervosa OT - biomarkers OT - gut microbiota OT - gut-brain axis OT - intestinal permeability OT - nutritional rehabilitation COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/23 CRDT- 2026/10/16 01:10 PHST- 2026/08/13 00:00 [received] PHST- 2026/09/17 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - nu18193136 [pii] AID - nutrients-18-03136 [pii] AID - 10.3390/nu18193136 [doi] PST - epublish SO - Nutrients. 2026 Sep 23;18(19):3136. doi: 10.3390/nu18193136. PMID- 42884577 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 19 DP - 2026 Sep 23 TI - Dietary and Fluid-Intake Habits in Patients with Various Types of Urinary Incontinence: A Preliminary Study. LID - 10.3390/nu18193127 [doi] LID - 3127 AB - Background/Objectives: Urinary incontinence (UI) is common in women, particularly during and after the menopausal transition, and may both influence and be influenced by dietary and fluid-intake behaviours. This exploratory study described self-reported dietary and fluid-intake habits in women with different UI subtypes and explored their associations with pelvic floor symptom burden and self-reported fluid restriction. Energy and nutrient intake was not quantified. Methods: This exploratory, cross-sectional, single-centre study included 87 women aged 18-84 years with stress (SUI; n = 23), urgency (UUI; n = 21), or mixed (MUI; n = 43) UI, who reported UI at least weekly. Participants completed a custom dietary and fluid-intake questionnaire, the Incontinence Quality of Life Questionnaire (I-QOL), and the Pelvic Floor Distress Inventory-20 (PFDI-20). Associations were assessed using rank correlations and proportional-odds ordinal logistic regression, with Benjamini-Hochberg correction used to address multiplicity in exploratory item-level analyses. Results: No individual diet-PFDI association remained statistically significant after Benjamini-Hochberg correction across the complete 100-test matrix. In the adjusted model, an urgency component was associated with greater self-reported fluid restriction (adjusted cumulative OR = 2.92; 95% CI, 1.18-7.20), whereas each 10-year increase in age was associated with lower odds of greater restriction (adjusted cumulative OR = 0.68; 95% CI, 0.51-0.92). Conclusions: Greater self-reported fluid restriction was independently associated with an urgency component and with younger age, whereas no individual dietary or fluid-intake item remained statistically significant after correction for multiple comparisons. Given the potential risk of the practice, these findings support asking women with urgency symptoms about fluid restriction during clinical consultations. Prospective studies using a validated quantitative dietary instrument are needed to determine whether dietary and fluid-intake habits affect pelvic floor symptom burden. FAU - Piatek, Aleksandra AU - Piatek A AUID- ORCID: 0000-0002-5887-817X AD - Department of Gynecology, Independent Public Health Care Center of the Ministry of the Interior and Administration in Wroclaw, 50-233 Wroclaw, Poland. FAU - Kolodynska, Gabriela AU - Kolodynska G AUID- ORCID: 0000-0001-7921-7058 AD - Faculty of Physiotherapy, Wroclaw University of Health and Sport Sciences, 51-612 Wroclaw, Poland. FAU - Nowak, Krzysztof AU - Nowak K AUID- ORCID: 0000-0002-2230-9012 AD - Department of Gynecology, Independent Public Health Care Center of the Ministry of the Interior and Administration in Wroclaw, 50-233 Wroclaw, Poland. FAU - Drapala, Jaroslaw AU - Drapala J AUID- ORCID: 0000-0002-7251-9595 AD - Faculty of Information and Communication Technology, Wroclaw University of Science and Technology, 50-370 Wroclaw, Poland. FAU - Fink-Lwow, Felicja AU - Fink-Lwow F AUID- ORCID: 0000-0002-4323-7134 AD - Faculty of Physiotherapy, Wroclaw University of Health and Sport Sciences, 51-612 Wroclaw, Poland. FAU - Andrzejewski, Waldemar AU - Andrzejewski W AUID- ORCID: 0000-0002-0010-3021 AD - Faculty of Physiotherapy, Wroclaw University of Health and Sport Sciences, 51-612 Wroclaw, Poland. FAU - Zalewski, Maciej AU - Zalewski M AUID- ORCID: 0000-0002-0924-6870 AD - Department of Gynecology, Independent Public Health Care Center of the Ministry of the Interior and Administration in Wroclaw, 50-233 Wroclaw, Poland. LA - eng PT - Journal Article DEP - 20260923 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Middle Aged MH - Aged MH - Adult MH - Cross-Sectional Studies MH - Aged, 80 and over MH - Adolescent MH - Young Adult MH - Quality of Life MH - *Diet MH - *Urinary Incontinence/physiopathology MH - Surveys and Questionnaires MH - *Feeding Behavior MH - *Drinking MH - *Drinking Behavior MH - Urinary Incontinence, Stress PMC - PMC13666888 OTO - NOTNLM OT - PFDI-20 OT - dietary habits OT - fluid intake OT - nutrition OT - overactive bladder OT - urinary incontinence COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/23 CRDT- 2026/10/16 01:10 PHST- 2026/07/20 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:10 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - nu18193127 [pii] AID - nutrients-18-03127 [pii] AID - 10.3390/nu18193127 [doi] PST - epublish SO - Nutrients. 2026 Sep 23;18(19):3127. doi: 10.3390/nu18193127. PMID- 42884515 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 19 DP - 2026 Oct 6 TI - Gamified IMU Sensor-Based System for Training Head-Orientation Tasks in Healthy Teenagers: Event-Driven Architecture and Randomised Pilot Feasibility Study. LID - 10.3390/s26196315 [doi] LID - 6315 AB - Sensor systems integrated with gamified environments have increasingly been incorporated into the monitoring of musculoskeletal disorders. This study evaluates the operational feasibility of a motion-capture system based on an inertial measurement unit for training head-orientation tasks. Because a single sensor is placed on the head without thoracic fixation, the system estimates head orientation relative to space rather than isolated cervical motion. The event-driven architecture is organised into five logical layers and uses an asynchronous publish-subscribe bus for data acquisition, sensor fusion through the Madgwick filter, and local rendering in WebGL. A randomised pilot study involving 22 teenagers allocated to two parallel groups (11 per group) was conducted over eight weeks (three sessions per week). Participants were assigned to either the gamified system or a comparable active cervical exercise program. No participant-reported connectivity or hardware events prevented session completion. Self-reported adherence was 100%, and no adverse events were reported. Exploratory analyses showed that both groups reduced task completion time, whereas the reduction in time spent outside the target trajectory was statistically significant only in the experimental group; the between-group comparison of pre-post changes was not statistically significant. These findings indicate the system's operational feasibility in healthy teenagers. FAU - Calleja-Caballero, Andrea AU - Calleja-Caballero A AUID- ORCID: 0000-0002-4674-7025 AD - Department of Nursing and Physiotherapy, University of Salamanca, 37007 Salamanca, Spain. AD - Neurorehabilitation Research Group, Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain. FAU - Sanchez San-Blas, Hector AU - Sanchez San-Blas H AUID- ORCID: 0000-0003-1808-4364 AD - Ontology Engineering Group, ETSI Informaticos, Polytechnic University of Madrid, 28223 Madrid, Spain. FAU - Prieto Prieto, Josue AU - Prieto Prieto J AUID- ORCID: 0000-0002-6379-451X AD - Instituto Universitario de Ciencias de la Educacion (IUCE), University of Salamanca, 37008 Salamanca, Spain. FAU - Perez-Robledo, Fatima AU - Perez-Robledo F AUID- ORCID: 0000-0003-2695-0250 AD - Department of Nursing and Physiotherapy, University of Salamanca, 37007 Salamanca, Spain. AD - Neurorehabilitation Research Group, Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain. FAU - Mendes, Andre Filipe Sales AU - Mendes AFS AUID- ORCID: 0000-0003-0976-2784 AD - Department of Computer Science and Automation, University of Salamanca, 37008 Salamanca, Spain. AD - CREA-Salud Research Group, Salamanca Primary Care Management, Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain. LA - eng GR - PC_TCUE25_026/Universidad de Salamanca/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20261006 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - Feasibility Studies MH - *Head/physiology MH - Head Movements/physiology MH - *Motion Capture/instrumentation MH - Pilot Projects MH - *Video Games PMC - PMC13667489 OTO - NOTNLM OT - BLE sensors OT - edge computing OT - event-driven architecture OT - gamification OT - head orientation OT - human-computer interaction COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/10/06 CRDT- 2026/10/16 01:09 PHST- 2026/09/04 00:00 [received] PHST- 2026/09/30 00:00 [revised] PHST- 2026/10/02 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:09 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - s26196315 [pii] AID - sensors-26-06315 [pii] AID - 10.3390/s26196315 [doi] PST - epublish SO - Sensors (Basel). 2026 Oct 6;26(19):6315. doi: 10.3390/s26196315. PMID- 42884202 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261022 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 19 DP - 2026 Sep 22 TI - Quantifying Physical Activity in Toddlers with Down Syndrome with Wearable Sensors During a Home-Based Mobility Intervention. LID - 10.3390/s26196002 [doi] LID - 6002 AB - BACKGROUND: Quantifying movement during early mobility interventions is important for evaluating intervention participation and progression in toddlers with Down syndrome (DS), but behavioral video coding is time and labor-intensive. This study established and evaluated an activity count cutpoint for distinguishing moderate-to-vigorous physical activity (MVPA) and sedentary-to-light physical activity (SLPA) in toddlers with DS during a home-based mobility intervention using a wearable accelerometer integrated into a body-weight support harness system. METHODS: Video recordings behaviorally coded for MVPA and SLPA were synchronized with accelerometer activity counts binned in 5 s epochs. Receiver operating characteristic curve analysis was used to determine both group-derived and participant-specific activity count cutpoints. RESULTS: The optimal group-derived cutpoint was 141 activity counts per 5 s, demonstrating strong classification performance (AUC = 0.903), with 94.4% sensitivity, 70.2% specificity, and an overall classification accuracy of 79.2%. Participant-specific cutpoints resulted in only minimal improvements in classification performance. CONCLUSIONS: These findings suggest that using individualized cutpoints may not be necessary for classifying MVPA in toddlers with DS during this intervention, though replication in a larger sample is warranted. A standardized activity count cutpoint may provide a practical approach for objectively monitoring activity during home-based mobility interventions. FAU - Athreya, Varsha AU - Athreya V AUID- ORCID: 0009-0007-9982-0824 AD - Department of Computer Engineering, Boston University, Boston, MA 02215, USA. FAU - Mishra, Simoni AU - Mishra S AUID- ORCID: 0009-0004-8389-8748 AD - Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA. FAU - Collimore-Doherty, Ashley N AU - Collimore-Doherty AN AUID- ORCID: 0000-0001-6002-3667 AD - Department of Physical Therapy, Boston University, Boston, MA 02215, USA. FAU - Sutter, Ellen N AU - Sutter EN AUID- ORCID: 0000-0002-9883-8471 AD - Department of Physical Therapy, Boston University, Boston, MA 02215, USA. FAU - Iverson, Jana M AU - Iverson JM AUID- ORCID: 0000-0001-9160-7825 AD - Department of Physical Therapy, Boston University, Boston, MA 02215, USA. LA - eng GR - 1UL1TR001430/Clinical and Translational Science Institute/ GR - 1R21HD111945-01/NH/NIH HHS/United States GR - 1F32HD117600-01/NH/NIH HHS/United States GR - F32 HD117600/HD/NICHD NIH HHS/United States GR - R21 HD111945/HD/NICHD NIH HHS/United States GR - Boston University/ GR - UL1 TR001430/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20260922 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Down Syndrome/physiopathology MH - *Wearable Electronic Devices MH - *Exercise/physiology MH - Child, Preschool MH - Accelerometry/methods/instrumentation MH - Female MH - Male MH - ROC Curve MH - Infant PMC - PMC13667628 OTO - NOTNLM OT - Down syndrome OT - accelerometer OT - intervention OT - physical activity OT - toddler OT - wearable sensor COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/22 CRDT- 2026/10/16 01:08 PHST- 2026/07/20 00:00 [received] PHST- 2026/09/04 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:08 [entrez] PHST- 2026/09/22 00:00 [pmc-release] AID - s26196002 [pii] AID - sensors-26-06002 [pii] AID - 10.3390/s26196002 [doi] PST - epublish SO - Sensors (Basel). 2026 Sep 22;26(19):6002. doi: 10.3390/s26196002. PMID- 42883820 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 27 IP - 19 DP - 2026 Sep 25 TI - Maternal Gestational Hypertension Is Associated with Reduced TSG-6 in Human Milk: Potential Implications for Neonatal Immunological Support. LID - 10.3390/ijms27198573 [doi] LID - 8573 AB - Tumor necrosis factor alpha-stimulated protein 6 (TSG-6) is a potent anti-inflammatory mediator secreted by mesenchymal stem cells (MSCs). In human milk (HM), these cells (human milk mesenchymal stem cells, HM-MSCs) contribute to postnatal programming of the neonatal gastrointestinal immune axis. This study assessed how maternal gestational hypertension and maternal age affect the cytoprotective TSG-6 pool and its associated immunomodulatory microRNA signature in early milk. Early colostrum, 2-4 days postpartum, from healthy mothers and hypertensive patients was analyzed. TSG-6 gene expression in the heterogeneous milk cellular fraction containing HM-MSCs and TSG-6 protein concentration in whole milk were determined using quantitative polymerase chain reaction (qPCR) and Enzyme-Linked Immunosorbent Assay (ELISA), respectively. Comprehensive multivariable General Linear Models (GLMs) were used to adjust for potential confounding variables, including pre-pregnancy Body Mass Index (BMI), gestational age (GA), and gestational diabetes. Additionally, TSG-6 levels were correlated with fetal cord blood gas parameters and previously profiled microRNAs in the cellular fraction. GLM analysis revealed that gestational hypertension remained significantly associated with reduced TSG-6 gene expression in the cellular fraction and total TSG-6 protein concentration in whole milk, regardless of pre-pregnancy BMI or metabolic comorbidities. In healthy pregnancies, exploratory analyses suggested that TSG-6 levels correlated positively with optimal fetal metabolic status (cord blood pH). Importantly, TSG-6 expression showed a strong positive correlation with a signature of immunomodulatory microRNAs (miR) (miR-155-5p, miR-21-3p, miR-126-3p). These microRNAs were concurrently downregulated in the hypertensive group; however, because all hypertensive participants received methyldopa, the independent contributions of hypertension and antihypertensive treatment to these changes cannot be distinguished. Gestational hypertension independently reduces the anti-inflammatory TSG-6 in early breast milk. The concomitant reduction in TSG-6 and its correlated microRNA co-expression pattern indicates an altered immunomodulatory profile within the mammary gland during lactation. We hypothesize that these changes might alter the local immunomodulatory properties of milk in the neonatal gastrointestinal tract. However, because no functional in vitro or in vivo assays were performed, this remains a purely theoretical implication that requires future experimental validation. FAU - Przywara, Dominika AU - Przywara D AUID- ORCID: 0000-0002-6143-9653 AD - Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland. AD - Doctoral School, Medical University of Lublin, 20-093 Lublin, Poland. FAU - Kondracka, Adrianna AU - Kondracka A AD - Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 11 Staszica Str., 20-081 Lublin, Poland. FAU - Petniak, Alicja AU - Petniak A AUID- ORCID: 0000-0001-9926-0870 AD - Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland. FAU - Slyk-Gulewska, Patrycja AU - Slyk-Gulewska P AUID- ORCID: 0009-0008-6201-6514 AD - Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 11 Staszica Str., 20-081 Lublin, Poland. FAU - Drag, Magdalena AU - Drag M AUID- ORCID: 0000-0002-9351-8997 AD - Department of Obstetrics and Pathology of Pregnancy, Medical University of Lublin, 11 Staszica Str., 20-081 Lublin, Poland. FAU - Szymanowska, Urszula AU - Szymanowska U AUID- ORCID: 0000-0001-9692-2111 AD - Department of Biochemistry and Food Chemistry, University of Life Sciences, 8 Skromna Str., 20-704 Lublin, Poland. FAU - Czuba, Monika AU - Czuba M AD - Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland. FAU - Jaremek, Milena AU - Jaremek M AUID- ORCID: 0000-0002-9504-2216 AD - Department of Invertebrate Ecophysiology and Experimental Biology, Faculty of Environmental Biology, University of Life Sciences in Lublin, 54 Doswiadczalna Street, 20-280 Lublin, Poland. FAU - Strachecka, Aneta AU - Strachecka A AD - Department of Invertebrate Ecophysiology and Experimental Biology, Faculty of Environmental Biology, University of Life Sciences in Lublin, 54 Doswiadczalna Street, 20-280 Lublin, Poland. FAU - Kocki, Janusz AU - Kocki J AUID- ORCID: 0000-0002-9541-6353 AD - Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland. FAU - Gil-Kulik, Paulina AU - Gil-Kulik P AUID- ORCID: 0000-0003-3119-981X AD - Department of Clinical Genetics, Medical University of Lublin, 11 Radziwillowska Str., 20-080 Lublin, Poland. LA - eng GR - Grant nr: INT/006/2025/IV-N)./Union of Lublin Universities/ PT - Journal Article DEP - 20260925 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - 0 (TNFAIP6 protein, human) RN - 0 (Cell Adhesion Molecules) RN - 0 (MicroRNAs) SB - IM MH - Humans MH - Female MH - *Cell Adhesion Molecules/metabolism/genetics MH - Pregnancy MH - *Hypertension, Pregnancy-Induced/metabolism/immunology/genetics MH - *Milk, Human/metabolism/immunology MH - MicroRNAs/genetics/metabolism MH - Adult MH - Infant, Newborn MH - Mesenchymal Stem Cells/metabolism PMC - PMC13665462 OTO - NOTNLM OT - HM-MSCs OT - TSG-6 OT - fetal metabolic status OT - gestational hypertension OT - human milk mesenchymal stem cells OT - microRNA COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/25 CRDT- 2026/10/16 01:07 PHST- 2026/08/27 00:00 [received] PHST- 2026/09/20 00:00 [revised] PHST- 2026/09/24 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:07 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - ijms27198573 [pii] AID - ijms-27-08573 [pii] AID - 10.3390/ijms27198573 [doi] PST - epublish SO - Int J Mol Sci. 2026 Sep 25;27(19):8573. doi: 10.3390/ijms27198573. PMID- 42882043 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261016 LR - 20261020 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 19 DP - 2026 Sep 29 TI - Continuous Glucose Monitoring for Women with Gestational Diabetes, CORDELIA: A Multicentric Randomized Controlled Trial, Methodology and Design. LID - 10.3390/jcm15197581 [doi] LID - 7581 AB - Background/Objectives: Gestational diabetes mellitus (GDM) is associated with increased short- and long-term risks for both mother and child. Screening and treatment between 24 and 30 weeks' gestation reduces adverse pregnancy outcomes, while emerging evidence suggests that earlier diagnosis and treatment (<20 weeks') in high-risk populations may further improve neonatal outcomes. Currently, self-monitoring of blood glucose (SMBG) remains the standard of care for management but provides only intermittent glycemic data and limited insight into overall glucose patterns. Real-time continuous glucose monitoring (rt-CGM) has transformed management in pregnancies complicated by type 1 diabetes but has shown conflicting results in GDM; it is thus unclear whether similar benefits may extend to women with GDM, including women with early GDM. Methods: The Continuous Glucose Monitoring for Women With Gestational Diabetes (CORDELIA) study is an ongoing, large, open-label, multicenter randomized controlled trial conducted across 14 centers in Belgium and two centers in Australia. Women diagnosed with GDM are randomized in a 1:1 ratio to either rt-CGM (intervention group) or standard care with SMBG (control group). Both women with early GDM diagnosed before 20 weeks' gestation and those diagnosed between 24.0 and 29.6 weeks' gestation are included. Participants attend the following visits: baseline visit at GDM diagnosis, an additional visit at 20.0-23.9 weeks' (if early GDM), 31.0-33.6 weeks' and 36.0-38.6 weeks', and a postpartum oral glucose tolerance test (OGTT) assessment (6.0-23.6 weeks after delivery). At each visit, clinical assessment, HbA1c, and (blinded) CGM are evaluated, alongside validated patient-reported outcome questionnaires. The primary objective is to compare the incidence of a composite of adverse pregnancy outcomes between the rt-CGM and SMBG groups. The primary outcome is a composite of adverse pregnancy outcomes including preterm delivery <37 weeks, LGA [customized percentiles according to Gestation Related Optimal Weight chart (GROW)], neonatal hypoglycemia requiring intravenous dextrose, neonatal intensive care unit (NICU) admission > 24 h, neonatal respiratory distress, stillbirth or neonatal death, phototherapy, birth trauma, and shoulder dystocia. Secondary outcomes include maternal glycemia, insulin use, pregnancy and neonatal outcomes, glycemic variability, patient-reported outcomes, and prespecified secondary analyses according to timing of GDM diagnosis and maternal BMI. Trial Registration: ClinicalTrials.gov: NCT06310356. First posted: 15 March 2024. FAU - Geerts, Ina AU - Geerts I AUID- ORCID: 0009-0004-2803-7013 AD - Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinology, KU Leuven, 3000 Leuven, Belgium. FAU - Yu, Catherine AU - Yu C AUID- ORCID: 0009-0005-7013-8640 AD - Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinology, KU Leuven, 3000 Leuven, Belgium. FAU - Bochanen, Niels AU - Bochanen N AUID- ORCID: 0000-0002-1265-9086 AD - Department of Endocrinology-Diabetology-Metabolism, Antwerp University Hospital, 2650 Edegem, Belgium. FAU - Heyns, Ellen AU - Heyns E AD - Department of Endocrinology, General Hospital Groeninge Kortrijk, 8500 Kortrijk, Belgium. FAU - Pottelbergh, Inge Van AU - Pottelbergh IV AD - Department of Endocrinology, AZORG Aalst, 9300 Aalst, Belgium. FAU - Morrens, Astrid AU - Morrens A AD - Department of Endocrinology, ZAS Palfijn, 2170 Merksem, Belgium. FAU - Coremans, Peter AU - Coremans P AD - Department of Endocrinology-Diabetology, Vitaz, 9100 Sint-Niklaas, Belgium. FAU - Philips, Jean-Christophe AU - Philips JC AD - Department of Diabetology, Nutrition and Metabolic Diseases, CHU de Liege, 4000 Liege, Belgium. FAU - Carton, Tiphaine AU - Carton T AD - Department of Endocrinology, Erasme Hospital, 1070 Brussels, Belgium. FAU - Vandewalle, Sara AU - Vandewalle S AUID- ORCID: 0000-0001-8422-4973 AD - Department of Endocrinology-Diabetology, AZ Sint-Jan Brugge, 8000 Brugge, Belgium. FAU - Marlier, Joke AU - Marlier J AUID- ORCID: 0000-0002-9500-608X AD - Department of Endocrinology, UZ Gent, 9000 Gent, Belgium. FAU - Van Boxelaer, Inge AU - Van Boxelaer I AUID- ORCID: 0009-0000-0009-9598 AD - Department of Endocrinology, AZ Sint Lucas Gent, 9000 Gent, Belgium. FAU - Winne, Linsey AU - Winne L AD - Department of Endocrinology, AZ Oostende, 8400 Oostende, Belgium. FAU - Bollaerts, Kathleen AU - Bollaerts K AD - Department of Endocrinology, AZ Sint Maarten Mechelen, 2800 Mechelen, Belgium. FAU - Lee, Dahae AU - Lee D AD - Department of Endocrinology, Imelda Bonheiden, 2820 Bonheiden, Belgium. FAU - Simmons, David AU - Simmons D AUID- ORCID: 0000-0003-0560-0761 AD - School of Medicine, Western Sydney University, Sydney, NSW 2560, Australia. FAU - Sweeting, Arianne AU - Sweeting A AUID- ORCID: 0000-0001-6843-6247 AD - Department of Endocrinology, Royal Prince Alfred Hospital and Charles Perkins Centre, University of Sydney, Sydney, NSW 2050, Australia. FAU - Laenen, Annouschka AU - Laenen A AUID- ORCID: 0000-0002-1371-442X AD - Leuven Biostatistics and Statistical Bioinformatics Centre, KU Leuven, 3000 Leuven, Belgium. FAU - Mathieu, Chantal AU - Mathieu C AD - Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinology, KU Leuven, 3000 Leuven, Belgium. AD - Department of Endocrinology, University Hospitals Leuven, 3000 Leuven, Belgium. FAU - Benhalima, Katrien AU - Benhalima K AUID- ORCID: 0000-0002-3325-0263 AD - Department of Chronic Diseases and Metabolism, Clinical and Experimental Endocrinology, KU Leuven, 3000 Leuven, Belgium. AD - Department of Endocrinology, University Hospitals Leuven, 3000 Leuven, Belgium. LA - eng SI - ClinicalTrials.gov/NCT06310356 GR - Abbott Diabetes Care/ GR - LifeScan/ GR - Research Foundation - Flanders/ PT - Journal Article DEP - 20260929 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13665732 OTO - NOTNLM OT - continuous glucose monitoring OT - early gestational diabetes OT - gestational diabetes mellitus OT - pregnancy outcomes COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 PMCR- 2026/09/29 CRDT- 2026/10/16 01:01 PHST- 2026/07/10 00:00 [received] PHST- 2026/09/06 00:00 [revised] PHST- 2026/09/25 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/16 01:01 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - jcm15197581 [pii] AID - jcm-15-07581 [pii] AID - 10.3390/jcm15197581 [doi] PST - epublish SO - J Clin Med. 2026 Sep 29;15(19):7581. doi: 10.3390/jcm15197581. PMID- 42881772 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261016 LR - 20261020 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 19 DP - 2026 Oct 6 TI - Association of Halliwick-Based Aquatic Physical Activity with Health-Related Quality of Life in Children and Adolescents with Autism Spectrum Disorder: A Cross-Sectional Comparative Study. LID - 10.3390/healthcare14193323 [doi] LID - 3323 AB - BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by persistent deficits in social communication and interaction, accompanied by restricted and repetitive patterns of behavior, interests, or activities. Given the considerable heterogeneity in symptom severity and functional abilities, children with ASD require individualized educational and therapeutic interventions. Among the non-pharmacological approaches used to support this population, aquatic physical activity has emerged as a promising intervention. MATERIAL AND METHODS: The study included 45 children with ASD (ICD-11 code 6A02), comprising 19 girls and 26 boys, aged 8-17 years. Two groups were compared: Group G1, consisting of children and adolescents who had participated in Halliwick-based aquatic physical activity for at least 3 months, and Group G2, without aquatic activities. Health-related quality of life was assessed using the validated Polish version of the KIDSCREEN-52 questionnaire. RESULTS: Children with ASD who participated in Halliwick-based aquatic physical activity (G1) had higher mean scores in all KIDSCREEN-52 domains. However, statistically significant differences were only found in the following domains: Psychological Well-Being, Moods and Emotions, Self-Perception, Autonomy, Financial Resources, and School Environment. Overall health-related quality of life, measured by the KIDSCREEN-10, compared with children who did not participate in aquatic activities. CONCLUSIONS: Halliwick-based aquatic physical activity was associated with better quality of life in children and adolescents with ASD, with higher scores observed according to sex, but further research is needed to confirm these findings. FAU - Stefanska, Malgorzata AU - Stefanska M AUID- ORCID: 0000-0003-2070-8535 AD - Faculty of Physiotherapy, Wroclaw University of Health and Sport Science, al. Paderewskiego 35, 51-612 Wroclaw, Poland. FAU - Smetek, Wiktoria AU - Smetek W AD - Reh-Medica Marek Smiech, ul. Odrzanska 7, 47-224 Kedzierzyn-Kozle, Poland. FAU - Kowalska, Joanna AU - Kowalska J AUID- ORCID: 0000-0002-5232-1688 AD - Faculty of Physiotherapy, Wroclaw University of Health and Sport Science, al. Paderewskiego 35, 51-612 Wroclaw, Poland. FAU - Ptak, Agnieszka AU - Ptak A AUID- ORCID: 0000-0002-8396-5267 AD - Faculty of Physiotherapy, Wroclaw University of Health and Sport Science, al. Paderewskiego 35, 51-612 Wroclaw, Poland. LA - eng PT - Journal Article DEP - 20261006 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13665036 OTO - NOTNLM OT - Halliwick method OT - KIDSSCREEN OT - aquatic physical activity OT - autism spectrum disorders OT - physical activity OT - quality of life COIS- Author Wiktoria Smetek was employed by Reh-Medica Marek Smiech. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/16 05:32 MHDA- 2026/10/16 05:33 PMCR- 2026/10/06 CRDT- 2026/10/16 01:01 PHST- 2026/07/23 00:00 [received] PHST- 2026/09/12 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/16 05:33 [medline] PHST- 2026/10/16 05:32 [pubmed] PHST- 2026/10/16 01:01 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - healthcare14193323 [pii] AID - healthcare-14-03323 [pii] AID - 10.3390/healthcare14193323 [doi] PST - epublish SO - Healthcare (Basel). 2026 Oct 6;14(19):3323. doi: 10.3390/healthcare14193323. PMID- 42881744 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261016 LR - 20261020 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 19 DP - 2026 Oct 3 TI - The Psychosocial Pathways of Expectancy-Value Beliefs, Physical Fitness, and Executive Function Among Adolescents. LID - 10.3390/healthcare14193305 [doi] LID - 3305 AB - Background/Objectives: Adequate physical fitness has been associated with cognitive health among adolescents, and psychosocial processes may help explain this relationship. However, evidence regarding the mechanisms linking physical fitness and cognitive health remains limited. Guided by expectancy-value theory, this study examined the direct and indirect effects of expectancy-value beliefs on executive function through physical fitness among adolescents. Methods: A prospective research design was used. Participants were 424 adolescents (58% female; Mage = 12.72 years, SD = 0.93) recruited from the southwestern United States. Physical fitness components, including cardiovascular fitness, muscular fitness, flexibility, and body mass index (BMI), were assessed using the FITNESSGRAM((R)) test battery. Expectancy-value beliefs and executive function were measured using validated self-report instruments. Structural equation modeling was conducted to examine the proposed relationships. Results: Expectancy-value beliefs were significantly associated with all physical fitness components (rs ranged from -0.86 to 0.46, ps < 0.01) except flexibility. Cardiovascular fitness and muscular fitness were negatively associated with executive function scores (rs ranged from -0.29 to -0.21, ps < 0.01), whereas BMI was positively associated with executive function scores. The proposed model demonstrated an acceptable fit (chi(2)/df = 284.16/113, p < 0.001; CFI = 0.90; RMSEA = 0.06, 90% CI [0.05, 0.07]). There was a significant indirect effect of expectancy-value beliefs on executive function through physical fitness (beta = -0.11). The model explained 12% of the variance in physical fitness and 9% of the variance in executive function. Conclusions: The findings provide evidence for the proposed psychosocial mediation model linking expectancy-value beliefs, physical fitness, and executive function among adolescents. It suggests strategies that strengthen perceived competence and task values may improve physical fitness and, in turn, enhance executive function. FAU - Shen, Dijun AU - Shen D AD - Department of Physical Education, Shanghai Lixin University Accounting and Finance, Shanghai 201620, China. FAU - Bao, Sarina AU - Bao S AD - Department of Earth and Planetary Science, Graduate School of Science, The University of Tokyo, Tokyo 113-0033, Japan. FAU - Zhang, Xiaoxia AU - Zhang X AUID- ORCID: 0000-0001-5076-9035 AD - School of Sport Sciences, West Virginia University, Morgantown, WV 26506-6116, USA. LA - eng PT - Journal Article DEP - 20261003 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13664947 OTO - NOTNLM OT - adolescents OT - cognitive health OT - executive function OT - expectancy-value beliefs OT - physical fitness OT - psychosocial mechanisms OT - structural equation modeling COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:32 MHDA- 2026/10/16 05:33 PMCR- 2026/10/03 CRDT- 2026/10/16 01:01 PHST- 2026/07/30 00:00 [received] PHST- 2026/09/22 00:00 [revised] PHST- 2026/09/30 00:00 [accepted] PHST- 2026/10/16 05:33 [medline] PHST- 2026/10/16 05:32 [pubmed] PHST- 2026/10/16 01:01 [entrez] PHST- 2026/10/03 00:00 [pmc-release] AID - healthcare14193305 [pii] AID - healthcare-14-03305 [pii] AID - 10.3390/healthcare14193305 [doi] PST - epublish SO - Healthcare (Basel). 2026 Oct 3;14(19):3305. doi: 10.3390/healthcare14193305. PMID- 42881734 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261016 LR - 20261020 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 19 DP - 2026 Oct 2 TI - Assessment of Methods to Estimate Resting and Total Energy Expenditure in Children and Adolescents with Cerebral Palsy: A Scoping Review. LID - 10.3390/healthcare14193295 [doi] LID - 3295 AB - Background/Objectives: Accurate assessment of resting energy expenditure (REE) and total energy expenditure (TEE) in children with cerebral palsy (CP) remains challenging. This review aimed to map and synthesize the existing evidence on methods used to estimate REE and TEE in children and adolescents with CP and identify their limitations and research gaps. Methods: A structured search was conducted in PubMed, Scopus, SciELO, EBSCO, and Embase for English or Spanish language articles published with no restrictions on publication date until September 2026. Studies that included children or adolescents from 0 to 19 years with a confirmed diagnosis of CP and that reported measured or estimated REE, basal metabolic rate (BMR), or TEE were included. Results: Nineteen studies met the inclusion criteria. Indirect calorimetry (IC) was the most frequently used method for measuring REE (n = 11, 57.9%), whereas doubly labeled water (DLW) was the reference method for TEE (n = 6, 31.6%). Standard predictive equations developed for TDC were used in three studies (15.8%) and frequently overestimated REE. In contrast, CP-specific predictive equations were less used and showed better estimations against reference methods. BIA-derived estimates, anthropometric approaches, and biomarker-based models remain insufficiently validated. Conclusions: IC remains the reference method for individualized assessment of REE, whereas DLW is the reference method for measuring TEE. Predictive equations for TDC are not recommended for children with CP. Further validation studies comparing BIA-derived estimates and CP-specific equations against reference methods are needed, particularly across Gross Motor Function Classification System (GMFCS) levels, nutritional status, and feeding method. FAU - Garcia-Iniguez, Jorge Abraham AU - Garcia-Iniguez JA AD - Instituto de Nutricion Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico. AD - Escuela de Nutricion, Universidad Autonoma de Guadalajara, Zapopan 45129, Jalisco, Mexico. FAU - Garcia-Contreras, Andrea Anais AU - Garcia-Contreras AA AUID- ORCID: 0000-0001-8750-6458 AD - Instituto de Nutricion Humana, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Guadalajara 44340, Jalisco, Mexico. LA - eng PT - Journal Article PT - Review DEP - 20261002 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13665139 OTO - NOTNLM OT - basal metabolic rate OT - cerebral palsy OT - children OT - doubly labeled water OT - energy expenditure OT - indirect calorimetry OT - resting energy expenditure OT - total energy expenditure COIS- The authors declare no conflicts of interest. EDAT- 2026/10/16 05:32 MHDA- 2026/10/16 05:33 PMCR- 2026/10/02 CRDT- 2026/10/16 01:01 PHST- 2026/08/05 00:00 [received] PHST- 2026/09/24 00:00 [revised] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/16 05:33 [medline] PHST- 2026/10/16 05:32 [pubmed] PHST- 2026/10/16 01:01 [entrez] PHST- 2026/10/02 00:00 [pmc-release] AID - healthcare14193295 [pii] AID - healthcare-14-03295 [pii] AID - 10.3390/healthcare14193295 [doi] PST - epublish SO - Healthcare (Basel). 2026 Oct 2;14(19):3295. doi: 10.3390/healthcare14193295. PMID- 42881684 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261016 LR - 20261020 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 19 DP - 2026 Oct 1 TI - Self-Reported Training Needs and Continuing-Education Preferences of the School Medicine Workforce in Romania: A National Cross-Sectional Survey. LID - 10.3390/healthcare14193245 [doi] LID - 3245 AB - BACKGROUND/OBJECTIVES: The continuing professional development (CPD) needs of school medical personnel in Romania have not been characterised at a national scale. We quantified the workforce's self-reported training needs to inform a national CPD programme. METHODS: We conducted a cross-sectional, self-administered online survey (July-September 2025) of school physicians, nurses, dental physicians, and dental nurses, recruited by open invitation through the national school-medicine association's channels. Training needs (59 role-specific items in seven thematic domains) were rated on a 5-point Likert scale; internal consistency, cross-role contrasts, and regression predictors of the overall training-need score were assessed. RESULTS: The sample comprised 683 respondents (97.4% female; all eight development regions). Interest in further training was near-universal (99.0%); respondents preferred blended delivery (50.2%) and practical simulations (63.4%), with time (39.8%) and cost (37.5%) the leading barriers. Among generalist physicians and nurses, the highest-rated needs were emotional and school-adjustment disorders (59% high or very high need), major emergency first aid (58%), and principles of healthy nutrition (56%); across all roles, communicating with parents ranked highest (53%). Training needs differed by profession for digital skills, ethics, and social and child rights and between generalist professions for the clinical and health-education domains (p 30 mm managed at a tertiary pediatric surgery center between January 2023 and January 2026. Clinical presentation, US characteristics, management, and outcomes were evaluated. Height and weight measurements were retrospectively retrieved when available, and body mass index (BMI) was calculated and analyzed as a continuous variable. Multivariable logistic regression was used to identify factors independently associated with surgical intervention and ovarian torsion. Receiver operating characteristic (ROC) analysis was used to determine the optimal lesion diameter threshold for surgical intervention. A exploratory three-level clinical risk stratification framework was subsequently developed using the ROC-derived 60-mm lesion diameter threshold and the presence of abdominal/pelvic pain. RESULTS: Among 112 patients, 26 (23.2%) underwent surgical intervention, whereas 86 (76.8%) were managed conservatively. Surgical indications included ovarian torsion, complex adnexal masses, and persistent or enlarging cysts. Maximum lesion diameter was the strongest independent predictor of both surgical intervention and ovarian torsion. BMI was available for 95 patients (84.8%) and was not independently associated with surgical intervention or significantly different according to ovarian torsion status. The 60-mm threshold provided the best discrimination for surgical intervention. Surgical intervention occurred in 5/75 (6.7%), 2/8 (25.0%), and 19/29 (65.5%) patients in the low-, intermediate-, and high-risk groups, respectively (Fisher-Freeman-Halton exact test, p < 0.001). Ovarian torsion occurred in 2/75 (2.7%), 0/8 (0%), and 11/29 (37.9%) patients, respectively (Fisher-Freeman-Halton exact test, p < 0.001). CONCLUSIONS: Maximum lesion diameter was the strongest independent predictor of surgical intervention and ovarian torsion. BMI was not significantly associated with either outcome in the available anthropometric data. The new exploratory risk stratification framework showed distinct clinical patterns across risk categories but requires prospective external validation before clinical use. CI - (c) 2026 Japan Society of Obstetrics and Gynecology. FAU - Oztas, Tulin AU - Oztas T AUID- ORCID: 0000-0002-1010-3324 AD - Department of Pediatric Surgery, Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkiye. FAU - Asir, Aysegul AU - Asir A AD - Department of Pediatrics, Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkiye. LA - eng PT - Journal Article PL - Australia TA - J Obstet Gynaecol Res JT - The journal of obstetrics and gynaecology research JID - 9612761 SB - IM MH - Humans MH - Female MH - *Ovarian Torsion/surgery/diagnostic imaging/epidemiology MH - Adolescent MH - Retrospective Studies MH - *Ovarian Cysts/surgery/diagnostic imaging/complications/pathology MH - Ultrasonography OTO - NOTNLM OT - adolescent OT - ovarian cysts OT - ovarian torsion OT - risk factors OT - surgical procedures EDAT- 2026/10/16 05:33 MHDA- 2026/10/16 05:34 CRDT- 2026/10/15 23:58 PHST- 2026/09/07 00:00 [revised] PHST- 2026/07/26 00:00 [received] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/10/16 05:34 [medline] PHST- 2026/10/16 05:33 [pubmed] PHST- 2026/10/15 23:58 [entrez] AID - e70504 [pii] AID - 10.1111/jog.70504 [doi] PST - ppublish SO - J Obstet Gynaecol Res. 2026 Oct;52(10):e70504. doi: 10.1111/jog.70504. PMID- 42880881 OWN - NLM STAT- Publisher LR - 20261015 IS - 2380-9426 (Electronic) IS - 2380-9418 (Linking) DP - 2026 Oct 15 TI - Advancing Global Health Initiative Through Pediatric Vitamin A Supplementation. LID - JDNP-2025-0082.R1 [pii] LID - 10.1891/JDNP-2025-0082 [doi] AB - Background: Malnutrition, particularly vitamin A deficiency, affects approximately 49% of children aged 6-59 months in sub-Saharan Africa, increasing the risks of morbidity, mortality, poor growth, and preventable blindness. Tanzania has followed the World Health Organization's (WHO) guidelines for biannual vitamin A supplementation (VAS) since 2004, but rural access remains limited. A preliminary assessment at a rural Tanzanian day care showed only 29% VAS coverage, indicating a substantial gap in coverage. Objective: To improve nutritional health among children aged 6-59 months through a comprehensive VAS program at a local day care in Tanzania. Methods: An interdisciplinary team coordinated structural and workflow changes, secured the supplement through established partnerships, and administered it to all 21 eligible children per WHO protocols. Results: All 21 eligible children enrolled in the day care received their initial dose of VAS at implementation. VAS was sustained at 100% among 29 children, including the 21 original children and 8 newly enrolled. Conclusions: A structured, community-based supplementation program in rural Tanzania successfully addressed critical gaps in vitamin A access for children aged 6-59 months. Implications for Nursing: This quality improvement project demonstrates the feasibility of global health collaboration through strategic planning, stakeholder engagement, and context sensitivity to improve child health outcomes. CI - (c) 2026 Springer Publishing Company. FAU - Watt, Tenica K AU - Watt TK AD - School of Nursing, University of Maryland, Baltimore, MD, USA twatt001@umaryland.edu. FAU - Alessandrini, Erica A AU - Alessandrini EA AD - School of Nursing, University of Maryland, Baltimore, MD, USA. FAU - Fitzpatrick, Suzanna AU - Fitzpatrick S AD - School of Nursing, University of Maryland, Baltimore, MD, USA. FAU - Franquiz, Renee AU - Franquiz R AD - School of Nursing, University of Maryland, Baltimore, MD, USA. FAU - Jones-Swing, Taylor AU - Jones-Swing T AD - School of Nursing, University of Maryland, Baltimore, MD, USA. FAU - Snyder, B Elias AU - Snyder BE AD - River Rock Global Collective, Baltimore, MD, USA. LA - eng PT - Journal Article DEP - 20261015 PL - United States TA - J Dr Nurs Pract JT - Journal of doctoral nursing practice JID - 101685366 SB - IM OTO - NOTNLM OT - Africa OT - child mortality OT - morbidity OT - vitamin A supplement EDAT- 2026/10/15 23:31 MHDA- 2026/10/15 23:31 CRDT- 2026/10/15 21:04 PHST- 2026/10/15 23:31 [medline] PHST- 2026/10/15 23:31 [pubmed] PHST- 2026/10/15 21:04 [entrez] AID - JDNP-2025-0082 [pii] AID - 10.1891/JDNP-2025-0082 [doi] PST - aheadofprint SO - J Dr Nurs Pract. 2026 Oct 15:JDNP-2025-0082.R1. doi: 10.1891/JDNP-2025-0082. PMID- 42880628 OWN - NLM STAT- Publisher LR - 20261015 IS - 1534-4436 (Electronic) IS - 1081-1206 (Linking) DP - 2026 Oct 15 TI - Pediatric Alpha-Gal Syndrome: From Missed Diagnosis to the Burden of Avoidance. LID - S1081-1206(26)01272-X [pii] LID - 10.1016/j.anai.2026.10.012 [doi] AB - BACKGROUND: Pediatric alpha-gal syndrome remains underrecognized because delayed reactions disconnect symptoms from mammalian exposure and gastrointestinal-only presentations may bypass allergy evaluation. Overly broad avoidance may subsequently impose nutritional and psychosocial burden during growth. OBJECTIVE: To synthesize pediatric evidence and provide a directed management framework emphasizing diagnostic delay, least-restrictive avoidance, nutritional burden, natural history, and reassessment. DATA SOURCES: A literature search was conducted using PubMed/MEDLINE for articles published through August 2026. STUDY SELECTIONS: Pediatric and age-stratified primary studies were prioritized. Adult and mixed-age studies informed areas with limited pediatric evidence, with consideration of their applicability to children. METHODS: Evidence was qualitatively synthesized by source; no risk-of-bias assessment was performed. RESULTS: Pediatric cohorts document prolonged diagnostic delay and frequent gastrointestinal-predominant presentations. Tick exposure is a key etiologic and diagnostic clue, but lack of a recalled bite does not exclude alpha-gal syndrome. Diagnosis requires a compatible delayed phenotype plus detectable alpha-gal-specific IgE; sensitization alone does not establish alpha-gal syndrome. Mammalian meat and internal organ meat are the core exclusions, whereas tolerated dairy should be preserved and additional restrictions individualized. Potential mammalian origin of a medication or vaccine warrants product-specific assessment rather than blanket avoidance. No prospective pediatric study has quantified dietary intake, nutrient status, growth, bone health, or quality of life. A 2026 meta-analysis of 1,162 predominantly adult or mixed-age patients found symptomatic improvement in 86.5% but complete resolution in 42.7%; no pediatric remission rate or validated challenge/reintroduction protocol exists. CONCLUSION: Care should combine cross-specialty evaluation, phenotype-directed testing, least-restrictive avoidance, nutritional surveillance, tick-bite prevention, emergency preparedness, and planned reassessment toward the broadest safely tolerated diet. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Miliordos, Konstantinos AU - Miliordos K AD - Pediatric Allergy Unit, Department of Pediatrics, General University Hospital of Patras, Patras, Greece. Electronic address: mhlcon95@gmail.com. FAU - Triga, Maria AU - Triga M AD - Pediatric Allergy Unit, Department of Pediatrics, General University Hospital of Patras, Patras, Greece. LA - eng PT - Journal Article PT - Review DEP - 20261015 PL - United States TA - Ann Allergy Asthma Immunol JT - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JID - 9503580 SB - IM OTO - NOTNLM OT - alpha-gal syndrome OT - children OT - delayed diagnosis OT - elimination diet OT - natural history OT - nutritional burden OT - oral food challenge OT - reintroduction EDAT- 2026/10/15 23:30 MHDA- 2026/10/15 23:30 CRDT- 2026/10/15 20:31 PHST- 2026/09/04 00:00 [received] PHST- 2026/10/08 00:00 [revised] PHST- 2026/10/09 00:00 [accepted] PHST- 2026/10/15 23:30 [medline] PHST- 2026/10/15 23:30 [pubmed] PHST- 2026/10/15 20:31 [entrez] AID - S1081-1206(26)01272-X [pii] AID - 10.1016/j.anai.2026.10.012 [doi] PST - aheadofprint SO - Ann Allergy Asthma Immunol. 2026 Oct 15:S1081-1206(26)01272-X. doi: 10.1016/j.anai.2026.10.012. PMID- 42879776 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261020 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Oct 15 TI - Socially Embedded Digital Coaching Platform to Promote Healthy Lifestyle and Mental Health in Underprivileged (Pre)Pregnant Couples and Young Families (Our Smart Family Buddy Program): Protocol for a Mixed Methods Study. PG - e88913 LID - 10.2196/88913 [doi] LID - e88913 AB - BACKGROUND: The early life course, that is, from preconception up until the first 1000 days of life, is pivotal for optimizing parental and child health. In deprived settings, unfavorable lifestyle behaviors and poor mental health are more prevalent, while access to effective, context-sensitive support is limited. Digital interventions combined with community-based approaches may help address these disparities. OBJECTIVE: This protocol describes the methodology and initial progress of the Our Smart Family Buddy (OSFB) program, which aims to develop, implement, and evaluate a socially embedded digital coaching platform to improve nutrition and mental well-being among (pre)pregnant couples and families in deprived neighborhoods. METHODS: The OSFB program is a multiphase mixed methods program conducted within a transdisciplinary consortium consisting of 6 interrelated work packages. The program is structured in 3 phases: phase 1, exploration and preparation; phase 2, cocreation, design, and development; and phase 3, prototype evaluation and optimization. Data collection includes quantitative questionnaires, qualitative interviews and focus groups, and digital user data from the platform. The primary outcomes include lifestyle behaviors (nutrition and sleep), mental well-being, user engagement, and implementation outcomes, including feasibility, acceptability, and reach. RESULTS: The program was funded in 2022. A transdisciplinary consortium was established in 2023. Data collection and analysis for phase 1 were conducted between 2023 and 2025, including literature reviews and exploratory interviews. A deprived neighborhood in the municipality of Rotterdam, the Netherlands, was selected as the target neighborhood. The target population was defined as (pre)pregnant couples and families with a child aged <4 years. Phase 2 is ongoing (2024-2026), focusing on iterative design through locally established field labs and community building. Phase 3 is planned for 2026 to 2028. CONCLUSIONS: This protocol describes a socially embedded, multiphase approach to developing and implementing a digital coaching intervention for families in vulnerable circumstances. Through a transdisciplinary approach within a real-world, local community setting, the OSFB program aims to develop a context-sensitive intervention to support sustainable behavior change in early life. CI - (c) Teuntje Wieles, Hilmar Bijma, Ageeth Rosman, Ineke Bolt, Marina Bos-de Vos, Isabelle Fabbricotti, Annelli Janssen, Koen Joosten, Evangelos Niforatos, Valentijn Visch, Regine Steegers-Theunissen. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Wieles, Teuntje AU - Wieles T AUID- ORCID: 0009-0005-4419-1421 AD - Department of Obstetrics & Gynecology, Erasmus MC, Dr Molewaterplein 40, Rotterdam, The Netherlands, 31 0107040704. FAU - Bijma, Hilmar AU - Bijma H AUID- ORCID: 0000-0002-5800-8051 AD - Department of Obstetrics & Gynecology, Erasmus MC, Dr Molewaterplein 40, Rotterdam, The Netherlands, 31 0107040704. AD - Department of Care Ethics, University of Humanistic Studies, Utrecht, The Netherlands. FAU - Rosman, Ageeth AU - Rosman A AUID- ORCID: 0000-0003-3751-2950 AD - Department of Obstetrics & Gynecology, Erasmus MC, Dr Molewaterplein 40, Rotterdam, The Netherlands, 31 0107040704. AD - Innovation Center of Care, Rotterdam University of Applied Sciences, Rotterdam, South Holland, The Netherlands. FAU - Bolt, Ineke AU - Bolt I AUID- ORCID: 0000-0002-9575-1354 AD - Section Medical Ethics, Philosophy and History of Medicine, Department of Public Health, Erasmus MC, Rotterdam, The Netherlands. FAU - Bos-de Vos, Marina AU - Bos-de Vos M AUID- ORCID: 0000-0001-7613-891X AD - Faculty of Industrial Design Engineering, Delft University of Technology, Delft, The Netherlands. FAU - Fabbricotti, Isabelle AU - Fabbricotti I AUID- ORCID: 0000-0003-2369-4781 AD - Department of Health Services Management and Organization, Erasmus School of Health Policy & Management, Erasmus University Rotterdam, Rotterdam, The Netherlands. FAU - Janssen, Annelli AU - Janssen A AUID- ORCID: 0000-0003-0592-4803 AD - The Dutch Research Institute for Transitions (DRIFT), Erasmus University Rotterdam, Rotterdam, South Holland, The Netherlands. FAU - Joosten, Koen AU - Joosten K AUID- ORCID: 0000-0002-0504-2475 AD - Department of Neonatal and Pediatric Intensive Care, Erasmus MC, Rotterdam, The Netherlands. FAU - Niforatos, Evangelos AU - Niforatos E AUID- ORCID: 0000-0002-0484-4214 AD - Faculty of Industrial Design Engineering, Delft University of Technology, Delft, The Netherlands. FAU - Visch, Valentijn AU - Visch V AUID- ORCID: 0000-0001-5502-1691 AD - Faculty of Industrial Design Engineering, Delft University of Technology, Delft, The Netherlands. FAU - Steegers-Theunissen, Regine AU - Steegers-Theunissen R AUID- ORCID: 0000-0002-4353-5756 AD - Department of Obstetrics & Gynecology, Erasmus MC, Dr Molewaterplein 40, Rotterdam, The Netherlands, 31 0107040704. AD - Sophia's Children Hospital, Erasmus MC, Rotterdam, Netherlands. LA - eng PT - Journal Article DEP - 20261015 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - *Healthy Lifestyle MH - Female MH - *Mental Health MH - *Mentoring/methods/standards MH - Pregnancy MH - *Health Promotion/methods MH - Digital Health PMC - PMC13671683 OTO - NOTNLM OT - cocreation OT - deprived neighborhood OT - digital lifestyle platform OT - periconception health OT - vulnerable families COIS- Conflicts of Interest: The content of the programs Smarter Pregnancy App, Sneller Zwanger App and Slimmer Eten met je Kind are further developed to create the described prototype and minimum viable Family Buddy. RS-T is an initiator and creator of these programs and because of their affiliation, the Erasmus MC is owner of these programs. Dear Health, as part of Topicus, has a nonexclusive pilot license of www.slimmerzwanger.nl and www.smarterpregnancy.co.uk (May 2025-May 2027). EDAT- 2026/10/15 23:30 MHDA- 2026/10/15 23:31 PMCR- 2026/10/15 CRDT- 2026/10/15 19:39 PHST- 2025/12/05 00:00 [received] PHST- 2026/05/18 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/10/15 23:31 [medline] PHST- 2026/10/15 23:30 [pubmed] PHST- 2026/10/15 19:39 [entrez] PHST- 2026/10/15 00:00 [pmc-release] AID - v15i1e88913 [pii] AID - 88913 [pii] AID - 10.2196/88913 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Oct 15;15:e88913. doi: 10.2196/88913. PMID- 42879323 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261017 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Oct 15 TI - Feasibility of High-Intensity Interval Exercise in Young Adult Survivors of Pediatric Brain Tumor and Young Adults With Isocitrate Dehydrogenase-Mutant Gliomas (HYPE): Protocol for a Randomized Controlled Trial. PG - e88718 LID - 10.2196/88718 [doi] LID - e88718 AB - BACKGROUND: Young adult survivors of pediatric brain tumors and young adult patients with isocitrate dehydrogenase (IDH) mutant gliomas are at risk for cognitive impairment, reduced physical fitness and function, as well as poor health-related quality of life (HRQOL) and psychosocial health. Exercise improves these outcomes; however, both populations remain understudied with respect to exercise interventions. High-intensity interval training (HIIT) is a promising intervention, as it is time-efficient, safe, tolerable, enhances cognition in healthy young adults, and improves physical fitness and quality of life in adult patients and survivors with cancer. However, the feasibility of HIIT is not yet understood in survivors of pediatric brain tumors and patients with IDH-mutant glioma. OBJECTIVE: The HYPE study is a pilot randomized controlled trial that aims to (1) determine the feasibility of a HIIT exercise intervention for young adult survivors of pediatric brain tumors and patients with IDH-mutant glioma, (2) determine the preliminary efficacy of HIIT to improve physical fitness and function, cognition, HRQOL, and psychosocial health, and (3) explore exercise sustainability and the impact of social determinants of health on study outcomes. METHODS: A total of 30 young adult survivors of pediatric brain tumors and patients with IDH-mutant glioma (18-45 years of age) will be randomized to an exercise or control group. The exercise group performs virtually supervised HIIT 3 times per week for 16 weeks, followed by 16 weeks of self-directed exercise. Exercise involves indoor cycling, and sessions include 20 minutes of high- and low-intensity intervals (high intensity=60-s 60%-90% peak power output; low intensity=60-s 10% peak power output), and a 5-minute warm-up and cool-down. The control group performs a 16-week stretching program. Feasibility of the HIIT intervention is measured by the number of exercise sessions completed, including total minutes and intensity, and barriers to exercise adherence. Cognition, physical fitness and function, HRQOL, and psychosocial health are measured using standardized assessments and self-report questionnaires. Exercise sustainability is measured by change in study outcomes following the self-directed follow-up period, and social determinants of health are assessed using a self-report questionnaire. RESULTS: Baseline data collection began in February 2024, and 13 participants have been enrolled as of June 2026. The projected study end date is December 2026. Data analysis is planned to begin in January 2027, and findings will be published in the fall of 2028. CONCLUSIONS: To our knowledge, this study is the first to use a virtually supervised HIIT intervention in young adult patients and survivors of brain tumor. The findings will elucidate the feasibility of HIIT to design and power a randomized controlled trial to address cancer- and treatment-related sequelae. They will also provide insights into the sustainability of HIIT and the impact of social determinants of health. CI - (c) Elizabeth Cox, Meghan Tahbaz, Ellaney Matarese, Rebekah L Wilson, L Nicolas Gonzalez Castro, Hajime Uno, Tabitha Cooney, Jordan Lane, Mary K Norris, Kira Bona, Rahela Aziz-Bose, Christina M Dieli-Conwright. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Cox, Elizabeth AU - Cox E AD - Department of Medicine, Harvard Medical School, Boston, MA, United States. FAU - Tahbaz, Meghan AU - Tahbaz M AD - Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States. FAU - Matarese, Ellaney AU - Matarese E AD - Department of Neuroscience, Harvard University, Cambridge, MA, United States. FAU - Wilson, Rebekah L AU - Wilson RL AUID- ORCID: 0000-0003-1704-3624 AD - Department of Medicine, Harvard Medical School, Boston, MA, United States. FAU - Gonzalez Castro, L Nicolas AU - Gonzalez Castro LN AUID- ORCID: 0000-0001-7699-5188 AD - Department of Neurology, Brigham and Women's Hospital/Mass General Brigham, Boston, MA, United States. AD - Center for Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, United States. FAU - Uno, Hajime AU - Uno H AUID- ORCID: 0000-0003-0622-8471 AD - Department of Medicine, Harvard Medical School, Boston, MA, United States. FAU - Cooney, Tabitha AU - Cooney T AUID- ORCID: 0000-0002-2614-020X AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, United States. FAU - Lane, Jordan AU - Lane J AUID- ORCID: 0009-0005-3399-0957 FAU - Norris, Mary K AU - Norris MK AUID- ORCID: 0000-0002-8914-1306 FAU - Bona, Kira AU - Bona K AUID- ORCID: 0000-0001-5602-7059 AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, United States. AD - Department of Pediatrics, Harvard Medical School, Boston, MA, United States. FAU - Aziz-Bose, Rahela AU - Aziz-Bose R AUID- ORCID: 0000-0003-4753-5144 AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, United States. AD - Department of Pediatrics, Harvard Medical School, Boston, MA, United States. FAU - Dieli-Conwright, Christina M AU - Dieli-Conwright CM AUID- ORCID: 0000-0001-9093-7259 AD - Department of Medicine, Harvard Medical School, Boston, MA, United States. AD - Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02215, United States, 1 617-582-8321. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20261015 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 RN - EC 1.1.1.41 (Isocitrate Dehydrogenase) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - *Brain Neoplasms/genetics/therapy/psychology MH - Feasibility Studies MH - *Glioma/genetics/therapy/psychology MH - *High-Intensity Interval Training/methods/standards MH - *Isocitrate Dehydrogenase/genetics MH - Mutation MH - Pilot Projects MH - Quality of Life MH - Randomized Controlled Trials as Topic PMC - PMC13671388 OTO - NOTNLM OT - AYA OT - HIIT OT - IDH mutant glioma OT - cognitive function OT - exercise oncology OT - high-intensity interval training OT - isocitrate dehydrogenase-mutant glioma OT - pediatric brain tumors COIS- Conflicts of Interest: None declared. EDAT- 2026/10/15 23:30 MHDA- 2026/10/15 23:31 PMCR- 2026/10/15 CRDT- 2026/10/15 19:01 PHST- 2025/12/01 00:00 [received] PHST- 2026/07/21 00:00 [revised] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/10/15 23:31 [medline] PHST- 2026/10/15 23:30 [pubmed] PHST- 2026/10/15 19:01 [entrez] PHST- 2026/10/15 00:00 [pmc-release] AID - v15i1e88718 [pii] AID - 88718 [pii] AID - 10.2196/88718 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Oct 15;15:e88718. doi: 10.2196/88718. PMID- 42879185 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261015 IS - 1365-277X (Electronic) IS - 0952-3871 (Linking) VI - 39 IP - 5 DP - 2026 Oct TI - Feasibility and Accuracy of Caregiver-Led Child Growth Measurements for Remote Healthcare. PG - e70364 LID - 10.1111/jhn.70364 [doi] AB - BACKGROUND AND AIMS: Remote healthcare is expanding, with accurate growth data essential for nutritional care. Guidance for routine caregiver-led measurements is limited and largely untested. This study evaluated the feasibility and accuracy of caregiver-led child growth measurements at home, compared to 'gold-standard' measurements in the hospital. METHODS: Caregivers of children attending outpatient appointments completed a survey on their access to weighing scales and tape measures at home. Those with suitable equipment were consented to participate in a home measurement study. Using provided instructions, caregivers measured their child twice within 48 h of a hospital appointment, where two healthcare professionals (HCPs) repeated measurements. Caregiver experiences were explored through short interviews. Agreement between methods was assessed using Bland-Altman analysis. RESULTS: Of 677 survey respondents (49% response), 61% owned both scales and tape measure, with ownership more likely in relatively affluent postcodes. One hundred and forty participants consented to the home measurement study but due to low recruitment in the 0-2-age group (n = 18), analysis was restricted to 122 2-15-year-olds with median age 8.5 [IQR 5,12]. Participants were predominantly white British (88%) from relatively affluent areas (78% IMD 5-10). LOA between caregivers and HCP were -3.46% to 3.79% (height) and -4.91% to 4.36% (weight), demonstrating reasonable caregiver accuracy. LOA between the two caregiver measurements were -0.97% to 0.99% (weight) and -1.04% to 0.80% (height), demonstrating consistency, and LOA between two HCPs were -0.48% to 0.53% (weight) and -0.61% to 0.55% (height), demonstrating good inter-observer agreement. The majority found the process straightforward, with greater confidence in weighing than in measuring, despite achieving lower accuracy. Most were willing to routinely provide measurements before remote appointments. CONCLUSIONS: Caregiver-led measurements appear feasible and reasonably accurate for children aged 2-15 years, although they may be more suitable to monitor trends, rather than in situations needing precision. Equipment access may be limited in less affluent areas, but generally, caregivers are willing to monitor weight and height at home. CI - (c) 2026 British Dietetic Association. FAU - Trace, Sarah L AU - Trace SL AUID- ORCID: 0000-0003-4408-1255 AD - Department of Nutrition and Dietetics, Bristol Hospitals NHS Foundation Trust, Bristol, UK. FAU - Leary, Sam D AU - Leary SD AUID- ORCID: 0000-0002-1706-0689 AD - Bristol Dental School, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK. FAU - Richards, Kara Y AU - Richards KY AUID- ORCID: 0009-0000-5917-6578 AD - Department of Nutrition and Dietetics, Bristol Hospitals NHS Foundation Trust, Bristol, UK. FAU - Shield, Julian P H AU - Shield JPH AUID- ORCID: 0000-0003-2601-7575 AD - NIHR Bristol Biomedical Research Centre, Diet and Physical Activity Theme, Faculty of Health and Life Sciences, University of Bristol, Bristol, UK. LA - eng GR - British Dietetic Association/ PT - Journal Article PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Humans MH - *Caregivers MH - Child MH - Child, Preschool MH - Adolescent MH - Female MH - Feasibility Studies MH - Male MH - Infant MH - *Child Development MH - Reproducibility of Results MH - Adult MH - Infant, Newborn OTO - NOTNLM OT - anthropometry OT - caregiver OT - child OT - growth OT - measurements OT - parent OT - remote EDAT- 2026/10/15 23:30 MHDA- 2026/10/15 23:31 CRDT- 2026/10/15 18:43 PHST- 2026/09/23 00:00 [revised] PHST- 2026/06/08 00:00 [received] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/15 23:31 [medline] PHST- 2026/10/15 23:30 [pubmed] PHST- 2026/10/15 18:43 [entrez] AID - 10.1111/jhn.70364 [doi] PST - ppublish SO - J Hum Nutr Diet. 2026 Oct;39(5):e70364. doi: 10.1111/jhn.70364. PMID- 42878537 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261027 IS - 1099-0496 (Electronic) IS - 1099-0496 (Linking) VI - 61 IP - 10 DP - 2026 Oct TI - Assessment of Cystic Fibrosis Lung Disease Using Electrical Impedance Tomography. PG - e71856 LID - e71856 [pii] LID - 10.1002/ppul.71856 [doi] AB - INTRODUCTION: Electrical impedance tomography (EIT) is a non-invasive, effort-independent imaging technique for measurement of regional lung ventilation and function that does not utilize ionizing radiation. There are limited data on the use of EIT to assess lung disease in people with CF (PwCF). METHODS: This was a cross-sectional observational cohort study. Study participants performed EIT, multiple breath washout (MBW) and spirometry in a single session. We analyzed EIT results to calculate the global inhomogeneity index (GII) and regional ventilation delay at 40% of maximal inspiratory impedance (RVD40). We used pairwise Spearman correlations to compare EIT measurements with the lung clearance index (LCI) and percent predicted forced expiratory volume in 1 s (FEV1pp). We generated receiver operator characteristic (ROC) curves to assess specificity and sensitivity for GII and RVD40 to predict an abnormal LCI. RESULTS: 31 participants ranging in age from 6 to 65 years performed EIT and spirometry; 23 performed research-quality MBW. The median GII and RVD40 were 39.1 and 5.52, respectively. The median LCI was 8.9. RVD40 correlated moderately with LCI (r = 0.49, p = 0.02) and negatively correlated with FEV1pp (r = -0.36, p = 0.04). There was a weak positive correlation between GII and LCI (r = 0.27, p = 0.21). GII demonstrated a significant negative correlation with FEV1pp (r = -0.44, p = 0.01). DISCUSSION: We found that EIT measurements correlated with spirometry and MBW. RVD40 was more sensitive and specific for ventilation inhomogeneity as compared to GII. Our data suggest that EIT measurements made during tidal breathing could be a useful clinical test in the evaluation of CF lung disease, though further investigations are needed. CI - (c) 2026 Wiley Periodicals LLC. FAU - Boas, Heather AU - Boas H AUID- ORCID: 0009-0003-1874-303X AD - Section of Pediatric Pulmonology, Dartmouth Health Children's, Lebanon, New Hampshire, USA. AD - Department of Pediatrics, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA. FAU - Bennett, Laura AU - Bennett L AD - Biostatistics and Data Management Core, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Faerber, Jennifer AU - Faerber J AD - Biostatistics and Data Management Core, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Donnelly, Erin C AU - Donnelly EC AD - Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Gari, Matthew AU - Gari M AD - Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Sailman, Gina E AU - Sailman GE AD - Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Pierdomenico, Alyssa AU - Pierdomenico A AD - Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Napolitano, Natalie AU - Napolitano N AUID- ORCID: 0000-0002-1498-8465 AD - Respiratory Therapy Department, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Dorgan, Daniel AU - Dorgan D AD - Department of Pulmonary Medicine, Penn Medicine, Philadelphia, Pennsylvania, USA. AD - Department of Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. FAU - Panitch, Howard B AU - Panitch HB AUID- ORCID: 0000-0001-8440-283X AD - Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. AD - Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. FAU - Ren, Clement L AU - Ren CL AUID- ORCID: 0000-0003-4431-0644 AD - Division of Pulmonary and Sleep Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. AD - Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. LA - eng GR - BOAS23D0/Cystic Fibrosis Foundation/ PT - Journal Article PT - Observational Study PL - United States TA - Pediatr Pulmonol JT - Pediatric pulmonology JID - 8510590 SB - IM MH - Humans MH - *Cystic Fibrosis/physiopathology/diagnostic imaging MH - *Electric Impedance MH - Cross-Sectional Studies MH - Female MH - Male MH - Adolescent MH - Adult MH - *Tomography/methods MH - Middle Aged MH - Child MH - Spirometry MH - Young Adult MH - Aged MH - Respiratory Function Tests MH - Forced Expiratory Volume MH - ROC Curve MH - *Lung/physiopathology/diagnostic imaging MH - Sensitivity and Specificity OTO - NOTNLM OT - bioelectrical impedance OT - lung clearance index OT - lung imaging OT - pulmonary function test OT - ventilation inhomogeneity EDAT- 2026/10/15 23:30 MHDA- 2026/10/15 23:31 CRDT- 2026/10/15 17:21 PHST- 2026/09/06 00:00 [revised] PHST- 2025/12/01 00:00 [received] PHST- 2026/09/26 00:00 [accepted] PHST- 2026/10/15 23:31 [medline] PHST- 2026/10/15 23:30 [pubmed] PHST- 2026/10/15 17:21 [entrez] AID - e71856 [pii] AID - 10.1002/ppul.71856 [doi] PST - ppublish SO - Pediatr Pulmonol. 2026 Oct;61(10):e71856. doi: 10.1002/ppul.71856. PMID- 42876603 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261015 LR - 20261016 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Socio-demographic and community-level determinants of delayed breastfeeding initiation in Borama, Somalia: a multilevel mixed-effects analysis. PG - 1945737 LID - 10.3389/fnut.2026.1945737 [doi] LID - 1945737 AB - BACKGROUND: Timely initiation of breastfeeding is a proven life-saving intervention for reducing neonatal morbidity and mortality. Despite global advocacy, adherence in fragile health systems remains critically low. This study assesses the magnitude and multi-level epidemiological predictors of delayed breastfeeding initiation among postnatal mothers in Borama, Somalia. METHODS: An institution-based cross-sectional study was conducted among 392 postnatal mothers (aged 15-49 years) recruited via systematic random sampling at the Sheekh Osman Center for Community Health. Data were gathered using a pre-tested, structured interviewer-administered questionnaire. Delayed breastfeeding initiation was defined as initiating suckling more than 30 min postpartum. Participants were nested within 14 recognized municipal neighborhood clusters in Borama. To account for community-level clustering, a four-step hierarchical multilevel mixed-effects logistic regression was performed. Fixed effects were expressed as Adjusted Odds Ratios (aOR) with 95% Confidence Intervals (CI), and random effects were quantified using the Intraclass Correlation Coefficient (ICC). RESULTS: The magnitude of delayed breastfeeding initiation was 40.8% (95% CI: 35.9-45.8%; n = 160 ). In bivariate analysis, delayed initiation was significantly associated with maternal education level ( p < 0.001 ) and absence of antenatal breastfeeding information ( p < 0.001 ). In the final fully adjusted multilevel model, the absence of breastfeeding counseling during antenatal care was the strongest independent predictor of delay (aOR = 7.93, 95% CI: 4.51-13.95, p < 0.001 ). Mothers without formal education had three-fold higher odds of delayed initiation compared to college-educated mothers (aOR = 3.07, 95% CI: 1.33-7.07, p = 0.008 ). Mothers aged 15-20 years had lower odds of delay compared to those older than 30 years (aOR = 0.39, 95% CI: 0.18-0.87, p = 0.021 ). The null model demonstrated significant community clustering (ICC = 18.1%, p < 0.001 ), which increased to 25.6% in the final adjusted model. CONCLUSION: Over four in ten mothers experienced delayed breastfeeding initiation. Gaps in antenatal counseling, lack of maternal formal education, and neighborhood-level clustering are primary drivers of delayed initiation. Health authorities must implement facility-based Baby-Friendly Hospital Initiative protocols and intensify antenatal lactation counseling. CI - Copyright (c) 2026 Hared, Omer Ali, Hassan, Ahmed, Abdi, Abdulahi and Nadarajah. FAU - Hared, Yusuf Abdi AU - Hared YA AD - Center for Community Services, Amoud University, Borama, Somalia. AD - School of Health and Welfare, Dalarna University, Falun, Sweden. FAU - Omer Ali, Abdirahman AU - Omer Ali A AD - Center for Community Services, Amoud University, Borama, Somalia. AD - College of Health Sciences, Amoud University, Borama, Somalia. FAU - Hassan, Abdisalam Mahdi AU - Hassan AM AD - Center for Community Services, Amoud University, Borama, Somalia. AD - College of Health Sciences, Amoud University, Borama, Somalia. FAU - Ahmed, Hodan Saed AU - Ahmed HS AD - Center for Community Services, Amoud University, Borama, Somalia. AD - College of Health Sciences, Amoud University, Borama, Somalia. FAU - Abdi, Muhiadin Ismail AU - Abdi MI AD - Center for Community Services, Amoud University, Borama, Somalia. AD - College of Health Sciences, Amoud University, Borama, Somalia. FAU - Abdulahi, Hodo Abdi AU - Abdulahi HA AD - Center for Community Services, Amoud University, Borama, Somalia. FAU - Nadarajah, Saralees AU - Nadarajah S AD - Department of Mathematics, University of Manchester, Manchester, United Kingdom. LA - eng PT - Journal Article DEP - 20260930 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13661310 OTO - NOTNLM OT - Somalia OT - exclusive breastfeeding OT - infant nutrition OT - multilevel analysis OT - risk factors COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/15 13:35 MHDA- 2026/10/15 13:36 PMCR- 2026/09/30 CRDT- 2026/10/15 07:02 PHST- 2026/07/22 00:00 [received] PHST- 2026/09/07 00:00 [revised] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/10/15 13:36 [medline] PHST- 2026/10/15 13:35 [pubmed] PHST- 2026/10/15 07:02 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - 10.3389/fnut.2026.1945737 [doi] PST - epublish SO - Front Nutr. 2026 Sep 30;13:1945737. doi: 10.3389/fnut.2026.1945737. eCollection 2026. PMID- 42876325 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261019 IS - 1654-9880 (Electronic) IS - 1654-9716 (Print) IS - 1654-9880 (Linking) VI - 19 IP - 1 DP - 2026 Dec TI - Predicting neurodevelopmental delay among two-year-old infants in Northern Uganda. PG - 2748101 LID - 10.1080/16549716.2026.2748101 [doi] LID - 2748101 AB - BACKGROUND: Data on neurodevelopmental disabilities in sub-Saharan Africa are scarce. Identifying children at the highest risk of neurodevelopmental delay could enable health workers to target these groups more effectively, improve resource allocation and programmatic focus. OBJECTIVE: To develop and assess a model for predicting neurodevelopmental delay among two-year-old infants in Northern Uganda using easily obtainable predictors. METHODS: We studied children born to women enrolled in a cluster randomized controlled trial (January 2018-March 2019) evaluating the effect of peer counseling on health facility births. At the trial's final visit (day 50), 1,804 children were enrolled. In November 2020, we followed up 1,421 children (78.8%) and assessed their neurodevelopment at 2 years using the Malawi Developmental Assessment Tool. We used least absolute shrinkage and selection operator penalized regression with 10-fold cross-validation to select the best subset of predictors and assessed model performance using the area under the curve (AUC). RESULTS: Of the 1,421 children, 70 (4.9%; 95% CI: 3.6-6.7%) had neurodevelopmental delays. Of the 19 candidate predictors, six were retained in the final model (lambda = 0.0076): moderate wasting, prolonged neonatal hospitalization (up to 28 days), maternal education, place of birth, preterm birth, and absence of skin-to-skin contact at birth. The model showed strong discriminative power (AUC 0.75) and reasonable calibration (calibration slope 1.37; calibration belt 0.536-0.727). CONCLUSION: We developed a promising tool for identifying infants at increased risk of neurodevelopmental delay in low-resource settings, which could help prioritize children for follow-up and specialized interventions. FAU - Mukunya, David AU - Mukunya D AUID- ORCID: 0000-0002-3892-9777 AD - Department of Community and Public Health, Busitema University, Mbale, Uganda. AD - Department of Research, Nikao Medical Center, Kampala, Uganda. FAU - Ndeezi, Grace AU - Ndeezi G AD - Department of Paediatrics and Child Health, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda. FAU - Namazzi, Gertrude AU - Namazzi G AD - Department of Paediatrics and Child Health, School of Medicine, Makerere University College of Health Sciences, Kampala, Uganda. AD - Department of Health Policy, Planning and Management, School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda. FAU - Tylleskar, Thorkild AU - Tylleskar T AUID- ORCID: 0000-0003-4801-4324 AD - Center for Internation Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. FAU - Nambozo, Brendah AU - Nambozo B AUID- ORCID: 0009-0002-8600-8654 AD - Department of Community and Public Health, Busitema University, Mbale, Uganda. AD - Center for Internation Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. FAU - Musaba, Milton W AU - Musaba MW AD - Department of Obstetrics and Gynaecology, Busitema University Faculty of Health Sciences, Mbale, Uganda. FAU - Odongkara, Beatrice AU - Odongkara B AD - Department of Paediatrics and Child Health, Gulu University, Gulu, Uganda. FAU - Achora, Vincentina AU - Achora V AD - Department of Obstetrics and Gynaecology, Gulu University, Gulu, Uganda. FAU - Tongun, Justin Bruno AU - Tongun JB AD - Department of Paediatrics and Child Health, University of Juba, Juba, South Sudan. FAU - Tumuhamye, Josephine AU - Tumuhamye J AUID- ORCID: 0000-0001-5451-6406 AD - Department of Research, Makerere University Hospital, Kampala, Uganda. FAU - Napyo, Agnes AU - Napyo A AUID- ORCID: 0000-0003-4333-3588 AD - Department of Nursing, School of Medicine, Kabale University, Kabale, Uganda. FAU - Ssentumbwe, Vicent AU - Ssentumbwe V AD - Division of Computational and Data Science, Washington University in St. Louis, St. Louis, MO, USA. FAU - Nankabirwa, Victoria AU - Nankabirwa V AD - Centre for Intervention Science and Maternal Child Health (CISMAC), Centre for International Health, University of Bergen, Bergen, Norway. AD - Department of Epidemiology and Biostatistics, School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda. FAU - Tumwine, James K AU - Tumwine JK AD - Department of Paediatrics and Child Health, Kabale University, Kabale, Uganda. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20261015 PL - United States TA - Glob Health Action JT - Global health action JID - 101496665 SB - IM MH - Humans MH - Uganda/epidemiology MH - Female MH - Male MH - Child, Preschool MH - *Developmental Disabilities/epidemiology/diagnosis MH - *Neurodevelopmental Disorders/epidemiology MH - Risk Factors MH - Infant PMC - PMC13674651 OAB - Main findings: we developed and evaluated a risk prediction model that identified six readily available factors associated with neurodevelopmental delay among infants in Northern Uganda and demonstrated a good ability to distinguish children at increased risk.Added knowledge: this study provides evidence that routinely collected maternal, birth, and early infant characteristics can be used to support early identification of children who may benefit from targeted neurodevelopmental follow-up.Global health impact for policy and action: the findings provide a practical approach for low-resource settings to improve early detection, prioritize limited resources, and guide interventions to reduce the burden of neurodevelopmental disabilities. OABL- eng OTO - NOTNLM OT - Early child development; thriving OT - human capacity development OT - human capital OT - low-income countries OT - neurodevelopmental delay OT - risk stratification COIS- No potential conflict of interest was reported by the author(s). EDAT- 2026/10/15 07:18 MHDA- 2026/10/15 07:19 PMCR- 2026/10/15 CRDT- 2026/10/15 03:53 PHST- 2026/10/15 07:19 [medline] PHST- 2026/10/15 07:18 [pubmed] PHST- 2026/10/15 03:53 [entrez] PHST- 2026/10/15 00:00 [pmc-release] AID - 2748101 [pii] AID - 10.1080/16549716.2026.2748101 [doi] PST - ppublish SO - Glob Health Action. 2026 Dec;19(1):2748101. doi: 10.1080/16549716.2026.2748101. Epub 2026 Oct 15. PMID- 42876122 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261015 IS - 0004-0614 (Print) IS - 0004-0614 (Linking) VI - 79 IP - 8 DP - 2026 Sep TI - Early Postoperative Testicular Volume Ratio Is Associated With Long-Term Growth Failure After Unilateral Redo Orchiopexy in Children. PG - 1311-1320 LID - 10.56434/j.arch.esp.urol.aeu039 [doi] AB - BACKGROUND: Redo orchiopexy is usually evaluated based on the position of the scrotum after surgery, but satisfactory scrotal placement may not necessarily reflect preserved long-term testicular growth. In this study, we evaluated whether the early postoperative testicular volume ratio (TVR) is associated with long-term growth failure after unilateral redo orchiopexy in children. METHODS: This retrospective single-center cohort study included children who underwent unilateral redo orchiopexy between January 2013 and January 2023. Early postoperative ultrasonography was performed 6-12 months after surgery, and subsequent follow-up ultrasonography was performed at >/=24 months. TVR was calculated as the operated testicular volume divided by the contralateral testicular volume x 100. Long-term growth failure was defined as long-term TVR <50% and/or the absence of an interval increase in operated testicular volume beyond expected ultrasonographic measurement variability. The discriminative ability of early TVR was assessed using receiver operating characteristic (ROC) analysis. The ROC-derived cutoff was considered exploratory because it was derived and evaluated in the same cohort. RESULTS: Sixty-eight children met the inclusion criteria. The mean age at redo orchiopexy was 7.8 +/- 2.9 years, and the median follow-up was 36 months. Long-term growth failure occurred in 20 patients (29.4%). Children with growth failure had significantly lower early TVR than those with preserved growth (48.6 +/- 13.2% vs. 80.4 +/- 16.8%, p < 0.001). Early TVR showed good apparent discrimination, with an area under the curve (AUC) of 0.84 (95% confidence interval [CI], 0.72-0.96). In the exploratory multivariable model, each 10-percentage-point increase in early TVR was associated with a lower odds of growth failure (odds ratio [OR] 0.56; 95% bootstrap CI 0.36-0.84). The apparent model AUC was 0.86, and the optimism-corrected AUC after 1000 bootstrap resamples was 0.81. The exploratory 55% cutoff yielded 82% sensitivity, 78% specificity, 69% positive predictive value, and 88% negative predictive value. CONCLUSIONS: Early postoperative TVR is associated with long-term testicular growth failure after unilateral redo orchiopexy. A TVR of approximately 55% may help identify children who require closer ultrasonographic surveillance, but this threshold is hypothesis-generating and requires external validation before clinical implementation. TVR should be interpreted as an imaging-based risk stratification marker rather than a direct measure of endocrine, fertility, or histologic testicular function. CI - (c) 2026 The Author(s). FAU - Baltrak, Yusuf Atakan AU - Baltrak YA AD - Department of Pediatric Urology, Adana City Education and Research Hospital, 01370 Adana, Turkiye. FAU - Turker Colak, Selcan AU - Turker Colak S AD - Department of Pediatric Surgery, Faculty of Medicine, Cukurova University, 01330 Adana, Turkiye. FAU - Tutus, Kamuran AU - Tutus K AD - Department of Pediatric Surgery, Faculty of Medicine, Cukurova University, 01330 Adana, Turkiye. FAU - Kilic, Seref Selcuk AU - Kilic SS AD - Department of Pediatric Surgery, Faculty of Medicine, Cukurova University, 01330 Adana, Turkiye. FAU - Ozden, Onder AU - Ozden O AD - Department of Pediatric Surgery, Faculty of Medicine, Cukurova University, 01330 Adana, Turkiye. FAU - Alkan, Murat AU - Alkan M AD - Department of Pediatric Surgery, Faculty of Medicine, Cukurova University, 01330 Adana, Turkiye. FAU - Tuncer, Recep AU - Tuncer R AD - Department of Pediatric Surgery, Faculty of Medicine, Cukurova University, 01330 Adana, Turkiye. LA - eng PT - Journal Article PL - Spain TA - Arch Esp Urol JT - Archivos espanoles de urologia JID - 0064757 SB - IM MH - Humans MH - Male MH - *Orchiopexy/adverse effects/methods MH - Retrospective Studies MH - Organ Size MH - *Testis/growth & development/diagnostic imaging/pathology/anatomy & histology MH - Reoperation MH - Child, Preschool MH - *Cryptorchidism/surgery MH - Time Factors MH - Ultrasonography MH - Cohort Studies OTO - NOTNLM OT - cryptorchidism OT - redo orchiopexy OT - testicular growth failure OT - testicular volume ratio OT - ultrasonography COIS- All authors have completed the ICMJE uniform disclosure form. The authors have no conflicts of interest to declare. A preprint version of this study was previously posted online under the title "Early Testicular Volume Ratio Predicts Growth Failure after Redo Orchiopexy in Children" (DOI: 10.21203/rs.3.rs-9876005/v1; URL: https://doi.org/10.21203/rs.3.rs-9876005/v1. EDAT- 2026/10/15 07:18 MHDA- 2026/10/15 07:19 CRDT- 2026/10/15 02:13 PHST- 2026/10/15 07:19 [medline] PHST- 2026/10/15 07:18 [pubmed] PHST- 2026/10/15 02:13 [entrez] AID - 10.56434/j.arch.esp.urol.aeu039 [doi] PST - ppublish SO - Arch Esp Urol. 2026 Sep;79(8):1311-1320. doi: 10.56434/j.arch.esp.urol.aeu039. PMID- 42876010 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261023 IS - 1643-3750 (Electronic) IS - 1234-1010 (Print) IS - 1234-1010 (Linking) VI - 32 DP - 2026 Oct 15 TI - Validation of the Children and Adolescents Physical Activity and Sedentary Questionnaire (CAPAS-Q) in Polish Children and Adolescents. PG - e953567 LID - 10.12659/MSM.953567 [doi] LID - e953567 AB - BACKGROUND Global public health faces challenges related to low physical activity (PA) and excessive sedentary behavior (SB) among youth. This study aimed to validate the Polish version of the Children and Adolescents Physical Activity and Sedentary Questionnaire (CAPAS-Q). MATERIAL AND METHODS The study involved 206 participants (114 girls, 92 boys) aged 8 to 17 years. Participants completed the CAPAS-Q twice (7-day interval) to assess test-retest reliability. Objective PA and SB data were collected concurrently using ActiGraph wGT3X-BT accelerometers. Psychometric evaluation included internal consistency (Cronbach's alpha), test-retest reliability (intraclass correlation coefficient [ICC]), and criterion validity (Spearman's rank correlation [rs]). RESULTS Internal consistency was acceptable (Cronbach's alpha 0.674 for PA and 0.754 for SB). Test-retest reliability was good to excellent, with subscale ICCs of 0.7429 to 0.9375. For criterion validity, the SB dimension showed moderate correlations with accelerometer-derived total PA (rs=-0.41) and sedentary time (rs=0.41). PA subscale correlations were generally smaller, with the highest association found between sports/leisure PA and moderate to vigorous PA (rs=0.27). Psychometric properties varied by group, with lower PA validity in younger children and adolescent girls. CONCLUSIONS The Polish CAPAS-Q demonstrates good to excellent test-retest reliability, although its internal consistency varies across subgroups, being lower in younger children. While the tool shows moderate criterion validity for SBs, its validity for quantifying PA volume is weak. Nevertheless, the CAPAS-Q provides valuable contextual and qualitative data. It is recommended as a cost-effective instrument for contextual screening in epidemiological studies, but caution is advised when interpreting PA levels in younger children and adolescent girls. FAU - Baran, Rafal AU - Baran R AUID- ORCID: 0000-0001-9638-9505 AD - Faculty of Health Sciences and Psychology, Institute of Physiotherapy, University of Rzeszow, Rzeszow, Poland. FAU - Baran, Joanna AU - Baran J AUID- ORCID: 0000-0001-8354-1651 AD - Faculty of Health Sciences and Psychology, Institute of Physiotherapy, University of Rzeszow, Rzeszow, Poland. FAU - Leszczak, Justyna AU - Leszczak J AUID- ORCID: 0000-0001-8769-0048 AD - Faculty of Health Sciences and Psychology, Institute of Physiotherapy, University of Rzeszow, Rzeszow, Poland. FAU - Fillon, Alicia AU - Fillon A AUID- ORCID: 0000-0002-0614-8909 AD - Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), EA 3533, Clermont Auvergne University, CRNH Auvergne, Clermont-Ferrand, France. AD - National Observatory for Physical Activity and Sedentary Behaviors (ONAPS), UFR Medicine, University Clermont Auvergne, Clermont-Ferrand, France. FAU - Thivel, David AU - Thivel D AUID- ORCID: 0000-0003-4687-3555 AD - Laboratory of the Metabolic Adaptations to Exercise under Physiological and Pathological Conditions (AME2P), EA 3533, Clermont Auvergne University, CRNH Auvergne, Clermont-Ferrand, France. AD - National Observatory for Physical Activity and Sedentary Behaviors (ONAPS), UFR Medicine, University Clermont Auvergne, Clermont-Ferrand, France. FAU - Wyszynska, Justyna AU - Wyszynska J AUID- ORCID: 0000-0002-5786-6214 AD - Faculty of Health Sciences and Psychology, Institute of Physiotherapy, University of Rzeszow, Rzeszow, Poland. LA - eng PT - Journal Article PT - Validation Study DEP - 20261015 PL - United States TA - Med Sci Monit JT - Medical science monitor : international medical journal of experimental and clinical research JID - 9609063 SB - IM MH - Humans MH - Child MH - Female MH - Adolescent MH - *Sedentary Behavior MH - Poland MH - Surveys and Questionnaires MH - *Exercise/physiology/psychology MH - Male MH - Reproducibility of Results MH - Psychometrics/methods MH - Accelerometry/methods PMC - PMC13685572 COIS- Conflict of interest: None declared EDAT- 2026/10/15 07:18 MHDA- 2026/10/15 07:19 PMCR- 2026/10/15 CRDT- 2026/10/15 01:22 PHST- 2026/10/15 07:19 [medline] PHST- 2026/10/15 07:18 [pubmed] PHST- 2026/10/15 01:22 [entrez] PHST- 2026/10/15 00:00 [pmc-release] AID - 953567 [pii] AID - 10.12659/MSM.953567 [doi] PST - epublish SO - Med Sci Monit. 2026 Oct 15;32:e953567. doi: 10.12659/MSM.953567. PMID- 42875715 OWN - NLM STAT- Publisher LR - 20261014 IS - 1543-0154 (Electronic) IS - 0885-8195 (Linking) DP - 2026 Oct 15 TI - Integrating Physical Activity and Family Health Education into Pediatric Oncology Outpatient Care: ATIVAONCO Project. LID - 10.1007/s13187-026-02999-7 [doi] AB - ATIVAONCO is a university extension project designed to integrate adapted physical activity and family health education into routine pediatric oncology outpatient care in a public hospital in southern Brazil. This descriptive experience report summarizes the program's implementation from 2023 onward. Activities are offered twice weekly during a two-hour outpatient window and are delivered by exercise professionals and supervised trainees. Each session combines a brief health-education component for parents and caregivers, playful and adaptable movement activities for children and adolescents, and a closing discussion circle. Program monitoring uses team observations, participant and caregiver feedback, and session records to support iterative adaptation. Over the years, more than 300 children and adolescents participated in the project, with a mean age of 7.53 +/- 3.30 years; 53.2% were male and 46.8% were female. Recurring observations included engagement with movement activities, social interaction, and use of the waiting area as a more active and welcoming space. ATIVAONCO project demonstrates the practical feasibility of embedding physical activity promotion and family-centered education into outpatient pediatric oncology care. Future evaluations should measure educational outcomes, physical activity exposure, patient-reported outcomes, and safety using standardized prospective methods. CI - (c) 2026. The Author(s). FAU - Carminatti, Micheli AU - Carminatti M AUID- ORCID: 0000-0001-8926-8211 AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Cappellaro, Erica AU - Cappellaro E AUID- ORCID: 0009-0006-7907-1427 AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Benitez, Herber Orlando AU - Benitez HO AUID- ORCID: 0009-0009-6891-3598 AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Wolin, Ingrid Alessandra Victoria AU - Wolin IAV AUID- ORCID: 0000-0002-2156-0715 AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. ingridwolin@gmail.com. FAU - Lana, Isadora Dalla AU - Lana ID AUID- ORCID: 0009-0009-5122-5326 AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Mohamed, Gustavo Vieira AU - Mohamed GV AUID- ORCID: 0009-0006-8126-6485 AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Ramos, Julia de Lima AU - Ramos JL AUID- ORCID: 0009-0000-2007-147X AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Delevatti, Rodrigo Sudatti AU - Delevatti RS AUID- ORCID: 0000-0003-1827-7799 AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Gerage, Aline Mendes AU - Gerage AM AUID- ORCID: 0000-0002-0555-5422 AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Freitas, Cintia de la Rocha AU - Freitas CR AUID- ORCID: 0000-0001-8566-6298 AD - Federal University of Santa Catarina, Florianopolis, SC, Brazil. LA - eng PT - Journal Article DEP - 20261015 PL - England TA - J Cancer Educ JT - Journal of cancer education : the official journal of the American Association for Cancer Education JID - 8610343 SB - IM OTO - NOTNLM OT - Cancer education OT - Family-centered care OT - Health education OT - Pediatric oncology OT - Physical activity OT - Supportive care COIS- Declarations. Ethical approval: The ATIVAONCO Project was approved by the Human Research Ethics Committee of the Federal University of Santa Catarina (Approval No. 6,663,135) and by the Human Research Ethics Committee of the Joana de Gusmao Children's Hospital (Approval No. 6,946,800). All procedures were conducted in accordance with the ethical principles applicable to research involving human participants Consent to participate: Written informed consent was obtained from the parents or legal guardians of participating children and adolescents, and assent was obtained from the participants when applicable, according to age and capacity for understanding and in accordance with the procedures approved by the Research Ethics Committees. Consent to publish: Not applicable. The manuscript does not contain identifiable individual participant data, images, or other information requiring consent for publication. Relevance to cancer education: ATIVAONCO integrates family-centered education on physical activity and healthy behaviors into routine pediatric oncology outpatient care while providing a supervised practice setting for exercise-science trainees. This report describes the implementation of a cancer-care education strategy at patient-family and trainee levels; educational learning outcomes were not formally measured. Competing interests: The authors declare that they have no financial or non-financial competing interests relevant to the content of this article. EDAT- 2026/10/15 07:18 MHDA- 2026/10/15 07:18 CRDT- 2026/10/14 23:55 PHST- 2026/09/10 00:00 [received] PHST- 2026/10/02 00:00 [accepted] PHST- 2026/10/15 07:18 [medline] PHST- 2026/10/15 07:18 [pubmed] PHST- 2026/10/14 23:55 [entrez] AID - 10.1007/s13187-026-02999-7 [pii] AID - 10.1007/s13187-026-02999-7 [doi] PST - aheadofprint SO - J Cancer Educ. 2026 Oct 15. doi: 10.1007/s13187-026-02999-7. PMID- 42875372 OWN - NLM STAT- Publisher LR - 20261014 IS - 1098-108X (Electronic) IS - 0276-3478 (Linking) DP - 2026 Oct 14 TI - Integrating Family-Based Treatment Components Into CBT-E for Adolescent Eating Disorders: A Narrative Review and Proposal for Family-Enhanced CBT-E (CBT-FE). LID - 10.1002/eat.70239 [doi] AB - OBJECTIVE: Family-based treatment (FBT) and Enhanced Cognitive Behavior Therapy (CBT-E) are two leading evidence-based outpatient approaches for adolescent eating disorders, but their strengths and limitations may be partly complementary. This review critically examines both approaches and proposes a structured integration termed Family-Enhanced CBT-E (CBT-FE). METHOD: The theoretical foundations, treatment structures, evidence base, and limitations of FBT and adolescent CBT-E were narratively reviewed, with particular attention to parental involvement, cognitive maintaining mechanisms, weight restoration, treatment engagement, and developmental considerations. RESULTS: CBT-FE retains the four-phase structure, personalized formulation, and core intervention strategies of CBT-E as the treatment backbone while incorporating formulation-driven parent and family components adapted from FBT. These include a non-blaming stance, externalization, parental empowerment, structured meal support, and gradual transfer of responsibility for eating. Parental involvement is conceptualized as a flexible "dose" calibrated according to the adolescent's age, insight, weight status, clinical needs, and family capacity, and progressively reduced as treatment advances. DISCUSSION: CBT-FE does not alter the first-line status of family therapy: it is intended for adolescents in whom individual treatment is indicated or chosen and structures family involvement within that treatment from the start. It is a conceptual proposal intended to preserve adolescent agency and CBT-E's direct targeting of maintaining mechanisms while mobilizing family resources when clinically indicated. Its feasibility, acceptability, and effectiveness require prospective evaluation in open trials and randomized controlled studies. CI - (c) 2026 The Author(s). International Journal of Eating Disorders published by Wiley Periodicals LLC. FAU - Ogutlu, Hakan AU - Ogutlu H AUID- ORCID: 0000-0002-1325-446X AD - Department of Child and Adolescent Psychiatry, University College Dublin, Dublin, Ireland. AD - Department of Child and Adolescent Psychiatry, Cognitive Behavioral Psychotherapies Association, Ankara, Turkey. FAU - Cepni, Simay AU - Cepni S AUID- ORCID: 0009-0007-7588-3871 AD - Private Practice, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20261014 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM OTO - NOTNLM OT - adolescent OT - anorexia nervosa OT - cognitive behavioral therapy OT - eating disorders OT - family-based treatment OT - treatment integration EDAT- 2026/10/14 23:32 MHDA- 2026/10/14 23:32 CRDT- 2026/10/14 22:12 PHST- 2026/09/29 00:00 [revised] PHST- 2026/08/17 00:00 [received] PHST- 2026/10/05 00:00 [accepted] PHST- 2026/10/14 23:32 [medline] PHST- 2026/10/14 23:32 [pubmed] PHST- 2026/10/14 22:12 [entrez] AID - 10.1002/eat.70239 [doi] PST - aheadofprint SO - Int J Eat Disord. 2026 Oct 14. doi: 10.1002/eat.70239. PMID- 42874221 OWN - NLM STAT- Publisher LR - 20261014 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 206 DP - 2026 Oct 9 TI - Quantitative ultrasound-derived estimated fat fraction for detection and grading of metabolic dysfunction-associated steatotic liver disease in a pediatric population. PG - 113294 LID - S0720-048X(26)00642-X [pii] LID - 10.1016/j.ejrad.2026.113294 [doi] AB - BACKGROUND: Pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) prevalence is approximately 10%, but ultrasound fat quantification lacks validation. This study evaluated the diagnostic performance of quantitative ultrasound-derived estimated fat fraction (USFF) against magnetic resonance imaging proton density fat fraction (MRI-PDFF) in children with suspected MASLD. METHODS: This prospective single-center study enrolled 65 children aged 6-18 years with suspected MASLD. USFF, tissue attenuation imaging (TAI), tissue scatter distribution imaging (TSI), hepato-renal index (EzHRI), and shear wave elastography (SWE) were measured on a Samsung R10 Prestige platform; 3.0 T MRI-PDFF served as reference. Steatosis was graded using pediatric PDFF thresholds. Diagnostic performance was assessed by ROC analysis with DeLong comparisons and internally validated by bootstrap resampling; agreement by Bland-Altman analysis; inter-operator reproducibility assessed in a randomly selected 30-child subset. RESULTS: Among 65 children (48 boys; median age 11.2 years), 20 were classified as S0, 29 as S1, and 16 as S2-3. USFF AUCs were 0.941 (>/=S1) and 0.960 (>/=S2), higher than EzHRI and SWE, and similar to TAI (0.903, 0.957) and TSI (0.900, 0.880). USFF strongly correlated with MRI-PDFF (rho = 0.906) but systematically underestimated PDFF (mean bias - 3.13%; non-parametric limits of agreement - 14.51% to + 4.24%). In an exploratory analysis, younger children (<12 years) showed larger bias (-4.00% vs - 1.82%, p = 0.029) with similar AUC point estimates. CONCLUSIONS: USFF shows high diagnostic performance (AUC > 0.94) for pediatric MASLD, but its 3.13% underestimation and wide non-parametric limits of agreement warrant caution. USFF may serve as a practical tool for categorical steatosis grading in children with suspected MASLD, and the proposed thresholds require external validation before clinical use. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Wang, Yujue AU - Wang Y AD - Department of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Du, Lanxin AU - Du L AD - Department of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Yang, Caiwei AU - Yang C AD - Department of Radiology, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Wang, Qian AU - Wang Q AD - Department of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Pang, Houqing AU - Pang H AD - Department of Ultrasound, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. Electronic address: panghouqing75@163.com. FAU - Li, Ping AU - Li P AD - Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, NHC Key Laboratory of Chronobiology, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China. Electronic address: pingli_0415@scu.edu.cn. LA - eng PT - Journal Article DEP - 20261009 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 SB - IM OTO - NOTNLM OT - Adiposity OT - MASLD OT - Magnetic resonance imaging OT - Pediatric OT - Quantitative ultrasound OT - Ultrasonography COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/14 23:32 MHDA- 2026/10/14 23:32 CRDT- 2026/10/14 18:05 PHST- 2026/08/05 00:00 [received] PHST- 2026/09/17 00:00 [revised] PHST- 2026/10/08 00:00 [accepted] PHST- 2026/10/14 23:32 [medline] PHST- 2026/10/14 23:32 [pubmed] PHST- 2026/10/14 18:05 [entrez] AID - S0720-048X(26)00642-X [pii] AID - 10.1016/j.ejrad.2026.113294 [doi] PST - aheadofprint SO - Eur J Radiol. 2026 Oct 9;206:113294. doi: 10.1016/j.ejrad.2026.113294. PMID- 42873276 OWN - NLM STAT- Publisher LR - 20261014 IS - 1432-198X (Electronic) IS - 0931-041X (Linking) DP - 2026 Oct 14 TI - Feasibility and acceptability of a telehealth-supported physical activity program for children with chronic kidney disease: a pilot mixed methods study. LID - 10.1007/s00467-026-07560-8 [doi] AB - BACKGROUND: Children with chronic kidney disease (CKD) often experience high levels of physical inactivity, exacerbating their health challenges and diminishing their quality of life. Given the potential health risks and reported barriers to sustained engagement in physical activity interventions, our objective was to evaluate the feasibility and acceptability of an individualized telehealth-supported physical activity program for adolescents with CKD stages 2-5. METHODS: This study was a 2-arm randomized waitlist control intervention to evaluate a 12-week telehealth physical activity program in children with CKD. Eligible participants, aged 11-18 years with CKD stages 2-5, were randomized via permuted block randomization, with CKD stage and sex as stratification factors, into a waitlist control (WLC) or physical activity intervention group. The treatment group received every 2-weeks video visits and personalized physical activity plans to increase or maintain >/=150 min of moderate to vigorous physical activity/week. All participants received a remotely tracked fitness wearable. Demographic and disease-based characteristics were collected at baseline to assess group differences. End-of-treatment surveys were conducted to assess acceptability, and inductive qualitative analysis was performed on two open-ended questions for both participant and guardian. RESULTS: Of 400 patients screened for eligibility, 37 were randomized (19 to waitlist control, 18 to treatment) with a recruitment rate of 4/month and an attrition rate of 2.7%. No demographic or disease characteristic differences were observed between groups. High fitness wearable adherence was observed in 35 participants. Median telehealth visit compliance was 83%. Qualitative analysis identified 3 categories: accountability and motivation (>30% citations from participants and parents relating to instructor motivation and accountability), the interplay of physical or mental health and physical activity (44% participant physical health), and personalization of the program to limit barriers to implementation (52% participant activity type, 44% participant education). CONCLUSION: Telehealth-supported physical activity intervention is feasible in children with CKD with low attrition rates and high compliance to visits. Participants and guardians identified personalization and engagement strategies as central to their experience of the program, suggesting these may be important to intervention success. CI - (c) 2026. The Author(s). FAU - Wong Vega, Molly R AU - Wong Vega MR AUID- ORCID: 0000-0003-4732-4996 AD - Department of Renal & Pheresis Services, Texas Children's Hospital, Houston, TX, USA. mvega@bcm.edu. AD - Department of Pediatrics, Section of Pediatric Nephrology, Baylor College of Medicine, Houston, TX, USA. mvega@bcm.edu. AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. mvega@bcm.edu. FAU - Johnston, Craig A AU - Johnston CA AUID- ORCID: 0009-0002-9533-1883 AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. FAU - Bily, Morgan AU - Bily M AD - Department of Renal & Pheresis Services, Texas Children's Hospital, Houston, TX, USA. FAU - Walsh, David W AU - Walsh DW AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. FAU - LaVoy, Emily C AU - LaVoy EC AUID- ORCID: 0000-0002-9505-0144 AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. FAU - Jennings, Kristofer AU - Jennings K AUID- ORCID: 0000-0002-5442-9326 AD - Department of Biostatistics, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA. FAU - Akcan-Arikan, Ayse AU - Akcan-Arikan A AUID- ORCID: 0000-0002-5123-6713 AD - Department of Pediatrics, Section of Pediatric Nephrology, Baylor College of Medicine, Houston, TX, USA. AD - Department of Pediatrics, Section of Critical Care Medicine, Baylor College of Medicine, Houston, TX, USA. FAU - Markofski, Melissa M AU - Markofski MM AUID- ORCID: 0000-0003-0214-4246 AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. LA - eng GR - 22-01657/ACSM Foundation/ PT - Journal Article DEP - 20261014 PL - Germany TA - Pediatr Nephrol JT - Pediatric nephrology (Berlin, Germany) JID - 8708728 SB - IM OTO - NOTNLM OT - Adolescents OT - Compliance OT - Exercise OT - Qualitative OT - Telemedicine COIS- Declarations. Conflict of interest: The authors declare that no competing interests. EDAT- 2026/10/14 18:14 MHDA- 2026/10/14 18:14 CRDT- 2026/10/14 14:56 PHST- 2026/06/04 00:00 [received] PHST- 2026/09/02 00:00 [accepted] PHST- 2026/08/13 00:00 [revised] PHST- 2026/10/14 18:14 [medline] PHST- 2026/10/14 18:14 [pubmed] PHST- 2026/10/14 14:56 [entrez] AID - 10.1007/s00467-026-07560-8 [pii] AID - 10.1007/s00467-026-07560-8 [doi] PST - aheadofprint SO - Pediatr Nephrol. 2026 Oct 14. doi: 10.1007/s00467-026-07560-8. PMID- 42872516 OWN - NLM STAT- Publisher LR - 20261022 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) DP - 2026 Oct 14 TI - Development of an anthropometric-based algorithm to estimate feeding tube insertion depth in neonates. LID - 10.1002/jpn3.70608 [doi] AB - OBJECTIVE: To develop an anthropometric-based algorithm for estimating feeding tube (FT) insertion depth in neonates using retrospectively collected radiographic data. METHODS: This observational study reviewed records of infants admitted to a Danish level IV Neonatal Intensive Care Unit from January 2023 to December 2024. Infants with FT placement, using the conventional Nose-Ear-Xiphoid (NEX) method, and radiographic verification within 24 h were included. Radiographically verified FT position and anthropometric data were used to develop new linear and multivariate quadratic models to optimize placement. RESULTS: Among 198 infants were included (median gestational age [GA] of 35 + 0 weeks [interquartile range, IQR:28 + 6-38 + 1]), 301 radiographic images showed, 144 FTs located at lumbar vertebra 1 (L1), 139 within one vertebra of L1, and 18 outside the stomach. Radiologists recommended adjustment in 107 images. Linear models (weight- or length-dependent) showed strong predictive power (R(2) > 0.84), while the multivariate quadratic model reduced bias and achieved R(2) = 0.88, confirmed by cross-validation. Prediction accuracy within the predefined target range (L1 +/- 1.5 cm) was 77% n, compared with 64% of clinically acceptable NEX placed tubes (p < 0.001). The optimal algorithm was: FT depth = -3.46 + 0.00229 x weight (g) - 9.48 x 10(-8) x weight (g)(2) + 0.5992 x length (cm) -0.005918 x length(cm)(2) + 0.07808 x correted GA(w). CONCLUSION: The quadratic prediction model showed good internal performance and reduced bias at anthropometric extremes, offering a standardized approach to optimize FT placement and enhance safety in neonatal care. Prospective external validation is required before clinical implementation. CI - (c) 2026 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Lauritsen, Julius V AU - Lauritsen JV AD - Department of Neonatology, Copenhagen University Hospital, Rigshospitalet, Denmark. FAU - Heiring, Christian AU - Heiring C AD - Department of Neonatology, Copenhagen University Hospital, Rigshospitalet, Denmark. AD - Copenhagen Academy for Medical Education and Simulation, University of Copenhagen, Copenhagen, Denmark. FAU - Wulff, Line AU - Wulff L AD - Department of Neonatology, Copenhagen University Hospital, Rigshospitalet, Denmark. FAU - Kappel, Susanne S AU - Kappel SS AUID- ORCID: 0000-0002-2023-298X AD - Department of Neonatology, Copenhagen University Hospital, Rigshospitalet, Denmark. FAU - Aunsholt, Lise AU - Aunsholt L AUID- ORCID: 0000-0003-0965-429X AD - Department of Neonatology, Copenhagen University Hospital, Rigshospitalet, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. LA - eng GR - None/ PT - Journal Article DEP - 20261014 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM OTO - NOTNLM OT - NEX OT - NICU OT - X-ray OT - enteral feeding EDAT- 2026/10/14 18:14 MHDA- 2026/10/14 18:14 CRDT- 2026/10/14 13:40 PHST- 2026/06/10 00:00 [revised] PHST- 2025/11/05 00:00 [received] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/10/14 18:14 [pubmed] PHST- 2026/10/14 18:14 [medline] PHST- 2026/10/14 13:40 [entrez] AID - 10.1002/jpn3.70608 [doi] PST - aheadofprint SO - J Pediatr Gastroenterol Nutr. 2026 Oct 14. doi: 10.1002/jpn3.70608. PMID- 42871714 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261014 LR - 20261015 IS - 2980-2156 (Electronic) IS - 2980-2156 (Linking) VI - 48 IP - 5 DP - 2026 Sep TI - Limited Public Health Utility of LCT Genotyping for Lactose Intolerance Screening in Adolescents: A Cross-Sectional Study from Turkiye. PG - 505-511 LID - 10.14744/cpr.2026.33422 [doi] AB - OBJECTIVE: Lactose intolerance (LI) is a common cause of gastrointestinal complaints in adolescents and young adults, often leading to unnecessary dietary restrictions and reduced calcium intake. Although lactase non-persistence (LNP) is genetically determined, its clinical expression varies considerably. Genetic variants associated with lactase persistence/non-persistence (LCT/MCM6 locus), particularly rs4988235 and rs3754686, are frequently used in genetic testing; however, their clinical utility remains uncertain, especially in populations with a high prevalence of LNP, such as Turkiye. MATERIALS AND METHODS: In this cross-sectional study, 209 individuals aged 12-25 years were evaluated. Lactose-related symptoms were assessed using a validated questionnaire (a score >/=7 defined symptomatic individuals). Consumption of raw milk and fermented dairy products was recorded using a standardized frequency scale. Genotyping of rs4988235 and rs3754686 was performed using TaqMan real-time PCR. Associations between genotype, symptom status, age at symptom onset, and dietary patterns were statistically analyzed. RESULTS: Among the participants, 116 (55.5%) were symptomatic and 93 (44.5%) were asymptomatic. Symptomatic individuals were significantly older (p<0.001). The genotype distributions of rs4988235 and rs3754686 did not differ between symptomatic and asymptomatic individuals and were not associated with age at symptom onset. Dairy consumption patterns were not associated with symptom severity, although fermented dairy consumption was slightly higher among symptomatic individuals (p=0.046). CONCLUSION: Common LCT/MCM6 variants did not predict clinical LI in this adolescent and young adult population. Therefore, routine genetic testing appears unlikely to provide limited additional value in supporting the diagnosis of lactose intolerance, particularly in populations with a high prevalence of LNP. Symptom-based assessment and functional testing should remain central to diagnosis and management, and, supporting appropriate nutritional guidance and avoiding unnecessary dietary restriction. CI - Copyright (c) Author(s). FAU - Mutlu, Hatice AU - Mutlu H AD - Department of Pediatric Genetics, Ankara University Faculty of Medicine, Ankara, Turkiye. AD - Rare Disease Application and Research Center (NADIR), Ankara University, Ankara, Turkiye. FAU - Eker, Ece AU - Eker E AD - Department of Pediatric Genetics, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Cetinkaya, Fulya AU - Cetinkaya F AD - Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Egin, Yonca AU - Egin Y AD - Department of Pediatric Genetics, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Aydin, Sengul AU - Aydin S AD - Department of Pediatric Genetics, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Vatansever, Goksel AU - Vatansever G AD - Department of Pediatrics, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Guven, Ayse Gul AU - Guven AG AD - Department of Adolescent Health, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Aycan, Zehra AU - Aycan Z AD - Department of Adolescent Health, Ankara University Faculty of Medicine, Ankara, Turkiye. AD - Department of Pediatric Endocrinology, Ankara University Faculty of Medicine, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260929 PL - Turkey TA - J Clin Pract Res JT - Journal of clinical practice and research JID - 9919014495706676 PMC - PMC13659205 OTO - NOTNLM OT - Adolescents OT - LCT OT - MCM6 OT - dairy consumption OT - lactose intolerance COIS- The authors have no conflicts of interest to declare. EDAT- 2026/10/14 18:14 MHDA- 2026/10/14 18:15 PMCR- 2026/09/29 CRDT- 2026/10/14 11:20 PHST- 2026/02/25 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/10/14 18:15 [medline] PHST- 2026/10/14 18:14 [pubmed] PHST- 2026/10/14 11:20 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - JCPR-48-505 [pii] AID - 10.14744/cpr.2026.33422 [doi] PST - epublish SO - J Clin Pract Res. 2026 Sep 29;48(5):505-511. doi: 10.14744/cpr.2026.33422. eCollection 2026 Sep. PMID- 42871394 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261015 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Cross-cultural adaptation and initial psychometric evaluation of the fruit and vegetable self-efficacy scales among secondary school adolescents in Selangor, Malaysia. PG - 1920784 LID - 10.3389/fpubh.2026.1920784 [doi] LID - 1920784 AB - Fruit and vegetable self-efficacy may influence adolescent dietary behavior, yet culturally adapted measures for Malaysian adolescents remain limited. This study aimed to cross-culturally adapt the 17-item Fruit Self-Efficacy (FSE) and Vegetable Self-Efficacy (VSE) scales into Malay and obtain initial evidence on their measurement properties. The study comprised two sequential phases. Phase 1 involved forward and backward translation, cognitive debriefing with five adolescents, linguistic equivalence assessment by six experts, content validity assessment by nine experts, qualitative and quantitative face validity assessment involving 15 unique adolescents, and pretesting with 37 adolescents. Phase 2 comprised an initial psychometric evaluation among 128 adolescents from four classes in one purposively selected public secondary school in Selangor. The adaptation process included age-appropriate refinements to the linguistic and contextual aspects of fruit and vegetable preparation, snacks, social occasions, serving terminology, and meal contexts. In particular, "pieces of fruit" was adapted to "servings of fruit" and supported by a pictorial serving guide, while "hot meal" was contextualized as "main meal." All source items met the prespecified content-validity criteria. Scale-level content-validity indices were 0.99 for FSE and 0.95 for VSE, while scale-level face-validity indices ranged from 0.95 to 0.97. One FSE item with an initial clarity index below the criterion was revised using concrete preparation examples and reassessed. In the separate psychometric sample, the prespecified one-factor FSE model showed acceptable fit (CFI = 0.974, TLI = 0.970, RMSEA = 0.069, SRMR = 0.061), although pronounced item-level ceiling effects were observed. The prespecified VSE model showed substantial misfit (RMSEA = 0.136, SRMR = 0.099), and its structural validity was not established. A same-sample post hoc specification with six correlated residuals remained hypothesis-generating because its RMSEA was 0.094. The multistage process produced linguistically and culturally adapted FSE and VSE scales that met the prespecified content and face-validity criteria among the expert and adolescent samples assessed. However, evidence supporting the one-factor structure was stronger for FSE than VSE. Further cognitive investigation and adequately powered, independent multisite evaluation across diverse ethnic and age groups are required before broader use. CI - Copyright (c) 2026 Zaini, Jabir, Mat Ludin, Abd Talib and Ishak. FAU - Zaini, Zanariah AU - Zaini Z AD - Centre for Toxicology and Health Risk, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. AD - Institute for Health Behavioural Research, National Institutes of Health, Ministry of Health, Shah Alam, Malaysia. FAU - Jabir, Nursyazwani AU - Jabir N AD - Institute for Health Behavioural Research, National Institutes of Health, Ministry of Health, Shah Alam, Malaysia. FAU - Mat Ludin, Arimi Fitri AU - Mat Ludin AF AD - Centre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. FAU - Abd Talib, Ruzita AU - Abd Talib R AD - Centre for Community Health Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. FAU - Ishak, Ismarulyusda AU - Ishak I AD - Centre for Toxicology and Health Risk, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. LA - eng PT - Journal Article DEP - 20260929 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Malaysia MH - Psychometrics MH - *Fruit MH - *Self Efficacy MH - *Vegetables MH - Adolescent MH - Female MH - *Cross-Cultural Comparison MH - Male MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Schools PMC - PMC13658580 OTO - NOTNLM OT - adolescents OT - cross-cultural adaptation OT - fruit and vegetable intake OT - questionnaire adaptation OT - self-efficacy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/14 11:34 MHDA- 2026/10/14 11:35 PMCR- 2026/09/29 CRDT- 2026/10/14 09:51 PHST- 2026/06/26 00:00 [received] PHST- 2026/09/09 00:00 [revised] PHST- 2026/09/14 00:00 [accepted] PHST- 2026/10/14 11:35 [medline] PHST- 2026/10/14 11:34 [pubmed] PHST- 2026/10/14 09:51 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1920784 [doi] PST - epublish SO - Front Public Health. 2026 Sep 29;14:1920784. doi: 10.3389/fpubh.2026.1920784. eCollection 2026. PMID- 42871234 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261014 LR - 20261015 IS - 1179-1411 (Print) IS - 1179-1411 (Electronic) IS - 1179-1411 (Linking) VI - 18 DP - 2026 TI - Advanced Maternal Age and Risk of Large-for-Gestational-Age Infants: Mediating Roles of Prenatal Body Mass Index and Specific Lipid Profiles. PG - 642291 LID - 10.2147/IJWH.S642291 [doi] LID - 642291 AB - BACKGROUND: Advanced maternal age (AMA) is associated with adverse pregnancy outcomes, but the mechanisms linking AMA to fetal overgrowth remain poorly quantified. This retrospective cohort study aimed to estimate the potential statistical mediating roles of prenatal BMI and blood lipids in the association between AMA and large-for-gestational-age (LGA) infants. METHODS: In this retrospective cohort study, 11,504 singleton pregnancies (28-41 weeks) in Changzhou, China, were analyzed. Women were classified as AMA (>/=35 years, n=1,330) or non‑AMA (n=10,174). Multivariable regression and mediation analyses assessed associations between AMA, lipid profiles, BMI, and LGA risk. RESULTS: AMA pregnancies showed significantly higher LGA rates than non-AMA pregnancies (24.44% vs 14.37%, P<0.001). After adjustment, AMA independently increased LGA risk (adjusted OR: 1.37, 95% CI: 1.18-1.60, P<0.001). AMA was associated with higher prenatal BMI (beta=0.37 kg/m(2)), elevated triglycerides (beta=0.27 mmol/L), and lower low density lipoprotein-cholesterol (LDL-C) (beta=-0.07 mmol/L) (all P<0.001). These metabolic factors independently predicted LGA risk: BMI (adjusted OR: 1.20 per 1 kg/m(2) increase), triglycerides (adjusted OR: 1.13 per 1 mmol/L increase), and LDL-C (adjusted OR: 1.32 per 1 mmol/L decrease) (all P<0.001). Exploratory mediation analysis estimated that prenatal BMI statistically accounted for 19.8% of the total AMA‑LGA effect, while triglycerides and LDL‑C accounted for 5.1% and 2.8%, respectively. CONCLUSION: AMA is independently associated with increased LGA risk, and this association is statistically partially mediated by higher BMI, elevated triglycerides, and lower LDL‑C. Given the retrospective observational design and the single‑timepoint measurement of lipids at delivery, these findings should be interpreted as statistical decompositions of associations rather than as causal. Nevertheless, they suggest that BMI and lipid profiles may be useful for risk stratification in older pregnant women, though prospective validation is warranted. CI - (c) 2026 Zhang et al. FAU - Zhang, Bin AU - Zhang B AD - Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, People's Republic of China. FAU - Yan, Qi AU - Yan Q AD - Department of Obstetrics and Gynecology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, People's Republic of China. FAU - Zhan, Zhaolong AU - Zhan Z AUID- ORCID: 0009-0005-6012-0658 AD - Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, People's Republic of China. FAU - Chen, Xusheng AU - Chen X AUID- ORCID: 0009-0003-5032-8709 AD - Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, People's Republic of China. FAU - Yuan, Xiaosong AU - Yuan X AD - Department of Medical Genetics, Changzhou Maternal and Child Health Care Hospital, Changzhou Medical Center, Nanjing Medical University, Changzhou, People's Republic of China. LA - eng PT - Journal Article DEP - 20261008 PL - New Zealand TA - Int J Womens Health JT - International journal of women's health JID - 101531698 PMC - PMC13658422 OTO - NOTNLM OT - advanced maternal age OT - body mass index OT - large for gestational age OT - lipid profiles OT - mediation analysis COIS- The authors declare that they have no conflicts of interest. EDAT- 2026/10/14 11:34 MHDA- 2026/10/14 11:35 PMCR- 2026/10/08 CRDT- 2026/10/14 08:43 PHST- 2026/07/29 00:00 [received] PHST- 2026/09/30 00:00 [accepted] PHST- 2026/10/14 11:35 [medline] PHST- 2026/10/14 11:34 [pubmed] PHST- 2026/10/14 08:43 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - 642291 [pii] AID - 10.2147/IJWH.S642291 [doi] PST - epublish SO - Int J Womens Health. 2026 Oct 8;18:642291. doi: 10.2147/IJWH.S642291. eCollection 2026. PMID- 42871191 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261015 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Initial screening positivity for suspected scoliosis and machine learning-assisted risk prioritization: a school-based cross-sectional study in Wuhai, Inner Mongolia, China. PG - 1923480 LID - 10.3389/fpubh.2026.1923480 [doi] LID - 1923480 AB - BACKGROUND: Questionnaire-based prescreening is inexpensive, but its ability to identify students with abnormal scoliosis screening findings is uncertain. We assessed whether questionnaire variables improved prediction beyond a demographic and anthropometric baseline and whether simple on-site physical signs could further improve risk prioritization. The outcome was initial screening positivity, defined by a positive Adams forward-bend test together with an angle of trunk rotation (ATR) of >/=5 degrees . METHODS: This school-based cross-sectional study included 3,559 students aged 10-18 years from four schools in Wuhai, Inner Mongolia, China. Participants underwent anthropometry, postural examination, the Adams test, electronic ATR measurement after a visually positive Adams test, and a structured questionnaire. Questionnaire models were assessed first. As questionnaire variables did not improve the demographic and anthropometric baseline, the final models used age, sex, grade, BMI, shoulder asymmetry, and foot arch morphology. Logistic regression, random forest, and XGBoost were evaluated with five-fold stratified cross-validation repeated three times. RESULTS: Of 3,559 students, 392 (11.01%) met the initial screening-positive definition. Among models without physical signs, the demographic and anthropometric baseline model performed best (ROC-AUC, 0.633; PR-AUC, 0.163), while adding all or selected questionnaire variables did not improve performance. Among physical-sign models, random forest had the highest ROC-AUC (0.787) and PR-AUC (0.400), and the lowest Brier score (0.082), although its ROC-AUC gain over logistic regression was modest (0.014; 95% CI, -0.001 to 0.029). Prioritizing the top 30% by risk identified 258 of 392 positive results (65.8%); approximately 60.4% of students required prioritization to achieve 90% sensitivity. CONCLUSION: Questionnaire information did not support individual prescreening. Simple physical signs improved internal risk ranking for initial screening positivity, but the model cannot replace the combined screening procedure or diagnosis. External validation against clinical and radiographic reference standards is needed. CI - Copyright (c) 2026 Wang, Liu, Wang, Duan, Zhang, Li, Yan and Hai. FAU - Wang, Hongyan AU - Wang H AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Liu, Xiafei AU - Liu X AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Wang, Biao AU - Wang B AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Duan, Lijuan AU - Duan L AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Zhang, Xia AU - Zhang X AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Li, Ying AU - Li Y AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Yan, Cuitao AU - Yan C AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. FAU - Hai, Donghu AU - Hai D AD - Wuhai Hospital of Traditional Chinese and Mongolian Medicine, Wuhai, Inner Mongolia Autonomous Region, China. LA - eng PT - Journal Article DEP - 20260929 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - China/epidemiology MH - *Scoliosis/diagnosis/epidemiology MH - Child MH - Female MH - *Machine Learning MH - Male MH - Adolescent MH - Surveys and Questionnaires MH - *Mass Screening/methods MH - Risk Assessment MH - Schools PMC - PMC13658430 OTO - NOTNLM OT - adolescents OT - children OT - machine learning OT - risk prioritization OT - school health OT - scoliosis screening COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/14 11:34 MHDA- 2026/10/14 11:35 PMCR- 2026/09/29 CRDT- 2026/10/14 08:27 PHST- 2026/06/30 00:00 [received] PHST- 2026/08/28 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/14 11:35 [medline] PHST- 2026/10/14 11:34 [pubmed] PHST- 2026/10/14 08:27 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1923480 [doi] PST - epublish SO - Front Public Health. 2026 Sep 29;14:1923480. doi: 10.3389/fpubh.2026.1923480. eCollection 2026. PMID- 42870901 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261014 LR - 20261015 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Negative school gossip, self-esteem, and exercise intention among Chinese adolescents: a mediation model. PG - 1923752 LID - 10.3389/fpsyg.2026.1923752 [doi] LID - 1923752 AB - PURPOSE: This study examined the associations among negative school gossip, self-esteem, and general exercise intention among Chinese adolescents, with particular attention to the mediating role of self-esteem and the relevance of these associations to physical education (PE) and school-based movement contexts. METHODS: A cross-sectional online questionnaire survey was conducted among 1,713 junior middle school students in China. Negative school gossip, self-esteem, and exercise intention were assessed using established self-report scales. Data were analyzed using latent-variable structural equation modeling in Mplus 8.3. Common method bias, reliability, convergent validity, discriminant validity, and model fit were examined before testing the mediation model. Bias-corrected bootstrap analysis with 2,000 bootstrap samples was used to test the indirect association. A sensitivity analysis was conducted by controlling for gender, grade, region, parental education, only-child status, and family economic status. RESULTS: The three-factor measurement model showed better fit than alternative measurement models, and the measures demonstrated acceptable reliability and validity. In the main structural model, negative school gossip was negatively associated with self-esteem (beta = -0.157, p < 0.001) and exercise intention (beta = -0.063, p = 0.031), while self-esteem was positively associated with exercise intention (beta = 0.240, p < 0.001). The standardized indirect association from negative school gossip to exercise intention through self-esteem was significant [beta = -0.038, 95% bootstrap CI (-0.055, -0.024)], accounting for 37.62% of the total association. The pattern remained stable after controlling for demographic covariates. CONCLUSION: Negative school gossip was associated with weaker general exercise intention among Chinese adolescents, and self-esteem partly accounted for this association. Although exercise intention was not measured specifically for PE lessons, the findings are relevant to PE because school movement contexts are highly visible and peer-evaluative settings in which reputation-based exclusion and stigma may reduce psychological safety. The results therefore suggest that supportive peer climates and protection from gossip-related exclusion may be important for inclusive PE and equitable participation in school-based physical activity. CI - Copyright (c) 2026 Ma and Chen. FAU - Ma, Jiaxin AU - Ma J AD - School of Humanities and Arts, Deyang College of Urban Rail Transit, Deyang, Sichuan, China. FAU - Chen, Xingtong AU - Chen X AD - School of Sports Training, Chengdu Sport University, Chengdu, Sichuan, China. LA - eng PT - Journal Article DEP - 20260929 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13657928 OTO - NOTNLM OT - Chinese adolescents OT - exercise intention OT - mediation OT - negative school gossip OT - self-esteem OT - structural equation modeling COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/14 11:34 MHDA- 2026/10/14 11:35 PMCR- 2026/09/29 CRDT- 2026/10/14 05:35 PHST- 2026/06/30 00:00 [received] PHST- 2026/09/14 00:00 [revised] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/10/14 11:35 [medline] PHST- 2026/10/14 11:34 [pubmed] PHST- 2026/10/14 05:35 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1923752 [doi] PST - epublish SO - Front Psychol. 2026 Sep 29;17:1923752. doi: 10.3389/fpsyg.2026.1923752. eCollection 2026. PMID- 42870848 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261014 LR - 20261015 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Construction and empirical testing of a verifiable food safety complaint risk-triage model using human foods complaint system data from the United States Food and Drug Administration. PG - 1919174 LID - 10.3389/fnut.2026.1919174 [doi] LID - 1919174 AB - BACKGROUND: Food safety complaint systems contain large numbers of heterogeneous adverse-event reports, but surveillance use requires reproducible data sources and interpretable rules for ranking reports that may involve severe outcomes. OBJECTIVE: To construct and test a transparent case-level logistic triage model that assigns FDA Human Foods Complaint System (HFCS) reports an urgent-priority score for earlier human review. METHODS: The official HFCS quarterly workbook was downloaded from the FDA website on 2026-05-13, and case-based reports received from January 1, 2004 through December 31, 2025 were analyzed (n = 149,642). Predictors were derived from validated age and date fields, sex, suspected product descriptors, MedDRA preferred-term counts, symptom-domain indicators, report year, and event-to-receipt lag. Product-group proportions were summarized with unadjusted Wilson 95% confidence intervals and interpreted descriptively. A balanced logistic regression model was assessed on a stratified test set. RESULTS: Urgent-priority outcomes occurred in 47,093 reports (31.47%). Death appeared in 17,005 reports and hospitalization in 23,405. The hospitalization proportion was 24.9% (95% CI, 24.5-25.3%) among dietary-supplement reports and 18.2% (16.3-20.3%) among infant/baby-food reports; these unadjusted proportions were not interpreted as population risk differences. The model achieved an AUC of 0.723, PR-AUC of 0.526, Brier score of 0.214, Brier skill score of 0.008, a calibration intercept of -0.03, and a calibration slope of 0.91 on 37,411 test cases. Symptom count and the infant/baby-food indicator had the largest positive model weights. CONCLUSION: HFCS data can support reproducible complaint triage. The model is suitable for ordering reports for human review, whereas product-group contrasts and raw predicted probabilities require cautious interpretation and temporal or external validation. CI - Copyright (c) 2026 Chen. FAU - Chen, Jinming AU - Chen J AD - College of Food Science and Engineering, Shanxi Agricultural University, Taigu, Shanxi, China. LA - eng PT - Journal Article DEP - 20260929 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13657942 OTO - NOTNLM OT - United States Food and Drug Administration OT - adverse events OT - complaint triage OT - food safety OT - machine learning OT - reproducibility of results COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/14 11:34 MHDA- 2026/10/14 11:35 PMCR- 2026/09/29 CRDT- 2026/10/14 05:19 PHST- 2026/06/25 00:00 [received] PHST- 2026/08/20 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/14 11:35 [medline] PHST- 2026/10/14 11:34 [pubmed] PHST- 2026/10/14 05:19 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - 10.3389/fnut.2026.1919174 [doi] PST - epublish SO - Front Nutr. 2026 Sep 29;13:1919174. doi: 10.3389/fnut.2026.1919174. eCollection 2026. PMID- 42870691 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261016 IS - 1467-7687 (Electronic) IS - 1363-755X (Print) IS - 1363-755X (Linking) VI - 29 IP - 6 DP - 2026 Nov TI - Exploring a Range of Potential Factors Promoting and Constraining EF in South African Preschoolers. PG - e70289 LID - 10.1111/desc.70289 [doi] LID - e70289 AB - BACKGROUND: Socioeconomic disadvantage is widely associated with poorer cognitive and educational outcomes. However, emerging evidence suggests that children in low-income contexts may demonstrate resilience in executive function (EF) development. This study examined the predictors of EF in South African preschoolers from disadvantaged communities to identify modifiable, context-specific influences. METHODS: 125 Children (aged 3-5 years) and their caregivers were recruited from 15 early childhood centers in Cape Town. Children completed three tablet-based EF tasks from the Early Years Toolbox measuring working memory, inhibition, shifting, while caregivers reported on demographic variables, household assets, child sleep, child screen time, child exposure to violence, and parenting practices. Multiple linear regressions examined predictors of child EF, with exploratory analyses on a subset (n = 22) for hair cortisol analysis. RESULTS: Older child age (beta = 0.37, p < 0.001), caregiver secondary education (beta = 0.22, p = 0.003), and fewer sleep difficulties (beta = -0.45, p = 0.042) significantly predicted higher child EF scores, together explaining 25% of variance. Household assets, screen time, violence exposure, and parenting scores were non-significant. In the subsample, hair cortisol concentration correlated positively with EF (rho = 0.55, p = 0.009), suggesting potential adaptive calibration under adversity. CONCLUSIONS: Findings highlight that modifiable proximal factors (e.g., caregiver education and child sleep) shape EF development more strongly than socioeconomic indicators. Results challenge the presumed universality of SES-EF gradients and underscore the importance of culturally grounded, contextually validated measures for understanding resilience and early cognitive development in Majority World settings. CI - (c) 2026 The Author(s). Developmental Science published by John Wiley & Sons Ltd. FAU - Beukes, Johanna AU - Beukes J AUID- ORCID: 0000-0003-2644-7081 AD - SAMRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Cook, Caylee AU - Cook C AD - SAMRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. FAU - Howard, Steven J AU - Howard SJ AUID- ORCID: 0000-0002-1258-3210 AD - Early Start and School of Education, University of Wollongong, Wollongong, NSW, Australia. FAU - Scerif, Gaia AU - Scerif G AUID- ORCID: 0000-0002-6371-8875 AD - Department of Experimental Psychology, University of Oxford, Oxford, UK. FAU - Sharpley, Christopher F AU - Sharpley CF AUID- ORCID: 0000-0001-7922-4848 AD - Department of Neuroscience, University of New England, Armidale, NSW, Australia. FAU - Hart, Robert AU - Hart R AD - Department of Biomedical Sciences, University of New England, Armidale, NSW, Australia. FAU - Draper, Catherine AU - Draper C AUID- ORCID: 0000-0002-2885-437X AD - SAMRC/Wits Developmental Pathways for Health Research Unit, Department of Paediatrics, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. LA - eng GR - University of Wollongong/ GR - DSI-NRF Centre of Excellence in Human Development, University of the Witwatersrand, Johannesburg/ GR - University of Wollogong/ PT - Journal Article PL - England TA - Dev Sci JT - Developmental science JID - 9814574 RN - WI4X0X7BPJ (Hydrocortisone) SB - IM MH - Humans MH - Child, Preschool MH - Female MH - South Africa MH - Male MH - *Executive Function/physiology MH - Hydrocortisone/metabolism/analysis MH - *Child Development/physiology MH - Parenting MH - Memory, Short-Term/physiology MH - Hair/chemistry MH - Cognition/physiology MH - Socioeconomic Factors MH - Poverty MH - Sleep/physiology PMC - PMC13662612 OTO - NOTNLM OT - South Africa OT - executive function OT - preschool OT - socioeconomic status COIS- There is no conflict of interest in this project. EDAT- 2026/10/14 05:34 MHDA- 2026/10/14 05:35 PMCR- 2026/10/14 CRDT- 2026/10/14 04:04 PHST- 2026/08/26 00:00 [revised] PHST- 2025/10/30 00:00 [received] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/10/14 05:35 [medline] PHST- 2026/10/14 05:34 [pubmed] PHST- 2026/10/14 04:04 [entrez] PHST- 2026/10/14 00:00 [pmc-release] AID - DESC70289 [pii] AID - 10.1111/desc.70289 [doi] PST - ppublish SO - Dev Sci. 2026 Nov;29(6):e70289. doi: 10.1111/desc.70289. PMID- 42870588 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261016 IS - 2473-4209 (Electronic) IS - 0094-2405 (Linking) VI - 53 IP - 10 DP - 2026 Oct TI - Quantitative and qualitative magnetic resonance imaging-based analysis to predict postoperative disease progression in hepatocellular carcinoma. PG - e70692 LID - 10.1002/mp.70692 [doi] AB - BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most common abdominal malignancies and the third leading cause of cancer-related death globally. Predicting the postoperative prognosis of HCC remains an important area of clinical research. Many qualitative magnetic resonance imaging (MRI) indicators have been used for noninvasive and global assessment of HCC for diagnostic and prognostic purposes. However, the prognostic value of quantitative MRI parameters has not been extensively validated in multicenter cohorts. OBJECTIVE: This study aimed to verify whether MRI-based imaging features could improve prognostic prediction in patients with HCC. We developed prognostic models to predict the progression-free survival (PFS) of patients with HCC. METHODS: In this multicenter cohort study, 203 patients diagnosed with early- to intermediate-stage HCC were divided into a training dataset and an external validation dataset. In addition to clinical indicators, the candidates included qualitative and quantitative MRI data. Three noninvasive models were developed: the Clinical Model, the Radiological Model, and the Combined Model. The patients were stratified according to the risk of disease progression. Model performance was assessed through discrimination and calibration analyses, decision curve analysis was performed, and a clinical application was designed. In addition, the subgroups at different stages of the disease were analyzed, and PFS was compared between the high- and low-risk groups. RESULTS: Prognostic nutritional index, tumor-feeding vessels, mosaic architecture and the signal enhancement ratio (SER) parameter were identified as independent predictors of disease progression in patients with HCC. The Combined Model demonstrated superior performance compared with the Clinical and Radiological Models. The areas under the curve (AUCs) in the training dataset were 0.822, 0.748, and 0.795, whereas those in the validation dataset were 0.819, 0.758, and 0.677, respectively. The Combined Model also demonstrated favorable calibration and greater net clinical benefit on decision curve analysis. Its predictive ability remained consistent regardless of the Child-Pugh classification or Barcelona Clinic Liver Cancer stage. CONCLUSION: This study highlights the important role of quantitative and qualitative MRI assessments in evaluating the prognosis of patients with HCC and emphasizes the predictive value of SER parameter. However, these findings should nevertheless be interpreted with caution given the relatively limited sample size, despite the use of bootstrap internal validation and external validation. CI - (c) 2026 American Association of Physicists in Medicine. FAU - Wang, He AU - Wang H AD - Department of Radiology, Zhuhai People's Hospital, The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University, Zhuhai, China. FAU - Yin, Minggang AU - Yin M AD - School of Public Health, Southern Medical University, Guangzhou, China. FAU - Chen, Zhiyan AU - Chen Z AD - Department of Radiology, Zhuhai People's Hospital, The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University, Zhuhai, China. FAU - Zou, Feixiang AU - Zou F AD - Department of Radiology, Wuchuan Gelao and Miao Autonomous County People's Hospital, Zunyi, China. FAU - Chen, Yuan AU - Chen Y AD - Department of Interventional Treatment, Zhongshan City People's Hospital, Zhongshan, China. FAU - An, Taixue AU - An T AD - Department of Laboratory Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, China. FAU - Li, Qiyang AU - Li Q AD - Department of Radiology, Shenzhen People's Hospital, Shenzhen, China. FAU - Cai, Mingyue AU - Cai M AD - Department of Minimally Invasive Interventional Radiology, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. FAU - Fu, Siri AU - Fu S AD - Zhuhai Interventional Medical Centre, Zhuhai People's Hospital, The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University, Zhuhai, China. AD - Zhuhai Engineering Technology Research Center of Intelligent Medical Imaging, Zhuhai People's Hospital , The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University, Zhuhai, China. FAU - Yu, Xiangrong AU - Yu X AD - Department of Radiology, Zhuhai People's Hospital, The Affiliated Hospital of Beijing Institute of Technology, Zhuhai Clinical Medical College of Jinan University, Zhuhai, China. LA - eng GR - 82071915/National Natural Science Foundation of China/ GR - 2023A1515011384/Guangdong Basic and Applied Basic Research Foundation/ GR - 202201020570/Science and Technology Planning Project of Guangzhou/ GR - 2023LCTS-07/The Clinical Research Promotion Project of Zhuhai People's Hospital/ PT - Journal Article PT - Multicenter Study PT - Validation Study PL - United States TA - Med Phys JT - Medical physics JID - 0425746 SB - IM MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - *Carcinoma, Hepatocellular/surgery/diagnostic imaging/pathology MH - *Disease Progression MH - Image Processing, Computer-Assisted MH - *Liver Neoplasms/surgery/diagnostic imaging/pathology MH - *Magnetic Resonance Imaging MH - Postoperative Period MH - Prognosis OTO - NOTNLM OT - hepatocellular carcinoma OT - magnetic resonance imaging OT - prognosis OT - progression-free survival EDAT- 2026/10/14 05:33 MHDA- 2026/10/14 05:34 CRDT- 2026/10/14 03:34 PHST- 2026/07/14 00:00 [revised] PHST- 2025/04/01 00:00 [received] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/10/14 05:34 [medline] PHST- 2026/10/14 05:33 [pubmed] PHST- 2026/10/14 03:34 [entrez] AID - 10.1002/mp.70692 [doi] PST - ppublish SO - Med Phys. 2026 Oct;53(10):e70692. doi: 10.1002/mp.70692. PMID- 42870359 OWN - NLM STAT- Publisher LR - 20261014 IS - 1098-108X (Electronic) IS - 0276-3478 (Linking) DP - 2026 Oct 13 TI - Medical Student Meal Support for Patients With Eating Disorders. LID - 10.1002/eat.70241 [doi] AB - OBJECTIVE: Patients hospitalized for eating disorders (EDs) often experience distress during supervised meals, and medical trainees frequently report limited comfort caring for this population. We developed Meal Partners, a mealtime support initiative designed to support hospitalized pediatric patients with EDs while improving trainee confidence. The purpose of this study was to evaluate the feasibility and acceptability of this medical-student-led service. METHOD: Meal Partners was implemented at a tertiary pediatric hospital in collaboration with the Eating Disorder Interdisciplinary Team. Medical student volunteers completed structured training on inpatient ED care, mealtime support, and communication strategies. Hospitalized patients undergoing nutritional rehabilitation were referred for meal support. Patient, caregiver, and volunteer surveys assessed perceptions of the program, while meal completion percentages were compared between meals with and without volunteer support. Pre- and post-volunteering surveys evaluated volunteer comfort and understanding of ED care. RESULTS: Six hospitalized patients assented to participate, with four ultimately receiving meal support. Thirty-two medical students completed training, and post-volunteering surveys demonstrated increased comfort interacting with patients with EDs, improved understanding of the inpatient experience, and reduced uncertainty in these interactions. All volunteers reported that the experience would benefit their future clinical practice. DISCUSSION: Meal Partners demonstrates the feasibility and acceptability of a medical student-led mealtime support initiative for patients hospitalized with EDs. Preliminary findings suggest benefits for medical education supporting further expansion and evaluation of this low-cost intervention. CI - (c) 2026 The Author(s). International Journal of Eating Disorders published by Wiley Periodicals LLC. FAU - Suresh, Sriyaa AU - Suresh S AUID- ORCID: 0009-0001-5150-0545 AD - Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA. FAU - Singh, Shivani AU - Singh S AUID- ORCID: 0009-0009-3426-119X AD - Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA. FAU - English, Sadie AU - English S AUID- ORCID: 0009-0007-9345-7235 AD - Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA. FAU - Taylor, Julia AU - Taylor J AUID- ORCID: 0000-0002-3661-1773 AD - Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA. FAU - Boguszewski, Katherine AU - Boguszewski K AUID- ORCID: 0000-0002-9575-9428 AD - Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA. FAU - Manthe, Eva AU - Manthe E AUID- ORCID: 0009-0001-5180-5170 AD - Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA. FAU - Esselstyn, June AU - Esselstyn J AUID- ORCID: 0009-0006-7123-5984 AD - Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA. FAU - Stephens, Sara Groff AU - Stephens SG AUID- ORCID: 0000-0002-7416-3756 AD - Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, University of Virginia, Charlottesville, Virginia, USA. LA - eng GR - Department of Pediatrics, School of Medicine, University of Virginia/ PT - Journal Article DEP - 20261013 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM OTO - NOTNLM OT - adolescent medicine OT - eating disorders OT - inpatient care OT - supportive interventions OT - volunteer EDAT- 2026/10/14 05:33 MHDA- 2026/10/14 05:33 CRDT- 2026/10/14 00:39 PHST- 2026/10/05 00:00 [revised] PHST- 2026/06/08 00:00 [received] PHST- 2026/10/06 00:00 [accepted] PHST- 2026/10/14 05:33 [medline] PHST- 2026/10/14 05:33 [pubmed] PHST- 2026/10/14 00:39 [entrez] AID - 10.1002/eat.70241 [doi] PST - aheadofprint SO - Int J Eat Disord. 2026 Oct 13. doi: 10.1002/eat.70241. PMID- 42869922 OWN - NLM STAT- Publisher LR - 20261013 IS - 1348-4214 (Electronic) IS - 0916-9636 (Linking) DP - 2026 Oct 13 TI - Association between the triglyceride-glucose index and arterial stiffness in adolescents: the Wakayama study. LID - 10.1038/s41440-026-02837-9 [doi] AB - Insulin resistance plays an important role in early vascular dysfunction during adolescence. The triglyceride-glucose (TyG) index is a simple surrogate marker of insulin resistance. This study aimed to examine the association between the TyG index and arterial stiffness in adolescents. This cross-sectional study included 617 adolescents aged 15-18 years in a school-based setting. Arterial stiffness was assessed by brachial-ankle pulse wave velocity (baPWV) using an automated oscillometric device with appropriately sized cuffs. Blood samples were collected after an overnight fast to calculate the TyG index and the homeostasis model assessment of insulin resistance (HOMA-IR). When participants were categorized into tertiles of the TyG index, baPWV increased significantly across tertiles. This association was observed in both obese and non-obese participants. In multivariable linear regression models adjusting for age, sex, systolic blood pressure, BMI z-score, heart rate, HDL cholesterol, HbA1c, and serum uric acid, the TyG index remained independently associated with baPWV; however, this association was attenuated after further adjustment for HOMA-IR. Receiver operating characteristic curve analysis showed that the area under the curve for the TyG index was comparable to that for HOMA-IR in identifying elevated baPWV. These results suggest that the TyG index was significantly associated with arterial stiffness in adolescents, regardless of obesity status. Although its predictive performance was similar to that of HOMA-IR, the TyG index may serve as a practical marker of early vascular alterations in this population. CI - (c) 2026. The Author(s), under exclusive licence to The Japanese Society of Hypertension. FAU - Miyai, Nobuyuki AU - Miyai N AUID- ORCID: 0000-0002-7208-4405 AD - Graduate School of Health and Nursing Science, Wakayama Medical University, Wakayama, Japan. miyain@wakayama-med.ac.jp. FAU - Zhang, Yan AU - Zhang Y AD - Graduate School of Health and Nursing Science, Wakayama Medical University, Wakayama, Japan. FAU - Sougawa, Yukiko AU - Sougawa Y AD - Graduate School of Health and Nursing Science, Wakayama Medical University, Wakayama, Japan. FAU - Hayakawa, Hiroko AU - Hayakawa H AD - Graduate School of Health and Nursing Science, Wakayama Medical University, Wakayama, Japan. FAU - Tsuji, Kumiko AU - Tsuji K AD - Wakayama Faculty of Nursing, Tokyo Healthcare University, Wakayama, Japan. FAU - Terada, Kazufumi AU - Terada K AD - Faculty of Physical Education, Tenri University, Nara, Japan. FAU - Utsumi, Miyoko AU - Utsumi M AD - Graduate School of Health and Nursing Science, Wakayama Medical University, Wakayama, Japan. FAU - Arita, Mikio AU - Arita M AD - Sumiya Rehabilitation Hospital, Wakayama, Japan. LA - eng PT - Journal Article DEP - 20261013 PL - England TA - Hypertens Res JT - Hypertension research : official journal of the Japanese Society of Hypertension JID - 9307690 SB - IM OTO - NOTNLM OT - Adolescents OT - Arterial stiffness OT - Cardiovascular risk OT - Insulin resistance OT - TyG index COIS- Compliance with ethical standards. Conflict of interest: The authors declare no potential conflicts of interest with respect to the research, authorship, or publication of this article. Ethical approval: This study was conducted in accordance with the principles of the Declaration of Helsinki and its later amendments or comparable ethical standards. This study was approved by the Ethics Committee of the Wakayama Medical University (approval no. 596). Informed consent: Written informed consent for the use of health examination data for research purposes was obtained from all participants and their guardians, as appropriate, following explanation of the study aims and procedures. EDAT- 2026/10/14 05:33 MHDA- 2026/10/14 05:33 CRDT- 2026/10/13 23:31 PHST- 2026/08/11 00:00 [received] PHST- 2026/09/11 00:00 [accepted] PHST- 2026/09/08 00:00 [revised] PHST- 2026/10/14 05:33 [medline] PHST- 2026/10/14 05:33 [pubmed] PHST- 2026/10/13 23:31 [entrez] AID - 10.1038/s41440-026-02837-9 [pii] AID - 10.1038/s41440-026-02837-9 [doi] PST - aheadofprint SO - Hypertens Res. 2026 Oct 13. doi: 10.1038/s41440-026-02837-9. PMID- 42869441 OWN - NLM STAT- Publisher LR - 20261013 IS - 1527-330X (Electronic) IS - 1090-820X (Linking) DP - 2026 Oct 14 TI - Development and Validation of Two skin Quality Photonumeric Scales Assessing Skin Smoothness and Cheek Lines. LID - sjag217 [pii] LID - 10.1093/asj/sjag217 [doi] AB - BACKGROUND: Skin smoothness and cheek lines are key indicators of skin quality targeted by aesthetic treatments and surgery to improve perceived youthfulness and confidence. Validated photonumeric scales provide a standardized, reliable, and reproducible grading of skin quality. OBJECTIVES: To develop and validate two Canfield skin quality photonumeric scales assessing skin smoothness and cheek lines. METHODS: Two 5-level photonumeric scales for skin smoothness and cheek lines were developed. Validation consisted of three exercises: live validation, clinical relevance, and photographic validation. Five certified clinicians completing the grading in two sessions, two weeks apart and agreement was measured using Cicchetti-Allison kappa. Sixty-eight and 72 participants, respectively, attended validation for skin smoothness and cheek lines. Clinical relevance was evaluated by comparing ratings of 90 image pairs evaluated as clinically different and not clinically different. Photographic validation was completed as per live validation on the standardized images used for clinical relevance. RESULTS: For both scales, the live and photographic validation demonstrated almost perfect levels of intra-rater reliability (combined Kappas > 0.801) and substantial to almost-perfect inter-rater reliability (median pairwise Kappas > 0.728), across a diverse population. Clinical relevance showed a meaningful 1-point difference in pairs that are not clinically different and images with 1-point difference (p<0.001). CONCLUSIONS: The Canfield Skin Quality Scale - Skin Smoothness and the Canfield Skin Quality Scale - Cheek Lines are robust and reproducible outcome measures for use live and on images, supporting their use in clinical studies and practice across diverse populations. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of The Aesthetic Society. FAU - Lorenc, Z Paul AU - Lorenc ZP AD - Plastic surgeon in private practice, New York, NY. FAU - Bass, Lawrence S AU - Bass LS AD - Zucker School of Medicine at Hofstra/Northwell, Uniondale, NY. FAU - Betz-Stablein, Brigid AU - Betz-Stablein B AUID- ORCID: 0000-0003-3876-501X AD - Canfield Scientific, Inc., Parsippany, NJ. FAU - Cramer, Lisa AU - Cramer L AD - Canfield Scientific, Inc., Parsippany, NJ. FAU - Canfield, Doug AU - Canfield D AD - Canfield Scientific, Inc., Parsippany, NJ. FAU - Jones, Derek AU - Jones D AD - Skin Care and Laser Physicians of Beverly Hills, Beverly Hills, CA. FAU - Koh, Uyen AU - Koh U AD - Canfield Scientific Pty Ltd, Dural, Australia. FAU - Melione, Anthony AU - Melione A AD - Canfield Scientific, Inc., Parsippany, NJ. FAU - Moradi, Amir AU - Moradi A AD - Pacific Clinical Innovations, Vista, CA. FAU - Vickers, Jennifer L AU - Vickers JL AD - Dermatologist in private practice in Austin, TX. FAU - Woodward, Julie A AU - Woodward JA AD - Duke Integrated Health Practice, Durham, NC. FAU - Smith, Stacy AU - Smith S AD - California Dermatology & Clinical Research Institute, Encinitas, CA. LA - eng PT - Journal Article DEP - 20261014 PL - England TA - Aesthet Surg J JT - Aesthetic surgery journal JID - 9707469 SB - IM EDAT- 2026/10/13 23:36 MHDA- 2026/10/13 23:36 CRDT- 2026/10/13 20:05 PHST- 2026/05/01 00:00 [received] PHST- 2026/07/09 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/10/13 23:36 [medline] PHST- 2026/10/13 23:36 [pubmed] PHST- 2026/10/13 20:05 [entrez] AID - 8914573 [pii] AID - 10.1093/asj/sjag217 [doi] PST - aheadofprint SO - Aesthet Surg J. 2026 Oct 14:sjag217. doi: 10.1093/asj/sjag217. PMID- 42866214 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261013 LR - 20261014 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 9 DP - 2026 Sep 30 TI - Predictors of using biologics within one year after EEN therapy in pediatric Crohn's disease. PG - 381 LID - 10.21037/tp-2026-0515 [doi] LID - 381 AB - BACKGROUND: Biologics are commonly used as the second-line medication for maintenance of remission after exclusive enteral nutrition (EEN) induction in pediatric Crohn's disease (CD). However, predictors of using biologics after EEN therapy in CD are yet to be elucidated. This study explores the predictive factors for the application of biologics in children with CD who had finished 8 weeks of EEN induction. METHODS: Seventy-five patients were divided into derivation group (n=54) and validation group (n=21). Baseline characteristics were compared between biological group and non-biological group. Univariate and multivariate analyses were performed to correlate 102 laboratory indicators. Finally, binary stepwise logistic regression was used to construct a prediction model. RESULTS: The predictor identified for biologic use in the prediction model was complement C4 and red blood cell distribution width (RDW). Complement C4 [odds ratio (OR) =1.04, 95% confidence interval (CI): 1.01-1.07] and RDW (OR =1.41, 95% CI: 1.05-1.91) were identified as significant independent predictors (P<0.05). Patients with baseline complement C4 levels >0.415 g/L and RDW >13.5% were more likely to use biologics within 1 year after EEN. CONCLUSIONS: Complement C4 and RDW are predictors of biologic use within 1 year after EEN-induced clinical remission. Elevated complement C4 and RDW are associated with the use of biologics after induction of remission. However, extensive experimental validation is still required to confirm the above findings. CI - (c) AME Publishing Company. FAU - Wang, Xiaoxi AU - Wang X AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Hu, Yudie AU - Hu Y AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Lou, Jingan AU - Lou J AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Luo, Youyou AU - Luo Y AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Yu, Jindan AU - Yu J AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Fang, Youhong AU - Fang Y AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Tang, Lujing AU - Tang L AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Zhao, Hong AU - Zhao H AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Xu, Luojia AU - Xu L AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Peng, Kerong AU - Peng K AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Lv, Yao AU - Lv Y AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Chen, Jie AU - Chen J AD - Gastroenterology Department, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. LA - eng PT - Journal Article DEP - 20260817 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13655871 OTO - NOTNLM OT - Inflammatory bowel disease (IBD) OT - biologic OT - children OT - induction therapy OT - prediction COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0515/coif). The authors have no conflicts of interest to declare. EDAT- 2026/10/13 17:37 MHDA- 2026/10/13 17:38 PMCR- 2026/09/30 CRDT- 2026/10/13 13:27 PHST- 2026/05/26 00:00 [received] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/10/13 17:38 [medline] PHST- 2026/10/13 17:37 [pubmed] PHST- 2026/10/13 13:27 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - tp-15-9-381 [pii] AID - 10.21037/tp-2026-0515 [doi] PST - ppublish SO - Transl Pediatr. 2026 Sep 30;15(9):381. doi: 10.21037/tp-2026-0515. Epub 2026 Aug 17. PMID- 42866018 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261013 LR - 20261014 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - School-based high-intensity interval training for children: a focused systematic review of implementation and school-relevant outcomes. PG - 1952928 LID - 10.3389/fped.2026.1952928 [doi] LID - 1952928 AB - BACKGROUND: Schools are an important setting for physical-activity promotion, but limited curriculum time can constrain the implementation of exercise programmes. High-intensity interval training (HIIT) may offer a brief format for increasing vigorous activity during physical education (PE), classroom activity breaks, or other school-day opportunities. This review examined school-based HIIT delivery models, physical and cardiovascular outcomes, cognition and other school-relevant outcomes, and implementation, feasibility, and safety reporting. METHODS: Five electronic databases were searched for English-language studies published from January 2010 to May 9, 2026. Two reviewers independently screened records, assessed full texts, extracted data, and appraised risk of bias, with disagreements resolved by consensus. Eligible controlled studies evaluated a clearly defined HIIT intervention delivered in a school setting to children aged approximately 5-12 years and reported at least one physical, cardiovascular, cognitive, school-relevant, or implementation outcome. Owing to substantial heterogeneity in interventions and outcomes, findings were synthesised narratively in accordance with the Synthesis Without Meta-analysis (SWiM) reporting guideline. RESULTS: The searches identified 3,508 records; 1,370 duplicates were removed, 2,138 records were screened, 94 full-text reports were assessed, and six studies were included. Analysed sample sizes ranged from 18 to 67 participants. Interventions ranged from 6-minute classroom micro-sessions to 20-minute PE-based programmes delivered for 4-12 weeks. Some studies reported between-group or group-by-time findings favouring HIIT for selected functional-strength, aerobic-fitness, arterial-stiffness, and heart-rate-variability outcomes; other findings were limited to within-group change, and effects were not consistent across protocols. One study assessed inhibitory control and reported improvements after both HIIT and moderate-intensity continuous training, providing no evidence of a HIIT-specific cognitive advantage. No included study directly assessed mental health, academic attainment, attendance, or classroom engagement. Three studies were judged to have a high overall risk of bias and three raised some concerns. CONCLUSIONS: School-based HIIT may be a brief adjunct to, rather than a replacement for, comprehensive PE. Preliminary findings suggest possible benefits for selected fitness and cardiovascular outcomes, while evidence for cognitive, mental-health, and academic benefits remains limited or absent. Given the small evidence base and risk-of-bias concerns, these findings should be interpreted cautiously. The current findings apply to the primary-school-aged samples represented and should not be extrapolated to adolescents. Larger, adequately powered school trials with stronger implementation and outcome reporting are required. CI - (c) 2026 Yang, Lin and Lan. FAU - Yang, Lizhuo AU - Yang L AD - Wuhan Sports University, Wuhan, Hubei, China. FAU - Lin, Liping AU - Lin L AD - Guandian Middle School, Mingguang, Anhui, China. FAU - Lan, Zhuomei AU - Lan Z AD - Guandian Hospital, Mingguang, Anhui, China. LA - eng PT - Journal Article PT - Review DEP - 20260928 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13655682 OTO - NOTNLM OT - children OT - high-intensity interval training OT - narrative synthesis OT - physical education OT - school-based intervention OT - systematic review COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/13 17:37 MHDA- 2026/10/13 17:38 PMCR- 2026/09/28 CRDT- 2026/10/13 12:33 PHST- 2026/07/30 00:00 [received] PHST- 2026/09/14 00:00 [revised] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/10/13 17:38 [medline] PHST- 2026/10/13 17:37 [pubmed] PHST- 2026/10/13 12:33 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - 10.3389/fped.2026.1952928 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 28;14:1952928. doi: 10.3389/fped.2026.1952928. eCollection 2026. PMID- 42866012 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261013 LR - 20261014 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 17 DP - 2026 TI - Gut microbiota and health-related quality of life in paediatric inherited metabolic disorders: a narrative review and conceptual framework. PG - 1928657 LID - 10.3389/fmicb.2026.1928657 [doi] LID - 1928657 AB - Inherited metabolic disorders (IMDs) comprise more than 1,400 rare genetic conditions affecting paediatric patients worldwide. Despite advances in newborn screening and dietary management, many children experience chronic complications, gastrointestinal symptoms, and reduced health-related quality of life (HRQoL). Emerging evidence-predominantly from phenylketonuria (PKU)-suggests that gut microbiota may influence metabolic homeostasis and patient-centred outcomes in affected children. Because of substantial methodological heterogeneity and the rarity of individual disorders, we elected a narrative review format to synthesise current evidence rather than a formal quantitative synthesis. Electronic searches were performed in PubMed, Embase, and Web of Science from inception to February 2026. We synthesise current evidence regarding gut microbiota composition in major paediatric IMDs, including PKU, organic acidemias, glycogen storage diseases, lysosomal storage disorders, and mitochondrial diseases. For PKU, controlled studies report reduced microbial diversity and depletion of butyrate-producing taxa associated with long-term dietary treatment. For the remaining disorders, direct paediatric microbiome data are sparse or absent, and proposed links rely on mechanistic extrapolation from non-IMD populations. We present the gut microbiota-metabolism-quality of life axis as a conceptual framework that integrates microbial metabolites, intestinal barrier function, immune signalling, and patient-reported outcomes, while emphasising that direct causal evidence linking microbiota alterations to HRQoL in paediatric IMDs is currently lacking. Microbiota-directed interventions remain preliminary. Future multicentre longitudinal studies integrating microbiome profiling, multi-omics technologies, and validated patient-reported outcomes are needed to clarify causal mechanisms and therapeutic potential. Importantly, the available evidence is heterogeneous: direct paediatric microbiome evidence is strongest for PKU, whereas evidence for other IMDs is sparse and often observational, preclinical, or extrapolated from non-IMD populations. The proposed microbiota-metabolism-HRQoL axis is therefore presented as a hypothesis-generating framework rather than an established causal pathway. CI - Copyright (c) 2026 Dumbuya, Li, He, Li, Liu, Zhong, Huang and Chen. FAU - Dumbuya, John Sieh AU - Dumbuya JS AD - Department of Paediatrics, The First Affiliated Hospital of Hainan University, Haikou People's Hospital, Haikou, Hainan, China. FAU - Li, Yuanlong AU - Li Y AD - Department of Paediatrics, Hainan Women and Children's Medical Centre, Haikou, Hainan, China. FAU - He, Bo AU - He B AD - Department of Paediatrics, The First Affiliated Hospital of Hainan University, Haikou People's Hospital, Haikou, Hainan, China. FAU - Li, Guangxu AU - Li G AD - Department of Paediatrics, The First Affiliated Hospital of Hainan University, Haikou People's Hospital, Haikou, Hainan, China. FAU - Liu, Yuting AU - Liu Y AD - Department of Paediatrics, The First Affiliated Hospital of Hainan University, Haikou People's Hospital, Haikou, Hainan, China. FAU - Zhong, Youfeng AU - Zhong Y AD - Department of Paediatrics, The First Affiliated Hospital of Hainan University, Haikou People's Hospital, Haikou, Hainan, China. FAU - Huang, Shimei AU - Huang S AD - Department of Paediatrics, The First Affiliated Hospital of Hainan University, Haikou People's Hospital, Haikou, Hainan, China. FAU - Chen, Xiuling AU - Chen X AD - Department of Paediatrics, The First Affiliated Hospital of Hainan University, Haikou People's Hospital, Haikou, Hainan, China. LA - eng PT - Journal Article PT - Review DEP - 20260928 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC13655685 OTO - NOTNLM OT - gut microbiota OT - health-related quality of life OT - inherited metabolic disorders OT - narrative review OT - phenylketonuria OT - probiotics OT - short-chain fatty acids COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/13 17:37 MHDA- 2026/10/13 17:38 PMCR- 2026/09/28 CRDT- 2026/10/13 12:31 PHST- 2026/07/05 00:00 [received] PHST- 2026/09/11 00:00 [revised] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/10/13 17:38 [medline] PHST- 2026/10/13 17:37 [pubmed] PHST- 2026/10/13 12:31 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - 10.3389/fmicb.2026.1928657 [doi] PST - epublish SO - Front Microbiol. 2026 Sep 28;17:1928657. doi: 10.3389/fmicb.2026.1928657. eCollection 2026. PMID- 42865937 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261013 LR - 20261014 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Climate awareness and lower-meat eating among children and adolescents: potential behavioral pathways and contextual conditions. PG - 1967214 LID - 10.3389/fnut.2026.1967214 [doi] LID - 1967214 AB - Climate awareness is increasingly proposed as a motive for lower-meat eating, while research involving children and adolescents spans distinct outcomes, from knowledge and willingness to food provision and measured intake. This Mini Review synthesizes these outcome levels and the conditions that connect them. A targeted structured search of Web of Science and Scopus identified surveys, qualitative studies, message and food-education interventions, family and school provision studies, and nutritional analyses. Evidence was organized as climate-linked motivational, proximal behavioral, and intake-association evidence; provision- and intake-change evidence; and contextual or feasibility evidence. Climate-related motives coexist with health, taste, identity, convenience, and social norms. One preregistered study comprising two randomized message experiments reported changes in immediate sustainable choices and intentions. A cross-sectional youth analysis linked climate attitudes with current intake, retrospectively reported reduction, and future intention, whereas a provision-based family trial supplied the clearest within-study change in meat intake. Family gatekeeping, school-food systems, product acceptability, culture, affordability, nutrition, and equity shape opportunities across these routes. Age changes opportunities for dietary agency: decision control may be adult-led, shared, or youth-led within age groups and settings. Climate awareness therefore occupies one motivational position in a multilevel evidence map. Connecting motivation with acceptable, accessible, and nutritionally adequate food environments provides a testable framework for sustained dietary change. CI - Copyright (c) 2026 Xing and Wu. FAU - Xing, Lu AU - Xing L AD - School of Preschool Education, Changsha Normal University, Changsha, China. AD - School of Education, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. FAU - Wu, Xueqi AU - Wu X AD - Taylor's Culinary Institute, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. LA - eng PT - Journal Article PT - Review DEP - 20260928 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13656206 OTO - NOTNLM OT - adolescents OT - alternative proteins OT - children OT - climate awareness OT - lower-meat eating OT - school meals OT - sustainable diets COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/13 17:37 MHDA- 2026/10/13 17:38 PMCR- 2026/09/28 CRDT- 2026/10/13 12:05 PHST- 2026/08/13 00:00 [received] PHST- 2026/09/14 00:00 [revised] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/13 17:38 [medline] PHST- 2026/10/13 17:37 [pubmed] PHST- 2026/10/13 12:05 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - 10.3389/fnut.2026.1967214 [doi] PST - epublish SO - Front Nutr. 2026 Sep 28;13:1967214. doi: 10.3389/fnut.2026.1967214. eCollection 2026. PMID- 42865672 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261013 LR - 20261014 IS - 2296-4185 (Print) IS - 2296-4185 (Electronic) IS - 2296-4185 (Linking) VI - 14 DP - 2026 TI - Tibiotarsal mechanical behaviour is mainly a function of bone structure and not mineral density in female adolescent chickens. PG - 1812701 LID - 10.3389/fbioe.2026.1812701 [doi] LID - 1812701 AB - INTRODUCTION: Bone fragility and disuse osteoporosis in commercial egg-laying chickens is a major welfare concern. Efforts to address this have focused on eliciting increases in bone mass during growth by raising chickens in more spacious and complex housing systems that motivate increased physical activity. However, it remains unclear how these bone adaptations influence in vivo bone mechanical behaviour in chickens, namely, whole-bone stiffness and strength. METHODS: To investigate this, we sampled female chickens of two genetic strains (Lohmann Brown: brown-feathered, Lohmann LSL Lite: white-feathered) with different loading histories (sedentary: housed in cages with no opportunity for dynamic load bearing activity; active: raised in one of two styles of aviary housing systems requiring locomotion including jumping and other aerial transitions) just prior to the onset of sexual maturity at 16 weeks of age. We imaged their whole right tibiotarsi (ex vivo) using microCT and for the first time developed finite element models of the chicken tibiotarsi under controlled in vivo axial compressive loading on a limited sample size (n = 1, N = 6), which we validated with in vivo strain gauge measurements. Each bone was modelled with both homogeneous and heterogeneous material properties to assess the effects of tissue mineral density and bone structure on the mechanical behaviour. We also quantified a variety of structural measures along the bone length and determined their correlation to simulated mechanical behaviour. RESULTS: We found that consideration of volumetric tissue mineralization heterogeneity in our FE models had negligible influence on the modelled mechanical behaviour, and thus further analyses used only homogeneous FEMs. We identified bone area, total area, bone area ratio, bone thickness, eccentricity, normalized outer perimeter, and inner-to-outer perimeter ratio to be significantly correlated to decreased modelled stress. Increased activity levels was associated with lower modelled stresses in brown-, but not white-feathered chickens, and this pattern could be explained by differences in bone area, total area, and inner-to-outer perimeter ratio. CONCLUSION: These results suggest that, similar to what has been shown in humans, bone structure and not just mineral density is a critical determinant of mechanical behaviour and therefore fracture risk. We identify structural outcomes that can be candidates for genetic selection, targeting improved bone strength, a subset of which may adapt to loading in brown-feathered chickens. We also present a novel (in the poultry science field) approach to assess the relationship between bone structure and mechanical behaviour, which can be further used to inform genetic selection and breeding for improved bone strength and fracture resistance. CI - Copyright (c) 2026 Vitienes, Julien, Rentsch, Main, Widowski, Checa and Willie. FAU - Vitienes, Isabela AU - Vitienes I AD - Department of Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada. AD - Research Centre, Shriners Hospital for Children-Canada, Montreal, QC, Canada. AD - Department of Operative, Preventive and Pediatric Dentistry, Charite - Universitatsmedizin, Berlin, Germany. FAU - Julien, Catherine AU - Julien C AD - Research Centre, Shriners Hospital for Children-Canada, Montreal, QC, Canada. AD - Faculty of Dental Medicine and Oral Health Science, McGill University, Montreal, QC, Canada. FAU - Rentsch, Ana K AU - Rentsch AK AD - Department of Animal Bioscience, University of Guelph, Guelph, ON, Canada. FAU - Main, Russell P AU - Main RP AD - Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, United States. AD - Department of Basic Medical Sciences, Purdue University, Purdue, IN, United States. FAU - Widowski, Tina M AU - Widowski TM AD - Department of Animal Bioscience, University of Guelph, Guelph, ON, Canada. FAU - Checa, Sara AU - Checa S AD - Julius Wolff Institute, Charite-Universitatsmedizin Berlin, Berlin, Germany. AD - Institute of Biomechanics, Hamburg University of Technology (TUHH), Hamburg, Germany. FAU - Willie, Bettina M AU - Willie BM AD - Research Centre, Shriners Hospital for Children-Canada, Montreal, QC, Canada. AD - Faculty of Dental Medicine and Oral Health Science, McGill University, Montreal, QC, Canada. AD - College of Veterinary Medicine, Utah State University, Logan, UT, United States. LA - eng PT - Journal Article DEP - 20260928 PL - Switzerland TA - Front Bioeng Biotechnol JT - Frontiers in bioengineering and biotechnology JID - 101632513 PMC - PMC13655523 OTO - NOTNLM OT - bone adaptation OT - bone fragility OT - bone mechanical behaviour OT - bone structure OT - egg-laying hens COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/13 11:41 MHDA- 2026/10/13 11:42 PMCR- 2026/09/28 CRDT- 2026/10/13 09:30 PHST- 2026/02/17 00:00 [received] PHST- 2026/07/15 00:00 [revised] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/10/13 11:42 [medline] PHST- 2026/10/13 11:41 [pubmed] PHST- 2026/10/13 09:30 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - 1812701 [pii] AID - 10.3389/fbioe.2026.1812701 [doi] PST - epublish SO - Front Bioeng Biotechnol. 2026 Sep 28;14:1812701. doi: 10.3389/fbioe.2026.1812701. eCollection 2026. PMID- 42865505 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261014 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Evaluating the implementation of the Diabetes Body Project in a clinical cohort of Australian adolescents with type 1 diabetes. PG - 1958711 LID - 10.3389/fendo.2026.1958711 [doi] LID - 1958711 AB - INTRODUCTION: Adolescents with type 1 diabetes (T1D) are at increased risk of disordered eating behaviors (DEB) and eating disorders (ED) compared to their peers without T1D, contributing to increased diabetes-related complications, and elevated mortality risk. Despite this, there is a lack of targeted ED prevention interventions specifically designed for adolescents with T1D, within routine clinical care. The Diabetes Body Project (DBP) has demonstrated promising feasibility, acceptability, and reduction of DEB in young adults; however, its application in younger adolescents and real-world clinical settings has not been tested. OBJECTIVE: This study aims to extend previous DBP research by evaluating its implementation within a real-world Australian clinical service. The study will assess feasibility and acceptability and explore preliminary efficacy in relation to DEB and glycaemic control in an exclusively adolescent population, including a novel parent/caregiver component. METHODS: This protocol describes a pilot study that will recruit 24 female adolescents with T1D from the John Hunter Children's Hospital (JHCH) Diabetes Service in New South Wales, Australia, along with up to 24 parents/caregivers. Adolescents will participate in a 6-week virtually delivered manualised cognitive dissonance based DBP program, delivered in a group format across four cohorts of 6 adolescents. In addition, two group sessions will be developed and delivered virtually to parents/caregivers for each cohort. Outcomes will be assessed at baseline, post-intervention and at 3 and 6 months follow up. Feasibility will be evaluated through recruitment, retention, attendance, between-session activity completion and parent/caregiver uptake. Acceptability will be assessed via participant and caregiver satisfaction surveys. Preliminary efficacy will be explored through changes in disordered eating behaviors (Diabetes Eating Problem Survey-Revised), body appreciation (BAS-2), diabetes distress (PAID-T), and glycaemic outcomes. DISCUSSION: This study will evaluate the implementation of an adapted DBP intervention for adolescents with T1D within a real-world clinical service. By incorporating a novel parent/caregiver component and targeting the adolescent population, the study addresses key gaps in current literature. Findings may inform the design of future larger-scale trials and support the integration of ED prevention strategies into routine pediatric diabetes care. CI - Copyright (c) 2026 Fisher, Pursey, Leigh, King and Smart. FAU - Fisher, Emma L AU - Fisher EL AD - Paediatric Endocrinology and Diabetes, John Hunter Children's Hospital, New Lambton Heights, NSW, Australia. AD - School of Health Sciences, College of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW, Australia. FAU - Pursey, Kirrilly M AU - Pursey KM AD - School of Health Sciences, College of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. FAU - Leigh, Lucy AU - Leigh L AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. AD - School of Medicine and Public Health, College of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW, Australia. FAU - King, Bruce R AU - King BR AD - Paediatric Endocrinology and Diabetes, John Hunter Children's Hospital, New Lambton Heights, NSW, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. FAU - Smart, Carmel E AU - Smart CE AD - Paediatric Endocrinology and Diabetes, John Hunter Children's Hospital, New Lambton Heights, NSW, Australia. AD - School of Health Sciences, College of Health Medicine and Wellbeing, The University of Newcastle, Callaghan, NSW, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. LA - eng PT - Journal Article DEP - 20260928 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/psychology/complications/therapy MH - Adolescent MH - Female MH - *Feeding and Eating Disorders/prevention & control/etiology/psychology MH - Pilot Projects MH - Australia/epidemiology MH - Male MH - Cohort Studies PMC - PMC13654795 OTO - NOTNLM OT - adolescents OT - eating disorder OT - pilot OT - prevention OT - type 1 diabetes COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/13 11:41 MHDA- 2026/10/13 11:42 PMCR- 2026/09/28 CRDT- 2026/10/13 07:31 PHST- 2026/08/05 00:00 [received] PHST- 2026/09/07 00:00 [revised] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/10/13 11:42 [medline] PHST- 2026/10/13 11:41 [pubmed] PHST- 2026/10/13 07:31 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - 10.3389/fendo.2026.1958711 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 28;17:1958711. doi: 10.3389/fendo.2026.1958711. eCollection 2026. PMID- 42865446 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261014 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - A data-driven stratification framework for physical fitness in junior high school students: a composite approach based on BMI and multidimensional data. PG - 1959431 LID - 10.3389/fpubh.2026.1959431 [doi] LID - 1959431 AB - OBJECTIVE: To overcome the practical challenges of implementing differentiated instruction in large physical education (PE) classes, this study develops a composite stratification framework. This exploratory framework provides a baseline for precise, individualized physical fitness interventions in adolescents. METHODS: A quantitative cross-sectional design was employed. First, a questionnaire survey was administered to 125 primary and secondary school PE teachers in Beijing to evaluate their attitudes and preferences for evaluation indicators regarding differentiated instruction. Second, multidimensional physical fitness monitoring data were collected from 532 junior high school students. Following the standardization of continuous physical fitness test scores and categorization by Body Mass Index (BMI), one-way analysis of variance (ANOVA) and K-means clustering algorithms were comprehensively applied to explore the underlying latent cluster formations of students' multidimensional physical fitness characteristics. RESULTS: The survey revealed a high theoretical acceptance of differentiated instruction among frontline teachers, yet a "knowing-doing gap" remains in large-class settings, with 65.85% of respondents prioritizing BMI as the primary stratification criterion. ANOVA confirmed significant differences in physical fitness scores across BMI groups, validating its preliminary screening value. However, it also demonstrated that relying on a single morphological indicator easily obscures the micro-heterogeneity of unbalanced physical performance. The introduction of multidimensional data clustering successfully grouped male students into 2 clusters and female students into 3 clusters, effectively controlling pedagogical stratification tiers and intra-group variance. CONCLUSION: The composite stratification framework-integrating initial BMI screening with multidimensional physical fitness data clustering-serves as an exploratory framework for identifying heterogeneous fitness profiles. Because this study identifies statistical subgroups cross-sectionally without prospective interventions or safety monitoring, it does not constitute a validated educational strategy. Its practical pedagogical effectiveness, longitudinal stability, and safety require rigorous external validation studies. CI - Copyright (c) 2026 Fang, Hou and Wen. FAU - Fang, Yi AU - Fang Y AD - Capital University of Physical Education and Sports, Beijing, China. FAU - Hou, Juhao AU - Hou J AD - Capital University of Physical Education and Sports, Beijing, China. FAU - Wen, Shilin AU - Wen S AD - Capital University of Physical Education and Sports, Beijing, China. LA - eng PT - Journal Article DEP - 20260928 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - *Physical Fitness/physiology MH - Humans MH - *Body Mass Index MH - Cross-Sectional Studies MH - *Physical Education and Training MH - Female MH - Male MH - Adolescent MH - Clustering Algorithms MH - Surveys and Questionnaires MH - *Students/statistics & numerical data MH - Cluster Analysis MH - Beijing PMC - PMC13654965 OTO - NOTNLM OT - adolescent health OT - body mass index (BMI) OT - cluster analysis OT - differentiated instruction OT - physical fitness COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/13 11:41 MHDA- 2026/10/13 11:42 PMCR- 2026/09/28 CRDT- 2026/10/13 06:43 PHST- 2026/08/05 00:00 [received] PHST- 2026/09/04 00:00 [revised] PHST- 2026/09/10 00:00 [accepted] PHST- 2026/10/13 11:42 [medline] PHST- 2026/10/13 11:41 [pubmed] PHST- 2026/10/13 06:43 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1959431 [doi] PST - epublish SO - Front Public Health. 2026 Sep 28;14:1959431. doi: 10.3389/fpubh.2026.1959431. eCollection 2026. PMID- 42865444 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261015 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Physical activity, entertainment screen time, and dietary fat profiles and concurrent weight status among school-attending Chinese children and adolescents: CHNS 2004-2011. PG - 1945546 LID - 10.3389/fpubh.2026.1945546 [doi] LID - 1945546 AB - BACKGROUND: Physical activity, screen-based leisure, and diet co-occur, but profiles estimated from a small set of indicators may be sensitive to historical period and model assumptions. We identified profiles defined by total physical activity, reported entertainment screen time, and dietary fat contribution to energy intake in the 2004-2011 China Health and Nutrition Survey (CHNS), and examined their concurrent associations with weight status. METHODS: This pooled cross-sectional analysis included 4,112 person-wave observations from school-attending participants aged 6-17 years. A prespecified Gaussian mixture analysis compared one through six profiles. Associations with measured overweight/obesity were estimated in 4,068 observations from 2,757 participants using posterior-probability pseudo-class draws and participant-clustered robust standard errors. Wave-, age-, model-specification-, missing-data-, and alternative-outcome analyses assessed robustness. RESULTS: The prespecified model retained five profiles: very low activity (6.9%), low-to-moderate activity/lower fat (37.8%), no reported entertainment screen time (5.4%), higher fat (27.8%), and highly active (22.2%). The exact BIC-preferred number of profiles varied across survey waves, age groups, and model specifications, and 48.4% of observations had a maximum posterior probability below 0.70. The estimated prevalence of overweight/obesity, accounting for profile-membership uncertainty, was highest in the very-low-activity profile (24.4%) and was 16.4% in the reference profile. This descriptive difference attenuated after adjustment (odds ratio, 1.18; 95% confidence interval, 0.81-1.69), and the fully adjusted global profile test was non-significant (p = 0.806). Multinomial models separating overweight and obesity, continuous BMI and approximate WHO BMI-for-age z-score models, multiple imputation, and inverse-probability weighting produced the same overall conclusion. CONCLUSION: In the 2004-2011 CHNS analytic sample, the measured behaviors formed heterogeneous combinations, but the selected profiles did not independently distinguish concurrent weight status after adjustment. The findings are historical and sample-specific; they should not be interpreted as current national profile distributions or as validation of profile-based interventions. CI - Copyright (c) 2026 Qin, Wang, Zhang, Sheng, Jiang, Cheng and Wang. FAU - Qin, Boao AU - Qin B AD - School of Physical Education, Yanshan University, Qinhuangdao, China. FAU - Wang, Changyang AU - Wang C AD - School of Physical Education, Yanshan University, Qinhuangdao, China. FAU - Zhang, Yuchen AU - Zhang Y AD - School of Physical Education, Yanshan University, Qinhuangdao, China. FAU - Sheng, Linwei AU - Sheng L AD - School of Physical Education, Yanshan University, Qinhuangdao, China. FAU - Jiang, Xiaobo AU - Jiang X AD - School of Physical Education, Yanshan University, Qinhuangdao, China. FAU - Cheng, Chen AU - Cheng C AD - School of Physical Education, Yanshan University, Qinhuangdao, China. FAU - Wang, Yukuo AU - Wang Y AD - School of Physical Education, Yanshan University, Qinhuangdao, China. LA - eng GR - R01 HD030880/HD/NICHD NIH HHS/United States GR - R01 DK104371/DK/NIDDK NIH HHS/United States GR - R01 AG065357/AG/NIA NIH HHS/United States GR - R01 HL108427/HL/NHLBI NIH HHS/United States GR - D43 TW009077/TW/FIC NIH HHS/United States PT - Journal Article DEP - 20260928 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 0 (Dietary Fats) RN - Chinese people SB - IM MH - Humans MH - Child MH - *Screen Time MH - China/epidemiology MH - Adolescent MH - Female MH - Cross-Sectional Studies MH - Male MH - Nutrition Surveys MH - *Exercise MH - *Dietary Fats/administration & dosage MH - Overweight/epidemiology MH - *Body Weight MH - East Asian People PMC - PMC13654989 OTO - NOTNLM OT - China Health and Nutrition Survey OT - behavioral profiles OT - children and adolescents OT - dietary fat OT - entertainment screen time OT - latent profile analysis OT - physical activity OT - weight status COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/13 11:41 MHDA- 2026/10/13 11:42 PMCR- 2026/09/28 CRDT- 2026/10/13 06:39 PHST- 2026/07/22 00:00 [received] PHST- 2026/08/12 00:00 [revised] PHST- 2026/08/18 00:00 [accepted] PHST- 2026/10/13 11:42 [medline] PHST- 2026/10/13 11:41 [pubmed] PHST- 2026/10/13 06:39 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1945546 [doi] PST - epublish SO - Front Public Health. 2026 Sep 28;14:1945546. doi: 10.3389/fpubh.2026.1945546. eCollection 2026. PMID- 42865130 OWN - NLM STAT- Publisher LR - 20261022 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) DP - 2026 Oct 12 TI - Early lactation breast milk protein and lactose as independent predictors of infant regurgitation: A prospective cohort study. LID - 10.1002/jpn3.70600 [doi] AB - OBJECTIVES: To examine whether breast milk (BM) macronutrient composition in the first 2 weeks postpartum is associated with subsequent infant regurgitation (IR) risk, independent of maternal dietary intake. METHODS: In this prospective cohort study (Beijing, China), 78 mother-infant dyads were followed for 5 months. BM samples were collected at 1-2 weeks, 1, 2, and 5 months postpartum. IR was diagnosed using Rome IV criteria. Macronutrient composition (protein, fat, lactose) was analyzed using standardized methods. Maternal diet was assessed via a validated food frequency questionnaire. Multivariable logistic regression adjusted for maternal (body mass index, gestational age) and infant (birth weight, gender) characteristics. RESULTS: IR incidence peaked at 1 month (61.5%) and declined thereafter. Compared with controls, infants who developed IR at 1-2 months were exposed to lower protein and higher lactose concentrations in BM collected at 1-2 weeks (p < 0.05 for both). Maternal dietary intake was not associated with BM macronutrient composition. In adjusted models, lower early BM protein (odds ratio [OR] 0.090; 95% confidence interval [CI] 0.012-0.670) and higher lactose (OR 2.571; 95% CI 1.039-6.363) were associated with increased IR risk at 1 month. CONCLUSIONS: Early BM composition may be associated with subsequent IR risk, independent of maternal diet. Protein and lactose levels in early lactation may serve as potential markers for identifying infants at risk. These findings suggest early lactation as a sensitive period linking maternal physiology to infant gastrointestinal outcomes. CI - (c) 2026 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Li, Pei AU - Li P AD - School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Luhe Hospital, Capital Medical University, Beijing, China. FAU - Wu, Dan AU - Wu D AD - Beijing Luhe Hospital, Capital Medical University, Beijing, China. FAU - Jiang, Yilun AU - Jiang Y AUID- ORCID: 0009-0008-1232-0171 AD - School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Beijing, China. FAU - Lu, Shuangmei AU - Lu S AD - Beijing Luhe Hospital, Capital Medical University, Beijing, China. FAU - Peng, Jing AU - Peng J AD - Beijing Luhe Hospital, Capital Medical University, Beijing, China. FAU - Yang, Chun AU - Yang C AD - School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Beijing, China. FAU - Li, Peng-Gao AU - Li PG AUID- ORCID: 0000-0001-9134-5116 AD - School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Beijing, China. LA - eng GR - CNS-Feihe2021-42/Chinese Nutrition Society/ PT - Journal Article DEP - 20261012 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM OTO - NOTNLM OT - early life nutrition OT - gastrointestinal symptoms OT - infant feeding OT - maternal diet OT - risk factors EDAT- 2026/10/13 05:31 MHDA- 2026/10/13 05:31 CRDT- 2026/10/13 03:03 PHST- 2026/07/29 00:00 [revised] PHST- 2026/04/20 00:00 [received] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/10/13 05:31 [pubmed] PHST- 2026/10/13 05:31 [medline] PHST- 2026/10/13 03:03 [entrez] AID - 10.1002/jpn3.70600 [doi] PST - aheadofprint SO - J Pediatr Gastroenterol Nutr. 2026 Oct 12. doi: 10.1002/jpn3.70600. PMID- 42864684 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261015 IS - 2049-9957 (Electronic) IS - 2095-5162 (Print) IS - 2049-9957 (Linking) VI - 15 IP - 1 DP - 2026 Oct 12 TI - Pragmatic weight estimation for dosing of a new paediatric treatment for schistosomiasis prevention and control in preschool-aged children: a feasibility study in Uganda and Cote d'Ivoire. LID - 10.1186/s40249-026-01507-9 [doi] LID - 108 AB - BACKGROUND: Schistosomiasis remains a major public health concern in endemic settings. The Pediatric Praziquantel Consortium has developed a new paediatric treatment, arpraziquantel, for preschool-aged children. Because the treatment is dosed according to body weight, dose determination by scales poses operational challenges in community-based mass treatment campaigns. This study assessed the performance of the Pediatric Advanced Weight Prediction in the Emergency Room Extra-Long Mid-Arm Circumference (PAWPER XL-MAC) tape for weight estimation during mass drug administration in Uganda and Cote d'Ivoire. METHODS: A mixed-methods study evaluated feasibility in terms of accuracy, reliability and acceptability of the PAWPER XL-MAC tape across delivery platforms and users between March 2025 and March 2026. Accuracy metrics comprised (1) the mean relative difference and mean absolute relative difference between predicted (tape) and observed (scale) weight and (2) the proportion of estimates within 10% (PW10) and 20% (PW20) of observed weight. Reliability was evaluated by calculating the intraclass-correlation coefficient (ICC). User experiences were collected through observations, questionnaires, focus group discussions and in-depth interviews. RESULTS: In Uganda (n = 3369), mean absolute differences were 11.0-11.1%; PW10 60.2-61.0%. In Cote d'Ivoire (n = 1249), accuracy was higher (6.8-7.7%; PW10 72.4-78.2%). Reliability was high between users and countries (ICCs >/= 0.84). Sufficient time for practical training was essential to achieve solid performance. With continued use, an increase in confidence, efficiency, and accuracy was observed. Qualitative results indicated strong acceptability and practical advantages amongst users. CONCLUSIONS: This is the first study to demonstrate that the PAWPER XL-MAC tape offers reliable, accurate, and acceptable weight estimation for community-based interventions, supporting its use in routine child healthcare and public health programmes. Trial registration ClinicalTrials.gov ID NCT06698510, date of registration: 21.11.2024. CI - (c) 2026. The Author(s). FAU - Monnier, Nora AU - Monnier N AUID- ORCID: 0000-0001-5140-8549 AD - Swiss Tropical and Public Health Institute, Allschwil, Switzerland. nora.monnier@swisstph.ch. AD - University of Basel, Basel, Switzerland. nora.monnier@swisstph.ch. AD - Swiss Tropical and Public Health Institute, Kreuzstrasse 2, CH-4123, Allschwil, Switzerland. nora.monnier@swisstph.ch. FAU - Beinamaryo, Prudence AU - Beinamaryo P AD - Vector Control Division, Ministry of Health Uganda, Kampala, Uganda. FAU - Wells, Mike AU - Wells M AD - Division of Emergency Medicine, University of the Witwatersrand, Johannesburg, South Africa. AD - Jackson Memorial Hospital, Miami, FL, USA. FAU - Akoa, Agathe AU - Akoa A AD - Programme National de Nutrition, Ministere de la Sante, de l'Hygiene et de la Couverture Maladie Universelle, Abidjan, Cote d'Ivoire. FAU - Aritnaitwe, Moses AU - Aritnaitwe M AD - Vector Control Division, Ministry of Health Uganda, Kampala, Uganda. FAU - Barth-Jaeggi, Tanja AU - Barth-Jaeggi T AD - Swiss Tropical and Public Health Institute, Allschwil, Switzerland. AD - University of Basel, Basel, Switzerland. FAU - Bassa, Fidele K AU - Bassa FK AD - UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. AD - Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote d'Ivoire. FAU - Burrill, Jenny AU - Burrill J AD - Unlimit Health, London, UK. FAU - Coulibaly, Gaoussou AU - Coulibaly G AD - UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. AD - Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote d'Ivoire. FAU - Diakite, Nana R AU - Diakite NR AD - UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. AD - Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote d'Ivoire. FAU - Dje, Norbert N AU - Dje NN AD - Programme National de Lutte Contre les Maladies Tropicales Negligees a Chimiotherapie Preventive, Ministere de la Sante, de l'Hygiene Publique et de la Couverture Maladie Universelle, Abidjan, Cote d'Ivoire. FAU - Gnahore, Alexise D AU - Gnahore AD AD - Departement de Sociologie, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. FAU - Hattendorf, Jan AU - Hattendorf J AD - Swiss Tropical and Public Health Institute, Allschwil, Switzerland. AD - University of Basel, Basel, Switzerland. FAU - Hurlimann, Eveline AU - Hurlimann E AD - Swiss Tropical and Public Health Institute, Allschwil, Switzerland. AD - University of Basel, Basel, Switzerland. FAU - Kouame, Rene O AU - Kouame RO AD - Programme National de Nutrition, Ministere de la Sante, de l'Hygiene et de la Couverture Maladie Universelle, Abidjan, Cote d'Ivoire. FAU - Kouamin, Alain C AU - Kouamin AC AD - Programme National de Lutte Contre les Maladies Tropicales Negligees a Chimiotherapie Preventive, Ministere de la Sante, de l'Hygiene Publique et de la Couverture Maladie Universelle, Abidjan, Cote d'Ivoire. FAU - Kyarisiima, Hilda AU - Kyarisiima H AD - Vector Control Division, Ministry of Health Uganda, Kampala, Uganda. FAU - Lange, Isabelle L AU - Lange IL AD - Department of Neurology, TUM University Hospital and Center for Global Health, School of Medicine and Health, Technical University of Munich, Munich, Germany. AD - Department of Infectious Disease Epidemiology and International Health, London School of Hygiene & Tropical Medicine, London, UK. FAU - Lavry, Suzanne Lobohon AU - Lavry SL AD - Departement de Sociologie, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. FAU - Nabatte, Betty AU - Nabatte B AD - Vector Control Division, Ministry of Health Uganda, Kampala, Uganda. FAU - Neema, Stella AU - Neema S AD - Department of Sociology and Anthropology, Makerere University, Kampala, Uganda. FAU - N'Goran, Eliezer K AU - N'Goran EK AD - UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. AD - Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote d'Ivoire. FAU - N'Goran, Hahyat R AU - N'Goran HR AD - Programme National de Lutte Contre les Maladies Tropicales Negligees a Chimiotherapie Preventive, Ministere de la Sante, de l'Hygiene Publique et de la Couverture Maladie Universelle, Abidjan, Cote d'Ivoire. FAU - Ohouo, Ulrich AU - Ohouo U AD - Programme National de Nutrition, Ministere de la Sante, de l'Hygiene et de la Couverture Maladie Universelle, Abidjan, Cote d'Ivoire. FAU - Preston, Ashley AU - Preston A AD - UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. FAU - Roth, Laura F AU - Roth LF AD - Department of Neurology, TUM University Hospital and Center for Global Health, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Sehi Bi, Tra J AU - Sehi Bi TJ AD - Departement de Sociologie, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. FAU - Verhoeven, Dianne AU - Verhoeven D AD - Department of Neurology, TUM University Hospital and Center for Global Health, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Winkler, Andrea S AU - Winkler AS AD - Department of Neurology, TUM University Hospital and Center for Global Health, School of Medicine and Health, Technical University of Munich, Munich, Germany. AD - Department of Community Medicine and Global Health, Institute of Health and Society, University of Oslo, Oslo, Norway. FAU - Toh, Alain AU - Toh A AD - Departement de Sociologie, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. FAU - Steinmann, Peter AU - Steinmann P AD - Swiss Tropical and Public Health Institute, Allschwil, Switzerland. AD - University of Basel, Basel, Switzerland. FAU - Ouattara, Mamadou AU - Ouattara M AD - UFR Biosciences, Universite Felix Houphouet-Boigny, Abidjan, Cote d'Ivoire. AD - Centre Suisse de Recherches Scientifiques en Cote d'Ivoire, Abidjan, Cote d'Ivoire. CN - Pediatric Praziquantel Consortium LA - eng SI - ClinicalTrials.gov/NCT06698510 GR - G2020-102/Global Health Innovation Technology Fund/ GR - RIA2019IR-2895./EDCTP/ PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20261012 PL - England TA - Infect Dis Poverty JT - Infectious diseases of poverty JID - 101606645 RN - 0 (Anthelmintics) RN - 6490C9U457 (Praziquantel) SB - IM MH - Child, Preschool MH - Female MH - Humans MH - Male MH - *Anthelmintics/administration & dosage MH - *Body Weight MH - Cote d'Ivoire/epidemiology MH - Feasibility Studies MH - *Mass Drug Administration MH - *Praziquantel/administration & dosage/therapeutic use MH - Reproducibility of Results MH - *Schistosomiasis/prevention & control/drug therapy MH - Uganda/epidemiology PMC - PMC13660070 OTO - NOTNLM OT - Arpraziquantel OT - Child health OT - Implementation research OT - Neglected tropical diseases OT - Pediatric drug dosing OT - Preschool-aged children OT - Schistosomiasis OT - Weight estimation COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical principles of the Declaration of Helsinki and scientific standards for research involving human participants. The study in Uganda was approved by the Ugandan National Council for Science and Technology (UNCST, Ref: HS5146ES), the Vector Control Division Research Ethics Committee (VCDR-2024-60) and the Ethics Committee Northwest and Central Switzerland (EKNZ, AO_2024-10-00103). Authorization to conduct research in Bugiri and Hoima Districts was given by the local governments in each district. The study in Cote d'Ivoire was approved by the National Ethics Committee of Cote d'Ivoire (Comite National d'Ethique des Sciences de la Vie et de la Sante CNESVS, N/Ref: 00215-25/MSHPCMU/CNESVS-km) and EKNZ (AO_2025-00121). The social science study for pilot implementation in Uganda was approved by the Ethics Committee of the Technical University of Munich (TUM), University Hospital (TUM, 2024-394-S-CB), Germany, the Makerere University School of Social Science Research Ethics Committee (MAKSSREC 07.2024.766) and the UNCST (SS3420ES). The social science study in the large-scale study distribution in Cote d'Ivoire was approved by the Ethics Committee of TUM (2025-623-S-CT) and by the CNESVS (N/Ref: 00188-25/MSHPCMU/CNESVS-km) of Cote d'Ivoire. All participants, or the parents/legal guardians of minors, provided informed consent prior to enrolment. No biological samples were collected. Consent for publication: Not applicable. Patient and public involvement: Patients or the public were not involved in the design, or conduct, or reporting, or dissemination plans of our research. Competing interests: The authors declare no competing interests. EDAT- 2026/10/13 05:31 MHDA- 2026/10/13 05:32 PMCR- 2026/10/12 CRDT- 2026/10/13 00:47 PHST- 2026/06/02 00:00 [received] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/10/13 05:32 [medline] PHST- 2026/10/13 05:31 [pubmed] PHST- 2026/10/13 00:47 [entrez] PHST- 2026/10/12 00:00 [pmc-release] AID - 10.1186/s40249-026-01507-9 [pii] AID - 1507 [pii] AID - 10.1186/s40249-026-01507-9 [doi] PST - epublish SO - Infect Dis Poverty. 2026 Oct 12;15(1):108. doi: 10.1186/s40249-026-01507-9. PMID- 42864118 OWN - NLM STAT- In-Process LR - 20261016 IS - 2755-9734 (Electronic) IS - 2755-9734 (Linking) VI - 29 IP - 1 DP - 2026 Oct 12 TI - Psychological and anthropometric outcomes in preschool children exposed to antenatal maternal obesity: modelling of early life risk factors. LID - 10.1136/bmjment-2026-302738 [doi] LID - e302738 AB - BACKGROUND: Maternal obesity is associated with increased risk of adverse neurodevelopmental outcomes and obesity in offspring, yet their comorbidity among preschoolers and underlying mechanisms remain unclear. OBJECTIVE: To examine associations between maternal obesity in pregnancy and offspring preschool psychopathology, focusing on clinical and biological pathways. METHODS: In a cohort of 462 women with obesity in pregnancy (body mass index (BMI) >/=30 kg/m(2)) from the UK Pregnancies Better Eating and Activity Trial, followed up with their children at 3-4 years postpartum (49% boys), structural equation models assessed effects of antenatal exposures (measured at three visits) on child risk of psychopathology: maternal inflammation (by interleukin-6), glycaemia (by random glucose or gestational diabetes diagnosis), placental function (by placental growth factor) and depressive symptoms. Child outcomes were derived from the Strengths and Difficulties Questionnaire scores and psychological phenotypes from latent class analysis (LCA). Child adiposity and eating behaviours were compared across phenotypes. FINDINGS: High-risk of psychopathology was identified in 11.3% of children (boys 14.7%, girls 8%). Higher antenatal maternal depression and lower placental function predicted increased risk of psychopathology, while inflammation and glycaemia were not associated (R(2)=44.5%). LCA identified externalising (8%) and internalising (4.1%) phenotypes. An externalising phenotype was associated with higher BMI, weight-for-age z-scores and waist circumference; both phenotypes showed greater food fussiness than well-adjusted children. CONCLUSIONS: One in 10 children of women with obesity showed early risk of psychopathology, which was linked to adiposity. Antenatal maternal depression emerged as the primary risk factor, with a novel role for placental dysfunction. CLINICAL IMPLICATION: Screening for maternal depression and placental function in pregnancies affected by obesity may help reduce adverse neurodevelopmental and metabolic outcomes in offspring. FAU - Sigurdardottir, Julie AU - Sigurdardottir J AUID- ORCID: 0000-0002-7328-648X AD - Department of Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK julie.nihouarn@kcl.ac.uk. FAU - Dalrymple, Kathryn AU - Dalrymple K AD - Department of Nutritional Sciences, School of Life Course and Population Health Sciences, King's College London, London, UK. FAU - Rutherford, Mary AU - Rutherford M AD - Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. FAU - Poston, Lucilla AU - Poston L AD - Department of Women and Children's Health, School of Life Course and Population Health Sciences, King's College London, London, UK. CN - UPBEAT Consortium LA - eng PT - Journal Article DEP - 20261012 PL - England TA - BMJ Ment Health JT - BMJ mental health JID - 9918521385306676 SB - IM PMC - PMC13662093 OTO - NOTNLM OT - Attention Deficit and Disruptive Behavior Disorders OT - Child Behavior Disorders OT - Feeding and Eating Disorders of Childhood OT - Psychometrics OT - Psychopathology COIS- Competing interests: None declared. FIR - Poston, Lucilla IR - Poston L FIR - Shennan, Andrew IR - Shennan A FIR - Briley, Annette IR - Briley A FIR - Singh, Claire IR - Singh C FIR - Seed, Paul IR - Seed P FIR - Sandall, Jane IR - Sandall J FIR - Sanders, Thomas IR - Sanders T FIR - Patel, Nashita IR - Patel N FIR - Flynn, Angela IR - Flynn A FIR - Badger, Shirlene IR - Badger S FIR - Barr, Suzanne IR - Barr S FIR - Holmes, Bridget IR - Holmes B FIR - Goff, Louise IR - Goff L FIR - Hunt, Clare IR - Hunt C FIR - Filmer, Judy IR - Filmer J FIR - Fetherstone, Jeni IR - Fetherstone J FIR - Scholtz, Laura IR - Scholtz L FIR - Tarft, Hayley IR - Tarft H FIR - Lucas, Anna IR - Lucas A FIR - Tekletdadik, Tsigerada IR - Tekletdadik T FIR - Ricketts, Deborah IR - Ricketts D FIR - Gill, Carolyn IR - Gill C FIR - Ignatian, Alex Seroge IR - Ignatian AS FIR - Boylen, Catherine IR - Boylen C FIR - Adegoke, Funso IR - Adegoke F FIR - Lawley, Elodie IR - Lawley E FIR - Butler, James IR - Butler J FIR - Maitland, Rahat IR - Maitland R FIR - Vieira, Matias IR - Vieira M FIR - Pasupathy, Dharmintra IR - Pasupathy D FIR - Goff, Louise IR - Goff L FIR - Oteng-Ntim, Eugene IR - Oteng-Ntim E FIR - Khazaezadeh, Nina IR - Khazaezadeh N FIR - Demilew, Jill IR - Demilew J FIR - O'Connor, Sile IR - O'Connor S FIR - Evans, Yvonne IR - Evans Y FIR - O'Donnell, Susan IR - O'Donnell S FIR - Llera, Ari Dela IR - Llera AD FIR - Gutzwiller, Georgina IR - Gutzwiller G FIR - Hagg, Linda IR - Hagg L FIR - Robson, Stephen IR - Robson S FIR - Bell, Ruth IR - Bell R FIR - Hayes, Louise IR - Hayes L FIR - Kinnunen, Tarja IR - Kinnunen T FIR - McParlin, Catherine IR - McParlin C FIR - Miller, Nicola IR - Miller N FIR - Kimber, Alison IR - Kimber A FIR - Riches, Jill IR - Riches J FIR - Allen, Carly IR - Allen C FIR - Boag, Claire IR - Boag C FIR - Campbell, Fiona IR - Campbell F FIR - Fenn, Andrea IR - Fenn A FIR - Ritson, Sarah IR - Ritson S FIR - Rennie, Alison IR - Rennie A FIR - Durkin, Robin IR - Durkin R FIR - Gills, Gayle IR - Gills G FIR - Carr, Roger IR - Carr R FIR - Nelson, Scott IR - Nelson S FIR - Sattar, Naveed IR - Sattar N FIR - McSorley, Therese IR - McSorley T FIR - Alba, Hilary IR - Alba H FIR - Paterson, Kirsteen IR - Paterson K FIR - Johnston, Janet IR - Johnston J FIR - Clements, Suzanne IR - Clements S FIR - Fernon, Maxine IR - Fernon M FIR - Bett, Savannah IR - Bett S FIR - Rooney, Laura IR - Rooney L FIR - Miller, Sinead IR - Miller S FIR - Welsh, Paul IR - Welsh P FIR - Cherry, Lynn IR - Cherry L FIR - Whitworth, Melissa IR - Whitworth M FIR - Patterson, Natalie IR - Patterson N FIR - Lee, Sarah IR - Lee S FIR - Grimshaw, Rachel IR - Grimshaw R FIR - Hughes, Christine IR - Hughes C FIR - Brown, Jay IR - Brown J FIR - Hinshaw, Kim IR - Hinshaw K FIR - Campbell, Gillian IR - Campbell G FIR - Knight, Joanne IR - Knight J FIR - Farrar, Diane IR - Farrar D FIR - Jones, Vicky IR - Jones V FIR - Butterfield, Gillian IR - Butterfield G FIR - Syson, Jennifer IR - Syson J FIR - Eadle, Jennifer IR - Eadle J FIR - Wood, Dawn IR - Wood D FIR - Todd, Merane IR - Todd M FIR - Khalil, Asma IR - Khalil A FIR - Brown, Deborah IR - Brown D FIR - Fernandez, Paola IR - Fernandez P FIR - Cousins, Emma IR - Cousins E FIR - Smith, Melody IR - Smith M FIR - Wardle, Jane IR - Wardle J FIR - Croker, Helen IR - Croker H FIR - Broomfield, Laura IR - Broomfield L FIR - Concern, Weight IR - Concern W FIR - Godfrey, Keith IR - Godfrey K FIR - Robinson, Sian IR - Robinson S FIR - Canadine, Sarah IR - Canadine S FIR - Greenwood, Lynne IR - Greenwood L EDAT- 2026/10/13 00:16 MHDA- 2026/10/13 00:16 PMCR- 2026/10/12 CRDT- 2026/10/12 21:42 PHST- 2026/03/31 00:00 [received] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/13 00:16 [medline] PHST- 2026/10/13 00:16 [pubmed] PHST- 2026/10/12 21:42 [entrez] PHST- 2026/10/12 00:00 [pmc-release] AID - bmjment-2026-302738 [pii] AID - 10.1136/bmjment-2026-302738 [doi] PST - epublish SO - BMJ Ment Health. 2026 Oct 12;29(1):e302738. doi: 10.1136/bmjment-2026-302738. PMID- 42863993 OWN - NLM STAT- Publisher LR - 20261012 IS - 1349-9092 (Electronic) IS - 0917-5040 (Linking) DP - 2026 Oct 9 TI - Relative Validity of Nutrient and Food Group Intakes Estimated From the Brief-type Self-administered Dietary History Questionnaire for Japanese Preschool Children Aged 3-6 Years (BDHQ3y). LID - 10.2188/jea.JE20250707 [doi] AB - BACKGROUND: To evaluate the relative validity of nutrient and food group intakes estimated using the brief-type self-administered Diet History Questionnaire for Japanese preschool children aged 3-6 years (BDHQ3y). METHODS: This study included 500 children (253 boys and 247 girls) aged 3-6 years recruited from 32 prefectures in Japan. Guardians completed the BDHQ3y to report their child's dietary intake over the previous month and then 8-day weighed dietary records (DRs) over a year (2 days per season). From the BDHQ3y and DRs, energy-adjusted intakes of 44 nutrients and 26 food groups were estimated based on the density method. RESULTS: Percentage differences in median intakes were within 10% for 26 nutrients (most energy-providing nutrients and several vitamins and minerals) and three food groups (cereals, fish/shellfish and milk/dairy products). The median Spearman's rank correlation coefficients were 0.31 (interquartile range [IQR], 0.23-0.40) for nutrients and 0.32 (IQR, 0.23-0.41) for food groups. Correlations exceeded 0.40 for 11 nutrients (eg, added sugar, dietary fiber and calcium) and nine food groups (eg, vegetables, fruits and milk/dairy products). Bland-Altman plots showed wide limits of agreement, with overestimation of intakes of protein, fats, carbohydrates, fruits, and milk/dairy products, as well as underestimation of intake of vegetables at higher intake levels. Similar findings were made when boys and girls were analyzed separately. CONCLUSION: The BDHQ3y has the potential to monitor population-level intakes of a range of nutrients. However, its utility for ranking individuals and assessing individual-level intake remains limited, requiring cautious interpretation and application. FAU - Tajima, Ryoko AU - Tajima R AUID- ORCID: 0000-0002-7799-3958 AD - Department of Nutritional Epidemiology and Behavioral Nutrition, Graduate School of Medicine, the University of Tokyo. FAU - Okubo, Hitomi AU - Okubo H AD - Department of Nutritional Epidemiology and Behavioral Nutrition, Graduate School of Medicine, the University of Tokyo. FAU - Shinozaki, Nana AU - Shinozaki N AD - Department of Social and Preventive Epidemiology, School of Public Health, the University of Tokyo. FAU - Masayasu, Shizuko AU - Masayasu S AD - Ikurien-naka. FAU - Sasaki, Satoshi AU - Sasaki S AD - Department of Social and Preventive Epidemiology, School of Public Health, the University of Tokyo. FAU - Murakami, Kentaro AU - Murakami K AD - Department of Social and Preventive Epidemiology, School of Public Health, the University of Tokyo. LA - eng PT - Journal Article DEP - 20261009 PL - Japan TA - J Epidemiol JT - Journal of epidemiology JID - 9607688 SB - IM OTO - NOTNLM OT - Japanese OT - diet history questionnaire OT - food and nutrient intake OT - preschool children OT - relative validity EDAT- 2026/10/13 00:16 MHDA- 2026/10/13 00:16 CRDT- 2026/10/12 21:23 PHST- 2026/10/13 00:16 [medline] PHST- 2026/10/13 00:16 [pubmed] PHST- 2026/10/12 21:23 [entrez] AID - 10.2188/jea.JE20250707 [doi] PST - aheadofprint SO - J Epidemiol. 2026 Oct 9. doi: 10.2188/jea.JE20250707. PMID- 42863668 OWN - NLM STAT- Publisher LR - 20261016 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 76 DP - 2026 Oct 12 TI - Anabolic responsiveness in critically ill children: A narrative review and conceptual perspective on nutrient utilization and muscle response. PG - 105189 LID - S2405-4577(26)02286-2 [pii] LID - 10.1016/j.clnesp.2026.105189 [doi] AB - Critical illness alters energy metabolism, substrate use, and protein turnover in children, while skeletal muscle loss may continue despite apparently adequate energy and protein delivery. Nutritional adequacy may depend not only on nutrient delivery but also on how effectively nutrients are utilized to preserve muscle and support anabolic responsiveness. This hypothesis-generating narrative review synthesizes evidence on metabolic alterations and anabolic responsiveness in critically ill children, focusing on indirect calorimetry, respiratory quotient (RQ), non-protein RQ (npRQ), nitrogen balance, and quadriceps and diaphragm ultrasound. PubMed/MEDLINE was searched from inception to July 2026, prioritizing pediatric evidence and incorporating adult studies when pediatric data were insufficient. Indirect calorimetry remains the reference bedside method for measuring resting energy expenditure but cannot determine whether nutrients are incorporated into skeletal muscle protein. RQ and npRQ provide information on whole-body substrate oxidation but lack validated pediatric thresholds. Nitrogen balance estimates whole-body protein retention or loss but does not directly reflect skeletal muscle protein balance. Serial ultrasound can track regional muscle changes, although quadriceps and diaphragm measurements reflect different physiological influences. Pediatric studies demonstrate early peripheral muscle loss, while direct measurements of muscle protein synthesis and breakdown remain limited. No routinely available bedside method can directly assess anabolic responsiveness or confirm anabolic resistance. Integrating metabolic measurements with serial muscle assessment may identify mismatches between nutrient delivery and tissue response but remains hypothesis-generating. Prospective studies incorporating direct protein kinetics are needed to determine when anabolic responsiveness is restored and whether this can guide nutritional and rehabilitation strategies. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Giannakopoulou, Ioulia AU - Giannakopoulou I AD - Pediatric Intensive Care Unit, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Greece. FAU - Ilia, Stavroula AU - Ilia S AD - Pediatric Intensive Care Unit, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Greece. FAU - Briassoulis, George AU - Briassoulis G AD - Pediatric Intensive Care Unit, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Greece. FAU - Raissaki, Maria AU - Raissaki M AD - Division of Radiology, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Greece. FAU - Kozana, Androniki AU - Kozana A AD - Division of Radiology, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Greece. FAU - Filippatos, Filippos AU - Filippatos F AD - Division of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Greece. FAU - Kakleas, Konstantinos AU - Kakleas K AD - Division of Pediatrics, School of Medicine, National and Kapodistrian University of Athens, Greece. FAU - Miliaraki, Marianna AU - Miliaraki M AD - Pediatric Intensive Care Unit, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Greece. Electronic address: mmiliaraki@uoc.gr. LA - eng PT - Journal Article PT - Review DEP - 20261012 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM OTO - NOTNLM OT - Anabolic resistance OT - Indirect calorimetry OT - Mechanical ventilation OT - Muscle ultrasound OT - Nitrogen balance OT - Pediatric intensive care COIS- Conflicts of interest The authors declare no conflicts of interest. EDAT- 2026/10/13 00:16 MHDA- 2026/10/13 00:16 CRDT- 2026/10/12 19:33 PHST- 2026/08/20 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/10/06 00:00 [accepted] PHST- 2026/10/13 00:16 [pubmed] PHST- 2026/10/13 00:16 [medline] PHST- 2026/10/12 19:33 [entrez] AID - S2405-4577(26)02286-2 [pii] AID - 10.1016/j.clnesp.2026.105189 [doi] PST - aheadofprint SO - Clin Nutr ESPEN. 2026 Oct 12;76:105189. doi: 10.1016/j.clnesp.2026.105189. PMID- 42862150 OWN - NLM STAT- Publisher LR - 20261012 IS - 0272-9490 (Print) IS - 0272-9490 (Linking) DP - 2026 Oct 12 TI - Lifestyle Documentation in Therapy Evaluations for Autistic Children: A Lexicon-Based Analysis of Electronic Health Records. PG - 19437676261493019 LID - 10.1177/19437676261493019 [doi] AB - BackgroundWhole person health (WPH) is a multidimensional construct encompassing, physical, and mental health along with relational constructs such as social health that are deeply tied to well-being. Autistic individuals report an overall lower quality of life, but the extent to which these issues are addressed during therapy evaluations has not been examined systematically.MethodologyIn this retrospective, cross-sectional study, we employ a rule-based NLP/lexicon-based approach to examine the areas of focus of therapy evaluations documented by occupational therapy, physical therapy (PT), and speech-language pathology (SLP) professionals. Using electronic health records for children aged 2 to 18 diagnosed with autism spectrum disorder (ASD) (n = 5619 evaluation reports of n = 2021 unique patients), we classified health records based on the domains addressed.ResultsAcross notes, nutrition had the highest average degree of documentation (M = 2.14), compared to activity (M = 0.91), followed by wellness (M = 0.66), and sleep (M = 0.39). In occupational therapy, wellness was the most common (77.62% of notes), followed by physical activity (76.49% of notes), nutrition management (73.33% of notes), and sleep (34.97% of notes). The overall area under the curve (AUC) from the receiver operating characteristic analysis is 0.89.ConclusionsWhile it is encouraging that most evaluations addressed nutrition or physical activity, the near absence of attention to sleep represents a critical gap in care. Given sleep's foundational role in overall health and daily functioning, its omission is particularly concerning. Occupational therapists and interdisciplinary rehabilitation teams should more deliberately integrate WPH frameworks into their evaluations. FAU - Dallman, Aaron R AU - Dallman AR AUID- ORCID: 0000-0001-6975-5581 AD - Department of Rehabilitation and Movement Sciences, Rutgers Health School of Health Professions, New Brunswick, USA. RINGGOLD: 242612 FAU - Santucci, Gregory AU - Santucci G AD - Children's Specialized Hospital, New Brunswick, USA. RINGGOLD: 507831 FAU - Lai, Diana AU - Lai D AD - Children's Specialized Hospital, New Brunswick, USA. RINGGOLD: 507831 FAU - Welch, Caroline AU - Welch C AD - Department of Rehabilitation and Movement Sciences, Rutgers Health School of Health Professions, New Brunswick, USA. RINGGOLD: 242612 FAU - Jimenez, Manuel E AU - Jimenez ME AD - Children's Specialized Hospital, New Brunswick, USA. RINGGOLD: 507831 AD - Rutgers Robert Wood Johnson Medical School, New Brunswick, USA. LA - eng PT - Journal Article DEP - 20261012 PL - United States TA - Am J Occup Ther JT - The American journal of occupational therapy : official publication of the American Occupational Therapy Association JID - 7705978 SB - IM OAB - Many Autistic people face challenges that can affect their overall well-being and quality of life. In this study, we reviewed evaluation reports from Autistic children in a large health system. We looked at how these reports addressed key areas of whole-person health, including physical activity, sleep, nutrition, and overall wellness. We found that nutrition was the most addressed area, followed by physical activity, sleep, and wellness. While it is encouraging that many evaluations included nutrition and physical activity, very few addressed sleep. This is an important gap, given how essential sleep is for health and daily functioning. We believe rehabilitation clinicians should routinely ask about sleep as part of their evaluations. We also suggest that evaluation reports can be a valuable tool for identifying gaps in care and should be used more often to improve health system practices. OABL- eng OTO - NOTNLM OT - Whole person health OT - autism spectrum disorder OT - learning health system OT - pediatric occupational therapy OT - secondary data analysis EDAT- 2026/10/12 11:41 MHDA- 2026/10/12 11:41 CRDT- 2026/10/12 10:33 PHST- 2026/10/12 11:41 [medline] PHST- 2026/10/12 11:41 [pubmed] PHST- 2026/10/12 10:33 [entrez] AID - 10.1177/19437676261493019 [doi] PST - aheadofprint SO - Am J Occup Ther. 2026 Oct 12:19437676261493019. doi: 10.1177/19437676261493019. PMID- 42861918 OWN - NLM STAT- Publisher LR - 20261012 IS - 1941-9260 (Electronic) IS - 0032-5481 (Linking) DP - 2026 Oct 12 TI - Toward consensus on complementary feeding recommendations: findings from a national evidence-informed modified Delphi study in Turkiye. PG - 1-12 LID - 10.1080/00325481.2026.2745217 [doi] AB - BACKGROUND: Complementary feeding (CF) recommendations are generally based on international guidelines; however, several clinical issues remain controversial, resulting in variability in professional practice. This study aimed to develop evidence-informed expert consensus on complementary feeding recommendations and to explore the reasons underlying persistent disagreement. METHODS: In this national evidence-informed modified Delphi study in Turkiye, 58 pediatricians working in Social Pediatrics participated in the first round and evaluated 53 statements using a five-point Likert scale. Statements not reaching consensus were revised based on participants' comments and reevaluated in a second round. Thirteen unresolved statements underwent a third round involving evidence presentation and structured online discussion with 23 participants; 22 subsequently completed the final re-rating. Audio-recorded discussions and written comments were analyzed using reflexive thematic analysis in MAXQDA Analytics Pro 24. RESULTS: Consensus was achieved for most recommendations regarding the timing of CF, developmental readiness, responsive feeding, and several feeding practices. Persistent disagreement remained for recommendations concerning formula-fed infants, infants with poor weight gain, preterm infants, baby-led weaning (BLW), vegan CF, bottle use, and selected allergy-related practices. Qualitative analysis generated five overarching themes: (1) individualization beyond fixed age thresholds; (2) balancing nutritional priorities with developmental safety and feasibility; (3) risk-stratified introduction of allergenic foods; (4) conditional rather than universal acceptance of BLW; and (5) ethical and clinical tensions surrounding vegan CF. Experts generally agreed on the underlying scientific principles but emphasized that recommendations should incorporate developmental readiness, clinical judgment, family circumstances, cultural context, and implementation feasibility rather than relying on rigid or universal recommendations. CONCLUSIONS: Integration of quantitative Delphi findings with qualitative thematic analysis revealed that non-consensus primarily stemmed from the practical nuances of clinical execution and contextual adaptation, rather than a fundamental skepticism toward the underlying scientific data. These findings provide an evidence-informed foundation for developing context-sensitive CF recommendations for clinical practice. FAU - Yalcin, Siddika Songul AU - Yalcin SS AUID- ORCID: 0000-0001-9061-4281 AD - Department of Pediatrics, Division of Social Pediatrics, Hacettepe University Faculty of Medicine, Ankara, Turkiye. FAU - Ozboru Askan, Oyku AU - Ozboru Askan O AUID- ORCID: 0000-0002-4139-5497 AD - Faculty of Medicine, Department of Pediatrics, Istanbul Atlas University, Istanbul, Turkiye. FAU - Barutcu, Adnan AU - Barutcu A AUID- ORCID: 0000-0001-8930-1122 AD - Department of Pediatrics, Division of Social Pediatrics, Cukurova University Faculty of Medicine, Adana, Turkiye. FAU - Almis, Habip AU - Almis H AUID- ORCID: 0000-0001-9327-4876 AD - Sincan Training and Research Hospital, Department of Pediatrics, Division of Social Pediatrics, University of Health Sciences, Ankara, Turkiye. FAU - Orun, Emel AU - Orun E AUID- ORCID: 0000-0002-7596-5603 AD - Etlik City Hospital, Department of Pediatrics, Division of Social Pediatrics, University of Health Sciences, Ankara, Turkiye. FAU - Camurdan, Aysu Duyan AU - Camurdan AD AUID- ORCID: 0000-0001-8384-7423 AD - Department of Social Pediatrics, Gazi University Faculty of Medicine, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20261012 PL - England TA - Postgrad Med JT - Postgraduate medicine JID - 0401147 SB - IM OTO - NOTNLM OT - Complementary feeding OT - Delphi study OT - baby-led weaning OT - consensus OT - food allergy OT - thematic analysis OT - vegan diet EDAT- 2026/10/12 11:41 MHDA- 2026/10/12 11:41 CRDT- 2026/10/12 08:35 PHST- 2026/10/12 11:41 [medline] PHST- 2026/10/12 11:41 [pubmed] PHST- 2026/10/12 08:35 [entrez] AID - 10.1080/00325481.2026.2745217 [doi] PST - aheadofprint SO - Postgrad Med. 2026 Oct 12:1-12. doi: 10.1080/00325481.2026.2745217. PMID- 42861858 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261023 IS - 1552-4604 (Electronic) IS - 0091-2700 (Print) IS - 0091-2700 (Linking) VI - 66 IP - 10 DP - 2026 Oct TI - Development and Evaluation of a Population Pharmacokinetic Model for High-Dose Methotrexate in Japanese Pediatric Patients with Acute Lymphoblastic Leukemia. PG - e70310 LID - 10.1002/jcph.70310 [doi] LID - e70310 AB - Methotrexate is a key chemotherapeutic agent for treating pediatric acute lymphoblastic leukemia (ALL); however, its pharmacokinetics exhibit substantial inter-individual variability. Population pharmacokinetic (PPK) models have identified body weight and renal function as major determinants of methotrexate clearance. Nonetheless, the optimal PPK model for Japanese pediatric patients, considering hydration status, has not yet been established. This study aimed to develop a PPK model of high-dose methotrexate specifically for Japanese pediatric patients with ALL. A retrospective PPK analysis was performed in pediatric patients with ALL, who were treated with high-dose methotrexate at the Tokyo Medical and Dental University Hospital. Data from 38 patients (504 methotrexate concentrations; 27 for model development and 11 for validation) were analyzed using a two-compartment model in NONMEM. Predictive performances of the newly developed and previously published models were assessed using the validation dataset. In the final model, clearance was described as a function of body surface area and hydration volume rate per body surface area (HYDR), whereas intercompartmental clearance was associated with age and HYDR. Evaluation using the validation dataset showed that the developed model had the best predictive performance among the evaluated models (median prediction error, 1.79%; median absolute prediction error, 13.3%; percentage of predictions with an absolute prediction error 69% cell viability at 1000 mug mL(-1) for curry leaves and coriander formulations. Tablets exhibited satisfactory pharmaceutical parameters including low friability (< 0.3%), uniform weight (1.84-2.01 g), and rapid disintegration (121-128 s). CONCLUSION: The developed iron-fortified chutney tablets reconstitute easily into chutney as a ready-to-use (RTU) product, combining nutritional value, and enhanced iron bioavailability. These findings establish the feasibility of transforming traditional food matrices into standardized iron-fortified tablets, offering a dietary supplement approach for addressing micronutrient deficiencies in vulnerable populations through indigenous food-based interventions. (c) 2026 Society of Chemical Industry. CI - (c) 2026 Society of Chemical Industry. FAU - Krishna, Ram AU - Krishna R AUID- ORCID: 0009-0006-6482-3550 AD - Department of Food Engineering and Technology, Sant Longowal Institute of Engineering and Technology, Longowal, India. FAU - Prasad, Kamlesh AU - Prasad K AUID- ORCID: 0000-0001-7086-9391 AD - Department of Food Engineering and Technology, Sant Longowal Institute of Engineering and Technology, Longowal, India. LA - eng PT - Journal Article DEP - 20261011 PL - England TA - J Sci Food Agric JT - Journal of the science of food and agriculture JID - 0376334 SB - IM OTO - NOTNLM OT - cytotoxicity OT - in vitro bioavailability OT - instant chutney tablet OT - iron fortification OT - morphological properties EDAT- 2026/10/12 05:32 MHDA- 2026/10/12 05:32 CRDT- 2026/10/12 01:24 PHST- 2026/06/15 00:00 [revised] PHST- 2026/01/14 00:00 [received] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/12 05:32 [medline] PHST- 2026/10/12 05:32 [pubmed] PHST- 2026/10/12 01:24 [entrez] AID - 10.1002/jsfa.71166 [doi] PST - aheadofprint SO - J Sci Food Agric. 2026 Oct 11. doi: 10.1002/jsfa.71166. PMID- 42859602 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261011 LR - 20261012 IS - 1178-2390 (Print) IS - 1178-2390 (Electronic) IS - 1178-2390 (Linking) VI - 19 DP - 2026 TI - Development and Expert Validation of a Hospital-to-Home Care Pathway for Preterm Infants in Indonesia: A Qualitative and Delphi Study. PG - 639379 LID - 10.2147/JMDH.S639379 [doi] LID - 639379 AB - PURPOSE: The transition of preterm infants from hospital to home requires coordinated care across hospital, primary care, community, and family settings. This study aimed to develop and validate a Hospital-to-Home Care Pathway for preterm infants in Indonesia. PATIENTS AND METHODS: A sequential exploratory qualitative-Delphi consensus design was used. This study was conducted in Bandung, West Java, Indonesia, from May 2025 to November 2025. Stage 1 involved 70 stakeholders, including mothers, healthcare providers, community health volunteers (cadres), managers, hospital leaders, and health office representatives. Data were collected through focus group discussions, in-depth interviews, observations, and document review and analyzed using inductive thematic analysis. Stage 2 used three Delphi rounds with seven experts to refine and validate the pathway. RESULTS: Stage 1 identified fragmentation across care settings beyond parental knowledge gaps. Synthesized findings yielded six pathway needs: parental readiness, information continuity, hospital-community coordination, defined roles for community health volunteers and primary care providers, community follow-up, and monitoring, evaluation, and referral feedback. Stage 2 confirmed expert consensus. Round 1 agreement ranged from 85.7% to 100%. In Round 2, item-level content validity ranged from 0.86 to 1.00, with scale-level content validity index based on average agreement (S-CVI/Ave) = 0.99 and scale-level content validity index based on universal agreement (S-CVI/UA) = 0.90. Round 3 confirmed final consensus and response stability. The final pathway comprised a visual care flow and an operational table specifying care settings, components, activities, responsible providers, and documents. CONCLUSION: This study produced an expert-validated Hospital-to-Home Care Pathway for preterm infants in Indonesia. The pathway integrates discharge planning, community follow-up, family education, documentation, and referral feedback. As a pre-implementation output, the pathway should be evaluated further through feasibility, acceptability, fidelity, and effectiveness testing before claims about clinical or health-system impact are made. CI - (c) 2026 Kamila et al. FAU - Kamila, Lia AU - Kamila L AUID- ORCID: 0009-0004-3153-3659 AD - Doctoral Study Program in Medical Science, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia. AD - Faculty of Midwifery, Institut Kesehatan Rajawali, Bandung, West Java, Indonesia. FAU - Susanti, Ari Indra AU - Susanti AI AUID- ORCID: 0000-0001-6638-5992 AD - Midwifery Program, Vocational School, Universitas Padjadjaran, Sumedang, West Java, Indonesia. FAU - Wiwaha, Guswan AU - Wiwaha G AUID- ORCID: 0000-0002-2514-7493 AD - Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia. FAU - Hilmanto, Dany AU - Hilmanto D AUID- ORCID: 0000-0003-3684-4144 AD - Department of Pediatrics, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia. LA - eng PT - Journal Article DEP - 20261004 PL - New Zealand TA - J Multidiscip Healthc JT - Journal of multidisciplinary healthcare JID - 101512691 PMC - PMC13652962 OAB - Why was this study done? Preterm infants often need continued support after hospital discharge, while parents may feel unprepared to provide care at home. In Indonesia, post-discharge care involves hospitals, primary healthcare centers, community health posts, community health volunteers, and families, but communication and follow-up are not always well coordinated. This study aimed to develop a structured pathway to support the transition of preterm infants from hospital to home. What did the researchers do? The researchers collected data from 70 stakeholders, including mothers, healthcare providers, community health volunteers, managers, hospital leaders, and health office representatives. Interviews, focus group discussions, observations, and document review were used to identify care needs and service gaps. The findings were used to develop a preliminary Hospital-to-Home Care Pathway, which was then validated through three Delphi rounds with seven experts. What did we find? The main challenge was not only whether parents had enough knowledge. The larger problem was fragmented care between hospitals, primary care, community services, and home. The final pathway includes discharge preparation, parent education, home visits, breastfeeding and nutrition support, growth and developmental monitoring, family education, documentation, and referral feedback. What does this mean? The pathway explains the sequence of care, who is responsible, when follow-up should occur, and which documents are needed. The next step is to pilot test the pathway to assess whether it can be used in routine practice, whether it is acceptable to families and healthcare providers, whether the planned activities can be carried out as intended, and what benefits it may have for infants, families, and health services. OABL- eng OTO - NOTNLM OT - community health workers OT - continuity of care OT - discharge planning OT - neonatal follow-up OT - parental readiness OT - primary healthcare COIS- The authors declare that they have no competing interests or potential conflicts of interest related to this study. EDAT- 2026/10/11 05:38 MHDA- 2026/10/11 05:39 PMCR- 2026/10/04 CRDT- 2026/10/11 04:17 PHST- 2026/07/10 00:00 [received] PHST- 2026/09/27 00:00 [accepted] PHST- 2026/10/11 05:39 [medline] PHST- 2026/10/11 05:38 [pubmed] PHST- 2026/10/11 04:17 [entrez] PHST- 2026/10/04 00:00 [pmc-release] AID - 639379 [pii] AID - 10.2147/JMDH.S639379 [doi] PST - epublish SO - J Multidiscip Healthc. 2026 Oct 4;19:639379. doi: 10.2147/JMDH.S639379. eCollection 2026. PMID- 42859262 OWN - NLM STAT- MEDLINE DCOM- 20261011 LR - 20261013 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 11 DP - 2026 Oct 10 TI - Primary care and idiopathic scoliosis: an evaluation of family physicians' roles. LID - 828 [pii] LID - 10.1007/s00431-026-07484-3 [doi] AB - Idiopathic scoliosis (IS) can progress silently during growth. Early primary care detection prevents curve progression and reduces treatment burden. This study aimed to assess the role of family physicians in screening, diagnosis, counseling, and follow-up of adolescents with IS, and to evaluate primary care attributes using the Primary Care Assessment Survey (PCAS). This cross-sectional study included 150 patients with IS followed at a university orthopedics clinic in Turkiye. Data were collected via structured telephone interviews using a custom 13-item questionnaire and the validated Turkish PCAS. Descriptive statistics and bivariate parametric and non-parametric tests were used for the analysis (p < 0.05). Only 11% of participants were first diagnosed by family physicians, whereas 68% were diagnosed by orthopedic surgeons. Primary care involvement was low: scoliosis-focused examination (15%), counseling (15%), referral (15%), and exercise recommendations (19%) were infrequent. PCAS scores were highest for longitudinal continuity (79 +/- 20) and trust (63 +/- 12), and lowest for preventive services and counseling (44 +/- 35). Late-onset scoliosis was associated with significantly higher scores in comprehensive knowledge, physical care, personal approach, accessibility, and communication (p < 0.05). CONCLUSION: Most patients with IS are diagnosed outside primary care, highlighting a substantial underutilization of opportunistic screening and early clinical evaluation in primary care settings. Standardizing scoliosis screening during routine adolescent well-visits, enhancing primary care awareness and guidance, and strengthening referral pathways are crucial for enabling earlier detection, modifying disease progression, and mitigating long-term clinical burdens. WHAT IS KNOWN: * Early detection of idiopathic scoliosis (IS) through opportunistic screening prevents curve progression, avoids invasive surgeries, and reduces long-term healthcare burdens.. WHAT IS NEW: * Only 11% of IS patients are diagnosed in primary care, revealing critical gaps in screening, posture examination, and counseling despite high longitudinal trust in family physicians.. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Tukel, Filiz Yildiz AU - Tukel FY AD - Department of Family Medicine, Faculty of Medicine, Dokuz Eylul University, Balcova, Izmir, 35330, Turkey. FAU - Come, Ogulcan AU - Come O AUID- ORCID: 0000-0002-6624-832X AD - Department of Family Medicine, Faculty of Medicine, Dokuz Eylul University, Balcova, Izmir, 35330, Turkey. ogulcancome@gmail.com. FAU - Limnili, Gizem AU - Limnili G AD - Department of Family Medicine, Faculty of Medicine, Dokuz Eylul University, Balcova, Izmir, 35330, Turkey. FAU - Gokdemir, Ozden AU - Gokdemir O AD - Department of Family Medicine, Faculty of Medicine, Ekonomi University, Izmir, Turkey. FAU - Ozcakar, Nilgun AU - Ozcakar N AD - Department of Family Medicine, Faculty of Medicine, Dokuz Eylul University, Balcova, Izmir, 35330, Turkey. LA - eng PT - Journal Article DEP - 20261010 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Scoliosis/diagnosis/therapy MH - Cross-Sectional Studies MH - Female MH - *Primary Health Care/statistics & numerical data MH - Male MH - Adolescent MH - *Physician's Role MH - Surveys and Questionnaires MH - *Physicians, Family MH - Turkey MH - Child OTO - NOTNLM OT - Adolescent idiopathic scoliosis OT - Counseling OT - Family physician OT - Preventive health OT - Primary care OT - Screening COIS- Declarations. Competing interests: The authors declare no competing interests. Declaration of generative AI and AI-assisted technologies: During the preparation of this work, the author(s) used ChatGPT-4o (OpenAI, 2025) in order to improve grammar, language clarity, and phrasing. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the publication. EDAT- 2026/10/11 05:38 MHDA- 2026/10/11 05:39 CRDT- 2026/10/10 23:41 PHST- 2026/05/13 00:00 [received] PHST- 2026/10/01 00:00 [accepted] PHST- 2026/09/25 00:00 [revised] PHST- 2026/10/11 05:39 [medline] PHST- 2026/10/11 05:38 [pubmed] PHST- 2026/10/10 23:41 [entrez] AID - 10.1007/s00431-026-07484-3 [pii] AID - 10.1007/s00431-026-07484-3 [doi] PST - epublish SO - Eur J Pediatr. 2026 Oct 10;185(11):828. doi: 10.1007/s00431-026-07484-3. PMID- 42859217 OWN - NLM STAT- Publisher LR - 20261010 IS - 1432-1971 (Electronic) IS - 0172-0643 (Linking) DP - 2026 Oct 10 TI - Physical Activity Counselling for Children with Congenital Heart Disease: A Pilot Study. LID - 10.1007/s00246-026-04469-9 [doi] AB - It is still not known how to best help children with congenital heart disease (CHD) be more active despite many previous interventions. This study aimed to determine the feasibility and acceptability of a theoretically-based physical activity (PA) counselling intervention. This is a mixed-methods pilot study of children ages 9-12 with moderate-to-complex CHD. A 12-week intervention based on behaviour change theory was designed. Participants who did not meet the World Health Organization PA guidelines (measured via accelerometers) and expressed readiness to change (measured via questionnaires) at baseline qualified. The intervention consisted of six virtual sessions with a PA counsellor, during which participants engaged in workbook activities to learn strategies to engage in PA. Intervention feasibility (recruitment, retention, completion of measures, remote implementation, session and intervention length) and acceptability (compliance, interview feedback) were assessed. PA was measured post-intervention and one year later. Thirty-three children were recruited (recruitment success: 51%). Nine out of 12 eligible participants completed the intervention (retention: 75%) with few technical difficulties (14.5%). Completion rates of PA metrics declined over the study. It took the PA counsellor 15.5 h on average per participant to conduct the intervention. Compliance was high (attendance: 100%, workbook activity completion: 64.4%). During feedback interviews, participants denoted the importance of engaging the whole family, promoting participant autonomy and empowerment, and identified lessons learned. Although this intervention was acceptable to children with CHD, the feasibility remains uncertain given recruitment challenges and time commitment required. Successful components should be considered when designing future interventions. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Fukakusa, Bianca M AU - Fukakusa BM AD - Division of Cardiology, Department of Pediatrics, British Columbia Children's Hospital, Vancouver, BC, Canada. FAU - Bennett, Erica V AU - Bennett EV AD - School of Kinesiology, Faculty of Education, University of British Columbia, Vancouver, BC, Canada. FAU - Voss, Christine AU - Voss C AD - Centre for Chronic Disease Prevention and Management, Faculty of Medicine, University of British Columbia, Kelowna, BC, Canada. FAU - Harris, Kevin C AU - Harris KC AD - Division of Cardiology, Department of Pediatrics, British Columbia Children's Hospital, Vancouver, BC, Canada. kharris2@cw.bc.ca. AD - Children's Heart Centre, BC Children's Hospital, 1F3-4480 Oak Street, Vancouver, BC, V6H 3V4, Canada. kharris2@cw.bc.ca. LA - eng PT - Journal Article DEP - 20261010 PL - United States TA - Pediatr Cardiol JT - Pediatric cardiology JID - 8003849 SB - IM OTO - NOTNLM OT - Congenital heart disease OT - Feasibility OT - Intervention OT - Physical activity OT - Pilot study COIS- Declarations. Competing Interests: The authors declare no competing interests. Ethical Approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by The University of British Columbia (H20-00848). Consent to Participate: Written informed consent and assent were obtained from parents/guardians and participants, respectively. EDAT- 2026/10/11 05:38 MHDA- 2026/10/11 05:38 CRDT- 2026/10/10 23:34 PHST- 2026/05/29 00:00 [received] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/11 05:38 [medline] PHST- 2026/10/11 05:38 [pubmed] PHST- 2026/10/10 23:34 [entrez] AID - 10.1007/s00246-026-04469-9 [pii] AID - 10.1007/s00246-026-04469-9 [doi] PST - aheadofprint SO - Pediatr Cardiol. 2026 Oct 10. doi: 10.1007/s00246-026-04469-9. PMID- 42858697 OWN - NLM STAT- MEDLINE DCOM- 20261028 LR - 20261028 IS - 1532-1983 (Electronic) IS - 0261-5614 (Linking) VI - 66 DP - 2026 Nov TI - Dietary patterns and adverse pregnancy outcomes: Complementary insights from a priori and a posteriori approaches in a prospective cohort. PG - 106812 LID - S0261-5614(26)00239-6 [pii] LID - 10.1016/j.clnu.2026.106812 [doi] AB - BACKGROUND & AIMS: Maternal diet during pregnancy may influence fetal growth, but evidence based on dietary-pattern approaches remains scarce. We characterized prenatal dietary patterns in a pregnancy cohort using two a priori diet-quality indices and an unsupervised a posteriori data-driven approach, and evaluated their associations with gestational and neonatal outcomes, and assessed the overlap between both methodological approaches. METHODS: We analyzed 595 mother-infant dyads from the Nutrition in Early Life and Asthma (NELA) birth cohort. Maternal diet at 19-22 weeks' gestation was assessed using a validated 123-item food frequency questionnaire. Adherence to the Mediterranean diet and to the Planetary Health diet was quantified using the relative Mediterranean Diet score (rMED) and the Planetary Health Diet Index (PHDI). In addition, we used principal components analysis (PCA) on energy-adjusted food groups, and then hierarchical clustering on the retained scores to identify real-world dietary patterns. Multivariable linear regression analysis was used to explore the association between dietary patterns and gestational weight gain (GWG), neonatal birth weight, and head circumference. A multinomial logistic regression model assessed the capacity of a priori indices to predict cluster membership, evaluated through McFadden's pseudo-R(2), overall accuracy, and Cohen's kappa. RESULTS: Five dietary clusters were identified, with the following proportion of the population in each cluster: Cluster I (9.7%), Cluster II (31.1%), Cluster III (46.7%), Cluster IV (11.4%), and Cluster V (1.0%). Cluster II showed the highest adherence to both indices (mean rMED 9.4; mean PHDI 85.6). Cluster IV (second highest adherence) was consistently associated with lower GWG and higher birth weight compared with Cluster II in adjusted models (-1.28 kg; 95% CI -2.55 to -0.02 and 134.4 g; 95% CI 30.42 to 238.4, respectively) but not head circumference. No associations were found for the rest of clusters or rMED and PHDI indexes. The comparison between approaches revealed poor classification accuracy (55.5%), and slight-to-fair agreement (Cohen's kappa = 0.24). CONCLUSION: An empirically derived dietary profile characterized by vegetables, tubers, legumes, and dairy intake, was associated with lower GWG and higher birth weight. The limited agreement between approaches highlights that a priori indices and data-driven methods capture complementary dimensions of diet, supporting their combined use. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Notario Barandiaran, Leyre AU - Notario Barandiaran L AD - Department of Epidemiology, Geisel School of Medicine, Dartmouth College, NH, USA. Electronic address: Leyre.Notario.Barandiaran@dartmouth.edu. FAU - Diaz Coto, Susana AU - Diaz Coto S AD - Department of Orthopaedics, Dartmouth Health. Geisel School of Medicine at Dartmouth, NH, USA. FAU - Martinez Camblor, Pablo AU - Martinez Camblor P AD - Department of Anesthesiology, Dartmouth Health. Geisel School of Medicine at Dartmouth, NH, USA; Faculty of Health Sciences, Universidad Autonoma de Chile, Chile. FAU - Martinez-Gracia, Carmen AU - Martinez-Gracia C AD - Department of Food Science and Technology, Faculty of Veterinary, University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain. FAU - Suarez-Martinez, Clara AU - Suarez-Martinez C AD - Department of Food Science and Technology, Faculty of Veterinary, University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain. FAU - Santaella-Pascual, Marina AU - Santaella-Pascual M AD - Department of Food Science and Technology, Faculty of Veterinary, University of Murcia, Murcia, Spain; Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain. FAU - Prieto-Sanchez, M Teresa AU - Prieto-Sanchez MT AD - Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain; Obstetrics and Gynecology Service, Virgen de la Arrixaca University Clinical Hospital, University of Murcia, Murcia, Spain. FAU - Sanchez-Ferrer, Maria Luisa AU - Sanchez-Ferrer ML AD - Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain; Obstetrics and Gynecology Service, Virgen de la Arrixaca University Clinical Hospital, University of Murcia, Murcia, Spain. FAU - Morales, Eva AU - Morales E AD - Biomedical Research Institute of Murcia (IMIB-Arrixaca), Murcia, Spain; Division of Preventive Medicine and Public Health, Department of Public Health Sciences, Faculty of Medicine, University of Murcia, Murcia, Spain; CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. FAU - Karagas, Margaret R AU - Karagas MR AD - Department of Epidemiology, Geisel School of Medicine, Dartmouth College, NH, USA. FAU - Signes-Pastor, Antonio J AU - Signes-Pastor AJ AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Unidad de Epidemiologia de la Nutricion. Universidad Miguel Hernandez, Alicante, Spain; Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Spain. Electronic address: asignes@umh.es. CN - of the NELA Study Group LA - eng PT - Journal Article DEP - 20261005 PL - England TA - Clin Nutr JT - Clinical nutrition (Edinburgh, Scotland) JID - 8309603 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Prospective Studies MH - *Pregnancy Outcome/epidemiology MH - Adult MH - Diet, Mediterranean/statistics & numerical data MH - Infant, Newborn MH - *Maternal Nutritional Physiological Phenomena MH - *Diet/statistics & numerical data/methods/adverse effects MH - Birth Weight MH - Gestational Weight Gain OTO - NOTNLM OT - Birth outcomes OT - Dietary assessment methods OT - Dietary patterns OT - Gestational weight gain OT - Mediterranean diet OT - Planetary health diet COIS- Conflict of interest The authors declare no conflict of interest. EDAT- 2026/10/11 04:08 MHDA- 2026/10/28 23:26 CRDT- 2026/10/10 19:25 PHST- 2026/03/25 00:00 [received] PHST- 2026/09/21 00:00 [revised] PHST- 2026/09/27 00:00 [accepted] PHST- 2026/10/28 23:26 [medline] PHST- 2026/10/11 04:08 [pubmed] PHST- 2026/10/10 19:25 [entrez] AID - S0261-5614(26)00239-6 [pii] AID - 10.1016/j.clnu.2026.106812 [doi] PST - ppublish SO - Clin Nutr. 2026 Nov;66:106812. doi: 10.1016/j.clnu.2026.106812. Epub 2026 Oct 5. PMID- 42858478 OWN - NLM STAT- Publisher LR - 20261010 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 153 DP - 2026 Sep 17 TI - Lean soft tissue and appendicular lean soft tissue in adolescent soccer players: new predictive equations using raw multifrequency impedance analysis data. PG - 113435 LID - S0899-9007(26)00342-4 [pii] LID - 10.1016/j.nut.2026.113435 [doi] AB - BACKGROUND: As determinants of soccer player performance, lean soft tissue (LST) and appendicular lean soft tissue (ALST) require accurate, segment-specific assessment. OBJECTIVE: This study aimed to develop LST and ALST predictive equations from multi-frequency bioelectrical impedance analysis data at 50 and 500 kHz using raw data from an octapolar device and evaluate their predictive performance using dual-energy X-ray absorptiometry as a reference method via split-sample validation. METHODS: Multiple linear regression models were developed using body mass, impedance index, and maturity offset as predictors. Model performance was evaluated using adjusted R(2), standard error of estimate (SEE), root mean square error, mean absolute error, Lin's concordance correlation coefficient (CCC), and Bland-Altman agreement analysis. Participants were randomly allocated into a development (n = 100) and an independent validation subset (n = 49). RESULTS: Predictive performance was comparable between frequencies, with high explanatory power (R(2) for LST = 0.953-0.955; ALST = 0.931-0.932) and low prediction error (SEE  .90). Structural equation modeling with bootstrapped mediation analysis was used to examine the direct and indirect associations between the cognitive dimension and children's physical activity. RESULTS: Declarative knowledge showed a small but significant direct association with the number of active days (beta = .10), with a complementary mediation via motor abilities (beta = .12). Procedural knowledge followed an 'indirect-only pattern' on number of sports and exercises performed via the affective dimension (beta = .09). CONCLUSION: Knowledge showed limited direct associations with physical activity but indirect pathways via physical and affective dimensions, highlighting the potential of embedding cognitive content in active learning experiences. Promoting physical literacy in physical activity settings should address all its dimensions and embed knowledge acquisition within physical activity. CI - (c) 2026 The Society of Chinese Scholars on Exercise Physiology and Fitness. Published by Elsevier B.V. FAU - Schuck, Tizian AU - Schuck T AD - Bayreuth Center of Sport Science, Chair of Social and Health Sciences, University of Bayreuth, Universitatsstrasse 30, Bayreuth, 95447, Germany. AD - Department of Sport Science and Sport, Chair of Education in Sport, Friedrich-Alexander-University of Erlangen-Nurnberg, Gebbertstrasse 123b, Erlangen, 91058, Germany. FAU - Carl, Johannes AU - Carl J AD - Department of Sport and Human Movement Sciences , University of Vienna, Auf der Schmelz 6a, Wien, 1150, Austria. FAU - Tittlbach, Susanne AU - Tittlbach S AD - Bayreuth Center of Sport Science, Chair of Social and Health Sciences, University of Bayreuth, Universitatsstrasse 30, Bayreuth, 95447, Germany. LA - eng PT - Journal Article DEP - 20260923 PL - Singapore TA - J Exerc Sci Fit JT - Journal of exercise science and fitness JID - 101198241 PMC - PMC13651661 OTO - NOTNLM OT - Cognitive dimension OT - Daily behavior OT - Health-related knowledge OT - Mediation analysis COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/11 05:07 MHDA- 2026/10/11 05:08 PMCR- 2026/09/23 CRDT- 2026/10/10 14:30 PHST- 2026/06/07 00:00 [received] PHST- 2026/07/31 00:00 [revised] PHST- 2026/09/14 00:00 [accepted] PHST- 2026/10/11 05:08 [medline] PHST- 2026/10/11 05:07 [pubmed] PHST- 2026/10/10 14:30 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - S1728-869X(26)00085-7 [pii] AID - 200524 [pii] AID - 10.1016/j.jesf.2026.200524 [doi] PST - ppublish SO - J Exerc Sci Fit. 2026 Oct;24(4):200524. doi: 10.1016/j.jesf.2026.200524. Epub 2026 Sep 23. PMID- 42857025 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261010 LR - 20261012 IS - 2296-634X (Print) IS - 2296-634X (Electronic) IS - 2296-634X (Linking) VI - 14 DP - 2026 TI - MAFLD and impaired bone formation in children: association with reduced serum LCAT. PG - 1902360 LID - 10.3389/fcell.2026.1902360 [doi] LID - 1902360 AB - PURPOSE: To evaluate bone metabolism indicators and serum lecithin-cholesterol acyltransferase (LCAT) levels in children with metabolic dysfunction-associated fatty liver disease (MAFLD), and to explore their interrelationship. PATIENTS AND METHODS: This study enrolled 127 children aged 6-14 years, classified into control (n = 42), obesity without hepatic steatosis (n = 41), and MAFLD (n = 44) groups. All participants underwent clinical evaluation, laboratory testing, and liver ultrasonography. Serum LCAT was quantified by enzyme-linked immunosorbent assay (ELISA). Bone turnover markers, including procollagen type I N-terminal propeptide (PINP), beta-C-terminal telopeptide of type I collagen (beta-CTX), and 25-hydroxyvitamin D [25-(OH) D], were measured via electrochemiluminescence. Independent risk factors for impaired bone formation were analyzed using multivariable ordinal logistic regression. RESULTS: Serum LCAT concentrations were highest in controls (58.27 +/- 4.43 mg/L), followed by obesity without hepatic steatosis (46.13 +/- 3.37 mg/L), and lowest in the MAFLD group (40.71 +/- 3.44 mg/L) (P < 0.001). The proportion of children with PINP below the 25th percentile was significantly greater in the MAFLD group (88.64%) than in obesity (48.78%) and control groups (35.71%) (P < 0.001). Significant intergroup differences were observed for 25-(OH) D, PINP values, PINP grade, and PINP/beta-CTX ratio; PINP grade distribution differed among groups (P < 0.001), whereas beta-CTX grade did not. Spearman analysis revealed significant correlations of LCAT with HDL-C, AST, ALT, fatty liver status, 25-(OH) D, and PINP grade (all P < 0.001). Multivariable ordinal logistic regression identified MAFLD (OR = 4.74, 95% CI: 1.41-15.99, P = 0.012) and older age (OR = 1.38, 95% CI: 1.08-1.75, P = 0.009) as independent factors associated with lower PINP grade, whereas LCAT was not independently associated with PINP grade. CONCLUSION: MAFLD was independently associated with lower PINP status in children. Reduced serum LCAT levels were associated with MAFLD and unfavorable bone formation status but were not independently associated with PINP grade after multivariable adjustment. LCAT may therefore represent an associated biomarker within the liver-bone axis, requiring validation through prospective studies, formal mediation analyses, and mechanistic experiments. CI - Copyright (c) 2026 Zhu, Xu, Yang, Sun and Yang. FAU - Zhu, Lingyan AU - Zhu L AD - Department of Pediatrics, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China. AD - Department of Pediatrics, Yingfeng Branch, General Hospital of the Medical Consortium of Zhejiang Xiaoshan Hospital, Hangzhou, Zhejiang, China. FAU - Xu, Lin AU - Xu L AD - Department of Pediatrics, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China. FAU - Yang, Lanshu AU - Yang L AD - Department of Pediatrics, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China. AD - Department of Pediatrics, Chongzhou Maternal and Child Healthcare Hospital, Chengdu, Sichuan, China. FAU - Sun, Baolan AU - Sun B AD - Department of Laboratory, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China. FAU - Yang, Weixia AU - Yang W AD - Department of Pediatrics, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260925 PL - Switzerland TA - Front Cell Dev Biol JT - Frontiers in cell and developmental biology JID - 101630250 PMC - PMC13649763 OTO - NOTNLM OT - LCAT OT - MAFLD OT - bone metabolism OT - liver-bone axis OT - obesity OT - pediatrics COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/11 05:07 MHDA- 2026/10/11 05:08 PMCR- 2026/09/25 CRDT- 2026/10/10 13:26 PHST- 2026/06/07 00:00 [received] PHST- 2026/09/02 00:00 [revised] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/10/11 05:08 [medline] PHST- 2026/10/11 05:07 [pubmed] PHST- 2026/10/10 13:26 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - 1902360 [pii] AID - 10.3389/fcell.2026.1902360 [doi] PST - epublish SO - Front Cell Dev Biol. 2026 Sep 25;14:1902360. doi: 10.3389/fcell.2026.1902360. eCollection 2026. PMID- 42856855 OWN - NLM STAT- MEDLINE DCOM- 20261010 LR - 20261012 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Rare endocannabinoid system variants identified by whole-exome sequencing and structural modeling in adults with severe obesity predominantly of childhood onset. PG - 1862926 LID - 10.3389/fendo.2026.1862926 [doi] LID - 1862926 AB - BACKGROUND: The endocannabinoid system (ECS) regulates key processes in energy homeostasis, but its contribution to severe obesity beginning in childhood or adolescence remains incompletely understood. This study aimed to identify rare variants in ECS genes and evaluate their potential structural effects. METHODS: A total of 93 adults with severe obesity beginning before 21 years of age (BMI >/= 35 kg/m(2)) were recruited from two specialized obesity programs; among participants with onset information, 97.8% reported childhood onset. Whole-exome sequencing was performed, followed by targeted analysis of ECS-related genes. Rare variants (allele frequency <1%) were confirmed by Sanger sequencing and assessed using in silico pathogenicity prediction and molecular modeling. In silico saturation mutagenesis of all 19 possible substitutions at each variant position was additionally performed using three complementary stability predictors based on different methodological principles (FoldX, Pythia and DDMut), together with AlphaMissense. RESULTS: Nine rare variants were identified in twelve individuals, seven of which were defined as variants of uncertain significance (VUS). Among the observed variants, FAAH p.(Arg326Pro) showed the most concordant predicted impact: it ranked as the most destabilizing substitution at position 326 by FoldX (DeltaDeltaG = +3.04 kcal/mol; rank 1 of 19) and was the only observed variant classified as likely pathogenic by AlphaMissense (0.884). Arg326 lies 24.3 A from the catalytic triad (Lys142-Ser217-Ser241), consistent with a predicted effect on fold stability rather than direct disruption of the active site. Conversely, at DAGLA position 750, all 19 substitutions were predicted as neutral by FoldX and DDMut and as likely benign by AlphaMissense, consistent with predicted structural tolerance at this position. No anthropometric or metabolic parameter differed significantly between carriers and non-carriers after correction for multiple testing. CONCLUSIONS: Rare ECS variants, including a previously unreported FAAH p.(Arg326Pro) substitution, were identified in adults with severe obesity, predominantly with childhood onset. These in silico analyses are predictive and provide computational evidence for prioritizing candidate variants, notably FAAH p.(Arg326Pro); they do not, by themselves, establish pathogenicity or a causal relationship with the phenotype, which will require functional validation. CI - Copyright (c) 2026 Salum, Souza, Antunes, Assis, Gouvea, Teixeira, Melo, Palhinha, Abreu, Alves, Silva, Zembrzuski, Campos Junior, Maya-Monteiro, Bozza, da Fonseca and Carneiro. FAU - Salum, Kaio Cezar Rodrigues AU - Salum KCR AD - Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. AD - Molecular Genetics Laboratory, Paulo Niemeyer State Institute of the Brain, Rio de Janeiro, Brazil. FAU - de Souza, Ritiele Bastos AU - de Souza RB AD - Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. AD - Laboratory for Applied Genomics and Bioinnovations, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Antunes, Deborah AU - Antunes D AD - Laboratory for Applied Genomics and Bioinnovations, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Assis, Izadora Sthephanie da Silva AU - Assis ISDS AD - Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. AD - Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Gouvea, Laura Wendling AU - Gouvea LW AD - Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Teixeira, Myrela Ribeiro AU - Teixeira MR AD - Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. AD - Human Genetics Laboratory, Institute of Biology, Federal Fluminense University, Niteroi, Rio de Janeiro, Brazil. FAU - de Melo, Marilia Alves Figueira AU - de Melo MAF AD - Cellular Microbiology Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Palhinha, Lohanna AU - Palhinha L AD - Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Abreu, Gabriella de Medeiros AU - Abreu GM AD - Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. AD - Genetics Laboratory, Grande Rio University/AFYA, Rio de Janeiro, Brazil. FAU - Alves, Nathalia da Silva AU - Alves NDS AD - Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. AD - Genetics Laboratory, Grande Rio University/AFYA, Rio de Janeiro, Brazil. FAU - Silva, Tamara AU - Silva T AD - Genetics Laboratory, Grande Rio University/AFYA, Rio de Janeiro, Brazil. FAU - Zembrzuski, Veronica Marques AU - Zembrzuski VM AD - Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Campos Junior, Mario AU - Campos Junior M AD - Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Maya-Monteiro, Clarissa Menezes AU - Maya-Monteiro CM AD - Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - Bozza, Patricia Torres AU - Bozza PT AD - Laboratory of Immunopharmacology, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. FAU - da Fonseca, Ana Carolina Proenca AU - da Fonseca ACP AD - Human Genetics Laboratory, Oswaldo Cruz Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. AD - Genetics Laboratory, Grande Rio University/AFYA, Rio de Janeiro, Brazil. FAU - Carneiro, Joao Regis Ivar AU - Carneiro JRI AD - Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. LA - eng PT - Journal Article DEP - 20260925 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Endocannabinoids) RN - EC 3.5.1.- (Fatty Acid Amide Hydrolases) RN - EC 3.5.- (Amidohydrolases) SB - IM MH - Humans MH - *Endocannabinoids/genetics/metabolism MH - Female MH - Exome Sequencing MH - *Obesity, Morbid/genetics/metabolism MH - Adult MH - Fatty Acid Amide Hydrolases MH - Male MH - Age of Onset MH - Models, Molecular MH - *Amidohydrolases/genetics/chemistry MH - Young Adult MH - Adolescent MH - Child MH - Mutation MH - Genetic Variation PMC - PMC13649445 OTO - NOTNLM OT - FAAH OT - childhood-onset obesity OT - endocannabinoid system OT - molecular modeling OT - rare genetic variants COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/10/11 05:07 MHDA- 2026/10/11 05:08 PMCR- 2026/09/25 CRDT- 2026/10/10 12:03 PHST- 2026/04/22 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/11 05:08 [medline] PHST- 2026/10/11 05:07 [pubmed] PHST- 2026/10/10 12:03 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - 10.3389/fendo.2026.1862926 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 25;17:1862926. doi: 10.3389/fendo.2026.1862926. eCollection 2026. PMID- 42856768 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261010 LR - 20261012 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Low baseline alanine aminotransferase is associated with primary non-response to infliximab induction in pediatric Crohn's disease: a retrospective cohort study. PG - 1948999 LID - 10.3389/fped.2026.1948999 [doi] LID - 1948999 AB - BACKGROUND: Low alanine aminotransferase (ALT) has been associated with unfavorable inflammatory and nutritional phenotypes, but its relationship with infliximab (IFX) response in pediatric Crohn's disease (CD) is uncertain. METHODS: We retrospectively studied 116 children with CD who received IFX induction at weeks 0, 2, and 6 and underwent response assessment at approximately week 14. Low ALT was defined as <10 U/L using a rounded, data-informed working threshold. Primary non-response (PNR) required concurrent clinical non-response, biochemical activity, and objective endoscopic or cross-sectional imaging evidence and was independently adjudicated by two pediatric gastroenterologists blinded to baseline ALT. Firth logistic regression assessed the association between low ALT and PNR after adjustment for baseline SES-CD, IFX dose, and concomitant immunomodulator use. RESULTS: Fifty-eight children (50.0%) had low ALT and 21 (18.1%) had PNR. PNR occurred more often with low ALT (27.6% vs. 8.6%; P = 0.008). Low ALT remained associated with PNR after adjustment (OR, 4.03; 95% CI, 1.48-12.65; P = 0.006), and each 5-U/L decrease in ALT was associated with higher odds of PNR (OR, 1.50; 95% CI, 1.04-2.59; P = 0.022). Discrimination was limited (AUC, 0.677; bootstrap 95% CI, 0.547-0.802). CONCLUSION: Low baseline ALT was associated with PNR to IFX in pediatric CD. This exploratory association and the 10-U/L working threshold require external validation and should not guide treatment decisions in isolation. CI - (c) 2026 Wang, Guo and Wu. FAU - Wang, Yuhang AU - Wang Y AD - Gastroenterology, Hepatology and Nutrition Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Guo, Cheng AU - Guo C AD - Gastroenterology, Hepatology and Nutrition Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Wu, Jie AU - Wu J AD - Gastroenterology, Hepatology and Nutrition Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. LA - eng PT - Journal Article DEP - 20260925 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13649988 OTO - NOTNLM OT - alanine aminotransferase OT - biologic therapy OT - inflammatory bowel disease OT - infliximab OT - pediatric Crohn's disease OT - primary non-response COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/11 05:07 MHDA- 2026/10/11 05:08 PMCR- 2026/09/25 CRDT- 2026/10/10 11:09 PHST- 2026/07/26 00:00 [received] PHST- 2026/09/04 00:00 [revised] PHST- 2026/09/08 00:00 [accepted] PHST- 2026/10/11 05:08 [medline] PHST- 2026/10/11 05:07 [pubmed] PHST- 2026/10/10 11:09 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - 10.3389/fped.2026.1948999 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 25;14:1948999. doi: 10.3389/fped.2026.1948999. eCollection 2026. PMID- 42855966 OWN - NLM STAT- MEDLINE DCOM- 20261010 LR - 20261014 IS - 1365-2060 (Electronic) IS - 0785-3890 (Print) IS - 0785-3890 (Linking) VI - 58 IP - 1 DP - 2026 Dec TI - How much of the incremental protocol does a lactate threshold need? Agreement between three-stage and five-stage testing across seven lactate-derived indices in swimmers. PG - 2737006 LID - 10.1080/07853890.2026.2737006 [doi] LID - 2737006 AB - BACKGROUND: Incremental lactate testing is widely used to characterize the lactate-velocity relationship in swimmers, but the highest-intensity stages increase testing burden and may be difficult to execute consistently. OBJECTIVE: To determine whether a five-stage protocol can be reduced to three stages without materially changing seven lactate-derived velocity indices, and whether model complexity affects reconstruction. METHODS: Ninety highly trained swimmers completed a 5 x 200 m freestyle incremental test at 80-100% of 200 m personal-best performance. Stage-4 and stage-5 lactate values were reconstructed from the first three stages using participant-specific linear extrapolation and a long short-term memory (LSTM) model. Seven lactate-derived indices were recalculated and compared with full-protocol values using limits of agreement, typical error, ICC(A,1) and equivalence testing. RESULTS: Lactate reconstruction was inaccurate for both models, yet v@Exp-Dmax showed close agreement with the full protocol (bias -0.008 m.s(-1); limits of agreement -0.023 to +0.007 m.s(-1); ICC 0.988) and met the pre-specified equivalence criterion. The other six indices did not meet equivalence. LSTM provided no advantage over linear extrapolation, and reconstructed v@Exp-Dmax preserved the performance-association pattern observed with the full protocol. CONCLUSIONS: A three-stage protocol may support lower-burden longitudinal monitoring of v@Exp-Dmax, but protocol simplification is index-specific and does not establish physiological threshold validity. FAU - Shen, Yupeng AU - Shen Y AUID- ORCID: 0000-0002-2960-2510 AD - School of physical education and sports science, South China Normal University, Guangzhou, China. FAU - Zou, Xinnuo AU - Zou X AD - School of physical education and sports science, South China Normal University, Guangzhou, China. FAU - Chen, Xiaotong AU - Chen X AUID- ORCID: 0000-0002-9260-9395 AD - School of physical education and sports science, South China Normal University, Guangzhou, China. AD - Sports Academy, Guangzhou College of Commerce, Guangzhou, China. FAU - Wu, Xiaobin AU - Wu X AD - School of Physical Education, Chengdu Sport University, Chengdu, China. LA - eng PT - Journal Article DEP - 20261009 PL - England TA - Ann Med JT - Annals of medicine JID - 8906388 RN - 33X04XA5AT (Lactic Acid) SB - IM MH - Humans MH - *Swimming/physiology MH - *Lactic Acid/blood MH - Male MH - *Exercise Test/methods MH - Female MH - Adolescent MH - *Anaerobic Threshold/physiology MH - *Athletic Performance/physiology MH - Reproducibility of Results PMC - PMC13656679 OTO - NOTNLM OT - Exp-Dmax OT - Lactate threshold OT - incremental testing OT - swimming COIS- No potential conflict of interest was reported by the author(s). EDAT- 2026/10/10 05:32 MHDA- 2026/10/10 05:33 PMCR- 2026/10/09 CRDT- 2026/10/10 02:52 PHST- 2026/10/10 05:33 [medline] PHST- 2026/10/10 05:32 [pubmed] PHST- 2026/10/10 02:52 [entrez] PHST- 2026/10/09 00:00 [pmc-release] AID - 2737006 [pii] AID - 10.1080/07853890.2026.2737006 [doi] PST - ppublish SO - Ann Med. 2026 Dec;58(1):2737006. doi: 10.1080/07853890.2026.2737006. Epub 2026 Oct 9. PMID- 42855587 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261013 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 11 DP - 2026 Oct 9 TI - Obstructive sleep apnoea severity and insulin resistance in children with Prader-Willi Syndrome: the SPISE index as a candidate metabolic marker. LID - 826 [pii] LID - 10.1007/s00431-026-07506-0 [doi] AB - We compared two surrogate markers of insulin sensitivity - the single-point insulin sensitivity estimator (SPISE) and HOMA-IR - and evaluated their associations with OSA severity in children with genetically confirmed PWS and a symptomatic non-syndromic referral group (NSR) with available polysomnography (PSG) and fasting biochemical data. In this single-centre retrospective cross-sectional study, OSA severity was indexed by the obstructive apnoea-hypopnoea index (oAHI), central AHI (cAHI) and oxygen desaturation index (ODI), and caregiver-reported symptoms by the PSQ-SRBD scale. Multivariable models were fitted within the PWS group. Of 458 PSG studies screened, 31 children with PWS and 47 NSR met the inclusion criteria. cAHI was higher in PWS (p < 0.001), and PSQ-SRBD scores were slightly lower, despite a similar oAHI distribution. Within the PWS group, oAHI correlated inversely with SPISE (rho = - 0.378, p = 0.036). In multivariable models adjusted for age, sex, BMI-SDS, and growth hormone therapy, higher oAHI was associated with lower SPISE (B = - 0.154, p = 0.015), whereas the association with ln(HOMA-IR) was borderline (B = 0.081, p = 0.0497). ODI correlated with SPISE (rho = - 0.427, p = 0.017) but not with HOMA-IR (rho = 0.319, p = 0.081). Phase-stratified analyses showed oAHI-SPISE correlations in phases 2 and 3 and an oAHI-HOMA-IR correlation in phase 3. CONCLUSION: In children with PWS, OSA severity was associated with markers of impaired insulin sensitivity. The associations of SPISE with oAHI and ODI support its further investigation as a candidate metabolic correlate of OSA severity. These findings are hypothesis-generating and require validation in larger independent cohorts. WHAT IS KNOWN: * OSA is highly prevalent in PWS. OSA severity is associated with insulin resistance in adults and in non-syndromic children with obesity, but this relationship and the insulin-independent SPISE index have not been evaluated in PWS. WHAT IS NEW: * OSA severity was associated with impaired insulin sensitivity markers in children with PWS. * SPISE, derived from lipids and BMI without fasting insulin, was associated with oAHI and ODI in PWS; it merits further investigation as a candidate metabolic correlate of OSA severity. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Guney, Abdurrahman Zarif AU - Guney AZ AUID- ORCID: 0000-0002-6956-8820 AD - Division of Paediatric Pulmonology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Akpinar, Osman Talha AU - Akpinar OT AUID- ORCID: 0009-0001-6671-7237 AD - Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Gokden, Meltem AU - Gokden M AUID- ORCID: 0000-0002-8284-0788 AD - Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Yilmaz, Furkan AU - Yilmaz F AUID- ORCID: 0000-0001-6459-9647 AD - Division of Paediatric Pulmonology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Korkmaz, Cigdem AU - Korkmaz C AUID- ORCID: 0000-0002-2096-2253 AD - Division of Paediatric Pulmonology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Oztosun, Berrak Nevin AU - Oztosun BN AUID- ORCID: 0000-0001-5649-8045 AD - Division of Paediatric Pulmonology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Collak, Abdulhamit AU - Collak A AUID- ORCID: 0000-0002-0562-0343 AD - Division of Paediatric Pulmonology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Turan, Hande AU - Turan H AUID- ORCID: 0000-0003-0121-3756 AD - Division of Paediatric Endocrinology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Bayramoglu, Elvan AU - Bayramoglu E AUID- ORCID: 0000-0002-6732-8823 AD - Division of Paediatric Endocrinology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Evliyaoglu, Olcay AU - Evliyaoglu O AUID- ORCID: 0000-0003-4851-8637 AD - Division of Paediatric Endocrinology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. FAU - Kilinc Sakalli, Ayse Ayzit AU - Kilinc Sakalli AA AUID- ORCID: 0000-0002-2879-8910 AD - Division of Paediatric Pulmonology, Department of Paediatrics, Cerrahpasa Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey. kilincayse203@gmail.com. LA - eng PT - Journal Article DEP - 20261009 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Insulin Resistance MH - *Prader-Willi Syndrome/complications/metabolism MH - *Sleep Apnea, Obstructive/diagnosis/etiology MH - Female MH - Cross-Sectional Studies MH - Male MH - Retrospective Studies MH - Polysomnography MH - Severity of Illness Index MH - Biomarkers/blood MH - Child MH - Child, Preschool MH - Adolescent OTO - NOTNLM OT - HOMA-IR OT - Insulin resistance OT - Obstructive sleep apnoea OT - Paediatrics OT - Prader-Willi syndrome OT - SPISE COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. This retrospective study was approved by the Istanbul University-Cerrahpasa Clinical Research Ethics Committee (approval date: 24 December 2025; approval no. E-24687260-604.01-1513367). Consent to participate: This was a retrospective study based on de-identified data extracted from existing medical records collected as part of routine clinical care. Formal informed consent was therefore not sought for the retrospective analysis. Consent to publish: Not applicable. The manuscript contains no individual person's identifying data, images, or videos. Competing interests: The authors declare no competing interests. EDAT- 2026/10/10 05:32 MHDA- 2026/10/10 05:33 CRDT- 2026/10/09 23:37 PHST- 2026/06/13 00:00 [received] PHST- 2026/10/05 00:00 [accepted] PHST- 2026/09/26 00:00 [revised] PHST- 2026/10/10 05:33 [medline] PHST- 2026/10/10 05:32 [pubmed] PHST- 2026/10/09 23:37 [entrez] AID - 10.1007/s00431-026-07506-0 [pii] AID - 10.1007/s00431-026-07506-0 [doi] PST - epublish SO - Eur J Pediatr. 2026 Oct 9;185(11):826. doi: 10.1007/s00431-026-07506-0. PMID- 42855145 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261026 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Oct 9 TI - Feasibility, Acceptability, and Appropriateness of an 8-Week Supervised Aerobic Exercise Intervention for Adults With Epilepsy: Pilot Randomized Controlled Trial. PG - e97392 LID - 10.2196/97392 [doi] LID - e97392 AB - BACKGROUND: Epilepsy affects multiple dimensions of health. Exercise may serve as a nonpharmacological strategy to improve health outcomes among adults with epilepsy; however, translating this potential into effective and scalable interventions remains challenging. Before advancing to efficacy trials, early-stage research is needed to establish whether exercise interventions are feasible, acceptable, and appropriate for this population. OBJECTIVE: This study aimed to evaluate the feasibility, acceptability, and appropriateness of an 8-week supervised aerobic exercise intervention for adults with epilepsy, guided by the Obesity-Related Behavioral Intervention Trials (ORBIT) model. METHODS: Adults with epilepsy aged 18-65 years were recruited between April 2024 and December 2024 and randomized to either a supervised aerobic exercise intervention (n=4) or a control group (n=2). The exercise group completed an 8-week supervised aerobic exercise program consisting of 50-minute sessions performed 3 days per week. The intervention incorporated behavior change techniques, including goal setting, action planning, habit formation, and commitment contracts to support exercise adherence. Process feasibility outcomes included recruitment, retention, adherence, survey completion, protocol compliance, and safety. Self-reported feasibility, acceptability, and appropriateness were assessed using the Feasibility of Intervention Measure, Acceptability of Intervention Measure, and Intervention Appropriateness Measure. RESULTS: Overall, 34 individuals expressed interest in the study, 25 completed the screening survey, 10 were preliminarily eligible, and 6 were enrolled in the study over 8 months. Recruitment was low, with a recruitment rate of 0.75 participants per month and enrollment achievement of 16.7% of the target sample (target n=36). Retention and adherence were 100%. All exercise participants completed 24/24 sessions, with 100% weekly survey completion. Protocol compliance was high. No seizures occurred during exercise sessions. Mean scores for self-reported feasibility, acceptability, and appropriateness were high (>4 out of 5). CONCLUSIONS: The results of this Phase IIb pilot study suggest that a supervised aerobic exercise intervention for adults with epilepsy is feasible, acceptable, and appropriate to implement among participants who enroll. Recruitment remains the primary challenge to progressing this line of research and may represent a broader field-level barrier. Future trials should focus on improving how adults with epilepsy are reached and engaged in exercise research while preserving intervention strategies that support strong engagement among those who enroll. CI - (c)Sydney Churchill, Jeni Lansing, Angelique Brellenthin, Alison Phillips, Elizabeth Stegemoller, Jacob Meyer. Originally published in JMIR Formative Research (https://formative.jmir.org), 09.10.2026. FAU - Churchill, Sydney AU - Churchill S AUID- ORCID: 0000-0002-0271-0749 AD - Department of Exercise and Sport Science, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. FAU - Lansing, Jeni AU - Lansing J AUID- ORCID: 0000-0001-7665-8747 AD - Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, United States. FAU - Brellenthin, Angelique AU - Brellenthin A AUID- ORCID: 0000-0003-2038-389X AD - Department of Kinesiology, Iowa State University, Ames, IA, United States. FAU - Phillips, Alison AU - Phillips A AUID- ORCID: 0000-0003-1126-1559 AD - Department of Psychology, Iowa State University, Ames, IA, United States. FAU - Stegemoller, Elizabeth AU - Stegemoller E AUID- ORCID: 0000-0002-5287-2295 AD - Department of Kinesiology, Iowa State University, Ames, IA, United States. FAU - Meyer, Jacob AU - Meyer J AUID- ORCID: 0000-0003-3180-5728 AD - Department of Kinesiology, University of Wisconsin-Madison, Madison, WI, United States. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20261009 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - *Epilepsy/therapy/psychology MH - Female MH - Adult MH - Middle Aged MH - Pilot Projects MH - Feasibility Studies MH - Male MH - *Exercise Therapy/methods/standards MH - *Exercise/psychology MH - Adolescent MH - *Patient Acceptance of Health Care/statistics & numerical data/psychology MH - Aged MH - Young Adult PMC - PMC13695000 OTO - NOTNLM OT - acceptability OT - aerobic exercise OT - epilepsy OT - feasibility OT - intervention COIS- Conflicts of Interest: None declared. EDAT- 2026/10/09 23:31 MHDA- 2026/10/09 23:32 PMCR- 2026/10/09 CRDT- 2026/10/09 19:53 PHST- 2026/04/06 00:00 [received] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/09/12 00:00 [revised] PHST- 2026/10/09 23:32 [medline] PHST- 2026/10/09 23:31 [pubmed] PHST- 2026/10/09 19:53 [entrez] PHST- 2026/10/09 00:00 [pmc-release] AID - v10i1e97392 [pii] AID - 10.2196/97392 [doi] PST - epublish SO - JMIR Form Res. 2026 Oct 9;10:e97392. doi: 10.2196/97392. PMID- 42853568 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261019 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 9 IP - 10 DP - 2026 Oct 1 TI - A Community-Based Behavioral Intervention and Body Mass Index in School-Aged Children: A Cluster Randomized Clinical Trial. PG - e2638188 LID - 10.1001/jamanetworkopen.2026.38188 [doi] LID - e2638188 AB - IMPORTANCE: Childhood obesity remains a major concern in the US, with increases in body mass index (BMI) observed during and after the COVID-19 pandemic. Scalable behavioral interventions are needed to support obesity prevention in community settings. OBJECTIVE: To evaluate the efficacy of a community-based behavioral intervention (H2GO!) on BMI z scores (zBMIs) among school-aged children. DESIGN, SETTING, AND PARTICIPANTS: This cluster randomized clinical trial was conducted from September 2020 to June 2025 across 11 Boys & Girls Club sites in Massachusetts. Sites were pair-matched and randomized to intervention or usual care condition. Participants included children aged 8 to 13 years and their parents or caregivers. INTERVENTION: Twelve group-based sessions delivered in person over 6 weeks by trained Boys & Girls Club staff using behavioral strategies to reduce sugar-sweetened beverage intake and increase water consumption through health sessions, youth-created narratives, and parent-child activities. Comparison sites received usual programming. MAIN OUTCOMES AND MEASURES: Outcomes were assessed at baseline and at 2, 6, and 12 months using intention-to-treat analyses. The primary outcome was 12-month change from baseline in child zBMI, derived from staff-measured height and weight using standardized protocols. Secondary outcomes included child sugar-sweetened beverage and water intake measured using a validated questionnaire. RESULTS: Among 437 child participants (mean [SD] age, 10.1 [1.2] years; 219 girls [50.1%]), 0.2% were American Indian or Alaska Native, 1.8% were Asian, 15.8% were Black or African American, 42.6% were Hispanic or Latino, and 29.5% were White; 297 (68%) were eligible for free or reduced-price lunch. At baseline, 74 children (16.9%) had overweight, and 161 (36.8%) had obesity. From baseline to 12 months, the mean zBMI did not statistically significantly decrease (-0.11 [95% CI, -0.25 to 0.02]) in the intervention group and did not statistically significantly increase (0.08 [95% CI, -0.04 to 0.20]) in the comparison group; however, the estimated between-group difference in the adjusted mean zBMI change from baseline was statistically significant: -0.19 (95% CI, -0.38 to -0.01; P = .04). Between-group differences in sugar-sweetened beverage and water intake were not significant. CONCLUSIONS AND RELEVANCE: In this cluster randomized clinical trial, a community-based behavioral intervention was associated with a statistically significant between-group difference in zBMI change among school-aged children. Findings support the potential of community-based behavioral interventions in obesity prevention. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04265794. FAU - Wang, Monica L AU - Wang ML AD - Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts. AD - Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. FAU - Alatorre, Selenne AU - Alatorre S AD - Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts. FAU - Schwarz, Aviva G AU - Schwarz AG AD - Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts. AD - Department of Psychiatry, Boston Medical Center, Boston, Massachusetts. FAU - Weinberg, Janice AU - Weinberg J AD - Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts. FAU - Sprague Martinez, Linda AU - Sprague Martinez L AD - Department of Medicine, University of Connecticut School of Social Work, Hartford. FAU - Aldworth, Jennifer AU - Aldworth J AD - Massachusetts Alliance of Boys & Girls Clubs, Ludlow. FAU - Kadel, Rabindra AU - Kadel R AD - Center for Health Data Science, Boston University School of Public Health, Boston, Massachusetts. FAU - Rosal, Milagros C AU - Rosal MC AD - Department of Population and Quantitative Health Sciences, University of Massachusetts T.H. Chan School of Medicine, Worcester. FAU - Lemon, Stephenie C AU - Lemon SC AD - Department of Population and Quantitative Health Sciences, University of Massachusetts T.H. Chan School of Medicine, Worcester. LA - eng SI - ClinicalTrials.gov/NCT04265794 PT - Journal Article PT - Randomized Controlled Trial DEP - 20261001 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Behavior Therapy/methods MH - *Body Mass Index MH - Massachusetts/epidemiology MH - *Pediatric Obesity/prevention & control MH - Sugar-Sweetened Beverages PMC - PMC13653277 COIS- Conflict of Interest Disclosures: Dr Weinberg reported receiving personal fees for being a data monitoring biostatistician from Janssen and Sanofi outside the submitted work. Ms Aldworth reported receiving a National Institutes of Health (NIH)-funded subaward from Boston University, paid to her institution, during the conduct of the study. Dr Rosal reported receiving grants from the NIH during the conduct of the study. No other disclosures were reported. EDAT- 2026/10/09 17:34 MHDA- 2026/10/09 17:35 PMCR- 2026/10/09 CRDT- 2026/10/09 11:34 PHST- 2026/10/09 17:35 [medline] PHST- 2026/10/09 17:34 [pubmed] PHST- 2026/10/09 11:34 [entrez] PHST- 2026/10/09 00:00 [pmc-release] AID - 2855120 [pii] AID - zoi261028 [pii] AID - 10.1001/jamanetworkopen.2026.38188 [doi] PST - epublish SO - JAMA Netw Open. 2026 Oct 1;9(10):e2638188. doi: 10.1001/jamanetworkopen.2026.38188. PMID- 42853511 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261009 IS - 1573-2959 (Electronic) IS - 0167-6369 (Linking) VI - 198 IP - 11 DP - 2026 Oct 9 TI - Environmental occurrence, spatial distribution, and probabilistic dietary risk assessment of cypermethrin and glyphosate residues in agricultural ecosystems of southwestern Nigeria. LID - 1171 [pii] LID - 10.1007/s10661-026-15973-z [doi] AB - Pesticide use in vegetable production raises concerns regarding environmental contamination, food safety, and human health, particularly where pesticide stewardship is inadequate. This study investigated the occurrence, spatial distribution, environmental partitioning, and dietary health risks of cypermethrin and glyphosate in water, sediment, soil, and Amaranthus cruentus collected from 30 sampling sites across three major vegetable-producing settlements in Oyo State, southwestern Nigeria. A total of 240 matrix-season samples were analysed using validated chromatographic methods, generating 480 independent pesticide-specific sample-level observations after analytical duplicates were averaged. Residue data were evaluated using hierarchical mixed-effects modelling, principal component analysis, Moran's I spatial autocorrelation analysis, deterministic dietary risk assessment, empirical Monte Carlo simulation with 10,000 iterations, and a structured survey of vegetable farmers. Glyphosate predominated in soil and sediment, whereas cypermethrin occurred at comparatively higher concentrations in A. cruentus. Significant spatial autocorrelation was detected specifically for glyphosate in sediment (Moran's I = 0.783, p = 0.0003). Deterministic assessment indicated acceptable dietary risk for adults for both pesticides and for glyphosate in children, whereas cypermethrin exceeded the hazard threshold in children (HQ = 1.818). Monte Carlo simulation showed HQ > 1 in 15.09% of adult and 70.47% of child cypermethrin exposure scenarios, while no simulated glyphosate exposure exceeded this threshold. Despite substantial exceedance of selected EU spinach maximum-residue-limit benchmarks, farmer practices indicated limited pesticide stewardship and short pre-harvest intervals. These findings support strengthened pesticide stewardship, residue surveillance, farmer education, and regulatory oversight to improve food safety. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Switzerland AG. FAU - Ojezele, Omolara Jemimah AU - Ojezele OJ AUID- ORCID: 0000-0002-9372-6163 AD - Department of Chemistry/Biochemistry, Federal College of Animal Health and Production Technology, Moor Plantation, Ibadan, Oyo State, Nigeria. omolaraojezele@gmail.com. FAU - Ojezele, Matthew Obaineh AU - Ojezele MO AD - Department of Pharmacology, Delta State University, Abraka, Delta State, Nigeria. LA - eng PT - Journal Article DEP - 20261009 PL - Netherlands TA - Environ Monit Assess JT - Environmental monitoring and assessment JID - 8508350 RN - 1TR49121NP (cypermethrin) RN - 0 (Pyrethrins) RN - TE7660XO1C (Glycine) RN - 4632WW1X5A (Glyphosate) RN - 0 (Pesticide Residues) SB - IM MH - *Pyrethrins/analysis MH - *Glycine/analogs & derivatives/analysis MH - Glyphosate MH - Nigeria MH - Risk Assessment MH - Agriculture MH - *Pesticide Residues/analysis MH - *Environmental Monitoring MH - Ecosystem MH - *Dietary Exposure/statistics & numerical data/analysis MH - Humans MH - Food Contamination/analysis MH - Amaranthus/chemistry MH - Monte Carlo Method OTO - NOTNLM OT - Amaranthus cruentus OT - Environmental partitioning OT - Hierarchical mixed-effects modelling OT - Monte Carlo simulation OT - Moran's I OT - Pesticide stewardship OT - Principal component analysis COIS- Declarations. Ethics approval: Ethical approval for this study was obtained from the Ethics and Research Committee, Department of Pharmacology, Faculty of Basic Medical Sciences, Delta State University, Abraka, Nigeria (Protocol No. RBC/FBMS/DELSU/15/112). The study protocol, including administration of questionnaires to farmers, was reviewed and approved prior to commencement of the research. Consent to participate: Informed consent was obtained from all participants prior to questionnaire administration. Participation was voluntary, and respondents were informed of the purpose of the study and assured of the confidentiality of the information provided. Clinical trial number: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/09 17:34 MHDA- 2026/10/09 17:35 CRDT- 2026/10/09 11:20 PHST- 2026/08/07 00:00 [received] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/09 17:35 [medline] PHST- 2026/10/09 17:34 [pubmed] PHST- 2026/10/09 11:20 [entrez] AID - 10.1007/s10661-026-15973-z [pii] AID - 10.1007/s10661-026-15973-z [doi] PST - epublish SO - Environ Monit Assess. 2026 Oct 9;198(11):1171. doi: 10.1007/s10661-026-15973-z. PMID- 42853195 OWN - NLM STAT- Publisher LR - 20261009 IS - 1532-5040 (Electronic) IS - 0959-3985 (Linking) DP - 2026 Oct 9 TI - From information to action; co-designing pain neuroscience education for adolescents with low back pain: Focus group insights. PG - 1-20 LID - 10.1080/09593985.2026.2743833 [doi] AB - INTRODUCTION: Low back pain (LBP) is a common health problem among adolescents. Adolescents with pain report higher stress, more school absenteeism, poorer academic performance, and frequent healthcare use. LBP during adolescence may increase the risk of pain in adulthood, underscoring the importance of supporting young people in developing strategies to understand and manage pain. OBJECTIVE: To develop educational material based on pain neuroscience education (PNE) through co-design with adolescents experiencing LBP. METHODS: Adolescents 15-19 years old were recruited to review an initial prototype developed by the authors. Four focus group discussions involving 15 participants were conducted and analyzed using Krueger's analysis framework. The findings guided the development of a refined prototype, which was then further improved through an additional focus group with six participants to validate interpretations and adjust content. RESULTS: Four themes captured adolescents' needs in relation to pain education. Need for recognition: "This is about me" emphasized relatable, back-specific information. Need for practical tools and support: "What can I do myself?" reflected adolescents' desire for actionable strategies. A format that sparks interest: "Otherwise I will stop reading" highlighted the importance of engaging, concise content adapted to young people. The pathway from information to useful support: "It must be easy to find" underlined the value of structure and simple navigation. Participants confirmed the relevance of the prototype and suggested adjustments, which guided further refinement. Based on these insights, the final Back To Move prototype was developed as a complement to healthcare services. CONCLUSION: Adolescents with LBP value PNE that is back-specific, practical, trustworthy, and presented in a format adapted to their preferences. When evidence-based knowledge is combined with language and design tailored to the target group, educational material becomes more engaging and supportive. These findings highlight the importance of involving young people as active co-designers of health information. FAU - Ahlqwist, Anna AU - Ahlqwist A AD - Department of Health and Rehabilitation/Physiotherapy, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Danielsson, Louise AU - Danielsson L AD - Department of Health and Rehabilitation/Physiotherapy, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Lundberg, Mari AU - Lundberg M AD - Back in Motion Research Group, Department of Health Promoting Science, Sophiahemmet University, Stockholm, Sweden. AD - Sahlgrenska Academy, University of Gothenburg Centre for Person-Centred Care (GPCC), Gothenburg, Sweden. AD - Pain in Motion Research Group (PAIN), Department of Physiotherapy, Human Physiology and Anatomy, Faculty of Physical Education & Physiotherapy, Vrije Universiteit Brussel, Brussels, Belgium. FAU - Varkey, Emma AU - Varkey E AD - Department of Health and Rehabilitation/Physiotherapy, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Department of Occupational Therapy and Physical Therapy, Sahlgrenska University Hospital/Ostra, Gothenburg, Sweden. LA - eng PT - Journal Article DEP - 20261009 PL - England TA - Physiother Theory Pract JT - Physiotherapy theory and practice JID - 9015520 SB - IM OTO - NOTNLM OT - Low back pain OT - adolescents OT - physical activity OT - physical therapy EDAT- 2026/10/09 11:40 MHDA- 2026/10/09 11:40 CRDT- 2026/10/09 10:34 PHST- 2026/10/09 11:40 [medline] PHST- 2026/10/09 11:40 [pubmed] PHST- 2026/10/09 10:34 [entrez] AID - 10.1080/09593985.2026.2743833 [doi] PST - aheadofprint SO - Physiother Theory Pract. 2026 Oct 9:1-20. doi: 10.1080/09593985.2026.2743833. PMID- 42852973 OWN - NLM STAT- Publisher LR - 20261009 IS - 1545-1569 (Electronic) IS - 1055-6656 (Linking) DP - 2026 Oct 9 TI - Predicting Underweight Status in Infants With Cleft Lip and/or Palate in 10 US Children's Hospitals. PG - 10556656261494318 LID - 10.1177/10556656261494318 [doi] AB - ObjectiveTo develop and compare models predicting which infants with cleft lip and/or palate (CL/P) will be underweight at 4 months, using multicenter electronic health record data.DesignUsing data from birth to 3 months, we evaluated 63 anthropometric, clinical, healthcare-utilization, and demographic variables across 6 regression and machine-learning models to identify the strongest predictors of underweight status, overall and by cleft type.SettingTen US children's hospitals in PEDSnet, a national pediatric learning health network, 2009 to 2024.PatientsInfants with CL/P aged 0 to 4.5 months.Main Outcome MeasureUnderweight status at 4 months (range 3.5-4.5), defined as weight-for-age z-score (WAZ) < -2.ResultsAmong 5717 infants with CL/P (19% cleft lip, 35% cleft lip and palate, 46% cleft palate), 25.9% were underweight at 4 months. The strongest predictors were early (0-3 months) growth measures: mean WAZ (58% of predictive value), WAZ velocity, mean length-for-age z-score (LAZ), and LAZ velocity, plus the Child Opportunity Index (a neighborhood socioeconomic measure; approximately 2%). These 5 predictors accounted for >85% of predictive value in every cleft type. All 6 models discriminated similarly (area under the receiver operating characteristic curve 0.87-0.90); GPBoost, which also accounts for hospital differences, produced risk estimates closest to the actual proportion of underweight infants.ConclusionsRoutine early-life growth measures (WAZ, LAZ, and their trajectories), together with neighborhood socioeconomic status, can identify infants with cleft at elevated risk of being underweight before 4 months, helping craniofacial and primary care teams provide timelier feeding and nutrition support and referrals to the highest-risk infants. FAU - Ormanidou, Ioanna AU - Ormanidou I AUID- ORCID: 0009-0001-3520-7269 AD - Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA, USA. RINGGOLD: 145793 FAU - Howard, Waylon AU - Howard W AD - Research Integration Hub, Seattle Children's Research Institute, Seattle, WA, USA. FAU - Bijlani, Kiley AU - Bijlani K AD - Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, USA. FAU - Denno, Donna M AU - Denno DM AD - General Pediatrics, Seattle Children's Hospital, Seattle, WA, USA. RINGGOLD: 7284 AD - Department of Pediatrics, University of Washington, Seattle, WA, USA. FAU - Amoako-Yirenkyi, Peter AU - Amoako-Yirenkyi P AD - Department of Mathematics, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. RINGGOLD: 98763 FAU - Heike, Carrie AU - Heike C AUID- ORCID: 0000-0003-2178-7730 AD - Center for Clinical and Translational Research, Seattle Children's Research Institute, Seattle, WA, USA. AD - Department of Pediatrics, University of Washington, Seattle, WA, USA. AD - Craniofacial Center, Seattle Children's Hospital, Seattle, WA, USA. FAU - Adusei, Abraham Owusu AU - Adusei AO AD - Biomedical Data Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Oliphant, Heather AU - Oliphant H AD - Data Coordinating Center, Seattle Children's Research Institute, Seattle, WA, USA. FAU - Crerand, Canice E AU - Crerand CE AUID- ORCID: 0000-0003-0040-6396 AD - Center for Biobehavioral Health, Nationwide Children's Hospital, Columbus, OH, USA. RINGGOLD: 2650 FAU - Jackson, Oksana AU - Jackson O AD - Division of Plastic, Reconstructive and Oral Surgery, Children's Hospital of Philadelphia, Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Discolo, Christopher AU - Discolo C AD - Department of Otolaryngology, Children's Hospital Colorado, Charleston, SC, USA. RINGGOLD: 2932 FAU - Vetter, Sarah AU - Vetter S AD - Rehabilitative Services, Ann & Robert H Lurie Children's, Chicago, IL, USA. RINGGOLD: 20212 FAU - Wilson, Kristina AU - Wilson K AD - Texas Children's Hospital, Houston, TX, USA. RINGGOLD: 3984 FAU - Geronimo, Yeraldi AU - Geronimo Y AUID- ORCID: 0009-0009-3702-3429 AD - Division of Plastic & Craniofacial Surgery, Nemours Children's Hospital, Orlando, FL, USA. RINGGOLD: 25104 FAU - Galera, Rhona AU - Galera R AD - Speech Language Pathology in Rehabilitation Services, Stanford Children's Hospital, Palo Alto, CA, USA. RINGGOLD: 24349 FAU - Lyman, Natalie AU - Lyman N AD - Hearing and Speech, Children's National Hospital, Washington, DC, USA. RINGGOLD: 8404 FAU - Whyte, Vanessa AU - Whyte V AD - Hearing and Speech, Children's National Hospital, Washington, DC, USA. RINGGOLD: 8404 FAU - Pajor, Nate AU - Pajor N AD - Division of Pulmonary Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. RINGGOLD: 2518 FAU - McKinney, Christy M AU - McKinney CM AUID- ORCID: 0000-0002-7767-7816 AD - Center for Child Health, Behavior and Development, Seattle Children's Research Institute, Seattle, WA, USA. RINGGOLD: 145793 AD - Department of Pediatrics, University of Washington, Seattle, WA, USA. AD - Craniofacial Center, Seattle Children's Hospital, Seattle, WA, USA. LA - eng PT - Journal Article DEP - 20261009 PL - United States TA - Cleft Palate Craniofac J JT - The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association JID - 9102566 SB - IM OTO - NOTNLM OT - anthropometry OT - cleft lip OT - cleft lip and palate OT - cleft palate OT - development EDAT- 2026/10/09 11:40 MHDA- 2026/10/09 11:40 CRDT- 2026/10/09 09:23 PHST- 2026/10/09 11:40 [medline] PHST- 2026/10/09 11:40 [pubmed] PHST- 2026/10/09 09:23 [entrez] AID - 10.1177/10556656261494318 [doi] PST - aheadofprint SO - Cleft Palate Craniofac J. 2026 Oct 9:10556656261494318. doi: 10.1177/10556656261494318. PMID- 42852721 OWN - NLM STAT- Publisher LR - 20261009 IS - 1473-0804 (Electronic) IS - 1369-7137 (Linking) DP - 2026 Oct 9 TI - Non-linear association between body roundness index and menopausal symptoms in perimenopausal and postmenopausal women. PG - 1-9 LID - 10.1080/13697137.2026.2728616 [doi] AB - OBJECTIVE: This study aimed to examine the association between body roundness index (BRI) and menopausal symptoms in Chinese perimenopausal and postmenopausal women. METHOD: The cross-sectional study enrolled 1795 perimenopausal and postmenopausal women aged 40-69 years who attended the Menopause Clinic at Guangdong Women and Children Hospital. Menopausal symptom severity was assessed using the validated Chinese-modified Kupperman Menopause Index (KMI). Multivariable logistic regression and restricted cubic splines were used to estimate odds ratios (ORs) and identify potential thresholds. RESULTS: Overall, 78.8% of participants reported menopausal symptoms, most of which were mild to moderate. Higher BRI was independently associated with higher odds of menopausal symptoms after adjustment for covariates in a multivariable logistic regression model (OR: 1.20, 95% confidence interval [CI]: 1.05-1.38, p = 0.009). Restricted cubic spline analysis revealed a non-linear relationship between BRI and menopausal symptoms (p-value for non-linearity = 0.014), with a data-derived inflection point at 2.571. Among women with BRI exceeding 2.571, the odds of menopausal symptoms increased progressively with rising BRI (OR: 1.34, 95% CI: 1.11-1.62, p = 0.002). Subgroup analyses showed consistent associations across strata (all p-values for interaction > 0.05). CONCLUSION: The BRI may serve as a useful anthropometric marker for identifying midlife women with greater symptom burden, although causal inference requires prospective validation. FAU - Lyu, Xiao AU - Lyu X AUID- ORCID: 0000-0002-4484-629X AD - Department of Women's Health Care, Guangdong Women and Children Hospital, Guangzhou, China. FAU - Chen, Guozhen AU - Chen G AD - Department of Women's Health Care, Guangdong Women and Children Hospital, Guangzhou, China. FAU - Xia, Jianhong AU - Xia J AUID- ORCID: 0000-0001-8150-2667 AD - Department of Women's Health Care, Guangdong Women and Children Hospital, Guangzhou, China. LA - eng PT - Journal Article DEP - 20261009 PL - England TA - Climacteric JT - Climacteric : the journal of the International Menopause Society JID - 9810959 SB - IM OAB - This study explored whether the body roundness index (BRI), a simple measure of body shape based on waist size and height, is associated with menopausal symptoms. Among women attending a menopause clinic in China, higher BRI was linked to an increased likelihood of reporting menopausal symptoms, especially above a certain BRI threshold. Because the study was cross-sectional, it cannot establish that higher BRI causes symptoms, but the results suggest that central body fat may be important when evaluating women during the menopausal transition. OABL- eng OTO - NOTNLM OT - Body roundness index OT - body fat distribution OT - cross-sectional study OT - menopausal symptoms OT - obesity OT - visceral adiposity EDAT- 2026/10/09 11:40 MHDA- 2026/10/09 11:40 CRDT- 2026/10/09 07:55 PHST- 2026/10/09 11:40 [medline] PHST- 2026/10/09 11:40 [pubmed] PHST- 2026/10/09 07:55 [entrez] AID - 10.1080/13697137.2026.2728616 [doi] PST - aheadofprint SO - Climacteric. 2026 Oct 9:1-9. doi: 10.1080/13697137.2026.2728616. PMID- 42850777 OWN - NLM STAT- Publisher LR - 20261009 IS - 1941-2452 (Electronic) IS - 0884-5336 (Linking) DP - 2026 Oct 8 TI - Diagnostic accuracy of gastric aspirate pH measurement for verifying nasogastric tube placement in children receiving home enteral nutrition: An observational diagnostic accuracy study. LID - 10.1002/ncp.70185 [doi] AB - BACKGROUND: Accurate verification of nasogastric (NG) tube placement is essential to prevent complications. Although radiography remains the reference standard, repeated imaging is impractical for children receiving home enteral nutrition. Gastric aspirate pH measurement is recommended as the preferred bedside method, but evidence of its diagnostic accuracy in pediatric home care is limited. METHODS: This observational diagnostic accuracy study included 40 children receiving home enteral nutrition via NG tubes. Gastric aspirate pH was measured once immediately before a fluoroscopic swallowing assessment scheduled as part of routine care. Standardized pH indicator strips were used, and fluoroscopic findings served as the reference standard. Receiver operating characteristic (ROC) analysis was performed to identify a sample-derived optimal pH cutoff. RESULTS: Fluoroscopy confirmed gastric placement in 27 children (67.5%) and nongastric placement in 13 (32.5%), including high and duodenal tube positions. Gastric pH values were lower than those in nongastric placements (P < 0.001). ROC analysis identified a sample-derived cutoff of 5.65. At the prespecified internationally recommended clinical threshold of  250 IU/mL) and nutritional deficiency (Vitamin D < 20 ng/mL). Furthermore, Decision Curve Analysis (DCA) demonstrated substantial net clinical benefit for triage application. CONCLUSION: We established a highly robust, interpretable machine learning algorithm capable of accurately stratifying ADHD risk among AR children. The identified neuro-immune synergistic phenotypes provide critical mechanistic insights and offer a practical decision-support tool for timely pediatric multidisciplinary interventions. CI - Copyright (c) 2026 Yuan and Wu. FAU - Yuan, Hexiu AU - Yuan H AD - Ganzhou Hospital-Nanfang Hospital, Southern Medical University (Ganzhou People's Hospital), Ganzhou, China. FAU - Wu, Nengjing AU - Wu N AD - First Affiliated Hospital of Gannan Medical University, Ganzhou, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260923 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/epidemiology MH - *Rhinitis, Allergic/epidemiology MH - Comorbidity MH - Child MH - Boosting Machine Learning Algorithms MH - Female MH - Predictive Learning Models MH - *Machine Learning MH - Male MH - Adolescent PMC - PMC13642325 OTO - NOTNLM OT - SHAP OT - allergic rhinitis OT - attention-deficit/hyperactivity disorder OT - machine learning OT - neuro-immune crosstalk COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/08 17:35 MHDA- 2026/10/08 17:36 PMCR- 2026/09/23 CRDT- 2026/10/08 11:06 PHST- 2026/03/23 00:00 [received] PHST- 2026/08/10 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/08 17:36 [medline] PHST- 2026/10/08 17:35 [pubmed] PHST- 2026/10/08 11:06 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1837156 [doi] PST - epublish SO - Front Public Health. 2026 Sep 23;14:1837156. doi: 10.3389/fpubh.2026.1837156. eCollection 2026. PMID- 42845756 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261009 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Digital health literacy moderates the school sports environment and physical activity pathway among Chinese adolescents: a health equity perspective. PG - 1967478 LID - 10.3389/fpubh.2026.1967478 [doi] LID - 1967478 AB - BACKGROUND: Physical inactivity among Chinese adolescents remains a pressing public health concern, with pronounced urban-rural disparities. School sports environments serve as a critical determinant of adolescent physical activity (PA), yet the conditions under which this relationship strengthens or weakens remain insufficiently understood. Digital health literacy (DHL) has emerged as a potential moderator that may amplify or buffer environmental influences on PA behavior. METHODS: A cross-sectional survey was conducted among 2,531 adolescents (M(age) = 15.2 +/- 1.8 years; 51.3% male) recruited through stratified cluster sampling from 18 secondary schools in Hubei Province, China (9 urban, 9 rural). Participants completed validated Chinese versions of the Questionnaire Assessing School Physical Activity Environment (Q-SPACE-Chi), the eHealth Literacy Scale (eHEALS), and the International Physical Activity Questionnaire-Short Form (IPAQ-SF). Structural equation modeling with a latent interaction term tested the moderating role of DHL, and multigroup analysis examined urban-rural differences. Reporting followed the STROBE guideline. RESULTS: School sports environment was positively associated with PA levels (beta = 0.34, p < 0.001). DHL significantly moderated this pathway (interaction beta = 0.12, p = 0.003), such that the environment-PA association was stronger among adolescents with higher DHL. Multigroup analysis revealed a significantly stronger environmental effect in urban (beta = 0.38) than in rural schools (beta = 0.29; z = 2.87, p = 0.004); the DHL moderation was significant in urban (beta = 0.14, p = 0.008) but not rural schools (beta = 0.07, p = 0.14), and the between-group difference in the moderation effect was not significant (z = 0.99, p = 0.32). The model demonstrated acceptable fit (chi (2)/df = 3.12, CFI = 0.94, TLI = 0.93, RMSEA = 0.045, SRMR = 0.041). CONCLUSION: DHL amplifies the translation of favorable school sports environments into actual PA engagement, and the environment-PA association was stronger in urban schools. These findings suggest a potential pathway through which digital inequities may contribute to PA disparities, a possibility that requires longitudinal confirmation, and underscore the need for integrated school-based and digital literacy interventions to advance health equity. CI - Copyright (c) 2026 Zhang. FAU - Zhang, Bing AU - Zhang B AD - School of Physical Education, Huanggang Normal University, Huanggang, Hubei, China. LA - eng PT - Journal Article DEP - 20260923 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - Male MH - China MH - Cross-Sectional Studies MH - *Health Literacy/statistics & numerical data MH - Female MH - *Schools MH - *Exercise MH - *Sports MH - Digital Health MH - Surveys and Questionnaires MH - *Health Equity MH - Rural Population/statistics & numerical data MH - Urban Population/statistics & numerical data PMC - PMC13642271 OTO - NOTNLM OT - adolescents OT - digital health literacy OT - health equity OT - physical activity OT - school sports environment OT - social ecological model OT - urban-rural disparity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/08 11:39 MHDA- 2026/10/08 11:40 PMCR- 2026/09/23 CRDT- 2026/10/08 08:26 PHST- 2026/08/14 00:00 [received] PHST- 2026/09/05 00:00 [revised] PHST- 2026/09/08 00:00 [accepted] PHST- 2026/10/08 11:40 [medline] PHST- 2026/10/08 11:39 [pubmed] PHST- 2026/10/08 08:26 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1967478 [doi] PST - epublish SO - Front Public Health. 2026 Sep 23;14:1967478. doi: 10.3389/fpubh.2026.1967478. eCollection 2026. PMID- 42845237 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261020 IS - 1949-0984 (Electronic) IS - 1949-0976 (Print) IS - 1949-0976 (Linking) VI - 18 IP - 1 DP - 2026 Dec 31 TI - Gut microbial metabolism of peanuts generates immunoregulatory metabolites. PG - 2743944 LID - 10.1080/19490976.2026.2743944 [doi] LID - 2743944 AB - Early life introduction of potentially allergenic foods such as peanuts is important for the prevention of food allergy. We hypothesized that peanut consumption may indirectly influence the immune system via effects on gut microbiota composition and metabolism. In vitro human fecal fermentations with peanuts were performed. Changes in taxa and metabolism were measured using 16S rRNA gene sequencing and untargeted metabolomics respectively. Ten Bifidobacterium strains were cultured in vitro in the presence of peanuts and human peripheral blood mononuclear cells (PBMCs) were used to assess culture supernatant immunomodulatory effects. Fecal samples were sequenced from children at 12 months (n = 343) using whole genome metagenomic sequencing. An online questionnaire was used to collect dietary data. Human fecal bioreactor fermentation of peanut flour, previously subjected to in vitro simulated gastrointestinal digestion, resulted in significant production of short-chain fatty acids (SCFA), associated with increased relative abundance of Megasphaera and bifidobacteria. 188 metabolites were significantly altered following peanut fermentation. Bifidobacterium longum subspecies longum strain 160 efficiently metabolized peanut associated with secretion of indole-3-lactic acid (ILA). Following growth on peanuts, bifidobacterial supernatants enhanced IL-10 secretion, but reduced TNF-alpha and IL-5 secretion from stimulated PBMCs. Peanut consumption by 12-month-old children was associated with significant changes in gut microbiota composition including increased levels of Prevotella buccae, Megasphaera micronuciformis and Blautia wexlerae. Peanuts are metabolized by microbes generating immunoregulatory metabolites such as SCFAs and ILA. These metabolites may represent one potential mechanism underlying the allergy-protective effects of early peanut consumption, which requires further validation in high-risk allergy cohorts. FAU - Shannon, Emer AU - Shannon E AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. FAU - Devotta, Hannah AU - Devotta H AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. FAU - Ndwandwe, Cebile AU - Ndwandwe C AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. FAU - Kim, Songhui AU - Kim S AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. FAU - Yao, Lu AU - Yao L AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. FAU - Kareem, Lamiah AU - Kareem L AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. FAU - Walters, Avril AU - Walters A AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. FAU - Korpela, Katri AU - Korpela K AUID- ORCID: 0000-0001-5031-2713 AD - Department of Bacteriology and Immunology, Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Hurley, Sadhbh AU - Hurley S AD - Department of Paediatrics, Cork University Hospital, University College Cork, Cork, Ireland. FAU - Lunjani, Nonhlanhla AU - Lunjani N AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - University of Cape Town, Cape Town, South Africa. FAU - Koc, Fatma AU - Koc F AD - Teagasc Food Research Centre, Fermoy, Ireland. FAU - Mathur, Harsh AU - Mathur H AD - Teagasc Food Research Centre, Fermoy, Ireland. FAU - Ambikan, Anoop AU - Ambikan A AD - The Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, ANA Futura, Stockholm, Sweden. FAU - Neogi, Ujjwal AU - Neogi U AD - The Systems Virology Lab, Division of Clinical Microbiology, Department of Laboratory Medicine, Karolinska Institute, ANA Futura, Stockholm, Sweden. FAU - Friess, Lisa AU - Friess L AUID- ORCID: 0000-0001-7945-2875 AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. FAU - van Sinderen, Douwe AU - van Sinderen D AUID- ORCID: 0000-0003-1823-7957 AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. FAU - Stanton, Catherine AU - Stanton C AUID- ORCID: 0000-0002-6724-7011 AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - Teagasc Food Research Centre, Fermoy, Ireland. FAU - Venter, Carina AU - Venter C AD - Section of Allergy & Immunology, Department of Pediatrics, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, CO, USA. FAU - Walter, Jens AU - Walter J AUID- ORCID: 0000-0003-1754-172X AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. AD - Department of Medicine, University College Cork, Cork, Ireland. FAU - Hourihane, Jonathan AU - Hourihane J AD - Paediatrics and Child Health, Royal College of Surgeons in Ireland, Dublin, Ireland. AD - Children's Health Ireland, Dublin, Ireland. FAU - O'Mahony, Liam AU - O'Mahony L AUID- ORCID: 0000-0003-4705-3583 AD - APC Microbiome Ireland, University College Cork, Cork, Ireland. AD - School of Microbiology, University College Cork, Cork, Ireland. AD - Department of Medicine, University College Cork, Cork, Ireland. LA - eng PT - Journal Article DEP - 20261008 PL - United States TA - Gut Microbes JT - Gut microbes JID - 101495343 RN - 5SW11R7M7M (indole-3-lactic acid) RN - 0 (Fatty Acids, Volatile) RN - 0 (Indoles) SB - IM MH - *Gastrointestinal Microbiome/immunology MH - *Arachis/immunology/metabolism MH - Feces/microbiology MH - Immune Tolerance MH - *Peanut Hypersensitivity/microbiology/prevention & control MH - Fermentation MH - Bifidobacterium/metabolism MH - Humans MH - Infant MH - Fatty Acids, Volatile/metabolism MH - Indoles PMC - PMC13652054 OTO - NOTNLM OT - Microbiota OT - allergy OT - complementary feeding OT - infants OT - peanuts COIS- C. Venter reports research grants from Reckitt, and Global parents for eczema research, and contributed to speakers' bureau for Reckitt, Nestle Nutrition Institute, Novalac, Danone and Abbott Nutrition. L. O'Mahony reports research grants from Chiesi, Reckitt and Fonterra, and participation in speaker bureau for Nestle, Yakult, Reckitt and Abbott. J. Hourihane is a board member of Clemens Von Pirquet Foundation and receives research funding and speaker fees from DBV Technologies and research funding from City of Dublin Skin and Cancer Hospital Charity and Kenvue. C. Stanton reports research grants from Nestle and IFF. U. Neogi received travel support from Olink Ab, Sweden. No potential conflicts of interest were disclosed for the remaining authors. EDAT- 2026/10/08 11:39 MHDA- 2026/10/08 11:40 PMCR- 2026/10/08 CRDT- 2026/10/08 05:10 PHST- 2026/10/08 11:40 [medline] PHST- 2026/10/08 11:39 [pubmed] PHST- 2026/10/08 05:10 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - 2743944 [pii] AID - 10.1080/19490976.2026.2743944 [doi] PST - ppublish SO - Gut Microbes. 2026 Dec 31;18(1):2743944. doi: 10.1080/19490976.2026.2743944. Epub 2026 Oct 8. PMID- 42845143 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261008 IS - 1399-3038 (Electronic) IS - 0905-6157 (Linking) VI - 37 IP - 10 DP - 2026 Oct TI - Machine learning-based prediction of food sensitization in infants and toddlers with atopic dermatitis. PG - e70518 LID - 10.1111/pai.70518 [doi] AB - BACKGROUND: Food sensitization (FS) is a common comorbidity in children with atopic dermatitis (AD), often leading to the atopic march. Identifying high-risk patients in primary care is crucial to prioritize specialist referrals and prevent unnecessary elimination diets. OBJECTIVE: To develop and validate a machine learning (ML) based clinical decision support tool to predict IgE-mediated FS risk in infants and toddlers (0-3 years) diagnosed with AD using routine clinical and laboratory parameters. METHODS: We conducted a retrospective cohort study of children diagnosed with AD. Patients were classified as FS positive or FS negative based on specific IgE levels and skin prick tests. Ten ML algorithms were trained and compared using 5-fold stratified cross-validation. Feature importance was analyzed, and an interactive web-based tool was developed for clinical application. RESULTS: Among 340 patients, 156 (45.8%) had IgE-mediated FS. Key independent predictors of FS included higher total IgE levels, younger age at presentation, elevated eosinophil counts, and breastfeeding at the time of symptom onset. Boosting-based models achieved superior performance; specifically, the AdaBoost model demonstrated high stability and discrimination (ROC AUC: 0.815 in CV and 0.819 in the held-out test set). By optimizing the probability threshold to 0.40, the model achieved a recall of 92% and an F1-score of 0.75, effectively minimizing false negatives. CONCLUSION: The ML model may serve as a screening and risk-stratification tool for IgE-mediated FS in children with AD. By utilizing routine laboratory data, this web-integrated tool can support primary care physicians in risk stratification, ensuring timely referral for high-risk cases while reducing unnecessary testing in low-risk infants. CI - (c) 2026 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. FAU - Yildirim, Riza AU - Yildirim R AUID- ORCID: 0009-0000-2675-1150 AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. FAU - Senbaykal Yigit, Ece AU - Senbaykal Yigit E AUID- ORCID: 0000-0001-6927-1261 AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. FAU - Safak, Ikbal Nur AU - Safak IN AUID- ORCID: 0000-0002-2748-4274 AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. FAU - Demirtas, Hatemi Esam AU - Demirtas HE AUID- ORCID: 0009-0005-4377-3710 AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. FAU - Pakel, Ayse AU - Pakel A AUID- ORCID: 0000-0002-4422-7595 AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. FAU - Tunca, Seda AU - Tunca S AUID- ORCID: 0000-0003-3193-1062 AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. FAU - Eren Akarcan, Sanem AU - Eren Akarcan S AUID- ORCID: 0000-0002-2170-765X AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. FAU - Akay Haci, Idil AU - Akay Haci I AUID- ORCID: 0000-0002-0965-0726 AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. FAU - Taskirdi, Ilke AU - Taskirdi I AUID- ORCID: 0000-0001-9326-2541 AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey. FAU - Tuncel, Tuba AU - Tuncel T AUID- ORCID: 0000-0002-9377-6750 AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Izmir City Hospital, Izmir, Turkey. AD - Division of Pediatric Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, Izmir Katip Celebi University, Izmir, Turkey. LA - eng PT - Journal Article PL - England TA - Pediatr Allergy Immunol JT - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JID - 9106718 RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Humans MH - Infant MH - *Dermatitis, Atopic/diagnosis/immunology/epidemiology MH - Child, Preschool MH - Male MH - Female MH - *Food Hypersensitivity/diagnosis/epidemiology/immunology MH - Immunoglobulin E/blood MH - Retrospective Studies MH - *Machine Learning MH - Predictive Learning Models MH - Infant, Newborn MH - Skin Tests MH - Boosting Machine Learning Algorithms MH - Classification Algorithms MH - Prediction Algorithms OTO - NOTNLM OT - atopic dermatitis OT - children OT - food sensitization OT - machine learning OT - risk stratification EDAT- 2026/10/08 05:31 MHDA- 2026/10/08 05:32 CRDT- 2026/10/08 04:12 PHST- 2026/09/16 00:00 [revised] PHST- 2026/05/13 00:00 [received] PHST- 2026/09/29 00:00 [accepted] PHST- 2026/10/08 05:32 [medline] PHST- 2026/10/08 05:31 [pubmed] PHST- 2026/10/08 04:12 [entrez] AID - 10.1111/pai.70518 [doi] PST - ppublish SO - Pediatr Allergy Immunol. 2026 Oct;37(10):e70518. doi: 10.1111/pai.70518. PMID- 42845016 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261008 IS - 1532-2998 (Electronic) IS - 1532-3005 (Linking) VI - 42 IP - 5 DP - 2026 Oct TI - Decoding the Anxiety Burden in Asia and Developing an XGBoost-Based Online Screening Tool Using Korean Data. PG - e70231 LID - 10.1002/smi.70231 [doi] AB - Anxiety disorders impose a substantial burden across Asia, yet comprehensive regional surveillance remains limited. In addition, the utility of the Health-Related Quality of Life Instrument with 8 Items (HINT-8) for anxiety screening in the Korean population has not been fully clarified. This study integrated data from Global Burden of Disease (GBD) 2021 and Korea National Health and Nutrition Examination Survey (KNHANES) to comprehensively assess the prevalence, incidence, and disability-adjusted life year (DALY) rates of Anxiety disorders across 48 Asian countries and territories from 1990 to 2021. Joinpoint regression, age-period-cohort modelling, decomposition analysis, and health inequality indices were employed to analyse trends and driving factors. In the Korean dataset, eight machine learning algorithms were compared. SHAP analysis was used to interpret the results, and the best-performing model was ultimately developed into an online prediction model. In 2021, Asia accounted for over half of global anxiety cases, and age-standardized rates increased by 14.6%-17.1% since 1990. After 2019, incidence (APC = 9.532%) and DALY rates (APC = 9.157%) rose sharply. Burden patterns varied by sex and age, and population growth was a major driver. In the Korean dataset, XGBoost showed the best performance (AUC = 0.894). An 8-feature parsimonious model performed comparably to the 17-feature model while improving interpretability and practical feasibility. Asia's growing anxiety burden demands prioritised care for women, adolescents, and middle-aged populations and better crisis mental health services. A Korean machine-learning tool shows potential but requires broader Asian validation. CI - (c) 2026 John Wiley & Sons Ltd. All rights reserved, including rights for text and data mining and training of artificial intelligence technologies or similar technologies. FAU - Cao, Runmin AU - Cao R AUID- ORCID: 0000-0002-8173-2961 AD - Clinical Medical College, Jinzhou Medical University, Jinzhou, Liaoning Province, China. FAU - Zhang, Yurun AU - Zhang Y AUID- ORCID: 0009-0008-7335-9272 AD - Rehabilitation Therapy, Shandong XIANDAI University, Jinan City, Shandong Province, China. FAU - Cao, Ling AU - Cao L AD - Jieshou City Center for Disease Control and Prevention, Fuyang City, Anhui Province, China. FAU - Jiang, Honghe AU - Jiang H AUID- ORCID: 0009-0007-3799-7202 AD - Department of Clinical Medicine, Anhui University of Science and Technology, Huainan City, Anhui Province, China. LA - eng PT - Journal Article PL - England TA - Stress Health JT - Stress and health : journal of the International Society for the Investigation of Stress JID - 101089166 SB - IM MH - Humans MH - Female MH - Republic of Korea/epidemiology MH - *Anxiety Disorders/epidemiology/diagnosis MH - Middle Aged MH - Adult MH - Male MH - Boosting Machine Learning Algorithms MH - Incidence MH - Prevalence MH - Asia/epidemiology MH - Nutrition Surveys MH - *Mass Screening/methods MH - Aged MH - Disability-Adjusted Life Years MH - Quality of Life OTO - NOTNLM OT - Asian burden of disease OT - Korean cohort OT - anxiety disorders OT - machine learning EDAT- 2026/10/08 05:31 MHDA- 2026/10/08 05:32 CRDT- 2026/10/08 03:14 PHST- 2026/07/13 00:00 [revised] PHST- 2026/01/30 00:00 [received] PHST- 2026/10/01 00:00 [accepted] PHST- 2026/10/08 05:32 [medline] PHST- 2026/10/08 05:31 [pubmed] PHST- 2026/10/08 03:14 [entrez] AID - 10.1002/smi.70231 [doi] PST - ppublish SO - Stress Health. 2026 Oct;42(5):e70231. doi: 10.1002/smi.70231. PMID- 42845011 OWN - NLM STAT- Publisher LR - 20261008 IS - 1532-530X (Electronic) IS - 1064-0266 (Linking) DP - 2026 Oct 8 TI - Development and early implementation of a brief 2-day multidisciplinary parent training group for paediatric ARFID: A feasibility and acceptability study. PG - 1-22 LID - 10.1080/10640266.2026.2741121 [doi] AB - OBJECTIVE: Many children with avoidant/restrictive food intake disorder (ARFID) cannot access appropriate care, as existing individual and family treatments are scarce, long and costly. We developed a brief 2-day (12-h) multidisciplinary parent training group and assessed its feasibility and acceptability in routine care. METHOD: Single-arm implementation study in one tertiary centre. Parents of 18 children (5-14 years) with DSM-5 ARFID (17/18 sensory-based; non-French-speaking families excluded) attended two days three weeks apart. Guided by the RE-AIM framework, we assessed reach, feasibility (a priori benchmark >/=75% completion) and acceptability (HAQ-11S; CSQ-8; parents' written feedback). Clinician-rated severity (CGI-S) was an exploratory, uncontrolled signal. RESULTS: Of 26 eligible families, 18 (69%) enrolled and 16 (89%) completed both days, exceeding the benchmark; attendance was almost exclusively maternal (83%). HAQ-11S and CSQ-8 scores were high and increased post-program (p < .001), and all respondents rated the satisfaction questionnaire positively. Parents' immediate self-reports most often cited better understanding of the disorder, increased competence and reduced isolation. CGI-S was numerically lower afterwards but this uncontrolled change cannot be attributed to the intervention. CONCLUSION: This brief multidisciplinary parent group for paediatric ARFID is feasible and highly acceptable in this specialist setting, resource use and clinical benefit require controlled evaluation. FAU - Carletti, Leila AU - Carletti L AD - Child and Adolescent Psychiatry Department, Rare Disease Reference Center for Early-Onset Anorexia Nervosa, Robert Debre University Hospital, APHP, Paris, France. FAU - Porte, Chloe AU - Porte C AD - Child and Adolescent Psychiatry Department, Rare Disease Reference Center for Early-Onset Anorexia Nervosa, Robert Debre University Hospital, APHP, Paris, France. FAU - Helbert, Sarah AU - Helbert S AD - Child and Adolescent Psychiatry Department, Rare Disease Reference Center for Early-Onset Anorexia Nervosa, Robert Debre University Hospital, APHP, Paris, France. FAU - Hooreman, Marie AU - Hooreman M AD - Child and Adolescent Psychiatry Department, Rare Disease Reference Center for Early-Onset Anorexia Nervosa, Robert Debre University Hospital, APHP, Paris, France. FAU - Charpentier, Firiel AU - Charpentier F AD - Child and Adolescent Psychiatry Department, Rare Disease Reference Center for Early-Onset Anorexia Nervosa, Robert Debre University Hospital, APHP, Paris, France. AD - Department of Medicine, Paris Cite University, Paris, France. FAU - Delorme, Richard AU - Delorme R AD - Child and Adolescent Psychiatry Department, Rare Disease Reference Center for Early-Onset Anorexia Nervosa, Robert Debre University Hospital, APHP, Paris, France. AD - Department of Medicine, Paris Cite University, Paris, France. FAU - Stordeur, Coline AU - Stordeur C AD - Child and Adolescent Psychiatry Department, Rare Disease Reference Center for Early-Onset Anorexia Nervosa, Robert Debre University Hospital, APHP, Paris, France. FAU - Villemonteix, Thomas AU - Villemonteix T AD - Child and Adolescent Psychiatry Department, Rare Disease Reference Center for Early-Onset Anorexia Nervosa, Robert Debre University Hospital, APHP, Paris, France. AD - Department of Psychology, DysCo Lab, Paris 8 University, Paris, France. AD - Department of Psychology, Institut Universitaire de France, Paris, France. FAU - Ayrolles, Anael AU - Ayrolles A AUID- ORCID: 0000-0002-3202-0781 AD - Child and Adolescent Psychiatry Department, Rare Disease Reference Center for Early-Onset Anorexia Nervosa, Robert Debre University Hospital, APHP, Paris, France. AD - Department of Medicine, Paris Cite University, Paris, France. LA - eng PT - Journal Article DEP - 20261008 PL - United States TA - Eat Disord JT - Eating disorders JID - 9315161 SB - IM EDAT- 2026/10/08 05:31 MHDA- 2026/10/08 05:31 CRDT- 2026/10/08 03:13 PHST- 2026/10/08 05:31 [medline] PHST- 2026/10/08 05:31 [pubmed] PHST- 2026/10/08 03:13 [entrez] AID - 10.1080/10640266.2026.2741121 [doi] PST - aheadofprint SO - Eat Disord. 2026 Oct 8:1-22. doi: 10.1080/10640266.2026.2741121. PMID- 42844973 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261016 IS - 1399-3038 (Electronic) IS - 0905-6157 (Print) IS - 0905-6157 (Linking) VI - 37 IP - 10 DP - 2026 Oct TI - Feeding characteristics in young children with IgE-mediated food allergies: A cross-sectional observational study. PG - e70508 LID - 10.1111/pai.70508 [doi] LID - e70508 AB - BACKGROUND: Research is limited regarding the intersection between Immunoglobulin-E (IgE)-mediated food allergies and paediatric feeding Disorder (PFD). The impact on caregivers managing a child with both conditions also remains poorly understood. OBJECTIVE: This study aimed to explore feeding characteristics in young children with IgE-mediated food allergies to identify the proportion of children who may be at risk of PFD, and to examine associations between risk of PFD and caregiver-reported stress and feeding-related quality of life. METHODS: A cross-sectional cohort (N = 107) of caregivers of children aged 0;6-4;11 years, with at least one diagnosed IgE-mediated food allergy, was recruited from three paediatric allergy clinics. Validated caregiver-reported questionnaires were used to assess feeding behaviours, caregiver stress and feeding-related quality of life. RESULTS: Seventeen (16%) children were identified as being at risk of PFD based on the Behavioural Pediatric Feeding Assessment Scale-Total Frequency Score (BPFAS-TFS). Across the cohort, caregiver stress fell within the expected range. However, caregivers of children at risk of PFD reported significantly higher levels of stress on the Parental Stress Scale (PSS) (p < .001) and poorer feeding-related quality of life on the Feeding Swallowing-Impact Scale (FS-IS) (p < .001). CONCLUSION: Sixteen percent of children with IgE-mediated food allergies screened as being at risk of PFD, suggesting that screening and assessment of PFD are valuable in this population. More frequent difficult mealtime behaviours were associated with increased caregiver stress and lower feeding-related quality of life. Health services must recognise the compounded stressors of managing both food allergies and feeding behaviours/PFD to deliver holistic, family-centred care. CI - (c) 2026 The Author(s). Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. FAU - Kefford, Jennifer AU - Kefford J AUID- ORCID: 0000-0002-0465-6029 AD - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia. AD - Northern Sydney Local Health District, New South Wales Health, Sydney, New South Wales, Australia. FAU - Ward, Elizabeth C AU - Ward EC AUID- ORCID: 0000-0002-2680-8978 AD - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia. AD - Centre for Functioning and Health Research (CFAHR), Metro South Hospital and Health Service, Brisbane, Queensland, Australia. FAU - Packer, Rebecca L AU - Packer RL AUID- ORCID: 0000-0002-5744-7757 AD - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia. FAU - Netting, Merryn AU - Netting M AUID- ORCID: 0000-0002-0642-9145 AD - National Allergy Council, Sydney, New South Wales, Australia. AD - Department of Paediatrics, University of Adelaide, Adelaide, South Australia, Australia. FAU - Swamy, Shruti AU - Swamy S AUID- ORCID: 0009-0008-2396-3260 AD - The University of Sydney, Sydney, New South Wales, Australia. AD - Royal Prince Alfred Hospital, Sydney, New South Wales, Australia. AD - Royal North Shore Hospital, Sydney, New South Wales, Australia. AD - Sydney Children's Hospital Randwick, Sydney, New South Wales, Australia. FAU - Ford, Lara S AU - Ford LS AD - The University of Sydney, Sydney, New South Wales, Australia. AD - The Children's Hospital at Westmead, Sydney, New South Wales, Australia. FAU - Marshall, Jeanne AU - Marshall J AUID- ORCID: 0000-0003-0652-9258 AD - School of Health and Rehabilitation Sciences, The University of Queensland, Brisbane, Queensland, Australia. AD - Queensland Children's Hospital, Children's Health Queensland Hospital and Health Service, Brisbane, Queensland, Australia. LA - eng GR - Speech Pathology Australia/ PT - Journal Article PT - Observational Study PL - England TA - Pediatr Allergy Immunol JT - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JID - 9106718 RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Food Hypersensitivity/epidemiology/immunology MH - Female MH - Male MH - Child, Preschool MH - Infant MH - *Feeding Behavior MH - Immunoglobulin E/immunology/blood MH - Quality of Life MH - Caregivers/psychology MH - Stress, Psychological/epidemiology MH - Surveys and Questionnaires MH - Child MH - *Feeding and Eating Disorders of Childhood/epidemiology PMC - PMC13646849 OTO - NOTNLM OT - caregiver burden OT - feeding and eating disorders OT - feeding behaviours OT - food allergy OT - food hypersensitivity COIS- None. EDAT- 2026/10/08 05:31 MHDA- 2026/10/08 05:32 PMCR- 2026/10/08 CRDT- 2026/10/08 02:54 PHST- 2026/09/15 00:00 [revised] PHST- 2026/03/07 00:00 [received] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/10/08 05:32 [medline] PHST- 2026/10/08 05:31 [pubmed] PHST- 2026/10/08 02:54 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - PAI70508 [pii] AID - 10.1111/pai.70508 [doi] PST - ppublish SO - Pediatr Allergy Immunol. 2026 Oct;37(10):e70508. doi: 10.1111/pai.70508. PMID- 42843881 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261010 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 10 DP - 2026 Oct 7 TI - Does nicotinamide riboside supplementation increase milk production in postpartum women with infants admitted to a neonatal intensive care unit? Protocol for the MOONRISE randomised, double-blind, placebo-controlled pilot feasibility trial. PG - e118516 LID - 10.1136/bmjopen-2026-118516 [doi] LID - e118516 AB - INTRODUCTION: An adequate supply of a mother's own milk plays a critical role in optimising health outcomes for at-risk hospitalised infants. Insufficient milk production disproportionately affects the mothers of these infants. In the USA, metoclopramide is the only approved drug available for off-label use as a galactagogue. Nicotinamide riboside (NR), a direct precursor to nicotinamide adenine dinucleotide (NAD(+)), has been shown in a murine model to augment high-quality milk production and enhance cognitive and physical development of pups. Human testing with NR has been limited, and studies in lactating individuals have not been performed. The aim of this study is to assess the feasibility of NR supplementation in mothers whose infants are admitted to the neonatal intensive care unit (NICU) for at least 4 weeks. METHOD AND ANALYSIS: This double-blind, randomised, placebo-controlled pilot feasibility trial aims to investigate NR supplementation in mothers of infants who are anticipated to be hospitalised in the NICU for at least 4 weeks. We plan to enroll 40 mother-infant pairs with the expectation that 30 will complete the study (n=15 in each group). The intervention period with maternal NR supplementation or placebo supplementation and maternal milk, urine and blood sampling will be 19 days, including an enrollment day.The primary endpoint of the study includes feasibility of enrolling >/=50% of eligible mothers. Secondary endpoints include compliance, adherence or withdrawal from the protocol. Similarly, the study will assess the difference in mean milk volume, macronutrient and micronutrient content, human milk glycans, milk and urine metabolites and infant feeding practice between the two groups. Optional secondary endpoints include differences in serum prolactin, liver function, plasma lipidome, serum metabolites, serum cellular communication network factor 3 concentrations, serum NAD(+)-related precursors and intermediates between mothers of the two groups. Exploratory outcomes include changes in mothers' weight and infants' developmental and NICU outcomes. Safety endpoints include the frequency of adverse events. ETHICS AND DISSEMINATION: The Institutional Review Board (IRB) protocol version date is 1 June 2026, approved by the IRB at the University of California Davis Medical Center (approval number: 1557473). Study investigators will communicate trial results to participants, healthcare professionals and the public through peer-reviewed publications and presentations at scientific conferences. Trial results will also be reported on ClinicalTrials.gov and made available through PubMed Central, in accordance with regulatory requirements. Deidentified participant data will be available to qualified researchers upon request after publication. Approved requests will be granted access within 12 months and are subject to study team and IRB approval and a data use agreement. TRIAL REGISTRATION NUMBER: NCT04614714. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Khanal, Luna AU - Khanal L AUID- ORCID: 0009-0002-0074-5101 AD - Department of Pediatrics, University of California Davis Health, Sacramento, California, USA. FAU - Cernioglo, Karina AU - Cernioglo K AD - Department of Family Medicine, Kaiser Permanente, Sacramento, California, USA. FAU - Smilowitz, Jennifer T AU - Smilowitz JT AUID- ORCID: 0000-0003-1165-1944 AD - Department of Nutrition, University of California Davis, Davis, California, USA. FAU - German, J Bruce AU - German JB AD - Department of Food Science and Technology, University of California Davis, Davis, California, USA. AD - Foods for Health Institute, University of California Davis, Davis, California, USA. FAU - Underwood, Mark A AU - Underwood MA AD - Department of Pediatrics, University of California Davis Health, Sacramento, California, USA. FAU - Kuhn-Riordon, Kara AU - Kuhn-Riordon K AUID- ORCID: 0000-0001-7346-6299 AD - Department of Pediatrics, University of California Davis Health, Sacramento, California, USA. FAU - Cacho, Nicole T AU - Cacho NT AUID- ORCID: 0000-0002-3269-9122 AD - Department of Pediatrics, University of California Davis, Davis, California, USA ntcacho@ucdavis.edu. LA - eng SI - ClinicalTrials.gov/NCT04614714 PT - Clinical Trial Protocol PT - Journal Article DEP - 20261007 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - 25X51I8RD4 (Niacinamide) RN - 0I8H2M0L7N (nicotinamide-beta-riboside) RN - 0 (Pyridinium Compounds) SB - IM MH - Humans MH - Female MH - Double-Blind Method MH - Pilot Projects MH - *Niacinamide/analogs & derivatives/administration & dosage MH - Feasibility Studies MH - Infant, Newborn MH - *Dietary Supplements MH - Intensive Care Units, Neonatal MH - *Lactation/drug effects MH - *Milk, Human/drug effects MH - Randomized Controlled Trials as Topic MH - Postpartum Period MH - *Pyridinium Compounds/administration & dosage MH - Breast Feeding MH - Adult PMC - PMC13646992 OTO - NOTNLM OT - Neonatal intensive & critical care OT - Nutrition OT - Postpartum Women COIS- Competing interests: None declared. EDAT- 2026/10/07 23:30 MHDA- 2026/10/07 23:31 PMCR- 2026/10/07 CRDT- 2026/10/07 20:35 PHST- 2026/10/07 23:31 [medline] PHST- 2026/10/07 23:30 [pubmed] PHST- 2026/10/07 20:35 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - bmjopen-2026-118516 [pii] AID - 10.1136/bmjopen-2026-118516 [doi] PST - epublish SO - BMJ Open. 2026 Oct 7;16(10):e118516. doi: 10.1136/bmjopen-2026-118516. PMID- 42843868 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261010 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 10 DP - 2026 Oct 7 TI - Developing a youth sustainability healthy active living intervention for chronic disease prevention and environmental sustainability through community engagement and codesign: protocol for a multimethod community-based participatory research study in Canada and Jamaica. PG - e119261 LID - 10.1136/bmjopen-2026-119261 [doi] LID - e119261 AB - BACKGROUND: Most non-communicable diseases (NCDs) develop through multiple complex pathways that involve non-modifiable and modifiable risk factors. Prevention efforts optimally involve a life course approach that promotes healthy eating and physical activity because behaviours adopted early in adolescence and young adulthood are likely to be sustained and can prevent NCDs in later life. This research protocol describes a community-based co-designed study taking place in Canada and Jamaica that positions youth aged 15-25 as agents-of-change in their communities to increase knowledge and develop tools to adopt and promote sustainable practices and healthy active living. METHODS: The SCORE! Youth Sustainability Healthy Active Living (SCORE! Youth-SHAL)-Community Engagement and Co-design is a multimethod community-based participatory research (CBPR) study to be conducted in two sequential stages. Stage 1 involves community contextual mapping, a maximum of two community engagement workshops along with key informant interviews with both youth and stakeholders. Stage 2 includes a co-design workshop with local youth to develop customised healthy active living activities. Participants will be recruited using convenience and purposive sampling. Workshops and interviews will be audio-recorded and transcribed. Data will be collected to understand the SHAL intervention's feasibility, fidelity and contextual fit across diverse settings. Content and thematic analysis will occur concurrently and iteratively with data collection. ETHICS AND DISSEMINATION: This study has approval from Hamilton Integrated Research Ethics Board in Health Sciences, Brock University Research Ethics Board, The University of the West Indies-Mona Campus Research Ethics Committee, and Ministry of Health and Wellness, Jamaica-Advisory Panel on Ethics and Medico-Legal Affairs. Findings assist in finalising a SHAL intervention for youth in equity-deserving populations. We will also publish the study results in an academic journal and present at conferences, webinars and workshops. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Stennett, Rosain AU - Stennett R AUID- ORCID: 0000-0003-3386-2558 AD - Mary Heersink School of Global Health and Social Medicine, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. FAU - Kandasamy, Sujane AU - Kandasamy S AUID- ORCID: 0000-0003-4326-2783 AD - Mary Heersink School of Global Health and Social Medicine, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. AD - The Starfish Environmental Society, Hamilton, Ontario, Canada. FAU - Sherifali, Diana AU - Sherifali D AD - School of Nursing, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. FAU - de Souza, Russell J AU - de Souza RJ AUID- ORCID: 0000-0001-8945-513X AD - Mary Heersink School of Global Health and Social Medicine, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. AD - Department of Health Research Methods, Evidence, and Impact (HEI), Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. FAU - Desai, Dipika AU - Desai D AD - Department of Health Research Methods, Evidence, and Impact (HEI), Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. AD - Population Health Research Institute/Hamilton Health Sciences, Hamilton, Ontario, Canada. FAU - Kwan, Matthew Yw AU - Kwan MY AD - Department of Child and Youth Studies, Brock University, St Catharines, Ontario, Canada. AD - Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada. FAU - Smith, Joanne A AU - Smith JA AD - Epidemiology Research Unit, Caribbean Institute for Health Research, The University of the West Indies, Mona, Kingston 7, Jamaica. FAU - Edwards, Thera AU - Edwards T AD - Department of Geography and Geology, The University of the West Indies, Mona, Kingston 7, Jamaica. AD - Tropical Metabolism Research Unit, Caribbean Institute for Health Research, The University of the West Indies, Mona, Kingston 7, Jamaica. FAU - Gordon-Strachan, Georgiana AU - Gordon-Strachan G AD - Tropical Metabolism Research Unit, Caribbean Institute for Health Research, The University of the West Indies, Mona, Kingston 7, Jamaica. FAU - Bangdiwala, Shrikant I AU - Bangdiwala SI AD - Department of Health Research Methods, Evidence, and Impact (HEI), Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. AD - Population Health Research Institute/Hamilton Health Sciences, Hamilton, Ontario, Canada. FAU - Wahi, Gita AU - Wahi G AUID- ORCID: 0000-0001-5943-9702 AD - Mary Heersink School of Global Health and Social Medicine, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. AD - Department of Pediatrics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. FAU - Brook, Jeffrey AU - Brook J AD - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. FAU - Sergeant, Myles AU - Sergeant M AD - Family Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. AD - Canadian Coalition for Green Health Care, Hamilton, Ontario, Canada. FAU - Krishanthan, Alisha AU - Krishanthan A AD - Health Sciences Program, Western University, London, Ontario, Canada. FAU - Desai, Sneha AU - Desai S AD - Arts & Science Program, McMaster University, Hamilton, Ontario, Canada. FAU - Anderson, Simon G AU - Anderson SG AD - George Alleyne Chronic Disease Research Centre, Caribbean Institute for Health Research, The University of the West Indies, Bridgetown, Barbados. AD - Glasgow-Caribbean Centre for Development Research, The University of the West Indies, Mona, Kingston 7, Jamaica. FAU - Anand, Sonia S AU - Anand SS AUID- ORCID: 0000-0003-3692-7441 AD - Mary Heersink School of Global Health and Social Medicine, Department of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada anands@mcmaster.ca. AD - Population Health Research Institute/Hamilton Health Sciences, Hamilton, Ontario, Canada. LA - eng PT - Journal Article DEP - 20261007 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Community-Based Participatory Research MH - Jamaica MH - Canada MH - Adolescent MH - *Health Promotion/methods MH - Young Adult MH - Research Design MH - Chronic Disease/prevention & control MH - *Exercise MH - Female MH - *Community Participation PMC - PMC13646957 OTO - NOTNLM OT - Community Participation OT - Community-Based Participatory Research OT - QUALITATIVE RESEARCH OT - Young Adult COIS- Competing interests: RJdS has served as an external resource person to the World Health Organization's Nutrition Guidelines Advisory Group on trans fats, saturated fats, and polyunsaturated fats. The WHO paid for his travel and accommodation to attend meetings from 2012-2017 to present and discuss this work. He has also done contract research for the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism, and Diabetes, Health Canada, and the World Health Organization, for which he received remuneration. He has received speaker's fees from the University of Toronto and McMaster Children's Hospital. He has held grants from the Canadian Institutes of Health Research, Canadian Foundation for Dietetic Research, Population Health Research Institute, and Hamilton Health Sciences Corporation as a principal investigator, and is a co-investigator on several funded team grants from the Canadian Institutes of Health Research. He serves as a member of the Nutrition Science Advisory Committee to Health Canada (Government of Canada), a co-opted member of the Scientific Advisory Committee on Nutrition (SACN) Subgroup on the Framework for the Evaluation of Evidence (Public Health England), and as an independent director of the Helderleigh Foundation (Canada). SSA is an Associate Vice-President of Global Health, McMaster University and a Senior Scientist at the Population Health Research Institute. She currently serves on the Editorial Board of The British Medical Journal and is an Associate Editor of JAMA Cardiology. SSA has received grants from the Public Health Agency of Canada, Heart & Stroke, Canadian Institutes of Health Research. She has served as a Consultant and received payment/honoraria for lectures, presentations and speaker bureaus from Bayer AG, Janssen Pharmaceuticals, Novartis Pharmaceuticals Canada, Novo Nordisk Amgen, HSL Therapeutics, Daiichi Sankyo, Regeneron and Eli Lily. She has held a Tier 1 Canada Research Chair in Ethnicity and CVD (#CRC-2017-00024) for two successive terms, Heart & Stroke Foundation Chair in Population Health and Michael G. DeGroote Chair in Population Health Research. EDAT- 2026/10/07 23:30 MHDA- 2026/10/07 23:31 PMCR- 2026/10/07 CRDT- 2026/10/07 20:35 PHST- 2026/10/07 23:31 [medline] PHST- 2026/10/07 23:30 [pubmed] PHST- 2026/10/07 20:35 [entrez] PHST- 2026/10/07 00:00 [pmc-release] AID - bmjopen-2026-119261 [pii] AID - 10.1136/bmjopen-2026-119261 [doi] PST - epublish SO - BMJ Open. 2026 Oct 7;16(10):e119261. doi: 10.1136/bmjopen-2026-119261. PMID- 42843149 OWN - NLM STAT- Publisher LR - 20261022 IS - 1878-9307 (Electronic) IS - 1878-9293 (Print) IS - 1878-9293 (Linking) VI - 82 DP - 2026 Sep 21 TI - A systematic review of digital and wearable sensor data in the ABCD study: Insights, methods, and emerging opportunities. PG - 101826 LID - S1878-9293(26)00168-4 [pii] LID - 10.1016/j.dcn.2026.101826 [doi] LID - 101826 AB - Research into key adolescent health domains, like problematic screen-based media use, sleep health, and physical activity, are frequently limited by error-prone self-report-based measures. To improve the measurement of such behaviors, the Adolescent Brain Cognitive Development Study (ABCD), a diverse longitudinal cohort study of nearly 12,000 U.S. youth (ages 9-10 at Baseline), includes remote sensing protocols during data collection. Consenting participants provided up to three weeks of Fitbit actigraphy data, beginning at the year-two follow up, and smartphone usage data, beginning at the year-four follow up, collected via the Effortless Assessment of Research Systems (EARS) smartphone application. This systematic review aimed to identify and synthesize all published empirical studies which have utilized the ABCD Study's passive sensor data, identifying 45 articles investigating measurement validity, and associations with adolescent health, development, and neurocognitive functioning. Fitbit devices broadly reproduced estimates of sleep and physical activity obtained from research-grade sensors. Smartphone sensor data were internally consistent, reproduced expected daily usage patterns, and were moderately correlated with self-report. Most substantive studies utilized Fitbit data and reported cross-sectional associations between sensor-derived single-item summary statistics and survey-based measures of mental and behavioral health, neurocognitive functioning, or environmental risk factors. A smaller number of studies utilized longitudinal designs, within-person analyses, machine learning approaches, and/or genetic or neuroimaging methods to reduce confounding and enhance biological and etiological insight into these observed relationships. While published findings were largely incremental in nature, ABCD's passive sensing resources nonetheless represent a powerful, widely available resource for incorporating sensor-based measures into adolescent health research. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Alexander, Jordan D AU - Alexander JD AD - Psychology Department, University of Maine, Orono, ME, United States. Electronic address: jordan.d.alexander@maine.edu. FAU - Mills, Sawyer AU - Mills S AD - Institute for Drug and Alcohol Studies, Virginia Commonwealth University, Richmond, VA, United States. FAU - Sumpter, Kelsey AU - Sumpter K AD - School of Medicine, University of Maryland at Baltimore, Baltimore, MD, United States. FAU - Smith, Calen J AU - Smith CJ AD - J. Craig Venter Institute, La Jolla, CA, United States. FAU - Das, Biplabendu AU - Das B AD - J. Craig Venter Institute, La Jolla, CA, United States. FAU - Fan, Ruby AU - Fan R AD - Center for Health Sciences, SRI International, Menlo Park, CA, United States. FAU - Hunt, Ethan T AU - Hunt ET AD - University of Texas Health Science Center at Houston (UTHealth) School of Public Health - Austin Campus, Austin, TX, United States. FAU - Brown, Sandra A AU - Brown SA AD - Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States. FAU - Curtis, Brenda L AU - Curtis BL AD - National Institute on Drug Abuse Intramural Research Program, Baltimore, MD, United States. FAU - Cummins, Kevin M AU - Cummins KM AD - Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States. FAU - Mason, Michael AU - Mason M AD - Center for Behavioral Health Research, University of Tennessee Knoxville, Knoxville, TN, United States. FAU - Neale, Michael C AU - Neale MC AD - Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, United States. FAU - Tapert, Susan F AU - Tapert SF AD - Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States. FAU - Baker, Fiona C AU - Baker FC AD - Center for Health Sciences, SRI International, Menlo Park, CA, United States. FAU - Fuemmeler, Bernard F AU - Fuemmeler BF AD - Department of Family Medicine and Population Health, Virginia Commonwealth University, Richmond, VA, United States. FAU - Wade, Natasha E AU - Wade NE AD - Department of Psychiatry, University of California, San Diego, La Jolla, CA, United States. LA - eng GR - U24 DA041147/DA/NIDA NIH HHS/United States GR - U01 DA051039/DA/NIDA NIH HHS/United States GR - U01 DA041120/DA/NIDA NIH HHS/United States GR - K08 DA050779/DA/NIDA NIH HHS/United States GR - U01 DA051018/DA/NIDA NIH HHS/United States GR - U01 DA041093/DA/NIDA NIH HHS/United States GR - U24 DA041123/DA/NIDA NIH HHS/United States GR - U01 DA051038/DA/NIDA NIH HHS/United States GR - U01 DA051037/DA/NIDA NIH HHS/United States GR - U01 DA051016/DA/NIDA NIH HHS/United States GR - U01 DA041106/DA/NIDA NIH HHS/United States GR - U01 DA041117/DA/NIDA NIH HHS/United States GR - T32 DA050560/DA/NIDA NIH HHS/United States GR - U01 DA041174/DA/NIDA NIH HHS/United States GR - U01 DA041134/DA/NIDA NIH HHS/United States GR - U01 DA041022/DA/NIDA NIH HHS/United States GR - U01 DA041156/DA/NIDA NIH HHS/United States GR - U01 DA050987/DA/NIDA NIH HHS/United States GR - U01 DA041025/DA/NIDA NIH HHS/United States GR - U01 DA050989/DA/NIDA NIH HHS/United States GR - U01 DA041089/DA/NIDA NIH HHS/United States GR - U01 DA050988/DA/NIDA NIH HHS/United States GR - U01 DA041028/DA/NIDA NIH HHS/United States GR - U01 DA041048/DA/NIDA NIH HHS/United States GR - ZIA DA000628/ImNIH/Intramural NIH HHS/United States GR - U01 DA041148/DA/NIDA NIH HHS/United States PT - Journal Article DEP - 20260921 PL - Netherlands TA - Dev Cogn Neurosci JT - Developmental cognitive neuroscience JID - 101541838 SB - IM PMC - PMC13676921 OTO - NOTNLM OT - Adolescent development OT - Fitbit OT - Passive Sensing OT - Physical Activity OT - Sensor based data OT - Sleep OT - Smartphone Use COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/07 23:30 MHDA- 2026/10/07 23:30 PMCR- 2026/09/21 CRDT- 2026/10/07 18:09 PHST- 2025/12/01 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/10/07 23:30 [medline] PHST- 2026/10/07 23:30 [pubmed] PHST- 2026/10/07 18:09 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - S1878-9293(26)00168-4 [pii] AID - 101826 [pii] AID - 10.1016/j.dcn.2026.101826 [doi] PST - aheadofprint SO - Dev Cogn Neurosci. 2026 Sep 21;82:101826. doi: 10.1016/j.dcn.2026.101826. PMID- 42842533 OWN - NLM STAT- Publisher LR - 20261020 IS - 1423-0097 (Electronic) IS - 1018-2438 (Linking) DP - 2026 Oct 7 TI - Clinical and Immunological Determinants of Time to Open Oral Food Challenge-Confirmed Tolerance in Children with IgE-Mediated Food Allergy: A Retrospective Cohort Study. PG - 1 LID - 10.1159/iaa/adfag028 [doi] AB - INTRODUCTION: The timing of tolerance acquisition in childhood IgE-mediated food allergy is clinically important but has been less well studied than persistence as a binary outcome. We examined clinical and immunological determinants of time to open oral food challenge (OFC)-confirmed tolerance. METHODS: This retrospective cohort study included 157 children with physician-established IgE-mediated food allergy evaluated at a tertiary pediatric allergy clinic between January 2023 and July 2026. Time zero was defined as elimination-diet initiation; tolerance was defined exclusively by a successful supervised open OFC. One mutually exclusive index allergen was assigned to each child and used consistently to define the time-to-tolerance outcome. Kaplan-Meier analysis and parametric accelerated failure time (AFT) models were used. The log-logistic model, adjusted for index allergen and the prespecified clinical and immunological covariates, was selected for multivariable analysis and internally validated using 1,000 bootstrap resamples. RESULTS: Of 157 children, 120 achieved OFC-confirmed tolerance and 37 were right-censored. The mutually exclusive index-allergen distribution was hen's egg (n = 103), cow's milk (n = 35), tree nut (n = 16), other food (n = 2), and fish (n = 1). In the index-allergen-adjusted log-logistic AFT model, food-induced anaphylaxis (adjusted time ratio [TR]: 2.13, 95% CI: 1.34-3.36; p = 0.001), allergic rhinitis (adjusted TR: 1.80, 95% CI: 1.26-2.55; p = 0.001), and each 10-fold increase in total IgE (adjusted TR: 1.54, 95% CI: 1.20-1.98; p < 0.001) were associated with a longer time to tolerance. Tree-nut index allergy was also associated with longer time to tolerance than hen's egg (adjusted TR: 2.74, 95% CI: 1.19-6.29; p = 0.018), although this estimate was based on few tolerance events. CONCLUSION: Previous food-induced anaphylaxis, allergic rhinitis, higher total IgE, and index food type were associated with the timing of open OFC-confirmed tolerance in children with IgE-mediated food allergy. Routine quantitative IgG, IgA, and IgM measures were not independently associated with tolerance timing. CI - (c) The Author(s) 2026. Published by S. Karger AG. FAU - Kangalli Boyacioglu, Ozge AU - Kangalli Boyacioglu O FAU - Soyoz, Ozgen AU - Soyoz O FAU - Erdem Bahceci, Semiha AU - Erdem Bahceci S LA - eng PT - Journal Article DEP - 20261007 PL - Switzerland TA - Int Arch Allergy Immunol JT - International archives of allergy and immunology JID - 9211652 SB - IM OTO - NOTNLM OT - Anaphylaxis OT - Food tolerance OT - IgE-mediated food allergy OT - Oral food challenge OT - Survival analysis OT - Total IgE EDAT- 2026/10/07 17:33 MHDA- 2026/10/07 17:33 CRDT- 2026/10/07 13:28 PHST- 2026/08/04 00:00 [received] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/10/07 17:33 [pubmed] PHST- 2026/10/07 17:33 [medline] PHST- 2026/10/07 13:28 [entrez] AID - 000554585 [pii] AID - 10.1159/iaa/adfag028 [doi] PST - aheadofprint SO - Int Arch Allergy Immunol. 2026 Oct 7:1. doi: 10.1159/iaa/adfag028. PMID- 42840287 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261007 LR - 20261008 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Implementation of a non-separation pathway for late preterm infants in a tertiary care center: a prospective feasibility study. PG - 1919628 LID - 10.3389/fped.2026.1919628 [doi] LID - 1919628 AB - BACKGROUND: Late preterm infants (34 + 0-36 + 6 weeks' gestation) are at increased risk of feeding difficulties, hypoglycemia, hypothermia, and early mother-infant separation. Although skin-to-skin contact and rooming-in are recommended components of family-centered neonatal care, evidence regarding the implementation of integrated non-separation strategies in late preterm infants remains limited. This study evaluated the implementation, feasibility, safety, and early clinical outcomes of a Non-Separation Pathway in a tertiary care setting. METHODS: We conducted a prospective observational cohort study after implementation of a Non-Separation Pathway at a Belgian tertiary university hospital. Mother-infant dyads with infants born between 34 + 0 and 36 + 6 weeks' gestation were enrolled between April 2023 and March 2024. The pathway consists of three interconnected components: (1) immediate and sustained delivery-room SSC, (2) continuous rooming-in, and (3) structured feeding support according to a standardized protocol based on Academy of Breastfeeding Medicine. Primary outcomes were pathway implementation, feasibility, and safety, with complete non-separation as the primary implementation outcome. Secondary outcomes included feeding practices, hypoglycemia, weight loss, length of stay, and feeding status at discharge. RESULTS: Sixty-nine mother-infant dyads were included. Mean gestational age was 35.6 weeks and mean birth weight was 2,502 g. Complete non-separation was achieved in 37.3% of dyads, delivery room skin-to-skin contact in 82.6%. Vaginal birth (aOR 5.12, 95% CI 1.51-17.39) and higher gestational age (aOR 2.14, 95% CI 1.06-4.35) were independently associated with complete non-separation. Respiratory support was independently associated with lower odds of delivery-room skin-to-skin contact (aOR 0.04, 95% CI 0.004-0.41). Hypothermia occurred in 18.8% of infants and was associated with surrogate skin-to-skin contact (aOR 6.67, 95% CI 1.71-26.03). At discharge, 75.4% of infants received any mother's milk and 34.8% were exclusively breastfed. CONCLUSIONS: Implementation of the Non-Separation Pathway demonstrated that delivery-room SSC was feasible for most late preterm infants in a tertiary neonatal setting and was not associated with major safety concerns. However, complete non-separation throughout hospitalization was achieved in only 37% of dyads and remained constrained by respiratory support requirements, cesarean delivery, maternal and neonatal complexity, limited intermediate-care capacity, and the absence of rooming-in facilities in the NICU. CI - (c) 2026 Janssens and Eerdekens. FAU - Janssens, Elien AU - Janssens E AD - Department of Pediatrics and Neonatology, Residency Program, University Hospital Leuven, Leuven, Belgium. FAU - Eerdekens, An AU - Eerdekens A AD - Neonatology Department, University Hospital Leuven -KU Leuven, Leuven, Belgium. LA - eng PT - Journal Article DEP - 20260922 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13638661 OTO - NOTNLM OT - breastfeeding OT - family-centered care OT - late preterm infant OT - neonatal outcomes OT - non-separation OT - rooming-in OT - skin-to-skin contact COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/07 11:32 MHDA- 2026/10/07 11:33 PMCR- 2026/09/22 CRDT- 2026/10/07 07:55 PHST- 2026/06/25 00:00 [received] PHST- 2026/08/02 00:00 [revised] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/10/07 11:33 [medline] PHST- 2026/10/07 11:32 [pubmed] PHST- 2026/10/07 07:55 [entrez] PHST- 2026/09/22 00:00 [pmc-release] AID - 10.3389/fped.2026.1919628 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 22;14:1919628. doi: 10.3389/fped.2026.1919628. eCollection 2026. PMID- 42840151 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261007 LR - 20261008 IS - 2251-6581 (Print) IS - 2251-6581 (Electronic) IS - 2251-6581 (Linking) VI - 25 IP - 2 DP - 2026 Dec TI - Empirical dietary and lifestyle indices for hyperinsulinemia and insulin resistance in relation to metabolic health in overweight and obese children and adolescents. PG - 282 LID - 10.1007/s40200-026-02096-y [doi] LID - 282 AB - PURPOSE: Empirical dietary and lifestyle indices reflecting hyperinsulinemia and insulin resistance have been associated with adverse metabolic outcomes in adults, but pediatric evidence is limited. We examined associations with metabolic health phenotypes in youth with excess weight. METHODS: In this cross-sectional study, 427 Iranian participants aged 6-18 years with overweight or obesity were classified as metabolically healthy obese (MHO) or metabolically unhealthy obese (MUO) using established cardiometabolic criteria. Dietary intake was assessed with a validated food frequency questionnaire. Modified versions of the empirical dietary and lifestyle indices for hyperinsulinemia (EDIH and ELIH) and insulin resistance (EDIR and ELIR) were calculated using the components available in the Iranian FFQ. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CIs), with subgroup analyses by age and sex. RESULTS: Higher adherence to ELIH and ELIR was significantly associated with increased odds of MUO (OR for Q4 vs. Q1: 3.19 and 2.41, respectively; P-trend < 0.05), while no significant associations were observed for EDIH or EDIR. Exploratory subgroup analyses showed ELIH-MUO associations in participants aged < 10 years and boys, EDIR-MUO associations in girls, and ELIR-MUO associations in girls and, for the Q4-versus-Q1 comparison only, participants aged >/= 10 years (P-trend = 0.09). CONCLUSIONS: Higher lifestyle-based insulinemic scores, particularly ELIH and ELIR, were associated with an unfavorable metabolic phenotype in youth with excess weight. Because these modified indices are empirical biomarker-prediction tools, their component weights should not be interpreted as causal effects of individual foods. Prospective and population-specific validation studies are warranted. TRIAL REGISTRATION: Not applicable. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at https://doi.org/10.1007/s40200-026-02096-y. CI - (c) The Author(s), under exclusive licence to Tehran University of Medical Sciences 2026. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. FAU - Nikparast, Ali AU - Nikparast A AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/034m2b326. GRID: grid.411600.2 FAU - Nourian, Nazanin Zahra AU - Nourian NZ AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/034m2b326. GRID: grid.411600.2 FAU - Tabatabaeyan, Ali AU - Tabatabaeyan A AD - Department of Clinical Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Students' Research Committee, Isfahan University of Medical Sciences, Isfahan, Iran. ROR: https://ror.org/04waqzz56. GRID: grid.411036.1. ISNI: 0000 0001 1498 685X FAU - Razavi, Maryam AU - Razavi M AD - Growth and Development Research Center, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/01c4pz451. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922 FAU - Khoshnezhad Afkham, Ehsan AU - Khoshnezhad Afkham E AD - Department of Pediatrics, School of Medicine, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/01c4pz451. GRID: grid.411705.6. ISNI: 0000 0001 0166 0922 FAU - Etesami, Elahe AU - Etesami E AD - Department of Nutrition, SR.C., Islamic Azad University, Tehran, Iran. ROR: https://ror.org/01kzn7k21. GRID: grid.411463.5. ISNI: 0000 0001 0706 2472 FAU - Asghari, Golaleh AU - Asghari G AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. ROR: https://ror.org/034m2b326. GRID: grid.411600.2 LA - eng PT - Journal Article DEP - 20261005 PL - Switzerland TA - J Diabetes Metab Disord JT - Journal of diabetes and metabolic disorders JID - 101590741 PMC - PMC13638921 OTO - NOTNLM OT - Empirical dietary index OT - Hyperinsulinemia OT - Insulin resistance OT - Metabolic health OT - Pediatric obesity COIS- Competing interestsThe authors declare no competing interests. EDAT- 2026/10/07 11:32 MHDA- 2026/10/07 11:33 PMCR- 2027/10/05 CRDT- 2026/10/07 07:05 PHST- 2025/10/18 00:00 [received] PHST- 2026/09/28 00:00 [accepted] PHST- 2026/10/07 11:33 [medline] PHST- 2026/10/07 11:32 [pubmed] PHST- 2026/10/07 07:05 [entrez] PHST- 2027/10/05 00:00 [pmc-release] AID - 2096 [pii] AID - 10.1007/s40200-026-02096-y [doi] PST - epublish SO - J Diabetes Metab Disord. 2026 Oct 5;25(2):282. doi: 10.1007/s40200-026-02096-y. eCollection 2026 Dec. PMID- 42838807 OWN - NLM STAT- Publisher LR - 20261006 IS - 1873-4898 (Electronic) IS - 1477-5131 (Linking) DP - 2026 Sep 21 TI - Evaluation of renal functional reserve in primary vesicoureteric reflux: A cross-sectional study. PG - 106293 LID - S1477-5131(26)00572-3 [pii] LID - 10.1016/j.jpurol.2026.106293 [doi] AB - BACKGROUND: The role of renal functional reserve (RFR) in children with vesicoureteric reflux (VUR) is understudied. The objective of this study was to determine RFR [assessed by Diethylenetriaminepentaacetic acid (DTPA) scan] in patients aged 2-18 years with primary VUR. METHODS: This cross-sectional study evaluated RFR in 50 children with primary VUR. Baseline and stimulated (after 1 g/kg protein meal) GFR were measured using technetium-99m (Tc-99m) DTPA plasma clearance (Russell's two-sample method). RFR was calculated as the proportional GFR increase, with >10% defined as positive RFR and compared across grades of VUR and scars. RFR was also assessed by timed urinary creatinine clearance. RESULTS: The median age at RFR estimation was 4.3 [IQR:2.9, 8.1] years, while median age-at-diagnosis was 7 [2, 24] months. The median duration of illness was 3.6 [2.3, 6.2] years. Initial presentations included urinary tract infections (UTI) in 31 (62%) children and antenatal hydronephrosis in 18 (36%), with 90% (n = 45) having a history of prior pyelonephritis. Patients were categorized by VUR severity: unilateral low-grade (n = 7; 14%), unilateral high-grade (n = 14; 28%), bilateral high-grade (n = 26; 52%), and bilateral low-grade (n = 3; 6%). The median DTPA RFR was 13.67 [5.84, 28.27]%, with 60% (n = 30) demonstrating a positive RFR. RFR compared among children with low-grade vs high-grade VUR, demonstrated no statistically significant difference (p = 0.28). DTPA-RFR correlated weakly with timed creatinine clearance RFR (r = 0.20), which consistently overestimated RFR. The median-annual-decline rate was higher in group with absent RFR (-4.2 vs improvement of 18.25 mL/min/1.73 m(2)/year), with a median difference of 22.45 mL/min/1.73 m(2)/year (bootstrap 95% CI 4.58, 60.74), p = 0.011. CONCLUSIONS: In conclusion, preserved RFR was noted in nearly two-thirds of children with VUR, with no significant difference with disease severity. The study demonstrates that RFR can be measured using different methodologies in children with VUR and provides valuable feasibility data. CI - Copyright (c) 2026 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved. FAU - Ettiappan, Sukumar AU - Ettiappan S AD - Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. Electronic address: sukumar45.sm@gmail.com. FAU - Deepthi, Bobbity AU - Deepthi B AD - Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. Electronic address: deepu.reddy222@gmail.com. FAU - Ponnusamy, Madhusudhanan AU - Ponnusamy M AD - Department of Nuclear Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. Electronic address: freethinker_13@yahoo.co.in. FAU - Naredi, Bikash Kumar AU - Naredi BK AD - Department of Pediatric Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. Electronic address: bikashnaredi@gmail.com. FAU - Krishnasamy, Sudarsan AU - Krishnasamy S AD - Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. Electronic address: sudarsanjipmer@gmail.com. FAU - Krishnamurthy, Sriram AU - Krishnamurthy S AD - Department of Pediatrics, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India. Electronic address: drsriramk@yahoo.com. LA - eng PT - Journal Article DEP - 20260921 PL - England TA - J Pediatr Urol JT - Journal of pediatric urology JID - 101233150 SB - IM OTO - NOTNLM OT - CKD OT - DMSA OT - DTPA OT - Renal functional reserve OT - Renal scar OT - Vesicouretic reflux COIS- Conflict of interest The authors have no competing interests to declare that are relevant to the content of this article. The authors have no financial or proprietary interests in any material discussed in this article. EDAT- 2026/10/06 23:29 MHDA- 2026/10/06 23:29 CRDT- 2026/10/06 22:00 PHST- 2026/04/02 00:00 [received] PHST- 2026/09/02 00:00 [revised] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/10/06 23:29 [medline] PHST- 2026/10/06 23:29 [pubmed] PHST- 2026/10/06 22:00 [entrez] AID - S1477-5131(26)00572-3 [pii] AID - 10.1016/j.jpurol.2026.106293 [doi] PST - aheadofprint SO - J Pediatr Urol. 2026 Sep 21:106293. doi: 10.1016/j.jpurol.2026.106293. PMID- 42837523 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261008 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Oct 6 TI - Remote Longitudinal Tracking of Sleep, Depression, and Cognition Across Early Adolescence: Protocol for a Longitudinal Observational Study. PG - e86345 LID - 10.2196/86345 [doi] LID - e86345 AB - BACKGROUND: Depression in adolescents is a growing public health concern, with 3.5 million youth in the United States experiencing a depressive episode each year. When symptoms emerge in early adolescence, they can have lasting psychological, physical, and cognitive consequences, highlighting the urgent need for proactive intervention. Insufficient sleep-characterized by short duration, irregular timing, and poor quality-is bidirectionally linked to depression and associated with impaired cognitive performance. OBJECTIVE: This protocol provides the map for a study tracking sleep patterns and neurophysiology, as well as a range of depressive symptoms, and their dynamic interaction in shaping longitudinal cognitive trajectories. METHODS: Fifty-six youth aged 9 to 13 (mean 11.01, SD 1.39) years were enrolled in a longitudinal measurement burst design comprising 4 assessment waves at baseline, 4, 8, and 12 months. We recruited a sample of youth with a range of depressive symptom severity. Each wave included 7 consecutive days of monitoring during which participants used a personalized mobile health (mHealth) platform, HowRU app, developed by the study team, to report daily sleep patterns, thrice-daily ecological momentary assessments (EMAs), and completed a series of cognitive tasks. Youth and parents also completed validated psychosocial questionnaires to assess mood, behavioral concerns, mental health, and sleep. Sleep and physical activity were monitored remotely using a Garmin VivoSmart 5 watch and Interaxon Muse S headbands. Sleep-dependent cognitive performance was assessed with 2 declarative memory tasks (Word-Pair Associates task [WPA] and Minecraft Memory and Navigation [MMN] task), a procedural memory task (Motor Sequence task), and 2 executive functioning tasks (Operation Span [OSpan] task and Rule Switch task [RST]). For the memory tasks, participants completed training and immediate testing in the evening, followed by a retention test the following morning. The OSpan task and Rule Switch were administered twice daily (morning and evening). For all tasks, stimuli were randomized and counterbalanced across participants and testing sessions. RESULTS: Funding was obtained from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (grant K08 HD107161), with a budget period of August 1, 2022, to July 31, 2027. Participant enrollment occurred May 2023 through October 2024. Data collection began in July 2023 and was completed in October 2025. Study participant retention and adherence rates for sleep diaries, cognitive tasks, and questionnaires were high. Primary outcomes of the study are anticipated to be published in fall 2026. CONCLUSIONS: This protocol provides a robust and reproducible framework to longitudinally track youth with a range of depressive symptoms in the real world using mHealth platforms and wearable technology. Potential findings can support the identification of key developmental periods of vulnerability and resilience in youth, inform future sleep-based interventions to promote mental health, and optimize cognitive outcomes across early adolescence. CI - (c) Katharine C Simon, Lia Galut, Spencer Polk, Shun Iwata, Weining Shen, Mahyar Abbasian, Amir Rahmani, Uma Rao, Jessica L Borelli, Sara C Mednick. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Simon, Katharine C AU - Simon KC AUID- ORCID: 0000-0001-8149-4636 AD - Department of Pediatrics, University of California, Irvine, School of Medicine, 5141 California Ave, Irvine, CA, 92697, United States, 1 8054534462. AD - Pulmonology Department, Rady Children's Health, Children's Hospital of Orange County, Orange, CA, United States. FAU - Galut, Lia AU - Galut L AUID- ORCID: 0009-0003-0936-4441 AD - Department of Pediatrics, University of California, Irvine, School of Medicine, 5141 California Ave, Irvine, CA, 92697, United States, 1 8054534462. AD - Pulmonology Department, Rady Children's Health, Children's Hospital of Orange County, Orange, CA, United States. FAU - Polk, Spencer AU - Polk S AUID- ORCID: 0009-0008-1878-2078 AD - Pulmonology Department, Rady Children's Health, Children's Hospital of Orange County, Orange, CA, United States. FAU - Iwata, Shun AU - Iwata S AUID- ORCID: 0009-0002-2578-8247 AD - Department of Pediatrics, University of California, Irvine, School of Medicine, 5141 California Ave, Irvine, CA, 92697, United States, 1 8054534462. FAU - Shen, Weining AU - Shen W AUID- ORCID: 0000-0003-3137-1085 AD - Department of Statistics, University of California, Irvine, Irvine, CA, United States. FAU - Abbasian, Mahyar AU - Abbasian M AUID- ORCID: 0009-0000-8448-3158 AD - Department of Computer Science, University of California, Irvine, Irvine, CA, United States. FAU - Rahmani, Amir AU - Rahmani A AUID- ORCID: 0000-0003-0725-1155 AD - School of Nursing, University of California, Irvine, Irvine, CA, United States. FAU - Rao, Uma AU - Rao U AUID- ORCID: 0000-0003-2191-279X AD - Department of Pediatrics, University of California, Irvine, School of Medicine, 5141 California Ave, Irvine, CA, 92697, United States, 1 8054534462. AD - Pulmonology Department, Rady Children's Health, Children's Hospital of Orange County, Orange, CA, United States. AD - Deparment of Psychiatry and Human Behavior, University of California, Irvine, School of Medicine, Irvine, CA, United States. AD - Department of Psychology, University of California, Irvine, Irvine, CA, United States. FAU - Borelli, Jessica L AU - Borelli JL AUID- ORCID: 0000-0001-8471-6732 AD - Department of Psychology, University of California, Irvine, Irvine, CA, United States. FAU - Mednick, Sara C AU - Mednick SC AUID- ORCID: 0000-0002-0906-3097 AD - Department of Cognitive Science, University of California, Irvine, Irvine, CA, United States. LA - eng GR - K08 HD107161/HD/NICHD NIH HHS/United States PT - Clinical Trial Protocol PT - Journal Article DEP - 20261006 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Cognition/physiology MH - *Depression/psychology/epidemiology MH - Ecological Momentary Assessment MH - Longitudinal Studies MH - *Sleep/physiology MH - Observational Studies as Topic PMC - PMC13641314 OTO - NOTNLM OT - cognition OT - depression OT - development OT - mobile health OT - remote research OT - sleep OT - wearable technology COIS- Conflicts of Interest: None declared. EDAT- 2026/10/06 17:31 MHDA- 2026/10/06 17:32 PMCR- 2026/10/06 CRDT- 2026/10/06 15:04 PHST- 2025/10/22 00:00 [received] PHST- 2026/08/04 00:00 [revised] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/10/06 17:32 [medline] PHST- 2026/10/06 17:31 [pubmed] PHST- 2026/10/06 15:04 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - v15i1e86345 [pii] AID - 86345 [pii] AID - 10.2196/86345 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Oct 6;15:e86345. doi: 10.2196/86345. PMID- 42837391 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261008 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 10 DP - 2026 TI - Gameful experience, exercise identity, and exercise adherence among Chinese university students: A moderated chain mediation model. PG - e0353100 LID - 10.1371/journal.pone.0353100 [doi] LID - e0353100 AB - BACKGROUND: Gamified fitness applications have grown in popularity, yet it remains unclear how gameful experience, defined as users' subjective perception of game-like engagement during app-supported exercise, is associated with exercise adherence. METHODS: A cross-sectional survey was conducted among N = 300 Chinese university students who were active users of gamified fitness applications. Data were collected via an online questionnaire platform (Questionnaire Star) from March 5 to April 5, 2026. Participants completed validated measures of gameful experience (GAMEX), exercise identity (EI), exercise habit formation (EHF), intolerance of uncertainty (IU), and exercise adherence (EA). A moderated chain mediation model was tested using hierarchical regression analysis and bias-corrected bootstrap resampling (5,000 iterations). An indirect effect was considered statistically different from zero when its 95% confidence interval excluded zero. RESULTS: Gameful experience was positively associated with exercise adherence ([Formula: see text] = .264, p < .001). The observed associations were consistent with three indirect pathways: GAMEX [Formula: see text] EI [Formula: see text] EA (effect = .065, 95% CI [.020, .114]); GAMEX [Formula: see text] EHF [Formula: see text] EA (effect = .043, 95% CI [.002, .087]); and GAMEX [Formula: see text] EI [Formula: see text] EHF [Formula: see text] EA (effect = .085, 95% CI [.054, .123]). IU moderated the GAMEX-EI association ([Formula: see text] = .237, p < .001, [Formula: see text] = .036); the estimated chain indirect effect ranged from .034 (95% CI [.001, .072]) at low IU to .136 (95% CI [.080, .201]) at high IU. These estimates describe conditional associations and do not establish causal or temporal ordering. CONCLUSIONS: The findings are consistent with the hypothesized ordering of gameful experience, exercise identity, exercise habit formation, and adherence, while alternative causal orderings remain possible. The moderation result suggests that IU may be a useful boundary condition to examine in longitudinal and experimental studies of identity-supportive app features. CI - Copyright: (c) 2026 Song et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Song, Jingjing AU - Song J AUID- ORCID: 0009-0007-3088-8900 AD - College of Physical Education and Health Management, Chongqing University of Education, Chongqing, China. FAU - Li, Jiaying AU - Li J AD - School of Physical Education, Chongqing University of Posts and Telecommunications, Chongqing, China. FAU - Li, Dan AU - Li D AD - School of Physical Education, Wuhan University of Science and Technology, Wuhan, Hubei, China. LA - eng PT - Journal Article DEP - 20261006 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - *Exercise/psychology MH - *Students/psychology MH - Male MH - Universities MH - Young Adult MH - Cross-Sectional Studies MH - China MH - Surveys and Questionnaires MH - *Video Games/psychology MH - Adult MH - Adolescent PMC - PMC13641342 COIS- The authors have declared that no competing interests exist. EDAT- 2026/10/06 17:31 MHDA- 2026/10/06 17:32 PMCR- 2026/10/06 CRDT- 2026/10/06 13:45 PHST- 2026/06/18 00:00 [received] PHST- 2026/09/14 00:00 [accepted] PHST- 2026/10/06 17:32 [medline] PHST- 2026/10/06 17:31 [pubmed] PHST- 2026/10/06 13:45 [entrez] PHST- 2026/10/06 00:00 [pmc-release] AID - PONE-D-26-28180 [pii] AID - 10.1371/journal.pone.0353100 [doi] PST - epublish SO - PLoS One. 2026 Oct 6;21(10):e0353100. doi: 10.1371/journal.pone.0353100. eCollection 2026. PMID- 42837008 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 11 DP - 2026 Oct 6 TI - Evaluation of subclinical organ involvement with ultrasound elastography in childhood familial Mediterranean fever: relationships with disease activity, inflammatory markers, colchicine response, and genotype. LID - 806 [pii] LID - 10.1007/s00431-026-07408-1 [doi] AB - This study evaluates multiorgan shear-wave elastography (SWE) in children with familial Mediterranean fever (FMF) during attack-free periods and examines associations with clinical and inflammatory parameters. In this single-center, retrospective cross-sectional case-control study, SWE measurements of the liver, spleen, bilateral kidneys, pancreas, four mesenteric fat regions, and bilateral thyroid lobes were evaluated in 75 children with FMF and 52 matched healthy controls. Adjusted linear regression, generalized estimating equation (GEE), and Benjamini-Hochberg correction were applied. The cohort included 127 children; age, sex, weight, height, and BMI were comparable between groups. After adjustment for age, sex, and BMI, FMF patients showed higher SWE values at all 11 sites: liver (beta = 3.25 kPa; 95% CI, 2.55-3.95), right kidney (beta = 0.94 kPa; 95% CI, 0.31-1.57), left kidney (beta = 1.15 kPa; 95% CI, 0.57-1.74), spleen (beta = 1.24 kPa; 95% CI, 0.55-1.93), pancreas (beta = 0.88 kPa; 95% CI, 0.21-1.55), mesenteric fat regions (beta range, 1.43-2.06 kPa), right thyroid lobe (beta = 1.62 kPa; 95% CI, 0.73-2.51), and left thyroid lobe (beta = 2.94 kPa; 95% CI, 2.05-3.83). Repeated-measures GEE showed an overall adjusted FMF-control difference of 1.71 kPa and a significant group x organ-site interaction. Exploratory analyses showed no FDR-significant associations with disease duration, diagnostic delay, ISSF score, attack-free CRP/ESR, colchicine responsiveness, or M694V/M694V genotype. CONCLUSION: Children with FMF had higher multiorgan and mesenteric fat SWE-derived stiffness during attack-free periods. Multiorgan SWE may help evaluate subclinical tissue-level changes in pediatric FMF, but the cross-sectional design, lack of histopathologic validation, and exploratory subgroup analyses preclude causal or therapeutic conclusions. WHAT IS KNOWN: * Familial Mediterranean fever may be associated with persistent subclinical inflammation during attack-free periods. * Shear-wave elastography can noninvasively quantify tissue stiffness. WHAT IS NEW: * Children with FMF showed higher liver, spleen, kidney, pancreas, thyroid, and mesenteric fat stiffness than controls. * These differences persisted after adjustment for age, sex, and BMI. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Uslu, Hande AU - Uslu H AD - Department of Radiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. hande.uslu@kocaeli.edu.tr. FAU - Tosun, Mesude AU - Tosun M AD - Department of Radiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. FAU - Sahin, Nihal AU - Sahin N AD - Department of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. FAU - Ozaslan, Nebahat Zeynep AU - Ozaslan NZ AD - Department of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. FAU - Oksel, Betul AU - Oksel B AD - Department of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. FAU - Aydin, Duygu AU - Aydin D AD - Department of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. FAU - Apaydin, Hulusi Ferhat AU - Apaydin HF AD - Department of Radiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. FAU - Altin, Ece Devrim AU - Altin ED AD - Department of Radiology, Sakarya Yenikent State Hospital, Sakarya, Turkey. FAU - Sonmez, Hafize Emine AU - Sonmez HE AD - Department of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey. LA - eng PT - Journal Article DEP - 20261006 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - SML2Y3J35T (Colchicine) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Familial Mediterranean Fever/drug therapy/diagnostic imaging/genetics MH - Female MH - Male MH - Child MH - *Elasticity Imaging Techniques/methods MH - Cross-Sectional Studies MH - Retrospective Studies MH - Case-Control Studies MH - *Colchicine/therapeutic use MH - Adolescent MH - Genotype MH - Pancreas/diagnostic imaging MH - Child, Preschool MH - Biomarkers/blood MH - Liver/diagnostic imaging MH - Spleen/diagnostic imaging MH - Kidney/diagnostic imaging MH - Thyroid Gland/diagnostic imaging OTO - NOTNLM OT - Colchicine resistance OT - Familial Mediterranean fever OT - Multiorgan ultrasonography OT - Pediatric OT - Shear-wave elastography COIS- Declarations. Ethics approval: The study protocol was approved by the Local Research Ethics Committee (Approval No. 2026/137) and was conducted in accordance with the principles of the Declaration of Helsinki. Informed consent: The requirement for written informed consent was waived by the Local Research Ethics Committee. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/06 17:31 MHDA- 2026/10/06 17:32 CRDT- 2026/10/06 11:16 PHST- 2026/06/23 00:00 [received] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/08/27 00:00 [revised] PHST- 2026/10/06 17:32 [medline] PHST- 2026/10/06 17:31 [pubmed] PHST- 2026/10/06 11:16 [entrez] AID - 10.1007/s00431-026-07408-1 [pii] AID - 10.1007/s00431-026-07408-1 [doi] PST - epublish SO - Eur J Pediatr. 2026 Oct 6;185(11):806. doi: 10.1007/s00431-026-07408-1. PMID- 42836182 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261007 IS - 1177-8881 (Electronic) IS - 1177-8881 (Linking) VI - 20 DP - 2026 TI - Optimal Dosing Strategies for Remimazolam Across Diverse Patient Populations: A Clinical Narrative Review. PG - 644446 LID - 10.2147/DDDT.S644446 [doi] LID - 644446 AB - Remimazolam is an ultra-short-acting benzodiazepine that is hydrolyzed by carboxylesterase 1 (CES1) to the inactive metabolite CNS 7054. Since regulatory approval in 2020 it has been adopted globally for procedural sedation and general anesthesia, supported by an expanding evidence base of randomized trials, population pharmacokinetic/pharmacodynamic (PK/PD) modeling studies, dose-finding sequential-allocation analyses, and meta-analyses. Synthesizing 92 studies published between January 2020 and April 2026, this narrative review defines dose optimization across diverse populations. For adult procedural sedation, a fixed 5 mg initial bolus followed by 2.5 mg maintenance titrations achieves moderate sedation with a hemodynamic and respiratory profile that compares favorably with propofol, whereas general anesthesia requires an induction rate of 6 to 12 mg kg(-1) h(-1) followed by maintenance at 1.0-2.0 mg kg(-1) h(-1). Dosing demands a 25-30% reduction in the elderly (>/= 65 years), higher weight-adjusted requirements in pediatric patients (1-18 years), and lean or corrected body weight scalars in obesity, while severe hepatic impairment reduces clearance by approximately 38% and opioid co-administration yields a 15-63% synergistic reduction in effective concentrations. Several quantitative estimates, however, derive from single-center trials with fewer than 30 participants per arm that have not been externally validated. To help clinicians weigh these recommendations, each population-level dosing estimate is graded by the strength and external validity of its supporting evidence (A, B, or C); most special-population point estimates rest on single-center studies (grade C) and are best regarded as starting points rather than established standards. Crucially, the halted Japanese Phase II intensive care unit trial (ONO-2745-04) serves as a key safety counter-narrative: continuous infusions exceeding 24 hours in critically ill patients may be associated with drug accumulation and delayed emergence, suggesting that organ-independent clearance may not be guaranteed when CES1 activity is compromised. Major evidence gaps persist for infants under one year of age, long-duration anesthesia, CES1 polymorphisms, and non-East-Asian populations. CI - (c) 2026 Illias et al. FAU - Illias, Amina M AU - Illias AM AUID- ORCID: 0009-0002-9430-3776 AD - Department of Anesthesiology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. AD - College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Tsai, Yung-Fong AU - Tsai YF AUID- ORCID: 0000-0002-3121-4840 AD - Department of Anesthesiology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan. AD - College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Wu, Shao-Chun AU - Wu SC AUID- ORCID: 0000-0002-0984-6921 AD - College of Medicine, Chang Gung University, Taoyuan, Taiwan. AD - Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. LA - eng PT - Journal Article PT - Review DEP - 20261001 PL - New Zealand TA - Drug Des Devel Ther JT - Drug design, development and therapy JID - 101475745 RN - 7V4A8U16MB (remimazolam) RN - 12794-10-4 (Benzodiazepines) RN - 0 (Hypnotics and Sedatives) SB - IM MH - Humans MH - *Benzodiazepines/administration & dosage/pharmacokinetics MH - *Hypnotics and Sedatives/administration & dosage/pharmacokinetics MH - Dose-Response Relationship, Drug PMC - PMC13637680 OAB - Remimazolam is a fast-acting sedative that anesthesiologists now use worldwide for short procedures and for general anesthesia. The body breaks it down rapidly with an enzyme called carboxylesterase 1, which is found mainly in liver cells but works independently of the slower liver pathways and the kidneys that clear most other sedatives, so doctors expected the dose to be easy to predict. In practice, the recommended dose still varies widely between different types of patients, and it has been hard for clinicians to know which numbers to trust. We searched the published research up to April 2026 and brought together 92 studies. We compared the doses used in adults, older people, children, people carrying extra weight, and people whose liver or kidneys do not work well. We also graded how strong the evidence behind each recommendation is. We found that older patients need roughly a quarter to a third less drug, children need more per kilogram of body weight, and much less drug is needed when a strong painkiller is given at the same time. We also found that the drug can build up and delay waking when it is given for more than a day to patients who are seriously ill, so its usual advantage over other sedatives may not apply to them. Many of the published dose figures come from single hospitals and small groups of patients, so clinicians should treat them as sensible starting points and adjust the dose for each patient rather than follow them as fixed rules. OABL- eng OTO - NOTNLM OT - dosing OT - pharmacodynamics OT - population pharmacokinetics OT - procedural sedation OT - remimazolam OT - special populations COIS- The authors report no conflicts of interest in this work. EDAT- 2026/10/06 11:31 MHDA- 2026/10/06 11:32 PMCR- 2026/10/01 CRDT- 2026/10/06 07:28 PHST- 2026/07/30 00:00 [received] PHST- 2026/09/22 00:00 [accepted] PHST- 2026/10/06 11:32 [medline] PHST- 2026/10/06 11:31 [pubmed] PHST- 2026/10/06 07:28 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - 644446 [pii] AID - 10.2147/DDDT.S644446 [doi] PST - epublish SO - Drug Des Devel Ther. 2026 Oct 1;20:644446. doi: 10.2147/DDDT.S644446. eCollection 2026. PMID- 42836153 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261006 LR - 20261007 IS - 1680-5348 (Electronic) IS - 1020-4989 (Print) IS - 1020-4989 (Linking) VI - 50 DP - 2026 TI - Body weight perception and body self-esteem in adolescents with overweight or obesity in Costa Rica: challenges for public health policy. PG - e80 LID - 10.26633/RPSP.2026.80 [doi] LID - e80 AB - OBJECTIVE: This study estimates the prevalence of weight misperception among Costa Rican adolescents in general and examines its association with body esteem and weight-control behaviors to inform public health policy. METHODS: The authors analyzed cross-sectional data collected in 2017 from a probabilistic sample of 818 adolescents aged 13-18 years enrolled in public and private secondary schools in urban and rural areas of the province of San Jose, Costa Rica. Weight and height were measured by trained nutritionists and classified using World Health Organization body mass index (BMI)-for-age standards. Perceived weight status was assessed using culturally appropriate response categories adapted from the Youth Risk Behavior Survey and refined through a pilot study. Body esteem and weight-control behaviors were measured using validated survey instruments. RESULTS: Among adolescents with overweight or obesity, 59% underestimated their weight, most commonly perceiving themselves as having an "adequate weight." Weight underestimation was associated with higher body esteem and lower engagement in weight-control behaviors after adjustment for key sociodemographic characteristics. CONCLUSION: By contributing evidence from a Latin American context-where research on adolescent weight perception remains scarce-this study enhances understanding of how excess weight is perceived during adolescence in settings where overweight is highly prevalent and supports public policy approaches that prioritize healthy eating and active living from adolescence. FAU - Monge-Rojas, Rafael AU - Monge-Rojas R AD - Nutrition and Health Unit Costa Rican Institute for Research and Education on Nutrition and Health (INCIENSA) Ministry of Health Tres Rios 4-2250 Costa Rica Nutrition and Health Unit, Costa Rican Institute for Research and Education on Nutrition and Health (INCIENSA), Ministry of Health, Tres Rios 4-2250, Costa Rica. FAU - Smith-Castro, Vanessa AU - Smith-Castro V AD - Psychological Research Institute University of Costa Rica City of Research Montes de Oca 11501-2060 Costa Rica Psychological Research Institute, University of Costa Rica, City of Research, Montes de Oca 11501-2060, Costa Rica. FAU - Vargas-Quesada, Rulaman AU - Vargas-Quesada R AD - Nutrition and Health Unit Costa Rican Institute for Research and Education on Nutrition and Health (INCIENSA) Ministry of Health Tres Rios 4-2250 Costa Rica Nutrition and Health Unit, Costa Rican Institute for Research and Education on Nutrition and Health (INCIENSA), Ministry of Health, Tres Rios 4-2250, Costa Rica. LA - eng PT - Journal Article DEP - 20261005 PL - United States TA - Rev Panam Salud Publica JT - Revista panamericana de salud publica = Pan American journal of public health JID - 9705400 PMC - PMC13637699 OTO - NOTNLM OT - Adolescent OT - Latin America OT - body weight OT - obesity OT - overweight OT - weight perception COIS- Conflicts of interests. None declared. EDAT- 2026/10/06 11:31 MHDA- 2026/10/06 11:32 PMCR- 2026/10/05 CRDT- 2026/10/06 07:24 PHST- 2026/02/10 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/10/06 11:32 [medline] PHST- 2026/10/06 11:31 [pubmed] PHST- 2026/10/06 07:24 [entrez] PHST- 2026/10/05 00:00 [pmc-release] AID - RPSP.2026.80 [pii] AID - 10.26633/RPSP.2026.80 [doi] PST - epublish SO - Rev Panam Salud Publica. 2026 Oct 5;50:e80. doi: 10.26633/RPSP.2026.80. eCollection 2026. PMID- 42835958 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261006 LR - 20261007 IS - 2772-4875 (Electronic) IS - 2772-4875 (Linking) VI - 31 DP - 2026 Dec TI - Early-onset atherosclerotic cardiovascular disease in young adults: Lifestyle, environmental, and psychosocial risk factors. PG - 200714 LID - 10.1016/j.ijcrp.2026.200714 [doi] LID - 200714 AB - Early-onset atherosclerotic cardiovascular disease (ASCVD) must be distinguished from cardiovascular risk factors and subclinical vascular abnormalities that may arise at younger ages. This narrative review critically examines lifestyle, environmental, metabolic, psychosocial, and inherited determinants among adolescents (10-19 years), young adults (20-39 years), and selected adults aged 40-54 years who remain within commonly used thresholds for premature events. The 40-54-year band is included selectively to bridge younger-adult prevention with guideline-based adult risk assessment and is not intended to redefine the upper age limit of premature ASCVD. Epidemiological evidence demonstrates a substantial burden of cardiovascular disease (CVD) among people aged 15-39 years; however, evidence of increasing clinically manifest ASCVD is less consistent than evidence of rising obesity, hypertension, dyslipidemia, diabetes, nicotine exposure, and subclinical vascular injury. Established causal drivers, including cumulative exposure to apolipoprotein B-containing lipoproteins and cigarette smoking, are distinguished from predominantly associative evidence concerning sleep disruption, psychosocial stress, e-cigarette use, and air pollution. Prevention should combine population-level health promotion with age-appropriate clinical risk assessment, including lipid screening and measurement of lipoprotein(a) at least once in adulthood, with additional targeted evaluation for familial hypercholesterolemia, a family history of premature ASCVD, obesity, hypertension, diabetes, chronic kidney disease, and smoking or vaping. Coronary artery calcium scoring and carotid imaging are not recommended as universal screening tests for asymptomatic young people, although they may refine clinical decisions in carefully selected adults. Digital tools may support engagement but should complement, rather than replace, validated clinical care and public-health measures. CI - (c) 2026 The Authors. FAU - Khasanovna, Tukhtaeva Nigora AU - Khasanovna TN AD - "Propaedeutics of Internal Diseases No. 2", Tashkent State Medical University, Tashkent, Uzbekistan. FAU - Egamberdi Son, Babajanov Xudoybergan AU - Egamberdi Son BX AD - Tashkent State Medical University, Tashkent, Uzbekistan. LA - eng PT - Journal Article PT - Review DEP - 20260924 PL - Netherlands TA - Int J Cardiol Cardiovasc Risk Prev JT - International journal of cardiology. Cardiovascular risk and prevention JID - 9918282077306676 PMC - PMC13636304 OTO - NOTNLM OT - Atherosclerotic cardiovascular disease OT - Familial hypercholesterolemia OT - Premature cardiovascular disease OT - Prevention OT - Risk assessment OT - Young adults OT - lipoprotein(a) EDAT- 2026/10/06 11:31 MHDA- 2026/10/06 11:32 PMCR- 2026/09/24 CRDT- 2026/10/06 07:06 PHST- 2026/05/13 00:00 [received] PHST- 2026/09/18 00:00 [revised] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/10/06 11:32 [medline] PHST- 2026/10/06 11:31 [pubmed] PHST- 2026/10/06 07:06 [entrez] PHST- 2026/09/24 00:00 [pmc-release] AID - S2772-4875(26)00144-3 [pii] AID - 200714 [pii] AID - 10.1016/j.ijcrp.2026.200714 [doi] PST - epublish SO - Int J Cardiol Cardiovasc Risk Prev. 2026 Sep 24;31:200714. doi: 10.1016/j.ijcrp.2026.200714. eCollection 2026 Dec. PMID- 42835802 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261006 LR - 20261007 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Mediterranean diet, eating behaviours, and nutritional intervention in childhood obesity: what works, where, and for whom-a narrative review. PG - 1892494 LID - 10.3389/fnut.2026.1892494 [doi] LID - 1892494 AB - Childhood obesity is a leading public health challenge with rising global prevalence and significant impacts on cardiometabolic health extending into adulthood. Lifestyle intervention, with nutrition as its central component, is the main point of paediatric obesity management, yet the evidence base remains fragmented across regions, instruments, and clinical models. This narrative review synthesises European evidence on Mediterranean diet (MD) adherence assessment, multidisciplinary intervention outcomes, and global comparative patterns in paediatric obesity management. Among dietary patterns, the Mediterranean diet (MD) remains the most evidence-supported framework for cardiometabolic prevention in children and adolescents. KIDMED, a 16-item validated instrument, has been adapted for multiple European paediatric populations and consistently identifies low legume, whole grain, and extra-virgin olive oil intake as the principal adherence gaps associated with a higher body mass index (BMI) Z-score, as well as a higher age- and sex-specific BMI percentile. The Children's Eating Behaviour Questionnaire (CEBQ) provides a complementary behavioural marker with food-approach subscales positively associated with BMI Z-score and food-avoidance subscales inversely associated, a pattern replicated across European, Latin American, and Middle Eastern cohorts. Structured multidisciplinary interventions consistently produce modest reductions in BMI Z-score, typically between 0.10 and 0.25 units over 3 to 12 months. The strongest predictors of response are younger age, lower baseline obesity severity, breakfast adherence, and the absence of obese parents. Low KIDMED score additionally functions as a screening signal for paediatric Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD). Continental comparisons suggest that dietary-quality predictors of paediatric obesity are broadly consistent across regions. However, the feasibility of Mediterranean-style approaches varies substantially with local food availability, culinary traditions and economic access, so cross-cultural application of KIDMED-based screening requires careful local adaptation. The review concludes that routine integration of KIDMED and CEBQ within structured multidisciplinary pathways represents an evidence-informed, implementation-ready step for pediatric obesity care, particularly in under-studied Central and Eastern Europe. CI - Copyright (c) 2026 Bober and Gaszynska. FAU - Bober, Julia AU - Bober J AD - International Doctoral School, Medical University of Lodz, Lodz, Poland. AD - Department of Nutrition and Epidemiology, Medical University of Lodz, Lodz, Poland. FAU - Gaszynska, Ewelina AU - Gaszynska E AD - Department of Nutrition and Epidemiology, Medical University of Lodz, Lodz, Poland. LA - eng PT - Journal Article PT - Review DEP - 20260921 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13635886 OTO - NOTNLM OT - CEBQ OT - KIDMED OT - Mediterranean diet OT - childhood obesity OT - lifestyle intervention COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/06 11:31 MHDA- 2026/10/06 11:32 PMCR- 2026/09/21 CRDT- 2026/10/06 06:52 PHST- 2026/05/27 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/06 11:32 [medline] PHST- 2026/10/06 11:31 [pubmed] PHST- 2026/10/06 06:52 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - 10.3389/fnut.2026.1892494 [doi] PST - epublish SO - Front Nutr. 2026 Sep 21;13:1892494. doi: 10.3389/fnut.2026.1892494. eCollection 2026. PMID- 42835418 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261006 LR - 20261007 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Feasibility of FnNO measurement in preschoolers and development of predictive models. PG - 1891740 LID - 10.3389/fped.2026.1891740 [doi] LID - 1891740 AB - BACKGROUND: Fractional nasal exhaled nitric oxide (FnNO) is a valuable biomarker of upper airway mucosal inflammation, but its clinical application in preschoolers is limited by uncertain compliance and a lack of reference data. This study aimed to evaluate the feasibility of standardized FnNO measurement in children aged 3-6 years, identify independent predictors of test cooperation and first-attempt success to build exploratory predictive models, and provide preliminary distribution estimates of FnNO in healthy preschoolers. METHODS: A total of 148 preschoolers aged 3-6 years were enrolled. Test completion and first-attempt success rates were recorded. Multivariable logistic regression was used to identify independent predictors of compliance. Exploratory predictive models were developed and evaluated using receiver operating characteristic (ROC) analysis with internal bootstrap validation. FnNO distribution characteristics were analyzed in both the general cohort and a healthy subgroup. RESULTS: The overall test completion rate was 82.4% (122/148), and the first-attempt success rate was 76.2% (77/101). Multivariable analysis demonstrated that female sex (OR = 4.853, P = 0.004) and greater height (OR = 1.216, P = 0.000) were independent predictors of test completion. Age was the sole independent predictor of first-attempt success (OR = 2.299, P = 0.001). The predictive model for test completion (sex and height) achieved an area under the curve (AUC) of 0.870, while the first-attempt success model (age and BMI) yielded an AUC of 0.749. The median FnNO level was 315.50 ppb (IQR: 168.00-410.00 ppb) across the overall cohort and 324.00 ppb (IQR: 221.00-378.50 ppb) in the healthy subgroup (n = 81). CONCLUSIONS: Standardized FnNO measurement is feasible in preschool children. Height, sex, and age are key factors influencing test cooperation. The proposed predictive models offer exploratory statistical tools for population stratification in research contexts, though prospective clinical validation remains necessary. This study establishes preliminary reference estimates for FnNO in Chinese preschoolers. CI - (c) 2026 Wang, Lin, Wang and Li. FAU - Wang, Yue AU - Wang Y AD - Department of Pediatric Respiratory Medicine, Children's Medical Center, The First Hospital of Jilin University, Changchun, Jilin, China. FAU - Lin, Qianqian AU - Lin Q AD - Department of Pediatric Respiratory Medicine, Children's Medical Center, The First Hospital of Jilin University, Changchun, Jilin, China. FAU - Wang, Haoyu AU - Wang H AD - Department of Pediatric Respiratory Medicine, Children's Medical Center, The First Hospital of Jilin University, Changchun, Jilin, China. FAU - Li, Yanchun AU - Li Y AD - Department of Pediatric Respiratory Medicine, Children's Medical Center, The First Hospital of Jilin University, Changchun, Jilin, China. LA - eng PT - Journal Article DEP - 20260921 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13635358 OTO - NOTNLM OT - FnNO OT - children OT - compliance OT - feasibility OT - predictive model COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/06 11:31 MHDA- 2026/10/06 11:32 PMCR- 2026/09/21 CRDT- 2026/10/06 06:14 PHST- 2026/05/26 00:00 [received] PHST- 2026/09/07 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/06 11:32 [medline] PHST- 2026/10/06 11:31 [pubmed] PHST- 2026/10/06 06:14 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - 10.3389/fped.2026.1891740 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 21;14:1891740. doi: 10.3389/fped.2026.1891740. eCollection 2026. PMID- 42835024 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261006 LR - 20261007 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Diet quality in pediatric migraine and the educational quality of related short-form videos: a cross-sectional study and content analysis. PG - 1934926 LID - 10.3389/fnut.2026.1934926 [doi] LID - 1934926 AB - BACKGROUND: Diet quality has been associated with headache burden and psychosocial outcomes in children with migraine, while caregivers increasingly use short-form videos for dietary and lifestyle advice. However, evidence on overall diet quality and related video quality remains limited. METHODS: This study included 180 children aged 7-18 years with migraine. Diet quality was assessed using the Chinese Children Dietary Index (CCDI). Participants were divided at the median CCDI score of 117.7 into low- and high-CCDI groups (n = 90 each). Between-group comparisons included Pediatric Migraine Disability Assessment (PedMIDAS) scores, headache characteristics, analgesic use, caregiver burden, and anxiety and depressive symptoms. Multivariable regression was used to examine adjusted associations between CCDI scores and clinical outcomes. Caregiver use of short-form videos was also surveyed. In addition, 150 videos on dietary and lifestyle management of pediatric migraine from Douyin, Kuaishou, and Xiaohongshu were analyzed for educational quality, reliability, and actionability. RESULTS: The high-CCDI group had lower PedMIDAS scores than the low-CCDI group (29.54 +/- 17.20 vs. 41.96 +/- 14.72), fewer headache days over 28 days [6.00 (4.00, 8.00) vs. 9.00 (8.00, 11.00)], lower pain intensity, and fewer days of analgesic use (all p < 0.001). Caregiver burden and anxiety and depression scores were also lower (all p < 0.05). After adjustment, higher CCDI scores remained associated with lower PedMIDAS scores, fewer headache days, lower pain intensity, fewer days of analgesic use, and lower caregiver burden. Diet and lifestyle management was the most frequently searched topic (30.6%), yet only 34.4% of caregivers fully verified video recommendations with a physician. Although 90.0% of videos provided recommendations concordant with clinical guidelines or evidence-based recommendations, reliability, actionability, and nutrition follow-up remained limited; nutrition follow-up was addressed in only 23.33% of videos. CONCLUSION: Higher overall diet quality was associated with lower migraine burden and caregiver burden in children with migraine. These findings support the relevance of overall dietary assessment, while prospective studies are needed to clarify temporal and causal relationships. Short-form videos are an important source of dietary and lifestyle information for caregivers, but their reliability, actionability, and follow-up content require improvement. CI - Copyright (c) 2026 Li, Liu, Jiang, Xu, Zhou and Xu. FAU - Li, Haisu AU - Li H AD - Department of Anesthesiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China. FAU - Liu, Lan AU - Liu L AD - Department of Anesthesiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China. FAU - Jiang, Jiayi AU - Jiang J AD - Department of Anesthesiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China. FAU - Xu, Yumei AU - Xu Y AD - Department of Anesthesiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China. FAU - Zhou, Dan AU - Zhou D AD - Department of Anesthesiology, The Affiliated Dazu's Hospital of Chongqing Medical University, Chongqing, China. FAU - Xu, Ying AU - Xu Y AD - Department of Anesthesiology Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China. LA - eng PT - Journal Article DEP - 20260921 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13634853 OTO - NOTNLM OT - Chinese Children Dietary Index OT - diet quality OT - dietary management OT - pediatric migraine OT - short-form videos COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/06 11:31 MHDA- 2026/10/06 11:32 PMCR- 2026/09/21 CRDT- 2026/10/06 05:17 PHST- 2026/07/11 00:00 [received] PHST- 2026/08/14 00:00 [revised] PHST- 2026/09/01 00:00 [accepted] PHST- 2026/10/06 11:32 [medline] PHST- 2026/10/06 11:31 [pubmed] PHST- 2026/10/06 05:17 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - 10.3389/fnut.2026.1934926 [doi] PST - epublish SO - Front Nutr. 2026 Sep 21;13:1934926. doi: 10.3389/fnut.2026.1934926. eCollection 2026. PMID- 42833415 OWN - NLM STAT- Publisher LR - 20261010 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 76 DP - 2026 Oct 5 TI - Anthropometric profile, severity, and concordance of MUAC and BMI-for-age classification among clinically screened pediatric patients at a tertiary care hospital in south Rajasthan: A hospital-based cross-sectional study. PG - 105167 LID - S2405-4577(26)02264-3 [pii] LID - 10.1016/j.clnesp.2026.105167 [doi] AB - INTRODUCTION: Undernutrition remains a leading contributor to childhood morbidity and mortality in India, and southern Rajasthan - with a large rural and tribal catchment - carries a disproportionate burden. Data describing the anthropometric profile of malnourished children who actually reach tertiary care in this region are limited. AIM: To characterise the anthropometric profile and severity of malnutrition among children undergoing clinical screening at a tertiary care hospital in South Rajasthan, to classify nutritional status using age- and sex-specific WHO z-scores, to assess agreement between mid-upper arm circumference (MUAC) and BMI-for-age classification, and to examine associations between anthropometric, dietary, demographic and behavioural variables. MATERIALS AND METHODS: A hospital-based cross-sectional study was conducted in the Department of Pediatrics of a tertiary care teaching hospital in Udaipur, Rajasthan, over four months of data collection. One hundred and twenty-five children aged 6 months to 18 years, identified as malnourished on clinical screening, were enrolled by consecutive sampling. Weight, height, body mass index (BMI) and mid-upper arm circumference (MUAC) were measured by standard technique; habitual pre-illness dietary energy and protein intake were obtained by recall and compared with age-appropriate recommended allowances. Non-parametric tests, Chi-square, Spearman correlation and Cohen's kappa were used, with P < 0.05 considered significant. RESULTS: Of 125 children undergoing clinical screening (mean age 3.37 +/- 3.02 years; 59.2% male; 76.0% rural), age- and sex-specific WHO BMI-for-age z-scores (WHO Child Growth Standards for 6-60 months; WHO Growth Reference 2007 for 61-228 months) classified 31 (24.8%) as wasted and 78 (62.4%) as severely wasted, together 87.2%; 16 (12.8%) were normal. Mean BMI was 12.05 +/- 1.45 kg/m(2) and mean MUAC 12.77 +/- 2.23 cm. In the subgroup aged 6-59 months for whom WHO MUAC cut-offs are validated (n = 102), MUAC classified 31 (30.4%) as severe and 24 (23.5%) as moderate acute malnutrition; among the 91 children in this subgroup classified as wasted or severely wasted by BMI-for-age z-score, 42 (46.2%) had a MUAC value in the normal range. Agreement between MUAC and z-score-based BMI classification in this subgroup was negligible (linear-weighted kappa = 0.02; unweighted kappa = 0.03). Percentage calorie deficit correlated inversely with MUAC (rho = -0.608, P < 0.001), an association that persisted after adjusting for age (partial rho = -0.583, P < 0.001), but not with BMI. No demographic factor reached significance; age group approached it (P = 0.051). CONCLUSION: Among children undergoing clinical screening at this tertiary care centre in South Rajasthan, malnutrition was severe and predominantly acute on z-score-based BMI-for-age classification. Fixed MUAC cut-offs performed poorly outside the 6-59 month band for which they are validated, and a substantial proportion of children with acute malnutrition on BMI-for-age were not flagged by MUAC. These findings support the consideration of complementary anthropometric assessment - using MUAC alongside BMI/weight-for-height and age- and sex-specific WHO z-scores rather than raw cut-offs - particularly in primary and referral care settings serving a wide paediatric age range. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Kumar, Dinesh AU - Kumar D AD - Department of Pharmacology, Pacific College of Pharmacy, Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, 313001, India. Electronic address: 2016dineshkr@gmail.com. FAU - Singh, Anukrman AU - Singh A AD - Department of Pharmacology, Pacific College of Pharmacy, Pacific Academy of Higher Education and Research University, Udaipur, Rajasthan, 313001, India. FAU - More, S S AU - More SS AD - Department of Pediatrics, Pacific Medical College and Hospital, Udaipur, Rajasthan, 313001, India. LA - eng PT - Journal Article DEP - 20261005 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM OTO - NOTNLM OT - Anthropometry OT - Child nutrition disorders OT - Cross-sectional studies OT - Mid-upper arm circumference OT - Rajasthan OT - Wasting syndrome COIS- Conflicts of interest There are no conflicts of interest. EDAT- 2026/10/05 23:30 MHDA- 2026/10/05 23:30 CRDT- 2026/10/05 19:32 PHST- 2026/08/07 00:00 [received] PHST- 2026/09/24 00:00 [revised] PHST- 2026/09/30 00:00 [accepted] PHST- 2026/10/05 23:30 [pubmed] PHST- 2026/10/05 23:30 [medline] PHST- 2026/10/05 19:32 [entrez] AID - S2405-4577(26)02264-3 [pii] AID - 10.1016/j.clnesp.2026.105167 [doi] PST - aheadofprint SO - Clin Nutr ESPEN. 2026 Oct 5;76:105167. doi: 10.1016/j.clnesp.2026.105167. PMID- 42833305 OWN - NLM STAT- Publisher LR - 20261005 IS - 2589-5559 (Electronic) IS - 2589-5559 (Linking) DP - 2026 Oct 5 TI - Sex differences in MASLD and fitness improvement during a weight loss intervention for adolescents living with obesity. PG - 102059 LID - S2589-5559(26)00330-7 [pii] LID - 10.1016/j.jhepr.2026.102059 [doi] AB - BACKGROUND AND AIMS: The interplay between liver and muscle health is incompletely understood, especially in adolescents living with obesity. Cardiopulmonary exercise testing (CPET) evaluates cardiorespiratory fitness through peak oxygen uptake ( O(2)peak). The association of baseline cardiorespiratory fitness and metabolic dysfunction-associated steatotic liver disease (MASLD), and their longitudinal co-evolution during a lifestyle intervention, have not been studied in this population. METHODS: Adolescents with obesity receiving a lifestyle intervention in a residential setting were prospectively followed for 9 - 12 months. At baseline and after 6 months, MASLD was defined as a controlled-attenuation parameter >/= 248dB/m. Cardiorespiratory fitness and body composition were assessed at the start and throughout the trajectory. RESULTS: 142 adolescents (69 boys) were included. Relative O(2)peak was 37.9 (33.5 - 42.3) vs. 43.4 (39.7 - 49.8 ; p=0.004) mL∙kg(-1)∙min(-1) [LM] in boys with and without MASLD, and respectively 36.3 (31.7 - 43.2) vs. 41.3 (34.8 - 46.2 ; p=0.055) mL∙kg(-1)∙min(-1) [LM] in girls. Oxygen uptake efficiency slope (OUES) was respectively 40.6 (35.8 - 46.3) vs. 46.7 (41.6 - 53.8; p=0.011) in boys and 39.1 (34.7 - 45.1) vs. 44.2 (39.1 - 50.8 ; p=0.011) in girls. For boys with MASLD, initial relative O(2)peak was the lowest for those with persistent MASLD during the lifestyle trajectory (33.5; 30.5 - 36.6 mL∙kg(-1)∙min(-1) [LM]). During the lifestyle intervention, lean body mass (LM) was preserved in boys with MASLD resolution and girls without baseline MASLD, whereas boys with persistent MASLD and girls with baseline MASLD experienced LM losses of 7 - 9%. CONCLUSION: Lower baseline cardiorespiratory fitness, independent from (fat) mass, is associated with (persistent) MASLD during a residential lifestyle intervention. LM preservation during weight loss trajectories, with concomitant improvement of maximal oxygen uptake, are important therapeutic targets. IMPACT AND IMPLICATIONS: Metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common liver disease in children and adolescents worldwide. Although a better cardiorespiratory fitness at the start of a lifestyle intervention is linked with more weight loss, its association with cardiometabolic health and MASLD has not been assessed. A lower initial cardiorespiratory fitness was observed in adolescents with (persistent) MASLD, and in boys with an increased transient elastography. During the lifestyle intervention, boys and girls without MASLD or boys who experience MASLD resolution preserve their lean mass. Improvement of cardiorespiratory fitness and preservation of lean mass during a structured lifestyle intervention are important therapeutic targets, and sex-specific lifestyle interventions need to be developed and validated. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Buytaert, Maarten AU - Buytaert M AD - Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Liver Research Center Ghent, Ghent University Hospital, Ghent, Belgium. FAU - Vandekerckhove, Kristof AU - Vandekerckhove K AD - Department of Pediatric Cardiology, Ghent University Hospital, Ghent, Belgium. FAU - Coomans, Ilse AU - Coomans I AD - Department of Pediatric Cardiology, Ghent University Hospital, Ghent, Belgium. FAU - Vangampelaere, Maxine AU - Vangampelaere M AD - Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Liver Research Center Ghent, Ghent University Hospital, Ghent, Belgium. FAU - Dupont, Ellen AU - Dupont E AD - Medical Department, Zeepreventorium, De Haan, Belgium. FAU - Stalpaert, Silke AU - Stalpaert S AD - Medical Department, Zeepreventorium, De Haan, Belgium. FAU - Caen, Kevin AU - Caen K AD - Department of Movement and Sports Sciences, Ghent University, Ghent, Belgium. FAU - Lefere, Sander AU - Lefere S AD - Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Liver Research Center Ghent, Ghent University Hospital, Ghent, Belgium. FAU - De Bruyne, Ruth AU - De Bruyne R AD - Hepatology Research Unit, Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium; Liver Research Center Ghent, Ghent University Hospital, Ghent, Belgium; Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ghent University Hospital, Ghent, Belgium. Electronic address: ruth.debruyne@uzgent.be. LA - eng PT - Journal Article DEP - 20261005 PL - Netherlands TA - JHEP Rep JT - JHEP reports : innovation in hepatology JID - 101761237 SB - IM OTO - NOTNLM OT - cardiorespiratory fitness OT - lifestyle intervention OT - muscle-liver axis OT - pediatric MASLD OT - pediatric obesity EDAT- 2026/10/05 23:30 MHDA- 2026/10/05 23:30 CRDT- 2026/10/05 19:29 PHST- 2026/03/18 00:00 [received] PHST- 2026/09/24 00:00 [revised] PHST- 2026/09/27 00:00 [accepted] PHST- 2026/10/05 23:30 [medline] PHST- 2026/10/05 23:30 [pubmed] PHST- 2026/10/05 19:29 [entrez] AID - S2589-5559(26)00330-7 [pii] AID - 10.1016/j.jhepr.2026.102059 [doi] PST - aheadofprint SO - JHEP Rep. 2026 Oct 5:102059. doi: 10.1016/j.jhepr.2026.102059. PMID- 42832767 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261005 LR - 20261007 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 9 DP - 2026 Oct 5 TI - Online Lifestyle Support for Adolescents Undergoing Metabolic and Bariatric Surgery: Pilot Prospective Cohort Study. PG - e86816 LID - 10.2196/86816 [doi] LID - e86816 AB - BACKGROUND: Metabolic and bariatric surgery (MBS) is a safe and effective treatment for adolescents with severe obesity, yet no standardized lifestyle interventions exist to support sustained behavior change after MBS. OBJECTIVE: This pilot study assessed the feasibility and acceptability of TeenLyft, an online lifestyle support program for adolescents undergoing MBS, and explored preliminary clinical and safety outcomes to inform the design of a future randomized trial. METHODS: Adolescents aged 13 to 18 years were recruited from a tertiary care MBS center and enrolled in TeenLyft. The study was not powered or designed as a randomized controlled trial but rather as a pilot to guide future randomized controlled trial development. Feasibility domains included recruitment, retention, data completeness, intervention fidelity, and engagement, with predefined progression criteria of >/=80% enrollment, >/=70% retention, >/=70% data completeness, and >/=90% fidelity. Exploratory clinical and safety measures (weight, BMI, and cardiometabolic markers) were collected descriptively to confirm that participation was not associated with harm. RESULTS: Twenty-nine adolescents (mean age 15.9 years, SD 1.1; n=22, 75.9% female; n=13, 44.8% Hispanic; mean BMI 47.8, SD 7.3 kg/m(2)) were enrolled, representing 145% of the recruitment target (n=20), with 72.4% retention at 6 months. All feasibility progression criteria were met. Descriptive trends showed expected post-MBS reductions in weight and BMI and improvements in blood pressure and hemoglobin A(1c), with no adverse cardiometabolic effects observed. CONCLUSIONS: TeenLyft demonstrated high feasibility, acceptability, and safety as an adjunct to adolescent MBS care. Findings support progression to a fully powered randomized trial to evaluate long-term effectiveness and sustainability. CI - (c) Sarah E Messiah, Jackson M Francis, Folefac D Atem, Matthew Sunil Mathew, Alicia Wheelington, Maral Misserian, Sitapriya Neti, Rashon Braxton, Bethany R Cartwright, Faisal G Qureshi, Sarah E Barlow, Marlyn A Alicock. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org). FAU - Messiah, Sarah E AU - Messiah SE AUID- ORCID: 0000-0001-6685-2175 AD - Peter O'Donnell Jr. School of Public Health, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX, 75390, United States, 1 3057785309. AD - Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States. AD - Child and Adolescent Population Health Program, Children's Health System of Texas, Dallas, TX, United States. AD - Children's Health System of Texas, Dallas, TX, United States. FAU - Francis, Jackson M AU - Francis JM AUID- ORCID: 0009-0003-3840-8431 AD - Child and Adolescent Population Health Program, Children's Health System of Texas, Dallas, TX, United States. FAU - Atem, Folefac D AU - Atem FD AUID- ORCID: 0000-0002-1142-7806 AD - University of Texas Health Science Center at Houston (UTHealth) School of Public Health, Dallas, TX, United States. FAU - Mathew, Matthew Sunil AU - Mathew MS AUID- ORCID: 0000-0002-7529-2832 AD - Child and Adolescent Population Health Program, Children's Health System of Texas, Dallas, TX, United States. FAU - Wheelington, Alicia AU - Wheelington A AUID- ORCID: 0000-0003-1739-8759 AD - Children's Health System of Texas, Dallas, TX, United States. AD - Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, United States. FAU - Misserian, Maral AU - Misserian M AUID- ORCID: 0000-0001-8369-5132 AD - School of Allied Health Professions, University of Texas Southwestern Medical Center, Dallas, TX, United States. FAU - Neti, Sitapriya AU - Neti S AUID- ORCID: 0000-0003-4445-3258 AD - Child and Adolescent Population Health Program, Children's Health System of Texas, Dallas, TX, United States. FAU - Braxton, Rashon AU - Braxton R AUID- ORCID: 0009-0006-8397-1532 AD - University of Texas Health Science Center at Houston (UTHealth) School of Public Health, Dallas, TX, United States. FAU - Cartwright, Bethany R AU - Cartwright BR AUID- ORCID: 0000-0002-1013-9298 AD - Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States. AD - Touchstone Diabetes Center, University of Texas Southwestern Medical Center, Dallas, TX, United States. FAU - Qureshi, Faisal G AU - Qureshi FG AUID- ORCID: 0000-0002-7986-720X AD - Children's Health System of Texas, Dallas, TX, United States. AD - Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, United States. FAU - Barlow, Sarah E AU - Barlow SE AUID- ORCID: 0000-0002-1672-2126 AD - Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, United States. AD - Children's Health System of Texas, Dallas, TX, United States. FAU - Alicock, Marlyn A AU - Alicock MA AUID- ORCID: 0000-0002-2114-6768 AD - University of Texas Health Science Center at Houston (UTHealth) School of Public Health, Dallas, TX, United States. LA - eng GR - R21 HD105129/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20261005 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC13638075 OTO - NOTNLM OT - adolescents OT - cardiometabolic OT - lifestyle intervention OT - metabolic and bariatric surgery OT - weight loss COIS- Conflicts of Interest: FGQ is a consultant at Ethicon Industries. All other authors declare no conflicts of interest. EDAT- 2026/10/05 17:31 MHDA- 2026/10/05 17:32 PMCR- 2026/10/05 CRDT- 2026/10/05 16:33 PHST- 2025/10/31 00:00 [received] PHST- 2026/06/14 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/10/05 17:32 [medline] PHST- 2026/10/05 17:31 [pubmed] PHST- 2026/10/05 16:33 [entrez] PHST- 2026/10/05 00:00 [pmc-release] AID - v9i1e86816 [pii] AID - 86816 [pii] AID - 10.2196/86816 [doi] PST - epublish SO - JMIR Pediatr Parent. 2026 Oct 5;9:e86816. doi: 10.2196/86816. PMID- 42830479 OWN - NLM STAT- MEDLINE DCOM- 20261005 LR - 20261005 IS - 1523-5378 (Electronic) IS - 1083-4389 (Linking) VI - 31 IP - 5 DP - 2026 Sep-Oct TI - Epidemiology of Helicobacter pylori and Gastric Atrophy in Rural Southwestern Uganda: The ENIGMA Uganda Study. PG - e70163 LID - 10.1111/hel.70163 [doi] AB - BACKGROUND: Characterizing the epidemiology of Helicobacter pylori (H. pylori) infection and gastric atrophy (GA) is essential for informing preventive strategies in anticipation of the rising gastric cancer burden. The International Agency for Research on Cancer has initiated global studies to characterize these epidemiological patterns using a standardized framework, including in Uganda. MATERIALS AND METHODS: This population-based study included 700 individuals aged 1-69 years, randomly selected from the General Population Cohort in rural Uganda, stratified by sex and age. Participants completed a structured questionnaire to assess risk factors related to H. pylori infection and GA, underwent anthropometric measurements, and provided blood samples. Anti-H. pylori IgG antibodies were measured using enzyme-linked immunosorbent assays (ELISA). In individuals aged >/= 40 years, plasma pepsinogen I (PG I) and pepsinogen II (PG II) concentrations were measured by ELISA to define gastric atrophy. RESULTS: The age-standardized H. pylori seroprevalence was 76%. The crude seroprevalence was 63% in children aged 1-9 years, rose to over 80% in individuals aged 10-39 years, and then declined modestly in older age groups (73% in individuals aged >/= 40). Men aged >/= 40 years had a lower H. pylori seroprevalence compared to women aged >/= 40 years (68% vs. 78%, p < 0.05). Serologically defined GA was uncommon, with an overall prevalence of 6% (17/301; 95% CI: 3%-9%) among individuals aged >/= 40 years. Obesity (aOR 6.0, 95% CI 1.6-20.9) and less than daily chili consumption (aOR 4.3, 95% CI 1.4-14.9) were associated with higher odds of GA among participants aged >/= 40 years, after adjustment for age and sex. CONCLUSIONS: In this population-based study in rural southwestern Uganda, H. pylori infection was acquired early in life and was highly prevalent, whereas serologically defined gastric atrophy remained relatively uncommon. This distinct epidemiological pattern warrants further validation and investigation. CI - (c) 2026 John Wiley & Sons Ltd. The WHO International Agency for Research on Cancer retains copyright and all other rights in the manuscript of this article as submitted for publication. FAU - Huang, Yue AU - Huang Y AUID- ORCID: 0000-0002-0864-8990 AD - Early Detection, Prevention and Infections Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France. FAU - Knaze, Viktoria AU - Knaze V AUID- ORCID: 0000-0002-9646-2052 AD - Early Detection, Prevention and Infections Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France. FAU - Mugisha, Joseph AU - Mugisha J AD - Uganda Research Unit, MRC/UVRI and LSHTM, Entebbe, Uganda. FAU - Navionis, Anne-Sophie AU - Navionis AS AUID- ORCID: 0009-0002-9854-1114 AD - Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France. FAU - Rinaldi, Sabina AU - Rinaldi S AUID- ORCID: 0000-0002-6846-1204 AD - Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France. FAU - Clifford, Gary M AU - Clifford GM AUID- ORCID: 0000-0001-7534-333X AD - Early Detection, Prevention and Infections Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France. FAU - Park, Jin Young AU - Park JY AUID- ORCID: 0000-0003-2491-5099 AD - Early Detection, Prevention and Infections Branch, International Agency for Research on Cancer (IARC/WHO), Lyon, France. FAU - Newton, Robert AU - Newton R AD - Uganda Research Unit, MRC/UVRI and LSHTM, Entebbe, Uganda. AD - University of York, York, UK. LA - eng GR - Centre International de Recherche sur le Cancer/ PT - Journal Article PL - England TA - Helicobacter JT - Helicobacter JID - 9605411 RN - 0 (Antibodies, Bacterial) RN - 9001-10-9 (Pepsinogen A) SB - IM MH - Humans MH - Uganda/epidemiology MH - *Helicobacter Infections/epidemiology/complications MH - Female MH - Male MH - Adult MH - Middle Aged MH - Adolescent MH - Child MH - Child, Preschool MH - *Helicobacter pylori/isolation & purification/immunology MH - Aged MH - Young Adult MH - Infant MH - Rural Population MH - Seroepidemiologic Studies MH - Antibodies, Bacterial/blood MH - *Gastritis, Atrophic/epidemiology MH - Pepsinogen A/blood MH - Risk Factors MH - Prevalence MH - Enzyme-Linked Immunosorbent Assay OTO - NOTNLM OT - Helicobacter pylori OT - gastric atrophy OT - pepsinogen OT - prevalence EDAT- 2026/10/05 05:31 MHDA- 2026/10/05 05:32 CRDT- 2026/10/05 00:33 PHST- 2026/08/12 00:00 [revised] PHST- 2026/06/16 00:00 [received] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/05 05:32 [medline] PHST- 2026/10/05 05:31 [pubmed] PHST- 2026/10/05 00:33 [entrez] AID - 10.1111/hel.70163 [doi] PST - ppublish SO - Helicobacter. 2026 Sep-Oct;31(5):e70163. doi: 10.1111/hel.70163. PMID- 42830421 OWN - NLM STAT- Publisher LR - 20261004 IS - 1547-6510 (Electronic) IS - 1040-8347 (Linking) DP - 2026 Oct 4 TI - Analytical Strategies for Trace-Level Determination of Hormones in Infant Milk Formula: Advances, Challenges, and Future Perspectives. PG - 1-21 LID - 10.1080/10408347.2026.2736080 [doi] AB - Infant milk formula (IMF) is designed to support infants during a highly sensitive stage of development, yet its trace-level bioactive composition remains less explored than its nutritional profile. Among these minor constituents, hormones are of particular interest because they link infant nutrition with endocrine regulation, food safety, and analytical chemistry. Hormones in IMF may originate naturally from milk-derived ingredients, result from veterinary practices, or occur as hormone-like endocrine-active residues. However, their determination is challenging due to their low concentrations and the complexity of the formula matrix, which can interfere with extraction, clean-up, separation, and detection. This review critically summarizes recent advances in analytical strategies for trace-level hormone determination in IMF, focusing on sample preparation, chromatographic and mass spectrometric techniques, method validation, analytical challenges, and future perspectives. It also critically evaluates the reported analytical strategies from a White Analytical Chemistry perspective, emphasizing the balance between analytical performance, environmental sustainability, robustness, cost-effectiveness, and routine applicability. Despite progress in extraction, purification, and sensitive detection approaches, gaps remain in occurrence data, method harmonization, validation consistency, and exposure assessment. To the best of our knowledge, this is the first review dedicated specifically to hormones analysis in IMF. FAU - S El-Tahlawy, Ahmed AU - S El-Tahlawy A AUID- ORCID: 0000-0002-4506-0168 AD - Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand. FAU - Alahmad, Waleed AU - Alahmad W AUID- ORCID: 0000-0003-1379-8755 AD - Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand. LA - eng PT - Journal Article PT - Review DEP - 20261004 PL - United States TA - Crit Rev Anal Chem JT - Critical reviews in analytical chemistry JID - 9004784 SB - IM OTO - NOTNLM OT - Analytical methods OT - hormones OT - infant formula OT - sample preparation EDAT- 2026/10/05 05:31 MHDA- 2026/10/05 05:31 CRDT- 2026/10/04 23:59 PHST- 2026/10/05 05:31 [medline] PHST- 2026/10/05 05:31 [pubmed] PHST- 2026/10/04 23:59 [entrez] AID - 10.1080/10408347.2026.2736080 [doi] PST - aheadofprint SO - Crit Rev Anal Chem. 2026 Oct 4:1-21. doi: 10.1080/10408347.2026.2736080. PMID- 42830064 OWN - NLM STAT- MEDLINE DCOM- 20261004 LR - 20261004 IS - 1512-0112 (Print) IS - 1512-0112 (Linking) IP - 376-377 DP - 2026 Jul-Aug TI - ACE I/D AND NOS3 G894T POLYMORPHISMS AND CARDIOVASCULAR ADAPTATION PROFILES IN ADOLESCENT FOOTBALL PLAYERS. PG - 281-288 AB - AIM: To assess the associations of ACE I/D (rs4646994) and NOS3 G894T (rs1799983) polymorphisms with cardiovascular adaptation profiles, autonomic regulation, exercise tolerance and responsiveness to individualized training-load correction in adolescent football players. MATERIALS AND METHODS: This controlled comparative study with an observational pre-post follow-up component included 228 male adolescents aged 13-17 years: 168 football players with at least two years of regular training and 60 non-athlete peers. The examination included anthropometry, body composition assessment, resting and exercise electrocardiography, echocardiography, short-term heart rate variability (HRV) analysis, submaximal bicycle ergometry with PWC170 and estimated VO2max, heart-rate recovery (HRR), and genotyping of ACE I/D and NOS3 G894T polymorphisms. The 3-month individualized training-load correction was analyzed as a non-randomized observational component; therefore, its results were interpreted as post-correction dynamics rather than as definitive evidence of causal efficacy. RESULTS: Football players had a lower resting heart rate than controls (58.6+/-6.8 vs 72.4+/-7.5 beats/min; p<0.001), higher PWC170 (196+/-32.6 vs 142+/-28.4 W; p<0.001), higher relative PWC170 (3.42+/-0.52 vs 2.40+/-0.46 W/kg; p<0.001), higher estimated VO2max (54.0+/-4.8 vs 42.5+/-5.2 ml/kg/min; p<0.001) and faster HRR1 (43.6+/-11.3 vs 25.3+/-10.4 beats/min; p<0.001). ACE and NOS3 genotype distributions were comparable between football players and controls. Within the athletic cohort, ACE DD and, to a lesser extent, NOS3 T-allele carriage were associated with lower SDNN, RMSSD and pNN50, higher LF/HF and less favorable diastolic indices. After three months of individualized training-load correction, positive HRV and diastolic dynamics were observed mainly in favorable and intermediate genetic profiles, whereas the unfavorable profile showed limited changes. CONCLUSION: ACE I/D and NOS3 G894T polymorphisms should not be interpreted as markers of football participation or selection. They may be considered exploratory modifiers of autonomic reserve, diastolic adaptation and response to individualized training-load monitoring. Integration of genotyping with ECG, echocardiography, HRV, HRR and PWC170 appears promising for personalized monitoring in adolescent football players but requires further external validation. The results of the dynamic stage should be interpreted as observational, since the training-load correction was not randomized. FAU - Ruziyeva, A AU - Ruziyeva A AD - 1Department of Medical Rehabilitation, Sports Medicine and Traditional Medicine of the Samarkand State Medical University, Uzbekistan. FAU - Khamidov, O AU - Khamidov O AD - 2Rehabilitology and Sports Medicine Research Institute of the Samarkand State Medical University, Uzbekistan. FAU - Murodqosimov, S AU - Murodqosimov S AD - 3Department of Biology, Samarkand State Pedagogical Institute, Uzbekistan. FAU - Doniyorov, B AU - Doniyorov B AD - 4Faculty of Medicine, Abdulla Qodiriy Jizzakh State Pedagogical University, Uzbekistan. FAU - Khalimova, F AU - Khalimova F AD - 5Department of Normal and Pathological Physiology, Medical-Social Institute of Tajikistan, Dushanbe, Tajikistan. FAU - Marwan, I AU - Marwan I AD - 6Department of Medical Laboratory Sciences, College of Health Sciences, Gulf Medical University, Ajman, United Arab Emirates. LA - eng PT - Journal Article PL - Georgia (Republic) TA - Georgian Med News JT - Georgian medical news JID - 101218222 RN - EC 3.4.15.1 (Peptidyl-Dipeptidase A) RN - EC 1.14.13.39 (Nitric Oxide Synthase Type III) RN - EC 1.14.13.39 (NOS3 protein, human) RN - EC 3.4.15.1 (ACE protein, human) SB - IM MH - Humans MH - Adolescent MH - Male MH - *Peptidyl-Dipeptidase A/genetics MH - *Nitric Oxide Synthase Type III/genetics MH - Heart Rate/genetics/physiology MH - *Adaptation, Physiological/genetics MH - Polymorphism, Single Nucleotide MH - Athletes MH - Exercise Tolerance/genetics MH - Soccer MH - Genotype MH - Polymorphism, Genetic EDAT- 2026/10/04 23:29 MHDA- 2026/10/04 23:30 CRDT- 2026/10/04 18:43 PHST- 2026/10/04 23:30 [medline] PHST- 2026/10/04 23:29 [pubmed] PHST- 2026/10/04 18:43 [entrez] PST - ppublish SO - Georgian Med News. 2026 Jul-Aug;(376-377):281-288. PMID- 42829788 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261004 LR - 20261005 IS - 2277-9531 (Print) IS - 2319-6440 (Electronic) IS - 2277-9531 (Linking) VI - 15 DP - 2026 TI - Design and implementation of a pediatric failure to thrive registry system in Iran. PG - 366 LID - 10.4103/jehp.jehp_852_25 [doi] LID - 366 AB - BACKGROUND: Failure to thrive (FTT) refers to inadequate growth caused by an inability to acquire or use enough calories for growth. It refers to a failure to develop over time, which can lead to more serious problems in adulthood if left untreated. FTT is a significant global health concern, particularly in developing countries like Iran. Effective FTT management necessitates timely, inclusive, and precise data on children's FTT status. A pediatric FTT registry system is a useful tool for gathering and managing data on children with FTT. This study proposes a pediatric FTT registry system for Iran. MATERIALS AND METHODS: A developmental-applied study was conducted in three phases during 2024. The first phase involved defining the features of a pediatric FTT registry system through interviews with experts. The second phase entailed expert validation using the Delphi method. In the third phase, the software was designed based on a conceptual model using the Hypertext Preprocessor programming language and the Laravel framework. PostgreSQL was employed as the database management system. Moreover, Nielsen's Ten Usability Heuristics was used to evaluate the software's usability from the users' perspectives. RESULTS: Experts validated the features of the pediatric FTT registry system, resulting in a framework that included eight headings, 24 sub-headings, and 117 data elements. The usability assessment of the software revealed that the highest number of issues concerned the "error prevention" indicator, whereas the "aesthetic and minimalist design" indicator presented the fewest problems and was assumed flawless. CONCLUSION: A pediatric FFT registry system contributes significantly to service planning, management, disease surveillance, and research. Accordingly, future research is recommended to investigate the feasibility of implementing the pediatric FFT registry system in Iran. CI - Copyright: (c) 2026 Journal of Education and Health Promotion. FAU - Khademi, Sahar AU - Khademi S AD - Department of Health Information Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran. FAU - Langarizadeh, Mostafa AU - Langarizadeh M AD - Department of Health Information Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran. FAU - Sheikhtaheri, Abbas AU - Sheikhtaheri A AD - Health Management and Economics Research Center, Health Management Research Institute, Iran University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article DEP - 20260831 PL - India TA - J Educ Health Promot JT - Journal of education and health promotion JID - 101593794 PMC - PMC13633805 OTO - NOTNLM OT - Failure to thrive OT - failure to thrive registry OT - low weight OT - registry OT - registry system OT - stunting COIS- There are no conflicts of interest. EDAT- 2026/10/04 05:36 MHDA- 2026/10/04 05:37 PMCR- 2026/08/31 CRDT- 2026/10/04 04:15 PHST- 2025/05/08 00:00 [received] PHST- 2025/07/29 00:00 [accepted] PHST- 2026/10/04 05:37 [medline] PHST- 2026/10/04 05:36 [pubmed] PHST- 2026/10/04 04:15 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - JEHP-15-366 [pii] AID - 10.4103/jehp.jehp_852_25 [doi] PST - epublish SO - J Educ Health Promot. 2026 Aug 31;15:366. doi: 10.4103/jehp.jehp_852_25. eCollection 2026. PMID- 42829327 OWN - NLM STAT- Publisher LR - 20261003 IS - 1751-8431 (Electronic) IS - 1751-8423 (Linking) DP - 2026 Oct 3 TI - Clinical Relevance of the Eating and Drinking Ability Classification System in Young Children with Cerebral Palsy: Associations with Child and Family Outcomes Relevant to Rehabilitation. PG - 1-9 LID - 10.1080/17518423.2026.2738684 [doi] AB - BACKGROUND: The Eating and Drinking Ability Classification System (EDACS) is a validated functional classification system for assessing feeding ability in individuals with cerebral palsy (CP). Its clinical relevance in relation to broader child and family outcomes has received limited attention, particularly in young children. This study evaluated associations between EDACS and motor function, communication ability, nutritional status, behavioral profile and caregiver quality of life in young children with CP. METHODS: This cross-sectional study included 100 children aged 18-60 months with CP attending a tertiary Child Development Center in North India. Of these, 49 (49%) were aged 18-35 months and 51 (51%) were aged 36-60 months; 49 (49%) were classified as GMFCS Levels IV-V. Feeding ability was classified using age-appropriate EDACS descriptors. Gross motor function and communication were assessed using GMFCS and CFCS, respectively. Nutritional status was assessed using weight-for-length/height Z scores, mid-upper arm circumference and clinical pallor. Behavioral problems and caregiver quality of life were evaluated using the Child Behavior Checklist and WHOQOL-BREF, respectively. Associations were assessed using Kruskal-Wallis and Fisher's exact tests, Spearman's rank correlation, cumulative ordinal logistic regression and linear regression. RESULTS: Increasing EDACS level was associated with poorer nutritional status, including lower weight-for-length/height Z scores, reduced mid-upper arm circumference and higher prevalence of clinical pallor (all p /= 25 kg/m(2) recruited from central Arkansas. The participants will be randomized to a standard of care group receiving standardized lactation support (N = 60); a prenatal intervention group receiving standardized lactation support + antenatal breast milk expression (ABME) between 37 weeks of gestation until birth (N = 60); or a postnatal intervention group receiving standardized lactation support + dietary meal plan designed to align with the Dietary Guidelines for Americans from 2 weeks to 6 months postpartum (N = 60). Study assessments will include repeated measures of maternal and infant anthropometrics, body composition, dietary intake, and archiving of biospecimens (blood, human milk, stool, and urine) during infancy and until 6 months postpartum. The primary outcomes are breastfeeding outcomes (initiation, duration, exclusivity) and human milk composition (macronutrients, energy, and bioactive components). Questionnaires will assess maternal demographics and socioeconomic status, breastfeeding self-efficacy, maternal depression, stress, and quality of life as well as infant feeding intention, and medical lactation history. DISCUSSION: This randomized control trial will generate novel evidence on the safety, feasibility, and effectiveness of ABME and provision of a healthy postnatal meal plan in a population at elevated risk for breastfeeding challenges. By evaluating clinical and nutritional strategies, this study will advance the understanding of how maternal behavior and physiology influence breastfeeding outcomes, human milk composition and early life programming of infant growth and development. Findings will also address critical gaps identified by the Dietary Guidelines Advisory Committee by guiding nutritional recommendations for women with excess weight. The results will inform future strategies targeting short and long-term maternal-infant health outcomes. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/study/NCT00616395, identifier NCT00616395. CI - Copyright (c) 2026 da Cruz, Fiecke, Fuenmayor, Beckett, Morris, Kay, Massey-Swindle, Sobik and Andres. FAU - da Cruz, Larissa Leandro AU - da Cruz LL AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Fiecke, Chelsey AU - Fiecke C AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Fuenmayor, Anni AU - Fuenmayor A AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. FAU - Beckett, Emily AU - Beckett E AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. AD - Arkansas Children's Hospital, Southwest Little Rock Community Clinic, Little Rock, AR, United States. FAU - Morris, Andrew AU - Morris A AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. AD - Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Kay, Colin D AU - Kay CD AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Massey-Swindle, Taren AU - Massey-Swindle T AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Sobik, Sarah AU - Sobik S AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Andres, Aline AU - Andres A AD - Arkansas Children's Nutrition Center, Little Rock, AR, United States. AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. LA - eng SI - ClinicalTrials.gov/NCT00616395 PT - Journal Article DEP - 20260918 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13630693 OTO - NOTNLM OT - antenatal breastmilk expression OT - breastfeeding OT - colostrum OT - dietary intervention OT - human milk OT - lactation support OT - obesity OT - pregnancy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/04 00:33 MHDA- 2026/10/04 00:34 PMCR- 2026/09/18 CRDT- 2026/10/03 05:50 PHST- 2026/04/13 00:00 [received] PHST- 2026/08/12 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/04 00:34 [medline] PHST- 2026/10/04 00:33 [pubmed] PHST- 2026/10/03 05:50 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.3389/fnut.2026.1854997 [doi] PST - epublish SO - Front Nutr. 2026 Sep 18;13:1854997. doi: 10.3389/fnut.2026.1854997. eCollection 2026. PMID- 42827757 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261003 LR - 20261005 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Fifteen-minute recess freestyle rope skipping enhances classroom attention in junior high school students in the context of healthy school development: mechanisms and implications. PG - 1906224 LID - 10.3389/fpsyg.2026.1906224 [doi] LID - 1906224 AB - In the context of healthy school development and the policy mandating 15-min recess physical activity for middle school students, this study employed a longitudinal quasi-experimental design to investigate the effects of 15-min recess freestyle rope skipping on middle school students' classroom attention and emotional indicators. Based on grade level and activity format (individual practice vs. group cooperation), a total of 160 students, 80 boys and 80 girls, aged 13.9 to 14.5 years, from grades 8 and 9 at a middle school in Shijiazhuang were selected and divided into four groups. A 16-week intervention involving individual vs. group freestyle rope skipping for 15 min per session was conducted. Students' recess immediate emotions, classroom academic emotions, and classroom attention were measured using validated self-report scales, specifically the Exercise-Induced Mood Scale, the Classroom Academic Emotion Scale, and the Classroom Attention Scale, at three time points (pre-intervention, mid-intervention, and post-intervention). Data were analyzed using repeated-measures ANOVA, correlation analysis, and mediation analysis. The results indicated that classroom attention significantly increased from 65.54 (pre-intervention) to 74.68 (post-intervention) across all groups. Classroom academic emotions and recess immediate emotions also exhibited significant changes over time, with significant time x group interaction effects, suggesting that the trajectories of change differed by grade level and activity format. Correlation analysis revealed that improvements in recess immediate emotions and classroom academic emotions were significantly positively correlated with increases in classroom attention, with the strongest correlation found between classroom academic emotions and classroom attention changes (r = 0.450, p < 0.001). Mediation analysis showed that classroom academic emotions significantly mediated the relationship between activity format and changes in classroom attention (indirect effect = 3.098, 95% CI [1.179, 5.525]), whereas the chain mediation pathway (recess immediate emotions --> classroom academic emotions --> classroom attention) was not significant. This study provides evidence that 15-min recess freestyle rope skipping is associated with improvements in middle school students' classroom attention and improve their emotional states, with the intervention effects moderated by grade level and activity format. This study provides empirical evidence for the fields of physical activity, emotion, and attention, and offers practical guidance for optimizing recess physical activities and promoting healthy school development in secondary schools. CI - Copyright (c) 2026 Li, Chen, Cen and Liu. FAU - Li, Jianmin AU - Li J AD - College of Physical Education, Hefei University of Technology, Hefei, China. FAU - Chen, Xiaoting AU - Chen X AD - College of Physical Education, Yangzhou University, Yangzhou, China. FAU - Cen, Wei AU - Cen W AD - College of Physical Education, Yangzhou University, Yangzhou, China. FAU - Liu, Chao AU - Liu C AD - College of Physical Education, Yangzhou University, Yangzhou, China. LA - eng PT - Journal Article DEP - 20260918 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13630699 OTO - NOTNLM OT - 15-min recess OT - classroom academic emotions OT - classroom attention OT - freestyle rope skipping OT - healthy school development COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/04 00:33 MHDA- 2026/10/04 00:34 PMCR- 2026/09/18 CRDT- 2026/10/03 05:49 PHST- 2026/06/11 00:00 [received] PHST- 2026/08/16 00:00 [revised] PHST- 2026/08/30 00:00 [accepted] PHST- 2026/10/04 00:34 [medline] PHST- 2026/10/04 00:33 [pubmed] PHST- 2026/10/03 05:49 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1906224 [doi] PST - epublish SO - Front Psychol. 2026 Sep 18;17:1906224. doi: 10.3389/fpsyg.2026.1906224. eCollection 2026. PMID- 42827730 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261003 LR - 20261005 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Predicting multiple mental health outcomes in adolescents using explainable machine learning models. PG - 1923390 LID - 10.3389/fpsyt.2026.1923390 [doi] LID - 1923390 AB - INTRODUCTION: Adolescent mental health problems, including depression, anxiety, and stress, are an increasing public health concern, yet the factors associated with different mental health outcomes may vary across domains. This study investigated shared and outcome-specific predictive features of depression, anxiety, perceived stress, and psychological well-being using explainable machine learning models. METHODS: A cross-sectional study was conducted among 1,088 adolescents aged 13-18 years recruited from secondary schools in Wuhan, China, using multistage cluster sampling. Participants completed validated measures of emotional dysregulation, loneliness, social media addiction, self-esteem, sleep quality, academic stress, family support, physical activity, and mental health outcomes. Four algorithms-linear regression, support vector regression, Random Forest, and XGBoost-were trained using an 80/20 train-test split with five-fold cross-validation, and model performance was evaluated using test-set R(2), RMSE, and MAE. SHapley Additive exPlanations (SHAP) were used to examine feature contributions. To minimize target leakage, outcome-specific feature sets were used, with PSQI and RSES excluded from the depression model because of direct or substantial conceptual overlap with PHQ-9 content, and PSQI excluded from the well-being model because of overlap with WHO-5 content. RESULTS: XGBoost showed the strongest out-of-sample predictive performance across all four outcomes, explaining 49% of the variance in depression (R(2) = 0.49, 95% CI: 0.44-0.53; RMSE = 3.52; MAE = 2.81), 55% in anxiety (R(2) = 0.55, 95% CI: 0.50-0.59; RMSE = 3.04; MAE = 2.47), 60% in perceived stress (R(2) = 0.60, 95% CI: 0.56-0.64; RMSE = 3.71; MAE = 2.87), and 50% in psychological well-being (R(2) = 0.50, 95% CI: 0.45-0.54; RMSE = 3.38; MAE = 2.68). DISCUSSION: Emotional dysregulation and loneliness were consistently among the most influential features, while academic stress, family support, social media addiction, self-esteem, and sleep quality showed outcome-specific contributions. SHAP rankings for the depression model were stable across five-fold cross-validation, with emotional dysregulation and loneliness consistently occupying the highest ranks. CI - Copyright (c) 2026 Dong, Meng, Wang, Yan and Liu. FAU - Dong, Xiaojie AU - Dong X AD - Department of Psychiatry, Ward 1, Wuhan Mental Health Center, Wuhan, Hubei, China. FAU - Meng, Jing AU - Meng J AD - Department of Psychiatry, Ward 1, Wuhan Mental Health Center, Wuhan, Hubei, China. FAU - Wang, Peng AU - Wang P AD - Department of Psychiatry, Ward 1, Wuhan Mental Health Center, Wuhan, Hubei, China. FAU - Yan, Chuandong AU - Yan C AD - Department of Psychiatry, Ward 1, Wuhan Mental Health Center, Wuhan, Hubei, China. FAU - Liu, Xiaobo AU - Liu X AD - Department of Medical Administration, Wuhan Mental Health Center, Wuhan, Hubei, China. LA - eng PT - Journal Article DEP - 20260918 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13631644 OTO - NOTNLM OT - adolescent OT - emotional dysregulation OT - loneliness OT - machine learning OT - mental health OT - predictive modeling COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/04 00:33 MHDA- 2026/10/04 00:34 PMCR- 2026/09/18 CRDT- 2026/10/03 05:43 PHST- 2026/06/29 00:00 [received] PHST- 2026/08/22 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/10/04 00:34 [medline] PHST- 2026/10/04 00:33 [pubmed] PHST- 2026/10/03 05:43 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1923390 [doi] PST - epublish SO - Front Psychiatry. 2026 Sep 18;17:1923390. doi: 10.3389/fpsyt.2026.1923390. eCollection 2026. PMID- 42827615 OWN - NLM STAT- MEDLINE DCOM- 20261003 LR - 20261006 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - A novel method based on ultrasound radiomics for predicting attainment of near-adult height in adolescents. PG - 1925196 LID - 10.3389/fendo.2026.1925196 [doi] LID - 1925196 AB - OBJECTIVE: This study aimed to develop and validate a novel ultrasound radiomics model for predicting the attainment of near-adult height (NAH) in adolescents. METHODS: This dual-center prospective cohort study enrolled 192 adolescents aged 11.0-18.0 years. Standardized ultrasound examinations of the ulnar growth plate region were performed, and 475 radiomic features were extracted. Feature selection was conducted using Least Absolute Shrinkage and Selection Operator (LASSO) algorithm with 5-fold cross-validation. Seven machine learning algorithms were compared to develop predictive models. Three models were constructed: clinical (sex and bone age), radiomics (Rad-score), and combined (sex, bone age, and Rad-score). Model performance was evaluated using area under the receiver operating characteristic curve, accuracy, sensitivity, specificity, calibration curves, and decision curve analysis. RESULTS: Three stable radiomic features were selected with selection frequency >/=80%: wavelet-LH_glcm_Imc2, wavelet-LL_ngtdm_Busyness, and wavelet-HL_firstorder_Energy. The combined model demonstrated superior performance, achieving AUCs of 0.981 (95% CI: 0.948-1.000) in the validation set, with sensitivity of 90% and specificity of 100%. Multivariate analysis identified independent positive predictors including Rad-score (OR = 3.28, P = 0.013) and bone age (OR = 2.65, P < 0.001). And male sex was a significant negative predictor (OR = 0.15, P = 0.005). CONCLUSION: The combined ultrasound radiomics machine learning model achieved excellent predictive performance for NAH attainment in adolescents. The non-ionizing ultrasound approach enables repeated dynamic monitoring, and the derived nomogram facilitates individualized risk stratification in routine pediatric practice. CI - Copyright (c) 2026 Zhang, Zhao, Sun, Zhang, Yang, Pan, Chen, Li and Yang. FAU - Zhang, Yixuan AU - Zhang Y AD - Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Zhao, Zeqing AU - Zhao Z AD - Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Sun, Yuxin AU - Sun Y AD - Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Zhang, Li AU - Zhang L AD - Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Yang, Yamei AU - Yang Y AD - Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Pan, Hui AU - Pan H AD - Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Chen, Shi AU - Chen S AD - Key Laboratory of Endocrinology of National Health Commission, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Li, Jianchu AU - Li J AD - Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Yang, Xiao AU - Yang X AD - Department of Ultrasound, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. AD - Zhangzhou Municipal Hospital Affiliated to Fujian Medical University, Zhangzhou, Fujian, China. LA - eng PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20260918 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Body Height/physiology MH - *Growth Plate/diagnostic imaging MH - Machine Learning MH - Prospective Studies MH - *Radiomics MH - Ultrasonography/methods PMC - PMC13630604 OTO - NOTNLM OT - adolescent growth assessment OT - machine learning OT - near-adult height OT - predictive model OT - ultrasound radiomics COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/04 00:33 MHDA- 2026/10/04 00:34 PMCR- 2026/09/18 CRDT- 2026/10/03 05:29 PHST- 2026/07/01 00:00 [received] PHST- 2026/08/31 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/04 00:34 [medline] PHST- 2026/10/04 00:33 [pubmed] PHST- 2026/10/03 05:29 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.3389/fendo.2026.1925196 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 18;17:1925196. doi: 10.3389/fendo.2026.1925196. eCollection 2026. PMID- 42827605 OWN - NLM STAT- MEDLINE DCOM- 20261003 LR - 20261005 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Near-final adult height after GnRHa plus growth hormone in central precocious puberty: a single-center cohort study and predicted adult height validation audit. PG - 1885575 LID - 10.3389/fendo.2026.1885575 [doi] LID - 1885575 AB - BACKGROUND: Whether adjunctive recombinant human growth hormone (rhGH) improves near-final adult height (NFAH) during gonadotropin-releasing hormone analog (GnRHa) therapy for central precocious puberty (CPP) remains uncertain, and predicted adult height (PAH) may reflect treatment selection and prognosis. METHODS: We analyzed a single-center retrospective cohort of 235 children with CPP who initiated GnRHa between January 2018 and December 2020. The primary endpoint was chart-recorded NFAH in the female-only maturity-ascertained cohort (n = 91); the criterion-confirmed all-sex set included 94 patients. The primary adjusted model (M2) included treatment, baseline age, body mass index (BMI), IGF-1, BA-CA, and baseline height; baseline bone age was not entered separately because bone age = chronological age + BA-CA. Missing baseline covariates were handled using 20 imputations by chained equations. Height gain and change in height standard deviation score (SDS) from baseline to 24 months were secondary outcomes. Results: Mean NFAH was 160.17 cm with GnRHa alone and 161.87 cm with GnRHa + rhGH. The adjusted M2 association was +2.26 cm (95% CI 0.12 to 4.40); the chart-PAH-conditioned M3 estimate was +0.58 cm (-1.60 to 2.75) and was treated as diagnostic. At 24 months, M2 estimates were +3.23 cm (2.00 to 4.46) for height gain, +3.24 cm (2.03 to 4.46) in analysis of covariance (ANCOVA) of attained height, and +0.46 SDS (0.27 to 0.66). In the criterion-confirmed female bone-age cohort, M2 estimates were +0.00 years (-0.27 to 0.27) for bone age at 24 months and -0.14 years (-0.30 to 0.03) for bone-age progression. CONCLUSIONS: Adjunctive rhGH was associated with greater growth over 24 months and a positive, imprecisely estimated NFAH difference. Because this was an observational study, ascertainment criteria were heterogeneous, and the NFAH estimate was sensitive to PAH adjustment and criterion restriction, the adult-height finding should be interpreted cautiously. CI - Copyright (c) 2026 Jin, Wang, Qian, Zhang, Liu and Yang. FAU - Jin, Peili AU - Jin P AD - Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China. FAU - Wang, Duomei AU - Wang D AD - Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China. FAU - Qian, Minyan AU - Qian M AD - Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China. FAU - Zhang, Huimin AU - Zhang H AD - Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China. FAU - Liu, Chang AU - Liu C AD - Medical Affairs Department, GeneScience Pharmaceuticals, Changchun, Jilin, China. FAU - Yang, Rongwei AU - Yang R AD - Jiaxing Maternity and Child Health Care Hospital, Jiaxing, Zhejiang, China. LA - eng PT - Journal Article DEP - 20260918 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 33515-09-2 (Gonadotropin-Releasing Hormone) RN - 12629-01-5 (Human Growth Hormone) RN - 0 (Puberty Inhibitors) SB - IM MH - Humans MH - *Puberty, Precocious/drug therapy MH - Female MH - *Body Height/drug effects MH - *Gonadotropin-Releasing Hormone/analogs & derivatives/therapeutic use/administration & dosage MH - Retrospective Studies MH - *Human Growth Hormone/administration & dosage/therapeutic use MH - Puberty Inhibitors MH - Child MH - Puberty Suppression MH - Male MH - Cohort Studies MH - Prognosis MH - Adult PMC - PMC13630612 OTO - NOTNLM OT - central precocious puberty OT - confounding by indication OT - gonadotropin-releasing hormone analog OT - growth hormone OT - near-final adult height OT - observational methods OT - predicted adult height OT - validation audit COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/04 00:33 MHDA- 2026/10/04 00:34 PMCR- 2026/09/18 CRDT- 2026/10/03 05:28 PHST- 2026/05/19 00:00 [received] PHST- 2026/08/03 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/10/04 00:34 [medline] PHST- 2026/10/04 00:33 [pubmed] PHST- 2026/10/03 05:28 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.3389/fendo.2026.1885575 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 18;17:1885575. doi: 10.3389/fendo.2026.1885575. eCollection 2026. PMID- 42827228 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261005 IS - 1399-3038 (Electronic) IS - 0905-6157 (Print) IS - 0905-6157 (Linking) VI - 37 IP - 10 DP - 2026 Oct TI - Validation and reliability of the Italian versions of the Food Allergy Quality of Life -Parental Burden (FAQL-PB) and -Parent Form 10 (FAQLQ-PF10) Questionnaires. PG - e70510 LID - 10.1111/pai.70510 [doi] LID - e70510 AB - BACKGROUND: Food allergy (FA) may substantially impair quality of life (QoL) in affected children and their families. Reliable and culturally adapted tools are needed to assess this burden. We aimed to translate, culturally adapt, and validate the Italian versions of the Food Allergy Quality of Life Questionnaire Parent Form 10 (FAQLQ-PF10) and the Food Allergy Quality of Life Parental Burden Questionnaire (FAQL-PB). METHODS: Following World Health Organization recommendations, the questionnaires underwent forward-backward translation and psychometric validation. Internal consistency, test-retest reliability, convergent validity, and discriminant validity were assessed in caregivers of children with FA (n = 128) and without FA (n = 52). RESULTS: Both questionnaires showed high internal consistency (Cronbach's alpha = 0.87 for FAQLQ-PF10 and 0.95 for FAQL-PB) and excellent test-retest reliability (Intraclass Correlation Coefficients 0.95 and 0.87, respectively). Moderate correlations with the Food Allergy Independent Measure (FAIM) supported convergent validity, whereas weak correlations with generic QoL and psychological distress measures confirmed disease specificity. FAQLQ-PF10 and FAQL-PB scores were significantly higher in the FA group than in controls (all p < .0001), supporting discriminant validity. Key clinical predictors of worse QoL included history of anaphylaxis, allergic comorbidities, and previous emergency department visits for FA. Parents of children with milk or egg allergy were a high-risk subgroup for impaired QoL, whereas increasing child age, longer elimination diet duration, and multiple affected siblings were associated with worse child QoL. CONCLUSIONS: The Italian versions of the FAQLQ-PF10 and FAQL-PB are valid, reliable, and disease-specific instruments for assessing FA-related QoL. Their use may facilitate routine QoL assessment and support patient-centered management of pediatric FA. CI - (c) 2026 The Author(s). Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. FAU - Comberiati, Pasquale AU - Comberiati P AUID- ORCID: 0000-0001-5209-9733 AD - Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy. FAU - Barni, Simona AU - Barni S AUID- ORCID: 0000-0001-5598-2740 AD - Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy. FAU - Miccoli, Mario AU - Miccoli M AUID- ORCID: 0000-0002-8632-6145 AD - Department of Human and Social Sciences, Universita Mercatorum, Rome, Italy. FAU - DunnGalvin, Audrey AU - DunnGalvin A AUID- ORCID: 0000-0002-1540-3959 AD - School of Applied Psychology, University College Cork, Cork, Ireland. FAU - Mori, Francesca AU - Mori F AD - Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy. FAU - Sarti, Lucrezia AU - Sarti L AUID- ORCID: 0000-0001-8055-3788 AD - Allergy Unit, Department of Pediatrics, Meyer Children's University Hospital, Florence, Italy. FAU - Poli, Andrea AU - Poli A AUID- ORCID: 0000-0001-7163-9627 AD - Department of Human and Social Sciences, Universita Mercatorum, Rome, Italy. FAU - Munblit, Daniel AU - Munblit D AUID- ORCID: 0000-0001-9652-6856 AD - Inflammation, Repair and Development Section, NHLI, Imperial College London, London, UK. FAU - D'Auria, Enza AU - D'Auria E AUID- ORCID: 0000-0003-2750-5810 AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. AD - Allergy Unit, Department of Pediatrics, Buzzi Children's Hospital, Milan, Italy. FAU - Fleischer, David AU - Fleischer D AD - Department of Pediatrics, Section of Allergy/Immunology, Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Peroni, Diego G AU - Peroni DG AUID- ORCID: 0000-0002-0234-1373 AD - Department of Clinical and Experimental Medicine, Section of Pediatrics, University of Pisa, Pisa, Italy. FAU - Greenhawt, Mattew AU - Greenhawt M AUID- ORCID: 0000-0002-2365-9372 AD - Aquestive Therapeutics, Inc, Warren, New Jersey, USA. LA - eng PT - Journal Article PT - Validation Study PL - England TA - Pediatr Allergy Immunol JT - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JID - 9106718 SB - IM MH - Humans MH - *Quality of Life MH - *Food Hypersensitivity/psychology/epidemiology/diagnosis MH - Male MH - Female MH - Surveys and Questionnaires MH - Italy MH - Child MH - Reproducibility of Results MH - *Parents/psychology MH - Child, Preschool MH - Psychometrics MH - Adolescent MH - Adult MH - Cost of Illness MH - Caregivers/psychology PMC - PMC13633388 OTO - NOTNLM OT - FAQLQ-PF10 OT - FAQL-PB OT - caregivers OT - children OT - food allergy OT - quality of life OT - questionnaires COIS- Simona Barni reports personal fees from Nutricia, Sanofi, and Firma. David Fleischer has received grant support from Aquestive, ARS Pharmaceuticals, DBV Technologies, N-Fold; receives royalties from UpToDate; serves as a consultant to Aquestive, ARS Pharmaceuticals, DBV Technologies, Genentech, Nasus Pharma; and has stock options in Nasus Pharma and Grow Happy. Matt Greenhawt is the chief medical officer for Aquestive Therapeutics, Inc. He is a speaker for Genentech. He is a former consultant to Aquestive; speaker for ARS; advisory board member for Aquestive, DBV, Novartis, Nutricia, Genentech, ALK, Prota; former senior associate editor for Annals of Allergy, Asthma, and Immunology; served as chief medical officer for the Asthma and Allergy Foundation of America; serves as a member of the Brighton Collaboration Criteria Vaccine Anaphylaxis 2.0 working group. His work on this manuscript occurred while at Children's Hospital Colorado, but critical manuscript review and approval occurred at his current employer. His views on this manuscript are his own and not necessarily reflective of Aquestive Therapeutics, Inc. The rest of the authors declare that they have no relevant conflicts of interest. EDAT- 2026/10/03 05:33 MHDA- 2026/10/03 05:34 PMCR- 2026/10/03 CRDT- 2026/10/02 23:22 PHST- 2026/08/26 00:00 [revised] PHST- 2026/06/09 00:00 [received] PHST- 2026/09/23 00:00 [accepted] PHST- 2026/10/03 05:34 [medline] PHST- 2026/10/03 05:33 [pubmed] PHST- 2026/10/02 23:22 [entrez] PHST- 2026/10/03 00:00 [pmc-release] AID - PAI70510 [pii] AID - 10.1111/pai.70510 [doi] PST - ppublish SO - Pediatr Allergy Immunol. 2026 Oct;37(10):e70510. doi: 10.1111/pai.70510. PMID- 42827062 OWN - NLM STAT- Publisher LR - 20261002 IS - 1878-4046 (Electronic) IS - 1076-6332 (Linking) DP - 2026 Oct 2 TI - CT Radiomics of Epicardial Adipose Tissue for Predicting Atrial Fibrillation: A Systematic Review. LID - S1076-6332(26)00686-0 [pii] LID - 10.1016/j.acra.2026.08.071 [doi] AB - RATIONALE AND OBJECTIVES: Atrial fibrillation (AF) is the most common arrhythmia, affecting 1-2% of the general population. Epicardial adipose tissue (EAT) may contribute to AF through its proximity to the myocardium and coronary vessels, as well as its vasocrine and paracrine functions. Previous studies linked EAT thickness and volume with AF incidence. This review consolidates evidence on the correlation between radiomic analysis of EAT and the incidence of AF. MATERIAL AND METHODS: This systematic review was conducted in accordance with PRISMA 2020 and registered in the International Prospective Register of Systematic Reviews (PROSPERO). Embase, PubMed, MEDLINE, Web of Science, and Google Scholar were searched for primary studies using CT-based EAT radiomics to predict AF. Case reports, animal studies, pediatric populations, and Magnetic Resonance Imaging (MRI)/ultrasound studies were excluded. Risk of bias was assessed with PROBAST, and methodological quality with the Radiomics Quality Score. RESULTS: Ten studies, including 2952 patients (53.8-81.4% male; mean age range 42.2-74.1 years), met eligibility. Six were retrospective, and four were prospective. The studies evaluated postoperative AF, AF recurrence after catheter ablation, AF detection, and AF subtype classification. Reported machine learning models included random forest, logistic regression, Cox regression, and Least Absolute Shrinkage and Selection Operator (LASSO). Performance metrics ranged from AUC 0.73-0.92, sensitivity 0.50-0.90 and specificity 0.53-0.98. Segmentation methods and feature extraction varied, and external validation was rare. CONCLUSION: Machine learning models using EAT radiomic features show promise for AF prediction. However, this heterogeneity limits generalizability and precludes immediate incorporation into clinical practice. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Gladkiy, Yevgeniy AU - Gladkiy Y AD - Boonshoft School of Medicine, Wright State University, Dayton, Ohio. FAU - Hasheminia, Amin AU - Hasheminia A AD - McGill Faculty of Medicine and Health Sciences, Montreal, QC Canada. FAU - Elsherbini, Adham AU - Elsherbini A AD - Temerty Faculty of Medicine, Toronto, ON, Canada. FAU - Kassas, Mutaz AU - Kassas M AD - Institut Jules Bordet, Hopital Universitaire de Bruxelles, Universite Libre de Bruxelles, Bruxelles, Belgium. FAU - Boyes, Daniel AU - Boyes D AD - Boonshoft School of Medicine, Wright State University, Dayton, Ohio. FAU - Faddoul, Daniel AU - Faddoul D AD - Department of Biological Sciences, George Washington University, Washington, District of Columbia. FAU - Gilkeson, Robert AU - Gilkeson R AD - Department of Radiology, University Hospitals Cleveland Medical Center, Cleveland, Ohio. FAU - El Diasty, Mohammad AU - El Diasty M AD - Faculty of Health Sciences, Queen's University, Kingston, ON Canada; Department of Cardiac Surgery, Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, 11100 Euclid Ave̥, Cleveland, Ohio 44106. Electronic address: cardiac.science.lab@gmail.com. LA - eng PT - Journal Article PT - Review DEP - 20261002 PL - United States TA - Acad Radiol JT - Academic radiology JID - 9440159 SB - IM OTO - NOTNLM OT - Atrial Fibrillation (AF) OT - Computed Tomography (CT) OT - Epicardial Adipose Tissue (EAT) OT - Machine Learning OT - Radiomics COIS- Declaration of Competing Interest All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. EDAT- 2026/10/02 23:30 MHDA- 2026/10/02 23:30 CRDT- 2026/10/02 21:53 PHST- 2025/11/09 00:00 [received] PHST- 2026/08/10 00:00 [revised] PHST- 2026/08/15 00:00 [accepted] PHST- 2026/10/02 23:30 [medline] PHST- 2026/10/02 23:30 [pubmed] PHST- 2026/10/02 21:53 [entrez] AID - S1076-6332(26)00686-0 [pii] AID - 10.1016/j.acra.2026.08.071 [doi] PST - aheadofprint SO - Acad Radiol. 2026 Oct 2:S1076-6332(26)00686-0. doi: 10.1016/j.acra.2026.08.071. PMID- 42826378 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261019 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Oct 2 TI - Development and Validation of an Extraoral Condyle Locating Device and Its Effect on Low-Level Laser Therapy in Patients With Skeletal Class II Malocclusion: Protocol for a 2-Phase Randomized Controlled Trial. PG - e94481 LID - 10.2196/94481 [doi] LID - e94481 AB - BACKGROUND: Precise localization of the mandibular condyle is essential for extraoral therapeutic procedures such as low-level laser therapy (LLLT) in patients with skeletal class II malocclusion undergoing myofunctional appliance therapy. Conventional localization methods rely on palpation and visual estimation, which are operator dependent and may compromise reproducibility and treatment outcomes. To address this limitation, a spectacle-mounted extraoral condyle locating device (EOCLD) has been developed to facilitate accurate and consistent condylar targeting. OBJECTIVE: This study aims to develop and validate the EOCLD for precise condylar localization and evaluate its impact on the clinical efficacy of LLLT in patients with skeletal class II malocclusion undergoing myofunctional appliance therapy. METHODS: This 2-phase study will be conducted in patients aged 10 to 13 years in a growth phase with skeletal class II malocclusion. In phase 1, the EOCLD will be evaluated for accuracy and reproducibility using standardized lateral cephalometric imaging. In phase 2, a prospective randomized controlled trial will be conducted in which participants undergoing myofunctional appliance therapy will be randomly allocated to either EOCLD-guided LLLT or conventional unguided LLLT. Skeletal and dentoalveolar changes will be assessed using standardized cephalometric analyses, while condylar growth and mandibular changes will be evaluated using pretreatment and posttreatment cone beam computed tomography (CBCT) imaging. Treatment duration, patient-reported comfort, and compliance will also be assessed. RESULTS: The study is self-funded and received approval from the institutional ethics committee on November 28, 2025. Phase 1 data collection took place from May 21 to August 30, 2026, with EOCLD validation performed in 50 participants. As of September 2026, the data are undergoing statistical analysis. Phase 2 is scheduled to commence on December 1, 2026. CONCLUSIONS: This study will establish the clinical validity of the EOCLD and determine whether guided LLLT enhances treatment efficiency and skeletal outcomes in skeletal class II therapy. TRIAL REGISTRATION: Clinical Trials Registry-India CTRI/2026/02/102982; https://tinyurl.com/4t3bwrnz. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/94481. CI - (c)Shilpa Kendre, Pallavi Daigavane. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 02.10.2026. FAU - Kendre, Shilpa AU - Kendre S AUID- ORCID: 0000-0002-4024-1744 AD - Department of Orthodontics, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. FAU - Daigavane, Pallavi AU - Daigavane P AUID- ORCID: 0000-0001-7205-8154 AD - Department of Orthodontics, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20261002 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Cephalometry/methods MH - *Low-Level Light Therapy/methods/instrumentation MH - *Malocclusion, Angle Class II/therapy MH - *Mandibular Condyle/diagnostic imaging MH - Randomized Controlled Trials as Topic MH - Reproducibility of Results MH - Validation Studies as Topic PMC - PMC13675681 OTO - NOTNLM OT - CBCT OT - EOCLD OT - LLLT OT - condylar growth OT - condylar localization OT - cone beam computed tomography OT - extraoral condyle locating device OT - functional orthopedics OT - laser-assisted orthodontics OT - low-level laser therapy OT - myofunctional appliance therapy OT - randomized controlled trial OT - skeletal class II COIS- Conflicts of Interest: None declared. EDAT- 2026/10/02 17:30 MHDA- 2026/10/02 23:30 PMCR- 2026/10/02 CRDT- 2026/10/02 16:53 PHST- 2026/03/02 00:00 [received] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/06/03 00:00 [revised] PHST- 2026/10/02 23:30 [medline] PHST- 2026/10/02 17:30 [pubmed] PHST- 2026/10/02 16:53 [entrez] PHST- 2026/10/02 00:00 [pmc-release] AID - v15i1e94481 [pii] AID - 10.2196/94481 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Oct 2;15:e94481. doi: 10.2196/94481. PMID- 42825020 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261003 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Liver transplantation-related osteoporosis and fragility fractures: pathogenic pathways, risk stratification and novel targeted therapy advances. PG - 1965784 LID - 10.3389/fimmu.2026.1965784 [doi] LID - 1965784 AB - Liver transplantation (LT) serves as the definitive treatment for end-stage liver disease. Yet, osteoporosis (OP) and fragility fractures remain frequently overlooked skeletal complications that may impair the long-term prognosis of recipients. This review systematically summarizes recent evidence regarding epidemiological characteristics, multifactorial pathogenic pathways, risk stratification approaches, and advances in targeted interventions for LT-related bone disorders. Skeletal damage distributes across pre-transplant waiting, early post-transplant acute and long-term chronic phases; rapid bone loss and elevated fracture risk potentially peak within the first year after LT. Pre-transplant hepatic dysfunction-induced malnutrition, endocrine disturbance, and chronic inflammation lay baseline skeletal impairment. In contrast, perioperative high-dose glucocorticoids, calcineurin inhibitor toxicity, surgical denervation, and ischemia-reperfusion injury may jointly drive substantial elevation of bone turnover in the early post-transplant stage. Long-term cortical bone repair deficiency could be attributed to persistent secondary hyperparathyroidism, post-transplant diabetes, and genetic susceptibility. Dual-energy X-ray absorptiometry remains the standard bone mineral density diagnostic tool, while vertebral computed tomography attenuation value and simplified clinical scoring systems support auxiliary risk stratification for skeletal health. Generalized nutritional and lifestyle interventions combined with anti-resorptive agents form mainstream management schemes; DKK-1/Wnt/beta-catenin pathway-targeted therapy shows potential as a novel intervention direction. Pediatric LT recipients feature unique bone maturation characteristics that require age-specific evaluation criteria, though unified standardized protocols remain insufficient. Current clinical practice suffers from inadequate bone health screening and pharmacotherapy coverage. Further prospective trials are warranted to validate optimized stratified screening algorithms and individualized targeted regimens for high-risk LT populations. CI - Copyright (c) 2026 Wang and Wang. FAU - Wang, Meiqi AU - Wang M AD - Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, China. FAU - Wang, Qi AU - Wang Q AD - Department of Donation Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. LA - eng PT - Journal Article PT - Review DEP - 20260917 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 SB - IM MH - Humans MH - *Liver Transplantation/adverse effects MH - *Osteoporosis/etiology/therapy/epidemiology/diagnosis MH - *Osteoporotic Fractures/etiology/therapy MH - Risk Assessment MH - Risk Factors MH - Animals MH - Bone Density PMC - PMC13628645 OTO - NOTNLM OT - Wnt/beta-Catenin pathway OT - bone mineral density OT - fragility fracture OT - hepatic osteodystrophy OT - liver transplantation OT - osteoporosis OT - risk stratification COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 13:37 MHDA- 2026/10/02 13:38 PMCR- 2026/09/17 CRDT- 2026/10/02 07:06 PHST- 2026/08/12 00:00 [received] PHST- 2026/09/01 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/02 13:38 [medline] PHST- 2026/10/02 13:37 [pubmed] PHST- 2026/10/02 07:06 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1965784 [doi] PST - epublish SO - Front Immunol. 2026 Sep 17;17:1965784. doi: 10.3389/fimmu.2026.1965784. eCollection 2026. PMID- 42824923 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261003 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Predictors of treatment response to semaglutide for weight management. PG - 1893511 LID - 10.3389/fendo.2026.1893511 [doi] LID - 1893511 AB - The emergence of weekly, injectable glucagon-like peptide-1 (GLP-1) receptor agonists has revolutionized the obesity management landscape. Numerous studies have shown high efficacy as well as great variability in weight loss, highlighting the need for this mini review, summarizing current evidence about predictors of semaglutide-related weight loss. The first well-known determinant of semaglutide-induced weight loss is the presence of type 2 DM which is associated with significantly lower body weight reduction. The second predictor is sex, with females exhibiting a greater weight loss than males by a mean 6%. In addition, higher maintenance dose of 7.2 mg is superior to standard 2.4 mg dose in weight reduction by a mean 3%. There is no clear association of age and baseline body mass index with the magnitude of semaglutide-driven weight loss, except for the possibility of adolescence enhancing and overweight reducing this treatment effect. The potential impact of genetic polymorphisms of individual treatment response to semaglutide remains incompletely understood, limited so far to a modest effect of specific variants in GLP1 receptor gene. Another potential predictor of response could be obesity phenotype, with preliminary data supporting greater effectiveness of semaglutide in individuals with ''hungry gut'' phenotype. Type of lifestyle modification does not seem to have a significant effect on the variability of semaglutide-driven weight loss. Further studies are needed to expand knowledge about predictors of response to semaglutide, paving the way for validated predictive models in order to guide clinical decision-making and provision of personalized obesity care. CI - Copyright (c) 2026 Tzoulis. FAU - Tzoulis, Ploutarchos AU - Tzoulis P AD - Research Department of Experimental and Translational Medicine, University College London, London, United Kingdom. LA - eng PT - Journal Article PT - Review DEP - 20260917 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 53AXN4NNHX (Semaglutide) RN - 62340-29-8 (Glucagon-Like Peptides) RN - 0 (Anti-Obesity Agents) RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) RN - 0 (Glucagon-Like Peptide-1 Receptor) SB - IM MH - Semaglutide MH - Humans MH - *Glucagon-Like Peptides/therapeutic use MH - *Obesity/drug therapy MH - *Weight Loss/drug effects MH - *Anti-Obesity Agents/therapeutic use MH - Diabetes Mellitus, Type 2/drug therapy MH - Glucagon-Like Peptide-1 Receptor Agonists MH - Treatment Outcome MH - Glucagon-Like Peptide-1 Receptor/genetics PMC - PMC13628350 OTO - NOTNLM OT - GLP-1 agonist OT - antiobesity agent OT - obesity OT - semaglutide OT - weight loss COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 13:36 MHDA- 2026/10/02 13:37 PMCR- 2026/09/17 CRDT- 2026/10/02 06:56 PHST- 2026/05/28 00:00 [received] PHST- 2026/07/14 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/10/02 13:37 [medline] PHST- 2026/10/02 13:36 [pubmed] PHST- 2026/10/02 06:56 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - 10.3389/fendo.2026.1893511 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 17;17:1893511. doi: 10.3389/fendo.2026.1893511. eCollection 2026. PMID- 42824878 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261002 LR - 20261003 IS - 1662-5161 (Print) IS - 1662-5161 (Electronic) IS - 1662-5161 (Linking) VI - 20 DP - 2026 TI - Development, validation and effectiveness of a parents led neuromotor training module with AI-based movement analysis for improving motor proficiency and sports participation in children with developmental coordination disorder: a protocol for an assessor-blinded randomized superiority controlled trial. PG - 1931622 LID - 10.3389/fnhum.2026.1931622 [doi] LID - 1931622 AB - INTRODUCTION: Developmental Coordination Disorder (DCD) is a common neurodevelopmental condition characterized by impaired motor coordination, poor balance, reduced participation in physical activities, and limitations in functional performance. Conventional rehabilitation often requires prolonged therapist supervision and may not be consistently accessible, particularly in resource-limited settings. Parent-led rehabilitation and artificial intelligence (AI)-based movement analysis have emerged as promising approaches to enhance motor outcomes; however, evidence integrating these strategies remains limited. This manuscript presents the protocol for a randomized controlled trial evaluating a structured Parent-Led Neuromotor Training Programme integrated with AI-based movement analysis in children with DCD. METHODS AND ANALYSIS: This protocol describes an assessor-blinded, two-arm, parallel-group randomized superiority controlled trial involving 62 children aged 7-14 years diagnosed with DCD according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria and scoring below the age-expected range on the Movement Assessment Battery for Children-Second Edition (MABC-2). Participants will be randomly allocated (1:1) to either an intervention group receiving a Parent-Led Neuromotor Training Programme integrated with AI-based movement analysis in addition to conventional physiotherapy or a control group receiving conventional physiotherapy alone. Parents will deliver supervised home-based training for 30-45 min per session, 5 days per week, for 12 weeks. Movement analysis will be performed using Google MediaPipe Pose, a validated markerless pose-estimation framework, to quantify joint kinematics, movement symmetry, coordination, movement smoothness, movement accuracy, movement speed, and task-completion time from standardized video recordings. The primary outcome will be motor proficiency, assessed using the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition (BOT-2). Secondary outcomes will include AI-based movement metrics such as symmetry index, movement variability, and coordination score, as well as parental adherence, engagement, satisfaction, balance, and agility outcomes, parental adherence and satisfaction, and AI-derived movement metrics. The sample size was calculated to detect a clinically meaningful between-group difference with 80% power at a 5% significance level. Statistical analyses will follow the intention-to-treat principle, with linear mixed-effects models used to compare repeated measurements between groups. Missing data will be handled using appropriate imputation methods where necessary. CLINICAL TRIAL REGISTRATION: https://ctri.nic.in/Clinicaltrials/regtrial.php?trialid=164461&EncHid=98252.11023&modid=1&compid=19 Identifier [CTRI/2026/06/112632]. CI - Copyright (c) 2026 Hullumani and Qureshi. FAU - Hullumani, Sharath AU - Hullumani S AD - Department of Pediatrics Physiotherapy, Ravi Nair Physiotherapy College, Datta Meghe Institute Higher Education and Research (DU), Wardha, India. FAU - Qureshi, Irshad AU - Qureshi I AD - Department of Neuro Physiotherapy, Ravi Nair Physiotherapy College, Datta Meghe Institute Higher Education and Research (DU), Wardha, India. LA - eng PT - Journal Article DEP - 20260911 PL - Switzerland TA - Front Hum Neurosci JT - Frontiers in human neuroscience JID - 101477954 PMC - PMC13628172 OTO - NOTNLM OT - DCD OT - artificial intelligence OT - developmental coordiantion disorder OT - media pipe OT - neuromotor training OT - parent led OT - physical therapy OT - therapist supervision COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 13:37 MHDA- 2026/10/02 13:38 PMCR- 2026/09/11 CRDT- 2026/10/02 06:52 PHST- 2026/07/08 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/10/02 13:38 [medline] PHST- 2026/10/02 13:37 [pubmed] PHST- 2026/10/02 06:52 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 10.3389/fnhum.2026.1931622 [doi] PST - epublish SO - Front Hum Neurosci. 2026 Sep 11;20:1931622. doi: 10.3389/fnhum.2026.1931622. eCollection 2026. PMID- 42824713 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261002 LR - 20261004 IS - 2666-142X (Electronic) IS - 2666-142X (Linking) VI - 11 DP - 2026 Dec TI - Background and design of the empowering cardiovascular health in grandfamilies (ECHG) study: A mixed methods study research protocol. PG - 100654 LID - 10.1016/j.ijnsa.2026.100654 [doi] LID - 100654 AB - A steady increase in the number of grandparent caregivers - accelerated by recent trends such as children orphaned by the COVID-19 pandemic or the opioid crisis - magnifies the importance of addressing cardiovascular disease (CVD) risk in that already at high-risk group. However, few efforts have directly addressed the specific cardiac health needs of grandparent primary caregivers (or custodial grandparents). In this paper, we describe the research protocol for the Rural Caregiver Heart Health Education (RICHH) intervention for implementation with grandparent caregivers (RICHH-GP) study funded by the National Institute of Heart, Lung, and Blood. This study will tailor an existing CVD risk reduction intervention (RICHH) for implementation with grandparent primary caregivers and then test the modified design for feasibility, acceptability, and preliminary efficacy. The expected outcome of RICHH-GP is to establish the groundwork for an expanded future clinical trial in which we will test effectiveness with a longer follow-up and with increased inclusivity of participants from marginalized populations. The specific aims are: 1) modify the RICHH intervention to target custodial grandparents from a variety of backgrounds; 2) employ the tailored intervention and assess its feasibility and acceptability via a 2-arm randomized controlled trial; 3) test the preliminary efficacy of RICHH-GP based on measures of CVD risk (physical activity, dietary intake, nicotine exposure, sleep, body mass index, lipids, blood pressure, and HbA1c), self-management behaviors, and depressive symptoms at 4- and 6-months compared to baseline and; 4) (exploratory) examine the proximal impact of the RICHH-GP intervention on CVD risk and depressive symptoms on a subsample of grandchildren of the grandparent participants. The ultimate objectives of this work are to prevent CVD-related morbidity and mortality and overall physical decline, improve psychological well-being among grandparent caregivers, and foster a more heart-healthy environment in grandfamilies. CI - (c) 2026 The Authors. FAU - Song, MinKyoung AU - Song M AD - School of Nursing, Oregon Health & Science University, Portland, OR, USA. FAU - Hansen, Lissi AU - Hansen L AD - School of Nursing, Oregon Health & Science University, Portland, OR, USA. FAU - Musil, Carol M AU - Musil CM AD - Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA. FAU - Dieckmann, Nathan F AU - Dieckmann NF AD - School of Nursing, Oregon Health & Science University, Portland, OR, USA. FAU - Rosenkranz, Susan J AU - Rosenkranz SJ AD - School of Nursing, Oregon Health & Science University, Portland, OR, USA. FAU - Moser, Debra K AU - Moser DK AD - College of Nursing, University of Tennessee, Knoxville, Knoxville, TN, USA. LA - eng GR - R34 HL177243/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260812 PL - England TA - Int J Nurs Stud Adv JT - International journal of nursing studies advances JID - 101769252 PMC - PMC13629207 OTO - NOTNLM OT - Cardiovascular diseases OT - Caregivers OT - Grandparents OT - Randomized controlled trial COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/10/02 13:36 MHDA- 2026/10/02 13:37 PMCR- 2026/08/12 CRDT- 2026/10/02 06:39 PHST- 2026/07/29 00:00 [received] PHST- 2026/08/08 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/10/02 13:37 [medline] PHST- 2026/10/02 13:36 [pubmed] PHST- 2026/10/02 06:39 [entrez] PHST- 2026/08/12 00:00 [pmc-release] AID - S2666-142X(26)00175-X [pii] AID - 100654 [pii] AID - 10.1016/j.ijnsa.2026.100654 [doi] PST - epublish SO - Int J Nurs Stud Adv. 2026 Aug 12;11:100654. doi: 10.1016/j.ijnsa.2026.100654. eCollection 2026 Dec. PMID- 42824389 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261020 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Improvements in body composition and postural control in children with obesity following an AI-assisted, deficit-oriented exercise intervention. PG - 1886988 LID - 10.3389/fpubh.2026.1886988 [doi] LID - 1886988 AB - OBJECTIVE: To investigate the effects of an AI-assisted, individualized exercise management model on body composition, physical fitness, and postural stability in children with obesity, providing a feasibility foundation for subsequent randomized controlled trials. METHODS: A single-group, pre-post pilot study was conducted. Nineteen children with simple obesity (7 girls, 12 boys; mean age 10.11 +/- 2.0 years) from West China Second Hospital (July-September 2024) completed a 12-week exercise intervention. The AI system generated individualized FITT-VP prescriptions based on baseline assessments and dynamically adjusted them via training feedback, with on-site coach implementation. Outcomes were measured pre- and post-intervention. RESULTS: All 19 children completed the intervention with no adverse events. Primary outcomes: BMI decreased from 25.29 +/- 3.56 to 23.64 +/- 3.60 kg/m(2) (p < 0.001, d = 0.46), and body fat mass from 21.06 +/- 6.70 to 17.94 +/- 6.69 kg (p < 0.001, d = 0.47). Secondary outcomes: waist circumference (p < 0.01, d = 0.31), grip strength (p < 0.01, d = 0.54), 1-min jump rope (p < 0.01, d = 1.15), 1-min sit-ups (p < 0.05, d = 1.00), and sit-and-reach (p < 0.05, d = 0.67) all improved significantly. In the eight-directional postural control assessment, endpoint excursion and maximum excursion exhibited improvement trends in all directions, and reaction time was significantly reduced in four directions (p < 0.05). In the Sensory Organization Test, the mean balance percentages for SOT-4 and SOT-5 significantly increased (p < 0.01, d = 1.05 and d = 0.58, respectively), and the composite balance score increased by 24.15% (p < 0.001, d = 1.28). The visual ratio significantly increased by 19.5% (p < 0.05, d = 0.80), whereas the vestibular ratio increased by 15.3%, approaching but not reaching statistical significance (p = 0.054, d = 0.43). CONCLUSION: The AI-assisted, deficit-oriented exercise intervention demonstrated good feasibility and safety in this cohort of children with obesity. The observed improvements in body composition, motor function, and postural control indicators provide a feasibility basis for subsequent confirmatory trials on precision exercise management for childhood obesity. CI - Copyright (c) 2026 Cao, Cheng, Deng, Ren, Zhang and Li. FAU - Cao, Lixin AU - Cao L AD - School of Sport Medicine and Health, Chengdu Sport University, Jianyang, Sichuan Province, China. FAU - Cheng, Xingxing AU - Cheng X AD - School of Sport Medicine and Health, Chengdu Sport University, Jianyang, Sichuan Province, China. FAU - Deng, Changqing AU - Deng C AD - School of Sport Medicine and Health, Chengdu Sport University, Jianyang, Sichuan Province, China. FAU - Ren, Yuexin AU - Ren Y AD - School of Sport Medicine and Health, Chengdu Sport University, Jianyang, Sichuan Province, China. FAU - Zhang, Shunjiu AU - Zhang S AD - School of Sport Medicine and Health, Chengdu Sport University, Jianyang, Sichuan Province, China. FAU - Li, Lunyu AU - Li L AD - School of Sport Medicine and Health, Chengdu Sport University, Jianyang, Sichuan Province, China. LA - eng PT - Journal Article DEP - 20260917 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - *Body Composition/physiology MH - *Postural Balance/physiology MH - *Pediatric Obesity/therapy MH - Physical Fitness/physiology MH - Body Mass Index MH - Pilot Projects MH - Artificial Intelligence MH - Humans MH - Male MH - Female MH - Child PMC - PMC13627403 OTO - NOTNLM OT - AI-assisted decision support system OT - childhood obesity OT - deficit-oriented OT - postural control OT - precision exercise intervention COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 13:37 MHDA- 2026/10/02 13:38 PMCR- 2026/09/17 CRDT- 2026/10/02 06:06 PHST- 2026/05/21 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/02 13:38 [medline] PHST- 2026/10/02 13:37 [pubmed] PHST- 2026/10/02 06:06 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1886988 [doi] PST - epublish SO - Front Public Health. 2026 Sep 17;14:1886988. doi: 10.3389/fpubh.2026.1886988. eCollection 2026. PMID- 42824331 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261003 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Predicting metabolic syndrome in adolescents from device-measured 24-h movement behaviors: a machine learning approach. PG - 1928562 LID - 10.3389/fpubh.2026.1928562 [doi] LID - 1928562 AB - OBJECTIVE: To develop and internally evaluate a non-invasive machine-learning model for identifying metabolic syndrome (MS) in adolescents using 24-h movement behaviors and non-invasively measured physical characteristics. METHODS: This cross-sectional study included 822 adolescents aged 12-15 years recruited in Tianjin, China, from September 2023 to September 2025. Movement behaviors were assessed using ActiGraph GT3X+ accelerometers, body composition was measured using dual-energy X-ray absorptiometry, and MS was diagnosed according to the 2007 International Diabetes Federation criteria. LASSO regression was used for feature selection, and 13 machine-learning algorithms were compared. SMOTETomek was used during model development to address class imbalance. Performance was evaluated using stratified five-fold cross-validation and a held-out internal test set. SHapley Additive exPlanations (SHAP) were used to interpret model predictions. RESULTS: LASSO retained eight predictors: waist circumference, body fat percentage (FAT%), weight, age, moderate physical activity (MPA), vigorous physical activity, sleep duration, and sex. Extra Trees achieved the best cross-validation performance, with a mean AUC of 0.749 (SD, 0.043) and an F1 score of 0.798 (SD, 0.028). Its relative advantage may reflect the ability of randomized tree ensembles to capture nonlinear relationships and feature interactions while reducing variance through aggregation. In the held-out internal test set, the model achieved an AUC of 0.864, accuracy of 92.02%, specificity of 93.33%, and sensitivity of 76.92%. The lower sensitivity relative to accuracy and specificity indicates that some adolescents with MS may remain undetected. SHAP ranked FAT% as the most influential predictor (mean absolute SHAP value, 0.08) and MPA as the leading movement-behavior predictor (0.04), thereby improving the transparency of model predictions. CONCLUSIONS: The Extra Trees model showed moderate cross-validation discrimination and stronger performance in the internal test set, although this difference warrants cautious interpretation. SHAP improved model transparency by identifying FAT% and MPA as influential predictors. Multicenter external validation and feasibility assessment are required before large-scale screening. CI - Copyright (c) 2026 Cao, Feng, Wang and Wang. FAU - Cao, Liquan AU - Cao L AD - Tianjin University of Sport, Tianjin, China. AD - Tianjin Key Laboratory of Sports and Health Integration and Health Promotion, Tianjin, China. FAU - Feng, Zhanpeng AU - Feng Z AD - Tianjin University of Sport, Tianjin, China. AD - Tianjin Key Laboratory of Sports and Health Integration and Health Promotion, Tianjin, China. FAU - Wang, Jing AU - Wang J AD - Tianjin University of Sport, Tianjin, China. FAU - Wang, Yun AU - Wang Y AD - Tianjin University of Sport, Tianjin, China. LA - eng PT - Journal Article DEP - 20260917 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Metabolic Syndrome/diagnosis MH - Adolescent MH - *Machine Learning MH - Cross-Sectional Studies MH - Female MH - Male MH - China MH - Predictive Learning Models MH - Child MH - *Exercise/physiology MH - Accelerometry MH - Absorptiometry, Photon MH - Prediction Algorithms PMC - PMC13627327 OTO - NOTNLM OT - 24-hour movement behaviors OT - SHAP OT - adolescent OT - machine learning OT - metabolic syndrome COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 13:37 MHDA- 2026/10/02 13:38 PMCR- 2026/09/17 CRDT- 2026/10/02 05:59 PHST- 2026/07/05 00:00 [received] PHST- 2026/08/23 00:00 [revised] PHST- 2026/08/30 00:00 [accepted] PHST- 2026/10/02 13:38 [medline] PHST- 2026/10/02 13:37 [pubmed] PHST- 2026/10/02 05:59 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1928562 [doi] PST - epublish SO - Front Public Health. 2026 Sep 17;14:1928562. doi: 10.3389/fpubh.2026.1928562. eCollection 2026. PMID- 42824137 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261003 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Mediating role of peripheral thyroid hormone conversion efficiency in the association between BMI and IGF-1 in children with growth retardation: a cross-sectional study. PG - 1941425 LID - 10.3389/fendo.2026.1941425 [doi] LID - 1941425 AB - OBJECTIVE: To examine the association between body mass index (BMI) standard deviation score (SDS) and insulin-like growth factor-1 (IGF-1) SDS and whether thyroid hormones mediate it, focusing on the peripheral conversion marker free triiodothyronine/free thyroxine (FT3/FT4) ratio, in prepubertal children (2.0-9.0 years) with height SDS < -1.0. METHODS: This retrospective cross-sectional study included 1,242 such children. Restricted cubic splines assessed the BMI-IGF-1 relationship, and Bootstrap mediation (5,000 resamples) tested indirect effects of FT3/FT4, FT3, FT4, and thyroid-stimulating hormone (TSH), adjusted for sex, age and height SDS. Reverse mediation, subgroup, interaction, Monte Carlo power, and E-value sensitivity analyses were also performed. RESULTS: A significant linear positive association was found (P-overall < 0.001; P-nonlinear = 0.0719). FT3/FT4 and FT3 showed significant partial mediation, accounting for 9.12% (P < 0.001) and 11.60% (P = 0.0108) of the total effect, respectively; TSH and FT4 did not. Sensitivity analyses confirmed robustness after stricter prepubertal cutoffs and exclusion of overweight/obese children. Notably, only FT3/FT4 remained significant after excluding suspected Growth Hormone Deficiency (GHD) (IGF-1 SDS < -2.0). The FT3/FT4 ratio remained a significant mediator across all subgroup analyses. Reverse mediation analysis yielded a substantially smaller indirect effect in the reverse direction. E-values for FT3/FT4 and FT3 were 1.0764 and 1.0609, respectively. CONCLUSION: In this growth-retarded prepubertal cohort, BMI and IGF-1 are linearly associated. The FT3/FT4 ratio is statistically supported as a partial mediator with moderate effect size but strong statistical robustness, while the central TSH pathway is uninvolved, supporting a peripheral "thrifty" regulatory strategy and offering a potential target for nutritional intervention. These mediation findings reflect statistical associations and require prospective validation. CI - Copyright (c) 2026 Zhang and Liu. FAU - Zhang, Mengying AU - Zhang M AD - Department of Child Health Care; Clinical Research Center of Child Health Care and Developmental & Behavioral Disorders, Institute of Maternal and Child Health, Wuhan Children's Hospital (Wuhan Maternal and Child Health Care Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China. FAU - Liu, Hua AU - Liu H AD - Department of Child Health Care; Clinical Research Center of Child Health Care and Developmental & Behavioral Disorders, Institute of Maternal and Child Health, Wuhan Children's Hospital (Wuhan Maternal and Child Health Care Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China. LA - eng PT - Journal Article DEP - 20260917 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 0 (Thyroid Hormones) RN - 0 (IGF1 protein, human) RN - Q51BO43MG4 (Thyroxine) RN - 06LU7C9H1V (Triiodothyronine) SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Insulin-Like Growth Factor I/metabolism/analysis MH - Female MH - *Body Mass Index MH - Child MH - Retrospective Studies MH - Child, Preschool MH - Male MH - *Growth Disorders/blood/metabolism MH - *Thyroid Hormones/blood/metabolism MH - Thyroxine/blood MH - *Triiodothyronine/blood PMC - PMC13627020 OTO - NOTNLM OT - FT3/FT4 ratio OT - body mass index OT - growth retardation OT - insulin-like growth factor-1 OT - mediation analysis OT - prepubertal children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 13:37 MHDA- 2026/10/02 13:38 PMCR- 2026/09/17 CRDT- 2026/10/02 05:30 PHST- 2026/07/18 00:00 [received] PHST- 2026/08/31 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/10/02 13:38 [medline] PHST- 2026/10/02 13:37 [pubmed] PHST- 2026/10/02 05:30 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - 10.3389/fendo.2026.1941425 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 17;17:1941425. doi: 10.3389/fendo.2026.1941425. eCollection 2026. PMID- 42823676 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261003 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Aug 13 TI - Artificial intelligence attitudes in relation to Mediterranean diet adherence and environmental footprints: a cross-sectional study. LID - 10.1186/s12889-026-28997-4 [doi] LID - 2730 AB - OBJECTIVE: This study aimed to evaluate the relationship between attitudes towards artificial intelligence and adherence to the Mediterranean Diet (MD), carbon footprint awareness and environmental footprint awareness among adults. METHODS: This cross-sectional study was conducted in Ankara, Turkey, using snowball sampling and an online questionnaire. The study included 1350 adults aged 18-65 years. Data were collected through a questionnaire containing demographic information, self-report anthropometric measurements, and validated scales. Artificial Intelligence Attitude Scale, Ecological Footprint Awareness Scale, Carbon Footprint Awareness Scale, and Mediterranean Diet Adherence Scale (MEDAS) were used in the study. RESULTS: Of the participants, 76.7% were female and 23.3% were male. Participants with adequate MD adherence (MEDAS >/= 7) were older, had higher BMI, and demonstrated higher ecological and carbon footprint awareness than those with lower adherence. AIAS-4 scores were similar between the MD adherence groups despite a weak negative correlation between AI attitudes and MEDAS scores (rho = -0.057, p = 0.037). AI attitudes were positively correlated with ecological (rho = 0.091, p < 0.001) and carbon footprint awareness (rho= 0.058, p = 0.032). In the multivariable linear regression model, ecological footprint awareness was independently associated with age (B = 0.229, p < 0.001), AIAS-4 (B = 1.151, p < 0.001), carbon footprint awareness (B = 1.331, p < 0.001), and male gender (B = - 4.186, p = 0.002), whereas MD adherence, education level, and AI use frequency were not significant predictors. The model explained 31.0% of the variance in ecological footprint awareness (R(2) = 0.310, p < 0.001). CONCLUSIONS: Positive attitudes toward artificial intelligence were associated with greater ecological and carbon footprint awareness but with slightly lower adherence to the Mediterranean diet. In contrast, greater adherence to the Mediterranean diet was positively associated with environmental footprint awareness. Carbon footprint awareness emerged as the strongest independent predictor of ecological footprint awareness. These findings provide preliminary evidence that attitudes toward artificial intelligence, dietary behavior, and environmental sustainability awareness are interrelated, although the observed associations were generally small and should be interpreted cautiously. CI - (c) 2026. The Author(s). FAU - Arslan, Neslihan AU - Arslan N AUID- ORCID: 0000-0002-1232-8009 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Faculty, University of Health Sciences, Ankara, Turkey. akdeniz.neslihan91@gmail.com. FAU - Celik, Ozge Mengi AU - Celik OM AUID- ORCID: 0000-0002-0298-9591 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Faculty, University of Health Sciences, Ankara, Turkey. FAU - Guler, Ummugulsum AU - Guler U AUID- ORCID: 0009-0001-3352-6047 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkey. FAU - Ekici, Emine Merve AU - Ekici EM AUID- ORCID: 0000-0001-5409-6309 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Faculty, University of Health Sciences, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260813 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Male MH - Cross-Sectional Studies MH - Middle Aged MH - Female MH - *Diet, Mediterranean/statistics & numerical data/psychology MH - Adult MH - *Artificial Intelligence MH - Turkey MH - Adolescent MH - Aged MH - Young Adult MH - *Carbon Footprint/statistics & numerical data MH - Surveys and Questionnaires MH - *Patient Compliance/statistics & numerical data/psychology PMC - PMC13628745 OTO - NOTNLM OT - Artificial intelligence OT - Carbon footprint OT - Ecological footprint OT - Mediterranean diet COIS- Declarations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was conducted with the approval of the University of Health Sciences Gulhane Scientific Research Ethics Committee, numbered 2025/357. Informed consent was obtained from all participants included in the study EDAT- 2026/10/02 05:31 MHDA- 2026/10/02 05:32 PMCR- 2026/08/13 CRDT- 2026/10/02 00:38 PHST- 2026/04/13 00:00 [received] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/10/02 05:32 [medline] PHST- 2026/10/02 05:31 [pubmed] PHST- 2026/10/02 00:38 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - 10.1186/s12889-026-28997-4 [pii] AID - 28997 [pii] AID - 10.1186/s12889-026-28997-4 [doi] PST - epublish SO - BMC Public Health. 2026 Aug 13;26(1):2730. doi: 10.1186/s12889-026-28997-4. PMID- 42823673 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261003 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Aug 3 TI - Mothers' perceptions and decision-making regarding tandem breastfeeding in Turkiye: a child health-focused qualitative study. LID - 10.1186/s12884-026-09764-0 [doi] LID - 1096 AB - BACKGROUND: Tandem breastfeeding, defined as breastfeeding two non-twin children during the same period, remains an underexplored practice in maternal and child health. Although it may be perceived as a way of maintaining breastfeeding continuity and emotional closeness with the older child, mothers may also encounter physical, emotional, practical, social and professional challenges. This study aimed to explore mothers' perceptions of tandem breastfeeding in Turkiye and to examine how these perceptions are shaped by emotional, socio-cultural, practical and healthcare-related factors. METHODS: A qualitative study design based on reflexive thematic analysis was used. Semi-structured, in-depth interviews were conducted with 21 mothers who had at least one child aged 0-2 years and were familiar with the concept of tandem breastfeeding. Mothers were recruited using purposive and snowball sampling. Current or previous direct tandem breastfeeding experience was not systematically recorded as a mother characteristic. Interviews were audio-recorded, transcribed verbatim and analysed inductively using MAXQDA 24. The study was reported in accordance with the COREQ checklist. RESULTS: Four main themes were identified: the perceived meaning of tandem breastfeeding, the perceived burden of tandem breastfeeding, social perceptions, and limited professional support. Mothers associated tandem breastfeeding with maintaining the mother-child bond, preventing abrupt weaning of the older child, and supporting a sense of fairness between siblings. They also perceived it as potentially involving physical fatigue, sleep deprivation, emotional ambivalence, increased care demands, and uncertainty regarding practical feasibility. Social norms, family attitudes, misconceptions, and limited access to evidence-based professional guidance influenced mothers' decision-making. Because direct tandem breastfeeding experience was not systematically recorded, the findings represent a combination of perceptions, beliefs, observed examples, anticipated concerns, and decision-making considerations rather than the confirmed lived experiences of a clearly defined group of tandem breastfeeding mothers. CONCLUSIONS: Tandem breastfeeding was perceived as a complex maternal and child health practice shaped by emotional, practical, socio-cultural, and healthcare-related factors. The findings provide insight into how mothers understand and evaluate tandem breastfeeding and how they approach decisions about whether to initiate or continue the practice. However, because mothers with confirmed direct tandem breastfeeding experience could not be distinguished from those expressing perceptions, expectations, or observed experiences, the findings should not be interpreted as evidence of the lived experience, feasibility, safety, or clinical outcomes of tandem breastfeeding. Further research involving clearly identified mothers with direct tandem breastfeeding experience is needed. CI - (c) 2026. The Author(s). FAU - Aslan, Meltem AU - Aslan M AUID- ORCID: 0000-0003-3847-2233 AD - Department of Midwifery, Faculty of Health Sciences, Istanbul Esenyurt University, Istanbul, Turkiye. meltemaslan@esenyurt.edu.tr. FAU - Say, Cemile AU - Say C AUID- ORCID: 0009-0007-5717-6962 AD - Department of Midwifery, Faculty of Health Sciences, Istanbul Esenyurt University, Istanbul, Turkiye. FAU - Navruz, Hilal Ezgi AU - Navruz HE AUID- ORCID: 0009-0009-9831-6604 AD - Department of Midwifery, Faculty of Health Sciences, Istanbul Esenyurt University, Istanbul, Turkiye. FAU - Nigiz, Simal AU - Nigiz S AUID- ORCID: 0009-0000-7921-7744 AD - Department of Nursing, Faculty of Health Sciences, Istanbul Esenyurt University, Istanbul, Turkiye. FAU - Kuroglu, Zeliha Ozge AU - Kuroglu ZO AUID- ORCID: 0009-0002-3104-0841 AD - Department of Midwifery, Faculty of Health Sciences, Istanbul Esenyurt University, Istanbul, Turkiye. LA - eng PT - Journal Article DEP - 20260803 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - *Breast Feeding/psychology MH - Female MH - Qualitative Research MH - Adult MH - *Mothers/psychology MH - *Decision Making MH - Infant MH - Infant, Newborn MH - Mother-Child Relations/psychology MH - Health Knowledge, Attitudes, Practice MH - Child, Preschool MH - Young Adult MH - Child Health PMC - PMC13629073 OTO - NOTNLM OT - Breastfeeding OT - Child health OT - Motherhood OT - Qualitative research OT - Tandem breastfeeding COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Istanbul Gelisim University Ethics Committee (Decision No: 2025-06-12), and the study was conducted in accordance with the Declaration of Helsinki. Written informed consent to participate was obtained from all participants prior to data collection, including consent for audio recording of the interviews. Participation was voluntary, and participants were informed of their right to withdraw from the study at any time without consequence. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/10/02 05:31 MHDA- 2026/10/02 05:32 PMCR- 2026/08/03 CRDT- 2026/10/02 00:37 PHST- 2026/04/25 00:00 [received] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/10/02 05:32 [medline] PHST- 2026/10/02 05:31 [pubmed] PHST- 2026/10/02 00:37 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.1186/s12884-026-09764-0 [pii] AID - 9764 [pii] AID - 10.1186/s12884-026-09764-0 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Aug 3;26(1):1096. doi: 10.1186/s12884-026-09764-0. PMID- 42821542 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261001 LR - 20261003 IS - 2767-3375 (Electronic) IS - 2767-3375 (Linking) VI - 6 IP - 10 DP - 2026 TI - Rapid diagnosis of pulmonary tuberculosis on induced sputum in children in a high burden setting for HIV and malnutrition. PG - e0007271 LID - 10.1371/journal.pgph.0007271 [doi] LID - e0007271 AB - Microbiological diagnosis of childhood pulmonary tuberculosis can be challenging. We investigated the accuracy of Xpert MTB/RIF Ultra on the induced sputum, focused on high-risk groups (infants, malnourished children, and those living with HIV), where data is limited. Children (under 15 years) investigated for pulmonary tuberculosis at Dora Nginza Hospital, South Africa, were prospectively enrolled between January 2018 and January 2024, and followed up for 12 months. Induced sputa were tested with liquid culture and Xpert MTB/RIF Ultra (Ultra). Children were categorized with confirmed, unconfirmed, or unlikely tuberculosis, according to NIH consensus definitions. Ultra diagnostic accuracy was calculated against culture, with analysis by high-risk subgroups. Of 636 children (median age, 27.4 (IQR 11.8-61.6) months), 173 (27.2%) were classified with confirmed TB, 384 (60.4%) with unconfirmed TB, and 79 (12.4%) with unlikely TB. There were 223 (37.8%) children underweight-for-age, 168 (26.5%) living with HIV, and 163 (25.6%) infants. Of 557 children with TB, 145 (26.0%) were confirmed on induced sputa; with 137/557 (24.6%) confirmed on Ultra (46.0%; 63/137, of which were "trace positive"), and 88/557 (15.8%), on culture. Of those confirmed, 57/145 (39.3%) were Ultra positive, culture negative - contributing 10.2% to the overall yield. Ultra performed better in children over 5 years and with weight-for-height Z-scores < -3. Overall, Ultra sensitivity was 90.9% (95%CI 82.9-96.0) and specificity, 89.6% (95%CI 86.7-92.0), with high accuracy across high-risk groups. Mortality amongst children treated for PTB was 4.9% (27/557) with aRR highest for stunted children (7.3; 95% CI, 2.2-24.2), followed by children with HIV (3.5; 95% CI, 1.6-7.5), and infants (3.3; 95% CI, 1.6-6.7). Ultra on induced sputum was feasible, with high yield and diagnostic accuracy for high-risk children. CI - Copyright: (c) 2026 Luiz et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Luiz, Juaneta AU - Luiz J AUID- ORCID: 0009-0005-7921-8129 AD - Department of Paediatrics and Child Health, University of Cape Town, and South African Medical Research Council Unit on Child & Adolescent Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa. AD - Department of Paediatrics, Dora Nginza Hospital, Gqeberha, South Africa. FAU - Workman, Lesley J AU - Workman LJ AUID- ORCID: 0000-0002-3433-6106 AD - Department of Paediatrics and Child Health, University of Cape Town, and South African Medical Research Council Unit on Child & Adolescent Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa. FAU - Baard, Cynthia B AU - Baard CB AUID- ORCID: 0000-0002-4747-7610 AD - Department of Paediatrics and Child Health, University of Cape Town, and South African Medical Research Council Unit on Child & Adolescent Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa. FAU - Hlombe, Yekiwe AU - Hlombe Y AD - Department of Paediatrics and Child Health, University of Cape Town, and South African Medical Research Council Unit on Child & Adolescent Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa. AD - Department of Paediatrics, Dora Nginza Hospital, Gqeberha, South Africa. FAU - Prins, Margaretha AU - Prins M AUID- ORCID: 0009-0001-9755-9614 AD - Department of Paediatrics and Child Health, University of Cape Town, and South African Medical Research Council Unit on Child & Adolescent Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa. FAU - Makubalo, Nomlindo AU - Makubalo N AD - Department of Paediatrics, Dora Nginza Hospital, Gqeberha, South Africa. FAU - Jaganath, Devan AU - Jaganath D AD - Division of Pediatric Infectious Diseases, University of California San Francisco, San Francisco, United States of America. AD - Center for Tuberculosis, Institute for Global Health Sciences, University of California San Francisco, San Francisco, United States of America. FAU - Cattamanchi, Adithya AU - Cattamanchi A AUID- ORCID: 0000-0002-6553-2601 AD - Center for Tuberculosis, Institute for Global Health Sciences, University of California San Francisco, San Francisco, United States of America. AD - Division of Pulmonary Diseases and Critical Care Medicine, University of California Irvine, Irvine, United States of America. FAU - Nicol, Mark P AU - Nicol MP AD - Division of Medical Microbiology and Institute for Infectious Diseases and Molecular Medicine, University of Cape Town and National Health Laboratory Services, Cape Town, South Africa. AD - Marshall Centre, School of Biomedical Sciences, University of Western Australia, Perth, Australia. FAU - Zar, Heather J AU - Zar HJ AD - Department of Paediatrics and Child Health, University of Cape Town, and South African Medical Research Council Unit on Child & Adolescent Health, Red Cross War Memorial Children's Hospital, Cape Town, South Africa. LA - eng GR - R01 AI152161/AI/NIAID NIH HHS/United States PT - Journal Article DEP - 20261001 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC13630226 COIS- I have read the journal's policy and the authors of this manuscript have the following competing interests: DJ serves on the editorial board of PLOS Global Public Health. This did not alter the author's adherence to all PLOS Global Public Health policies on data and material sharing, and DJ was not involved in the peer review or editorial decision-making process for this manuscript. The remaining authors (JL, LJW, CBB, YH, MP, NM, AC, MPN, and HJZ) have declared that no competing interests exist. EDAT- 2026/10/02 03:09 MHDA- 2026/10/02 03:10 PMCR- 2026/10/01 CRDT- 2026/10/01 19:20 PHST- 2026/02/04 00:00 [received] PHST- 2026/08/20 00:00 [accepted] PHST- 2026/10/02 03:10 [medline] PHST- 2026/10/02 03:09 [pubmed] PHST- 2026/10/01 19:20 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - PGPH-D-26-00364 [pii] AID - 10.1371/journal.pgph.0007271 [doi] PST - epublish SO - PLOS Glob Public Health. 2026 Oct 1;6(10):e0007271. doi: 10.1371/journal.pgph.0007271. eCollection 2026. PMID- 42819986 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261001 LR - 20261001 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - The "pro-inflammatory imprint" of ultra-processed food exposure: a review of mechanisms affecting child and adolescent health and development via the gut microbiome-inflammation axis. PG - 1843587 LID - 10.3389/fnut.2026.1843587 [doi] LID - 1843587 AB - The prevalence of ultra-processed food (UPF) consumption in pediatric diets has raised significant concerns regarding long-term health. This review examines evidence for a proposed 'pro-inflammatory imprint' involving the gut microbiome-inflammation axis. Using a structured narrative synthesis of pediatric observational evidence, adult intervention studies, preclinical research, multi-omics data, and public health evaluations, we examine associations between UPF exposure and metabolic, inflammatory, cognitive, and neurodevelopmental outcomes while distinguishing direct from indirect evidence. We propose the Pediatric-Specific Integrated Dietary Inflammatory Index (cP-IDII) as an unvalidated, hypothesis-generating research framework for integrating reproducible nutrient- and processing-related dietary exposures; downstream microbial, intestinal-barrier, inflammatory, metabolic, and immune measures are reserved for external validation. Furthermore, we discuss the role of commercial determinants and environmental factors in shaping child health. The synthesis identifies measurement gaps and complementary policy entry points across product composition, food environments, affordability, and marketing. Empirical development and external validation are required before the cP-IDII can be used for clinical, epidemiological, or public health decision-making. CI - Copyright (c) 2026 Liu, Luo, Yan, Yang, Long, Yang, He and Tao. FAU - Liu, Qinghua AU - Liu Q AD - College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China. FAU - Luo, Lijiao AU - Luo L AD - College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China. FAU - Yan, Zhiwen AU - Yan Z AD - Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Yang, Pan AU - Yang P AD - Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Long, Teng AU - Long T AD - Department of Clinical Nutrition, People's Hospital of Chongqing, Hechuan, Chongqing, China. FAU - Yang, Yuntao AU - Yang Y AD - Department of Clinical Nutrition, People's Hospital of Chongqing, Hechuan, Chongqing, China. FAU - He, Min AU - He M AD - Department of Clinical Nutrition, People's Hospital of Chongqing, Hechuan, Chongqing, China. FAU - Tao, Li AU - Tao L AD - Department of Clinical Nutrition, People's Hospital of Chongqing, Hechuan, Chongqing, China. LA - eng PT - Journal Article PT - Review DEP - 20260916 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13625691 OTO - NOTNLM OT - Dietary Inflammatory Index (DII) OT - childhood obesity OT - food environment OT - gut-brain axis OT - metabolic programming OT - neurodevelopment OT - ultra-processed foods COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/02 03:09 MHDA- 2026/10/02 03:10 PMCR- 2026/09/16 CRDT- 2026/10/01 17:31 PHST- 2026/03/31 00:00 [received] PHST- 2026/07/29 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/02 03:10 [medline] PHST- 2026/10/02 03:09 [pubmed] PHST- 2026/10/01 17:31 [entrez] PHST- 2026/09/16 00:00 [pmc-release] AID - 10.3389/fnut.2026.1843587 [doi] PST - epublish SO - Front Nutr. 2026 Sep 16;13:1843587. doi: 10.3389/fnut.2026.1843587. eCollection 2026. PMID- 42823283 OWN - NLM STAT- Publisher LR - 20261001 IS - 1879-730X (Electronic) IS - 1879-7296 (Linking) DP - 2026 Oct 1 TI - A pilot feasibility study of awake laryngeal ultrasonography in children. LID - S1879-7296(26)00180-8 [pii] LID - 10.1016/j.anorl.2026.09.004 [doi] AB - BACKGROUND: Flexible nasal laryngoscopy is the gold standard examination for laryngeal assessment, but can be uncomfortable, poorly tolerated or even refused by children. Ultrasonography is non-invasive and well-tolerated and could provide an alternative. Data in children, however, are scarce. AIMS: To assess the feasibility of in-office ultrasonography in children for the identification of laryngeal structures using reference imaging planes, and to determine factors influencing examination quality. MATERIAL AND METHODS: A single-center non-interventional prospective pilot feasibility study of a diagnostic tool was conducted in children aged 0 to 15 years. Ultrasonographic images were evaluated by the performing operator and by a second blinded observer using recorded sequences. Qualitative data and inter-rater agreement were expressed as percentages. Association was assessed by logistic regression, with the significance threshold set at 1%. RESULTS: One hundred and forty children were included. The 5 ultrasound planes - axial glottic, subglottic and tracheal, and sagittal median and paramedian - allowed visualization of the thyroid, cricoid and arytenoid cartilage and vocal fold mobility in more than 95% of cases for both assessors. Age and gender effects differed between assessors, while BMI showed no significant effect. Calcification foci, without posterior acoustic shadowing, did not interfere with structural analysis. CONCLUSION: We demonstrated the feasibility of pediatric laryngeal ultrasonography using 5 reference planes, enabling visualization of laryngeal structures regardless of calcifications. CI - Copyright (c) 2026 Elsevier Masson SAS. All rights reserved. FAU - Shan, C AU - Shan C AD - Service d'oto-rhino-laryngologie et chirurgie cervico-faciale, centre hospitalo-universitaire de Bordeaux, Bordeaux, France. Electronic address: constancesh31@gmail.com. FAU - Sagardoy, T AU - Sagardoy T AD - Service d'oto-rhino-laryngologie et chirurgie cervico-faciale, centre hospitalo-universitaire de Bordeaux, Bordeaux, France. FAU - Soualhi, A AU - Soualhi A AD - Service d'oto-rhino-laryngologie et chirurgie cervico-faciale, centre hospitalo-universitaire de Bordeaux, Bordeaux, France. LA - eng PT - Journal Article DEP - 20261001 PL - France TA - Eur Ann Otorhinolaryngol Head Neck Dis JT - European annals of otorhinolaryngology, head and neck diseases JID - 101531465 SB - IM OTO - NOTNLM OT - Flexible nasal laryngoscopy OT - Laryngeal ultrasound OT - Pediatric ENT OT - Pediatrics COIS- Disclosure of interest The authors declare that they have no competing interest. EDAT- 2026/10/01 23:30 MHDA- 2026/10/01 23:30 CRDT- 2026/10/01 22:03 PHST- 2026/10/01 23:30 [medline] PHST- 2026/10/01 23:30 [pubmed] PHST- 2026/10/01 22:03 [entrez] AID - S1879-7296(26)00180-8 [pii] AID - 10.1016/j.anorl.2026.09.004 [doi] PST - aheadofprint SO - Eur Ann Otorhinolaryngol Head Neck Dis. 2026 Oct 1:S1879-7296(26)00180-8. doi: 10.1016/j.anorl.2026.09.004. PMID- 42819193 OWN - NLM STAT- Publisher LR - 20261001 IS - 2589-0514 (Electronic) IS - 2095-882X (Print) IS - 2095-882X (Linking) DP - 2026 Sep 30 TI - Prediction of Prevalent Cardiovascular Disease Using Social, Environmental, and Behavioral Factors: A Vital Conditions Framework Approach. LID - 10.1002/cdt3.70069 [doi] AB - BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death in the United States. We examined whether a model that classifies prevalent CVD using clinical risk factor precursors (social, environmental, and behavioral factors), age, and sex, organized according to the Vital Conditions for Health framework, demonstrates good discrimination and calibration. METHODS: In this cross-sectional study, we analyzed the 2021 Medical Expenditure Panel Survey (MEPS) Social Determinants of Health (SDOH) dataset (N = 18,435 adults). Cardiovascular disease prevalence was defined using self-reported diagnoses and International Classification of Diseases, 10th Revision (ICD-10), codes. Candidate predictors included variables from the seven Vital Conditions domains, age, and sex. Models included least absolute shrinkage and selection operator (LASSO) regression and extreme gradient boosting (XGBoost). Internal validation used stratified k-fold cross-validation and 2022 MEPS data. Discrimination and calibration were assessed using the area under the receiver operating characteristic curve (AUC), Brier score, calibration slope, calibration-in-the-large (CITL), and observed-to-expected (O:E) ratio. Subgroup performance was evaluated by age, sex, and race or ethnicity. RESULTS: Both LASSO and XGBoost performed well. LASSO achieved an AUC of 0.822 (95% confidence interval [CI], 0.815-0.831), with a calibration slope of 1.022 and an O:E ratio of 1.001. XGBoost achieved an AUC of 0.822 (95% CI, 0.814-0.831), with a calibration slope of 1.026 and an O:E ratio of 1.002. Discrimination was stable across sex and race or ethnicity subgroups, although some calibration drift occurred among Hispanic participants. Performance declined among adults aged >/= 65 years (XGBoost AUC, 0.67) compared with those aged < 65 years (AUC, 0.812). Key predictors included age, sex, exercise, social isolation, healthcare access, food insecurity, financial strain, adverse childhood experiences (ACEs), smoking, and transportation barriers. CONCLUSIONS: Models using upstream social determinants of health, age, and sex demonstrated good discrimination when classifying prevalent CVD. External and prospective validation is needed before these models can be considered for clinical or population-level screening. CI - (c) 2026 The Author(s). Chronic Diseases and Translational Medicine published by John Wiley & Sons Ltd on behalf of Chinese Medical Association. FAU - Kjelstrom, Stephanie AU - Kjelstrom S AUID- ORCID: 0000-0003-0933-4472 AD - College of Population Health Thomas Jefferson University Philadelphia Pennsylvania USA. AD - Lankenau Institute for Medical Research Wynnewood Pennsylvania USA. FAU - Hass, Richard AU - Hass R AD - College of Population Health Thomas Jefferson University Philadelphia Pennsylvania USA. FAU - Vollbrecht, Robert AU - Vollbrecht R AD - Brown University Providence Rhode Island USA. FAU - George, Brandon AU - George B AD - College of Population Health Thomas Jefferson University Philadelphia Pennsylvania USA. FAU - Larson, Sharon AU - Larson S AD - College of Population Health Thomas Jefferson University Philadelphia Pennsylvania USA. LA - eng PT - Journal Article DEP - 20260930 PL - United States TA - Chronic Dis Transl Med JT - Chronic diseases and translational medicine JID - 101679934 PMC - PMC13625146 OTO - NOTNLM OT - cardiovascular diseases OT - prediction algorithms OT - risk OT - social determinants of health COIS- The authors declare no conflicts of interest. EDAT- 2026/10/01 17:29 MHDA- 2026/10/01 17:29 PMCR- 2026/09/30 CRDT- 2026/10/01 14:15 PHST- 2026/01/05 00:00 [received] PHST- 2026/08/18 00:00 [revised] PHST- 2026/09/11 00:00 [accepted] PHST- 2026/10/01 17:29 [medline] PHST- 2026/10/01 17:29 [pubmed] PHST- 2026/10/01 14:15 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - CDT370069 [pii] AID - 10.1002/cdt3.70069 [doi] PST - aheadofprint SO - Chronic Dis Transl Med. 2026 Sep 30:10.1002/cdt3.70069. doi: 10.1002/cdt3.70069. PMID- 42818738 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261001 LR - 20261002 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Body roundness index and adolescent metabolic syndrome: dose-response analysis and serum biomarker mediation. PG - 1930822 LID - 10.3389/fnut.2026.1930822 [doi] LID - 1930822 AB - BACKGROUND: The Body Roundness Index (BRI) combines waist circumference and height into a single geometric measure that is intended to reflect visceral adiposity. Its ability to predict metabolic syndrome (MetS) in adolescents and the biological processes that mediate this association have not been well defined. We tested the BRI-MetS relationship in Chinese adolescents, compared BRI with body mass index (BMI), and examined whether circulating biomarkers mediated this association. METHODS: This cross-sectional study recruited 914 Chinese adolescents (53.2% boys) aged 11-16 years. MetS was defined according to Chinese pediatric guidelines (CN2025) and the International Diabetes Federation (IDF) criteria. Associations and predictive performance were assessed using logistic regression, restricted cubic splines (RCS), and receiver operating characteristic (ROC) curves. Subgroup analyses were stratified by sex and BMI category. Potential mechanistic pathways involving 22 serum biomarkers were investigated by correlation networks, hierarchical clustering, and two-stage mediation models. RESULTS: BRI was positively associated with MetS (CN2025: OR = 3.63 per unit, 95%CI 2.91-4.53; IDF: OR = 2.64, 95%CI 2.14-3.26). RCS demonstrated non-linear dose-response relationship, with an acceleration in risk beyond BRI of approximately 4.0. BRI outperformed BMI in discriminating MetS (AUC 0.873 vs. 0.835, p = 0.005), especially among normal-weight participants (OR = 3.48, p < 0.001). Sex stratification showed that BRI was associated with hypertriglyceridemia and hypertension in male adolescents (p < 0.001) but not in female adolescents. We identified three biomarker co-expression modules: the upward module (ALT, FINS, and UA) mediated 52.9% of the association between BRI and hypertriglyceridemia and 54.1-59.5% of the association between BRI and hypertension; SFRP5 and irisin mediated the associations of BRI with fasting plasma glucose (FPG) and HDL-cholesterol, respectively. CONCLUSION: BRI may be a better predictor of MetS in Chinese adolescents, particularly when MetS is defined using domestic criteria. Its predictive power was greatest among normal-weight adolescents and varied by sex. Exploratory mediation analyses identified the metabolic-inflammatory axis and protective adipokines as key mediators, suggesting hypothesis-generating targets for interventions to improve adolescent metabolic health that require longitudinal validation. CI - Copyright (c) 2026 Yao, Wang, Zhou, Wang, Wang and Du. FAU - Yao, Hui AU - Yao H AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Wang, Yiwen AU - Wang Y AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Zhou, Fang AU - Zhou F AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Wang, Fei AU - Wang F AD - Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Wang, Xiaochen AU - Wang X AD - Department of Endocrinology, Liaoning Provincial People's Hospital, Shenyang, China. FAU - Du, Runyu AU - Du R AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. LA - eng PT - Journal Article DEP - 20260916 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13623853 OTO - NOTNLM OT - adipokine OT - adolescent OT - body roundness index OT - dose-response analysis OT - mediation analysis OT - metabolic syndrome OT - restricted cubic spline COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/01 11:37 MHDA- 2026/10/01 11:38 PMCR- 2026/09/16 CRDT- 2026/10/01 10:15 PHST- 2026/07/07 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/30 00:00 [accepted] PHST- 2026/10/01 11:38 [medline] PHST- 2026/10/01 11:37 [pubmed] PHST- 2026/10/01 10:15 [entrez] PHST- 2026/09/16 00:00 [pmc-release] AID - 10.3389/fnut.2026.1930822 [doi] PST - epublish SO - Front Nutr. 2026 Sep 16;13:1930822. doi: 10.3389/fnut.2026.1930822. eCollection 2026. PMID- 42818614 OWN - NLM STAT- MEDLINE DCOM- 20261001 LR - 20261027 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Association rule analysis of food-specific IgG and clinical symptoms in pediatric patients. PG - 1940230 LID - 10.3389/fimmu.2026.1940230 [doi] LID - 1940230 AB - Food-specific immunoglobulin G (IgG) have drawn increasing attention in pediatric food intolerance study, yet population-based data and their associations with clinical symptoms remain limited. This retrospective study included 100 children (56 males, 44 females; age groups: <5 years, n=20; 5-9 years, n=50; >/=10 years, n=30) from Zhuhai, China. Serum specific IgG against 14 common foods were measured by enzyme-linked immunosorbent assay (ELISA) and classified as negative (<50 U/mL), mild (50-100 U/mL), moderate (100-200 U/mL), or severe (>/=200 U/mL). Spearman correlation and Apriori association rule analysis (minimum support 6%, minimum confidence 50%, lift >1.5) were applied. The three most prevalent food-specific IgG positivities were egg (89.0%), milk (73.0%), and wheat (48.0%). Total positivity rate of each food correlated positively with its severe proportion (r=0.8733, P<0.001). No significant differences between sex were found in positivity rates, but the correlation patterns differed. In boys, both moderate and severe proportions correlated with positivity rates, while in girls, only the severe proportion did. Age showed no significant effect on positivity rates, though food-specific IgG response intensity trend to decrease with age. The four most frequent clinical symptoms were cough-related (25 cases), nasal diseases (20 cases), tic disorder/chronic tic disorders (19 cases), and deficiency-excess complex pattern (9 cases). Association rule mining identified four strong rules; the strongest was deficiency-excess complex pattern with egg and milk co-positivity (support 7.0%, confidence 77.8%, lift 6.09). These findings suggest that egg, milk, and wheat are the predominant IgG‑positive food items in this cohort. The positive correlation between positivity rate and severe proportion, along with the strong association between deficiency-excess complex pattern and egg-milk co-positivity, may inform dietary interventions in children with food intolerance, though prospective validation is warranted. CI - Copyright (c) 2026 Zhou, Wu and Qiao. FAU - Zhou, Zidong AU - Zhou Z AD - YunKang School of Medicine and Health, Nanfang College Guangzhou, Guangzhou, Guangdong, China. AD - Department of Clinical Laboratory, Zhuhai Hospital of Traditional Chinese Medicine, Zhuhai, Guangdong, China. FAU - Wu, Hongqiu AU - Wu H AD - Department of Clinical Laboratory, Zhuhai Hospital of Traditional Chinese Medicine, Zhuhai, Guangdong, China. FAU - Qiao, Xifeng AU - Qiao X AD - YunKang School of Medicine and Health, Nanfang College Guangzhou, Guangzhou, Guangdong, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260916 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Immunoglobulin G) RN - 0 (Allergens) SB - IM MH - Humans MH - Female MH - Male MH - *Immunoglobulin G/blood/immunology MH - Child, Preschool MH - Child MH - *Food Hypersensitivity/immunology/diagnosis/blood/epidemiology MH - Retrospective Studies MH - China/epidemiology MH - Allergens/immunology PMC - PMC13623606 OTO - NOTNLM OT - association rule mining OT - children OT - clinical symptoms OT - food intolerance OT - food-specific IgG COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/10/01 11:37 MHDA- 2026/10/01 11:38 PMCR- 2026/09/16 CRDT- 2026/10/01 08:37 PHST- 2026/07/17 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/01 11:38 [medline] PHST- 2026/10/01 11:37 [pubmed] PHST- 2026/10/01 08:37 [entrez] PHST- 2026/09/16 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1940230 [doi] PST - epublish SO - Front Immunol. 2026 Sep 16;17:1940230. doi: 10.3389/fimmu.2026.1940230. eCollection 2026. PMID- 42817819 OWN - NLM STAT- Publisher LR - 20261001 IS - 1467-1107 (Electronic) IS - 1047-9511 (Linking) DP - 2026 Oct 1 TI - The grey zone before pulmonary valve replacement in repaired tetralogy of Fallot: a paediatric perspective on the 2024 American Heart Association scientific statement. PG - 1-4 LID - 10.1017/S1047951126124202 [doi] AB - The 2024 American Heart Association scientific statement broadened risk assessment in repaired tetralogy of Fallot beyond right ventricular volume, bringing together ejection fraction, exercise capacity, pressure load, and a validated risk score. One group of patients remains difficult: those whose right ventricular volumes are borderline and who meet no threshold for intervention. We describe this borderline range as a grey zone, with an indexed end-diastolic volume of approximately 140 to 160 mL/m(2) and an indexed end-systolic volume of approximately 70 to 80 mL/m(2). Within this range, no single value decides the timing of pulmonary valve replacement, and the direction of change across serial studies carries more information than any single borderline result. We outline a structured approach that places volume alongside markers of ventricular function, exercise capacity, the rhythm substrate, tissue characterisation, and loading conditions, in order to estimate the risk of continued surveillance and to set the interval to the next review. We also note that the imaging methods underlying this framework are unevenly available and unevenly taught across centres, drawing on a recent survey from the Association for European Paediatric and Congenital Cardiology, and that a framework intended for diverse centres is most useful when it separates assessments available to every unit from those available only to some. We present this framework as a way to structure reasoning at the bedside and to seed prospective multicentre study of borderline patients, rather than as a new set of cut-offs. FAU - Ulug Murt, Nujin AU - Ulug Murt N AUID- ORCID: 0000-0003-3748-8671 AD - Department of Paediatric Cardiology, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. ROR: https://ror.org/03qweed85 FAU - Ramcharan, Tristan AU - Ramcharan T AUID- ORCID: 0000-0003-0197-0722 AD - Department of Paediatric Cardiology, Birmingham Children's Hospital, Birmingham, UK. AD - Cardiovascular Clinical Academic Group, City St George's, University of London, London, UK. LA - eng PT - Journal Article DEP - 20261001 PL - England TA - Cardiol Young JT - Cardiology in the young JID - 9200019 SB - IM OTO - NOTNLM OT - Tetralogy of Fallot OT - cardiovascular magnetic resonance OT - multimodality imaging OT - pulmonary valve replacement OT - right ventricular function EDAT- 2026/10/01 05:31 MHDA- 2026/10/01 05:31 CRDT- 2026/10/01 04:22 PHST- 2026/10/01 05:31 [medline] PHST- 2026/10/01 05:31 [pubmed] PHST- 2026/10/01 04:22 [entrez] AID - S1047951126124202 [pii] AID - 10.1017/S1047951126124202 [doi] PST - aheadofprint SO - Cardiol Young. 2026 Oct 1:1-4. doi: 10.1017/S1047951126124202. PMID- 42817767 OWN - NLM STAT- MEDLINE DCOM- 20261001 LR - 20261027 IS - 1099-0496 (Electronic) IS - 8755-6863 (Print) IS - 1099-0496 (Linking) VI - 61 IP - 10 DP - 2026 Oct TI - Test-Retest Reliability, Learning Effect and Measurement Error of the Modified Shuttle Test (MST) in Children With Asthma: A Multicenter Study. PG - e71852 LID - e71852 [pii] LID - 10.1002/ppul.71852 [doi] AB - OBJECTIVE: To investigate test-retest reliability, measurement error (standard error of measurement [SEM] and minimum detectable difference [MDD]), and the learning effect of the Modified Shuttle Test (MST) in children with asthma. METHODS: Multicenter cross-sectional study including clinically stable children aged 6-12 years with asthma. Lung function and exercise capacity were assessed using MST. Intraclass Correlation Coefficient (ICC) was calculated to assess test-retest reliability. The first and second tests were compared using the paired Student's t-test to assess differences between tests. SEM and MDD were calculated to quantify measurement error. RESULTS: One hundred and twenty three children were included (71 boys [57%]; median age 9 [7-10] years). The mean distance covered in the best MST was 611 +/- 214 meters (confidence interval [95% CI] = 573-649meters). The MST showed an excellent test-retest reliability (ICC = 0.96; 95% CI: 0.95-0.97). Distance was significantly lower in the second test than in the first (574 +/- 218 vs. 601 +/- 216 m; p = 0.0001). Learning effect was -27 +/- 79 (4% +/- 14%), the SEM was 56 meters (9.5%), and the MDD was 156 m (26.6%). CONCLUSION: The MST demonstrated excellent test-retest reliability and acceptable measurement error for assessing exercise capacity in children with asthma. Although a systematic difference was observed between tests, there was no evidence of a consistent learning effect, with individual variability in repeated performance. CI - (c) 2026 The Author(s). Pediatric Pulmonology published by Wiley Periodicals LLC. FAU - Radis, Lara Bezerra AU - Radis LB AUID- ORCID: 0009-0001-1333-9762 AD - Associated Graduate Program (MSc and PhD) in Rehabilitation Sciences at State University of Londrina (UEL) and University Pitagoras UNOPAR (UNOPAR), Londrina, Parana, Brazil. FAU - Puzzi, Vitoria Cavalheiro AU - Puzzi VC AUID- ORCID: 0000-0002-3696-056X AD - Associated Graduate Program (MSc and PhD) in Rehabilitation Sciences at State University of Londrina (UEL) and University Pitagoras UNOPAR (UNOPAR), Londrina, Parana, Brazil. FAU - Dias, Thaila Corsi AU - Dias TC AUID- ORCID: 0009-0002-5897-4396 AD - Associated Graduate Program (MSc and PhD) in Rehabilitation Sciences at State University of Londrina (UEL) and University Pitagoras UNOPAR (UNOPAR), Londrina, Parana, Brazil. FAU - Correia, Natielly Soares AU - Correia NS AUID- ORCID: 0000-0002-4757-6651 AD - Associated Graduate Program (MSc and PhD) in Rehabilitation Sciences at State University of Londrina (UEL) and University Pitagoras UNOPAR (UNOPAR), Londrina, Parana, Brazil. FAU - Montes, Jessica Lane Felippe AU - Montes JLF AUID- ORCID: 0009-0000-6813-4345 AD - Associated Graduate Program (MSc and PhD) in Rehabilitation Sciences at State University of Londrina (UEL) and University Pitagoras UNOPAR (UNOPAR), Londrina, Parana, Brazil. FAU - Reimberg, Mariana Mazzuca AU - Reimberg MM AUID- ORCID: 0000-0002-1187-2782 AD - University Nove de Julho, UNINOVE, Sao Paulo, Sao Paulo, Brazil. FAU - Lanza, Fernanda Cordoba AU - Lanza FC AUID- ORCID: 0000-0002-4748-6947 AD - Department of Physical Therapy, Graduate Program in Rehabilitation Sciences, University Federal de Minas Gerais (UFMG), Belo Horizonte, Minas Gerais, Brazil. FAU - de Freitas Dantas Gomes, Evelim Leal AU - de Freitas Dantas Gomes EL AUID- ORCID: 0000-0002-0636-6041 AD - Graduate Program Science Rehabilitation, Universidade de Sao Paulo, Sao Paulo, Sao Paulo, Brazil. FAU - de Amorim, Claudio Luiz Castro Gomes AU - de Amorim CLCG AUID- ORCID: 0000-0001-7045-767X AD - Health Science Center, State University of Londrina (UEL), Londrina, Parana, Brazil. FAU - Furlanetto, Karina Couto AU - Furlanetto KC AUID- ORCID: 0000-0002-7496-7228 AD - Associated Graduate Program (MSc and PhD) in Rehabilitation Sciences at State University of Londrina (UEL) and University Pitagoras UNOPAR (UNOPAR), Londrina, Parana, Brazil. AD - Health Science Center, State University of Londrina (UEL), Londrina, Parana, Brazil. LA - eng PT - Journal Article PT - Multicenter Study PL - United States TA - Pediatr Pulmonol JT - Pediatric pulmonology JID - 8510590 SB - IM MH - Humans MH - Child MH - *Asthma/physiopathology/diagnosis MH - Reproducibility of Results MH - Cross-Sectional Studies MH - Male MH - Female MH - *Exercise Test/methods MH - *Exercise Tolerance/physiology PMC - PMC13628282 OTO - NOTNLM OT - asthma OT - exercise tolerance OT - pediatrics OT - reliability COIS- The authors declare no conflicts of interest. EDAT- 2026/10/01 05:31 MHDA- 2026/10/01 05:32 PMCR- 2026/10/01 CRDT- 2026/10/01 03:52 PHST- 2026/09/13 00:00 [revised] PHST- 2026/02/24 00:00 [received] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/10/01 05:32 [medline] PHST- 2026/10/01 05:31 [pubmed] PHST- 2026/10/01 03:52 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - e71852 [pii] AID - PPUL71852 [pii] AID - 10.1002/ppul.71852 [doi] PST - ppublish SO - Pediatr Pulmonol. 2026 Oct;61(10):e71852. doi: 10.1002/ppul.71852. PMID- 42815717 OWN - NLM STAT- Publisher LR - 20261027 IS - 2352-3840 (Electronic) IS - 1499-2671 (Linking) DP - 2026 Sep 30 TI - Comparing Physical Activity and Sedentary Time in Children and Adolescents With Type 1 Diabetes Using Different Accelerometer Data Processing Protocols. LID - S1499-2671(26)00368-0 [pii] LID - 10.1016/j.jcjd.2026.09.005 [doi] AB - OBJECTIVE: Regular physical activity (PA) is crucial for managing type 1 diabetes (T1D), yet many children fail to achieve the recommended 60 min of daily moderate-to-vigorous PA (MVPA). Device-based (accelerometry) measurement of PA and sedentary time (SED) may be influenced by analytical decisions (e.g. cut points), but less is known about these methodological effects in children with T1D. This study aims to 1) compare the effects of different accelerometer data processing protocols on PA and SED estimates and 2) evaluate how these variations influence the proportion of children with T1D meeting PA guidelines. METHODS: Participants aged 7 to 17 years with T1D (n=43; 49% female; 13.7+/-2.3 years) wore an ActiGraph accelerometer on their right hip for 7 days. ActiLife software processed data according to 8 published protocols to classify SED, light PA (LPA), and MVPA. Linear mixed-effects models compared activity time estimates across protocols, and Cochran's Q test assessed differences in the proportion meeting PA guidelines. RESULTS: SED, LPA, and MVPA estimates differed significantly across protocols (p<0.001), with mean daily SED ranging from 438 to 700 min, LPA from 82 to 329 min, and MVPA from 16 to 193 min. Protocol choice also influenced the proportion of participants meeting the MVPA guidelines (Q(7)=172.0, n=31, p<0.001), with some methods consistently classifying more participants as meeting recommendations than others. CONCLUSIONS: This study addresses gaps in accelerometer-based research by identifying protocol-specific variability in activity measurement in children with T1D. Without criterion reference measures, it remains unclear which protocols provide the most accurate estimates. Future research should incorporate validation methods to strengthen methodological decision-making. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Sedarous, Eden AU - Sedarous E AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. FAU - Letts, Elyse AU - Letts E AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. FAU - Byra, Madelyn M AU - Byra MM AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. FAU - Ball, Elizabeth AU - Ball E AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada. FAU - McAssey, Karen AU - McAssey K AD - Department of Pediatrics, McMaster Children's Hospital, McMaster University, Hamilton, Ontario, Canada. FAU - Timmons, Brian W AU - Timmons BW AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada. FAU - Obeid, Joyce AU - Obeid J AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Hamilton, Ontario, Canada; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada. Electronic address: obeidj@mcmaster.ca. LA - eng PT - Journal Article DEP - 20260930 PL - Canada TA - Can J Diabetes JT - Canadian journal of diabetes JID - 101148810 SB - IM OTO - NOTNLM OT - cut point OT - device-based measurement OT - moderate-to-vigorous physical activity OT - pediatric chronic disease OT - wear-time validation EDAT- 2026/09/30 23:30 MHDA- 2026/09/30 23:30 CRDT- 2026/09/30 19:32 PHST- 2026/05/20 00:00 [received] PHST- 2026/08/14 00:00 [revised] PHST- 2026/09/14 00:00 [accepted] PHST- 2026/09/30 23:30 [pubmed] PHST- 2026/09/30 23:30 [medline] PHST- 2026/09/30 19:32 [entrez] AID - S1499-2671(26)00368-0 [pii] AID - 10.1016/j.jcjd.2026.09.005 [doi] PST - aheadofprint SO - Can J Diabetes. 2026 Sep 30:S1499-2671(26)00368-0. doi: 10.1016/j.jcjd.2026.09.005. PMID- 42815641 OWN - NLM STAT- Publisher LR - 20261028 IS - 2156-5376 (Electronic) IS - 2161-8313 (Linking) VI - 17 IP - 11 DP - 2026 Sep 30 TI - Measuring Co-coverage in Global Health and Nutrition Interventions: A Scoping Review of Analytical Approaches. PG - 100742 LID - S2161-8313(26)00156-0 [pii] LID - 10.1016/j.advnut.2026.100742 [doi] AB - Multisectoral nutrition (MSN) approaches coordinate interventions across sectors, such as health, agriculture, education, and social protection, to improve nutrition outcomes and have gained prominence in low- and middle-income countries (LMICs). Measuring co-coverage-the clustering of multiple interventions at the individual and household level-remains uncommon yet offers a viable method for tracking MSN intervention coverage. This scoping review examined existing analytic approaches and applications for assessing the co-coverage of health and nutrition interventions. We searched Web of Science Core Collection, PubMed, and EBSCOhost for studies that used, described, or developed co-coverage methods to measure nutrition- and health-related intervention coverage. Titles and abstracts were screened by 2 independent reviewers (SG and NP) using Covidence, followed by full-text screening based on predefined criteria. Screening 4478 abstracts yielded 73 eligible studies applying 8 distinct methods to quantify co-coverage across health and nutrition interventions. Most studies were observational (90%) and conducted in LMICs, particularly sub-Saharan Africa and South Asia, with publications increasing over the past decade. Data were primarily drawn from surveys (93%), particularly Demographic and Health Surveys (41 studies). Commonly included individual level interventions in co-coverage indices were antenatal care (ANC, 66 studies) or ANC components, child immunizations (48 studies), and skilled birth attendance (42 studies). Evidence on measuring a range of multisectoral interventions at the household level was limited. Intervention selection was often guided by established frameworks or guidelines. Coverage indices were calculated using simple counts, weighted averages, and scoring systems. Although 18 studies validated their indices through methods such as Cohen's kappa and sensitivity analyses, most relied on previously used approaches without specific validation. These findings underscore the considerable variability in co-coverage methodologies and the need for greater harmonization and validation to enable consistent monitoring of multisectoral nutrition progress. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Manohar, Swetha AU - Manohar S AD - Nutrition, Diet and Health Unit, International Food Policy Research Institute, Washington, DC, United States. Electronic address: smanoha2@jhu.edu. FAU - Grounds, Samantha AU - Grounds S AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. FAU - Kim, Sunny S AU - Kim SS AD - Nutrition, Diet and Health Unit, International Food Policy Research Institute, Washington, DC, United States. FAU - Pandya, Niharika AU - Pandya N AD - Nutrition, Diet and Health Unit, International Food Policy Research Institute, Washington, DC, United States. FAU - Morrison, Taylor AU - Morrison T AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. FAU - Nguyen, Phuong Hong AU - Nguyen PH AD - Nutrition, Diet and Health Unit, International Food Policy Research Institute, Washington, DC, United States. LA - eng PT - Journal Article PT - Review DEP - 20260930 PL - United States TA - Adv Nutr JT - Advances in nutrition (Bethesda, Md.) JID - 101540874 SB - IM OTO - NOTNLM OT - co-coverage OT - coverage OT - coverage measurement OT - maternal and child nutrition OT - multisectoral nutrition OT - nutrition and health interventions COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/09/30 23:30 MHDA- 2026/09/30 23:30 CRDT- 2026/09/30 19:29 PHST- 2025/12/13 00:00 [received] PHST- 2026/09/13 00:00 [revised] PHST- 2026/09/26 00:00 [accepted] PHST- 2026/09/30 23:30 [pubmed] PHST- 2026/09/30 23:30 [medline] PHST- 2026/09/30 19:29 [entrez] AID - S2161-8313(26)00156-0 [pii] AID - 10.1016/j.advnut.2026.100742 [doi] PST - aheadofprint SO - Adv Nutr. 2026 Sep 30;17(11):100742. doi: 10.1016/j.advnut.2026.100742. PMID- 42815152 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261002 IS - 1460-2237 (Electronic) IS - 0268-1080 (Print) IS - 0268-1080 (Linking) VI - 41 IP - Supplement_2 DP - 2026 Sep 30 TI - Developing global measurement guidance to strengthen adolescent well-being data generation and use at country level. PG - ii57-ii68 LID - 10.1093/heapol/czaf106 [doi] AB - Adolescence is a critical life stage marked by rapid physical, cognitive, and social development with implications for well-being in adulthood and of subsequent generations. Although global attention to adolescent well-being has grown over the past decade, efforts to measure it remain fragmented, sector specific, and include a greater number of indicators of risks and negative outcomes compared to positive well-being. To address these challenges, the World Health Organization, in collaboration with the Partnership for Maternal, Newborn and Child Health and other United Nations (UN) partners, developed new measurement guidance to support countries in assessing adolescent well-being in a holistic, multisectoral way across the five domains of the UN's consensus Adolescent Well-being Framework (AWF) focused on health and nutrition, connectedness, safety, learning, and agency and resilience. This article describes the process and results of the guidance development. The process incorporated adolescent and youth perspectives, was supported by a multidisciplinary Expert Consultative Group and included several steps, starting with operationalizing the AWF for measurement. Draft guidance was then developed, and the feasibility of its implementation was assessed in Colombia, India, and South Africa. Feedback from country stakeholders led to substantial revisions-clarifying linkages to the broader measurement landscape, strengthening implementation information, and improving usability-before finalization. The guidance supports countries to identify and assemble existing data across all domains of the AWF, identify data gaps, assess current government-led efforts to improve adolescent well-being, and translate findings into action. Rather than prescribing new indicators or data collection efforts, it provides a structured approach and an Excel-based data tool to improve the use of existing data. By promoting a practical, country-led approach and building on existing systems, the guidance aims to support governments in strengthening insight, accountability, and action for adolescent well-being. CI - (c) World Health Organization, 2026. FAU - Keogh, Sarah C AU - Keogh SC AUID- ORCID: 0000-0002-2249-9565 AD - Maternal, Newborn, Child and Adolescent Health and Ageing Department, World Health Organization, 20 Avenue Appia, Geneva 1211, Switzerland. FAU - Newby, Holly AU - Newby H AUID- ORCID: 0000-0001-9195-5846 AD - Maternal, Newborn, Child and Adolescent Health and Ageing Department, World Health Organization, 20 Avenue Appia, Geneva 1211, Switzerland. FAU - Divala, Titus AU - Divala T AD - Maternal, Newborn, Child and Adolescent Health and Ageing Department, World Health Organization, 20 Avenue Appia, Geneva 1211, Switzerland. FAU - Abduvahobov, Parviz AU - Abduvahobov P AD - Division for Peace and Sustainable Development, Health and Education Section, Education Sector, United Nations Educational, Scientific and Cultural Organization, 7 Pl. de Fontenoy-UNESCO, Paris 75007, France. FAU - Baird, Sarah AU - Baird S AD - Department of Global Health, Milken Institute School of Public Health, George Washington University, 950 New Hampshire Ave NW, 4th floor, Washington, DC 20037, United States. FAU - Chatterjee, Tapas AU - Chatterjee T AD - WHO Country Office for India, Office of the WHO Representative to India, 537, A Wing, Nirman Bhawan, Maulana Azad Road, New Delhi 110 011, India. FAU - Deardorff, Julianna AU - Deardorff J AD - School of Public Health, University of California, Berkeley, 2121 Berkeley Way, Berkeley, CA 94704, United States. FAU - Degraff, Evelyne AU - Degraff E AD - Organizacion Panamericana de la Salud, Carrera 9 No. 76-49 Piso 5 oficina 501 - 502, Edificio El Nogal, Bogota D.C., Colombia. FAU - de Jong, Renee AU - de Jong R AD - Partnership for Maternal Newborn and Child Health, 20 Avenue Appia, Geneva 1211, Switzerland. FAU - Dlamini-Nqeketo, Sithembile AU - Dlamini-Nqeketo S AD - WHO Country Office for South Africa, 351 Francis Baard St, Pretoria Central, Pretoria 0002, South Africa. FAU - Engel, Danielle AU - Engel D AD - United Nations Population Fund, 730 Third Avenue, New York, NY 10017, United States. FAU - Gebremichael, Tamrat AU - Gebremichael T AD - Plan Canada, 245 Eglinton Ave E #300, Toronto, ON M4P 0B3, Canada. FAU - Karna, Priya AU - Karna P AD - WHO Country Office for India, Office of the WHO Representative to India, 537, A Wing, Nirman Bhawan, Maulana Azad Road, New Delhi 110 011, India. FAU - Klein, Jonathan D AU - Klein JD AD - Department of Pediatrics, Adolescent Medicine, Stanford University, 750 Welch Rd, Suite 210, Palo Alto, CA 94304, United States. FAU - Mackworth-Young, Constance AU - Mackworth-Young C AD - London School of Hygiene and Tropical Medicine and Biomedical Research and Training Institute, 10 Seagrave Road, Avondale, Harare, Zimbabwe. FAU - Magoro, Terrance AU - Magoro T AD - WHO Country Office for South Africa, 351 Francis Baard St, Pretoria Central, Pretoria 0002, South Africa. FAU - Mamun, Abdullah Al AU - Mamun AA AD - Poche Centre for Indigenous Health, Faculty of Health, Medicine and Behavioural Sciences, The University of Queensland, 74 High St, Brisbane, QLD 4066, Australia. FAU - Marquez, Jose AU - Marquez J AD - Wellbeing Research Centre, Harris Manchester College, University of Oxford, Mansfield Rd, Oxford OX1 3TD, United Kingdom. FAU - Nenzhelele, Hlamalani Queen AU - Nenzhelele HQ AD - National Department of Health, Dr. AB Xuma Building, 1112 Voortrekker Road, Pretoria Townlands 351-JR, Pretoria 0187, South Africa. FAU - Ramirez Ruiz, Mily AU - Ramirez Ruiz M AD - Ministerio de Salud y Proteccion Social, Carrera 13 32-76, Bogota D.C. 110311, Colombia. FAU - Requejo, Jennifer AU - Requejo J AD - Global Financing Facility for Women, Children and Adolescents, World Bank Group, 1818 H Street NW, Washington, DC 20433, United States. AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, United States. FAU - Rizvi, Zoya Ali AU - Rizvi ZA AD - Adolescent Health and Nutrition Division, Ministry of Health & Family Welfare, Government of India, Nirman Bhawan, New Delhi 110011, India. FAU - Mohan, Anshu AU - Mohan A AD - Partnership for Maternal Newborn and Child Health, 20 Avenue Appia, Geneva 1211, Switzerland. FAU - Guthold, Regina AU - Guthold R AUID- ORCID: 0000-0003-3073-6468 AD - Maternal, Newborn, Child and Adolescent Health and Ageing Department, World Health Organization, 20 Avenue Appia, Geneva 1211, Switzerland. LA - eng PT - Journal Article PL - England TA - Health Policy Plan JT - Health policy and planning JID - 8610614 SB - IM MH - Humans MH - Adolescent MH - *Adolescent Health MH - Psychological Well-Being MH - Global Health MH - World Health Organization MH - United Nations PMC - PMC13626659 OTO - NOTNLM OT - adolescent data OT - adolescent health OT - global guidance OT - measurement OT - well-being COIS- Conflicts of interest: None declared. EDAT- 2026/09/30 23:30 MHDA- 2026/09/30 23:31 PMCR- 2026/09/30 CRDT- 2026/09/30 18:05 PHST- 2025/12/02 00:00 [accepted] PHST- 2026/09/30 23:31 [medline] PHST- 2026/09/30 23:30 [pubmed] PHST- 2026/09/30 18:05 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - 8845399 [pii] AID - czaf106 [pii] AID - 10.1093/heapol/czaf106 [doi] PST - ppublish SO - Health Policy Plan. 2026 Sep 30;41(Supplement_2):ii57-ii68. doi: 10.1093/heapol/czaf106. PMID- 42814958 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261002 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Sep 30 TI - Fascial Manipulation Compared to Stretching for Rehabilitation of Children With Cerebral Palsy: Protocol for a Pilot Randomized Controlled Trial. PG - e92401 LID - 10.2196/92401 [doi] LID - e92401 AB - BACKGROUND: Maintaining and improving motor function is essential in the rehabilitation of children with cerebral palsy (CP). Stretching is traditionally used to prevent muscle tightness and contractures to improve movement patterns in children with CP. Fascial manipulation (FM) is an increasingly used manual therapy method for movement difficulties associated with CP. However, evidence for FM remains limited, and its benefits over conventional stretching are unclear. A pilot randomized controlled trial (RCT) is warranted to assess the feasibility and acceptability of a definitive trial comparing FM with stretching. This study protocol describes a pilot randomized controlled feasibility trial comparing FM and stretching in children with CP to inform the design and conduct of a future definitive RCT. OBJECTIVE: The primary objective is to assess the feasibility and acceptability of the trial procedures and interventions. This includes evaluating recruitment and retention rates, intervention adherence, completion rates for outcome assessments, and the perceived impact of the interventions on children's daily functioning and participation. The secondary objective is to explore the preliminary acute and longitudinal effects of FM, compared with traditional stretching, on walking performance, gait biomechanics, joint mobility, and the variability in these outcome measures. METHODS: This pilot RCT will include 20 children aged 7 to 14 years with spastic CP, randomized to an FM intervention group (n=10) and a stretching group (n=10). Both groups will receive 1 treatment session per week for 8 weeks. Feasibility and acceptability will be assessed using quantitative measures of recruitment and retention, intervention adherence, and completion of outcome assessments, complemented by semistructured interviews with caregivers and the children's regular physiotherapists to explore perceived changes in the children's daily functioning and participation, and their experiences of the interventions. Secondary outcomes include the 6-minute walk test (6MWT), walking metabolic cost, gait biomechanics, ankle spasticity, muscle activity, joint stiffness, and functional mobility in daily life. Acute outcomes will be assessed before and after the first intervention session, while longitudinal outcomes will be assessed at baseline and following the 8-week intervention period. RESULTS: Recruitment of participants began in October 2024, with 3 additional participants required to reach the target sample size. Results are expected to be published in 2027. CONCLUSIONS: This pilot RCT will provide essential feasibility data and preliminary estimates of potential treatment effects to inform the design of a future adequately powered RCT. To our knowledge, evidence regarding the effects of FM on gait, mobility, and function in children with CP remains limited. This study aims to contribute to the development of evidence-based rehabilitation strategies for children with CP. CI - (c) Karin von Smitten-Stubb, Joachim Ring, Piia Haakana, Heikki Hurri, Mira Huusko, Ira Jeglinsky-Kankainen, Jyrki Kettunen, Juha-Pekka Kulmala, Taru Laakso, Tiina Lahtinen-Suopanki, Essi Marttinen Rossi, Helena Maenpaa, Tuula Niemela, Mika Peltoniemi, Leena Ristolainen, Petri Salonen, Eva Teijonsalo, Nita Tolvanen. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - von Smitten-Stubb, Karin AU - von Smitten-Stubb K AUID- ORCID: 0009-0000-7359-4709 AD - University of Helsinki, Helsinki, Uusimaa, Finland. FAU - Ring, Joachim AU - Ring J AUID- ORCID: 0000-0002-1557-5152 AD - Arcada University of Applied Sciences, Helsinki, Uusimaa, Finland. FAU - Haakana, Piia AU - Haakana P AUID- ORCID: 0000-0003-0005-3834 AD - Helsinki Children's Hospital, Stenbackinkatu 9, Helsinki, Uusimaa, Finland, 358 40 4863595. FAU - Hurri, Heikki AU - Hurri H AUID- ORCID: 0000-0002-1672-6960 AD - Research Institute Orton, Helsinki, Finland. FAU - Huusko, Mira AU - Huusko M AUID- ORCID: 0000-0003-2726-7250 AD - Finnish Education Evaluation Centre, Helsinki, Finland. FAU - Jeglinsky-Kankainen, Ira AU - Jeglinsky-Kankainen I AUID- ORCID: 0000-0002-2162-4168 AD - Arcada University of Applied Sciences, Helsinki, Uusimaa, Finland. FAU - Kettunen, Jyrki AU - Kettunen J AUID- ORCID: 0000-0002-4155-7150 AD - Research Institute Orton, Helsinki, Finland. FAU - Kulmala, Juha-Pekka AU - Kulmala JP AUID- ORCID: 0000-0003-1881-4689 AD - Helsinki Children's Hospital, Stenbackinkatu 9, Helsinki, Uusimaa, Finland, 358 40 4863595. FAU - Laakso, Taru AU - Laakso T AUID- ORCID: 0009-0001-4824-873X AD - Terapia-asema Voima Oy, Espoo, Finland. FAU - Lahtinen-Suopanki, Tiina AU - Lahtinen-Suopanki T AUID- ORCID: 0009-0003-5871-1622 AD - Independent physiotherapist, Helsinki, Finland. FAU - Rossi, Essi Marttinen AU - Rossi EM AUID- ORCID: 0000-0002-7811-875X AD - Helsinki Children's Hospital, Stenbackinkatu 9, Helsinki, Uusimaa, Finland, 358 40 4863595. FAU - Maenpaa, Helena AU - Maenpaa H AUID- ORCID: 0009-0005-5505-3489 AD - Motion Analysis Laboratory, Helsinki University Hospital, Helsinki, Finland. AD - University of Helsinki, Children and Adolescent, Helsinki, Finland. FAU - Niemela, Tuula AU - Niemela T AUID- ORCID: 0009-0007-5873-5295 AD - Helsinki Children's Hospital, Stenbackinkatu 9, Helsinki, Uusimaa, Finland, 358 40 4863595. FAU - Peltoniemi, Mika AU - Peltoniemi M AUID- ORCID: 0009-0001-6582-1817 AD - Helsinki Children's Hospital, Stenbackinkatu 9, Helsinki, Uusimaa, Finland, 358 40 4863595. FAU - Ristolainen, Leena AU - Ristolainen L AUID- ORCID: 0000-0002-3041-260X AD - Research Institute Orton, Helsinki, Finland. FAU - Salonen, Petri AU - Salonen P AUID- ORCID: 0009-0001-0970-7876 AD - Research Institute Orton, Helsinki, Finland. FAU - Teijonsalo, Eva AU - Teijonsalo E AUID- ORCID: 0009-0001-2032-1325 AD - Terapia-asema Voima Oy, Espoo, Finland. FAU - Tolvanen, Nita AU - Tolvanen N AUID- ORCID: 0009-0004-5405-2348 AD - Independent physiotherapist, Helsinki, Finland. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260930 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - *Cerebral Palsy/rehabilitation/physiopathology MH - Child MH - Pilot Projects MH - Adolescent MH - Female MH - *Muscle Stretching Exercises MH - Male MH - Randomized Controlled Trials as Topic MH - Feasibility Studies MH - *Musculoskeletal Manipulations/methods PMC - PMC13626396 OTO - NOTNLM OT - cerebral palsy rehabilitation OT - fascial manipulation OT - range of motion OT - spasticity OT - stretching OT - walking COIS- Conflicts of Interest: The authors declare the following potential conflict of interest: NT is a self-employed physiotherapist who provides fascial manipulation treatment in her professional practice, including as an intervention provider in this study. To minimize potential bias, she was not involved in the analysis or interpretation of the study outcomes. The other authors declare no conflicts of interest. EDAT- 2026/09/30 17:32 MHDA- 2026/09/30 17:33 PMCR- 2026/09/30 CRDT- 2026/09/30 16:24 PHST- 2026/01/29 00:00 [received] PHST- 2026/07/30 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/09/30 17:33 [medline] PHST- 2026/09/30 17:32 [pubmed] PHST- 2026/09/30 16:24 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - v15i1e92401 [pii] AID - 92401 [pii] AID - 10.2196/92401 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Sep 30;15:e92401. doi: 10.2196/92401. PMID- 42814674 OWN - NLM STAT- In-Process LR - 20260930 IS - 1423-0143 (Electronic) IS - 1420-4096 (Linking) VI - 51 IP - 1 DP - 2026 TI - Erratum. PG - 915-922 LID - 10.1159/kbr/adjag008 [doi] AB - In the article "Lipids and Lipid Metabolites in the Diagnosis, Risk Prediction, and Treatment of Chronic Kidney Disease and Acute Kidney Injury: A Narrative Review" [Kidney Blood Press Res. 2026;51:567-588. https://doi.org/10.1159/000552568] by Erfurt et al. Table 1 was incorrectly transferred during the production process. A corrected version of Table 1 is available below.Table 1.Summaries of all studies discussed, including design and outcomesReferenceDesignMethodologyMain findingsConclusionDiagnostic and prognostic role of fatty acids and their metabolites in CKDShearer et al. [36] (2012)Comparison of plasma fatty acid (FA) profiles in patients with stage 3-4 CKD (n = 10), stage 5 CKD near dialysis initiation (n = 20; one excluded for poor FA recovery), and 10 non-CKD controls from Karolinska prospective cohorts (mean follow-up for stage 5 = 2.7+/-1.7 years)FAs measured by gas chromatography; eGFR (MDRD) and FA relationships assessed using Deming orthogonal regression and Cox models (age-adjusted)Stage 5 CKD patients had lower relative abundances of polyunsaturated Fas - especially arachidonate synthesis intermediates - and lower stearic acid; EPA was lower in stage 5 vs. stage 3-4 and controls. Monounsaturated FAs showed opposing trends with declining eGFR (palmitate decreased, oleic acid increased). Nervonic acid abundance was a strong age-adjusted predictor of mortality in dialysis patientsMetabolic intermediates of arachidonic acid synthesis are reduced in CKDNervonic acid significantly predicts all-cause mortalityAfshinnia et al. [39] (2016)Nested case-control study used fasting serum from a subcohort of the CRIC cohort to identify lipidomic predictors of progression to end-stage kidney disease (ESKD)LC-MS shotgun lipidomics510 lipids detected (382 after filtering); 49 showed nominal differences between progressors and nonprogressors. Statistical selection combined t tests with FDR correction, PLS-DA, and Random Forest, and candidates were tested in logistic regression models adjusted for eGFR, UPCR, demographics, diabetes, hypertension, and heart failure. Two diacylglycerols (DAG 36:0 and DAG 32:0) were lower in progressors and each 1-SD higher level was associated with substantially reduced progression risk; monoacylglycerol MAG 16:0 was higher in progressors and associated with increased risk. Class-level findings showed enrichment and differential regulation of cholesterol esters, DAGs, and phosphatidylethanolamines, with chain length and unsaturation patterns differing between groupsMultimarker lipid panels significantly improve discrimination vs. a base model (eGFR + UPCR)Gollasch et al. [37] (2020)Comparison of fatty acid profiles in 15 healthy volunteers and 15 end-stage kidney disease (ESKD) patients on maintenance hemodialysis (HD)Venous blood collected from controls and pre-/post-HD from patients; RBC and plasma fatty acids measured by HPLC-MSESRD patients showed altered RBC and plasma fatty acid patterns: reduced EPA (C20:5 n-3) and certain n-6 species and increased very-long-chain monounsaturated fatty acids (e.g., C24:1 n-9); most free fatty acids were higher in plasma and RBCs of patients. A single HD session produced only minor changes in several total plasma saturated and n-6 fatty acids and did not meaningfully change RBC fatty acid composition or the RBC omega-3 indexTotal fatty acid levels differed significantly in RBCs from healthy controls and CKD patients, hemodialysis has no effect on plasma or RBC fatty acid levelsSikorska-Wisniewska et al. [38] (2020)Cohort (n = 134) of 3 groups: patients after renal transplantation (RTx group, n = 24), patients with CKD in stages 2-5, not on dialysis (CKD-ND group, n = 67), and controls without CKD (n = 43)Fatty acids (FA) assessed by gas chromatography-mass spectrometry; same FA analysed in samples of adipose tissue taken during the kidney transplantation procedure and compared with FA of controlsSerum omega-3 and omega-6 PUFA levels were highest in controls and lowest in RTx patients. No associations were found between GFR and FA levels. Fish intake correlated with EPA/DHA levels in some groups, but ALA intake did not correlate with serum ALA; EPA, DHA, LA, and AA generally correlated inversely with triglycerides (some correlations reached significance), while no meaningful links were found with CRP, albumin, BMI, or adipose tissue PUFA compositionRTx patients present significantly lower serum content of all the examined PUFAs, in comparison to the CKD-ND group and controlsLanzon et al. [47] (2021)Comparison of 11 severely obese patients with chronic kidney disease (OD) and 14 obese controls without CKD (O)Serum lipidomics (LC-MS) and polar metabolomics (GC-HRAM-MS)Lipidomics: 71 serum lipids differed (most increased in OD), notably rises in TGs (many unsaturated, short-/medium-chain), diglycerides (DGs), phosphatidylcholines (PCs), lysophosphatidylcholines (LysoPCs) and plasmalogens, while sphingomyelins (SMs) and phosphatidylinositols (PIs) decreased. Short-chain TGs correlated negatively with eGFR in OD; many lipids correlated with glucose in O but not in OD. Metabolomics: several essential and conditionally essential amino acids (e.g., isoleucine, lysine, proline) were higher in OD. After bariatric surgery OD patients showed lipidomic shifts toward profiles closer to O; DGs and medium-chain TGs correlated with uric acid post-surgery. Serum levels of several essential amino acids (isoleucine, lysine, threonine, valine) and some conditional amino acids fell after surgery; urine valine and glutamine decreased while hippuric acid increasedResults justify the use of lipidomics to validate possible early markers of risk of CKD in patients with severe obesityMika et al. [40] (2021)Study of 198 kidney transplant (Tx) patients (age 18-70) and 48 matched controlsAnalysis of fasting plasma fatty acid (FA) profiles by GC-MS after Folch extractionTx patients - treated with standard triple immunosuppression and excluding FA supplement users - showed distinct FA alterations vs. controls: lower long- and very-long-chain saturated and polyunsaturated FAs (many n-3/n-6 PUFA and branched-chain FAs), but higher palmitic (16:0) and certain monounsaturated FAs (16:1, 18:1). Disturbances were greatest within the first month post-transplant (Tx1M) and partially normalized by >12 months, though differences from controls persisted. PCA and hierarchical clustering clearly separated Tx and control groups. Comorbidities and clinical factors affected profilesFA profiles are significantly different between patients and controls, tendency for normalization in long-term kidney recipients, n-3 PUFA strong inverse associated with inflammationPinto et al. [41] (2021)Investigation of relationships between dialysis, sleep and 24 h heart rate variability (HRV) and LC n-3 PUFA status in hemodialysis patients (CKD stage 5) (n = 45)Pre-dialysis blood samples, measurement of erythrocyte and plasma fatty acid compositionCompared with controls, patients had higher heart rates, lower HRV, more inflammation, and lower LC n-3 PUFA levels; erythrocyte omega-3 index was low overall. While no consistent associations were found for erythrocyte O3I, EPA, or DHA with HRV, plasma DHA correlated positively with HRV during dialysis, plasma EPA with 24-h HRV, and EPA:DHA ratio, DPA(n-3), and EPA showed mixed inverse or negative associations with short-term HRV, indicating a complex relationshipImpaired EPA metabolism might contribute to sudden cardiac death (SCD) risk increase in dialysis patientsSledzinski et al. [42] (2022)Study of 35 CKD patients (19 men, 16 women; age 22-70) comparison of serum fatty acid (FA) profiles before and 3 months after deceased-donor kidney transplantationCollection of fasting serum, lipids extracted and converted to FAMEs, subsequently analyzed by GC-EI-MSTotal even-chain saturated FAs, odd- and branched-chain FAs, and total SFAs did not change, but specific FAs shifted: decreases in some 12-, 18-, and 26-carbon FAs, a rise in palmitic acid (16:0), and a significant reduction in ultra-long-chain FAs (>/=26C), especially 26:0. Total MUFAs were unchanged though 20:1 increased and the 18:1/18:0 desaturation index rose. Among PUFAs, total n-6 was stable despite decreases in DGLA (20:3n-6), ARA, and AdA (22:4n-6) while 18:2n-6 increased; total n-3 PUFAs declinedSignificant reduction in n-3 PUFAs in renal transplant recipients 3 months after transplantation, which may contribute to increased cardiovascular riskSledzinski et al. [45] (2024)Prospective study of 25 CKD patients (23 deceased-donor, 2 living-donor)Quantification of serum fatty acid (FA) profiles before kidney transplantation (KTx), 3 months after, and 6-12 months after. Samples analyzed by GC-MSTotal saturated FAs were largely unchanged except for an increase in odd-chain SFAs; very-long-chain FAs (>20C) rose by 6-12 months, whereas ultra-long-chain FAs (>/=26C) fell progressively. Total MUFAs were stable overall, but C20:1, C22:1, C24:1 increased and C18:1 trended down. Total n-3 PUFAs (including DHA) and some n-6 PUFAs (ARA, DGLA) decreased at 3 months then increased by 6-12 months; linoleic acid rose at 3 monthsFA dynamics following KTx are complex and may indicate a need for supplementationMantovani et al. [46] (2023)Follow-up of 85 post-menopausal women with non-insulin-treated T2DM and preserved kidney function at baselineSerum NEFA concentrations measured using enzymatic colorimetric method, eGFR was estimatedHigher baseline NEFA levels strongly predicted kidney function decline. Patients in the highest NEFA tertile had significantly greater risk by Kaplan-Meier analysisHigher circulating levels of NEFA strongly associated with faster kidney function declineOng et al. [43] (2023)Pooled analysis by the Fatty Acids and Outcomes Research Consortium, combination of de novo data from 19 prospective cohorts (25,570 participants without baseline CKD; median follow-up 11.3 years) to examine circulating/adipose n-3 PUFA biomarkers and risk of incident chronic kidney disease (CKD)Biomarkers (ALA, EPA, DPA, DHA) were measured by gas chromatography in various lipid compartments, and incident CKD was defined as follow-up eGFR <60 mL/min/1.73 m2 among those with baseline eGFR >/=60See "Conclusion"Meta-analyses (adjusted Cox/Poisson and linear models) showed higher seafood-derived n-3 PUFAs (EPA/DPA/DHA) were associated with lower risk of incident CKD (8% lower per interquintile range; highest vs. lowest quintile RR 0.87) and with slower annual eGFR decline; results were consistent across compartments and sensitivity analyses. ALA showed no association with incident CKD or eGFR decline. Associations were not modified by age, race, hypertension, diabetes, coronary disease, or baseline eGFRKoh et al., 2024 [44]Prospective observational cohort study, 73.419 participants without CKD and 6. 735 with CKDAnalysis of systemic PUFA levelsHigher PUFA levels - especially omega-3s like DHA - were linked to lower risk of developing CKD and reduced all-cause mortality; higher PUFA levels also correlated with younger age, female sex, nonwhite race, nonsmoking, and healthier clinical profilesAmong participants without CKD, higher plasma levels of total PUFAs are associated with a lower risk of developing CKDFatty acids, their metabolites and modulators of fatty acid metabolism in CKD managementBarden et al. [55] (2015)Double-blinded, placebo-controlled intervention, CKD patients randomized to n-3 fatty acids, CoQ, both or control, daily for 8 weeksExamination of n-3 fatty acid effects on plasma and urinary 20-HETE, plasma and urinary F2-isoprostanes, changes in blood pressureTreatment raised platelet n-3 and plasma CoQ (confirming compliance) and significantly lowered plasma 20-HETE and F2-isoprostanes (urinary levels unchanged) and reduced systolic and diastolic BP during both awake and asleep periods. Post-intervention 20-HETE was positively associated with 24-h SBP and DBP (driven by daytime BP)Identification of a plausible mechanism underlying the reduction in blood pressure observed in patients with chronic kidney disease after omega-3 fatty acid supplementationHu et al. [56] (2017)Review and meta-analysis: 9 RCT with CKD patients includedEvaluation of the benefits and risks of omega-3 fatty acid supplementationSee "Conclusion"Omega-3 supplementation significantly reduces proteinuria and lowers risk of ESKD but does not significantly affect creatinine clearance rate or eGFR. Subgroup analysis shows location, age, and study quality influences the proteinuria benefitDe Boer et al. [57] (2019)RCT: 1,312 adults with type 2 diabetesRandomization to receive vitamin D3 and omega-3 fatty acids and placebo for 5 years, primary outcome: GFR changeNo significant differences in eGFR, urine ACR, or a composite of kidney failure/death between supplement and placebo groups. Adverse events similar across groupsResults do not support use of vitamin D or omega-3 fatty acid supplementationValle Flores et al. [58] (2020)Prospective, randomized, double-blind study in CKD patients undergoing hemodialysisTwo groups: group A (46 patients) received omega-3 fatty acids during 12-week, control group (group B, 47 patients) received paraffin oil, general characteristics, analysis of nutritional indicators, renal disease markers and CRP, IL-6, IL-10, and TNF-alpha evaluatedOmega-3 supplementation produced significant reductions in inflammatory markers and significantly raised the IL-10/IL-6 ratio, while IL-10 increased nonsignificantly; no meaningful changes in the control groupOral omega-3 fatty acid supplementation significantly reduces inflammatory marker concentrations in patients with chronic kidney disease undergoing hemodialysisBunout et al. [59] (2021)RCT: 100 CKD patients supplemented for 3 months with docosahexaenoic and eicosapentaenoic acids or a corn oil supplementEvaluation at baseline, 6 weeks, 12 weeks; variables: blood and morning spot urine samples, blood pressure, carotid intima media thickness, and pulse wave velocity, main outcome: reduction of >/=20% in urine albuminThe n-3 PUFA group showed significant rises in EPA/DHA and omega-3 index and a drop in triglycerides, while both groups had reductions in urine albumin excretion (no significant between-group difference). Pulse wave velocity remained stable with n-3 PUFA but increased in controls; HbA1c rose in both groups and inflammatory markers were unchanged. Secondary analysis revealed systolic blood pressure fall in n-3 PUFA usersOmega-3 fatty acid supplement does not modify urine albumin excretion in patients with CKD but improves pulse wave velocity and serum triglyceride levelsLin et al. [60] (2022)Investigation of oral supplementation with omega-3 PUFA on circulating IL-6, cardiometabolic parameters, skin moisturization, and symptoms of pruritus in hemodialysis patientsTwenty-seven subjects consumed fish oil daily for 3 months and were measured at baseline, first, second, and third month post-supplementationFish oil did not change BMI, serum calcium, phosphorus, or iPTH but significantly reduced pruritus and improved skin hydration. Inflammatory markers (CRP, IL-6), plasma creatinine, and several lipid measures (total cholesterol down, HDL up, TG improved; LDL fell then rose slightly by month three) also improvedOmega-3 PUFA beneficial in hemodialysisAo et al. [61] (2024)24,497 patients with diabetes includedCox proportional hazards regression models used to estimate hazard ratios for CKD risk and impact of fish oilAdjusted analyses found lower CKD risk in diabetic patients who used fish oil and an approximate 2.79-year delay in CKD onset, with stronger effects in men, older adults, non-smokers, and those with healthier diets. Fish oil use also associated with lower HbA1c and CRP and higher HDLFish oil might reduce CKD risk in diabeticsFei et al. [62] (2024)Review and meta-analysis: 9 studies, total of 347 proteinuric participants included in the analysisAnalysis of the impact of omega-3 fatty acid supplementation on proteinuriaSee "Conclusion"Pooled results using fixed- and random-effects models showed non-significant standardized mean differences, with substantial heterogeneity. Study quality was moderate (JADAD 2-4); funnel plot showed no clear publication bias but power was limited by few studies. Overall, omega-3s did not demonstrate a significant anti-proteinuric benefit, though heterogeneity limits confidenceLok et al. [63] (2026)Double-blinded randomized trial of 1,228 adults on maintenance hemodialysisDaily fish-oil supplementation (4 g n-3 fatty acids: 1.6 g EPA + 0.8 g DHA) in comparison with corn-oil placebo over 3.5 yearsFish-oil significantly reduced the rate of serious cardiovascular events (primary end point) vs. placebo and lowered risks of cardiac death, myocardial infarction, stroke, and amputations, with similar adherence and adverse events between groupsFish-oil reduces cardiovascular and mortality risk in hemodialysis patientsDiagnostic and prognostic role of fatty acids and their metabolites in AKIWang et al. [50] (2020)Prospective pilot study: pediatric intensive care, 101 sepsis patients, 30 healthy controlsSerum ApoA5 levels were determined by ELISAApoA5 was lower in septic children than healthy controls and significantly lower in nonsurvivors vs. survivors, correlating with MODS and AKI; low ApoA5 was an independent risk factor for PICU mortality. ROC analysis showed ApoA5 had diagnostic and prognostic value, and it correlated positively with serum calciumLower serum ApoA5 level predicts sepsis-associated complications, e.g., AKI, or MODS in childrenSun et al. [51] (2021)Pilot study: 17 patients with new diagnosed AKI and 17 healthy controlsSerum metabolomic profilingFrom thousands of ion features, 51 reliable metabolites were examined; 1-arachidonoyl-lysoPC was prominent on day 1, while creatine, citrulline, and others distinguished survivors from non-survivors at day 8, with higher levels in those who died. Multimetabolite ROC models predicted outcomes: a 4-metabolite (m4) day-1 model performed best for mortality, an 11-metabolite (m11) day-8 model showed high specificity, and a 3-metabolite (m3) model predicted KRT independence with a favorable AUCDistinct metabolite panels enable assessment of mortality risk in acute kidney injury (AKI)Zhang et al. [53] (2022)Retrospective, observational cohort study: 1,028 patients with primary nephrotic syndrome, AKI (n = 81), non-AKI (n = 947)Examination of serum free fatty acids by enzyme endpoint methodsPrematch, AKI patients were older, more often male, and had more infections, higher SBP, BMI, proteinuria, and serum free fatty acids (FFA), plus lower albumin and HDL. After propensity matching (77 pairs), multivariate analysis found infection, higher SBP, greater proteinuria, and higher FFA associated with AKI No FFA differences by stage or pathological type; FSGS had the highest AKI incidenceSerum FFA showed only weak diagnostic value for AKIin primary nephrotic syndromeZhou et al. [54] (2023)Prospective cohort study: 67 patients with sepsis associated AKI and 20 healthy controlsOxidative lipid analysis in plasma samples, liquid chromatography, tandem mass spectrometric detectionPlasma oxidative lipidomics reveals 21 significantly oxidized lipids. Machine learning (Random Forest, LASSO) highlighted five key biomarkers - particularly 9,10-DiHOME and 5,6-DiHETrE. Pathway analysis showed altered lipid metabolism, including downregulation of vascular smooth muscle contraction and involvement of serotonergic synapse pathwaysIdentification of 9,10-DiHOME and 5,6-DiHETrE as potential biomarkers for detecting sepsis associated AKI, 5-isoPGF2VI: a potential biomarker to distinguish AKI stage III from AKI stages I-II.Zhou et al. [48] (2025)Prospective cohort study in 17 patients with cardiac surgery-associated acute kidney injury (CSA-AKI) and 17 controlsLipidomic analysis through liquid chromatography-mass spectrometry (LC-MS)Broad lipidomic profiling found most differentially expressed lipids were upregulated in CSA-AKI, including acylcarnitines, cholesteryl esters, certain ceramides, lysophosphatidic acids, lysosphingomyelins, PG, and PIP species. Multivariate and network analyses implicated altered glycerophospholipid metabolism and flagged PE(14:0/22:2) and PE(39:1) as early-increased candidates, while PI(18:0/18:1) showed broad negative correlationsIdentification of PE(14:0/22:2) and PE(39:1) as early-increased candidates in CSA-AKIFatty acids, their metabolites and modulators of fatty acid metabolism in AKI managementHoogeveen et al. [64] (2014)2,344 patients with myocardial infarctionRandomization to 4 groups, substitution of eicosapentaenoic acid and docosahexaenoic acid, alpha-linolenic acid, eicosapentaenoic acid-docosahexaenoic acid and alpha-linolenic acid, or placebo for 40 months, eGFR measuredDaily EPA-DHA slows eGFR decline compared with placebo, with a larger benefit in those with baseline CKD. ALA showed no significant effect. EPA-DHA does not significantly reduce the incidence of CKD or rapid kidney-function decline, so effects were modest and variableLong-term supplementation with eicosapentaenoic acid-docosahexaenoic acid associated with small beneficial effects on kidney functionAlrowaie et al. [65] (2021)RCT: 130 patients undergoing coronary angiographyTwo groups: 67 received N-acetylcysteine (NAC), 63 received omega-3 fatty acid before interventionNAC group older with higher prevalence of hyperlipidemia, omega-3 group uses more ACEi/ARBs. Rates of contrast-induced nephropathy, kidney replacement therapy, in-hospital death, MI/stroke, and length of stay significantly not different between treatmentsOmega-3 fatty acids no beneficial effects on contrast-induced nephropathy. CI - (c) The Author(s) 2026. Published by S. Karger AG. LA - eng PT - Published Erratum DEP - 20260930 PL - Switzerland TA - Kidney Blood Press Res JT - Kidney & blood pressure research JID - 9610505 SB - IM EFR - Kidney Blood Press Res. 2026;51(1):567-588. doi: 10.1159/000552568. PMID: 42176287 EDAT- 2026/09/30 17:32 MHDA- 2026/09/30 17:32 CRDT- 2026/09/30 13:28 PHST- 2026/09/30 17:32 [medline] PHST- 2026/09/30 17:32 [pubmed] PHST- 2026/09/30 13:28 [entrez] AID - 000554466 [pii] AID - 10.1159/kbr/adjag008 [doi] PST - ppublish SO - Kidney Blood Press Res. 2026;51(1):915-922. doi: 10.1159/kbr/adjag008. Epub 2026 Sep 30. PMID- 42814221 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260930 LR - 20261003 IS - 2636-0780 (Electronic) IS - 2636-0772 (Print) IS - 2636-0772 (Linking) VI - 46 IP - 1 DP - 2026 Sep 30 TI - Recent trends in encapsulated bioactives for improving the delivery of infant milk fortifiers. LID - 10.1007/s44463-026-00114-4 [doi] LID - 107 AB - Low birth weight and preterm infants have increased nutritional requirements due to their limited nutrient reserves and physiological immaturity. However, both preterm mother's milk and donor human milk are often deficient in bioactive compounds which are necessary for immune protection, gastrointestinal maturation, and neurodevelopment. Fortifiers are frequently incorporated into human milk to improve its nutritional and functional qualities. This review discusses key bioactive compounds with potential for incorporation into infant milk fortifiers and looks at encapsulating technologies designed to protect bioactives throughout processing and gastrointestinal transit because of the physiological immaturity of preterm newborns. However, the lack of studies on GRAS-approved carriers for infants limits confidence in the applicability of current encapsulation approaches, although some safe encapsulation techniques and carriers have been investigated in infant formulas; data on their use in milk fortifiers remain limited. Encapsulation may be a promising strategy for increasing the efficacy of milk fortifiers. However, this review still identifies existing challenges, including limited clinical validation, safety concerns, and regulatory hurdles, and proposes practical solutions to support the safe and effective clinical application of encapsulated bioactives in neonatal nutrition. CI - (c) 2026. The Author(s). FAU - Latif, Samreen AU - Latif S AUID- ORCID: 0009-0005-8434-0372 AD - Department of Human Nutrition and Dietetics, School of Food and Agricultural Sciences, University of Management and Technology, 54000, Lahore, Pakistan. AD - Nur School of Nutritional Sciences, Nur International University, Lahore, Pakistan. FAU - Naseer, Muhammad Sadiq AU - Naseer MS AD - Nur School of Nutritional Sciences, Nur International University, Lahore, Pakistan. FAU - Khalid, Nauman AU - Khalid N AUID- ORCID: 0000-0002-8045-199X AD - Department of Human Nutrition and Dietetics, School of Food and Agricultural Sciences, University of Management and Technology, 54000, Lahore, Pakistan. nauman.khalid@umt.edu.pk. AD - College of Health Sciences, Abu Dhabi University, 59911, Abu Dhabi, United Arab Emirates. nauman.khalid@umt.edu.pk. FAU - Sarabandi, Khashayar AU - Sarabandi K AD - Research Institute of Food Science and Technology, Mashhad, Islamic Republic of Iran. LA - eng PT - Journal Article PT - Review DEP - 20260930 PL - Switzerland TA - Food Sci Anim Resour JT - Food science of animal resources JID - 101742126 PMC - PMC13627566 OTO - NOTNLM OT - GRAS carriers OT - Gastrointestinal stability OT - Lactoferrin OT - Neonatal nutrition OT - Preterm infants OT - Probiotics COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: As this article is a review paper, ethical approval was not required. EDAT- 2026/09/30 17:32 MHDA- 2026/09/30 17:33 PMCR- 2026/09/30 CRDT- 2026/09/30 11:18 PHST- 2026/04/14 00:00 [received] PHST- 2026/09/16 00:00 [accepted] PHST- 2026/07/14 00:00 [revised] PHST- 2026/09/30 17:33 [medline] PHST- 2026/09/30 17:32 [pubmed] PHST- 2026/09/30 11:18 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - 10.1007/s44463-026-00114-4 [pii] AID - 114 [pii] AID - 10.1007/s44463-026-00114-4 [doi] PST - epublish SO - Food Sci Anim Resour. 2026 Sep 30;46(1):107. doi: 10.1007/s44463-026-00114-4. PMID- 42813554 OWN - NLM STAT- Publisher LR - 20260930 IS - 1467-1107 (Electronic) IS - 1047-9511 (Linking) DP - 2026 Sep 30 TI - Beyond the obvious in childhood obesity: exploring cardiac electrophysiological balance index and subclinical risk. PG - 1-6 LID - 10.1017/S1047951126124275 [doi] AB - BACKGROUND: Childhood obesity is associated with adverse cardiovascular outcomes, including increased risk of arrhythmias and subclinical myocardial dysfunction. However, its impact on cardiac electrophysiological balance remains underexplored. The index of cardiac electrophysiological balance, calculated as QT/QRS ratio and corrected form of index of cardiac electrophysiological balance, emerged as novel electrocardiographic markers of ventricular arrhythmia risk. Although these parameters have been investigated in adult populations, data in obese children are lacking. This study aimed to evaluate the effects of obesity on index of cardiac electrophysiological balance and corrected form of index of cardiac electrophysiological balance in children and explore their associations with metabolic and anthropometric measures. METHODS: This retrospective cross-sectional study included 50 obese, 23 healthy children aged 10-18 years. Demographic, metabolic, electrocardiographic, and echocardiographic data were retrieved from hospital records. Index of cardiac electrophysiological balance, corrected form of index of cardiac electrophysiological balance, and repolarisation indices (QTc dispersion, Tp-e dispersion, and P-wave dispersion) were manually measured from 12-lead electrocardiograms. Associations with metabolic and anthropometric parameters were analysed using linear regression. RESULTS: Index of cardiac electrophysiological balance and corrected form of index of cardiac electrophysiological balance values were significantly lower in obese children than in controls (p < 0.001). QTc, Tp-e, and P-wave dispersions were also increased, indicating greater electrical heterogeneity. Index of cardiac electrophysiological balance showed negative correlations with LDL and total cholesterol levels. Tp-e duration and Tp-e/QTc ratio were inversely associated with hip circumference z-scores, possibly reflecting protective effects of gluteofemoral fat distribution. CONCLUSION: Childhood obesity may disrupt cardiac electrophysiological balance and repolarisation, even in the absence of overt cardiovascular disease. Index of cardiac electrophysiological balance and corrected form of index of cardiac electrophysiological balance could serve as early markers of arrhythmia risk. Prospective studies are needed to validate their prognostic significance. FAU - Caglayan Bozlak, Ozlem Hilal AU - Caglayan Bozlak OH AUID- ORCID: 0000-0002-1002-8432 AD - Pediatrics, Marmara Universitesi Egitim ve Arastirma Hastanesi, Turkiye. ROR: https://ror.org/02kswqa67 FAU - Arici, Sule AU - Arici S AD - Pediatric Cardiology, Kartal Kosuyolu High Specialization Training and Research Hospital, Istanbul, Turkiye. FAU - Karagozlu, Selen AU - Karagozlu S AUID- ORCID: 0000-0002-9542-1937 AD - Pediatric Cardiology, Marmara University Department of Pediatric Cardiology, Turkiye. FAU - Akalin, Figen AU - Akalin F AD - Pediatric Cardiology, Marmara University Department of Pediatric Cardiology, Turkiye. LA - eng PT - Journal Article DEP - 20260930 PL - England TA - Cardiol Young JT - Cardiology in the young JID - 9200019 SB - IM OTO - NOTNLM OT - Cardiovascular risk in children OT - cardiac electrophysiological balance index OT - childhood obesity OT - electrocardiography OT - paediatric cardiology OT - subclinical arrhythmia EDAT- 2026/09/30 11:35 MHDA- 2026/09/30 11:35 CRDT- 2026/09/30 07:15 PHST- 2026/09/30 11:35 [medline] PHST- 2026/09/30 11:35 [pubmed] PHST- 2026/09/30 07:15 [entrez] AID - S1047951126124275 [pii] AID - 10.1017/S1047951126124275 [doi] PST - aheadofprint SO - Cardiol Young. 2026 Sep 30:1-6. doi: 10.1017/S1047951126124275. PMID- 42813541 OWN - NLM STAT- Publisher LR - 20260930 IS - 1467-1107 (Electronic) IS - 1047-9511 (Linking) DP - 2026 Sep 30 TI - Maximum heart rate prediction in children: are maximal heart rate prediction equations suitable for use in paediatric clinical practice? PG - 1-6 LID - 10.1017/S1047951126124056 [doi] AB - AIMS: Assessment of maximal heart rate is used in clinical practice to determine the degree of beta-blockade during exercise and periods of adrenergic stress. When direct measurement is not possible, indirect methods utilising heart rate prediction equations are commonly used, but their validity in children has been challenged. METHODS: Retrospective data on 109 healthy children (male 63, 58%; mean age 11.00 +/- 3.09) undergoing routine exercise testing were analysed. Measured maximal heart rate was compared with estimates obtained from twenty-two prediction equations. RESULTS: All prediction equations overestimated maximal heart rate in males. In females, two equations underpredicted (Fairbarn and Heinzmann-Filho et al.), whilst the remaining equations overpredicted. The equations that predicted most accurately differed between males (Fairbarn) and females (Whyte (males). The prediction equation used commonly in clinical practice, Fox (220-age), overestimated significantly in males and females (p = < 0.001). A moderate positive correlation with age and maximal heart rate was seen in males only (r = 0.3195, p = 0.0107). CONCLUSIONS: This study shows that adult age regression equations do not accurately predict childhood maximal heart rate as determined by exercise testing. An inability to accurately predict maximal heart rate could have important implications for both childhood exercise prescription and the safe monitoring of pharmacological therapy that limits exertional heart rate response in children with inherited arrhythmic syndromes. In the absence of direct measurement of maximal heart rate, alternative paediatric-specific prediction methods should be developed to ensure appropriate estimation of childhood maximal heart rate. FAU - Renwick, Catherine AU - Renwick C AUID- ORCID: 0000-0003-0193-6137 AD - Royal Brompton & Harefield Hospitals, Guys and St Thomas' NHS Foundation Trust, London, UK. ROR: https://ror.org/00j161312 AD - Institute of Cardiovascular Science, University College London, UK. AD - NIHR, London, UK. ROR: https://ror.org/0187kwz08 FAU - Ogden, Mark AU - Ogden M AUID- ORCID: 0009-0009-3876-7024 AD - Royal Brompton & Harefield Hospitals, Guys and St Thomas' NHS Foundation Trust, London, UK. ROR: https://ror.org/00j161312 FAU - Ramos, Monica AU - Ramos M AD - Royal Brompton & Harefield Hospitals, Guys and St Thomas' NHS Foundation Trust, London, UK. ROR: https://ror.org/00j161312 FAU - Williams, Oliver AU - Williams O AD - Cleveland Clinic London Ltd, UK. FAU - Norrish, Gabrielle AU - Norrish G AD - Institute of Cardiovascular Science, University College London, UK. AD - Inherited Cardiovascular Disease Service, Great Ormond Street Hospital for Children, UK. FAU - Till, Jan AU - Till J AD - Royal Brompton & Harefield Hospitals, Guys and St Thomas' NHS Foundation Trust, London, UK. ROR: https://ror.org/00j161312 FAU - Ware, James AU - Ware J AD - Royal Brompton & Harefield Hospitals, Guys and St Thomas' NHS Foundation Trust, London, UK. ROR: https://ror.org/00j161312 AD - National Heart Lung Institute, Imperial College London, UK. FAU - Kaski, Juan Pablo AU - Kaski JP AUID- ORCID: 0000-0002-0014-9927 AD - Institute of Cardiovascular Science, University College London, UK. AD - Inherited Cardiovascular Disease Service, Great Ormond Street Hospital for Children, UK. LA - eng PT - Journal Article DEP - 20260930 PL - England TA - Cardiol Young JT - Cardiology in the young JID - 9200019 SB - IM OTO - NOTNLM OT - children OT - exercise tolerance testing OT - inherited arrhythmic syndromes OT - maximal heart rate OT - predicted heart rate EDAT- 2026/09/30 11:35 MHDA- 2026/09/30 11:35 CRDT- 2026/09/30 07:13 PHST- 2026/09/30 11:35 [medline] PHST- 2026/09/30 11:35 [pubmed] PHST- 2026/09/30 07:13 [entrez] AID - S1047951126124056 [pii] AID - 10.1017/S1047951126124056 [doi] PST - aheadofprint SO - Cardiol Young. 2026 Sep 30:1-6. doi: 10.1017/S1047951126124056. PMID- 42812512 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260930 LR - 20261001 IS - 1179-1411 (Print) IS - 1179-1411 (Electronic) IS - 1179-1411 (Linking) VI - 18 DP - 2026 TI - Assessing Vaginal Wall Elasticity via Shear-Wave Elastography Using a Transrectal Linear Array High-Frequency Probe in Premenopausal versus Postmenopausal Women: A Cross-Sectional Feasibility Study. PG - 640465 LID - 10.2147/IJWH.S640465 [doi] LID - 640465 AB - OBJECTIVES: This study aims to evaluate the feasibility of transrectal high-frequency linear array shear wave elastography (SWE) for assessing vaginal wall elasticity in women and to investigate potential differences in segmental elasticity values between premenopausal and postmenopausal populations. METHODS: This cross-sectional study included 228 women (164 premenopausal and 64 postmenopausal) who underwent gynecological ultrasound examinations at Hubei Maternal and Child Health Hospital from December 2024 to January 2025. Transrectal linear array high-frequency ultrasound examinations were performed by two ultrasound technicians. Tissue stiffness was assessed using Young's modulus measurements obtained from six standardized vaginal wall segments: upper, middle, and lower regions of both anterior and posterior walls. Inter-rater reliability was assessed by calculating the intraclass correlation coefficient (ICC). RESULTS: Linear mixed-effects modeling adjusting for age and BMI demonstrated that postmenopausal women exhibited significantly higher Young's modulus values (kPa) in the middle anterior wall (14.59 +/- 3.93 vs 12.88 +/- 3.87 kPa; adjusted P = 0.003, FDR q = 0.009) and middle posterior wall (14.87 +/- 4.09 vs 13.28 +/- 4.25 kPa; adjusted P = 0.013, FDR q = 0.026) compared with premenopausal women. Intra-group analysis revealed a significant proximal-to-distal stiffness gradient along the anterior wall in both premenopausal (P < 0.001) and postmenopausal (P = 0.001) groups, whereas the posterior wall displayed spatial homogeneity (P > 0.10). Inter-observer reliability was excellent, with ICCs ranging from 0.83 (0.68-0.94) to 0.95 (0.88-0.98) (P < 0.001). CONCLUSION: Transrectal SWE is a reliable, non-invasive method for evaluating segment-specific vaginal elasticity. Our study showed that postmenopausal tissue stiffening is localized to the middle vaginal canal rather than pan-vaginal, with an anterior proximal-to-distal elasticity gradient. While these findings advance understanding of regional biomechanical specialization, future large-scale, age-matched, and multicenter studies are required to validate these results and establish clinical diagnostic thresholds. CI - (c) 2026 Wu et al. FAU - Wu, Chunxiao AU - Wu C AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Zhou, Si AU - Zhou S AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Xu, Qianqian AU - Xu Q AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Zhao, Sheng AU - Zhao S AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Yang, Juan AU - Yang J AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Gao, Yanduo AU - Gao Y AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Huang, Cheng AU - Huang C AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Qian, Qingqing AU - Qian Q AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. FAU - Zhu, Xia AU - Zhu X AD - Department of Ultrasound Diagnosis, Hubei Maternal and Child Health Hospital, Wuhan, Hubei, 430070, People's Republic of China. LA - eng PT - Journal Article DEP - 20260924 PL - New Zealand TA - Int J Womens Health JT - International journal of women's health JID - 101531698 PMC - PMC13620308 OTO - NOTNLM OT - postmenopausal OT - premenopausal OT - transrectal high-frequency linear array OT - vaginal elasticity COIS- The authors report no conflicts of interest in this work. EDAT- 2026/09/30 11:35 MHDA- 2026/09/30 11:36 PMCR- 2026/09/24 CRDT- 2026/09/30 05:40 PHST- 2026/07/14 00:00 [received] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/09/30 11:36 [medline] PHST- 2026/09/30 11:35 [pubmed] PHST- 2026/09/30 05:40 [entrez] PHST- 2026/09/24 00:00 [pmc-release] AID - 640465 [pii] AID - 10.2147/IJWH.S640465 [doi] PST - epublish SO - Int J Womens Health. 2026 Sep 24;18:640465. doi: 10.2147/IJWH.S640465. eCollection 2026. PMID- 42812397 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261001 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Low nutrition literacy among 4th-5th graders in Chongqing, China: a wake-up call for school health and factors associated with nutrition literacy. PG - 1903177 LID - 10.3389/fpubh.2026.1903177 [doi] LID - 1903177 AB - OBJECTIVE: Despite growing global recognition that nutrition literacy in childhood is a cornerstone of healthy eating and long-term wellbeing, evidence from Chinese primary school settings-particularly from inland, rapidly urbanizing regions-remains scarce. This study aimed to assess the nutrition literacy level of 4th-5th graders in chongqing, china, and to identify its key influencing factors, thereby sounding a wake-up call for school-based health promotion that holds relevance beyond the local context. METHODS: A multistage stratified cluster sampling method was used to conduct a cross-sectional online survey of 1,420 elementary school students in grades 4 and 5 in Chongqing, China. The questionnaire consisted of three sections: demographic characteristics, dietary behaviors, and nutrition literacy levels (Cronbach's alpha = 0.752). Participants were divided into high- and low-scoring groups based on the median nutritional literacy (NL) score. Multiple linear regression analysis was used to identify factors associated with nutrition literacy scores. RESULTS: The mean nutrition literacy score was 65.47 +/- 9.79. In multivariable analysis, older age, female sex, minority ethnicity, urban residence, and higher caregiver educational attainment were independently associated with higher nutrition literacy scores (all P < 0.05). Keeping meal records (beta = 4.18, 95% CI: 2.84-5.51) and participating in meal preparation (beta = 2.07, 95% CI: 1.03-3.12) were also positively associated with nutrition literacy, whereas a meal duration of 31-45 min was negatively associated with nutrition literacy compared with <15 min (beta = -3.39, 95% CI: -5.36 to -1.42). CONCLUSION: Nutrition literacy among 4th-5th grade students in Chongqing was generally low and was associated with both sociodemographic characteristics and dietary behaviors. The findings highlight the importance of strengthening nutrition education and promoting practical food-related activities among school-aged children, with particular attention to children from socioeconomically disadvantaged backgrounds. CI - Copyright (c) 2026 Lan, Deng, Zhou, Luo, Zhang, Ran, Liu, Shi and Zhao. FAU - Lan, Yuanyuan AU - Lan Y AD - School of Public Health, Chongqing Medical University, Chongqing, China. AD - Research Center for Medicine and Social Development, Chongqing Medical University, Chongqing, China. AD - Research Center for Public Health Security, Chongqing Medical University, Chongqing, China. AD - Nutrition Innovation Platform-Sichuan and Chongqing, School of Public Health, Chongqing Medical University, Chongqing, China. FAU - Deng, Jiaxin AU - Deng J AD - School of Public Health, Chongqing Medical University, Chongqing, China. AD - Research Center for Medicine and Social Development, Chongqing Medical University, Chongqing, China. AD - Research Center for Public Health Security, Chongqing Medical University, Chongqing, China. AD - Nutrition Innovation Platform-Sichuan and Chongqing, School of Public Health, Chongqing Medical University, Chongqing, China. FAU - Zhou, Ailin AU - Zhou A AD - School of Public Health, Chongqing Medical University, Chongqing, China. AD - Research Center for Medicine and Social Development, Chongqing Medical University, Chongqing, China. AD - Research Center for Public Health Security, Chongqing Medical University, Chongqing, China. AD - Nutrition Innovation Platform-Sichuan and Chongqing, School of Public Health, Chongqing Medical University, Chongqing, China. FAU - Luo, Yaocheng AU - Luo Y AD - School of Public Health, Chongqing Medical University, Chongqing, China. AD - Research Center for Medicine and Social Development, Chongqing Medical University, Chongqing, China. AD - Research Center for Public Health Security, Chongqing Medical University, Chongqing, China. AD - Nutrition Innovation Platform-Sichuan and Chongqing, School of Public Health, Chongqing Medical University, Chongqing, China. FAU - Zhang, Huiyi AU - Zhang H AD - School of Public Health, Chongqing Medical University, Chongqing, China. AD - Research Center for Medicine and Social Development, Chongqing Medical University, Chongqing, China. AD - Research Center for Public Health Security, Chongqing Medical University, Chongqing, China. AD - Nutrition Innovation Platform-Sichuan and Chongqing, School of Public Health, Chongqing Medical University, Chongqing, China. FAU - Ran, Wenhua AU - Ran W AD - Yuzhong District Primary and Middle School Health Care Center, Chongqing, China. FAU - Liu, Ling AU - Liu L AD - Yuzhong District Primary and Middle School Health Care Center, Chongqing, China. FAU - Shi, Zumin AU - Shi Z AD - Department of Nutrition Sciences, College of Health Sciences, Qatar University, Doha, Qatar. FAU - Zhao, Yong AU - Zhao Y AD - School of Public Health, Chongqing Medical University, Chongqing, China. AD - Research Center for Medicine and Social Development, Chongqing Medical University, Chongqing, China. AD - Research Center for Public Health Security, Chongqing Medical University, Chongqing, China. AD - Nutrition Innovation Platform-Sichuan and Chongqing, School of Public Health, Chongqing Medical University, Chongqing, China. AD - Chongqing Key Laboratory of Child Nutrition and Health, Children's Hospital of Chongqing Medical University, Chongqing, China. LA - eng PT - Journal Article DEP - 20260915 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - China MH - Male MH - Child MH - Cross-Sectional Studies MH - *Health Literacy/statistics & numerical data MH - Surveys and Questionnaires MH - *Students/statistics & numerical data MH - Schools MH - Health Knowledge, Attitudes, Practice PMC - PMC13619951 OTO - NOTNLM OT - health OT - nutrition education OT - nutrition knowledge OT - nutrition literacy OT - school-age children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/30 11:35 MHDA- 2026/09/30 11:36 PMCR- 2026/09/15 CRDT- 2026/09/30 05:23 PHST- 2026/06/08 00:00 [received] PHST- 2026/08/18 00:00 [revised] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/09/30 11:36 [medline] PHST- 2026/09/30 11:35 [pubmed] PHST- 2026/09/30 05:23 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1903177 [doi] PST - epublish SO - Front Public Health. 2026 Sep 15;14:1903177. doi: 10.3389/fpubh.2026.1903177. eCollection 2026. PMID- 42812133 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261007 IS - 1839-2628 (Electronic) IS - 1832-4274 (Linking) VI - 29 IP - 4 DP - 2026 Aug TI - Neonatal Health and Long-Term Outcomes: Twin-Based Evidence From Linked Scandinavian Registers. PG - 323-333 LID - 10.1017/thg.2026.10095 [doi] AB - This study examines the long-term consequences of neonatal health using three birth anthropometric measures - weight, length, and head circumference - and analyzes their differential associations with outcomes across the life course. Using linked Swedish and Norwegian population registers with follow-up into adulthood, we compare birth measures of singletons and twins and further estimate within-twin-pair fixed-effects models that control for shared genetic and family environmental factors. Our samples comprise up to approximately 679,000 singletons and 10,400 twins in Sweden, and 347,841 singletons and 6,762 twins in Norway, followed into adulthood. We find that different birth measures capture distinct aspects of fetal development with varying predictive validity across outcome domains. Birth length emerges as the strongest predictor of health outcomes (infant mortality, adult height), consistent with its role as a cumulative indicator of skeletal growth throughout gestation. Birth weight retains stronger associations with cognitive and educational outcomes (grade point average [GPA], years of schooling) in conditional models. Head circumference shows weak and inconsistent associations across specifications. Using within-pair head circumference differences to classify twins as symmetrically versus asymmetrically growth restricted, we find that symmetric intrauterine growth restriction is associated with substantially worse long-term outcomes than asymmetric restriction. In Norwegian twin pairs, growth restriction is associated with lower general cognitive ability (measured at military enlistment) relative to the unaffected co-twin; this within-pair deficit is more than twice as large for symmetric as for asymmetric restriction. We also document significant intergenerational transmission of birth anthropometrics, suggesting both environmental and genetic contributions. Finally, our register-based design with near-complete population coverage minimizes selection bias and attrition while providing statistical power for within-pair analyses across multiple outcomes. Exclusive reliance on birth weight may obscure important information about early-gestation developmental insults. FAU - Conti, Gabriella AU - Conti G AUID- ORCID: 0000-0003-4699-2490 AD - NHH, Norway. FAU - Buetikofer, Aline AU - Buetikofer A AD - Department of Economics and Social Research Institute, University College London, UK. FAU - Bjorkegren, Evelina AU - Bjorkegren E AD - Stockholm University, Sweden. FAU - Palme, Marten AU - Palme M AD - Stockholm University, Sweden. FAU - Salvanes, Kjell G AU - Salvanes KG AD - Department of Economics and Social Research Institute, University College London, UK. LA - eng PT - Journal Article PT - Twin Study PL - England TA - Twin Res Hum Genet JT - Twin research and human genetics : the official journal of the International Society for Twin Studies JID - 101244624 SB - IM MH - Humans MH - Female MH - *Registries MH - *Birth Weight MH - Infant, Newborn MH - Norway/epidemiology MH - Male MH - Adult MH - Sweden/epidemiology MH - *Infant Mortality MH - *Fetal Development MH - *Twins/genetics MH - Infant MH - Body Height MH - *Twins, Dizygotic/genetics OTO - NOTNLM OT - Birth length OT - Birth weight OT - Fetal origins OT - Head circumference OT - Intrauterine growth restriction OT - Linkage to administrative data OT - Twin studies EDAT- 2026/09/30 05:30 MHDA- 2026/10/06 11:31 CRDT- 2026/09/30 04:24 PHST- 2026/10/06 11:31 [medline] PHST- 2026/09/30 05:30 [pubmed] PHST- 2026/09/30 04:24 [entrez] AID - S1832427426100954 [pii] AID - 10.1017/thg.2026.10095 [doi] PST - ppublish SO - Twin Res Hum Genet. 2026 Aug;29(4):323-333. doi: 10.1017/thg.2026.10095. PMID- 42812016 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261012 IS - 1576-6578 (Electronic) IS - 0210-0010 (Print) IS - 0210-0010 (Linking) VI - 81 IP - 9 DP - 2026 Sep 23 TI - Consensus for the Diagnosis and Treatment of Patients With Spinal Muscular Atrophy (SMA) in Latin America. PG - 53782 LID - 10.31083/RN53782 [doi] LID - 53782 AB - BACKGROUND: 5q spinal muscular atrophy (5q SMA) is an autosomal recessive neuromuscular disorder caused by mutations in the survival motor neuron 1 gene (SMN1), leading to deficiency of SMN protein and a variable clinical spectrum influenced by survival motor neuron 2 gene (SMN2) copy number. The advent of disease-modifying therapies (DMTs) has transformed its clinical course, requiring timely diagnosis, multidisciplinary care, and longitudinal response assessment. In Latin America (LATAM), significant gaps and heterogeneity persist in access to genetic diagnosis, newborn screening, DMTs, and specialized follow-up. To develop a Latin American consensus providing recommendations for diagnosis, comprehensive management (respiratory, swallowing/nutrition, rehabilitation, and DMTs), and evaluation of response to DMTs in patients with SMA, incorporating real-world access considerations. METHODS: A regional expert panel conducted a formal consensus process (2025-2026) through iterative questionnaires and structured discussions. Agreement was defined as >/=70% concordance. Additionally, a regional survey assessed access to diagnostic and therapeutic resources. RESULTS: Forty professionals from 15 countries participated. While 90% reported access to genetic testing (MLPA), only 35% indicated availability within the public healthcare system; private access and pharmaceutical industry support were also reported as pathways to testing. No participating country reported nationwide implementation of newborn screening for SMA; 22.5% of respondents reported pilot programs or future implementation proposals. Access to at least one DMT was reported by 92.5% of respondents; however, delays between diagnosis and treatment initiation were frequent and remain an important challenge across the region. Consensus recommendations were established for diagnosis, functionally stratified multidisciplinary care, and response assessment based on motor and non-motor domains using validated tools and individualized follow-up. CONCLUSIONS: This consensus provides a practical and adaptable framework to optimize SMA care in LATAM, supporting longitudinal, patient-centered clinical decision-making. CI - Copyright: (c) 2026 The Author(s). Published by IMR Press. FAU - Nascimento Osorio, Andres E AU - Nascimento Osorio AE AD - Unidad de Neuromuscular, Hospital Sant Joan de Deu; Group of Applied Research in Neuromuscular Diseases, Institut de Recerca Sant Joan de Deu, 08950 Barcelona, Espana. AD - Center for the Biomedical Research on Rare Diseases (CIBERER), ISCIII, 08036 Barcelona, Espana. FAU - Barros Acevedo, Graciela AU - Barros Acevedo G AD - Centro Hospitalario Pereira Rossell, Instituto de Neurologia, 11600 Montevideo, Uruguay. AD - Teleton Uruguay, 11600 Montevideo, Uruguay. FAU - Beytia, Maria de Los Angeles AU - Beytia MLA AD - Seccion de Neurologia Pediatrica, Division de Pediatria, Escuela de Medicina, Pontificia Universidad Catolica de Chile, 8331150 Santiago, Chile. AD - Unidad de Neurologia Pediatrica, Servicio de Pediatria, Hospital Dr. Sotero del Rio, 8150215 Santiago, Chile. FAU - Bobadilla Quesada, Edna J AU - Bobadilla Quesada EJ AD - Departamento de Pediatria, Fundacion Hospital de la Misericordia (HOMI), 111411 Bogota, Colombia. AD - Hospital Universitario San Ignacio, 110231 Bogota, Colombia. FAU - Castellar-Leones, Sandra M AU - Castellar-Leones SM AD - Departamento de Pediatria, Fundacion Hospital de la Misericordia (HOMI), 111411 Bogota, Colombia. AD - Departamento de Medicina Fisica y Rehabilitacion, Facultad de Medicina, Universidad Nacional de Colombia, 111321 Bogota, Colombia. AD - Hospital Universitario Nacional de Colombia, 111321 Bogota, Colombia. FAU - Castiglioni, Claudia AU - Castiglioni C AD - Departamento de Pediatria, Clinica MEDS, 7510155 Santiago, Chile. AD - Escuela de Medicina, Universidad Finis Terrae, 7501015 Santiago, Chile. FAU - Casartelli Galeano, Marco J AU - Casartelli Galeano MJ AD - Hospital General Pediatrico Ninos de Acosta Nu, Ministerio de Salud Publica y Bienestar Social, 2160 San Lorenzo, Paraguay. FAU - Contreras Caicedo, Guilca AU - Contreras Caicedo G AD - Servicio de Neuropediatria, Centro Medico Docente La Trinidad, 1080 Caracas, Venezuela. FAU - Cordero Molina, Maria Fernanda AU - Cordero Molina MF AD - Neurologia Infantil, Clinica Monte Sinai, 010107 Cuenca, Ecuador. AD - Clinica Latinoamericana, 010107 Cuenca, Ecuador. FAU - Escobar Cedillo, Rosa E AU - Escobar Cedillo RE AD - Instituto Nacional de Rehabilitacion "Luis Guillermo Ibarra Ibarra" (INR-LGII), 14389 Ciudad de Mexico, Mexico. FAU - Espinel, Francisco AU - Espinel F AD - Unidad de Neurologia Pediatrica, Servicio de Pediatria, Hospital Metropolitano, 170135 Quito, Ecuador. FAU - Earle, Nicholas AU - Earle N AD - Departamento de Neurologia y Neurocirugia, Clinica Davila, Santiago, Chile, and Corporacion de Investigacion de Neurologia de Santiago (CINSAN), 8431657 Santiago, Chile. FAU - Franco Tonanez, Carlos A AU - Franco Tonanez CA AD - Departamento de Neuropediatria, Hospital General Pediatrico Ninos de Acosta Nu, 2160 San Lorenzo, Paraguay. FAU - Galvez Quinonez, Henry H AU - Galvez Quinonez HH AD - Centro GALO, 01015 Ciudad de Guatemala, Guatemala. AD - Hospital Regional de Occidente HRO, 09001 Ciudad de Guatemala, Guatemala. FAU - Gurgel-Giannetti, Juliana AU - Gurgel-Giannetti J AD - Department of Pediatrics, Faculdade de Medicina da Universidade Federal de Minas Gerais (UFMG), 30130-100 Belo Horizonte, Brazil. FAU - Gutierrez Mata, Alfonso P AU - Gutierrez Mata AP AD - Hospital Nacional de Ninos de Costa Rica "Dr. Carlos Saenz Herrera", 10101 San Jose, Costa Rica. FAU - Hervias Ruz, Maria C AU - Hervias Ruz MC AD - Neurologia Infantil, Clinica MEDS, 7510155 Santiago, Chile. AD - Escuela de Kinesiologia, Facultad de Medicina, Universidad de los Andes, 7620001 Santiago, Chile. FAU - Linzoain, Javier E AU - Linzoain JE AD - Servicio de Neurologia Pediatrica, Clinica Universitaria Reina Fabiola, X5000 Cordoba, Argentina. AD - Hospital Infantil Municipal de la Ciudad de Cordoba, X5000 Cordoba, Argentina. FAU - Lucero, Mariela A AU - Lucero MA AD - Servicio de Neurologia Infantil, Hospital de Ninos Sor Maria Ludovica, 1900 La Plata, Buenos Aires, Argentina. FAU - Medici, Conrado AU - Medici C AD - Centro Hospitalario Pereira Rossell, Instituto de Neurologia, 11600 Montevideo, Uruguay. FAU - Mesa Restrepo, Sandra C AU - Mesa Restrepo SC AD - Hospital Pablo Tobon Uribe, 050031 Medellin, Colombia. FAU - Meza Cano, Maria E AU - Meza Cano ME AD - Hospital CHRISTUS MUGUERZA Alta Especialidad, 64060 Monterrey, Mexico. AD - Instituto Tecnologico de Monterrey, 64849 Monterrey, Mexico. FAU - Monges, Soledad AU - Monges S AD - Servicio de Neurologia, Hospital de Pediatria S.A.M.I.C. "Prof. Dr. Juan P. Garrahan", 1245 Buenos Aires, Argentina. FAU - Munive Baez, Leticia M AU - Munive Baez LM AD - Servicio de Neurologia, Hospital Medica Sur, 14050 Ciudad de Mexico, Mexico. AD - Instituto Nacional de Pediatria, 04530 Ciudad de Mexico, Mexico. FAU - Nunez Antelo, Lourdes I AU - Nunez Antelo LI AD - VITAE Medicina y Diagnostico, 10260 Santa Cruz de la Sierra, Bolivia. AD - Caja Petrolera de Salud, 10260 Santa Cruz de la Sierra, Bolivia. FAU - Odales Ibarra, Rogelio R AU - Odales Ibarra RR AD - Hospital Pediatrico Baca Ortiz, 170136 Quito, Ecuador. AD - Universidad de las Americas (UDLA), 170125 Quito, Ecuador. FAU - Artiga-Rodriguez, Veronica D AU - Artiga-Rodriguez VD AD - Servicio de Neuropediatria, Hospital Nacional de Ninos Benjamin Bloom, 1101 San Salvador, El Salvador. AD - Clinica Neuroplastickids, 1101 San Salvador, El Salvador. FAU - Perez Almengor, Eva S AU - Perez Almengor ES AD - Hospital del Nino, Dr. Jose Renan Esquivel, 0816-02189 Ciudad de Panama, Panama. FAU - Martinez Esteban, Peggy C AU - Martinez Esteban PC AD - Instituto Nacional de Salud del Nino San Borja, 15036 Lima, Peru. FAU - Ramirez-Montano, Diana AU - Ramirez-Montano D AD - Unidad de Medicina Genomica y Genetica, Clinica Imbanaco Grupo Quiron Salud, 760042 Cali, Colombia. AD - Departamento de Morfologia, Facultad de Salud, Universidad del Valle; Hospital Universitario del Valle Evaristo Garcia ESE, 760032 Cali, Colombia. FAU - Moreno-Salgado, Rodrigo AU - Moreno-Salgado R AD - Fundacion Padrino Todos Santos A.C., 23300 Todos Santos, Baja California Sur, Mexico. FAU - Ruiz Garcia, Matilde AU - Ruiz Garcia M AD - Instituto Nacional de Pediatria, 04530 Ciudad de Mexico, Mexico. FAU - Saez Galaz, Veronica AU - Saez Galaz V AD - Servicio de Neuropsiquiatria Infantil, Hospital Clinico San Borja Arriaran, 8320000 Santiago, Chile. AD - Clinica Universidad de los Andes, 7620001 Santiago, Chile. FAU - Vargas Canas, Edwin S AU - Vargas Canas ES AD - Clinica de Enfermedades Neuromusculares, Instituto Nacional de Neurologia y Neurocirugia "Manuel Velasco Suarez", 14269 Ciudad de Mexico, Mexico. AD - Centro de Neurociencias, Hospital Angeles del Pedregal, 01900 Ciudad de Mexico, Mexico. FAU - Bevilacqua, Jorge A AU - Bevilacqua JA AD - Departamento de Neurologia y Neurocirugia, Clinica Davila, Santiago, Chile, and Corporacion de Investigacion de Neurologia de Santiago (CINSAN), 8431657 Santiago, Chile. AD - Departamento de Neurologia y Neurocirugia, Hospital Clinico Universidad de Chile & Departamento de Anatomia y Medicina Legal, Facultad de Medicina, Universidad de Chile, 8380453 Santiago, Chile. FAU - Zanoteli, Edmar AU - Zanoteli E AD - Department of Neurology, Faculdade de Medicina, Universidade de Sao Paulo (FMUSP), 01246-903 Sao Paulo, Brazil. FAU - Zuniga Garcia, Carol J AU - Zuniga Garcia CJ AD - Hospital Mario Catarino Rivas, Servicio de Neurologia Pediatrica, 21104 San Pedro Sula, Cortes, Honduras. AD - Hospital del Valle, 21102 San Pedro Sula, Cortes, Honduras. FAU - Guecaimburu, Maria R AU - Guecaimburu MR AD - Equipo de Enfermedades Raras, CRENADECER, BPS, 11200 Montevideo, Uruguay. FAU - Gutierrez-Saenz, Mario AU - Gutierrez-Saenz M AD - Neurologia, Hospital Clinica Biblica, 10101 San Jose de Costa Rica, Costa Rica. AD - Caja Costarricense del Seguro Social, 10104 San Jose de Costa Rica, Costa Rica. FAU - Armijo Gomez, Jesus A AU - Armijo Gomez JA AD - Hospital General con Especialidades Juan Maria Salvatierra, 23000 La Paz, Mexico. AD - Neurologia Pediatrica & Patologia Neuromuscular, 23000 La Paz, Mexico. LA - eng LA - spa GR - Roche and Novartis/ PT - Consensus Statement PT - Journal Article TT - Consenso para el Diagnostico y Tratamiento para Pacientes con Atrofia Muscular Espinal (AME) en America Latina. PL - Singapore TA - Rev Neurol JT - Revista de neurologia JID - 7706841 SB - IM MH - Humans MH - Latin America MH - *Muscular Atrophy, Spinal/diagnosis/therapy/genetics MH - Neonatal Screening MH - Genetic Testing PMC - PMC13653183 OTO - NOTNLM OT - Latin America OT - consensus OT - genetic therapy OT - neonatal screening OT - nusinersen OT - risdiplam OT - spinal muscular atrophies of childhood OT - spinal muscular atrophy OT - survival motor neuron 1 gene (SMN1) OT - survival motor neuron 2 gene (SMN2) COIS- Graciela Barros Acevedo, Rogelio R. Odales Ibarra, Maria R. Guecaimburu, Veronica D. Artiga-Rodriguez, Lourdes I. Nunez Antelo, Conrado Medici, Matilde Ruiz Garcia, Carol J. Zuniga Garcia, Maria C. Hervias Ruz, Alfonso P. Gutierrez Mata, Eva S. Perez Almengor, Rosa E. Escobar Cedillo, Maria F. Cordero Molina, Henry H. Galvez Quinonez, Maria de los Angeles Beytia, Maria E. Meza Cano, Carlos A. Franco Tonanez, Guilca Contreras Caicedo, Rodrigo Moreno-Salgado, Veronica Saez Galaz, Edwin S. Vargas Canas, Mario Gutierrez-Saenz, Francisco Espinel, and Nicholas Earle declare that they have no conflicts of interest. EDAT- 2026/09/30 05:30 MHDA- 2026/09/30 05:31 PMCR- 2026/09/23 CRDT- 2026/09/30 04:03 PHST- 2026/05/12 00:00 [received] PHST- 2026/08/03 00:00 [revised] PHST- 2026/08/14 00:00 [accepted] PHST- 2026/09/30 05:31 [medline] PHST- 2026/09/30 05:30 [pubmed] PHST- 2026/09/30 04:03 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - S0210-0010(26)00140-4 [pii] AID - 10.31083/RN53782 [doi] PST - ppublish SO - Rev Neurol. 2026 Sep 23;81(9):53782. doi: 10.31083/RN53782. PMID- 42811996 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20260930 IS - 2768-6698 (Electronic) IS - 2768-6698 (Linking) VI - 31 IP - 9 DP - 2026 Sep 3 TI - Radiotherapy Reconstitutes the Collapsed miRNome of Progressive Neuroblastoma and Promotes a Favorable Tumor Evolutionary Shift. PG - 52737 LID - 10.31083/FBL52737 [doi] AB - BACKGROUND: Progressive disease (PD) remains the dominant barrier to cure in high-risk neuroblastoma (HR-NB), driven in part by profound post-transcriptional deregulation that fuels clonal evolution, stemness, immune evasion, and therapy resistance. In this study, we define the molecular architecture of PD-associated microRNA (miR) collapse and demonstrate that radiotherapy (RT) acts as a potent post-transcriptional reprogrammer capable of reversing this trajectory. METHODS: miRNome profiling was performed in HR-NB tumors from patients during diagnosis (Dx), intensive multi-modal clinical therapy (IMCT) defiant PD, or residual disease after incorporating RT with IMCT (RD-RT). miRs' expression profiles were validated with selective miR-320a, miR-423, miR-483-3p, miR-122-5p, miR-3184-5p, miR-21-5p qPCR. RT-influenced changes in cell-identity were investigated by assessing histomorphological alterations (H&E) and multiplex immunofluorescence (mIF) for Ki-67, PD-L1, SOX2, CD44 or p53. RESULTS: IMCT-defying PD displayed a loss of 167 miRs, and none upregulated, corresponding an evolutionary fingerprint for pathways governing cancer stem cell (CSC) maintenance, epithelial to mesenchymal transition (EMT), metabolic rewiring, proliferative fitness, and immune suppression. Strikingly, adding RT reversed 146 of these miRs and induced additional 179 RT-specific miRs, restoring regulatory networks governing apoptosis, p53-mediated DNA-damage response, differentiation/mesenchymal to epithelial transition (MET), and immune visibility. Individual miR-qPCR analysis of miR-320a, miR-483-3p, miR-3184-5p miR-21-5p, and miR-122-5p validated and corroborated the array expression outcomes. Histologic and mIF remarkably substantiated these miR signatures, showing that RT transforms poorly differentiated, plastic, PD-L1(+)/SOX2(+)/CD44(+) CSC-like PD tumors into differentiated, lineage-stabilized, immune-permissive states characterized by neuropil restoration, ganglioneuroma-like maturation, marginal yet measurable loss of SOX2/CD44, suppression of PD-L1, complete collapse of Ki-67(+) proliferative compartments, and significant induction of p53. CONCLUSION: Collectively, our findings indicated that RT could be a global regulator of tumor state transitions, reinstating miR-mediated governance lost during PD evolution and redirecting tumor fate toward regression. Our results provide proof-of-concept evidence that RT delivers powerful molecular benefits beyond local control, introducing a conceptual framework for miR-guided RT personalization, biomarker development, and rational combination strategies to improve outcomes in HR-NB. CI - Copyright: (c) 2026 The Author(s). Published by IMR Press. FAU - Narayanan, Sivasubramani AU - Narayanan S AD - Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA. FAU - Subramanian, Poorvi AU - Subramanian P AD - Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA. FAU - Mohanvelu, Sreenidhi AU - Mohanvelu S AD - Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA. FAU - Aravindan, Sheeja AU - Aravindan S AD - OU Health Stephenson Cancer Center, Oklahoma City, OK 73104, USA. FAU - Periyasamy, Loganayaki AU - Periyasamy L AD - Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA. FAU - Aravindan, Natarajan AU - Aravindan N AD - Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA. AD - OU Health Stephenson Cancer Center, Oklahoma City, OK 73104, USA. AD - Departments of Radiation Oncology and Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA. LA - eng GR - DoD CA-210339/Department of Defense/ GR - NIH-P30GM154635/NH/NIH HHS/United States GR - OCAST-HR19-045/Oklahoma Center for the Advancement of Science and Technology/ GR - P30CA225520/NIH-NCI- Cancer Center Support Grant/ PT - Journal Article PL - Singapore TA - Front Biosci (Landmark Ed) JT - Frontiers in bioscience (Landmark edition) JID - 101612996 RN - 0 (MicroRNAs) SB - IM MH - Humans MH - *Neuroblastoma/genetics/radiotherapy/pathology MH - *MicroRNAs/genetics MH - Gene Expression Regulation, Neoplastic/radiation effects MH - Disease Progression MH - Neoplastic Stem Cells/radiation effects/metabolism/pathology MH - Female MH - Gene Expression Profiling MH - Epithelial-Mesenchymal Transition/genetics MH - Male MH - Infant OTO - NOTNLM OT - disease progression OT - high-risk neuroblastoma OT - microRNAs OT - neoplastic cell transformation OT - radiotherapy COIS- The authors declare no conflicts of interest. Given his role as the Guest Editor, Natarajan Aravindan had no involvement in the peer-review of this article and has no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to Amancio Carnero Moya. EDAT- 2026/09/30 05:30 MHDA- 2026/09/30 05:31 CRDT- 2026/09/30 03:44 PHST- 2026/04/09 00:00 [received] PHST- 2026/07/10 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/09/30 05:31 [medline] PHST- 2026/09/30 05:30 [pubmed] PHST- 2026/09/30 03:44 [entrez] AID - S2768-6701(26)02241-0 [pii] AID - 10.31083/FBL52737 [doi] PST - ppublish SO - Front Biosci (Landmark Ed). 2026 Sep 3;31(9):52737. doi: 10.31083/FBL52737. PMID- 42811307 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261006 IS - 1471-2334 (Electronic) IS - 1471-2334 (Linking) VI - 26 IP - 1 DP - 2026 Aug 10 TI - Diagnostic performance of a centrifugation-free stool processing kit in conjunction with Xpert((R))MTB/RIF Ultra for paediatric tuberculosis: a multicentre prospective study in five low and middle-income countries. LID - 10.1186/s12879-026-13902-6 [doi] LID - 1736 AB - INTRODUCTION: Diagnosing paediatric tuberculosis (TB) remains challenging. Currently available diagnostic tests have limited accuracy, and most sampling methods are invasive. In 2021, the World Health Organization (WHO) endorsed the use of molecular WHO-recommended rapid diagnostic tests (mWRDs) with stool as an initial diagnostic tool for paediatric TB. In this study, we evaluated the diagnostic test accuracy (DTA) of stool samples processed with the Stool Processing Kit (SPK), one of three centrifugation-free methods available at the time. METHODS: We conducted a multi-centre prospective diagnostic validation study in South Africa, Tanzania, Malawi, Mozambique, and India. Children (< 15 years) under investigation for TB provided at least two (induced) sputum samples at enrolment, one stool sample, and one nasopharyngeal aspirate (NPA) if aged < 5 years and a chest x-ray. TB testing included Xpert((R)) MTB/RIF Ultra (Ultra) and culture. Diagnostic classification followed NIH consensus statements. Stool samples were processed using the SPK and tested with Ultra. We calculated DTA in the overall cohort and predefined subgroups of interest. RESULTS: Out of 5313 children screened, 975 were enrolled, and data from 817 children recruited between January 2019 and June 2021 were analysed. The overall microbiological confirmation rate was 203/817 (24.9%), and an additional 358/817 (43.8%) were classified as unconfirmed TB and 256/817 (31.3%) were classified as unlikely TB. The median age was 5.3 years (IQR: 2.0-9.2), and 390/817 (47.7%) of participants were under the age of five. 134/817 (16.4%) of children were living with HIV, and 88/817 (10.8%) had severe acute malnutrition (SAM). The overall sensitivity and specificity of SPK/Ultra against a Strict Reference Standard (SRS) were 33.8% (95% CI: 27.6-40.6) and 86.8% (95% CI: 80.5-91.3), respectively. Among children under one year of age and those with SAM, sensitivity was 43.3% (95% CI: 27.4-60.8) and 41.4% (95% CI: 25.5-59.3), respectively, with specificity reaching 100% in young children and 85% (95% CI: 64.0-94.8) in children with SAM. Classic TB symptoms and chest X-ray abnormalities at baseline were associated with increased likelihood of SPK/Ultra positivity. CONCLUSIONS: This is one of the largest studies to evaluate stool as an alternative specimen for diagnosing paediatric TB. Although the WHO's target product profile was not fully met, stool testing with SPK/Ultra represents a viable alternative to invasive sampling methods, especially in subgroups of interest. TRIAL REGISTRATION: ClinicalTrials.gov, NCT03734172, June 22, 2018. CI - (c) 2026. The Author(s). FAU - Banze, Denise AU - Banze D AD - Instituto Nacional de Saude (INS), Marracuene, Mozambique. denise.banze@ins.gov.mz. AD - CIH LMU Center for International Health, University Hospital, LMU Munich, Munich, Germany. denise.banze@ins.gov.mz. FAU - Olbrich, Laura AU - Olbrich L AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. AD - Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, Munich, Germany. FAU - Razid, Alia AU - Razid A AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. AD - Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Pettenkofer School of Public Health, Munich, Germany. FAU - Franckling-Smith, Zoe AU - Franckling-Smith Z AD - Department of Paediatrics & Child Health, SA-MRC Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa. FAU - Mfinanga, Alfred AU - Mfinanga A AD - CIH LMU Center for International Health, University Hospital, LMU Munich, Munich, Germany. AD - National Institute for Medical Research - Mbeya Medical Research Centre, Mbeya, Tanzania. FAU - Ntinginya, Nyanda Elias AU - Ntinginya NE AD - National Institute for Medical Research - Mbeya Medical Research Centre, Mbeya, Tanzania. FAU - Sabi, Issa AU - Sabi I AD - National Institute for Medical Research - Mbeya Medical Research Centre, Mbeya, Tanzania. AD - Department of Paediatric and Child Health, School of Medicine and Dentistry, University of Dodoma, Dodoma, Tanzania. FAU - Nliwasa, Marriot AU - Nliwasa M AD - TB/HIV Research Group, College of Medicine, Blantyre, Malawi. FAU - Semphere, Robina AU - Semphere R AD - TB/HIV Research Group, College of Medicine, Blantyre, Malawi. FAU - Corbett, Elizabeth L AU - Corbett EL AD - TB/HIV Research Group, College of Medicine, Blantyre, Malawi. AD - TB Center, London School of Hygiene and Tropical Medicine, London, UK. FAU - Michael, Joy Sarojini AU - Michael JS AD - Clinical Microbiology, Christian Medical College, Vellore, India. FAU - Verghese, Valsan Philip AU - Verghese VP AD - Pediatric Infectious Diseases, Christian Medical College, Vellore, India. FAU - Graham, Stephen M AU - Graham SM AD - Department of Paediatrics and Department of Respiratory Medicine, Royal Children's Hospital, University of Melbourne, Melbourne, Australia. FAU - Nabeta, Pamela AU - Nabeta P AD - Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland. FAU - Trollip, Andre AU - Trollip A AD - Foundation for Innovative New Diagnostics (FIND), Geneva, Switzerland. FAU - Song, Rinn AU - Song R AD - Oxford Vaccine Group, Department of Paediatrics, and the NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK. FAU - Larsson, Leyla AU - Larsson L AD - Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK. FAU - Geldmacher, Christof AU - Geldmacher C AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. FAU - Hoelscher, Michael AU - Hoelscher M AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. FAU - Zar, Heather J AU - Zar HJ AD - Department of Paediatrics & Child Health, SA-MRC Unit on Child & Adolescent Health, University of Cape Town, Cape Town, South Africa. FAU - Viegas, Sofia AU - Viegas S AD - Instituto Nacional de Saude (INS), Marracuene, Mozambique. FAU - Heinrich, Norbert AU - Heinrich N AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, LMU Munich, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. AD - Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Immunology, Infection and Pandemic Research, Munich, Germany. FAU - Khosa, Celso AU - Khosa C AD - Instituto Nacional de Saude (INS), Marracuene, Mozambique. AD - Department of International Public Health and Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK. AD - Universidade Eduardo Mondlane, Maputo, Mozambique. LA - eng SI - ClinicalTrials.gov/NCT03734172 GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ GR - RIA2016MC-1623 - RaPaed TB/European & Developing Countries Clinical Trials Partnership/ PT - Clinical Trial PT - Journal Article PT - Multicenter Study DEP - 20260810 PL - England TA - BMC Infect Dis JT - BMC infectious diseases JID - 100968551 SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - *Feces/microbiology MH - India MH - Malawi MH - *Molecular Diagnostic Techniques/methods MH - Mozambique MH - Mycobacterium tuberculosis/isolation & purification/genetics MH - Prospective Studies MH - Rapid Diagnostic Tests MH - Sensitivity and Specificity MH - South Africa MH - *Specimen Handling/methods MH - Sputum/microbiology MH - Tanzania MH - *Tuberculosis/diagnosis/microbiology MH - *Developing Countries PMC - PMC13621693 OTO - NOTNLM OT - Child* OT - Diagnostics OT - Stool OT - Tuberculosis OT - mWRDs COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Ethics Committee of the Faculty of Medicine at Ludwig-Maximilians-University Munich, Germany; the University of Cape Town, Faculty of Health Sciences, Human Research Ethics Committee, South Africa; the Mbeya Medical Research and Ethics Committee, Tanzania; the Ministerio da Saude, Comite Nacional de Bioetica para a Saude, Mozambique; the College of Medicine Research and Ethics Committee (COMREC), Malawi; and the Office of Research Institutional Review Board, Christian Medical College, Vellore, India. The study was conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from caregivers or legal guardians of all participants, and assent was obtained from children in accordance with local ethical guidelines. Consent for publication: Consent for publication: Not applicable. This manuscript does not include any individual person's data in an identifiable form (including images). All data are presented in aggregate and/or de-identified. Competing interests: All authors have received funding from the European & Developing Countries Clinical Trials Partnership (EDCTP) to their respective institutions. Cepheid provided testing kits at no cost. EDAT- 2026/09/30 05:30 MHDA- 2026/09/30 05:31 PMCR- 2026/08/10 CRDT- 2026/09/29 23:53 PHST- 2025/12/26 00:00 [received] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/09/30 05:31 [medline] PHST- 2026/09/30 05:30 [pubmed] PHST- 2026/09/29 23:53 [entrez] PHST- 2026/08/10 00:00 [pmc-release] AID - 10.1186/s12879-026-13902-6 [pii] AID - 13902 [pii] AID - 10.1186/s12879-026-13902-6 [doi] PST - epublish SO - BMC Infect Dis. 2026 Aug 10;26(1):1736. doi: 10.1186/s12879-026-13902-6. PMID- 42810158 OWN - NLM STAT- Publisher LR - 20260929 IS - 1873-5487 (Electronic) IS - 0188-4409 (Linking) VI - 58 IP - 1 DP - 2026 Sep 29 TI - Strengthening the Socio-cultural Dimension of Food in the Mexican Healthy and Sustainable Dietary Guidelines. PG - 103531 LID - S0188-4409(26)00153-0 [pii] LID - 10.1016/j.arcmed.2026.103531 [doi] AB - BACKGROUND: Dietary guidelines should incorporate not only advances in nutritional science but also the sociocultural factors that shape food practices. This study describes how the sociocultural dimension was integrated into the 2023 Mexican Healthy and Sustainable Dietary Guidelines (HSDGs). It presents key formative research findings on food practices, perceptions, and the sociocultural and environmental factors influencing adherence to selected dietary recommendations, which informed the contextualization, formulation, and communication of the Guidelines. METHODS: We conducted 84 semi-structured interviews with mothers and fathers of children and adolescents from low socioeconomic households across Mexico. Interviews explored food practices, the sociocultural food space, the feasibility of adopting selected dietary recommendations, and environmental practices related to food consumption. RESULTS: Social norms, symbolic meanings, gendered food responsibilities, and food environment factors strongly influenced dietary practices. Prevailing norms encouraged the consumption of red meat and ultra-processed products while discouraging vegetables and legumes, creating barriers to healthier and more sustainable diets. CONCLUSIONS: These findings informed recommendations to reshape food-related social norms by promoting vegetables and legumes as everyday foods, challenging the normalization of frequent red meat and ultra-processed product consumption, encouraging shared household food responsibilities, and addressing structural barriers such as the seasonal affordability of fruits and vegetables. CI - Copyright (c) 2026 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc. All rights reserved. FAU - Theodore, Florence L AU - Theodore FL AD - Centro de Investigacion en Nutricion y Salud, Instituto Nacional de Salud Publica, Cuernavaca, Mexico. FAU - Pacheco-Miranda, Selene AU - Pacheco-Miranda S AD - Centro de Investigacion en Nutricion y Salud, Instituto Nacional de Salud Publica, Cuernavaca, Mexico. FAU - Venosa-Lopez, Monica AU - Venosa-Lopez M AD - Centro de Investigacion en Nutricion y Salud, Instituto Nacional de Salud Publica, Cuernavaca, Mexico. FAU - Franco-Salazar, Mariel Andrea AU - Franco-Salazar MA AD - Centro de Investigacion en Nutricion y Salud, Instituto Nacional de Salud Publica, Cuernavaca, Mexico. FAU - Gaxiola, Ana Cecilia AU - Gaxiola AC AD - Centro de Investigacion en Nutricion y Salud, Instituto Nacional de Salud Publica, Cuernavaca, Mexico. FAU - Molina-Barrera, Veronika AU - Molina-Barrera V AD - Consultant to the UN Food and Agriculture Organization. FAU - Brero, Mauro AU - Brero M AD - Consultant for Food and Agriculture Organization of the United Nations Head of Nutrition at the United Nations Children's Fund. FAU - Bonvecchio, Anabelle AU - Bonvecchio A AD - Consultant for Food and Agriculture Organization of the United Nations Head of Nutrition at the United Nations Children's Fund. Electronic address: bonvecchio@insp.mx. LA - eng PT - Journal Article DEP - 20260929 PL - United States TA - Arch Med Res JT - Archives of medical research JID - 9312706 SB - IM OTO - NOTNLM OT - Dietary guidelines OT - Food culture OT - Food environment OT - Formative research OT - Qualitative methodology EDAT- 2026/09/29 23:29 MHDA- 2026/09/29 23:29 CRDT- 2026/09/29 18:19 PHST- 2025/09/19 00:00 [received] PHST- 2026/06/15 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/09/29 23:29 [medline] PHST- 2026/09/29 23:29 [pubmed] PHST- 2026/09/29 18:19 [entrez] AID - S0188-4409(26)00153-0 [pii] AID - 10.1016/j.arcmed.2026.103531 [doi] PST - aheadofprint SO - Arch Med Res. 2026 Sep 29;58(1):103531. doi: 10.1016/j.arcmed.2026.103531. PMID- 42809924 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261024 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 205 DP - 2026 Dec TI - Age- and sex-specific CT reference trajectories for abdominal organ volumes and attenuation: a large-scale automated analysis. PG - 113247 LID - S0720-048X(26)00595-4 [pii] LID - 10.1016/j.ejrad.2026.113247 [doi] AB - BACKGROUND: Reference values for adult abdominal organ volumes and attenuation remain limited, although they are important for accurate CT interpretation and opportunistic imaging assessment. METHODS: This retrospective cross-sectional study included 25,161 abdominal CT examinations from 15,408 adult patients aged 18-100 years, comprising 5,559 women, 9,848 men, and one non-binary patient. Attenuation measurements were derived from the unenhanced phase available in 9,548 examinations. Organ volumes and attenuation values were quantified using a fully automated segmentation pipeline (TotalSegmentator). Percentile reference curves (P3-P97) were generated using generalized additive models for location, scale, and shape (GAMLSS). RESULTS: Men had higher organ volumes than women across nearly all organs and age groups. Age-group-averaged model-derived P50 estimates showed organ-specific trajectories: liver, pancreas, and kidney volumes followed an inverted U-shaped pattern, increasing from young adulthood to midlife and declining thereafter. Liver volume peaked in midlife and declined thereafter, rising from 1,303.1 to 1,450.2 mL in women and from 1,560.7 to 1,774.1 mL in men, before decreasing to 1,019.6 and 1,234.9 mL at 90-100 years, respectively. Pancreatic volume peaked at 40-49 years (67.7 mL in women; 86.2 mL in men) and declined to 35.5/46.4 mL. Right/left kidney volumes increased from 115.6/126.6 to 138.2/143.2 mL in women and from 154.6/163.4 to 179.4/183.3 mL in men, before declining to 87.8/84.5 and 113.1/112.8 mL, respectively. Spleen volume decreased overall with age, whereas adrenal volume increased into later adulthood. Organ attenuation generally declined with age, most markedly in the pancreas and adrenal glands. CONCLUSION: Percentile-based trajectories derived from large-scale automated CT analysis provide descriptive reference values for abdominal organ volume and attenuation across adulthood. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Reschke, Philipp AU - Reschke P AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. Electronic address: Philipp.reschke@outlook.de. FAU - Booz, Christian AU - Booz C AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Koch, Vitali AU - Koch V AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Gotta, Jennifer AU - Gotta J AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Hohne, Elena AU - Hohne E AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Martin, Simon S AU - Martin SS AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Yel, Ibrahim AU - Yel I AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Mahmoudi, Scherwin AU - Mahmoudi S AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Bernatz, Simon AU - Bernatz S AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Nica, Andreea I AU - Nica AI AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Gulli, Claudia AU - Gulli C AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany; Diagnostic and Interventional Radiology Unit, Department of Dental and Morphological and Functional Imaging, University Hospital Messina, Messina, Italy. FAU - D'Angelo, Tommaso AU - D'Angelo T AD - Diagnostic and Interventional Radiology Unit, Department of Dental and Morphological and Functional Imaging, University Hospital Messina, Messina, Italy. FAU - Gruber-Rouh, Tatjana AU - Gruber-Rouh T AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Eichler, Katrin AU - Eichler K AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Vogl, Thomas J AU - Vogl TJ AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. FAU - Gruenewald, Leon D AU - Gruenewald LD AD - Goethe University Hospital Frankfurt, Department of Diagnostic and Interventional Radiology, Clinic for Radiology and Nuclear Medicine, 60590 Frankfurt am Main, Germany. LA - eng PT - Journal Article DEP - 20260912 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 SB - IM MH - Humans MH - Male MH - Female MH - *Tomography, X-Ray Computed/statistics & numerical data/standards MH - Reference Values MH - Adolescent MH - Organ Size/physiology MH - Middle Aged MH - Aged MH - Adult MH - Aged, 80 and over MH - *Radiography, Abdominal/statistics & numerical data/standards MH - Reproducibility of Results MH - Young Adult MH - Sensitivity and Specificity MH - *Aging/physiology MH - Age Distribution MH - *Pattern Recognition, Automated/methods MH - Sex Distribution MH - *Radiographic Image Interpretation, Computer-Assisted/methods MH - *Imaging, Three-Dimensional/standards/statistics & numerical data MH - Retrospective Studies MH - *Viscera/diagnostic imaging COIS- Declaration of competing interest Christian Booz received speaking fees from Siemens Healthineers. Ibrahim Yel received a speaking fee from Siemens Healthineers. The other authors have no potential conflict of interest to disclose. EDAT- 2026/09/29 23:29 MHDA- 2026/10/24 05:34 CRDT- 2026/09/29 18:02 PHST- 2026/03/31 00:00 [received] PHST- 2026/07/15 00:00 [revised] PHST- 2026/09/11 00:00 [accepted] PHST- 2026/10/24 05:34 [medline] PHST- 2026/09/29 23:29 [pubmed] PHST- 2026/09/29 18:02 [entrez] AID - S0720-048X(26)00595-4 [pii] AID - 10.1016/j.ejrad.2026.113247 [doi] PST - ppublish SO - Eur J Radiol. 2026 Dec;205:113247. doi: 10.1016/j.ejrad.2026.113247. Epub 2026 Sep 12. PMID- 42809284 OWN - NLM STAT- MEDLINE DCOM- 20260929 LR - 20261002 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 9 IP - 9 DP - 2026 Sep 1 TI - Prevalence of Overweight and Obesity Among Children Younger Than 5 Years in India. PG - e2636750 LID - 10.1001/jamanetworkopen.2026.36750 [doi] LID - e2636750 AB - IMPORTANCE: Evidence is lacking on long-term trends across Indian states and union territories (UTs) and on the attainability of the 2030 Global Nutrition Target (GNT) goals within these specific regions. OBJECTIVES: To estimate the trends in overweight and obesity among children younger than 5 years across 36 states and UTs in India between 2006 and 2024 and to assess the feasibility of achieving the GNT of restricting the overweight burden to 5% or less by 2030. DESIGN, SETTING, AND PARTICIPANTS: For this cross-sectional study, microdata and aggregate data were used from the 4 most recent waves of the National Family Health Survey (repeated cross-sectional surveys conducted between January 1, 2006, and December 31, 2024). The analysis included individual-level samples of 41 306 children in 2006, 225 002 in 2016, and 201 687 in 2021, alongside aggregate estimates of overweight from the 2024 wave. Data were analyzed in January and updated in July 2026. MAIN OUTCOMES AND MEASURES: Following World Health Organization definitions of overweight and obesity in children younger than 5 years (overweight is defined as weight for height >2 SDs above the World Health Organization median and obesity as >3 SDs), their prevalence and standardized annualized changes for 5 timeframes (2006-2016, 2016-2021, 2021-2024, 2006-2021, and 2006-2024) were computed. Additionally, the fractional logistic regression was used to model national and state-level overweight trajectories, forecasting probability of achieving the 5% or less 2030 GNT threshold. RESULTS: The final sample included 467 995 children (241 645 [51.6%] male, 226 350 [48.4%] female) aged 0 to 59 months from NFHSs conducted between 2006 and 2021. Mean (SD) child age remained consistent from 2006 to 2021: 30.1 (17.1) months in 2006, 30.1 (17.0) months in 2016, and 29.9 (17.2) months in 2021. Between 2006 and 2021, the prevalence of overweight increased from 1.55% to 3.42%, whereas obesity prevalence increased from 0.50% to 1.30% before overweight prevalence decreased to 1.3% in 2024. Although India was projected to sustain the 2030 overweight target nationally, 9 states and UTs (Arunachal Pradesh, Assam, Himachal Pradesh, Jammu and Kashmir, Kerala, Mizoram, Nagaland, Sikkim, and Tripura) maintained a low to moderate probability of adherence. CONCLUSIONS AND RELEVANCE: In this cross-sectional study of Indian children younger than 5 years from 2006 to 2024, a historical overweight increase reversed in 2024. However, profound subnational disparities remained, suggesting that targeted regional interventions are needed to achieve the 2030 GNT. FAU - Rai, Rajesh Kumar AU - Rai RK AD - Division of Global Health Management and Policy, School of Public Health, San Diego State University, San Diego, California. AD - Birbhum Population Project, Society for Health and Demographic Surveillance, Suri, West Bengal, India. AD - ImplactLoop Ltd, London, UK. AD - Human Nutrition Unit, Institute of Nutrition, Mahidol University, Phutthamonthon, Nakhon Pathom, Thailand. AD - Department of Global Health and Population, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. FAU - Matsuzaki, Mika AU - Matsuzaki M AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. AD - Center for Human Nutrition, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. AD - Community Nutrition Unit, Institute of Nutrition, Mahidol University, Phutthamonthon, Nakhon Pathom, Thailand. FAU - De Neve, Jan-Walter AU - De Neve JW AD - Division of Global Health Management and Policy, School of Public Health, San Diego State University, San Diego, California. AD - Heidelberg Institute of Global Health, Faculty of Medicine and University Hospital, University of Heidelberg, Heidelberg, Germany. FAU - Zafar, Sumaira AU - Zafar S AD - Community Nutrition Unit, Institute of Nutrition, Mahidol University, Phutthamonthon, Nakhon Pathom, Thailand. FAU - Bromage, Sabri AU - Bromage S AD - Community Nutrition Unit, Institute of Nutrition, Mahidol University, Phutthamonthon, Nakhon Pathom, Thailand. AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. FAU - Kim, Rockli AU - Kim R AD - Division of Health Policy and Management, College of Health Science, Korea University, Seoul, South Korea. AD - Interdisciplinary Program in Precision Public Health, Department of Public Health Sciences, Graduate School of Korea University, Seoul, South Korea. FAU - Subramanian, S V AU - Subramanian SV AD - Harvard Center for Population and Development Studies, Cambridge, Massachusetts. AD - Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. LA - eng PT - Journal Article DEP - 20260901 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Humans MH - India/epidemiology MH - Child, Preschool MH - Male MH - Cross-Sectional Studies MH - Female MH - Prevalence MH - Infant MH - *Overweight/epidemiology MH - *Pediatric Obesity/epidemiology PMC - PMC13624874 COIS- Conflict of Interest Disclosures: None reported. EDAT- 2026/09/29 19:04 MHDA- 2026/09/29 19:05 PMCR- 2026/09/29 CRDT- 2026/09/29 11:32 PHST- 2026/09/29 19:05 [medline] PHST- 2026/09/29 19:04 [pubmed] PHST- 2026/09/29 11:32 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - 2854611 [pii] AID - zoi260985 [pii] AID - 10.1001/jamanetworkopen.2026.36750 [doi] PST - epublish SO - JAMA Netw Open. 2026 Sep 1;9(9):e2636750. doi: 10.1001/jamanetworkopen.2026.36750. PMID- 42809071 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261029 IS - 1708-0428 (Electronic) IS - 0960-8923 (Linking) VI - 36 IP - 11 DP - 2026 Nov TI - Development and Validation of a Machine Learning Model for Predicting One-year Anemia After Bariatric Surgery: A Multicenter Study. PG - 5595-5606 LID - 10.1007/s11695-026-08965-y [doi] AB - INTRODUCTION: Anemia is a common nutritional complication after bariatric surgery, but preoperative tools for individualized risk assessment remain limited. This study aims to develop and externally validate a machine learning model for predicting anemia status one year after bariatric surgery. METHODS: This multicenter study included patients aged 16-65 years undergoing sleeve gastrectomy or Roux-en-Y gastric bypass. Patients from one hospital formed the derivation cohort, and patients from two independent hospitals formed the external validation cohort. Forty-five preoperative variables were evaluated using logistic regression, random forest, support vector machine, and extreme gradient boosting. Model discrimination, calibration, and clinical utility were assessed and compared with blinded predictions from 10 clinicians with different levels of experience. RESULTS: The derivation cohort included 511 patients (409 training, 102 internal testing), and the external cohort included 300 patients. One-year anemia occurred in 39.6%, 39.2%, and 19.0% of patients in the training, testing, and external validation cohorts, respectively. Random forest showed the most favorable overall performance profile and was simplified to seven predictors. The final model achieved an area under the curve of 0.827 (95% CI, 0.746-0.896) in the testing set and 0.823 (95% CI, 0.771-0.873) in the external validation cohort, with satisfactory calibration and decision-curve net benefit. In external validation, the model outperformed junior, middle-level, and senior clinicians and remained superior in clinician-defined challenging cases. CONCLUSIONS: A seven-variable preoperative model showed good discrimination for one-year anemia status after bariatric surgery and may support individualized postoperative monitoring and nutritional care. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Nie, Yuntao AU - Nie Y AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Wang, Tianshi AU - Wang T AD - Department of General Surgery, Second Hospital of Shandong University, Jinan, China. FAU - Tang, Haibo AU - Tang H AD - Department of General Surgery, Third Xiangya Hospital, Changsha, China. FAU - Huang, Yishan AU - Huang Y AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Wang, Zhe AU - Wang Z AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Wang, Pengpeng AU - Wang P AUID- ORCID: 0000-0002-0161-1933 AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Wang, Siqi AU - Wang S AUID- ORCID: 0000-0001-9401-0880 AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Liu, Genzheng AU - Liu G AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Lin, Ximing AU - Lin X AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Ran, Shuman AU - Ran S AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Liu, Yan AU - Liu Y AD - Department of Gastrointestinal Metabolic Surgery, Zhengzhou Central Hospital, Zhengzhou, China. FAU - Zhu, Ming AU - Zhu M AD - Department of Gastrointestinal Surgery, Jining First People's Hospital, Jining, China. FAU - Hu, Jingwei AU - Hu J AD - Department of Gastrointestinal Surgery, Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. FAU - Li, Chunhui AU - Li C AD - Department of Endocrinology, Second Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Zhang, Nianrong AU - Zhang N AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Liu, Baoyin AU - Liu B AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. FAU - Zhu, Liyong AU - Zhu L AUID- ORCID: 0000-0002-4666-8458 AD - Department of General Surgery, Third Xiangya Hospital, Changsha, China. zly8128@csu.edu.cn. FAU - Ding, Yinlu AU - Ding Y AD - Department of General Surgery, Second Hospital of Shandong University, Jinan, China. dingyinlu@126.com. FAU - Meng, Hua AU - Meng H AD - Department of General Surgery & Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, China. menghua@zryhyy.com.cn. LA - eng PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20260929 PL - United States TA - Obes Surg JT - Obesity surgery JID - 9106714 SB - IM MH - Humans MH - *Anemia/etiology/epidemiology/diagnosis MH - Female MH - Middle Aged MH - Adult MH - Predictive Learning Models MH - *Machine Learning MH - Male MH - Adolescent MH - *Postoperative Complications/etiology/epidemiology MH - *Bariatric Surgery/adverse effects MH - Random Forest MH - *Obesity, Morbid/surgery MH - Aged MH - Young Adult MH - Risk Assessment MH - Classification Algorithms MH - Prediction Algorithms MH - Boosting Machine Learning Algorithms MH - *Gastric Bypass/adverse effects MH - Gastrectomy/adverse effects OTO - NOTNLM OT - Bariatric surgery OT - Machine learning OT - Postoperative anemia OT - Prediction model COIS- Declarations. Ethical Approval: This study was conducted in accordance with the Helsinki Declaration and approved by the IRB of Hospital 1 (approval number blinded for peer review). Informed Consent: The requirement for informed consent was waived. Competing interests: The authors declare no competing interests. EDAT- 2026/09/29 19:04 MHDA- 2026/10/27 17:29 CRDT- 2026/09/29 11:12 PHST- 2026/06/25 00:00 [received] PHST- 2026/09/26 00:00 [accepted] PHST- 2026/09/15 00:00 [revised] PHST- 2026/10/27 17:29 [medline] PHST- 2026/09/29 19:04 [pubmed] PHST- 2026/09/29 11:12 [entrez] AID - 10.1007/s11695-026-08965-y [pii] AID - 10.1007/s11695-026-08965-y [doi] PST - ppublish SO - Obes Surg. 2026 Nov;36(11):5595-5606. doi: 10.1007/s11695-026-08965-y. Epub 2026 Sep 29. PMID- 42808984 OWN - NLM STAT- Publisher LR - 20260929 IS - 1935-5548 (Electronic) IS - 0149-5992 (Linking) DP - 2026 Sep 29 TI - Insulin Dose-Adjusted Hemoglobin A1c Has Suboptimal Performance for Identifying C-Peptide-Defined Partial Remission: The SEARCH for Diabetes in Youth Study. LID - dc261313 [pii] LID - 10.2337/dc26-1313 [doi] AB - OBJECTIVE: Insulin dose-adjusted hemoglobin A1c (IDAA1c = HbA1c [%] + [4 x total daily dose in units/kg/day]) /=85th percentile [overweight or obese]) using Wilcoxon rank sum and Fisher exact tests. Sensitivity, specificity, and receiver operating characteristic (ROC) AUC of IDAA1c /=0.91 ng/mL with an ROC AUC of 0.77. Among participants with overweight or obesity, sensitivity was 45% and specificity 81%. A Youden index-derived cutoff of IDAA1c 0.05). Higher PDI scores were associated with modestly lower odds of WHR-defined central obesity (adjusted OR = 0.972; 95% CI: 0.947-0.997; p = 0.031), whereas associations with WC- and WHtR-defined central obesity were not significant. CONCLUSION: PDI scores were not consistently associated with measures of general or central adiposity. Although higher scores were associated with modestly lower odds of WHR-defined central obesity, this isolated finding was not supported by the continuous adiposity outcomes and should be considered exploratory. Prospective studies are needed to determine whether this association is reproducible. CI - Copyright (c) 2026 Eman M. Alissa et al. BioMed Research International published by John Wiley & Sons Ltd. FAU - Alissa, Eman M AU - Alissa EM AUID- ORCID: 0000-0001-8905-4870 AD - Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, kau.edu.sa. FAU - Algarni, Samiah A AU - Algarni SA AUID- ORCID: 0009-0005-1204-8639 AD - Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, kau.edu.sa. FAU - Khaffji, Azza J AU - Khaffji AJ AD - Obstetrics and Gynecology, King Abdulaziz Hospital and Oncology Center, Jeddah, Saudi Arabia. FAU - Al Mansouri, Nisma M AU - Al Mansouri NM AUID- ORCID: 0000-0002-4346-1291 AD - Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia, kau.edu.sa. LA - eng GR - 30-37/King Abdulaziz City for Science and Technology/ PT - Journal Article PL - United States TA - Biomed Res Int JT - BioMed research international JID - 101600173 SB - IM MH - Humans MH - Female MH - Saudi Arabia/epidemiology MH - Adult MH - *Obesity/epidemiology/physiopathology MH - Body Mass Index MH - Waist-Hip Ratio MH - Adolescent MH - *Diet, Vegetarian MH - Cross-Sectional Studies MH - Waist Circumference/physiology MH - Young Adult MH - *Feeding Behavior MH - Adiposity PMC - PMC13621456 OTO - NOTNLM OT - BMI OT - FFQ OT - diet pattern OT - vegetarian OT - waist circumference OT - waist-to-hip ratio COIS- The authors declare no conflicts of interest. EDAT- 2026/09/29 12:28 MHDA- 2026/09/29 12:29 PMCR- 2026/09/29 CRDT- 2026/09/29 08:02 PHST- 2026/09/16 00:00 [revised] PHST- 2026/06/02 00:00 [received] PHST- 2026/09/21 00:00 [accepted] PHST- 2026/09/29 12:29 [medline] PHST- 2026/09/29 12:28 [pubmed] PHST- 2026/09/29 08:02 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - BMRI4023284 [pii] AID - 10.1155/bmri/4023284 [doi] PST - ppublish SO - Biomed Res Int. 2026;2026(1):e4023284. doi: 10.1155/bmri/4023284. PMID- 42807469 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260929 LR - 20260930 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Therapeutic response to exclusive enteral nutrition correlates with suppressed IL-17 signaling activity and diminished IL-1beta secretion in pediatric Crohn's disease. PG - 1901066 LID - 10.3389/fnut.2026.1901066 [doi] LID - 1901066 AB - BACKGROUND: To identify molecular correlates associated with therapeutic outcomes of exclusive enteral nutrition (EEN) in pediatric Crohn's disease (PCD). METHODS: This prospective observational cohort study recruited 27 treatment-naive pediatric patients with endoscopically active PCD. Intestinal mucosal tissues were collected via endoscopy at baseline and after EEN treatment. RNA sequencing, principal component analysis (PCA), protein-protein interaction (PPI) analysis, and quantitative real-time polymerase chain reaction (qRT-PCR) were performed to identify and validate differentially expressed genes (DEGs). Patients were classified into mucosal healing [MH, Simple Endoscopic Score for Crohn's Disease (SES-CD) < 3, n = 13] and non-mucosal healing (NMH, SES-CD >/= 3 with ulcers, n = 14) groups according to post-treatment SES-CD. RESULTS: PCA revealed partial transcriptomic segregation between the MH and NMH groups after EEN. Bioinformatic enrichment analysis identified the IL-17 signaling pathway as the most significantly enriched pathway, encompassing nine core DEGs. Integrated qRT-PCR validation and PPI network analysis pinpointed IL-1beta as the key target gene. Correlation analysis demonstrated that intestinal mucosal IL-1beta expression was moderately and positively correlated with SES-CD scores (P = 0.001, r = 0.42, 95% CI: 0.17-0.63), Lewis scores (P < 0.001, r = 0.65, 95% CI: 0.41-0.79), and weighted Pediatric Crohn's Disease Activity Index (wPCDAI) values (P < 0.001, r = 0.51, 95% CI: 0.26-0.69). Moreover, compared with the NMH group, the MH group exhibited lower mucosal expression levels of IL-17A [MH: 0.50 (1.42) vs. NMH: 2.58 (2.05), P = 0.03], IL-17RA (MH: 0.95 +/- 0.37 vs. NMH: 1.34 +/- 0.53, P = 0.04), and IL-17RB [MH: 1.18 (0.54) vs. NMH: 1.64 (1.32), P < 0.01] after EEN treatment. CONCLUSIONS: EEN attenuates intestinal inflammation in PCD, and this therapeutic response may associate with suppressed IL-17 signaling activity and reduced IL-1beta secretion. CI - Copyright (c) 2026 Tang, Wang, Tang, Zheng, Shi, Meng and Huang. FAU - Tang, Wenjuan AU - Tang W AD - Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China. FAU - Wang, Yuhuan AU - Wang Y AD - Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China. FAU - Tang, Zifei AU - Tang Z AD - Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China. FAU - Zheng, Cuifang AU - Zheng C AD - Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China. FAU - Shi, Jieru AU - Shi J AD - Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China. FAU - Meng, Yingying AU - Meng Y AD - Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China. FAU - Huang, Ying AU - Huang Y AD - Department of Gastroenterology, Pediatric Inflammatory Bowel Disease Research Center, National Children's Medical Center, Children's Hospital of Fudan University, Shanghai, China. LA - eng PT - Journal Article DEP - 20260914 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13618058 OTO - NOTNLM OT - Crohn's disease OT - EEN OT - IL-17 OT - IL-1beta OT - pediatric COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/29 12:28 MHDA- 2026/09/29 12:29 PMCR- 2026/09/14 CRDT- 2026/09/29 06:33 PHST- 2026/06/05 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/20 00:00 [accepted] PHST- 2026/09/29 12:29 [medline] PHST- 2026/09/29 12:28 [pubmed] PHST- 2026/09/29 06:33 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - 10.3389/fnut.2026.1901066 [doi] PST - epublish SO - Front Nutr. 2026 Sep 14;13:1901066. doi: 10.3389/fnut.2026.1901066. eCollection 2026. PMID- 42807456 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260929 LR - 20260930 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Integrated multi-omics analysis to explore correlations among cord blood IGF-1 levels, metabolomic profiles, and meconium gut microbiota in small-for-gestational-age neonates. PG - 1942176 LID - 10.3389/fped.2026.1942176 [doi] LID - 1942176 AB - BACKGROUND: Small for gestational age (SGA) infants carry high risks of neonatal complications and lifelong metabolic disorders. This study explored correlations among cord blood IGF-1, cord blood metabolome, and meconium microbiota in SGA neonates to clarify the underlying pathophysiology. METHODS: We consecutively recruited 113 term newborns (53 SGA, 60 AGA) delivered at Hainan Women and Children's Medical Centre from June 2024 to March 2025. Cord blood IGF-1 was tested via chemiluminescence. UHPLC-MS/MS untargeted metabolomics and 16S rRNA high-throughput sequencing were applied to characterize cord blood metabolites and meconium microbiota. Intergroup differences and partial Spearman correlations across IGF-1, metabolites, microbes and birth indices were analyzed, adjusting for gestational age, infant sex, and maternal delivery mode,where applicable. RESULTS: (1) SGA infants had markedly lower cord blood IGF-1 (P < 0.001), which positively correlated with birth weight and length. (partial Spearman r = 0.634 and 0.494, respectively, P < 0.001, after adjusting for gestational age, sex, and maternal BMI). (2) Two groups presented distinct metabolic profiles. SGA infants showed depleted glycerophospholipids, elevated chlorobenzene pollutants, and altered pathways involving bile secretion, choline and steroid metabolism. (3) No alpha diversity difference existed, yet beta diversity confirmed divergent microbial structures (R(2) = 0.0284, P = 0.046). SGA overrepresented Clostridium and Klebsiella, with reduced facultative pioneer bacteria. (4) SGA-enriched anaerobes negatively correlated with birth size and IGF-1, while chlorobenzene levels were positively associated with these pathogenic genera. CONCLUSIONS: SGA neonates feature suppressed IGF-1, intrauterine metabolic disorders and disordered initial gut colonization. Disturbed prenatal metabolism and pollutant exposure may jointly drive aberrant early microbiota development in growth-restricted newborns. The cross-sectional design precludes causal inference, and the chlorobenzene finding warrants independent validation. CI - (c) 2026 Li, Wang, Luo, Xie, Duan, Wang and Huang. FAU - Li, Yuanlong AU - Li Y AD - Department of Paediatrics, Hainan Women and Children's Medical Centre, Haikou, Hainan, China. FAU - Wang, Haizhen AU - Wang H AD - Department of Paediatrics, Hainan Women and Children's Medical Centre, Haikou, Hainan, China. FAU - Luo, Liangying AU - Luo L AD - Department of Paediatrics, Hainan Women and Children's Medical Centre, Haikou, Hainan, China. FAU - Xie, Junwei AU - Xie J AD - Department of Paediatrics, Hainan Women and Children's Medical Centre, Haikou, Hainan, China. FAU - Duan, Yumei AU - Duan Y AD - Department of Paediatrics, Hainan Women and Children's Medical Centre, Haikou, Hainan, China. FAU - Wang, Junqiong AU - Wang J AD - Department of Paediatrics, Hainan Women and Children's Medical Centre, Haikou, Hainan, China. FAU - Huang, Yan AU - Huang Y AD - Department of Paediatrics, Hainan Women and Children's Medical Centre, Haikou, Hainan, China. LA - eng PT - Journal Article DEP - 20260914 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13617061 OTO - NOTNLM OT - 16S rRNA microbiota sequencing OT - cord blood metabolome OT - gut microbiota OT - insulin-like growth factor-1 OT - small for gestational age COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/29 12:28 MHDA- 2026/09/29 12:29 PMCR- 2026/09/14 CRDT- 2026/09/29 06:33 PHST- 2026/07/19 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/30 00:00 [accepted] PHST- 2026/09/29 12:29 [medline] PHST- 2026/09/29 12:28 [pubmed] PHST- 2026/09/29 06:33 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - 10.3389/fped.2026.1942176 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 14;14:1942176. doi: 10.3389/fped.2026.1942176. eCollection 2026. PMID- 42804465 OWN - NLM STAT- Publisher LR - 20260930 IS - 1469-445X (Electronic) IS - 0958-0670 (Print) IS - 0958-0670 (Linking) DP - 2026 Sep 28 TI - Association between dietary fatty acids and all-cause mortality in patients with cirrhosis: A cohort study. LID - 10.1113/EP093526 [doi] AB - Liver cirrhosis imposes a substantial global burden, with complications driving high mortality. Diet is pivotal in managing liver disease progression and cirrhosis-related death. This study investigated associations between total fat intake, specific dietary fatty acid subclasses and all-cause mortality in cirrhotic patients. In this prospective cohort study, 121 ambulatory patients with recently diagnosed cirrhosis (/=4 days/week) were significant associated with a lower probability of VD insufficiency. The global predictive scorecard achieved an optimism-corrected area under the receiver operating characteristic curve (optimism-corrected AUC) of 0.714. Crucially, the subgroup model restricted to overweight individuals (BMI >/= 25 kg/m(2)) demonstrated acceptable exploratory discrimination (optimism-corrected AUC = 0.768, sensitivity 69.2%, specificity 89.7%), serving as a preliminary proof-of-concept assessment for risk stratification. CONCLUSION: By integrating body composition dynamics and cultural habits, this cost-effective model provides a preliminary, exploratory non-invasive screening structure for Paraguayan youth that warrants further multi-center prospective validation before clinical implementation. CI - Copyright (c) 2026 Gonzalez, Mino, Espinoza, Cano, Recalde, Miguel and Ishikawa. FAU - Gonzalez, Anabel AU - Gonzalez A AD - Department of Biochemistry, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. FAU - Mino, Camila AU - Mino C AD - Department of Biochemistry, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. AD - Department of Medicine, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. FAU - Espinoza, Elena AU - Espinoza E AD - Department of Biochemistry, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. FAU - Cano, Marlene AU - Cano M AD - Department of Medicine, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. FAU - Recalde, Milciades AU - Recalde M AD - Department of Biochemistry, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. FAU - Miguel, Carlos AU - Miguel C AD - Department of Biochemistry, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. AD - Department of Medicine, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. FAU - Ishikawa, Dai AU - Ishikawa D AD - Department of Biochemistry, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. AD - Department of Medicine, Faculty of Health Science, Universidad Santa Clara de Asis (USCA), Caaguazu, Paraguay. AD - Japan International Cooperation Agency (JICA), Asuncion, Paraguay. LA - eng PT - Journal Article DEP - 20260911 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13612359 OTO - NOTNLM OT - body composition OT - logistic regression OT - mate consumption OT - predictive model OT - traditional habit OT - vitamin D insufficiency COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/27 02:27 MHDA- 2026/09/27 02:28 PMCR- 2026/09/11 CRDT- 2026/09/26 05:12 PHST- 2026/07/30 00:00 [received] PHST- 2026/08/16 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/27 02:28 [medline] PHST- 2026/09/27 02:27 [pubmed] PHST- 2026/09/26 05:12 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 10.3389/fnut.2026.1953400 [doi] PST - epublish SO - Front Nutr. 2026 Sep 11;13:1953400. doi: 10.3389/fnut.2026.1953400. eCollection 2026. PMID- 42798427 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260927 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Physical literacy and adolescent mental well-being: A chain mediation of basic psychological needs satisfaction and emotion regulation. PG - 1950111 LID - 10.3389/fpsyg.2026.1950111 [doi] LID - 1950111 AB - BACKGROUND: Adolescent mental wellbeing is a pressing global concern. Physical literacy (PL) - the motivation, confidence, physical competence, knowledge, and understanding to value physical activity for life - has emerged as a potentially protective factor for mental wellbeing. However, the mechanisms linking PL to mental wellbeing remain poorly understood. Drawing on Self-Determination Theory and emotion regulation theory, this study examined whether basic psychological needs satisfaction (BPNS) and emotion regulation serve as sequential mediators in the PL-mental wellbeing relationship among adolescents. METHODS: A cross-sectional survey was conducted in November 2024 with 687 Chinese middle school students from Hubei Province (48.3% female; aged 12-16 years), recruited using stratified cluster sampling from three public schools. Participants completed validated Chinese measures of physical literacy (PPLI), basic psychological needs (BPNSFS), emotion regulation (ERQ), and mental wellbeing (WEMWBS). Covariance-based structural equation modeling (robust maximum likelihood) with bias-corrected bootstrapping (5,000 resamples) tested the chain mediation model. RESULTS: The final analytical sample comprised 687 adolescents (48.3% female), who reported moderate levels of PL (M = 3.42, SD = 0.68), BPNS (M = 3.56, SD = 0.62), cognitive reappraisal (M = 4.52, SD = 1.08), and mental wellbeing (M = 3.51, SD = 0.71). PL was positively associated with mental wellbeing (beta = 0.38, p < 0.001), the standardized total effect estimated in the structural equation model. The direct effect remained significant (beta = 0.14, p = 0.006). The chain mediation pathway - PL --> BPNS --> emotion regulation --> mental wellbeing - was significant (indirect effect = 0.12, 95% CI [0.08, 0.17]), accounting for 31.6% of the total effect. Individual mediation paths through BPNS (indirect effect = 0.05, 95% CI [0.01, 0.09]) and emotion regulation (indirect effect = 0.07, 95% CI [0.04, 0.11]) were also significant. The model explained 42% of the variance in mental wellbeing. CONCLUSION: These findings suggest that PL is associated with adolescent mental wellbeing through a sequential pathway involving BPNS and emotion regulation. The results highlight the potential value of PL development and need-supportive environments in educational settings. Future longitudinal research is needed to examine temporal dynamics. CI - Copyright (c) 2026 Zhang. FAU - Zhang, Bing AU - Zhang B AD - Institute of Physical Education, Huanggang Normal University, Huanggang, Hubei, China. LA - eng PT - Journal Article DEP - 20260911 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13612352 OTO - NOTNLM OT - Self-Determination Theory OT - adolescents OT - basic psychological needs satisfaction OT - chain mediation OT - emotion regulation OT - mental wellbeing OT - physical literacy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/11 CRDT- 2026/09/26 04:58 PHST- 2026/07/27 00:00 [received] PHST- 2026/08/31 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 04:58 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1950111 [doi] PST - epublish SO - Front Psychol. 2026 Sep 11;17:1950111. doi: 10.3389/fpsyg.2026.1950111. eCollection 2026. PMID- 42798108 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260930 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 39 DP - 2026 Sep 25 TI - Research hotspots and emerging trends of pain neuroscience education in chronic pain management: A bibliometric visualization study. PG - e50742 LID - 10.1097/MD.0000000000050742 [doi] LID - e50742 AB - OBJECTIVE: Chronic pain is a major global public health concern. Pain neuroscience education (PNE), a cognitive intervention grounded in the biopsychosocial model, has been increasingly applied to chronic pain management. However, its knowledge structure and research evolution have not been systematically delineated. This bibliometric study aimed to map the research landscape, identify hot topics and emerging trends, and provide evidence for clinical translation and research planning. METHODS: Publications on PNE in chronic pain were retrieved from the Web of Science Core Collection (2015-2026). A total of 409 articles were analyzed using Microsoft Excel, CiteSpace, VOSviewer, Bibliometrix, and SCImago Graphica to examine publication outputs, collaboration networks, keyword co-occurrence, clustering, burst detection, and citation patterns. RESULTS: Annual publications increased rapidly from 2018 to 2024, peaking in 2024. The United States, Spain, and Belgium were the most productive countries, with strong collaboration between North America and Europe, while Asian and low-and middle-income countries remained peripheral. Jo Nijs team was a central research force. Keyword analysis revealed 3 hotspots: predominant focus on chronic musculoskeletal pain; a shift from single PNE to multimodal regimens combining exercise and cognitive behavioral therapy; methodological validation of assessment tools serving as a critical hub linking research branches. Burst analysis indicated a transition from empirical accumulation to evidence synthesis with personalized interventions for older adults and adolescents as future frontiers. CONCLUSION: PNE research is advancing rapidly, shifting from efficacy validation toward implementation science and precision interventions. Current research shows a geographic imbalance; future efforts should enhance cross-regional knowledge translation. This study provides a clear knowledge map for researchers and evidence-based directions for optimizing pain management systems. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Chen, Yixin AU - Chen Y AD - School of Nursing, Inner Mongolia Medical University, No. 5 Xinhua Street, Hohhot, Inner Mongolia Autonomous Region, China. FAU - Yu, Huamei AU - Yu H AD - Department of Nursing, The Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Huimin District, Hohhot, Inner Mongolia Autonomous Region, China. FAU - Dang, Lixian AU - Dang L AD - School of Nursing, Inner Mongolia Medical University, No. 5 Xinhua Street, Hohhot, Inner Mongolia Autonomous Region, China. FAU - Li, Lingling AU - Li L AD - School of Nursing, Inner Mongolia Medical University, No. 5 Xinhua Street, Hohhot, Inner Mongolia Autonomous Region, China. FAU - Li, Chenyang AU - Li C AD - Department of Nursing, The Affiliated Hospital of Inner Mongolia Medical University, No. 1 Tongdao North Street, Huimin District, Hohhot, Inner Mongolia Autonomous Region, China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - *Chronic Pain/therapy MH - Humans MH - *Neurosciences/education MH - *Pain Management/methods MH - *Bibliometrics PMC - PMC13619212 OTO - NOTNLM OT - CiteSpace OT - chronic pain OT - pain neuroscience education OT - research hotspots OT - visualization analysis COIS- The authors have no funding and conflicts of interest to declare. EDAT- 2026/09/26 05:35 MHDA- 2026/09/27 02:27 PMCR- 2026/09/25 CRDT- 2026/09/26 01:18 PHST- 2026/06/10 00:00 [received] PHST- 2026/09/01 00:00 [accepted] PHST- 2026/09/27 02:27 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:18 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - 00005792-202609250-00078 [pii] AID - MD-D-26-08842 [pii] AID - 10.1097/MD.0000000000050742 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Sep 25;105(39):e50742. doi: 10.1097/MD.0000000000050742. PMID- 42797089 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 21 TI - Domain-Dependent Performance of Human Experts and AI Systems in Pediatric Menu Evaluation. LID - 10.3390/nu18183106 [doi] LID - 3106 AB - BACKGROUND/OBJECTIVES: Artificial intelligence (AI) tools are increasingly used for dietary assessment, but their reliability in pediatric nutrition remains uncertain. This study compared AI systems and human evaluators in pediatric menu assessment against expert-defined reference ratings. METHODS: This observational cross-sectional study used anonymized dietary and clinical information from three healthy pediatric cases. A multidisciplinary panel of pediatric nutrition specialists established standard evaluations. Assessments were completed by 84 AI evaluations, 116 nutrition specialists, 56 pediatric-focused physicians, and 88 physicians from other specialties. Outcomes included absolute error in total energy estimation, deviations in portion and qualitative ratings, standardized scores, and binary adequacy accuracy. Groups were compared using ANOVA or Kruskal-Wallis tests with post hoc analyses. RESULTS: A total of 344 assessments were included. Energy-estimation error differed between groups (Kruskal-Wallis = 12.85, p = 0.0016), but this analysis was based on a limited and highly unbalanced subset of 77 assessments. AI had the largest mean absolute error (260.3 +/- 194.3 kcal), followed by nutrition specialists (148.4 +/- 81.5 kcal); physicians with other specialties had the lowest error (60.4 +/- 53.3 kcal); these subgroup comparisons should be interpreted cautiously because of the small and unequal numbers of available energy estimates. AI showed greater portion-rating deviation (0.488; 95% CI: 0.38-0.60) than nutrition specialists (0.310; 95% CI: 0.20-0.42; p = 0.0019, q = 0.0059) and pediatric-focused physicians (0.286; 95% CI: 0.16-0.41; p = 0.0181, q = 0.019). Conversely, AI showed the lowest deviations for variety (0.37 +/- 0.49) and processing (0.33 +/- 0.47), compared with 1.15-1.36 and 1.22-1.57, respectively, among human groups (both p = 0.0001). CONCLUSIONS: AI may support structured pediatric menu screening for descriptive qualitative features; however, lower precision for energy and portion assessment supports, under these specific conditions, its use as an adjunct, for qualified nutrition professionals. FAU - Martin-Hadmas, Roxana Maria AU - Martin-Hadmas RM AUID- ORCID: 0000-0003-1499-5398 AD - Department of Community Nutrition and Food Safety, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu 38, 540139 Targu Mures, Romania. FAU - Sovea, Rebeca AU - Sovea R AD - Department of Community Nutrition and Food Safety, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu 38, 540139 Targu Mures, Romania. FAU - Pol, Diana AU - Pol D AD - Department of Community Nutrition and Food Safety, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu 38, 540139 Targu Mures, Romania. FAU - Gavra, George Mihaita AU - Gavra GM AUID- ORCID: 0009-0007-9594-1231 AD - Center for Advanced Medical and Pharmaceutical Research, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania. FAU - Tarcea, Monica AU - Tarcea M AUID- ORCID: 0000-0001-7299-118X AD - Department of Community Nutrition and Food Safety, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology of Targu Mures, Gheorghe Marinescu 38, 540139 Targu Mures, Romania. FAU - Neghirla, Adriana AU - Neghirla A AD - Mures School Medicine Association, 540233 Targu Mures, Romania. FAU - Martin, Stefan Adrian AU - Martin SA AD - Center for Advanced Medical and Pharmaceutical Research, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania. LA - eng PT - Journal Article PT - Observational Study DEP - 20260921 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Artificial Intelligence MH - *Nutrition Assessment MH - Child MH - Female MH - Reproducibility of Results MH - Energy Intake MH - Male MH - *Menu Planning MH - Pediatrics MH - Nutritionists PMC - PMC13610824 OTO - NOTNLM OT - artificial intelligence OT - clinical decision support OT - dietary assessment OT - energy estimation OT - large language models OT - menu evaluation OT - nutrition professionals OT - pediatric nutrition COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/21 CRDT- 2026/09/26 01:15 PHST- 2026/08/17 00:00 [received] PHST- 2026/09/14 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - nu18183106 [pii] AID - nutrients-18-03106 [pii] AID - 10.3390/nu18183106 [doi] PST - epublish SO - Nutrients. 2026 Sep 21;18(18):3106. doi: 10.3390/nu18183106. PMID- 42797068 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 20 TI - Iodine Nutrition, Non-Genetic Factors, and Two Candidate Polymorphisms Associated with Thyroid Function Abnormalities Among Children Aged 8-10 Years in Iodine-Adequate Areas of Tianjin, China. LID - 10.3390/nu18183085 [doi] LID - 3085 AB - Background/Objectives: As dietary and environmental exposures change, interacting with genetic susceptibility, the prevalence of thyroid function abnormality and subclinical thyroid dysfunction in children is rising, yet systematic research in this population remains scarce. Methods: From 13 districts of Tianjin, China, all characterized by adequate iodine levels, 997 children between the ages of 8-10 years were recruited using a school-based sampling approach. Peripheral venous blood samples were drawn for genotyping analysis of two single nucleotide polymorphisms (SNPs): thyroid stimulating hormone receptor (TSHR) rs2268458 and NK2 homeobox 1 (NKX2-1) rs2076735 using the Sequenom MassARRAY platform. In addition, data on 31 non-genetic factors, including urinary iodine concentration (UIC), were collected. Restricted cubic spline (RCS) models were used to examine the non-linear associations between UIC and thyroid abnormalities. Multivariable Poisson regression was applied to identify factors associated with thyroid outcomes. Results: The overall prevalence of thyroid function abnormality in the study population was 17.35%, with detection rates of 3.51% for subclinical hyperthyroidism and 2.21% for subclinical hypothyroidism. After adjusting for age, sex, body mass index z-score (BMI-z-score), district of residence, and recruitment year, RCS models revealed significant U-shaped non-linear associations between UIC and both free triiodothyronine (FT(3)) abnormality (P(overall) = 0.003, P(nonlinear) < 0.001) and overall thyroid function abnormality (P(overall) = 0.042, P(nonlinear) = 0.029). In multivariable analysis, after Bonferroni correction within prespecified hypothesis families, family history of thyroid disease in first-degree relatives remained significantly associated with subclinical hyperthyroidism (adjusted p = 0.015), and UIC < 100 mug/L remained significantly associated with overall thyroid function abnormality (adjusted p = 0.036). In addition, district of residence was associated with subclinical hypothyroidism after correction (adjusted p = 0.009). Stratified analyses revealed potential subgroup-specific effects. Children with the NKX2-1 rs2076735 TT + TC genotype and UIC < 100 mug/L had a higher prevalence of thyroid function abnormality compared with the reference group (UIC 100-299 mug/L) (p = 0.031, PR = 3.093, 95% CI: 1.108, 8.636). Frequent consumption of kelp or laver soup was associated with a higher prevalence of subclinical hyperthyroidism among children with the NKX2-1 rs2076735 CC genotype or the TSHR rs2268458 TT genotype (p = 0.049, PR = 3.636, 95% CI: 1.006, 13.140; p = 0.023, PR = 4.814, 95% CI: 1.245, 18.610, respectively). Among children with the NKX2-1 rs2076735 CC genotype, those with a family history of thyroid disease had a higher prevalence of subclinical hyperthyroidism (p = 0.029, PR = 4.114, 95% CI: 1.152, 14.688). After Benjamini-Hochberg false discovery rate correction, none of the subgroup-specific associations remained statistically significant (adjusted p-values: 0.058-0.065). Conclusions: The prevalence of thyroid function abnormality and subclinical thyroid dysfunction was relatively high among school-aged children in this study population from Tianjin, China. After adjustment for covariates and correction for multiple comparisons, family history of thyroid disease, UIC < 100 mug/L, and district of residence remained significantly associated with subclinical hyperthyroidism, overall thyroid function abnormality, and subclinical hypothyroidism, respectively. A U-shaped association was observed between UIC and thyroid health, highlighting the importance of maintaining adequate iodine nutrition. However, stratified analyses suggested potential subgroup-specific associations that require validation in larger, independent cohorts. FAU - Duan, Yani AU - Duan Y AD - Institute of Environment and Public Health, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, China. FAU - Wang, Yang AU - Wang Y AD - Institute of Environment and Public Health, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, China. FAU - Li, Fang AU - Li F AD - Institute of Environment and Public Health, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, China. FAU - Li, Wenfeng AU - Li W AD - Institute of Environment and Public Health, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, China. FAU - Zhang, Dandan AU - Zhang D AD - Institute of Environment and Public Health, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, China. FAU - Cui, Yushan AU - Cui Y AD - Institute of Environment and Public Health, Tianjin Centers for Disease Control and Prevention, 6 Huayue Road, Hedong District, Tianjin 300011, China. LA - eng GR - TJWJ2024QN091/Tianjin Health Research Project/ GR - 82173641/National Natural Science Foundation of China/ GR - TJYXZDXK-3-020B/Tianjin Key Medical Discipline Construction/ PT - Journal Article DEP - 20260920 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 9679TC07X4 (Iodine) RN - 0 (Receptors, Thyrotropin) RN - 0 (Thyroid Nuclear Factor 1) RN - 0 (TSHR protein, human) SB - IM MH - Humans MH - *Iodine/urine/administration & dosage/deficiency MH - China/epidemiology MH - Child MH - Female MH - Male MH - *Polymorphism, Single Nucleotide MH - Hyperthyroidism/genetics/epidemiology MH - *Thyroid Gland/physiopathology MH - *Receptors, Thyrotropin/genetics MH - Prevalence MH - Genetic Predisposition to Disease MH - *Hypothyroidism/genetics/epidemiology MH - *Nutritional Status MH - *Thyroid Nuclear Factor 1/genetics MH - *Thyroid Diseases/genetics/epidemiology MH - Thyroid Function Tests PMC - PMC13610479 OTO - NOTNLM OT - Iodine status OT - NKX2-1 OT - TSHR OT - children OT - subclinical thyroid dysfunction OT - thyroid function abnormality COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/20 CRDT- 2026/09/26 01:15 PHST- 2026/08/12 00:00 [received] PHST- 2026/09/11 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/20 00:00 [pmc-release] AID - nu18183085 [pii] AID - nutrients-18-03085 [pii] AID - 10.3390/nu18183085 [doi] PST - epublish SO - Nutrients. 2026 Sep 20;18(18):3085. doi: 10.3390/nu18183085. PMID- 42797056 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 20 TI - Pro-Inflammatory Dietary Profiles Are Associated with Psychosocial Functioning in Spanish Adolescents: Findings from the EHDLA Study. LID - 10.3390/nu18183073 [doi] LID - 3073 AB - Background: Dietary factors may influence psychosocial outcomes through inflammatory pathways, but evidence in adolescents remains limited. The aim was to examine whether dietary inflammatory potential is associated with psychosocial functioning among Spanish adolescents. Methods: This cross-sectional study is based on a subsample from the Eating Healthy and Daily Life Activities (EHDLA) project, conducted in the Region of Murcia (Spain). Dietary inflammatory potential was assessed using a dietary inflammatory index (DII)-informed Food Frequency Questionnaire (FFQ)-derived inflammatory score based on a validated 45-item food frequency questionnaire. Behavioral functioning was evaluated using the Strengths and Difficulties Questionnaire (SDQ). Associations between DII-informed FFQ-derived inflammatory scores and SDQ outcomes were examined using robust linear regression models adjusted for sociodemographic, lifestyle, and anthropometric factors. Results: The analysis included 674 adolescents (57.1% girls; age: 14.0 [13.0-15.0] years). Higher DII-informed FFQ-derived inflammatory score (more pro-inflammatory diet) was associated with greater total behavioral difficulties (unstandardized beta coefficient [B] = 0.058; 95% confidence interval [CI]: 0.005-0.111; standardized beta = 0.099), conduct problems (B = 0.025; 95% CI: 0.011-0.039; beta = 0.148), hyperactivity/inattention (B = 0.032; 95% CI: 0.013-0.052; beta = 0.154), and externalizing problems (B = 0.056; 95% CI: 0.028-0.084; beta = 0.181), and with lower prosocial behavior (B = -0.029; 95% CI: -0.045 to -0.014; beta = -0.149). Multiple imputation sensitivity analyses yielded estimates in a similar direction, although the associations did not reach statistical significance. No significant associations were observed for emotional symptoms, peer relationship problems, or internalizing difficulties. Conclusions: Higher dietary inflammatory potential was associated with a less favorable psychosocial functioning profile among adolescents, particularly in externalizing domains. Longitudinal studies and anti-inflammatory dietary interventions are needed to determine whether the observed associations translate into meaningful changes in psychosocial functioning. FAU - Marrero-Fernandez, Paula AU - Marrero-Fernandez P AUID- ORCID: 0009-0009-0031-0408 AD - Department of Chemical Engineering and Pharmaceutical Technology, University of La Laguna, Avda. Astrofisico Francisco Sanchez s/n, 38001 Santa Cruz de Tenerife, Spain. FAU - Munoz-Pardeza, Jacinto AU - Munoz-Pardeza J AUID- ORCID: 0000-0002-0210-2866 AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain. FAU - Mino, Camila AU - Mino C AUID- ORCID: 0000-0002-9444-8564 AD - European Institute of Higher Studies (IEES), 4820-509 Fafe, Portugal. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - School of Medicine, Universidad Espiritu Santo, Samborondon 092301, Ecuador. AD - Faculty of Health Sciences, Universidad Autonoma de Chile, Temuco 4810101, Chile. FAU - Lopez-Moreno, Miguel AU - Lopez-Moreno M AUID- ORCID: 0000-0003-0553-6210 AD - Diet, Planetary Health and Performance, Faculty of Health Sciences, Universidad Francisco de Vitoria, 28223 Madrid, Spain. AD - Institute of Health and Sport Sciences, Faculty of Health Science, Universidad Francisco de Vitoria, 28223 Madrid, Spain. LA - eng PT - Journal Article DEP - 20260920 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Female MH - Spain/epidemiology MH - Cross-Sectional Studies MH - Male MH - *Inflammation/psychology/etiology MH - *Diet/adverse effects MH - *Psychosocial Functioning MH - *Adolescent Behavior/psychology MH - Surveys and Questionnaires MH - Feeding Behavior PMC - PMC13610942 OTO - NOTNLM OT - adolescents OT - behavioral problems OT - diet-related inflammation OT - dietary inflammatory index OT - psychosocial functioning OT - strengths and difficulties questionnaire COIS- ML-M reports having previously received remuneration from Danone and Foods For Tomorrow for advisory board participation and consulting activities. These activities were unrelated to the submitted work and are not ongoing. At present, he has no active financial relationships with these entities. All other authors reported no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/20 CRDT- 2026/09/26 01:15 PHST- 2026/08/06 00:00 [received] PHST- 2026/09/08 00:00 [revised] PHST- 2026/09/10 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/20 00:00 [pmc-release] AID - nu18183073 [pii] AID - nutrients-18-03073 [pii] AID - 10.3390/nu18183073 [doi] PST - epublish SO - Nutrients. 2026 Sep 20;18(18):3073. doi: 10.3390/nu18183073. PMID- 42797034 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260930 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 18 TI - Dietary Behaviours Mediate Intervention Effects on Body Composition Outcomes in Children: Evidence from a Cluster-Randomised Controlled Trial. LID - 10.3390/nu18183051 [doi] LID - 3051 AB - BACKGROUND/OBJECTIVES: Few paediatric obesity trials have examined behavioural mediators of intervention effects on detailed body composition outcomes beyond body mass index (BMI). Given the complexity of multiple correlated body composition indicators, this study aimed to employ principal component analysis (PCA) to derive a composite adiposity factor and to apply mediation analysis to identify whether changes in dietary behaviours and physical activity mediated the effects of the DECIDE-Children intervention on body composition. METHODS: This study included 1180 children from a 9-month cluster-randomised controlled trial that delivered a multifaceted, digitally assisted intervention targeting children (health education, physical activity reinforcement, and app-based BMI monitoring/feedback) and their environments (school food policies and family engagement). Outcomes were changes in body composition (whole-body and trunk fat mass, fat-free mass, and muscle mass indices measured by bioelectrical impedance analysis). Potential mediators included changes in dietary behaviour, screen time, and moderate-to-vigorous physical activity (MVPA), assessed via validated questionnaires. PCA was used to reduce the dimensionality of body composition variables and to derive a composite adiposity factor (PCA_1), with higher values indicating greater adiposity and lower muscle mass. Mediation was tested using linear mixed-effects models adjusted for age, sex, and region. RESULTS: The intervention significantly reduced adiposity indicators (e.g., whole-body and trunk fat mass percentage decreased by 1.003%, and PCA_1 decreased by 0.942 SD) and concurrently increased fat-free mass percentage and muscle mass percentage at both whole-body and trunk levels. Dietary behaviour significantly mediated the intervention effects on all body composition outcomes (e.g., mediating 16.1% of the effect on PCA_1), whereas physical activity (both screen time and MVPA) showed no mediation. Sensitivity analyses supported the primary findings. CONCLUSIONS: The DECIDE-Children intervention improved body composition by reducing adiposity and increasing fat-free and muscle mass percentage, effects primarily mediated by dietary behaviour. These findings highlight dietary behaviour as a key component in paediatric obesity intervention. FAU - Zhang, Li AU - Zhang L AUID- ORCID: 0000-0002-0367-0419 AD - Clinical Research Center for Children's Health and Diseases, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan 250014, China. FAU - Wang, Lu AU - Wang L AD - National Health Commission Key Laboratory of Reproductive Health, Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China. FAU - Yin, Chun-Jie AU - Yin CJ AD - National Health Commission Key Laboratory of Reproductive Health, Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China. FAU - Duan, Yu-Qi AU - Duan YQ AD - National Health Commission Key Laboratory of Reproductive Health, Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China. FAU - Ma, Jiaolong AU - Ma J AD - School of Public Health, Shihezi University, Shihezi 832000, China. FAU - Yan, Shi-Yu AU - Yan SY AUID- ORCID: 0009-0003-4067-9652 AD - National Health Commission Key Laboratory of Reproductive Health, Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China. FAU - Chin, Yit Siew AU - Chin YS AUID- ORCID: 0000-0002-7609-1944 AD - Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang 43400, Malaysia. FAU - Li, Yan AU - Li Y AUID- ORCID: 0000-0003-2233-7061 AD - Clinical Research Center for Children's Health and Diseases, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan 250014, China. FAU - Wang, Hai-Jun AU - Wang HJ AUID- ORCID: 0000-0003-0849-2903 AD - School of Public Health, Shihezi University, Shihezi 832000, China. AD - National Health Commission Key Laboratory of Reproductive Health, Department of Maternal and Child Health, School of Public Health, Peking University, Beijing 100191, China. LA - eng GR - Z20243204/Shandong Province Traditional Chinese Medicine Science and Technology Project/ GR - SFYZXET-202501/Shandong Maternal and Child Health Association Child Growth and Development Medical Research Project/ GR - 2016YFC1300204/National Key R&D Program of China/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20260918 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Female MH - Child MH - *Body Composition MH - Exercise MH - *Feeding Behavior MH - Adiposity MH - Body Mass Index MH - *Pediatric Obesity/prevention & control/therapy MH - Principal Component Analysis MH - *Diet MH - *Health Behavior MH - Cluster Analysis PMC - PMC13610272 OTO - NOTNLM OT - body composition OT - children OT - dietary behaviour OT - mediation analysis OT - obesity OT - principal component analysis OT - randomised controlled trial COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/18 CRDT- 2026/09/26 01:15 PHST- 2026/07/24 00:00 [received] PHST- 2026/09/09 00:00 [revised] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - nu18183051 [pii] AID - nutrients-18-03051 [pii] AID - 10.3390/nu18183051 [doi] PST - epublish SO - Nutrients. 2026 Sep 18;18(18):3051. doi: 10.3390/nu18183051. PMID- 42797003 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 16 TI - Dried Blood Spot-Based Monitoring of Dietary Treatment in Children, Adolescents, and Young Adults with Inherited Disorders of Amino Acid Metabolism: A Four-Year Pilot Study. LID - 10.3390/nu18183020 [doi] LID - 3020 AB - Background: Regular biochemical monitoring is essential for the safe and effective dietary treatment of inherited disorders of amino acid metabolism. However, conventional venous blood sampling may limit monitoring frequency and increase the burden on families. This study evaluated the feasibility and clinical usefulness of home-collected dried blood spot (DBS) samples analyzed using tandem mass spectrometry and additional chromatographic methods for dietary monitoring in inherited disorders of amino acid metabolism other than phenylketonuria. Methods: Between 2022 and 2025, children, adolescents, and young adults aged between 4 months and 20.5 years who were followed at a national metabolic center were monitored using DBS samples. The initial cohort included patients with maple syrup urine disease, tyrosinemia type III, homocystinuria, glutaric aciduria type 1, methylmalonic aciduria, isovaleric aciduria, argininosuccinic aciduria, methionine adenosyltransferase I/III deficiency, beta-ketothiolase deficiency, propionic aciduria, gyrate atrophy, and citrullinemia type 1. Disease-specific amino acids and metabolites were assessed to guide individualized dietary recommendations. Results: The number of monitored patients ranged from 24 to 40 per year. Overall annual completion rates of planned DBS measurements ranged from 56.7% to 73.0%, with additional clinically indicated samples collected in selected patients. DBS monitoring detected abnormal metabolite concentrations and supported dietary interventions, particularly in maple syrup urine disease, glutaric aciduria type 1, homocystinuria, tyrosinemia type III, and MAT I/III deficiency. In several other disorders, routine monthly DBS monitoring showed limited additional clinical value. Conclusions: DBS-based monitoring is a feasible approach that may support individualized dietary management in selected inherited disorders of amino acid metabolism, especially in early childhood and during periods of increased metabolic risk. FAU - Kowalik, Agnieszka AU - Kowalik A AUID- ORCID: 0000-0002-7368-3901 AD - Department of Inborn Errors of Metabolism and Pediatrics, Institute of Mother and Child, 01-211 Warsaw, Poland. FAU - Glab-Jablonska, Ewa AU - Glab-Jablonska E AUID- ORCID: 0000-0002-8061-0049 AD - Department of Metabolic Screening and Diagnostics, Institute of Mother and Child, 01-211 Warsaw, Poland. FAU - Taybert, Joanna AU - Taybert J AUID- ORCID: 0000-0002-3352-2126 AD - Department of Inborn Errors of Metabolism and Pediatrics, Institute of Mother and Child, 01-211 Warsaw, Poland. FAU - Nogalska, Marta AU - Nogalska M AD - Department of Inborn Errors of Metabolism and Pediatrics, Institute of Mother and Child, 01-211 Warsaw, Poland. FAU - Sasin-Rokita, Mariola AU - Sasin-Rokita M AUID- ORCID: 0009-0008-3459-7534 AD - Department of Metabolic Screening and Diagnostics, Institute of Mother and Child, 01-211 Warsaw, Poland. FAU - Chelchowska, Magdalena AU - Chelchowska M AUID- ORCID: 0000-0002-6174-6813 AD - Department of Metabolic Screening and Diagnostics, Institute of Mother and Child, 01-211 Warsaw, Poland. FAU - Myszkowska-Ryciak, Joanna AU - Myszkowska-Ryciak J AUID- ORCID: 0000-0001-7167-1993 AD - Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS), 02-776 Warsaw, Poland. FAU - Sykut-Cegielska, Jolanta AU - Sykut-Cegielska J AUID- ORCID: 0000-0003-0762-3721 AD - Department of Inborn Errors of Metabolism and Pediatrics, Institute of Mother and Child, 01-211 Warsaw, Poland. LA - eng PT - Journal Article DEP - 20260916 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Amino Acids) SB - IM MH - Humans MH - Pilot Projects MH - Adolescent MH - *Amino Acid Metabolism, Inborn Errors/diet therapy/blood/diagnosis MH - Female MH - Child MH - Child, Preschool MH - Male MH - Infant MH - *Amino Acids/blood/metabolism MH - *Dried Blood Spot Testing/methods MH - Young Adult MH - Tandem Mass Spectrometry MH - Feasibility Studies PMC - PMC13610832 OTO - NOTNLM OT - amino acid metabolism disorders OT - dietary treatment monitoring OT - dried blood spot OT - inborn errors of metabolism OT - metabolic control OT - tandem mass spectrometry COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/16 CRDT- 2026/09/26 01:15 PHST- 2026/06/25 00:00 [received] PHST- 2026/07/23 00:00 [revised] PHST- 2026/09/14 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/16 00:00 [pmc-release] AID - nu18183020 [pii] AID - nutrients-18-03020 [pii] AID - 10.3390/nu18183020 [doi] PST - epublish SO - Nutrients. 2026 Sep 16;18(18):3020. doi: 10.3390/nu18183020. PMID- 42796999 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 15 TI - Tibetan Butter Tea Consumption and Cognitive Performance Among Tibetan Adolescents at High Altitude. LID - 10.3390/nu18183017 [doi] LID - 3017 AB - Background: Tibetan butter tea sits at a tension between the health concerns raised by its high salt and fat content and the potential cognitive benefits of its tea-derived constituents, yet whether this traditional beverage is associated with cognition in high-altitude Tibetan adolescents has not been directly examined. Methods: We conducted a school-based cross-sectional study of Tibetan students in grades 7-12 in Lhasa, Xizang, China, between June 2024 and June 2025. The analytic sample included 7967 students, with ages ranging from 10.18 to 24.82 years (mean +/- SD: 16.06 +/- 1.80). Butter tea consumption frequency was self-reported. Cognitive performance was assessed with Raven's Standard Progressive Matrices; low cognitive performance was defined as a score below the grade-specific 25th percentile. Logistic regression with cluster-robust standard errors estimated odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for demographic, family, socioeconomic, sleep, physical activity, and lifestyle factors, both overall and in sex-specific models. Results: Among 7967 Tibetan students, 3534 were male, and 4433 were female. Low cognitive performance was most prevalent among students reporting daily (29.56%) or never (26.34%) consumption and less prevalent among those reporting occasional (22.18%) or frequent (20.39%) consumption. Compared with never consumption, occasional consumption (aOR = 0.79; 95% CI, 0.70-0.88; p < 0.001) and frequent consumption (aOR = 0.71; 95% CI, 0.55-0.90; p = 0.004) were associated with lower odds of low cognitive performance. Daily consumption was not statistically significant. In sex-stratified analyses, frequent consumption was associated with lower odds among males (aOR = 0.68; 95% CI, 0.49-0.93; p = 0.018). Among females, both occasional (aOR = 0.76; 95% CI, 0.64-0.90; p = 0.001) and frequent (aOR = 0.74; 95% CI, 0.58-0.93; p = 0.011) consumption were associated with lower odds. Conclusions: Occasional and frequent consumption of Tibetan butter tea was associated with reduced odds of low cognitive performance among Tibetan adolescents at high altitude, with modest sex differences. These findings suggest that Tibetan butter tea should be evaluated as a culturally embedded whole-dietary exposure and may inform culturally sensitive school-based nutrition education and public health guidance in high-altitude Tibetan settings; however, causal inference cannot be established from this cross-sectional study, and longitudinal validation is needed. FAU - Deng, Liping AU - Deng L AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. FAU - Fang, Yuhang AU - Fang Y AD - Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, China. FAU - Pingcuo, Pingcuo AU - Pingcuo P AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. FAU - Cirenyangzong, Cirenyangzong AU - Cirenyangzong C AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. FAU - Zhao, Wenhu AU - Zhao W AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. FAU - Zhao, Junmei AU - Zhao J AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. FAU - Wang, Yanhui AU - Wang Y AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. FAU - Xu, Simin AU - Xu S AUID- ORCID: 0000-0003-4853-7598 AD - Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, China. FAU - Lian, Qiguo AU - Lian Q AUID- ORCID: 0000-0001-8307-0116 AD - Lhasa Center for Disease Control and Prevention, Lhasa 850005, China. AD - Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies, Shanghai 200237, China. LA - eng GR - XZ202301ZY0045G/Science and Technology Projects of Xizang Autonomous Region, China/ GR - XZ2023ZR-ZY25(Z)/Xizang Natural Science Foundation/ PT - Journal Article DEP - 20260915 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Tea) SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - Tibet MH - *Altitude MH - *Cognition MH - Cross-Sectional Studies MH - *Tea MH - Child MH - Young Adult MH - Students PMC - PMC13610373 OTO - NOTNLM OT - Tibetan butter tea OT - Xizang OT - cognitive performance OT - high altitude OT - students COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/27 02:27 PMCR- 2026/09/15 CRDT- 2026/09/26 01:15 PHST- 2026/07/16 00:00 [received] PHST- 2026/09/11 00:00 [revised] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/09/27 02:27 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - nu18183017 [pii] AID - nutrients-18-03017 [pii] AID - 10.3390/nu18183017 [doi] PST - epublish SO - Nutrients. 2026 Sep 15;18(18):3017. doi: 10.3390/nu18183017. PMID- 42796989 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 14 TI - Retinal and Choroidal Vascular Changes Associated with Vitamin D Deficiency. LID - 10.3390/nu18183006 [doi] LID - 3006 AB - Vitamin D is involved in endothelial regulation, inflammatory control, oxidative stress responses, angiogenesis, and neurovascular homeostasis, providing a biological basis for its potential involvement in the retinal and choroidal circulation. This narrative review synthesizes evidence from studies investigating associations between serum 25-hydroxyvitamin D [25(OH)D] concentrations and ocular vascular parameters assessed using optical coherence tomography (OCT), OCT angiography (OCTA), and retinal vascular imaging. Evidence from adult and pediatric populations generally associated vitamin D deficiency (VDD) with lower vessel density in the superficial and deep capillary plexuses, altered retinal vascular caliber and foveal avascular zone morphology, and reduced choroidal thickness or vascularity. However, the direction and magnitude of retinal OCTA findings were inconsistent, and conventional retinal structural measurements frequently remained unchanged. Supplementation studies reported relatively consistent increases in choroidal thickness and vascularity, whereas retinal perfusion responses were limited. Preliminary studies suggested that correction of VDD might support a more sustained response to bevacizumab in diabetic macular edema and central retinal vein occlusion, although this effect was not demonstrated consistently across retinal vascular diseases. Lower 25(OH)D concentrations were also more frequent among patients with retinal vascular occlusions, but residual systemic vascular confounding limits causal interpretation. Overall, current evidence supports a biologically plausible association between vitamin D status and ocular microvascular health but does not establish causality, functional visual benefit, or a specific therapeutic indication for supplementation. Longitudinal multicenter studies and randomized trials using standardized imaging protocols, functional outcomes, biochemical confirmation of vitamin D correction, and validated automated image analysis are required to determine the clinical relevance and reversibility of these findings. FAU - Tarasi, Tudor Corneliu AU - Tarasi TC AUID- ORCID: 0009-0002-7275-4285 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Donica, Vlad Constantin AU - Donica VC AUID- ORCID: 0000-0002-8814-3932 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Cianga, Vlad-Andrei AU - Cianga VA AUID- ORCID: 0000-0003-3215-2562 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Anita, Dragos-Constantin AU - Anita DC AUID- ORCID: 0000-0001-5463-6651 AD - Ion Ionescu de la Brad Iasi University of Life Sciences, 700490 Iasi, Romania. FAU - Lazar, Mircea AU - Lazar M AUID- ORCID: 0000-0002-3876-8416 AD - Ion Ionescu de la Brad Iasi University of Life Sciences, 700490 Iasi, Romania. FAU - Tirnovanu, Stefan-Dragos AU - Tirnovanu SD AUID- ORCID: 0009-0006-2624-8890 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Branisteanu, Daciana Elena AU - Branisteanu DE AUID- ORCID: 0009-0004-5954-1159 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. AD - Department of Dermatology, Cai Ferate Clinical Hospital, 700506 Iasi, Romania. FAU - Alexa, Anisia Iuliana AU - Alexa AI AUID- ORCID: 0000-0002-4226-3779 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. FAU - Branisteanu, Daniel-Constantin AU - Branisteanu DC AUID- ORCID: 0009-0009-5147-9596 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700115 Iasi, Romania. AD - Department of Ophthalmology, Cai Ferate Clinical Hospital, 700506 Iasi, Romania. LA - eng GR - Grigore T. Popa University of Medicine and Pharmacy/ PT - Journal Article PT - Review DEP - 20260914 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Humans MH - *Vitamin D Deficiency/complications/blood MH - Vitamin D/analogs & derivatives/blood MH - *Retinal Vessels/diagnostic imaging/pathology MH - Tomography, Optical Coherence MH - *Choroid/blood supply/diagnostic imaging MH - *Retinal Diseases/etiology MH - Child MH - Dietary Supplements MH - Adult PMC - PMC13610918 OTO - NOTNLM OT - choroidal vasculature OT - optical coherence tomography angiography OT - retinal microvasculature OT - vessel density OT - vitamin D deficiency COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/14 CRDT- 2026/09/26 01:15 PHST- 2026/08/10 00:00 [received] PHST- 2026/09/10 00:00 [revised] PHST- 2026/09/10 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:15 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - nu18183006 [pii] AID - nutrients-18-03006 [pii] AID - 10.3390/nu18183006 [doi] PST - epublish SO - Nutrients. 2026 Sep 14;18(18):3006. doi: 10.3390/nu18183006. PMID- 42796979 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 13 TI - Biochemical-Anthropometric Indices Assessing Liver Steatosis Identified in Elastography in Children with Metabolic DysFunction-Associated Steatotic Liver Disease. LID - 10.3390/nu18182996 [doi] LID - 2996 AB - Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of liver pathology in children. Hepatic fat content can be assessed by a transient elastography, but this method is not widely used. Therefore, the aim of this study was to evaluate the usefulness of a simple, surrogate biochemical-anthropometric indices of liver steatosis: FLI (Fatty Liver Index), HSI (Hepatic Steatosis Index), and LAP (Lipid Accumulation Product) in children with MASLD. Methods: The retrospective study included a group of 103 obese/overweight children. MASLD was diagnosed according to criteria developed by a multisociety statement published in Journal of Pediatric Gastroenterology and Nutrition in 2024. Liver steatosis (controlled attenuation parameter/CAP/) was assessed in elastography. HSI, FLI, and LAP were calculated according to their mathematical formulas. ROC analysis and multivariate logistic regression were performed to calculate the power of the studied indices in diagnostics of liver steatosis in children with MASLD. Results: MASLD was diagnosed in 72 children (70%). Children with MASLD had significantly higher levels of ALT, AST, GGT, uric acid, value of BMI, waist circumference, HOMA-IR, and indices HSI, FLI, LAP compared to the group of non-hepatopathic controls (n = 31). HSI, FLI, and LAP significantly correlated with CAP. All indices identified MASLD in the ROC analysis (AUC = 0.77, 0.76, 0.68 resp.). However, only HSI remained a significant independent predictor of hepatic steatosis in overweight/obese children. Conclusions: Although HSI, FLI, and LAP can be considered as useful biochemical-anthropometric indicators of MASLD in obese/overweight children, only HSI remained an independent predictor of hepatic steatosis in this group of children. FAU - Motkowska, Aleksandra M AU - Motkowska AM AD - Students' Scientific Association Affiliated with the Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Lebensztejn, Anna AU - Lebensztejn A AUID- ORCID: 0009-0006-2212-2588 AD - Students' Scientific Association Affiliated with the Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Tuchlinski, Bartosz AU - Tuchlinski B AD - Students' Scientific Association Affiliated with the Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Trochimczyk, Kinga AU - Trochimczyk K AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Flisiak-Jackiewicz, Marta AU - Flisiak-Jackiewicz M AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Bobrus-Chociej, Anna AU - Bobrus-Chociej A AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Rogalska, Magdalena AU - Rogalska M AD - Department of Infectious Diseases and Hepatology, Medical University of Bialystok, Zurawia Street 14, 15-540 Bialystok, Poland. FAU - Cudowska, Beata AU - Cudowska B AUID- ORCID: 0000-0002-8062-5865 AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Zdanowicz, Katarzyna AU - Zdanowicz K AUID- ORCID: 0000-0002-0755-911X AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Lebensztejn, Dariusz M AU - Lebensztejn DM AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. LA - eng GR - Grant No.: B.SUB.26.422/Medical University of Bialystok/ PT - Journal Article DEP - 20260913 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Child MH - Male MH - *Elasticity Imaging Techniques MH - Female MH - Retrospective Studies MH - *Fatty Liver/diagnosis/diagnostic imaging/etiology MH - Adolescent MH - *Anthropometry MH - Biomarkers/blood MH - ROC Curve MH - Liver/diagnostic imaging MH - Body Mass Index MH - Pediatric Obesity/complications PMC - PMC13609946 OTO - NOTNLM OT - children OT - controlled attenuation parameter OT - fatty liver index OT - hepatic steatosis index OT - lipid accumulation product OT - liver steatosis OT - metabolic dysfunction-associated steatotic liver disease OT - obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/27 02:27 PMCR- 2026/09/13 CRDT- 2026/09/26 01:14 PHST- 2026/08/10 00:00 [received] PHST- 2026/09/07 00:00 [revised] PHST- 2026/09/11 00:00 [accepted] PHST- 2026/09/27 02:27 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:14 [entrez] PHST- 2026/09/13 00:00 [pmc-release] AID - nu18182996 [pii] AID - nutrients-18-02996 [pii] AID - 10.3390/nu18182996 [doi] PST - epublish SO - Nutrients. 2026 Sep 13;18(18):2996. doi: 10.3390/nu18182996. PMID- 42796957 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261002 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 18 DP - 2026 Sep 11 TI - High Ultra-Processed Food Consumption but No Association with Quality of Life in Saudi Children and Adolescents with ADHD. LID - 10.3390/nu18182977 [doi] LID - 2977 AB - BACKGROUND/OBJECTIVES: Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by inattention, hyperactivity, and impulsivity. Dietary interventions can potentially control ADHD symptoms, providing a non-pharmacological approach that may improve the quality of life (QoL). This cross-sectional study aimed to assess the association between ultra-processed food intake (UPF) and QoL in children and adolescents with ADHD in Saudi Arabia. METHODS: A total of 128 participants (66% males and 33% females) diagnosed with ADHD, aged 8-18 years, were assessed. A validated Saudi food frequency questionnaire was used to assess dietary intake; the degree of food processing was assessed using a novel classification system. The health-related QoL was measured using the Pediatric Quality of Life Inventory. RESULTS: Both the child (57.83 +/- 18.12) and parent perspectives (57.97 +/- 16.09) of QOL scores were lower than those of healthy norms across all domains. (p-value < 0.0001). The UPF represented the largest proportion of total energy intake (48.76 +/- 13.40%), followed by unprocessed or minimally processed foods (39.80 +/- 13.35%). Parent- and child-reported QoL scores were strongly correlated (p < 0.0001); both were significantly lower than the healthy normative values across all domains (p < 0.0001). Higher parental educational attainment was associated with better QoL scores from both the child's and parents' perspectives (p = 0.049 and p = 0.023, respectively). CONCLUSIONS: Children and adolescents with ADHD demonstrated high consumption of UPF and significantly lower QoL scores than healthy norms. No significant association was observed between UPF intake and QoL scores. Further studies are needed to better understand the factors influencing dietary quality and QoL among children and adolescents with ADHD. FAU - Alwaili, Lina M AU - Alwaili LM AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. FAU - Alsuhaibani, Norah S AU - Alsuhaibani NS AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. FAU - Alotaibi, Heton K AU - Alotaibi HK AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. FAU - Alkhudairy, Loujain A AU - Alkhudairy LA AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. FAU - Alanezi, Hana A AU - Alanezi HA AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. FAU - Aljahdali, Abeer A AU - Aljahdali AA AUID- ORCID: 0000-0003-3104-1019 AD - Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, P.O. Box 80215, Jeddah 21589, Saudi Arabia. AD - Department of Nutritional Sciences, University of Michigan, Ann Arbor, MI 48109, USA. FAU - Alshamri, Dalal F AU - Alshamri DF AUID- ORCID: 0000-0003-1516-4705 AD - Department of Clinical Nutrition, King Abdullah bin Abdulaziz University Hospital, P.O. Box 84428, Riyadh 11564, Saudi Arabia. FAU - Alzaben, Abeer S AU - Alzaben AS AUID- ORCID: 0000-0001-9813-1524 AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. LA - eng GR - PNURSP2026R207/Princess Nourah bint Abdulrahman University/ PT - Journal Article DEP - 20260911 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - *Attention Deficit Disorder with Hyperactivity/psychology MH - *Quality of Life MH - Saudi Arabia MH - Humans MH - Male MH - Female MH - Child MH - Adolescent MH - Cross-Sectional Studies MH - *Eating/psychology MH - Diet Surveys MH - *Diet/adverse effects/statistics & numerical data MH - *Fast Foods/adverse effects/classification/statistics & numerical data PMC - PMC13610857 OTO - NOTNLM OT - NOVA OT - adolescents OT - attention-deficit hyperactivity disorder OT - quality of life OT - ultra-processed food COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/27 02:27 PMCR- 2026/09/11 CRDT- 2026/09/26 01:14 PHST- 2026/08/17 00:00 [received] PHST- 2026/09/05 00:00 [revised] PHST- 2026/09/08 00:00 [accepted] PHST- 2026/09/27 02:27 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:14 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - nu18182977 [pii] AID - nutrients-18-02977 [pii] AID - 10.3390/nu18182977 [doi] PST - epublish SO - Nutrients. 2026 Sep 11;18(18):2977. doi: 10.3390/nu18182977. PMID- 42795970 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 18 DP - 2026 Sep 16 TI - Developmental Postural Modeling: A Historical and Conceptual Narrative Review of Posture Assessment. LID - 10.3390/jcm15187197 [doi] LID - 7197 AB - Background: Posture assessment has progressed from visual observation and descriptive classification to quantitative measurement, three-dimensional imaging, and artificial intelligence (AI)-assisted analyses. Despite these advances, uncertainty persists regarding normative interpretation, developmental significance, and prognosis, particularly during growth and maturation phases. Methods: This historical and conceptual narrative review synthesizes literature from PubMed/MEDLINE, Scopus, Web of Science, Google Scholar, and Semantic Scholar, with additional citation tracking and targeted searches of historical monographs and foundational sources. The final literature search was completed on 30 May 2026. The review was narrative rather than systematic, and no formal risk-of-bias or evidence-quality appraisal was performed. Reporting and methodological transparency were strengthened by referencing the SANRA principles for narrative reviews. Results: The literature supports several overlapping methodological traditions: observation and classification, quantitative measurement, three-dimensional reconstruction, and automated image- and data-based analysis. These approaches have accumulated rather than replaced one another. Across these traditions, a persistent measurement-interpretation gap remains: postural configuration can be characterized by increasing precision, whereas developmental reference trajectories and prognostic interpretations remain limited. Conclusions: Developmental Postural Modeling (DPM) is proposed as a hypothesis-generating conceptual framework for future research, initially emphasizing posture during childhood and adolescence, when growth and maturation are most explicit. The DPM is not a validated clinical tool and does not currently provide individual predictions or treatment recommendations. Its proposed role is to organize future longitudinal research integrating morphology, function, development, environment, time, advanced imaging, and computational analysis. FAU - Glinkowski, Wojciech Michal AU - Glinkowski WM AUID- ORCID: 0000-0003-2602-1128 AD - Center of Excellence "TeleOrto" for Telediagnostics and Treatment of Disorders and Injuries of the Locomotor System, Department of Medical Informatics and Telemedicine, Medical University of Warsaw, 02-091 Warsaw, Poland. AD - Polish Telemedicine and eHealth Society, 03-728 Warsaw, Poland. FAU - Sitnik, Robert AU - Sitnik R AUID- ORCID: 0000-0002-8156-5462 AD - Faculty of Mechatronics, Warsaw University of Technology, ul. sw. Andrzeja Boboli 8, 02-525 Warsaw, Poland. LA - eng PT - Journal Article PT - Review DEP - 20260916 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13607638 OTO - NOTNLM OT - anthropometry OT - artificial intelligence OT - auxology OT - body posture OT - developmental trajectories OT - postural development OT - posture classification OT - rasterstereography OT - spinal sagittal alignment OT - surface topography OT - three-dimensional reconstruction COIS- The authors declare no conflict of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/16 CRDT- 2026/09/26 01:12 PHST- 2026/06/21 00:00 [received] PHST- 2026/08/17 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:12 [entrez] PHST- 2026/09/16 00:00 [pmc-release] AID - jcm15187197 [pii] AID - jcm-15-07197 [pii] AID - 10.3390/jcm15187197 [doi] PST - epublish SO - J Clin Med. 2026 Sep 16;15(18):7197. doi: 10.3390/jcm15187197. PMID- 42795335 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2075-1729 (Print) IS - 2075-1729 (Electronic) IS - 2075-1729 (Linking) VI - 16 IP - 9 DP - 2026 Sep 2 TI - Inter-Rater Reliability of the Progressive Pain Check Method for Standardized Pain Assessment in Lipedema. LID - 10.3390/life16091471 [doi] LID - 1471 AB - BACKGROUND: Lipedema is a chronic progressive condition affecting approximately 10% of women, characterized by disproportionate subcutaneous adipose tissue accumulation and pain in the lower extremities. Standardized assessment methods for pain evaluation in lipedema remain limited. The Progressive Pain Check (PPC) method represents a potentially valuable tool for standardized pain assessment in lipedema patients. OBJECTIVE: To evaluate the inter-rater reliability of the PPC method for clinical assessment of evoked pain in lipedema patients. METHODS: Two independent assessors performed PPC evaluations. Inter-rater reliability was assessed using the Intraclass Correlation Coefficient [ICC(2,1), two-way random-effects, absolute agreement, single-measurement] with 95% confidence intervals (CI). RESULTS: This study included 429 women diagnosed with lipedema (mean age 41.2 +/- 11.5 years, mean disease duration 27.2 +/- 12.6 years). Patient characteristics revealed mean BMI of 29.5 +/- 6.9 kg/m(2), predominantly Type III lipedema presentation, and disease onset during adolescence (mean age 14 +/- 9.3 years). The PPC method demonstrated excellent inter-rater reliability between two independent assessors across all examined anatomical districts. CONCLUSIONS: The PPC method shows promise as a simple, repeatable, and standardized clinical tool for evoked pain assessment in lipedema patients. The demonstrated inter-rater reliability supports its potential utility in clinical practice. Further research is warranted to evaluate its intra-rater reliability, concurrent validity, and responsiveness in monitoring treatment effects. FAU - Patton, Laura AU - Patton L AUID- ORCID: 0009-0008-2024-4607 AD - Endocrinology and Lymphology Clinic, 38096 Vallelaghi, Italy. FAU - Ricolfi, Lorenzo AU - Ricolfi L AUID- ORCID: 0009-0000-7216-9612 AD - Endocrinology and Lymphology Clinic, 38096 Vallelaghi, Italy. FAU - Elhadidy, Heba Safwat Mhmoued Abdo AU - Elhadidy HSMA AUID- ORCID: 0000-0002-8425-8580 AD - Department of Public Health Sciences and Paediatrics, University of Turin, 10126 Torino, Italy. FAU - Reverdito, Valeria AU - Reverdito V AD - Human Project Studio, 10138 Torino, Italy. FAU - Russotto, Antonino AU - Russotto A AUID- ORCID: 0000-0002-5925-2240 AD - Department of Public Health Sciences and Paediatrics, University of Turin, 10126 Torino, Italy. FAU - Politano, Gianfranco AU - Politano G AUID- ORCID: 0000-0001-5268-9899 AD - Department of Control and Computer Engineering, Politecnico di Torino, 10129 Torino, Italy. FAU - Gianino, Maria Michela AU - Gianino MM AD - Department of Public Health Sciences and Paediatrics, University of Turin, 10126 Torino, Italy. LA - eng PT - Journal Article DEP - 20260902 PL - Switzerland TA - Life (Basel) JT - Life (Basel, Switzerland) JID - 101580444 PMC - PMC13608010 OTO - NOTNLM OT - allodynia OT - clinical OT - examination OT - inter-rater reliability OT - lipedema OT - pain assessment COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/02 CRDT- 2026/09/26 01:10 PHST- 2026/07/21 00:00 [received] PHST- 2026/08/29 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:10 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - life16091471 [pii] AID - life-16-01471 [pii] AID - 10.3390/life16091471 [doi] PST - epublish SO - Life (Basel). 2026 Sep 2;16(9):1471. doi: 10.3390/life16091471. PMID- 42794587 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 27 IP - 18 DP - 2026 Sep 13 TI - Obesity, Oxidative Stress, and Inflammation in Precocious Puberty: Do All Roads Lead to the Hypothalamus? LID - 10.3390/ijms27188159 [doi] LID - 8159 AB - Childhood obesity is consistently associated with earlier pubertal timing, particularly in girls, whereas its relationship with true central precocious puberty (CPP), defined by premature activation of the hypothalamic-pituitary-gonadal (HPG) axis, is less clearly established. An increased frequency of CPP diagnoses and referrals was reported during the COVID-19 pandemic, alongside changes in body weight, lifestyle, sleep, and psychosocial exposures. Human studies link excess adiposity to hyperleptinemia, insulin resistance, reduced adiponectin, altered sex-steroid bioavailability, and systemic low-grade inflammation, and associate these features with earlier pubertal development-consistently in girls, less so in boys. However, such associations do not establish that obesity directly induces premature hypothalamic activation. Mechanistic understanding of how these peripheral signals may influence pubertal timing derives predominantly from experimental models. The arcuate nucleus kisspeptin/neurokinin B/dynorphin (KNDy) network, a key component of the gonadotropin-releasing hormone (GnRH) pulse generator, interacts with hypothalamic metabolic circuits. In animal models of obesity and overnutrition, altered leptin and insulin signaling, mitochondrial reactive oxygen species generation, and activation of microglia and astrocytes remodel the mediobasal hypothalamus through inflammatory and stress-responsive pathways, including IKKbeta/NF-kappaB and JNK signaling and altered Nrf2-mediated antioxidant defenses. At the molecular level, metabolic status interacts with the epigenetic machinery governing Kiss1 expression: in rodent models of overnutrition, accelerated loss of SIRT1-mediated repression at the Kiss1 promoter facilitates pubertal activation. Human genetic evidence establishes MKRN3 and DLK1 as causes of familial CPP, but evidence that obesity modifies these pathways to induce sporadic CPP is insufficient. Similarly, gut microbial metabolites have been linked experimentally to pubertal timing, and antioxidant micronutrients such as selenium, zinc, and vitamins C and E may be altered in pediatric obesity, yet a specific role in CPP remains unproven. Collectively, current evidence supports a working model in which metabolic, inflammatory, redox, glial, and epigenetic pathways may converge on hypothalamic reproductive circuits to influence pubertal timing in susceptible children. Direct evidence in children with CPP-of hypothalamic oxidative stress, glial activation, Nrf2 dysfunction, SIRT1 remodeling, or microbiome-mediated activation-remains limited or absent. Lifestyle optimization is appropriate for improving metabolic health in children with obesity, whereas antioxidant, micronutrient, and microbiome-targeted interventions should be considered investigational with respect to CPP. Longitudinal pediatric studies that distinguish earlier pubertal timing from true CPP, and that integrate metabolic phenotyping with validated measures of HPG-axis activation, are needed to test this framework. FAU - Bizerea-Moga, Teofana-Otilia AU - Bizerea-Moga TO AUID- ORCID: 0000-0002-1599-5579 AD - Department XI of Pediatrics, First Pediatric University Clinic, Center for Research on Growth and Developmental Disorders in Children, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. AD - 1st Pediatric Clinic, 'Louis Turcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania. FAU - Chisavu, Flavia AU - Chisavu F AD - Nephrology University Clinic, Centre for Molecular Research in Nephrology and Vascular Disease, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. AD - 4th Pediatric Clinic, 'Louis Turcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania. FAU - Chisavu, Lazar AU - Chisavu L AUID- ORCID: 0000-0003-3664-1945 AD - Nephrology University Clinic, Centre for Molecular Research in Nephrology and Vascular Disease, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. AD - Nephrology Clinic, 'Pius Brinzeu' County Emergency Clinical Hospital, Liviu Rebreanu 156, 300723 Timisoara, Romania. FAU - Pitulice, Laura AU - Pitulice L AUID- ORCID: 0000-0002-5991-6203 AD - Department of Chemistry, West University of Timisoara, Pestallozi 16, 300115 Timisoara, Romania. AD - Institute of Advanced Environmental Research, Oituz 4c, 300086 Timisoara, Romania. FAU - Moga, Tudor Voicu AU - Moga TV AUID- ORCID: 0000-0002-8978-1856 AD - Department VII of Internal Medicine, Gastroenterology University Clinic, Advanced Regional Research Center in Gastroenterology and Hepatology, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. AD - Gastroenterology and Hepatology Clinic, 'Pius Brinzeu' County Emergency Clinical Hospital, Liviu Rebreanu 156, 300723 Timisoara, Romania. FAU - Bugi, Meda-Ada AU - Bugi MA AD - 1st Pediatric Clinic, 'Louis Turcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania. AD - Department of Pharmacy, University of Medicine and Pharmacy 'Vasile Goldis', 310025 Arad, Romania. FAU - Foghis, Cornel Flavius AU - Foghis CF AUID- ORCID: 0009-0009-4621-274X AD - Department XI of Pediatrics, First Pediatric University Clinic, Center for Research on Growth and Developmental Disorders in Children, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. AD - 1st Pediatric Clinic, 'Louis Turcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania. AD - Ph.D. School Department, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. FAU - Isac, Raluca AU - Isac R AUID- ORCID: 0000-0003-1478-9797 AD - 4th Pediatric Clinic, 'Louis Turcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania. AD - Department XI of Pediatrics, Third Pediatric University Clinic, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. FAU - Marginean, Otilia AU - Marginean O AUID- ORCID: 0000-0003-2313-7643 AD - Department XI of Pediatrics, First Pediatric University Clinic, Center for Research on Growth and Developmental Disorders in Children, 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Sq No. 2, 300041 Timisoara, Romania. AD - 1st Pediatric Clinic, 'Louis Turcanu' Children's Clinical and Emergency Hospital, Iosif Nemoianu 2, 300011 Timisoara, Romania. FAU - Balica, Nicolae Constantin AU - Balica NC AUID- ORCID: 0000-0001-7755-4608 AD - Department IX, Otolaryngology University Clinic, OftalmoSensory-Tumor Research Center-ORL (EYE-ENT), 'Victor Babes' University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania. AD - Otorhinolaryngology Clinic, Emergency City Hospital, 300054 Timisoara, Romania. LA - eng PT - Journal Article PT - Review DEP - 20260913 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 SB - IM MH - Humans MH - *Puberty, Precocious/metabolism/pathology/etiology MH - *Oxidative Stress MH - Animals MH - *Inflammation/metabolism/complications MH - *Hypothalamus/metabolism/pathology MH - *Obesity/metabolism/complications MH - Hypothalamic-Pituitary-Gonadal Axis MH - Female PMC - PMC13607323 OTO - NOTNLM OT - KNDy neurons OT - hypothalamus OT - neuroinflammation OT - obesity OT - oxidative stress OT - precocious puberty COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/13 CRDT- 2026/09/26 01:08 PHST- 2026/07/22 00:00 [received] PHST- 2026/09/08 00:00 [revised] PHST- 2026/09/10 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:08 [entrez] PHST- 2026/09/13 00:00 [pmc-release] AID - ijms27188159 [pii] AID - ijms-27-08159 [pii] AID - 10.3390/ijms27188159 [doi] PST - epublish SO - Int J Mol Sci. 2026 Sep 13;27(18):8159. doi: 10.3390/ijms27188159. PMID- 42794468 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260929 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 27 IP - 18 DP - 2026 Sep 9 TI - Targeted 3.34-Million CpG Site Sequencing Reveals Preliminary Cord Blood Epigenetic Alterations of Autism Spectrum Disorder: A Pilot Study Highlighting the PCDHA1-PCDHA8 Cluster. LID - 10.3390/ijms27188038 [doi] LID - 8038 AB - Rising reported Autism Spectrum Disorder (ASD) prevalence underscores the need to explore early perinatal biological markers. To conduct an exploratory pilot investigation of cord blood DNA methylation patterns as potential early epigenetic candidate loci associated with ASD in infants born to mothers with obesity and gestational diabetes. This prospective pilot study analyzed 14 mother-infant pairs comprising infants born to mothers with obesity and gestational diabetes later diagnosed with ASD (n = 2); healthy infants born to mothers with obesity and diabetes (IODM, n = 6); and healthy controls (IHM, n = 6). Targeted methyl-capture sequencing (covering 3.34 million CpG sites) identified differentially methylated region (DMR)-associated genes. Neurodevelopment was evaluated at 24-26 months using Bayley-III scales. ASD infants showed lower Bayley-III scores across all domains. In this small cohort (n = 2 ASD cases), we identified 249 DMR-associated genes common to both ASD vs. IHM and ASD vs. IODM comparisons, representing preliminary candidate loci. Enrichment analysis identified homophilic cell-cell adhesion as the most significant pathway (fold enrichment = 8.28; FDR = 6.31 x 10(-6)), driven by the PCDH1-PCDHA8 cluster, alongside morphogenesis in neuron differentiation (fold enrichment = 3.45; FDR = 2.08 x 10(-2)). Although prospective validation in larger independent cohorts is required, these pilot results suggest that cord blood PCDHA1-PCDHA8 cluster methylation alterations represent preliminary candidate loci for hypothesis generation and future biomarker evaluation, regardless of maternal metabolic status. FAU - Armas-Gonzalez, Marina AU - Armas-Gonzalez M AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. AD - Department of Child and Adolescent Psychiatry, Hospital General Universitario Gregorio Maranon, 28007 Madrid, Spain. FAU - Gonzalez-Gonzalez, Nieves Luisa AU - Gonzalez-Gonzalez NL AUID- ORCID: 0000-0003-1401-5580 AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. FAU - Gonzalez-Davila, Enrique AU - Gonzalez-Davila E AUID- ORCID: 0000-0002-0781-9161 AD - Mathematics, Statistics and Operations Research Department (IMAULL), University of La Laguna (ULL), 38320 La Laguna, Spain. FAU - Orribo-Morales, Olivia AU - Orribo-Morales O AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. AD - Department of Obstetrics and Gynecology, Canary Islands University Hospital, 38320 La Laguna, Spain. FAU - Castro-Conde, Jose Ramon AU - Castro-Conde JR AUID- ORCID: 0000-0003-0867-2920 AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. AD - Pediatrics Department, Canary Islands University Hospital, 38320 La Laguna, Spain. FAU - Gonzalez-Campos, Candelaria AU - Gonzalez-Campos C AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. AD - Pediatrics Department, Canary Islands University Hospital, 38320 La Laguna, Spain. FAU - Flores, Carlos AU - Flores C AUID- ORCID: 0000-0001-5352-069X AD - Research Unit, Hospital Universitario Ntra. Sra. de Candelaria, Instituto de Investigacion Sanitaria de Canarias (IISC), 38010 Santa Cruz de Tenerife, Spain. AD - CIBER de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Genomics Division, Instituto Tecnologico y de Energias Renovables (ITER), 38600 Santa Cruz de Tenerife, Spain. FAU - Lorenzo-Salazar, Jose Miguel AU - Lorenzo-Salazar JM AUID- ORCID: 0000-0002-5135-2861 AD - Genomics Division, Instituto Tecnologico y de Energias Renovables (ITER), 38600 Santa Cruz de Tenerife, Spain. FAU - Gonzalez-Montelongo, Rafaela AU - Gonzalez-Montelongo R AUID- ORCID: 0000-0001-9022-8663 AD - Genomics Division, Instituto Tecnologico y de Energias Renovables (ITER), 38600 Santa Cruz de Tenerife, Spain. FAU - Munoz-Barrera, Adrian AU - Munoz-Barrera A AUID- ORCID: 0000-0002-1561-5898 AD - Genomics Division, Instituto Tecnologico y de Energias Renovables (ITER), 38600 Santa Cruz de Tenerife, Spain. FAU - Padron-Perez, Erika AU - Padron-Perez E AUID- ORCID: 0000-0001-5243-3244 AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. AD - Department of Obstetrics and Gynecology, Canary Islands University Hospital, 38320 La Laguna, Spain. FAU - Tascon-Padron, Laura AU - Tascon-Padron L AUID- ORCID: 0000-0001-9941-9001 AD - Department of Obstetrics and Prenatal Medicine, University Hospital Bonn, 53127 Bonn, Germany. FAU - Nunez Catalan, Maria AU - Nunez Catalan M AD - Obstetrics and Gynecology Department, Seccion de Medicina, Facultad de Ciencias de la Salud, University of La Laguna (ULL), 38320 La Laguna, Spain. LA - eng GR - PI18/01700/Instituto de Salud Carlos III/ PT - Journal Article DEP - 20260909 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - 0 (Cadherins) SB - IM MH - Humans MH - *Fetal Blood/metabolism MH - Female MH - Pilot Projects MH - *DNA Methylation MH - *Epigenesis, Genetic MH - *CpG Islands/genetics MH - *Autism Spectrum Disorder/genetics MH - Pregnancy MH - *Cadherins/genetics MH - Male MH - Diabetes, Gestational/genetics MH - Prospective Studies MH - Adult MH - Case-Control Studies MH - Infant PMC - PMC13607789 OTO - NOTNLM OT - DNA OT - autism OT - cord blood OT - diabetes OT - enrichment analysis OT - epigenetic OT - maternal obesity OT - neurodevelopment OT - pregnancy OT - protocadherins COIS- The authors declare no conflict of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/09 CRDT- 2026/09/26 01:07 PHST- 2026/07/30 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:07 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - ijms27188038 [pii] AID - ijms-27-08038 [pii] AID - 10.3390/ijms27188038 [doi] PST - epublish SO - Int J Mol Sci. 2026 Sep 9;27(18):8038. doi: 10.3390/ijms27188038. PMID- 42794262 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 9 DP - 2026 Sep 14 TI - Biomarkers of Treatment-Escalation Risk by Obesity Status in Pediatric Asthma: A Development and External Validation Cohort Study. LID - 10.3390/children13091242 [doi] LID - 1242 AB - Background/Objectives: Obesity may alter the prognostic value of biomarkers in childhood asthma. We examined whether transforming growth factor beta 1 (TGF-beta1), soluble suppression of tumorigenicity 2 (sST2), C-X-C motif chemokine ligand 8 (CXCL8), and insulin-like growth factor 1 (IGF-1) were associated with sustained treatment escalation and whether associations differed by obesity status. Methods: The development cohort included 292 children: 90 non-atopic controls, 108 with normal-weight asthma, and 94 with obese asthma; longitudinal analyses included 202 with asthma. Biomarkers were modeled continuously in prespecified Cox models with biomarker-by-obesity interactions, internally validated with 1000 bootstrap resamples, and applied without refitting or recalibration to an independent Van cohort of 180 children with asthma. Results: Seventy-five children experienced sustained treatment escalation. TGF-beta1 was associated with escalation in obese asthma (hazard ratio [HR] per 500 pg/mL, 2.12; 95% confidence interval [CI], 1.66-2.70; interaction q < 0.001), whereas CXCL8 was associated with escalation in normal-weight asthma (HR per 10 pg/mL, 2.06; 95% CI, 1.67-2.54; interaction q < 0.001). Adding TGF-beta1 or CXCL8 increased 12-month time-dependent area under the curve (AUC) from 0.623 to 0.732 and 0.746. In Van, AUCs were 0.751 and 0.744, and interactions remained significant after adjustment (q = 0.036). sST2 showed a weaker obesity-related signal, whereas IGF-1 added little prognostic information. Conclusions: Prognostic biomarker associations differed by obesity status. TGF-beta1 was associated with escalation in obese asthma, whereas CXCL8 was associated with escalation in normal-weight asthma. Further validation is needed before clinical use. FAU - Goktas, Serdar AU - Goktas S AUID- ORCID: 0000-0002-5738-4979 AD - Department of Pediatrics, Clinic of Pediatric Immunology and Allergy, Mersin City Training and Research Hospital, 33240 Mersin, Turkiye. AD - Department of Pediatrics, Clinic of Pediatric Immunology and Allergy, Van Training and Research Hospital, 65300 Van, Turkiye. FAU - Kaya, Mehmet Sirin AU - Kaya MS AUID- ORCID: 0000-0001-9416-9058 AD - Department of Pediatrics, Clinic of Pediatric Immunology and Allergy, Sanliurfa Training and Research Hospital, 63200 Sanliurfa, Turkiye. LA - eng PT - Journal Article DEP - 20260914 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13605966 OTO - NOTNLM OT - CXCL8 OT - TGF-beta1 OT - childhood obesity OT - external validation OT - pediatric asthma OT - prognostic model OT - treatment escalation COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/14 CRDT- 2026/09/26 01:07 PHST- 2026/08/09 00:00 [received] PHST- 2026/09/06 00:00 [revised] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:07 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - children13091242 [pii] AID - children-13-01242 [pii] AID - 10.3390/children13091242 [doi] PST - epublish SO - Children (Basel). 2026 Sep 14;13(9):1242. doi: 10.3390/children13091242. PMID- 42794233 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 9 DP - 2026 Sep 8 TI - Risk Factors Influencing Neurodevelopmental Outcome and Survival in Preterm Infants: A Prospective Cohort Study. LID - 10.3390/children13091214 [doi] LID - 1214 AB - BACKGROUND/OBJECTIVES: Survival of infants born very preterm or with very low birth weight has improved without a comparable reduction in neurodevelopmental morbidity, and the exposures acting during neonatal intensive care are usually studied in isolation. We aimed to identify which prenatal, perinatal and postnatal factors are independently associated, domain by domain, with neurodevelopment at 24 months' corrected age (CA) and with the composite outcome of neurodevelopment and survival. METHODS: Single-centre prospective cohort of 146 infants (135 assessed at 24 months' CA and 11 who died between day 8 of life and the assessment) with gestational age /= 0.50, without direct assessment of biochemical or hemodynamic parameters. Receiver operating characteristic (ROC) curves, optimal Youden-derived cut-offs, and internal bootstrap validation (1000 resamples) were performed. RESULTS: Anthropometric parameters demonstrated high discriminatory performance for detecting WHtR-defined surrogate risk across all sex and maturation cohorts (AUC = 0.88-0.98). Unadjusted physical fitness tests showed poor overall classification performance. However, normalizing fitness metrics for body mass (particularly relative CMJ and cardiorespiratory fitness) substantially improved discriminatory capacity. Optimal cut-off values for anthropometric indicators displayed an observed descending pattern across progressively later-maturing cohorts. CONCLUSIONS: Anthropometric parameters represent highly accurate field proxies for WHtR-defined surrogate risk screening in adolescents. While unadjusted fitness metrics have limited utility for this anthropometric outcome, body-mass-normalized fitness parameters substantially recover classification capacity. Biological maturation timing should be carefully considered when future research derives and externally validates adolescent screening thresholds, as current cut-offs remain exploratory and sample-derived. FAU - Lopez-Lombo, Victoria AU - Lopez-Lombo V AD - Research Group Movement Sciences and Sport (MS&SPORT), Department of Physical Activity and Sport Sciences, Faculty of Sport Sciences, University of Murcia, 30720 San Javier, Murcia, Spain. FAU - Mateo-Orcajada, Adrian AU - Mateo-Orcajada A AUID- ORCID: 0000-0001-8111-8358 AD - Research Group Movement Sciences and Sport (MS&SPORT), Department of Physical Activity and Sport Sciences, Faculty of Sport Sciences, University of Murcia, 30720 San Javier, Murcia, Spain. FAU - Abenza-Cano, Lucia AU - Abenza-Cano L AUID- ORCID: 0000-0001-9583-737X AD - Facultad de Deporte, UCAM Universidad Catolica San Antonio de Murcia, 30107 Guadalupe, Murcia, Spain. FAU - Abraldes, J Arturo AU - Abraldes JA AUID- ORCID: 0000-0003-4527-3865 AD - Research Group Movement Sciences and Sport (MS&SPORT), Department of Physical Activity and Sport Sciences, Faculty of Sport Sciences, University of Murcia, 30720 San Javier, Murcia, Spain. FAU - Albaladejo-Saura, Mario AU - Albaladejo-Saura M AUID- ORCID: 0000-0003-0234-7756 AD - Facultad de Deporte, UCAM Universidad Catolica San Antonio de Murcia, 30107 Guadalupe, Murcia, Spain. FAU - Vaquero-Cristobal, Raquel AU - Vaquero-Cristobal R AUID- ORCID: 0000-0003-2708-4817 AD - Research Group Movement Sciences and Sport (MS&SPORT), Department of Physical Activity and Sport Sciences, Faculty of Sport Sciences, University of Murcia, 30720 San Javier, Murcia, Spain. LA - eng GR - PID2022-140245OA-I00/Ministerio de Ciencia e Innovacion/ PT - Journal Article DEP - 20260905 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13605130 OTO - NOTNLM OT - ROC curves OT - WHtR-defined cardiometabolic risk OT - Youden index OT - adolescents OT - body composition OT - maturity status OT - physical fitness OT - sex COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/05 CRDT- 2026/09/26 01:07 PHST- 2026/08/09 00:00 [received] PHST- 2026/09/01 00:00 [revised] PHST- 2026/09/03 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:07 [entrez] PHST- 2026/09/05 00:00 [pmc-release] AID - children13091201 [pii] AID - children-13-01201 [pii] AID - 10.3390/children13091201 [doi] PST - epublish SO - Children (Basel). 2026 Sep 5;13(9):1201. doi: 10.3390/children13091201. PMID- 42794149 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 9 DP - 2026 Aug 24 TI - Associations Between 24-Hour Movement Behaviors and Anthropometric and Body Composition Indicators in Ecuadorian Preschool Children: SUNRISE Pilot Study. LID - 10.3390/children13091129 [doi] LID - 1129 AB - OBJECTIVE: To analyze associations between 24-hour movement behaviors (and guideline adherence) and anthropometric and body composition indicators in Ecuadorian preschoolers using data from the International Study of Movement Behaviors in the Early Years (SUNRISE) pilot study. METHODS: This secondary analysis utilized data from the primary study conducted in 108 children aged 3-4 years (57.4% girls; 50.9% urban). Anthropometry (weight, height, and body mass index [BMI]) was assessed using standardized protocols during the pilot study, whereas body composition indicators (fat-free mass [FFM], fat mass [FM], and body fat percentage) were estimated using a validated anthropometric prediction equation. Movement behaviors were assessed via triaxial accelerometry (ActiGraph GT3X+ or GT3X-BT, Pensacola, FL, USA) over seven days, complemented by parent-reported questionnaires. Exploratory unadjusted correlation analyses were performed using Spearman's rho (rho) for continuous/ordinal variables, and Pearson's correlations (r), mathematically equivalent to point-biserial correlations (r(pb)), for dichotomous-continuous associations. RESULTS: In exploratory unadjusted analyses, device-measured longer sleep duration showed small-to-moderate inverse associations with weight (rho = -0.33, p = 0.001), BMI (rho = -0.28, p = 0.006), and FFM (rho = -0.37, p < 0.001). Higher moderate-to-vigorous physical activity showed moderate positive associations with height (rho = 0.32, p = 0.002), weight (rho = 0.40, p < 0.001), and FFM (rho = 0.44, p < 0.001). In complementary multivariable models, the associations between device-measured sleep or moderate-to-vigorous physical activity (MVPA) and the pre-specified anthropometric and body composition outcomes were attenuated after adjustment for age, sex, area of residence, and, where applicable, height, and were generally not statistically significant. CONCLUSIONS: In this exploratory secondary analysis of the SUNRISE Pilot Study Ecuador, unadjusted analyses identified associations between specific 24-hour movement behaviors, particularly sleep duration and MVPA, and anthropometric and body composition indicators. However, these associations were attenuated after covariate adjustment. The findings should therefore be interpreted as hypothesis-generating and require confirmation in larger longitudinal studies. FAU - Cisneros-Vasquez, Emily AU - Cisneros-Vasquez E AD - School of Medicine, Universidad Espiritu Santo, Samborondon 0901952, Ecuador. AD - Department of Health Research, Icen Cognis, 38370 La Matanza de Acentejo, Spain. FAU - Jimenez-Lopez, Estela AU - Jimenez-Lopez E AUID- ORCID: 0000-0001-8553-7701 AD - Health and Social Research Center, Universidad de Castilla-La Mancha, 13071 Cuenca, Spain. AD - Department of Nursing, University of Castilla-La Mancha, 13071 Cuenca, Spain. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AUID- ORCID: 0000-0002-9311-6576 AD - Faculty of Education and Social Sciences, Universidad Andres Bello, Vina del Mar 8370035, Chile. FAU - Gutierrez-Espinoza, Hector AU - Gutierrez-Espinoza H AUID- ORCID: 0000-0002-4650-3426 AD - Faculty of Education, Universidad Autonoma de Chile, Santiago 7500912, Chile. FAU - Olivares-Arancibia, Jorge AU - Olivares-Arancibia J AD - AFySE Group, Research in Physical Activity and School Health, School of Physical Education, Faculty of Education, Universidad de las Americas, Santiago 7500975, Chile. FAU - Sanchez-Miguel, Pedro Antonio AU - Sanchez-Miguel PA AUID- ORCID: 0000-0002-1660-535X AD - Departamento de Didactica de la Expresion Musical, Plastica y Corporal, Grupo de Investigacion Analisis Didactico y Comportamental del Deporte (ADICODE), Facultad de Formacion del Profesorado, Universidad de Extremadura, 10003 Caceres, Spain. FAU - Rahmati, Masoud AU - Rahmati M AD - CEReSS-Health Service Research and Quality of Life Center, Aix-Marseille University, 13284 Marseille, France. AD - Clinical Research Unit, Delegation a la Recherche Clinique et a l'Innovation du GHT, Center Hospitalier Intercommunal de Toulon La Seyne-sur-Mer, 83100 Toulon, France. FAU - Yon, Dong Keon AU - Yon DK AUID- ORCID: 0000-0003-1628-9948 AD - Center for Digital Health, Medical Science Research Institute, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea. AD - Department of Precision Medicine, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea. AD - Department of Pediatrics, Kyung Hee University Medical Center, College of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea. FAU - Smith, Lee AU - Smith L AUID- ORCID: 0000-0002-5340-9833 AD - Centre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge CB1 1PT, UK. AD - Department of Public Health, Faculty of Medicine, Biruni University, Istanbul 34015, Turkey. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - School of Medicine, Universidad Espiritu Santo, Samborondon 0901952, Ecuador. AD - Faculty of Health Sciences, Universidad Tecnologica Atlantico Mediterraneo-UTAMED, 29590 Malaga, Spain. LA - eng GR - 2025-MED-009/Universidad Espiritu Santo/ PT - Journal Article DEP - 20260824 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13605536 OTO - NOTNLM OT - Ecuador OT - childhood OT - daily movement behaviors OT - obesity OT - physical activity OT - screen time OT - sleep COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/08/24 CRDT- 2026/09/26 01:06 PHST- 2026/07/14 00:00 [received] PHST- 2026/08/14 00:00 [revised] PHST- 2026/08/14 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:06 [entrez] PHST- 2026/08/24 00:00 [pmc-release] AID - children13091129 [pii] AID - children-13-01129 [pii] AID - 10.3390/children13091129 [doi] PST - epublish SO - Children (Basel). 2026 Aug 24;13(9):1129. doi: 10.3390/children13091129. PMID- 42793617 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 18 DP - 2026 Sep 19 TI - Effect of Nursing Intervention Supported by Mobile Health Applications on Asthma Control, Maternal and Neonatal Outcomes Among Pregnant Women with Asthma. LID - 10.3390/healthcare14183079 [doi] LID - 3079 AB - BACKGROUND: Asthma during pregnancy is associated with adverse maternal and neonatal outcomes. Nursing education, self-management support, and mobile health (mHealth) technologies may support asthma management during pregnancy. AIM: This study evaluated the effect of a structured nursing intervention supported by an mHealth application on asthma control, treatment adherence, and self-monitoring, and maternal and neonatal outcomes among pregnant women with asthma. DESIGN AND SETTING: A quasi-experimental pretest-posttest design with a control group was conducted at two Maternal and Child Health Centers in Shebin El-Kom, Menoufia Governorate, Egypt. PARTICIPANTS: A convenience sample of 140 pregnant women with physician-diagnosed asthma was recruited and allocated non-randomly according to the center attended to a study group (n = 70) and a control group (n = 70). The sample size was calculated a priori based on a previous study using a 5% significance level and 80% statistical power, with a 1:1 allocation ratio, resulting in a required sample of 70 participants per group. All recruited participants completed the study, with no withdrawals or loss to follow-up. INTERVENTION: The study group received routine antenatal care plus an eight-week structured nursing intervention consisting of four individualized weekly educational sessions (60-90 min each) addressing asthma management, medication adherence, self-monitoring, trigger avoidance, warning signs, inhaler technique, lifestyle modification, and rhythmic breathing exercises. Participants were trained to use the Airlyn mHealth application for guided breathing exercises, practiced 2-3 times daily, and received telephone/WhatsApp follow-up during weeks 6-8. The control group received routine antenatal care according to usual MCH center procedures. MEASURES: Asthma control was assessed using the Asthma Control Test (ACT). Treatment adherence and self-monitoring were assessed using the Asthma Adherence and Self-Monitoring Questionnaire. Maternal outcomes included hypertensive disorders, gestational diabetes, infections, preterm labor/PPROM, hemorrhage, and mode of delivery. Neonatal outcomes included birth weight, Apgar scores, respiratory distress and respiratory support, NICU admission and length of stay, and condition at discharge. The researcher-developed instruments underwent expert assessment of content validity and assessment of internal consistency before use. RESULTS: Baseline ACT scores were comparable between the study and control groups (14.5 +/- 4.2 vs. 14.1 +/- 4.3; mean difference = 0.4; p = 0.580). Following the intervention, ACT scores were higher in the study group than in the control group (19.7 +/- 3.6 vs. 15.2 +/- 4.2; mean difference = 4.5; 95% CI: 3.189-5.811; p < 0.001; Cohen's d = 1.147). Well-controlled asthma was observed in 75.7% of the study group compared with 17.1% of the control group (p < 0.001). Treatment adherence and self-monitoring scores were also better in the study group (5.6 +/- 2.7 vs. 9.1 +/- 3.1; mean difference = -3.5; 95% CI: -4.476 to -2.524; p < 0.001; Cohen's d = 1.199). The overall maternal outcome score was more favorable in the study group (3.5 +/- 1.7 vs. 6.1 +/- 2.6; mean difference = -2.6; 95% CI: -3.340 to -1.860; p < 0.001; Cohen's d = 1.174), as was the overall neonatal outcome score (7.7 +/- 2.2 vs. 5.5 +/- 2.1; mean difference = 2.2; 95% CI: 1.480-2.920; p < 0.001; Cohen's d = 1.022). Significant between-group differences were also observed in birth weight, Apgar scores, respiratory distress, and NICU admission. CONCLUSIONS: Participants who received the structured nursing intervention supported by the Airlyn mHealth application were associated with improved asthma control, treatment adherence, and self-monitoring, as well as more favorable maternal and neonatal outcomes, compared with those receiving routine antenatal care. However, the quasi-experimental design, convenience sampling, and non-randomized allocation limit causal interpretation and the generalizability of the findings. Therefore, the findings should be interpreted cautiously. RECOMMENDATIONS: Larger randomized controlled trials with standardized protocols, adequate sample sizes to evaluate maternal and neonatal outcomes, and longer follow-up periods are recommended to confirm these findings and further assess their clinical relevance. FAU - Nada, Hanan E AU - Nada HE AUID- ORCID: 0009-0008-8192-1384 AD - Maternal & Newborn Health Nursing, Faculty of Nursing, Menoufia University, Shibin Al Kawm 32511, Egypt. FAU - Mohamed, Ishraga Abdelgadir Ibrahim AU - Mohamed IAI AD - Critical Care Nursing, Department of Nursing, College of Applied Medical Sciences, University of Jeddah, Jeddah 21589, Saudi Arabia. FAU - Kandil, Faten Shawky AU - Kandil FS AUID- ORCID: 0000-0002-6471-5772 AD - Department of Nursing, College of Applied Medical Sciences, University of Jeddah, Jeddah 21589, Saudi Arabia. FAU - El-Bready, Hanan G AU - El-Bready HG AD - Community Health Nursing, Faculty of Nursing, Menoufia University, Shibin Al Kawm 32511, Egypt. FAU - Elsobkey, Fatma Ahmed AU - Elsobkey FA AUID- ORCID: 0000-0001-9881-1191 AD - Department of Nursing, College of Applied Medical Sciences, University of Jeddah, Jeddah 21589, Saudi Arabia. AD - Department of Pediatric Nursing, Faculty of Nursing, Benha University, Benha 13511, Egypt. FAU - Salem, Safaa Gaber Aly AU - Salem SGA AUID- ORCID: 0000-0001-5149-6403 AD - Department of Maternity, Obst & Gyn Nursing, College of Nursing, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. FAU - Shahin, Marwa A AU - Shahin MA AD - Nursing Program, Batterjee Medical College, Jeddah 21442, Saudi Arabia. FAU - Lotfy, Enas Mohamed AU - Lotfy EM AUID- ORCID: 0009-0003-1527-2666 AD - Leadership and Management Nursing, Public Health Nursing Department, Faculty of Nursing, Northern Border University, Arar 73213, Saudi Arabia. LA - eng GR - PNURSP2026R879/Princess Nourah bint Abdulrahman University/ GR - NBU-FFR-2026-3731-02/Northern Border University/ PT - Journal Article DEP - 20260919 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13606770 OTO - NOTNLM OT - Ailyn OT - asthma control OT - maternal outcomes OT - mobile health OT - neonatal outcomes OT - nursing intervention OT - pregnancy OT - self-monitoring OT - treatment adherence COIS- The authors declare no conflict of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/19 CRDT- 2026/09/26 01:05 PHST- 2026/07/19 00:00 [received] PHST- 2026/09/06 00:00 [revised] PHST- 2026/09/10 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:05 [entrez] PHST- 2026/09/19 00:00 [pmc-release] AID - healthcare14183079 [pii] AID - healthcare-14-03079 [pii] AID - 10.3390/healthcare14183079 [doi] PST - epublish SO - Healthcare (Basel). 2026 Sep 19;14(18):3079. doi: 10.3390/healthcare14183079. PMID- 42793457 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 18 DP - 2026 Sep 9 TI - Anthropometric Status, Menstrual Health, and Psychosocial Correlates Among 4251 Adolescent Girls in Kazakhstan: A School-Based Cross-Sectional Study. LID - 10.3390/healthcare14182918 [doi] LID - 2918 AB - BACKGROUND/OBJECTIVES: Menstrual health in adolescence is influenced by nutritional, developmental, and psychosocial factors, yet integrated school-based evidence from Central Asia is limited. We assessed recorded anthropometric, menstrual/reproductive, and psychosocial indicators among adolescent girls in southern Kazakhstan and evaluated factors associated with a prespecified composite menstrual/reproductive outcome. METHODS: We conducted a cross-sectional secondary analysis of a non-public school health screening database containing 5197 participant records from 2025. After removal of 946 exact duplicate copies, 4251 unique records of girls aged 12-18 years remained. We present prevalence estimates with Wilson 95% confidence intervals (CIs). We estimated adjusted prevalence ratios (aPRs) using modified Poisson regression with robust standard errors clustered by recorded school field. RESULTS: Mean age was 15.03 +/- 1.23 years and mean BMI was 20.36 +/- 3.36 kg/m(2). The source form used fixed adult BMI categories; these are reported descriptively and are not interpreted as pediatric nutritional diagnoses. At least one non-reference menstrual or reproductive indicator was recorded in 24.1% of participants; severe menstrual pain and stress were each recorded in 6.9%. Stress was associated with any menstrual/reproductive abnormality (aPR 2.05, 95% CI 1.65-2.54) and with severe menstrual pain (aPR 3.27, 95% CI 2.39-4.46). Unsatisfactory nutrition was also associated with the composite outcome (aPR 1.64, 95% CI 1.35-2.00). CONCLUSIONS: Recorded menstrual/reproductive concerns were frequent in this screened sample, and stress showed consistent associations with menstrual outcomes. Because anthropometric categories were based on adult cut points and several screening items were not validated instruments, interpret the findings as descriptive and hypothesis-generating rather than as population prevalence or causal estimates. FAU - Ayazbekov, Ardak AU - Ayazbekov A AD - Scientific Center of Obstetrics, Gynecology and Perinatology, 125 Dostyk Ave., 050010 Almaty, Kazakhstan. FAU - Terlikbayeva, Aigul AU - Terlikbayeva A AD - Scientific Center of Obstetrics, Gynecology and Perinatology, 125 Dostyk Ave., 050010 Almaty, Kazakhstan. FAU - Khaidarov, Saken AU - Khaidarov S AUID- ORCID: 0000-0001-7770-8427 AD - Scientific Center of Obstetrics, Gynecology and Perinatology, 125 Dostyk Ave., 050010 Almaty, Kazakhstan. AD - Department of Molecular Biology and Medical Genetics, Asfendiyarov Kazakh National Medical University, 37A Zheltoksan Street, 050004 Almaty, Kazakhstan. FAU - Baigazieva, Gulzhan AU - Baigazieva G AUID- ORCID: 0000-0003-1724-8419 AD - Scientific Center of Obstetrics, Gynecology and Perinatology, 125 Dostyk Ave., 050010 Almaty, Kazakhstan. FAU - Imanbaeva, Zhaysan AU - Imanbaeva Z AUID- ORCID: 0000-0003-4764-8149 AD - Scientific Center of Obstetrics, Gynecology and Perinatology, 125 Dostyk Ave., 050010 Almaty, Kazakhstan. FAU - Aimbetova, Aliya AU - Aimbetova A AD - Scientific Center of Obstetrics, Gynecology and Perinatology, 125 Dostyk Ave., 050010 Almaty, Kazakhstan. FAU - Kurmanova, Almagul AU - Kurmanova A AUID- ORCID: 0000-0002-1859-3903 AD - Faculty of Medicine and Healthcare, Al-Farabi Kazakh National University, 71 Al-Farabi Ave., 050040 Almaty, Kazakhstan. FAU - Salimbayeva, Damilya AU - Salimbayeva D AUID- ORCID: 0000-0002-7933-3654 AD - Scientific Center of Obstetrics, Gynecology and Perinatology, 125 Dostyk Ave., 050010 Almaty, Kazakhstan. LA - eng GR - BR27308739/Ministry of Health/ PT - Journal Article DEP - 20260909 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13606384 OTO - NOTNLM OT - Kazakhstan OT - adolescent health OT - body mass index OT - cross-sectional studies OT - dysmenorrhea OT - menstrual health OT - nutrition OT - psychosocial stress OT - school health services OT - underweight COIS- The authors declare no conflicts of interest. The funders had no role in the study design; data collection, analysis, or interpretation; manuscript preparation; or the decision to publish the results. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/09 CRDT- 2026/09/26 01:04 PHST- 2026/08/01 00:00 [received] PHST- 2026/08/27 00:00 [revised] PHST- 2026/09/07 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:04 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - healthcare14182918 [pii] AID - healthcare-14-02918 [pii] AID - 10.3390/healthcare14182918 [doi] PST - epublish SO - Healthcare (Basel). 2026 Sep 9;14(18):2918. doi: 10.3390/healthcare14182918. PMID- 42793423 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2076-3425 (Print) IS - 2076-3425 (Electronic) IS - 2076-3425 (Linking) VI - 16 IP - 9 DP - 2026 Sep 21 TI - Pediatric Mild Traumatic Brain Injury and Concussion: Modern Pathophysiological Insights, Diagnostic Advances, and Active Management Protocols. LID - 10.3390/brainsci16090998 [doi] LID - 998 AB - Traumatic brain injury and pediatric concussion represent major global public health concerns. This narrative review aims to provide an updated overview of pediatric concussion by integrating current evidence regarding pathophysiology, diagnostic advances, neuroimaging, biomarkers, and evidence-based management strategies. Concussion pathophysiology involves a complex neurometabolic cascade characterized by ionic imbalance, mitochondrial dysfunction, cerebral blood flow alterations, diffuse axonal injury, and neuroinflammation. In pediatric populations, unique neurodevelopmental vulnerabilities (higher head-to-torso ratio, weaker cervical musculature, ongoing myelination) magnify these disturbances. Contemporary management has evolved from prolonged rest to early active recovery, incorporating brief initial rest (24-48 h) followed by sub-symptom threshold aerobic exercise, structured return-to-learn accommodations, and stepped return-to-sport protocols. Emerging diagnostic tools include the Child SCAT6/Child SCOAT6, vestibular/ocular motor screening, and blood biomarkers (GFAP, UCH-L1, NfL). Future research should focus on standardizing pediatric biomarker thresholds and validating multimodal diagnostic algorithms through prospective multicenter studies. FAU - Raicevic, Mirjana AU - Raicevic M AD - Department of Neurosurgery, University Children's Hospital, Tirsova St. 10, 11000 Belgrade, Serbia. FAU - Nikolovski, Srdjan S AU - Nikolovski SS AUID- ORCID: 0000-0002-3142-2199 AD - Department of Neurosurgery, University Children's Hospital, Tirsova St. 10, 11000 Belgrade, Serbia. AD - Faculty of Medicine, University of Belgrade, Dr. Subotica St. 8, 11000 Belgrade, Serbia. AD - Department of Pathology and Laboratory Medicine, Loyola University Chicago Medical Center, 2160 S First Ave, Maywood, IL 60153, USA. AD - Serbian Resuscitation Council, Dr. Djordja Joanovica St. 2, 21000 Novi Sad, Serbia. AD - Faculty of Pharmacy Belgrade, University Educons, Poenkareova St. 14, 11000 Belgrade, Serbia. LA - eng PT - Journal Article PT - Review DEP - 20260921 PL - Switzerland TA - Brain Sci JT - Brain sciences JID - 101598646 PMC - PMC13604428 OTO - NOTNLM OT - Child SCOAT6 OT - blood biomarkers OT - mild traumatic brain injury OT - neurometabolic cascade OT - pediatric concussion OT - return-to-learn OT - return-to-sport OT - sub-threshold exercise COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/21 CRDT- 2026/09/26 01:03 PHST- 2026/07/28 00:00 [received] PHST- 2026/09/15 00:00 [revised] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:03 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - brainsci16090998 [pii] AID - brainsci-16-00998 [pii] AID - 10.3390/brainsci16090998 [doi] PST - epublish SO - Brain Sci. 2026 Sep 21;16(9):998. doi: 10.3390/brainsci16090998. PMID- 42792932 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20261001 IS - 2073-4425 (Electronic) IS - 2073-4425 (Linking) VI - 17 IP - 9 DP - 2026 Aug 29 TI - Illustrative Variant-Positive Molecular Autopsy Series: Autopsy-Led Concordance of Loeys-Dietz Spectrum Findings in Eight Florida Sudden Deaths. LID - 10.3390/genes17091040 [doi] LID - 1040 AB - Background/Objectives: Molecular autopsy increasingly identifies rare variants in heritable aortopathy and Loeys-Dietz spectrum genes among sudden-death decedents, yet classification and causal attribution remain challenging when a syndromic diagnosis was never established during life. We reviewed eight unrelated Florida medical examiner decedents ascertained by sudden or unexpected death under medical examiner jurisdiction, including laboratory-reported heterozygous missense variants spanning the Loeys-Dietz syndrome (LDS)/familial thoracic aortic aneurysm and dissection (FTAAD) gene spectrum (TGFBR1, TGFBR2, TGFB2, and SMAD3). None had a premortem clinical diagnosis of LDS; ascertainment was therefore a variant-positive molecular autopsy series, not clinically diagnosed LDS. This illustrative series of eight cases cannot estimate prevalence, diagnostic yield, penetrance, or incidental-finding frequency. Methods: Autopsy (+/-premortem) phenotype-variant concordance was graded as strong, limited, discordant, or not assessable without treating death as evidence of pathogenicity or equating laboratory detection with clinical LDS diagnosis. Grades were assigned by the authors using predefined rules, were not blinded to laboratory class, and were reconciled by consensus discussion; inter-rater reliability was not quantified. Population, computational, and ClinVar annotations, together with multi-axis molecular triangulation, were retained as supplementary context only. Results: Laboratory classifications were pathogenic in one case (TGFBR1 p.Arg487Gln, Case 1), likely pathogenic in another (TGFBR2 p.Glu428Asp, Case 3), and variants of uncertain significance (VUS) in the remaining cases. Strong phenotype-variant concordance mapped to two aortic-catastrophe decedents (Cases 1 and 3), limited concordance to two cases (Cases 4 and 5), and discordant presentations to four (Cases 2, 6, 7, and 8), including pulmonary thromboembolism without aortopathy, infant sudden death with competing cardiomyopathy-gene context, and ethanol-related death with a normal aorta (SMAD3 Case 8). Conclusions: In this illustrative variant-positive series, 2/8 cases had strong autopsy-led concordance, 2/8 limited, and 4/8 discordant. Autopsy-led concordance grading distinguished two LDS-spectrum variants with strong phenotype-variant concordance for fatal ascending aortic catastrophe from six variants with limited or discordant support. Rare variants in TGFBR1, TGFBR2, TGFB2, or SMAD3 should not be conflated with an LDS diagnosis or with the cause of death without concordant autopsy evidence. FAU - Fernandez-Cadena, Juan AU - Fernandez-Cadena J AUID- ORCID: 0000-0002-0398-8371 AD - Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. AD - Omics Science Laboratory, Faculty of Health Science, Universidad Espiritu Santo, Samborondon 092301, Ecuador. FAU - Naylor, Edwin W AU - Naylor EW AD - NCGM Laboratory, Apex, NC 27502, USA. FAU - Bhattacharjee, Arindam AU - Bhattacharjee A AD - Department of Pediatrics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. LA - eng GR - Harriet Joyce Foundation/ PT - Journal Article DEP - 20260829 PL - Switzerland TA - Genes (Basel) JT - Genes JID - 101551097 RN - EC 2.7.11.30 (Receptor, Transforming Growth Factor-beta Type I) RN - EC 2.7.11.30 (Receptor, Transforming Growth Factor-beta Type II) RN - 0 (Smad3 Protein) RN - 0 (SMAD3 protein, human) RN - 0 (TGFB2 protein, human) RN - EC 2.7.11.30 (TGFBR1 protein, human) RN - EC 2.7.11.30 (TGFBR2 protein, human) RN - 0 (Transforming Growth Factor beta2) SB - IM MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Autopsy MH - *Death, Sudden/pathology MH - Florida/epidemiology MH - *Loeys-Dietz Syndrome/genetics/pathology/diagnosis MH - Phenotype MH - Receptor, Transforming Growth Factor-beta Type I/genetics MH - Receptor, Transforming Growth Factor-beta Type II/genetics MH - Smad3 Protein/genetics MH - Transforming Growth Factor beta2 PMC - PMC13606872 OTO - NOTNLM OT - Loeys-Dietz syndrome OT - SMAD3 OT - TGFB2 OT - TGFBR1 OT - TGFBR2 OT - aortic dissection OT - molecular autopsy OT - sudden death OT - variant of uncertain significance COIS- Co-author Ed Naylor was an employee of NCGM. All other authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/08/29 CRDT- 2026/09/26 01:02 PHST- 2026/07/31 00:00 [received] PHST- 2026/08/26 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:02 [entrez] PHST- 2026/08/29 00:00 [pmc-release] AID - genes17091040 [pii] AID - genes-17-01040 [pii] AID - 10.3390/genes17091040 [doi] PST - epublish SO - Genes (Basel). 2026 Aug 29;17(9):1040. doi: 10.3390/genes17091040. PMID- 42792471 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260926 LR - 20260929 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 9 DP - 2026 Sep 17 TI - Psychometric Properties of the French Version of the Physical Literacy Self-Description (PLSD) Questionnaire Among Children. LID - 10.3390/bs16091672 [doi] LID - 1672 AB - This study sought to document the psychometric properties of scores on the French Version of the Physical Literacy Self-Description questionnaire. A sample of 191 French-speaking Canadian and French children, aged 5-12 years, participated in this study. Results from an exploratory factor analytic solution supported a two-factor solution encompassing (a) perceived confidence and value; and (b) perceived skills competence. Subsequent analyses supported the weak, strong and strict invariance of this solution as a function of sex, and its weak, strong, and partial strict invariance (one item was less reliable in France) across countries. The results also revealed meaningful differences in terms of latent variances (showing more inter-individual variability in Canada and among boys) and covariances (showing stronger correlations in France and among boys) across grouping variables. Results further revealed a lack of differential item functioning as a function of age and time spent in moderate to vigorous physical activities, but minimal evidence of differential item functioning as a function of body mass index (on two items). Moreover, Canadian children scored higher on perceived confidence and value and lower on perceived skills competence, while younger children scored higher on perceived skills competence. Likewise, children spending more time in moderate physical activity scored higher in the perceived confidence and value factor, while those spending more time in vigorous physical activity scored higher on the perceived skills competence factor. Finally, results supported the convergent validity of scores obtained on the French Physical Literacy Self-Description questionnaire in relation to parental ratings of children's overall, cognitive, and motor physical literacy. FAU - Maiano, Christophe AU - Maiano C AUID- ORCID: 0000-0002-4764-2209 AD - Department of Psychoeducation and Psychology, Universite du Quebec en Outaouais, Saint-Jerome, QC J7Z 0B7, Canada. AD - Cyberpsychology Laboratory, Department of Psychoeducation and Psychology, Universite du Quebec en Outaouais, Gatineau, QC J8X 3X7, Canada. AD - Substantive-Methodological Synergy Research Laboratory, Department of Psychology, Concordia University, Montreal, QC H4B 1R6, Canada. FAU - Morin, Alexandre J S AU - Morin AJS AUID- ORCID: 0000-0001-6898-4788 AD - Substantive-Methodological Synergy Research Laboratory, Department of Psychology, Concordia University, Montreal, QC H4B 1R6, Canada. AD - Optentia Research Unit, North-West University, P.O. Box 1174, Vanderbijlpark 1900, South Africa. FAU - April, Johanne AU - April J AD - Department of Educational Sciences, Universite du Quebec en Outaouais, Saint-Jerome, QC J7Z 0B7, Canada. FAU - Hue, Olivier AU - Hue O AUID- ORCID: 0000-0001-9270-5291 AD - Department of Physical Activity Sciences, Universite du Quebec a Trois-Rivieres, Trois-Rivieres, QC G9A 5H7, Canada. FAU - Rey, Olivier AU - Rey O AD - ISM, CNRS, Aix Marseille University, 13288 Marseille Cedex 09, France. LA - eng GR - 633-2022-00060/Social Sciences and Humanities Research Council/ PT - Journal Article DEP - 20260917 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13603781 OTO - NOTNLM OT - French OT - cross-sectional validation study OT - differential item functioning OT - exploratory factor analyses OT - measurement invariance OT - physical activity OT - physical literacy COIS- The authors declare no conflicts of interest. EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/17 CRDT- 2026/09/26 01:01 PHST- 2026/06/29 00:00 [received] PHST- 2026/09/07 00:00 [revised] PHST- 2026/09/10 00:00 [accepted] PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 01:01 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - bs16091672 [pii] AID - behavsci-16-01672 [pii] AID - 10.3390/bs16091672 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Sep 17;16(9):1672. doi: 10.3390/bs16091672. PMID- 42791621 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260930 IS - 1365-2060 (Electronic) IS - 0785-3890 (Print) IS - 0785-3890 (Linking) VI - 58 IP - 1 DP - 2026 Dec TI - Improving early risk stratification for bronchopulmonary Dysplasia in preterm infants using machine learning: development and external validation. PG - 2739022 LID - 10.1080/07853890.2026.2739022 [doi] LID - 2739022 AB - BACKGROUND: Despite advances in perinatal care and improved survival of preterm infants, bronchopulmonary dysplasia (BPD) remains a major neonatal morbidity with long-term consequences. Accurate early risk prediction is therefore clinically important. Conventional models may be limited in capturing the complex and nonlinear interactions underlying BPD, whereas machine learning offers greater flexibility for high-dimensional clinical data. However, limited interpretability remains a barrier to clinical implementation. METHOD: This retrospective study included 1,083 preterm infants with gestational age <32 weeks and birth weight <2,500 g admitted to the Affiliated Women's Hospital of Jiangnan University from January 2011 to December 2025. Data were split 7:3 into training and validation sets. Seven models were evaluated, with hyperparameters optimized by 10-fold cross-validation using AUC. Missing data were handled by complete case analysis. Performance was assessed using AUC-ROC, Brier score, and decision curve analysis (DCA), while SHAP and partial dependence plots (PDP) were used for interpretation. The optimal model was externally validated in an independent cohort of 1,000 neonates. RESULT: GBM showed the best internal performance, with an AUC of 0.880, accuracy of 0.793, sensitivity of 0.827, specificity of 0.759, and Brier score of 0.141. Birth weight, gestational age, and 1-minute Apgar score were the leading predictors. Neonatal anemia was strongly associated with BPD (aOR = 5.036, 95% CI: 3.35-7.57). PDP demonstrated a nonlinear association between birth weight and BPD risk, with a sharp increase between 1,250 and 1,500 g. DCA indicated favorable net clinical benefit across relevant threshold probabilities. CONCLUSION: The GBM model provides interpretable, individualized early BPD risk estimates using routinely available clinical variables and may support identification of high-risk preterm infants. It is intended for risk stratification rather than treatment guidance. Prospective multicenter validation is required before routine clinical implementation. FAU - Xu, Yequan AU - Xu Y AD - Department of Neonatology, Affiliated Women's Hospital of Jiangnan University, Wuxi, China. FAU - Zhang, Ying AU - Zhang Y AD - Department of Pediatrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. FAU - Ye, Danni AU - Ye D AD - Department of Neonatology, Affiliated Women's Hospital of Jiangnan University, Wuxi, China. FAU - Jiang, Shanyu AU - Jiang S AD - Department of Neonatology, Affiliated Women's Hospital of Jiangnan University, Wuxi, China. FAU - Yu, Renqiang AU - Yu R AD - Department of Neonatology, Affiliated Women's Hospital of Jiangnan University, Wuxi, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260925 PL - England TA - Ann Med JT - Annals of medicine JID - 8906388 SB - IM MH - Humans MH - *Bronchopulmonary Dysplasia/diagnosis/epidemiology MH - Infant, Newborn MH - Retrospective Studies MH - Risk Assessment/methods MH - Female MH - Infant, Premature MH - Gestational Age MH - *Machine Learning MH - Male MH - Predictive Learning Models MH - Prediction Algorithms MH - ROC Curve MH - Area Under Curve MH - Birth Weight MH - Boosting Machine Learning Algorithms MH - Risk Factors PMC - PMC13618190 OAB - A gradient boosting machine (GBM) model incorporating routinely available clinical variables achieved high predictive accuracy (AUC 0.880) for early risk stratification of bronchopulmonary dysplasia in preterm infants and demonstrated strong discriminative performance in external validation.Gestational age, birth weight, and 1-minute Apgar score were the strongest predictors of BPD, with neonatal anemia emerging as a major independent risk factor (aOR 5.036, 95% CI: 3.35-7.57).The model provides interpretable, individualized risk estimates with favorable clinical utility across a range of threshold probabilities, offering a practical tool to support early risk stratification decisions in the neonatal intensive care unit. OABL- eng OTO - NOTNLM OT - Bronchopulmonary dysplasia OT - clinical prediction model OT - gradient boosting machine OT - interpretability OT - machine learning OT - very low birth weight COIS- No potential conflict of interest was reported by the author(s). EDAT- 2026/09/26 05:35 MHDA- 2026/09/26 05:36 PMCR- 2026/09/25 CRDT- 2026/09/26 00:32 PHST- 2026/09/26 05:36 [medline] PHST- 2026/09/26 05:35 [pubmed] PHST- 2026/09/26 00:32 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - 2739022 [pii] AID - 10.1080/07853890.2026.2739022 [doi] PST - ppublish SO - Ann Med. 2026 Dec;58(1):2739022. doi: 10.1080/07853890.2026.2739022. Epub 2026 Sep 25. PMID- 42791031 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260929 IS - 1746-1561 (Electronic) IS - 0022-4391 (Linking) VI - 96 IP - 10 DP - 2026 Oct TI - Estimating VO(2)max With the Timed Mile Run: An Updated Equation for Today's Youth. PG - e70246 LID - 10.1111/josh.70246 [doi] AB - BACKGROUND: School-based physical fitness testing (SB-PFT) is an important tool to address youth physical inactivity. However, the widely used Fitnessgram equation that converts timed mile run performance into estimates of cardiorespiratory fitness (VO(2)max) may not be valid for today's diverse US adolescent population. This study evaluated its validity, developed updated prediction equations, and examined the effect of omitting sex and/or BMI. METHODS: A diverse sample of middle school students (n = 177) provided demographic information and timed mile run data and completed lab-based VO(2)max testing. Prediction accuracy for the Fitnessgram equation and newly-developed equations was assessed using root mean square error (RMSE), Pearson's correlation, and sensitivity and specificity. RESULTS: In this diverse sample, all four new VO(2)max prediction equations outperformed the Fitnessgram equation, including equations excluding sex and/or BMI. IMPLICATIONS FOR SCHOOL HEALTH POLICY, PRACTICE, AND EQUITY: When evaluated on a diverse sample of adolescents, the Fitnessgram misclassifies many adolescents as being in the healthy fitness zone despite having cardiorespiratory fitness levels associated with elevated health risk. CONCLUSIONS: The Fitnessgram VO(2)max prediction equation should be updated to reflect contemporary US demographics and schools' concerns about collecting BMI data. CI - (c) 2026 American School Health Association. FAU - Gao, Lynn AU - Gao L AUID- ORCID: 0000-0002-3527-5130 AD - Department of Statistics, University of California, Irvine, California, USA. FAU - Berrocal, Veronica AU - Berrocal V AUID- ORCID: 0000-0003-0304-7202 AD - Department of Statistics, University of California, Irvine, California, USA. FAU - Woodworth, Amanda AU - Woodworth A AUID- ORCID: 0000-0003-4055-4625 AD - Institute for Clinical and Translational Science, University of California, Irvine, California, USA. FAU - Thompson, Hannah R AU - Thompson HR AUID- ORCID: 0000-0003-0214-5003 AD - Nutrition Policy Institute, University of California Agriculture and Natural Resources, Berkeley, California, USA. AD - Department of Community Health Sciences, University of California, Berkeley, California, USA. FAU - Schneider, Margaret AU - Schneider M AD - Institute for Clinical and Translational Science, University of California, Irvine, California, USA. AD - Department of Population Health and Disease Prevention, University of California, Irvine, California, USA. LA - eng PT - Journal Article PL - United States TA - J Sch Health JT - The Journal of school health JID - 0376370 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Oxygen Consumption/physiology MH - *Exercise Test/methods MH - *Cardiorespiratory Fitness/physiology MH - Body Mass Index MH - Male MH - *Running/physiology MH - *Physical Fitness/physiology MH - Child OTO - NOTNLM OT - BMI OT - VO2max prediction equation OT - representative sample OT - school-based physical fitness testing EDAT- 2026/09/25 23:47 MHDA- 2026/09/25 23:48 CRDT- 2026/09/25 21:22 PHST- 2026/08/12 00:00 [revised] PHST- 2026/03/05 00:00 [received] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/09/25 23:48 [medline] PHST- 2026/09/25 23:47 [pubmed] PHST- 2026/09/25 21:22 [entrez] AID - 10.1111/josh.70246 [doi] PST - ppublish SO - J Sch Health. 2026 Oct;96(10):e70246. doi: 10.1111/josh.70246. PMID- 42790906 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20261003 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 9 DP - 2026 Sep 25 TI - Adaptation and evaluation of a food preference assessment tool for older adults in geriatric care: the DYSPHAGING Preferences study protocol. PG - e120395 LID - 10.1136/bmjopen-2026-120395 [doi] LID - e120395 AB - INTRODUCTION: Undernutrition is a major concern in older adults due to its multifactorial origins and its impact on morbidity and mortality. Oropharyngeal dysphagia is common in frail geriatric patients and contributes to undernutrition by prompting individuals to progressively withdraw foods from their diet, leading to dietary imbalance and potential complications. Although texture adaptation and nutritional strategies are widely implemented in clinical practice, little is known about the actual food preferences of hospitalised older adults with dysphagia. Existing tools to assess food preferences are scarce and poorly adapted to the heterogeneity and sensory impairments of this population. The DYSPHAGING Preferences study aims to develop a food-preference assessment tool specifically tailored to hospitalised older adults, assess its test-retest reliability and describe food preferences measured using this adapted instrument. METHODS AND ANALYSIS: The DYSPHAGING Preferences study is designed as a prospective, multicentre, non-comparative protocol consisting of three steps. Step 1 will adapt a forced-choice questionnaire-initially developed for paediatric populations-to adults aged>/=70 years hospitalised in geriatric wards, by assessing visual and lexical recognition of pre-selected food items. Step 2 will evaluate the test-retest reliability and practical feasibility of administering the preference questionnaire in a new cohort of older adults. Step 3 will be a cross-sectional study describing food preferences and comparing Preference Indexes between participants screening positive and screening negative for dysphagia using the Eating Assessment Tool-10. The questionnaire will include six categories of food (acidic, textured, sweet, in sauce, dairy and cooked). A total of 209 participants will be included across acute geriatric, rehabilitation and long-term care units (35 participants in step 1, 35 participants in step 2 and 174 participants in step 3, with the 35 participants from step 2 included in the step 3 population). Descriptive and comparative analyses will be performed according to a predefined statistical analysis plan. ETHICS AND DISSEMINATION: The study protocol was approved by the Comite de Protection des Personnes (CPP) Ile-de-France III on 11 September 2025 (approval number: 25.02467.000911-2025-A00795-44), in accordance with French legislation. All participants will provide informed non-opposition in accordance with national regulations. The results of the primary and secondary objectives will be disseminated through peer-reviewed publications, conference presentations and communication with clinical stakeholders. TRIAL REGISTRATION NUMBER: NCT05734586. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Masse-Deragon, Nicolas AU - Masse-Deragon N AD - Institut du Vieillissement, Hospices Civils de Lyon, Lyon, France nicolas.masse-deragon@chu-lyon.fr. FAU - Tripoz-Dit-Masson, Stephanie AU - Tripoz-Dit-Masson S AD - CRC Vieillissement Cerveau Fragilite, Hospices Civils de Lyon, Lyon, France. FAU - Grehalle, Coline AU - Grehalle C AD - Speech therapist team - Centre Hospitalier de Pierre Garraud, Hospices Civils de Lyon, Lyon, France. FAU - Subtil, Fabien AU - Subtil F AD - Service de Biostatistique, Hospices Civils de Lyon, Lyon, Auvergne-Rhone-Alpes, France. AD - CNRS, UMR5558, Laboratoire de Biometrie et Biologie Evolutive, Universite Claude Bernard Lyon 1, Villeurbanne, France. FAU - Rouze, Heloise AU - Rouze H AD - Pole de Sante Publique, Hospices Civils de Lyon, Lyon, France. AD - Laboratoire Reshape, Universite Claude Bernard Lyon 1, Lyon, France. FAU - Grilot, Cecile AU - Grilot C AD - Dietitian team - Centre Hospitalier Pierre Garraud, Hospices Civils de Lyon, Lyon, France. FAU - Merazga, Salima AU - Merazga S AD - Direction a la Recherche en Sante, Hospices Civils de Lyon, Lyon, France. FAU - Goldet, Karine AU - Goldet K AD - Centre de Recherche Clinique Vieillissement Cerveau Fragilite - Hopital des Charpennes, Hospices Civils de Lyon, Villeurbanne, France. FAU - Durlach, Olivier AU - Durlach O AD - Institut du Vieillissement, Hospices Civils de Lyon, Lyon, France. FAU - Schir, Sophie AU - Schir S AD - Institut du Vieillissement, Hospices Civils de Lyon, Lyon, France. AD - Geriatric department - Centre Hospitalier Pierre Garraud, Hospices Civils de Lyon, Lyon, France. FAU - Haution-Bitker, Marine AU - Haution-Bitker M AD - Institut du Vieillissement, Hospices Civils de Lyon, Lyon, France. AD - Geriatric department - Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France. FAU - Merdinian, Marion AU - Merdinian M AD - Institut du Vieillissement, Hospices Civils de Lyon, Lyon, France. AD - Geriatric department - Centre Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France. FAU - Falandry, Claire AU - Falandry C AUID- ORCID: 0000-0001-7267-4723 AD - CarMeN Laboratory, Inserm U1060, INRA U1397, Universite Claude Bernard Lyon 1, INSA Lyon, Charles Merieux Medical School, University of Lyon, Oullins, France. AD - Geriatric department - Centre Hospitalier de la Croix-Rousse, Hospices Civils de Lyon, Lyon, France. LA - eng SI - ClinicalTrials.gov/NCT05734586 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260925 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Aged MH - Aged, 80 and over MH - Female MH - Humans MH - Male MH - Cross-Sectional Studies MH - *Deglutition Disorders/diagnosis/psychology MH - *Food Preferences MH - Frail Elderly MH - *Geriatric Assessment/methods MH - Prospective Studies MH - Reproducibility of Results MH - Research Design MH - Surveys and Questionnaires MH - Multicenter Studies as Topic PMC - PMC13630011 OTO - NOTNLM OT - Frail Elderly OT - GERIATRIC MEDICINE OT - NUTRITION & DIETETICS OT - Organisation of health services OT - Protocols & guidelines COIS- Competing interests: NM-D reports financial support was provided by La Societe Francophone de Nutrition Clinique et Metabolisme. CF reports a relationship with Geriamed that includes: speaking and lecture fees. EDAT- 2026/09/25 23:47 MHDA- 2026/09/25 23:48 PMCR- 2026/09/25 CRDT- 2026/09/25 20:43 PHST- 2026/09/25 23:48 [medline] PHST- 2026/09/25 23:47 [pubmed] PHST- 2026/09/25 20:43 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - bmjopen-2026-120395 [pii] AID - 10.1136/bmjopen-2026-120395 [doi] PST - epublish SO - BMJ Open. 2026 Sep 25;16(9):e120395. doi: 10.1136/bmjopen-2026-120395. PMID- 42789770 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20261009 IS - 2368-7959 (Electronic) IS - 2368-7959 (Linking) VI - 13 DP - 2026 Sep 25 TI - Perinatal Mental Health Detection and Prediction Using Mobile Sensing Data: Systematic Review. PG - e101677 LID - 10.2196/101677 [doi] LID - e101677 AB - BACKGROUND: Perinatal mental health disorders affect approximately 20% of pregnant and postpartum individuals, and are associated with substantial maternal and infant morbidity. Traditional assessment relies on infrequent, subjective self-reports. Mobile devices, including smartphones and wearables, offer opportunities for continuous and objective measurement, but evidence on their assessment utility in perinatal populations remains fragmented. OBJECTIVE: This review aimed to examine the application of wearable devices and smartphones for detecting and predicting perinatal mental health outcomes, with emphasis on predictive performance, informative features, and methodological rigor. METHODS: We conducted a systematic review following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines (PROSPERO CRD420251249218). Six databases (PubMed, Web of Science, Scopus, PsycINFO, IEEE Xplore, and ACM Digital Library) were searched initially in January 2026 and supplemented by an amended search in June 2026, with no publication date restrictions. Evidence was synthesized narratively, and the risk of bias was assessed using PROBAST+AI (Prediction Model Risk of Bias Assessment Tool With AI extension). RESULTS: The initial and supplementary searches yielded 1952 unique records after deduplication, of which 10 studies met the inclusion criteria. The included studies covered postpartum depression, prenatal stress, discrete emotions during pregnancy (eg, happiness, anxiety, and sadness), and maternal loneliness. High discrimination metrics were reported for postpartum depression in individual studies, including a multiclass area under the curve of 0.85, a binary area under the curve of 0.871, and an F(1)-score of 0.9872. Heart rate variability, GPS-derived mobility, physical activity, and sleep features were most frequently reported as useful, and their interpretation requires perinatal-specific contextualization. Methodological quality was limited, with 80% (12/15) of PROBAST+AI assessment units rated as having high overall quality concern or risk of bias, mainly due to small samples, limited validation, inadequate handling of missing data, and potential overfitting in the analysis domain. CONCLUSIONS: Mobile sensing shows preliminary potential for perinatal mental health assessment, but current evidence does not yet support clinical screening or decision-making, and independent external validation in perinatal populations is currently lacking. Progress toward clinical utility requires broader mental health outcome coverage, larger longitudinal cohorts, standardized analytical and reporting practices, adoption of modeling approaches better suited to perinatal trajectories, independent external validation, and human-centered monitoring designs. CI - (c) Yifan Sun, Kemeng Che, Tella Lantta, Anna Axelin, Iman Azimi, Pasi Liljeberg. Originally published in JMIR Mental Health (https://mental.jmir.org). FAU - Sun, Yifan AU - Sun Y AUID- ORCID: 0009-0009-1897-0308 AD - Department of Computing, University of Turku, Yliopistonmaki, Turku, Southwest Finland, FI-20014, Finland, 358 0449508020. FAU - Che, Kemeng AU - Che K AUID- ORCID: 0009-0002-3086-6166 AD - Department of Nursing Science, University of Turku, Turku, Southwest Finland, Finland. FAU - Lantta, Tella AU - Lantta T AUID- ORCID: 0000-0001-7715-7573 AD - Department of Nursing Science, University of Turku, Turku, Southwest Finland, Finland. FAU - Axelin, Anna AU - Axelin A AUID- ORCID: 0000-0003-2743-3589 AD - Department of Nursing Science, University of Turku, Turku, Southwest Finland, Finland. FAU - Azimi, Iman AU - Azimi I AUID- ORCID: 0000-0001-5003-299X AD - Department of Computing, University of Turku, Yliopistonmaki, Turku, Southwest Finland, FI-20014, Finland, 358 0449508020. FAU - Liljeberg, Pasi AU - Liljeberg P AUID- ORCID: 0000-0002-9392-3589 AD - Department of Computing, University of Turku, Yliopistonmaki, Turku, Southwest Finland, FI-20014, Finland, 358 0449508020. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260925 PL - Canada TA - JMIR Ment Health JT - JMIR mental health JID - 101658926 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Mental Disorders/diagnosis MH - *Pregnancy Complications/diagnosis MH - *Wearable Electronic Devices MH - Digital Health MH - *Smartphone PMC - PMC13614507 OTO - NOTNLM OT - digital phenotyping OT - machine learning OT - perinatal mental health OT - postpartum depression OT - smartphone sensing OT - systematic review OT - wearable devices COIS- Conflicts of Interest: None declared. EDAT- 2026/09/25 17:33 MHDA- 2026/09/25 17:34 PMCR- 2026/09/25 CRDT- 2026/09/25 14:53 PHST- 2026/05/18 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/25 17:34 [medline] PHST- 2026/09/25 17:33 [pubmed] PHST- 2026/09/25 14:53 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - v13i1e101677 [pii] AID - 101677 [pii] AID - 10.2196/101677 [doi] PST - epublish SO - JMIR Ment Health. 2026 Sep 25;13:e101677. doi: 10.2196/101677. PMID- 42789372 OWN - NLM STAT- Publisher LR - 20260925 IS - 1746-1553 (Electronic) IS - 0309-3646 (Linking) DP - 2026 Aug 10 TI - Machine learning-based prediction model for initial correction effect of Cheneau brace in adolescent idiopathic scoliosis. LID - 10.1097/PXR.0000000000000582 [doi] AB - BACKGROUND: Predicting the initial correction rate (ICR) of Cheneau brace treatment for adolescent idiopathic scoliosis (AIS) is critical for personalized therapeutic planning but remains underexplored. This study aims to develop a clinical prediction model for ICR evaluation. METHODS: A retrospective analysis included 391 spinal curves from 310 patients with AIS (since some patients have double curves) from 4 orthotic centers. Key variables encompassed demographics, axial trunk rotation (ATR), Risser sign, curve type (C-shaped/S-shaped), apical location (thoracic/lumbar), and prebrace Cobb angle. ICR was calculated as [(prebrace Cobb - postbrace Cobb)/prebrace Cobb] x 100%, with satisfactory correction defined as ICR >/=50%. Logistic regression and random forest models were trained (70% data) and validated (30%). Feature importance was assessed through mean decrease accuracy (MDA) and Gini (MDG). A nomogram integrated significant predictors. RESULTS: Multivariate analysis identified Risser sign (OR = 0.033, P < 0.001), ATR (OR = 0.853, P < 0.001), curve type (OR = 0.485, P = 0.036), apical location (OR = 5.827, P < 0.001), and BMI (OR = 0.897, P = 0.041) as independent predictors. Random forest confirmed Risser sign as the most influential variable (MDA = 28.07%, MDG = 24.35%), followed by ATR (MDA = 21.99%, MDG = 19.50%). Both models demonstrated high predictive accuracy: logistic regression (AUC = 0.951, accuracy = 0.879) and random forest (AUC = 0.959, accuracy = 0.897). Lumbar curves and C-shaped curves exhibited superior correctability. CONCLUSION: Machine learning models effectively predict Cheneau brace ICR, with Risser sign and ATR angle as primary determinants. The developed nomogram provides a practical tool for pretreatment outcome anticipation, enhancing clinical decision-making in AIS management. CI - Copyright (c) 2026 The Authors. Published by Wolters Kluwer incorporated on behalf of The International Society for Prosthetics and Orthotics. FAU - Li, Kai-Hua AU - Li KH AUID- ORCID: 0000-0001-7543-2324 AD - Institute of Orthopedics, Fengfeng General Hospital of North China Medical & Health Group, Handan, Hebei, China. AD - North China University of Science and Technology, Tangshan, Hebei, China. FAU - Zhang, Li-Ning AU - Zhang LN AD - Department of Medical Radiology, Fengfeng General Hospital of North China Medical & Health Group, Handan, Hebei, China. FAU - Xiong, Hui-Ling AU - Xiong HL AD - Department of Medical Radiology, Fengfeng General Hospital of North China Medical & Health Group, Handan, Hebei, China. FAU - Chen, Bao-Sheng AU - Chen BS AD - Institute of Orthopedics, Fengfeng General Hospital of North China Medical & Health Group, Handan, Hebei, China. FAU - Yi, Li-Sha AU - Yi LS AD - Institute of Nursing, Fengfeng General Hospital of North China Medical & Health Group, Handan, Hebei, China. LA - eng GR - 23422083389/Handan Science and Technology Research and Development Program Project/ PT - Journal Article DEP - 20260810 PL - France TA - Prosthet Orthot Int JT - Prosthetics and orthotics international JID - 7707720 SB - IM OTO - NOTNLM OT - Cheneau brace OT - adolescent idiopathic scoliosis OT - initial correction rate OT - machine learning OT - predictive modeling OT - risser sign EDAT- 2026/09/25 17:33 MHDA- 2026/09/25 17:33 CRDT- 2026/09/25 12:33 PHST- 2025/11/23 00:00 [received] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/09/25 17:33 [medline] PHST- 2026/09/25 17:33 [pubmed] PHST- 2026/09/25 12:33 [entrez] AID - 00006479-990000000-00460 [pii] AID - 10.1097/PXR.0000000000000582 [doi] PST - aheadofprint SO - Prosthet Orthot Int. 2026 Aug 10. doi: 10.1097/PXR.0000000000000582. PMID- 42788574 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260929 IS - 1984-0462 (Electronic) IS - 0103-0582 (Print) IS - 0103-0582 (Linking) VI - 44 DP - 2026 TI - Factors associated with musculoskeletal pain in the spinal column of children and adolescents: a cross-sectional study with network analysis. PG - e2026040 LID - S0103-05822026000101028 [pii] LID - 10.1590/1984-0462/2026/44/2026040 [doi] LID - e2026040 AB - OBJECTIVE: The aim of this study was to analyze the relationship between musculoskeletal spinal pain and individual, behavioral, and contextual factors in children and adolescents. METHODS: A cross-sectional study was conducted with 189 children and adolescents (10-16 years), of both genders, enrolled in public and private schools in Belem, Para, Brazil. Musculoskeletal pain and postural habits were assessed using the Back Pain and Posture Evaluation Instrument for Children and Adolescents, a validated questionnaire for this population. Network analysis using the EBICglasso estimator explored associations between individual (age, gender), behavioral (physical activity in school and leisure contexts), and contextual factors (school type and postural habits related to daily activities and electronic device use) and the presence of neck and low back pain. RESULTS: The prevalence of low back pain was 62.6% and neck pain 65.4%. Low back pain was negatively associated with family history of pain (r=-0.14) and positively associated with female gender (r=0.19) and neck pain (r=0.12). Sitting posture during electronic device use was negatively associated with neck pain (r=-0.19). Gender and age showed higher centrality, indicating greater influence within the network, while physical activity showed a negative influence on pain outcomes. CONCLUSIONS: Musculoskeletal spinal pain was highly prevalent and associated with multiple interrelated factors. Network analysis highlights its multifactorial nature and provides relevant insights into key variables that may guide integrated health promotion and early prevention strategies in pediatric populations. FAU - Gomes, Marcella Veronnica Pereira AU - Gomes MVP AUID- ORCID: 0000-0002-2137-9246 AD - Universidade Federal do Para, Belem, PA, Brazil. FAU - Belem, Ruth Stefany Monteiro AU - Belem RSM AUID- ORCID: 0009-0004-6056-7364 AD - Universidade Federal do Para, Belem, PA, Brazil. FAU - Pantoja, Amanda Vitoria Gomes AU - Pantoja AVG AUID- ORCID: 0009-0009-4507-7670 AD - Universidade Federal do Para, Belem, PA, Brazil. FAU - Costa, Beatriz Dos Santos AU - Costa BDS AUID- ORCID: 0000-0002-5110-4884 AD - Universidade Federal do Para, Belem, PA, Brazil. FAU - Jardim, Naina Yuki Vieira AU - Jardim NYV AUID- ORCID: 0000-0003-3760-3684 AD - Universidade Estadual do Para, Tucurui, PA, Brazil. FAU - Crisp, Alex Harley AU - Crisp AH AUID- ORCID: 0000-0003-4683-9576 AD - Universidade Federal do Para, Belem, PA, Brazil. FAU - Magalhaes, Mauricio Oliveira AU - Magalhaes MO AUID- ORCID: 0000-0002-7857-021X AD - Universidade Federal do Para, Belem, PA, Brazil. LA - eng PT - Journal Article DEP - 20260918 PL - Brazil TA - Rev Paul Pediatr JT - Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo JID - 9109353 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Child MH - Male MH - Adolescent MH - *Musculoskeletal Pain/epidemiology/etiology MH - Prevalence MH - Brazil/epidemiology MH - *Neck Pain/epidemiology/etiology MH - Risk Factors MH - Posture MH - *Low Back Pain/epidemiology/etiology PMC - PMC13588557 EDAT- 2026/09/25 11:45 MHDA- 2026/09/25 11:46 PMCR- 2026/09/18 CRDT- 2026/09/25 10:34 PHST- 2026/02/24 00:00 [received] PHST- 2026/05/13 00:00 [accepted] PHST- 2026/09/25 11:46 [medline] PHST- 2026/09/25 11:45 [pubmed] PHST- 2026/09/25 10:34 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - S0103-05822026000101028 [pii] AID - 10.1590/1984-0462/2026/44/2026040 [doi] PST - epublish SO - Rev Paul Pediatr. 2026 Sep 18;44:e2026040. doi: 10.1590/1984-0462/2026/44/2026040. eCollection 2026. PMID- 42788340 OWN - NLM STAT- Publisher LR - 20261006 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) DP - 2026 Sep 25 TI - Urine diagnostics in paediatric intestinal failure: A prospective cohort study of alternative sampling methods. LID - 10.1002/jpn3.70597 [doi] AB - OBJECTIVES: Regular monitoring of urinary electrolyte excretion and kidney function is essential in children with intestinal failure (IF) receiving long-term parenteral nutrition (PN). This study evaluated alternative urine sampling methods against 24-h urine collection (UC) and assessed the prevalence of chronic kidney disease (CKD) and renal abnormalities. METHODS: In this prospective single-centre cohort study, 31 paediatric IF patients underwent 24-h UC, spot urine (SU) sampling, and shorter timed collections at predefined intervals. Urinary electrolytes and derived ratios were analysed. Kidney function was evaluated using cystatin C (CysC)- and creatinine (Cr)-based estimated glomerular filtration rate (eGFR) and 24-h urinary Cr clearance (CrCl). Agreement between alternative sampling methods and 24-h UC was assessed using Bland-Altman and regression analyses. Renal abnormalities were evaluated by ultrasound. RESULTS: Shorter timed UCs, particularly those corresponding to the PN infusion interval, showed the closest agreement with 24-h UC for sodium, magnesium, calcium, and phosphate excretion. Certain SU samples detected electrolyte deficiencies, particularly sodium and magnesium depletion, and low sodium-to-potassium ratios, highlighting cyclic dehydration at the end of the PN-free interval. CKD was detected in 15/30 patients (50%) by creatinine-cysC-based eGFR. Proteinuria was present in 17/29 patients (58.6%) in 24-h UC, and albuminuria in 13/26 SU samples (50%). Nephrocalcinosis was found in 37% of patients. CONCLUSIONS: Shorter timed UC and targeted SU samples may provide practical alternatives to 24-h UC for monitoring urinary electrolyte status and hydration. CKD and renal abnormalities are prevalent in children with IF receiving PN. CI - (c) 2026 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Sakaeva, Anna AU - Sakaeva A AD - Paediatric Gastroenterology and Hepatology, Department of General Paediatrics and Haematology/Oncology, University Children's Hospital Tubingen, Tubingen, Germany. FAU - Busch, Andreas AU - Busch A AD - Paediatric Gastroenterology and Hepatology, Department of General Paediatrics and Haematology/Oncology, University Children's Hospital Tubingen, Tubingen, Germany. AD - Paediatric Gastroenterology and Hepatology, Children's Hospital Princess Margaret Darmstadt, Darmstadt, Germany. FAU - Holle, Johannes AU - Holle J AUID- ORCID: 0000-0001-8032-4096 AD - Paediatric Nephrology, Department of General Paediatrics and Haematology/Oncology, University Children's Hospital Tubingen, Tubingen, Germany. FAU - Bartolomaeus, Hendrik AU - Bartolomaeus H AUID- ORCID: 0000-0003-4288-3828 AD - Institute of Experimental Biomedicine, University Hospital Wurzburg, Wurzburg, Germany. FAU - Fode, Bernd AU - Fode B AD - Department of General Paediatrics and Haematology/Oncology, University Children's Hospital Tubingen, Tubingen, Germany. FAU - Tsiflikas, Ilias AU - Tsiflikas I AUID- ORCID: 0000-0001-7166-4689 AD - Department of Diagnostic and Interventional Radiology, University Hospital Tubingen, Tubingen, Germany. FAU - Sturm, Ekkehard AU - Sturm E AUID- ORCID: 0000-0002-1489-8662 AD - Paediatric Gastroenterology and Hepatology, Department of General Paediatrics and Haematology/Oncology, University Children's Hospital Tubingen, Tubingen, Germany. FAU - Slavetinsky, Christoph AU - Slavetinsky C AUID- ORCID: 0000-0001-5576-5906 AD - Paediatric Surgery and Urology, University Children's Hospital Tubingen, Tubingen, Germany. FAU - Scherer, Simon AU - Scherer S AUID- ORCID: 0000-0002-6404-6919 AD - Paediatric Surgery and Urology, University Children's Hospital Tubingen, Tubingen, Germany. FAU - Fuchs, Jorg AU - Fuchs J AD - Paediatric Surgery and Urology, University Children's Hospital Tubingen, Tubingen, Germany. FAU - Lieber, Justus AU - Lieber J AUID- ORCID: 0000-0003-1421-0984 AD - Paediatric Surgery and Urology, University Children's Hospital Tubingen, Tubingen, Germany. FAU - Warmann, Steven W AU - Warmann SW AD - Paediatric Surgery and Urology, University Children's Hospital Tubingen, Tubingen, Germany. AD - Paediatric Surgery and Paediatric Urology, Charite University Hospital, Berlin, Germany. FAU - Hilberath, Johannes AU - Hilberath J AUID- ORCID: 0009-0005-0055-7452 AD - Paediatric Gastroenterology and Hepatology, Department of General Paediatrics and Haematology/Oncology, University Children's Hospital Tubingen, Tubingen, Germany. LA - eng GR - None/ PT - Journal Article DEP - 20260925 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM OTO - NOTNLM OT - albuminuria OT - nephrocalcinosis OT - parenteral nutrition OT - proteinuria EDAT- 2026/09/25 11:45 MHDA- 2026/09/25 11:45 CRDT- 2026/09/25 10:22 PHST- 2026/08/20 00:00 [revised] PHST- 2026/06/12 00:00 [received] PHST- 2026/09/01 00:00 [accepted] PHST- 2026/09/25 11:45 [pubmed] PHST- 2026/09/25 11:45 [medline] PHST- 2026/09/25 10:22 [entrez] AID - 10.1002/jpn3.70597 [doi] PST - aheadofprint SO - J Pediatr Gastroenterol Nutr. 2026 Sep 25. doi: 10.1002/jpn3.70597. PMID- 42788139 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260925 LR - 20260926 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 8 DP - 2026 Aug TI - Plasma Homocysteine as a Biomarker for Cardiovascular Risk Stratification in Children and Adolescents With Type 1 Diabetes Mellitus: A Cross-Sectional Study From Western Algeria. PG - e115169 LID - 10.7759/cureus.115169 [doi] LID - e115169 AB - Background Cardiovascular disease (CVD) remains the leading cause of premature morbidity and mortality among individuals living with type 1 diabetes mellitus (T1DM). Although overt cardiovascular events are uncommon during childhood, endothelial dysfunction and subclinical atherosclerosis develop early, making timely cardiovascular risk assessment essential. Plasma homocysteine has emerged as a potential biomarker of vascular injury; however, its clinical value in pediatric T1DM remains controversial, and evidence from African populations is scarce. This study aimed to evaluate plasma homocysteine concentrations in children and adolescents with T1DM and to investigate their relationship with cardiovascular risk profiles and diabetes-related complications. Methods A cross-sectional observational study was conducted at the Department of Pediatrics B, in the university hospital center of Oran, Algeria. A total of 50 children and adolescents aged 5-19 years with confirmed T1DM were included. Demographic, anthropometric, clinical, and laboratory data were retrospectively collected from medical records. Plasma total homocysteine (tHcy) concentrations, glycemic control, lipid profile, diabetes duration, insulin therapy, nephropathy, and cardiovascular risk factors were analyzed. Hyperhomocysteinemia prevalence was determined, and its association with cardiovascular risk stratification was assessed using descriptive and inferential statistical analyses. Results The study included 27 male (54%) and 23 female patients (46%), and hyperhomocysteinemia was identified in 17 of 50 participants (34%). Plasma tHcy concentrations were significantly higher in participants with HbA1c >7.5% than in those with HbA1c 7.5%; aOR = 3.26, 95% CI: 1.18-9.02; p = 0.021) and diabetes duration >/=5 years (aOR = 2.54, 95% CI: 1.01-6.42; p = 0.047) were independently associated with hyperhomocysteinemia. Plasma tHcy showed good discriminative ability for the study-specific moderate-to-high cardiovascular risk classification (AUC = 0.82, 95% CI: 0.69-0.94; p < 0.001). Conclusion Hyperhomocysteinemia was prevalent among children and adolescents with T1DM in our cohort and was associated with an unfavorable cardiovascular risk-factor profile. These findings suggest that plasma homocysteine may represent a potential investigational adjunctive marker of cardiovascular risk-factor burden in pediatric T1DM. Prospective multicenter studies are warranted to validate these associations and determine their incremental clinical value beyond established cardiovascular risk factors. CI - Copyright (c) 2026, Ameur et al. FAU - Ameur, Auda AU - Ameur A AD - Department of Pediatrics B, Amilcar Cabral, University of Oran 1 Ahmed Ben Bella, Oran, DZA. FAU - Latroch, Charef AU - Latroch C AD - Department of Pediatrics B, Amilcar Cabral, University of Oran 1 Ahmed Ben Bella, Oran, DZA. FAU - Naas, Hiba AU - Naas H AD - Laboratory of Environment, Natural Plant Substances and Food Technology, Faculty of Natural and Life Sciences, Ahmed Zabana University - Relizane, Relizane, DZA. FAU - Amraoui, Fatima AU - Amraoui F AD - Faculty of Natural and Life Sciences, Ahmed Zabana University - Relizane, Relizane, DZA. FAU - Aribi, Nacera AU - Aribi N AD - Faculty of Natural and Life Sciences, Ahmed Zabana University - Relizane, Relizane, DZA. FAU - Bouziane Nedjadi, Karim AU - Bouziane Nedjadi K AD - Department of Pediatrics B, Amilcar Cabral, University of Oran 1 Ahmed Ben Bella, Oran, DZA. LA - eng PT - Journal Article DEP - 20260825 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13608191 OTO - NOTNLM OT - algeria OT - cardiovascular disease risk factors OT - homocysteine OT - pediatric type 1 diabetes OT - vascular endothelial dysfunction COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Ethics committee of faculty of medicine of Oran issued approval dd. This study was reviewed and approved by the Ethics Committee of the Faculty of Medicine, University of Oran, Algeria (Approval No. 0082/26; July 11, 2026). The study was conducted in accordance with the ethical principles of the Declaration of Helsinki and applicable institutional guidelines for research involving human participants. (ARABIC AND FRENCH ORIGINAL DOCUMENT). Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/09/25 11:45 MHDA- 2026/09/25 11:46 PMCR- 2026/08/25 CRDT- 2026/09/25 10:03 PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/25 11:46 [medline] PHST- 2026/09/25 11:45 [pubmed] PHST- 2026/09/25 10:03 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.7759/cureus.115169 [doi] PST - epublish SO - Cureus. 2026 Aug 25;18(8):e115169. doi: 10.7759/cureus.115169. eCollection 2026 Aug. PMID- 42787313 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260925 LR - 20260926 IS - 2297-055X (Print) IS - 2297-055X (Electronic) IS - 2297-055X (Linking) VI - 13 DP - 2026 TI - Impact of anatomic complexity of congenital heart disease on growth retardation: a large retrospective cohort study. PG - 1907307 LID - 10.3389/fcvm.2026.1907307 [doi] LID - 1907307 AB - BACKGROUND: Growth retardation (GR) is a significant comorbidity in children with congenital heart disease (CHD), particularly those with complex CHD. This study aimed to characterize the growth patterns of pediatric CHD patients and to identify the factors associated with GR. METHODS: This retrospective cohort study included CHD patients aged /= 5 hospitalizations, comorbid substance use, and higher scores of emotional abuse were associated with a lower likelihood of response to lithium. DISCUSSION: Integrating the evaluation of trauma history, impulsive profiles, ruminative tendencies, and circadian features into clinical assessment may enhance the prediction of lithium response. CONCLUSION: Our findings support the development of personalized treatment strategies for BD. CI - Copyright(c) Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. FAU - Aguglia, Andrea AU - Aguglia A AUID- ORCID: 0000-0002-2003-2101 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. AD - IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy. FAU - Breda, Giulia Silvia AU - Breda GS AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. FAU - Aprile, Valentina AU - Aprile V AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. FAU - Gagliardi, Michela AU - Gagliardi M AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. FAU - Stefanini, Francesco AU - Stefanini F AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. FAU - Conio, Benedetta AU - Conio B AUID- ORCID: 0000-0002-8201-7193 AD - IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy. FAU - Costanza, Alessandra AU - Costanza A AUID- ORCID: 0000-0001-6387-6462 AD - Department of Psychiatry, Faculty of Medicine, Geneva University (UNIGE), 1205 Geneva, Switzerland. AD - Department of Psychiatry, Faculty of Biomedical Sciences, University of Italian Switzerland (USI), 6900 Lugano, Switzerland. FAU - Amore, Mario AU - Amore M AUID- ORCID: 0000-0003-2927-2192 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. FAU - Amerio, Andrea AU - Amerio A AUID- ORCID: 0000-0002-3439-340X AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. AD - IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy. FAU - Serafini, Gianluca AU - Serafini G AUID- ORCID: 0000-0002-6631-856X AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy. AD - IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy. LA - eng PT - Journal Article DEP - 20260921 PL - United Arab Emirates TA - Curr Neuropharmacol JT - Current neuropharmacology JID - 101157239 SB - IM OTO - NOTNLM OT - Bipolar disorder OT - bipolar cycle OT - chronotype OT - lithium OT - rumination OT - trauma EDAT- 2026/09/25 05:31 MHDA- 2026/09/25 05:31 CRDT- 2026/09/25 02:56 PHST- 2026/02/27 00:00 [received] PHST- 2026/06/19 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/09/25 05:31 [medline] PHST- 2026/09/25 05:31 [pubmed] PHST- 2026/09/25 02:56 [entrez] AID - CN-EPUB-158554 [pii] AID - 10.2174/011570159X482667260909062619 [doi] PST - aheadofprint SO - Curr Neuropharmacol. 2026 Sep 21. doi: 10.2174/011570159X482667260909062619. PMID- 42786460 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260926 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Sep 3 TI - Combined use of the pediatric Yorkhill malnutrition score and mid-upper arm circumference for identifying nutritional risk and predicting length of hospital stay in hospitalized children: a pilot study. LID - 10.1186/s12887-026-07609-5 [doi] LID - 905 AB - BACKGROUND: Childhood malnutrition remains a critical public health challenge among hospitalized pediatric populations, contributing to increased morbidity and prolonged length of hospital stay (LOS). In countries undergoing nutritional transition, such as Turkiye, the "double burden of malnutrition"-characterized by the coexistence of undernutrition and obesity-is exacerbated by socio-economic inequities. This study aimed to assess the prevalence and risk factors of malnutrition in hospitalized children and to evaluate the predictive validity of two rapid screening tools: the Pediatric Yorkhill Malnutrition Score (PYMS) and mid-upper arm circumference (MUAC), with attention to their utility in identifying socio-economic vulnerability. METHODS: This pilot study was conducted between January and July 2024 in a tertiary university hospital in Turkiye. A total of 100 children (50 girls, 50 boys), aged 1 month to 18 years, were evaluated. Nutritional status was assessed using World Health Organization (WHO) anthropometric Z-scores. Malnutrition risk was screened via PYMS and age-adjusted MUAC Z-scores. A novel socio-economic malnutrition risk classification was developed based on household income, family size, and maternal employment status. This pilot study tested the combined use of routine anthropometric measurements and practical screening tools such as PYMS and MUAC for a later large-scale, school-based screening. RESULTS: The double burden of malnutrition was evident: 13.0% had acute malnutrition and 11.0% chronic malnutrition (stunting); among children aged 5-18 years, 34.5% were overweight and 21.8% obese. The LOS was significantly longer in the PYMS high-risk group compared to the low-risk group (p = 0.001), and in the MUAC moderate malnutrition group (p < 0.05). PYMS demonstrated high specificity (95.89%) for acute malnutrition but limited sensitivity for stunting. Among children aged > 5 years, MUAC Z-scores correlated significantly with body mass index (BMI) Z-scores (p < 0.05). Children classified as high-risk by the socio-economic model had significantly lower height-for-age Z-scores (p < 0.05). CONCLUSIONS: This study highlights the impact of socio-economic inequities-such as low income and household overcrowding-on chronic malnutrition and confirms the clinical relevance of the double burden of malnutrition. PYMS and MUAC effectively predict prolonged hospitalization and adverse clinical outcomes. The integration of socio-economic risk assessment with routine malnutrition screening may guide equitable resource allocation and improve care for vulnerable pediatric populations. CI - (c) 2026. The Author(s). FAU - Celik, Emre AU - Celik E AD - Department of Pediatrics, Bursa City Training and Research Hospital, Bursa, Turkiye. abdullahemrecelik@gmail.com. FAU - Korkmaz, Muhammet Furkan AU - Korkmaz MF AD - Department of Pediatrics, Bursa City Training and Research Hospital, Bursa, Turkiye. FAU - Ozkaya, Yunus AU - Ozkaya Y AD - Department of Public Health, Sirnak Provincial Health Directorate, Sirnak, Turkiye. FAU - Yuce, Servet AU - Yuce S AD - Department of Public Health, Istanbul Provincial Health Directorate, Istanbul, Turkiye. FAU - Soyubelli, Tugce Dilara AU - Soyubelli TD AD - Department of Pediatrics, Bursa City Training and Research Hospital, Bursa, Turkiye. FAU - Tutanc, Murat AU - Tutanc M AD - Department of Pediatrics, Bursa City Training and Research Hospital, Bursa, Turkiye. LA - eng PT - Journal Article DEP - 20260903 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Female MH - Pilot Projects MH - Child, Preschool MH - Infant MH - Male MH - Child MH - *Length of Stay/statistics & numerical data MH - *Arm/anatomy & histology MH - Adolescent MH - Risk Factors MH - *Child Nutrition Disorders/diagnosis/epidemiology MH - Anthropometry MH - Risk Assessment/methods MH - *Nutrition Assessment MH - Child, Hospitalized MH - Prevalence MH - *Malnutrition/diagnosis/epidemiology MH - Nutritional Status MH - Predictive Value of Tests PMC - PMC13602631 OTO - NOTNLM OT - Health inequities OT - Hospitalized children OT - MUAC OT - Mid-upper arm circumference OT - Nutritional screening OT - PYMS OT - Pediatric malnutrition OT - Socio-economic determinants COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Clinical Research Ethics Committee of Bursa City Hospital (Approval No: 2023-20/3). Our study was conducted according to the Declaration of Helsinki, and Informed written and verbal consent was obtained from all participants or their legal guardians. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/25 05:32 MHDA- 2026/09/25 05:33 PMCR- 2026/09/03 CRDT- 2026/09/24 23:57 PHST- 2026/01/19 00:00 [received] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/09/25 05:33 [medline] PHST- 2026/09/25 05:32 [pubmed] PHST- 2026/09/24 23:57 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - 10.1186/s12887-026-07609-5 [pii] AID - 7609 [pii] AID - 10.1186/s12887-026-07609-5 [doi] PST - epublish SO - BMC Pediatr. 2026 Sep 3;26(1):905. doi: 10.1186/s12887-026-07609-5. PMID- 42786280 OWN - NLM STAT- Publisher LR - 20260924 IS - 1476-5454 (Electronic) IS - 0950-222X (Linking) DP - 2026 Sep 24 TI - Validation of the DIGIROP 2.0 Models in predicting the risk of treatment-requiring retinopathy of prematurity in a Taiwanese cohort. LID - 10.1038/s41433-026-04856-9 [doi] AB - BACKGROUND: To evaluate the performance of the updated DIGIROP models (version 2.0), which incorporate parenteral nutrition duration (PND; protein and lipids) data, in predicting treatment-requiring retinopathy of prematurity (ROP). METHODS: A retrospective validation study at a tertiary referral centre in Taiwan. The DIGIROP-Birth 2.0 and DIGIROP-Screen 2.0 models were applied to calculate individual risk estimates for treatment-requiring ROP. Model performance was evaluated by assessing sensitivity and specificity. Recalibration was performed based on the incidence of treatment-requiring ROP across different gestational age groups to account for differences between the study and the original developmental cohorts. The performance of the recalibrated models was then compared with that of the original DIGIROP 2.0 models. RESULTS: Among the 303 infants included, 30 required treatment for ROP. The DIGIROP-Birth 2.0 model successfully identified 28 of the treated infants (sensitivity: 93.3% [95% CI: 77.9-99.2]; specificity: 48.0% [95% CI: 41.9-54.1]). The sensitivities of DIGIROP-Screen 2.0 ranged from 93.3% (95% CI: 77.9-99.2) to 100% (95% CI: 63.1-100) during postnatal weeks 6-14. The recalibrated DIGIROP-Birth 2.0 model correctly identified all infants with treatment-requiring ROP (sensitivity: 100.0% [95% CI: 88.4-100]; specificity: 33.3% [95% CI: 27.8-39.3]), as did the recalibrated DIGIROP-Screen 2.0 model across different postnatal weeks. A model developed using gestational age and PND in our cohort yielded 100% (95% CI: 88.4-100) sensitivity and highest specificity (66.7% [95% CI: 60.7-72.2]). CONCLUSIONS: The DIGIROP 2.0 models demonstrated high sensitivities in identifying treatment-requiring ROP in this external validation cohort, particularly after recalibration, underscoring the importance of validation and modification when applying the models to different populations. Further large-scale studies are required to confirm the value of including PND in ROP screening models. CI - (c) 2026. The Author(s), under exclusive licence to The Royal College of Ophthalmologists. FAU - Huang, Ching-Wen AU - Huang CW AD - Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan, ROC. AD - Department of Ophthalmology, Fu Jen Catholic University Hospital, New Taipei City, Taiwan, ROC. FAU - Pivodic, Aldina AU - Pivodic A AD - Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Tsao, Po-Nien AU - Tsao PN AD - Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, ROC. AD - Research Center for Developmental Biology & Regenerative Medicine, National Taiwan University, Taipei, Taiwan, ROC. FAU - Hellstrom, Ann AU - Hellstrom A AUID- ORCID: 0000-0002-9259-1244 AD - Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Yeh, Po-Ting AU - Yeh PT AD - Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan, ROC. FAU - Chou, Hung-Chieh AU - Chou HC AD - Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, ROC. FAU - Chen, Chien-Yi AU - Chen CY AD - Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, ROC. FAU - Yen, Ting-An AU - Yen TA AD - Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, ROC. FAU - Huang, Hsin-Chung AU - Huang HC AD - Department of Pediatrics, National Taiwan University Hospital, Taipei, Taiwan, ROC. FAU - Lai, Tso-Ting AU - Lai TT AUID- ORCID: 0000-0002-8247-7018 AD - Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan, ROC. b91401005@ntu.edu.tw. AD - Graduate Institute of Clinical Medicine, College of Medicine, National Taiwan University, Taipei, Taiwan, ROC. b91401005@ntu.edu.tw. LA - eng PT - Journal Article DEP - 20260924 PL - England TA - Eye (Lond) JT - Eye (London, England) JID - 8703986 SB - IM COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/09/25 05:32 MHDA- 2026/09/25 05:32 CRDT- 2026/09/24 23:43 PHST- 2026/02/22 00:00 [received] PHST- 2026/09/02 00:00 [accepted] PHST- 2026/07/29 00:00 [revised] PHST- 2026/09/25 05:32 [medline] PHST- 2026/09/25 05:32 [pubmed] PHST- 2026/09/24 23:43 [entrez] AID - 10.1038/s41433-026-04856-9 [pii] AID - 10.1038/s41433-026-04856-9 [doi] PST - aheadofprint SO - Eye (Lond). 2026 Sep 24. doi: 10.1038/s41433-026-04856-9. PMID- 42785732 OWN - NLM STAT- Publisher LR - 20260924 IS - 1461-7021 (Electronic) IS - 1359-1045 (Linking) DP - 2026 Sep 24 TI - Adolescents in the Digital Age: Phubbing, Parental Phubbing, Emotional Eating, and Emotion Regulation Difficulties. PG - 13591045261491778 LID - 10.1177/13591045261491778 [doi] AB - BackgroundParental smartphone use during parent-child interactions, known as parental phubbing, may negatively affect adolescents' emotional well-being and contribute to psychological maltreatment. However, the mechanisms linking parental phubbing to adolescents' own digital behaviors remain unclear.ObjectiveThis study examined the associations among parental phubbing, adolescent phubbing, emotion regulation difficulties, perceived psychological maltreatment, and emotional eating, and investigated the mediating roles of emotion regulation difficulties and psychological maltreatment.MethodsThe sample included 128 adolescents aged 12-17 years (51.6% female) and their parents. Participants completed validated self-report measures assessing phubbing behaviors, emotion regulation difficulties, psychological maltreatment, and emotional eating. Correlation, multiple regression, and mediation analyses were conducted.ResultsAdolescent phubbing was positively associated with maternal and paternal phubbing, emotion regulation difficulties, paternal psychological maltreatment, and emotional eating (all p < .05). Regression analyses showed that paternal phubbing, emotion regulation difficulties, paternal psychological maltreatment, and gender significantly predicted adolescent phubbing, explaining 40% of the variance. Mediation analyses indicated that emotion regulation difficulties mediated the associations between both maternal and paternal phubbing and adolescent phubbing. Paternal psychological maltreatment also partially mediated the relationship between paternal phubbing and adolescent phubbing.ConclusionsParental phubbing, particularly paternal phubbing, may influence adolescents' digital behaviors through emotion regulation difficulties and perceived psychological maltreatment, highlighting the importance of parental digital habits for adolescent well-being. FAU - Avunduk, Serdar AU - Avunduk S AUID- ORCID: 0000-0003-3337-1927 AD - Department of Child and Adolescent Psychiatry Canakkale Mehmet Akif Ersoy State Hospital, Canakkale, Turkey. FAU - Aksoy Avunduk, Sena AU - Aksoy Avunduk S AUID- ORCID: 0000-0002-3909-5188 AD - Faculty of Medicine, Department of Child and Adolescent Psychiatry, Canakkale Onsekiz Mart University, Canakkale, Turkey. RINGGOLD: 52950 FAU - Gavcar, Erdal Gorkem AU - Gavcar EG AD - Faculty of Medicine, Department of Child and Adolescent Psychiatry, Pamukkale University, Denizli, Turkey. RINGGOLD: 52990 LA - eng PT - Journal Article DEP - 20260924 PL - England TA - Clin Child Psychol Psychiatry JT - Clinical child psychology and psychiatry JID - 9604507 SB - IM OAB - What is this study about? In today's digital era, parents often use their smartphones during moments spent with their children-a behavior known as "parental phubbing." This study explored how parents' phone use affects teenagers' own smartphone habits, their ability to manage negative emotions, their perceptions of emotional neglect within the family, and their tendency to engage in emotional eating. What did the researchers do? The researchers surveyed 128 adolescents aged 12 to 17 and their parents at an outpatient clinic. Participants completed questionnaires assessing parental and adolescent smartphone habits, emotion regulation difficulties, feelings of psychological maltreatment, and emotional eating behaviors. What were the key findings? Parental Influence: Teenagers were more likely to phub others if their mothers and fathers frequently used smartphones around them. The Role of Fathers: Father phubbing emerged as a particularly strong factor. Fathers' device distraction directly predicted higher adolescent phubbing and indirect risks linked to emotional dysregulation and perceived paternal emotional neglect. Emotional Dysregulation: Adolescents who struggled to process negative feelings were significantly more likely to use smartphones as an escape and turn to food to cope with distress. Why do these findings matter? This research highlights that parental digital distraction is not just a mild annoyance; it can function as a form of relational distance that undermines an adolescent's emotional well-being. Interventions should encourage device-free family times and help parents-especially fathers-understand the crucial role emotional availability plays in fostering healthy digital and lifestyle habits in youth. OABL- eng OTO - NOTNLM OT - adolescents OT - emotion regulation OT - emotional eating OT - parental phubbing OT - phubbing OT - psychological maltreatment EDAT- 2026/09/24 23:52 MHDA- 2026/09/24 23:52 CRDT- 2026/09/24 19:53 PHST- 2026/09/24 23:52 [medline] PHST- 2026/09/24 23:52 [pubmed] PHST- 2026/09/24 19:53 [entrez] AID - 10.1177/13591045261491778 [doi] PST - aheadofprint SO - Clin Child Psychol Psychiatry. 2026 Sep 24:13591045261491778. doi: 10.1177/13591045261491778. PMID- 42785553 OWN - NLM STAT- Publisher LR - 20261007 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 76 DP - 2026 Sep 24 TI - Feeding challenges in pediatric intestinal failure: Insights from three different instruments. PG - 105137 LID - S2405-4577(26)02234-5 [pii] LID - 10.1016/j.clnesp.2026.105137 [doi] AB - BACKGROUND & AIMS: Feeding difficulties are frequently reported in children with intestinal failure (IF) and may represent an important barrier to transition from parenteral nutrition (PN) to enteral autonomy. Appropriate assessment tools are essential for accurate recognition and management of feeding challenges. The objective was to evaluate feeding difficulties using three complementary assessment instruments in children with IF receiving prolonged PN. METHODS: This cross-sectional study included children aged 6 months to 18 years with IF receiving PN for more than two months. Children with oropharyngeal dysphagia, severe neurological disease and severe congenital disorders were excluded. Caregivers completed a structured interview, and three instruments were applied: American Speech-Language-Hearing Association National Outcomes Measurement System (ASHA-NOMS), Montreal Children's Hospital Feeding Scale (MCH-FS), and Schedule for Oral Motor Assessment (SOMA). Cutoff points were defined according to instrument psychometric properties. Results were analyzed by age groups. RESULTS: Fifty-one patients were evaluated (median age 31.8 months, IQR 16.1-58.2; 62.7% male). Feeding abnormalities identified by at least one instrument were present in 52.9% of participants. Abnormalities were detected in 31.4% by MCH-FS and ASHA-NOMS, and 23.5% by SOMA, which identified a significantly higher frequency of abnormalities in children younger than 36 months. CONCLUSION: More than half of children with IF receiving prolonged PN showed feeding abnormalities. Combined tools may improve identification of feeding difficulties and guide individualized interventions. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Signorini, Alana V AU - Signorini AV AD - Post-Graduate Program of Child and Adolescent Health, Faculdade de Medicina, Universidade Federal Do Rio Grande Do Sul, Hospital de Clinicas de Porto Alegre, Brazil. Electronic address: alanass@gmail.com. FAU - Pires, Giovana Q AU - Pires GQ AD - Post-Graduate Program of Child and Adolescent Health, Faculdade de Medicina, Universidade Federal Do Rio Grande Do Sul, Hospital de Clinicas de Porto Alegre, Brazil. FAU - Ceza, Marilia R AU - Ceza MR AD - Pediatric Gastroenterology Unit, Hospital de Clinicas de Porto Alegre, Brazil. FAU - Adami, Marina R AU - Adami MR AD - Pediatric Gastroenterology Unit, Hospital de Clinicas de Porto Alegre, Brazil. FAU - Kieling, Carlos O AU - Kieling CO AD - Pediatric Gastroenterology Unit, Hospital de Clinicas de Porto Alegre, Brazil. FAU - Goldani, Helena A S AU - Goldani HAS AD - Post-Graduate Program of Child and Adolescent Health, Faculdade de Medicina, Universidade Federal Do Rio Grande Do Sul, Hospital de Clinicas de Porto Alegre, Brazil; Pediatric Gastroenterology Unit, Hospital de Clinicas de Porto Alegre, Brazil; Department of Pediatrics - Faculdade de Medicina, Universidade Federal Do Rio Grande Do Sul, Hospital de Clinicas de Porto Alegre, Brazil. LA - eng PT - Journal Article DEP - 20260924 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM OTO - NOTNLM OT - Feeding and eating disorders of childhood OT - Food fussiness OT - Parenteral nutrition OT - Short bowel syndrome COIS- Conflict of interest The authors declare no conflict of interest. EDAT- 2026/09/24 23:52 MHDA- 2026/09/24 23:52 CRDT- 2026/09/24 19:26 PHST- 2026/07/13 00:00 [received] PHST- 2026/09/15 00:00 [revised] PHST- 2026/09/19 00:00 [accepted] PHST- 2026/09/24 23:52 [pubmed] PHST- 2026/09/24 23:52 [medline] PHST- 2026/09/24 19:26 [entrez] AID - S2405-4577(26)02234-5 [pii] AID - 10.1016/j.clnesp.2026.105137 [doi] PST - aheadofprint SO - Clin Nutr ESPEN. 2026 Sep 24;76:105137. doi: 10.1016/j.clnesp.2026.105137. PMID- 42784400 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260928 IS - 2075-4663 (Electronic) IS - 2075-4663 (Linking) VI - 14 IP - 9 DP - 2026 Sep 14 TI - Classroom Active Breaks Effects on Attention and Concentration Performance Among Adolescents Attending Upper Secondary Schools in Southern Italy. LID - 10.3390/sports14090404 [doi] LID - 404 AB - BACKGROUND: Physical inactivity and prolonged sedentary behavior have been associated with impaired cognitive function during adolescence. Although classroom-based active breaks (ABs) have shown promising effects in primary school children, evidence among adolescents attending upper secondary schools remains limited. This study evaluated the effects of a four-month classroom-based ABs program on attention and concentration performance and explored whether selected participant and lifestyle-related characteristics moderated the intervention response. METHODS: In this cluster-randomized controlled trial, 529 adolescents (302 females, 227 males; 14.3 +/- 0.9 years) from 39 classes attending four upper secondary schools in Southern Italy were included. Classes were randomly allocated to the intervention group (IG; 20 classes, n = 288) or control group (CG; 19 classes, n = 241). The IG participated in two daily 10 min classroom-based ABs for four months, whereas the CG followed the usual school routine. At baseline, anthropometric characteristics, sport participation, sleep duration, daily smartphone use, adherence to the Mediterranean Diet, and concentration performance (CP score), assessed by the d2-R Test of Attention, were evaluated; only CP was reassessed after the intervention. RESULTS: The primary mixed-effects model showed significantly higher adjusted post-intervention CP in the IG than in the CG (adjusted between-group difference = 56.7 points, 95% CI 21.7-91.6; p = 0.003). The intervention effect remained significant in a fully adjusted model including sex, organized sport participation, sleep duration, smartphone use, and Mediterranean Diet adherence (p = 0.004). Exploratory moderator analyses provided no evidence that the intervention effect differed according to any of these characteristics after correction for multiple testing. CONCLUSIONS: A four-month classroom-based ABs program can improve concentration performance among adolescents. High intervention fidelity and student attendance support the feasibility of implementing structured ABs within the school setting over the intervention period. Further research is needed to determine the long-term effects and implementation of ABs program in secondary schools. FAU - Martone, Domenico AU - Martone D AUID- ORCID: 0000-0003-1967-1640 AD - Department of Economics, Law, Cybersecurity and Sport Sciences, University Parthenope, 80133 Naples, Italy. FAU - Vitucci, Daniela AU - Vitucci D AD - Department of Economics, Law, Cybersecurity and Sport Sciences, University Parthenope, 80133 Naples, Italy. FAU - Gillo, Andrea AU - Gillo A AD - Department of Medical, Human Movement and Wellbeing Sciences, University Parthenope, 80133 Naples, Italy. FAU - Dei, Sara AU - Dei S AD - Department of Medical, Human Movement and Wellbeing Sciences, University Parthenope, 80133 Naples, Italy. FAU - Cosco, Loretta Francesca AU - Cosco LF AD - Department of Medical, Human Movement and Wellbeing Sciences, University Parthenope, 80133 Naples, Italy. FAU - Valerio, Giuliana AU - Valerio G AUID- ORCID: 0000-0001-5063-4333 AD - Department of Medical, Human Movement and Wellbeing Sciences, University Parthenope, 80133 Naples, Italy. FAU - Ghirelli, Rosa AU - Ghirelli R AD - Department of Medical, Human Movement and Wellbeing Sciences, University Parthenope, 80133 Naples, Italy. FAU - Alfieri, Andreina AU - Alfieri A AUID- ORCID: 0000-0003-1082-1585 AD - Department of Medical, Human Movement and Wellbeing Sciences, University Parthenope, 80133 Naples, Italy. FAU - Mancini, Annamaria AU - Mancini A AUID- ORCID: 0000-0002-8595-1387 AD - Department of Medical, Human Movement and Wellbeing Sciences, University Parthenope, 80133 Naples, Italy. FAU - Orru, Stefania AU - Orru S AUID- ORCID: 0000-0002-6697-9413 AD - Department of Medical, Human Movement and Wellbeing Sciences, University Parthenope, 80133 Naples, Italy. FAU - Buono, Pasqualina AU - Buono P AUID- ORCID: 0000-0003-0755-6143 AD - Department of Medical, Human Movement and Wellbeing Sciences, University Parthenope, 80133 Naples, Italy. LA - eng GR - I43C23000160005/Parthenope University of Naples/ PT - Journal Article DEP - 20260914 PL - Switzerland TA - Sports (Basel) JT - Sports (Basel, Switzerland) JID - 101722684 PMC - PMC13611686 OTO - NOTNLM OT - active breaks OT - cognitive performance OT - school-based intervention OT - sedentary behavior OT - upper secondary school COIS- The authors declare no conflicts of interest. EDAT- 2026/09/24 23:52 MHDA- 2026/09/24 23:53 PMCR- 2026/09/14 CRDT- 2026/09/24 18:20 PHST- 2026/07/18 00:00 [received] PHST- 2026/09/04 00:00 [revised] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/09/24 23:53 [medline] PHST- 2026/09/24 23:52 [pubmed] PHST- 2026/09/24 18:20 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - sports14090404 [pii] AID - sports-14-00404 [pii] AID - 10.3390/sports14090404 [doi] PST - epublish SO - Sports (Basel). 2026 Sep 14;14(9):404. doi: 10.3390/sports14090404. PMID- 42783660 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260928 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 11 IP - 3 DP - 2026 Sep 10 TI - Immediate Effects of a Pogo-Jump Microdose on Vertical Jump Performance in Adolescent Basketball Players: A Randomized Crossover Pilot Study. LID - 10.3390/jfmk11030366 [doi] LID - 366 AB - Background and Objectives: Low-volume plyometric conditioning may elicit post-activation performance enhancement (PAPE), but the early response to pogo-jump exercise in adolescent basketball players remains uncertain. This randomized crossover pilot study estimated the effect of adding 24 bilateral pogo jumps to a standardized warm-up on countermovement-jump (CMJ) and drop-jump (DJ) height, compared with time-matched low-intensity walking. Methods: Twenty-seven male basketball players were recruited, and 21 (age, 16.55 +/- 0.88 years) completed both conditions. In randomized order, separated by a 7-day washout, participants performed 3 sets of 8 bilateral pogo jumps with 1 min between sets or approximately 3 min of low-intensity walking. Post-condition jump assessments began after a 1 min recovery and comprised three consecutive CMJs, a 30 s transition, and three consecutive DJs, with all measurements completed within approximately 2 min after each condition. The highest valid trial was retained for each jump type. Period-adjusted treatment effects were estimated using separate linear mixed-effects models, with repeated-measures ANOVA and Wilcoxon analyses retained as sensitivity analyses. Results: The period-adjusted between-condition difference in change was -0.89 cm for CMJ (95% CI, -2.92 to 1.14; p = 0.389) and 0.34 cm for DJ (95% CI, -1.77 to 2.45; p = 0.753). Sensitivity analyses yielded the same overall interpretation. All completers performed the protocol, and perceived exertion was 11.4 +/- 1.2. The pogo-jump protocol showed favorable immediate tolerability, with all completers reporting 0/10 anterior-knee pain immediately after the condition. Conclusions: The pilot estimates did not indicate a detectable group-level improvement in CMJ or DJ height during the early post-conditioning assessment. However, the confidence intervals were compatible with potentially meaningful effects in either direction. The small sample, single dose, single early assessment window, and variable DJ reliability limit the precision and generalizability of the findings. FAU - Garcia-Lucas, Celia AU - Garcia-Lucas C AD - Departamento de Ciencias Biomedicas, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, C/Ramon y Cajal, s/n, 46115 Alfara del Patriarca, Spain. FAU - Bivia-Roig, Gemma AU - Bivia-Roig G AUID- ORCID: 0000-0001-7611-5347 AD - Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, Spain. FAU - Pascual-Morales, Ramon AU - Pascual-Morales R AD - Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, Spain. FAU - Escriba-Fuentes, Jorge AU - Escriba-Fuentes J AD - Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, Spain. FAU - Munoz-Martinez, Ivan AU - Munoz-Martinez I AD - Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, Spain. FAU - Samper-Llavador, Sergio AU - Samper-Llavador S AD - Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, Spain. FAU - Llido-Barreres, Francesc Josep AU - Llido-Barreres FJ AD - Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, Spain. FAU - Muzquiz-Barbera, Pedro AU - Muzquiz-Barbera P AUID- ORCID: 0000-0002-9315-0723 AD - Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, Spain. FAU - Lison, Juan Francisco AU - Lison JF AUID- ORCID: 0000-0002-4983-4052 AD - Departamento de Ciencias Biomedicas, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, C/Ramon y Cajal, s/n, 46115 Alfara del Patriarca, Spain. AD - Centre of Physiopathology of Obesity and Nutrition (CIBERobn), CB06/03 Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Amer-Cuenca, Juan Jose AU - Amer-Cuenca JJ AUID- ORCID: 0000-0002-3824-8664 AD - Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Cardenal Herrera-CEU, CEU Universities, 46115 Alfara del Patriarca, Spain. LA - eng PT - Journal Article DEP - 20260910 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC13608166 OTO - NOTNLM OT - adolescent athletes OT - basketball OT - countermovement jump OT - drop jump OT - plyometric exercise OT - pogo jumps OT - post-activation performance enhancement OT - stretch-shortening cycle COIS- The authors declare no conflicts of interest. EDAT- 2026/09/24 23:52 MHDA- 2026/09/24 23:53 PMCR- 2026/09/10 CRDT- 2026/09/24 18:15 PHST- 2026/07/30 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/08 00:00 [accepted] PHST- 2026/09/24 23:53 [medline] PHST- 2026/09/24 23:52 [pubmed] PHST- 2026/09/24 18:15 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - jfmk11030366 [pii] AID - jfmk-11-00366 [pii] AID - 10.3390/jfmk11030366 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2026 Sep 10;11(3):366. doi: 10.3390/jfmk11030366. PMID- 42783582 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260928 IS - 2079-3200 (Electronic) IS - 2079-3200 (Linking) VI - 14 IP - 9 DP - 2026 Sep 15 TI - Sports Emotional Intelligence and Exercise Adherence in Adolescents: The Chain Mediating Role of Exercise Enjoyment and Exercise Identity. LID - 10.3390/jintelligence14090222 [doi] LID - 222 AB - Objective: This study explores the relationship between sports emotional intelligence and exercise adherence in adolescents and constructs a sequential mediation model through the mediating roles of exercise enjoyment and exercise identity. Methods: Using a school-based cross-sectional survey, 1278 adolescents aged 12-18 years from Anhui, Henan, Guangxi, and Chongqing were recruited and completed the Sports Emotional Intelligence Scale, Exercise Enjoyment Scale, Exercise Identity Scale, and Exercise Adherence Scale. Data were analyzed using Mplus 8.1 and SPSS 25.0. Common method bias was assessed with Harman's single-factor test. The measurement model was tested via confirmatory factor analysis, and chain indirect effects were examined using the bootstrap method. Results: The measurement model demonstrated good fit, and all scales showed satisfactory reliability and validity. (1) Sports emotional intelligence was significantly associated with exercise adherence (beta = 0.44, p < 0.001); (2) exercise enjoyment (indirect effect = 0.109) and exercise identity (indirect effect = 0.094) each mediated the relationship, and the sequential path from sports emotional intelligence through exercise enjoyment to exercise identity and then to adherence was also significant (indirect effect = 0.079), with all bias-corrected bootstrap 95% confidence intervals excluding 0. Conclusion: Sports emotional intelligence was positively associated with exercise adherence in adolescents, and this association was partly explained by indirect associations involving exercise enjoyment and exercise identity. The findings suggest that affective valuation and exercise-related self-concept are important correlates within the proposed model. FAU - Bai, Donghuan AU - Bai D AD - School of Physical Education, Huaibei Normal University, Huaibei 235000, China. FAU - Li, Xuerui AU - Li X AD - School of Physical Education, Chongqing University, Chongqing 400044, China. FAU - Song, Pengwei AU - Song P AD - School of Physical Education, Guangxi Science & Technology Normal University, Laibin 546199, China. FAU - Zhang, Jia AU - Zhang J AUID- ORCID: 0000-0002-0107-7152 AD - School of Physical Education, Chongqing University, Chongqing 400044, China. LA - eng GR - 2025CDJSKZK26/Fundamental Research Funds for the Central Universities/ GR - 2024AH053185/the Anhui Provincial Scientific Research Plan Preparation Project/ PT - Journal Article DEP - 20260915 PL - Switzerland TA - J Intell JT - Journal of Intelligence JID - 101635592 PMC - PMC13608465 OTO - NOTNLM OT - adolescent OT - exercise adherence OT - exercise enjoyment OT - exercise identity OT - sports emotional intelligence COIS- The authors declare no conflicts of interest. EDAT- 2026/09/24 23:52 MHDA- 2026/09/24 23:53 PMCR- 2026/09/15 CRDT- 2026/09/24 18:14 PHST- 2026/08/19 00:00 [received] PHST- 2026/09/08 00:00 [revised] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/09/24 23:53 [medline] PHST- 2026/09/24 23:52 [pubmed] PHST- 2026/09/24 18:14 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - jintelligence14090222 [pii] AID - jintelligence-14-00222 [pii] AID - 10.3390/jintelligence14090222 [doi] PST - epublish SO - J Intell. 2026 Sep 15;14(9):222. doi: 10.3390/jintelligence14090222. PMID- 42781822 OWN - NLM STAT- Publisher LR - 20260924 IS - 1098-108X (Electronic) IS - 0276-3478 (Linking) DP - 2026 Sep 24 TI - A Pilot Study of the Feasibility, Acceptability, and Preliminary Outcomes of an Intensive Multidisciplinary Online Intervention Integrating FBT and DBT for Caregivers of Youth With Anorexia Nervosa in China. LID - 10.1002/eat.70216 [doi] AB - OBJECTIVE: This pilot study aimed to examine the feasibility and acceptability of a 12-week intensive, multidisciplinary, synchronous online intervention for caregivers of children and young adults with anorexia nervosa (patient age range: 10-24 years) that integrated Family-Based Therapy (FBT) principles with Dialectical Behavior Therapy (DBT) skills training. A secondary aim was to explore preliminary changes in caregiver and patient outcomes. METHOD: Using a single-arm, pre-post design, 45 caregivers from 26 families (patients' mean age = 16.19 years, SD = 3.57, range = 10-24) completed assessments at baseline (T0), Week 4 (T1), Week 8 (T2), post-intervention (Week 12, T3), and 3-month follow-up (Week 24, T4). The 12-week program (approximately 57 contact hours) comprised weekly theory workshops, multidisciplinary clinical rounds, and skills practice sessions. The primary outcome was caregivers' subjective burden (Zarit Burden Interview, ZBI); secondary outcomes included eating-disorders-related family impact (Eating Disorders Symptom Impact Scale, EDSIS), caregivers' general psychological distress (Depression Anxiety and Stress Scale, DASS-21), and AN patients' Body Mass Index (BMI). Linear mixed models with unstructured covariance structures examined changes over time, with Bonferroni-adjusted pairwise comparisons and Hedges' g effect sizes. RESULTS: The intervention was successfully delivered in an online format and demonstrated acceptable feasibility, with moderate retention across the intervention and follow-up periods. Exploratory clinical analyses suggested significant reductions in caregiver burden (ZBI; F(4, 31.61) = 12.96, p < 0.001) and eating-disorder-related family impact (EDSIS; F(4, 37.19) = 8.78, p < 0.001) over time. Significant improvements emerged by Week 8 and were maintained at follow-up. Patients' BMI also increased significantly across the study period (F(4, 33.95) = 32.65, p < 0.001). In contrast, caregivers' general psychological distress showed no significant improvements relative to baseline. DISCUSSION: This pilot study provides preliminary evidence that an intensive online intervention integrating FBT and DBT can be feasibly delivered and is acceptable to Chinese caregivers of youth with AN. Exploratory findings suggested potential benefits for caregiver burden, eating-disorder-related family impact, and patient BMI; however, the single-arm design precludes conclusions regarding intervention effectiveness. These findings should therefore be considered hypothesis-generating and warrant evaluation in future randomized controlled trials. CI - (c) 2026 Wiley Periodicals LLC. FAU - Zhang, Lei AU - Zhang L AUID- ORCID: 0000-0001-6487-6587 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - OuYang, Hanlai AU - OuYang H AUID- ORCID: 0009-0003-1797-6894 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Ding, Yin AU - Ding Y AUID- ORCID: 0009-0002-7348-4248 AD - Shanghai Zhiai Shenyi Consulting Management Co., Ltd., Shanghai, China. FAU - Peng, Sufang AU - Peng S AUID- ORCID: 0000-0003-2680-9687 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Chen, Han AU - Chen H AUID- ORCID: 0009-0009-4328-1440 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Han, Hui AU - Han H AUID- ORCID: 0000-0003-4014-1070 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Gao, Rui AU - Gao R AUID- ORCID: 0000-0001-7709-201X AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Liu, Yue AU - Liu Y AUID- ORCID: 0009-0009-3440-7603 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Mei, Li AU - Mei L AUID- ORCID: 0000-0002-8015-9438 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Chen, Yan AU - Chen Y AUID- ORCID: 0000-0001-8711-215X AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Han, Huiqin AU - Han H AUID- ORCID: 0000-0002-7278-097X AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Gu, Lian AU - Gu L AUID- ORCID: 0000-0002-3699-8250 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Chen, Jue AU - Chen J AUID- ORCID: 0000-0002-9924-2573 AD - Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. LA - eng GR - 82471573/National Natural Science Foundation of China/ GR - SHDC12023122/Shanghai Hospital Development Center/ GR - 2024-YJ07/Shanghai Mental Health Center/ GR - 2022KTM033/China Medicine Education Association/ PT - Journal Article DEP - 20260924 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM OTO - NOTNLM OT - anorexia nervosa OT - caregivers OT - dialectical behavior therapy OT - family based therapy OT - online intervention OT - subjective burden EDAT- 2026/09/24 23:52 MHDA- 2026/09/24 23:52 CRDT- 2026/09/24 17:15 PHST- 2026/09/06 00:00 [revised] PHST- 2026/06/24 00:00 [received] PHST- 2026/09/10 00:00 [accepted] PHST- 2026/09/24 23:52 [medline] PHST- 2026/09/24 23:52 [pubmed] PHST- 2026/09/24 17:15 [entrez] AID - 10.1002/eat.70216 [doi] PST - aheadofprint SO - Int J Eat Disord. 2026 Sep 24. doi: 10.1002/eat.70216. PMID- 42781539 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260926 IS - 1178-6965 (Print) IS - 1178-6965 (Electronic) IS - 1178-6965 (Linking) VI - 19 DP - 2026 TI - Potential Determinants of Progression from Cough-Variant Asthma to Classic Asthma in Children: Evidence, Mechanisms, and Clinical Research Gaps. PG - 644110 LID - 10.2147/JAA.S644110 [doi] LID - 644110 AB - OBJECTIVE: To synthesize current evidence on host and environmental factors potentially associated with progression of cough variant asthma (CVA) to classic asthma in children, with explicit distinction between direct evidence from pediatric CVA cohorts and indirect evidence extrapolated from general asthma or adult studies, and to identify research gaps for future investigation. DATA SOURCES: PubMed, EMBASE, and Web of Science were searched for studies examining CVA progression, risk factors, and mechanisms in pediatric populations. STUDY SELECTIONS: Original research articles, meta-analyses, and systematic reviews investigating genetic susceptibility, atopy, airway hyperresponsiveness, medication adherence, diet, psychological stress, respiratory infections, allergen exposure, and indoor air pollution in relation to CVA-to-classic asthma progression in children aged <18 years were included. RESULTS: Atopy and airway hyperresponsiveness carry the most consistent evidence. Poor medication adherence is the most readily modifiable risk factor. Environmental triggers include respiratory viral infections (particularly rhinovirus), allergen exposure, and indoor air pollution. These factors converge on Th2-biased immunity, epithelial barrier dysfunction, neuroimmune interactions, and epigenetic reprogramming. A nomogram integrating clinical variables and biomarkers achieved AUCs of 0.929 and 0.914 in training and validation cohorts, respectively, but validated prediction tools for CVA progression remain unavailable. CONCLUSION: Early identification of high-risk children through integrated clinical and biomarker assessment, combined with comprehensive management targeting modifiable risk factors, remains the most rational approach to symptom control, exacerbation prevention, and preservation of lung function; whether this delays progression awaits validation in pediatric interventional trials. CI - (c) 2026 Zheng et al. FAU - Zheng, Kaiwen AU - Zheng K AD - Graduate School, Hebei Medical University, Shijiazhuang, Hebei, 050011, People's Republic of China. AD - Department No. 3 of Respiratory Medicine, Hebei Children's Hospital, Shijiazhuang, Hebei, 050031, People's Republic of China. FAU - Ma, Ran AU - Ma R AD - Graduate School, Hebei Medical University, Shijiazhuang, Hebei, 050011, People's Republic of China. AD - Department No. 3 of Respiratory Medicine, Hebei Children's Hospital, Shijiazhuang, Hebei, 050031, People's Republic of China. FAU - Zhang, Yingqian AU - Zhang Y AD - Department No. 3 of Respiratory Medicine, Hebei Children's Hospital, Shijiazhuang, Hebei, 050031, People's Republic of China. AD - Hebei Provincial Clinical Research Center for Child Health and Disease, Hebei Children's Hospital, Shijiazhuang, Hebei, 050031, People's Republic of China. AD - Hebei Key Laboratory of Pediatric Allergy and Immunology, Hebei Children's Hospital, Shijiazhuang, Hebei, 050031, People's Republic of China. LA - eng PT - Journal Article PT - Review DEP - 20260919 PL - New Zealand TA - J Asthma Allergy JT - Journal of asthma and allergy JID - 101543450 PMC - PMC13599799 OTO - NOTNLM OT - airway inflammation OT - asthma OT - child OT - cough variant asthma OT - disease progression OT - risk factors COIS- The authors declare that they have no competing interests. EDAT- 2026/09/24 17:31 MHDA- 2026/09/24 17:32 PMCR- 2026/09/19 CRDT- 2026/09/24 16:52 PHST- 2026/07/28 00:00 [received] PHST- 2026/09/11 00:00 [accepted] PHST- 2026/09/24 17:32 [medline] PHST- 2026/09/24 17:31 [pubmed] PHST- 2026/09/24 16:52 [entrez] PHST- 2026/09/19 00:00 [pmc-release] AID - 644110 [pii] AID - 10.2147/JAA.S644110 [doi] PST - epublish SO - J Asthma Allergy. 2026 Sep 19;19:644110. doi: 10.2147/JAA.S644110. eCollection 2026. PMID- 42781358 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260926 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Advancing early identification of at-risk children: a consensus-based refinement and validation roadmap for the pediatric malnutrition screening algorithm. PG - 1857903 LID - 10.3389/fnut.2026.1857903 [doi] LID - 1857903 AB - INTRODUCTION: Mild malnutrition risk remains an underrecognized yet clinically important contributor to impaired growth and development in children aged 1-10 years across the Middle East. Regional estimates indicate that 15-25% of children in the Gulf Cooperation Council (GCC) fall within the mild malnutrition risk category (Weight-for-Height Z-score [WHZ] between -1 and -2 SD), a subgroup vulnerable to progressive growth faltering yet excluded from conventional malnutrition diagnostic thresholds (WHZ < -2 SD). The Pediatric Malnutrition Screening Algorithm (PMSA-2025) was refined through a structured regional expert consensus process to enable early, standardized detection of these at-risk children in outpatient and community healthcare settings. METHODS: A 14-member multidisciplinary expert panel from different countries (KSA, UAE, Egypt, Kuwait, Oman, Russia, United States, and Turkiye) refined the PMSA-2025 using a three-round, hybrid modified Delphi approach conducted in September 2025. Expert selection criteria included a minimum of 10 years of clinical or academic experience in pediatric nutrition or gastroenterology, active involvement in malnutrition-related clinical practice or research, and representation of diverse regional healthcare contexts. Content validity was assessed using the Item-level Content Validity Index (I-CVI), with a threshold of >/=0.80 for domain retention. Six clinical domains were retained from an initial pool of eight candidate domains after Delphi-based consensus: perinatal history, growth trajectory, prior nutritional diagnosis, hospitalization frequency, infection recurrence, and feeding behavior. Each domain was operationalized with measurable, age-appropriate criteria and incorporated into a binary (Yes/No) scoring system (total score: 0-6). The tool is designed for use by pediatricians, family physicians, nurses, and trained community health workers in children aged 1-10 years with WHZ between -1 and -2 SD. Exclusion criteria include children with primary chronic systemic disease driving growth impairment and those already receiving formal nutritional support. RESULTS: All six retained domains achieved an Item-level CVI (I-CVI) >/= 0.85 in the final consensus round. Two initial candidate domains (dietary diversity score, caregiver nutritional literacy) were excluded due to insufficient agreement (I-CVI < 0.70). Three domains required definitional refinement during Round 2, achieving >/=90% final agreement in Round 3. The PMSA-2025 stratifies mild malnutrition risk across three tiers: low (0-1), moderate (2-3), and high (4-6). It requires no specialized equipment beyond a standard scale and can be completed within routine consultations. CONCLUSION: The PMSA-2025 represents a consensus-based, multidimensional screening tool with established content validity designed to address the unmet need for early mild malnutrition risk identification in outpatient and community pediatric settings across the Middle East. CI - Copyright (c) 2026 Murray, Shaaban, Shamsah, Al Hammadi, Amin, Almehaidib, Elkhashab, Pyrieva, Al Hammadi, Cetin, Al-Said, AlSaadi, Kamal and ElBaroudy. FAU - Murray, Robert D AU - Murray RD AD - Emeritus Professor of Pediatrics, Pediatric GI and Nutrition, The Ohio State University School of Medicine, Columbus, OH, United States. FAU - Shaaban, Sanaa Y AU - Shaaban SY AD - Professor of Pediatrics, Department of Pediatrics, Consultant of Pediatric Clinical Nutrition, Ain Shams University, Cairo, Egypt. FAU - Shamsah, Abdullah AU - Shamsah A AD - President of Kuwait Pediatric Association, Kuwait, Kuwait. AD - Pediatric & Pediatric Emergency Consultant, Ministry of Health, Kuwait, Kuwait. FAU - Al Hammadi, Ahmed AU - Al Hammadi A AD - Dubai Health Authority, Dubai Medical College, Dubai, United Arab Emirates. FAU - Amin, Ahmed AU - Amin A AD - Abbott Laboratories, Dubai, United Arab Emirates. FAU - Almehaidib, Ali AU - Almehaidib A AD - King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. FAU - Elkhashab, Ehab Khairy AU - Elkhashab EK AD - Pediatric Clinical Nutrition Unit, Ain Shams University, Cairo, Egypt. FAU - Pyrieva, Ekaterina A AU - Pyrieva EA AD - Federal Research Centre of Nutrition, Biotechnology and Food Safety, Moscow, Russia. FAU - Al Hammadi, Entesar AU - Al Hammadi E AD - Dubai Health Authority, Dubai Medical College, Dubai, United Arab Emirates. FAU - Cetin, Funda AU - Cetin F AD - Ege University Faculty of Medicine, Department of Pediatrics, Izmir, Turkiye. FAU - Al-Said, Khoula AU - Al-Said K AD - Department of Paediatric Gastroenterology, Royal Hospital, Muscat, Oman. FAU - AlSaadi, Muslim AU - AlSaadi M AD - Department of Pediatrics, College of Medicine, King Saud University, Riyadh, Saudi Arabia. FAU - Kamal, Naglaa M AU - Kamal NM AD - Department of Pediatrics and Pediatric Hepatology, Kasr Al-Ainy Faculty of Medicine, Cairo, Egypt. FAU - ElBaroudy, Eslam Tawfik AU - ElBaroudy ET AD - Department of Pediatrics, Faculty of Medicine, University of Suez, Suez, Egypt. AD - Department of Health, Kids Heart Medical Center affiliated Columbia University, Abu Dhabi, United Arab Emirates. LA - eng PT - Journal Article PT - Review DEP - 20260909 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13598915 OTO - NOTNLM OT - Middle East OT - Z-score OT - content validity OT - early detection OT - growth monitoring OT - malnutrition OT - pediatric nutrition OT - screening COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author NK declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/09/24 17:31 MHDA- 2026/09/24 17:32 PMCR- 2026/09/09 CRDT- 2026/09/24 16:19 PHST- 2026/04/16 00:00 [received] PHST- 2026/07/09 00:00 [revised] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/09/24 17:32 [medline] PHST- 2026/09/24 17:31 [pubmed] PHST- 2026/09/24 16:19 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.3389/fnut.2026.1857903 [doi] PST - epublish SO - Front Nutr. 2026 Sep 9;13:1857903. doi: 10.3389/fnut.2026.1857903. eCollection 2026. PMID- 42780480 OWN - NLM STAT- MEDLINE DCOM- 20260924 LR - 20260926 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Maternal-fetal adipokine remodeling in obesity-complicated pregnancies: associations with neonatal macrosomia and NICU requirement. PG - 1904956 LID - 10.3389/fendo.2026.1904956 [doi] LID - 1904956 AB - INTRODUCTION: Maternal obesity is associated with altered maternal-fetal adipokine profiles and adverse early neonatal outcomes. This study aimed to characterize maternal and fetal adipokine patterns across obesity severity groups and to evaluate their associations with macrosomia and neonatal intensive care unit (NICU) requirement. METHODS: In this prospective study, 126 singleton pregnancies were stratified into normal-weight, class I obesity, and class II-III obesity groups (n=42 each). Maternal venous and fetal cord blood adiponectin, leptin, asprosin, fetuin-A, retinol-binding protein-4 (RBP-4), adipsin, and glucose transporter-1 (GLUT-1) were assessed at delivery. Macrosomia and NICU requirement were evaluated using group comparisons, receiver operating characteristic (ROC) analyses, and multivariable logistic regression models. RESULTS: Maternal and fetal adipokine profiles differed significantly across obesity severity groups. Maternal fetuin-A, RBP-4, and adipsin levels, along with fetal leptin, fetuin-A, RBP-4, adipsin, and GLUT-1 levels, increased significantly with increasing obesity severity. In ROC analyses, fetal adipsin showed the highest discrimination for macrosomia (AUC=0.951), whereas fetal RBP-4 showed the highest discrimination for NICU requirement (AUC=0.781). In exploratory adjusted analyses, fetal adipsin remained associated with macrosomia (adjusted OR=5.43, 95% CI 2.14-13.77), whereas fetal RBP-4 remained statistically associated with NICU requirement (adjusted OR=3.31, 95% CI 1.87-5.86). DISCUSSION: Maternal obesity is accompanied by distinct maternal and fetal adipokine remodeling at delivery, with fetal adipsin and RBP-4 showing outcome-specific associations with neonatal macrosomia and NICU requirement, respectively. The compartment-specific biomarker patterns further suggest that the fetal metabolic response to increasing maternal adiposity is not simply a reflection of maternal circulating profiles. These exploratory findings warrant validation in larger, independent cohorts. CI - Copyright (c) 2026 Aslaner, Melekoglu, Yasar, Polat, Yilmaz and Basak Turkmen. FAU - Aslaner, Kubra Nur AU - Aslaner KN AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Inonu University, Malatya, Turkiye. FAU - Melekoglu, Rauf AU - Melekoglu R AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Inonu University, Malatya, Turkiye. FAU - Yasar, Seyma AU - Yasar S AD - Department of Biostatistics and Medical Informatics, Faculty of Medicine, Inonu University, Malatya, Turkiye. FAU - Polat, Busra Berfin AU - Polat BB AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Inonu University, Malatya, Turkiye. FAU - Yilmaz, Ercan AU - Yilmaz E AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Inonu University, Malatya, Turkiye. FAU - Basak Turkmen, Nese AU - Basak Turkmen N AD - Faculty of Pharmacy, Inonu University, Malatya, Turkiye. LA - eng PT - Journal Article DEP - 20260909 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Adipokines) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Adipokines/blood MH - *Fetal Macrosomia/blood/etiology/metabolism MH - Infant, Newborn MH - Adult MH - Prospective Studies MH - Fetal Blood/metabolism MH - *Intensive Care Units, Neonatal/statistics & numerical data MH - Biomarkers/blood MH - *Pregnancy in Obesity/blood MH - *Obesity/complications MH - *Pregnancy Complications/blood PMC - PMC13597342 OTO - NOTNLM OT - adipokines OT - adipsin OT - fetuin-A OT - fetus OT - leptin OT - obesity OT - pregnancy OT - retinol-binding protein 4 COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/24 17:31 MHDA- 2026/09/24 17:32 PMCR- 2026/09/09 CRDT- 2026/09/24 12:23 PHST- 2026/06/09 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/24 17:32 [medline] PHST- 2026/09/24 17:31 [pubmed] PHST- 2026/09/24 12:23 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.3389/fendo.2026.1904956 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 9;17:1904956. doi: 10.3389/fendo.2026.1904956. eCollection 2026. PMID- 42780342 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260925 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Effects of different types of physical exercise interventions on aggressive behavior among children and adolescents: a network meta-analysis. PG - 1927181 LID - 10.3389/fpsyg.2026.1927181 [doi] LID - 1927181 AB - INTRODUCTION: Aggressive behavior is a common and important externalizing problem during childhood and adolescence, closely associated with poor social adjustment, subpar academic performance, and adverse mental health outcomes. Although physical exercise has been regarded as a viable nonpharmacological intervention to reduce aggressive behavior, the relative effects of different types of exercise interventions remain unclear. This study used a systematic review and network meta-analysis to compare how different types of physical exercise interventions affect aggression-related outcomes in children and adolescents. METHODS: A systematic literature search across PubMed, Web of Science, Embase, and the China National Knowledge Infrastructure from database inception to December 10, 2025 identified randomized controlled trials (RCTs) and non-randomized controlled trials (non-RCTs) evaluating the effects of physical exercise interventions on aggression-related outcomes in children and adolescents. Based on motor skill characteristics and intervention composition, the interventions were classified into open-skill exercise (OSE), closed-skill exercise (CSE), and multicomponent exercise (MCE). Outcome measures comprised overall aggression, anger, hostility, physical aggression, and verbal aggression. Random effects models were used to conduct conventional pairwise meta-analyses and network meta-analyses, expressing effect sizes as standardized mean differences (SMDs) with 95% confidence intervals (CIs). Surface under the cumulative ranking curve (SUCRA) values determined intervention rankings, and consistency tests, meta-regression, and sensitivity analyses evaluated finding robustness. RESULTS: This analysis included 25 studies involving 2,772 children and adolescents. Compared with control conditions, physical exercise interventions significantly mitigated negative aggression-related outcomes, including hostility (SMD = -0.37, 95% CI: -0.62 to -0.13), anger (SMD = -0.64, 95% CI: -1.00 to -0.27), overall aggression (SMD = -0.87, 95% CI: -1.36 to -0.39), and physical aggression (SMD = -0.70, 95% CI: -0.91 to -0.49). Conversely, the mitigation of verbal aggression lacked statistical significance (SMD = -0.05, 95% CI: -0.36 to 0.25). For outcomes permitting treatment network construction, the global consistency test indicated no significant inconsistency. SUCRA ranking results revealed that MCE ranked highest for hostility (79.4%) and physical aggression (74.7%), CSE ranked highest for anger (85.9%), and OSE ranked highest for overall aggression (84.4%). Meta-regression identified no significant moderators. CONCLUSION: Physical exercise interventions may help improve certain aggression-related outcomes in children and adolescents, although the effects are not entirely consistent across different outcomes. These findings suggest that exercise modalities possessing different skill characteristics may differ in their effects on hostility, anger, overall aggression, and physical aggression. Consequently, practitioners designing interventions for aggressive behavior in children and adolescents may consider the target outcome when selecting exercise programs. Given the substantial between-study heterogeneity and scarce head-to-head comparative evidence, additional high-quality RCTs are needed to validate these findings further. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD42026133695, identifier (CRD420261336959). CI - Copyright (c) 2026 Zhang and Lee. FAU - Zhang, Yuhang AU - Zhang Y AD - Department of Physical Education, Kyungpook National University, Daegu, Republic of Korea. FAU - Lee, Gyuil AU - Lee G AD - Department of Physical Education, Kyungpook National University, Daegu, Republic of Korea. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260909 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13597820 OTO - NOTNLM OT - aggressive behavior OT - children and adolescents OT - network meta-analysis OT - physical exercise interventions OT - systematic review COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/24 12:49 MHDA- 2026/09/24 12:50 PMCR- 2026/09/09 CRDT- 2026/09/24 11:02 PHST- 2026/07/03 00:00 [received] PHST- 2026/08/16 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/09/24 12:50 [medline] PHST- 2026/09/24 12:49 [pubmed] PHST- 2026/09/24 11:02 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1927181 [doi] PST - epublish SO - Front Psychol. 2026 Sep 9;17:1927181. doi: 10.3389/fpsyg.2026.1927181. eCollection 2026. PMID- 42780328 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260925 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Body mass index is positively associated with flatfoot and inversely associated with hindfoot valgus in school-aged children: a cross-sectional analysis of 3,292 screening records. PG - 1930830 LID - 10.3389/fped.2026.1930830 [doi] LID - 1930830 AB - BACKGROUND: A higher body mass index (BMI) has been associated with pediatric flatfoot, but it is unclear whether BMI relates similarly to arch morphology, hallux alignment, and hindfoot alignment when these measures are collected within the same school-screening workflow. Herein, we examined phenotype-specific associations between BMI and three scanner-derived foot measures. METHODS: This secondary cross-sectional analysis linked project-based school foot-screening records to on-site anthropometric measurements. After linkage and quality-control exclusions, 3,292 records from six primary schools were analyzed. Record-level outcomes were moderate-to-severe flatfoot (arch index >/= 0.28), mild hallux valgus (15 degrees to <30 degrees ), and moderate-to-severe hindfoot valgus (>/=4 degrees ), with positivity defined by either foot. BMI was analyzed in sample-specific quartiles and per 1 internal SD. Multivariable binary logistic regression adjusted for age, sex, and school; threshold and duplicate-identifier sensitivity analyses were performed. RESULTS: The 3,292 records represented 3,266 unique school-student identifiers; median age was 10 years (IQR: 9-12), and There were 1,616 female records (49.1%). Screening prevalence was 64.3% for flatfoot, 11.5% for mild hallux valgus, and 52.8% for hindfoot valgus. Each 1-SD higher BMI (4.73 kg/m(2)) was associated with higher odds of flatfoot [odds ratio (OR): 1.37, 95% CI: 1.26-1.49; P < 0.001] and lower odds of hindfoot valgus (OR: 0.82, 95% CI: 0.76-0.88; P < 0.001), while mild hallux valgus showed no statistically significant association (OR: 0.93, 95% CI: 0.82-1.05; P = 0.244). More stringent threshold analyses and analyses retaining one record per identifier produced materially similar BMI associations. CONCLUSIONS: BMI was positively associated with flatfoot and inversely associated with hindfoot valgus, while no significant association was observed for mild hallux valgus. These cross-sectional associations describe operational scanner-derived screening phenotypes and should not be interpreted as causal effects or clinical diagnoses. Prospective studies with documented anthropometric quality control and validated clinical or radiographic measures are needed. CI - (c) 2026 Li, Li, Huo, Xu, Wang, Zhou, Dong, Song, Yang and Wang. FAU - Li, Shanyuan AU - Li S AD - Department of Rehabilitation, Tangshan Second Hospital, Tangshan, Hebei, China. AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Li, Dongmei AU - Li D AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Huo, Yongxin AU - Huo Y AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Xu, Ying AU - Xu Y AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Wang, Yuhang AU - Wang Y AD - Tianjin Delijie Medical Devices Co., Ltd., Tianjin, China. FAU - Zhou, Hongyan AU - Zhou H AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Dong, Xinyang AU - Dong X AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Song, Ying AU - Song Y AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Yang, Weixin AU - Yang W AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. FAU - Wang, Bin AU - Wang B AD - Institute of Traumatology, Tangshan Second Hospital, Tangshan, Hebei, China. LA - eng PT - Journal Article DEP - 20260909 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13597771 OTO - NOTNLM OT - body mass index OT - flatfoot OT - hallux valgus OT - hindfoot valgus OT - pediatric orthopedics OT - school screening COIS- YW was employed by Tianjin Delijie Medical Devices Co., Ltd., the manufacturer of the foot analysis instrument used in this study. The remaining author(s) declared that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/24 12:49 MHDA- 2026/09/24 12:50 PMCR- 2026/09/09 CRDT- 2026/09/24 10:58 PHST- 2026/07/07 00:00 [received] PHST- 2026/08/11 00:00 [revised] PHST- 2026/08/13 00:00 [accepted] PHST- 2026/09/24 12:50 [medline] PHST- 2026/09/24 12:49 [pubmed] PHST- 2026/09/24 10:58 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.3389/fped.2026.1930830 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 9;14:1930830. doi: 10.3389/fped.2026.1930830. eCollection 2026. PMID- 42780256 OWN - NLM STAT- MEDLINE DCOM- 20260924 LR - 20260925 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Interpretable skeleton-based movement profiles for formative feedback in school physical activity education. PG - 1925220 LID - 10.3389/fpubh.2026.1925220 [doi] LID - 1925220 AB - BACKGROUND: Schools are an important setting for developing movement competence and supporting physical activity PA). Teachers provide feedback on how learners move, but individualized observation is difficult to sustain and document in large classes. Existing artificial intelligence (AI) systems typically classify an action or predict one competitive-sport score. These outputs do not identify the specific movement feature that a learner might adjust during practice. METHODS: Using three public human action datasets (NTU RGB+D, Penn Action, and a FineGym subset), we benchmarked five representative skeleton-sequence models-recurrent (LSTM, GRU), graph-based (ST-GCN, CTR-GCN), and a Transformer-under a unified setting, and constructed four interpretable movement-profile indicators from joint coordinates and trajectories: movement amplitude, postural stability, left-right coordination, and temporal consistency. Each indicator was normalized against the same-class reference distribution, providing a relative, interpretable description rather than an expert-certified score. RESULTS: Over five random seeds per dataset, independent-test macro-F1 ranged from 0.76 to 0.97; CTR-GCN obtained the highest mean on every dataset (NTU RGB+D 0.970 +/- 0.003). Paired tests supported its advantage over all four comparators on NTU RGB+D and FineGym, whereas on Penn Action only the comparison with LSTM remained significant after correction. In the feature ablation, the full kinematic input increased macro-F1 from 0.925 to 0.936 on 3D skeletons (Holm-adjusted p = 0.022); the corresponding 2D change from 0.893 to 0.905 was not significant after correction (p = 0.079). Per-action profiles and a same-action case analysis showed that the indicators capture interpretable kinematic structure. The resulting percentiles describe relative tendencies within these datasets; a low percentile does not by itself identify an incorrect movement or constitute an age-appropriate standard for children. CONCLUSION: Skeleton-only movement profiles offer a privacy-reducing, teacher-in-the-loop approach to formative feedback that could support digital PA education and health promotion in schools. As a computational proof-of-concept evaluated on public datasets, the study does not include health or learning outcomes, age-specific K-12 reference distributions, or authentic-classroom validation. Calibration on curriculum-relevant data from children and validation against teacher or movement-expert ratings are required before the profiles can be interpreted as movement-quality feedback or used to support public-health claims. CI - Copyright (c) 2026 Ma, Lei, Li, Yang, Du, Zhu, Zhao and Jia. FAU - Ma, Qixuan AU - Ma Q AD - University of Macau, Taipa, Macau SAR, China. FAU - Lei, Xiao AU - Lei X AD - University of Macau, Taipa, Macau SAR, China. FAU - Li, Feng AU - Li F AD - Institute of Orthopaedics, Nankai University, Tianjin, China. AD - Eugene WuKangYuan (Hangzhou) Health Technology Co., Ltd, Hangzhou, China. FAU - Yang, Chengmao AU - Yang C AD - Institute of Orthopaedics, Nankai University, Tianjin, China. AD - State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China. FAU - Du, Jinsui AU - Du J AD - Xiguan Guangya Experimental School, Liwan District, Guangzhou, China. FAU - Zhu, Jiaxing AU - Zhu J AD - Institute of Orthopaedics, Nankai University, Tianjin, China. AD - Eugene WuKangYuan (Hangzhou) Health Technology Co., Ltd, Hangzhou, China. FAU - Zhao, Dongxin AU - Zhao D AD - Shaanxi University of Technology, Hanzhong, China. FAU - Jia, Zhenghu AU - Jia Z AD - Institute of Orthopaedics, Nankai University, Tianjin, China. AD - Eugene WuKangYuan (Hangzhou) Health Technology Co., Ltd, Hangzhou, China. AD - State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin, China. LA - eng PT - Journal Article DEP - 20260909 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Schools MH - *Physical Education and Training/methods MH - *Exercise/physiology MH - *Formative Feedback MH - Movement/physiology MH - Artificial Intelligence MH - Child PMC - PMC13597747 OTO - NOTNLM OT - digital health education OT - formative feedback OT - knowledge of performance OT - movement competence OT - physical activity promotion OT - school physical activity education OT - skeleton-based action recognition COIS- FL, JZ, and ZJ were employed by Eugene WuKangYuan (Hangzhou) Health Technology Co., Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/24 12:49 MHDA- 2026/09/24 12:50 PMCR- 2026/09/09 CRDT- 2026/09/24 10:27 PHST- 2026/07/01 00:00 [received] PHST- 2026/08/07 00:00 [revised] PHST- 2026/08/12 00:00 [accepted] PHST- 2026/09/24 12:50 [medline] PHST- 2026/09/24 12:49 [pubmed] PHST- 2026/09/24 10:27 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1925220 [doi] PST - epublish SO - Front Public Health. 2026 Sep 9;14:1925220. doi: 10.3389/fpubh.2026.1925220. eCollection 2026. PMID- 42779848 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260924 LR - 20260930 IS - 2587-1250 (Electronic) IS - 2587-0823 (Print) IS - 2587-1250 (Linking) VI - 72 IP - 3 DP - 2026 Sep 24 TI - Physical activity and exercise in pediatric oncology: conceptual distinctions and clinical implications. PG - 275-282 LID - 10.4274/tftrd.2026.18471 [doi] AB - Survival in childhood cancers has markedly improved, yet many children experience treatment-related difficulties such as persistent fatigue, muscle weakness, reduced endurance, and impaired quality of life. As interest in non-pharmacological approaches grows, movement-based strategies, ranging from general physical activity to structured exercise, have become increasingly prominent in pediatric oncology care. This review aims to clarify the conceptual and practical differences between physical activity and structured exercise, and to summarize current evidence on movement-based interventions used during active treatment and survivorship in children and adolescents with cancer. Drawing on quantitative and qualitative studies published between 2000 and 2025, it shows that priorities shift across treatment phases: safety and feasibility are emphasized during active therapy, whereas long-term health and functional recovery gain importance in survivorship. The findings highlight the need for clearer terminology, coordinated multidisciplinary practice, meaningful family involvement, and consistent outcome measures with longer-term follow-up in future research. CI - (c)Copyright 2026 The Author(s). Published by Galenos Publishing House on behalf of the Turkish Society of Physical Medicine and Rehabilitation. FAU - Aydin, Ayse Resa AU - Aydin AR AUID- ORCID: 0000-0002-8496-7424 AD - Department of Physical Medicine and Rehabilitation, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkiye. FAU - Berktas, Yagmur AU - Berktas Y AUID- ORCID: 0000-0002-2221-3029 AD - Department of Supportive Treatment and Care in Cancer Patients, Istanbul University Institute of Health Sciences, Istanbul, Turkiye. LA - eng PT - Journal Article PL - Turkey TA - Turk J Phys Med Rehabil JT - Turkish journal of physical medicine and rehabilitation JID - 101719024 PMC - PMC13617965 OTO - NOTNLM OT - Pediatric oncology OT - childhood cancer OT - exercise OT - physical activity OT - rehabilitation OT - survivorship COIS- Ayse Resa Aydin, MD, is a member of the Scientific Advisory Board of the Turkish Journal of Physical Medicine and Rehabilitation. She was not involved in the peer-review process of this article and had no access to any information regarding its evaluation. The other author has no conflicts of interest to declare. EDAT- 2026/09/24 13:06 MHDA- 2026/09/24 13:07 PMCR- 2026/09/24 CRDT- 2026/09/24 06:24 PHST- 2026/09/24 13:07 [medline] PHST- 2026/09/24 13:06 [pubmed] PHST- 2026/09/24 06:24 [entrez] PHST- 2026/09/24 00:00 [pmc-release] AID - 10.4274/tftrd.2026.18471 [doi] PST - ppublish SO - Turk J Phys Med Rehabil. 2026 Sep 24;72(3):275-282. doi: 10.4274/tftrd.2026.18471. PMID- 42779038 OWN - NLM STAT- MEDLINE DCOM- 20260924 LR - 20260929 IS - 1547-1896 (Print) IS - 0893-7400 (Linking) VI - 39 IP - 10 DP - 2026 Oct 1 TI - Diagnosis and management of ankyloglossia in infants and children. PG - 32-36 LID - 10.1097/01.JAA.0000000000000420 [doi] AB - The diagnosis and management of ankyloglossia, commonly referred to as tongue-tie, has become a controversial topic spanning multiple subspecialties within pediatrics, dentistry, and rehabilitation medicine. Changing perspectives on clinical significance, increased awareness of breastfeeding challenges, and a stronger emphasis on a multidisciplinary approach have contributed to a dramatic rise in both diagnosis and intervention in this condition. Between 1997 and 2012, inpatient diagnoses of ankyloglossia in the United States increased nearly 10-fold, from 3,934 to 32,837 cases, with a similar increase in lingual frenotomy procedures, from 1,279 to 12,406. Providers may encounter tongue-tie in diverse settings, ranging from the newborn nursery to outpatient pediatric primary care to otolaryngology clinics. In the absence of a validated standalone threshold for surgical intervention, clinical decision-making can be challenging. This article provides clinically relevant, evidence-based recommendations to guide the diagnosis and management of ankyloglossia. Current guidance emphasizes direct assessment of the breastfeeding dyad, skilled lactation support, close monitoring of milk transfer and growth, and treatment of competing causes before frenotomy is considered. CI - Copyright (c) 2026 American Academy of Physician Associates. FAU - Fridman, Mark A AU - Fridman MA AD - Mark A. Fridman practices pediatric otolaryngology at Joe DiMaggio Children's Hospital in Hollywood, FL. The author has disclosed no potential conflicts of interest, financial or otherwise. LA - eng PT - Journal Article PT - Review DEP - 20260924 PL - United States TA - JAAPA JT - JAAPA : official journal of the American Academy of Physician Assistants JID - 9513102 SB - IM MH - Humans MH - *Ankyloglossia/diagnosis/therapy/surgery MH - Breast Feeding MH - Infant MH - Oral Frenectomy MH - Infant, Newborn MH - Child MH - Lingual Frenum/abnormalities/surgery MH - Female MH - Child, Preschool MH - Practice Guidelines as Topic OTO - NOTNLM OT - ankyloglossia OT - breastfeeding OT - multidisciplinary OT - otolaryngology OT - pediatrics OT - tongue-tie EDAT- 2026/09/24 05:37 MHDA- 2026/09/24 05:38 CRDT- 2026/09/24 01:14 PHST- 2026/09/24 05:38 [medline] PHST- 2026/09/24 05:37 [pubmed] PHST- 2026/09/24 01:14 [entrez] AID - 01720610-202610000-00004 [pii] AID - 10.1097/01.JAA.0000000000000420 [doi] PST - ppublish SO - JAAPA. 2026 Oct 1;39(10):32-36. doi: 10.1097/01.JAA.0000000000000420. Epub 2026 Sep 24. PMID- 42777493 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261022 IS - 1872-6283 (Electronic) IS - 0379-0738 (Linking) VI - 389 DP - 2026 Dec TI - A novel four-teeth model for dental age estimation: Reliability, validity, and comparative accuracy with a seven-teeth approach. PG - 113142 LID - S0379-0738(26)00330-0 [pii] LID - 10.1016/j.forsciint.2026.113142 [doi] AB - Dental age estimation plays a critical role in forensic identification and legal age determination, particularly in children and adolescents. Although multi-tooth regression models demonstrate high predictive accuracy, their application may be restricted in situations involving incomplete dentition or suboptimal radiographic visualization. The present study aimed to develop and validate a simplified four-teeth model for dental age estimation and to compare its performance with established seven-teeth models. A cross-sectional study was conducted using 2000 panoramic radiographs of Indian children aged 5-16 yrs. Dental maturity was assessed using the normalized open apices method. A regression equation based on four mandibular posterior teeth (34, 35, 36, 37) was derived using stepwise multiple linear regression and validated on an test dataset (n = 500). Model performance was evaluated using coefficient of determination (R(2)), Root Mean Square Error (RMSE), and Mean Absolute Error (MAE), and compared with Prabhu's population-specific and Cameriere's seven-teeth models. The four-teeth model demonstrated good predictive ability (R(2) = 69.6%, p < 0.0001), with an overall RMSE of 1.15 yrs and MAE of 0.95 yrs. The highest accuracy was observed in the 9-13 yrs age group (RMSE = 0.98 yrs), where performance was comparable to the seven-teeth models. Prediction error increased in the 13-16-yrs group (RMSE = 1.50 yrs), reflecting reduced discriminatory information following completion of root development. The model may therefore be useful as a simplified adjunct for dental age estimation primarily during the 5-13-yrs developmental period, in cases of incomplete dentition or compromised radiographic quality while external validation is required before broader forensic application. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Prabhu, Rachana AU - Prabhu R AD - Department of Oral Medicine & Radiology, Yenepoya Dental College, Yenepoya (Deemed to be University), India. Electronic address: rachanaprabhu@yenepoya.edu.in. FAU - Yashaswini, K AU - Yashaswini K AD - Department of Biostatistics, Nitte Institute of Allied Health Sciences, K.S.Hegde Medical Academy, Nitte (Deemed to be University), India. FAU - Shenoy, Prashanth AU - Shenoy P AD - Department of Oral Medicine & Radiology, Yenepoya Dental College, Yenepoya (Deemed to be University), India. FAU - Prabhu, Vishnudas AU - Prabhu V AD - Department of Oral & Maxillofacial Pathology, Yenepoya Dental College, Yenepoya (Deemed to be University), India. FAU - Chatra, Laxmikanth AU - Chatra L AD - Department of Oral Medicine & Radiology, Yenepoya Dental College, Yenepoya (Deemed to be University), India. LA - eng PT - Comparative Study PT - Journal Article PT - Validation Study DEP - 20260918 PL - Ireland TA - Forensic Sci Int JT - Forensic science international JID - 7902034 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Child MH - Radiography, Panoramic MH - Adolescent MH - Child, Preschool MH - Reproducibility of Results MH - Forensic Dentistry/methods MH - Cross-Sectional Studies MH - Linear Models MH - Male MH - Female MH - Tooth Apex/diagnostic imaging/growth & development OTO - NOTNLM OT - Dental age estimation OT - Forensic odontology OT - Four teeth model OT - Open apices OT - Regression analysis COIS- Declaration of Competing Interest declare that there is no conflict of interest in submission of the same for publication in your esteemed journal. EDAT- 2026/09/23 23:56 MHDA- 2026/10/22 23:28 CRDT- 2026/09/23 18:07 PHST- 2026/04/24 00:00 [received] PHST- 2026/09/09 00:00 [revised] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/10/22 23:28 [medline] PHST- 2026/09/23 23:56 [pubmed] PHST- 2026/09/23 18:07 [entrez] AID - S0379-0738(26)00330-0 [pii] AID - 10.1016/j.forsciint.2026.113142 [doi] PST - ppublish SO - Forensic Sci Int. 2026 Dec;389:113142. doi: 10.1016/j.forsciint.2026.113142. Epub 2026 Sep 18. PMID- 42777468 OWN - NLM STAT- Publisher LR - 20260923 IS - 1872-7654 (Electronic) IS - 0301-2115 (Linking) VI - 327 DP - 2026 Sep 19 TI - Construction and verification of a prediction model for gestational diabetes mellitus complicated with gestational hypertension based on a specialized disease research database. PG - 115449 LID - S0301-2115(26)00517-8 [pii] LID - 10.1016/j.ejogrb.2026.115449 [doi] AB - OBJECTIVE: To construct and validate a model for predicting the risk of gestational hypertension disorder (HDP) in pregnant women with gestational diabetes mellitus (GDM) and to explore the nonlinear association between key metabolic indicators and the risk of HDP. METHOD: This study was a multicenter retrospective cohort study. Data were derived from the GDM-specific databases of multiple collaborating hospitals and included singleton pregnant women with GDM from May 29, 2018 to October 30, 2025. A total of 1,500 pregnant women were included in the analysis, of which 123 (8.2%) developed HDP. Using Boruta algorithm for feature screening, the optimal breakpoint determined based on restricted cubic spline (RCS) is used to convert continuous variables into binary variables, and a multivariable logistic regression is used to construct a prediction model; Apply RCS and segmented regression to analyze the nonlinear effects and thresholds of key continuous variables. Internal validation was conducted using Bootstrap resampling, and the clinical net benefit of the model was evaluated using decision curve analysis (DCA). RESULTS: The final prediction model included six variables: pre pregnancy BMI >/= 25 kg/m (2) (OR = 1.92, 95% CI 1.28-2.87), assisted reproductive conception (OR = 1.80, 95% CI 1.07-3.04), history of adverse pregnancy and childbirth (OR = 1.54, 95% CI 0.97-2.47), HOMA-IR /= 2.867 mmol/L (OR = 1.81, 95% CI 0.91-3.59), and age >/= 35 years (OR = 1.32, 95% CI 0.89-1.94). There is a significant non-linear correlation between HOMA-IR and triglyceride levels in early pregnancy and HDP risk, with thresholds of 2.600 and 2.867 mmol/L, respectively. When the threshold is below, the risk increases sharply with the increase of indicators. After internal validation, the final model had a corrected C-index of 0.644 (AUC = 0.665), with acceptable calibration accuracy. Decision curve analysis shows that when the decision threshold is between 2% and 18%, applying the model to guide clinical intervention can bring net benefits. CONCLUSION: We constructed a moderately‑performing HDP risk‑prediction model for GDM‑complicating pregnancies using accessible clinical variables for auxiliary risk stratification, with HOMA‑IR and TG exploratory thresholds needing prospective validation before clinical use. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Gao, Lan AU - Gao L AD - Department of Endocrinology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou City 570311, Hainan Province, China. FAU - Wang, Fei AU - Wang F AD - Department of Endocrinology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou City 570311, Hainan Province, China. FAU - Ji, Qun AU - Ji Q AD - Department of Endocrinology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou City 570311, Hainan Province, China. FAU - Chen, ChunLan AU - Chen C AD - Department of Endocrinology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou City 570311, Hainan Province, China. FAU - Lin, CaiQiong AU - Lin C AD - Department of Endocrinology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou City 570311, Hainan Province, China. FAU - Lu, Min AU - Lu M AD - Department of Obstetrics and Gynecology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou City 570311, Hainan Province, China. FAU - Chen, KaiNing AU - Chen K AD - Department of Endocrinology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou City 570311, Hainan Province, China. FAU - Liu, HaiWei AU - Liu H AD - Department of Endocrinology, Hainan General Hospital (Hainan Affiliated Hospital of Hainan Medical University), Haikou City 570311, Hainan Province, China. Electronic address: hndxlhw@126.com. LA - eng PT - Journal Article DEP - 20260919 PL - Ireland TA - Eur J Obstet Gynecol Reprod Biol JT - European journal of obstetrics, gynecology, and reproductive biology JID - 0375672 SB - IM OTO - NOTNLM OT - Decision Curve analysis OT - Gestational diabetes mellitus OT - Hypertensive disorders in pregnancy OT - Nomogram OT - Predictive models OT - Threshold effect COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/23 23:56 MHDA- 2026/09/23 23:56 CRDT- 2026/09/23 18:06 PHST- 2025/12/24 00:00 [received] PHST- 2026/08/25 00:00 [revised] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/09/23 23:56 [medline] PHST- 2026/09/23 23:56 [pubmed] PHST- 2026/09/23 18:06 [entrez] AID - S0301-2115(26)00517-8 [pii] AID - 10.1016/j.ejogrb.2026.115449 [doi] PST - aheadofprint SO - Eur J Obstet Gynecol Reprod Biol. 2026 Sep 19;327:115449. doi: 10.1016/j.ejogrb.2026.115449. PMID- 42777335 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261014 IS - 2352-3964 (Electronic) IS - 2352-3964 (Linking) VI - 132 DP - 2026 Oct TI - Metabolomic profiling of ultra-processed food consumption and cardiovascular risk in Spanish preschool children: a cross-sectional study. PG - 106488 LID - S2352-3964(26)00372-5 [pii] LID - 10.1016/j.ebiom.2026.106488 [doi] LID - 106488 AB - BACKGROUND: Ultra-processed food (UPF) consumption has increased substantially among children worldwide and has been associated with early cardiovascular alterations. We aimed to identify plasma metabolomic profiles associated with UPF consumption in children aged 3-6 years and to assess their association with cardiovascular risk factors. METHODS: This cross-sectional analysis used baseline data from the Childhood Obesity Risk Assessment Longitudinal Study (CORALS), with children recruited between March 2019 and June 2022 through primary schools and health-care centres in seven Spanish cities. 1148 children were included (mean age 5.0 years [SD 1.1]; 50.6% girls) after exclusions due to medical conditions and incomplete or implausible dietary or metabolomic data. Energy-adjusted UPF intake (g/d) was assessed using a validated food frequency questionnaire and categorised with NOVA classification. 249 metabolites were quantified by NMR-based metabolomics, and lipid-related and amino acid-related profiles/scores were derived. A composite cardiovascular risk score (CVRs) was constructed by summing sex-specific, age-adjusted z-scores for fat-mass index, HDL-and LDL-cholesterol, triglycerides, mean arterial pressure, and Homoeostatic Model Assessment for Insulin Resistance. FINDINGS: 19 metabolites were associated with UPF consumption after false discovery rate correction (FDR). A lipid-related score was positively associated with CVRs (beta = 0.511; 95% CI: 0.413-0.610; FDR <0.001) and the amino acid-related score was associated with a lower CVRs (beta = -0.494; 95% CI: -0.667 to -0.321; FDR <0.001). Discrimination of cardiovascular risk beyond covariates alone was higher after inclusion of metabolomic scores, particularly when both scores were considered jointly (DeltaAUC 0.092, 95% CI: 0.013-0.172; p = 0.020). INTERPRETATION: In Spanish pre-schoolers UPF-related metabolomic profiles were associated with different cardiovascular risk factors. These diet-related metabolomic scores capture biological correlates relevant to early cardiovascular health and align with early-life metabolic pattering, supporting future longitudinal studies and prevention strategies. FUNDING: CIBEROBN; Instituto de Salud Carlos III (ISCIII-FIS; EU ERDF/ESF); ISCIII PFIS. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Perez-Acosta, Josue A AU - Perez-Acosta JA AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Garcia-Gavilan, Jesus F AU - Garcia-Gavilan JF AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Margara-Escudero, Hernando J AU - Margara-Escudero HJ AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Aguilera, Concepcion M AU - Aguilera CM AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology (INYTA) and Center of Biomedical Research (CIBM), University of Granada, Granada, 18071, Spain; Instituto de Investigacion Biosanitaria ibs.GRANADA, Granada, Spain. FAU - Leis, Rosaura AU - Leis R AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Unit of Pediatric Gastroenterology, Hepatology and Nutrition, Pediatric Service, Hospital Clinico Universitario de Santiago, 15706, Santiago de Compostela, Spain; Pediatric Nutrition Research Group, Health Research Institute of Santiago de Compostela (IDIS). Unit of Investigation in Nutrition, Growth and Human Development of Galicia-USC, 15706, Santiago de Compostela, Spain. FAU - Gheorghita, Irina AU - Gheorghita I AD - Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Universitat Rovira i Virgili, Pediatric Nutrition and Human Development Research Unit (PediNuR), Reus, Spain. FAU - Miguel-Berges, Maria L AU - Miguel-Berges ML AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Growth, Exercise, Nutrition and Development (GENUD-B34_23R) Research Group, Facultad de Ciencias de la Salud e Instituto Agroalimentario de Aragon (IA2) University of Zaragoza, Zaragoza, Spain. FAU - Navas-Carretero, Santiago AU - Navas-Carretero S AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; University of Navarra, Center for Nutrition Research, 31008, Pamplona, Spain; Universidad de Navarra, Instituto de Nutricion y Salud, 31080, Pamplona, Spain; IdisNA, Navarra Institute for Health Research, Pamplona, Spain. FAU - Sorli, Jose V AU - Sorli JV AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Department of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain. FAU - Lazaro, Iolanda AU - Lazaro I AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Hospital del Mar Research Institute, Barcelona, Spain. FAU - Pastor-Villaescusa, Belen AU - Pastor-Villaescusa B AD - Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS), RD21/0012/0008, Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS-SAMID, RD24/0013/0007), Instituto de Salud Carlos III (ISCIII), 28029, Madrid, Spain; Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba; Cordoba, 14071, Spain. FAU - Vazquez-Cobela, Rocio AU - Vazquez-Cobela R AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Unit of Pediatric Gastroenterology, Hepatology and Nutrition, Pediatric Service, Hospital Clinico Universitario de Santiago, 15706, Santiago de Compostela, Spain; Pediatric Nutrition Research Group, Health Research Institute of Santiago de Compostela (IDIS). Unit of Investigation in Nutrition, Growth and Human Development of Galicia-USC, 15706, Santiago de Compostela, Spain. FAU - Iglesias-Vazquez, Lucia AU - Iglesias-Vazquez L AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - De Miguel-Etayo, Pilar AU - De Miguel-Etayo P AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Growth, Exercise, Nutrition and Development (GENUD-B34_23R) Research Group, Facultad de Ciencias de la Salud e Instituto Agroalimentario de Aragon (IA2) University of Zaragoza, Zaragoza, Spain; Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. FAU - Vazquez-Bolea, Natalia AU - Vazquez-Bolea N AD - University of Navarra, Center for Nutrition Research, 31008, Pamplona, Spain; Universidad de Navarra, Instituto de Nutricion y Salud, 31080, Pamplona, Spain. FAU - Jurado-Castro, Jose Manuel AU - Jurado-Castro JM AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba; Cordoba, 14071, Spain. FAU - Picans-Leis, Rosaura AU - Picans-Leis R AD - Neonatology Service, RICORS-SAMID-CIBERER, University Clinical Hospital of Santiago de Compostela, Health Research Institute of Santiago de Compostela, Santiago de Compostela, Spain. FAU - Escribano, Joaquin AU - Escribano J AD - Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Universitat Rovira i Virgili, Pediatric Nutrition and Human Development Research Unit (PediNuR), Reus, Spain; Hospital Universitari Sant Joan de Reus, Servicio de Pediatria, Reus, Spain. FAU - Moreno, Luis A AU - Moreno LA AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Growth, Exercise, Nutrition and Development (GENUD-B34_23R) Research Group, Facultad de Ciencias de la Salud e Instituto Agroalimentario de Aragon (IA2) University of Zaragoza, Zaragoza, Spain; Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. FAU - Torre-Aguilar, MJose de la AU - Torre-Aguilar M AD - Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba; Cordoba, 14071, Spain. FAU - Gil-Campos, Mercedes AU - Gil-Campos M AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain; Metabolism and Investigation Unit, Reina Sofia University Hospital, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), University of Cordoba; Cordoba, 14071, Spain. FAU - Salas-Salvado, Jordi AU - Salas-Salvado J AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: jordi.salas@urv.cat. FAU - Babio, Nancy AU - Babio N AD - Universitat Rovira i Virgili, Departament de Bioquimica i Biotecnologia, Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), Reus, Spain; Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: nancy.babio@urv.cat. LA - eng PT - Journal Article DEP - 20260923 PL - Netherlands TA - EBioMedicine JT - EBioMedicine JID - 101647039 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Cardiovascular Diseases/epidemiology/etiology/metabolism MH - *Metabolomics/methods MH - Spain/epidemiology MH - Cross-Sectional Studies MH - Child, Preschool MH - Male MH - Child MH - *Metabolome MH - *Fast Foods/adverse effects MH - Biomarkers MH - Heart Disease Risk Factors MH - Risk Factors PMC - PMC13634276 OTO - NOTNLM OT - Cardiometabolic risk OT - Children OT - Metabolomics OT - Ultra-processed foods COIS- Declaration of interests JS-S reports non-financial support in the form of food products (virgin olive oil, almonds, and pistachios) provided by Patrimonio Comunal Olivarero, the Almond Board of California, and American Pistachio Growers, respectively, for pilot study participants. JS-S serves on the scientific advisory boards of the Danone Institute International and the International Nut and Dried Fruit Foundation on an unpaid basis. JS-S has received travel and accommodation support from the International Nut and Dried Fruit Foundation to attend scientific meetings and has participated as a member of the international advisory board of a research project on cashew nut supplementation in type 2 diabetes. Outside the submitted work, JS-S has received honoraria for lectures from the Danone Institute Spain and institutional grants or in-kind support from the International Nut and Dried Fruit Foundation. NVB reports an FPU grant from the Spanish Ministry of Science, Innovation and Universities (MCIU; FPU23/01950). All other authors declare no competing interests. EDAT- 2026/09/23 23:56 MHDA- 2026/10/14 23:31 PMCR- 2026/09/23 CRDT- 2026/09/23 18:02 PHST- 2026/02/23 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/08 00:00 [accepted] PHST- 2026/10/14 23:31 [medline] PHST- 2026/09/23 23:56 [pubmed] PHST- 2026/09/23 18:02 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - S2352-3964(26)00372-5 [pii] AID - 106488 [pii] AID - 10.1016/j.ebiom.2026.106488 [doi] PST - ppublish SO - EBioMedicine. 2026 Oct;132:106488. doi: 10.1016/j.ebiom.2026.106488. Epub 2026 Sep 23. PMID- 42777198 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260923 IS - 2791-6421 (Electronic) IS - 0041-4301 (Linking) VI - 68 IP - 4 DP - 2026 Sep 11 TI - Esophageal atresia and nutritional outcomes: the influence of anastomotic stricture and gastroesophageal reflux. PG - 662-671 LID - 10.24953/turkjpediatr.2026.6347 [doi] AB - BACKGROUND: Esophageal atresia (EA) is a congenital malformation often associated with long-term gastrointestinal complications and impaired growth. This study aimed to evaluate anthropometric outcomes in children with EA, with particular attention to the impact of associated conditions such as anastomotic stricture and gastroesophageal reflux (GER). METHODS: We conducted a retrospective analysis of patients with type C EA who underwent primary anastomosis between 2005 and 2021. Anthropometric data were collected at four age intervals (<1 year, 1-4 years, 5-11 years, >11 years) and standardized using validated growth charts. Associations between anthropometric parameters and the presence of stricture or GER were analyzed. RESULTS: Fifty-seven patients met the inclusion criteria. Stricture and GER were identified in 32% and 30% of patients, respectively. Infants (<1 year) with stricture had significantly lower BMI Z-scores -2.5 +/- 0.7 than those without stricture (-1.1 +/- 1.1; p=0.0093), while those with GER had significantly lower weight Z-scores (-2.1 +/- 1.0) than those without GER (-1.2 +/- 1.1; p=0.0443). Although most patients showed improvement in anthropometric parameters with age, early growth impairment was consistently observed in association with these complications. CONCLUSIONS: Children with EA are at risk of impaired growth during early childhood, particularly when stricture or GER is present. Regular anthropometric monitoring and early nutritional intervention are crucial, especially within the first year of life. Long-term multidisciplinary follow-up is recommended to optimize developmental outcomes. FAU - Salcedo Arroyo, Paula AU - Salcedo Arroyo P AUID- ORCID: 0000-0003-2579-2094 AD - Department of Pediatrics, Hospital Consorci Sanitari de Terrassa, Terrassa, Spain. AD - Department of Pediatrics, Hospital Universitari Mutua de Terrassa, Terrassa, Spain. FAU - Bragagnini Rodriguez, Paolo AU - Bragagnini Rodriguez P AUID- ORCID: 0000-0002-3053-3436 AD - Pediatric Surgery Department, Pediatric Surgery Research Group GIISA 018, Hospital Universitario Miguel Servet, Zaragoza, Spain. FAU - Fernandez Atuan, Rafael AU - Fernandez Atuan R AUID- ORCID: 0000-0002-3204-0483 AD - Pediatric Surgery Department, Pediatric Surgery Research Group GIISA 018, Hospital Universitario Miguel Servet, Zaragoza, Spain. AD - University of Zaragoza, Zaragoza, Spain. FAU - Garcia Romero, Ruth AU - Garcia Romero R AUID- ORCID: 0000-0002-3017-1340 AD - Department of Pediatric Gastroenterology, Hospital Universitario Miguel Servet, Zaragoza, Spain. FAU - Vargova, Paulina AU - Vargova P AUID- ORCID: 0000-0002-0705-5309 AD - Pediatric Surgery Department, Pediatric Surgery Research Group GIISA 018, Hospital Universitario Miguel Servet, Zaragoza, Spain. FAU - Ros Arnal, Ignacio AU - Ros Arnal I AUID- ORCID: 0000-0003-4163-8003 AD - Department of Pediatric Gastroenterology, Hospital Universitario Miguel Servet, Zaragoza, Spain. FAU - Corona Bellostas, Carolina AU - Corona Bellostas C AUID- ORCID: 0000-0002-7368-1033 AD - Pediatric Surgery Department, Pediatric Surgery Research Group GIISA 018, Hospital Universitario Miguel Servet, Zaragoza, Spain. AD - University of Zaragoza, Zaragoza, Spain. LA - eng PT - Journal Article DEP - 20260911 PL - Turkey TA - Turk J Pediatr JT - The Turkish journal of pediatrics JID - 0417505 SB - IM MH - Humans MH - *Esophageal Atresia/surgery/complications MH - *Gastroesophageal Reflux/complications/etiology MH - Retrospective Studies MH - Female MH - Male MH - Infant MH - Child MH - Child, Preschool MH - *Esophageal Stenosis/etiology MH - Anastomosis, Surgical/adverse effects MH - *Postoperative Complications MH - *Nutritional Status OTO - NOTNLM OT - esophageal atresia OT - esophageal stricture OT - gastroesophageal reflux OT - growth OT - nutritional status EDAT- 2026/09/23 17:37 MHDA- 2026/09/23 23:56 CRDT- 2026/09/23 16:06 PHST- 2025/05/23 00:00 [received] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/09/23 23:56 [medline] PHST- 2026/09/23 17:37 [pubmed] PHST- 2026/09/23 16:06 [entrez] AID - 6347 [pii] AID - 10.24953/turkjpediatr.2026.6347 [doi] PST - epublish SO - Turk J Pediatr. 2026 Sep 11;68(4):662-671. doi: 10.24953/turkjpediatr.2026.6347. PMID- 42776987 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260925 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 9 DP - 2026 TI - Acceptability, feasibility, appropriateness, uptake and cost perceptions of family mid-upper arm circumference supported by two-way SMS in western Kenya. PG - e0358775 LID - 10.1371/journal.pone.0358775 [doi] LID - e0358775 AB - Early identification and treatment of acute malnutrition can decrease mortality and morbidity related to wasting or low weight-for-height. Teaching caregivers to measure mid-upper arm circumference (MUAC), an approach known as Family MUAC, may support early diagnosis of wasting. Family MUAC paired with mobile support from healthcare workers resulted in a 37% reduction in child wasting in the Mama Aweza trial in Kenya. This study examines the intervention's acceptability, feasibility, appropriateness, uptake, perceptions of cost savings, and factors influencing engagement with Family MUAC. This qualitative study involved eight focus group discussions with caregivers enrolled in the Mama Aweza trial and fourteen in-depth interviews with caregivers who participated in the intervention arm, Family MUAC supported by two-way short message service (SMS). Caregivers were purposively selected based on engagement level with the intervention. Eighteen program staff and healthcare workers from three facilities in western Kenya participated in in-depth interviews. The Theoretical Domains Framework informed design of data collection tools. Caregiver and healthcare worker perceptions of Family MUAC with two-way SMS centered on seven themes. The intervention was viewed as acceptable, cost-saving, appropriate, feasible, and empowering. Caregiver uptake was high, and integrating child growth monitoring with other health services may help enhance sustainability. Barriers to uptake included inconsistent MUAC measurements, limited social support, and issues with phone sharing. Refresher trainings could increase accuracy of MUAC measurements and improve engagement. Direct communication with healthcare workers via SMS built trust and strengthened patient-provider relationships. Caregivers also reported perceived cost savings, as SMS communication reduced unnecessary travel to health centers when children were not malnourished. This study supports Family MUAC with two-way SMS as a promising approach to empower caregivers and highlights their critical role in child health and nutrition interventions. Future interventions can focus on improving measurement accuracy and mitigating negative social influences on caregiver-led interventions. CI - Copyright: (c) 2026 Choo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Choo, Esther M AU - Choo EM AUID- ORCID: 0000-0001-6564-7962 AD - Department of Global Health, University of Washington, Seattle, Washington, United States of America. FAU - Lara-Arevalo, Jonathan AU - Lara-Arevalo J AUID- ORCID: 0000-0001-9588-7027 AD - Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. FAU - Achieng, Catherine AU - Achieng C AD - Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya. FAU - Odhiambo, Merceline AU - Odhiambo M AD - Independent Consultant, Nairobi, Kenya. FAU - Okello, Maurine Anyango AU - Okello MA AD - Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya. FAU - Masheti, Mary AU - Masheti M AD - Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya. FAU - Tickell, Kirkby D AU - Tickell KD AD - Department of Global Health, University of Washington, Seattle, Washington, United States of America. FAU - Diakhate, Mame M AU - Diakhate MM AD - Department of Global Health, University of Washington, Seattle, Washington, United States of America. FAU - Singa, Benson O AU - Singa BO AD - Centre for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya. FAU - McGrath, Christine J AU - McGrath CJ AD - Department of Global Health, University of Washington, Seattle, Washington, United States of America. FAU - Means, Arianna Rubin AU - Means AR AUID- ORCID: 0000-0002-4087-7080 AD - Department of Global Health, University of Washington, Seattle, Washington, United States of America. LA - eng PT - Journal Article DEP - 20260923 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Kenya MH - *Arm/anatomy & histology MH - Female MH - Male MH - *Text Messaging MH - Caregivers/psychology MH - Feasibility Studies MH - Adult MH - Infant MH - Focus Groups MH - Child, Preschool MH - Health Personnel PMC - PMC13600513 COIS- The authors have declared that no competing interests exist. EDAT- 2026/09/23 17:36 MHDA- 2026/09/23 17:37 PMCR- 2026/09/23 CRDT- 2026/09/23 13:44 PHST- 2025/12/17 00:00 [received] PHST- 2026/09/06 00:00 [accepted] PHST- 2026/09/23 17:37 [medline] PHST- 2026/09/23 17:36 [pubmed] PHST- 2026/09/23 13:44 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - PONE-D-25-63080 [pii] AID - 10.1371/journal.pone.0358775 [doi] PST - epublish SO - PLoS One. 2026 Sep 23;21(9):e0358775. doi: 10.1371/journal.pone.0358775. eCollection 2026. PMID- 42776291 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20261008 IS - 1534-312X (Electronic) IS - 1522-8037 (Linking) VI - 28 IP - 1 DP - 2026 Sep 23 TI - Small Intestinal Bacterial Overgrowth in the Pediatric Population: A Review of Pathophysiology, Diagnosis, and Management. LID - 32 [pii] LID - 10.1007/s11894-026-01059-w [doi] AB - PURPOSE OF REVIEW: Small intestinal bacterial overgrowth (SIBO) remains a significant diagnostic and therapeutic challenge in pediatric gastroenterology. This review summarizes the epidemiology, pathophysiology, diagnosis, and management of SIBO in children, with emphasis on recent advances in microbiome science, evolving diagnostic paradigms, and pediatric-specific clinical considerations. RECENT FINDINGS: SIBO is increasingly recognized across a broad range of pediatric conditions, including intestinal failure, motility disorders, disorders of gut-brain interaction, and systemic diseases associated with gastrointestinal dysmotility. Diagnosis remains challenging as currently available tests have important limitations and pediatric-specific diagnostic standards are lacking. Management requires a multifaceted approach that combines antimicrobial therapy, correction of underlying anatomic abnormalities or treatment of dysmotility, nutritional support, and emerging microbiome-directed strategies. Future research should focus on validating pediatric-specific diagnostic criteria, defining optimal treatment regimens, and advancing precision approaches to microbiome characterization and modulation. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Mody, Shaan AU - Mody S AUID- ORCID: 0009-0002-6989-7963 AD - Rowan-Virtua School of Osteopathic Medicine, Stratford, NJ, USA. FAU - Laxer, Alison AU - Laxer A AUID- ORCID: 0009-0001-9414-1706 AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center/NewYork-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. FAU - Gandhi, Jermie AU - Gandhi J AUID- ORCID: 0009-0008-6845-3395 AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Columbia University Irving Medical Center/NewYork-Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. jg4701@cumc.columbia.edu. LA - eng PT - Journal Article PT - Review DEP - 20260923 PL - United States TA - Curr Gastroenterol Rep JT - Current gastroenterology reports JID - 100888896 RN - 0 (Anti-Bacterial Agents) SB - IM MH - Humans MH - Child MH - *Intestine, Small/microbiology/physiopathology MH - Anti-Bacterial Agents/therapeutic use MH - *Blind Loop Syndrome/diagnosis/therapy/physiopathology MH - Gastrointestinal Microbiome OTO - NOTNLM OT - Antibiotic therapy OT - Breath test OT - Dysbiosis OT - Dysmotility OT - Short bowel syndrome OT - Small intestinal bacterial overgrowth (SIBO) COIS- Declarations. The authors did not receive support from any organization for the submitted work. Human and animal rights: This article does not contain any studies with human or animal subjects performed by any of the authors. Competing interests: The authors declare no competing interests. EDAT- 2026/09/23 17:36 MHDA- 2026/09/23 17:37 CRDT- 2026/09/23 11:16 PHST- 2026/07/29 00:00 [received] PHST- 2026/09/20 00:00 [accepted] PHST- 2026/09/23 17:37 [medline] PHST- 2026/09/23 17:36 [pubmed] PHST- 2026/09/23 11:16 [entrez] AID - 10.1007/s11894-026-01059-w [pii] AID - 10.1007/s11894-026-01059-w [doi] PST - epublish SO - Curr Gastroenterol Rep. 2026 Sep 23;28(1):32. doi: 10.1007/s11894-026-01059-w. PMID- 42776278 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20261001 IS - 1432-1335 (Electronic) IS - 0171-5216 (Print) IS - 0171-5216 (Linking) VI - 152 IP - 9 DP - 2026 Sep 22 TI - Sleep quality and disturbances in adolescents and young adults with cancer compared to a healthy comparison group: results of the AYA-LE study. LID - 10.1007/s00432-026-06627-1 [doi] LID - 185 AB - PURPOSE: Adolescents and young adults (AYAs) with cancer often exhibit riskier health behaviors, including poorer sleep patterns, compared to older individuals. Research on the relationship between cancer and sleep quality in AYA patients has yielded inconsistent results. This study investigates sleep quality in AYA patients compared to a healthy comparison group and examines associated sociodemographic, clinical, and psychosocial variables as well as physical activity. METHODS: The prospective observational study included 407 AYA patients aged 18-39 years at diagnosis and 372 healthy participants aged 18-45 years, with data collected from May-September 2019. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). Validated questionnaires measured self-efficacy, social support, anxiety, depression, quality of life, lack of energy, and physical activity. Multiple regression analyses were employed to explore the variables associated with sleep quality. RESULTS: The mean age of the AYA patients was 34.8 years (75.2% women) and 32.3 years of the healthy participants (61.8% women). AYA patients demonstrated significantly poorer subjective sleep quality (d=0.31), lower sleep efficiency (d=0.15), more frequent sleep disturbances (d=0.23), greater use of sleep medication (d=0.25), and higher daytime dysfunction (d=0.29). Anxiety, depression (HADS), quality of life (EORTC), and unmet needs for support through lack of energy (SCNS) were significantly associated with PSQI (adjusted R(2)=0.35). CONCLUSION: These findings underscore the relevance of sleep disturbances in AYA patients and support greater attention to sleep disturbances in survivorship care. Routine assessment of sleep quality may help identify AYA patients who could benefit from further evaluation and appropriate support. CI - (c) 2026. The Author(s). FAU - Wieland, Carolin AU - Wieland C AUID- ORCID: 0009-0007-2507-5294 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. FAU - Friedrich, Michael AU - Friedrich M AUID- ORCID: 0000-0002-0528-1564 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. FAU - Sender, Annekathrin AU - Sender A AUID- ORCID: 0000-0002-5457-4021 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. FAU - Leuteritz, Katja AU - Leuteritz K AUID- ORCID: 0000-0002-5942-0988 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. FAU - Brock, Hannah AU - Brock H AUID- ORCID: 0000-0002-9905-9488 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. FAU - Geue, Kristina AU - Geue K AUID- ORCID: 0000-0001-6590-5650 AD - University Clinic for Psychosomatic Medicine and Psychotherapy, University Medical Center Magdeburg, Otto-von-Guericke Universitat Magdeburg, Magdeburg, Germany. FAU - Mehnert-Theuerkauf, Anja AU - Mehnert-Theuerkauf A AUID- ORCID: 0000-0002-6872-9805 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. FAU - Richter, Diana AU - Richter D AUID- ORCID: 0000-0003-3977-2801 AD - Department of Medical Psychology and Medical Sociology, Comprehensive Cancer Center Central Germany (CCCG), University Medical Center Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Germany. diana.richter@medizin.uni-leipzig.de. LA - eng PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20260922 PL - Germany TA - J Cancer Res Clin Oncol JT - Journal of cancer research and clinical oncology JID - 7902060 SB - IM MH - Humans MH - Female MH - Adult MH - Young Adult MH - Adolescent MH - *Neoplasms/complications/psychology/physiopathology MH - *Sleep Quality MH - Male MH - *Sleep Wake Disorders/etiology/epidemiology MH - Prospective Studies MH - Quality of Life MH - Surveys and Questionnaires MH - Middle Aged MH - Case-Control Studies MH - Depression PMC - PMC13601403 OTO - NOTNLM OT - AYA OT - Cancer OT - PSQI OT - Psycho-oncology OT - Sleep OT - Survivorship COIS- Declarations. Conflict of interest: The authors declare no conflict of interest. EDAT- 2026/09/23 17:36 MHDA- 2026/09/23 17:37 PMCR- 2026/09/22 CRDT- 2026/09/23 11:14 PHST- 2026/08/11 00:00 [received] PHST- 2026/09/15 00:00 [accepted] PHST- 2026/09/23 17:37 [medline] PHST- 2026/09/23 17:36 [pubmed] PHST- 2026/09/23 11:14 [entrez] PHST- 2026/09/22 00:00 [pmc-release] AID - 10.1007/s00432-026-06627-1 [pii] AID - 6627 [pii] AID - 10.1007/s00432-026-06627-1 [doi] PST - epublish SO - J Cancer Res Clin Oncol. 2026 Sep 22;152(9):185. doi: 10.1007/s00432-026-06627-1. PMID- 42776237 OWN - NLM STAT- Publisher LR - 20260923 IS - 1432-1971 (Electronic) IS - 0172-0643 (Linking) DP - 2026 Sep 23 TI - The Fontan Choir: Singing for Single Ventricle Health and Wellbeing Feasibility Study. LID - 10.1007/s00246-026-04483-x [doi] AB - Children with Fontan circulation (FC) rely on passive blood flow to the lungs and require optimal lung function [1, 2]. Singing has been shown to increase exercise capacity, improve lung function and enhance quality of life (QoL) in adults and in rare studies of children with non-cardiac disease [7-9]. Singing as an intervention has not been studied in children with FC. A feasibility program of in-person and online singing and breathing instruction was developed and trialed by the Bienen School of Music and the Heart Center of the Ann & Robert H. Lurie Children's Hospital of Chicago. Pre- and post-intervention measures of exercise capacity, respiratory muscle strength, and QoL assessments were conducted before and after 8 weeks of singing instruction. This study provided 30 min of private voice instruction and 60 min of group instruction/week for eight weeks. In-person instruction was supported by an asynchronous on-line program of singing and breathing exercises performed independently several days per week between in-person sessions. The program was safe and feasible. 14 children aged 8-16 years completed the study with an 89% attendance rate and 27.5% homework completion rate. Post-intervention assessments demonstrated improvements in 3 breathing measures (single breath counting, sustained ah, and Twinkle Twinkle task) p < 0.005. Improvements occurred in patient self-report of depression (p < 0.05) and parent proxy reports of school function (p = 0.04), depression (p = 0.03) and anxiety (p = 0.02) and patient wellbeing p < 0.01. There was no improvement in spirometry or 6MWT. The program was well received by both children and parents. Our findings support the feasibility and acceptability of singing as an adjunct intervention for FC patients. Further investigation of these findings in a larger, longer trial is warranted. CI - (c) 2026. The Author(s). FAU - Ward, Kendra M AU - Ward KM AUID- ORCID: 0009-0009-0012-7750 AD - The Ann & Robert H. Lurie Children's Hospital of Chicago, Pediatrics, Chicago, IL, USA. kward@luriechildrens.org. AD - Northwestern University Feinberg School of Medicine, Pediatrics, Chicago, IL, USA. kward@luriechildrens.org. FAU - Bartolome, Sarah J AU - Bartolome SJ AUID- ORCID: 0000-0003-1469-3883 AD - Northwestern University Henry and Leigh Bienen School of Music, Evanston, IL, USA. FAU - Steltzer, Michelle M AU - Steltzer MM AD - The Ann & Robert H. Lurie Children's Hospital of Chicago, Pediatrics, Chicago, IL, USA. FAU - Snyder, Amanda AU - Snyder A AD - The Ann & Robert H. Lurie Children's Hospital of Chicago, Pediatrics, Chicago, IL, USA. FAU - Gregoire, Stephanie J AU - Gregoire SJ AUID- ORCID: 0009-0007-3425-6724 AD - University of Illinois Chicago School of Theatre and Music, Music Education, Chicago, IL, USA. FAU - Vogel, Casey AU - Vogel C AUID- ORCID: 0009-0004-5328-1800 AD - The Ann & Robert H. Lurie Children's Hospital of Chicago, Pediatrics, Chicago, IL, USA. FAU - McNulty, Devin C AU - McNulty DC AUID- ORCID: 0000-0002-9127-5688 AD - The Ann & Robert H. Lurie Children's Hospital of Chicago, Pediatrics, Chicago, IL, USA. FAU - Gustafson, Nancy J AU - Gustafson NJ AD - Northwestern University Henry and Leigh Bienen School of Music, Evanston, IL, USA. FAU - Brancaccio, Theresa A AU - Brancaccio TA AD - Northwestern University Henry and Leigh Bienen School of Music, Evanston, IL, USA. FAU - Allen, Kiona Y AU - Allen KY AD - The Ann & Robert H. Lurie Children's Hospital of Chicago, Pediatrics, Chicago, IL, USA. AD - Northwestern University Feinberg School of Medicine, Pediatrics, Chicago, IL, USA. FAU - Loomba, Rohit AU - Loomba R AD - The Ann & Robert H. Lurie Children's Hospital of Chicago, Pediatrics, Chicago, IL, USA. AD - Northwestern University Feinberg School of Medicine, Pediatrics, Chicago, IL, USA. FAU - Miller, Jodi AU - Miller J AUID- ORCID: 0009-0005-9329-4400 AD - Johns Hopkins University School of Education, Baltimore, MD, USA. FAU - Pelech, Andrew AU - Pelech A AD - The Ann & Robert H. Lurie Children's Hospital of Chicago, Pediatrics, Chicago, IL, USA. AD - Northwestern University Feinberg School of Medicine, Pediatrics, Chicago, IL, USA. LA - eng PT - Journal Article DEP - 20260923 PL - United States TA - Pediatr Cardiol JT - Pediatric cardiology JID - 8003849 SB - IM OTO - NOTNLM OT - Fontan OT - Restrictive lung disease OT - Singing OT - Single ventricle COIS- Declarations. Competing Interests: The authors declare no competing interests. EDAT- 2026/09/23 17:36 MHDA- 2026/09/23 17:36 CRDT- 2026/09/23 11:12 PHST- 2026/07/01 00:00 [received] PHST- 2026/09/05 00:00 [accepted] PHST- 2026/09/23 17:36 [medline] PHST- 2026/09/23 17:36 [pubmed] PHST- 2026/09/23 11:12 [entrez] AID - 10.1007/s00246-026-04483-x [pii] AID - 10.1007/s00246-026-04483-x [doi] PST - aheadofprint SO - Pediatr Cardiol. 2026 Sep 23. doi: 10.1007/s00246-026-04483-x. PMID- 42776174 OWN - NLM STAT- Publisher LR - 20260923 IS - 1558-9110 (Electronic) IS - 1058-0360 (Linking) DP - 2026 Sep 23 TI - The Management of Swallowing Disorders in Children With Spinal Muscular Atrophy Type 1: A Scoping Review. PG - 1-22 LID - 10.1044/2026_AJSLP-25-00460 [doi] AB - PURPOSE: Spinal muscular atrophy Type 1 (SMA1) is a rare autosomal recessive neuromuscular disorder with progressive muscle weakness and atrophy. Dysphagia is common among children with SMA1, and its complications are frequently documented. This scoping review aimed to describe the management of swallowing disorders in this population. METHOD: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, four electronic databases were searched (PubMed, Embase, CINAHL, and Cochrane Library) for studies on children with SMA1. We investigated the management of swallowing disorders in children with SMA1, including methods and protocols used to assess swallowing and feeding, and treatment option. The quality of included studies was assessed using the Joanna Briggs Institute checklists; two independent researchers conducted study selection and data extraction. RESULTS: Thirty-eight studies with a total of 1,784 SMA1 patients were included. Swallowing was evaluated using instrumental methods (flexible endoscopic evaluation of swallowing and videofluoroscopic swallowing study) and clinical assessments, with one validated protocol identified for pediatric SMA (Oral and Swallowing Abilities Tool). Delayed initiation of swallowing, oral impairment, pharyngeal residues, and aspiration were frequently reported. Percutaneous endoscopic gastrostomy was used in cases of severe dysphagia, malnutrition, and failure to thrive. Few studies reported information on compensatory strategies and rehabilitative treatments. CONCLUSION: Further research is needed to standardize swallowing assessment approaches and to evaluate the effectiveness of rehabilitative and compensatory interventions in children with SMA1. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.33746656. FAU - Rocca, Sara AU - Rocca S AUID- ORCID: 0000-0002-4144-7269 AD - Department of Biomedical and Clinical Sciences, Universita degli Studi di Milano, Italy. FAU - Pizzi, Laura AU - Pizzi L AD - Department of Biomedical and Clinical Sciences, Universita degli Studi di Milano, Italy. FAU - Pizzorni, Nicole AU - Pizzorni N AD - Department of Biomedical and Clinical Sciences, Universita degli Studi di Milano, Italy. FAU - Gandolfi, Sofia AU - Gandolfi S AD - Developmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. FAU - Masson, Riccardo AU - Masson R AD - Developmental Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. FAU - Schindler, Antonio AU - Schindler A AD - Department of Biomedical and Clinical Sciences, Universita degli Studi di Milano, Italy. AD - Phoniatric and Speech and Language Pathology Unit, V. Buzzi Children Hospital, ASST Fatebenefratelli Sacco, Milan, Italy. LA - eng PT - Journal Article DEP - 20260923 PL - United States TA - Am J Speech Lang Pathol JT - American journal of speech-language pathology JID - 9114726 SB - IM EDAT- 2026/09/23 17:36 MHDA- 2026/09/23 17:36 CRDT- 2026/09/23 11:07 PHST- 2026/09/23 17:36 [medline] PHST- 2026/09/23 17:36 [pubmed] PHST- 2026/09/23 11:07 [entrez] AID - 10.1044/2026_AJSLP-25-00460 [doi] PST - aheadofprint SO - Am J Speech Lang Pathol. 2026 Sep 23:1-22. doi: 10.1044/2026_AJSLP-25-00460. PMID- 42775974 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260928 IS - 2164-2591 (Electronic) IS - 2164-2591 (Linking) VI - 15 IP - 9 DP - 2026 Sep 1 TI - Description and Evaluation of a Visual Acuity Assessment Paradigm Based on Spatial Frequency-Modulated Form Discrimination. PG - 15 LID - 10.1167/tvst.15.9.15 [doi] LID - 15 AB - PURPOSE: To describe and evaluate a visual acuity assessment paradigm based on spatial frequency-modulated form discrimination for induced and disease-driven vision loss. METHODS: The Patterned-Optotype-in-Noise Task (POINT) consisted of arrow-shaped random noise patterns, each with a 1/f2 amplitude spectrum overlaid on a low-pass filtered background. Stimulus difficulty varied logarithmically across 22 levels by adjusting the background cutoff spatial frequency, relative to foreground. Monocular acuity was measured for POINT stimuli and letter optotypes in 20 adults (21-46 years) with 0-4D of induced blur and in 50 patients (9-77 years) with vision impairment from ocular pathologies/uncorrected refractive error. RESULTS: The POINT demonstrated systematic loss in visual acuity with induced optical blur and eye pathologies, like the standard letter acuity test (P < 0.001). The losses with induced blur in the POINT followed standard Fourier optics predictions of spatial-frequency discrimination between the background and foreground pattern. The test-retest repeatability of POINT was also comparable to letter acuity testing (mean difference +/- 95% limits of agreement: +0.04 units +/- 0.2 units), but with limited agreement in the acuity measures obtained between the two tests. CONCLUSIONS: The POINT is a reliable technique for estimating visual acuity with induced and disease-driven vision loss. However, caution should be exercised when directly comparing these outcomes to standard letter acuity tests owing to fundamental differences in stimulus construction and task requirements. TRANSLATIONAL RELEVANCE: The POINT offers a physiologically and theoretically grounded complement to standard assessment of visual acuity in clinical, research and public eye health settings. FAU - Lansey, Jonathan AU - Lansey J AD - REACT Neuro, Inc., Cambridge, MA, USA. FAU - Sirivella, Indrani AU - Sirivella I AD - Prof. Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India. AD - Centre for Technology Innovation, L V Prasad Eye Institute, Hyderabad, India. FAU - Negi, Rahul AU - Negi R AD - Prof. Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India. AD - Centre for Technology Innovation, L V Prasad Eye Institute, Hyderabad, India. FAU - Patel, Shaun R AU - Patel SR AD - REACT Neuro, Inc., Cambridge, MA, USA. FAU - Bharadwaj, Shrikant R AU - Bharadwaj SR AD - Prof. Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India. AD - Centre for Technology Innovation, L V Prasad Eye Institute, Hyderabad, India. AD - Brien Holden Institute of Optometry and Vision Sciences, L V Prasad Eye Institute, Hyderabad, India. LA - eng PT - Journal Article PL - United States TA - Transl Vis Sci Technol JT - Translational vision science & technology JID - 101595919 SB - IM MH - Humans MH - *Visual Acuity/physiology MH - Middle Aged MH - *Vision Tests/methods MH - Adult MH - Female MH - Adolescent MH - Aged MH - Male MH - Child MH - Young Adult MH - Reproducibility of Results MH - *Form Perception/physiology MH - *Discrimination, Psychological/physiology MH - *Vision Disorders/physiopathology/diagnosis MH - Photic Stimulation/methods PMC - PMC13615559 COIS- Disclosure: J. Lansey, ReactNeuro (E); I. Sirivella, None; R. Negi, None; S.R. Patel, ReactNeuro (E); S.R. Bharadwaj, None EDAT- 2026/09/23 11:50 MHDA- 2026/09/23 11:51 PMCR- 2026/09/23 CRDT- 2026/09/23 09:33 PHST- 2026/09/23 11:51 [medline] PHST- 2026/09/23 11:50 [pubmed] PHST- 2026/09/23 09:33 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - 2818601 [pii] AID - TVST-26-9779 [pii] AID - 10.1167/tvst.15.9.15 [doi] PST - ppublish SO - Transl Vis Sci Technol. 2026 Sep 1;15(9):15. doi: 10.1167/tvst.15.9.15. PMID- 42775715 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260925 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 3 DP - 2026 Jul TI - Animal- and Plant-Source Protein-Rich Foods Differ in Their Association With Maternal Micronutrient Status and Breast Milk Composition During Lactation. PG - e70253 LID - 10.1111/mcn.70253 [doi] LID - e70253 AB - Micronutrient deficiencies in lactating women remain widespread and under-addressed, compromising maternal health and breast milk quality. Although dietary guidelines promote protein-rich foods, most do not distinguish between animal and plant sources within this food group, despite differences in nutrient profiles and bioavailability. This study examined associations between intake of animal-source and plant-source foods within the protein-rich food group and maternal nutritional biomarkers in blood and breast milk. Nutrient contributions from each source and intake patterns across sociodemographic groups were also assessed. Data were drawn from 220 mother-infant pairs in urban and rural West Java, Indonesia. Maternal dietary intake was assessed over 3 non-consecutive days using a combination of weighed food records and recall. At 5 months postpartum, maternal BMI, blood, and breast milk samples were collected to assess zinc, iron, vitamin A, and B12 status. Associations between dietary intake and maternal biomarkers were analysed using multiple linear regression, adjusting for relevant covariates. Total protein-rich food intake was not significantly associated with maternal biomarkers. However, higher intake of animal-source protein-rich foods was positively associated with serum B12 and zinc, while higher intake of plant-source protein-rich foods was inversely associated with breast milk vitamin A. Macronutrients, particularly protein and fat, from animal-based foods were more strongly associated with maternal micronutrient biomarkers than micronutrient intake alone. Protein-rich food intake did not vary across sociodemographic groups, indicating feasibility for broad-based interventions. These findings support a shift in dietary guidance for lactating women, from focusing solely on total quantity of protein-rich foods to recognising nutritionally meaningful differences between animal-source and plant-source foods. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Rahmannia, Sofa AU - Rahmannia S AUID- ORCID: 0000-0003-2988-1334 AD - School of Population and Global Health, The University of Western Australia, Crawley, Western Australia, Australia. AD - Faculty of Medicine, Universitas Pasundan, Bandung, West Java, Indonesia. FAU - Arena, Gina AU - Arena G AUID- ORCID: 0000-0002-6956-3472 AD - Medical School, The University of Western Australia, Nedlands, Western Australia, Australia. AD - The Kids Research Institute, Nedlands, Western Australia, Australia. FAU - Murray, Kevin AU - Murray K AUID- ORCID: 0000-0002-8856-6046 AD - School of Population and Global Health, The University of Western Australia, Crawley, Western Australia, Australia. FAU - Diana, Aly AU - Diana A AUID- ORCID: 0000-0002-9394-5235 AD - Nutrition Working Group, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia. AD - Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, West Java, Indonesia. FAU - Houghton, Lisa AU - Houghton L AUID- ORCID: 0000-0002-2276-6205 AD - Department of Human Nutrition, University of Otago, Dunedin, Otago, New Zealand. FAU - Gibson, Rosalind AU - Gibson R AUID- ORCID: 0000-0002-1738-7593 AD - Department of Human Nutrition, University of Otago, Dunedin, Otago, New Zealand. FAU - Hickling, Siobhan AU - Hickling S AUID- ORCID: 0000-0001-8337-2894 AD - School of Population and Global Health, The University of Western Australia, Crawley, Western Australia, Australia. LA - eng GR - OPP1127870/Bill and Melinda Gates Foundation/ GR - Australian Government Research Training Program/ PT - Journal Article PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 RN - 0 (Micronutrients) RN - 0 (Dietary Proteins) RN - 0 (Biomarkers) RN - J41CSQ7QDS (Zinc) RN - P6YC3EG204 (Vitamin B 12) RN - 11103-57-4 (Vitamin A) RN - 0 (Animal Proteins, Dietary) RN - 0 (Plant Proteins) SB - IM MH - Humans MH - Female MH - *Micronutrients/blood/deficiency/administration & dosage MH - *Lactation MH - Adult MH - *Nutritional Status MH - *Milk, Human/chemistry MH - *Dietary Proteins/administration & dosage MH - Indonesia MH - Animals MH - Biomarkers/blood MH - Zinc/blood MH - *Maternal Nutritional Physiological Phenomena MH - Vitamin B 12/blood MH - *Diet MH - Vitamin A/blood/analysis MH - *Animal Proteins, Dietary/administration & dosage MH - Young Adult MH - Body Mass Index MH - *Plant Proteins/administration & dosage PMC - PMC13599360 COIS- The authors declare no conflicts of interest. EDAT- 2026/09/23 11:50 MHDA- 2026/09/23 11:51 PMCR- 2026/09/23 CRDT- 2026/09/23 08:07 PHST- 2026/08/13 00:00 [revised] PHST- 2026/01/17 00:00 [received] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/09/23 11:51 [medline] PHST- 2026/09/23 11:50 [pubmed] PHST- 2026/09/23 08:07 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - MCN70253 [pii] AID - 10.1111/mcn.70253 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jul;22(3):e70253. doi: 10.1111/mcn.70253. PMID- 42775679 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20261016 IS - 1460-6984 (Electronic) IS - 1368-2822 (Print) IS - 1368-2822 (Linking) VI - 61 IP - 6 DP - 2026 Nov-Dec TI - Normative Data and Reliability of the Test of Masticating and Swallowing Solids (TOMASS) in Healthy Brazilian Adults. PG - e70328 LID - 10.1111/1460-6984.70328 [doi] LID - e70328 AB - INTRODUCTION: The Test of Masticating and Swallowing Solids (TOMASS) is a standardized clinical assessment designed to quantify oral phase swallowing efficiency during solid food intake. Although TOMASS has been investigated in several countries, normative data for the Brazilian population are still lacking. OBJECTIVE: To establish normative data and investigate the reliability of the Brazilian Portuguese version of TOMASS in healthy adults. METHODS: This observational cross-sectional study included 99 healthy adults stratified by age group. Individuals with dysphagia, head and neck cancer, neurological disorders, or gastrointestinal diseases were excluded. Participants underwent sociodemographic assessment, Montreal Cognitive Assessment (MoCA), oral structural evaluation, and TOMASS administration using a commercially available Cream Cracker biscuit available in Brazil. All assessments were video-recorded for subsequent analysis. Test-retest reliability was assessed through repeated administrations of TOMASS, and inter-rater reliability was analysed using video recordings. The analysed variables included the number of bites, the number of masticatory cycles, the number of swallows, and total ingestion time. Statistical analyses included Student's t-test, ANOVA with Bonferroni post hoc tests, Wilcoxon test, and ICC coefficient. RESULTS: The sample included 99 healthy adults distributed across three age groups, with 54% women, a mean age of 50.2 (+/-16.3) years, mean education level of 12.4 (+/-4.1) years, and monthly household income equivalent to approximately two minimum wages (US$478 +/- US$228). Significant differences were found between age groups in the number of masticatory cycles (p = 0.021), specifically between the 20-40 and 61+ age groups (p = 0.040). Significant differences were also observed in total task time (p < 0.001), with contrasts between the 20-40 and 61+ groups (p = 0.002), as well as between the 41-60 and 61+ groups (p = 0.013). Test-retest reliability ranged from moderate to excellent, and inter-rater reliability demonstrated good to excellent agreement across TOMASS variables. CONCLUSION: The Brazilian Portuguese version of TOMASS demonstrated satisfactory reliability and applicability for assessing mastication and swallowing performance in healthy Brazilian adults. The present study also provides normative reference data that may support future clinical and research applications of TOMASS in Brazil. WHAT THIS PAPER ADDS: What is already known on the subject The quantitative variables obtained through the TOMASS protocol contribute to the diagnostic accuracy of mastication abilities during a clinical swallowing examination (CSE), supporting more precise clinical decision-making, particularly when compared with previously established normative values. Moreover, the quantitative data allow for monitoring biomechanical changes over time, whether due to natural processes such as aging, neurofunctional maturation, or spontaneous recovery, or attributed to the efficacy of specific therapeutic interventions. What this paper adds to existing knowledge Normative TOMASS data for the Brazilian population may serve as clinical guidelines for assessing chewing and swallowing functions, given that the test is easily integrated into clinical evaluations due to its low cost and quick administration. These data may be especially relevant in contexts where socioeconomic, cultural, and physical barriers, a reality for a significant portion of the Brazilian population, still limit access to healthcare. What are the potential or actual clinical implications of this study? The clinical implications of this study are significant for speech-language pathologists in Brazil and other professionals involved in swallowing assessment and rehabilitation. The establishment of normative TOMASS data for the Brazilian population provides a valuable reference for identifying deviations in mastication performance across age and gender groups. Moreover, in low-resource contexts and developing countries, a brief, easy-to-administer, and low-cost protocol such as TOMASS is especially valuable, enabling equitable access to standardized assessment and monitoring of masticatory and swallowing functions. CI - (c) 2026 The Author(s). International Journal of Language & Communication Disorders published by John Wiley & Sons Ltd on behalf of Royal College of Speech and Language Therapists. FAU - Arcaro, Maria Eduarda Soares AU - Arcaro MES AUID- ORCID: 0000-0002-5321-7671 AD - Postgraduate Program in Medical Science, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. FAU - Bressanelli, Amanda AU - Bressanelli A AUID- ORCID: 0000-0002-5056-5574 AD - Postgraduate Program in Medical Science, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. FAU - Santos, Vanessa Brzoskowski do AU - Santos VBD AUID- ORCID: 0000-0002-2322-3499 AD - Postgraduate Program in Medical Science, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. FAU - Barbosa, Alice AU - Barbosa A AUID- ORCID: 0009-0004-0303-6591 AD - Undergraduate Program in Speech-Language Pathology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. FAU - Bice, Ed AU - Bice E AUID- ORCID: 0000-0002-5753-9133 AD - IOPI Medical, LLC, Woodinville, Washington, USA. FAU - Olchik, Maira Rozenfeld AU - Olchik MR AUID- ORCID: 0000-0002-8732-9225 AD - Postgraduate Program in Medical Science, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. AD - Undergraduate Program in Speech-Language Pathology, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Rio Grande do Sul, Brazil. AD - Neurology Service, Hospital de Clinicas de Porto Alegre (HCPA), Porto Alegre, Rio Grande do Sul, Brazil. LA - eng PT - Journal Article PT - Observational Study PL - United States TA - Int J Lang Commun Disord JT - International journal of language & communication disorders JID - 9803709 SB - IM MH - Humans MH - Female MH - Male MH - Middle Aged MH - Adult MH - Brazil MH - Reproducibility of Results MH - *Deglutition/physiology MH - Cross-Sectional Studies MH - Reference Values MH - *Mastication/physiology MH - Young Adult MH - Aged MH - Adolescent PMC - PMC13599047 OTO - NOTNLM OT - TOMASS OT - assessment OT - deglutition OT - mastication OT - solid OT - swallowing COIS- The authors declare no conflicts of interest. EDAT- 2026/09/23 11:50 MHDA- 2026/09/23 11:51 PMCR- 2026/09/23 CRDT- 2026/09/23 08:03 PHST- 2026/06/05 00:00 [revised] PHST- 2025/11/11 00:00 [received] PHST- 2026/08/20 00:00 [accepted] PHST- 2026/09/23 11:51 [medline] PHST- 2026/09/23 11:50 [pubmed] PHST- 2026/09/23 08:03 [entrez] PHST- 2026/09/23 00:00 [pmc-release] AID - JLCD70328 [pii] AID - 10.1111/1460-6984.70328 [doi] PST - ppublish SO - Int J Lang Commun Disord. 2026 Nov-Dec;61(6):e70328. doi: 10.1111/1460-6984.70328. PMID- 42774817 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260923 LR - 20260924 IS - 1728-869X (Print) IS - 2226-5104 (Electronic) IS - 1728-869X (Linking) VI - 24 IP - 4 DP - 2026 Oct TI - Reliability and validity of the International FItness Scale (IFIS): A systematic review and meta-analysis. PG - 200501 LID - 10.1016/j.jesf.2026.200501 [doi] LID - 200501 AB - BACKGROUND: Reliable and valid physical fitness instruments are necessary for population-level surveillance and monitoring. However, lab-based and field-based measures are often impractical in large-scale studies. Self-rated fitness scales such as the International Fitness Scale (IFIS) offer a feasible alternative. Therefore, the aim of this review was to quantitatively synthesize the available evidence on the reliability and validity of the IFIS. METHOD: Four online databases (Ovid MEDLINE, SPORTDiscus, EMBASE and PubMed) were searched for papers published prior was performed August 2025. Studies meeting the following criteria were included: (1) published in English, (2) investigated the validity or reliability of the IFIS, (3) no limitation for population subgroups of the included studies. The risk of bias was assessed through the latest version of the COSMIN (Consensus-based Standards for the selection of health Measurement Instruments) Risk of Bias checklist. The random effects model was employed to compute the pooled effect sizes, the heterogeneity of the average effect size was assessed using I(2) statistic and Q statistics. RESULTS: After title and abstract screening, 20 records were assessed for full-text eligibility. Of these, 13 eligible studies (9634 participants) were included in this study. Reliability was assessed in 10 studies, and construct validity was assessed in a total of 11 studies (3 assessed the criterion validity). A substantial test-retest reliability was observed for overall fitness (pooled weighted kappa = 0.750, 95%CI = 0.600-0.848, Q = 899.283, I (2)  = 98.777), cardiorespiratory fitness (pooled weighted kappa = 0.752, 95%CI = 0.612-0.846, Q = 816.758, I (2)  = 98.653%), muscular fitness (pooled weighted kappa = 0.724, 95%CI = 0.630-0.798, Q = 350.584, I (2)  = 96.862%), speed-agility (pooled weighted kappa = 0.764, 95%CI = 0.645-0.847, Q = 655.508, I (2)  = 98.322%), and flexibility (pooled weighted kappa = 0.725, 95%CI = 0.633-0.796, Q = 335.094, I (2)  = 96.717%). The 11studies assessing the construct validity of the IFIS reported that participants who self-rated higher fitness with IFIS had higher objectively measured fitness, but due to different methods used, these results could not be meta-analyzed. CONCLUSIONS: This study shows that the IFIS is a reliable instrument to assess physical fitness in children and adolescents. Acceptable validity was reported across studies, yet could not be meta-analyzed due to diversity in methodologies. More studies are needed to discern its cultural adaptation among different population groups. CI - (c) 2026 The Society of Chinese Scholars on Exercise Physiology and Fitness. Published by Elsevier B.V. FAU - Bao, Ran AU - Bao R AD - College of Physical Education, Shanghai University, Shanghai, China. FAU - Zhang, Yanjie AU - Zhang Y AD - School of Humanities and Social Science, The Chinese University of Hong Kong-Shenzhen, Shenzhen, China. FAU - Ortega, Francisco B AU - Ortega FB AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. AD - CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain. FAU - Drenowatz, Clemens AU - Drenowatz C AD - Division of Sport, Physical Activity and Health, University of Education Upper Austria, Austria. FAU - Zhang, Kai AU - Zhang K AD - Healthy Activity Living and Obesity (HALO) Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, K1H 8L1, Canada. AD - School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, K1N 6N5, Canada. FAU - Chen, Sitong AU - Chen S AD - The Shenzhen Humanities & Social Sciences Key Research Bases of the Center for Mental Health, Shenzhen University, Shenzhen, 518060, China. LA - eng PT - Journal Article PT - Review DEP - 20260728 PL - Singapore TA - J Exerc Sci Fit JT - Journal of exercise science and fitness JID - 101198241 PMC - PMC13594616 OTO - NOTNLM OT - IFIS OT - Meta-analysis OT - Reliability OT - Systematic review OT - Validity COIS- The authors declare no conflicts of interest. EDAT- 2026/09/23 11:50 MHDA- 2026/09/23 11:51 PMCR- 2026/07/28 CRDT- 2026/09/23 06:51 PHST- 2025/12/22 00:00 [received] PHST- 2026/07/26 00:00 [revised] PHST- 2026/07/26 00:00 [accepted] PHST- 2026/09/23 11:51 [medline] PHST- 2026/09/23 11:50 [pubmed] PHST- 2026/09/23 06:51 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - S1728-869X(26)00062-6 [pii] AID - 200501 [pii] AID - 10.1016/j.jesf.2026.200501 [doi] PST - ppublish SO - J Exerc Sci Fit. 2026 Oct;24(4):200501. doi: 10.1016/j.jesf.2026.200501. Epub 2026 Jul 28. PMID- 42774383 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260924 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Nutritional determinants, childhood morbidity patterns, and healthcare utilization among Chinese children: a population-based study. PG - 1909080 LID - 10.3389/fpubh.2026.1909080 [doi] LID - 1909080 AB - BACKGROUND: Childhood nutrition has a substantial impact on growth, disease susceptibility, and use of health care services. Malnutrition is a double burden in China, characterized by chronic undernutrition and childhood obesity. OBJECTIVE: The objective of this study was to explore the relationships between nutrition determinants, childhood morbidity patterns and health care utilization in the Chinese population. METHODOLOGY: This retrospective, institution-based study analyzed routinely collected health records from 720 children aged 3-14 years who received care at a tertiary healthcare center in Nanchong, Sichuan, China, between 2021 and 2025. Nutritional status and dietary quality were determined by using the routine health records. Morbidity burden and service use were assessed using medical records for children. Independent predictors were identified by using multivariable logistic regression. RESULTS: 15.1% of participants were undernourished, and 20.3% were overweight or obese. The childhood morbidity burden was observed in 25.7% of children and was significantly higher in children who were undernourished and obese (p < 0.001). Known-groups validity testing showed that all 9 individual components of the dietary-quality score varied significantly and monotonically across derived tiers (Cochran-Armitage p < 0.001 for all), supporting the internal coherence of the measure. Poor dietary quality, as measured by this study-specific composite index, was an independent risk factor for a high burden of morbidity (Adjusted odds ratio (AOR) = 2.76, 95% CI: 1.89-4.05). High healthcare utilization was observed in 25.8% of participants. It was independently associated with high morbidity burden (AOR = 3.87, 95% CI: 2.71-5.54), undernutrition (AOR = 2.09, 95% CI: 1.37-3.20), obesity (AOR = 2.34, 95% CI: 1.40-3.89), poor dietary quality (AOR = 1.96, 95% CI: 1.32-2.92), low household income (AOR = 1.58, 95% CI: 1.07-2.34), and grandparent caregiving (AOR = 1.45, 95% CI: 1.01-2.11). CONCLUSION: Undernutrition and overweight/obesity, in addition to poor diet quality, are associated with higher morbidity rates and utilization of health services in children in China. The findings suggest that nutritional status and dietary quality are significantly associated with childhood morbidity burden and healthcare utilization. CI - Copyright (c) 2026 Wang, Liao, Zhang, Zhao, Zhang and Huang. FAU - Wang, Pengli AU - Wang P AD - Department of Pediatric Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical School of North Sichuan Medical University, Nanchong, Sichuan, China. FAU - Liao, Wenhua AU - Liao W AD - Department of Pediatric Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical School of North Sichuan Medical University, Nanchong, Sichuan, China. FAU - Zhang, Li AU - Zhang L AD - Department of Pediatric Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical School of North Sichuan Medical University, Nanchong, Sichuan, China. FAU - Zhao, Mingjia AU - Zhao M AD - Department of Pediatric Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical School of North Sichuan Medical University, Nanchong, Sichuan, China. FAU - Zhang, Dong AU - Zhang D AD - Department of Pediatric Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical School of North Sichuan Medical University, Nanchong, Sichuan, China. FAU - Huang, Nanxiang AU - Huang N AD - Department of Pediatric Surgery, Beijing Anzhen Nanchong Hospital, Capital Medical University and Nanchong Central Hospital, The Second Clinical Medical School of North Sichuan Medical University, Nanchong, Sichuan, China. LA - eng PT - Journal Article DEP - 20260908 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Chinese people SB - IM MH - Humans MH - Female MH - China/epidemiology MH - Child, Preschool MH - Child MH - Retrospective Studies MH - Male MH - *Patient Acceptance of Health Care/statistics & numerical data MH - Adolescent MH - *Nutritional Status MH - Morbidity MH - Malnutrition/epidemiology MH - *Pediatric Obesity/epidemiology MH - East Asian People PMC - PMC13593838 OTO - NOTNLM OT - Chinese children OT - childhood nutrition OT - dietary quality OT - healthcare utilization OT - malnutrition OT - morbidity burden COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/23 11:50 MHDA- 2026/09/23 11:51 PMCR- 2026/09/08 CRDT- 2026/09/23 06:13 PHST- 2026/06/14 00:00 [received] PHST- 2026/08/06 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/23 11:51 [medline] PHST- 2026/09/23 11:50 [pubmed] PHST- 2026/09/23 06:13 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1909080 [doi] PST - epublish SO - Front Public Health. 2026 Sep 8;14:1909080. doi: 10.3389/fpubh.2026.1909080. eCollection 2026. PMID- 42774326 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260923 LR - 20260924 IS - 1663-9812 (Print) IS - 1663-9812 (Electronic) IS - 1663-9812 (Linking) VI - 17 DP - 2026 TI - Cloning of a novel cyanobacterial serotonin N-acetyltransferase gene CySNAT3 and its integration with transcriptomic drug repurposing in pediatric obstructive sleep-disordered breathing. PG - 1851793 LID - 10.3389/fphar.2026.1851793 [doi] LID - 1851793 AB - BACKGROUND: Melatonin has potential therapeutic value in pediatric obstructive sleep-disordered breathing (oSDB). However, plant-based melatonin extraction faces limitations including long growth cycles, low yield, and complex purification procedures. Cyanobacteria, as photosynthetic microorganisms, offer distinct advantages such as rapid growth, low cultivation cost, and well-established genetic manipulation tools, making them ideal chassis cells for producing high-value natural products. Meanwhile, the molecular mechanisms linking tonsillar pathology to oSDB severity remain poorly understood, and translational therapeutic targets are urgently needed. METHODS: A novel cyanobacterial serotonin N-acetyltransferase gene (CySNAT3) was cloned, expressed in E. coli, and purified by Ni-NTA affinity chromatography. Its enzymatic activity was assessed by HPLC-fluorescence. Separately, differential expression analysis, WGCNA, and drug repurposing were performed on tonsillar RNA-seq data (GSE274855), followed by molecular docking to validate drug-target interactions. RESULTS: CySNAT3 catalyzed the conversion of serotonin to N-acetylserotonin and 5-MT to melatonin, providing an enzymatic tool for microbial melatonin production. Four high-confidence candidate drugs (sulfamethoxazole, cimetidine, diethylstilbestrol, clofibrate) were identified, with molecular docking confirming favorable binding affinities to their target proteins (CYP2C19, SLC47A1, WNT7A, SCD). CONCLUSION: Cimetidine and diethylstilbestrol have been experimentally linked to the melatonin pathway, suggesting that these four drugs may act through modulation of melatonin signaling. This study provides a new molecular foundation for pediatric oSDB treatment by integrating a novel cyanobacterial SNAT enzyme tool with transcriptome-derived drug candidates. CI - Copyright (c) 2026 Wen, Xu, Xu, Gao, Song, Lv and Yan. FAU - Wen, Wen AU - Wen W AD - School of Clinical Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China. FAU - Xu, Fei AU - Xu F AD - Department of Neonatology, Shangrao Municipal Hospital, Shangrao, China. FAU - Xu, Yaoming AU - Xu Y AD - Department of Pediatrics, Shangrao Municipal Hospital, Shangrao, China. FAU - Gao, Yifei AU - Gao Y AD - College of Chemistry and Materials Engineering, Quzhou University, Quzhou, China. FAU - Song, Honglin AU - Song H AD - Department of Pediatrics, Rongchang District People's Hospital, Chongqing, China. FAU - Lv, Yang AU - Lv Y AD - Department of Pediatrics, Rongchang District People's Hospital, Chongqing, China. FAU - Yan, Peng AU - Yan P AD - Cardiovascular Department, The First Affiliated Hospital of Chengdu Medical College, Chengdu, China. LA - eng PT - Journal Article DEP - 20260908 PL - Switzerland TA - Front Pharmacol JT - Frontiers in pharmacology JID - 101548923 PMC - PMC13593818 OTO - NOTNLM OT - cyanobacteria OT - drug repurposing OT - melatonin OT - obstructive sleep-disordered breathing OT - serotonin N-acetyltransferase COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/23 11:50 MHDA- 2026/09/23 11:51 PMCR- 2026/09/08 CRDT- 2026/09/23 06:05 PHST- 2026/04/09 00:00 [received] PHST- 2026/08/10 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/23 11:51 [medline] PHST- 2026/09/23 11:50 [pubmed] PHST- 2026/09/23 06:05 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - 1851793 [pii] AID - 10.3389/fphar.2026.1851793 [doi] PST - epublish SO - Front Pharmacol. 2026 Sep 8;17:1851793. doi: 10.3389/fphar.2026.1851793. eCollection 2026. PMID- 42774207 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260923 LR - 20260924 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Adaptation and usability study of the fear of cancer recurrence therapy for parents of survivors of childhood cancer (Parent-FORT). PG - 1815418 LID - 10.3389/fpsyg.2026.1815418 [doi] LID - 1815418 AB - INTRODUCTION: Fear of cancer recurrence (FCR) is a common and distressing concern for caregivers of survivors of cancer. At clinical levels, FCR is persistent, impairs quality of life, increases psychological distress, and increases health-system costs. Emerging evidence suggests that about half of parents of survivors of childhood cancer report clinically significant FCR, with associated negative impacts. No interventions currently target parent FCR. The Fear of Recurrence Therapy (FORT) group intervention efficaciously reduces FCR and improves quality of life for survivors of adult cancer. Our aim was to adapt FORT for virtual delivery for parents of survivors of childhood cancer and evaluate its usability. METHODS: Using the ADAPT and FRAME frameworks, we collaborated with 10 parents with lived experience to modify FORT for this population. Following adaptation, two trained therapists facilitated a usability trial of the adapted program (Parent-FORT) with one group of parents. Therapists and participants completed feedback questionnaires after each session to assess usefulness, usability, and readiness for future users, as well as a final exit interview. Descriptive statistics were used to summarize questionnaire data. Content analysis was used to summarize qualitative data from exit interviews. RESULTS: Five mothers whose children were diagnosed with childhood cancer were enrolled and four (Alberta, n = 2; Ontario, n = 2) completed the usability trial. Significant changes were made to the intervention language and content, resulting in an additional session. Key changes included the addition of exercises on navigating parent-child conversations about new physical symptoms and on exploring identity after cancer. Inclusion criteria were also broadened from one-year post-treatment to one-month post-treatment. Feedback indicated preliminary evidence of usability and acceptability. Qualitative analyses of exit interview data identified four themes: connectedness of the group, general format, satisfaction with the content and exercises, and overall impact. DISCUSSION: Parent-FORT reflects the first FCR intervention designed specifically for parents of survivors of childhood cancer. Meaningful co-design with parents was essential to the success of the adaptation. These preliminary findings support Parent-FORT's readiness for testing in a future feasibility pilot study. CI - Copyright (c) 2026 Holy, Brinson, Gibson-Haerle, Russell, Abbott, Giguere, Givogue, Guilcher, Heathcote, Johnson, McMillan, Maheu, Pelletier, Schulte, Sirois-Leclerc, Tutelman and Lebel. FAU - Holy, Celeste AU - Holy C AD - School of Psychology, University of Ottawa, Ottawa, ON, Canada. FAU - Brinson, Jeffery AU - Brinson J AD - Parent Partner, Hamilton, ON, Canada. FAU - Gibson-Haerle, Janelle AU - Gibson-Haerle J AD - Parent Partner, Hamilton, ON, Canada. FAU - Russell, K Brooke AU - Russell KB AD - School of Psychology, University of Ottawa, Ottawa, ON, Canada. FAU - Abbott, Lesleigh S AU - Abbott LS AD - Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. FAU - Giguere, Lauriane AU - Giguere L AD - School of Psychology, University of Ottawa, Ottawa, ON, Canada. FAU - Givogue, Amy AU - Givogue A AD - Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. FAU - Guilcher, Gregory M T AU - Guilcher GMT AD - Section of Pediatric Oncology/Cellular Therapy, Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. FAU - Heathcote, Lauren C AU - Heathcote LC AD - Health Psychology Section, Institute of Psychiatry, Psychology, & Neuroscience, King's College London, London, United Kingdom. FAU - Johnson, Emily AU - Johnson E AD - Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. FAU - McMillan, Kimberly AU - McMillan K AD - School of Nursing, Faculty of Health Sciences, University of Ottawa, Ottawa, ON, Canada. FAU - Maheu, Christine AU - Maheu C AD - Ingram School of Nursing, Faculty of Medicine and Health Sciences, McGill University & Research Institute, Montreal, QC, Canada. FAU - Pelletier, Wendy AU - Pelletier W AD - Department of Oncology, Division of Psychosocial Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. FAU - Schulte, Fiona AU - Schulte F AD - Section of Pediatric Oncology/Cellular Therapy, Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. AD - Department of Oncology, Division of Psychosocial Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. FAU - Sirois-Leclerc, Heloise AU - Sirois-Leclerc H AD - Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. FAU - Tutelman, Perri R AU - Tutelman PR AD - Department of Oncology, Division of Psychosocial Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. FAU - Lebel, Sophie AU - Lebel S AD - School of Psychology, University of Ottawa, Ottawa, ON, Canada. LA - eng PT - Journal Article DEP - 20260908 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13593775 OTO - NOTNLM OT - cancer OT - childhood neoplasms OT - fear of cancer recurrence (FCR) OT - group psychotheraphy OT - intervention OT - parents OT - psychology OT - survivors COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author CM declared that they were an editorial board member of Frontiers at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/09/23 11:50 MHDA- 2026/09/23 11:51 PMCR- 2026/09/08 CRDT- 2026/09/23 05:52 PHST- 2026/02/22 00:00 [received] PHST- 2026/06/24 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/09/23 11:51 [medline] PHST- 2026/09/23 11:50 [pubmed] PHST- 2026/09/23 05:52 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1815418 [doi] PST - epublish SO - Front Psychol. 2026 Sep 8;17:1815418. doi: 10.3389/fpsyg.2026.1815418. eCollection 2026. PMID- 42774164 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260924 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Critical and interactive digital health literacy and health information adoption among college students: a cross-sectional serial mediation study from a health communication perspective. PG - 1837883 LID - 10.3389/fpubh.2026.1837883 [doi] LID - 1837883 AB - BACKGROUND: Digital media have transformed how college students access, evaluate, and use health information. Although digital health literacy has been linked with risk perception, preventive behavior, self-care, and information seeking, less is known about its association with health information adoption as a downstream stage of digital health communication and the statistical pathways that may account for this association. OBJECTIVE: This study examined the cross-sectional association between critical and interactive digital health literacy and self-reported health information adoption among college students and estimated the specific indirect associations through health risk perception and exercise self-efficacy, separately and sequentially. METHODS: This cross-sectional study used a structured online questionnaire administered in three batches to college students from 12 institutions in Shandong Province, China, between September and November 2025. An independent pilot sample (n = 331) informed item-level assessment and scale reduction, and 3,148 formal-survey responses were included in the primary analysis. The primary scores were a 10-item health information adoption score, a 9-item critical and interactive digital health literacy score, an 8-item health risk perception score, and a 10-item exercise self-efficacy score. Analyses included descriptive statistics, group comparisons, Pearson correlations, reliability and measurement-model assessment, and ordinary least-squares path models corresponding to PROCESS Model 6. The adjusted model controlled for gender, academic year, major category, residential background, family economic status, and weekly internet-use frequency. Percentile bootstrap confidence intervals were calculated from 5,000 resamples. Analyses were conducted using SPSS 26.0 and Python; additional models assessed survey-batch and alternative-scoring sensitivity. RESULTS: Among the 3,148 participants, the mean scores were 30.83 (SD 8.24) for health information adoption, 29.21 (SD 6.25) for critical and interactive digital health literacy, 26.43 (SD 5.86) for health risk perception, and 32.35 (SD 8.17) for exercise self-efficacy. Digital health literacy was positively correlated with health information adoption (r = 0.416; P < 0.001). In the covariate-adjusted model, the total association between digital health literacy and health information adoption was B = 0.534. The direct association was B = 0.344 (64.3%). The specific indirect associations through health risk perception (effect = 0.090, bootstrap 95% CI 0.058-0.122; 16.9%), exercise self-efficacy (effect = 0.080, bootstrap 95% CI 0.059-0.101; 14.9%), and the serial health-risk-perception-to-exercise-self-efficacy pathway (effect = 0.020, bootstrap 95% CI 0.012-0.029; 3.8%) were statistically detectable. The total indirect association was 0.191 (bootstrap 95% CI 0.150-0.230; 35.7%). Results were materially similar after adjustment for survey batch and under alternative scoring specifications. CONCLUSIONS: Critical and interactive digital health literacy was positively associated with self-reported health information adoption among college students. Health risk perception and exercise self-efficacy provided separate and serial statistical indirect routes, but the direct association was the largest component and the serial route was comparatively small. Because the data were cross-sectional and self-reported, these estimates should be interpreted as statistical decompositions of associations rather than evidence of temporal or causal mediation. CI - Copyright (c) 2026 Sun, Zhao, Zhao and Ma. FAU - Sun, Yi AU - Sun Y AD - College of Basic Medicine, Jining Medical University, Jining, China. FAU - Zhao, Yang AU - Zhao Y AD - College of Foreign Languages, Weifang University, Weifang, Shandong, China. FAU - Zhao, Mingyu AU - Zhao M AD - School of Politics and Public Administration, Qufu Normal University, Rizhao, Shandong, China. FAU - Ma, Qian AU - Ma Q AD - College of Pharmacy, Jining Medical University, Rizhao, China. LA - eng PT - Journal Article DEP - 20260908 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Male MH - *Students/statistics & numerical data/psychology MH - Universities MH - *Health Literacy/statistics & numerical data MH - Digital Media MH - Young Adult MH - China MH - Surveys and Questionnaires MH - Digital Health MH - Self Efficacy MH - *Health Communication MH - Adult MH - Adolescent PMC - PMC13593750 OTO - NOTNLM OT - college students OT - cross-sectional study OT - digital health literacy OT - exercise self-efficacy OT - health information adoption OT - health risk perception COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/23 11:50 MHDA- 2026/09/23 11:51 PMCR- 2026/09/08 CRDT- 2026/09/23 05:45 PHST- 2026/03/24 00:00 [received] PHST- 2026/08/18 00:00 [revised] PHST- 2026/08/20 00:00 [accepted] PHST- 2026/09/23 11:51 [medline] PHST- 2026/09/23 11:50 [pubmed] PHST- 2026/09/23 05:45 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1837883 [doi] PST - epublish SO - Front Public Health. 2026 Sep 8;14:1837883. doi: 10.3389/fpubh.2026.1837883. eCollection 2026. PMID- 42773386 OWN - NLM STAT- MEDLINE DCOM- 20260922 LR - 20260925 IS - 1554-3528 (Electronic) IS - 1554-351X (Print) IS - 1554-351X (Linking) VI - 58 IP - 11 DP - 2026 Sep 22 TI - Creating and validating photorealistic AI-generated facial expression stimuli for emotion research. LID - 10.3758/s13428-026-03156-0 [doi] LID - 296 AB - The development of AI-generated facial expression stimuli offers researchers unprecedented control over stimulus characteristics while maintaining photorealistic quality. However, rigorous validation methodologies are essential to ensure these stimuli function effectively in behavioral research. This paper presents a comprehensive three-study validation framework for AI-generated facial expression stimuli that systematically varied body weight and emotional expressions. Study 1 validated 72 stimuli across three emotions (happiness, sadness, neutrality) and three weight categories using both computational and human validation approaches. Study 2 extended this framework to include anger as a fourth emotion while controlling for individual facial features through same-character methodology. Study 2b further assessed valence, intensity, naturalness, authenticity, and non-focal emotion ratings of the same stimuli from Study 2. Across studies, the stimuli demonstrated successful emotion and weight manipulations, with AI-generated images achieving photorealistic quality that participants could not reliably distinguish from real photographs. Computational validation showed high intended-emotion likelihood in Py-Feat, while human validation confirmed appropriate perception of the target emotions, body weight, realism, age, and broader expression-quality dimensions. This dual validation approach-combining automated computational assessment with human behavioral validation-provides a robust framework for ensuring AI-generated stimuli meet research standards. The methodology offers significant advantages for behavioral research, enabling precise control over stimulus characteristics while maintaining ecological validity and addressing ethical considerations in stimulus development. CI - (c) 2026. The Author(s). FAU - Hareli, Shlomo AU - Hareli S AD - The Laboratory for the Study of Social Perception of Emotions, School of Business Administration, The Herta & Paul Amir Faculty of Social Sciences, University of Haifa, 199 Aba Khoushy Ave., Mount Carmel, Israel. shareli@univ.haifa.ac.il. FAU - David, Shlomo AU - David S AD - The Laboratory for the Study of Social Perception of Emotions, School of Business Administration, The Herta & Paul Amir Faculty of Social Sciences, University of Haifa, 199 Aba Khoushy Ave., Mount Carmel, Israel. LA - eng PT - Journal Article PT - Validation Study DEP - 20260922 PL - United States TA - Behav Res Methods JT - Behavior research methods JID - 101244316 SB - IM MH - Humans MH - *Facial Expression MH - *Emotions/physiology MH - Female MH - Male MH - Adult MH - Young Adult MH - Generative Artificial Intelligence MH - *Photic Stimulation/methods MH - Adolescent MH - Reproducibility of Results MH - Body Weight PMC - PMC13597571 OTO - NOTNLM OT - Artificial intelligence OT - Body weight OT - Emotion perception OT - Facial expressions OT - Stimulus validation COIS- Declarations. Ethics approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments. The study was approved by the Ethics Committee of The Herta & Paul Amir Faculty of Social Sciences, University of Haifa (No. 381/24). Consent to participate: Informed consent was obtained from all participants prior to their participation. Consent for publication: All participants provided consent for their anonymized data to be used for research purposes. Conflicts of interest/Competing interests: The authors have no competing interests to declare. Open practices statement: All validation data, participant responses, generated stimulus datasets, and supplementary materials are openly available via OSF at: https://osf.io/mbg4j/?view_only=a0c0512fa2b04cc19c335cc2bd299017 . This includes complete raw datasets for all studies, data codebooks, all AI-generated stimuli, PyFeat and FaceShape analysis results, complete analysis reports, and supplementary materials. All computational code and workflows are openly available in the same OSF repository, including R Markdown files, Python scripts, ComfyUI workflow specifications (.json files), LoRA models (.safetensors files), and step-by-step instructions. AI assistance disclosure: During the preparation of this work, the authors used Claude AI to assist with developing the Py-Feat validation script and improving language. To ensure scientific accuracy, all AI-generated outputs were thoroughly reviewed by the authors. The authors take full responsibility for the content of the publication. EDAT- 2026/09/23 05:35 MHDA- 2026/09/23 05:36 PMCR- 2026/09/22 CRDT- 2026/09/22 23:34 PHST- 2025/08/05 00:00 [received] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/09/23 05:36 [medline] PHST- 2026/09/23 05:35 [pubmed] PHST- 2026/09/22 23:34 [entrez] PHST- 2026/09/22 00:00 [pmc-release] AID - 10.3758/s13428-026-03156-0 [pii] AID - 3156 [pii] AID - 10.3758/s13428-026-03156-0 [doi] PST - epublish SO - Behav Res Methods. 2026 Sep 22;58(11):296. doi: 10.3758/s13428-026-03156-0. PMID- 42773043 OWN - NLM STAT- Publisher LR - 20260922 IS - 1578-1879 (Electronic) IS - 0214-9168 (Linking) DP - 2026 Sep 22 TI - Early-life atherogenesis: Mechanistic pathways, risk architecture, and clinical implications in pediatric populations. PG - 500964 LID - S0214-9168(26)00073-2 [pii] LID - 10.1016/j.arteri.2026.500964 [doi] AB - Atherosclerosis is now recognized as a long-term biological process whose origins may be established early in life, well before the clinical expression of cardiovascular disease. The increasing prevalence of pediatric obesity, insulin resistance, sedentary behavior, and unhealthy dietary patterns has intensified interest in understanding how vascular risk is shaped from childhood onward. This narrative review examines early-life atherogenesis in pediatric populations from mechanistic, clinical, and preventive perspectives, with emphasis on cardiometabolic risk factors, endothelial dysfunction, vascular inflammation, and potential biomarkers of subclinical vascular injury. A narrative synthesis of current evidence was conducted to integrate mechanistic, clinical, and preventive aspects of pediatric atherogenesis, focusing on biological pathways, developmental determinants, lifestyle-related exposures, and emerging tools for early risk stratification. Sustained exposure to adverse cardiometabolic factors during childhood and adolescence may promote subclinical vascular alterations and establish risk trajectories that persist into adulthood. This process involves the interaction of atherogenic dyslipidemia, oxidative stress, chronic low-grade inflammation, immune activation, endothelial dysfunction, and vascular remodeling. Circulating biomarkers of endothelial activation and vascular inflammation may serve as early indicators of subclinical injury and provide complementary information for identifying children with increased cardiometabolic vulnerability. Genetic susceptibility, pubertal development, sex-related differences, socioeconomic conditions, and lifestyle-related factors further modulate the expression and severity of risk. Early identification of children with unfavorable cardiometabolic profiles requires the integration of conventional clinical assessment with biomarkers, derived lipid parameters, and complementary stratification tools that still require further pediatric validation. Understanding pediatric atherogenesis as an integrated process shaped by biology, development, and environment may help guide more timely strategies for prevention, follow-up, and intervention aimed at reducing future cardiovascular burden. CI - Copyright (c) 2026 Sociedad Espanola de Arteriosclerosis. Publicado por Elsevier Espana, S.L.U. All rights reserved. FAU - de la Torre-Sosa, Citlaly Natali AU - de la Torre-Sosa CN AD - Departamento de Salud, El Colegio de la Frontera Sur (ECOSUR), Unidad Villahermosa, Carretera a Reforma Km. 15.5 s/n, Rancheria Guineo 2da Seccion, CP 86280, Villahermosa, Tabasco, Mexico. FAU - Lopez-Marure, Rebeca AU - Lopez-Marure R AD - Departamento de Fisiologia (Biologia Celular), Instituto Nacional de Cardiologia "Ignacio Chavez", Tlalpan, CP 14080, Ciudad de Mexico, Mexico. FAU - Ochoa-Diaz-Lopez, Hector AU - Ochoa-Diaz-Lopez H AD - Departamento de Salud, El Colegio de la Frontera Sur (ECOSUR), Unidad San Cristobal, San Cristobal de las Casas, Chiapas, Mexico. FAU - Irecta-Najera, Cesar Antonio AU - Irecta-Najera CA AD - Departamento de Salud, El Colegio de la Frontera Sur (ECOSUR), Unidad Villahermosa, Carretera a Reforma Km. 15.5 s/n, Rancheria Guineo 2da Seccion, CP 86280, Villahermosa, Tabasco, Mexico. Electronic address: cirecta@ecosur.mx. LA - eng LA - spa PT - Journal Article PT - Review DEP - 20260922 PL - Spain TA - Clin Investig Arterioscler JT - Clinica e investigacion en arteriosclerosis : publicacion oficial de la Sociedad Espanola de Arteriosclerosis JID - 9208512 SB - IM OTO - NOTNLM OT - Aterogenesis OT - Atherogenesis OT - Cardiovascular risk factors OT - Epidemiology OT - Epidemiologia OT - Factores de riesgo cardiovascular OT - Pediatric population OT - Poblacion pediatrica EDAT- 2026/09/22 23:33 MHDA- 2026/09/22 23:33 CRDT- 2026/09/22 21:57 PHST- 2026/06/11 00:00 [received] PHST- 2026/08/05 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/09/22 23:33 [medline] PHST- 2026/09/22 23:33 [pubmed] PHST- 2026/09/22 21:57 [entrez] AID - S0214-9168(26)00073-2 [pii] AID - 10.1016/j.arteri.2026.500964 [doi] PST - aheadofprint SO - Clin Investig Arterioscler. 2026 Sep 22:500964. doi: 10.1016/j.arteri.2026.500964. PMID- 42772898 OWN - NLM STAT- Publisher LR - 20260922 IS - 1468-3296 (Electronic) IS - 0040-6376 (Linking) DP - 2026 Sep 22 TI - Systematic misclassification of lung function in Indian adolescents using GLI-2012 reference equations: evidence from the multicity APEAL cohort. LID - thorax-2026-225309 [pii] LID - 10.1136/thorax-2026-225309 [doi] AB - BACKGROUND: Accurate spirometric interpretation depends on appropriate reference equations. The Global Lung Function Initiative (GLI-2012) equations are widely used internationally, but South Asian populations were sparsely represented in their derivation and their applicability in Indian adolescents remains uncertain. METHODS: We performed a cross-sectional analysis of baseline data from the multicity Air Pollution Exposure on Adolescents' Lungs cohort. Healthy, non-smoking school-going adolescents aged 11-14 years from Delhi, Mumbai, Bengaluru and Mysuru underwent spirometry using standardised American Thoracic Society/European Respiratory Society procedures. GLI-2012 z-scores for forced expiratory volume in 1 s (FEV(1)), forced vital capacity (FVC) and FEV(1)/FVC were calculated using the Asian reference category. Fit was assessed using mean z-scores and the proportion below the lower limit of normal (LLN; z<-1.645). RESULTS: Among 4175 adolescents (2148 males), mean z-scores were -2.44 (SD 1.27) for FEV(1), -1.34 (0.93) for FVC and -0.78 (1.11) for FEV(1)/FVC, all well outside the accepted +/-0.5 range for adequate fit. Overall, 74.6% were below the LLN for FEV(1), 36.8% for FVC and 19.3% for FEV(1)/FVC, compared with the expected 5% in a well-calibrated healthy population. The leftward shift in z-score distributions was consistent across sex, city, age, height and body mass index strata. CONCLUSION: GLI-2012 equations, as currently applied in the absence of South Asian-specific references, demonstrated substantial calibration mismatch relative to this cohort of Indian adolescents and risk major overclassification of low lung function. Population-specific validation and recalibration are needed before routine clinical or epidemiological use in this population. CI - (c) Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Samdarshi, Priya AU - Samdarshi P AUID- ORCID: 0009-0007-6396-0876 AD - Environmental Science and Engineering Department, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India. FAU - Mahesh, Padukudru Anand AU - Mahesh PA AUID- ORCID: 0000-0003-1632-5945 AD - Respiratory Medicine, JSS Medical College and Hospital, Mysore, Karnataka, India. FAU - Patil, Swapnali AU - Patil S AD - Environmental Science and Engineering Department, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India. FAU - Mohan, Anant AU - Mohan A AD - Pulmonary, Critical Care and Sleep Medicine, All India Institute of Medical Sciences New Delhi, New Delhi, Delhi, India. FAU - D'Souza, George AU - D'Souza G AD - Department of Pulmonary Medicine, St John's Medical College, Bengaluru, Karnataka, India. FAU - Thimmulappa, Rajesh AU - Thimmulappa R AD - Department of Biochemistry, JSS Medical College, Mysuru, Karnataka, India. FAU - Agrawal, Twinkle AU - Agrawal T AD - Department of Community Health, St John's National Academy of Health Sciences, Bengaluru, Karnataka, India. FAU - Biligere Siddaiah, Jayaraj AU - Biligere Siddaiah J AD - Department of Respiratory Medicine, JSS Medical College, Mysuru, Karnataka, India. FAU - Phuleria, Harish Chandra AU - Phuleria HC AD - Environmental Science and Engineering Department, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India phuleria@iitb.ac.in. AD - Centre for Climate Studies, Indian Institute of Technology Bombay, Mumbai, Maharashtra, India. LA - eng PT - Journal Article DEP - 20260922 PL - England TA - Thorax JT - Thorax JID - 0417353 SB - IM OTO - NOTNLM OT - Forced Expiratory Volume OT - Respiratory Function Tests OT - Respiratory Infection OT - Respiratory Measurement COIS- Competing interests: None declared. EDAT- 2026/09/22 23:33 MHDA- 2026/09/22 23:33 CRDT- 2026/09/22 21:23 PHST- 2026/04/25 00:00 [received] PHST- 2026/09/03 00:00 [accepted] PHST- 2026/09/22 23:33 [medline] PHST- 2026/09/22 23:33 [pubmed] PHST- 2026/09/22 21:23 [entrez] AID - thorax-2026-225309 [pii] AID - 10.1136/thorax-2026-225309 [doi] PST - aheadofprint SO - Thorax. 2026 Sep 22:thorax-2026-225309. doi: 10.1136/thorax-2026-225309. PMID- 42772725 OWN - NLM STAT- Publisher LR - 20260922 IS - 1543-2920 (Electronic) IS - 0899-8493 (Linking) DP - 2026 Sep 22 TI - Test-Retest Reliability of In Vivo Structure and Mechanical Properties of the Achilles Tendon in Youth With Obesity. PG - 1-9 LID - 10.1123/pes.2025-0127 [doi] AB - PURPOSE: To assess the test-retest reliability of in vivo Achilles tendon (AT) structure and mechanical properties in youth with obesity. METHODS: Participants (11 males; 12 females; age: 12.00 [2.07] y; body mass index z score: 2.93 [0.59]) were assessed for AT (1) length, (2) cross-sectional area, (3) moment arm, (4) force, (5) deformation, (6) stress, (7) strain, (8) stiffness, (9) Young's modulus, (10) plantar flexor maximal isometric voluntary contraction, and (11) tibialis anterior co-activation. Reliability was assessed using the intraclass correlation coefficient, coefficient of variation, Bland-Altman, standard error of the measurement, and minimum detectable change. The intraclass correlation coefficient values were classified as excellent (>/=.90), good (>/=.75 to <.90), moderate (>.49 to <.75), and poor ( control beliefs [95% CI (0.1135, 0.2500)]. Perceived susceptibility and barriers were indirectly related to lower control beliefs, and this relationship did not operate through attitude. Subjective norm was associated with intention, fully mediated by control beliefs (Effect = 0.3505). Control beliefs showed the largest predictive effect size on intention in the present model (beta = 0.824, p < 0.001). CONCLUSION: Continuous post-injury exercise intention was associated with a stepwise path of attitude --> control beliefs --> intention. Perceived health benefits were associated with intention through this chain, while the pattern for perceived severity was consistent with fear-avoidance theory. Control beliefs connected internal values and social norms. The findings suggest that interventions may benefit from shifting from risk intimidation to benefit empowerment, and from reconstructing rehabilitation control through social support networks-though these candidate directions await experimental validation. CI - Copyright (c) 2026 Hu and Chen. FAU - Hu, Xuanming AU - Hu X AD - School of Sports Science and Physical Education, Nanjing Normal University, Nanjing, Jiangsu, China. FAU - Chen, Peiyou AU - Chen P AD - School of Sports Science and Physical Education, Nanjing Normal University, Nanjing, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260907 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Intention MH - Theory of Planned Behavior MH - *Athletic Injuries/rehabilitation/psychology MH - Female MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - Universities MH - *Exercise/psychology MH - *Health Belief Model MH - Self Efficacy MH - *Students/psychology/statistics & numerical data MH - Surveys and Questionnaires MH - Adult MH - Adolescent PMC - PMC13590716 OTO - NOTNLM OT - Health Belief Model OT - Theory of Planned Behavior OT - chained mediation model OT - control beliefs regarding exercise rehabilitation OT - university students COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/22 12:42 MHDA- 2026/09/22 12:43 PMCR- 2026/09/07 CRDT- 2026/09/22 05:43 PHST- 2026/05/29 00:00 [received] PHST- 2026/08/12 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/22 12:43 [medline] PHST- 2026/09/22 12:42 [pubmed] PHST- 2026/09/22 05:43 [entrez] PHST- 2026/09/07 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1894556 [doi] PST - epublish SO - Front Public Health. 2026 Sep 7;14:1894556. doi: 10.3389/fpubh.2026.1894556. eCollection 2026. PMID- 42768931 OWN - NLM STAT- Publisher LR - 20260922 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) DP - 2026 Sep 22 TI - Disability in pediatric inflammatory bowel diseases: A systematic review and a single center experience. LID - 10.1002/jpn3.70596 [doi] AB - OBJECTIVES: Toward development of a pediatric IBD disability index (PIDI), we aimed to review the literature on disability in pediatric inflammatory bowel disease (PIBD) and to estimate disability rates in a pediatric inception cohort. METHODS: A systematic review identified studies reporting disability in PIBD and in adult randomized controlled trials (RCTs) with disability as the primary outcome. In parallel, seven disability-related IMPACT-III items were retrieved at 4 and 12 months after diagnosis from a prospectively followed inception cohort of PIBD. Items were scored 0-100 (/=15 years of age and residents of Saskatchewan. Participants will complete four home visits over the study period. Baseline home visits will occur when infants are approximately 2 months of age, during which frozen PDHM will be delivered to homes. PDHM will be used as a supplement to infant formula or breastfeeding. Caregivers will record PDHM usage and infant tolerance using structured tracking forms. Follow-up visits will occur every 2-3 weeks for PDHM delivery and bottle counts, with weekly check-ins for support. Clinical pilot data will include infant anthropometrics and serious illness events collected during study visits and abstracted from medical records. Descriptive analyses will summarise PDHM intake, tolerance and caregiver experiences. ETHICS AND DISSEMINATION: Ethical approval was obtained from the University of Saskatchewan Biomedical Research Ethics Board (BIO 5307) and the Saskatchewan Health Authority. Findings will be disseminated through peer-reviewed publications and conference presentations. TRIAL REGISTRATION NUMBER: NCT06955715. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Langen, Chloe AU - Langen C AUID- ORCID: 0009-0001-7659-2298 AD - College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada. FAU - Blackburn, David AU - Blackburn D AUID- ORCID: 0000-0002-7831-5913 AD - College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada. FAU - Purewal, Rupeena AU - Purewal R AD - College of Medicine, University of Saskatchewan, Saskatoon, Canada. FAU - Cochrane, Kelsey M AU - Cochrane KM AD - College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, Canada Kelsey.Cochrane@usask.ca. LA - eng SI - ClinicalTrials.gov/NCT06955715 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260921 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Adult MH - Female MH - Humans MH - Infant MH - Infant, Newborn MH - Male MH - Breast Feeding MH - Caregivers MH - Feasibility Studies MH - *HIV Infections/transmission/prevention & control MH - *Infectious Disease Transmission, Vertical/prevention & control MH - *Milk, Human MH - *Pasteurization MH - Saskatchewan MH - Clinical Trials as Topic PMC - PMC13599818 OTO - NOTNLM OT - Caregivers OT - HIV & AIDS OT - Health Equity OT - Paediatric infectious disease & immunisation OT - Public health COIS- Competing interests: None declared. EDAT- 2026/09/21 23:33 MHDA- 2026/09/21 23:34 PMCR- 2026/09/21 CRDT- 2026/09/21 20:54 PHST- 2026/09/21 23:34 [medline] PHST- 2026/09/21 23:33 [pubmed] PHST- 2026/09/21 20:54 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - bmjopen-2026-120638 [pii] AID - 10.1136/bmjopen-2026-120638 [doi] PST - epublish SO - BMJ Open. 2026 Sep 21;16(9):e120638. doi: 10.1136/bmjopen-2026-120638. PMID- 42767740 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20260925 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 9 DP - 2026 Sep 21 TI - Diagnostic accuracy of growth hormone stimulation tests for growth hormone deficiency following radiotherapy involving the hypothalamic-pituitary axis: protocol for a systematic review and planned meta-analysis. PG - e125247 LID - 10.1136/bmjopen-2026-125247 [doi] LID - e125247 AB - INTRODUCTION: Radiotherapy is part of the treatment for many intracranial tumours, head and neck cancers and haematological malignancies. In these cases, the hypothalamic-pituitary (HP) axis is often included within the radiation field and can be damaged as an organ at risk. As survival improves, an increasing number of patients are living with late endocrine complications, particularly growth hormone deficiency (GHD). Diagnosing GHD in this context is challenging, as much of the evidence supporting growth hormone (GH) stimulation tests comes from populations with fundamentally different disease mechanisms. We aim to conduct a systematic review, and meta-analysis where feasible, to assess the diagnostic accuracy of GH stimulation tests for diagnosing GHD in children, teenagers, young adults and adults who have received radiotherapy involving the HP axis. METHODS AND ANALYSIS: Eligible studies will include patients exposed to radiotherapy involving the HP axis, who subsequently underwent GH stimulation testing for suspected GHD. Index tests will include commonly used stimulation tests such as the insulin tolerance test, glucagon stimulation test, arginine stimulation test, clonidine stimulation test, GH-releasing hormone-arginine stimulation test and macimorelin stimulation test. Reference standards will include clinical criteria (>/=2 additional pituitary hormone deficiencies) or alternative GH stimulation tests. Searches will be conducted in MEDLINE, Embase, Cochrane Library and PubMed. Two independent reviewers will screen studies, collect data, evaluate risk of bias using Quality Assessment of Diagnostic Accuracy Studies-2 and assess reporting quality using the Standards for Reporting of Diagnostic Accuracy Studies criteria. Sensitivity and specificity will be extracted. Where studies are sufficiently comparable, results will be pooled using hierarchical bivariate and summary receiver operating characteristic models. Prespecified subgroup analyses will explore heterogeneity by age group, body mass index, ethnicity, radiotherapy dose and time since treatment. ETHICS AND DISSEMINATION: Ethical approval is not required as this systematic review summarises published data only. We will share our findings through peer-reviewed publications, conference presentations and engagement with relevant clinical teams to improve diagnostic decision-making in our population of interest. PROSPERO REGISTRATION NUMBER: CRD420261415689. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Chen, Lillian Ruiheng AU - Chen LR AUID- ORCID: 0009-0008-7983-1865 AD - Department of Endocrinology, The Christie NHS Foundation Trust, Manchester, UK lillian.chen@nhs.net. FAU - Perry, Melissa Betty AU - Perry MB AD - Christie Patient Centred Research, The Christie NHS Foundation Trust, Manchester, UK. FAU - Salomon Estebanez, Maria AU - Salomon Estebanez M AD - Department of Paediatric Endocrinology, Royal Manchester Children's Hospital, Manchester, UK. FAU - Livesey, Daniel AU - Livesey D AD - The Christie Institute for Cancer Education, The Christie NHS Foundation Trust, Manchester, UK. FAU - Martin, Glen Philip AU - Martin GP AUID- ORCID: 0000-0002-3410-9472 AD - Division of Informatics, Imaging and Data Science, The University of Manchester, Manchester, UK. FAU - Higham, Claire E AU - Higham CE AD - Department of Endocrinology, The Christie Hospital NHS Trust, Manchester, UK. AD - Division of Cancer Sciences, The University of Manchester, Manchester, UK. AD - Manchester Biomedical Research Centre (BRC), NIHR, Manchester, UK. LA - eng PT - Journal Article DEP - 20260921 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - 12629-01-5 (Human Growth Hormone) SB - IM MH - Humans MH - Systematic Reviews as Topic MH - *Hypothalamo-Hypophyseal System/radiation effects MH - Meta-Analysis as Topic MH - *Human Growth Hormone/deficiency MH - *Radiotherapy/adverse effects MH - Research Design PMC - PMC13599972 OTO - NOTNLM OT - Cancer Survivors OT - Diabetes & endocrinology OT - Pituitary disorders OT - RADIOTHERAPY OT - Sensitivity and Specificity OT - Systematic Review COIS- Competing interests: None declared. EDAT- 2026/09/21 23:33 MHDA- 2026/09/21 23:34 PMCR- 2026/09/21 CRDT- 2026/09/21 20:54 PHST- 2026/09/21 23:34 [medline] PHST- 2026/09/21 23:33 [pubmed] PHST- 2026/09/21 20:54 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - bmjopen-2026-125247 [pii] AID - 10.1136/bmjopen-2026-125247 [doi] PST - epublish SO - BMJ Open. 2026 Sep 21;16(9):e125247. doi: 10.1136/bmjopen-2026-125247. PMID- 42766906 OWN - NLM STAT- Publisher LR - 20260921 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 91 DP - 2026 Sep 21 TI - Facilitating participation and child-centered care: co-designing narrative and play-based communication tools for young children with type 1 diabetes. PG - 814-828 LID - S0882-5963(26)00455-0 [pii] LID - 10.1016/j.pedn.2026.09.006 [doi] AB - PURPOSE: Young children with type 1 diabetes are often marginalized in clinical consultations due to communication practices that favor verbal, adult-centered interaction. Developmentally attuned methods to support young children's meaningful participation in routine diabetes care remain limited. This study aimed to develop and examine Child-Centered Narrative Play Tools (CNPTs) and explore how they support participation, communication, expression of agency, and assess their feasibility in pediatric diabetes consultations. DESIGN AND METHODS: An iterative participatory qualitative design was conducted across two specialist pediatric diabetes clinics in Denmark. Twenty-nine children aged 3-7 years, 29 caregivers, and 12 healthcare professionals participated in workshops, exploratory testing, video-recorded clinical observations, and semi-structured interviews. Narrative story stems and play materials were co-developed and refined through cycles of testing and feedback. Data were analyzed using thematic analysis, combining inductive coding with theory-informed interpretation. RESULTS: Narrative play functioned as a primary medium through which young children expressed experiences, demonstrated understanding of diabetes management, and exercised agency during consultations. The tools enabled children to articulate everyday experiences of diabetes management and emotional responses that were often not expressed in standard consultations. Healthcare professionals reported increased confidence in communicating at the child's developmental level, and caregivers observed greater ownership and recall of consultation content. Feasibility testing indicated that the tools were feasible for routine clinical practice, with high acceptability and good usability following appropriate training. PRACTICE IMPLICATIONS: Child-Centered Narrative Play Tools (CNPTs) offer pediatric HCPs a feasible, theory-informed framework to operationalize child-centered care and make young children's perspectives visible and actionable in routine diabetes practice. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - DeCosta, Patricia AU - DeCosta P AD - Department of Prevention, Health Promotion & Community Care, Steno Diabetes Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. Electronic address: patricia.decosta@regionh.dk. FAU - Madsen, Mette AU - Madsen M AD - Department of Pediatrics and Adolescent Medicine, Aalborg University Hospital, Aalborg, Denmark; Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. FAU - Hasselbalch, Line Aagaard AU - Hasselbalch LA AD - Department of Pediatrics and Adolescent Medicine, Aalborg University Hospital, Aalborg, Denmark; Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark. FAU - Vedel, Lotte Dyrmann AU - Vedel LD AD - Department of Pediatrics and Adolescent Medicine, Aalborg University Hospital, Aalborg, Denmark; Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark. FAU - Knudsen, Jeanette AU - Knudsen J AD - Department of Diabetes Care, Children and Adolescent, Steno Diabetes Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Aistrup, Malene Ofjord AU - Aistrup MO AD - Department of Diabetes Care, Children and Adolescent, Steno Diabetes Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Matthews, Maja AU - Matthews M AD - Department of Diabetes Care, Children and Adolescent, Steno Diabetes Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Petersen, Ina Ehlers AU - Petersen IE AD - Department of Diabetes Care, Children and Adolescent, Steno Diabetes Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark. FAU - Pilgaard, Kasper Ascanius AU - Pilgaard KA AD - Department of Diabetes Care, Children and Adolescent, Steno Diabetes Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark; Department of Pediatrics, Herlev Hospital, Denmark. FAU - Hagstrom, Soren AU - Hagstrom S AD - Department of Pediatrics and Adolescent Medicine, Aalborg University Hospital, Aalborg, Denmark; Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark. FAU - Ejskjaer, Niels AU - Ejskjaer N AD - Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark; Department of Endocrinology, Aalborg University Hospital, Denmark. FAU - Grabowski, Dan AU - Grabowski D AD - Department of Prevention, Health Promotion & Community Care, Steno Diabetes Center Copenhagen, Copenhagen University Hospital, Copenhagen, Denmark; Department of Public Health, University of Southern Denmark, Odense, Denmark. LA - eng PT - Journal Article DEP - 20260921 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM OTO - NOTNLM OT - Diabetes mellitus, type 1 OT - Health communication OT - Patient participation OT - Pediatric nursing OT - Qualitative research COIS- Declaration of competing interest The authors declare that they have no known financial or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/21 23:33 MHDA- 2026/09/21 23:33 CRDT- 2026/09/21 18:01 PHST- 2026/02/23 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/03 00:00 [accepted] PHST- 2026/09/21 23:33 [medline] PHST- 2026/09/21 23:33 [pubmed] PHST- 2026/09/21 18:01 [entrez] AID - S0882-5963(26)00455-0 [pii] AID - 10.1016/j.pedn.2026.09.006 [doi] PST - aheadofprint SO - J Pediatr Nurs. 2026 Sep 21;91:814-828. doi: 10.1016/j.pedn.2026.09.006. PMID- 42766798 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260921 LR - 20260923 IS - 2369-2529 (Print) IS - 2369-2529 (Electronic) IS - 2369-2529 (Linking) VI - 13 DP - 2026 Sep 21 TI - Delivering Virtual Group Interventions for Youth With Persisting Symptoms After Concussion (Move&Connect-Youth) and Their Caregivers (Move&Connect-Caregivers): Fidelity and Engagement Evaluation. PG - e88771 LID - 10.2196/88771 [doi] LID - e88771 AB - BACKGROUND: Youth with persisting symptoms after concussion (PSaC) can experience ongoing physical, cognitive, and emotional challenges, and their caregivers experience increased stress. There are currently limited interventions that support youth with PSaC or their caregivers. Move&Connect is a virtual group program with 2 parallel interventions: Move&Connect-Youth (M&C-Y) and Move&Connect-Caregivers (M&C-C). M&C-Y includes concussion education, active rehabilitation, and goal setting. M&C-C uses psychoeducation and practical tools to promote family communication and problem solving. OBJECTIVE: Within the context of a broader pilot study of M&C-Y and M&C-C, we completed a fidelity and engagement evaluation with the objectives of (1) evaluating intervention fidelity and (2) exploring facilitators and barriers to youth and caregiver engagement. METHODS: M&C-Y and M&C-C were delivered virtually using Zoom Healthcare and ran in parallel. Youth with PSaC and caregivers were recruited from a children's rehabilitation hospital in Ontario, Canada. Intervention fidelity was evaluated according to the 5 principles of fidelity from Bellg et al: design, training, delivery, receipt, and enactment. Intervention delivery, attendance, and engagement ratings were monitored through weekly logs and field notes. Participants completed exit satisfaction surveys, and a subset of youth and caregivers completed semistructured interviews to understand facilitators and barriers to engagement. Descriptive statistics were used to analyze logs and surveys. Directed content analysis, guided by a motivational framework, and inductive coding to identify barriers and facilitators to engagement were applied to qualitative data. RESULTS: A total of 34 youth (age: mean 15.1, SD 2.28 years) and 36 caregivers (age: mean 48.9, SD 5.92 years) participated in 10 M&C-Y and 9 M&C-C groups, respectively. Most youth identified as girls (24/34, 71%), and most caregivers identified as mothers (30/36, 83%). Clinician facilitators adhered to the components of the intervention protocols between 92% and 97% of the time in M&C-Y and 82% and 93% of the time in M&C-C. The majority of youth (22/34, 65%) and caregivers (24/36, 67%) attended 5 or more sessions. In addition, 82% (28/34) of youth and 94% (34/36) of caregivers agreed they would recommend the interventions to others. Qualitative findings revealed youth engagement was supported by motivation, comfort in the virtual setting, interactive intervention components, feelings of trust, and diverse and modifiable exercises. Barriers to youth engagement included ongoing symptoms, discrepancies between exercises and physical abilities, and previous knowledge of education. Caregiver engagement was facilitated by perceived benefits of M&C-C, emotional connection and validation, and comfort and convenience of the virtual setting. Barriers to caregiver engagement included stress, competing scheduling demands, and limited reminders or access to intervention materials. CONCLUSIONS: The pilot study of M&C-Y and M&C-C was conducted with high delivery adherence. Exit satisfaction surveys combined with qualitative data revealed high levels of caregiver satisfaction and engagement, whereas youth satisfaction and engagement had some variability, particularly related to the exercise. Findings demonstrate important implications for delivering virtual group interventions for youth with PSaC and their caregivers. CI - (c) Andrea Hickling, Hiba Al-Hakeem, Andrew Lovell, Sophie Madge-Nyren, Kylie D Mallory, Jennifer L Ryan, Christine F Provvidenza, Ruth Wilcock, Patricia Knapp, Brenda Knapp, Shari L Wade, Keith Owen Yeates, Shannon E Scratch. Originally published in JMIR Rehabilitation and Assistive Technology (https://rehab.jmir.org). FAU - Hickling, Andrea AU - Hickling A AUID- ORCID: 0000-0001-6251-6369 AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. AD - Department of Occupational Science and Occupational Therapy, University of Toronto, Toronto, ON, Canada. FAU - Al-Hakeem, Hiba AU - Al-Hakeem H AUID- ORCID: 0000-0001-8290-5943 AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. AD - Department of Psychology, University of Windsor, Windsor, ON, Canada. FAU - Lovell, Andrew AU - Lovell A AUID- ORCID: 0000-0001-9985-0432 AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. FAU - Madge-Nyren, Sophie AU - Madge-Nyren S AUID- ORCID: 0009-0005-7508-3108 AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. FAU - Mallory, Kylie D AU - Mallory KD AUID- ORCID: 0009-0005-6608-378X AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. AD - Department of Occupational Science and Occupational Therapy, University of Toronto, Toronto, ON, Canada. FAU - Ryan, Jennifer L AU - Ryan JL AUID- ORCID: 0000-0001-7516-9562 AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. FAU - Provvidenza, Christine F AU - Provvidenza CF AUID- ORCID: 0000-0002-1741-239X AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. FAU - Wilcock, Ruth AU - Wilcock R AUID- ORCID: 0009-0008-7429-6576 AD - Ontario Brain Injury Association, Thorold, ON, Canada. FAU - Knapp, Patricia AU - Knapp P AUID- ORCID: 0009-0004-4697-422X AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. FAU - Knapp, Brenda AU - Knapp B AUID- ORCID: 0009-0002-5022-9041 AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. FAU - Wade, Shari L AU - Wade SL AUID- ORCID: 0000-0003-3764-7126 AD - Division of Rehabilitation Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States. AD - Department of Pediatrics, University of Cincinnati, Cincinnati, OH, United States. FAU - Yeates, Keith Owen AU - Yeates KO AUID- ORCID: 0000-0001-7680-2892 AD - Department of Psychology, Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada. FAU - Scratch, Shannon E AU - Scratch SE AUID- ORCID: 0000-0001-9191-2571 AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Rd, Toronto, ON, M4G1R8, Canada, 1 416-425-6220. AD - Rehabilitation Sciences Institute, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. LA - eng PT - Journal Article DEP - 20260921 PL - Canada TA - JMIR Rehabil Assist Technol JT - JMIR rehabilitation and assistive technologies JID - 101703412 PMC - PMC13592660 OTO - NOTNLM OT - brain injury OT - concussion OT - group intervention OT - parents OT - pediatrics OT - qualitative OT - rehabilitation OT - telehealth OT - telemedicine OT - virtual care COIS- Conflicts of Interest: None declared. EDAT- 2026/09/21 17:47 MHDA- 2026/09/21 17:48 PMCR- 2026/09/21 CRDT- 2026/09/21 15:52 PHST- 2025/12/01 00:00 [received] PHST- 2026/06/30 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/09/21 17:48 [medline] PHST- 2026/09/21 17:47 [pubmed] PHST- 2026/09/21 15:52 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - v13i1e88771 [pii] AID - 88771 [pii] AID - 10.2196/88771 [doi] PST - epublish SO - JMIR Rehabil Assist Technol. 2026 Sep 21;13:e88771. doi: 10.2196/88771. PMID- 42766722 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260921 LR - 20260923 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 9 DP - 2026 Sep 21 TI - Generative AI Engagement and Perceived Nutrition-Oriented Feeding Practices Among Urban Indonesian Mothers: Mixed Methods Study. PG - e100061 LID - 10.2196/100061 [doi] LID - e100061 AB - BACKGROUND: The Asia-Pacific region faces an escalating double burden of malnutrition, with childhood obesity now affecting more than 113 million children aged 0-19 years. A demographic of highly educated, digitally literate urban mothers-referred to in this study using the descriptive label "Alpha Mother"-increasingly draws on generative AI as a source of toddler nutrition information. Yet, whether this shift empowers or undermines quality feeding practices remains empirically untested. OBJECTIVE: This study examined how generative artificial intelligence (AI) engagement is associated with perceived nutrition-oriented feeding practices among urban Alpha Mothers in Indonesia, with cognitive empowerment and parental self-compassion as intervening variables, and eHealth self-efficacy as a moderator. The study contextually refined 5 AI engagement dimensions, organized through an AI parenting nutrition alignment approach. METHODS: An exploratory sequential mixed methods design was used. Phase 1 comprised semistructured interviews with 10 Alpha Mothers and used hybrid deductive-inductive thematic analysis to contextually refine 5 literature-informed AI engagement constructs: AI algorithmic trust, AI health information quality, AI personalization fit perception, AI information-seeking intensity, and AI social proof sensitivity. These informed a survey instrument developed through the qualitative phase and refined against previously validated scales in phase 2, recruiting 442 respondents across 4 Indonesian urban centers. A 14-hypothesis structural model was tested using PLS-SEM (partial least squares-structural equation modeling). RESULTS: Twelve of 14 hypotheses were supported. The model demonstrated substantial explanatory power for cognitive empowerment (R(2)=0.661) and parental self-compassion (R(2)=0.719), while perceived nutrition-oriented feeding practices yielded a more modest value (R(2)=0.280). This result reflects the multifactorial nature of self-reported nutrition-oriented feeding practices, which is shaped by numerous personal, cultural, and situational factors beyond AI engagement. AI algorithmic trust showed the strongest association with parental self-compassion (beta=.479; P<.001), while AI personalization fit perception most strongly predicted cognitive empowerment (beta=.275; P<.001). Both intervening variables were significantly associated with nutrition-oriented feeding practices, with cognitive empowerment (beta=.232; P=.003) outperforming parental self-compassion (beta=.165; P=.009). eHealth self-efficacy moderated the cognitive empowerment pathway (beta=.124; P=.02) but not the self-compassion pathway. CONCLUSIONS: The findings suggest that generative AI engagement is associated with perceived nutrition-oriented feeding practices via 2 distinct indirect associations examined in this study: cognitive empowerment and parental self-compassion. These associations were strongest when mothers trusted the AI system and perceived its recommendations as fitting their child and household realities, indicating that the perceived value of AI in toddler feeding may lie less in algorithmic sophistication than in its capacity to build trust, fit context, and support maternal judgment. Because the outcome reflects maternal perception rather than observed feeding behavior or child nutrition outcomes, these findings should be interpreted as associational. They may nonetheless inform future research on AI-assisted feeding support that complements, rather than replaces, professional nutrition counseling. CI - (c) Lia Nur Amalina, Ferdi Antonio, Surya Adiwena, Dewi Wuisan, Roy Glenn Massie. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org). FAU - Amalina, Lia Nur AU - Amalina LN AUID- ORCID: 0009-0002-8791-4632 AD - Department of Hospital Administration, Graduate School of Management, Pelita Harapan University, Jl. Garnisun Dalam No. 8, RT 5, RW 4, Karet Semanggi, Jakarta, Jakarta Special Capital Region, 12930, Indonesia, 62 812-1010-676. FAU - Antonio, Ferdi AU - Antonio F AUID- ORCID: 0000-0002-1319-3732 AD - Department of Hospital Administration, Graduate School of Management, Pelita Harapan University, Jl. Garnisun Dalam No. 8, RT 5, RW 4, Karet Semanggi, Jakarta, Jakarta Special Capital Region, 12930, Indonesia, 62 812-1010-676. FAU - Adiwena, Surya AU - Adiwena S AUID- ORCID: 0009-0005-0198-4341 AD - Department of Hospital Administration, Graduate School of Management, Pelita Harapan University, Jl. Garnisun Dalam No. 8, RT 5, RW 4, Karet Semanggi, Jakarta, Jakarta Special Capital Region, 12930, Indonesia, 62 812-1010-676. FAU - Wuisan, Dewi AU - Wuisan D AUID- ORCID: 0000-0001-8550-3659 AD - Department of Hospital Administration, Graduate School of Management, Pelita Harapan University, Jl. Garnisun Dalam No. 8, RT 5, RW 4, Karet Semanggi, Jakarta, Jakarta Special Capital Region, 12930, Indonesia, 62 812-1010-676. FAU - Massie, Roy Glenn AU - Massie RG AUID- ORCID: 0009-0007-9980-8841 AD - Health Policy, National Research and Innovation Agency (BRIN), Jakarta, Indonesia. LA - eng PT - Journal Article DEP - 20260921 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC13592562 OTO - NOTNLM OT - Indonesia OT - cognitive empowerment OT - feeding behavior OT - generative artificial intelligence OT - health literacy OT - mothers OT - parental self-compassion OT - parenting OT - self-efficacy COIS- Conflicts of Interest: None declared. EDAT- 2026/09/21 17:47 MHDA- 2026/09/21 17:48 PMCR- 2026/09/21 CRDT- 2026/09/21 14:43 PHST- 2026/05/02 00:00 [received] PHST- 2026/08/04 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/09/21 17:48 [medline] PHST- 2026/09/21 17:47 [pubmed] PHST- 2026/09/21 14:43 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - v9i1e100061 [pii] AID - 100061 [pii] AID - 10.2196/100061 [doi] PST - epublish SO - JMIR Pediatr Parent. 2026 Sep 21;9:e100061. doi: 10.2196/100061. PMID- 42766014 OWN - NLM STAT- Publisher LR - 20260921 IS - 1433-8491 (Electronic) IS - 0940-1334 (Linking) DP - 2026 Sep 21 TI - Results of the validated German Perceived Stress Questionnaire (PSQ) from a large German cohort of healthy adults and different disease groups compared to historical reference values. LID - 10.1007/s00406-026-02379-8 [doi] AB - BACKGROUND: Reference values of the validated German Perceived Stress Questionnaire (PSQ) were published in 2005 for healthy adults and individuals with different clinical conditions. We compared historical values with PSQ from the large German cohort participating in "Risk Factors for COVID-19 Vaccine Failure study (RisCoin). METHODS: In late 2021, we enrolled 4115 adults: hospital employees or patients with inflammatory bowel disease (IBD) or psychiatric disorders with >/= 2 COVID-19 vaccinations. Participants completed extensive questionnaires including PSQ. Healthcare workers (HCW) were categorized as HCW-healthy or HCW-plus (any chronic medical condition). PSQ total and domain scores (worries, tension, joy, demands) were compared to reference values. Multivariable logistic regression identified factors associated with cohort-specific high scores (mean + 1SD). RESULTS: HCW-healthy (N = 1998, mean age +/- SD: 38 +/- 12 years) reached higher mean total PSQ scores than historical healthy individuals (36 +/- 18 vs. 33 +/- 17, respectively, p<0.001), but lower scores (40 +/- 19, p < 0.001) than HCW-plus (N = 1717, 43 +/- 13 years). Female HCW-healthy perceived higher stress than males, especially at younger age. Participants with IBD (N = 161, 45 +/- 15 years) exhibited lower scores than historical IBD patients (38 +/- 19 vs. 43 +/- 17, p < 0.001); psychiatric patients (N = 100, 41 +/- 15 years) showed the highest scores (60 +/- 19). Among HCW, female gender, frequent consumption of ready-to-eat meals/foods, and living with children were associated with higher, whereas regular physical activity and healthy dietary habits with lower PSQ scores. CONCLUSION: Assuming representativeness of our cohort, these PSQ data could serve as updated benchmark for future research. CI - (c) 2026. The Author(s). FAU - Adorjan, Kristina AU - Adorjan K AD - Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Center for International Health (CIH), LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - University Hospital of Psychiatry and Psychotherapy (UPZ), University of Bern, Bern, Switzerland. FAU - Raffel, Jannis AU - Raffel J AD - Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Zhelyazkova, Ana AU - Zhelyazkova A AUID- ORCID: 0000-0002-8085-5003 AD - Institut fur Notfallmedizin und Medizinmanagement (INM), LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Csollarova, Katarina AU - Csollarova K AD - Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Jebrini, Tarek AU - Jebrini T AD - Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Wratil, Paul R AU - Wratil PR AUID- ORCID: 0000-0003-0942-0637 AD - Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. FAU - Keppler, Oliver T AU - Keppler OT AD - Max von Pettenkofer Institute and Gene Center, Virology, National Reference Center for Retroviruses, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany. FAU - Tuschen, Marina AU - Tuschen M AD - Department of Anaesthesiology, Laboratory of Translational Research Stress and Immunity,LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Koletzko, Leandra AU - Koletzko L AD - Department of Medicine II, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Torok, Helga P AU - Torok HP AD - Department of Medicine II, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Chouker, Alexander AU - Chouker A AD - Department of Anaesthesiology, Laboratory of Translational Research Stress and Immunity,LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Koletzko, Sibylle AU - Koletzko S AD - Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. Sibylle.Koletzko@med.uni-muenchen.de. AD - Department of Pediatrics, Gastroenterology and Nutrition, School of Medicine Collegium Medicum, University of Warmia and Mazury, Olsztyn, Poland. Sibylle.Koletzko@med.uni-muenchen.de. FAU - Le Thi, Thu Giang AU - Le Thi TG AUID- ORCID: 0000-0002-2504-9551 AD - Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. thu_giang.le_thi@med.uni-muenchen.de. AD - Stiftung Kindergesundheit, c/o Dr. von Hauner Children's Hospital, LMU University Hospital, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. thu_giang.le_thi@med.uni-muenchen.de. CN - Members of RisCoin Study Group LA - eng PT - Journal Article DEP - 20260921 PL - Germany TA - Eur Arch Psychiatry Clin Neurosci JT - European archives of psychiatry and clinical neuroscience JID - 9103030 SB - IM OTO - NOTNLM OT - Chronic conditions OT - Collaborative care OT - Prospective study OT - Risk factors OT - Stress COIS- Declarations. Conflict of interest: The authors declare no competing interests. Informed consent statement: All the participants provided written informed consent prior to participation. Institutional review board statement: This study protocol was approved by the Ethics Committee of LMU Munich on September 21, 2021 (Project Number: 21-0839), with acceptance of amendments on February 22, 2022, and May 4, 2022. The data protection concept was approved by the LMU data protection officer on September 15, 2021, and the amendment for the second follow-up was approved on September 8, 2022. Clinical trial registration: "Risk factors for COVID-19 vaccine failure, "RisCoin", MainID: DRKS00026804, http://drks.de/search/en/trial/DRKS00026804 (Accessed on 18.07.2025). FIR - Osterman, A IR - Osterman A FIR - Badell Garcia, I IR - Badell Garcia I FIR - Huber, M IR - Huber M FIR - Wratil, P R IR - Wratil PR FIR - Adorjan, K IR - Adorjan K FIR - Gryaznova, A IR - Gryaznova A FIR - Jebrini, T IR - Jebrini T FIR - Kohl, P IR - Kohl P FIR - Jonge, S IR - Jonge S FIR - Neumeier, K IR - Neumeier K FIR - Koletzko, S IR - Koletzko S FIR - Koletzko, B IR - Koletzko B FIR - Kim-Helmuth, S IR - Kim-Helmuth S FIR - Hao, Y IR - Hao Y FIR - Horak, J IR - Horak J FIR - Le Thi, T G IR - Le Thi TG FIR - Puzek, B IR - Puzek B FIR - Schwerd, T IR - Schwerd T FIR - Torok, H P IR - Torok HP FIR - Koletzko, L IR - Koletzko L FIR - Breiteneicher, S IR - Breiteneicher S FIR - Csollarova, K IR - Csollarova K FIR - Chouker, A IR - Chouker A FIR - Tuschen, M IR - Tuschen M FIR - Biere, K IR - Biere K FIR - Wohrle, T IR - Wohrle T FIR - Matzel, S IR - Matzel S FIR - Horl, M IR - Horl M FIR - Moser, D IR - Moser D FIR - Hornung, V IR - Hornung V FIR - Rech, J IR - Rech J FIR - Ludwig, C IR - Ludwig C FIR - Hansbauer, L IR - Hansbauer L FIR - Zhelyazkova, A IR - Zhelyazkova A FIR - Klein, M IR - Klein M FIR - Volk, S IR - Volk S EDAT- 2026/09/21 17:47 MHDA- 2026/09/21 17:47 CRDT- 2026/09/21 11:04 PHST- 2026/03/26 00:00 [received] PHST- 2026/09/06 00:00 [accepted] PHST- 2026/09/21 17:47 [medline] PHST- 2026/09/21 17:47 [pubmed] PHST- 2026/09/21 11:04 [entrez] AID - 10.1007/s00406-026-02379-8 [pii] AID - 10.1007/s00406-026-02379-8 [doi] PST - aheadofprint SO - Eur Arch Psychiatry Clin Neurosci. 2026 Sep 21. doi: 10.1007/s00406-026-02379-8. PMID- 42765914 OWN - NLM STAT- Publisher LR - 20260921 IS - 1558-9129 (Electronic) IS - 0161-1461 (Linking) DP - 2026 Sep 21 TI - Children's Rights to the Best Possible Care: Establishing Processes for Data Collection in Routine Care to Address Questions of Intervention Effectiveness for Children With Speech Sound Disorder. PG - 1-10 LID - 10.1044/2026_LSHSS-25-00202 [doi] AB - PURPOSE: The United Nations Convention of the Rights of the Child (CRC) recognizes that all children have a right to the best possible care, CRC Article 24 (health, water, food, environment). For children with speech sound disorder, this is vital in order to protect their rights to CRC Article 13 (sharing thoughts freely), CRC Article 19 (protection from violence), and CRC Article 28 (access to education). Determining what constitutes best possible care for this population is challenging because much evidence for intervention takes place outside of routine care. This review article provides an overview of Phase 1 of the Maximising the Impact of Speech and Language Therapy for Children with Speech Sound Disorder (MISLToe_SSD) program of research, which ultimately aims to establish a process for using data collected in routine care to investigate best possible care for children with speech sound disorder. The purpose of Phase 1 was to obtain consensus on a diagnostic pathway, a defined list of interventions, and a core outcome set. METHOD AND RESULTS: An umbrella review was carried out to provide information on existing evidence. Participatory workshops with speech and language therapists were used to determine the content of the diagnostic pathway, and a card sorting exercise was used to provide a list of interventions currently in use and agree on their definitions. Finally, the core outcome set was agreed through a Delphi process. Patient and public involvement activities were used throughout the program of work to ensure that the aims and activities were in line with the preferences of those with lived experience of speech sound disorder. CONCLUSIONS: Consensus was reached on the three core aims of agreeing a diagnostic protocol, a core outcome set, and a list of defined interventions. Phase 2 of MISLToe_SSD will establish the feasibility of implementing these within routine care, and Phase 3 will extend the work to multiple services, leading to the large data set required for future analyses. This work has been carried out in the United Kingdom, but work is underway to replicate this work in Brazil, Sweden, Portugal, and other countries and in other languages to establish an international diagnostic pathway, a defined list of interventions, and a core outcome set. FAU - Wren, Yvonne AU - Wren Y AUID- ORCID: 0000-0002-1575-453X AD - Bristol Speech & Language Therapy Research Unit, North Bristol NHS Trust, Southmead Hospital, Bristol, United Kingdom. AD - Cardiff School of Sport & Health Sciences, Cardiff Metropolitan University, Llandaff Campus, Wales, United Kingdom. AD - Bristol Dental School, University of Bristol, United Kingdom. FAU - Burr, Sam AU - Burr S AD - Bristol Speech & Language Therapy Research Unit, North Bristol NHS Trust, Southmead Hospital, Bristol, United Kingdom. AD - Cardiff School of Sport & Health Sciences, Cardiff Metropolitan University, Llandaff Campus, Wales, United Kingdom. FAU - Cleland, Joanne AU - Cleland J AUID- ORCID: 0000-0002-0660-1646 AD - Department of Psychological Sciences & Health, University of Strathclyde, Glasgow, Scotland. FAU - Stringer, Helen AU - Stringer H AD - King George VI Building, Newcastle University, Newcastle upon Tyne, United Kingdom. FAU - Harding, Sam AU - Harding S AD - Bristol Speech & Language Therapy Research Unit, North Bristol NHS Trust, Southmead Hospital, Bristol, United Kingdom. AD - Department of Research & Development, North Bristol NHS Trust, United Kingdom. LA - eng PT - Journal Article DEP - 20260921 PL - United States TA - Lang Speech Hear Serv Sch JT - Language, speech, and hearing services in schools JID - 0323431 SB - IM EDAT- 2026/09/21 11:44 MHDA- 2026/09/21 11:44 CRDT- 2026/09/21 10:23 PHST- 2026/09/21 11:44 [medline] PHST- 2026/09/21 11:44 [pubmed] PHST- 2026/09/21 10:23 [entrez] AID - 10.1044/2026_LSHSS-25-00202 [doi] PST - aheadofprint SO - Lang Speech Hear Serv Sch. 2026 Sep 21:1-10. doi: 10.1044/2026_LSHSS-25-00202. PMID- 42765528 OWN - NLM STAT- Publisher LR - 20261014 IS - 1744-8379 (Electronic) IS - 1473-7167 (Print) IS - 1473-7167 (Linking) DP - 2026 Sep 22 TI - Obstetric pharmacoeconomics. PG - 1-16 LID - 10.1080/14737167.2026.2738026 [doi] AB - INTRODUCTION: Pharmacoeconomic principles are increasingly shaping modern obstetric pharmacology as maternal therapeutics become more complex, costly, and precision-driven. Rising rates of hypertensive disorders of pregnancy, gestational diabetes, obesity, maternal cardiovascular disease, and medically complicated pregnancies have intensified the need for cost-effective therapeutic strategies that optimize maternal and neonatal outcomes while minimizing unnecessary healthcare expenditure. AREAS COVERED: This review examines contemporary pharmacoeconomic concepts in obstetric pharmacology, including cost-effectiveness analysis, quality-adjusted life years, implementation science, and value-based maternal therapeutics. Major domains reviewed include antihypertensive therapy, aspirin prophylaxis, diabetes pharmacotherapy, antiretroviral therapy in pregnancy, anticoagulation, perinatal mental health, lactation, fetal therapeutics, pharmacogenomics, precision dosing, digital health integration, and emerging artificial intelligence applications in maternal fetal medicine. The review further explores linked maternal-child outcome modeling, implementation-sensitive economic evaluation, and the growing role of pharmacometrics and biomarker-guided therapeutics in precision pregnancy care. The review also proposes a life-course framework linking pregnancy therapeutics to inter-generational health, implementation outcomes, and sustainable maternal healthcare systems globally. EXPERT OPINION: Obstetric pharmacology is entering a precision-medicine era where therapeutic value will depend on biologic profiling, implementation feasibility, and long-term maternal-child outcomes. Future pharmacoeconomic frameworks should integrate precision therapeutics, biomarker-guided strategies, real-world effectiveness, and lifelong maternal cardiovascular risk reduction. FAU - Eke, Ahizechukwu C AU - Eke AC AUID- ORCID: 0000-0002-0070-9840 AD - Division of Maternal Fetal-Medicine, Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. AD - Masters in Business Administration (MBA Program in Healthcare Administration), Department of Business Administration, University of South Carolina, Aiken, CA, USA. FAU - Igbodike, Emeka P AU - Igbodike EP AD - Department of Obstetrics and Gynaecology, Lagos University Teaching Hospital (LUTH), Lagos, Nigeria. LA - eng GR - DP1 HD115433/HD/NICHD NIH HHS/United States GR - R01 HL182418/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Review DEP - 20260922 PL - England TA - Expert Rev Pharmacoecon Outcomes Res JT - Expert review of pharmacoeconomics & outcomes research JID - 101132257 SB - IM PMC - PMC13657845 MID - NIHMS2212086 OTO - NOTNLM OT - Pharmacoeconomics OT - cost-effectiveness OT - drug safety OT - implementation science OT - maternal-fetal medicine OT - obstetric pharmacology OT - precision medicine OT - pregnancy COIS- Declaration of interests The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. The authors declare that OpenAI ChatGPT (GPT-5.6 Sol) was used solely to assist with editing the presentation of our original figures. Generative AI was not used to write or edit the manuscript or to generate the figures. The authors independently reviewed and verified all AI-assisted figure edits and take full responsibility for the final content. All use of generative AI was conducted in accordance with Taylor & Francis' policy on the responsible use of generative AI. EDAT- 2026/09/21 11:44 MHDA- 2026/09/21 11:44 PMCR- 2026/10/13 CRDT- 2026/09/21 07:14 PHST- 2026/09/21 11:44 [pubmed] PHST- 2026/09/21 11:44 [medline] PHST- 2026/09/21 07:14 [entrez] PHST- 2026/10/13 00:00 [pmc-release] AID - 10.1080/14737167.2026.2738026 [doi] PST - aheadofprint SO - Expert Rev Pharmacoecon Outcomes Res. 2026 Sep 22:1-16. doi: 10.1080/14737167.2026.2738026. PMID- 42764933 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260921 LR - 20260922 IS - 2211-3355 (Print) IS - 2211-3355 (Electronic) IS - 2211-3355 (Linking) VI - 71 DP - 2026 Nov TI - Analysis of the current status and correlates of knowledge-attitude-practice (KAP) regarding cardiovascular and cerebrovascular diseases (CCVD) in adolescents and young adults. PG - 103615 LID - 10.1016/j.pmedr.2026.103615 [doi] LID - 103615 AB - OBJECTIVE: To investigate knowledge-attitude-practice (KAP) regarding cardiovascular and cerebrovascular diseases (CCVD) among adolescents and young adults, and to identify associated factors to provide evidence for targeted prevention. METHODS: A cross-sectional survey was conducted through digital platforms from August to October 2025, recruiting 636 participants from North, East and Southwest China through convenience sampling. Data were collected via a self-designed CCVD KAP questionnaire, S-CVI was 0.93, and Cronbach's alpha was 0.92. The data were analyzed using SPSS 27.0. RESULTS: The overall KAP score was (74.90 +/- 20.83), with a scoring rate 63.47%. Among the three dimensions, the attitude subscale scored the highest, followed by knowledge and practice. Multiple linear regression analysis showed that the total score positively correlated with female gender, better self-rated health, and overweight; negatively with East and Southwest China residence, higher-maternal education, and unknown family history. For knowledge and attitude, exercise and sleep were positively correlated, smoking and drinking negatively. Higher education positively correlated with knowledge and attitude but negatively with practice. CONCLUSION: Awareness of CCVD was moderate, with positive attitude but suboptimal behavioral adherence. These findings support targeted interventions to address the knowledge-practice gap, particularly among those with low education, unhealthy lifestyles, or uncertain family history. CI - (c) 2026 The Authors. Published by Elsevier Inc. FAU - Sun, Tongyan AU - Sun T AD - School of Nursing, Tianjin Medical University, Tianjin 300070, China. FAU - Zhang, Hua AU - Zhang H AD - School of Nursing, Tianjin Medical University, Tianjin 300070, China. LA - eng PT - Journal Article DEP - 20260910 PL - United States TA - Prev Med Rep JT - Preventive medicine reports JID - 101643766 PMC - PMC13590049 OTO - NOTNLM OT - Adolescents OT - Cardiovascular and cerebrovascular diseases (CCVD) OT - Knowledge-attitude-practice (KAP) OT - Young adults COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/21 05:34 MHDA- 2026/09/21 05:35 PMCR- 2026/09/10 CRDT- 2026/09/21 03:42 PHST- 2026/04/13 00:00 [received] PHST- 2026/08/26 00:00 [revised] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/09/21 05:35 [medline] PHST- 2026/09/21 05:34 [pubmed] PHST- 2026/09/21 03:42 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - S2211-3355(26)00243-3 [pii] AID - 103615 [pii] AID - 10.1016/j.pmedr.2026.103615 [doi] PST - epublish SO - Prev Med Rep. 2026 Sep 10;71:103615. doi: 10.1016/j.pmedr.2026.103615. eCollection 2026 Nov. PMID- 42764707 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20260923 IS - 1520-6300 (Electronic) IS - 1042-0533 (Print) IS - 1042-0533 (Linking) VI - 38 IP - 9 DP - 2026 Sep TI - Sleep Duration and Sun Exposure in Portuguese Children: Associations With Obesity Indicators. PG - e70333 LID - 10.1002/ajhb.70333 [doi] LID - e70333 AB - INTRODUCTION: Sleep duration, sun exposure, and obesity are important and potentially interconnected factors in child health. In this study, we aimed to analyze the associations between sleep duration, sun exposure, and obesity indicators in Portuguese children. METHODS: This cross-sectional study included 4755 children aged 3-10 years from public and private schools across Portugal. Parents reported children's sleep duration, sun exposure, screen time, active play, and physical activity using validated questionnaires. Trained professionals measured weight and height to calculate Body Mass Index (BMI) and assessed skinfold thickness to estimate body fat percentage (%BF). Multiple linear regression analyses, stratified by sex and adjusted for demographic, behavioral, and anthropometric factors, analyzed associations between sun exposure and sleep duration. RESULTS: In partially adjusted models (Model 1), negative associations persisted among boys, and positive associations emerged in girls for average sleep duration (beta = 2.11; 95% CI: 0.25 to 3.96; p = 0.026) and weekdays (beta = 2.40; 95% CI: 0.47 to 4.33; p = 0.015). In fully adjusted models (Model 2), the negative association remained only for boys on Sundays (beta = -4.57; 95% CI: -8.22 to -0.91; p = 0.014), with no significant associations in girls. CONCLUSIONS: Sun exposure exhibits modest, sex-specific associations with sleep duration in children. These findings emphasize the importance of considering behavioral and environmental factors when designing interventions to promote healthy sleep, support growth, and prevent childhood obesity. CI - (c) 2026 The Author(s). American Journal of Human Biology published by Wiley Periodicals LLC. FAU - Dos Santos, Elizabete A AU - Dos Santos EA AUID- ORCID: 0000-0001-9201-4095 AD - Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. AD - Department of Nutrition, Paulista School of Medicine (EPM) of the Federal University of Sao Paulo (Unifesp), Sao Paulo, Brazil. FAU - Machado-Rodrigues, Aristides AU - Machado-Rodrigues A AUID- ORCID: 0000-0002-7169-8034 AD - Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. AD - Faculty of Sport Sciences and Physical Education, University of Coimbra, Coimbra, Portugal. FAU - Rodrigues, Daniela AU - Rodrigues D AUID- ORCID: 0000-0002-4559-4303 AD - Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. FAU - Silva, Maria-Raquel G AU - Silva MG AUID- ORCID: 0000-0001-8170-3119 AD - Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. AD - FP-I3ID, FP-BHS, CEBIMED and Faculty of Health Sciences, University Fernando Pessoa, Porto, Portugal. AD - Comprehensive Health Research Centre, Nova Medical School, Nova University of Lisbon, Lisbon, Portugal. FAU - Nogueira, Helena AU - Nogueira H AUID- ORCID: 0000-0001-5724-3538 AD - Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. AD - Department of Geography and Tourism, University of Coimbra, Coimbra, Portugal. FAU - Padez, Cristina AU - Padez C AUID- ORCID: 0000-0002-1967-3497 AD - Research Centre for Anthropology and Health, Department of Life Sciences, University of Coimbra, Coimbra, Portugal. LA - eng GR - PTDC/DTP-SAP/1520/2014/Fundacao para a Ciencia e a Tecnologia/ GR - COMPETE 2020, Portugal 2020, FEDER, and FCT/ PT - Journal Article PL - United States TA - Am J Hum Biol JT - American journal of human biology : the official journal of the Human Biology Council JID - 8915029 SB - IM MH - Humans MH - Portugal/epidemiology MH - *Sleep Duration MH - Male MH - Child MH - Female MH - Cross-Sectional Studies MH - Child, Preschool MH - *Sunlight MH - *Pediatric Obesity/epidemiology/etiology MH - *Sleep PMC - PMC13591200 OTO - NOTNLM OT - childhood obesity OT - children OT - pediatric public health OT - sleep duration OT - sun exposure COIS- The authors used ChatGPT (OpenAI) solely to assist with English-language editing and grammatical review. The tool was not used for data collection, data analysis, statistical procedures, interpretation of the findings, or generation of scientific conclusions. All AI-assisted revisions were critically reviewed and verified by the authors to ensure their accuracy, integrity, and consistency with the original scientific content. The authors take full responsibility for the final content of the manuscript. The authors declare no conflicts of interest. EDAT- 2026/09/21 05:34 MHDA- 2026/09/21 05:35 PMCR- 2026/09/21 CRDT- 2026/09/21 03:03 PHST- 2026/08/31 00:00 [revised] PHST- 2026/07/23 00:00 [received] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/09/21 05:35 [medline] PHST- 2026/09/21 05:34 [pubmed] PHST- 2026/09/21 03:03 [entrez] PHST- 2026/09/21 00:00 [pmc-release] AID - AJHB70333 [pii] AID - 10.1002/ajhb.70333 [doi] PST - ppublish SO - Am J Hum Biol. 2026 Sep;38(9):e70333. doi: 10.1002/ajhb.70333. PMID- 42764592 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20260921 IS - 1520-6300 (Electronic) IS - 1042-0533 (Linking) VI - 38 IP - 9 DP - 2026 Sep TI - Comparison of External Measurement Methods of the 2D:4D Digit Ratio. PG - e70337 LID - 10.1002/ajhb.70337 [doi] AB - OBJECTIVES: External methods for measuring digit length differ in the hand surface and anatomical landmarks used, but the comparability of resulting 2D:4D ratios is unclear. This study compared 2D:4D ratios obtained using four external measurement methods and evaluated between-method differences, correlations, and reliability. METHODS: Digit lengths were measured in 231 Turkish university students (103 males, 128 females). Measurements were obtained directly with calipers from the dorsal and ventral surfaces and indirectly from photocopies and photographs. The 2D:4D ratio was calculated as second-digit length divided by fourth-digit length. Right and left hands were analyzed separately for effects of measurement method, sex, and hand side. RESULTS: Males had lower 2D:4D ratios than females for all methods and hand sides except direct dorsal measurement of the left hand. Mean ratios were lowest with direct dorsal measurement and highest with direct ventral measurement. Differences among methods were significant for both hands (p < 0.001). Between-method correlations ranged from r = 0.529-0.771 for the right hand and r = 0.440-0.776 for the left hand (all p < 0.001). Intraobserver and interobserver reliability in the pilot sample was high (ICC = 0.85-0.95). CONCLUSIONS: The 2D:4D ratio varies systematically according to the external measurement method used. Measurement protocols should therefore be reported explicitly, and absolute 2D:4D values obtained using different methods should be compared cautiously. These findings highlight the importance of standardizing measurement methods in 2D:4D research and suggest that the detection of sex differences may vary according to both the measurement method and hand side. CI - (c) 2026 Wiley Periodicals LLC. FAU - Collu, Ilknur AU - Collu I AUID- ORCID: 0000-0003-1605-6327 AD - Faculty of Medicine, Department of Anatomy, Izmir Katip Celebi University, Izmir, Turkiye. FAU - Malas, Mehmet Ali AU - Malas MA AUID- ORCID: 0000-0002-1451-0672 AD - Faculty of Medicine, Department of Anatomy, Izmir Katip Celebi University, Izmir, Turkiye. LA - eng GR - 2025-TDU-TIPF-0002/Scientific Research Projects Coordination Unit of Izmir Katip Celebi University/ PT - Comparative Study PT - Journal Article PL - United States TA - Am J Hum Biol JT - American journal of human biology : the official journal of the Human Biology Council JID - 8915029 SB - IM MH - Humans MH - Male MH - Female MH - *Fingers/anatomy & histology MH - Reproducibility of Results MH - *Anthropometry/methods MH - Young Adult MH - Turkey MH - *Digit Ratios MH - Adult MH - Adolescent OTO - NOTNLM OT - 2D:4D OT - digit ratio OT - direct measurement OT - dorsal surface OT - indirect measurement OT - measurement method OT - ventral surface EDAT- 2026/09/21 05:34 MHDA- 2026/09/21 05:35 CRDT- 2026/09/21 02:24 PHST- 2026/09/09 00:00 [revised] PHST- 2026/08/11 00:00 [received] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/09/21 05:35 [medline] PHST- 2026/09/21 05:34 [pubmed] PHST- 2026/09/21 02:24 [entrez] AID - 10.1002/ajhb.70337 [doi] PST - ppublish SO - Am J Hum Biol. 2026 Sep;38(9):e70337. doi: 10.1002/ajhb.70337. PMID- 42764227 OWN - NLM STAT- MEDLINE DCOM- 20260920 LR - 20260923 IS - 2045-7634 (Electronic) IS - 2045-7634 (Linking) VI - 15 IP - 9 DP - 2026 Sep TI - Development and Validation of an Interpretable Machine Learning Model for Predicting Early Pulmonary Metastasis Risk in Osteosarcoma. PG - e72209 LID - 10.1002/cam4.72209 [doi] LID - e72209 AB - INTRODUCTION: Pulmonary metastasis in high-grade conventional osteosarcoma remains a leading cause of treatment failure and mortality. Traditional monitoring methods are insufficient for early detection. This study aims to develop and validate an interpretable machine learning (ML) model using multi-dimensional data from electronic medical records (EMR) to predict the early risk of pulmonary metastasis in high-grade conventional osteosarcoma patients. METHODS: This retrospective study included data from 522 high-grade conventional osteosarcoma patients. After rigorous feature selection, 12 independent predictive factors were identified: prothrombin time (PT), international normalized ratio (INR), fibrinogen, globulin, prognostic nutritional index (PNI), eosinophil percentage, monocyte percentage, neutrophil percentage, monocyte count, maximum tumor diameter, gender, and amputation status. Eleven ML models were constructed and compared, with Shapley Additive Explanations (SHAP) analysis applied to enhance model interpretability and clinical transparency. RESULTS: The gradient boosting model exhibited superior performance, achieving an area under the curve (AUC) of 0.891 in the training set and 0.742 in the independent test set. SHAP analysis revealed that tumor maximum diameter was the most influential predictor of pulmonary metastasis risk, while inflammation and coagulation-related indicators also demonstrated significant contributions. DISCUSSION: The gradient boosting model effectively predicts the early risk of pulmonary metastasis in high-grade conventional osteosarcoma and provides interpretable risk factors. This model shows potential as a clinical decision support tool, facilitating personalized risk management and precision medicine, aiming to improve patient outcomes. CI - (c) 2026 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd. FAU - Mu, Jianhua AU - Mu J AUID- ORCID: 0000-0002-0983-4605 AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. AD - Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Wang, Yitian AU - Wang Y AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. AD - Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Liu, Han AU - Liu H AUID- ORCID: 0009-0002-2523-6151 AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. FAU - He, Xuanhong AU - He X AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. FAU - Li, Zhuangzhuang AU - Li Z AUID- ORCID: 0009-0002-0004-5455 AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. FAU - Luo, Yi AU - Luo Y AUID- ORCID: 0000-0003-4470-220X AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. AD - Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Zhou, Yong AU - Zhou Y AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. AD - Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Lu, Minxun AU - Lu M AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. AD - Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Tang, Fan AU - Tang F AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. AD - Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Min, Li AU - Min L AUID- ORCID: 0009-0006-7792-5708 AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. AD - Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Tu, Chongqi AU - Tu C AUID- ORCID: 0000-0002-1045-9742 AD - Department of Orthopedics, Orthopeadic Research Institute, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, China. AD - Model Worker and Craftsman Talent Innovation Workshop of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan, China. LA - eng GR - 82302690/Natural Science Foundation of China/ PT - Journal Article PT - Validation Study PL - United States TA - Cancer Med JT - Cancer medicine JID - 101595310 SB - IM MH - Humans MH - *Osteosarcoma/pathology MH - *Lung Neoplasms/secondary/diagnosis MH - Female MH - *Bone Neoplasms/pathology MH - Predictive Learning Models MH - Retrospective Studies MH - *Machine Learning MH - Male MH - Prognosis MH - Boosting Machine Learning Algorithms MH - Risk Factors MH - Adult MH - Adolescent MH - Young Adult MH - Prediction Algorithms MH - Risk Assessment PMC - PMC13590279 OTO - NOTNLM OT - EMR OT - machine learning OT - osteosarcoma OT - predictive model OT - pulmonary metastasis COIS- The authors declare no conflicts of interest. EDAT- 2026/09/20 23:34 MHDA- 2026/09/20 23:35 PMCR- 2026/09/20 CRDT- 2026/09/20 21:43 PHST- 2026/07/27 00:00 [revised] PHST- 2026/01/16 00:00 [received] PHST- 2026/08/18 00:00 [accepted] PHST- 2026/09/20 23:35 [medline] PHST- 2026/09/20 23:34 [pubmed] PHST- 2026/09/20 21:43 [entrez] PHST- 2026/09/20 00:00 [pmc-release] AID - CAM472209 [pii] AID - 10.1002/cam4.72209 [doi] PST - ppublish SO - Cancer Med. 2026 Sep;15(9):e72209. doi: 10.1002/cam4.72209. PMID- 42763700 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260920 LR - 20260921 IS - 1726-9148 (Electronic) IS - 1726-913X (Print) IS - 1726-913X (Linking) VI - 24 IP - 2 DP - 2026 Apr 30 TI - Subclinical Diastolic Indices in Children with Type 1 Diabetes: A Cross-Sectional Comparative Study from Northern Iran. PG - e164686 LID - 10.5812/ijem-164686 [doi] LID - e164686 AB - BACKGROUND: Type 1 diabetes mellitus (T(1)DM) is common and can cause cardiac complications. Subclinical myocardial involvement, particularly impaired diastolic function, is a concern in pediatric patients with T(1)DM. OBJECTIVES: This study aimed to assess cardiac function, with a particular focus on diastolic indices, in children with T(1)DM. METHODS: In this cross-sectional comparative study, children aged 6 - 12 years were divided into two groups: a case group with T(1)DM and a control group of healthy children. Participants were recruited in 2023 from the Endocrinology Clinic at Amirkola Children's Hospital, Babol, Iran. All children underwent clinical evaluation, pubertal status assessment using the Marshall-Tanner criteria, electrocardiography, and echocardiography. RESULTS: A total of 150 children were included, comprising 50 children with T(1)DM and 100 controls. Overall, 52% of the participants were boys, and the mean age was 9.28 +/- 1.85 years. Late diastolic tissue velocity (A') was significantly higher in the T(1)DM group (P = 0.02), suggesting subclinical diastolic impairment. However, most other cardiac parameters, including all systolic indices, ejection fraction, fractional shortening, and electrocardiographic findings, were comparable between the groups (all P > 0.4). The T(1)DM group also had higher mean weight, height, body mass index, and body mass index percentiles (all P < 0.05). CONCLUSIONS: Children with T(1)DM exhibited subtle diastolic dysfunction, reflected by elevated A', whereas systolic function and other cardiac parameters were comparable with those in controls. Given the cross-sectional design, limited sample size, and potential confounding by body mass index and selection bias, these findings should be interpreted cautiously. The standardized single-center methodology supports internal validity; however, multicenter longitudinal studies with larger, z-score-adjusted samples are needed to confirm these results and clarify their clinical implications. CI - Copyright (c) 2026, Rezvani et al. FAU - Rezvani, Atoosa AU - Rezvani A AUID- ORCID: 0009-0006-8083-2203 AD - Student Research Committee, Babol University of Medical Sciences, Babol, Iran. FAU - Mirzaei Ilali, Hamidreza AU - Mirzaei Ilali H AUID- ORCID: 0000-0001-5238-2811 AD - Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, Iran. FAU - Ebrahimzade, Hadis AU - Ebrahimzade H AUID- ORCID: 0000-0003-0649-7268 AD - Clinical Research Development Unit of Amirkola Children's Hospital, Babol University of Medical Sciences, Babol, Iran. FAU - Gholinia Ahangar, Hemmat AU - Gholinia Ahangar H AUID- ORCID: 0000-0003-0517-2429 AD - Health Research Institute, Babol University of Medical Sciences, Babol, Iran. FAU - Aghajanpour, Faeze AU - Aghajanpour F AUID- ORCID: 0000-0002-1698-6906 AD - Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. FAU - Alijanpour, Morteza AU - Alijanpour M AUID- ORCID: 0000-0002-0031-4718 AD - Non-Communicable Pediatric Diseases Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran. LA - eng PT - Journal Article DEP - 20260424 PL - Netherlands TA - Int J Endocrinol Metab JT - International journal of endocrinology and metabolism JID - 101235597 PMC - PMC13589466 OTO - NOTNLM OT - Cardiovascular Disease OT - Child OT - Echocardiography OT - Iran OT - Type 1 Diabetes Mellitus COIS- There was no conflict of interest EDAT- 2026/09/20 05:43 MHDA- 2026/09/20 05:44 PMCR- 2026/04/24 CRDT- 2026/09/20 03:59 PHST- 2025/07/21 00:00 [received] PHST- 2026/02/17 00:00 [revised] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/09/20 05:44 [medline] PHST- 2026/09/20 05:43 [pubmed] PHST- 2026/09/20 03:59 [entrez] PHST- 2026/04/24 00:00 [pmc-release] AID - 10.5812/ijem-164686 [doi] PST - epublish SO - Int J Endocrinol Metab. 2026 Apr 24;24(2):e164686. doi: 10.5812/ijem-164686. eCollection 2026 Apr 30. PMID- 42763564 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260920 LR - 20260921 IS - 2090-6803 (Print) IS - 2090-6811 (Electronic) IS - 2090-6811 (Linking) VI - 2026 DP - 2026 TI - Managing Drug-Resistant Epilepsy and Severe Feeding Difficulties in Miller-Dieker Syndrome: The Role of Enteral Ketogenic Diet. PG - 8660691 LID - 10.1155/crpe/8660691 [doi] LID - 8660691 AB - Miller-Dieker syndrome (MDS) is a rare genetic disorder characterized by classical lissencephaly, severe neurodevelopmental impairment, and early-onset drug-resistant epilepsy. Feeding difficulties and aspiration pneumonia significantly contribute to morbidity and mortality. Evidence regarding ketogenic diet (KD) therapy in patients with severe neurological impairment requiring exclusive enteral nutrition is limited. We report the case of an infant with MDS and pharmacoresistant epilepsy complicated by severe feeding intolerance and recurrent aspiration pneumonia. KD was initiated via postpyloric enteral feeding and subsequently administered through percutaneous endoscopic jejunostomy using a low ketogenic ratio (1.25:1). The diet was well tolerated and associated with seizure freedom maintained until the child's death from an unrelated surgical complication (volvulus), improved nutritional status, and several months of clinical stability. This case highlights the feasibility of enteral KD therapy as part of a multidisciplinary, palliative-oriented approach for managing drug-resistant epilepsy in children with MDS. CI - Copyright (c) 2026 Perrone Michela et al. Case Reports in Pediatrics published by John Wiley & Sons Ltd. FAU - Michela, Perrone AU - Michela P AUID- ORCID: 0000-0002-1318-7922 AD - Neonatal Intensive Care Unit Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, policlinico.mi.it. FAU - Matteo, Porro AU - Matteo P AD - Paediatric Physical Medicine & Rehabilitation Service, Neonatal Intensive Care Unit Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, policlinico.mi.it. FAU - Pasqua, Piemontese AU - Pasqua P AD - Neonatal Intensive Care Unit Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, policlinico.mi.it. FAU - Paola, Roggero AU - Paola R AUID- ORCID: 0000-0003-2667-4620 AD - Neonatal Intensive Care Unit Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, policlinico.mi.it. FAU - Silvana, Gangi AU - Silvana G AD - Neonatal Intensive Care Unit Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, policlinico.mi.it. FAU - Monica, Fumagalli AU - Monica F AD - Neonatal Intensive Care Unit Milan, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy, policlinico.mi.it. AD - Department of Clinical Sciences and Community Health Milan, University of Milan, Lombardy, Milan, Italy, unimi.it. LA - eng PT - Journal Article DEP - 20260918 PL - United States TA - Case Rep Pediatr JT - Case reports in pediatrics JID - 101581030 PMC - PMC13589161 OTO - NOTNLM OT - developmental disability OT - ketogenic diet OT - pediatric OT - seizures COIS- The authors declare no conflicts of interest. EDAT- 2026/09/20 05:43 MHDA- 2026/09/20 05:44 PMCR- 2026/09/18 CRDT- 2026/09/20 03:52 PHST- 2026/03/12 00:00 [received] PHST- 2026/08/12 00:00 [revised] PHST- 2026/09/03 00:00 [accepted] PHST- 2026/09/20 05:44 [medline] PHST- 2026/09/20 05:43 [pubmed] PHST- 2026/09/20 03:52 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - CRPE8660691 [pii] AID - 10.1155/crpe/8660691 [doi] PST - epublish SO - Case Rep Pediatr. 2026 Sep 18;2026:8660691. doi: 10.1155/crpe/8660691. eCollection 2026. PMID- 42763449 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260920 LR - 20260921 IS - 2732-5121 (Electronic) IS - 2732-5121 (Linking) VI - 5 DP - 2025 TI - Moderate and vigorous physical activity show intensity specific familial and interpersonal association patterns in 9-12-year-olds: A cross-sectional DE-PASS study. PG - 331 LID - 10.12688/openreseurope.21538.4 [doi] LID - 331 AB - BACKGROUND: Research on children's physical activity often examines interpersonal associations but commonly aggregates MPA and VPA into a single MVPA outcome. This approach may obscure intensity-specific association patterns, particularly in intergenerational analyses. METHODS: This cross-sectional study used harmonized data from the European DE-PASS project, including children aged 9-12 years and one of their parents. Waist-worn accelerometry was used to assess MPA and VPA. Perceived parental, peer, and teacher support were measured using validated questionnaires. Intensity-specific associations between parent and child physical activity and between interpersonal support variables and children's activity were examined, including sex-stratified and socioeconomic sensitivity analyses. RESULTS: Parent-child associations differed by activity intensity. Parent-child resemblance was numerically larger for MPA than for VPA, although the difference between intensities was not statistically significant when formally compared; associations involving VPA were weaker and less consistent. Parental co-participation support showed a weak positive association (which did not survive correction for multiple testing) with children's MPA, whereas peer and teacher support showed limited or no associations with children's activity at either intensity. Sex-stratified analyses indicated similar MPA associations across boys and girls, while associations for VPA were not observed among girls. Aggregating MPA and VPA into MVPA may obscure these intensity-specific patterns. CONCLUSIONS: These findings indicate that interpersonal associations with children's physical activity differ by intensity and support examining MPA and VPA as intensity-specific outcomes in intergenerational analyses. Family-based approaches focusing on MPA may represent a pausible direction for future longitudinal and intervention research, while different strategies may be needed to address VPA. CI - Copyright: (c) 2026 Ferreira F et al. FAU - Ferreira, Flavio AU - Ferreira F AUID- ORCID: 0009-0001-0336-5561 AD - Lusofona University of Humanities and Technologies Faculty of Physical Education and Sport, Lisbon, Lisbon, Portugal. FAU - Dowd, Kieran AU - Dowd K AD - Department of Sport and Health Sciences, Technological University of the Shannon Midlands Midwest Faculty of Science and Health, Athlone, County Westmeath, Ireland. FAU - Coffey, Alan AU - Coffey A AD - Department of Sport and Health Sciences, Technological University of the Shannon Midlands Midwest Faculty of Science and Health, Athlone, County Westmeath, Ireland. FAU - Cardon, Greet AU - Cardon G AUID- ORCID: 0000-0003-4983-6557 AD - Department of Movement and Sports Sciences, Ghent University Faculty of Medicine and Health Sciences, Ghent, Flanders, Belgium. FAU - Iliano, Evelien AU - Iliano E AUID- ORCID: 0000-0002-8858-8333 AD - Department of Movement and Sports Sciences, Ghent University Faculty of Medicine and Health Sciences, Ghent, Flanders, Belgium. FAU - Dygryn, Jan AU - Dygryn J AD - Palacky University Olomouc Faculty of Physical Culture, Olomouc, Olomouc Region, Czech Republic. FAU - Pelclova, Jana AU - Pelclova J AD - Palacky University Olomouc Faculty of Physical Culture, Olomouc, Olomouc Region, Czech Republic. FAU - Labisa Palmeira, Antonio AU - Labisa Palmeira A AUID- ORCID: 0000-0001-6508-0599 AD - Lusofona University of Humanities and Technologies Faculty of Physical Education and Sport, Lisbon, Lisbon, Portugal. AD - Lusofona University of Humanities and Technologies Research Center on Sports Physical Education Exercise and Health, Lisbon, Lisbon, Portugal. AD - University of Porto Research Centre for Training Innovation and Intervention in Sport, Porto, Porto District, Portugal. FAU - de Geus, Eco J C AU - de Geus EJC AD - Department of Biological Psychology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. LA - eng PT - Journal Article DEP - 20260902 PL - Belgium TA - Open Res Eur JT - Open research Europe JID - 9918230081006676 PMC - PMC13586601 OAB - This study looked at how parents, friends, and teachers might influence how active children aged 9 to 12 are in their daily lives. Physical activity is very important for children's growth and health. Doctors and health organizations recommend at least an hour of activity each day, yet most children around the world are not reaching this level. Being active helps children control their weight, strengthen their bones and muscles, and reduce the risk of health problems later in life. Researchers in Belgium, Czechia, and Ireland asked 181 families to take part. Both children and their parents wore activity trackers for eight days to measure how much moderate activity (like walking or playing outside) and vigorous activity (like running or sports) they did. Children also filled in questionnaires about how much support children felt from parents, friends, and teachers. The results showed that children were more active when their parents were active, especially for moderate activities. For example, if parents often walked or cycled, children were more likely to do the same. Vigorous activity, such as sports, showed weaker links to parents' behaviour and was only slightly connected to friends' encouragement. Teacher support was not found to make a difference in this study. These findings suggest that the best way to help children be more active is through family involvement, especially when parents take part in activities with their children. Friends' influence may become more important as children get older, but for this age group, parents are the strongest role models. This knowledge can help shape programs that aim to get children moving more often and more effectively. OABL- eng OTO - NOTNLM OT - Accelerometry; Physical activity intensity; Interpersonal Support; Parental modelling COIS- No competing interests were disclosed. EDAT- 2026/09/20 05:43 MHDA- 2026/09/20 05:44 PMCR- 2026/09/02 CRDT- 2026/09/20 03:45 PHST- 2026/07/31 00:00 [accepted] PHST- 2026/09/20 05:44 [medline] PHST- 2026/09/20 05:43 [pubmed] PHST- 2026/09/20 03:45 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - 10.12688/openreseurope.21538.4 [doi] PST - epublish SO - Open Res Eur. 2026 Sep 2;5:331. doi: 10.12688/openreseurope.21538.4. eCollection 2025. PMID- 42763398 OWN - NLM STAT- MEDLINE DCOM- 20260919 LR - 20260923 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Sep 11 TI - Evaluating the therapeutic efficacy of a modified ketogenic diet in children with autism spectrum disorder: a randomized controlled trial. LID - 10.1186/s12887-026-07708-3 [doi] LID - 893 AB - BACKGROUND: Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental disorder marked by persistent impairments in social communication and interaction, together with restricted and repetitive behavior or interests. Recent epidemiological data indicate that the prevalence of ASD has continued to increase worldwide. Current behavioral and pharmacological interventions remain limited in efficacy, particularly for associated comorbidities. In this context, metabolic interventions, especially the ketogenic diet (KD), have attracted growing interest as a potential therapeutic strategy. METHODS: A total of 62 young children with ASD admitted to Hefei Maternal and Child Health Hospital between January 2024 and January 2025 were prospectively enrolled and randomly assigned to a treatment group or a control group (31 per group). Both groups underwent hospital-based rehabilitation training on weekdays and home-based rehabilitation on weekends over a 2-month period. The treatment group additionally received a modified KD, comprising ketogenic nutritional powder and a structured dietary plan, with lunch provided at the hospital on training days while breakfast, dinner, weekend dietary implementation, and home monitoring were managed by caregivers. The control group followed a regular diet along with the same rehabilitation program. Changes in ASD-related symptoms were assessed using the Autism Behavior Checklist (ABC) and Childhood Autism Rating Scale (CARS). RESULTS: After two months of intervention, both groups showed significant reductions in ABC and CARS scores compared with baseline (P < 0.05). Between-group comparison of individual change scores showed larger reductions in the treatment group for both ABC (U = 324.000, P = 0.027) and CARS (U = 273.500, P = 0.003). CONCLUSIONS: In this cohort of young children with ASD, the modified ketogenic diet combined with rehabilitation training was associated with greater short-term reductions in ABC and CARS scores than rehabilitation alone. The intervention demonstrated acceptable short-term feasibility. TRIAL REGISTRATION: The Project was registered on China Clinical Trial Registry (ChiCTR) with the identifier ChiCTR2300075057 ,Registered 24 August 2023, https://www.chictr.org.cn/ . CI - (c) 2026. The Author(s). FAU - Liu, Le AU - Liu L AD - Child Neurological Rehabilitation Center, Hefei Maternal and Child Health Hospital, Hefei, China. FAU - Zhao, Qingsong AU - Zhao Q AD - Anhui Medical University Clinic Medical College, Hefei, China. FAU - Zhou, Jing AU - Zhou J AD - Child Neurological Rehabilitation Center, Hefei Maternal and Child Health Hospital, Hefei, China. FAU - Liu, Zhi AU - Liu Z AD - Shenzhen Zeneca Biotechnology Co., Ltd, Shenzhen, China. FAU - Wu, De AU - Wu D AD - Pediatric Neurorehabilitation Center, Pediatric Department, The First Affiliated Hospital of Anhui Medical University, Hefei, China. FAU - He, Kaiyin AU - He K AUID- ORCID: 0009-0000-2082-9762 AD - Child Neurological Rehabilitation Center, Hefei Maternal and Child Health Hospital, Hefei, China. hekaiyin@126.com. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260911 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Diet, Ketogenic/methods MH - Male MH - Female MH - *Autism Spectrum Disorder/diet therapy MH - Child, Preschool MH - Treatment Outcome MH - Prospective Studies PMC - PMC13589367 OTO - NOTNLM OT - Autism spectrum disorder OT - Childhood autism rating scale OT - Ketogenic diet OT - Treatment COIS- Declarations. Ethics approval and consent to participate: This study was conducted in strict compliance with the ethical principles outlined in the Declaration of Helsinki. Written informed consent was obtained from all participating children's legal guardians prior to their inclusion in the research. The study protocol received formal approval from the Institutional Review Board of Hefei Maternal and Child Health Hospital (Ethical Approval No.: YYLL2022-07-01-01) following rigorous ethical review procedures. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/20 05:43 MHDA- 2026/09/20 05:44 PMCR- 2026/09/11 CRDT- 2026/09/19 23:25 PHST- 2026/06/01 00:00 [received] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/09/20 05:44 [medline] PHST- 2026/09/20 05:43 [pubmed] PHST- 2026/09/19 23:25 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 10.1186/s12887-026-07708-3 [pii] AID - 7708 [pii] AID - 10.1186/s12887-026-07708-3 [doi] PST - epublish SO - BMC Pediatr. 2026 Sep 11;26(1):893. doi: 10.1186/s12887-026-07708-3. PMID- 42763327 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261019 IS - 1476-5624 (Electronic) IS - 1362-4393 (Print) IS - 1362-4393 (Linking) VI - 64 IP - 10 DP - 2026 Oct TI - Blood flow restricted exercise with and without transcutaneous spinal cord stimulation via telehealth in persons with tetraplegia. A protocol for randomized clinical trial. PG - 929-935 LID - 10.1038/s41393-026-01275-1 [doi] AB - STUDY DESIGN: A single site randomized clinical trial; Richmond, VA, USA. OBJECTIVE: To determine the effect of 16 weeks of home-based blood flow restriction-enhanced neuromuscular electrical stimulation (BES) and non-invasive transcutaneous spinal cord stimulation (TSS) with mass practiced (MP) training on cervical neuroplasticity and upper extremity function in individuals with tetraplegia. The program is supported by a telehealth-based approach designed to improve adherence. METHODS: Forty-four adults (18-70 years) with incomplete cervical SCI (AIS B-D; injury level C8 or above) will be randomized to TSS + BES + MP or sham TSS + BES + MP for 30 weeks. All participants, accompanied by a caregiver, will complete a 4-week education and training phase (2 weeks on-site, 2 weeks via telehealth), followed by 16 weeks of telehealth-supervised home training. Baseline assessments will occur before training (BL1) and after the education phase (Phase 1, BL2). Post-intervention (P1) testing will follow 16 weeks of home-based training (Phase 2), with an additional follow-up (Fw) after an 8-week washout period to evaluate any carry-over effects (Phase 3). The first 15 months will serve as a feasibility phase without randomization; data from these participants will be included within the TSS + BES + MP group. Randomization thereafter will be conducted using a computer-generated sequence. Home-based TSS application for upper extremity function is a feasible and safe strategy in persons with tetraplegia. The proposal is likely to ensure long-term compliance and adherence as well as to reduce the barriers associated with exercise interventions in persons with tetraplegia. SPONSORSHIP: National Institute on Disability, Independent Living, and Rehabilitation Research [NIDILRR]. GOV IDENTIFIER: NCT05423600. CI - (c) 2026. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. FAU - Gorgey, Ashraf S AU - Gorgey AS AUID- ORCID: 0000-0002-9157-6034 AD - Spinal Cord Injury and Disorders, Richmond VA Medical Center, Richmond, VA, USA. ashraf.gorgey@va.gov. AD - Virginia Commonwealth University, Department of Physical Medicine & Rehabilitation, Richmond, VA, USA. ashraf.gorgey@va.gov. FAU - Rehman, Muhammad U AU - Rehman MU AD - Spinal Cord Injury and Disorders, Richmond VA Medical Center, Richmond, VA, USA. AD - Virginia Commonwealth University, Department of Biomedical Engineering, Richmond, VA, USA. FAU - Wasim, Momal AU - Wasim M AD - Spinal Cord Injury and Disorders, Richmond VA Medical Center, Richmond, VA, USA. FAU - Khalil, Refka E AU - Khalil RE AD - Spinal Cord Injury and Disorders, Richmond VA Medical Center, Richmond, VA, USA. FAU - Brooks, Bret AU - Brooks B AD - Spinal Cord Injury and Disorders, Richmond VA Medical Center, Richmond, VA, USA. AD - Virginia Commonwealth University, Department of Physical Medicine & Rehabilitation, Richmond, VA, USA. FAU - Seel, Ronald AU - Seel R AD - Virginia Commonwealth University, Department of Physical Medicine & Rehabilitation, Richmond, VA, USA. AD - Virginia Commonwealth University; Center for Rehabilitation Science and Engineering (CERSE), Richmond, VA, USA. FAU - Chaggar, Rajbir AU - Chaggar R AUID- ORCID: 0000-0002-1685-4508 AD - Virginia Commonwealth University, Department of Physical Medicine & Rehabilitation, Richmond, VA, USA. FAU - Lavis, Timothy AU - Lavis T AD - Spinal Cord Injury and Disorders, Richmond VA Medical Center, Richmond, VA, USA. AD - Virginia Commonwealth University, Department of Physical Medicine & Rehabilitation, Richmond, VA, USA. LA - eng SI - ClinicalTrials.gov/NCT05423600 GR - 90SIMS0014/U.S. Department of Health & Human Services | ACL | National Institute on Disability, Independent Living, and Rehabilitation Research (NIDILRR)/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20260919 PL - England TA - Spinal Cord JT - Spinal cord JID - 9609749 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Exercise Therapy/methods MH - *Quadriplegia/rehabilitation/therapy/etiology/physiopathology MH - Regional Blood Flow/physiology MH - *Spinal Cord Injuries/complications/rehabilitation/therapy/physiopathology MH - *Spinal Cord Stimulation/methods MH - Telemedicine MH - *Transcutaneous Electric Nerve Stimulation/methods MH - Randomized Controlled Trials as Topic PMC - PMC13668687 COIS- Competing interests: The author declare no competing interests. EDAT- 2026/09/20 05:43 MHDA- 2026/10/15 07:17 PMCR- 2026/09/19 CRDT- 2026/09/19 23:15 PHST- 2025/11/11 00:00 [received] PHST- 2026/09/04 00:00 [accepted] PHST- 2026/08/24 00:00 [revised] PHST- 2026/10/15 07:17 [medline] PHST- 2026/09/20 05:43 [pubmed] PHST- 2026/09/19 23:15 [entrez] PHST- 2026/09/19 00:00 [pmc-release] AID - 10.1038/s41393-026-01275-1 [pii] AID - 1275 [pii] AID - 10.1038/s41393-026-01275-1 [doi] PST - ppublish SO - Spinal Cord. 2026 Oct;64(10):929-935. doi: 10.1038/s41393-026-01275-1. Epub 2026 Sep 19. PMID- 42763108 OWN - NLM STAT- MEDLINE DCOM- 20260919 LR - 20260925 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 10 IP - 1 DP - 2026 Sep 19 TI - Happiness Toolkit in a paediatric outpatient setting for children with social, emotional, behavioural and/or mental health difficulties: a prospective cohort study. LID - 10.1136/bmjpo-2026-005011 [doi] LID - e005011 AB - OBJECTIVE: To evaluate the feasibility, acceptability and clinical outcomes of the Happiness Toolkit (HTK), a structured, low-intensity, family-delivered intervention for children aged 0-16 years screening positive for social, emotional, behavioural and/or mental health difficulties (SEMHD) in a paediatric outpatient setting. DESIGN: Single-site prospective cohort study; validated age-specific baseline screening, parent-reported outcomes at 6 weeks and 6 months. SETTING: General paediatric outpatient department, secondary hospital, Ireland. PARTICIPANTS: Consecutive paediatric outpatient attendees screening positive for SEMHD on the Ages and Stages Questionnaires: Social-Emotional, Second Edition (under 6 years) or Screen for Child Anxiety Related Emotional Disorders questionnaire (6-16 years) were enrolled for intervention. INTERVENTIONS: The HTK comprises six evidence-based components practised for 5 minutes morning and evening, introduced during routine outpatient consultation. MAIN OUTCOME MEASURES: Primary: consent rate, positive screen rate and 6-week response rate (feasibility); parental willingness to recommend (acceptability). Secondary: parent-reported functional changes at 6 weeks and 6 months, component uptake and adverse events. RESULTS: 240 of 277 families approached across 16 outpatient clinics consented (86.6%); 94 children screened positive for SEMHD (39.2%) and received the HTK. At 6-week follow-up (n=46; 48.9% response rate), 95.2% of parents reported a positive or very positive experience, 73.9% noted improved mood in their child, 43.5% reduced screen time and 37.0% improved sleep patterns. 97.8% would recommend, with no adverse events. At 6-month follow-up (n=13; 13.8% response rate), 61.5% reported sustained child mood improvement and 92.3% would still recommend. CONCLUSIONS: This study demonstrates strong feasibility and high parental acceptability for the HTK when embedded in routine paediatric outpatient care. Parent-reported improvements at 6 weeks and no adverse events at both time points support progression to a controlled evaluation. In Ireland, 4462 children await Child and Adolescent Mental Health Services and over 28 000 await primary care psychology; the HTK represents a promising, pragmatic early and bridging support for emerging SEMHD. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Eustace, Kate AU - Eustace K AUID- ORCID: 0000-0002-1537-9805 AD - Paediatrics, Midland Regional Hospital Mullingar, Mullingar, Ireland kateeustace1@gmail.com. FAU - McCrory, Sarah Alexandra AU - McCrory SA AUID- ORCID: 0009-0004-8525-4567 AD - Paediatrics, Midland Regional Hospital Mullingar, Mullingar, Ireland. FAU - Sharif, Farhana AU - Sharif F AUID- ORCID: 0009-0002-0051-8953 AD - Paediatrics, Midland Regional Hospital Mullingar, Mullingar, Ireland. AD - Paediatrics, RCSI, Dublin, Ireland. LA - eng PT - Journal Article DEP - 20260919 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Prospective Studies MH - Child, Preschool MH - Adolescent MH - Feasibility Studies MH - *Mental Disorders/therapy/diagnosis MH - Infant MH - Surveys and Questionnaires MH - Parents/psychology MH - Ireland MH - *Child Behavior Disorders/therapy/diagnosis MH - *Happiness MH - Infant, Newborn PMC - PMC13599945 OTO - NOTNLM OT - Adolescent Health OT - Child Health OT - Child Psychiatry OT - Psychology OT - Qualitative research EDAT- 2026/09/19 23:52 MHDA- 2026/09/19 23:53 PMCR- 2026/09/19 CRDT- 2026/09/19 20:42 PHST- 2026/05/27 00:00 [received] PHST- 2026/08/28 00:00 [accepted] PHST- 2026/09/19 23:53 [medline] PHST- 2026/09/19 23:52 [pubmed] PHST- 2026/09/19 20:42 [entrez] PHST- 2026/09/19 00:00 [pmc-release] AID - 10.1136/bmjpo-2026-005011 [pii] AID - bmjpo-2026-005011 [pii] AID - 10.1136/bmjpo-2026-005011 [doi] PST - epublish SO - BMJ Paediatr Open. 2026 Sep 19;10(1):e005011. doi: 10.1136/bmjpo-2026-005011. PMID- 42762125 OWN - NLM STAT- Publisher LR - 20260919 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 Sep 19 TI - Feasibility of millet-based gluten free and casein free diet in children with autism spectrum disorders: A 12-week pilot study in India. PG - 2601060261489302 LID - 10.1177/02601060261489302 [doi] AB - BackgroundAutism spectrum disorder (ASD) is often associated with selective eating, nutritional deficiencies, and gastrointestinal (GI) disturbances. Gluten-free, casein-free (GFCF) diets are popular but inconsistently supported by evidence. Millets, naturally gluten and casein-free, are nutrient-dense traditional grains that may offer a culturally relevant alternative.AimTo assess the feasibility, acceptability, adherence, and nutritional impact of a millet-based GFCF dietary intervention in children with ASD.MethodsA 12-week single-arm pilot study enrolled children aged 4 to 6 years with confirmed ASD. A millet flour blend (foxtail, little, pearl millet) was developed into three recipes: Foxtail Millet Upma, Little Millet Biscuits, and Pearl Millet Nachos. Pre and postintervention dietary intake was measured using 3-day recalls. Sensory acceptability was rated on a nine-point hedonic scale; adherence was tracked through caregiver logs; and structured interviews explored feasibility.SummaryAll millet-based recipes were well accepted, with Foxtail Millet Upma receiving the highest acceptability scores. Significant improvements were observed in cereal and pulse intake, along with a reduction in fat consumption. Caregivers reported improvements in GI comfort (70%), sleep quality (60%), and reductions in hyperactivity (55%). Adherence to the dietary intervention was high (80%), although challenges related to ingredient availability and preparation time were reported. Millet-based GFCF diets are feasible, acceptable, and nutritionally balanced at the food-group level in children with ASD. Findings highlight their potential as culturally appropriate dietary interventions, warranting larger controlled studies to evaluate long-term outcomes. FAU - Dahake, Urmila AU - Dahake U AUID- ORCID: 0000-0001-6822-8317 AD - Department of Pediatrics, All India Institute of Medical Sciences, Nagpur, India. RINGGOLD: 534693 FAU - Deotale, Shweta AU - Deotale S AUID- ORCID: 0000-0003-4409-278X AD - Department of Chemical Engineering, Visvesvaraya National Institute of Technology, Nagpur, India. RINGGOLD: 29583 FAU - Mandavgane, Sachin AU - Mandavgane S AUID- ORCID: 0000-0002-1436-8987 AD - Department of Chemical Engineering, Visvesvaraya National Institute of Technology, Nagpur, India. RINGGOLD: 29583 FAU - Sharma, Shakti AU - Sharma S AD - Department of Food Science and Nutrition, Sadabai Raisoni Women's College, Nagpur, India. FAU - Bang, Akash AU - Bang A AUID- ORCID: 0000-0003-2035-1193 AD - Department of Pediatrics, All India Institute of Medical Sciences, Nagpur, India. RINGGOLD: 534693 FAU - Solanki, Ranjan AU - Solanki R AD - Department of Community Medicine, All India Institute of Medical Sciences, Nagpur, India. RINGGOLD: 534693 FAU - Kumar, Anupama AU - Kumar A AUID- ORCID: 0000-0002-9051-1482 AD - Department of Chemical Engineering, Visvesvaraya National Institute of Technology, Nagpur, India. RINGGOLD: 29583 LA - eng PT - Journal Article DEP - 20260919 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - Autism spectrum disorder OT - India OT - casein-free diet OT - food selectivity OT - gluten-free diet OT - gut-brain axis OT - millets OT - nutritional intervention OT - pediatric nutrition EDAT- 2026/09/19 23:52 MHDA- 2026/09/19 23:52 CRDT- 2026/09/19 07:52 PHST- 2026/09/19 23:52 [medline] PHST- 2026/09/19 23:52 [pubmed] PHST- 2026/09/19 07:52 [entrez] AID - 10.1177/02601060261489302 [doi] PST - aheadofprint SO - Nutr Health. 2026 Sep 19:2601060261489302. doi: 10.1177/02601060261489302. PMID- 42761920 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260919 LR - 20260923 IS - 1178-7074 (Print) IS - 1178-7074 (Electronic) IS - 1178-7074 (Linking) VI - 19 DP - 2026 TI - Trajectories of Gestational Weight Gain During Early and Mid-Pregnancy and Their Association with Hypertensive Disorders of Pregnancy. PG - 634468 LID - 10.2147/IJGM.S634468 [doi] LID - 634468 AB - OBJECTIVE: To examine the association between trajectories of gestational weight gain (GWG) during early and mid-pregnancy and hypertensive disorders of pregnancy (HDP). A trajectory approach was used because total GWG or a single measurement cannot represent the timing and pattern of weight change. METHODS: This retrospective cohort included 11,278 women who attended the nutrition clinic and delivered at Fujian Provincial Maternity and Child Health Hospital, Fuzhou, China, between March 2014 and May 2018. Interval-specific GWG through 28 weeks was characterized using latent class growth modeling. Logistic regression estimated associations with HDP; the fully adjusted model included maternal age, pre-pregnancy body mass index, parity, platelet count, lactate dehydrogenase, and alanine aminotransferase. RESULTS: The current analysis used four reported GWG patterns: stable-low (Group 1; n=9,314, 82.6%), early-slow/mid-fast (Group 2; n=70, 0.6%), early-fast/mid-slow (Group 3; n=301, 2.7%), and moderate-growth (Group 4; n=1,593, 14.1%). Compared with Group 1, the fully adjusted odds of HDP were higher in Group 3 (odds ratio [OR]=2.285, 95% confidence interval [CI] 1.370-3.613; P=0.001) and Group 4 (OR=1.356, 95% CI 1.037-1.752; P=0.023), but not Group 2 (OR=1.084, 95% CI 0.176-3.528; P=0.911). CONCLUSION: In this hospital-based cohort, early- and mid-pregnancy GWG patterns were associated with HDP. The estimates for the smallest groups were imprecise, and the observational design does not establish causality or predictive utility. Studies with prospectively recorded HDP diagnosis timing and external validation are required before clinical use. CI - (c) 2026 Li et al. FAU - Li, Wenwen AU - Li W AD - Department of Gynecology II, Fujian Provincial Maternity and Children's Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. FAU - Kang, Youhong AU - Kang Y AUID- ORCID: 0009-0001-7528-7152 AD - Obstetrics Department, Quanzhou Maternal and Child Health Hospital (Quanzhou Children's Hospital), Quanzhou, Fujian, People's Republic of China. FAU - Zhang, Huale AU - Zhang H AD - Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. FAU - Tan, Wenxin AU - Tan W AD - Department of Obstetrics, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. FAU - Li, Feng AU - Li F AD - Department of Gynecology II, Fujian Provincial Maternity and Children's Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. FAU - Wu, Kunhai AU - Wu K AD - Blood Transfusion Department, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. AD - Blood Transfusion Department, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. FAU - Fang, Zhuanji AU - Fang Z AD - Department of Obstetrics and Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People's Republic of China. LA - eng PT - Journal Article DEP - 20260914 PL - New Zealand TA - Int J Gen Med JT - International journal of general medicine JID - 101515487 PMC - PMC13588108 OTO - NOTNLM OT - gestational weight gain OT - hypertensive disorders of pregnancy OT - latent class growth model OT - longitudinal trajectory OT - pregnancy COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/19 23:52 MHDA- 2026/09/19 23:53 PMCR- 2026/09/14 CRDT- 2026/09/19 06:25 PHST- 2026/07/08 00:00 [received] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/09/19 23:53 [medline] PHST- 2026/09/19 23:52 [pubmed] PHST- 2026/09/19 06:25 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - 634468 [pii] AID - 10.2147/IJGM.S634468 [doi] PST - epublish SO - Int J Gen Med. 2026 Sep 14;19:634468. doi: 10.2147/IJGM.S634468. eCollection 2026. PMID- 42761388 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260919 LR - 20260921 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 9 DP - 2026 Sep TI - Lifestyle Behaviors and Their Socio-Demographic Correlates Among University-Going Adolescents in Rawalpindi, Pakistan: A Cross-Sectional Study. PG - e73240 LID - 10.1002/hsr2.73240 [doi] LID - e73240 AB - OBJECTIVE: Adolescence is a critical period where lifestyle habits, including diet, physical exercise, sleep, and substance abuse, may have a significant influence on future health. The objective of this study was to determine adolescents' lifestyle behaviors and how they relate to socio-demographic characteristics. METHODS: The study included university-going older adolescents in Rawalpindi, Pakistan and employed a cross-sectional study design. Participants completed a validated questionnaire assessing lifestyle behaviors and their socio-demographic correlates, along with anthropometric measurements for BMI categorization. Chi-square test and multivariate logistic regression were used for analysis. RESULTS: The present study included 215 university-going older adolescents (mean age: 18.69 SD = 0.46 years); the majority (75.8%) were female participants, and 70.2% were urban inhabitants. The majority had a healthy BMI (68.8%) and ate three meals each day (90.7%), but less than 12% were physically active. Over a quarter reported not getting enough sleep. 28.4% of participants reported depressed symptoms; just 10.2% addressed their problems with a specialist. 9.8% used drugs (smoking), 20.9% vaped, and 25.6% began using before the age of 12. There were significant (p < 0.05) associations between lifestyle behaviors and socio-demographic characteristics such as age, BMI, and family type. Regression analysis showed BMI, residence, and parental education as key predictors of adolescent lifestyle. CONCLUSION: The findings revealed significant gaps in healthy lifestyle behaviors university-going older adolescents in Rawalpindi. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Rao, Meesha AU - Rao M AD - Department of Research and Development Armed Forces Institute of Cardiology/National Institute of Heart Diseases Rawalpindi Pakistan. FAU - Mahmood, Humaira AU - Mahmood H AUID- ORCID: 0000-0003-2341-6431 AD - School of Public Health Health Services Academy Islamabad Pakistan. FAU - Ahmad, Abdul Momin Rizwan AU - Ahmad AMR AUID- ORCID: 0000-0003-3499-902X AD - Department of Human Nutrition and Dietetics, NUST School of Health Sciences National University of Sciences and Technology (NUST) Islamabad Pakistan. AD - Department of Health Sciences University of York York UK. FAU - Zafar, Saira AU - Zafar S AUID- ORCID: 0009-0007-1850-5081 AD - School of Public Health Health Services Academy Islamabad Pakistan. FAU - Khalid, Hasnain AU - Khalid H AD - School of Management Xuzhou Medical University Xuzhou China. FAU - Siddiqui, Manaar Adil AU - Siddiqui MA AD - Department of Public Health, Armed Forces Postgraduate Medical Institute (AFPGMI) National University of Medical Sciences (NUMS) Rawalpindi Pakistan. FAU - Azad, Naseem AU - Azad N AD - Department of Public Health, Armed Forces Postgraduate Medical Institute (AFPGMI) National University of Medical Sciences (NUMS) Rawalpindi Pakistan. FAU - Abbasi, Attiya Najeeb AU - Abbasi AN AD - Department of Public Health, Armed Forces Postgraduate Medical Institute (AFPGMI) National University of Medical Sciences (NUMS) Rawalpindi Pakistan. FAU - Mohammadi, Nilab AU - Mohammadi N AUID- ORCID: 0009-0003-6376-0007 AD - Department of Curative Medicine Ghalib University Herat Afghanistan. LA - eng PT - Journal Article DEP - 20260917 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13586443 OTO - NOTNLM OT - adolescents OT - lifestyle behaviors OT - physical activity OT - socio-demographic correlates OT - university students COIS- The authors declare that they do not have any conflict of interest. EDAT- 2026/09/19 23:52 MHDA- 2026/09/19 23:53 PMCR- 2026/09/17 CRDT- 2026/09/19 05:36 PHST- 2026/07/25 00:00 [received] PHST- 2026/08/27 00:00 [revised] PHST- 2026/09/05 00:00 [accepted] PHST- 2026/09/19 23:53 [medline] PHST- 2026/09/19 23:52 [pubmed] PHST- 2026/09/19 05:36 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - HSR273240 [pii] AID - 10.1002/hsr2.73240 [doi] PST - epublish SO - Health Sci Rep. 2026 Sep 17;9(9):e73240. doi: 10.1002/hsr2.73240. eCollection 2026 Sep. PMID- 42761262 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260919 LR - 20260921 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - A comprehensive narrative review of scoliosis in children and adolescents: epidemiology, screening strategies, therapeutic interventions, and biomechanical research. PG - 1866246 LID - 10.3389/fped.2026.1866246 [doi] LID - 1866246 AB - Scoliosis in children and adolescents, particularly adolescent idiopathic scoliosis (AIS), is a complex three-dimensional spinal deformity with a well-defined global prevalence and a considerable disease burden. This narrative review synthesizes the latest advances in the field, encompassing epidemiology, screening strategies, conservative treatment (bracing and physiotherapeutic scoliosis-specific exercises), biomechanical research, and artificial intelligence applications. A recent global meta-analysis indicates that the overall prevalence of scoliosis in children and adolescents is approximately 1.65%, with a consistent female predominance observed across most studies (global pooled OR = 2.16, 95% CI: 2.01-2.33), although the magnitude of this sex disparity varies by region, and prevalence increasing with age. However, the included studies are geographically unbalanced, with limited data from low-latitude regions, which may bias the global prevalence estimate. School-based screening remains the cornerstone of early detection, but screening policies vary significantly across countries. The development of novel home-based screening tools offers a new approach to overcome the limitations of school screening, yet their widespread adoption is constrained by economic factors and parental awareness. Multiple randomized controlled trials and meta-analyses have confirmed the efficacy of bracing and physiotherapeutic scoliosis-specific exercises, but no unified clinical guidelines exist for selecting the optimal treatment strategy. Furthermore, long-term longitudinal evidence on the intrinsic link between treatment approaches and patients' mental health is still lacking. In addition, biomechanical techniques such as finite element analysis provide new perspectives for elucidating the mechanical properties of scoliosis and optimizing treatment strategies, but most models are constructed under idealized conditions, differing from the physiological state, and their clinical translational value awaits further validation. This review integrates core evidence from the field, aiming to provide a reference for clinical practice and future research directions. CI - (c) 2026 Chuan, Feina, Aigong and Shaoling. FAU - Chuan, Sun AU - Chuan S AD - Binzhou Medical University, Binzhou, Shandong, China. AD - Zhaoyuan Hospital of Traditional Chinese Medicine, Yantai, Shandong, China. FAU - Feina, Cong AU - Feina C AD - Zhaoyuan Hospital of Traditional Chinese Medicine, Yantai, Shandong, China. FAU - Aigong, Qiu AU - Aigong Q AD - Zhaoyuan Hospital of Traditional Chinese Medicine, Yantai, Shandong, China. FAU - Shaoling, Xu AU - Shaoling X AD - Zhaoyuan Hospital of Traditional Chinese Medicine, Yantai, Shandong, China. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260904 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13585927 OTO - NOTNLM OT - adolescent idiopathic scoliosis OT - artificial intelligence OT - biomechanics OT - bracing OT - epidemiology OT - exercise therapy OT - mental health OT - screening strategies COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/19 23:52 MHDA- 2026/09/19 23:53 PMCR- 2026/09/04 CRDT- 2026/09/19 05:22 PHST- 2026/04/27 00:00 [received] PHST- 2026/08/06 00:00 [revised] PHST- 2026/08/13 00:00 [accepted] PHST- 2026/09/19 23:53 [medline] PHST- 2026/09/19 23:52 [pubmed] PHST- 2026/09/19 05:22 [entrez] PHST- 2026/09/04 00:00 [pmc-release] AID - 10.3389/fped.2026.1866246 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 4;14:1866246. doi: 10.3389/fped.2026.1866246. eCollection 2026. PMID- 42760922 OWN - NLM STAT- MEDLINE DCOM- 20260919 LR - 20260920 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Pre-Ramadan time-below-range stratifies the simulated pump basal-rate dose-response during Ramadan fasting: a five-policy paired virtual-patient study. PG - 1922149 LID - 10.3389/fendo.2026.1922149 [doi] LID - 1922149 AB - BACKGROUND: Pump basal-rate reduction during Ramadan may prevent hypoglycemia but can increase hyperglycemia. Its dose-response relation and phenotype-dependent trade-off remain uncertain. METHODS: Thirty UVA/Padova virtual patients (10 children, 10 adolescents, 10 adults) underwent paired 30-day Ramadan conditions delivering 100%, 90%, 80%, 70%, or 60% of the pump steady-state basal rate. The primary complete-case analysis included 29 virtual patients. Outcomes were time in range (TIR), time below range (TBR), time above range (TAR, including TAR > 250 and TAR > 300), and rescue corrections. Paired permutation tests and bootstrap intervals quantified effects. Robustness and revision analyses used three sensor seeds, three seeded meal/timing scenarios with a held-out evaluation, a reactive-correction sensitivity analysis, a time-of-day decomposition, terminal-event reporting, and a negative-control (sham) test of the pre-Ramadan marker. RESULTS: Mean TIR was 81.7%, 79.9%, 73.9%, 65.3%, and 56.0% at 100%, 90%, 80%, 70%, and 60%, respectively (P <0.001). Compared with 100%, 90% basal reduced TBR by 1.6 percentage points (95% CI -2.1 to -1.2) while changing TIR by -1.8 points (95% CI -3.7 to -0.3; Holm-adjusted P = 0.031). Severe hyperglycemia rose steeply with deeper reduction (TAR>250: 2.9% at 100% to 14.8% at 60%). Enabling realistic reactive corrections raised TIR at the deepest policies but preserved the same policy ordering. Pre-Ramadan TBR stratified the TIR response across reduced policies (omnibus patient-blocked permutation P = 0.023), with the strongest gradients at 70% and 60% basal; a negative-control analysis showed this signal was not specific to TBR but reflected a broader baseline-glycemia pattern. In a held-out scenario, a revised safety-first selection rule improved hypoglycemia-target attainment (39% to 79%) and reduced TBR by 2.9 points but incurred a 5.2-point TIR cost, demonstrating that prioritizing fasting safety involves a glycemic trade-off. CONCLUSION: Ramadan pump basal-rate reduction should be treated not as a uniform percentage change but as a phenotype- and context-dependent trade-off. Among the reduced policies, 90% basal produced the smallest TIR loss while lowering hypoglycemia; pre-Ramadan TBR was an exploratory candidate stratifier; and meal-size associations differed by policy. These mechanistic findings apply to simulated pump basal-rate modulation and require prospective, CGM-anchored validation before any clinical use. CI - Copyright (c) 2026 Banjar. FAU - Banjar, Ameen AU - Banjar A AD - Department of Information Systems and Technology, College of Computer Science and Engineering, University of Jeddah, Jeddah, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260904 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Blood Glucose) RN - 0 (Insulin) RN - 0 (Hypoglycemic Agents) SB - IM MH - Humans MH - Adolescent MH - Male MH - *Islam MH - Female MH - Blood Glucose/analysis/metabolism MH - *Fasting MH - Child MH - *Insulin Infusion Systems MH - Adult MH - *Insulin/administration & dosage MH - *Hypoglycemia/prevention & control MH - Intermittent Fasting MH - *Diabetes Mellitus, Type 1/drug therapy/blood MH - Hypoglycemic Agents/administration & dosage MH - Hyperglycemia/prevention & control MH - Young Adult PMC - PMC13585517 OTO - NOTNLM OT - basal insulin OT - continuous glucose monitoring OT - dose response OT - precision dosing OT - ramadan OT - treatment heterogeneity OT - type 1 diabetes OT - virtual patients COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/19 05:39 MHDA- 2026/09/19 05:40 PMCR- 2026/09/04 CRDT- 2026/09/19 04:28 PHST- 2026/06/28 00:00 [received] PHST- 2026/07/23 00:00 [revised] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/09/19 05:40 [medline] PHST- 2026/09/19 05:39 [pubmed] PHST- 2026/09/19 04:28 [entrez] PHST- 2026/09/04 00:00 [pmc-release] AID - 10.3389/fendo.2026.1922149 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Sep 4;17:1922149. doi: 10.3389/fendo.2026.1922149. eCollection 2026. PMID- 42760401 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20261013 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 10 DP - 2026 Sep 19 TI - Risk factors for acute kidney injury after pediatric liver transplantation: a systematic review and meta-analysis. LID - 764 [pii] LID - 10.1007/s00431-026-07419-y [doi] AB - This study sought to systematically evaluate the incidence rates and risk factors of acute kidney injury (AKI) following pediatric liver transplantation (PLT), providing robust evidence for early identification of high-risk pediatric patients and development of perioperative intervention strategies. PubMed, Cochrane Library, Web of Science, and Embase were searched from their inception to September 2025 for observational studies on risk factors for AKI following PLT. Literature screening, data extraction, and quality assessment were independently completed by two researchers. The Newcastle-Ottawa Scale (NOS) was used to evaluate the quality of included studies. Meta-analysis was conducted using StataMP 17.0. In total, 17 retrospective cohort studies were included, involving 2986 pediatric liver transplant recipients. The pooled incidence rate of AKI following PLT was 30.7% [95% CI (25.0%, 36.3%)]. Several perioperative and patient-related factors may be associated with postoperative AKI. However, many of these factors were evaluated in only a small number of studies, and the corresponding pooled estimates should therefore be interpreted cautiously. Sensitivity analyses showed that the overall pooled estimates were robust, and the impact of publication bias was minimal. Conclusion: The incidence rate of AKI following PLT is relatively high. Furthermore, its occurrence is influenced by multiple factors, including preoperative hepatic impairment, coagulation abnormalities, inadequate nutrition and oxygen delivery, intraoperative blood loss, transfusion burden, and ischemia-reperfusion injury, and the requirement for continuous postoperative organ support. Clinically, comprehensive risk assessment and management across the entire perioperative period should be strengthened. Moreover, early identification of high-risk patients and implementation of targeted interventions should be prioritized to reduce the risk of AKI and improve clinical outcomes. However, the evidence for many individual factors was derived from a limited number of studies and should be interpreted cautiously. Further large-scale prospective studies are needed to validate these associations and guide risk-stratified perioperative management. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Cai, Wenjun AU - Cai W AD - School of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, 330004, Jiangxi, China. FAU - Wang, Danting AU - Wang D AD - School of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, 330004, Jiangxi, China. FAU - Zhu, Lu AU - Zhu L AD - The Second Affiliated Hospital, Jiangxi University of Chinese Medicine, Nanchang, 330004, Jiangxi, China. FAU - Liu, Xiujuan AU - Liu X AD - School of Clinical Medicine, Jiangxi University of Chinese Medicine, Nanchang, 330004, Jiangxi, China. liuxinfanjian@126.com. AD - Department of Nephrology, The 908th, Hospital of Chinese People's Liberation Army Joint Logistic Support Force, Nanchang, 330002, Jiangxi, China. liuxinfanjian@126.com. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260919 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Acute Kidney Injury/epidemiology/etiology MH - *Liver Transplantation/adverse effects MH - Risk Factors MH - Child MH - *Postoperative Complications/epidemiology/etiology MH - Incidence OTO - NOTNLM OT - Acute kidney injury OT - Children OT - Liver transplantation OT - Meta-analysis OT - Risk factors COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Clinical trial number: Not applicable. Declaration of artificial intelligence: The authors declare that no artificial intelligence was used at the time of writing the paper. EDAT- 2026/09/19 05:39 MHDA- 2026/09/19 05:40 CRDT- 2026/09/18 23:33 PHST- 2026/07/15 00:00 [received] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/19 05:40 [medline] PHST- 2026/09/19 05:39 [pubmed] PHST- 2026/09/18 23:33 [entrez] AID - 10.1007/s00431-026-07419-y [pii] AID - 10.1007/s00431-026-07419-y [doi] PST - epublish SO - Eur J Pediatr. 2026 Sep 19;185(10):764. doi: 10.1007/s00431-026-07419-y. PMID- 42759561 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261013 IS - 1361-6579 (Electronic) IS - 0967-3334 (Linking) VI - 47 IP - 10 DP - 2026 Oct 13 TI - Improving sleep monitoring in athletes: a comparative evaluation of four automated sleep scoring algorithms on 204 polysomnography recordings. LID - 10.1088/1361-6579/aea9ea [doi] AB - Objective.Automated sleep scoring offers the potential for fast, precise, and cost-effective analysis. This study evaluated the accuracy, robustness, and clinical agreement of four algorithms against manual polysomnography (PSG) in athletes, and assessed how signal degradation and individual physiological traits affect automated scoring in ambulatory settings.Approach.Data from 75 healthy athletes (91.1% male, mean age 26.3 +/- 5.4 years, range [18-41], 204 PSG recordings) were retrospectively collected from studies conducted in our laboratory. Manual scoring was compared to four automated sleep staging algorithms: Luna, U-Sleep, Yet Another Spindle Algorithm (YASA), and Greifswald Sleep Stage Classifier (GSSC). Performance was evaluated on accuracy (per stage, macro and weightedF1), sensitivity (confusion matrices), robustness (signal quality:R(2); individual differences: beta coefficients) and clinical relevance (prediction of total sleep time (TST), sleep onset latency (SOL), wake after sleep onset (WASO) and sleep efficiency (SE)).Main results.All algorithms demonstrated strong agreement with manual scoring, with macroF1 scores of 0.76 (GSSC), 0.71 (U-Sleep), 0.70 (YASA), and 0.69 (Luna). GSSC was the most accurate and robust across sport, physiological, behavioral, and anthropometric variables. It showed minimal bias and narrow limits of agreement for TST, WASO and SE. GSSC was also the most resilient to signal degradation (marginalR(2)= 0.05), compared to YASA and Luna (0.06) and U-Sleep (0.24).Significance.Automated sleep staging algorithms demonstrated accuracy comparable to typical inter-rater agreement, supporting broader use in athletes. These algorithms could make PSG more accessible for both monitoring and research, providing deeper insights into sleep and its influence on athletic performance. CI - Creative Commons Attribution license. FAU - Crosbie, Flynn AU - Crosbie F AUID- ORCID: 0009-0006-1635-194X AD - Universite Paris Cite, VIFASOM (Vigilance fatigue Sommeil et Sante Publique), Paris, France. AD - INSEP (Institut National du Sport, de l'Expertise et de la Performance), Paris, France. FAU - Hanif, Umaer AU - Hanif U AUID- ORCID: 0000-0001-8288-5532 AD - Universite Paris Cite, VIFASOM (Vigilance fatigue Sommeil et Sante Publique), Paris, France. FAU - Aloulou, Anis AU - Aloulou A AUID- ORCID: 0000-0002-4124-3864 AD - Universite Paris Cite, VIFASOM (Vigilance fatigue Sommeil et Sante Publique), Paris, France. AD - APHP, Hotel-Dieu, Centre du Sommeil et de la Vigilance, Paris, France. FAU - Chauvineau, Maxime AU - Chauvineau M AUID- ORCID: 0000-0002-0690-8074 AD - Universite Paris Cite, VIFASOM (Vigilance fatigue Sommeil et Sante Publique), Paris, France. AD - APHP, Hotel-Dieu, Centre du Sommeil et de la Vigilance, Paris, France. FAU - Chennaoui, Mounir AU - Chennaoui M AUID- ORCID: 0000-0002-4409-813X AD - Universite Paris Cite, VIFASOM (Vigilance fatigue Sommeil et Sante Publique), Paris, France. AD - IRBA (Institut de Recherche biomedicale des armees), Bretigny, France. FAU - Nedelec, Mathieu AU - Nedelec M AUID- ORCID: 0000-0001-8095-9163 AD - INSEP (Institut National du Sport, de l'Expertise et de la Performance), Paris, France. FAU - Leger, Damien AU - Leger D AUID- ORCID: 0000-0003-1168-480X AD - Universite Paris Cite, VIFASOM (Vigilance fatigue Sommeil et Sante Publique), Paris, France. AD - APHP, Hotel-Dieu, Centre du Sommeil et de la Vigilance, Paris, France. LA - eng PT - Comparative Study PT - Evaluation Study PT - Journal Article DEP - 20261013 PL - England TA - Physiol Meas JT - Physiological measurement JID - 9306921 SB - IM MH - Humans MH - *Polysomnography/methods MH - *Algorithms MH - Male MH - Adult MH - Female MH - Automation MH - Adolescent MH - *Athletes MH - *Sleep/physiology MH - Young Adult MH - Sleep Stages MH - Sleep Duration MH - Signal Processing, Computer-Assisted OTO - NOTNLM OT - EEG OT - artificial intelligence OT - athletes OT - automated scoring OT - polysomnography OT - sleep staging EDAT- 2026/09/18 23:36 MHDA- 2026/10/13 17:37 CRDT- 2026/09/18 19:08 PHST- 2026/05/09 00:00 [received] PHST- 2026/09/18 00:00 [accepted] PHST- 2026/10/13 17:37 [medline] PHST- 2026/09/18 23:36 [pubmed] PHST- 2026/09/18 19:08 [entrez] AID - 10.1088/1361-6579/aea9ea [doi] PST - epublish SO - Physiol Meas. 2026 Oct 13;47(10). doi: 10.1088/1361-6579/aea9ea. PMID- 42758477 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20260922 IS - 1460-2210 (Electronic) IS - 0141-5387 (Print) IS - 0141-5387 (Linking) VI - 48 IP - 5 DP - 2026 Aug 6 TI - Metabolomic analysis of gingival crevicular fluid for dental age and skeletal maturity assessment in growing individuals. LID - 10.1093/ejo/cjag064 [doi] LID - cjag064 AB - OBJECTIVES: The aim of this study was to examine the metabolic profile of growing patients for potential identification of biomarkers related to dental skeletal development. MATERIALS AND METHODS: Gingival crevicular fluid samples from 54 young patients were collected and further analyzed by an untargeted gas chromatography-mass spectrometry method. For the estimation of dental development, the Demirjian method was used, and for the skeletal maturation level, the cervical vertebrae maturation method was applied. Multivariate and univariate analyses were performed to examine possible metabolomic variations according to the chronological, dental, and skeletal age. Group differences were evaluated using Kruskal-Wallis tests, with Bonferroni correction applied to account for multiple comparisons. Spearman's rho correlation coefficient was used to examine variable correlations. Metabolite expression variations were visualized using boxplots. RESULTS: In total, 63 compounds were retrieved with metabolomic analysis. The results showed that cadaverine and L-valine uniquely displayed robust dental age-related variation, demonstrating significant elevations during tooth development and decrease in the late stages of the dentition. Malonic acid and nonanoic acid decrease with advanced dental age. Regarding bone growth, cadaverine, L-serine, and L-homoserine have been identified as strong indicators of skeletal maturation. CONCLUSIONS: Several distinct metabolites showed coherent associations with skeletal and dental maturation. Additional studies employing complementary analytical methods and broader metabolome profiling are necessary to validate their association with tooth and bone growth pathways. CLINICAL SIGNIFICANCE: The adjunct use of metabolomics in dentistry and orthodontics may lead to more precise diagnosis and personalized healthcare. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the European Orthodontic Society. FAU - Eirini, Tsagkari AU - Eirini T AD - Department of Orthodontics, Faculty of Dentistry, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. FAU - Eleftherios, Panteris AU - Eleftherios P AD - Biomic_AUTh, CIRI-AUTH Center for Interdisciplinary Research and Innovation, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. FAU - Moschos, Papadopoulos A AU - Moschos PA AD - Department of Orthodontics, Faculty of Dentistry, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. FAU - Athina, Chatzigianni AU - Athina C AUID- ORCID: 0000-0001-7114-689X AD - Department of Orthodontics, Faculty of Dentistry, School of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. LA - eng GR - Greece/ GR - MIS 5047928/European Union (European Social Fund-ESF)/ PT - Journal Article PL - England TA - Eur J Orthod JT - European journal of orthodontics JID - 7909010 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Gingival Crevicular Fluid/chemistry/metabolism MH - *Age Determination by Teeth/methods MH - *Metabolomics/methods MH - Gas Chromatography-Mass Spectrometry/methods MH - Female MH - Child MH - Biomarkers/analysis/metabolism MH - Male MH - *Age Determination by Skeleton/methods MH - Cervical Vertebrae/growth & development MH - Adolescent MH - *Odontogenesis/physiology MH - *Bone Development/physiology PMC - PMC13587827 OTO - NOTNLM OT - biomarkers OT - dentistry OT - metabolomics OT - orthodontics OT - skeletal growth OT - tooth development COIS- Conflicts of interest: The authors declare that there is no conflict of interest. EDAT- 2026/09/18 17:36 MHDA- 2026/09/18 17:37 PMCR- 2026/09/18 CRDT- 2026/09/18 11:26 PHST- 2026/09/18 17:37 [medline] PHST- 2026/09/18 17:36 [pubmed] PHST- 2026/09/18 11:26 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 8817247 [pii] AID - cjag064 [pii] AID - 10.1093/ejo/cjag064 [doi] PST - ppublish SO - Eur J Orthod. 2026 Aug 6;48(5):cjag064. doi: 10.1093/ejo/cjag064. PMID- 42757670 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20261001 IS - 1536-7290 (Electronic) IS - 1746-1391 (Print) IS - 1536-7290 (Linking) VI - 26 IP - 10 DP - 2026 Oct TI - Measurement Agreement and Reliability of the 6-m Gait Speed Test in Adult Population: The ADULT-FIT Project. PG - e70207 LID - 10.1002/ejsc.70207 [doi] LID - e70207 AB - We aimed to examine: (i) measurement agreement between photoelectric cell system and manual stopwatch timing; (ii) inter-rater agreement between trained and untrained raters using manual stopwatch timing; and (iii) reliability of the 6-m gait speed test to assess motor fitness in adults, according to sex, age, and physical activity levels. 410 healthy adults (203 females) aged 18-64 years participated in this study. The time required to perform the 6-m gait speed test was recorded simultaneously by a trained (R1) and an untrained (R2) rater (inter-rater reliability), and by photoelectric cells (measurement agreement between timing methods). The test was repeated under the identical conditions (test-retest reliability) 48-72 h later. Systematic error between photoelectric cells and R1 was close to zero (0.015 s), whereas a larger difference was observed for R2 ( approximately 0.2 s). The corresponding concordance correlation coefficients (CCC) were 0.966 and 0.861, respectively. There was a systematic error between R2 and R1 of approximately 0.2 s, with a CCC of 0.872. Test-retest systematic error was -0.047 s (p < 0.01), with an effect size of 0.067. The intraclass correlation coefficient was 0.984, and all error measurements reported low values, except the coefficient of variation that was 14.386. No heteroscedasticity was observed (p > 0.05). Measurement agreements and reliability were not influenced by sex, age groups and physical activity levels. Manual timing by R1 demonstrated high agreement with photoelectric cells and high test-retest reliability for assessing 6-m gait speed test in adults. Rater training is strongly recommended to minimize measurement error. CI - (c) 2026 The Author(s). European Journal of Sport Science published by Wiley-VCH GmbH on behalf of European College of Sport Science. FAU - Castro-Pinero, Jose AU - Castro-Pinero J AUID- ORCID: 0000-0002-7353-0382 AD - Department of Physical Education, Faculty of Education Sciences, GALENO Research Group, University of Cadiz, Puerto Real, Spain. AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. FAU - Marin-Jimenez, Nuria AU - Marin-Jimenez N AUID- ORCID: 0000-0002-0687-7554 AD - Department of Physical Education, Faculty of Education Sciences, GALENO Research Group, University of Cadiz, Puerto Real, Spain. AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. AD - Department of Education, Faculty of Educational Sciences, Health Research Centre, University of Almeria, Almeria, Spain. FAU - Cruz-Leon, Carolina AU - Cruz-Leon C AUID- ORCID: 0000-0001-9070-5693 AD - Department of Physical Education, Faculty of Education Sciences, GALENO Research Group, University of Cadiz, Puerto Real, Spain. AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. FAU - Cies Valleras, Francisco Javier AU - Cies Valleras FJ AUID- ORCID: 0009-0001-1857-1245 AD - Department of Physical Education, Faculty of Education Sciences, GALENO Research Group, University of Cadiz, Puerto Real, Spain. AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. FAU - Borges-Cosic, Milkana AU - Borges-Cosic M AUID- ORCID: 0000-0002-8276-9387 AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Physical Activity for Health Promotion Research Group (PAHELP), University of Granada, Granada, Spain. AD - Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Cadiz, Spain. FAU - Camiletti-Moiron, Daniel AU - Camiletti-Moiron D AUID- ORCID: 0000-0002-8856-5967 AD - Department of Physical Education, Faculty of Education Sciences, GALENO Research Group, University of Cadiz, Puerto Real, Spain. AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. FAU - Cuenca-Garcia, Magdalena AU - Cuenca-Garcia M AUID- ORCID: 0000-0002-8510-9253 AD - Department of Physical Education, Faculty of Education Sciences, GALENO Research Group, University of Cadiz, Puerto Real, Spain. AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. LA - eng GR - DEP2017-88043-R/This project was supported by the Ministry of Economy, Industry and Competitiveness in the 2017 call for R&D Projects of the State Program for Research, Development and Innovation Targeting the Challenges of the Company; National Plan for Scientific and Technical Research and Innovation 2013-2016; the Spanish Ministry of Education, Culture and Sport; Spanish Ministry of Universities, funded by the European Union-NextGenerationEU; "Salvador de Madariaga" Senior Mobility Grant Program from the Ministry of Universities; and the Juan de la Cierva Fellowship from the Spanish Ministry of Science and Innovation./ PT - Journal Article PL - Germany TA - Eur J Sport Sci JT - European journal of sport science JID - 101146739 SB - IM MH - Humans MH - Reproducibility of Results MH - Female MH - Adult MH - Male MH - Young Adult MH - *Walking Speed MH - Middle Aged MH - Adolescent MH - Observer Variation MH - *Exercise Test/methods MH - *Physical Fitness PMC - PMC13587142 OTO - NOTNLM OT - adults OT - field-based test OT - measurement concordance OT - motor fitness OT - physical fitness OT - reproducibility COIS- The authors declare no conflicts of interest. EDAT- 2026/09/18 12:25 MHDA- 2026/09/18 12:26 PMCR- 2026/09/18 CRDT- 2026/09/18 09:08 PHST- 2026/05/23 00:00 [revised] PHST- 2025/11/06 00:00 [received] PHST- 2026/06/07 00:00 [accepted] PHST- 2026/09/18 12:26 [medline] PHST- 2026/09/18 12:25 [pubmed] PHST- 2026/09/18 09:08 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - EJSC70207 [pii] AID - 10.1002/ejsc.70207 [doi] PST - ppublish SO - Eur J Sport Sci. 2026 Oct;26(10):e70207. doi: 10.1002/ejsc.70207. PMID- 42757245 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20260919 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Activity-function transitions and interpretable machine learning for predicting incident depressive symptoms among ACE-exposed middle-aged and older adults: a multi-cohort study. PG - 1924836 LID - 10.3389/fpubh.2026.1924836 [doi] LID - 1924836 AB - BACKGROUND: Ad--verse childhood experiences (ACEs) are associated with increased risk of depressive symptoms in later life. This study aimed to develop and externally validate an interpretable machine-learning model for predicting incident depressive symptoms among ACE-exposed middle-aged and older adults. METHODS: Data were obtained from the English Longitudinal Study of Aging (ELSA) and the Health and Retirement Study (HRS). Participants with baseline depressive symptoms were excluded. ELSA was used for model development and HRS for external validation. LASSO regression was applied for predictor selection, followed by comparison of multiple machine-learning algorithms. Pre-outcome activity-function transition profiles were further examined in relation to observed incident depressive symptoms. RESULTS: LASSO identified stable predictors mainly involving physical function, physical activity, chronic conditions, and sociodemographic characteristics. Among the evaluated models, random forest demonstrated the best performance, with an AUC of 0.701 in ELSA and 0.693 in HRS external validation. SHAP analysis identified walking time, grip strength, falls, arthritis, and physical activity as important contributors to prediction. Participants with unfavorable activity-function status at both pre-outcome assessments showed higher odds of incident depressive symptoms in both cohorts. CONCLUSION: An interpretable machine-learning framework integrating physical performance, physical activity, and health-related factors achieved moderate and externally validated prediction of incident depressive symptoms among ACE-exposed adults. Pre-outcome activity-function transition profiles provided additional information on subsequent depressive-symptom risk. Given the moderate discrimination and limited case-detection ability, the framework should be regarded as exploratory and requires further validation and refinement before any clinical application. CI - Copyright (c) 2026 Lin, Shangguan, Sim, Chen and Wang. FAU - Lin, Zhenhao AU - Lin Z AD - Department of Pediatrics, Binhai County People's Hospital, Yancheng, Jiangsu, China. AD - Department of Exercise Physiology, Kunsan National University, Gunsan, Republic of Korea. FAU - Shangguan, Yuwen AU - Shangguan Y AD - Department of Exercise Physiology, Kunsan National University, Gunsan, Republic of Korea. AD - School of Rehabilitation Medicine, Jining Medical University, Jining, Shandong, China. FAU - Sim, Young-Je AU - Sim YJ AD - Department of Exercise Physiology, Kunsan National University, Gunsan, Republic of Korea. FAU - Chen, Dahua AU - Chen D AD - Department of Exercise Physiology, Kunsan National University, Gunsan, Republic of Korea. FAU - Wang, Xiang AU - Wang X AD - Department of Pediatrics, Binhai County People's Hospital, Yancheng, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260903 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - *Depression/epidemiology MH - *Machine Learning MH - Male MH - Middle Aged MH - Aged MH - Longitudinal Studies MH - *Adverse Childhood Experiences/statistics & numerical data/psychology MH - Predictive Learning Models MH - *Exercise/psychology MH - Incidence MH - Risk Factors MH - Prediction Algorithms PMC - PMC13584956 OTO - NOTNLM OT - adverse childhood experiences OT - depression OT - longitudinal cohort OT - machine learning OT - middle-aged and older adults OT - physical activity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/18 12:26 MHDA- 2026/09/18 12:27 PMCR- 2026/09/03 CRDT- 2026/09/18 08:37 PHST- 2026/07/01 00:00 [received] PHST- 2026/07/27 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/09/18 12:27 [medline] PHST- 2026/09/18 12:26 [pubmed] PHST- 2026/09/18 08:37 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1924836 [doi] PST - epublish SO - Front Public Health. 2026 Sep 3;14:1924836. doi: 10.3389/fpubh.2026.1924836. eCollection 2026. PMID- 42756624 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260918 LR - 20260919 IS - 1728-869X (Print) IS - 2226-5104 (Electronic) IS - 1728-869X (Linking) VI - 24 IP - 4 DP - 2026 Oct TI - Evaluation of the Government indicator methodology in the Global Matrix on physical activity for children and adolescents. PG - 200520 LID - 10.1016/j.jesf.2026.200520 [doi] LID - 200520 AB - BACKGROUND/OBJECTIVES: The Government indicator evaluates national policies and strategies for child and adolescent physical activity, supporting country reporting and international comparisons within the Global Matrix initiative. To grade this indicator, countries/jurisdictions apply either the original method or, in recent editions, an alternative approach. The alternative approach was proposed by the Welsh team, who derived six criteria from the World Health Organization's Health-Enhancing Physical Activity Policy Audit Tool v2 and developed an accompanying scoring rubric. This study aimed to evaluate the Welsh approach in comparison with the original method to guide recommendations for future applications. METHODS: The study employed a mixed-methods design, including: 1) inductive content analysis of feedback collected via survey from 17 researchers and policy professionals from various countries, and 2) descriptive and Wilcoxon signed-rank analysis of Government indicator grades from Global Matrices 3.0 and 4.0 in 6 countries that transitioned to the Welsh approach and 28 countries/jurisdictions that retained the original method. RESULTS: User feedback on the Welsh approach was predominantly positive, noting its structure, transparency, and comprehensiveness as strengths, and indicating greater utility and suitability than the original method. Concerns included limited consideration of policy implementation and feasibility aspects. No statistically significant group-level temporal grade differences were found for both methods. CONCLUSION: The Welsh approach adds structure and transparency to the Government indicator assessment. Further refinements to the Welsh approach may improve comparability and policy relevance, while both the Welsh and original methods remain acceptable for interim use within the Global Matrix, with potential applicability beyond it. CI - (c) 2026 The Society of Chinese Scholars on Exercise Physiology and Fitness. Published by Elsevier B.V. FAU - Demchenko, Iryna AU - Demchenko I AD - Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. AD - Department of Health Sciences, Carleton University, Ottawa, ON, Canada. AD - Active Healthy Kids Global Alliance, Ottawa, ON, Canada. FAU - Aubert, Salome AU - Aubert S AD - Active Healthy Kids Global Alliance, Ottawa, ON, Canada. FAU - Kuzik, Nicholas AU - Kuzik N AD - Faculty of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. FAU - Edwards, Lowri C AU - Edwards LC AD - Cardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Wales, UK. FAU - Ward, Malcolm AU - Ward M AD - Applied Sports Technology, Exercise and Medicine Research Centre (A-STEM), Swansea University, Wales, UK. FAU - Arbour-Nicitopoulos, Kelly P AU - Arbour-Nicitopoulos KP AD - Faculty of Kinesiology and Physical Education, University of Toronto, Toronto, ON, Canada. FAU - Brazo-Sayavera, Javier AU - Brazo-Sayavera J AD - Department of Sports and Computer Science, Universidad Pablo de Olavide, Seville, Spain. FAU - Cortinez-O'Ryan, Andrea AU - Cortinez-O'Ryan A AD - Department of Physical Education, Sports and Recreation, Universidad de La Frontera, Temuco, Chile. AD - School of Kinesiology, Faculty of Medical Sciences, Universidad de Santiago de Chile, Chile. FAU - De Roia, Gabriela AU - De Roia G AD - Laboratorio de Estudios en Actividad Fisica (LEAF), Universidad de Flores, CABA, Argentina. FAU - Gonzalez, Silvia A AU - Gonzalez SA AD - School of Medicine, Universidad de los Andes, Bogota, Colombia. FAU - Guisihan, Roselle M AU - Guisihan RM AD - Institute of Clinical Epidemiology, National Institutes of Health, University of the Philippines Manila, Manila City, Philippines. FAU - Jeon, Justin Y AU - Jeon JY AD - Department of Sport Industry Studies, Center for Exercise Medicine and Salutogenesis, Yonsei University, Seoul, South Korea. FAU - Kim, Yeon Soo AU - Kim YS AD - Department of Physical Education, Institute of Sports Science, Seoul National University, Seoul, South Korea. FAU - Poh, Bee Koon AU - Poh BK AD - Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. FAU - Slancova, Terezia Kovalik AU - Slancova TK AD - University of Presov, Faculty of Sports, Presov, Slovakia. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Ecuador. AD - Faculty of Health Sciences, Universidad Autonoma de Chile, Temuco, Chile. FAU - Ng, Kwok AU - Ng K AD - Physical Activity for Health Research Centre, Health Research Institute & Department of Physical Education and Sport Sciences, University of Limerick, Limerick, Ireland. AD - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, Lithuania. AD - Department of Teacher Education, Turku Institute of Advanced Studies, University of Turku, Turku, Finland. FAU - Palad, Yves AU - Palad Y AD - Department of Physical Therapy, College of Allied Medical Professions, University of the Philippines, Manila, Philippines. FAU - Silva, Diego Augusto Santos AU - Silva DAS AD - Department of Physical Education, Sports Center, Federal University of Santa Catarina, Florianopolis, SC, Brazil. FAU - Tomaz, Simone A AU - Tomaz SA AD - Faculty of Health Sciences and Sport, University of Stirling, Stirling, Scotland, UK. FAU - Urbanski, Piotr Kazimierz AU - Urbanski PK AD - Department of Adapted Physical Activity, Poznan University of Physical Education, Poznan, Poland. FAU - Tremblay, Mark S AU - Tremblay MS AD - Healthy Active Living and Obesity Research Group, Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. AD - Department of Health Sciences, Carleton University, Ottawa, ON, Canada. AD - Active Healthy Kids Global Alliance, Ottawa, ON, Canada. AD - Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada. LA - eng PT - Journal Article DEP - 20260905 PL - Singapore TA - J Exerc Sci Fit JT - Journal of exercise science and fitness JID - 101198241 PMC - PMC13583972 OTO - NOTNLM OT - International benchmarking OT - Measurement OT - Policy OT - Youth COIS- ID was an AHKGA Fellow, and SA, JBS, DASS, and MST were members of the AHKGA Board of Directors during the conduct of this study. LCE and MW were part of the expert team that developed the Welsh approach. All other authors declare no competing interests. EDAT- 2026/09/18 12:26 MHDA- 2026/09/18 12:27 PMCR- 2026/09/05 CRDT- 2026/09/18 07:40 PHST- 2026/05/03 00:00 [received] PHST- 2026/08/14 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/18 12:27 [medline] PHST- 2026/09/18 12:26 [pubmed] PHST- 2026/09/18 07:40 [entrez] PHST- 2026/09/05 00:00 [pmc-release] AID - S1728-869X(26)00081-X [pii] AID - 200520 [pii] AID - 10.1016/j.jesf.2026.200520 [doi] PST - ppublish SO - J Exerc Sci Fit. 2026 Oct;24(4):200520. doi: 10.1016/j.jesf.2026.200520. Epub 2026 Sep 5. PMID- 42756357 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260918 LR - 20260919 IS - 2048-7177 (Print) IS - 2048-7177 (Electronic) IS - 2048-7177 (Linking) VI - 14 IP - 9 DP - 2026 Sep TI - Identification of Antileukemic Compound From Ginger by Integrating UHPLC-MS, Network Pharmacology, Molecular Docking, Molecular Dynamics Simulation, and In Vitro and In Vivo Experimental Validation. PG - e72379 LID - 10.1002/fsn3.72379 [doi] LID - e72379 AB - Acute myeloid leukemia (AML) is a prevalent pediatric hematologic malignancy associated with a poor clinical prognosis, largely due to drug-induced toxicity, the emergence of resistance, and frequent disease relapse. Edible plants offer promising complementary therapeutic approaches through their bioactive compounds, which are characterized by favorable safety profiles. Zingiber officinale (ginger), commonly consumed both as a dietary component and as a traditional medicinal herb, has garnered increasing scientific interest; however, its potential antileukemic properties remain largely unexplored. Crude extracts from four ginger cultivars exhibited antileukemic activity in AML cells. Metabolomic profiling was used to screen for candidate constituents, and Arctigenin was selected for further investigation. Its presence in the ginger extracts was verified by targeted UHPLC-MS analysis using an authentic standard, followed by evaluation of its antileukemic activity. Arctigenin showed potent and selective cytotoxicity against AML cells, particularly HL60 cells. Network pharmacology was employed to predict potential molecular targets, followed by molecular docking and 100-ns molecular dynamics simulations to evaluate potential interactions, suggesting PARP1 and NFkappaB1 as potential molecular targets. Experimental analyses further demonstrated that Arctigenin induced apoptosis and altered NFkappaB and PARP protein expression in AML cells. In vivo experiments demonstrated that Arctigenin significantly suppressed tumor growth in an AML xenograft mouse model, achieving efficacy comparable to that of cytarabine, without inducing hepatosplenic toxicity or metabolic disturbances. These findings provide the first evidence supporting ginger as a novel phytochemical resource for AML therapy and support Arctigenin as a promising antileukemic candidate, underscoring its potential for incorporation into food-based or plant-derived therapeutic strategies. CI - (c) 2026 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC. FAU - Huang, Mengjun AU - Huang M AD - National-Local Joint Engineering Research Center for Innovative Targeted Drugs Chongqing University of Arts and Sciences Chongqing P. R. China. FAU - Liu, Jing AU - Liu J AD - Department of Pediatric Hematologic Oncology and Respiratory Children's Medical Center, The Affiliated Hospital, Southwest Medical University, Sichuan Clinical Research Center for Birth Defects, Southwest Medical University Luzhou Sichuan P. R. China. FAU - Zeng, Kaixuan AU - Zeng K AUID- ORCID: 0009-0002-0681-5588 AD - Pediatrics Department Southwest Medical University Luzhou Sichuan P. R. China. FAU - Xu, Lianling AU - Xu L AD - Pediatrics Department Southwest Medical University Luzhou Sichuan P. R. China. FAU - Liu, Yangchun AU - Liu Y AUID- ORCID: 0009-0006-4091-4829 AD - Pediatrics Department Southwest Medical University Luzhou Sichuan P. R. China. FAU - Xie, Linyun AU - Xie L AD - Pediatrics Department Southwest Medical University Luzhou Sichuan P. R. China. FAU - Shi, Mengni AU - Shi M AUID- ORCID: 0009-0007-1062-6209 AD - Department of Clinical Medicine, School of Clinical Medicine Southwest Medical University Luzhou Sichuan P. R. China. FAU - Zeng, Yan AU - Zeng Y AD - Department of Pediatric Hematologic Oncology and Respiratory Children's Medical Center, The Affiliated Hospital, Southwest Medical University, Sichuan Clinical Research Center for Birth Defects, Southwest Medical University Luzhou Sichuan P. R. China. FAU - Liu, Wenjun AU - Liu W AUID- ORCID: 0000-0002-7205-0598 AD - Department of Pediatric Hematologic Oncology and Respiratory Children's Medical Center, The Affiliated Hospital, Southwest Medical University, Sichuan Clinical Research Center for Birth Defects, Southwest Medical University Luzhou Sichuan P. R. China. FAU - Guo, Ling AU - Guo L AUID- ORCID: 0000-0003-1986-3175 AD - Department of Pediatric Hematologic Oncology and Respiratory Children's Medical Center, The Affiliated Hospital, Southwest Medical University, Sichuan Clinical Research Center for Birth Defects, Southwest Medical University Luzhou Sichuan P. R. China. AD - Pediatrics Department Southwest Medical University Luzhou Sichuan P. R. China. LA - eng PT - Journal Article DEP - 20260916 PL - United States TA - Food Sci Nutr JT - Food science & nutrition JID - 101605473 PMC - PMC13583061 OTO - NOTNLM OT - acute myeloid leukemia OT - arctigenin OT - ginger OT - molecular dynamics simulation OT - network pharmacology COIS- The authors declare no conflicts of interest. EDAT- 2026/09/18 12:25 MHDA- 2026/09/18 12:26 PMCR- 2026/09/16 CRDT- 2026/09/18 07:15 PHST- 2025/12/31 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/09/18 12:26 [medline] PHST- 2026/09/18 12:25 [pubmed] PHST- 2026/09/18 07:15 [entrez] PHST- 2026/09/16 00:00 [pmc-release] AID - FSN372379 [pii] AID - 10.1002/fsn3.72379 [doi] PST - epublish SO - Food Sci Nutr. 2026 Sep 16;14(9):e72379. doi: 10.1002/fsn3.72379. eCollection 2026 Sep. PMID- 42756176 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260918 LR - 20260919 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 17 DP - 2026 TI - Age-specific alterations in gut microbiota-plasma metabolome networks in first-episode, drug-naive major depressive disorder: adolescent versus adult patients. PG - 1922527 LID - 10.3389/fmicb.2026.1922527 [doi] LID - 1922527 AB - BACKGROUND: Major depressive disorder (MDD) exhibits pronounced age-related pathophysiological heterogeneity, yet the distinct signatures of the microbiota-gut-brain (MGB) axis between adolescent and adult patients remain inadequately characterized. This study aimed to elucidate age-specific MGB axis dysregulation by integrating gut microbiota profiling, plasma metabolomics, and their interactive networks in first-episode, drug-naive MDD patients across these two developmental stages. METHODS: We enrolled 62 first-episode, drug-naive MDD patients (28 adolescents, 34 adults) alongside 43 age- and sex-matched healthy controls (22 adolescents, 21 adults). Fecal samples underwent 16S rRNA gene sequencing, while plasma was analyzed via untargeted metabolomics. Comprehensive bioinformatics and network analyses were applied to map microbial compositional shifts, metabolic perturbations, and microbe-metabolite crosstalks. RESULTS: Integrated multi-omics analysis revealed distinct age-specific gut microbiota and plasma metabolome signatures in TMDD and AMDD compared with their age-matched controls. 1 in circle Microbiota: Beyond shared depletion of Firmicutes and butyrate-producing genera (Anaerobutyricum, Blautia), TMDD exhibited more extensive remodeling. Characterized by increased (Chao1 index, p < 0.05) Bifidobacterium loss and enrichment of Bacteroidetes, Gemmatimonadetes, and Planctomycetes. 2 in circle Metabolome: TMDD perturbations targeted neurodevelopmental and oxidative pathways, such as arginine/proline metabolism, D-amino acid metabolism, and glutathione metabolism. Whereas AMDD focused on energy dysfunction and excitotoxicity, involving the TCA cycle, purine metabolism, and alanine/aspartate/glutamate metabolism. 3 in circle Interactome: In AMDD, positive correlations with protective (lipids) were attenuated, while pathological links with pro-inflammatory sphingolipids and polyamines strengthened. The interactome in AMDD remained stable. CONCLUSION: Our findings suggest that first-episode, drug-naive MDD patients display distinct age-specific dysregulation of the microbiota-gut-plasma metabolome axis. The non-overlapping pathological signatures, a "development-nutrition-metabolic" disturbance pattern in adolescents versus an "energy metabolism-oxidative stress" pattern in adults, underscore the pronounced pathophysiological heterogeneity of MDD across the lifespan. These preliminary observations indicate that future diagnostic biomarkers and therapeutic interventions, particularly microbiota-targeted strategies, should be precisely tailored to the biological profiles of different age groups. However, given the exploratory nature of this subtyping, larger independent cohort studies are warranted to validate these findings before clinical translation. CI - Copyright (c) 2026 Mo, Chai, Zhao, Wang, Zhang, Miaoyang, Wang, Lu and Wang. FAU - Mo, Hui AU - Mo H AD - Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China. FAU - Chai, Dan AU - Chai D AD - Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China. FAU - Zhao, LeTian AU - Zhao L AD - Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China. FAU - Wang, Jun AU - Wang J AD - Department of Hygienic Analysis and Detection, Center for Global Health, Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Zhang, Qiang AU - Zhang Q AD - School of Automation and Intelligent Sensing, Shanghai Jiaotong University, Shanghai, China. FAU - Miaoyang, Hu AU - Miaoyang H AD - Department of Hygienic Analysis and Detection, Center for Global Health, Key Laboratory of Modern Toxicology, Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Wang, Ting AU - Wang T AD - Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China. FAU - Lu, WeiMin AU - Lu W AD - Jiangsu Province Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, China. FAU - Wang, Changqing AU - Wang C AD - Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260903 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC13582463 OTO - NOTNLM OT - age heterogeneity OT - gut microbiota OT - major depressive disorder OT - metabolomics OT - microbiota-gut-brain axis COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/18 12:25 MHDA- 2026/09/18 12:26 PMCR- 2026/09/03 CRDT- 2026/09/18 06:52 PHST- 2026/06/30 00:00 [received] PHST- 2026/07/27 00:00 [revised] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/09/18 12:26 [medline] PHST- 2026/09/18 12:25 [pubmed] PHST- 2026/09/18 06:52 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - 10.3389/fmicb.2026.1922527 [doi] PST - epublish SO - Front Microbiol. 2026 Sep 3;17:1922527. doi: 10.3389/fmicb.2026.1922527. eCollection 2026. PMID- 42756134 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260918 LR - 20260919 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Beyond oxygen targets: the DOSE framework as a conceptual model for dynamic oxygen stewardship in retinopathy of prematurity. PG - 1882831 LID - 10.3389/fped.2026.1882831 [doi] LID - 1882831 AB - Retinopathy of prematurity (ROP) remains a major cause of preventable childhood blindness, and oxygen therapy continues to represent a central but complex component of neonatal care. Current oxygen management is largely guided by static peripheral oxygen saturation (SpO(2)) target ranges, commonly around 90%-95%. However, target ranges alone may not fully capture the dynamic nature of oxygen exposure in preterm infants, including fluctuations, intermittent hypoxemia, hyperoxemic excursions, instability, and cumulative exposure over time. We propose the Dynamic Oxygen Stability and Exposure (DOSE) framework as a conceptual and hypothesis-generating model for dynamic oxygen stewardship in ROP prevention. DOSE integrates four interconnected domains: delivered oxygen input (dose), physiologic oxygenation output reflected by the SpO(2) response, oxygen stability or fluctuation control, and cumulative oxygen exposure over time. The novelty of DOSE does not lie in claiming that these individual elements are new, but in organizing them into a unified framework that may help explain why similar SpO(2) targets can produce different biologic oxygen experiences across infants and care settings. This framework does not replace existing oxygen saturation guidelines and is not yet a validated clinical score or predictive model. Rather, it provides a structured approach for future research, quality improvement, and prospective validation of dynamic oxygen-exposure metrics. DOSE also recognizes that ROP is multifactorial and that oxygen instability should be interpreted alongside prematurity severity, postnatal growth, inflammation, transfusion, nutrition, respiratory morbidity, screening access, and treatment availability. By shifting attention from static targets alone toward oxygen stability and cumulative exposure, DOSE may support future strategies for safer and more individualized oxygen stewardship in diverse neonatal settings. CI - (c) 2026 Siswanto. FAU - Siswanto, Johanes Edy AU - Siswanto JE AD - Department of Neonatology, Harapan Kita National Women and Children Health Centre, Jakarta, Indonesia. AD - Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia. LA - eng PT - Journal Article DEP - 20260903 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13582581 OTO - NOTNLM OT - DOSE framework OT - dynamic oxygen exposure OT - low- and middle-income countries OT - oxygen instability OT - oxygen saturation OT - oxygen stewardship OT - oxygen therapy OT - retinopathy of prematurity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/18 12:25 MHDA- 2026/09/18 12:26 PMCR- 2026/09/03 CRDT- 2026/09/18 06:49 PHST- 2026/05/16 00:00 [received] PHST- 2026/07/12 00:00 [revised] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/09/18 12:26 [medline] PHST- 2026/09/18 12:25 [pubmed] PHST- 2026/09/18 06:49 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - 10.3389/fped.2026.1882831 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 3;14:1882831. doi: 10.3389/fped.2026.1882831. eCollection 2026. PMID- 42756052 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260918 LR - 20260919 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Physical activity and health-related quality of life among Chinese adolescents: a cross-sectional statistical path model involving sleep disturbance and depressive symptoms. PG - 1954434 LID - 10.3389/fped.2026.1954434 [doi] LID - 1954434 AB - OBJECTIVE: Physical activity (PA) is positively associated with health-related quality of life (HRQoL) in adolescents, while sleep disturbance and depressive symptoms are also closely related to both PA and HRQoL. However, relatively few studies have examined these factors simultaneously, particularly among Chinese adolescents. This study examined the association between PA and HRQoL and assessed the separate and serial indirect associations involving sleep disturbance and depressive symptoms. METHODS: A cross-sectional survey was conducted among 2,202 secondary-school students from 12 schools in China. Participants completed validated self-report measures of PA, sleep disturbance, depressive symptoms, and HRQoL. Pearson correlations were used to examine bivariate associations, and a serial multiple-mediator model (PROCESS Model 6) was applied to estimate direct and indirect associations. Statistical uncertainty was evaluated using 5,000 bootstrap resamples and bias-corrected 95% confidence intervals (CIs). RESULTS: Higher PA was associated with lower sleep disturbance and depressive symptoms and with better HRQoL. Sleep disturbance was positively associated with depressive symptoms, whereas both sleep disturbance and depressive symptoms were inversely associated with HRQoL. The standardized total association between PA and HRQoL was 0.324 [95% CI (0.288, 0.358)], of which 0.095 was statistically accounted for by the combined indirect associations. Significant specific indirect associations were observed through sleep disturbance alone [beta = 0.032, 95% CI (0.019, 0.046)], depressive symptoms alone [beta = 0.046, 95% CI (0.034, 0.058)], and the sequential pathway involving sleep disturbance followed by depressive symptoms [beta = 0.017, 95% CI (0.013, 0.022)]. The direct PA-HRQoL association remained significant after both statistical mediators were included [beta = 0.229, 95% CI (0.191, 0.265)]. CONCLUSIONS: PA, sleep disturbance, depressive symptoms, and HRQoL were closely interconnected among Chinese adolescents. Sleep- and mood-related factors statistically accounted for part of the positive association between PA and HRQoL, with depressive symptoms showing the largest specific indirect association. These findings support considering PA, sleep health, and emotional well-being within an integrated adolescent health framework. Because all variables were measured concurrently, the observed indirect associations should not be interpreted as evidence of temporal or causal mediation. CI - (c) 2026 Liu. FAU - Liu, Mengxuan AU - Liu M AD - School of Physical Education, Jiangxi Institute of Technology, Nanchang, China. LA - eng PT - Journal Article DEP - 20260903 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13582418 OTO - NOTNLM OT - China OT - adolescents OT - depressive symptoms OT - health-related quality of life OT - physical activity OT - sleep disturbance OT - statistical association COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/18 12:25 MHDA- 2026/09/18 12:26 PMCR- 2026/09/03 CRDT- 2026/09/18 06:37 PHST- 2026/07/31 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/20 00:00 [accepted] PHST- 2026/09/18 12:26 [medline] PHST- 2026/09/18 12:25 [pubmed] PHST- 2026/09/18 06:37 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - 10.3389/fped.2026.1954434 [doi] PST - epublish SO - Front Pediatr. 2026 Sep 3;14:1954434. doi: 10.3389/fped.2026.1954434. eCollection 2026. PMID- 42755577 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260918 LR - 20260919 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Predicting extrauterine growth restriction at the parenteral-enteral nutrition transition: a model for risk identification in very preterm infants. PG - 1788647 LID - 10.3389/fnut.2026.1788647 [doi] LID - 1788647 AB - INTRODUCTION: This study aims to identify the key predictors of longitudinal extrauterine growth restriction (EUGR) in very preterm infants during the parenteral-to-enteral nutrition transition and subsequently develop an effective predictive model for early clinical identification. METHODS: A total of 260 infants born at 28-31(+6) weeks of gestation were included in this retrospective study. Perinatal and early postnatal clinical data were collected. The univariate regression analysis (p < 0.1) and LASSO algorithms were employed to comprehensively screen for variables. The screened variables were utilized to construct the optimal model. The development of an optimal predictive model involved performance comparison and validation across five algorithms, including logistic regression and four machine learning algorithms. This process was coupled with an explanation of machine learning algorithms using the Shapley Additive exPlanations (SHAP) to ensure interpretability. RESULTS: The study identified six key predictors: gestational age, sex, time to regain birth weight, gestational diabetes, hypertensive disorders of pregnancy and blood urea nitrogen. Among the models compared, the logistic regression model exhibited the best performance, and the nomogram developed from this model demonstrated strong predictive efficacy. CONCLUSION: In this study, we developed and internally validated a prediction model for longitudinal EUGR in very preterm infants specifically during the parenteral-to-enteral transition. The model demonstrated robust predictive performance, strong clinical utility, and exceptional interpretability. It offers a practical tool for risk stratification during the parenteral-to-enteral transition, enabling clinicians to identify high-risk infants who may benefit from timely, personalized nutritional support. CI - Copyright (c) 2026 Wu, Zhou, Hu, Chen, Huang, Zhang and Xiu. FAU - Wu, Zhenyuan AU - Wu Z AD - Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. AD - Fujian Clinical Research Center for Maternal-Fetal Medicine, Fuzhou, Fujian, China. AD - National Key Obstetric Clinical Specialty Construction Institution of China, Fuzhou, Fujian, China. FAU - Zhou, Dan AU - Zhou D AD - Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. AD - Fujian Clinical Research Center for Maternal-Fetal Medicine, Fuzhou, Fujian, China. AD - National Key Obstetric Clinical Specialty Construction Institution of China, Fuzhou, Fujian, China. FAU - Hu, Yanhua AU - Hu Y AD - Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. AD - Fujian Clinical Research Center for Maternal-Fetal Medicine, Fuzhou, Fujian, China. AD - National Key Obstetric Clinical Specialty Construction Institution of China, Fuzhou, Fujian, China. FAU - Chen, Rong AU - Chen R AD - Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. AD - Fujian Clinical Research Center for Maternal-Fetal Medicine, Fuzhou, Fujian, China. AD - National Key Obstetric Clinical Specialty Construction Institution of China, Fuzhou, Fujian, China. FAU - Huang, Min AU - Huang M AD - Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. AD - Fujian Clinical Research Center for Maternal-Fetal Medicine, Fuzhou, Fujian, China. AD - National Key Obstetric Clinical Specialty Construction Institution of China, Fuzhou, Fujian, China. FAU - Zhang, Baoquan AU - Zhang B AD - Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. AD - Fujian Clinical Research Center for Maternal-Fetal Medicine, Fuzhou, Fujian, China. AD - National Key Obstetric Clinical Specialty Construction Institution of China, Fuzhou, Fujian, China. FAU - Xiu, Wenlong AU - Xiu W AD - Department of Neonatology, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. AD - Fujian Clinical Research Center for Maternal-Fetal Medicine, Fuzhou, Fujian, China. AD - National Key Obstetric Clinical Specialty Construction Institution of China, Fuzhou, Fujian, China. LA - eng PT - Journal Article DEP - 20260903 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13581580 OTO - NOTNLM OT - Fenton 2013 OT - logistic regression OT - machine learning OT - restricted growth OT - very preterm COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/18 12:25 MHDA- 2026/09/18 12:26 PMCR- 2026/09/03 CRDT- 2026/09/18 05:22 PHST- 2026/01/15 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/18 12:26 [medline] PHST- 2026/09/18 12:25 [pubmed] PHST- 2026/09/18 05:22 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - 10.3389/fnut.2026.1788647 [doi] PST - epublish SO - Front Nutr. 2026 Sep 3;13:1788647. doi: 10.3389/fnut.2026.1788647. eCollection 2026. PMID- 42754870 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20260922 IS - 1741-7015 (Electronic) IS - 1741-7015 (Linking) VI - 24 IP - 1 DP - 2026 Sep 11 TI - Effectiveness of structured lactation support and human donor milk banking in German NICUs: a stepped-wedge cluster-randomized trial. LID - 10.1186/s12916-026-05211-1 [doi] LID - 504 AB - BACKGROUND: Although exclusive human milk feeding is beneficial for very low birth weight infants, rates remain suboptimal globally. This hybrid type 1 effectiveness-implementation trial evaluated structured lactation support combined with human donor milk banking in neonatal intensive care units (NICUs), primarily assessing effectiveness, with secondary assessment of implementation and economic outcomes. METHODS: We conducted a stepped-wedge cluster-randomized trial in 15 German Level I NICUs (April 2022-March 2024). The Neo-MILK intervention comprised structured lactation counselling, multilingual materials, mobile app support for mothers/parents, and human donor milk banking. Implementation strategies included video-based staff training, guidelines, commitment nudges for medical staff, and support for human donor milk bank establishment. The primary outcome was exclusive mother's own milk feeding at NICU discharge. Secondary outcomes included feeding status categories, clinical complications, length of stay, and maternal outcomes. Implementation outcomes were acceptability, feasibility, appropriateness, fidelity, and sustainability. Prespecified subgroup analyses examined birth weight (< 1,000 g vs. >/=1,000 g) and illness severity (CRIB >/= 11 vs. <11). Economic evaluation employed time-driven activity-based costing and budget impact analysis. RESULTS: Among 1,627 very low birth weight infants (831 intervention, 796 control), the intervention increased exclusive mother's own milk feeding at discharge by 11%-points (95% CI: 3.0 to 19.0; p = 0.007) from a 43% baseline. Exclusive formula feeding decreased correspondingly. Subgroup analyses showed no significant effects in extremely low birth weight infants (< 1,000 g) or high-risk infants (CRIB >/= 11). Clinical complications and length of stay showed no differences. Acceptability, appropriateness, and feasibility were high. Fidelity was sufficient, with prepartal counselling delivered as intended in 71% of cases. Human donor milk banks were established in 40% of sites. Sustainability indicators were promising, with 61% of staff reporting routine integration. Economic evaluation suggested potential net savings nationally in the base-case scenario. CONCLUSIONS: Structured lactation support with human donor milk banking increased exclusive mother's own milk feeding across Level I NICUs, with no observed increase in complications or costs. Implementation appeared feasible, with indications of sustainability. Variable uptake and differential effects in highest-risk subgroups highlight the need for ongoing organizational support and tailored strategies to further optimize effectiveness. CLINICAL TRIAL REGISTRATION: German Clinical Trials Register DRKS00025058. CI - (c) 2026. The Author(s). FAU - Koberlein-Neu, Juliane AU - Koberlein-Neu J AUID- ORCID: 0000-0002-3451-7847 AD - Centre for Health Economics and Health Services Research, University of Wuppertal, Rainer-Gruenter-Str. 21, 42119, Wuppertal, Germany. koeberlein@wiwi.uni-wuppertal.de. FAU - Dymek, Nicola Gabriela AU - Dymek NG AUID- ORCID: 0009-0005-3594-2617 AD - Centre for Health Economics and Health Services Research, University of Wuppertal, Rainer-Gruenter-Str. 21, 42119, Wuppertal, Germany. FAU - Zimmer, Viola AU - Zimmer V AUID- ORCID: 0009-0008-0580-2463 AD - Centre for Health Economics and Health Services Research, University of Wuppertal, Rainer-Gruenter-Str. 21, 42119, Wuppertal, Germany. FAU - Bommhardt, Trutz AU - Bommhardt T AUID- ORCID: 0009-0007-1748-1073 AD - Centre for Health Economics and Health Services Research, University of Wuppertal, Rainer-Gruenter-Str. 21, 42119, Wuppertal, Germany. FAU - Stirner, Anna Katharina AU - Stirner AK AUID- ORCID: 0009-0005-0429-9112 AD - Department of Business Administration and Health Care Management, University of Cologne, Cologne, Germany. FAU - Guldenring, Isabella AU - Guldenring I AUID- ORCID: 0000-0003-0476-2814 AD - Department for Psychosomatic Medicine and Psychotherapy, Centre for Health Services Research and Communication (CHSR), University Hospital Bonn, Bonn, Germany. FAU - Ohnhauser, Tim AU - Ohnhauser T AD - Faculty of Medicine and University Hospital Cologne, Institute of Medical Sociology, Health Services Research and Rehabilitation Science, Chair of Health Services Research, University of Cologne, Cologne, Germany. FAU - Wiesen, Daniel AU - Wiesen D AUID- ORCID: 0000-0003-4627-1730 AD - Department of Business Administration and Health Care Management, University of Cologne, Cologne, Germany. AD - Erasmus School of Health Policy and Management (ESHPM), Erasmus University Rotterdam, Rotterdam, Netherlands. FAU - Dresbach, Till AU - Dresbach T AUID- ORCID: 0000-0001-7074-7933 AD - Department of Neonatology, University Hospital Bonn, Bonn, Germany. FAU - Scholten, Nadine AU - Scholten N AUID- ORCID: 0000-0002-7793-7745 AD - Department for Psychosomatic Medicine and Psychotherapy, Centre for Health Services Research and Communication (CHSR), University Hospital Bonn, Bonn, Germany. AD - Faculty of Medicine and University Hospital Cologne, Institute of Medical Sociology, Health Services Research and Rehabilitation Science, Chair of Health Services Research, University of Cologne, Cologne, Germany. CN - Neo-MILK Consortium/collaborators LA - eng SI - DRKS/6 May 2021 -DRKS-00025058 PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20260911 PL - England TA - BMC Med JT - BMC medicine JID - 101190723 SB - IM MH - Humans MH - *Milk Banks MH - *Intensive Care Units, Neonatal MH - Germany MH - Female MH - Infant, Newborn MH - *Milk, Human MH - *Lactation MH - *Breast Feeding MH - Adult MH - Infant, Very Low Birth Weight MH - Male PMC - PMC13587408 OTO - NOTNLM OT - Human donor milk OT - Hybrid effectiveness-implementation trial OT - Lactation support OT - Mother's own milk feeding OT - Neonatal care OT - Stepped-wedge cluster-randomized trial OT - Very low birth weight infants COIS- Declarations. Ethics approval and consent to participate: This study has received ethical approval from the Ethics Committee of the Medical Faculty of the University of Cologne (No. 21-1506), the Ethics Committee of the University of Wuppertal (No. 211007) and the local ethics committees of the participating NICUs (without ID). Mothers and NICU staff were given information regarding the study and the data collection, were informed about the voluntary nature, confidentiality, and the possibility of withdrawing at any point. Written consent was obtained from all participants (mothers and NICU staff) before data collection via surveys and qualitative methods. Primary outcome data were extracted from routine medical records under ethics approval, which waived individual consent for anonymized clinical data. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/18 05:36 MHDA- 2026/09/18 05:37 PMCR- 2026/09/11 CRDT- 2026/09/18 00:12 PHST- 2026/03/04 00:00 [received] PHST- 2026/09/04 00:00 [accepted] PHST- 2026/09/18 05:37 [medline] PHST- 2026/09/18 05:36 [pubmed] PHST- 2026/09/18 00:12 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 10.1186/s12916-026-05211-1 [pii] AID - 5211 [pii] AID - 10.1186/s12916-026-05211-1 [doi] PST - epublish SO - BMC Med. 2026 Sep 11;24(1):504. doi: 10.1186/s12916-026-05211-1. PMID- 42754274 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20260925 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 9 DP - 2026 Sep 17 TI - Semaglutide as adjunct treatment for obesity in adolescents receiving antipsychotic medication (the GOAL trial): protocol for a single-arm, open-label feasibility study. PG - e123779 LID - 10.1136/bmjopen-2026-123779 [doi] LID - e123779 AB - INTRODUCTION: Adolescents treated with antipsychotic medication are at increased risk of obesity and metabolic complications, yet evidence-based interventions in this group remain limited. Glucagon-like peptide-1 receptor agonists have demonstrated efficacy in the treatment of obesity in both adults and adolescents. The aim of this trial is to assess the feasibility of a 36-week treatment period with a glucagon-like peptide-1 receptor agonist as an adjunct to standard care in adolescents with antipsychotic-associated obesity, defined as completion from baseline to end of treatment. The findings from this feasibility trial will inform the design and support the scale-up of a subsequent randomised controlled trial. METHODS AND ANALYSIS: The GOAL trial is a single-arm, open-label feasibility study conducted at Copenhagen University Hospital, Bispebjerg, Denmark, in collaboration with the Child and Adolescent Mental Health Center. A total of 34 adolescents aged 12-18 years with obesity, defined as body mass index SD score equal to or greater than +1.28 and body fat percentage at or above the 95th percentile, receiving stable antipsychotic treatment will be enrolled. The study population includes adolescents with a range of psychiatric diagnoses requiring antipsychotic treatment, including psychotic disorders, mood disorders and neurodevelopmental disorders. Adolescents receiving antipsychotic treatment under coercion are excluded. Participants will receive once-weekly subcutaneous semaglutide at a dose up to 2.4 milligrams for 36 weeks in addition to standard care, followed by an 18-month observational follow-up period. The primary outcome is study completion rate. Additional feasibility outcomes include recruitment rate, treatment adherence and completion of study procedures. Secondary outcomes include changes in body mass index SD score, body composition, metabolic biomarkers and psychiatric outcomes. Feasibility outcomes will be analysed descriptively. Exploratory longitudinal analyses will be conducted using linear mixed-effects models. ETHICS AND DISSEMINATION: The study complies with the Declaration of Helsinki and European Union Clinical Trials Regulation (536/2014) and is approved in the Clinical Trials Information System (2024-5 17 471-21-02). Written informed consent will be obtained from participants and their legal guardians. Results will be disseminated through peer-reviewed publications and scientific conferences. TRIAL REGISTRATION NUMBER: 2024-5 17 471-21-02. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Giraldi, Laura Victoria AU - Giraldi LV AD - Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark. FAU - Andersen, Jon Traerup AU - Andersen JT AD - Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Jespersen, Jonas AU - Jespersen J AD - Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark. FAU - Baden, Christoffer Storm AU - Baden CS AD - Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark. FAU - Fonvig, Cilius Esmann AU - Fonvig CE AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. AD - Department of Pediatrics, Copenhagen University Hospital, Holbaek, Denmark. FAU - Riis, Troels AU - Riis T AD - Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark. FAU - Dalhoff, Kim Peder AU - Dalhoff KP AD - Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Holm, Jens-Christian AU - Holm JC AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. AD - Department of Pediatrics, Copenhagen University Hospital, Holbaek, Denmark. FAU - Fink-Jensen, Anders AU - Fink-Jensen A AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. AD - Psychiatric Center Copenhagen, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark. FAU - Pagsberg, Anne Katrine AU - Pagsberg AK AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. AD - Child- and adolescent mental health center Research Unit, Gentofte, Capital Region Mental Health Services, Copenhagen, Denmark. FAU - Christensen, Mikkel Bring AU - Christensen MB AD - Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Gade, Christina AU - Gade C AUID- ORCID: 0000-0002-0007-6158 AD - Department of Clinical Pharmacology, Bispebjerg-Frederiksberg Hospital, Copenhagen, Denmark christina.gade@regionh.dk. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260917 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - 0 (Antipsychotic Agents) RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) RN - 53AXN4NNHX (Semaglutide) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Antipsychotic Agents/administration & dosage MH - Body Mass Index MH - Denmark MH - Feasibility Studies MH - *Glucagon-Like Peptide-1 Receptor Agonists/administration & dosage MH - Mental Disorders/drug therapy MH - *Pediatric Obesity/drug therapy/chemically induced MH - Semaglutide MH - Observational Studies as Topic PMC - PMC13599909 OTO - NOTNLM OT - Adolescent OT - Body Mass Index OT - Child & adolescent psychiatry OT - Clinical Protocols OT - Clinical Trial COIS- Competing interests: None declared. EDAT- 2026/09/17 23:34 MHDA- 2026/09/17 23:35 PMCR- 2026/09/17 CRDT- 2026/09/17 20:42 PHST- 2026/09/17 23:35 [medline] PHST- 2026/09/17 23:34 [pubmed] PHST- 2026/09/17 20:42 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - bmjopen-2026-123779 [pii] AID - 10.1136/bmjopen-2026-123779 [doi] PST - epublish SO - BMJ Open. 2026 Sep 17;16(9):e123779. doi: 10.1136/bmjopen-2026-123779. PMID- 42753886 OWN - NLM STAT- MEDLINE DCOM- 20261028 LR - 20261028 IS - 1872-6240 (Electronic) IS - 0006-8993 (Linking) VI - 1892 DP - 2026 Dec 1 TI - EEG neurofeedback for children with overweight and obesity: A proof-of-concept study. PG - 150554 LID - S0006-8993(26)00416-6 [pii] LID - 10.1016/j.brainres.2026.150554 [doi] AB - OBJECTIVE: Current treatment options for childhood overweight and obesity do not sufficiently address underlying neurophysiological disturbances, such as deviations in electroencephalography (EEG)-measured brain activity, which may account for weight loss failure. Therefore, the present proof-of-concept study estimated effects of food-cue based EEG neurofeedback for reducing high beta band activity in 8-14-year-old children with overweight/obesity (OO). As secondary outcomes, eating disorder psychopathology, food preferences, self-regulation, quality of life, body mass index, feasibility and acceptance were analyzed. METHODS: Children with OO (N = 20) were offered 10 sessions of EEG neurofeedback over 6 weeks. Assessments prior and after the end of treatment included interview-based, self- and parent-report measures as well as objective anthropometrics. RESULTS: EEG neurofeedback resulted in a less than small-sized reduction of food-specific high beta band activity pre- vs. post-intervention. Small effects on the reduction of children's standardized body mass index, external eating behavior, and medium to large effects for overeating were documented. Feasibility and acceptance were provided. CONCLUSION: Promising results of the present proof-of-concept study indicate the need for further in-depth research with larger samples, adequate control groups, and randomized design. SIGNIFICANCE: Potentially, EEG neurofeedback is a valuable, resource-efficient addition to standard treatment options for childhood obesity. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Hahn, Ulrike AU - Hahn U AD - University of Leipzig Medical Center, Integrated Research and Treatment Center AdiposityDiseases, Behavioral Medicine Research Unit, Department of Psychosomatic Medicine and Psychotherapy, Philipp-Rosenthal-Strasse 55, D-04103 Leipzig, Germany. Electronic address: ulrikeh@posteo.de. FAU - Hubner, Claudia AU - Hubner C AD - University of Leipzig Medical Center, Integrated Research and Treatment Center AdiposityDiseases, Behavioral Medicine Research Unit, Department of Psychosomatic Medicine and Psychotherapy, Philipp-Rosenthal-Strasse 55, D-04103 Leipzig, Germany. FAU - Hilbert, Anja AU - Hilbert A AD - University of Leipzig Medical Center, Integrated Research and Treatment Center AdiposityDiseases, Behavioral Medicine Research Unit, Department of Psychosomatic Medicine and Psychotherapy, Philipp-Rosenthal-Strasse 55, D-04103 Leipzig, Germany; German Center for Child and Adolescent Health (DZKJ), partner site Leipzig/Dresden, Leipzig, Germany. FAU - Schmidt, Ricarda AU - Schmidt R AD - German Center for Child and Adolescent Health (DZKJ), partner site Leipzig/Dresden, Leipzig, Germany; Department of Child and Adolescent Psychiatry, Psychotherapy and Psychosomatics, University Hospital Leipzig, Leipzig, Germany. LA - eng PT - Journal Article DEP - 20260917 PL - Netherlands TA - Brain Res JT - Brain research JID - 0045503 SB - IM MH - Humans MH - *Neurofeedback/methods MH - Child MH - Male MH - Female MH - Electroencephalography/methods MH - Proof of Concept Study MH - Adolescent MH - *Overweight/therapy/physiopathology MH - Body Mass Index MH - *Pediatric Obesity/therapy/physiopathology MH - Brain/physiopathology MH - Beta Rhythm/physiology MH - Obesity MH - Feeding Behavior/physiology MH - Quality of Life MH - Treatment Outcome OTO - NOTNLM OT - Childhood obesity OT - EEG neurofeedback OT - Frequency bands OT - Intervention OT - Neuromodulation OT - Self-regulation COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/17 23:34 MHDA- 2026/10/29 05:30 CRDT- 2026/09/17 19:13 PHST- 2026/02/16 00:00 [received] PHST- 2026/09/16 00:00 [revised] PHST- 2026/09/17 00:00 [accepted] PHST- 2026/10/29 05:30 [medline] PHST- 2026/09/17 23:34 [pubmed] PHST- 2026/09/17 19:13 [entrez] AID - S0006-8993(26)00416-6 [pii] AID - 10.1016/j.brainres.2026.150554 [doi] PST - ppublish SO - Brain Res. 2026 Dec 1;1892:150554. doi: 10.1016/j.brainres.2026.150554. Epub 2026 Sep 17. PMID- 42753269 OWN - NLM STAT- MEDLINE DCOM- 20261028 LR - 20261028 IS - 1715-5320 (Electronic) IS - 1715-5312 (Linking) VI - 51 DP - 2026 Jan 1 TI - Low energy availability and female athlete Triad risk in Black collegiate track and field athletes. PG - 1-9 LID - 10.1139/apnm-2026-0036 [doi] AB - This study evaluated energy availability, menstrual function, bone mineral density (BMD), and female athlete Triad (Triad) risk among Black collegiate female track and field athletes. Study participants were female athletes (n = 18) on the track and field team at a Historically Black College/University. Energy intake and expenditure were estimated using an 8-day doubly labeled water protocol. Body composition was measured using dual-energy X-ray absorptiometry. Energy availability (EA) was calculated as (energy intake - activity energy expenditure)/fat free mass (FFM). Triad risk was assessed using female athlete Triad cumulative risk assessment. Survey responses captured eating behaviors, menstrual history, and food security status. Among these athletes, 56% exhibited EA below 45 kcal/kgFFM/day, and 17% were classified with clinical low energy availability (LEA) (<30 kcal/kgFFM/day). Forty-four percent of athletes met criteria for moderate Triad risk, though none were at high risk and none met criteria for low BMD. EA was inversely associated with body mass index (BMI) (r = -0.48, p = 0.04). Athletes reporting disordered/binge eating had significantly lower EA (p = 0.02). Food insecurity was identified among 22% of the study population but was not significantly associated with LEA or Triad risk. Over half of the Black female collegiate track and field athletes exhibited LEA, with nearly half meeting criteria for moderate Triad risk despite normal BMD and BMI. These findings highlight the need for routine screening and tailored interventions addressing LEA, menstrual dysfunction, and disordered eating in underrepresented athlete populations. ClinicalTrials.gov Identifier: NCT07631312. FAU - Taylor, Altelisha L AU - Taylor A AD - Department of Family Medicine, Morehouse School of Medicine, Atlanta, GA, USA. FAU - Moore, Carla J AU - Moore C AD - Clinical Research Center, Morehouse School of Medicine, Atlanta, GA, USA. RINGGOLD: 1374 FAU - Barrack, Michelle T AU - Barrack M AUID- ORCID: 0000-0003-0897-1832 AD - Department of Family and Consumer Sciences, California State University, Long Beach, Long Beach, CA, USA. RINGGOLD: 14668 LA - eng SI - ClinicalTrials.gov/NCT07631312 PT - Journal Article PL - Canada TA - Appl Physiol Nutr Metab JT - Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme JID - 101264333 SB - IM MH - Humans MH - Female MH - *Female Athlete Triad Syndrome/epidemiology/etiology MH - *Energy Intake MH - Bone Density MH - Energy Metabolism MH - *Athletes MH - Young Adult MH - *Track and Field MH - *Black or African American MH - Body Composition MH - Risk Factors MH - Adolescent MH - Body Mass Index MH - Relative Energy Deficiency in Sport MH - Absorptiometry, Photon MH - Historically Black Colleges and Universities OTO - NOTNLM OT - bone mineral density OT - energy deficiency OT - food insecurity OT - menstrual function COIS- The authors declare there are no competing interests. EDAT- 2026/09/17 23:34 MHDA- 2026/10/28 11:34 CRDT- 2026/09/17 17:42 PHST- 2026/10/28 11:34 [medline] PHST- 2026/09/17 23:34 [pubmed] PHST- 2026/09/17 17:42 [entrez] AID - 10.1139/apnm-2026-0036 [doi] PST - ppublish SO - Appl Physiol Nutr Metab. 2026 Jan 1;51:1-9. doi: 10.1139/apnm-2026-0036. PMID- 42753249 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20260925 IS - 2561-1011 (Electronic) IS - 2561-1011 (Linking) VI - 10 DP - 2026 Sep 17 TI - Improving Cardiometabolic Health in Adolescent Girls With Elevated Anxiety: Web-Based Multisite, Pilot, and Feasibility Randomized Controlled Trial. PG - e82781 LID - 10.2196/82781 [doi] LID - e82781 AB - BACKGROUND: Anxiety is common in adolescents with elevated BMI (kg/m(2)), affecting 33%-43% of adolescents with overweight or obesity (age- and sex-specific BMI >/=85th percentile ). Anxiety has been associated with poorer cardiometabolic health, and disinhibited eating in response to anxiety may be a key explanatory mechanism. Therefore, reducing anxiety in adolescents may improve disinhibited eating patterns and prevent worsening cardiometabolic health. OBJECTIVE: This pilot study primarily aimed to assess the feasibility and acceptability of 2 virtual group psychological interventions, interpersonal psychotherapy (IPT) and cognitive behavioral therapy (CBT), in adolescent girls with elevated anxiety and above-average weight. Secondary aims were to describe changes in anxiety, eating behavior, and cardiometabolic health indices. METHODS: This 2-site, 2-year, pilot and feasibility randomized controlled trial enrolled 12- to 17-year-old girls with elevated anxiety symptoms (State-Trait Anxiety Inventory for Children total score >/=32) and above-average weight (BMI >/=75th percentile for age and sex), who were in good general health and not concurrently receiving therapy or medication treatment. Girls were randomly assigned to 1 of 2 web-based arms: 12-week, psychologist-led, group IPT or CBT. In both arms, groups of 5-7 adolescents met for 90 minutes on secure Zoom (Zoom Communications, Inc) once per week. Anxiety, disinhibited eating, BMI indices, blood pressure, lipids, hemoglobin A(1c) (HbA(1c)), and fasting glucose were measured at baseline, 12-week follow-up, and 1-year follow-up. Feasibility of recruitment, retention, and study protocol, and acceptability and fidelity of IPT and CBT were evaluated. RESULTS: Of 47 eligible adolescents, 40 (85%) enrolled. Enrollment of the total sample (n=40) was completed in 7 months. Retention was 85% (n=17) in IPT and 100% (n=20) in CBT at 12-week follow-up. Protocol adherence exceeded 96% for all intervals. Missing data varied, with higher rates for phlebotomy (up to 30%). Acceptability ratings were above-average for likability (mean 3.03, SD 1.14) and credibility (mean 3.26, SD 0.75; 0-4 scale with 4=Highest) across arms. Most adolescents received >/=80% intervention dosage (IPT: 90%, CBT: 95%). Expert fidelity ratings of IPT were 78% (SD 11%) and CBT were 94% (SD 9%). From baseline to 1-year, IPT demonstrated improvements in general anxiety (95% CI -8.95 to -1.40), social anxiety (95% CI -12.37 to -1.88), and HbA(1c) (95% CI -0.48 to -0.23); CBT demonstrated improvement in emotional eating (95% CI -1.18 to -0.18), and both arms demonstrated improvements in BMI percentile (effect sizes=-0.82 and -0.63, IPT and CBT, respectively). CONCLUSIONS: This pilot and feasibility trial provided initial support for the feasibility of recruitment and retention and acceptability of web-based group IPT and CBT, as well as yielded areas for optimizing protocol feasibility and intervention fidelity. These preliminary results inform the planning of larger-scale efficacy trials with powered samples to assess effects on BMI and cardiometabolic health indicators among adolescents with elevated anxiety and above-average weight. CI - (c) Caitlin Edwards, LIsa Ranzenhofer, Jason Lavender, Lauren D Gulley, Stephen Aichele, Isabel Thorstad, Natalia Sanchez, Ruby Schrag, Zoe Sinkford, Jill Emerick, Victoria Thomas, Thomas Arnold, Jami Young, Denise Wilfley, Mark Haigney, Lauren Shomaker, Marian Tanofsky-Kraff. Originally published in JMIR Cardio (https://cardio.jmir.org). FAU - Edwards, Caitlin AU - Edwards C AUID- ORCID: 0000-0001-7576-0483 AD - Department of Human Development and Family Studies, College of Health and Human Services, Colorado State University, 410 W. Pitkin St, 1570 Campus Delivery, Fort Collins, CO, 80523, United States, 1 970-491-3217. AD - Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO, United States. FAU - Ranzenhofer, Lisa AU - Ranzenhofer L AUID- ORCID: 0000-0002-7199-6998 AD - Department of Psychiatry, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, Buffalo, NY, United States. FAU - Lavender, Jason AU - Lavender J AUID- ORCID: 0000-0001-9853-2280 AD - Department of Medicine, Military and Cardiovascular Outcomes Research (MiCOR), Uniformed Services University of the Health Sciences, Bethesda, MD, United States. AD - The Metis Foundation, San Antonio, TX, United States. FAU - Gulley, Lauren D AU - Gulley LD AUID- ORCID: 0000-0002-3868-8096 AD - Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO, United States. AD - University of Colorado Anschutz Medical Campus, 6Barbara Davis Center for Diabetes, Aurora, CO, United States. FAU - Aichele, Stephen AU - Aichele S AUID- ORCID: 0000-0002-3397-7921 AD - Department of Human Development and Family Studies, College of Health and Human Services, Colorado State University, 410 W. Pitkin St, 1570 Campus Delivery, Fort Collins, CO, 80523, United States, 1 970-491-3217. FAU - Thorstad, Isabel AU - Thorstad I AUID- ORCID: 0009-0005-7710-0186 AD - Department of Medicine, Military and Cardiovascular Outcomes Research (MiCOR), Uniformed Services University of the Health Sciences, Bethesda, MD, United States. FAU - Sanchez, Natalia AU - Sanchez N AUID- ORCID: 0000-0001-7929-4029 AD - Department of Human Development and Family Studies, College of Health and Human Services, Colorado State University, 410 W. Pitkin St, 1570 Campus Delivery, Fort Collins, CO, 80523, United States, 1 970-491-3217. FAU - Schrag, Ruby AU - Schrag R AUID- ORCID: 0009-0001-5691-4659 AD - Department of Medicine, Military and Cardiovascular Outcomes Research (MiCOR), Uniformed Services University of the Health Sciences, Bethesda, MD, United States. FAU - Sinkford, Zoe AU - Sinkford Z AUID- ORCID: 0009-0008-4359-4271 AD - Department of Medicine, Military and Cardiovascular Outcomes Research (MiCOR), Uniformed Services University of the Health Sciences, Bethesda, MD, United States. FAU - Emerick, Jill AU - Emerick J AUID- ORCID: 0000-0002-1839-8980 AD - Department of Pediatrics, Uniformed Services University, Bethesda, MD, United States. FAU - Thomas, Victoria AU - Thomas V AUID- ORCID: 0009-0003-6480-9394 AD - Department of Medicine, Military and Cardiovascular Outcomes Research (MiCOR), Uniformed Services University of the Health Sciences, Bethesda, MD, United States. FAU - Arnold, Thomas AU - Arnold T AUID- ORCID: 0009-0003-9665-4518 AD - Department of Medicine, Military and Cardiovascular Outcomes Research (MiCOR), Uniformed Services University of the Health Sciences, Bethesda, MD, United States. FAU - Young, Jami AU - Young J AUID- ORCID: 0000-0002-7488-5097 AD - Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, United States. FAU - Wilfley, Denise AU - Wilfley D AUID- ORCID: 0000-0002-3599-8689 AD - Department of Psychiatry, Washington University in St. Louis, St. Louis, MO, United States. FAU - Haigney, Mark AU - Haigney M AUID- ORCID: 0000-0001-6449-4386 AD - Department of Medicine, Military and Cardiovascular Outcomes Research (MiCOR), Uniformed Services University of the Health Sciences, Bethesda, MD, United States. FAU - Shomaker, Lauren AU - Shomaker L AUID- ORCID: 0000-0002-6129-8707 AD - Department of Human Development and Family Studies, College of Health and Human Services, Colorado State University, 410 W. Pitkin St, 1570 Campus Delivery, Fort Collins, CO, 80523, United States, 1 970-491-3217. AD - Endocrinology, Department of Pediatrics, University of Colorado Anschutz Medical Campus and Children's Hospital Colorado, Aurora, CO, United States. FAU - Tanofsky-Kraff, Marian AU - Tanofsky-Kraff M AUID- ORCID: 0000-0003-3871-2233 AD - Department of Medicine, Military and Cardiovascular Outcomes Research (MiCOR), Uniformed Services University of the Health Sciences, Bethesda, MD, United States. AD - Department of Medical and Clinical Psychology, Uniformed Services University, Bethesda, MD, United States. LA - eng PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20260917 PL - Canada TA - JMIR Cardio JT - JMIR cardio JID - 101718325 SB - IM MH - Humans MH - Female MH - Adolescent MH - Pilot Projects MH - Feasibility Studies MH - *Anxiety/therapy/psychology MH - *Cognitive Behavioral Therapy/methods MH - Child MH - Body Mass Index PMC - PMC13585365 OTO - NOTNLM OT - adolescents OT - anxiety OT - cardiometabolic health OT - cognitive behavioral therapy OT - eating behaviors OT - feasibility OT - interpersonal psychotherapy OT - pilot trial COIS- Conflicts of Interest: None declared. EDAT- 2026/09/17 18:32 MHDA- 2026/09/17 18:33 PMCR- 2026/09/17 CRDT- 2026/09/17 16:29 PHST- 2025/08/21 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/17 18:33 [medline] PHST- 2026/09/17 18:32 [pubmed] PHST- 2026/09/17 16:29 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - v10i1e82781 [pii] AID - 82781 [pii] AID - 10.2196/82781 [doi] PST - epublish SO - JMIR Cardio. 2026 Sep 17;10:e82781. doi: 10.2196/82781. PMID- 42752631 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20260922 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 9 DP - 2026 TI - Machine learning and deep learning-based prediction of hypertension and analysis of its major risk factors in Bangladesh. PG - e0358471 LID - 10.1371/journal.pone.0358471 [doi] LID - e0358471 AB - BACKGROUND: Hypertension is a leading cause of cardiovascular morbidity and mortality in Bangladesh. This study examined its prevalence, risk factors, and predictive modeling using machine learning (ML) and deep learning (DL) approaches. METHOD: We analyzed cross-sectional data from the 2022 Bangladesh Demographic and Health Survey, which included 14,283 adults (>/=18 years). Prevalence was estimated, chi-square tests assessed associations, and four ML models (weighted logistic regression, random forest, extreme gradient boosting, light gradient boosting machine) and two DL models (TabNet, and multi-layer perceptron) were applied to predict hypertension risk. Model performance was evaluated using accuracy, precision, recall, specificity, F1 score, and area under the receiver operating characteristics curve and precision-recall curve. RESULTS: Overall prevalence was 18.04% (95% CI: 17.2%-18.9%), higher among women (18.87%) than men (16.97%). The chi-square test suggests that hypertension was significantly associated with age, BMI, diabetes, wealth index, education, household size, and region (p < 0.05). Among the machine learning and deep learning models, weighted logistic regression (WLR) achieved the highest accuracy (0.817), precision (0.444), specificity (0.981), AUC-ROC (0.751), and AUC-PR (0.357). However, WLR exhibited low recall (0.070). In contrast, the random forest (RF) model achieved the highest recall (0.687) and F1-score (0.460) on the test data, indicating greater sensitivity in identifying individuals with hypertension. Additionally, age, BMI, sex, family size, and educational level were identified as the most important predictors among the variables included in the study. CONCLUSION: Hypertension is common in Bangladesh, with higher prevalence in women and significant association with socio-demographic determinants. Although WLR demonstrated the highest accuracy, precision, specificity, and AUC-PR, its low recall limits its utility for identifying individuals with hypertension. RF may be more suitable for public health applications because of its higher recall and F1-score; however, further external validation and assessment of its clinical utility are required before implementation. CI - Copyright: (c) 2026 Chandra et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Chandra, Shawrab AU - Chandra S AD - Department of Statistics and Data Science, University of Barishal, Barishal, Bangladesh. FAU - Molla, Md Maeen AU - Molla MM AUID- ORCID: 0009-0000-9315-7338 AD - Department of Statistics, Pirojpur Science and Technology University, Pirojpur, Bangladesh. FAU - Islam, Samiul AU - Islam S AD - Department of Statistics and Data Science, University of Rajshahi, Rajshahi, Bangladesh. FAU - Rahaman, Md Matiur AU - Rahaman MM AUID- ORCID: 0000-0001-9799-9364 AD - Department of Statistics, Faculty of Science, Gopalganj Science and Technology University, Gopalganj, Bangladesh. FAU - Ali, Mohammad AU - Ali M AUID- ORCID: 0000-0002-0279-1972 AD - Statistics Discipline, Khulna University, Khulna, Bangladesh. FAU - Ali, Md Ayub AU - Ali MA AUID- ORCID: 0000-0002-5113-0054 AD - Department of Statistics and Data Science, University of Barishal, Barishal, Bangladesh. LA - eng PT - Journal Article DEP - 20260917 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - *Hypertension/epidemiology/diagnosis MH - Humans MH - Female MH - *Deep Learning MH - Bangladesh/epidemiology MH - Risk Factors MH - Male MH - Adult MH - Predictive Learning Models MH - Middle Aged MH - Random Forest MH - Cross-Sectional Studies MH - Prevalence MH - Boosting Machine Learning Algorithms MH - *Machine Learning MH - Prediction Algorithms MH - Young Adult MH - Adolescent MH - Classification Algorithms MH - Logistic Models MH - ROC Curve PMC - PMC13585235 COIS- The authors have declared that no competing interests exist. EDAT- 2026/09/17 18:32 MHDA- 2026/09/17 18:33 PMCR- 2026/09/17 CRDT- 2026/09/17 15:52 PHST- 2025/10/16 00:00 [received] PHST- 2026/09/01 00:00 [accepted] PHST- 2026/09/17 18:33 [medline] PHST- 2026/09/17 18:32 [pubmed] PHST- 2026/09/17 15:52 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - PONE-D-25-55897 [pii] AID - 10.1371/journal.pone.0358471 [doi] PST - epublish SO - PLoS One. 2026 Sep 17;21(9):e0358471. doi: 10.1371/journal.pone.0358471. eCollection 2026. PMID- 42752205 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261024 IS - 2165-0497 (Electronic) IS - 2165-0497 (Linking) VI - 14 IP - 10 DP - 2026 Oct 6 TI - Multi-omics insights into growth impairment mechanisms in children with persistent diarrhea. PG - e0390525 LID - 10.1128/spectrum.03905-25 [doi] LID - e03905-25 AB - This study aimed to elucidate the key mechanisms underlying short stature with pediatric persistent diarrhea in children (PDC) and to propose an integrated model linking the butyrate-producing gut microbial niche, short-chain fatty acids (SCFAs), Th17/Treg balance, the growth hormone-insulin-like growth factor 1 (GH-IGF-1) axis, and growth regulation. Samples from healthy controls (HCs), PDC patients without short stature (PDC-NS), and PDC patients with short stature (PDC-S) were analyzed using multi-omics profiling and machine learning-based predictive modeling. The results showed that PDC-S patients exhibited disruption of core butyrate-producing bacterial communities and related metabolic pathways, markedly reduced fecal butyrate levels, systemic Th17/Treg imbalance characterized by a pro-inflammatory state, and dual suppression of receptor- and ligand-level components of the GH-IGF-1 axis. Multi-omics machine learning identified a five-factor risk prediction panel composed of metabolic, immune, and endocrine markers, while causal inference further established butyrate as a central regulator of growth. Mouse experiments further validated that combined intervention with butyrate, Faecalibacterium prausnitzii, and recombinant human growth hormone (rhGH) ameliorated growth retardation. Overall, this study proposes a precision therapeutic strategy based on butyrate and GH co-intervention, providing new mechanistic insights and translational tools for PDC-associated short stature. IMPORTANCE: The research conducted in this study holds significant implications for improving the understanding and treatment of stunted growth with persistent diarrhea in children (PDC). By unraveling the intricate pathways linking gut microbiota, immune responses, and growth hormone regulation, the study sheds light on the underlying mechanisms contributing to stunting in these vulnerable populations. The identification of key factors, such as butyrate-producing bacteria and the Th17/Treg balance, not only enhances our comprehension of PDC-related growth impairment but also offers a promising avenue for targeted interventions. The proposed integrated mechanistic model and intervention strategy pave the way for precision therapies tailored to address the specific biological mechanisms at play, potentially leading to more effective and personalized treatments for children suffering from PDC-associated stunting. FAU - Shen, Jian AU - Shen J AUID- ORCID: 0000-0001-9332-5389 AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Yan, Junle AU - Yan J AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Yuan, Ying AU - Yuan Y AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Le, Lilin AU - Le L AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Xu, Juan AU - Xu J AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Chen, Bailu AU - Chen B AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Liu, Xiaoying AU - Liu X AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Chen, Huijie AU - Chen H AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Chen, Lijun AU - Chen L AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Yi, Meixiang AU - Yi M AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Lyu, Jiajia AU - Lyu J AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Diao, Jun AU - Diao J AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Zhang, Xinlin AU - Zhang X AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Zhao, Yinqiu AU - Zhao Y AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 FAU - Chen, Jingru AU - Chen J AD - Department of Pediatrics, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. RINGGOLD: 66322. ROR: https://ror.org/00z27jk27 LA - eng GR - E4-H200210199/Shanghai University of Traditional Chinese Medicine General Program/ GR - ZY(2021-2023)-0206-03/Shanghai Municipal Health Commission Three-Year Action Plan for TCM Development/ PT - Journal Article DEP - 20260917 PL - United States TA - Microbiol Spectr JT - Microbiology spectrum JID - 101634614 RN - 0 (Fatty Acids, Volatile) RN - 0 (Butyrates) RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 12629-01-5 (Human Growth Hormone) RN - 9002-72-6 (Growth Hormone) SB - IM MH - Humans MH - *Diarrhea/microbiology/complications/metabolism MH - Animals MH - Multiomics MH - Child MH - Fatty Acids, Volatile/metabolism MH - Butyrates/metabolism MH - *Growth Disorders/microbiology/metabolism MH - Insulin-Like Growth Factor I/metabolism MH - Male MH - Mice MH - Female MH - Feces/microbiology/chemistry MH - Gastrointestinal Microbiome MH - Child, Preschool MH - T-Lymphocytes, Regulatory/immunology MH - Human Growth Hormone/metabolism MH - Th17 Cells/immunology MH - Faecalibacterium prausnitzii/physiology MH - Machine Learning MH - Growth Hormone MH - Bacteria/classification/genetics/isolation & purification/metabolism PMC - PMC13689471 OTO - NOTNLM OT - T helper 17 cells/regulatory T-cell balance OT - butyrate OT - growth hormone-insulin-like growth factor 1 axis OT - machine learning OT - multi-omics OT - persistent diarrhea in children OT - short-chain fatty acids OT - stunting COIS- The authors declare no conflict of interest. EDAT- 2026/09/17 18:33 MHDA- 2026/10/07 05:31 PMCR- 2026/09/17 CRDT- 2026/09/17 15:30 PHST- 2026/10/07 05:31 [medline] PHST- 2026/09/17 18:33 [pubmed] PHST- 2026/09/17 15:30 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - spectrum03905-25 [pii] AID - spectrum.03905-25 [pii] AID - 10.1128/spectrum.03905-25 [doi] PST - ppublish SO - Microbiol Spectr. 2026 Oct 6;14(10):e0390525. doi: 10.1128/spectrum.03905-25. Epub 2026 Sep 17. PMID- 42751864 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20260923 IS - 1365-2060 (Electronic) IS - 0785-3890 (Print) IS - 0785-3890 (Linking) VI - 58 IP - 1 DP - 2026 Dec TI - Association of body mass index with postoperative pulmonary complications and potential explanatory pathways in paediatric scoliosis correction surgery: a multicentre cohort study. PG - 2731716 LID - 10.1080/07853890.2026.2731716 [doi] LID - 2731716 AB - BACKGROUND: Postoperative pulmonary complications (PPCs) contribute substantially to morbidity after paediatric scoliosis correction surgery, but the relationship between preoperative body mass index (BMI) and PPCs remains uncertain. We evaluated this association and explored potential explanatory pathways and the incremental predictive value of BMI. METHODS: This retrospective cohort study included 1,165 patients from three Chinese tertiary hospitals. Associations between BMI and the composite PPC outcome were evaluated using multivariable regression. An orthogonalized causal forest estimated the average partial effect of continuous BMI on PPC probability, and variation in model-derived partial-effect predictions across sex and preoperative Cobb-angle strata was examined descriptively. Exploratory pathway analyses considered the Prognostic Nutritional Index (PNI), intraoperative blood loss, and fusion levels. At the completion of surgery, the incremental predictive value of BMI was assessed using an elastic-net model developed in centres 1 and 3 and externally validated in centre 2. RESULTS: PPCs occurred in 321 patients (27.55%). In the primary preoperative-adjusted model, each 1-kg/m(2) higher BMI was associated with lower odds of PPCs (aOR, 0.87; 95% CI, 0.83-0.91; p < 0.001). A secondary exploratory perioperative-adjusted model yielded a similar estimate (aOR, 0.85; 95% CI, 0.81-0.89; p < 0.001). Compared with normal weight, thinness was associated with higher odds of PPCs (aOR, 4.26; 95% CI, 2.74-6.67; p < 0.001), whereas overweight was associated with lower odds (aOR, 0.57; 95% CI, 0.34-0.91; p = 0.022). The causal forest yielded an inverse average partial-effect estimate for BMI (-0.031; 95% CI, -0.037 to -0.025; p < 0.001). Exploratory pathway analyses suggested small indirect components through PNI, blood loss, and fusion levels. Adding BMI increased the external-validation AUC from 0.658 to 0.703 (p < 0.001), representing a modest improvement in discrimination. CONCLUSIONS: Higher preoperative BMI was associated with lower odds of PPCs, with a concordant inverse causal-forest estimate under its identification assumptions. Low BMI or thinness may serve as a preoperative risk marker, while the examined pathways accounted for only small proportions of the association. At the end-of-surgery prediction time point, adding BMI provided modest incremental predictive value, although the model's external performance was modest and further prospective validation is required. FAU - Shi, Weihai AU - Shi W AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. AD - Medical School of Nanjing University, Nanjing, China. FAU - Zhu, Shouqiang AU - Zhu S AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. AD - Medical School of Nanjing University, Nanjing, China. FAU - Wang, Yan AU - Wang Y AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. AD - Drum Tower Clinical Medical School, Nanjing Medical University, Nanjing, China. FAU - Sun, Yanhua AU - Sun Y AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. FAU - Zheng, Zhiying AU - Zheng Z AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. AD - Medical School of Nanjing University, Nanjing, China. FAU - Liu, Peiyu AU - Liu P AD - Department of Operating Room, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. FAU - Zhang, Ruocui AU - Zhang R AD - Post-Anesthesia Care Unit, Department of Anesthesiology and Surgery, Nanjing Drum Tower Hospital, Nanjing, China. FAU - Xia, Tianjiao AU - Xia T AD - Medical School of Nanjing University, Nanjing, China. FAU - Ma, Lulu AU - Ma L AD - Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China. FAU - Li, Min AU - Li M AUID- ORCID: 0000-0003-4853-4258 AD - Department of Anesthesiology, Peking University Third Hospital, Beijing, China. FAU - Bo, Jinhua AU - Bo J AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. FAU - Gu, Xiaoping AU - Gu X AD - Department of Anesthesiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China. AD - Medical School of Nanjing University, Nanjing, China. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260917 PL - England TA - Ann Med JT - Annals of medicine JID - 8906388 SB - IM MH - Humans MH - *Scoliosis/surgery MH - Female MH - *Body Mass Index MH - Retrospective Studies MH - *Postoperative Complications/epidemiology/etiology MH - Male MH - Child MH - *Lung Diseases/etiology/epidemiology MH - Adolescent MH - China/epidemiology MH - Spinal Fusion/adverse effects MH - Risk Factors MH - Blood Loss, Surgical/statistics & numerical data PMC - PMC13587573 OTO - NOTNLM OT - Body mass index OT - paediatric scoliosis OT - postoperative pulmonary complications OT - scoliosis surgery COIS- No potential conflict of interest was reported by the authors. EDAT- 2026/09/17 15:37 MHDA- 2026/09/17 15:38 PMCR- 2026/09/17 CRDT- 2026/09/17 07:27 PHST- 2026/09/17 15:38 [medline] PHST- 2026/09/17 15:37 [pubmed] PHST- 2026/09/17 07:27 [entrez] PHST- 2026/09/17 00:00 [pmc-release] AID - 2731716 [pii] AID - 10.1080/07853890.2026.2731716 [doi] PST - ppublish SO - Ann Med. 2026 Dec;58(1):2731716. doi: 10.1080/07853890.2026.2731716. Epub 2026 Sep 17. PMID- 42751489 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260917 LR - 20260918 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Explainable machine learning for age-specific talent identification in Chinese youth football. PG - 1912796 LID - 10.3389/fspor.2026.1912796 [doi] LID - 1912796 AB - BACKGROUND AND AIMS: To identify elite youth football players in China, we developed an interpretable machine learning model. METHODS: We modeled each age group separately to track changes in predictive factors across different age groups. A cross-sectional analysis included 398 players from the 2024 Yunnan Football Association Elite Training Camp (U8 to U12). All participants underwent a multidimensional assessment covering anthropometric, physical, technical, psychological, and match performance dimensions. In our prediction model, coaches' selection of provincial elite players was used as the outcome variable. Three classifiers: XGBoost, Random Forest, and Logistic Regression, were trained with hyperparameter tuning and 5-fold cross-validation. Then we used SHapley Additive exPlanations (SHAP) to interpret our models. RESULTS: The best-performing model demonstrated high discriminative ability (test set ROC-AUC: 0.900-0.957). SHAP analysis indicated that dribbling speed and standing long jump consistently mattered at all ages, while sprint performance were especially important for the U8 and U10 groups. Notably, for U12 males, left-foot shooting skill was the strongest predictor, while for U12 females, tactical awareness during matches emerged as most important. Psychological traits contributed little predictive value. When we applied retrospectively to national selection data, the U12M model showed fair agreement (K = 0.269) but identified 40%-47% of national elites and highlighted several overlooked high-potential players. CI - (c) 2026 Tong, Bi, Li, Chen, Liu and Chen. FAU - Tong, Yan AU - Tong Y AD - School of Physical Education, Yunnan University, Kunming, China. FAU - Bi, Jingyi AU - Bi J AD - School of Life Sciences, Yunnan University, Kunming, China. FAU - Li, Shixin AU - Li S AD - Kunming Institute of Zoology, University of Chinese Academy of Sciences, Beijing, China. FAU - Chen, Luohang AU - Chen L AD - School of Physical Education, Yunnan University, Kunming, China. FAU - Liu, Chun AU - Liu C AD - School of Physical Education, Yunnan University, Kunming, China. FAU - Chen, Hengxin AU - Chen H AD - School of Physical Education, Yunnan University, Kunming, China. LA - eng PT - Journal Article DEP - 20260902 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13579789 OTO - NOTNLM OT - Chinese athletes OT - explainable machine learning OT - predictive modeling OT - talent identification OT - youth football COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/17 15:39 MHDA- 2026/09/17 15:40 PMCR- 2026/09/02 CRDT- 2026/09/17 06:59 PHST- 2026/06/18 00:00 [received] PHST- 2026/07/29 00:00 [revised] PHST- 2026/07/31 00:00 [accepted] PHST- 2026/09/17 15:40 [medline] PHST- 2026/09/17 15:39 [pubmed] PHST- 2026/09/17 06:59 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - 10.3389/fspor.2026.1912796 [doi] PST - epublish SO - Front Sports Act Living. 2026 Sep 2;8:1912796. doi: 10.3389/fspor.2026.1912796. eCollection 2026. PMID- 42751182 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20260918 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Childhood asthma and the microbiome: from gut-lung axis mechanisms to precision prevention strategies. PG - 1902053 LID - 10.3389/fimmu.2026.1902053 [doi] LID - 1902053 AB - Childhood asthma is a highly heterogeneous chronic respiratory disease, and its onset and progression are intricately linked to genetic susceptibility, environmental exposure, immune development, and the establishment of the early-life microbiome. In recent years, studies on the gut and respiratory microbiomes have suggested that the composition, metabolic functions, and interactions of microbial communities with the host immune system may be involved in the formation of asthma susceptibility, shaping of inflammatory phenotypes, and disease progression in children. The gut-lung axis, as an important pathway connecting gut microbiome, respiratory immunity, and systemic inflammatory responses, provides a new perspective for understanding the early mechanisms of childhood asthma. This article reviews the characteristics of the respiratory and gut microbiomes associated with childhood asthma, with a focus on the roles of the gut-lung axis, microbial metabolites, mucosal immune regulation, and environmental exposure. It also evaluates the research progress of probiotics, prebiotics, nutritional interventions, and novel microecological therapies. Additionally, the potential of microbial maturity, microbial metabolites, and immunophenotypes as biomarkers for risk prediction, phenotype stratification, and treatment response is analyzed. Furthermore, the role of multi-omics integration in supporting the identification of responsive populations, matching of intervention strategies, and dynamic monitoring of efficacy is discussed. Current evidence suggests that the microbiome offers promising targets for risk assessment and precision prevention of childhood asthma. However, relevant research still faces challenges such as ambiguous causality, high cohort heterogeneity, limited reproducibility of candidate biomarkers, inconsistent intervention outcomes, and insufficient evidence of long-term safety. At present, most biomarkers and multi-omics models remain in the stage of association discovery, lacking unified thresholds, cross-cohort validation, and biomarker-guided randomized controlled trials in children. Therefore, they cannot be routinely used for patient stratification or intervention selection. Future efforts should rely on standardized longitudinal birth cohorts, multi-omics integration, external validation, and high-quality clinical trials to clarify the incremental value of microbiome biomarkers over traditional clinical indicators and their clinical utility in the individualized management of childhood asthma. CI - Copyright (c) 2026 Liang, Chen, Hu, Guo, Yang, Guo and Zhang. FAU - Liang, Xuan AU - Liang X AD - Department of Allergy, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, China. FAU - Chen, De AU - Chen D AD - Emergency Medical Center, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, China. FAU - Hu, Jiafen AU - Hu J AD - Department of Allergy, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, China. FAU - Guo, Li AU - Guo L AD - Department of Allergy, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, China. FAU - Yang, Hui AU - Yang H AD - Department of Allergy, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, China. FAU - Guo, Qi AU - Guo Q AD - Department of Allergy, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, China. FAU - Zhang, Rongfang AU - Zhang R AD - Department of Allergy, Gansu Provincial Maternity and Child Care Hospital, Lanzhou, Gansu, China. LA - eng PT - Journal Article PT - Review DEP - 20260902 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Asthma/prevention & control/microbiology/immunology/etiology MH - *Gastrointestinal Microbiome/immunology MH - Child MH - *Lung/immunology/microbiology MH - Animals MH - Precision Medicine MH - *Microbiota MH - Biomarkers MH - Probiotics/therapeutic use MH - Environmental Exposure/adverse effects MH - Disease Susceptibility PMC - PMC13580037 OTO - NOTNLM OT - childhood asthma OT - gut microbiome OT - gut-lung axis OT - microbiome OT - precision prevention OT - respiratory microbiome COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/17 15:39 MHDA- 2026/09/17 15:40 PMCR- 2026/09/02 CRDT- 2026/09/17 06:13 PHST- 2026/06/06 00:00 [received] PHST- 2026/08/08 00:00 [revised] PHST- 2026/08/12 00:00 [accepted] PHST- 2026/09/17 15:40 [medline] PHST- 2026/09/17 15:39 [pubmed] PHST- 2026/09/17 06:13 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1902053 [doi] PST - epublish SO - Front Immunol. 2026 Sep 2;17:1902053. doi: 10.3389/fimmu.2026.1902053. eCollection 2026. PMID- 42751027 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260917 LR - 20260919 IS - 2220-3230 (Print) IS - 2220-3230 (Electronic) IS - 2220-3230 (Linking) VI - 16 IP - 3 DP - 2026 Sep 18 TI - Growth and development following paediatric kidney transplantation: Mechanisms, influencing factors, and clinical management. PG - 120986 LID - 10.5500/wjt.120986 [doi] LID - 120986 AB - Paediatric kidney transplantation substantially improves survival and quality of life in children with end-stage kidney disease. However, impaired linear growth and broader developmental challenges remain common after transplantation. This article provides an evidence-based narrative review of the mechanisms, clinical determinants, monitoring strategies, and management options for post-transplant growth and development in paediatric kidney recipients, with particular emphasis on the growth hormone (GH)-insulin-like growth factor 1 axis, graft function, immunosuppression, nutrition, GH therapy, and long-term follow-up. Current evidence indicates that post-transplant growth is influenced by age at transplantation, pretransplant growth status, graft function, cumulative corticosteroid exposure, nutritional and metabolic status, and the selective use of recombinant human GH. Younger age at transplantation and steroid-sparing strategies are consistently associated with better height outcomes, whereas chronic graft dysfunction, persistent inflammation, and metabolic complications may attenuate catch-up growth. Emerging biomarkers and precision-medicine tools are promising, but most remain insufficiently validated for routine growth-focused decision-making. Optimising growth after paediatric kidney transplantation requires early transplantation when feasible, preservation of graft function, careful balancing of rejection prevention against growth toxicity, multidisciplinary nutritional and endocrine support, and structured long-term follow-up. The evidence base is expanding, but high-quality multicentre longitudinal studies are still needed. CI - (c)Author(s) 2026. FAU - Wang, Yu-Yang AU - Wang YY AD - Tongliao Clinical Medical College, Inner Mongolia Medical University, Tongliao 028000, Inner Mongolia Autonomous Region, China. FAU - Hang, Gai AU - Hang G AD - Department of Urinary Surgery, Tongliao City Hospital, Tongliao 028000, Inner Mongolia Autonomous Region, China. FAU - Wen, Quan AU - Wen Q AD - Department of Urinary Surgery, Tongliao City Hospital, Tongliao 028000, Inner Mongolia Autonomous Region, China. FAU - Guo, Yun-Peng AU - Guo YP AD - Tongliao Clinical Medical College, Inner Mongolia Medical University, Tongliao 028000, Inner Mongolia Autonomous Region, China. FAU - Long, Chen AU - Long C AD - Department of Surgery, Inner Mongolia Medical University, Tongliao 028000, Inner Mongolia Autonomous Region, China. FAU - Chen, Bo AU - Chen B AD - Department of Urinary Surgery, Tongliao People's Hospital, Tongliao 028000, Inner Mongolia Autonomous Region, China. chenmuxin@126.com. LA - eng PT - Journal Article PT - Review PL - United States TA - World J Transplant JT - World journal of transplantation JID - 101608356 PMC - PMC13579424 OTO - NOTNLM OT - Graft function OT - Growth and development OT - Growth hormone OT - Immunosuppression OT - Narrative review OT - Paediatric kidney transplantation COIS- Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article. EDAT- 2026/09/17 15:39 MHDA- 2026/09/17 15:40 PMCR- 2026/09/18 CRDT- 2026/09/17 05:40 PHST- 2026/03/13 00:00 [received] PHST- 2026/05/20 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/17 15:40 [medline] PHST- 2026/09/17 15:39 [pubmed] PHST- 2026/09/17 05:40 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.5500/wjt.120986 [doi] PST - ppublish SO - World J Transplant. 2026 Sep 18;16(3):120986. doi: 10.5500/wjt.120986. PMID- 42750879 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260917 LR - 20260918 IS - 2666-5352 (Electronic) IS - 2666-5352 (Linking) VI - 12 DP - 2026 Dec TI - Effectiveness of the digital parental-family-centered program for problematic gaming and screen use in a clinical child and adolescent population. PG - 100848 LID - 10.1016/j.puhip.2026.100848 [doi] LID - 100848 AB - OBJECTIVES: Problematic gaming and screen use may be associated with psychosocial, academic, and mental-health difficulties in children. The digital Parental-Family-Centered Program (P-FAME) is a brief, digitally delivered, parent-focused program developed in Child and Adolescent Mental Health Services. This study examined its feasibility and preliminary associations with change in child screen time, family functioning, and parental stress over time. STUDY DESIGN: Prospective single-group pre-post feasibility study. METHODS: Twenty-nine parents of 22 children (mean child age 10.6 years) participated in three online group sessions delivered over five weeks. Standardized measures were administered at baseline and post-intervention, including Screens-Q (screen time and rules), SCORE-15 (family functioning), and the Parental Stress Scale (PSS). Linear mixed-effects models accounting for clustering within families estimated change from pre-intervention to post-intervention. RESULTS: From baseline to post-intervention, children's weekly screen time decreased (adjusted mean difference: -1400 min/week, p < .001; d = -1.81), as did parental stress (p = .036; d = -0.63). The PSS stress subscale also decreased (p = .048, d = 0.59). No statistically significant changes were observed in overall family functioning or parental satisfaction. Child ADHD diagnosis and age did not significantly moderate the observed changes. CONCLUSIONS: In this uncontrolled clinical study, participation in P-FAME was associated with lower child screen time and parental stress. The findings provide preliminary feasibility and outcome signals that require confirmation in adequately powered controlled studies with longer follow-up and broader implementation measures. CI - (c) 2026 The Authors. FAU - Claesdotter-Knutsson, Emma AU - Claesdotter-Knutsson E AD - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. AD - Child and Adolescent Psychiatry, Regional Outpatient Care, Skane University Hospital, Lund, Region Skane, Sweden. FAU - Wilts, Sophie AU - Wilts S AD - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. AD - Child and Adolescent Psychiatry, Regional Outpatient Care, Skane University Hospital, Lund, Region Skane, Sweden. AD - Faculty of Medicine, University of Amsterdam, Amsterdam, the Netherlands. FAU - Werner, Marie AU - Werner M AD - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. AD - Child and Adolescent Psychiatry, Regional Outpatient Care, Skane University Hospital, Lund, Region Skane, Sweden. FAU - Andre, Frida AU - Andre F AD - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. AD - Primary Health Care, Region Dalarna, Sweden. FAU - Andersson, Mitchell J AU - Andersson MJ AD - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. AD - Child and Adolescent Psychiatry, Regional Outpatient Care, Skane University Hospital, Lund, Region Skane, Sweden. LA - eng PT - Journal Article DEP - 20260824 PL - England TA - Public Health Pract (Oxf) JT - Public health in practice (Oxford, England) JID - 101774776 PMC - PMC13579036 OTO - NOTNLM OT - Digital intervention OT - Family intervention OT - Problematic gaming OT - Problematic screen use COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/17 15:36 MHDA- 2026/09/17 15:37 PMCR- 2026/08/24 CRDT- 2026/09/17 05:13 PHST- 2026/04/16 00:00 [received] PHST- 2026/08/06 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/09/17 15:37 [medline] PHST- 2026/09/17 15:36 [pubmed] PHST- 2026/09/17 05:13 [entrez] PHST- 2026/08/24 00:00 [pmc-release] AID - S2666-5352(26)00127-8 [pii] AID - 100848 [pii] AID - 10.1016/j.puhip.2026.100848 [doi] PST - epublish SO - Public Health Pract (Oxf). 2026 Aug 24;12:100848. doi: 10.1016/j.puhip.2026.100848. eCollection 2026 Dec. PMID- 42750677 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20261002 LR - 20261002 IS - 2633-4402 (Electronic) IS - 2633-4402 (Linking) VI - 6 DP - 2026 TI - How to improve uptake and adherence to dietary trials in gestational diabetes amongst South Asian women: insights from patient and public involvement and engagement. PG - 77 LID - 10.3310/nihropenres.14303.3 [doi] LID - 77 AB - BACKGROUND: Gestational diabetes mellitus (GDM) is associated with adverse maternal and neonatal outcomes and affects approximately 10-20% of pregnancies in the UK. The prevalence of GDM among South Asian women is around twice that of White British women, and they are also twice as likely to develop type 2 diabetes following diagnosis. Although multiple dietary interventions have been explored to improve glycaemic control in GDM, no single dietary approach has proven consistently effective in improving health outcomes. METHODS: We conducted a patient and public involvement and engagement (PPIE) activity with South Asian women to inform a trial evaluating the acceptability, feasibility, and safety of an intermittent low-energy diet (ILED) in GDM. PPIE input was particularly valuable in addressing lower-than-anticipated recruitment and retention, especially among South Asian women, and provided insights into sociocultural barriers and facilitators to improve trial design and participation. CONCLUSIONS: Three priorities emerged as a potential means of enhancing engagement with South Asian women: addressing vulnerability (including trust and loss of control), improving accessibility, and reducing mental load (including competing priorities, emotional wellbeing, and family influence). These insights informed the trial design and recruitment strategies, building on existing literature which highlights the urgent need to address systemic racial biases and inequalities in healthcare and research. CI - Copyright: (c) 2026 Dapre E et al. FAU - Dapre, Elizabeth AU - Dapre E AUID- ORCID: 0000-0001-8220-4514 AD - Centre for Primary Care and Health Services Research, The University of Manchester Centre for Primary Care, Manchester, England, M13 9PL, UK. FAU - Harvie, Michelle AU - Harvie M AUID- ORCID: 0000-0001-9761-3089 AD - Department of Nutrition and Dietetics, Manchester University NHS Foundation Trust, Manchester, England, M13 9LW, UK. AD - Division of Cancer Sciences, The University of Manchester Division of Cancer Sciences, Manchester, England, M13 9NT, UK. FAU - Issa, Basil AU - Issa B AD - Diabetes, Endocrinology and Metabolic Services, Manchester University NHS Foundation Trust, Manchester, England, M13 9WL, UK. FAU - McMillan, Brian AU - McMillan B AUID- ORCID: 0000-0002-7635-8354 AD - Centre for Primary Care and Health Services Research, The University of Manchester Centre for Primary Care, Manchester, England, M13 9PL, UK. FAU - Morley, Helen AU - Morley H AUID- ORCID: 0000-0002-7635-8354 AD - Division of Psychology and Mental Health, The University of Manchester Division of Psychology and Mental Health, Manchester, England, M13 9PL, UK. LA - eng PT - Journal Article DEP - 20260929 PL - England TA - NIHR Open Res JT - NIHR open research JID - 9918333281906676 PMC - PMC13575402 OAB - South Asian women are twice as likely to develop gestational diabetes compared to White British women but remain underrepresented in clinical trials. Recruitment challenges in a recent intermittent diet trial prompted discussions with South Asian women to improve the inclusivity of the research design. Seventeen women ('contributors') from Greater Manchester, with personal or family experience of gestational diabetes, reviewed study materials and provided feedback on improving participation and trial design. Key barriers identified included lack of trust in researchers and perceived "research fatigue," where participants felt repeatedly asked to take part in research without seeing meaningful improvements in healthcare. Dietary adherence during pregnancy was also considered challenging due to cravings, household responsibilities, and caregiving roles. Contributors recommended family-based meal planning, pictorial guides for healthier alternatives, and financial support for childcare to facilitate attendance at trial appointments. Flexible face-to-face and online appointment options were positively received. Emotional wellbeing was also highlighted as a key factor influencing adherence, with suggestions for support groups to help participants manage stress and avoid using food for comfort. These discussions informed recommendations for more inclusive research design, which are shared to support future studies. OABL- eng OTO - NOTNLM OT - South Asian women OT - diet OT - gestational diabetes OT - patient and public involvement and engagement (PPIE) OT - trial design COIS- Competing interests: Michelle Harvie has coauthored three self-help books for the public to follow intermittent diets. All author proceeds are paid directly to the charity Prevent Breast Cancer (registered charity number 1109839) to fund breast cancer research. The other authors declare no conflicts of interest. EDAT- 2026/09/17 05:35 MHDA- 2026/09/17 05:36 PMCR- 2026/09/29 CRDT- 2026/09/17 04:39 PHST- 2026/09/24 00:00 [accepted] PHST- 2026/09/17 05:35 [pubmed] PHST- 2026/09/17 05:36 [medline] PHST- 2026/09/17 04:39 [entrez] PHST- 2026/09/29 00:00 [pmc-release] AID - 10.3310/nihropenres.14303.3 [doi] PST - epublish SO - NIHR Open Res. 2026 Sep 29;6:77. doi: 10.3310/nihropenres.14303.3. eCollection 2026. PMID- 42750024 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20260919 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Aug 26 TI - Pancreatic steatosis is associated with exocrine pancreatic dysfunction in children with MASLD: a prospective cross-sectional study. LID - 10.1186/s12887-026-07464-4 [doi] LID - 879 AB - OBJECTIVE: This study aimed to evaluate the relationship between pancreatic steatosis and fecal elastase (FE) levels in children with hepatic steatosis, compare clinical, metabolic, and imaging findings according to metabolic dysfunction-associated steatotic liver disease (MASLD) status, and determine whether this relationship persists within children with MASLD. METHODS: This prospective cross-sectional study was conducted in the Pediatric Gastroenterology and Pediatric Endocrinology Departments of Kayseri City Hospital. Participants were classified according to the presence of MASLD. Clinical characteristics, anthropometric measurements, metabolic parameters, ultrasonographic findings, and FE levels were compared between groups. FE levels were categorized as normal (> 200 microg/g), low (100-200 microg/g), and severely low (< 100 microg/g). For binary analyses, low FE was defined as /=95th percentile (OR: 3.31, 95% CI: 1.24-8.87, p = 0.017) were independently associated with low FE levels. Within the MASLD group, pancreatic steatosis grade was significantly associated with low FE levels. Pancreatic steatosis grade showed the highest discriminatory performance for low FE levels among the evaluated parameters (AUC = 0.76). CONCLUSIONS: Pancreatic steatosis was more frequent in children with MASLD, and its severity was associated with low FE levels both in the overall cohort and within the MASLD group. Imaging-based pancreatic findings showed moderate discriminatory performance for low FE levels but should not be interpreted as validated diagnostic thresholds. Pancreatic steatosis may represent a clinically relevant feature of pediatric MASLD in relation to possible subclinical alterations in exocrine pancreatic function. CI - (c) 2026. The Author(s). FAU - Daldaban Sarica, Buket AU - Daldaban Sarica B AD - Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, University of Health Sciences, Kayseri City Hospital, Kayseri, Turkiye. buketdaldaban@gmail.com. FAU - Gumus, Ummugulsum Ozgul AU - Gumus UO AD - Department of Radiology, Division of Pediatric Radiology, University of Health Sciences, Kayseri City Hospital, Kayseri, Turkiye. FAU - Kara, Leyla AU - Kara L AD - Department of Pediatrics, Division of Endocrinology, University of Health Sciences, Kayseri City Hospital, Kayseri, Turkiye. FAU - Gok, Ebru AU - Gok E AD - Department of Pediatrics, Division of Endocrinology, University of Health Sciences, Kayseri City Hospital, Kayseri, Turkiye. FAU - Koca, Serkan Bilge AU - Koca SB AD - Department of Pediatrics, Division of Endocrinology, University of Health Sciences, Kayseri City Hospital, Kayseri, Turkiye. FAU - Kirkgoz, Tarik AU - Kirkgoz T AD - Department of Pediatrics, Division of Endocrinology, University of Health Sciences, Kayseri City Hospital, Kayseri, Turkiye. LA - eng PT - Journal Article DEP - 20260826 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - EC 3.4.21.36 (Pancreatic Elastase) SB - IM MH - Humans MH - Cross-Sectional Studies MH - Prospective Studies MH - Male MH - Female MH - Child MH - *Pancreatic Elastase/analysis/metabolism MH - *Pancreatic Diseases/complications/etiology MH - Feces/enzymology/chemistry MH - *Exocrine Pancreatic Insufficiency/etiology MH - *Pancreas, Exocrine/physiopathology MH - Adolescent MH - Ultrasonography PMC - PMC13584307 OTO - NOTNLM OT - Fecal elastase OT - Metabolic dysfunction-associated steatotic liver disease OT - Pancreatic exocrine function OT - Pancreatic fat infiltration COIS- Declarations. Ethics approval and consent to participate: Ethical approval for this study was granted by the Clinical Research Ethics Committee of Kayseri City Hospital on January 14, 2026, with approval decision number 752. The study was conducted in accordance with the principles of the Declaration of Helsinki (1964), as revised in 2013. Written informed consent to participate was obtained from the participants' parents or legal guardians; specifically, parental or legal guardian consent was obtained for every participant younger than 16 years. Consent for publication: Not appilicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/17 05:35 MHDA- 2026/09/17 05:36 PMCR- 2026/08/26 CRDT- 2026/09/16 23:55 PHST- 2026/05/21 00:00 [received] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/09/17 05:36 [medline] PHST- 2026/09/17 05:35 [pubmed] PHST- 2026/09/16 23:55 [entrez] PHST- 2026/08/26 00:00 [pmc-release] AID - 10.1186/s12887-026-07464-4 [pii] AID - 7464 [pii] AID - 10.1186/s12887-026-07464-4 [doi] PST - epublish SO - BMC Pediatr. 2026 Aug 26;26(1):879. doi: 10.1186/s12887-026-07464-4. PMID- 42749631 OWN - NLM STAT- Publisher LR - 20260916 IS - 1348-4540 (Electronic) IS - 0918-8959 (Linking) DP - 2026 Sep 15 TI - Association between fasting plasma glucose at diagnosis and large-for-gestational-age in Japanese women with gestational diabetes mellitus: Hamamatsu GRACE Study 6. LID - 10.1507/endocrj.EJ26-0368 [doi] AB - Maternal high fasting plasma glucose (FPG) is a well-known risk factor for large-for-gestational-age (LGA) infants. However, this association remains unclear among Japanese women with gestational diabetes mellitus (GDM). Therefore, we examined this issue in Japanese women with GDM, accounting for body mass index (BMI). This retrospective study analyzed 543 Japanese women with GDM and evaluated the associations of 1-standard deviation (SD) increments in fasting, 1-hour, and 2-hour plasma glucose and HbA1c levels with LGA. LGA was defined as birth weight above the 90th percentile for gestational age. Multivariable logistic regression was used to estimate ORs and 95% CIs for LGA per 1-SD increment in fasting, 1-hour, and 2-hour plasma glucose and HbA1c. Model 1 was adjusted for maternal age, smoking, family history of diabetes, insulin use, parity, gestational age at delivery, gestational age at diagnosis, and gestational weight gain; Model 2 was additionally adjusted for pre-pregnancy BMI. The prevalence of LGA was 9.6%. In model 1, the FPG was independently and positively associated with LGA (adjusted OR 1.44, 95% CI: 1.07-1.94). The area under the receiver operating characteristic (ROC) curve for FPG in discriminating LGA was 0.692, with an optimal cutoff of 86.0 mg/dL. After additional adjustment for pre-pregnancy BMI (model 2), FPG was no longer associated with LGA. Other glycemic parameters were not associated with low birth weight, small-for-gestational-age, or LGA. FPG at GDM diagnosis may provide limited discriminatory information for LGA. However, its association with LGA was attenuated after adjustment for pre-pregnancy BMI. FAU - Tsuriya, Daisuke AU - Tsuriya D AUID- ORCID: 0009-0001-7891-5046 AD - Division of Endocrinology and Metabolism, Second Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan. FAU - Takeshita, Kei AU - Takeshita K AUID- ORCID: 0009-0008-1123-5581 AD - Division of Endocrinology and Metabolism, Second Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan. FAU - Toyama, Yukino AU - Toyama Y AUID- ORCID: 0009-0003-0214-0947 AD - Division of Endocrinology and Metabolism, Second Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan. FAU - Hashimoto, Takuya AU - Hashimoto T AUID- ORCID: 0000-0002-6761-0343 AD - Division of Endocrinology and Metabolism, Second Department of Internal Medicine, Hamamatsu University School of Medicine, Shizuoka 431-3192, Japan. FAU - Kanamoto, Ayumi AU - Kanamoto A AUID- ORCID: 0009-0001-9894-9120 AD - Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime 790-0294, Japan. FAU - Miyake, Teruki AU - Miyake T AUID- ORCID: 0000-0002-9905-5356 AD - Department of Lifestyle-Related Medicine and Endocrinology, Ehime University Graduate School of Medicine, Ehime 790-0294, Japan. FAU - Furukawa, Shinya AU - Furukawa S AUID- ORCID: 0000-0002-0041-7688 AD - Health Services Center, Ehime University, Ehime 790-8577, Japan. LA - eng PT - Journal Article DEP - 20260915 PL - Japan TA - Endocr J JT - Endocrine journal JID - 9313485 SB - IM OTO - NOTNLM OT - Body mass index OT - Fetal outcomes OT - Gestational diabetes mellitus EDAT- 2026/09/16 23:34 MHDA- 2026/09/16 23:34 CRDT- 2026/09/16 22:13 PHST- 2026/09/16 23:34 [medline] PHST- 2026/09/16 23:34 [pubmed] PHST- 2026/09/16 22:13 [entrez] AID - 10.1507/endocrj.EJ26-0368 [doi] PST - aheadofprint SO - Endocr J. 2026 Sep 15. doi: 10.1507/endocrj.EJ26-0368. PMID- 42749612 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261007 IS - 1871-403X (Print) IS - 1871-403X (Linking) VI - 20 IP - 5 DP - 2026 Sep-Oct TI - Urinary metabolomic profiling reveals distinct metabolic characteristics in children with overweight and obesity. PG - 409-417 LID - S1871-403X(26)00087-6 [pii] LID - 10.1016/j.orcp.2026.09.003 [doi] AB - BACKGROUND: Childhood obesity is a critical global public health problem. Untargeted metabolomics can identify metabolic alterations associated with childhood obesity, but pediatric evidence remains limited. This study characterized urinary metabolic profiles associated with overweight and obesity in children. METHODS: A total of 120 first-grade primary school children were selected. The population comprised 40 children with normal weight, 40 children with overweight, and 40 children with obesity, with equal sex distribution in each group. Urinary metabolic profiles were analyzed using liquid chromatography-mass spectrometry-based untargeted metabolomics, followed by multivariate analysis, differential feature analysis, pathway enrichment analysis, and ROC analysis. RESULTS: Compared with children with normal weight, children with overweight showed 69 differential metabolic features (40 upregulated and 29 downregulated), whereas children with obesity showed 193 (161 upregulated and 32 downregulated). Three of 37 and 15 of 83 pathways, respectively, met the exploratory criteria of raw P < 0.05 and pathway impact > 0.01. After FDR correction, two and four pathways remained statistically significant, respectively. Phenylalanine metabolism (FDR=0.015 and 0.001, respectively) and phenylalanine, tyrosine and tryptophan biosynthesis (FDR=0.036 and 0.012, respectively) were significant in both comparisons with the normal-weight group. Thirteen metabolic features showed discriminatory potential between children with obesity and children with normal weight, with N-acetyl-D-glucosamine showing an AUC of 0.889 (95% CI: 0.821-0.958). CONCLUSION: This study characterized urinary metabolic alterations and enriched pathways associated with overweight and obesity in children compared with normal weight. Several candidate metabolic features showed exploratory discriminatory potential but require targeted confirmation and independent validation. CI - Copyright (c) 2026 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved. FAU - Chen, Yingzi AU - Chen Y AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China. FAU - Wen, Xiaosa AU - Wen X AD - Minhang District Centre for Disease Control and Prevention, Shanghai, China. FAU - He, Guanhao AU - He G AD - Department of Public Health and Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China. FAU - Yu, Dan AU - Yu D AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China. FAU - Xu, Su AU - Xu S AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China. FAU - Ruan, Zengliang AU - Ruan Z AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, School of Public Health, Southeast University, Nanjing, China; Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Electronic address: rzl@seu.edu.cn. LA - eng PT - Journal Article DEP - 20260917 PL - Netherlands TA - Obes Res Clin Pract JT - Obesity research & clinical practice JID - 101303911 RN - 0 (Biomarkers) RN - 47E5O17Y3R (Phenylalanine) RN - 8DUH1N11BX (Tryptophan) RN - 42HK56048U (Tyrosine) SB - IM MH - Humans MH - Child MH - Male MH - Female MH - *Metabolomics/methods MH - *Pediatric Obesity/urine/metabolism MH - *Overweight/urine MH - *Metabolome MH - Body Mass Index MH - Biomarkers/urine MH - Phenylalanine/urine MH - Tryptophan/urine MH - Chromatography, Liquid MH - Tyrosine/urine OTO - NOTNLM OT - Childhood obesity OT - Metabolic pathways OT - Overweight OT - Untargeted metabolomics OT - Urinary metabolomics COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper EDAT- 2026/09/16 23:34 MHDA- 2026/10/07 23:30 CRDT- 2026/09/16 22:05 PHST- 2026/01/20 00:00 [received] PHST- 2026/09/10 00:00 [revised] PHST- 2026/09/13 00:00 [accepted] PHST- 2026/10/07 23:30 [medline] PHST- 2026/09/16 23:34 [pubmed] PHST- 2026/09/16 22:05 [entrez] AID - S1871-403X(26)00087-6 [pii] AID - 10.1016/j.orcp.2026.09.003 [doi] PST - ppublish SO - Obes Res Clin Pract. 2026 Sep-Oct;20(5):409-417. doi: 10.1016/j.orcp.2026.09.003. Epub 2026 Sep 17. PMID- 42748416 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20260916 IS - 1745-5065 (Electronic) IS - 1745-5057 (Linking) VI - 22 DP - 2026 Jan-Dec TI - Genitourinary syndrome of lactation: An underrecognized postpartum condition affecting women's vulvovaginal, urinary and sexual health. PG - 17455057261490606 LID - 10.1177/17455057261490606 [doi] AB - Postpartum care is increasingly viewed as a continuum of maternal recovery rather than a single visit at six weeks. Within this broader view, however, the genitourinary and sexual health of breastfeeding women remains insufficiently addressed. Genitourinary syndrome of lactation (GSL) has recently been proposed to describe postpartum and lactation-related vulvovaginal, urinary and sexual symptoms that may be linked to the hypoestrogenic hormonal environment of breastfeeding. During lactation, suckling-related prolactin secretion suppresses hypothalamic-pituitary-ovarian activity and may maintain low estradiol levels, particularly during amenorrhea. Although the term deliberately echoes genitourinary syndrome of menopause, GSL belongs to a different clinical setting: a woman recovering from pregnancy and birth, adapting to breastfeeding, living with sleep deprivation and body changes, and gradually rebuilding sexual intimacy. This narrative perspective review summarizes the emerging evidence on GSL and offers a practical framework for recognition, differential diagnosis, screening and breastfeeding-supportive management. GSL should not be reduced to vaginal dryness, nor should every postpartum sexual or urinary symptom be attributed to lactation-related hormonal deprivation. Assessment should consider perineal scar pain, pelvic floor dysfunction, vestibulodynia, vulvovaginal infections, vulvar dermatoses, urinary tract disorders, hormonal contraception and psychosocial contributors; bowel symptoms may indicate broader pelvic floor or obstetric injury rather than GSL itself. Management is best approached in a stepped and individualized manner, beginning with education, validation, vulvar care, lubricants, vaginal moisturizers, pelvic floor physiotherapy and sexual counselling when indicated. For persistent moderate-to-severe mucosal symptoms, low-dose vaginal estrogen is a reasonable option after shared decision-making, particularly once lactation is established. Vaginal prasterone lacks lactation-specific safety and efficacy evidence and cannot currently be recommended routinely. Recognizing GSL is not an argument against breastfeeding; it is a way to make postpartum care more complete. FAU - Orozco Fernandez, Rodrigo AU - Orozco Fernandez R AUID- ORCID: 0000-0001-7521-0676 AD - Department of Obstetrics and Gynecology, Hospital Quironsalud Malaga, Malaga, Spain. RINGGOLD: 221954 AD - Department of Obstetrics and Gynecology, Clinica Palacios Malaga, Malaga, Spain. FAU - Gil-Antunano, Santiago Palacios AU - Gil-Antunano SP AD - Department of Obstetrics and Gynecology, Clinica Palacios Madrid, Madrid, Spain. LA - eng PT - Journal Article PT - Review DEP - 20260916 PL - United States TA - Womens Health (Lond) JT - Women's health (London, England) JID - 101271249 SB - IM MH - Humans MH - Female MH - *Lactation/physiology MH - *Breast Feeding/adverse effects MH - *Postpartum Period MH - *Sexual Health MH - Syndrome MH - *Female Urogenital Diseases/diagnosis MH - Pregnancy MH - Sexual Dysfunction, Physiological OAB - Many women experience vaginal dryness, burning, pain during sex, urinary discomfort or loss of sexual confidence after childbirth, especially while breastfeeding. These problems are often dismissed as a normal part of having a baby, even when they affect comfort, relationships and quality of life. This review discusses the recently proposed term "genitourinary syndrome of lactation", which describes genital, urinary and sexual symptoms that may be linked partly to the temporary hormonal changes associated with breastfeeding. However, not every symptom after childbirth has the same cause. Pain from scars, pelvic floor problems, infections, skin conditions, urinary disorders, tiredness, anxiety and relationship difficulties may also contribute and should be assessed. The article proposes a practical approach for healthcare professionals. Women should be asked directly and sensitively about dryness, pain, urinary symptoms and the effect on their wellbeing. Treatment should be tailored to the main cause and may include information and reassurance, gentle vulval care, lubricants, vaginal moisturisers, pelvic floor physiotherapy and sexual counselling. Low-dose vaginal oestrogen may be a reasonable option for persistent or more troublesome symptoms after an individual discussion of benefits, uncertainties and breastfeeding circumstances. Other hormonal treatments, such as vaginal prasterone, require more research during breastfeeding. Recognising these symptoms does not mean that breastfeeding is harmful. It means that breastfeeding support should also include the mother's physical comfort, sexual health and quality of life. OABL- eng OTO - NOTNLM OT - breastfeeding OT - dyspareunia OT - fourth trimester OT - genitourinary syndrome of lactation OT - hypoestrogenism OT - lactation OT - postpartum period OT - sexual health OT - urinary symptoms OT - vulvovaginal symptoms COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/09/16 17:36 MHDA- 2026/09/16 17:37 CRDT- 2026/09/16 16:43 PHST- 2026/09/16 17:37 [medline] PHST- 2026/09/16 17:36 [pubmed] PHST- 2026/09/16 16:43 [entrez] AID - 10.1177/17455057261490606 [doi] PST - ppublish SO - Womens Health (Lond). 2026 Jan-Dec;22:17455057261490606. doi: 10.1177/17455057261490606. Epub 2026 Sep 16. PMID- 42747779 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261010 IS - 1708-0428 (Electronic) IS - 0960-8923 (Linking) VI - 36 IP - 10 DP - 2026 Oct TI - Ethical Dimensions of Bariatric Surgery: A Narrative Review of Principles, Challenges, and Practice Implications. PG - 5498-5509 LID - 10.1007/s11695-026-08933-6 [doi] AB - Metabolic and bariatric surgery (MBS) is among the most effective interventions for severe obesity, with contemporary outcomes best reported as percentage total weight loss (%TWL), yet it raises ethical challenges distinct from many other surgical disciplines. This SANRA-guided narrative review synthesizes ethical issues across the adult bariatric patient journey using Beauchamp and Childress' four principles: autonomy, beneficence, non-maleficence, and justice. Key tensions include safeguarding consent validity amid obesity stigma and desperation bias; balancing patient autonomy with assessment of co-occurring psychiatric conditions, including a reported five-year cumulative incidence of new alcohol use disorder symptoms of approximately 21% after Roux-en-Y gastric bypass; addressing long-term nutritional, psychological, and follow-up obligations; adapting communication for collectivist contexts; and engaging the implications of obesity management medications, telemedicine, and artificial intelligence. Ethical bariatric practice requires multimodal consent, individualized multidisciplinary candidacy assessment, equity-oriented access policies, and durable systems for long-term postoperative care. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Soltani, Hamid Reza AU - Soltani HR AUID- ORCID: 0000-0002-5045-978X AD - Department of General Surgery, Shahid Sadoughi University of Medical Sciences, Yazd, Islamic Republic of Iran. hrsgmed@yahoo.com. FAU - Toolabi, Karamollah AU - Toolabi K AD - Department of Minimally Invasive and Bariatric Surgery, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. FAU - Sadat-Safavi, Seyed Abbas AU - Sadat-Safavi SA AD - Department of Minimally Invasive and Bariatric Surgery, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. FAU - Najjari, Khosrow AU - Najjari K AD - Department of Minimally Invasive and Bariatric Surgery, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. FAU - Latif, Amirhossein AU - Latif A AUID- ORCID: 0000-0002-8248-7662 AD - Department of Minimally Invasive and Bariatric Surgery, Tehran University of Medical Sciences, Tehran, Islamic Republic of Iran. LA - eng PT - Journal Article PT - Review DEP - 20260916 PL - United States TA - Obes Surg JT - Obesity surgery JID - 9106714 SB - IM MH - Humans MH - *Bariatric Surgery/ethics MH - *Obesity, Morbid/surgery/psychology MH - Personal Autonomy MH - Informed Consent/ethics MH - Beneficence MH - Social Stigma MH - Ethical Dilemmas OTO - NOTNLM OT - Bariatric surgery OT - Ethics, medical OT - Health equity OT - Informed consent OT - Metabolic surgery OT - Obesity OT - Personal autonomy OT - Social stigma COIS- Declarations. Ethics Approval and Consent to Participate: This study is a narrative review of previously published literature and did not involve human participants, animal subjects, or identifiable patient data. Accordingly, ethical approval was not required, and no patient consent was obtained. Consent for Publication: Not applicable. Patient and Public Involvement Statement: Patients and members of the public were not directly involved in this narrative review. Future empirical and consensus-based work should include patient and public involvement to ensure that bariatric ethics frameworks reflect patient priorities, decisional experiences, follow-up barriers, and perceptions of equitable care. AI Tool Use Disclosure: AI-assisted writing tools were used during the preparation of this manuscript for language editing and structural refinement. All intellectual content, interpretation, and conclusions are the sole responsibility of the authors. The authors have reviewed and take full responsibility for the final text. Competing Interests: The authors declare no competing interests. Clinical Trial Registration: Not applicable. EDAT- 2026/09/16 17:36 MHDA- 2026/10/07 17:33 CRDT- 2026/09/16 11:41 PHST- 2026/06/08 00:00 [received] PHST- 2026/09/12 00:00 [accepted] PHST- 2026/08/20 00:00 [revised] PHST- 2026/10/07 17:33 [medline] PHST- 2026/09/16 17:36 [pubmed] PHST- 2026/09/16 11:41 [entrez] AID - 10.1007/s11695-026-08933-6 [pii] AID - 10.1007/s11695-026-08933-6 [doi] PST - ppublish SO - Obes Surg. 2026 Oct;36(10):5498-5509. doi: 10.1007/s11695-026-08933-6. Epub 2026 Sep 16. PMID- 42747402 OWN - NLM STAT- Publisher LR - 20260916 IS - 1876-3405 (Electronic) IS - 1876-3405 (Linking) DP - 2026 Sep 16 TI - An exploratory study to describe the growth and neurodevelopmental status of low birthweight infants in the context of a community-based mother-to-mother peer support implementation program in Kenya. LID - ihag076 [pii] LID - 10.1093/inthealth/ihag076 [doi] AB - BACKGROUND: This article examines changes in mothers' knowledge of low birthweight (LBW; <2500 g) infant care practices in a study assessing the feasibility and acceptability of peer mother support post-discharge, explores the acceptability of the intervention among mothers and healthcare workers and describes the post-intervention growth and neurodevelopmental status of the LBW infants. METHODS: A mixed methods exploratory study, using questionnaires, semi-structured interviews and focus group discussions with mothers, healthcare providers and peer mothers was conducted in three health facilities in Homa Bay County, western Kenya. Peer mothers delivered the interventions (including breastfeeding support) to mother-LBW infant pairs at 24 h post-discharge and six other time points until 3 months after birth. Infant anthropometric assessments were done at birth, discharge and 3 months after birth, while neurodevelopmental assessment was done only at 3 months using the Malawi Developmental Assessment Tool. Descriptive statistics were used to analyse the quantitative data. A thematic framework was used to analyse the qualitative data. RESULTS: Sixty mother-LBW infant pairs were enrolled in the study, but only 55 were included in the analysis because 5 mothers and their LBW infants were lost to follow-up. The median birthweight was 2050 g, median discharge weight was 2100 g and median weight gain 3 months after birth was 2820 g. The weight-for-age z-scores increased by 0.3 from birth to 3 months; similarly, the weight-for-length z-score increased by approximately 0.2. However, the length for age Z-score decreased by 0.3. At 3 months, 96% (n=53) of LBW infants had achieved their gross motor, 71% (n=42) fine motor, 89% (n=49) language and 100% social milestones. The intervention improved maternal knowledge and practice of recommended LBW infant care strategies, promoted resilience and enhanced family relationships. CONCLUSION: This exploratory study suggests that a mother-to-mother peer support intervention improved maternal knowledge, care practices and empowerment in the post-discharge care of LBW infants in a resource-limited setting. Further refinement and rigorous evaluation are needed to generate robust evidence on its effectiveness and impact on growth and neurodevelopmental outcomes. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Royal Society of Tropical Medicine and Hygiene. FAU - Nabwera, Helen M AU - Nabwera HM AUID- ORCID: 0000-0003-1056-729X AD - Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK. AD - Aga Khan University, Centre of Excellence for Women and Child Health, P.O. Box 30270 - 00100, Nairobi, Kenya. FAU - Parekh, Meera AU - Parekh M AUID- ORCID: 0009-0004-5132-0220 AD - Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK. AD - University of Liverpool, Ashton Street, Liverpool L69 3GE, UK. FAU - Gaetean, Brezesky K AU - Gaetean BK AD - London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. FAU - Achieng Were, Florence AU - Achieng Were F AD - KEMRI-Centre for Global Health Research, P.O. Box 1578-40100, Kisumu, Kenya. FAU - Agbla, Schadrac AU - Agbla S AD - University of Liverpool, Ashton Street, Liverpool L69 3GE, UK. AD - London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK. FAU - Barsosio, Hellen C AU - Barsosio HC AD - Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK. AD - KEMRI-Centre for Global Health Research, P.O. Box 1578-40100, Kisumu, Kenya. FAU - Tindi, Linda AU - Tindi L AD - Homa Bay County Teaching and Referral Hospital, 52-40300 Homa Bay, Kenya. FAU - Boga, Mwanamvua AU - Boga M AD - KEMRI-Wellcome Trust Research Programme, P.O. Box 230-80108, Kilifi, Kenya. FAU - Kimani, Mary AU - Kimani M AD - Action Against Hunger, Old Dagoretti Estate Gate, off Ngong Road, Nairobi, Kenya. FAU - Juma, Dan AU - Juma D AD - KEMRI-Centre for Global Health Research, P.O. Box 1578-40100, Kisumu, Kenya. FAU - Kiige, Laura AU - Kiige L AD - UNICEF Kenya, P.O. Box 44145-00100, Nairobi, Kenya. FAU - Manu, Alexander AU - Manu A AD - Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK. FAU - Kariuki, Simon AU - Kariuki S AD - KEMRI-Centre for Global Health Research, P.O. Box 1578-40100, Kisumu, Kenya. FAU - Mwangome, Martha K AU - Mwangome MK AUID- ORCID: 0000-0003-4806-1307 AD - KEMRI-Wellcome Trust Research Programme, P.O. Box 230-80108, Kilifi, Kenya. FAU - Pyone, Thidar AU - Pyone T AD - Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK. FAU - Gladstone, Melissa AU - Gladstone M AD - University of Liverpool, Ashton Street, Liverpool L69 3GE, UK. FAU - Mathai, Matthews AU - Mathai M AD - Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK. LA - eng GR - Liverpool School of Tropical Medicine/ GR - UK Medical Research Council/ GR - MRC/ GR - FCDO/ GR - European Union/ PT - Journal Article DEP - 20260916 PL - England TA - Int Health JT - International health JID - 101517095 SB - IM OTO - NOTNLM OT - Kenya OT - community-based interventions OT - low birthweight infants OT - neurodevelopment OT - peer mothers EDAT- 2026/09/16 11:41 MHDA- 2026/09/16 11:41 CRDT- 2026/09/16 10:44 PHST- 2025/06/09 00:00 [received] PHST- 2026/06/14 00:00 [revised] PHST- 2026/07/03 00:00 [accepted] PHST- 2026/09/16 11:41 [medline] PHST- 2026/09/16 11:41 [pubmed] PHST- 2026/09/16 10:44 [entrez] AID - 8802187 [pii] AID - 10.1093/inthealth/ihag076 [doi] PST - aheadofprint SO - Int Health. 2026 Sep 16:ihag076. doi: 10.1093/inthealth/ihag076. PMID- 42746181 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260916 LR - 20260917 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 8 DP - 2026 Aug TI - Subconscious Restructuring Protocol in a Mental Health Quality Improvement Study: Reduced Treatment Duration and Improvement Across 17 Psychometric Outcomes in Adult Civilians, Veterans, and Adolescents. PG - e114583 LID - 10.7759/cureus.114583 [doi] LID - e114583 AB - BACKGROUND: Conventional psychiatric and psychotherapeutic services typically require extended treatment durations while collecting limited outcome data, producing inconsistent care. Subconscious Restructuring (SR) uses a behavioral microbiome model treating psychological symptoms and gut barrier integrity as a single clinical target, on the premise that a compromised gut barrier permits translocation of lipopolysaccharide and Candida, activating microglia and the neuroinflammation implicated in depression, anxiety, and post-traumatic stress disorder (PTSD). The model is the rationale for the protocol's dual target, not a hypothesis tested here. SR is cloud-based, scripted, and auditable, capturing session-level client-generated data, and has been in clinical use since 1990; it is mechanistic rather than symptom-based, so no personal history is required for delivery. This quality improvement (QI) initiative aimed to improve the efficiency and clinical outcomes of care by delivering a standardized brief emotional fitness protocol through the SR framework. METHODOLOGY: This initiative used Plan-Do-Study-Act cycles with 50 clients across three populations (20 adult civilians, 20 military veterans, 10 adolescents) in multi-site clinical practices. The protocol comprised two two-hour sessions on consecutive days plus three one-hour follow-ups for adult civilians, two two-hour sessions for veterans, and a single four-hour session for adolescents, delivered as extended workshop-format blocks rather than 50-minute appointments. Sixteen psychometric metrics and a derived Stress Load Index were measured, alongside adherence, completion, and safety. The Gut Health Symptom Checklist was completed at every session as a physician-referral gate, not an outcome measure; no gut health data were analyzed. Change was summarized as the mean change in scale points with SD, 95% CI, percent improvement, and within-subject standardized mean change (d_z); paired t-tests are descriptive. RESULTS: Treatment duration was reduced by 67.5% relative to the 16-hour midpoint of the conventional 12-20-session benchmark, ranging from 56.7% to 74.0% against its 12-hour and 20-hour bounds. Adherence and assessment completion were 100% with no adverse events. Mean improvement across the 17 outcomes was 35.2% for adults, 47.3% for veterans, and 19.1% for adolescents; pooled across 50 clients, depression (Emotional Checklist total) improved 46.63%. Veterans achieved the strongest gains (depression: 57.87%, anger: 63.95%, Stress Load Index: 46.25%). Every outcome improved in raw scale points in all three cohorts, but the adolescent response was smaller and more variable, with 10 of 16 intervals, including zero; its two negative percentages are floor and ceiling artifacts on hopelessness and relationship satisfaction. Standardized Cronbach's alpha was 0.93 for the valence-aligned overall scale, and d_z ranged from 0.04 to 2.04. Reliable improvement on the primary symptom instrument reached 90.0% of veterans, 60.0% of adults, and 50.0% of adolescents; on at least one instrument, these were 95.0%, 95.0%, and 50.0%, respectively. CONCLUSIONS: Standardized brief emotional fitness protocols were associated with improvements in both clinical outcomes and service delivery efficiency. This model offers a replicable framework for reducing treatment timelines; controlled studies are needed to confirm effects on mental health outcomes. CI - Copyright (c) 2026, Burris et al. FAU - Burris, Kelly AU - Burris K AD - Behavioral Health, Burris Institute, Los Angeles, USA. LA - eng PT - Journal Article DEP - 20260815 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13575544 OTO - NOTNLM OT - behavioral microbiome OT - gut-brain axis OT - mental health service delivery OT - pdsa cycles OT - psychophysiological intervention OT - quality improvement OT - routine outcome monitoring OT - standardized mean change OT - treatment duration reduction OT - veteran mental health COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Burris Institute issued approval dated August 12, 2026. This quality improvement activity was determined to be exempt from the institutional review board (IRB) review as an activity not constituting human subjects research, under 45 CFR 46.102(l) and U.S. Office for Human Research Protections (OHRP) guidance on quality improvement activities. Because the Burris Institute maintains no standing institutional review board, the determination was made by the principal investigator on June 5, 2025. As a condition of enrollment in the SR workshops, all participants agreed that their de-identified data could be used for study and evaluation, and no individually identifiable information would be reported. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: Kelly Burris declare(s) personal fees, non-financial support, employment and royalties from Burris Institute. Kelly Burris is the founder of the Burris Institute, which owns the Subconscious Restructuring intellectual property and the assessment instruments described in this manuscript, and which licenses the Burris Connect practitioner platform on an annual subscription basis. The author derives income from the Institute, including from practitioner certification training and platform subscriptions. No payments, grants, honoraria, consultancies, equity, or other compensation were received from any third party in connection with this work or any related activity. Intellectual property info: The SR guidelines and protocol materials are proprietary works copyrighted and trademarked by the Burris Institute and are provided to practitioners who complete the SR certification training. The assessment instruments used in this study are reproduced in full in the appendices and are freely available for research and clinical use. Other relationships: The author developed the intervention evaluated here, developed the assessment instruments used to evaluate it, and owns the entity that commercializes both. The practitioners who collected the data are certified under the author's training program. Readers should be aware that the author has a professional and financial interest in the framework being evaluated. No external party had any role in the design, conduct, analysis, or reporting of this evaluation, and the author had full access to and responsibility for the data. EDAT- 2026/09/16 11:41 MHDA- 2026/09/16 11:42 PMCR- 2026/08/15 CRDT- 2026/09/16 05:40 PHST- 2026/08/15 00:00 [accepted] PHST- 2026/09/16 11:42 [medline] PHST- 2026/09/16 11:41 [pubmed] PHST- 2026/09/16 05:40 [entrez] PHST- 2026/08/15 00:00 [pmc-release] AID - 10.7759/cureus.114583 [doi] PST - epublish SO - Cureus. 2026 Aug 15;18(8):e114583. doi: 10.7759/cureus.114583. eCollection 2026 Aug. PMID- 42746112 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20260917 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Antibiotic-induced gut microbiota dysbiosis in the PICU: mechanisms, clinical outcomes, and management strategies - a narrative review. PG - 1910105 LID - 10.3389/fimmu.2026.1910105 [doi] LID - 1910105 AB - BACKGROUND: Antibiotic exposure is highly prevalent in the paediatric intensive care unit (PICU) and constitutes a major modifiable driver of gut microbiota dysbiosis. However, a systematic synthesis focusing specifically on the PICU population has been lacking. This narrative review addresses how antibiotic exposure drives gut dysbiosis in the PICU, its clinical consequences with emphasis on immunological pathways, and its management. METHODS: This review was informed by a structured search of PubMed, Web of Science, Cochrane Library, and Chinese databases up to June 2026, including studies on antibiotic exposure, microbiota alterations, clinical outcomes, and management in critically ill children. RESULTS: Antibiotic use in PICU children ranges from 58% to 94%, with broad-spectrum and combination therapy being common. Anti-anaerobic antibiotics-particularly piperacillin-tazobactam, meropenem, and clindamycin-cause the most pronounced disruption, as quantified in adult ICU cohorts. In PICU children, clinical consequences include a higher incidence of Clostridioides difficile infection and an increased risk of ventilator-associated pneumonia following carbapenem exposure. Antibiotic stewardship, encompassing de-escalation and avoidance of unnecessary anaerobic coverage, is the first-line microbiota protection strategy. Probiotics reduce ventilator-associated pneumonia and shorten PICU stay, but should not be used routinely in high-risk children. High-fibre enteral nutrition has shown feasibility, whereas postbiotics and faecal microbiota transplantation lack PICU-specific trial data. CONCLUSIONS: Antibiotics are among the most significant modifiable drivers of gut dysbiosis in the PICU, with dose-dependent, class-specific effects. Antibiotic stewardship should be prioritised before any microbiota-directed intervention. Live probiotics require caution in high-risk populations, while non-live interventions are promising but need larger trials. Future research should employ longitudinal, multicentre studies with standardised reporting to elucidate host-microbe interactions in critically ill children. CI - Copyright (c) 2026 Yang, Wang and Peng. FAU - Yang, Cheng AU - Yang C AD - Department of Paediatric Intensive Care Unit Nursing, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Department of Paediatric Intensive Care Unit Nursing, WCSUH-Tianfu.Sichuan Provincial Children's Hospital, Meishan, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. FAU - Wang, Dandan AU - Wang D AD - The Second Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital, Chengdu, China. FAU - Peng, Wentao AU - Peng W AD - Department of Nursing, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Department of Nursing, WCSUH-Tianfu.Sichuan Provincial Children's Hospital, Meishan, China. LA - eng PT - Journal Article PT - Review DEP - 20260901 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Anti-Bacterial Agents) SB - IM MH - Humans MH - *Dysbiosis/chemically induced/therapy MH - *Gastrointestinal Microbiome/drug effects MH - *Intensive Care Units, Pediatric MH - *Anti-Bacterial Agents/adverse effects MH - Child MH - Critical Illness PMC - PMC13575818 OTO - NOTNLM OT - PICU OT - antibiotic stewardship OT - dysbiosis OT - gut microbiota OT - microbiome OT - sepsis COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/16 11:41 MHDA- 2026/09/16 11:42 PMCR- 2026/09/01 CRDT- 2026/09/16 05:32 PHST- 2026/06/15 00:00 [received] PHST- 2026/07/24 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/09/16 11:42 [medline] PHST- 2026/09/16 11:41 [pubmed] PHST- 2026/09/16 05:32 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1910105 [doi] PST - epublish SO - Front Immunol. 2026 Sep 1;17:1910105. doi: 10.3389/fimmu.2026.1910105. eCollection 2026. PMID- 42744370 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260922 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 9 DP - 2026 Sep 15 TI - Characterising the pharmacokinetics of olanzapine in patients with anorexia nervosa (TORPEDO): protocol for a multicentre cross-sectional study. PG - e119486 LID - 10.1136/bmjopen-2026-119486 [doi] LID - e119486 AB - INTRODUCTION: Anorexia nervosa (AN) is a debilitating eating disorder with one of the highest mortality rates of all psychiatric disorders. The lifetime prevalence rates of AN might be up to 4% among females and 0.3% among males. According to a systematic review, the pooled incidence rate of AN in females is 8.8 per 100 000 person-years; 95% CI 7.8 to 9.8. The path towards full recovery is often long and only half of the patients recover completely after 10 years. As part of the treatment of AN, olanzapine is frequently used to reduce severe anxiety, agitation and obsessive compulsions. Due to a dearth of pharmacokinetic studies on olanzapine in this population with altered body composition, and side effects, doctors often dose low out of precaution. These low doses are potentially subtherapeutic and elongate the progression and the treatment. In this study, we aim to research the pharmacokinetics of olanzapine in AN patients to facilitate more adequate dosing strategies in this vulnerable group. METHODS AND ANALYSIS: Towards precision dosing of olanzapine in anorexia nervosa patients (TORPEDO) is a multicentre, cross-sectional observational study. It includes patients aged 12-30 years who are being treated with olanzapine for either AN (n=30) or other non-AN psychiatric indications (n=30). The aim is to develop population pharmacokinetic models of patients with AN and those without, in order to compare how AN affects the pharmacokinetics of olanzapine. Olanzapine plasma day-curve will be obtained using capillary micro sampling. In a secondary analysis, we will examine associations between olanzapine pharmacokinetic parameters and clinical outcomes, including treatment effectiveness, extrapyramidal side effects, cardiac abnormalities and metabolic laboratory markers. ETHICS AND DISSEMINATION: This study was approved by the Medical Ethics Committee of the Erasmus Medical Center in Rotterdam, the Netherlands (registration number MEC-2022-0687). This ethical approval covers all study sites. Every significant amendment to the protocol will have to be approved by the medical ethics committee. The local feasibility was tested by the medical ethics committee and board of directors of all study sites included in the study. Written informed consent will be obtained from the patients and/or the legal representative(s) before enrolment in the study. Findings will be disseminated through publication in peer-reviewed journals and presentation at national and international conferences. Results will contribute to the evidence base for optimising olanzapine dosing in patients with AN. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Liang, Jiayi AU - Liang J AUID- ORCID: 0000-0001-5796-3412 AD - Department of Hospital Pharmacy, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands j.liang@erasmusmc.nl. AD - Rotterdam Clinical Pharmacometrics Group, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands. FAU - Dierckx, Bram AU - Dierckx B AD - Department of Child and Adolescent Psychiatry and Psychology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands. FAU - Dieleman, Gwen C AU - Dieleman GC AD - Department of Child and Adolescent Psychiatry and Psychology, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands. FAU - Bosch, Tessa M AU - Bosch TM AD - Department of Clinical Pharmacology & Toxicology, Maasstad Laboratory, Maasstad Hospital, Rotterdam, The Netherlands. AD - Department of Hospital Pharmacy, Maasstad Hospital, Rotterdam, The Netherlands. FAU - Koch, Birgit C P AU - Koch BCP AD - Department of Hospital Pharmacy, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands. AD - Rotterdam Clinical Pharmacometrics Group, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands. FAU - De Winter, Brenda C M AU - De Winter BCM AD - Department of Hospital Pharmacy, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands. AD - Rotterdam Clinical Pharmacometrics Group, Erasmus MC University Medical Center Rotterdam, Rotterdam, The Netherlands. LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260915 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - N7U69T4SZR (Olanzapine) RN - 0 (Antipsychotic Agents) SB - IM MH - Humans MH - *Olanzapine/pharmacokinetics/administration & dosage MH - *Anorexia Nervosa/drug therapy MH - Cross-Sectional Studies MH - Female MH - Adolescent MH - *Antipsychotic Agents/pharmacokinetics/administration & dosage/therapeutic use MH - Adult MH - Young Adult MH - Child MH - Male MH - Research Design PMC - PMC13583754 OTO - NOTNLM OT - Adolescent OT - Adolescents OT - Adult psychiatry OT - PSYCHIATRY OT - Pharmacists COIS- Competing interests: BD, BCPK and BCMDW have received grant research support from the Netherlands Organization for Health Research and Development (ZonMW). All other authors have no competing interest to declare. EDAT- 2026/09/15 23:35 MHDA- 2026/09/15 23:36 PMCR- 2026/09/15 CRDT- 2026/09/15 20:44 PHST- 2026/09/15 23:36 [medline] PHST- 2026/09/15 23:35 [pubmed] PHST- 2026/09/15 20:44 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - bmjopen-2026-119486 [pii] AID - 10.1136/bmjopen-2026-119486 [doi] PST - epublish SO - BMJ Open. 2026 Sep 15;16(9):e119486. doi: 10.1136/bmjopen-2026-119486. PMID- 42744207 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261023 IS - 1532-3064 (Electronic) IS - 0954-6111 (Linking) VI - 263 DP - 2026 Nov TI - Identification of modifiable risk factors to prevent atopic wheeze in infants born to mothers with asthma: a cohort study. PG - 109154 LID - S0954-6111(26)00523-8 [pii] LID - 10.1016/j.rmed.2026.109154 [doi] AB - OBJECTIVE: Maternal asthma is the leading risk factor for children developing wheeze and allergic disease in early life. We aimed to describe atopic phenotypes in infants of mothers with asthma and assess which early-life factors were associated with these phenotypes. METHODS: Participants were part of the Breathing for Life Trial Birth Cohort, which recruited pregnant women with asthma prior to 23 weeks gestation (n = 549). Parents completed a validated questionnaire about their child's wheeze requiring healthcare utilization (hospitalization, emergency department visits, consultant referral and primary care visits for wheeze, asthma medication use), respiratory infections, eczema and rhinitis at 12 months of age. Latent class analysis was used to identify the atopic phenotypes among infants. Logistic regression assessed early-life risk factors including maternal characteristics, perinatal factors and environmental exposures. RESULTS: Three phenotypes were identified: low-atopy/low-wheeze (35.2%), atopic mild-wheeze (38.6%) and atopic high-wheeze (26.2%). Maternal obesity (aOR 3.22 95% CI 1.90, 5.44), smoking in pregnancy (aOR 2.60 95%CI 1.36, 4.97), asthma exacerbations in pregnancy (aOR 1.98 95%CI 1.30, 3.02), preterm birth (aOR 2.50 1.34, 4.66), and NICU admission (aOR 2.71 95%CI 1.14, 6.46) were associated with atopic high-wheeze compared to low-atopy/low-wheeze. Maternal obesity (aOR 2.02 95%CI 1.26, 3.24) and smoking in pregnancy (aOR 2.55 95%CI 1.37, 4.72) were associated with atopic mild-wheeze compared to low-atopy/low-wheeze. CONCLUSION: Multiple modifiable factors (maternal obesity, smoking and maternal asthma exacerbations) and adverse birth outcomes are associated with the severity of wheeze in infants of mothers with asthma, providing an opportunity for intervention to prevent later childhood asthma. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Liu, Jihong AU - Liu J AD - Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. FAU - Brew, Bronwyn K AU - Brew BK AD - School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia. Electronic address: bronwyn.brew@newcastle.edu.au. FAU - Zhao, Xingpei AU - Zhao X AD - Arnold School of Public Health, University of South Carolina, Columbia, SC, USA. FAU - Collison, Adam AU - Collison A AD - School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia. FAU - Jensen, Megan E AU - Jensen ME AD - School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia. FAU - Mattes, Joerg AU - Mattes J AD - School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia; Department of Respiratory Medicine, John Hunter Children's Hospital, Newcastle, NSW, Australia. FAU - Robinson, Paul D AU - Robinson PD AD - Children's Health and Environment Program, Child Health Research Centre, University of Queensland, QLD, Australia; Department of Respiratory Medicine, Queensland Children's Hospital, QLD, Australia. FAU - Sly, Peter D AU - Sly PD AD - Children's Health and Environment Program, Child Health Research Centre, University of Queensland, QLD, Australia. FAU - Gibson, Peter G AU - Gibson PG AD - School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia; Department of Respiratory & Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia. FAU - Murphy, Vanessa E AU - Murphy VE AD - School of Medicine and Public Health, University of Newcastle, NSW, Australia; Asthma and Breathing Research Program, Hunter Medical Research Institute, Newcastle, NSW, Australia. LA - eng PT - Journal Article DEP - 20260915 PL - England TA - Respir Med JT - Respiratory medicine JID - 8908438 SB - IM MH - Humans MH - Female MH - *Asthma/complications/epidemiology MH - *Respiratory Sounds/etiology MH - Pregnancy MH - Risk Factors MH - Infant MH - Adult MH - *Prenatal Exposure Delayed Effects/prevention & control MH - Cohort Studies MH - Smoking/adverse effects MH - Infant, Newborn MH - Phenotype MH - *Pregnancy Complications/epidemiology MH - Male MH - Developmental Origins of Health and Disease MH - Mothers OTO - NOTNLM OT - Asthma OT - Infant OT - Maternal OT - Obesity OT - Phenotypes OT - Smoking OT - Wheeze COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Bronwyn Brew reports financial support was provided by National Health and Medical Research Council. Vanessa Murphy reports financial support was provided by Australian Government Medical Research Future Fund. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/15 23:35 MHDA- 2026/10/23 23:31 CRDT- 2026/09/15 19:21 PHST- 2026/03/19 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/09 00:00 [accepted] PHST- 2026/10/23 23:31 [medline] PHST- 2026/09/15 23:35 [pubmed] PHST- 2026/09/15 19:21 [entrez] AID - S0954-6111(26)00523-8 [pii] AID - 10.1016/j.rmed.2026.109154 [doi] PST - ppublish SO - Respir Med. 2026 Nov;263:109154. doi: 10.1016/j.rmed.2026.109154. Epub 2026 Sep 15. PMID- 42743207 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260917 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 9 DP - 2026 TI - Performance evaluation of a direct chemiluminescence assay for 25-hydroxyvitamin D and its application in assessing vitamin D status among reproductive-age women in southeastern China. PG - e0356809 LID - 10.1371/journal.pone.0356809 [doi] LID - e0356809 AB - BACKGROUND: Vitamin D deficiency is a global public health concern, and women of reproductive age represent a particularly vulnerable population. Accurate measurement of serum 25-hydroxyvitamin D [25(OH)D] is therefore essential for reliable clinical assessment. This study aimed to evaluate the analytical performance of the Innodx vitamin D assay for 25(OH)D measurement and to investigate the prevalence of vitamin D deficiency among women of reproductive age in southeastern China. METHODS: This cross-sectional study enrolled women of reproductive age (20-45 years) who sought medical services at Xiamen Maternal and Child Health Hospital in China between November 2023 and September 2025. Serum 25(OH)D levels were measured to determine vitamin D status using the Innodx vitamin D assay (Xiamen Innodx Biotech Co., Ltd., Xiamen, China). The analytical performance of the assay was validated according to Clinical and Laboratory Standards Institute (CLSI) guidelines, covering precision, accuracy, linearity, and interference. A method comparison was performed against liquid chromatography-tandem mass spectrometry (LC-MS/MS) and the Roche electrochemiluminescence assay. Based on the measured levels, vitamin D status was categorized as deficient (< 20 ng/mL), insufficient (>/=20, < 30 ng/mL), or sufficient (>/= 30 ng/mL). RESULTS: The intra-assay coefficients of variation (CV) were 3.18%, 2.09%, and 1.86% at three concentration levels (5, 25, and 100 ng/mL), while intermediate precision CVs were 4.34%, 3.64%, and 3.17%, respectively. Accuracy testing showed bias of 4.20% and 3.26% at 20 and 50 ng/mL. The assay demonstrated excellent linearity (R2 = 0.998) across the range of 4.0-150.0 ng/mL. No significant interference was observed from hemoglobin (100 mg/dL), bilirubin (40 mg/dL), triglycerides (400 mg/dL), or rheumatoid factor (600 IU/mL). In method comparison with LC-MS/MS, the Innodx vitamin D assay demonstrated strong concordance with a Pearson correlation coefficient of r = 0.970. When compared with the Roche vitamin D assay, the Innodx showed better correlation with LC-MS/MS. Among 495 women, the mean 25(OH)D concentration was 20.50 +/- 7.88 ng/mL, with 88.9% (95% CI: 86.1%, 91.7%) having vitamin D deficiency or insufficiency. Women aged 35 years: 23.72 +/- 8.56 ng/mL) (P < 0.05). CONCLUSION: The Innodx vitamin D chemiluminescence assay demonstrated satisfactory analytical performance for clinical use. Our findings reveal a high prevalence of vitamin D deficiency among reproductive-age women in southeastern China, particularly in younger age groups, highlighting the need for public health interventions. CI - Copyright: (c) 2026 Zhu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Zhu, Min AU - Zhu M AD - Department of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. FAU - Chen, Tianhua AU - Chen T AD - Department of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. FAU - Cao, Jiali AU - Cao J AUID- ORCID: 0000-0002-6286-5574 AD - Department of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. FAU - Luo, Linhua AU - Luo L AD - Department of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. FAU - Lin, Minchuan AU - Lin M AD - Department of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. FAU - Huang, Haiying AU - Huang H AD - Department of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. FAU - Xu, Weiwei AU - Xu W AD - Medical Laboratory of Xiamen Humanity Hospital Fujian Medical University, Xiamen, China. FAU - Li, Lihua AU - Li L AD - Xiamen Innodx Biotech Co., Ltd, Xiamen, China. FAU - Xie, Hongbin AU - Xie H AD - Department of Health Management, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. FAU - Chen, Xiaoli AU - Chen X AD - Department of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. FAU - Ye, Huiming AU - Ye H AUID- ORCID: 0000-0003-2069-3644 AD - Department of Laboratory Medicine, Fujian Key Clinical Specialty of Laboratory Medicine, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China. LA - eng PT - Journal Article DEP - 20260915 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Humans MH - Female MH - *Vitamin D/analogs & derivatives/blood MH - Adult MH - China/epidemiology MH - *Vitamin D Deficiency/blood/epidemiology/diagnosis MH - Middle Aged MH - *Luminescent Measurements/methods MH - Cross-Sectional Studies MH - Young Adult MH - Tandem Mass Spectrometry PMC - PMC13577506 COIS- Lihua Li is employed by Xiamen Innodx Biotech Co., Ltd. Xiamen Innodx Biotech Co., Ltd. provided support in the form of salary for author Lihua Li. This does not alter our adherence to PLOS ONE policies on sharing data and materials. The other authors declare no competing interests. EDAT- 2026/09/15 18:07 MHDA- 2026/09/15 18:08 PMCR- 2026/09/15 CRDT- 2026/09/15 13:53 PHST- 2026/04/14 00:00 [received] PHST- 2026/08/07 00:00 [accepted] PHST- 2026/09/15 18:08 [medline] PHST- 2026/09/15 18:07 [pubmed] PHST- 2026/09/15 13:53 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - PONE-D-26-17612 [pii] AID - 10.1371/journal.pone.0356809 [doi] PST - epublish SO - PLoS One. 2026 Sep 15;21(9):e0356809. doi: 10.1371/journal.pone.0356809. eCollection 2026. PMID- 42740930 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260923 IS - 3086-3910 (Electronic) IS - 3086-3910 (Linking) VI - 52 IP - 3 DP - 2026 TI - Targeted metabolomic analysis of exhaled breath condensate before and after bronchial provocation by eucapnic voluntary hyperventilation in adolescents with asthma: an exploratory study. PG - e20250375 LID - 10.36416/1806-3756/e20250375 [doi] LID - e20250375 AB - OBJECTIVE: To analyze endogenous metabolites in exhaled breath condensate before and after eucapnic voluntary hyperventilation (EVH) in adolescents with asthma with and without exercise-induced bronchoconstriction (EIB). METHODS: This was an exploratory study including 44 adolescents with asthma in the 10- to 20-year age bracket. They were divided into two groups: the group of patients with EIB (n = 25) and that of those without (n = 19). EIB was defined as a >/= 10% reduction in FEV(1) after a six-minute EVH challenge using 5% carbon dioxide. Ventilation was maintained at 21 times the baseline FEV(1). Exhaled breath condensate was collected before EVH and 15-30 min after EVH by using a validated device. Samples were analyzed by proton nuclear magnetic resonance focusing on the region of d1.60-2.00 parts per million. Data were preprocessed by using sum normalization and autoscaling for orthogonal partial least squares discriminant analysis. RESULTS: All participants completed the protocol without adverse events. The mean reduction in FEV(1) was significantly greater in the group of patients with EIB than in that of those without (-25.13% vs. -4.37%; mean difference, -20.76%; 95% CI, -26.45 to -15.07). In the EIB group, responses were classified as mild (n = 15), moderate (n = 9), or severe (n = 1). Post-EVH orthogonal partial least squares discriminant analysis showed significant separation between pre- and post-EVH metabolic profiles in the group of patients with EIB (p < 0.001) but not in that of those without (p = 0.195). The discriminative response in patients with EIB was associated with a marked increase in acetate signal intensity at 1.76 parts per million. CONCLUSIONS: Adolescents with EIB show a distinct metabolic fingerprint that is significantly associated with ventilatory stress. Acetate emerged as a key metabolic differentiator, suggesting a specific biochemical pathway associated with the exercise response and supporting its potential role in precision phenotyping of EIB. CI - (c) 2026 Sociedade Brasileira de Pneumologia e Tisiologia. FAU - de Albuquerque, Claudio Goncalves AU - de Albuquerque CG AUID- ORCID: 0000-0002-1698-7853 AD - . Universidade Federal de Pernambuco, Recife (PE) Brasil. FAU - Rizzo, Jose Angelo AU - Rizzo JA AUID- ORCID: 0000-0002-6876-3122 AD - . Universidade Federal de Pernambuco, Recife (PE) Brasil. FAU - Rodrigues, Edil de Albuquerque AU - Rodrigues EA AUID- ORCID: 0000-0001-6203-3658 AD - . Universidade Federal de Pernambuco, Recife (PE) Brasil. FAU - Silva, Ricardo Oliveira AU - Silva RO AUID- ORCID: 0000-0001-8090-7320 AD - . Laboratorio de Metabonomica e Quimiometria. Departamento de Quimica Fundamental, Universidade Federal de Pernambuco, Recife (PE) Brasil. FAU - da Luz, Tatiane Priscila Santos Rodrigues AU - da Luz TPSR AUID- ORCID: 0000-0002-8394-5012 AD - . Universidade Federal de Pernambuco, Recife (PE) Brasil. FAU - Correia, Marco Aurelio de Valois AU - Correia MAV AUID- ORCID: 0000-0003-0386-5256 AD - . Programa de Pos-Graduacao em Hebiatria e Programa de Pos-Graduacao Associado em Educacao Fisica, Faculdade de Ciencias Medicas, Universidade Federal de Pernambuco, Recife (PE) Brasil. FAU - Peixoto, Decio Medeiros AU - Peixoto DM AUID- ORCID: 0000-0003-1779-5762 AD - . Universidade Federal de Pernambuco, Recife (PE) Brasil. LA - eng PT - Journal Article DEP - 20260813 PL - Brazil TA - Respir Res Clin Pract JT - Respiratory research & clinical practice JID - 9919269228506676 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Hyperventilation/metabolism/physiopathology/diagnosis MH - Male MH - Breath Tests/methods MH - *Metabolomics/methods MH - *Asthma/metabolism/diagnosis/physiopathology MH - *Bronchial Provocation Tests/methods MH - Child MH - *Exhalation/physiology MH - Young Adult MH - *Asthma, Exercise-Induced/metabolism/diagnosis/physiopathology PMC - PMC13568813 OTO - NOTNLM OT - Asthma OT - Breath tests OT - Exercise-induced bronchospasm OT - Metabolomics EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 12:08 PMCR- 2026/08/13 CRDT- 2026/09/15 05:01 PHST- 2025/09/18 00:00 [received] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/09/15 12:08 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 05:01 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - 10.36416/1806-3756/e20250375 [doi] PST - epublish SO - Respir Res Clin Pract. 2026 Aug 13;52(3):e20250375. doi: 10.36416/1806-3756/e20250375. eCollection 2026. PMID- 42740390 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260917 IS - 2314-6753 (Electronic) IS - 2314-6745 (Print) VI - 2026 IP - 1 DP - 2026 TI - Olfactory Performance of Children and Adolescents With Type 1 Diabetes: Relationship to Diabetes Duration and Glycemic Control. PG - e8415282 LID - 10.1155/jdr/8415282 [doi] LID - 8415282 AB - BACKGROUND/OBJECTIVES: Olfactory dysfunction is increasingly recognized as a complication of diabetes that negatively impacts eating behavior and quality of life. This study investigates olfactory function in adolescents with Type 1 diabetes and evaluates the impact of disease duration and long-term glycemic control (mean HbA1c) on olfactory performance. METHODS: Olfactory function was assessed using the validated "Sniffin' Sticks" test, which evaluates odor threshold, discrimination, and identification to generate a composite TDI score for diagnosing hyposmia (TDI < 30.75). RESULTS: Hyposmia was identified in 30% of adolescents with Type 1 diabetes, whereas none exhibited anosmia. Overall olfactory performance (TDI scores) did not differ significantly by diabetes duration, age, sex, BMI, lipid profiles, or insulin therapy method. However, a strong negative correlation was observed between long-term mean HbA1c and total TDI scores (r = -0.65, p < 0.001). Logistic regression confirmed that elevated mean HbA1c (> 7.0%) was a significant independent predictor of olfactory impairment, increasing the risk of hyposmia 3.7-fold (OR = 3.726, p = 0.018). CONCLUSIONS: Poor long-term glycemic control significantly impairs olfactory function in adolescents with Type 1 diabetes. This is demonstrated by the marked reduction in olfactory scores among adolescents with high mean HbA1c. Consequently, future research may validate olfactory testing as an effective, early biomarker for diabetic complications. CI - Copyright (c) 2026 Grzegorz Sobek et al. Journal of Diabetes Research published by John Wiley & Sons Ltd. FAU - Sobek, Grzegorz AU - Sobek G AUID- ORCID: 0000-0003-2504-0562 AD - Faculty of Health Sciences and Psychology, Collegium Medicum, University of Rzeszow, Rzeszow, Poland, ur.edu.pl. AD - University Center for Research and Development in Health Sciences, Rzeszow, Poland. FAU - Jagielski, Pawel AU - Jagielski P AUID- ORCID: 0000-0001-7583-8965 AD - Department of Nutrition and Drug Research, Institute of Public Health, Faculty of Health Sciences, Jagiellonian University Medical College, Krakow, Poland, cm-uj.krakow.pl. FAU - Mazur, Artur AU - Mazur A AUID- ORCID: 0000-0001-5393-3515 AD - Institute of Medical Sciences, Medical College of Rzeszow University, Rzeszow, Poland. LA - eng PT - Journal Article PL - United States TA - J Diabetes Res JT - Journal of diabetes research JID - 101605237 RN - 0 (Glycated Hemoglobin) RN - 0 (Blood Glucose) RN - 0 (hemoglobin A1c protein, human) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/blood/complications/physiopathology/drug therapy MH - Adolescent MH - Male MH - Female MH - *Glycemic Control MH - Glycated Hemoglobin/metabolism/analysis MH - Child MH - *Olfaction Disorders/etiology/physiopathology/diagnosis MH - *Blood Glucose/metabolism MH - *Smell/physiology MH - *Anosmia/etiology/physiopathology/diagnosis MH - Time Factors MH - Quality of Life PMC - PMC13575325 OTO - NOTNLM OT - Type 1 diabetes OT - adolescents OT - glycated hemoglobin OT - olfactory function COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 11:37 PMCR- 2026/09/14 CRDT- 2026/09/15 03:31 PHST- 2026/08/24 00:00 [revised] PHST- 2026/05/29 00:00 [received] PHST- 2026/08/29 00:00 [accepted] PHST- 2026/09/15 11:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:31 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - JDR8415282 [pii] AID - 10.1155/jdr/8415282 [doi] PST - ppublish SO - J Diabetes Res. 2026;2026(1):e8415282. doi: 10.1155/jdr/8415282. PMID- 42740054 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 17 DP - 2026 Aug 27 TI - Activation Duty Cycle and Regional Muscle Co-Activation Across GMFCS Levels in Ambulatory Children with Spastic Cerebral Palsy: An Exploratory Surface EMG Study. LID - 10.3390/s26175434 [doi] LID - 5434 AB - During self-selected overground walking, we examined participant-level surface electromyography (sEMG) descriptors associated with Gross Motor Function Classification System (GMFCS) levels I-III in 38 ambulatory children with spastic cerebral palsy. Eight-muscle sEMG was summarized using a design-locked pool of 16 peak-normalized envelope and exploratory synergy features. Higher GMFCS level was associated most consistently with longer activation duty cycle, stronger distal and proximal peak-normalized co-activation, and greater inter-muscle spatial entropy. Directions were retained across sensitivity analyses. For secondary within-cohort discrimination, the 16-feature pool yielded a quadratic weighted kappa (QWK) of 0.837+/-0.046 across 50 repeated participant-level nested cross-validation evaluations. Repeating correlation reduction and four-feature selection inside every outer-training fold yielded QWK 0.849+/-0.029. Both estimates reuse the 38 children and describe resampling performance, not independent-population generalizability. The core-four specification was post hoc. In an open supplementary workbook containing 195 unique participant IDs, directional concordance was strongest for activation duty cycle and distal co-activation, but direct transfer of the internally fitted 16-feature and core-four models was poor (QWK 0.210 and 0.077). Without healthy controls or measured walking speed and stride length, these cross-sectional results identify descriptors associated with ambulatory GMFCS level, not cerebral-palsy-specific biomarkers or evidence of clinical predictive utility. FAU - Huang, Peng AU - Huang P AUID- ORCID: 0009-0000-6053-0626 AD - School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 101408, China. FAU - Zhang, Zhen AU - Zhang Z AUID- ORCID: 0000-0002-2014-5747 AD - School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 101408, China. FAU - Tong, Yonggang AU - Tong Y AUID- ORCID: 0000-0002-7516-8313 AD - School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 101408, China. FAU - Sun, Yingfei AU - Sun Y AUID- ORCID: 0000-0003-0615-2569 AD - School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 101408, China. LA - eng GR - 61431017/National Natural Science Foundation of China/ PT - Journal Article DEP - 20260827 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology MH - *Electromyography/methods MH - Child MH - Female MH - Male MH - *Muscle, Skeletal/physiopathology MH - Walking/physiology MH - Adolescent PMC - PMC13568141 OTO - NOTNLM OT - GMFCS OT - activation duty cycle OT - cerebral palsy OT - feature association OT - interpretable machine learning OT - muscle co-activation OT - surface electromyography COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 11:37 PMCR- 2026/08/27 CRDT- 2026/09/15 03:25 PHST- 2026/07/29 00:00 [received] PHST- 2026/08/26 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/15 11:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:25 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - s26175434 [pii] AID - sensors-26-05434 [pii] AID - 10.3390/s26175434 [doi] PST - epublish SO - Sensors (Basel). 2026 Aug 27;26(17):5434. doi: 10.3390/s26175434. PMID- 42739246 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260915 LR - 20260916 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 16 IP - 17 DP - 2026 Sep 1 TI - Comparison of Ultrasound and Scintigraphy in Gastric Emptying: A Comprehensive Review. LID - 10.3390/diagnostics16172816 [doi] LID - 2816 AB - Gastric emptying is the process by which gastric contents are transferred from the stomach to the small intestine for further digestion and nutrient absorption. It is the result of multiple gastrointestinal mechanisms and is essential for understanding the kinetics of digestion in humans. Delayed gastric emptying is clinically relevant as it is commonly observed in conditions such as gastroparesis and functional dyspepsia. A wide range of diagnostic modalities are available to assess gastric emptying, including scintigraphy, ultrasonography, magnetic resonance imaging, gastric aspiration, and stable isotope breath tests. Scintigraphy is widely regarded as the 'gold standard' technique, as it enables a direct quantitative assessment of gastric emptying following ingestion of a radiolabeled meal(s). Scintigraphy is non-invasive, reproducible, widely available, and well tolerated; however, it lacks standardized protocols, is time-consuming, costly, and necessitates exposure to ionizing radiation. Although the radiation dose is low, cumulative exposure remains a concern, particularly in pediatric and pregnant populations. In contrast, ultrasonography is safe, non-invasive, portable, inexpensive, and free from radiation exposure. Nevertheless, the application of ultrasound is limited by operator dependency and the need for technical expertise, and image quality may be affected by factors such as obesity and intraluminal gas. Furthermore, there is substantial methodological variability across studies, and its use in assessing gastric emptying of semisolid and solid meals is less well established. 3D ultrasonography, in particular, shows promise as a safe, non-invasive method for assessing gastric emptying. Further studies are required to promote the consistent application of established scintigraphic gastric emptying protocols across centers and to validate 3D ultrasound, particularly with solid meals, to potentially enhance its role as an alternative to scintigraphy. This article represents a comprehensive review based on a structured literature search with the primary aim of comparing ultrasonographic and scintigraphic measurements of gastric emptying, including the advantages and disadvantages of both methods. FAU - Lein, Emilie AU - Lein E AD - Department of Clinical Medicine, University of Bergen, 5007 Bergen, Norway. FAU - Jones, Karen L AU - Jones KL AUID- ORCID: 0000-0002-1155-5816 AD - School of Medicine, Adelaide University, Adelaide 5005, Australia. AD - School of Allied Health and Human Performance, Adelaide University, Adelaide 5005, Australia. AD - Endocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide 5000, Australia. FAU - Gilja, Odd Helge AU - Gilja OH AUID- ORCID: 0000-0002-0436-0383 AD - Department of Clinical Medicine, University of Bergen, 5007 Bergen, Norway. AD - National Centre for Ultrasound in Gastroenterology, Department of Medicine, Haukeland University Hospital, 5021 Bergen, Norway. LA - eng PT - Journal Article PT - Review DEP - 20260901 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC13565500 OTO - NOTNLM OT - gastric emptying OT - gastric function OT - scintigraphy OT - stomach OT - ultrasound COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/01 CRDT- 2026/09/15 03:24 PHST- 2026/06/11 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:24 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - diagnostics16172816 [pii] AID - diagnostics-16-02816 [pii] AID - 10.3390/diagnostics16172816 [doi] PST - epublish SO - Diagnostics (Basel). 2026 Sep 1;16(17):2816. doi: 10.3390/diagnostics16172816. PMID- 42739090 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Sep 6 TI - Maternal Consumption of Fruits, Vegetables and Fruit Juices in Relation to Offspring Weight at 4 Years. LID - 10.3390/nu18172918 [doi] LID - 2918 AB - Background/Objectives: Maternal diet plays a crucial role in fetal development and may influence offspring weight development. Although fruits and vegetables provide nutritional and metabolic benefits during pregnancy, evidence regarding their specific role on childhood overweight/obesity remains limited. This study aimed to examine the association between maternal intake of fruits, vegetables, and fruit juices during pregnancy and the risk of overweight/obesity in children at 4 years of age. Methods: We analyzed 252 mother-child pairs from the Mediterranean ECLIPSES cohort in a prospective observational study. Maternal dietary intake was assessed at 12, 24 and 36 weeks of gestation using a semiquantitative food frequency questionnaire previously validated in a Spanish population. Childhood overweight/obesity was defined as a BMI z-score above the 85th percentile for age and sex at age 4. Multivariable-adjusted logistic regression models estimated ORs and 95% CIs. Results: Higher maternal consumption of fruits and vegetables was inversely associated with overweight/obesity in children (OR: 0.31 [0.13-0.74]). No associations were observed for total or natural fruit juice, whereas higher consumption of commercial fruit juice was associated with increased odds of overweight/obesity (OR: 2.48 [1.06-5.78]). Conclusions: Higher maternal combined consumption of fruits and vegetables during pregnancy was associated with lower odds of overweight or obesity in offspring at 4 years of age, whereas the opposite association was observed for commercial, but not natural, fruit juice. These associations may involve both prenatal biological and postnatal behavioral and family dietary pathways; however, the commercial fruit juice finding should be considered exploratory and requires confirmation in larger prospective studies. FAU - Riggioni-Saborio, Lucia AU - Riggioni-Saborio L AUID- ORCID: 0009-0004-9880-7159 AD - Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Departament de Ciencies Mediques Basiques, Universitat Rovira i Virgili, 43201 Reus, Spain. FAU - Jardi, Cristina AU - Jardi C AUID- ORCID: 0000-0002-7946-1488 AD - Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Departament de Ciencies Mediques Basiques, Universitat Rovira i Virgili, 43201 Reus, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRB CatSud), 43005 Tarragona, Spain. FAU - Becerra-Tomas, Nerea AU - Becerra-Tomas N AD - Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Departament de Ciencies Mediques Basiques, Universitat Rovira i Virgili, 43201 Reus, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRB CatSud), 43005 Tarragona, Spain. FAU - Cruz-Rodriguez, Josue AU - Cruz-Rodriguez J AUID- ORCID: 0000-0001-7145-5836 AD - Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Departament de Ciencies Mediques Basiques, Universitat Rovira i Virgili, 43201 Reus, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRB CatSud), 43005 Tarragona, Spain. FAU - Arija, Victoria AU - Arija V AUID- ORCID: 0000-0002-1758-0975 AD - Nutrition and Mental Health (NUTRISAM) Research Group, Unitat de Salut Publica i Epidemiologia Nutricional, Departament de Ciencies Mediques Basiques, Universitat Rovira i Virgili, 43201 Reus, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRB CatSud), 43005 Tarragona, Spain. AD - Collaborative Group on Lifestyles, Nutrition, and Tobacco (CENIT), Institut D'Investigacio en Atencio Primaria IDIAP Jordi Gol, 08007 Barcelona, Spain. LA - eng GR - PI12/02777/Institute of Health Carlos III/ GR - PI17/01754/Instituto de Salud Carlos III/ GR - European Union/ PT - Journal Article PT - Observational Study DEP - 20260906 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Fruit MH - *Vegetables MH - Female MH - *Fruit and Vegetable Juices MH - Pregnancy MH - Child, Preschool MH - Prospective Studies MH - *Maternal Nutritional Physiological Phenomena MH - Spain/epidemiology MH - *Pediatric Obesity/epidemiology/prevention & control/etiology MH - Male MH - Adult MH - Developmental Origins of Health and Disease MH - *Diet PMC - PMC13567673 OTO - NOTNLM OT - childhood obesity OT - fruit consumption OT - fruit juice consumption OT - maternal nutrition OT - pregnancy OT - vegetable consumption COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 11:37 PMCR- 2026/09/06 CRDT- 2026/09/15 03:24 PHST- 2026/07/20 00:00 [received] PHST- 2026/09/03 00:00 [revised] PHST- 2026/09/04 00:00 [accepted] PHST- 2026/09/15 11:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:24 [entrez] PHST- 2026/09/06 00:00 [pmc-release] AID - nu18172918 [pii] AID - nutrients-18-02918 [pii] AID - 10.3390/nu18172918 [doi] PST - epublish SO - Nutrients. 2026 Sep 6;18(17):2918. doi: 10.3390/nu18172918. PMID- 42739088 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Sep 5 TI - Associations of Diabetes-Related Distress, Disordered-Eating Risk, and Self-Perceived Health with Glycemic Outcomes in Adolescents with Type 1 Diabetes: An Exploratory Cross-Sectional Study. LID - 10.3390/nu18172916 [doi] LID - 2916 AB - Background/Objectives: Adolescents with type 1 diabetes mellitus (T1DM) are particularly vulnerable to psychological distress, disordered-eating (DE) risk and negative self-perceived health status (SPHS), which may compromise metabolic control and self-care. Although these factors have been studied individually, the usefulness of brief and clinically feasible screening tools to detect these dimensions remains underexplored. This study aimed to: (1) examine associations between distress, DE risk and SPHS; (2) explore their relationships with glycemic control, clinical profile and self-care; and (3) assess the influence of age and diabetes duration on these outcomes. Methods: A cross-sectional study was conducted in 37 adolescents with T1DM in Spain. Sociodemographic, anthropometric and clinical variables were obtained from medical records. Distress, DE risk and self-care were assessed using validated questionnaires, while SPHS was measured using single-item question. Pearson and Spearman correlations were performed. Results: Distress was present in 48.6% of participants and DE risk in 29.7%, while 67.6% reported positive SPHS. Distress correlated with higher HbA1c and lower TIR. DE risk correlated with BMI. Lower SPHS was associated with higher HbA1c. Age and diabetes duration were associated with greater glycemic variability, and diabetes duration also correlated with higher glucose and TyG-based insulin resistance indexes. No significant associations were found for self-care behaviors. Conclusions: Distress, DE risk and SPHS, assessed through feasible screening tools, showed meaningful associations with metabolic outcomes in adolescents with T1DM. Integrating brief psychological screening tools into routine care may facilitate early identification of psychological vulnerability profiles in this population during routine practice. FAU - Garcia-Poblet, Marta AU - Garcia-Poblet M AUID- ORCID: 0000-0001-7110-6222 AD - Nursing Department, Faculty of Health Science, University of Alicante, 03692 Alicante, Spain. AD - Research Group on Applied Dietetics, Nutrition and Body Composition (DANuC), University of Alicante, 03692 Alicante, Spain. FAU - Sospedra, Isabel AU - Sospedra I AUID- ORCID: 0000-0002-8513-8986 AD - Nursing Department, Faculty of Health Science, University of Alicante, 03692 Alicante, Spain. AD - Research Group on Applied Dietetics, Nutrition and Body Composition (DANuC), University of Alicante, 03692 Alicante, Spain. FAU - Formilan, Brisa Florencia AU - Formilan BF AD - Nursing Department, Faculty of Health Science, University of Alicante, 03692 Alicante, Spain. FAU - Soler-Climent, Esther AU - Soler-Climent E AUID- ORCID: 0000-0002-8543-4865 AD - Research and Innovation Area, Health Department of General Hospital of Elche, 03203 Elche, Alicante, Spain. AD - Traumatology and Neurosurgery Service, General Hospital of Elche, 03203 Elche, Alicante, Spain. FAU - Alberola-Chazarra, Manuel Antonio AU - Alberola-Chazarra MA AD - Pediatrics Unit, General Hospital of Elche, 03203 Elche, Alicante, Spain. FAU - Martinez-Sanz, Jose Miguel AU - Martinez-Sanz JM AUID- ORCID: 0000-0001-9054-3858 AD - Nursing Department, Faculty of Health Science, University of Alicante, 03692 Alicante, Spain. AD - Research Group on Applied Dietetics, Nutrition and Body Composition (DANuC), University of Alicante, 03692 Alicante, Spain. LA - eng PT - Journal Article DEP - 20260905 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Blood Glucose) RN - 0 (Glycated Hemoglobin) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/psychology/blood/complications MH - Adolescent MH - Cross-Sectional Studies MH - Female MH - Male MH - *Feeding and Eating Disorders/psychology/epidemiology MH - *Psychological Distress MH - *Self Concept MH - Self Care MH - Blood Glucose/metabolism MH - *Stress, Psychological MH - Risk Factors MH - Glycated Hemoglobin MH - Glycemic Control/psychology MH - Health Status MH - Spain MH - Surveys and Questionnaires PMC - PMC13567549 OTO - NOTNLM OT - adolescents OT - eating disorders OT - metabolic control OT - psychological distress OT - self-perceived health OT - type 1 diabetes mellitus COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 11:37 PMCR- 2026/09/05 CRDT- 2026/09/15 03:24 PHST- 2026/07/04 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/28 00:00 [accepted] PHST- 2026/09/15 11:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:24 [entrez] PHST- 2026/09/05 00:00 [pmc-release] AID - nu18172916 [pii] AID - nutrients-18-02916 [pii] AID - 10.3390/nu18172916 [doi] PST - epublish SO - Nutrients. 2026 Sep 5;18(17):2916. doi: 10.3390/nu18172916. PMID- 42739061 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Sep 3 TI - Food Allergies and Eating Disorders: An Exploration of Screening Prevalence and Associated Factors Among Adults. LID - 10.3390/nu18172890 [doi] LID - 2890 AB - Background/Objectives: Food allergy (FA) affects up to 10% of adults and requires ongoing dietary vigilance that may increase vulnerability to eating disorders (EDs), yet evidence in adults remains limited. This study compared ED screening and history between adults with and without food allergy (FA), and explored factors associated with positive screening among those with FA. Methods: This cross-sectional study recruited 371 adults (134 with FA, 237 without) via an online survey. Positive screening required meeting thresholds on both the Eating Attitudes Test-8 (EAT-8) and the Sick, Control, One, Fat, Food (SCOFF); ED history and treatment were assessed via self-report. Group differences were examined using chi-square tests and, for the primary comparison, age- and sex-adjusted logistic regression. Among those with FA, correlations identified candidate predictors of positive screening, which were entered into a further logistic regression. Results: FA status was not associated with positive screening for an ED (37.3% vs. 37.1%; p = 0.972), including after adjusting for age and sex. FA was significantly associated with a greater lifetime history of EDs (36.4% vs. 20.7%; p = 0.001) and ED treatment (17.9% vs. 10.1%; p = 0.032). Among those with FA, positive screening was independently predicted by ED history and shorter allergy duration in a multivariable model (Nagelkerke R(2) = 0.14); however, allergy duration and age were highly correlated, so this effect could not be shown to be independent of age. Conclusions: FA alone was not statistically associated with current positive screening but was linked to lifetime history and treatment, suggesting that this relationship may be more evident earlier in the FA experience. ED history and shorter allergy duration were associated with positive screening among those with FA, though the duration effect may partly reflect age; sex was linked to screening only at the bivariate level, given too few male positive cases to model. Findings are preliminary, given the FA-unvalidated screening tools used, warranting longitudinal validated research. FAU - Hine, Jessica AU - Hine J AD - School of Psychology, University of Surrey, Guildford GU2 7XH, UK. AD - Surrey & Borders Partnership NHS Trust, Leatherhead KT22 7AD, UK. FAU - Andresen, Kirsty AU - Andresen K AUID- ORCID: 0000-0002-5483-6482 AD - Department of Non-Communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London WC1E 7HT, UK. FAU - Satherley, Rose-Marie AU - Satherley RM AUID- ORCID: 0000-0002-7535-2292 AD - School of Psychology, University of Surrey, Guildford GU2 7XH, UK. FAU - Jones, Christina J AU - Jones CJ AUID- ORCID: 0000-0003-3672-6631 AD - School of Psychology, University of Surrey, Guildford GU2 7XH, UK. LA - eng PT - Journal Article DEP - 20260903 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - *Food Hypersensitivity/epidemiology/diagnosis MH - Male MH - Adult MH - Cross-Sectional Studies MH - *Feeding and Eating Disorders/epidemiology/diagnosis MH - Prevalence MH - Middle Aged MH - Young Adult MH - Logistic Models MH - Risk Factors MH - Adolescent MH - Mass Screening MH - Surveys and Questionnaires PMC - PMC13567571 OTO - NOTNLM OT - adults OT - disordered eating OT - eating disorders OT - food allergy OT - prevalence OT - screening COIS- R.-M.S.: Research funding from the National Institute for Health and Care Research (NIHR) and Coeliac UK. Honoraria from Dr Schar and My NutriWeb. C.J.J.: Research funding from the NIHR, Innovate UK, Food Standards Agency, Aimmune, the National Peanut Board, and Novartis. Honoraria from the NIHR, Nutricia, Mead Johnson, DBV Technologies, Allergy UK, The Milk Allergy Dietitian, and Siemens Healthineers. Member of the Allergy UK Health Advisory Board, British Society for Allergy & Clinical Immunology Psychology Special Interest Group (SIG), and the British Psychological Society Paediatric Allergy SIG. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/03 CRDT- 2026/09/15 03:24 PHST- 2026/07/28 00:00 [received] PHST- 2026/08/28 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:24 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - nu18172890 [pii] AID - nutrients-18-02890 [pii] AID - 10.3390/nu18172890 [doi] PST - epublish SO - Nutrients. 2026 Sep 3;18(17):2890. doi: 10.3390/nu18172890. PMID- 42739059 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Sep 3 TI - Assessment of Nutritional Risk Representations in Publicly Available Data in Saudi Arabia: A Triangulated Scoping Study. LID - 10.3390/nu18172888 [doi] LID - 2888 AB - Background: Saudi Arabia maintains official statistics on its food security, in addition to conducting surveys on health parameters and performing national health assessments. Also, several academic papers on dietary patterns are published every year. Many published documents analyze data on food availability, self-reported eating habits, and biomarker-based health risks. However, individually, they represent distinct aspects of nutrition. Hence, this study was undertaken to examine publicly accessible nutrition-related evidence in Saudi Arabia and assess whether existing public food and nutrition datasets consistently align with the biological indicators of nutritional risk. Methods: Searches were conducted using defined criteria in publicly available Saudi and international sources published or updated between 2005 and 2025. These were identified through official reports, global food databases, WHO-aligned surveys, and peer-reviewed articles, with searches conducted and updated during June-July 2026. Sources were classified by representativeness, recency, measurement validity, accessibility, and analytical role. The primary outcome was the completeness and interpretability of public evidence streams rather than a pooled prevalence estimate. Results: SHIS 2013 remains the top public national dietary intake dataset, which shows that only 5.2% and 7.5% of people met their fruit and vegetable intake recommendations, respectively. GASTAT Health Determinants Statistics 2024 indicated that only 10.2% of people aged 15 years and above ate five or more portions of fruits and vegetables daily, yet GASTAT Food Security Statistics 2024 indicated significant per capita availability of rice, milk, poultry, eggs, red meat, onions, tomatoes, and dates. High levels of biological risk were evident in WHS 2019 biomarkers; for example, 42.6% of people had hypercholesterolemia and 50% had low hemoglobin according to the WHS 2019 indicator definition. Recent studies provided additional data on beverages, sugars, dietary habits of adolescents, and diet quality but lacked national food-wide intake data. Conclusions: Public Saudi nutrition data provide complementary but non-equivalent information; indicators show low dietary adequacy and high biomarker-defined risk, supporting the need for integrated individual-level nutrition surveillance. In the future, Saudi national nutrition surveillance must focus on individual-level intake data and biomarker-based measurements. FAU - Alagal, Reham I AU - Alagal RI AUID- ORCID: 0000-0002-8515-1574 AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260903 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) SB - IM MH - Saudi Arabia/epidemiology MH - Humans MH - *Diet/statistics & numerical data MH - *Nutritional Status MH - Vegetables MH - Fruit MH - Feeding Behavior MH - Risk Assessment MH - Adolescent MH - Biomarkers MH - Female PMC - PMC13567205 OTO - NOTNLM OT - Saudi Arabia OT - biomarkers OT - dietary consumption OT - food availability OT - food balance sheets OT - fruit and vegetable consumption OT - hypercholesterolaemia OT - low haemoglobin OT - nutrition surveillance COIS- The author declares no conflict of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/03 CRDT- 2026/09/15 03:24 PHST- 2026/07/05 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:24 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - nu18172888 [pii] AID - nutrients-18-02888 [pii] AID - 10.3390/nu18172888 [doi] PST - epublish SO - Nutrients. 2026 Sep 3;18(17):2888. doi: 10.3390/nu18172888. PMID- 42739031 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Sep 1 TI - A Comprehensive Study of Dietary and Lifestyle Correlates of Erythrocyte Membrane Fatty Acids and Oxidative Stress and Their Association with Maternal and Neonatal Outcomes. LID - 10.3390/nu18172859 [doi] LID - 2859 AB - Background: Erythrocyte fatty acid (FA) and oxidative stress levels are influenced by a range of factors. The aim of this study was to evaluate erythrocyte FA profiles and oxidative stress markers and their relationships with each other, nutrition, lifestyle, gestational age, and pregnancy outcomes in pregnant Latvian women. Methods: A total of 74 pregnant and postpartum women were cross-sectionally examined. Dietary intake was assessed using a validated food frequency questionnaire; erythrocyte FA composition was analyzed using gas chromatography with a flame ionization detector; and oxidative status was assessed based on Ferric Reducing Antioxidant Power (FRAP) assays, glutathione peroxidase (GPx) activity, and selenoprotein P (SEPP1) and malondialdehyde (MDA) levels. Results: Dietary fats constituted 42.0% of the total caloric intake. Saturated fatty acids (SFAs) predominated in erythrocytes (55.7%), with the highest concentration observed for 16:0. Although multiple significant correlations between dietary factors and laboratory parameters were identified, none remained significant after correction for multiple comparisons. Erythrocyte 18:3, n-3 was significantly associated with FRAP (p < 0.05). Gestational complications and age did not affect biochemical parameters (p > 0.05), though gestational age correlated with MDA (r = 0.377, p < 0.05) and pre-pregnancy body mass index (BMI) with MUFAs (r = 0.373, p < 0.01). The FA composition differed depending on smoking status and alcohol consumption. Conclusions: Given the exploratory nature of this study, findings should be interpreted with appropriate caution. Several associations retained statistical significance following correction for multiple comparisons, namely between erythrocyte 18:3, n-3 and FRAP, alcohol consumption and smoking with erythrocyte fatty acid profiles, maternal age and plasma MDA concentrations, and pre-gestational BMI and MUFA levels. The remaining associations did not withstand correction and should therefore be regarded as hypothesis-generating, warranting confirmation in larger, adequately powered, confirmatory studies. FAU - Nikolajeva, Ksenija AU - Nikolajeva K AD - Riga East Clinical University Hospital, 2 Hipokrata Street, LV-1038 Riga, Latvia. AD - Doctoral Department, Faculty of Medicine, Riga Stradins University, 16 Dzirciema Street, LV-1007 Riga, Latvia. AD - Department of Rehabilitation, Riga Stradins University, 26a Anninmuizas Boulevard, LV-1067 Riga, Latvia. FAU - Lece, Anna AU - Lece A AUID- ORCID: 0000-0002-0970-2127 AD - Institute of Occupational Safety and Environmental Health, Riga Stradins University, LV-1067 Riga, Latvia. FAU - Skesters, Andrejs AU - Skesters A AUID- ORCID: 0000-0003-3726-8724 AD - Institute of Occupational Safety and Environmental Health, Riga Stradins University, LV-1067 Riga, Latvia. FAU - Cauce, Vinita AU - Cauce V AD - Statistics Unit, Riga Stradins University, 14 Balozu Street, LV-1048 Riga, Latvia. FAU - Zacs, Dzintars AU - Zacs D AD - Scientific Institute of Food Safety, Animal Health, and Environment, Lejupes Street 3, LV-1076 Riga, Latvia. FAU - Meija, Laila AU - Meija L AUID- ORCID: 0000-0002-8205-0639 AD - Riga East Clinical University Hospital, 2 Hipokrata Street, LV-1038 Riga, Latvia. AD - Department of Rehabilitation, Riga Stradins University, 26a Anninmuizas Boulevard, LV-1067 Riga, Latvia. LA - eng GR - Izp-2019/1-0335/Latvian Council of Science/ GR - 6-DN-20/4/2026/Riga Stradins University/ PT - Journal Article DEP - 20260901 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Fatty Acids) RN - 0 (Biomarkers) RN - 0 (Dietary Fats) SB - IM MH - Humans MH - Female MH - *Oxidative Stress MH - Pregnancy MH - *Fatty Acids/blood MH - Adult MH - *Life Style MH - *Erythrocyte Membrane/metabolism/chemistry MH - Cross-Sectional Studies MH - *Pregnancy Outcome MH - *Diet MH - Biomarkers/blood MH - Gestational Age MH - Infant, Newborn MH - Latvia MH - Nutritional Status MH - Dietary Fats PMC - PMC13567114 OTO - NOTNLM OT - fatty acids OT - nutrition OT - oxidative stress OT - pregnancy COIS- The authors declare no conflict of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 11:38 PMCR- 2026/09/01 CRDT- 2026/09/15 03:23 PHST- 2026/05/25 00:00 [received] PHST- 2026/08/04 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/15 11:38 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - nu18172859 [pii] AID - nutrients-18-02859 [pii] AID - 10.3390/nu18172859 [doi] PST - epublish SO - Nutrients. 2026 Sep 1;18(17):2859. doi: 10.3390/nu18172859. PMID- 42739020 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 31 TI - Trends and Contextual Factors Related to Obesity-Related Legislation in the Republic of Korea (2006-2024). LID - 10.3390/nu18172848 [doi] LID - 2848 AB - OBJECTIVES: The objective of this paper is to analyse trends in obesity-related legislation in the Republic of Korea (2006-2024) and examine political, institutional, and ideational factors observed in relation to legislative outcomes. METHODS: A retrospective policy analysis of 53 obesity-related bills identified through systematic searches of the National Assembly Legislative Information System and independently coded by two researchers. Quantitative trends were examined by policy domain and instrument type, and qualitative analysis applied Kingdon's Multiple Streams Framework, the Ideas-Interests-Institutions (3I) model, and Policy Instrument Theory. RESULTS: Legislative attention increased unevenly across the study period. Sixteen bills (30.2%) achieved a favorable legislative outcome, comprising direct passage or incorporation into an enacted committee alternative. Regulatory instruments dominated, followed by educational and institutional tools; fiscal measures were rare. Legislative activity clustered in 2013 and 2017-2019, while later proposals increasingly addressed school, digital, and post-pandemic concerns. CONCLUSIONS: Korea's experience shows both progress and fragmentation in obesity governance. Child-focused framing and institutional feasibility were recurrent features among enacted measures, whereas fiscal and structural proposals were less frequently enacted. The findings highlight the importance of considering regulatory, educational, and fiscal approaches within a comprehensive intersectoral policy framework. FAU - Lee, Yuri AU - Lee Y AUID- ORCID: 0000-0002-2780-7678 AD - Department of Health and Medical Information, Myongji College, Seoul 03656, Republic of Korea. AD - Department of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London WC1H 9SH, UK. FAU - Shin, Hyun-Young AU - Shin HY AD - Department of Family Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea. LA - eng PT - Journal Article DEP - 20260831 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Republic of Korea/epidemiology MH - Humans MH - *Obesity/prevention & control/epidemiology MH - *Health Policy/legislation & jurisprudence/trends MH - Retrospective Studies MH - Policy Making PMC - PMC13567622 OTO - NOTNLM OT - Republic of Korea OT - child nutrition OT - multiple streams framework OT - obesity legislation OT - public health policy COIS- The authors declare no conflict of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/31 CRDT- 2026/09/15 03:23 PHST- 2026/07/14 00:00 [received] PHST- 2026/08/21 00:00 [revised] PHST- 2026/08/22 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - nu18172848 [pii] AID - nutrients-18-02848 [pii] AID - 10.3390/nu18172848 [doi] PST - epublish SO - Nutrients. 2026 Aug 31;18(17):2848. doi: 10.3390/nu18172848. PMID- 42738991 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 28 TI - Dairy Product Consumption Patterns and Associated Sociodemographic and Lifestyle Factors Among Adults from Selected Peruvian Cities. LID - 10.3390/nu18172819 [doi] LID - 2819 AB - Background: Dairy products provide protein, calcium, and other essential nutrients, but intake may vary across sociodemographic and lifestyle groups. Objective: To characterize dairy consumption patterns and identify factors associated with consuming >/=3 dairy servings/day among adults recruited from selected Peruvian cities. Methods: A cross-sectional study was conducted from April to June 2026. Of the 1619 eligible participants, 203 (12.5%) reported no dairy consumption and were analyzed separately for reasons for non-consumption; the final analytical sample included 1265 dairy consumers. Dairy intake was assessed using a culturally adapted questionnaire with content validity evaluated by expert judgment. Descriptive analyses, bivariate tests, and multivariable logistic regression were performed. Results: Mean age was 33.0 +/- 13.0 years, and 61.2% were women. The most commonly consumed products were cheese (90.9%), yogurt (85.4%), whole milk (71.2%), and quesillo or fresh cheese (60.8%). Overall, 16.3% consumed >/=3 dairy servings/day. Participants recruited from cities in the Highlands (aOR = 0.54; 95% CI: 0.37-0.79) and Amazon (aOR = 0.59; 95% CI: 0.40-0.87) had lower odds of reaching this threshold than those from the Coast. Middle socioeconomic status was associated with lower odds (aOR = 0.48; 95% CI: 0.34-0.67), whereas physical activity >/=3 times/week was associated with higher odds (aOR = 1.53; 95% CI: 1.09-2.14). Perceived lactose intolerance was the most frequently reported reason for non-consumption (46.8%). Conclusions: Consumption of >/=3 dairy servings/day was uncommon. Socioeconomic differences were the most consistent correlate, while geographic and physical activity associations warrant cautious interpretation. FAU - Paz-Olivas, Youmi AU - Paz-Olivas Y AD - Area de Investigacion, Instituto de Nutricion y Seguridad Alimentaria, Lima 15026, Peru. AD - Escuela de Nutricion y Dietetica, Universidad Femenina Sagrado Corazon (UNIFE), La Molina, Lima 15023, Peru. FAU - Duran-Aguero, Samuel AU - Duran-Aguero S AUID- ORCID: 0000-0002-0548-3676 AD - Facultad de Ciencias de la Rehabilitacion y Calidad de Vida, Universidad San Sebastian, Providencia 7500000, Chile. FAU - Saintila, Jacksaint AU - Saintila J AUID- ORCID: 0000-0002-7340-7974 AD - Research Group on Nutritional Psychology and Public Health, Universidad Peruana Union, Lima 15464, Peru. LA - eng PT - Journal Article DEP - 20260828 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adult MH - Peru MH - *Dairy Products/statistics & numerical data MH - Cross-Sectional Studies MH - Male MH - *Life Style MH - Middle Aged MH - *Sociodemographic Factors MH - Young Adult MH - Socioeconomic Factors MH - Cities MH - *Diet/statistics & numerical data MH - *Feeding Behavior MH - Adolescent PMC - PMC13567231 OTO - NOTNLM OT - Peru OT - adults OT - dairy products OT - dietary intake OT - food consumption OT - lactose intolerance OT - socioeconomic status COIS- Y.P.-O. is employed as Nutrition Manager at Grupo Gloria, a company operating in the dairy sector. Grupo Gloria had no role in the funding of the study; study design; data collection, analysis, or interpretation; preparation or writing of the manuscript; or the decision to submit the manuscript for publication. S.D.-A. and J.S. declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/28 CRDT- 2026/09/15 03:23 PHST- 2026/08/03 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/28 00:00 [pmc-release] AID - nu18172819 [pii] AID - nutrients-18-02819 [pii] AID - 10.3390/nu18172819 [doi] PST - epublish SO - Nutrients. 2026 Aug 28;18(17):2819. doi: 10.3390/nu18172819. PMID- 42738983 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 27 TI - Development and Feasibility Study of Sustainable ePlate: A Web-Based Serious Game for Multidimensional Sustainable Healthy Diet Interventions in Schools. LID - 10.3390/nu18172812 [doi] LID - 2812 AB - BACKGROUND: School-based sustainable and healthy diet (SHD) interventions often inadequately capture the multidimensional nature of sustainability, with socioeconomic and cultural dimensions frequently underrepresented. While digital interventions can facilitate the integration of multiple SHD components, maintaining user engagement remains a persistent challenge that can compromise intervention effectiveness. Digital serious games represent a promising intervention strategy that can address both limitations by delivering multidimensional SHD content through interactive and engaging learning, while enabling real-time behavioral monitoring. OBJECTIVES: To assess the feasibility, as well as the acceptability and user experience of "Sustainable ePlate", a web-based serious game for multidimensional SHD educational interventions in schools, during school-based sessions. METHODS: Sustainable ePlate integrates food-level sustainability indicators into a scaffolded nine-challenge serious game. Challenges are presented through the healthy eating plate structure, while addressing eight food-level sustainability indicators transformed into 1-5 ordinal game scores. A database of 138 food items was developed from publicly available LCA and TCA databases. The game design draws on established learning theories implemented through progressive challenge sequencing, tiered feedback, and social features. Feasibility was assessed in guided school sessions in Northern Greece using the eGameFlow questionnaire and system in-app metrics. RESULTS: The assessment sample comprised n = 59 students from two secondary schools, of whom n = 57 completed the eGameFlow questionnaire. Mean overall enjoyment was 82.54 +/- 16.33%. Mean session duration was 22.39 +/- 12.68 min. Across all sessions, 6003 food selections were recorded, with 5179 correct and 824 incorrect placements, corresponding to an 86.27% placement accuracy rate. In-app metrics indicated strong technical feasibility, with all sessions completing the full game sequence. Behavioral metrics demonstrated active interaction, characterized by placement interval duration, hesitation times, and high placement accuracy. CONCLUSIONS: Sustainable ePlate demonstrated feasibility and a positive user experience as a school-based serious game for multidimensional SHD education, and as a research platform for capturing in-app behavioral metrics. Further studies are required to assess its educational effectiveness in improving knowledge, attitudes, and practices related to sustainable healthy diets through pre-post design interventions. FAU - Patra, Elena AU - Patra E AUID- ORCID: 0000-0002-8615-1541 AD - Nutrition Information Systems Laboratory (NISLAB), Department of Nutritional Sciences and Dietetics, International Hellenic University, 57400 Thessaloniki, Greece. FAU - Hassapidou, Maria AU - Hassapidou M AD - Nutrition Information Systems Laboratory (NISLAB), Department of Nutritional Sciences and Dietetics, International Hellenic University, 57400 Thessaloniki, Greece. FAU - Androutsos, Odysseas AU - Androutsos O AUID- ORCID: 0000-0002-2849-1994 AD - Laboratory of Clinical Nutrition and Dietetics, Department of Nutrition and Dietetics, School of Physical Education, Sports Science and Dietetics, University of Thessaly, 42132 Trikala, Greece. FAU - Diou, Christos AU - Diou C AUID- ORCID: 0000-0002-2461-1928 AD - Department of Informatics and Telematics, School of Digital Technology, Harokopio University of Athens, 17778 Athens, Greece. FAU - Pagkalos, Ioannis AU - Pagkalos I AUID- ORCID: 0000-0002-1538-4663 AD - Nutrition Information Systems Laboratory (NISLAB), Department of Nutritional Sciences and Dietetics, International Hellenic University, 57400 Thessaloniki, Greece. LA - eng PT - Journal Article DEP - 20260827 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Feasibility Studies MH - *Diet, Healthy/methods MH - *Video Games MH - Schools MH - Female MH - *Health Promotion/methods MH - Male MH - *Internet MH - Child MH - *School Health Services MH - Adolescent MH - Greece MH - Digital Media PMC - PMC13567481 OTO - NOTNLM OT - behavioral monitoring OT - digital interventions OT - gamification OT - nutrition education OT - school intervention OT - serious game OT - sustainable healthy diet COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/27 CRDT- 2026/09/15 03:23 PHST- 2026/07/16 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - nu18172812 [pii] AID - nutrients-18-02812 [pii] AID - 10.3390/nu18172812 [doi] PST - epublish SO - Nutrients. 2026 Aug 27;18(17):2812. doi: 10.3390/nu18172812. PMID- 42738982 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260929 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 27 TI - Mediterranean Diet Adherence, Nutrition Knowledge and Lifestyle Factors in Physically Active Adults and Athletes: The NUTRI_ACTIVE Study. LID - 10.3390/nu18172810 [doi] LID - 2810 AB - Background/Objectives: Unhealthy diets and poor lifestyle choices can increase athlete's risk of low energy availability (LEA) and its negative consequences. Conversely, optimal nutrition, such as the Mediterranean Diet (MedDiet), promotes health, recovery, and performance. This study evaluates MedDiet adherence among athletes and physically active individuals, exploring its relationship with nutrition knowledge (NK), dietary intake, eating behaviors, and sleep quality. Methods: This single-center observational study evaluated Italian healthy active adults/athletes (18-65 years) categorized into four performance Tiers. Validated questionnaires analyzed MedDiet adherence (MEDI-LITE), NK (GeSNK), eating behaviour (EAT-26 and TOS), sleep quality (PSQI), and physical activity (IPAQ). Dietary intake was estimated via a 7-day food diary. Body composition (skinfolds/BIVA), and resting energy expenditure (indirect calorimetry) were assessed. Results: Analysis included 169 participants (32.3 +/- 11.9 years; 52.7% females; 56.8% Tier 1), practicing 2.0 +/- 0.9 sports with 7.1 +/- 3.7 h/week of training. Mean MEDI-LITE score was 10.6 +/- 2.2 (moderate adherence) across all Tiers and was significantly, positively associated with NK (p = 0.002). Mean EA was 31.3 +/- 8.6 kcal/kg FFM/day; sex-specific cut-offs revealed a substantial proportion of high-tier participants with low/suboptimal EA. Eating disorder risk and orthorexic tendencies were low, sleep quality was generally good; none significantly correlated with MEDI-LITE score. Conclusions: Higher NK was positively associated with MedDiet adherence. However, high-tier athletes showed low or suboptimal EA. Targeted nutrition education must integrate MedDiet principles with sport-specific fueling strategies, optimizing diet quality and energy adequacy. FAU - Fiorini, Simona AU - Fiorini S AUID- ORCID: 0009-0005-2790-0601 AD - Laboratory of Food Education and Sport Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Guglielmetti, Monica AU - Guglielmetti M AUID- ORCID: 0000-0001-6327-9959 AD - Laboratory of Food Education and Sport Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Lopes Neri, Lenycia de Cassya AU - Lopes Neri LC AUID- ORCID: 0000-0002-4162-3664 AD - Laboratory of Food Education and Sport Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Ferraro, Ottavia Eleonora AU - Ferraro OE AUID- ORCID: 0000-0002-4398-4885 AD - Unit of Biostatistics and Clinical Epidemiology, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Rondanelli, Mariangela AU - Rondanelli M AUID- ORCID: 0000-0001-8336-4851 AD - Human Nutrition and Eating Disorder Research Center, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Tagliabue, Anna AU - Tagliabue A AUID- ORCID: 0000-0002-7647-6975 AD - Human Nutrition and Eating Disorder Research Center, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Ferraris, Cinzia AU - Ferraris C AUID- ORCID: 0000-0002-4148-2136 AD - Laboratory of Food Education and Sport Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. LA - eng GR - Project code PE0000003/Ministry of Universities and Research/ PT - Journal Article PT - Observational Study DEP - 20260827 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Diet, Mediterranean MH - Female MH - Male MH - Adult MH - *Athletes/psychology/statistics & numerical data MH - Young Adult MH - Middle Aged MH - *Life Style MH - *Health Knowledge, Attitudes, Practice MH - Adolescent MH - Feeding Behavior MH - *Exercise MH - Aged MH - Italy MH - Surveys and Questionnaires MH - *Patient Compliance MH - Energy Metabolism MH - Energy Intake MH - Body Composition MH - Sleep Quality MH - Nutritional Status PMC - PMC13567227 OTO - NOTNLM OT - athletes OT - energy availability OT - lifestyle OT - mediterranean diet OT - nutrition knowledge OT - sport nutrition COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/27 CRDT- 2026/09/15 03:23 PHST- 2026/07/21 00:00 [received] PHST- 2026/08/22 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - nu18172810 [pii] AID - nutrients-18-02810 [pii] AID - 10.3390/nu18172810 [doi] PST - epublish SO - Nutrients. 2026 Aug 27;18(17):2810. doi: 10.3390/nu18172810. PMID- 42738966 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 26 TI - Associations and Multidimensional Characterization of the Nutritional-Inflammatory Profile in Children with Previous SARS-CoV-2 Infection: A Retrospective Cohort Study. LID - 10.3390/nu18172793 [doi] LID - 2793 AB - Background/Objectives: Nutritional, inflammatory, and lifestyle-related characteristics may contribute to substantial biological heterogeneity among children with documented previous SARS-CoV-2 infection. This study aimed to characterize an integrated nutritional-inflammatory profile and explore its relationships with biological and clinical features in a hospitalized pediatric cohort. Methods: This retrospective cohort study included 260 children with documented previous SARS-CoV-2 infection. Clinical, anthropometric, and laboratory data were complemented by questionnaire-derived dietary and lifestyle information (n = 213). Analyses combined conventional statistics with correlation and multivariate techniques, including PCA and K-means clustering (n = 231) and exploratory Ridge regression (n = 188). Results: Suboptimal serum 25(OH)D concentrations (<30 ng/mL) were present in 55.8% of participants (95% CI [49.7%, 61.7%]), while 43.5% were overweight or obese (95% CI [37.6%, 49.5%]). BMI correlated with hemoglobin (rho = 0.23) and CRP (rho = 0.12), while 25(OH)D correlated with potassium (rho = 0.22). Increasing daily device use was associated with progressively lower 25(OH)D concentrations (H = 24, p < 0.001, epsilon(2) = 0.11), with median values decreasing from 33 ng/mL at <1 h/day to 24 ng/mL at >4 h/day. PCA identified three complementary biological dimensions explaining 55.0% of the total variance, while K-means clustering identified three reproducible exploratory nutritional-inflammatory phenotypes differentiated by age, BMI, hematological and inflammatory characteristics, and selected lifestyle factors. Conclusions: The findings show multidimensional nutritional-inflammatory heterogeneity in children with documented previous SARS-CoV-2 infection. The identified patterns and exploratory phenotypes provide an integrated framework for biological characterization and warrant validation in prospective multicenter cohorts. FAU - Petrea Cliveti, Carmen Loredana AU - Petrea Cliveti CL AUID- ORCID: 0009-0001-8838-8817 AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania. FAU - Ciortea, Diana-Andreea AU - Ciortea DA AUID- ORCID: 0000-0001-7420-256X AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Maria Sklodowska Curie" Emergency Clinical Hospital for Children, 041451 Bucharest, Romania. FAU - Gurau, Gabriela AU - Gurau G AUID- ORCID: 0000-0001-8327-1364 AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania. FAU - Matei, Madalina Nicoleta AU - Matei MN AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania. FAU - Barbu, Codrina AU - Barbu C AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania. FAU - Verga Rauta, Gabriela Isabela AU - Verga Rauta GI AUID- ORCID: 0009-0009-5438-666X AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania. FAU - Lungu, Irinel AU - Lungu I AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. AD - "Sf. Ioan" Emergency Clinical Hospital for Children, 800487 Galati, Romania. FAU - Valcan, Mariana Mirela AU - Valcan MM AUID- ORCID: 0000-0001-5347-4267 AD - Faculty of Medicine and Pharmacy, University of Oradea, 410087 Oradea, Romania. FAU - Berbece, Sorin Ion AU - Berbece SI AD - Research Center in the Medico-Pharmaceutical Field, Faculty of Medicine and Pharmacy, "Dunarea de Jos" University of Galati, 800008 Galati, Romania. LA - eng PT - Journal Article DEP - 20260826 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Humans MH - *COVID-19 MH - Retrospective Studies MH - Female MH - SARS-CoV-2 MH - Child MH - Male MH - *Nutritional Status MH - Vitamin D/blood/analogs & derivatives MH - *Inflammation/blood MH - Adolescent MH - Life Style MH - Body Mass Index MH - Child, Preschool PMC - PMC13567281 OTO - NOTNLM OT - 25-hydroxyvitamin D OT - children OT - exploratory phenotypes OT - inflammatory biomarkers OT - lifestyle OT - nutritional-inflammatory profile OT - previous SARS-CoV-2 infection OT - principal component analysis COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 11:37 PMCR- 2026/08/26 CRDT- 2026/09/15 03:23 PHST- 2026/07/13 00:00 [received] PHST- 2026/08/20 00:00 [revised] PHST- 2026/08/22 00:00 [accepted] PHST- 2026/09/15 11:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/26 00:00 [pmc-release] AID - nu18172793 [pii] AID - nutrients-18-02793 [pii] AID - 10.3390/nu18172793 [doi] PST - epublish SO - Nutrients. 2026 Aug 26;18(17):2793. doi: 10.3390/nu18172793. PMID- 42738956 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 26 TI - Beverage Consumption Patterns, Beverage-Derived Energy Intake, and Adherence to Fluid Intake Recommendations Among Polish Adolescents: A Cross-Sectional Study Using the BEVQ-PL Questionnaire. LID - 10.3390/nu18172784 [doi] LID - 2784 AB - Background/Objectives: Different organizations have established fluid intake recommendations for adolescents; however, studies assessing adherence typically rely on a single reference system, limiting comparisons across populations. This study assessed beverage consumption patterns and beverage-derived energy intake among Polish adolescents and examined how adherence estimates differed when recommendations issued by the European Food Safety Authority (EFSA), the Institute of Medicine (IOM), and the Polish National Institute of Public Health-National Institute of Hygiene (NIH) were applied. Methods: A cross-sectional study was conducted among 1644 secondary school students aged 14-18 years. Beverage consumption (mL/day) and beverage-derived energy intake (kcal/day) were assessed using the validated Polish Beverage Intake Questionnaire (BEVQ-PL). Adherence was defined as achieving at least 80% of the age- and sex-specific Adequate Intake (AI) from beverages, assuming that beverages provide approximately 80% of total daily water intake. Results: Water had the highest median daily intake (960 mL/day). Males consumed significantly more water than females (1080 vs. 720 mL/day; p = 0.037), whereas females consumed significantly more reduced-fat milk (2%), skim milk, plant-based and flavored milk beverages, 100% vegetable juice, and coffee with milk and sugar. Adherence differed according to the recommendation system, reaching 65.2% (EFSA), 50.6% (IOM), and 65.8% (NIH). Female sex was independently associated with higher adherence across all three reference systems, whereas older age was associated with lower adherence only according to the NIH criteria and overweight/obesity only according to the IOM criteria. Conclusions: Estimated adherence to fluid intake recommendations varied substantially according to the reference system applied. These findings highlight the importance of explicitly reporting the selected reference criteria when assessing and comparing the adequacy of beverage-derived fluid intake among adolescents. FAU - Zborowski, Marek AU - Zborowski M AUID- ORCID: 0000-0003-2695-2491 AD - The Faculty of Medicine and Health Sciences, University of Applied Sciences in Nowy Sacz, Kosciuszki 2G, 33-300 Nowy Sacz, Poland. FAU - Skotnicka, Magdalena AU - Skotnicka M AUID- ORCID: 0000-0002-0853-0685 AD - Department of Commodity Science, Faculty of Health Sciences, Medical University of Gdansk, 7 Debinki Street, 80-210 Gdansk, Poland. LA - eng PT - Journal Article DEP - 20260826 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Cross-Sectional Studies MH - Female MH - Male MH - *Beverages MH - Poland MH - *Energy Intake MH - *Drinking MH - Surveys and Questionnaires MH - Recommended Dietary Allowances MH - Animals MH - Guideline Adherence MH - *Patient Compliance PMC - PMC13567327 OTO - NOTNLM OT - BEVQ-PL OT - adequate intake OT - adolescents OT - beverage consumption OT - hydration recommendations COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/26 CRDT- 2026/09/15 03:23 PHST- 2026/08/01 00:00 [received] PHST- 2026/08/22 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/26 00:00 [pmc-release] AID - nu18172784 [pii] AID - nutrients-18-02784 [pii] AID - 10.3390/nu18172784 [doi] PST - epublish SO - Nutrients. 2026 Aug 26;18(17):2784. doi: 10.3390/nu18172784. PMID- 42738947 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260922 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 25 TI - Association of Sleep Duration and Physical Activity with Healthy Eating Habits Among Peruvian Secondary School Students. LID - 10.3390/nu18172775 [doi] LID - 2775 AB - Background/Objectives: Sleep duration and physical activity are key behavioral components in the development of healthy lifestyles during adolescence. In Peru, a considerable proportion of school students do not meet recommended levels of physical activity and may also experience insufficient sleep, which could negatively affect their eating habits. This study aimed to analyze the association between sleep duration, physical activity level, and healthy eating habits among Peruvian secondary school students. Methods: An observational, analytical, cross-sectional study was conducted among 275 secondary school students aged 12 to 17 years. Sleep duration, physical activity, and eating habits were assessed using validated questionnaires. Associations were analyzed using Pearson's chi-square test and multivariable binary logistic regression. Results: Students who slept 7 h had higher odds of having healthy eating habits compared with those who slept 6 h or less (aOR = 2.525; 95% CI: 1.181-5.536; p = 0.018). In addition, students with low levels of physical activity showed lower odds of having healthy eating habits compared with those with high levels of physical activity (aOR = 0.097; 95% CI: 0.005-0.564; p = 0.032). Conclusions: Sleep duration and physical activity were associated with healthy eating habits among Peruvian secondary school students. These findings support the importance of promoting integrated school-based strategies that jointly address sleep, physical activity, and nutrition during adolescence. FAU - Remon-Lopez, Jennyfer A AU - Remon-Lopez JA AD - Escuela de Nutricion Humana, Facultad de Ciencias de la Salud, Universidad Peruana Union, Lima 15102, Peru. FAU - Chilon-Llico, Raquel AU - Chilon-Llico R AD - Escuela de Nutricion Humana, Facultad de Ciencias de la Salud, Universidad Peruana Union, Lima 15102, Peru. FAU - Peralta-Eugenio, Gutember AU - Peralta-Eugenio G AUID- ORCID: 0000-0002-1177-6088 AD - Facultad de Ciencias de la Salud, Escuela de Psicologia, Universidad Cesar Vallejo, Chimbote 02801, Peru. FAU - Morales-Garcia, Wilter C AU - Morales-Garcia WC AUID- ORCID: 0000-0003-1208-9121 AD - Facultad de Teologia, Universidad Peruana Union, Lima 15102, Peru. FAU - Sairitupa-Sanchez, Liset Z AU - Sairitupa-Sanchez LZ AUID- ORCID: 0000-0003-0555-091X AD - Escuela de Psicologia, Universidad Senor de Sipan, Chiclayo 14001, Peru. FAU - Morales-Garcia, Sandra B AU - Morales-Garcia SB AUID- ORCID: 0000-0002-5102-303X AD - Escuela de Medicina Humana, Universidad Senor de Sipan, Chiclayo 14001, Peru. FAU - Rivera-Lozada, Oriana AU - Rivera-Lozada O AD - Escuela de Medicina Humana, Universidad Senor de Sipan, Chiclayo 14001, Peru. FAU - Morales-Garcia, Mardel AU - Morales-Garcia M AUID- ORCID: 0000-0002-6413-1072 AD - Direccion de Investigacion, Escuela de Posgrado, Universidad Peruana Union, Lima 15102, Peru. LA - eng PT - Journal Article PT - Observational Study DEP - 20260825 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - *Sleep Duration MH - Peru MH - Female MH - Male MH - Cross-Sectional Studies MH - Child MH - *Exercise MH - *Feeding Behavior MH - *Students/statistics & numerical data MH - *Diet, Healthy MH - Schools MH - Surveys and Questionnaires MH - Logistic Models MH - *Sleep MH - Adolescent Behavior PMC - PMC13567383 OTO - NOTNLM OT - Peru OT - adolescents OT - healthy eating habits OT - physical activity OT - sleep duration COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/25 CRDT- 2026/09/15 03:23 PHST- 2026/04/14 00:00 [received] PHST- 2026/05/01 00:00 [revised] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - nu18172775 [pii] AID - nutrients-18-02775 [pii] AID - 10.3390/nu18172775 [doi] PST - epublish SO - Nutrients. 2026 Aug 25;18(17):2775. doi: 10.3390/nu18172775. PMID- 42738945 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 25 TI - The Gut-Brain Axis and Dietary Patterns in Shaping Long-Term Neurocognitive and Psychosocial Outcomes in Adolescent and Young Adult Survivors of Childhood Cancer: A Systematized Narrative Review. LID - 10.3390/nu18172773 [doi] LID - 2773 AB - Background: The dynamic advancement of pediatric hemato-oncology and intensified therapeutic protocols have significantly increased survival rates while simultaneously highlighting the challenge of long-term treatment complications. Within the cohort of adolescent and young adult (AYA) survivors, delayed neurocognitive deficits, often manifesting as the chemobrain phenotype, and psychosocial disorders constitute a particularly substantial burden. Contemporary neurogastroenterological evidence indicates a fundamental role of persistent dysbiosis and gut-brain axis dysfunction in the pathogenesis of these alterations. This review aims to critically synthesize translational evidence elucidating the impact of iatrogenic gut microbiota damage and modifiable dietary patterns on the development of long-term neurocognitive sequelae in survivors of early childhood cancer. Methods: A systematized narrative review was conducted in accordance with the SANRA guidelines by integrating data from in vivo models and observational studies. A comprehensive literature search across the PubMed, Embase, Cochrane Central, Scopus, and Web of Science databases up to June 2026 was performed utilizing the Population, Exposure, and Outcomes (PEO) framework. Results: Oncological therapies, including myeloablative conditioning and broad-spectrum antibiotic therapy, induce a microbial scar phenomenon characterized by the depletion of commensal Firmicutes in favor of resistant pathobionts. The subsequent decline in the synthesis of neuroprotective short-chain fatty acids (SCFAs) alongside the pathological activation of the kynurenine pathway disrupts central nervous system homeostasis. Translocation of lipopolysaccharides (LPSs) across the compromised intestinal barrier generates systemic inflammation recognized as inflammaging, which, in turn, stimulates neurotoxic microglial hyperreactivity. This pathophysiological cascade is accelerated by a pro-inflammatory Western diet, whereas anti-inflammatory interventions such as the MIND diet and postbiotics demonstrate measurable restorative potential. Conclusions: The pathophysiology of delayed neurotoxicity is largely a consequence of systemic neuroinflammation driven by intestinal dysbiosis. Implementing individualized dietary and microbiome-targeted strategies into survivorship care protocols constitutes a crucial direction for clinical prophylaxis. Validating their clinical efficacy in the AYA population necessitates prospective randomized controlled trials integrated with shotgun metagenomic sequencing. FAU - Pawlowski, Piotr AU - Pawlowski P AUID- ORCID: 0000-0002-1197-7218 AD - Department of Psychology, Psychosocial Aspects of Medicine, Faculty of Medicine, Medical University of Lublin, 20-093 Lublin, Poland. AD - Institute of Medical Sciences, University of Applied Sciences in Chelm, 22-100 Chelm, Poland. FAU - Kosciolek, Otylia AU - Kosciolek O AD - Student Scientific Club at the Department of Psychology, Faculty of Medicine, Medical University of Lublin, 20-093 Lublin, Poland. FAU - Jezak, Mikolaj AU - Jezak M AUID- ORCID: 0009-0009-2014-3985 AD - I Department of Anaesthesiology and Intensive Care, University Clinical Hospital No. 4 in Lublin, 20-090 Lublin, Poland. FAU - Jakubik, Karol AU - Jakubik K AUID- ORCID: 0009-0005-8880-3522 AD - Doctoral School, Medical University of Lublin, 20-093 Lublin, Poland. AD - I Department of Medical Radiology, Medical University of Lublin, 20-090 Lublin, Poland. FAU - Kosciolek, Aneta AU - Kosciolek A AUID- ORCID: 0000-0001-5712-1629 AD - Institute of Medical Sciences, University of Applied Sciences in Chelm, 22-100 Chelm, Poland. FAU - Samardakiewicz, Marzena AU - Samardakiewicz M AUID- ORCID: 0000-0002-2793-0756 AD - Department of Psychology, Psychosocial Aspects of Medicine, Faculty of Medicine, Medical University of Lublin, 20-093 Lublin, Poland. LA - eng PT - Journal Article PT - Review DEP - 20260825 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - *Cancer Survivors/psychology MH - *Gastrointestinal Microbiome/physiology MH - Young Adult MH - *Diet MH - *Brain-Gut Axis/physiology MH - *Neoplasms/psychology MH - Dysbiosis MH - Child MH - *Brain PMC - PMC13567169 OTO - NOTNLM OT - adolescent and young adult (AYA) OT - childhood cancer survivors OT - dietary patterns OT - human gut microbiota OT - long-term follow-up (LTFU) OT - neurocognitive functioning OT - psychosocial functioning COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/25 CRDT- 2026/09/15 03:23 PHST- 2026/07/26 00:00 [received] PHST- 2026/08/20 00:00 [revised] PHST- 2026/08/23 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - nu18172773 [pii] AID - nutrients-18-02773 [pii] AID - 10.3390/nu18172773 [doi] PST - epublish SO - Nutrients. 2026 Aug 25;18(17):2773. doi: 10.3390/nu18172773. PMID- 42738936 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 24 TI - Prehabilitation Practices for Paediatric Haematopoietic Stem Cell Transplantation: A Survey and Patient and Public Involvement Study of Healthcare Professionals. LID - 10.3390/nu18172762 [doi] LID - 2762 AB - Background/Objectives: Haematopoietic stem cell transplantation (HSCT) causes substantial morbidity in children and young people (CYP). Although prehabilitation benefits adults with cancer, its role in paediatric HSCT remains underexplored. This study aimed to describe current pre-transplant assessment and supportive care practices across paediatric HSCT centres, explore healthcare professional perspectives on prehabilitation implementation, and integrate patient and public involvement (PPI) to inform future intervention design. Methods: A cross-sectional survey was administered to healthcare professionals across 16 paediatric HSCT centres in the UK and the Republic of Ireland, alongside semi-structured PPI discussions conducted with eight children, young people, and caregivers with direct experience of paediatric HSCT. Survey data were analysed descriptively, free-text responses by qualitative content analysis, and PPI by reflexive thematic analysis. Results: Forty-nine eligible responses were received from healthcare professionals. Formal prehabilitation services were reported by 27 (55.1%) respondents, with substantial within-centre variation. Nutritional advice was the most consistently delivered component, 36 (72%), whilst physical activity interventions were the least consistently provided, 13 (26%). Workforce limitations were identified as the dominant barrier by 37 (95%) respondents. PPI findings described provision as reactive and inconsistent, with families expressing preference for flexible, hybrid, and family-centred delivery models. Conclusions: Prehabilitation provision in paediatric HSCT is variable, often informal, and limited by workforce capacity. CYP and caregivers expressed a desire for prehabilitation, particularly through flexible, hybrid (face-to-face and online), and family-centred approaches. Future research should prioritise co-design and feasibility testing of safe, individually tailored programmes that can be integrated into paediatric HSCT pathways. FAU - AbuSalameh, Hala AU - AbuSalameh H AD - Public Health and Sports Sciences, Faculty of Life and Health Sciences, Medical School, University of Exeter, Exeter EX1 2LU, UK. FAU - Revuelta Iniesta, Raquel AU - Revuelta Iniesta R AUID- ORCID: 0000-0002-5534-7146 AD - Public Health and Sports Sciences, Faculty of Life and Health Sciences, Medical School, University of Exeter, Exeter EX1 2LU, UK. FAU - Rowley, Deborah AU - Rowley D AD - Public Health and Sports Sciences, Faculty of Life and Health Sciences, Medical School, University of Exeter, Exeter EX1 2LU, UK. AD - Haematology and Oncology, Sheffield Children's NHS Foundation Trust, Clarkson Street, Broomhall, Sheffield S10 2TH, UK. LA - eng GR - N/A/Children's Cancer and Leukaemia Group/ PT - Journal Article DEP - 20260824 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Hematopoietic Stem Cell Transplantation MH - Cross-Sectional Studies MH - Child MH - Female MH - Adolescent MH - Male MH - Surveys and Questionnaires MH - *Patient Participation MH - United Kingdom MH - *Health Personnel MH - Ireland MH - *Preoperative Care/methods MH - Adult MH - Child, Preschool PMC - PMC13567236 OTO - NOTNLM OT - children and young people OT - haematopoietic stem cell transplantation OT - healthcare professionals OT - patient and public involvement OT - prehabilitation COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/24 CRDT- 2026/09/15 03:23 PHST- 2026/07/16 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/24 00:00 [pmc-release] AID - nu18172762 [pii] AID - nutrients-18-02762 [pii] AID - 10.3390/nu18172762 [doi] PST - epublish SO - Nutrients. 2026 Aug 24;18(17):2762. doi: 10.3390/nu18172762. PMID- 42738928 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 23 TI - Adverse Events Following Cow's Milk-Derived Human Milk Fortification: A Nationwide Human Milk Bank Study. LID - 10.3390/nu18172755 [doi] LID - 2755 AB - Background: Cow's milk-derived fortifier (CMDF) is widely used to improve the nutritional adequacy of human milk for very preterm infants. Although generally well-tolerated, feeding difficulties may occur during CMDF use. Characterizing these events and their associated clinical factors may improve the understanding of feeding tolerance in routine neonatal practice. Objective: To characterize documented adverse feeding events among infants receiving donor human milk (DHM) and CMDF and to identify clinical characteristics associated with these events. Methods: This retrospective nationwide cohort study used the Japanese Human Milk Bank Database. Infants receiving DHM and CMDF were included. Clinical characteristics were compared between infants with and without documented adverse feeding events, and multivariable logistic regression was used to evaluate associated factors. Results: Among the 2587 infants receiving DHM and CMDF, 2476 had available adverse-event information. Adverse feeding events were documented in 315 infants (12.7%), most commonly abdominal distension, increased gastric residuals, vomiting, and suspected cow's milk protein allergy. Infants with documented adverse feeding events had lower gestational age and birth weight and required longer to reach an enteral feeding volume of 100 mL/kg/day. In multivariable analysis, delayed achievement of 100 mL/kg/day remained associated with documented adverse feeding events, whereas gestational age, birth weight, and sex were not independently associated. Routine clinical variables showed limited discriminatory ability (AUC 0.611). Conclusions: Most infants receiving CMDF had no documented adverse feeding events. Slower progression to an enteral feeding volume of 100 mL/kg/day was associated with documented adverse feeding events; however, the temporal relationship among feeding progression, CMDF initiation, and adverse events could not be established. These findings should therefore be considered hypothesis-generating rather than predictive and require prospective validation. FAU - Tani, Yuki AU - Tani Y AUID- ORCID: 0009-0008-0402-1331 AD - Department of Pediatrics, Showa Medical University, Tokyo 142-8666, Japan. AD - Department of Pediatrics, Nara Medical University, Kashihara 634-8522, Japan. FAU - Mizuno, Katsumi AU - Mizuno K AUID- ORCID: 0000-0002-6983-8851 AD - Department of Pediatrics, Showa Medical University, Tokyo 142-8666, Japan. LA - eng GR - 25DA0601/Japan Child and Family Research Institute/ PT - Journal Article DEP - 20260823 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Milk, Human MH - Female MH - Retrospective Studies MH - *Milk Banks MH - Infant, Newborn MH - Animals MH - Male MH - *Food, Fortified/adverse effects MH - Japan MH - Enteral Nutrition MH - Infant, Premature MH - *Milk MH - Cattle MH - Infant MH - Milk Hypersensitivity/etiology PMC - PMC13567376 OTO - NOTNLM OT - cow's milk-derived fortifier OT - donor human milk OT - human milk fortification COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/23 CRDT- 2026/09/15 03:23 PHST- 2026/07/04 00:00 [received] PHST- 2026/08/12 00:00 [revised] PHST- 2026/08/20 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/23 00:00 [pmc-release] AID - nu18172755 [pii] AID - nutrients-18-02755 [pii] AID - 10.3390/nu18172755 [doi] PST - epublish SO - Nutrients. 2026 Aug 23;18(17):2755. doi: 10.3390/nu18172755. PMID- 42738923 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 17 DP - 2026 Aug 22 TI - Prenatal, Perinatal and Postnatal Exposures and Clinical Factors of Food Allergy Prevention: A Review for the First 1000 Days of Life from the SIAIP Primary and Secondary Prevention of Allergic Diseases Commission. LID - 10.3390/nu18172749 [doi] LID - 2749 AB - Food allergy prevention is no longer understood as the simple avoidance of allergenic foods. The first 1000 days (from conception to, approximately, 24 months of age) include prenatal, perinatal and postnatal windows in which diet, epithelial barrier integrity, microbial ecology, immune maturation and family-level implementation interact. This narrative review was developed as a Commission-proposed SIAIP-oriented clinical framework, rather than a formal guideline or consensus statement. Evidence from guidelines, systematic reviews, randomised trials, birth cohorts and mechanistic studies was organised by developmental window and interpreted according to endpoint validity, confounding, feasibility and clinical readiness. Prenatal factors include maternal allergen non-avoidance, whole-diet quality, micronutrient and fatty acid status, antibiotic exposure, environmental context and maternal microbiome. Perinatal factors include mode of delivery, intrapartum and neonatal antibiotics, gestational maturity, early colonisation, breastfeeding initiation and routine vaccination. Postnatal factors include eczema, skin barrier inflammation, the timing and regularity of allergen introduction, breastfeeding management, infant diet diversity, siblings, daycare, pets, smoke and pollution, physical activity and equitable implementation. The strongest actionable evidence remains eczema-linked risk recognition and timely, sustained oral exposure to peanut and well-cooked egg. Maternal and environmental factors are clinically important, but many are contextual rather than prescriptive; they should guide non-restrictive, non-blaming counselling rather than deterministic risk labelling. FAU - Klain, Angela AU - Klain A AUID- ORCID: 0000-0001-7823-2125 AD - Department of Woman, Child and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy. FAU - Cascone, Salvatore AU - Cascone S AUID- ORCID: 0009-0009-6327-1119 AD - Department of Woman, Child and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy. FAU - Grella, Carolina AU - Grella C AUID- ORCID: 0009-0006-5029-7895 AD - Department of Woman, Child and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy. FAU - Cattivera, Valentina AU - Cattivera V AUID- ORCID: 0009-0008-6786-1506 AD - Department of Pediatrics, University of L'Aquila, 67100 L'Aquila, Italy. FAU - Fabiano, Cecilia AU - Fabiano C AD - Department of Pediatrics, University of L'Aquila, 67100 L'Aquila, Italy. FAU - Galletta, Francesca AU - Galletta F AUID- ORCID: 0000-0002-4166-2030 AD - Pediatric Unit, Department of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', University of Messina, 98124 Messina, Italy. FAU - Manti, Sara AU - Manti S AUID- ORCID: 0000-0001-5420-8411 AD - Pediatric Unit, Department of Human Pathology in Adult and Developmental Age 'Gaetano Barresi', University of Messina, 98124 Messina, Italy. FAU - Senatore, Antonio Andrea AU - Senatore AA AUID- ORCID: 0000-0003-3377-9252 AD - Pediatric Clinic, Fondazione IRCCS Policlinico, 27100 Pavia, Italy. FAU - Licari, Amelia AU - Licari A AUID- ORCID: 0000-0002-1773-6482 AD - Pediatric Clinic, Fondazione IRCCS Policlinico, 27100 Pavia, Italy. AD - Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy. FAU - Miraglia Del Giudice, Michele AU - Miraglia Del Giudice M AUID- ORCID: 0000-0002-8369-5957 AD - Department of Woman, Child and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy. FAU - Marseglia, Gian Luigi AU - Marseglia GL AD - Pediatric Unit, Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy. FAU - Indolfi, Cristiana AU - Indolfi C AUID- ORCID: 0000-0002-9513-193X AD - Department of Woman, Child and General and Specialized Surgery, University of Campania 'Luigi Vanvitelli', 80138 Naples, Italy. CN - SIAIP Primary and Secondary Prevention of Allergic Diseases Commission LA - eng PT - Journal Article PT - Review DEP - 20260822 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Food Hypersensitivity/prevention & control MH - Female MH - Pregnancy MH - Infant MH - Infant, Newborn MH - Breast Feeding MH - *Prenatal Exposure Delayed Effects MH - Risk Factors MH - Diet MH - Developmental Origins of Health and Disease PMC - PMC13567279 OTO - NOTNLM OT - breastfeeding OT - children OT - eczema OT - environment OT - food allergy OT - microbiome OT - oral tolerance OT - perinatal factors OT - pregnancy OT - prevention OT - siblings OT - vaccination COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/22 CRDT- 2026/09/15 03:23 PHST- 2026/07/16 00:00 [received] PHST- 2026/08/18 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:23 [entrez] PHST- 2026/08/22 00:00 [pmc-release] AID - nu18172749 [pii] AID - nutrients-18-02749 [pii] AID - 10.3390/nu18172749 [doi] PST - epublish SO - Nutrients. 2026 Aug 22;18(17):2749. doi: 10.3390/nu18172749. PMID- 42738299 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260915 LR - 20260917 IS - 2072-6694 (Print) IS - 2072-6694 (Electronic) IS - 2072-6694 (Linking) VI - 18 IP - 17 DP - 2026 Aug 27 TI - Multi-Target HCC Blood Test Demonstrates Consistent Performance Across Subgroups of Patients with Chronic Liver Disease. LID - 10.3390/cancers18172777 [doi] LID - 2777 AB - BACKGROUND: Early detection of hepatocellular carcinoma (HCC) is critical for improving patient outcomes; however, ultrasound-based surveillance has limited sensitivity and variable performance across patient populations. We evaluated the performance of a multitarget HCC blood test (mt-HBT), incorporating methylated DNA markers, alpha-fetoprotein (AFP), and patient sex, across clinically relevant subgroups. METHODS: We performed a subgroup analysis of a multicenter, prospective case-control study that included 159 patients with early-stage HCC (Barcelona Clinic Liver Cancer Stage 0/A) and 649 control patients with cirrhosis or chronic hepatitis B without HCC. The mt-HBT combined methylated HOXA1, TSPYL5, and B3GALT6 markers with AFP and sex. Sensitivity and specificity were evaluated overall and according to age, sex, obesity, liver disease etiology, Child Pugh class, and tumor size. Performance was compared with AFP and GALAD. RESULTS: Overall sensitivity and specificity of mt-HBT for early-stage HCC detection were 76.7% (95% CI, 69.6-82.6) and 87.5% (95% CI, 84.8-89.8), respectively. Sensitivity was significantly higher than that of AFP (35.2%, p < 0.001) and comparable to that of GALAD (78.6%, p = 0.56), whereas specificity was lower than that of AFP (98.5%, p < 0.001) but higher than that of GALAD (76.9%, p < 0.001). Sensitivity was maintained across key subgroups, including patients with obesity (68.9%), Child Pugh B cirrhosis (75.0%), hepatitis C (80.0%), hepatitis B (72.2%), alcohol-associated liver disease (80.5%), and metabolic dysfunction-associated steatotic disease (69.0%) (all p > 0.05 between subgroups). Specificity exceeded 80% in all examined populations and was significantly higher in women than in men (92.5% vs. 83.9%, p < 0.001). Sensitivity increased with tumor size, ranging from 60.0% for tumors < 2 cm to 100% for tumors > 5 cm. CONCLUSIONS: The mt-HBT demonstrated robust, consistent performance for early-stage HCC detection across diverse patient populations, including subgroups in which ultrasound surveillance commonly underperforms. These findings support the prospective validation of mt-HBT as a blood-based surveillance strategy for HCC. FAU - Singal, Amit G AU - Singal AG AD - Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX 75390, USA. FAU - Camardo, Mark AU - Camardo M AD - Abbott, Madison, WI 53719, USA. FAU - Bruinsma, Janelle J AU - Bruinsma JJ AD - Abbott, Madison, WI 53719, USA. FAU - Kielar-Grevstad, Elle AU - Kielar-Grevstad E AD - Abbott, Madison, WI 53719, USA. FAU - Chalasani, Naga AU - Chalasani N AUID- ORCID: 0000-0003-4082-3178 AD - Department of Internal Medicine, Indiana University, Indianapolis, IN 46202, USA. FAU - John, Binu V AU - John BV AUID- ORCID: 0000-0002-2002-9682 AD - Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA. AD - Division of Gastroenterology and Hepatology, Miami VA Health System, Miami, FL 33136, USA. LA - eng GR - U01 CA283935/CA/NCI NIH HHS/United States GR - U01 CA283935; U01 CA271887; P50 CA295495; CPRIT RP200554/CA/NCI NIH HHS/United States GR - I01 CX002654/CX/CSRD VA/United States GR - U01 CA271887/CA/NCI NIH HHS/United States GR - VA MERIT I01CX002654 01A1/VA clinical science research and development/ GR - P50 CA295495/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20260827 PL - Switzerland TA - Cancers (Basel) JT - Cancers JID - 101526829 PMC - PMC13565293 OTO - NOTNLM OT - liver cancer OT - mt-HBT OT - screening OT - surveillance OT - ultrasound COIS- Dr. Singal has served as a consultant or on advisory boards for Genentech, AstraZeneca, Eisai, Exelixis, Bayer, Merck, Elevar, Boston Scientific, Sirtex, FujiFilm Medical Sciences, Exact Sciences, Helio Genomics, Roche, Glycotest, ImCare, Curve Bio, DELFI, Mursla, Universal Dx, and Abbott. Dr. Chalasani serves as a consultant to Madrigal, GSK, Altimmune, Insitro, Eccogene, Akero, Boston Pharmaceuticals, Zydus, He receives research support from Boerhinger-Ingelheim and Exact Sciences. He has equity in Heligenics, a drug discovery start-up company and Avant Sante, a contract research organization. Dr. John received institutional research support from Exact Sciences, Genentech, and Takeda. Dr. Bruinsma, Dr. Kielar-Grevstad, and Mr. Camardo are employees of Exact Sciences (now Abbott) and were involved in the study design, data interpretation, manuscript preparation, and review. All authors have reviewed and approved the final manuscript. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/27 CRDT- 2026/09/15 03:22 PHST- 2026/07/30 00:00 [received] PHST- 2026/08/24 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:22 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - cancers18172777 [pii] AID - cancers-18-02777 [pii] AID - 10.3390/cancers18172777 [doi] PST - epublish SO - Cancers (Basel). 2026 Aug 27;18(17):2777. doi: 10.3390/cancers18172777. PMID- 42737710 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 27 IP - 17 DP - 2026 Aug 31 TI - Enzyme-Specific Redox Stability and Plasticity in Trained Youth Athletes: Longitudinal Analysis of SOD and GPX. LID - 10.3390/ijms27177813 [doi] LID - 7813 AB - Resting antioxidant enzyme activity in youth athletes may reflect stable individual redox characteristics and developmentally modulated plasticity. This 12-month longitudinal analysis from the MuCAYA(plus) study examined the tracking of superoxide dismutase (SOD) and glutathione peroxidase (GPX) in 69 trained athletes aged 10-17 years. Participants underwent repeated assessments of antioxidant enzyme activity, training exposure, body composition, and hematological parameters. Longitudinal tracking was evaluated using Pearson correlation and intraclass correlation coefficients, while change-score regression models tested whether changes in training exposure, growth-related variables, sex interactions, and hematological parameters predicted changes in SOD or GPX. In exploratory analyses, cluster-based redox phenotype stability was assessed using agreement statistics. Over 12 months, SOD decreased whereas GPX increased. GPX showed substantial tracking (r = 0.714, p < 0.001; ICC = 0.683), while SOD showed no meaningful tracking (r = 0.057, p = 0.644; ICC = 0.053). No statistically supported associations were detected between changes in training-exposure or growth-related measures and enzyme changes. Exploratory erythrocyte-related associations were observed for SOD, whereas leukocyte and platelet changes were unrelated. Cluster-based SOD/GPX phenotype analyses were not robust. These findings are compatible with a comparatively stronger trait-like component for GPX and greater state-like variability for SOD. FAU - Haferanke, Jonas AU - Haferanke J AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Dettenhofer, Maximilian AU - Dettenhofer M AUID- ORCID: 0009-0003-1733-6360 AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Huber, Stefanie AU - Huber S AUID- ORCID: 0009-0002-0757-7681 AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Muhlbauer, Frauke AU - Muhlbauer F AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Baumgartner, Lisa AU - Baumgartner L AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Engl, Tobias AU - Engl T AUID- ORCID: 0000-0002-6251-9532 AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Schulz, Thorsten AU - Schulz T AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Oberhoffer, Renate AU - Oberhoffer R AUID- ORCID: 0000-0002-3166-0488 AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. FAU - Freilinger, Sebastian AU - Freilinger S AUID- ORCID: 0009-0000-3755-6481 AD - Institute of Preventive Pediatrics, Department Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich (TUM), 80809 Munich, Germany. LA - eng GR - 516547656/Deutsche Forschungsgemeinschaft/ PT - Journal Article DEP - 20260831 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - EC 1.15.1.1 (Superoxide Dismutase) RN - EC 1.11.1.9 (Glutathione Peroxidase) RN - 0 (Antioxidants) SB - IM MH - Humans MH - *Superoxide Dismutase/metabolism MH - *Glutathione Peroxidase/metabolism MH - *Athletes MH - Oxidation-Reduction MH - Adolescent MH - Male MH - Longitudinal Studies MH - Female MH - Child MH - Antioxidants/metabolism MH - Body Composition PMC - PMC13566580 OTO - NOTNLM OT - antioxidative capacity OT - glutathione peroxidase OT - oxidative stress OT - pediatric exercise science OT - physical activity OT - redox plasticity OT - superoxide dismutase OT - training adaptation OT - young athletes COIS- The authors declare no conflict of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/31 CRDT- 2026/09/15 03:21 PHST- 2026/07/27 00:00 [received] PHST- 2026/08/28 00:00 [revised] PHST- 2026/08/28 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:21 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - ijms27177813 [pii] AID - ijms-27-07813 [pii] AID - 10.3390/ijms27177813 [doi] PST - epublish SO - Int J Mol Sci. 2026 Aug 31;27(17):7813. doi: 10.3390/ijms27177813. PMID- 42737394 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260915 LR - 20260916 IS - 2304-8158 (Print) IS - 2304-8158 (Electronic) IS - 2304-8158 (Linking) VI - 15 IP - 17 DP - 2026 Sep 5 TI - Neonatal 2'-Fucosyllactose Supplementation Modulates Exploratory Behavior and Hippocampal Synaptic Plasticity in Rats Through Gut Microbiota and Metabolic Remodeling. LID - 10.3390/foods15173151 [doi] LID - 3151 AB - 2'-Fucosyllactose (2'-FL) represents a significant constituent within human milk oligosaccharides, and its benefits for intestinal health and neurodevelopment in infants and young children have been widely recognized. However, the mechanism by which 2'-FL influences early-life behavioral development through the gut-brain axis remains incompletely understood. In this study, we investigated the effects of neonatal 2'-FL supplementation on behavioral development in Sprague-Dawley (SD) rats and explored its potential microbiota-metabolite regulatory mechanisms. After 4 consecutive weeks of oral gavage beginning on postnatal day 2, rats receiving 2'-FL showed significantly increased average movement speed and central-area exploration time in the open field test. From a systemic perspective, 2'-FL lowered blood diamine oxidase (DAO) and D-lactic acid (D-LA) concentrations while elevating colonic mRNA levels of tight junction protein-related genes, consequently enhancing intestinal barrier stability. In addition, 16S rRNA sequencing showed that 2'-FL reshaped the gut microbiota structure and significantly enriched Lactobacillus, Bacteroides, and short-chain fatty acid (SCFA)-associated taxa represented by Lachnospiraceae_NK4A136_group. Untargeted metabolomics revealed that 2'-FL induced systemic metabolic remodeling, characterized by upregulation of the bioactive metabolites dehydroepiandrosterone sulfate (DHEA-S) and deoxycholic acid (DCA), and downregulation of the glucocorticoid-related corticosterone. Western blot validation further showed higher hippocampal protein expression of postsynaptic density protein 95 (PSD95), brain-derived neurotrophic factor (BDNF), and synaptophysin in the 2'-FL group, supporting enhanced synaptic plasticity-related signaling. In summary, neonatal 2'-FL intervention enhanced exploratory behavior and was accompanied by increased hippocampal synaptic plasticity-related protein expression in rats, potentially through coordinated regulation of gut microbiota composition and systemic metabolism. FAU - Yu, Miao AU - Yu M AD - Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. FAU - Wang, Jin AU - Wang J AUID- ORCID: 0000-0002-3312-8831 AD - Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. FAU - Kou, Ruixin AU - Kou R AUID- ORCID: 0009-0005-1613-2360 AD - Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. FAU - Xu, Bingye AU - Xu B AUID- ORCID: 0009-0003-3761-7506 AD - Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. FAU - Zhang, Weiqian AU - Zhang W AD - Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. FAU - Zhang, Ying AU - Zhang Y AD - Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. FAU - Liu, Jingmin AU - Liu J AD - Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. FAU - Wang, Shuo AU - Wang S AD - Tianjin Key Laboratory of Food Science and Health, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. LA - eng GR - 24JCYBJC01770/Natural Science Foundation of Tianjin City/ GR - 63261094/Fundamental Research Funds for the Central Universities, Nankai University/ PT - Journal Article DEP - 20260905 PL - Switzerland TA - Foods JT - Foods (Basel, Switzerland) JID - 101670569 PMC - PMC13565205 OTO - NOTNLM OT - 2'-fucosyllactose OT - behavioral development OT - gut microbiota OT - gut-brain axis OT - neonatal nutrition COIS- The authors declare no conflicts of interest. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/05 CRDT- 2026/09/15 03:21 PHST- 2026/07/30 00:00 [received] PHST- 2026/08/31 00:00 [revised] PHST- 2026/09/03 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:21 [entrez] PHST- 2026/09/05 00:00 [pmc-release] AID - foods15173151 [pii] AID - foods-15-03151 [pii] AID - 10.3390/foods15173151 [doi] PST - epublish SO - Foods. 2026 Sep 5;15(17):3151. doi: 10.3390/foods15173151. PMID- 42736919 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260915 LR - 20260916 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 17 DP - 2026 Sep 1 TI - A CREATE-Based Educational Intervention to Improve Evidence-Based Practice Competencies in a Low-Income Country: A Feasibility Pilot Study. LID - 10.3390/healthcare14172763 [doi] LID - 2763 AB - BACKGROUND: Evidence-based practice (EBP) competencies remain limited in many low-income countries, where access to research training is often constrained by limited educational resources and humanitarian crises. This study evaluated the feasibility and preliminary effectiveness of a CREATE-based teaching strategy to improve EBP competencies among nurses and nursing students in Sudan. METHODS: A quasi-experimental pre-post study without a control group was conducted among 29 participants (17 registered nurses and 12 nursing students) at Comboni College, Port Sudan. The intervention consisted of a 40 h synchronous online educational program based on the CREATE framework, integrating interactive lectures, practical group exercises, teach-back activities, and the collaborative development of an evidence-based Kangaroo Mother Care protocol. EBP competencies were assessed before and after the intervention using the EBP-COQ and EBP-COQ Prof(c) questionnaires. Paired-sample t-tests were used to compare pre- and post-intervention scores. RESULTS: Nursing students demonstrated significant improvements in knowledge (p = 0.009), attitudes (p = 0.015), and overall EBP competency (p = 0.006), whereas changes in self-reported skills were not significant. Registered nurses showed significant improvements in knowledge (p < 0.001), skills (p < 0.001), and overall EBP competency (p < 0.001), while changes in attitudes and EBP utilization were not statistically significant. CONCLUSIONS: This pilot study suggests that a CREATE-based teaching strategy delivered through synchronous distance learning is feasible and may improve EBP competencies among nurses and nursing students in Sudan, despite the challenges of a resource-constrained and conflict-affected setting. Larger controlled studies are needed to confirm these findings and evaluate long-term educational and clinical outcomes. FAU - Marcomini, Ilaria AU - Marcomini I AUID- ORCID: 0000-0001-8096-0199 AD - Center for Nursing Research and Innovation, Faculty of Medicine and Surgery, Vita-Salute University, 20132 Milan, Italy. FAU - Buzzi, Federica AU - Buzzi F AUID- ORCID: 0000-0002-6470-9436 AD - IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. FAU - Poliani, Andrea AU - Poliani A AUID- ORCID: 0000-0002-6714-1057 AD - Center for Nursing Research and Innovation, Faculty of Medicine and Surgery, Vita-Salute University, 20132 Milan, Italy. FAU - Chiodi Daelli, Federico AU - Chiodi Daelli F AD - Italian Association for Solidarity Among Peoples (AISPO), 20132 Milan, Italy. FAU - Ciceri, Fabio AU - Ciceri F AUID- ORCID: 0000-0003-0873-0123 AD - IRCCS San Raffaele Scientific Institute, 20132 Milan, Italy. FAU - Naranjo Alcaide, Jorge Carlos AU - Naranjo Alcaide JC AUID- ORCID: 0000-0002-4287-5900 AD - Comboni College of Science and Technology, Port Sudan 33311, Sudan. FAU - Omer, Halima Ibrahim Malik Ali AU - Omer HIMA AUID- ORCID: 0000-0002-7097-0964 AD - Comboni College of Science and Technology, Port Sudan 33311, Sudan. FAU - Rosa, Debora AU - Rosa D AUID- ORCID: 0000-0002-1440-3092 AD - Center for Nursing Research and Innovation, Faculty of Medicine and Surgery, Vita-Salute University, 20132 Milan, Italy. FAU - Villa, Giulia AU - Villa G AUID- ORCID: 0000-0001-7429-0504 AD - Center for Nursing Research and Innovation, Faculty of Medicine and Surgery, Vita-Salute University, 20132 Milan, Italy. FAU - Zanuso, Rebecca AU - Zanuso R AD - Italian Association for Solidarity Among Peoples (AISPO), 20132 Milan, Italy. FAU - Marhoom, Mohja AU - Marhoom M AUID- ORCID: 0000-0003-3197-5225 AD - Comboni College of Science and Technology, Port Sudan 33311, Sudan. FAU - Manara, Duilio F AU - Manara DF AUID- ORCID: 0000-0001-5182-6994 AD - Center for Nursing Research and Innovation, Faculty of Medicine and Surgery, Vita-Salute University, 20132 Milan, Italy. LA - eng GR - Italian Association for Solidarity among Peoples (AISPO)/ PT - Journal Article DEP - 20260901 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13565826 OTO - NOTNLM OT - Sudan OT - evidence-based practice OT - low-income countries OT - maternal and child health OT - nursing education OT - remote education COIS- The authors declare no conflicts of interest, and the funder had no role in study design, data collection, data analysis or interpretation of results. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/01 CRDT- 2026/09/15 03:20 PHST- 2026/07/06 00:00 [received] PHST- 2026/08/23 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:20 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - healthcare14172763 [pii] AID - healthcare-14-02763 [pii] AID - 10.3390/healthcare14172763 [doi] PST - epublish SO - Healthcare (Basel). 2026 Sep 1;14(17):2763. doi: 10.3390/healthcare14172763. PMID- 42736809 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20261010 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 37 DP - 2026 Sep 11 TI - Continuous age-dependent centile curves and preliminary reference intervals for renal biomarkers and electrolytes in healthy Kenyan children under five years: A single-center cross-sectional study. PG - e50653 LID - 10.1097/MD.0000000000050653 [doi] LID - e50653 AB - Renal biomarkers change rapidly in early childhood, but pediatric reference intervals used in African laboratories are often extrapolated from non-African populations and discrete age partitions. This study derived continuous age-dependent centile curves and preliminary reference intervals for body mass index (BMI), serum creatinine, urea, and electrolytes in healthy Kenyan children aged 0 to 60 months. In this cross-sectional study, 176 children (90 males, 86 females) were systematically recruited at Kitui County Referral Hospital between June 2024 and February 2025. Children underwent clinical screening, World Health Organization-standard anthropometry, and morning fasting venous blood sampling. Creatinine and urea were measured using isotope-dilution mass spectrometry-traceable enzymatic assays, and electrolytes by direct ion-selective electrode. Centiles (2.5th, 50th, 97.5th) were estimated non-parametrically with 90% bootstrap confidence intervals, and continuous age trends modeled using generalized additive models for location, scale, and shape or quantile regression. BMI showed modest age-related variation, with median values rising from 15.8 kg/m2 (2.5th-97.5th: 11.4-20.2) at 0 to 11 months to 16.5 kg/m2 (10.1-23.0) at 48 to 60 months, with dispersion narrowing after age 2. Median creatinine rose steeply in infancy and more gradually thereafter, from 17.4 to 31.2 micromol/L. Urea increased gradually from a median of 2.59 to 3.63 mmol/L, with overlapping centile limits across adjacent strata. Electrolytes were tightly regulated and largely age-invariant: sodium ranged from 135 to 147 mmol/L (median ~141), potassium 3.6 to 5.7 mmol/L (median declining from 4.9 to 4.5), and chloride 100 to 111 mmol/L (median ~105-106). Sex-specific partitions were supported only in early life (BMI in infancy, creatinine in toddlers); correlations between anthropometric z-scores and biomarkers were weak (|rho| < 0.15; P > .10). These continuous centile curves provide the first preliminary age-dependent reference estimates for renal biomarkers in Kenyan children under 5, showing rapid early renal maturation alongside stable electrolyte homeostasis. As this cross-sectional design cannot capture within-subject variation, larger multicenter and longitudinal studies are needed to confirm these trajectories, refine intervals, and develop age-dependent z-score calculators for clinical use. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Nganda, Brian AU - Nganda B AUID- ORCID: 0009-0006-5981-1424 AD - Department of Medical Laboratory Sciences, School of Biomedical Sciences, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya. FAU - Karanja, Peter AU - Karanja P AD - Department of Medical Laboratory Sciences, School of Biomedical Sciences, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Kenya. FAU - Muna, Kennedy AU - Muna K AD - Department of Medical Laboratory Sciences, School Pure, Applied, and Health Sciences, Murang'a University of Technology, Murang'a, Kenya. FAU - Moriasi, Gervason AU - Moriasi G AUID- ORCID: 0000-0001-5604-9987 AD - Department of Biochemistry, Microbiology, and Biotechnology, School of Pure and Applied Sciences, Kenyatta University, Nairobi, Kenya. AD - Department of Medical Biochemistry, Medical School, Mount Kenya University, Thika, Kenya. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - 0 (Biomarkers) RN - 0 (Electrolytes) RN - 8W8T17847W (Urea) RN - AYI8EX34EU (Creatinine) SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Kenya MH - Male MH - Infant MH - *Biomarkers/blood MH - *Electrolytes/blood MH - Reference Values MH - *Urea/blood MH - *Creatinine/blood MH - Child, Preschool MH - Body Mass Index MH - Infant, Newborn MH - Age Factors MH - *Kidney PMC - PMC13574458 OTO - NOTNLM OT - diagnostic accuracy OT - generalized additive models OT - pediatric reference intervals OT - renal function biomarkers COIS- The authors have no funding and conflicts of interest to declare. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/11 CRDT- 2026/09/15 03:20 PHST- 2026/01/02 00:00 [received] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:20 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 00005792-202609110-00094 [pii] AID - MD-D-25-18841 [pii] AID - 10.1097/MD.0000000000050653 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Sep 11;105(37):e50653. doi: 10.1097/MD.0000000000050653. PMID- 42736733 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20261010 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 37 DP - 2026 Sep 11 TI - A machine learning model integrating radiomics and clinical factors to predict recurrence risk after rehabilitation in lumbar disc herniation. PG - e50454 LID - 10.1097/MD.0000000000050454 [doi] LID - e50454 AB - This study aimed to construct and internally validate a machine learning model integrating radiomics features and clinical factors to predict post-rehabilitation recurrence risk in patients with lumbar disc herniation (LDH). In this single-center retrospective cohort study, 260 adults aged 18 to 70 years with LDH who completed standardized rehabilitation were analyzed (78 with recurrence and 182 without recurrence). Radiomics features were extracted separately from sagittal T1-weighted, sagittal T2-weighted, and axial T2-weighted magnetic resonance imaging, standardized, concatenated across sequences, and reduced using least absolute shrinkage and selection operator regression. Three logistic regression models were developed: radiomics-only, clinical plus rehabilitation, and combined models. A stratified 70/30 split provided internal validation; receiver operating characteristic curves, calibration analysis, decision curve analysis, and risk stratification were used to evaluate performance. A separate multivariable logistic regression analysis was used to identify clinically interpretable predictors. Age, body mass index, disc height index, improvement in the Oswestry Disability Index, diabetes, Modic changes, and poor rehabilitation adherence differed significantly between the recurrence and non-recurrence groups (all P < .05). The combined model demonstrated the best predictive performance, with an area under the curve (AUC) of 0.85 (95% confidence interval: 0.78-0.91), outperforming the radiomics model (AUC = 0.78) and the clinical model (AUC = 0.76). The calibration curve showed strong agreement between predicted and observed recurrence, and decision curve analysis indicated superior net clinical benefit across a wide range of thresholds. Based on predicted probabilities, patients were stratified into low- (<20%), intermediate- (20%-40%), and high-risk (>40%) groups, with recurrence rates of 15.0%, 30.0%, and 66.0%, respectively (P < .001). Multivariable logistic regression identified disc height index (odds ratio [OR] = 1.80), Oswestry Disability Index improvement (OR = 0.65), poor rehabilitation adherence (OR = 2.50), diabetes (OR = 2.10), and Modic changes (OR = 1.90) as independent predictors of recurrence. Integrating multisequence weighted magnetic resonance imaging radiomics with clinical and rehabilitation variables improved internal prediction of post-rehabilitation recurrence in LDH. The combined model may support risk-adapted rehabilitation intensity and follow-up, but it requires prospective, multicenter external validation before routine clinical use. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Qi, Yanhong AU - Qi Y AD - Medical Department, Beidaihe Rest and Recuperation Center of the Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. FAU - Feng, Yifei AU - Feng Y AD - Department of Medical Imaging, Beidaihe Rest and Recuperation Center of the Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. FAU - Xing, Xiaoyue AU - Xing X AD - Department of Medical Imaging, Beidaihe Rest and Recuperation Center of the Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. FAU - Wang, Zhe AU - Wang Z AD - Special Care Department, Beidaihe Rehabilitation and Recuperation Center, Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. FAU - Yang, Yuwei AU - Yang Y AD - Medical Department, Beidaihe Rest and Recuperation Center of the Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. FAU - Zhang, Lin AU - Zhang L AD - Medical Department, Beidaihe Rest and Recuperation Center of the Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. FAU - Yu, Weiguo AU - Yu W AUID- ORCID: 0009-0000-1821-7919 AD - Department of Medical Imaging, Beidaihe Rest and Recuperation Center of the Joint Logistics Support Force, PLA, Beidaihe City, Hebei Province, China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Radiomics MH - *Intervertebral Disc Displacement/rehabilitation/diagnostic imaging MH - *Machine Learning MH - Middle Aged MH - Adult MH - Retrospective Studies MH - Recurrence MH - *Lumbar Vertebrae/diagnostic imaging MH - Female MH - Magnetic Resonance Imaging/methods MH - Male MH - Predictive Learning Models MH - Aged MH - Logistic Models MH - ROC Curve MH - Young Adult MH - Adolescent MH - Risk Factors PMC - PMC13574428 OTO - NOTNLM OT - lumbar disc herniation OT - machine learning OT - predictive model OT - radiomics OT - recurrence OT - rehabilitation COIS- The authors have no funding and conflicts of interest to declare. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/11 CRDT- 2026/09/15 03:20 PHST- 2025/12/02 00:00 [received] PHST- 2026/08/13 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:20 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 00005792-202609110-00017 [pii] AID - MD-D-25-17232 [pii] AID - 10.1097/MD.0000000000050454 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Sep 11;105(37):e50454. doi: 10.1097/MD.0000000000050454. PMID- 42736577 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260915 LR - 20260916 IS - 2052-1847 (Print) IS - 2052-1847 (Electronic) IS - 2052-1847 (Linking) VI - 18 IP - 1 DP - 2026 Aug 18 TI - Effectiveness of virtual reality-based balance training in primary school children: a randomized controlled trial. LID - 10.1186/s13102-026-02006-y [doi] LID - 415 AB - Balance and coordination are fundamental for children's motor development and injury prevention, yet sedentary lifestyles have contributed to their decline. Conventional balance training can be effective, but maintaining children's engagement remains challenging. Virtual reality (VR)-based programs provide immersive and gamified practice and may offer an alternative way to deliver balance- and coordination-related training in schools. This six-week randomized controlled trial compared immersive VR-based training with conventional training in 129 primary school students (VR: n = 64; control: n = 65). Participants trained three times per week for 30 min per session. Balance and coordination were assessed pre- and post-intervention using the Y-Balance Test (YBT composite score) as the primary dynamic-balance outcome, alongside single-leg stance with eyes closed (SLST-EC) and a 1-minute rope-skipping test. Both groups showed significant pre-post improvements across all outcomes (all p < 0.001), but within-group rope-skipping changes were not reliably interpretable as training effects because of likely test-retest familiarization, and SLST-EC changes were constrained by ceiling effects. Between-group comparisons of change scores showed no statistically significant differences for DeltaYBT, DeltaSLST-EC, or Deltarope skipping (all p > 0.05). An ANCOVA adjusting for baseline YBT also showed no group effect on post-intervention YBT (p = 0.442). Overall, immersive VR did not show a statistically significant advantage over conventional training matched for scheduled frequency and session duration in this six-week school-based trial. Trial registration: ISRCTN Registry, ISRCTN37850916, registered on 30 June 2026. Retrospectively registered. CI - (c) 2026. The Author(s). FAU - Zhang, Hongfei AU - Zhang H AUID- ORCID: 0009-0003-7134-7757 AD - Gdansk University of Physical Education and Sport, Gdansk, 80-336, Poland. FAU - Hu, Wenjun AU - Hu W AD - Gdansk University of Physical Education and Sport, Gdansk, 80-336, Poland. FAU - Kortas, Jakub AU - Kortas J AD - Gdansk University of Physical Education and Sport, Gdansk, 80-336, Poland. jakub.kortas@awf.gda.pl. LA - eng PT - Journal Article DEP - 20260818 PL - England TA - BMC Sports Sci Med Rehabil JT - BMC sports science, medicine & rehabilitation JID - 101605016 PMC - PMC13573351 OTO - NOTNLM OT - Balance training OT - Child health promotion OT - Exercise intervention OT - Motor coordination OT - Virtual reality COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Shanxi Engineering Vocational College (Ethics approval No. SEVC-2025-063). Written informed consent was obtained from the parents or legal guardians of all participating children before participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/08/18 CRDT- 2026/09/15 03:10 PHST- 2025/12/12 00:00 [received] PHST- 2026/08/14 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:10 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - 10.1186/s13102-026-02006-y [pii] AID - 2006 [pii] AID - 10.1186/s13102-026-02006-y [doi] PST - epublish SO - BMC Sports Sci Med Rehabil. 2026 Aug 18;18(1):415. doi: 10.1186/s13102-026-02006-y. PMID- 42736564 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260915 LR - 20260917 IS - 2052-1847 (Print) IS - 2052-1847 (Electronic) IS - 2052-1847 (Linking) VI - 18 IP - 1 DP - 2026 Sep 12 TI - Characterization of eccentric hamstring strength and inter-limb asymmetry profiles in national-level youth male soccer players. LID - 10.1186/s13102-026-01980-7 [doi] LID - 416 AB - BACKGROUND: Eccentric hamstring strength and inter-limb asymmetry are commonly monitored in youth football; however, evidence comparing their magnitude and directional consistency across age categories remains limited. This study compared eccentric hamstring strength and inter-limb asymmetry magnitude between national-level U12 and U18 male footballers and assessed within-cohort agreement in stronger-limb classification. METHODS: In this cross-sectional study, 63 national-level male youth footballers were included: 35 U12 players aged approximately 12.0-12.9 years and 28 U18 players aged approximately 17.3-18.9 years. Participants completed repeated maximal bilateral Nordic Hamstring Exercise trials. Absolute peak force (PF), body mass-normalized peak force (RPF), inter-limb asymmetry magnitude, and stronger-limb classification were assessed. Trial-to-trial reliability was evaluated using coefficients of variation and intraclass correlation coefficients. Between-cohort differences in PF and RPF were examined using independent-samples t-tests, whereas the Mann-Whitney U test was used for inter-limb asymmetry. Hedges' g quantified between-cohort effect sizes, and Cohen's kappa assessed agreement in stronger-limb classification across trials. RESULTS: The U18 cohort demonstrated greater absolute PF (383.1 +/- 37.8 vs. 230.7 +/- 46.6 N; g = 3.51, p < 0.001) and RPF (5.1 +/- 0.5 vs. 4.5 +/- 0.6 N.kg(-)(1); g = 1.01, p < 0.001) than the U12 cohort. Inter-limb asymmetry was greater in U12 players (4.5 +/- 2.3%) than in U18 players (3.3 +/- 2.8%; g = - 0.48, p = 0.036). The U12 cohort demonstrated substantial within-cohort agreement in stronger-limb classification (kappa = 0.860, p < 0.001), whereas no evidence of agreement was observed in the U18 cohort (kappa = -0.143, p = 0.450). CONCLUSIONS: National-level U18 male footballers exhibited greater absolute and body mass-normalized eccentric hamstring strength and lower mean inter-limb asymmetry than U12 players. The U12 cohort showed substantial within-cohort agreement in stronger-limb classification, whereas no evidence of agreement was observed in the U18 cohort. Strength magnitude, asymmetry magnitude, and asymmetry direction should therefore be interpreted as complementary monitoring indicators, preferably alongside repeated assessments rather than as interchangeable measures. CI - (c) 2026. The Author(s). FAU - Wang, Jiaxin AU - Wang J AD - School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, China. FAU - Jiang, Dongting AU - Jiang D AD - School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, China. AD - School of Coaching, Shanghai University of Sport, Shanghai, 200438, China. FAU - Bishop, Chris AU - Bishop C AD - Faculty of Science and Technology, London Sport Institute, London, NW4 1RL, UK. FAU - Zhou, Changjing AU - Zhou C AD - School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, China. FAU - Lyu, Mengde AU - Lyu M AD - School of Biomedical Science and Health, Royal Melbourne Institute of Technology University, Melbourne, Australia. FAU - Zheng, Hang AU - Zheng H AD - School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, China. FAU - Tang, Yue AU - Tang Y AD - School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, China. FAU - Bi, Zhiyuan AU - Bi Z AD - School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, China. FAU - Li, Yongming AU - Li Y AUID- ORCID: 0000-0001-9654-0199 AD - School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, China. liyongming@sus.edu.cn. AD - China Institute of Sport Science, Beijing, 100061, China. liyongming@sus.edu.cn. AD - School of Coaching, Shanghai University of Sport, Shanghai, 200438, China. liyongming@sus.edu.cn. LA - eng PT - Journal Article DEP - 20260912 PL - England TA - BMC Sports Sci Med Rehabil JT - BMC sports science, medicine & rehabilitation JID - 101605016 PMC - PMC13576348 OTO - NOTNLM OT - Age-group comparison OT - Body mass normalization OT - Nordic hamstring exercise OT - Peak force OT - Stronger-limb consistency OT - Trial-to-trial reliability COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Shanghai University of Sport (Approval No. 102772025RT222). Written informed consent was obtained from adult participants and from the parents or legal guardians of all minor participants before enrollment. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/12 CRDT- 2026/09/15 03:05 PHST- 2026/05/31 00:00 [received] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 03:05 [entrez] PHST- 2026/09/12 00:00 [pmc-release] AID - 10.1186/s13102-026-01980-7 [pii] AID - 1980 [pii] AID - 10.1186/s13102-026-01980-7 [doi] PST - epublish SO - BMC Sports Sci Med Rehabil. 2026 Sep 12;18(1):416. doi: 10.1186/s13102-026-01980-7. PMID- 42736550 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260922 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Sep 10 TI - Effectiveness of a digi-physical tool and working method for paediatric obesity treatment in Abu Dhabi: a non-inferiority intervention study using an external historical comparator. LID - 10.1186/s12887-026-07623-7 [doi] LID - 868 AB - BACKGROUND: Effective paediatric obesity treatment requires high intensity, scalable interventions. A digi-physical tool for paediatric obesity treatment has shown positive results in Stockholm, Sweden. This study evaluates whether the same treatment method is effective in a different cultural setting. METHODS: This non-inferiority intervention study, using an external historical comparator, included 60 consecutively recruited children aged 6-15.9 years with obesity who initiated treatment at Sheikh Shakhbout Medical City in Abu Dhabi between June and December 2023. Patients were treated with Evira, a digi-physical tool and working method enabling high intensity individualized care, real-time monitoring, and interactive patient-clinician communication. The primary outcome was BMI z-score change at 26 weeks. Non-inferiority was assessed using a predefined margin of 0.10 BMI z-score, with outcomes compared to a prior published trial in Stockholm (n = 107). RESULTS: A total of 112 children were included in the analysis (Abu Dhabi cohort, n = 35; Stockholm cohort, n = 77). The adjusted mean change in BMI z-score was - 0.20 (95% CI: - 0.28, - 0.12) in the Abu Dhabi cohort and - 0.20 (- 0.26, - 0.14) in the Stockholm cohort (p = 0.88). Non-inferiority was confirmed, (predefined margin 0.10 was not exceeded). A clinically significant BMI z-score reduction (>/= 0.20 units) was achieved by 45.7% of participants in Abu Dhabi and 36.4% in Stockholm (p = 0.35). Non-retention rates at 26 weeks were 41.7% vs. 28.0%, respectively (p = 0.07). CONCLUSIONS: The findings provide promising evidence that treatment outcomes achieved with the digi-physical treatment tool were comparable in the Abu Dhabi and Stockholm cohorts, supporting its feasibility in a second cultural and healthcare setting. CI - (c) 2026. The Author(s). FAU - Lindberg, Louise AU - Lindberg L AD - Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden. louise.lindberg@ki.se. AD - Evira AB, Triewaldsgrand 2, Stockholm, Sweden. louise.lindberg@ki.se. FAU - Hassan Beck, Reem AU - Hassan Beck R AD - Paediatric Endocrine Division, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates. FAU - Danielsson, Pernilla AU - Danielsson P AD - Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden. FAU - Nielsen, Timmy AU - Nielsen T AD - Evira AB, Triewaldsgrand 2, Stockholm, Sweden. FAU - Abdalla, Asmahan AU - Abdalla A AD - Paediatric Endocrine Division, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates. FAU - Ekstedt, Peter AU - Ekstedt P AD - Swedish Health, Dubai, United Arab Emirates. FAU - Chaturvedi, Deepti AU - Chaturvedi D AD - Paediatric Endocrine Division, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates. FAU - Al Qahtani, Nabras AU - Al Qahtani N AD - Paediatric Endocrine Division, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates. FAU - Marcus, Claude AU - Marcus C AD - Division of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden. AD - Evira AB, Triewaldsgrand 2, Stockholm, Sweden. FAU - Deeb, Asma AU - Deeb A AD - Paediatric Endocrine Division, Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates. AD - Faculty of Health & Science, Khalifa University, Abu Dhabi, United Arab Emirates. LA - eng PT - Equivalence Trial PT - Journal Article DEP - 20260910 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - *Pediatric Obesity/therapy MH - Adolescent MH - Sweden MH - Body Mass Index MH - Treatment Outcome PMC - PMC13573347 OTO - NOTNLM OT - Digital health OT - Home-weighing OT - Non-inferiority intervention study OT - Paediatric obesity OT - Treatment outcome COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the declaration of Helsinki and approved by the Institution Review Board of SSMC, Abu Dhabi (SSMCREC-395) as well as the Stockholm Ethics Committee (approval no. 2018/1413-31, amendment 2024-06085-02). The study is retrospectively registered on Clinicaltrials.gov (ID: NCT06665893) 2024-10-29. Eligible patients were invited to participate, after receiving both oral and written information from one of the study clinicians. Informed consent was obtained from the parents or legal guardians. Consent for publication: Not applicable. Competing interests: LL and TN are employees of, and have share rights in, Evira AB. CM is a board member and shareholder of Evira AB. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:37 PMCR- 2026/09/10 CRDT- 2026/09/15 02:57 PHST- 2025/04/08 00:00 [received] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/15 05:37 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 02:57 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - 10.1186/s12887-026-07623-7 [pii] AID - 7623 [pii] AID - 10.1186/s12887-026-07623-7 [doi] PST - epublish SO - BMC Pediatr. 2026 Sep 10;26(1):868. doi: 10.1186/s12887-026-07623-7. PMID- 42736520 OWN - NLM STAT- Publisher LR - 20260915 IS - 1933-7205 (Electronic) IS - 1933-7191 (Linking) DP - 2026 Sep 14 TI - Circulating Fatty Acid-Binding Protein 4 (FABP4) in Adolescents with Polycystic Ovary Syndrome: Metabolic Correlates and Diagnostic Performance. LID - 10.1007/s43032-026-02189-2 [doi] AB - To compare circulating fatty acid-binding protein 4 (FABP4) concentrations in adolescents with polycystic ovary syndrome (PCOS) and controls, examine its metabolic correlates, and evaluate its diagnostic performance. This prospective observational study included 88 adolescents (44 PCOS, 44 controls) aged 10-19 years. PCOS was diagnosed using 2023 ESHRE/ASRM criteria. Clinical, anthropometric, and biochemical parameters were assessed. Serum FABP4 was measured via ELISA. Statistical analyses included multivariable linear regression, Firth's penalized logistic regression, and receiver operating characteristic (ROC) curves. Median FABP4 levels were significantly higher in adolescents with PCOS compared to controls (5.74 vs. 3.59 ng/mL, p < 0.001). Multivariable linear regression demonstrated that PCOS status, body mass index (BMI), and insulin resistance (HOMA-IR) associated with higher FABP4 concentrations. Multivariable logistic regression identified free androgen index (FAI) and FABP4 as variables independently associated with PCOS. ROC analysis showed FABP4 (> 4.08 ng/mL) yielded an area under the curve (AUC) of 0.849 (81.8% sensitivity, 75.0% specificity). The combination of FABP4 and FAI improved model discrimination compared with FAI alone (DeltaAUC = 0.133, p = 0.001), and this improvement remained significant after BMI adjustment. Circulating FABP4 is elevated in adolescents with PCOS and is associated with PCOS status, BMI, and insulin resistance. In this cohort, FABP4 provided complementary metabolic information when interpreted alongside FAI; however, BMI-matched, body composition-characterized, and externally validated studies are needed before FABP4 can be considered a clinically generalizable adjunctive biomarker in adolescent PCOS. CI - (c) 2026. The Author(s), under exclusive licence to Society for Reproductive Investigation. FAU - Codal, Bahadir AU - Codal B AUID- ORCID: 0000-0003-0044-9820 AD - Department of Obstetrics and Gynecology Bursa, Nev Anadolu Hospital, Nev Anadolu Hospital, 16110, Bursa, Turkiye. bahadrcodal@gmail.com. FAU - Kurt, Ahmet AU - Kurt A AUID- ORCID: 0000-0001-8402-5675 AD - Department of Obstetrics and Gynecology, Gemlik State Hospital, Bursa, Turkiye. FAU - Kaplan, Hacer AU - Kaplan H AUID- ORCID: 0009-0005-9240-4065 AD - Department of Obstetrics and Gynecology, Etlik City Hospital, Ankara, Turkiye. FAU - Cakir, Ayberk AU - Cakir A AUID- ORCID: 0000-0001-5749-4556 AD - Department of Obstetrics and Gynecology, Acibadem University Atakent Hospital, Istanbul, Turkiye. FAU - Hizli, Burak AU - Hizli B AUID- ORCID: 0009-0004-6060-1761 AD - School of Medicine, Department of Obstetrics and Gynecology, Usak University, Usak, Turkiye. FAU - Ozler, Mustafa Rasit AU - Ozler MR AUID- ORCID: 0000-0001-5911-6786 AD - Department of Perinatology, Bursa City Hospital, Bursa, Turkiye. LA - eng PT - Journal Article DEP - 20260914 PL - United States TA - Reprod Sci JT - Reproductive sciences (Thousand Oaks, Calif.) JID - 101291249 SB - IM OTO - NOTNLM OT - Adipokines OT - Adolescent OT - Biomarkers OT - Fatty acid-binding protein 4 OT - Hyperandrogenism OT - Insulin resistance OT - Polycystic ovary syndrome COIS- Declarations. Ethics Approval and Consent to Participate: The study protocol was approved by the Acibadem Mehmet Ali Aydinlar University Medical Research Evaluation Commission (ATADEK) (Approval No: ATADEK-2026-01/07). The study was conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from all participants and their legal guardians prior to enrollment. Consent for Publication: The authors declare that they agree to publication. Conflict of interest: The authors declare that there is no conflict of interest regarding the publication of this article. No financial or personal relationships exist that could inappropriately influence or bias the content of the work. EDAT- 2026/09/15 05:36 MHDA- 2026/09/15 05:36 CRDT- 2026/09/15 02:51 PHST- 2026/03/17 00:00 [received] PHST- 2026/08/15 00:00 [accepted] PHST- 2026/09/15 05:36 [medline] PHST- 2026/09/15 05:36 [pubmed] PHST- 2026/09/15 02:51 [entrez] AID - 10.1007/s43032-026-02189-2 [pii] AID - 10.1007/s43032-026-02189-2 [doi] PST - aheadofprint SO - Reprod Sci. 2026 Sep 14. doi: 10.1007/s43032-026-02189-2. PMID- 42736084 OWN - NLM STAT- MEDLINE DCOM- 20261028 LR - 20261028 IS - 1933-2874 (Print) IS - 1876-4789 (Linking) VI - 20 IP - 10 DP - 2026 Oct TI - Beyond conventional lipid panel: Estimated small dense and triglyceride-rich LDL cholesterol are associated with prediabetes independently of obesity in adolescents. PG - 2255-2266 LID - S1933-2874(26)00493-9 [pii] LID - 10.1016/j.jacl.2026.08.017 [doi] AB - BACKGROUND: Childhood obesity is strongly associated with insulin resistance and atherogenic dyslipidemia. Novel lipid indices such as small dense low-density lipoprotein cholesterol (sdLDL-C) and triglyceride-rich LDL (LDL-TG), along with the triglyceride-glucose (TyG) index, may improve early detection of metabolic risk, but their role in adolescents remains unclear. OBJECTIVE: To evaluate the association of calculated lipid indices (sdLDL-C, LDL-TG) and the TyG index with adiposity and prediabetes, and to assess their discriminative performance beyond conventional lipid parameters. METHODS: We conducted a retrospective cross-sectional study including 1302 adolescents aged 10 to 19 years. Participants were classified by body mass index (BMI) category. Calculated lipid indices and TyG were derived from routine laboratory data. Multinomial logistic regression assessed associations with overweight and obesity. A matched case-control analysis (n = 154 pairs) evaluated independent associations with prediabetes, including a secondary model matched for LDL-C. Discriminative ability was assessed using receiver operating characteristic curves. RESULTS: All metabolic markers increased progressively with BMI (P < 0.001). The TG/high-density lipoprotein cholesterol (HDL-C) ratio showed the strongest association with obesity (standardized OR 7.17). In matched analyses, TyG, sdLDL-C, LDL-TG, and TG/HDL-C were independently associated with prediabetes. In the LDL-C matched model, TyG remained strongly associated (P < 0.001), while sdLDL-C and LDL-TG retained independent associations. TyG showed the highest discriminative ability for prediabetes (areas under the curve [AUC] 0.678); sdLDL-C, LDL-TG, and TG/HDL-C showed comparable, more modest discriminative power (AUC 0.586-0.601). CONCLUSION: Calculated lipid indices capture early atherogenic lipoprotein remodeling in adolescents, independently of adiposity and LDL-C. While TyG is the strongest marker of glucose dysregulation, lipid-derived indices provide complementary information on cardiometabolic risk. These accessible markers may provide complementary, independent information for early risk stratification using routine laboratory data. CI - Copyright (c) 2026 National Lipid Association. Published by Elsevier Inc. All rights reserved. FAU - Cardozo Madaf, Abi AU - Cardozo Madaf A AD - Departamento de Bioquimica Clinica, Bioquimica Clinica 1, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky); Instituto de Fisiopatologia y Bioquimica Clinica (INFIBIOC), Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky). FAU - Oliveras Barri, Carola AU - Oliveras Barri C AD - Departamento de Bioquimica Clinica, Bioquimica Clinica 1, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky); Instituto de Fisiopatologia y Bioquimica Clinica (INFIBIOC), Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky). FAU - Gomez, Maria Eugenia AU - Gomez ME AD - Departamento de Bioquimica Clinica, Bioquimica Clinica 1, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky); Instituto de Fisiopatologia y Bioquimica Clinica (INFIBIOC), Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky). FAU - Perazzi, Beatriz AU - Perazzi B AD - Departamento de Bioquimica Clinica, Bioquimica Clinica 1, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky); Instituto de Fisiopatologia y Bioquimica Clinica (INFIBIOC), Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Universidad de Buenos Aires, Buenos Aires, Argentina (Perazzi and Berg). FAU - Berg, Gabriela AU - Berg G AD - Departamento de Bioquimica Clinica, Bioquimica Clinica 1, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky); Instituto de Fisiopatologia y Bioquimica Clinica (INFIBIOC), Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky); Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Universidad de Buenos Aires, Buenos Aires, Argentina (Perazzi and Berg); Programa de control de enfermedades cardiovasculares (PROCORDIS), Fundacion Bioquimica Argentina, Buenos Aires, Argentina (Berg). FAU - Lucero, Diego AU - Lucero D AD - Saha Cardiovascular Research Center, University of Kentucky, Lexington, KY, USA (Lucero); Department of Physiology, University of Kentucky, Lexington, KY, USA (Lucero). FAU - Fernandez Machulsky, Nahuel AU - Fernandez Machulsky N AD - Departamento de Bioquimica Clinica, Bioquimica Clinica 1, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky); Instituto de Fisiopatologia y Bioquimica Clinica (INFIBIOC), Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Buenos Aires, Argentina (Cardozo Madaf, Oliveras Barri, Gomez, Perazzi, Berg, and Fernandez Machulsky). Electronic address: nh.machulsky@docente.ffyb.uba.ar. LA - eng PT - Journal Article DEP - 20260831 PL - United States TA - J Clin Lipidol JT - Journal of clinical lipidology JID - 101300157 RN - 0 (Triglycerides) RN - 0 (Cholesterol, LDL) SB - IM MH - Humans MH - *Prediabetic State/blood/complications MH - Adolescent MH - *Triglycerides/blood MH - Male MH - Female MH - *Cholesterol, LDL/blood MH - Child MH - *Obesity/blood/complications MH - Retrospective Studies MH - Cross-Sectional Studies MH - Young Adult MH - Body Mass Index OTO - NOTNLM OT - Adolescent OT - Insulin resistance OT - Obesity OT - Prediabetes OT - Small dense LDL cholesterol OT - Triglyceride-glucose index OT - Triglyceride-rich LDL COIS- Declaration of competing interest The authors declare that they have no conflict of interest EDAT- 2026/09/15 05:06 MHDA- 2026/10/28 23:26 CRDT- 2026/09/14 21:52 PHST- 2026/04/23 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/10/28 23:26 [medline] PHST- 2026/09/15 05:06 [pubmed] PHST- 2026/09/14 21:52 [entrez] AID - S1933-2874(26)00493-9 [pii] AID - 10.1016/j.jacl.2026.08.017 [doi] PST - ppublish SO - J Clin Lipidol. 2026 Oct;20(10):2255-2266. doi: 10.1016/j.jacl.2026.08.017. Epub 2026 Aug 31. PMID- 42734924 OWN - NLM STAT- MEDLINE DCOM- 20260914 LR - 20260914 IS - 1873-5843 (Electronic) IS - 0887-6177 (Linking) VI - 41 IP - 7 DP - 2026 Sep 9 TI - Characterizing neuropsychological performance and its nutritional, visual, and physiological correlates in children. LID - acag071 [pii] LID - 10.1093/arclin/acag071 [doi] AB - OBJECTIVE: To characterize neuropsychological performance in Ghanaian preadolescent children and examine its associations with demographic, health, nutritional, and visual factors. METHODS: A cross-sectional study was conducted among 290 preadolescent school children (median age: 11.0 years [IQR: 2.0]; range: 8-11 years; 54.8% female) from urban and rural public and private schools in the Ashanti Region of Ghana. Neuropsychological function was assessed using the Cambridge Neuropsychological Test Automated Battery, covering memory, executive function, attention, and psychomotor domains (minimum analytical sample: n = 150). Spearman's rank correlations assessed convergent validity and domain-specific independence. Associations between participant characteristics and cognitive performance were examined using multivariable linear regression, with Benjamini-Hochberg false discovery rate (FDR) correction applied across all regression tests. Statistical significance was defined as an FDR-adjusted q < 0.05, whereas both unadjusted p-values and adjusted q-values were reported for transparency. RESULTS: Cognitive performance exhibited a predominantly modular structure, characterized by strong within-task coherence and limited cross-domain integration. Males performed better than females on visual learning and psychomotor speed tasks, particularly Paired Associates Learning and movement reaction time measures (p < .05), whereas simple reaction time did not differ between sexes (p > .05). Following Benjamini-Hochberg FDR correction, no associations between cognitive performance and demographic, health, nutritional, or visual factors remained statistically significant. CONCLUSION: Neuropsychological functioning in Ghanaian preadolescent children appears to be predominantly modular, with limited evidence that demographic, health, nutritional, or visual factors are independently associated with cognitive performance after correction for multiple comparisons. CI - (c) The Author(s) 2026. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Osei Duah Junior, Isaiah AU - Osei Duah Junior I AUID- ORCID: 0000-0003-4501-8602 AD - Department of Optometry and Visual Science, College of Science, PMB, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. AD - Department of Psychology, John R. and Kathy R. Hairston College of Health and Human Sciences, North Carolina Agricultural and Technical State University, Greensboro, NC 27411, United States of America. FAU - Ashon, Nana Aba Senuwah AU - Ashon NAS AUID- ORCID: 0009-0009-4618-8321 AD - Department of Optometry and Visual Science, College of Science, PMB, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Ofori-Asare, Wendy AU - Ofori-Asare W AUID- ORCID: 0009-0001-2401-9561 AD - Department of Optometry and Visual Science, College of Science, PMB, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Johnson, Elizabeth J AU - Johnson EJ AUID- ORCID: 0000-0002-8508-0032 AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, United States of America. FAU - Amoako, Mary AU - Amoako M AUID- ORCID: 0000-0001-9387-2286 AD - Department of Biochemistry and Biotechnology, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Adu-Owusu, Dorcas AU - Adu-Owusu D AUID- ORCID: 0009-0000-7594-3626 AD - Department of Biochemistry and Biotechnology, College of Science, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Boateng, Josephine Ampomah AU - Boateng JA AUID- ORCID: 0009-0004-3522-5012 AD - Department of Optometry and Visual Science, College of Science, PMB, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. FAU - Boateng, Charllote AU - Boateng C AUID- ORCID: 0009-0009-3778-1318 AD - Division of Epidemiology, Biostatistics, and Environmental Health, School of Public Health, The University of Memphis, Memphis, TN 38152, United States of America. FAU - Akuffo, Kwadwo Owusu AU - Akuffo KO AD - Department of Optometry and Visual Science, College of Science, PMB, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. LA - eng GR - N.A.S.A./ PT - Journal Article PL - United States TA - Arch Clin Neuropsychol JT - Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists JID - 9004255 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - *Neuropsychological Tests MH - Cross-Sectional Studies MH - *Psychomotor Performance/physiology MH - *Executive Function/physiology MH - *Attention/physiology MH - Ghana MH - Processing Speed MH - *Cognition/physiology MH - Memory/physiology MH - *Nutritional Status/physiology MH - *Visual Perception/physiology MH - Reaction Time/physiology OTO - NOTNLM OT - attention OT - cognitive enhancements OT - executive functions OT - gender effects OT - learning and memory OT - perception/spatial processing EDAT- 2026/09/14 17:40 MHDA- 2026/09/14 17:41 CRDT- 2026/09/14 11:33 PHST- 2026/03/30 00:00 [received] PHST- 2026/08/08 00:00 [revised] PHST- 2026/08/14 00:00 [accepted] PHST- 2026/09/14 17:41 [medline] PHST- 2026/09/14 17:40 [pubmed] PHST- 2026/09/14 11:33 [entrez] AID - 8793661 [pii] AID - 10.1093/arclin/acag071 [doi] PST - ppublish SO - Arch Clin Neuropsychol. 2026 Sep 9;41(7):acag071. doi: 10.1093/arclin/acag071. PMID- 42734311 OWN - NLM STAT- MEDLINE DCOM- 20260914 LR - 20260914 IS - 1970-7096 (Electronic) IS - 1827-1987 (Linking) VI - 21 IP - 2 DP - 2026 Jul 23 TI - Household-level spatial modelling of child height-for-age in Northern Province, Rwanda: comparison of geographically weighted and neural network weighted regression models. LID - 10.4081/gh.2026.1491 [doi] AB - Childhood stunting remains a major public health concern in low- and middle-income countries, with persistent sub-national disparities. This study examined spatially varying associations between Height-for-Age z-scores (HAZ) and selected child, maternal, and household factors, and compared Geographically Weighted Regression (GWR), Multi-scale GWR (MGWR) and Geographically Neural Network Weighted Regression (GNNWR) in their ability to capture spatial heterogeneity and non-linearity. We analysed data from a cross-sectional survey conducted in December 2021 in the Northern Province of Rwanda. The survey covered 615 households, with analyses performed for 601 children aged 1-36 months. After imputation, multicollinearity screening, and feature selection, HAZ was modelled using Ordinary Least Squares (OLS), GWR, MGWR and GNNWR. Model performance was assessed using coefficient of determination (R2), Root Mean Square Error (RMSE), Akaike Information Criterion/AIC Corrected (AIC/AICc), and Moran's I of residuals. Overall stunting prevalence was 27.1%. Spatially varying associations were observed for child age, sex, birthweight, underweight status, selected childcare practices, maternal support, and household living conditions. GNNWR achieved the best training performance (R2 = 0.66; RMSE=0.74) followed by MGWR (R2 =0.51; RMSE=0.88) and GWR (R2 =0.43; RMSE=0.95). Validation performance declined for all models, although GNNWR retained a higher validation (R2=0.28) with negligible residual spatial autocorrelation (Moran's I = -0.005). GNNWR provided the strongest overall fit among the compared models and highlighted local spatial variation in associations with HAZ. However, the modest validation performance indicates that the findings should be interpreted cautiously. The workflow offers a portable framework for analysing DHS-like geocoded household datasets, but broader applicability should be assessed using spatial cross-validation, and sensitivity analyses. FAU - Kagoyire, Clarisse AU - Kagoyire C AD - Department of Earth and Environmental Sciences, Lund University, Lund, Sweden; Centre for GIS and Remote Sensing, College of Science and Technology, University of Rwanda, Kigali. FAU - Nduwayezu, Gilbert AU - Nduwayezu G AD - Department of Earth and Environmental Sciences, Lund University, Lund, Sweden; Department of Civil, Environmental and Geomatics Engineering, College of Science and Technology, University of Rwanda, Kigali. FAU - Oucheikh, Rachid AU - Oucheikh R AD - Department of Earth and Environmental Sciences, Lund University, Lund. FAU - Bizimana, Jean Pierre AU - Bizimana JP AD - Department of Spatial Planning, School of Architecture and Built Environment, College of Science and Technology, University of Rwanda, Kigali. FAU - Pilesjo, Petter AU - Pilesjo P AD - Lund University, Lund, Sweden. FAU - Mansourian, Ali AU - Mansourian A AD - Department of Earth and Environmental Sciences, Lund University, Lund. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260914 PL - Italy TA - Geospat Health JT - Geospatial health JID - 101302943 SB - IM MH - Humans MH - Rwanda/epidemiology MH - Cross-Sectional Studies MH - Female MH - Infant MH - Male MH - *Body Height MH - Child, Preschool MH - *Growth Disorders/epidemiology MH - *Family Characteristics MH - *Neural Networks, Computer MH - *Spatial Analysis MH - *Spatial Regression OTO - NOTNLM OT - Child height-for-age OT - Rwanda OT - childhood stunting OT - geographically weighted regression OT - spatial heterogeneity EDAT- 2026/09/14 11:40 MHDA- 2026/09/14 11:41 CRDT- 2026/09/14 08:42 PHST- 2026/01/28 00:00 [received] PHST- 2026/03/29 00:00 [accepted] PHST- 2026/09/14 11:41 [medline] PHST- 2026/09/14 11:40 [pubmed] PHST- 2026/09/14 08:42 [entrez] AID - 10.4081/gh.2026.1491 [doi] PST - ppublish SO - Geospat Health. 2026 Jul 23;21(2). doi: 10.4081/gh.2026.1491. Epub 2026 Sep 14. PMID- 42732250 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260913 LR - 20260914 IS - 2048-7177 (Print) IS - 2048-7177 (Electronic) IS - 2048-7177 (Linking) VI - 14 IP - 9 DP - 2026 Sep TI - Herbal Extracts and Plant-Derived Bioactives in Atopic Dermatitis: Evidence, Mechanisms, Pediatric Safety, and Translational Priorities. PG - e72239 LID - 10.1002/fsn3.72239 [doi] LID - e72239 AB - Atopic dermatitis (AD) is a chronic, relapsing epithelial and neuroimmune disease in which barrier failure, type 2 inflammation, microbial dysbiosis, itching, metabolism, and environmental exposures reinforce one another. This review critically synthesizes clinical and preclinical evidence for herbal medicines, standardized extracts, food-derived bioactives, functional-food candidates, nutraceutical ingredients, and natural-product delivery systems in AD, with particular attention to pediatric safety. Recurrent experimental signals include attenuation of Th2 cytokines and IgE, suppression of mast-cell and IL-31-related itch pathways, restoration of filaggrin and tight-junction proteins, and modulation of MAPK/NF-kappaB, JAK/STAT, Nrf2/HO-1, and NLRP3 signaling. However, efficacy is not inferred from pathway changes alone. Human evidence remains heterogeneous, and apparently promising agents have failed to outperform active comparators, produced neutral microbiome results, or raised barrier and sensitization concerns. We therefore integrate four issues that are often treated separately: food sources and processing-dependent chemistry; oral bioaccessibility and food-matrix effects; gut-skin signaling and its uncertain causal direction; and compatibility with standard topical agents, cyclosporine, biologics, and JAK inhibitors. The evidence supports selected botanicals as investigational adjuncts rather than as replacements for guideline-based care. Translation requires authenticated materials, quantitative chemical fingerprints, exposure-response studies, age-appropriate safety surveillance, interaction assessment, and controlled trials using validated clinical and barrier endpoints. CI - (c) 2026 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC. FAU - Zeng, Muhuang AU - Zeng M AUID- ORCID: 0009-0000-1047-3598 AD - Shantou Hospital of Traditional Chinese Medicine Shantou China. FAU - Yuan, Qianlan AU - Yuan Q AD - Sichuan Jinxin Xinan Women and Children Hospital Chengdu China. FAU - Huang, Shuojia AU - Huang S AD - Guangdong Chaozhou Health Vocational College Chaozhou China. FAU - Lu, Xiaofei AU - Lu X AD - Shenzhen Bao'an Chinese Medicine Hospital The Seventh Clinical College of Guangzhou University of Chinese Medicine Shenzhen China. LA - eng PT - Journal Article PT - Review DEP - 20260911 PL - United States TA - Food Sci Nutr JT - Food science & nutrition JID - 101605473 PMC - PMC13569883 OTO - NOTNLM OT - atopic dermatitis OT - dietary bioactives OT - drug delivery OT - functional foods OT - gut-skin axis OT - herbal medicine OT - nutraceuticals OT - pediatric safety COIS- The authors declare no conflicts of interest. EDAT- 2026/09/13 05:41 MHDA- 2026/09/13 05:42 PMCR- 2026/09/11 CRDT- 2026/09/13 04:07 PHST- 2026/06/22 00:00 [received] PHST- 2026/07/23 00:00 [revised] PHST- 2026/07/28 00:00 [accepted] PHST- 2026/09/13 05:42 [medline] PHST- 2026/09/13 05:41 [pubmed] PHST- 2026/09/13 04:07 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - FSN372239 [pii] AID - 10.1002/fsn3.72239 [doi] PST - epublish SO - Food Sci Nutr. 2026 Sep 11;14(9):e72239. doi: 10.1002/fsn3.72239. eCollection 2026 Sep. PMID- 42731058 OWN - NLM STAT- Publisher LR - 20260912 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 Sep 12 TI - Does the British Columbia Farmers' Market Nutrition Coupon Program improve the diet quality and food security of parents and children with lower incomes? Protocol for a dose-response, pragmatic randomized controlled trial. PG - 2601060261473062 LID - 10.1177/02601060261473062 [doi] AB - BackgroundThe British Columbia Farmers' Market Nutrition Coupon Program (FMNCP) provides lower-income households with coupons to purchase healthy foods at farmers' markets.AimThis pragmatic randomized controlled trial (RCT) will examine the effectiveness and cost-effectiveness of two higher subsidies for healthy food, compared to the usual FMNCP healthy food subsidy, on the diet quality (primary outcome), food insecurity, and other health-related outcomes of 276 parent-child dyads with lower incomes.MethodsIn this single-blind, three-arm, parallel-group pragmatic RCT, 276 parent-child dyads in lower-income households will be randomized to receive the usual FMNCP healthy food subsidy ($27/week) or a subsidy that is two ($54/week) or three times ($81/week) higher. Participants will receive 16 weeks of coupons that can be redeemed for up to 20 weeks. Outcomes will be assessed in one parent (18-64 years) and child (6-17 years) from each household pre-, mid-, and post-intervention. Dietary intake will be collected via two 24-h dietary recalls at each time point to calculate diet quality using the Healthy Eating Food Index-2019. Food insecurity and other health-related outcomes will be assessed using validated self-reported instruments. Mixed effects regression will assess the effects of the interventions, relative to the usual subsidy, on outcomes in parents and children. A full incremental analysis will quantify the cost-effectiveness ratios of the healthy food subsidies.SummaryThis dose-response RCT will show how the diet quality, food insecurity, and other health-related outcomes of parents and children vary according to subsidy amount.Trial registrationThe trial is registered at www.clinicaltrials.gov (NCT06992947). FAU - Olstad, Dana Lee AU - Olstad DL AUID- ORCID: 0000-0001-9787-9952 AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 FAU - Campbell, David Jt AU - Campbell DJ AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 AD - Department of Medicine, Cumming School of Medicine, University of Calgary Foothills Medical Centre-North Tower, Calgary, AB, Canada. AD - Department of Cardiac Sciences, Cumming School of Medicine, Calgary, AB, Canada. FAU - Sajobi, Tolulope T AU - Sajobi TT AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 FAU - O'Hara, Heather AU - O'Hara H AD - British Columbia Association of Farmers' Markets, Vancouver, BC, Canada. RINGGOLD: 576770 FAU - Leblanc, Peter AU - Leblanc P AD - British Columbia Association of Farmers' Markets, Vancouver, BC, Canada. RINGGOLD: 576770 FAU - McCormack, Gavin R AU - McCormack GR AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 FAU - Radin-Pereira, Leticia AU - Radin-Pereira L AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 FAU - Lee, Yun Yun AU - Lee YY AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 FAU - Aktary, Michelle L AU - Aktary ML AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 FAU - Minaker, Leia M AU - Minaker LM AD - Future Cities Institute, School of Planning, University of Waterloo, Waterloo, ON, Canada. RINGGOLD: 8430 FAU - Spackman, Eldon AU - Spackman E AD - Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. RINGGOLD: 70401 LA - eng SI - ClinicalTrials.gov/NCT06992947 PT - Journal Article DEP - 20260912 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - Randomized controlled trial OT - adults OT - children OT - diet quality OT - dose-response OT - farmers' market OT - food insecurity OT - healthy food subsidy OT - lower-income OT - parental shielding EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:50 CRDT- 2026/09/12 13:03 PHST- 2026/09/13 00:50 [medline] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/12 13:03 [entrez] AID - 10.1177/02601060261473062 [doi] PST - aheadofprint SO - Nutr Health. 2026 Sep 12:2601060261473062. doi: 10.1177/02601060261473062. PMID- 42730926 OWN - NLM STAT- Publisher LR - 20260912 IS - 1432-1998 (Electronic) IS - 0301-0449 (Linking) DP - 2026 Sep 12 TI - Musculoskeletal ultrasonography of lower extremity entheses in children and adolescents - a pilot study of normal B-mode and Doppler characteristics. LID - 10.1007/s00247-026-06784-y [doi] AB - BACKGROUND: Musculoskeletal ultrasonography is an important imaging modality in children. Features of arthritis are well defined and age-related normative data exist. Data on entheses are limited with no consensus on definition of pathology. OBJECTIVES: The aim of this pilot study was to evaluate entheseal thickness, echotexture, and presence of vascularity in healthy children and adolescents as a prerequisite for distinction from pathology. MATERIALS AND METHODS: Children and adolescents without musculoskeletal conditions underwent standardized B-mode and power Doppler ultrasonography of the dominant hip, knee, and ankle entheses. Entheseal thickness, echotexture, and vascularity were assessed, alongside demographic, puberty, and physical activity data. Statistical analysis included intraclass correlation coefficients, single regression, and t-tests. RESULTS: Seventy-nine healthy participants (mean age 10.5 years; 48% female) were included. All 782 evaluated entheses showed normal B-mode echotexture. Inter- and intraobserver reliability was high to excellent, with intraclass correlation coefficient values ranging from 0.84-0.99 and 0.91-0.99, respectively. Entheseal thickness correlated significantly with age (r = 0.65-0.90), lacking sex-specific differences at most sites. Minor power Doppler activity was detected in 1-44% of entheses within 2 mm of the insertion, increasing to 2-68% within 5 mm. Doppler signals were most frequent at proximal sartorius and knee entheses. CONCLUSION: Entheseal thickness correlates with age, but sex differences are minimal. Mild signals are common at the sartorius, quadriceps, and Achilles entheses with normal B-mode findings. Pathologic Doppler may require accompanying B-mode abnormalities. These data broaden the base for ultrasonography of pediatric entheses and facilitate differentiation of pathology from normal findings. CI - (c) 2026. The Author(s). FAU - Hansmann, Sandra AU - Hansmann S AUID- ORCID: 0000-0002-7486-3090 AD - Department of Neuropediatrics, General Pediatrics, Diabetology, Endocrinology and Social Pediatrics, University Children's Hospital Tubingen, Tubingen, Hoppe-Seyler-Str. 1, 72076 Tubingen, Germany. sandra.hansmann@klinikum.uni-tuebingen.de. FAU - Roth, Johannes AU - Roth J AD - Childrens's Hospital of Central Switzerland, University of Lucerne, Lucerne, Switzerland. LA - eng PT - Journal Article DEP - 20260912 PL - Germany TA - Pediatr Radiol JT - Pediatric radiology JID - 0365332 SB - IM OTO - NOTNLM OT - Doppler OT - Enthesis OT - Healthy children OT - Lower extremity OT - Pediatric rheumatology OT - Ultrasound COIS- Declarations. Ethics approval and consent to participate: The study was approved by the local Ethics Committee of the University of Tubingen (No. 721/2019BO1, approval June 10, 2020) and adhered to the Declaration of Helsinki. Written informed consent was obtained from all participants and their legal guardians. Conflicts of interest: None EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:50 CRDT- 2026/09/12 11:14 PHST- 2026/05/07 00:00 [received] PHST- 2026/09/02 00:00 [accepted] PHST- 2026/09/01 00:00 [revised] PHST- 2026/09/13 00:50 [medline] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/12 11:14 [entrez] AID - 10.1007/s00247-026-06784-y [pii] AID - 10.1007/s00247-026-06784-y [doi] PST - aheadofprint SO - Pediatr Radiol. 2026 Sep 12. doi: 10.1007/s00247-026-06784-y. PMID- 42730602 OWN - NLM STAT- Publisher LR - 20260921 IS - 1365-2516 (Electronic) IS - 1351-8216 (Linking) DP - 2026 Sep 12 TI - Living With Factor VII Deficiency-A Mixed Methods Study. LID - 10.1111/hae.70404 [doi] AB - BACKGROUND: Factor VII deficiency (FVIID) is a rare autosomal recessive disorder, resulting in potentially unpredictable and life-threatening bleeding. The prevalence of symptomatic patients is 1 in 300,000. Treatment is mostly given following bleeding, but those with the lowest levels may be offered prophylaxis. OBJECTIVES: We aimed to explore the real-life impact of FVIID on individuals and their families, focusing on psychosocial wellbeing and quality of life (QoL). METHODS: The study used a quantitative survey, including validated QoL tools, and qualitative one-to-one interviews to enable deeper exploration of the quantitative findings. RESULTS: One hundred people with FVIID (74 adults; 26 caregivers of children) completed the survey; 24 (18 adults; 6 caregivers) were interviewed. A significant gender-based disparity was observed: males were diagnosed at a median age of 4 years, versus 17 years in females (p < 0.001). 56% of respondents reported a mean of 1.25 bleeds per week; significantly higher in women than men (mean 1.65 vs. 0.53/week, respectively; p < 0.01). QoL scores decreased with increased bleeding measured by the self-BAT (p < 0.001). Bleeding was associated with significant social impact: missed physical activity (64%), avoidance of social engagements (53%) and lost education (50%). Interviews yielded six core themes associated with unmet need. CONCLUSION: FVIID causes significant challenges, disproportionately borne by women and compounded by gaps in management, especially treatment. Current treatments are burdensome and fail to prevent breakthrough bleeds. People with FVIID have unmet needs that require therapeutic innovation, improved diagnosis and management strategies, and data collection to improve their QoL and outcomes. CI - (c) 2026 The Author(s). Haemophilia published by John Wiley & Sons Ltd. FAU - Fletcher, Simon AU - Fletcher S AD - Haemnet Ltd, London, UK. FAU - Boyton, Matthew AU - Boyton M AD - Haemnet Ltd, London, UK. FAU - Bristow, Sam AU - Bristow S AD - Haemnet Ltd, London, UK. FAU - Khair, Kate AU - Khair K AD - Haemnet Ltd, London, UK. LA - eng GR - Hemab Therapeutics/ PT - Journal Article DEP - 20260912 PL - England TA - Haemophilia JT - Haemophilia : the official journal of the World Federation of Hemophilia JID - 9442916 SB - IM OTO - NOTNLM OT - factor VII deficiency OT - mixed methods OT - natural history OT - quality of life OT - unmet need EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:50 CRDT- 2026/09/12 08:23 PHST- 2026/08/31 00:00 [revised] PHST- 2026/05/27 00:00 [received] PHST- 2026/09/04 00:00 [accepted] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/13 00:50 [medline] PHST- 2026/09/12 08:23 [entrez] AID - 10.1111/hae.70404 [doi] PST - aheadofprint SO - Haemophilia. 2026 Sep 12. doi: 10.1111/hae.70404. PMID- 42730388 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260912 LR - 20260914 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 8 DP - 2026 Aug TI - Academic- and Family-Related Correlates of Anxiety Among College-Going Adolescents in Central India: A Cross-Sectional Study. PG - e114386 LID - 10.7759/cureus.114386 [doi] LID - e114386 AB - BACKGROUND: Anxiety is the most common mental health disorder among adolescents worldwide. In India, intense academic competition and evolving family dynamics add to this burden, yet systematic data from smaller central Indian districts are scarce. OBJECTIVE: This study aims to determine the prevalence and severity of anxiety among college-going adolescents aged 17-19 years in Ratlam district, Madhya Pradesh, and to examine its association with academic- and family-related factors. METHODS: In this cross-sectional observational study, 550 first-year students were enrolled from 10 colleges (five professional, five nonprofessional) through multistage random sampling between June 2023 and November 2024. Depression, anxiety, and stress were measured with the validated Depression Anxiety Stress Scale-21 (DASS-21). Family-related factors included family type, parental marital status, sibling count, and paternal education, while academic-related factors included college type. Associations were assessed with the chi-square test and Cramer's V, and factors independently associated with clinically significant anxiety were assessed using binary logistic regression, yielding adjusted odds ratios (AORs) with 95% confidence intervals (CIs), using R (version 4.3); p < 0.05 was considered significant. RESULTS: Clinically significant anxiety was recorded in 178 participants (32.36%) (mild: 110 (20.00%); moderate: 57 (10.36%); severe: 11 (2.00%)), making anxiety the most prevalent DASS-21 domain ahead of stress (116; 21.09%) and depression (62; 11.28%). On multivariable analysis, female sex (AOR: 2.26; 95% CI: 1.45-3.52; p < 0.001), professional-college enrolment (AOR: 1.45; 95% CI: 1.05-2.01; p = 0.024), and hostel residence (AOR: 1.68; 95% CI: 1.15-2.45; p = 0.007) were independently associated with higher odds of clinically significant anxiety, whereas joint-family structure was associated with lower odds (AOR: 0.62; 95% CI: 0.42-0.91; p = 0.015). Nuclear-family students showed the highest anxiety prevalence (113 of 301; 37.54%) compared with joint-family students (59 of 230; 25.70%). Music (226; 41.09%) and social connection (95; 17.27%) were the most frequently used coping strategies, whereas physical exercise was rarely used (8; 1.45%). CONCLUSIONS: Academic- and family-related factors were associated with anxiety among college-going adolescents. These findings support the need for campus-based mental-health screening, accessible counselling services, and promotion of healthy coping strategies, including physical activity. CI - Copyright (c) 2026, Chawla et al. FAU - Chawla, Heena AU - Chawla H AD - Community Medicine, Dr. Laxminarayan Pandey Government Medical College, Ratlam, IND. FAU - Sinha, Umesh AU - Sinha U AD - Community Medicine, Dr. Laxminarayan Pandey Government Medical College, Ratlam, IND. FAU - Agriya, Rajkumar AU - Agriya R AD - Community Medicine, Dr. Laxminarayan Pandey Government Medical College, Ratlam, IND. FAU - Ranasaria, Hitesh AU - Ranasaria H AD - Orthopedics, Virendra Kumar Sakhlecha Government Medical College, Neemuch, IND. LA - eng PT - Journal Article DEP - 20260811 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13566112 OTO - NOTNLM OT - academic factors OT - adolescent anxiety OT - college students OT - cross-sectional study OT - dass-21 OT - family factors OT - mental health COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Government Autonomous Medical College, Ratlam issued approval GMC/RATLAM/2023/IEC/Approval/09. The institutional ethics committee meeting held on 27.05.2023 and 28.05.2023 approved the research project entitled "Assessment of Mental Well-being and its correlates in college-going adolescents (17-19 years) of Ratlam District. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:51 PMCR- 2026/08/11 CRDT- 2026/09/12 08:04 PHST- 2026/08/11 00:00 [accepted] PHST- 2026/09/13 00:51 [medline] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/12 08:04 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - 10.7759/cureus.114386 [doi] PST - epublish SO - Cureus. 2026 Aug 11;18(8):e114386. doi: 10.7759/cureus.114386. eCollection 2026 Aug. PMID- 42729466 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260912 LR - 20260914 IS - 2451-8654 (Electronic) IS - 2451-8654 (Linking) VI - 53 DP - 2026 Oct TI - From Kitchen to Clinic: Study protocol for a family-centered, food-as-medicine approach using medically tailored meals and caregiver coaching in pediatric oncology care. PG - 101681 LID - 10.1016/j.conctc.2026.101681 [doi] LID - 101681 AB - BACKGROUND: Children undergoing cancer treatment are at high risk for malnutrition, poor diet quality, and early cardiometabolic risk due to treatment-related side effects, disrupted appetite, and household-level barriers to healthy eating. Caregivers play a central role in nutritional support during treatment but often experience substantial burden, time constraints, and nutrition insecurity. Food-as-medicine strategies, including medically tailored meals (MTMs), have shown promise in adult populations but remain underexplored in pediatric oncology, particularly during active treatment and within family-centered models. OBJECTIVE: The primary objective of this study is to evaluate the feasibility, acceptability, and adherence of From Kitchen to Clinic, a 12-week, family-centered food-as-medicine intervention that integrates MTM delivery with caregiver coaching for caregivers of children undergoing cancer treatment. Secondary objectives include collecting exploratory data on patient dietary intake, weight and lean body mass trajectories, treatment tolerance, household food and nutrition security, and caregiver burden and distress to inform a future definitive trial. METHODS: This prospective, single-arm feasibility study will enroll 60 caregiver-child dyads (N = 120) recruited from three outpatient pediatric oncology clinics at a large children's hospital. The 12-week intervention includes an intensive phase (weeks 1-8) with weekly MTM delivery and caregiver coaching, followed by a tapered phase (weeks 9-12) with reduced meal frequency and bi-weekly coaching. Feasibility outcomes include recruitment, retention, assessment completion, intervention adherence, and acceptability, evaluated against predefined progression criteria. Exploratory outcomes will be assessed at baseline and at 3, 6, and 12 months post-intervention using validated dietary, anthropometric, clinical, and caregiver-reported measures. TRIAL REGISTRATION: NCT07454902. CI - (c) 2026 The Authors. Published by Elsevier Inc. FAU - Milliron, Brandy-Joe AU - Milliron BJ AD - Department of Health Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. FAU - Schlechter, Haley AU - Schlechter H AD - Children's Hospital of Philadelphia, King of Prussia, PA, USA. FAU - Muir, Cass AU - Muir C AD - The Center for Childhood Cancer Research, Supportive Care in Oncology Research (SCORe) Program, Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Moss, Cynthia AU - Moss C AD - The Center for Childhood Cancer Research, Supportive Care in Oncology Research (SCORe) Program, Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Henstenburg, Jule Anne AU - Henstenburg JA AD - MANNA Institute, Metropolitan Area Neighborhood Nutrition Alliance, Philadelphia, PA, USA. FAU - Rappaport, Kylee AU - Rappaport K AD - Department of Health Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. FAU - Boakye, Faustina AU - Boakye F AD - Department of Health Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. FAU - Deutsch, Jonathan M AU - Deutsch JM AD - Department of Health Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. FAU - Jubelirer, Tracey AU - Jubelirer T AD - Department of Pediatrics, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA. AD - Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. LA - eng SI - ClinicalTrials.gov/NCT07454902 PT - Journal Article DEP - 20260829 PL - Netherlands TA - Contemp Clin Trials Commun JT - Contemporary clinical trials communications JID - 101671157 PMC - PMC13562409 OTO - NOTNLM OT - Caregiving OT - Feasibility OT - Food as medicine OT - Medically tailored meals OT - Nutrition OT - Pediatric oncology OT - Survivorship COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:51 PMCR- 2026/08/29 CRDT- 2026/09/12 06:51 PHST- 2026/03/18 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/29 00:00 [accepted] PHST- 2026/09/13 00:51 [medline] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/12 06:51 [entrez] PHST- 2026/08/29 00:00 [pmc-release] AID - S2451-8654(26)00088-8 [pii] AID - 101681 [pii] AID - 10.1016/j.conctc.2026.101681 [doi] PST - epublish SO - Contemp Clin Trials Commun. 2026 Aug 29;53:101681. doi: 10.1016/j.conctc.2026.101681. eCollection 2026 Oct. PMID- 42728946 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260912 LR - 20260914 IS - 2633-4402 (Electronic) IS - 2633-4402 (Linking) VI - 5 DP - 2025 TI - Adapt-Ed: co-designing adaptations to a whole school intervention to improve the uptake and impact of food provision in special schools - scoping research for a future trial. PG - 50 LID - 10.3310/nihropenres.13897.2 [doi] LID - 50 AB - BACKGROUND: Children and young people (CYP) with Special Educational Needs and/or Disabilities (SEND) are more likely to grow up in poverty and be entitled to free school meals than other children. However, they might not eat well at school because their needs aren't always accommodated. There is a need to understand school food provision for children with SEND and how the whole school food environment (WSFE) can be improved to address health inequalities. METHODS: We conducted scoping research and involved public and professional stakeholders in co-producing adaptations to a whole school food approach called Healthy Zones (HZ). The aim was to inform a future proposal to implement and evaluate the Adapt-ed HZ intervention in special schools. The four work packages (WP) (June to November 2024) were: WP1: establish stakeholder groups to co-produce a logic model and HZ adaptations; WP2: scoping reviews of food interventions for CYP with SEND; WP3: analysis of publicly available administrative data and online survey; WP4: ethnographic case studies of three special schools. RESULTS: Working with CYP with SEND, parents, carers and professionals in schools and policy roles, Adapt-Ed has provided a wealth of information to tailor and refine the HZ approach for special schools. It has included extensive public involvement and scoping research to inform future research. The work has led to a draft logic model and outline research plan which have been co-produced with public and professional stakeholders throughout. CONCLUSION: Through this project we have co-produced HZ adaptations and a draft logic model and learned there is a need and demand for Adapt-Ed HZ to enhance WSFEs in special schools and promote children's health and wellbeing. Subject to a feasibility study to refine the research protocol and test data collection methods, a trial is recommended to implement and evaluate the effect of Adapt-Ed HZ on the health and wellbeing of children with SEND. CI - Copyright: (c) 2026 O'Connell R et al. FAU - O'Connell, Rebecca AU - O'Connell R AUID- ORCID: 0000-0003-1515-2659 AD - University of Hertfordshire, Hatfield, England, UK. FAU - Ludlow, Amanda AU - Ludlow A AD - University of Hertfordshire, Hatfield, England, UK. FAU - Holford, Angus AU - Holford A AUID- ORCID: 0000-0003-2019-4845 AD - University of Essex, Colchester, England, UK. FAU - Hamilton, Laura AU - Hamilton L AUID- ORCID: 0000-0002-2388-3278 AD - University of Hertfordshire, Hatfield, England, UK. FAU - Brady, Louca-Mai AU - Brady LM AD - University of Hertfordshire, Hatfield, England, UK. FAU - Denyer, Lauren AU - Denyer L AUID- ORCID: 0009-0009-6423-9663 AD - University of Hertfordshire, Hatfield, England, UK. FAU - Feltham, Andy AU - Feltham A AD - University of Hertfordshire, Hatfield, England, UK. FAU - Wellsted, David AU - Wellsted D AD - University of Hertfordshire, Hatfield, England, UK. LA - eng PT - Journal Article DEP - 20260801 PL - England TA - NIHR Open Res JT - NIHR open research JID - 9918333281906676 PMC - PMC13560602 OAB - Why are we doing this project? Eating nutritious food at school can create more equality in the diets and lives of children from lower and higher income families. However, children with special educational needs and/or disabilities (SEND) might not be able to eat well at school because their needs aren't always accommodated. Schools can have an influence on children's eating habits, including education and activities outside school. Making learning about and eating nutritious food part of all aspects of the school day is known as a 'whole school approach'. This approach can increase the number of children who eat school dinners and improve their health and wellbeing. We wanted to explore how a 'whole school approach' called Healthy Zones might work in special schools. What have we done so far? We involved children and young people, their caregivers, and people who work in or for schools in our plans. This helped us to create an idea of what the approach needs to grow and have good outcomes. We reviewed past research to identify ways to measure nutritious eating for children with SEND. This helped us discover that there are not enough ways to measure nutritious eating for children with SEND. We explored existing information on free school meals and found out that children with SEND are more likely to be eligible for free school meals, but less likely to have one in some schools. We worked with three special schools in the East of England to find out how taking part in future research would work for them. This helped us identify the opportunities and practicalities of trying out a whole school approach in future research. What is next? We will use what we've learned to apply for a new project to test our Adapt-Ed Healthy Zones in special schools. OABL- eng OTO - NOTNLM OT - School food OT - children and young people OT - co-production OT - health inequalities OT - mixed methods OT - special educational needs and disabilities OT - whole school food environments COIS- Competing interests: From 2019-2026 RO'C was a voluntary trustee / Chair of Trustees, of the charity School Food Matters (SFM). SFM exists to teach children about food and to improve children's access to healthy, sustainable food during their time at school. SFM delivers the Healthy Zones programme and is a collaborator on the Application Development Award underpinning this work. EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:51 PMCR- 2026/08/01 CRDT- 2026/09/12 05:55 PHST- 2026/07/22 00:00 [accepted] PHST- 2026/09/13 00:51 [medline] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/12 05:55 [entrez] PHST- 2026/08/01 00:00 [pmc-release] AID - 10.3310/nihropenres.13897.2 [doi] PST - epublish SO - NIHR Open Res. 2026 Aug 1;5:50. doi: 10.3310/nihropenres.13897.2. eCollection 2025. PMID- 42728700 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261022 IS - 1439-4286 (Electronic) IS - 0018-5043 (Linking) VI - 58 IP - 10 DP - 2026 Oct TI - Association of Progesterone and Prolactin with Hepatic Steatosis in Premenopausal Women: A Prospective Cross-Sectional Study. PG - 413-418 LID - 10.1055/a-2949-7994 [doi] AB - This study aimed to investigate the association between hepatic steatosis and serum levels of reproductive hormones in premenopausal women, with particular focus on progesterone and prolactin. A total of 87 premenopausal women aged 18-45 years were included in this prospective study. Participants were classified by ultrasonographic steatosis status and grade. Blood samples obtained on day 3 of the menstrual cycle were used to measure follicle-stimulating hormone, luteinizing hormone, estradiol, progesterone, and prolactin levels. Women with overt metabolic and endocrine disorders were excluded. Multivariable logistic regression and receiver operating characteristic analyses were performed. Hepatic steatosis was present in 53 participants (60.9%), whereas 34 participants had no steatosis. Progesterone and prolactin levels were significantly lower in participants with hepatic steatosis than in those without steatosis (0.6 vs. 1.1 ng/mL and 7.9 vs. 11.0 ng/mL, respectively; both p<0.001). In multivariable analysis, older age (odds ratio: 1.32, 95% confidence interval: 1.12-1.56; p=0.001), higher body mass index (odds ratio: 1.57, 95% confidence interval: 1.19-2.08; p=0.002), lower progesterone levels (odds ratio: 0.75, 95% confidence interval: 0.58-0.98; p=0.037), and lower prolactin levels (odds ratio: 0.51, 95% confidence interval: 0.34-0.79; p=0.002) were independently associated with hepatic steatosis. Estradiol, follicle-stimulating hormone, and luteinizing hormone were not associated with steatosis. Receiver operating characteristic analysis showed a discriminative value for progesterone (area under the curve: 0.751) and prolactin (area under the curve: 0.790). Lower serum progesterone and prolactin levels were associated with hepatic steatosis after adjustment for age and body mass index. These findings support a possible relationship between reproductive hormonal milieu and hepatic steatosis in a selected premenopausal population, while the progesterone finding should be interpreted in the context of early follicular-phase measurement. CI - Thieme. All rights reserved. FAU - Ulusoy, Muhammed Aziz AU - Ulusoy MA AD - Ministry of Health Ankara Bilkent City Hospital, Department of Internal Medicine, Turkey, Cankaya. FAU - Comoglu, Mustafa AU - Comoglu M AUID- ORCID: 0000-0003-4977-9919 AD - Ministry of Health Ankara Bilkent City Hospital, Department of Internal Medicine, Turkey, Cankaya. FAU - Zengin, Oguzhan AU - Zengin O AD - Ministry of Health Ankara Bilkent City Hospital, Department of Internal Medicine, Turkey, Cankaya. FAU - Camli, Huseyin AU - Camli H AD - Ministry of Health Ankara Bilkent City Hospital, Department of Internal Medicine, Turkey, Cankaya. FAU - Uzdogan, Esma Andac AU - Uzdogan EA AD - Ministry of Health Ankara Bilkent City Hospital, Department of Medical Biochemistry, Ankara, Turkey, Cankaya. FAU - Kalkan, Emra Asfuroglu AU - Kalkan EA AD - Ministry of Health Ankara Bilkent City Hospital, Department of Internal Medicine, Turkey, Cankaya. FAU - Ates, Ihsan AU - Ates I AD - Ministry of Health Ankara Bilkent City Hospital, Department of Internal Medicine, Turkey, Cankaya. LA - eng PT - Journal Article DEP - 20260911 PL - Germany TA - Horm Metab Res JT - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JID - 0177722 RN - 9002-62-4 (Prolactin) RN - 4G7DS2Q64Y (Progesterone) RN - 9002-68-0 (Follicle Stimulating Hormone) SB - IM MH - Humans MH - Female MH - *Prolactin/blood MH - *Progesterone/blood MH - Adult MH - *Premenopause/blood MH - Prospective Studies MH - *Fatty Liver/blood MH - Cross-Sectional Studies MH - Middle Aged MH - Young Adult MH - Adolescent MH - Follicle Stimulating Hormone/blood MH - ROC Curve COIS- The authors declare that they have no conflict of interest. EDAT- 2026/09/13 00:50 MHDA- 2026/10/22 23:28 CRDT- 2026/09/12 05:33 PHST- 2026/10/22 23:28 [medline] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/12 05:33 [entrez] AID - 10.1055/a-2949-7994 [doi] PST - ppublish SO - Horm Metab Res. 2026 Oct;58(10):413-418. doi: 10.1055/a-2949-7994. Epub 2026 Sep 11. PMID- 42728638 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260912 LR - 20260914 IS - 1758-5996 (Print) IS - 1758-5996 (Electronic) IS - 1758-5996 (Linking) VI - 18 IP - 1 DP - 2026 Aug 4 TI - Unpacking adiposity: a narrative critical appraisal of diverse obesity definitions. LID - 10.1186/s13098-026-02261-6 [doi] LID - 201 AB - BACKGROUND: Obesity is a complex, multifaceted chronic disease that poses a major global health challenge. Traditionally, population-level screening and follow-up have relied heavily on body mass index (BMI). Although BMI provides a simple, standardized measure for epidemiological studies, it does not account for individual variations in muscle mass, fat distribution, or metabolic health. Consequently, relying solely on weight-to-height ratios-even when supplemented with waist circumference, waist-to-hip ratio, or waist-to-height ratio-limits precise individual diagnosis and comprehensive health risk assessment. Comprehensive risk stratification incorporating clinical factors beyond body weight is therefore needed to capture the heterogeneity of obesity and enable a more individualized, patient-centered approach to management. MAIN BODY: This critical narrative review evaluates the main definitions and classification systems used for obesity, including the traditional World Health Organization classification, the Edmonton Obesity Staging System (EOSS), the Lancet Commission framework, the European Association for the Study of Obesity framework, and classifications based on weight history. BMI remains valuable for population-level assessment and may also be useful at the individual level when combined with additional anthropometric measurements and sex-, age-, and ethnicity-specific cutoff values. The EOSS complements anthropometric assessment by incorporating metabolic, physical, psychological, and functional consequences, thereby supporting treatment intensity according to disease severity. The Lancet Commission definitions of preclinical and clinical obesity broaden diagnosis beyond BMI but have raised concerns regarding the absence of standardized screening tools, potential diagnostic inconsistency, and possible delays in treatment for people classified as having preclinical obesity. Such limitations may be particularly relevant for children and adolescents, in whom delayed intervention may increase long-term health risks. Weight-history classifications provide an additional perspective by incorporating maximum weight attained in life, supporting realistic treatment goals, reinforcing the chronic nature of obesity, reducing stigma, and encouraging long-term treatment adherence. CONCLUSION: No single classification adequately captures the biological and clinical heterogeneity of obesity. BMI should not be abandoned, but interpreted alongside anthropometric, metabolic, functional, psychological, and weight-history information. Integrating complementary classification systems may improve diagnostic accuracy, risk stratification, treatment prioritization, and patient-centered obesity care. CI - (c) 2026. The Author(s). FAU - Mancini, Marcio C AU - Mancini MC AD - Department of Endocrinology, Universidade de Sao Paulo, Sao Paulo, Brazil. mmancini@usp.br. FAU - Halpern, Bruno AU - Halpern B AD - Associacao Brasileira para o Estudo da Obesidade e Sindrome Metabolica, Sao Paulo, Brazil. FAU - de Melo, Maria Edna AU - de Melo ME AD - Department of Endocrinology, Universidade de Sao Paulo, Sao Paulo, Brazil. AD - Associacao Brasileira para o Estudo da Obesidade e Sindrome Metabolica, Sao Paulo, Brazil. FAU - Kramer, Caroline K AU - Kramer CK AD - University of Toronto, Sinai Centre for Diabetes at Mount Sinai Hospital, Toronto, Canada. LA - eng PT - Journal Article PT - Review DEP - 20260804 PL - England TA - Diabetol Metab Syndr JT - Diabetology & metabolic syndrome JID - 101488958 PMC - PMC13563844 OTO - NOTNLM OT - Adipose tissue dysfunction OT - Body mass index OT - Clinical obesity OT - Controlled obesity OT - Diet quality OT - Immunometabolism OT - Metabolic syndrome OT - Reduced obesity OT - Type 2 diabetes OT - Waist circumference COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: MCM has been on speakers' bureaus for Eli-Lilly, Boehringer Ingelheim, Novo Nordisk, Merck, EMS; has received support for attending meetings and/or traveling from Novo Nordisk and Eurofarma; has participated on advisory boards for Novo Nordisk, Eli-Lilly and Ache, Eli-Lilly, Merck, NC Pharma, Brace Pharma, Boehringer Ingelheim. BH has been on a speakers' bureau for Novo Nordisk, Eli-Lilly, Boehringer Ingelheim, Astra Zeneca, Merck; has received support for attending meetings and/or travel from Novo Nordisk; has participated on advisory boards for Novo Nordisk, Eli-Lilly, Merck, Currax, Abbott Nutrition. MEM has been on speakers' bureaus for EMS, Novo Nordisk, Merck; has received support for attending meetings and/or traveling from Novo Nordisk and Eurofarma; has participated on advisory boards for Brace Pharma. CKK has received investigator-initiated research grant from Boehringer Ingelheim not related to this work. EDAT- 2026/09/13 00:50 MHDA- 2026/09/13 00:51 PMCR- 2026/08/04 CRDT- 2026/09/12 05:30 PHST- 2026/06/01 00:00 [received] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/09/13 00:51 [medline] PHST- 2026/09/13 00:50 [pubmed] PHST- 2026/09/12 05:30 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - 10.1186/s13098-026-02261-6 [pii] AID - 2261 [pii] AID - 10.1186/s13098-026-02261-6 [doi] PST - epublish SO - Diabetol Metab Syndr. 2026 Aug 4;18(1):201. doi: 10.1186/s13098-026-02261-6. PMID- 42728168 OWN - NLM STAT- Publisher LR - 20260911 IS - 1878-1861 (Electronic) IS - 1878-1861 (Linking) DP - 2026 Aug 21 TI - The evaluation of a family-based multiple health behaviour intervention targeting girls: The Beyond the 80 feasibility trial. LID - S1440-2440(26)00530-X [pii] LID - 10.1016/j.jsams.2026.08.209 [doi] AB - OBJECTIVES: To examine the feasibility and acceptability of Beyond the 80 (BT80), a family-based healthy lifestyle intervention for school-aged girls. DESIGN: Single-arm mixed-methods feasibility trial. METHODS: BT80 was an 8-week intervention co-delivered with a National Rugby League Women's Premiership team. Eligible families included >/=1 parent and a daughter aged 7-11 years. Families participated in weekly in-person educational and practical sessions and completed home-based challenges. Topics included physical activity (including muscle-strengthening activity), sedentary behaviour, healthy eating, communication, emotion literacy, and sleep. A priori targets were set for recruitment (20 families), attendance (70%), retention (70%), fidelity (checklist; 80%), and enjoyment (self-report; 80%). Child engagement (active/passive engagement or interfering behaviour via direct observation), compliance (photo evidence of home-based challenges completed), and acceptability (child/parent self-report and focus groups) were also assessed. RESULTS: Recruitment (N = 12 families) and attendance (68%) targets were not met, whilst retention (92%) met the target. Intervention fidelity was high (98% education, 100% practical), as was child active/passive engagement (90% education, 96% practical). Child and parent enjoyment was high for educational (child: 82%, parent: 99%) and practical sessions (child: 87%, parent: 98%). Families completed on average 1-2 home-based challenges, and some families found photo submission burdensome. Data collection averaged 102.1 +/- 25.6 min at baseline and 69.7 +/- 17.9 min at intervention end. Parents found the time and measures acceptable. CONCLUSIONS: The preliminary findings for BT80 are promising, however, recruitment strategies, attendance, and home-based challenge engagement require refinement. Our findings may help to inform the development and refinement of similar family-based interventions. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - El Masri, Aymen AU - El Masri A AD - School of Health Sciences, Faculty of Health, Western Sydney University, Australia; Translational Health Research Institute, Western Sydney University, Australia. FAU - George, Emma S AU - George ES AD - School of Health Sciences, Faculty of Health, Western Sydney University, Australia; Translational Health Research Institute, Western Sydney University, Australia. FAU - West, Nicholas K AU - West NK AD - School of Health Sciences, Faculty of Health, Western Sydney University, Australia. FAU - Kennedy, Sarah G AU - Kennedy SG AD - School of Health Sciences, Faculty of Health, Western Sydney University, Australia; Translational Health Research Institute, Western Sydney University, Australia. FAU - Hliounakis, Holly AU - Hliounakis H AD - School of Health Sciences, Faculty of Health, Western Sydney University, Australia. FAU - Fleming, Catharine A K AU - Fleming CAK AD - School of Health Sciences, Faculty of Health, Western Sydney University, Australia; Translational Health Research Institute, Western Sydney University, Australia. FAU - Mackenzie, Erin AU - Mackenzie E AD - Translational Health Research Institute, Western Sydney University, Australia; Faculty of Social Sciences, Arts, Business, Education and Law, Western Sydney University, Australia. FAU - Guagliano, Justin M AU - Guagliano JM AD - School of Health Sciences, Faculty of Health, Western Sydney University, Australia; Translational Health Research Institute, Western Sydney University, Australia. Electronic address: j.guagliano@westernsydney.edu.au. LA - eng PT - Journal Article DEP - 20260821 PL - Australia TA - J Sci Med Sport JT - Journal of science and medicine in sport JID - 9812598 SB - IM OTO - NOTNLM OT - Family functioning OT - Healthy eating OT - Muscle strengthening OT - Physical activity OT - Sedentary behaviour OT - Sleep COIS- Declaration of interest statement None. EDAT- 2026/09/11 23:36 MHDA- 2026/09/11 23:36 CRDT- 2026/09/11 21:58 PHST- 2026/02/01 00:00 [received] PHST- 2026/07/20 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/09/11 23:36 [medline] PHST- 2026/09/11 23:36 [pubmed] PHST- 2026/09/11 21:58 [entrez] AID - S1440-2440(26)00530-X [pii] AID - 10.1016/j.jsams.2026.08.209 [doi] PST - aheadofprint SO - J Sci Med Sport. 2026 Aug 21:S1440-2440(26)00530-X. doi: 10.1016/j.jsams.2026.08.209. PMID- 42727707 OWN - NLM STAT- Publisher LR - 20260911 IS - 2589-5559 (Electronic) IS - 2589-5559 (Linking) DP - 2026 Sep 11 TI - Prevalence and Significance of Combined Low Muscle Volume and High Muscle Fat in Patients with Child-Pugh A-B Cirrhosis. PG - 102031 LID - S2589-5559(26)00302-2 [pii] LID - 10.1016/j.jhepr.2026.102031 [doi] AB - BACKGROUND & AIMS: Physical frailty and sarcopenia are linked to adverse outcomes and higher healthcare utilisation in liver cirrhosis. A magnetic resonance imaging (MRI) assessment combining thigh muscle volume and muscle fat infiltration identifies muscle composition (MC) phenotypes, where adverse MC (high fat, low volume) independently predicts all-cause mortality. We aimed to determine MC prevalence, correlate MRI measurements with functional and physical performance tests, and characterise MC groups in patients with liver cirrhosis undergoing hepatocellular carcinoma (HCC) surveillance. METHODS: The ACCESS-ESLD study prospectively enrolled 150 patients with liver cirrhosis. An abbreviated MRI (for HCC surveillance and an assessment of muscle quantity and body fat), blood sampling (Child-Pugh, MELD 3.0), a Short Physical Performance Battery (SPPB) test, and a Liver Frailty Index (LFI) test were performed. RESULTS: Out of 150 patients (57% males, mean age 64+/-11 years, BMI 29.3+/-5.6 kg/m(2)), 44% had alcohol-related liver disease and 28% had MASLD. Ninety per cent were Child-Pugh A, and the mean MELD was 8.9. Adverse MC was found in 21% of patients, who showed higher LFI, poorer SPPB, and 1.6 L more visceral fat. No differences in Child-Pugh, MELD, decompensation history, type 2 diabetes, or BMI were observed. Muscle measurements strongly correlated with frailty and physical tests, with muscle fat most strongly linked to the LFI and the SPPB. CONCLUSIONS: Incorporating a concise MRI protocol to assess muscle health into HCC surveillance effectively identifies one in five patients with higher frailty and poorer physical performance, independent of liver disease status. Assessing both muscle fat and volume provides additional benefit beyond muscle volume alone. IMPACT AND IMPLICATIONS: This study provides scientific justification for utilising a concise magnetic resonance imaging (MRI) protocol to assess muscle health during MR-based HCC surveillance in patients with liver cirrhosis, demonstrating its feasibility as a combined MRI-based tool for integrated diagnostics. By effectively identifying patients with adverse muscle composition, linked to higher frailty and poorer physical performance, our findings highlight a patient cohort that warrants future targeted research and the development of specific clinical strategies. The findings suggest that assessing both muscle fat and volume provides a more comprehensive understanding of muscle health than assessing muscle volume alone, potentially leading to more effective management strategies. Future longitudinal data from ACCESS-ESLD will be vital to further explore long-term outcomes and inform the clinical utility of such integrated assessments, ultimately informing refined clinical practices and patient care. CLINICAL TRIAL NUMBER: NCT05502198. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Forsgren, Mikael Fredrik AU - Forsgren MF AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; AMRA Medical AB, Linkoping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linkoping University, Linkoping, Sweden. Electronic address: mikael.f.forsgren@liu.se. FAU - Sjogren, Daniel AU - Sjogren D AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; Department of Medicine, Hoglandssjukhuset Eksjo, Region Jonkoping County Council, Eksjo, Sweden. FAU - Stjernman, Henrik AU - Stjernman H AD - Department of Internal Medicine, Ryhov Hospital Jonkoping, Region Jonkoping County Council, Jonkoping, Sweden. FAU - Nasr, Patrik AU - Nasr P AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linkoping University, Linkoping, Sweden; Clinical Department of Gastroenterology and Hepatology in Linkoping, Region Ostergotland, Linkoping, Sweden; Wallenberg Center for Molecular Medicine (WCMM), Linkoping University, Linkoping, Sweden. FAU - Balkhed, Wile AU - Balkhed W AD - Clinical Department of Gastroenterology and Hepatology in Linkoping, Region Ostergotland, Linkoping, Sweden. FAU - Cederborg, Anna AU - Cederborg A AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Goteborg, Sweden; Department of Medicine, Sahlgrenska University Hospital, Goteborg, Sweden. FAU - Holmberg, Markus AU - Holmberg M AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden. FAU - Bartholoma, Wolf AU - Bartholoma W AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linkoping University, Linkoping, Sweden; Clinical Department of Radiology in Linkoping, Region Ostergotland, Linkoping, Sweden. FAU - Jonsson, Cecilia AU - Jonsson C AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden. FAU - Lundberg, Peter AU - Lundberg P AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linkoping University, Linkoping, Sweden; Clinical Department of Radiology in Linkoping, Region Ostergotland, Linkoping, Sweden; Clinical Department of Medical Radiation Physics, Region Ostergotland, Linkoping, Sweden. FAU - Rejler, Martin AU - Rejler M AD - Futurum, Academy for Healthcare, Region Jonkoping County, Jonkoping, Sweden; The Jonkoping Academy for Improvement of Health and Welfare, Halsohogskolan, Jonkoping University, Jonkoping, Sweden. FAU - Dahlstrom, Nils AU - Dahlstrom N AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linkoping University, Linkoping, Sweden; Clinical Department of Radiology in Linkoping, Region Ostergotland, Linkoping, Sweden. FAU - Kechagias, Stergios AU - Kechagias S AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; Clinical Department of Gastroenterology and Hepatology in Linkoping, Region Ostergotland, Linkoping, Sweden. FAU - Leinhard, Olof Dahlqvist AU - Leinhard OD AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; AMRA Medical AB, Linkoping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linkoping University, Linkoping, Sweden. FAU - Ekstedt, Mattias AU - Ekstedt M AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linkoping University, Linkoping, Sweden; Clinical Department of Gastroenterology and Hepatology in Linkoping, Region Ostergotland, Linkoping, Sweden. LA - eng SI - ClinicalTrials.gov/NCT05502198 PT - Journal Article DEP - 20260911 PL - Netherlands TA - JHEP Rep JT - JHEP reports : innovation in hepatology JID - 101761237 SB - IM OTO - NOTNLM OT - Adverse muscle composition OT - Body composition OT - Frailty OT - HCC surveillance OT - Liver cirrhosis OT - Magnetic resonance imaging OT - Muscle composition OT - Muscle fat OT - Muscle volume COIS- Declaration of Competing Interest: MF is a shareholder and employee of AMRA Medical AB. PN has served on an advisory board for Boehringer Ingelheim. AC has received lecture fees from Norgine Denmark A/S. PL is shareholder of AMRA Medical AB. ODL is an employee, shareholder, and board member of AMRA Medical AB. ME has received lecture fees from Mediplast and Novo Nordisk and has served on an advisory board for Ipsen. No other author has any competing interest. EDAT- 2026/09/11 23:36 MHDA- 2026/09/11 23:36 CRDT- 2026/09/11 19:20 PHST- 2026/02/17 00:00 [received] PHST- 2026/09/02 00:00 [revised] PHST- 2026/09/05 00:00 [accepted] PHST- 2026/09/11 23:36 [medline] PHST- 2026/09/11 23:36 [pubmed] PHST- 2026/09/11 19:20 [entrez] AID - S2589-5559(26)00302-2 [pii] AID - 10.1016/j.jhepr.2026.102031 [doi] PST - aheadofprint SO - JHEP Rep. 2026 Sep 11:102031. doi: 10.1016/j.jhepr.2026.102031. PMID- 42727054 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260929 IS - 2291-5222 (Electronic) IS - 2291-5222 (Linking) VI - 14 DP - 2026 Sep 11 TI - Smartphone Apps for Preventing Adolescent Health Problems Among Health Care Professionals: Systematic Search and Quality Assessment. PG - e83908 LID - 10.2196/83908 [doi] LID - e83908 AB - BACKGROUND: Health care professionals must consider multiple dimensions of prevention when consulting with adolescents. Identifying risky behaviors early in adolescence is crucial for reducing both morbidity and mortality. General practitioners are increasingly eager to incorporate digital tools for prevention into their consultations with adolescents; however, the relevance and clinical validity of these digital tools are not always established or well-known. Consequently, primary care professionals require guidance and support in selecting relevant mobile health (mHealth) tools. OBJECTIVE: The aim of this study is to identify relevant and useful digital apps to help primary care professionals detect at-risk adolescents across all recommended areas of prevention: orthopedics, mental health, substance abuse, risk behaviors, sexual health, vaccinations, social relationships, and nutrition. METHODS: A systematic review of smartphone apps, with an analysis of content quality, was carried out by 4 researchers using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) checklist. The App Store and Google Play Store platforms were surveyed. The inclusion criteria were as follows: free of charge, date of last update, availability in French or English, relevance of the preventive approach to adolescents, and scientific validation. Four health care professionals assessed the apps: 2 selected the apps relevant to health care professionals, then 3 analyzed these apps using the French version of the Mobile App Rating Scale (MARS-F). Intraclass correlation coefficient, model (2,1) (2-way random effects, absolute agreement, single measures); standard error of measurement; and mean absolute error were also calculated. RESULTS: A total of 976 apps were identified, 49 of which had disappeared from the platforms prior to analysis. Nine apps were retained. Seven (0.72%) were included after evaluation using the MARS-F: 2 on mental health and 5 on sexual health (including 3 on contraception only). The mean MARS-F interrater score ranged from 2.5/5 to 3.8/5. The global MARS-F score demonstrated a pooled SD of 0.60 and an intraclass correlation coefficient (2,1) of 0.0003, resulting in a calculated standard error of measurement of 0.60. The average discrepancy between raters was a mean absolute error of 0.53. CONCLUSIONS: No similar studies have been identified in the literature that specifically focus on mobile apps designed to support health care professionals in delivering preventive care to adolescents. Of the 8 areas of prevention identified as relevant for adolescents, only 3 are addressed by the apps validated through our methodology (5 focus on sexual health). Consequently, current apps are insufficient to support health care professionals in their overall preventive work with adolescents. Such a review should be conducted systematically prior to the development of any new tool to prevent duplication and channel creative efforts toward truly innovative digital solutions. Furthermore, a thorough analysis of relevant, recommended websites is essential, as these resources complement the use of mobile apps designed for health care professionals. CI - (c) Elodie Million, Marijn Kuijper, Carole Bautista, Lola Pirat, Bruno Falissard, Beatrice Lognos, Francois Carbonnel. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org). FAU - Million, Elodie AU - Million E AUID- ORCID: 0000-0001-5693-6594 AD - Department of General Practice, University of Montpellier, Campus Arnaud de Villeneuve, 641 Av. du Doyen Gaston Giraud, Montpellier, 34090, France, +33(0)662865261. AD - Desbrest Institute of Epidemiology and Public Health (IDESP), UMR UA11 INSERM, University of Montpellier, Montpellier, France. FAU - Kuijper, Marijn AU - Kuijper M AUID- ORCID: 0009-0000-6223-3510 AD - Department of General Practice, University of Montpellier, Campus Arnaud de Villeneuve, 641 Av. du Doyen Gaston Giraud, Montpellier, 34090, France, +33(0)662865261. FAU - Bautista, Carole AU - Bautista C AUID- ORCID: 0009-0006-4712-7529 AD - Department of General Practice, University of Montpellier, Campus Arnaud de Villeneuve, 641 Av. du Doyen Gaston Giraud, Montpellier, 34090, France, +33(0)662865261. FAU - Pirat, Lola AU - Pirat L AUID- ORCID: 0009-0006-2249-0874 AD - Department of General Practice, University of Montpellier, Campus Arnaud de Villeneuve, 641 Av. du Doyen Gaston Giraud, Montpellier, 34090, France, +33(0)662865261. FAU - Falissard, Bruno AU - Falissard B AUID- ORCID: 0000-0002-2418-4954 AD - CESP (Centre for Research in Epidemiology and Population Health, INSERM), University Paris Sarclay, Paris, France. FAU - Lognos, Beatrice AU - Lognos B AUID- ORCID: 0000-0002-1032-3167 AD - Department of General Practice, University of Montpellier, Campus Arnaud de Villeneuve, 641 Av. du Doyen Gaston Giraud, Montpellier, 34090, France, +33(0)662865261. AD - Desbrest Institute of Epidemiology and Public Health (IDESP), UMR UA11 INSERM, University of Montpellier, Montpellier, France. FAU - Carbonnel, Francois AU - Carbonnel F AUID- ORCID: 0000-0002-8470-4798 AD - Department of General Practice, University of Montpellier, Campus Arnaud de Villeneuve, 641 Av. du Doyen Gaston Giraud, Montpellier, 34090, France, +33(0)662865261. AD - Desbrest Institute of Epidemiology and Public Health (IDESP), UMR UA11 INSERM, University of Montpellier, Montpellier, France. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260911 PL - Canada TA - JMIR Mhealth Uhealth JT - JMIR mHealth and uHealth JID - 101624439 SB - IM MH - Adolescent MH - Humans MH - *Adolescent Health/standards/trends MH - Digital Health MH - *Health Personnel/psychology/statistics & numerical data MH - *Mobile Applications/standards/statistics & numerical data/trends MH - Quality Assurance, Health Care/methods MH - Smartphone/instrumentation PMC - PMC13568167 OTO - NOTNLM OT - adolescent OT - mental health OT - mobile apps OT - preventive medicine OT - primary care OT - sexual health COIS- Conflicts of Interest: None declared. EDAT- 2026/09/11 17:36 MHDA- 2026/09/11 17:37 PMCR- 2026/09/11 CRDT- 2026/09/11 16:13 PHST- 2025/09/10 00:00 [received] PHST- 2026/06/27 00:00 [revised] PHST- 2026/07/17 00:00 [accepted] PHST- 2026/09/11 17:37 [medline] PHST- 2026/09/11 17:36 [pubmed] PHST- 2026/09/11 16:13 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - v14i1e83908 [pii] AID - 83908 [pii] AID - 10.2196/83908 [doi] PST - epublish SO - JMIR Mhealth Uhealth. 2026 Sep 11;14:e83908. doi: 10.2196/83908. PMID- 42726424 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260914 IS - 2196-1042 (Electronic) IS - 1723-7785 (Print) IS - 1723-7785 (Linking) VI - 27 IP - 1 DP - 2026 Sep 11 TI - Digital analysis of age-related dentoalveolar changes: a 50-year longitudinal study. LID - 10.1186/s40510-026-00643-0 [doi] LID - 41 AB - BACKGROUND: With the growing demand for orthodontic treatment among adults, a clear understanding of the age-related dentoalveolar changes has become increasingly important for accurate diagnosis, treatment planning, and long-term retention strategies. This study aims to characterize dentoalveolar changes in individuals with normal occlusion from early adolescence (13 years) to late adulthood (62 years) across four time points, using digitally derived measurements and strict inclusion and exclusion criteria. METHODOLOGY: Thirty orthodontically untreated subjects (11 males, 19 females) recruited through the Public Dental Health Care system in, were examined at mean ages of 13 (T1), 16 (T2), 31 (T3), and 62 years (T4). Stone casts of the maxillary and mandibular arches were digitized using a high-resolution 3D scanner. Eleven variables were digitally assessed: overjet, overbite, intercanine width, intermolar width, arch depth, palatal height, curve of Spee, clinical crown height, arch length, space deficiency, and irregularity index. Changes across time points were analyzed using the Wilcoxon signed-rank test. RESULTS: Sagittally, overjet remained stable, whereas arch depth decreased significantly in both arches. Vertically, overbite decreased significantly, while clinical crown height increased significantly in both arches. Palatal height increased significantly up to age 31, and the curve of Spee decreased significantly by age 16. Transversely, maxillary and mandibular intermolar widths, as well as maxillary intercanine width, showed no significant changes, whereas mandibular intercanine width decreased significantly. In terms of space, maxillary and mandibular arch lengths decreased significantly at all time points, accompanied by significant increases in space deficiency and in the irregularity of the mandibular incisors throughout the observation period. CONCLUSIONS: Age-related dentoalveolar changes continue from adolescence into late adulthood, supporting the concept that occlusion remains dynamic throughout life. These longitudinal findings provide clinically relevant reference data for orthodontic diagnosis, treatment planning, and the development of effective long-term retention strategies. CI - (c) 2026. The Author(s). FAU - Basim, Anas AU - Basim A AD - Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, United Arab Emirates. FAU - Naoumova, Julia AU - Naoumova J AD - Department of Orthodontics, Institute of Odontology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Public Dental Service, University Clinic of Orthodontics, Region Vastra Gotaland, Gothenburg, Sweden. FAU - Leffler, Klara AU - Leffler K AD - Department of Mathematical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Johansson, Kristina AU - Johansson K AD - Orthodontics, Department of Odontology, Faculty of Medicine, Umea University, Umea, Sweden. FAU - Persson, Maurits AU - Persson M AD - Orthodontics, Department of Odontology, Faculty of Medicine, Umea University, Umea, Sweden. FAU - Al-Taai, Nameer AU - Al-Taai N AD - Hamdan Bin Mohammed College of Dental Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, United Arab Emirates. nameer.altaai@dubaihealth.ae. AD - Orthodontics, Department of Odontology, Faculty of Medicine, Umea University, Umea, Sweden. nameer.altaai@dubaihealth.ae. LA - eng PT - Journal Article DEP - 20260911 PL - Germany TA - Prog Orthod JT - Progress in orthodontics JID - 100936353 SB - IM MH - Humans MH - Female MH - Longitudinal Studies MH - *Dental Arch/anatomy & histology/growth & development MH - Adolescent MH - Maxilla/anatomy & histology/growth & development MH - Mandible/anatomy & histology/growth & development MH - Middle Aged MH - Overbite/pathology MH - Male MH - Imaging, Three-Dimensional/methods MH - Age Factors MH - Incisor/anatomy & histology MH - Models, Dental MH - Young Adult MH - Cephalometry/methods MH - Tooth Crown/anatomy & histology MH - *Aging MH - Cuspid/anatomy & histology MH - *Alveolar Process/anatomy & histology/growth & development MH - Image Processing, Computer-Assisted/methods MH - Adult PMC - PMC13569759 OTO - NOTNLM OT - Age-related changes OT - Incisor crowding OT - Intercanine width OT - Intraclass correlation coefficient COIS- Declarations. Ethics approval: Ethical approval for this study was obtained from the Regional Ethical Board at Umea University, Sweden (registration no. 2012-410 - 31 M). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Co-author Julia Naoumova is an Associate Editor for Progress in Orthodontics and was not involved in the editorial evaluation or peer-review process of this manuscript. EDAT- 2026/09/11 17:36 MHDA- 2026/09/11 17:37 PMCR- 2026/09/11 CRDT- 2026/09/11 13:10 PHST- 2026/03/27 00:00 [received] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/11 17:37 [medline] PHST- 2026/09/11 17:36 [pubmed] PHST- 2026/09/11 13:10 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - 10.1186/s40510-026-00643-0 [pii] AID - 643 [pii] AID - 10.1186/s40510-026-00643-0 [doi] PST - epublish SO - Prog Orthod. 2026 Sep 11;27(1):41. doi: 10.1186/s40510-026-00643-0. PMID- 42726140 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20261013 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 10 DP - 2026 Sep 11 TI - Clinical and immunological predictors of baked egg tolerance in children with IgE-mediated hen's egg allergy: a cross-sectional diagnostic accuracy study. LID - 742 [pii] LID - 10.1007/s00431-026-07398-0 [doi] AB - Baked egg (BE) introduction in IgE-mediated hen's egg allergy (HEA) is a practical strategy for dietary diversification and may promote future tolerance to hen's egg. This study aims to characterise clinical and immunological profile of children with HEA undergoing BE oral food challenge (BE-OFC) and to evaluate the individual and combined predictive performance of serum-specific IgE (sIgE), skin prick test (SPT), and basophil activation test (BAT) for BE tolerance. This is a cross-sectional diagnostic accuracy study of children aged 12 months to less than 6 years with confirmed IgE-mediated HEA attending a tertiary referral centre in Barcelona. All participants underwent standardised open BE-OFC. Receiver operating characteristic (ROC) analysis was used to evaluate biomarker performance. Exploratory associations with BE tolerance were examined using Firth's penalised logistic regression. Fifty-one children completed BE-OFC; 56.9% were tolerant. Tolerance was lower in those with prior anaphylaxis (35.7% vs 64.9%), without statistical significance (p = 0.111). During BE-OFC, epinephrine was required in only two of 22 non-tolerant patients. Ovomucoid (OVM)-sIgE was the best-performing single biomarker (AUC 0.71; 95% CI 0.55-0.87; cutoff 4.48 kUA/L; sensitivity 68.2%; specificity 79.3%). Tolerant patients demonstrated lower BAT net stimulation responses across egg white concentrations. Neither SPT nor BAT markers achieved meaningful discrimination. In adjusted analyses, OVM-sIgE retained a significant independent association with BE tolerance (OR 6.2; 95% CI 1.9-22.8), while the effect of age was attenuated to non-significance. Conclusion: OVM-sIgE was the strongest predictor of BE tolerance in young children with IgE-mediated HEA. Supervised OFC appears safe even in children with prior anaphylaxis. Findings are exploratory and require prospective multicentre validation. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Machinena-Spera, Adrianna AU - Machinena-Spera A AD - Study Group for Allergic Diseases in Childhood and Adolescence, Institut de Recerca Sant Joan de Deu (IRSJD), Barcelona, Spain. adrianna.machinena@sjd.es. AD - Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain. adrianna.machinena@sjd.es. AD - Department of Surgery and Surgical Specializations, Facultat de Medicina I Ciencies de La Salut, Universitat de Barcelona, Barcelona, Spain. adrianna.machinena@sjd.es. FAU - Lozano-Blasco, Jaime AU - Lozano-Blasco J AD - Study Group for Allergic Diseases in Childhood and Adolescence, Institut de Recerca Sant Joan de Deu (IRSJD), Barcelona, Spain. AD - Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain. FAU - Jimenez-Feijoo, Rosa AU - Jimenez-Feijoo R AD - Study Group for Allergic Diseases in Childhood and Adolescence, Institut de Recerca Sant Joan de Deu (IRSJD), Barcelona, Spain. AD - Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain. FAU - Dominguez, Olga AU - Dominguez O AD - Study Group for Allergic Diseases in Childhood and Adolescence, Institut de Recerca Sant Joan de Deu (IRSJD), Barcelona, Spain. AD - Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain. FAU - Poyatos, Elisabet AU - Poyatos E AD - Clinical Laboratory, Immunology Division, Hospital Sant Joan de Deu, Barcelona, Spain. FAU - Riggioni, Carmen AU - Riggioni C AD - Division of Immunology and Allergy, The Hospital for Sick Children and the SickKids Food Allergy and Anaphylaxis Program, Toronto, ON, Canada. AD - Department of Paediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. FAU - Del Mar Folque-Gimenez, Maria AU - Del Mar Folque-Gimenez M AD - Study Group for Allergic Diseases in Childhood and Adolescence, Institut de Recerca Sant Joan de Deu (IRSJD), Barcelona, Spain. AD - Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain. FAU - Piquer-Gibert, Monica AU - Piquer-Gibert M AD - Study Group for Allergic Diseases in Childhood and Adolescence, Institut de Recerca Sant Joan de Deu (IRSJD), Barcelona, Spain. AD - Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain. FAU - Salamanca-Fernandez, Guillermo AU - Salamanca-Fernandez G AD - Medical Affairs Unit, LETI Pharma, Tres Cantos, Madrid, Spain. FAU - Sandoval-Ruballos, Monica AU - Sandoval-Ruballos M AD - Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain. FAU - Bolos, Uma AU - Bolos U AD - Immunology Department, CDB, Hospital Clinic de Barcelona, Barcelona, Spain. FAU - Torradeflot, Maria AU - Torradeflot M AD - Immunology Department, CDB, Hospital Clinic de Barcelona, Barcelona, Spain. FAU - de Landazuri, Inaki Ortiz AU - de Landazuri IO AD - Immunology Department, CDB, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Institut d'Investigacio Biomedica August Pi I Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain. FAU - Alsina, Laia AU - Alsina L AD - Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain. AD - Department of Surgery and Surgical Specializations, Facultat de Medicina I Ciencies de La Salut, Universitat de Barcelona, Barcelona, Spain. AD - Study Group for Immune Dysfunction Diseases in Children (GEMDIP), Institute of Recerca Sant Joan de Deu, Barcelona, Spain. FAU - Pascal, Mariona AU - Pascal M AD - Immunology Department, CDB, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Institut d'Investigacio Biomedica August Pi I Sunyer (IDIBAPS), Universitat de Barcelona, Barcelona, Spain. AD - Department of Medicine, Universitat de Barcelona, Barcelona, Spain. AD - RETICS Asma, Reacciones Adversas y Alergicas (ARADYAL) and RICORS Red De Enfermedades Inflamatorias (REI), Instituto Carlos III, Madrid, Spain. FAU - Alvaro-Lozano, Montserrat AU - Alvaro-Lozano M AD - Study Group for Allergic Diseases in Childhood and Adolescence, Institut de Recerca Sant Joan de Deu (IRSJD), Barcelona, Spain. AD - Pediatric Allergy and Clinical Immunology Department, Hospital Sant Joan de Deu, Barcelona, Spain. AD - Department of Surgery and Surgical Specializations, Facultat de Medicina I Ciencies de La Salut, Universitat de Barcelona, Barcelona, Spain. LA - eng PT - Journal Article DEP - 20260911 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 37341-29-0 (Immunoglobulin E) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Egg Hypersensitivity/immunology/diagnosis MH - Female MH - Cross-Sectional Studies MH - *Immunoglobulin E/blood/immunology MH - Child, Preschool MH - Male MH - Skin Tests MH - Infant MH - *Immune Tolerance/immunology MH - ROC Curve MH - Biomarkers/blood MH - Predictive Value of Tests MH - Basophil Degranulation Test MH - Cooking MH - Anaphylaxis/immunology OTO - NOTNLM OT - Baked egg OT - Basophil activation test OT - Hen's egg allergy OT - Oral food challenge OT - Ovomucoid-specific IgE COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Institutional Review Board of Hospital Sant Joan de Deu, Barcelona (reference number PIC-104-14). Consent to participate: Written informed consent was obtained from the parents or legal guardians of all participants prior to enrolment. Consent for publication: No individual person's data in any identifiable form is included in this manuscript. Aggregate and anonymised data are reported throughout. Consent to publish was obtained as part of the informed consent process. Competing interests: The authors declare no competing interests. EDAT- 2026/09/11 17:36 MHDA- 2026/09/11 17:37 CRDT- 2026/09/11 12:51 PHST- 2026/06/04 00:00 [received] PHST- 2026/09/02 00:00 [accepted] PHST- 2026/08/19 00:00 [revised] PHST- 2026/09/11 17:37 [medline] PHST- 2026/09/11 17:36 [pubmed] PHST- 2026/09/11 12:51 [entrez] AID - 10.1007/s00431-026-07398-0 [pii] AID - 10.1007/s00431-026-07398-0 [doi] PST - epublish SO - Eur J Pediatr. 2026 Sep 11;185(10):742. doi: 10.1007/s00431-026-07398-0. PMID- 42725535 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261016 IS - 1477-0377 (Electronic) IS - 1358-863X (Linking) VI - 31 IP - 5 DP - 2026 Oct TI - Normal endothelial peripheral arterial tonometry values in healthy children: A systematic review and meta-analysis. PG - 639-650 LID - 10.1177/1358863X261462856 [doi] AB - INTRODUCTION: Endothelial dysfunction is an early, reversible marker of cardiovascular disease that can already be detected in childhood. EndoPAT (endothelial peripheral arterial tonometry) provides a noninvasive and operator-independent assessment of endothelial function, but pediatric reference values are not established. By pooling EndoPAT-derived data from existing studies in healthy children, this meta-analysis aims to derive normative values and to evaluate the influence of age, sex, and body mass index (BMI) on endothelial function. METHODS: PubMed, Web of Science, and EMBASE were searched up to April 2026 for studies reporting EndoPAT measurements in healthy children aged 5-18 years. Data on study characteristics, participant demographics, and vascular parameters were extracted. Pooled estimates were calculated using random-effects models and meta-regression explored effects of age, sex, and BMI. The study protocol was registered in the PROSPERO database (CRD42025643846). RESULTS: From 8573 records, 54 studies including 3555 healthy children (13.5 +/- 2.5 years) were analyzed. The pooled mean reactive hyperemia index (RHI) was 1.73 (95% CI: 1.66-1.81), and meta-regressions showed that RHI increased with age and BMI, with no significant association observed with sex. CONCLUSION: This meta-analysis demonstrates that adult-derived RHI cutoffs for endothelial dysfunction are not applicable to children. Vascular function during childhood is influenced by age, pubertal stage, and BMI. Therefore, low RHI values in children likely reflect ongoing microvascular maturation rather than true endothelial dysfunction. These findings support the use of pediatric reference values for RHI and highlight the need for standardized pediatric EndoPAT protocols, as well as longitudinal studies to establish normal developmental trajectories and to identify early clinically relevant deviations. FAU - Makhout, Sanae AU - Makhout S AUID- ORCID: 0000-0002-8486-6025 AD - Laboratory of Experimental Medicine and Pediatrics and Member of the Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium. FAU - Degraeve, Julie AU - Degraeve J AD - Department of Pediatrics, Antwerp University Hospital, Edegem, Belgium. FAU - Beeldens, Jente AU - Beeldens J AUID- ORCID: 0009-0005-6315-2743 AD - Laboratory of Experimental Medicine and Pediatrics and Member of the Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium. FAU - Bouziotis, Jason AU - Bouziotis J AD - Clinical Trial Center, Clinical Research Center Antwerp, Antwerp University Hospital, University of Antwerp, Edegem, Belgium. FAU - Verhulst, Stijn AU - Verhulst S AUID- ORCID: 0000-0002-1922-9716 AD - Laboratory of Experimental Medicine and Pediatrics and Member of the Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium. AD - Department of Pediatrics, Antwerp University Hospital, Edegem, Belgium. FAU - Van Eyck, Annelies AU - Van Eyck A AUID- ORCID: 0000-0003-4722-969X AD - Laboratory of Experimental Medicine and Pediatrics and Member of the Infla-Med Centre of Excellence, University of Antwerp, Antwerp, Belgium. AD - Department of Pediatrics, Antwerp University Hospital, Edegem, Belgium. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260911 PL - England TA - Vasc Med JT - Vascular medicine (London, England) JID - 9610930 SB - IM MH - Humans MH - Child MH - Adolescent MH - Reference Values MH - *Manometry MH - Male MH - Child, Preschool MH - *Endothelium, Vascular/physiology/physiopathology MH - Female MH - Predictive Value of Tests MH - Age Factors MH - Hyperemia/physiopathology MH - Body Mass Index MH - Sex Factors OTO - NOTNLM OT - EndoPAT OT - endothelial function OT - pediatrics OT - reactive hyperemia index OT - reference values COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/09/11 17:36 MHDA- 2026/10/14 05:33 CRDT- 2026/09/11 12:23 PHST- 2026/10/14 05:33 [medline] PHST- 2026/09/11 17:36 [pubmed] PHST- 2026/09/11 12:23 [entrez] AID - 10.1177/1358863X261462856 [doi] PST - ppublish SO - Vasc Med. 2026 Oct;31(5):639-650. doi: 10.1177/1358863X261462856. Epub 2026 Sep 11. PMID- 42724880 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2392-1099 (Print) IS - 2449-8238 (Electronic) IS - 2392-1099 (Linking) VI - 12 IP - 2 DP - 2026 Jun TI - Are there any non-invasive methods to predict liver fibrosis in children infected by hepatitis C virus rather than liver biopsy? PG - 136-148 LID - 10.5114/ceh.2026.161502 [doi] AB - AIM OF THE STUDY: Since biopsy is an invasive procedure that is not suitable for routine monitoring, and hepatitis C virus (HCV) infection in children can lead to progressive liver damage, liver fibrosis, and its sequela, cirrhosis, aspartate aminotransferase (AST)-to-platelet ratio (APRI) and the fibrosis score (FIB-4) are increasingly substituting biopsy in the evaluation of liver fibrosis. APRI and FIB-4 are promising non-invasive markers for the safe and effective assessment of liver fibrosis. Thus, this study aimed to ascertain whether APRI and FIB-4 scores may be used to identify the stage of liver fibrosis among children diagnosed with HCV. MATERIAL AND METHODS: From July 2024 to August 2025, a total of 120 children diagnosed with HCV were enrolled in a retrospective study conducted at the Department of Pediatric Hepatology, Gastroenterology, and Nutrition, National Liver Institute, Menoufia University. The study population was divided into two groups: 22 patients were classified as the > F2 group, while 98 patients were assigned to the F2 group. More importantly, the > F2 group had considerably higher APRI, levels of serum albumin and FIB-4 than the 3 h/week) less time on the computer (51.0% vs. 33.0% reported <1 h/d) compared to non-sports club members (P<0.001) but there was no significant difference in mobile phone use and TV time. CONCLUSIONS: The present results show that low fiber intake is widespread among adolescents and that longer screen time and low PA are associated with a low fiber intake, which indicates a clustering of health behaviors. Accordingly, intervention strategies may target several behaviors to promote health in youth. CI - (c) AME Publishing Company. FAU - Greier, Carla AU - Greier C AD - Department of Sports Science, University of Innsbruck, Innsbruck, Austria. FAU - Drenowatz, Clemens AU - Drenowatz C AUID- ORCID: 0000-0002-3861-5364 AD - Division of Sport, Physical Activity and Health, University of Education Upper Austria, Linz, Austria. FAU - Dudas, Jozsef AU - Dudas J AD - Department of Otorhinolaryngology, Head and Neck Surgery, Medical University of Innsbruck, Innsbruck, Austria. FAU - Ruedl, Gerhard AU - Ruedl G AD - Department of Sports Science, University of Innsbruck, Innsbruck, Austria. FAU - Posch, Markus AU - Posch M AD - Division of Physical Education, Private University of Education (KPH-ES), Stams, Austria. FAU - Greier, Klaus AU - Greier K AD - Department of Sports Science, University of Innsbruck, Innsbruck, Austria. LA - eng PT - Journal Article DEP - 20260827 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13559115 OTO - NOTNLM OT - Diet OT - computer time OT - media use OT - sports OT - television time (TV time) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0432/coif). C.D. serves as an unpaid editorial board member of Translational Pediatrics from May 2026 to December 2027. The other authors have no conflicts of interest to declare. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/31 CRDT- 2026/09/11 09:35 PHST- 2026/05/04 00:00 [received] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 09:35 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - tp-15-08-299 [pii] AID - 10.21037/tp-2026-0432 [doi] PST - ppublish SO - Transl Pediatr. 2026 Aug 31;15(8):299. doi: 10.21037/tp-2026-0432. Epub 2026 Aug 27. PMID- 42724397 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 8 DP - 2026 Aug 31 TI - Clinical factors associated with extrapulmonary complications in children with macrolide-resistant Mycoplasma pneumoniae pneumonia: a single-center retrospective matched case-control study. PG - 309 LID - 10.21037/tp-2026-0451 [doi] LID - 309 AB - BACKGROUND: Extrapulmonary complications contribute substantially to the clinical burden of macrolide-resistant Mycoplasma pneumoniae pneumonia (R-MPP), but factors associated with these events and their combined discriminatory value remain insufficiently characterized. This study examined clinical, laboratory, radiographic, and treatment-related factors associated with extrapulmonary complications and developed a simplified classification model. METHODS: This single-center retrospective matched case-control study included children aged 3-14 years hospitalized between January 2021 and June 2024. Among 684 potentially eligible children identified from electronic medical record and microbiology databases, 448 met the criteria for genotypically confirmed R-MPP. All 52 children who developed extrapulmonary complications during the index hospitalization were included as cases. From 396 children without complications, 156 controls were individually matched at a 1:3 ratio by sex, age within 6 months, and admission date within 30 days. Candidate variables included peak inflammatory biomarkers, nadir platelet count, respiratory and computed tomography (CT) severity, and intervals from symptom onset to medical consultation and macrolide initiation. Complete-case conditional logistic regression stratified by matched set was the primary analysis; least absolute shrinkage and selection operator (LASSO) was used for variable selection, and multiple imputation was performed as a sensitivity analysis. RESULTS: Cases and controls were comparable in age, sex, admission period, nutritional status, residence, vaccination status, household tobacco exposure, and wheezing history. C-reactive protein (CRP) >100 mg/L [matched odds ratio (OR) =3.28; 95% confidence interval (CI): 1.70-6.34], lactate dehydrogenase (LDH) >400 U/L (OR =2.97; 95% CI: 1.56-5.65), macrolide initiation delay >7 days (OR =4.18; 95% CI: 2.16-8.08), and severe CT changes (OR =2.15; 95% CI: 1.08-4.29) were independently associated with complications. A three-variable model incorporating CRP, LDH, and macrolide delay achieved an optimism-corrected area under the receiver operating characteristic (ROC) curve (AUC) of 0.917, with 86.5% sensitivity and 88.5% specificity. A preliminary internal temporal assessment in 44 patients yielded an AUC of 0.892. CONCLUSIONS: Elevated CRP, elevated LDH, delayed macrolide initiation, and severe CT changes were associated with extrapulmonary complications in hospitalized children with R-MPP. The simplified model may support clinical classification, but the retrospective design, concurrent biomarker measurement, and limited temporal sample preclude causal interpretation or immediate implementation. Larger multicenter studies are required for formal validation. CI - (c) AME Publishing Company. FAU - Xu, Tianfu AU - Xu T AD - Department of Pediatrics, The Affiliated Hospital (Group) of Putian University, Putian, China. FAU - Yan, Seyan AU - Yan S AD - Department of Pediatrics, The Affiliated Hospital (Group) of Putian University, Putian, China. FAU - Huang, Saiping AU - Huang S AD - Department of Pediatrics, The Affiliated Hospital (Group) of Putian University, Putian, China. LA - eng PT - Journal Article DEP - 20260730 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13559145 OTO - NOTNLM OT - Macrolide-resistant Mycoplasma pneumoniae pneumonia (R-MPP) OT - classification model OT - extrapulmonary complications OT - pediatric pneumonia OT - treatment delay COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0451/coif). The authors have no conflicts of interest to declare. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/31 CRDT- 2026/09/11 09:32 PHST- 2026/05/09 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 09:32 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - tp-15-08-309 [pii] AID - 10.21037/tp-2026-0451 [doi] PST - ppublish SO - Transl Pediatr. 2026 Aug 31;15(8):309. doi: 10.21037/tp-2026-0451. Epub 2026 Jul 30. PMID- 42724392 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 8 DP - 2026 Aug 31 TI - The global landscape of pediatric hyperuricemia research: a bibliometric roadmap to mechanisms, management, and future therapeutics (1997-2024). PG - 339 LID - 10.21037/tp-2026-0255 [doi] LID - 339 AB - BACKGROUND: Pediatric hyperuricemia has emerged as a significant global health concern, intricately linked to the early pathogenesis of metabolic syndrome, cardiovascular disease, and chronic kidney disease. Despite extensive research in adults, critical gaps persist in our understanding of its unique pathophysiology, age-specific diagnostic criteria, and evidence-based management strategies in children. This study aims to provide a comprehensive, quantitative assessment of the global research landscape on pediatric hyperuricemia, identify pivotal thematic foci, and map emerging frontiers to guide future scientific inquiry and clinical translation. METHODS: We conducted a systematic bibliometric and visual analysis of all relevant articles and reviews indexed in the Web of Science Core Collection (WoS CC) from inception to December 20, 2024. Data were synthesized using VOSviewer, CiteSpace, and the Bibliometrix R package to construct collaboration networks, perform co-citation analyses, and track keyword evolution. RESULTS: Our analysis identified 189 publications, revealing a trajectory of fluctuating but overall increasing scholarly attention. China (n=47) and the United States (n=43) were the most prolific contributors, with St. Jude Children's Research Hospital and Harvard University leading institutional output. Authors Simonetta Genovesi and Marco Giussani were the most productive. Keyword co-occurrence analysis delineated three dominant research clusters: (I) core clinical management ("hyperuricemia", "allopurinol", "rasburicase"); (II) cardiometabolic comorbidities ("obesity", "hypertension", "metabolic syndrome"); and (III) epidemiological and risk factor profiling ("children", "uric acid", "prevalence"). Notably, recent years have witnessed an emergent focus on long-term sequelae, including "chronic kidney disease" and "acute kidney injury". CONCLUSIONS: Research into pediatric hyperuricemia remains nascent yet is rapidly gaining momentum. Our roadmap highlights four critical frontiers: elucidating developmental-stage-specific pathological mechanisms, establishing validated diagnostic thresholds, evaluating the long-term safety and efficacy of both pharmacological and non-pharmacological interventions, and defining strategies for lifelong management to mitigate adult-onset complications. We advocate for enhanced international and interdisciplinary collaboration as the cornerstone for accelerating progress in this vital field. CI - (c) AME Publishing Company. FAU - Xiao, Liang AU - Xiao L AD - Department of Pediatrics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China. FAU - Lu, Wei AU - Lu W AD - Department of Pediatrics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China. FAU - Wang, Junli AU - Wang J AD - Department of Pediatrics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China. FAU - Yu, Shengyou AU - Yu S AD - Department of Pediatrics, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, China. LA - eng PT - Journal Article DEP - 20260629 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13559144 OTO - NOTNLM OT - Pediatric hyperuricemia OT - bibliometric analysis OT - metabolic syndrome OT - therapeutic innovation OT - uric acid metabolism COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0255/coif). The authors have no conflicts of interest to declare. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/31 CRDT- 2026/09/11 09:32 PHST- 2026/03/13 00:00 [received] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 09:32 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - tp-15-08-339 [pii] AID - 10.21037/tp-2026-0255 [doi] PST - ppublish SO - Transl Pediatr. 2026 Aug 31;15(8):339. doi: 10.21037/tp-2026-0255. Epub 2026 Jun 29. PMID- 42724349 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 8 DP - 2026 Aug 31 TI - Whole-exome sequencing-centered genetic evaluation for early-onset obesity in Chinese children: a retrospective single-center cohort. PG - 330 LID - 10.21037/tp-2026-0407 [doi] LID - 330 AB - BACKGROUND: Genetic causes of early-onset obesity remain undercharacterized in East Asian children. This study evaluated a whole-exome sequencing (WES)-centered diagnostic workflow in Chinese children with obesity onset before 5 years. METHODS: Consecutive children with body mass index above the 95th percentile and obesity onset before 5 years who completed structured inpatient assessment at a single center between February 2022 and December 2023 were retrospectively analyzed. Phenotyping included clinical, biochemical, oral glucose tolerance, cortisol rhythm, and liver assessments. Genetic testing combined WES, mitochondrial DNA analysis, multiplex ligation-dependent probe amplification (MLPA) for obesity-related imprinting loci, WES-based copy-number variant and runs-of-homozygosity analyses, and Sanger validation. Variants were interpreted according to the American College of Medical Genetics and Genomics/Association for Molecular Pathology (ACMG/AMP) criteria. RESULTS: Among 23 children, clinically relevant genetic findings were identified in 6 (26.1%): melanocortin-4 receptor (MC4R) c.831T>A (p.C277*), maternal uniparental disomy of 15q11-13, and four phenotype-correlated variants of uncertain significance in UCP3, BBS1, NCOA1, and SH2B1. The definitive/likely diagnostic yield, restricted to pathogenic or confirmed imprinting findings, was 8.7% (2/23). Findings involved leptin-MC4R signaling, BBSome function, fatty-acid oxidation, and chromosomal imprinting. Genetically positive children showed numerically higher alanine aminotransferase (ALT) and aspartate aminotransferase (AST), but differences were not statistically significant. BBS1 p.T374S was relatively enriched in East Asian reference data. CONCLUSIONS: A WES-centered integrated workflow detected heterogeneous genetic mechanisms in Chinese children with early-onset obesity, but variant of uncertain significance (VUS)-associated findings should be distinguished from confirmed diagnoses. Orthogonal methylation/MLPA and runs of homozygosity (ROH) analyses were necessary for imprinting diagnosis. Larger multicenter studies and functional validation are needed. CI - (c) AME Publishing Company. FAU - Chen, Si AU - Chen S AD - Department of Endocrinology, Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Zhang, Jing AU - Zhang J AD - Department of Endocrinology, Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Ge, Liyuan AU - Ge L AD - Department of Endocrinology, Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Li, Zhonghui AU - Li Z AD - Department of Endocrinology, Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Wang, Liuxu AU - Wang L AD - Department of Endocrinology, Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Cheng, Xinran AU - Cheng X AUID- ORCID: 0000-0001-9001-4016 AD - Department of Endocrinology, Genetics and Metabolism, Chengdu Women's and Children's Center Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. LA - eng PT - Journal Article DEP - 20260722 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13559094 OTO - NOTNLM OT - Chinese children OT - Early-onset obesity OT - genetic diagnosis OT - monogenic obesity OT - whole-exome sequencing (WES) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0407/coif). The authors have no conflicts of interest to declare. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/31 CRDT- 2026/09/11 09:28 PHST- 2026/04/23 00:00 [received] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 09:28 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - tp-15-08-330 [pii] AID - 10.21037/tp-2026-0407 [doi] PST - ppublish SO - Transl Pediatr. 2026 Aug 31;15(8):330. doi: 10.21037/tp-2026-0407. Epub 2026 Jul 22. PMID- 42724246 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 8 DP - 2026 Aug 31 TI - Predictive value of the prognostic nutritional index and aggregate index of systemic inflammation for pulmonary complications in children with influenza. PG - 343 LID - 10.21037/tp-2026-0567 [doi] LID - 343 AB - BACKGROUND: Pulmonary complications drive morbidity in pediatric influenza, but early risk stratification remains challenging. This study evaluated the predictive utility of the prognostic nutritional index (PNI) and the aggregate index of systemic inflammation (AISI)-accessible biomarkers of immune-nutritional and inflammatory status-for pulmonary complications in pediatric influenza. METHODS: This retrospective study analyzed 248 pediatric patients with influenza admitted between January 2022 and December 2024. PNI and AISI were calculated from admission laboratory data. Multivariable logistic regression and receiver operating characteristic (ROC) curves were utilized to evaluate the independent and combined predictive performance of PNI and AISI for the development of pulmonary complications. RESULTS: Pulmonary complications developed in 86 patients (34.7%). These patients exhibited significantly lower PNI and higher AISI than those without complications (both P<0.001). Furthermore, PNI correlated inversely, and AISI positively, with disease severity markers including C-reactive protein (CRP), procalcitonin, fever duration, and hospital length of stay (all P<0.001). Multivariable analysis identified prolonged fever, decreased PNI, and elevated AISI as independent predictors of pulmonary complications. The combined PNI-AISI model showed higher apparent discriminatory performance than PNI or AISI alone [the area under the receiver operating characteristic curve (AUC): 0.913, sensitivity: 87.2%, specificity: 85.2%]; however, further validation is required to confirm its generalizability. CONCLUSIONS: Decreased PNI and elevated AISI independently predict pulmonary complications and disease severity in pediatric influenza. Integrating these indices provides a highly accurate, accessible, and physiologically grounded tool for early risk stratification, optimizing clinical decision-making. CI - (c) AME Publishing Company. FAU - Wu, Yuanyuan AU - Wu Y AD - Department of Pediatrics, The First People's Hospital of Hefei, Hefei, China. FAU - Zhang, Jianjian AU - Zhang J AD - Department of Intensive Care Unit, The First People's Hospital of Hefei, Hefei, China. FAU - Ke, Xuejia AU - Ke X AD - Department of Nursing, The First People's Hospital of Hefei, Hefei City, China. FAU - Pan, Junping AU - Pan J AD - Department of Pediatrics, The First People's Hospital of Hefei, Hefei, China. FAU - Hu, Yuping AU - Hu Y AD - Department of Pediatrics, The First People's Hospital of Hefei, Hefei, China. LA - eng PT - Journal Article DEP - 20260827 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13559136 OTO - NOTNLM OT - Influenza OT - aggregate index of systemic inflammation (AISI) OT - children OT - prognostic nutritional index (PNI) OT - pulmonary complications COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0567/coif). The authors have no conflicts of interest to declare. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/31 CRDT- 2026/09/11 09:15 PHST- 2026/06/07 00:00 [received] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 09:15 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - tp-15-08-343 [pii] AID - 10.21037/tp-2026-0567 [doi] PST - ppublish SO - Transl Pediatr. 2026 Aug 31;15(8):343. doi: 10.21037/tp-2026-0567. Epub 2026 Aug 27. PMID- 42724114 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 1663-9812 (Print) IS - 1663-9812 (Electronic) IS - 1663-9812 (Linking) VI - 17 DP - 2026 TI - Therapeutic drug monitoring of zonisamide in children with epilepsy: development and validation of a precise binary prediction model. PG - 1841966 LID - 10.3389/fphar.2026.1841966 [doi] LID - 1841966 AB - OBJECTIVE: This study aimed to investigate the key factors influencing the failure to achieve steady-state trough concentrations of zonisamide in pediatric patients with epilepsy. Furthermore, we sought to construct and validate a binary machine learning prediction model for zonisamide concentration attainment to provide an objective reference for therapeutic drug monitoring in clinical practice. METHODS: A retrospective analysis was conducted on 958 pediatric patients with epilepsy who received zonisamide treatment at the Department of Neurology, Kunming Children's Hospital, from May 2022 to January 2026. Multi-dimensional feature screening was performed on the training set using spearman correlation analysis, variance inflation factor multicollinearity diagnosis, univariate analysis, lasso regression, boruta algorithm, and 500-iteration bootstrap resampling. Subsequently, 17 machine learning classification models were developed. Hyperparameter optimization was achieved through grid search combined with 10-fold cross-validation. Model performance was comprehensively evaluated in terms of discrimination, calibration, and clinical net benefit using 500-iteration bootstrap resampling. Finally, SHAPley additive exPlanations analysis and a visualized decision tree were employed to interpret the feature contribution and intrinsic decision logic of the optimal model. RESULTS: Following multi-stage screening, six core predictive variables were identified: dosage, uric acid, age, total bilirubin, vitamin D, aspartate aminotransferase, and gender. A comparative analysis of the 17 machine learning models revealed that the classification and regression tree model exhibited the best comprehensive predictive performance, demonstrating superior stability and robustness under resampling validation. The area under the curve values for the internal test set and the time-split internal validation set were 0.82 and 0.87, respectively. Calibration curves and decision curve analysis confirmed ideal calibration and a wide range of clinical net benefit. SHAPley additive exPlanations analysis and decision tree results confirmed that dosage is the primary determinant of the probability of achieving target ZNS concentrations. Sex, liver and kidney function, and nutrition-related indices collectively modulate the processes of drug absorption, metabolism, and clearance, thereby influencing the risk of failing to achieve target concentrations. CONCLUSION: The machine learning prediction model constructed using the CART algorithm can accurately and stably predict whether steady-state trough concentrations of zonisamide reach the target therapeutic range in pediatric patients with epilepsy. CI - Copyright (c) 2026 Li, Tang, Li, Zong, Li and Li. FAU - Li, Huiying AU - Li H AD - Department of Pharmacy, Kunming Children's Hospital, Kunming, China. FAU - Tang, Xiaoling AU - Tang X AD - Department of Orthopedics, Kunming First People's Hospital, Kunming, China. FAU - Li, Fashuang AU - Li F AD - Department of Pharmacy, Kunming Children's Hospital, Kunming, China. FAU - Zong, Jing AU - Zong J AD - Department of Pharmacy, Kunming Children's Hospital, Kunming, China. FAU - Li, Yunwei AU - Li Y AD - Department of Pharmacy, Kunming Children's Hospital, Kunming, China. FAU - Li, Linbo AU - Li L AD - Department of Pharmacy, Kunming Children's Hospital, Kunming, China. LA - eng PT - Journal Article DEP - 20260827 PL - Switzerland TA - Front Pharmacol JT - Frontiers in pharmacology JID - 101548923 PMC - PMC13558151 OTO - NOTNLM OT - concentration OT - individualized dosing OT - machine learning OT - pediatric epilepsy OT - zonisamide COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/27 CRDT- 2026/09/11 08:40 PHST- 2026/03/29 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 08:40 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - 1841966 [pii] AID - 10.3389/fphar.2026.1841966 [doi] PST - epublish SO - Front Pharmacol. 2026 Aug 27;17:1841966. doi: 10.3389/fphar.2026.1841966. eCollection 2026. PMID- 42724052 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Insulin resistance evaluated by estimated glucose disposal rate and its association with cardiometabolic risk factors among adolescents in Northeast China. PG - 1853266 LID - 10.3389/fnut.2026.1853266 [doi] LID - 1853266 AB - BACKGROUND: Insulin resistance (IR) is a key factor in cardiometabolic diseases, but there are few practical ways to measure it in adolescents. The insulin sensitivity's surrogate measure, the eGDR, has not been well validated in young populations. METHODS: eGDR was determined by the use of waist circumference (WC), HbA1c levels, and hypertension status in this cross-sectional study of Chinese adolescents. Restricted cubic spline models and multivariate logistic regression were utilized to estimate associations between eGDR and cardiometabolic risk factors (CMRFs), such as dyslipidemia, hyperuricemia, and high fasting plasma glucose (FPG). The eGDR's discriminative performance was compared with traditional IR indices, such as HOMA-IR, TyG, AIP, TyG-BMI, and QUIKI. RESULTS: After confounders' adjustment, each SD raise in eGDR was linked with reduced odds of dyslipidemia (OR = 0.781, 95% CI: 0.703-0.866, p < 0.001) and hyperuricemia (OR = 0.884, 95% CI: 0.800-0.977, p = 0.016). eGDR showed negative correlations with atherogenic lipid subfractions, such as LDL-C, non-HDL-C, and triglycerides (TG), but not with total cholesterol (TC) or FPG. Subgroup analyses showed that the protective effect against dyslipidemia was stronger in participants with BMI in the >/= 85th percentile, and sex-specific differences in the associations with TG and FPG. eGDR was found to be better than traditional IR indices in discriminating clustered CMRFs. Sex-specific cut-offs for IR were determined: eGDR <8.06 mg/kg/min and <8.46 mg/kg/min for males and females, respectively. CONCLUSION: eGDR is a strong, non-invasive cardiometabolic risk indicator in adolescents, especially dyslipidemia and hyperuricemia. It can offer a feasible instrument of early risk stratification in this group. CI - Copyright (c) 2026 Wang, Yao, Li and Du. FAU - Wang, Yiwen AU - Wang Y AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Yao, Hui AU - Yao H AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. FAU - Li, Ling AU - Li L AD - Department of Endocrinology, Jinghua Hospital, Shenyang, China. FAU - Du, Runyu AU - Du R AD - Department of Endocrinology, Shengjing Hospital of China Medical University, Shenyang, China. LA - eng PT - Journal Article DEP - 20260827 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13558436 OTO - NOTNLM OT - adolescents OT - cardiometabolic risk OT - estimated glucose disposal rate OT - insulin resistance OT - predictive performance COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/27 CRDT- 2026/09/11 08:18 PHST- 2026/04/11 00:00 [received] PHST- 2026/07/25 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 08:18 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - 10.3389/fnut.2026.1853266 [doi] PST - epublish SO - Front Nutr. 2026 Aug 27;13:1853266. doi: 10.3389/fnut.2026.1853266. eCollection 2026. PMID- 42723982 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - A new potential intervention strategy to promote the "body-mind-brain" health development of Chinese children and adolescents: a scoping review. PG - 1862354 LID - 10.3389/fspor.2026.1862354 [doi] LID - 1862354 AB - OBJECTIVE: This scoping review maps the extent and nature of literature on Shaolin martial arts (SMA) and examines how direct, contextual, and indirect evidence may inform hypotheses about body-mind-brain health in children and adolescents. It does not evaluate intervention effectiveness. METHODS: Following PRISMA-ScR guidance, we searched PubMed, Web of Science, CNKI, and Wanfang Data from database inception to February 2026. Eligibility was defined by the population-concept-context framework. Records were classified as direct empirical evidence, contextual SMA literature, or indirect mechanistic evidence from related practices. Classical Chinese sources were used only to describe SMA principles and cultural context, not as evidence of health outcomes. RESULTS: Twelve of the 13 included sources were contextual publications on SMA history, philosophy, education, or dissemination, and only one examined Shaolin boxing in children aged 8-10 years. The broader literature on martial arts, tai chi, qigong, meditation, and physical activity provides only indirect support for proposed physical, psychological, and cognitive mechanisms. No direct evidence currently establishes that SMA reduces anxiety or depression, improves executive function, alters brain activation, or induces neuroplasticity in children and adolescents. CONCLUSION: The current literature supports SMA as a culturally grounded candidate for future intervention development, but not as an empirically validated health intervention for children and adolescents. Feasibility studies and well-designed controlled trials with standardized SMA protocols and prespecified physical, mental-health, cognitive, and neurobiological outcomes are required before effectiveness claims can be made. CI - (c) 2026 Jin, Qi, Zhang, Yang, Shi and Chen. FAU - Jin, Long AU - Jin L AD - School of Physical Education and Sport, Henan University, Kaifeng, China. FAU - Qi, Kai AU - Qi K AD - School of Sport and Brain Health, Nanjing Sport Institute, Nanjing, China. AD - Gdansk University of Physical Education and Sport, Gdansk, Poland. FAU - Zhang, Zehao AU - Zhang Z AD - School of Physical Education and Sport, Henan University, Kaifeng, China. FAU - Yang, Jia AU - Yang J AD - School of Sport and Brain Health, Nanjing Sport Institute, Nanjing, China. AD - College of Physical Education, Yangzhou University, Yangzhou, China. FAU - Shi, Yifan AU - Shi Y AD - School of Sport and Brain Health, Nanjing Sport Institute, Nanjing, China. AD - College of Physical Education, Yangzhou University, Yangzhou, China. FAU - Chen, Aiguo AU - Chen A AD - School of Sport and Brain Health, Nanjing Sport Institute, Nanjing, China. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260827 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13558168 OTO - NOTNLM OT - Shaolin martial arts OT - adolescents OT - body OT - brain OT - children OT - health OT - intervention strategy OT - mind COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/27 CRDT- 2026/09/11 07:39 PHST- 2026/04/22 00:00 [received] PHST- 2026/08/13 00:00 [revised] PHST- 2026/08/18 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 07:39 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - 10.3389/fspor.2026.1862354 [doi] PST - epublish SO - Front Sports Act Living. 2026 Aug 27;8:1862354. doi: 10.3389/fspor.2026.1862354. eCollection 2026. PMID- 42723824 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260912 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Distinct metabolic phenotypes in adolescents with obesity identified by unsupervised learning: associations with insulin resistance and resting energy expenditure. PG - 1875870 LID - 10.3389/fendo.2026.1875870 [doi] LID - 1875870 AB - BACKGROUND: Pediatric obesity is characterized by substantial metabolic heterogeneity, including adiposity, insulin resistance, inflammation, and energy metabolism. Traditional categorical classifications may inadequately capture this complexity. Objective: To identify clinically meaningful metabolic phenotypes using unsupervised clustering and to compare the statistical performance and clinical interpretability of two- and three-cluster solutions. METHODS: In this cross-sectional study, 758 children and adolescents with obesity underwent anthropometric, biochemical, and indirect calorimetry assessments. Fat-free mass was estimated using validated bioimpedance-based equations, and fat-free mass index (FFMI) was standardized before clustering. K-means clustering (k = 2 and k = 3) was performed using FFMI z-score, BMI-SDS, HOMA-IR, triglycerides, and HDL-cholesterol. Cluster validity was assessed using the Silhouette, Elbow, Davies-Bouldin index, Calinski-Harabasz index, and Gap statistic methods. Validation employed variables not included in clustering, such as glucose-insulin dynamics, inflammatory and hepatic markers, blood pressure, respiratory quotient, and resting energy expenditure (REE). Group comparisons were performed using Kruskal-Wallis and Dunn's post-hoc tests with false discovery rate correction. RESULTS: Both clustering solutions demonstrated significant separation across metabolic domains. The two-cluster model identified metabolically favourable and unfavourable phenotypes differing in adiposity, insulin resistance, inflammatory burden, hepatic markers, blood pressure, and REE. The three-cluster solution revealed a more granular metabolic stratification with an intermediate phenotype characterized by partial metabolic impairment. Validation confirmed robust differences across physiological variables (all FDR-adjusted p < 0.05). Although the two-cluster solution showed slightly superior internal validity, the three-cluster model provided greater clinical granularity and phenotypic resolution. CONCLUSIONS: Unsupervised clustering identified biologically coherent metabolic phenotypes in pediatric obesity. While the two-cluster solution provided statistically robust stratification, the three-cluster configuration captured a broader spectrum of metabolic heterogeneity and risk profiles, supporting the application of higher-resolution phenotyping approaches in pediatric endocrinology and metabolic risk assessment. CI - Copyright (c) 2026 Sonza, Tamini, Bondesan, Caroli, Abbruzzese and Sartorio. FAU - Sonza, Anelise AU - Sonza A AD - Centro de Ciencias da Saude e do Esporte (CEFID), Department of Physical Therapy, Programa de Pos-Graduacao em Ciencias do Movimento Humano (PPGCMH), Universidade do Estado de Santa Catarina (UDESC), Florianopolis, Brazil. AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. FAU - Tamini, Sofia AU - Tamini S AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. FAU - Bondesan, Adele AU - Bondesan A AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. FAU - Caroli, Diana AU - Caroli D AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. FAU - Abbruzzese, Laura AU - Abbruzzese L AD - Division of Auxology, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. FAU - Sartorio, Alessandro AU - Sartorio A AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. AD - Division of Auxology, Istituto Auxologico Italiano, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Piancavallo-Verbania, Italy. LA - eng PT - Journal Article DEP - 20260827 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Insulin Resistance/physiology MH - Female MH - Cross-Sectional Studies MH - Adolescent MH - Phenotype MH - *Energy Metabolism/physiology MH - Male MH - *Pediatric Obesity/metabolism MH - Child MH - *Unsupervised Machine Learning MH - Clustering Algorithms MH - Cluster Analysis MH - Body Mass Index PMC - PMC13557994 OTO - NOTNLM OT - clustering analysis OT - energy metabolism OT - insulin resistance OT - metabolic phenotyping OT - obesity OT - pediatric endocrinology COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/11 11:38 MHDA- 2026/09/11 11:39 PMCR- 2026/08/27 CRDT- 2026/09/11 06:04 PHST- 2026/05/08 00:00 [received] PHST- 2026/08/04 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/09/11 11:39 [medline] PHST- 2026/09/11 11:38 [pubmed] PHST- 2026/09/11 06:04 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - 10.3389/fendo.2026.1875870 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Aug 27;17:1875870. doi: 10.3389/fendo.2026.1875870. eCollection 2026. PMID- 42723747 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260911 LR - 20260912 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Preoperative prognostic nutritional index and in-hospital mortality in neonates undergoing cardiac surgery for congenital heart disease: a single-center retrospective study. PG - 1860048 LID - 10.3389/fnut.2026.1860048 [doi] LID - 1860048 AB - BACKGROUND: Neonates undergoing cardiac surgery for congenital heart disease (CHD) represent one of the highest-risk subpopulations in pediatric cardiac surgery. Preoperative nutritional and immune reserve may substantially influence perioperative resilience, yet practical neonatal-specific nutritional risk markers remain insufficiently defined. OBJECTIVE: To evaluate the association between preoperative prognostic nutritional index (PNI) and in-hospital mortality in neonates undergoing cardiac surgery for CHD, and to explore a neonatal-specific cutoff value for early risk stratification. METHODS: This retrospective single-center cohort study included 433 neonates ( /= 20 indicating elevated susceptibility. Dietary behaviors during the previous 6 months were self-reported and categorized into index-based, macronutrient-focused, pattern/lifestyle, and special or plant-based diets. Multivariable logistic regression models and general linear models were used to examine associations between dietary variables and eating disorder susceptibility and symptom severity. RESULTS: Among the 188 participants included in the primary analysis, 90 (47.9%) participants were susceptible to eating disorders. Participants who had followed any dietary regimen in the previous 6 months were significantly more likely to exhibit eating disorder susceptibility compared with non-dieters (p < 0.001). DISCUSSION: These findings suggest that recent engagement in dieting, rather than specific dietary characteristics, is associated with increased eating disorder susceptibility among adults in Riyadh. Public health efforts should emphasize balanced, evidence-based dietary guidance and increased awareness of the potential psychological risks of unsupervised dieting. Longitudinal research is needed to clarify temporal relationships and causal pathways. CI - (c) 2026 The Author(s). Brain and Behavior published by Wiley Periodicals LLC. FAU - Aldahash, Rehab A AU - Aldahash RA AUID- ORCID: 0000-0003-2703-3585 AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alturki, Haifa Y AU - Alturki HY AUID- ORCID: 0009-0000-6048-8528 AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alonazi, Shahad G AU - Alonazi SG AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Dabbour, Joury AU - Dabbour J AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Aldossari, Shahad M AU - Aldossari SM AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Aldhfayan, Sara AU - Aldhfayan S AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. LA - eng GR - PNURSP2026R533/Princess Nourah bint Abdulrahman University Researchers Supporting Project/ GR - PNURSP2026R533/Princess Nourah Bint Abdulrahman University/ PT - Journal Article PL - United States TA - Brain Behav JT - Brain and behavior JID - 101570837 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Adult MH - *Feeding and Eating Disorders/epidemiology MH - Female MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - Adolescent MH - *Diet MH - Middle Aged MH - *Feeding Behavior/physiology MH - Disease Susceptibility PMC - PMC13563051 OTO - NOTNLM OT - Eating Attitudes Test (EAT-26) OT - Saudi Arabia OT - dietary patterns OT - dieting behavior OT - eating disorder susceptibility COIS- The authors declare no conflicts of interest. EDAT- 2026/09/11 05:36 MHDA- 2026/09/11 05:37 PMCR- 2026/09/10 CRDT- 2026/09/11 02:43 PHST- 2026/07/27 00:00 [revised] PHST- 2026/01/21 00:00 [received] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/09/11 05:37 [medline] PHST- 2026/09/11 05:36 [pubmed] PHST- 2026/09/11 02:43 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - BRB371688 [pii] AID - 10.1002/brb3.71688 [doi] PST - ppublish SO - Brain Behav. 2026 Sep;16(9):e71688. doi: 10.1002/brb3.71688. PMID- 42722762 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20261013 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 10 DP - 2026 Sep 10 TI - Association between insulin resistance and obstructive sleep apnea in non-diabetic children with obesity. LID - 739 [pii] LID - 10.1007/s00431-026-07395-3 [doi] AB - Although several studies have demonstrated an independent association between obstructive sleep apnea (OSA) and insulin resistance, the evidence remains inconsistent. We aimed to investigate the relationship between the presence and severity of OSA and insulin resistance in non-diabetic children with obesity and to explore the potential role of homeostasis model assessment-insulin resistance index (HOMA-IR) in identifying children at higher risk for OSA. Children with obesity aged 6-18 years who underwent polysomnography were retrospectively analyzed. Patients with diabetes, neuromuscular disorders, craniofacial anomalies, or those receiving treatment affecting insulin sensitivity were excluded. Age, sex, BMI, and oral glucose tolerance test (OGTT) results were extracted from medical records, and HOMA-IR was calculated. Patients were divided into two groups based on their obstructive apnea-hypopnea index (OAHI): < 2 and >/= 2 events/h. ROC analysis was performed for HOMA-IR to determine the optimal cutoff value for identifying patients with OSA. A total of 90 children with obesity were enrolled, among whom 39 (43.3%) had OSA. The groups were comparable in terms of age and sex. Median HOMA-IR values were significantly higher in the OSA group (p = 0.014). Total OAHI showed moderately positive correlation with HOMA-IR (rho = 0.325, p = 0.002), and baseline insulin levels measured during OGTT (rho = 0.323, p = 0.002). In multiple linear regression analysis, HOMA-IR remained independently associated with OSA severity after adjustment for age, sex, BMI z-score, sleep efficiency, and pubertal status (beta = 0.691, p = 0.025). ROC analysis identified a HOMA-IR cutoff of 3.39, with 72% sensitivity and 59% specificity for OSA. CONCLUSION: HOMA-IR was independently associated with OSA severity in children with obesity, suggesting that insulin resistance may serve as a useful adjunct marker for identifying patients at higher risk and prioritizing PSG evaluation. WHAT IS KNOWN: * Childhood obesity is strongly associated with both obstructive sleep apnea (OSA) and insulin resistance. Whether insulin resistance contributes to OSA risk beyond the effect of obesity remains controversial. * Access to polysomnography (PSG) is limited, creating an unmet need for practical tools to identify children at greatest risk for OSA. WHAT IS NEW: * To our knowledge, this is the first pediatric study to evaluate HOMA-IR as a tool for identifying children with obesity at increased risk of obstructive sleep apnea and to propose a clinically applicable HOMA-IR threshold for prioritizing polysomnography referral. * In non-diabetic children with obesity, insulin resistance was independently associated with OSA severity, regardless of obesity, pubertal status, and other clinically relevant confounders. Children with HOMA-IR >/= 3.39 had a substantially greater burden of obstructive sleep apnea. These findings support HOMA-IR as a simple, widely available biomarker that could help prioritize children with obesity for PSG evaluation and improve risk stratification in pediatric sleep medicine. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Sunman, Birce AU - Sunman B AD - Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey. bircesunman@gmail.com. AD - Department of Pediatric Pulmonology, School of Medicine, Hacettepe University, Ihsan Dogramaci Children's Hospital, 06230, Ankara, Turkey. bircesunman@gmail.com. FAU - Alboga, Didem AU - Alboga D AD - Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Akgul Erdal, Meltem AU - Akgul Erdal M AD - Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Demir, Havva Ipek AU - Demir HI AD - Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Senkalfa, Burcu AU - Senkalfa B AD - Department of Pediatric Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Vuralli, Dogus AU - Vuralli D AD - Department of Pediatric Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Emiralioglu, Nagehan AU - Emiralioglu N AD - Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Gonc, Nazli AU - Gonc N AD - Department of Pediatric Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Ozon, Alev AU - Ozon A AD - Department of Pediatric Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Yalcin, Ebru AU - Yalcin E AD - Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Dogru, Deniz AU - Dogru D AD - Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey. FAU - Ozcelik, Ugur AU - Ozcelik U AD - Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260910 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Sleep Apnea, Obstructive/diagnosis/complications/etiology MH - *Insulin Resistance MH - Child MH - Male MH - Female MH - Adolescent MH - Retrospective Studies MH - Polysomnography MH - *Pediatric Obesity/complications MH - Severity of Illness Index MH - Glucose Tolerance Test MH - Risk Factors MH - ROC Curve MH - Body Mass Index OTO - NOTNLM OT - AHI OT - Child OT - Insulin resistance OT - Sleep apnea COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the Ethics Committee of Hacettepe University (Approval No: GO 22/138) and conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from the parents or legal guardians of all participants, and assent was obtained from children when appropriate. Consent for publication: All authors have read and approved the final manuscript and consent to its publication. Competing interests: The authors declare no competing interests. EDAT- 2026/09/11 05:36 MHDA- 2026/09/11 05:37 CRDT- 2026/09/10 23:55 PHST- 2026/06/22 00:00 [received] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/08/17 00:00 [revised] PHST- 2026/09/11 05:37 [medline] PHST- 2026/09/11 05:36 [pubmed] PHST- 2026/09/10 23:55 [entrez] AID - 10.1007/s00431-026-07395-3 [pii] AID - 10.1007/s00431-026-07395-3 [doi] PST - epublish SO - Eur J Pediatr. 2026 Sep 10;185(10):739. doi: 10.1007/s00431-026-07395-3. PMID- 42722725 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260917 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Sep 8 TI - Probability of predicting dietary pattern adherence among primary schoolchildren based on socio-demographic data, anthropometric parameters, physical activity levels, and nutritional knowledge. LID - 10.1038/s41598-026-70753-6 [doi] LID - 28356 AB - Adolescence is a critical period of rapid physical and psychosocial development during which eating behaviours are influenced by a variety of internal and external factors. Understanding these relationships is crucial for preventing unhealthy dietary habits and for effective nutrition education. This cross-sectional study included 7,763 schoolchildren aged 10-12 (49.2% boys, 50.8% girls) from Polish schools. The validated questionnaire was used to assess children's nutritional knowledge, dietary habits, and physical activity. Standard anthropometric measurements (body weight, height, waist circumference) were taken, and BMI, WHtR, RFMp, and TMI were calculated. Descriptive statistics were used for sample characteristics. Principal component analysis (PCA) with varimax rotation (MSA = 0.796) was used to identify dietary patterns. Logistic regression modeled predictors of belonging to the highest tertile. Three dietary patterns were identified: Salty-Sweet, Plant-Dairy, and Protein. Children classified as overweight according to the RFMp index and children who were very physically active showed less adherence to the Salty-Sweet Pattern. Schoolchildren who were underweight according to the BMI index and those with low nutritional knowledge were more likely to follow the Salty-Sweet Pattern. Girls, children with an elevated waist-to-hip ratio (WHtR), and very physically active children were more likely to be in the third tertile of the Plant-Dairy Pattern. Schoolchildren with low nutritional knowledge showed less adherence to this pattern. Girls showed less adherence to the protein pattern, whereas underweight children and those who were very physically active showed greater adherence. The dietary patterns of schoolchildren are interrelated, and knowledge of nutrition and physical activity is the main modifiable determinant. These factors can be utilised when developing strategies for regularly assessing nutritional status and providing specialist advice to schoolchildrens, their families, and teachers. CI - (c) 2026. The Author(s). FAU - Drywien, Malgorzata Ewa AU - Drywien ME AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Warsaw, Poland. FAU - Czarniecka-Skubina, Ewa AU - Czarniecka-Skubina E AD - Department of Food Gastronomy and Food Hygiene, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Nowoursynowska st. 159c, Warsaw, 02-787, Poland. ewa_czarniecka-skubina@sggw.edu.pl. FAU - Hamulka, Jadwiga AU - Hamulka J AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Warsaw, Poland. FAU - Gebski, Jerzy AU - Gebski J AD - Department of Food Market and Consumer Research, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Warsaw, Poland. FAU - Januszko, Olga AU - Januszko O AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Warsaw, Poland. FAU - Sadowska, Joanna AU - Sadowska J AD - Department of Applied Microbiology and Human Nutrition Physiology, West Pomeranian University of Technology in Szczecin, Szczecin, Poland. FAU - Gutkowska, Krystyna AU - Gutkowska K AD - Department of Food Market and Consumer Research, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences SGGW, Warsaw, Poland. LA - eng GR - MEiN/2022/DPI/96 of 7 March 2022/Polish Ministry of Education and Science/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260908 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Child MH - *Exercise MH - Male MH - *Feeding Behavior MH - Anthropometry MH - Cross-Sectional Studies MH - *Health Knowledge, Attitudes, Practice MH - Body Mass Index MH - Poland MH - *Diet MH - Surveys and Questionnaires PMC - PMC13562532 OTO - NOTNLM OT - Anthropometric data OT - Dietary patterns OT - Nutritional knowledge OT - Physical activity OT - Schoolchildren OT - Socio-demographic factors COIS- Declarations. Competing interests: Ewa Czarniecka-Skubina - Editor Board Member. Implications and contribution: This study has implications for educational and public health policies targeting young people. Adolescents follow distinct dietary patterns shaped by modifiable factors. These findings may inform strategies to prevent nutritional deficiencies through regular dietary assessment and targeted guidance for schoolchildrenadolescents, families, and educators. EDAT- 2026/09/11 05:36 MHDA- 2026/09/11 05:37 PMCR- 2026/09/08 CRDT- 2026/09/10 23:46 PHST- 2026/07/03 00:00 [received] PHST- 2026/09/04 00:00 [accepted] PHST- 2026/09/11 05:37 [medline] PHST- 2026/09/11 05:36 [pubmed] PHST- 2026/09/10 23:46 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - 10.1038/s41598-026-70753-6 [pii] AID - 70753 [pii] AID - 10.1038/s41598-026-70753-6 [doi] PST - epublish SO - Sci Rep. 2026 Sep 8;16(1):28356. doi: 10.1038/s41598-026-70753-6. PMID- 42722700 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261005 IS - 2092-6413 (Electronic) IS - 1226-3613 (Print) IS - 1226-3613 (Linking) VI - 58 IP - 9 DP - 2026 Sep TI - Linking visceral fat accumulation to gut microbiota: key bacterial taxa and their roles in the glycogen synthesis pathway. PG - 3113-3126 LID - 10.1038/s12276-026-01828-7 [doi] AB - Obesity, marked by visceral fat accumulation, has a complex relationship with the gut microbiome that impacts body weight and fat accumulation. However, previous studies did not account for fat distribution, reflecting only overall fat mass, leaving specifics of this relationship partially understood. Here we analyzed the mechanistic links between visceral fat and the microbiome in a large cohort of healthy Koreans. Using permutational multivariate analysis of variance and prediction modeling, we examined associations between microbial profiles and metabolic variables including insulin, triglycerides, waist circumference and visceral fat. The strongest correlations were noted with specific enterotypes. Shotgun sequencing revealed that visceral fat is linked to the glycogen synthesis pathway influenced by Dorea longicatena and Bifidobacterium adolescentis. This suggests that these specific microbial signatures and their associated functional potential play a role in visceral fat-related obesity. To validate these findings, we conducted an in vivo study using diet-induced obesity mouse model. Oral administration of D. longicatena or B. adolescentis significantly promoted body weight gain and fat mass expansion and induced hepatic lipogenic gene upregulation. The prevalence of these strains in Korean and American populations highlights their global relevance, contributing to the development of personalized treatments and advanced health strategies. CI - (c) 2026. The Author(s). FAU - Kim, Nam-Eun AU - Kim NE AUID- ORCID: 0000-0003-4155-2584 AD - Institute of Health and Environment, Seoul National University, Seoul, Republic of Korea. AD - Department of Medical Informatics, Jeonbuk National University Medical School, Jeonju, Republic of Korea. FAU - Cho, Beomki AU - Cho B AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Kim, Yunjae AU - Kim Y AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Kim, Gihyeon AU - Kim G AD - Genomic Medicine Institute, Medical Research Center, Seoul National University, Seoul, Republic of Korea. AD - Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea. AD - Genome and Company, Gyeonggi-do, Republic of Korea. FAU - Yie, Ga-Eun AU - Yie GE AD - Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea. FAU - Kim, Haeon AU - Kim H AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Park, Jaesung AU - Park J AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Kim, Hyun AU - Kim H AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Jeong, Chanyoung AU - Jeong C AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Lee, Minji AU - Lee M AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Joo, Yanghyun AU - Joo Y AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Lim, Sua AU - Lim S AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Park, Sihyeon AU - Park S AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Hong, Yeji AU - Hong Y AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Min, Kyungchan AU - Min K AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Cho, Belong AU - Cho B AD - Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea. AD - Department of Family Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. FAU - Yun, Jae Moon AU - Yun JM AD - Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea. AD - Department of Family Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. FAU - Jung, Eun Sung AU - Jung ES AD - HEM Pharma, Gyeonggi-do, Republic of Korea. FAU - Ji, Yosep AU - Ji Y AD - HEM Pharma, Gyeonggi-do, Republic of Korea. FAU - Cho, Seongbeom AU - Cho S AD - College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University, Seoul, Republic of Korea. FAU - Seong, Je Kyung AU - Seong JK AD - Laboratory of Developmental Biology and Genomics, Research Institute for Veterinary Science, and BK21 PLUS Program for Creative Veterinary Science Research, College of Veterinary Medicine, Seoul National University, Seoul, Republic of Korea. AD - Korea Model Animal Priority Center, Seoul National University, Seoul, Republic of Korea. FAU - Park, Hansoo AU - Park H AD - Department of Biomedical Science and Engineering, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. hspark27@gist.ac.kr. AD - Genome and Company, Gyeonggi-do, Republic of Korea. hspark27@gist.ac.kr. FAU - Park, Jin-Ho AU - Park JH AD - Department of Family Medicine, Seoul National University Hospital, Seoul, Republic of Korea. pjhn@snu.ac.kr. AD - Department of Family Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. pjhn@snu.ac.kr. FAU - Won, Sungho AU - Won S AUID- ORCID: 0000-0001-5751-5089 AD - Institute of Health and Environment, Seoul National University, Seoul, Republic of Korea. won1@snu.ac.kr. AD - Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul, Republic of Korea. won1@snu.ac.kr. AD - RexSoft Corp, Seoul, Republic of Korea. won1@snu.ac.kr. AD - Department of Public Health Sciences, Seoul National University, Seoul, Republic of Korea. won1@snu.ac.kr. LA - eng GR - 2022R1A2C2008976/Ministry of Science, ICT and Future Planning (MSIP)/ GR - RS-2023-00228315/Ministry of Science, ICT and Future Planning (MSIP)/ GR - 2024-ER2108-00/Ministry of Health, Welfare and Family Affairs | Korea National Institute of Health (KNIH)/ GR - RS-2021-NR060088/National Research Foundation of Korea (NRF)/ GR - KSC-2024-CRE-0514/National Research Foundation of Korea (NRF)/ PT - Journal Article DEP - 20260910 PL - United States TA - Exp Mol Med JT - Experimental & molecular medicine JID - 9607880 RN - 9005-79-2 (Glycogen) SB - IM MH - Animals MH - *Intra-Abdominal Fat/metabolism MH - *Gastrointestinal Microbiome MH - Humans MH - Male MH - *Glycogen/biosynthesis MH - Mice MH - *Obesity/metabolism/microbiology/etiology MH - Female MH - *Bacteria/classification/genetics MH - Bifidobacterium adolescentis PMC - PMC13633279 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/09/11 05:36 MHDA- 2026/10/03 05:33 PMCR- 2026/09/10 CRDT- 2026/09/10 23:43 PHST- 2025/09/11 00:00 [received] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/05/22 00:00 [revised] PHST- 2026/10/03 05:33 [medline] PHST- 2026/09/11 05:36 [pubmed] PHST- 2026/09/10 23:43 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - 10.1038/s12276-026-01828-7 [pii] AID - 1828 [pii] AID - 10.1038/s12276-026-01828-7 [doi] PST - ppublish SO - Exp Mol Med. 2026 Sep;58(9):3113-3126. doi: 10.1038/s12276-026-01828-7. Epub 2026 Sep 10. PMID- 42721609 OWN - NLM STAT- Publisher LR - 20260910 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 153 DP - 2026 Aug 18 TI - Not only bowel: opportunistic assessment of sarcopenia in pediatric ulcerative colitis patients undergoing magnetic resonance enterography. PG - 113402 LID - S0899-9007(26)00309-6 [pii] LID - 10.1016/j.nut.2026.113402 [doi] AB - PURPOSE: Malnutrition and sarcopenia are under-recognized complications in pediatric inflammatory bowel disease, with an understudied interrelationship. This exploratory study aimed to estimate the prevalence of sarcopenia in children with newly diagnosed Ulcerative Colitis (UC) and to investigate associations between opportunistically MRE-derived muscle metrics and clinical, laboratory, and endoscopic disease activity. MATERIALS AND METHODS: Retrospective enrollment of 20 children aged 6-18 years who were ultimately diagnosed with UC and had undergone MRE as part of the systematic initial diagnostic work-up for suspected pediatric IBD. Total psoas muscle area (tPMA) was measured on axial T2-weighted images at the L3 vertebral level and used as a sarcopenia biomarker: "at risk of sarcopenia" with tPMA <10th percentile, and with "severe sarcopenia" /=0.70, 0.80, and 0.90). Sensitivity analyses using the combined durations of sessions and glances produced similar conservative monitoring-day recommendations. RESULTS: Single-day ICCs were 0.69 (95% CI 0.63-0.76) for Android Chronicle and 0.71 (95% CI 0.65-0.77) for iOS Screenshot data. Point-estimate projections indicated that 2 monitoring days were sufficient to achieve an ICC>/=0.80 for both data sources. Using the more conservative criterion that the lower bound of the projected 95% CI exceeded 0.80, 3 monitoring days were required for both Android and iOS data. Screen time was significantly lower on weekends than on weekdays, suggesting that monitoring periods should include at least 1 weekend day. CONCLUSIONS: Among caregivers of preschool-aged children, relatively short objective monitoring periods may provide reliable estimates of average daily smartphone screen time within a 7-day monitoring period. Two monitoring days were sufficient under point-estimate projections, whereas 3 days were required using a conservative lower-bound criterion. These findings support the feasibility of brief smartphone monitoring protocols for estimating the 7-day average duration, while emphasizing the importance of including weekend representation and avoiding the extension of these estimates to longer-term habitual smartphone behavior or screen time metrics beyond duration without further evidence. CI - (c) Joshua Culverhouse, Taylor Adair, Meghan Restino, Heidi M Weeks, Jenny S Radesky, R Glenn Weaver, Sarah Burkart, Hannah Parker, Olivia L Finnegan, Anthony J Holmes, Keagan Kiely, Rahul Ghosal, Srihari Nelakuditi, Michael W Beets, Bridget Armstrong. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org). FAU - Culverhouse, Joshua AU - Culverhouse J AUID- ORCID: 0000-0001-5345-5760 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Adair, Taylor AU - Adair T AUID- ORCID: 0009-0008-8045-9984 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Restino, Meghan AU - Restino M AUID- ORCID: 0009-0004-1557-2471 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Weeks, Heidi M AU - Weeks HM AUID- ORCID: 0000-0003-3467-7987 AD - University of Michigan School of Public Health, Ann Arbor, MI, United States. FAU - Radesky, Jenny S AU - Radesky JS AUID- ORCID: 0000-0002-7721-7350 AD - University of Michigan Medical School, Ann Arbor, MI, United States. FAU - Weaver, R Glenn AU - Weaver RG AUID- ORCID: 0000-0001-5889-974X AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Burkart, Sarah AU - Burkart S AUID- ORCID: 0000-0002-0840-1680 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Parker, Hannah AU - Parker H AUID- ORCID: 0000-0003-4197-7224 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Finnegan, Olivia L AU - Finnegan OL AUID- ORCID: 0000-0003-0625-1479 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Holmes, Anthony J AU - Holmes AJ AUID- ORCID: 0000-0003-4711-629X AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Kiely, Keagan AU - Kiely K AUID- ORCID: 0009-0008-0015-3484 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Ghosal, Rahul AU - Ghosal R AUID- ORCID: 0000-0003-0939-4731 AD - Department of Epidemiology and Biostatistics, University of South Carolina, Columbia, SC, United States. FAU - Nelakuditi, Srihari AU - Nelakuditi S AUID- ORCID: 0000-0001-5990-394X AD - Department of Computer Science and Engineering, University of South Carolina, Columbia, SC, United States. FAU - Beets, Michael W AU - Beets MW AUID- ORCID: 0000-0001-6728-6742 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. FAU - Armstrong, Bridget AU - Armstrong B AUID- ORCID: 0000-0002-1909-8170 AD - Department of Exercise Science, University of South Carolina, PHRC - Room 140, 921 Assembly St, Columbia, SC, 29201, United States, 1 8032017927. LA - eng GR - P20 GM130420/GM/NIGMS NIH HHS/United States GR - R01 HD112311/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260910 PL - Canada TA - JMIR Mhealth Uhealth JT - JMIR mHealth and uHealth JID - 101624439 SB - IM MH - Humans MH - *Smartphone/statistics & numerical data/instrumentation/standards MH - Reproducibility of Results MH - *Caregivers/statistics & numerical data/psychology MH - Child, Preschool MH - *Screen Time MH - Female MH - Male MH - Time Factors PMC - PMC13561401 OTO - NOTNLM OT - passive sensing OT - reliability OT - sampling duration OT - screen time OT - smartphone COIS- Conflicts of Interest: The authors declare no conflicts of interest. EDAT- 2026/09/10 17:42 MHDA- 2026/09/10 17:43 PMCR- 2026/09/10 CRDT- 2026/09/10 15:53 PHST- 2025/08/22 00:00 [received] PHST- 2026/07/17 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/09/10 17:43 [medline] PHST- 2026/09/10 17:42 [pubmed] PHST- 2026/09/10 15:53 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - v14i1e82846 [pii] AID - 82846 [pii] AID - 10.2196/82846 [doi] PST - epublish SO - JMIR Mhealth Uhealth. 2026 Sep 10;14:e82846. doi: 10.2196/82846. PMID- 42721394 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260910 LR - 20260910 IS - 2757-6256 (Print) IS - 2757-6256 (Linking) VI - 61 IP - 9 DP - 2026 Jul 6 TI - Does Body Fat Mass Influence the Timing of Puberty in Boys with Constitutional Delay of Growth and Puberty? PG - 815-821 LID - 10.65717/TurkArchPediatr.2026.25450 [doi] AB - OBJECTIVE: In girls, a strong relationship exists between body fat percentage (BFP) and pubertal development, with a critical fat threshold considered essential for the initiation of puberty. In contrast, research addressing the impact of body composition on the timing of puberty in boys remains limited, and the available findings are inconsistent. To evaluate the association between body composition and delayed pubertal development in boys with constitutional delay of growth and puberty (CDGP) compared with healthy peers. METHODS: Thirty-one boys with CDGP and 31 age-matched healthy males (Tanner stage 2-4) were included. Body composition was assessed using bioelectrical impedance analysis. Body fat percentage (BFP), fat mass (FM), fat-free mass (FFM), fat mass index (FMI), and fat-free mass index (FFMI) were evaluated. A BFP value of 17% was used as a descriptive reference rather than a validated biological cut-off. RESULTS: The mean chronological age was 14.1 +/- 0.5 years in the CDGP group and 13.9 +/- 1.1 years in the control group (P = .4). Compared with controls, boys with CDGP had significantly lower body mass index (BMI) standard deviation (SD) scores (P = .01). FM and FM SD scores were also significantly lower (both P = .002), and BFP was reduced (P = .03). No significant difference in BFP SD score was observed between groups (P > .05). The FFM/FM ratio was higher in the CDGP group (P = .04). FMI, FMI SD score, FFMI, and FFMI SD score were all significantly lower in boys with CDGP (P = .02, P = .02, P = .009, and P = .009, respectively). A BFP below 17% was observed in 58.1% of CDGP patients compared with 9.7% of controls (P < .001). CONCLUSION: Lower BMI, FM, and FFMI were associated with delayed pubertal onset in boys with CDGP, suggesting a potential relationship between reduced adiposity, lean mass, and the timing of pubertal development. CI - Content of this journal is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License. Copyright (c) Author(s) - Available online at https://turkarchpediatr.org/EN. Published by the Turkish Pediatrics Association. FAU - Kagizmanli, Gozde Akin AU - Kagizmanli GA AUID- ORCID: 0000-0002-6158-9002 AD - Department of Pediatric Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkiye. FAU - Demir, Korcan AU - Demir K AUID- ORCID: 0000-0002-8334-2422 AD - Department of Pediatric Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkiye. FAU - Bober, Ece AU - Bober E AUID- ORCID: 0000-0001-8828-0892 AD - Department of Pediatric Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkiye. FAU - Abaci, Ayhan AU - Abaci A AUID- ORCID: 0000-0002-1812-0321 AD - Department of Pediatric Endocrinology, Dokuz Eylul University Faculty of Medicine, Izmir, Turkiye. LA - eng PT - Journal Article DEP - 20260706 PL - Turkey TA - Turk Arch Pediatr JT - Turkish archives of pediatrics JID - 101776822 OTO - NOTNLM OT - Adiposity OT - body composition OT - delayed puberty OT - fat mass OT - male OT - pubertal onset COIS- The authors have no conflicts of interest to declare. EDAT- 2026/09/10 17:42 MHDA- 2026/09/10 17:43 CRDT- 2026/09/10 15:53 PHST- 2026/09/10 17:43 [medline] PHST- 2026/09/10 17:42 [pubmed] PHST- 2026/09/10 15:53 [entrez] AID - 10.65717/TurkArchPediatr.2026.25450 [doi] PST - epublish SO - Turk Arch Pediatr. 2026 Jul 6;61(9):815-821. doi: 10.65717/TurkArchPediatr.2026.25450. PMID- 42720508 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260915 IS - 1460-2245 (Electronic) IS - 0957-4824 (Print) IS - 0957-4824 (Linking) VI - 41 IP - 5 DP - 2026 Sep 1 TI - A realist inspired barriers and facilitators evaluation of the co-creation process in the Youth-centred Participatory Action Project. LID - 10.1093/heapro/daag134 [doi] LID - daag134 AB - This study examined barriers and facilitators of the first phase of the co-creation process as part of the Youth-centred Participatory Action (YoPA) project, a multi-country co-creation initiative to address health inequities by engaging adolescents in Denmark, Nigeria, South Africa, and the Netherlands. Using a qualitative design informed by implementation science and realist thinking, we analysed data from 22 transcripts of semi-structured interviews with researchers, facilitators, and external stakeholders, alongside 61 logbooks from co-creation sessions. Data were coded deductively using the PROSECO process-evaluation framework, followed by the development of exploratory Context-Mechanism-Outcome configurations. Findings highlight four predominant areas shaping the co-creation process: group dynamics, partnerships, contextual influences, and resources and support. Facilitators included psychologically safe spaces, horizontal communication, consistent facilitation, strong institutional partnerships, motivation driven by purpose and belonging, and access to organizational resources and staff support. Barriers were associated with socioeconomic adversity, unstable infrastructures, logistical constraints, competing priorities, uneven engagement, and challenges in translating complex systems-thinking concepts into youth-friendly practice. Realist interpretations suggest that when structured participation, trust, and relational support were present, they activated mechanisms of ownership, agency, and sustained engagement; conversely, low-resource contexts and activities overload hindered participation, feasibility, and engagement. This study contributes empirical evidence on co-creation processes with adolescents across diverse settings. It demonstrates the combined value of the PROSECO framework and realist-inspired analysis for evaluation and understanding of how context and mechanisms shape co-creation in health-related research. Implications include the need for resourcing relational work, and designing context-sensitive strategies when conducting co-creation with adolescents. CI - (c) The Author(s) 2026. Published by Oxford University Press. FAU - Souza, Maria Fernanda S AU - Souza MFS AUID- ORCID: 0000-0002-4135-8549 AD - Research Center in Sports, Physical Education, Exercise and Health (CIDEFES), Universidade Lusofona, Campo Grande, 376, Lisboa 1749-024, Portugal. AD - CIFI2D, Faculdade de Desporto, Universidade do Porto, Rua Dr. Placido Costa 91, Porto 4200-450, Portugal. FAU - Chinapaw, Mai AU - Chinapaw M AUID- ORCID: 0000-0001-6259-2441 AD - Public and Occupational Health, Amsterdam UMC Location VUmc, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. FAU - Silva, Catarina Santos AU - Silva CS AUID- ORCID: 0000-0001-9464-7064 AD - Research Center in Sports, Physical Education, Exercise and Health (CIDEFES), Universidade Lusofona, Campo Grande, 376, Lisboa 1749-024, Portugal. AD - CIFI2D, Faculdade de Desporto, Universidade do Porto, Rua Dr. Placido Costa 91, Porto 4200-450, Portugal. FAU - Demetriadou, Leto AU - Demetriadou L AUID- ORCID: 0000-0002-2620-9932 AD - Public and Occupational Health, Amsterdam UMC Location VUmc, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. FAU - Madsen, Line AU - Madsen L AUID- ORCID: 0009-0005-4539-3842 AD - Department of Sports Science and Biomechanics, Faculty of Health Sciences, Southern Denmark University, Campusvej, 55, Odense M DK52-30, Denmark. FAU - Maluleke, Vongani AU - Maluleke V AUID- ORCID: 0009-0004-8426-4632 AD - Department of Paediatrics, School of Clinical Medicine, University of the Witwatersrand, Wits Medical School, 7 York Road, Parktown, Johannesburg 2193, South Africa. FAU - Ndwandwe, Lethukuthula AU - Ndwandwe L AUID- ORCID: 0009-0005-1373-960X AD - Department of Paediatrics, School of Clinical Medicine, University of the Witwatersrand, Wits Medical School, 7 York Road, Parktown, Johannesburg 2193, South Africa. FAU - Okafor, Anita AU - Okafor A AUID- ORCID: 0000-0003-4510-1553 AD - Department of Physiotherapy, Redeemer's University, off Gbongan - Oshogbo Road, Ede, Osun State 232101, Nigeria. FAU - Ogunleye, Adefunke AU - Ogunleye A AUID- ORCID: 0009-0008-2821-6811 AD - Gender and Education Department, Value Re-Orientation for Community Enhancement (VARCE), 25, Bola Famoyin Lane, Dada State, Osogbo, Osun State 230261, Nigeria. FAU - Vargas, Jesse AU - Vargas J AD - Public and Occupational Health, Amsterdam UMC Location VUmc, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. FAU - Longworth, Giuliana AU - Longworth G AUID- ORCID: 0000-0001-9063-4821 AD - School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, Cowcaddens Road, Glasgow G4 0BA, United Kingdom. FAU - Altenburg, Teatske AU - Altenburg T AUID- ORCID: 0000-0002-8764-5631 AD - Public and Occupational Health, Amsterdam UMC Location VUmc, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. FAU - Klaufus, Leonie AU - Klaufus L AUID- ORCID: 0000-0001-9878-3530 AD - Public and Occupational Health, Amsterdam UMC Location VUmc, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. FAU - Omotoso, Dayo AU - Omotoso D AUID- ORCID: 0000-0002-4467-2955 AD - Department of Anatomy, Redeemer's University, off Gbongan - Oshogbo Road, Ede, Osun State 232101, Nigeria. FAU - Oyeyemi, Adewale AU - Oyeyemi A AUID- ORCID: 0000-0002-3737-2911 AD - College of Health Solutions, Arizona State University, 550 N, 3rd Street, Health North Building, Suite 501, Phoenix, AZ 85004, United States. FAU - Ware, Lisa AU - Ware L AUID- ORCID: 0000-0002-9762-4017 AD - Department of Paediatrics, School of Clinical Medicine, University of the Witwatersrand, Wits Medical School, 7 York Road, Parktown, Johannesburg 2193, South Africa. FAU - Palmeira, Antonio AU - Palmeira A AUID- ORCID: 0000-0001-6508-0599 AD - Research Center in Sports, Physical Education, Exercise and Health (CIDEFES), Universidade Lusofona, Campo Grande, 376, Lisboa 1749-024, Portugal. AD - CIFI2D, Faculdade de Desporto, Universidade do Porto, Rua Dr. Placido Costa 91, Porto 4200-450, Portugal. FAU - Silva, Marlene N AU - Silva MN AUID- ORCID: 0000-0003-4734-0283 AD - Research Center in Sports, Physical Education, Exercise and Health (CIDEFES), Universidade Lusofona, Campo Grande, 376, Lisboa 1749-024, Portugal. AD - CIFI2D, Faculdade de Desporto, Universidade do Porto, Rua Dr. Placido Costa 91, Porto 4200-450, Portugal. LA - eng GR - WT_/Wellcome Trust/United Kingdom GR - 301436/Z/23/Z/Wellcome Trust UK/ GR - 101095423/Horizon Europe/ PT - Journal Article PL - England TA - Health Promot Int JT - Health promotion international JID - 9008939 SB - IM MH - Humans MH - Adolescent MH - Nigeria MH - South Africa MH - Denmark MH - *Health Promotion/organization & administration/methods MH - Netherlands MH - Qualitative Research MH - Community-Based Participatory Research MH - Group Dynamics PMC - PMC13560076 OTO - NOTNLM OT - adolescents OT - co-creation OT - health inequities OT - movement behaviours OT - participatory research OT - physical activity OT - realist thinking COIS- The authors report there are no competing interests to declare. EDAT- 2026/09/10 11:53 MHDA- 2026/09/10 11:54 PMCR- 2026/09/10 CRDT- 2026/09/10 10:03 PHST- 2026/09/10 11:54 [medline] PHST- 2026/09/10 11:53 [pubmed] PHST- 2026/09/10 10:03 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - 8789919 [pii] AID - daag134 [pii] AID - 10.1093/heapro/daag134 [doi] PST - ppublish SO - Health Promot Int. 2026 Sep 1;41(5):daag134. doi: 10.1093/heapro/daag134. PMID- 42720098 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20261015 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) VI - 9 IP - 9 DP - 2026 Sep 10 TI - Iodine supplementation for preventing iodine deficiency disorders in children and adolescents. PG - CD014475 LID - 10.1002/14651858.CD014475.pub2 [doi] LID - CD014475 AB - RATIONALE: Iodine is a micronutrient crucial in the early stages of human development, as it is essential for synthesising thyroid hormones involved in somatic growth and neurodevelopment. It is far better to prevent iodine deficiency than to treat it, since children are particularly vulnerable to iodine deficiency disorders, which involve a broad spectrum of consequences including endemic goitre, delayed growth and development of the central nervous system, intellectual impairment, and infant mortality. The primary dietary sources of iodine are iodised salt, seafood (animals and plants concentrate iodine from seawater), and grains from iodine-rich soils. Reliable evidence is needed on the benefits and harms of direct iodine supplementation in children and adolescents before considering its use to prevent the health consequences of iodine deficiency. OBJECTIVES: To assess the benefits and harms of iodine supplementation for preventing iodine deficiency in children and adolescents. SEARCH METHODS: We searched CENTRAL, MEDLINE, eight other databases, and two trials registries to 8 May 2025. We also searched the reference lists of retrieved studies. ELIGIBILITY CRITERIA: We included randomised controlled trials (RCTs) evaluating the benefits and harms of iodine supplementation alone (orally or by injection) or in combination with vitamins and minerals (orally or by injection) compared with placebo. OUTCOMES: Our critical outcomes were cognitive function assessed by validated scales, growth, hypothyroidism, and adverse events. Important outcomes included health-related quality of life, all-cause mortality, and goitre. RISK OF BIAS: We used the Cochrane RoB 2 tool to assess the risk of bias in the included studies. SYNTHESIS METHODS: Two review authors independently selected trials, extracted data, and assessed risk of bias. We used random-effects meta-analysis to combine data. We assessed the certainty of the evidence using GRADE. INCLUDED STUDIES: We included eight RCTs with a total of 2528 participants. The trials were conducted in seven countries between 1982 and 2009. The trials compared iodine supplementation (alone or with iron in one study) versus placebo. In one study, iodine supplementation was 150 mug daily for 28 weeks, while in the remaining studies, iodine supplementation was done in a single dose: 100 mg in a study on infants younger than 1 year, and a dose between 400 mg and 490 mg for children 6 to 17 years. Follow-up ranged from 3 to 22 months. SYNTHESIS OF RESULTS: Iodine supplementation versus placebo Iodine supplementation results in a slight increase in cognitive function compared to placebo (standardised mean difference 0.19, 95% confidence interval (CI) 0.04 to 0.34; 1 study, 166 participants; high-certainty evidence). Iodine supplementation may result in little to no difference in children's weight (kg) compared to placebo (mean difference (MD) -0.20, 95% CI -1.92 to 1.52; I(2) = 44%; 3 studies, 658 participants; low-certainty evidence). We downgraded the certainty of evidence by one level for imprecision and one level for heterogeneity. Iodine supplementation likely results in a large reduction in hypothyroidism compared to placebo (risk ratio (RR) 0.03, 95% CI 0.00 to 0.23; 1 study, 264 participants; moderate-certainty evidence). We downgraded the certainty of evidence by one level for risk of bias. No study reported adverse events related to iodine or quality of life. Iodine supplementation likely reduces all-cause mortality in infants compared to placebo (RR 0.32, 95% CI 0.14 to 0.73; 1 study, 617 participants; moderate-certainty evidence). We downgraded the certainty of evidence by one level for risk of bias. The evidence is very uncertain about the effect of iodine supplementation on the reduction of goitre (RR 0.68, 95% CI 0.15 to 3.07; I(2) = 97%; 2 studies, 432 participants; very low-certainty evidence). We downgraded the certainty of evidence by one level for imprecision, one level for heterogeneity, and one level for risk of bias. However, a sensitivity analysis removing the study with high risk of bias showed that iodine likely results in a large reduction in goitre (RR 0.31, 95% CI 0.22 to 0.45; 1 study, 230 participants; moderate-certainty evidence). Iodine plus iron supplementation versus placebo Iodine plus iron supplementation was compared to placebo in a single study. The evidence is very uncertain about the effect of iodine plus iron on weight (MD -0.40, 95% CI -1.44 to 0.64; 1 study, 146 participants; very low-certainty evidence). We downgraded the certainty of evidence by two levels for imprecision and one level for risk of bias. No other outcomes were assessed for this comparison. AUTHORS' CONCLUSIONS: Iodine supplementation, in the doses and follow-up periods evaluated in published RCTs, results in a slight increase in cognitive function and may result in little to no difference in growth. It likely reduces hypothyroidism and the risk of death in infants, but the evidence is very uncertain about its effect on the reduction of goitre. Future studies should focus on areas or populations in which iodine deficiency could be a problem, and include children of lower socioeconomic levels. They should evaluate higher doses of iodine administered during longer periods of treatment and follow-up times. FUNDING: This Cochrane review had no dedicated funding. REGISTRATION: Protocol (2023). DOI: 10.1002/14651858.CD014475. CI - Copyright (c) 2026 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. FAU - Velasco, Ines AU - Velasco I AUID- ORCID: 0000-0002-6143-6970 AD - Obstetrics and Gynecology, University Hospital Germans Trias i Pujol, Badalona, Spain. FAU - Rueda-Etxebarria, Mikel AU - Rueda-Etxebarria M AUID- ORCID: 0000-0002-4341-9245 AD - Free time independent Cochrane reviewer, Biobizkaia Health Research Institute, Cruces University Hospital, Bilbao, Spain. FAU - Trak-Fellermeier, Maria Angelica AU - Trak-Fellermeier MA AUID- ORCID: 0000-0003-2152-2935 AD - Department of Dietetics and Nutrition, Florida International University / Global Nutrition Professionals, Miami, Florida, USA. FAU - Taylor, Peter AU - Taylor P AUID- ORCID: 0000-0002-3436-422X AD - Thyroid Research Group, Division of Infection and Immunity, Cardiff University, Cardiff, UK. FAU - Rabassa Bonet, Montserrat AU - Rabassa Bonet M AUID- ORCID: 0000-0002-0276-6726 AD - Iberoamerican Cochrane Centre, Biomedical Research Institute Sant Pau (IIB Sant Pau), Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. AD - Nutrition and Food Safety Research Institute (INSA-UB), Facultat de Farmacia i Ciencies de l'Alimentacio, Universitat de Barcelona, Barcelona, Spain. FAU - Chi, Yuan AU - Chi Y AUID- ORCID: 0009-0000-9745-2019 AD - Yealth Network, Beijing Yealth Technology Co., Ltd, Beijing, China. AD - Department of Health Research Methods, Evidence, & Impact, McMaster University, Hamilton, Canada. FAU - Janka, Heidrun AU - Janka H AUID- ORCID: 0000-0002-8677-4036 AD - Institute of General Practice, Medical Faculty of the Heinrich Heine University Dusseldorf, Dusseldorf, Germany. FAU - Rueda, Jose-Ramon AU - Rueda JR AUID- ORCID: 0000-0003-3560-7315 AD - Department of Preventive Medicine and Public Health, University of the Basque Country, Leioa, Spain. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260910 PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 RN - 9679TC07X4 (Iodine) RN - 0 (Trace Elements) SB - IM UOF - doi: 10.1002/14651858.CD014475 MH - Adolescent MH - Child MH - Child, Preschool MH - Humans MH - Infant MH - Cognition/drug effects MH - Deficiency Diseases/prevention & control MH - *Dietary Supplements/adverse effects MH - Hypothyroidism/prevention & control MH - *Iodine/deficiency/administration & dosage/adverse effects MH - Quality of Life MH - Randomized Controlled Trials as Topic MH - *Trace Elements/administration & dosage PMC - PMC13559954 COIS- Ines Velasco (IV): none known. Mikel Rueda-Etxebarria (MRE): none known. Maria Angelica Trak-Fellermeier (MTF): none known. Peter Taylor (PT): none known. Montserrat Rabassa Bonet (MRB): none known. Yuan Chi (YC): none known. Heidrun Janka (HJ): none known. HJ is a member of the Cochrane Metabolic and Endocrine Disorders Group, but she was not involved in the editorial process of the review. Jose-Ramon Rueda (JRR): none known. EDAT- 2026/09/10 11:53 MHDA- 2026/09/10 11:54 PMCR- 2027/09/10 CRDT- 2026/09/10 09:02 PHST- 2026/09/10 11:54 [medline] PHST- 2026/09/10 11:53 [pubmed] PHST- 2026/09/10 09:02 [entrez] PHST- 2027/09/10 00:00 [pmc-release] AID - CD014475.pub2 [pii] AID - 10.1002/14651858.CD014475.pub2 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2026 Sep 10;9(9):CD014475. doi: 10.1002/14651858.CD014475.pub2. PMID- 42717780 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260917 IS - 1365-2214 (Electronic) IS - 0305-1862 (Print) IS - 0305-1862 (Linking) VI - 52 IP - 5 DP - 2026 Sep TI - Intervention to Improve Running and Physical Activity Participation in Children With Generalised Joint Hypermobility: A Feasibility Study. PG - e70345 LID - 10.1111/cch.70345 [doi] LID - e70345 AB - BACKGROUND: Children with symptomatic paediatric generalised joint hypermobility (pgGJH) have limitations in physical activity and participation, yet there is a lack of research to guide intervention. In Australia, these children do not receive funding support. The objective of this study was to investigate the feasibility of a programme delivered in a private practice to improve running and associated goals of children with pgGJH from the perspectives of children, parents and staff. METHODS: Children with pgGJH undertook a weekly group running intervention and home exercise programme (HEP) for 10 weeks. Feasibility of delivery in a private paediatric therapy clinic was determined using physical and self-reported measures for acceptability, demand, implementation, practicality, integration and intervention efficacy. Semi-structured interviews with participants, therapists and managers explored multiple aspects of feasibility of the programme. RESULTS: Acceptability: satisfaction was rated between 6.5 and 9/10. Demand: 155 of 175 survey respondents were interested in the programme. Recruitment saw 24 participants invited, 10 excluded and 6 declined. Eight children aged 10-15 years (two female) participated and attended >/= 90% of sessions. The HEP was completed at least twice per week by 62% of participants. IMPLEMENTATION: the intervention was completed according to the protocol with one minor adverse event. Practicality: the intervention was well equipped but expensive to run with a therapist to participant ratio of 1:3. Integration: interventionists perceived the programme to fit well within the practice infrastructure and culture. EFFICACY: participants and parents reported improved running technique and increased confidence in physical activity. Leg stiffness improved and kinesiophobia was reduced. CONCLUSION: A running intervention for children with pgGJH was acceptable, in demand, practical to deliver and able to be integrated and implemented in a private clinic. Cost was the main challenge identified by families and management. CI - (c) 2026 The Author(s). Child: Care, Health and Development published by John Wiley & Sons Ltd. FAU - Chappell, Annie AU - Chappell A AUID- ORCID: 0000-0001-7092-8662 AD - School of Allied Health, Curtin University, Bentley, Western Australia, Australia. AD - Western Kids Health, Shenton Park, Western Australia, Australia. AD - School of Human Movement and Nutrition Sciences, The University of Queensland, St Lucia, Queensland, Australia. FAU - Jepson, Beverly AU - Jepson B AD - School of Allied Health, Curtin University, Bentley, Western Australia, Australia. AD - Western Kids Health, Shenton Park, Western Australia, Australia. FAU - Kilgour, Gaela AU - Kilgour G AUID- ORCID: 0000-0002-8867-7782 AD - Department of Physiotherapy, University of Melbourne, Parkville, Victoria, Australia. AD - Child Health Research Centre, University of Queensland, St Lucia, Queensland, Australia. LA - eng PT - Journal Article PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM MH - Humans MH - Child MH - Female MH - Feasibility Studies MH - Male MH - *Joint Instability/rehabilitation/physiopathology/psychology MH - *Running/physiology MH - Adolescent MH - *Exercise Therapy/methods MH - Patient Satisfaction MH - Australia PMC - PMC13559497 OTO - NOTNLM OT - feasibility OT - hypermobility OT - intervention OT - motor skill OT - physical activity OT - running COIS- Annie Chappell and Beverly Jepson were employees of Western Kids Health at the time of the study. Neither Curtin University nor Western Kids Health had any role in the planning or analysis of the study. EDAT- 2026/09/10 11:53 MHDA- 2026/09/10 11:54 PMCR- 2026/09/10 CRDT- 2026/09/10 05:16 PHST- 2026/08/20 00:00 [revised] PHST- 2026/04/24 00:00 [received] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/09/10 11:54 [medline] PHST- 2026/09/10 11:53 [pubmed] PHST- 2026/09/10 05:16 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - CCH70345 [pii] AID - 10.1111/cch.70345 [doi] PST - ppublish SO - Child Care Health Dev. 2026 Sep;52(5):e70345. doi: 10.1111/cch.70345. PMID- 42717667 OWN - NLM STAT- Publisher LR - 20260910 IS - 1613-6829 (Electronic) IS - 1613-6810 (Linking) DP - 2026 Sep 9 TI - Bioelectronic Wearable Sensors Produced by Computerized Embroidery Using a Dual Thread Approach. PG - e75624 LID - 10.1002/smll.75624 [doi] AB - Electronic textiles offer a promising route to wearable systems capable of continuous biophysical and biochemical monitoring. Their broader adoption remains limited by conductive threads that rarely support computerized embroidery (CEmb), reliable electronic integration, and reduced electrochemical capabilities due to coatings that degrade under bending, friction, or aqueous exposure. In this work, we use a dual-thread strategy that integrates silver-plated polyamide threads (AgPT) for high-conductivity pathways with PECOTEX, a chemically resilient PEDOT:PSS-coated cotton thread optimized for biochemical sensing. This approach preserves compatibility with CEmb, enhances electrochemical performance, and reduces cost by reserving AgPT for critical traces. We demonstrate a CEmb-compatible fabrication process for two wearable devices: a fully embroidered SmartBra for electrocardiography and a two-electrode ion sensor for potassium and sodium detection. We validate the design of our wearable dual-thread biosensors through laboratory characterization experiments and evaluate electrochemical sensing performance using a breast milk substitute, enabling realistic testing within women's health and infant-nutrition contexts. By focusing on scalable fabrication and meaningful applications, this work advances embroidered electronic textile systems toward practical, personalized healthcare monitoring. CI - (c) 2026 The Author(s). Small published by Wiley-VCH GmbH. FAU - Weinstein, Taliya AU - Weinstein T AUID- ORCID: 0000-0002-1443-2117 AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. FAU - Li, Xintong AU - Li X AUID- ORCID: 0009-0009-1941-1700 AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. FAU - Kurt, Hasan AU - Kurt H AUID- ORCID: 0000-0002-1677-644X AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. FAU - Olenik, Selin AU - Olenik S AUID- ORCID: 0000-0002-8533-0169 AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. FAU - Collins, Alexander Silva-Pinto AU - Collins AS AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. FAU - Flauzino, Jose Manuel Rodrigueiro AU - Flauzino JMR AUID- ORCID: 0000-0002-0437-4435 AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. FAU - Adeel, Muhammed AU - Adeel M AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. FAU - Gonzalez-Macia, Laura AU - Gonzalez-Macia L AUID- ORCID: 0000-0003-1372-7965 AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. FAU - Yuce, Meral AU - Yuce M AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. AD - SUNUM Nanotechnology Research and Application Center, Sabanci University, Istanbul, Turkiye. FAU - Guder, Firat AU - Guder F AD - Department of Bioengineering, Royal School of Mines, Imperial College London, London, UK. LA - eng GR - OPP1212574/Cytiva, Imperial College London, Department of Bioengineering, Gates Foundation/ GR - INV-038695/Cytiva, Imperial College London, Department of Bioengineering, Gates Foundation/ GR - W911QY-20-R-0022/US Army (U.S. Army Foreign Technology (and Science) Assessment Support program/ GR - 207687/Z/17/Z/WT_/Wellcome Trust/United Kingdom GR - 10004425/Innovate UK/ GR - 101111321/EU Horizon Europe Marie Sklodowska-Curie fellowship/ GR - 101025390/EU Horizon Europe Marie Sklodowska-Curie fellowship/ GR - EP/Y030273/1/UKRI MSCA fellowship/ GR - EP/G037515/1/EPSRC/ GR - EP/L016702/1/EPSRC/ PT - Journal Article DEP - 20260909 PL - Germany TA - Small JT - Small (Weinheim an der Bergstrasse, Germany) JID - 101235338 SB - IM OTO - NOTNLM OT - computerized embroidery OT - conductive cotton thread OT - electrochemical sensing OT - embroidered electronics OT - wearable electrocardiogram EDAT- 2026/09/10 11:53 MHDA- 2026/09/10 11:53 CRDT- 2026/09/10 05:09 PHST- 2026/08/04 00:00 [revised] PHST- 2026/03/30 00:00 [received] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/10 11:53 [medline] PHST- 2026/09/10 11:53 [pubmed] PHST- 2026/09/10 05:09 [entrez] AID - 10.1002/smll.75624 [doi] PST - aheadofprint SO - Small. 2026 Sep 9:e75624. doi: 10.1002/smll.75624. PMID- 42717323 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260916 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Aug 14 TI - Psychometric properties of the Turkish version of the Preschool Eating, Lifestyle, and Sleeping Attitudes (PRELSA) scale. LID - 10.1186/s12887-026-07532-9 [doi] LID - 847 AB - BACKGROUND: Childhood obesity in preschool years is strongly influenced by modifiable parental attitudes and behaviors. This study examined the validity and reliability of the Turkish version of the Preschool Eating, Lifestyle, and Sleeping Attitudes (PRELSA) Scale, which assesses parental attitudes related to childhood obesity during the preschool period. METHODS: This methodological study was conducted with 460 parents of children aged 2-6 years from seven preschools in Central Anatolia, Turkiye. Data were collected using a family and child information form and the PRELSA Scale. The adaptation process included forward-backward translation, expert review, face validity assessment, and psychometric evaluation. Data were analyzed using exploratory and confirmatory factor analyses, Cronbach's alpha, test-retest reliability, and intraclass correlation coefficients (ICC). RESULTS: The Turkish version comprised 39 items across 13 subscales. The overall Cronbach's alpha coefficient was 0.887. Exploratory factor analysis explained 58.5% of the total variance, with factor loadings ranging from 0.353 to 0.890. Confirmatory factor analysis indicated acceptable model fit (chi(2)/df = 1.434, RMSEA = 0.031, SRMR = 0.046, CFI = 0.904, IFI = 0.907, GFI = 0.911, TLI = 0.888). Test-retest reliability was high (r = 0.911), and the ICC was 0.865 (95% CI: 0.738-0.933), indicating good temporal stability. CONCLUSION: The Turkish PRELSA Scale is a valid and reliable instrument for assessing parental attitudes toward eating behaviors, physical activity, screen use, and sleep routines in early childhood. CI - (c) 2026. The Author(s). FAU - Bolacali, Edanur Tar AU - Bolacali ET AUID- ORCID: 0000-0001-8821-8554 AD - Faculty of Health Sciences, Department of Children Health and Disease Nursing, Kirsehir Ahi Evran University, Kirsehir, Turkiye. edanur.tar@ahievran.edu.tr. FAU - Bolacali, Memis AU - Bolacali M AUID- ORCID: 0000-0002-4196-2359 AD - Faculty of Medicine, Department of Biostatistics and Medical Informatics, Kirsehir Ahi Evran University, Kirsehir, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20260814 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Child, Preschool MH - Turkey MH - Male MH - Psychometrics MH - Female MH - Reproducibility of Results MH - Child MH - *Parents/psychology MH - *Life Style MH - *Sleep MH - Surveys and Questionnaires MH - *Pediatric Obesity/psychology/prevention & control MH - Factor Analysis, Statistical MH - *Feeding Behavior/psychology MH - *Attitude to Health PMC - PMC13560222 OTO - NOTNLM OT - Childhood obesity OT - Parents OT - Preschool child OT - Psychometrics OT - Validation study COIS- Declarations. Ethics approval and consent to participate: Written permission for the Turkish adaptation and use of the PRELSA Scale was obtained via email from corresponding author Carretero-Bravo on September 12, 2024. Before starting the study, ethical committee approval was obtained from the Scientific Research and Publication Ethics Committee of Kirsehir Ahi Evran University Faculty of Social and Human Sciences on February 26, 2025, with the number 2025/04/18. In addition, institutional permission for data collection was obtained from the Kirsehir Provincial Directorate of National Education on February 26, 2025, with the number MEB.TT.2025.019400. Prior to data collection, eligible parents were provided with detailed information about the study, and written informed consent was obtained from those who agreed to participate. They were also advised that participation was voluntary and that they could withdraw from the study at any time without consequence. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/10 05:36 MHDA- 2026/09/10 05:37 PMCR- 2026/08/14 CRDT- 2026/09/10 04:40 PHST- 2026/03/09 00:00 [received] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/10 05:37 [medline] PHST- 2026/09/10 05:36 [pubmed] PHST- 2026/09/10 04:40 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - 10.1186/s12887-026-07532-9 [pii] AID - 7532 [pii] AID - 10.1186/s12887-026-07532-9 [doi] PST - epublish SO - BMC Pediatr. 2026 Aug 14;26(1):847. doi: 10.1186/s12887-026-07532-9. PMID- 42716646 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260921 IS - 1097-6752 (Electronic) IS - 0889-5406 (Linking) VI - 170 IP - 3 DP - 2026 Sep TI - Artificial intelligence-assisted analysis of tongue morphology and sagittal skeletal patterns: A multicenter study. PG - 415-424.e1 LID - S0889-5406(26)00189-7 [pii] LID - 10.1016/j.ajodo.2026.03.011 [doi] AB - INTRODUCTION: This study investigated the association between tongue morphology and sagittal skeletal patterns and assessed a deep learning model for automated tongue landmark detection and segmentation on lateral cephalometric radiographs (LCRs). METHODS: Pretreatment LCRs from 503 orthodontic patients (aged 6-40 years) were analyzed, categorized by dentition stage (mixed: 6-11; permanent: 12-40), and sagittal skeletal patterns. Tongue measurements were compared across subgroups. A multicenter dataset of 1179 LCRs trained a deep learning framework integrating U-Net for segmentation and RTMPose (real-time model for pose estimation) for landmark detection: tongue tip, dorsum of tongue, and base of the epiglottis. Model performance was assessed using mean radial error, success detection rate, mean intersection over union, and recall. External validation was performed on an independent hold-out dataset from 2 hospitals. RESULTS: In the permanent dentition group, subjects with Class Ⅲ malocclusion showed larger tongue areas than Class Ⅱ but not Class I; no significant differences in tongue area were observed in the mixed dentition group. The model achieved a mean radial error of 1.72 +/- 1.78 mm, success detection rates of 75.65% (/= 3.0). CONCLUSION: Children with ASD exhibited significant differences in gut microbiota composition compared with TD children, characterized by a functional compositional imbalance-systematic depletion of butyrate-producing bacteria and Bifidobacterium spp. alongside enrichment of specific Bacteroides members-rather than alterations in overall species diversity. These findings are consistent with gut-brain axis dysregulation in ASD, though the cross-sectional design precludes causal inference and the possibility that observed differences reflect ASD-related dietary behavior cannot be excluded. GMHI demonstrated superior discriminative performance compared with traditional diversity indices in this cohort, though its application in pediatric ASD populations remains exploratory and requires independent validation in larger multicenter cohorts. CI - Copyright (c) 2026 Kang, Fan, Tian, Jin, Zhang, Sun and Liu. FAU - Kang, Le AU - Kang L AD - Department of Hand Surgery & Microsurgery and Foot & Ankle Surgery, Yantai Affiliated Hospital of Shandong Medical and Pharmaceutical University, Yantai, China. FAU - Fan, Linlin AU - Fan L AD - Department of Child Health Care, Yantai Affiliated Hospital of Shandong Medical and Pharmaceutical University, Yantai, China. FAU - Tian, Ying AU - Tian Y AD - Department of Neonatology, Yantai Affiliated Hospital of Shandong Medical and Pharmaceutical University, Yantai, China. FAU - Jin, Jiayi AU - Jin J AD - School of Pharmacy, Shandong Medical and Pharmaceutical University, Yantai, China. FAU - Zhang, Na AU - Zhang N AD - Department of Gynecology, Jiaoqiao Central Health Center, Jiaoqiao, China. FAU - Sun, Caihong AU - Sun C AD - Department of Child Health Care, Yantai Affiliated Hospital of Shandong Medical and Pharmaceutical University, Yantai, China. FAU - Liu, Yang AU - Liu Y AD - School of Special Education and Rehabilitation, Shandong Medical and Pharmaceutical University, Yantai, China. LA - eng PT - Journal Article DEP - 20260825 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 EIN - Front Microbiol. 2026 Oct 13;17:2006584. doi: 10.3389/fmicb.2026.2006584. PMID: 42948388 PMC - PMC13552353 OTO - NOTNLM OT - 16S rRNA sequencing OT - autism spectrum disorder OT - case-control study OT - gut microbiota OT - microbial dysbiosis COIS- The author(s) declare that this research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 PMCR- 2026/08/25 CRDT- 2026/09/09 07:47 PHST- 2026/05/25 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 07:47 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.3389/fmicb.2026.1890167 [doi] PST - epublish SO - Front Microbiol. 2026 Aug 25;17:1890167. doi: 10.3389/fmicb.2026.1890167. eCollection 2026. PMID- 42713329 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260910 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Hypothalamic neuroimmune remodeling as an immunometabolic bridge between childhood obesity and earlier pubertal onset. PG - 1932785 LID - 10.3389/fimmu.2026.1932785 [doi] LID - 1932785 AB - While the link between childhood obesity and central precocious puberty (CPP) is well documented, the immune-mediated mechanisms that may precipitate earlier pubertal onset remain incompletely understood. This review proposes hypothalamic neuroimmune remodeling as a candidate immunometabolic bridge through which chronic low-grade peripheral inflammation may influence the timing of hypothalamic-pituitary-gonadal (HPG) axis activation. In obesity, systemic immune activation is primarily by adipose tissue macrophage infiltration, lipotoxic signaling, and gut dysbiosis. Peripheral inflammatory signals may reach the central nervous system through the arcuate nucleus-median eminence complex, disruption of the blood-brain barrier, and immune-mediated gut-brain pathways. Within the hypothalamus, these signals may elicit local neuroimmune responses. Glial cells, particularly microglia, astrocytes, and tanycytes, undergo inflammatory activation and release cytokines and lipid mediators, including IL-1beta, TNF-alpha, and prostaglandin E2. This localized neuroimmune response may alter the excitatory milieu and synaptic connectivity of the kisspeptin-GnRH network, thereby lowering the threshold for HPG axis activation. This review systematically synthesizes current evidence on this immune-endocrine crosstalk and describes how peripheral immune signals may remodel the hypothalamic microenvironment and alter pubertal timing. We further discuss the translational potential of targeting specific neuroimmune pathways for biomarker discovery and the development of novel immunomodulatory interventions for CPP. Although neuroimmune remodeling represents a plausible mechanism underlying obesity-associated pubertal advancement, its causal role requires further validation through targeted mechanistic studies and longitudinal immunophenotyping. CI - Copyright (c) 2026 Liu, Chen, Zhang, Peng, Lei and Liu. FAU - Liu, Ping AU - Liu P AD - Hubei University of Chinese Medicine, Wuhan, Hubei, China. AD - Hubei Shizhen Laboratory, Wuhan, Hubei, China. FAU - Chen, Yue AU - Chen Y AD - Hubei University of Chinese Medicine, Wuhan, Hubei, China. FAU - Zhang, Yujing AU - Zhang Y AD - Hubei University of Chinese Medicine, Wuhan, Hubei, China. AD - Hubei Shizhen Laboratory, Wuhan, Hubei, China. FAU - Peng, Yanhui AU - Peng Y AD - Hubei University of Chinese Medicine, Wuhan, Hubei, China. AD - Jianghan University Affiliated Hubei Third People's Hospital, Wuhan, Hubei, China. FAU - Lei, Enze AU - Lei E AD - Hubei Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, Hubei, China. FAU - Liu, Jianzhong AU - Liu J AD - Hubei University of Chinese Medicine, Wuhan, Hubei, China. AD - Hubei Shizhen Laboratory, Wuhan, Hubei, China. AD - Hubei Provincial Hospital of Traditional Chinese Medicine, Affiliated Hospital of Hubei University of Chinese Medicine, Wuhan, Hubei, China. LA - eng PT - Journal Article PT - Review DEP - 20260825 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 SB - IM MH - Humans MH - *Hypothalamus/immunology/metabolism MH - Hypothalamic-Pituitary-Gonadal Axis MH - Animals MH - *Pediatric Obesity/immunology/metabolism MH - *Neuroimmunomodulation MH - *Puberty, Precocious/immunology/metabolism MH - Child MH - Puberty/immunology PMC - PMC13551744 OTO - NOTNLM OT - HPG axis OT - central precocious puberty OT - childhood obesity OT - hypothalamic neuroimmune remodeling OT - kisspeptin-GnRH network OT - metaflammation OT - pubertal onset COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 PMCR- 2026/08/25 CRDT- 2026/09/09 07:34 PHST- 2026/07/09 00:00 [received] PHST- 2026/07/29 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 07:34 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1932785 [doi] PST - epublish SO - Front Immunol. 2026 Aug 25;17:1932785. doi: 10.3389/fimmu.2026.1932785. eCollection 2026. PMID- 42713310 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260921 IS - 1303-2968 (Electronic) IS - 1303-2968 (Linking) VI - 25 IP - 3 DP - 2026 Sep TI - Comparative Effects of Training Modalities on Countermovement Jump Performance in Soccer Players: A Systematic Review and Network Meta-Analysis. PG - 701-713 LID - 10.52082/jssm.2026.701 [doi] AB - The aim of this study was to provide a comprehensive comparison of training modalities for countermovement jump (CMJ) performance in soccer players using a network meta-analysis (NMA). PubMed, Web of Science, Embase, EBSCO, and the Cochrane Library were searched up to November 2025. Randomized controlled trials (RCTs) involving healthy soccer players, evaluating structured training interventions against comparator training or control conditions, and reporting CMJ height outcomes were included. A random-effects NMA was performed to estimate mean differences (MDs) with 95% confidence intervals (CIs), and interventions were ranked using P-scores, integrating both direct and indirect evidence. Subgroup analyses were conducted according to age, sex, and competitive level. Twenty-nine RCTs (n = 450) were included. The network showed moderate heterogeneity and no evidence of significant inconsistency. Combined training (CBT) was ranked highest in effect estimates in CMJ performance compared with traditional soccer training (TST) (MD = 4.92, 95% CI: 3.02-6.83, P-score = 0.98), followed by flywheel resistance training (FT) and plyometric training (PT), whereas other interventions did not demonstrate significant improvements. Subgroup analyses indicated that CBT ranked highest in males, youth, and Tier 2 players; PT ranked highest in females and adults; and FT ranked highest in highly trained players. Given the limited sample sizes, limited statistical power, and the fragmented nature of some subgroup comparisons, these findings should be interpreted cautiously. The network showed moderate heterogeneity (I(2) = 32.4%) and no evidence of significant inconsistency. The certainty of evidence was generally low to moderate according to the CINeMA assessment. Directness of evidence was generally high across comparisons, although several key contrasts (e.g., CBT vs FT and FT vs PT) relied partly on indirect evidence within the network. Although the highest-ranked interventions (CBT, FT, and PT) were supported primarily by direct comparisons with TST, several active-active contrasts relied partly on indirect estimates. The reliability of the intervention rankings depends on similarity in participant characteristics, intervention dose, outcome measurement, and control conditions. CI - (c) Journal of Sports Science and Medicine. FAU - Dong, Xusong AU - Dong X AD - School of Strength and Conditioning Training, Beijing Sport University, Beijing, China. FAU - Li, Tao AU - Li T AD - School of Chinese Basketball, Beijing Sport University, Beijing, China. FAU - Xing, Weihuan AU - Xing W AD - School of Strength and Conditioning Training, Beijing Sport University, Beijing, China. FAU - Chen, Zezhao AU - Chen Z AD - School of Strength and Conditioning Training, Beijing Sport University, Beijing, China. LA - eng PT - Comparative Study PT - Journal Article PT - Network Meta-Analysis PT - Systematic Review DEP - 20260901 PL - Turkey TA - J Sports Sci Med JT - Journal of sports science & medicine JID - 101174629 SB - IM MH - Humans MH - *Soccer/physiology MH - *Athletic Performance/physiology MH - *Plyometric Exercise MH - Resistance Training/methods MH - Randomized Controlled Trials as Topic MH - *Physical Conditioning, Human/methods PMC - PMC13552851 OTO - NOTNLM OT - Soccer OT - countermovement jump OT - explosive performance OT - network meta-analysis OT - training modalities EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 PMCR- 2026/09/01 CRDT- 2026/09/09 07:32 PHST- 2026/04/24 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 07:32 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - 10.52082/jssm.2026.701 [doi] PST - epublish SO - J Sports Sci Med. 2026 Sep 1;25(3):701-713. doi: 10.52082/jssm.2026.701. eCollection 2026 Sep. PMID- 42712825 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260909 LR - 20260910 IS - 0971-4502 (Print) IS - 0974-0449 (Electronic) IS - 0971-4502 (Linking) VI - 42 IP - 5 DP - 2026 Sep TI - Preharvest Platelet Counts Predict Response To Plerixafor in Pediatric Patients Undergoing Autologous Stem Cell Transplant. PG - 1653-1658 LID - 10.1007/s12288-025-02285-4 [doi] AB - Autologous stem cell transplantation (ASCT) following high dose chemotherapy is used for management of various pediatric malignancies, and plerixafor used in conjunction with GCSF is used to mobilize hematopoietic stem cells (HSCs) from bone marrow to peripheral blood for collection. While the efficacy and safety of plerixafor is established in adults, data for its use in children are limited. Factors influencing plerixafor response in pediatric patients have not been extensively investigated. This retrospective study aimed to identify predictors of response to plerixafor in pediatric patients undergoing ASCT. This single-center, retrospective study evaluated 22 pediatric patients who underwent mobilization with granulocyte colony-stimulating factor (GCSF) and plerixafor for ASCT between 2017 and 2024. Patient factors such as age, sex, baseline platelet count, marrow involvement, comorbidities, and malnutrition were recorded. Baseline platelet counts were measured on Day - 1 (the day prior to plerixafor administration). Treatment factors, including exposure to radiotherapy, anthracyclines, and multiple lines of chemotherapy, were also considered. CD34 + cell counts were measured before plerixafor administration and after harvest, and response was assessed by percentage, absolute, and log percent increase in CD34 counts. Regression analysis was done to look at the effect of various factors on response to plerixafor. The study found a significant increase in CD34 counts after plerixafor administration, with a median log percent increase of 3.54 (3.24-3.61). While age and malnutrition showed a significant correlation with log percent CD34 increase (p = 0.012 and p = 0.021, respectively), multivariate regression analysis revealed that only baseline platelet count achieved statistical significance as a predictor of response to plerixafor (p = 0.046). Pre-harvest baseline platelet count is an independent predictor of response to plerixafor in pediatric patients undergoing autologous stem cell transplantation. This finding suggests that baseline platelet counts can help predict the effectiveness of plerixafor-mediated stem cell mobilization in this patient population. Further larger prospective studies are warranted to validate these findings and identify additional factors influencing plerixafor response in pediatric patients. CI - (c) Indian Society of Hematology and Blood Transfusion 2025. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. FAU - Batra, Satyendra AU - Batra S AD - Division of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110001 India. ROR: https://ror.org/02dwcqs71. GRID: grid.413618.9. ISNI: 0000 0004 1767 6103 FAU - Gupta, Aditya Kumar AU - Gupta AK AUID- ORCID: 0000-0002-3730-8944 AD - Division of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110001 India. ROR: https://ror.org/02dwcqs71. GRID: grid.413618.9. ISNI: 0000 0004 1767 6103 FAU - Meena, Jagdish Prasad AU - Meena JP AD - Division of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110001 India. ROR: https://ror.org/02dwcqs71. GRID: grid.413618.9. ISNI: 0000 0004 1767 6103 FAU - Seth, Rachna AU - Seth R AD - Division of Pediatric Oncology, Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, 110001 India. ROR: https://ror.org/02dwcqs71. GRID: grid.413618.9. ISNI: 0000 0004 1767 6103 LA - eng PT - Journal Article DEP - 20251224 PL - India TA - Indian J Hematol Blood Transfus JT - Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion JID - 9425818 PMC - PMC13550363 OTO - NOTNLM OT - Autologous hematopoietic stem cell transplant OT - Mobilization OT - Pediatric OT - Plerixafor COIS- Conflict of interestNone to declare by any author. EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 PMCR- 2027/09/01 CRDT- 2026/09/09 06:43 PHST- 2025/08/15 00:00 [received] PHST- 2025/12/18 00:00 [accepted] PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 06:43 [entrez] PHST- 2027/09/01 00:00 [pmc-release] AID - 2285 [pii] AID - 10.1007/s12288-025-02285-4 [doi] PST - ppublish SO - Indian J Hematol Blood Transfus. 2026 Sep;42(5):1653-1658. doi: 10.1007/s12288-025-02285-4. Epub 2025 Dec 24. PMID- 42712511 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260909 LR - 20260910 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Developing a prediction model of neonatal pneumonia in patients with gestational diabetes mellitus in primary medical institutions. PG - 1840176 LID - 10.3389/fped.2026.1840176 [doi] LID - 1840176 AB - BACKGROUND: The incidence of gestational diabetes mellitus (GDM) continues to rise in China, and the risk of neonatal pneumonia is significantly increased, but the primary medical institutions lack simple and effective early risk assessment methods. OBJECTIVE: To construct a prediction model for neonatal pneumonia suitable for primary medical institutions, based on readily available clinical characteristics of pregnant women with GDM, we aimed to identify key risk factors and provide a basis for developing clinical intervention strategies. METHODS: Data on pregnant women and their newborns at Anyue Maternal and Child Health Hospital from 2023 to 2025 were retrospectively collected. Eight machine learning methods were used to construct the prediction model by bootstrap method and SHapley Additive exPlanations (SHAP) was used to enhance the model's interpretability. RESULTS: A total of 328 pairs of mothers and newborns were included, and the incidence of neonatal pneumonia was 8.8%. Among the eight prediction models, Random Forest model performed the best and Decision tree model was the worst; SHAP results indicated education level, BMI, hyperemesis gravidarum, primipara, hyperlipidemia during pregnancy, premature birth and job were most influencing factors. Binary logistic regression analysis showed that premature birth (OR = 4.763, 95% CI = 1.522-14.901, P = 0.007), Hyperemesis Gravidarum (OR = 3.706, 95% CI = 1.587-8.653, P = 0.002), and cesarean section (OR = 2.456, 95% CI = 1.050-5.745, P = 0.038) were risk factor of neonatal pneumonia, with a protective factor of higher education level (OR = 0.370, 95% CI = 0.158-0.865, P = 0.022). CONCLUSION: Despite the limited number of neonatal pneumonia events, our findings provide preliminary evidence that it may be feasible to develop a simplified risk-stratification tool for neonatal pneumonia in pregnancies complicated by GDM using routinely available clinical variables. Further multicentre prospective studies are required to determine the optimal predictor set and externally validate the model before clinical application. CI - (c) 2026 Wu, Cao, Wu, Liao, Li and Yang. FAU - Wu, Lian AU - Wu L AD - Department of Pediatrics and Obstetrics, Anyue Maternal and Child Health Hospital, Ziyang, Sichuan, China. FAU - Cao, Qun AU - Cao Q AD - Department of Pediatrics and Obstetrics, Anyue Maternal and Child Health Hospital, Ziyang, Sichuan, China. FAU - Wu, Jing AU - Wu J AD - Department of Pediatrics and Obstetrics, Anyue Maternal and Child Health Hospital, Ziyang, Sichuan, China. FAU - Liao, Ting AU - Liao T AD - Department of Pediatrics and Obstetrics, Anyue Maternal and Child Health Hospital, Ziyang, Sichuan, China. FAU - Li, Li AU - Li L AD - Department of Pediatrics and Obstetrics, Anyue Maternal and Child Health Hospital, Ziyang, Sichuan, China. FAU - Yang, Chengying AU - Yang C AD - Department of Pediatrics and Obstetrics, Anyue Maternal and Child Health Hospital, Ziyang, Sichuan, China. LA - eng PT - Journal Article DEP - 20260825 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13550188 OTO - NOTNLM OT - gestational diabetes mellitus OT - hyperemesis during pregnancy OT - neonatal pneumonia OT - prediction model OT - preterm COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 PMCR- 2026/08/25 CRDT- 2026/09/09 06:08 PHST- 2026/03/27 00:00 [received] PHST- 2026/08/12 00:00 [revised] PHST- 2026/08/12 00:00 [accepted] PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 06:08 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.3389/fped.2026.1840176 [doi] PST - epublish SO - Front Pediatr. 2026 Aug 25;14:1840176. doi: 10.3389/fped.2026.1840176. eCollection 2026. PMID- 42712495 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260909 LR - 20260910 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Four laparoscopic surgical strategies for pediatric direct inguinal hernia: a retrospective single-center case series of six male children. PG - 1916132 LID - 10.3389/fped.2026.1916132 [doi] LID - 1916132 AB - OBJECTIVE: Pediatric direct inguinal hernia is a rare subtype of inguinal hernia, characterized by protrusion of abdominal viscera through the weak posterior wall of the inguinal canal without passing through the internal inguinal ring. This condition results from congenital hypoplasia of the transversalis fascia and focal structural defects in the inguinal region, with a lower incidence than pediatric indirect inguinal hernia. Multiple laparoscopic protocols for pediatric direct inguinal hernia have been reported, yet no unified surgical standard has been established, and relevant clinical data lack systematic collation. This retrospective single-center case series summarizes clinical experience of four laparoscopic repair techniques for pediatric direct inguinal hernia, with emphasis on surgical procedures, postoperative complications and long-term hernia recurrence. This study aims to report clinical outcomes of the four laparoscopic approaches and clarify the selection strategy of the four surgical modalities. METHODS: This is a retrospective, single-center, formal consecutive clinical case series. Inclusion criteria: 1) were intraoperatively confirmed as having primary direct inguinal hernia during laparoscopic surgery; 2) had complete electronic medical records, operative notes and outpatient follow-up data; 3) received laparoscopic repair techniques. Exclusion criteria: 1) combined indirect inguinal hernia, femoral hernia or other complicated inguinal region abnormalities; 2) recurrent hernia after prior inguinal surgery; 3) incomplete clinical or follow-up data. All patients underwent laparoscopic direct inguinal hernia repair at Shengli Oilfield Central Hospital between January 2019 and April 2026. Clinical data including age, gender, operation date, surgical technique and complications were retrospectively reviewed and analyzed. RESULTS: Six male pediatric patients met the inclusion criteria, and none satisfied any exclusion criterion. Among them, five presented with unilateral hernia and one with bilateral hernia. The median age was 3 years and 9 months (range: 2 years and 1 month to 7 years and 3 months). All children were preoperatively suspected to have indirect inguinal hernia by physical examination, while direct inguinal hernia was confirmed intraoperatively. All patients received laparoscopic repair adopting four distinct surgical techniques: laparoscopic eversion and lateral fixation of direct hernia sac, laparoscopic high ligation of direct hernia sac, laparoscopic reinforcement with medial umbilical ligament, and combined laparoscopic high ligation of hernia sac plus medial umbilical ligament reinforcement. All operations were completed successfully with minimal intraoperative blood loss. No intraoperative injuries to the vas deferens, spermatic vessels, testis, bowel, urinary bladder, external iliac vessels or nerves were identified. Oral liquid diet was resumed 6 to 8 h after surgery, and daily activities were restored within 24 h postoperatively. No short-term complications such as surgical site infection or hematoma occurred in any patient. The final follow-up was conducted in June 2026 before manuscript submission, with follow-up durations ranging from 5 months to 82 months. No long-term complications including hernia recurrence, testicular atrophy or chronic inguinal pain were documented in all subjects. CONCLUSION: Laparoscopic surgery is safe, reliable and minimally invasive for pediatric direct inguinal hernia. Based on our single-center experience, surgical selection depends on whether the hernia sac is amenable to ligation and whether the medial umbilical ligament can sufficiently cover the Hesselbach's triangle. Large-cohort studies are required to further validate the clinical efficacy of each repair strategy. CI - (c) 2026 Xu, Han, Ding, Zhang, Liu, Jiang and Shi. FAU - Xu, Yan AU - Xu Y AD - Department of Pediatric Surgery, Shengli Oilfield Central Hospital, Dongying, China. FAU - Han, Shuaishuai AU - Han S AD - Department of Pediatric Surgery, Shengli Oilfield Central Hospital, Dongying, China. FAU - Ding, Haixin AU - Ding H AD - Department of Pediatric Surgery, Shengli Oilfield Central Hospital, Dongying, China. FAU - Zhang, Fenghui AU - Zhang F AD - Department of Pediatric Surgery, Shengli Oilfield Central Hospital, Dongying, China. FAU - Liu, Siyu AU - Liu S AD - Department of Medical Records Management, Shengli Oilfield Central Hospital, Dongying, China. FAU - Jiang, Wenxin AU - Jiang W AD - Department of Pediatrics, Shengli Oilfield Central Hospital, Dongying, China. FAU - Shi, Jizhou AU - Shi J AD - Department of Pediatric Surgery, Shengli Oilfield Central Hospital, Dongying, China. AD - Department of Pediatric Surgery, Dongying District People's Hospital, Dongying, China. LA - eng PT - Journal Article DEP - 20260825 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13550138 OTO - NOTNLM OT - case series OT - hernia sac eversion OT - hernia sac ligation OT - hesselbach's triangle OT - laparoscopic hernia repair OT - pediatric direct inguinal hernia COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 PMCR- 2026/08/25 CRDT- 2026/09/09 06:04 PHST- 2026/06/22 00:00 [received] PHST- 2026/08/02 00:00 [revised] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 06:04 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.3389/fped.2026.1916132 [doi] PST - epublish SO - Front Pediatr. 2026 Aug 25;14:1916132. doi: 10.3389/fped.2026.1916132. eCollection 2026. PMID- 42712217 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260914 IS - 1471-2865 (Electronic) IS - 1358-2267 (Print) IS - 1358-2267 (Linking) VI - 31 IP - 4 DP - 2026 Oct TI - Criterion Validity of the 30-Second Chair Stand Test for Lower-Limb Muscle Strength in Adults With Severe Mental Disorders: The PsychiActive Project. PG - e70344 LID - 10.1002/pri.70344 [doi] LID - e70344 AB - BACKGROUND AND PURPOSE: Individuals with Severe Mental Disorders (SMDs) face a high risk of premature mortality and disability due to accelerated neuromuscular decline. Despite the critical need to monitor physical function, the lack of validated, time-efficient tools limits their clinical utility and hinders the integration of objective assessments into routine care. This gap limits the early identification of physical function impairments and the implementation of timely evidence-based interventions. This is the first study to evaluate the criterion validity of the 30-s Chair Stand Test (30s-CST) as a pragmatic indicator of lower-limb muscle strength in adults with SMDs, providing a feasible functional indicator to support routine clinical assessment. METHODS: Using a cross-sectional validation design (STROBE), this study was conducted with 91 adults (18-65 years) diagnosed with SMDs. Participants performed the 30s-CST and reference isometric Knee Extension Strength (KES) testing. Statistical analyses included Pearson's correlation (r), Intraclass Correlation Coefficients (ICC), and Bland-Altman plots to determine agreement and heteroscedasticity, with sub-analyses by sex, age, and body mass index. RESULTS: Analysis revealed significant moderate correlation and agreement (r = 0.56 [95% CI 0.40-0.69]; ICC = 0.54 [0.38-0.67]; both p < 0.001) for the total sample, with stronger results in the female subgroup. The 30s-CST demonstrated precision, with a prediction error lower than the within-subject variability of the reference method. Bland-Altman plots showed acceptable agreement, with narrow limits of agreement (-1.79-1.80), and analysis indicated homoscedasticity. DISCUSSION: The 30s-CST appears to be a pragmatic and time-efficient screening tool for identifying individuals with reduced lower-limb muscle strength in SMDs. Although limited by the lack of biomechanical specificity between dynamic and isometric methods, the test offers a balance between clinical feasibility and its ability to provide a functional estimate related to lower-limb muscle strength. Integrating this pragmatic screening tool into routine practice may support the assessment of functional performance in resource-constrained settings where more complex strength assessments are not readily available. CI - (c) 2026 The Author(s). Physiotherapy Research International published by John Wiley & Sons Ltd. FAU - Lopez-Moral, Alvaro AU - Lopez-Moral A AUID- ORCID: 0000-0003-0862-8655 AD - Physical Performance & Sports Research Center (CIRFD), Department of Sports and Computer Science, Section of Physical Education and Sports, Faculty of Sports Sciences, Universidad Pablo de Olavide, Seville, Spain. AD - Department of Physical Education and Sport, Universidad de Sevilla, Seville, Spain. FAU - Munguia-Izquierdo, Diego AU - Munguia-Izquierdo D AUID- ORCID: 0000-0001-7817-747X AD - Physical Performance & Sports Research Center (CIRFD), Department of Sports and Computer Science, Section of Physical Education and Sports, Faculty of Sports Sciences, Universidad Pablo de Olavide, Seville, Spain. AD - Research Group in Development Movimiento Humano, Universidad de Zaragoza, Zaragoza, Spain. FAU - Bueno-Antequera, Javier AU - Bueno-Antequera J AUID- ORCID: 0000-0001-8063-3980 AD - Physical Performance & Sports Research Center (CIRFD), Department of Sports and Computer Science, Section of Physical Education and Sports, Faculty of Sports Sciences, Universidad Pablo de Olavide, Seville, Spain. AD - Research Group in Development Movimiento Humano, Universidad de Zaragoza, Zaragoza, Spain. LA - eng GR - PID2020-118262RB-I00/Ministerio de Ciencia e Innovacion/ GR - POSTDOC_21_00059/Consejeria de Transformacion Economica, Industria, Conocimiento y Universidades/ GR - PPI1803/Universidad Pablo de Olavide/ PT - Journal Article PT - Validation Study PL - United States TA - Physiother Res Int JT - Physiotherapy research international : the journal for researchers and clinicians in physical therapy JID - 9612022 SB - IM MH - Humans MH - Female MH - *Muscle Strength/physiology MH - Adult MH - Middle Aged MH - Cross-Sectional Studies MH - Male MH - Reproducibility of Results MH - *Lower Extremity/physiopathology MH - *Mental Disorders/physiopathology MH - Aged MH - Young Adult MH - Adolescent PMC - PMC13555177 OTO - NOTNLM OT - chair stand test OT - functional assessment OT - muscle strength OT - physical function OT - physical performance OT - rehabilitation OT - severe mental disorders COIS- The authors declare no conflicts of interest. EDAT- 2026/09/09 11:38 MHDA- 2026/09/09 11:39 PMCR- 2026/09/09 CRDT- 2026/09/09 05:32 PHST- 2026/08/05 00:00 [revised] PHST- 2026/03/04 00:00 [received] PHST- 2026/08/11 00:00 [accepted] PHST- 2026/09/09 11:39 [medline] PHST- 2026/09/09 11:38 [pubmed] PHST- 2026/09/09 05:32 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - PRI70344 [pii] AID - 10.1002/pri.70344 [doi] PST - ppublish SO - Physiother Res Int. 2026 Oct;31(4):e70344. doi: 10.1002/pri.70344. PMID- 42711707 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260921 IS - 1741-7015 (Electronic) IS - 1741-7015 (Linking) VI - 24 IP - 1 DP - 2026 Aug 27 TI - Conflicting evidence for continuous glucose monitoring in gestational diabetes: current challenges and the imperative for individual participant data meta-analysis. LID - 10.1186/s12916-026-05191-2 [doi] LID - 476 AB - BACKGROUND: The incidence of gestational diabetes mellitus (GDM) is rising along with rates of obesity and type 2 diabetes. GDM is associated with an increased risk of various short- and long-term complications for both mother and child, including type 2 diabetes. Managing GDM requires a multidisciplinary approach that includes dietary guidance, promoting regular physical activity, and performing self-monitoring of blood glucose (SMBG). Continuous glucose monitoring (CGM) has transformed pregnancy care in women with type 1 diabetes and is increasingly being proposed as a strategy to improve glycaemic management in GDM. By capturing postprandial glucose excursions, glycaemic variability, and time in range, CGM provides a more detailed picture of glycaemia and has raised expectations of improved metabolic control and pregnancy outcomes. MAIN BODY: Despite these theoretical advantages, evidence for CGM in GDM remains conflicting. More recently, several large randomized controlled trials (RCT's) show conflicting data: some studies show modest improvements in glycaemic measures, whereas others report no clear benefit for key maternal or neonatal outcomes, leaving the clinical value and cost-effectiveness of CGM unclear. A major limitation is the absence of validated CGM-based glycaemic targets specific to GDM, and current guidelines offer little direction beyond conventional SMBG guidelines. Future research should prioritize adequately powered large RCT's representing a broad population, and, importantly, individual participant data meta-analyses to reconcile inconsistent findings, identify subgroups most likely to benefit, establish pregnancy-specific CGM thresholds, and evaluate the impact on both obstetric outcomes and long-term postpartum metabolic risk. CONCLUSIONS: This ongoing debate underscores the need to critically appraise the role of CGM in GDM, summarize results from completed RCT's and meta-analyses, recognize key methodological and clinical evidence gaps, and outline the steps required for CGM to become fully integrated into standard GDM care. CI - (c) 2026. The Author(s). FAU - Geerts, Ina AU - Geerts I AD - Clinical and Experimental Endocrinology, KU Leuven, 3000, Leuven, Belgium. FAU - Yu, Catherine AU - Yu C AD - Clinical and Experimental Endocrinology, KU Leuven, 3000, Leuven, Belgium. FAU - Embo, Nina AU - Embo N AD - Clinical and Experimental Endocrinology, KU Leuven, 3000, Leuven, Belgium. FAU - Benhalima, Katrien AU - Benhalima K AUID- ORCID: 0000-0002-3325-0263 AD - Clinical and Experimental Endocrinology, KU Leuven, 3000, Leuven, Belgium. katrien.benhalima@uzleuven.be. AD - Department of Endocrinology, University Hospitals Leuven, 3000, Leuven, Belgium. katrien.benhalima@uzleuven.be. LA - eng PT - Journal Article PT - Review DEP - 20260827 PL - England TA - BMC Med JT - BMC medicine JID - 101190723 RN - 0 (Blood Glucose) SB - IM MH - Female MH - Humans MH - Pregnancy MH - *Blood Glucose/analysis MH - *Blood Glucose Self-Monitoring/methods MH - *Continuous Glucose Monitoring MH - *Diabetes, Gestational/blood/diagnosis/therapy MH - Meta-Analysis as Topic PMC - PMC13556021 OTO - NOTNLM OT - Continuous glucose monitoring OT - Gestational diabetes mellitus OT - Individual participant data meta-analysis OT - Pregnancy OT - Technology COIS- Declarations. Ethics approval and consent to participate: not applicable. Consent for publication: not applicable. AI statement: Microsoft Copilot was used solely for language editing to improve the clarity and readability of the manuscript. The authors reviewed and edited all AI-assisted text and take full responsibility for the content of the manuscript. Competing interests: I.G. is the recipient of a PhD fellowship, strategic basic research (FWO-SB) from the Flemish Research Council (FWO) 1S82826N. KB received a senior clinical fellowship from FWO Flanders (1800220 N). KB received an unrestricted grant and study devices from Medtronic for the investigator-initiated CRISTAL study. KB received study devices from Dexcom for the investigator-initiated GLORIA study. KB received study medication from Novo Nordisk A/S for the investigator-initiated SERENA study. KB received study devices from Abbott and LifeScan, and a grant from Abbott for the investigator-initiated CORDELIA study. KB received a speaker's fee from Novo Nordisk, AstraZeneca, and Medtronic. KB was a Guest Editor for the Diagnosis and Management of Gestational Diabetes collection (special issue on gestational diabetes). All other authors declared no competing interests. EDAT- 2026/09/09 07:07 MHDA- 2026/09/09 11:38 PMCR- 2026/08/27 CRDT- 2026/09/09 04:50 PHST- 2026/05/26 00:00 [received] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/09/09 11:38 [medline] PHST- 2026/09/09 07:07 [pubmed] PHST- 2026/09/09 04:50 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - 10.1186/s12916-026-05191-2 [pii] AID - 5191 [pii] AID - 10.1186/s12916-026-05191-2 [doi] PST - epublish SO - BMC Med. 2026 Aug 27;24(1):476. doi: 10.1186/s12916-026-05191-2. PMID- 42711563 OWN - NLM STAT- Publisher LR - 20260909 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Sep 8 TI - Comparing two diagnostic frameworks for obesity in Mexican children attending a pediatric obesity clinic. LID - 10.1038/s41390-026-05479-2 [doi] AB - BACKGROUND: Body mass index (BMI) is widely used to assess pediatric obesity but does not fully capture adiposity-related organ dysfunction. The Clinical Framework of Obesity 2025 (CFO-2025), proposed by The Lancet Diabetes & Endocrinology Commission, offers a complementary clinical approach. OBJECTIVE: To evaluate pediatric obesity classification using Centers for Disease Control and Prevention BMI (CDC-BMI) criteria and the CFO-2025, and to describe organ-system involvement in clinical obesity. METHODS: This cross-sectional study analyzed 220 patients aged 4-16 years from a pediatric obesity clinic in northeastern Mexico. Obesity was classified using CDC-BMI criteria and the CFO-2025 with pediatric adaptations. Under the CFO-2025, patients were categorized as having preclinical or clinical obesity based on organ-system involvement. Concordance was assessed using Cohen's kappa. RESULTS: Obesity prevalence was 80% by CDC-BMI criteria and 95% by the CFO-2025, with fair concordance (kappa = 0.321; p < 0.001). Clinical obesity was identified in 83.2% of patients, including those classified as having normal weight or overweight by CDC-BMI; metabolic (73.2%) and cardiovascular (59%) systems were most frequently affected. CONCLUSIONS: Applied alongside BMI, the CFO-2025 identified additional multisystem involvement. Although not yet validated in children, it may support a more comprehensive clinical assessment of pediatric obesity. IMPACT: In the Pediatric Obesity Clinic at a referral hospital in northeastern Mexico, the Clinical Framework of Obesity 2025 (CFO-2025) classified a higher proportion of children as having obesity compared with the CDC-BMI criteria, with only fair concordance between systems. We provide preliminary pediatric evidence that the CFO-2025 identifies multisystem involvement, including metabolic and cardiovascular abnormalities, even among children categorized as normal weight or overweight by BMI. Although the CFO-2025 has not yet been validated in pediatric populations, integrating BMI with the CFO-2025 may support a more structured and comprehensive assessment of obesity-related organ involvement in children. CI - (c) 2026. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Guzman-Garcia, Judith E AU - Guzman-Garcia JE AD - Pediatric Obesity Clinic, Hospital Regional Materno Infantil, Guadalupe, Mexico. drajudithguzman@gmail.com. AD - Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Mexico. drajudithguzman@gmail.com. FAU - Gomez-Orozco, Patricio AU - Gomez-Orozco P AD - Pediatric Obesity Clinic, Hospital Regional Materno Infantil, Guadalupe, Mexico. AD - Universidad Autonoma de Nuevo Leon, School of Medicine, Monterrey, Mexico. FAU - Velasco-Rodriguez, Victor Manuel AU - Velasco-Rodriguez VM AD - Universidad Autonoma de Coahuila, Faculty of Nursing, Laguna Unit, Torreon, Mexico. FAU - Martinez-Tapia, Maria Elena AU - Martinez-Tapia ME AD - Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Mexico. FAU - Rodriguez-Gutierrez, Nora A AU - Rodriguez-Gutierrez NA AUID- ORCID: 0009-0003-0302-7145 AD - Pediatric Obesity Clinic, Hospital Regional Materno Infantil, Guadalupe, Mexico. AD - Tecnologico de Monterrey, School of Medicine and Health Sciences, Monterrey, Mexico. LA - eng PT - Journal Article DEP - 20260908 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Consent statement: The requirement for individual informed consent was waived by the Ethics Committee of the Hospital Regional Materno Infantil and the Department of Education, Health Research, and Quality of the Ministry of Health of Nuevo Leon due to the retrospective design of the study and the use of de-identified data. EDAT- 2026/09/09 07:07 MHDA- 2026/09/09 07:07 CRDT- 2026/09/09 04:27 PHST- 2026/02/24 00:00 [received] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/06/26 00:00 [revised] PHST- 2026/09/09 07:07 [medline] PHST- 2026/09/09 07:07 [pubmed] PHST- 2026/09/09 04:27 [entrez] AID - 10.1038/s41390-026-05479-2 [pii] AID - 10.1038/s41390-026-05479-2 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Sep 8. doi: 10.1038/s41390-026-05479-2. PMID- 42711085 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260912 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 9 DP - 2026 Sep 8 TI - School- and home-based hybrid exercise intervention to prevent summer fitness loss in children: protocol for a feasibility study of the keep moving in a structured summer programme. PG - e123307 LID - 10.1136/bmjopen-2026-123307 [doi] LID - e123307 AB - INTRODUCTION: Schools are key settings to intervene for the purpose of health promotion in children. However, the effectiveness of school-based interventions remains limited, potentially related to the obesogenic behaviours observed during holidays as posited by the structured days hypothesis. This study aims to evaluate the feasibility, process evaluation and preliminary efficacy of the keep moving in a structured summer (KEMOSS) intervention among Chinese children. METHODS AND ANALYSIS: The KEMOSS intervention is an 8-week hybrid programme comprising two digitally supported home-based phases (weeks 1-2 and 7-8) and a structured school-based phase (weeks 3-6). The school-based phase will be a full-day scheduled programme that replicates the routine of regular school days, with a coach-led structured physical activity lesson and a free-play lesson embedded in the morning and afternoon, respectively. During the home-based phases, participants will be encouraged to complete prescribed exercises independently with support from mHealth reminders and instructional materials and to achieve a minimum of 10 000 steps per day. Feasibility, process evaluation and preliminary efficacy outcomes will be assessed using a mixed-methods approach. Quantitative data will be analysed using SPSS, while qualitative data from interviews and focus groups will be analysed thematically using NVivo. ETHICS AND DISSEMINATION: Ethical approval has been obtained from the Ningbo University Ethics Committee (TY2026028). Findings will inform the refinement of the intervention and the design of a future definitive trial. Results will be disseminated through peer-reviewed publications and conference presentations. TRIAL REGISTRATION NUMBER: ChiCTR2600126738. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Liu, Yong AU - Liu Y AUID- ORCID: 0009-0008-3649-5064 AD - Department of Sports and Arts, Zhejiang Wanli University, Ningbo, Zhejiang, China. FAU - Gu, Jiayi AU - Gu J AD - Faculty of Sports Science, Ningbo University, Ningbo, Zhejiang, China. FAU - Li, Minghui AU - Li M AD - Faculty of Sports Science, Ningbo University, Ningbo, Zhejiang, China. FAU - Guo, Qiang AU - Guo Q AD - Faculty of Sports Science, Ningbo University, Ningbo, Zhejiang, China. FAU - Geng, Renshang AU - Geng R AD - Faculty of Sports Science, Ningbo University, Ningbo, Zhejiang, China. FAU - Dai, Lulin AU - Dai L AD - Faculty of Sports Science, Ningbo University, Ningbo, Zhejiang, China. FAU - Xiao, Peizhen AU - Xiao P AD - Faculty of Sports Science, Ningbo University, Ningbo, Zhejiang, China. FAU - Zheng, Yuanyuan AU - Zheng Y AD - Faculty of Sports Science, Ningbo University, Ningbo, Zhejiang, China. FAU - Sun, Fucheng AU - Sun F AUID- ORCID: 0009-0003-5539-721X AD - Department of Physical Education, Nanjing Agricultural University, Nanjing, Jiangsu, China fucheng.sun@hotmail.com. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260908 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Feasibility Studies MH - Seasons MH - Clinical Trials as Topic MH - *Physical Fitness MH - *Program Evaluation MH - *School Health Services MH - Humans MH - Child MH - *Exercise Therapy/methods MH - Research Design MH - Play and Playthings MH - *Telemedicine MH - Exercise MH - China PMC - PMC13560971 OTO - NOTNLM OT - Child OT - Feasibility Studies OT - Physical Fitness OT - Randomized Controlled Trial OT - Schools COIS- Competing interests: None declared. EDAT- 2026/09/08 23:35 MHDA- 2026/09/08 23:36 PMCR- 2026/09/08 CRDT- 2026/09/08 21:03 PHST- 2026/09/08 23:36 [medline] PHST- 2026/09/08 23:35 [pubmed] PHST- 2026/09/08 21:03 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - bmjopen-2026-123307 [pii] AID - 10.1136/bmjopen-2026-123307 [doi] PST - epublish SO - BMJ Open. 2026 Sep 8;16(9):e123307. doi: 10.1136/bmjopen-2026-123307. PMID- 42711081 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260912 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 9 DP - 2026 Sep 8 TI - AllPlay Dance autism: protocol for a randomised controlled trial of a community-based dance programme for children with autism. PG - e122285 LID - 10.1136/bmjopen-2026-122285 [doi] LID - e122285 AB - INTRODUCTION: Motor skills are integral to numerous developmental domains throughout infancy and childhood. In autism, motor impairments are prevalent and pervasive, often appearing before core symptoms. These motor difficulties have a cascading effect on a child's broader physical and psychological health, including social, cognitive, emotional and behavioural functioning. Accordingly, researchers are increasingly interested in interventions that improve motor functioning, as these may have a downstream effect on broader developmental domains. One intervention that could address motor difficulties is the AllPlay Dance programme, which provides inclusive dance classes to children in community settings, with pilot data demonstrating acceptability and feasibility among parents and their children with autism and cerebral palsy. This pragmatic randomised controlled trial (pRCT) is thus designed to evaluate whether the AllPlay Dance programme creates the conditions for motor, cognitive and social abilities to thrive in children with autism. METHOD AND ANALYSIS: This pRCT intends to enrol 70 families of children with autism, aged 7-12 years, living in Victoria, Australia. We will also enrol up to 60 participants with previous dance experience, called buddies, to support the participation of our dancers with autism. We will use our clinical, research, university and community networks to recruit participants. Interested families will complete an online screening survey, followed by questionnaires that parents complete and assessments of the motor functioning in the children. Interested buddies will also complete an online screening survey followed by a baseline questionnaire. Families will be randomly allocated to the intervention group or the treatment-as-usual waitlist control group. The intervention group will attend 9 weeks of community-based dance classes led by disability and dance experts and supported by buddies. The primary outcome is change in motor functioning, as assessed through performance-based measures, with parent reports providing complementary information about everyday motor functioning. Secondary outcomes include improvements in the executive, social, emotional and behavioural functioning of the children, as well as decreases in the stress of parents. We will also evaluate the acceptability and feasibility of this programme, as well as whether families decide to enrol and engage with other dance programmes in the community following the intervention. ETHICS AND DISSEMINATION: The study has received approval from the Monash University Human Research Ethics Committee and the Deakin University Human Research Ethics Committee. Findings will be disseminated through a PhD thesis, peer-reviewed publications, presentations at scientific conferences and reports to participants, community organisations and the wider community. TRIAL REGISTRATION NUMBER: Australian New Zealand Clinical Trials Registry (ANZCTR); ACTRN12625000600448; registered on 11 June 2025; https://anzctr.org.au/Trial/Registration/TrialReview.aspx?id=389672. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Chadha, Mehak AU - Chadha M AUID- ORCID: 0009-0005-3306-3491 AD - Monash University, Melbourne, Victoria, Australia mehak.chadha@monash.edu. FAU - Lindor, Ebony AU - Lindor E AD - Monash University, Melbourne, Victoria, Australia. FAU - Millard, Olivia AU - Millard O AD - Deakin University, Melbourne, Victoria, Australia. FAU - Moss, Simon AU - Moss S AD - Monash University, Melbourne, Victoria, Australia. FAU - Rinehart, Nicole AU - Rinehart N AD - Monash University, Melbourne, Victoria, Australia. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260908 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Child MH - *Autistic Disorder/therapy/rehabilitation MH - *Dance Therapy/methods MH - *Dancing MH - Randomized Controlled Trials as Topic MH - Male MH - Female MH - Victoria MH - Motor Skills PMC - PMC13561022 OTO - NOTNLM OT - Autistic Disorder OT - Dancing OT - Exercise OT - MENTAL HEALTH OT - Motor Skills OT - Pragmatic Clinical Trial COIS- Competing interests: None declared. EDAT- 2026/09/08 23:35 MHDA- 2026/09/08 23:36 PMCR- 2026/09/08 CRDT- 2026/09/08 21:03 PHST- 2026/09/08 23:36 [medline] PHST- 2026/09/08 23:35 [pubmed] PHST- 2026/09/08 21:03 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - bmjopen-2026-122285 [pii] AID - 10.1136/bmjopen-2026-122285 [doi] PST - epublish SO - BMJ Open. 2026 Sep 8;16(9):e122285. doi: 10.1136/bmjopen-2026-122285. PMID- 42710441 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261013 IS - 1879-1379 (Electronic) IS - 0022-3956 (Linking) VI - 203 DP - 2026 Dec TI - The interplay between interoceptive sensibility and mindfulness in eating behaviors and psychological distress: A person-centered study in a French community sample. PG - 51-59 LID - S0022-3956(26)00427-9 [pii] LID - 10.1016/j.jpsychires.2026.09.001 [doi] AB - This study examined interoception and mindfulness as related processes in eating behaviors in a non-clinical population. The aim was to identify interoceptive sensibility and mindfulness clusters using a person-centered approach and to examine their associations with eating behaviors, eating disorder risk, body mass index, and psychological distress. An online survey was conducted in a French community sample of 381 adults. Participants completed validated self-report measures assessing interoceptive sensibility, mindfulness, eating behaviors, and psychological distress. Cluster analysis identified four distinct groups reflecting different combinations of interoceptive sensibility and mindfulness. Profiles characterized by higher mindfulness consistently showed more adaptive eating patterns, including lower emotional and external eating and greater reliance on internal cues, regardless of interoceptive levels. In contrast, clusters with lower mindfulness showed higher levels of emotional eating and psychological distress. Within these low mindfulness profiles, high interoception was associated with lower depressive symptoms, lower eating disorder risk, and normal-weight status. These findings suggest that mindfulness was consistently associated with adaptive eating and psychological outcomes across profiles, whereas interoceptive sensibility further differentiated outcomes among profiles characterized by lower mindfulness. Overall, the results highlight the importance of considering both interoceptive sensibility and mindfulness jointly to better understand variability in eating behaviors and psychological distress. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Marinelli, L AU - Marinelli L AD - Univ. Bordeaux LabPsy, UR 4139, Bordeaux, F-33000, France; University Hospital Center of Bordeaux, Haut Leveque Hospital, Eating Disorders Unit, Pessac, 33600, France. Electronic address: lea.marinelli@u-bordeaux.fr. FAU - Berthoz, S AU - Berthoz S AD - Univ. Bordeaux, INCIA CNRS 5287, Bordeaux, 33000, France; Department of Psychiatry for Adolescents & Young Adults, Institut Medico-chirurgical (IMM), Paris, 75014, France. Electronic address: sylvie.berthoz-landron@inserm.fr. FAU - Decamps, G AU - Decamps G AD - Univ. Bordeaux LabPsy, UR 4139, Bordeaux, F-33000, France. Electronic address: greg.decamps@u-bordeaux.fr. FAU - Bourdier, L AU - Bourdier L AD - University Hospital Center of Bordeaux, Haut Leveque Hospital, Eating Disorders Unit, Pessac, 33600, France. Electronic address: lena.bourdier@chu-bordeaux.fr. FAU - Fatseas, M AU - Fatseas M AD - University Hospital Center of Bordeaux, Haut Leveque Hospital, Eating Disorders Unit, Pessac, 33600, France; Univ. Bordeaux, INCIA CNRS 5287, Bordeaux, 33000, France; CH Charles Perrens, Bordeaux, 33000, France. Electronic address: melina.fatseas@u-bordeaux.fr. FAU - Dantzer, C AU - Dantzer C AD - Univ. Bordeaux LabPsy, UR 4139, Bordeaux, F-33000, France. Electronic address: cecile.dantzer@u-bordeaux.fr. LA - eng PT - Journal Article DEP - 20260903 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 SB - IM MH - Humans MH - Female MH - *Mindfulness MH - Male MH - Adult MH - *Feeding Behavior/psychology/physiology MH - *Interoception/physiology MH - France MH - Young Adult MH - *Psychological Distress MH - Middle Aged MH - Feeding and Eating Disorders/psychology MH - Cluster Analysis MH - Adolescent MH - *Stress, Psychological/psychology/physiopathology MH - Body Mass Index MH - Emotional Eating OTO - NOTNLM OT - Cluster analysis OT - Eating behavior OT - Interoceptive sensibility OT - Intuitive eating OT - Mindfulness COIS- Declaration of competing interest None. EDAT- 2026/09/08 23:35 MHDA- 2026/10/13 23:35 CRDT- 2026/09/08 18:16 PHST- 2025/02/03 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/09/02 00:00 [accepted] PHST- 2026/10/13 23:35 [medline] PHST- 2026/09/08 23:35 [pubmed] PHST- 2026/09/08 18:16 [entrez] AID - S0022-3956(26)00427-9 [pii] AID - 10.1016/j.jpsychires.2026.09.001 [doi] PST - ppublish SO - J Psychiatr Res. 2026 Dec;203:51-59. doi: 10.1016/j.jpsychires.2026.09.001. Epub 2026 Sep 3. PMID- 42710439 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261013 IS - 1879-1379 (Electronic) IS - 0022-3956 (Linking) VI - 203 DP - 2026 Dec TI - Treating sleep problems in children with Prader-Willi syndrome. PG - 33-40 LID - S0022-3956(26)00422-X [pii] LID - 10.1016/j.jpsychires.2026.08.025 [doi] AB - The purpose of the present study was to investigate the effects of a sleep treatment package on the frequency of night awakenings, bedtime resistance, and caregiver stress with the caregivers of three child participants diagnosed with Prader-Willi syndrome (PWS) using a multiple baseline across subjects design. During baseline, child participants were not exposed to any procedure. During intervention, caregivers implemented a treatment package including graduated extinction, bedtime routines, and bedtime fading without response cost. All interventions were previously successful with children diagnosed with autism spectrum disorder but had not been attempted with this population. Correct responding was defined as zero instances of night awakenings, zero instances of bedtime resistance (different for each child participant) and decreases in caregiver-reported stress. In addition, social validity was assessed using a Likert-style questionnaire. The results show that the treatment package had varying success across all participants, with the most success being for reducing behaviors at bedtime. These results will provide further understanding of the effect behavior-analytic approaches can have on children diagnosed with Prader-Willi syndrome, increasing the number of applications of applied behavior analysis and the supports available for caregivers of children diagnosed with PWS. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Weavers, Aliana AU - Weavers A AD - Brock University, 1812 Sir Isaac Brock Way, St. Catharines, Canada. Electronic address: aweavers@brocku.ca. FAU - Kruse, Laura AU - Kruse L AD - The Chicago School, United States of America. LA - eng PT - Journal Article DEP - 20260904 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 SB - IM MH - Humans MH - *Prader-Willi Syndrome/complications MH - *Sleep Wake Disorders/etiology/therapy MH - Child MH - Male MH - Female MH - Caregivers/psychology MH - *Behavior Therapy/methods MH - Surveys and Questionnaires MH - Treatment Outcome OTO - NOTNLM OT - Applied behaviour analysis OT - Children OT - Prader-willi syndrome OT - Sleep COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/08 23:35 MHDA- 2026/10/13 23:35 CRDT- 2026/09/08 18:16 PHST- 2026/02/06 00:00 [received] PHST- 2026/08/07 00:00 [revised] PHST- 2026/08/27 00:00 [accepted] PHST- 2026/10/13 23:35 [medline] PHST- 2026/09/08 23:35 [pubmed] PHST- 2026/09/08 18:16 [entrez] AID - S0022-3956(26)00422-X [pii] AID - 10.1016/j.jpsychires.2026.08.025 [doi] PST - ppublish SO - J Psychiatr Res. 2026 Dec;203:33-40. doi: 10.1016/j.jpsychires.2026.08.025. Epub 2026 Sep 4. PMID- 42709217 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20261025 IS - 1436-6215 (Electronic) IS - 1436-6207 (Print) IS - 1436-6207 (Linking) VI - 65 IP - 7 DP - 2026 Sep 8 TI - Association of the maternal fish and PUFA intake with the risk of hypertensive disorders of pregnancy: a nationwide birth cohort-The Japan Environment and Children's Study (JECS). LID - 10.1007/s00394-026-04103-7 [doi] LID - 249 AB - PURPOSE: Hypertensive disorders of pregnancy (HDP) are a leading cause of maternal and perinatal morbidity. Although n-3 polyunsaturated fatty acids (PUFAs) in fish may prevent HDP, evidence from Japanese populations, particularly regarding the preconception period, remains limited. To examine associations between fish and PUFA intake before and during pregnancy and the risk of HDP using data from a nationwide Japanese birth cohort. METHODS: This analysis included 86,009 women from the Japan Environment and Children's Study. Dietary fish and n-3/n-6 PUFAs intake was assessed using a validated food-frequency questionnaire administered in early pregnancy (median gestational age, 15.0 weeks [interquartile range (IQR) 12.0-19.0]) to capture intake before pregnancy, and in mid to late pregnancy (median gestational age, 27.0 weeks [IQR 25.0-30.0]). Participants were categorized into quintiles of intake. Logistic regression models were used to estimate adjusted odds ratios (aORs) and 95% confidence intervals (CIs) for HDP, early-onset HDP (Eo-HDP < 32 weeks), and late-onset HDP (Lo-HDP >/= 32 weeks). Missing data were addressed with multiple imputation. RESULTS: In the overall population, higher fish intake before pregnancy was associated with reduced risks of Eo-HDP in the Q5 groups, whereas higher fish intake during pregnancy was associated with reduced risks of overall HDP in Q4. In analyses restricted to nulliparous women, higher pre-pregnancy fish intake was associated with a lower risk of Eo-HDP (Q4: aOR 0.57; 95% CI 0.34-0.97; p for trend = 0.02), and higher fish intake during pregnancy was associated with a lower risk of Lo-HDP (Q4: aOR 0.79; 95% CI 0.64-0.96). Total n-3 PUFA intake showed significant associations with HDP only in some analyses. Sensitivity analyses using a 34-week cutoff yielded consistent results. CONCLUSION: Fish intake before pregnancy was associated with lower risk of Eo-HDP, whereas intake during pregnancy was linked to reduced risk of Lo-HDP. Sustained fish consumption from preconception through pregnancy may help prevent HDP and inform global nutritional guidance, including preconception care. TRIAL REGISTRATION: The Japan Environment and Children's Study, https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000035091 (Registration no. UMIN000030786). CI - (c) 2026. The Author(s). FAU - Inouye, Takuya AU - Inouye T AUID- ORCID: 0009-0008-9827-6887 AD - Department of Obstetrics and Gynecology, Gunma University Graduate School of Medicine, Gunma, Japan. AD - Toyama Regional Center for JECS, University of Toyama, Toyama, Japan. FAU - Higeta, Daisuke AU - Higeta D AUID- ORCID: 0000-0002-6981-9722 AD - Department of Obstetrics and Gynecology, Gunma University Graduate School of Medicine, Gunma, Japan. FAU - Hamazaki, Kei AU - Hamazaki K AUID- ORCID: 0000-0003-0456-6805 AD - Department of Public Health Faculty of Medicine, Gunma University Graduate School of Medicine, Showa 3 Maebashi, Gunma, Japan. kei.hamazaki@gunma-u.ac.jp. AD - Department of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan. kei.hamazaki@gunma-u.ac.jp. AD - Toyama Regional Center for JECS, University of Toyama, Toyama, Japan. kei.hamazaki@gunma-u.ac.jp. FAU - Iwase, Akira AU - Iwase A AUID- ORCID: 0000-0002-0031-884X AD - Department of Obstetrics and Gynecology, Gunma University Graduate School of Medicine, Gunma, Japan. FAU - Tsuchida, Akiko AU - Tsuchida A AUID- ORCID: 0000-0003-1209-3104 AD - Department of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan. AD - Toyama Regional Center for JECS, University of Toyama, Toyama, Japan. FAU - Inadera, Hidekuni AU - Inadera H AUID- ORCID: 0000-0002-3548-221X AD - Department of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan. AD - Toyama Regional Center for JECS, University of Toyama, Toyama, Japan. FAU - Yoshioka, Eiji AU - Yoshioka E AUID- ORCID: 0000-0003-3316-1057 AD - Department of Public Health, Faculty of Medicine, University of Toyama, Toyama, Japan. AD - Toyama Regional Center for JECS, University of Toyama, Toyama, Japan. CN - Japan Environment and Children's Study Group LA - eng PT - Journal Article DEP - 20260908 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 RN - 0 (Fatty Acids, Omega-3) RN - 0 (Fatty Acids, Omega-6) SB - IM MH - Female MH - Humans MH - Pregnancy MH - Japan/epidemiology MH - Animals MH - *Hypertension, Pregnancy-Induced/epidemiology/prevention & control MH - Adult MH - *Seafood MH - *Fishes MH - *Fatty Acids, Omega-3/administration & dosage MH - *Diet/methods MH - Birth Cohort MH - *Fatty Acids, Omega-6/administration & dosage MH - *Maternal Nutritional Physiological Phenomena MH - Risk Factors MH - Odds Ratio MH - Cohort Studies MH - Logistic Models MH - Surveys and Questionnaires MH - Gestational Age PMC - PMC13553602 OTO - NOTNLM OT - Birth cohort OT - Fish OT - Hypertensive disorder of pregnancy OT - Polyunsaturated fatty acids OT - Preconception care COIS- Declarations. Competing interests: KH has received lecture honoraria from Sumitomo Pharma Co., Ltd., Suntory Wellness Ltd., JCR Pharmaceuticals Co., Ltd., Otsuka Pharmaceutical Co., Ltd., Pfizer Japan Inc., and Kensho Pharmaceutical Co., Ltd., for presentations related to n-3 PUFAs. All other authors report no conflicts of interest. Declaration of Generative AI and AI-assisted technologies in the writing process: During the preparation of this manuscript, the authors did not use any generative artificial intelligence or AI-assisted technologies for writing, editing, or content generation. The authors take full responsibility for the integrity and originality of the content.ss EDAT- 2026/09/08 17:36 MHDA- 2026/09/08 17:37 PMCR- 2026/09/08 CRDT- 2026/09/08 11:19 PHST- 2026/05/06 00:00 [received] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/08 17:37 [medline] PHST- 2026/09/08 17:36 [pubmed] PHST- 2026/09/08 11:19 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - 10.1007/s00394-026-04103-7 [pii] AID - 4103 [pii] AID - 10.1007/s00394-026-04103-7 [doi] PST - epublish SO - Eur J Nutr. 2026 Sep 8;65(7):249. doi: 10.1007/s00394-026-04103-7. PMID- 42708126 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260908 LR - 20260909 IS - 2523-2754 (Electronic) IS - 2310-2594 (Print) IS - 2523-2794 (Linking) VI - 14 IP - 3 DP - 2026 Jul-Sep TI - Development and validation of a Spanish-language questionnaire to assess mothers' knowledge and practices regarding their children's oral health. PG - e299 LID - 10.21142/2523-2754-1403-2026-299 [doi] LID - e299 AB - OBJECTIVE: This study aimed to design and validate a Spanish-language questionnaire to assess mothers' knowledge and practices regarding their children's oral health. MATERIAL AND METHODS: An exploratory study with a descriptive scope was conducted using both quantitative and qualitative data collection techniques and instruments, following these phases: 1) Review of relevant scientific literature; 2) Identification of core items and development of the preliminary instrument; 3) Preliminary pilot testing with an expert panel; 4) Semantic testing of the questionnaire in the target population; 5) Assessment of the instrument's reliability and reproducibility; 6) Validation of the instrument's appearance and content through two rounds with subject matter experts, including the calculation of various validity indicators: Content Validity Index (CVI), Content Validity Ratio (CVR), and Content Validity Coefficient (CVC). RESULTS: An assessment instrument was developed comprising 31 items that capture information across three dimensions: 1) psychosocial (attitudinal and relational); 2) knowledge; and 3) practices. All dimensions addressed aspects related to breastfeeding and nutrition, hygiene, and oral health within the mother-child dyad. Expert validation rounds produced CVI, CVR, and CVC values calculated for each item (I), dimension (S), and for the overall instrument (S). All scores exceeded the established thresholds (CVI >/= 0.78/0.90; CVR >/= 0.37/0.70; and CVC >/= 0.90), indicating adequate content validity. Minor wording and structural adjustments were made to some questions based on expert feedback. CONCLUSION: This study resulted in the development of a Spanish-language assessment instrument with adequate content and face validity, which is useful for designing educational strategies targeting the mother-child dyad to promote proper oral health. FAU - Arias-Mendoza, Martha J AU - Arias-Mendoza MJ AUID- ORCID: 0000-0003-2406-946X AD - Faculty of Dentistry, Universidad Santo Tomas. Santander, Colombia. ethman.torres@ustabuca.edu.co Universidad Santo Tomas Faculty of Dentistry Universidad Santo Tomas Santander Colombia ethman.torres@ustabuca.edu.co. FAU - Agudelo-Suarez, Andres A AU - Agudelo-Suarez AA AUID- ORCID: 0000-0002-8079-807X AD - Faculty of Dentistry, Universidad Cooperativa de Colombia. Medellin, Colombia. alonso.agudelo@udea.edu.co, emilia.ochoa@campusucc.edu.co Universidad Cooperativa de Colombia Faculty of Dentistry Universidad Cooperativa de Colombia Medellin Colombia alonso.agudelo@udea.edu.co emilia.ochoa@campusucc.edu.co. FAU - Ochoa-Acosta, Emilia M AU - Ochoa-Acosta EM AUID- ORCID: 0000-0001-6765-5712 AD - Faculty of Dentistry, Universidad Cooperativa de Colombia. Medellin, Colombia. alonso.agudelo@udea.edu.co, emilia.ochoa@campusucc.edu.co Universidad Cooperativa de Colombia Faculty of Dentistry Universidad Cooperativa de Colombia Medellin Colombia alonso.agudelo@udea.edu.co emilia.ochoa@campusucc.edu.co. FAU - Torres-Murillo, Ethman A AU - Torres-Murillo EA AUID- ORCID: 0000-0003-1603-8380 AD - Faculty of Dentistry, Universidad Santo Tomas. Santander, Colombia. ethman.torres@ustabuca.edu.co Universidad Santo Tomas Faculty of Dentistry Universidad Santo Tomas Santander Colombia ethman.torres@ustabuca.edu.co. FAU - Concha-Sanchez, Sonia C AU - Concha-Sanchez SC AUID- ORCID: 0000-0003-3092-520X AD - Public Health Department, Universidad de Santander. Bucaramanga, Colombia. sococosa@yahoo.com Universidad de Santander Public Health Department Universidad de Santander Bucaramanga Colombia sococosa@yahoo.com. LA - eng PT - Journal Article DEP - 20260710 PL - Peru TA - Rev Cient Odontol (Lima) JT - Revista cientifica odontologica (Universidad Cientifica del Sur) JID - 9918697384606676 PMC - PMC13549665 OTO - NOTNLM OT - Health Education OT - Health Knowledge, Attitudes, Practice OT - Health Promotion OT - Oral Health OT - Validation Study COIS- Conflict of Interest: The authors declare no conflict of interest related to this study. EDAT- 2026/09/08 12:33 MHDA- 2026/09/08 12:34 PMCR- 2026/07/10 CRDT- 2026/09/08 06:52 PHST- 2025/12/11 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/09/08 12:34 [medline] PHST- 2026/09/08 12:33 [pubmed] PHST- 2026/09/08 06:52 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - 10.21142/2523-2754-1403-2026-299 [doi] PST - epublish SO - Rev Cient Odontol (Lima). 2026 Jul 10;14(3):e299. doi: 10.21142/2523-2754-1403-2026-299. eCollection 2026 Jul-Sep. PMID- 42707981 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260908 LR - 20260909 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Enhancing healthy eating and active environments in early learning settings: findings from the eHealth study. PG - 1873291 LID - 10.3389/fnut.2026.1873291 [doi] LID - 1873291 AB - INTRODUCTION: Early childhood educators are important influencers of children's eating and activity behaviors, making them key targets for interventions aimed at improving nutrition and physical activity practices and fostering healthier childcare environments. OBJECTIVE: To evaluate the impact of the eHealth professional development program in improving early childhood education and care (ECEC) nutrition and physical activity environments, educators' nutrition knowledge, attitudes, and behaviors, and educators' perceptions of program acceptability. METHOD: This study was conducted in licensed ECEC centers in one Canadian province. The study used a two-armed quasi-experimental pre-test/post-test design with intervention and control groups and repeated measures to evaluate a 10-month eHealth program informed by Social Cognitive Theory and the Interconnected Model of Professional Growth Theory. The program aimed to enhance educators' capacity to implement evidence-based nutrition and physical activity practices. Delivered in annual cohorts from 2019 to 2021, it comprised two phases: (1) a 12-week series of online educational modules with accompanying virtual Communities of Practice meetings, and (2) a five-month follow-up period involving monthly implementation-coaching virtual Communities of Practice meetings. Validated questionnaires assessed center-level and educator-level outcomes at baseline, five (midpoint), and 10 months (end-of-program). Semi-structured interviews explored perceptions of program acceptability. RESULTS: Compared with controls, significant improvements in center-level nutrition and physical activity environments (mean change 0.362, p = 0.002, Cohen's d = 0.72), and educator nutrition knowledge, attitudes, and behaviors (mean change 5.467, p = 0.023, Cohen's d = 0.69) were observed at midpoint and maintained at the end-of-program. Qualitative findings indicated high acceptability, with educators describing the program as relevant, feasible, and supportive of integrating practices into daily routines. CONCLUSION: The eHealth professional development program was acceptable and associated with improvements in educators' knowledge and adherence to nutrition and physical activity practice guidelines, with sustained effect over time. Scalable, digitally delivered professional development may offer a promising strategy to support healthier ECEC environments. CI - Copyright (c) 2026 Lafave, Hayek, McConnell and Winkens. FAU - Lafave, Lynne M Z AU - Lafave LMZ AD - CHEERS Lab, Department Health and Physical Education, Mount Royal University, Calgary, AB, Canada. FAU - Hayek, Joyce AU - Hayek J AD - CHEERS Lab, Department Health and Physical Education, Mount Royal University, Calgary, AB, Canada. FAU - McConnell, Ceilidh AU - McConnell C AD - CHEERS Lab, Department Health and Physical Education, Mount Royal University, Calgary, AB, Canada. FAU - Winkens, Bjorn AU - Winkens B AD - Faculty of Health, Medicine and Life Sciences, Care and Public Health Research Institute (CAPHRI), Department of Methodology and Statistics, Maastricht University, Maastricht, Netherlands. LA - eng PT - Journal Article DEP - 20260824 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13548801 OTO - NOTNLM OT - eHealth intervention OT - early childhood education and care OT - interconnected model of professional growth OT - linear mixed models OT - nutrition OT - physical activity OT - professional development OT - social cognitive theory COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/08 12:33 MHDA- 2026/09/08 12:34 PMCR- 2026/08/24 CRDT- 2026/09/08 06:41 PHST- 2026/05/05 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/09/08 12:34 [medline] PHST- 2026/09/08 12:33 [pubmed] PHST- 2026/09/08 06:41 [entrez] PHST- 2026/08/24 00:00 [pmc-release] AID - 10.3389/fnut.2026.1873291 [doi] PST - epublish SO - Front Nutr. 2026 Aug 24;13:1873291. doi: 10.3389/fnut.2026.1873291. eCollection 2026. PMID- 42707971 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260908 LR - 20260909 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Artificial intelligence in child nutrition and eating behavior: from prediction to gastronomic mediation. PG - 1952364 LID - 10.3389/fnut.2026.1952364 [doi] LID - 1952364 AB - Artificial intelligence (AI) is entering child nutrition through dietary assessment, malnutrition forecasting, clinical decision support, meal recommendation, conversational interventions, and food-environment monitoring. The consequences of these applications converge in everyday eating. This Mini Review synthesizes evidence on how AI measures nutritional states and mediates food choice, communication, sensory acceptance, family practice, and digital exposure. The evidence supports two connected functions. As nutritional intelligence, AI converts clinical, dietary, and environmental data into assessments or predictions. As gastronomic mediation, it participates in decisions about what foods are noticed, recommended, prepared, discussed, and accepted. Direct pediatric validation is strongest for bounded assessment and forecasting tasks. Child meal-planning studies and generative-AI evaluations based on standardized adolescent profiles reveal a gap between nutrient optimization, culinary coherence, and nutritional safety. A large adolescent chatbot trial combined scalable delivery with null intention-to-treat effects on diet quality and BMI trajectory. Co-design and behavioral studies further identify familiarity, texture, participation, and caregiver involvement as central design variables. We propose five iterative translational gates: technical validity, nutritional validity, behavioral acceptability, contextual legitimacy, and real-world effectiveness and implementation. Future research should combine age-specific nutritional constraints with sensory and cultural knowledge, evaluate performance across food cultures, preserve professional and caregiver oversight, and test outcomes in homes, schools, clinics, and digital food environments. AI can advance child-focused gastronomy by translating computational outputs into safe, culturally meaningful, and developmentally appropriate eating practices. CI - Copyright (c) 2026 Xing and Wu. FAU - Xing, Lu AU - Xing L AD - School of Preschool Education, Changsha Normal University, Changsha, China. AD - School of Education, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. FAU - Wu, Xueqi AU - Wu X AD - Taylor's Culinary Institute, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. LA - eng PT - Journal Article PT - Review DEP - 20260824 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13548810 OTO - NOTNLM OT - artificial intelligence OT - child nutrition OT - child-centered design OT - digital food environment OT - eating behavior OT - food culture OT - gastronomy OT - personalized nutrition COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/08 12:33 MHDA- 2026/09/08 12:34 PMCR- 2026/08/24 CRDT- 2026/09/08 06:38 PHST- 2026/07/29 00:00 [received] PHST- 2026/08/10 00:00 [revised] PHST- 2026/08/12 00:00 [accepted] PHST- 2026/09/08 12:34 [medline] PHST- 2026/09/08 12:33 [pubmed] PHST- 2026/09/08 06:38 [entrez] PHST- 2026/08/24 00:00 [pmc-release] AID - 10.3389/fnut.2026.1952364 [doi] PST - epublish SO - Front Nutr. 2026 Aug 24;13:1952364. doi: 10.3389/fnut.2026.1952364. eCollection 2026. PMID- 42707362 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260908 LR - 20260909 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Nutrition education and behavioral interventions in youth team-sport and related development settings: a systematic review of nutrition knowledge, dietary behaviors, hydration, body composition, and performance. PG - 1939289 LID - 10.3389/fnut.2026.1939289 [doi] LID - 1939289 AB - INTRODUCTION: Nutrition knowledge and the ability to translate it into appropriate food and hydration choices are important for health, development, recovery, and performance in young athletes. However, evidence on nutrition interventions in youth team-sport settings remains dispersed across sports, educational formats, and outcome domains. This systematic review aimed to synthesize evidence on nutrition education, hydration education, dietary counseling, digital tools, controlled dietary modification, and multicomponent interventions in child, adolescent, and late-adolescent development settings. METHODS: The review followed PRISMA 2020 guidelines and was registered in PROSPERO (CRD420261441507). PubMed/MEDLINE, Scopus, Web of Science Core Collection, SPORTDiscus/EBSCO, and Cochrane CENTRAL were searched from inception to 3 July 2026. Two reviewers independently screened reports, extracted data, and assessed risk of bias using RoB 2 or ROBINS-I. Because of substantial heterogeneity in interventions and outcomes, findings were synthesized narratively. RESULTS: Database searches identified 419 records. After duplicate removal and screening, 46 full-text reports were assessed, 19 were excluded, and 27 unique studies were included. Soccer/football predominated, with additional evidence from volleyball, basketball, handball, baseball, hockey, American football, and mixed-sport settings. Nutrition and sports nutrition knowledge showed the most consistent favorable changes. Findings for dietary intake, diet quality, body composition, biochemical markers, and performance were mixed. Hydration interventions showed clearer short-term improvements when education was combined with practical cues, improved fluid access, feedback, or individualized prescriptions. DISCUSSION: Nutrition interventions in youth team-sport and related development settings may support knowledge acquisition and selected hydration behaviors, but their effects on dietary behavior and physiological outcomes remain uncertain. Confidence in the evidence is limited by small samples, short follow-up periods, heterogeneous measures, reliance on self-report, incomplete fidelity reporting, and risk-of-bias concerns. Future trials should use validated age-appropriate measures, objective outcomes, longer follow-up, prespecified analyses, and implementation strategies involving athletes, families, coaches, schools, and clubs. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261441507, CRD420261441507. CI - Copyright (c) 2026 Victoria-Montesinos, Garcia-Munoz, Mercader-Ros, Jaraba-Salinero and Figueroa-Morales. FAU - Victoria-Montesinos, Desiree AU - Victoria-Montesinos D AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, Murcia, Spain. FAU - Garcia-Munoz, Ana Maria AU - Garcia-Munoz AM AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, Murcia, Spain. FAU - Mercader-Ros, Maria Teresa AU - Mercader-Ros MT AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, Murcia, Spain. FAU - Jaraba-Salinero, Yasmina AU - Jaraba-Salinero Y AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, Murcia, Spain. FAU - Figueroa-Morales, Fernando AU - Figueroa-Morales F AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, Murcia, Spain. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260824 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13547255 OTO - NOTNLM OT - adolescents OT - body composition OT - children OT - dietary behavior OT - nutrition education OT - nutrition knowledge OT - sport performance OT - sports nutrition COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author DV-M declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/09/08 12:33 MHDA- 2026/09/08 12:34 PMCR- 2026/08/24 CRDT- 2026/09/08 05:37 PHST- 2026/07/16 00:00 [received] PHST- 2026/08/06 00:00 [revised] PHST- 2026/08/10 00:00 [accepted] PHST- 2026/09/08 12:34 [medline] PHST- 2026/09/08 12:33 [pubmed] PHST- 2026/09/08 05:37 [entrez] PHST- 2026/08/24 00:00 [pmc-release] AID - 10.3389/fnut.2026.1939289 [doi] PST - epublish SO - Front Nutr. 2026 Aug 24;13:1939289. doi: 10.3389/fnut.2026.1939289. eCollection 2026. PMID- 42706523 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260910 IS - 1471-2466 (Electronic) IS - 1471-2466 (Linking) VI - 26 IP - 1 DP - 2026 Sep 7 TI - Moving beyond treatment: pulmonary function, autonomous motivation, and physical activity enjoyment in adults with cystic fibrosis. LID - 10.1186/s12890-026-04661-w [doi] LID - 400 AB - BACKGROUND: Physical activity (PA) and structured exercise are established cornerstones of cystic fibrosis (CF) management. While CFTR modulators have transformed treatment, the psychological factors affecting sustained PA adherence, particularly motivational regulation and PA enjoyment, require further investigation. This study aimed to determine whether percent predicted forced expiratory volume in one second (ppFEV(1)) is independently associated with autonomous motivation and PA enjoyment in adults with CF, after adjusting for CFTR modulator therapy status and sex. METHODS: A cross-sectional study was conducted at a specialised CF centre (N = 200). Participants completed validated questionnaires assessing motivational regulation (Behavioural Regulation Questionnaire-2, BREQ-2) and PA enjoyment (Physical Activity Enjoyment Scale, PACES). Clinical data, including the ppFEV(1), were obtained from medical records. Multivariate general linear models (GLM), partial correlations, and hierarchical regression analyses were utilised. RESULTS: Cross-sectional analyses showed that ppFEV(1) was independently associated with intrinsic motivation (beta = .233, p < .001), the relative autonomy index (RAI) (beta = .203, p = .004) and the PACES total score (beta = .201, p = .004). After CFTR modulator therapy status and sex were accounted for, the additional variance explained by the ppFEV(1) was statistically significant but modest (DeltaR(2) = .054, .041, and .040, respectively). Neither the CFTR modulator therapy status nor sex was significantly associated with the assessed motivational or enjoyment outcomes. CONCLUSIONS: Although ppFEV(1) showed small, independent associations with autonomous motivational regulation and PA enjoyment in adults with CF, lung function should not be used as a proxy for motivational support needs. To provide person-centred, SDT-informed support that encourages sustained participation in PA, the motivational regulation and enjoyment of PA should be assessed directly in adults with CF. CI - (c) 2026. The Author(s). FAU - Gruber, Wolfgang AU - Gruber W AUID- ORCID: 0000-0003-2186-9269 AD - Paediatric Pulmonology and Sleep Medicine, Cystic Fibrosis Centre, Children S Hospital, University of Duisburg-Essen, 45147, Essen, Germany. wolfgang.gruber@uk-essen.de. AD - Fachklinik Satteldune der DRV Nord, Nebel/Amrum, Germany. wolfgang.gruber@uk-essen.de. FAU - Welsner, Matthias AU - Welsner M AD - Department of Pulmonary Medicine, Adult Cystic Fibrosis Center, University Hospital Essen - Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany. FAU - Stehling, Florian AU - Stehling F AD - Paediatric Pulmonology and Sleep Medicine, Cystic Fibrosis Centre, Children S Hospital, University of Duisburg-Essen, 45147, Essen, Germany. FAU - Schermaul, Jin-Sun AU - Schermaul JS AD - Department of Pulmonary Medicine, Adult Cystic Fibrosis Center, University Hospital Essen - Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany. FAU - Ortiz, Jose G AU - Ortiz JG AD - Department of Pulmonary Medicine, Adult Cystic Fibrosis Center, University Hospital Essen - Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany. FAU - Lechtenberg, Liron AU - Lechtenberg L AD - Department of Pulmonary Medicine, Adult Cystic Fibrosis Center, University Hospital Essen - Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany. FAU - Taube, Christian AU - Taube C AD - Department of Pulmonary Medicine, Adult Cystic Fibrosis Center, University Hospital Essen - Ruhrlandklinik, University of Duisburg-Essen, Essen, Germany. FAU - Olivier, Margarete AU - Olivier M AD - Paediatric Pulmonology and Sleep Medicine, Cystic Fibrosis Centre, Children S Hospital, University of Duisburg-Essen, 45147, Essen, Germany. LA - eng PT - Journal Article DEP - 20260907 PL - England TA - BMC Pulm Med JT - BMC pulmonary medicine JID - 100968563 SB - IM MH - Humans MH - *Motivation MH - Male MH - Female MH - Cross-Sectional Studies MH - *Cystic Fibrosis/psychology/physiopathology/therapy MH - Adult MH - Forced Expiratory Volume MH - Surveys and Questionnaires MH - *Exercise/psychology MH - Young Adult MH - Linear Models MH - Adolescent PMC - PMC13548599 OTO - NOTNLM OT - Autonomous motivation OT - CFTR modulator therapy OT - Cystic fibrosis OT - Physical activity enjoyment OT - Pulmonary function OT - Self-determination theory OT - Sex COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Medical Ethics Committee of the University of Duisburg-Essen (24-11951-BO). Written informed consent was obtained from all participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/08 05:36 MHDA- 2026/09/08 05:37 PMCR- 2026/09/07 CRDT- 2026/09/08 00:06 PHST- 2026/04/13 00:00 [received] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/09/08 05:37 [medline] PHST- 2026/09/08 05:36 [pubmed] PHST- 2026/09/08 00:06 [entrez] PHST- 2026/09/07 00:00 [pmc-release] AID - 10.1186/s12890-026-04661-w [pii] AID - 4661 [pii] AID - 10.1186/s12890-026-04661-w [doi] PST - epublish SO - BMC Pulm Med. 2026 Sep 7;26(1):400. doi: 10.1186/s12890-026-04661-w. PMID- 42705712 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260929 IS - 1873-7145 (Electronic) IS - 0963-9969 (Linking) VI - 243 IP - Pt 2 DP - 2026 Nov 1 TI - Sheep milk proteins: current research on nutritional characteristics, biofunctional properties, and application potentials. PG - 120247 LID - S0963-9969(26)01934-4 [pii] LID - 10.1016/j.foodres.2026.120247 [doi] AB - BACKGROUND: Sheep milk proteins (SMPs) are key nutritional and functional components of sheep milk and have attracted increasing interest because of their high digestibility, distinctive compositional profile, and reported bioactivities. Compared with bovine milk proteins, SMPs contain a high proportion of beta-casein, relatively low alphas1-casein, and multiple low-abundance bioactive proteins and peptides. However, their high value utilization remains limited by uneven global milk supply, raw-material variability, challenges in separation and purification, and insufficient in vivo and clinical evidence. SCOPE AND APPROACH: This review focuses specifically on sheep milk proteins as nutritional, structural, functional, and industrial. It summarizes sheep milk production, SMP composition and nutrition, and factors affecting SMP yield and quality, including breed, lactation stage, parity, genotype, season, and nutritional status. Enrichment, separation, purification, and identification strategies are critically evaluated, together with reported bioactivities and food related application potential. KEY FINDINGS AND CONCLUSIONS: SMPs are promising multifunctional ingredients for dairy innovation, infant nutrition, and bio-based food materials. Their value should not be inferred from protein abundance alone, but from the combined effects of protein composition, casein micelle structure, digestion-derived peptide release, bioaccessibility, and processing feasibility. However, translation remains constrained by inconsistent raw-material supply, compositional variation, limited structure and activity understanding, and the predominance of preclinical evidence. Future studies should prioritize ACE-inhibitory and DPP-IV-inhibitory sheep milk peptides by validating their structure activity relationships, bioavailability, and in vivo mechanisms in relevant cardiometabolic models. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Wen, Qinghua AU - Wen Q AD - College of Animal Science and Technology, Northwest A&F University, Yangling, Shannxi 712100, China. FAU - Liu, Xiaorui AU - Liu X AD - Division of Laboratory Safety and Services, Northwest A&F University, Yangling, Shaanxi 712100, China. FAU - Sun, Lei AU - Sun L AD - College of Animal Science and Technology, Northwest A&F University, Yangling, Shannxi 712100, China. FAU - Jiang, Yue AU - Jiang Y AD - College of Animal Science and Technology, Northwest A&F University, Yangling, Shannxi 712100, China. FAU - Liu, Jiaxin AU - Liu J AD - College of Animal Science and Technology, Northwest A&F University, Yangling, Shannxi 712100, China. FAU - Kraithong, Supaluck AU - Kraithong S AD - Guangxi Key Laboratory of Marine Drugs, Institute of Marine Drugs, Guangxi University of Chinese Medicine, Nanning 530200, China. FAU - Ahmad, Naseer AU - Ahmad N AD - College of Animal Science and Technology, Northwest A&F University, Yangling, Shannxi 712100, China. FAU - Song, Yuxuan AU - Song Y AD - College of Animal Science and Technology, Northwest A&F University, Yangling, Shannxi 712100, China. Electronic address: xuyuan_song2016@163.com. FAU - Zhang, Lei AU - Zhang L AD - College of Animal Science and Technology, Northwest A&F University, Yangling, Shannxi 712100, China. Electronic address: zhanglei07dongke@163.com. LA - eng PT - Journal Article PT - Review DEP - 20260810 PL - Canada TA - Food Res Int JT - Food research international (Ottawa, Ont.) JID - 9210143 RN - 0 (Bioactive Peptides, Dietary) RN - 0 (Caseins) RN - 0 (Milk Proteins) SB - IM MH - Animals MH - Humans MH - Bioactive Peptides, Dietary MH - Caseins/analysis MH - Lactation MH - *Milk/chemistry MH - *Milk Proteins/chemistry/analysis MH - *Nutritive Value MH - Sheep OTO - NOTNLM OT - Bioactivity OT - Dairy innovation OT - Functional ingredients OT - Separation technologies OT - Sheep milk proteins COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/07 23:34 MHDA- 2026/09/07 23:35 CRDT- 2026/09/07 20:53 PHST- 2026/05/11 00:00 [received] PHST- 2026/07/30 00:00 [revised] PHST- 2026/08/01 00:00 [accepted] PHST- 2026/09/07 23:35 [medline] PHST- 2026/09/07 23:34 [pubmed] PHST- 2026/09/07 20:53 [entrez] AID - S0963-9969(26)01934-4 [pii] AID - 10.1016/j.foodres.2026.120247 [doi] PST - ppublish SO - Food Res Int. 2026 Nov 1;243(Pt 2):120247. doi: 10.1016/j.foodres.2026.120247. Epub 2026 Aug 10. PMID- 42705026 OWN - NLM STAT- MEDLINE DCOM- 20260922 LR - 20260922 IS - 1090-2414 (Electronic) IS - 0147-6513 (Linking) VI - 323 DP - 2026 Sep 15 TI - Associations between urinary phthalate and benzophenone metabolites and early puberty timing in girls. PG - 120758 LID - S0147-6513(26)01088-2 [pii] LID - 10.1016/j.ecoenv.2026.120758 [doi] AB - Phthalates (PAEs) and benzophenones (BPs) are ubiquitous endocrine-disrupting chemicals, and exposure to them is thought to disrupt pubertal development. However, epidemiological evidence regarding their real-world, combined associations with early puberty timing (EPT) in girls remains limited and inconsistent. This case-control study enrolled a total of 147 girls, comprising 63 EPT cases and 84 healthy controls. Urinary concentrations of seven PAE and two BP metabolites were quantified. Single-pollutant associations and exposure-response relationships were evaluated using multivariable logistic regression and restricted cubic splines (RCS). To investigate potential modification of these associations by weight status, we conducted subgroup analyses. Furthermore, the overall joint association of the chemical mixture was quantified applying Bayesian kernel machine regression (BKMR) and quantile g-computation (Qgcomp). In single-pollutant models, MnBP, BP-8, MODP, and MMP were positively associated with the risk of EPT. Stratified analyses indicated that these associations remained consistent across different weight strata, with no significant interaction by weight status. In multi-pollutant analyses, Qgcomp revealed a significant positive joint association of the chemical mixture with EPT (OR=1.36; 95% CI: 1.12, 1.65), which was consistently supported by the BKMR models. Notably, MnBP and BP-8 emerged as the primary contributors of this combined association. Our findings highlight that co-exposure to specific PAE and BP metabolites, particularly MnBP and BP-8, is positively associated with EPT in girls. Future prospective cohorts are necessary to validate these results and uncover the biological pathways. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Li, Zhi AU - Li Z AD - Clinical Research Unit, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Tang, Jingyi AU - Tang J AD - Clinical Research Unit, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Department of Clinical Epidemiology and Biostatistics, Shanghai Childre's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. FAU - Chen, Yang AU - Chen Y AD - Clinical Research Unit, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Department of Clinical Epidemiology and Biostatistics, Shanghai Childre's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. FAU - Kong, Huijun AU - Kong H AD - Department of Pediatrics, Qufu People's Hospital, Qufu, Shandong 273160, China. FAU - Lin, Cuilan AU - Lin C AD - Boai Hospital of Zhongshan, Southern Medical University, Zhongshan, Guangdong 528405, China. FAU - Tong, Shilu AU - Tong S AD - School of Public Health and Social Work, Queensland University of Technology, Brisbane, Australia; National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing, China. FAU - Liu, Shijian AU - Liu S AD - Clinical Research Unit, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Department of Clinical Epidemiology and Biostatistics, Shanghai Childre's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: shijianliu@shsmu.edu.cn. LA - eng PT - Journal Article DEP - 20260907 PL - Netherlands TA - Ecotoxicol Environ Saf JT - Ecotoxicology and environmental safety JID - 7805381 RN - 0 (Phthalic Acids) RN - 0 (Benzophenones) RN - 0 (Environmental Pollutants) RN - 6O7F7IX66E (phthalic acid) RN - 0 (Endocrine Disruptors) RN - 701M4TTV9O (benzophenone) SB - IM MH - Female MH - Humans MH - *Phthalic Acids/urine MH - *Benzophenones/urine MH - Case-Control Studies MH - *Environmental Pollutants/urine MH - Child MH - *Endocrine Disruptors/urine MH - Environmental Exposure/adverse effects/analysis MH - Bayes Theorem MH - *Puberty/drug effects OTO - NOTNLM OT - Benzophenones OT - Early puberty timing OT - Environmental epidemiology OT - Mixture exposure OT - Phthalates COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/07 23:34 MHDA- 2026/09/22 05:37 CRDT- 2026/09/07 18:02 PHST- 2026/05/25 00:00 [received] PHST- 2026/08/22 00:00 [revised] PHST- 2026/09/02 00:00 [accepted] PHST- 2026/09/22 05:37 [medline] PHST- 2026/09/07 23:34 [pubmed] PHST- 2026/09/07 18:02 [entrez] AID - S0147-6513(26)01088-2 [pii] AID - 10.1016/j.ecoenv.2026.120758 [doi] PST - ppublish SO - Ecotoxicol Environ Saf. 2026 Sep 15;323:120758. doi: 10.1016/j.ecoenv.2026.120758. Epub 2026 Sep 7. PMID- 42704402 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260910 IS - 2196-1042 (Electronic) IS - 1723-7785 (Print) IS - 1723-7785 (Linking) VI - 27 IP - 1 DP - 2026 Sep 7 TI - Morphological variations and differences of the mandible and midfacial skeleton across different sagittal skeletal patterns and sexes: a three-dimensional geometric morphometric analysis. LID - 10.1186/s40510-026-00645-y [doi] LID - 39 AB - BACKGROUND: Maxillofacial morphological analysis is essential for orthodontic diagnosis, treatment planning, and outcome evaluation. However, previous two-dimensional or landmark-based studies can hardly comprehensively analyze three-dimensional morphology. Therefore, this study aimed to analyze morphological variations and differences of the mandible and midfacial skeleton across different sagittal skeletal patterns and sexes using three-dimensional geometric morphometrics, while also providing novel perspectives and methodologies for morphological analysis in orthodontics. METHODS: The midfacial skeleton and mandible were analyzed separately. Three-dimensional dense templates were first constructed and template registration was validated. Through template registration, all segmented skeleton images (n = 186) obtained a homologous configuration with tens of thousands of quasi-landmarks. After generalized Procrustes analysis, principal component analysis (PCA) was conducted to examine shape variations. The average skeletal shapes were calculated and compared according to sagittal skeletal pattern and sex. Partial least squares regression (PLSR) was used to evaluate the independent effects of ANB angle and sex on skeletal shape. RESULTS: PCA revealed the principal patterns of shape variations. The first principal component (PC1) of the mandible primarily showed variation in sagittal length and inter-ramal width (explaining 31.80% of the total variance), whereas PC1 of the midfacial skeleton mainly showed variation in vertical height and inter-zygomatic width (24.07%). Morphological differences were demonstrated through comparisons of average skeletal shapes grouped by sagittal skeletal pattern or sex. PLSR indicated significant effects of ANB angle and sex on the three-dimensional morphology of both the mandible and midfacial skeleton (all P < 0.001). Specifically, with increasing ANB angle (skeletal Class II tendency), the length of the condyle (condylar head and neck) decreased, the antegonial notch became more prominent, and the maxillary alveolar bone plane rotated downward and backward (clockwise). Compared with females, males exhibited a more prominent mandibular angle, increased inter-zygomatic width, and more protrusive nasal bridge and anterior nasal spine. CONCLUSIONS: Three-dimensional dense geometric morphometrics enables a more comprehensive analysis of facial skeletal morphology. Three-dimensional morphological variations and differences of the mandible and midfacial skeleton across different sagittal skeletal patterns and sexes were characterized. CI - (c) 2026. The Author(s). FAU - Zhao, Guangpu AU - Zhao G AD - Department of Orthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China. FAU - Su, Xinyu AU - Su X AD - Department of Orthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China. FAU - He, Danqing AU - He D AD - Department of Orthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China. hedanqing@bjmu.edu.cn. FAU - Gu, Yan AU - Gu Y AUID- ORCID: 0000-0003-0108-4325 AD - Department of Orthodontics, Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, China. guyan96@126.com. LA - eng GR - L242130/Natural Science Foundation of Beijing Municipality/ GR - 7232217/Natural Science Foundation of Beijing Municipality/ GR - 82170996/National Natural Science Foundation of China/ GR - PKUSSNCT-25A04/Program for New Clinical Techniques and Therapies of Peking University School and Hospital of Stomatology/ PT - Journal Article DEP - 20260907 PL - Germany TA - Prog Orthod JT - Progress in orthodontics JID - 100936353 SB - IM MH - Humans MH - Female MH - *Mandible/anatomy & histology/diagnostic imaging MH - Male MH - *Imaging, Three-Dimensional/methods MH - Principal Component Analysis MH - *Facial Bones/anatomy & histology/diagnostic imaging MH - Cephalometry/methods MH - Sex Factors MH - Anatomic Landmarks MH - Sex Characteristics MH - Adolescent PMC - PMC13550393 OTO - NOTNLM OT - Geometric morphometrics OT - Mandible OT - Midfacial skeleton OT - Morphology OT - Sagittal skeletal pattern OT - Sex characteristics OT - Three-dimensional COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Biomedical Ethics Committee of Peking University School and Hospital of Stomatology (PKUSSIRB-202497034). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/07 17:36 MHDA- 2026/09/07 17:37 PMCR- 2026/09/07 CRDT- 2026/09/07 11:05 PHST- 2025/12/08 00:00 [received] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/09/07 17:37 [medline] PHST- 2026/09/07 17:36 [pubmed] PHST- 2026/09/07 11:05 [entrez] PHST- 2026/09/07 00:00 [pmc-release] AID - 10.1186/s40510-026-00645-y [pii] AID - 645 [pii] AID - 10.1186/s40510-026-00645-y [doi] PST - epublish SO - Prog Orthod. 2026 Sep 7;27(1):39. doi: 10.1186/s40510-026-00645-y. PMID- 42703816 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260907 LR - 20260912 IS - 1308-8734 (Print) IS - 1308-8742 (Electronic) IS - 1308-8734 (Linking) VI - 58 IP - 4 DP - 2026 Aug 20 TI - Association of Early and Late Postnatal Serum Lactate/Albumin Ratio and Retinopathy of Prematurity in Preterm Infants: A 2 Time Point Comparative Study. PG - 1-6 LID - 10.5152/eurasianjmed.2026.261457 [doi] LID - e261457 AB - BACKGROUND: One easily accessible compound index that shows the metabolic and inflammatory status of critically ill patients is the lactate-albumin ratio (LAR). This study set out to evaluate the connection between LAR and retinopathy of prematurity (ROP) in premature infants. METHODS: The investigation was conducted retrospectively on 150 premature infants born before 34 weeks who underwent screening for ROP in the neonatal intensive care unit. Demographic and clinical data, as well as ROP examination findings, were recorded for all participants. For the first 24 h following delivery (early phase) and at 34-36 weeks' postmenstrual age (late period), serum lactate and albumin values were measured separately. For each of these measurements, the lactate/albumin ratio was calculated. Mann-Whitney U-test, logistic regression, correlation analyses, together with receiver operating characteristic (ROC) analysis were performed. RESULTS: In infants who developed ROP, both the LAR calculated in the early phase (1.16 +/- 0.56, P = .03) and the LAR calculated in the late period (0.53 +/- 0.19, P = .02) were found to be significantly higher than those without ROP. In post hoc analyses based on disease severity, LAR values were significantly higher in the treatment-requiring ROP group (P = .02). In logistic regression, late-period LAR showed a borderline but statistically non-significant association with ROP development (OR = 11.05; 95% CI = 0.97-125.9; P = .053). CONCLUSION: Lactate-albumin ratio values were associated with ROP development and disease severity in premature infants. However, LAR was not demonstrated to be an independent predictor of ROP in the present study. As a composite index reflecting nutrition, inflammation, tissue oxygenation, and metabolic stress, LAR may provide complementary information regarding systemic vulnerability in premature infants rather than serving as a standalone predictive or screening biomarker. Further prospective and multicenter studies are needed to clarify its potential role in ROP risk assessment. Cite this article as: Caliskan B, Korkut D, Kara M, Tekgunduz KS. Association of early and late postnatal serum lactate/albumin ratio and retinopathy of prematurity in preterm infants: a 2 time point comparative study. Eurasian J Med. 2026, 58(4), 1457, doi: 10.5152/eurasianjmed.2026.261457. FAU - Caliskan, Busra AU - Caliskan B AUID- ORCID: 0000-0002-2350-184X AD - Department of Ophthalmology, Ataturk University Faculty of Medicine, Erzurum, Turkiye. FAU - Korkut, Dilara AU - Korkut D AUID- ORCID: 0009-0004-2163-4122 AD - Department of Neonatology, Ataturk University Faculty of Medicine,Erzurum, Turkiye. FAU - Kara, Mustafa AU - Kara M AUID- ORCID: 0000-0001-6568-1538 AD - Department of Neonatology, Ataturk University Faculty of Medicine,Erzurum, Turkiye. FAU - Tekgunduz, Kadir Serafettin AU - Tekgunduz KS AUID- ORCID: 0000-0001-6375-5644 AD - Department of Neonatology, Ataturk University Faculty of Medicine,Erzurum, Turkiye. LA - eng PT - Journal Article DEP - 20260820 PL - Turkey TA - Eurasian J Med JT - The Eurasian journal of medicine JID - 101557701 PMC - PMC13559898 OTO - NOTNLM OT - Albumin OT - biomarker OT - lactate OT - retinopathy of prematurity OT - the lactate-albumin ratio COIS- Declaration of Interests: The authors have no conflicts of interest to declare. EDAT- 2026/09/07 11:37 MHDA- 2026/09/07 11:38 PMCR- 2026/08/20 CRDT- 2026/09/07 05:44 PHST- 2026/08/20 00:00 [received] PHST- 2026/09/07 11:38 [medline] PHST- 2026/09/07 11:37 [pubmed] PHST- 2026/09/07 05:44 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - eajm-58-4-261457 [pii] AID - 10.5152/eurasianjmed.2026.261457 [doi] PST - epublish SO - Eurasian J Med. 2026 Aug 20;58(4):1-6. doi: 10.5152/eurasianjmed.2026.261457. PMID- 42703626 OWN - NLM STAT- Publisher LR - 20260910 IS - 1941-0921 (Electronic) IS - 1941-7381 (Print) IS - 1941-0921 (Linking) DP - 2026 Sep 7 TI - Feasibility and Clinical Utility of a Modified Step Test for Evaluating Exercise Intolerance After Pediatric and Adolescent Concussion in the Ambulatory Setting. PG - 19417381261477255 LID - 10.1177/19417381261477255 [doi] LID - 19417381261477255 AB - BACKGROUND: Exercise intolerance (EI) is an important component of concussion pathophysiology, serving as a predictor for persisting symptoms, as well as a therapeutic target. It traditionally requires bulky, expensive equipment such as a treadmill to assess. PURPOSE: To evaluate the feasibility of a modified step test to assess EI in youth with concussion and determine its clinical utility for predicting prolonged recovery. STUDY DESIGN: Observational. LEVEL OF EVIDENCE: Level 2. METHODS: A modified step test - an aerobic challenge of 3 to 6 minutes of stepping, targeting zone 2 heartrate (HR, defined as 60% to 70% of maximum HR for age) - assessed patients aged 8 to 18 years with concussion presenting to our concussion specialty program within /=3 concussion symptoms from baseline, or patient/parent request to stop), or (2) minor: symptom provocation but below early stopping criteria threshold. Multivariate modeling (1) assessed the odds of EI adjusting for relevant covariates, and (2) determined the influence of EI on prolonged recovery (time in clinical care >28 days), adjusting for factors with known associations with prolonged recovery. RESULTS: We included 578 patients. Overall, 366 patients (63%) met criteria for EI, with EI prevalence varying by sex, history of anxiety or depression, and initial symptom burden. In the fully adjusted model, female sex (odds ratio [OR], 1.9; 95% CI, 1.3-2.8), and initial visit symptom burden (OR, 1.05; 95% CI, 1.04-1.06) were associated with EI. Thirty percent of patients (n = 174) demonstrated prolonged recovery. In the multivariate model, major (OR, 1.8; 95% CI, 1.1-3.1) and minor (OR, 2.4; 95% CI, 1.4-4.1) EI were both associated with prolonged recovery. CONCLUSION: This study demonstrates feasibility of identifying EI in youth with concussion via a simple in-office modified step test and the relationship of this measure to prolonged recovery. CLINICAL RELEVANCE: These results have clinical utility for individualizing concussion recovery plans in ambulatory care outside of specialty care settings. FAU - Grady, Matthew F AU - Grady MF AD - Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, and Sports Medicine and Performance Center, Division of Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Fedonni, Daniele AU - Fedonni D AD - Department of Biomedical and Health Informatics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Wilkes, James AU - Wilkes J AUID- ORCID: 0000-0003-3402-7650 AD - Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Cobb, Justin AU - Cobb J AD - Sports Medicine and Performance Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Calandra, Lindsey AU - Calandra L AD - Sports Medicine and Performance Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Easby, Kate AU - Easby K AD - Sports Medicine and Performance Center, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Corwin, Daniel J AU - Corwin DJ AD - Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, and Division of Emergency Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Master, Christina L AU - Master CL AD - Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, and Sports Medicine and Performance Center, Division of Orthopedics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Arbogast, Kristy B AU - Arbogast KB AUID- ORCID: 0000-0002-1694-4562 AD - Center for Injury Research and Prevention, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, and Division of Emergency Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. LA - eng PT - Journal Article DEP - 20260907 PL - United States TA - Sports Health JT - Sports health JID - 101518422 SB - IM PMC - PMC13550243 OTO - NOTNLM OT - concussion OT - exercise OT - office assessment OT - pediatric EDAT- 2026/09/07 05:35 MHDA- 2026/09/07 05:35 PMCR- 2027/09/07 CRDT- 2026/09/07 04:26 PHST- 2026/09/07 05:35 [medline] PHST- 2026/09/07 05:35 [pubmed] PHST- 2026/09/07 04:26 [entrez] PHST- 2027/09/07 00:00 [pmc-release] AID - 10.1177_19417381261477255 [pii] AID - 10.1177/19417381261477255 [doi] PST - aheadofprint SO - Sports Health. 2026 Sep 7:19417381261477255. doi: 10.1177/19417381261477255. PMID- 42703382 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260908 IS - 1177-8881 (Electronic) IS - 1177-8881 (Linking) VI - 20 DP - 2026 TI - A Physiologically-Based Pharmacokinetic Model to Predict Posaconazole Suspension Exposure and Optimize Dosing Strategy in Pediatric Hematology Patients: Incorporating the Impact of Food Intake. PG - 632843 LID - 10.2147/DDDT.S632843 [doi] LID - 632843 AB - OBJECTIVE: This study aimed to develop and validate a physiologically based pharmacokinetic (PBPK) model for posaconazole oral suspension in pediatric hematology patients to predict systemic exposure and optimize dose regimens that incorporate food intake. METHODS: A PBPK model was established and validated in adults. The model was then extrapolated to pediatric patients by integrating age-specific physiological parameters. The pediatric model was validated using published data and local therapeutic drug monitoring results. The validated model was employed to simulate posaconazole exposure across different age groups, dosing regimens, and meal conditions. RESULTS: The adult PBPK model showed good predictability, with fold errors within 0.5-2.0 and a geometric mean fold error < 2.0. Sensitivity analysis identified the bile salt solubilization ratio, gastric pH, and hepatic UGT1A4 as critical determinants. The pediatric model accurately predicted plasma concentrations, with a mean absolute prediction error of 12.3%. Simulations revealed that achieving prophylactic trough concentration (C(min)) is challenging under fasted conditions, while fed administration significantly increases C(min)s. C(min)s increased with age and meal fat/calorie content, but no significant further increase was observed across all age groups beyond 6 mg/kg dose levels under fed conditions, with this plateau pattern consistent for both three- and four-times daily regimens. The oral suspension was unreliable in children aged < 2 years. In contrast, a high-fat, high-calorie meal was necessary for children aged 2-6 years, and a moderate-fat, moderate-calorie meal for those aged 7-12 years, whereas a low-fat, low-calorie meal was sufficient for those aged >/= 13 years. CONCLUSION: This study successfully developed and validated a PBPK model for posaconazole suspension in pediatric hematology patients, which could serve as a supportive in silico tool for model-informed dose optimization in this population. Further prospective clinical validation is still required to support its real-world dosing decision application. CI - (c) 2026 Wu et al. FAU - Wu, Juan AU - Wu J AUID- ORCID: 0000-0002-0792-5300 AD - Department of Pharmacy Administration, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Qin, Xia AU - Qin X AD - Blood and Marrow Transplantation Center, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Huang, Xiaohang AU - Huang X AUID- ORCID: 0009-0000-3530-3835 AD - Blood and Marrow Transplantation Center, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Wang, Dengyu AU - Wang D AD - Department of Pharmacy Administration, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Jin, Cheng AU - Jin C AD - Department of Pharmacy Administration, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Huang, Shiying AU - Huang S AD - Department of Pharmacy Administration, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Li, Zhuo AU - Li Z AD - Department of Pharmacy Administration, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. FAU - Liu, Manman AU - Liu M AD - Department of Pharmacy Administration, Shanghai Children's Medical Center, School of Medicine, Shanghai JiaoTong University, Shanghai, People's Republic of China. LA - eng PT - Journal Article DEP - 20260902 PL - New Zealand TA - Drug Des Devel Ther JT - Drug design, development and therapy JID - 101475745 RN - 0 (Triazoles) RN - 6TK1G07BHZ (posaconazole) RN - 0 (Suspensions) RN - 0 (Antifungal Agents) SB - IM MH - Humans MH - *Triazoles/pharmacokinetics/administration & dosage/blood MH - Child MH - *Models, Biological MH - Suspensions MH - Child, Preschool MH - Administration, Oral MH - Dose-Response Relationship, Drug MH - *Antifungal Agents/pharmacokinetics/administration & dosage MH - Adolescent MH - *Eating MH - Infant MH - Male MH - Female PMC - PMC13546638 OTO - NOTNLM OT - dose optimization OT - food intake OT - pediatrics OT - physiologically based pharmacokinetic model OT - posaconazole oral suspension COIS- The authors have no conflicts of interest to declare regarding the content of this article. EDAT- 2026/09/07 05:35 MHDA- 2026/09/07 05:36 PMCR- 2026/09/02 CRDT- 2026/09/07 04:02 PHST- 2026/06/14 00:00 [received] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/09/07 05:36 [medline] PHST- 2026/09/07 05:35 [pubmed] PHST- 2026/09/07 04:02 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - 632843 [pii] AID - 10.2147/DDDT.S632843 [doi] PST - epublish SO - Drug Des Devel Ther. 2026 Sep 2;20:632843. doi: 10.2147/DDDT.S632843. eCollection 2026. PMID- 42701327 OWN - NLM STAT- Publisher LR - 20260906 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 Sep 6 TI - Bringing the child's and parents' voices together: French validation of the SMU and STU quality of life questionnaires in pediatric obesity. PG - 2601060261484279 LID - 10.1177/02601060261484279 [doi] AB - BackgroundChildhood obesity is associated with significant impairments in health-related quality of life (HRQoL), yet culturally adapted, weight-specific tools are lacking in French-speaking settings.AimThis study aimed to validate French versions of the Sizing Me Up (SMU) and Sizing Them Up (STU) questionnaires to assess obesity-related quality of life in children and adolescents from self- and parent-report perspectives.MethodsShortened French versions of the SMU and STU were developed, retaining three subscales common to both instruments (Emotional, Physical, and Teasing/Marginalization) based on theoretical and psychometric criteria. A clinical sample included 120 children and adolescents with obesity (aged 5-18 years) and their parents. Psychometric analyses included internal consistency, confirmatory factor analysis, convergent validity with the Pediatric Quality of Life Inventory (PedsQL), sensitivity to body mass index (BMI) z-scores, measurement invariance across age and sex, and parent-child agreement.ResultsBoth instruments demonstrated good internal consistency and a stable three-factor structure. Associations were observed between the BMI z-score and the Physical domain, with modest effect sizes comparable to those of the generic PedsQL. Convergent validity was supported by correlations with corresponding PedsQL subscales. Measurement invariance held across age groups and for the SMU across sex, but the STU across sex did not achieve configural invariance. Procrustean analysis indicated moderate structural similarities between child and parent profiles, with moderate to good individual-level agreement, higher for physical than emotional domains.SummaryThe shortened French SMU and STU are reliable and valid tools for assessing HRQoL in pediatric obesity, supporting their use in clinical and research settings. FAU - Brodard, Fabrice AU - Brodard F AUID- ORCID: 0000-0002-3000-0891 AD - Family and Development Research Center, University of Lausanne, Lausanne, Switzerland. RINGGOLD: 27213 AD - Institute of Psychology, University of Lausanne, Lausanne, Switzerland. RINGGOLD: 27213 FAU - Antonietti, Jean-Philippe AU - Antonietti JP AUID- ORCID: 0000-0003-0117-4769 AD - Family and Development Research Center, University of Lausanne, Lausanne, Switzerland. RINGGOLD: 27213 FAU - Amouroux, Remy AU - Amouroux R AUID- ORCID: 0000-0003-3402-0942 AD - Family and Development Research Center, University of Lausanne, Lausanne, Switzerland. RINGGOLD: 27213 FAU - Bouthors, Therese AU - Bouthors T AD - Unit of Pediatric Endocrinology and Diabetology Unit, Service of Pediatrics, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland. RINGGOLD: 527885 FAU - Hauschild, Michael AU - Hauschild M AD - Unit of Pediatric Endocrinology and Diabetology Unit, Service of Pediatrics, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland. RINGGOLD: 527885 FAU - Ruiz Arana, Inge Lore AU - Ruiz Arana IL AD - Unit of Pediatric Endocrinology and Diabetology Unit, Service of Pediatrics, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland. RINGGOLD: 527885 FAU - Antoniou, Maria-Christina AU - Antoniou MC AUID- ORCID: 0000-0002-8089-7908 AD - Unit of Pediatric Endocrinology and Diabetology Unit, Service of Pediatrics, Woman-Mother-Child Department, Lausanne University Hospital, Lausanne, Switzerland. RINGGOLD: 527885 LA - eng PT - Journal Article DEP - 20260906 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - French translation OT - Pediatric obesity OT - SMU OT - STU OT - quality of life OT - questionnaire validation EDAT- 2026/09/06 05:40 MHDA- 2026/09/06 05:40 CRDT- 2026/09/06 03:23 PHST- 2026/09/06 05:40 [medline] PHST- 2026/09/06 05:40 [pubmed] PHST- 2026/09/06 03:23 [entrez] AID - 10.1177/02601060261484279 [doi] PST - aheadofprint SO - Nutr Health. 2026 Sep 6:2601060261484279. doi: 10.1177/02601060261484279. PMID- 42700485 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261008 IS - 1872-7123 (Electronic) IS - 0165-1781 (Linking) VI - 366 DP - 2026 Dec TI - Agreement between smartphone-based mobile sensing and actigraphy sleep metrics in young people with bipolar disorder. PG - 117434 LID - S0165-1781(26)00494-4 [pii] LID - 10.1016/j.psychres.2026.117434 [doi] AB - BACKGROUND: Sleep disturbance is a core feature of bipolar disorder (BD) and often precedes mood recurrence, particularly in youth. Smartphone-based mobile sensing offers a scalable alternative to objective sleep measurement via actigraphy, but its validity in youths with BD is unclear. METHODS: Analyses included adolescents and young adults (ages 14-25) with BD-I/II from the PROMPT-BD study with at least four days of concurrent actigraphy and mobile sensing. Actigraphy-derived sleep metrics were compared with smartphone-derived proxies. Agreement was evaluated using root mean squared error (RMSE) and mixed-effects models. Zero-inflated negative binomial models examined associations between actigraphy-derived and mobile-sensing derived wake after sleep onset (WASO). Sensitivity analyses tested robustness to missing data, smartphone use patterns, sleep window definitions, operating system, presence of mood symptoms and anxiety, and weekend effects. RESULTS: Mobile sensing showed strong convergence with actigraphy for sleep timing and duration. RMSEs were <21 minutes for onset, offset, midsleep, and TST, with strongest agreement for midsleep (RMSE = 14.8 minutes). Mobile sensing slightly overestimated sleep duration and estimated earlier timing, and underestimated WASO. Greater WASO significantly increased the odds of detecting any via mobile sensing; mobile sensing proxies were sensitive to the presence of nocturnal wakefulness but did not provide an accurate estimate of the extent of sleep fragmentation. Findings were robust across sensitivity analyses. CONCLUSIONS: Passive smartphone-derived sleep metrics approximated actigraphy-based estimates of sleep timing and duration in youth with BD. Given the widespread availability of smartphones in this population, this supports their potential as scalable tools for monitoring circadian disruption and informing early intervention. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Lopaczynski, Adrianna AU - Lopaczynski A AD - University of Pittsburgh Medical Center, Pittsburgh, USA. Electronic address: lopaczynskia2@upmc.edu. FAU - Merranko, John AU - Merranko J AD - University of Pittsburgh Medical Center, Pittsburgh, USA. FAU - Mak, Jessica AU - Mak J AD - University of Pittsburgh Medical Center, Pittsburgh, USA. FAU - Gill, Mary Kay AU - Gill MK AD - University of Pittsburgh Medical Center, Pittsburgh, USA. FAU - Goldstein, Tina R AU - Goldstein TR AD - University of Pittsburgh Medical Center, Pittsburgh, USA; University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, USA. FAU - Fedor, Jennifer AU - Fedor J AD - University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, USA. FAU - Low, Carissa AU - Low C AD - University of Pittsburgh School of Medicine, Department of Medicine, Pittsburgh, USA. FAU - Levenson, Jessica C AU - Levenson JC AD - University of Pittsburgh Medical Center, Pittsburgh, USA; University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, USA. FAU - Birmaher, Boris AU - Birmaher B AD - University of Pittsburgh Medical Center, Pittsburgh, USA; University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, USA. FAU - Hafeman, Danella M AU - Hafeman DM AD - University of Pittsburgh Medical Center, Pittsburgh, USA; University of Pittsburgh School of Medicine, Department of Psychiatry, Pittsburgh, USA. LA - eng PT - Journal Article DEP - 20260901 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 SB - IM UOF - medRxiv. 2026 Mar 02:2026.02.20.26346722. doi: 10.64898/2026.02.20.26346722. PMID: 41867203 MH - Humans MH - *Actigraphy/standards/methods MH - *Smartphone MH - *Bipolar Disorder/complications/physiopathology MH - Adolescent MH - Female MH - *Sleep Wake Disorders/diagnosis/etiology/physiopathology MH - Male MH - Young Adult MH - Adult MH - Sleep Duration MH - Sleep/physiology OTO - NOTNLM OT - Actigraphy OT - Adolescence OT - Bipolar disorder OT - Digital phenotyping OT - Mobile sensing OT - Mood recurrence OT - Sleep COIS- Declaration of competing interest The authors declare that they have no conflicts of interest related to this study. EDAT- 2026/09/06 01:18 MHDA- 2026/10/08 23:31 CRDT- 2026/09/05 18:00 PHST- 2026/03/19 00:00 [received] PHST- 2026/08/25 00:00 [revised] PHST- 2026/08/31 00:00 [accepted] PHST- 2026/10/08 23:31 [medline] PHST- 2026/09/06 01:18 [pubmed] PHST- 2026/09/05 18:00 [entrez] AID - S0165-1781(26)00494-4 [pii] AID - 10.1016/j.psychres.2026.117434 [doi] PST - ppublish SO - Psychiatry Res. 2026 Dec;366:117434. doi: 10.1016/j.psychres.2026.117434. Epub 2026 Sep 1. PMID- 42699094 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260905 LR - 20260907 IS - 2950-1334 (Electronic) IS - 2950-1334 (Linking) VI - 14 DP - 2026 Nov TI - Multimodality assessment of right ventricular-pulmonary arterial coupling and pulmonary artery compliance in youth with pulmonary arterial hypertension: A pilot study. PG - 100664 LID - 10.1016/j.jhlto.2026.100664 [doi] LID - 100664 AB - BACKGROUND: Cardiac magnetic resonance (CMR) enables comprehensive assessment of right ventricular (RV) function and ventricular-vascular interaction in pulmonary arterial hypertension (PAH). This exploratory pilot study compared echocardiographic and CMR-derived surrogate indices of RV-pulmonary arterial (RV-PA) coupling and examined indexed pulmonary artery compliance (PAc) in adolescents and young adults with PAH. METHODS: Twenty adolescents and young adults with Group 1 PAH underwent transthoracic echocardiography, CMR, and cardiac catheterization within 7 days. Echocardiographic TAPSE/systolic pulmonary artery pressure (sPAP) and CMR RV stroke volume/end-systolic volume were analyzed as noninvasive surrogates of RV-PA coupling; pressure-volume loop-derived end-systolic elastance/arterial elastance was not measured. Indexed PAc and pulmonary vascular resistance index (PVRi) were derived from catheterization and CMR data. Associations with WHO functional class, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and 6-minute walk distance (6MWD) were explored. RESULTS: Echocardiographic TAPSE/sPAP showed limited associations with clinical severity measures. CMR-derived RV indices showed stronger exploratory associations with NT-proBNP and 6MWD. In the prespecified multivariable model of the exercise endpoint, indexed PAc had the largest standardized coefficient (beta = -0.78; 95% CI, -1.48 to -0.09; p = 0.031); PVRi and the imaging surrogates were not statistically significant. Estimates were imprecise because of the small sample. CONCLUSIONS: In this small, hypothesis-generating cohort, CMR-derived RV-PA coupling and indexed PAc provided complementary physiologic information beyond the echocardiographic surrogate. These observations require validation against pressure-volume loop-derived coupling and prospective clinical outcomes. CI - (c) 2026 The Author(s). FAU - Raj, Shashi AU - Raj S AD - Clinical Lead, Pediatric & Adult CHD Heart Failure and Transplantation, Narayana Institute of Cardiac Sciences, Bangalore, India. FAU - Khan, Basha AU - Khan B AD - Program Director, Pulmonology & Lung Transplantation, Narayana Institute of Cardiac Sciences, Bangalore, India. FAU - Raj, Vimal AU - Raj V AD - Chief, Department of Cardiothoracic Radiology, Narayana Institute of Cardiac Sciences, Bangalore, India. FAU - Pulagam, Vamsidhar Reddy AU - Pulagam VR AD - Fellow, Department of Cardiothoracic Radiology, Narayana Institute of Cardiac Sciences, Bangalore, India. FAU - Das, Bibhuti B AU - Das BB AD - Pediatric Cardiology, Methodist Children's Hospital, San Antonio, Texas. LA - eng PT - Journal Article DEP - 20260815 PL - United States TA - JHLT Open JT - JHLT open JID - 9918716187806676 PMC - PMC13543909 OTO - NOTNLM OT - cardiac magnetic resonance imaging OT - pediatric pulmonary hypertension OT - pulmonary artery compliance OT - pulmonary vascular resistance OT - right ventricular-pulmonary arterial coupling COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/06 01:18 MHDA- 2026/09/06 01:19 PMCR- 2026/08/15 CRDT- 2026/09/05 09:14 PHST- 2026/09/06 01:19 [medline] PHST- 2026/09/06 01:18 [pubmed] PHST- 2026/09/05 09:14 [entrez] PHST- 2026/08/15 00:00 [pmc-release] AID - S2950-1334(26)00185-0 [pii] AID - 100664 [pii] AID - 10.1016/j.jhlto.2026.100664 [doi] PST - epublish SO - JHLT Open. 2026 Aug 15;14:100664. doi: 10.1016/j.jhlto.2026.100664. eCollection 2026 Nov. PMID- 42699031 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260905 LR - 20260907 IS - 2645-4904 (Electronic) IS - 2645-4904 (Linking) VI - 14 IP - 1 DP - 2026 TI - Shock-Stratified Prognostic Performance of Lactate and Procalcitonin in Pediatric Sepsis In-Hospital Mortality; A Retrospective Cohort Study. PG - e34 LID - 10.22037/aaem.v14i1.3029 [doi] LID - e34 AB - INTRODUCTION: Admission lactate and procalcitonin (PCT) are routinely measured in pediatric sepsis; however, their prognostic performance may vary by clinical phenotype. This study aimed to evaluate the shock-stratified prognostic performance of admission lactate and PCT for predicting in-hospital mortality in children with sepsis. METHODS: In this retrospective cohort study (July 2022 - July 2025), children aged 2 months to 15 years evaluated for suspected sepsis were screened; 193 met eligibility criteria and were included in analyses. Septic shock was recorded at admission, and organ dysfunction was recorded at admission or within the first 24 hours. The Phoenix Sepsis Score was calculated in 143 patients with complete lactate and other required data, whereas the Pediatric Sequential Organ Failure Assessment (pSOFA) score was calculated for all 193 patients using data recorded within the first 24 hours. Admission lactate and PCT were summarized by survival status within shock and non-shock phenotypes. Multivariable logistic regression models adjusted for age and malnutrition assessed biomarker-mortality associations and biomarker x shock interactions. Discrimination was evaluated using shock-stratified receiver operating characteristic (ROC) curves and area under the curve (AUC), with DeLong tests comparing AUCs between phenotypes. RESULTS: Among 193 children, 93 (48.2%) had septic shock, 145 (75.1%) had organ dysfunction, and 79 (40.9%) died in hospital. The median Phoenix Sepsis Score was 2.0 (range, 0--12) among 143 patients, while the median pSOFA score was 4.0 (range: 0--21) among all 193 patients. Mortality was higher in shock than non-shock sepsis (66.7% vs 17.0%; odds ratio (OR): 9.77 (95% confidence interval (CI): 4.96-19.24)) and in those with organ dysfunction (53.1% vs 4.2%; OR = 26.03 (95% CI: 6.09-111.34)). Admission lactate was higher in non-survivors than survivors in both non-shock and shock groups (p<0.05). In adjusted interaction models, each 1 mmol/L increase in lactate (OR = 1.50, 95% CI: 1.11--2.01; p = 0.0075) and each one-unit increase in natural-log--transformed PCT (ln(PCT)) (OR = 1.34, 95% CI: 1.01-1.79; p=0.0458) were associated with mortality in non-shock sepsis. The lactate x shock interaction (OR = 0.76, 95% CI: 0.55--1.05; p = 0.092) and ln(PCT) x shock interaction (OR = 0.74, 95% CI: 0.52--1.07; p = 0.114) were not statistically significant. Shock-stratified ROC curve analysis showed better discrimination in non-shock than shock for lactate (AUC: 0.76 (95% CI: 0.67-0.85) vs 0.62 (95% CI: 0.40-0.83); DeLong p=0.233) and modest discrimination for natural-log-transformed PCT [ln(PCT)] in both phenotypes (AUC: 0.65 (95% CI: 0.55-0.75) vs 0.61 (95% CI: 0.41-0.80); DeLong p=0.695). CONCLUSION: Admission lactate showed moderate discrimination for in-hospital mortality in non-shock sepsis, whereas discrimination was lower in septic shock. PCT showed modest discrimination across phenotypes. Although AUCs were numerically higher in non-shock sepsis, between-phenotype differences were not statistically significant, supporting phenotype-based interpretation and the need for external validation. FAU - Vo, Thi Van AU - Vo TV AD - Department of Pediatrics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam. FAU - Lu, Dien Tri AU - Lu DT AD - Department of General Nursing, Internal Medicine Program, Faculty of Nursing and Medical Technology, Can Tho University of Medicine and Pharmacy, Can Tho, Vietnam. FAU - Thai, Dien Minh AU - Thai DM AD - Faculty of Medicine, Nam Can Tho University, Can Tho, Vietnam. LA - eng PT - Journal Article DEP - 20260803 PL - Iran TA - Arch Acad Emerg Med JT - Archives of academic emergency medicine JID - 101740147 PMC - PMC13542529 OTO - NOTNLM OT - Biomarkers OT - Lactic acid OT - Pediatrics OT - Procalcitonin OT - Sepsis OT - Shock, septic COIS- The authors declare no conflict of interest. EDAT- 2026/09/06 01:18 MHDA- 2026/09/06 01:19 PMCR- 2026/08/03 CRDT- 2026/09/05 09:05 PHST- 2026/09/06 01:19 [medline] PHST- 2026/09/06 01:18 [pubmed] PHST- 2026/09/05 09:05 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.22037/aaem.v14i1.3029 [doi] PST - epublish SO - Arch Acad Emerg Med. 2026 Aug 3;14(1):e34. doi: 10.22037/aaem.v14i1.3029. eCollection 2026. PMID- 42697107 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261024 IS - 2211-0356 (Electronic) IS - 2211-0348 (Linking) VI - 115 DP - 2026 Nov TI - Longitudinal stability of dietary intake patterns in pediatric-onset multiple sclerosis: A multicenter prospective cohort study. PG - 107677 LID - S2211-0348(26)00712-1 [pii] LID - 10.1016/j.msard.2026.107677 [doi] AB - BACKGROUND: Diet may influence MS activity, but most studies use a single dietary measure. The stability of diet over time in pediatric-onset MS (POMS) is unclear. OBJECTIVES: To evaluate the reproducibility and short-term temporal stability of dietary intake in youth with POMS using repeated food frequency questionnaires (FFQ). METHODS: This longitudinal study included participants with a baseline FFQ (the Block Kids Food Screener, 2014). Intraclass correlation coefficients (ICCs) were estimated using random-intercept mixed-effects models to quantify the relative contributions of between-person and within-person variability. Temporal trends in intake were assessed by modeling time since baseline as a fixed effect, using log-transformed dietary variables to estimate percent change over time. RESULTS: Of 419 FFQs from 195 participants, 140 (71.8%) completed >/=2 FFQs over a median of 6.5 months (range 2.8-18). ICCs ranged from 0.41 to 0.78 across dietary measures, with the highest reproducibility observed for vegetables and fiber (ICCs 0.78 and 0.72). Log-transformed models showed small declines in several nutrients over time, corresponding to <10% change over a six-month period. CONCLUSIONS: Dietary intake demonstrated moderate to good reproducibility over the 6 to 18 month follow-up period. Vegetable and fiber intake had the strongest reliability. These findings suggest that reported dietary intake assessed by a single or infrequent FFQ may remain reasonably stable over a 6- to 18-month period in longitudinal POMS studies. However, the moderate-to-good reproducibility observed indicates that within-person variability persists and may attenuate diet-disease associations when only a single dietary assessment is available. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Virupakshaiah, Akash AU - Virupakshaiah A AD - UCSF School of Medicine, San Francisco, CA, USA. Electronic address: Akash.Virupakshaiah@ucsf.edu. FAU - Schoeps, Vinicius A AU - Schoeps VA AD - UCSF School of Medicine, San Francisco, CA, USA. FAU - Chang, Gina AU - Chang G AD - UCSF School of Medicine, San Francisco, CA, USA. FAU - Waltz, Michael AU - Waltz M AD - University of Utah, Salt Lake City, UT, USA. FAU - Race, Jonathan AU - Race J AD - University of Utah, Salt Lake City, UT, USA. FAU - Mar, Soe AU - Mar S AD - Washington University in St Louis School of Medicine, Department of Neurology, St. Louis, MO, USA. FAU - Francisco, Carla AU - Francisco C AD - UCSF School of Medicine, San Francisco, CA, USA. FAU - Casper, T Charles AU - Casper TC AD - University of Utah, Salt Lake City, UT, USA. FAU - Rose, John AU - Rose J AD - University of Utah, Salt Lake City, UT, USA. FAU - Rodriguez, Moses AU - Rodriguez M AD - Mayo Clinic, Rochester, MN, USA. FAU - Tillema, Jan-Mendelt AU - Tillema JM AD - Mayo Clinic, Rochester, MN, USA. FAU - Chitnis, Tanuja AU - Chitnis T AD - Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Gorman, Mark P AU - Gorman MP AD - Boston Children's Hospital, Boston, MA, USA. FAU - Benson, Leslie A AU - Benson LA AD - Boston Children's Hospital, Boston, MA, USA. FAU - Graves, Jennifer S AU - Graves JS AD - Department of Neurosciences, University of California, San Diego, CA, USA. FAU - Rensel, Mary AU - Rensel M AD - Cleveland Clinic, Cleveland, OH, USA. FAU - Abrams, Aaron AU - Abrams A AD - Cleveland Clinic, Cleveland, OH, USA. FAU - Krupp, Lauren B AU - Krupp LB AD - NYU Langone Health, NY, NY, USA. FAU - O'Neill, Kimberly A AU - O'Neill KA AD - NYU Langone Health, NY, NY, USA. FAU - Lotze, Timothy E AU - Lotze TE AD - Texas Children's Hospital, Houston, TX, USA. FAU - Aaen, Gregory AU - Aaen G AD - Loma Linda University Children's Hospital, Loma Linda, CA, USA. FAU - Wheeler, Yolanda AU - Wheeler Y AD - University of Alabama at Birmingham, Birmingham, AL, USA. FAU - Schreiner, Teri AU - Schreiner T AD - Children's Hospital Colorado, Denver, CO, USA. FAU - Waldman, Amy T AU - Waldman AT AD - Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Chong, Janet AU - Chong J AD - UCSF School of Medicine, San Francisco, CA, USA. FAU - Titcomb, Tyler J AU - Titcomb TJ AD - Department of Dietetics and Nutrition, University of Kansas Medical Center, United States. FAU - Tremlett, Helen AU - Tremlett H AD - Division of Neurology, Department of Medicine, The University of British Columbia, Canada. FAU - Waubant, Emmanuelle AU - Waubant E AD - UCSF School of Medicine, San Francisco, CA, USA. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260823 PL - Netherlands TA - Mult Scler Relat Disord JT - Multiple sclerosis and related disorders JID - 101580247 SB - IM MH - Humans MH - Female MH - Longitudinal Studies MH - Adolescent MH - Male MH - Child MH - Reproducibility of Results MH - *Multiple Sclerosis/epidemiology MH - *Diet MH - Prospective Studies MH - Diet Surveys MH - *Feeding Behavior MH - Age of Onset OTO - NOTNLM OT - Diet OT - Dietary assessment OT - Food frequency questionnaire OT - Pediatric-onset multiple sclerosis COIS- Declaration of competing interest None reported. EDAT- 2026/09/04 23:36 MHDA- 2026/10/24 05:34 CRDT- 2026/09/04 18:10 PHST- 2026/03/14 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/10/24 05:34 [medline] PHST- 2026/09/04 23:36 [pubmed] PHST- 2026/09/04 18:10 [entrez] AID - S2211-0348(26)00712-1 [pii] AID - 10.1016/j.msard.2026.107677 [doi] PST - ppublish SO - Mult Scler Relat Disord. 2026 Nov;115:107677. doi: 10.1016/j.msard.2026.107677. Epub 2026 Aug 23. PMID- 42695814 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260911 IS - 1364-6893 (Electronic) IS - 0144-3615 (Linking) VI - 46 IP - 1 DP - 2026 Dec TI - Predicting Category II and III foetal heart rate patterns during epidural analgesia: a retrospective cohort study. PG - 2721398 LID - 10.1080/01443615.2026.2721398 [doi] AB - BACKGROUND: This study aimed to identify predictors and develop a multivariable prediction model for Category II and III foetal heart rate (FHR) patterns in parturients undergoing labour epidural analgesia (LEA). METHODS: A retrospective cohort study of 237 parturients receiving LEA was conducted. To address the multicollinearity of 18 intrapartum variables, least absolute shrinkage and selection operator (LASSO) regression and cross-validation were used for feature selection. A predictive nomogram was constructed and internally validated. Model performance was evaluated by the area under the receiver operating characteristic curve (AUC), calibration plots, and Decision Curve Analysis (DCA). RESULTS: Abnormal FHR patterns (Category II and III) occurred in 168 (70.9%) parturients. The LASSO algorithm identified 11 predictors. Multivariable logistic regression demonstrated that maternal intrapartum temperature (OR = 3.518), initial LEA bolus count (OR = 3.625), body mass index (BMI), and oxytocin dosage were independent predictors associated with abnormal FHR patterns. The constructed nomogram demonstrated good discrimination (AUC = 0.800) and good calibration. DCA demonstrated potential clinical net benefit across a wide range of threshold probabilities (0.02-0.99). CONCLUSIONS: We developed and internally validated an 11-variable nomogram (AUC = 0.800) to predict abnormal FHR patterns during LEA. By integrating routinely available clinical variables, the nomogram facilitate early risk stratification and support individualised intrapartum management. TRIAL REGISTRATION: Clinical trial registration: (https://www.chictr.org.cn ChiCTR2300073493; registered 12th July 2023). FAU - Li, Bing AU - Li B AD - Jinan University, Guangzhou, Guangdong, China. AD - Department of Anesthesiology, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian Province. FAU - Wang, Qiqi AU - Wang Q AD - Department of Anesthesiology, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian Province. FAU - Xie, Yuemei AU - Xie Y AD - Department of Anesthesiology, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian Province. FAU - Chen, Liurong AU - Chen L AD - Department of Anesthesiology, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian Province. FAU - Jia, Junxiang AU - Jia J AD - Department of Anesthesiology, Department of Obstetrics and Gynecology, Women and Children's Hospital, School of Medicine, Xiamen University, Xiamen, Fujian Province. FAU - Song, Xingrong AU - Song X AD - Jinan University, Guangzhou, Guangdong, China. LA - eng PT - Journal Article DEP - 20260904 PL - England TA - J Obstet Gynaecol JT - Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology JID - 8309140 RN - 50-56-6 (Oxytocin) SB - IM MH - Adult MH - Female MH - Humans MH - Pregnancy MH - *Analgesia, Epidural/adverse effects/methods MH - *Analgesia, Obstetrical/adverse effects/methods MH - *Heart Rate, Fetal/physiology MH - Nomograms MH - Oxytocin/administration & dosage MH - Prediction Algorithms MH - Retrospective Studies MH - Cohort Studies OAB - Labour epidural analgesia is a safe and effective method of pain relief during childbirth. However, it can sometimes be accompanied by temporary changes in the baby's heart rate. At present, it is difficult for clinicians to identify in advance which mothers are more likely to develop these changes during labour.To address this question, we reviewed the medical records of 237 women who received labour epidural analgesia. Using statistical methods, we evaluated 18 clinical characteristics and identified 11 key predictors of abnormal foetal heart rate patterns. We found that a higher maternal temperature during labour, the need for additional epidural bolus doses shortly after analgesia, a higher body mass index (BMI), and greater oxytocin use were key predictive contributors associated with these heart rate changes.Based on these findings, we developed a simple risk prediction tool that may help clinicians identify women at increased risk earlier during labour. Earlier recognition of higher-risk patients may support closer monitoring and timely consideration of appropriate interventions, such as maternal repositioning, fluid administration, or adjustment of oxytocin when clinically indicated. Further studies are needed to determine whether use of this tool improves maternal and neonatal outcomes in routine clinical practice. OABL- eng OTO - NOTNLM OT - Epidural OT - analgesia OT - cardiotocography OT - foetus OT - nomogram OT - parturition EDAT- 2026/09/04 17:40 MHDA- 2026/09/04 17:41 CRDT- 2026/09/04 12:09 PHST- 2026/09/04 17:41 [medline] PHST- 2026/09/04 17:40 [pubmed] PHST- 2026/09/04 12:09 [entrez] AID - 10.1080/01443615.2026.2721398 [doi] PST - ppublish SO - J Obstet Gynaecol. 2026 Dec;46(1):2721398. doi: 10.1080/01443615.2026.2721398. Epub 2026 Sep 4. PMID- 42694496 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260923 IS - 2330-2941 (Electronic) IS - 2165-7971 (Print) IS - 2165-7971 (Linking) VI - 16 DP - 2026 TI - Parent Perspectives on Dietary and Nutraceutical Therapies in Autism Spectrum Disorder: A Qualitative Thematic Analysis Using a Large Language Model. PG - 17-30 LID - 10.14200/jrm.2026.0001 [doi] AB - OBJECTIVE: To explore how parents of children with autism spectrum disorder (ASD) implement dietary and nutraceutical therapies at home, and to understand the challenges, facilitators, and perceived outcomes that shape their use in real-world settings. DESIGN: A qualitative study using abductive thematic analysis to explore parent-reported experiences with implementing dietary and nutraceutical strategies for their children with ASD. SETTING: Remote interviews conducted with parents residing in Canada and the United States. PARTICIPANTS: A total of 10 semi-structured interviews were completed with 12 parents of children aged <18 years with ASD. Participants represented diverse regions, educational backgrounds, household structures, and linguistic environments. OUTCOME MEASURES: Parent perspectives on feasibility, decision-making processes, child responses, and perceived barriers or supports associated with dietary and nutraceutical strategies. RESULTS: Six themes were identified from parent interviews describing challenges in implementing dietary and nutraceutical interventions for children with ASD. These included parents as architects of care, in which caregivers assumed responsibility for researching, coordinating, and evaluating interventions; food as medicine and messenger, wherein behavioral and gastrointestinal responses served as real-time indicators of effectiveness; emotional weight and resilience, reflecting the psychological and practical burden experienced by caregivers; when systems fail, describing fragmented or insufficient medical guidance; compliance and the complexity of control, shaped by sensory sensitivities, rigid food preferences, family dynamics, and child autonomy; and rejection of one-size-fits-all solutions, emphasizing individualized, iterative approaches over standardized protocols. CONCLUSIONS: Parents face numerous sensory, emotional, and systemic challenges when attempting dietary and nutraceutical therapies for children with ASD. Greater clinical support and more individualized, evidence-informed guidance are needed to help families apply these strategies sustainably and determine which children are most likely to benefit. FAU - Baucum, Jaclyn AU - Baucum J AD - National University of Natural Medicine, Portland, OR, USA. FAU - Memauri, Tessa AU - Memauri T AD - University of Western States, Portland, OR, USA. FAU - Zwickey, Heather AU - Zwickey H AD - National University of Natural Medicine, Portland, OR, USA. AD - Helfgott Research Institute, National University of Natural Medicine, Portland, OR, USA. AD - Oregon Health and Sciences University, Portland, OR, USA. LA - eng GR - R25 DK130848/DK/NIDDK NIH HHS/United States GR - R90 AT008924/AT/NCCIH NIH HHS/United States GR - U24 AT012549/AT/NCCIH NIH HHS/United States PT - Journal Article DEP - 20260815 PL - United States TA - J Restor Med JT - Journal of restorative medicine JID - 101639173 PMC - PMC13539541 MID - NIHMS2204728 OTO - NOTNLM OT - Autism spectrum disorder OT - Diet, food, and nutrition OT - Large language models OT - Parents/guardians COIS- COMPETING INTERESTS The authors declare that they have no competing interests. EDAT- 2026/09/04 11:39 MHDA- 2026/09/04 11:40 PMCR- 2026/09/04 CRDT- 2026/09/04 09:03 PHST- 2026/09/04 11:40 [medline] PHST- 2026/09/04 11:39 [pubmed] PHST- 2026/09/04 09:03 [entrez] PHST- 2026/09/04 00:00 [pmc-release] AID - 10.14200/jrm.2026.0001 [doi] PST - ppublish SO - J Restor Med. 2026;16:17-30. doi: 10.14200/jrm.2026.0001. Epub 2026 Aug 15. PMID- 42693933 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261002 IS - 1367-4811 (Electronic) IS - 1367-4803 (Print) IS - 1367-4803 (Linking) VI - 42 IP - 9 DP - 2026 Aug 31 TI - Revealing subject-specific temporal patterns from longitudinal data. LID - 10.1093/bioinformatics/btag658 [doi] LID - btag658 AB - MOTIVATION: Temporal multivariate data are ubiquitous in many domains, for instance, being collected over time at planned visits (every few months/years) in longitudinal cohorts, or every few minutes/hours in challenge tests. The analysis of such data often focuses on revealing the underlying temporal patterns common across subjects. However, there are subject-specific differences in temporal patterns, which hold the promise to enhance our understanding of underlying mechanisms and facilitate personalized approaches. Nevertheless, extracting subject-specific temporal patterns from longitudinal multivariate data reliably is an open challenge. RESULTS: We introduce coupled matrix factorizations (CMFs) as effective tools to capture subject-specific temporal patterns focusing on two novel applications: analysis of longitudinal metabolomics data and sensitization data. Our analysis shows that CMF models reliably capture subject-specific (shape) differences in temporal patterns with the promise to reveal further insights compared to the state of the art. In metabolomics, CMF models reveal differences in metabolic responses of individuals (in a postprandial meal challenge) according to anthropometric and insulin sensitivity measures. In sensitization data analysis, CMF-based methods capture differences in temporal trajectories of children according to delivery/birth mode and atopic disease diagnosis. We demonstrate the reliability of extracted patterns using reproducibility and replicability. AVAILABILITY AND IMPLEMENTATION: The code is available on github.com/cchatzis/Revealing-Subject-specific-Temporal-Patterns-from-Longitudinal-Data and doi.org/10.5281/zenodo.22084338. Clinical data are not publicly available due to privacy reasons. Data can be made available under a joint research collaboration by contacting COPSAC (administration@dbac.dk). CI - (c) The Author(s) 2026. Published by Oxford University Press. FAU - Chatzis, Christos AU - Chatzis C AD - Department of Data Science and Knowledge Discovery, Simula Metropolitan Center for Digital Engineering, Oslo, 0170, Norway. AD - Faculty of Technology, Art and Design, Oslo Metropolitan University, Oslo, 0166, Norway. FAU - Horner, David AU - Horner D AUID- ORCID: 0000-0002-0200-4561 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820, Denmark. FAU - Bro, Rasmus AU - Bro R AD - Department of Food Science, University of Copenhagen, Copenhagen, 1958, Denmark. FAU - Schoos, Ann-Marie Malby AU - Schoos AM AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820, Denmark. AD - Department of Pediatrics, Copenhagen University Hospital-Naestved, Slagelse and Ringsted, Slagelse, 4200, Denmark. AD - Department of Pediatrics, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, 2650, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, 2200, Denmark. FAU - Rasmussen, Morten A AU - Rasmussen MA AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, 2820, Denmark. AD - Department of Food Science, University of Copenhagen, Copenhagen, 1958, Denmark. FAU - Acar, Evrim AU - Acar E AUID- ORCID: 0000-0002-3737-292X AD - Department of Data Science and Knowledge Discovery, Simula Metropolitan Center for Digital Engineering, Oslo, 0170, Norway. LA - eng GR - NNF23SA0087869/Novo Nordisk Foundation/ PT - Journal Article PL - England TA - Bioinformatics JT - Bioinformatics (Oxford, England) JID - 9808944 SB - IM MH - Humans MH - *Metabolomics/methods MH - Longitudinal Studies MH - Algorithms MH - *Computational Biology/methods PMC - PMC13623513 COIS- Ann-Marie Malby Schoos has received payment as a speaker from Thermo Fisher Scientific. EDAT- 2026/09/04 05:35 MHDA- 2026/09/30 05:30 PMCR- 2026/09/04 CRDT- 2026/09/04 04:13 PHST- 2026/01/30 00:00 [received] PHST- 2026/07/27 00:00 [revised] PHST- 2026/08/18 00:00 [accepted] PHST- 2026/09/30 05:30 [medline] PHST- 2026/09/04 05:35 [pubmed] PHST- 2026/09/04 04:13 [entrez] PHST- 2026/09/04 00:00 [pmc-release] AID - 8785290 [pii] AID - btag658 [pii] AID - 10.1093/bioinformatics/btag658 [doi] PST - ppublish SO - Bioinformatics. 2026 Aug 31;42(9):btag658. doi: 10.1093/bioinformatics/btag658. PMID- 42693541 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260914 IS - 1478-5153 (Electronic) IS - 1362-1017 (Print) IS - 1362-1017 (Linking) VI - 31 IP - 5 DP - 2026 Sep TI - Wearable Sleep and Circadian Monitoring in Intensive Care Nursing: A Scoping Review. PG - e70671 LID - 10.1111/nicc.70671 [doi] LID - e70671 AB - BACKGROUND: Sleep and circadian disruption are common in critical illness, yet bedside assessment remains difficult. Wearables are unobtrusive and extend observation across 24 h, but their measurement performance in critical illness requires appraisal. AIMS: To map wearable sleep and circadian monitoring during intensive care, its measurement performance, clinical applications and nursing implications. STUDY DESIGN: A scoping review followed JBI and PRISMA-ScR guidance. PubMed, Europe PMC and OpenAlex were searched from inception to 22 July 2026, with citation searching. Eligible primary reports used a body-worn sensor during intensive care to estimate sleep or circadian/rest-activity outcomes at any age. Conventional polysomnography/electroencephalography without an eligible wearable, non-contact systems, staff studies and post-ICU-only monitoring were excluded. No risk-of-bias appraisal was undertaken. RESULTS: Sixty-one reports (43 adult; 18 paediatric/neonatal; 1996-2026) were included. Actigraphy dominated; commercial trackers, smartwatches and one respiratory-belt/heart-rate-variability system were less common. Monitoring was feasible, but performance varied by device, patient state and age group: wake specificity was often poor in ventilated, sedated or immobile patients and agreement with patient or nurse reports was weak to modest. Records showed fragmented and daytime sleep, weak day-night consolidation and attenuated circadian rhythmicity. Nursing bundles, massage, positioning, light and chronotype-informed care changed selected outcomes, but effects were heterogeneous. CONCLUSIONS: Wearables usefully describe rest-activity patterns and support nursing assessment, but agreement with physiological sleep varied by device, patient state and age; movement-derived estimates need clinical context and are not a stand-alone sleep measure. RELEVANCE TO CLINICAL PRACTICE: Nurses should combine wearable trends with patient report, sedation and mobility, delirium screening and care-interaction records; escalation thresholds require prospective validation. CI - (c) 2026 British Association of Critical Care Nurses. FAU - Badawy, Walaa AU - Badawy W AUID- ORCID: 0000-0002-8154-0038 AD - College of Education, King Khalid University, Abha, Saudi Arabia. FAU - Shaban, Mostafa AU - Shaban M AUID- ORCID: 0000-0001-7822-1653 AD - Community Health Nursing Department, College of Nursing, Jouf University, Sakaka, Saudi Arabia. LA - eng GR - RGP2/129/47/Deanship of Research and Graduate Studies at King Khalid University/ PT - Journal Article PT - Scoping Review PL - England TA - Nurs Crit Care JT - Nursing in critical care JID - 9808649 SB - IM MH - Humans MH - *Critical Care Nursing MH - *Wearable Electronic Devices MH - *Sleep/physiology MH - *Circadian Rhythm/physiology MH - Monitoring, Physiologic/instrumentation MH - Actigraphy MH - Polysomnography MH - Intensive Care Units MH - Critical Illness PMC - PMC13542315 OTO - NOTNLM OT - actigraphy OT - circadian rhythm OT - critical care nursing OT - intensive care units OT - sleep monitoring COIS- The authors declare no conflicts of interest. EDAT- 2026/09/04 05:36 MHDA- 2026/09/04 05:37 PMCR- 2026/09/04 CRDT- 2026/09/04 01:50 PHST- 2026/08/15 00:00 [revised] PHST- 2026/07/23 00:00 [received] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/09/04 05:37 [medline] PHST- 2026/09/04 05:36 [pubmed] PHST- 2026/09/04 01:50 [entrez] PHST- 2026/09/04 00:00 [pmc-release] AID - NICC70671 [pii] AID - 10.1111/nicc.70671 [doi] PST - ppublish SO - Nurs Crit Care. 2026 Sep;31(5):e70671. doi: 10.1111/nicc.70671. PMID- 42692871 OWN - NLM STAT- Publisher LR - 20260903 IS - 1878-4046 (Electronic) IS - 1076-6332 (Linking) DP - 2026 Sep 3 TI - Value of the Newly Designed Major and Minor Checklists in Diagnosis of Congenital Cardiovascular Disease and Associated Malformation: New Era of Fetal Cardiac MRI. LID - S1076-6332(26)00583-0 [pii] LID - 10.1016/j.acra.2026.07.071 [doi] AB - RATIONALE AND OBJECTIVES: Fetal echocardiography is the standard, rapid, affordable, and noninvasive modality for prenatal assessment of suspected congenital heart disease. Fetal cardiac magnetic resonance imaging (FCMRI) has emerged as a valuable adjunct, particularly when ultrasound is limited by maternal obesity, uterine fibroids, oligohydramnios, fetal malposition, or late-gestational acoustic shadowing. Consequently, this study aimed to evaluate the diagnostic utility of a newly proposed structured major/minor checklist system for FCMRI interpretation. By correlating structured FCMRI interpretations with postnatal echocardiographic outcomes, we assess the framework's reliability in characterizing structural cardiovascular anomalies, particularly when initial ultrasound evaluation is suboptimal. MATERIALS AND METHODS: Between May 2024 and November 2025, an initial cohort of 60 pregnant women was screened, yielding 52 singleton pregnancies with suspected fetal cardiac anomalies. These cases were prospectively evaluated with fetal echocardiography and FCMRI. Image interpretation was performed by two radiologists experienced in prenatal imaging and one pediatric cardiologist. Postnatal confirmation was available for 40 live-born infants; 12 intrauterine fetal death cases were excluded from postnatal diagnostic-performance analysis. RESULTS: Based on postnatal echocardiography, both modalities demonstrated high diagnostic performance. Fetal echocardiography yielded slightly higher sensitivity than FCMRI (96.5% vs. 93.1%), whereas FCMRI exhibited higher specificity (100% vs. 81.8%) and overall diagnostic accuracy (95.0% vs. 92.5%). Notably, FCMRI demonstrated a significantly higher overall concordance with postnatal echocardiography compared to fetal echocardiography for ductus-dependent critical lesions (90.0% vs. 77.5% total agreement). This superior concordance for FCMRI was particularly pronounced in identifying emergency ductus-dependent lesions (72.7% vs. 36.4% agreement in positive cases), alongside higher exact concordance in normal, conotruncal, and hypoplastic heart-spectrum categories, whereas fetal echocardiography showed higher concordance in tetralogy of Fallot and Ebstein anomaly. Both modalities showed similar concordance for atrioventricular septal defects. CONCLUSION: FCMRI is a useful complementary adjunct to fetal echocardiography, improving diagnostic confidence in complex cases and supporting prenatal counseling, delivery planning, and postnatal management. CI - Copyright (c) 2026 The Association of University Radiologists. Published by Elsevier Inc. All rights reserved. FAU - Hassan, Hend Galal Eldeen Mohamed Ali AU - Hassan HGEMA AD - Department of Diagnostic, Interventional Radiology and Molecular Imaging, Faculty of Medicine, Ain Shams University, Cairo, Egypt. FAU - Ragheb, Samar Ramzy AU - Ragheb SR AD - Department of Diagnostic, Interventional Radiology and Molecular Imaging, Faculty of Medicine, Ain Shams University, Cairo, Egypt. FAU - Elyasaki, Ahmed M AU - Elyasaki AM AD - Technology of Prosthetic & Orthotic Devices Program, Faculty of Applied Health Sciences, Galala University, Suez, Egypt; Rheumatology, Rehabilitation and Physical Medicine Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. FAU - M M Habeeb, Nevin AU - M M Habeeb N AD - Pediatric Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt. FAU - G Khattap, Mohamed AU - G Khattap M AD - Technology of Radiology and Medical Imaging Program, Faculty of Applied Health Sciences Technology, Galala University, Suez 435611, Egypt. Electronic address: mohamed.khattap.2016@gmail.com. LA - eng PT - Journal Article DEP - 20260903 PL - United States TA - Acad Radiol JT - Academic radiology JID - 9440159 SB - IM OTO - NOTNLM OT - Congenital heart disease OT - Disease-spectrum classification OT - Fetal cardiac MRI OT - Fetal echocardiography OT - Major and minor checklists COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/09/03 23:36 MHDA- 2026/09/03 23:36 CRDT- 2026/09/03 21:52 PHST- 2026/05/27 00:00 [received] PHST- 2026/07/19 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/09/03 23:36 [medline] PHST- 2026/09/03 23:36 [pubmed] PHST- 2026/09/03 21:52 [entrez] AID - S1076-6332(26)00583-0 [pii] AID - 10.1016/j.acra.2026.07.071 [doi] PST - aheadofprint SO - Acad Radiol. 2026 Sep 3:S1076-6332(26)00583-0. doi: 10.1016/j.acra.2026.07.071. PMID- 42692055 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260911 IS - 1873-4030 (Electronic) IS - 1350-4533 (Linking) VI - 147 IP - 9 DP - 2026 Sep 11 TI - Anthropometry-aware chest-worn inertial sensing for pediatric activity assessment using a school-badge device. LID - 10.1088/1873-4030/aea226 [doi] AB - Objective assessment of physical activity in children and adolescents supports school health surveillance and the evaluation of behavioral interventions, but wearable recognition models are typically developed on adults, public benchmarks, or sample-level data splits that do not test performance on new users. Baseline models also encode the inertial stream alone and carry no description of the individual, leaving developmental differences in body size and movement execution uncorrected. This study developed the Anthropometry-Aware Temporal Attention DeepConvLSTM (AATA-DeepConvLSTM) model for single-label 22-class activity recognition from a chest-worn school-badge inertial measurement unit. It combines convolutional-recurrent encoding of eight inertial channels (triaxial acceleration and angular velocity at 100 Hz plus their magnitudes), temporal attention pooling, and representation-level fusion of age, sex, height, body weight, and body mass index as subject-level context. After quality control, 4,666 activity records from 128 participants aged 5-18 years were analyzed under subject-independent five-fold cross-validation, with record-level macro-averaged1 (Macro-1) as the primary metric. AATA-DeepConvLSTM reached a record-level accuracy of 0.9377 and a Macro-1 of 0.9291, against 0.9092 and 0.8992 for the strongest baseline, DeepConvLSTM. In ablation, temporal attention alone raised Macro-1 from 0.8992 to 0.9112 and real anthropometric context raised it to 0.9291, whereas shuffling the anthropometric values across participants returned it to 0.9117; height alone recovered 0.9264. Static postures remained the weakest classes. These results support anthropometry-aware wearable-signal modeling as a feasible engineering approach for pediatric activity assessment, while naturalistic validation and stable calibration protocols remain necessary before routine school-based deployment. CI - (c) 2026 Institute of Physics and Engineering in Medicine. All rights, including for text and data mining, AI training, and similar technologies, are reserved. FAU - Yang, Zhiyuan AU - Yang Z AUID- ORCID: 0009-0008-1495-4784 AD - Tianjin University of Sport, Tianjin, People's Republic of China. FAU - Li, Liang AU - Li L AD - China Institute of Sport Science, Beijing, People's Republic of China. FAU - Cai, Yujun AU - Cai Y AUID- ORCID: 0009-0003-6827-6708 AD - Shanghai University of Sport, Shanghai, People's Republic of China. FAU - Sun, Zhiyuan AU - Sun Z AD - Shandong Sport University, Jinan, People's Republic of China. FAU - Tao, Liangze AU - Tao L AD - School of Automation, Southeast University, Nanjing, People's Republic of China. FAU - Bao, Chunyu AU - Bao C AD - Tianjin University of Sport, Tianjin, People's Republic of China. FAU - Meng, Qinghua AU - Meng Q AD - Tianjin University of Sport, Tianjin, People's Republic of China. FAU - Li, Xuesong AU - Li X AD - Qufu Normal University, Qufu, People's Republic of China. FAU - Xue, Yijia AU - Xue Y AD - Tianjin University of Sport, Tianjin, People's Republic of China. FAU - Xiong, Kai AU - Xiong K AD - Zhongyuan University of Technology, Zhengzhou, People's Republic of China. FAU - Yan, Longxin AU - Yan L AD - Zhongyuan University of Technology, Zhengzhou, People's Republic of China. FAU - Bu, Can AU - Bu C AD - School of Automation, Southeast University, Nanjing, People's Republic of China. LA - eng PT - Journal Article DEP - 20260911 PL - England TA - Med Eng Phys JT - Medical engineering & physics JID - 9422753 SB - IM MH - Humans MH - Child MH - Adolescent MH - *Wearable Electronic Devices MH - Male MH - Female MH - *Anthropometry/instrumentation MH - Child, Preschool MH - *Schools MH - *Accelerometry/instrumentation OTO - NOTNLM OT - anthropometric information OT - biomedical engineering OT - few-shot personalization OT - human activity recognition OT - pediatric activity assessment OT - subject-independent validation OT - wearable inertial sensing EDAT- 2026/09/03 23:36 MHDA- 2026/09/11 17:36 CRDT- 2026/09/03 18:53 PHST- 2026/06/24 00:00 [received] PHST- 2026/09/03 00:00 [accepted] PHST- 2026/09/11 17:36 [medline] PHST- 2026/09/03 23:36 [pubmed] PHST- 2026/09/03 18:53 [entrez] AID - 10.1088/1873-4030/aea226 [doi] PST - epublish SO - Med Eng Phys. 2026 Sep 11;147(9). doi: 10.1088/1873-4030/aea226. PMID- 42690852 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260905 IS - 0971-5916 (Print) IS - 0971-5916 (Linking) VI - 164 IP - 3 DP - 2026 Sep TI - Body composition changes and nutritional challenges in children with acute lymphoblastic leukaemia: Perspectives from low-resource settings. PG - 435-444 LID - 10.25259/IJMR_3730_2025 [pii] AB - Acute lymphoblastic leukaemia (ALL) is the most common childhood cancer in India; despite improving survival in low-and middle-income countries (LMICs), outcomes remain inferior to those in high-income countries and are further complicated by the dual burden of undernutrition and treatment-related obesity. This narrative review synthesises evidence on nutritional status, body composition changes, and related challenges in children with ALL in low-resource settings, focusing on India. During treatment, weight and body mass index (BMI) may fluctuate, yet body-composition studies indicate that even when weight/BMI are stable or increase, lean mass can decline with concurrent fat gain. These alterations often persist into survivorship, increasing cardiometabolic and functional risks, highlighting the limitations of relying solely on anthropometric measurements, which may miss clinically important shifts in body composition. This issue is particularly relevant in South Asian children, who exhibit a 'thin fat' phenotype with relatively greater adiposity at a given BMI. Both undernutrition and overnutrition are associated with higher infection rates, chemotherapy toxicity, treatment delays, relapses, and mortality, yet nutritional care often remains peripheral within oncology services in LMICs. This review outlines the limitations of conventional anthropometry, summarises the feasibility and constraints of available body-composition techniques, and describes complementary biochemical, clinical, and dietary indicators to refine nutritional risk stratification. It also discusses health-system, socioeconomic, and cultural barriers, including gaps in caregiver nutrition knowledge. Collectively, the findings highlight the need to integrate routine nutrition screening, longitudinal body-composition monitoring, and individualised, culturally sensitive dietary interventions into standard paediatric ALL care, particularly in resource-limited settings. FAU - Puttaswamy, Deepa AU - Puttaswamy D AD - Manipal Academy of Higher Education (MAHE), Manipal, India. AD - Division of Nutrition, St. John's Research Institute, Bengaluru, Karnataka, India. FAU - Kuriyan, Rebecca AU - Kuriyan R AD - Division of Nutrition, St. John's Research Institute, Bengaluru, Karnataka, India. AD - Department of Physiology, St. John's Medical College, St. John's National Academy of Health Sciences, Bengaluru, Karnataka, India. LA - eng PT - Journal Article PT - Review PL - United States TA - Indian J Med Res JT - The Indian journal of medical research JID - 0374701 SB - IM MH - Humans MH - *Body Composition/physiology MH - *Precursor Cell Lymphoblastic Leukemia-Lymphoma/epidemiology/physiopathology/complications/pathology MH - Child MH - Resource-Limited Settings MH - *Nutritional Status MH - India/epidemiology MH - Body Mass Index MH - *Obesity/epidemiology/physiopathology MH - *Malnutrition/epidemiology/physiopathology PMC - PMC13541148 OTO - NOTNLM OT - Acute lymphoblastic leukaemia OT - Body composition OT - India OT - Nutritional status OT - Paediatric COIS- None. EDAT- 2026/09/03 17:36 MHDA- 2026/09/03 17:37 PMCR- 2026/09/01 CRDT- 2026/09/03 13:00 PHST- 2025/12/31 00:00 [received] PHST- 2026/02/26 00:00 [accepted] PHST- 2026/09/03 17:37 [medline] PHST- 2026/09/03 17:36 [pubmed] PHST- 2026/09/03 13:00 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - 10.25259/IJMR_3730_2025 [pii] AID - 10.25259/IJMR_3730_2025 [doi] PST - ppublish SO - Indian J Med Res. 2026 Sep;164(3):435-444. doi: 10.25259/IJMR_3730_2025. PMID- 42690225 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260906 IS - 1550-2783 (Electronic) IS - 1550-2783 (Linking) VI - 23 IP - 1 DP - 2026 Dec 30 TI - Assessment of energy cost in three winter sports: Alpine skiing, snowboarding, and simulated cross-country skiing. PG - 2722536 LID - 10.1080/15502783.2026.2722536 [doi] LID - 2722536 AB - BACKGROUND: Little is known about the energy costs of recreational skiing, snowboarding, and cross-country skiing activities in young adults. Investigating the intensity of such activities for promoting skiing in public health and exercise contexts is needed. This study measured the heart rate (HR), oxygen uptake (VO(2)), and respiratory quotient (RQ) of recreational Alpine skiing, snowboarding, and simulated cross-country skiing (roller skiing) in young adults (17-25 y). METHODS: Three cross-sectional studies were performed. Alpine skiing (study 1, n = 13, 11 males, 2 females) and snowboarding (study 2, n = 13, all males) were performed on a ski slope rated intermediate in difficulty. Each skier completed one run and was guided by a researcher to maintain a common speed. Simulated cross-country skiing (study 3, n = 13, 8 males, 5 females) was performed while the roller skiing on a laboratory treadmill at 0% incline with increasing velocities per stage. Two trials were conducted: free skate (combined V1, V2) and the classic technique. HR was monitored by telemetry. VO(2) and RQ were measured by portable indirect calorimetry. METs were computed as VO(2) ml.kg(-1.)min(-1) divided by 3.5. RESULTS: The energy cost in METS for men and women combined was highest for simulated cross-country skiing (free skate, 10.57 +/- 0.53; classic, 8.62 +/- 0.75) than Alpine skiing (7.76 +/- 1.18) and snowboarding (7.38 +/- 2.55). RQ was highest for Alpine skiing (0.96 +/- 0.10) than other skiing modes (on average, 0.87 to 0.88). Exercise HR was higher in the free skate (164.52 +/- 13.58) and Alpine skiing (153.41 +/- 20.54) than classic skiing (149.56 +/- 12.68) and snowboarding (139.39 +/- 41.96). CONCLUSIONS: Recreational Alpine skiing, snowboarding, and simulated cross-country skiing are vigorous-intensity activities with an energy cost exceeding 6 METs in young adults. This study provides empirical, protocol-specific MET values for these activities, which validated and refined the existing estimates for these activities in the Adult Compendium of Physical Activities, offering an empirical basis for more precise energy expenditure assessment in recreational skiing. FAU - Li, Lu AU - Li L AUID- ORCID: 0000-0001-5128-5323 AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Liang, Zhiqiang AU - Liang Z AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Sun, Bo AU - Sun B AD - School of Physical Education, Liaocheng University, Liaocheng, China. FAU - Yun, Chu AU - Yun C AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Ainsworth, Barbara E AU - Ainsworth BE AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Liu, Yu AU - Liu Y AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. AD - Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai, China. LA - eng PT - Journal Article DEP - 20260903 PL - United States TA - J Int Soc Sports Nutr JT - Journal of the International Society of Sports Nutrition JID - 101234168 SB - IM MH - Humans MH - *Skiing/physiology MH - *Energy Metabolism MH - Female MH - Heart Rate MH - Oxygen Consumption MH - Male MH - Young Adult MH - Cross-Sectional Studies MH - Adolescent MH - Adult PMC - PMC13543838 OTO - NOTNLM OT - METs OT - Olympic sports OT - energy costs OT - physical activity OT - winter sports COIS- No potential conflict of interest was reported by the author(s). EDAT- 2026/09/03 17:36 MHDA- 2026/09/03 17:37 PMCR- 2026/09/03 CRDT- 2026/09/03 12:19 PHST- 2026/09/03 17:37 [medline] PHST- 2026/09/03 17:36 [pubmed] PHST- 2026/09/03 12:19 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - 2722536 [pii] AID - 10.1080/15502783.2026.2722536 [doi] PST - ppublish SO - J Int Soc Sports Nutr. 2026 Dec 30;23(1):2722536. doi: 10.1080/15502783.2026.2722536. Epub 2026 Sep 3. PMID- 42690115 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260903 IS - 2035-648X (Electronic) IS - 1591-996X (Linking) VI - 27 IP - 3 DP - 2026 Sep 1 TI - Implementation and preliminary educational outcomes of a schoolbased peer-led oral health program in primary school children: A Pilot Study. PG - 211-218 LID - 10.23804/ejpd.2026.2801 [doi] AB - This pilot study aimed to describe the implementation of a school-based peer-led oral health education program in primary school children and to explore its feasibility and preliminary educational outcomes. The program was implemented in an international primary school and involved third- and fourth-grade students aged 7-9 years. After parental informed consent was obtained, baseline assessments were performed using questionnaires investigating oral health knowledge, oral hygiene habits, dietary behaviors, and previous dental experiences. Plaque-disclosing tablets were also used as a visual awareness tool. Fourth-grade students received a 3-hour training session delivered by a dental hygienist and subsequently conducted peer-led educational activities for third-grade students through five interactive learning stations. Follow-up assessments were carried out approximately 2 weeks and 5 months after the intervention. All educational materials were independently produced and designed to be easily reproducible in school settings. At the 5-month follow-up, most participants showed an improvement in oral health knowledge compared with baseline. Overall, 87.5% of children improved their knowledge scores, 75% reported improvements in oral hygiene and dietary habits, and 59.4% showed improvement in a derived home oral hygiene score based on questionnaire responses. In addition, the proportion of children reporting no gingival bleeding increased compared with baseline. Although limited by the small sample size, the single-school setting, the lack of a control group, and the reliance on questionnaire-based outcomes, this pilot study suggests that a peer-led school-based oral health program is feasible and may support improvements in children's oral health knowledge and self-reported habits. Larger controlled studies are needed to evaluate effectiveness and long-term sustainability. FAU - Maspero, C AU - Maspero C AD - Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy - Department of Biomedical, Surgical and Dental Sciences, School of Dentistry, University of Milan, Milan, Italy. FAU - Giannini, L AU - Giannini L AD - Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy. FAU - Inchingolo, A M AU - Inchingolo AM AD - Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy. FAU - Cressoni, C AU - Cressoni C AD - Department of Biomedical, Surgical and Dental Sciences, School of Dentistry, University of Milan, Milan, Italy. FAU - Esposito, L AU - Esposito L AD - Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy - Department of Biomedical, Surgical and Dental Sciences, School of Dentistry, University of Milan, Milan, Italy. FAU - Dini, C AU - Dini C AD - Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy. FAU - Di Iasio, G AU - Di Iasio G AD - Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy - Department of Biomedical, Surgical and Dental Sciences, School of Dentistry, University of Milan, Milan, Italy. FAU - Mauri, M A AU - Mauri MA AD - Department of Biomedical, Surgical and Dental Sciences, School of Dentistry, University of Milan, Milan, Italy. FAU - Macri, F AU - Macri F AD - Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico, Milan, Italy. FAU - Palermo, A AU - Palermo A AD - University of Salento, 73100 Lecce, Italy. FAU - Inchingolo, F AU - Inchingolo F AD - Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy. FAU - Calo, F AU - Calo F AD - Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy. FAU - Inchingolo, A D AU - Inchingolo AD AD - Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy. FAU - Dipalma, G AU - Dipalma G AD - Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy. LA - eng PT - Journal Article PL - Italy TA - Eur J Paediatr Dent JT - European journal of paediatric dentistry JID - 101121881 SB - IM MH - Humans MH - Pilot Projects MH - Child MH - *Peer Group MH - Female MH - *Health Education, Dental/methods MH - Male MH - Oral Hygiene/education MH - *Oral Health/education MH - Surveys and Questionnaires MH - Feasibility Studies MH - Health Knowledge, Attitudes, Practice MH - Program Evaluation EDAT- 2026/09/03 17:36 MHDA- 2026/09/03 17:37 CRDT- 2026/09/03 12:01 PHST- 2026/09/03 17:37 [medline] PHST- 2026/09/03 17:36 [pubmed] PHST- 2026/09/03 12:01 [entrez] AID - 10.23804/ejpd.2026.2801 [doi] PST - ppublish SO - Eur J Paediatr Dent. 2026 Sep 1;27(3):211-218. doi: 10.23804/ejpd.2026.2801. PMID- 42689895 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260903 IS - 1759-7390 (Electronic) IS - 1750-8460 (Linking) VI - 87 IP - 8 DP - 2026 Aug 12 TI - Association Between Insulin Resistance and Serum 25-Hydroxyvitamin D, Insulin-Like Growth Factor-1, and Blood Lipid Profiles in Children With Obesity. PG - 56972 LID - 10.31083/BJHM56972 [doi] AB - AIMS/BACKGROUND: Obesity in children was associated with insulin resistance (IR) and is often accompanied by dyslipidemia. 25-hydroxyvitamin D (25-(OH)D) and insulin-like growth factor-1 (IGF-1) have been implicated in IR. The purpose of this study was to explore the correlation between IR and serum 25-(OH)D, IGF-1, and blood lipid profiles in children with obesity. METHODS: A total of 125 children with obesity who attended The Affiliated Yangming Hospital of Ningbo University between January 2023 and April 2025 were retrospectively analyzed. According to insulin sensitivity, participants were divided into two groups: the insulin-sensitive group (n = 56, Homeostasis Model Assessment of Insulin Resistance [HOMA-IR] <3.16) and the insulin-resistant group (n = 69, HOMA-IR >/=3.16). Serum 25-(OH)D, IGF-1, and lipid profiles [triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C)] were measured. Binary logistic regression analysis and receiver operating characteristic (ROC) analyses were performed to investigate the association between IR and these biomarkers. RESULTS: Fasting insulin and HOMA-IR levels were significantly higher in the insulin-resistant group than in the insulin-sensitive group (p < 0.001). Compared with the insulin-sensitive group, levels of 25-(OH)D, IGF-1, and HDL-C were significantly lower in the insulin-resistant group (p < 0.001, p = 0.032, and p = 0.023, respectively), while TG and LDL-C levels were significantly higher (p < 0.001). No significant difference was observed in TC levels between the two groups (p = 0.334). Multivariate analysis identified 25-(OH)D (odds ratio [OR] = 0.934, 95% confidence interval [CI]: 0.877-0.995, p = 0.035), IGF-1 >238.68 (OR = 0.303, 95% CI: 0.103-0.894, p = 0.031), TG (OR = 3.979, 95% CI: 1.461-10.835, p = 0.007), and LDL-C (OR = 2.625, 95% CI: 1.398-4.928, p = 0.003) as independent factors associated with IR in children with obesity. ROC analysis showed that the areas under the curves (AUCs) for 25-(OH)D, IGF-1, TG, LDL-C, and the combined indicator were 0.692, 0.612, 0.775, 0.747, and 0.856, respectively (p < 0.001, p = 0.025, p < 0.001, p < 0.001, and p < 0.001). CONCLUSION: In children with obesity, serum 25-(OH)D, IGF-1, TG, and LDL-C are significantly associated with IR. CI - Copyright: (c) 2026 The Author(s). Published by IMR Press. FAU - Chu, Zhufei AU - Chu Z AD - Department of Pediatrics, The Affiliated Yangming Hospital of Ningbo University, 315400 Ningbo, Zhejiang, China. FAU - Liu, Yue AU - Liu Y AD - Department of Pediatrics, The Affiliated Yangming Hospital of Ningbo University, 315400 Ningbo, Zhejiang, China. FAU - Ye, Kejun AU - Ye K AD - Department of Pediatrics, The Affiliated Yangming Hospital of Ningbo University, 315400 Ningbo, Zhejiang, China. LA - eng PT - Journal Article PL - Singapore TA - Br J Hosp Med (Lond) JT - British journal of hospital medicine (London, England : 2005) JID - 101257109 RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) RN - 0 (Lipids) SB - IM MH - Humans MH - *Insulin Resistance/physiology MH - *Insulin-Like Growth Factor I/analysis/metabolism MH - *Vitamin D/analogs & derivatives/blood MH - Male MH - Female MH - Child MH - Retrospective Studies MH - *Lipids/blood MH - *Pediatric Obesity/blood OTO - NOTNLM OT - 25-hydroxyvitamin D OT - insulin resistance OT - insulin-like growth factor-1 OT - pediatric obesity EDAT- 2026/09/03 17:36 MHDA- 2026/09/03 17:37 CRDT- 2026/09/03 11:49 PHST- 2025/10/31 00:00 [received] PHST- 2026/03/25 00:00 [revised] PHST- 2026/04/23 00:00 [accepted] PHST- 2026/09/03 17:37 [medline] PHST- 2026/09/03 17:36 [pubmed] PHST- 2026/09/03 11:49 [entrez] AID - S1750-8460(26)03489-0 [pii] AID - 10.31083/BJHM56972 [doi] PST - ppublish SO - Br J Hosp Med (Lond). 2026 Aug 12;87(8):56972. doi: 10.31083/BJHM56972. PMID- 42689310 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 0970-0218 (Print) IS - 1998-3581 (Electronic) IS - 0970-0218 (Linking) VI - 51 IP - 4 DP - 2026 Jul-Aug TI - In-Service Training of Stakeholders Working for Particularly Vulnerable Tribal Groups (PVTGs) in an Eastern State of India: A Pre and Post- Training Assessment. PG - 686-693 LID - 10.4103/ijcm.ijcm_693_25 [doi] AB - BACKGROUND: Particularly vulnerable tribal groups (PVTGs) are among the most marginalized tribal communities in India. The uptake of government-led health and nutrition programmes by them is low owing to the geographical remoteness of their habitats, communication gaps between service providers and PVTG communities, and distinct cultural beliefs. Under the "Jiban Sampark" ("Connection with Life") project-a collaboration between the Government of Odisha, United Nations Children's Fund (UNICEF), and AIIMS Bhubaneswar-a structured training of trainers (ToT) programme was implemented to build the capacity of stakeholders serving these communities. The objective of this study was to implement and assess the effectiveness of the training programme on the knowledge of stakeholders working for PVTGs in tribal districts of Odisha, an eastern state of India. METHODS: A single-group pre-post (before-after) interventional study was conducted in 12 tribal districts from April 2019 to January 2020. Six modules were developed and vetted by subject experts for the training of different stakeholders including health officials, officials from Women and Child Development (WCD) departments, Non-Governmental Organization (NGO) personnel, and functionaries of the Odisha Livelihood Mission (OLM) and the Odisha PVTG Empowerment and Livelihood Programme (OPELIP). Three-day residential trainings covered six modules; knowledge was assessed across five domains-childhood malnutrition, adolescent health, antenatal and postnatal care, newborn care and immunization, and communication in service delivery-using a pretested, content-validated 20-item questionnaire administered immediately before and after training to 231 of the 242 participants trained. RESULTS: The mean total knowledge score improved significantly after training compared with before training (13.80 +/- 3.78 vs 11.55 +/- 5.19; paired t-test, P < 0.001). All five domains improved significantly by McNemar's test (all P < 0.0001). The pre-test overall knowledge was lowest among OPELIP staff and health functionaries (8.41 +/- 3.03 and 9.16 +/- 2.49, respectively). The post-test scores of health functionaries were highest across all domains, and their overall improvement was statistically significant (9.16 +/- 2.49 vs 15.48 +/- 4.19; P < 0.001). WCD functionaries, who had the highest baseline score, showed a significant decline in total score (14.85 +/- 6.37 vs 12.82 +/- 3.96; P = 0.023). CONCLUSION: The assessment of pre- and post-test results revealed a significant improvement in the knowledge of stakeholders across most domains and cadres. Hence, an administrative mechanism within the government system is needed to impart training to all stakeholders at regular intervals and to monitor the cascade training of frontline workers (FLWs). CI - Copyright: (c) 2026 Indian Journal of Community Medicine. FAU - Bhatia, Vikas AU - Bhatia V AD - Department of Community Medicine and Family Medicine, AIIMS Bhubaneswar, Odisha, India. FAU - Giri, Prajna Paramita AU - Giri PP AD - Department of Community Medicine and Family Medicine, AIIMS Bhubaneswar, Odisha, India. FAU - Taywade, Manish AU - Taywade M AD - Department of Community Medicine and Family Medicine, AIIMS Bhubaneswar, Odisha, India. FAU - Parida, Swayam Pragyan AU - Parida SP AD - Department of Community Medicine and Family Medicine, AIIMS Bhubaneswar, Odisha, India. FAU - Behera, Binod Kumar AU - Behera BK AD - Department of Community Medicine and Family Medicine, AIIMS Bhubaneswar, Odisha, India. FAU - Das, Sandeep AU - Das S AD - Department of Community Medicine and Family Medicine, AIIMS Bhubaneswar, Odisha, India. LA - eng PT - Journal Article DEP - 20260813 PL - India TA - Indian J Community Med JT - Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine JID - 9315574 PMC - PMC13537773 OTO - NOTNLM OT - Knowledge assessment OT - PVTG OT - scheduled tribe OT - training OT - tribal COIS- There are no conflicts of interest. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/07/01 CRDT- 2026/09/03 11:08 PHST- 2025/09/11 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 11:08 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - IJCM-51-686 [pii] AID - 10.4103/ijcm.ijcm_693_25 [doi] PST - ppublish SO - Indian J Community Med. 2026 Jul-Aug;51(4):686-693. doi: 10.4103/ijcm.ijcm_693_25. Epub 2026 Aug 13. PMID- 42689159 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 8 DP - 2026 Aug TI - Chrononutrition and Pediatric Metabolic Health: An Integrative Review of Circadian Biology and Early-Day Metabolic Regulation. PG - e113864 LID - 10.7759/cureus.113864 [doi] LID - e113864 AB - Childhood obesity remains one of the most important public health challenges worldwide, resulting from the complex interaction of biological, behavioral, environmental, and socioeconomic factors. Although substantial advances have been achieved in nutritional science, increasing evidence suggests that metabolic regulation is influenced not only by dietary composition but also by biological timing. This narrative conceptual review synthesizes current knowledge from chronobiology, chrononutrition, pediatric endocrinology, nutritional physiology, and behavioral nutrition to examine how early-day eating patterns may influence metabolic regulation during childhood. The available evidence indicates that metabolic responses emerge from the coordinated interaction among circadian organization, endocrine signaling, dietary quality, feeding behavior, and developmental physiology rather than from isolated nutritional variables alone. Based on this integrated interpretation, this review proposes the concept of the Early-Day Metabolic Window (EMW), defined as the physiological period immediately following overnight fasting during which circadian synchronization, endocrine responsiveness, metabolic flexibility, and nutrient sensing converge during the transition toward daytime metabolism. Building upon this concept, we present the Costa Reset Conceptual Model, an integrative physiological framework designed to organize current evidence into a unified interpretation of early-day metabolic regulation. Rather than proposing a new biological mechanism or a specific dietary intervention, the model provides a conceptual structure through which biological timing and nutritional exposures may be interpreted as interacting determinants of pediatric metabolic regulation. Although the proposed framework remains conceptual and requires prospective experimental validation, it generates biologically plausible and testable hypotheses that may guide future clinical and translational research. Integrating chrononutrition and temporal nutritional physiology into pediatric nutritional science may contribute to a more comprehensive understanding of childhood metabolic health and support future chrononutrition-based preventive and therapeutic strategies. CI - Copyright (c) 2026, Costa et al. FAU - Costa, Bruno AU - Costa B AD - Nutrition, Private Practice, Santos, BRA. LA - eng PT - Journal Article PT - Review DEP - 20260803 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13537081 OTO - NOTNLM OT - child health OT - chronobiology OT - chrononutrition OT - circadian rhythm OT - early-day metabolic window OT - feeding behavior OT - metabolism OT - pediatric metabolism OT - pediatric obesity COIS- Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/03 CRDT- 2026/09/03 10:50 PHST- 2026/08/02 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 10:50 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.7759/cureus.113864 [doi] PST - epublish SO - Cureus. 2026 Aug 3;18(8):e113864. doi: 10.7759/cureus.113864. eCollection 2026 Aug. PMID- 42689141 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Daily fiber supplementation after bariatric surgery demonstrates tolerability and influence on the fecal gut microbiome. PG - 1912097 LID - 10.3389/fnut.2026.1912097 [doi] LID - 1912097 AB - INTRODUCTION: This study assessed the feasibility and tolerance of a 30-day resistant potato starch (RPS) supplement in patients who recently underwent bariatric surgery and its effect on microbial production of fecal short-chain fatty acids (SCFA). METHODS: This clinical trial (ClinicalTrials.gov, identifier: NCT05653648), conducted at Dartmouth Hitchcock Medical Center, provided 30-days of RPS supplement (titration: 24 g for 15 days; 48 g for 15 days) starting 90-days post-op and assessed gastrointestinal symptoms, dietary intake (24 h recall), fecal SCFAs, and fecal gut microbiome (n = 30). RESULTS: The RPS supplement was well tolerated by participants (77% achieving consumption goal), with modest, but significant increases in self-reported gas (p = 0.004) and abdominal rumbling (p = 0.047). It was associated with an increase in the Bifidobacterium genus (LDA score >4, p < 0.001) and specifically, an enrichment of B. faecale/adolescentis (p = 0.006), one of two known primary degraders of RPS. No changes were observed in the abundance of cross-feeders or in SCFA concentrations. Alpha diversity measures were significantly lower post-RPS, and there was no change in species richness. DISCUSSION: This study demonstrated that a RPS supplement is tolerable in post-op bariatric patients and that the gut microbiome is responsive to fiber interventions. RPS increased the abundance of SCFA-producing bacteria but did not alter fecal SCFAs, likely due to competition among cross-feeders. CI - Copyright (c) 2026 Moser, Saxby, Lebby, Letendre, Lange, Mendez, Trus, Honigsberg, Billmeier, Gilbert-Diamond, Dao and Meijer. FAU - Moser, Brandy AU - Moser B AD - Department of Agriculture, Nutrition, and Food Systems, University of New Hampshire, Durham, NH, United States. FAU - Saxby, Solange M AU - Saxby SM AD - Department of Community and Family Medicine, Dartmouth Health, Lebanon, NH, United States. FAU - Lebby, Stephanie AU - Lebby S AD - Section of Obesity Medicine, Center for Digestive Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States. FAU - Letendre, Jennifer D AU - Letendre JD AD - Section of Bariatric Surgery, Center for Digestive Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States. FAU - Lange, Sarah AU - Lange S AD - Section of Bariatric Surgery, Center for Digestive Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States. FAU - Mendez, Marissa A AU - Mendez MA AD - Section of Bariatric Surgery, Center for Digestive Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States. FAU - Trus, Thadeus L AU - Trus TL AD - Section of Bariatric Surgery, Center for Digestive Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States. FAU - Honigsberg, Elizabeth AU - Honigsberg E AD - Section of Obesity Medicine, Center for Digestive Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States. FAU - Billmeier, Sarah E AU - Billmeier SE AD - Section of Bariatric Surgery, Center for Digestive Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, United States. FAU - Gilbert-Diamond, Diane AU - Gilbert-Diamond D AD - Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, United States. FAU - Dao, Maria Carlota AU - Dao MC AD - Department of Agriculture, Nutrition, and Food Systems, University of New Hampshire, Durham, NH, United States. FAU - Meijer, Jennifer L AU - Meijer JL AD - Department of Medicine, Geisel School of Medicine, Dartmouth College, Hanover, NH, United States. LA - eng SI - ClinicalTrials.gov/NCT05653648 PT - Journal Article DEP - 20260819 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13536892 OTO - NOTNLM OT - bariatric surgery OT - butyrate OT - fiber OT - gut microbiota OT - obesity OT - potato starch OT - short-chain fatty acids OT - supplementation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 10:48 PHST- 2026/06/17 00:00 [received] PHST- 2026/07/29 00:00 [revised] PHST- 2026/07/31 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 10:48 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/fnut.2026.1912097 [doi] PST - epublish SO - Front Nutr. 2026 Aug 19;13:1912097. doi: 10.3389/fnut.2026.1912097. eCollection 2026. PMID- 42688803 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - The moderated mediation effect of physical activity on non-suicidal self-injury: the mediating role of perceived stress and the moderating role of parental support. PG - 1824693 LID - 10.3389/fpsyt.2026.1824693 [doi] LID - 1824693 AB - OBJECTIVES: Non-suicidal self-injury (NSSI) has emerged as a significant public health challenge among adolescents globally. Although physical activity (PA) is widely recognized as a potential protective factor for mental health, the internal mechanisms through which it is associated with specific high-risk behaviors like NSSI remain insufficiently explored. This study aims to construct and validate a moderated mediation model to examine the association between PA and adolescent NSSI, the mediating role of perceived stress, and the boundary conditions set by parental support. METHODS: Utilizing a cross-sectional observational design and a stratified cluster sampling method, 402 adolescents (198 males and 204 females; mean age = 15.23 +/- 1.57 years) were recruited from five middle and high schools (three urban, two rural) in Sichuan Province, China. Participants completed a battery of psychometric instruments, including the Physical Activity Rating Scale-3 (PARS-3), the Perceived Stress Scale-10 (PSS-10), the Inventory of Parent and Peer Attachment (IPPA), and the Deliberate Self-Harm Inventory (DSHI). Data analysis was conducted using SPSS 26.0 and the PROCESS macro (Model 58). RESULTS: PA was significantly and negatively associated with adolescent NSSI (beta = -0.58, p < 0.001). Perceived stress partially mediated this relationship, with the indirect association accounting for 36.21% of the total effect. The substantial direct association (63.79%) suggests that PA may also relate to NSSI through other unmeasured pathways, such as speculative neurobiological adaptations or behavioral replacement. Furthermore, parental support significantly moderated the mediated process. Specifically, parental support moderated both the PA -> perceived stress pathway (beta = 0.15, p = 0.003) and the perceived stress -> NSSI pathway (beta = -0.14, p = 0.005), suggesting that the negative association between PA and stress is stronger under low parental support. CONCLUSIONS: PA serves as a potential protective factor negatively associated with NSSI through both direct and indirect statistical pathways. Parental support functions as a critical environmental buffer; for adolescents lacking parental support, PA serves as a crucial compensatory resource for stress management. These findings offer empirical evidence for the development of integrated family-school intervention strategies for adolescent mental health. CI - Copyright (c) 2026 Wang, Jia and Xu. FAU - Wang, Pengyu AU - Wang P AD - School of Public Administration, Henan University of Economics and Law, Zhengzhou, China. FAU - Jia, Hui AU - Jia H AD - Department of Marine-Sports, Pukyong National University, Busan, Republic of Korea. FAU - Xu, Jie AU - Xu J AD - Sichuan Technology and Business University, Meishan, China. LA - eng PT - Journal Article DEP - 20260819 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13535768 OTO - NOTNLM OT - moderated mediation OT - non-suicidal self-injury (NSSI) OT - parental support OT - perceived stress OT - physical activity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 09:56 PHST- 2026/03/06 00:00 [received] PHST- 2026/06/30 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 09:56 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1824693 [doi] PST - epublish SO - Front Psychiatry. 2026 Aug 19;17:1824693. doi: 10.3389/fpsyt.2026.1824693. eCollection 2026. PMID- 42688550 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 2813-2890 (Electronic) IS - 2813-2890 (Linking) VI - 5 DP - 2026 TI - Adolescent circadian sleep health: a review of multimodal assessment strategies and clinical implications. PG - 1826938 LID - 10.3389/frsle.2026.1826938 [doi] LID - 1826938 AB - The adolescent developmental period is marked by increased social and academic demands, as well as biological changes that lead to profound shifts in sleep and circadian timing. Circadian misalignment, short sleep duration, and irregular sleep patterns are prevalent among adolescents and are linked to a wide range of negative outcomes, including impaired emotional regulation, diminished academic performance, and increased cardiometabolic disease risk. While efforts to promote adolescent sleep health have grown, the multidimensional nature of circadian sleep health remains underassessed in both research and clinical contexts. This review provides conceptual definitions of key circadian sleep health concepts, synthesizing current best practices for measuring circadian sleep health in adolescents across self-report, behavioral, and physiological domains. We organize assessment strategies around three key circadian constructs-chronotype, circadian timing, and circadian alignment-and describe validated tools for each. In addition, we explore measurements of contextual factors influencing circadian function, such as light exposure, meal and exercise timing, pubertal status, and genetic predispositions. Throughout this review, we emphasize the value of a multimodal approach that combines subjective experience with objective biological and behavioral data to improve clinical utility and advance the understanding of circadian sleep health. We conclude by outlining directions for future research, including the need for validated, developmentally appropriate tools and the integration of wearable technologies to improve accessibility and clinical utility. By consolidating core concepts and methodological tools, this review aims to assist researchers and clinicians selecting appropriate assessment strategies and tailoring interventions to improve adolescent circadian sleep health. CI - Copyright (c) 2026 Jex, Larson Downs, Kamhout, Wright, Wright, Zhang and Duraccio. FAU - Jex, Jamon M AU - Jex JM AD - Department of Psychology, Brigham Young University, Provo, UT, United States. FAU - Larson Downs, Alyssa AU - Larson Downs A AD - Department of Psychology, Brigham Young University, Provo, UT, United States. FAU - Kamhout, Sarah AU - Kamhout S AD - Department of Psychology, Brigham Young University, Provo, UT, United States. FAU - Wright, Isabella D AU - Wright ID AD - Department of Psychology, Brigham Young University, Provo, UT, United States. FAU - Wright, Andrew AU - Wright A AD - Department of Psychology, Brigham Young University, Provo, UT, United States. FAU - Zhang, Victoria AU - Zhang V AD - Department of Psychology, Brigham Young University, Provo, UT, United States. FAU - Duraccio, Kara McRae AU - Duraccio KM AD - Department of Psychology, Brigham Young University, Provo, UT, United States. LA - eng PT - Journal Article PT - Review DEP - 20260819 PL - Switzerland TA - Front Sleep JT - Frontiers in sleep JID - 9918451286706676 PMC - PMC13535966 OTO - NOTNLM OT - adolescents OT - chronotype OT - circadian alignment OT - circadian misalignment OT - circadian sleep health OT - circadian timing OT - multimodal assessment OT - sleep health COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 09:19 PHST- 2026/03/10 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 09:19 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/frsle.2026.1826938 [doi] PST - epublish SO - Front Sleep. 2026 Aug 19;5:1826938. doi: 10.3389/frsle.2026.1826938. eCollection 2026. PMID- 42688531 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 1664-042X (Print) IS - 1664-042X (Electronic) IS - 1664-042X (Linking) VI - 17 DP - 2026 TI - Time-dependent changes in aerobic capacity of acute sub-high altitude exposure in elite youth endurance athletes. PG - 1916986 LID - 10.3389/fphys.2026.1916986 [doi] LID - 1916986 AB - PURPOSE: This study investigated the non-linear, time-dependent alterations in cardiorespiratory fitness, running economy (RE), and metabolic kinetics during the first week of acute exposure to a sub-high altitude (1,300 m) in elite youth endurance athletes. METHODS: Fourteen male national-level middle- and long-distance runners (age: 19.8 +/- 0.7 years; sea-level V O2max : 67.2 +/- 3.8 mL.kg(-)(1).min(-)(1)) completed field-based incremental exhaustion tests on a standard 400-m outdoor track at sea level (T0) and on day 1 (T1, within 18 h post-arrival), day 4 (T2), and day 6 (T3) after rapid rail-based ascent to 1,300 m. Maximal oxygen uptake ( V O2max ), peak running speed ( vV O2max ), and submaximal RE (steady-state V O2 at 12, 14, and 16 km.h(-)(1)) were assessed using an automated metabolic cart. Blood lactate concentration ([La(-)]b) and maximal heart rate (HRmax) were measured. Daily waking morning heart rate (morning HR) and resting arterial oxygen saturation (SpO(2)) were continuously monitored. Training volume was strictly standardized to 70% of the habitual sea-level load. RESULTS: One-way RM ANOVA revealed a significant main effect of time on V O2max ( F[3, 39] = 18.42, p < 0.001, etap2 = 0.59 ). Crucially, polynomial contrasts confirmed a highly significant quadratic trend ( Fquadratic[1, 13] = 34.21, ptrend < 0.001, etap2 = 0.72 ), statistically validating a non-linear V-shaped temporal kinetic profile. V O2max dropped from T1 to a distinct nadir at T2 ( - 7.0% , 95% CI:[60.1, 64.7] mL . kg-1 . min-1, p < 0.001 ), and partially rebounded at T3 . Concurrently, submaximal RE at 14 km/h significantly deteriorated at T2 , as evidenced by a 5.3% increase in distance-specific oxygen cost (from 210.5 +/- 12.4 at T1 to 221.7 +/- 14.2 mL . kg-1 . km-1 at T2 , p = 0.010 ), which also exhibited a significant quadratic pattern ( ptrend = 0.008 ). Post-exercise blood lactate peaked at T2 ( 11.2 +/- 1.4 mmol . L-1, p = 0.015 ), while HRmax remained statistically stable ( F[3, 39] = 0.21, p = 0.885, etap2 = 0.015 ). CONCLUSION: Acute relocation to 1,300 m induces a distinct physiological nadir on Day 4, which may be related to transient autonomic adjustments and respiratory muscle work, rather than hematological adaptations. Early adaptation emerges by Day 6. Coaches may consider closer monitoring and temporary adjustment of training intensity during the early days following ascent, particularly around day 4. CI - Copyright (c) 2026 Feng, Ning, Zhang, Tao, Sun and Wu. FAU - Feng, Junpeng AU - Feng J AD - China Winter Sports College, Beijing Sport University, Beijing, China. FAU - Ning, Fengming AU - Ning F AD - College of Education, Beijing Sport University, Beijing, China. FAU - Zhang, Xuchang AU - Zhang X AD - College of Education, Beijing Sport University, Beijing, China. FAU - Tao, Ye AU - Tao Y AD - College of Education, Beijing Sport University, Beijing, China. FAU - Sun, Mingyue AU - Sun M AD - Department of Physical Education, Beijing City University, Beijing, China. FAU - Wu, Wenqiang AU - Wu W AD - College of Education, Beijing Sport University, Beijing, China. LA - eng PT - Journal Article DEP - 20260819 PL - Switzerland TA - Front Physiol JT - Frontiers in physiology JID - 101549006 PMC - PMC13534102 OTO - NOTNLM OT - endurance OT - hypoxic acclimatization OT - running economy OT - sub-high altitude OT - youth athletes COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 09:16 PHST- 2026/06/23 00:00 [received] PHST- 2026/07/24 00:00 [revised] PHST- 2026/07/28 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 09:16 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/fphys.2026.1916986 [doi] PST - epublish SO - Front Physiol. 2026 Aug 19;17:1916986. doi: 10.3389/fphys.2026.1916986. eCollection 2026. PMID- 42688474 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Cultural adaptation, validation, and first application of the Canadian assessment of physical literacy (CAPL-2) in Lithuanian primary school children. PG - 1922697 LID - 10.3389/fspor.2026.1922697 [doi] LID - 1922697 AB - INTRODUCTION: Physical literacy is increasingly recognized as a multidimensional construct that supports lifelong engagement in physical activity. Although the Canadian Assessment of Physical Literacy, second edition (CAPL-2), is one of the most widely used instruments for assessing physical literacy in children, no culturally adapted and validated Lithuanian version has previously been available. This study aimed to translate and culturally adapt CAPL-2 for Lithuanian primary school children, evaluate its psychometric properties, and report the findings from its first application in a national sample. METHODS: CAPL-2 was translated and culturally adapted following established international guidelines, including forward-backward translation, expert review, and pilot testing. The adapted instrument was administered to 846 children aged 8-11 years from 10 Lithuanian schools. Descriptive statistics, Pearson correlations, confirmatory factor analysis, age- and sex-group comparisons, and internal consistency analyses were performed. RESULTS: The Lithuanian CAPL-2 demonstrated good psychometric properties and retained the original four-domain structure (CFI = .963, TLI = .946, RMSEA = .047, SRMR = .040). The Motivation and Confidence domain showed good internal consistency (Cronbach's alpha = .867; McDonald's omega = .87). The mean total CAPL-2 score was 70.25/100. Motivation and Confidence showed the highest domain scores, whereas Knowledge and Understanding demonstrated the weakest associations with the remaining domains and no significant correlation with Daily Behavior. Significant age-related differences were observed for Physical Competence and Knowledge and Understanding. CONCLUSION: The Lithuanian version of CAPL-2 is a valid and culturally appropriate instrument for assessing physical literacy in primary school children. The findings support its use in research, education, and public health and provide a foundation for future national and international studies. CI - (c) 2026 Vizbariene, Mieziene, Rutkauskaite and Emeljanovas. FAU - Vizbariene, Audrone AU - Vizbariene A AD - Department of Physical and Social Education, Lithuanian Sports University, Kaunas, Lithuania. FAU - Mieziene, Brigita AU - Mieziene B AD - Department of Physical and Social Education, Lithuanian Sports University, Kaunas, Lithuania. FAU - Rutkauskaite, Renata AU - Rutkauskaite R AD - Department of Physical and Social Education, Lithuanian Sports University, Kaunas, Lithuania. FAU - Emeljanovas, Arunas AU - Emeljanovas A AD - Department of Physical and Social Education, Lithuanian Sports University, Kaunas, Lithuania. LA - eng PT - Journal Article DEP - 20260819 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13534132 OTO - NOTNLM OT - CAPL-2 OT - cross-cultural adaptation and validation OT - physical education OT - physical literacy OT - primary school children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor BO declared a past co-authorship/collaboration ("Compatibility of physical education curricula with physical literacy across 40 European countries") with the authors BM and AE. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 08:59 PHST- 2026/06/29 00:00 [received] PHST- 2026/07/25 00:00 [revised] PHST- 2026/07/31 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 08:59 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/fspor.2026.1922697 [doi] PST - epublish SO - Front Sports Act Living. 2026 Aug 19;8:1922697. doi: 10.3389/fspor.2026.1922697. eCollection 2026. PMID- 42688190 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Clinical correlates of depressed adolescents comorbid with food addiction: a cross-sectional study. PG - 1909728 LID - 10.3389/fpsyt.2026.1909728 [doi] LID - 1909728 AB - BACKGROUND: Food addiction (FA) involves the excessive intake of ultra-processed foods and is prevalent among individuals with major depressive disorder (MDD). Despite this association, evidence regarding FA in adolescents with MDD is limited. This investigation sought to examine the relationship between FA and clinical features in this demographic, aiming to clarify the prevalence of FA and offer theoretical insights for clinical management. METHODS: A total of 194 depressed adolescents were recruited at the Fourth Affiliated Hospital of Anhui Medical University between September 2022 and June 2025. Validated multidimensional scales were used to assess FA, depression, anxiety, perceived stress, and internet addiction (IA). Subsequently, stepwise regression analysis was performed to identify independent factors of FA, and receiver operating characteristic (ROC) curve analysis was conducted for these predictors, with the area under the curve (AUC) calculated. RESULTS: The prevalence of FA in depressed adolescents was 17.5%. Multivariate logistic regression identified BMI (OR = 1.149, 95% CI = 1.051 - 1.257, P = 0.002), anxiety (OR = 1.116, 95% CI = 1.039 - 1.198, P = 0.002), perceived stress (OR = 1.137, 95% CI = 1.030 - 1.254, P = 0.011), and IA (OR = 1.051, 95% CI = 1.020 - 1.083, P = 0.001) as independent risk factors of FA. Furthermore, ROC curve analysis demonstrated that a combined model comprising these four factors exhibited superior discriminatory ability for identifying FA (AUC = 0.861, 95% CI = 0.801 - 0.921, P < 0.001). CONCLUSION: FA affects some adolescents with MDD and is closely associated with BMI, anxiety, perceived stress, and IA. Clinicians should integrate screening for this abnormal eating behavior and related psychosocial factors into routine care. CI - Copyright (c) 2026 Sun, Liu, Tang, Fan, Hao, Zhang and Liu. FAU - Sun, Liling AU - Sun L AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Liu, Lewei AU - Liu L AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Tang, Pei AU - Tang P AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Fan, Haojie AU - Fan H AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Hao, Mingru AU - Hao M AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Zhang, Kai AU - Zhang K AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. FAU - Liu, Huanzhong AU - Liu H AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China. LA - eng PT - Journal Article DEP - 20260819 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13534092 OTO - NOTNLM OT - adolescent OT - clinical characteristics OT - food addiction OT - major depressive disorder OT - receiver operating characteristic COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors HL, KZ declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 07:09 PHST- 2026/06/15 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/08/07 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 07:09 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1909728 [doi] PST - epublish SO - Front Psychiatry. 2026 Aug 19;17:1909728. doi: 10.3389/fpsyt.2026.1909728. eCollection 2026. PMID- 42688108 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Digital health literacy and disordered eating among adolescents: the chain mediating roles of physical activity and problematic social media use. PG - 1937781 LID - 10.3389/fpsyt.2026.1937781 [doi] LID - 1937781 AB - BACKGROUND: Digital environments may increase adolescents' vulnerability to disordered eating through misleading health information and problematic social media use. This study examined the association between digital health literacy and disordered eating, including the independent and serial indirect associations of physical activity and problematic social media use. METHODS: This cross-sectional study included 2,206 adolescents recruited from five secondary schools using purposive and convenience sampling. Participants had a mean age of 14.50 years (SD = 1.76). Digital health literacy, disordered eating, physical activity, and problematic social media use were assessed using validated scales. Correlation and bootstrap-based regression analyses were conducted to estimate the specific and serial indirect associations. RESULTS: Digital health literacy was negatively associated with disordered eating and problematic social media use and positively associated with physical activity. The total association between digital health literacy and disordered eating was -0.324 (95% CI [-0.365, -0.283]), including a direct association of -0.135 (95% CI [-0.177, -0.092]). Indirect associations were observed through physical activity (-0.098, 95% CI [-0.121, -0.077]), problematic social media use (-0.072, 95% CI [-0.089, -0.057]), and physical activity followed by problematic social media use (-0.019, 95% CI [-0.024, -0.015]). CONCLUSION: Digital health literacy was associated with disordered eating through independent and serial indirect associations involving physical activity and problematic social media use. These findings suggest the value of coordinated school- and family-based strategies integrating digital health literacy education, physical activity promotion, responsible social media use, and early identification of disordered eating. CI - Copyright (c) 2026 Ding, Zhao, Qu, Tang, Shang, Lyu and Li. FAU - Ding, Xuyao AU - Ding X AD - College of Physical Education, Henan University, Kaifeng, Henan, China. FAU - Zhao, Chuyuan AU - Zhao C AD - College of Physical Education, Henan University, Kaifeng, Henan, China. FAU - Qu, Jiaqi AU - Qu J AD - College of Physical Education, Henan University, Kaifeng, Henan, China. FAU - Tang, Chen AU - Tang C AD - College of Physical Education, Henan University, Kaifeng, Henan, China. FAU - Shang, Chuxi AU - Shang C AD - College of Physical Education, Henan University, Kaifeng, Henan, China. FAU - Lyu, Jianing AU - Lyu J AD - Body-Brain-Mind Laboratory, School of Psychology, Wuhan Sports University, Wuhan, China. FAU - Li, Zhen AU - Li Z AD - School of Physical Education, Henan Kaifeng College of Science Technology and Communication, Kaifeng, Henan, China. LA - eng PT - Journal Article DEP - 20260819 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13533913 OTO - NOTNLM OT - adolescents OT - digital health literacy OT - disordered eating OT - physical activity OT - problematic social media use COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 06:24 PHST- 2026/07/14 00:00 [received] PHST- 2026/07/31 00:00 [revised] PHST- 2026/08/07 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 06:24 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1937781 [doi] PST - epublish SO - Front Psychiatry. 2026 Aug 19;17:1937781. doi: 10.3389/fpsyt.2026.1937781. eCollection 2026. PMID- 42687936 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260904 IS - 2813-2890 (Electronic) IS - 2813-2890 (Linking) VI - 5 DP - 2026 TI - Exploring nightly variability in sleep apnea and changes in severity classification with multi night sleep testing in a population based cohort of young children. PG - 1903809 LID - 10.3389/frsle.2026.1903809 [doi] LID - 1903809 AB - BACKGROUND: Obstructive sleep apnea (OSA) is typically evaluated with single-night sleep studies. In adults, night-to-night variability (NtNV) is well documented, but less so in children. The current study evaluated NtNV in apnea events for misclassification in disease severity in young children to investigate if multi-night sleep-recordings may be clinically relevant to improve diagnostic accuracy and affect treatment decisions. METHODS: Parents/guardians of healthy 4-9-year-old children participating in a study to evaluate prevalence of OSA were asked to record the child's sleep for up to 5-nights. This analysis is from children who completed three consecutive night sleep recordings. RESULTS: Average age of participants was 6.1 years (n = 200, 58.0%-girls/42.0%-boys), prevalence of overweight/obesity was 25% and moderate-severe-OSA (AHI(3%) >/= 5) based on single-night testing protocol was 29.0%. Using the highest AHI(3%) value from the three recordings, the first-night correctly identified 57.0% of participants and adding a second night identified 86.0% of participants, with 14% of participants not identified until the third night of sleep testing.Bland-Altman plots (BA(plots)) demonstrated non-statistically significant mean-differences and 95% upper and lower-limits (LOA(95%)) close in absolute terms night-one/night-two; -0.024 events/hour-of-sleep LOA(95%) [-5.062, 5.013], 8.0% of observations outside the LOA(95%) (p = 0.894) and night-two/night-three; -0.009 events/hour of sleep, LOA(95%) [-5.227, 5.209] and 6.0% of observations outside LOA(95%), (p = 0.9620).The intra-class correlation coefficient (ICC) for AHI(3%) for all 3 nights was 0.45 [0.37, 0.54], p < 0.001, for night-one/night-two (0.44; p < 0.001), and night-two/night-three (0.44; p < 0.001). Cohens Kappa (0.304-0.462) and Brennan-Prediger Kappa (0.403-0.490), respectively indicated low-to-moderate interrater agreement, with quadratic-weighted Cohen's Kappa for the four ordinal severity categories of 0.37 and 0.48 for the two night-pairs, demonstrating NtNV, which is consistent with the variability demonstrated by the BA(plots). CONCLUSION: Observed NtNV in apnea events affected severity categorization, suggesting that multi-night sleep testing may have clinical value and improve accuracy of sleep apnea evaluation in young children. CLINICAL TRIAL REGISTRATION: URL: clinicaltrials.gov/study/NCT05479201, identifier NCT0547920 . CI - Copyright (c) 2026 Magnusdottir, Ingolfsdottir, Hilmisson, Hrolfsdottir, Birkisson, Hallgrimsdottir, Johannesdottir and Petersen. FAU - Magnusdottir, Solveig AU - Magnusdottir S AD - MyCardio LLC, Denver, CO, United States. FAU - Ingolfsdottir, Ingibjorg AU - Ingolfsdottir I AD - Akureyri Hospital, Pediatrics, Akureyri, Iceland. AD - University of Iceland, Reykjavik, Iceland. FAU - Hilmisson, Hugi AU - Hilmisson H AD - MyCardio LLC, Denver, CO, United States. FAU - Hrolfsdottir, Laufey AU - Hrolfsdottir L AD - Institution of Health Science Research, University of Akureyri and Akureyri Hospital, Akureyri, Iceland. FAU - Birkisson, Magnus AU - Birkisson M AD - Akureyri Hospital, Ear Nose Throat, Akureyri, Iceland. FAU - Hallgrimsdottir, Erla AU - Hallgrimsdottir E AD - Aarhus University, Aarhus, Denmark. FAU - Johannesdottir, Groa AU - Johannesdottir G AD - Akureyri Hospital, Pediatrics, Akureyri, Iceland. FAU - Petersen, Hannes AU - Petersen H AD - University of Iceland, Reykjavik, Iceland. AD - Akureyri Hospital, Ear Nose Throat, Akureyri, Iceland. LA - eng SI - ClinicalTrials.gov/NCT05479201 PT - Journal Article DEP - 20260819 PL - Switzerland TA - Front Sleep JT - Frontiers in sleep JID - 9918451286706676 PMC - PMC13533644 OTO - NOTNLM OT - apnea hypopnea index OT - children OT - diagnostic accuracy OT - night-to-night variability OT - sleep apnea COIS- SM was employed by MyCardio LLC. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author HP declared being an editorial board member of Vestibular Disorders, Frontiers in Audiology and Otology, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/09/03 12:09 MHDA- 2026/09/03 12:10 PMCR- 2026/08/19 CRDT- 2026/09/03 05:18 PHST- 2026/06/08 00:00 [received] PHST- 2026/07/03 00:00 [revised] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/09/03 12:10 [medline] PHST- 2026/09/03 12:09 [pubmed] PHST- 2026/09/03 05:18 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - 10.3389/frsle.2026.1903809 [doi] PST - epublish SO - Front Sleep. 2026 Aug 19;5:1903809. doi: 10.3389/frsle.2026.1903809. eCollection 2026. PMID- 42687173 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260905 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Aug 13 TI - Population-adapted Nolla method for dental age estimation in Northwestern Romanian children. LID - 10.1186/s12903-026-09588-6 [doi] LID - 1654 AB - OBJECTIVES: Accurate dental age (DA) estimation is essential in pediatric dentistry, orthodontic treatment planning, and forensic practice; however, the applicability of international reference standards varies across populations. This study aimed to evaluate the accuracy of a population-adapted Nolla method for dental age estimation in children from northwestern Romania and to compare its performance with the original approach. MATERIALS AND METHODS: A retrospective analysis was performed on 860 digital panoramic radiographs of children aged 3-15 years. Dental development was assessed using the Nolla staging system, and a third-degree polynomial regression model was developed to estimate chronological age (CA) based on the total Nolla score. Model performance was evaluated using coefficient of determination (R(2)), five-fold cross-validation, and non-parametric statistical tests. RESULTS: The original Nolla method underestimated CA by approximately 1.5 years. The population-specific model showed strong predictive performance (R(2) = 0.846; cross-validated R(2) = 0.84) and close agreement between estimated DA and CA (mean difference 0.000 +/- 0.976 years; p = 0.983). Accuracy was stable across most age groups, although larger deviations were observed after 12 years. Girls showed slightly more advanced dental maturation than boys, but differences were clinically small. CONCLUSIONS: The proposed population-calibrated equation eliminates systematic bias and provides a reliable tool for dental age estimation in children from northwestern Romania, although external validation is recommended. CI - (c) 2026. The Author(s). FAU - Moga, Ligia Ioana AU - Moga LI AD - Doctoral School of Biomedical Sciences, University of Oradea, Oradea, Romania. FAU - Iurcov, Raluca AU - Iurcov R AD - Department of Dental Medicine, University of Oradea, Oradea, Romania. FAU - Moca, Abel Emanuel AU - Moca AE AD - Department of Dental Medicine, University of Oradea, Oradea, Romania. abelmoca@uoradea.ro. FAU - Csep, Andrei AU - Csep A AD - Department of Psycho-Neurosciences and Recovery, University of Oradea, Oradea, Romania. csep.andrei@gmail.com. FAU - Slavescu, Dan AU - Slavescu D AD - Department of Dental Medicine, University of Oradea, Oradea, Romania. FAU - Dima, Raluca AU - Dima R AD - Department of Dental Medicine, University of Oradea, Oradea, Romania. FAU - Vaida, Ligia Luminita AU - Vaida LL AD - Department of Dental Medicine, University of Oradea, Oradea, Romania. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260813 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Romania MH - Child MH - Child, Preschool MH - Retrospective Studies MH - Radiography, Panoramic MH - Female MH - Male MH - Adolescent MH - Reproducibility of Results PMC - PMC13536641 OTO - NOTNLM OT - Dental age estimation OT - Dental maturation OT - Nolla method OT - Romanian children COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the ethical principles of the Declaration of Helsinki (1964) and its subsequent amendments. Ethical approval was obtained from the Research Ethics Committee of the Faculty of Medicine and Pharmacy, University of Oradea (Approval No. CEFMF/1, issued on 30 July 2024). Written informed consent was obtained from the parents or legal guardians for the use of anonymized radiographic data for research purposes. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/03 05:37 MHDA- 2026/09/03 05:38 PMCR- 2026/08/13 CRDT- 2026/09/03 02:01 PHST- 2026/03/10 00:00 [received] PHST- 2026/08/07 00:00 [accepted] PHST- 2026/09/03 05:38 [medline] PHST- 2026/09/03 05:37 [pubmed] PHST- 2026/09/03 02:01 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - 10.1186/s12903-026-09588-6 [pii] AID - 9588 [pii] AID - 10.1186/s12903-026-09588-6 [doi] PST - epublish SO - BMC Oral Health. 2026 Aug 13;26(1):1654. doi: 10.1186/s12903-026-09588-6. PMID- 42686933 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260912 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 9 DP - 2026 Sep 3 TI - Complete blood count-derived inflammatory biomarkers and neonatal cholestasis in preterm infants: a matched case-control study. LID - 713 [pii] LID - 10.1007/s00431-026-07387-3 [doi] AB - Inflammation has been implicated in neonatal cholestasis, but associations between complete blood count (CBC)-derived inflammatory biomarkers and cholestasis remain unclear. This study evaluated these associations in preterm infants. This retrospective 1:1 matched case-control study included 284 cholestatic cases and 284 matched controls. Eight biomarkers were evaluated: neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), neutrophil-plus-monocyte-to-lymphocyte ratio (NMLR), systemic inflammation response index (SIRI), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), neutrophil-to-lymphocyte-to-platelet ratio (NLPR), and prognostic nutritional index (PNI). Conditional logistic regression, restricted cubic spline, subgroup, interaction, and sensitivity analyses were performed. In fully adjusted models, higher levels of NLPR, NLR, NMLR, PNI, and SIRI remained associated with an increased risk of cholestasis, whereas PLR was inversely associated with cholestasis risk. Specifically, each unit increase in NLR, NMLR, and SIRI was associated with a 28% (OR = 1.28, 95% CI: 1.07-1.53), 23% (OR = 1.23, 95% CI: 1.05-1.44), and 8% (OR = 1.08, 95% CI: 1.01-1.16) increase in cholestasis risk, respectively, whereas higher PLR was associated with a lower risk of cholestasis (OR = 0.99, 95% CI: 0.99-1.00). Tertile analyses showed higher odds of cholestasis in the highest NLPR tertile and lower odds in the higher PLR tertiles. Compared with the lowest tertile, infants in the highest tertile had a 2.19-fold higher risk of cholestasis for NLPR (OR = 2.19, 95% CI: 1.34-3.58). Conversely, higher tertiles of platelet-to-lymphocyte ratio (PLR) were associated with a reduced risk of cholestasis, with infants in the highest tertile showing significantly lower odds than those in the lowest tertile (T3 vs. T1: OR = 0.44, 95% CI: 0.27-0.72). Restricted cubic spline analyses revealed that PLR exhibited a L-shaped relationship with cholestasis risk. Subgroup and interaction analyses suggested that the observed associations were generally robust across clinical subgroups. CONCLUSION: Several routinely available CBC-derived inflammatory biomarkers were associated with neonatal cholestasis in preterm infants. These findings are associational and require prospective validation before the biomarkers can be used for prediction or clinical decision-making. WHAT IS KNOWN: * Systemic inflammation has been hypothesized to be involved in neonatal cholestasis, but its contribution to the development of cholestasis in preterm infants remains insufficiently established. * Evidence regarding the associations between complete blood count-derived inflammatory biomarkers and neonatal cholestasis is limited. WHAT IS NEW: * Higher NLPR, NLR, NMLR, PNI, and SIRI levels were associated with higher odds of neonatal cholestasis, whereas PLR showed an inverse association. * These findings provide epidemiological support for the hypothesis that systemic inflammation may be involved in neonatal cholestasis, although causality cannot be established. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Li, Xueying AU - Li X AD - Department of Neonatology, Children's Medical Center, The First Hospital of Jilin University, No. 1 Xinmin St., Changchun, Jilin, 130021, China. FAU - Liu, Yang AU - Liu Y AD - Department of Neonatology, Children's Medical Center, The First Hospital of Jilin University, No. 1 Xinmin St., Changchun, Jilin, 130021, China. FAU - Yang, Xia AU - Yang X AD - Department of Neonatology, Children's Medical Center, The First Hospital of Jilin University, No. 1 Xinmin St., Changchun, Jilin, 130021, China. FAU - Kong, Yanan AU - Kong Y AD - Department of Neonatology, Children's Medical Center, The First Hospital of Jilin University, No. 1 Xinmin St., Changchun, Jilin, 130021, China. FAU - Zhou, Qi AU - Zhou Q AD - Department of Neonatology, Children's Medical Center, The First Hospital of Jilin University, No. 1 Xinmin St., Changchun, Jilin, 130021, China. zhou_qi@jlu.edu.cn. LA - eng PT - Journal Article DEP - 20260903 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Cholestasis/blood/diagnosis/etiology MH - Infant, Newborn MH - Biomarkers/blood MH - Case-Control Studies MH - Male MH - Female MH - Retrospective Studies MH - Infant, Premature MH - Blood Cell Count MH - *Inflammation/blood MH - Neutrophils MH - *Infant, Premature, Diseases/blood/diagnosis MH - Logistic Models OTO - NOTNLM OT - Case-control study OT - Inflammatory biomarkers OT - Neonatal cholestasis OT - Preterm infants COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the First Hospital of Jilin University (No. AF-IRB-032-07). The requirement for informed consent was waived by the Ethics Committee of the First Hospital of Jilin University because of the retrospective study design and the use of anonymized clinical data. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/09/03 05:36 MHDA- 2026/09/03 05:37 CRDT- 2026/09/03 01:08 PHST- 2026/07/07 00:00 [received] PHST- 2026/08/30 00:00 [accepted] PHST- 2026/08/17 00:00 [revised] PHST- 2026/09/03 05:37 [medline] PHST- 2026/09/03 05:36 [pubmed] PHST- 2026/09/03 01:08 [entrez] AID - 10.1007/s00431-026-07387-3 [pii] AID - 10.1007/s00431-026-07387-3 [doi] PST - epublish SO - Eur J Pediatr. 2026 Sep 3;185(9):713. doi: 10.1007/s00431-026-07387-3. PMID- 42684799 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260919 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Sep 2 TI - A Digital Registry and Education Network for Child Maltreatment Protection: Protocol for a Pilot Observational Exploratory Intervention Study. PG - e89128 LID - 10.2196/89128 [doi] LID - e89128 AB - BACKGROUND: Child maltreatment, a major public health concern, has long-term neurobiological, psychological, and social consequences. Recognizing, documenting, and reporting suspected cases should be systematic across hospital and community services, but these processes are hindered by inconsistent surveillance systems, uneven professional training, and the lack of standardized data collection tools. Timely follow-up, updated clinical criteria, and structured multidisciplinary training can improve case assessment, traceability, and professionals' ability to report suspected maltreatment. The Sentinel project was developed to address these clinical, organizational, and public health gaps through a combined REDCap-based digital registry and structured training program for pediatric health care professionals. OBJECTIVE: This study aims to evaluate the usability, feasibility, and preliminary impact of an integrated surveillance and training system designed to improve the early detection, documentation, and reporting of suspected child maltreatment by pediatricians and health care professionals. METHODS: This is an observational, exploratory, monocentric pilot implementation study with a pretest-posttest evaluation design. The study will be conducted over 24 months in a hospital-community pediatric network. Voluntary participants will be hospital and community pediatricians and other pediatric health care professionals who provide written informed consent. The project includes two interconnected components: (1) implementation of a secure, anonymized REDCap registry for standardized documentation of suspected maltreatment, follow-up, reporting pathways, and case management outcomes and (2) a theoretical-practical training program delivered through lectures, e-learning modules, webinars, supervised exercises, and hands-on registry sessions. Primary and secondary outcomes will be assessed at prespecified time points, including baseline, immediately after training, during registry use, and at the end of follow-up. Registry usability will be measured using the System Usability Scale; training effectiveness will be measured through pretest-posttest knowledge, competency tests, and satisfaction questionnaires; and reporting outcomes will be measured through comparison of pre- and postimplementation reporting rates. RESULTS: The study will report the usability, feasibility, and preliminary implementation outcomes of the integrated registry training system. Main results will include System Usability Scale scores, registry completion indicators, reporting timeliness, the number and rate of suspected maltreatment reports before and after implementation, changes in knowledge and competency scores, participant satisfaction, and qualitative feedback on barriers to and facilitators of implementation. Participant recruitment and data collection began in April 2026 and are currently ongoing. Completion of data collection and publication of the results are expected between December 2027 and January 2028. CONCLUSIONS: The Sentinel project will test an innovative and scalable pilot model that integrates digital surveillance with structured professional training to enhance the early detection, documentation, and management of suspected child maltreatment. By standardizing data collection, strengthening professional competencies, and fostering collaboration across hospital and community settings, the study will inform the development of a regional or national observatory and support an evidence-based, system-wide approach to child protection. TRIAL REGISTRATION: ClinicalTrials.gov NCT07250074; https://clinicaltrials.gov/study/NCT07250074. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): PRR1-10.2196/89128. CI - (c)Gianvincenzo Zuccotti, Dario Dilillo, Antonella Agosto, Valeria Brazzoduro, Eloisa Brunilde Lina Marinelli, Valeria Calcaterra. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 02.09.2026. FAU - Zuccotti, Gianvincenzo AU - Zuccotti G AUID- ORCID: 0000-0002-2795-9874 AD - Department of Biomedical and Clinical Sciences, University of Milan, Milano, Lombardy, Italy. AD - Department of Pediatrics, Ospedale dei Bambini Vittore Buzzi, Milano, Lombardy, Italy. FAU - Dilillo, Dario AU - Dilillo D AUID- ORCID: 0000-0002-5978-6146 AD - Department of Pediatrics, Ospedale dei Bambini Vittore Buzzi, Milano, Lombardy, Italy. FAU - Agosto, Antonella AU - Agosto A AUID- ORCID: 0009-0000-0917-2261 AD - Department of Pediatrics, Ospedale dei Bambini Vittore Buzzi, Milano, Lombardy, Italy. FAU - Brazzoduro, Valeria AU - Brazzoduro V AUID- ORCID: 0009-0003-4270-0611 AD - Department of Pediatrics, Ospedale dei Bambini Vittore Buzzi, Milano, Lombardy, Italy. FAU - Marinelli, Eloisa Brunilde Lina AU - Marinelli EBL AUID- ORCID: 0009-0001-9259-0962 AD - Azienda Socio-Sanitaria Territoriale Fatebenefratelli Sacco, Milano, Lombardy, Italy. FAU - Calcaterra, Valeria AU - Calcaterra V AUID- ORCID: 0000-0002-2137-5974 AD - Department of Pediatrics, Ospedale dei Bambini Vittore Buzzi, Milano, Lombardy, Italy. AD - Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Lombardy, Italy. LA - eng SI - ClinicalTrials.gov/NCT07250074 PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20260902 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - *Child Abuse/prevention & control/diagnosis MH - *Registries/statistics & numerical data MH - Pilot Projects MH - Child MH - Research Design PMC - PMC13583510 OTO - NOTNLM OT - child maltreatment OT - children OT - digital registry OT - education network OT - protection COIS- Conflicts of Interest: None declared. EDAT- 2026/09/03 01:13 MHDA- 2026/09/03 01:14 PMCR- 2026/09/02 CRDT- 2026/09/02 12:04 PHST- 2025/12/07 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/06/13 00:00 [revised] PHST- 2026/09/03 01:14 [medline] PHST- 2026/09/03 01:13 [pubmed] PHST- 2026/09/02 12:04 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - v15i1e89128 [pii] AID - 10.2196/89128 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Sep 2;15:e89128. doi: 10.2196/89128. PMID- 42684739 OWN - NLM STAT- Publisher LR - 20260902 IS - 1939-3229 (Electronic) IS - 1939-3210 (Linking) DP - 2026 Sep 2 TI - Organochlorine pesticide residues in cow's milk, honey, and poultry eggs in Algiers, Algeria, and associated health risk. PG - 1-13 LID - 10.1080/19393210.2026.2714426 [doi] AB - Organochlorine pesticide residues were determined in 180 animal-derived food samples (cow's milk, honey, and poultry eggs) from three zones in Algiers (Rouiba, Zeralda, and Beraki) to evaluate their chronic non-carcinogenic health risks. Method validation using GC-MS demonstrated high precision and linearity (R(2) > 0.995), satisfactory recovery rates (76.9-91.4%) and LOQs of 0.001-0.009 microg/kg. Analysis revealed a pronounced geographic profile, positioning Beraki as a major environmental hotspot, with mean levels up to 15.18 microg/kg for endrin in milk, 11.44 microg/kg for gamma-BHC in honey, and 39.46 microg/kg for gamma-BHC in eggs. While dietary intake from Rouiba and Zeralda proved to be toxicologically safe, the cumulative hazard indices (HIs) for infants consuming Beraki-sourced milk (HI = 1.19) and honey (HI = 1.55) exceeded the threshold of 1. Conversely, poultry egg consumption was considered to be safe across all regions (HI < 1). These findings highlight a localised public health concern for the local population in Beraki. FAU - Chebli, Akli Islem AU - Chebli AI AUID- ORCID: 0000-0001-9242-9733 AD - Department of Pharmacy, Faculty of Pharmacy, University of Medical Sciences, Algiers, Algeria. AD - Research and Development Department, National Center of Toxicology, Algiers, Algeria. FAU - Iko Afe, O Herbert AU - Iko Afe OH AD - Department of Nutrition, Food Sciences and Technology, Faculty of Agronomic Sciences, University of Abomey-Calavi, Cotonou, Benin. FAU - Uc-Peraza, Russell Giovanni AU - Uc-Peraza RG AUID- ORCID: 0000-0003-4014-3172 AD - Division de Ciencias, Ingenieria Y Tecnologia, Universidad Autonoma Del Estado de Quintana Roo (UAEQROO), Chetumal, Mexico. FAU - Kindossi, Janvier Melegnonfan AU - Kindossi JM AD - Laboratory of Applied Modelling in Nutrition and Food Sciences, Department of Nutrition and Food Sciences, Faculty of Agronomy, University of Parakou, Algiers, Benin. FAU - Fassinou, Grace L Setondji AU - Fassinou GLS AD - Laboratory of Human Nutrition and Valorization of Food Bio-Ingredients, Faculty of Agricultural Sciences, University of Abomey-Calavi, Jericho Cotonou, Benin. FAU - Mehouel, Fetta AU - Mehouel F AUID- ORCID: 0000-0001-9771-2183 AD - Laboratory of Research Food Hygiene and Quality Insurance System (HASAQ), Institute of Veterinary Sciences, University of Constantine 1, Constantine, Algeria. AD - Department of Veterinary Sciences, Higher National Veterinary School of Algiers (ENSV- Alger), Algiers, Algeria. FAU - Zergui, Anissa AU - Zergui A AUID- ORCID: 0000-0001-8074-4082 AD - Department of Pharmacy, Faculty of Medicine, University of Oran, Oran, Algeria. FAU - Amziane, Ahmed AU - Amziane A AD - Department of Pharmacy, Faculty of Pharmacy, University of Medical Sciences, Algiers, Algeria. AD - Research and Development Department, National Center of Toxicology, Algiers, Algeria. FAU - Abdennour, Sara AU - Abdennour S AD - Department of Pharmacy, Faculty of Medicine, University of Setif 1, Setif, Algeria. FAU - Zebbiche, Younes AU - Zebbiche Y AUID- ORCID: 0000-0002-1427-8025 AD - Department of Pharmacy, Faculty of Pharmacy, University of Medical Sciences, Algiers, Algeria. LA - eng PT - Journal Article DEP - 20260902 PL - England TA - Food Addit Contam Part B Surveill JT - Food additives & contaminants. Part B, Surveillance JID - 101317183 SB - IM OTO - NOTNLM OT - Algeria OT - Organochlorine pesticides OT - animal-derived food OT - cow's milk OT - health risk assessment OT - honey OT - poultry eggs EDAT- 2026/09/03 01:13 MHDA- 2026/09/03 01:13 CRDT- 2026/09/02 12:01 PHST- 2026/09/03 01:13 [medline] PHST- 2026/09/03 01:13 [pubmed] PHST- 2026/09/02 12:01 [entrez] AID - 10.1080/19393210.2026.2714426 [doi] PST - aheadofprint SO - Food Addit Contam Part B Surveill. 2026 Sep 2:1-13. doi: 10.1080/19393210.2026.2714426. PMID- 42684076 OWN - NLM STAT- Publisher LR - 20260902 IS - 1541-3144 (Electronic) IS - 0194-2638 (Linking) DP - 2026 Sep 2 TI - Engagement of Children with Moderate and High Support Needs Autism in Motor Program Sessions. PG - 1-19 LID - 10.1080/01942638.2026.2722992 [doi] AB - AIMS: This study examined engagement during one-on-one motor program sessions for children with moderate and high support needs (MHS) autism by: (1) systematically coding child behaviors as on-task or off-task, and (2) exploring therapist-reported strategies to facilitate engagement. METHODS: Nine children (4-10 years) with MHS autism participated in a 13 week, twice-weekly motor program. All sessions were video recorded. A bespoke observational coding system was developed to measure gross motor skill practice, achieving interrater reliability (ICC = 0.927). A stratified sample of 27 sessions was coded. Eleven exercise physiologists completed semi-structured interviews at two timepoints, analyzed using reflexive thematic analysis. RESULTS: Children spent an average of 29.6% of session time in motor skill practice. Off-task periods involved sensory-seeking, co-regulation, avoidance, and exploratory or social behaviors. Interview analysis identified one overarching theme-attuning to the child-with subthemes describing the importance of the therapeutic relationship and prioritizing the child's needs. Sessions were adapted according to each child's cues, communication style, and regulatory needs. CONCLUSIONS: Findings highlight the central role of relational and regulatory processes in supporting engagement for children with MHS autism and emphasize the need for further research on mechanisms of change and therapists' moment-to-moment decision-making. FAU - Svensson, Lee AU - Svensson L AUID- ORCID: 0000-0001-5971-783X AD - School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. AD - Health and Wellbeing Centre for Research Innovation, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. FAU - Stylianou, Michalis AU - Stylianou M AUID- ORCID: 0000-0002-5905-8229 AD - School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. FAU - Hill, Jessica AU - Hill J AUID- ORCID: 0000-0003-2650-455X AD - School of Health and Rehabilitation Sciences, The University of Queensland, St Lucia, Australia. FAU - Wilson, Lucille AU - Wilson L AUID- ORCID: 0000-0003-0993-7302 AD - School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. AD - Health and Wellbeing Centre for Research Innovation, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. FAU - Trost, Stewart G AU - Trost SG AUID- ORCID: 0000-0001-9587-3944 AD - School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. FAU - Cairney, John AU - Cairney J AUID- ORCID: 0000-0003-2856-3967 AD - School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. AD - Health and Wellbeing Centre for Research Innovation, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. AD - Queensland Centre for Olympic and Paralympic Studies, School of Human Movement and Nutrition Sciences, The University of Queensland, Brisbane, Australia. LA - eng PT - Journal Article DEP - 20260902 PL - England TA - Phys Occup Ther Pediatr JT - Physical & occupational therapy in pediatrics JID - 8109120 SB - IM OTO - NOTNLM OT - Autism OT - children OT - engagement OT - motor skills OT - therapists EDAT- 2026/09/02 11:38 MHDA- 2026/09/02 11:38 CRDT- 2026/09/02 10:48 PHST- 2026/09/02 11:38 [medline] PHST- 2026/09/02 11:38 [pubmed] PHST- 2026/09/02 10:48 [entrez] AID - 10.1080/01942638.2026.2722992 [doi] PST - aheadofprint SO - Phys Occup Ther Pediatr. 2026 Sep 2:1-19. doi: 10.1080/01942638.2026.2722992. PMID- 42683142 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260902 LR - 20260903 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 8 DP - 2026 Aug TI - Quality Assessment of Complementary Feeding (CF) Practices Using CF Index and Determining Its Association With Sociodemographic Factors Among Children Aged 6-23 Months in District Etawah, Uttar Pradesh, India: A Community-Based Cross-Sectional Study. PG - e113808 LID - 10.7759/cureus.113808 [doi] LID - e113808 AB - BACKGROUND: Achieving nutritionally sufficient and well-timed supplementary feeding is central to sustaining physical growth, brain maturation, and immunological competence in infants and toddlers from 6 through 23 months. The Complementary Feeding Index (CFI) functions as an integrated multi-component instrument designed to quantify the overall adequacy of young child nutrition at the household level. OBJECTIVE: This investigation sought to appraise complementary feeding adequacy via the CFI and explore its associations with sociodemographic characteristics among children between 6 and 23 months of age in Etawah district, Uttar Pradesh, India. METHODS: This community-based cross-sectional analytical study recruited 416 children aged 6-23 months across rural and urban localities of Etawah district between January 2024 and February 2026. Household data were obtained through a validated, pre-piloted structured interview tool. CFI sub-indicators were evaluated: breastfeeding continuation, bottle use, age-appropriateness of complementary food introduction, dietary variety, food group coverage, and meal frequency. Anthropometric indices were measured with calibrated instruments, and all data were processed in Statistical Product and Service Solutions (SPSS, version 26.0; IBM SPSS Statistics for Windows, Armonk, NY). RESULTS: Breastfeeding was ongoing in 70.9% of children; 35.6% were bottle-fed. Supplementary foods at the recommended six-month milestone were given in 52.2% of cases. Minimum dietary diversity (MDD) was met by 22.1%, minimum meal frequency (MMF) by 59.4%, and minimum acceptable diet (MAD) by only 13.9%. Overall, CFI classification placed 43% of children in the appropriate and 57% in the inappropriate feeding category. CONCLUSION: Supplementary feeding quality in Etawah district is far below recommended thresholds, with 57% the children unable to achieve adequate dietary diversity or a MAD. Sustained investment in nutrition counselling, frontline workforce skill-building, and locally tailored community programmes is essential to reverse these deficits and improve child nutrition. CI - Copyright (c) 2026, Prajapati et al. FAU - Prajapati, Balram AU - Prajapati B AD - Community Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, IND. FAU - Maurya, Adarsh AU - Maurya A AD - Community Medicine, Uma Nath Singh Autonomous State Medical College, Jaunpur, IND. FAU - Prajapati, Neelam AU - Prajapati N AD - Physical Medicine and Rehabilitation, King George's Medical University (KGMU), Lucknow, IND. FAU - Rani, Vidya AU - Rani V AD - Community Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, IND. FAU - Singh, Naresh P AU - Singh NP AD - Community Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, IND. FAU - Jain, Pankaj AU - Jain P AD - Community Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, IND. FAU - Kaur, Gagan AU - Kaur G AD - Community Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, IND. FAU - Shukla, Sushil AU - Shukla S AD - Community Medicine, Uttar Pradesh University of Medical Sciences (UPUMS), Saifai, IND. LA - eng PT - Journal Article DEP - 20260802 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13532554 OTO - NOTNLM OT - complementary feeding OT - complementary feeding index OT - dietary diversity OT - infant and young child feeding OT - malnutrition COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee, Uttar Pradesh University of Medical Sciences, Saifai, Etawah (U.P.) issued approval 45/Cert./ICE/UPUMS/2024-2025. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/09/02 11:39 MHDA- 2026/09/02 11:40 PMCR- 2026/08/02 CRDT- 2026/09/02 09:01 PHST- 2026/07/31 00:00 [accepted] PHST- 2026/09/02 11:40 [medline] PHST- 2026/09/02 11:39 [pubmed] PHST- 2026/09/02 09:01 [entrez] PHST- 2026/08/02 00:00 [pmc-release] AID - 10.7759/cureus.113808 [doi] PST - epublish SO - Cureus. 2026 Aug 2;18(8):e113808. doi: 10.7759/cureus.113808. eCollection 2026 Aug. PMID- 42682778 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260902 LR - 20260903 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Exploring the impact of DEP on pediatric Crohn's disease using machine learning and molecular docking methods. PG - 1810586 LID - 10.3389/fped.2026.1810586 [doi] LID - 1810586 AB - BACKGROUND: Diethyl phthalate (DEP) is a prevalent plasticizer with multiple toxic effects and high bioavailability in humans, especially children. Pediatric Crohn's disease (PCD) is a severe chronic intestinal inflammatory disorder with a rising incidence worldwide. To date, the potential associative relationship between DEP exposure and PCD pathogenesis remains inadequately clarified, lacking systematic transcriptomic and experimental exploration. METHODS: In this study, bioinformatics analysis was performed based on 682 PCD samples and 127 normal samples retrieved from multiple GEO datasets. A series of analytical strategies including differential expression analysis, weighted gene co-expression network analysis (WGCNA), compound target prediction, functional enrichment analysis, machine learning modeling, and molecular docking simulation were comprehensively utilized, followed by preliminary animal validation. All analyses in this study focused on exploring statistical correlation rather than causal relationships, given the absence of individual DEP exposure data and inherent methodological limitations. RESULTS: Through differential analysis and WGCNA, 24 differentially expressed genes and 194 chemical targets from ChEMBL were obtained, among which 14 overlapping genes were identified. GO and KEGG analyses indicated that DEP may contribute to PCD toxicity by regulating nucleotide synthesis and amino acid metabolism. Five core genes were screened via machine learning and SHAP analysis. Animal experiments verified that PLAU protein expression in DEP, TNBS, and DEP + TNBS groups was notably higher than in the control colon tissue. CONCLUSION: This study systematically explores the potential associative links between DEP-related molecular dysregulation and PCD pathological alterations at the transcriptomic and tissue levels. The findings provide preliminary scientific references for understanding DEP-associated pediatric intestinal health risks and developing targeted preventive strategies for children's environmental health protection. CI - (c) 2026 Zhang, Ji, Ma and Chen. FAU - Zhang, Lei AU - Zhang L AD - Department of Gastroenterology, Donghai County People's Hospital, Lianyungang, China. FAU - Ji, Xingyu AU - Ji X AD - Department of Gastroenterology, Donghai County People's Hospital, Lianyungang, China. FAU - Ma, Su AU - Ma S AD - Department of Gastroenterology, The Third Affiliated Hospital of Dali University, Dali, China. FAU - Chen, Huimin AU - Chen H AD - Department of Gastroenterology, Donghai County People's Hospital, Lianyungang, China. LA - eng PT - Journal Article DEP - 20260818 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13529756 OTO - NOTNLM OT - Crohn's disease OT - diethyl phthalate OT - machine learning OT - molecular docking OT - pediatric COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/02 11:39 MHDA- 2026/09/02 11:40 PMCR- 2026/08/18 CRDT- 2026/09/02 07:40 PHST- 2026/02/13 00:00 [received] PHST- 2026/06/10 00:00 [revised] PHST- 2026/07/17 00:00 [accepted] PHST- 2026/09/02 11:40 [medline] PHST- 2026/09/02 11:39 [pubmed] PHST- 2026/09/02 07:40 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - 10.3389/fped.2026.1810586 [doi] PST - epublish SO - Front Pediatr. 2026 Aug 18;14:1810586. doi: 10.3389/fped.2026.1810586. eCollection 2026. PMID- 42682592 OWN - NLM STAT- Publisher LR - 20260903 IS - 2574-2272 (Electronic) IS - 2096-3726 (Print) IS - 2574-2272 (Linking) DP - 2026 Aug 31 TI - The role of tryptophan hydroxylase-1 in metabolic dysfunction-associated steatotic liver disease. LID - 10.1002/ped4.70078 [doi] AB - IMPORTANCE: Metabolic dysfunction-associated steatotic liver disease (MASLD) is caused by dysregulated lipid metabolism, inflammation, and mitochondrial dysfunction. Given the rising burden of MASLD in children and adolescents, identifying experimentally tractable mechanisms relevant to pediatric diseases is of considerable interest. Tryptophan hydroxylase-1 (TPH1), the rate-limiting enzyme for peripheral serotonin synthesis, has been implicated in metabolic disorders, but its hepatic role in MASLD remains unclear. OBJECTIVE: To investigate whether Tph1 suppression alleviates lipid accumulation, mitochondrial dysfunction, and hepatocyte injury through changes associated with Parkin-mediated mitophagy. METHODS: MASLD was induced in young adult male C57BL/6J mice by a 12-week high-fat diet (HFD). At HFD onset, mice received a single tail-vein injection of liver-tropic AAV8-shTph1 or the control AAV8. The HFD feeding was continued for 12 weeks until the end of the experiment. Hepatic histology, serum biochemistry, oxidative stress, inflammatory responses, apoptosis, and mitochondrial function were also evaluated. Mechanistic studies were conducted in palmitic acid/oleic acid-treated AML12 hepatocytes using siRNA targeting Tph1 and Parkin. RESULTS: Hepatic TPH1 expression was elevated in MASLD mice. Tph1 knockdown alleviated diet-induced steatosis, reduced serum triglycerides, total cholesterol, low-density lipoprotein cholesterol, and transaminase levels, suppressed oxidative stress, and attenuated inflammatory and fibrotic markers. Tph1 silencing decreased hepatocyte apoptosis and restored mitochondrial function. Transmission electron microscopy and fractionated Western blotting analyses revealed increased Parkin-associated mitophagy. In AML12 cells, siTph1 reduced lipid accumulation and apoptosis, whereas co-silencing Parkin partially reversed these effects. INTERPRETATION: Hepatic TPH1 is associated with MASLD progression and impaired Parkin-mediated mitophagy. Tph1 suppression may represent a potential therapeutic strategy for experimental MASLD, with possible translational relevance to pediatric MASLD, though direct clinical validation is still needed. CI - (c) 2026 The Author(s). Pediatric Investigation published by John Wiley & Sons Australia, Ltd on behalf of Futang Research Center of Pediatric Development. FAU - Jia, Shuangzhen AU - Jia S AUID- ORCID: 0000-0002-3163-7595 AD - Department of Gastroenterology, Hepatology and Nutrition Center, Beijing Children's Hospital, Capital Medical University National Center for Children's Health Beijing China. FAU - Ye, Xiaolin AU - Ye X AD - Department of Gastroenterology, Hepatology and Nutrition Center, Beijing Children's Hospital, Capital Medical University National Center for Children's Health Beijing China. FAU - Wang, Zhaoxia AU - Wang Z AD - Department of Gastroenterology Shenzhen Children's Hospital Shenzhen China. FAU - Wu, Jie AU - Wu J AD - Department of Gastroenterology, Hepatology and Nutrition Center, Beijing Children's Hospital, Capital Medical University National Center for Children's Health Beijing China. LA - eng PT - Journal Article DEP - 20260831 PL - United States TA - Pediatr Investig JT - Pediatric investigation JID - 101731527 PMC - PMC13529607 OTO - NOTNLM OT - Children OT - Metabolic dysfunction-associated steatotic liver disease (MASLD) OT - Parkin-dependent mitophagy OT - Tryptophan hydroxylase-1 (TPH1) COIS- The authors declare no conflict of interest. EDAT- 2026/09/02 11:39 MHDA- 2026/09/02 11:39 PMCR- 2026/08/31 CRDT- 2026/09/02 06:32 PHST- 2026/03/22 00:00 [received] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/09/02 11:39 [medline] PHST- 2026/09/02 11:39 [pubmed] PHST- 2026/09/02 06:32 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - PED470078 [pii] AID - 10.1002/ped4.70078 [doi] PST - aheadofprint SO - Pediatr Investig. 2026 Aug 31:10.1002/ped4.70078. doi: 10.1002/ped4.70078. PMID- 42682444 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260902 LR - 20260903 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Physical activity relates to adolescent social anxiety: evidence from a structural equation model involving resilience and self-efficacy. PG - 1862222 LID - 10.3389/fpsyg.2026.1862222 [doi] LID - 1862222 AB - BACKGROUND: Physical activity is consistently associated with reduced anxiety in adolescents, yet the psychological mechanisms underlying this association remain unclear. This study examined whether resilience and self-efficacy independently and sequentially mediated the association between physical activity and social anxiety. METHODS: A cross-sectional design was used with 986 Chinese adolescents. Physical activity, resilience, self-efficacy, and social anxiety were assessed using validated scales (PARS-3, CD-RISC, GSES, and SASC). Structural equation modeling was conducted in R, and indirect effects were tested using bias-corrected bootstrap procedures with 5,000 resamples. RESULTS: Physical activity was significantly associated with lower social anxiety both directly (beta = -0.420, p < 0.001) and indirectly. The indirect association through resilience was significant [beta = -0.049, 95% CI [-0.064, -0.035]], whereas the indirect effect through self-efficacy and the serial mediation pathway were not significant. Absolute fit indices were acceptable (RMSEA = 0.064, SRMR = 0.073), but the incremental fit indices fell below conventional thresholds (CFI = 0.805, TLI = 0.796); the structural estimates should therefore be interpreted with corresponding caution. CONCLUSIONS: These findings are consistent with a model in which resilience functions as a proximal correlate linking physical activity to lower social anxiety, whereas general self-efficacy did not emerge as a significant mediator in this cross-sectional sample. Given the study design and the modest incremental fit of the model, these pathways should be read as theoretically plausible associations rather than causal effects. The results nonetheless underscore the potential value of fostering resilience within physical activity interventions, and they identify longitudinal designs and domain-specific efficacy measures as priorities for future research. CI - Copyright (c) 2026 Wang, Chen, Li, Yang, Chen, Shi, Lv and Lipowski. FAU - Wang, Ning AU - Wang N AD - Department of Physical Education, Lanzhou Institute of Technology, Lanzhou, Gansu, China. FAU - Chen, Ye AU - Chen Y AD - School of Business, China West Normal University, Nanchong, China. FAU - Li, Mengmeng AU - Li M AD - Chongqing Metropolitan College of Science and Technology, Chongqing, China. FAU - Yang, Jifan AU - Yang J AD - Jinding First Primary School, Zhuhai High tech Zone, Zhuhai, China. FAU - Chen, Fangting AU - Chen F AD - Jingyang Primary School, Zhuhai High tech Zone, Zhuhai, China. FAU - Shi, Yijie AU - Shi Y AD - Gdansk University of Physical Education and Sport, Gdansk, Poland. FAU - Lv, Rujun AU - Lv R AD - Zhongshan University Affiliated Houhuan Primary School in the High-tech Zone of Zhuhai City, Zhuhai, China. FAU - Lipowski, Mariusz AU - Lipowski M AD - WSB Merito University in Gdansk, Gdansk, Poland. LA - eng PT - Journal Article DEP - 20260818 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13529522 OTO - NOTNLM OT - adolescents OT - physical activity OT - resilience OT - self-efficacy OT - social anxiety COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/02 11:39 MHDA- 2026/09/02 11:40 PMCR- 2026/08/18 CRDT- 2026/09/02 05:23 PHST- 2026/04/22 00:00 [received] PHST- 2026/07/17 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/09/02 11:40 [medline] PHST- 2026/09/02 11:39 [pubmed] PHST- 2026/09/02 05:23 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1862222 [doi] PST - epublish SO - Front Psychol. 2026 Aug 18;17:1862222. doi: 10.3389/fpsyg.2026.1862222. eCollection 2026. PMID- 42681656 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260923 IS - 1479-5876 (Electronic) IS - 1479-5876 (Linking) VI - 24 IP - 1 DP - 2026 Aug 31 TI - Human milk microbiome as a modulator of the early-life gut-brain axis: mechanisms and translational opportunities for neurodevelopment. LID - 10.1186/s12967-026-08844-1 [doi] LID - 1125 AB - The first 1000 days of life represent a critical developmental window during which early microbial colonization contributes to immune, metabolic, and neurodevelopmental programming. Human milk is increasingly recognized as a biologically active fluid that shapes infant gut microbiome assembly through microorganisms, human milk oligosaccharides (HMOs), immune factors, and microbial metabolites. Within this framework, the human milk microbiome has emerged as a potential contributor to the milk-gut-brain axis (MGBA), a bidirectional communication network linking the gut microbiota with neural, immune, endocrine, and metabolic pathways involved in brain development. This review summarizes current evidence regarding the origins, determinants, and functional relevance of the human milk microbiome and its potential role in early-life neurodevelopment. Proposed microbial sources include maternal skin, the infant oral cavity, environmental exposure, and the entero-mammary pathway, while key determinants include lactational stage, delivery mode, antibiotic exposure, maternal diet, obesity, and prematurity. Mechanistic pathways linking milk-associated microbes with neurodevelopment are discussed, including microbial colonization, immune and barrier maturation, vagal and neuroendocrine signalling, and production of short-chain fatty acids (SCFAs) and tryptophan-derived metabolites. We further evaluate evidence relating breastfeeding and milk-associated microbial exposures to cognitive, behavioural, and neurodevelopmental outcomes, particularly in preterm and medically vulnerable infants. Although experimental and observational evidence supports biologically plausible links between the human milk microbiome and the developing microbiota-gut-brain axis, major uncertainties remain regarding microbial viability, sustained colonization, causality, and long-term functional significance. Methodological limitations, including low microbial biomass, contamination susceptibility, and heterogeneity in analytical approaches, continue to complicate interpretation across studies. Future progress will require longitudinal, mechanistically informed studies integrating microbiome profiling with metabolomics, immune phenotyping, neuroimaging, and validated neurodevelopmental outcomes. CI - (c) 2026. The Author(s). FAU - Alnuaimi, Fatima AU - Alnuaimi F AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Yassin, Lidya K AU - Yassin LK AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Alketbi, Salma AU - Alketbi S AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Skrabulyte-Barbulescu, Jurga AU - Skrabulyte-Barbulescu J AD - The Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King s College London, London, UK. FAU - Almazrouei, Saif AU - Almazrouei S AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Alremeithi, Dana AU - Alremeithi D AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Alahbabi, Noud AU - Alahbabi N AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Almarzooqi, Sultan AU - Almarzooqi S AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Alkuwaiti, Shamma H AU - Alkuwaiti SH AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Hamad, Mohammad I K AU - Hamad MIK AUID- ORCID: 0000-0002-7413-0305 AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. m.hamad@uaeu.ac.ae. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20260831 PL - England TA - J Transl Med JT - Journal of translational medicine JID - 101190741 SB - IM EIN - J Transl Med. 2026 Sep 15;24(1):1184. doi: 10.1186/s12967-026-08990-6. PMID: 42745312 MH - Humans MH - *Milk, Human/microbiology MH - *Neurodevelopment MH - *Brain/growth & development MH - *Gastrointestinal Microbiome MH - *Translational Research, Biomedical MH - *Microbiota MH - Infant, Newborn MH - *Translational Science, Biomedical PMC - PMC13536827 OTO - NOTNLM OT - Breastfeeding OT - Human milk microbiome OT - Human milk oligosaccharides OT - Infant gut microbiota OT - Microbial metabolites OT - Milk-gut-brain axis OT - Neurodevelopment OT - Preterm infants COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interest. EDAT- 2026/09/02 05:36 MHDA- 2026/09/02 05:37 PMCR- 2026/08/31 CRDT- 2026/09/02 01:17 PHST- 2026/05/22 00:00 [received] PHST- 2026/08/13 00:00 [accepted] PHST- 2026/09/02 05:37 [medline] PHST- 2026/09/02 05:36 [pubmed] PHST- 2026/09/02 01:17 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - 10.1186/s12967-026-08844-1 [pii] AID - 8844 [pii] AID - 10.1186/s12967-026-08844-1 [doi] PST - epublish SO - J Transl Med. 2026 Aug 31;24(1):1125. doi: 10.1186/s12967-026-08844-1. PMID- 42681548 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260904 IS - 1541-4337 (Electronic) IS - 1541-4337 (Linking) VI - 25 IP - 5 DP - 2026 Sep TI - A Comprehensive Review of Fucosylated Human Milk Oligosaccharides: Biological Functions, Production Technologies, and Safety Regulation With Commercial Translation in Infant Nutrition. PG - e70636 LID - 10.1111/1541-4337.70636 [doi] LID - e70636 AB - Human milk oligosaccharides (HMOs) are important functional bioactive components of human milk. Fucosylated HMOs (FHMOs) represent a major subclass, accounting for approximately 35%-50% of total HMOs, and have attracted increasing attention in infant nutrition and health. Current evidence indicates that FHMOs play important roles in shaping the infant gut microbiota, modulating host-microbe interactions, supporting intestinal barrier function, and maintaining immune and metabolic homeostasis. However, their commercialization still faces several challenges, including high production costs, difficulties in the scalable manufacture of structurally complex members, uneven functional evidence across individual compounds, incomplete safety and regulatory evaluation frameworks, and the need to further validate processing stability and application performance in final products. From an industrial perspective, microbial fermentation has become the main production route for 2'-fucosyllactose and 3-fucosyllactose, whereas the large-scale production of more structurally complex or low-abundance FHMOs remains technically and economically challenging. Regulatory approvals in major markets indicate acceptable safety at authorized use levels, but uncertainties remain regarding long-term intake, vulnerable infant populations, matrix-dependent stability, and the combined use of multiple HMOs. This review summarizes recent advances in the structural characteristics, biological functions, production technologies, safety assessment, regulatory status, and commercial applications of FHMOs, with emphasis on 2'-fucosyllactose, 3-fucosyllactose, and selected structurally related members. It also discusses commercialization challenges and future research priorities to support their responsible application in infant nutrition. CI - (c) 2026 Institute of Food Technologists(R). FAU - Xu, Jinghong AU - Xu J AUID- ORCID: 0009-0000-8544-5794 AD - China-Hungary Belt and Road Joint Laboratory on Food Science, Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, College of Food Science, Southwest University, Chongqing, China. FAU - Li, Bowen AU - Li B AUID- ORCID: 0000-0002-4199-7164 AD - China-Hungary Belt and Road Joint Laboratory on Food Science, Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, College of Food Science, Southwest University, Chongqing, China. FAU - Xu, Huajian AU - Xu H AD - China-Hungary Belt and Road Joint Laboratory on Food Science, Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, College of Food Science, Southwest University, Chongqing, China. FAU - Zhang, Qing AU - Zhang Q AD - China-Hungary Belt and Road Joint Laboratory on Food Science, Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, College of Food Science, Southwest University, Chongqing, China. FAU - Li, Zheng AU - Li Z AD - China-Hungary Belt and Road Joint Laboratory on Food Science, Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, College of Food Science, Southwest University, Chongqing, China. FAU - Zhong, Xiaocui AU - Zhong X AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Qiao, Dongling AU - Qiao D AUID- ORCID: 0000-0003-1831-422X AD - China-Hungary Belt and Road Joint Laboratory on Food Science, Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, College of Food Science, Southwest University, Chongqing, China. FAU - Han, Ting-Li AU - Han TL AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Zhang, Binjia AU - Zhang B AUID- ORCID: 0009-0007-0104-571X AD - China-Hungary Belt and Road Joint Laboratory on Food Science, Chongqing Key Laboratory of Speciality Food Co-Built by Sichuan and Chongqing, College of Food Science, Southwest University, Chongqing, China. LA - eng GR - SWU-KQ25008/Fundamental Research Funds for the Central Universities/ GR - CSTB2024TIAD-KPX0014/Chongqing Technology Innovation and Application Development Special Key Project/ PT - Journal Article PT - Review PL - United States TA - Compr Rev Food Sci Food Saf JT - Comprehensive reviews in food science and food safety JID - 101305205 RN - 0 (Oligosaccharides) RN - 28RYY2IV3F (Fucose) SB - IM MH - Humans MH - *Milk, Human/chemistry MH - *Oligosaccharides/chemistry MH - *Infant Nutritional Physiological Phenomena MH - Infant MH - Fermentation MH - Food Safety MH - Fucose/chemistry PMC - PMC13534321 OTO - NOTNLM OT - fucosylated glycans OT - human milk oligosaccharides OT - infant formula OT - microbial fermentation OT - regulatory science OT - safety assessment COIS- The authors declare no conflicts of interest. EDAT- 2026/09/02 05:36 MHDA- 2026/09/02 05:37 PMCR- 2026/09/02 CRDT- 2026/09/02 00:49 PHST- 2026/08/01 00:00 [revised] PHST- 2026/06/15 00:00 [received] PHST- 2026/08/13 00:00 [accepted] PHST- 2026/09/02 05:37 [medline] PHST- 2026/09/02 05:36 [pubmed] PHST- 2026/09/02 00:49 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - CRF370636 [pii] AID - 10.1111/1541-4337.70636 [doi] PST - ppublish SO - Compr Rev Food Sci Food Saf. 2026 Sep;25(5):e70636. doi: 10.1111/1541-4337.70636. PMID- 42680256 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260901 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 124 IP - 3 DP - 2026 Sep TI - Low-burden metrics for monitoring healthy diets among nonpregnant females aged 15 to 49 years: a multicountry validation analysis using quantitative 24-hour dietary intake data. PG - 101387 LID - S0002-9165(26)00196-6 [pii] LID - 10.1016/j.ajcnut.2026.101387 [doi] AB - BACKGROUND: Limited nationally representative quantitative dietary intake data and a lack of consensus on lower-burden tools and metrics hinder high-frequency monitoring of healthy diets globally. OBJECTIVES: This study aimed to evaluate the comparative construct validity and potential complementarity of low-burden metrics of a healthy diet among nonpregnant females aged 15 to 49 y. METHODS: Quantitative 24-h dietary intake data collected from 77,118 adolescent and adult females across 27 countries were used to construct low-burden metrics and reference metrics of dietary intake. Associations between mean-standardized low-burden measures or indicators and reference metrics were assessed using linear and logistic mixed-effect models, with Spearman's rho used for survey-level rank correlations. Test characteristics identified low-burden indicators best differentiated adherence to reference indicators. RESULTS: An indicator reflecting nonconsumption of sweet foods and/or sweet beverages was most robustly associated with greater adherence to <10% energy from free sugars in upper-middle-income countries odds ratio [OR] [95% confidence interval (CI)]: 5.35 [5.05, 5.66]. Food group diversity score (FGDS) was most strongly associated with and differentiated higher mean adequacy ratio of micronutrients [beta of 1-standard deviation (SD) change: approximately 11 percentage points (9, 12); rho: 0.79], whereas noncommunicable disease-Protect score best reflected consumption of >/=400 g/d of fruits and vegetables [range OR of 1-SD changes (95% CI): 2.56-3.01 (2.40, 3.13) in lower-middle and high-income countries, respectively; rho: 0.56]. FGDS and Global Diet Quality Score Positive were most consistently associated with achieving >/=25 g/d of fiber and >/=3510 mg/d of potassium across contexts. CONCLUSIONS: Low-burden data collection tools yield valid metrics, enabling high-frequency monitoring of healthy diets across contexts. Specifically, avoiding sweet foods and/or sweet beverages is an indicator for adherence to WHO free sugar guidelines among nonpregnant females in upper-middle-income countries, whereas metrics reflecting nutritious food group diversity strongly reflect better micronutrient adequacy and adherence to WHO guidelines for fruits and vegetables, fiber, and potassium intakes within and across contexts. CI - Copyright (c) 2026 Food and Agriculture Organization of the United Nations,. Published by Elsevier Inc. All rights reserved. FAU - Hanley-Cook, Giles T AU - Hanley-Cook GT AD - Food and Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy. Electronic address: giles.hanleycook@fao.org. FAU - Frongillo, Edward A AU - Frongillo EA AD - Department of Health Promotion, Education, and Behaviour, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States. FAU - Sattamini, Isabela Fleury AU - Sattamini IF AD - Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. FAU - Ingenbleek, Luc AU - Ingenbleek L AD - Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. FAU - Coates, Jennifer C AU - Coates JC AD - The Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States. FAU - Holmes, Bridget A AU - Holmes BA AD - Food and Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy. CN - Healthy Diets Monitoring Initiative (HDMI) LA - eng PT - Journal Article PT - Validation Study DEP - 20260813 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - Female MH - *Diet, Healthy MH - Adolescent MH - Adult MH - Young Adult MH - Middle Aged MH - Energy Intake MH - Diet Surveys OTO - NOTNLM OT - GDQS OT - MDD-W OT - UPF OT - construct validity OT - dietary diversity OT - healthy diets OT - macronutrient balance OT - moderation OT - monitoring OT - nutrient adequacy COIS- Conflict of interest EF is a member of the Statistical Review Board of the American Society for Nutrition. The authors report no conflicts of interest. FIR - Aguayo, Victor IR - Aguayo V IRAD- Data and Analytics Section, Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, United States. FIR - Branca, Francesco IR - Branca F IRAD- Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. FIR - Borghi, Elaine IR - Borghi E IRAD- Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. FIR - Coates, Jennifer C IR - Coates JC IRAD- The Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States. FIR - Frongillo, Edward A IR - Frongillo EA IRAD- Department of Health Promotion, Education, and Behaviour, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States. FIR - Hanley-Cook, Giles T IR - Hanley-Cook GT IRAD- Food and Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy. FIR - Hassfurter, Karoline IR - Hassfurter K IRAD- Data and Analytics Section, Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, United States. FIR - Hayashi, Chika IR - Hayashi C IRAD- Data and Analytics Section, Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, United States. FIR - Holmes, Bridget A IR - Holmes BA IRAD- Food and Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy. FIR - Ingenbleek, Luc IR - Ingenbleek L IRAD- Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. FIR - Mehra, Vrinda IR - Mehra V IRAD- Data and Analytics Section, Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, United States. FIR - Neufeld, Lynnette M IR - Neufeld LM IRAD- Food and Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy. FIR - Saha, Kuntal IR - Saha K IRAD- Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. FIR - Sattamini, Isabella Fleury IR - Sattamini IF IRAD- Department of Nutrition and Food Safety, World Health Organization, Geneva, Switzerland. EDAT- 2026/09/01 23:34 MHDA- 2026/09/01 23:35 CRDT- 2026/09/01 20:54 PHST- 2025/09/08 00:00 [received] PHST- 2026/04/14 00:00 [revised] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/09/01 23:35 [medline] PHST- 2026/09/01 23:34 [pubmed] PHST- 2026/09/01 20:54 [entrez] AID - S0002-9165(26)00196-6 [pii] AID - 10.1016/j.ajcnut.2026.101387 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Sep;124(3):101387. doi: 10.1016/j.ajcnut.2026.101387. Epub 2026 Aug 13. PMID- 42680155 OWN - NLM STAT- Publisher LR - 20260901 IS - 1753-4887 (Electronic) IS - 0029-6643 (Linking) DP - 2026 Sep 1 TI - Validity of Nutrition Screening Tools for Risk of Malnutrition Among Pediatric Oncology Populations: A Systematic Review and Meta-Analysis. LID - nuag120 [pii] LID - 10.1093/nutrit/nuag120 [doi] AB - CONTEXT: The lack of standardized procedures for malnutrition risk screening in the pediatric oncology population. OBJECTIVE: This systematic review and meta-analysis aimed to evaluate the validity of nutritional screening tools for identifying the risk of malnutrition in pediatric oncology patients. DATA SOURCES: A systematic review of studies identified in 4 databases (Web of Science, Scopus, OVID and CINAHL) were searched from inception to April 2025. DATA EXTRACTION: Two reviewers independently screened studies, extracted data, and assessed methodological quality using the Quality Assessment of Diagnostic Accuracy Studies 2 tool. DATA ANALYSIS: Diagnostic accuracy outcomes were analyzed using a Bayesian bivariate random-effects model via MetaBayesDTA. Summary estimates were pooled where applicable, and summary receiver operating characteristic curves were generated to illustrate diagnostic performance. RESULTS: Of 1377 articles retrieved, 7 met inclusion criteria for the systematic review, and 6 were included in the pooled meta-analysis. These studies evaluated 4 different nutrition screening tools, including the Screening Tool for Childhood Cancer (SCAN), Screening Tool for Risk on Nutritional Status and Growth (STRONGkids), Pediatric Yorkhill Malnutrition Score (PYMS), and Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP). The meta-analysis evaluated the diagnostic performance of 3 nutritional risk screening tools-SCAN, STRONGkids, and PYMS-against anthropometric measurements and/or pediatric Subjective Global Nutritional Assessment (SGNA) as reference standards. SCAN demonstrated good to excellent sensitivity against body mass index (BMI; 89.0%; 95% CrI, 68.8-95.9) and SGNA (95.0%; 95% CrI, 72.9-98.9), though with poor to insufficient specificity. PYMS showed excellent sensitivity (91.0%; 95% CrI, 59.1-97.8), but poor specificity (43.3%; 95% CrI, 26.1-66.6) compared to BMI. CONCLUSION: SCAN and PYMS demonstrated high sensitivity but low specificity in identifying pediatric cancer patients at risk of malnutrition. Future research should focus on validation studies, aimed at standardizing the nutritional risk screening process in the pediatric oncology population. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration No. [CRD420251022898]. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the International Life Sciences Institute. FAU - Kangalgil, Melda AU - Kangalgil M AUID- ORCID: 0000-0003-2868-8903 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Sivas Cumhuriyet University, Sivas, 58140, Turkiye. FAU - Meral, Buket AU - Meral B AUID- ORCID: 0000-0003-1664-9333 AD - Department of Child Health and Diseases Nursing, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, 61080, Turkiye. FAU - Kucuk Erdol, Ebru AU - Kucuk Erdol E AUID- ORCID: 0000-0003-1182-7807 AD - Department of Obstetrics and Gynecology Nursing, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, 61080, Turkiye. LA - eng PT - Journal Article DEP - 20260901 PL - United States TA - Nutr Rev JT - Nutrition reviews JID - 0376405 SB - IM OTO - NOTNLM OT - cancer OT - child OT - malnutrition OT - malnutrition screening tools OT - meta-analysis OT - nutritional screening EDAT- 2026/09/01 23:34 MHDA- 2026/09/01 23:34 CRDT- 2026/09/01 19:53 PHST- 2026/09/01 23:34 [medline] PHST- 2026/09/01 23:34 [pubmed] PHST- 2026/09/01 19:53 [entrez] AID - 8778819 [pii] AID - 10.1093/nutrit/nuag120 [doi] PST - aheadofprint SO - Nutr Rev. 2026 Sep 1:nuag120. doi: 10.1093/nutrit/nuag120. PMID- 42679805 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260922 IS - 2666-3791 (Electronic) IS - 2666-3791 (Linking) VI - 7 IP - 9 DP - 2026 Sep 15 TI - Maternal secretor status and human milk oligosaccharides influence the infant gut resistome. PG - 103007 LID - S2666-3791(26)00424-6 [pii] LID - 10.1016/j.xcrm.2026.103007 [doi] LID - 103007 AB - The infant gut resistome is established early in life and is shaped by perinatal exposures, yet the mechanisms underlying its modulation remain unclear. We combined shotgun metagenomics of fecal samples from 57 one-month-old infants and paired milk samples from 50 mothers in the MAMI cohort to investigate the influence of maternal secretor status on early-life resistome development. Longitudinal follow-up at 6 and 12 months, and also further validation in the independent Lifelines NEXT (LLNEXT) cohort, support our findings. Cesarean section (C-section) was associated with increased antibiotic resistance gene (ARG) diversity, whereas exclusive breastfeeding reduced ARG abundance and diversity. Maternal secretor status further modified resistome composition among exclusively breastfed infants. Human milk oligosaccharide profiling identified specific glycans underlying these associations, with 2'-fucosyllactose and 6'-sialyllactose showing negative correlations with distinct ARG classes. These findings identify human milk composition as a key determinant of early-life resistome assembly and a potential target for modulating antimicrobial resistance. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Samarra, Anna AU - Samarra A AD - Department of Biotechnology, Institute of Agrochemistry and Food Technology- National Research Council (IATA-CSIC), Paterna, Valencia, Spain; Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Mother-Milk-Infant Center of Research Excellence, University of California, San Diego, La Jolla, CA 92093, USA. Electronic address: asamarramas@health.ucsd.edu. FAU - Alcaniz, Alejandro J AU - Alcaniz AJ AD - Department of Biotechnology, Institute of Agrochemistry and Food Technology- National Research Council (IATA-CSIC), Paterna, Valencia, Spain; Institute for Agribiotechnology Research (CIALE), Department of Microbiology and Genetics, University of Salamanca, Salamanca, Spain. FAU - Quijada, Narciso M AU - Quijada NM AD - Institute of Functional Biology and Genomics (IBFG), CSIC - USAL, Salamanca, Spain. FAU - Renwick, Simone AU - Renwick S AD - Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Mother-Milk-Infant Center of Research Excellence, University of California, San Diego, La Jolla, CA 92093, USA. FAU - George, Sergio AU - George S AD - Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands; Department of Pediatrics and Pediatric Surgery (Eastern Campus), Hospital Luis Calvo Mackenna, Faculty of Medicine, Universidad de Chile, Santiago, Chile. FAU - Sinha, Trishla AU - Sinha T AD - Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. FAU - Martinez-Costa, Cecilia AU - Martinez-Costa C AD - Department of Pediatrics, School of Medicine, University of Valencia, Valencia, Spain; Pediatric Gastroenterology and Nutrition Section, Hospital Clinico Universitario Valencia, Valencia, Spain. FAU - Segata, Nicola AU - Segata N AD - Department CIBIO, University of Trento, Trento, Italy. FAU - Zhernakova, Alexandra AU - Zhernakova A AD - Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. FAU - Bode, Lars AU - Bode L AD - Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA; Mother-Milk-Infant Center of Research Excellence, University of California, San Diego, La Jolla, CA 92093, USA; Human Milk Institute, University of California, San Diego, La Jolla, CA 92093, USA. FAU - Collado, Maria Carmen AU - Collado MC AD - Department of Biotechnology, Institute of Agrochemistry and Food Technology- National Research Council (IATA-CSIC), Paterna, Valencia, Spain. Electronic address: mcolam@iata.csic.es. LA - eng PT - Journal Article DEP - 20260901 PL - United States TA - Cell Rep Med JT - Cell reports. Medicine JID - 101766894 RN - 0 (Oligosaccharides) RN - 0 (Trisaccharides) RN - XO2533XO8R (2'-fucosyllactose) RN - 0 (6'-sialyllactose) RN - J2B2A4N98G (Lactose) SB - IM MH - Humans MH - *Milk, Human/metabolism/chemistry MH - *Oligosaccharides/metabolism MH - Female MH - Infant MH - Breast Feeding MH - Feces/microbiology MH - Trisaccharides/metabolism MH - *Gastrointestinal Microbiome/genetics MH - Adult MH - Lactose/analogs & derivatives/metabolism MH - Cesarean Section MH - Drug Resistance, Microbial/genetics PMC - PMC13589485 OTO - NOTNLM OT - antibiotic resistance genes OT - breastfeeding OT - human milk oligosaccharides OT - infant resistome OT - maternal secretor status OT - microbiome OT - mode of delivery COIS- Declaration of interests The authors report there are no competing interests to declare. EDAT- 2026/09/01 23:34 MHDA- 2026/09/15 23:35 PMCR- 2026/09/01 CRDT- 2026/09/01 18:41 PHST- 2026/05/28 00:00 [received] PHST- 2026/06/25 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/09/15 23:35 [medline] PHST- 2026/09/01 23:34 [pubmed] PHST- 2026/09/01 18:41 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - S2666-3791(26)00424-6 [pii] AID - 103007 [pii] AID - 10.1016/j.xcrm.2026.103007 [doi] PST - ppublish SO - Cell Rep Med. 2026 Sep 15;7(9):103007. doi: 10.1016/j.xcrm.2026.103007. Epub 2026 Sep 1. PMID- 42677684 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260918 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 3 DP - 2026 Jul TI - Women's Experiences of Breastfeeding Beyond One Year: A Qualitative Systematic Review. PG - e70242 LID - 10.1111/mcn.70242 [doi] LID - e70242 AB - Breastfeeding beyond 1 year is recommended by the World Health Organisation and is linked to multiple maternal, infant, and environmental benefits. However, rates frequently remain low in high-income countries, which may relate to social stigma, work commitments and insufficient support. This review aimed to explore the experiences of women who breastfeed beyond 1 year. Accordingly, a qualitative systematic review following the Joanna Briggs Institute meta-aggregation approach and reported to the ENTREQ statement was undertaken. Searches were conducted in Ovid MEDLINE, Ovid EMBASE, CINAHL, and Web of Science from database inception to June 2026. Two reviewers were involved in the search, extraction, quality assessment and synthesis process. A total of 6831 articles were screened, and 36 studies were included, most of which were conducted in high-income countries. One hundred and thirty extracted findings were used to form 10 categories, which were developed into four synthesised findings: (1) society and culture impact acceptability and visibility of breastfeeding beyond 1 year; (2) structural and institutional constraints undermine breastfeeding beyond 1 year; (3) social networks and peer support influence breastfeeding beyond 1 year; and (4) breastfeeding beyond 1 year involves an interplay of bonding, empowerment, challenges, and adaptation. This review highlights the complex and often challenging contexts women face when breastfeeding beyond 1 year. Multi-level efforts to normalise and validate this practice are essential to better align with global health guidance. Future research should explore experiences of breastfeeding beyond 1 year in countries where it is more commonly practised. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Cronin, Thomas AU - Cronin T AUID- ORCID: 0000-0001-9522-3992 AD - School of Public Health, University College Cork, Cork, Ireland, Discipline of Public Health and Primary Care, School of Medicine, Trinity College Dublin, Dublin, Ireland. FAU - Ahmad, Noor Ainah Gulzar AU - Ahmad NAG AUID- ORCID: 0009-0000-2050-0721 AD - School of Medicine, Trinity College Dublin, Dublin, Ireland. FAU - McCarthy, Noel AU - McCarthy N AUID- ORCID: 0000-0003-1113-1017 AD - Discipline of Public Health and Primary Care, School of Medicine, Trinity College Dublin, Dublin, Ireland. LA - eng GR - HRBI_/Health Research Board/Ireland PT - Journal Article PT - Systematic Review PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - *Breast Feeding/psychology MH - Female MH - Social Support MH - Qualitative Research MH - *Mothers/psychology MH - Time Factors PMC - PMC13531375 OTO - NOTNLM OT - breastfeeding OT - experiences OT - qualitative OT - systematic review COIS- The authors declare no conflicts of interest. EDAT- 2026/09/01 11:39 MHDA- 2026/09/01 11:40 PMCR- 2026/09/01 CRDT- 2026/09/01 06:35 PHST- 2026/07/09 00:00 [revised] PHST- 2025/12/04 00:00 [received] PHST- 2026/07/25 00:00 [accepted] PHST- 2026/09/01 11:40 [medline] PHST- 2026/09/01 11:39 [pubmed] PHST- 2026/09/01 06:35 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - MCN70242 [pii] AID - 10.1111/mcn.70242 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jul;22(3):e70242. doi: 10.1111/mcn.70242. PMID- 42677197 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260901 LR - 20260902 IS - 2048-7177 (Print) IS - 2048-7177 (Electronic) IS - 2048-7177 (Linking) VI - 14 IP - 9 DP - 2026 Sep TI - Alterations in Human Milk Adiponectin, Leptin, Resistin, and microRNAs in Mothers With Gestational Diabetes Mellitus Compared With Healthy Controls: A Systematic Review and Network-Based Analysis. PG - e72256 LID - 10.1002/fsn3.72256 [doi] LID - e72256 AB - Gestational diabetes mellitus (GDM) is linked to poor infant metabolic outcomes, potentially via altered human milk (HM) hormones and microRNAs. Since their specific roles remain unclear, this study synthesizes current evidence on HM adipose tissue-derived hormones (particularly adiponectin, leptin, and resistin) and microRNA modifications during gestational diabetes. Firstly, a systematic review following PRISMA 2020 guidelines was conducted (PROSPERO: CRD42024612813). Searches in major databases identified studies comparing HM adiponectin, leptin, or resistin concentrations and/or miRNA profiles between GDM and normoglycemic mothers. Secondly, bioinformatics analysis using miRWalk 3.0, functional enrichment, and network topology mapping examined miRNA interactions with ADIPOQ, LEP, and RETN genes. Twelve studies were included. Adiponectin showed the most consistent GDM-associated reductions, though findings were context-dependent. Leptin was primarily associated with maternal adiposity rather than GDM status. Resistin evidence was insufficient. Three miRNA studies revealed stage-dependent dysregulation in GDM, with miR-148a, miR-30b, let-7a, and let-7d linked to infant growth outcomes during the first 6 months. Bioinformatics identified miR-148a-5p and miR-30b-3p as targeting all three adipokine genes, with enrichment in glucose homeostasis and insulin resistance pathways. Network analysis highlighted TCF7L2, INSR, GCK, and HNF1A as central nodes. GDM is associated with selective alterations in HM adipokines and miRNAs, with adiponectin and specific miRNAs showing the strongest signals. These findings support a conceptual model where GDM shapes HM's molecular composition through interacting endocrine and posttranscriptional mechanisms, potentially influencing infant metabolic programming. Larger longitudinal studies are needed to validate these observations and determine clinical relevance. CI - (c) 2026 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC. FAU - Zhang, Zhijun AU - Zhang Z AD - Hubei Key Laboratory of Diabetes and Angiopathy, School of Pharmacy Xianning Medical College, Hubei University of Science and Technology Xianning Hubei Province P. R. China. FAU - Davoudi, Maryam AU - Davoudi M AD - Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences Tehran Iran. FAU - Ghafourian, Amirreza AU - Ghafourian A AD - Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences Tehran Iran. AD - Students' Scientific Research Center Tehran University of Medical Sciences Tehran Iran. FAU - Dehghan, Parmida AU - Dehghan P AD - Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences Tehran Iran. AD - Students' Scientific Research Center Tehran University of Medical Sciences Tehran Iran. FAU - Ahmadi, Mojde AU - Ahmadi M AD - Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences Tehran Iran. AD - Students' Scientific Research Center Tehran University of Medical Sciences Tehran Iran. FAU - Ayyoubzadeh, Seyed Mohammad AU - Ayyoubzadeh SM AUID- ORCID: 0000-0001-8450-7818 AD - Department of Medical Education, School of Medicine Tehran University of Medical Sciences Tehran Iran. FAU - Miao, Xiaolei AU - Miao X AD - Hubei Key Laboratory of Diabetes and Angiopathy, School of Pharmacy Xianning Medical College, Hubei University of Science and Technology Xianning Hubei Province P. R. China. FAU - Choobineh, Hamid AU - Choobineh H AD - Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences Tehran Iran. FAU - Afrisham, Reza AU - Afrisham R AUID- ORCID: 0000-0001-8064-118X AD - Department of Medical Laboratory Sciences, School of Allied Medical Sciences Tehran University of Medical Sciences Tehran Iran. LA - eng PT - Journal Article PT - Review DEP - 20260831 PL - United States TA - Food Sci Nutr JT - Food science & nutrition JID - 101605473 PMC - PMC13528237 OTO - NOTNLM OT - body weight OT - gestational diabetes OT - hormones OT - human milk OT - infant obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/09/01 11:39 MHDA- 2026/09/01 11:40 PMCR- 2026/08/31 CRDT- 2026/09/01 06:23 PHST- 2026/02/18 00:00 [received] PHST- 2026/07/11 00:00 [revised] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/09/01 11:40 [medline] PHST- 2026/09/01 11:39 [pubmed] PHST- 2026/09/01 06:23 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - FSN372256 [pii] AID - 10.1002/fsn3.72256 [doi] PST - epublish SO - Food Sci Nutr. 2026 Aug 31;14(9):e72256. doi: 10.1002/fsn3.72256. eCollection 2026 Sep. PMID- 42676987 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260901 LR - 20260902 IS - 2352-3409 (Electronic) IS - 2352-3409 (Linking) VI - 68 DP - 2026 Aug TI - Design and manufacturing data for an infant upper body physical model for bench testing of assistive devices. PG - 113099 LID - 10.1016/j.dib.2026.113099 [doi] LID - 113099 AB - Pediatric assistive devices require rigorous preliminary testing for safety and effectiveness before conducting trials with pediatric populations. Existing upper-body physical models for infants are often prohibitively expensive; meanwhile, more affordable alternatives frequently lack anthropometric accuracy or adequate joint mobility. This paper presents design and manufacturing data for a high-fidelity model that closely mirrors the physical properties of a six-month-old infant's upper body. A comprehensive guide to the design process, manufacturing, and assembly is also included. The model consists of the torso, upper arms, forearms, and hands, connected with articulated joints. Validation of the model's segments confirms close alignment with target metrics for size, mass distribution, and joint mobility. By adjusting the design parameters, the infant model can be scaled to represent older pediatric populations. This work offers a scalable framework for researchers to develop physical models for pediatric device testing. CI - (c) 2026 The Authors. FAU - Kuo, Emily AU - Kuo E AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. FAU - Rauch, Chris AU - Rauch C AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. FAU - Macaluso, Christian AU - Macaluso C AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. FAU - Gowda, Aryan AU - Gowda A AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. FAU - Ortega, Jonathan AU - Ortega J AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. FAU - Castillo, Miriam Contreras AU - Castillo MC AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. FAU - Barahona, Melanie AU - Barahona M AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. FAU - McCarty, Tristan AU - McCarty T AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. FAU - Sahin, Ipsita AU - Sahin I AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. FAU - Kokkoni, Elena AU - Kokkoni E AD - Department of Bioengineering, University of California, 900 University Ave, Riverside, CA 92521-0001, USA. LA - eng PT - Journal Article DEP - 20260818 PL - Netherlands TA - Data Brief JT - Data in brief JID - 101654995 PMC - PMC13527506 OTO - NOTNLM OT - Additive manufacturing OT - Computer-aided design OT - Manikin EDAT- 2026/09/01 11:39 MHDA- 2026/09/01 11:40 PMCR- 2026/08/18 CRDT- 2026/09/01 06:07 PHST- 2026/03/12 00:00 [received] PHST- 2026/07/07 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/09/01 11:40 [medline] PHST- 2026/09/01 11:39 [pubmed] PHST- 2026/09/01 06:07 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - S2352-3409(26)00647-5 [pii] AID - 113099 [pii] AID - 10.1016/j.dib.2026.113099 [doi] PST - epublish SO - Data Brief. 2026 Aug 18;68:113099. doi: 10.1016/j.dib.2026.113099. eCollection 2026 Aug. PMID- 42676574 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260901 LR - 20260902 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Bibliometric analysis of research on pediatric hypothyroidism treatment: a global perspective on trends and emerging fronts (2018-2026). PG - 1908940 LID - 10.3389/fped.2026.1908940 [doi] LID - 1908940 AB - BACKGROUND: Pediatric hypothyroidism is among the most prevalent endocrine disorders in childhood, yet no bibliometric analysis has systematically mapped the research landscape of its treatment. OBJECTIVE: This study aimed to characterize the publication trends, geographic distribution, research hotspots, and emerging fronts in pediatric hypothyroidism treatment research from 2018 to 2026. METHODS: A comprehensive search was conducted in the Web of Science Core Collection (WoSCC) as the primary database, with external data validation performed via PubMed. Bibliometric indicators were analyzed using CiteSpace, Python and R. Keyword co-occurrence networks were constructed with Louvain community detection, and burst detection was performed to identify emerging research fronts. RESULTS: A total of 1,302 publications were included. Annual output grew from 138 (2018) to a peak of 183 (2022). The United States (n = 263, 20.2%), China (n = 203, 15.6%), and Italy (n = 137, 10.5%) were the leading contributors. Five thematic clusters were identified: (1) congenital hypothyroidism and neonatal screening; (2) subclinical hypothyroidism; (3) pregnancy-related thyroid disorders; (4) autoimmune thyroid disease; and (5) comorbidities and genetic syndromes. Burst detection revealed "obesity" (burst strength = 7.2), "COVID-19" (4.0), and "thyroid dyshormonogenesis" (3.2) as emerging fronts. CONCLUSIONS: The field is shifting focus from congenital hypothyroidism screening optimization toward subclinical hypothyroidism management and the recognition of obesity-related TSH elevation as a distinct physiological entity. Future research should prioritize prospective trials on watchful-waiting strategies and obesity-specific TSH reference ranges. CI - (c) 2026 Wu, Sun, Liu, Huang, Liu, Qiu and Wang. FAU - Wu, Wei AU - Wu W AD - Children's Health Section, Ganzhou Women and Children's Health Care Hospital, Ganzhou, Jiangxi, China. FAU - Sun, Zhengyun AU - Sun Z AD - Department of Radiology, Lincang First People's Hospital, Lincang, Yunnan, China. FAU - Liu, Mengxun AU - Liu M AD - Children's Health Section, Ganzhou Women and Children's Health Care Hospital, Ganzhou, Jiangxi, China. FAU - Huang, Yu AU - Huang Y AD - Children's Health Section, Ganzhou Women and Children's Health Care Hospital, Ganzhou, Jiangxi, China. FAU - Liu, Tingting AU - Liu T AD - Children's Health Section, Ganzhou Women and Children's Health Care Hospital, Ganzhou, Jiangxi, China. FAU - Qiu, Xiaobing AU - Qiu X AD - Children's Health Section, Ganzhou Women and Children's Health Care Hospital, Ganzhou, Jiangxi, China. FAU - Wang, Yuanbiao AU - Wang Y AD - Department of Colorectal Surgery, The Third Affiliated Hospital of Kunming Medical University/Yunnan Cancer Hospital, Kunming, Yunnan, China. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260817 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13526919 OTO - NOTNLM OT - congenital hypothyroidism OT - levothyroxine OT - neonatal screening OT - pediatric hypothyroidism OT - subclinical hypothyroidism COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/01 11:39 MHDA- 2026/09/01 11:40 PMCR- 2026/08/17 CRDT- 2026/09/01 05:30 PHST- 2026/06/14 00:00 [received] PHST- 2026/07/19 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/09/01 11:40 [medline] PHST- 2026/09/01 11:39 [pubmed] PHST- 2026/09/01 05:30 [entrez] PHST- 2026/08/17 00:00 [pmc-release] AID - 10.3389/fped.2026.1908940 [doi] PST - epublish SO - Front Pediatr. 2026 Aug 17;14:1908940. doi: 10.3389/fped.2026.1908940. eCollection 2026. PMID- 42676515 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260902 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Early and sex-specific dynamic changes of the modified Glasgow Prognostic Score correlate with survival and immunotoxicities in patients undergoing allogeneic hematopoietic stem cell transplantation. PG - 1894926 LID - 10.3389/fimmu.2026.1894926 [doi] LID - 1894926 AB - Risk assessment before allogeneic hematopoietic stem cell transplantation (alloHSCT) is essential to estimate treatment-related morbidity and mortality; the hematopoietic cell transplantation-comorbidity index (HCT-CI) is widely used. The modified Glasgow Prognostic Score (mGPS), reflecting systemic inflammation and nutritional status, is a validated prognostic marker in solid tumors, but ill-defined in alloHSCT. We evaluated the prognostic impact of mGPS before and early after alloHSCT on overall survival (OS), non-relapse mortality (NRM), and acute graft-versus-host disease (aGvHD). We analyzed 442 consecutive alloHSCT patients (2012-2017, University Hospital Cologne). Outcomes were assessed by mGPS pre-transplant (preTx), at day+30, and by dynamic changes (Delta(30)mGPS). Subgroup analyses included transplant characteristics and sex. Patients with mGPS 2 preTx had inferior OS (HR 2.32, p<0.0001) and NRM (HR 2.31, p=0.002). Moreover, Delta(30)mGPS changes indicated poorer OS and NRM rates more strongly (Delta(30)mGPS(1-->2vs0-->1): OS: HR 2.85, p=0.02; NRM: HR 3.99, p=0.05). Findings regarding aGvHD were conflicting. Multivariable analysis confirmed mGPS as an independent prognostic factor for survival. Sex-specific analyses revealed distinct risk patterns. These findings highlight the prognostic relevance of the immunonutritional status before and early after alloHSCT, warranting prospective studies to further validate the mGPS for refined risk stratification. CI - Copyright (c) 2026 Thurisch, Althoff, Leuchte, Shahbaz, Funk, Kirmaier, Hadzic, Oganesian, Carboniero, Vona, Geier, Muschik, Cordas dos Santos, von Bergwelt-Baildon, Holtick, Scheid and Theurich. FAU - Thurisch, Hannah AU - Thurisch H AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. AD - German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany. AD - Bavarian Cancer Research Center (BZKF), LMU University Hospital, Munich, Germany. FAU - Althoff, Kathrin C AU - Althoff KC AD - Department I of Internal Medicine, Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany. AD - Department of Otorhinolaryngology, University of Lubeck, Lubeck, Germany. FAU - Leuchte, Katharina AU - Leuchte K AD - Department I of Internal Medicine, Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany. AD - National Center for Cancer Immune Therapy (CCIT-DK), Department of Oncology, Copenhagen University Hospital Herlev, Herlev, Denmark. FAU - Shahbaz, Wajma AU - Shahbaz W AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Funk, Maximilian A AU - Funk MA AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. AD - German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany. AD - Bavarian Cancer Research Center (BZKF), LMU University Hospital, Munich, Germany. FAU - Kirmaier, Martin E AU - Kirmaier ME AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Hadzic, Amar AU - Hadzic A AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Oganesian, Sabine AU - Oganesian S AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Carboniero, Adriano AU - Carboniero A AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. AD - German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany. FAU - Vona, Ludovica AU - Vona L AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Geier, Caroline AU - Geier C AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Muschik, Lena AU - Muschik L AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - Cordas Dos Santos, David M AU - Cordas Dos Santos DM AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. FAU - von Bergwelt-Baildon, Michael AU - von Bergwelt-Baildon M AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. AD - German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany. AD - Bavarian Cancer Research Center (BZKF), LMU University Hospital, Munich, Germany. FAU - Holtick, Udo AU - Holtick U AD - Department I of Internal Medicine, Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany. FAU - Scheid, Christof AU - Scheid C AD - Department I of Internal Medicine, Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany. FAU - Theurich, Sebastian AU - Theurich S AD - Cancer and Immunometabolism Research Group, Gene Center, Ludwig-Maximilians-Universitat (LMU) Munchen, Munich, Germany. AD - Department of Medicine III and Comprehensive Cancer Center Munich, LMU University Hospital, Munich, Germany. AD - German Cancer Consortium (DKTK), Munich Site, and German Cancer Research Center, Heidelberg, Germany. AD - Bavarian Cancer Research Center (BZKF), LMU University Hospital, Munich, Germany. LA - eng PT - Journal Article DEP - 20260817 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 SB - IM MH - Humans MH - *Hematopoietic Stem Cell Transplantation/adverse effects/mortality MH - Male MH - Female MH - *Graft vs Host Disease/etiology/mortality MH - Middle Aged MH - Adult MH - Prognosis MH - Transplantation, Homologous MH - Sex Factors MH - Young Adult MH - Adolescent MH - Risk Assessment MH - Aged MH - Retrospective Studies PMC - PMC13526978 OTO - NOTNLM OT - allogeneic hematopoietic stem cell transplantation OT - graft-versus-host disease OT - immunonutritional status OT - inflammation OT - metabolism OT - risk assessment COIS- The authors declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author ST declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/09/01 11:39 MHDA- 2026/09/01 11:40 PMCR- 2026/08/17 CRDT- 2026/09/01 05:22 PHST- 2026/05/29 00:00 [received] PHST- 2026/07/25 00:00 [revised] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/09/01 11:40 [medline] PHST- 2026/09/01 11:39 [pubmed] PHST- 2026/09/01 05:22 [entrez] PHST- 2026/08/17 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1894926 [doi] PST - epublish SO - Front Immunol. 2026 Aug 17;17:1894926. doi: 10.3389/fimmu.2026.1894926. eCollection 2026. PMID- 42676383 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260901 LR - 20260902 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Association between prognostic nutritional index and complications in children with immunoglobulin A vasculitis. PG - 1853071 LID - 10.3389/fnut.2026.1853071 [doi] LID - 1853071 AB - OBJECTIVE: This study aimed to evaluate the correlation between prognostic nutritional index (PNI) and complications in immunoglobulin A vasculitis (IgAV) children, including vomiting, abdominal pain, bloody stools, and proteinuria. METHODS: A retrospective study was conducted on 732 children diagnosed with IgAV at the Xiangtan Central Hospital of the Hunan University between 2014 and 2025. Logistic regression analyses, subgroup analysis, sensitivity analysis, and receiver operating characteristic (ROC) curves were employed to evaluate the association between PNI and vomiting, abdominal pain, bloody stool, and proteinuria. RESULTS: Multivariate logistic regression analysis indicated that, each unit increase and one standard deviation (SD) increase in the PNI was associated with a 9.4% reduction (OR = 0.906) and a 50.5% reduction (OR = 0.495) in the risk of vomiting, respectively. Compared to the low PNI group, the high PNI group exhibited a 55.4% reduction in the risk of vomiting (OR = 0.446). Additionally, each unit increase and one SD increase in PNI were linked to a 6.7% (OR = 0.933) and a 38.9% (OR = 0.611) reduction in the risk of abdominal pain, respectively. Furthermore, the high PNI group demonstrated a 60.4% reduction in the risk of abdominal pain (OR = 0.396). For each unit increase and one SD increase in PNI, the risk of bloody stools decreased by 4.9% (OR = 0.951) and 30.3% (OR = 0.697), respectively. Moreover, the high PNI group exhibited a 52.2% reduction in the risk of bloody stools (OR = 0.478). Additionally, for each unit increase and one SD increase in PNI, the risk of proteinuria decreased by 6.6% (OR = 0.934) and 38.5% (OR = 0.615), respectively. Compared to the low PNI group, the high PNI group exhibited a 47.0% reduction in the risk of proteinuria (OR = 0.530). And Most subgroup and sensitivity analyses confirmed the stability of the results (p < 0.05). ROC analysis indicated that PNI was significantly correlated with vomiting, abdominal pain, bloody stools, and proteinuria (p < 0.05). CONCLUSION: Higher levels of PNI were significantly associated with a lower risk of vomiting, abdominal pain, bloody stools, and proteinuria in IgAV children. CI - Copyright (c) 2026 Xiong, Liu, Li, Zhou and Yu. FAU - Xiong, Xiao AU - Xiong X AD - Department of Pediatrics, Xiangtan Central Hospital Affiliated to Hunan University, Xiangtan, China. FAU - Liu, Zezheng AU - Liu Z AD - Department of Pediatrics, Xiangtan Central Hospital Affiliated to Hunan University, Xiangtan, China. FAU - Li, Huan AU - Li H AD - Department of Pediatrics, Xiangtan Central Hospital Affiliated to Hunan University, Xiangtan, China. FAU - Zhou, Yinfei AU - Zhou Y AD - Department of Pediatrics, Xiangtan Central Hospital Affiliated to Hunan University, Xiangtan, China. FAU - Yu, Li AU - Yu L AD - Department of Pediatrics, Xiangtan Central Hospital Affiliated to Hunan University, Xiangtan, China. LA - eng PT - Journal Article DEP - 20260817 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13526555 OTO - NOTNLM OT - abdominal pain OT - bloody stool OT - immunoglobulin A vasculitis OT - prognostic nutritional index OT - proteinuria OT - vomiting COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/09/01 13:23 MHDA- 2026/09/01 13:24 PMCR- 2026/08/17 CRDT- 2026/09/01 05:02 PHST- 2026/04/11 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/09/01 13:24 [medline] PHST- 2026/09/01 13:23 [pubmed] PHST- 2026/09/01 05:02 [entrez] PHST- 2026/08/17 00:00 [pmc-release] AID - 10.3389/fnut.2026.1853071 [doi] PST - epublish SO - Front Nutr. 2026 Aug 17;13:1853071. doi: 10.3389/fnut.2026.1853071. eCollection 2026. PMID- 42675825 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260907 IS - 1643-3750 (Electronic) IS - 1234-1010 (Print) IS - 1234-1010 (Linking) VI - 32 DP - 2026 Sep 1 TI - Development and Clinical Feasibility of a Computer-Assisted Shape Design and Bending System for Spinal Fixation Rods. PG - e952722 LID - 10.12659/MSM.952722 [doi] LID - e952722 AB - BACKGROUND Spinal pedicle screw-rod fixation is widely used, but manual rod bending is time-consuming and prone to contour inconsistencies. Although computer-assisted technologies have been explored, existing systems remain limited by cost, complexity, and insufficient precision. This study evaluated a novel computer-assisted rod design and bending system, with the goal of testing whether computer-assisted rod bending reduces bending plus installation time vs manual bending in unilateral paired cases and to evaluate safety, feasibility, and rod-screw fitting accuracy. MATERIAL AND METHODS A prospective trial enrolled 26 patients (18-75 years) undergoing spinal pedicle screw-rod fixation (>/=4 segments) for fractures or degenerative diseases. Twenty patients received unilateral computer-assisted bending (contralateral manual for comparison) and 6 received bilateral assisted bending. The primary outcome was bending plus installation time; secondary outcomes included complications and fitting accuracy. Wilcoxon signed-rank test was used (P<0.05). RESULTS No instrument-related complications were observed (n=26; median age 60.5 years). For 20 unilateral cases, computer-assisted bending (183.3+/-70.8 seconds) was significantly shorter than manual bending (236.1+/-119.1 s; mean reduction 52.75 seconds, P=0.017). Subgroup analyses indicated signals of greater time savings in more than 4 segments (93.9 seconds, P=0.039) and BMI of 25 kg/m2 or higher (95.3 seconds, P=0.005), although these were exploratory and not adjusted for multiplicity. CONCLUSIONS The computer-assisted system reduced bending plus installation time vs manual bending, with no instrument-related complications. Subgroup findings were exploratory and require further validation. FAU - Li, Xingye AU - Li X AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China. FAU - Zhang, Weijun AU - Zhang W AUID- ORCID: 0009-0000-0688-4036 AD - School of Medical Science and Engineering, Beijing Institute of Technology, Beijing, China. AD - TINAVI Medical Technologies Co., Ltd., Beijing, China. FAU - Xu, Zhongning AU - Xu Z AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China. FAU - Zhao, Yongqiang AU - Zhao Y AD - TINAVI Medical Technologies Co., Ltd., Beijing, China. FAU - An, Yan AU - An Y AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China. FAU - Li, Qingyun AU - Li Q AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China. FAU - He, Da AU - He D AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, Beijing, China. LA - eng PT - Journal Article DEP - 20260901 PL - United States TA - Med Sci Monit JT - Medical science monitor : international medical journal of experimental and clinical research JID - 9609063 SB - IM MH - Humans MH - Middle Aged MH - Female MH - Adult MH - Prospective Studies MH - Aged MH - Male MH - Adolescent MH - Pedicle Screws MH - Feasibility Studies MH - *Computer-Aided Design MH - *Fracture Fixation, Internal/methods/instrumentation MH - Young Adult MH - *Spinal Fusion/methods/instrumentation MH - *Surgery, Computer-Assisted/methods PMC - PMC13545973 COIS- Conflict of interest: None declared EDAT- 2026/09/01 05:41 MHDA- 2026/09/01 05:42 PMCR- 2026/09/01 CRDT- 2026/09/01 01:23 PHST- 2026/09/01 05:42 [medline] PHST- 2026/09/01 05:41 [pubmed] PHST- 2026/09/01 01:23 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - 952722 [pii] AID - 10.12659/MSM.952722 [doi] PST - epublish SO - Med Sci Monit. 2026 Sep 1;32:e952722. doi: 10.12659/MSM.952722. PMID- 42675564 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260903 IS - 1932-846X (Electronic) IS - 1932-8451 (Print) IS - 1932-8451 (Linking) VI - 86 IP - 4 DP - 2026 Oct TI - Does the Gut Microbiota Play a Role in Attention-Deficit/Hyperactivity Disorder in Childhood? A Pilot Study From Turkey. PG - e70057 LID - 10.1002/dneu.70057 [doi] LID - e70057 AB - The pathophysiology of attention-deficit/hyperactivity disorder (ADHD) is not fully understood, but increasing evidence suggests that gut microbiota may play a role. This study compared the gut microbiota of children with ADHD with that of a control group of healthy children, and examined their dietary and sleep habits. Ten medication-naive children aged 612 years who had recently been diagnosed with ADHD and ten healthy controls were included. ADHD diagnoses were confirmed using the Schedule for Affective Disorders and Schizophrenia for School-Age ChildrenPresent and Lifetime Version (K-SADS-PL). Sleep and eating habits were assessed using the 2nd Level Sleep Disorder Short Form, the Children's Eating Behaviour Inventory, and a form to collect sociodemographic and clinical information. The gut microbiota were analysed using 16S NGS metagenome analysis. A significant decrease in the Shannon and Simpson diversity index values was observed in the ADHD group compared to the control group. Despite the presence of a percentage difference, no statistically significant differences were observed between the groups with respect to species, genus, family, order, class or phylum. Following evaluation of the sleep and eating habit scale scores, no statistically significant difference between the groups was determined.These findings suggests that children with ADHD may alter gut microbiota diversity.However, the absence of significant taxonomic differences and the small sample size mean that these results should be interpreted with caution. Further, larger, adequately powered studies are needed to validate these findings and clarify the potential role of gut microbiota in the pathophysiology of ADHD. CI - (c) 2026 Wiley Periodicals LLC. FAU - Akyol, Cansin Kardelen AU - Akyol CK AUID- ORCID: 0000-0002-8772-3476 AD - Department of Child and Adolescent Psychiatry, Akhisar State Hospital, Manisa, Turkey. FAU - Bilac, Oznur AU - Bilac O AUID- ORCID: 0000-0001-8369-6215 AD - Department of Child and Adolescent Psychiatry, Manisa Celal Bayar University, Manisa, Turkey. FAU - Cam, Fethi Sirri AU - Cam FS AUID- ORCID: 0000-0002-0972-8896 AD - Department of Medical Genetics, Manisa Celal Bayar University, Manisa, Turkey. LA - eng GR - 2022-146/Manisa Celal Bayar University Scientific Research Projects Coordination Unit/ PT - Journal Article PL - United States TA - Dev Neurobiol JT - Developmental neurobiology JID - 101300215 SB - IM MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/microbiology/physiopathology MH - Male MH - Pilot Projects MH - *Gastrointestinal Microbiome/physiology MH - Turkey MH - Female MH - Child MH - Feeding Behavior/physiology MH - Sleep/physiology PMC - PMC13530312 OTO - NOTNLM OT - Attention-deficit/hyperactivity disorder (ADHD) OT - gut microbiota OT - hyperactivity OT - impulsivity OT - inattention OT - neurodevelopmental disorder COIS- The authors declare no conflicts of interest. EDAT- 2026/09/01 05:41 MHDA- 2026/09/01 05:42 PMCR- 2026/09/01 CRDT- 2026/09/01 00:13 PHST- 2026/07/10 00:00 [revised] PHST- 2026/02/20 00:00 [received] PHST- 2026/07/28 00:00 [accepted] PHST- 2026/09/01 05:42 [medline] PHST- 2026/09/01 05:41 [pubmed] PHST- 2026/09/01 00:13 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - DNEU70057 [pii] AID - 10.1002/dneu.70057 [doi] PST - ppublish SO - Dev Neurobiol. 2026 Oct;86(4):e70057. doi: 10.1002/dneu.70057. PMID- 42675534 OWN - NLM STAT- Publisher LR - 20260901 IS - 2542-5641 (Electronic) IS - 0366-6999 (Linking) DP - 2026 Sep 1 TI - Single-cell RNA sequencing uncovers m6A regulator-defined T-cell subpopulations and YTHDF1-HSP90AB1-MYC therapeutic axis in T-cell acute lymphoblastic leukemia. LID - 10.1097/CM9.0000000000004239 [doi] AB - BACKGROUND: N6-methyladenosine (m6A) drives T-cell acute lymphoblastic leukemia (T-ALL); however, its roles in leukemic heterogeneity and tumor microenvironment remodeling unclear. This study characterized N6-methyladenosine regulator-defined subpopulations and YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) in leukemogenesis. METHODS: Integrated single-cell and bulk RNA sequencing from 17 pediatric T-cell acute lymphoblastic leukemia patients and 3 healthy donors were analyzed. Non-negative matrix factorization based on m6A regulator expression identified distinct T-cell subpopulations. CellChat, Monocle, and single-cell regulatory network inference and clustering analyses revealed intercellular communication patterns, developmental trajectories, and transcriptional regulatory programs. Functional validations included lentiviral-mediated YTHDF1 knockdown in Jurkat and Molt4 cells for proliferation, apoptosis, and migration assays, and a non-obese diabetic severe combined immunodeficiency mouse xenograft model. Methylated RNA immunoprecipitation quantitative polymerase chain reaction, RNA immunoprecipitation quantitative polymerase chain reaction, RNA stability assays, and Western blotting characterized YTHDF1 interactions with heat shock protein 90 alpha family class B member 1 (HSP90AB1). RESULTS: Single-cell transcriptomics identified m6A-defined T-cell subpopulations in T-ALL. YTHDF1-enriched cells exhibited hypoxia and cell-cycle programs, occupied early developmental states, and communicated with macrophages. Knockdown suppressed proliferation and migration, increased apoptosis, and reduced leukemic burden in vivo. The protein bound and stabilized m6A-modified HSP90AB1 to sustain MYC proto-oncogene signaling. CONCLUSION: This study identified a YTHDF1-high m6A-associated T-cell subpopulation in T-ALL. YTHDF1 promoted leukemic progression through regulation of the HSP90AB1-MYC axis and was associated with altered macrophage-related intercellular signaling. CI - Copyright (c) 2026 The Chinese Medical Association, produced by Wolters Kluwer Health, LLC. under the CC-BY-NC-ND license. FAU - Liu, Chao AU - Liu C AD - Department of Hematology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China. FAU - Wang, Weimin AU - Wang W FAU - Wang, Fang AU - Wang F FAU - Xing, Haizhou AU - Xing H FAU - Cao, Weijie AU - Cao W FAU - Jiang, Zhongxing AU - Jiang Z LA - eng PT - Journal Article DEP - 20260901 PL - China TA - Chin Med J (Engl) JT - Chinese medical journal JID - 7513795 SB - IM OTO - NOTNLM OT - Heat shock protein 90 alpha family class B member 1 OT - N6-methyladenosine OT - Single-cell RNA sequencing OT - T-cell acute lymphoblastic leukemia EDAT- 2026/09/01 05:41 MHDA- 2026/09/01 05:41 CRDT- 2026/09/01 00:12 PHST- 2025/04/21 00:00 [received] PHST- 2026/09/01 05:41 [medline] PHST- 2026/09/01 05:41 [pubmed] PHST- 2026/09/01 00:12 [entrez] AID - 00029330-990000000-02208 [pii] AID - 10.1097/CM9.0000000000004239 [doi] PST - aheadofprint SO - Chin Med J (Engl). 2026 Sep 1. doi: 10.1097/CM9.0000000000004239. PMID- 42674753 OWN - NLM STAT- MEDLINE DCOM- 20260831 LR - 20260930 IS - 1532-656X (Electronic) IS - 0891-5245 (Linking) VI - 40 IP - 5 DP - 2026 Sep-Oct TI - Beyond "Picky Eating": Identification, Screening, and Referral for Pediatric Feeding Disorders in Primary Care. PG - 770-781 LID - S0891-5245(26)00129-X [pii] LID - 10.1016/j.pedhc.2026.05.011 [doi] AB - Pediatric feeding disorders (PFDs) affect 1 in 37 children under age 5 in the United States, representing a common yet frequently underrecognized condition in primary care. In 2019, a multidisciplinary expert panel established the first consensus definition of PFD, creating a standardized four-domain framework (medical, nutritional, feeding skill, and psychosocial) that has transformed clinical assessment and management. A recent 2025 consensus further clarified the relationship between PFD and avoidant/restrictive food intake disorder (ARFID), providing guidance on diagnostic overlap and differentiation. This continuing education article provides pediatric healthcare providers with current, evidence-based knowledge to screen, identify, and make appropriate referrals for children with PFDs. The article reviews the consensus definitions, epidemiology, validated screening tools, differential diagnosis, risk factors, assessment strategies, and referral guidelines. A case-based example illustrates the application of the four-domain framework in clinical practice. With appropriate early identification and intervention, most children with feeding difficulties can achieve improved nutritional status, oral-motor development, and positive mealtime experiences. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Taha, Asma A AU - Taha AA AD - School of Nursing, California State University, Fullerton, CA; Child Development and Rehabilitation Center (CDRC), School of Medicine, Oregon Health & Science University, Portland, OR. Electronic address: ataha@fullerton.edu. FAU - Sahl, Sarah F AU - Sahl SF AD - Child Development and Rehabilitation Center (CDRC), School of Medicine, Oregon Health & Science University, Portland, OR. FAU - Farrell, Julia R AU - Farrell JR AD - Child Development and Rehabilitation Center (CDRC), School of Medicine, Oregon Health & Science University, Portland, OR. FAU - Wright, Amber AU - Wright A AD - Child Development and Rehabilitation Center (CDRC), School of Medicine, Oregon Health & Science University, Portland, OR. FAU - Frazier, Kelsey AU - Frazier K AD - Child Development and Rehabilitation Center (CDRC), School of Medicine, Oregon Health & Science University, Portland, OR. FAU - Doan, Sylvia AU - Doan S AD - Child Development and Rehabilitation Center (CDRC), School of Medicine, Oregon Health & Science University, Portland, OR; Division of Gastroenterology, Department of Pediatrics, School of Medicine, Oregon Health & Science University, Portland, OR. LA - eng PT - Journal Article PT - Review PL - United States TA - J Pediatr Health Care JT - Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners JID - 8709735 SB - IM MH - Child, Preschool MH - Humans MH - Infant MH - Avoidant Restrictive Food Intake Disorder MH - Diagnosis, Differential MH - *Feeding and Eating Disorders/diagnosis MH - *Feeding and Eating Disorders of Childhood/diagnosis/therapy/epidemiology MH - *Mass Screening/methods MH - Practice Guidelines as Topic MH - *Primary Health Care MH - *Referral and Consultation MH - Risk Factors MH - United States/epidemiology OTO - NOTNLM OT - Avoidant/restrictive food intake disorder (ARFID) OT - Multidisciplinary assessment OT - Pediatric feeding disorder (PFD) OT - Pediatric primary care OT - Screening and early identification COIS- CONFLICTS OF INTEREST None to report. EDAT- 2026/08/31 23:43 MHDA- 2026/08/31 23:44 CRDT- 2026/08/31 20:54 PHST- 2026/02/13 00:00 [received] PHST- 2026/03/27 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/08/31 23:44 [medline] PHST- 2026/08/31 23:43 [pubmed] PHST- 2026/08/31 20:54 [entrez] AID - S0891-5245(26)00129-X [pii] AID - 10.1016/j.pedhc.2026.05.011 [doi] PST - ppublish SO - J Pediatr Health Care. 2026 Sep-Oct;40(5):770-781. doi: 10.1016/j.pedhc.2026.05.011. PMID- 42674301 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20261028 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 415 DP - 2026 Dec 15 TI - Emotion regulation and state body image during daily body-exposure situations: A pilot ecological momentary assessment study. PG - 122447 LID - S0165-0327(26)01300-5 [pii] LID - 10.1016/j.jad.2026.122447 [doi] AB - BACKGROUND: Emotion regulation has been consistently associated with eating disorder psychopathology, yet most evidence comes from retrospective and cross-sectional studies. Ecological momentary assessment (EMA) allows these processes to be examined as they unfold during daily body-exposure situations. This pilot study investigated associations among emotion regulation strategies, affect, and state body image during naturally occurring body-exposure situations and explored whether average regulatory patterns across a two-week EMA period were associated with short-term change in drive for thinness. METHOD: Thirty-four young adults completed a 14-day EMA protocol combining event-based and end-of-day assessments. Event-level measures included state body image, positive and negative affect, cognitive reappraisal, expressive suppression, and rumination. Drive for thinness was assessed at baseline and post-monitoring. Pearson correlations examined associations among participant-level averages, a linear mixed-effects model tested event-level associations, and multiple regression examined whether average emotion regulation variables were associated with post-monitoring drive for thinness after controlling for baseline scores. RESULTS: Participants completed 305 EMA entries, corresponding to 64.08% adherence. More positive average body image was associated with higher positive affect and lower negative affect, expressive suppression, and rumination. At the event level, greater expressive suppression and rumination were associated with poorer state body image, whereas cognitive reappraisal was not. Baseline drive for thinness was significantly associated with post-monitoring scores. None of the EMA-derived emotion regulation variables was significantly associated with post-monitoring drive for thinness after controlling for baseline levels. DISCUSSION: These preliminary findings suggest that expressive suppression and rumination may co-occur with poorer state body image during everyday body-salient situations. Larger EMA studies using parallel and validated measures of emotion regulation are needed to clarify these associations and their temporal relevance. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Rojas-Rincon, Juliana AU - Rojas-Rincon J AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain. FAU - Gamiz-Sanfeliu, Maria AU - Gamiz-Sanfeliu M AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain. FAU - Ampatzoglou, Aikaterini AU - Ampatzoglou A AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain. FAU - Carballo-Marquez, Anna AU - Carballo-Marquez A AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain. FAU - Garolera, Maite AU - Garolera M AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain; Brain, Cognition, and Behavior Research Group, Consorci Sanitari de Terrassa-Hospital Universitari, 08227, Terrassa, Spain. FAU - Fernandez-Capo, Maria AU - Fernandez-Capo M AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain. FAU - Porras-Garcia, Bruno AU - Porras-Garcia B AD - BrainXR Lab, Department of Psychology, Universitat Internacional de Catalunya, 08195, Sant Cugat del Valles, Spain; Brain, Cognition, and Behavior Research Group, Consorci Sanitari de Terrassa-Hospital Universitari, 08227, Terrassa, Spain. Electronic address: bporras@uic.es. LA - eng PT - Journal Article DEP - 20260901 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 SB - IM EIN - J Affect Disord. 2026 Oct 28:122659. doi: 10.1016/j.jad.2026.122659. PMID: 42951731 MH - Humans MH - *Emotional Regulation MH - *Ecological Momentary Assessment MH - Pilot Projects MH - *Body Image/psychology MH - Female MH - Male MH - Young Adult MH - Rumination, Cognitive MH - Affect MH - Adult MH - Thinness/psychology MH - Adolescent OTO - NOTNLM OT - Affect OT - Body image OT - Eating disorders OT - Ecological momentary assessment OT - Emotion regulation OT - Prevention OT - Rumination OT - Suppression COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/31 23:43 MHDA- 2026/09/25 23:47 CRDT- 2026/08/31 19:14 PHST- 2026/05/13 00:00 [received] PHST- 2026/07/30 00:00 [revised] PHST- 2026/08/29 00:00 [accepted] PHST- 2026/09/25 23:47 [medline] PHST- 2026/08/31 23:43 [pubmed] PHST- 2026/08/31 19:14 [entrez] AID - S0165-0327(26)01300-5 [pii] AID - 10.1016/j.jad.2026.122447 [doi] PST - ppublish SO - J Affect Disord. 2026 Dec 15;415:122447. doi: 10.1016/j.jad.2026.122447. Epub 2026 Sep 1. PMID- 42674154 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261009 IS - 1873-6963 (Electronic) IS - 0965-2299 (Linking) VI - 102 DP - 2026 Nov TI - Perceptual-motor vision training approaches for the prevention of computer vision syndrome in college students: A narrative review. PG - 103427 LID - S0965-2299(26)00110-X [pii] LID - 10.1016/j.ctim.2026.103427 [doi] AB - Computer Vision Syndrome (CVS), also referred to as Digital Eye Strain (DES), is a common condition among college students and other digital-device users and is associated with prolonged near work, reduced blinking, and sustained visual attention. Conventional preventive strategies, including ergonomic optimization and scheduled visual breaks, primarily address environmental risk factors but do not directly target the perceptual-motor mechanisms underlying visual fatigue and oculomotor inefficiency. Perceptual-Motor Vision Training (PMVT) is an emerging complementary, non-pharmacological approach designed to enhance accommodation, vergence, oculomotor control, visuomotor integration, and visual information processing through structured visuomotor exercises. This narrative review synthesizes evidence from vision science, motor learning, and applied performance research to evaluate the potential role of PMVT in preventing or mitigating CVS-related visual fatigue in college students. Available evidence suggests that PMVT may improve selected visual and visuomotor functions. However, because most supporting studies involve athletic, pediatric, clinical, or non-CVS populations, its effectiveness for preventing CVS in healthy college students remains unproven. PMVT should therefore be considered an investigational complementary approach alongside ergonomic and behavioral strategies. Despite promising theoretical and preliminary empirical support, current evidence is limited by heterogeneous outcome measures, a scarcity of randomized controlled trials in non-athletic populations, and insufficient specification of training dosage and protocols. Future interdisciplinary research is required to establish standardized perceptual-motor metrics, determine dose-response relationships, and evaluate the clinical effectiveness and feasibility of PMVT as a low-cost complementary intervention for reducing digital task-related visual fatigue and improving visual performance in student populations. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Zhong, Huihui AU - Zhong H AD - Suzhou Polytechnic University, Suzhou 215002, China. FAU - Gao, Dongxu AU - Gao D AD - Division of Sports Science and Physical Education, Tsinghua University, Beijing 100084, China. Electronic address: gdx@tsinghua.edu.cn. FAU - Xiao, Youlin AU - Xiao Y AD - Sports College, Dalian University, Dalian 116622, China. FAU - Wang, Yusen AU - Wang Y AD - Southwest University of Political Science and Law, Yubei 401120, China. FAU - Dong, Xiushen AU - Dong X AD - Normal University, Changsha City, Hunan Province 410081, China. FAU - Zhao, Zihao AU - Zhao Z AD - School of Medicine, Shaanxi University of Chinese Medicine, Xianyang 712000, China. LA - eng PT - Journal Article PT - Review DEP - 20260831 PL - Scotland TA - Complement Ther Med JT - Complementary therapies in medicine JID - 9308777 SB - IM MH - Humans MH - Students MH - *Asthenopia/prevention & control MH - Universities MH - Digital Media OTO - NOTNLM OT - Computer vision syndrome OT - Perceptual-Motor Vision Training OT - Perceptual-motor skills OT - Visual performance OT - Visuomotor learning COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/31 23:43 MHDA- 2026/10/09 23:31 CRDT- 2026/08/31 19:11 PHST- 2026/01/23 00:00 [received] PHST- 2026/08/05 00:00 [revised] PHST- 2026/08/29 00:00 [accepted] PHST- 2026/10/09 23:31 [medline] PHST- 2026/08/31 23:43 [pubmed] PHST- 2026/08/31 19:11 [entrez] AID - S0965-2299(26)00110-X [pii] AID - 10.1016/j.ctim.2026.103427 [doi] PST - ppublish SO - Complement Ther Med. 2026 Nov;102:103427. doi: 10.1016/j.ctim.2026.103427. Epub 2026 Aug 31. PMID- 42673582 OWN - NLM STAT- MEDLINE DCOM- 20260831 LR - 20260917 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Aug 31 TI - Remote Assessment of Physical Function and Physical Activity in Adults With Autism Spectrum Disorder: Protocol for Feasibility, Validity, and Reliability Study. PG - e86020 LID - 10.2196/86020 [doi] LID - e86020 AB - BACKGROUND: Adults with autism spectrum disorder (ASD) are at increased risk for chronic health conditions and reduced quality of life (QoL), often linked to lower physical activity (PA), motor impairments, and barriers to health care access. Although communication and social differences in ASD are well documented, motor impairments such as deficits in coordination, balance, and gait remain understudied in adulthood despite their relevance to fall risk and PA participation. Telehealth and wearable technologies may improve access to physical therapy assessment and remote monitoring of physical function in this underserved population. OBJECTIVE: This pilot study aims to evaluate the feasibility, construct validity, and rating reliability of remotely administered physical function and balance assessments in adults with ASD and to examine racial and ethnic disparities and associations among physical function, PA, fall risk, and QoL. METHODS: This pilot study uses a 2-phase, cross-sectional, noninterventional design with remote data collection in legally independent adults aged 18-59 years with ASD who were recruited through the Simons Powering Autism Research and Knowledge (SPARK) registry. Participants complete self-report questionnaires; 2 weeks of wearable step monitoring using a Fitbit Inspire 3 (Google LLC) device; and, for a randomized subset of 25 participants, 1 remote, telehealth-based physical function assessment session. Remote performance-based measures include the Five Times Sit-to-Stand, 30-second Sit-to-Stand, standing balance under eyes open and eyes closed conditions, and single-leg stance under eyes open and eyes closed conditions. Construct validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) physical function measures will be examined using hypothesis testing with related indicators of health and functioning, including steps per day, lower-extremity functional outcome surveys, fall risk screening surveys, and comorbidity burden. Interrater and intrarater reliability of remote performance scoring will be evaluated from video-recorded sessions scored by 6 raters using intraclass correlation coefficients. Secondary analyses will examine racial and ethnic disparities in physical function, PA, and QoL, as well as associations among these variables and moderation by race and ethnicity. RESULTS: Study funding was available from August 2024 to May 2025. Recruitment occurred from December 2024 to March 2025, and final data collection was completed in May 2025. By May 2025, 155 adults with ASD had been recruited, of whom 65.2% were female and 77% identified as Black or Hispanic. Data analysis is projected to be completed in July 2026, and submission of the primary results manuscript is anticipated in August 2026. CONCLUSIONS: This protocol describes a pilot study designed to evaluate the feasibility, construct validity, and equity relevance of remotely administered physical function assessments in adults with ASD. If supported, the findings may provide preliminary evidence for more accessible telehealth-based assessment approaches and inform larger studies on physical functioning, PA, and QoL in this population. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/86020. CI - (c)Annabel Nunez-Gaunaurd, Melissa M Tovin, Melissa Hale, Tan Li, Anjana Bhat. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 31.08.2026. FAU - Nunez-Gaunaurd, Annabel AU - Nunez-Gaunaurd A AUID- ORCID: 0000-0002-2977-7994 AD - Department of Physical Therapy, Nicole Wertheim College of Nursing & Health Sciences, Florida International University, Miami, FL, United States. FAU - Tovin, Melissa M AU - Tovin MM AUID- ORCID: 0000-0003-1355-3117 AD - Department of Physical Therapy, Miller School of Medicine, University of Miami, Miami, FL, United States. FAU - Hale, Melissa AU - Hale M AUID- ORCID: 0000-0001-5963-4794 AD - Division Director, Child and Family Services, College of Arts and Sciences, University of Miami, Miami, FL, United States. FAU - Li, Tan AU - Li T AUID- ORCID: 0000-0001-6871-7719 AD - Department of Biostatistics, Stempel College of Public Health, Florida International University, Miami, FL, United States. FAU - Bhat, Anjana AU - Bhat A AUID- ORCID: 0000-0002-0771-0967 AD - Department of Physical Therapy, College of Health Sciences, University of Delaware, Newark, DE, United States. LA - eng GR - U54 MD012393/MD/NIMHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260831 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Adult MH - Pilot Projects MH - Female MH - Feasibility Studies MH - Male MH - Reproducibility of Results MH - Middle Aged MH - *Exercise/physiology MH - Cross-Sectional Studies MH - Adolescent MH - *Autism Spectrum Disorder/physiopathology/psychology MH - Young Adult MH - Quality of Life MH - Surveys and Questionnaires MH - Telemedicine PMC - PMC13575549 OTO - NOTNLM OT - adult autism OT - autism in adulthood OT - autism spectrum disorder OT - co-participation OT - cross-sectional design OT - digital health OT - family support OT - health disparities OT - minority health OT - motor impairments OT - patient-reported outcomes OT - physical activity OT - physical function OT - protocol study OT - rehabilitation OT - remote assessment OT - telehealth OT - wearable devices COIS- Conflicts of Interest: None declared. EDAT- 2026/08/31 19:42 MHDA- 2026/08/31 23:43 PMCR- 2026/08/31 CRDT- 2026/08/31 16:53 PHST- 2025/10/16 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/08/31 23:43 [medline] PHST- 2026/08/31 19:42 [pubmed] PHST- 2026/08/31 16:53 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - v15i1e86020 [pii] AID - 10.2196/86020 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Aug 31;15:e86020. doi: 10.2196/86020. PMID- 42670969 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260918 LR - 20260920 IS - 2149-2042 (Print) IS - 2149-4606 (Electronic) IS - 2149-4606 (Linking) VI - 41 IP - 3 DP - 2026 Sep 18 TI - Evaluation of Early Diagnostic Methods for Subclinical Cardiovascular Changes in Childhood Obesity. PG - 296-308 LID - 10.4274/MMJ.galenos.2026.59783 [doi] AB - Childhood obesity is associated with early cardiometabolic abnormalities and subclinical vascular and cardiac changes. This narrative review summarizes the mechanisms underlying these changes and evaluates non-invasive methods used for early detection. PubMed/MEDLINE and Scopus were searched for pediatric studies, systematic reviews, and guidelines, and the principal evidence sources were appraised using design-appropriate tools. Blood pressure measurement, anthropometry, and age-and risk-based laboratory testing remain the basis of routine assessment. Carotid intima-media thickness, pulse wave velocity, endothelial function tests, heart rate variability, advanced echocardiographic measures, and epicardial adipose tissue assessment are promising; however, methodological heterogeneity and limited pediatric reference values restrict most of them to selected clinical or research settings. Standardized longitudinal studies are required to validate thresholds and determine whether test-guided strategies improve outcomes. CI - Copyright(c) 2026 The Author(s). Published by Galenos Publishing House on behalf of Istanbul Medeniyet University Faculty of Medicine. FAU - Badem, Meryem AU - Badem M AUID- ORCID: 0000-0002-6930-2424 AD - Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Pediatric Endocrinology, Istanbul, Turkiye. FAU - Hepokur, Merve Nur AU - Hepokur MN AUID- ORCID: 0000-0002-5470-1254 AD - Marmara University Pendik Training and Research Hospital, Department of Pediatric Cardiology, Istanbul, Turkiye. FAU - Karagozlu, Selen AU - Karagozlu S AUID- ORCID: 0000-0002-9542-1937 AD - Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Pediatric Endocrinology, Istanbul, Turkiye. FAU - Emeksiz, Hamdi Cihan AU - Emeksiz HC AUID- ORCID: 0000-0002-4815-1591 AD - Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Pediatric Endocrinology, Istanbul, Turkiye. LA - eng PT - Journal Article DEP - 20260831 PL - Turkey TA - Medeni Med J JT - Medeniyet medical journal JID - 101676811 PMC - PMC13586907 OTO - NOTNLM OT - Pediatric obesity OT - atherosclerosis OT - cardiovascular diagnostic techniques OT - cardiovascular diseases COIS- The authors declare that they have no conflict of interest related to this study. EDAT- 2026/08/31 19:42 MHDA- 2026/08/31 19:43 PMCR- 2026/09/18 CRDT- 2026/08/31 07:12 PHST- 2026/08/31 19:43 [medline] PHST- 2026/08/31 19:42 [pubmed] PHST- 2026/08/31 07:12 [entrez] PHST- 2026/09/18 00:00 [pmc-release] AID - 10.4274/MMJ.galenos.2026.59783 [doi] PST - ppublish SO - Medeni Med J. 2026 Sep 18;41(3):296-308. doi: 10.4274/MMJ.galenos.2026.59783. Epub 2026 Aug 31. PMID- 42670657 OWN - NLM STAT- MEDLINE DCOM- 20260831 LR - 20260903 IS - 1745-5065 (Electronic) IS - 1745-5057 (Print) IS - 1745-5057 (Linking) VI - 22 DP - 2026 Jan-Dec TI - To what extent does the adapted Women's empowerment in nutrition index demonstrate psychometric validity and determine the nutritional empowerment among pregnant women in southern Ethiopia? PG - 17455057261484831 LID - 10.1177/17455057261484831 [doi] LID - 17455057261484831 AB - BackgroundWomen's empowerment plays a crucial role in the wellbeing of families by affecting nutrition and health. Women's Empowerment in Nutrition Index (WENI) was recently developed in rural South Asia, but requires validation in new contexts.ObjectiveThe study aimed to evaluate the psychometric validation of the WENI, the level of nutritional empowerment and factors associated with nutritional empowerment among pregnant women in Southern Ethiopia.DesignA facility-based cross-sectional study design was employed.MethodsThe study was conducted among 392 pregnant women from March 10 to May 30, 2025. The structural validity of the WENI was assessed using Exploratory and Confirmatory Factor Analysis (EFA/CFA) to identify latent constructs of empowerment. Kaiser-Meyer-Olkin (>/= 0.60) and significant results in Bartlett's Test (p < 0.05) were used for confirming sampling adequacy. Independent factors were identified using a hierarchical negative binomial multiple regression with adjusted incidence rate ratios (aIRRs) calculated, considering statistical significance at p < 0.05.ResultsFactor analysis revealed a six-factor structure with an internal consistency (Cronbach's alpha = 0.86), and convergent and discriminant validities (AVE=0.50, CR=0.70). The model demonstrated strong fit indices (CFI= 0.94; RMSEA<0.06). A significant relationship was found between WENI scores and maternal and child nutrition outcomes (p<0.001), with 51.5% of women being nutritionally empowered. Empowerment was higher in women free from intimate partner violence (aIRR = 1.12), those receiving nutritional counseling (aIRR = 1.33). Conversely, empowerment rates were lower in women with no formal education (aIRR = 0.76) and those in the lowest wealth quintile (aIRR = 0.82).ConclusionThis study confirmed that nutritional empowerment, measured via a 21-item tool, improves maternal health and food security. However, social norms and a "knowledge-agency gap" persist. Interventions must shift from basic education to actively promoting women's control over resources, gender equality, and stronger community-based support systems to be truly effective. FAU - Fikrie, Anteneh AU - Fikrie A AUID- ORCID: 0000-0002-9809-3326 AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 FAU - Wodessa, Gelgelo AU - Wodessa G AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 FAU - Gelchu, Miesa AU - Gelchu M AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 FAU - Jofa, Bekam Yambo AU - Jofa BY AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 FAU - Hailu, Dejene AU - Hailu D AD - School of Public Health, Hawassa University College of Medicine and Health Sciences, Awassa, Ethiopia. RINGGOLD: 293657 FAU - Abera, Mubarek AU - Abera M AD - Department of Psychiatry, Faculty of Medical Science, Jimma University, Jimma, Oromia, Ethiopia. RINGGOLD: 107839 FAU - Spigt, Mark AU - Spigt M AD - Department of Family Medicine, Universiteit Maastricht Care and Public Health Research Institute, Maastricht, Netherlands. LA - eng PT - Journal Article DEP - 20260831 PL - United States TA - Womens Health (Lond) JT - Women's health (London, England) JID - 101271249 SB - IM MH - Humans MH - Female MH - Ethiopia MH - *Psychometrics MH - Cross-Sectional Studies MH - *Empowerment MH - Adult MH - Pregnancy MH - *Pregnant People/psychology MH - Reproducibility of Results MH - *Nutritional Status MH - Surveys and Questionnaires/standards MH - Young Adult MH - *Power, Psychological MH - Rural Population PMC - PMC13530473 OAB - This study assessed how to measure nutritional empowerment, woman ability to make decisions that impact the health and nutrition of herself and her family's among 392 pregnant women in Southern Ethiopia. By using a 21-item tool called the Women's Empowerment in Nutrition Index (WENI), researchers confirmed that the survey is an accurate and reliable way to measure these capabilities in the region. The findings showed that about 51.5% of the women surveyed were nutritionally empowered, a status that was directly linked to better overall health outcomes for both mothers and children. The study identified clear factors that influence whether a woman can exercise this control. Women were significantly more likely to be empowered if they received nutritional counselling or lived in households free from intimate partner violence. Conversely, empowerment was lower among women who had no formal education or lived in the lowest income households. Ultimately, the researchers concluded that while nutritional knowledge is important, it is not enough on its own. To bridge the gap between knowing about health and having the agency to act on it, future interventions must shift focus toward promoting gender equality, securing women control over household resources, and strengthening community-based support systems. OABL- eng OTO - NOTNLM OT - factor analysis OT - pregnant women OT - psychometric validation OT - women's empowerment COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/08/31 19:42 MHDA- 2026/08/31 19:43 PMCR- 2026/08/31 CRDT- 2026/08/31 04:33 PHST- 2026/08/31 19:43 [medline] PHST- 2026/08/31 19:42 [pubmed] PHST- 2026/08/31 04:33 [entrez] PHST- 2026/08/31 00:00 [pmc-release] AID - 10.1177_17455057261484831 [pii] AID - 10.1177/17455057261484831 [doi] PST - ppublish SO - Womens Health (Lond). 2026 Jan-Dec;22:17455057261484831. doi: 10.1177/17455057261484831. Epub 2026 Aug 31. PMID- 42670279 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261010 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 83 IP - 4 DP - 2026 Oct TI - Mid-upper arm circumference, steatosis indices, and elastography for screening liver steatosis in children with overweight/obesity: A prospective cross-sectional study. PG - 616-623 LID - 10.1002/jpn3.70554 [doi] AB - OBJECTIVES: Metabolic dysfunction-associated steatotic liver disease (MASLD) is common in children, and practical screening approaches are needed in populations with overweight/obesity. We aimed to evaluate mid-upper arm circumference (MUAC) as a simple marker for ultrasonography (US)-detected liver steatosis (LS) in children with overweight/obesity, to examine the performance of other non-invasive measures, and to assess MUAC-based composite cut-offs. METHODS: In this study, 194 children with overweight/obesity aged 5-17 years were evaluated at a pediatric gastroenterology clinic. US-detected LS was defined as US grade >/=1. Liver stiffness was measured by two-dimensional shear-wave elastography (2D-SWE). Fasting biochemistry was obtained, and alanine aminotransferase (ALT)/aspartate aminotransferase (AST) ratio, Hepatic Steatosis Index, and Framingham Steatosis Index were calculated. Associations between US-detected LS and anthropometric, biochemical, and liver stiffness measures were assessed using Spearman correlation, logistic regression, and receiver operating characteristic analyses; composite models used an odds ratio-rule approach. RESULTS: US-detected LS was present in 55.2%. MUAC >/= 30.0 cm yielded an area under the curve (AUC) of 0.738 for identifying US-detected LS. A composite rule of body mass index (BMI) z score >/=1.70 or MUAC >/= 30.0 cm achieved 97.2% sensitivity and 54.0% specificity for identifying US-detected LS, with an AUC of 0.813, negative predictive value 94.0%, and positive predictive value 72.2%. Adding liver stiffness >/=5.68 kPa increased discrimination for identifying US-detected LS, with an AUC of 0.881. CONCLUSION: MUAC is a low-cost adjunct for screening US-detected LS in children with overweight/obesity. Simple composite cut-offs integrating MUAC with BMI showed high sensitivity in this cohort and may support initial risk stratification before ultrasonographic evaluation; adding liver stiffness yielded the highest discriminative performance. CI - (c) 2026 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Teke, Selcuk AU - Teke S AUID- ORCID: 0000-0002-1885-6611 AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Cavis, Tugba AU - Cavis T AUID- ORCID: 0000-0001-8878-9568 AD - Department of Radiology, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Ergen, Yasin Maruf AU - Ergen YM AUID- ORCID: 0000-0002-3689-6852 AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Akcay, Birce Izgi AU - Akcay BI AUID- ORCID: 0000-0002-1325-0899 AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Basaran, Edibe Gozde AU - Basaran EG AUID- ORCID: 0000-0003-3165-3234 AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Balamtekin, Necati AU - Balamtekin N AUID- ORCID: 0000-0001-8665-5611 AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. LA - eng GR - None/ PT - Journal Article DEP - 20260831 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM MH - Humans MH - Child MH - *Elasticity Imaging Techniques/methods MH - Male MH - Female MH - Adolescent MH - Prospective Studies MH - Cross-Sectional Studies MH - Child, Preschool MH - *Fatty Liver/diagnosis/etiology/diagnostic imaging MH - *Arm/anatomy & histology MH - *Pediatric Obesity/complications MH - *Overweight/complications MH - Liver/diagnostic imaging/pathology MH - Body Mass Index MH - ROC Curve MH - Mass Screening/methods MH - Sensitivity and Specificity MH - Anthropometry PMC - PMC13646030 OTO - NOTNLM OT - Framingham Steatosis Index OT - Hepatic Steatosis Index OT - body mass index OT - elasticity imaging techniques OT - fatty liver COIS- The authors declare no conflict of interest. EDAT- 2026/08/31 19:42 MHDA- 2026/10/08 05:31 PMCR- 2026/10/08 CRDT- 2026/08/31 03:23 PHST- 2026/07/22 00:00 [revised] PHST- 2026/03/17 00:00 [received] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/10/08 05:31 [medline] PHST- 2026/08/31 19:42 [pubmed] PHST- 2026/08/31 03:23 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - JPN370554 [pii] AID - 10.1002/jpn3.70554 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Oct;83(4):616-623. doi: 10.1002/jpn3.70554. Epub 2026 Aug 31. PMID- 42670172 OWN - NLM STAT- MEDLINE DCOM- 20260831 LR - 20260902 IS - 2057-4347 (Electronic) IS - 2057-4347 (Linking) VI - 12 IP - 5 DP - 2026 Oct TI - Machine Learning Prediction of Anterior Open-Bite Development After Stabilization Splint Treatment in Temporomandibular Disorder. PG - e70447 LID - 10.1002/cre2.70447 [doi] LID - e70447 AB - OBJECTIVES: To develop interpretable machine learning (ML) models for risk stratification of clinically meaningful anterior overbite decrease after stabilization splint therapy in temporomandibular disorder (TMD) patients, and to compare ML performance with conventional logistic regression. MATERIALS AND METHODS: This retrospective cohort included 87 TMD patients treated with stabilization splints, physical therapy, and pharmacologic therapy. Thirty-five pre-treatment cephalometric and demographic features were used. The primary outcome was overbite difference (OD = post-treatment minus pre-treatment overbite). For classification, patients were labeled as Decrease (OD < -0.5 mm; n = 37) versus Non-Decrease (OD >/= -0.5 mm; n = 50), combining No Change and Increase due to severe imbalance in the Increase subgroup. Six classifiers (logistic regression, random forest, extreme gradient boosting (XGBoost), Light Gradient Boosting Machine, support vector machine, k-nearest neighbors) were evaluated using stratified fivefold cross-validation and leave-one-out cross-validation. Class imbalance was handled using class-weighting and the Synthetic Minority Over-sampling Technique (SMOTE) applied within the cross-validation loop. For regression, nine algorithms were tested to predict continuous OD. Model explainability was assessed using SHapley Additive exPlanations (SHAP). RESULTS: In fivefold cross-validation, XGBoost achieved the best discrimination (AUC = 0.734), outperforming logistic regression (AUC = 0.611). With SMOTE, the random forest achieved a comparable AUC (0.735) with improved sensitivity. Across regression models, cross-validated R(2) values were near-zero or negative, indicating limited ability to predict the exact magnitude of overbite change from baseline variables alone. SHAP ranked pre-treatment overbite, ramus height, upper occlusal plane to SN angle, sella-to-condylion distance, and condylar positional indices among the most influential predictors for classification. CONCLUSION: Interpretable ML enables improved risk stratification for clinically meaningful anterior overbite decrease after stabilization splint therapy in TMD patients, whereas predicting the exact magnitude of overbite change remains limited using pre-treatment cephalometrics alone. These models may support individualized counseling and closer monitoring for patients at higher risk of open-bite development during splint therapy. CI - (c) 2026 The Author(s). Clinical and Experimental Dental Research published by John Wiley & Sons Ltd. FAU - Hwang, Jae Joon AU - Hwang JJ AUID- ORCID: 0000-0003-0379-8460 AD - Department of Oral and Maxillofacial Radiology, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan, Republic of Korea. AD - Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Republic of Korea. FAU - Jeon, Hye-Mi AU - Jeon HM AUID- ORCID: 0000-0003-0007-5662 AD - Department of Oral Medicine, Pusan National University Hospital, Busan, Republic of Korea. AD - Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea. FAU - Ju, Hye-Min AU - Ju HM AUID- ORCID: 0000-0002-9252-6717 AD - Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Republic of Korea. AD - Department of Oral Medicine, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan, Republic of Korea. FAU - Jeong, Sung-Hee AU - Jeong SH AUID- ORCID: 0000-0002-6296-4775 AD - Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Republic of Korea. AD - Department of Oral Medicine, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan, Republic of Korea. FAU - Ahn, Yong-Woo AU - Ahn YW AUID- ORCID: 0000-0002-2197-0394 AD - Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Republic of Korea. AD - Department of Oral Medicine, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan, Republic of Korea. FAU - Ok, Soo-Min AU - Ok SM AUID- ORCID: 0000-0003-1776-371X AD - Dental Research Institute, Pusan National University Dental Hospital, Yangsan, Republic of Korea. AD - Department of Oral Medicine, Dental and Life Science Institute, School of Dentistry, Pusan National University, Yangsan, Republic of Korea. LA - eng GR - RS-2025-20082969/National Research Foundation of Korea/ GR - RS-2023-00217689/National Research Foundation of Korea/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Clin Exp Dent Res JT - Clinical and experimental dental research JID - 101692332 SB - IM MH - Humans MH - Retrospective Studies MH - *Temporomandibular Joint Disorders/therapy/complications MH - *Machine Learning MH - Female MH - Predictive Learning Models MH - Boosting Machine Learning Algorithms MH - Random Forest MH - *Open Bite/etiology/diagnosis MH - *Occlusal Splints MH - Classification Algorithms MH - Prediction Algorithms MH - Logistic Models MH - Cephalometry MH - Adult MH - Young Adult MH - Adolescent MH - Risk Assessment/methods PMC - PMC13527398 OTO - NOTNLM OT - machine learning OT - occlusal splint OT - open-bite OT - temporomandibular disorders COIS- The authors declare no conflicts of interest. EDAT- 2026/08/31 19:42 MHDA- 2026/08/31 19:43 PMCR- 2026/08/30 CRDT- 2026/08/31 02:02 PHST- 2026/08/11 00:00 [revised] PHST- 2026/02/28 00:00 [received] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/08/31 19:43 [medline] PHST- 2026/08/31 19:42 [pubmed] PHST- 2026/08/31 02:02 [entrez] PHST- 2026/08/30 00:00 [pmc-release] AID - CRE270447 [pii] AID - 10.1002/cre2.70447 [doi] PST - ppublish SO - Clin Exp Dent Res. 2026 Oct;12(5):e70447. doi: 10.1002/cre2.70447. PMID- 42669329 OWN - NLM STAT- Publisher LR - 20261001 IS - 2589-5559 (Electronic) IS - 2589-5559 (Linking) DP - 2026 Aug 30 TI - Clinical and Metabolomic Panel for Noninvasive Screening of Biopsy-Confirmed MASH in Children and Adolescents. PG - 102016 LID - S2589-5559(26)00287-9 [pii] LID - 10.1016/j.jhepr.2026.102016 [doi] AB - BACKGROUND & AIMS: Noninvasive tests to identify pediatric metabolic dysfunction-associated steatohepatitis (MASH) remain a critical need. We aimed to develop and validate a screening panel that identifies biopsy-confirmed MASH in children and adolescents using clinical and metabolomics data. METHODS: Fasting serum from youth in NASH CRN studies and healthy participants underwent untargeted metabolomics by liquid chromatography-mass spectrometry (LC-MS). Clinical data included anthropometrics, lipids, liver enzymes, and markers of insulin resistance. MASH was determined by biopsy in NASH CRN participants and hepatic steatosis by MRI-PDFF in healthy participants. Clinical features were selected by Kolmogorov-Smirnov testing (p < 0.05), and metabolomics data were reduced to 52 features with non-zero LASSO coefficients. Feature importance was ranked using CatBoost. The final model included eight clinical features and the top 10 annotated metabolites. Data were split into training and test sets, with longitudinal validation in a sub-cohort with 96-week follow-up biopsies. RESULTS: The cohort included 586 children (ages 5-18, 70% male, mean BMI z-score of 2.35 +/- 0.84, 72% Hispanic). Of these, 390 had MASH (21% Zone 3, 41% Zone 1, 38% definite MASH), and 196 were non-MASH. The model incorporated ALT, AST, GGT, platelets, HOMA-IR, BMI z-score, TG:HDL ratio, and alkaline phosphatase. Key metabolic features included amino acid derivatives (e.g., glutamic acid, argininosuccinic acid), indole, diacetylspermine, and lipid metabolites. The model achieved an AUROC of 0.88 (92% sensitivity, 71% specificity) in the test set and 0.81 (69% sensitivity, 86% specificity) in the longitudinal cohort. CONCLUSIONS: This 18-variable panel of eight clinical measures and 10 metabolites showed strong performance for noninvasive screening of biopsy-confirmed MASH in children and potential utility for longitudinal monitoring. IMPACT AND IMPLICATIONS: Currently, there are no clinically approved non-invasive biomarkers for diagnosing or monitoring pediatric MASH, despite its growing prevalence and long-term health risks. This study developed and validated a machine-learning-based panel that combines clinical and high-resolution metabolomics data, demonstrating strong performance for classifying MASH and monitoring disease status in a longitudinal cohort. These findings are particularly relevant for improving the care of children with MASH and could inform both clinical practice and research. With further validation, this approach could reduce reliance on liver biopsy, enable earlier detection, and support clinical decision-making for physicians and researchers. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Huneault, Helaina E AU - Huneault HE AD - Department of Pediatrics and Human Development, Michigan State University, College of Human Medicine, Grand Rapids, MI, USA; Department of Pediatrics, Division of Gastroenterology, Hepatology, & Nutrition, Emory University, Atlanta, GA, USA. Electronic address: hhuneau@emory.edu. FAU - Sudhakar, Shrramana Ganesh AU - Sudhakar SG AD - School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, USA; Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA. FAU - Gent, Alasdair E AU - Gent AE AD - Department of Surgery, Duke University School of Medicine, Durham, NC, USA; Department of Anesthesiology, Duke University, Durham, NC, USA. FAU - Jarrell, Zachery R AU - Jarrell ZR AD - Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, Atlanta, GA, USA. FAU - Smith, Matthew Ryan AU - Smith MR AD - Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Emory University, Atlanta, GA, USA; VA Healthcare System of Atlanta, Decatur, GA, USA. FAU - Sanchez-Torres, Cristian AU - Sanchez-Torres C AD - Department of Pediatrics, Division of Gastroenterology, Hepatology, & Nutrition, Emory University, Atlanta, GA, USA. FAU - Jain, Ajay K AU - Jain AK AD - Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, USA. FAU - Yates, Katherine P AU - Yates KP AD - Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Neuschwander-Tetri, Brent A AU - Neuschwander-Tetri BA AD - Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, USA. FAU - Schwimmer, Jeffrey B AU - Schwimmer JB AD - Department of Gastroenterology, Rady Children's Hospital San Diego, San Diego, CA, USA; Department of Pediatrics, School of Medicine, University of California, San Diego, CA, USA. FAU - Xanthakos, Stavra A AU - Xanthakos SA AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. FAU - Molleston, Jean P AU - Molleston JP AD - Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Riley Children's Health, Indianapolis, IN, USA. FAU - Behling, Cynthia A AU - Behling CA AD - Sharp Memorial Hospital, San Diego, California, USA. FAU - Fishbein, Mark H AU - Fishbein MH AD - Department of Pediatrics, Feinberg School of Medicine at Northwestern University, Chicago, Illinois, USA. FAU - Kamaleswaran, Rishikesan AU - Kamaleswaran R AD - Department of Biomedical Informatics, Emory University School of Medicine, Atlanta, GA, USA; Department of Biomedical Engineering, Duke University, Durham, NC, USA; Department of Surgery, Duke University School of Medicine, Durham, NC, USA; Department of Anesthesiology, Duke University, Durham, NC, USA; Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA. FAU - Vos, Miriam B AU - Vos MB AD - Department of Pediatrics and Human Development, Michigan State University, College of Human Medicine, Grand Rapids, MI, USA; Department of Pediatrics, Division of Gastroenterology, Hepatology, & Nutrition, Emory University, Atlanta, GA, USA; Children's Healthcare of Atlanta, Atlanta, GA, USA; Helen DeVos Children's Hospital, Corewell Health, Grand Rapids, MI, USA. LA - eng PT - Journal Article DEP - 20260830 PL - Netherlands TA - JHEP Rep JT - JHEP reports : innovation in hepatology JID - 101761237 SB - IM OTO - NOTNLM OT - MASLD OT - biomarker discovery OT - gradient boosting OT - histology COIS- Conflicts of interest MBV serves as a consultant to Boehringer Ingelheim, Novo Nordisk, Eli Lilly, Intercept, Takeda, and Alberio. She has stock or stock options in Thiogenesis and Tern Pharmaceuticals. Her institution has received research grants (or in-kind research services) from Target Real World Evidence, Quest, Labcorp, and Sonic Incytes Medical Corp. JPM has research grant funding from Gilead, Abbvie, Albireo, and Mirum. BANT: Advisor or consultant: Abbvie, Akero, Aldeyra, Aligos, Arrowhead, Corcept, Galectin, GSK, Hepion, HistoIndex, Madrigal, Merck, Mirum, Pfizer, Sagimet, Senseion; Stock options: HepGene, HeptaBio; Institutional research grants: Madrigal. SAX: Institutional research grants: Target Real World Evidence. EDAT- 2026/08/30 23:36 MHDA- 2026/08/30 23:36 CRDT- 2026/08/30 19:10 PHST- 2026/03/04 00:00 [received] PHST- 2026/08/08 00:00 [revised] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/08/30 23:36 [pubmed] PHST- 2026/08/30 23:36 [medline] PHST- 2026/08/30 19:10 [entrez] AID - S2589-5559(26)00287-9 [pii] AID - 10.1016/j.jhepr.2026.102016 [doi] PST - aheadofprint SO - JHEP Rep. 2026 Aug 30:102016. doi: 10.1016/j.jhepr.2026.102016. PMID- 42668095 OWN - NLM STAT- MEDLINE DCOM- 20261010 LR - 20261014 IS - 1874-1754 (Electronic) IS - 0167-5273 (Linking) VI - 464 DP - 2026 Dec 1 TI - AI-based multimodal analysis of ECG and clinical data for evaluation for competitive sports participation: The VALETUDO trial. PG - 134744 LID - S0167-5273(26)00594-2 [pii] LID - 10.1016/j.ijcard.2026.134744 [doi] AB - AIMS: Pre-participation cardiovascular screening (PPS) is essential for preventing SCD in athletes, yet ECG interpretation requires expertise and remains resource-intensive. We aimed to evaluate the feasibility and diagnostic performance of a deep learning (DL) model for analysis of clinical data and resting 12‑lead ECG obtained during routine PPS in competitive athletes. METHODS: In this prospective single center observational study, competitive athletes aged 18 to 60 years and undergoing routine PPS were enrolled. PPS included medical history, physical examination, resting and exercise ECG. Athletes were classified as fit or not fit for competitive sports according to clinical evaluation. Resting ECG and clinical variables were analyzed using a multimodal DL architecture. Model performance was assessed using stratified 10-fold cross-validation against PPS clinical classification. RESULTS: A total of 526 athletes were enrolled (72% male, median age of 27 years (IQR: 20-41); 166 (32%) had a negative PPS result. The test setting (10-fold cross-validation), the model achieved moderate discrimination with an accuracy of 0.64 +/- 0.08, SE 0.68 +/- 0.15, SP 0.61 +/- 0.17, F1-score 0.72 +/- 0.1, PPV 0.80 +/- 0.07, NPV 0.48 +/- 0.12, AUC 0.72(0.66-0.78). Training performances reached accuracy of 0.70 +/- 0.06, SE 0.73 +/- 0.12, SP 0.67 +/- 0.14, F1-score 0.77 +/- 0.07, AUC 0.79 (0.74-0.83). CONCLUSION: Automated DL-based analysis of 12‑lead ECG during PPS is feasible and showed encouraging diagnostic performance in competitive athletes. Although wider experience and external validation is required, AI-assisted multimodal ECG interpretation may represent a useful adjunct to physician assessment for cardiovascular risk stratification in sport screening programs. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Marchetti, Davide AU - Marchetti D AD - University Cardiology and Cardiac Imaging Unit, Galeazzi-Sant'Ambrogio Hospital IRCCS, Milan, Italy; Department of Biomedical Sciences, Humanitas University, Milan, Italy. Electronic address: davide.marchetti@grupposandonato.it. FAU - Taconne, Marion AU - Taconne M AD - Department of Electronics, Informatics and Biomedical Engineering (DEIB), Politecnico di Milano, Milan, Italy. FAU - Conte, Edoardo AU - Conte E AD - University Cardiology and Cardiac Imaging Unit, Galeazzi-Sant'Ambrogio Hospital IRCCS, Milan, Italy. FAU - Quaglia, Francesca AU - Quaglia F AD - University Cardiology and Cardiac Imaging Unit, Galeazzi-Sant'Ambrogio Hospital IRCCS, Milan, Italy. FAU - Provera, Andrea AU - Provera A AD - University Cardiology and Cardiac Imaging Unit, Galeazzi-Sant'Ambrogio Hospital IRCCS, Milan, Italy. FAU - Gallazzi, Michele AU - Gallazzi M AD - University Cardiology and Cardiac Imaging Unit, Galeazzi-Sant'Ambrogio Hospital IRCCS, Milan, Italy. FAU - Paolisso, Pasquale AU - Paolisso P AD - Cardiology Unit, Sant'Andrea University Hospital, Rome, Italy; Department of Clinical and Molecular Medicine, Sapienza University of Rome, Italy. FAU - Eleonora, Melotti AU - Eleonora M AD - University Cardiology and Cardiac Imaging Unit, Galeazzi-Sant'Ambrogio Hospital IRCCS, Milan, Italy. FAU - Schillaci, Matteo AU - Schillaci M AD - University Cardiology and Cardiac Imaging Unit, Galeazzi-Sant'Ambrogio Hospital IRCCS, Milan, Italy. FAU - Bartorelli, Antonio AU - Bartorelli A AD - University Cardiology and Cardiac Imaging Unit, Galeazzi-Sant'Ambrogio Hospital IRCCS, Milan, Italy. FAU - Corino, Valentina AU - Corino V AD - Department of Electronics, Informatics and Biomedical Engineering (DEIB), Politecnico di Milano, Milan, Italy; Digital Technologies for Imaging and Sensors (LEGO) Lab, IRCCS Centro Cardiologico Monzino, Milano, Italy. FAU - Cerveri, Pietro AU - Cerveri P AD - Department of Electronics, Informatics and Biomedical Engineering (DEIB), Politecnico di Milano, Milan, Italy; Dept. of Industrial and Information Engineering, University of Pavia, Italy. FAU - Zeppilli, Paolo AU - Zeppilli P AD - Sports Medicine Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. FAU - Mainardi, Luca AU - Mainardi L AD - Department of Electronics, Informatics and Biomedical Engineering (DEIB), Politecnico di Milano, Milan, Italy. FAU - Andreini, Daniele AU - Andreini D AD - University Cardiology and Cardiac Imaging Unit, Galeazzi-Sant'Ambrogio Hospital IRCCS, Milan, Italy; Cardiology Unit, Sant'Andrea University Hospital, Rome, Italy; Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. LA - eng PT - Journal Article PT - Observational Study DEP - 20260829 PL - Netherlands TA - Int J Cardiol JT - International journal of cardiology JID - 8200291 SB - IM MH - Humans MH - *Electrocardiography/methods MH - Male MH - Adult MH - Prospective Studies MH - Female MH - Young Adult MH - Adolescent MH - *Sports/physiology MH - Middle Aged MH - *Athletes MH - *Death, Sudden, Cardiac/prevention & control MH - *Deep Learning MH - *Mass Screening/methods MH - *Artificial Intelligence MH - Feasibility Studies OTO - NOTNLM OT - Artificial intelligence OT - Athlete ECG OT - Deep learning OT - Pre-participation screening OT - Sports cardiology OT - Sudden cardiac death prevention COIS- Declaration of competing interest The authors disclose no conflict of interest. EDAT- 2026/08/29 23:35 MHDA- 2026/10/11 04:07 CRDT- 2026/08/29 19:12 PHST- 2026/06/23 00:00 [received] PHST- 2026/08/07 00:00 [revised] PHST- 2026/08/23 00:00 [accepted] PHST- 2026/10/11 04:07 [medline] PHST- 2026/08/29 23:35 [pubmed] PHST- 2026/08/29 19:12 [entrez] AID - S0167-5273(26)00594-2 [pii] AID - 10.1016/j.ijcard.2026.134744 [doi] PST - ppublish SO - Int J Cardiol. 2026 Dec 1;464:134744. doi: 10.1016/j.ijcard.2026.134744. Epub 2026 Aug 29. PMID- 42668018 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20261001 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 75 DP - 2026 Oct TI - A 12-week home-based exercise program with nutritional guidance is associated with improved functional capacity in chronic liver disease. PG - 105073 LID - S2405-4577(26)02170-4 [pii] LID - 10.1016/j.clnesp.2026.105073 [doi] AB - BACKGROUND & AIMS: Although exercise therapy improves physical function in chronic liver disease (CLD), structured programs remain underutilized in routine hepatology care. We evaluated the feasibility, safety, and potential functional impact of a structured home-based exercise program in patients with CLD. METHODS: In this prospective study, patients with CLD received guideline-based nutritional guidance, followed by a 12-week individualized home-based exercise program combining aerobic and resistance training. Primary endpoints were changes in functional capacity (6-min walking test, Liver Frailty Index, Short Physical Performance Battery), muscle strength, and muscle mass. Secondary endpoints included laboratory parameters and exercise-related adverse events. RESULTS: Among 46 patients (median age 75 years; 70% male), including 20 (46%) with cirrhosis (median Child-Pugh score 5), 43 (93%) completed the 12-week intervention. Significant improvements were observed from baseline at week 12 in 6-min walking test (Hodges-Lehmann estimate, 33 m; 95% confidence interval [CI] 14-49), Liver Frailty Index (-0.14; 95% CI, -0.23 to -0.02), and Short Physical Performance Battery (1; 95% CI, 1-2). Body weight-normalized knee extensor strength significantly increased (0.03; 95%CI, 0.01-0.06), whereas handgrip strength and skeletal muscle mass did not change. Physical activity increased after physiotherapist instruction and were maintained throughout the intervention period. No exercise-related serious adverse events or deterioration in liver functional reserves were observed. CONCLUSIONS: A home-based exercise program, combining aerobic and resistance training, with periodic adjustment by rehabilitation professionals was feasible, safe, and associated with improvements in functional capacity in patients with CLD, without adverse effects on liver functional reserves. CLINICAL TRIAL REGISTRATION: The study protocol is registered at Japan Registry of Clinical Trials (jRCT1040230078). CI - Copyright (c) 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Unome, Shinji AU - Unome S AD - Department of Gastroenterology/Internal Medicine, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan. Electronic address: unome.shinji.t7@f.gifu-u.ac.jp. FAU - Miwa, Takao AU - Miwa T AD - Department of Gastroenterology/Internal Medicine, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan; Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA, 92093, USA. Electronic address: miwa.takao.a6@f.gifu-u.ac.jp. FAU - Atago, Yoshihiko AU - Atago Y AD - Department of Rehabilitation and Orthopedics, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan. Electronic address: atago.yoshihiko.s1@f.gifu-u.ac.jp. FAU - Nakashima, Satomi AU - Nakashima S AD - Center for Nutrition Support and Infection Control, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan. Electronic address: nakashima.satomi.h9@f.gifu-u.ac.jp. FAU - Nishimura, Kayoko AU - Nishimura K AD - Center for Nutrition Support and Infection Control, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan. Electronic address: nishimura.kayoko.m1@f.gifu-u.ac.jp. FAU - Hiraoka, Shinya AU - Hiraoka S AD - Department of Gastroenterology/Internal Medicine, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan. Electronic address: hiraoka.shinya.t8@f.gifu-u.ac.jp. FAU - Aiba, Masashi AU - Aiba M AD - Department of Gastroenterology/Internal Medicine, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan. Electronic address: aiba.masashi.v4@f.gifu-u.ac.jp. FAU - Imai, Kenji AU - Imai K AD - Department of Gastroenterology/Internal Medicine, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan. Electronic address: imai.kenji.c1@f.gifu-u.ac.jp. FAU - Shirakami, Yohei AU - Shirakami Y AD - Department of Gastroenterology/Internal Medicine, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan. Electronic address: shirakami.yohei.t3@f.gifu-u.ac.jp. FAU - Takai, Koji AU - Takai K AD - Department of Gastroenterology/Internal Medicine, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan. Electronic address: takai.koji.t2@f.gifu-u.ac.jp. FAU - Aoki, Takaaki AU - Aoki T AD - Department of Rehabilitation and Orthopedics, Gifu University Hospital, 1-1 Yanagido, Gifu, 501-1194, Japan. Electronic address: aoki.takaaki.j5@f.gifu-u.ac.jp. FAU - Shimizu, Masahito AU - Shimizu M AD - Department of Gastroenterology/Internal Medicine, Graduate School of Medicine, Gifu University, 1-1 Yanagido, Gifu, 501-1194, Japan. Electronic address: shimizu.masahito.j1@f.gifu-u.ac.jp. LA - eng PT - Clinical Trial PT - Journal Article DEP - 20260829 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM MH - Aged MH - Aged, 80 and over MH - Female MH - Humans MH - Male MH - Middle Aged MH - Chronic Disease MH - *Exercise Therapy/methods MH - Feasibility Studies MH - *Liver Diseases/therapy/physiopathology MH - Muscle Strength MH - Nutritional Status MH - Prospective Studies MH - Resistance Training MH - Treatment Outcome OTO - NOTNLM OT - Cirrhosis OT - Frailty OT - Liver rehabilitation OT - Sarcopenia OT - Training COIS- Conflict of interest The authors declare that they have no conflict of interest. EDAT- 2026/08/29 23:35 MHDA- 2026/09/23 05:34 CRDT- 2026/08/29 19:11 PHST- 2026/06/27 00:00 [received] PHST- 2026/08/12 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/09/23 05:34 [medline] PHST- 2026/08/29 23:35 [pubmed] PHST- 2026/08/29 19:11 [entrez] AID - S2405-4577(26)02170-4 [pii] AID - 10.1016/j.clnesp.2026.105073 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2026 Oct;75:105073. doi: 10.1016/j.clnesp.2026.105073. Epub 2026 Aug 29. PMID- 42667824 OWN - NLM STAT- MEDLINE DCOM- 20261028 LR - 20261028 IS - 1532-7361 (Electronic) IS - 0039-6060 (Linking) VI - 199 DP - 2026 Nov TI - Direct lymphangiography-guided cervical thoracic duct exploration for isolated primary chylopericardium: Abnormal reflux patterns and long-term outcomes. PG - 110520 LID - S0039-6060(26)00445-9 [pii] LID - 10.1016/j.surg.2026.110520 [doi] AB - BACKGROUND: Primary chylopericardium is a rare lymphatic disorder with poorly defined pathophysiology and limited treatment options. This study aimed to characterize lymphangiographic reflux patterns and evaluate the long-term outcomes and predictors of success of direct lymphangiography-guided cervical thoracic duct exploration. METHODS: We retrospectively reviewed 67 patients with isolated primary chylopericardium who underwent direct lymphangiography between June 2007 and December 2020. A novel 4-type classification of abnormal reflux pathways was proposed based on direct lymphangiography findings. Treatment success was defined as resolution or marked reduction of pericardial effusion, relief of symptoms, and no need for reintervention. Median follow-up was 10.2 years (range, 7.5-19.5 years). Multivariable logistic regression was performed to identify independent predictors of success. RESULTS: Direct lymphangiography demonstrated distinct reflux patterns: type I (bronchomediastinal trunk, 55.2%), type II (thoracic segment, 11.9%), type III (combined, 7.5%), and type IV (no identifiable pathway, 28.4%). Compensatory drainage was present in 25.4% of patients. Among 65 patients who underwent cervical thoracic duct exploration, the clinical success rate was 66.2% (43/65), with no major complications. Multivariable analysis showed that the absence of compensatory drainage pathways was the strongest independent predictor of success (adjusted odds ratio, 7.85; 95% confidence interval, 1.48-41.6; P = .016). Reflux pathway type was also independently associated with outcome (P = .012), with type I demonstrating better results than types II-IV. Conservative dietary management alone was ineffective in the 2 patients who did not undergo surgery. CONCLUSION: Direct lymphangiography-guided cervical thoracic duct exploration is associated with favorable long-term outcomes in selected patients with primary chylopericardium. The proposed reflux classification and the absence of compensatory drainage pathways were strong predictors of success. These findings are preliminary and require prospective multicenter validation. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Xin, Jianfeng AU - Xin J AD - Department of Lymphatic Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. FAU - Dong, Chao AU - Dong C AD - Department of Ultrasound, Sanfine International Hospital, Beijing, China. FAU - Xia, Song AU - Xia S AD - Department of Lymphatic Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. FAU - Sun, Yuguang AU - Sun Y AD - Department of Lymphatic Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. FAU - Chang, Kun AU - Chang K AD - Department of Lymphatic Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. FAU - Xu, Ke AU - Xu K AD - Department of Lymphatic Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. FAU - Jiang, Wenxiang AU - Jiang W AD - Department of Lymphatic Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. FAU - Li, Peilin AU - Li P AD - Department of Lymphatic Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. FAU - Shen, Wenbin AU - Shen W AD - Department of Lymphatic Surgery, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. Electronic address: xinjianfeng@bjsjth.cn. LA - eng PT - Journal Article DEP - 20260810 PL - United States TA - Surgery JT - Surgery JID - 0417347 SB - IM MH - Humans MH - *Thoracic Duct/diagnostic imaging/surgery MH - Female MH - *Pericardial Effusion/surgery/diagnostic imaging/diagnosis/etiology MH - Retrospective Studies MH - *Lymphography/methods MH - Male MH - Treatment Outcome MH - Follow-Up Studies MH - Child MH - Adolescent MH - Child, Preschool MH - Adult MH - Infant MH - Middle Aged COIS- Conflict of Interest/Disclosure The authors declare that they have no competing interests. EDAT- 2026/08/29 23:35 MHDA- 2026/10/28 23:26 CRDT- 2026/08/29 18:05 PHST- 2026/06/21 00:00 [received] PHST- 2026/08/01 00:00 [revised] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/10/28 23:26 [medline] PHST- 2026/08/29 23:35 [pubmed] PHST- 2026/08/29 18:05 [entrez] AID - S0039-6060(26)00445-9 [pii] AID - 10.1016/j.surg.2026.110520 [doi] PST - ppublish SO - Surgery. 2026 Nov;199:110520. doi: 10.1016/j.surg.2026.110520. Epub 2026 Aug 10. PMID- 42667449 OWN - NLM STAT- MEDLINE DCOM- 20260829 LR - 20261008 IS - 1573-7373 (Electronic) IS - 0167-594X (Linking) VI - 179 IP - 2 DP - 2026 Aug 29 TI - Extent of resection and craniopharyngioma recurrence: a volumetric analysis. LID - 65 [pii] LID - 10.1007/s11060-026-05770-6 [doi] AB - PURPOSE: The optimal extent of resection (EOR) required to minimize recurrence risk in craniopharyngioma remains unclear. The objective of this study was to quantitatively evaluate postoperative tumor volume and EOR as determinants of progression-free survival (PFS) in surgically treated adamantinomatous craniopharyngiomas. METHODS: We retrospectively measured pre- and post-surgical tumor volumes in 60 patients using manual MRI-based segmentation. None received planned adjuvant radiotherapy. The median follow-up duration was 5 years. Clinical and volumetric variables were analyzed using Cox proportional hazards regression. Time-dependent receiver operating characteristic analysis at 3 years was also performed. RESULTS: Tumor progression/recurrence occurred in 60% of patients. On univariable analysis, EOR was associated with improved PFS (HR 0.981 per 1% increase; 95% CI 0.966-0.997; p = 0.018), whereas increasing TV(solid) (HR 1.178 per 1 cc increase; 95% CI 1.041-1.334; p = 0.010), residual cystic disease (HR 3.600; 95% CI 1.788-7.249; p < 0.001), and preoperative tumor volume (HR 1.006 per 1 cc increase; 95% CI 1.000-1.013; p = 0.044) were associated with increased progression risk. Given collinearity between EOR and TV(solid), separate multivariable models were constructed. EOR and TV(solid) remained significantly associated with progression in their respective models, and residual cystic disease was associated with progression in both models. Optimism-corrected AUCs were 0.777 (95% CI, 0.649-0.927) for EOR and 0.813 (95% CI, 0.691-0.953) for TV(solid). CONCLUSIONS: EOR, TV(solid) and the presence of residual cystic disease are independently associated with progression after craniopharyngioma resection. Risk stratification using tumor volumetry may help individualize postoperative decision-making in terms of surveillance versus adjuvant radiotherapy. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Sarkar, Sauradeep AU - Sarkar S AD - Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences, Whitefield, Bengaluru, India. sauradeepsarkar@gmail.com. FAU - Vijayaraghavan, Sudharsan AU - Vijayaraghavan S AD - Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences, Whitefield, Bengaluru, India. FAU - Thakar, Sumit AU - Thakar S AD - Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences, Whitefield, Bengaluru, India. FAU - Aryan, Saritha AU - Aryan S AD - Department of Neurosurgery, Sri Sathya Sai Institute of Higher Medical Sciences, Whitefield, Bengaluru, India. LA - eng PT - Journal Article DEP - 20260829 PL - United States TA - J Neurooncol JT - Journal of neuro-oncology JID - 8309335 SB - IM MH - Humans MH - *Craniopharyngioma/surgery/pathology/diagnostic imaging MH - Female MH - *Neoplasm Recurrence, Local/pathology/surgery MH - *Pituitary Neoplasms/surgery/pathology/diagnostic imaging MH - Retrospective Studies MH - Male MH - Magnetic Resonance Imaging MH - Follow-Up Studies MH - Adult MH - Tumor Burden MH - Adolescent MH - Middle Aged MH - Young Adult MH - *Neurosurgical Procedures MH - Child MH - Prognosis OTO - NOTNLM OT - Craniopharyngioma OT - Extent of resection OT - Recurrence OT - Volumetric analysis COIS- Declaration. Ethics approval and consent: The Institutional Review Board granted a waiver of informed consent due to the retrospective design and use of de-identified data. Competing interests: The authors declare no competing interests. EDAT- 2026/08/29 17:36 MHDA- 2026/08/29 17:37 CRDT- 2026/08/29 11:17 PHST- 2026/07/18 00:00 [received] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/08/29 17:37 [medline] PHST- 2026/08/29 17:36 [pubmed] PHST- 2026/08/29 11:17 [entrez] AID - 10.1007/s11060-026-05770-6 [pii] AID - 10.1007/s11060-026-05770-6 [doi] PST - epublish SO - J Neurooncol. 2026 Aug 29;179(2):65. doi: 10.1007/s11060-026-05770-6. PMID- 42666228 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260829 LR - 20261008 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Acute gastrointestinal injury severity assessment informs nutritional support and prognostic evaluation in critically ill children: a narrative review. PG - 1911973 LID - 10.3389/fnut.2026.1911973 [doi] LID - 1911973 AB - Acute gastrointestinal injury (AGI) affects 41-65% of children admitted to pediatric intensive care units (PICUs) and is associated with prolonged mechanical ventilation, extended hospital stays, multiple organ dysfunction, and increased mortality. Although the 2012 European Society of Intensive Care Medicine (ESICM) AGI grading system provides standardized gastrointestinal assessment for adults, no validated pediatric-specific tool currently exists. This narrative review critically synthesizes the prognostic and nutritional relevance of AGI severity assessment in critically ill children. A structured literature search of PubMed, Embase, Web of Science, Google Scholar, Cochrane Library, CINAHL, CNKI, and Wanfang Data through December 2025 yielded 78 peer-reviewed articles, guidelines, and consensus statements. Two reviewers independently screened records; evidence was appraised narratively with explicit attention to study design and methodological quality, assigning greater weight to multicenter prospective studies, pediatric guidelines, and meta-analyses (level I-II evidence). No formal quality assessment, consensus methodology, or systematic evidence synthesis was performed, consistent with narrative review methodology. Existing pediatric adaptations of adult AGI criteria have been reported in single-center and observational studies and include reported thresholds for gastric residual volume (>5 mL/kg), intra-abdominal pressure gradations, and feeding intolerance definitions. Higher AGI severity is consistently associated with increased mortality, prolonged mechanical ventilation, and greater multiple organ dysfunction syndrome. Synthesis of AGI severity concepts with pediatric nutrition guidelines suggests that early enteral nutrition appears feasible in mild dysfunction, whereas severe grades may warrant cautious parenteral supplementation with dynamic reassessment. This review identifies critical gaps: the absence of multicenter validation, the subjective nature of grading variables, and the lack of age-stratified nutritional trials. In conclusion, AGI severity assessment holds conceptual promise for risk stratification and nutritional guidance in pediatric intensive care, but requires formal consensus methodology, systematic evidence synthesis, and prospective validation before clinical adoption. CI - Copyright (c) 2026 Zeng, Li, Wu, Rong, Liu, Chen, Cai, Zhang, Li and Liu. FAU - Zeng, Cizheng AU - Zeng C AD - Pediatric Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Li, Tufeng AU - Li T AD - Pediatric Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Wu, Jiayuan AU - Wu J AD - Department of Scientific Research, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Rong, Shiwen AU - Rong S AD - Pediatric Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Liu, Xiaohua AU - Liu X AD - Pediatric Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Chen, Yinhui AU - Chen Y AD - Pediatric Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Cai, Nali AU - Cai N AD - Pediatric Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Zhang, Limei AU - Zhang L AD - Pediatric Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Li, Wen AU - Li W AD - Pediatric Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Liu, Ling AU - Liu L AD - Pediatric Intensive Care Unit, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. LA - eng PT - Journal Article PT - Review DEP - 20260814 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 EIN - Front Nutr. 2026 Sep 23;13:1989398. doi: 10.3389/fnut.2026.1989398. PMID: 42846160 PMC - PMC13521867 OTO - NOTNLM OT - critical illness OT - enteral feeding OT - feeding intolerance OT - gastric residual volume OT - intra-abdominal hypertension OT - multiple organ dysfunction OT - nutritional support OT - pediatric intensive care COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/29 05:35 MHDA- 2026/08/29 05:36 PMCR- 2026/08/14 CRDT- 2026/08/29 04:39 PHST- 2026/06/17 00:00 [received] PHST- 2026/07/23 00:00 [revised] PHST- 2026/07/24 00:00 [accepted] PHST- 2026/08/29 05:36 [medline] PHST- 2026/08/29 05:35 [pubmed] PHST- 2026/08/29 04:39 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - 10.3389/fnut.2026.1911973 [doi] PST - epublish SO - Front Nutr. 2026 Aug 14;13:1911973. doi: 10.3389/fnut.2026.1911973. eCollection 2026. PMID- 42666156 OWN - NLM STAT- MEDLINE DCOM- 20260829 LR - 20260908 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Scale-up of the Diactive-1 mHealth program integrating tailored resistance training as an educational strategy for self-management in children and adolescents with type 1 diabetes: protocol for an 11-hospital multicenter randomized controlled trial. PG - 1913568 LID - 10.3389/fendo.2026.1913568 [doi] LID - 1913568 AB - INTRODUCTION: Physical activity is strongly recommended for youth with type 1 diabetes, yet many children and adolescents do not meet current exercise guidelines, partly because of fear of hypoglycemia. Resistance training may offer metabolic and musculoskeletal benefits, but its implementation in routine pediatric diabetes care remains limited. Diactive-1 is an mHealth program designed to deliver tailored resistance-training sessions combined with glucose-management educational support. This multicenter trial aims to evaluate the effectiveness of Diactive-1 (v2.0) in improving hangrip strength in children and adolescents with type 1 diabetes. METHODS: This study is a 12-week, parallel-group, multicenter randomized controlled trial conducted across 11 Spanish pediatric endocrinology units. The target sample size is 158 children and adolescents aged 10-18 years with type 1 diabetes, with 79 participants allocated to each group. Participants will be randomized to either the Diactive-1 intervention or usual clinical care. The intervention group will use the Diactive-1 (v2.0) app, which provides individualized resistance-training programs, glucose-related educational prompts, safety thresholds for exercise, and engagement strategies such as gamification. The primary outcome will be the change in age- and sex-standardized handgrip strength z-score from baseline to 12 weeks. Secondary outcomes will include glycemic stability, insulin requirements, cardiometabolic markers, physical literacy, quality of life, psychological well-being, app usability, and intervention engagement. Analyses will follow the intention-to-treat principle using mixed-effects models. EXPECTED OUTCOMES AND DISCUSSION: This trial will assess whether a scalable mHealth-supported resistance-training program can improve muscular strength and support diabetes self-management in routine pediatric care. By testing Diactive-1 across multiple hospitals and real-world settings, the study will provide evidence on the external validity, feasibility, and potential clinical integration of digitally supported exercise education for youth with type 1 diabetes. ETHICS AND DISSEMINATION: Ethical approval was granted by the Research Ethics Committee for Medicinal Products of the Government of Navarra. Written informed consent will be obtained from parents or legal guardians, with age-appropriate assent from minors. Findings will be disseminated through scientific conferences, peer-reviewed publications, and summaries shared with participating families. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/study/NCT07290868, identifier NCT07290868. CI - Copyright (c) 2026 Sanchez-Arlegui, Munoz-Pardeza, Hormazabal-Aguayo, Abio-Abero, Bertholt-Zuber, Alonso-Rubio, Burillo-Sanchez, Chueca-Guindulain, Cifuentes-Zamalloa, Congost-Marin, Diez-Lopez, Ferrer-Lozano, Garcia-Navas, Gonzalez-Garcia, Huidobro-Fernandez, Lalaguna-Mallada, Llorente-Cereza, Maeso-Mendez, Riano-Galan, Ruiz-del Campo, Salcedo Fresneda, Vara-Callau, Vela-Desojo, Ezzatvar and Garcia-Hermoso. FAU - Sanchez-Arlegui, Amaia AU - Sanchez-Arlegui A AD - Public Healthcare Service of Navarra-Osasunbidea (SNS-O), Universidad Publica de Navarra (UPNA), Pamplona, Spain. FAU - Munoz-Pardeza, Jacinto AU - Munoz-Pardeza J AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain. FAU - Hormazabal-Aguayo, Ignacio AU - Hormazabal-Aguayo I AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain. AD - Office of the Vice-Rector for Research and Graduate Studies, Universidad de La Serena, La Serena, Chile. FAU - Abio-Abero, Sonia AU - Abio-Abero S AD - Pediatrics Service, Hospital San Jorge, Huesca, Spain. FAU - Bertholt-Zuber, Maria Laura AU - Bertholt-Zuber ML AD - Pediatric Endocrinology Unit, Hospital Universitario Marques de Valdecilla, Santander, Spain. FAU - Alonso-Rubio, Pablo AU - Alonso-Rubio P AD - Pediatric Endocrinology Unit, Hospital Universitario Marques de Valdecilla, Santander, Spain. FAU - Burillo-Sanchez, Elisabet AU - Burillo-Sanchez E AD - Pediatric Endocrinology Unit, Hospital Universitario de Navarra, Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain. FAU - Chueca-Guindulain, Maria J AU - Chueca-Guindulain MJ AD - Pediatric Endocrinology Unit, Hospital Universitario de Navarra, Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain. FAU - Cifuentes-Zamalloa, Claudia AU - Cifuentes-Zamalloa C AD - Pediatric Endocrinology Unit, Hospital Universitario Cruces, Barakaldo, Spain. FAU - Congost-Marin, Sofia AU - Congost-Marin S AD - Pediatric Endocrinology Unit, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain. FAU - Diez-Lopez, Ignacio AU - Diez-Lopez I AD - Pediatrics Service, Hospital de Araba, Vitoria, Spain. FAU - Ferrer-Lozano, Marta AU - Ferrer-Lozano M AD - Pediatric Endocrinology Unit, Hospital Infantil Miguel Servet, Zaragoza, Spain. FAU - Garcia-Navas, Patricia AU - Garcia-Navas P AD - Pediatrics Service, Hospital San Pedro, Logrono, Spain. FAU - Gonzalez-Garcia, Lara Gloria AU - Gonzalez-Garcia LG AD - Pediatrics Service, Hospital de Cabuenes, Gijon, Spain. FAU - Huidobro-Fernandez, Belen AU - Huidobro-Fernandez B AD - Pediatrics Service, Hospital de Cabuenes, Gijon, Spain. FAU - Lalaguna-Mallada, Paula AU - Lalaguna-Mallada P AD - Pediatrics Service, Hospital de Barbastro, Huesca, Spain. FAU - Llorente-Cereza, Maria Teresa AU - Llorente-Cereza MT AD - Pediatric Endocrinology Unit, Hospital Universitario de Navarra, Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain. FAU - Maeso-Mendez, Sandra AU - Maeso-Mendez S AD - Pediatrics Service, Hospital de Araba, Vitoria, Spain. FAU - Riano-Galan, Isolina AU - Riano-Galan I AD - Pediatric Endocrinology Unit, Hospital Universitario Central de Asturias, Oviedo, Spain. FAU - Ruiz-Del Campo, Maria AU - Ruiz-Del Campo M AD - Pediatrics Service, Hospital San Pedro, Logrono, Spain. FAU - Salcedo Fresneda, Oihane AU - Salcedo Fresneda O AD - Pediatric Endocrinology Unit, Hospital Universitario Central de Asturias, Oviedo, Spain. FAU - Vara-Callau, Marta AU - Vara-Callau M AD - Pediatric Endocrinology Unit, Hospital Infantil Miguel Servet, Zaragoza, Spain. FAU - Vela-Desojo, Amaia AU - Vela-Desojo A AD - Pediatric Endocrinology Unit, Hospital Universitario Cruces, Barakaldo, Spain. FAU - Ezzatvar, Yasmin AU - Ezzatvar Y AD - Lifestyle factors with impact on Ageing and overall Health (LAH) Research Group, Departamento de Enfermeria, Universidad de Valencia, Valencia, Spain. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno, Chile. FAU - Garcia-Hermoso, Antonio AU - Garcia-Hermoso A AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Pamplona, Spain. LA - eng SI - ClinicalTrials.gov/NCT07290868 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260814 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/therapy MH - Child MH - Adolescent MH - *Resistance Training/methods MH - Multicenter Studies as Topic MH - Female MH - *Self-Management/education/methods MH - Male MH - Randomized Controlled Trials as Topic MH - *Patient Education as Topic/methods MH - Telemedicine MH - Quality of Life PMC - PMC13521802 OTO - NOTNLM OT - digital health OT - education OT - mHealth OT - strength training OT - type 1 diabetes COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/29 05:35 MHDA- 2026/08/29 05:36 PMCR- 2026/08/14 CRDT- 2026/08/29 04:31 PHST- 2026/06/19 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/29 05:36 [medline] PHST- 2026/08/29 05:35 [pubmed] PHST- 2026/08/29 04:31 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - 10.3389/fendo.2026.1913568 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Aug 14;17:1913568. doi: 10.3389/fendo.2026.1913568. eCollection 2026. PMID- 42665290 OWN - NLM STAT- Publisher LR - 20260828 IS - 1552-6127 (Electronic) IS - 1090-1981 (Linking) DP - 2026 Aug 28 TI - A Therapeutic Exercise Programme for Trans and Gender Diverse Youth: An Effectiveness-Implementation Trial. PG - 10901981261479283 LID - 10.1177/10901981261479283 [doi] AB - Trans young people face systemic barriers to physical activity participation and experience disproportionately higher rates of physical and mental health challenges compared with their cisgender peers, yet evidence-based exercise interventions tailored to this population remain limited. This study evaluated a 12-week structured, group-based, gender-affirming exercise programme for trans youth aged 12 to 24 years in Western Australia, recruited through a specialist paediatric gender diversity service and community-based health and well-being services. Using a nonrandomised effectiveness-implementation hybrid design, the study assessed both the real-world implementation outcomes and health-related effectiveness of the programme, which was collaboratively designed with trans young people, families, and health professionals and grounded in international physical activity guidelines. Twenty participants enrolled, with 18 completing postprogramme assessments. Quantitative analysis revealed modest improvements in muscular strength, endurance, power, aerobic recovery, and well-being from baseline to 12 weeks, alongside high acceptability, appropriateness, feasibility, fidelity, and retention rates. Qualitative analysis identified themes relating to pathways to participation, connection through shared experience, supportive facilitation, and perceived physical and psychological benefits. This study adds to the limited evidence base by demonstrating that gender-affirming exercise programmes are both feasible and acceptable across clinical and community settings. Findings support the broader integration of exercise into gender-affirming health care, with implications for the design of inclusive health services and physical activity policies that address the specific needs of trans youth. FAU - Austin, Felicity AU - Austin F AUID- ORCID: 0009-0004-1287-8280 AD - The University of Western Australia, Perth, Australia. AD - The Kids Research Institute Australia, Perth, Western Australia, Australia. AD - Thriving in Motion, Perth, Western Australia, Australia. FAU - Wright, Kemi AU - Wright K AUID- ORCID: 0000-0002-7146-0835 AD - The University of Western Australia, Perth, Australia. AD - Thriving in Motion, Perth, Western Australia, Australia. AD - University of New South Wales, Sydney, Australia. FAU - Lin, Ashleigh AU - Lin A AD - The University of Western Australia, Perth, Australia. AD - La Trobe University, Bundoora, Victoria, Australia. FAU - Jackson, Ben AU - Jackson B AD - The University of Western Australia, Perth, Australia. AD - The Kids Research Institute Australia, Perth, Western Australia, Australia. FAU - Moore, Julia K AU - Moore JK AD - The University of Western Australia, Perth, Australia. AD - Perth Children's Hospital, Western Australia, Australia. FAU - Saunders, Liz AU - Saunders L AD - The University of Western Australia, Perth, Australia. AD - Perth Children's Hospital, Western Australia, Australia. FAU - Laming, Bridget AU - Laming B AD - The University of Western Australia, Perth, Australia. AD - Thriving in Motion, Perth, Western Australia, Australia. FAU - Munsie, Claire AU - Munsie C AD - Curtin University, Perth, Western Australia, Australia. FAU - Kramer, Ben AU - Kramer B AD - The University of Western Australia, Perth, Australia. AD - Thriving in Motion, Perth, Western Australia, Australia. AD - South Metropolitan Health Service, Fremantle, Western Australia, Australia. FAU - Quick, Ben AU - Quick B AD - The University of Western Australia, Perth, Australia. AD - Thriving in Motion, Perth, Western Australia, Australia. FAU - Almarjawi, Ashley AU - Almarjawi A AD - Thriving in Motion, Perth, Western Australia, Australia. FAU - Simpson, Aaron AU - Simpson A AUID- ORCID: 0000-0002-0660-488X AD - The University of Western Australia, Perth, Australia. AD - The Kids Research Institute Australia, Perth, Western Australia, Australia. FAU - Furzer, Bonnie AU - Furzer B AUID- ORCID: 0000-0002-0321-6988 AD - The University of Western Australia, Perth, Australia. AD - The Kids Research Institute Australia, Perth, Western Australia, Australia. AD - Thriving in Motion, Perth, Western Australia, Australia. AD - South Metropolitan Health Service, Fremantle, Western Australia, Australia. LA - eng PT - Journal Article DEP - 20260828 PL - United States TA - Health Educ Behav JT - Health education & behavior : the official publication of the Society for Public Health Education JID - 9704962 SB - IM OTO - NOTNLM OT - adolescents OT - exercise therapy OT - gender identity OT - health OT - physical fitness OT - transgender person EDAT- 2026/08/28 23:34 MHDA- 2026/08/28 23:34 CRDT- 2026/08/28 20:32 PHST- 2026/08/28 23:34 [medline] PHST- 2026/08/28 23:34 [pubmed] PHST- 2026/08/28 20:32 [entrez] AID - 10.1177/10901981261479283 [doi] PST - aheadofprint SO - Health Educ Behav. 2026 Aug 28:10901981261479283. doi: 10.1177/10901981261479283. PMID- 42665051 OWN - NLM STAT- MEDLINE DCOM- 20261005 LR - 20261005 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 124 IP - 4 DP - 2026 Oct TI - Major dietary protein sources during pregnancy and obesity risk in mothers and offspring: A prospective cohort study. PG - 101508 LID - S0002-9165(26)00317-5 [pii] LID - 10.1016/j.ajcnut.2026.101508 [doi] AB - BACKGROUND: Maternal protein intake during pregnancy may influence long-term obesity risk in mothers and offspring, but the role of specific dietary protein sources remains unclear. OBJECTIVES: This study aimed to examine the associations of major dietary protein sources during pregnancy with maternal postpartum weight retention (PPWR) and offspring overweight/obesity, and to evaluate isocaloric substitution between sources. METHODS: In 59,791 mothers from the Danish National Birth Cohort (1996-2002), diet at 25 wk of gestation was assessed by a validated food-frequency questionnaire. Log-binomial regression and isocaloric substitution models estimated adjusted relative risks (RRs) for maternal PPWR >5 kg at 6-18 mo postpartum and offspring overweight/obesity at ages 7-11 y. RESULTS: Overall, 10,678 (22.1%) mothers had PPWR >5 kg, and 8287 (19.0%) offspring developed overweight/obesity. Comparing highest with lowest quintile of intake (% energy), higher total plant [RR: 0.86; 95% confidence interval (CI): 0.81, 0.91], grain (RR: 0.87; 95% CI: 0.82, 0.91), legume and nut (RR: 0.93; 95% CI: 0.88, 0.98), poultry (RR: 0.90; 95% CI: 0.85, 0.95), and fish protein (RR: 0.90; 95% CI: 0.86, 0.95) were associated with lower maternal PPWR risk, whereas higher red meat protein intake with higher risk (RR: 1.11; 95% CI: 1.05, 1.17). For offspring overweight/obesity, higher total animal (RR: 1.12; 95% CI: 1.05, 1.19), red meat (RR: 1.06; 95% CI: 1.00, 1.13), and dairy protein (RR: 1.11; 95% CI: 1.04, 1.17) were associated with higher risk, whereas poultry (RR: 0.95; 95% CI: 0.89, 0.99) and fish protein (RR: 0.93; 95% CI: 0.88, 0.99) with modestly lower risk. Replacing 1% of energy from total animal protein with plant protein, or from red meat or dairy protein with poultry, fish, or grain protein, was associated with 4%-6% lower maternal PPWR risk; corresponding substitutions with poultry or fish protein were associated with 3%-4% lower offspring risk. CONCLUSIONS: During pregnancy, substituting poultry or fish protein for red meat or dairy protein was associated with lower risks of both maternal PPWR and offspring overweight/obesity, supporting consideration of protein source in food-based dietary guidance. CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Zhang, Hanyue AU - Zhang H AD - Research Unit for Diet and Health, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark; Global Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. Electronic address: hanyue.zhang@nus.edu.sg. FAU - Zheng, Miaobing AU - Zheng M AD - School of Health Sciences, Faculty of Health & Medicine, University of New South Wales, Sydney, Australia. FAU - Halldorsson, Thornorhallur I AU - Halldorsson ThornI AD - Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark; Faculty of Food Science and Nutrition, University of Iceland, Reykjavik, Iceland. FAU - Olsen, Sjurdur F AU - Olsen SF AD - Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, United States. FAU - Simpson, Stephen J AU - Simpson SJ AD - Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia. FAU - Raubenheimer, David AU - Raubenheimer D AD - Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia; School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia. FAU - Heitmann, Berit L AU - Heitmann BL AD - Research Unit for Diet and Health, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Denmark; Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia; Section for General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark; Faculty of Health, Deakin University, Melbourne, Victoria, Australia. Electronic address: Berit.Lilienthal.Heitmann@regionh.dk. LA - eng PT - Journal Article DEP - 20260911 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 RN - 0 (Dietary Proteins) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Dietary Proteins/administration & dosage MH - *Obesity/etiology/epidemiology MH - Prospective Studies MH - Denmark/epidemiology MH - Adult MH - Child MH - *Maternal Nutritional Physiological Phenomena MH - Diet MH - Risk Factors MH - Overweight/etiology/epidemiology MH - Postpartum Period MH - Cohort Studies OTO - NOTNLM OT - Danish National Birth Cohort OT - childhood obesity OT - dietary protein OT - postpartum weight retention OT - pregnancy OT - protein source OT - substitution analysis COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/08/28 23:34 MHDA- 2026/10/05 23:29 CRDT- 2026/08/28 19:11 PHST- 2026/05/09 00:00 [received] PHST- 2026/08/21 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/10/05 23:29 [medline] PHST- 2026/08/28 23:34 [pubmed] PHST- 2026/08/28 19:11 [entrez] AID - S0002-9165(26)00317-5 [pii] AID - 10.1016/j.ajcnut.2026.101508 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Oct;124(4):101508. doi: 10.1016/j.ajcnut.2026.101508. Epub 2026 Sep 11. PMID- 42664710 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20260918 IS - 1878-3252 (Electronic) IS - 0946-672X (Linking) VI - 97 DP - 2026 Oct TI - Hair iron-manganese balance in a large pediatric autism spectrum disorder cohort: Coordinated variation and an exploratory low-Fe/high-Mn subgroup. PG - 127943 LID - S0946-672X(26)00129-X [pii] LID - 10.1016/j.jtemb.2026.127943 [doi] AB - BACKGROUND: Iron (Fe) and manganese (Mn) are essential metals that share several transport and regulatory pathways. Reduced Fe status may increase Mn uptake and retention, potentially increasing susceptibility to Mn-associated neurotoxicity. Children with autism spectrum disorder (ASD) frequently have selective diets and micronutrient inadequacies, but the relationship between hair Fe and Mn has received limited attention. OBJECTIVES: This study aimed to describe age- and sex-specific distributions of hair Fe and Mn in a large pediatric ASD cohort, evaluate the association between the two elements, and explore the occurrence of a subgroup with relatively low hair Fe and relatively high hair Mn. METHODS: This retrospective cross-sectional study analyzed pre-existing hair trace-element records from a commercial laboratory for 2151 children and adolescents with an ASD diagnosis recorded in the laboratory datasets, including 1808 boys and 343 girls aged 0-18 years. Individual diagnostic records were unavailable, and the recorded diagnoses could not be independently verified. The laboratory-referred cohort was not population-representative, and no neurotypical control group was available. Hair Fe and Mn were measured by inductively coupled plasma mass spectrometry and reported in mg/100 g hair. Distributions were summarized by sex and two-year age bands. Associations between natural-log-transformed Fe and Mn were examined using correlation and linear regression adjusted for age and sex. An exploratory low-Fe/high-Mn subgroup was defined using cohort-relative thresholds of hair Fe /= 0.042 mg/100 g. RESULTS: Median hair Fe was 0.8 mg/100 g, and median hair Mn was 0.024 mg/100 g. Concentrations showed little consistent variation across age groups or between boys and girls. Log-transformed Fe and Mn were strongly positively correlated (r = 0.66). In linear regression, log Fe was positively associated with log Mn (beta = 1.22; 95% CI, 1.16-1.28; p < 0.001), and the association was unchanged after adjustment for age and sex. The model explained 44% of the variability in log Mn. The exploratory low-Fe/high-Mn subgroup comprised 62 participants (2.9%) and had a markedly lower median Fe:Mn ratio than the remaining cohort. More stringent sensitivity definitions identified progressively smaller subgroups. CONCLUSIONS: Hair Fe and Mn concentrations were strongly and positively associated in this pediatric ASD cohort, rather than showing the inverse relationship that might be expected from Fe deficiency-related Mn accumulation. A small, threshold-dependent subgroup had relatively low hair Fe, relatively high hair Mn, and a reduced Fe:Mn ratio. These hair-based patterns should not be interpreted as evidence of systemic Fe deficiency, excessive Mn exposure, or a distinct clinical phenotype. Future studies should combine standardized hair analysis with established Fe-status biomarkers, direct measures of Mn exposure, dietary and supplementation data, appropriate control groups, and validated neurodevelopmental assessments. CI - Copyright (c) 2026 Elsevier GmbH. All rights reserved. FAU - Bjorklund, Geir AU - Bjorklund G AD - Council for Nutritional and Environmental Medicine, Mo i Rana, Norway. Electronic address: bjorklund@conem.org. FAU - Watts, David AU - Watts D AD - Trace Elements, Inc, Addison, TX, USA. LA - eng PT - Journal Article DEP - 20260818 PL - Germany TA - J Trace Elem Med Biol JT - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JID - 9508274 RN - 42Z2K6ZL8P (Manganese) RN - E1UOL152H7 (Iron) SB - IM MH - Humans MH - *Hair/chemistry/metabolism MH - *Manganese/analysis/metabolism MH - *Iron/analysis/metabolism MH - Male MH - Female MH - Child MH - Child, Preschool MH - Adolescent MH - *Autism Spectrum Disorder/metabolism MH - Infant MH - Retrospective Studies MH - Cross-Sectional Studies MH - Cohort Studies MH - Infant, Newborn OTO - NOTNLM OT - Autism spectrum disorder OT - Hair OT - ICP-MS OT - Iron OT - Manganese OT - Neurodevelopment OT - Pediatric OT - Trace elements COIS- Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests. Geir Bjorklund has no competing financial interests or personal relationships that could have influenced the work reported in this paper. David Watts is the director of research at Trace Elements, Inc, Addison, TX, USA. EDAT- 2026/08/28 23:34 MHDA- 2026/09/18 23:36 CRDT- 2026/08/28 18:06 PHST- 2026/02/15 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/08/11 00:00 [accepted] PHST- 2026/09/18 23:36 [medline] PHST- 2026/08/28 23:34 [pubmed] PHST- 2026/08/28 18:06 [entrez] AID - S0946-672X(26)00129-X [pii] AID - 10.1016/j.jtemb.2026.127943 [doi] PST - ppublish SO - J Trace Elem Med Biol. 2026 Oct;97:127943. doi: 10.1016/j.jtemb.2026.127943. Epub 2026 Aug 18. PMID- 42663907 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20261008 IS - 1867-0687 (Electronic) VI - 22 IP - 7 DP - 2026 Jul TI - Waist-to-height ratio as a practical indicator for screening pediatric metabolic dysfunction-associated steatotic liver disease in diverse populations and genetic backgrounds. PG - 805-818 LID - 10.1007/s12519-026-01084-9 [doi] AB - BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading chronic liver disease in children and adolescents; this parallels the global obesity epidemic. The contribution of genetic susceptibility to pediatric MASLD, and its interaction with anthropometric and biochemical indices used for non-invasive screening remains poorly understood. We aimed to evaluate waist-to-height ratio (WHtR) as a simple, equitable, and scalable tool for early identification of pediatric MASLD and relate this to genetic risk. METHODS: We combined school-based data from 1010 Chinese children with analyses of the Global Burden of Disease, the 1000 Genomes Project, and the US National Health and Nutrition Examination Survey (NHANES). Thirteen MASLD-related single-nucleotide polymorphisms (SNPs) were genotyped to construct a genetic risk score (GRS). We examined global epidemiological patterns, quantified inter-population allele divergence, and assessed how GRS modifies cutoffs and performance of nine anthropometric and biochemical indices. RESULTS: Genetic analysis revealed minimal frequency divergence across most ancestries (mean Fixation index < 0.05), except for the African ancestry where there was moderate divergence. Higher GRS were associated with lower cutoffs across indices. When GRS Z-score increased from -3 to 3, visceral adiposity index showed the sharpest changes (Z-score decreased from 1.5 to -1.8), while BFP (1.2 to 0.1) and WHtR (1.5 to 0.1) showed gradual change. Furthermore, incorporating GRS into the base anthropometric models yielded only marginal improvements in overall screening performance [area under the receiver operating characteristic curve (AUC) and Youden Index]. Validation in NHANES showed WHtR >/= 0.48 retained high discrimination (AUC > 0.87) across most genetic variants. CONCLUSIONS: This study suggests that WHtR is a consistent and practical tool for screening pediatric patients with MASLD across diverse populations. While genetic variation may influence optimal thresholds, WHtR >/= 0.48 appears broadly applicable, supporting its potential use as a frontline screening metric in diverse settings. CI - (c) 2026. Children's Hospital, Zhejiang University School of Medicine. FAU - Liu, Yun-Fei AU - Liu YF AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Wang, You-Xin AU - Wang YX AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Li, Li AU - Li L AD - Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, China. FAU - Shi, Di AU - Shi D AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Wolters, Maike AU - Wolters M AD - Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Zhang, Ping-Ping AU - Zhang PP AD - Ningbo Center for Healthy Lifestyle Research, The First Affiliated Hospital of Ningbo University, Ningbo, China. FAU - Dang, Jia-Jia AU - Dang JJ AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Cai, Shan AU - Cai S AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Huang, Tian-Yu AU - Huang TY AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Wang, Ya-Qi AU - Wang YQ AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Liu, Jie-Yu AU - Liu JY AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Wang, Ming-Yue AU - Wang MY AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Wu, Yu-Ying AU - Wu YY AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Nur, Enkar AU - Nur E AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Lian, Wen-Jia AU - Lian WJ AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Guo, Li-Po AU - Guo LP AD - Changping Health Education Center for Primary and Secondary Schools, Beijing, China. FAU - Li, Yuan-Yuan AU - Li YY AD - Changping Health Education Center for Primary and Secondary Schools, Beijing, China. FAU - Song, Jie-Yun AU - Song JY AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Li, Jing AU - Li J AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Dong, Yan-Hui AU - Dong YH AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Cui, Yan-Chun AU - Cui YC AD - Beijing Children's Hospital, Capital Medical University, Beijing, China. FAU - Hebestreit, Antje AU - Hebestreit A AD - Department of Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Yeo, Yee Hui AU - Yeo YH AD - Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, USA. FAU - Sawyer, Susan M AU - Sawyer SM AD - Department of Paediatrics, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, VIC, Australia. AD - Murdoch Children's Research Institute, Parkville, VIC, Australia. AD - Centre for Adolescent Health, Royal Children's Hospital, Parkville, VIC, Australia. FAU - Wang, Hui AU - Wang H AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. huiwang@bjmu.edu.cn. FAU - Song, Yi AU - Song Y AUID- ORCID: 0000-0001-6990-6781 AD - Institute of Child and Adolescent Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. songyi@bjmu.edu.cn. LA - eng GR - 2022-1G-4251/Capital's Funds for Health Improvement and Research/ GR - 82273654/National Natural Science Foundation of China/ GR - LTGY24H260007/Zhejiang Provincial Natural Science Foundation of China/ GR - 2025KY1315/Medical Health Science and Technology Project of Zhejiang Province/ GR - 2022-B126/Cyrus Tang Foundation for Young Scholar 2022/ GR - 202406010179/China Scholarship Council/ GR - 202406010169/China Scholarship Council/ PT - Journal Article DEP - 20260828 PL - Switzerland TA - World J Pediatr JT - World journal of pediatrics : WJP JID - 101278599 SB - IM MH - Humans MH - Child MH - Female MH - *Waist-Height Ratio MH - Male MH - Genetic Predisposition to Disease MH - Adolescent MH - *Fatty Liver/diagnosis/genetics/epidemiology MH - Polymorphism, Single Nucleotide MH - China MH - Mass Screening/methods MH - Genetic Risk Score MH - Nutrition Surveys OTO - NOTNLM OT - Genetic variants OT - Metabolic dysfunction-associated steatotic liver disease OT - Pediatric OT - Screening OT - Waist-to-height ratio COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: The Beijing study and Ningbo study received approval from the Ethics Committee of Review Board of Peking University Health Science Center (Approval No. 00001052-22018) and the Ethics Committee of Ningbo First Hospital (Approval No. 2021-R168), respectively. Written informed consent was obtained from the children and their parents prior to enrollment. Analyses based on the GBD, 1000G Project, and NHANES datasets used publicly available de-identified data and therefore did not require additional ethical approval. The authors confirm that they are accountable for all aspects of the work including full data access, data integrity, and accuracy of data analysis. EDAT- 2026/08/28 18:06 MHDA- 2026/09/15 18:07 CRDT- 2026/08/28 11:27 PHST- 2025/12/23 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/03/11 00:00 [revised] PHST- 2026/09/15 18:07 [medline] PHST- 2026/08/28 18:06 [pubmed] PHST- 2026/08/28 11:27 [entrez] AID - 10.1007/s12519-026-01084-9 [pii] AID - 10.1007/s12519-026-01084-9 [doi] PST - ppublish SO - World J Pediatr. 2026 Jul;22(7):805-818. doi: 10.1007/s12519-026-01084-9. Epub 2026 Aug 28. PMID- 42663583 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20261029 IS - 2219-6749 (Electronic) IS - 0258-414X (Print) IS - 0258-414X (Linking) VI - 44 IP - 2 DP - 2026 Aug 27 TI - Is the cervical bone a biological marker for bone age assessment? PG - 57-66 LID - 10.5281/zenodo.21849300 [doi] AB - Age assessment is essential in forensic practice when the chronological age of living individuals is unknown, particularly in legal, civil, migration, and asylum contexts requiring the judicial determination of age-related rights and responsibilities. This study aimed to evaluate the performance of two cervical vertebral methods in a Portuguese reference subadult population (6-23 years), ethnically homogeneous, using the analysis of the fourth cervical vertebra (C4) on lateral cephalometric radiographs. Two approaches were applied: Baccetti's qualitative morphological staging of C2-C4 and Cameriere's morphometric ratio of C4. A total of 528 lateral cephalometric radiographs, balanced by age and sex, were analysed independently by trained observers. Intra- and inter-observer reliability were evaluated using Intraclass Correlation Coefficient (ICC) and weighted Cohen's kappa (kappa). Statistical procedures included correlation analyses, multiple linear regression, Classification Trees (CT), and Receiver Operating Characteristic (ROC) curves to assess performance at legally relevant thresholds (12, 14, 16, 18 years). Baccetti's method explained 75.3% (coefficient of determination R(2)=0.753) of chronological age variability, with a mean error of approximately two years and high accuracy for thresholds of 12-16 years. Cameriere's ratio showed lower explanatory capacity (R(2)=0.568) and a mean error of 2.7 years, although its ROC curves demonstrated good discriminatory performance across all age cut-offs. The combination of both methods showed a slight increase in predictive performance (R(2)=0.784), although this combined approach was not formally evaluated as an independent model. Females reached skeletal maturity earlier, although error rates were similar between sexes. Reliability was excellent across methods. Both approaches proved applicable for forensic age assessment, offering complementary advantages: Baccetti's method provides broader morphological interpretation, whereas Cameriere's morphometric ratio offers objectivity and reproducibility. These population-specific reference data support the forensic use of cervical vertebral analysis as part of a multimodal age estimation framework. CI - Copyright(c) 2026 IOFOS This work is published and licensed by International Organization for Forensic Odonto-Stomatology. FAU - Pereira, Cristiana Palmela AU - Pereira CP AUID- ORCID: 0000-0002-9164-7189 AD - School of Dental Medicine University of Lisbon. FAU - Bonvini, Rebeca AU - Bonvini R AD - Department of Earth, Environmental and Life Sciences, University of Genoa, Italy. FAU - Santos, Rui AU - Santos R AUID- ORCID: 0000-0002-7371-363X AD - School of Technology and Management, Polytechnic University of Leiria. FAU - Vanin, Stefano AU - Vanin S AUID- ORCID: 0000-0003-1676-5916 AD - Department of Earth, Environmental and Life Sciences, University of Genoa, Italy. FAU - Cameriere, Roberto AU - Cameriere R AUID- ORCID: 0000-0002-3775-2244 AD - Department of Medicine and Health Science "Vincenzo Tiberio", University of Molise, Age Estimation Project, Campobasso, Italy. LA - eng PT - Journal Article DEP - 20260827 PL - Australia TA - J Forensic Odontostomatol JT - The Journal of forensic odonto-stomatology JID - 8501421 SB - IM MH - Humans MH - *Age Determination by Skeleton/methods MH - *Cervical Vertebrae/diagnostic imaging/growth & development/anatomy & histology MH - Female MH - Child MH - Adolescent MH - Cephalometry MH - Male MH - Young Adult MH - Reproducibility of Results MH - Portugal PMC - PMC13713070 OTO - NOTNLM OT - Baccetti's morphological staging system OT - Bone Age Assessment OT - Cameriere's morphometric method OT - Cephalometric OT - Cervical Vertebrae COIS- The authors report no conflicts of interest in this work. EDAT- 2026/08/28 11:49 MHDA- 2026/08/28 11:50 PMCR- 2026/12/15 CRDT- 2026/08/28 10:23 PHST- 2026/08/28 11:50 [medline] PHST- 2026/08/28 11:49 [pubmed] PHST- 2026/08/28 10:23 [entrez] PHST- 2026/12/15 00:00 [pmc-release] AID - JFOS-44-2-57 [pii] AID - 10.5281/zenodo.21849300 [doi] PST - epublish SO - J Forensic Odontostomatol. 2026 Aug 27;44(2):57-66. doi: 10.5281/zenodo.21849300. PMID- 42663578 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20261009 IS - 2219-6749 (Electronic) IS - 0258-414X (Print) IS - 0258-414X (Linking) VI - 44 IP - 2 DP - 2026 Aug 27 TI - Sexual dimorphism based on metric and non-metric parameters of human teeth in a Brazilian population. PG - 2-15 LID - 10.5281/zenodo.21848953 [doi] AB - In forensic contexts, incomplete or fragmented bones are frequently encountered due to post-mortem damage and taphonomic changes, and teeth can be considered a valid and reliable source for sex estimation, as they are among the most resistant structures of the human body. Methods based on metric and non-metric dental traits are commonly used for sex estimation. The aim of this study was to evaluate the presence of sexual dimorphism in a Brazilian population through metric and non-metric analysis of teeth. A total of 73 individuals aged between 18 and 25 years were evaluated. All analyses were conducted on the upper jaw. The metric analysis consisted of obtaining buccolingual and mesiodistal measurements of the clinical crown of the teeth. In addition to measurements for each tooth, the maxillary dental arch perimeter and intercanine distance were also considered. The non-metric analysis consisted of observing and describing traits present or absent in the teeth, using the ASUDAS. Intraobserver error was assessed using the paired t-test and the Dahlberg method. Parametric or non-parametric tests were applied according to the data distribution. The mesiodistal and buccolingual dimensions proved effective for identifying sex differences, except for teeth 12/22 (mesiodistal) and 13/23 (buccolingual). The maxillary dental arch perimeter and intercanine distance were significantly larger in males. Regarding non-metric traits, the results were less significant; only a few teeth presented traits associated with sexual dimorphism: the lingual tubercle (tooth 22), the mesial marginal ridge tubercle (tooth 26), and the hypocone cusp (teeth 17 and 27). It is concluded that the findings, although relevant, should be interpreted with caution, as their consistency still needs to be confirmed. Therefore, additional studies with larger samples from different regions of Brazil are necessary to validate these parameters and consider them reliable in anthropological and forensic contexts. CI - Copyright(c) 2026 IOFOS This work is published and licensed by International Organization for Forensic Odonto-Stomatology. FAU - Costa Rossi Junior, Wagner AU - Costa Rossi Junior W AUID- ORCID: 0000-0002-9889-414X AD - Department of Anatomy, Institute of Biomedical Sciences, Federal University of Alfenas (UNIFAL), Alfenas, MG, Brazil. FAU - Esteves, Alessandra AU - Esteves A AD - Department of Anatomy, Institute of Biomedical Sciences, Federal University of Alfenas (UNIFAL), Alfenas, MG, Brazil. FAU - Alves Nogueira, Denismar AU - Alves Nogueira D AD - Department of Statistics, Institute of Exact Sciences, Federal University of Alfenas (UNIFAL), Alfenas, MG, Brazil. FAU - Silva Pereira, Bruna AU - Silva Pereira B AD - School of Dentistry, Federal University of Alfenas (UNIFAL), Alfenas, MG, Brazil. FAU - Chiomark Malaquias, Lara Kramer AU - Chiomark Malaquias LK AD - School of Dentistry, Federal University of Alfenas (UNIFAL), Alfenas, MG, Brazil. FAU - de Araujo Oliveira, Clarice AU - de Araujo Oliveira C AUID- ORCID: 0009-0009-9562-1427 AD - Department of Pathology and Legal Medicine, School of Medicine of Ribeirao Preto (FMRP), University of Sao Paulo (USP), Ribeirao Preto, SP, Brazil. FAU - Alves da Silva, Ricardo Henrique AU - Alves da Silva RH AUID- ORCID: 0000-0002-1532-1670 AD - Department of Stomatology, Public Health and Forensic Odontology, Ribeirao Preto School of Dentistry (FORP), University of Sao Paulo (USP), Ribeirao Preto, SP, Brazil. LA - eng PT - Journal Article DEP - 20260827 PL - Australia TA - J Forensic Odontostomatol JT - The Journal of forensic odonto-stomatology JID - 8501421 SB - IM MH - Humans MH - Female MH - Brazil MH - Adolescent MH - Male MH - Young Adult MH - Adult MH - *Sex Characteristics MH - Forensic Dentistry MH - *Tooth/anatomy & histology MH - *Odontometry MH - Tooth Crown/anatomy & histology PMC - PMC13645323 OTO - NOTNLM OT - Dentition OT - Forensic Anthropology OT - Forensic Dentistry OT - Permanent OT - Sex Characteristics OT - Sex Determination Analysis OT - Tooth COIS- The authors report no conflicts of interest in this work. EDAT- 2026/08/28 11:49 MHDA- 2026/08/28 11:50 PMCR- 2026/12/15 CRDT- 2026/08/28 10:23 PHST- 2026/08/28 11:50 [medline] PHST- 2026/08/28 11:49 [pubmed] PHST- 2026/08/28 10:23 [entrez] PHST- 2026/12/15 00:00 [pmc-release] AID - JFOS-44-2-02 [pii] AID - 10.5281/zenodo.21848953 [doi] PST - epublish SO - J Forensic Odontostomatol. 2026 Aug 27;44(2):2-15. doi: 10.5281/zenodo.21848953. PMID- 42663493 OWN - NLM STAT- Publisher LR - 20260828 IS - 1941-2452 (Electronic) IS - 0884-5336 (Linking) DP - 2026 Aug 28 TI - Seeing is believing: The evolving role of muscle ultrasound in comprehensive nutritional care of pediatric oncology patients-A case series. LID - 10.1002/ncp.70177 [doi] AB - Traditional nutritional assessments in pediatric oncology, such as weight and body mass index, often fail to accurately capture changes in body composition, frequently masking significant muscle depletion, or secondary sarcopenia. This retrospective case series evaluates the novel clinical application of muscle ultrasound (mUS) by a pediatric oncology dietitian to help objectively guide and monitor nutrition interventions. We report our observations regarding three pediatric patients with cancer (one school-aged child and two adolescents/young adults). Serial mUS measurements of the quadriceps femoris and rectus femoris were obtained alongside standard anthropometric data. Nutritional interventions, including appetite stimulants and enteral nutrition, were tailored based on these combined assessments. In all three cases, mUS findings were discordant with total body weight trends. One patient exhibited weight gain on appetite stimulants, but mUS revealed concurrent muscle loss, prompting a transition to enteral nutrition. Conversely, another patient experienced persistent weight loss, but mUS confirmed muscle preservation and growth and led to reduced healthcare utilization. These observations suggest mUS is a feasible, non-invasive tool with potential to complement conventional anthropometric measures by detecting subclinical muscle changes that may otherwise be missed. Given the small, heterogeneous sample and retrospective design, these findings should be considered as hypothesis-generating rather than conclusive and warrant further validation in larger, prospective studies before mUS can be recommended as a standard component of nutritional assessment in pediatric oncology. CI - (c) 2026 American Society for Parenteral and Enteral Nutrition. FAU - Hawes, Corey AU - Hawes C AUID- ORCID: 0000-0002-3444-0923 AD - Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA. FAU - Radulescu, Vlad Calin AU - Radulescu VC AD - Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA. FAU - Munnikhuysen, Senna AU - Munnikhuysen S AD - Department of Pediatrics, University of Kentucky, Lexington, Kentucky, USA. LA - eng PT - Journal Article DEP - 20260828 PL - United States TA - Nutr Clin Pract JT - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JID - 8606733 SB - IM OTO - NOTNLM OT - body composition OT - muscle ultrasound OT - pediatric oncology OT - secondary sarcopenia EDAT- 2026/08/28 11:49 MHDA- 2026/08/28 11:49 CRDT- 2026/08/28 09:23 PHST- 2026/08/03 00:00 [revised] PHST- 2026/02/12 00:00 [received] PHST- 2026/08/07 00:00 [accepted] PHST- 2026/08/28 11:49 [medline] PHST- 2026/08/28 11:49 [pubmed] PHST- 2026/08/28 09:23 [entrez] AID - 10.1002/ncp.70177 [doi] PST - aheadofprint SO - Nutr Clin Pract. 2026 Aug 28. doi: 10.1002/ncp.70177. PMID- 42663129 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260903 IS - 1613-9860 (Electronic) IS - 1869-6716 (Print) IS - 1613-9860 (Linking) VI - 16 IP - 1 DP - 2026 Jan 7 TI - Documenting two decades of longitudinal changes to a community-engaged obesity prevention intervention for Native American families to facilitate scale-up. LID - 10.1093/tbm/ibag056 [doi] LID - ibag056 AB - BACKGROUND: Community-based participatory research (CBPR) interventions frequently undergo adaptation as they move from efficacy studies to dissemination; yet long-term adaptations are rarely documented in ways that support replication or scale-up. PURPOSE: To demonstrate a structured approach for retrospectively documenting longitudinal adaptations to Healthy Children, Strong Families (HCSF)-a culturally grounded, evidence-based obesity prevention intervention for Native American families-as it evolved into Turtle Island Tales. METHODS: We conducted a retrospective review of permanent records generated between 2006 and 2026 spanning three major program iterations: HCSF1, HCSF2, and Turtle Island Tales. Guided by the Framework for Reporting Adaptations and Modifications to Evidence-based Interventions (FRAME), the implementation-strategy extension FRAME-IS, and the Adaptome, adaptations were categorized as changes to intervention governance, content, structure, or strategy. Data sources included intervention materials, study protocols, quantitative and qualitative trial data, meeting minutes, and emails. RESULTS: Adaptations were layered and interdependent and were documented as preserving core functions while supporting intended implementation outcomes (e.g. acceptability, feasibility, reach, adoption, sustainability). Governance adaptations reflected shifts from more centralized, CBPR-grounded adaptation and implementation processes to greater local decision-making by community implementers. Content adaptations included greater integration of traditional knowledge and new lessons addressing sleep, emotional regulation, and family traditions. Structural adaptations involved delivery changes aligned with community systems and development of culturally resonant branding and characters. Strategy adaptations included opt-out classroom-based recruitment, embedding implementation within existing community roles, and revised training materials. CONCLUSIONS: Organizing adaptations into governance, content, structure, and strategy provides a pragmatic approach for documenting flexibility across long-term CBPR partnerships and may offer considerations for documentation of intervention adaptations in similar settings. CLINICAL TRIAL INFORMATION: The Clinical Trials Registrations #NCT01776255, NCT06298149. CI - (c) Society of Behavioral Medicine 2026. FAU - Tomayko, Emily J AU - Tomayko EJ AUID- ORCID: 0000-0002-9074-0875 AD - Department of Food Systems, Nutrition, and Kinesiology, Montana State University, Bozeman, MT, United States. AD - Center for American Indian and Rural Health Excellence, Montana State University, Bozeman, MT, United States. FAU - Estabrooks, Paul A AU - Estabrooks PA AUID- ORCID: 0000-0003-2261-9886 AD - Department of Health and Kinesiology, College of Health, University of Utah, Salt Lake City, UT, United States. FAU - Warne, Teresa M AU - Warne TM AD - Center for American Indian and Rural Health Excellence, Montana State University, Bozeman, MT, United States. FAU - Merle, James L AU - Merle JL AUID- ORCID: 0000-0001-9646-2733 AD - Department of Population Health Sciences, School of Medicine, University of Utah, Salt Lake City, UT, United States. FAU - Adams, Alexandra K AU - Adams AK AD - Center for American Indian and Rural Health Excellence, Montana State University, Bozeman, MT, United States. LA - eng SI - ClinicalTrials.gov/NCT01776255 SI - ClinicalTrials.gov/NCT06298149 GR - U54 CA280812/CA/NCI NIH HHS/United States GR - 5U54CA280812/National Cancer Institute of the National Institute of Health/ PT - Journal Article PL - England TA - Transl Behav Med JT - Translational behavioral medicine JID - 101554668 SB - IM MH - Humans MH - Community-Based Participatory Research MH - Retrospective Studies MH - Child MH - Female MH - *Indians, North American MH - *Health Promotion/methods MH - *Pediatric Obesity/prevention & control MH - Longitudinal Studies MH - *Obesity/prevention & control MH - *American Indian or Alaska Native MH - Male MH - Family PMC - PMC13522849 OAB - Health promotion interventions that demonstrate effectiveness in research settings often require refinement as they are used across different communities and delivery contexts, particularly when the intervention does not fully align with local needs, cultures, or systems. This article examines how a family-based wellness program developed in partnership with multiple Native American communities changed over two decades as it moved from research trials into broader community use. Originally developed as Healthy Children, Strong Families and later renamed Turtle Island Tales, the program underwent adaptations to strengthen cultural relevance, improve feasibility, and support sustained use. Over time, local community partners adjusted how the program was delivered, how families were invited to participate, and how materials reflected culture and community values. These changes included integrating cultural teachings and storytelling, shifting from mailed home delivery to school- and community-based delivery, and aligning implementation with existing community roles and systems. Throughout this process, the program's focus on family health promotion was intentionally maintained. By documenting a way to categorize adaptations across longer-term stages of program development, this article provides guidance for educators, community organizations, and researchers on how programs can be adapted across settings while maintaining the elements necessary to achieve intended outcomes. OABL- eng OTO - NOTNLM OT - American Indian/Alaska Native OT - health behavior OT - health promotion OT - implementation science OT - pediatric obesity OT - program evaluation COIS- All authors declare that they have no conflicts of interest. EDAT- 2026/08/28 11:49 MHDA- 2026/08/28 11:50 PMCR- 2026/08/28 CRDT- 2026/08/28 06:43 PHST- 2026/08/28 11:50 [medline] PHST- 2026/08/28 11:49 [pubmed] PHST- 2026/08/28 06:43 [entrez] PHST- 2026/08/28 00:00 [pmc-release] AID - 8772273 [pii] AID - ibag056 [pii] AID - 10.1093/tbm/ibag056 [doi] PST - ppublish SO - Transl Behav Med. 2026 Jan 7;16(1):ibag056. doi: 10.1093/tbm/ibag056. PMID- 42662625 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260829 IS - 1937-8688 (Electronic) VI - 53 DP - 2026 TI - Association of oxidative stress, inflammation, and ADIPOQ gene expression in young adults at risk of non-alcoholic fatty liver disease and cardiovascular disease. PG - 175 LID - 10.11604/pamj.2026.53.175.47681 [doi] LID - 175 AB - INTRODUCTION: non-alcoholic fatty liver disease (NAFLD) and cardiovascular diseases (CVD) are increasingly seen in young adults due to obesity, sedentary lifestyle, and poor diet. Oxidative stress and chronic inflammation are key contributors to their development, promoting liver damage, endothelial dysfunction, and atherosclerosis. Adiponectin, encoded by the ADIPOQ gene, has protective metabolic effects, and its reduction, often influenced by genetic factors, is linked to increased disease risk. This study evaluates the relationship between oxidative stress (MDA), inflammation (IL-6), and ADIPOQ gene expression in young adults to identify early biomarkers. METHODS: this case-control study (2022 December-2024 December) included 300 participants aged 18-45 years with clinically established non-alcoholic fatty liver and/or cardiovascular risk disease, who were categorized as the case group. The remaining 150 healthy individuals served as the control group. MDA and IL-6 levels were measured using ELISA, while ADIPOQ expression was analyzed via reverse transcription polymerase chain reaction (RT-PCR). Data were analyzed using t-tests, receiver operating characteristic (ROC) analysis, and quantile regression in Stata 17.0, with significance set at p<0.05. RESULTS: cases showed elevated MDA and IL-6 levels and reduced ADIPOQ expression compared to controls. ROC analysis identified MDA as the strongest biomarker (AUC = 0.9605). IL-6 showed diagnostic potential but lost significance after adjustment for sociodemographic variables. MDA and IL-6 levels negatively correlated with ADIPOQ expression. CONCLUSION: oxidative stress and inflammation are associated with reduced ADIPOQ expression in young adults at risk of NAFLD and CVD. While ADIPOQ alone may have limited predictive power, early identification of oxidative and inflammatory markers could aid in timely intervention. CI - Copyright: Rachana Raveendran et al. FAU - Raveendran, Rachana AU - Raveendran R AD - Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Josephine, Anthony AU - Josephine A AD - Department of Research, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Sureka, Varalakshmi AU - Sureka V AD - Department of Research, Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Kalaiselvi, Periandavan AU - Kalaiselvi P AD - Department of Medical Biochemistry, Dr. A.L.M. PG Institute of Basic Medical Sciences, University of Madras, Tamil Nadu, India. FAU - Varma, Poornima Raja Raja AU - Varma PRR AD - Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Kandy, Lasitha Neroth AU - Kandy LN AD - Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Nair, Renjith Kariyil Radhakrishnan AU - Nair RKR AD - Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Kottola, Manjusha AU - Kottola M AD - Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Mohanan, Midhun Thazhissery AU - Mohanan MT AD - Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Thoduvayil, Swathi AU - Thoduvayil S AD - Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Abdulla, Thahira AU - Abdulla T AD - Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Kottiyath, Pinchulatha AU - Kottiyath P AD - Meenakshi Academy of Higher Education and Research (Deemed to be University), Chennai, Tamil Nadu, India. FAU - Divakaran, Dinesh Roy AU - Divakaran DR AD - Genetika, Centre for Advanced Genetic Studies, Thiruvananthapuram, Kerala, India. LA - eng PT - Journal Article DEP - 20260427 PL - Uganda TA - Pan Afr Med J JT - The Pan African medical journal JID - 101517926 RN - 0 (Adiponectin) RN - 0 (ADIPOQ protein, human) RN - 0 (Biomarkers) RN - 0 (Interleukin-6) RN - 4Y8F71G49Q (Malondialdehyde) RN - 0 (IL6 protein, human) SB - IM MH - Humans MH - *Adiponectin/genetics MH - *Oxidative Stress/physiology MH - *Non-alcoholic Fatty Liver Disease/genetics/epidemiology MH - Female MH - Male MH - Adult MH - Case-Control Studies MH - Young Adult MH - *Inflammation/epidemiology MH - *Cardiovascular Diseases/epidemiology/genetics MH - Adolescent MH - Biomarkers/metabolism MH - Interleukin-6/metabolism/blood MH - Middle Aged MH - Gene Expression MH - Enzyme-Linked Immunosorbent Assay MH - Malondialdehyde/metabolism MH - ROC Curve PMC - PMC13521425 OTO - NOTNLM OT - ADIPOQ gene expression OT - cardiovascular disease OT - inflammatory markers OT - non-alcoholic fatty liver disease OT - oxidative stress COIS- The authors declare no competing interests. EDAT- 2026/08/28 11:50 MHDA- 2026/08/28 11:51 PMCR- 2026/04/27 CRDT- 2026/08/28 06:13 PHST- 2025/04/21 00:00 [received] PHST- 2025/06/03 00:00 [accepted] PHST- 2026/08/28 11:51 [medline] PHST- 2026/08/28 11:50 [pubmed] PHST- 2026/08/28 06:13 [entrez] PHST- 2026/04/27 00:00 [pmc-release] AID - PAMJ-53-175 [pii] AID - 10.11604/pamj.2026.53.175.47681 [doi] PST - epublish SO - Pan Afr Med J. 2026 Apr 27;53:175. doi: 10.11604/pamj.2026.53.175.47681. eCollection 2026. PMID- 42662191 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260828 LR - 20260829 IS - 2633-0040 (Electronic) IS - 2633-0040 (Linking) VI - 7 DP - 2026 Jan-Dec TI - Interim analysis of an international multi-site prospective natural history study evaluating the clinical presentation and progression of Leigh syndrome spectrum disorders. PG - 26330040261476231 LID - 10.1177/26330040261476231 [doi] LID - 26330040261476231 AB - BACKGROUND: Leigh Syndrome Spectrum (LSS) is the most common pediatric mitochondrial disease syndromic presentation. However, its natural history has not been well-characterized, particularly across diverse populations. OBJECTIVES: Information obtained through robust, prospective natural history studies (NHSs) in LSS will be foundational to accurately counsel newly diagnosed families, develop effective therapeutics, and identify outcome measures for future clinical trials. DESIGN: We describe an ongoing multi-site, international, patient advocacy group funded, observational NHS in LSS. We employed a multi-site international federated design with local regulatory review coupled with central regulatory and coordinator support. To date, NHS outcome measures have been collected on LSS participants across 5 sites every 3 to 6 months for up to 3.8 years. METHODS: Objective and subjective outcome measures were carefully selected by the international LSS outcome measure working group. Study data across sites were anonymized and combined for cleaning and analysis at the Data Coordinating Center (Children's Hospital of Philadelphia). Descriptive statistics of the study cohort and inter-measure correlations were analyzed across NHS assessments. RESULTS: Preliminary analysis of the first 74 participants was completed to characterize demographics, symptomatology, and clinical history. The average age at enrollment was 10.7 years, ranging from 0 to 50 years. The most common gene disorders were MT-ATP6 (22%, n=16), MT-ND5 (8%, n=6) and SURF1 (8%, n=6). No statistically significant between-group differences were detected by sex or genetic etiology. High inter-measure correlation between all the outcome measures and "gold standard" outcomes provides justification for future use of these assessments in both NHSs and clinical trials. CONCLUSION: We have demonstrated the feasibility of prospectively collecting robust international-site LSS NHS data through multi-site collaboration. These LSS community data will be critical for informing therapeutic development, outcome measure selection and clinical trial design, and providing baseline comparator evidence for development of future therapeutic interventions. CI - (c) The Author(s) 2026. FAU - MacMullen, Laura E AU - MacMullen LE AUID- ORCID: 0000-0003-2458-6889 AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia,Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Stanley, Katelynn D AU - Stanley KD AUID- ORCID: 0009-0008-0042-5435 AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia,Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Christodoulou, John AU - Christodoulou J AD - Brain and Mitochondrial Research Group, Murdoch Children's Research Institute, Melbourne, VIC, Australia. RINGGOLD: 34361 AD - Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia. FAU - Cohen, Bruce H AU - Cohen BH AUID- ORCID: 0000-0003-2253-8955 AD - Rebecca D. Considine Research Institute, Akron Children's Hospital, Akron, OH, USA. RINGGOLD: 1079 AD - Department of Pediatrics, Akron Children's Hospital, Akron, OH, USA. RINGGOLD: 1079 FAU - Demczko, Matthew AU - Demczko M AUID- ORCID: 0000-0003-0232-9611 AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia,Philadelphia, PA, USA. RINGGOLD: 6567 AD - Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Goldstein, Amy C AU - Goldstein AC AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia,Philadelphia, PA, USA. RINGGOLD: 6567 AD - Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Haas, Richard AU - Haas R AD - Department of Pediatrics, University of California, San Diego, CA, USA. AD - The Department of Neurosciences, University of California San Diego. RINGGOLD: 8784 AD - Rady Children's Hospital, UC San Diego School of Medicine, La Jolla, CA, USA. FAU - Koenig, Mary Kay AU - Koenig MK AD - Department of Pediatrics, Division of Child and Adolescent Neurology, McGovern Medical School at UTHealth Houston, Houston, TX, USA. FAU - Poblete, Maria AU - Poblete M AD - Department of Pediatrics, Division of Child and Adolescent Neurology, McGovern Medical School at UTHealth Houston, Houston, TX, USA. FAU - Rice, Alyssa AU - Rice A AD - Department of Pediatrics, Division of Child and Adolescent Neurology, McGovern Medical School at UTHealth Houston, Houston, TX, USA. FAU - Rossman, Ian AU - Rossman I AD - Rebecca D. Considine Research Institute, Akron Children's Hospital, Akron, OH, USA. RINGGOLD: 1079 FAU - Ruiz, Carolina AU - Ruiz C AD - The Department of Neurosciences, University of California San Diego. RINGGOLD: 8784 AD - Rady Children's Hospital, UC San Diego School of Medicine, La Jolla, CA, USA. FAU - Russo, S Nicholas AU - Russo SN AUID- ORCID: 0000-0001-5045-9301 AD - Department of Pediatrics, Division of Child and Adolescent Neurology, McGovern Medical School at UTHealth Houston, Houston, TX, USA. FAU - Thorburn, David R AU - Thorburn DR AD - Brain and Mitochondrial Research Group, Murdoch Children's Research Institute, Melbourne, VIC, Australia. RINGGOLD: 34361 AD - Department of Paediatrics, University of Melbourne, Melbourne, VIC, Australia. FAU - Uebergang, Eloise AU - Uebergang E AUID- ORCID: 0000-0003-0305-7822 AD - Brain and Mitochondrial Research Group, Murdoch Children's Research Institute, Melbourne, VIC, Australia. RINGGOLD: 34361 FAU - Yang, Jennifer H AU - Yang JH AUID- ORCID: 0000-0001-5438-7210 AD - The Department of Neurosciences, University of California San Diego. RINGGOLD: 8784 AD - Rady Children's Hospital, UC San Diego School of Medicine, La Jolla, CA, USA. FAU - Zolkipli-Cunningham, Zarazuela AU - Zolkipli-Cunningham Z AUID- ORCID: 0000-0002-0743-8879 AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia,Philadelphia, PA, USA. RINGGOLD: 6567 AD - Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. FAU - Falk, Marni J AU - Falk MJ AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia,Philadelphia, PA, USA. RINGGOLD: 6567 AD - Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. CN - Leigh Syndrome Roadmap Project Natural History Study Consortium LA - eng PT - Journal Article DEP - 20260826 PL - England TA - Ther Adv Rare Dis JT - Therapeutic advances in rare disease JID - 9918557474706676 PMC - PMC13519198 OAB - WHY WAS THE STUDY DONE? Leigh Syndrome Spectrum (LSS) Disorders are the most common type of pediatric mitochondrial disease. Potentially affecting both children and adults, LSS manifest with stroke-like brain lesions, muscle dysfunction, exercise intolerance, impaired cognitive development or function, and sometimes early death. Through controlled studies in diverse populations over long periods of time, researchers can gather information necessary to better counsel patients and families about disease symptoms and outcomes and design improved clinical trials. WHAT DID THE RESEARCHERS DO? Patient advocacy groups and academic medicine centers from around the world collaborated to design a natural history study that follows patients with LSS at multiple sites for up to five years. We gathered experts to determine a comprehensive set of administered tests and patient/family surveys that would most accurately capture the symptoms and downstream effects of living with LSS. We compiled preliminary data from the first five data collection sites to describe the characteristics of the participants. WHAT DID THE RESEARCHERS FIND? Data from the first 74 participants was summarized to understand the characteristics of the group and the most common symptoms. No symptomatic differences were found by patient sex or genetic subtype. High inter-measure correlation between all of the studied outcome measures with "gold standard" outcome measures validated that the studied assessments test what they were intended to evaluate and that they may ultimately be useful assessments in future observational and treatment studies in LSS patients. WHAT DO THE FINDINGS MEAN? This work demonstrates the feasibility of collecting high quality, useful data across many different medical sites across the world and using that data to better understand LSS. These findings may help clinicians most accurately counsel and care, design better clinical trials, and serve as supporting data during the drug development and review process of future candidate therapies. OABL- eng OTO - NOTNLM OT - Leigh syndrome spectrum OT - mitochondrial disease OT - natural history OT - neurodegenerative disease COIS- The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: JC and DRT serve on the board of directors and are members of its Scientific and Medical Advisory Panel for the Mito Foundation, which funds the Australian node of the NHS, and is on the SMAP of the Childhood Dementia Initiative. Unrelated to this work, JY receives research funding from the National Institute of Health and Pediatric Epilepsy Research Foundation. She has received speaker fees from UCB. ACG serves on the advisory board of UCB. ZZ serves on the Scientific and Medical Advisory Board of the United Mitochondrial Disease Foundation. MJF serves on the UMDF Scientific and Medical Advisory Board, and is an invited editorial member of this journal (although has not reviewed any articles for this journal to date). EDAT- 2026/08/28 11:49 MHDA- 2026/08/28 11:50 PMCR- 2026/08/26 CRDT- 2026/08/28 05:46 PHST- 2025/11/19 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/08/28 11:50 [medline] PHST- 2026/08/28 11:49 [pubmed] PHST- 2026/08/28 05:46 [entrez] PHST- 2026/08/26 00:00 [pmc-release] AID - 10.1177_26330040261476231 [pii] AID - 10.1177/26330040261476231 [doi] PST - epublish SO - Ther Adv Rare Dis. 2026 Aug 26;7:26330040261476231. doi: 10.1177/26330040261476231. eCollection 2026 Jan-Dec. PMID- 42661870 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260903 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Measurement tools for sedentary behavior in the Arabic-speaking countries in MENA region: a systematic review of validated instruments from the BRIDGE project. PG - 1815050 LID - 10.3389/fpubh.2026.1815050 [doi] LID - 1815050 AB - BACKGROUND: Sedentary behavior is an independent risk factor for adverse health outcomes. Screen time represents a specific domain of sedentary behavior and is often used as a proxy. Accurate measurement of these behaviors is essential for surveillance, research, and intervention. However, the availability, characteristics, and psychometric quality of validated instruments used to assess these behaviors in Arabic-speaking countries in the Middle East and North Africa (MENA) region have not been well documented. This systematic review aimed to identify, describe, and critically appraise the instruments used to assess sedentary behavior and/or screen time in this region. METHODS: This systematic review was conducted according to the PRISMA guidelines. Major electronic databases were searched to identify studies that reported the development, cross-cultural adaptation, or validation of instruments measuring sedentary behavior or screen time in Arabic-speaking MENA countries. Studies assessing at least one measurement property were eligible. Data on study characteristics, instruments, and psychometric properties were extracted. The methodological quality and measurement properties were evaluated using the COSMIN framework. RESULTS: Ten studies conducted in five MENA countries (Jordan, United Arab Emirates, Saudi Arabia, Morocco, and Syria) were included. Most studies relied on self-reported questionnaires originally designed to assess physical activity, with sedentary behavior measured as a secondary dimension. The most frequently evaluated instruments were the International Physical Activity Questionnaire (IPAQ), Global Physical Activity Questionnaire (GPAQ), and Global School-based Student Health Survey (GSHS). Only one instrument, the Sedentary Behavior Questionnaire (SBQ), was specifically designed to measure sedentary behavior and was validated in two countries among adults and university students. Overall, the psychometric properties were often insufficient or inconsistent, particularly for criterion validity. Evidence among children and adolescents is limited and mainly focuses on screen time, showing weak agreement with objective measures. CONCLUSION: The measurement of sedentary behavior in Arabic-speaking MENA countries relies largely on non-specific instruments with limited psychometric evidence. There is a clear need for the development and rigorous validation of culturally adapted, sedentary behavior-specific tools across age groups to support research, surveillance, and public health policies in the region. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/view/CRD420261283730, Identifier: CRD420261283730. CI - Copyright (c) 2026 Bartal, Bahra, Hussien, Aly, Abdelkarim and El Rhazi. FAU - Bartal, Fatima Zahrae AU - Bartal FZ AD - Laboratory of Epidemiology, Clinical Research, and Community Health, Faculty of Medicine, Pharmacy, and Dentistry, Sidi Mohamed Ben Abdallah University, Fez, Morocco. FAU - Bahra, Nassiba AU - Bahra N AD - Laboratory of Epidemiology, Clinical Research, and Community Health, Faculty of Medicine, Pharmacy, and Dentistry, Sidi Mohamed Ben Abdallah University, Fez, Morocco. FAU - Hussien, Fatma AU - Hussien F AD - Faculty of Sport Sciences, Capital University, Giza, Egypt. FAU - Aly, Mohamed AU - Aly M AD - Faculty of Sport Sciences, Assiut University, Assiut, Egypt. AD - Department of Sports Management, School of Business, ESLSCA University, Cairo, Egypt. FAU - Abdelkarim, Osama AU - Abdelkarim O AD - Faculty of Sport Sciences, Assiut University, Assiut, Egypt. AD - Department of Sports Management, School of Business, ESLSCA University, Cairo, Egypt. AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - El Rhazi, Karima AU - El Rhazi K AD - Laboratory of Epidemiology, Clinical Research, and Community Health, Faculty of Medicine, Pharmacy, and Dentistry, Sidi Mohamed Ben Abdallah University, Fez, Morocco. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260813 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Africa, Northern MH - Middle East MH - Middle Eastern People MH - Psychometrics MH - Reproducibility of Results MH - *Screen Time MH - *Sedentary Behavior MH - Surveys and Questionnaires/standards MH - North African People PMC - PMC13518537 OTO - NOTNLM OT - Arabic-speaking countries OT - COSMIN OT - MENA region OT - measurement instruments OT - psychometric properties OT - sedentary behavior COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/28 11:49 MHDA- 2026/08/28 11:50 PMCR- 2026/08/13 CRDT- 2026/08/28 05:23 PHST- 2026/02/21 00:00 [received] PHST- 2026/06/25 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/28 11:50 [medline] PHST- 2026/08/28 11:49 [pubmed] PHST- 2026/08/28 05:23 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1815050 [doi] PST - epublish SO - Front Public Health. 2026 Aug 13;14:1815050. doi: 10.3389/fpubh.2026.1815050. eCollection 2026. PMID- 42661784 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260828 LR - 20260829 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Feasibility, uptake, and exploratory outcomes of an individualized exercise program in pediatric oncology: a prospective single-center pilot study. PG - 1914065 LID - 10.3389/fped.2026.1914065 [doi] LID - 1914065 AB - INTRODUCTION: Exercise interventions may help mitigate treatment-related physical impairment in pediatric oncology, but implementation in routine care remains challenging, particularly during active treatment and in heterogeneous patient cohorts. PATIENTS: This prospective single-center pilot study evaluated an individualized exercise program for children and adolescents aged 4-17 years undergoing cancer treatment during the COVID-19 pandemic. METHOD: The program combined supervised in-hospital exercise, personalized home-based training, and an optional video-based SMART-Sport component introduced from month 3. The primary focus was feasibility, uptake, safety, and acceptability. Motor performance, six-minute walk distance, health-related quality of life (HRQoL), and neuropsychological functioning were assessed at baseline and six months as secondary exploratory outcomes. RESULTS: Twenty participants were enrolled; 15 completed at least one six-month follow-up assessment. Overall, 348 of 583 scheduled in-hospital exercise opportunities were attended, corresponding to a scheduled-session attendance of 59.7% using a conservative denominator. No serious program-related adverse event occurred. Movement diaries were available for 15 participants and documented 361 home-training sessions, of which 262 (72.6%) occurred during the first three months. Four participants documented use of SMART-Sport, completing 14 sessions. Exploratory complete-case analyses showed nominal within-participant improvements in hand-eye coordination, reaction time, six-minute walk distance, and selected HRQoL domains. Neuropsychological findings were inconclusive. DISCUSSION: The findings support the feasibility and safety of supervised individualized in-hospital exercise under the conditions of a specialized pediatric oncology center with a dedicated sports therapist. Feasibility was component-specific: home-training documentation decreased over time, and uptake of the optional video-based component was limited. CONCLUSION: This pilot study provides preliminary implementation data supporting further development of individualized exercise programs in pediatric oncology. Exploratory outcome findings should be interpreted as hypothesis-generating and require confirmation in larger controlled studies. CI - (c) 2026 Schuster, Loos, Traunwieser, Fruhwald and Kuhlen. FAU - Schuster, Christina AU - Schuster C AD - Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany. FAU - Loos, Elena AU - Loos E AD - Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany. FAU - Traunwieser, Thomas AU - Traunwieser T AD - Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany. FAU - Fruhwald, Michael C AU - Fruhwald MC AD - Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany. FAU - Kuhlen, Michaela AU - Kuhlen M AD - Pediatrics and Adolescent Medicine, Faculty of Medicine, University of Augsburg, Augsburg, Germany. LA - eng PT - Journal Article DEP - 20260813 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13518581 OTO - NOTNLM OT - exercise therapy OT - feasibility OT - pediatric oncology OT - physical activity OT - quality of life OT - supportive care COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/28 11:50 MHDA- 2026/08/28 11:51 PMCR- 2026/08/13 CRDT- 2026/08/28 05:16 PHST- 2026/06/19 00:00 [received] PHST- 2026/07/24 00:00 [revised] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/08/28 11:51 [medline] PHST- 2026/08/28 11:50 [pubmed] PHST- 2026/08/28 05:16 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - 10.3389/fped.2026.1914065 [doi] PST - epublish SO - Front Pediatr. 2026 Aug 13;14:1914065. doi: 10.3389/fped.2026.1914065. eCollection 2026. PMID- 42661386 OWN - NLM STAT- Publisher LR - 20260828 IS - 1467-789X (Electronic) IS - 1467-7881 (Linking) DP - 2026 Aug 27 TI - Harnessing Systems Science to Strengthen Community-Based Childhood Obesity Prevention: An Overview of the Literature. PG - e70218 LID - 10.1111/obr.70218 [doi] AB - INTRODUCTION: Addressing the obesity epidemic requires understanding the complex and multilevel dynamics that shape it. Systems science can help researchers and practitioners move beyond linear causal logic. This overview identifies empirical studies using explicit systems science methods or broader systems-informed approaches to design, implement, or evaluate community-based childhood obesity prevention efforts. We report how systems methods have been applied, their contributions to tackling obesity, challenges, and opportunities. METHODS: We searched Web of Science for English-language publications reporting empirical applications of systems thinking, systems science methods, or systems-informed ecological and participatory approaches in community-level childhood obesity prevention. Three reviewers screened 273 records, assessed full texts, and extracted data. RESULTS: Ninety-eight articles met inclusion criteria. Systems approaches were used most often during intervention design (n = 50; 51.0%), followed by implementation (n = 23; 23.5%) and evaluation (n = 14; 14.3%), with some spanning multiple stages (n = 11; 11.2%). Participatory methods such as group model building deepened understanding of structural and relational drivers, and supported context-specific adaptation and cross-sector coordination. The use of systems approaches for evaluation was limited, though emerging methods (e.g., ripple-effect mapping, longitudinal network analysis, and agent-based modeling) signal growing opportunity. Barriers included limited infrastructure for cross-sector collaboration, funding misalignment, and a lack of shared or validated metrics. CONCLUSION: Systems science has strengthened the field's ability to visualize complexity and align stakeholders in interventions' design and implementation. Its application in evaluation and scale-up remains limited. Sustained investment in participatory capacity, longitudinal infrastructure, and systems-informed implementation is needed to strengthen community-based childhood obesity prevention. CI - (c) 2026 The Author(s). Obesity Reviews published by John Wiley & Sons Ltd on behalf of World Obesity Federation. FAU - Moore, Travis R AU - Moore TR AUID- ORCID: 0000-0002-7874-0813 AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. AD - Department of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Chang Chusan, Yuilyn A AU - Chang Chusan YA AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. FAU - Calancie, Larissa AU - Calancie L AUID- ORCID: 0000-0002-8943-5590 AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. FAU - Tamvakologos, Panos I AU - Tamvakologos PI AUID- ORCID: 0009-0000-3450-7713 AD - School of Medicine, St. Georges University, University Centre, St. George's, Grenada. AD - Department of Pediatrics, Maimonides Children's Hospital, Brooklyn, New York, USA. FAU - Economos, Christina D AU - Economos CD AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, Massachusetts, USA. LA - eng PT - Journal Article PT - Review DEP - 20260827 PL - England TA - Obes Rev JT - Obesity reviews : an official journal of the International Association for the Study of Obesity JID - 100897395 SB - IM OTO - NOTNLM OT - childhood OT - community OT - obesity OT - primary care OT - systems science EDAT- 2026/08/28 11:46 MHDA- 2026/08/28 11:46 CRDT- 2026/08/28 01:43 PHST- 2026/07/20 00:00 [revised] PHST- 2026/02/10 00:00 [received] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/08/28 11:46 [medline] PHST- 2026/08/28 11:46 [pubmed] PHST- 2026/08/28 01:43 [entrez] AID - 10.1111/obr.70218 [doi] PST - aheadofprint SO - Obes Rev. 2026 Aug 27:e70218. doi: 10.1111/obr.70218. PMID- 42661054 OWN - NLM STAT- Publisher LR - 20260827 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Aug 27 TI - Sex-specific associations between pubertal development and MASLD in children: evidence from the PROC study. LID - 10.1038/s41390-026-05398-2 [doi] AB - BACKGROUND: Metabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent in children. This study aimed to determine the sex-specific association between pubertal development and risk of MASLD in children. METHODS: This longitudinal study included 1544 children aged 10-13 years from two follow-ups of a Chinese pediatric cohort (the PROC study) in Beijing. Pubertal development was assessed using Tanner staging. We employed Bayesian logistic regression to examine the cross-sectional association between pubertal development and MASLD, and employed Bayesian mixed-effects models to verify its longitudinal association. External validation was performed using National Health and Nutrition Examination Survey (NHANES) data, where puberty was defined by total testosterone in boys and estradiol in girls. RESULTS: The overall prevalence of MASLD declined with advancing pubertal stages. In boys, compared with early puberty, mid-puberty (aOR = 0.34, 95% highest density interval (HDI): 0.11-0.68) and late puberty (aOR = 0.22, 95% HDI: 0.03-0.59) showed significantly lower MASLD risk. No significant association was observed among girls. NHANES validation confirmed this protective association in boys at late puberty (aOR = 0.25, 95% HDI: 0.01-0.95), but not in girls. CONCLUSIONS: Mid-to-late puberty may significantly decrease the risk of MASLD in boys, whereas no clear association was observed in girls. IMPACT: This study reveals a sex-specific protective effect of puberty on MASLD risk in children, with advancing puberty associated with significantly lower odds of MASLD in boys, but not in girls. It adds longitudinal evidence on the puberty-MASLD association by assessing puberty via Tanner staging and conducting sex-specific analyses. The impact is to support tailoring prevention resources and health messages for MASLD by sex during puberty. CI - (c) 2026. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - He, Huiming AU - He H AD - Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Capital Medical University, Beijing, China. FAU - Guan, Mengying AU - Guan M AD - Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Capital Medical University, Beijing, China. FAU - Abudumijiti, Tuerxunayi AU - Abudumijiti T AD - Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Capital Medical University, Beijing, China. FAU - Li, Miao AU - Li M AD - Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Capital Medical University, Beijing, China. FAU - Zou, Yuchen AU - Zou Y AD - Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China. AD - Beijing Key Laboratory of Environment and Aging, Capital Medical University, Beijing, China. FAU - Vermund, Sten H AU - Vermund SH AD - College of Public Health, University of South Florida, Tampa, FL, USA. FAU - Huang, Dayong AU - Huang D AD - Department of Hematology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. hdayong@yahoo.com. FAU - Hu, Yifei AU - Hu Y AUID- ORCID: 0000-0002-4611-2206 AD - Department of Child, Adolescent Health and Maternal Care, School of Public Health, Capital Medical University, Beijing, China. huyifei@yahoo.com. AD - Beijing Key Laboratory of Environment and Aging, Capital Medical University, Beijing, China. huyifei@yahoo.com. LA - eng PT - Journal Article DEP - 20260827 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Ethics statement: Studies involving human participants were reviewed and approved by the Institutional Review Board of Capital Medical University (No.2018SY82). Written informed consent was obtained from participants' legal guardians prior to participation. For external validation, data from the NHANES were used. The NHANES is a publicly available, de-identified dataset, and all procedures were approved by the National Center for Health Statistics Ethics Review Board. Written informed consent was obtained from all participants in the NHANES. Therefore, no additional ethical approval was required for the use of the secondary data. Consent statement: Written informed consent to participate in this study was obtained from the participants' legal guardians. EDAT- 2026/08/28 11:46 MHDA- 2026/08/28 11:46 CRDT- 2026/08/27 23:55 PHST- 2026/04/06 00:00 [received] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/06/18 00:00 [revised] PHST- 2026/08/28 11:46 [medline] PHST- 2026/08/28 11:46 [pubmed] PHST- 2026/08/27 23:55 [entrez] AID - 10.1038/s41390-026-05398-2 [pii] AID - 10.1038/s41390-026-05398-2 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Aug 27. doi: 10.1038/s41390-026-05398-2. PMID- 42660934 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260830 IS - 2396-8370 (Electronic) IS - 2396-8370 (Linking) VI - 10 IP - 1 DP - 2026 Aug 7 TI - A machine learning-derived dietary pattern for aging. LID - 10.1038/s41538-026-01048-3 [doi] LID - 264 AB - Diet is a modifiable determinant of aging. We develop and validate the Machine-learning YouTHful (MYTH) Diet, a dietary pattern associated with reduced aging-related mortality. Using data from 191,689 participants in the UK Biobank, we conducted a food-wide association analysis and identified 18 food groups significantly associated with aging-related mortality. A Light Gradient Boosting Machine (LightGBM) model was used to rank food importance, leading to the construction of a 10-component MYTH Diet score (range: 0-10). Higher MYTH scores were consistently associated with reduced aging-related mortality in both internal (Quartile 4 vs. 1: hazard ratio [HR] = 0.79; 95% CI: 0.75-0.84) and external (Q4 vs. Q1: HR = 0.68; 95% CI: 0.58-0.80) validation cohorts. Multi-omics analyses revealed that the diet's protective effects were partly mediated through proteomic, metabolic, and inflammatory pathways, with mediators including TNFRSF4, the proportion of polyunsaturated fatty acids (PUFA%), and lipid-related metabolites such as medium very-low-density lipoprotein phospholipids (M-VLDL-PL). Higher MYTH scores were also linked to slower biological aging in the lungs, liver, pancreas, as well as lower risks for 15 aging-related diseases. These findings suggest that the MYTH Diet may offer a biologically informed, scalable framework for developing personalized nutrition strategies aimed at supporting healthy aging and longevity. CI - (c) 2026. The Author(s). FAU - Miao, Yating AU - Miao Y AD - Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention, Ministry of Education, China Medical University; Department of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang, China. FAU - Li, Zhirong AU - Li Z AD - Department of Social Medicine and Health Management, School of Public Health, Jilin University, Changchun, China. FAU - Zhang, Xinyao AU - Zhang X AD - Department of Social Medicine and Health Management, School of Public Health, Jilin University, Changchun, China. food@jlu.edu.cn. FAU - Liu, Zuyun AU - Liu Z AD - Department of Big Data in Health Science School of Public Health, Center for Clinical Big Data and Analytics Second Affiliated Hospital, Zhejiang Key Laboratory of Intelligent Preventive Medicine, Zhejiang University School of Medicine, Hangzhou, China. Zuyun.liu@outlook.com. FAU - Ma, Yanan AU - Ma Y AD - Key Laboratory of Environmental Stress and Chronic Disease Control & Prevention, Ministry of Education, China Medical University; Department of Biostatistics and Epidemiology, School of Public Health, China Medical University, Shenyang, China. ynma@cmu.edu.cn. AD - Health Sciences Institute, China Medical University; Liaoning Key Laboratory of Obesity and Glucose/Lipid Associated Metabolic Diseases, China Medical University, Shenyang, China. ynma@cmu.edu.cn. LA - eng GR - 72074221/National Natural Science Foundational of China/ GR - 2026-MS-190/Natural Science Foundation of Liaoning Province/ PT - Journal Article DEP - 20260807 PL - England TA - NPJ Sci Food JT - NPJ science of food JID - 101739627 PMC - PMC13522610 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/08/28 11:46 MHDA- 2026/08/28 11:47 PMCR- 2026/08/07 CRDT- 2026/08/27 23:21 PHST- 2026/04/13 00:00 [received] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/28 11:47 [medline] PHST- 2026/08/28 11:46 [pubmed] PHST- 2026/08/27 23:21 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - 10.1038/s41538-026-01048-3 [pii] AID - 1048 [pii] AID - 10.1038/s41538-026-01048-3 [doi] PST - epublish SO - NPJ Sci Food. 2026 Aug 7;10(1):264. doi: 10.1038/s41538-026-01048-3. PMID- 42660602 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260904 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 10 IP - 1 DP - 2026 Aug 27 TI - Multicentre validation of paediatric weight estimation methods in Indonesian children: a comparison of length-based, habitus-adjusted and age-based approaches. LID - 10.1136/bmjpo-2026-004495 [doi] LID - e004495 AB - BACKGROUND: Accurate weight estimation in paediatric emergencies is essential for determining appropriate drug dosage and equipment sizes. In Indonesia, where emergency tapes are not widely available, the 2011 Advanced Paediatric Life Support (APLS) formula is commonly used although its accuracy in the local population remains uncertain. This study aimed to evaluate and compare the accuracy of four weight estimation methods-the 2019 Broselow Tape, the 2022 Dose-by-Growth (DbG) Tape, the 2009 Paediatric Advanced Weight Prediction in the Emergency Room (PAWPER) Tape and the 2011 APLS formula. METHODS: This multicentre cross-sectional study included 1448 Indonesian children aged 0-12 years from two major hospitals. Estimated weights using the four methods were compared with actual body weight. Agreement was assessed using Bland-Altman plots, while accuracy was evaluated using the percentage of weight estimates within 10% and 20% of actual weight (PW10 and PW20). RESULTS: The PAWPER Tape demonstrated the highest accuracy (PW20=89.4%) with low bias (mean percentage error (MPE) 4.6+/-12.8%). The Broselow Tape (MPE 5.1+/-15.9%; PW20=82.7%) and DbG Tape (MPE 7.3+/-16.0%; PW20=79.6%) showed comparable performance. In contrast, the APLS formula had substantially greater bias and lower accuracy (MPE 14.0+/-28.5%; PW20=58.8%) and demonstrated consistent overestimation across most weight categories. CONCLUSION: PAWPER Tape showed the best accuracy and agreement with measured weight in Indonesian children followed by the Broselow and DbG Tapes. In contrast, the 2011 APLS formula performed poorly, with greater error and systematic overestimation. These findings support the use of length-based and habitus-adjusted methods in paediatric emergency settings. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Puspaningtyas, Niken Wahyu AU - Puspaningtyas NW AUID- ORCID: 0000-0002-5977-1577 AD - Paediatric Emergency and Intensive Therapy Division, Department of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia nikenwp2020@gmail.com. AD - Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia. FAU - Hidayat, Sharfina Fulki Adilla AU - Hidayat SFA AUID- ORCID: 0009-0009-2505-7445 AD - Paediatric Emergency and Intensive Therapy Division, Department of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia. AD - Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia. FAU - Tartila, Tartila AU - Tartila T AD - Paediatric Emergency and Intensive Therapy Division, Department of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia. AD - Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia. FAU - Prawira, Yogi AU - Prawira Y AD - Paediatric Emergency and Intensive Therapy Division, Department of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia. AD - Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia. FAU - Yuniar, Irene AU - Yuniar I AD - Paediatric Emergency and Intensive Therapy Division, Department of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia. AD - Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia. FAU - Nathania, Ilona AU - Nathania I AUID- ORCID: 0009-0005-5667-0710 AD - Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia. AD - Department of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia. FAU - Negoro, Fae Ilana AU - Negoro FI AD - Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia. AD - Department of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia. FAU - Sunukanto, Jennifer S AU - Sunukanto JS AD - Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia. AD - Department of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia. FAU - Dewi, Rismala AU - Dewi R AD - Paediatric Emergency and Intensive Therapy Division, Department of Child Health, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Indonesia. AD - Universitas Indonesia Fakultas Kedokteran, Jakarta, Indonesia. LA - eng PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20260827 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Indonesia MH - Cross-Sectional Studies MH - Child, Preschool MH - Female MH - Infant MH - Male MH - *Body Weight MH - Child MH - Infant, Newborn MH - *Anthropometry/methods MH - Reproducibility of Results PMC - PMC13536096 OTO - NOTNLM OT - Child Health OT - Children OT - Cross-Sectional Studies OT - Developing Countries OT - Resuscitation COIS- Competing interests: None declared. EDAT- 2026/08/28 11:40 MHDA- 2026/08/28 11:41 PMCR- 2026/08/27 CRDT- 2026/08/27 21:12 PHST- 2026/04/09 00:00 [received] PHST- 2026/08/15 00:00 [accepted] PHST- 2026/08/28 11:41 [medline] PHST- 2026/08/28 11:40 [pubmed] PHST- 2026/08/27 21:12 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - 10.1136/bmjpo-2026-004495 [pii] AID - bmjpo-2026-004495 [pii] AID - 10.1136/bmjpo-2026-004495 [doi] PST - epublish SO - BMJ Paediatr Open. 2026 Aug 27;10(1):e004495. doi: 10.1136/bmjpo-2026-004495. PMID- 42660285 OWN - NLM STAT- Publisher LR - 20260901 IS - 1559-2030 (Electronic) IS - 1551-7144 (Linking) VI - 170 DP - 2026 Aug 27 TI - 'eatNplay'- a family-based, telehealth intervention for childhood obesity: A randomized newsletter-controlled pilot study. PG - 108450 LID - S1551-7144(26)00236-3 [pii] LID - 10.1016/j.cct.2026.108450 [doi] AB - INTRODUCTION: Childhood obesity is a major public health concern in the United States. Telehealth interventions are a strategy to instill healthy lifestyle choices among children and their guardians by introducing and reinforcing healthy behaviors. OBJECTIVE: Our aim was to assess the feasibility of a telehealth intervention using motivational interviewing focusing on healthy behaviors in children. METHODS: Using a family-based, randomized, controlled, crossover trial design, 42 families with children aged 5-11 years were randomly assigned to an intervention group or newsletter control group. Participants were randomly divided into two groups. One group was assigned the intervention condition for four weeks (Phase-1, from the beginning of the study through 4 weeks), followed by a two-week washout period, then assigned to the newsletter control condition (Phase-2, from week 7 until the end of week 10.) The intervention consisted of weekly 'eatNplay' group telehealth sessions, conducted by a registered nurse and a motivational interviewing expert, to discuss diet, physical activity, screentime, and sleep. RESULTS: Participants' mean age was 8.8 +/- 1.8; 54% were female. Engagement scores and attendance were consistently high throughout the study. Dietary, activity, and sleep outcomes were compared to American Pediatrics Association recommendations for the age group. DISCUSSION: A telehealth intervention using motivational interviewing to address healthy behaviors in children was well received by participating families. This pilot study helped guide a planned future study that may be longer. Data from dietary intake, activity, and sleep are valuable to guide future studies. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Arce, Britney AU - Arce B AD - School of Nursing, Indiana University, United States of America. Electronic address: barce@iu.edu. FAU - Davis-Ajami, Mary Lynn AU - Davis-Ajami ML AD - College of Health, Cleveland State University, United States of America. Electronic address: m.davisajami@csuohio.edu. FAU - Ortyl, Bailey AU - Ortyl B AD - School of Public Health, Indiana University, United States of America. Electronic address: brtyl@iu.edu. FAU - Hartlieb, Kathryn AU - Hartlieb K AD - College Of Human Performance, Parker University, United States of America. Electronic address: kathrynhartlieb@parker.edu. FAU - Dickinson, Stephanie AU - Dickinson S AD - School of Public Health, Indiana University, United States of America. Electronic address: sd3@iu.edu. FAU - Golzarri-Arroyo, Lilian AU - Golzarri-Arroyo L AD - School of Public Health, Indiana University, United States of America. Electronic address: lgolzarr@iu.edu. FAU - Faith, Myles AU - Faith M AD - University at Buffalo, United States of America. Electronic address: mfaith@buffalo.edu. FAU - Jayawardene, Wasantha AU - Jayawardene W AD - School of Human Sciences, Southern Illinois University Carbondale, United States of America. Electronic address: wasantha@siu.edu. LA - eng PT - Journal Article DEP - 20260827 PL - United States TA - Contemp Clin Trials JT - Contemporary clinical trials JID - 101242342 SB - IM OTO - NOTNLM OT - Exercise OT - Family-based OT - Kids OT - Pediatric OT - Telehealth OT - Wellness COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/28 11:40 MHDA- 2026/08/28 11:40 CRDT- 2026/08/27 19:11 PHST- 2026/02/12 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/25 00:00 [accepted] PHST- 2026/08/28 11:40 [pubmed] PHST- 2026/08/28 11:40 [medline] PHST- 2026/08/27 19:11 [entrez] AID - S1551-7144(26)00236-3 [pii] AID - 10.1016/j.cct.2026.108450 [doi] PST - aheadofprint SO - Contemp Clin Trials. 2026 Aug 27;170:108450. doi: 10.1016/j.cct.2026.108450. PMID- 42658485 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261016 IS - 1878-6448 (Electronic) IS - 1053-8135 (Linking) VI - 59 IP - 3 DP - 2026 Nov TI - Autonomic Dysfunction After Pediatric Concussion: A Scoping Review. PG - 343-363 LID - 10.1177/10538135261479313 [doi] AB - PurposeA concussion is a common injury in children and adolescents. Despite how common these brain injuries are, relatively little is known about the underlying pathophysiology of pediatric concussion. This scoping review aims to collect and synthesize the literature on autonomic dysfunction (AD) in pediatric concussion, with a secondary aim to identify the procedures and measures testing autonomic function (AF).MethodsWe completed a systematic search using six databases of articles pertaining to AD after concussion. The resulting articles were exported, screened, and reviewed based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews (PRISMA-ScR) guidelines.ResultsTwenty-two studies met the study criteria and were included in the review. Findings revealed that children and adolescents experience varying degrees of AD after concussion. Fifteen of the 22 studies identified some anomaly related to AD in the concussed pediatric population, though the direction of findings varied across studies and injury phases. The most common autonomic assessment used in studies focused on cardiovascular autonomic reflex testing resulting from orthostatic stressors (n = 10), with other measures including respiratory effects during aerobic exercise and ocular dynamics.ConclusionOverall, there is a gap in our understanding of AD after pediatric concussion. The findings of this study provide mixed results on AD after pediatric concussion. Future research should prioritize prospective studies examining autonomic recovery trajectories across developmental subgroups. Autonomic measures, such as cardioregulatory measures and pupillometry, represent promising emerging markers that require further validation to inform rehabilitation protocols in pediatric concussion. FAU - Ramsay, Scott AU - Ramsay S AUID- ORCID: 0000-0001-5427-219X AD - School of Nursing, University of British Columbia, Vancouver, Canada. RINGGOLD: 8166 AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada. AD - BC Children's Hospital Research Institute, Vancouver, Canada. RINGGOLD: 512469 FAU - Lloyd, Hunter AU - Lloyd H AD - School of Nursing, University of British Columbia, Vancouver, Canada. RINGGOLD: 8166 AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, Canada. FAU - Kobzeva, Violetta AU - Kobzeva V AD - School of Nursing, University of British Columbia, Vancouver, Canada. RINGGOLD: 8166 FAU - Lee, James AU - Lee J AD - BC Children's Hospital Research Institute, Vancouver, Canada. RINGGOLD: 512469 AD - Department of Pediatrics, University of British Columbia, Vancouver, Canada. RINGGOLD: 8166 LA - eng PT - Journal Article PT - Review PT - Scoping Review DEP - 20260827 PL - United States TA - NeuroRehabilitation JT - NeuroRehabilitation JID - 9113791 SB - IM MH - Humans MH - *Autonomic Nervous System Diseases/etiology/physiopathology MH - *Brain Concussion/complications/physiopathology MH - Child MH - Adolescent MH - Autonomic Nervous System/physiopathology OTO - NOTNLM OT - adolescent OT - autonomic nervous system OT - brain concussion OT - child OT - parasympathetic nervous system OT - sympathetic nervous system COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/08/27 17:37 MHDA- 2026/10/08 17:35 CRDT- 2026/08/27 11:26 PHST- 2026/10/08 17:35 [medline] PHST- 2026/08/27 17:37 [pubmed] PHST- 2026/08/27 11:26 [entrez] AID - 10.1177/10538135261479313 [doi] PST - ppublish SO - NeuroRehabilitation. 2026 Nov;59(3):343-363. doi: 10.1177/10538135261479313. Epub 2026 Aug 27. PMID- 42658375 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20261008 IS - 1573-3327 (Electronic) IS - 0009-398X (Linking) VI - 57 IP - 5 DP - 2026 Oct TI - Evaluation of Oral Health in Children with Attention-Deficit/Hyperactivity Disorder: A Cross-Sectional Study. PG - 1275-1283 LID - 10.1007/s10578-026-02091-7 [doi] AB - This study aimed to compare the oral health profiles of children with Attention-Deficit/Hyperactivity Disorder (ADHD) and healthy controls, focusing on caries experience, periodontal status, and occlusal characteristics. In this cross-sectional study, children aged 10-18 years diagnosed with ADHD (n = 50) and age-matched healthy controls (n = 50) underwent standardized dental examinations. ADHD diagnoses were established by a child and adolescent psychiatry specialist based on DSM-5 criteria and supported by neuropsychological assessments. All dental evaluations were performed by a single blinded examiner under standardized clinical conditions. Assessments included DMFT scoring, clinical gingival evaluation, malocclusion analysis, dental crowding status, and panoramic radiographic evaluation. Children with ADHD had a significantly higher DMFT index than controls (2.82 +/- 1.38 vs. 1.10 +/- 1.02; p < 0.001). The odds of having a fractured tooth were higher in the ADHD group than in the control group (36% vs. 10%; unadjusted OR = 5.06, 95% CI: 1.70-15.05; p = 0.004). Any gingival abnormality was more frequent in the ADHD group than in the control group (60% vs. 12%; unadjusted OR = 11.00, 95% CI: 3.95-30.61; p < 0.001). Malocclusion (64% vs. 24%; p < 0.001) and dental crowding (70% vs. 44%; p = 0.015) were also more frequent among children with ADHD. Within this selected sample meeting predefined oral-hygiene, dietary, and dental-attendance criteria, ADHD was associated with poorer oral health indicators. These findings provide clinically relevant insights and may support tailored preventive monitoring and clinically indicated dental-mental health collaboration. Further studies involving larger and more diverse cohorts are warranted to validate these associations across the broader ADHD population. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Jaicks, Caglar Charles Daniel AU - Jaicks CCD AUID- ORCID: 0000-0003-4428-6912 AD - Child and Adolescent Psychiatry Department, Istanbul Aydin University, Istanbul, Turkey. caglarjaicks@yahoo.com. FAU - Kinter, Reyhan Calisan AU - Kinter RC AD - Child and Adolescent Psychiatry Department, Istanbul Aydin University, Istanbul, Turkey. FAU - Yeniugurel, Turgay AU - Yeniugurel T AD - Private Dental Clinic, Adana, Turkey. FAU - Yildirim, Cemile AU - Yildirim C AD - Private Psychological Counseling Clinic, Adana, Turkey. LA - eng PT - Journal Article DEP - 20260827 PL - United States TA - Child Psychiatry Hum Dev JT - Child psychiatry and human development JID - 1275332 SB - IM MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/epidemiology/complications MH - Child MH - Cross-Sectional Studies MH - Male MH - Female MH - *Oral Health/statistics & numerical data MH - Adolescent MH - DMF Index MH - *Malocclusion/epidemiology MH - *Dental Caries/epidemiology OTO - NOTNLM OT - ADHD OT - Dental caries OT - Malocclusion OT - Oral health OT - Pediatric dentistry COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/08/27 17:35 MHDA- 2026/09/26 05:34 CRDT- 2026/08/27 11:22 PHST- 2026/01/08 00:00 [received] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/09/26 05:34 [medline] PHST- 2026/08/27 17:35 [pubmed] PHST- 2026/08/27 11:22 [entrez] AID - 10.1007/s10578-026-02091-7 [pii] AID - 10.1007/s10578-026-02091-7 [doi] PST - ppublish SO - Child Psychiatry Hum Dev. 2026 Oct;57(5):1275-1283. doi: 10.1007/s10578-026-02091-7. Epub 2026 Aug 27. PMID- 42656734 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260828 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 7 DP - 2026 Jul TI - Internet Gaming Addiction in Children and Adolescents: A Narrative Review in the Context of Screen Time. PG - e113441 LID - 10.7759/cureus.113441 [doi] LID - e113441 AB - Internet gaming addiction in children and adolescents is an emerging clinical and public health concern within the broader context of increasing recreational screen exposure. Despite growing recognition of gaming disorder, uncertainty remains regarding its distinction from high recreational gaming, its relationship with screen time, and the most appropriate prevention and management strategies for pediatric populations. This narrative review aimed to synthesise evidence published between 2013 and 2026 on diagnostic concepts, epidemiological patterns, screen-time context, mental and physical health associations, and intervention approaches for problematic gaming in children and adolescents. Relevant literature was reviewed and organised into diagnostic, clinical, public health, and therapeutic domains. The conclusions were derived from qualitative narrative synthesis rather than pooled quantitative analysis. Current evidence indicates that gaming disorder should not be defined by screen-time duration alone, but by impaired control, persistence despite harm, prioritisation of gaming over essential activities, and functional impairment across academic, social, developmental, and family domains. Prevalence estimates vary because of differences in diagnostic criteria, assessment tools, cultural gaming practices, and study populations. Excessive gaming commonly overlaps with emotional symptoms, sleep disturbance, sedentary behaviour, reduced physical activity, academic difficulties, social withdrawal, and family conflict. Available evidence suggests potential benefit from multidimensional management involving validated assessment, cognitive behavioural strategies, relapse prevention, parental involvement, school-based digital literacy, structured offline activities, and coordinated pediatric mental health care. Screen-time reduction is important, but restriction alone is insufficient. Given the absence of formal evidence grading and risk-of-bias assessment, conclusions regarding intervention effectiveness should be interpreted cautiously. Pediatric gaming disorder requires impairment-based assessment and developmentally appropriate, family-supported intervention rather than simple screen-time control. CI - Copyright (c) 2026, Sharma et al. FAU - Sharma, Neena AU - Sharma N AD - Department of Physiology, All India Institute of Medical Sciences (AIIMS), Jammu, Jammu, IND. LA - eng PT - Journal Article PT - Review DEP - 20260727 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13508007 OTO - NOTNLM OT - adolescents OT - gaming disorder OT - internet gaming addiction OT - pediatric mental health OT - screen time COIS- Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/08/27 12:36 MHDA- 2026/08/27 12:37 PMCR- 2026/07/27 CRDT- 2026/08/27 06:08 PHST- 2026/07/24 00:00 [accepted] PHST- 2026/08/27 12:37 [medline] PHST- 2026/08/27 12:36 [pubmed] PHST- 2026/08/27 06:08 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 10.7759/cureus.113441 [doi] PST - epublish SO - Cureus. 2026 Jul 27;18(7):e113441. doi: 10.7759/cureus.113441. eCollection 2026 Jul. PMID- 42656511 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260828 IS - 2347-5625 (Print) IS - 2349-6673 (Electronic) IS - 2347-5625 (Linking) VI - 13 DP - 2026 Dec TI - Development and preliminary validation of the Exercise Fit Tool for adolescents undergoing cancer treatment in Hong Kong. PG - 101005 LID - 10.1016/j.apjon.2026.101005 [doi] LID - 101005 AB - OBJECTIVE: This study aimed to develop and preliminarily validate the Exercise Fit Tool (EFT), a patient-reported self-assessment tool for adolescents undergoing cancer treatment in Hong Kong. METHODS: A convenience sample of 158 adolescents aged 13-18 years who were undergoing cancer treatment and could communicate in Cantonese and read Chinese was recruited in Hong Kong. Instrument development followed the procedures recommended in AMEE Guide No. 87. Candidate items were generated from a literature review and focus groups with adolescents and healthcare professionals, refined by an expert panel, assessed for content validity, and revised through cognitive interviews. Pilot testing was conducted in 158 adolescents. Convergent validity was examined using pain scores and forced expiratory volume in 1 second (FEV1, % predicted), and criterion-related validity was evaluated by comparing EFT scores with physiotherapists' ratings. Test-retest reliability was assessed in 50 participants, and principal component analysis with Varimax rotation was performed. RESULTS: The final 10-item EFT demonstrated satisfactory content validity, with I-CVIs ranging from 0.86 to 1.00, and good internal consistency (Cronbach's alpha = 0.92). The 2-week test-retest ICC was 0.82 (P < 0.001). EFT scores were negatively correlated with pain scores and positively correlated with FEV1 (% predicted), supporting convergent validity. The Kaiser-Meyer-Olkin measure was 0.87, and Bartlett's test of sphericity was significant (P < 0.001). Principal component analysis identified a two-component solution: cancer- and treatment-related influences on physical activity (7 items; Cronbach's alpha = 0.96; 55.7% of the rotated variance) and perceived physical activity exertion (3 items; Cronbach's alpha = 0.74; 20.6% of the rotated variance). Primary component loadings ranged from 0.74 to 0.93, and communalities ranged from 0.55 to 0.91. The two components explained 76.3% of the total variance. CONCLUSIONS: The EFT demonstrated preliminary evidence of validity and reliability for adolescents undergoing cancer treatment in Hong Kong. Further evaluation of its latent structure and implementation in independent samples is required before wider clinical use. CI - (c) 2026 The Author(s). FAU - Lam, Katherine Ka Wai AU - Lam KKW AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Wu, Stanley AU - Wu S AD - Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong SAR, China. FAU - Liu, Qi AU - Liu Q AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Mao, Ting AU - Mao T AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Pan, Jingda AU - Pan J AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Jiang, Lulu AU - Jiang L AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Li, Yanjia AU - Li Y AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Gao, Yuwen AU - Gao Y AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. FAU - Cheng, Frankie Wai Tsoi AU - Cheng FWT AD - Hong Kong Children's Hospital, Hong Kong SAR, China. FAU - Chan, Godfrey Chi Fung AU - Chan GCF AD - Department of Paediatrics and Adolescent Medicine, School of Clinical Medicine, LKS Faculty of Medicine The University of Hong Kong, Hong Kong SAR, China. FAU - Ho, Ka Yan AU - Ho KY AD - School of Nursing, The Hong Kong Polytechnic University, Hong Kong, China. LA - eng PT - Journal Article DEP - 20260711 PL - United States TA - Asia Pac J Oncol Nurs JT - Asia-Pacific journal of oncology nursing JID - 101673157 PMC - PMC13506534 OTO - NOTNLM OT - Adolescents OT - Cancer OT - Patient-reported outcome OT - Physical activity OT - Reliability OT - Validation COIS- The authors declare no conflict of interest. EDAT- 2026/08/27 12:36 MHDA- 2026/08/27 12:37 PMCR- 2026/07/11 CRDT- 2026/08/27 05:40 PHST- 2025/11/11 00:00 [received] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/08/27 12:37 [medline] PHST- 2026/08/27 12:36 [pubmed] PHST- 2026/08/27 05:40 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - S2347-5625(26)00155-1 [pii] AID - 101005 [pii] AID - 10.1016/j.apjon.2026.101005 [doi] PST - epublish SO - Asia Pac J Oncol Nurs. 2026 Jul 11;13:101005. doi: 10.1016/j.apjon.2026.101005. eCollection 2026 Dec. PMID- 42656224 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260828 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Developing and evaluating a multidimensional progress-based assessment standard for standing long jump performance in university physical education: a sequential mixed-methods study. PG - 1861330 LID - 10.3389/fpsyg.2026.1861330 [doi] LID - 1861330 AB - Physical education assessments that count toward university admission or course grades typically measure only a student's fitness at a single time point, overlooking incremental progress and thus providing little incentive for those with lower baseline performance. This study evaluated the feasibility of a multidimensional scoring method that captures changes in standing long jump performance, an indicator of lower-limb explosive power and better reflects student learning. This study had two phases. Phase 1 combined a two-round Delphi process, AHP weighting, and standing long jump data from 211 classes (N = 4,109) to develop the multidimensional evaluation model. Phase 2 is a quasi-experimental study where 4 year 1-2 university classes was randomly selected and assigned to the intervention (IG) and control group (CG). Learning motivation was measured using the college student version of the Work Preference Inventory. Difference-in-difference model was used to analyze the association between motivation and standing long jump distance (post-pre) between IG and CG. Both IG and CG showed significant improvements in both standing long jump and motivation, with IG having significantly better outcomes. The time interaction between the groups confirmed the statistical significance. The OLS regression results showed both internal motivation (p < 0.001) and external motivation (p < 0.001) had significant positive relationship. Both boys' (p < 0.001) and girls' (p = 0.029) showed significant improvement. These findings suggest that a multidimensional, progress-sensitive scoring system can enhance students' motivation and foster positive behavioral change in physical education. CI - Copyright (c) 2026 Zhang, Zhang, Yang and Lin. FAU - Zhang, Wenyu AU - Zhang W AD - School of Physical Education, Minzu University of China, Beijing, China. AD - Faculty of Education, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia. FAU - Zhang, Fengmin AU - Zhang F AD - School of Physical Education, Minzu University of China, Beijing, China. FAU - Yang, Haipeng AU - Yang H AD - Faculty of Education, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia. FAU - Lin, Xiaofeng AU - Lin X AD - Faculty of Education, Universiti Kebangsaan Malaysia, Bangi, Selangor, Malaysia. LA - eng PT - Journal Article DEP - 20260812 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13506395 OTO - NOTNLM OT - evaluation criteria OT - learning motivation OT - multidimensional evaluation OT - physical education assessment OT - sequential mixed-methods COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/12 CRDT- 2026/08/27 04:56 PHST- 2026/04/21 00:00 [received] PHST- 2026/07/14 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 04:56 [entrez] PHST- 2026/08/12 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1861330 [doi] PST - epublish SO - Front Psychol. 2026 Aug 12;17:1861330. doi: 10.3389/fpsyg.2026.1861330. eCollection 2026. PMID- 42654495 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 62 IP - 8 DP - 2026 Aug 20 TI - Maternal Vulnerability Indicators Derived from Free-Text Clinical Documentation in Adolescent Pregnancy. LID - 10.3390/medicina62081598 [doi] LID - 1598 AB - Background and Objectives: Adolescent pregnancy is associated with biological, behavioral, and healthcare-related vulnerabilities that are incompletely captured by structured datasets. This study aimed to characterize selected maternal vulnerability indicators derived from narrative clinical documentation and to examine their exploratory associations with documented prenatal care deficiency and neonatal outcomes. Materials and Methods: We conducted a retrospective cohort study including 759 singleton adolescent pregnancies managed at a Romanian secondary obstetric center between 2020 and 2024. Narrative clinical observations were reviewed to extract maternal vulnerability indicators, including smoking, anemia, infection, hypertensive disorders, obesity, Rh incompatibility, and documented prenatal care deficiency. Associations between extracted variables, documented prenatal care deficiency, and neonatal outcomes were evaluated using contingency analyses, Kendall's tau-b correlations, and multivariable logistic regression models. Results: Among pregnancies with available narrative observations, documented prenatal care deficiency was identified in 612/692 (88.4%), maternal anemia in 207/692 (29.9%), and smoking during pregnancy in 186/692 (26.9%). Validation performance differed across categories, with a sensitivity of 57.1% (95% CI 18.4-90.1%) for hypertensive disorders and wide confidence intervals for rare categories. Correlations between extracted variables were weak, indicating limited clustering of maternal risk factors. Hypertensive disorders (aOR 0.31, 95% CI 0.10-0.95, p = 0.038) and maternal obesity (aOR 0.39, 95% CI 0.16-0.98, p = 0.044) were associated with lower odds of documented prenatal care deficiency. Significant neonatal associations were observed primarily for low birth weight. Hypertensive disorders were independently associated with increased odds of low birth weight (aOR 3.56, 95% CI 1.33-9.54, p = 0.011), whereas documented maternal anemia was associated with lower observed odds of LBW (aOR 0.45, 95% CI 0.24-0.82, p = 0.009). No significant associations were identified for preterm birth or Apgar score < 7 at 5 min. Conclusions: Narrative clinical documentation allowed the identification of heterogeneous maternal vulnerability indicators that showed weak interrelationships and selective associations with prenatal surveillance patterns and low birth weight. These exploratory findings should be interpreted in the context of healthcare engagement and documentation practices. FAU - Sandor, Florin Mihai AU - Sandor FM AUID- ORCID: 0009-0008-4137-7388 AD - Multidisciplinary Doctoral School, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania. AD - Department of Life Sciences, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania. FAU - Precup, Cris Virgiliu AU - Precup CV AUID- ORCID: 0009-0009-4299-5652 AD - Department of Life Sciences, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania. FAU - Furau, Cristian George AU - Furau CG AUID- ORCID: 0000-0001-7158-2579 AD - Multidisciplinary Doctoral School, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania. AD - Department of Life Sciences, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania. FAU - Edu, Antoine AU - Edu A AD - Department 13-Obstetrics and Gynecology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania. AD - Nicolae Malaxa Clinical Hospital, 022441 Bucharest, Romania. FAU - Edu, Mihnea-Dan AU - Edu MD AD - Department 13-Obstetrics and Gynecology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania. AD - Nicolae Malaxa Clinical Hospital, 022441 Bucharest, Romania. FAU - Coroleuca, Ciprian AU - Coroleuca C AUID- ORCID: 0000-0002-2043-9307 AD - Department 13-Obstetrics and Gynecology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania. AD - Panait Sarbu Clinical Hospital of Obstetrics and Gynecology, 060251 Bucharest, Romania. FAU - Furau, Roxana AU - Furau R AD - Department of General Medicine, Faculty of Medicine, "Vasile Goldis" Western University of Arad, 310414 Arad, Romania. FAU - Rosca, Ioana AU - Rosca I AUID- ORCID: 0009-0002-4629-5820 AD - Panait Sarbu Clinical Hospital of Obstetrics and Gynecology, 060251 Bucharest, Romania. AD - Faculty of Midwifery and Nursery, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania. FAU - Mateescu, Radu Nicolae AU - Mateescu RN AD - Department 13-Obstetrics and Gynecology, Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 020021 Bucharest, Romania. AD - Nicolae Malaxa Clinical Hospital, 022441 Bucharest, Romania. LA - eng PT - Journal Article DEP - 20260820 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adolescent MH - Retrospective Studies MH - *Pregnancy in Adolescence/statistics & numerical data MH - Romania/epidemiology MH - *Prenatal Care/statistics & numerical data/standards MH - Cohort Studies MH - *Documentation/methods/statistics & numerical data/standards MH - Pregnancy Complications/epidemiology MH - Risk Factors MH - Logistic Models MH - Pregnancy Outcome/epidemiology MH - Infant, Newborn PMC - PMC13515706 OTO - NOTNLM OT - adolescent pregnancy OT - low birth weight OT - maternal vulnerability OT - narrative clinical documentation OT - perinatal epidemiology OT - prenatal care deficiency OT - routinely collected health data COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/20 CRDT- 2026/08/27 01:10 PHST- 2026/07/16 00:00 [received] PHST- 2026/08/05 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:10 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - medicina62081598 [pii] AID - medicina-62-01598 [pii] AID - 10.3390/medicina62081598 [doi] PST - epublish SO - Medicina (Kaunas). 2026 Aug 20;62(8):1598. doi: 10.3390/medicina62081598. PMID- 42654307 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 16 DP - 2026 Aug 20 TI - Social Media and out of Home Food Selection and Health Promoting Choices: A Generational Perspective in Poland. LID - 10.3390/nu18162727 [doi] LID - 2727 AB - OBJECTIVE: This study investigates the relationship between social media use and consumer purchase intentions or out-of-home food choices in the Polish gastronomic market, focusing specifically on variations across generations. METHODOLOGY: Data were collected between May and July 2024 through a diagnostic survey using the Computer-Assisted Web Interviewing (CAWI) technique (N = 1099). Respondents were recruited via a non-probability quota sampling approach based on strict demographic inclusion criteria. To test the research hypotheses regarding generational variations in market behaviour, a multivariate discriminant function analysis was performed using Statistica 13.1 PL. A preliminary pilot study (N = 30) confirmed the initial questionnaire readability and overall consistency (Cronbach's alpha = 0.87), while subscales were treated independently during the main analysis. RESULTS: Multivariate models were found to be highly significant, revealing clear differences between age groups. The youngest cohort (aged 18-35) relies heavily on Instagram and TikTok, showing distinct patterns regarding visual triggers such as "instagrammable" aesthetics, digital validation, and menu uniqueness alongside weight loss claims. Conversely, seniors (aged 61 and older) lean unexpectedly towards X. This older segment displays pragmatic, utility-driven motives, searching for detailed textual data about ingredients and the health-promoting properties of food. General product quality and calorie control were identified as universal factors that do not vary by generation. Conclusions and Managerial Implications: The digital transformation of the Polish restaurant industry does not follow a single path. Social media is closely linked to modern customer journeys, with physical dining spots frequently serving as spaces for socialisation. Consequently, restaurant operators should move away from mass communication and adopt a selective omnichannel strategy, where message formats shift from visual appeal to factual, nutrition-oriented text that is tailored to the digital literacy and dietary needs of each generation. FAU - Soroka, Andrzej AU - Soroka A AD - Faculty of Medical and Health Sciences, University of Siedlce, Boleslawa. Prusa 14, 08-110 Siedlce, Poland. FAU - Godlewska, Agnieszka AU - Godlewska A AD - Faculty of Medical and Health Sciences, University of Siedlce, Boleslawa. Prusa 14, 08-110 Siedlce, Poland. FAU - Mazurek-Kusiak, Anna Katarzyna AU - Mazurek-Kusiak AK AUID- ORCID: 0000-0002-3786-8861 AD - Department of Tourism and Recreation, University of Life Sciences in Lublin, Akademicka 15, 20-950 Lublin, Poland. LA - eng GR - 233/26/B/Ministry of Science and Higher Education/ PT - Journal Article DEP - 20260820 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Poland MH - *Food Preferences/psychology MH - *Social Media/statistics & numerical data MH - Female MH - Middle Aged MH - Adult MH - *Consumer Behavior/statistics & numerical data MH - *Choice Behavior MH - Male MH - Adolescent MH - *Health Promotion MH - Young Adult MH - Surveys and Questionnaires MH - Aged MH - Digital Media PMC - PMC13516072 OTO - NOTNLM OT - consumer behaviour OT - discriminant function analysis OT - food choices OT - gastronomic market OT - intergenerational differences OT - social media COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/20 CRDT- 2026/08/27 01:10 PHST- 2026/07/15 00:00 [received] PHST- 2026/08/16 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:10 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - nu18162727 [pii] AID - nutrients-18-02727 [pii] AID - 10.3390/nu18162727 [doi] PST - epublish SO - Nutrients. 2026 Aug 20;18(16):2727. doi: 10.3390/nu18162727. PMID- 42654292 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 16 DP - 2026 Aug 19 TI - Reproducibility of a 69-Item School Children's Food Frequency Questionnaire (69-Item SCh-FFQ) and Diet Quality Scores Among Polish Children Aged 7-9 Years. LID - 10.3390/nu18162712 [doi] LID - 2712 AB - Background/Objectives: Reliable dietary assessment tools are essential for evaluating dietary habits and diet quality in children. The aim of this study was to assess the reproducibility of a 69-item School Children's Food Frequency Questionnaire (69-item SCh-FFQ) and the diet quality scores among Polish children aged 7-9 years. Methods: The reproducibility study was conducted among 77 children. The 69-item SCh-FFQ was administered twice (test and retest). Data on food consumption frequency were used to evaluate two diet quality scores: the pro-Healthy Diet Index (pHDI) and the non-Healthy Diet Index (nHDI). The reproducibility of the 69-item SCh-FFQ and the diet quality scores was evaluated using comparisons of mean values, cross-classification analysis, Cohen's kappa statistic, Spearman's rank correlation coefficient, intraclass correlation coefficient (ICC), and Bland-Altman analysis. Results: No significant differences were observed between test and retest of the FFQ for mean values of the pHDI (2.9 +/- 1.8 vs. 2.8 +/- 1.9 points; p = 0.124) or the nHDI (4.3 +/- 1.5 vs. 4.2 +/- 1.5 points; p = 0.611). Total agreement for the classification of children into categories of the diet quality scores reached 81.8% for pHDI and 75.3% for nHDI, with low gross misclassification rates (1.3% and 0.0%, respectively). Cohen's kappa statistic indicated moderate to good agreement (kappa = 0.68 for pHDI and kappa = 0.51 for nHDI). For all food items, total agreement ranged from 66.2% to 94.8%, while the kappa statistic ranged from 0.56 to 0.81. Strong correlations and good agreement were observed between repeated measurements for both pHDI (r = 0.748, ICC = 0.778; p < 0.001) and nHDI (r = 0.783, ICC = 0.752; p < 0.001). Bland-Altman analysis demonstrated good agreement and no evidence of proportional bias. Conclusions: The 69-item SCh-FFQ demonstrated satisfactory reproducibility for assessing food consumption frequency and diet quality scores in children aged 7-9 years. Therefore, this questionnaire is a promising tool for future epidemiological studies among early school-aged children, although its utility should be confirmed in further validation studies using an appropriate reference method. FAU - Sobas, Kamila AU - Sobas K AUID- ORCID: 0000-0003-4246-6944 AD - Institute of Health Sciences, Medical College, Jan Kochanowski University, 5 Zeromskiego Street, 25-369 Kielce, Poland. FAU - Kowalkowska, Joanna AU - Kowalkowska J AUID- ORCID: 0000-0003-1981-7320 AD - Department of Human Nutrition, Faculty of Food Science, University of Warmia and Mazury in Olsztyn, 45F Sloneczna Street, 10-718 Olsztyn, Poland. FAU - Suliga, Edyta AU - Suliga E AUID- ORCID: 0000-0003-3063-0380 AD - Institute of Health Sciences, Medical College, Jan Kochanowski University, 5 Zeromskiego Street, 25-369 Kielce, Poland. AD - Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, 36A Postepu Street, 05-552 Magdalenka, Poland. FAU - Wadolowska, Lidia AU - Wadolowska L AUID- ORCID: 0000-0001-8571-9935 AD - Department of Human Nutrition, Faculty of Food Science, University of Warmia and Mazury in Olsztyn, 45F Sloneczna Street, 10-718 Olsztyn, Poland. LA - eng PT - Journal Article DEP - 20260819 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Reproducibility of Results MH - Poland MH - Female MH - Male MH - *Feeding Behavior MH - *Diet Surveys MH - *Nutrition Assessment MH - Surveys and Questionnaires MH - *Diet MH - *Diet, Healthy PMC - PMC13516586 OTO - NOTNLM OT - diet quality OT - dietary assessment OT - food consumption frequency OT - reliability OT - school-aged children COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/19 CRDT- 2026/08/27 01:10 PHST- 2026/07/02 00:00 [received] PHST- 2026/08/17 00:00 [revised] PHST- 2026/08/18 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:10 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - nu18162712 [pii] AID - nutrients-18-02712 [pii] AID - 10.3390/nu18162712 [doi] PST - epublish SO - Nutrients. 2026 Aug 19;18(16):2712. doi: 10.3390/nu18162712. PMID- 42654285 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 16 DP - 2026 Aug 19 TI - Human Milk Sodium Monitoring Across the Continuum of Lactation: From Secretory Activation to Established Lactation. LID - 10.3390/nu18162705 [doi] LID - 2705 AB - Background: Human milk sodium (Na) concentration is a biomarker of lactation physiology and secretory activation, but conventional measurement methods are impractical for routine breastfeeding support. Portable Na analyzers may enable real-time home monitoring. Objective: The purpose of this study was to characterize longitudinal changes in human milk Na concentrations during the first 3 postpartum months and to evaluate the feasibility of longitudinal home Na monitoring throughout established lactation. Methods: Nine healthy lactating mothers intending to breastfeed were recruited at a breastfeeding management clinic in Tokyo, Japan, between August 2025 and December 2025. Participants performed home-based Na measurements from both breasts from birth through approximately 100 days postpartum, with the planned monitoring schedule defined as 90 postpartum days for adherence assessment. Each measurement required 2-3 drops of milk and was completed within 1 min. Longitudinal Na trajectories and Na elevation episodes were evaluated. Results: Na concentrations were highest immediately after birth and declined rapidly during the first postpartum week. Six of nine participants (66.7%) reached concentrations below 413.8 ppm within the first 7 postpartum days, and five of nine (55.6%) reached concentrations below 220 ppm by postpartum day 8. During established lactation, 62 breast-level Na elevation episodes were identified, with substantial interindividual variation in frequency and duration. Some episodes occurred without overt breast symptoms. Frequent home monitoring detected transient physiological fluctuations that would likely have been missed by conventional intermittent sampling. Conclusions: Longitudinal home milk Na monitoring was feasible in this small pilot cohort and enabled characterization of Na fluctuations from secretory activation through established lactation. These findings are preliminary and hypothesis-generating, and larger prospective studies are required to determine the clinical utility of longitudinal Na monitoring for breastfeeding assessment. FAU - Mizuno, Katsumi AU - Mizuno K AUID- ORCID: 0000-0002-6983-8851 AD - Department of Pediatrics, Showa Medical University, 1-5-8, Hatanodai, Shinagawa-ku, Tokyo 142-8666, Japan. FAU - Himi, Tomoko AU - Himi T AD - The Oketani Breastfeeding Management Research Institute, 20-8, Kikuicho, Shinjuku-ku, Tokyo 162-0044, Japan. LA - eng PT - Journal Article DEP - 20260819 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 9NEZ333N27 (Sodium) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Milk, Human/chemistry MH - *Lactation/physiology/metabolism MH - *Sodium/analysis/metabolism MH - Adult MH - Breast Feeding MH - Longitudinal Studies MH - Postpartum Period MH - Biomarkers/analysis MH - Infant, Newborn PMC - PMC13516742 OTO - NOTNLM OT - home monitoring OT - human milk OT - lactation support OT - secretory activation OT - sodium COIS- HORIBA Ltd. provided the portable sodium analyzer used in this study on loan. The company had no role in the study design, data collection, data analysis, interpretation of the data, manuscript preparation, or the decision to submit the manuscript for publication. The authors declare no other conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 12:35 PMCR- 2026/08/19 CRDT- 2026/08/27 01:10 PHST- 2026/07/16 00:00 [received] PHST- 2026/08/15 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/08/27 12:35 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:10 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - nu18162705 [pii] AID - nutrients-18-02705 [pii] AID - 10.3390/nu18162705 [doi] PST - epublish SO - Nutrients. 2026 Aug 19;18(16):2705. doi: 10.3390/nu18162705. PMID- 42654273 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 16 DP - 2026 Aug 18 TI - Maternal Dietary B-Complex Vitamin Pattern and Risk of Complex Congenital Heart Defects in a Mexican Population. LID - 10.3390/nu18162693 [doi] LID - 2693 AB - BACKGROUND/OBJECTIVES: Congenital heart defects (CHDs) are among the most common congenital anomalies worldwide, and maternal nutrition during early pregnancy may influence their development. Although previous studies have mainly evaluated individual B-complex vitamins, the contribution of their combined dietary intake to CHD risk remains poorly understood. This study investigated the association between maternal dietary B-complex vitamin intake and the risk of complex CHDs in a Mexican case-control study. METHODS: Maternal dietary intake during pregnancy was assessed using a validated food frequency questionnaire, and nutrient intakes were energy-adjusted. Principal component analysis was used to construct a B-Complex Index based on the combined intake of vitamins B1, B2, B3, B6, and B12. Associations were evaluated using multivariable logistic regression adjusted for maternal age, total energy intake, multivitamin supplementation during pregnancy, and periconceptional folic acid supplementation. RESULTS: Mothers of children with complex CHDs had significantly lower dietary intakes of B-complex vitamins than control mothers. The B-Complex Index was independently associated with lower odds of complex CHDs (adjusted OR = 0.707, 95% CI: 0.586-0.843; p = 0.0001). CONCLUSIONS: These findings suggest that evaluating the overall maternal dietary pattern of selected B-complex vitamins may provide complementary information regarding the nutritional environment relevant to early cardiac development. Prospective studies integrating dietary assessment, biomarkers, and genetic susceptibility are warranted to confirm these findings and further elucidate the underlying biological mechanisms. FAU - Vilchis-Gil, Jenny AU - Vilchis-Gil J AUID- ORCID: 0000-0002-5473-6772 AD - Unidad de Investigacion Epidemiologica en Endocrinologia y Nutricion, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. AD - Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Mexico City 04510, Mexico. FAU - Gomez-Jimenez, Aaron M AU - Gomez-Jimenez AM AUID- ORCID: 0009-0003-1099-0431 AD - Departamento de Matematicas, Facultad de Ciencias, Universidad Nacional Autonoma de Mexico, Mexico City 04510, Mexico. FAU - Santillan-Orgas, Maria E AU - Santillan-Orgas ME AD - Departamento de Neonatologia, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. FAU - Segura-Stanford, Begona AU - Segura-Stanford B AD - Departamento de Cardiologia, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. FAU - Navarro-Castellanos, Inaki AU - Navarro-Castellanos I AUID- ORCID: 0000-0002-7680-0835 AD - Departamento de Cardiologia, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. FAU - Gomez-Lopez, Jacqueline AU - Gomez-Lopez J AD - Hospital Militar de Especialidades de la Mujer y Neonatologia, Secretaria de la Defensa Nacional, Mexico City 11200, Mexico. FAU - Moran-Espinosa, Mari C AU - Moran-Espinosa MC AD - Laboratorio de Investigacion en Patogenesis Molecular, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. FAU - Granados-Riveron, Javier T AU - Granados-Riveron JT AD - Laboratorio de Investigacion en Patogenesis Molecular, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. FAU - Sanchez-Urbina, Rocio AU - Sanchez-Urbina R AUID- ORCID: 0000-0001-8018-7749 AD - Laboratorio de Investigacion en Cardiogenetica, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. AD - Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico City 11340, Mexico. LA - eng GR - HIM/2019/049/Hospital Infantil de Mexico Federico Gomez/ PT - Journal Article DEP - 20260818 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 12001-76-2 (Vitamin B Complex) SB - IM MH - Humans MH - Female MH - *Heart Defects, Congenital/epidemiology/etiology/prevention & control MH - Mexico/epidemiology MH - Pregnancy MH - *Maternal Nutritional Physiological Phenomena MH - Case-Control Studies MH - Adult MH - *Vitamin B Complex/administration & dosage MH - Risk Factors MH - *Diet MH - Dietary Supplements MH - Young Adult PMC - PMC13516518 OTO - NOTNLM OT - B-complex vitamins OT - congenital heart defects OT - maternal nutrition OT - one-carbon metabolism OT - pregnancy OT - principal component analysis COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/18 CRDT- 2026/08/27 01:10 PHST- 2026/06/29 00:00 [received] PHST- 2026/08/03 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:10 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - nu18162693 [pii] AID - nutrients-18-02693 [pii] AID - 10.3390/nu18162693 [doi] PST - epublish SO - Nutrients. 2026 Aug 18;18(16):2693. doi: 10.3390/nu18162693. PMID- 42654217 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 16 DP - 2026 Aug 12 TI - Development and Validation of the Food Consumption Rate Questionnaire (FCRQ): A Behaviorally Informed Measure of Eating-Rate Regulation. LID - 10.3390/nu18162637 [doi] LID - 2637 AB - Background: Eating-rate regulation is a multidimensional behavioral process shaped by oral-processing dynamics, interoceptive cues, sensory engagement, and contextual influences. Despite its relevance, no validated self-report instrument currently assesses these mechanisms. Methods: The Food Consumption Rate Questionnaire (FCRQ) was developed as a behaviorally informed tool for measuring eating-rate regulation. Item generation followed a theory-driven process supported by expert review, forward-backward translation, and pilot testing. Structural validity was examined through Exploratory Factor Analysis (Principal Axis Factoring, Promax rotation) and a theory-driven Confirmatory Factor Analysis evaluating the proposed four-domain model. Reliability was assessed using Cronbach's alpha and corrected item-total correlations. Behavioral heterogeneity was explored using hierarchical and k-means cluster analysis. Results: A clear four-factor structure emerged-Slowness, Awareness of Eating Rate, External Factors, and Awareness & Enjoyment-explaining 42.77% of the variance. CFA indicated acceptable model fit (CFI = 0.93, TLI = 0.91, RMSEA = 0.052), supporting the adequacy of the theoretical structure. Reliability indices were consistent with the multidimensional nature of the construct. All four domains were positively correlated. Cluster analysis identified distinct behavioral profiles, illustrating the instrument's discriminative capacity. Conclusions: The FCRQ provides the first behaviorally informed, psychometrically evaluated framework for assessing eating-rate regulation. The instrument demonstrates a coherent theoretical structure, satisfactory early-stage validity, and the ability to differentiate meaningful behavioral patterns. Continued refinement and validation across diverse populations will further establish the FCRQ as a robust measure for behavioral-nutrition research and practice. FAU - Koliou, Maria P AU - Koliou MP AUID- ORCID: 0009-0009-1751-5629 AD - Laboratory of Food Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. FAU - Karaiskou, Chrysoula AU - Karaiskou C AD - Sidroco Holdings Ltd., Nicosia 1082, Cyprus. FAU - Eleftheriadis, Charalampos AU - Eleftheriadis C AUID- ORCID: 0000-0002-0726-4127 AD - Sidroco Holdings Ltd., Nicosia 1082, Cyprus. FAU - Skalkos, Dimitris AU - Skalkos D AUID- ORCID: 0000-0002-7771-2845 AD - Laboratory of Food Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. LA - eng PT - Journal Article PT - Validation Study DEP - 20260812 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Reproducibility of Results MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires/standards MH - Psychometrics MH - Female MH - Factor Analysis, Statistical MH - Male MH - Adult MH - *Eating/psychology MH - Young Adult MH - Adolescent PMC - PMC13516422 OTO - NOTNLM OT - Food Consumption Rate Questionnaire (FCRQ) OT - behavioral nutrition OT - confirmatory factor analysis OT - eating-rate regulation OT - factor analysis OT - interoceptive awareness OT - psychometric evaluation OT - questionnaire development OT - questionnaire validation OT - sensory engagement COIS- C.K. and C.E. were employed by Sidroco Holdings Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/12 CRDT- 2026/08/27 01:09 PHST- 2026/07/25 00:00 [received] PHST- 2026/08/09 00:00 [revised] PHST- 2026/08/11 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:09 [entrez] PHST- 2026/08/12 00:00 [pmc-release] AID - nu18162637 [pii] AID - nutrients-18-02637 [pii] AID - 10.3390/nu18162637 [doi] PST - epublish SO - Nutrients. 2026 Aug 12;18(16):2637. doi: 10.3390/nu18162637. PMID- 42653984 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 1420-3049 (Electronic) IS - 1420-3049 (Linking) VI - 31 IP - 16 DP - 2026 Aug 20 TI - Exploring the Suitability of High-Performance Thin-Layer Chromatography for the Analysis of Drug Admixtures in Total Parenteral Nutrition Using Caffeine, Ibuprofen and Midazolam as Model Drugs. LID - 10.3390/molecules31162904 [doi] LID - 2904 AB - Total parenteral nutrition (TPN) is a nutritional therapy in children when oral or enteral feeding is not possible, fails to meet nutritional requirements or is contraindicated due to underlying clinical conditions. There are many cases where children who are given one or more than one intravenous medication also need TPN. In order to minimise vein access, these medications are commonly administered via a Y-site IV connection where they admix with TPN, implying a need for compatibility studies before admixing the medication into the nutritional fluid. In this study, previously developed and validated HPTLC methods were verified for their suitability to evaluate the concentrations of three commonly used medications in neonatal intensive care units (NICUs), namely caffeine citrate, ibuprofen arginine, and midazolam hydrochloride. Silica gel 60 F254 HPTLC plates were used as the stationary phase, and acetone: toluene: chloroform (4:3:3, v/v/v), toluene: methanol: ethyl acetate: glacial acetic acid (5.5:3.2:1:0.3, v/v/v/v), and cyclohexane: toluene: diethylamine (7:1.5:1.5, v/v/v) with one drop of 25% ammonia solution were used as mobile phases. The compatibility of the three drugs in their respective TPN admixtures was then assessed at various time points over a 24 h period using these HPTLC methods. Each drug admixed in TPN was directly applied onto the HPTLC plates without further sample pre-treatment. Paired Two-One-Sided Test (TOST) equivalent testing revealed that the concentrations of the selected drugs in TPN were unchanged over the monitoring period (p > 0.05), confirming chemical compatibility. These findings were in line with previous studies that concluded compatibility and reported similar R(F) and LOD/LOQ values (1.95/5.90 ng/band for caffeine, 252.22/764.30 ng/band for ibuprofen and 10.82/32.78 ng/band for midazolam; R(2) >/= 0.99). As no additional sample pre-treatment was required, HPTLC-based compatibility studies of drug-TPN admixtures may simplify the analytical workflow, making them a cost-effective and time-efficient approach to compatibility testing. FAU - Sikdar, K M Yasif Kayes AU - Sikdar KMYK AUID- ORCID: 0000-0003-4958-2745 AD - Department of Pharmacy and Centre for Optimisation of Medicines, School of Health and Clinical Sciences, University of Western Australia, Perth, WA 6009, Australia. FAU - Islam, Md Khairul AU - Islam MK AUID- ORCID: 0000-0002-9333-6536 AD - Department of Pharmacy and Centre for Optimisation of Medicines, School of Health and Clinical Sciences, University of Western Australia, Perth, WA 6009, Australia. FAU - Sostaric, Tomislav AU - Sostaric T AUID- ORCID: 0000-0002-0154-4179 AD - Department of Pharmacy and Centre for Optimisation of Medicines, School of Health and Clinical Sciences, University of Western Australia, Perth, WA 6009, Australia. FAU - Lim, Lee Yong AU - Lim LY AUID- ORCID: 0000-0002-7307-0742 AD - Department of Pharmacy and Centre for Optimisation of Medicines, School of Health and Clinical Sciences, University of Western Australia, Perth, WA 6009, Australia. AD - Institute for Paediatric Perioperative Excellence, University of Western Australia, Perth, WA 6009, Australia. FAU - Femia, Marcus AU - Femia M AD - Pharmacy Department, Women and Newborn Health Service, King Edward Memorial Hospital, Subiaco, WA 6008, Australia. FAU - Locher, Cornelia AU - Locher C AUID- ORCID: 0000-0001-8773-3036 AD - Department of Pharmacy and Centre for Optimisation of Medicines, School of Health and Clinical Sciences, University of Western Australia, Perth, WA 6009, Australia. AD - Institute for Paediatric Perioperative Excellence, University of Western Australia, Perth, WA 6009, Australia. LA - eng PT - Journal Article DEP - 20260820 PL - Switzerland TA - Molecules JT - Molecules (Basel, Switzerland) JID - 100964009 RN - 3G6A5W338E (Caffeine) RN - R60L0SM5BC (Midazolam) RN - WK2XYI10QM (Ibuprofen) RN - U26EO4675Q (caffeine citrate) RN - 0 (Citrates) SB - IM MH - *Caffeine/analysis/chemistry MH - Chromatography, Thin Layer/methods MH - *Midazolam/analysis/chemistry MH - *Ibuprofen/analysis/chemistry MH - *Parenteral Nutrition, Total/methods MH - Humans MH - Citrates PMC - PMC13515485 OTO - NOTNLM OT - HPTLC OT - chemical compatibility OT - drug admixing OT - total parenteral nutrition (TPN) COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/20 CRDT- 2026/08/27 01:09 PHST- 2026/07/28 00:00 [received] PHST- 2026/08/15 00:00 [revised] PHST- 2026/08/18 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:09 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - molecules31162904 [pii] AID - molecules-31-02904 [pii] AID - 10.3390/molecules31162904 [doi] PST - epublish SO - Molecules. 2026 Aug 20;31(16):2904. doi: 10.3390/molecules31162904. PMID- 42652740 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 16 DP - 2026 Aug 16 TI - Return to Sport After Surgery for Adolescent Idiopathic Scoliosis: From Time-Based Clearance to Sport-Specific Readiness. LID - 10.3390/jcm15166336 [doi] LID - 6336 AB - Return to sport (RTS) is an important outcome after surgery for adolescent idiopathic scoliosis (AIS), yet postoperative clearance remains largely time-based and reported outcomes vary according to procedure, population, endpoint, and treating-center policy. This critical review integrates direct postoperative RTS cohorts with biomechanical, rehabilitation, psychological, safety, and clinical-guidance evidence. Most available data concern adolescents treated with posterior spinal fusion and rely on self-reported participation. Resumption of physical activity or sport is common within the first postoperative year, but return to the same discipline, previous competitive level, and objectively verified performance is less consistently demonstrated. Evidence for anterior fusion is sparse, whereas vertebral body tethering is supported by smaller, selected cohorts and should be interpreted separately. Associations between RTS and distal fusion level or construct characteristics remain inconsistent, and biomechanical studies suggest redistribution rather than normalization of movement. Reported sport-related complications are uncommon, but existing cohorts are too small and lack exposure denominators to quantify rare events. No universal safe date or validated AIS-specific readiness battery currently exists. The proposed Multidimensional Scoliosis Return-to-Sport Framework therefore uses elapsed time as safety context while integrating clinical recovery, physical and psychological readiness, graded sport-specific exposure, and distinct return outcomes. The framework is evidence-informed and requires prospective validation. FAU - May, Maria Cesarina AU - May MC AD - IRCCS Azienda Ospedaliera Metropolitana, 16132 Genoa, Italy. FAU - Biz, Carlo AU - Biz C AUID- ORCID: 0000-0001-8517-0057 AD - Department of Orthopedics and Orthopedic Oncology, Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padova, 35128 Padova, Italy. FAU - Puce, Luca AU - Puce L AUID- ORCID: 0000-0003-0825-2707 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, 16132 Genoa, Italy. FAU - Zanirato, Andrea AU - Zanirato A AUID- ORCID: 0000-0003-2578-1133 AD - IRCCS Azienda Ospedaliera Metropolitana, 16132 Genoa, Italy. AD - Department of Integrated Surgical Diagnostic Sciences (DISC), Orthopedic Clinic, University of Genoa, 16132 Genoa, Italy. FAU - Ruggieri, Pietro AU - Ruggieri P AUID- ORCID: 0000-0001-9617-9882 AD - Department of Orthopedics and Orthopedic Oncology, Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padova, 35128 Padova, Italy. FAU - Formica, Matteo AU - Formica M AD - IRCCS Azienda Ospedaliera Metropolitana, 16132 Genoa, Italy. AD - Department of Integrated Surgical Diagnostic Sciences (DISC), Orthopedic Clinic, University of Genoa, 16132 Genoa, Italy. LA - eng PT - Journal Article PT - Review DEP - 20260816 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13512920 OTO - NOTNLM OT - adolescent idiopathic scoliosis OT - athletic performance OT - posterior spinal fusion OT - psychological readiness OT - rehabilitation OT - return to sport OT - sports participation OT - vertebral body tethering COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/16 CRDT- 2026/08/27 01:06 PHST- 2026/07/22 00:00 [received] PHST- 2026/08/13 00:00 [revised] PHST- 2026/08/14 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:06 [entrez] PHST- 2026/08/16 00:00 [pmc-release] AID - jcm15166336 [pii] AID - jcm-15-06336 [pii] AID - 10.3390/jcm15166336 [doi] PST - epublish SO - J Clin Med. 2026 Aug 16;15(16):6336. doi: 10.3390/jcm15166336. PMID- 42652618 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 16 DP - 2026 Aug 11 TI - Artificial Intelligence for Personalized Prediction of Post-TIPS Outcomes: Integrating Clinical, Biochemical, and Radiomics Data-A Narrative Review. LID - 10.3390/jcm15166211 [doi] LID - 6211 AB - Transjugular intrahepatic portosystemic shunt (TIPS) is an established treatment for complications of portal hypertension, but hepatic encephalopathy (HE), liver dysfunction, rebleeding, and mortality remain difficult to predict in otherwise eligible candidates. However, predicting post-TIPS outcomes remains challenging using conventional risk scores such as MELD 3.0 and Child-Turcotte-Pugh. This narrative review critically evaluates how clinical, biochemical, procedural, conventional imaging, handcrafted radiomics, and deep-learning features can be integrated for personalized post-TIPS risk prediction, supplemented by backward and forward reference checking. Thirty-two original post-TIPS studies met the core inclusion criteria: 18 focused primarily on clinical, biochemical, hemodynamic, microbiome, or procedural predictors and 14 on imaging, body composition, radiomics, or multimodal models. AI, ML, and radiomics models, by the aim of logistic regression, tree-based ensembles, support vector machines, artificial neural networks, and hybrid deep-learning models, able to capture non-linear interactions, have consistently demonstrated improved predictive performance compared with conventional scores, particularly for HE, with reported incidences of approximately 20-47%, mortality, and liver dysfunction. Their advantage lies in the ability to model complex, non-linear relationships and integrate heterogeneous data sources, including laboratory parameters, ammonia levels, hemodynamic variables, and imaging-derived features. Radiomics and deep learning approaches further enhance predictive accuracy. CT is currently the principal imaging substrate, while direct post-TIPS radiomics evidence for MRI and ultrasound remains sparse. Studies of liver and spleen morphology, portal-vein geometry, muscle and adipose tissue, and radiomic texture suggest incremental information beyond conventional scores, particularly when clinical and imaging features are combined; however, negative volumetric findings show that additional image features do not automatically improve prediction. However, most studies are retrospective, single-center, and lack external validation and no validated transformer-based or other sequence model has yet been established for post-TIPS outcomes. Standardization issues in radiomics and limited model interpretability remain significant barriers. Future directions should lead to prospective multicenter cohort validation, increasing sample sizes, harmonized imaging and endpoint definitions, locked external validation with recalibration, and the development of clinically interpretable tools to make it easier to identify those patients suitable for TIPS and their post-procedural management. FAU - Barrancotto, Alessio AU - Barrancotto A AD - Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy. FAU - Di Cola, Simone AU - Di Cola S AUID- ORCID: 0000-0002-6414-4404 AD - Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy. FAU - Melandro, Fabio AU - Melandro F AUID- ORCID: 0000-0003-4056-9245 AD - Department of General Surgery and Surgical Specialties Paride Stefanini, Sapienza University of Rome, 00185 Rome, Italy. FAU - Lapenna, Lucia AU - Lapenna L AUID- ORCID: 0000-0002-6761-4969 AD - Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy. FAU - Vignone, Anthony AU - Vignone A AUID- ORCID: 0000-0001-6009-2398 AD - Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy. FAU - Bencivenga, Antonio AU - Bencivenga A AD - Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy. FAU - Brancati, Arianna AU - Brancati A AD - Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy. FAU - Lucatelli, Pierleone AU - Lucatelli P AUID- ORCID: 0000-0002-7448-1404 AD - Department of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, 00185 Rome, Italy. FAU - Corona, Mario AU - Corona M AD - Department of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, 00185 Rome, Italy. FAU - Gioia, Stefania AU - Gioia S AUID- ORCID: 0000-0002-3940-4390 AD - Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy. FAU - Nardelli, Silvia AU - Nardelli S AUID- ORCID: 0000-0002-7038-9539 AD - Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy. LA - eng PT - Journal Article PT - Review DEP - 20260811 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13513915 OTO - NOTNLM OT - TIPS OT - artificial intelligence OT - body composition OT - explainable AI OT - hepatic encephalopathy OT - machine learning OT - multimodal prediction OT - radiomics OT - risk prediction COIS- The authors declare no conflict of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/11 CRDT- 2026/08/27 01:06 PHST- 2026/07/03 00:00 [received] PHST- 2026/08/05 00:00 [revised] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:06 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - jcm15166211 [pii] AID - jcm-15-06211 [pii] AID - 10.3390/jcm15166211 [doi] PST - epublish SO - J Clin Med. 2026 Aug 11;15(16):6211. doi: 10.3390/jcm15166211. PMID- 42652559 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 16 DP - 2026 Aug 7 TI - Long-Term Coronary Outcomes and Follow-Up After Kawasaki Disease: Insights from a 25-Year Follow-Up Cohort. LID - 10.3390/jcm15166155 [doi] LID - 6155 AB - Introduction: Kawasaki disease (KD) is an acute systemic vasculitis and the leading cause of acquired pediatric heart disease in high-income countries. Coronary artery aneurysms (CAA) represent the most severe complication and drive long-term cardiovascular risk. Despite improved outcomes with early intravenous immunoglobulin therapy, follow-up strategies remain heterogeneous, particularly for patients showing CAA regression. Dynamic risk stratification based on coronary Z-scores has been proposed, but long-term real-world data are still needed to optimize surveillance. Methods: We conducted a single-center, retrospective study including pediatric patients (age 1 month-18 years) with KD complicated by CAA, followed at Bambino Gesu Children's Hospital (Rome) between 1999 and 2024. Coronary involvement was assessed using Boston Z-scores of the right coronary artery, left main coronary artery, and left anterior descending artery. CAA severity over time was analyzed using a composite MAX SCORE (highest Z-score among coronary branches) along with the 1-YEAR MAX SCORE (highest MAX SCORE reached within the 1 year of disease). The distribution and timing of cardiac computed tomography angiography (CCTA) and exercise stress testing (EST) during follow-up were analyzed in relation to coronary severity. Results: Among 502 KD patients, 122 (24.3%) developed CAA; 113 were included in the analysis. Mean age at diagnosis was 24.6 months (M/F 3.5:1). Multivessel involvement was observed in 72%, most frequently affecting the left anterior descending artery. Long-term follow-up >/=10 years was available for 31.9% of patients. Most changes in coronary severity occurred within the first year after disease onset, with complete CAA regression in 76.1% of patients. Conversely, 53% of patients affected by giant aneurysms at 12 months showed persistent severe disease at last follow-up. EST (164 tests in 40 patients) was almost universally negative for inducible ischemia (163/164), whereas CCTA (47 exams in 35 patients) was preferentially performed early and in higher-risk patients. Test prescription correlated more closely with 1-YEAR MAX SCORE than with contemporaneous severity. Echocardiography showed systematic differences compared with CCTA for right coronary and left anterior descending artery Z-scores. Discussion: In our experience, early coronary status was closely associated with the intensity of long-term surveillance strategies in KD. The 1-YEAR MAX SCORE was associated with subsequent patterns of coronary evolution, and the continuous 1-year Maximum Z-score showed good discriminatory ability for persistent CAA on ROC analysis, pending external validation. While the low rate of positive findings on EST raises questions about its diagnostic yield in real-world practice, CCTA provided detailed anatomical characterization. Overall, these findings suggest that early coronary severity may help inform individualized, severity-driven follow-up strategies, warranting confirmation in prospective multicenter studies. FAU - Musolino, Antonio AU - Musolino A AUID- ORCID: 0000-0002-3316-957X AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Marchesi, Alessandra AU - Marchesi A AUID- ORCID: 0000-0002-6802-934X AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Antonelli, Giovanni AU - Antonelli G AD - Clinical Cardiology Unit, Division of Cardiac Surgery, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Gargiullo, Livia AU - Gargiullo L AUID- ORCID: 0000-0003-0316-6359 AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Storelli, Flavio AU - Storelli F AD - Meyer Children's Hospital IRCCS, 50139 Florence, Italy. FAU - Orso, Giovanni AU - Orso G AD - Pediatric Emergency Department, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Benelli, Benedetta AU - Benelli B AD - School of Pediatrics, Tor Vergata University of Rome, 00133 Roma, Italy. FAU - Ventura, Marta AU - Ventura M AD - School of Pediatrics, Tor Vergata University of Rome, 00133 Roma, Italy. FAU - Ariaudo, Ludovica AU - Ariaudo L AD - Department of Sciences of Public Health and Pediatrics, University of Turin, 10124 Torino, Italy. FAU - Cafiero, Giulia AU - Cafiero G AUID- ORCID: 0000-0001-6180-9338 AD - Clinical Cardiology Unit, Division of Cardiac Surgery, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Calcagni, Giulio AU - Calcagni G AUID- ORCID: 0000-0003-3187-0829 AD - Clinical Cardiology Unit, Division of Cardiac Surgery, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Leonardi, Benedetta AU - Leonardi B AUID- ORCID: 0000-0001-6715-3472 AD - Clinical Cardiology Unit, Division of Cardiac Surgery, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Lioncino, Michele AU - Lioncino M AUID- ORCID: 0000-0003-0205-5235 AD - Clinical Cardiology Unit, Division of Cardiac Surgery, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Secinaro, Aurelio AU - Secinaro A AUID- ORCID: 0000-0002-2611-8061 AD - Advanced Cardiothoracic Imaging Unit, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. FAU - Babini, Riccardo AU - Babini R AUID- ORCID: 0000-0001-7896-8191 AD - Independent Data Analyst and Software Engineer, Via Armando Diaz 10, 20881 Bernareggio, Italy. FAU - Villani, Alberto AU - Villani A AUID- ORCID: 0000-0002-9120-0424 AD - General Pediatrics, Infectious Diseases and Level II Pediatric Emergency Department Unit, IRCCS Bambino Gesu Children's Hospital, 00165 Rome, Italy. LA - eng PT - Journal Article DEP - 20260807 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13513250 OTO - NOTNLM OT - Kawasaki disease OT - cardiac imaging OT - cardiac tomography OT - coronary Z-score OT - coronary artery aneurysms OT - exercise stress testing OT - long-term follow-up OT - pediatric cardiology COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/07 CRDT- 2026/08/27 01:06 PHST- 2026/05/29 00:00 [received] PHST- 2026/07/19 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:06 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - jcm15166155 [pii] AID - jcm-15-06155 [pii] AID - 10.3390/jcm15166155 [doi] PST - epublish SO - J Clin Med. 2026 Aug 7;15(16):6155. doi: 10.3390/jcm15166155. PMID- 42652543 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 16 DP - 2026 Aug 7 TI - Psychiatric and Psychosocial Outcomes of Bariatric Surgery in Adolescents and Adult Women: A Prospective Cohort Study. LID - 10.3390/jcm15166139 [doi] LID - 6139 AB - Background/Objectives: The rising prevalence of severe adolescent obesity has increased the number of young patients referred for bariatric surgery. The psychiatric and psychosocial profiles of adolescents and of adult women undergoing this treatment remain insufficiently characterized. This study compared preoperative and postoperative psychiatric, psychosocial, and metabolic profiles of adolescents and adult women undergoing bariatric surgery. Methods: This prospective cohort study recruited 77 consecutive female patients (32 adolescents aged <18 years; 45 adult women aged 18-25 years) at a single bariatric center in Poland between December 2022 and December 2023. All participants underwent comprehensive preoperative and one-year postoperative assessments including laboratory testing, standardized psychiatric interviews, and psychometric screening with the Beck Depression Inventory (BDI) and the Patient Health Questionnaire-9 (PHQ-9). Results: Preoperatively, adolescents were more severely affected for their age (median BMI-for-age z-score 3.53) and waited longer between the first obesity clinic visit and surgery. Adolescents more frequently reported self-harm behaviors and moderate-to-severe depression on the BDI, whereas adult women more often reported psychoactive substance use. Both groups achieved comparable improvements in laboratory and comorbidity outcomes at one year, although relative weight loss was greater in adult women (median total weight loss 37.6% vs. 28.4%, p < 0.0001). Postoperatively, a greater proportion of adolescents than adult women improved with respect to social anxiety (50.0% vs. 13.3%, p = 0.0007) and BDI depression severity (53.1% vs. 24.4%, p = 0.02), whereas a greater proportion of adult women improved with respect to psychoactive substance use (46.7% vs. 12.5%, p = 0.003). Generalized anxiety and suicidal ideation declined within both groups, but the extent of improvement did not differ significantly between them. These differences persisted, and for several outcomes became larger, after adjustment for the reduction in BMI, which was smaller in adolescents. Conclusions: In this observational cohort, bariatric surgery was associated with distinct psychiatric and psychosocial outcome profiles in adolescents compared with adult women. Because the study was uncontrolled and included no non-surgical comparison group, these findings are hypothesis-generating and cannot establish a causal effect of surgery or of its timing; confirmation in larger, multicenter studies with appropriate comparison groups is required. Comprehensive multidisciplinary perioperative care and tailored postoperative psychological support appear important for both age groups. FAU - Herstowska, Marta AU - Herstowska M AUID- ORCID: 0000-0002-0905-6233 AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Przygocka-Pieniazek, Ada AU - Przygocka-Pieniazek A AUID- ORCID: 0000-0001-7831-0242 AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Lejk, Agnieszka AU - Lejk A AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Burzynski, Jacek AU - Burzynski J AD - Department of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland. FAU - Mysliwiec, Malgorzata AU - Mysliwiec M AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Kaska, Lukasz AU - Kaska L AD - Hospital of the Ministry of the Interior and Administration, 80-104 Gdansk, Poland. LA - eng PT - Journal Article DEP - 20260807 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13513403 OTO - NOTNLM OT - adolescent obesity OT - bariatric surgery OT - depression OT - mental health OT - psychosocial outcomes COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/07 CRDT- 2026/08/27 01:06 PHST- 2026/06/25 00:00 [received] PHST- 2026/08/02 00:00 [revised] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:06 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - jcm15166139 [pii] AID - jcm-15-06139 [pii] AID - 10.3390/jcm15166139 [doi] PST - epublish SO - J Clin Med. 2026 Aug 7;15(16):6139. doi: 10.3390/jcm15166139. PMID- 42652044 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2227-9059 (Print) IS - 2227-9059 (Electronic) IS - 2227-9059 (Linking) VI - 14 IP - 8 DP - 2026 Jul 24 TI - Early-Life Biomarkers in Food Allergy Development: A Systematic Review of Immunological and Intestinal Pathways. LID - 10.3390/biomedicines14081661 [doi] LID - 1661 AB - Background: The increasing incidence of pediatric food allergy (FA) drives an imperative for mechanistically driven risk stratification beyond descriptive diagnostics. The current systematic review aims to assess the predictive and diagnostic value of early-life non-invasive biomarkers: cord blood IgE (CS-IgE), fecal calprotectin (FC), fecal zonulin (FZ) and secretory IgA (SIgA). Methods: In accordance with the PRISMA guidelines, we performed a systematic literature search on PubMed/MEDLINE and Scopus for English observational studies published in 2009-2025. The titles and abstracts were screened by two independent reviewers and methodological quality was assessed using the Newcastle-Ottawa Scale (NOS). Results: A total of 17 studies met the inclusion criteria. This synthesis demonstrates that CS-IgE reflects a systemic atopic predisposition rather than serving as a highly sensitive predictor for isolated FA. Fecal calprotectin was the most consistent marker of inflammatory activity in non-IgE-mediated food allergies, with median values in food allergy ranging from approximately 200 to 410 microg/g and proven useful in dietary monitoring. Fecal zonulin reflects epithelial barrier dysfunction; however, its clinical utility is limited by suboptimal assay specificity. SIgA primarily reflects mucosal immune maturation and tolerance development rather than serving as a direct diagnostic marker. Conclusions: Although CS-IgE, FC, FZ and SIgA exhibit potential in the risk stratification of early FA, their clinical implementation is complicated by methodological heterogeneity and concerns regarding analytical specificity, especially with respect to zonulin assays. We propose an integrated multi-biomarker risk stratification model as a conceptual hypothesis requiring prospective validation in future large-scale studies. FAU - Ivasko, Alina-Maria AU - Ivasko AM AD - George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Gheorghe Marinescu Street 38, 540142 Targu Mures, Mures, Romania. AD - Department of Internal Medicine, Emergency Clinical County Hospital of Targu Mures, Gheorghe Marinescu Street 50, 540136 Targu Mures, Mures, Romania. FAU - Ureche, Corina AU - Ureche C AUID- ORCID: 0000-0002-1235-9331 AD - George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Gheorghe Marinescu Street 38, 540142 Targu Mures, Mures, Romania. FAU - Marginean, Oana Cristina AU - Marginean OC AUID- ORCID: 0000-0003-2119-1726 AD - George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Gheorghe Marinescu Street 38, 540142 Targu Mures, Mures, Romania. FAU - Grama, Monica AU - Grama M AD - George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Gheorghe Marinescu Street 38, 540142 Targu Mures, Mures, Romania. FAU - Nicola-Varo, Teodora AU - Nicola-Varo T AD - George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Gheorghe Marinescu Street 38, 540142 Targu Mures, Mures, Romania. LA - eng PT - Journal Article PT - Review DEP - 20260724 PL - Switzerland TA - Biomedicines JT - Biomedicines JID - 101691304 PMC - PMC13509919 OTO - NOTNLM OT - cord blood IgE OT - fecal calprotectin OT - fecal zonulin OT - food allergy OT - predictive biomarkers OT - secretory IgA COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/07/24 CRDT- 2026/08/27 01:05 PHST- 2026/05/24 00:00 [received] PHST- 2026/07/07 00:00 [revised] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:05 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - biomedicines14081661 [pii] AID - biomedicines-14-01661 [pii] AID - 10.3390/biomedicines14081661 [doi] PST - epublish SO - Biomedicines. 2026 Jul 24;14(8):1661. doi: 10.3390/biomedicines14081661. PMID- 42651535 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 8 DP - 2026 Aug 7 TI - The Association Between Physical Activity and Physical Literacy Among Adolescents: A Cross-Sectional Study. LID - 10.3390/bs16081358 [doi] LID - 1358 AB - This study examined the association between physical activity (PA) patterns and physical literacy (PL) among adolescents in Shanghai, China. The researchers conducted a cross-sectional survey between December 2021 and February 2022. They recruited 1624 adolescents aged 11 to 18 from schools in various districts of Shanghai using stratified sampling. Out of these, 1500 provided complete and valid questionnaires for analysis. The researchers assessed PL using a validated adolescent Physical Literacy Questionnaire and measured PA with an updated PA questionnaire that included school-based, household, transportation, and leisure activities. The demographic factors considered included gender, school stage, academic performance, and family socioeconomic status (SES). Two-way multivariate analysis of variance (MANOVA) and multiple linear regression analyses were used to explore group differences and the connections between PA and PL. The MANOVA results showed significant differences in PA based on gender (F(1,1498) = 7.94, p < 0.001) and school stage (F(1,1498) = 9.79, p < 0.001). However, no significant differences were found concerning academic performance (F(1,1498) = 2.12, p = 0.081) or SES (F(1,1498) = 1.90, p = 0.072). On the other hand, PL varied significantly by school stage (F(1,1498) = 9.55, p < 0.001), academic performance (F(1,1498) = 8.84, p < 0.05), and SES (F(1,1498) = 7.94, p < 0.05), but not by gender (F(1,1498) = 1.90, p = 0.121). Furthermore, multiple regression analyses revealed that involvement in school-based, transportation, and leisure-time PA was positively associated with adolescents' PL, whereas household PA was not. These findings suggest that adolescents' participation in PA and their PL vary among different demographic groups. Additionally, different PA contexts are associated with varying degrees of PL development. Because of the cross-sectional nature of the study, these findings should be seen as associative rather than indicating a causal relationship. Programs that encourage participation in school-based, transportation, and leisure activities may help improve adolescents' physical literacy. FAU - Qian, Song AU - Qian S AD - School of Marxism, Shanghai University of Sport, No. 399, Changhai Road, Yangpu District, Shanghai 200438, China. FAU - Wang, Xuebin AU - Wang X AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai 200240, China. AD - Post-Doctoral Station of Sport Science, Fujian Normal University, Cangshan Campus, No. 8 Shangsan Road, Cangshan District, Fuzhou 350007, China. FAU - Dan, He AU - Dan H AD - School of Journalism and Communication, Shanghai University of Sport, No. 399, Changhai Road, Yangpu District, Shanghai 200438, China. FAU - Qin, Yuke AU - Qin Y AD - School of Education, City University of Macau, Avenida Padre Tomas Pereira, Taipa, Macau 999078, China. LA - eng GR - 22CTY011/National Social Science Fund Youth Projects/ GR - 2020ETY004/Shanghai Social Science Planning Youth Project/ GR - C2-2020012/Shanghai Education Science Research Projects/ PT - Journal Article DEP - 20260807 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13509980 OTO - NOTNLM OT - adolescents OT - household PA OT - moderate-to-vigorous PA OT - physical activity OT - physical literacy OT - school-based PA COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/07 CRDT- 2026/08/27 01:04 PHST- 2026/04/20 00:00 [received] PHST- 2026/07/07 00:00 [revised] PHST- 2026/07/25 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:04 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - bs16081358 [pii] AID - behavsci-16-01358 [pii] AID - 10.3390/bs16081358 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Aug 7;16(8):1358. doi: 10.3390/bs16081358. PMID- 42651521 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 8 DP - 2026 Aug 5 TI - An Active Approach to Behavior: Exergaming Bike Breaks for Students with Disabilities. LID - 10.3390/bs16081344 [doi] LID - 1344 AB - Many children, particularly those with disabilities, do not meet the recommended amount of physical activity per day, which can increase the likelihood of poor health outcomes. Beyond the potential health benefits, physical activity breaks are associated with increased academic engagement and decreased stereotypy and off-task behavior. It is important to increase periods of physical activity in naturalistic settings like schools. The purpose of this article is to describe two pilot studies that examined the feasibility of integrating exergaming bike breaks into daily school routines for students with disabilities. Across the studies, data were collected on physical fitness, mood, classroom behavior, and acceptability. In Study 1, 13 students ages 9-13 with autism participated in exergaming biking for 15 min, 3 days per week for 6 weeks. No significant differences were observed between ride and non-ride days for teacher-reported behaviors; however, researcher-observed disruptive behaviors were significantly lower on ride days. In Study 2, six students with disabilities ages 9-17 who had a behavior intervention plan participated in biking for 5 days per week for 10 weeks. There was a significant increase in the percentage of time students were on-task and a decrease in time students were reported to be disruptive based on teacher behavior reports. Physical fitness remained low following intervention. Overall, exergaming biking was an acceptable and engaging form of physical activity that can be integrated into students' daily routines. Use of the bikes was associated with some improvement in classroom behavior. We discuss implications for practice and recommendations for future research. FAU - Kupzyk, Sara AU - Kupzyk S AUID- ORCID: 0000-0002-6721-8659 AD - Department of Psychology, University of Nebraska at Omaha, Omaha, NE 68182, USA. FAU - Reelfs, Heidi K AU - Reelfs HK AD - Department of Physical Therapy, Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, NE 68106, USA. FAU - Kupzyk, Kevin AU - Kupzyk K AD - College of Nursing, University of Nebraska Medical Center, Omaha, NE 68198, USA. LA - eng GR - 2017/Munroe-Meyer Institute Guild Grant/ PT - Journal Article DEP - 20260805 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13509195 OTO - NOTNLM OT - exergaming OT - physical activity breaks OT - positive behavior intervention COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/05 CRDT- 2026/08/27 01:04 PHST- 2026/05/21 00:00 [received] PHST- 2026/07/24 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:04 [entrez] PHST- 2026/08/05 00:00 [pmc-release] AID - bs16081344 [pii] AID - behavsci-16-01344 [pii] AID - 10.3390/bs16081344 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Aug 5;16(8):1344. doi: 10.3390/bs16081344. PMID- 42651518 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 8 DP - 2026 Aug 4 TI - Beyond Screen Time: Parent-Adolescent Relationship as a Mediating Pathway Between Problematic Internet Use and Psychological Well-Being Among Malaysian Adolescents. LID - 10.3390/bs16081341 [doi] LID - 1341 AB - The construct of adolescent psychological well-being has long been a focus of both public discourse and scholarly inquiry. With the widespread adoption of the Internet, there have been growing concerns about adolescents' exposure to escalating online risks. Parental mediation has been hypothesised to facilitate the guidance and regulation of adolescents' Internet use. However, the specific mediating role of the parent-adolescent relationship in the association between problematic Internet use and psychological well-being has remained underexamined, a gap explored in the current study. Based on the theoretical underpinnings provided by Phase Three of Bronfenbrenner's Bioecological Model of Human Development, a cross-sectional survey using validated psychometric instruments was conducted, involving 1598 students (mean age 16.0 years; 51% female) from secondary schools in Selangor, Malaysia. For data analysis, inferential statistics and partial least squares-structural equation modelling (PLS-SEM) were used to examine the complex structural relationships among the variables. Mean scores for problematic Internet use and psychological well-being indicated moderate severity levels. SEM results indicated the negative influence of problematic Internet use on psychological well-being (beta = -0.104 *, p = 0.040) and parent-adolescent relationship (beta = -0.241 **, p < 0.001) and a significant positive influence of parent-adolescent relationship on psychological well-being (beta = 0.328 **, p < 0.001). Subsequent mediation analysis confirmed the partial mediating effect of parent-adolescent relationship (indirect association: beta = -0.079) on the relationship between problematic Internet use and psychological well-being among Malaysian adolescents. This was consistent with Bronfenbrenner's Bioecological Model of Human Development. Strengthening the parent-adolescent relationship could mitigate the adverse psychological effects of excessive Internet use. From a policy perspective, these findings supported the use of family-focused intervention as a strategy to address the adverse psychological effects of problematic Internet use among adolescents. FAU - Okafor-Emeagha, Ijeoma Miriam AU - Okafor-Emeagha IM AUID- ORCID: 0000-0003-2561-6680 AD - Faculty of Nursing Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia. FAU - Ramoo, Vimala AU - Ramoo V AUID- ORCID: 0000-0001-8506-7826 AD - School of Nursing, Faculty of Health Sciences, Nursing and Education, Mahsa University, Bandar Saujana Putra, Jenjarom 42610, Selangor, Malaysia. FAU - Marret, Mary Joseph AU - Marret MJ AUID- ORCID: 0000-0002-1739-8751 AD - Department of Pediatrics, Faculty of Medicine, Universiti Malaya, Kuala Lumpur 50603, Malaysia. FAU - Ling, Lee Wan AU - Ling LW AUID- ORCID: 0000-0002-5584-2905 AD - Faculty of Nursing Science, Universiti Malaya, Kuala Lumpur 50603, Malaysia. LA - eng PT - Journal Article DEP - 20260804 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13510131 OTO - NOTNLM OT - adolescence OT - parental mediation OT - problematic internet use OT - psychological well-being COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/04 CRDT- 2026/08/27 01:04 PHST- 2026/05/04 00:00 [received] PHST- 2026/07/19 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:04 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - bs16081341 [pii] AID - behavsci-16-01341 [pii] AID - 10.3390/bs16081341 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Aug 4;16(8):1341. doi: 10.3390/bs16081341. PMID- 42651483 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 8 DP - 2026 Aug 1 TI - Developing and Evaluating a Universal Primary School Body Image Program: An Uncontrolled Pilot Study of Butterfly Body Bright. LID - 10.3390/bs16081306 [doi] LID - 1306 AB - Body image develops during childhood, yet few universal programs address body dissatisfaction and disordered eating risk across the primary school years. This paper describes the development of Butterfly Body Bright, which is, to our knowledge, a world-first whole-of-school program promoting positive body image and healthy relationships with eating and physical activity across all primary school years. We also describe an uncontrolled pilot study that evaluated the feasibility, acceptability, and impact of components of the program, namely, online staff training and teacher-led lessons from three program themes. Lessons targeted appearance-based teasing, media literacy, body gratitude, and self-compassion. Participants were 12 teachers and 114 Grade 4 to 6 children in Australia, who received one of seven Body Bright lessons. Significant pre- to immediate post-program improvements emerged in state body satisfaction, body appreciation, confidence managing appearance-based teasing, and help-seeking intentions. Specific lessons improved media literacy and appearance comparison and, at a 3-to-7-week follow-up, trait body appreciation. Boys showed improvement in state body satisfaction, confidence managing appearance-based teasing, and appreciation of body functionality. Girls showed improvement in state body satisfaction and media literacy. Butterfly Body Bright showed some promising preliminary results, with small to large effects, and was deemed feasible and acceptable by teachers, supporting the need for a randomized controlled trial. FAU - Damiano, Stephanie R AU - Damiano SR AUID- ORCID: 0000-0001-7659-4413 AD - School of Psychology and Public Health, La Trobe University, Melbourne 3086, Australia. AD - Butterfly Foundation, Sydney 2065, Australia. FAU - Jarman, Hannah K AU - Jarman HK AUID- ORCID: 0000-0001-8225-4511 AD - School of Psychology, Deakin University, Geelong 3220, Australia. FAU - Paxton, Susan J AU - Paxton SJ AUID- ORCID: 0000-0002-8486-1996 AD - School of Psychology and Public Health, La Trobe University, Melbourne 3086, Australia. LA - eng GR - NA/FDC Construction & Fitout/ PT - Journal Article DEP - 20260801 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13509812 OTO - NOTNLM OT - body dissatisfaction OT - body image OT - children OT - prevention OT - school OT - teachers OT - universal COIS- The first author (SRD) serves as the Manager of Butterfly Body Bright at Butterfly Foundation, the organisation responsible for delivering the program evaluated in this study. The authors recognize this represents a competing interest and declare it accordingly. However, all authors affirm that this relationship has not influenced the collection, analysis, or interpretation of data, nor the presentation of results. To mitigate potential bias, data entry and statistical analyses were conducted independently by a university-based co-author (HKJ). All authors agree with the contents of this manuscript. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/01 CRDT- 2026/08/27 01:04 PHST- 2026/05/22 00:00 [received] PHST- 2026/07/21 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:04 [entrez] PHST- 2026/08/01 00:00 [pmc-release] AID - bs16081306 [pii] AID - behavsci-16-01306 [pii] AID - 10.3390/bs16081306 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Aug 1;16(8):1306. doi: 10.3390/bs16081306. PMID- 42650945 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 16 IP - 16 DP - 2026 Aug 12 TI - Association of Inflammatory and Nutritional Biomarkers in Children with Febrile Seizures: A Case-Control Study of NLR, PNI, and CAR. LID - 10.3390/diagnostics16162541 [doi] LID - 2541 AB - Background/Objectives: Febrile seizures (FS) are the most frequent seizure disorder in childhood. Growing evidence suggests that systemic inflammatory responses may contribute to FS pathogenesis. Easily accessible inflammatory markers derived from routine blood tests, including the neutrophil-to-lymphocyte ratio (NLR), prognostic nutritional index (PNI), and C-reactive protein-to-albumin ratio (CAR), have been investigated as potential indicators of inflammatory status. This study aimed to explore the association between these biomarkers and FS in children. Methods: The medical records of 401 children were retrospectively evaluated, including 200 patients diagnosed with FS and 201 age-matched controls without a history of seizures. Demographic data and laboratory parameters were obtained, and NLR, PNI, and CAR were calculated. Group comparisons were performed using appropriate statistical tests. Multivariable logistic regression was applied to determine independent factors associated with FS, and receiver operating characteristic (ROC) analysis was conducted to evaluate biomarker performance. Results: Compared with controls, children with FS had higher neutrophil counts, NLR, and CAR values, whereas lymphocyte counts and PNI values were lower (all p < 0.05). Male sex was more frequent in the FS group (62.5% vs. 47.8%, p = 0.004). In multivariable analysis, younger age, male sex, and increased NLR were independently associated with FS. However, CAR and PNI did not remain significant after adjustment. NLR showed the highest discriminative ability among the evaluated markers, although its diagnostic performance was limited (AUC = 0.647). Conclusions: NLR may reflect the inflammatory response associated with febrile seizures and could provide supportive clinical information. However, its moderate diagnostic accuracy prevents its use as a standalone diagnostic marker. Further studies are required to clarify its clinical utility. FAU - Perk, Peren AU - Perk P AD - Department of Pediatric Neurology, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Turkey. FAU - Gumus Sarac, Suheyla AU - Gumus Sarac S AD - Department of Pediatric Emergency, Bursa Dortcelik Children Hospital, Bursa 16120, Turkey. FAU - Sandikkaya, Ayse AU - Sandikkaya A AD - Department of Pediatric Neurology, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Turkey. FAU - Ekici Ibrahimoglu, Fulya Sibel AU - Ekici Ibrahimoglu FS AD - Department of Pediatric Neurology, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Turkey. FAU - Karadogan, Muhammed Talha AU - Karadogan MT AD - Department of Pediatric Rheumatology, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Turkey. FAU - Koc, Rahime AU - Koc R AUID- ORCID: 0000-0002-9927-1526 AD - Department of Pediatric Rheumatology, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Turkey. FAU - Havali, Cengiz AU - Havali C AUID- ORCID: 0000-0001-6275-0884 AD - Department of Pediatric Neurology, Istanbul Basaksehir Cam and Sakura City Hospital, Istanbul 34480, Turkey. LA - eng PT - Journal Article DEP - 20260812 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC13511628 OTO - NOTNLM OT - C-reactive protein-to-albumin ratio OT - febrile seizure OT - neutrophil-to-lymphocyte ratio OT - prognostic nutritional index COIS- The authors declare no conflict of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/12 CRDT- 2026/08/27 01:03 PHST- 2026/07/16 00:00 [received] PHST- 2026/08/08 00:00 [revised] PHST- 2026/08/09 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:03 [entrez] PHST- 2026/08/12 00:00 [pmc-release] AID - diagnostics16162541 [pii] AID - diagnostics-16-02541 [pii] AID - 10.3390/diagnostics16162541 [doi] PST - epublish SO - Diagnostics (Basel). 2026 Aug 12;16(16):2541. doi: 10.3390/diagnostics16162541. PMID- 42650934 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 16 IP - 16 DP - 2026 Aug 11 TI - Applying Artificial Intelligence to Childhood Obesity: T2DM and MASLD Risk Predictive Models. LID - 10.3390/diagnostics16162533 [doi] LID - 2533 AB - Pediatric obesity is a complex, multifactorial pandemic with serious early-onset comorbidities, including prediabetes, type 2 diabetes, metabolic dysfunction-associated steatotic liver disease (MASLD), and cardiovascular disorders. While lifestyle modifications and the Mediterranean diet remain primary interventions, artificial intelligence (AI) is emerging as a critical tool for early diagnosis and personalized management. This review evaluates the current role of AI in predicting and treating childhood obesity and its complications. A literature search was conducted on PubMed and Google Scholar for English-language articles published from 2015 onward. Search terms included combinations of keywords related to "obesity", "pediatric", "comorbidities" (e.g., MASLD, diabetes), and "artificial intelligence" (e.g., machine learning, deep learning, multi-omics). Eligible study types ranged from original articles to systematic reviews and clinical guidelines. By integrating multi-omic data (genome, epigenome, transcriptome, metabolome, microbiota) with socio-psychological metrics, AI can predict obesity risk and early complications. Machine learning (ML) and deep learning have successfully identified specific metabolites, gut flora alterations, neurological pathways, and metabolic SNPs linked to obesity susceptibility. Furthermore, ML-driven prognostic models enable risk assessment for MASLD or diabetes progression, while specialized software supports remote lifestyle monitoring and tailored dietary interventions. AI has the potential to revolutionize pediatric obesity management through precision medicine. However, challenges regarding data privacy, digital literacy, and equitable access persist. Because current evidence relies heavily on limited and heterogeneous pediatric datasets, large-scale, well-characterized, and externally validated cohorts are essential to establish the clinical applicability of AI models before routine implementation. FAU - Amitrano, Marianna AU - Amitrano M AD - Unit of Pediatrics and Neonatology, Hospital "San Giovanni di Dio", 80027 Frattamaggiore, Italy. FAU - Mondillo, Gianluca AU - Mondillo G AUID- ORCID: 0009-0000-7756-8145 AD - Department of Woman, Child and of General and Specialized Surgery, Universita Degli Studi Della Campania "Luigi Vanvitelli", 80138 Naples, Italy. FAU - Emiliano, Mario AU - Emiliano M AD - Unit of Pediatrics and Neonatology, Hospital "San Giovanni di Dio", 80027 Frattamaggiore, Italy. FAU - Santoro, Umberto Paolo AU - Santoro UP AD - Department of Public Health, University of Naples "Federico II", 80131 Naples, Italy. LA - eng PT - Journal Article PT - Review DEP - 20260811 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC13511550 OTO - NOTNLM OT - MASLD OT - artificial intelligence OT - childhood obesity OT - type 2 diabetes COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/11 CRDT- 2026/08/27 01:03 PHST- 2026/05/19 00:00 [received] PHST- 2026/07/25 00:00 [revised] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:03 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - diagnostics16162533 [pii] AID - diagnostics-16-02533 [pii] AID - 10.3390/diagnostics16162533 [doi] PST - epublish SO - Diagnostics (Basel). 2026 Aug 11;16(16):2533. doi: 10.3390/diagnostics16162533. PMID- 42650550 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2304-8158 (Print) IS - 2304-8158 (Electronic) IS - 2304-8158 (Linking) VI - 15 IP - 16 DP - 2026 Aug 16 TI - Occurrence of Pesticide Residues and Acute, Chronic, and Cumulative Dietary Risk Assessment in Mango (Mangifera indica L.) from Lower Northern Thailand. LID - 10.3390/foods15162856 [doi] LID - 2856 AB - Mango (Mangifera indica L.), particularly the 'Nam Dok Mai' cultivar, is an economically important fruit crop in Thailand and is widely produced in the Lower Northern Region for domestic consumption and export. However, pesticide residues in mango remain a major food safety concern because of their potential effects on consumer health and compliance with national and international maximum residue limits (MRLs). This study investigated pesticide residue contamination and assessed the dietary health risks associated with mango consumption among different age groups. A total of 255 composite mango samples were collected from production areas in Phichit, Phitsanulok, and Phetchabun provinces, Thailand. Pesticide residues were analyzed using a validated modified QuEChERS extraction method combined with gas chromatography-tandem mass spectrometry (GC-MS/MS). Multiple pesticide residues were frequently detected in the samples analyzed. Of the detected residues, 22 pesticides exceeded Thai MRL standards and 14 exceeded Codex Alimentarius MRLs. Dietary exposure was evaluated using acute and chronic hazard quotients (HQa and HQc) and cumulative hazard indices (HIa and HIc). The results showed that acute exposure to several insecticides, particularly carbofuran, lambda-cyhalothrin, and fenpropathrin, exceeded acceptable risk thresholds in all age groups. At the pesticide-class level, cumulative acute exposure to organophosphates, carbamates, and pyrethroids showed HIa values greater than 1 in several age groups, suggesting potential short-term health concerns, especially among children. In contrast, chronic exposure to individual pesticides and cumulative pesticide groups remained below the level of concern for all age groups, with HQc and HIc values below 1. These findings indicate that although long-term dietary risk from mango consumption is within acceptable levels, acute exposure to certain pesticide residues may pose non-negligible health risks. Continuous residue monitoring, stricter enforcement of good agricultural practices, and evidence-based risk management are essential to ensure mango safety and protect consumers. FAU - Boonthawee, Kanlayanee AU - Boonthawee K AUID- ORCID: 0009-0008-0144-8196 AD - Environmental, Occupational Health Sciences and NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. AD - School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. FAU - Tongchai, Phannika AU - Tongchai P AUID- ORCID: 0000-0002-4045-6534 AD - Environmental, Occupational Health Sciences and NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. FAU - Yana, Pichamon AU - Yana P AD - Environmental, Occupational Health Sciences and NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. AD - Office of Research Administration, Chiang Mai University, Chiang Mai 50200, Thailand. FAU - Jaitham, Udomsap AU - Jaitham U AUID- ORCID: 0009-0006-2554-7127 AD - Environmental, Occupational Health Sciences and NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. AD - School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. FAU - Jeeno, Peerapong AU - Jeeno P AUID- ORCID: 0000-0002-3757-8557 AD - Environmental, Occupational Health Sciences and NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. AD - School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. FAU - Lungmala, Nid AU - Lungmala N AUID- ORCID: 0009-0008-8947-1162 AD - Environmental, Occupational Health Sciences and NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. AD - School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. FAU - Yadoung, Sumed AU - Yadoung S AUID- ORCID: 0009-0000-5798-0132 AD - Environmental, Occupational Health Sciences and NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. AD - School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. FAU - Danmek, Khanchai AU - Danmek K AUID- ORCID: 0000-0002-2348-463X AD - School of Agriculture and Natural Resources, University of Phayao, Phayao 56000, Thailand. FAU - Treewannakul, Panamas AU - Treewannakul P AUID- ORCID: 0000-0002-1815-9349 AD - Faculty of Agriculture, Kasetsart University, Bangkok 20900, Thailand. FAU - Amekawa, Yuichiro AU - Amekawa Y AUID- ORCID: 0000-0003-0596-5242 AD - College of International Relations, Ritsumeikan University, Kyoto 603-8577, Japan. FAU - Hongsibsong, Surat AU - Hongsibsong S AUID- ORCID: 0000-0002-5510-5905 AD - Environmental, Occupational Health Sciences and NCD Center of Excellence, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. AD - School of Health Sciences Research, Research Institute for Health Sciences, Chiang Mai University, Chiang Mai 50200, Thailand. LA - eng GR - 036/2568/Research Institute for Health Sciences/ GR - 2275/2568/Thailand Science Research and Innovation Fund/ GR - 23K27014/Japan Society for the Promotion of Science (JSPS) KAKENHI/ PT - Journal Article DEP - 20260816 PL - Switzerland TA - Foods JT - Foods (Basel, Switzerland) JID - 101670569 PMC - PMC13512399 OTO - NOTNLM OT - GC-MS/MS OT - QuEChERS OT - dietary risk assessment OT - hazard index OT - mango OT - pesticide residues COIS- The authors declare no conflict of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/16 CRDT- 2026/08/27 01:02 PHST- 2026/07/13 00:00 [received] PHST- 2026/08/09 00:00 [revised] PHST- 2026/08/14 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:02 [entrez] PHST- 2026/08/16 00:00 [pmc-release] AID - foods15162856 [pii] AID - foods-15-02856 [pii] AID - 10.3390/foods15162856 [doi] PST - epublish SO - Foods. 2026 Aug 16;15(16):2856. doi: 10.3390/foods15162856. PMID- 42650538 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2304-8158 (Print) IS - 2304-8158 (Electronic) IS - 2304-8158 (Linking) VI - 15 IP - 16 DP - 2026 Aug 14 TI - Traceability and Health Risk Assessment in the Feed-Animal-Milk Chain: A Comparative Evaluation of Traditional and Industrial Dairy Systems in Romania. LID - 10.3390/foods15162844 [doi] LID - 2844 AB - Cow milk and dairy products may reflect environmental elemental inputs transferred through the feed-animal-milk chain. This study investigated the elemental traceability, regional differentiation, dairy processing effects, and dietary exposure associated with milk and dairy products from two contrasting Romanian dairy production systems: the traditional Vaideeni region and the industrial Ibanesti region. A total of 88 samples (water, feed, raw milk, and dairy products) were seasonally collected during 2024-2025 and analysed for trace elements, geochemical fingerprint elements, and macroelements using ICP-OES and atomic absorption spectrometry. The strongest regional elemental contrasts were observed in groundwater for V (Deltalog(10) = +1.30), U (+0.82), Sr (+0.61), and Mn (+0.60), but these differences were substantially attenuated during biological transfer. Nevertheless, Li, U, Sr, Mn, and Cu retained measurable regional differences in milk. Regional elemental contrasts within the feed indicated an important inverse relationship (Pearson r = -0.60, p = 0.018), whereas no significant correlation was found between water and milk (Pearson r = -0.19, p = 0.493), suggesting that the milk elemental patterns may be influenced by biological regulatory processes in addition to the environmental signatures. Dairy processing further modified the elemental distribution, with the trace elements showing increased redistribution compared to the macroelements, while the geochemical fingerprint elements preserved regional information. The dietary exposure estimates for Cd and Ni remained below the corresponding toxicological reference values, whereas the highest estimated Pb exposure from hard cheese reached 0.977 mug/kg body weight/day for children and 0.558 mug/kg body weight/day for adults, exceeding the EFSA BMDL(01) reference point. The results indicate that multielement fingerprinting may provide promising information for investigating elemental traceability and supporting dairy product authenticity assessment within the investigated production systems, although extensive geographical validation will be required before application as a general authentication tool. FAU - Zgavarogea, Ionela Ramona AU - Zgavarogea IR AUID- ORCID: 0000-0001-7997-0090 AD - National Research and Development Institute for Cryogenic and Isotopic Technologies-ICSI Ramnicu Valcea, 4th Uzinei Street, P.O. Box Raureni 7, 240050 Ramnicu Valcea, Romania. FAU - Paun, Nadia AU - Paun N AUID- ORCID: 0000-0002-9702-1494 AD - National Research and Development Institute for Cryogenic and Isotopic Technologies-ICSI Ramnicu Valcea, 4th Uzinei Street, P.O. Box Raureni 7, 240050 Ramnicu Valcea, Romania. FAU - Sandru, Claudia AU - Sandru C AUID- ORCID: 0000-0002-5168-7290 AD - National Research and Development Institute for Cryogenic and Isotopic Technologies-ICSI Ramnicu Valcea, 4th Uzinei Street, P.O. Box Raureni 7, 240050 Ramnicu Valcea, Romania. FAU - Niculescu, Violeta-Carolina AU - Niculescu VC AUID- ORCID: 0000-0002-0439-3265 AD - National Research and Development Institute for Cryogenic and Isotopic Technologies-ICSI Ramnicu Valcea, 4th Uzinei Street, P.O. Box Raureni 7, 240050 Ramnicu Valcea, Romania. FAU - Nasture, Ana Maria AU - Nasture AM AUID- ORCID: 0000-0003-0298-5774 AD - National Research and Development Institute for Cryogenic and Isotopic Technologies-ICSI Ramnicu Valcea, 4th Uzinei Street, P.O. Box Raureni 7, 240050 Ramnicu Valcea, Romania. AD - DAIC SYSTEM S.R.L., 58 Fantanii Street, 240301 Ramnicu Valcea, Romania. FAU - Miricioiu, Marius-Gheorghe AU - Miricioiu MG AUID- ORCID: 0000-0002-0080-6595 AD - National Research and Development Institute for Cryogenic and Isotopic Technologies-ICSI Ramnicu Valcea, 4th Uzinei Street, P.O. Box Raureni 7, 240050 Ramnicu Valcea, Romania. LA - eng GR - NUCLEU Program-Financing Contract no. 20N/05.01.2023, Project PN 23 15 03 01/Romanian Ministry of Education and Research/ GR - NUCLEU Program-Financing Contract no. 20N/05.01.2023, Project PN 23 15 03 02/Romanian Ministry of Education and Research/ PT - Journal Article DEP - 20260814 PL - Switzerland TA - Foods JT - Foods (Basel, Switzerland) JID - 101670569 PMC - PMC13512816 OTO - NOTNLM OT - ICP-OES OT - dairy processing OT - environmental exposure OT - food authenticity OT - geochemical fingerprinting OT - regional traceability COIS- Author Ana Maria Nasture was employed by the company DAIC SYSTEM S.R.L. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/14 CRDT- 2026/08/27 01:02 PHST- 2026/06/23 00:00 [received] PHST- 2026/08/10 00:00 [revised] PHST- 2026/08/12 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:02 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - foods15162844 [pii] AID - foods-15-02844 [pii] AID - 10.3390/foods15162844 [doi] PST - epublish SO - Foods. 2026 Aug 14;15(16):2844. doi: 10.3390/foods15162844. PMID- 42650452 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 8 DP - 2026 Aug 20 TI - AI-Enabled Physical Activity Intervention Strategies for Children and Adolescents: A Scoping Review. LID - 10.3390/children13081114 [doi] LID - 1114 AB - BACKGROUND/OBJECTIVES: Most children and adolescents do not meet recommended physical activity (PA) levels. Artificial intelligence (AI) may enable personalized and adaptive interventions, but evidence across delivery formats remains unclear. This scoping review mapped AI-enabled PA interventions for children and adolescents aged 6-18 years. METHODS: Following PRISMA-ScR and Joanna Briggs Institute guidance, six databases were searched on 24 May 2026 for English-language studies published since 2018. Eligible studies used AI in intervention delivery and empirically evaluated at least one participant-level PA-related outcome following exposure to the intervention. The review protocol was registered during data analysis. RESULTS: Seven studies published between 2022 and 2026 were included. Primary AI techniques were computer vision (n = 3), generative AI or large language models (n = 2), reinforcement learning (n = 1), and evolutionary computation (n = 1). Interventions included immersive systems (n = 2), conversational agents (n = 2), exergames or serious games (n = 2), and a robot (n = 1). Three studies used controlled designs and four were single-arm pilot or feasibility studies. CONCLUSIONS: AI supported movement recognition, content generation, personalization, and adaptive feedback. However, the small, heterogeneous, and predominantly early-stage evidence base precludes conclusions about effectiveness. Rigorous controlled studies and transparent AI-specific reporting are needed. FAU - Zhao, Junling AU - Zhao J AUID- ORCID: 0009-0007-8734-0444 AD - School of Public Health, Peking University, Beijing 100191, China. AD - China Center for Health Development Studies, Peking University, Beijing 100191, China. FAU - Huang, Jiandong AU - Huang J AD - School of Control and Computer Engineering, North China Electric Power University, Beijing 102206, China. FAU - Shang, Zhaoyang AU - Shang Z AD - Department of Applied Mathematics and Informatics, Shenzhen MSU-BIT University, Shenzhen 518172, China. FAU - He, Zhongkai AU - He Z AD - Department of Physical Education, Peking University, Beijing 100871, China. LA - eng PT - Journal Article PT - Review DEP - 20260820 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13510757 OTO - NOTNLM OT - adolescents OT - artificial intelligence OT - children OT - machine learning OT - physical activity OT - scoping review OT - sedentary behaviour COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/20 CRDT- 2026/08/27 01:02 PHST- 2026/06/20 00:00 [received] PHST- 2026/08/13 00:00 [revised] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:02 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - children13081114 [pii] AID - children-13-01114 [pii] AID - 10.3390/children13081114 [doi] PST - epublish SO - Children (Basel). 2026 Aug 20;13(8):1114. doi: 10.3390/children13081114. PMID- 42650439 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 8 DP - 2026 Aug 18 TI - Exploratory Biological Correlates of Cognitive and Language Performance in Healthy Pubertal Children: A Retrospective Cross-Sectional Study. LID - 10.3390/children13081101 [doi] LID - 1101 AB - Background/Objectives: Adolescence is a dynamic neurodevelopmental period during which structured language performance may reflect ongoing biological reorganization processes. This study examined whether inflammatory, nutritional, and hormonal biomarkers were modestly associated with structured language task performance and cognitive performance in healthy pubertal children. Methods: A total of 156 healthy pubertal children (78 female, 78 male; mean age of 11.84 +/- 2.98 years) meeting Tanner Stage >/= 2 were included in this retrospective cross-sectional study. Language was assessed with the Test of Language Development-Primary: Fourth Edition (TOLD-P:4; Turkish adaptation) and cognition with the Wechsler Intelligence Scale for Children-Revised (WISC-R). Pan-Immune-Inflammation Value (PIV), Prognostic Nutritional Index (PNI), Neutrophil-to-Lymphocyte Ratio (NLR), vitamin B12, 25-OH vitamin D, ferritin, and TSH were included as biomarkers. Two-block hierarchical OLS regression and Spearman correlations with Benjamini-Hochberg FDR correction were used. Results: The biomarker block provided a statistically significant incremental contribution to the spoken language model (DeltaR(2) = 0.066, p = 0.041; full model R(2) = 0.287). The primary test statistic was DeltaR(2). In exploratory coefficient-level analyses that were not corrected for multiple comparisons, the PIV (beta = +0.17, p = 0.033) and TSH (beta = -0.17, p = 0.031) coefficients reached nominal significance. After FDR correction, PIV was positively associated with WISC-R Verbal score (rho = +0.24, p_FDR = 0.019) and TSH negatively with TOLD-P:4 Speaking (rho = -0.22, p_FDR = 0.029). Biomarker contribution to WISC-R Full-Scale IQ was non-significant (DeltaR(2) = 0.049, p = 0.223). Conclusions: At the block level, the biomarker set contributed significantly to the structured spoken-language model but not to the Full-Scale IQ model; however, one of the two FDR-significant bivariate associations involved a verbal cognitive measure (PIV with WISC-R Verbal). Any language-versus-cognition contrast should therefore be interpreted cautiously. The modest effect sizes suggest these relationships are best interpreted within a developmental and neuroimmune framework. Longitudinal and multimodal studies are needed to replicate these findings. Because the TOLD-P:4/TODIL was applied beyond its validated age range (4; 0-8; 11) and its cross-age scoring could not be verified from the retrospective records, all language-based findings are exploratory and require confirmation with an age-validated instrument; the study's confirmatory finding is the FDR-significant association of PIV with age-appropriate WISC-R Verbal performance. Because the TOLD-P:4/TODIL composite scores could not be verified as comparable across the sample's age range, all TOLD-P:4-based results reported here are exploratory and hypothesis-generating; the confirmatory analyses rely on the age-appropriate WISC-R outcomes. FAU - Savas, Merve AU - Savas M AUID- ORCID: 0000-0002-7138-2603 AD - Department of Speech and Language Therapy, Faculty of Health Sciences, Istanbul Atlas University, 34403 Istanbul, Turkiye. FAU - Kahraman Begen, Senanur AU - Kahraman Begen S AUID- ORCID: 0000-0001-6938-301X AD - Department of Speech and Language Therapy, Faculty of Health Sciences, Istanbul Atlas University, 34403 Istanbul, Turkiye. FAU - Okuyan, Omer AU - Okuyan O AUID- ORCID: 0009-0006-6364-8615 AD - Department of Pediatrics, Faculty of Medicine, Istanbul Atlas University, 34403 Istanbul, Turkiye. FAU - Uzun, Hafize AU - Uzun H AUID- ORCID: 0000-0002-1347-8498 AD - Department of Medical Biochemistry, Faculty of Medicine, Istanbul Atlas University, 34403 Istanbul, Turkiye. LA - eng PT - Journal Article DEP - 20260818 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13511123 OTO - NOTNLM OT - children OT - cognitive performance OT - language development OT - neurodevelopment OT - puberty COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/18 CRDT- 2026/08/27 01:02 PHST- 2026/05/20 00:00 [received] PHST- 2026/07/29 00:00 [revised] PHST- 2026/08/13 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:02 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - children13081101 [pii] AID - children-13-01101 [pii] AID - 10.3390/children13081101 [doi] PST - epublish SO - Children (Basel). 2026 Aug 18;13(8):1101. doi: 10.3390/children13081101. PMID- 42650436 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 8 DP - 2026 Aug 18 TI - Ratio That Reveals Risk: Defining TG:HDL-C Ratio Cutoff for Insulin Resistance in Adolescents with Obesity. LID - 10.3390/children13081098 [doi] LID - 1098 AB - Background/Objectives: Insulin resistance (IR) plays a central role in metabolic dysfunction and elevates the risk of chronic diseases such as type 2 diabetes mellitus in later life. Early identification of IR in adolescents is therefore important. This study aimed to determine the triglyceride-to-high-density lipoprotein cholesterol (TG:HDL-C) ratio cutoff for IR and assess its association with IR predictors among adolescents with obesity. Methods: A total of 215 blood samples from adolescents aged 13-16 years with obesity were analyzed for fasting blood glucose, lipids, insulin, leptin, and adiponectin. Obesity was defined using BMI z-scores, while IR was classified using the Homeostatic Model Assessment for Insulin Resistance (HOMA-IR >/= 4.0). Receiver operating characteristic (ROC) analysis was performed to compare the discriminatory performance between the TG:HDL-C ratio and Leptin:Adiponectin ratio (LAR). Multiple logistic regression was performed to assess associations between the TG:HDL-C ratio and IR-related markers. Results: The area under the ROC curve for the TG:HDL-C ratio was comparable to LAR (0.73 vs. 0.68, p = 0.3). The optimal TG:HDL-C ratio cutoff identified using the maximum Youden index was 0.89, with 62% sensitivity and 75% specificity. A TG:HDL-C ratio >/= 0.89 was associated with higher odds of elevated insulin (AOR 1.1, 95% CI 1.0-1.13), elevated HbA1c (AOR 2.7, 95% CI 1.1-6.6), abdominal obesity (AOR 3.6, 95% CI 1.9-6.7), and raised LAR (AOR 1.2, 95% CI 1.0-1.5). Conclusions: These findings suggest that a TG:HDL-C ratio cutoff of 0.89 may be a useful marker for identifying IR in adolescents with obesity. FAU - Iwani, Ahmad Kamil Nur Zati AU - Iwani AKNZ AUID- ORCID: 0009-0005-7376-4735 AD - Endocrine and Metabolic Unit, Nutrition, Metabolic, and Cardiovascular Research Center, Institute for Medical Research, National Institute of Health, Ministry of Health Malaysia, Setia Alam 40170, Malaysia. FAU - Jalaludin, Muhammad Yazid AU - Jalaludin MY AUID- ORCID: 0000-0003-4513-8444 AD - Department of Paediatrics, Faculty of Medicine, University Malaya, Kuala Lumpur 50603, Malaysia. FAU - Yahya, Abqariyah AU - Yahya A AD - Department of Social and Preventive Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur 50603, Malaysia. FAU - Abdullah, Shazana Rifham AU - Abdullah SR AD - Endocrine and Metabolic Unit, Nutrition, Metabolic, and Cardiovascular Research Center, Institute for Medical Research, National Institute of Health, Ministry of Health Malaysia, Setia Alam 40170, Malaysia. FAU - Ahmad Zamri, Liyana AU - Ahmad Zamri L AUID- ORCID: 0000-0003-0306-4897 AD - Endocrine and Metabolic Unit, Nutrition, Metabolic, and Cardiovascular Research Center, Institute for Medical Research, National Institute of Health, Ministry of Health Malaysia, Setia Alam 40170, Malaysia. FAU - Mansor, Fazliana AU - Mansor F AD - Endocrine and Metabolic Unit, Nutrition, Metabolic, and Cardiovascular Research Center, Institute for Medical Research, National Institute of Health, Ministry of Health Malaysia, Setia Alam 40170, Malaysia. FAU - Hong, Janet Yeow Hua AU - Hong JYH AD - Department of Paediatrics, Hospital Putrajaya, Ministry of Health Malaysia, Putrajaya 62250, Malaysia. FAU - Mokhtar, Abdul Halim AU - Mokhtar AH AUID- ORCID: 0000-0001-8057-313X AD - Department of Sports Medicine, Faculty of Medicine, University Malaya, Kuala Lumpur 50603, Malaysia. LA - eng GR - NMRR-18-2749-41841/MINISTRY OF HEALTH MALAYSIA/ PT - Journal Article DEP - 20260818 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13511121 OTO - NOTNLM OT - TG:HDL-C ratio OT - adolescents OT - cutoff OT - insulin resistance OT - obesity COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/18 CRDT- 2026/08/27 01:02 PHST- 2026/05/25 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:02 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - children13081098 [pii] AID - children-13-01098 [pii] AID - 10.3390/children13081098 [doi] PST - epublish SO - Children (Basel). 2026 Aug 18;13(8):1098. doi: 10.3390/children13081098. PMID- 42650380 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 8 DP - 2026 Aug 5 TI - Machine Learning-Based Prediction of Six-Minute Walk Distance in Children with Obesity. LID - 10.3390/children13081043 [doi] LID - 1043 AB - Background: The six-minute walk test (6MWT) assesses functional exercise capacity, but existing reference equations for children with obesity rely on traditional linear regression, potentially overlooking complex, non-linear relationships between anthropometric characteristics and functional exercise capacity. Objective: This study aimed to develop and internally validate machine-learning (ML) prediction models and preliminary prediction equations derived from explainable ML models for six-minute walk distance (6MWD) in Tunisian school-aged children with obesity and to compare their predictive performance with a conventional regression-based approach. Methods: We analyzed data from 236 school-aged children with obesity (104 females, 132 males; 6-12 years). Anthropometric measurements included body mass (BM), height, body mass index (BMI), waist circumference (WC), and hip circumference (HC). Five models were evaluated: linear regression, Ridge, Lasso, Elastic Net, and XGBoost. Performance was assessed using five-fold cross-validation and evaluated by the mean absolute error (MAE) and root mean square error (RMSE). Predictor importance was assessed using SHapley Additive exPlanation (SHAP) and Gini importance. Results: XGBoost achieved the best predictive performance, with the lowest MAE (17.4 +/- 2.5 m in females and 19.5 +/- 1.9 m in males) and RMSE (25.3 +/- 3.1 m in females and 26.4 +/- 2.2 m in males). Age was the strongest predictor across all models (SHAP: 54.2-62.0%; Gini importance: 0.52-0.69), followed by height and BMI. Sex-specific analyses indicated that, in females, age and BMI contributed ~80% to the cumulative SHAP analysis; whereas, in males, age, height, and WC were the primary factors. Conclusions: ML, particularly XGBoost, significantly improves 6MWD prediction in school-aged children with obesity compared with traditional linear regression. Explainable ML increases model interpretability by evaluating the relative importance of anthropometric predictors. These obesity-specific prediction models may better capture complex non-linear associations between anthropometrics and functional exercise capacity. These initial population-specific models should be validated in larger independent samples before routine use clinical or field settings. FAU - Makni, Emna AU - Makni E AUID- ORCID: 0009-0001-2941-1095 AD - Research Laboratory of Exercise Physiology and Pathophysiology (LR19ES09), Faculty of Medicine Ibn Al-Jazzar, University of Sousse, Sousse 4002, Tunisia. FAU - Elloumi, Mohamed AU - Elloumi M AUID- ORCID: 0000-0003-3751-2125 AD - Sport Sciences and Diagnostics Research Group, College of Sciences and Humanities, Prince Sultan University, Riyadh 11586, Saudi Arabia. FAU - Ammar, Achraf AU - Ammar A AUID- ORCID: 0000-0003-0347-8053 AD - Department of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, 55122 Mainz, Germany. AD - Research Laboratory, Molecular Bases of Human Pathology (LR19ES13), Faculty of Medicine of Sfax, University of Sfax, Sfax 3000, Tunisia. AD - Department of Nutrition and Food Technology, School of Agriculture, The University of Jordan, Amman 11942, Jordan. FAU - Brahim, Mehdi Ben AU - Brahim MB AUID- ORCID: 0000-0001-8439-0429 AD - Sport Sciences and Diagnostics Research Group, College of Sciences and Humanities, Prince Sultan University, Riyadh 11586, Saudi Arabia. FAU - Hachana, Younes AU - Hachana Y AD - Research Laboratory (LR23JS01) "Sport Performance, Health & Society", Higher Institute of Sport and Physical Education of Ksar Said, University of "La Manouba", Manouba 2037, Tunisia. LA - eng PT - Journal Article DEP - 20260805 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13511065 OTO - NOTNLM OT - anthropometry OT - explainable artificial intelligence OT - functional exercise capacity OT - pediatric obesity OT - predictive modelling COIS- The authors declare no conflicts of interest. EDAT- 2026/08/27 05:35 MHDA- 2026/08/27 05:36 PMCR- 2026/08/05 CRDT- 2026/08/27 01:02 PHST- 2026/07/03 00:00 [received] PHST- 2026/07/24 00:00 [revised] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/08/27 05:36 [medline] PHST- 2026/08/27 05:35 [pubmed] PHST- 2026/08/27 01:02 [entrez] PHST- 2026/08/05 00:00 [pmc-release] AID - children13081043 [pii] AID - children-13-01043 [pii] AID - 10.3390/children13081043 [doi] PST - epublish SO - Children (Basel). 2026 Aug 5;13(8):1043. doi: 10.3390/children13081043. PMID- 42650315 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 8 DP - 2026 Jul 23 TI - Biochemical and Inflammatory Profiles in Paediatric Obesity, Undernutrition and Normal Weight: A Single-Centre Retrospective Cohort Study. LID - 10.3390/children13080975 [doi] LID - 975 AB - Background: We compared biochemical, micronutrient-related and complete blood count (CBC)-derived inflammatory profiles among children with obesity, undernutrition and normal weight, and explored the discriminatory performance of selected routine laboratory markers for the obesity phenotype. Methods: In this single-centre retrospective comparative study, medical records of children aged 2-17 years evaluated between January 2023 and December 2025 were reviewed. Participants were classified as obese, undernourished or normal weight using World Health Organization (WHO) body mass index-for-age (BMI-for-age) references. Liver enzymes, lipid parameters, iron-related indices, micronutrient levels, zinc, insulin and CBC-derived inflammatory indices were compared across groups using non-parametric omnibus tests. Exploratory receiver operating characteristic (ROC) analyses were performed for selected markers. Results: A total of 690 children were included: 100 with obesity, 90 with undernutrition and 500 with normal weight. The obesity group was significantly older than the normal-weight group (median 11.0 vs. 7.5 years; p < 0.001). Obesity was characterised by higher alanine aminotransferase (ALT), insulin, triglycerides, neutrophil-to-lymphocyte ratio (NLR), systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI), together with lower high-density lipoprotein (HDL) cholesterol, 25-hydroxyvitamin D [25(OH)D] and aspartate aminotransferase-to-alanine aminotransferase (AST/ALT) ratio (all p < 0.05). In exploratory, age-unadjusted ROC analyses, the AST/ALT ratio yielded the highest AUC among the evaluated biomarkers (AUC 0.859; 95% CI 0.823-0.895; optimal cut-off /=15 y) from 45 surveys in 26 countries accessed from the FAO/WHO Global Individual Food Consumption Data Tool were analyzed. Multilevel linear and modified Poisson regression models quantified associations between PHDI, FGDS, GDQS+, and GDQS- with reference measures [e.g., mean adequacy ratio (MAR), % energy from ultraprocessed food (UPF)] or indicators of a healthy diet [e.g., >/=400 g/d of fruits and vegetables (F&V)], respectively. RESULTS: Adherence to PHDI was highest in low income (LIC) and lower-middle income countries (LMIC), and lowest in upper-middle income (UMIC) and high income countries (HIC). One-SD increments in PHDI were associated with higher MAR beta: 5.49 percentage points [pp]; [95% confidence interval (CI): 3.65 pp, 7.33 pp] in LIC to beta: 1.41 pp [95% CI: 1.23 pp, 1.58 pp] in UMIC, appropriate F&V intakes [relative risk (RR): 2.41 (95% CI: 1.85, 2.49) in UMIC to RR: 1.19 (95% CI: 1.05, 1.34) in LMIC], lower unprocessed red meat [beta: -10.0 g/d (95% CI: -11.4 g/d, -8.73 g/d) in LIC to beta: -6.86 g/d (95% CI: -7.54 g/d, -6.17 g/d) in UMIC], and lower proportions of energy from UPF [beta: -2.47 pp (95% CI: -3.77 pp, -1.18 pp) in LMIC to beta: -1.21 pp (95% CI: -2.32 pp, 0.105 pp) in LIC]; however, 1-SD increases in FGDS and GDQS+ outperformed PHDI in predicting measures of nutrient adequacy, particularly MAR [beta for FGDS: 11.2 pp (95% CI: 9.13 pp, 13.3 pp) in LIC to beta for FGDS: 8.57 pp (95% CI: 8.42 pp, 8.72 pp) in UMIC; beta for GDQS+: 9.82 pp (95% CI: 7.26 pp, 12.4 pp) in LMIC to beta for GDQS+: 7.18 pp (95% CI: 6.00 pp, 8.36 pp) in HIC] and appropriate F&V intakes [RR for FGDS: 2.78 (95% CI: 2.26, 3.41) in LMIC to RR for FGDS: 1.63 (95% CI: 1.22, 2.19) in HIC; RR for GDQS+: 2.39 (95% CI: 1.89, 2.89) in LMIC to RR for GDQS+: 1.55 (95% CI: 1.16, 1.96) in LIC]. CONCLUSIONS: PHDI may serve as a robust, dual-purpose measure for monitoring adherence to diets that are both sustainable and healthy in contexts with regular quantitative dietary intake assessments and low burdens of diet-related undernutrition. However, simpler food group-based measures, such as the FGDS, often show stronger associations with healthy diet subconstructs, such as nutrient adequacy, and are more feasible for large-scale, routine monitoring of diets. CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Hanley-Cook, Giles T AU - Hanley-Cook GT AD - Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium. Electronic address: giles.hanleycook@ugent.be. FAU - van der Meulen, Emma AU - van der Meulen E AD - Department of Food Technology, Safety and Health, Faculty of Bioscience Engineering, Ghent University, Ghent, Belgium. FAU - Beal, Ty AU - Beal T AD - Global Alliance for Improved Nutrition, Washington, DC, United States. FAU - Cacau, Leandro Teixeira AU - Cacau LT AD - Department of Nutrition, School of Public Health, University of Sao Paulo, Sao Paulo, Brazil; Center for Epidemiological Research in Nutrition and Health, University of Sao Paulo, Sao Paulo, Brazil. LA - eng PT - Journal Article PT - Validation Study DEP - 20260826 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - Female MH - *Diet, Healthy MH - Male MH - Cross-Sectional Studies MH - World Health Organization MH - Adult MH - Adolescent MH - Diet Records MH - Young Adult MH - Global Health MH - *Diet Surveys MH - Middle Aged MH - Diet MH - Energy Intake MH - Feeding Behavior OTO - NOTNLM OT - GDQS OT - MDD-W OT - Planetary Health Diet OT - dietary diversity OT - fruit and vegetable intake OT - moderation OT - nutrient adequacy OT - ultraprocessed foods OT - unprocessed red meat COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/08/26 23:35 MHDA- 2026/10/05 23:29 CRDT- 2026/08/26 19:15 PHST- 2025/11/08 00:00 [received] PHST- 2026/08/07 00:00 [revised] PHST- 2026/08/21 00:00 [accepted] PHST- 2026/10/05 23:29 [medline] PHST- 2026/08/26 23:35 [pubmed] PHST- 2026/08/26 19:15 [entrez] AID - S0002-9165(26)00304-7 [pii] AID - 10.1016/j.ajcnut.2026.101495 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Oct;124(4):101495. doi: 10.1016/j.ajcnut.2026.101495. Epub 2026 Aug 26. PMID- 42648534 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261015 IS - 1873-6424 (Electronic) IS - 0269-7491 (Linking) VI - 409 DP - 2026 Nov 15 TI - Quantitative decoupling of source-pathway-receptor driving mechanisms for integrated soil risk via interpretable machine learning. PG - 129052 LID - S0269-7491(26)01422-3 [pii] LID - 10.1016/j.envpol.2026.129052 [doi] AB - Most existing concentration-based risk assessments of potentially toxic elements (PTEs) in farmland soils tend to overlook source-specific transport pathways and receptor-related risks. In this study, an integrated risk index-machine learning framework based on the source-pathway-receptor concept is developed to comprehensively evaluate PTE risks in a typical mining city. The framework integrates the improved Nemerow index (INI), potential ecological risk index, Monte Carlo simulation-based health risk assessment, and machine learning models to identify and differentiate industrial and agricultural risk mechanisms. Results showed that industrial sources exhibited higher INI values than agricultural sources, indicating stronger pollution accumulation. Industrial risks were predominantly associated with atmospheric deposition and surface runoff pathways. Receptor-based health risk assessments further revealed that children were highly vulnerable to exposure to industrial PTEs, with chromium identified as the dominant contributor to carcinogenic risk. By contrast, agricultural risks were mainly attributed to internal receptors (26.80%) and inputs from irrigation, fertilizers and animal manure (23.20%). Among the agricultural risk zones, dietary exposure through crop consumption represented a crucial pathway, with oilseed rape demonstrating the highest potential health risks. Carcinogenic and non-carcinogenic risks associated with oilseed rape exceed acceptable thresholds. Furthermore, the XGBoost regression model achieved satisfactory predictive performance under an internal 8:2 training-testing validation, with R(2) values of 0.823 and 0.716, respectively. SHAP analysis further revealed different dominant factors governing industrial and agricultural risks. Overall, the proposed framework provides a basis for targeted zoned control and may help avoid excessive remediation in low-risk areas while ensuring sufficient control in high-risk areas. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Su, Chuanghong AU - Su C AD - College of Resources and Environment, Huazhong Agricultural University, Wuhan, 430070, China; Hubei Key Laboratory of Soil Environment and Pollution Remediation, China; Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of Yangtze River), Ministry of Agriculture, China. FAU - Yang, Yong AU - Yang Y AD - College of Resources and Environment, Huazhong Agricultural University, Wuhan, 430070, China; Hubei Key Laboratory of Soil Environment and Pollution Remediation, China; Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of Yangtze River), Ministry of Agriculture, China. Electronic address: yangyong@mail.hzau.edu.cn. FAU - Fu, Peihong AU - Fu P AD - College of Resources and Environment, Huazhong Agricultural University, Wuhan, 430070, China; Hubei Key Laboratory of Soil Environment and Pollution Remediation, China; Key Laboratory of Arable Land Conservation (Middle and Lower Reaches of Yangtze River), Ministry of Agriculture, China. LA - eng PT - Journal Article DEP - 20260827 PL - England TA - Environ Pollut JT - Environmental pollution (Barking, Essex : 1987) JID - 8804476 RN - 0 (Soil Pollutants) RN - 0 (Soil) SB - IM MH - *Machine Learning MH - *Soil Pollutants/analysis MH - Risk Assessment MH - *Environmental Monitoring/methods MH - Agriculture MH - *Soil/chemistry MH - Mining MH - Environmental Pollution/statistics & numerical data MH - Boosting Machine Learning Algorithms OTO - NOTNLM OT - Machine learning OT - Monte Carlo simulation OT - Potentially toxic elements OT - Risk assessment OT - Source-pathway-receptor COIS- Declaration of competing interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/26 23:35 MHDA- 2026/10/15 07:17 CRDT- 2026/08/26 19:13 PHST- 2026/06/24 00:00 [received] PHST- 2026/08/23 00:00 [revised] PHST- 2026/08/26 00:00 [accepted] PHST- 2026/10/15 07:17 [medline] PHST- 2026/08/26 23:35 [pubmed] PHST- 2026/08/26 19:13 [entrez] AID - S0269-7491(26)01422-3 [pii] AID - 10.1016/j.envpol.2026.129052 [doi] PST - ppublish SO - Environ Pollut. 2026 Nov 15;409:129052. doi: 10.1016/j.envpol.2026.129052. Epub 2026 Aug 27. PMID- 42648412 OWN - NLM STAT- Publisher LR - 20260902 IS - 1872-7573 (Electronic) IS - 0378-8741 (Linking) VI - 374 IP - Pt 1 DP - 2026 Aug 26 TI - Pharmacodynamic-oriented serum pharmacochemistry-based discovery of the pharmacodynamic material basis and mechanism of Ohwia caudata leaves against acute ulcerative colitis. PG - 122326 LID - S0378-8741(26)01181-5 [pii] LID - 10.1016/j.jep.2026.122326 [doi] AB - ETHNOPHARMACOLOGICAL RELEVANCE: Ohwia caudata leaves have long been used in traditional Chinese medicine to treat dysentery, gastroenteritis, and infantile malnutrition. However, their effect on ulcerative colitis (UC) remains unclear. AIM OF THE STUDY: This study aimed to investigate the pharmacodynamic material basis and underlying mechanism of O. caudata leaves against acute UC. MATERIALS AND METHODS: An acute UC mouse model was induced by 2.5% dextran sulfate sodium (DSS) to evaluate the pharmacodynamics of the 70% ethanol extract and different extraction/elution fractions of O. caudata leaves. The chemical constituents of the most active fraction were isolated and identified using various chromatographic and spectroscopic techniques. Serum pharmacochemistry coupled with LC-MS was employed to identify prototype components absorbed into the blood. The anti-inflammatory activity of the absorbed components was screened by measuring nitric oxide (NO) production in LPS-stimulated RAW264.7 cells. Network pharmacology was used to predict the potential targets and pathways of the active components, and key signaling pathways were validated by Western blot. RESULTS: The 95% ethanol elution fraction (OCLH) was identified as the main anti-UC active fraction. From this fraction, 81 compounds were isolated and identified, including aliphatic glycosides, ionone glycosides, flavonoid glycosides, etc. 27 prototype components were found to enter the bloodstream, among which 16 exhibited significant inhibitory activity against NO production. Representative flavonoid C-glycosides (compounds 25, 30, 31, 38) significantly suppressed the phosphorylation levels of p38, Erk1/2, and AKT, and down-regulated the protein expression of PI3K, IL-6, and TNF-alpha in LPS-stimulated RAW264.7 cells. CONCLUSION: The 95% ethanol elution fraction of O. caudata leaves is the main pharmacodynamic fraction responsible for ameliorating acute UC. Flavonoid C-glycosides are the key active components, and their mechanism is associated with the intervention of TNF-mediated MAPK and PI3K-AKT signaling pathways. This study provides a scientific basis for the rational clinical application of O. caudata leaves and the discovery of anti-UC lead compounds. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Ruan, Jingya AU - Ruan J AD - Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China. FAU - Zhang, Qianqian AU - Zhang Q AD - School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China. FAU - Geng, Qianqian AU - Geng Q AD - School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China. FAU - Wu, Yijin AU - Wu Y AD - School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China. FAU - Liu, Qian AU - Liu Q AD - School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China. FAU - Zhang, Ping AU - Zhang P AD - School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China. FAU - Zhang, Yi AU - Zhang Y AD - Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China; School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China. Electronic address: zhwwxzh@tjutcm.edu.cn. FAU - Wang, Tao AU - Wang T AD - Tianjin Key Laboratory of TCM Chemistry and Analysis, Tianjin University of Traditional Chinese Medicine, 10 Poyanghu Road, West Area, Tuanbo New Town, Jinghai District, Tianjin, 301617, China. Electronic address: wangtao@tjutcm.edu.cn. LA - eng PT - Journal Article DEP - 20260826 PL - Ireland TA - J Ethnopharmacol JT - Journal of ethnopharmacology JID - 7903310 SB - IM OTO - NOTNLM OT - Mechanism of action OT - Pharmacological substances OT - TNF/MAPK/PI3K-AKT signaling pathway OT - The leaves of O. caudata OT - Ulcerative colitis COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. The authors have used DeepSeek for language polishing of this manuscript. EDAT- 2026/08/26 23:35 MHDA- 2026/08/26 23:35 CRDT- 2026/08/26 19:11 PHST- 2026/06/23 00:00 [received] PHST- 2026/08/19 00:00 [revised] PHST- 2026/08/22 00:00 [accepted] PHST- 2026/08/26 23:35 [pubmed] PHST- 2026/08/26 23:35 [medline] PHST- 2026/08/26 19:11 [entrez] AID - S0378-8741(26)01181-5 [pii] AID - 10.1016/j.jep.2026.122326 [doi] PST - aheadofprint SO - J Ethnopharmacol. 2026 Aug 26;374(Pt 1):122326. doi: 10.1016/j.jep.2026.122326. PMID- 42647367 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260828 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 11 IP - 3 DP - 2026 Aug 22 TI - Comparison of Anthropometric Equations to Estimate Body Composition in Chilean Male Adolescent Soccer Players. LID - 10.3390/jfmk11030326 [doi] LID - 326 AB - Background: Anthropometric body-composition assessment in youth soccer commonly relies on equations developed in different source populations and based on distinct body-composition models, potentially altering nutritional and sport-related interpretation. This study compared body-fat estimates from equations intended to report the same outcome, body fat percentage, but based on different operational models, and quantified muscle-mass outputs from anthropometric approaches targeting total-body skeletal, whole-body, and tissue-level muscle compartments in a cohort of Chilean male U-15 and U-16 players. Methods: This secondary cross-sectional method-comparison study analyzed anonymized anthropometric records collected in 2018 from 50 male players. Slaughter, Faulkner, Carter, Deurenberg, and Sloan-Siri estimates of body fat were compared, together with Poortmans, Lee, Doupe, and Kerr muscle-mass approaches. Absolute agreement among adiposity equations was evaluated using a two-way random-effects, absolute-agreement, single-measure ICC [ICC(A,1)] and Bland-Altman analyses. Muscle-mass approaches were compared with repeated-measures analysis; pairwise difference-versus-mean summaries across different muscle constructs were interpreted descriptively rather than as formal agreement tests. Sensitivity analyses excluded Deurenberg and examined a maturation-related Slaughter scenario. Results: Deurenberg yielded the highest body-fat estimate (18.97 +/- 3.07%), followed by Slaughter (13.32 +/- 3.35%), Faulkner (10.84 +/- 1.40%), Sloan-Siri (8.01 +/- 2.80%), and Carter (7.91 +/- 1.49%). Global differences were large (chi(2)(4) = 182.96; p < 0.001; Kendall's W = 0.915), and individual absolute agreement was low [ICC(A,1) = 0.157; bootstrap 95% CI 0.102-0.212]. Excluding Deurenberg did not remove the between-method differences (chi(2)(3) = 124.44; p < 0.001; W = 0.830). For muscle mass, mean estimates ranged from 25.11 +/- 3.07 kg with Poortmans to 31.26 +/- 4.94 kg with Doupe, with a significant method effect after Greenhouse-Geisser correction (p < 0.001). Conclusions: The adiposity equations yielded substantially different numerical estimates of the same reported outcome, body fat percentage, and showed low individual-level absolute agreement. Muscle-mass approaches also produced large numerical differences, partly expected because they target different compartments. Outputs from different equations or constructs should not be treated as numerically interchangeable. Because no criterion reference method was included, this study quantifies method dependence rather than validity and cannot identify the most accurate equation. FAU - Farfan-Diaz, Alvaro AU - Farfan-Diaz A AUID- ORCID: 0009-0000-2435-0185 AD - Carrera de Nutricion y Dietetica, Facultad de Ciencias de la Salud, Universidad de Tarapaca, Arica 1000000, Chile. FAU - Alarcon-Rivera, Miguel AU - Alarcon-Rivera M AUID- ORCID: 0000-0001-8341-5567 AD - Escuela de Ciencias del Deporte y Actividad Fisica, Facultad de Salud, Universidad Santo Tomas, Talca 3460000, Chile. FAU - Andrade Oyarzun, Marcelo AU - Andrade Oyarzun M AUID- ORCID: 0009-0008-9430-2646 AD - Departamento de Nutricion y Dietetica, Universidad de Magallanes, Punta Arenas 6210427, Chile. AD - Centro Asistencial de Docencia e Investigacion, Universidad de Magallanes (CADI-UMAG), Punta Arenas 6210427, Chile. FAU - Tapia-Villanueva, Daniel AU - Tapia-Villanueva D AUID- ORCID: 0009-0005-8414-7791 AD - Independent Researcher, Santiago 8320000, Chile. FAU - Garcia-Carrillo, Exal AU - Garcia-Carrillo E AUID- ORCID: 0000-0001-6190-938X AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3480112, Chile. AD - Department of Physical Activity Sciences, Universidad de Los Lagos, Osorno 5290000, Chile. FAU - Molina-Marquez, Ivan AU - Molina-Marquez I AUID- ORCID: 0000-0001-6003-5107 AD - Pedagogia en Educacion Fisica, Facultad de Educacion, Universidad Adventista de Chile, Chillan 3780000, Chile. AD - Programa Doctorado en Ciencias de la Actividad Fisica, Universidad Catolica del Maule, Talca 3460000, Chile. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AUID- ORCID: 0000-0002-9311-6576 AD - Escuela de Ciencias del Deporte, Facultad de Educacion y Humanidades, Universidad Andres Bello, Vina del Mar 2200055, Chile. AD - School of Medicine, Universidad Espiritu Santo, Samborondon 092301, Ecuador. FAU - Barrera-Gonzalez, Dario AU - Barrera-Gonzalez D AUID- ORCID: 0000-0003-4799-341X AD - Carrera de Kinesiologia, Facultad de Ciencias de la Salud, Universidad Autonoma de Chile, Talca 3460000, Chile. FAU - Montalva-Valenzuela, Felipe AU - Montalva-Valenzuela F AUID- ORCID: 0000-0003-0004-3089 AD - Escuela de Entrenador en Actividad Fisica y Deporte, Facultad de Ciencias Humanas, Universidad Bernardo O'Higgins, Santiago 8370993, Chile. LA - eng PT - Journal Article DEP - 20260822 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC13511747 OTO - NOTNLM OT - adiposity OT - body composition OT - kinanthropometry OT - method comparison OT - skeletal muscle OT - youth soccer COIS- The authors declare no conflicts of interest. EDAT- 2026/08/26 17:37 MHDA- 2026/08/26 17:38 PMCR- 2026/08/22 CRDT- 2026/08/26 12:54 PHST- 2026/07/17 00:00 [received] PHST- 2026/08/14 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/08/26 17:38 [medline] PHST- 2026/08/26 17:37 [pubmed] PHST- 2026/08/26 12:54 [entrez] PHST- 2026/08/22 00:00 [pmc-release] AID - jfmk11030326 [pii] AID - jfmk-11-00326 [pii] AID - 10.3390/jfmk11030326 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2026 Aug 22;11(3):326. doi: 10.3390/jfmk11030326. PMID- 42647249 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260828 IS - 2409-515X (Electronic) IS - 2409-515X (Linking) VI - 12 IP - 3 DP - 2026 Jul 30 TI - Experience with Implementation of Pulse Oximetry Screening for Critical Congenital Heart Disease in a Low-Middle-Income Country. LID - 10.3390/ijns12030062 [doi] LID - 62 AB - The adoption of pulse oximetry screening (POS) in low- and middle-income countries remains limited. We describe the development, implementation, and evaluation of a POS program at two of the leading tertiary centers in Accra, Ghana, based on a modified American Academy of Pediatrics protocol. Screening was conducted by trained research assistants. Operational experiences of research assistants were evaluated using a mixed-methods approach, including post-implementation surveys (n = 14) and focus group discussions (n = 10). Although participants felt comfortable with the level of instruction, they recommended incorporating simulation exercises to strengthen management of failed screens. Key challenges included difficulty locating newborns due to fragmented wards and paper-based records, equipment durability issues, and complex coordination for echocardiography following failed screens. Early discharge practices and high neonatal intensive care unit admissions reduced screening coverage among high-risk infants. Despite limited referral systems and surgical capacity, the POS pilot increased provider awareness, improved diagnostic clarity and demonstrated feasibility. Sustainable expansion will require more efficient referral networks as well as investment in pediatric cardiology training and cardiac surgical infrastructure. FAU - Adaboh, Abena AU - Adaboh A AD - David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. FAU - Celestin, Daem AU - Celestin D AD - David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. FAU - Agyekum, Alex AU - Agyekum A AD - Korle Bu Teaching Hospital, Accra GA-221-1570, Ghana. FAU - Osei, Nana Serwaa AU - Osei NS AD - Korle Bu Teaching Hospital, Accra GA-221-1570, Ghana. FAU - Mensah, Araba AU - Mensah A AD - Korle Bu Teaching Hospital, Accra GA-221-1570, Ghana. FAU - Sayeed, Sadath AU - Sayeed S AUID- ORCID: 0009-0003-5841-218X AD - David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. FAU - Yao, Nana-Akyaa AU - Yao NA AD - Korle Bu Teaching Hospital, Accra GA-221-1570, Ghana. LA - eng PT - Journal Article DEP - 20260730 PL - Switzerland TA - Int J Neonatal Screen JT - International journal of neonatal screening JID - 101665400 PMC - PMC13511312 OTO - NOTNLM OT - challenges OT - critical congenital heart disease OT - implementation OT - low resource OT - pulse oximetry screening OT - sub-Saharan Africa COIS- The authors declare no conflicts of interest. EDAT- 2026/08/26 17:37 MHDA- 2026/08/26 17:38 PMCR- 2026/07/30 CRDT- 2026/08/26 12:53 PHST- 2026/02/28 00:00 [received] PHST- 2026/07/23 00:00 [revised] PHST- 2026/07/24 00:00 [accepted] PHST- 2026/08/26 17:38 [medline] PHST- 2026/08/26 17:37 [pubmed] PHST- 2026/08/26 12:53 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - ijns12030062 [pii] AID - IJNS-12-00062 [pii] AID - 10.3390/ijns12030062 [doi] PST - epublish SO - Int J Neonatal Screen. 2026 Jul 30;12(3):62. doi: 10.3390/ijns12030062. PMID- 42647245 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260828 IS - 2409-515X (Electronic) IS - 2409-515X (Linking) VI - 12 IP - 3 DP - 2026 Jul 28 TI - Newborn Screening for Neonatal Intrahepatic Cholestasis Caused by Citrin Deficiency and Analysis of SLC25A13 Gene Mutations in Hefei, China. LID - 10.3390/ijns12030058 [doi] LID - 58 AB - Citrin deficiency (CD) is an autosomal recessive disorder and represents one of the urea cycle disorders. This study aims to analyze the detection rate, clinical features, and genetic mutation characteristics of neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) in the Hefei region of China. We conducted NICCD screening using tandem mass spectrometry (MS/MS) for infants born in Hefei City between January 2016 and December 2025. Screen-positive cases were subjected to genetic testing via next-generation sequencing (NGS), with subsequent validation by Sanger sequencing. Clinical manifestations, biochemical parameters, and genetic mutation profiles of confirmed cases were systematically analyzed. A total of 924,676 newborns underwent screening, identifying 17 cases of NICCD, yielding a detection rate of 1/54,393, with two false-negative cases identified. The most prevalent mutation site is c.852_855del (p.M285Pfs*2). Following diagnosis, health education, dietary guidance, and symptomatic treatment were administered, resulting in favorable outcomes in the majority of cases. However, one infant exhibited significant growth retardation despite early therapeutic intervention that normalized biochemical parameters. Furthermore, an infant was found to have gallstones at birth and subsequently diagnosed with a liver hemangioma at one year of age. Some patients may experience missed screenings due to delayed elevations in citrulline levels. Therefore, even for newborns with negative screening results, timely assessments of liver function, MS/MS, and genetic testing are recommended for infants experiencing prolonged jaundice. This approach enables early identification and intervention. The combination of MS/MS with genetic screening may serve as a reliable strategy to reduce false-negative results in NICCD screening. FAU - Ma, Qingqing AU - Ma Q AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230022, China. AD - Anhui Women and Children's Medical Center, Hefei 230001, China. FAU - Chen, Junxing AU - Chen J AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230022, China. FAU - Huang, Yong AU - Huang Y AD - Anhui Women and Children's Medical Center, Hefei 230001, China. FAU - Wang, Yan AU - Wang Y AD - Anhui Women and Children's Medical Center, Hefei 230001, China. FAU - Song, Wangsheng AU - Song W AD - Anhui Women and Children's Medical Center, Hefei 230001, China. FAU - Xu, Hongyu AU - Xu H AD - Anhui Women and Children's Medical Center, Hefei 230001, China. FAU - Wan, Yuhui AU - Wan Y AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230022, China. FAU - Hu, Haili AU - Hu H AUID- ORCID: 0009-0008-8390-406X AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Anhui Medical University, Hefei 230022, China. AD - Anhui Women and Children's Medical Center, Hefei 230001, China. LA - eng GR - hhw-2016yb016/Hefei Municipal Health Commission/ GR - AHWJ2024Aa20311/Health Commission of Anhui Province/ PT - Journal Article DEP - 20260728 PL - Switzerland TA - Int J Neonatal Screen JT - International journal of neonatal screening JID - 101665400 PMC - PMC13510412 OTO - NOTNLM OT - SLC25A13 gene OT - neonatal intrahepatic cholestasis caused by citrin deficiency OT - newborn screening OT - tandem mass spectrometry COIS- The authors declare no conflicts of interest. EDAT- 2026/08/26 17:37 MHDA- 2026/08/26 17:38 PMCR- 2026/07/28 CRDT- 2026/08/26 12:53 PHST- 2026/05/08 00:00 [received] PHST- 2026/07/18 00:00 [revised] PHST- 2026/07/26 00:00 [accepted] PHST- 2026/08/26 17:38 [medline] PHST- 2026/08/26 17:37 [pubmed] PHST- 2026/08/26 12:53 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - ijns12030058 [pii] AID - IJNS-12-00058 [pii] AID - 10.3390/ijns12030058 [doi] PST - epublish SO - Int J Neonatal Screen. 2026 Jul 28;12(3):58. doi: 10.3390/ijns12030058. PMID- 42646607 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260918 IS - 2076-3271 (Electronic) IS - 2076-3271 (Linking) VI - 14 IP - 4 DP - 2026 Aug 12 TI - Exercise-Based Interventions for the Management of Low Back Pain in Adolescents in School Settings: A Systematic Review. LID - 10.3390/medsci14040473 [doi] LID - 473 AB - BACKGROUND/OBJECTIVES: To synthesize the effects of school-based exercise interventions in adolescents with nonspecific low back pain. METHODS: PubMed/MEDLINE, Scopus, Web of Science, CENTRAL, PEDro, ScienceDirect, and supplementary sources were searched through 21 May 2026. Randomized and quasi-randomized controlled trials involving adolescents aged 10-19 years and delivering exercise wholly or substantially within schools were eligible. Risk of bias was assessed using Cochrane RoB 1, and findings were synthesized narratively. RESULTS: Of 1935 records, two randomized trials and one quasi-experimental controlled trial (194 allocated participants) were included. Fanucchi et al. reported between-group reductions in past-month pain of 2.2 cm on a 10-cm visual analogue scale (95% CI 1.0-3.5) at 3 months and 2.0 cm (95% CI 0.5-3.5) at 6 months; absolute reductions in 3-month low back pain prevalence were 24% (95% CI 4-41) and 40% (95% CI 18-57), respectively. Jones et al. reported a large effect size for pain severity after 8 weeks (ES = 1.47). Javadipour et al. reported favorable pain and motor-function outcomes, but incomplete and internally inconsistent reporting limited interpretation. No study assessed low-back-pain-related disability using a validated instrument. All studies had high risk of bias in at least one domain, most commonly blinding. Heterogeneity precluded meta-analysis. CONCLUSIONS: Limited evidence suggests that school-based exercise may reduce pain intensity and pain prevalence over six months and improve selected physical outcomes in adolescents aged 12-15 years. The small, heterogeneous evidence base and risk of bias preclude conclusions or recommendations regarding modality or dosage. FAU - Tarao, Gismael M AU - Tarao GM AUID- ORCID: 0009-0002-8648-0887 AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Afonso, Joao Pedro R AU - Afonso JPR AUID- ORCID: 0000-0002-1392-4910 AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Ribeiro, Alex S AU - Ribeiro AS AUID- ORCID: 0000-0002-0312-8857 AD - Faculty of Sports Sciences and Physical Education (FCDEF), University of Coimbra, CIPER, 3004-531 Coimbra, Portugal. FAU - Stocco, Marieli R AU - Stocco MR AD - Physhiotherapy Department, The State University of Northern Parana (UENP), Jacarezinho 86400-000, Brazil. FAU - Bovi, Adriana AU - Bovi A AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Barbosa, Ludymilla V AU - Barbosa LV AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Pinto, Andre L AU - Pinto AL AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Oliveira, Claudia S AU - Oliveira CS AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Carvalho, Karla C N de AU - Carvalho KCN AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Oliveira, Miria C AU - Oliveira MC AUID- ORCID: 0000-0002-5302-1388 AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Quirino, Fernanda S P AU - Quirino FSP AUID- ORCID: 0009-0008-9420-6371 AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Oliveira, Glauber A AU - Oliveira GA AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Sampaio, Andreia C R I AU - Sampaio ACRI AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Masri, Dunya O AU - Masri DO AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Oliveira, Luis V F AU - Oliveira LVF AUID- ORCID: 0000-0002-3852-9415 AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Fernandes, Tiago V AU - Fernandes TV AD - Department Rehabilitation, Barretos Cancer Hospital, Barretos 14784-400, Brazil. AD - Health Sciences Graduate Program (PPGCS), Faculty of Medical Sciences (FCMSCSP), Irmandade da Santa Casa de Misericordia de Sao Paulo, Sao Paulo 01221-010, Brazil. FAU - Filho, Hustenio A A AU - Filho HAA AD - Health Sciences Graduate Program (PPGCS), Faculty of Medical Sciences (FCMSCSP), Irmandade da Santa Casa de Misericordia de Sao Paulo, Sao Paulo 01221-010, Brazil. FAU - Capodaglio, Paolo AU - Capodaglio P AUID- ORCID: 0000-0003-3719-8789 AD - Orthopaedic Rehabilitation Unit, Research Laboratory for Biomechanics, Rehabilitation and Ergonomics, Ospedale San Giuseppe, 20123 Milan, Italy. AD - Physical and Rehabilitation Medicine Sector, Department of Biomedical, Surgical and Dental Sciences, University of Milan, 20122 Milan, Italy. FAU - Maia, Luciana P AU - Maia LP AUID- ORCID: 0000-0001-5697-2587 AD - Dentistry Graduate Program, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. FAU - Andraus, Rodrigo A C AU - Andraus RAC AUID- ORCID: 0000-0002-3849-0872 AD - Graduate Program in Human Movement and Rehabilitation, Evangelical University of Goias (UniEVANGELICA), Anapolis 75083-515, Brazil. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260812 PL - Switzerland TA - Med Sci (Basel) JT - Medical sciences (Basel, Switzerland) JID - 101629322 SB - IM MH - Humans MH - *Low Back Pain/therapy MH - Adolescent MH - *Exercise Therapy/methods MH - Schools MH - Child PMC - PMC13515185 OTO - NOTNLM OT - adolescents OT - exercise therapy OT - low back pain OT - rehabilitation OT - school-based intervention COIS- The authors declare no conflicts of interest. EDAT- 2026/08/26 17:37 MHDA- 2026/08/26 17:38 PMCR- 2026/08/12 CRDT- 2026/08/26 11:31 PHST- 2026/07/03 00:00 [received] PHST- 2026/08/03 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/26 17:38 [medline] PHST- 2026/08/26 17:37 [pubmed] PHST- 2026/08/26 11:31 [entrez] PHST- 2026/08/12 00:00 [pmc-release] AID - medsci14040473 [pii] AID - medsci-14-00473 [pii] AID - 10.3390/medsci14040473 [doi] PST - epublish SO - Med Sci (Basel). 2026 Aug 12;14(4):473. doi: 10.3390/medsci14040473. PMID- 42646535 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260828 IS - 2039-4403 (Electronic) IS - 2039-439X (Print) IS - 2039-439X (Linking) VI - 16 IP - 8 DP - 2026 Aug 4 TI - Development of Thai-Specific Gestational Weight Gain Targets Using Asian BMI Cut-Points: Implications for Nursing and Midwifery Practice in Preventing Gestational Diabetes Mellitus. LID - 10.3390/nursrep16080274 [doi] LID - 274 AB - Background: Thai obstetric nurses follow WHO gestational weight gain (GWG) guidelines to prevent gestational diabetes mellitus (GDM). However, these Western-derived guidelines misclassify approximately 16% of Thai pregnant women, who carry excess metabolic risk at lower BMI values than Western populations. Objectives: To derive and validate Thai-specific GWG targets using Thai BMI cut-points across five BMI subgroups and assess implications for nursing practice in GDM prevention. Methods: Retrospective cohort study of 1396 Thai singleton pregnancies at a maternal and child hospital (2023-2025). GWG targets were derived as interquartile ranges (P25-P75) from a healthy-outcomes subgroup (n = 706), with validity confirmed by multivariable logistic regression and a 70:30 derivation/validation split. Results: GDM prevalence was 15.8%, with a rising crude trend that was attenuated after accounting for a mid-study change in screening protocol. Provisional Thai-specific GWG targets were underweight/normal weight 11.5-18.0 kg, overweight 9.7-18.0 kg, obesity class I 9.1-16.0 kg, and obesity class II+ 5.8-12.1 kg. Inadequate GWG in obesity class I was associated with a 3.92-fold GDM risk increase (aOR 3.92, 95% CI 2.12-7.24, p < 0.001). Adherence improved from 34.7% (IOM 2009) to 50.2% with Thai-specific targets. Conclusions: These Thai-specific GWG targets are provisional, single-centre pilot estimates. They appear clinically safe and are substantially more achievable than IOM 2009 criteria and are offered to inform BMI-appropriate antenatal counselling and to justify a multi-centre validation study, rather than as ranges that are ready for immediate national adoption. FAU - Xuto, Piyanut AU - Xuto P AUID- ORCID: 0000-0003-1338-0789 AD - Faculty of Nursing, Chiang Mai University, 110/406 Intawaroros rd., Suthep, Muang, Chiang Mai 50200, Thailand. FAU - Bressington, Daniel AU - Bressington D AUID- ORCID: 0000-0003-0951-2208 AD - Faculty of Nursing, Chiang Mai University, 110/406 Intawaroros rd., Suthep, Muang, Chiang Mai 50200, Thailand. FAU - Khiaokham, Lawitra AU - Khiaokham L AUID- ORCID: 0000-0002-4008-5446 AD - Faculty of Nursing, Chiang Mai University, 110/406 Intawaroros rd., Suthep, Muang, Chiang Mai 50200, Thailand. FAU - Khaw-On, Patompong AU - Khaw-On P AUID- ORCID: 0000-0002-9965-5319 AD - Faculty of Nursing, Chiang Mai University, 110/406 Intawaroros rd., Suthep, Muang, Chiang Mai 50200, Thailand. FAU - Matayaboon, Nantarat AU - Matayaboon N AUID- ORCID: 0009-0002-9365-0733 AD - Faculty of Nursing, Chiang Mai University, 110/406 Intawaroros rd., Suthep, Muang, Chiang Mai 50200, Thailand. FAU - Sangsawang, Suraphan AU - Sangsawang S AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Janta, Nantawan AU - Janta N AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Sungplipan, Pradab AU - Sungplipan P AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Wiangsuwan, Suratsawadee AU - Wiangsuwan S AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Chaiwatthanakorn, Sujitra AU - Chaiwatthanakorn S AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Phiwon, Ampaporn AU - Phiwon A AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Khetwang, Kamonchanok AU - Khetwang K AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. FAU - Charuloedphong, Ratchaneewan AU - Charuloedphong R AD - Regional Health Promotion Center 1, Department of Health, Ministry of Public Health, Chiang Mai 50100, Thailand. LA - eng GR - The Chiang Mai University International Visiting Professor Fellowship scheme./Chiang Mai University/ PT - Journal Article DEP - 20260804 PL - Switzerland TA - Nurs Rep JT - Nursing reports (Pavia, Italy) JID - 101592662 PMC - PMC13516527 OTO - NOTNLM OT - Asian populations OT - antenatal care OT - body mass index OT - gestational diabetes mellitus OT - gestational weight gain OT - midwifery OT - nursing COIS- The authors declare no conflicts of interest. EDAT- 2026/08/26 17:37 MHDA- 2026/08/26 17:38 PMCR- 2026/08/04 CRDT- 2026/08/26 11:31 PHST- 2026/06/22 00:00 [received] PHST- 2026/07/26 00:00 [revised] PHST- 2026/07/31 00:00 [accepted] PHST- 2026/08/26 17:38 [medline] PHST- 2026/08/26 17:37 [pubmed] PHST- 2026/08/26 11:31 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - nursrep16080274 [pii] AID - nursrep-16-00274 [pii] AID - 10.3390/nursrep16080274 [doi] PST - epublish SO - Nurs Rep. 2026 Aug 4;16(8):274. doi: 10.3390/nursrep16080274. PMID- 42644700 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260826 IS - 1938-2359 (Electronic) IS - 0090-4481 (Linking) VI - 55 IP - 8 DP - 2026 Aug TI - Structured Approach to Pediatric Acute Gastroenteritis: Discussion of Diagnostics and Treatment of Acute Gastroenteritis in Children. PG - e323-e327 LID - 10.3928/19382359-20260609-05 [doi] AB - Pediatric acute gastroenteritis remains a leading global cause of mortality and malnutrition, accounting for 1.7 billion annual cases. Despite its prevalence, management remains variable. This article advocates for a transition from unstructured clinical "gestalt" to evidence-based frameworks in order to improve outcomes. Diagnostic evaluation should prioritize validated tools, like the Clinical Dehydration Scale and the Gorelick Scale, as physician intuition often lacks precision. Laboratory diagnostics and polymerase chain reaction testing should be reserved for severe cases or patients with high risk to avoid over testing. Management emphasizes oral rehydration therapy as the gold standard for mild-to-moderate dehydration, supported by single-dose ondansetron to reduce intravenous (IV) fluid reliance and hospitalization. Antimicrobials are indicated only for specific pathogens (eg, Shigella, Vibrio cholerae) or immunocompromised hosts. Finally, there is discussion on systemic health disparities-noting that children who are Black and not Hispanic and children who are Hispanic are statistically less likely to receive IV fluids or admission-underscoring the role of standardized guidelines in ensuring equitable, high-value care. FAU - Traisman, Benjamin AU - Traisman B AD - Department of Pediatric Hospital Medicine, Ann and Robert H. Lurie Children's Hospital. FAU - Kilaru, Raga AU - Kilaru R AD - Department of Pediatric Hospital Medicine, Ann and Robert H. Lurie Children's Hospital. FAU - Parikh, Sonia AU - Parikh S AD - Department of Pediatric Hospital Medicine, Ann and Robert H. Lurie Children's Hospital. FAU - Listernick, Zoe AU - Listernick Z AD - Department of Pediatric Hospital Medicine, Ann and Robert H. Lurie Children's Hospital. AD - Northwestern University Feinberg School of Medicine, Chicago, Illinois. LA - eng PT - Journal Article PT - Review DEP - 20260801 PL - United States TA - Pediatr Ann JT - Pediatric annals JID - 0356657 SB - IM MH - Humans MH - *Gastroenteritis/diagnosis/therapy/complications MH - Acute Disease MH - Fluid Therapy/methods MH - Dehydration/therapy/etiology/diagnosis MH - Child COIS- Disclosure: The authors have disclosed no potential conflicts of interest, financial or otherwise. EDAT- 2026/08/26 11:50 MHDA- 2026/08/26 11:51 CRDT- 2026/08/26 09:46 PHST- 2026/08/26 11:51 [medline] PHST- 2026/08/26 11:50 [pubmed] PHST- 2026/08/26 09:46 [entrez] AID - 10.3928/19382359-20260609-05 [doi] PST - ppublish SO - Pediatr Ann. 2026 Aug;55(8):e323-e327. doi: 10.3928/19382359-20260609-05. Epub 2026 Aug 1. PMID- 42644658 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260828 IS - 1746-1561 (Electronic) IS - 0022-4391 (Print) IS - 0022-4391 (Linking) VI - 96 IP - 9 DP - 2026 Sep TI - Wearable-Supported Physical Education for Physical Activity and Psychosocial Beliefs in Underserved Adolescents. PG - e70219 LID - 10.1111/josh.70219 [doi] LID - e70219 AB - BACKGROUND: Despite well-established health benefits of moderate-to-vigorous physical activity (MVPA), many youth, especially from low-income households, remain insufficiently active. This study examined the feasibility and preliminary efficacy of a fitness wearable-supported intervention to increase MVPA in physical education (PE) classes among underserved adolescents. METHODS: Four PE classes (N = 55 enrolled; ages 11-14) at a low-income public school were assigned to either a two-week wearable-supported PE or usual PE, and analyses included the 52 students with pre- and post-assessment data. Feasibility benchmarks (recruitment, retention, data completeness, adherence, dose, technology) were compared against benchmarks set a priori. Between-group differences in change in MVPA (actigraphy) and psychosocial beliefs (questionnaires) were analyzed using ANCOVA or non-parametric equivalent tests. RESULTS: Recruitment, retention, data collection, and technology adherence benchmarks were met. A significant interaction for MVPA of in-class PE was observed (F(1, 47) = 14.60, p < 0.01, etap2 = 0.24), favoring the intervention group. No significant improvements in psychosocial beliefs were observed in either group. IMPLICATIONS FOR SCHOOL HEALTH POLICY, PRACTICE, AND EQUITY: Schools and health professionals may consider integrating digital health tools, aligned with evidence-based pedagogical strategies and behavior change techniques to facilitate health-enhancing physical activity. CONCLUSIONS: Self-monitoring and real-time feedback via fitness wearables may increase in-class engagement in MVPA among underserved adolescents, however, further studies are warranted to strengthen the evidence in this population. CI - (c) 2026 American School Health Association. FAU - Ryu, Suryeon AU - Ryu S AUID- ORCID: 0000-0002-8080-8821 AD - School of Kinesiology, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA. AD - Center for Children's Healthy Lifestyles and Nutrition, Children's Mercy, Kansas City, Missouri, USA. FAU - Kringle, Emily AU - Kringle E AD - School of Kinesiology, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA. FAU - Gao, Zan AU - Gao Z AD - Department of Kinesiology, Recreation, and Sport Studies, University of Tennessee, Knoxville, Tennessee, USA. LA - eng PT - Journal Article PL - United States TA - J Sch Health JT - The Journal of school health JID - 0376370 SB - IM MH - Humans MH - Female MH - Child MH - *Physical Education and Training/methods MH - Male MH - Adolescent MH - *Exercise/psychology MH - *Wearable Electronic Devices MH - *Vulnerable Populations/psychology MH - Feasibility Studies MH - Digital Health MH - Poverty MH - School Health Services PMC - PMC13509092 OTO - NOTNLM OT - digital health literacy OT - health equity OT - health technology OT - physical activity disparities OT - self-regulation COIS- The authors declare no conflicts of interest. EDAT- 2026/08/26 11:50 MHDA- 2026/08/26 11:51 PMCR- 2026/08/26 CRDT- 2026/08/26 09:22 PHST- 2026/07/08 00:00 [revised] PHST- 2025/12/02 00:00 [received] PHST- 2026/08/08 00:00 [accepted] PHST- 2026/08/26 11:51 [medline] PHST- 2026/08/26 11:50 [pubmed] PHST- 2026/08/26 09:22 [entrez] PHST- 2026/08/26 00:00 [pmc-release] AID - JOSH70219 [pii] AID - 10.1111/josh.70219 [doi] PST - ppublish SO - J Sch Health. 2026 Sep;96(9):e70219. doi: 10.1111/josh.70219. PMID- 42644423 OWN - NLM STAT- Publisher LR - 20260826 IS - 1464-5165 (Electronic) IS - 0963-8288 (Linking) DP - 2026 Aug 26 TI - Optimizing upper extremity rehabilitation in children with unilateral spastic cerebral palsy: adjunctive strategies and an integrative framework. PG - 1-16 LID - 10.1080/09638288.2026.2719950 [doi] AB - PURPOSE: Intensive, motor learning-based interventions such as constraint-induced movement therapy and bimanual training improve upper extremity outcomes in children with unilateral spastic cerebral palsy, yet required effective dosages are difficult to deliver in clinical settings. This paper conceptualizes how adjunctive strategies may optimize upper extremity rehabilitation by addressing translational constraints. MATERIALS AND METHODS: This perspective integrates selected empirical findings and theory-driven interpretation informed by our experience in pediatric neurorehabilitation and motor learning. Rather than offering a comprehensive review, we use representative evidence to motivate a novel framework and provide pragmatic judgements for clinicians and researchers. RESULTS: Although high-dose, motor learning-based therapies remain the gold standard to improve upper extremity function, implementation is limited by time, cost, and service-delivery constraints. Adjunctive strategies may enhance feasibility through complementary mechanisms: dose modification (e.g., neuromodulation paired with training to enhance responsiveness to practice); and dose distribution (e.g., home-based training, telerehabilitation, and recreational physical activity, which redistribute structured motor practice across varied contexts). Together, these approaches may support sustained practice, motivation, and participation beyond the clinic. CONCLUSION: We propose an integrative framework that positions adjunctive strategies as complements to, rather than replacements for, intensive motor learning-based interventions, supporting upper extremity improvements with fewer clinical hours. FAU - Metelski, Nicole AU - Metelski N AD - Department of Biobehavioral Sciences, Teachers College, Columbia University, New York, NY, USA. FAU - Gordon, Andrew M AU - Gordon AM AD - Department of Biobehavioral Sciences, Teachers College, Columbia University, New York, NY, USA. LA - eng PT - Journal Article DEP - 20260826 PL - England TA - Disabil Rehabil JT - Disability and rehabilitation JID - 9207179 SB - IM OAB - High-dose, motor learning-based upper extremity therapies remain the gold standard for children with unilateral spastic cerebral palsy, but feasibility is limited by time, cost, and service-delivery constraints.Adjunctive strategies can support upper extremity improvements by enhancing responsiveness to practice or by redistributing practice across settings and schedules.Individual factors, including neurophysiology, age, family capacity, and practice context, should inform selection and integration of adjunctive strategies alongside clinic-based therapy.Distributing motor practice across clinical, home, school, and community contexts may help preserve task-specific, goal-directed practice while reducing reliance on high-dose clinic-based therapy. OABL- eng OTO - NOTNLM OT - Unilateral spastic cerebral palsy OT - home-based training OT - intensive training OT - noninvasive brain stimulation OT - recreational physical activity OT - telerehabilitation OT - therapy dosage OT - upper extremity rehabilitation EDAT- 2026/08/26 11:50 MHDA- 2026/08/26 11:50 CRDT- 2026/08/26 07:33 PHST- 2026/08/26 11:50 [medline] PHST- 2026/08/26 11:50 [pubmed] PHST- 2026/08/26 07:33 [entrez] AID - 10.1080/09638288.2026.2719950 [doi] PST - aheadofprint SO - Disabil Rehabil. 2026 Aug 26:1-16. doi: 10.1080/09638288.2026.2719950. PMID- 42643926 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260827 IS - 1831-4732 (Electronic) IS - 1831-4732 (Linking) VI - 24 IP - 8 DP - 2026 Aug TI - Modification of the existing maximum residue levels for potassium phosphonates in various crops. PG - e10290 LID - 10.2903/j.efsa.2026.10290 [doi] LID - e10290 AB - In accordance with Article 6 of Regulation (EC) No 396/2005, the applicants DE SANGOSSE S.A.S and Tilco-Alginure submitted a request to the competent national authorities in France and Germany to modify the existing maximum residue levels (MRL) for the active substance potassium phosphonates in banana, pineapples, radish roots and leaves (classified under the subgroup of kales at the time of the MRL application), beans without pods, peas with and without pods and sugar beets. The data submitted in support of the requested uses were found to be sufficient to derive MRL proposals for all crops under assessment except peas with pods. Adequate analytical methods for enforcement are available to control the residues of phosphonic acid in plant matrices, the commodities under consideration at the validated LOQ of 0.1 mg/kg. Based on the risk assessment results, EFSA concluded that the long-term intake of residues resulting from the use of potassium phosphonate according to the reported agricultural practices according to the current ADI of 1 mg/kg bw day is unlikely to present a risk to consumer health. A second assessment using the lower ADI of 0.69 mg/kg bw per day proposed in the peer review of choline hydrogen phosphonate confirmed the exceedances previously identified during the peer review for the Dutch toddler and German children diets. Should the proposed lower ADI be endorsed by risk managers, EFSA recommends a revision of the assessment of the existing MRLs for phosphonic acid and its salts, expressed as phosphonic acid. CI - (c) 2026 European Food Safety Authority. EFSA Journal published by Wiley-VCH GmbH on behalf of European Food Safety Authority. CN - European Food Safety Authority (EFSA) FAU - Bellisai, Giulia AU - Bellisai G FAU - Bernasconi, Giovanni AU - Bernasconi G FAU - Castellan, Irene AU - Castellan I FAU - Del Aguila, Monica AU - Del Aguila M FAU - Ferreira, Lucien AU - Ferreira L FAU - Leuschner, Renata AU - Leuschner R FAU - Mioc, Andrea AU - Mioc A FAU - Szot, Marta AU - Szot M FAU - Tiramani, Manuela AU - Tiramani M FAU - Verani, Alessia AU - Verani A LA - eng PT - Journal Article DEP - 20260825 PL - United States TA - EFSA J JT - EFSA journal. European Food Safety Authority JID - 101642076 PMC - PMC13504444 OTO - NOTNLM OT - MRL OT - consumer risk assessment OT - pesticide OT - phosphonic acid OT - potassium phosphonates OT - various crops EDAT- 2026/08/26 11:50 MHDA- 2026/08/26 11:51 PMCR- 2026/08/25 CRDT- 2026/08/26 06:29 PHST- 2026/08/26 11:51 [medline] PHST- 2026/08/26 11:50 [pubmed] PHST- 2026/08/26 06:29 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - EFS210290 [pii] AID - 10.2903/j.efsa.2026.10290 [doi] PST - epublish SO - EFSA J. 2026 Aug 25;24(8):e10290. doi: 10.2903/j.efsa.2026.10290. eCollection 2026 Aug. PMID- 42643824 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260827 IS - 2383-1219 (Electronic) IS - 2345-5152 (Print) IS - 2345-5152 (Linking) VI - 13 IP - 3 DP - 2026 Jul TI - The Correlations between Spatial Equality and School Environment with Children's Physical Activity Levels: The Mediating Role of Motivation toward Physical Education. PG - 196-204 LID - 10.30476/intjsh.2026.109473.1592 [doi] AB - BACKGROUND: Children's engagement in physical activity (PA) is influenced by a combination of environmental and psychological factors. The present study aimed to investigate the correlation of spatial equality and the school environment with children's PA levels, given the mediating role of motivation toward physical education (PE). METHODS: A cross-sectional survey was conducted in 2024 in Gorgan, Iran, involving 384 middle-school students (mean age=13.1+/-0.9 years; 194 (50.5%) female and 190 (49.5%) male students). The study participants completed validated questionnaires assessing spatial equality (NEWS-Y), the school environment (SPAEQ), motivation for PE (PEMS), and PA levels (PAQ-C). Structural equation modeling (SEM) was used to investigate both direct and indirect correlations between the variables of the study. RESULTS: Boys exhibited significantly higher levels of PA (M=3.38+/-0.70) compared with girls (M=3.18+/-0.73; P=0.012). Both spatial equality and the school environment were positively correlated with motivation for PE (r=0.62, P<0.001; r=0.59, P<0.001, respectively) and with PA (r=0.48, P<0.001; r=0.51, P<0.001, respectively). SEM results revealed significant correlations of spatial equality (beta=0.14, P=0.005) and the school environment (beta=0.18, P<0.001) with PA, with motivation toward PE acting as a partial mediator (indirect beta=0.15-0.22, P<0.001). CONCLUSIONS: The study results underscored the importance of comprehensive school interventions that integrate equitable infrastructure aimed at enhancing student motivation, thereby encouraging the development of lifelong habits of PA. CI - Copyright: (c) International Journal of School Health. FAU - Monadi, Aref AU - Monadi A AD - Department of Urban Engineering, Faculty of Architecture and Urban Design, Sooreh International University, Tehran, Iran. FAU - Dana, Amir AU - Dana A AD - Department of Physical Education, Ta.C, Islamic Azad University, Tabriz, Iran. FAU - Ghorbani, Saeed AU - Ghorbani S AD - Department of Physical Education, Isl.C., Islamic Azad University, Islamshahr, Iran. LA - eng PT - Journal Article DEP - 20260701 PL - Iran TA - Int J Sch Health JT - International journal of school health JID - 101702483 PMC - PMC13504179 OTO - NOTNLM OT - Environment OT - Exercise OT - Motivation OT - Schools OT - Spatial Equality COIS- None declared. EDAT- 2026/08/26 11:50 MHDA- 2026/08/26 11:51 PMCR- 2026/07/01 CRDT- 2026/08/26 06:18 PHST- 2025/11/02 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2026/01/04 00:00 [accepted] PHST- 2026/08/26 11:51 [medline] PHST- 2026/08/26 11:50 [pubmed] PHST- 2026/08/26 06:18 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - intjsh-13-3 [pii] AID - 10.30476/intjsh.2026.109473.1592 [doi] PST - epublish SO - Int J Sch Health. 2026 Jul 1;13(3):196-204. doi: 10.30476/intjsh.2026.109473.1592. eCollection 2026 Jul. PMID- 42643582 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260827 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Pulmonary function and risk factors in pediatric chest tightness variant asthma: a case-control study. PG - 1842381 LID - 10.3389/fped.2026.1842381 [doi] LID - 1842381 AB - OBJECTIVE: To investigate the pulmonary function characteristics and risk factors for pediatric chest tightness variant asthma (CTVA). METHODS: A retrospective case-control study was conducted. Clinical data of 39 children diagnosed with CTVA in our outpatient department from February 2022 to February 2024 were analyzed. Fifty healthy children undergoing physical examinations during the same period were enrolled as controls. All participants underwent fractional exhaled nitric oxide (FeNO) measurement and pulmonary ventilation function tests at initial diagnosis or physical examination. FeNO levels and pulmonary function parameters were compared between groups. Baseline demographic and clinical data were recorded. Univariate logistic regression analyses were performed to explore factors associated with pediatric CTVA. Due to the limited sample size (39 cases) and an event-per-variable ratio below the recommended minimum of 10:1 for reliable multivariable modeling, multivariate analysis was not performed. RESULTS: FeNO levels were significantly higher in the CTVA group than in the healthy control group (p = 0.016). FEV1/FVC, PEF, FEF25, FEF50, and FEF75 were significantly lower in the CTVA group (all p < 0.05), whereas FEV1, FVC, and MMEF showed no significant differences (p > 0.05). Significant intergroup differences were observed for obesity, inhalant allergen sensitization, allergic rhinitis, atopic dermatitis, history of recurrent respiratory infections, and family history of allergic diseases (all p < 0.05). Univariate logistic regression analysis confirmed these six factors as significantly associated with pediatric CTVA (all p < 0.05).ntified these six factors as potential independent risk factors for pediatric CTVA (all p < 0.05). CONCLUSION: Children with CTVA have higher FeNO levels and lower FEV1/FVC, PEF, FEF25, FEF50, and FEF75 compared to healthy peers. Obesity, inhalant allergens, allergic rhinitis, atopic dermatitis, recurrent respiratory infections, and family history of allergic diseases showed significant univariate associations with pediatric CTVA in this exploratory cohort. Combined assessment of FeNO and small airway parameters may aid in the diagnostic evaluation of CTVA, although further diagnostic accuracy studies are needed. CI - (c) 2026 Cao, He, Yu and Tong. FAU - Cao, Ruo-Yu AU - Cao RY AD - Department of Pediatrics, Cangzhou Central Hospital, Cangzhou, Hebei, China. FAU - He, Wei-Chao AU - He WC AD - Department of Pediatrics, Cangzhou Central Hospital, Cangzhou, Hebei, China. FAU - Yu, Ya-Bin AU - Yu YB AD - Department of Pediatrics, Hejian City Hospital of TCM, Cangzhou Central Hospital Medical Group, Hejian City, Hebei, China. FAU - Tong, Shan-Shan AU - Tong SS AD - Department of Pediatrics, Cangzhou Central Hospital, Cangzhou, Hebei, China. LA - eng PT - Journal Article DEP - 20260811 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13503571 OTO - NOTNLM OT - chest tightness variant asthma OT - children OT - fractional exhaled nitric oxide (FENO) OT - pulmonary function OT - risk factors COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/26 11:50 MHDA- 2026/08/26 11:51 PMCR- 2026/08/11 CRDT- 2026/08/26 05:49 PHST- 2026/03/30 00:00 [received] PHST- 2026/07/24 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/08/26 11:51 [medline] PHST- 2026/08/26 11:50 [pubmed] PHST- 2026/08/26 05:49 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - 10.3389/fped.2026.1842381 [doi] PST - epublish SO - Front Pediatr. 2026 Aug 11;14:1842381. doi: 10.3389/fped.2026.1842381. eCollection 2026. PMID- 42643513 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260826 LR - 20260827 IS - 2755-0834 (Electronic) IS - 2755-0834 (Linking) VI - 10 DP - 2026 Jan-Dec TI - Prevalence of anemia and years lived with disability in eastern Sub-Saharan Africa, 1990 to 2023. PG - 27550834261483633 LID - 10.1177/27550834261483633 [doi] LID - 27550834261483633 AB - BACKGROUND: Anemia remains a significant public health challenge in the Eastern Sub-Saharan Africa region, contributing to substantial morbidity and adverse outcomes across the lifespan. Understanding trends in the prevalence anemia due to all causes and the years lived with disability is critical for informing targeted interventions and strengthening health systems in the region. METHODS: This study followed the methodological framework of the Global Burden of Disease 2023 study to estimate the prevalence of anemia and the years lived with disability in the Eastern Sub-Saharan African region from 1990 to 2023. Data were synthesized from a broad range of sources, including population-based surveys, antenatal clinic records, hospital registries, and demographic surveillance systems. Bayesian meta-regression tool for disease modeling (DisMod-MR 2.1) was used to estimate prevalence and years lived with disability. Estimates were stratified by age, sex, and locations, ensuring internal consistency over time and across subpopulations. All estimates were reported with 95% uncertainty intervals. RESULTS: The age-standardized prevalence of anemia due to all causes was estimated to be 38,264 cases per 100,000 population (95% UI: 32,886-46,273), and the age-standardized years lived with disability was 1,247 years lived with disability per 100,000 population (95% UI: 787-2,015). Mild anemia (19.9% (95% UI: 15.6-27.3)) and moderate anemia (16.7% (95% UI: 13.5-20.2)) contributed higher share of the prevalence, whereas moderate anemia contributed the most for the years lived with disability (7% (95% UI: 5.4-9.3)). CONCLUSION: This study has underscores that the prevalence of anemia due to all causes and the years lived with disability were high in the Eastern Sub-Saharan African region, with under-five children disproportionately affected and stagnant trend over the past three decades. Strengthening nutrition programs, improving access to healthcare services, and implementing context-specific strategies are critical to accelerating progress toward anemia reduction in the region. CI - (c) The Author(s) 2026. FAU - Tadesse, Sebsibe AU - Tadesse S AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 AD - National Data Management and Analytics Center for Health, Ethiopian Public Health Institute, Addis Ababa, Ethiopia. FAU - Aliyo, Alqeer AU - Aliyo A AUID- ORCID: 0000-0001-7301-5332 AD - Department of Medical Laboratory Science, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 FAU - Gebremeskel Ftwi, Fre AU - Gebremeskel Ftwi F AD - Department of Nutrition and Health System, School of Public Health, College of Medicine and Health Sciences, Adgirat University, Adigrat, Ethiopia. FAU - Gezae, Kebede Embaye AU - Gezae KE AD - Faculty of Public Health, College of Health Sciences, Mekelle University, Mekelle, Ethiopia. RINGGOLD: 128165 FAU - Ashenafi, Girma AU - Ashenafi G AD - Department of Medical Laboratory Science, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 FAU - Beyene, Belda Negesa AU - Beyene BN AUID- ORCID: 0000-0002-0586-0080 AD - Department of Midwifery, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 FAU - Fikrie, Anteneh AU - Fikrie A AUID- ORCID: 0000-0002-9809-3326 AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. RINGGOLD: 435723 LA - eng PT - Journal Article DEP - 20260824 PL - United States TA - J Med Access JT - The journal of medicine access JID - 9918367185906676 PMC - PMC13504108 OAB - Anemia, characterized by severe fatigue and weakness resulting from a deficiency of healthy red blood cells, remains a critical public health crisis in East Africa, disproportionately affecting young children. We evaluated regional health data spanning 1990 to 2023 to assess anemia prevalence, its functional impact on daily life, and the demographic groups most severely affected. Regional progress has entirely stagnated. Anemia prevalence in 2023 mirrored 1990 levels, impacting approximately 38% of the population. Although mild cases predominate, moderate anemia accounts for the greatest burden of physical exhaustion, with children under five remaining the most vulnerable demographic. Three decades of public health interventions have failed to reduce anemia in the region. Breaking this persistent cycle requires governments to urgently scale up targeted nutritional programs and strengthen basic healthcare access for vulnerable households. OABL- eng OTO - NOTNLM OT - anemia OT - burden OT - global burden of diseases OT - prevalence OT - types of anemia OT - under-five children OT - years lived with disability COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/08/26 11:50 MHDA- 2026/08/26 11:51 PMCR- 2026/08/24 CRDT- 2026/08/26 05:40 PHST- 2026/06/16 00:00 [received] PHST- 2026/08/02 00:00 [revised] PHST- 2026/08/12 00:00 [accepted] PHST- 2026/08/26 11:51 [medline] PHST- 2026/08/26 11:50 [pubmed] PHST- 2026/08/26 05:40 [entrez] PHST- 2026/08/24 00:00 [pmc-release] AID - 10.1177_27550834261483633 [pii] AID - 10.1177/27550834261483633 [doi] PST - epublish SO - J Med Access. 2026 Aug 24;10:27550834261483633. doi: 10.1177/27550834261483633. eCollection 2026 Jan-Dec. PMID- 42643340 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260827 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Identifying critical windows for macrosomia prevention: a study on the association between phase-specific dynamic BMI changes and macrosomia risk. PG - 1875915 LID - 10.3389/fendo.2026.1875915 [doi] LID - 1875915 AB - OBJECTIVE: To examine the correlation among pre-pregnancy body mass index (BMI), BMI increments during different gestational periods, and the occurrence of macrosomia in singleton full-term pregnant women without complications. Additionally, we aimed to assess the predictive performance of these BMI-related indicators for macrosomia, thereby identifying key time windows for targeted gestational weight management. METHODS: An analytical approach was adopted, entailing a retrospective evaluation of clinical data from 4,218 pregnant women without complications who underwent regular prenatal examinations and singleton full-term delivery during the period between January 2019 and December 2025 at the Jinshan Branch of Shanghai Sixth People's Hospital. Based on neonatal birth weight, a case-control design was employed, selecting 200 cases of macrosomia (macrosomia group) and 250 cases of normal birth weight infants (control group). Data including pre-pregnancy BMI, baseline BMI at the first prenatal visit (10-13 weeks), and BMI at various stages of mid- and late-pregnancy (20, 24, 28, 32, 36 weeks, and before delivery) were collected to calculate BMI increments for each stage. The predictive efficacy of individual BMI indicators and a combined model for macrosomia was evaluated using independent sample t-tests, Pearson correlation analysis (PCA), and receiver operating characteristic (ROC) curves. RESULTS: (1) Increased pre-pregnancy BMI was significantly and positively correlated with an increased macrosomia risk. Pre-pregnancy overweight (OR = 2.63) and obesity (OR = 9.06) emerged as independent risk contributors for macrosomia (P < 0.01). (2) Baseline BMI at 10-13 weeks, along with BMI increments during the 32-36 weeks period and the period from 36 weeks to delivery, exhibited a significant increase in the macrosomia group in comparison to the control group (P < 0.05). (3) The analysis of correlation demonstrated a moderate positive correlation between baseline BMI at 10-13 weeks and neonatal birth weight (r = 0.386, P < 0.001). However, no significant correlation was identified between mid-pregnancy BMI increments and birth weight (P > 0.05). (4) Utilising ROC curve analysis, it was ascertained that baseline BMI at 10-13 weeks exhibited the most optimal predictive efficacy among the individual indicators (AUC = 0.73), with the late-pregnancy increment indicators following in succession. The combined predictive model, integrating early-pregnancy BMI and late-pregnancy BMI increments, achieved a superior AUC of 0.84. CONCLUSION: Pre-pregnancy BMI, early-pregnancy (10-13 weeks) BMI, and late-pregnancy (32 weeks to delivery) BMI increments are critical predictors of macrosomia in pregnant women without complications. Specifically, baseline BMI at 10-13 weeks serves as a core indicator for early risk identification. Clinical interventions should focus on these two critical stages-early and late pregnancy-to implement individualized weight management, thereby effectively reducing the incidence of macrosomia and improving maternal and neonatal outcomes. CI - Copyright (c) 2026 Qu and Zhou. FAU - Qu, Huiling AU - Qu H AD - Department of Obstetrics and Gynecology, Jinshan Branch of Shanghai Sixth People's Hospital, Shanghai, China. FAU - Zhou, Yanna AU - Zhou Y AD - Department of Obstetrics and Gynecology, Jinshan Branch of Shanghai Sixth People's Hospital, Shanghai, China. LA - eng PT - Journal Article DEP - 20260811 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - Female MH - *Fetal Macrosomia/prevention & control/epidemiology/etiology MH - Pregnancy MH - *Body Mass Index MH - Retrospective Studies MH - Adult MH - Case-Control Studies MH - Birth Weight MH - Risk Factors MH - Infant, Newborn MH - China/epidemiology MH - *Gestational Weight Gain MH - Gestational Age PMC - PMC13503171 OTO - NOTNLM OT - BMI increment OT - gestational BMI OT - macrosomia OT - pre-pregnancy body mass index (BMI) OT - pregnancy outcomes OT - weight management COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/26 11:50 MHDA- 2026/08/26 11:51 PMCR- 2026/08/11 CRDT- 2026/08/26 05:09 PHST- 2026/05/08 00:00 [received] PHST- 2026/07/08 00:00 [revised] PHST- 2026/07/28 00:00 [accepted] PHST- 2026/08/26 11:51 [medline] PHST- 2026/08/26 11:50 [pubmed] PHST- 2026/08/26 05:09 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - 10.3389/fendo.2026.1875915 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Aug 11;17:1875915. doi: 10.3389/fendo.2026.1875915. eCollection 2026. PMID- 42643055 OWN - NLM STAT- Publisher LR - 20260826 IS - 1941-2452 (Electronic) IS - 0884-5336 (Linking) DP - 2026 Aug 26 TI - Parents'/Caregivers' perspectives on weight management in children with cystic fibrosis receiving modulator therapy: A cross-sectional survey. LID - 10.1002/ncp.70173 [doi] AB - BACKGROUND: Modulator therapy in children with cystic fibrosis (cwCF) has improved lung function and digestive health, prompting changes in nutrition management strategies for many cwCF. The purpose of this study is to describe parents'/caregivers' perspectives on weight management in cwCF with the introduction of cystic fibrosis transmembrane conductance regulator modulator therapies (CFTRm). METHODS: Researchers developed a cross-sectional survey regarding parents'/caregivers' perceptions of weight management in cwCF. Content validity was established through four expert reviews and two cognitive interviews. A link to the survey was posted on two private Facebook pages with members who attended a CF clinic in the western United States and distributed to families attending a CF clinic in the southeastern United States. Survey responses were analyzed with descriptive statistics. RESULTS: Forty-nine parents/caregivers represented data for 60 cwCF. Sixty cwCF were prescribed CFTRm, and 46 (76.6%) had taken CFTRm for more than a year. Forty-nine (86%) parents/caregivers agreed with clinicians on the weight classification of their cwCF. Many (52%) cwCF who received CFTRm for more than a year made changes to their diet. Parents/caregivers reported a mean score of 8.31 +/- 2.47, with 10 being very comfortable talking with the clinic about their child's weight. CONCLUSION: Parents'/caregivers' perceptions of weight management in their cwCF varied. Nutrition strategy changes ranged from adding additional calories to decreasing calories and discontinuing supplemental nutrition after starting CFTRm. Individualized nutrition therapy is required in the era of CFTRm. Parents'/caregivers' concerns and perspectives about weight and diet are vital to assessing weight management. CI - (c) 2026 American Society for Parenteral and Enteral Nutrition. FAU - Bellini, Sarah Gunnell AU - Bellini SG AUID- ORCID: 0000-0002-6755-6201 AD - Nutrition, Dietetics, and Food Science Department, Brigham Young University, Provo, Utah, USA. FAU - Keiser, Kayla AU - Keiser K AD - Nutrition, Dietetics, and Food Science Department, Brigham Young University, Provo, Utah, USA. FAU - Christenson, Makenzie AU - Christenson M AD - Clinical Nutrition Department and Cystic Fibrosis Center, Arkansas Children's Northwest, Springdale, Arkansas, USA. FAU - Coe, TrudyAnne AU - Coe T AD - Nutrition, Dietetics, and Food Science Department, Brigham Young University, Provo, Utah, USA. FAU - McDonald, Catherine M AU - McDonald CM AUID- ORCID: 0000-0003-3467-4663 AD - Primary Children's Hospital, Salt Lake City, Utah, USA. FAU - McRoberts, Madison AU - McRoberts M AD - Primary Children's Hospital, Salt Lake City, Utah, USA. FAU - Stoker, Jenna AU - Stoker J AD - Primary Children's Hospital, Salt Lake City, Utah, USA. LA - eng GR - This study was funded by Brigham Young University College of Life Sciences Grant./ PT - Journal Article DEP - 20260826 PL - United States TA - Nutr Clin Pract JT - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JID - 8606733 SB - IM OTO - NOTNLM OT - CFTR modulators OT - children OT - cystic fibrosis OT - disordered eating OT - nutrition management OT - weight management EDAT- 2026/08/26 05:36 MHDA- 2026/08/26 05:36 CRDT- 2026/08/26 03:22 PHST- 2026/07/28 00:00 [revised] PHST- 2026/02/13 00:00 [received] PHST- 2026/08/02 00:00 [accepted] PHST- 2026/08/26 05:36 [medline] PHST- 2026/08/26 05:36 [pubmed] PHST- 2026/08/26 03:22 [entrez] AID - 10.1002/ncp.70173 [doi] PST - aheadofprint SO - Nutr Clin Pract. 2026 Aug 26. doi: 10.1002/ncp.70173. PMID- 42642883 OWN - NLM STAT- Publisher LR - 20260907 IS - 2151-4658 (Electronic) IS - 2151-464X (Linking) DP - 2026 Aug 25 TI - Validation of Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Measures for Children With Chronic Nonbacterial Osteomyelitis. LID - 10.1002/acr.80146 [doi] AB - OBJECTIVE: To assess the validity of the Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric measures in patients with chronic nonbacterial osteomyelitis (CNO). METHODS: Within the longitudinal patient registry of CNO, English-speaking patients aged 8 years and older self-reported PROMIS Pediatric measures of fatigue, pain interference (PI), pain behavior (PB), mobility, upper extremity (UE), physical activity (PA), and strength impact (SI), and external validation measures. Log-transformed linear mixed-effects models with random patient intercepts were used to assess PROMIS T-score changes. Wilcoxon signed-rank test was performed to determine the PROMIS T-score changes among the improved, worsened, and unchanged groups. Spearman rank correlation test determined the relationship of PROMIS T-scores with disease status reported by patients/families. RESULTS: More than 1,000 clinical visits from 184 patients included PROMIS Pediatric measures entries. All PROMIS T-scores correlated significantly (P < 0.01) with patient-reported variables and physician global assessment (PHGA). The correlation between function and mobility, PB, and PI was good (r = 0.4-0.6). The correlation of patient-reported disease status was strong with PHGA (r = 0.75); moderate with mobility, PB, and PI; and weak with fatigue, SI, UE, and PA. The changes of PROMIS T-scores over time for mobility, PB, PA, and PI compared with the self-reported status change were significant (P < 0.05). After effective treatment, when clinical disease activity score improved by at least three points (n = 18), the change of PROMIS T-scores for mobility, PB, PI, and UE were significant (P < 0.05). CONCLUSION: This study provided evidence supporting the use of PROMIS Pediatric mobility, PB, and PI measures for CNO clinical disease monitoring. CI - (c) 2026 The Author(s). Arthritis Care & Research published by Wiley Periodicals LLC on behalf of American College of Rheumatology. FAU - Eckert, Mary M AU - Eckert MM AUID- ORCID: 0009-0000-2105-5025 AD - Western University of Health Sciences, Lebanon, Oregon. AD - Seattle Children's Hospital, Seattle, Washington. FAU - Wu, Eveline Y AU - Wu EY AUID- ORCID: 0000-0002-6394-6843 AD - The University of North Carolina at Chapel Hill. FAU - Oliver, Melissa AU - Oliver M AUID- ORCID: 0000-0002-7689-2573 AD - Indiana University School of Medicine, Indianapolis. FAU - Scheck, Joshua AU - Scheck J AD - Seattle Children's Hospital, Seattle, Washington. FAU - Lapidus, Sivia AU - Lapidus S AUID- ORCID: 0000-0001-8452-9937 AD - Joseph M. Sanzari Children's Hospital, Hackensack, New Jersey. AD - Hackensack University Medical Center, Hackensack, New Jersey. AD - Hackensack Meridian School of Medicine, Hackensack, New Jersey. FAU - Akca, Ummusen Kaya AU - Akca UK AUID- ORCID: 0000-0002-0426-9432 AD - Hacettepe University, Pediatric Rheumatology, Ankara, Turkey. FAU - Yasin, Shima AU - Yasin S AD - University of Iowa Carver College of Medicine, Iowa City. FAU - Lenert, Aleksander AU - Lenert A AUID- ORCID: 0000-0003-2129-3263 AD - University of Iowa Carver College of Medicine, Iowa City. FAU - Stern, Sara AU - Stern S AD - University of Utah, Salt Lake City. FAU - Insalaco, Antonella AU - Insalaco A AD - IRCCS Ospedale Pediatrico Bambino Gesu, Rheumatology, Rome, Italy. AD - ERN RITA Center, Rheumatology, Rome, Italy. FAU - Pardeo, Manuela AU - Pardeo M AUID- ORCID: 0000-0003-0850-7351 AD - IRCCS Ospedale Pediatrico Bambino Gesu, Rheumatology, Rome, Italy. AD - ERN RITA Center, Rheumatology, Rome, Italy. FAU - Simonini, Gabriele AU - Simonini G AD - AOU Meyer Children's Hospital, Rheumatology, Florence, Italy. AD - ERN ReCONNET Center, Rheumatology, Florence, Italy. FAU - Marrani, Edoardo AU - Marrani E AD - AOU Meyer Children's Hospital, Rheumatology, Florence, Italy. FAU - Wang, Xing AU - Wang X AD - Seattle Children's Research Institute, Seattle, Washington. FAU - Huang, Bin AU - Huang B AUID- ORCID: 0000-0001-9724-675X AD - Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio. AD - University of Cincinnati College of Medicine, Cincinnati, Ohio. FAU - Kovalick, Leonard K AU - Kovalick LK AD - The University of North Carolina at Chapel Hill. FAU - Rosenwasser, Natalie AU - Rosenwasser N AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Balay-Destrude, Erin AU - Balay-Destrude E AUID- ORCID: 0000-0001-6235-1947 AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Casselman, Gabriel AU - Casselman G AUID- ORCID: 0000-0001-6950-7502 AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Liau, Adriel AU - Liau A AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Klein, Ava AU - Klein A AD - Seattle Children's Hospital, Seattle, Washington. FAU - Shao, Yurong AU - Shao Y AD - Seattle Children's Hospital, Seattle, Washington. FAU - Yang, Claire AU - Yang C AUID- ORCID: 0000-0001-6822-0518 AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Briggs, Molly AU - Briggs M AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Mueller, Ethan AU - Mueller E AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Deng, Emily AU - Deng E AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Trunnell, Paige Rhiannon AU - Trunnell PR AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Hamilton, Iris AU - Hamilton I AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Machrone, Elise AU - Machrone E AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. FAU - Mosa, Doaa Mosad AU - Mosa DM AD - Mansoura University Hospitals, Rheumatology, Rehabilitation, Mansoura, Egypt. AD - Mansoura University, Rheumatology, Rehabilitation, Mansoura, Egypt. FAU - Tucker, Lori AU - Tucker L AUID- ORCID: 0000-0002-4314-6750 AD - BC Children's Hospital, Rheumatology, Vancouver, British Columbia, Canada. AD - University of British Columbia, Rheumatology, Vancouver, British Columbia, Canada. FAU - Girschick, Hermann AU - Girschick H AUID- ORCID: 0000-0002-2755-3129 AD - Vivantes Clinic Friedrichshain, Pediatrics, Berlin, Germany. FAU - Laxer, Ronald M AU - Laxer RM AD - The Hospital for Sick Children, Toronto, Ontario, Canada. AD - University of Toronto, Toronto, Ontario, Canada. AD - St Michael's Hospital, Toronto, Ontario, Canada. FAU - Tiller, Georgina AU - Tiller G AD - Royal Children's Hospital, Pediatrics, Melbourne, Victoria, Australia. FAU - Akikusa, Jonathan AU - Akikusa J AD - Royal Children's Hospital, Pediatrics, Melbourne, Victoria, Australia. FAU - Hedrich, Christian M AU - Hedrich CM AUID- ORCID: 0000-0002-1295-6179 AD - Alder Hey Children's NHS Foundation Trust, Department of Pediatric Rheumatology, Liverpool, United Kingdom. AD - Department of Women's and Children's Health, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, United Kingdom. FAU - Onel, Karen AU - Onel K AUID- ORCID: 0000-0002-1238-5361 AD - Hospital for Special Surgery, New York, New York. FAU - Dedeoglu, Fatma AU - Dedeoglu F AUID- ORCID: 0000-0002-7516-0848 AD - Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts. FAU - Twilt, Marinka AU - Twilt M AUID- ORCID: 0000-0003-1954-2822 AD - Department of Pediatrics, Section of Rheumatology, Alberta Children's Hospital, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. FAU - Ozen, Seza AU - Ozen S AUID- ORCID: 0000-0003-2883-7868 AD - Hacettepe University, Pediatric Rheumatology, Ankara, Turkey. FAU - Ferguson, Polly J AU - Ferguson PJ AD - University of Iowa Carver College of Medicine, Iowa City. FAU - Schanberg, Laura AU - Schanberg L AUID- ORCID: 0000-0002-1913-6472 AD - Duke Clinical Research Institute, Durham, North Carolina. AD - Duke University School of Medicine, Durham, North Carolina. FAU - Reeve, Bryce B AU - Reeve BB AUID- ORCID: 0000-0002-6709-8714 AD - Duke Clinical Research Institute, Durham, North Carolina. AD - Duke University School of Medicine, Durham, North Carolina. FAU - Zhao, Yongdong AU - Zhao Y AUID- ORCID: 0000-0003-3618-1379 AD - Seattle Children's Hospital, Seattle, Washington. AD - University of Washington, Seattle. LA - eng GR - Kaila Komfort/ PT - Journal Article DEP - 20260825 PL - United States TA - Arthritis Care Res (Hoboken) JT - Arthritis care & research JID - 101518086 SB - IM EDAT- 2026/08/26 05:36 MHDA- 2026/08/26 05:36 CRDT- 2026/08/26 01:02 PHST- 2026/07/27 00:00 [revised] PHST- 2025/11/20 00:00 [received] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/26 05:36 [pubmed] PHST- 2026/08/26 05:36 [medline] PHST- 2026/08/26 01:02 [entrez] AID - 10.1002/acr.80146 [doi] PST - aheadofprint SO - Arthritis Care Res (Hoboken). 2026 Aug 25. doi: 10.1002/acr.80146. PMID- 42642695 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20260924 IS - 1996-9805 (Electronic) IS - 1818-6300 (Print) IS - 1818-6300 (Linking) VI - 27 IP - 5 DP - 2026 Oct TI - Dental erosion and erosive tooth wear in childhood and adolescence: from diagnosis to prevention. PG - 1317-1333 LID - 10.1007/s40368-026-01233-8 [doi] AB - BACKGROUND: Dental erosion and erosive tooth wear (ETW) are increasingly significant non-carious defects in industrialized countries. Reasons for an increased prevalence are mainly modern dietary habits, but an improved diagnostic awareness also contributes to an apparent increase in cases. Unlike caries, erosion involves acid-induced demineralization without bacterial involvement. When this is combined with mechanical wear, it results in ETW. Diagnosis commonly employs the Basic Erosive Wear Examination (BEWE), a standardized clinical index assessing lesion severity across sextants. ETIOLOGY AND SUSCEPTIBILITY FACTORS: Primary teeth might be more susceptible to ETW due to thinner and less mineralized enamel with lower microhardness, and dentine with a higher carbonate content and higher tubule density. Longer acid exposures increase their demineralization rates compared to permanent teeth. The salivary pellicle offers variable protection, with children's saliva showing distinct composition and efficacy. Key risk factors include frequent consumption of acidic beverages, certain medications, gastroesophageal reflux, and certain behavioral habits. Genetic, salivary, and lifestyle factors further modulate individual susceptibility. PREVENTION: Preventive strategies emphasize risk assessment, dietary modification, and chemical protection using different fluoride-based agents, which form acid-resistant surface layers reducing enamel and dentine solubility. Combinations with chitosan or other polymers may enhance protection. Novel approaches include bio-inspired and film-forming agents, pellicle modification with proteins (e.g., CaneCPI-5), and natural polyphenols that reinforce acid resistance and collagen stability. While laboratory and in situ studies support these strategies, long-term clinical validation remains limited. CONCLUSIONS: Comprehensive management of ETW should integrate early diagnosis, patient education, and multi-modal prevention, particularly targeting children and adolescents, where susceptibility and long-term consequences are greatest. CI - (c) 2026. The Author(s). FAU - Carvalho, T S AU - Carvalho TS AD - School of Dental Medicine, Department of Restorative, Preventive and Pediatric Dentistry, University of Bern, Bern, Switzerland. FAU - Baumann, T AU - Baumann T AD - School of Dental Medicine, Department of Restorative, Preventive and Pediatric Dentistry, University of Bern, Bern, Switzerland. tommy.baumann@unibe.ch. FAU - Niemeyer, S H AU - Niemeyer SH AD - School of Dental Medicine, Department of Restorative, Preventive and Pediatric Dentistry, University of Bern, Bern, Switzerland. FAU - Buzalaf, M A R AU - Buzalaf MAR AD - Bauru School of Dentistry, University of Sao Paulo, Bauru, Brazil. FAU - Lingstrom, P AU - Lingstrom P AD - Institute of Odontology, Department of Cariology, University of Gothenburg, Gothenburg, Sweden. FAU - Lussi, A AU - Lussi A AD - School of Dental Medicine, Department of Restorative, Preventive and Pediatric Dentistry, University of Bern, Bern, Switzerland. AD - University Hospital for Conservative Dentistry and Periodontology, Medical University of Innsbruck, Innsbruck, Austria. AD - University Medical Centre, Department of Operative Dentistry and Periodontology, University of Freiburg, Freiburg, Germany. LA - eng PT - Journal Article PT - Review DEP - 20260825 PL - England TA - Eur Arch Paediatr Dent JT - European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry JID - 101277157 SB - IM MH - Humans MH - *Tooth Erosion/diagnosis/prevention & control/etiology MH - Child MH - Adolescent MH - Risk Factors MH - *Tooth Wear/prevention & control/diagnosis/etiology MH - Fluoride Treatment PMC - PMC13593698 OTO - NOTNLM OT - Adolescence OT - Childhood OT - Erosion OT - Erosive tooth wear OT - Prevention COIS- Declarations. Conflict of interest: The authors declare no competing interests. EDAT- 2026/08/26 05:36 MHDA- 2026/09/21 17:47 PMCR- 2026/08/25 CRDT- 2026/08/26 00:14 PHST- 2025/12/16 00:00 [received] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/09/21 17:47 [medline] PHST- 2026/08/26 05:36 [pubmed] PHST- 2026/08/26 00:14 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.1007/s40368-026-01233-8 [pii] AID - 1233 [pii] AID - 10.1007/s40368-026-01233-8 [doi] PST - ppublish SO - Eur Arch Paediatr Dent. 2026 Oct;27(5):1317-1333. doi: 10.1007/s40368-026-01233-8. Epub 2026 Aug 25. PMID- 42642511 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260828 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Aug 25 TI - The relationship between problematic media use and their fear, anxiety and behavior during dental treatment in children. LID - 10.1038/s41598-026-63546-4 [doi] LID - 26663 AB - This study aimed to investigate individual, familial, and media-related factors associated with dental fear and anxiety (DFA) and dental behavior management problems (DBMP) in school-age children, with particular emphasis on problematic media use (PMU). In this cross-sectional study, 145 children aged 6-12 years undergoing restorative dental treatment were evaluated. Sociodemographic characteristics, maternal dental anxiety, children's media use characteristics, and PMU were assessed using parental questionnaires and the Problematic Media Use Measure-Short Form (PMUM-SF). Children's dental fear and anxiety were assessed using validated child questionnaires, namely the Children's Fear Survey Schedule-Dental Subscale (CFSS-DS) and the Modified Child Dental Anxiety Scale (MCDASf), while behavior during dental treatment was assessed using the standardized Frankl Rating Scale (FRS). Group comparisons, correlation analyses, and multivariable logistic regression analyses were performed. Dental anxiety and uncooperative behavior during dental treatment were more common among early school-age children than pre-teens (p = 0.011 and p = 0.002, respectively). Maternal dental anxiety was independently associated with uncooperative behavior during dental treatment (AOR = 2.93, 95% CI:1.36-6.30) and dental fear (AOR = 2.86, 95% CI:1.38-5.94). PMUM-SF scores did not differ significantly between children with and without dental anxiety in unadjusted analyses. However, after adjustment for potential confounders, higher PMUM-SF scores were independently associated with dental fear (AOR = 1.07, 95% CI:1.01-1.13). The observed correlations between PMUM-SF scores and dental anxiety-related measures were statistically significant but weak. Younger age and maternal dental anxiety were among the factors most consistently associated with children's dental fear and behavior. Although PMU showed only weak associations with dental anxiety-related outcomes, higher PMUM-SF scores were independently associated with dental fear after adjustment for potential confounders. These findings should be interpreted cautiously and considered exploratory given the cross-sectional design and modest effect sizes. CI - (c) 2026. The Author(s). FAU - Mustuloglu, Seyma AU - Mustuloglu S AUID- ORCID: 0000-0001-9796-4348 AD - Department of Paediatric Dentistry, Faculty of Dentistry, Mersin University, Mersin, Turkey. dtseymaozturk@gmail.com. FAU - Tezol, Ozlem AU - Tezol O AUID- ORCID: 0000-0001-9994-7832 AD - Department of Pediatrics, Faculty of Medicine, Mersin University, Mersin, Turkey. FAU - Yalcin, Siddika Songul AU - Yalcin SS AUID- ORCID: 0000-0001-9061-4281 AD - Department of Social Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Turkey. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260825 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Child MH - Female MH - *Dental Anxiety/psychology/epidemiology MH - Male MH - Cross-Sectional Studies MH - *Child Behavior/psychology MH - Surveys and Questionnaires MH - Media Exposure PMC - PMC13507237 OTO - NOTNLM OT - Behavior Management Problems OT - Children OT - Dental Fear and Anxiety OT - Problematic Media Use OT - Screen Time COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: Mersin University Non-Interventional Clinical Research Ethics Committee's (2022/740) approval was obtained. EDAT- 2026/08/26 05:36 MHDA- 2026/08/26 05:37 PMCR- 2026/08/25 CRDT- 2026/08/25 23:56 PHST- 2026/04/02 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/08/26 05:37 [medline] PHST- 2026/08/26 05:36 [pubmed] PHST- 2026/08/25 23:56 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.1038/s41598-026-63546-4 [pii] AID - 63546 [pii] AID - 10.1038/s41598-026-63546-4 [doi] PST - epublish SO - Sci Rep. 2026 Aug 25;16(1):26663. doi: 10.1038/s41598-026-63546-4. PMID- 42642452 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260828 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Aug 25 TI - E-healthy diet literacy is associated with psychological well-being and diet-related risk behaviors among university students in Turkiye: a cross-sectional study. LID - 10.1038/s41598-026-68297-w [doi] LID - 26673 AB - E-healthy diet literacy is the ability to find, understand, appraise, and apply online healthy-eating information. We examined its associations with psychological well-being and diet-related risk behaviors in a cross-sectional convenience sample of 331 undergraduates aged 18-26 years in Ankara, Turkiye; 84.9% were female. Participants completed the e-Healthy Diet Literacy Questionnaire (e-HDLQ), World Health Organization-Five Well-Being Index (WHO-5), and Eating Habits Index (EHI). Associations were modeled using multivariable linear regression and an exploratory covariate-adjusted path analysis with 5,000 bootstrap resamples. After multivariable adjustment, higher e-HDLQ scores were associated with higher WHO-5 scores (unstandardized B = 0.443; standardized beta = 0.179; 95% confidence interval [CI] for B, 0.174 to 0.713; p = 0.001) and, in a model additionally including WHO-5, with lower EHI scores (B = - 0.123; beta = -0.281; 95% CI for B, - 0.171 to - 0.075; p < 0.001). A one-standard-deviation higher e-HDLQ score was associated with a WHO-5 score 3.38 percentage points higher and an EHI score 0.94 points lower. The bias-corrected 95% CI for the indirect component through WHO-5 included zero. Associations were modest; the EHI estimate warrants cautious interpretation because internal consistency was low (Cronbach's alpha = 0.56). Concurrent measurement does not establish temporal ordering or causality. CI - (c) 2026. The Author(s). FAU - Tuncer, Esra AU - Tuncer E AUID- ORCID: 0000-0001-7151-842X AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Bolu Abant Izzet Baysal University, Bolu, Turkey. FAU - Duman, Emre AU - Duman E AUID- ORCID: 0000-0002-8956-2696 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Siirt University, Siirt, Turkey. emre.duman@siirt.edu.tr. FAU - Sahin Bodur, Gulsum AU - Sahin Bodur G AUID- ORCID: 0000-0001-7450-0428 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Cankiri Karatekin University, Cankiri, Turkey. FAU - Keser, Alev AU - Keser A AUID- ORCID: 0000-0003-2620-6747 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Ankara University, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260825 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - *Students/psychology MH - Universities MH - Young Adult MH - Adolescent MH - Psychological Well-Being MH - Male MH - Adult MH - *Diet, Healthy/psychology MH - *Health Literacy MH - Surveys and Questionnaires MH - Feeding Behavior/psychology MH - Turkey MH - *Risk-Taking PMC - PMC13507282 OTO - NOTNLM OT - Diet-related risk behaviors OT - Path analysis OT - Psychological well-being OT - University students OT - e-healthy diet literacy COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval: All procedures were conducted in accordance with the Declaration of Helsinki and were approved by the Ankara University Ethics Committee (Date: 25/04/2024; No: 07/62). Written informed consent was obtained from all participants before data collection. Declaration of generative AI and AI-assisted technologies in the manuscript preparation process: During manuscript preparation, DeepL and ChatGPT were used for English-language editing and translation from Turkish. All outputs were reviewed and revised by the authors, who take responsibility for the final text. EDAT- 2026/08/26 05:36 MHDA- 2026/08/26 05:37 PMCR- 2026/08/25 CRDT- 2026/08/25 23:46 PHST- 2026/07/11 00:00 [received] PHST- 2026/08/20 00:00 [accepted] PHST- 2026/08/26 05:37 [medline] PHST- 2026/08/26 05:36 [pubmed] PHST- 2026/08/25 23:46 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - 10.1038/s41598-026-68297-w [pii] AID - 68297 [pii] AID - 10.1038/s41598-026-68297-w [doi] PST - epublish SO - Sci Rep. 2026 Aug 25;16(1):26673. doi: 10.1038/s41598-026-68297-w. PMID- 42641818 OWN - NLM STAT- MEDLINE DCOM- 20260906 LR - 20260906 IS - 1874-1754 (Electronic) IS - 0167-5273 (Linking) VI - 463 DP - 2026 Nov 15 TI - Tracking arterial stiffness from childhood to adolescence: the role of adiposity and cardiometabolic factors. PG - 134754 LID - S0167-5273(26)00604-2 [pii] LID - 10.1016/j.ijcard.2026.134754 [doi] AB - BACKGROUND: Carotid-femoral pulse wave velocity (PWV) is the gold standard measure of central arterial stiffness and a predictor of cardiovascular events in adults, with growing relevance in pediatric populations. Although PWV increases naturally with age, cardiometabolic risk factors may accelerate this process. This study compared carotid-femoral PWV between non-overweight and overweight/obese adolescents, evaluated its progression from prepubertal age to early adolescence, and identified independent determinants of arterial stiffness. METHODS: This longitudinal study included 118 participants from the Generation XXI cohort (Porto, Portugal) assessed at ages 8-9 and 13-14 years. Carotid-femoral PWV was measured at both time points using a validated portable device. Anthropometric data, office blood pressure, and fasting blood samples for lipid profile, glucose, and insulin were collected. Body mass index (BMI) classification followed World Health Organization references. RESULTS: PWV increased significantly from childhood to adolescence (5.01 +/- 0.47 to 6.30 +/- 1.05 m/s; p < 0.001). At 13-14 years, overweight/obese adolescents had significantly higher PWV than non-overweight peers. PWV at 13-14 years correlated positively with BMI, BMI z-score, systolic and diastolic blood pressure, and fasting glucose. In adjusted models, PWV at 8-9 years (beta = 0.39; p = 0.039) and BMI z-score at 13-14 years (beta = 0.33; p < 0.001) remained independent predictors of PWV at 13-14 years. CONCLUSIONS: Arterial stiffness in early adolescence reflects both vascular tracking from childhood and concurrent adiposity. These findings support early vascular screening and weight management interventions during key developmental periods to optimize long-term cardiovascular health. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Ventura, Daniela AU - Ventura D AD - Instituto de Ciencias Biomedicas de Abel Salazar, University of Porto, Portugal. FAU - Mosca, Sara AU - Mosca S AD - Instituto de Ciencias Biomedicas de Abel Salazar, University of Porto, Portugal; EPIUnit ITR, Instituto de Saude Publica da Universidade do Porto, University of Porto, Portugal; Pediatric Nephrology Department, Centro Materno-Infantil do Norte, ULS Santo Antonio, Portugal. FAU - Teixeira, Ana AU - Teixeira A AD - EPIUnit ITR, Instituto de Saude Publica da Universidade do Porto, University of Porto, Portugal; Pediatric Nephrology Department, Centro Materno-Infantil do Norte, ULS Santo Antonio, Portugal. FAU - Mota, Claudia AU - Mota C AD - Pediatric Cardiology Department, ULS Sao Joao, Portugal. FAU - Costa, Ana Luisa AU - Costa AL AD - Pediatric Cardiology Department, ULS Sao Joao, Portugal. FAU - Caldas Afonso, Alberto AU - Caldas Afonso A AD - Instituto de Ciencias Biomedicas de Abel Salazar, University of Porto, Portugal; EPIUnit ITR, Instituto de Saude Publica da Universidade do Porto, University of Porto, Portugal; Pediatric Nephrology Department, Centro Materno-Infantil do Norte, ULS Santo Antonio, Portugal. FAU - Correia-Costa, Liane AU - Correia-Costa L AD - Instituto de Ciencias Biomedicas de Abel Salazar, University of Porto, Portugal; EPIUnit ITR, Instituto de Saude Publica da Universidade do Porto, University of Porto, Portugal; Pediatric Nephrology Department, Centro Materno-Infantil do Norte, ULS Santo Antonio, Portugal. Electronic address: lianecosta@icbas.up.pt. LA - eng PT - Journal Article DEP - 20260825 PL - Netherlands TA - Int J Cardiol JT - International journal of cardiology JID - 8200291 SB - IM MH - Humans MH - *Vascular Stiffness/physiology MH - Child MH - Adolescent MH - Female MH - Male MH - Longitudinal Studies MH - *Adiposity/physiology MH - *Cardiometabolic Risk Factors MH - Pulse Wave Analysis/methods MH - Cohort Studies MH - *Cardiovascular Diseases/physiopathology/epidemiology MH - Carotid-Femoral Pulse Wave Velocity/methods MH - Portugal/epidemiology MH - Body Mass Index OTO - NOTNLM OT - Adolescence OT - Arterial stiffness OT - Cardiovascular risk OT - Childhood obesity OT - Pulse wave velocity COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/25 23:33 MHDA- 2026/09/06 23:34 CRDT- 2026/08/25 19:12 PHST- 2026/06/20 00:00 [received] PHST- 2026/08/22 00:00 [revised] PHST- 2026/08/24 00:00 [accepted] PHST- 2026/09/06 23:34 [medline] PHST- 2026/08/25 23:33 [pubmed] PHST- 2026/08/25 19:12 [entrez] AID - S0167-5273(26)00604-2 [pii] AID - 10.1016/j.ijcard.2026.134754 [doi] PST - ppublish SO - Int J Cardiol. 2026 Nov 15;463:134754. doi: 10.1016/j.ijcard.2026.134754. Epub 2026 Aug 25. PMID- 42641368 OWN - NLM STAT- MEDLINE DCOM- 20260831 LR - 20260918 IS - 1532-3099 (Electronic) IS - 0266-6138 (Linking) VI - 162 DP - 2026 Nov TI - Exploring the dose-response relationship between prenatal exercise and postpartum depression: A systematic review and meta-analysis of randomized controlled trials. PG - 104960 LID - S0266-6138(26)00264-0 [pii] LID - 10.1016/j.midw.2026.104960 [doi] AB - IMPORTANCE: Postpartum depression (PPD) is a hidden and widespread global public health crisis affecting millions of mothers and infants annually. Prenatal exercise is a potentially accessible nonpharmacological strategy for PPD prevention, but its optimal dose remains uncertain. OBJECTIVE: To explore the dose-response relationship between prenatal exercise and the incidence of PPD through meta-analysis of randomized controlled trials (RCTs). DATA SOURCES: Systematic searches were conducted in PubMed, Embase, Web of Science, and Cochrane Library using MeSH terms and keywords related to "pregnant women," "prenatal exercise," and "postpartum depression," up to June 23, 2025. STUDY SELECTION: RCTs included examined prenatal exercise interventions in pregnant women without a history of depression, with PPD incidence reported using validated depression scales (such as EPDS, CES-D). Non-RCT studies, duplicate publications, and studies with insufficient data were excluded. DATA EXTRACTION AND SYNTHESIS: Two researchers independently extracted data according to the PRISMA guidelines. A random-effects model was used to pool odds ratios (OR) and their 95% confidence intervals (CI). Linear and nonlinear dose-response models were employed to analyze and evaluate the relationship between exercise dose (measured in METs-min/week) and the incidence of PPD. MAIN OUTCOME(S) AND MEASURE(S): The primary outcome is the incidence of PPD, analyzing its relationship with prenatal exercise dose. RESULTS: Eight RCTs involving 2231 pregnant women were included. The pooled analysis showed that prenatal exercise was associated with a potential reduction in PPD incidence, although the overall effect did not reach statistical significance (OR=0.58, 95% CI [0.33, 1.02]). In dose-stratified analysis, exercise doses >/=500 METs-min/week were associated with significantly lower PPD incidence (OR=0.44, 95% CI [0.24, 0.78]). Subgroup analyses suggested trends toward greater benefits among women aged >/=30 years and those initiating exercise between 14 and 28 weeks of gestation; however, subgroup differences did not reach statistical significance. The linear dose-response trend did not reach statistical significance (p = 0.0533), and neither the overall spline association (p = 0.1704) nor the test for nonlinearity (p = 0.6361) was statistically significant. CONCLUSIONS AND RELEVANCE: Prenatal exercise may be associated with a lower risk of PPD, but the overall pooled effect did not reach statistical significance. Findings concerning >/=500 METs-min/week and the apparent flattening of the dose-response curve should be considered exploratory and require confirmation in larger trials. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Lei, Zhuoling AU - Lei Z AD - School of Physical Education, Southwest University, Chongqing 400715, China; Institute of Motor Quotient, Southwest University, Chongqing 400715, China. FAU - Ma, Pengwei AU - Ma P AD - School of Physical Education, Southwest University, Chongqing 400715, China; Institute of Motor Quotient, Southwest University, Chongqing 400715, China. FAU - Xue, Zhuolin AU - Xue Z AD - School of Physical Education, Southwest University, Chongqing 400715, China; Institute of Motor Quotient, Southwest University, Chongqing 400715, China. FAU - Teo, Eng Wah AU - Teo EW AD - Faculty of Sports and Exercise Science, University of Malaya, Kuala Lumpur 59100, Malaysia. FAU - Li, Junfeng AU - Li J AD - Ministry of Sports, Shandong Technology and Business University, Yantai, 264005, China. Electronic address: 201513386@sdtbu.edu.cn. FAU - Chang, Jindong AU - Chang J AD - School of Physical Education, Southwest University, Chongqing 400715, China; Institute of Motor Quotient, Southwest University, Chongqing 400715, China; Faculty of Sports and Exercise Science, University of Malaya, Kuala Lumpur 59100, Malaysia. Electronic address: changlai@163.com. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260820 PL - Scotland TA - Midwifery JT - Midwifery JID - 8510930 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Randomized Controlled Trials as Topic MH - *Depression, Postpartum/prevention & control/psychology MH - *Exercise/psychology MH - *Prenatal Care/methods/standards OTO - NOTNLM OT - Depression OT - METs OT - Meta-analysis OT - Postpartum depression OT - Prenatal exercise COIS- Declaration of competing interest All authors declare no conflict of interest. EDAT- 2026/08/25 23:33 MHDA- 2026/08/31 23:43 CRDT- 2026/08/25 18:06 PHST- 2025/09/04 00:00 [received] PHST- 2026/08/13 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/08/31 23:43 [medline] PHST- 2026/08/25 23:33 [pubmed] PHST- 2026/08/25 18:06 [entrez] AID - S0266-6138(26)00264-0 [pii] AID - 10.1016/j.midw.2026.104960 [doi] PST - ppublish SO - Midwifery. 2026 Nov;162:104960. doi: 10.1016/j.midw.2026.104960. Epub 2026 Aug 20. PMID- 42641101 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260825 IS - 1998-3905 (Electronic) IS - 0970-4388 (Linking) VI - 44 IP - 4 DP - 2026 Jul 1 TI - Efficacy of high-speed extraoral bitewing versus intraoral bitewing and panoramic for proximal caries in primary molars: A histological validation study. PG - 471-481 LID - 10.4103/jisppd.jisppd_162_26 [doi] AB - INTRODUCTION: Detecting proximal caries in primary teeth is challenging. While intraoral bitewing radiography (IOBW) is the standard for proximal caries assessment, it faces limitations in pediatric patients. Extraoral bitewing radiography (EOBW) addresses these limitations by capturing bilateral posterior dentition within a single exposure. AIMS: The aim of the study was to evaluate the diagnostic efficacy of EOBW (high-speed [HS] and standard [SD] modes) in detecting proximal caries in primary molars compared to IOBW and panoramic radiography (PR), using histological examination as the reference standard. MATERIALS AND METHODS: Fifty-six extracted primary molars, with and without proximal dental caries, were randomly arranged in the 3D-printed skull and mandible. Four radiographic modalities were evaluated: IOBW using size #0 photostimulable phosphor plates, and EOBW-HS, EOBW-SD, and PR using a digital panoramic X-ray unit. Two observers independently graded caries twice at one-week intervals. Scores were compared with the histological reference standard. RESULTS: All modalities showed excellent intraobserver agreement (K > 0.8). For inter-observer agreement, all bitewing techniques demonstrated excellent agreement, whereas PR yielded the lowest. The Wilcoxon signed-rank test showed significant differences in caries grading scores between PR and all the other techniques. Area under the receiver operating characteristic curve indicated good diagnostic value for cavitated dentin caries across all modalities. EOBW demonstrated the highest sensitivity for detecting proximal caries in dentin. CONCLUSIONS: EOBW and IOBW provide comparable radiographic grading across all caries depths. EOBW-HS is an accurate alternative for detecting proximal dentin caries, particularly for pediatric patient's intolerant to intraoral radiography. However, caution should be exercised when enamel caries is suspected. CI - Copyright (c) 2026 Journal of Indian Society of Pedodontics and Preventive Dentistry. FAU - Tunthasen, Piyanuch AU - Tunthasen P AD - Department of Preventive Dentistry, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand. FAU - Tohnak, Sirilawan AU - Tohnak S AD - Department of Oral Diagnosis, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand. FAU - Naivikul, Supanya AU - Naivikul S AD - Department of Preventive Dentistry, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand. FAU - Chantaramanee, Ariya AU - Chantaramanee A AD - Department of Preventive Dentistry, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand. FAU - Sakulratchata, Ruedee AU - Sakulratchata R AD - Department of Preventive Dentistry, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand. FAU - Tunthasen, Rudjit AU - Tunthasen R AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand. FAU - Deepho, Chutamas AU - Deepho C AD - Department of Oral Diagnosis, Faculty of Dentistry, Naresuan University, Phitsanulok, Thailand. LA - eng PT - Comparative Study PT - Journal Article PT - Validation Study DEP - 20260825 PL - India TA - J Indian Soc Pedod Prev Dent JT - Journal of the Indian Society of Pedodontics and Preventive Dentistry JID - 8710631 SB - IM MH - Humans MH - *Dental Caries/diagnostic imaging/pathology MH - *Molar/diagnostic imaging/pathology MH - *Tooth, Deciduous/diagnostic imaging/pathology MH - *Radiography, Bitewing/methods MH - *Radiography, Panoramic/methods OTO - NOTNLM OT - Bitewing radiography OT - dental digital radiography OT - pediatric dentistry OT - proximal caries detection EDAT- 2026/08/25 17:35 MHDA- 2026/08/25 17:36 CRDT- 2026/08/25 15:36 PHST- 2026/04/04 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/08/25 17:36 [medline] PHST- 2026/08/25 17:35 [pubmed] PHST- 2026/08/25 15:36 [entrez] AID - 00005097-202607000-00016 [pii] AID - 10.4103/jisppd.jisppd_162_26 [doi] PST - ppublish SO - J Indian Soc Pedod Prev Dent. 2026 Jul 1;44(4):471-481. doi: 10.4103/jisppd.jisppd_162_26. Epub 2026 Aug 25. PMID- 42640944 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260904 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 8 DP - 2026 TI - Can different exercise modalities improve esports performance? Study protocol for a 12-week three-arm randomized controlled trial. PG - e0357119 LID - 10.1371/journal.pone.0357119 [doi] LID - e0357119 AB - BACKGROUND: Growing evidence indicates a positive association between physical exercise and both cognitive functions and gaming performance in esports players. However, most existing studies focus on acute or short-term effects and are limited by small sample sizes and a lack of follow-up assessments. Furthermore, comparisons between different exercise modalities remain largely unexplored. Therefore, longitudinal studies comparing optimal exercise protocols and their sustained effects on esports performance are critically needed. OBJECTIVE: This study aims to: (1) investigate and compare the long-term effects of 12-week high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on various dimensions of esports performance in first-person shooter (FPS) gamers; (2) examine the sustainability of these effects through a 4-week follow-up assessment; and (3) explore the potential associations between physical competence, psychological skills, and gaming performance. METHODS: In this three-arm randomized controlled trial, 195 FPS gamers (aged 18-29) will be randomly assigned to HIIT, MICT, or control groups. Interventions consist of three weekly sessions for 12 weeks (HIIT: 10 x 1-minute high-intensity bouts interspersed with 1-minute active recovery; MICT: 20-minute continuous moderate-intensity exercise). The primary outcome is flicking capacity (a core metric of esports performance). Secondary outcomes include other gaming operational metrics, esports-related psychological skills, body composition, and physical competence. All outcomes will be assessed at baseline, post-intervention (12 weeks), and follow-up (16 weeks). DISCUSSION: This protocol outlines a standardized longitudinal framework to address the critical lack of evidence-based esports training guidelines. Anticipated findings will further validate the benefits of physical exercise on esports performance, providing essential long-term empirical evidence for integrating optimal exercise modalities into esports training regimens. Furthermore, exploring the associations between physical competence, psychological skills, and operational performance will offer insights into the behavioral pathways of performance enhancement. TRIAL REGISTRATION: ClinicalTrials.gov (NCT07150312). Registered on Aug 29, 2025. CI - Copyright: (c) 2026 Tang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Tang, Di AU - Tang D AD - Department of Sports Science and Physical Education, Faculty of Education, The Chinese University of Hong Kong, Hong Kong, China. AD - The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China. FAU - Ye, Zheng AU - Ye Z AD - Department of Sports Science and Physical Education, Faculty of Education, The Chinese University of Hong Kong, Hong Kong, China. FAU - Ma, Ruisi AU - Ma R AD - School of Physical Education, Jinan University, Guangzhou, China. FAU - Liu, Jinde AU - Liu J AD - Faculty of Physical Education, Fudan University, Shanghai, China. FAU - Ho, Wai Keung AU - Ho WK AUID- ORCID: 0000-0003-0387-9869 AD - Department of Sports Science and Physical Education, Faculty of Education, The Chinese University of Hong Kong, Hong Kong, China. FAU - Sum, Raymond Kim Wai AU - Sum RKW AUID- ORCID: 0000-0002-4051-9945 AD - Department of Sports Science and Physical Education, Faculty of Education, The Chinese University of Hong Kong, Hong Kong, China. LA - eng SI - ClinicalTrials.gov/NCT07150312 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260825 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *High-Intensity Interval Training/methods MH - Young Adult MH - Adolescent MH - Male MH - Female MH - *Exercise/physiology MH - Research Design PMC - PMC13505923 COIS- The authors have declared that no competing interests exist. EDAT- 2026/08/25 17:35 MHDA- 2026/08/25 17:36 PMCR- 2026/08/25 CRDT- 2026/08/25 13:35 PHST- 2026/03/16 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/08/25 17:36 [medline] PHST- 2026/08/25 17:35 [pubmed] PHST- 2026/08/25 13:35 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - PONE-D-26-12376 [pii] AID - 10.1371/journal.pone.0357119 [doi] PST - epublish SO - PLoS One. 2026 Aug 25;21(8):e0357119. doi: 10.1371/journal.pone.0357119. eCollection 2026. PMID- 42640915 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260827 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 8 DP - 2026 TI - Circulating CTRP-1 levels are elevated in women with polycystic ovary syndrome: A case-control study. PG - e0356461 LID - 10.1371/journal.pone.0356461 [doi] LID - e0356461 AB - OBJECTIVE: To investigate circulating C1q/TNF-related protein-1 (CTRP-1) levels in women with polycystic ovary syndrome (PCOS) and evaluate its potential association with metabolic and reproductive features of the syndrome. METHODS: A prospective cross-sectional case-control study was conducted between October 2021 and March 2022 including 96 women (48 with PCOS and 48 controls) aged 15-40 years. PCOS was diagnosed according to the 2003 Rotterdam criteria. Anthropometric measurements and fasting venous blood samples were obtained during the early follicular phase. Serum CTRP-1 levels were measured using enzyme-linked immunosorbent assay (ELISA). Metabolic and hormonal parameters, including HOMA-IR, AMH, and androgen levels, were analyzed. Receiver operating characteristic (ROC) analysis and analysis of covariance (ANCOVA) adjusted for age and body mass index (BMI) were performed. RESULTS: Serum CTRP-1 levels were significantly higher in women with PCOS compared with controls (54.9 +/- 5.2 vs. 26.6 +/- 4.8 ng/mL, p < 0.001). CTRP-1 concentrations were associated with several metabolic and hormonal parameters, including BMI, fasting insulin, triglyceride levels, HDL cholesterol, and AMH. ROC curve analysis demonstrated excellent discriminatory ability within this cohort, although these findings should be interpreted cautiously given the relatively small sample size and case-control design. In multivariable analysis adjusting for age and BMI, CTRP-1 remained independently associated with PCOS (beta = 28.97, p < 0.001). CONCLUSION: Circulating CTRP-1 levels are elevated in women with PCOS and appear to be associated with both metabolic and reproductive characteristics of the syndrome. CTRP-1 may represent a potential biomarker related to metabolic dysregulation in PCOS; however, larger prospective and multicenter studies are required to validate its clinical and diagnostic utility. CI - Copyright: (c) 2026 Ali et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Ali, Cavide AU - Ali C AUID- ORCID: 0000-0001-6188-1516 AD - Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkiye. AD - Obstetrics and Gynecology Clinic, Kadikoy Acibadem Hospital, Istanbul, Turkey. FAU - Sayir, Alper AU - Sayir A AD - Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkiye. FAU - Ocba, Feride AU - Ocba F AD - Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkiye. FAU - Ozturk Atan, Deniz AU - Ozturk Atan D AD - Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkiye. FAU - Harmanci, Melike Sevde AU - Harmanci MS AUID- ORCID: 0000-0002-5629-2036 AD - Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkiye. FAU - Surecek, Mustafa Cem AU - Surecek MC AD - Department of Obstetrics and Gynecology, Canakkale Onsekiz Mart University, Canakkale, Turkiye. FAU - Gulerman, Hacer Cavidan AU - Gulerman HC AD - Department of Obstetrics and Gynecology, Ankara Bilkent City Hospital, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260825 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (C1QTNF1 protein, human) RN - 0 (Biomarkers) RN - 0 (Proteins) SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/blood MH - Case-Control Studies MH - Adult MH - Young Adult MH - Adolescent MH - Cross-Sectional Studies MH - Prospective Studies MH - Body Mass Index MH - ROC Curve MH - Biomarkers/blood MH - Proteins PMC - PMC13505912 COIS- The authors have declared that no competing interests exist. EDAT- 2026/08/25 17:35 MHDA- 2026/08/25 17:36 PMCR- 2026/08/25 CRDT- 2026/08/25 13:34 PHST- 2026/04/07 00:00 [received] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/08/25 17:36 [medline] PHST- 2026/08/25 17:35 [pubmed] PHST- 2026/08/25 13:34 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - PONE-D-26-16139 [pii] AID - 10.1371/journal.pone.0356461 [doi] PST - epublish SO - PLoS One. 2026 Aug 25;21(8):e0356461. doi: 10.1371/journal.pone.0356461. eCollection 2026. PMID- 42640905 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260827 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 8 DP - 2026 TI - Identification and risk-factor analysis for individuals at high risk for keratoconus via machine learning and logistic regression. PG - e0354924 LID - 10.1371/journal.pone.0354924 [doi] LID - e0354924 AB - PURPOSE: To evaluate keratoconus (KC) risk factors and to develop a machine-learning (ML) model for KC and myopia classification. METHODS: In this retrospective single-center cross-sectional study, demographic and lifestyle data from patients with KC and individuals from a preoperative refractive surgery clinic were collected from January 20, 2024, to December 1, 2024. Univariable and multivariable regression analyses were used to identify key risk factors. Additionally, random forest (RF)-recursive feature elimination (RFE), extreme gradient boosting (XGBoost)-RFE, and univariable logistic regression were applied to select factors for ML models. Seven ML models were developed for a lifestyle-based classification system, with the performance being validated through discrimination and calibration, and interpretability being improved using SHapley Additive exPlanations (SHAP). RESULTS: Analysis of 711 patients (mean [standard deviation] age, 26.6 [7.1] years; 439 males [61.7%]) revealed 275 with KC. Multivariable regression analysis identified seven risk factors for KC, including male sex, higher body-mass index (BMI), lower education level, more distant childhood residence, allergic conjunctivitis, and increased eye-rubbing intensity and frequency. After feature selection of 24 variables, the neural-network model demonstrated the highest performance (area under the receiver operating characteristic curve [AUROC] = 0.79), followed by RF (AUROC = 0.77) and XGBoost (AUROC = 0.76). SHAP analysis consistently highlighted eye-rubbing intensity, sex, BMI, and childhood residence among the top 10 factors across the top three models, which were also confirmed by univariable logistic regression. CONCLUSION: ML models can distinguish high-risk KC groups based on clinical risk factors, facilitating risk stratification and early lifestyle interventions. CI - Copyright: (c) 2026 Du et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Du, Kaiyue AU - Du K AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Peng, Rongmei AU - Peng R AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Chen, Yueguo AU - Chen Y AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Yuan, Bowei AU - Yuan B AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Chen, Wei AU - Chen W AD - Institute of Automation, Chinese Academy of Sciences, Beijing, China. FAU - Han, Liang AU - Han L AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Xiao, Gege AU - Xiao G AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Qu, Yi AU - Qu Y AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. FAU - Hong, Jing AU - Hong J AUID- ORCID: 0000-0002-8079-2073 AD - Department of Ophthalmology, Peking University Third Hospital, Beijing, China. AD - Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China. LA - eng PT - Journal Article DEP - 20260825 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Keratoconus/epidemiology/etiology/diagnosis MH - Female MH - Risk Factors MH - Male MH - *Machine Learning MH - Logistic Models MH - Retrospective Studies MH - Adult MH - Cross-Sectional Studies MH - Random Forest MH - Boosting Machine Learning Algorithms MH - Predictive Learning Models MH - Classification Algorithms MH - Young Adult PMC - PMC13505905 COIS- The authors have declared that no competing interests exist. EDAT- 2026/08/25 17:35 MHDA- 2026/08/25 17:36 PMCR- 2026/08/25 CRDT- 2026/08/25 13:34 PHST- 2025/06/03 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/08/25 17:36 [medline] PHST- 2026/08/25 17:35 [pubmed] PHST- 2026/08/25 13:34 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - PONE-D-25-28249 [pii] AID - 10.1371/journal.pone.0354924 [doi] PST - epublish SO - PLoS One. 2026 Aug 25;21(8):e0354924. doi: 10.1371/journal.pone.0354924. eCollection 2026. PMID- 42640180 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260903 IS - 1469-0705 (Electronic) IS - 0960-7692 (Print) IS - 0960-7692 (Linking) VI - 68 IP - 3 DP - 2026 Sep TI - Modified umbilical artery Doppler scoring system based on multisite assessment: association with perinatal outcome in early and late fetal growth restriction. PG - 341-350 LID - 10.1002/uog.70319 [doi] AB - OBJECTIVES: To evaluate a novel bilateral, segment-based umbilical artery (UA) Doppler scoring system in pregnancies complicated by early- or late-onset fetal growth restriction (FGR) and to investigate its association with adverse perinatal outcome. METHODS: This single-center prospective cohort study, conducted between May 2025 and December 2025, included singleton pregnancies diagnosed with FGR according to Delphi consensus criteria. Bilateral UA Doppler measurements were obtained from six predefined anatomical sites: the perivesical segment, the free-loop segment and the placental insertion site in each UA. End-diastolic flow at each site was categorized as present, absent or reversed and incorporated into a cumulative UA Doppler score (0-18 points). Composite adverse perinatal outcome (CAPO) was defined as the occurrence of at least one of the following: neonatal hypoglycemia, need for phototherapy, neonatal sepsis, respiratory distress syndrome, need for continuous positive airway pressure, need for mechanical ventilation, 5-min Apgar score < 7 or admission to the neonatal intensive care unit (NICU). Participants were stratified by UA Doppler score (< 3 vs >/= 3 points). Multivariable logistic regression analysis was used to assess the association between UA Doppler score as a continuous or dichotomized variable and CAPO, adjusting for maternal age, body mass index, parity, mode of conception, estimated fetal weight percentile and gestational age at delivery. In addition, the prevalence of individual markers of fetoplacental hemodynamic deterioration, including abnormal ductus venosus Doppler, cerebroplacental ratio < 5(th) percentile, intrauterine fetal demise, fetal distress leading to delivery and 5-min Apgar score < 7, was analyzed across UA Doppler score categories (0-2, 3-5, 6-8, 9-12 and > 12 points). RESULTS: A total of 251 pregnancies with FGR were included, of which 117 were early onset (< 32 weeks' gestation) and 134 were late onset (>/= 32 weeks' gestation). Higher UA Doppler scores (>/= 3 points) were associated significantly with preterm delivery and higher rates of NICU admission and CAPO in both early- and late-onset FGR. In early-onset FGR, higher scores were associated additionally with lower birth weight. The UA Doppler score remained associated independently with CAPO on multivariable logistic regression analysis. A significant linear trend was observed across increasing UA Doppler score categories for the rate of CAPO and individual markers of fetoplacental hemodynamic deterioration. CONCLUSIONS: In pregnancies complicated by early-onset or late-onset FGR, a higher UA Doppler score based on a multisite bilateral scoring system is associated independently with adverse perinatal outcome. These findings support the feasibility of a segment-based approach to UA Doppler assessment. Further studies are required to determine the clinical benefit and feasibility of adoption within current surveillance strategies. (c) 2026 International Society of Ultrasound in Obstetrics and Gynecology. CI - (c) 2026 International Society of Ultrasound in Obstetrics and Gynecology. FAU - Bulan, D D AU - Bulan DD AUID- ORCID: 0000-0001-9983-2306 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Bayraktar, B AU - Bayraktar B AUID- ORCID: 0000-0001-6233-4207 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. AD - Department of Obstetrics and Gynecology, Division of Perinatology, Turgut Ozal University Malatya Training and Research Hospital, Malatya, Turkey. FAU - Dayanan, R AU - Dayanan R AUID- ORCID: 0000-0002-8192-8841 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Ozkan, M A AU - Ozkan MA AUID- ORCID: 0000-0002-2437-9719 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Tonyali, N V AU - Tonyali NV AUID- ORCID: 0000-0002-7284-6887 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Seyhanli, Z AU - Seyhanli Z AUID- ORCID: 0000-0003-3924-3723 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Yilmaz, Z V AU - Yilmaz ZV AUID- ORCID: 0000-0002-8719-1879 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260825 PL - England TA - Ultrasound Obstet Gynecol JT - Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology JID - 9108340 SB - IM MH - Humans MH - *Fetal Growth Retardation/diagnostic imaging MH - *Umbilical Arteries/diagnostic imaging MH - Pregnancy MH - Female MH - Prospective Studies MH - *Ultrasonography, Doppler/methods MH - *Ultrasonography, Prenatal/methods MH - Adult MH - Infant, Newborn MH - Pregnancy Outcome MH - Gestational Age PMC - PMC13532136 OTO - NOTNLM OT - Doppler scoring system OT - adverse perinatal outcome OT - fetal growth restriction OT - perinatal outcome OT - umbilical artery Doppler EDAT- 2026/08/25 11:38 MHDA- 2026/09/01 11:39 PMCR- 2026/09/01 CRDT- 2026/08/25 09:53 PHST- 2026/03/28 00:00 [revised] PHST- 2025/12/15 00:00 [received] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/09/01 11:39 [medline] PHST- 2026/08/25 11:38 [pubmed] PHST- 2026/08/25 09:53 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - UOG70319 [pii] AID - 10.1002/uog.70319 [doi] PST - ppublish SO - Ultrasound Obstet Gynecol. 2026 Sep;68(3):341-350. doi: 10.1002/uog.70319. Epub 2026 Aug 25. PMID- 42639351 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260826 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Prediction of gait subtypes in children with bilateral spastic cerebral palsy using Edinburgh Visual Gait Score. PG - 1884116 LID - 10.3389/fpubh.2026.1884116 [doi] LID - 1884116 AB - OBJECTIVES: Early and accurate gait subtype classification in children with spastic bilateral cerebral palsy (CP) is essential for guiding rehabilitation. While three-dimensional gait analysis is limited by cost and accessibility, the Edinburgh Visual Gait Score (EVGS) provides a feasible observational tool. This study evaluates the discriminative value of EVGS-derived features using machine learning to support gait phenotype stratification. METHODS: This retrospective study included 40 children with spastic bilateral CP (80 lower limbs). EVGS item-level and subscale scores were extracted from standardized gait videos. Gait patterns were classified into four pathological subtypes by two blinded raters. A Random Forest (RF) classifier was evaluated using 5-fold stratified group cross-validation, with Multinomial Logistic Regression (MLR) serving as a benchmark. To address within-subject dependency, a sensitivity analysis involving random single-limb sampling was performed. Model performance was assessed using balanced accuracy, macro-averaged F1-score, area under the curve (AUC), and class-specific sensitivity, specificity, precision, recall, and F1-score. Feature importance was analyzed by permutation and Gini metrics. RESULTS: The RF model using item-level features outperformed MLR, achieving a mean balanced accuracy of 0.64 (SD = 0.03) and a macro-AUC of 0.74 (SD = 0.05). Item-level data consistently outperformed aggregated subscale scores. Sensitivity analysis using random single-limb sampling confirmed the robustness of these findings, yielding comparable performance estimates. For class-specific performance, the model achieved moderate discriminative ability for Type 1 (AUC = 0.76) and Type 3 (AUC = 0.69), limited performance for Type 2 (AUC = 0.55) due to feature overlap, and high discriminative ability for Type 4 (AUC = 0.89). Feature importance analysis identified hip peak flexion at swing (Item 13), knee position at terminal swing (Item 10), knee peak extension at stance (Item 9), trunk peak sagittal position (Item 16), and maximum ankle dorsiflexion at swing (Item 7) as key predictors. CONCLUSION: EVGS item-level features facilitate moderate yet robust gait subtype classification in spastic bilateral CP. The integration of EVGS with machine learning presents a promising adjunctive approach for preliminary assessment, particularly in resource-limited settings; however, external validation is requisite prior to clinical implementation. CI - Copyright (c) 2026 Tong, Chen, Xu, Gao, Bai, Liu, Zhang, Yun and Huang. FAU - Tong, Nan AU - Tong N AD - Department of Rehabilitation Medicine, Shenzhen Children's Hospital, Shenzhen, China. FAU - Chen, Turong AU - Chen T AD - Department of Rehabilitation Medicine, Shenzhen Children's Hospital, Shenzhen, China. FAU - Xu, Long AU - Xu L AD - Department of Pediatric Rehabilitation, Xiangya Boai Rehabilitation Hospital, Changsha, China. FAU - Gao, Li AU - Gao L AD - Department of Rehabilitation Medicine, Shenzhen Children's Hospital, Shenzhen, China. FAU - Bai, Xue AU - Bai X AD - Department of Rehabilitation Medicine, Shenzhen Children's Hospital, Shenzhen, China. FAU - Liu, Guixiang AU - Liu G AD - Department of Rehabilitation Medicine, Shenzhen Children's Hospital, Shenzhen, China. FAU - Zhang, Dongxue AU - Zhang D AD - Department of Rehabilitation Medicine, Shenzhen Children's Hospital, Shenzhen, China. FAU - Yun, Guojun AU - Yun G AD - Department of Rehabilitation Medicine, Shenzhen Children's Hospital, Shenzhen, China. FAU - Huang, Meihuan AU - Huang M AD - Department of Rehabilitation Medicine, Shenzhen Children's Hospital, Shenzhen, China. AD - Department of Rehabilitation Sciences, Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Kowloon, Hong Kong SAR, China. LA - eng PT - Journal Article DEP - 20260810 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology/classification/complications MH - Retrospective Studies MH - Female MH - Male MH - Child MH - *Gait/physiology MH - Machine Learning MH - *Gait Analysis/methods MH - Random Forest MH - Child, Preschool MH - Classification Algorithms PMC - PMC13501382 OTO - NOTNLM OT - Edinburgh Visual Gait Score OT - Random Forest OT - gait classification OT - machine learning OT - observational gait analysis OT - pediatric rehabilitation OT - spastic bilateral cerebral palsy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/25 11:38 MHDA- 2026/08/25 11:39 PMCR- 2026/08/10 CRDT- 2026/08/25 06:29 PHST- 2026/05/18 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/25 11:39 [medline] PHST- 2026/08/25 11:38 [pubmed] PHST- 2026/08/25 06:29 [entrez] PHST- 2026/08/10 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1884116 [doi] PST - epublish SO - Front Public Health. 2026 Aug 10;14:1884116. doi: 10.3389/fpubh.2026.1884116. eCollection 2026. PMID- 42639017 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260825 LR - 20260826 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 17 DP - 2026 TI - Composite fiber remodels gut microbiota and shows a trend of alleviating dyspepsia in adolescents with functional dyspepsia: a 16S rRNA pilot study. PG - 1844725 LID - 10.3389/fmicb.2026.1844725 [doi] LID - 1844725 AB - BACKGROUND: Adolescent functional dyspepsia (FD) is highly prevalent and closely linked to intestinal microbiota imbalance. Dietary fiber exerts prebiotic effects by regulating gut microbiota, but targeted studies investigating whether composite fiber can modulate gut microbiota and alleviate dyspeptic symptoms in adolescent FD patients remain scarce. This pilot trial aimed to explore the gut microbial regulatory characteristics and symptomatic improvement trend of standardized composite fiber supplementation. METHODS: Thirty-two adolescents with FD were enrolled in a 28-day double-blind, placebo-controlled pilot trial (treatment group: n = 15, 15 g/d composite fiber; control group: n = 17, isoenergetic maltodextrin). Fecal samples were collected post-intervention for 16S rRNA V3-V4 region sequencing. Microbial functional potential was predicted via PICRUSt1, and Fisher's exact conditional MLE was adopted to compare the binary symptom improvement rates. RESULTS: Composite fiber elevated all alpha-diversity indices (FDR < 0.05) and separated gut communities (weighted UniFrac PERMANOVA: F = 68.3, R(2) = 0.237, p = 0.018), independent of demographics. The intervention was associated with an increased abundance of Akkermansia, Romboutsia, and [Eubacterium]_coprostanoligenes_group, while being associated with a reduction in [Ruminococcus]_gnavus_group and Veillonella. Notably, cross-sectional FD case-control studies reported contradictory shifts of these genera, and microbial responses to intervention show prominent context-dependent heterogeneity across published research. PICRUSt1-based functional prediction suggested significant upregulation of steroid and flavonoid biosynthesis pathways in the treatment group. The symptom improvement rate was numerically higher in the treatment group (66.7% vs. 47.1%), although this difference was not statistically significant (p = 0.3075, OR = 2.19, 95% CI: 0.44-12.15). CONCLUSION: Composite fiber intervention reshapes gut microbial diversity, community structure and predicted metabolic functional profiles in adolescents with FD, alongside a non-significant numerical trend toward the alleviation of dyspeptic discomfort. Owing to substantial inter-study heterogeneity and context-dependent microbial responses, the observed genus-level alterations cannot be unequivocally characterized as uniformly beneficial outcomes, nor can direct causal relationships between single microbial taxa and clinical symptom improvement be inferred, as formal mediation analyses were not performed. This pilot study provides preliminary microbiological evidence for a fiber-based non-pharmacological intervention. Large multi-center trials combining multi-omics datasets and formal mediation analysis are required to validate clinical efficacy and untangle complex microbiota-symptom associations. CI - Copyright (c) 2026 Yu, Lv, Yang, Zhang, Yang, Wei, Zhang and Li. FAU - Yu, Chengrui AU - Yu C AD - Shihezi University School of Public Health, Shihezi, China. FAU - Lv, Jingsen AU - Lv J AD - Forevergen Biosciences Co, Ltd., Guangzhou, China. FAU - Yang, Jianli AU - Yang J AD - Department of Radiology, Changji Branch of the First Affiliated Hospital of Xinjiang Medical University, Changji, Xinjiang, China. FAU - Zhang, Yanping AU - Zhang Y AD - Department of Clinical Laboratory, Changji Branch of the First Affiliated Hospital of Xinjiang Medical University, Changji, Xinjiang, China. FAU - Yang, Ting AU - Yang T AD - Department of Pathology, Changji Branch of the First Affiliated Hospital of Xinjiang Medical University, Changji, Xinjiang, China. FAU - Wei, Yuan AU - Wei Y AD - Department of Oncology, Changji Branch of the First Affiliated Hospital of Xinjiang Medical University, Changji, Xinjiang, China. FAU - Zhang, Yuan AU - Zhang Y AD - Department of Colorectal Surgery, Changji Branch of the First Affiliated Hospital of Xinjiang Medical University, Changji, Xinjiang, China. FAU - Li, Jiaying AU - Li J AD - Department of Teaching Research, Changji Branch of the First Affiliated Hospital of Xinjiang Medical University, Changji, Xinjiang, China. AD - School of Food Science and Technology, Shihezi University, Shihezi, Xinjiang, China. LA - eng PT - Journal Article DEP - 20260810 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC13500627 OTO - NOTNLM OT - 16S rRNA sequencing OT - adolescents OT - composite dietary fiber OT - functional dyspepsia OT - gut microbiota COIS- JLv was employed by the Forevergen Biosciences Co, Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/25 11:38 MHDA- 2026/08/25 11:39 PMCR- 2026/08/10 CRDT- 2026/08/25 05:58 PHST- 2026/04/01 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/25 11:39 [medline] PHST- 2026/08/25 11:38 [pubmed] PHST- 2026/08/25 05:58 [entrez] PHST- 2026/08/10 00:00 [pmc-release] AID - 10.3389/fmicb.2026.1844725 [doi] PST - epublish SO - Front Microbiol. 2026 Aug 10;17:1844725. doi: 10.3389/fmicb.2026.1844725. eCollection 2026. PMID- 42639006 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260826 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Pediatric hyperuricemia: genetic basis, metabolic mechanisms, and clinical implications. PG - 1841803 LID - 10.3389/fendo.2026.1841803 [doi] LID - 1841803 AB - Hyperuricemia (HUA) is a heterogeneous group of metabolic disorders caused by long-term disturbances in purine metabolism. In recent years, although adult HUA and gout have been extensively studied, the understanding of HUA and gout in children and adolescents remains insufficient. Diagnostic criteria for adult HUA are well-established, but no consensus has yet been reached regarding its definition in children and adolescents. This review summarizes the current understanding of pediatric HUA, emphasizing its genetic basis, metabolic mechanisms, and clinical associations. ATP-binding cassette subfamily G member 2 (ABCG2) dysfunction, gene-defined forms of autosomal dominant tubulointerstitial kidney disease (ADTKD), particularly ADTKD-UMOD and ADTKD-REN, and selected purine metabolism disorders contribute to early-onset HUA, gout, nephrolithiasis, and renal involvement. Obesity-related insulin resistance (IR) may promote urate accumulation through pathways linked to oxidative stress, endothelial dysfunction, and inflammasome activation. Persistent elevation of uric acid (UA) has been associated with chronic kidney disease (CKD) progression, elevated blood pressure (BP), and subclinical cardiovascular remodeling. However, many of these mechanistic associations are supported primarily by adult and experimental studies and require further validation in children. We also review non-pharmacological management and indication-based pharmacological treatment strategies for pediatric HUA. These indications include asymptomatic hyperuricemia (AH), pediatric gout, UA nephrolithiasis, inherited purine metabolism disorders, CKD-associated HUA, and tumor lysis syndrome (TLS)-associated acute HUA, with emphasis on pediatric evidence, regulatory approval, off-label use, dosing, monitoring, and safety. In children, asymptomatic serum urate elevation is often the first recognized presentation, whereas nephrolithiasis, gout, renal dysfunction, or acute HUA should prompt evaluation for genetic, metabolic, renal, or treatment-related causes. These findings underscore the need for early identification and personalized intervention in children with HUA to prevent long-term renal and metabolic complications. CI - Copyright (c) 2026 Zhou, Lv, Hong, Liu, Jin, Zhang and Liu. FAU - Zhou, Jing AU - Zhou J AD - Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, China. AD - First Clinical Medical College, Shanxi Medical University, Taiyuan, China. FAU - Lv, Jianing AU - Lv J AD - Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, China. AD - First Clinical Medical College, Shanxi Medical University, Taiyuan, China. FAU - Hong, Chunhuan AU - Hong C AD - Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, China. AD - First Clinical Medical College, Shanxi Medical University, Taiyuan, China. FAU - Liu, Qinhao AU - Liu Q AD - Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, China. AD - First Clinical Medical College, Shanxi Medical University, Taiyuan, China. FAU - Jin, Shuqing AU - Jin S AD - Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, China. AD - First Clinical Medical College, Shanxi Medical University, Taiyuan, China. FAU - Zhang, Yi AU - Zhang Y AD - Department of Pharmacology, Shanxi Medical University, Taiyuan, China. AD - Medicinal Basic Research Innovation Center of Chronic Kidney Disease, Ministry of Education, Shanxi Medical University, Taiyuan, China. FAU - Liu, Yunfeng AU - Liu Y AD - Department of Endocrinology, First Hospital of Shanxi Medical University, Taiyuan, China. AD - First Clinical Medical College, Shanxi Medical University, Taiyuan, China. LA - eng PT - Journal Article PT - Review DEP - 20260810 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 268B43MJ25 (Uric Acid) SB - IM MH - Humans MH - *Hyperuricemia/genetics/metabolism MH - Child MH - Uric Acid/metabolism MH - Adolescent PMC - PMC13501462 OTO - NOTNLM OT - children and adolescents OT - chronic kidney disease OT - obesity OT - pediatric hyperuricemia OT - urate-lowering therapy OT - uric acid COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/25 11:38 MHDA- 2026/08/25 11:39 PMCR- 2026/08/10 CRDT- 2026/08/25 05:56 PHST- 2026/03/29 00:00 [received] PHST- 2026/07/19 00:00 [revised] PHST- 2026/07/28 00:00 [accepted] PHST- 2026/08/25 11:39 [medline] PHST- 2026/08/25 11:38 [pubmed] PHST- 2026/08/25 05:56 [entrez] PHST- 2026/08/10 00:00 [pmc-release] AID - 10.3389/fendo.2026.1841803 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Aug 10;17:1841803. doi: 10.3389/fendo.2026.1841803. eCollection 2026. PMID- 42638524 OWN - NLM STAT- Publisher LR - 20261006 IS - 1537-6591 (Electronic) IS - 1058-4838 (Linking) DP - 2026 Aug 25 TI - When Choosing Antiretroviral Therapy Meets Immigration Policy: An Ethical Analysis. LID - ciag442 [pii] LID - 10.1093/cid/ciag442 [doi] AB - Migration policies increasingly shape the conditions of care for migrants living with HIV. In France, access to residence permits on medical grounds intersects with clinical practice, raising important ethical challenges. We describe a 29-year-old woman from Guinea living in France with HIV and severe obesity, with an irregular migration status. Although virologically stable on oral antiretroviral therapy, she requests a switch to a long-acting injectable regimen, motivated by both anticipated administrative implications and the desire for greater discretion. Through this case, we examine how therapeutic reasoning in HIV care may be shaped by legal and social determinants. Using the principlism framework of Beauchamp and Childress, complemented by Tronto's ethics of care, we highlight tensions related to justice, beneficence, non-maleficence, and autonomy. Uncertainty surrounding administrative decision-making may lead patients and clinicians to perceive treatment choices as influencing legal outcomes. Differences between oral and injectable regimens raise issues of equity, feasibility, and social impact. Risks related to treatment interruption, particularly in contexts of legal instability, further complicate clinical reasoning. This case underscores the need to integrate legal and social determinants into therapeutic reasoning and supports the development of guidance from professional societies to assist clinicians facing these complex decisions. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Diarra, Ava AU - Diarra A AUID- ORCID: 0000-0001-5468-0695 AD - Department of Infectious Diseases and Tropical Medicine, AP-HP, Hopitaux Universitaires Paris Seine-Saint-Denis, Hopital Avicenne and Hopital Jean Verdier, Bobigny, France. FAU - Vignier, Nicolas AU - Vignier N AD - Department of Infectious Diseases and Tropical Medicine, AP-HP, Hopitaux Universitaires Paris Seine-Saint-Denis, Hopital Avicenne and Hopital Jean Verdier, Bobigny, France. AD - Universite Sorbonne Paris Nord and Universite Paris Cite, Inserm, UFR SMBH, IAME, UMR 1137, Paris, France. FAU - Tantet, Claire AU - Tantet C AD - Department of Infectious Diseases and Tropical Medicine, AP-HP, Hopitaux Universitaires Paris Seine-Saint-Denis, Hopital Avicenne and Hopital Jean Verdier, Bobigny, France. FAU - Petit, Bettina AU - Petit B AD - Department of Infectious Diseases and Tropical Medicine, AP-HP, Hopitaux Universitaires Paris Seine-Saint-Denis, Hopital Avicenne and Hopital Jean Verdier, Bobigny, France. FAU - Delagreverie, Heloise AU - Delagreverie H AD - Department of Virology, AP-HP, Hopitaux Universitaires Paris Seine-Saint-Denis, Hopital Avicenne and Hopital Jean Verdier, Bobigny, France. FAU - Milleliri, Ornella AU - Milleliri O AD - Department of Infectious Diseases and Tropical Medicine, AP-HP, Hopitaux Universitaires Paris Seine-Saint-Denis, Hopital Avicenne and Hopital Jean Verdier, Bobigny, France. FAU - Bouchaud, Olivier AU - Bouchaud O AD - Department of Infectious Diseases and Tropical Medicine, AP-HP, Hopitaux Universitaires Paris Seine-Saint-Denis, Hopital Avicenne and Hopital Jean Verdier, Bobigny, France. AD - Universite Sorbonne Paris Nord and Universite Paris Cite, IRD, Inserm, CEPED, UMR 196, Bobigny, France. FAU - Goupil de Bouille, Jeanne AU - Goupil de Bouille J AUID- ORCID: 0000-0002-3013-9850 AD - Department of Infectious Diseases and Tropical Medicine, AP-HP, Hopitaux Universitaires Paris Seine-Saint-Denis, Hopital Avicenne and Hopital Jean Verdier, Bobigny, France. AD - Laboratoire Educations et Promotion de la Sante,Universite Sorbonne Paris Nord, LEPS, Bobigny, France. LA - eng PT - Journal Article DEP - 20260825 PL - United States TA - Clin Infect Dis JT - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JID - 9203213 SB - IM OTO - NOTNLM OT - HIV OT - anti retroviral therapy OT - migrant COIS- Potential conflicts of interest. A. D. received a grant from IDSA and payment honoraria from Shionogi. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. EDAT- 2026/08/25 05:34 MHDA- 2026/08/25 05:34 CRDT- 2026/08/25 04:03 PHST- 2026/02/05 00:00 [received] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/08/25 05:34 [medline] PHST- 2026/08/25 05:34 [pubmed] PHST- 2026/08/25 04:03 [entrez] AID - 8769915 [pii] AID - 10.1093/cid/ciag442 [doi] PST - aheadofprint SO - Clin Infect Dis. 2026 Aug 25:ciag442. doi: 10.1093/cid/ciag442. PMID- 42635550 OWN - NLM STAT- MEDLINE DCOM- 20260824 LR - 20260827 IS - 2047-3095 (Electronic) IS - 2047-3087 (Print) IS - 2047-3087 (Linking) VI - 37 IP - 2 DP - 2026 Apr TI - Clinical validation of the nursing diagnosis of inadequate nutritional intake in children with cancer. PG - 274-282 LID - 10.1177/20473087261450939 [doi] AB - PurposeTo clinically validate the nursing diagnosis "Inadequate Nutritional Intake" based on elements identified within a specific situation theory framework in the context of children with cancer.MethodThis is a diagnostic accuracy study following the Standards for Reporting Diagnostic Accuracy Studies (STARD) protocol. Specifically, it refers to the clinical validation phase of the nursing diagnosis Inadequate nutritional intake, using a cross-sectional design. The study was conducted in a tertiary pediatric hospital with a sample of 69 children diagnosed with cancer.FindingsA total of 11 clinical indicators demonstrated diagnostic accuracy above 50%, including: ascites, low weight-for-age 77% sensitivity, 97% specificity, and 88% precision, outperforming the static method. This explainable data-driven framework improves data quality, transparency, and reproducibility, supporting scalable epidemiologic analyses using AI-ready dietary data. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. FAU - Massara, Paraskevi AU - Massara P AUID- ORCID: 0000-0003-0906-0985 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada. FAU - Saab, Stephanie AU - Saab S AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. FAU - Asrar, Arooj AU - Asrar A AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. FAU - Omand, Jessica AU - Omand J AUID- ORCID: 0000-0003-2095-3629 AD - School of Nutrition, Toronto Metropolitan University, Toronto, ON, Canada. FAU - Anderson, Laura N AU - Anderson LN AUID- ORCID: 0000-0002-6106-5073 AD - Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada. FAU - Keown-Stoneman, Charles AU - Keown-Stoneman C AUID- ORCID: 0000-0001-8790-1589 AD - Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada. AD - Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. FAU - Maguire, Jonathon L AU - Maguire JL AUID- ORCID: 0000-0002-4083-8612 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. AD - Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Department of Pediatrics, St. Michael's Hospital, Toronto, ON, Canada. AD - Joannah and Brian Lawson Center for Child Nutrition, University of Toronto, Toronto, ON, Canada. FAU - Bandsma, Robert H J AU - Bandsma RHJ AUID- ORCID: 0000-0001-6358-4750 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Translational Medicine Program, Research Institute, Hospital for Sick Children, Toronto, ON, Canada. FAU - Birken, Catherine S AU - Birken CS AUID- ORCID: 0000-0003-0308-8645 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Child Health Evaluative Sciences, The Hospital for Sick Children, Toronto, ON, Canada. AD - Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. AD - Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. AD - Department of Pediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Department of Pediatrics, St. Michael's Hospital, Toronto, ON, Canada. AD - Joannah and Brian Lawson Center for Child Nutrition, University of Toronto, Toronto, ON, Canada. FAU - Comelli, Elena M AU - Comelli EM AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Joannah and Brian Lawson Center for Child Nutrition, University of Toronto, Toronto, ON, Canada. LA - eng PT - Journal Article DEP - 20260824 PL - United States TA - Am J Epidemiol JT - American journal of epidemiology JID - 7910653 SB - IM OTO - NOTNLM OT - 24-hour dietary recall OT - AI-ready diet data OT - child and adult nutrition OT - data-driven outlier detection OT - longitudinal diet data EDAT- 2026/08/24 11:37 MHDA- 2026/08/24 11:37 CRDT- 2026/08/24 06:33 PHST- 2026/04/29 00:00 [received] PHST- 2026/08/10 00:00 [revised] PHST- 2026/08/19 00:00 [accepted] PHST- 2026/08/24 11:37 [medline] PHST- 2026/08/24 11:37 [pubmed] PHST- 2026/08/24 06:33 [entrez] AID - 8769274 [pii] AID - 10.1093/aje/kwag204 [doi] PST - aheadofprint SO - Am J Epidemiol. 2026 Aug 24:kwag204. doi: 10.1093/aje/kwag204. PMID- 42634399 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261015 IS - 1440-1754 (Electronic) IS - 1034-4810 (Linking) VI - 62 IP - 10 DP - 2026 Oct TI - Early Mortality Risk Assessment in Preterm Neonates Using the Prognostic Nutritional Index. PG - 1995-2002 LID - 10.1111/jpc.70554 [doi] AB - BACKGROUND: Preterm neonates are at high risk of morbidity and mortality due to physiological immaturity and susceptibility to complications. The prognostic nutritional index (PNI), calculated from serum albumin and lymphocyte counts, is an inflammation-based biomarker widely used to predict prognosis in adult diseases. However, its role in neonatology remains unclear. OBJECTIVE: To evaluate the association between PNI and early mortality in preterm infants. METHODS: Preterm infants born at < 32 weeks of gestation and admitted to the neonatal intensive care unit were retrospectively analysed. Demographic, clinical and laboratory data were obtained from medical records. Infants who died within the first 7 days of life were defined as the mortality group and compared with survivors. PNI was calculated using lymphocyte and albumin levels measured within the first 24 h of life. Receiver operating characteristic (ROC) analysis was used to evaluate the predictive performance of PNI for early mortality, and multi-variable logistic regression analysis was performed to identify independent predictors. RESULTS: A total of 142 infants were included, of whom 17 (12%) died within the first 7 days. Gestational age, birth weight and Apgar scores were significantly lower in the mortality group, whereas maternal smoking was more frequent. PNI values were significantly lower in infants who died (p < 0.05). ROC analysis demonstrated an AUC of 0.703 for PNI in predicting early mortality with a cut-off value of 40 (sensitivity 77%, specificity 64%). Multi-variable logistic regression analysis identified low PNI (< 40) and gestational age as independent predictors of early mortality. CONCLUSION: PNI may serve as an adjunctive biomarker to complement established clinical predictors of early neonatal mortality in preterm infants. CI - (c) 2026 Paediatrics and Child Health Division (The Royal Australasian College of Physicians). FAU - Butun Turk, Seyma AU - Butun Turk S AUID- ORCID: 0000-0002-6304-4073 AD - Department of Neonatology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Akin, Mustafa Senol AU - Akin MS AUID- ORCID: 0000-0003-0055-8277 AD - Department of Neonatology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Sari, Fatma Nur AU - Sari FN AUID- ORCID: 0000-0003-4643-7622 AD - Department of Neonatology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Alyamac Dizdar, Evrim AU - Alyamac Dizdar E AUID- ORCID: 0000-0001-8956-0917 AD - Department of Neonatology, Ankara Bilkent City Hospital, University of Health Sciences, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260823 PL - Australia TA - J Paediatr Child Health JT - Journal of paediatrics and child health JID - 9005421 RN - 0 (Biomarkers) RN - 0 (Serum Albumin) SB - IM MH - Humans MH - Infant, Newborn MH - Female MH - Retrospective Studies MH - *Infant, Premature MH - *Nutrition Assessment MH - Male MH - Risk Assessment/methods MH - Prognosis MH - *Infant Mortality MH - ROC Curve MH - Intensive Care Units, Neonatal MH - Biomarkers/blood MH - Gestational Age MH - Serum Albumin/analysis MH - Predictive Value of Tests OTO - NOTNLM OT - early mortality OT - inflammation OT - neonatal OT - preterm infants OT - prognostic nutritional index EDAT- 2026/08/24 06:59 MHDA- 2026/08/24 05:34 CRDT- 2026/08/24 02:23 PHST- 2026/08/03 00:00 [revised] PHST- 2026/05/01 00:00 [received] PHST- 2026/08/17 00:00 [accepted] PHST- 2026/08/24 06:59 [pubmed] PHST- 2026/08/24 05:34 [medline] PHST- 2026/08/24 02:23 [entrez] AID - 10.1111/jpc.70554 [doi] PST - ppublish SO - J Paediatr Child Health. 2026 Oct;62(10):1995-2002. doi: 10.1111/jpc.70554. Epub 2026 Aug 23. PMID- 42633470 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260823 LR - 20260824 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 7 DP - 2026 Jul TI - The Impact of Antenatal Lactation Counseling on Breastfeeding Practices and Newborn Feeding Behavior Among Primipara Mothers Attending a Tertiary Care Hospital in Puducherry, India: A Randomized Controlled Trial. PG - e113233 LID - 10.7759/cureus.113233 [doi] LID - e113233 AB - Introduction Although human milk provides unparalleled immunobiological and nutritional advantages essential for optimal neonatal development, the establishment of successful lactogenesis and sustained breastfeeding remains a complex psychophysiological challenge, particularly for primiparous mothers. First-time parturients frequently encounter biomechanical difficulties, such as suboptimal infant positioning and latch, which are compounded by postnatal anxiety. These factors can disrupt oxytocin-mediated milk let-down and precipitate disorganized neurobehavioral feeding reflexes in the newborn. Traditional postnatal lactation support is often reactive, administered during a period of high maternal fatigue and physiological stress. Therefore, structured antenatal lactation counseling emerges as a critical, proactive intervention designed to enhance maternal self-efficacy, provide anticipatory guidance, and mitigate the early introduction of prelacteal feeds. This randomized controlled trial (RCT) aimed to empirically validate this paradigm shift within a localized, high-volume clinical setting. It sought to investigate the effectiveness of targeted antenatal lactation counseling on both maternal breastfeeding practices and newborn feeding behaviors among primiparous mothers attending a tertiary care hospital in Puducherry, ultimately seeking to optimize perinatal care protocols through rigorous, evidence-based intervention. Methods An RCT was conducted with 130 primiparous women aged 18 to 35 years who had completed 32 weeks of gestation and delivered at term. A group counseling technique was used for the intervention group, wherein groups of five mothers received 30-minute antenatal lactation counseling sessions during antenatal visits. The lactation counseling on breastfeeding was repeated three times at 32, 34, and 36 weeks of gestation, while the control group received only routine care. Breastfeeding practices and newborn feeding behavior were assessed using a structured breastfeeding practices checklist and the Infant Breastfeeding Assessment Tool (IBFAT) on the second postnatal day. Results Baseline variables did not differ significantly between the groups. The intervention group showed significantly better breastfeeding practices (t = 5.384, p = 0.000) and newborn feeding behavior (t = 3.22, p = 0.02). Breast engorgement was lower in the intervention group, though the difference was not statistically significant. Conclusions Based on our findings, proper lactation counseling provided to primiparous mothers at each contact point during antenatal visits improves breastfeeding practices and promotes optimal newborn feeding behavior. CI - Copyright (c) 2026, Behera et al. FAU - Behera, Barsharani AU - Behera B AD - Obstetrics and Gynaecological Nursing, College of Nursing, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND. AD - Obstetrics and Gynaecology, Kalinga Institute of Nursing Sciences, Kalinga Institute of Industrial Technology (Deemed to be University), Bhubaneswar, IND. FAU - K, Kanimozhi AU - K K AD - Obstetrics and Gynaecological Nursing, College of Nursing, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND. FAU - Bethou, Adhisivam AU - Bethou A AD - Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, IND. LA - eng PT - Journal Article DEP - 20260723 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13499584 OTO - NOTNLM OT - breastfeeding practices OT - feeding behaviour. OT - lactation counselling OT - newborn OT - s: antenatal COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee (IEC) for Nursing Courses (Human Studies), JIPMER issued approval JIP/CON/IEC/M.Sc./2022/OBG/1. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/08/23 05:41 MHDA- 2026/08/23 05:42 PMCR- 2026/07/23 CRDT- 2026/08/23 04:19 PHST- 2026/07/21 00:00 [accepted] PHST- 2026/08/23 05:42 [medline] PHST- 2026/08/23 05:41 [pubmed] PHST- 2026/08/23 04:19 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - 10.7759/cureus.113233 [doi] PST - epublish SO - Cureus. 2026 Jul 23;18(7):e113233. doi: 10.7759/cureus.113233. eCollection 2026 Jul. PMID- 42632822 OWN - NLM STAT- Publisher LR - 20260822 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Aug 22 TI - Association between triglyceride-glucose index and elevated blood pressure among U.S. adolescents aged 12-17. LID - 10.1038/s41390-026-05407-4 [doi] AB - BACKGROUND: The triglyceride-glucose (TyG) index is a known cardiovascular risk factor in adults, but its association with elevated blood pressure (EBP) in adolescents remains unclear. We hypothesized that the TyG index is associated with EBP among U.S. adolescents aged 12-17 years. METHODS: This cross-sectional analysis included 4409 adolescents from the National Health and Nutrition Examination Survey (NHANES) 1999-2018. We used weighted multivariate logistic regression, weighted subgroup analysis, threshold effect and smoothing curve fitting to examine the association between the TyG index and EBP. RESULTS: Among the participants, 661 (14.9%) had EBP. After full adjustment, each unit rise in TyG index significantly boosted EBP odds (OR = 4.45, 95% CI 1.34-14.78, P = 0.02). A nonlinear relationship was observed, with an exploratory inflection point of the TyG index at 7.98. In BMI-stratified analyses, the association remained significant only among adolescents with BMI < 25 kg/m(2) (OR 3.09; 95%CI: 1.55-6.18; P < 0.01). Subgroup analyses revealed no significant interactions (all P for interaction >0.05). CONCLUSIONS: TyG index was cross-sectionally associated with EBP in U.S. 12-17-year-olds, with an exploratory inflection point. This suggests a potential low-cost indicator for risk stratification of adolescents with higher odds of EBP, pending verification in longitudinal studies. IMPACT: The triglyceride-glucose (TyG) index is cross-sectionally associated with elevated blood pressure (EBP) in U.S. 12-17-year-old adolescents, with an exploratory inflection point of 7.98. This study explores a TyG index exploratory inflection point for adolescent EBP risk in a nationally representative sample. TyG index, a routine and low-cost biomarker, presents potential utility for early risk stratification of adolescent EBP, although further prospective validation is required. The non-linear TyG index-EBP association highlights the potential need for age-specific metabolic risk stratification in adolescents. CI - (c) 2026. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Tang, Jiazhong AU - Tang J AD - Department of Pediatric Cardiac Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Shi, Yuexin AU - Shi Y AD - Department of Jinglang International Medical Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Jiao, Xianting AU - Jiao X AD - Department of Pediatric Infectious, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Yang, Ling AU - Yang L AD - Department of Pediatric Cardiac Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Huang, Jihong AU - Huang J AD - Department of Pediatric Cardiac Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Wang, Huiying AU - Wang H AD - Department of Pediatric Cardiac Center, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. 18221403205@163.com. LA - eng PT - Journal Article DEP - 20260822 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Consent statement: NHANES was conducted with approval by the National Center for Health Statistics Ethics Review Board and obtained informed written consent from all the individuals involved in the study. EDAT- 2026/08/23 05:41 MHDA- 2026/08/23 05:41 CRDT- 2026/08/22 23:18 PHST- 2026/02/19 00:00 [received] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/07/07 00:00 [revised] PHST- 2026/08/23 05:41 [medline] PHST- 2026/08/23 05:41 [pubmed] PHST- 2026/08/22 23:18 [entrez] AID - 10.1038/s41390-026-05407-4 [pii] AID - 10.1038/s41390-026-05407-4 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Aug 22. doi: 10.1038/s41390-026-05407-4. PMID- 42632660 OWN - NLM STAT- MEDLINE DCOM- 20260822 LR - 20260822 IS - 1873-7145 (Electronic) IS - 0963-9969 (Linking) VI - 242 IP - Pt 2 DP - 2026 Oct 31 TI - Urinary multi-mycotoxin exposure in the Portuguese population and associated sociodemographic determinants. PG - 119820 LID - S0963-9969(26)01504-8 [pii] LID - 10.1016/j.foodres.2026.119820 [doi] AB - European human biomonitoring (HBM) studies have increasingly adopted multi-mycotoxin approaches to capture complex exposure scenarios encountered in real-life diets. This nation-wide study provides the characterization, for the first time, of the mycotoxin profile of 295 urine samples collected from the Portuguese population in the continent and islands (archipelagos of Madeira and Azores), using an optimized and validated LC-MS/MS method for the characterization of 39 mycotoxins/metabolites. Nearly all study participants (99.3%) were exposed to at least one mycotoxin, with around half (54.2%) being co-exposed to only 2 detectable mycotoxins. Free-deoxynivalenol (free-DON, 84.7%) and tenuazonic acid (TeA, 95.6%) were the most prevalent mycotoxins. Citrinin (CIT, 11.5%), alpha-zearalenone (alpha-ZEL, 10.5%) and ochratoxin A (OTA, 9.5%) showed detection rates near 10%. Median concentrations (P50) for the two predominant mycotoxins were 0.79 mug/L (0.72 mug/g creatinine) for free-DON and 2.45 mug/L (2.08 mug/g creatinine) for TeA, with maximum values of 11.77 mug/L (10.06 mug/g creatinine) and 90.91 mug/L (114.15 mug/g creatinine), respectively. Sociodemographic patterns showed lower exposure in the Centre region and higher free-DON exposure in southern Portugal and the archipelagos. TeA exposure differed significantly by region and was lowest in the Lisbon Metropolitan Area and Algarve compared to the Center reference region. Low educational levels and spring sampling correlated with higher exposure for both toxins, but only education levels showed statistical significance in the linear regression analyses. For both TeA and free-DON, no differences in exposure were observed by sex, occupational status, or degree of urbanization. Overall, these findings underscore the importance of continuous surveillance, particularly under the current climate change scenario, and highlight the relevance of integrating human biomonitoring into national food safety and public health strategies. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Maris, Elias AU - Maris E AD - Centre of Excellence in Mycotoxicology and Public Health, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium; Laboratory of Molecular Bacteriology, Department of Microbiology and Immunology, Rega Institute, KU Leuven, Leuven, Belgium; Laboratory of Bioinformatics and (Eco-)Systems Biology, VIB Center for Microbiology, VIB, Leuven, Belgium. Electronic address: Elias.Maris@UGent.be. FAU - Namorado, Sonia AU - Namorado S AD - Department of Epidemiology, National Institute of Health Doutor Ricardo Jorge, Lisbon, Portugal; NOVA National School of Public Health, Public Health Research Centre, Comprehensive Health Research Center, CHRC, REAL, CCAL, NOVA University Lisbon, Lisbon, Portugal. Electronic address: sonia.namorado@insa.min-saude.pt. FAU - Chen, An AU - Chen A AD - Centre of Excellence in Mycotoxicology and Public Health, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium. Electronic address: An.Chen@UGent.be. FAU - Pero-Gascon, Roger AU - Pero-Gascon R AD - Centre of Excellence in Mycotoxicology and Public Health, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium; Department of Chemical Engineering and Analytical Chemistry, Institute for Research on Nutrition and Food Safety (INSA-UB), University of Barcelona, Spain. Electronic address: Roger.PeroGascon@UGent.be. FAU - De Boevre, Marthe AU - De Boevre M AD - Centre of Excellence in Mycotoxicology and Public Health, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium. Electronic address: Marthe.DeBoevre@UGent.be. FAU - De Saeger, Sarah AU - De Saeger S AD - Centre of Excellence in Mycotoxicology and Public Health, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium; Department of Biotechnology and Food Technology, Faculty of Sciences, University of Johannesburg, South Africa. Electronic address: Sarah.DeSaeger@UGent.be. FAU - Silva, Maria Joao AU - Silva MJ AD - NOVA National School of Public Health, Public Health Research Centre, Comprehensive Health Research Center, CHRC, REAL, CCAL, NOVA University Lisbon, Lisbon, Portugal; Department of Human Genetics, National Institute of Health Doutor Ricardo Jorge, Lisbon, Portugal. Electronic address: m.joao.silva@insa.min-saude.pt. FAU - Alvito, Paula AU - Alvito P AD - Department of Food and Nutrition, National Institute of Health Doutor Ricardo Jorge, Lisbon, Portugal; Centre for Environmental and Marine Studies (CESAM), University of Aveiro, Aveiro, Portugal. Electronic address: paula.alvito@insa.min-saude.pt. LA - eng PT - Journal Article DEP - 20260623 PL - Canada TA - Food Res Int JT - Food research international (Ottawa, Ont.) JID - 9210143 RN - 0 (Mycotoxins) SB - IM MH - Humans MH - Portugal MH - Female MH - Male MH - *Mycotoxins/urine MH - Adult MH - Biological Monitoring/methods MH - Middle Aged MH - Sociodemographic Factors MH - Young Adult MH - Tandem Mass Spectrometry MH - Aged MH - Adolescent MH - Environmental Exposure OTO - NOTNLM OT - Chemical exposure OT - Co-exposure OT - Exposome OT - Free-deoxynivalenol OT - Human biomonitoring OT - Mycotoxins OT - Portugal OT - Sociodemographic characteristics OT - Tenuazonic acid OT - Urine COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/22 23:43 MHDA- 2026/08/22 23:44 CRDT- 2026/08/22 20:53 PHST- 2026/03/12 00:00 [received] PHST- 2026/06/04 00:00 [revised] PHST- 2026/06/20 00:00 [accepted] PHST- 2026/08/22 23:44 [medline] PHST- 2026/08/22 23:43 [pubmed] PHST- 2026/08/22 20:53 [entrez] AID - S0963-9969(26)01504-8 [pii] AID - 10.1016/j.foodres.2026.119820 [doi] PST - ppublish SO - Food Res Int. 2026 Oct 31;242(Pt 2):119820. doi: 10.1016/j.foodres.2026.119820. Epub 2026 Jun 23. PMID- 42631747 OWN - NLM STAT- MEDLINE DCOM- 20260822 LR - 20261008 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 9 DP - 2026 Aug 22 TI - Assessing the psychological effects of eosinophilic esophagitis: a study on anxiety, self-concept, and depression in pediatric patients. LID - 689 [pii] LID - 10.1007/s00431-026-07350-2 [doi] AB - Eosinophilic esophagitis (EoE) is a chronic inflammatory condition of the esophagus that may impose a substantial psychological burden on affected children. Its impact on self-concept, anxiety, and depression has not been well characterized. This study aimed to investigate levels of self-concept, anxiety, and depression in children with EoE and to evaluate the psychological burden associated with the disease. Sixty-two children aged 6-18 years, including 31 patients with EoE and 31 controls without EoE, participated in the study. In the EoE group, psychological assessment was performed after at least 1 year of clinical follow-up and treatment; none of the patients were evaluated at the time of initial diagnosis. Psychological functioning was assessed using the Piers-Harris Children's Self-Concept Scale, the Screen for Child Anxiety Related Emotional Disorders (SCARED), and the Children's Depression Inventory (CDI), all validated in Turkish. Clinical characteristics, including symptom profile, disease duration, and medication use, were also recorded. The Mann-Whitney U-test was used for between-group comparisons. Children with EoE had significantly lower self-concept (Piers-Harris) scores and higher anxiety (SCARED) and depression (CDI) scores than controls (p < 0.001, p = 0.004, and p = 0.003, respectively). No significant associations were observed between psychological scores and general disease characteristics, including disease duration, medication use, or the presence of atopic comorbidities. CONCLUSION: Children with EoE demonstrated higher anxiety and depression scores and lower self-concept scores than controls despite having been followed and treated for at least 1 year before psychological assessment. These findings suggest that children with EoE may experience an increased psychological burden and support consideration of psychological assessment as part of multidisciplinary care. WHAT IS KNOWN: * Eosinophilic esophagitis (EoE) is a chronic immune-mediated disease that can negatively affect quality of life through persistent symptoms, dietary restrictions, and repeated medical procedures. * Previous studies suggest that children with EoE may be at increased risk for anxiety and depression, but data remain limited, particularly in non-Western populations. WHAT IS NEW: * Turkish children with EoE showed significantly higher anxiety and depression scores and lower self-concept scores than healthy controls. * Feeding-related symptoms, particularly dysphagia and food impaction sensations, were associated with greater psychological distress, highlighting the need for routine psychological assessment in pediatric EoE care. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Ozkaya, Mehmet AU - Ozkaya M AUID- ORCID: 0000-0002-8101-9058 AD - Division of Pediatric Allergy, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kosk Mah. Prof. Dr. Turhan Feyzioglu Cad. No:42 38039. Melikgazi, Kayseri, Turkey. dr.mehmetozk@gmail.com. FAU - Ozdamar, Emre AU - Ozdamar E AUID- ORCID: 0009-0002-0674-517X AD - Division of Pediatric Allergy, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kosk Mah. Prof. Dr. Turhan Feyzioglu Cad. No:42 38039. Melikgazi, Kayseri, Turkey. FAU - Bayazit, Zehra AU - Bayazit Z AUID- ORCID: 0000-0002-5875-4599 AD - Division of Pediatric Allergy, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kosk Mah. Prof. Dr. Turhan Feyzioglu Cad. No:42 38039. Melikgazi, Kayseri, Turkey. FAU - Erdogan, Burcu Ozge AU - Erdogan BO AUID- ORCID: 0000-0001-6859-0201 AD - Division of Pediatric Allergy, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kosk Mah. Prof. Dr. Turhan Feyzioglu Cad. No:42 38039. Melikgazi, Kayseri, Turkey. FAU - Gul, Melike Kevser AU - Gul MK AUID- ORCID: 0000-0002-0907-4503 AD - Department of Child and Adolescent Psychiatry, Faculty of Medicine, Erciyes University, Kayseri, Turkey. FAU - Tahan, Fulya AU - Tahan F AUID- ORCID: 0000-0002-8849-3422 AD - Division of Pediatric Allergy, Department of Pediatrics, Faculty of Medicine, Erciyes University, Kosk Mah. Prof. Dr. Turhan Feyzioglu Cad. No:42 38039. Melikgazi, Kayseri, Turkey. LA - eng PT - Journal Article DEP - 20260822 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Child MH - Female MH - *Self Concept MH - Adolescent MH - Male MH - *Eosinophilic Esophagitis/psychology/complications MH - *Anxiety/etiology/diagnosis MH - *Depression/etiology/diagnosis MH - Case-Control Studies MH - Turkey MH - Psychiatric Status Rating Scales OTO - NOTNLM OT - Anxiety OT - Child OT - Depression OT - Eosinophilic esophagitis OT - Psychological well-being OT - Self-concept COIS- Declarations. Ethical approval and informed consent: The study was conducted in accordance with the principles of the Declaration of Helsinki and was approved by the Erciyes University Ethics Committee (Approval No. 2023/691). Consent to participate: All participants provided informed consent prior to their inclusion in the study. Parents or guardians provided written consent for their child's participation in this study. Consent for publication: Not applicable. Competing interests: The authors have no relevant financial or non-financial interests to disclose. EDAT- 2026/08/22 22:41 MHDA- 2026/08/22 22:42 CRDT- 2026/08/22 11:04 PHST- 2026/06/03 00:00 [received] PHST- 2026/08/14 00:00 [accepted] PHST- 2026/08/10 00:00 [revised] PHST- 2026/08/22 22:42 [medline] PHST- 2026/08/22 22:41 [pubmed] PHST- 2026/08/22 11:04 [entrez] AID - 10.1007/s00431-026-07350-2 [pii] AID - 10.1007/s00431-026-07350-2 [doi] PST - epublish SO - Eur J Pediatr. 2026 Aug 22;185(9):689. doi: 10.1007/s00431-026-07350-2. PMID- 42630056 OWN - NLM STAT- Publisher LR - 20260822 IS - 1708-8283 (Electronic) IS - 0883-0738 (Linking) DP - 2026 Aug 21 TI - The Effects of Aerobic Exercise on Pediatric Headache-Related Disability and Quality of Life: A Pilot Randomized Controlled Trial. PG - 8830738261476485 LID - 10.1177/08830738261476485 [doi] AB - This pilot randomized-controlled trial aimed to evaluate the impact of aerobic exercise on (1) headache-related disability, via the Pediatric Migraine Disability Assessment Scale, and (2) quality of life, via the Pediatric Quality of Life Inventory and KIDSCREEN-27. Participants (8-17 years of age) were randomized at an initial 1:1 ratio revised to 2:1 to a 4-week at-home program of daily aerobic exercise or stretching. Nineteen participants (89% female, mean age = 14.3 +/- 2.2 years) completed the study. There were clinically meaningful differences in headache-related disability in both groups from baseline to post-study (standardized mean change, Hedges' g, in aerobic exercise group: 0.53 [95% CI: -0.29, 1.35]; stretching group: 0.71 [95% CI: -0.27, 1.66]), but no differences in quality of life (P values ranging from 0.06 to 1.00 across all domains). When considered alongside the broader health benefits of exercise documented elsewhere, our findings represent a preliminary signal warranting further investigation of exercise training as a potential care pathway for pediatric headache. Given our limited sample size, these findings should be interpreted with caution, and alone are insufficient to inform clinical recommendations. This study was limited by poor enrollment over 5 years and higher rates of drop-out in the aerobic exercise group. Future studies should seek to define and overcome feasibility barriers associated with exercise-based interventions. FAU - Artna, Erin AU - Artna E AUID- ORCID: 0000-0001-6829-1797 AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada. RINGGOLD: 274065 AD - Temerty Faculty of Medicine, University of Toronto, Toronto, Canada. AD - Department of Psychiatry, Faculty of Medicine, University of British Columbia, Vancouver, Canada. FAU - Reddy, Deepti AU - Reddy D AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada. RINGGOLD: 274065 FAU - Chen, Kitty AU - Chen K AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada. RINGGOLD: 274065 FAU - Longmuir, Patricia E AU - Longmuir PE AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada. RINGGOLD: 274065 AD - Faculty of Medicine, University of Ottawa, Ottawa, Canada. AD - Faculty of Health Sciences, University of Ottawa, Ottawa, Canada. FAU - Pohl, Daniela AU - Pohl D AUID- ORCID: 0000-0002-2996-7210 AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada. RINGGOLD: 274065 AD - Faculty of Medicine, University of Ottawa, Ottawa, Canada. AD - Division of Neurology, Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Canada. LA - eng PT - Journal Article DEP - 20260821 PL - United States TA - J Child Neurol JT - Journal of child neurology JID - 8606714 SB - IM OTO - NOTNLM OT - disability OT - exercise OT - migraine OT - pediatric OT - quality of life EDAT- 2026/08/22 05:37 MHDA- 2026/08/22 05:37 CRDT- 2026/08/22 02:53 PHST- 2026/08/22 05:37 [medline] PHST- 2026/08/22 05:37 [pubmed] PHST- 2026/08/22 02:53 [entrez] AID - 10.1177/08830738261476485 [doi] PST - aheadofprint SO - J Child Neurol. 2026 Aug 21:8830738261476485. doi: 10.1177/08830738261476485. PMID- 42628320 OWN - NLM STAT- Publisher LR - 20260821 IS - 1532-2238 (Electronic) IS - 1096-6374 (Linking) VI - 85 DP - 2026 Aug 17 TI - Precision medicine in pediatric growth disorders: Integrating clinical phenotype, genetics, IGF-1 biology and artificial intelligence: A systematic scoping review of PubMed-indexed literature (2000-2026). PG - 101721 LID - S1096-6374(26)00043-2 [pii] LID - 10.1016/j.ghir.2026.101721 [doi] AB - BACKGROUND: ecombinant human growth hormone (rhGH) has been used for four decades under a largely population-based dosing paradigm, yet growth response varies substantially among children with apparently similar auxological phenotypes. Advances in genomics, GH-insulin-like growth factor-1 (IGF-1) axis biomarkers, mathematical and machine-learning (ML) prediction models, and digital health technologies now allow individualized characterization of growth disorders, forming the basis of an emerging precision-endocrinology paradigm. OBJECTIVES: (1) to synthesize evidence on monogenic and polygenic genetic determinants of pediatric growth faltering and/or short stature and their diagnostic yield; (2) to evaluate GH-IGF-1 axis biomarkers and pharmacogenetic markers, including the IGF-1/IGFBP-3 molar ratio as a likely better indicator of bioactive IGF-1 than IGF-1 alone, together with mathematical/ML prediction models, for individualizing rhGH therapy; and (3) to appraise artificial intelligence (AI) and digital-health tools, bone-age algorithms, facial-recognition phenotyping, adherence-prediction models, and smartphone growth-monitoring, as instruments for operationalizing precision endocrinology in children and adolescents with growth disorders. METHODS: This is a systematic review employing narrative synthesis (a systematic scoping review). Reporting explicitly followed the PRISMA Extension for Scoping Reviews (PRISMA-ScR) checklist rather than the PRISMA 2020 statement for systematic reviews and meta-analyses, because the heterogeneous outcome metrics across genetic, diagnostic-accuracy, prediction-model, and AI/digital-health studies preclude meta-analytic pooling of a single quantitative effect size; PRISMA-ScR is the methodologically appropriate reporting framework for a review mapping evidence across such conceptually distinct domains. PubMed/MEDLINE was searched for English-language, pediatric (0-18 years) studies published between 2000 and 2026. Two-stage screening (title/abstract, then full text) was performed. Quality was appraised using design-appropriate tools: an adapted Newcastle-Ottawa Scale for genetic-association studies, QUADAS-2 for diagnostic-accuracy biomarker studies, PROBAST/TRIPOD-informed criteria for prediction-model and ML studies, and reference-standard/external-validation criteria for AI-imaging studies. Sixty-two studies were retained for qualitative synthesis. RESULTS: Monogenic defects (SHOX, ACAN, NPR2) and exome-sequencing panels explain a meaningful minority (approximately one-quarter) of previously "idiopathic" short stature, while genome-wide association studies and polygenic scores capture a substantial share of the remaining heritable variance, with polygenic risk scores achieving areas under the receiver-operating-characteristic curve up to 0.84 for predicting adult short stature. The IGF-1/IGFBP-3 M ratio outperforms IGF-1 alone for diagnosing GH deficiency (sensitivity 87.5%, specificity 83.0%), reflecting the greater bioavailability of free, unbound IGF-1 relative to that carried in the ternary IGF-1/IGFBP-3/acid-labile-subunit complex. GH-receptor exon-3 (d3) pharmacogenetic variants and machine-learning models (random forest, transcriptomic classifiers) improve prediction of individual rhGH response beyond classical mathematical models. AI-based bone-age algorithms achieve near-radiologist accuracy with reduced inter-observer variability, computer-aided facial-phenotyping tools show comparable diagnostic accuracy for syndromic short-stature disorders such as Noonan and Turner syndrome, and connected-device/ML adherence-monitoring and smartphone growth-tracking tools objectively detect suboptimal adherence and growth faltering earlier than conventional clinic-based surveillance; network meta-analyses of once-weekly long-acting rhGH formulations further suggest that reduced injection burden can translate into modestly improved height outcomes relative to daily rhGH. These findings are synthesized into a Precision-Medicine Cascade, a practice-oriented framework showing how genotype, biomarker, and digital data streams can be layered onto routine auxological assessment to guide same-visit clinical decisions on diagnostic work-up, dosing, and monitoring frequency. CONCLUSION: Converging genetic, biomarker, computational, and digital-health evidence supports a feasible, evidence-grounded trajectory toward individualized therapy, including rhGH and emerging growth-plate-targeted agents, in pediatric growth disorders. The Precision-Medicine Cascade proposed here offers pediatric endocrinologists an immediately applicable framework for integrating these tools into everyday practice. However, current tools remain adjunctive rather than replacement for clinical judgment, and prospective, ethnically diverse validation of integrated precision-endocrinology pathways is required before routine adoption. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Soliman, Ashraf T AU - Soliman AT AD - Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar. Electronic address: atsoliman@yahoo.com. FAU - Alyafei, Fawzia AU - Alyafei F AD - Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar. FAU - Alaaraj, Nada AU - Alaaraj N AD - Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar. FAU - Hamed, Noor AU - Hamed N AD - Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar. FAU - Ahmed, Shayma AU - Ahmed S AD - Department of Pediatrics, Hamad Medical Corporation, Doha, Qatar. LA - eng PT - Journal Article PT - Review DEP - 20260817 PL - Scotland TA - Growth Horm IGF Res JT - Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society JID - 9814320 SB - IM OTO - NOTNLM OT - Artificial intelligence OT - Genomics OT - Growth hormone OT - IGF-1 OT - Short stature COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/21 23:37 MHDA- 2026/08/21 23:37 CRDT- 2026/08/21 18:05 PHST- 2026/07/07 00:00 [received] PHST- 2026/07/30 00:00 [revised] PHST- 2026/08/12 00:00 [accepted] PHST- 2026/08/21 23:37 [medline] PHST- 2026/08/21 23:37 [pubmed] PHST- 2026/08/21 18:05 [entrez] AID - S1096-6374(26)00043-2 [pii] AID - 10.1016/j.ghir.2026.101721 [doi] PST - aheadofprint SO - Growth Horm IGF Res. 2026 Aug 17;85:101721. doi: 10.1016/j.ghir.2026.101721. PMID- 42628000 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260914 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Aug 21 TI - Mental Health, Gender Dysphoria, and Quality of Life in Trans Individuals Following Top Surgery: Protocol for a Prospective Cohort Study. PG - e83928 LID - 10.2196/83928 [doi] LID - e83928 AB - BACKGROUND: Top surgery refers to various gender-affirming surgical procedures involving breast or chest tissue. Existing research suggests top surgery improves physical, psychological, and social well-being in transgender and gender-diverse individuals (herein "trans") who desire it. However, most studies have been retrospective, have not used validated outcome measures, and have excluded nonbinary individuals, limiting the robustness of the existing research. OBJECTIVE: This study aims to examine changes in mental health, gender dysphoria, risky behaviors, and quality of life of trans people (including nonbinary individuals) following top surgery. METHODS: Trans individuals aged 16 years and older undergoing top surgery will be recruited from a single surgeon's office in Perth, Western Australia, as part of a longitudinal, prospective cohort study. Questionnaires will be administered to participants at 3 time points: within 8 weeks prior to surgery, 6-8 weeks post surgery, and 1 year post surgery. These questionnaires will collect data on patient demographics, planning and expectations for surgery, support received during surgery access, satisfaction with care received from their surgeon, use of gender-affirming hormones, mental health (ie, anxiety, depression, self-harm and suicide, and mental health diagnoses), gender euphoria and dysphoria, exercise and diet, disordered eating, quality of life, substance use, social acceptance and discrimination, and reflections on the experience and outcomes of their surgery. Patient-reported outcomes will be measured using validated instruments and bespoke items developed through community consultation. Validated instruments include the GENDER-Q (health professional subscale); the Generalized Anxiety Disorder 7-item; the Patient Health Questionnaire-9; the Gender Euphoria Scale; an adapted version of the Olson-Kennedy Chest Dysphoria Scale; the International Physical Activity Questionnaire - Short Form; the Eating Disorder Examination Questionnaire - Short; the Assessment of Quality of Life 8 Dimensions; and the Alcohol, Smoking, and Substance Involvement Screening Test - Short Form. Surgical satisfaction will be assessed using both patient- and surgeon-reported measures, enabling between-group comparisons. Quantitative data will be analyzed using linear regression models and repeated-measures ANOVA to compare outcomes across the 3 time points; qualitative data will undergo a general inductive approach to analysis to produce categories that contextualize and supplement the quantitative findings, as well as identify any novel or unexpected experiences. RESULTS: This study received funding in February 2024. Data collection commenced in May 2025 and is expected to be completed by December 2027. As of February 2026, 26 people have consented to participate. CONCLUSIONS: This study will extend research on the mental health, gender dysphoria, and quality-of-life outcomes of top surgery for trans individuals in Australia. By addressing limitations of existing research, this study aims to improve our understanding of trans people's experience accessing and receiving top surgery. The findings may guide improvements in perioperative and postoperative care and support for patients and inform policy related to gender-affirming surgeries in Australia. CI - (c) Julia Bak, Kah Aik Tan, Jack Ball, Sam Bonney, Julia K Moore, Kirsty Hird, Blake S Cavve, Larissa Marion, Tim Hewitt, Sav Zwickl, Simone Mahfouda, Ashleigh Lin, Penelope Strauss. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Bak, Julia AU - Bak J AUID- ORCID: 0009-0005-6822-534X AD - Youth Mental Health, The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia, 61 63191000. FAU - Tan, Kah Aik AU - Tan KA AUID- ORCID: 0000-0002-3053-7154 AD - South Metropolitan Health Service - Mental Health, Fiona Stanley Hospitals Group, Perth, Australia. AD - East Metropolitan Health Service - Mental Health, Royal Perth Bentley Hospitals Group, Perth, Australia. FAU - Ball, Jack AU - Ball J AUID- ORCID: 0009-0006-4726-3723 AD - Youth Mental Health, The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia, 61 63191000. FAU - Bonney, Sam AU - Bonney S AD - Youth Mental Health, The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia, 61 63191000. FAU - Moore, Julia K AU - Moore JK AUID- ORCID: 0000-0002-2313-7048 AD - The Gender Diversity Service, Child and Adolescent Health Service - Mental Health, Perth Children's Hospital, Perth, Australia. FAU - Hird, Kirsty AU - Hird K AUID- ORCID: 0000-0001-7677-2128 AD - The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia. FAU - Cavve, Blake S AU - Cavve BS AUID- ORCID: 0000-0002-3548-6181 AD - Youth Mental Health, The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia, 61 63191000. FAU - Marion, Larissa AU - Marion L AUID- ORCID: 0000-0002-8244-6588 AD - School of Psychological Science, The University of Western Australia, Perth, Australia. FAU - Hewitt, Tim AU - Hewitt T AUID- ORCID: 0009-0003-0989-9470 AD - Fellow of the Royal Australasian College of Surgeons, Perth, Australia. AD - Child and Adolescent Health Service, Perth Children's Hospital, Perth, Australia. FAU - Zwickl, Sav AU - Zwickl S AUID- ORCID: 0000-0003-2959-5928 AD - Youth Mental Health, The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia, 61 63191000. AD - Department of Medicine (Austin Health), Trans Health Research Group, The University of Melbourne, Perth, Australia. FAU - Mahfouda, Simone AU - Mahfouda S AUID- ORCID: 0000-0002-1501-3926 AD - Department of Clinical Psychology, Acute Adult Inpatient Services, Graylands Hospital, Perth, Australia. FAU - Lin, Ashleigh AU - Lin A AUID- ORCID: 0000-0002-4054-0242 AD - School of Population and Global Health, The University of Western Australia, Perth, Australia. AD - Australian Research Centre in Sex, Health and Society, La Trobe University, Melbourne, Australia. FAU - Strauss, Penelope AU - Strauss P AUID- ORCID: 0000-0002-4828-0983 AD - Youth Mental Health, The Kids Research Institute Australia, 15 Hospital Ave, Nedlands WA 6009, Perth, Australia, 61 63191000. AD - School of Population and Global Health, The University of Western Australia, Perth, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260821 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Male MH - *Quality of Life/psychology MH - Female MH - *Gender Dysphoria/psychology MH - Prospective Studies MH - *Transgender Persons/psychology MH - *Mental Health MH - Surveys and Questionnaires MH - Adult MH - *Gender-Affirming Surgery/psychology MH - Adolescent MH - Western Australia MH - Longitudinal Studies MH - Gender-Nonconforming Persons PMC - PMC13496940 OTO - NOTNLM OT - chest reconstruction OT - gender affirmation OT - gender dysphoria OT - top surgery OT - transgender COIS- Conflicts of Interest: TH is a surgeon who performs top surgery in Western Australia and is a recruitment site for this study. TH contributed to the study design primarily through co-developing the surgical pro formas and informing on the ideal timing of questionnaire delivery for participants. TH will be aware of the identity of participants as he will complete the surgical pro formas for participants. However, TH will not have access to the raw data collected through the participant questionnaires, to preserve participant privacy and ensure that participants feel free to answer the questionnaires freely. EDAT- 2026/08/21 17:37 MHDA- 2026/08/21 17:38 PMCR- 2026/08/21 CRDT- 2026/08/21 15:53 PHST- 2025/09/10 00:00 [received] PHST- 2026/04/20 00:00 [revised] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/08/21 17:38 [medline] PHST- 2026/08/21 17:37 [pubmed] PHST- 2026/08/21 15:53 [entrez] PHST- 2026/08/21 00:00 [pmc-release] AID - v15i1e83928 [pii] AID - 83928 [pii] AID - 10.2196/83928 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Aug 21;15:e83928. doi: 10.2196/83928. PMID- 42627948 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260823 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 28 DP - 2026 Aug 21 TI - Co-Designing a Clinician-Centered Video Gait Assessment System for Cerebral Palsy Based on the Framework for Co-Design of Clinical Practice Tools: Iterative Development and Formative Evaluation Study. PG - e92823 LID - 10.2196/92823 [doi] LID - e92823 AB - BACKGROUND: Clinical gait assessment is essential for monitoring functional progress in children with cerebral palsy (CP); however, traditional visual observation remains inherently subjective and labor-intensive. Although AI-supported video gait assessment may provide more objective and automated outputs, many tools remain difficult to integrate into routine clinical workflows. OBJECTIVE: This study aimed to iteratively develop and evaluate a clinician-centered, automated gait analysis system for children with CP by using a structured co-design process, ensuring the tool effectively supports clinical decision-making and integrates into routine practice. METHODS: This study adopted the Framework for Co-design of Clinical Practice Tools (FRESCO) to guide a 5-step iterative development process. A multidisciplinary advisory group, comprising rehabilitation physicians, therapists, biomechanics experts, and human factors engineers, collaborated throughout the study. The process involved the following: (1) identifying baseline clinical needs and initial system requirements through advisory group input and review of existing gait-analysis systems; (2) developing an initial system prototype based on these requirements; (3) conducting think-aloud evaluations and System Usability Scale (SUS) assessments with 19 rehabilitation professionals to identify usability barriers, additional user requirements, and prototype refinement needs; (4) testing workflow integration and safety in clinical simulations with 12 rehabilitation professionals; and (5) finalizing prototype specifications, workflow procedures, and implementation guidelines through a consensus workshop. RESULTS: By targeting workflow alignment, interpretability, and the delivery of useful system outputs, the iterative co-design process supported progressive prototype refinement. The baseline needs-identification phase generated initial system requirements across system content, workflow integration, and clinical usability support, which informed the first prototype. The think-aloud phase demonstrated good perceived usability (SUS score: mean 75.8, SD 7.5) and identified additional refinement needs related to functional expansion, report interpretability, and workflow compatibility. In the clinical simulation phase, the prototype was perceived as stable and safe for use in routine clinical settings, with no safety incidents observed, while also revealing implementation needs related to video capture and output interpretation. This work culminated in 2 key outputs: a refined prototype ready for large-scale clinical testing and a comprehensive implementation guideline. Conceptually, the study articulated two data-informed design principles: (1) supporting workflow-compatible implementation by minimizing technical and operational barriers, and (2) prioritizing clinical autonomy and actionability. CONCLUSIONS: FRESCO provided a structured approach for narrowing the gap between technical feasibility and clinical utility in the development of a clinician-centered video gait assessment system. By iteratively involving a multidisciplinary team, we transformed a video-based analysis tool into a stable, interpretable, and workflow-compatible decision-support prototype. Broadly, the identified design principles may provide practical reference points for developing clinician-centered digital health tools intended to support clinical decision-making in routine practice. CI - (c) Xi Gao, Xingye Cheng, Jiming Sun, Wenqi Liang, Stacey Reading, Yanxin Zhang. Originally published in the Journal of Medical Internet Research (https://www.jmir.org). FAU - Gao, Xi AU - Gao X AUID- ORCID: 0009-0000-8939-4234 AD - School of Exercise, Sport and Rehabilitation Sciences, Faculty of Science, University of Auckland, Bldg 907, 368 Khyber Pass, Auckland, 1023, New Zealand, 64 9 3737599 ext 86859. FAU - Cheng, Xingye AU - Cheng X AUID- ORCID: 0009-0001-5246-6174 AD - School of Exercise, Sport and Rehabilitation Sciences, Faculty of Science, University of Auckland, Bldg 907, 368 Khyber Pass, Auckland, 1023, New Zealand, 64 9 3737599 ext 86859. FAU - Sun, Jiming AU - Sun J AUID- ORCID: 0009-0004-5095-394X AD - Qingdao Eber Hospital, Qingdao, Shandong, China. FAU - Liang, Wenqi AU - Liang W AUID- ORCID: 0000-0002-6814-9958 AD - School of Exercise, Sport and Rehabilitation Sciences, Faculty of Science, University of Auckland, Bldg 907, 368 Khyber Pass, Auckland, 1023, New Zealand, 64 9 3737599 ext 86859. FAU - Reading, Stacey AU - Reading S AUID- ORCID: 0000-0001-8852-4607 AD - School of Exercise, Sport and Rehabilitation Sciences, Faculty of Science, University of Auckland, Bldg 907, 368 Khyber Pass, Auckland, 1023, New Zealand, 64 9 3737599 ext 86859. FAU - Zhang, Yanxin AU - Zhang Y AUID- ORCID: 0000-0002-7638-1669 AD - School of Exercise, Sport and Rehabilitation Sciences, Faculty of Science, University of Auckland, Bldg 907, 368 Khyber Pass, Auckland, 1023, New Zealand, 64 9 3737599 ext 86859. LA - eng PT - Journal Article DEP - 20260821 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 SB - IM MH - *Cerebral Palsy/physiopathology MH - Humans MH - *Gait MH - *Video Recording MH - *Gait Analysis/methods MH - Child PMC - PMC13496319 OTO - NOTNLM OT - cerebral palsy OT - co-design OT - decision-support system OT - gait analysis OT - human factors OT - rehabilitation COIS- Conflicts of Interest: XG and XC were involved in the development of the gait analysis system evaluated in this study. The remaining authors declare no other financial or nonfinancial competing interests. EDAT- 2026/08/21 17:37 MHDA- 2026/08/21 17:38 PMCR- 2026/08/21 CRDT- 2026/08/21 14:13 PHST- 2026/02/04 00:00 [received] PHST- 2026/06/14 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/08/21 17:38 [medline] PHST- 2026/08/21 17:37 [pubmed] PHST- 2026/08/21 14:13 [entrez] PHST- 2026/08/21 00:00 [pmc-release] AID - v28i1e92823 [pii] AID - 92823 [pii] AID - 10.2196/92823 [doi] PST - epublish SO - J Med Internet Res. 2026 Aug 21;28:e92823. doi: 10.2196/92823. PMID- 42627606 OWN - NLM STAT- Publisher LR - 20260821 IS - 1720-8386 (Electronic) IS - 0391-4097 (Linking) DP - 2026 Aug 21 TI - Interpreting the GnRH stimulation test in girls with central precocious puberty: the role of age and body mass index. LID - 10.1007/s40618-026-03027-7 [doi] AB - PURPOSE: The gonadotropin-releasing hormone (GnRH) stimulation test is the reference standard for diagnosing central precocious puberty (CPP), yet its reliability may vary with age and body mass index (BMI). This study evaluated the diagnostic performance of GnRH test parameters in girls with suspected CPP and examined the influence of age and BMI on their clinical interpretation. METHODS: This retrospective study included 98 girls who underwent GnRH stimulation testing between January 2023 and December 2025 at a tertiary pediatric endocrinology center. Auxological data, basal luteinizing hormone (LH), stimulated LH at 40 min (LH(4)(0)), stimulated LH/FSH ratio (sLH/FSH), bone age advancement (BAA), and pelvic ultrasonographic measurements were recorded. Final CPP diagnosis based on longitudinal follow-up served as the reference outcome. ROC analyses, age- and BMI-stratified evaluations, and multivariable logistic regression were performed. RESULTS: Thirty-six girls (36.7%) were diagnosed with CPP, and all initiated GnRHanalogue treatment. LH(4)(0) showed the highest diagnostic performance (AUC = 0.738); a cut-off of 4.65 IU/L yielded 91.2% sensitivity and 61.7% specificity. Basal LH had limited accuracy (AUC = 0.668), and ultrasonographic parameters showed poor discrimination. LH(4)(0) and BAA were independently associated with CPP. Diagnostic performance varied by age, with excellent discrimination in girls < 6 years (AUC = 1.000) and moderate accuracy at 6-8 years (AUC = 0.738). Increasing BMI was associated with reduced discriminatory capacity of LH(4)(0), while uterine length showed relatively higher performance in girls with obesity. CONCLUSION: The diagnostic performance of the GnRH stimulation test varied with age and BMI and was lower in older girls and those with obesity. LH(4)(0) was the most informative hormonal parameter, but should not be interpreted in isolation. Test results should be integrated with clinical progression, auxological findings, skeletal maturation, biochemical data, and imaging when clinically indicated. CI - (c) 2026. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE). FAU - Hurmuzlu Kozler, Selen AU - Hurmuzlu Kozler S AUID- ORCID: 0000-0001-6533-2944 AD - Department of Pediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Turkey. selenhurmuzlu@gmail.com. FAU - Kilci, Fatih AU - Kilci F AD - Department of Pediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Turkey. FAU - Sarikaya, Emre AU - Sarikaya E AD - Department of Pediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Turkey. FAU - Ozcan Murat, Nurhan AU - Ozcan Murat N AD - Department of Pediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Turkey. LA - eng PT - Journal Article DEP - 20260821 PL - Italy TA - J Endocrinol Invest JT - Journal of endocrinological investigation JID - 7806594 SB - IM OTO - NOTNLM OT - Body mass index OT - Central precocious puberty OT - Diagnostic performance OT - GnRH stimulation test OT - Luteinizing hormone OT - Pelvic ultrasonography COIS- Declarations. Conflict of interest: The authors have no relevant financial or non-financial interests to disclose. Ethical approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Kocaeli City Hospital (No:2026/27). Informed consent: was waived due to the use of anonymized retrospective data. EDAT- 2026/08/21 17:37 MHDA- 2026/08/21 17:37 CRDT- 2026/08/21 11:18 PHST- 2026/06/13 00:00 [received] PHST- 2026/08/09 00:00 [accepted] PHST- 2026/08/21 17:37 [medline] PHST- 2026/08/21 17:37 [pubmed] PHST- 2026/08/21 11:18 [entrez] AID - 10.1007/s40618-026-03027-7 [pii] AID - 10.1007/s40618-026-03027-7 [doi] PST - aheadofprint SO - J Endocrinol Invest. 2026 Aug 21. doi: 10.1007/s40618-026-03027-7. PMID- 42627241 OWN - NLM STAT- Publisher LR - 20260831 IS - 1531-698X (Electronic) IS - 1040-8703 (Linking) DP - 2026 Aug 31 TI - From Jones to avulsion: rethinking the fifth metatarsal base. LID - 10.1097/MOP.0000000000001615 [doi] AB - PURPOSE OF REVIEW: Fifth metatarsal fractures are the most common metatarsal injury in the pediatric population; however, their management is frequently extrapolated from adult protocols. This review explores the emergence of pediatric-specific classification systems and evolving evidence on surgical versus conservative treatment in skeletally immature patients. RECENT FINDINGS: Anatomical and developmental differences critically distinguish pediatric fractures from adult fractures. Recent pediatric classifications, including those by Herrera-Soto and Lee, improve upon the widely used Dameron/Lawrence-Botte system by recognizing the apophysis as a distinct entity and offering better prognostic correlation. Zone 1 avulsion fractures achieve near-universal healing with conservative management. Emerging evidence supports surgical fixation with intramedullary screws for Zone 2 (Jones) fractures in adolescent athletes, whereas prepubertal patients respond well to conservative treatment. Nutritional factors, particularly vitamin D deficiency and inadequate calcium intake, are increasingly being recognized as modifiable risk factors for stress fractures and delayed union. SUMMARY: The management of fifth metatarsal fractures should be individualized according to the fracture zone, skeletal maturity, and activity level. Pediatric-specific classifications offer improved diagnostic accuracy. Nutritional optimization should be integrated into comprehensive management protocols, and further pediatric-focused clinical trials are needed. CI - Copyright (c) 2026 Wolters Kluwer Health, LLC. All rights reserved. FAU - Sepulveda, Matias AU - Sepulveda M AD - Universidad Austral de Chile. AD - Hospital Base de Valdivia. AD - Clinica Alemana Valdivia, Valdivia, Chile. FAU - Gutierrez, Gabriel AU - Gutierrez G AD - Hospital Base de Valdivia. AD - Clinica Alemana Valdivia, Valdivia, Chile. FAU - Birrer, Estefania AU - Birrer E AD - Universidad Austral de Chile. AD - Hospital Base de Valdivia. AD - Clinica Alemana Valdivia, Valdivia, Chile. LA - eng PT - Journal Article DEP - 20260831 PL - United States TA - Curr Opin Pediatr JT - Current opinion in pediatrics JID - 9000850 SB - IM OTO - NOTNLM OT - Jones fracture OT - apophysis OT - avulsion fracture OT - fifth metatarsal fracture OT - pediatric fracture EDAT- 2026/08/21 11:39 MHDA- 2026/08/21 11:39 CRDT- 2026/08/21 10:03 PHST- 2026/08/21 11:39 [pubmed] PHST- 2026/08/21 11:39 [medline] PHST- 2026/08/21 10:03 [entrez] AID - 00008480-990000000-00389 [pii] AID - 10.1097/MOP.0000000000001615 [doi] PST - aheadofprint SO - Curr Opin Pediatr. 2026 Aug 31. doi: 10.1097/MOP.0000000000001615. PMID- 42626294 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260926 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Hunger, satiety, and eating behavior after craniopharyngioma - narrative review on current management and future therapeutic perspectives. PG - 1895026 LID - 10.3389/fendo.2026.1895026 [doi] LID - 1895026 AB - Craniopharyngiomas are low-grade, intracranial tumors frequently associated with dysfunction of the hypothalamic-pituitary axes and the development of obesity. This narrative review aimed to evaluate the potential contribution of eating behaviors, while also identifying perspectives for future therapeutic intervention. Searches were performed across five bibliographic databases. All peer-reviewed published studies involving childhood-onset or adult-onset craniopharyngioma populations were considered eligible when they examined eating behavior in relation to pharmacological or surgical interventions, neuroimaging, endocrine responses, energy expenditure, sleep, and/or neuropsychological outcomes. The available evidence regarding eating behavior in individuals with craniopharyngioma was limited, with only 10 of the 82 included studies employing validated measures of eating behavior. Eating behavior was assessed as a primary outcome in seven studies, as a secondary outcome in twelve studies, and discussed without formal measurement in thirty-one studies. Only one randomized controlled trial with the melanocortin-4 receptor (MC4R) agonist setmelanotide was identified that successfully targeted eating behavior (hyperphagia) modification and achieved significant weight loss as an intervention for craniopharyngioma-related obesity. Greater insight into eating behavior in this population, supported by long-term studies using validated assessment tools, is required to clarify the mechanisms underlying craniopharyngioma-associated obesity and confirm effectiveness and tolerability of medical treatment with MC4R-agonists. CI - Copyright (c) 2026 Muller. FAU - Muller, Hermann L AU - Muller HL AD - Department of Pediatrics and Pediatric Hematology/Oncology, University Children's Hospital, Carl von Ossietzky Universitat, Klinikum Oldenburg AoR, Oldenburg, Germany. LA - eng PT - Journal Article PT - Review DEP - 20260806 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Craniopharyngioma/therapy/complications/physiopathology MH - *Pituitary Neoplasms/therapy/complications/physiopathology MH - *Feeding Behavior/physiology MH - *Hunger/physiology MH - *Satiation/physiology MH - Obesity/etiology PMC - PMC13491036 OTO - NOTNLM OT - craniopharyngioma OT - eating behavior OT - hunger OT - hypothalamus OT - obesity OT - quality of life OT - satiety OT - setmelanotide COIS- HM has received reimbursement of participation fees for scientific meetings and continuing medical education events, and reimbursement of travel expenses and lecture honoraria from Rhythm Pharmaceuticals. HM is specialty chief editor for the journal Frontiers in Endocrinology - Pituitary Endocrinology, guest associate editor for Frontiers Obesity and Frontiers Pediatric Endocrinology, and editorial board member of biomedicines mdpi. The author HM declared that he was an editorial board member of Frontiers at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/08/21 11:39 MHDA- 2026/08/21 11:40 PMCR- 2026/08/06 CRDT- 2026/08/21 06:02 PHST- 2026/05/29 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/21 11:40 [medline] PHST- 2026/08/21 11:39 [pubmed] PHST- 2026/08/21 06:02 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 10.3389/fendo.2026.1895026 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Aug 6;17:1895026. doi: 10.3389/fendo.2026.1895026. eCollection 2026. PMID- 42626224 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260821 LR - 20260910 IS - 2219-2808 (Print) IS - 2219-2808 (Electronic) IS - 2219-2808 (Linking) VI - 15 IP - 3 DP - 2026 Sep 9 TI - Association of Helicobacter pylori infection with insulin resistance, tumor necrosis factor-alpha, and dyslipidemia in obese children with metabolic syndrome. PG - 121926 LID - 10.5409/wjcp.v15.i3.121926 [doi] LID - 121926 AB - BACKGROUND: Previous studies have suggested a link between Helicobacter pylori (H. pylori) and metabolic complications outside the gastrointestinal tract, but the relationship with pediatric obesity remains unclear. We aim to study the correlation between H. pylori infection and components of insulin resistance (IR), inflammation [tumor necrosis factor-alpha (TNF-alpha)], and cardiometabolic parameters in obese children/adolescents with a metabolic syndrome (MetS) phenotype. AIM: To elucidate the association between H. pylori infection and metabolic disturbances in children with obesity and MetS, focusing on homeostasis model assessment of IR (HOMA-IR), inflammatory markers (TNF-alpha), and the lipid profile. METHODS: The study recruited 70 obese children/adolescents with MetS phenotype from the pediatric units of Minia University Hospital from September 2023 to October 2024. H. pylori stool antigen quantitative enzyme-linked immunosorbent assay was used to classify participants into H. pylori-negative (n = 35) and H. pylori-positive (n = 35). Assessment of fasting glucose, glycated hemoglobin (HbA1c), fasting insulin, lipid profile, liver enzymes, TNF-alpha, adiponectin, and leptin, as well as other parameters, was done. IR was calculated in detail using the HOMA-IR formula (fasting insulin x fasting glucose/405). Various statistical analyses, including intergroup comparisons, correlation analyses, and receiver operating characteristic curve analyses, were also performed. RESULTS: Groups were similar in age, sex, and standardized body mass index (BMI) value. Elevated blood pressure (65.7% vs 31.4%, P = 0.004) and hepatomegaly (62.9% vs 28.6%, P = 0.004) were more common in H. pylori-positive participants. The infected group had higher alanine aminotransferase and aspartate aminotransferase (AST) levels (both P < 0.001). It had higher triglycerides and low-density lipoprotein cholesterol and lower high-density lipoprotein cholesterol (HDL) levels, indicating a more unfavorable lipid profile (all P < 0.001) and more impaired glycemic/IR indices: Fasting glucose (158.5 +/- 40.1 mg/dL vs 109.5 +/- 22.7 mg/dL, P < 0.001), HbA1c (8.5 +/- 2.2 vs 7.4 +/- 1.7, P = 0.019), fasting insulin (9.4 +/- 3.6 muIU/mL vs 3.9 +/- 1.0 muIU/mL, P < 0.001), and HOMA-IR (3.61 +/- 1.45 vs 1.06 +/- 0.36, P < 0.001). TNF-alpha was elevated in the infected group (median 7.13 vs 6.23, P = 0.011). In H. pylori-positive participants, HOMA-IR had a strong positive correlation with standardized BMI value (r = 0.889, P < 0.001) and TNF-alpha (r = 0.896, P < 0.001). HOMA-IR > 1.67 had excellent sensitivity and specificity for detecting H. pylori positivity [area under the curve (AUC): 0.954; sensitivity 88.6%, specificity 97.1%], and TNF-alpha had moderate sensitivity (AUC: 0.677). CONCLUSION: H. pylori positivity was linked to elevated IR, TNF-alpha, atherogenic dyslipidemia, and a greater hepatic/clinical metabolic burden in the MetS phenotype of obesity in children and adolescents. More longitudinal studies that will help control socioeconomic and lifestyle confounding are warranted. CI - (c)Author(s) 2026. FAU - Ibrahim Elbakry, Noura M AU - Ibrahim Elbakry NM AD - Department of Pediatric, Faculty of Medicine, Minia University, Minia 2422998, Egypt. FAU - Hemeda, Mohamed S AU - Hemeda MS AD - Department of Forensic Medicine and Clinical Toxicology, Faculty of Medicine, Port Said University, Port Said 44654, Egypt. mohamudsadawy@med.psu.edu.eg. FAU - Mostafa Mohamed Ahmed, Ayat AU - Mostafa Mohamed Ahmed A AD - Department of Clinical Pathology and Chemistry, Faculty of Medicine, Minia University, Minia 2422998, Egypt. FAU - Adel Zaky, Hager AU - Adel Zaky H AD - Department of Public Health, Faculty of Medicine, Faculty of Medicine, Minia University, Minia 2422998, Egypt. FAU - Gamil, Aya Nabil AU - Gamil AN AD - Department of Microbiology and Immunology, Minia University, Minia 45638, Egypt. FAU - Arafat Abd Elmoaty, Abd Elmoaty AU - Arafat Abd Elmoaty AE AD - Department of Hepatology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Assiut 44654, Egypt. FAU - M Khafagi, Mahmoud AU - M Khafagi M AD - Department of Hepatology and Infectious Diseases, Faculty of Medicine, Al-Azhar University, Assiut 44654, Egypt. FAU - Mohamed Alkabeer, Ashraf AU - Mohamed Alkabeer A AD - Department of Internal Medicine, Al-Azhar University, Assiut 2422998, Egypt. FAU - Abd Elaziz Alsaid, Aldosoky AU - Abd Elaziz Alsaid A AD - Department of Internal Medicine, Al-Azhar University, Assiut 2422998, Egypt. FAU - A Elhagary, Ahmed AU - A Elhagary A AD - Department of Internal Medicine, Al-Azhar University, Assiut 2422998, Egypt. FAU - Mohammed Aboassy, Walid AU - Mohammed Aboassy W AD - Pediatric Faculty of Medicine Port Said University, Port Said 42526, Egypt. FAU - Nabil Gamil Mohammed, Ahmed AU - Nabil Gamil Mohammed A AD - Department of Pediatric, Faculty of Medicine, Minia University, Minia 2422998, Egypt. LA - eng PT - Journal Article DEP - 20260909 PL - United States TA - World J Clin Pediatr JT - World journal of clinical pediatrics JID - 101627548 PMC - PMC13491160 OTO - NOTNLM OT - Childhood obesity OT - Dyslipidemia OT - Helicobacter pylori OT - Homeostasis model assessment of insulin resistance OT - Insulin resistance OT - Metabolic syndrome phenotype OT - Tumor necrosis factor-alpha COIS- Conflict-of-interest statement: All the authors declare that they have no conflict of interest related to this study. EDAT- 2026/08/21 11:39 MHDA- 2026/08/21 11:40 PMCR- 2026/09/09 CRDT- 2026/08/21 05:58 PHST- 2026/04/07 00:00 [received] PHST- 2026/04/20 00:00 [revised] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/08/21 11:40 [medline] PHST- 2026/08/21 11:39 [pubmed] PHST- 2026/08/21 05:58 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - 10.5409/wjcp.v15.i3.121926 [doi] PST - epublish SO - World J Clin Pediatr. 2026 Sep 9;15(3):121926. doi: 10.5409/wjcp.v15.i3.121926. eCollection 2026 Sep 9. PMID- 42626192 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260821 LR - 20260822 IS - 2624-8212 (Electronic) IS - 2624-8212 (Linking) VI - 9 DP - 2026 TI - Digital twin-supported behavioral intention in mothers of young children to prevent childhood obesity: a large language model-based intervention study. PG - 1927993 LID - 10.3389/frai.2026.1927993 [doi] LID - 1927993 AB - INTRODUCTION: Childhood obesity is a major determinant of lifelong non-communicable disease risk, yet early intervention may modify this trajectory. Digital twins and large language models may provide a scalable means of translating individualized risk prediction into understandable and motivating lifestyle guidance. METHODS: We developed a precision-preventive intervention integrating a childhood-overweight digital twin with an empathic, supervised-fine-tuned open-source nutrition-guidance large language model. The model was based on Llama 3-70B and fine-tuned using the Standard Tables of Food Composition in Japan 2020 and its 2023 amendment. Response appropriateness was evaluated using 30 nutrition-related questions independently assessed by three registered dietitians. The digital twin adopted a published Tohoku Medical Megabank Birth and Three-Generation cohort model predicting overweight risk at 36-47 months, 6 years, 11 years, and 14 years. A total of 121 women with a child under 14 years of age participated in the digital-twin visualization and a single chat-based test. RESULTS: The off-the-shelf Llama 3-70B produced a mean of 18 appropriate responses out of 30, whereas the fine-tuned model produced 27 out of 30. The digital-twin visualization and chat consultation were rated highly for clarity, perceived value, behavioral intention, and willingness to continue, with core-item means above 4.9 on a five-point scale. Thematic analysis showed that 112 of 121 participants perceived the recommended lifestyle changes as feasible and achievable gradually. DISCUSSION: The integrated intervention demonstrated preliminary operational feasibility and acceptability. Individualized future-risk visualization combined with supportive conversational guidance was associated with high self-reported behavioral intention. Controlled and longitudinal studies are required to determine whether these preliminary motivational responses translate into sustained behavior change and improved health outcomes. CI - Copyright (c) 2026 Nakamura, Shinoda, Noda, Ishikuro, Obara, Matsubara, Ishii, Onishi and Ohyama. FAU - Nakamura, Kenji AU - Nakamura K AD - Center for Mathematics and Data Science, Gunma University, Maebashi, Gunma, Japan. AD - Innovative Medical Research Center, Gunma University Hospital, Maebashi, Gunma, Japan. FAU - Shinoda, Genki AU - Shinoda G AD - Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Noda, Aoi AU - Noda A AD - Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Ishikuro, Mami AU - Ishikuro M AD - Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Obara, Taku AU - Obara T AD - Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Matsubara, Taeka AU - Matsubara T AD - Interfaculty Initiative in Information Studies, The University of Tokyo, Tokyo, Japan. FAU - Ishii, Hideki AU - Ishii H AD - Department of Cardiovascular Medicine, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan. FAU - Onishi, Masahiro AU - Onishi M AD - System Integration Center, Gunma University Hospital, Maebashi, Gunma, Japan. FAU - Ohyama, Yoshiaki AU - Ohyama Y AD - Innovative Medical Research Center, Gunma University Hospital, Maebashi, Gunma, Japan. LA - eng PT - Journal Article DEP - 20260806 PL - Switzerland TA - Front Artif Intell JT - Frontiers in artificial intelligence JID - 101770551 PMC - PMC13491048 OTO - NOTNLM OT - behavioral intention OT - childhood obesity OT - digital twin OT - large language model OT - maternal and child health OT - nutrition counseling OT - precision prevention COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/21 11:39 MHDA- 2026/08/21 11:40 PMCR- 2026/08/06 CRDT- 2026/08/21 05:55 PHST- 2026/07/04 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/08/21 11:40 [medline] PHST- 2026/08/21 11:39 [pubmed] PHST- 2026/08/21 05:55 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 10.3389/frai.2026.1927993 [doi] PST - epublish SO - Front Artif Intell. 2026 Aug 6;9:1927993. doi: 10.3389/frai.2026.1927993. eCollection 2026. PMID- 42625989 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260821 LR - 20260822 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Patterns of habitual physical activity in children and adolescents with cerebral palsy (GMFCS I-II). PG - 1896196 LID - 10.3389/fspor.2026.1896196 [doi] LID - 1896196 AB - BACKGROUND: To provide tailored recommendations and interventions for physical activity in children with cerebral palsy, it is important to gain insight not only into the amount and intensity, but also into the temporal pattern of activity. This descriptive study describes postures, bouts, transitions, timepoints, frequency, and type of activity in ambulatory children with Cerebral Palsy (CP) and compare these patterns with typically developing (TD) peers. METHODS: Twenty-three children with CP [GMFCS I-II, 11 males, mean age [range] 9 years [7-16]] and 23 TD peers [9 male, mean age[range] 10 years [7-15]] wore two accelerometers for seven consecutive days. A validated human activity recognition model classified following activities; lying, sitting, standing, walking, running, cycling and jumping based on raw acceleration data. RESULTS: Both groups accumulated about five hours of daily physical activity through active postures and locomotion, predominantly through standing ( approximately 200 min) and walking ( approximately 100 min), and short periods of running ( approximately 10 min), cycling (<1 min) and jumping (1-2 min). The accumulated activity was approximately 8% for CP and 10,5% higher for TD on weekdays than weekends. Children with CP were on average approximately 10 to 17 min less active and had approximately 15% less active-sedentary-transitions compared to TD, but without statistical significance. During weekdays, all children engaged in standing bouts of up to 10 min, walking bouts of up to two minutes and running bouts of up to 24 s. During weekends, the proportion of children performing different bout lengths decreased as bout length increased. CONCLUSION: Ambulatory children with CP, predominantly classified as GMFCS I, demonstrated habitual physical activity patterns, with no statistically significant difference from TD peers. Additionally, there was no statistically significant difference between weekdays and weekends for either group. Substantial within-group variation highlights the heterogeneity of habitual physical activity patterns in children. Furthermore, given small sample size and low statistical power, these findings should be regarded as descriptive and hypothesis-generating. CI - (c) 2026 Torring, Roeleveld, Lydersen, Bardal and Braendvik. FAU - Torring, Marte Fossflaten AU - Torring MF AD - Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway. AD - Physiotherapy Unit, Trondheim Municipal, Trondheim, Norway. FAU - Roeleveld, Karin AU - Roeleveld K AD - Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway. FAU - Lydersen, Stian AU - Lydersen S AD - Regional Centre for Child and Youth - Mental Health and Child Welfare, Department of Mental Health, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway. FAU - Bardal, Ellen Marie AU - Bardal EM AD - Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway. AD - Clinic of Rehabilitation, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. FAU - Braendvik, Siri Merete AU - Braendvik SM AD - Department of Neuromedicine and Movement Science, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, NTNU, Trondheim, Norway. AD - Clinic of Rehabilitation, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. LA - eng PT - Journal Article DEP - 20260731 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13491053 OTO - NOTNLM OT - activity patterns OT - activity types OT - cerebral palsy OT - habitual physical activity OT - human activity recognition COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/21 11:39 MHDA- 2026/08/21 11:40 PMCR- 2026/07/31 CRDT- 2026/08/21 05:42 PHST- 2026/05/31 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/08/21 11:40 [medline] PHST- 2026/08/21 11:39 [pubmed] PHST- 2026/08/21 05:42 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - 10.3389/fspor.2026.1896196 [doi] PST - epublish SO - Front Sports Act Living. 2026 Jul 31;8:1896196. doi: 10.3389/fspor.2026.1896196. eCollection 2026. PMID- 42625773 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260821 LR - 20260822 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 13 DP - 2026 TI - A descriptive cross-sectional study on the dry eye disease in children in Xiamen, China. PG - 1897928 LID - 10.3389/fmed.2026.1897928 [doi] LID - 1897928 AB - OBJECTIVE: To evaluate the clinical characteristics, risk factors, and applicability of three commonly used dry eye disease (DED) questionnaires (OSDI, CDEQ, and COCI) in children and adolescents in Xiamen, China, aiming to provide preliminary descriptive data in DED pediatric population. METHODS: This single-center cross-sectional study included 105 pediatric patients with DED. Demographic data, clinical findings, risk factors, and questionnaire scores were collected. Univariate analysis was used to identify associated factors. Internal consistency was assessed using Cronbach's alpha, inter-questionnaire correlations using Spearman analysis, and discriminative validity using Kruskal-Wallis and Mann-Whitney U tests. RESULTS: Among 105 participants (mean age 7.86 +/- 3.13 years; 64.76% male), the majority were elementary school-aged (54.29%). All patients exhibited meibomian gland dysfunction, and 92.38% had mixed-type DED. Age (p = 0.012), BMI (p = 0.067), outdoor activity (p = 0.029), and sleep duration (p = 0.055) were associated with DED subtype or severity. The response rates of the CDEQ and COCI were 100%. All questionnaires showed acceptable internal consistency (Cronbach's alpha = 0.642-0.919) and moderate correlations. However, none demonstrated significant discriminative ability for DED severity (p > 0.05). CONCLUSION: Given the cross-sectional design, no causal inference can be drawn from these findings. Within this descriptive framework, mixed-type DED with predominant MGD emerged as the main subtype in children in Xiamen. Obesity, limited outdoor activity, and short sleep duration were identified as potential correlates. The CDEQ and COCI showed acceptable feasibility and reliability, while the OSDI demonstrated limited applicability. None of the three questionnaires effectively distinguished severity, underscoring the need for pediatric-specific tools. CI - Copyright (c) 2026 Fang, Sun, Xiong, Yin, Yang and Bu. FAU - Fang, Weifang AU - Fang W AD - Department of Ophthalmology, Xiamen Children's Hospital (Children's Hospital of Fudan University at Xiamen), Xiamen Key Laboratory of Pediatric General Surgery Diseases, Xiamen, China. FAU - Sun, Le AU - Sun L AD - Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China. FAU - Xiong, Weiwei AU - Xiong W AD - Department of Ophthalmology, Xiamen Children's Hospital (Children's Hospital of Fudan University at Xiamen), Xiamen Key Laboratory of Pediatric General Surgery Diseases, Xiamen, China. FAU - Yin, Xue AU - Yin X AD - Department of Ophthalmology, Xiamen Children's Hospital (Children's Hospital of Fudan University at Xiamen), Xiamen Key Laboratory of Pediatric General Surgery Diseases, Xiamen, China. FAU - Yang, Hui AU - Yang H AD - Department of Ophthalmology, Xiamen Children's Hospital (Children's Hospital of Fudan University at Xiamen), Xiamen Key Laboratory of Pediatric General Surgery Diseases, Xiamen, China. FAU - Bu, Jinghua AU - Bu J AD - Department of Ophthalmology, Xiang'an Hospital of Xiamen University, Eye Institute of Xiamen University, Fujian Provincial Key Laboratory of Ophthalmology and Visual Science, Fujian Engineering and Research Center of Eye Regenerative Medicine, School of Medicine, Xiamen University, Xiamen, Fujian, China. LA - eng PT - Journal Article DEP - 20260806 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC13490148 OTO - NOTNLM OT - CDEQ OT - COCI OT - OSDI OT - dry eye disease OT - pediatric dry eye disease OT - questionnaire COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/21 11:39 MHDA- 2026/08/21 11:40 PMCR- 2026/08/06 CRDT- 2026/08/21 05:21 PHST- 2026/06/02 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/21 11:40 [medline] PHST- 2026/08/21 11:39 [pubmed] PHST- 2026/08/21 05:21 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 10.3389/fmed.2026.1897928 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Aug 6;13:1897928. doi: 10.3389/fmed.2026.1897928. eCollection 2026. PMID- 42625158 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260909 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Aug 20 TI - Addressing insufficient physical activity in children with obesity in a 4-month physical activity on prescription intervention: a single-group pre-post study. LID - 10.1186/s12889-026-29071-9 [doi] LID - 2407 AB - BACKGROUND: Childhood obesity is a complex disease and a growing global public health challenge. Physical activity on prescription (PAP) is an evidence-based method to increase physical activity (PA) in adults but has been sparsely studied in children with obesity. The aim of the study was to explore changes in PA patterns in 6-12-year-old children with obesity after a 4-month PAP intervention and to explore age- and sex-related differences. METHODS: The cohort consisted of 42 children (20 boys), 6-12 years old, treated at paediatric or rehabilitation clinics in Gothenburg and surrounding municipalities, Sweden. An individualised PAP intervention was provided, comprising individual counselling, a written prescription with an individually tailored PA recommendation, and structured follow-up. Main activities performed by the children were ball sports, swimming and walking, the latter including daily walks to and from school. Physical activity was measured using accelerometers attached to the participants' hips for 7 days before and after the intervention. Changes pre- to post-intervention in PA patterns were analysed using Wilcoxon's signed rank test. RESULTS: Of the 42 included children, 35 completed the intervention (dropout rate 16.7%), of whom 32 provided valid accelerometer data. The sample was balanced by sex (16 girls/16 boys) and age (n = 16 in each subgroup). No significant changes were observed in PA patterns in the overall group or in subgroup analyses by sex and age. Overall satisfaction with the PAP treatment was high among both children and parents. CONCLUSIONS: Although no significant changes in PA patterns were observed post-intervention, children and parents expressed satisfaction with the PAP intervention. The lack of significant findings may partly be explained by the small sample size and limited statistical power, the extent and duration of the intervention, and the limited ability of accelerometers to capture certain types of activities. Further research is needed to explore the feasibility, adherence, and long-term effects of PAP interventions in children with obesity, with implications for broader public health efforts. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04847271, registered 14 April 2021. CI - (c) 2026. The Author(s). FAU - Tornqvist, Jessica AU - Tornqvist J AUID- ORCID: 0009-0007-3775-7364 AD - Centre for Physical Activity, Region Vastra Gotaland, Gothenburg, Sweden. AD - Unit of Physiotherapy, Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Lauruschkus, Katarina AU - Lauruschkus K AUID- ORCID: 0000-0002-1801-8503 AD - Faculty of Medicine, Department of Health Sciences, Lund University, Lund, Sweden. AD - Faculty of Health Sciences, Kristianstad University, Kristianstad, Sweden. FAU - Bernhardsson, Susanne AU - Bernhardsson S AUID- ORCID: 0000-0001-8212-7678 AD - Unit of Physiotherapy, Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Research, Education, Development and Innovation, Primary Health Care, Region Vastra Gotaland, Gothenburg, Sweden. FAU - Melin, Karin AU - Melin K AUID- ORCID: 0000-0002-3297-7735 AD - Gillberg Neuropsychiatry Centre, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Department of Paediatric Neurology and Psychiatry, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden. FAU - Karlsson, Li AU - Karlsson L AUID- ORCID: 0009-0000-7660-0828 AD - Centre for Physical Activity, Region Vastra Gotaland, Gothenburg, Sweden. AD - Unit of Physiotherapy, Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Arvidsson, Daniel AU - Arvidsson D AUID- ORCID: 0000-0002-3112-5434 AD - Centre for Health and Performance, Department of Food and Nutrition, and Sport Science, University of Gothenburg, Gothenburg, Sweden. FAU - Fridolfsson, Jonatan AU - Fridolfsson J AUID- ORCID: 0000-0002-7003-4025 AD - Center for Lifestyle Intervention, Department of Molecular and Acute Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Department of MGAO, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden. FAU - Greven, Christian AU - Greven C AUID- ORCID: 0009-0009-4745-1582 AD - Centre for Health and Performance, Department of Food and Nutrition, and Sport Science, University of Gothenburg, Gothenburg, Sweden. AD - Department of MGAO, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden. FAU - Lundqvist, Stefan AU - Lundqvist S AUID- ORCID: 0000-0002-3467-8499 AD - Centre for Physical Activity, Region Vastra Gotaland, Gothenburg, Sweden. stefan.lundqvist@gu.se. AD - Unit of Physiotherapy, Department of Health and Rehabilitation, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. stefan.lundqvist@gu.se. AD - Research, Education, Development and Innovation, Primary Health Care, Region Vastra Gotaland, Gothenburg, Sweden. stefan.lundqvist@gu.se. LA - eng SI - ClinicalTrials.gov/NCT04847271 PT - Clinical Trial PT - Journal Article DEP - 20260820 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Child MH - Female MH - Humans MH - Male MH - Accelerometry MH - *Exercise MH - *Health Promotion/methods MH - *Pediatric Obesity/therapy MH - Sweden PMC - PMC13495397 OTO - NOTNLM OT - Accelerometry OT - Paediatric obesity OT - Physical Activity on Prescription OT - Physical activity OT - Sedentary behaviour COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the ethical principles described in the Declaration of Helsinki and was approved by the Swedish Ethical Review Authority (reference no 2021-03632, 2021-06810-02). Written and verbal informed consent were collected from participating parents and verbal assent from the children. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/08/21 05:35 MHDA- 2026/08/21 05:36 PMCR- 2026/08/20 CRDT- 2026/08/21 00:20 PHST- 2026/01/22 00:00 [received] PHST- 2026/08/13 00:00 [accepted] PHST- 2026/08/21 05:36 [medline] PHST- 2026/08/21 05:35 [pubmed] PHST- 2026/08/21 00:20 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - 10.1186/s12889-026-29071-9 [pii] AID - 29071 [pii] AID - 10.1186/s12889-026-29071-9 [doi] PST - epublish SO - BMC Public Health. 2026 Aug 20;26(1):2407. doi: 10.1186/s12889-026-29071-9. PMID- 42624607 OWN - NLM STAT- MEDLINE DCOM- 20260820 LR - 20260827 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 8 DP - 2026 Aug 19 TI - Reassessing mid-upper arm circumference thresholds for predicting nutritional status and pregnancy outcomes among pregnant adolescents in Bundibugyo District, Uganda: protocol for a health facility-based prospective cohort study. PG - e121400 LID - 10.1136/bmjopen-2026-121400 [doi] LID - e121400 AB - INTRODUCTION: In 2023, Sub-Saharan Africa recorded the world's highest teenage pregnancy rate of 4.4 per 1000 women compared with the global average of 1.5 per 1000, highlighting the need for accurate nutritional assessment during pregnancy. Current mid-upper arm circumference (MUAC) thresholds differ between non-pregnant adolescents (18.5 cm) and pregnant adolescents (23 cm) as per the Uganda Integrated Management of Acute Malnutrition guidelines. This classification can lead to inadequate treatment and mislabelling of adolescents as non-responders, despite nutritional improvements. This study will reassess MUAC thresholds for predicting nutritional status and pregnancy outcomes among pregnant adolescents in Bundibugyo District, Uganda. METHODS AND ANALYSIS: This health facility-based prospective cohort study will target 241 pregnant women comprising 121 pregnant adolescents (10-19 years) and 120 adults (20-49 years) in their first trimester (/= 5.6 mmol/L were randomly selected from 210 participants, alongside 60 matched healthy controls (FPG < 5.6 mmol/L). Semiquantitative lipidomics was performed, and lipid ratios were calculated from identified characteristic lipids. Univariate and multiple regression analyses were conducted. RESULTS: After adjusting for age, sex, body mass index (BMI), early-life risk factors, and metabolic disorder factors, six lipid species remained independently associated with FPG variations (Bonferroni-adjusted p < 0.05). Lipid ratios derived from these six lipids differed significantly between groups; the decreased levels of phosphatidylethanolamine/diacyl-phosphatidylcholine was significantly correlated with elevated FPG, whereas elevated levels of ether-phosphoatidylcholine/diacyl-phosphoatidylcholine ratios was significantly associated with elevated FPG. Three phosphatidylcholine species showed good diagnostic performance (AUC = 0.811, 95% CI: 0.733-0.881). Their composite signature outperformed both the baseline model (age, sex; AUC: 0.882 vs. 0.584, DeLong's p < 0.001), and the extended risk factor model (age, sex, BMI, and early-life riskr factors, AUC: 0.882 vs. 0.635, DeLong's p < 0.001). The robustness of the three PCs was further supported by sensitivity analyses, which demonstrated consistent performance using Firth penalized regression (AUC = 0.883) and an alternative FPG cutoff at the 75th percentile (AUC = 0.834). CONCLUSIONS: In this cross-sectional targeted lipidomics study, a three PC lipid panel was independently associated with subclinical hyperglycemia in preschool-aged children and showed robust diagnostic performance. Two lipid ratios were also associated with FPG. These findings identify a potential lipid panel for early risk detection in this understudied population, pending validation in larger cohorts. CI - Copyright (c) 2026 Zhang, Wang, Lv, Huang, Guo, Jiang, Zhang, Liu and Chen. FAU - Zhang, Haifeng AU - Zhang H AD - Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Wang, Jing AU - Wang J AD - Tianjin Women and Children's Health Center, Tianjin, China. FAU - Lv, Yueguang AU - Lv Y AD - Key Laboratory of Consumer Product Quality Safety Inspection and Risk Assessment, State Administration for Market Regulation, Beijing, China. FAU - Huang, Yiying AU - Huang Y AD - Department of Epidemiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Guo, Yuanyuan AU - Guo Y AD - Tianjin Women and Children's Health Center, Tianjin, China. FAU - Jiang, Chang AU - Jiang C AD - Tianjin Women and Children's Health Center, Tianjin, China. FAU - Zhang, Ting AU - Zhang T AD - Beijing Municipal Key Laboratory of Child Development and Nutriomics, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Liu, Gongshu AU - Liu G AD - Tianjin Women and Children's Health Center, Tianjin, China. FAU - Chen, Fangfang AU - Chen F AD - Department of Epidemiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. LA - eng PT - Journal Article DEP - 20260805 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Phosphatidylcholines) RN - 0 (Blood Glucose) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Hyperglycemia/diagnosis/blood MH - Male MH - Pilot Projects MH - Cross-Sectional Studies MH - Child, Preschool MH - *Phosphatidylcholines/blood MH - Blood Glucose/analysis/metabolism MH - *Biomarkers/blood MH - Lipidomics PMC - PMC13485523 OTO - NOTNLM OT - diagnostic signature OT - glycerophopholipids OT - lipid ratio OT - lipidomics OT - pediatric hyperglycemia COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/20 11:41 MHDA- 2026/08/20 11:42 PMCR- 2026/08/05 CRDT- 2026/08/20 07:32 PHST- 2026/05/11 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/08/20 11:42 [medline] PHST- 2026/08/20 11:41 [pubmed] PHST- 2026/08/20 07:32 [entrez] PHST- 2026/08/05 00:00 [pmc-release] AID - 10.3389/fendo.2026.1878086 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Aug 5;17:1878086. doi: 10.3389/fendo.2026.1878086. eCollection 2026. PMID- 42620310 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260820 LR - 20260821 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Effect of a theory-based coach education program on the objectively assessed motivational climate in grassroots football across four European countries: results from the Promoting Adolescent Physical Activity (PAPA) project. PG - 1563931 LID - 10.3389/fpsyg.2026.1563931 [doi] LID - 1563931 AB - INTRODUCTION: This study examined the longitudinal effects of the Empowering Coaching program, designed to promote more adaptive motivational climates as created by coaches in grassroots youth football across different countries. METHODS: Sixty-eight coaches from four countries (England, France, Spain, and Greece) were randomly assigned to either the intervention or control group. Coaches' behaviors were assessed at three time points during the season using a validated observational system based on motivational theories. RESULTS: A series of linear and quadratic multilevel models revealed that, compared to the control group, intervention coaches demonstrated a significant reduction in disempowering behaviors (i.e., ego-involving climate) across the season and a temporary increase (assessed 1 month post-intervention) in features of an empowering climate (i.e., autonomy support and relatedness support). CONCLUSION: Findings highlight the training program's short- and long-term impacts and point to the need for continued support to sustain positive coaching practices and reduce the occurrence of negative coaching behaviors. CI - Copyright (c) 2026 Tzioumakis, Tessier, Smith, Fabra Lopez, Krommidas, Comoutos, Keramidas, Appleton, Sarrazin, Balaguer, Digelidis, Quested, Papaioannou and Duda. FAU - Tzioumakis, Yannis S AU - Tzioumakis YS AD - Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece. FAU - Tessier, Damien AU - Tessier D AD - SENS, Universite Grenoble Alpes, Grenoble, France. FAU - Smith, Nathan AU - Smith N AD - University of Coventry, Coventry, United Kingdom. FAU - Fabra Lopez, Priscila AU - Fabra Lopez P AD - Department of Psychology, Universidad Europea de Valencia, Valencia, Spain. FAU - Krommidas, Charalambos AU - Krommidas C AD - Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece. FAU - Comoutos, Nikos AU - Comoutos N AD - Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece. FAU - Keramidas, Panagiotis AU - Keramidas P AD - Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece. FAU - Appleton, Paul R AU - Appleton PR AD - School of Sport and Exercise Sciences, Manchester Metropolitan University, Manchester, United Kingdom. AD - Institute of Sport, Manchester Metropolitan University, Manchester, United Kingdom. FAU - Sarrazin, Philippe AU - Sarrazin P AD - SENS, Universite Grenoble Alpes, Grenoble, France. FAU - Balaguer, Isabel AU - Balaguer I AD - Department of Social Psychology, Faculty of Psychology and Speech Therapy, University of Valencia, Valencia, Spain. FAU - Digelidis, Nikos AU - Digelidis N AD - Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece. FAU - Quested, Eleanor AU - Quested E AD - Curtin University, Perth, WA, Australia. FAU - Papaioannou, Athanasios G AU - Papaioannou AG AD - Department of Physical Education and Sport Science, University of Thessaly, Trikala, Greece. FAU - Duda, Joan L AU - Duda JL AD - School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom. LA - eng PT - Journal Article DEP - 20260805 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13485734 OTO - NOTNLM OT - Achievement Goal Theory OT - coach training OT - empowering coaching OT - motivational climate OT - observation OT - self-determination theory OT - youth football COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/20 11:41 MHDA- 2026/08/20 11:42 PMCR- 2026/08/05 CRDT- 2026/08/20 06:34 PHST- 2025/01/20 00:00 [received] PHST- 2026/01/14 00:00 [revised] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/08/20 11:42 [medline] PHST- 2026/08/20 11:41 [pubmed] PHST- 2026/08/20 06:34 [entrez] PHST- 2026/08/05 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1563931 [doi] PST - epublish SO - Front Psychol. 2026 Aug 5;17:1563931. doi: 10.3389/fpsyg.2026.1563931. eCollection 2026. PMID- 42619597 OWN - NLM STAT- MEDLINE DCOM- 20260820 LR - 20260822 IS - 1460-2210 (Electronic) IS - 0141-5387 (Print) IS - 0141-5387 (Linking) VI - 48 IP - 5 DP - 2026 Aug 6 TI - Frontal sinus morphology and maturation determination. LID - 10.1093/ejo/cjag059 [doi] LID - cjag059 AB - AIM: To determine the relationship between frontal sinus morphometric measurements and established maturation indicators obtained from hand-wrist and lateral cephalometric radiographs, and to evaluate the diagnostic performance of frontal sinus morphometric measurements in discriminating growth and developmental stages. MATERIALS AND METHODS: This retrospective study analysed radiographs of 240 patients aged 9-19 years who underwent simultaneous hand-wrist and cephalometric imaging. Patients were categorized into six cervical vertebral maturation stages (CVS), with 20 females and 20 males in each stage. Hand-wrist (HWS), cervical vertebra (CVS), and dental maturation (DS) stages were assessed. Frontal sinus measurements included maximum height (FSHeight), maximum width (FSWidth), frontal sinus index (FSIndex), area (FSArea), and perimeter (FSPerimeter). Spearman's Rho assessed correlations, and ROC analysis evaluated diagnostic performance with cut-off-based accuracy rates. Reliability was examined using the Kappa coefficient, Kendall's tau-b, and intraclass correlation coefficient (ICC). RESULTS: After Benjamini-Hochberg false discovery rate (FDR) correction, no significant correlations were found between HWS or DS stages and FSHeight in male patients, or between CVS or DS stages and FSIndex. In females, FSArea showed the highest discriminatory performance for classifying the transition from pre-pubertal to pubertal stage (AUC = 0.794; P < 0.001). In males, FSWidth showed the strongest discriminatory performance (AUC = 0.817; P < 0.001). For the transition from the pubertal to post-pubertal stage, FSWidth showed the highest discriminatory performance (AUC = 0.846; P < 0.001), and all frontal sinus measurements were statistically significant in both sexes. CONCLUSION: Frontal sinus morphometry showed high reliability and meaningful associations with age and maturation indicators. However, as AUC values ranged from moderate to good (0.655-0.846) and diagnostic performance varied by sex, maturation system, and transition stage, frontal sinus morphometry should be regarded as a supplementary rather than a standalone or definitive indicator of skeletal maturation, pending longitudinal validation. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the European Orthodontic Society. FAU - Kok, Hatice AU - Kok H AUID- ORCID: 0000-0002-5874-9474 AD - Faculty of Dentistry, Department of Orthodontics, Selcuk University, Alaeddin Keykubat Campus, Akademi Square, Yeni Istanbul Street No. 309, 42150 Selcuklu, Konya, Turkiye. LA - eng PT - Journal Article PL - England TA - Eur J Orthod JT - European journal of orthodontics JID - 7909010 SB - IM MH - Humans MH - Child MH - Cephalometry/methods MH - Female MH - Retrospective Studies MH - Male MH - Adolescent MH - *Age Determination by Skeleton/methods MH - Cervical Vertebrae/growth & development/diagnostic imaging MH - *Frontal Sinus/diagnostic imaging/growth & development/anatomy & histology MH - Young Adult MH - ROC Curve MH - Reproducibility of Results MH - Wrist/diagnostic imaging MH - Sex Factors PMC - PMC13490868 OTO - NOTNLM OT - ROC curve OT - frontal sinus OT - growth and development OT - maturity OT - orthodontics COIS- Conflicts of interest: The author declares that there is no conflict of interest. EDAT- 2026/08/20 11:41 MHDA- 2026/08/20 11:42 PMCR- 2026/08/20 CRDT- 2026/08/20 05:03 PHST- 2026/08/20 11:42 [medline] PHST- 2026/08/20 11:41 [pubmed] PHST- 2026/08/20 05:03 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - 8766858 [pii] AID - cjag059 [pii] AID - 10.1093/ejo/cjag059 [doi] PST - ppublish SO - Eur J Orthod. 2026 Aug 6;48(5):cjag059. doi: 10.1093/ejo/cjag059. PMID- 42618949 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260820 LR - 20260822 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2026 Aug 6 TI - A descriptive study of patients' and families' experience of multifamily therapy for eating disorders in young adults. LID - 10.1186/s40337-026-01730-7 [doi] LID - 193 AB - BACKGROUND: Eating disorders (EDs) have profound consequences not only for affected individuals but also for their families. While multifamily therapy (MFT) is well established for children and adolescents with an ED, less is known about its relevance and impact for young adults and their families. This study aimed to explore and describe experiences and outcomes of a MFT programme for young adults with a severe ED, and their family members. METHODS: A descriptive multi-method design was used, combining qualitative and quantitative data collected at a regional specialist centre in Norway. Qualitative data consisted of group and individual interviews with young women with an ED, and family members who had participated in MFT between 2012 and 2022. Reflexive thematic analysis was applied. Quantitative data were collected from 47 young adult women and 99 family members before and after the MFT programme, using validated measures of ED psychopathology, mental health, quality of life, and family functioning. Descriptive and pre-post analyses were conducted. RESULTS: Qualitative findings generated two overarching themes: "Knowledge and tools for understanding" and "Understand and be understood". Participants described MFT as providing experiential learning, shared language, and concrete metaphors that enhanced insight into the illness and improved family communication. Quantitatively, patients reported reduced body shape concern, hostility, and trait anxiety, as well as increased satisfaction with their environment. Family members reported significantly reduced perceived burden, guilt, and need for accommodation, alongside lower levels of state anxiety following MFT. CONCLUSIONS: Findings suggest that MFT may offer meaningful benefits for both young adults with an ED and their families by strengthening understanding, communication, and emotional coping. The study extends existing evidence by highlighting the relevance of MFT beyond adolescence and underscores the importance of family-oriented interventions for young adults with a severe ED. CI - (c) 2026. The Author(s). FAU - Brinchmann, Berit Store AU - Brinchmann BS AUID- ORCID: 0000-0001-6541-4931 AD - Regional Centre for Eating Disorders, Nordland Hospital Trust, Bodo, Norway. berit.s.brinchmann@nord.no. AD - Faculty of Nursing and Health Sciences, Nord University, Postbox 1490, 8049, Bodo, Norway. berit.s.brinchmann@nord.no. FAU - Sorstrom, Anne Kristine AU - Sorstrom AK AUID- ORCID: 0000-0001-6027-3201 AD - Nordland Hospital Trust, Bodo, Norway. FAU - Jacobsen, Lisa Marie AU - Jacobsen LM AUID- ORCID: 0009-0000-5190-2475 AD - Faculty of Nursing and Health Sciences, Nord University, Levanger, Norway. FAU - Ytterstad, Gro Anita AU - Ytterstad GA AD - Regional Centre for Eating Disorders, Nordland Hospital Trust, Bodo, Norway. FAU - Trichet, Laurent Olivier AU - Trichet LO AUID- ORCID: 0009-0007-3272-8468 AD - Nordland Hospital Trust, Bodo, Norway. LA - eng PT - Journal Article DEP - 20260806 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC13487969 OAB - EDs affect not only the person who is ill but also their whole family. Many parents and siblings feel confused, worried, and unsure how to help. Multifamily therapy (MFT) brings several families together to learn, share experiences, and support each other. In this study, we explored how young adult women with an ED and their families experienced participating in a MFT programme in Norway. We combined interviews with patients and family members, and questionnaires completed before and after the programme. Participants described MFT as helpful because it gave them new ways to understand the illness and talk about difficult topics. Creative exercises and shared discussions helped families see the ED as something separate from the person and facilitated communication and mutual understanding. The questionnaires showed that patients felt less anxious and less unhappy with their body shape, while family members felt less guilt, stress, and need to adapt their lives around the illness. Overall, the findings suggest that MFT can be a valuable form of support for young adults with an ED and their families, helping them feel less alone and better equipped to cope together. OABL- eng OTO - NOTNLM OT - Adults OT - Descriptive OT - Eating disorder OT - Multifamily therapy COIS- Declarations. Ethics approval and consent to participate: The study was approved by a Regional Committee for Medical and Health Research Ethics (No. 2014/1621/No. 655808). Each participant received oral and written information about the study and signed a consent form. They were also informed that they could withdraw from the study at any time. The data were treated confidentially and anonymised. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/08/20 05:43 MHDA- 2026/08/20 05:44 PMCR- 2026/08/06 CRDT- 2026/08/20 00:31 PHST- 2026/01/30 00:00 [received] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/20 05:44 [medline] PHST- 2026/08/20 05:43 [pubmed] PHST- 2026/08/20 00:31 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 10.1186/s40337-026-01730-7 [pii] AID - 1730 [pii] AID - 10.1186/s40337-026-01730-7 [doi] PST - epublish SO - J Eat Disord. 2026 Aug 6;14(1):193. doi: 10.1186/s40337-026-01730-7. PMID- 42618859 OWN - NLM STAT- MEDLINE DCOM- 20260820 LR - 20261008 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 9 DP - 2026 Aug 19 TI - Bioelectrical impedance analysis versus dual-energy X-ray absorptiometry for body composition assessment in children with chronic kidney disease. LID - 679 [pii] LID - 10.1007/s00431-026-07355-x [doi] AB - INTRODUCTION: Children with chronic kidney disease (CKD) exhibit progressive body composition alterations. While dual-energy X-ray absorptiometry (DXA) is the reference standard, its routine use is limited by cost, radiation, and availability. Bioelectrical impedance analysis (BIA) offers a portable, radiation-free alternative, but its accuracy relative to DXA in paediatric CKD remains insufficiently evaluated. METHODS: This cross-sectional study enrolled 102 children aged 5-14 years with CKD stages 3-5. Same-day BIA and DXA measurements were performed. Agreement between methods was assessed using Pearson's correlation coefficient, Lin's concordance correlation coefficient (CCC), and Bland-Altman analysis. Associations with CKD stage and sex were examined. RESULTS: BIA showed strong to very strong correlations with DXA for fat mass (FM; r = 0.93), fat-free mass (FFM; r = 0.91), and total bone mineral content (BMC; r = 0.84). Lin's CCC indicated poor concordance for all parameters (all < 0.90): FFM 0.87, total BMC 0.81, total bone mineral density (BMD) 0.74, FM 0.66 and body fat percentage (BF%) 0.29. BIA systematically underestimated FM and overestimated FFM relative to DXA. DXA detected significant stage-wise reductions in FM, FMI, FFM and FFMI across CKD stages, whereas BIA detected only the decline in FFMI (p = 0.012). CONCLUSIONS: Despite strong correlations, BIA showed poor concordance with DXA for every parameter assessed, with clinically unacceptable limits of agreement; correlation does not imply interchangeability. BIA may retain a role in population-level nutritional screening in resource-limited settings, although its ability to track change was not tested here; DXA remains necessary for individual-level assessment in paediatric CKD. What is known * Children with CKD experience progressive lean tissue loss, fat redistribution, and impaired bone mineralisation contributing to growth failure. * DXA is the reference standard for body composition assessment, but it is limited by cost, radiation, and availability. What is new * BIA shows a strong to very strong correlation with DXA but poor concordance (Lin's CCC < 0.90) for every body composition and bone parameter in paediatric CKD stages 3-5. * BIA cannot detect stage-wise differences in body composition that DXA identifies, limiting its diagnostic precision in this population. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Karri, Madhu Sudhan AU - Karri MS AD - Department of Paediatrics, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. FAU - Dawman, Lesa AU - Dawman L AD - Department of Paediatrics, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. lesadawman@gmail.com. FAU - Sadasivam, Deepthika AU - Sadasivam D AD - Department of Paediatrics, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. FAU - Vallabhaneni, Pujitha AU - Vallabhaneni P AD - Department of Paediatrics, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. FAU - Mahajan, Shailza AU - Mahajan S AD - Department of Paediatrics, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. FAU - Singh, Tulika AU - Singh T AD - Department of Radiodiagnosis, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. FAU - Kaur, Harvinder AU - Kaur H AD - Department of Paediatrics, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. FAU - Yadav, Jaivinder AU - Yadav J AD - Department of Paediatrics, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. FAU - Tiewsoh, Karalanglin AU - Tiewsoh K AD - Department of Paediatrics, Advanced Paediatrics Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260819 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Child MH - *Absorptiometry, Photon/methods MH - Female MH - Male MH - Cross-Sectional Studies MH - *Electric Impedance MH - Adolescent MH - *Body Composition MH - *Renal Insufficiency, Chronic/physiopathology MH - Child, Preschool MH - Bone Density MH - Reproducibility of Results OTO - NOTNLM OT - Bioelectrical impedance analysis OT - Body composition OT - Bone mineral density OT - Children OT - Chronic kidney disease OT - Dual-energy X-ray absorptiometry COIS- Declarations. Ethical approval: All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee at which the study was conducted (Institutional Ethics Committee, Post Graduate Institute of Medical Education and Research, Chandigarh, India, IEC approval number: No.IEC-INT/2024/MD-1684, dated: 16.03.2024) and the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent: Written informed consent was obtained from all parents or legal guardians prior to enrolment. Conflicts of interest: None of the authors has any disclosures or conflicts of interest concerning this article's research, authorship, or publication. EDAT- 2026/08/20 05:43 MHDA- 2026/08/20 05:44 CRDT- 2026/08/20 00:15 PHST- 2026/06/09 00:00 [received] PHST- 2026/08/16 00:00 [accepted] PHST- 2026/07/24 00:00 [revised] PHST- 2026/08/20 05:44 [medline] PHST- 2026/08/20 05:43 [pubmed] PHST- 2026/08/20 00:15 [entrez] AID - 10.1007/s00431-026-07355-x [pii] AID - 10.1007/s00431-026-07355-x [doi] PST - epublish SO - Eur J Pediatr. 2026 Aug 19;185(9):679. doi: 10.1007/s00431-026-07355-x. PMID- 42617192 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260822 IS - 1598-6357 (Electronic) IS - 1011-8934 (Print) IS - 1011-8934 (Linking) VI - 41 IP - 32 DP - 2026 Aug 17 TI - Twin Birth Weight Chart Comparisons in Korea. PG - e215 LID - 10.3346/jkms.2026.41.e215 [doi] LID - e215 AB - BACKGROUND: Birth weight deviations from gestational age-specific standards affect neonatal outcomes. While singleton references are established, their applicability to twins is debated. With the increasing incidence of twin and preterm births, twin-specific growth standards remain limited in Korea. This study systematically analyzed twin growth trajectories, considering sex, mode of conception, and chorionicity, to establish accurate references. METHODS: This study analyzed data from the Korean Neonatal Network (2013-2020; 60 years). T-scores for RF parameters were derived from a young reference subgroup aged 18-45 years (n = 1001). Associations with sex, age, body mass index and physical activity were analysed. RESULTS: All NU parameters differed significantly by sex (all p < 0.001). Median RF-CSA was 4.60 cm(2) (IQR 3.83-5.58) in women and 6.77 cm(2) (5.55-7.91) in men; median RF-Y axis at rest was 1.56 cm (1.33-1.80) and 1.91 cm (1.65-2.17), and during contraction 1.97 cm (1.71-2.24) and 2.47 cm (2.15-2.78), respectively. Median total abdominal subcutaneous adipose tissue (T-SAT) was 1.77 cm (1.16-2.39) in women and 1.65 cm (1.13-2.22) in men. RF measurements correlated moderately-strongly with BIA-derived muscle mass (r = 0.45-0.65) and HGS (r = 0.49-0.58). T-SAT correlated with BIA fat mass and waist circumference (r = 0.45-0.65), whereas visceral adipose tissue showed weaker associations (r approximately 0.33). RF-CSA and RF-Y axis increased across physical-activity categories (p < 0.05). Absolute RF values did not differ by BMI; however, when indexed to body weight, participants with BMI > 25 kg/m(2) had lower RF-CSA and RF-Y values (all p < 0.001). RF parameters followed a normal distribution, whereas adipose tissue measures did not. In the young reference group (18-45 years), mean +/- SD RF-Y axis was 1.68 +/- 0.33 cm in women and 2.05 +/- 0.37 cm in men. When applying T-score criteria, the -2 standard deviation cut-off identified 1.4%-11.7% of adults aged >/=45 years as having low muscle mass. CONCLUSIONS: This study provides the first age- and sex-specific population-based reference values for nutritional ultrasound measurements in an apparently healthy adult Spanish population. These findings support the validity, clinical applicability, and standardisation of nutritional ultrasound for the assessment of muscle mass, with potential utility in the diagnosis of sarcopenia and malnutrition. CI - (c) 2026 The Author(s). Journal of Cachexia, Sarcopenia and Muscle published by Wiley Periodicals LLC. FAU - Moreno-Torres-Taboada, Carolina AU - Moreno-Torres-Taboada C AUID- ORCID: 0009-0002-2768-8151 AD - Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Malaga, Spain. AD - Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, Malaga, Spain. FAU - Romero-Marquez, Jose M AU - Romero-Marquez JM AD - Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, Spain. AD - Foundation for Biosanitary Research of Eastern Andalusia - Alejandro Otero (FIBAO), Granada, Spain. AD - Faculty of Health Sciences. Department of Nutrition and Sports Sciences, International University of La Rioja, Logrono, Spain. FAU - Garcia-Olivares, Maria AU - Garcia-Olivares M AD - Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Malaga, Spain. AD - Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, Malaga, Spain. AD - IBIMA BIONAND Platform, Biomedical Research Institute of Malaga, Malaga, Spain. AD - Department of Endocrinology and Nutrition, QuironSalud Malaga Hospital, Malaga, Spain. FAU - Novo-Rodriguez, Maria AU - Novo-Rodriguez M AD - Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, Spain. AD - Foundation for Biosanitary Research of Eastern Andalusia - Alejandro Otero (FIBAO), Granada, Spain. FAU - Fernandez-Jimenez, Rocio AU - Fernandez-Jimenez R AD - Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, Malaga, Spain. AD - IBIMA BIONAND Platform, Biomedical Research Institute of Malaga, Malaga, Spain. AD - Department of Endocrinology and Nutrition, QuironSalud Malaga Hospital, Malaga, Spain. AD - Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Malaga, Spain. FAU - Vegas-Aguilar, Isabel AU - Vegas-Aguilar I AD - IBIMA BIONAND Platform, Biomedical Research Institute of Malaga, Malaga, Spain. AD - Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Malaga, Spain. FAU - Garcia-Luna, Pedro Pablo AU - Garcia-Luna PP AD - Nutrition Unit, Endocrinology and Nutrition Department, Virgen del Rocio University Hospital, Sevilla, Spain. FAU - Garcia-Rey, Silvia AU - Garcia-Rey S AD - Nutrition Unit, Endocrinology and Nutrition Department, Virgen del Rocio University Hospital, Sevilla, Spain. FAU - Garcia-Almeida, Jose Manuel AU - Garcia-Almeida JM AD - Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, Malaga, Spain. AD - IBIMA BIONAND Platform, Biomedical Research Institute of Malaga, Malaga, Spain. AD - Department of Endocrinology and Nutrition, QuironSalud Malaga Hospital, Malaga, Spain. AD - Department of Endocrinology and Nutrition, Virgen de la Victoria University Hospital, Malaga, Spain. AD - Network Biomedical Research Center Physiopathology of Obesity and Nutrition (CiberOBN), Carlos III Health Institute, Madrid, Spain. FAU - Olveira, Gabriel AU - Olveira G AD - Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Malaga, Spain. AD - Department of Medicine and Dermatology, Faculty of Medicine, University of Malaga, Malaga, Spain. AD - IBIMA BIONAND Platform, Biomedical Research Institute of Malaga, Malaga, Spain. AD - Biomedical Research Networking Center in Diabetes and Associated Metabolic Disorders (CIBERDEM), Instituto de Salud Carlos III, Malaga, Spain. CN - VALORES Group LA - eng GR - C24051/Fresenius Kabi/ PT - Journal Article PT - Multicenter Study PL - Germany TA - J Cachexia Sarcopenia Muscle JT - Journal of cachexia, sarcopenia and muscle JID - 101552883 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Middle Aged MH - Reference Values MH - Aged MH - Ultrasonography/methods MH - Adolescent MH - Aged, 80 and over MH - Young Adult MH - Cross-Sectional Studies MH - Body Composition MH - *Muscle, Skeletal/diagnostic imaging/physiology MH - Adipose Tissue/diagnostic imaging PMC - PMC13487697 OTO - NOTNLM OT - body composition OT - malnutrition OT - muscle ultrasound OT - nutritional ultrasound OT - reference values OT - sarcopenia COIS- The authors declare no conflicts of interest. FIR - The Valores Group, For IR - The Valores Group F FIR - Lopez-de-la-Torre-Casares, Martin IR - Lopez-de-la-Torre-Casares M IRAD- Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, Spain. FIR - Munoz-Garach, Araceli IR - Munoz-Garach A IRAD- Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, Spain. FIR - Novo-Rodriguez, Cristina IR - Novo-Rodriguez C IRAD- Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, Spain. FIR - Guardia-Baena, Juan Manuel IR - Guardia-Baena JM IRAD- Department of Endocrinology and Nutrition, Virgen de las Nieves University Hospital, Granada, Spain. FIR - Padial-Barranco, Marina IR - Padial-Barranco M IRAD- Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Malaga, Spain. FIR - Porras-Perez, Nuria IR - Porras-Perez N IRAD- Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Malaga, Spain. FIR - Rojo-Martinez, Gemma IR - Rojo-Martinez G IRAD- Department of Endocrinology and Nutrition, Regional University Hospital of Malaga, Malaga, Spain. FIR - Del Carmen Roque-Cuellar, Maria IR - Del Carmen Roque-Cuellar M IRAD- Nutrition Unit, Endocrinology and Nutrition Department, Virgen del Rocio University Hospital, Sevilla, Spain. FIR - Jimenez-Sanchez, Andres IR - Jimenez-Sanchez A IRAD- Nutrition Unit, Endocrinology and Nutrition Department, Virgen del Rocio University Hospital, Sevilla, Spain. FIR - Martinez-Ortega, Antonio Jesus IR - Martinez-Ortega AJ IRAD- Nutrition Unit, Endocrinology and Nutrition Department, Virgen del Rocio University Hospital, Sevilla, Spain. EDAT- 2026/08/19 14:49 MHDA- 2026/08/19 14:50 PMCR- 2026/08/19 CRDT- 2026/08/19 06:13 PHST- 2026/06/18 00:00 [revised] PHST- 2026/02/18 00:00 [received] PHST- 2026/06/25 00:00 [accepted] PHST- 2026/08/19 14:50 [medline] PHST- 2026/08/19 14:49 [pubmed] PHST- 2026/08/19 06:13 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - JCSM70344 [pii] AID - 10.1002/jcsm.70344 [doi] PST - ppublish SO - J Cachexia Sarcopenia Muscle. 2026 Aug;17(4):e70344. doi: 10.1002/jcsm.70344. PMID- 42614440 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260820 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - A community-based educational initiative to support awareness of relative energy deficiency in sport among adolescent athletes. PG - 1868398 LID - 10.3389/fpubh.2026.1868398 [doi] LID - 1868398 AB - Relative Energy Deficiency in Sport (REDs) is a syndrome caused by chronic low energy availability (LEA) and can disrupt hormonal, metabolic and psychological functioning. Adolescents are particularly vulnerable because they are still growing, have high energy requirements and are susceptible to sociocultural pressures. Despite increasing scientific attention, awareness and prevention of REDs remain insufficient in everyday sport settings. This community case study describes the Energy for Long-Term Health initiative, implemented in 2025-2026 in the Czech Republic across six sports-focused secondary schools ( approximately 300 students, aged 15-19 years). Each school received an interactive workshop (60-120 min) structured into four blocks: (1) explanation of energy availability and its practical implications; (2) consequences of LEA for health and performance; (3) recognition of warning signs and risk situations; and (4) preventive strategies and the role of the support team. Secondary target groups included coaches, teachers and parents, who were engaged through reusable visual materials and online dissemination via the online platform. Key lessons were that adolescent REDs education requires age-appropriate language, opportunities for anonymous questions and careful facilitation of sensitive topics. Combining face-to-face workshops with online resources extended reach and reinforced key messages. Although no formal evaluation of effectiveness was conducted, high attendance and positive informal feedback suggest that university-supported community initiatives can enhance awareness of REDs among young athletes and their support networks. Future applications should incorporate formal needs assessments, systematic evaluation, and validated measures of knowledge and behaviour change. CI - Copyright (c) 2026 Cizlerova and Hlinsky. FAU - Cizlerova, Nikola AU - Cizlerova N AD - Faculty of Sports Studies, Masaryk University, Brno, Czechia. FAU - Hlinsky, Tomas AU - Hlinsky T AD - Faculty of Sports Studies, Masaryk University, Brno, Czechia. LA - eng PT - Journal Article DEP - 20260804 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - *Athletes/education MH - *Relative Energy Deficiency in Sport/prevention & control MH - Czech Republic MH - Female MH - *Health Education/methods MH - Sports PMC - PMC13481860 OTO - NOTNLM OT - adolescent athletes OT - community education OT - low energy availability OT - prevention OT - sports nutrition COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/19 14:49 MHDA- 2026/08/19 14:50 PMCR- 2026/08/04 CRDT- 2026/08/19 05:16 PHST- 2026/04/29 00:00 [received] PHST- 2026/07/07 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/08/19 14:50 [medline] PHST- 2026/08/19 14:49 [pubmed] PHST- 2026/08/19 05:16 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1868398 [doi] PST - epublish SO - Front Public Health. 2026 Aug 4;14:1868398. doi: 10.3389/fpubh.2026.1868398. eCollection 2026. PMID- 42614353 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260819 LR - 20260820 IS - 2673-3153 (Electronic) IS - 2673-3153 (Print) IS - 2673-3153 (Linking) VI - 8 DP - 2026 TI - The value of anti-Mullerian hormone for diagnosing polycystic ovary syndrome in adolescents: a case-control study based on an epidemiological survey. PG - 1907699 LID - 10.3389/frph.2026.1907699 [doi] LID - 1907699 AB - BACKGROUND: Updated 2023 international evidence-based guidelines do not recommend anti-Mullerian hormone (AMH) for diagnosing adolescent polycystic ovary syndrome (PCOS, also newly termed polyendocrine metabolic ovarian syndrome [PMOS]) due to limited specificity. Physiological multifollicular ovaries are prevalent in teenagers, and existing studies show massive heterogeneity in participant age, BMI, AMH detection platforms and cut-off thresholds without unified adolescent-specific standards. This study aimed to analyze serum AMH correlations with core adolescent PCOS phenotypes and evaluate the auxiliary diagnostic performance of AMH for adolescent PCOS. METHODS: Based on a cross-sectional school-based epidemiological survey among adolescent girls aged 14-18 years, we enrolled 211 healthy girls, 158 girls with oligo-/amenorrhea, 38 girls with isolated clinical hirsutism, 51 girls with isolated biochemical hyperandrogenemia, and 39 adolescent PCOS patients for case-control analysis. Pearson's correlation coefficients were calculated to determine the correlations between AMH and various parameters. Receiver Operating Characteristic (ROC) curve analysis was performed to examine the diagnostic performance of AMH. RESULTS: Serum AMH concentrations were significantly higher in girls with oligo-/amenorrhea and isolated biochemical hyperandrogenemia relative to healthy controls (P < 0.05), while isolated hirsutism presented comparable AMH levels with controls (P > 0.05). Adolescent PCOS patients had the highest AMH levels among all subgroups (P < 0.05). AMH was positively correlated with all circulating androgen markers (T, FAI, A2, fT, DHEAS) but showed no correlation with age, menarcheal age, gynecological age, BMI, WHR or SHBG. Within the PCOS cohort, only serum testosterone maintained an independent positive correlation with AMH (r = 0.450, P = 0.004). ROC analysis showed an AUC of AMH for adolescent PCOS of 0.717 (95%CI: 0.625-0.809, P < 0.001). Bootstrap-validated optimal AMH cut-off value was 4.0 ng/mL, with sensitivity 51.3% (95CI: 35.4%-67.2%) and specificity 86.1% (95CI: 81.2%-90.0%). post-hoc power analysis demonstrated moderate statistical power of 0.74 for this ROC model due to limited PCOS sample size (n = 39). CONCLUSIONS: Serum AMH is closely correlated with two core diagnostic manifestations of adolescent PCOS: ovulatory dysfunction and biochemical hyperandrogenemia. Nevertheless, the low sensitivity of the 4.0 ng/mL threshold leads to nearly half missed PCOS cases if used alone for screening. Combined with inherent incorporation bias, absence of ovarian ultrasound data and consistent 2023 guideline recommendations, AMH can only serve as an adjunctive auxiliary biomarker rather than an independent diagnostic or screening tool for adolescent PCOS. Multicenter studies with standardized ovarian ultrasonography and external validation cohorts are required to establish generalizable age-specific AMH cut-offs for adolescents. CI - (c) 2026 Hong, Li, Yang, Zhou and Dong. FAU - Hong, Yu AU - Hong Y AD - Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, Guangzhou, China. AD - Department of Obstetrics and Gynecology, Kiangwu Hospital, Macao SAR, China. FAU - Li, Enping AU - Li E AD - Department of Obstetrics and Gynecology, Kiangwu Hospital, Macao SAR, China. FAU - Yang, Dongzi AU - Yang D AD - Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, Guangzhou, China. FAU - Zhou, Zehong AU - Zhou Z AD - Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, Guangzhou, China. FAU - Dong, Zhe AU - Dong Z AD - Department of Obstetrics and Gynecology, Memorial Hospital of Sun Yat-Sen University, Guangzhou, China. LA - eng PT - Journal Article DEP - 20260804 PL - Switzerland TA - Front Reprod Health JT - Frontiers in reproductive health JID - 9918230899006676 PMC - PMC13481504 OTO - NOTNLM OT - adolescence OT - anti-Mullerian hormone OT - auxiliary diagnostic biomarker OT - polycystic ovary syndrome OT - polyendocrine metabolic ovarian syndrome COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/19 14:49 MHDA- 2026/08/19 14:50 PMCR- 2026/08/04 CRDT- 2026/08/19 05:07 PHST- 2026/06/15 00:00 [received] PHST- 2026/07/09 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/08/19 14:50 [medline] PHST- 2026/08/19 14:49 [pubmed] PHST- 2026/08/19 05:07 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - 10.3389/frph.2026.1907699 [doi] PST - epublish SO - Front Reprod Health. 2026 Aug 4;8:1907699. doi: 10.3389/frph.2026.1907699. eCollection 2026. PMID- 42614308 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260819 LR - 20260820 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Gut microbiota of sprint athletes: signature microbes and dietary links. PG - 1855417 LID - 10.3389/fnut.2026.1855417 [doi] LID - 1855417 AB - BACKGROUND: The gut microbiota has emerged as an important biological factor associated with host physiological status in athletes. However, relevant research remains limited for sprint athletes, whose physiological demands differ substantially from those of endurance athletes. OBJECTIVE: This study aimed to characterize the gut microbiota profile of college sprint athletes, compare it with non-athletic peers, identify potential sprint-associated bacterial taxa, and explore diet-microbiota associations to propose potential nutritional hypotheses for these signature taxa. METHODS: Fecal samples were collected from 20 college sprint athletes and 23 non-athletic college students for metagenomic sequencing. Dietary intake was assessed using a validated food frequency questionnaire. Alpha and beta diversity analyses were performed to evaluate microbial community diversity and structure. LEfSe was used to identify differentially abundant taxa. Functional annotation and enrichment were conducted using KEGG, GO, and other databases. Spearman's correlation was applied to examine diet-microbiota relationships. RESULTS: Alpha diversity indices (Shannon, Chao1, etc.) did not differ significantly between groups. In contrast, beta diversity analysis revealed significant structural separation. LEfSe identified Segatella copri (LDA = 4.986, p = 0.017) and Bifidobacterium adolescentis (LDA = 3.154, p = 0.003) as signature taxa in athletes, both with significantly higher abundance than in non-athletes. Functional analysis showed predicted enrichment of pathways related to energy metabolism (carbohydrate metabolism, ATP binding) and amino acid metabolism in athletes. Correlation analysis indicated that S. copri abundance was nominally positively associated with dairy intake (r = 0.31, p = 0.045), while B. adolescentis was nominally associated with whole grains, soy milk/soy powder, and dairy products. CONCLUSION: College sprint athletes possess a distinct gut microbiota structure compared with non-athletes. S. copri and B. adolescentis represent distinct microbial signatures associated with sprint athletes, accompanied by corresponding predicted functional pathway enrichment. Specific dietary patterns, including the intake of whole grains, soy milk/soy powder, and dairy products, exhibit exploratory nominal associations with the signature gut microbiota composition of sprinters. CI - Copyright (c) 2026 Su, Lan, Chen and Wang. FAU - Su, Chuanjian AU - Su C AD - Clinical Medical College of Anhui Medical University, Anhui Medical University, Hefei, Anhui, China. FAU - Lan, Jinfeng AU - Lan J AD - Army Arms University of PLA, Hefei, Anhui, China. FAU - Chen, Huimin AU - Chen H AD - The First Affiliated Hospital of Anhui Medical University, Anhui Medical University, Hefei, Anhui, China. FAU - Wang, Daoming AU - Wang D AD - School of Physical Education and Health, Anhui Medical University, Hefei, Anhui, China. LA - eng PT - Journal Article DEP - 20260804 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13481514 OTO - NOTNLM OT - college students OT - diet-microbiota interaction OT - gut microbiota OT - metagenomic sequencing OT - sprint athletes OT - sprint-associated bacteria COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/19 14:49 MHDA- 2026/08/19 14:50 PMCR- 2026/08/04 CRDT- 2026/08/19 05:00 PHST- 2026/04/14 00:00 [received] PHST- 2026/07/03 00:00 [revised] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/08/19 14:50 [medline] PHST- 2026/08/19 14:49 [pubmed] PHST- 2026/08/19 05:00 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - 10.3389/fnut.2026.1855417 [doi] PST - epublish SO - Front Nutr. 2026 Aug 4;13:1855417. doi: 10.3389/fnut.2026.1855417. eCollection 2026. PMID- 42613030 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260926 IS - 1464-3685 (Electronic) IS - 0300-5771 (Print) IS - 0300-5771 (Linking) VI - 55 IP - 5 DP - 2026 Aug 18 TI - Elucidating the proteomic pathways linking childhood body mass index with type 2 diabetes: a Mendelian randomization and recall-by-genotype study. LID - 10.1093/ije/dyag165 [doi] LID - dyag165 AB - BACKGROUND: Increased childhood adiposity contributes to higher type 2 diabetes (T2D) risk, but the underlying mechanisms remain unclear. Furthermore, whether these mechanistic pathways are shared across ethnic groups has not been explored. METHODS: We conducted a two-step Mendelian randomization (MR) using European-based summary statistics from genome-wide association studies of childhood body mass index (BMI) (n = 61 111), adulthood proteomics (n = 35 559), and later life T2D (cases: 242 283; controls: 1 569 734). We also conducted a recall-by-genotype (RbG) study in a Chinese birth cohort (n = 250) to assess whether childhood BMI was associated with the identified proteomic signals in an East Asian population. Analyses included multi-instrument MR methods (inverse variance weighted and MR-Egger) and, for single-instrument proteins, cis-MR using the Wald ratio, with colocalization validation. Multiple testing was adjusted using false discovery rate (FDR). RESULTS: Higher genetically predicted childhood BMI was associated with 1299 proteins (FDR-adjusted P < .05), of which 36 proteins were associated with higher T2D risk. Six proteins were supported by colocalization (PPH4 > 80%). Genetically predicted higher childhood BMI was positively associated with GCKR, RBP1, ENTPD6, and GST A1-1, and inversely associated with PRSS27 and SHBG. The proportion of the BMI-T2D effect mediated by these proteins ranged from 1.87% to 12.92%. However, only SHBG was replicated in Asians in the RbG study. CONCLUSIONS: Our study identified putative actionable proteins that could reduce the elevated T2D risk attributable to childhood adiposity in Europeans, but their relevance in Asian populations requires further investigation. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the International Epidemiological Association. FAU - Chen, Siyu AU - Chen S AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Liang, Yiwen AU - Liang Y AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Luo, Shan AU - Luo S AUID- ORCID: 0000-0003-3368-9935 AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. AD - Department of Family Medicine and Primary Care, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Zheng, Jie AU - Zheng J AUID- ORCID: 0000-0002-4265-6695 AD - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Yoshiji, Satoshi AU - Yoshiji S AD - Department of Human Genetics, McGill University, Montreal, QC, Canada. FAU - Power, Grace M AU - Power GM AUID- ORCID: 0000-0002-5702-7728 AD - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom. AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom. AD - Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia. FAU - Xu, Zikun AU - Xu Z AD - Department of Electrical and Electronic Engineering, Imperial College London, London, United Kingdom. FAU - Burgess, Stephen AU - Burgess S AUID- ORCID: 0000-0001-5365-8760 AD - MRC Biostatistics Unit, Cambridge Institute of Public Health, University of Cambridge, Cambridge, United Kingdom. FAU - Cowling, Benjamin John AU - Cowling BJ AUID- ORCID: 0000-0002-6297-7154 AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Lam, Hugh Simon AU - Lam HS AD - Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Li, Albert Martin AU - Li AM AD - Department of Paediatrics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Leung, Gabriel Matthew AU - Leung GM AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. FAU - Schooling, Catherine Mary AU - Schooling CM AUID- ORCID: 0000-0001-9933-5887 AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. AD - Graduate School of Public Health and Health Policy, City University of New York, New York, NY, United States. FAU - Au Yeung, Shiu Lun AU - Au Yeung SL AUID- ORCID: 0000-0001-6136-1836 AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong Special Administrative Region, China. LA - eng GR - 216106/Health Care and Promotion Fund, Health and Welfare Bureau, Government of the Hong Kong SAR/ GR - 03040771/Health and Health Services Research Fund/ GR - 05060671/Health and Health Services Research Fund/ GR - 07080751/Health and Health Services Research Fund/ GR - 07080841/Health and Health Services Research Fund/ PT - Journal Article PL - England TA - Int J Epidemiol JT - International journal of epidemiology JID - 7802871 RN - Chinese people SB - IM MH - Adult MH - Child MH - Female MH - Humans MH - Male MH - *Body Mass Index MH - *Diabetes Mellitus, Type 2/genetics/metabolism MH - Genome-Wide Association Study MH - Genotype MH - Mendelian Randomization Analysis MH - *Pediatric Obesity/genetics/metabolism MH - Polymorphism, Single Nucleotide MH - Proteomics MH - White People/genetics MH - East Asian People/genetics MH - Genetic Predisposition to Disease PMC - PMC13485351 OTO - NOTNLM OT - childhood obesity OT - proteomics OT - type 2 diabetes COIS- S.L.A.Y. received honoraria from Standard BioTools for scientific presentations on proteomic studies that was related to this study. However, Standard BioTools was not involved in the study design and data analysis of this study. S.B. and C.M.S. serve as editors of the International Journal of Epidemiology, but were not involved in the review, editorial assessment, or decision to publish this manuscript. Other authors declared no conflict of interest. EDAT- 2026/08/18 23:36 MHDA- 2026/08/18 23:37 PMCR- 2026/08/18 CRDT- 2026/08/18 20:03 PHST- 2025/11/02 00:00 [received] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/08/18 23:37 [medline] PHST- 2026/08/18 23:36 [pubmed] PHST- 2026/08/18 20:03 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - 8764056 [pii] AID - dyag165 [pii] AID - 10.1093/ije/dyag165 [doi] PST - ppublish SO - Int J Epidemiol. 2026 Aug 18;55(5):dyag165. doi: 10.1093/ije/dyag165. PMID- 42612614 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260909 IS - 2352-3964 (Electronic) IS - 2352-3964 (Linking) VI - 131 DP - 2026 Sep TI - Trans-omics integration underscores distinct roles of polyunsaturated phospholipids in bidirectional offspring birth weight deviations. PG - 106435 LID - S2352-3964(26)00319-1 [pii] LID - 10.1016/j.ebiom.2026.106435 [doi] LID - 106435 AB - BACKGROUND: Abnormal birth weights are associated with adverse pregnancy outcomes and future metabolic consequences. We aimed to examine cord blood lipidomes from low, normal and high birth weight (LBW, NBW, HBW) infants to identify core lipid signatures associated with non-optimum birth weight, and to derive biological insights through trans-omics data integration with placental proteome, maternal plasma lipidome and clinical phenome. METHODS: We conducted quantitative lipidomics of cord blood samples from two independent cohorts: a retrospective discovery cohort (n = 147) and a prospective validation cohort (n = 73). Integration with placental proteomics, maternal plasma lipidomics and clinical phenomics was conducted to elucidate potential biological implications. FINDINGS: We identified substantial reductions in cord blood polyunsaturated phospholipids (PUFA-PLs) (FDR <0.05) associated with placental vesicle trafficking and formation in LBW, and altered neutrophil degranulation in HBW. Combinatorial analyses of paired maternal plasma and cord blood samples indicated that cord blood PUFA-PL reductions were not attributable to deficient maternal supply, but rather to impeded assimilation (LBW) and increased utilisation (HBW). INTERPRETATION: Our findings provide biological insights that may inform targetable, lipid-oriented nutritional and/or pharmacological strategies to modulate foetal growth and development, with the goal of optimising clinical outcomes for both mother and child. FUNDING: This work was supported by the National Natural Science Foundation of China (82170854, 81870579, 81870545, 82571043, 2357308); National High Level Hospital Clinical Research Funding (2022-PUMCH-C-019); Noncommunicable Chronic Diseases-National Science and Technology Major Project (2024ZD0530200 and 2024ZD0530204); Beijing Municipal Science & Technology Commission (Z201100005520011); Peking University Clinical Scientist Training Program (No. BMU2023PYJH022); Beijing Municipal Natural Science Foundation (7202163, 7184252). CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Zheng, Jia AU - Zheng J AD - Department of Endocrinology, Peking University First Hospital, Beijing, 100034, China; Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. FAU - Lam, Sin Man AU - Lam SM AD - Jiangsu Key Laboratory of Molecular Targets and Intervention for Metabolic Diseases, LipidALL Technologies, Changzhou, 213022, China; Guangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, 510095, China. FAU - Florence Lim, Wei Ling AU - Florence Lim WL AD - Jiangsu Key Laboratory of Molecular Targets and Intervention for Metabolic Diseases, LipidALL Technologies, Changzhou, 213022, China. FAU - Zhang, Shixuan AU - Zhang S AD - Department of Endocrinology, Peking University First Hospital, Beijing, 100034, China. FAU - Mao, Lili AU - Mao L AD - Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. FAU - Zhang, Qian AU - Zhang Q AD - Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. FAU - Cui, Jingkang AU - Cui J AD - Jiangsu Key Laboratory of Molecular Targets and Intervention for Metabolic Diseases, LipidALL Technologies, Changzhou, 213022, China. FAU - Zhang, Junqing AU - Zhang J AD - Department of Endocrinology, Peking University First Hospital, Beijing, 100034, China. FAU - Gao, Ying AU - Gao Y AD - Department of Endocrinology, Peking University First Hospital, Beijing, 100034, China. FAU - Zhao, Yurong AU - Zhao Y AD - Department of Obstetrics and Gynecology, Fuxing Hospital, Capital Medical University, Beijing, 100038, China. Electronic address: zhaoyurong72@163.com. FAU - Shui, Guanghou AU - Shui G AD - State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, 100101, China; Guangzhou National Laboratory, Guangzhou, Guangdong, 510005, China. Electronic address: shui_guanghou@gzlab.ac.cn. FAU - Xiao, Xinhua AU - Xiao X AD - Key Laboratory of Endocrinology of National Health Commission, Diabetes Research Center of Chinese Academy of Medical Sciences, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. Electronic address: xiaoxh2014@vip.163.com. LA - eng PT - Journal Article DEP - 20260818 PL - Netherlands TA - EBioMedicine JT - EBioMedicine JID - 101647039 RN - 0 (Phospholipids) RN - 0 (Fatty Acids, Unsaturated) RN - 0 (Proteome) SB - IM MH - Humans MH - Female MH - *Birth Weight MH - Pregnancy MH - *Phospholipids/blood/metabolism MH - Fetal Blood/metabolism MH - Infant, Newborn MH - *Lipidomics/methods MH - Multiomics MH - *Fatty Acids, Unsaturated/blood/metabolism MH - Placenta/metabolism MH - Proteomics/methods MH - Adult MH - Proteome PMC - PMC13505370 OTO - NOTNLM OT - Abnormal birth weight OT - Cord blood lipidomics OT - PUFAs OT - Placental proteomics COIS- Declaration of interests S.M.L., W.L.F.L and J.K.C are employees of LipidALL Technologies. The other authors declare no conflicting interests. EDAT- 2026/08/18 23:36 MHDA- 2026/09/09 23:36 PMCR- 2026/08/18 CRDT- 2026/08/18 18:11 PHST- 2025/10/22 00:00 [received] PHST- 2026/07/31 00:00 [revised] PHST- 2026/08/02 00:00 [accepted] PHST- 2026/09/09 23:36 [medline] PHST- 2026/08/18 23:36 [pubmed] PHST- 2026/08/18 18:11 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - S2352-3964(26)00319-1 [pii] AID - 106435 [pii] AID - 10.1016/j.ebiom.2026.106435 [doi] PST - ppublish SO - EBioMedicine. 2026 Sep;131:106435. doi: 10.1016/j.ebiom.2026.106435. Epub 2026 Aug 18. PMID- 42612460 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260926 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 204 DP - 2026 Nov TI - Functional liver imaging score and relative enhancement index predict transplant-free survival in cirrhosis. PG - 113162 LID - S0720-048X(26)00510-3 [pii] LID - 10.1016/j.ejrad.2026.113162 [doi] AB - OBJECTIVE: To evaluate the prognostic performance of the Relative Enhancement Index (REI) and the Functional Liver Imaging Score (FLIS), derived from gadoxetic acid-enhanced MRI, for predicting transplant-free survival in patients with cirrhosis; to determine whether these imaging biomarkers provide prognostic information after adjustment for clinical severity markers; to assess their interobserver agreement; and, because transplantation and death are competing events, to disentangle the association of FLIS and REI with each outcome using a competing-risks framework. METHODS: In this retrospective study, cirrhotic patients who underwent gadoxetic acid-enhanced MRI between September 2014 and August 2018 were included and followed for up to eight years for transplant-free survival. The cohort was assembled using stratified convenience sampling, with 20 patients selected from each Child-Pugh class (A, B, and C), to ensure representation across the full spectrum of liver dysfunction. Two independent readers assessed the Relative Enhancement Index (REI) and the Functional Liver Imaging Score (FLIS). Interobserver agreement was evaluated using kappa statistics for the individual FLIS components and ICC for the total FLIS score and REI. Transplant-free survival was analyzed using Kaplan-Meier curves, the log-rank test, and Cox proportional hazards regression. Multivariable Cox regression models were constructed separately for FLIS and REI, adjusted for age, MELD score, and Child-Pugh score. A sensitivity analysis was additionally performed by treating liver transplantation as a censoring event and all-cause death as the only event of interest. In addition, a competing-risks analysis was performed using cumulative incidence functions, Gray's test, and Fine-Gray subdistribution hazard models, with death and liver transplantation analysed alternately as the event of interest. Discrimination was compared with MELD and Child-Pugh score using DeLong's test, and incremental value was assessed by the change in Harrell's C-index with likelihood-ratio testing. The proportional hazards assumption was tested with Schoenfeld residuals, and a 30-day landmark analysis was performed. RESULTS: Sixty patients were included (32 men; median age, 58 years; interquartile range [IQR], 51-64 years), with 20 patients in each Child-Pugh class by design. During follow-up, 20 patients underwent liver transplantation (33.3 %), 16 died (26.7 %), and 24 remained alive without transplantation (40 %). Interobserver agreement was excellent for both FLIS (ICC = 0.97) and REI (ICC = 0.97). Because the cohort was deliberately stratified by Child-Pugh class, absolute transplant-free survival estimates were considered cohort-specific and not interpreted as population-level survival rates. AUROC values showed moderate discrimination for the composite endpoint of death or liver transplantation (FLIS, 0.745; REI, 0.703). In univariable Cox analysis, FLIS 0-3 and REI < 100 were significant predictors of adverse outcomes (death or liver transplantation), with hazard ratios of 3.767 (95 % CI: 1.872-7.579; p < 0.001) and 3.883 (95 % CI: 1.679-8.979; p = 0.002), respectively. After adjustment for age, MELD score, and Child-Pugh score, FLIS 0-3 remained independently associated with transplant-free survival (adjusted HR, 2.64; 95 % CI: 1.10-6.34; p = 0.030), whereas the association for REI < 100 was of similar magnitude but did not reach statistical significance (adjusted HR, 2.67; 95 % CI: 0.94-7.58; p = 0.065). In the death-only sensitivity analysis, FLIS remained significantly associated with survival (log-rank p = 0.042), whereas the association for REI was attenuated and did not reach statistical significance (log-rank p = 0.096). Discrimination did not differ significantly from that of MELD (AUROC, 0.731) or Child-Pugh score (AUROC, 0.753; all DeLong p >/= 0.43), and both indices improved model fit when added to MELD (likelihood-ratio p = 0.004 for both). In competing-risks analysis, FLIS 0-3 and REI < 100 were associated with the cumulative incidence of liver transplantation (subdistribution HR, 3.42 and 6.18, respectively) but not with that of death (1.41 and 1.45). CONCLUSION: FLIS and REI demonstrate excellent interobserver agreement and are associated with transplant-free survival in patients with cirrhosis, with moderate discriminative performance by AUROC analysis. FLIS remained independently associated with outcome after adjustment for age, MELD score, and Child-Pugh score, whereas REI showed an association of similar magnitude that did not reach significance after multivariable adjustment. Competing-risks analysis indicates that the association of both indices with the composite endpoint is driven predominantly by the transplantation component, and discrimination did not differ from that of MELD or Child-Pugh score. FLIS and REI should therefore be regarded as reproducible imaging markers of progression to end-stage liver disease rather than as validated predictors of mortality. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Melo Lima, Elissandra AU - Melo Lima E AD - Department of Radiology, Federal University of Rio de Janeiro, RJ, Brazil. Electronic address: elissandra.lima@grupofleury.com.br. FAU - Eiras-Araujo, Antonio Luis AU - Eiras-Araujo AL AD - Department of Radiology, Federal University of Rio de Janeiro, RJ, Brazil; D'Or Institute for Research and Education, Rio de Janeiro, RJ, Brazil. Electronic address: antonio.eiras@rededor.com.br. FAU - Souza Rodrigues, Rosana AU - Souza Rodrigues R AD - Department of Radiology, Federal University of Rio de Janeiro, RJ, Brazil; D'Or Institute for Research and Education, Rio de Janeiro, RJ, Brazil. Electronic address: rosana.rodrigues@idor.org. FAU - Cerqueira Silva, Alexandre AU - Cerqueira Silva A AD - Surgery Department, Federal University of Rio de Janeiro, RJ, Brazil. Electronic address: acerqueira@ufrj.br. FAU - Ferreira da Motta Rezende, Guilherme AU - Ferreira da Motta Rezende G AD - Department of Hepatology, Federal University of Rio de Janeiro, RJ, Brazil. Electronic address: g.rezende@ufrj.br. FAU - Raggio Luiz, Ronir AU - Raggio Luiz R AD - Institute of Public Health, Federal University of Rio de Janeiro, RJ, Brazil. Electronic address: ronir@acd.ufrj.br. FAU - Mello Perez, Renata AU - Mello Perez R AD - Department of Radiology, Federal University of Rio de Janeiro, RJ, Brazil; D'Or Institute for Research and Education, Rio de Janeiro, RJ, Brazil. Electronic address: rmperez@hucff.ufrj.br. FAU - Braz Parente, Daniella AU - Braz Parente D AD - Department of Radiology, Federal University of Rio de Janeiro, RJ, Brazil; D'Or Institute for Research and Education, Rio de Janeiro, RJ, Brazil. Electronic address: dparente@hucff.ufrj.br. LA - eng PT - Journal Article DEP - 20260813 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 RN - K2I13DR72L (Gadolinium DTPA) RN - 0 (Contrast Media) RN - 0 (gadolinium ethoxybenzyl DTPA) SB - IM MH - Humans MH - *Liver Cirrhosis/diagnostic imaging/mortality/surgery MH - Female MH - Male MH - Gadolinium DTPA MH - Retrospective Studies MH - Contrast Media MH - *Magnetic Resonance Imaging/methods MH - *Liver Transplantation MH - Middle Aged MH - Prognosis MH - Liver/diagnostic imaging MH - Predictive Value of Tests OTO - NOTNLM OT - Biomarkers OT - Functional liver imaging score OT - Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid OT - Liver cirrhosis OT - Magnetic resonance imaging OT - Prognosis OT - Relative enhancement index OT - Survival analysis COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/18 23:36 MHDA- 2026/09/26 05:34 CRDT- 2026/08/18 18:06 PHST- 2026/04/02 00:00 [received] PHST- 2026/07/31 00:00 [revised] PHST- 2026/08/12 00:00 [accepted] PHST- 2026/09/26 05:34 [medline] PHST- 2026/08/18 23:36 [pubmed] PHST- 2026/08/18 18:06 [entrez] AID - S0720-048X(26)00510-3 [pii] AID - 10.1016/j.ejrad.2026.113162 [doi] PST - ppublish SO - Eur J Radiol. 2026 Nov;204:113162. doi: 10.1016/j.ejrad.2026.113162. Epub 2026 Aug 13. PMID- 42611885 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260820 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 8 DP - 2026 TI - Development and validation of an intelligent weight verification management system for neonatal ready-to-use parenteral nutrition infusions. PG - e0351932 LID - 10.1371/journal.pone.0351932 [doi] LID - e0351932 AB - OBJECTIVE: To develop an intelligent weight verification management system for the quality of ready-to-use neonatal parenteral nutrition (PN) infusions and validate its reliability and application efficacy, aiming to enhance the quality and safety of these infusions. METHODS: An intelligent weight verification approach was established through drug density determination, maintenance of information parameters, automatic calculation of theoretical weight by the hospital information system (HIS), and actual measurement using a high-precision electronic scale. A total of 350 bags of neonatal PN orders prepared in the Pharmacy Intravenous Admixture Services (PIVAS) of our hospital from January to June 2024 were randomly selected. Seven compounding technicians prepared 50 bags each, and two designated pharmacists conducted verification using the residual liquid method and the weighing method, respectively. The error rate between the theoretical and actual weighing values was computed, statistical analysis of the pertinent data was conducted, and the viability of the weighing method was assessed from four perspectives: precision, trend controllability, operator stability, and verification efficiency. RESULTS: The relative standard deviation (RSD) of error rates was < 1%, indicating excellent precision. The average error rate was 1.92%, with 97.43% of error rates within the predefined threshold (-1% to 5%) and 90.9% within the 3sigma range. The error rate trends for different volumes aligned with variations in filling quantities, demonstrating controllable overall error trends. The interquartile range (IQR) variation in error rates among operators at different time points was < 30%, reflecting good operational stability. The weighing method achieved significantly higher verification efficiency (15.4 minutes per bag) than the residual liquid method (28.6 minutes per bag, P < 0.05) and identified an additional 6 unqualified infusions. CONCLUSION: The weight verification system demonstrates validated reliability in improving quality assurance and operational efficiency for ready-to-use neonatal PN infusions in PIVAS settings, warranting clinical implementation. CI - Copyright: (c) 2026 Tang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Tang, Xiaolin AU - Tang X AUID- ORCID: 0000-0003-0052-5168 AD - Department of Pharmacy, Children's Hospital of Jiangxi Province, Nanchang, Jiangxi, P.R.China. FAU - Zhu, Chunhui AU - Zhu C AD - Department of Pharmacy, Children's Hospital of Jiangxi Province, Nanchang, Jiangxi, P.R.China. FAU - Cheng, Dan AU - Cheng D AD - Department of Pharmacy, Children's Hospital of Jiangxi Province, Nanchang, Jiangxi, P.R.China. FAU - Zhu, Jin AU - Zhu J AD - Department of Pharmacy, Children's Hospital of Jiangxi Province, Nanchang, Jiangxi, P.R.China. FAU - Qiu, Lijuan AU - Qiu L AD - Department of Pharmacy, Children's Hospital of Jiangxi Province, Nanchang, Jiangxi, P.R.China. FAU - Han, Xiaoxia AU - Han X AD - Department of Pharmacy, Children's Hospital of Jiangxi Province, Nanchang, Jiangxi, P.R.China. FAU - Feng, Chuanhua AU - Feng C AD - Department of Pharmacy, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, P.R.China. FAU - Chen, Mengying AU - Chen M AD - Department of Pharmacy, Children's Hospital of Jiangxi Province, Nanchang, Jiangxi, P.R.China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260818 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Parenteral Nutrition Solutions) SB - IM MH - *Parenteral Nutrition/methods MH - Humans MH - Infant, Newborn MH - Reproducibility of Results MH - *Parenteral Nutrition Solutions PMC - PMC13484958 COIS- The authors declare that they have no conflict of interest. EDAT- 2026/08/18 17:37 MHDA- 2026/08/18 17:38 PMCR- 2026/08/18 CRDT- 2026/08/18 13:34 PHST- 2026/01/21 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/08/18 17:38 [medline] PHST- 2026/08/18 17:37 [pubmed] PHST- 2026/08/18 13:34 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - PONE-D-26-03553 [pii] AID - 10.1371/journal.pone.0351932 [doi] PST - epublish SO - PLoS One. 2026 Aug 18;21(8):e0351932. doi: 10.1371/journal.pone.0351932. eCollection 2026. PMID- 42610403 OWN - NLM STAT- MEDLINE DCOM- 20261029 LR - 20261029 IS - 1724-6059 (Electronic) IS - 1121-8428 (Linking) VI - 39 IP - 8 DP - 2026 Oct 30 TI - Low agreement among the equations in healthy children and young adults. PG - 1599-1606 LID - 10.1093/joneph/aajag148 [doi] AB - BACKGROUND: Several updated equations based on creatinine and/or cystatin C have been developed to estimate glomerular filtration rate (GFR), but their concordance in adolescents and young adults remains unclear. The CKiD Under 25 years (CKiDU25) equation was developed in children and young adults with chronic kidney disease, whereas the European Kidney Function Consortium (EKFC) equation was designed for use across the lifespan. Their agreement and the factors associated with eGFR category reclassification in healthy populations remain unexplored. METHODS: We compared the CKiDU25 and EKFC equations using combined estimates, defined as the mean of creatinine- and cystatin C-based eGFR for each equation, in adolescents and young adults from the National Health and Nutrition Examination Surveys 1999-2002. Factors associated with reclassification by the EKFC equation were examined. RESULTS: The study included 4552 adolescents and young adults, representing a weighted population of approximately 57.26 million. The CKiDU25 equation showed an age-related decline in eGFR, particularly among Black males, whereas EKFC yielded more consistent eGFRs across demographic groups. Compared with CKiDU25, EKFC markedly reduced the estimated prevalence of reduced kidney function, defined as eGFR 60-89 mL/min/1.73 m2, in the healthy population (4.06% vs. 14.16%). Overall, 66.74% of participants were reclassified to a lower eGFR category by EKFC. Lower reclassification was more common among older participants, females, those without diabetes, and those with higher body mass index and waist-to-height ratio. CONCLUSIONS: Equation selection substantially affects eGFR estimation and classification in healthy adolescents and young adults, underscoring the need to consider age, sex, and race when choosing GFR estimation equations. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Societa Italiana Nefrologia/Italian Society of Nephrology; Society ownership. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Wang, Fan AU - Wang F AD - Department of Pediatrics, West China Second University Hospital, Sichuan University, Section 3, Renmin South Road, Chengdu 610041, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu 610041, China. FAU - Zhu, Yanjie AU - Zhu Y AD - Department of Pediatrics, West China Second University Hospital, Sichuan University, Section 3, Renmin South Road, Chengdu 610041, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu 610041, China. FAU - Liu, Xuwei AU - Liu X AD - Department of Pediatrics, West China Second University Hospital, Sichuan University, Section 3, Renmin South Road, Chengdu 610041, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu 610041, China. FAU - Hu, Yong AU - Hu Y AUID- ORCID: 0000-0002-3089-2113 AD - Department of Pediatrics, West China Second University Hospital, Sichuan University, Section 3, Renmin South Road, Chengdu 610041, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu 610041, China. LA - eng PT - Comparative Study PT - Journal Article PL - England TA - J Nephrol JT - Journal of nephrology JID - 9012268 RN - 0 (Cystatin C) RN - AYI8EX34EU (Creatinine) RN - 0 (Biomarkers) RN - 0 (CST3 protein, human) SB - IM MH - Humans MH - *Glomerular Filtration Rate MH - Adolescent MH - Male MH - Female MH - Young Adult MH - *Cystatin C/blood MH - *Creatinine/blood MH - Child MH - Age Factors MH - Nutrition Surveys MH - *Kidney/physiopathology MH - Biomarkers/blood MH - *Renal Insufficiency, Chronic/physiopathology/diagnosis/blood MH - Predictive Value of Tests MH - United States/epidemiology MH - Adult MH - Sex Factors OTO - NOTNLM OT - CKiD OT - EKFC OT - equation OT - glomerular filtration rate COIS- Conflicts of interest: The authors declare no competing interests. EDAT- 2026/08/18 13:56 MHDA- 2026/10/29 23:28 CRDT- 2026/08/18 06:13 PHST- 2026/05/18 00:00 [accepted] PHST- 2026/10/29 23:28 [medline] PHST- 2026/08/18 13:56 [pubmed] PHST- 2026/08/18 06:13 [entrez] AID - 8763264 [pii] AID - 10.1093/joneph/aajag148 [doi] PST - ppublish SO - J Nephrol. 2026 Oct 30;39(8):1599-1606. doi: 10.1093/joneph/aajag148. PMID- 42609271 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260818 LR - 20260819 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Nutritional and behavioral determinants of overweight and obesity among school-aged children in Shandong Province, China: evidence from a large-scale cross-sectional study. PG - 1853192 LID - 10.3389/fnut.2026.1853192 [doi] LID - 1853192 AB - BACKGROUND: Childhood overweight and obesity are pressing global health challenges with rising prevalence in China. Shandong Province, as a populous and economically developed region, provides a critical context for understanding regional patterns and determinants. METHODS: A cross-sectional survey was conducted among 83,436 children aged 9-12 years from 155 schools in 16 cities (September-November 2025). Anthropometric measurements and validated questionnaires were used to assess weight status, demographics, family environment, and lifestyle factors. Overweight/obesity was classified using International Obesity Task Force (IOTF) cut-offs. Logistic regression identified associated risk and protective factors. RESULTS: The prevalence of overweight/obesity was 19.0%. Rates were higher in boys than girls (19.9% vs. 18.2%, p < 0.001) and increased with age (11-year-olds 20.4% vs. 9-year-olds 18.0%, p < 0.001). Urban children had slightly higher prevalence than rural peers (19.6% vs. 18.7%, p = 0.002). Factors independently associated with overweight/obesity included parental overweight/obesity (OR = 1.18, 95% CI: 1.10-1.26), maternal gestational diabetes (OR = 1.53, 95% CI: 1.36-1.71), and high birth weight (OR = 1.16, 95% CI: 1.09-1.24). Lifestyle behaviors were strongly associated: <1 h/day physical activity increased risk, while >1.5 h/day was protective (OR = 0.83, 95% CI: 0.79-0.87); >8 h sleep reduced risk (OR = 0.66, 95% CI: 0.60-0.72); >3 h/day screen time (OR = 1.10, 95% CI: 1.02-1.20) and >3 h/day homework (OR = 1.49, 95% CI: 1.38-1.62) elevated risk; frequent fruit/vegetable intake was protective, whereas fast-food consumption >3 times/week increased risk (OR = 1.12, 95% CI: 1.05-1.20). CONCLUSION: Childhood overweight/obesity in Shandong Province is influenced by demographic, familial, and lifestyle factors. Findings highlight the importance of multilevel interventions-targeting family health behaviors, maternal metabolic management, school-based physical activity promotion, and community nutrition policies-to curb the rising burden of obesity. CI - Copyright (c) 2026 Wang, Yan, Xu, Pang, Li, Chen and Ge. FAU - Wang, Wance AU - Wang W AD - The School of Physical Education and Health, East China Jiaotong University, Nanchang, China. FAU - Yan, Lei AU - Yan L AD - School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China. FAU - Xu, Bowen AU - Xu B AD - The School of Physical Education and Health, East China Jiaotong University, Nanchang, China. FAU - Pang, Xiangwei AU - Pang X AD - Jafron Biomedical Co., Ltd., Jinan, China. FAU - Li, Qianqian AU - Li Q AD - Shandong University of Art and Design, Jinan, China. FAU - Chen, Ke AU - Chen K AD - The School of Physical Education and Health, East China Jiaotong University, Nanchang, China. FAU - Ge, Renkai AU - Ge R AD - The School of Physical Education and Health, East China Jiaotong University, Nanchang, China. LA - eng PT - Journal Article DEP - 20260803 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13477887 OTO - NOTNLM OT - Shandong Province OT - childhood obesity OT - lifestyle behaviors OT - overweight OT - risk factors COIS- XP was employed by Jafron Biomedical Co., Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/18 07:46 MHDA- 2026/08/18 07:47 PMCR- 2026/08/03 CRDT- 2026/08/18 04:24 PHST- 2026/04/11 00:00 [received] PHST- 2026/07/08 00:00 [revised] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/08/18 07:47 [medline] PHST- 2026/08/18 07:46 [pubmed] PHST- 2026/08/18 04:24 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.3389/fnut.2026.1853192 [doi] PST - epublish SO - Front Nutr. 2026 Aug 3;13:1853192. doi: 10.3389/fnut.2026.1853192. eCollection 2026. PMID- 42609262 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260819 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Predictors of childhood vaccination and recent influenza vaccination in older Brazilian adults: an analysis using conventional regression and machine learning approaches. PG - 1900872 LID - 10.3389/fpubh.2026.1900872 [doi] LID - 1900872 AB - BACKGROUND: Vaccination is an important public health intervention across the life course but its determinants may differ by life stage. We aimed to identify and compare predictors of childhood vaccination and recent influenza vaccination among older adults using conventional and machine learning approaches. METHODS: We used data from the second wave (2019-2021) of the Brazilian Longitudinal Study of Aging (ELSI-Brazil), a nationally representative cohort of individuals aged 50+. Analyses included 9,211 participants for childhood vaccination and 9,863 for influenza vaccination. Predictors were selected from sociodemographic, environmental, lifestyle, and health domains. Multivariable logistic regression and machine learning algorithms were used, with performance evaluated via area under the receiver operating characteristic curve (AUC). RESULTS: The best-performing machine learning model demonstrated acceptable performance for childhood vaccination (AUC = 0.72, 95% CI: 0.69-0.74) and recent influenza vaccination (AUC = 0.67, 95% CI: 0.64-0.70). For childhood vaccination, both analytical approaches identified age, sex, rural residence, parental education, school attendance at age 10, childhood access to books, and allergy as important predictors. Machine learning additionally identified age at school initiation, childhood economic status, self-rated childhood health, severe diarrhea, and history of childhood infectious diseases. Key predictors for recent influenza vaccination included age, marriage, educational level, employment, and hypertension/diabetes. Machine learning additionally highlighted the importance of vaccination history during childhood, life satisfaction, BMI, and mental health. CONCLUSION: Early-life socioeconomic and health conditions are important predictors of childhood immunization history, whereas current sociodemographic and health status are key predictors of recent vaccination. Machine learning identified supplementary predictors beyond traditional methods. CI - Copyright (c) 2026 Xu, Wang, Memon, Sun, Cheng and Long. FAU - Xu, Xianglong AU - Xu X AD - Department of Sexually Transmitted Disease, Center of Infectious Skin Diseases, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China. AD - School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, China. AD - Artificial Intelligence and Modelling in Epidemiology Program, Melbourne Sexual Health Centre, Alfred Health, Carlton, VIC, Australia. FAU - Wang, Biying AU - Wang B AD - School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Memon, Kubra Maqsood AU - Memon KM AD - School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Sun, Chen AU - Sun C AD - School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Cheng, Yang AU - Cheng Y AD - School of Public Health, Shanghai University of Traditional Chinese Medicine, Shanghai, China. FAU - Long, Fuquan AU - Long F AD - Department of Sexually Transmitted Disease, Center of Infectious Skin Diseases, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China. LA - eng PT - Journal Article DEP - 20260803 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 0 (Influenza Vaccines) SB - IM MH - Humans MH - Brazil MH - Male MH - *Influenza Vaccines/administration & dosage MH - *Machine Learning MH - Female MH - *Vaccination/statistics & numerical data MH - *Influenza, Human/prevention & control MH - Aged MH - Longitudinal Studies MH - Middle Aged MH - Predictive Learning Models MH - Prediction Algorithms MH - Socioeconomic Factors PMC - PMC13477924 OTO - NOTNLM OT - childhood OT - influenza OT - machine learning OT - older adults OT - predictors OT - recent vaccination OT - vaccination COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/18 07:46 MHDA- 2026/08/18 07:47 PMCR- 2026/08/03 CRDT- 2026/08/18 04:23 PHST- 2026/06/05 00:00 [received] PHST- 2026/07/05 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/18 07:47 [medline] PHST- 2026/08/18 07:46 [pubmed] PHST- 2026/08/18 04:23 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1900872 [doi] PST - epublish SO - Front Public Health. 2026 Aug 3;14:1900872. doi: 10.3389/fpubh.2026.1900872. eCollection 2026. PMID- 42609256 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260828 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Molecular sensitization profiles and beta-parvalbumin sensitization burden associated with clinical fish allergy in children. PG - 1918831 LID - 10.3389/fimmu.2026.1918831 [doi] LID - 1918831 AB - BACKGROUND: Fish allergy is a potentially severe condition that is frequently managed with broad elimination diets. Molecular allergology may improve risk stratification by distinguishing clinically relevant fish allergy from asymptomatic sensitization. We aimed to characterize molecular sensitization patterns in fish-sensitized children and identify molecular profiles associated with clinical fish allergy. METHODS: Sixty-one fish-sensitized children (0-18 years) were evaluated using a multiplex molecular allergy assay (ALEX2). Twenty-eight children were classified as fish-allergic based on a positive oral food challenge (OFC) or consistent clinical reactions, whereas 33 sensitized children were clinically tolerant. Molecular sensitization patterns were analyzed using Bayesian logistic model averaging (BMA), Firth penalized logistic regression, receiver operating characteristic (ROC) analysis, and hierarchical clustering. RESULTS: Sensitization to beta-parvalbumins was significantly more frequent in allergic than tolerant children. Allergic children also exhibited a substantially higher cumulative beta-parvalbumin sensitization burden (median 7 [IQR 5-7] vs 3 [IQR 1-5]; p<0.001). BMA prioritized Clu h 1, Gad m 2_3, and Cyp c 1 as the molecular allergens most strongly associated with clinical fish allergy. Sensitization to Gad m 2_3 was observed exclusively among allergic children. An exploratory parsimonious model incorporating cumulative beta-parvalbumin sensitization burden together with Gad m 2_3 achieved an optimism-corrected AUC of 0.867. CONCLUSIONS: Molecular sensitization profiles, particularly the cumulative burden of beta-parvalbumin sensitization, were associated with clinical fish allergy in children. Clu h 1 and Cyp c 1 emerged as the molecular markers most consistently associated with clinical reactivity, whereas Gad m 2_3 was observed only among allergic children in this cohort and may represent a low-prevalence exploratory finding. These findings suggest a potential role for molecular allergen profiling in risk stratification among fish-sensitized children but require validation in larger independent cohorts before clinical application. CI - Copyright (c) 2026 Dal, Heydarova and Sekerel. FAU - Dal, Sevda Tuten AU - Dal ST AD - Department of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Turkiye. FAU - Heydarova, Lala AU - Heydarova L AD - Department of Pediatrics, Azerbaijan State Advanced Training Institute for Doctors named after Aziz Aliyev, Baku, Azerbaijan. FAU - Sekerel, Bulent Enis AU - Sekerel BE AD - Department of Pediatric Allergy, Hacettepe University Faculty of Medicine, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260803 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Allergens) RN - 0 (Parvalbumins) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Humans MH - *Food Hypersensitivity/immunology/diagnosis MH - Child MH - Child, Preschool MH - Male MH - Female MH - Infant MH - *Allergens/immunology MH - Animals MH - Adolescent MH - *Fishes/immunology MH - *Parvalbumins/immunology MH - Immunoglobulin E/immunology/blood MH - Infant, Newborn MH - Immunization PMC - PMC13477939 OTO - NOTNLM OT - fish allergy OT - molecular allergology OT - pediatric allergy OT - sensitization burden OT - beta-parvalbumin COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/18 07:46 MHDA- 2026/08/18 07:47 PMCR- 2026/08/03 CRDT- 2026/08/18 04:22 PHST- 2026/06/24 00:00 [received] PHST- 2026/07/14 00:00 [revised] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/08/18 07:47 [medline] PHST- 2026/08/18 07:46 [pubmed] PHST- 2026/08/18 04:22 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1918831 [doi] PST - epublish SO - Front Immunol. 2026 Aug 3;17:1918831. doi: 10.3389/fimmu.2026.1918831. eCollection 2026. PMID- 42608744 OWN - NLM STAT- Publisher LR - 20260818 IS - 1537-7385 (Electronic) IS - 0894-9115 (Linking) DP - 2026 Aug 18 TI - Association Between Vitamin D and Muscle Mass and Function in Children and Adolescents: A Study Based on National Health and Nutrition Examination Survey (NHANES). LID - 10.1097/PHM.0000000000003130 [doi] AB - OBJECTIVE: This study aimed to investigate the association between vitamin D and muscle health in children and adolescents. DESIGN: A cross-sectional analysis was performed using data from 2,775 participants aged 8-17 years in NHANES 2011-2014. Muscle mass was evaluated through whole-body and regional muscle-to-fat ratios (MFRs), while muscle function was assessed using relative handgrip strength (RHGS). Vitamin D status was characterized by serum 25-hydroxyvitamin D (25(OH)D), 25(OH)D3, 25(OH)D2 levels, and 25(OH)D categorized as deficient, insufficient, or sufficient. The analysis employed covariate-adjusted linear regression and restricted cubic splines (RCS), with predictive ability of RHGS assessed via receiver operating characteristic (ROC) analysis. RESULTS: Significant positive associations between total 25(OH)D levels and muscle-related parameters were observed across adjusted models. Associations varied across sex and age groups, and RHGS demonstrated limited predictive value for vitamin D status across all subgroups (maximum AUC = 0.635). CONCLUSIONS: Total 25(OH)D appeared to be the most informative indicator of vitamin D status in relation to pediatric muscle health, although associations varied to sex, age, and assessment measures. RHGS demonstrated limited utility as a screening indicator for vitamin D insufficiency or deficiency status. CI - Copyright (c) 2026 Wolters Kluwer Health, LLC. All rights reserved. FAU - Tian, Feng AU - Tian F AD - Department of Pediatric Surgery, Suzhou Wujiang District Children's Hospital, Suzhou, China. FAU - Xu, Lina AU - Xu L AD - Department of Respiratory Medicine, Children's Hospital of Soochow University, China. FAU - Huang, Wei AU - Huang W AD - Department of Pediatrics, Friendship Hospital of Ily Kazak Autonomous Prefecture, China. FAU - Jiang, Dapeng AU - Jiang D AD - Department of Oncology (Ward 2), Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200100, People's Republic of China. FAU - Dai, Yinfang AU - Dai Y AD - Department of Respiratory Medicine, Children's Hospital of Soochow University, China. LA - eng PT - Journal Article DEP - 20260818 PL - United States TA - Am J Phys Med Rehabil JT - American journal of physical medicine & rehabilitation JID - 8803677 SB - IM OTO - NOTNLM OT - Children and Adolescents OT - Muscle-to-fat Ratios OT - NHANES OT - Relative Handgrip Strength OT - Vitamin D COIS- Conflict of Interest: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/18 07:46 MHDA- 2026/08/18 07:46 CRDT- 2026/08/18 00:32 PHST- 2025/06/27 00:00 [received] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/08/18 07:46 [medline] PHST- 2026/08/18 07:46 [pubmed] PHST- 2026/08/18 00:32 [entrez] AID - 00002060-990000000-01055 [pii] AID - 10.1097/PHM.0000000000003130 [doi] PST - aheadofprint SO - Am J Phys Med Rehabil. 2026 Aug 18. doi: 10.1097/PHM.0000000000003130. PMID- 42608724 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260818 LR - 20260820 IS - 2524-4434 (Electronic) IS - 2096-9384 (Print) IS - 2524-4434 (Linking) VI - 8 IP - 1 DP - 2026 Aug 18 TI - Clinical and neurophysiology study of 17 children with epileptic negative myoclonus. LID - 10.1186/s42494-026-00273-3 [doi] LID - 31 AB - BACKGROUND: Epileptic negative myoclonus (ENM) is a clinically underrecognized seizure type, and systematic data on its clinical manifestations and optimal management strategies in pediatric populations remain scarce. This case series aimed to describe the clinical manifestations, neurophysiological patterns, and therapeutic outcomes in pediatric ENM. METHODS: A retrospective descriptive analysis was conducted on 17 ENM patients diagnosed at Wuxi Children's Hospital between October 2017 and June 2024. Clinical data, electroencephalogram (EEG) findings, and treatment responses were systematically evaluated. RESULTS: The cohort showed a marked female predominance (female-to-male ratio of 12:5). All cases exhibited upper-limb ENM, with contralateral central-parietal epileptiform discharges observed in ictal EEG. Two patients presented additional lower-limb ENM accompanied by midline discharges. Clinically, ENM manifested as the initial symptom in five cases (29.4%), including two with isolated ENM. Therapeutic outcomes varied: among four non-electrical status epilepticus during sleep (ESES) patients, antiseizure medications (ASMs) achieved symptom control, including one case of oxcarbazepine (OXC)-associated ENM that resolved after transition to valproate (VPA). Of 13 ESES-positive patients, three responded to ASMs alone, while nine received methylprednisolone pulse therapy (MPT), and one surgical candidate with focal cortical dysplasia (FCD) type IIa achieved post-resection remission. Among the nine children treated with MPT: four showed a good response; four relapsed upon steroid withdrawal; and one responded well to ketogenic diet (KD) therapy. CONCLUSIONS: ENM can manifest as the initial or sole epilepsy symptom in children. The marked female predominance in this cohort suggests that sex-related factors may play an important role in the expression or underlying mechanisms of ENM. Additionally, a correlation was found between the EEG discharge patterns and the specific limb regions involved. Regarding treatment, OXC may exacerbate ENM, necessitating cautious use. Steroid therapy should be considered for ESES cases unresponsive to ASMs. Refractory ENM with ESES warrants evaluation for structural abnormalities, particularly cortical dysplasia. Early EEG and neuroimaging improve diagnostic accuracy, while combined therapies-ASMs, immunomodulation, KD, or surgery-optimize outcomes. These findings highlight ENM's diagnostic intricacy and the need for individualized management. CLINICAL TRIAL REGISTRATION: Not applicable. CI - (c) 2026. The Author(s). FAU - Zhang, Lin AU - Zhang L AD - Department of Neurology, The Affiliated Wuxi Children's Hospital of Jiangnan University, No. 299 Qingyang Road, Wuxi, Jiangsu, 214023, China. FAU - Xu, Tao AU - Xu T AD - Department of Neurology, The Affiliated Wuxi Children's Hospital of Jiangnan University, No. 299 Qingyang Road, Wuxi, Jiangsu, 214023, China. FAU - Jing, Miao AU - Jing M AD - Department of Neurology, The Affiliated Wuxi Children's Hospital of Jiangnan University, No. 299 Qingyang Road, Wuxi, Jiangsu, 214023, China. FAU - Ma, Jingbo AU - Ma J AD - Department of Neurology, The Affiliated Wuxi Children's Hospital of Jiangnan University, No. 299 Qingyang Road, Wuxi, Jiangsu, 214023, China. FAU - Sun, Mingxia AU - Sun M AD - Department of Neurology, The Affiliated Wuxi Children's Hospital of Jiangnan University, No. 299 Qingyang Road, Wuxi, Jiangsu, 214023, China. FAU - Hua, Ying AU - Hua Y AD - Department of Neurology, The Affiliated Wuxi Children's Hospital of Jiangnan University, No. 299 Qingyang Road, Wuxi, Jiangsu, 214023, China. tomato331316@163.com. FAU - Tang, Hongwei AU - Tang H AD - Department of Neurology, The Affiliated Wuxi Children's Hospital of Jiangnan University, No. 299 Qingyang Road, Wuxi, Jiangsu, 214023, China. Tangliu229@126.com. FAU - Wang, Yanping AU - Wang Y AD - Department of Neurology, The Affiliated Wuxi Children's Hospital of Jiangnan University, No. 299 Qingyang Road, Wuxi, Jiangsu, 214023, China. ypwang591@aliyun.com. LA - eng PT - Journal Article DEP - 20260818 PL - England TA - Acta Epileptol JT - Acta epileptologica JID - 9918591884406676 PMC - PMC13483403 OTO - NOTNLM OT - Clinical characteristics OT - ENM OT - ESES OT - FCD OT - MPT COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Wuxi Children's Hospital affiliated to Jiangnan University, and parental consent was obtained (Approval number: WXCH2024-05-086). Declaration of AI use: The authors acknowledge the use of DeepSeek-V3 (accessed March 2026) to support English language polishing and the reorganization of Discussion section for clarity and flow. The specific prompts used included: "Please help me polish this paragraph" and "Please help me restructure the logic of this discussion section." Competing interests: The authors declare no competing interests. EDAT- 2026/08/18 07:46 MHDA- 2026/08/18 07:47 PMCR- 2026/08/18 CRDT- 2026/08/18 00:31 PHST- 2025/10/11 00:00 [received] PHST- 2026/07/28 00:00 [accepted] PHST- 2026/08/18 07:47 [medline] PHST- 2026/08/18 07:46 [pubmed] PHST- 2026/08/18 00:31 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - 10.1186/s42494-026-00273-3 [pii] AID - 273 [pii] AID - 10.1186/s42494-026-00273-3 [doi] PST - epublish SO - Acta Epileptol. 2026 Aug 18;8(1):31. doi: 10.1186/s42494-026-00273-3. PMID- 42608598 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260923 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 9 DP - 2026 Aug 18 TI - Gross motor function, functional level, physical performance, and muscle strength in preschool children newly diagnosed with cancer: Data from the RePlay trial. LID - 10.1007/s00431-026-07333-3 [doi] LID - 674 AB - Children with cancer experience treatment-related physical disruptions; however, these disruptions for preschool children newly diagnosed with cancer are poorly characterized. This study aimed to quantify gross motor function, functional level, physical performance, and muscle strength in preschool children aged 1-5 years newly diagnosed with cancer, and to compare these with age-expected normative values. This cross-sectional study includes data from the baseline assessment of 83 children (49% girls, 39 +/- 16 months old) enrolled in the Rehabilitation including structured active Play for preschoolers with cancer (RePlay) trial. Gross motor function was evaluated using the Peabody Developmental Motor Scales-Second Edition (PDMS-2); functional level was assessed using the Pediatric Evaluation of Disability Inventory (PEDI); physical performance was assessed using the 6-min walk test; and muscle strength was assessed using the KLS Martin Vigorimeter for handgrip strength. Mean gross motor quotient was 78.9 [95% CI: 73.6-84.2], indicating poor overall performance; 76% of the children performed below average or worse. Most children had difficulties with locomotion, with a mean standard score of 5.7 [95% CI: 4.8-6.6], indicating poor performance; 81% of the children performed below average or worse. PEDI mobility data were available for 83 children, with a mean normative standard score of 23.2 [95% CI: 20.0-26.3], indicating decreased functional level; 69% of the children scored below average. Mean handgrip strength was below average compared to healthy children; 0.17 [95% CI: 0.12-0.22]. CONCLUSION: These results show that preschoolers newly diagnosed with cancer have gross motor function, functional level, and muscle strength impairments, underlining the importance of targeted physical rehabilitation. CLINICALTRIALS: gov: NCT04672681. WHAT IS KNOWN: * Research has shown that children newly diagnosed with cancer have markedly impaired muscle strength, cardiorespiratory fitness, physical performance, and gross motor functions. * Gross motor function development is fundamentally important for preschoolers. However, research on gross motor function in children with cancer is limited, and existing studies often include broad age ranges (1-18 years), hindering clear evidence specific to preschoolers aged 1-5 years. WHAT IS NEW: * Preschool children newly diagnosed with cancer have clinically significant impairments of gross motor function and functional level. * Data on physical performance and muscle strength are limited, indicating poor feasibility for preschoolers with cancer. CI - (c) 2026. The Author(s). FAU - Pouplier, Anna AU - Pouplier A AD - Department of Pediatric and Adolescent Medicine, Juliane Marie Centre, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen, Denmark. anna.pouplier@regionh.dk. FAU - Christensen, Jan AU - Christensen J AD - Department of Occupational Therapy and Physiotherapy, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark. FAU - Schmidt-Andersen, Peter AU - Schmidt-Andersen P AD - Department of Pediatric and Adolescent Medicine, Juliane Marie Centre, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen, Denmark. FAU - Winther, Helle AU - Winther H AD - Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark. FAU - Larsen, Hanne Baekgaard AU - Larsen HB AD - Department of Pediatric and Adolescent Medicine, Juliane Marie Centre, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen, Denmark. AD - Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Fridh, Martin Kaj AU - Fridh MK AD - Department of Pediatric and Adolescent Medicine, Juliane Marie Centre, Copenhagen University Hospital - Rigshospitalet, Blegdamsvej 9, DK-2100, Copenhagen, Denmark. LA - eng SI - ClinicalTrials.gov/NCT04672681 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260818 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Female MH - Child, Preschool MH - Cross-Sectional Studies MH - Male MH - *Muscle Strength/physiology MH - Infant MH - *Physical Functional Performance MH - *Neoplasms/physiopathology/complications MH - *Motor Skills/physiology MH - Disability Evaluation PMC - PMC13481491 OTO - NOTNLM OT - Cancer OT - Functional level OT - Gross motor function OT - Handgrip strength OT - Newly diagnosed OT - Physical performance OT - Preschoolers COIS- Declarations. Ethics approval: This study was conducted in accordance with the Declaration of Helsinki II. The Regional Research Ethics Committee in the Capital Region of Denmark approved the RePlay trial (jr.nr.: H-20023949), and the Danish Data Protection Agency approved the handling of data (jr. nr.: P-2020-290). Consent to participate: Informed parental consent was obtained from all individual participants included in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/08/18 07:46 MHDA- 2026/08/18 07:47 PMCR- 2026/08/18 CRDT- 2026/08/18 00:11 PHST- 2026/05/06 00:00 [received] PHST- 2026/08/07 00:00 [accepted] PHST- 2026/08/05 00:00 [revised] PHST- 2026/08/18 07:47 [medline] PHST- 2026/08/18 07:46 [pubmed] PHST- 2026/08/18 00:11 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - 10.1007/s00431-026-07333-3 [pii] AID - 7333 [pii] AID - 10.1007/s00431-026-07333-3 [doi] PST - epublish SO - Eur J Pediatr. 2026 Aug 18;185(9):674. doi: 10.1007/s00431-026-07333-3. PMID- 42608021 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20260825 IS - 1746-1561 (Electronic) IS - 0022-4391 (Print) IS - 0022-4391 (Linking) VI - 96 IP - 9 DP - 2026 Sep TI - A Therapeutic Greenhouse Model for School-Based Health. PG - e70218 LID - 10.1111/josh.70218 [doi] LID - e70218 AB - BACKGROUND: The Therapeutic Greenhouse Program, located at an elementary school in an underserved community, offers a sustainable and reproducible model for school-based garden programming. Developed by a school-based health center, the program integrates medical and behavioral health services within an alternative therapeutic environment. It has been maintained since 2020 through strong partnerships with school staff, families, and community organizations. CONTRIBUTIONS TO PRACTICE: The program bridges hands-on food literacy education with clinical care delivery. Elementary school children engage in structured sessions that combine nutrition education, experiential learning, and behavioral health support within the garden setting. Close collaboration with teachers and community partners embeds the program into the daily school routine, fostering a multidisciplinary approach to student wellness. IMPLICATIONS FOR SCHOOL HEALTH POLICY, PRACTICE, AND EQUITY: This model supports policies that expand school-based health services into nontraditional care environments. It demonstrates the feasibility of interdisciplinary collaboration in delivering integrated, experiential health education. Furthermore, the program advances health equity by providing inclusive, nonstigmatizing access to health promotion and fresh food. CONCLUSIONS: By leveraging billable services, strategic partnerships, volunteer engagement, and small-scale revenue generation, the program provides a financially sustainable and replicable framework for integrating healthcare and education in school settings. CI - (c) 2026 American School Health Association. FAU - Casbarro, Nicole AU - Casbarro N AUID- ORCID: 0009-0004-6168-0246 AD - Community Health Center, Inc, Middletown, Connecticut, USA. AD - Quinnipiac University, Hamden, Connecticut, USA. FAU - Violano, Pina M AU - Violano PM AUID- ORCID: 0009-0004-4608-5529 AD - Quinnipiac University, Hamden, Connecticut, USA. LA - eng PT - Journal Article PL - United States TA - J Sch Health JT - The Journal of school health JID - 0376370 SB - IM MH - Humans MH - *School Health Services/organization & administration MH - Child MH - *Health Promotion/organization & administration/methods MH - *Health Education/organization & administration MH - *Gardening MH - Schools PMC - PMC13481118 OTO - NOTNLM OT - food literacy OT - school garden program OT - school health OT - school-based health center OT - therapeutic greenhouse COIS- The authors declare no conflicts of interest. EDAT- 2026/08/17 23:39 MHDA- 2026/08/17 23:40 PMCR- 2026/08/17 CRDT- 2026/08/17 19:43 PHST- 2026/07/06 00:00 [revised] PHST- 2025/09/07 00:00 [received] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/08/17 23:40 [medline] PHST- 2026/08/17 23:39 [pubmed] PHST- 2026/08/17 19:43 [entrez] PHST- 2026/08/17 00:00 [pmc-release] AID - JOSH70218 [pii] AID - 10.1111/josh.70218 [doi] PST - ppublish SO - J Sch Health. 2026 Sep;96(9):e70218. doi: 10.1111/josh.70218. PMID- 42607051 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20260902 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 8 DP - 2026 TI - The COCCOS study: A protocol for a multicentric quasi-experimental study of a healthcare transition program for young people with chronic conditions. PG - e0353932 LID - 10.1371/journal.pone.0353932 [doi] LID - e0353932 AB - INTRODUCTION: The growing number of adolescents and young adults (AYAs) living with chronic conditions highlights the need for effective healthcare transition programmes (TPs) to support the transfer from paediatric to adult care. Despite existing recommendations, many AYAs experience inadequate preparation, resulting in disrupted care and adverse health outcomes. The COCCOS project developed a co-designed TP to address these challenges. This study presents the protocol for an evaluation of this programme. METHODS AND ANALYSIS: A multicentric quasi-experimental pretest-posttest study will be conducted in two Belgian university hospitals. AYAs aged 17-18 years with type 1 diabetes, asthma, or obesity will be recruited into an intervention group receiving the COCCOS TP or a control group receiving usual care. The intervention consists of four structured consultations over 13-16 months, focusing on transition preparation, autonomy, and continuity of care. Primary outcome is transition readiness, measured using the Transition Readiness Assessment Questionnaire. Secondary outcomes include patient empowerment, medication adherence, health-related quality of life, and mental health. Data will be collected at baseline, transfer, and four months post-transfer. Cost-effectiveness will be assessed from a healthcare payer perspective using quality-adjusted life years. A mixed-methods process evaluation will examine implementation fidelity, acceptability, and contextual factors through observations, surveys, and interviews. The study is registered on ClinicalTrials.gov under identifier NCT07145671. DISCUSSION AND CONCLUSION: This study will provide comprehensive evidence on the feasibility, preliminary effectiveness, cost-effectiveness, and implementation of a co-designed TP in real-world clinical practice. By integrating clinical, economic, and process outcomes, it addresses key gaps in transitional care research. Findings will inform refinement of the programme and the design of a future large-scale trial, contributing to the development of sustainable, patient-centred transition care for AYAs with chronic conditions. CI - Copyright: (c) 2026 Van Wilder et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Van Wilder, Lisa AU - Van Wilder L AUID- ORCID: 0000-0003-4394-2623 AD - Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. FAU - Janssens, Natwarin AU - Janssens N AUID- ORCID: 0000-0002-4821-5444 AD - Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. AD - Department of Nursing and Midwifery, Faculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium. FAU - Van Hoorenbeeck, Kim AU - Van Hoorenbeeck K AUID- ORCID: 0000-0002-8812-4440 AD - Department of Pediatrics, Antwerp University Hospital, Antwerp, Belgium. AD - Laboratory of Experimental Medicine and Pediatrics (LEMP), University of Antwerp, Antwerp, Belgium. FAU - Vanden Wyngaert, Karsten AU - Vanden Wyngaert K AD - Ghent University Hospital, Ghent, Belgium. FAU - Goossens, Eva AU - Goossens E AD - Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. AD - Department of Patient Care, Antwerp University Hospital, Antwerp, Belgium. FAU - De Smedt, Delphine AU - De Smedt D AD - Department of Public Health and Primary Care, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. LA - eng SI - ClinicalTrials.gov/NCT07145671 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260817 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - Young Adult MH - Asthma/therapy MH - Belgium MH - Chronic Disease/therapy MH - Cost-Benefit Analysis MH - Diabetes Mellitus, Type 1/therapy MH - Obesity/therapy MH - Quality of Life MH - *Transition to Adult Care MH - Non-Randomized Controlled Trials as Topic MH - Multicenter Studies as Topic PMC - PMC13480643 COIS- The authors have declared that no competing interests exist. EDAT- 2026/08/17 17:45 MHDA- 2026/08/17 17:46 PMCR- 2026/08/17 CRDT- 2026/08/17 13:33 PHST- 2026/06/16 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/08/17 17:46 [medline] PHST- 2026/08/17 17:45 [pubmed] PHST- 2026/08/17 13:33 [entrez] PHST- 2026/08/17 00:00 [pmc-release] AID - PONE-D-26-23316 [pii] AID - 10.1371/journal.pone.0353932 [doi] PST - epublish SO - PLoS One. 2026 Aug 17;21(8):e0353932. doi: 10.1371/journal.pone.0353932. eCollection 2026. PMID- 42606737 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20261008 IS - 1437-9813 (Electronic) IS - 0179-0358 (Linking) VI - 42 IP - 1 DP - 2026 Aug 17 TI - Challenging the size: ovarian-sparing surgery in borderline huge pediatric ovarian tumors. LID - 344 [pii] LID - 10.1007/s00383-026-06582-5 [doi] AB - OBJECTIVE: Huge ovarian tumors in paediatric patients pose a surgical challenge, particularly in distinguishing tumor margins from ovarian parenchyma. While ovarian preservation is recommended for benign masses, concerns about tumor size may limit its application. This study evaluates the feasibility and outcomes of ovarian-sparing surgery (OSS) in children with giant ovarian tumors. MATERIALS AND METHODS: A retrospective study was realize on girls (< 18 years) who underwent surgery for ovarian masses with cystic lesions >/= 8 cm in our department (2009-2019). We included all patients classified O-RADS 3 and 4, and excluded O-RADS 5 in those OSS is contraindicated. Data on clinical presentation, imaging, tumor characteristics, surgical approach, histopathology, and follow-up were collected. Patients were categorized into two groups: OSS and oophorectomy (OV). RESULTS: Thirty patients (mean age: 13 years, range 3-17) were treated, including one with bilateral tumors. Palpable abdominal mass was the most common symptom (33.3%). The median tumor diameter was 148 mm (range 80-350 mm); 16 were purely cystic, 15 had mixed components, and 4 had calcifications. Tumor markers were negative except in 2 cases. Histology confirmed all tumors were benign (17 teratomas, 12 cystadenomas, 2 functional cysts). CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Mariani, Aurora AU - Mariani A AUID- ORCID: 0000-0001-6346-1259 AD - Department of Pediatric Surgery, Angers University Hospital, Angers, France. auroramariani@hotmail.it. AD - Department of Pediatric Surgery, Centre Hospitalo Universitaire, 4 rue Larrey, 49000, Angers, France. auroramariani@hotmail.it. FAU - Fiorenza, Venusia AU - Fiorenza V AD - Department of Pediatric Surgery, Gaslini Children Hospital, Genova, Italy. FAU - Hameury, Frederic AU - Hameury F AD - Department of Pediatric Surgery, Hopital Femme Mere Enfant, Bron, France. FAU - Goulin, Jeanne AU - Goulin J AD - Department of Pediatric Surgery, Hopital Femme Mere Enfant, Bron, France. FAU - Dijoud, Frederique AU - Dijoud F AD - Department of Pathology, Hopital Femme Mere Enfant, Bron, France. FAU - Gorduza, Daniela AU - Gorduza D AD - Department of Pediatric Surgery, St Etienne University Hospital, St Etienne, France. LA - eng PT - Journal Article DEP - 20260817 PL - Germany TA - Pediatr Surg Int JT - Pediatric surgery international JID - 8609169 SB - IM MH - Humans MH - Female MH - *Ovarian Neoplasms/surgery/pathology MH - Retrospective Studies MH - Child MH - Adolescent MH - *Organ Sparing Treatments/methods MH - Child, Preschool MH - *Ovariectomy/methods MH - Feasibility Studies MH - Tumor Burden MH - Ovary/surgery OTO - NOTNLM OT - Adolescent gynaecology OT - Fertility issues. OT - Ovarian sparing surgery OT - Ovarian tumor COIS- Declarations. Conflict of interest: The authors have no conflicts of interest relevant to this article. EDAT- 2026/08/17 17:45 MHDA- 2026/08/17 17:46 CRDT- 2026/08/17 11:15 PHST- 2026/05/19 00:00 [received] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/08/17 17:46 [medline] PHST- 2026/08/17 17:45 [pubmed] PHST- 2026/08/17 11:15 [entrez] AID - 10.1007/s00383-026-06582-5 [pii] AID - 10.1007/s00383-026-06582-5 [doi] PST - epublish SO - Pediatr Surg Int. 2026 Aug 17;42(1):344. doi: 10.1007/s00383-026-06582-5. PMID- 42606340 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20260921 IS - 1939-327X (Electronic) IS - 0012-1797 (Linking) VI - 75 IP - 10 DP - 2026 Oct 1 TI - Body Composition-Driven Phenotyping Reveals Obesity and Cardiometabolic Heterogeneity in Children Using a Tree-Like Representation. PG - 1810-1822 LID - 10.2337/db26-0136 [doi] AB - Traditional measures such as BMI do not fully capture obesity-related metabolic risks. Here, we examined DXA-derived body composition patterns in children (n = 11,238) using the discriminative dimensionality reduction tree algorithm, which was validated in an independent cohort (n = 2,001). The tree structure revealed a continuous landscape of body composition phenotypes, with distinct spatial gradients for fat and lean mass. Within the phenotypic tree, fat-dominant phenotypes clustered in the region of low dimension 1 and low dimension 2 (corresponding to the lower left branches), where they demonstrated significant spatial overlap with high-risk clusters for hypertension, elevated LDL cholesterol (LDL-C), total cholesterol, and triglycerides (TG) (Moran I >0.3, all P < 0.001). Meanwhile, phenotypes characterized by elevated lean mass coupled with increased adiposity were localized in the region of low dimension 1 and high dimension 2 (upper left branches), demonstrating an increased risk of low HDL-C and high TG (Moran I >0.6, all P < 0.001). In contrast, lean-dominant phenotypes clustered in the region of high dimension 1 and high dimension 2 (upper right branches), which were associated with a relatively low risk of hyperglycemia, insulin resistance, and high LDL-C (Moran I >0.1, all P < 0.001). For practical utility, we developed a publicly available web application to map individual data on the reference tree architecture, allowing for assessment of cardiometabolic risk. Our findings highlight the value of more precise body composition measures for early identification and prevention of obesity-related health problems. ARTICLE HIGHLIGHTS: Childhood obesity shows large differences in body composition and health risk that are not well captured by BMI or simple metabolic classifications, prompting the need for more precise characterization. This study aimed to determine whether a data-driven framework integrating detailed body composition measures could better describe obesity-related phenotypic heterogeneity and its relationship with cardiometabolic risk in children. We delineated a continuous body composition manifold encompassing fat-dominant, lean-dominant, and concomitant high-mass phenotypes, which captured diverging cardiometabolic risk trajectories and yielded modest incremental improvements in risk prediction. These findings support more precise risk stratification and provide a practical tool to improve early identification and prevention of obesity-related health complications in children. CI - (c) 2026 by the American Diabetes Association. FAU - Xiao, Pei AU - Xiao P AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Cheng, Hong AU - Cheng H AD - Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China. FAU - Xiong, Jingfan AU - Xiong J AD - Child and Adolescent Chronic Disease Prevention and Control Department, Shenzhen Center for Chronic Disease Control, Guangdong, China. FAU - Yan, Yinkun AU - Yan Y AUID- ORCID: 0000-0002-7758-744X AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Liu, Junting AU - Liu J AD - Child Health Big Data Research Center, Capital Center for Children's Health, Capital Medical University and Capital Institute of Pediatrics, Beijing, China. FAU - Liu, Li AU - Liu L AD - School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China. FAU - Dong, Hongbo AU - Dong H AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Li, Yan AU - Li Y AD - Child and Adolescent Chronic Disease Prevention and Control Department, Shenzhen Center for Chronic Disease Control, Guangdong, China. FAU - Ye, Peiyu AU - Ye P AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Fu, Liwan AU - Fu L AUID- ORCID: 0000-0002-7851-6379 AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Gao, Liwang AU - Gao L AD - School of Public Health, Capital Medical University, Beijing, China. FAU - Chen, Fangfang AU - Chen F AD - Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China. FAU - Shan, Xinying AU - Shan X AD - Department of Epidemiology, Capital Institute of Pediatrics, Beijing, China. FAU - Lan, Lina AU - Lan L AD - Child and Adolescent Chronic Disease Prevention and Control Department, Shenzhen Center for Chronic Disease Control, Guangdong, China. FAU - Li, Yanyan AU - Li Y AD - Child and Adolescent Chronic Disease Prevention and Control Department, Shenzhen Center for Chronic Disease Control, Guangdong, China. FAU - Mi, Jie AU - Mi J AUID- ORCID: 0000-0003-0630-8447 AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. LA - eng GR - L259068/Beijing Natural Science Foundation/ GR - 82204061/National Natural Science Foundation of China/ GR - 82373589/National Natural Science Foundation of China/ GR - SZSM 202311020/Sanming Project of Medicine in Shenzhen/ GR - CFH 2026-4G-2097/Capital's Funds for Health Improvement and Research/ PT - Journal Article PL - United States TA - Diabetes JT - Diabetes JID - 0372763 RN - 0 (Triglycerides) SB - IM MH - Humans MH - *Body Composition/physiology MH - Phenotype MH - Child MH - Male MH - Female MH - *Obesity MH - Body Mass Index MH - Absorptiometry, Photon MH - Algorithms MH - Triglycerides/blood MH - Adolescent MH - Adiposity/physiology EDAT- 2026/08/17 11:40 MHDA- 2026/09/21 17:47 CRDT- 2026/08/17 09:53 PHST- 2026/02/04 00:00 [received] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/09/21 17:47 [medline] PHST- 2026/08/17 11:40 [pubmed] PHST- 2026/08/17 09:53 [entrez] AID - 172389 [pii] AID - 10.2337/db26-0136 [doi] PST - ppublish SO - Diabetes. 2026 Oct 1;75(10):1810-1822. doi: 10.2337/db26-0136. PMID- 42605004 OWN - NLM STAT- MEDLINE DCOM- 20261011 LR - 20261011 IS - 1365-2184 (Electronic) IS - 0960-7722 (Print) IS - 0960-7722 (Linking) VI - 59 IP - 10 DP - 2026 Oct TI - Cystic Fibrosis and Colorectal Cancer Risk: Reprogramming of the Intestinal Epithelial Niche and Cell-State Plasticity in the CFTR Modulator Era. PG - e70272 LID - 10.1111/cpr.70272 [doi] LID - e70272 AB - Cystic fibrosis (CF) has shifted from a fatal paediatric lung disease to a multi-organ, lifespan-spanning disorder in which gastrointestinal (GI) complications and malignancies are increasingly prominent. With improved survival into mid- and late adulthood, aided by newborn screening, optimised nutrition and the advent of highly effective CF transmembrane conductance regulator (CFTR) modulators, implementation of colonoscopic surveillance has highlighted a several-fold increase in early-onset colorectal cancer (CRC) and a broader spectrum of intestinal pathology. In parallel, work in mouse models, human tissue and patient-derived intestinal organoids now places the CFTR at the centre of a complex epithelial compartment that integrates ion and pH homeostasis, mucus biology, microbiota, redox balance and immune/stromal function. In this review, we advance the hypothesis that CF may be conceptualised as a niche-centric hereditary CRC predisposition syndrome, in which germline CFTR dysfunction chronically destabilises epithelial identity in addition to increasing mutational burden. We synthesise evidence that CFTR loss remodels stem cell regulation, promotes hypoxia and oxidative stress, perturbs microbial ecosystems, drives chronic immune activation and stromal remodelling, and induces epithelial-mesenchymal plasticity (EMP) and DNA-damage vulnerability, collectively creating a pre-neoplastic intestinal ecosystem. We situate this model within contemporary CRC frameworks that emphasise cell-state transitions, hybrid epithelial-mesenchymal (E/M) states and specialised stromal niches, and we distinguish it from oncofoetal reprogramming, an APC-driven programme that CF does not clearly recapitulate. We propose that CF may provide a naturally occurring human context in which chronic epithelial stress sustains EMP-like pressure, a concept that requires direct validation in human CF intestinal tissue. Finally, we consider how CFTR modulators, microbiome-directed therapies and redox-targeted interventions might re-programme the CF intestinal niche and outline experimental and clinical strategies needed to determine whether early, ecosystem-level correction can prevent GI cancers in this high-risk population. CI - (c) 2026 The Author(s). Cell Proliferation published by Beijing Institute for Stem Cell and Regenerative Medicine and John Wiley & Sons Ltd. FAU - Umashankar, Bala AU - Umashankar B AUID- ORCID: 0000-0002-0796-5273 AD - School of Biomedical Sciences, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia. AD - Molecular and Integrative Cystic Fibrosis (miCF) Research Centre, UNSW Sydney, Sydney, New South Wales, Australia. FAU - Pankonien, Ines AU - Pankonien I AD - BioISI-Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, Lisbon, Portugal. FAU - Amaral, Margarida AU - Amaral M AUID- ORCID: 0000-0002-0828-8630 AD - BioISI-Biosystems & Integrative Sciences Institute, Faculty of Sciences, University of Lisbon, Lisbon, Portugal. FAU - Ooi, Chee Y AU - Ooi CY AUID- ORCID: 0000-0001-7111-0926 AD - Molecular and Integrative Cystic Fibrosis (miCF) Research Centre, UNSW Sydney, Sydney, New South Wales, Australia. AD - Department of Gastroenterology, Sydney Children's Hospitals Network, Sydney, New South Wales, Australia. AD - Sydney Children's Hospital Respiratory Department, Sydney Children's Hospitals Network, Sydney, New South Wales, Australia. FAU - Jarde, Thierry AU - Jarde T AUID- ORCID: 0000-0001-7483-8672 AD - Department of Anatomy and Developmental Biology, Monash University, Clayton, Victoria, Australia. AD - Monash Biomedicine Discovery Institute, Clayton, Victoria, Australia. FAU - Waters, Shafagh A AU - Waters SA AUID- ORCID: 0000-0003-1144-5411 AD - School of Biomedical Sciences, Faculty of Medicine and Health, UNSW Sydney, Sydney, New South Wales, Australia. AD - Molecular and Integrative Cystic Fibrosis (miCF) Research Centre, UNSW Sydney, Sydney, New South Wales, Australia. AD - Sydney Children's Hospital Respiratory Department, Sydney Children's Hospitals Network, Sydney, New South Wales, Australia. LA - eng GR - NHMRC_APP1188987/National Health and Medical Research Council/ GR - Sydney Children Hospital Network Foundation/ GR - Luminesce Alliance Research/ PT - Journal Article PT - Review DEP - 20260816 PL - England TA - Cell Prolif JT - Cell proliferation JID - 9105195 RN - 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator) SB - IM MH - Humans MH - *Cystic Fibrosis Transmembrane Conductance Regulator/metabolism/genetics MH - Animals MH - *Colorectal Neoplasms/pathology/metabolism MH - *Cystic Fibrosis/complications/pathology/metabolism MH - *Intestinal Mucosa/pathology/metabolism MH - Cell Plasticity PMC - PMC13478439 OTO - NOTNLM OT - CFTR OT - CFTR modulator therapy OT - colorectal cancer OT - cystic fibrosis OT - epithelial-mesenchymal plasticity OT - intestinal stem cells COIS- The authors declare no conflicts of interest. EDAT- 2026/08/17 05:38 MHDA- 2026/10/11 23:30 PMCR- 2026/08/16 CRDT- 2026/08/17 00:23 PHST- 2026/07/16 00:00 [revised] PHST- 2026/03/31 00:00 [received] PHST- 2026/08/07 00:00 [accepted] PHST- 2026/10/11 23:30 [medline] PHST- 2026/08/17 05:38 [pubmed] PHST- 2026/08/17 00:23 [entrez] PHST- 2026/08/16 00:00 [pmc-release] AID - CPR70272 [pii] AID - 10.1111/cpr.70272 [doi] PST - ppublish SO - Cell Prolif. 2026 Oct;59(10):e70272. doi: 10.1111/cpr.70272. Epub 2026 Aug 16. PMID- 42604984 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20260817 IS - 1117-1936 (Print) VI - 33 IP - 5 DP - 2026 Sep 1 TI - Luteinising Hormone-to-follicle-stimulating Hormone Ratio for Predicting Unexplained Infertility in Patients with Hypovitaminosis D. PG - 574-578 LID - 10.4103/npmj.npmj_638_25 [doi] AB - BACKGROUND: Hypovitaminosis D critically influences reproductive hormones in women of reproductive age. The luteinising hormone (LH)/follicle-stimulating hormone (FSH) ratio predicts poor ovulatory response. OBJECTIVE: To evaluate the correlation between the LH/FSH ratio and hypovitaminosis D as a predictor of unexplained infertility in women. MATERIALS AND METHODS: The study was a cross-sectional study with retrospective data collection spanning 2 years, from January 2023 to December 2024, conducted in the Fertility and Gynecology of El Assrar Center of Oran (Algeria). Patients were segregated into the following groups (deficient group vs. insufficient group vs. sufficient group). RESULTS: During the study period, 200 patients were admitted. Hypovitaminosis D status was observed in 44.5%. The mean age was 32.24 +/- 6.39 years (range: 18-47). In the deficient group, serum LH concentrations were markedly lower compared to the insufficient and sufficient groups (LH = 5.80 +/- 3.31 UI/L vs. 8.83 +/- 6.90 UI/L vs. 6.48 +/- 4.00 UI/L, P = 0.018; respectively). In contrast, the LH/FSH ratio was statistically higher in the deficient group compared to the insufficient and sufficient groups (LH/FSH ratio = 1.67 +/- 1.88 vs. 0.94 +/- 0.59 vs. 1.02 +/- 0.64, P = 0.018; respectively). In addition, the results revealed that the 4th quartile (odds ratios = 11.37 [4.13-22.00], P = 0.021) of LH/FSH ratio was statistically higher in patients with Vitamin D insufficiency and deficiency. The LH/FSH ratio was a significant predictor for unexplained infertility with a diagnostic accuracy of 0.724. CONCLUSIONS: Elevated LH/FSH ratio in women with hypovitaminosis D is significantly linked to unexplained infertility. Therefore, the LH/FSH ratio can serve as a reliable clinical marker for predicting successful pregnancy when evaluated alongside Vitamin D levels. CI - Copyright (c) 2026 Nigerian Postgraduate Medical Journal. FAU - Hamri, Walid Hassene AU - Hamri WH AD - Department of Biology, Faculty of Natural and Life Sciences, Mustapha Stambouli University, Mascara, Algeria. AD - Laboratory of Nutrition, Pathology, Agro-Biotechnology, and Health, Sidi-Bel-Abbes, Algeria. FAU - Chenni, Fatima Zohra AU - Chenni FZ AD - Department of Biology, Biotoxicology Laboratory, Faculty of Natural and Life Sciences, Djillali Liabes University, Sidi-Bel-Abbes, Algeria. FAU - Mirali, Chahnez Hadj Slimane AU - Mirali CHS AD - Fertility and Gynecology of Makhzan El Assrar Center, Oran, Algeria. LA - eng PT - Journal Article DEP - 20260817 PL - Nigeria TA - Niger Postgrad Med J JT - The Nigerian postgraduate medical journal JID - 9613595 RN - 9002-67-9 (Luteinizing Hormone) RN - 9002-68-0 (Follicle Stimulating Hormone) RN - 1406-16-2 (Vitamin D) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Vitamin D Deficiency/complications/blood MH - *Luteinizing Hormone/blood MH - Cross-Sectional Studies MH - Adult MH - Retrospective Studies MH - *Infertility, Female/blood/etiology/diagnosis MH - *Follicle Stimulating Hormone/blood MH - Middle Aged MH - Adolescent MH - Young Adult MH - Vitamin D/blood MH - Biomarkers/blood MH - Predictive Value of Tests OTO - NOTNLM OT - Hypovitaminosis D OT - luteinising hormone/follicle-stimulating hormone ratio OT - reproductive hormones OT - unexplained infertility EDAT- 2026/08/17 05:38 MHDA- 2026/08/17 05:39 CRDT- 2026/08/17 00:04 PHST- 2025/11/28 00:00 [received] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/08/17 05:39 [medline] PHST- 2026/08/17 05:38 [pubmed] PHST- 2026/08/17 00:04 [entrez] AID - 00130415-202609000-00004 [pii] AID - 10.4103/npmj.npmj_638_25 [doi] PST - ppublish SO - Niger Postgrad Med J. 2026 Sep 1;33(5):574-578. doi: 10.4103/npmj.npmj_638_25. Epub 2026 Aug 17. PMID- 42604857 OWN - NLM STAT- Publisher LR - 20260816 IS - 1557-9034 (Electronic) IS - 1092-6429 (Linking) DP - 2026 Aug 16 TI - Robotic Pancreaticoduodenectomy in Pediatric Patients: First Two Reported Cases in the United States. PG - 10926429261478780 LID - 10.1177/10926429261478780 [doi] AB - BACKGROUND: Pancreaticoduodenectomy (Whipple procedure) is rarely required in children, but remains the standard of care for resectable pancreatic head tumors. Robotic pancreaticoduodenectomy (RPD) has been increasingly performed in adults, demonstrating safety, feasibility, and in some series, superior perioperative outcomes compared with open surgery. In children, however, there are only three published case reports worldwide. METHODS: We describe two adolescent females with pancreatic head solid pseudopapillary neoplasms (SPNs) who underwent RPD at high-volume U.S. CENTERS: Both cases were managed by multidisciplinary teams including pediatric surgeons and adult surgical oncologists experienced in robotic pancreatic surgery. RESULTS: Case 1: A 13-year-old underwent robotic pylorus-preserving pancreaticoduodenectomy utilizing intraoperative Indocyanine Green Firefly and ultrasound to assess critical anatomy. Reconstruction was performed with Blumgart pancreaticojejunostomy and hepaticojejunostomy. She advanced to diet by postoperative day (POD) 3 and was discharged on POD 3. Case 2: A 17-year-old underwent RPD with pylorus preservation in a similar fashion at an adult hospital. Her recovery was uncomplicated, drains were removed on POD 4, and she was discharged on POD 5. Final pathology in both patients confirmed SPN with negative margins. CONCLUSIONS: These represent the first pediatric RPDs reported in the United States and the first using the da Vinci Xi platform. Our experience demonstrates that pediatric RPD is feasible and safe when performed in collaboration with high-volume adult robotic pancreatic programs. Given the rarity of pediatric pancreatic tumors, collaborative registries and continued reporting are essential to define outcomes and guide best practice. FAU - Zamora, Irving J AU - Zamora IJ AD - Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Sims, Jessica K AU - Sims JK AD - Vanderbilt University School of Medicine, Nashville, Tennessee, USA. FAU - Gupta, Vikas S AU - Gupta VS AD - Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - D'Cruz, Roshan J AU - D'Cruz RJ AD - Department of Pediatric Surgery, Medical College of Georgia, Augusta, Georgia, USA. FAU - Jacobson, Jillian AU - Jacobson J AD - Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Chara, Alejandro O AU - Chara AO AUID- ORCID: 0009-0009-0408-0830 AD - Department of General Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Johnson, Kevin N AU - Johnson KN AD - Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Gamboa, Anthony M AU - Gamboa AM AD - Department of Gastroenterology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Benedetti, Daniel J AU - Benedetti DJ AUID- ORCID: 0000-0003-1524-3518 AD - Department of Pediatric Hematology/Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Polanco, Patricio M AU - Polanco PM AD - Department of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. FAU - Zeh, Herbert J 3rd AU - Zeh HJ 3rd AD - Department of Surgical Oncology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. FAU - Padmanaban, Sekhar AU - Padmanaban S AD - Department of Surgical Oncology, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Lovvorn, Harold N 3rd AU - Lovvorn HN 3rd AD - Department of Pediatric Surgery, Vanderbilt University Medical Center, Nashville, Tennessee, USA. FAU - Pandya, Samir AU - Pandya S AD - Department of Pediatric Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA. LA - eng PT - Journal Article DEP - 20260816 PL - United States TA - J Laparoendosc Adv Surg Tech A JT - Journal of laparoendoscopic & advanced surgical techniques. Part A JID - 9706293 SB - IM OTO - NOTNLM OT - pancreaticoduodenectomy OT - pediatric surgery OT - robotic surgery OT - surgical education EDAT- 2026/08/16 23:36 MHDA- 2026/08/16 23:36 CRDT- 2026/08/16 22:33 PHST- 2026/08/16 23:36 [medline] PHST- 2026/08/16 23:36 [pubmed] PHST- 2026/08/16 22:33 [entrez] AID - 10.1177/10926429261478780 [doi] PST - aheadofprint SO - J Laparoendosc Adv Surg Tech A. 2026 Aug 16:10926429261478780. doi: 10.1177/10926429261478780. PMID- 42604540 OWN - NLM STAT- Publisher LR - 20260825 IS - 1754-9515 (Electronic) IS - 1754-9507 (Linking) DP - 2026 Aug 16 TI - Assessment and diagnosis of Paediatric Feeding Disorder: A scoping review of assessment tools and psychometric properties. PG - 1-13 LID - 10.1080/17549507.2026.2713492 [doi] AB - PURPOSE: Paediatric Feeding Disorder occurs when oral intake is not age-appropriate and associated with impaired medical, nutritional, feeding skill, and/or psychosocial dysfunction. Psychometric properties of feeding assessments are variable, with unclear mapping to the Paediatric Feeding Disorder criteria. We aimed to explore paediatric feeding and swallowing assessment tools mapped to Paediatric Feeding Disorder domains and narratively analyse the psychometric properties. METHOD: This systematic scoping review utilised three databases (Medline, Embase, Web of Science). Studies written in English regarding children 0;6 months to 3;11 years with psychometrics on assessment of Paediatric Feeding Disorder were included. RESULT: 32,322 papers met inclusion criteria, and 137 papers were included in final extraction. Ninety-five feeding assessments were identified; 66.3% parent-reported questionnaires, 31.6% clinician assessments, and 2.1% clinician or caregiver rating scales. Of these, 87% of assessments included a combination of Paediatric Feeding Disorder domains. Psychometric properties were reported on 520 occasions, the highest being internal consistency (13.5%). CONCLUSION: Diagnosis of Paediatric Feeding Disorder requires use of feeding assessments with the strongest psychometric evidence to comprehensively assess all four Paediatric Feeding Disorder domains. Assessments should incorporate parent-reported and clinician assessment to synergise caregiver perspectives with clinical expertise. Further research is needed to enhance reliability and validity testing of paediatric feeding assessments to form a comprehensive Paediatric Feeding Disorder diagnosis. FAU - Wanless, Rachel AU - Wanless R AUID- ORCID: 0000-0003-2528-0945 AD - Curtin University, Perth, Australia. FAU - Claessen, Mary AU - Claessen M AUID- ORCID: 0000-0002-1087-5041 AD - Speech Pathology Australia, Melbourne, Australia. FAU - Gucciardi, Daniel F AU - Gucciardi DF AUID- ORCID: 0000-0001-5448-3990 AD - Curtin University, Perth, Australia. FAU - Smart, Sharon AU - Smart S AUID- ORCID: 0000-0002-5882-4673 AD - Curtin University, Perth, Australia. LA - eng PT - Journal Article PT - Review DEP - 20260816 PL - England TA - Int J Speech Lang Pathol JT - International journal of speech-language pathology JID - 101320232 SB - IM OTO - NOTNLM OT - Paediatric Feeding Disorder OT - assessment OT - diagnosis OT - feeding OT - psychometrics OT - swallowing EDAT- 2026/08/16 17:36 MHDA- 2026/08/16 17:36 CRDT- 2026/08/16 11:42 PHST- 2026/08/16 17:36 [pubmed] PHST- 2026/08/16 17:36 [medline] PHST- 2026/08/16 11:42 [entrez] AID - 10.1080/17549507.2026.2713492 [doi] PST - aheadofprint SO - Int J Speech Lang Pathol. 2026 Aug 16:1-13. doi: 10.1080/17549507.2026.2713492. PMID- 42603809 OWN - NLM STAT- Publisher LR - 20260815 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Aug 15 TI - Associations of mental health with subsequent weight development during a 4-year follow-up in adolescence. LID - 10.1038/s41390-026-05361-1 [doi] AB - BACKGROUND: Although obesity and mental health problems represent two of the most pressing public health challenges, their developmental interplay remains insufficiently understood. Thus, we examined how depressive and anxiety symptoms, self-esteem, and psychological resilience are associated with weight development during adolescence. METHODS: We included 1280 11-year-old children from the Finnish Health in Teens cohort, following 814 of them for 4.3 years. Mental health was assessed with validated self-administered scales at age 11. Psychological resilience was determined by complete mental health after exposure to stressful life events. Body mass index z-score (BMIz) and waist-to-height ratio (WtHr) were calculated at ages 11 and 16. RESULTS: In models adjusted for sex, age, physical activity, dietary pattern, puberty status, caregivers' BMI and education level, depressive symptoms were associated with higher baseline BMIz but smaller increases in mean BMIz thereafter (p = 0.030). High self-esteem was associated with lower baseline BMIz, yet with steeper increases over follow-up (adjusted model, p = 0.021). Anxiety symptoms and resilience were not associated with BMIz after adjustments. Similar patterns were observed for WtHr. CONCLUSION: Findings highlight that mental health is associated with physical growth in adolescence, emphasizing the need to consider mental health in understanding and addressing patterns of weight development and their underlying dynamics. IMPACT: This study provides up-to-date, longitudinal evidence on how mental health shapes subsequent weight development during the critical and rapid growth period of adolescence. Both positive and negative dimensions of mental health play a role in shaping adolescent weight development, with evidence that some youths experiencing mental health difficulties exhibited smaller increases in BMI z-score, even when starting from a higher baseline BMI. It should be acknowledged that in contemporary society, adolescents with mental health difficulties may not necessarily present immediate excessive weight gain but instead follow stable or even declining weight trajectories. CI - (c) 2026. The Author(s). FAU - Ankkuri, Emilia AU - Ankkuri E AD - Folkhalsan Research Centre, Helsinki, Finland. AD - Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Lommi, Sohvi AU - Lommi S AD - Folkhalsan Research Centre, Helsinki, Finland. AD - Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Granroth-Wilding, Hanna AU - Granroth-Wilding H AD - Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Lahti, Jari AU - Lahti J AD - Folkhalsan Research Centre, Helsinki, Finland. AD - Department of Psychology and Logopedics, Faculty of Medicine, University of Helsinki, Helsinki, Finland. FAU - Viljakainen, Heli AU - Viljakainen H AD - Folkhalsan Research Centre, Helsinki, Finland. heli.viljakainen@helsinki.fi. AD - Faculty of Medicine, University of Helsinki, Helsinki, Finland. heli.viljakainen@helsinki.fi. LA - eng PT - Journal Article DEP - 20260815 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Informed consent: Written informed consent was obtained from Finnish Health in Teens participating adolescents and their caregivers. EDAT- 2026/08/16 05:35 MHDA- 2026/08/16 05:35 CRDT- 2026/08/15 23:28 PHST- 2025/09/19 00:00 [received] PHST- 2026/07/04 00:00 [accepted] PHST- 2026/06/15 00:00 [revised] PHST- 2026/08/16 05:35 [medline] PHST- 2026/08/16 05:35 [pubmed] PHST- 2026/08/15 23:28 [entrez] AID - 10.1038/s41390-026-05361-1 [pii] AID - 10.1038/s41390-026-05361-1 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Aug 15. doi: 10.1038/s41390-026-05361-1. PMID- 42602839 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260815 LR - 20260816 IS - 2055-7647 (Print) IS - 2055-7647 (Electronic) IS - 2055-7647 (Linking) VI - 12 IP - 3 DP - 2026 TI - Exploring the impact of revised physical activity guidelines on children and adolescents: an analysis of large Australian and New Zealand studies. PG - e003119 LID - 10.1136/bmjsem-2025-003119 [doi] LID - e003119 AB - OBJECTIVES: Around 80% of children/adolescents globally do not meet recommended levels of physical activity (PA). The 2020 WHO consensus updated PA guidelines, changing from '60 minutes of PA/day' to at least 'an average of 60 min/day'. This means that attaining 420 min/week expresses the minimum threshold for PA.This analysis examined the effects of the changed guidelines on children/adolescents meeting PA guidelines. A coprimary research question examines single-item PA questions to determine the number of days of 60 min of activity that best reflect meeting the new PA guideline. METHODS: Data were from five population-level Australian and New Zealand surveys (two representative population surveillance datasets and three large community interventions). PA questions included the single item question (days/week of 60 min) and detailed PA measures including International Physical Activity Questionnaire-adolescent questions. The single-item analysis used receiver operating characteristic (ROC) curves to identify the best fit between the single-item and more extensive PA measures (maximising sensitivity and specificity). RESULTS: The proportion meeting the old PA guidelines ranged from 28-55%, compared with 35-84% meeting the new guideline (average absolute increase of 26.2%). ROC analysis described areas under the ROC curve between 0.728 and 0.907. The best fit (Youden's Index >0.5) was 4-5 days/week where the single item best classified children and adolescents meeting the new guideline. CONCLUSIONS: The new guideline classified 26% more children and adolescents meeting updated PA guidelines. National research reports should use updated PA guideline criteria, and for surveillance, 4-5 reported days/week on the single PA question best estimates meeting the PA guideline threshold. CI - Copyright (c) World Health Organization 2026. Licensee BMJ. FAU - Bauman, Adrian AU - Bauman A AUID- ORCID: 0000-0002-0369-4621 AD - Sydney School of Public Health, Prevention Research Collaboration, The University of Sydney, Sydney, New South Wales, Australia. FAU - Owen, Katherine AU - Owen K AUID- ORCID: 0000-0001-5248-3030 AD - The University of Sydney, Sydney, New South Wales, Australia. FAU - Smith, Janette L AU - Smith JL AD - NSW Ministry of Health Population and Public Health Division, St Leonards, New South Wales, Australia. FAU - Wolfenden, Luke AU - Wolfenden L AD - School of Medicine and Public Health, The University of Newcastle Australia, Newcastle, New South Wales, Australia. FAU - Nathan, Nicole AU - Nathan N AUID- ORCID: 0000-0002-7726-1714 AD - School of Medicine and Public Health, The University of Newcastle Australia, Newcastle, New South Wales, Australia. FAU - Richards, Justin AU - Richards J AD - Te Hau Kori - Centre for Physical Activity and Wellbeing, Victoria University of Wellington, Wellington, New Zealand. LA - eng PT - Journal Article DEP - 20260812 PL - England TA - BMJ Open Sport Exerc Med JT - BMJ open sport & exercise medicine JID - 101681007 PMC - PMC13475078 OTO - NOTNLM OT - Exercise OT - Physical activity OT - Surveillance COIS- None declared. EDAT- 2026/08/15 13:47 MHDA- 2026/08/15 13:48 PMCR- 2026/08/12 CRDT- 2026/08/15 06:11 PHST- 2025/11/24 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/08/15 13:48 [medline] PHST- 2026/08/15 13:47 [pubmed] PHST- 2026/08/15 06:11 [entrez] PHST- 2026/08/12 00:00 [pmc-release] AID - bmjsem-2025-003119 [pii] AID - 10.1136/bmjsem-2025-003119 [doi] PST - epublish SO - BMJ Open Sport Exerc Med. 2026 Aug 12;12(3):e003119. doi: 10.1136/bmjsem-2025-003119. eCollection 2026. PMID- 42602124 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260815 LR - 20260816 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 7 DP - 2026 Jul TI - Evaluation of a Caregiver-Completed Questionnaire for Assessing Early Childhood Caries Risk: A Cross-Sectional Study. PG - e112685 LID - 10.7759/cureus.112685 [doi] LID - e112685 AB - Introduction Early childhood caries (ECC) is one of the most prevalent chronic diseases affecting preschool children worldwide and can adversely affect oral health, nutrition, growth, and quality of life. Early identification of children at risk is essential for implementing timely preventive interventions. Caregiver-completed screening tools may offer a simple and cost-effective approach to identifying children who require further dental evaluation. Therefore, the present study aimed to evaluate the diagnostic performance of a self-developed, caregiver-completed questionnaire for identifying ECC among preschool children, using clinical examination as the reference standard. Materials and methods A cross-sectional study was conducted among 150 caregiver-child dyads, including children aged 3-6 years. Caregivers completed a self-developed, 15-item questionnaire covering feeding practices, dietary habits, oral hygiene practices, dental history, and caregiver-related factors. Content validation was performed by an expert panel, followed by pilot testing and reliability assessment. All children subsequently underwent a clinical examination for the diagnosis of ECC. Internal consistency was evaluated using Cronbach's alpha. Receiver operating characteristic (ROC) curve analysis was performed to determine the optimal questionnaire cutoff score. Sensitivity, specificity, predictive values, likelihood ratios, area under the curve (AUC), and Cohen's kappa were calculated. Results Clinical examination identified ECC in 90 (60.0%) children, while 60 (40.0%) children did not have ECC. Questionnaire scores were significantly higher among children with ECC (19.4 +/- 4.6) than among those without ECC (10.2 +/- 3.8; p < 0.001). The questionnaire demonstrated good internal consistency, with an overall Cronbach's alpha of 0.86. ROC curve analysis revealed an AUC of 0.884 (95% CI: 0.830-0.938). The optimal cutoff score was >/=15, yielding a sensitivity of 82.2%, specificity of 86.7%, positive predictive value of 90.2%, and negative predictive value of 76.5%. The positive and negative likelihood ratios were 6.17 and 0.205, respectively. Agreement analysis demonstrated an observed agreement of 84.0% and a Cohen's kappa coefficient of 0.672, indicating substantial agreement with the clinical diagnosis. Conclusion The caregiver-completed ECC questionnaire demonstrated good reliability, substantial agreement with clinical examination findings, and good diagnostic performance as a screening tool. The questionnaire may serve as a simple, non-invasive, and cost-effective tool for the early identification of children with or at risk of ECC and may facilitate timely preventive interventions in community and clinical settings. CI - Copyright (c) 2026, Gunnam et al. FAU - Gunnam, Divya Sree AU - Gunnam DS AD - Department of Public Health, Master of Public Health, University of New Haven, West Haven, USA. FAU - Ravikumar, Akshitha AU - Ravikumar A AD - Department of Public Health Dentistry, Panineeya Institute of Dental Sciences and Research Centre, Hyderabad, IND. FAU - Chokshi, Akshat A AU - Chokshi AA AD - Department of Dentistry, Taunton Village Dental, Oshawa, CAN. FAU - Chauhan, Sameer AU - Chauhan S AD - Department of Prosthodontics, K. M. Shah Dental College and Hospital, Sumandeep Vidyapeeth (Deemed to be University), Vadodara, IND. FAU - Sreedhar, Gayathri AU - Sreedhar G AD - Department of Public Health Dentistry, Azeezia College of Dental Sciences and Research, Adichanalloor, IND. FAU - Kumar B, Prashanth AU - Kumar B P AD - Department of Pedodontics and Preventive Dentistry, Tirumala Institute of Dental Sciences and Research Centre, Nizamabad, IND. LA - eng PT - Journal Article DEP - 20260714 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13473709 OTO - NOTNLM OT - caregivers OT - dental caries risk assessment OT - early childhood caries OT - oral health screening OT - questionnaires COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee, Azeezia College of Dental Sciences and Research, Kollam, Kerala, India issued approval AEC/2022/29. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/08/15 13:47 MHDA- 2026/08/15 13:48 PMCR- 2026/07/14 CRDT- 2026/08/15 05:11 PHST- 2026/07/14 00:00 [accepted] PHST- 2026/08/15 13:48 [medline] PHST- 2026/08/15 13:47 [pubmed] PHST- 2026/08/15 05:11 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 10.7759/cureus.112685 [doi] PST - epublish SO - Cureus. 2026 Jul 14;18(7):e112685. doi: 10.7759/cureus.112685. eCollection 2026 Jul. PMID- 42602011 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260815 LR - 20260816 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Analysis of influencing factors and nomogram of attention-deficit hyperactivity disorder in school-age children. PG - 1830784 LID - 10.3389/fpsyt.2026.1830784 [doi] LID - 1830784 AB - INTRODUCTION: Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in school-aged children (6-13 years) that can lead to significant functional impairment if not identified early. This study aims to identify factors associated with ADHD among school-age children and evaluate the predictive value of a risk nomogram. METHODS: We conducted a retrospective study including 155 school-age children diagnosed with ADHD at the Minhang District Mental Health Centre (Shanghai) between June 2022 and May 2025, and 155 age-matched healthy controls who underwent physical examination during the same period. Clinical and demographic data were collected via standardized questionnaires. Logistic regression analyses were performed to identify risk factors, and a nomogram prediction model was constructed. Model performance was assessed using the area under the receiver operating characteristic curve (AUC), calibration plots, and the Hosmer-Lemeshow test. RESULTS: Multivariate logistic analysis identified maternal alcohol consumption during pregnancy (OR = 6.975), maternal smoking during pregnancy (OR = 3.785), maternal anxiety and depression during pregnancy (OR = 3.826), family history of ADHD (OR = 9.449), parental violence (OR = 3.369), difficulty falling asleep (OR = 7.317), and daily screen time >/= 2 hours (OR = 1.755) as independent risk factors for ADHD. Family harmony was identified as a protective factor (OR = 0.455). The nomogram prediction model demonstrated good discriminative ability with an AUC of 0.817 (95% CI: 0.769-0.864) at a cut-off value of logit(P) > 0.471. The model showed satisfactory calibration (Hosmer-Lemeshow test, P = 0.355) with a sensitivity of 75.48% and specificity of 76.77%. DISCUSSION: ADHD in school-age children is influenced by multiple factors, including prenatal exposures, family environment, sleep patterns, and daily screen time. The nomogram prediction model developed in this study demonstrates good predictive performance and may serve as a preliminary tool for early identification of at-risk children, though external validation is needed before clinical implementation. These findings highlight the importance of targeted preventive interventions addressing modifiable risk factors, particularly focusing on prenatal care, family harmony, sleep hygiene, and screen time management, to reduce the probability of ADHD in school-age children. CI - Copyright (c) 2026 Li, Zhang, Jiang, Tao, Wang and Jin. FAU - Li, Bo AU - Li B AD - Shanghai Minhang District Mental Health Center, Shanghai, China. FAU - Zhang, Wei Bo AU - Zhang WB AD - Shanghai Mental Health Center, Shanghai, China. FAU - Jiang, Chao AU - Jiang C AD - Shanghai Minhang District Mental Health Center, Shanghai, China. FAU - Tao, Jing AU - Tao J AD - Shanghai Mental Health Center, Shanghai, China. FAU - Wang, Li Na AU - Wang LN AD - Shanghai Minhang District Mental Health Center, Shanghai, China. FAU - Jin, Jin AU - Jin J AD - Shanghai Mental Health Center, Shanghai, China. LA - eng PT - Journal Article DEP - 20260731 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13473084 OTO - NOTNLM OT - ADHD OT - nomogram OT - prediction model OT - risk factors OT - school-aged children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/15 05:36 MHDA- 2026/08/15 05:37 PMCR- 2026/07/31 CRDT- 2026/08/15 04:59 PHST- 2026/03/14 00:00 [received] PHST- 2026/05/30 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/08/15 05:37 [medline] PHST- 2026/08/15 05:36 [pubmed] PHST- 2026/08/15 04:59 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1830784 [doi] PST - epublish SO - Front Psychiatry. 2026 Jul 31;17:1830784. doi: 10.3389/fpsyt.2026.1830784. eCollection 2026. PMID- 42601769 OWN - NLM STAT- MEDLINE DCOM- 20260815 LR - 20260819 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 33 DP - 2026 Aug 14 TI - Central adiposity reflected by the weight-adjusted waist index and spirometric parameters in US children and adolescents: A cross-sectional analysis of NHANES 2007 to 2012. PG - e50200 LID - 10.1097/MD.0000000000050200 [doi] LID - e50200 AB - Obesity impairs pulmonary function. This study aimed to investigate the potential relationship between the weight-adjusted waist index (WWI), a novel metric for measuring adiposity, and pulmonary function in children and adolescents. This cross-sectional study used extensive data on WWI and pulmonary function metrics from the 2007 to 2012 National Health and Nutrition Examination Survey. The WWI calculation entails dividing waist circumference (cm) by the square root of weight (kg). Z-scores for each lung function measure were derived from Global Lung Function Initiative references. We employed a weighted multivariate logistic regression model to ascertain the association between lung function and WWI. The application of smooth curve fitting validated the linearity of the relationships. Subgroup analysis and evaluation of interactions were conducted as well. Across all statistical models, no significant association was observed between WWI and forced expiratory volume in 1 second (FEV1) z-score. However, WWI demonstrated a significant positive correlation with forced vital capacity (FVC) z-score. Importantly, a significant negative correlation was consistently found between WWI and FEV1/FVC z-score. In the model with all adjustments, each unit rise in WWI was associated with a decrease of 0.395 in FEV1/FVC z-score (beta = -0.395, 95% confidence interval: -0.496, -0.295) and an increase of 0.292 in FVC z-score (beta = 0.292, 95% confidence interval: 0.186, 0.398). This study finds a significant negative association between WWI and FEV1/FVC z-score. This highlights the necessity for sustained WWI surveillance to guide public health initiatives. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Wu, Meijuan AU - Wu M AD - Department of Pulmonary and Critical Care Medicine, The Second Hospital of Sanming, Sanming, Fujian Province, PR China. FAU - Xie, Qihua AU - Xie Q FAU - Zhang, Aimei AU - Zhang A FAU - Lin, Yongping AU - Lin Y LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Cross-Sectional Studies MH - Adolescent MH - Nutrition Surveys MH - Female MH - Child MH - United States/epidemiology MH - Male MH - *Waist Circumference/physiology MH - Spirometry MH - Forced Expiratory Volume/physiology MH - Vital Capacity/physiology MH - *Obesity, Abdominal/physiopathology/epidemiology MH - *Adiposity/physiology PMC - PMC13480898 OTO - NOTNLM OT - NHANES OT - children and adolescents OT - obesity OT - pulmonary function OT - weight-adjusted waist index COIS- The authors have no funding and conflicts of interest to declare. EDAT- 2026/08/15 05:36 MHDA- 2026/08/15 05:37 PMCR- 2026/08/14 CRDT- 2026/08/15 01:00 PHST- 2026/01/27 00:00 [received] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/08/15 05:37 [medline] PHST- 2026/08/15 05:36 [pubmed] PHST- 2026/08/15 01:00 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - 00005792-202608140-00097 [pii] AID - MD-D-26-01188 [pii] AID - 10.1097/MD.0000000000050200 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Aug 14;105(33):e50200. doi: 10.1097/MD.0000000000050200. PMID- 42601187 OWN - NLM STAT- Publisher LR - 20260928 IS - 1468-6244 (Electronic) IS - 0022-2593 (Print) IS - 0022-2593 (Linking) DP - 2026 Aug 14 TI - Childhood-onset neurodegeneration and brain atrophy: defining UBTF-related developmental regression and progressive ataxia. LID - jmg-2025-111356 [pii] LID - 10.1136/jmg-2025-111356 [doi] AB - BACKGROUND: The heterozygous variant c.628G>A (p.Glu210Lys) in UBTF (upstream binding transcription factor) causes childhood-onset neurodegeneration with brain atrophy (CONDBA) (OMIM # 600673), characterised by early normal or mildly delayed development followed by regression, with individuals frequently experiencing movement disorders. This study defines the natural history of this rare disorder and explores potential biomarkers in humans and mice. METHODS: Caregivers of individuals with CONDBA completed cross-sectional surveys detailing genetic, developmental and clinical features. Patients evaluated in a neurogenetics clinic underwent Brief Ataxia Rating Scale (BARS) assessments compared with remotely collected wrist and ankle accelerometry data. Neurofilament light chain (NFL) levels were assessed in the clinic cohort and in a Ubtf E210K knock-in mouse model. RESULTS: All 11 caregiver surveys reported onset of neurodevelopmental regression (median 3.5 years, range 0.5-5 years), at times following anaesthesia or illness and 82% developed ataxia. Motor activity data from five participants (median 11.8 years, range 8.1-12.5 years) had high test-retest reliability, correlated with ataxia severity as measured by the BARS, and showed declines across multiple measures over the study period. NFL was abnormally elevated in both humans and the mouse model. CONCLUSION: UBTF-related CONDBA presents with early normal or mildly delayed development followed by regression and progressive ataxia. Wearable accelerometers provide a reliable measure of disease severity, and elevated NFL may serve as a biomarker of neuronal injury in both humans and animal models. CI - (c) Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Nagy, Amanda AU - Nagy A AUID- ORCID: 0000-0001-8116-4805 AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA anagy2@mgb.org. FAU - Luddy, Anna AU - Luddy A AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Molay, Francine AU - Molay F AD - Division of Clinical Research, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - McLaughlin, Haley AU - McLaughlin H AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - De La Rosa Abreu, Lizbeth AU - De La Rosa Abreu L AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Becker, Catherine AU - Becker C AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Terrey, Markus AU - Terrey M AD - Rare Disease Translational Center, The Jackson Laboratory, Bar Harbor, Maine, USA. FAU - Lutz, Cathleen M AU - Lutz CM AD - Rare Disease Translational Center, The Jackson Laboratory, Bar Harbor, Maine, USA. AD - JAX Center for Precision Genetics, The Jackson Laboratory, Bar Harbor, Maine, USA. FAU - Gupta, Anoopum AU - Gupta A AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Eichler, Florian S AU - Eichler FS AD - Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, USA. LA - eng GR - R01 NS134597/NS/NINDS NIH HHS/United States GR - U42 OD010921/OD/NIH HHS/United States GR - U54 NS115052/NS/NINDS NIH HHS/United States GR - U54 OD030187/OD/NIH HHS/United States PT - Journal Article DEP - 20260814 PL - England TA - J Med Genet JT - Journal of medical genetics JID - 2985087R SB - IM PMC - PMC13614006 MID - NIHMS2209294 OTO - NOTNLM OT - Central Nervous System Diseases OT - Cerebellar Diseases OT - Movement Disorders OT - Neurodegenerative Diseases OT - Pediatrics COIS- Competing interests: For the methods for extracting and characterising submovements from wearable sensor data, a PCT (US2022/081374) was filed on 12 December 2022, titled 'System and method for clinical disorder assessment'. An earlier US Provisional Application (Serial No. 63/288,619) was filed on 12 December 2021. The patent applicant is the institution (Massachusetts General Hospital) and inventor is AG. EDAT- 2026/08/14 23:37 MHDA- 2026/08/14 23:37 PMCR- 2026/09/25 CRDT- 2026/08/14 21:23 PHST- 2025/11/11 00:00 [received] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/08/14 23:37 [medline] PHST- 2026/08/14 23:37 [pubmed] PHST- 2026/08/14 21:23 [entrez] PHST- 2026/09/25 00:00 [pmc-release] AID - jmg-2025-111356 [pii] AID - 10.1136/jmg-2025-111356 [doi] PST - aheadofprint SO - J Med Genet. 2026 Aug 14:jmg-2025-111356. doi: 10.1136/jmg-2025-111356. PMID- 42600838 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260909 IS - 1095-9319 (Electronic) IS - 0026-2862 (Linking) VI - 168 DP - 2026 Nov TI - Evaluation of retinochoroidal microvascular parameters and biochemical markers in childhood obesity. PG - 105002 LID - S0026-2862(26)00102-0 [pii] LID - 10.1016/j.mvr.2026.105002 [doi] AB - PURPOSE: To evaluate retinochoroidal microvascular changes and their association with biochemical parameters in children with obesity. METHODS: This cross-sectional study included 100 children aged 6-15 years (50 obese, 50 normal weight). Retinal parameters superficial and deep capillary plexuses (SCP, DCP), choriocapillaris (CC), foveal avascular zone (FAZ), ganglion cell layer (GCL), and retinal nerve fiber layer (RNFL) were assessed using OCT and OCTA. Biochemical measures, including HDL, LDL, triglycerides, glucose, insulin, and blood pressure, were recorded. Associations between vascular density and biochemical variables were analyzed using regression analysis. RESULTS: Obese children showed a significantly smaller FAZ area than controls (262.11 +/- 60.33 mum(2) vs 316.47 +/- 67.09 mum(2), p < 0.001). RNFL thickness was significantly reduced in the central region (9.35 +/- 5.51 mum vs 11.25 +/- 4.65 mum, p = 0.041). GCL thickness was significantly lower in the temporal (81.55 +/- 10.07 mum vs 87.42 +/- 9.81 mum, p = 0.022) and inferior regions (85.73 +/- 13.29 mum vs 92.69 +/- 10.06 mum, p = 0.028). No significant differences were observed in SCP, DCP, or CC vessel densities. Foveal SCP and DCP vessel densities were negatively associated with systolic blood pressure and positively associated with HDL cholesterol. CONCLUSIONS: Childhood obesity is associated with FAZ reduction and thinning of retinal neural layers. Retinal microvascular findings may reflect the influence of vascular and metabolic risk factors in pediatric obesity. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Bahar, Tevfik Serhat AU - Bahar TS AD - Department of Ophthalmology, Faculty of Medicine, Alanya Alaaddin Keykubat University, Antalya, 07425, Turkey. Electronic address: drserhatbahar@gmail.com. FAU - Bahar, Yasemin Funda AU - Bahar YF AD - Department of Pediatric Endocrinology, Faculty of Medicine, Akdeniz University, Antalya, 07070, Turkey. Electronic address: yaseminfkorkmaz@gmail.com. FAU - Ocal, Olgar AU - Ocal O AD - Department of Ophthalmology, Faculty of Medicine, Akdeniz University, Antalya, 07070, Turkey. Electronic address: ocalolgar@gmail.com. FAU - Cetin, Kursat AU - Cetin K AD - Department of Pediatric Endocrinology, Faculty of Medicine, Akdeniz University, Antalya, 07070, Turkey. Electronic address: kursat5712@gmail.com. FAU - Kayis, Turgut AU - Kayis T AD - Department of Ophthalmology, Faculty of Medicine, Akdeniz University, Antalya, 07070, Turkey. Electronic address: ratumim231@gmail.com. FAU - Tuhan, Hale AU - Tuhan H AD - Department of Pediatric Endocrinology, Faculty of Medicine, Akdeniz University, Antalya, 07070, Turkey. Electronic address: halenvr@hotmail.com. FAU - Yaprak, Asli Cetinkaya AU - Yaprak AC AD - Department of Ophthalmology, Faculty of Medicine, Akdeniz University, Antalya, 07070, Turkey. Electronic address: aslickaya@yahoo.com. FAU - Parlak, Mesut AU - Parlak M AD - Department of Pediatric Endocrinology, Faculty of Medicine, Akdeniz University, Antalya, 07070, Turkey. Electronic address: mesut.parlak@akdeniz.edu.tr. LA - eng PT - Journal Article DEP - 20260814 PL - United States TA - Microvasc Res JT - Microvascular research JID - 0165035 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Child MH - Cross-Sectional Studies MH - Female MH - Male MH - Biomarkers/blood MH - Adolescent MH - *Retinal Vessels/diagnostic imaging/physiopathology/pathology MH - *Tomography, Optical Coherence MH - *Pediatric Obesity/diagnosis/blood/complications/physiopathology MH - Case-Control Studies MH - *Choroid/blood supply MH - *Microcirculation MH - Age Factors MH - Blood Glucose MH - Risk Factors MH - Predictive Value of Tests MH - *Retinal Diseases/etiology/physiopathology/diagnostic imaging/blood/pathology OTO - NOTNLM OT - Biochemical markers OT - Childhood obesity OT - Optical coherence tomography angiography OT - Retinochoroidal microvasculature COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/14 23:37 MHDA- 2026/09/09 23:36 CRDT- 2026/08/14 19:20 PHST- 2026/05/04 00:00 [received] PHST- 2026/08/13 00:00 [revised] PHST- 2026/08/13 00:00 [accepted] PHST- 2026/09/09 23:36 [medline] PHST- 2026/08/14 23:37 [pubmed] PHST- 2026/08/14 19:20 [entrez] AID - S0026-2862(26)00102-0 [pii] AID - 10.1016/j.mvr.2026.105002 [doi] PST - ppublish SO - Microvasc Res. 2026 Nov;168:105002. doi: 10.1016/j.mvr.2026.105002. Epub 2026 Aug 14. PMID- 42600340 OWN - NLM STAT- MEDLINE DCOM- 20260831 LR - 20260831 IS - 1532-3099 (Electronic) IS - 0266-6138 (Linking) VI - 162 DP - 2026 Nov TI - The effect of psychological flexibility level and pregnancy stress on traumatic birth perception and breastfeeding success in primiparous pregnant women in the latent phase. PG - 104937 LID - S0266-6138(26)00241-X [pii] LID - 10.1016/j.midw.2026.104937 [doi] AB - BACKGROUND: Pregnancy and childbirth are significant life events that can affect women's mental health and maternal functioning. Psychological flexibility, defined as the ability to adapt to changing situations and maintain balance under stress, plays a crucial role in this process. This study aimed to examine the effects of psychological flexibility and pregnancy stress on the perception of traumatic birth and breastfeeding success among primiparous pregnant women in the latent phase. METHODS: This cross-sectional study was carried out between January 2021 and June 2022 at a training and research hospital in eastern Turkiye. The study sample consisted of 310 primiparous pregnant women, selected through simple random sampling among eligible participants admitted in the latent phase of labor. Data were collected using the Personal Information Form, Psychological Flexibility Scale, Pregnancy Stress Rating Scale, Traumatic Birth Perception Scale, and LATCH Breastfeeding Assessment Tool. Data were analyzed using descriptive statistics, Pearson correlation analysis, and path analysis based on structural equation modeling (SEM). RESULTS: The study found a significant negative correlation between psychological flexibility and traumatic birth perception (r = -.183, p < .001) and was positively correlated with breastfeeding success (r = .208, p < .001). Pregnancy stress was positively correlated with the perception of traumatic birth (r = .472, p < .001) and negatively correlated with breastfeeding success (r = -.263, p < .001). Path analysis demonstrated that psychological flexibility had a significant negative effect on traumatic birth perception (beta = -.159, p = .001) and a significant positive effect on breastfeeding success (beta = .214, p < .001). Pregnancy stress had a significant positive effect on traumatic birth perception (beta = .468, p < .001) and a significant negative effect on breastfeeding success (beta = -.257, p < .001). CONCLUSION: Increased psychological flexibility was associated with a lower perception of traumatic birth and higher breastfeeding success. Conversely, higher pregnancy stress was linked to higher traumatic birth perception and lower breastfeeding success. These findings highlight the importance of integrating psychological flexibility-based interventions into prenatal education and midwifery care to promote maternal mental health and breastfeeding outcomes. In addition, future studies could explore intervention programs designed to enhance psychological flexibility among pregnant women to prevent traumatic birth experiences and improve postpartum adaptation. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Gezer Tekdal, Aysegul AU - Gezer Tekdal A AD - Adiyaman University, Faculty of Health Sciences, Department of Midwifery, Altinsehir, Ataturk Blv. No: 1, Adiyaman, 02040 , Turkiye. Electronic address: atekdal@adiyaman.edu.tr. FAU - Unver Koca, Hacer AU - Unver Koca H AD - Department of Midwifery, Faculty of Health Sciences, Inonu University, Malatya, Turkiye. Electronic address: hacer.unver@inonu.edu.tr. LA - eng PT - Journal Article DEP - 20260806 PL - Scotland TA - Midwifery JT - Midwifery JID - 8510930 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adult MH - Cross-Sectional Studies MH - *Breast Feeding/psychology/statistics & numerical data MH - *Stress, Psychological/psychology/complications MH - *Pregnant People/psychology MH - Psychometrics/instrumentation/methods MH - Surveys and Questionnaires MH - Turkey MH - *Perception MH - Parity MH - *Parturition/psychology MH - Adaptation, Psychological MH - Cognitive Flexibility OTO - NOTNLM OT - Breastfeeding OT - Prenatal stress OT - Primiparity OT - Psychological flexibility OT - Traumatic childbirth COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/14 23:37 MHDA- 2026/08/31 23:43 CRDT- 2026/08/14 18:05 PHST- 2026/02/15 00:00 [received] PHST- 2026/08/04 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/31 23:43 [medline] PHST- 2026/08/14 23:37 [pubmed] PHST- 2026/08/14 18:05 [entrez] AID - S0266-6138(26)00241-X [pii] AID - 10.1016/j.midw.2026.104937 [doi] PST - ppublish SO - Midwifery. 2026 Nov;162:104937. doi: 10.1016/j.midw.2026.104937. Epub 2026 Aug 6. PMID- 42600329 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260907 IS - 1873-1600 (Electronic) IS - 1466-853X (Linking) VI - 81 DP - 2026 Sep TI - Diagnostic accuracy of patient history and clinical examination to identify pathology in the lumbar spine of elite gymnasts with MRI as the reference standard. PG - 101970 LID - S1466-853X(26)00091-X [pii] LID - 10.1016/j.ptsp.2026.101970 [doi] AB - OBJECTIVE: To evaluate the diagnostic accuracy of patient history and physical examination for diagnosing common causes of low back pain in elite gymnasts, using MRI as the reference standard. DESIGN: Prospective cross-sectional study reported according to STARD guidelines. Index tests were acquired by an experienced musculoskeletal physiotherapist blinded to imaging. MRI scans were independently analysed by two specialist musculoskeletal radiologists. SETTING: MRI centre, Birmingham, UK. PARTICIPANTS: Non-probability consecutive total-population sample of elite gymnasts, regardless of low back pain status. MAIN OUTCOME MEASURES: Sensitivity and specificity of individual index tests and exploratory test clusters. RESULTS: Forty participants consented; 75% had abnormal MRI findings. Most specific findings were 'eased by flexion' and 'erector spinae hypertrophy' for degenerative disc disease, 'erector spinae hypertrophy', 'pain on flexion in standing', and 'pain on extension/left side flexion' for disc herniation, 'pain on flexion in standing' plus 'pain on extension/left side flexion' for pars oedema/spondylolysis; and 'eased by flexion' with the same cluster for spondylolisthesis. CONCLUSIONS: Highly specific index tests and exploratory clusters showed diagnostic accuracy for identifying gymnasts without degenerative disc disease, disc herniation, and pars oedema/spondylolysis. All gymnasts were recruited regardless of low back pain; these findings need to be considered cautiously when applied clinically. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Fawcett, Louise AU - Fawcett L AD - Head of Olympic Performance Support, UK Sports Institute, Lilleshall National Sports Centre, Nr Newport, Shropshire, TF10 9AT, UK; School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, West Midlands, UK. Electronic address: LXF615@student.bham.ac.uk. FAU - Martin, James AU - Martin J AD - Biostatistics, Department of Applied Health Sciences, University of Birmingham, West Midlands, UK. FAU - James, Steven AU - James S AD - School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, West Midlands, UK; Consultant Musculoskeletal Radiologist, Department of Radiology, Royal Orthopaedic Hospital, Birmingham, UK. FAU - Soundy, Andrew AU - Soundy A AD - Physiotherapy, School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, West Midlands, UK. FAU - Heneghan, Nicola R AU - Heneghan NR AD - School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, West Midlands, UK. FAU - Rushton, Alison AU - Rushton A AD - School of Physical Therapy, Western University, London, Canada; Centre of Precision Rehabilitation for Spinal Pain, School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, West Midlands, UK. LA - eng PT - Journal Article DEP - 20260806 PL - England TA - Phys Ther Sport JT - Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine JID - 100940513 SB - IM MH - Humans MH - *Magnetic Resonance Imaging MH - Cross-Sectional Studies MH - Female MH - *Gymnastics/injuries MH - *Lumbar Vertebrae/pathology/diagnostic imaging MH - *Low Back Pain/diagnosis/etiology/diagnostic imaging MH - Prospective Studies MH - Male MH - *Physical Examination MH - Adolescent MH - Young Adult MH - Adult MH - Sensitivity and Specificity MH - *Medical History Taking MH - Reference Standards MH - Intervertebral Disc Degeneration/diagnosis OTO - NOTNLM OT - Diagnostic accuracy OT - Gymnastics OT - Low back pain OT - MRI COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Louise Fawcett reports financial support was provided by British Society of Skeletal Radiologists. Louise Fawcett reports financial support was provided by Musculoskeletal Association of Chartered Physiotherapists. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/14 23:37 MHDA- 2026/09/07 23:34 CRDT- 2026/08/14 18:04 PHST- 2026/05/07 00:00 [received] PHST- 2026/07/26 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/09/07 23:34 [medline] PHST- 2026/08/14 23:37 [pubmed] PHST- 2026/08/14 18:04 [entrez] AID - S1466-853X(26)00091-X [pii] AID - 10.1016/j.ptsp.2026.101970 [doi] PST - ppublish SO - Phys Ther Sport. 2026 Sep;81:101970. doi: 10.1016/j.ptsp.2026.101970. Epub 2026 Aug 6. PMID- 42600070 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260814 LR - 20260816 IS - 2291-9279 (Print) IS - 2291-9279 (Electronic) VI - 14 DP - 2026 Aug 14 TI - Structured Virtual Reality Exergame Intervention in Adolescents With Mild Intellectual Disabilities: Pre-Post Pilot Study on Motor Proficiency and Reaction Time. PG - e95572 LID - 10.2196/95572 [doi] LID - e95572 AB - BACKGROUND: Adolescents with mild intellectual disabilities often exhibit deficits in motor proficiency and neurocognitive processing, which can limit their functional independence. Although virtual reality (VR) exergames provide a motivating platform for physical activity, objective data quantifying their impact on standardized motor scales remain scarce, particularly when implemented through structured pedagogical frameworks. Earlier research established the WISH (warm-up, imitation, settings, half-hour) and WON (warm-up, objective evaluation, no problem!) protocols to facilitate gameplay independence in this population. However, the extent to which this systematic approach translates into measurable clinical motor and reaction time gains requires further investigation. OBJECTIVE: This study evaluated the effectiveness of a 16-session structured VR exergame intervention, using the WISH and WON protocols, in enhancing motor proficiency and shortening simple reaction time among adolescents with mild intellectual disability. METHODS: A multisession, single-group pretest and posttest pilot design was used. A convenience sample of 8 adolescents (3 males, 5 females; mean age 17.63, SD 1.77, range 15-20 years) was recruited from a special school complex in Poland. The intervention was conducted over an 8-month period (October 2023 to May 2024), consisting of 16 sessions conducted once every 2 weeks. The rhythmic fitness game "OhShape!" (Odders Lab) was played on the Meta Quest 2 system. Motor proficiency was assessed with the Bruininks-Oseretsky Test of Motor Proficiency short form, and simple reaction time to visual and auditory stimuli was measured using a standardized Alfa-Electronics meter. Statistical analysis was performed using the Wilcoxon signed-rank test (alpha=.05). RESULTS: Total Bruininks-Oseretsky Test of Motor Proficiency scores significantly improved from a baseline mean of 69.25 (SD 6.80; 95% CI 63.56-74.94) to 80.50 (SD 5.50; 95% CI 75.90-85.10) at the posttest (P=.01; r=0.74). Based on the standardized 5-point proficiency scale, the group mean rose from 1.88 (SD .64; 95% CI 1.34-2.42) at baseline to 2.88 (SD .35; 95% CI 2.59-3.17) postintervention (P=.008; r=0.89). Furthermore, the mean simple reaction time decreased from 426.50 (SD 52.3; 95% CI 382.78-470.22) ms to 392.10 (SD 38.4; 95% CI 359.98-424.22) ms at the final assessment (P=.02; r=0.72). CONCLUSIONS: This pilot study suggests structured VR exergaming may address motor deficits in adolescents with mild intellectual disability. Promoting autonomy via protocols was associated with measurable motor gains within this cohort. Although the absence of a control group limits causal claims, immersive VR may offer a supportive tool for neuro-motor adaptations in special education, warranting validation in larger controlled trials. CI - (c) Julia Ciazynska, Agnieszka Kazimiera Rudowicz, Aneta Worska, Janusz Maciaszek. Originally published in JMIR Serious Games (https://games.jmir.org). FAU - Ciazynska, Julia AU - Ciazynska J AUID- ORCID: 0000-0001-9065-9164 AD - Department of Physical Activity and Health Promotion Science, Poznan University of Physical Education, Krolowej Jadwigi 27/39, Poznan, Poland, 48 (61) 835 50 07. FAU - Rudowicz, Agnieszka Kazimiera AU - Rudowicz AK AUID- ORCID: 0009-0002-3009-0046 AD - Special School Complex No. 102, Poznan, Poland. FAU - Worska, Aneta AU - Worska A AUID- ORCID: 0000-0003-1624-5267 AD - Department of Physical Activity and Health Promotion Science, Poznan University of Physical Education, Krolowej Jadwigi 27/39, Poznan, Poland, 48 (61) 835 50 07. FAU - Maciaszek, Janusz AU - Maciaszek J AUID- ORCID: 0000-0001-8425-5921 AD - Department of Physical Activity and Health Promotion Science, Poznan University of Physical Education, Krolowej Jadwigi 27/39, Poznan, Poland, 48 (61) 835 50 07. LA - eng PT - Journal Article DEP - 20260814 PL - Canada TA - JMIR Serious Games JT - JMIR serious games JID - 101645255 PMC - PMC13475785 OTO - NOTNLM OT - active video game OT - bilateral coordination OT - exergame OT - gross motor movements OT - health promotion OT - intellectual disabilities OT - physical activity OT - physical education OT - postural stability OT - virtual reality COIS- Conflicts of Interest: None declared. EDAT- 2026/08/14 17:39 MHDA- 2026/08/14 17:40 PMCR- 2026/08/14 CRDT- 2026/08/14 15:03 PHST- 2026/03/17 00:00 [received] PHST- 2026/07/03 00:00 [revised] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/08/14 17:40 [medline] PHST- 2026/08/14 17:39 [pubmed] PHST- 2026/08/14 15:03 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - v14i1e95572 [pii] AID - 95572 [pii] AID - 10.2196/95572 [doi] PST - epublish SO - JMIR Serious Games. 2026 Aug 14;14:e95572. doi: 10.2196/95572. PMID- 42599780 OWN - NLM STAT- MEDLINE DCOM- 20260814 LR - 20260831 IS - 1680-0745 (Electronic) IS - 1015-9657 (Linking) VI - 37 IP - 3 DP - 2026 Jul 31 TI - Body mass index predicts ventricular repolarisation in obese children: differential effects across obesity levels. PG - 282-292 LID - 10.5830/CVJA-2026-029 [doi] AB - BACKGROUND: Childhood obesity is associated with cardiac electrical remodelling, yet the relationship between body mass index (BMI) and ventricular repolarisation (VR) heterogeneity remains incompletely characterised in paediatric obesity. METHODS: This prospective observational comparative study enrolled 184 children (112 obese, 72 normal-weight; age 8-17 years). Electrocardiographic analysis included traditional (QT, QTc, JT) and novel VR parameters (Tp-e interval, Tp-e/QT, Tp-e/QTc ratios). Multiple linear regression and receiver operating characteristic (ROC) analyses identified independent predictors and clinically applicable thresholds. RESULTS: Obese children demonstrated significantly prolonged Tp-e intervals (87.83 +/- 12.35 vs. 80.10 +/- 16.80 ms, p = 0.002) and elevated Tp-e/QTcB ratios (0.211 +/- 0.028 vs. 0.192 +/- 0.034, p < 0.001). BMI emerged as the independent predictor of VR heterogeneity (beta = 0.308, p < 0.001), after adjustment for insulin resistance, metabolic parameters, and echocardiographic findings. Regression analyses revealed differences in the BMI-repolarisation relationship: strong associations in normal-weight children (beta = 0.353, p = 0.003), disappearing in established obesity (beta = -0.041, p = 0.699), and a significant BMI x group interaction was observed (beta = -2.079, p = 0.001). ROC analysis identified BMI >/= 23.1 kg/m(2) as the optimal threshold for abnormal repolarisation (AUC = 0.682, sensitivity 76.1%, specificity 50.0%, p < 0.001). CONCLUSION: Childhood obesity is associated with VR abnormalities independently of metabolic dysfunction and structural cardiac changes. This study suggests that repolarisation abnormalities occur in the early stages of obesity and through different pathophysiological mechanisms. The defined BMI threshold provides a clinically applicable tool for early risk stratification, highlighting the critical importance of intervention before obesity becomes established. FAU - Karayakali, Metin AU - Karayakali M AD - Department of Cardiology, Tokat Gaziosmanpasa University, Tokat, Turkey. Email: drmk5170@gmail.com. FAU - Karaman, Kayihan AU - Karaman K AD - Department of Cardiology, Tokat Gaziosmanpasa University, Tokat, Turkey. FAU - Kasap, Tuba AU - Kasap T AD - Department of Pediatric Clinics, Tokat Gaziosmanpasa University, Tokat, Turkey. FAU - Yilmaz, Volkan AU - Yilmaz V AD - Department of Cardiology, Tokat Gaziosmanpasa University, Tokat, Turkey. LA - eng PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20260731 PL - South Africa TA - Cardiovasc J Afr JT - Cardiovascular journal of Africa JID - 101313864 SB - IM MH - Humans MH - Child MH - *Body Mass Index MH - Male MH - Female MH - Prospective Studies MH - Adolescent MH - *Pediatric Obesity/diagnosis/physiopathology/complications MH - Electrocardiography MH - *Action Potentials MH - Predictive Value of Tests MH - *Arrhythmias, Cardiac/physiopathology/etiology/diagnosis MH - *Heart Rate MH - Age Factors MH - Risk Factors MH - *Heart Conduction System/physiopathology MH - Adiposity MH - *Ventricular Remodeling MH - Risk Assessment OTO - NOTNLM OT - arrhythmia OT - body mass index OT - electrocardiogram OT - repolarisation EDAT- 2026/08/14 17:39 MHDA- 2026/08/14 17:40 CRDT- 2026/08/14 12:22 PHST- 2025/12/14 00:00 [received] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/08/14 17:40 [medline] PHST- 2026/08/14 17:39 [pubmed] PHST- 2026/08/14 12:22 [entrez] AID - 10.5830/CVJA-2026-029 [doi] PST - ppublish SO - Cardiovasc J Afr. 2026 Jul 31;37(3):282-292. doi: 10.5830/CVJA-2026-029. Epub 2026 Jul 31. PMID- 42598624 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260814 LR - 20260926 IS - 0976-5662 (Print) IS - 2213-3445 (Electronic) IS - 0976-5662 (Linking) VI - 82 DP - 2026 Nov TI - Direct anterior approach for open correction of Slipped Capital Femoral Epiphysiolysis: surgical technique and clinical outcome. PG - 103572 LID - 10.1016/j.jcot.2026.103572 [doi] LID - 103572 AB - BACKGROUND: Slipped Capital Femoral Epiphysis (SCFE) is an idiopathic hip disorder in adolescents. With or without surgery, avascular necrosis (AVN) is the most dangerous complication. For open reduction and internal fixation, the modified Dunn procedure is considered the gold standard. This study presents an open epiphyseal realignment through the Hueter-interval and reports on (1) surgical technique of direct anterior approach (DAA) based surgical realignment, (2) radiographic correction of biomechanics, and (3) AVN-incidence after surgery. METHODS: A single-center retrospective case series was conducted including all patients who underwent open realignment for SCFE via the direct anterior approach between January 2014 and January 2025. Pre- and postoperative Southwick and alpha angles were measured by two independent observers. Complications, including avascular necrosis, chondrolysis, and degenerative changes, were assessed at final follow-up. Descriptive statistics were used. Interobserver agreement of radiographic measurements was assessed using the intraclass correlation coefficient (ICC). RESULTS: Twelve patients (13 hips; 9 boys and 3 girls) were included. Median age and BMI were respectively 12.9 years old (IQR 12.2-13.7) and 23.1 kg/m(2) (IQR 19.9-29.5) kg/m(2). One patient showed bilateral involvement. Median preoperative AP - and lateral Southwick angle were respectively 117.5 (IQR 95.8-137.3) and 59.6 (IQR 35.1-71.8) degrees. After open realignment, median postoperative AP - and lateral Southwick angles were respectively 139.5 (IQR 135.0-143.3) and 14.7 (IQR 11.3-20.9). Thus, a correction of the lateral Southwick angle of 31.2 (IQR 17.4-54.2) was achieved. Follow-up was 6.0 years (IQR 2.4-8.3) and none of the patients developed AVN. Median Alpha-angle on Dunn view at final follow-up was 44.5 (IQR 42.8-68.1). CONCLUSION: The DAA described in this series, can be considered a reproducible technique for an open realignment of displaced SCFE. None of the cases had an AVN and the approach does not appear to limit correction potential. LEVEL OF EVIDENCE: Level 4 Therapeutic study. CI - (c) 2026 The Authors. FAU - Vandeputte, Frans-Jozef AU - Vandeputte FJ AD - Department of Orthopedic Surgery and Traumatology, Ziekenhuis Oost Limburg (ZOL) Genk, Synaps Park 1, 3600, Genk, Belgium. AD - European Hip Center, Boskant 18, 2260, Westerlo, Belgium. AD - Faculty of Medicine and Life Sciences, Hasselt University, Diepenbeek, Belgium. FAU - Clarebout, Siebe AU - Clarebout S AD - Department of Orthopedic Surgery and Traumatology, Ziekenhuis Oost Limburg (ZOL) Genk, Synaps Park 1, 3600, Genk, Belgium. FAU - Sergooris, Abner AU - Sergooris A AD - European Hip Center, Boskant 18, 2260, Westerlo, Belgium. AD - REVAL, Rehabilitation Research, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium. FAU - Gevers, Mathieu AU - Gevers M AD - Department of Orthopedic Surgery and Traumatology, Ziekenhuis Oost Limburg (ZOL) Genk, Synaps Park 1, 3600, Genk, Belgium. FAU - Van Praet, Frank AU - Van Praet F AD - Department of Orthopedic Surgery and Traumatology, Ziekenhuis Oost Limburg (ZOL) Genk, Synaps Park 1, 3600, Genk, Belgium. FAU - Corten, Kristoff AU - Corten K AD - Department of Orthopedic Surgery and Traumatology, Ziekenhuis Oost Limburg (ZOL) Genk, Synaps Park 1, 3600, Genk, Belgium. AD - European Hip Center, Boskant 18, 2260, Westerlo, Belgium. AD - REVAL, Rehabilitation Research, Faculty of Rehabilitation Sciences, Hasselt University, Diepenbeek, Belgium. LA - eng PT - Journal Article DEP - 20260720 PL - India TA - J Clin Orthop Trauma JT - Journal of clinical orthopaedics and trauma JID - 101559469 PMC - PMC13472028 OTO - NOTNLM OT - Direct anterior approach OT - SCFE OT - Slipped capital femoral Epiphyses COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/14 12:16 MHDA- 2026/08/14 12:17 PMCR- 2026/07/20 CRDT- 2026/08/14 08:03 PHST- 2026/04/15 00:00 [received] PHST- 2026/06/27 00:00 [revised] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/08/14 12:17 [medline] PHST- 2026/08/14 12:16 [pubmed] PHST- 2026/08/14 08:03 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - S0976-5662(26)00240-7 [pii] AID - 103572 [pii] AID - 10.1016/j.jcot.2026.103572 [doi] PST - epublish SO - J Clin Orthop Trauma. 2026 Jul 20;82:103572. doi: 10.1016/j.jcot.2026.103572. eCollection 2026 Nov. PMID- 42598598 OWN - NLM STAT- MEDLINE DCOM- 20260814 LR - 20260817 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Effects of physical activity distribution patterns on basketball skill acquisition and physical exercise self-efficacy among Chinese male university students: a randomised controlled trial. PG - e21459 LID - 10.7717/peerj.21459 [doi] LID - e21459 AB - BACKGROUND: As an open-skills sport, basketball not only enhances university students' physical fitness and specialised techniques but also influences their technical learning efficiency and exercise self-efficacy through patterns of physical activity distribution. However, empirical research on the mechanisms underlying the effects of physical activity distribution patterns on basketball technical performance and self-efficacy remains limited. OBJECTIVE: This study aims to investigate the impact of two distinct physical activity patterns (massed vs. regularly distributed) on specialised basketball skill acquisition and exercise self-efficacy among Chinese male university students. METHOD: A randomised controlled trial design was employed, enrolling 105 male university students aged 18-25 years. The participants were randomly assigned to either a massed training group or a regularly distributed training group. Both interventions lasted 8 weeks, followed by a 2-month follow-up period. Training volume and intensity were maintained at equivalent levels, differing solely in the distribution of practice sessions. Basketball skill acquisition was assessed through shooting accuracy, dribbling agility, and passing precision, whereas psychological efficacy was measured via the Revised Self-Efficacy Scale for Physical Exercise. Generalised estimating equation (GEE) and simple effects analyses were employed to examine between-group and within-group differences, controlling for potential confounding factors. RESULTS: The findings indicate that the regularly distributed training group demonstrated significantly greater improvements than did the massed training group in shooting (odds ratio (OR) = 2.316, P < 0.001), passing (OR = 1.608, P < 0.001), and self-efficacy (OR = 2.691, P = 0.001), with partial effects persisting two months post-intervention. Both groups demonstrated improvements in dribbling performance, although the differences between groups were not statistically significant. CONCLUSION: A regularly distributed physical activity pattern has greater advantages in promoting basketball-specific skills (particularly shooting and passing) and physical exercise self-efficacy. This suggests that basketball training programmes should prioritise optimising practice distribution to increase skill acquisition quality and sustain long-term exercise motivation. Future research may extend to different gender and age groups while incorporating game performance metrics to further validate the efficacy of distributed practice. CI - (c)2026 Liu et al. FAU - Liu, Zhuoxiao AU - Liu Z AD - Strength and Conditioning Training College, Beijing Sports University, Haidian, Beijing, China. AD - School of Physical Education, Shanghai University of Sport, Yangpu, Shanghai, China. FAU - Zhou, Chengyu AU - Zhou C AD - Strength and Conditioning Training College, Beijing Sports University, Haidian, Beijing, China. AD - School of Physical Education, Shanghai University of Sport, Yangpu, Shanghai, China. FAU - Zeng, Zhuo AU - Zeng Z AD - Strength and Conditioning Training College, Beijing Sports University, Haidian, Beijing, China. FAU - Yang, Huaibo AU - Yang H AD - Department of Physical Education, Hongshan College of Nanjing University of Finance and Economics, Nanjing, Jiangsu, China. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260810 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 RN - Chinese people SB - IM MH - Humans MH - Male MH - *Basketball/psychology MH - *Self Efficacy MH - Young Adult MH - Adult MH - Adolescent MH - *Exercise/psychology MH - Universities MH - *Students/psychology MH - China MH - *Athletic Performance MH - East Asian People PMC - PMC13471745 OTO - NOTNLM OT - Basketball OT - Distributed practice OT - Physical activity patterns OT - Physical exercise self-efficacy OT - Technical performance COIS- The authors declare there are no competing interests. EDAT- 2026/08/14 12:16 MHDA- 2026/08/14 12:17 PMCR- 2026/08/10 CRDT- 2026/08/14 08:02 PHST- 2025/11/24 00:00 [received] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/08/14 12:17 [medline] PHST- 2026/08/14 12:16 [pubmed] PHST- 2026/08/14 08:02 [entrez] PHST- 2026/08/10 00:00 [pmc-release] AID - 21459 [pii] AID - 10.7717/peerj.21459 [doi] PST - epublish SO - PeerJ. 2026 Aug 10;14:e21459. doi: 10.7717/peerj.21459. eCollection 2026. PMID- 42597527 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260814 LR - 20260815 IS - 2296-875X (Print) IS - 2296-875X (Electronic) IS - 2296-875X (Linking) VI - 13 DP - 2026 TI - Development of an automated machine learning-based risk prediction and decision support system for postoperative cubitus varus complicating pediatric lateral humeral condyle fracture. PG - 1836372 LID - 10.3389/fsurg.2026.1836372 [doi] LID - 1836372 AB - PURPOSE: Postoperative cubitus varus is a disabling complication of pediatric lateral humeral condyle fractures that impairs long-term elbow function. This study aimed to develop and validate the first Improved LangEvin Equation-based Evolutionary (ILEE) automated machine learning (AutoML) model and visual decision support system for preoperative prediction of this complication, to enable personalized risk stratification and targeted intervention. METHODS: We conducted a retrospective cohort study of 330 children with lateral humeral condyle fractures treated between January 2005 and June 2022. An ILEE-optimized AutoML model was constructed and compared with the original LEE algorithm and 6 conventional machine learning models. Model performance was evaluated using area under the receiver operating characteristic curve (ROC-AUC), accuracy, sensitivity, and specificity. Key predictors were identified and interpreted via SHapley Additive exPlanations (SHAP) analysis, and a clinical decision support system was developed using MATLAB App Designer. RESULTS: The ILEE algorithm outperformed all comparators in optimization stability and convergence speed. The AutoML model identified five key features for predicting cubitus varus and exhibited better prediction calibration performance compared to other models (ROC-AUC = 0.9557). SHAP analysis ranked the importance of these features as follows: obesity degree, preoperative timing, internal fixation time, fracture type, and external fixation time. The decision support system can generate real-time risk levels, predicted probabilities, and personalized clinical recommendations within 1 s. CONCLUSION: This study establishes the first ILEE-based AutoML model for predicting postoperative cubitus varus in pediatric lateral humeral condyle fractures, demonstrating competitive predictive performance. The user-friendly visual system enables rapid preoperative risk assessment, assisting clinicians in identify high-risk patients, optimize treatment plans, and potentially improving pediatric orthopedic outcomes. CI - (c) 2026 Wan, Deng, Yuan, Zhang, Li, Cai and Wang. FAU - Wan, Yu AU - Wan Y AD - Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Deng, Kun AU - Deng K AD - Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Yuan, Yang AU - Yuan Y AD - Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhang, Li AU - Zhang L AD - Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Li, Cong AU - Li C AD - Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Cai, Haoqi AU - Cai H AD - Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Wang, Yufeng AU - Wang Y AD - Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. LA - eng PT - Journal Article DEP - 20260730 PL - Switzerland TA - Front Surg JT - Frontiers in surgery JID - 101645127 PMC - PMC13469642 OTO - NOTNLM OT - automated machine learning OT - clinical decision support system OT - cubitus varus OT - improved langEvin equation-based evolutionary OT - lateral humeral condyle fracture COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/14 12:16 MHDA- 2026/08/14 12:17 PMCR- 2026/07/30 CRDT- 2026/08/14 06:27 PHST- 2026/03/22 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/08/14 12:17 [medline] PHST- 2026/08/14 12:16 [pubmed] PHST- 2026/08/14 06:27 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - 10.3389/fsurg.2026.1836372 [doi] PST - epublish SO - Front Surg. 2026 Jul 30;13:1836372. doi: 10.3389/fsurg.2026.1836372. eCollection 2026. PMID- 42597189 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260814 LR - 20260815 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 13 DP - 2026 TI - Microbiota-gut-brain axis in cerebral palsy: from mechanisms to interventions. PG - 1911417 LID - 10.3389/fmed.2026.1911417 [doi] LID - 1911417 AB - Cerebral palsy (CP) is the most common cause of chronic motor disability in childhood and arises from non-progressive injury to the developing brain. Despite the static nature of the primary lesion, children with CP frequently experience evolving gastrointestinal, nutritional, inflammatory, sleep, cognitive, and seizure-related comorbidities that substantially influence functional recovery and caregiver burden. The microbiota-gut-brain axis (MGBA) provides a biologically plausible framework linking these multisystem manifestations. Emerging evidence suggests that children with CP may exhibit reduced gut microbial diversity, depletion of short-chain fatty acid (SCFA)-producing taxa, enrichment of opportunistic bacteria, and microbiome remodeling related to diet, constipation, antiepileptic drug exposure, oral inflammation, and care patterns. Dysbiosis may interact with CP through epithelial barrier disruption, lipopolysaccharide translocation, systemic immune activation, altered tryptophan-kynurenine metabolism, abnormal bile acid and SCFA signaling, vagal and enteric nervous system pathways, hypothalamic-pituitary-adrenal axis dysregulation, and microglial priming. These mechanisms may create a self-reinforcing cycle in which early brain injury promotes gut dysfunction, gut dysfunction reshapes the microbiome, and dysbiotic immune-metabolic signals further amplify symptom burden. Current interventions, including nutritional optimization, constipation protocols, dietary fiber, probiotics, prebiotics, synbiotics, oral health management, and family-centered care, show promise for improving bowel symptoms and selected microbial or inflammatory indices. However, most clinical studies remain small, short-term, and focused on constipation rather than long-term neurodevelopmental outcomes. All CP-specific human evidence currently demonstrates association rather than causation; no study has established that dysbiosis initiates CP or causally drives its neurological phenotype. Accordingly, mechanistic pathways are presented as testable hypotheses, not validated causal mechanisms in CP. This review synthesizes current evidence on the MGBA in CP, outlines mechanistic pathways, evaluates therapeutic opportunities, and proposes future directions for biomarker-driven and stratified intervention trials. CI - Copyright (c) 2026 Xie, Bai, Xu and Luan. FAU - Xie, Fei AU - Xie F AD - Department of Neurosurgery, The Seventh Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China. FAU - Bai, Chao AU - Bai C AD - Cerebral Palsy Center in Neurosurgery, Second Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China. FAU - Xu, Jian AU - Xu J AD - Department of Neurosurgery, The Seventh Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China. FAU - Luan, Xinping AU - Luan X AD - Cerebral Palsy Center in Neurosurgery, Second Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China. LA - eng PT - Journal Article PT - Review DEP - 20260730 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC13467827 OTO - NOTNLM OT - cerebral palsy OT - constipation OT - gut microbiota OT - microbiota-gut-brain axis OT - neuroinflammation OT - nutritional intervention OT - probiotics COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/14 12:16 MHDA- 2026/08/14 12:17 PMCR- 2026/07/30 CRDT- 2026/08/14 05:32 PHST- 2026/06/17 00:00 [received] PHST- 2026/07/14 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/08/14 12:17 [medline] PHST- 2026/08/14 12:16 [pubmed] PHST- 2026/08/14 05:32 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - 10.3389/fmed.2026.1911417 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Jul 30;13:1911417. doi: 10.3389/fmed.2026.1911417. eCollection 2026. PMID- 42596884 OWN - NLM STAT- MEDLINE DCOM- 20260814 LR - 20260816 IS - 2047-2986 (Electronic) IS - 2047-2978 (Print) IS - 2047-2978 (Linking) VI - 16 DP - 2026 Aug 14 TI - DNA methylation informs adult cardiovascular risk and prevention for low birthweight individuals. PG - 04242 LID - 10.7189/jogh.16.04242 [doi] LID - 04242 AB - BACKGROUND: Barker's hypothesis posits that adverse in utero exposures, often reflected by low birthweight, increase adult cardiovascular disease (CVD) risk. However, underlying mechanisms remain unclear; identifying potentially causal mediators is crucial for developing effective interventions. Emerging research suggests epigenetic modifications may influence CVD traits from early life. We aimed to identify DNA methylation (DNAm) signatures that mediate birthweight and CVD traits and to establish their biological relevance across three developmental time points using multi-omics integration. METHODS: We identified DNAm mediators using epigenetic Mendelian randomisation (MR). The exposures were 261 birthweight-associated CpG sites (BW-CpGs) from epigenome-wide association studies, instrumented by cis-methylation quantitative trait loci (cis-mQTLs) in European-ancestry participants from the Accessible Resource for Integrative Epigenomic Studies measured at three developmental time points: birth (mean gestational age = 40 weeks), childhood (mean age = 7.49 years), and adolescence (mean age = 17.14 years). The outcomes included adult cardiovascular events and lipid traits from genome-wide association studies (n = 98,048-547,261). Sensitivity analyses included colocalisation, Steiger's test, Cochran's Q, and pleiotropy-robust methods. We interrogated DNAm persisting across development using omics datasets. RESULTS: Using cis-mQTLs measured at birth, we found 230 associations between 216 BW-CpGs and CVD traits, including coronary artery disease, hypertension, stroke, cholesterol, and triglycerides (false discovery rate-corrected P < 0.05), with effect size directions consistent with Barker's hypothesis. A total of 42 associations were robust following sensitivity analyses. Persistent DNAm changes across development were observed at ASGR1 and KDM2B. Multi-omics interrogation prioritised a promising therapeutic candidate (ASGR1). CONCLUSIONS: Although Barker's hypothesis is well-established, this is the first study to explore its causal pathway using a rigorous, multi-time-point epigenetic MR framework with multi-omic integration. This represents a major advancement over previous observational and DNAm studies. The Barker-consistent hypothesis-free discovery approach identified novel and known candidate genes that, with future validation, may serve as therapeutic targets, identify high-risk individuals, and support clinical trial recruitment. CI - (c) 2026 The Authors. FAU - Tang, John Yen AU - Tang JY FAU - Ng, Nicole Ying Ting AU - Ng NYT FAU - Kwok, Alice Wing Sze AU - Kwok AWS FAU - Mak, Christopher Chun Yu AU - Mak CCY FAU - Cheung, Yiu-Fai AU - Cheung YF FAU - Chung, Brian Hon Yin AU - Chung BHY LA - eng PT - Journal Article DEP - 20260814 PL - Scotland TA - J Glob Health JT - Journal of global health JID - 101578780 SB - IM MH - Humans MH - *DNA Methylation MH - Female MH - *Cardiovascular Diseases/genetics/prevention & control/epidemiology MH - Genome-Wide Association Study MH - *Infant, Low Birth Weight MH - Adolescent MH - Child MH - *Birth Weight/genetics MH - Male MH - Mendelian Randomization Analysis MH - Heart Disease Risk Factors MH - Infant, Newborn MH - Developmental Origins of Health and Disease MH - Epigenesis, Genetic MH - Adult PMC - PMC13474067 OTO - NOTNLM OT - Barker's hypothesis OT - DNA methylation OT - Mendelian randomisation OT - cardiovascular disease risk OT - epigenetics COIS- Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests. EDAT- 2026/08/14 12:16 MHDA- 2026/08/14 12:17 PMCR- 2026/08/14 CRDT- 2026/08/14 05:12 PHST- 2026/08/14 12:17 [medline] PHST- 2026/08/14 12:16 [pubmed] PHST- 2026/08/14 05:12 [entrez] PHST- 2026/08/14 00:00 [pmc-release] AID - jogh-16-04242 [pii] AID - 10.7189/jogh.16.04242 [doi] PST - epublish SO - J Glob Health. 2026 Aug 14;16:04242. doi: 10.7189/jogh.16.04242. PMID- 42595859 OWN - NLM STAT- MEDLINE DCOM- 20260814 LR - 20260912 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 9 DP - 2026 Aug 13 TI - Is watchful waiting an alternative to adenotonsillectomy in children with mild to moderate obstructive sleep apnoea? LID - 10.1007/s00431-026-07330-6 [doi] LID - 663 AB - Adenotonsillectomy (ATE) has traditionally been the first-line treatment for obstructive sleep apnoea (OSA) in children. Increasing evidence suggests that many children with mild to moderate OSA may improve without surgery. This mini-review examines whether watchful waiting is a safe and effective alternative to ATE in otherwise healthy children with mild to moderate OSA. We searched PubMed from inception to January 2026 for randomised controlled trials (RCTs) comparing ATE with watchful waiting in children aged 1-16 years with OSA or sleep-disordered breathing confirmed by polysomnography or a validated symptom score. Two reviewers independently screened and extracted data. Results were analysed qualitatively. Five RCTs (seven published reports; n = 1287 children; mean age 6.1 years) met inclusion criteria. Spontaneous OSA resolution occurred in 44-55% of children managed with watchful waiting, compared with 57-79% following ATE. ATE produced statistically greater reductions in the apnoea-hypopnoea index in four of five trials, but between-group differences were modest. The largest and most consistent effects of ATE were seen for OSA symptom scores. CONCLUSION: Watchful waiting is a reasonable option for young, nonobese children with mild OSA, given the relatively high rates of spontaneous resolution. ATE remains appropriate for children with moderate to severe OSA. Shared decision-making, individualised care and close follow-up are essential when watchful waiting is chosen. WHAT IS KNOWN: * Otherwise healthy children with obstructive sleep apnoea due to adenotonsillar hyperplasia are usually managed with adenotonsillectomy. * Young, non-obese, Caucasian children with more mild obstructive sleep apnoea, however, showed a surprisingly high probability of spontaneous resolution of the disease in one study. WHAT IS NEW: * High rates of spontaneous resolution of obstructive sleep apnoea were observed in four independent studies, ranging from 44% to 55%. * Watchful waiting for several months may, thus, be a reasonable management option in a particular low-risk group of children with obstructive sleep apnoea. CI - (c) 2026. The Author(s). FAU - Kuhle, Stefan AU - Kuhle S AD - Institute of Clinical Epidemiology, Public Health, Health Economics, Medical Statistics and Informatics, Medical University of Innsbruck, Innsbruck, Austria. FAU - Poets, Christian F AU - Poets CF AD - Department of Neonatology and Division of Paediatric Sleep Medicine, University Children's Hospital, Tubingen, Germany. FAU - Urschitz, Michael S AU - Urschitz MS AD - Division of Paediatric Epidemiology, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre of the Johannes Gutenberg-University, Mainz, Germany. urschitz@uni-mainz.de. LA - eng PT - Journal Article PT - Review DEP - 20260813 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Watchful Waiting MH - *Sleep Apnea, Obstructive/therapy/surgery MH - *Adenoidectomy MH - *Tonsillectomy MH - Child MH - Child, Preschool MH - Polysomnography MH - Randomized Controlled Trials as Topic MH - Severity of Illness Index MH - Treatment Outcome MH - Adolescent PMC - PMC13473323 OTO - NOTNLM OT - Adenotonsillectomy OT - Apnoea OT - Children OT - Polysomnography OT - Sleep OT - Watchful waiting COIS- Declarations. Ethics approval, accordance, consent to participate and consent to publish: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/08/14 05:38 MHDA- 2026/08/14 05:39 PMCR- 2026/08/13 CRDT- 2026/08/13 23:55 PHST- 2026/03/23 00:00 [received] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/03 00:00 [revised] PHST- 2026/08/14 05:39 [medline] PHST- 2026/08/14 05:38 [pubmed] PHST- 2026/08/13 23:55 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - 10.1007/s00431-026-07330-6 [pii] AID - 7330 [pii] AID - 10.1007/s00431-026-07330-6 [doi] PST - epublish SO - Eur J Pediatr. 2026 Aug 13;185(9):663. doi: 10.1007/s00431-026-07330-6. PMID- 42595351 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 1447-0756 (Electronic) IS - 1341-8076 (Print) IS - 1341-8076 (Linking) VI - 52 IP - 8 DP - 2026 Aug TI - Evaluation of Maternal Serum ELABELA Levels in Pregnancies Diagnosed With Abortus Imminens Between 8 and 14 Weeks of Gestation. PG - e70450 LID - 10.1111/jog.70450 [doi] LID - e70450 AB - AIM: Abortus imminens is a common condition in early pregnancy characterized by vaginal bleeding with a closed cervix and viable intrauterine pregnancy. Current biochemical markers have limited accuracy in predicting pregnancy outcomes. ELABELA (also known as Apela or Toddler), a peptide involved in angiogenesis and placental development, may serve as a potential biomarker in early pregnancy complications. This study aimed to evaluate maternal serum ELABELA levels in pregnancies diagnosed with abortus imminens. METHODS: This prospective cross-sectional study included 45 pregnant women diagnosed with abortus imminens between 8 and 14 weeks of gestation and 45 healthy controls. Maternal serum ELABELA levels were measured using enzyme-linked immunosorbent assay (ELISA). All serum samples were analyzed simultaneously in a single analytical batch to minimize interassay variability. Statistical analyses included group comparisons, receiver operating characteristic (ROC) curve analysis, and binary logistic regression. RESULTS: There were no significant differences between groups in terms of age, body mass index (BMI), gestational age at sampling, gravidity, or parity (p > 0.05). ELABELA levels were significantly lower in the abortus imminens group compared with controls (median: 649.82 vs. 859.60 pg/mL; p = 0.021). ROC analysis demonstrated modest discriminative ability (area under the curve [AUC] = 0.641; 95% confidence interval [CI]: 0.520-0.751), with an optimal cut-off value of 712.0 pg/mL (sensitivity 60.0%, specificity 68.9%). Logistic regression analysis showed no independent predictive value for ELABELA. CONCLUSION: Maternal serum ELABELA levels are significantly reduced in pregnancies with abortus imminens, suggesting a potential role in early placental dysfunction. Although ELABELA alone may not be a strong independent predictor, it may serve as a complementary biomarker in the evaluation of abortus imminens. Further large-scale prospective studies are needed to confirm these findings. CI - (c) 2026 Japan Society of Obstetrics and Gynecology. FAU - Ozgedik, Simge AU - Ozgedik S AUID- ORCID: 0009-0002-3241-9984 AD - Department of Obstetrics and Gynecology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Herguner, Metehan AU - Herguner M AUID- ORCID: 0000-0003-3182-6430 AD - Department of Obstetrics and Gynecology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Durace, Alihan AU - Durace A AUID- ORCID: 0009-0007-5848-1467 AD - Department of Obstetrics and Gynecology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Al, Cagdas Necati AU - Al CN AUID- ORCID: 0009-0006-0198-8956 AD - Department of Obstetrics and Gynecology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Yucel, Ecem AU - Yucel E AUID- ORCID: 0000-0002-5941-1926 AD - Department of Obstetrics and Gynecology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Ozgokce, Cagdas AU - Ozgokce C AUID- ORCID: 0000-0003-4960-4625 AD - Department of Obstetrics and Gynecology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Kale, Ibrahim AU - Kale I AUID- ORCID: 0000-0001-7802-7199 AD - Department of Obstetrics and Gynecology, University of Health Sciences, Umraniye Training and Research Hospital, Istanbul, Turkey. LA - eng PT - Journal Article PL - Australia TA - J Obstet Gynaecol Res JT - The journal of obstetrics and gynaecology research JID - 9612761 RN - 0 (Peptide Hormones) RN - 0 (APELA protein, human) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Peptide Hormones/blood MH - Biomarkers/blood MH - Adult MH - Prospective Studies MH - Cross-Sectional Studies MH - *Pregnancy Trimester, First/blood PMC - PMC13472750 OTO - NOTNLM OT - ELABELA OT - abortus imminens OT - biomarker OT - early pregnancy OT - placental dysfunction COIS- The authors have nothing to report. The authors declare no conflicts of interest. EDAT- 2026/08/14 04:30 MHDA- 2026/08/14 04:31 PMCR- 2026/08/13 CRDT- 2026/08/13 20:33 PHST- 2026/07/08 00:00 [revised] PHST- 2026/05/04 00:00 [received] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/14 04:31 [medline] PHST- 2026/08/14 04:30 [pubmed] PHST- 2026/08/13 20:33 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - JOG70450 [pii] AID - 10.1111/jog.70450 [doi] PST - ppublish SO - J Obstet Gynaecol Res. 2026 Aug;52(8):e70450. doi: 10.1111/jog.70450. PMID- 42595669 OWN - NLM STAT- MEDLINE DCOM- 20261001 LR - 20261005 IS - 2529-993X (Electronic) IS - 2529-993X (Linking) VI - 44 IP - 8 DP - 2026 Oct TI - Evaluation of risk factors and development of a predictive clinical score for TB contact tracing in Angola. PG - 503251 LID - S2529-993X(26)00152-8 [pii] LID - 10.1016/j.eimce.2026.503251 [doi] AB - INTRODUCTION: Contact tracing for tuberculosis (TB) is an essential component of public health efforts to detect secondary cases and interrupt transmission chains. This study aimed to assess the risk factors associated with TB diagnosis and to develop a predictive clinical score for TB diagnosis among contacts of people with TB attending the outpatient clinic at Hospital Nossa Senhora da Paz (HNSP) in Cubal, Angola. METHODS: Prospective observational study including TB contacts of all ages. Data were analyzed using descriptive and inferential statistics, including multivariable logistic regression with multiple imputation for missing data. The performance of the proposed clinical score was assessed through ROC analysis, calibration, bootstrap internal validation, and comparison with the WHO symptom-based screening approach. RESULTS: Two-hundred and eighty-five TB contacts were included. Fifty (17.5%) contacts were diagnosed with TB, 40 (80%) of whom were children /=6 points, the score showed a sensitivity of 94% and a specificity of 75%, with an area under the ROC curve of 0.89 (95% CI: 0.85-0.94). CONCLUSIONS: These findings highlight the high burden of TB among close contacts and the challenges in properly assessing them. An easy-to-use clinical score may support frontline health workers in improving TB contact tracing in settings with high burden of disease and limited resources, such as Angola. CI - Copyright (c) 2026 Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Martinez-Camprecios, Joan AU - Martinez-Camprecios J AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Tuberculosis Unit, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola. FAU - Aznar, Maria Luisa AU - Aznar ML AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Tuberculosis Unit, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola; Centro de Investigacion Biomedica en Red de Enfermedades (CIBER), Infecciosas, Instituto de Salud Carlos III, Madrid, Spain; Grupo de Estudio de Micobacterias, Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica (SEIMC), Madrid, Spain. Electronic address: maria.aznar@vhir.org. FAU - Espinosa-Pereiro, Juan AU - Espinosa-Pereiro J AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Grupo de Estudio de Micobacterias, Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica (SEIMC), Madrid, Spain; Damien Foundation, Brussels, Belgium. FAU - Aixut, Sandra AU - Aixut S AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Pediatric Unit, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola. FAU - Nindia, Arlete AU - Nindia A AD - Laboratory Department, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola. FAU - Zakarias, Adriano AU - Zakarias A AD - Tuberculosis Unit, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola. FAU - Gonzalez-Farias, Inigo AU - Gonzalez-Farias I AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Tuberculosis Unit, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola. FAU - Comella, Patricia AU - Comella P AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain. FAU - Sicaleta, Nicolau AU - Sicaleta N AD - Pediatric Unit, Hospital Nossa Senhora da Paz, Cubal, Benguela, Angola. FAU - Sanchez-Montalva, Adrian AU - Sanchez-Montalva A AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades (CIBER), Infecciosas, Instituto de Salud Carlos III, Madrid, Spain; Grupo de Estudio de Micobacterias, Sociedad Espanola de Enfermedades Infecciosas y Microbiologia Clinica (SEIMC), Madrid, Spain. FAU - Molina, Israel AU - Molina I AD - Servei de Malalties Infeccioses, Unitat de Medicina Tropical i Salut Internacional, Vall d'Hebron Institut de Recerca (VHIR), Vall d'Hebron Hospital Universitari, Barcelona, Spain; Centro de Investigacion Biomedica en Red de Enfermedades (CIBER), Infecciosas, Instituto de Salud Carlos III, Madrid, Spain. LA - eng PT - Journal Article PT - Observational Study DEP - 20260813 PL - Spain TA - Enferm Infecc Microbiol Clin (Engl Ed) JT - Enfermedades infecciosas y microbiologia clinica (English ed.) JID - 101777541 SB - IM MH - Humans MH - Angola/epidemiology MH - Risk Factors MH - *Contact Tracing/methods MH - Prospective Studies MH - *Tuberculosis/diagnosis/epidemiology/transmission MH - Female MH - Male MH - Adolescent MH - Child MH - Adult MH - Child, Preschool MH - Young Adult MH - Middle Aged MH - Infant OTO - NOTNLM OT - Contact-tracing OT - Estudio de contactos OT - Factores de riesgo OT - Risk factors OT - Tuberculosis EDAT- 2026/08/13 23:36 MHDA- 2026/10/01 23:30 CRDT- 2026/08/13 21:58 PHST- 2026/01/27 00:00 [received] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/10/01 23:30 [medline] PHST- 2026/08/13 23:36 [pubmed] PHST- 2026/08/13 21:58 [entrez] AID - S2529-993X(26)00152-8 [pii] AID - 10.1016/j.eimce.2026.503251 [doi] PST - ppublish SO - Enferm Infecc Microbiol Clin (Engl Ed). 2026 Oct;44(8):503251. doi: 10.1016/j.eimce.2026.503251. Epub 2026 Aug 13. PMID- 42594584 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260923 IS - 1873-5711 (Electronic) IS - 1050-6411 (Linking) VI - 90 DP - 2026 Oct TI - Nonimpaired literature-derived scaling does not accurately represent the shoulder and elbow strength of children and adults with paraplegia. PG - 103197 LID - S1050-6411(26)00094-5 [pii] LID - 10.1016/j.jelekin.2026.103197 [doi] AB - This study evaluated whether participant characteristics, literature-derived regression equations, and a generic musculoskeletal model developed for nonimpaired populations could accurately predict maximal shoulder and elbow strength in children and adults with paraplegia. Thirty individuals with paraplegia (22 adults, 8 children) completed maximal voluntary isometric contractions (MVICs) in seven upper extremity postures. Predicted MVICs were generated using a scaled OpenSim upper extremity model with three muscle activation inputs (Full, Separated, and EMG-informed). Linear mixed-effects models evaluated relationships between predicted and experimentally measured MVICs across postures. Model performance was assessed using marginal and conditional R(2), root mean square error (RMSE), mean absolute error (MAE), Lin's concordance correlation coefficient (CCC), and repeated-measures Bland-Altman analyses. Agreement between measured and height-predicted upper extremity segment lengths was also evaluated. Joint posture significantly influenced measured MVIC, and significant posture-by-predicted MVIC interactions demonstrated that prediction accuracy was posture dependent (all p < 0.001). The Full activation input explained the greatest proportion of variance in measured MVIC (marginal R(2) = 0.770; conditional R(2) = 0.931), whereas the EMG-informed activation input produced the lowest prediction error (RMSE = 22.38% MVIC; MAE = 17.14% MVIC). However, agreement between predicted and measured MVIC remained modest across all activation inputs (CCC = 0.259-0.312), with systematic bias evident in Bland-Altman analyses. Height-based anthropometric scaling overestimated forearm and humerus lengths by 1.25 and 4.96 cm, respectively, with greater error for the humerus (RMSE = 5.82 cm). Regression-based scaling and generic musculoskeletal models derived from nonimpaired populations provided only modest estimates of maximal upper extremity strength in individuals with paraplegia. Improving strength prediction will require innovative scaling approaches that incorporate participant-specific anthropometry, population-specific muscle properties, and individualized neuromuscular activation while balancing model accuracy with practical clinical feasibility. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Zhao, Hanhsen AU - Zhao H AD - Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA. FAU - Cho, Yeajin AU - Cho Y AD - Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA. FAU - Schnorenberg, Alyssa J AU - Schnorenberg AJ AD - Department of Biomedical Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI, USA; Department of Occupational Science and Technology, College of Health Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA. FAU - Slavens, Brooke A AU - Slavens BA AD - Department of Biomedical Engineering, University of Wisconsin-Milwaukee, Milwaukee, WI, USA; Department of Occupational Science and Technology, College of Health Sciences, University of Wisconsin-Milwaukee, Milwaukee, WI, USA. FAU - Peterson, Carrie L AU - Peterson CL AD - Department of Biomedical Engineering, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: clpeterson@vcu.edu. LA - eng PT - Journal Article DEP - 20260810 PL - England TA - J Electromyogr Kinesiol JT - Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology JID - 9109125 SB - IM MH - Humans MH - *Paraplegia/physiopathology MH - Child MH - Male MH - Female MH - Adult MH - *Muscle Strength/physiology MH - Isometric Contraction/physiology MH - *Muscle, Skeletal/physiopathology MH - *Elbow Joint/physiopathology MH - *Models, Biological MH - *Shoulder Joint/physiopathology MH - Reproducibility of Results MH - Sensitivity and Specificity OTO - NOTNLM OT - Musculoskeletal modeling OT - Peak isometric moment OT - Spinal cord injury OT - Upper extremity COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/13 23:36 MHDA- 2026/09/23 23:55 CRDT- 2026/08/13 18:05 PHST- 2025/06/30 00:00 [received] PHST- 2026/07/30 00:00 [revised] PHST- 2026/08/09 00:00 [accepted] PHST- 2026/09/23 23:55 [medline] PHST- 2026/08/13 23:36 [pubmed] PHST- 2026/08/13 18:05 [entrez] AID - S1050-6411(26)00094-5 [pii] AID - 10.1016/j.jelekin.2026.103197 [doi] PST - ppublish SO - J Electromyogr Kinesiol. 2026 Oct;90:103197. doi: 10.1016/j.jelekin.2026.103197. Epub 2026 Aug 10. PMID- 42594228 OWN - NLM STAT- MEDLINE DCOM- 20260928 LR - 20260928 IS - 1536-3678 (Electronic) IS - 1077-4114 (Linking) VI - 48 IP - 7 DP - 2026 Oct 1 TI - Beyond Tumor Size: Hilar-to-Central Vessel Distance as a Complementary Safety Metric for Laparoscopic Nephrectomy in Wilms Tumor. PG - 323-330 LID - 10.1097/MPH.0000000000003264 [doi] AB - BACKGROUND: Laparoscopic nephrectomy for Wilms tumor remains controversial despite growing evidence supporting its feasibility. This study analyzed surgical and oncological outcomes according to the SIOP criteria and evaluated the hilar-to-central vessel distance as a potential selection parameter. METHODS: Retrospective analysis of 50 children with unilateral Wilms tumor treated between 2014 and 2020. Patients underwent open (ON=38) or laparoscopic (LN=12) nephrectomy following SIOP protocols. Laparoscopic selection required: tumor confined to the kidney, not crossing vertebral border, no venous thrombus, volume 1 year. The definition of advanced BA as BA-CA >1 year is widely adopted in clinical pediatric practice in China. RESULTS: The prevalence of advanced BA was 7.9%, with significantly higher rates in girls (11.9% vs. 3.4% in boys, P<0.001), children aged 9-12 years (19.4%), and those with overweight (17.1%) or obesity (16.9%) compared to normal weight children (5.8%, P<0.001). Body mass index (BMI) was positively correlated with advanced BA (Spearman rho=0.361, P<0.001) and exhibited moderate predictive value for advanced BA [area under the curve (AUC) =0.735; 95% confidence interval (CI): 0.684-0.786]. Overweight and obesity were associated with increased odds of advanced BA after adjustment for age and sex [overweight: odds ratio (OR) =2.49, 95% CI: 1.435-4.314, P<0.05; obesity: OR =2.33, 95% CI: 1.463-3.71, P<0.001], whereas serum 25(OH)D levels showed no significant association. CONCLUSIONS: Overweight and obesity were significantly associated with advanced BA in this cross-sectional cohort of children from northwest China, whereas no significant association was detected between serum 25(OH)D and advanced BA. These findings highlight the importance of nutritional monitoring for healthy skeletal development in economically transitioning regions. CI - (c) AME Publishing Company. FAU - Li, Tingting AU - Li T AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Nan, Nan AU - Nan N AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Wei, Wenjie AU - Wei W AD - Academy of Fine Art & Design, Northwest Normal University, Lanzhou, China. FAU - Zhu, Yin AU - Zhu Y AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Huang, Lei AU - Huang L AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Ma, Xuerong AU - Ma X AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Du, Yongxia AU - Du Y AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Zhang, Naqi AU - Zhang N AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - An, Dandan AU - An D AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Bai, Wenjie AU - Bai W AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Fan, Hongyan AU - Fan H AD - Department of Child Health Care, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Wang, Chen AU - Wang C AD - Department of Scientific and Technological Development, Gansu Provincial Maternity and Child-Care Hospital, Lanzhou, China. FAU - Da, Zhenqiang AU - Da Z AD - Department of Medical Administration, Gansu Provincial Cancer Hospital, Lanzhou, China. FAU - Xie, Xingwen AU - Xie X AUID- ORCID: 0009-0006-2454-635X AD - Department of Orthopedics, Affiliated Hospital of Gansu University of Chinese Medicine, Lanzhou, China. LA - eng PT - Journal Article DEP - 20260629 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13462753 OTO - NOTNLM OT - Body mass index (BMI) OT - bone age (BA) OT - children OT - northwest China OT - serum 25-hydroxyvitamin D [serum 25(OH)D] COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0378/coif). The authors have no conflicts of interest to declare. EDAT- 2026/08/13 12:42 MHDA- 2026/08/13 12:43 PMCR- 2026/07/31 CRDT- 2026/08/13 06:56 PHST- 2026/04/16 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/08/13 12:43 [medline] PHST- 2026/08/13 12:42 [pubmed] PHST- 2026/08/13 06:56 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - tp-15-07-266 [pii] AID - 10.21037/tp-2026-0378 [doi] PST - ppublish SO - Transl Pediatr. 2026 Jul 31;15(7):266. doi: 10.21037/tp-2026-0378. Epub 2026 Jun 29. PMID- 42592010 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260814 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 7 DP - 2026 Jul 31 TI - Development of a parsimonious predictive model for height gain outcome in children with central precocious puberty following gonadotropin-releasing hormone agonist therapy. PG - 284 LID - 10.21037/tp-2026-0254 [doi] LID - 284 AB - BACKGROUND: Central precocious puberty (CPP) is associated with compromised adult height if untreated, and gonadotropin-releasing hormone agonist (GnRHa) therapy remains the standard treatment. However, height gain during treatment varies considerably among patients, and clinically practical tools for early identification of children at risk for suboptimal growth response are lacking. This study aimed to identify prognostic determinants of suboptimal height gain during GnRHa therapy and to develop a parsimonious predictive model to facilitate evidence-based clinical decision-making and optimal intervention timing. METHODS: A retrospective cohort study was conducted enrolling children with CPP treated with triptorelin. Baseline clinical and biochemical parameters were collected, including chronological age, height standard deviation score (SDS), body mass index (BMI) SDS, insulin-like growth factor-1 (IGF-1) SDS, bone age advancement [bone age minus chronological age (BA-CA)], Tanner stage, GnRH-stimulated luteinizing hormone (LH) peak, and serum estradiol concentrations. Patients were stratified into favorable and unfavorable outcome cohorts based on height gain during treatment. Univariate and multivariable logistic regression analyses were performed to identify independent predictors. Three predictive models were constructed: M0 (comprehensive model with five predictors: IGF-1 SDS, BMI SDS, BA-CA, Tanner stage, and age), M1 (univariate model with IGF-1 SDS), and M2 (parsimonious model with IGF-1 SDS and BA-CA). Model performance was assessed using receiver operating characteristic (ROC) curves, calibration plots, decision curve analysis (DCA; 1-50% risk thresholds), and bootstrap internal validation. RESULTS: A total of 163 children with CPP were enrolled (favorable outcome: n=113; unfavorable outcome: n=50). Multivariable logistic regression identified BMI SDS [odds ratio (OR) =2.33, 95% confidence interval (CI): 1.14-4.76, P=0.02], IGF-1 SDS (OR =1.94, 95% CI: 1.24-3.02, P=0.004), and bone age advancement (OR =21.49, 95% CI: 5.41-85.30, P<0.001) as independent predictors for unfavorable outcome. The area under the curve (AUC) was 0.838 (95% CI: 0.774-0.903) for M0, 0.664 (95% CI: 0.573-0.754) for M1, and 0.815 (95% CI: 0.748-0.883) for M2. DeLong test revealed no significant difference between M2 and M0 (DeltaAUC =-0.023, P=0.24). Bootstrap internal validation (1,000 iterations) demonstrated optimism-corrected AUC values of 0.810, 0.661, and 0.807 for M0, M1, and M2, respectively. M2 exhibited optimal calibration slope (0.957, 95% CI: 0.642-1.389) closest to unity. Brier scores were 0.160 for M0 and 0.167 for M2. DCA demonstrated comparable clinical net benefit for M0 and M2 across 1-50% risk thresholds. CONCLUSIONS: The parsimonious model (M2) incorporating IGF-1 SDS and bone age advancement demonstrates robust predictive capability for height gain outcome in children with CPP receiving GnRHa therapy, comparable to the comprehensive model. This model may support early risk stratification and closer growth monitoring in selected patients; however, external validation and confirmation against final adult height outcomes are required before it can inform decisions about adjunctive interventions. CI - (c) AME Publishing Company. FAU - Lin, Xiaohong AU - Lin X AD - Department of Pediatrics, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Lin, Kai AU - Lin K AD - Department of Radiology, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Ye, Pengcheng AU - Ye P AD - Department of Pediatrics, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Wang, Ben AU - Wang B AD - Department of Laboratory, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Huang, Chongbin AU - Huang C AD - Department of Pediatrics, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Hong, Jianyu AU - Hong J AD - Department of Pediatrics, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Xue, Yunyun AU - Xue Y AD - Department of Medical Affairs, Yueqing Maternal and Child Health Hospital, Yueqing, China. FAU - Qian, Xiaoquan AU - Qian X AUID- ORCID: 0009-0002-9549-5677 AD - Department of Pathology, Yueqing Maternal and Child Health Hospital, Yueqing, China. LA - eng PT - Journal Article DEP - 20260727 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13462843 OTO - NOTNLM OT - Central precocious puberty (CPP) OT - bone age OT - gonadotropin-releasing hormone agonist (GnRHa) OT - height outcome OT - insulin-like growth factor-1 (IGF-1) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0254/coif). The authors have no conflicts of interest to declare. EDAT- 2026/08/13 12:42 MHDA- 2026/08/13 12:43 PMCR- 2026/07/31 CRDT- 2026/08/13 06:52 PHST- 2026/03/12 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/08/13 12:43 [medline] PHST- 2026/08/13 12:42 [pubmed] PHST- 2026/08/13 06:52 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - tp-15-07-284 [pii] AID - 10.21037/tp-2026-0254 [doi] PST - ppublish SO - Transl Pediatr. 2026 Jul 31;15(7):284. doi: 10.21037/tp-2026-0254. Epub 2026 Jul 27. PMID- 42591968 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260814 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 7 DP - 2026 Jul 31 TI - An interpretable machine learning model based on routine clinical indicators for early identification of obesity-related non-alcoholic fatty liver disease in children: a single-center retrospective study. PG - 275 LID - 10.21037/tp-2026-0371 [doi] LID - 275 AB - BACKGROUND: There is still a lack of a noninvasive, individualized tool to pre-screen children with obesity for the risk of non-alcoholic fatty liver disease (NAFLD) and to prioritize referral for confirmatory abdominal ultrasonography. In this study, we aimed to develop and interpret a machine learning (ML)-based model for predicting ultrasound-defined NAFLD risk among children with obesity using routine clinical and biochemical indicators. METHODS: This single-center retrospective study included 439 obese children treated at Siyang Hospital between February 2021 and December 2025. Demographic, anthropometric, and routine laboratory indicators were collected, and ultrasound-defined NAFLD was used as the study outcome. Least absolute shrinkage and selection operator (LASSO) regression and the Boruta algorithm were applied to identify robust predictive features, and six ML models-logistic regression, decision tree, random forest, extreme gradient boosting (XGBoost), light gradient boosting machine (LightGBM), and support vector machine (SVM)-were developed and compared to determine the optimal model. Model performance was evaluated in the test set, and Shapley Additive exPlanations (SHAP) was used to interpret the final model. RESULTS: A total of 439 obese children were included in the analysis, of whom 206 (46.9%) had ultrasound-defined NAFLD. Seven variables were selected to develop six ML models. Among these, the LightGBM model showed the best overall performance across multiple metrics, with comparable discrimination among the top models in the test set, with an area under the curve (AUC) of 0.870, accuracy of 0.823, precision of 0.828, sensitivity of 0.787, specificity of 0.855, and F1 score of 0.807. SHAP analysis further demonstrated that waist-to-height ratio contributed most to the model output, followed by body mass index (BMI), triglyceride-glucose index x waist circumference (TyG-WC), serum uric acid, and triglyceride-glucose index x body mass index (TyG-BMI). CONCLUSIONS: This study developed an interpretable ML-based model for predicting ultrasound-defined NAFLD risk in obese children using routine clinical and biochemical indicators. LightGBM showed the best overall predictive performance, with good calibration and potential clinical utility. It may serve as a noninvasive auxiliary tool to pre-screen children with obesity and prioritize referral for confirmatory abdominal ultrasonography, supporting early identification and risk assessment of ultrasound-defined NAFLD, although further multicenter prospective studies and external validation are still needed before broader clinical application. CI - (c) AME Publishing Company. FAU - Zhuang, Lili AU - Zhuang L AD - Department of Pediatrics, Siyang Hospital, Suqian, China. FAU - Dai, Jinxing AU - Dai J AD - Department of Pediatrics, Siyang Hospital, Suqian, China. FAU - Wang, Jiajia AU - Wang J AD - Cancer Center, Siyang Hospital, Suqian, China. FAU - Shi, Qianjin AU - Shi Q AD - Cancer Center, Siyang Hospital, Suqian, China. FAU - Shen, Kang AU - Shen K AD - Cancer Center, Siyang Hospital, Suqian, China. FAU - Qiu, Hao AU - Qiu H AD - Cancer Center, Siyang Hospital, Suqian, China. FAU - Qiu, Weibing AU - Qiu W AD - Department of Pediatrics, Siyang Hospital, Suqian, China. LA - eng PT - Journal Article DEP - 20260627 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13462896 OTO - NOTNLM OT - Childhood obesity OT - Shapley Additive exPlanations (SHAP) OT - light gradient boosting machine (LightGBM) OT - machine learning (ML) OT - non-alcoholic fatty liver disease (NAFLD) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0371/coif). The authors have no conflicts of interest to declare. EDAT- 2026/08/13 12:43 MHDA- 2026/08/13 12:44 PMCR- 2026/07/31 CRDT- 2026/08/13 06:48 PHST- 2026/04/17 00:00 [received] PHST- 2026/06/05 00:00 [accepted] PHST- 2026/08/13 12:44 [medline] PHST- 2026/08/13 12:43 [pubmed] PHST- 2026/08/13 06:48 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - tp-15-07-275 [pii] AID - 10.21037/tp-2026-0371 [doi] PST - ppublish SO - Transl Pediatr. 2026 Jul 31;15(7):275. doi: 10.21037/tp-2026-0371. Epub 2026 Jun 27. PMID- 42591473 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260814 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Diagnosis and treatment of vitamin B12 deficiency in children. PG - 1883501 LID - 10.3389/fnut.2026.1883501 [doi] LID - 1883501 AB - Vitamin B12 deficiency is a common yet frequently underrecognized nutritional disorder with important public health implications, particularly in low- and middle-income countries where maternal deficiency, vegetarian dietary practices, and food insecurity are prevalent. In children, deficiency may lead to irreversible neurodevelopmental impairment, growth failure, and hematological abnormalities, making early recognition essential. The clinical spectrum ranges from asymptomatic biochemical deficiency and isolated macrocytic anemia to developmental regression, seizures, movement disorders, peripheral neuropathy, and pancytopenia, with neurological manifestations often preceding hematological changes. Diagnosis requires integration of clinical features with laboratory evaluation, including complete blood count, peripheral smear, serum vitamin B12 estimation, and functional biomarkers such as methylmalonic acid and homocysteine, which improve diagnostic accuracy in borderline or atypical cases. Molecular testing has expanded the identification of inherited disorders affecting vitamin B12 absorption and metabolism, enabling timely lifelong management. Prompt replacement therapy is the cornerstone of treatment and should not be delayed when clinical suspicion is high. Oral supplementation is effective for most dietary deficiencies, whereas parenteral therapy is indicated for severe anemia, neurological involvement, malabsorption, or inherited cobalamin disorders. Early treatment results in rapid hematological recovery, but delayed intervention may leave permanent neurological sequelae despite biochemical correction. Beyond individual patient care, strengthening maternal nutrition, targeted screening of high-risk populations, food fortification, and public awareness are critical strategies to reduce the burden of vitamin B12 deficiency and prevent avoidable disability. This review summarizes current evidence on the diagnosis and treatment of pediatric vitamin B12 deficiency and highlights practical approaches for improving clinical outcomes. CI - Copyright (c) 2026 Kanvinde, Khurana and Mudaliar. FAU - Kanvinde, Purva AU - Kanvinde P AD - Department of Paediatric Hematology-Oncology, Bai Jerbai Wadia Hospital for Children, Mumbai, India. FAU - Khurana, Ritika AU - Khurana R AD - Department of Paediatric Hematology-Oncology, Bai Jerbai Wadia Hospital for Children, Mumbai, India. FAU - Mudaliar, Sangeeta AU - Mudaliar S AD - Department of Paediatric Hematology-Oncology, Bai Jerbai Wadia Hospital for Children, Mumbai, India. LA - eng PT - Journal Article PT - Review DEP - 20260729 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13462225 OTO - NOTNLM OT - holotranscobalamin OT - inherited vitamin B12 disorders OT - methylmalonic acid levels OT - treatment of vitamin B12 deficiency OT - vitamin B12 deficiency COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/13 12:42 MHDA- 2026/08/13 12:43 PMCR- 2026/07/29 CRDT- 2026/08/13 05:52 PHST- 2026/05/17 00:00 [received] PHST- 2026/06/23 00:00 [revised] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/08/13 12:43 [medline] PHST- 2026/08/13 12:42 [pubmed] PHST- 2026/08/13 05:52 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.3389/fnut.2026.1883501 [doi] PST - epublish SO - Front Nutr. 2026 Jul 29;13:1883501. doi: 10.3389/fnut.2026.1883501. eCollection 2026. PMID- 42591247 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260814 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - The impact of physical activity on executive function in college students: the chain mediating role of anxiety and sleep quality. PG - 1853278 LID - 10.3389/fpsyg.2026.1853278 [doi] LID - 1853278 AB - BACKGROUND AND OBJECTIVES: Executive function (EF) serves as a critical regulatory hub for goal-directed behavior, yet its operational integrity is increasingly threatened by the sedentary lifestyles and psychological stressors prevalent in higher education. While the cognitive benefits of exercise are documented, the specific pathways through which it navigates psychological and physiological barriers remain underexplored. This study constructs a chain mediation model to elucidate how physical activity (PA) optimizes EF by sequentially modulating anxiety and sleep quality (SQ) among university students. METHODS: Data collection was conducted in December 2025, involving a multi-stage cluster convenience sample of 2,033 students across six Chinese provinces. Participants (mean age 19.0 +/- 1.1) completed a battery of validated instruments, including the Single-Item Measure for PA, the GAD-2 for anxiety, the Single-Item Sleep Quality Scale, and the Adolescent Executive Function Scale. Structural relationships were analyzed using the SPSS PROCESS macro (Model 6) while controlling for demographic covariates such as gender, age, and socioeconomic background. RESULTS: Path analysis confirmed that PA positively predicts EF proficiency, with the direct effect accounting for 49.53% of the total variance. Beyond this direct link, the relationship is substantiated by three distinct mediating trajectories: (1) a psychological pathway via anxiety reduction (31.78%), (2) a physiological pathway via enhanced sleep quality (14.02%), (3) a sequential chain pathway wherein PA alleviates anxiety, which subsequently optimizes sleep, leading to superior executive performance (4.67%). All mediating effects reached statistical significance as evidenced by bootstrap confidence intervals. CONCLUSION: These findings transition the understanding of physical intervention from a unilinear correlation to a multi-systemic synergistic response. Exercise functions not only as a cognitive catalyst but also as a vital buffer that prevents the maladaptive depletion of neural resources by stabilizing emotional oscillations and facilitating physiological restoration. The results underscore the necessity for higher education institutions to integrate physical activity, psychological counseling, and sleep hygiene management into a cohesive framework for cognitive health. CI - Copyright (c) 2026 Li, Wan, Ru, Wang, Wang, Liu, Liang, Zhang and Bao. FAU - Li, Yuhao AU - Li Y AD - Beijing Sport University, Beijing, China. FAU - Wan, Xiaotong AU - Wan X AD - School of Nursing, Anhui Medical University, Hefei, China. FAU - Ru, Aojie AU - Ru A AD - School of Nursing, Anhui Medical University, Hefei, China. FAU - Wang, Yanfei AU - Wang Y AD - Department of Science and Education, Xilingol League Central Hospital, Xilinhot, China. FAU - Wang, Jing AU - Wang J AD - Department of Anesthesiology for Surgery, Xilingol League Central Hospital, Xilinhot, China. FAU - Liu, Yang AU - Liu Y AD - Jishou University, Jishou, China. FAU - Liang, Zhiru AU - Liang Z AD - Department of Hepatobiliary Surgery, Xilingol League Central Hospital, Xilinhot, China. FAU - Zhang, Hui AU - Zhang H AD - School of Nursing, Anhui Medical University, Hefei, China. AD - Department of Nursing, The First Affiliated Hospital of Anhui Medical University (Anhui Public Health Clinical Center), Hefei, China. FAU - Bao, Yin AU - Bao Y AD - Department of Hepatobiliary Surgery, Xilingol League Central Hospital, Xilinhot, China. LA - eng PT - Journal Article DEP - 20260729 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13461551 OTO - NOTNLM OT - anxiety OT - chain mediation OT - college students OT - executive function OT - physical activity OT - sleep quality COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/13 12:42 MHDA- 2026/08/13 12:43 PMCR- 2026/07/29 CRDT- 2026/08/13 05:22 PHST- 2026/04/11 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/08/13 12:43 [medline] PHST- 2026/08/13 12:42 [pubmed] PHST- 2026/08/13 05:22 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1853278 [doi] PST - epublish SO - Front Psychol. 2026 Jul 29;17:1853278. doi: 10.3389/fpsyg.2026.1853278. eCollection 2026. PMID- 42591177 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260814 IS - 2234-943X (Print) IS - 2234-943X (Electronic) IS - 2234-943X (Linking) VI - 16 DP - 2026 TI - Early clinical determinants of adverse outcomes in paediatric febrile neutropenia: a prospective cohort study. PG - 1876009 LID - 10.3389/fonc.2026.1876009 [doi] LID - 1876009 AB - BACKGROUND: Febrile neutropenia (FN) remains a major cause of morbidity and mortality in paediatric haemato-oncology, but routinely available determinants of adverse in-hospital outcome remain incompletely characterised. We aimed to identify baseline clinical, haematological, biochemical, and microbiological factors associated with in-hospital mortality and prolonged fever. METHODS: We conducted a prospective single-centre cohort study of 90 consecutive FN admissions in paediatric haemato-oncology patients. Thirty-nine prespecified baseline predictors were evaluated using Firth penalised-likelihood logistic regression. Multivariable models were prespecified on clinical grounds, and discrimination was internally validated using 500 bootstrap replicates with optimism correction. Prolonged fever was defined as time to defervescence >5 days, with death before defervescence counted as an event. RESULTS: Of 86 mortality-evaluable episodes, 16 children died in hospital (18.6%). In the multivariable mortality model, any respiratory support (adjusted odds ratio [aOR], 11.9; 95% CI, 2.5-56.9) and lower admission albumin (aOR, 0.29 per 1 g/dL increase; 95% CI, 0.11-0.77) showed the strongest associations with death. Active disease (aOR 3.5, 95% CI 0.87-14.2) and gram-negative bacteraemia (aOR 4.2, 95% CI 0.93-18.9) showed directionally adverse but imprecise associations. The bootstrap-corrected AUC was 0.88. Of 60 classifiable episodes for the secondary outcome, 31 (51.7%) had prolonged fever. Prolonged fever was associated with older age (aOR 1.24 per year, 95% CI 1.05-1.48), lower albumin (aOR 0.31 per 1 g/dL increase, 95% CI 0.12-0.82), any respiratory support (aOR 10.0, 95% CI 0.98-102.0), and gram-negative bacteraemia (aOR 5.5, 95% CI 1.01-30.3). The bootstrap-corrected AUC was 0.85. Neutropenia depth and platelet count were not independently associated with either outcome. CONCLUSION: In paediatric haemato-oncology patients with FN, adverse in-hospital outcomes were associated mainly with early or evolving respiratory compromise, lower admission albumin, active disease, and gram-negative bacteraemia. Three of these factors, together with age, were associated with prolonged fever or death before defervescence among classifiable episodes. Albumin should be interpreted as a dynamic marker of acute inflammatory burden, capillary leak, and host reserve rather than as a standalone nutritional measure. These routinely available variables may support exploratory bedside risk appraisal, but external validation is required before clinical implementation. CI - Copyright (c) 2026 Maji, Radhakrishnan, Verma, Diptivilasa and Mandal. FAU - Maji, Manideepa AU - Maji M AD - Postgraduate Institute of Child Health, Noida, India. AD - Hull York Medical School, University of Hull, Hull, United Kingdom. AD - Department of Haematology, Hull University Teaching Hospitals NHS Trust, Hull, United Kingdom. FAU - Radhakrishnan, Nita AU - Radhakrishnan N AD - Postgraduate Institute of Child Health, Noida, India. FAU - Verma, Shruti AU - Verma S AD - Postgraduate Institute of Child Health, Noida, India. FAU - Diptivilasa, Aishvarya AU - Diptivilasa A AD - Postgraduate Institute of Child Health, Noida, India. FAU - Mandal, Saikat AU - Mandal S AD - Translational Medical Sciences, School of Medicine, University of Nottingham, Nottingham, United Kingdom. AD - NIHR Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust, Nottingham, United Kingdom. LA - eng PT - Journal Article DEP - 20260729 PL - Switzerland TA - Front Oncol JT - Frontiers in oncology JID - 101568867 PMC - PMC13461490 OTO - NOTNLM OT - blood cancer OT - childhood cancer OT - febrile neutropenia (FN) OT - neutropenic fever OT - paediatric cancer OT - paediatric cancer care COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/13 12:43 MHDA- 2026/08/13 12:44 PMCR- 2026/07/29 CRDT- 2026/08/13 05:12 PHST- 2026/05/08 00:00 [received] PHST- 2026/06/23 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/08/13 12:44 [medline] PHST- 2026/08/13 12:43 [pubmed] PHST- 2026/08/13 05:12 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.3389/fonc.2026.1876009 [doi] PST - epublish SO - Front Oncol. 2026 Jul 29;16:1876009. doi: 10.3389/fonc.2026.1876009. eCollection 2026. PMID- 42591094 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260814 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Nutrition knowledge among adolescents who participate in sports: a cross-sectional study from Vancouver, Canada. PG - 1898385 LID - 10.3389/fnut.2026.1898385 [doi] LID - 1898385 AB - BACKGROUND: Adequate nutrition, defined as meeting energy and nutrient requirements to support sport-related needs, metabolic function, and growth, is critical for adolescent (14-18 years) athletic performance and health. Many adolescents do not meet current nutrition recommendations and report poor awareness of their nutrient needs (i.e., nutrition knowledge), though trends may differ between male and female adolescents. Most evidence is derived from the United States, with limited data from Canadian populations. The aim of this study was to assess sport nutrition knowledge among male and female adolescents participating in organized sport in the Greater Vancouver area (Canada). METHODS: Adolescents participating in organized sport completed an online questionnaire that collected information on their sport participation, nutrition support and nutrition knowledge using the validated Abridged Nutrition for Sport Knowledge Questionnaire (A-NSKQ; 35 items). Descriptive statistics were generated, and independent samples t-tests assessed sex differences. Multivariable linear regression models were used to compare nutrition knowledge scores between sexes while adjusting for age and sports participation characteristics. RESULTS: Fifty-one adolescents participated (n = 31 females). Few adolescents reported access to a team dietitian (6.1%) or structured nutrition education (26.5%). The mean total A-NSKQ score was 16.49 +/- 4.38 (47.1% correct), indicating poor nutrition knowledge. Mean general and sport nutrition scores were 6.14 +/- 1.92 (of 11) and 10.35 +/- 3.08 (of 24), respectively. No significant sex differences were observed in total, general, or sport nutrition knowledge (all p > 0.05). CONCLUSION: Adolescent athletes in this Greater Vancouver sample demonstrated poor nutrition knowledge, with no differences between sexes. Limited access to dietitians and structured education suggests a need for improved sport nutrition education to support health and athletic development. CI - Copyright (c) 2026 Zhang, Deslippe, McKendry and Cohen. FAU - Zhang, Enhui Evelyn AU - Zhang EE AD - Food, Nutrition and Health, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada. FAU - Deslippe, Alysha L AU - Deslippe AL AD - Department of Health, Kinesiology and Applied Physiology, Concordia University, Montreal, QC, Canada. FAU - McKendry, James AU - McKendry J AD - Food, Nutrition and Health, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada. FAU - Cohen, Tamara R AU - Cohen TR AD - Food, Nutrition and Health, Faculty of Land and Food Systems, University of British Columbia, Vancouver, BC, Canada. AD - BC Children's Hospital Research Institute, Healthy Starts, BC Children's Hospital, Vancouver, BC, Canada. LA - eng PT - Journal Article DEP - 20260729 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13461317 OTO - NOTNLM OT - Canada OT - adolescent athletes OT - dietary behaviour OT - nutrition education OT - sports nutrition knowledge COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/13 12:43 MHDA- 2026/08/13 12:44 PMCR- 2026/07/29 CRDT- 2026/08/13 05:01 PHST- 2026/06/02 00:00 [received] PHST- 2026/07/02 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/13 12:44 [medline] PHST- 2026/08/13 12:43 [pubmed] PHST- 2026/08/13 05:01 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.3389/fnut.2026.1898385 [doi] PST - epublish SO - Front Nutr. 2026 Jul 29;13:1898385. doi: 10.3389/fnut.2026.1898385. eCollection 2026. PMID- 42590622 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 15 DP - 2026 Aug 1 TI - Assessing Sprint Mechanical Outputs Derived from LPS, Radar and Laser Technologies in Basketball. LID - 10.3390/s26154845 [doi] LID - 4845 AB - Sprint mechanical profiling is widely used in team sports, yet the agreement between field-based measurement systems in indoor environments remains unclear. This study compared sprint mechanical outputs derived from a Kinexon local positioning system (LPS), radar, and laser during maximal indoor basketball sprints and examined their inter-system agreement and inter-trial reliability. Twenty-two elite youth basketball players performed maximal 28 m linear sprints recorded simultaneously using the three technologies. Sprint kinematics were modeled using a mono-exponential approach applied to the native signals provided by each system to derive theoretical maximal velocity (S(0)), theoretical maximal acceleration (A(0)), and acceleration time constant (Tau). Inter-system agreement was assessed using mean bias and 95% limits of agreement, while inter-trial reliability was evaluated using coefficients of variation (CV), change in the mean, and standard error of measurement. Radar and laser showed close agreement for S(0) (bias = -0.07 +/- 0.17 m.s(-1); relative error = 0.89%), whereas LPS systematically overestimated S(0), with relative systematic errors of 5.26-6.49%. Acceleration-related parameters exhibited larger inter-system discrepancies, with relative errors up to 3.92% for A(0) and 10.55% for Tau. Inter-trial reliability was high across all systems (CV < 1.5% for S(0) and 3.7-4.7% for A(0) and Tau). These findings indicate that sprint mechanical outputs should not be used interchangeably across technologies, particularly for acceleration-related variables, although all systems remain suitable for within-system longitudinal monitoring in applied basketball settings. FAU - Irid, Yannis AU - Irid Y AUID- ORCID: 0009-0006-9648-4127 AD - IRMES-UMR 7329, Institut de Recherche Medicale et d'Epidemiologie du Sport, Universite de Paris Cite, 75012 Paris, France. AD - Institut National du Sport, de l'Expertise et de la Performance (INSEP), 75012 Paris, France. AD - Federation Francaise de Basketball (FFBB), 75013 Paris, France. FAU - Fenaux, Eric AU - Fenaux E AD - Ef-E-Sciences, Independent Scientific Consultancy, 75009 Paris, France. FAU - Legoupil, Romeo AU - Legoupil R AUID- ORCID: 0009-0001-7362-5402 AD - IRMES-UMR 7329, Institut de Recherche Medicale et d'Epidemiologie du Sport, Universite de Paris Cite, 75012 Paris, France. FAU - Tachdjian, Mathis AU - Tachdjian M AD - Institut National du Sport, de l'Expertise et de la Performance (INSEP), 75012 Paris, France. FAU - Leduc, Cedric AU - Leduc C AUID- ORCID: 0000-0002-8054-546X AD - IRMES-UMR 7329, Institut de Recherche Medicale et d'Epidemiologie du Sport, Universite de Paris Cite, 75012 Paris, France. AD - Center for Human Performance, Carnegie School of Sport, Leeds Beckett University, Leeds LS1 3HE, UK. AD - Federation Francaise de Tennis (FFT), 75016 Paris, France. FAU - Toussaint, Jean-Francois AU - Toussaint JF AD - IRMES-UMR 7329, Institut de Recherche Medicale et d'Epidemiologie du Sport, Universite de Paris Cite, 75012 Paris, France. AD - Institut National du Sport, de l'Expertise et de la Performance (INSEP), 75012 Paris, France. AD - Centre d'Investigation en Medecine du Sport, Assistance Publique-Hopitaux de Paris, Hotel-Dieu, 75004 Paris, France. FAU - Sedeaud, Adrien AU - Sedeaud A AUID- ORCID: 0000-0002-8492-3579 AD - IRMES-UMR 7329, Institut de Recherche Medicale et d'Epidemiologie du Sport, Universite de Paris Cite, 75012 Paris, France. AD - Institut National du Sport, de l'Expertise et de la Performance (INSEP), 75012 Paris, France. LA - eng PT - Journal Article DEP - 20260801 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Basketball/physiology MH - *Lasers MH - *Radar MH - Biomechanical Phenomena MH - Acceleration MH - *Running/physiology MH - Reproducibility of Results PMC - PMC13468825 OTO - NOTNLM OT - acceleration mechanics OT - athlete monitoring OT - indoor tracking OT - sprint profiling OT - team sports COIS- The authors declare no conflicts of interest. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/01 CRDT- 2026/08/13 01:08 PHST- 2026/04/17 00:00 [received] PHST- 2026/06/02 00:00 [revised] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:08 [entrez] PHST- 2026/08/01 00:00 [pmc-release] AID - s26154845 [pii] AID - sensors-26-04845 [pii] AID - 10.3390/s26154845 [doi] PST - epublish SO - Sensors (Basel). 2026 Aug 1;26(15):4845. doi: 10.3390/s26154845. PMID- 42590224 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260815 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 15 DP - 2026 Aug 6 TI - Early Childhood Caries and Immunonutritional Status in Preschool Children: A Retrospective Comparative Study of the HALP Score and Hematological Biomarkers. LID - 10.3390/jcm15156122 [doi] LID - 6122 AB - Background: Early childhood caries (ECC) is a common chronic disease in children and has been associated with systemic inflammatory and nutritional alterations. The hemoglobin, albumin, lymphocyte, and platelet (HALP) score reflects immunonutritional status. This study investigated the associations of the HALP score and hematological parameters with ECC, caries burden, and periapical disease severity. Methods: This retrospective comparative study included 126 preschool children: 97 with ECC and 29 caries-free controls. Participants were further classified into low (Periapical Index (PAI) 1-3) and high (PAI 4-5) periapical disease severity groups according to the highest Periapical Index score. The HALP score was calculated using the standard formula. Statistical significance was set at p < 0.05. Results: No statistically significant association was detected between the HALP score and ECC, dmft, or periapical disease severity (p > 0.05). Albumin levels were higher in the ECC group than in controls (p < 0.001). Neither the HALP score nor its individual hematological components were associated with caries burden in negative binomial regression analyses (p > 0.05). Greater caries burden was independently associated with severe periapical disease (Odds Ratio (OR) = 1.19, 95% Confidence Interval (CI): 1.09-1.30, p < 0.001), whereas hemoglobin was not (p = 0.052). Conclusions: No statistically significant association was detected between the HALP score and ECC status, caries burden, or periapical disease severity. Although albumin levels differed between children with ECC and caries-free controls, neither the HALP score nor its individual hematological components were independently associated with caries burden. Larger prospective multicenter studies are needed to validate these findings. FAU - Celikel, Peris AU - Celikel P AD - Department of Pediatric Dentistry, Faculty of Dentistry, Ataturk University, Erzurum 25040, Turkey. FAU - Yaptirmis, Yesim AU - Yaptirmis Y AD - Department of Pediatric Dentistry, Faculty of Dentistry, Ataturk University, Erzurum 25040, Turkey. FAU - Bilici, Elif AU - Bilici E AD - Department of Periodontology, Faculty of Dentistry, Ataturk University, Erzurum 25040, Turkey. FAU - Ugurlu, Hacer Umay AU - Ugurlu HU AUID- ORCID: 0009-0009-7588-0851 AD - Department of Periodontology, Faculty of Dentistry, Ataturk University, Erzurum 25040, Turkey. FAU - Ceylan, Erol Emir AU - Ceylan EE AUID- ORCID: 0000-0001-7927-3455 AD - Department of Periodontology, Faculty of Dentistry, Ataturk University, Erzurum 25040, Turkey. FAU - Cetinkaya, Fuat AU - Cetinkaya F AD - Department of Periodontology, Faculty of Dentistry, Ataturk University, Erzurum 25040, Turkey. FAU - Sengul, Fatih AU - Sengul F AD - Department of Pediatric Dentistry, Faculty of Dentistry, Ataturk University, Erzurum 25040, Turkey. LA - eng PT - Journal Article DEP - 20260806 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13467548 OTO - NOTNLM OT - albumins OT - biomarkers OT - child OT - dental caries OT - hemoglobin OT - pediatric dentistry COIS- The authors declare no competing interests. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/06 CRDT- 2026/08/13 01:06 PHST- 2026/07/12 00:00 [received] PHST- 2026/07/24 00:00 [revised] PHST- 2026/08/06 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:06 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - jcm15156122 [pii] AID - jcm-15-06122 [pii] AID - 10.3390/jcm15156122 [doi] PST - epublish SO - J Clin Med. 2026 Aug 6;15(15):6122. doi: 10.3390/jcm15156122. PMID- 42589895 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260815 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 15 DP - 2026 Jul 24 TI - Strong Family-Level Clustering of Adolescent Weight Status Despite Limited Associations with Individual Parental Anthropometric and Metabolic Characteristics. LID - 10.3390/jcm15155790 [doi] LID - 5790 AB - Objectives: Familial aggregation of obesity has been consistently reported; however, previous studies have predominantly relied on body mass index (BMI)-based associations and have dedicated insufficient time to examining the contribution of measurable parental biological traits to family-level clustering. We investigated associations between parental anthropometric and metabolic characteristics and adolescent weight status in families in which at least one parent had obesity, while exploring family-level clustering patterns. Methods: This cross-sectional family-based study included 34 families comprising 110 individuals (65 parents and 45 adolescents) consecutively recruited from primary care registries. Participants underwent anthropometric and biochemical evaluation, including indices of central body fat distribution. Linear mixed models were used to investigate associations between parental characteristics and adolescent BMI percentile while accounting for non-independence of observations within families. Results: Mean parental BMI was 31.37 +/- 5.67 kg/m(2), while 61.5% of parents had obesity. Among adolescents, 28.9% had BMI percentile between the 85th and 95th percentiles and 13.3% had a BMI percentile > 95th percentile. Strong family-level clustering of adolescent weight status was consistently observed across analyses, with intraclass correlation coefficients ranging from 0.716 to 0.728. In contrast, parental characteristics demonstrated limited explanatory contribution (marginal R(2) 0.028-0.044), while no isolated parental variable showed a significant association with adolescent BMI percentile. Conclusions: Strong family-level clustering of adolescent weight status was observed despite the absence of significant associations with individual parental anthropometric and metabolic characteristics, suggesting that familial obesity susceptibility may reflect shared influences extending beyond routinely measurable traits alone. FAU - Mournos, Vasilios AU - Mournos V AD - Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. FAU - Dimakopoulos, Georgios AU - Dimakopoulos G AUID- ORCID: 0000-0002-2351-7411 AD - BIOSTATS, Epirus Science and Technology Park Campus, University of Ioannina, 45110 Ioannina, Greece. FAU - Makridou, Theano AU - Makridou T AD - General Hospital of Veria, 59132 Veria, Greece. FAU - Kontotasios, Konstantinos AU - Kontotasios K AD - General Hospital of Veria, 59132 Veria, Greece. FAU - Pournaras, Dimitri J AU - Pournaras DJ AD - North Bristol NHS Trust, Bristol BS10 5NB, UK. AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 1UD, UK. FAU - le Roux, Carel W AU - le Roux CW AUID- ORCID: 0000-0001-5521-5445 AD - School of Medicine, University College Dublin, DO4 V1W8 Dublin, Ireland. FAU - Kokkinos, Alexander AU - Kokkinos A AD - First Department of Propaedeutic Internal Medicine, Medical School, National and Kapodistrian University of Athens, Laiko General Hospital, 11527 Athens, Greece. FAU - Kotsa, Kalliopi AU - Kotsa K AUID- ORCID: 0000-0003-2376-740X AD - Division of Endocrinology and Metabolism and Diabetes Center, First Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, AHEPA University Hospital, 54636 Thessaloniki, Greece. FAU - Koufakis, Theocharis AU - Koufakis T AUID- ORCID: 0000-0002-5853-1352 AD - Second Propaedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, Hippokration General Hospital, 49 Konstantinoupoleos Str., 54642 Thessaloniki, Greece. LA - eng PT - Journal Article DEP - 20260724 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13466985 OTO - NOTNLM OT - adolescent obesity OT - anthropometric characteristics OT - body mass index OT - family clustering COIS- DJP declares consulting fees from Johnson & Johnson, Novo Nordisk, Eli Lilly, Pfizer, GSK and Medtronic as well as honoraria from Johnson & Johnson, Medtronic, Sandoz and Novo Nordisk. ClR reports grants from the EU Innovative Medicine Initiative, Irish Research Council, Science Foundation Ireland, Anabio, and the Health Research Board. He serves on advisory boards and speakers panels of Abbvie, Altimmune, Amgen, Arrowhead Pharma, Astrazeneca, Boehringer Ingelheim, Eli Lily, Gila Pharmaceuticals, Herbalife, Irish Life Health, Johnson and Johnson, Keyron, Medscape, Metsera, Morphic Medical, Novo Nordisk, Nymble, Olympus, Pfizer, Rhythm Pharma, Roche, Wave, and Zealand Pharma. ClR is the Chair of the Irish Society for Nutrition and Metabolism. ClR received stock options as payment for scientific advisory board functions from Nymble. ClR provides obesity clinical care at the My Best Weight clinic and Beyond BMI clinic and is a co-owner of these clinics. AK reports research grants through his institution by Novo Nordisk Greece, Pharmaserve Lilly Greece, and ELPEN Pharma Greece. AK is on the speakers' bureau for Novo Nordisk Greece, Pharmaserve Lilly Greece, Astra Zeneca Greece, MSD Greece, Sanofi Greece, Bausch Health Greece, Ethicon Greece, Galenica Pharma Greece, Epsilon Health Greece, Winmedica Greece, and Viatris, and has consulting agreements with Novo Nordisk Greece, Pharmaserve Lilly Greece, Sanofi Greece, and Boehringer Ingelheim. TK has received honoraria for lectures from AstraZeneca, Sanofi, Boehringer Ingelheim, Pharmaserve Lilly, ELPEN, Menarini, and Novo Nordisk, for serving on advisory boards from Novo Nordisk, Roche Diagnostics, Sanofi, and Boehringer Ingelheim and has participated in sponsored studies by Eli-Lilly, AstraZeneca, and Novo Nordisk. The other authors declare that no conflicts of interest or financial relationships relevant to this article exist. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/07/24 CRDT- 2026/08/13 01:05 PHST- 2026/06/17 00:00 [received] PHST- 2026/07/14 00:00 [revised] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:05 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - jcm15155790 [pii] AID - jcm-15-05790 [pii] AID - 10.3390/jcm15155790 [doi] PST - epublish SO - J Clin Med. 2026 Jul 24;15(15):5790. doi: 10.3390/jcm15155790. PMID- 42589146 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260813 LR - 20260815 IS - 2079-7737 (Print) IS - 2079-7737 (Electronic) IS - 2079-7737 (Linking) VI - 15 IP - 15 DP - 2026 Aug 4 TI - Potential Anticancer Activity of Donkey Milk in Human Gastric Adenocarcinoma (AGS) Cell Line. LID - 10.3390/biology15151279 [doi] LID - 1279 AB - Gastric cancer (GC) remains a major global health challenge, ranking among the most lethal malignancies due to late diagnosis, high tumor heterogeneity, and limited treatment efficacy. The search for safer, nutritionally based adjuncts to conventional therapies is therefore a research priority. Donkey milk (DM), traditionally used as a hypoallergenic substitute for infants, is emerging as a functional food with remarkable bioactivity. Its composition closely resembles human milk, with high levels of bioactive proteins, a favorable polyunsaturated lipid profile, antioxidant vitamins, and immune-supportive minerals. Despite its growing nutraceutical appeal, the anticancer potential of DM in GC has not yet been explored. This study represents the first investigation of DM in human gastric adenocarcinoma (AGS) cells. Using increasing concentrations of whole DM (25-100%), a dose-dependent inhibition of cell viability and migration was observed. Mechanistic insights reveal that DM induces mitochondrial oxidative stress, disrupts cell cycle progression (S/G2 accumulation at 75%, G2 arrest at 100%), and unexpectedly triggers a pro-inflammatory gene signature suggesting stress-driven immunostimulation rather than canonical apoptosis. These findings highlight a non-classical, context-dependent cytotoxic mechanism that distinguishes DM from conventional pro-apoptotic agents. DM may represent a promising nutraceutical candidate for GC management, bridging traditional food resources with modern oncology. By inhibiting hallmark cancer traits while engaging unique immunological pathways, DM offers a sustainable, low-toxicity approach with translational potential. Future studies will focus on the characterization of active components, validation in organoid and animal models, and exploring clinical applications of DM-derived bioactive components in cancer prevention and therapy. FAU - Mazzone, Mariangela AU - Mazzone M AD - Department of Innovative Technologies in Medicine & Dentistry, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. FAU - Di Marcantonio, Maria Carmela AU - Di Marcantonio MC AUID- ORCID: 0000-0001-9308-9857 AD - Department of Innovative Technologies in Medicine & Dentistry, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. FAU - Sindaco, Maria AU - Sindaco M AD - Department of Innovative Technologies in Medicine & Dentistry, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. FAU - Fatica, Antonella AU - Fatica A AUID- ORCID: 0000-0003-0207-089X AD - Department of Agricultural, Environmental and Food Sciences, University of Molise, 86100 Campobasso, Italy. FAU - Mencarelli, Noemi AU - Mencarelli N AUID- ORCID: 0009-0009-0423-5804 AD - Department of Pharmacy, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. FAU - Gallorini, Marialucia AU - Gallorini M AUID- ORCID: 0000-0002-2283-4159 AD - Department of Pharmacy, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. FAU - Cataldi, Amelia AU - Cataldi A AD - Department of Pharmacy, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. FAU - Muraro, Raffaella AU - Muraro R AD - Department of Innovative Technologies in Medicine & Dentistry, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. FAU - Salimei, Elisabetta AU - Salimei E AUID- ORCID: 0000-0001-9945-1458 AD - Department of Agricultural, Environmental and Food Sciences, University of Molise, 86100 Campobasso, Italy. FAU - Mincione, Gabriella AU - Mincione G AUID- ORCID: 0000-0001-7127-0938 AD - Department of Innovative Technologies in Medicine & Dentistry, University "G. d'Annunzio" Chieti-Pescara, 66100 Chieti, Italy. LA - eng GR - University "G. d'Annunzio" Chieti-Pescara/ PT - Journal Article DEP - 20260804 PL - Switzerland TA - Biology (Basel) JT - Biology JID - 101587988 PMC - PMC13465012 OTO - NOTNLM OT - adjunctive therapy OT - donkey milk OT - gastric cancer OT - nutraceutical agent COIS- The authors declare no conflicts of interest. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/04 CRDT- 2026/08/13 01:04 PHST- 2026/05/04 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:04 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - biology15151279 [pii] AID - biology-15-01279 [pii] AID - 10.3390/biology15151279 [doi] PST - epublish SO - Biology (Basel). 2026 Aug 4;15(15):1279. doi: 10.3390/biology15151279. PMID- 42588200 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260827 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 15 DP - 2026 Aug 6 TI - Is Phenylalanine Restricted Dietary Treatment in Phenylketonuria Associated with Disordered Eating: A Systematic Review. LID - 10.3390/nu18152576 [doi] LID - 2576 AB - Background: In phenylketonuria (PKU), the lifelong phenylalanine (Phe)-restricted diet may contribute to altered feeding behaviours and disordered eating. The true prevalence of disordered eating and eating disorders remains uncertain, partly because validated PKU-specific assessment tools are lacking. This systematic review aimed to identify, appraise, and synthesise the evidence on disordered eating and eating disorders in PKU. Methods: Four electronic databases (PubMed, Scopus, Web of Science, and Cochrane) were searched from inception to 24 February 2026. English-language studies reporting disordered eating or eating disorders in early-diagnosed individuals with PKU managed with a Phe-restricted diet, with or without drug therapy, were included. Studies of late- or never-treated patients, pregnancy, lactation, reviews, and preclinical studies were excluded. Two independent reviewers conducted study selection and data extraction. Outcomes included the prevalence of eating disorders, disordered eating behaviours and attitudes, associated factors, and the influence of drug treatment. Findings were synthesised qualitatively, and risk of bias was assessed using the NIH Study Quality Assessment Tools. Results: Twenty-four studies (2928 individuals with PKU) met the inclusion criteria. Most were observational or survey-based. Eating disorders were reported more frequently in PKU (3-13%) than in the general population (n = 4 studies). Common disordered eating features included food neophobia (n = 5 studies), limited food variety (n = 9), food aversion or refusal (n = 5), poor appetite (n = 5), prolonged mealtimes (n = 3), negative parent-child mealtime interactions (n = 6), and specific taste preferences (n = 5). Delayed feeding skill development (n = 6 studies), reduced social eating (n = 6), gastrointestinal symptoms (n = 8), and psychological or neurodevelopmental difficulties (n = 7) were also associated with disordered eating. Early feeding difficulties frequently persisted into adulthood, and longstanding eating behaviours did not consistently improve with pharmaceutical treatment (n = 6 studies). Most studies were rated as fair quality (19/24), with common limitations including small sample sizes, lack of sample-size justification, non-validated assessment tools, and absence of randomised controlled trials. Conclusions: Current evidence suggests that people with PKU experience a greater burden of eating-related difficulties than the general population, although robust estimates of eating disorder prevalence remain lacking. Existing screening tools may misclassify treatment-related dietary behaviours as pathological or fail to identify PKU-specific eating concerns. Development of PKU-specific screening tools could support routine clinical discussions about eating behaviours and the psychosocial impact of dietary treatment, facilitating earlier identification of individuals requiring specialist eating disorder assessment. (Prospero registration: CRD42024539600). FAU - Evans, Sharon AU - Evans S AUID- ORCID: 0000-0002-7654-3621 AD - Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK. FAU - Ilgaz, Fatma AU - Ilgaz F AUID- ORCID: 0000-0002-6518-0255 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06100, Turkey. FAU - MacDonald, Anita AU - MacDonald A AD - Birmingham Children's Hospital, Steelhouse Lane, Birmingham B4 6NH, UK. LA - eng GR - Nutricia (United Kingdom)/ PT - Journal Article PT - Systematic Review DEP - 20260806 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 47E5O17Y3R (Phenylalanine) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - *Feeding and Eating Disorders/epidemiology/etiology/diet therapy MH - Feeding Behavior MH - *Phenylalanine/blood MH - *Phenylketonurias/diet therapy/complications/psychology MH - Prevalence MH - Diet, Protein-Restricted PMC - PMC13467740 OTO - NOTNLM OT - PKU OT - disordered eating OT - eating disorders OT - phenylketonuria COIS- The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. S.E. receives research funding from Vitaflo. F.I. declares no conflicts of interest in relation to this project. A.M. has received research or advisory board funding from Ajinomoto Cambrooke, Applied Pharma Research, Arla Food Ingredients, BioMarin Pharmaceutical, Galen Pharma, Ipsen Pharma, Jnana Therapeutics, MetaHealth, metaX, Nutricia, PIAM, PTC Therapeutics, and Vitaflo International. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/06 CRDT- 2026/08/13 01:02 PHST- 2026/06/22 00:00 [received] PHST- 2026/07/26 00:00 [revised] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:02 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - nu18152576 [pii] AID - nutrients-18-02576 [pii] AID - 10.3390/nu18152576 [doi] PST - epublish SO - Nutrients. 2026 Aug 6;18(15):2576. doi: 10.3390/nu18152576. PMID- 42588180 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 15 DP - 2026 Aug 5 TI - Body Composition Assessment in Pediatric Cystic Fibrosis in the Highly Effective Modulator Therapy Era-A Pilot Study. LID - 10.3390/nu18152557 [doi] LID - 2557 AB - Background/Objectives: The prevalence of obesity in cystic fibrosis (CF) has increased following the introduction of highly effective modulator therapy (HEMT). However, the impact of increased adiposity on the lung function of pediatric patients with CF (ppwCF) in the era of HEMT remains incompletely understood. Furthermore, while the body mass index (BMI) is the most commonly used nutritional marker in CF care, it has important limitations and may not accurately reflect body composition. Methods: In this cross-sectional pilot study, ppwCF aged 5-18 years completed Bioelectrical Impedance Analysis (BIA) while a subset completed a dual-energy X-ray absorptiometry (DXA) scan and spirometry. Normality was assessed using Shapiro-Wilk tests. Correlations, categorical association, agreement tests, Firth penalized logistic regression, and exploratory linear regression of continuous FEV1% predicted were used to examine relationships among anthropometric measurements, body compositions, and pulmonary function. Results: Thirty-four individuals completed study procedures (19 female (56%); mean age 9.85 (SD 3.58)). BIA and DXA-derived body fat percentages were strongly correlated, and categorical agreement was moderate (Cohen's Kappa 0.574; p-value 0.005). In age and sex-adjusted linear regression, BIA fat percentage (beta = -0.23; 95% CI, -1.09 to 0.64; p = 0.595) and DXA fat percentage (beta = -0.47; 95% CI, -2.14 to 1.21; p = 0.552) were not significantly associated with FEV1% predicted. Similarly, Firth logistic models showed no statistically significant association between the adiposity category and reduced lung function. Conclusions: BIA-derived body fat measurements correlate with DXA-derived measurements in ppwCF and demonstrate feasibility for use in routine CF clinic visits. This pilot cohort did not show a statistically significant relationship between higher adiposity and poorer pulmonary function. However, the wide confidence intervals indicate substantial uncertainty. Larger prospective studies are needed to evaluate longitudinal relationships between body composition and lung function in the HEMT era. FAU - Yavelow, Michelle AU - Yavelow M AUID- ORCID: 0000-0002-5660-8862 AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of South Florida, Tampa, FL 33612, USA. AD - Division of Pediatric Pulmonology, Department of Pediatrics, University of South Florida, Tampa, FL 33620, USA. FAU - Tsalatsanis, Athanasios AU - Tsalatsanis A AUID- ORCID: 0000-0003-3818-8283 AD - Office of Research, Research Methodology and Biostatistics Core, University of South Florida, Tampa, FL 33612, USA. FAU - Couluris, Marisa AU - Couluris M AD - Division of Pulmonology, Department of Pediatrics, University of South Florida, Tampa, FL 33612, USA. FAU - Reynolds, Danielle AU - Reynolds D AD - USF Diabetes and Endocrinology Center, Health Informatics Institute, University of South Florida, Tampa, FL 33612, USA. FAU - Khalaf, Racha T AU - Khalaf RT AUID- ORCID: 0000-0001-5010-8149 AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, University of South Florida, Tampa, FL 33612, USA. LA - eng GR - HSC-611900-22000-000000-0000000-8880153000/North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition/ PT - Journal Article DEP - 20260805 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Pilot Projects MH - Female MH - *Cystic Fibrosis/physiopathology/drug therapy/complications MH - Male MH - Adolescent MH - Cross-Sectional Studies MH - *Body Composition MH - Absorptiometry, Photon MH - Electric Impedance MH - Child, Preschool MH - Body Mass Index MH - Adiposity MH - Spirometry PMC - PMC13468600 OTO - NOTNLM OT - bioelectrical impedance analysis OT - body composition OT - body mass index OT - cystic fibrosis OT - dual-energy X-ray absorptiometry OT - fat mass OT - lung function OT - modulator therapy OT - pediatrics COIS- The authors declare no conflicts of interest. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/05 CRDT- 2026/08/13 01:02 PHST- 2026/06/26 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:02 [entrez] PHST- 2026/08/05 00:00 [pmc-release] AID - nu18152557 [pii] AID - nutrients-18-02557 [pii] AID - 10.3390/nu18152557 [doi] PST - epublish SO - Nutrients. 2026 Aug 5;18(15):2557. doi: 10.3390/nu18152557. PMID- 42588169 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 15 DP - 2026 Aug 4 TI - Plant-Derived Amino Acid-Based vs. Bovine-Derived Protein Human Milk Fortifiers in Preterm Infants at <34 Weeks' Gestation: An Open-Label Pilot Randomized Controlled Trial. LID - 10.3390/nu18152547 [doi] LID - 2547 AB - Background: Bovine milk protein-based human milk fortifiers (HMFs) are routinely used in preterm infants in low- and middle-income countries (LMICs) but are associated with potential adverse effects. Plant-derived amino acid-based HMFs are a promising alternative, but comparative data from randomized controlled trials (RCTs) are lacking. This pilot RCT aimed to evaluate the feasibility, safety, and growth outcomes of a novel plant-derived amino acid-based HMF compared to a bovine-derived whole-protein-based HMF in preterm infants at <34 weeks' gestation. Methods: In this open-label, parallel pilot RCT, preterm infants at <34 weeks' gestation were randomized to a plant-derived amino acid-based HMF (n = 66) or a bovine-derived whole-protein-based HMF (n = 70). Primary outcomes were time to reach 180 mL/kg/d enteral feeds and growth velocities to discharge and 40 weeks' postmenstrual age (PMA). Feasibility and safety were also assessed. The analysis followed an intention-to-treat approach. The trial was registered (CTRI/2025/06/089133). Results: Baseline characteristics were comparable between groups. Times to reach enteral feeds of 180 mL/kg/d did not differ (adjusted Hazard Ratio 0.93, 95% CI 0.65, 1.33; p = 0.70). In-hospital weight gain was significantly higher in the plant-derived HMF group (adjusted mean difference (aMD) 3.20 g/kg/d, 95% CI 0.46, 5.95; p = 0.02). This benefit was most evident in subgroup analyses of infants with birth weight >/=1500 g (aMD 4.47 g/kg/d, 95% CI 0.09, 8.84; p = 0.04). Length, head circumference growth, and all safety outcomes were similar between groups. Conclusions: The plant-derived amino acid-based HMF demonstrated clinical feasibility and was well-tolerated. While it was associated with better in-hospital weight gain, differences in overall macronutrient density between the formulations may account for this finding. These results are hypothesis-generating and warrant future adequately powered trials. FAU - Mudmal, Nikhil Kumar AU - Mudmal NK AD - Department of Neonatology, Ankura Hospital for Women and Children, Kukatpally, Hyderabad 500072, Telangana, India. FAU - Ramaswamy, Viraraghavan Vadakkencherry AU - Ramaswamy VV AUID- ORCID: 0000-0001-7092-3597 AD - Department of Neonatology, Ankura Hospital for Women and Children, Kukatpally, Hyderabad 500072, Telangana, India. AD - Department of Neonatology, Fernandez Foundation, Hyderguda, Hyderabad 500029, Telangana, India. FAU - Shaik, Nasreen Banu AU - Shaik NB AD - Department of Neonatology, Ankura Hospital for Women and Children, Kukatpally, Hyderabad 500072, Telangana, India. FAU - Basany, Laxman AU - Basany L AUID- ORCID: 0000-0002-4637-9007 AD - Department of Pediatrics, Ankura Hospital for Women and Children, L. B. Nagar, Hyderabad 500074, Telangana, India. AD - Department of Neonatology, Paramitha Women and Children's Hospital, L. B. Nagar, Hyderabad 500074, Telangana, India. FAU - Ali, Abid Ali Hasan AU - Ali AAH AUID- ORCID: 0009-0005-4769-7620 AD - Department of Pediatrics, Ankura Hospital for Women and Children, L. B. Nagar, Hyderabad 500074, Telangana, India. AD - Department of Pediatrics, Owaisi Hospital, Deccan College of Medical Sciences, Kanchan Bagh, Hyderabad 500058, Telangana, India. FAU - Ramya, V Sree AU - Ramya VS AD - Department of Neonatology, Ankura Hospital for Women and Children, Kukatpally, Hyderabad 500072, Telangana, India. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20260804 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Amino Acids) RN - 0 (Milk Proteins) SB - IM MH - Humans MH - Pilot Projects MH - Infant, Newborn MH - Animals MH - *Infant, Premature/growth & development MH - *Amino Acids/administration & dosage MH - Female MH - *Milk, Human/chemistry MH - *Food, Fortified MH - Gestational Age MH - Male MH - Cattle MH - *Milk Proteins/administration & dosage MH - Infant Nutritional Physiological Phenomena MH - Weight Gain MH - Enteral Nutrition MH - Feasibility Studies MH - *Infant Formula/chemistry PMC - PMC13467811 OTO - NOTNLM OT - amino acids OT - bovine HMF OT - enteral feed OT - human milk fortifier OT - neonatal nutrition OT - plant-based OT - preterm infant OT - randomized controlled trial COIS- The authors declare no conflicts of interest. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/04 CRDT- 2026/08/13 01:02 PHST- 2026/04/02 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:02 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - nu18152547 [pii] AID - nutrients-18-02547 [pii] AID - 10.3390/nu18152547 [doi] PST - epublish SO - Nutrients. 2026 Aug 4;18(15):2547. doi: 10.3390/nu18152547. PMID- 42588145 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 15 DP - 2026 Aug 4 TI - Sex-Specific Associations Between MTHFR, PPARG and ADRB3 Polymorphisms, Habitual Nutrient Intake and Metabolic Risk in Obesity: A Cross-Sectional Single-Centre Study. LID - 10.3390/nu18152522 [doi] LID - 2522 AB - Background/Objectives: Genetic polymorphisms modulate the risk of metabolic complications of obesity; yet, it remains unclear how genotype reshapes actual dietary intake and why these mechanisms differ between men and women. The aim of this study was to identify sex-specific associations of three common polymorphisms (MTHFR C677T, PPARG Pro12Ala, ADRB3 Trp64Arg) with habitual nutrient intake in patients with obesity, and to explore candidate sex-differentiated dietary hypotheses for future prospective testing. Methods: A single-centre cross-sectional study was performed in 348 patients with obesity (83 men, 265 women; BMI >/= 30 kg/m(2); age 18-60 years). Genotyping was performed by allele-specific real-time PCR from buccal swabs. Habitual intake of more than 18 nutrients was assessed using a standardised Russian software-based questionnaire. Statistical analysis included Kruskal-Wallis and Mann-Whitney tests with Bonferroni correction (threshold p < 0.017), as well as odds ratios (OR) with 95% confidence intervals. Genotype distributions were tested for Hardy-Weinberg equilibrium, and genotype-nutrient associations were additionally examined in models adjusted for age, BMI and total energy intake. Results: Three genotype-phenotype associations remained significant after Bonferroni correction. In men, the dominant-heterozygous MTHFR C/T genotype was associated with a hypercaloric dietary pattern-excess protein, fat, sodium and phosphorus-and with a high risk of arterial hypertension (OR 5.96, 95% CI 1.48-24.08; p = 0.010). The sodium load in C/T carriers was a consequence of overall overeating rather than a selective preference for salty foods. In men, ADRB3 Trp64Arg carriage was associated with massive dietary cholesterol overconsumption (+466% vs. +153% in Trp/Trp; p = 0.012), whereas in women the opposite direction was observed. The PPARG G/G genotype in women was associated with elevated alanine aminotransferase (p = 0.027), most pronounced under 40 years (p = 0.011), and is considered a marker of hepatic risk without a confirmed dietary target. In women, the MTHFR T/T homozygous genotype showed suggestive associations with excessive mono-/disaccharide intake and a tendency toward hypertension (OR 2.62, 95% CI 1.07-6.43; p = 0.035); however, these did not survive FDR correction and require independent validation. Conclusions: Genetic polymorphisms were associated with sex-specific patterns of actual dietary intake, a finding that extends current knowledge beyond biochemical risk associations. Based on these associations, we propose testable hypotheses rather than clinical recommendations: that caloric restriction (with consequent sodium reduction) in men with MTHFR C/T, cholesterol restriction in men with ADRB3 Arg64, and mono-/disaccharide restriction in women with MTHFR T/T might reduce metabolic risk; women with PPARG G/G may warrant ALT monitoring. These findings suggest that genotype-informed dietary strategies may need to be sex-specific, and that the window for intervention may be earlier in life than currently practised. However, these hypotheses require prospective interventional validation before any clinical application. FAU - Lapik, Irina A AU - Lapik IA AUID- ORCID: 0000-0002-0963-0792 AD - Federal Research Centre of Nutrition, Biotechnology and Food Safety, 2/14 Ustinsky Proyezd, Moscow 109240, Russia. FAU - Tarmaeva, Inna Yu AU - Tarmaeva IY AUID- ORCID: 0000-0001-7791-1222 AD - Federal Research Centre of Nutrition, Biotechnology and Food Safety, 2/14 Ustinsky Proyezd, Moscow 109240, Russia. FAU - Nikityuk, Dmitry B AU - Nikityuk DB AUID- ORCID: 0000-0002-4968-4517 AD - Federal Research Centre of Nutrition, Biotechnology and Food Safety, 2/14 Ustinsky Proyezd, Moscow 109240, Russia. AD - I.M. Sechenov First Moscow State Medical University (Sechenov University), Ministry of Health of the Russian Federation, Moscow 119991, Russia. LA - eng GR - FGMF-2026-0014/Federal Research Centre of Nutrition and Biotechnology/ PT - Journal Article DEP - 20260804 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (PPAR gamma) RN - 0 (Receptors, Adrenergic, beta-3) RN - 0 (ADRB3 protein, human) RN - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2)) RN - EC 1.5.1.20 (MTHFR protein, human) SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Cross-Sectional Studies MH - Middle Aged MH - *PPAR gamma/genetics MH - *Obesity/genetics MH - *Receptors, Adrenergic, beta-3/genetics MH - Adolescent MH - *Methylenetetrahydrofolate Reductase (NADPH2)/genetics MH - Young Adult MH - Sex Factors MH - *Feeding Behavior MH - Genotype MH - *Polymorphism, Genetic MH - Genetic Predisposition to Disease MH - Risk Factors MH - Diet MH - Genetic Association Studies PMC - PMC13468027 OTO - NOTNLM OT - ADRB3 Trp64Arg OT - MTHFR C677T OT - PPARG Pro12Ala OT - arterial hypertension OT - habitual dietary intake OT - metabolic dysfunction-associated steatotic liver disease OT - nutrigenetics OT - obesity OT - personalised prevention OT - sex differences COIS- The authors declare no conflicts of interest. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/04 CRDT- 2026/08/13 01:02 PHST- 2026/07/10 00:00 [received] PHST- 2026/07/28 00:00 [revised] PHST- 2026/07/29 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:02 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - nu18152522 [pii] AID - nutrients-18-02522 [pii] AID - 10.3390/nu18152522 [doi] PST - epublish SO - Nutrients. 2026 Aug 4;18(15):2522. doi: 10.3390/nu18152522. PMID- 42588129 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 15 DP - 2026 Aug 3 TI - Disordered Eating Attitudes in Hungarian Adults: Body Image, Sociocultural Media Pressures, and the Cross-Gender Athletic Ideal. LID - 10.3390/nu18152506 [doi] LID - 2506 AB - Background/Objectives: Appearance ideals are increasingly transmitted through digital media, reshaping the sociocultural context in which disordered eating develops. Central and Eastern European populations remain underrepresented in this literature. This study examined the prevalence of disordered eating attitudes in a Hungarian adult community sample and tested an integrated model of body image disturbance and media-transmitted sociocultural pressures as statistical predictors, including formal tests of mediation. Methods: Hungarian adults (N = 675; 70.8% female; aged 16-81 years, M = 44.09) completed the Eating Attitudes Test-26 (EAT-26), the Body Attitude Test (BAT), and the Sociocultural Attitudes Towards Appearance Questionnaire-3 (SATAQ-3) in an online survey; body mass index (BMI) was calculated from self-reported height and weight. All instruments demonstrated good to excellent internal consistency in the present sample (Cronbach's alpha = 0.84-0.93). Results: One in five participants (20.7%) scored at or above the EAT-26 clinical cut-off, with elevated rates at both extremes of the BMI spectrum (underweight: 30.0%; obese: 28.4%). Women scored higher than men on the EAT-26 (d = -0.59), BAT (d = -0.80), and three SATAQ-3 subscales; no gender difference emerged for athletic-ideal internalisation (d = -0.02), consistent with a cross-gender athletic ideal. The predictor set accounted for 40.5% of the variance in EAT-26 scores; BAT was the dominant predictor (beta = 0.61), while SATAQ-3 Athletic retained a direct path (beta = 0.08), and the remaining media-influence subscales lost significance once body image was controlled. A binary logistic regression using these predictors correctly classified 83.6% of participants (Nagelkerke R(2) = 0.35), with BAT and athletic-ideal internalisation again the only significant predictors of clinical-range classification. Bootstrapped mediation analyses confirmed that the associations between sociocultural influences and disordered eating attitudes were largely mediated by body image disturbance; only athletic-ideal internalisation retained a significant direct association (partial mediation). Conclusions: Body image disturbance constitutes the proximal core of disordered eating attitudes, whereas internalisation of the athletic ideal shows a small independent association, with implications for screening and prevention across the adult lifespan. FAU - Efthyvoulou, Lina AU - Efthyvoulou L AUID- ORCID: 0000-0003-0297-8777 AD - Department of Psychology, Neapolis University Pafos, 8042 Paphos, Cyprus. FAU - Dergez, Teodora AU - Dergez T AD - Faculty of Health Sciences, University of Pecs, 7622 Pecs, Hungary. FAU - Koushiou, Maria AU - Koushiou M AUID- ORCID: 0000-0002-5844-9906 AD - Department of Social Sciences, University of Nicosia, 2417 Nicosia, Cyprus. FAU - Argyrides, Marios AU - Argyrides M AUID- ORCID: 0000-0002-9936-7229 AD - Department of Psychology, Neapolis University Pafos, 8042 Paphos, Cyprus. LA - eng PT - Journal Article DEP - 20260803 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - Hungarian people SB - IM MH - Adolescent MH - Adult MH - Aged MH - Aged, 80 and over MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Body Image/psychology MH - Body Mass Index MH - Digital Media MH - Eastern European People MH - *Feeding and Eating Disorders/psychology/epidemiology MH - Hungary/epidemiology MH - Media Exposure MH - Prevalence MH - Sex Factors MH - Surveys and Questionnaires PMC - PMC13468281 OTO - NOTNLM OT - athletic ideal OT - body image OT - disordered eating OT - eating disorders OT - fitspiration OT - internalisation OT - mental health OT - nutrition OT - public health OT - social media COIS- M.A. serves as Guest Editor and M.K. as Guest Editor Assistant of the Special Issue "Eating Disorders, Body Image and Mental Health in a Digital World" of Nutrients; the manuscript underwent the journal's standard editorial process, handled independently of the Guest Editors. The authors declare no other conflicts of interest. EDAT- 2026/08/13 05:35 MHDA- 2026/08/13 05:36 PMCR- 2026/08/03 CRDT- 2026/08/13 01:02 PHST- 2026/07/02 00:00 [received] PHST- 2026/07/18 00:00 [revised] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/08/13 05:36 [medline] PHST- 2026/08/13 05:35 [pubmed] PHST- 2026/08/13 01:02 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - nu18152506 [pii] AID - nutrients-18-02506 [pii] AID - 10.3390/nu18152506 [doi] PST - epublish SO - Nutrients. 2026 Aug 3;18(15):2506. doi: 10.3390/nu18152506. PMID- 42588098 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 15 DP - 2026 Jul 30 TI - Effects of Three Consecutive Days of Diurnal Intermittent Fasting on Cognitive Function, Psychomotor Vigilance, and Sleep Quality in Adolescent Male Soccer Players: A Quasi-Experimental Parallel-Group Study. LID - 10.3390/nu18152475 [doi] LID - 2475 AB - Aim: While voluntary Islamic intermittent fasting (IF) of three consecutive days (mimicking practices such as Ayyam al-Bid) may be observed by Muslim athletes, its short-term effects on cognitive function and sleep quality in adolescent team-sport athletes remain unexamined. This study investigated the impact of three successive days of dawn-to-sunset IF on memory, attention, psychomotor vigilance, and subjective sleep quality in young male soccer players. Methods: A quasi-experimental, parallel-group design was employed. Thirty-five male soccer players (age: 15.6 +/- 0.8 years; body mass: 55.07 +/- 6.53 kg) were allocated to an IF group (n = 17) or a non-fasting control group (n = 18). The fasting protocol comprised approximately 14 consecutive hours of complete food and fluid abstinence per day (from 04:40 to 18:36, with daily variations of -3 min for the dawn and +2 min for the sunset, local time). Cognitive function was assessed using the CogniFit Cognitive Assessment Battery (CAB) and the Psychomotor Vigilance Test (PVT), and subjective well-being was quantified via the Hooper Index. Both assessment sessions were conducted between 14:00 and 17:00 to control for diurnal variation. Results: The Group x Time interaction for single-item subjective sleep quality reached nominal significance at the unadjusted threshold (Z = 2.18, p = 0.029, r = 0.37) but did not survive Bonferroni correction for the four Hooper Index comparisons (alpha = 0.0125); this result is therefore interpreted as hypothesis-generating only, reflecting a within-group deterioration in the control group (p < 0.05) alongside a non-significant marginal improvement in the fasting group. No statistically significant Group x Time interaction was detected for any memory subdomain (all p >/= 0.419, r 0.176, r 0.192, eta(2)p/r .073). Results support equivalence and feasibility of the remote APS for school-aged children with and without developmental differences. Recommendations for administration are discussed. FAU - Gordon, Rachel A AU - Gordon RA AUID- ORCID: 0000-0001-7566-6868 AD - Case Western Reserve University, Cleveland, OH. FAU - Doernberg, Ellen A AU - Doernberg EA AD - Boston Children's Hospital, Boston, MA. FAU - Dimitropoulos, Anastasia AU - Dimitropoulos A AD - Case Western Reserve University, Cleveland, OH. FAU - Russ, Sandra W AU - Russ SW AD - Case Western Reserve University, Cleveland, OH. LA - eng PT - Journal Article DEP - 20260225 PL - United States TA - Am J Intellect Dev Disabil JT - American journal on intellectual and developmental disabilities JID - 101492916 SB - IM MH - Humans MH - Child MH - Female MH - *Play and Playthings MH - *Autism Spectrum Disorder/diagnosis/physiopathology MH - Male MH - *Prader-Willi Syndrome/diagnosis/physiopathology MH - Telemedicine MH - *Affect/physiology MH - *Psychometrics/instrumentation OTO - NOTNLM OT - Affect in Play Scale OT - Prader-Willi Syndrome OT - Pretend play OT - assessment OT - autism spectrum disorder OT - telehealth EDAT- 2026/08/12 17:35 MHDA- 2026/08/12 17:36 CRDT- 2026/08/12 11:25 PHST- 2026/08/12 17:36 [medline] PHST- 2026/08/12 17:35 [pubmed] PHST- 2026/08/12 11:25 [entrez] AID - 10.1080/19447558.2026.2615614 [doi] PST - ppublish SO - Am J Intellect Dev Disabil. 2026;131(3):204-211. doi: 10.1080/19447558.2026.2615614. Epub 2026 Feb 25. PMID- 42583817 OWN - NLM STAT- MEDLINE DCOM- 20260812 LR - 20260909 IS - 2054-1058 (Electronic) IS - 2054-1058 (Linking) VI - 13 IP - 8 DP - 2026 Aug TI - Prevalence of Kinesiophobia and Associated Factors Among Patients After Percutaneous Coronary Intervention: A Multicenter Cross-Sectional Study. PG - e70748 LID - 10.1002/nop2.70748 [doi] LID - e70748 AB - AIM: To investigate the prevalence and associated factors of kinesiophobia after percutaneous coronary intervention (PCI). DESIGN: A multicenter cross-sectional study. METHODS: We collected data of post-PCI patients who were recruited via convenience sampling from cardiology departments of eight tertiary hospitals between 1 November 2022 and 31 December 2023. Kinesiophobia was assessed by the Tampa Scale for Kinesiophobia Heart (TSK-SV Heart). Exercise self-efficacy, depression, anxiety, stress, and social support were evaluated by validated instruments. Participants' demographic and objective socioeconomic factors were also collected. Binary logistic regression analysis was conducted to identify the associated factors of kinesiophobia. RESULTS: Of 1145 recruited patients, 970 (84.72%) provided complete data and were included in the final analysis, of which 780 (80.41%) exhibited kinesiophobia. Factors significantly associated with kinesiophobia in the binary logistic regression analysis included: single status (vs. married: OR = 0.42, 95% CI: 0.22-0.79, p = 0.008), retired (vs. freelancers: OR = 1.89, 95% CI: 1.22-2.93, p = 0.004), had beyond 3 children (vs. 1 child: OR = 0.68, 95% CI: 0.46-0.99, p = 0.045), generally familiar with illness (vs. not familiar: OR = 2.00, 95% CI: 1.37-2.93, p < 0.001), comorbid hypertension (vs. no hypertension: OR = 1.49, 95% CI: 1.05-2.13, p = 0.028), participated in cardiac rehabilitation (vs. did not participate: OR = 1.52, 95% CI: 1.06-2.19, p = 0.023), moderate physical activity (vs. low: OR = 0.64, 95% CI: 0.42-0.97, p = 0.034), and high physical activity (vs. low: OR = 0.40, 95% CI: 0.25-0.65, p < 0.001) were significantly associated with kinesiophobia occurrence (p < 0.05). For each one-point increase in stress, anxiety, and objective support, the odds of kinesiophobia increased by 9% (OR = 1.09, 95% CI: 1.02-1.15, p = 0.008), 21% (OR = 1.21, 95% CI: 1.12-1.29, p < 0.001), and 9% (OR = 1.09, 95% CI: 1.01-1.19, p = 0.027), respectively. For each one-point increase in depression and SEE-C score, the odds of kinesiophobia decreased by 11% (OR = 0.89, 95% CI: 0.84-0.96, p = 0.001) and 1% (OR = 0.99, 95% CI: 0.98-0.99, p < 0.001), respectively. CONCLUSION: Kinesiophobia is highly prevalent among post-PCI patients. Identified associated factors include marital status, occupational status, number of children, illness familiarity, hypertension comorbidity, cardiac rehabilitation participation, physical activity level, levels of psychological distress, objective support, and exercise self-efficacy. These findings highlight potential targets for intervention. IMPLICATIONS FOR THE PROFESSION AND PATIENT CARE: Nurses should integrate routine kinesiophobia screening using the TSK-SV Heart scale into post-PCI assessment protocols. Risk-stratified screening should prioritize married or retired patients, those with fewer than three children, individuals with hypertension, and those with low baseline physical activity. For patients with low exercise self-efficacy, nurses can use motivational interviewing; for those with elevated anxiety or stress, collaborative cognitive-behavioural therapy is recommended. These nursing actions can reduce kinesiophobia and improve cardiac rehabilitation adherence. IMPACT: What problem did the study address? Kinesiophobia is a common but under-recognized barrier to cardiac rehabilitation in post-PCI patients, yet its prevalence and modifiable factors in Chinese populations remain poorly understood. What were the main findings? The prevalence of kinesiophobia was 80.41%. Independent associated factors included marital status, retirement, number of children, illness familiarity, hypertension, cardiac rehabilitation participation, physical activity level, anxiety, stress, depression, objective support, and exercise self-efficacy. Where and on whom will the research have an impact? The findings directly inform cardiac nursing practice in China and similar settings, enabling nurses to identify high-risk patients and implement targeted psychosocial interventions. REPORTING METHOD: This study adhered to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guideline for cross-sectional observational studies. PATIENT OR PUBLIC CONTRIBUTION: No patient or public contributed to the design, conduct, analysis, or interpretation of this study. TRIAL REGISTRATION: This observational study was registered in the Chinese Clinical Trial Registry (No. ChiCTR2300070396; https://www.chictr.org.cn/). CI - (c) 2026 The Author(s). Nursing Open published by John Wiley & Sons Ltd. FAU - Wang, Chunyuan AU - Wang C AD - Interventional Operation Center, Guangzhou First People's Hospital, Guangzhou, China. FAU - Hou, Xiaoqin AU - Hou X AD - Interventional Operation Center, Guangzhou First People's Hospital, Guangzhou, China. FAU - Zhang, Pian AU - Zhang P AD - Interventional Operation Center, Guangzhou First People's Hospital, Guangzhou, China. FAU - Liu, Caiyang AU - Liu C AD - Interventional Operation Center, Guangzhou First People's Hospital, Guangzhou, China. FAU - Yang, Yi AU - Yang Y AUID- ORCID: 0009-0000-2994-8346 AD - Department of Cardiology, Guangdong Provincial People's Hospital, Guangzhou, China. FAU - Zhao, Zhenhua AU - Zhao Z AD - Department of Cardiology, Guangdong Second Provincial People's Hospital, Guangzhou, China. FAU - Jiang, Weijun AU - Jiang W AD - Interventional Operating Room, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China. FAU - Su, Guanfu AU - Su G AD - Department of Cardiology, Huizhou Central People's Hospital, Huizhou, China. FAU - Jiang, Xiaofang AU - Jiang X AUID- ORCID: 0009-0003-6556-3226 AD - Department of Cardiology, Northern Guangdong People's Hospital, Shaoguan, China. FAU - Lin, Lijuan AU - Lin L AD - Department of Cardiology, Meizhou People's Hospital, Meizhou, China. FAU - Ning, Libing AU - Ning L AD - Department of Cardiology, The Seventh Affiliated Hospital of Sun Yat-sen University, Shenzhen, China. FAU - Lin, Lixia AU - Lin L AD - Department of Cardiology, Guangdong Provincial People's Hospital, Guangzhou, China. FAU - Zhan, Lechang AU - Zhan L AD - Department of Rehabilitation, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Zhan, Jie AU - Zhan J AUID- ORCID: 0000-0003-0220-3699 AD - Department of Rehabilitation, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. LA - eng GR - 2023HL11/the Hongmian project of GuangZhou First People's Hospital/ PT - Journal Article PT - Multicenter Study PT - Observational Study PL - United States TA - Nurs Open JT - Nursing open JID - 101675107 SB - IM MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Anxiety/psychology MH - Cross-Sectional Studies MH - *Kinesiophobia/epidemiology MH - *Percutaneous Coronary Intervention/psychology/adverse effects MH - Prevalence MH - Risk Factors MH - Surveys and Questionnaires PMC - PMC13463317 OTO - NOTNLM OT - exercise adherence OT - kinesiophobia OT - nursing assessment OT - percutaneous coronary intervention OT - psychological assessment OT - rehabilitation nursing COIS- Statistical Declaration Statement: The authors confirm that all statistical analyses in this study were performed appropriately. Data analysis was conducted using SPSSAU (version 26.0, https://www.spssau.com). The choice of statistical methods was guided by the nature of the data and the study objectives. Normality of continuous variables was assessed using the Shapiro-Wilk test, leading to the use of Mann-Whitney U test and Spearman correlation where appropriate. Categorical variables were analysed using the chi-square test. Binary logistic regression with stepwise selection was used to identify independent predictors of kinesiophobia, with results reported as odds ratios (ORs) and 95% confidence intervals (CIs). Multicollinearity was assessed using the variance inflation factor (VIF) and tolerance. Tolerance values > 0.1 (or VIF < 10) indicated no significant multicollinearity. Model fit was evaluated using the Hosmer-Lemeshow goodness-of-fit test. A non-significant p value (> 0.05) indicated adequate model fit. The overall model significance was tested using the likelihood ratio test comparing the final model to the null model. A two-sided p < 0.05 was considered statistically significant. AI Tools Acknowledgement: No generative artificial intelligence tools were used in the preparation of this manuscript. All writing, analysis, and interpretation were performed by the authors. The authors declare no conflicts of interest. EDAT- 2026/08/12 11:37 MHDA- 2026/08/12 11:38 PMCR- 2026/08/12 CRDT- 2026/08/12 07:32 PHST- 2026/07/30 00:00 [revised] PHST- 2024/12/24 00:00 [received] PHST- 2026/08/03 00:00 [accepted] PHST- 2026/08/12 11:38 [medline] PHST- 2026/08/12 11:37 [pubmed] PHST- 2026/08/12 07:32 [entrez] PHST- 2026/08/12 00:00 [pmc-release] AID - NOP270748 [pii] AID - 10.1002/nop2.70748 [doi] PST - ppublish SO - Nurs Open. 2026 Aug;13(8):e70748. doi: 10.1002/nop2.70748. PMID- 42582380 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260812 LR - 20260813 IS - 2673-3153 (Electronic) IS - 2673-3153 (Print) IS - 2673-3153 (Linking) VI - 8 DP - 2026 TI - Development and temporal validation of a prediction model for live birth in infertile women with polyendocrine metabolic ovarian syndrome: a retrospective cohort study. PG - 1891181 LID - 10.3389/frph.2026.1891181 [doi] LID - 1891181 AB - OBJECTIVE: To develop and temporally validate a prediction model for delivery of a live-born infant within 365 days after the initial infertility consultation in infertile women with a documented diagnosis of polycystic ovary syndrome (PCOS), which was renamed in 2026 as polyendocrine metabolic ovarian syndrome (PMOS), using routine clinical and basal endocrine variables. METHODS: This single-center retrospective cohort study included infertile women with a documented diagnosis of PCOS and an index date between December 1, 2021, and December 31, 2024. The index date was the first infertility consultation at which baseline clinical assessment and basal endocrine testing were completed. Patients were assigned to the development cohort (December 1, 2021-December 31, 2023) or the same-center temporal validation cohort (January 1-December 31, 2024). Outcome ascertainment ended on December 31, 2025. Multivariable logistic regression was used to predict delivery of a live-born infant within 365 days under routine individualized care. RESULTS: Among 610 women, 389 were in the development cohort and 221 in the temporal validation cohort. Live-birth proportions within 365 days were 44.7% and 44.3%, respectively. Complete-case model development and validation included 349 and 203 women, respectively. The final model included age, body mass index, infertility duration, gravidity, luteinizing hormone/follicle-stimulating hormone ratio, tubal/pelvic factors, and uterine factors. Older age (OR = 0.91, 95% CI: 0.85-0.98), higher body mass index (OR = 0.92, 95% CI: 0.86-0.98), longer infertility duration (OR = 0.85, 95% CI: 0.77-0.94), higher luteinizing hormone/follicle-stimulating hormone ratio (OR = 0.71, 95% CI: 0.55-0.91), and uterine factors (OR = 0.37, 95% CI: 0.15-0.80) were associated with lower live-birth probability. The AUCs were 0.735 and 0.738, and the Brier scores were 0.208 and 0.205, respectively. CONCLUSION: This model showed moderate discrimination and acceptable calibration for predicting delivery of a live-born infant within 365 days after initial infertility consultation. Multicenter external validation and impact studies are needed before broader clinical application. CI - (c) 2026 Liu, Wang, Lu, Jia, Geng, Cao, Han and Zhou. FAU - Liu, Peng AU - Liu P AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. FAU - Wang, Shuhong AU - Wang S AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. FAU - Lu, Yubo AU - Lu Y AD - School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai, China. FAU - Jia, Hanbing AU - Jia H AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. FAU - Geng, Yue AU - Geng Y AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. FAU - Cao, Cuijuan AU - Cao C AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. FAU - Han, Le AU - Han L AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. FAU - Zhou, Yingjie AU - Zhou Y AD - Department of Clinical Laboratory, Hebei Reproductive Health Hospital, Shijiazhuang, Hebei, China. LA - eng PT - Journal Article DEP - 20260728 PL - Switzerland TA - Front Reprod Health JT - Frontiers in reproductive health JID - 9918230899006676 PMC - PMC13457464 OTO - NOTNLM OT - infertility OT - live birth OT - nomogram OT - polycystic ovary syndrome OT - polyendocrine metabolic ovarian syndrome OT - prediction model OT - temporal validation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/12 11:38 MHDA- 2026/08/12 11:39 PMCR- 2026/07/28 CRDT- 2026/08/12 06:04 PHST- 2026/05/26 00:00 [received] PHST- 2026/07/09 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/08/12 11:39 [medline] PHST- 2026/08/12 11:38 [pubmed] PHST- 2026/08/12 06:04 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - 10.3389/frph.2026.1891181 [doi] PST - epublish SO - Front Reprod Health. 2026 Jul 28;8:1891181. doi: 10.3389/frph.2026.1891181. eCollection 2026. PMID- 42582369 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260812 LR - 20260813 IS - 0972-5229 (Print) IS - 1998-359X (Electronic) IS - 0972-5229 (Linking) VI - 30 IP - 7 DP - 2026 Jul TI - Change in Nutritional Status of Children in the Pediatric Intensive Care Unit over First 14 Days: A Prospective Cohort Study. PG - 595-600 LID - 10.5005/jp-journals-10071-25227 [doi] AB - BACKGROUND AND AIMS: We studied changes in nutritional status from baseline, as measured by serial skinfold thickness measurements and their association with patient factors, disease factors, and biochemical factors, as well as time to the start of enteral feeds. PATIENTS AND METHODS: We enrolled 50 consecutive children aged 2-5 years from the pediatric intensive care unit (PICU) of a public sector hospital in India between 14 February, 2024 and 31 August, 2024. Baseline demographic and clinical data were recorded. Serial anthropometric parameters were measured for all children at the time of admission (+4 hours), day 3, day 7, and day 14 or at hospital discharge, if earlier. We used the World Health Organization (WHO) growth charts to interpret the anthropometric data. RESULTS: Of the 50 children enrolled (mean age 3.17 +/- 1.22 years; 46% females), 58% were underweight, 52% had wasting, and 52% had short stature at admission. Only 10% children (n = 5) had triceps skinfold thickness for age <-2 standard deviation (SD) at baseline. 32 (64%) of the children demonstrated a reduction in triceps skinfold thickness, 72% (n = 36) experienced weight loss, and 58% (n = 29) showed a decrease in mid-upper arm circumference (MUAC). However, we did not find a statistically significant association of change in triceps skinfold thickness with age, severity of illness, outcome, duration of stay, and early start of enteral feeds. CONCLUSION: This study shows the feasibility of skinfold calipers as a serial monitoring tool in the PICU. Nutritional status worsens during the initial 2 weeks of PICU stay, despite early enteral feeding policies. CI - Copyright (c) 2026; The Author(s). FAU - Loyi, Morik AU - Loyi M AUID- ORCID: 0009-0002-4956-3392 AD - Department of Pediatrics, Maulana Azad Medical College and Lok Nayak Hospital (Delhi University), New Delhi, India. FAU - Mishra, Devendra AU - Mishra D AUID- ORCID: 0000-0002-6810-3095 AD - Department of Pediatrics, Maulana Azad Medical College and Lok Nayak Hospital (Delhi University), New Delhi, India. FAU - Jhamb, Urmila AU - Jhamb U AUID- ORCID: 0000-0003-1734-3504 AD - Department of Pediatrics, Maulana Azad Medical College and Lok Nayak Hospital (Delhi University), New Delhi, India. FAU - Saxena, Romit AU - Saxena R AUID- ORCID: 0000-0002-8518-5504 AD - Department of Pediatrics, Maulana Azad Medical College and Lok Nayak Hospital (Delhi University), New Delhi, India. LA - eng PT - Journal Article DEP - 20260721 PL - India TA - Indian J Crit Care Med JT - Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine JID - 101208863 PMC - PMC13457648 OTO - NOTNLM OT - Critical illness OT - Enteral feeding OT - Malnutrition OT - Outcome OT - Triceps skinfold thickness OT - Wasting COIS- None.Source of support: Nil Conflict of interest: NoneConflict of interest: None EDAT- 2026/08/12 11:38 MHDA- 2026/08/12 11:39 PMCR- 2026/07/01 CRDT- 2026/08/12 06:03 PHST- 2025/06/04 00:00 [received] PHST- 2026/06/07 00:00 [accepted] PHST- 2026/08/12 11:39 [medline] PHST- 2026/08/12 11:38 [pubmed] PHST- 2026/08/12 06:03 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 10.5005/jp-journals-10071-25227 [doi] PST - ppublish SO - Indian J Crit Care Med. 2026 Jul;30(7):595-600. doi: 10.5005/jp-journals-10071-25227. Epub 2026 Jul 21. PMID- 42582176 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260812 LR - 20260813 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Competition and training load of high-level competitive non-motorised surface water sports athletes: a scoping review of athlete monitoring methodology. PG - 1811408 LID - 10.3389/fspor.2026.1811408 [doi] LID - 1811408 AB - INTRODUCTION: Monitoring athletes during training and competition is necessary to gather information on athletes' fitness and fatigue to prescribe training loads more precisely. The goal of this process is to improve performance and reduce injury risk. This scoping review aimed to examine and map existing research on monitoring methods for high-level athletes in non-motorised surface water sports, thereby identifying the most commonly used method(s) in these competitive sports and guiding future research. METHODS: The Joanna Briggs Institute's scoping review framework served as the guide to provide clarity and rigour in the review. Studies included in this review were published in English in peer-reviewed journals and were identified through a systematic search of four databases: Academic Search Premier, Google Scholar, SPORTDiscus and SpringerLink. The final search of these databases was conducted in August 2025. RESULTS: Twenty-two papers were deemed relevant for inclusion in the final review. Methodologically, the literature converged on heart rate-based internal load metrics (71%, 15/21) and GPS-derived external load metrics (47%, 8/19), however these are imported from land- and ergometer-based environments and are not yet validated against the environmental load that defines non-motorised surface water sports. DISCUSSION: Practically, until environment-adjusted metrics exist, all metrics should be interpreted within environmental contexts. Furthermore, the review highlights the need to increase the use of athlete monitoring methods, particularly for youth and females, and in sports such as sailing and canoeing. Future research should aim to develop ecologically valid monitoring methods in a range of non-motorised surface water sports. CI - (c) 2026 Walker, Lambert and Welman. FAU - Walker, Claire Nancy AU - Walker CN AD - Division of Movement Science and Exercise Therapy, Department of Exercise, Sport and Lifestyle Medicine, Faculty of Medicine and Health Science, Stellenbosch University, Stellenbosch, South Africa. FAU - Lambert, Michael AU - Lambert M AD - Division of Physiological Science and Health Through Physical Activity, Lifestyle and Sport, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. FAU - Welman, Karen Estelle AU - Welman KE AD - Division of Movement Science and Exercise Therapy, Department of Exercise, Sport and Lifestyle Medicine, Faculty of Medicine and Health Science, Stellenbosch University, Stellenbosch, South Africa. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260728 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13457226 OTO - NOTNLM OT - athlete monitoring OT - competition load OT - non-motorised surface water sport OT - scoping review OT - training load COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/12 11:38 MHDA- 2026/08/12 11:39 PMCR- 2026/07/28 CRDT- 2026/08/12 05:41 PHST- 2026/02/14 00:00 [received] PHST- 2026/06/30 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/08/12 11:39 [medline] PHST- 2026/08/12 11:38 [pubmed] PHST- 2026/08/12 05:41 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - 10.3389/fspor.2026.1811408 [doi] PST - epublish SO - Front Sports Act Living. 2026 Jul 28;8:1811408. doi: 10.3389/fspor.2026.1811408. eCollection 2026. PMID- 42581838 OWN - NLM STAT- MEDLINE DCOM- 20260812 LR - 20260909 IS - 1478-5153 (Electronic) IS - 1362-1017 (Print) IS - 1362-1017 (Linking) VI - 31 IP - 5 DP - 2026 Sep TI - Sleep Characteristics of Parents of Children in the Paediatric Intensive Care Unit: A Pilot Observational Study. PG - e70609 LID - 10.1111/nicc.70609 [doi] LID - e70609 AB - BACKGROUND: Parents of children hospitalised in the paediatric intensive care unit (PICU) exhibit poor sleep quality due to stress from the child's illness, uncertainty and changing family roles. AIMS: We aimed to utilise two subjective and one objective measurement to examine sleep characteristics among parents of children in the PICU and explore possible contributing factors, including parental stress. STUDY DESIGN: This observational pilot study assessed parents of children in the PICU in South Korea using the Pittsburgh Sleep Quality Index (PSQI) and the General Sleep Disturbance Scale (GSDS). Sleep-related parameters were measured for 3 nights using an actigraph. The Parental Stress Scale:PICU was used to assess stress levels. RESULTS: A total of 18 parents participated in the study. Sleep quality was poor on both PSQI and GSDS, and their total sleep scores did not correlate with any actigraphy parameter. Only the GSDS daytime function subscale suggested associations with sleep efficiency (p = 0.04) and wake after sleep onset (p = 0.04). Parents averaged 5.73 h of sleep per night, with a sleep efficiency of 86.8%. The most prominent stressors were changes in parental roles and the child's appearance, while stress levels were not significantly related to sleep. No single factor influenced sleep across all tools; rather, different factors, including parent characteristics and length of stay, exerted an influence that varied by measurement tool. All participants completed the actigraphy protocol, proving its feasibility. CONCLUSIONS: Factors influencing parental sleep varied by measurement tool, suggesting that subjective and objective sleep measures may capture different aspects of sleep in parents. As this was a pilot study for hypothesis generation and feasibility, the findings require further validation in larger-scale studies. RELEVANCE TO CLINICAL PRACTICE: A comprehensive assessment that integrates objective and subjective sleep measures could improve the understanding of sleep among PICU parents and inform effective support strategies. CI - (c) 2026 The Author(s). Nursing in Critical Care published by John Wiley & Sons Ltd on behalf of British Association of Critical Care Nurses. FAU - Lee, Hyejung AU - Lee H AUID- ORCID: 0000-0001-9357-0640 AD - Mo-Im Kim Nursing Research Institute, College of Nursing, Yonsei University, Seoul, South Korea. FAU - Lee, Hyeryeong AU - Lee H AUID- ORCID: 0000-0002-3043-6767 AD - College of Nursing, The Ohio State University, Columbus, Ohio, USA. AD - College of Nursing, Yonsei University, Seoul, South Korea. FAU - Jung, Sanghun AU - Jung S AD - Severance Hospital, Yonsei University Health System, Seoul, USA South Korea. FAU - Park, Ai Soon AU - Park AS AD - Severance Hospital, Yonsei University Health System, Seoul, USA South Korea. LA - eng GR - Yonsei University College of Nursing/ PT - Journal Article PT - Observational Study PL - England TA - Nurs Crit Care JT - Nursing in critical care JID - 9808649 SB - IM MH - Humans MH - Pilot Projects MH - *Intensive Care Units, Pediatric MH - Female MH - *Parents/psychology MH - Male MH - Child MH - Republic of Korea MH - *Sleep Quality MH - *Stress, Psychological MH - Child, Preschool MH - Actigraphy MH - *Sleep Wake Disorders MH - Adult MH - Sleep Duration MH - *Sleep/physiology MH - Infant PMC - PMC13463211 OTO - NOTNLM OT - hospitalised child OT - paediatric intensive care unit OT - parents OT - sleep quality COIS- The authors declare no conflicts of interest. EDAT- 2026/08/12 11:38 MHDA- 2026/08/12 11:39 PMCR- 2026/08/12 CRDT- 2026/08/12 05:05 PHST- 2026/06/22 00:00 [revised] PHST- 2026/04/11 00:00 [received] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/12 11:39 [medline] PHST- 2026/08/12 11:38 [pubmed] PHST- 2026/08/12 05:05 [entrez] PHST- 2026/08/12 00:00 [pmc-release] AID - NICC70609 [pii] AID - 10.1111/nicc.70609 [doi] PST - ppublish SO - Nurs Crit Care. 2026 Sep;31(5):e70609. doi: 10.1111/nicc.70609. PMID- 42580066 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260909 IS - 1873-7072 (Electronic) IS - 0308-8146 (Linking) VI - 525 IP - Pt 4 DP - 2026 Oct 1 TI - Evaluation of glycoalkaloids and their aglycones in vegetable-based baby foods using a validated mesostructured silica-based MSPD protocol assisted by bead homogenization and UHPLC-MS/MS. PG - 150709 LID - S0308-8146(26)02869-4 [pii] LID - 10.1016/j.foodchem.2026.150709 [doi] AB - Glycoalkaloids (GAs) are a food safety concern in Solanaceae-derived products, but their occurrence in baby foods remains poorly documented. This study presents a sensitive, sustainable methodology for simultaneous determination of GAs and their aglycones in vegetable-based baby foods containing potato, eggplant, or tomato. Comparative evaluation of miniaturized ultrasound assisted (UA-MSPD), vortex assisted (VA-MSPD), and homogenizer assisted (HA-MSPD) matrix solid phase dispersion identified HA-MSPD as the most efficient strategy. Performance was improved using mesostructured silica MSU-2. Box-Behnken design optimized a rapid 30 s protocol with 5 mg sorbent, 125 mg sample, and 1 mL acidified methanol for simultaneous extraction and clean-up. The method exhibited excellent greenness (AGREEprep: 0.68) and reliable quantification of six GAs and two aglycones. Application to 23 commercial samples revealed total GAs up to 18 mg/kg, highlighting variability linked to raw material quality and underscoring the need for systematic monitoring of Solanaceae ingredients in infant foods. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Martinez-Garcia, Isabel AU - Martinez-Garcia I AD - Departamento de Tecnologia Quimica y Ambiental, E.S.C.E.T, Universidad Rey Juan Carlos, C/ Tulipan s/n, 28933 Mostoles, Madrid, Spain; Instituto de Investigacion de Tecnologias para la Sostenibilidad, Universidad Rey Juan Carlos, C/ Tulipan s/n, 28933 Mostoles, Madrid, Spain. FAU - Soto-Rangel, Lacey AU - Soto-Rangel L AD - Departamento de Tecnologia Quimica y Ambiental, E.S.C.E.T, Universidad Rey Juan Carlos, C/ Tulipan s/n, 28933 Mostoles, Madrid, Spain; Departamento de Quimica Analitica, FACINET Universidad de Panama, Panama 3366, Panama. FAU - Perez-Quintanilla, Damian AU - Perez-Quintanilla D AD - Departamento de Tecnologia Quimica y Ambiental, E.S.C.E.T, Universidad Rey Juan Carlos, C/ Tulipan s/n, 28933 Mostoles, Madrid, Spain. FAU - Morante-Zarcero, Sonia AU - Morante-Zarcero S AD - Departamento de Tecnologia Quimica y Ambiental, E.S.C.E.T, Universidad Rey Juan Carlos, C/ Tulipan s/n, 28933 Mostoles, Madrid, Spain. Electronic address: sonia.morante@urjc.es. FAU - Sierra, Isabel AU - Sierra I AD - Departamento de Tecnologia Quimica y Ambiental, E.S.C.E.T, Universidad Rey Juan Carlos, C/ Tulipan s/n, 28933 Mostoles, Madrid, Spain; Instituto de Investigacion de Tecnologias para la Sostenibilidad, Universidad Rey Juan Carlos, C/ Tulipan s/n, 28933 Mostoles, Madrid, Spain. Electronic address: isabel.sierra@urjc.es. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20260806 PL - England TA - Food Chem JT - Food chemistry JID - 7702639 RN - 0 (Alkaloids) RN - 7631-86-9 (Silicon Dioxide) SB - IM MH - *Infant Food/analysis MH - *Vegetables/chemistry MH - *Food Contamination/analysis MH - Chromatography, High Pressure Liquid/methods MH - *Tandem Mass Spectrometry/methods MH - *Alkaloids/isolation & purification/chemistry/analysis MH - Silicon Dioxide/chemistry MH - *Solid Phase Extraction/methods/instrumentation MH - Humans MH - Solanum tuberosum/chemistry OTO - NOTNLM OT - Dietary exposure OT - Food contaminants OT - Green analytical chemistry OT - Infant nutrition OT - Risk assessment OT - Sustainable sample preparation COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/11 23:35 MHDA- 2026/09/09 11:38 CRDT- 2026/08/11 18:07 PHST- 2026/04/01 00:00 [received] PHST- 2026/07/27 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/09/09 11:38 [medline] PHST- 2026/08/11 23:35 [pubmed] PHST- 2026/08/11 18:07 [entrez] AID - S0308-8146(26)02869-4 [pii] AID - 10.1016/j.foodchem.2026.150709 [doi] PST - ppublish SO - Food Chem. 2026 Oct 1;525(Pt 4):150709. doi: 10.1016/j.foodchem.2026.150709. Epub 2026 Aug 6. PMID- 42579997 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260821 IS - 1753-6405 (Electronic) IS - 1326-0200 (Linking) VI - 50 IP - 4 DP - 2026 Aug TI - Staff and student acceptability and feasibility of an evidence-based integrated physical activity and mental wellbeing program in Australian secondary schools: A pilot study. PG - 100580 LID - S1326-0200(26)00269-4 [pii] LID - 10.1016/j.anzjph.2026.100580 [doi] AB - OBJECTIVE: To determine the acceptability, feasibility, perceived effectiveness and factors influencing the implementation of an evidence-based integrated physical activity and mental wellbeing program in Australian secondary schools. METHODS: A pilot study of a teacher-delivered 5-week physical activity and mental wellbeing program for Year 7 students was conducted in two New South Wales (NSW) schools. Surveys and focus groups collected teacher- and/or student-data regarding fidelity of implementation, acceptability, feasibility, usefulness, confidence to deliver, enjoyment, perceived effectiveness and factors influencing implementation. RESULTS: Seven teachers and 87 students participated. Both schools implemented all program components. Teachers reported that the program components were acceptable (40%-100%), feasible (71%), that the resources were useful (86%-100%) and confidence in delivering all components (71%-100%). Students reported that the program information was acceptable (74%-78%) and enjoyable (48%-62%). Teachers and students perceived positive student health and wellbeing impacts (40%-83%). Key teacher-reported factors influencing implementation were sufficient financial resources (86%) and recognition for program implementation (71%). Students suggested increasing active lessons relative to theoretical lessons, peer and teacher participation and lesson activity autonomy to improve participation. CONCLUSIONS: The integrated physical activity and mental wellbeing program was acceptable and feasible, and important factors to improve implementation and student participation were identified. IMPLICATIONS FOR PUBLIC HEALTH: Findings support a controlled study to assess effects on student health and wellbeing outcomes. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Hodder, Rebecca K AU - Hodder RK AD - School of Medicine and Public Health, the University of Newcastle, Callaghan, NSW, Australia; Hunter New England Population Health, Wallsend, NSW, Australia. Electronic address: Rebecca.Hodder@health.nsw.gov.au. FAU - Wrigley, Jessica AU - Wrigley J AD - Hunter New England Population Health, Wallsend, NSW, Australia. FAU - Ainsworth, Emma AU - Ainsworth E AD - Hunter New England Population Health, Wallsend, NSW, Australia; Northern Territory Health, Allied Health Service, Katherine, NT, Australia. FAU - McDiarmid, Katrina AU - McDiarmid K AD - School of Medicine and Public Health, the University of Newcastle, Callaghan, NSW, Australia; Hunter New England Population Health, Wallsend, NSW, Australia. FAU - O'Brien, Kate M AU - O'Brien KM AD - School of Medicine and Public Health, the University of Newcastle, Callaghan, NSW, Australia; Hunter New England Population Health, Wallsend, NSW, Australia. FAU - Nathan, Nicole AU - Nathan N AD - School of Medicine and Public Health, the University of Newcastle, Callaghan, NSW, Australia; Hunter New England Population Health, Wallsend, NSW, Australia. FAU - Bartlem, Kate AU - Bartlem K AD - Hunter New England Population Health, Wallsend, NSW, Australia; School of Psychological Sciences, the University of Newcastle, Callaghan, NSW, Australia. FAU - Groombridge, Daniel AU - Groombridge D AD - Hunter New England Population Health, Wallsend, NSW, Australia. CN - Healthy Children's Initiative Secondary School Advisory Group AD - Hunter New England Population Health, Wallsend, NSW, Australia. FAU - Clinton-McHarg, Tara AU - Clinton-McHarg T AD - School of Medicine and Public Health, the University of Newcastle, Callaghan, NSW, Australia; Melbourne School of Population and Global Health, the University of Melbourne, Parkville, VIC, Australia. LA - eng PT - Journal Article DEP - 20260811 PL - United States TA - Aust N Z J Public Health JT - Australian and New Zealand journal of public health JID - 9611095 SB - IM MH - Humans MH - Pilot Projects MH - Female MH - *Mental Health MH - *Exercise/psychology MH - *Students/psychology MH - *Health Promotion/methods MH - Feasibility Studies MH - Schools MH - Male MH - Adolescent MH - Psychological Well-Being MH - New South Wales MH - *School Health Services/organization & administration MH - Program Evaluation MH - Focus Groups MH - Child MH - *School Teachers/psychology MH - Surveys and Questionnaires MH - Australia OTO - NOTNLM OT - adolescent OT - health promotion OT - mental wellbeing OT - physical activity OT - schools COIS- Conflicts of interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/11 23:35 MHDA- 2026/08/21 23:37 CRDT- 2026/08/11 18:05 PHST- 2024/12/03 00:00 [received] PHST- 2026/06/21 00:00 [revised] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/08/21 23:37 [medline] PHST- 2026/08/11 23:35 [pubmed] PHST- 2026/08/11 18:05 [entrez] AID - S1326-0200(26)00269-4 [pii] AID - 10.1016/j.anzjph.2026.100580 [doi] PST - ppublish SO - Aust N Z J Public Health. 2026 Aug;50(4):100580. doi: 10.1016/j.anzjph.2026.100580. Epub 2026 Aug 11. PMID- 42579937 OWN - NLM STAT- Publisher LR - 20260811 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 91 DP - 2026 Aug 11 TI - The mediating role of impulsivity in the relationship between multiple screen addiction and nighttime eating behaviors among adolescents. PG - 100-108 LID - S0882-5963(26)00372-6 [pii] LID - 10.1016/j.pedn.2026.08.003 [doi] AB - OBJECTIVE: This study examined whether impulsivity mediates the association between multiple screen addiction and nighttime eating behaviors among adolescents. METHODS: A cross-sectional design was used with 1247 adolescents recruited through purposive venue-based sampling with socioeconomic stratification in eastern Turkey province. Multiple screen addiction, impulsivity, and nighttime eating behaviors were assessed using validated self-report scales. A latent-variable structural equation model was tested, with age, gender, sleep duration, BMI z-score, and perceived socioeconomic status as covariates. Mediation was tested using bootstrap resampling (5000 resamples). RESULTS: Multiple screen addiction was positively associated with both impulsivity (beta = 0.272) and nighttime eating behaviors. Impulsivity partially mediated the association, accounting for approximately 28% of the total association, while the direct association between multiple screen addiction and nighttime eating behaviors remained the dominant pathway (approximately 72%). The structural model demonstrated acceptable fit (CFI = 0.924, RMSEA = 0.063, SRMR = 0.058). CONCLUSION: Impulsivity represents one partial mechanism linking multiple screen addiction to nighttime eating behaviors in adolescents. Pediatric and school health nurses may benefit from incorporating assessment of multiple screen addiction and self-regulation into routine adolescent care. Findings should be interpreted within the regional context of a single eastern Turkey province. IMPLICATIONS FOR NURSING PRACTICE: Interventions targeting adolescent health should adopt a multidimensional approach that includes screen time management, promotion of healthy eating habits, and strengthening self-regulation skills. Early identification of at-risk adolescents and development of school- and community-based nursing interventions may help prevent maladaptive behavioral patterns. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Evcimen, Hasan AU - Evcimen H AD - Mus Alparslan University, Department of Therapy and Rehabilitation Mus, Turkey. Electronic address: hsn_evcimen@hotmail.com. FAU - Bilgin, Sonay AU - Bilgin S AD - Ataturk University, Faculty of Nursing, Department of Public Health Nursing, Erzurum, Turkey. LA - eng PT - Journal Article DEP - 20260811 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM OTO - NOTNLM OT - Adolescent OT - Impulsivity OT - Multiple screen addiction OT - Nighttime eating OT - Structural equation modeling COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/11 23:35 MHDA- 2026/08/11 23:35 CRDT- 2026/08/11 18:01 PHST- 2026/04/14 00:00 [received] PHST- 2026/08/02 00:00 [revised] PHST- 2026/08/02 00:00 [accepted] PHST- 2026/08/11 23:35 [medline] PHST- 2026/08/11 23:35 [pubmed] PHST- 2026/08/11 18:01 [entrez] AID - S0882-5963(26)00372-6 [pii] AID - 10.1016/j.pedn.2026.08.003 [doi] PST - aheadofprint SO - J Pediatr Nurs. 2026 Aug 11;91:100-108. doi: 10.1016/j.pedn.2026.08.003. PMID- 42579708 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 8 DP - 2026 TI - A two-stage unified Bayesian framework for adolescent physical fitness surveillance in Sichuan, China: Latent factor measurement followed by spatiotemporal modeling. PG - e0355280 LID - 10.1371/journal.pone.0355280 [doi] LID - e0355280 AB - Large-scale adolescent fitness testing produces heterogeneous multi-item measurements. Translating these measurements into interpretable and comparable evidence for provincial surveillance remains challenging. We propose a two-stage Bayesian framework for adolescent physical fitness surveillance in Sichuan, China. In Stage 1, Bayesian confirmatory factor analysis maps cross-grade test items onto four latent fitness factors: strength, speed, endurance, and flexibility. This stage explicitly models item-level measurement error and item heterogeneity. In Stage 2, factor-level outcomes are modeled using Bayesian spatiotemporal hierarchical regression. This stage estimates covariate associations, temporal trends, and residual spatial heterogeneity. In the Sichuan application, the four latent factors showed clear and interpretable spatial structure. Residual spatial clustering persisted after adjustment for covariates, educational-stage effects, and shared temporal trends. Urbanization rate showed positive conditional associations with all four factors. Selected socioeconomic, geographic, and environmental covariates showed domain-specific associations, such as negative associations of GDP per capita and population density mainly with strength and speed. Model comparison using PSIS-LOO indicated that models with spatial random effects provided better conditional pointwise predictive fit than corresponding no-spatial models for all four factors, with satisfactory Pareto-k diagnostics. By separating latent measurement from regional spatiotemporal modeling, the proposed framework supports more interpretable regional comparisons. It also helps identify regions with persistent residual advantages or disadvantages, providing quantitative evidence for targeted monitoring and policy discussion. CI - Copyright: (c) 2026 Wei et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Wei, Honglei AU - Wei H AD - School of Mathematics, Southwest Jiaotong University, Chengdu, Sichuan, China. AD - Sichuan Province Big Data Research and Joint Application Technology Center of Student Health, Chengdu, Sichuan, China. FAU - Li, Haoran AU - Li H AD - School of Mathematics, Southwest Jiaotong University, Chengdu, Sichuan, China. AD - Sichuan Province Big Data Research and Joint Application Technology Center of Student Health, Chengdu, Sichuan, China. FAU - Pu, Maowu AU - Pu M AD - School of Mathematics, Southwest Jiaotong University, Chengdu, Sichuan, China. AD - Sichuan Province Big Data Research and Joint Application Technology Center of Student Health, Chengdu, Sichuan, China. FAU - He, Zhou AU - He Z AUID- ORCID: 0009-0003-5596-3445 AD - School of Mathematics, Southwest Jiaotong University, Chengdu, Sichuan, China. AD - Sichuan Province Big Data Research and Joint Application Technology Center of Student Health, Chengdu, Sichuan, China. FAU - Wang, Yiru AU - Wang Y AD - Sichuan Province Big Data Research and Joint Application Technology Center of Student Health, Chengdu, Sichuan, China. AD - College of International Education, Chengdu University of Technology (Oxford Brookes College), Chengdu, Sichuan, China. LA - eng PT - Journal Article DEP - 20260811 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Bayes Theorem MH - Humans MH - China MH - *Physical Fitness/physiology MH - Adolescent MH - Female MH - Male MH - Spatio-Temporal Analysis MH - Factor Analysis, Statistical PMC - PMC13460590 COIS- The authors have declared that no competing interests exist. EDAT- 2026/08/11 17:36 MHDA- 2026/08/11 17:37 PMCR- 2026/08/11 CRDT- 2026/08/11 13:43 PHST- 2026/01/19 00:00 [received] PHST- 2026/07/19 00:00 [accepted] PHST- 2026/08/11 17:37 [medline] PHST- 2026/08/11 17:36 [pubmed] PHST- 2026/08/11 13:43 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - PONE-D-26-03114 [pii] AID - 10.1371/journal.pone.0355280 [doi] PST - epublish SO - PLoS One. 2026 Aug 11;21(8):e0355280. doi: 10.1371/journal.pone.0355280. eCollection 2026. PMID- 42579393 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261007 IS - 1539-2570 (Electronic) IS - 0271-6798 (Linking) VI - 46 IP - 10 DP - 2026 Nov-Dec 01 TI - Is D-Dimer Associated With Disease Severity and Contralateral Slip Risk in Slipped Capital Femoral Epiphysis? PG - e1018-e1024 LID - 10.1097/BPO.0000000000003441 [doi] AB - BACKGROUND: To evaluate D-dimer levels in patients with slipped capital femoral epiphysis (SCFE), to investigate their association with disease severity and the development of contralateral slip, and to assess their contribution to existing predictive models. METHODS: In this single-center retrospective cohort study, 25 patients with unilateral SCFE diagnosed between January 2020 and April 2024 were included. The control group consisted of age- and sex-matched obese individuals and healthy subjects with normal body mass index (BMI). Clinical variables (age, sex, BMI, stability according to the Loder classification, and chronicity); laboratory parameters [complete blood count, neutrophil-to-lymphocyte ratio (NLR), inflammatory markers including C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR), and coagulation parameters including prothrombin time (PT), activated partial thromboplastin time (aPTT), fibrinogen, and D-dimer]; and radiographic measurements [Southwick angle, interhip angle difference, posterior sloping angle (PSA), and modified Oxford bone score (MOBS)] were analyzed. Subgroup analyses based on stability and chronicity were performed, and correlations between D-dimer levels and clinical, laboratory, and radiographic parameters were assessed. Multivariable logistic regression models were constructed to predict contralateral slip, and model performance was evaluated using receiver operating characteristic (ROC) curve analysis. RESULTS: D-dimer levels were significantly higher in the SCFE group compared with both obese and healthy control groups ( P <0.001). D-dimer showed positive correlations with CRP and NLR and negative correlations with the MOBS and the interhip Southwick angle difference. Higher D-dimer levels were observed in unstable and acute-on-chronic cases ( P <0.001). During a mean follow-up of 24 months, patients who developed contralateral slip had significantly higher D-dimer levels ( P =0.002). The addition of Southwick angle difference to a baseline model including age and MOBS increased the AUC from 0.73 to 0.80, while further inclusion of D-dimer improved the AUC to 0.87. However, the increase in AUC after addition of D-dimer was not statistically significant according to the paired DeLong test ( P =0.18). CONCLUSION: D-dimer levels are associated with disease severity and the risk of contralateral slip in SCFE. Incorporation of D-dimer into established clinical and radiographic parameters improved predictive model performance. These findings support the role of inflammatory and microvascular processes in the pathogenesis of SCFE and suggest that D-dimer may serve as a useful adjunct biomarker for risk stratification. LEVELS OF EVIDENCE: Level III-retrospective cohort study. CI - Copyright (c) 2026 Wolters Kluwer Health, LLC. All rights reserved. FAU - Kurk, Muhammed B AU - Kurk MB AD - Department of Orthopaedics and Traumatology, Medical Park Maltepe Hospital. FAU - Albayrak, Kutalmis AU - Albayrak K AUID- ORCID: 0000-0002-8427-8856 AD - Department of Orthopaedics and Traumatology, University of Health Sciences Baltalimani Bone Diseases Training and Research Hospital. FAU - Aydin, Abdurrahman AU - Aydin A AUID- ORCID: 0000-0002-5570-9493 AD - Department of Orthopedics and Traumatology, Duzce Cagsu Hospital, Duzce, Turkey. FAU - Kayis, Gorkem AU - Kayis G AUID- ORCID: 0000-0002-8562-217 AD - Department of Orthopaedics and Traumatology, University of Health Sciences Baltalimani Bone Diseases Training and Research Hospital. FAU - Akpinar, Evren AU - Akpinar E AUID- ORCID: 0000-0002-0702-289 AD - Department of Orthopedics and Traumatology, Memorial Goztepe Hospital, Istanbul. AD - Department of Orthopaedics and Traumatology, ISTUN Istanbul Health and Technology University, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20260811 PL - United States TA - J Pediatr Orthop JT - Journal of pediatric orthopedics JID - 8109053 RN - 0 (Fibrin Fibrinogen Degradation Products) RN - 0 (fibrin fragment D) RN - 0 (Biomarkers) RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Humans MH - *Fibrin Fibrinogen Degradation Products/analysis/metabolism MH - *Slipped Capital Femoral Epiphyses/blood MH - Retrospective Studies MH - Female MH - Male MH - Severity of Illness Index MH - Biomarkers/blood MH - Child MH - Adolescent MH - Risk Factors MH - C-Reactive Protein OTO - NOTNLM OT - D-dimer OT - coagulation OT - contralateral slip OT - inflammation OT - risk prediction OT - slipped capital femoral epiphysis COIS- The authors declare no conflicts of interest. EDAT- 2026/08/11 17:36 MHDA- 2026/10/07 17:33 CRDT- 2026/08/11 12:13 PHST- 2026/04/24 00:00 [received] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/10/07 17:33 [medline] PHST- 2026/08/11 17:36 [pubmed] PHST- 2026/08/11 12:13 [entrez] AID - 01241398-990000000-01274 [pii] AID - 10.1097/BPO.0000000000003441 [doi] PST - ppublish SO - J Pediatr Orthop. 2026 Nov-Dec 01;46(10):e1018-e1024. doi: 10.1097/BPO.0000000000003441. Epub 2026 Aug 11. PMID- 42579372 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260817 IS - 1540-8175 (Electronic) IS - 0742-2822 (Print) IS - 0742-2822 (Linking) VI - 43 IP - 8 DP - 2026 Aug TI - Pretreatment Coronary Ultrasound Radiomics Combined With the Prognostic Nutritional Index for Predicting IVIG Resistance in Children With Kawasaki Disease. PG - e70559 LID - 10.1111/echo.70559 [doi] LID - e70559 AB - BACKGROUND: Intravenous immunoglobulin (IVIG) resistance in children with Kawasaki disease (KD) is associated with an increased risk of coronary artery injury and subsequent adverse cardiovascular outcomes. Early identification of patients at risk remains difficult in clinical practice. Conventional coronary ultrasound is largely based on geometric parameters, such as luminal diameter and Z scores, and may not fully capture local heterogeneity within coronary images. In this study, we investigated whether pretreatment coronary artery ultrasound radiomics could improve early identification of IVIG resistance in children with KD. We further developed a multimodal prediction model incorporating radiomics, the prognostic nutritional index (PNI), and clinical characteristics. METHODS: A total of 352 children diagnosed with KD and treated at The First Affiliated Hospital of Guangxi Medical University between January 2020 and January 2026 were retrospectively included. All patients received standardized treatment after diagnosis. Demographic characteristics, pretreatment laboratory results, conventional coronary ultrasound parameters, and two-dimensional static ultrasound images of the left coronary artery (LCA), left anterior descending artery (LAD), and right coronary artery (RCA) were collected. The pretreatment two-dimensional static coronary ultrasound images were imported into 3D Slicer for region-of-interest segmentation. A clinical prediction model was constructed using multivariable logistic regression. PNI was defined a priori as the primary nutritional-immunologic indicator. In addition, the potential incremental predictive value of other nutritional-inflammatory indices, including the C-reactive protein-to-albumin ratio (CAR), neutrophil-to-albumin ratio (NAR), neutrophil percentage-to-albumin ratio (NPAR), and C-reactive protein-albumin-lymphocyte (CALLY) index, was further evaluated. Radiomics features were selected through repeated segmentation, intraclass correlation coefficient (ICC)-based stability filtering, correlation filtering, and least absolute shrinkage and selection operator (LASSO) regression. The Clinic, Clinic + PNI, Radiomics, and Clinic + PNI + Radiomics models were assessed using receiver operating characteristic curves, DeLong tests, calibration curves, decision curve analysis, and Shapley Additive Explanations (SHAP) interpretation. The Kobayashi, Egami, and Sano scores were evaluated in the same training and validation cohorts. RESULTS: Among the 352 children, 57 (16.2%) were classified as IVIG resistant. Multivariable analysis showed that higher pretreatment maximum coronary artery Z score (Z(max)), longer fever duration, and higher neutrophil count were associated with an increased risk of IVIG resistance. In the validation cohort, the Clinic + PNI model showed favorable discriminatory ability, with an AUC of 0.855 (95% CI, 0.767-0.911), a sensitivity of 0.882, and a negative predictive value of 0.969. Seven radiomics features were selected and used to construct the radiomics score (Rad-score). In the training cohort, the Clinic + PNI + Radiomics model achieved higher AUC values than the Clinic, Clinic + PNI, and Radiomics models. This pattern was also observed in the validation cohort, where the integrated model achieved the highest AUC of 0.880 (95% CI, 0.817-0.944), although the between-model differences did not reach statistical significance. Decision curve analysis showed that the integrated model offered a favorable net benefit within clinically meaningful threshold ranges. SHAP analysis suggested that its predictions reflected the joint influence of systemic inflammatory burden, nutritional and immune status, and local imaging heterogeneity captured from coronary ultrasound images. The Kobayashi, Egami, and Sano scores yielded validation AUCs of 0.616, 0.567, and 0.449, respectively. CONCLUSIONS: Pretreatment coronary ultrasound radiomics may provide complementary information to conventional clinical, laboratory, and ultrasonographic parameters for assessing the risk of IVIG resistance in children with KD. By integrating inflammatory burden, nutritional-immunologic status, and local coronary imaging heterogeneity, the Clinic + PNI + Radiomics model showed favorable discrimination and potential clinical net benefit in internal validation. However, its incremental value and clinical applicability require further confirmation in external cohorts. CI - (c) 2026 Wiley Periodicals LLC. FAU - Xiao, Caiyi AU - Xiao C AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China. AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Chen, Chaorong AU - Chen C AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China. AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Huang, Yuanyuan AU - Huang Y AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China. AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Wei, Xianbin AU - Wei X AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Li, Bin AU - Li B AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Wu, Jing AU - Wu J AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Huang, Huiying AU - Huang H AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Su, Dunhui AU - Su D AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Zhang, Bulin AU - Zhang B AD - Department of Ultrasonic Medicine, Liuzhou People's Hospital, Liuzhou, China. FAU - Wu, Ji AU - Wu J AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Guangxi Medical University, Nanning, China. LA - eng PT - Journal Article PL - United States TA - Echocardiography JT - Echocardiography (Mount Kisco, N.Y.) JID - 8511187 RN - 0 (Immunoglobulins, Intravenous) SB - IM MH - Humans MH - *Mucocutaneous Lymph Node Syndrome/drug therapy MH - Male MH - Female MH - Radiomics MH - Retrospective Studies MH - Prognosis MH - Child, Preschool MH - *Drug Resistance MH - *Immunoglobulins, Intravenous/therapeutic use MH - *Coronary Vessels/diagnostic imaging MH - *Nutrition Assessment MH - *Echocardiography/methods MH - Ultrasonography/methods MH - Infant PMC - PMC13460361 OTO - NOTNLM OT - IVIG resistance OT - Kawasaki disease OT - coronary artery ultrasound OT - prediction model OT - prognostic nutritional index OT - radiomics COIS- The authors declare no conflicts of interest. EDAT- 2026/08/11 17:36 MHDA- 2026/08/11 17:37 PMCR- 2026/08/11 CRDT- 2026/08/11 12:04 PHST- 2026/07/01 00:00 [revised] PHST- 2026/05/05 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/08/11 17:37 [medline] PHST- 2026/08/11 17:36 [pubmed] PHST- 2026/08/11 12:04 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - ECHO70559 [pii] AID - 10.1111/echo.70559 [doi] PST - ppublish SO - Echocardiography. 2026 Aug;43(8):e70559. doi: 10.1111/echo.70559. PMID- 42579007 OWN - NLM STAT- Publisher LR - 20260811 IS - 2366-0058 (Electronic) DP - 2026 Aug 11 TI - A simplified MRI‑based risk score and nomogram to predict initial objective response in unresectable hepatocellular carcinoma treated with HAIC, targeted therapy, and immunotherapy: a multicenter study. LID - 10.1007/s00261-026-05732-6 [doi] AB - PURPOSE: This study aimed to develop and validate a simplified risk score based on pretreatment Gd‑EOB‑DTPA MRI features for the noninvasive prediction of initial objective response rate (ORR) in patients with unresectable hepatocellular carcinoma (uHCC) undergoing triple therapy (hepatic arterial infusion chemotherapy [HAIC], tyrosine kinase inhibitors, and immune checkpoint inhibitors). METHODS: This retrospective study enrolled 223 uHCC patients from two medical centers who underwent Gd‑EOB‑DTPA‑enhanced MRI prior to initiating triple therapy (training set: n = 127; external test set: n = 96). Imaging features were evaluated and extracted. Independent predictors of initial ORR were identified by multivariate logistic regression to build a simplified imaging risk score (I-score), and a nomogram was constructed to visualize the final predictive model. Model performance was assessed by AUC, calibration (Hosmer‑Lemeshow test), confusion matrix, and decision curve analysis (DCA), with internal bootstrap and external validation. SHAP analysis provided interpretability. Patients were stratified into low‑ and high‑risk groups, and Kaplan‑Meier curves for progression‑free survival (PFS) and overall survival (OS) were compared. RESULTS: Three MRI features (irregular morphology, rim enhancement, peritumoral low signal) were independent negative predictors of initial ORR. The simplified I-score was formulated as: 1x(irregular morphology) + 1 x (rim enhancement) + 2 x (peritumoral low signal), with an optimal cut-off of 1.5. Following LASSO regression, BMI > 22.55, PA < 182.5 mg/L, NLR > 2.37, and I-score >/= 2 were included in the nomogram. The nomogram achieved AUCs of 0.890 in training and 0.841 in validation for ORR prediction, demonstrating good calibration (P > 0.05) and clinical benefit. SHAP analysis identified I-score as the most important contributor. The model significantly outperformed BCLC, ALBI, Child‑Pugh, and Six‑and‑Twelve staging systems (all P < 0.05). High‑risk patients had significantly worse PFS and OS than low‑risk patients. CONCLUSION: The MRI‑based simplified risk score and the derived nomogram offer a noninvasive and precise method for predicting initial ORR and classifying prognosis in uHCC patients undergoing triple therapy. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Wang, Yi-Kang AU - Wang YK AD - Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Feng, Hua-Guo AU - Feng HG AD - Chongqing Red Cross Hospital, Chongqing, China. FAU - Liu, Yan-Han AU - Liu YH AD - Chongqing University Jiangjin Hospital, Chongqing, China. FAU - Zhang, Chun-Yu AU - Zhang CY AD - Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Zhou, Xue AU - Zhou X AD - Chongqing University Jiangjin Hospital, Chongqing, China. FAU - Liu, Hai-Ling AU - Liu HL AD - Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. 980956941@qq.com. FAU - Liu, Zuo-Jin AU - Liu ZJ AD - Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. 300376@hospital.cqmu.edu.cn. FAU - Tan, Hao-Yang AU - Tan HY AUID- ORCID: 0000-0001-5739-378X AD - Chongqing University Jiangjin Hospital, Chongqing, China. 13609454209@163.com. LA - eng GR - 82504160/National Natural Science Foundation of China/ GR - 82370672/National Natural Science Foundation of China/ GR - BX20250259/China Postdoctoral Science Foundation/ GR - 2025YCXM010/Chongqing University Jiangjin Hospital Internal Cultivation Project/ PT - Journal Article DEP - 20260811 PL - United States TA - Abdom Radiol (NY) JT - Abdominal radiology (New York) JID - 101674571 SB - IM OTO - NOTNLM OT - Hepatic arterial infusion chemotherapy OT - Hepatocellular carcinoma OT - Imaging scores OT - Initial objective response OT - Magnetic resonance imaging COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/08/11 12:37 MHDA- 2026/08/11 12:37 CRDT- 2026/08/11 11:05 PHST- 2026/01/07 00:00 [received] PHST- 2026/08/02 00:00 [accepted] PHST- 2026/08/11 12:37 [medline] PHST- 2026/08/11 12:37 [pubmed] PHST- 2026/08/11 11:05 [entrez] AID - 10.1007/s00261-026-05732-6 [pii] AID - 10.1007/s00261-026-05732-6 [doi] PST - aheadofprint SO - Abdom Radiol (NY). 2026 Aug 11. doi: 10.1007/s00261-026-05732-6. PMID- 42578774 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260811 IS - 2724-7031 (Electronic) IS - 0041-4131 (Linking) VI - 104 IP - 4 DP - 2026 May 1 TI - Chronic pain among patients treated for breast cancer: Prevalence and associates factors. PG - 678-682 LID - 10.62438/tunismed.v104i05.6520 [doi] AB - OBJECTIVES: Chronic pain has emerged as a significant health issue among women treated for breast cancer, representing a substantial burden that negatively affects quality of life. This study aimed to determine the prevalence and characteristics of chronic pain among Tunisian breast cancer survivors. METHODS: We conducted a cross-sectional descriptive and analytical study including 100 Tunisian women treated for breast cancer at the Medical Oncology Department of Fattouma Bourguiba University Hospital (Monastir, Tunisia). Data collected included sociodemographic and clinical characteristics, lifestyle habits, and medical history. Validated instruments were used, including the Brief Pain Inventory (BPI), Pain Catastrophizing Scale (PCS), DN4 questionnaire, Hospital Anxiety and Depression Scale (HADS), and Family APGAR score. RESULTS: The prevalence of chronic pain in our population was 100%. All participants reported persistent pain following breast cancer surgery, without any other identified medical cause. The most common pain locations were the breast and ipsilateral upper limb. Pain interference was generally mild in both affective and activity domains. Most participants (88%) belonged to highly functional families. Higher pain intensity was significantly associated with a greater number of children and a history of dysthyroidism. Multivariate analysis identified body mass index, number of children, and number of lymph nodes removed as independent predictors of pain intensity. Higher pain intensity was also associated with increased anxiety levels. CONCLUSIONS: Chronic pain is highly prevalent among breast cancer survivors and is influenced by multiple factors, highlighting the need for comprehensive assessment and management strategies. FAU - Khechine, Wiem AU - Khechine W AD - Department of Medical Oncology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. FAU - Chouat, Marwa AU - Chouat M AD - Department of Medical Oncology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. FAU - Hmad, Alaeddine AU - Hmad A AD - Department of Medical Oncology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. FAU - Amamou, Badii AU - Amamou B AD - Department of Psychiatry, Fattouma Bourguiba University Hospital, Monastir, Tunisia. FAU - Felfoul, Asma AU - Felfoul A AD - Department of Medical Oncology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. FAU - Korbi, Asma AU - Korbi A AD - Department of Gynecology and Obstetrics, Maternity and neonatology center, Monastir, Tunisia. FAU - Jebali, Fethi AU - Jebali F AD - Department of Anesthesiology, Maternity and neonatology center, Monastir, Tunisia. FAU - Zaied, Sonia AU - Zaied S AD - Department of Medical Oncology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. FAU - Daldoul, Amira AU - Daldoul A AD - Department of Medical Oncology, Fattouma Bourguiba University Hospital, Monastir, Tunisia. LA - eng PT - Journal Article DEP - 20260501 PL - Tunisia TA - Tunis Med JT - La Tunisie medicale JID - 0413766 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - *Breast Neoplasms/complications/epidemiology/therapy/surgery MH - Prevalence MH - *Chronic Pain/epidemiology/etiology MH - Tunisia/epidemiology MH - Middle Aged MH - Adult MH - Quality of Life MH - Aged MH - Pain Measurement MH - Mastectomy/adverse effects MH - Cancer Survivors/statistics & numerical data MH - Surveys and Questionnaires MH - Risk Factors OTO - NOTNLM OT - Breast cancer survivors OT - Breast conserving surgery OT - Chronic pain OT - Mastectomy OT - Quality of life EDAT- 2026/08/11 12:37 MHDA- 2026/08/11 12:38 CRDT- 2026/08/11 09:52 PHST- 2025/10/12 00:00 [received] PHST- 2026/04/12 00:00 [accepted] PHST- 2026/08/11 12:38 [medline] PHST- 2026/08/11 12:37 [pubmed] PHST- 2026/08/11 09:52 [entrez] AID - /article/view/6520 [pii] AID - 10.62438/tunismed.v104i05.6520 [doi] PST - epublish SO - Tunis Med. 2026 May 1;104(4):678-682. doi: 10.62438/tunismed.v104i05.6520. PMID- 42578713 OWN - NLM STAT- Publisher LR - 20260811 IS - 1668-3501 (Electronic) IS - 0325-0075 (Linking) DP - 2026 Aug 13 TI - Differences in psychomotor development among preschool children according to the type of early childhood education institution in Temuco, Chile. PG - e202510950 LID - 10.5546/aap.2025-10950.eng [doi] AB - Introduction. Psychomotor development is an essential indicator of child growth that integrates cognitive, motor, linguistic, and socio-emotional dimensions. Objective. To evaluate the association between the type of educational institution and psychomotor development in preschoolers. Population and methods. A cross-sectional analytical study was conducted in 2019 among children aged 2 to 4 years attending public and private preschools. Psychomotor development was assessed using the Test of Child Learning and Development (TADI, by its Spanish acronym), validated in Chile. Multinomial logistic regression was performed, adjusting for socioeconomic status, maternal education, and the child's age, sex, and nutritional status. Results. A total of 151 children were included; 52.7% of the participants were girls, and the mean age was 40 +/- 8.1 months. An association was observed between attending public facilities and a classification of risk or delay in global psychomotor development (OR = 7.34; 95%CI: 1.65-32.58; p <0.05) and cognitive development (OR = 10.83; 95%CI: 1.64-71.59; p <0.05), compared with private facilities. Male gender was associated with increased risk of, or delay in, global psychomotor development (OR = 6.53; 95%CI: 1.94-22.08), cognitive development (OR = 4.45; 95%CI: 1.41-13.99), and motor development (OR = 3.07; 95%CI: 1.17-8.08). Conclusion. The type of educational setting and gender were associated with differences in psychomotor development among preschoolers. The findings should be interpreted with consideration of possible sociodemographic and contextual factors that were not fully captured. CI - Sociedad Argentina de Pediatria. FAU - Lavados-Romo, Pamela AU - Lavados-Romo P AUID- ORCID: 0000-0002-6799-798X AD - Department of Preclinical Sciences, School of Medicine, Universidad de La Frontera, Temuco, Chile. AD - Center for Research in Cardiometabolic and Nutritional Epidemiology (EPICYN, by its Spanish acronym), School of Medicine, Universidad de La Frontera, Temuco, Chile. FAU - Andrade-Mayorga, Omar AU - Andrade-Mayorga O AD - Department of Preclinical Sciences, School of Medicine, Universidad de La Frontera, Temuco, Chile. AD - Center for Research in Cardiometabolic and Nutritional Epidemiology (EPICYN, by its Spanish acronym), School of Medicine, Universidad de La Frontera, Temuco, Chile. FAU - Luza, Nelly AU - Luza N AD - Department of Preclinical Sciences, School of Medicine, Universidad de La Frontera, Temuco, Chile. FAU - Toloza-Torres, Leonardo AU - Toloza-Torres L AD - Department of Rehabilitation Sciences, School of Medicine, Universidad de La Frontera, Temuco, Chile. FAU - Bahamondes, Ornella AU - Bahamondes O AD - Department of Rehabilitation Sciences, School of Medicine, Universidad de La Frontera, Temuco, Chile. FAU - Mella, Camila AU - Mella C AD - Department of Physical Education, Sports, and Recreation, School of Medicine, Universidad de La Frontera, Temuco, Chile. FAU - Espejo Mandujano, Valentina AU - Espejo Mandujano V AD - Pediatrics, Universidad de La Frontera, Dr. Hernan Henriquez Aravena Hospital, Temuco, Chile. FAU - Vasquez, Paulina AU - Vasquez P AD - Department of Diagnostic Processes and Evaluation, School of Health Sciences, Universidad Catolica de Temuco, Chile. FAU - Lubini Fuica, Giancarlo AU - Lubini Fuica G AD - Medical Program, School of Medicine, Universidad de La Frontera, Temuco, Chile. FAU - Pinto-Morales, Francisca AU - Pinto-Morales F AD - Trovolhue Family Health Center, Municipal Health Department, Carahue, Chile. FAU - Balboa-Castillo, Teresa AU - Balboa-Castillo T AD - Center for Research in Cardiometabolic and Nutritional Epidemiology (EPICYN, by its Spanish acronym), School of Medicine, Universidad de La Frontera, Temuco, Chile. AD - Department of Public Health, School of Medicine, Universidad de La Frontera, Temuco, Chile. LA - eng LA - spa PT - Journal Article TT - Diferencias en el desarrollo psicomotor infantil en preescolares segun el tipo de establecimiento de educacion inicial en Temuco, Chile. DEP - 20260813 PL - Argentina TA - Arch Argent Pediatr JT - Archivos argentinos de pediatria JID - 0372460 SB - IM OTO - NOTNLM OT - growth and development OT - neurodevelopment OT - preschool education OT - private sector OT - public sector EDAT- 2026/08/11 12:37 MHDA- 2026/08/11 12:37 CRDT- 2026/08/11 09:20 PHST- 2026/08/11 12:37 [medline] PHST- 2026/08/11 12:37 [pubmed] PHST- 2026/08/11 09:20 [entrez] AID - 10.5546/aap.2025-10950.eng [doi] PST - aheadofprint SO - Arch Argent Pediatr. 2026 Aug 13:e202510950. doi: 10.5546/aap.2025-10950.eng. PMID- 42578573 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260813 IS - 1460-2210 (Electronic) IS - 0141-5387 (Print) IS - 0141-5387 (Linking) VI - 48 IP - 5 DP - 2026 Aug 6 TI - Automated prediction of hand-wrist maturation stage from lateral cephalometric and panoramic radiographs using a deep learning approach. LID - 10.1093/ejo/cjag054 [doi] LID - cjag054 AB - OBJECTIVES: This study aimed to predict hand-wrist developmental stages, the most reliable indicator of skeletal maturation, from panoramic radiographs (PRs) and lateral cephalometric radiographs (LCRs) using deep learning and to compare the two methods. The goal was to provide a rapid and objective method for growth assessment in orthodontic planning without additional radiation exposure. METHODS: A total of 3703 patients who underwent hand-wrist radiographs (HWRs), PRs, and LCRs prior to orthodontic treatment were retrospectively analyzed. HWRs were classified according to Bjork's 9-stage system and reduced to 5- and 3-group schemes. YOLOv5 was used for automated reference point detection, and the extracted regions were classified using a multimodal deep learning framework. EfficientNet-B0 was used for 9-stage classification, and EfficientNet-B4 was used for 5- and 3-group classifications. Clinical variables (age, gender) were included, and hybrid loss strategies addressed class imbalance while preserving sequential stage relationships. Performance metrics included accuracy, recall, mAP@0.5, balanced accuracy, Cohen's Kappa coefficient, and detailed error analysis; 5-fold cross-validation and ensemble learning were used to improve robustness. RESULTS: YOLOv5 detected tooth roots in PRs (accuracy 92.5%, recall 93.3%, mAP@0.5 = 0.942) and cervical vertebrae in LCRs (accuracy 98.9%, recall 99.9%, mAP@0.5 = 0.995). In PRs, the standard accuracy in 9-, 5-, and 3-stage classifications was 0.3648, 0.5307, and 0.7520, respectively, while in LCRs, the standard accuracy in 9-, 5-, and 3-stage classifications was 0.4350, 0.6336, and 0.8975, respectively. CONCLUSION: Deep learning can reliably automate skeletal maturation assessment across imaging methods and resolutions. Appropriately optimized models provide valuable decision support in orthodontic treatment, increasing efficiency and consistency. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the European Orthodontic Society. FAU - Edik, Merve AU - Edik M AUID- ORCID: 0009-0002-9801-5392 AD - Department of Oral and Maxillofacial Radiology, Erciyes University Faculty of Dentistry, Kosk Mah. Ahmet El Biruni Cad. No: 52, Melikgazi, Kayseri 38030, Turkey. FAU - Celebi, Fatma AU - Celebi F AUID- ORCID: 0000-0001-7472-8297 AD - Department of Software Engineering, Faculty of Engineering, Erciyes University, Kosk Mah. Ahmet El Biruni Cad. No: 52, Melikgazi, Kayseri 38030, Turkey. FAU - Etoz, Meryem AU - Etoz M AUID- ORCID: 0000-0001-7222-0430 AD - Department of Oral and Maxillofacial Radiology, Erciyes University Faculty of Dentistry, Kosk Mah. Ahmet El Biruni Cad. No: 52, Melikgazi, Kayseri 38030, Turkey. LA - eng GR - Scientific and Technological Research Council of Turkey/ PT - Comparative Study PT - Journal Article PL - England TA - Eur J Orthod JT - European journal of orthodontics JID - 7909010 SB - IM MH - Humans MH - *Deep Learning MH - *Radiography, Panoramic/methods MH - *Cephalometry/methods MH - Female MH - Retrospective Studies MH - Male MH - *Age Determination by Skeleton/methods MH - Adolescent MH - Child MH - Convolutional Neural Networks MH - Anatomic Landmarks/diagnostic imaging MH - Detection Algorithms MH - *Hand Bones/growth & development/diagnostic imaging PMC - PMC13458939 OTO - NOTNLM OT - EfficientNet OT - deep learning OT - hand-wrist maturation OT - lateral cephalometric radiography OT - panoramic radiography COIS- Conflicts of interest: The authors declare that they have no conflicts of interest. EDAT- 2026/08/11 12:37 MHDA- 2026/08/11 12:38 PMCR- 2026/08/11 CRDT- 2026/08/11 08:23 PHST- 2026/08/11 12:38 [medline] PHST- 2026/08/11 12:37 [pubmed] PHST- 2026/08/11 08:23 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - 8758821 [pii] AID - cjag054 [pii] AID - 10.1093/ejo/cjag054 [doi] PST - ppublish SO - Eur J Orthod. 2026 Aug 6;48(5):cjag054. doi: 10.1093/ejo/cjag054. PMID- 42577908 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260811 LR - 20260813 IS - 1178-6973 (Print) IS - 1178-6973 (Electronic) IS - 1178-6973 (Linking) VI - 19 DP - 2026 TI - Miliary Tuberculosis: A Comprehensive Review of Epidemiology, Clinical Manifestations, Diagnosis, Treatment, and Complications. PG - 616761 LID - 10.2147/IDR.S616761 [doi] LID - 616761 AB - Miliary tuberculosis (TB) represents a potentially fatal form of disseminated TB resulting from the lymphohematogenous dissemination of Mycobacterium tuberculosis. Although accounting for approximately 1-2% of all TB cases in immunocompetent adults, its mortality rate exceeds 30%. This review screened peer-reviewed, original research studies via four databases (PubMed, EMBASE, MEDLINE, and CENTRAL) to synthesize up-to-date evidence. Key risk factors include human immunodeficiency virus (HIV) co-infection, anti-tumor necrosis factor-alpha (TNF-alpha) agents and chronic malnutrition. The clinical presentation of miliary TB is notoriously nonspecific, with fever, night sweats, weight loss, and constitutional symptoms predominating. Over 60% of patients have extrapulmonary complications, with central nervous system (CNS) involvement in 10-30%, abdominal involvement in 15-30%, and skeletal involvement in up to 17%. Laboratory abnormalities are common, including elevated erythrocyte sedimentation rate (ESR), anemia, lymphopenia, and nearly universal C-reactive protein (CRP) elevation. Diagnoses remain difficult due to paucibacillary lesions; novel molecular assays and a validated CNS prediction scoring system greatly improve diagnostic efficiency, while multiple microbiological and invasive tissue sampling modalities are briefly summarized for comprehensive clinical reference. Standard 6-month isoniazid, rifampicin, pyrazinamide ethambutol and isoniazid, rifampicin (HRZE-HR) regimens apply to isolated pulmonary miliary TB, whereas 9-12-month extended therapy plus adjunctive dexamethasone is required for CNS complications. Drug resistant cases demand 18-24-month individualized regimens with high blood-brain barrier penetration. Severe complications including tuberculous meningitis and high mortality acute respiratory distress syndrome (ARDS) are fully discussed, and TNF-alpha antagonists act as salvage therapy for steroid-refractory tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS). Bacillus Calmette-Guerin (BCG) vaccination provides substantial protection against miliary TB in children, with efficacy of approximately 77% and favorable cost-effectiveness. Existing reviews lack integrated post-pandemic epidemiological data, cutting-edge molecular diagnostics and modern extrapulmonary treatment algorithms; this paper fills such gaps to offer balanced clinical guidance for frontline clinicians. CI - (c) 2026 Qiu et al. FAU - Qiu, Yukun AU - Qiu Y AUID- ORCID: 0009-0008-3685-2746 AD - Department of Emergency Medicine, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, Gansu, People's Republic of China. FAU - Tang, Yubin AU - Tang Y AD - Department of Emergency Medicine, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, Gansu, People's Republic of China. FAU - Yu, Shuqing AU - Yu S AD - Lanzhou Pulmonary Hospital, Lanzhou, Gansu, People's Republic of China. FAU - He, Jiaoyu AU - He J AD - Lanzhou Pulmonary Hospital, Lanzhou, Gansu, People's Republic of China. FAU - Wang, Xiaohui AU - Wang X AUID- ORCID: 0000-0002-1934-1011 AD - Clinical Laboratory, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, Gansu, China. FAU - Liang, Juan AU - Liang J AD - Department of Emergency Medicine, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, Gansu, People's Republic of China. FAU - Li, Yamei AU - Li Y AD - Department of Emergency Medicine, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, Gansu, People's Republic of China. FAU - Sun, Mei AU - Sun M AD - Department of Emergency Medicine, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, Gansu, People's Republic of China. FAU - Xiao, Yongjiu AU - Xiao Y AUID- ORCID: 0000-0001-9140-3945 AD - Department of Emergency Medicine, The 940th Hospital of Joint Logistics Support Force of PLA, Lanzhou, Gansu, People's Republic of China. LA - eng PT - Journal Article PT - Review DEP - 20260806 PL - New Zealand TA - Infect Drug Resist JT - Infection and drug resistance JID - 101550216 PMC - PMC13455802 OTO - NOTNLM OT - complications OT - diagnosis OT - miliary tuberculosis OT - prognosis OT - treatment COIS- The authors declare that they have no competing interests. EDAT- 2026/08/11 12:37 MHDA- 2026/08/11 12:38 PMCR- 2026/08/06 CRDT- 2026/08/11 06:38 PHST- 2026/04/14 00:00 [received] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/08/11 12:38 [medline] PHST- 2026/08/11 12:37 [pubmed] PHST- 2026/08/11 06:38 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 616761 [pii] AID - 10.2147/IDR.S616761 [doi] PST - epublish SO - Infect Drug Resist. 2026 Aug 6;19:616761. doi: 10.2147/IDR.S616761. eCollection 2026. PMID- 42577488 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260811 LR - 20260923 IS - 1664-302X (Print) IS - 1664-302X (Electronic) IS - 1664-302X (Linking) VI - 17 DP - 2026 TI - Integrated multiomics reveals stable microbe-metabolite relationships in pediatric celiac disease. PG - 1866060 LID - 10.3389/fmicb.2026.1866060 [doi] LID - 1866060 AB - Celiac disease is a lifelong immune-mediated disease triggered by dietary gluten and managed exclusively through a strict gluten-free diet. Differences in the gut microbiome are consistently observed in celiac disease, yet the associated metabolic consequences remain insufficiently defined. This study evaluated the stool microbiome-metabolome relationship in children from Canterbury, New Zealand, a region with a notably high prevalence of celiac disease ( approximately 1 in 82). Eleven children with untreated celiac disease and 10 controls were assessed, with nine children resampled after 6 months of gluten-free diet adherence. Stool samples were subjected to 16S rRNA sequencing, targeted and untargeted metabolomic profiling, and multi-omics integration using cross-block and machine-learning approaches. Celiac disease was characterized by consistent reproducible changes in a small set of resampled-stable taxa and metabolites, rather than a uniform shift. The most prominent finding was rearrangement within Bacteroides rather than a uniform shift: B. ovatus increased reproducibly in both untreated and treated disease, while integration analyses associated B. fragilis with celiac disease and B. vulgatus with controls. Metabolite changes were observed in two linked axes: a butyrate-led fermentation signature and a redox and organic acid signature, both elevated in untreated disease and shifting toward control levels after 6 months of gluten-free diet. Recovery was partial, and the diet imposed its own signature, notably an increase in the fat-responsive pathobiont Bilophila wadsworthia. Machine learning discrimination was modest (ROC-AUC = 0.66-0.68, PR-AUC = 0.73-0.79), but the microbiome and metabolome aligned along one reproducible cross-omic axis. The results support prioritizing a concise list of reproducible candidate features for mechanistic validation and longitudinal treatment monitoring in more extensive cohorts, rather than for immediate diagnostic application. CI - Copyright (c) 2026 Prendergast, Aitchison, Ho, Morris, Gobl, Dobson, Day and Ogilvie. FAU - Prendergast, Peter J AU - Prendergast PJ AD - School of Biological Sciences, University of Canterbury, Christchurch, New Zealand. AD - Biomolecular Interaction Centre, University of Canterbury, Christchurch, New Zealand. AD - Riddet Institute, University of Canterbury, Christchurch, New Zealand. FAU - Aitchison, Alan AU - Aitchison A AD - Department of Paediatrics and Child Health, The University of Otago Christchurch, New Zealand. FAU - Ho, Shaun S C AU - Ho SSC AD - Department of Gastroenterology and Clinical Nutrition, The Royal Children's Hospital, Melbourne, Parkville, VIC, Australia. AD - Murdoch Children's Research Institute, Parkville, VIC, Australia. AD - Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia. FAU - Morris, Vanessa K AU - Morris VK AD - School of Biological Sciences, University of Canterbury, Christchurch, New Zealand. AD - Biomolecular Interaction Centre, University of Canterbury, Christchurch, New Zealand. FAU - Gobl, Christoph AU - Gobl C AD - School of Biological Sciences, University of Canterbury, Christchurch, New Zealand. AD - Biomolecular Interaction Centre, University of Canterbury, Christchurch, New Zealand. AD - Matai Haora - Centre for Redox Biology and Medicine, The University of Otago Christchurch, New Zealand. FAU - Dobson, Renwick C J AU - Dobson RCJ AD - School of Biological Sciences, University of Canterbury, Christchurch, New Zealand. AD - Biomolecular Interaction Centre, University of Canterbury, Christchurch, New Zealand. AD - Riddet Institute, University of Canterbury, Christchurch, New Zealand. AD - Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Parkville, VIC, Australia. FAU - Day, Andrew S AU - Day AS AD - Department of Paediatrics and Child Health, The University of Otago Christchurch, New Zealand. FAU - Ogilvie, Olivia J AU - Ogilvie OJ AD - School of Biological Sciences, University of Canterbury, Christchurch, New Zealand. AD - Biomolecular Interaction Centre, University of Canterbury, Christchurch, New Zealand. AD - Riddet Institute, University of Canterbury, Christchurch, New Zealand. LA - eng PT - Journal Article DEP - 20260727 PL - Switzerland TA - Front Microbiol JT - Frontiers in microbiology JID - 101548977 PMC - PMC13454391 OTO - NOTNLM OT - Bacteroides OT - Bilophila OT - celiac disease OT - gluten-free diet OT - gut microbiome OT - metabolomics OT - multiomics OT - short-chain fatty acids COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author AD declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/08/11 12:37 MHDA- 2026/08/11 12:38 PMCR- 2026/07/27 CRDT- 2026/08/11 06:06 PHST- 2026/04/27 00:00 [received] PHST- 2026/06/20 00:00 [revised] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/08/11 12:38 [medline] PHST- 2026/08/11 12:37 [pubmed] PHST- 2026/08/11 06:06 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 10.3389/fmicb.2026.1866060 [doi] PST - epublish SO - Front Microbiol. 2026 Jul 27;17:1866060. doi: 10.3389/fmicb.2026.1866060. eCollection 2026. PMID- 42577167 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Latent profiles of problematic internet use and their associations with physical activity levels among college students: a cross-sectional study. PG - 1818418 LID - 10.3389/fpubh.2026.1818418 [doi] LID - 1818418 AB - OBJECTIVE: To identify latent profiles of problematic internet use (PIU) among college students and examine their associations with physical activity (PA) levels. METHODS: A stratified cluster sampling survey was conducted among 2,660 college students from central China. Problematic short video, social media, and internet game use were assessed using validated scales, and PA level was measured using the Physical Activity Rating Scale-3. Latent profile analysis was performed to identify PIU profiles. Multinomial logistic regression was used to examine the associations between PA levels and profile membership after adjusting for sociodemographic characteristics. RESULTS: Four heterogeneous latent profiles of problematic internet use were identified among college students: the Low-risk problematic use profile (n = 1,630, 61.28%), the Social media-dominant problematic use profile (n = 304, 11.43%), the Gaming-dominant problematic use profile (n = 478, 17.97%), and the High-risk problematic use profile (n = 248, 9.32%). Multinomial logistic regression analyses showed that, compared with the Low-risk profile, male students had higher odds of membership in the Gaming-dominant profile (OR = 2.122, 95%CI:1.697-2.654) and the High-risk profile (OR = 1.714, 95%CI:1.292-2.273), but lower odds of membership in the Social media-dominant profile (OR = 0.767, 95%CI:0.598-0.983). Sophomore and junior students had significantly higher odds of membership in all three non-low-risk profiles, whereas senior students had significantly lower odds. Off-campus residence was associated with lower odds of membership in the Gaming-dominant profile (OR = 0.508, 95%CI:0.298-0.864). High-level physical activity was associated with lower odds of membership in the Social media-dominant (OR = 0.585, 95%CI:0.395-0.866), Gaming-dominant (OR = 0.371, 95%CI:0.255-0.539), and High-risk profiles (OR = 0.552, 95%CI:0.353-0.862). Moderate-level physical activity was associated with lower odds of membership only in the Gaming-dominant profile (OR = 0.795, 95%CI:0.632-0.999). CONCLUSION: PIU among college students exhibits substantial heterogeneity. The observed associations between PA levels and profile membership may inform targeted PIU prevention strategies. CI - Copyright (c) 2026 Peng, Zhou and Chen. FAU - Peng, Wenzhi AU - Peng W AD - Department of Physical Education Teaching and Research, Central South University, Changsha, Hunan, China. FAU - Zhou, Zeng AU - Zhou Z AD - Department of Physical Education Teaching and Research, Central South University, Changsha, Hunan, China. AD - College of Sports Science, Jishou University, Jishou, Hunan, China. FAU - Chen, Ziyi AU - Chen Z AD - College of Physical Education and Health, Guangxi Normal University, Guilin, Guangxi, China. LA - eng PT - Journal Article DEP - 20260727 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Male MH - *Students/statistics & numerical data/psychology MH - Cross-Sectional Studies MH - *Exercise MH - Female MH - Young Adult MH - China/epidemiology MH - Universities MH - *Internet Addiction Disorder/epidemiology MH - *Internet Use/statistics & numerical data MH - Surveys and Questionnaires MH - Adolescent MH - *Behavior, Addictive/epidemiology MH - Digital Media MH - Video Games/statistics & numerical data PMC - PMC13453751 OTO - NOTNLM OT - behavioral addiction OT - college students OT - latent profiles OT - physical activity levels OT - problematic internet use COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/11 06:35 MHDA- 2026/08/11 12:37 PMCR- 2026/07/27 CRDT- 2026/08/11 05:32 PHST- 2026/02/26 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/11 12:37 [medline] PHST- 2026/08/11 06:35 [pubmed] PHST- 2026/08/11 05:32 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1818418 [doi] PST - epublish SO - Front Public Health. 2026 Jul 27;14:1818418. doi: 10.3389/fpubh.2026.1818418. eCollection 2026. PMID- 42576292 OWN - NLM STAT- Publisher LR - 20260811 IS - 1601-5037 (Electronic) IS - 1601-5029 (Linking) DP - 2026 Aug 10 TI - Impact of an Educational Video Intervention on Word Recognition and Vocabulary Knowledge of Paediatric Dental Terms Among Low-Income Caregivers of Young Children. LID - 10.1111/idh.70147 [doi] AB - OBJECTIVE: To evaluate the impact of an educational intervention on paediatric dental term recognition and vocabulary knowledge among low-income caregivers of young children. METHODS: A randomized two-group pretest-posttest trial was used to analyze the impact of an educational intervention on caregivers' word recognition and vocabulary knowledge of paediatric dental terms. The study included 60 pregnant women and caregivers with children enrolled in a Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) in the Southeastern United States. Both groups received an educational pamphlet on children's oral health. The experimental group also received an educational video with common paediatric dental terms (e.g., fluoride, decay). The validated Oral Health Literacy Inventory for Parents (OH-LIP) measured word recognition and vocabulary knowledge for 36 paediatric dental terms. Scoring of the inventory was completed by two researchers. RESULTS: Baseline OH-LIP scores for Part I (word recognition) were high in both groups, with a median (IQR) of 95.83 (11.11). In contrast, baseline OH-LIP scores for Part II (vocabulary knowledge) were low to moderate, with a mean (SD) of 39.24 (14.06). In regression analysis, there was no evidence that the intervention significantly improved knowledge scores before (p = 0.62) or after (p = 0.33) adjusting for baseline characteristics. Baseline vocabulary knowledge scores were the strongest predictor of post-intervention scores (p < 0.001). CONCLUSIONS: OH-LIP Part I and II scores changed modestly, but there was no statistically significant difference between groups post-intervention among low-income pregnant women and caregivers. These findings highlight the need for developing and testing different modalities, such as one-to-one education or in-person group education, to improve OHL. CI - (c) 2026 The Author(s). International Journal of Dental Hygiene published by John Wiley & Sons Ltd. FAU - Sullivan, Melissa L AU - Sullivan ML AUID- ORCID: 0009-0006-0176-4856 AD - Gene W. Hirschfeld School of Dental Hygiene, Ellmer College of Health Sciences, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, USA. FAU - McKinney, Denise C AU - McKinney DC AD - Gene W. Hirschfeld School of Dental Hygiene, Ellmer College of Health Sciences, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, USA. FAU - Al-Taiar, Abdullah AU - Al-Taiar A AUID- ORCID: 0000-0001-7421-3381 AD - Joint School of Public Health, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, USA. FAU - Shuman, Deanne AU - Shuman D AD - Gene W. Hirschfeld School of Dental Hygiene, Ellmer College of Health Sciences, Macon & Joan Brock Virginia Health Sciences at Old Dominion University, Norfolk, Virginia, USA. LA - eng PT - Journal Article DEP - 20260810 PL - England TA - Int J Dent Hyg JT - International journal of dental hygiene JID - 101168070 SB - IM OTO - NOTNLM OT - Women, Infants, and Children (WIC) OT - caregivers OT - early childhood caries (ECC) OT - health services research OT - intervention OT - oral health literacy (OHL) OT - public health EDAT- 2026/08/11 06:35 MHDA- 2026/08/11 06:35 CRDT- 2026/08/11 00:43 PHST- 2026/06/04 00:00 [revised] PHST- 2025/10/10 00:00 [received] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/11 06:35 [medline] PHST- 2026/08/11 06:35 [pubmed] PHST- 2026/08/11 00:43 [entrez] AID - 10.1111/idh.70147 [doi] PST - aheadofprint SO - Int J Dent Hyg. 2026 Aug 10. doi: 10.1111/idh.70147. PMID- 42575069 OWN - NLM STAT- MEDLINE DCOM- 20260829 LR - 20260829 IS - 1873-3379 (Electronic) IS - 0891-4222 (Linking) VI - 176 DP - 2026 Sep TI - The longitudinal relationship between physical activity and social skills in children with autism: Basic psychological need satisfaction in exercise as a potential pathway. PG - 105362 LID - S0891-4222(26)00157-5 [pii] LID - 10.1016/j.ridd.2026.105362 [doi] AB - OBJECTIVE: To examine the longitudinal association between physical activity and social skills in children with autism and evaluate basic psychological need satisfaction in exercise as a potential longitudinal indirect pathway. METHODS: A three-wave longitudinal study was conducted in seven special education schools in Sichuan, Hunan, and Yunnan, China. Data were collected in November 2025, February 2026, and May 2026 at three-month intervals. Primary caregivers completed all questionnaires. After excluding attrition cases and invalid responses, 584 valid cases were retained. Physical activity, basic psychological need satisfaction in exercise, and social skills were assessed using validated Chinese scales. Measurement invariance testing and fixed-effect cross-lagged panel modeling were supplemented by a longitudinal latent-variable model, demographic- and physical-activity-scaling sensitivity analyses, and random-effects cross-lagged panel modeling. RESULTS: The preliminary bivariate CLPM showed inadequate global fit; therefore, its path coefficients were not used for substantive inference. In the primary three-variable longitudinal model, physical activity showed consistent positive prospective associations with social skills across both adjacent intervals (beta = 0.274 and 0.169, respectively; both p < 0.001). T1 physical activity was positively associated with T2 basic psychological need satisfaction in exercise (beta = 0.105, p = 0.002), which was subsequently associated with higher T3 social skills (beta = 0.188, p < 0.001). This pathway yielded a small positive standardized indirect effect (effect = 0.020, 95% CI [0.007, 0.039], p = 0.015). The directly estimated association between T1 physical activity and T3 social skills also remained positive (effect = 0.137, 95% CI [0.068, 0.213], p < 0.001), indicating that basic psychological need satisfaction in exercise accounted for part, but not all, of the longitudinal association. The focal indirect effect was replicated in the longitudinal latent-variable, covariate-adjusted, and alternative physical-activity-scoring analyses, with estimates ranging from 0.022 to 0.029. The targeted random-effects model yielded a comparable point estimate (0.022), although with greater uncertainty (95% CI [-0.012, 0.056]). CONCLUSION: These findings position physical activity as a recurring developmental context associated with later social-skill development in children with autism and indicate that basic psychological need satisfaction in exercise may modestly help explain this longitudinal relationship. They further suggest that the social-developmental relevance of physical activity may depend partly on whether participation supports autonomy, competence, and relatedness, underscoring the importance of considering the psychological quality of participation alongside activity volume. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Chen, Longjiang AU - Chen L AD - School of Physical Education, Yunnan Normal University, Kunming, China. Electronic address: longjiang-chen@outlook.com. FAU - Mei, Zhengyang AU - Mei Z AD - School of Physical Education, Central China Normal University, Wuhan, China. Electronic address: meizhengyang0823@126.com. FAU - Cai, Chenyi AU - Cai C AD - School of Physical Education, Southwest University, Chongqing, China. Electronic address: caichenyi2002@126.com. FAU - Yin, Tian AU - Yin T AD - School of Physical Education, Yunnan Minzu University, Kunming, China. Electronic address: shanliangdenanzihan@ymu.edu.cn. FAU - Xiang, Yian AU - Xiang Y AD - Department of Rehabilitation Medicine, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China. Electronic address: xyian@126.com. LA - eng PT - Journal Article DEP - 20260810 PL - United States TA - Res Dev Disabil JT - Research in developmental disabilities JID - 8709782 SB - IM MH - Humans MH - Male MH - Longitudinal Studies MH - Female MH - Child MH - *Exercise/psychology MH - *Social Skills MH - *Personal Satisfaction MH - *Autistic Disorder/psychology MH - China MH - Education, Special MH - *Autism Spectrum Disorder/psychology MH - Surveys and Questionnaires OTO - NOTNLM OT - Basic psychological need satisfaction in exercise OT - Children with autism OT - Longitudinal study OT - Physical activity OT - Social skills COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/11 00:35 MHDA- 2026/08/29 23:35 CRDT- 2026/08/10 18:10 PHST- 2026/06/20 00:00 [received] PHST- 2026/07/23 00:00 [revised] PHST- 2026/08/05 00:00 [accepted] PHST- 2026/08/29 23:35 [medline] PHST- 2026/08/11 00:35 [pubmed] PHST- 2026/08/10 18:10 [entrez] AID - S0891-4222(26)00157-5 [pii] AID - 10.1016/j.ridd.2026.105362 [doi] PST - ppublish SO - Res Dev Disabil. 2026 Sep;176:105362. doi: 10.1016/j.ridd.2026.105362. Epub 2026 Aug 10. PMID- 42574849 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260825 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 269 DP - 2026 Sep TI - Drivers of sustainable sport behavior in university students: Model development and validation. PG - 107572 LID - S0001-6918(26)01373-9 [pii] LID - 10.1016/j.actpsy.2026.107572 [doi] AB - This study developed and evaluated an integrative model of sustainable sport behavior among university students, defined as a theoretically linked but noninterchangeable pair of outcomes: maintenance of sport and physical activity participation and eco-aligned sport choices. Drawing on the Theory of Planned Behavior (TPB), self-regulation, motivation, social influence, and ecological perspectives, the study examined the confirmatory contribution of core TPB constructs and the incremental contribution of selected psychological, social, environmental, and sustainability-related factors. A two-phase design was used. In Phase 1, newly developed items measuring eco-aligned sport choices, visible sustainability practices, and perceived gendered/cultural barriers were reviewed by experts, refined through cognitive interviews, and examined using exploratory factor analysis with 284 students. In Phase 2, confirmatory factor analysis, measurement invariance testing, and structural equation modeling were conducted with 948 undergraduate students; 412 students provided behavior data at an eight-week follow-up. The measurement analyses supported two related first-order dimensions; a second-order score was retained for concise reporting, although the correlated two-factor solution showed a small fit advantage. Perceived behavioral control showed the largest association with intention, and T1 intention was prospectively associated with T2 behavior after baseline behavior was considered. Self-efficacy, perceived competence, intrinsic motivation, peer support, scheduling compatibility, access, physical environment quality, and visible sustainability practices showed additional, generally small associations. Statistical indirect associations through stress and anxiety were interpreted cautiously. Measurement invariance was evaluated for women and men and across academic stage. The findings indicate that sustainable sport behavior is associated with both individual regulation and inclusive, accessible, schedule-sensitive, and visibly sustainable campus conditions; however, the 43.5% follow-up retention, self-report measurement, and the observational nature of most paths limit causal inference. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Chen, Xiao AU - Chen X AD - Faculty of Sports Science and Technology, Bangkok Thonburi University, Bangkok, Thailand. Electronic address: chenxiao2152@outlook.com. FAU - Esmaeili, Ali AU - Esmaeili A AD - Allameh Tabataba'i University, Tehran, Iran. Electronic address: ali.esmaeili@atu.ac.ir. LA - eng PT - Journal Article PT - Validation Study DEP - 20260810 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM MH - Humans MH - *Students/psychology MH - Female MH - Universities MH - Theory of Planned Behavior MH - *Sports/psychology MH - *Motivation MH - Male MH - Young Adult MH - Self Efficacy MH - Adult MH - Intention MH - Self-Control MH - *Models, Psychological MH - Adolescent MH - *Exercise/psychology OTO - NOTNLM OT - Campus sustainability OT - Motivation OT - Perceived behavioral control OT - Physical activity OT - Structural equation modeling OT - Sustainable sport behavior OT - University students COIS- Declaration of competing interest The authors declare that they have no competing interests. EDAT- 2026/08/11 00:35 MHDA- 2026/08/25 05:34 CRDT- 2026/08/10 18:02 PHST- 2026/06/15 00:00 [received] PHST- 2026/07/31 00:00 [revised] PHST- 2026/07/31 00:00 [accepted] PHST- 2026/08/25 05:34 [medline] PHST- 2026/08/11 00:35 [pubmed] PHST- 2026/08/10 18:02 [entrez] AID - S0001-6918(26)01373-9 [pii] AID - 10.1016/j.actpsy.2026.107572 [doi] PST - ppublish SO - Acta Psychol (Amst). 2026 Sep;269:107572. doi: 10.1016/j.actpsy.2026.107572. Epub 2026 Aug 10. PMID- 42574428 OWN - NLM STAT- MEDLINE DCOM- 20260810 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 8 DP - 2026 TI - Moving Kindergartens: Protocol for a 10-week feasibility study. PG - e0354826 LID - 10.1371/journal.pone.0354826 [doi] LID - e0354826 AB - OBJECTIVE: The primary aim of this study is to evaluate the feasibility of a proposed intervention designed to support the daily movement practices and fostering joy of movement in Danish kindergartens, as well as the implementation strategies intended to facilitate adoption. Additionally, the feasibility of the planned measurement and procedures for a future effectiveness study will be examined. METHODS: The study uses a mixed-methods design to examine the feasibility of the intervention and the evaluation design. The planned duration of the intervention period is 10 weeks. The intervention consists of multiple integrated components co-designed with pedagogical staff, leaders, experts in kindergarten movement culture, and a team of researchers, to collectively support the daily movement practice in kindergartens. Alongside the intervention components, tailored strategies are developed to facilitate adoption and implementation. The intervention elements are categorized into four main types: 1) Formal establishment of the project; 2) Components of physical activity integrated in existing structures in the kindergarten; 3) Organizational and staff training; 4) Inspirational materials, tools and exemplary plans. DISCUSSION: The use of a co-design approach in close collaboration between kindergartens, experts, and a team of researchers will ensure contextual relevance and shared ownership. This approach is expected to enhance acceptability, feasibility, and sustainability of the intervention. The mixed-methods evaluation design, use of theoretical implementation frameworks, and tailored strategies further strengthen the study. The findings from this feasibility study will inform the refinement of the final intervention and guide the planning of a forthcoming effectiveness study. CI - Copyright: (c) 2026 Bandak et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Bandak, Elisabeth AU - Bandak E AD - Department of Midwifery, Physiotherapy, Occupational Therapy and Psychomotor Therapy, University College Copenhagen, Copenhagen, Denmark. AD - Centre for Better Childhoods, University College Copenhagen, Copenhagen, Denmark. FAU - Jeppesen, Lise Sohl AU - Jeppesen LS AD - Department of Midwifery, Physiotherapy, Occupational Therapy and Psychomotor Therapy, University College Copenhagen, Copenhagen, Denmark. AD - Centre for Better Childhoods, University College Copenhagen, Copenhagen, Denmark. FAU - Sederberg, Mathilde AU - Sederberg M AD - Centre for Better Childhoods, University College Copenhagen, Copenhagen, Denmark. FAU - Pawlowski, Charlotte Skau AU - Pawlowski CS AD - Centre for Better Childhoods, University College Copenhagen, Copenhagen, Denmark. AD - Active Living Research Unit, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Bugge, Anna AU - Bugge A AUID- ORCID: 0000-0002-8345-1434 AD - Department of Midwifery, Physiotherapy, Occupational Therapy and Psychomotor Therapy, University College Copenhagen, Copenhagen, Denmark. AD - Centre for Better Childhoods, University College Copenhagen, Copenhagen, Denmark. LA - eng PT - Journal Article DEP - 20260810 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Feasibility Studies MH - *Schools MH - Child, Preschool MH - Denmark MH - *Exercise MH - Research Design PMC - PMC13456249 COIS- The authors have declared that no competing interests exist. EDAT- 2026/08/10 18:36 MHDA- 2026/08/10 18:37 PMCR- 2026/08/10 CRDT- 2026/08/10 13:34 PHST- 2025/12/12 00:00 [received] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/10 18:37 [medline] PHST- 2026/08/10 18:36 [pubmed] PHST- 2026/08/10 13:34 [entrez] PHST- 2026/08/10 00:00 [pmc-release] AID - PONE-D-25-65081 [pii] AID - 10.1371/journal.pone.0354826 [doi] PST - epublish SO - PLoS One. 2026 Aug 10;21(8):e0354826. doi: 10.1371/journal.pone.0354826. eCollection 2026. PMID- 42573896 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260810 LR - 20260813 IS - 2948-2801 (Electronic) IS - 2948-2801 (Linking) VI - 4 IP - 3 DP - 2026 Aug 10 TI - A safety-aware intake modeling framework for translating edible algal biomass into nutritional bioproducts. LID - 10.1007/s44307-026-00129-4 [doi] LID - 32 AB - Edible algal biomass has emerged as a promising platform for nutritional bioproduct development, but its practical translation depends on compositional variability, intake feasibility, and safety constraints. Here, we integrated biochemical profiling, trace element screening, age-specific intake modeling, and community consumption context to evaluate commercially available and supplier-provided microalgal and seaweed products within realistic application boundaries. Selected products differed substantially in macronutrient composition, fatty acid profiles, pigments, polyphenols, and mineral composition, indicating product- and species-specific roles as nutritional biomass rather than interchangeable ingredients. Across species and age groups, approximately 0.7 to 3.1 g dry biomass provided 20% of age-specific alpha-linolenic acid intake, with approximately 1 g sufficient for several products. Multi-species allocations improved omega-3 representation while remaining within practical intake limits and trace element-based screening thresholds. Community consumption data from Pacific Island children showed low and episodic seaweed intake, highlighting a gap between biomass potential and routine dietary use. These findings support safety-aware modeling as a preliminary screening and decision-support strategy for evaluating edible algal biomass before further product-specific validation. CI - (c) 2026. The Author(s). FAU - Wang, Yu AU - Wang Y AD - Department of Molecular Biosciences and Bioengineering, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. FAU - Roell, Garrett AU - Roell G AD - Department of Molecular Biosciences and Bioengineering, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. FAU - Cruz, Rica Dela AU - Cruz RD AD - Department of Human Nutrition, Food and Animal Sciences, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. FAU - Durdakova, Michaela AU - Durdakova M AD - Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, 61300, Brno, Czech Republic. AD - Research Center for Applied Molecular Oncology, Masaryk Memorial Cancer Institute, Zluty Kopec 7, 65653, Brno, Czech Republic. FAU - Maruwan, Jessica AU - Maruwan J AD - Department of Molecular Biosciences and Bioengineering, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. FAU - Rong, Kexin AU - Rong K AD - Water Resources Research Center, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. FAU - Novotny, Rachel AU - Novotny R AD - Department of Human Nutrition, Food and Animal Sciences, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. FAU - Esquivel, Monica AU - Esquivel M AD - Department of Human Nutrition, Food and Animal Sciences, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. FAU - Wilkens, Lynne AU - Wilkens L AD - University of Hawai'i Cancer Center, Honolulu, Hawai'i, 96822, USA. FAU - Su, Wei Wen AU - Su WW AD - Department of Molecular Biosciences and Bioengineering, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. FAU - Yan, Tao AU - Yan T AD - Water Resources Research Center, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. FAU - Ho, Kacie AU - Ho K AD - Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, 61300, Brno, Czech Republic. FAU - Du, Zhi-Yan AU - Du ZY AUID- ORCID: 0000-0001-7646-2429 AD - Department of Molecular Biosciences and Bioengineering, University of Hawai'i at Manoa, Honolulu, Hawai'i, 96822, USA. duz@hawaii.edu. LA - eng GR - 23-FY23-HA-5047H-DU/University of Hawai'i at Manoa/ GR - 2022-38500-38099/National Institute of Food and Agriculture/ GR - 2021-333/Institute of Clinical and Translational Sciences/ PT - Journal Article DEP - 20260810 PL - Singapore TA - Adv Biotechnol (Singap) JT - Advanced biotechnology JID - 9918821788106676 PMC - PMC13457825 OTO - NOTNLM OT - Algal biotechnology OT - Edible algal biomass OT - Microalgae OT - Nutritional bioproducts OT - Omega-3 fatty acids OT - Safety-aware modeling COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: The work described has not been published before and is not under consideration for publication elsewhere. All co-authors have approved the final version. Competing interests: Author Z.-Y.D. is member of the Editorial Board for Advanced Biotechnology, and the author is not involved in the journal's review and decisions related to this manuscript. EDAT- 2026/08/10 12:36 MHDA- 2026/08/10 12:37 PMCR- 2026/08/10 CRDT- 2026/08/10 11:21 PHST- 2026/05/20 00:00 [received] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/07/26 00:00 [revised] PHST- 2026/08/10 12:37 [medline] PHST- 2026/08/10 12:36 [pubmed] PHST- 2026/08/10 11:21 [entrez] PHST- 2026/08/10 00:00 [pmc-release] AID - 10.1007/s44307-026-00129-4 [pii] AID - 129 [pii] AID - 10.1007/s44307-026-00129-4 [doi] PST - epublish SO - Adv Biotechnol (Singap). 2026 Aug 10;4(3):32. doi: 10.1007/s44307-026-00129-4. PMID- 42572679 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260810 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 7 DP - 2026 Jul TI - Comparison of YouTube Videos and Artificial Intelligence Chatbot Responses Regarding Pediatric Pelvic Floor Dysfunction: A Cross-Sectional Infodemiology Study. PG - e112387 LID - 10.7759/cureus.112387 [doi] LID - e112387 AB - BACKGROUND: Pediatric pelvic floor dysfunction is a common cause of lower urinary tract symptoms and bowel dysfunction in children, requiring accurate and reliable educational resources for patients and caregivers. With the increasing use of online health information, both YouTube (Google LLC, Mountain View, CA, USA) and artificial intelligence (AI) chatbots have become frequently used sources of medical guidance. This study aimed to evaluate and compare the educational quality, reliability, and safety of YouTube videos and AI-generated responses related to pediatric pelvic floor dysfunction. MATERIALS AND METHODS: In this cross-sectional infodemiology study, YouTube was searched using five predefined pediatric pelvic floor-related search terms, and the first 50 videos for each term were screened. After duplicate removal and eligibility assessment, 25 videos were included for analysis. Three publicly available AI chatbots (ChatGPT (OpenAI, San Francisco, CA, USA), Gemini (Google LLC, Mountain View, CA, USA), and Copilot (Microsoft Corporation, Redmond, WA, USA)) were evaluated using a standardized set of 20 pediatric pelvic floor-related questions. Educational quality was independently assessed using the DISCERN instrument, the Global Quality Scale (GQS), and the Pediatric Pelvic Floor Education and Reliability Score (PPFERS), a pediatric-specific assessment tool developed for this study. RESULTS: The 25 included YouTube videos accumulated 447,398 total views. Physiotherapists or pediatric physical therapists were the most common content creators (44.0%), followed by healthcare institutions (28.0%). The mean DISCERN, GQS, and PPFERS scores for YouTube videos were 66.24 +/- 8.64, 4.28 +/- 0.74, and 16.88 +/- 1.96, respectively. Among AI chatbots, Gemini achieved the highest educational quality scores (76.00 +/- 1.92, 4.95 +/- 0.22, and 19.35 +/- 0.59), followed by ChatGPT (74.20 +/- 2.40, 4.85 +/- 0.37, and 18.60 +/- 0.82) and Copilot (67.85 +/- 2.03, 4.35 +/- 0.49, and 17.10 +/- 0.72). Overall, AI-generated responses demonstrated higher mean educational quality scores than the YouTube video cohort. CONCLUSIONS: Both YouTube videos and AI-generated responses provided generally useful educational information regarding pediatric pelvic floor dysfunction. However, AI chatbots, particularly Gemini and ChatGPT, demonstrated greater educational consistency and closer alignment with contemporary pediatric urotherapy principles. AI-assisted educational tools may serve as valuable adjuncts to patient and caregiver education but should complement, rather than replace, professional medical evaluation and individualized clinical guidance. CI - Copyright (c) 2026, Altinok et al. FAU - Altinok, Volkan AU - Altinok V AD - Department of Pediatric Surgery, Ordu Universitesi, Ordu, TUR. FAU - Altinok, Ecem I AU - Altinok EI AD - Department of Pediatrics, Ordu Universitesi, Ordu, TUR. LA - eng PT - Journal Article DEP - 20260710 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13453056 OTO - NOTNLM OT - ai-based chatbots OT - artificial intelligence in medicine OT - dysfunctional voiding OT - pediatrics and child health OT - pelvic floor dysfunction OT - pelvic floor exercise OT - youtube videos COIS- Human subjects: All authors have confirmed that this study did not involve human participants or tissue. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/08/10 06:37 MHDA- 2026/08/10 06:38 PMCR- 2026/07/10 CRDT- 2026/08/10 03:51 PHST- 2026/07/09 00:00 [accepted] PHST- 2026/08/10 06:38 [medline] PHST- 2026/08/10 06:37 [pubmed] PHST- 2026/08/10 03:51 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - 10.7759/cureus.112387 [doi] PST - epublish SO - Cureus. 2026 Jul 10;18(7):e112387. doi: 10.7759/cureus.112387. eCollection 2026 Jul. PMID- 42572658 OWN - NLM STAT- MEDLINE DCOM- 20260810 LR - 20260826 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Effects of exercise interventions on adolescents with mild to moderate scoliosis: a meta-analysis. PG - e21355 LID - 10.7717/peerj.21355 [doi] LID - e21355 AB - BACKGROUND: Adolescent idiopathic scoliosis (AIS) is a prevalent spinal deformity that impairs physical function and quality of life. While supervised exercise is recommended for moderate cases, its effectiveness remains debated. This meta-analysis evaluates the impact of exercise therapy on Cobb angle, trunk rotation (ATR), and quality of life (QoL) in AIS patients. METHODS: We systematically searched PubMed, Web of Science, EBSCO and China National Knowledge Infrastructure (CNKI) databases from inception to October 2025 for randomized controlled trials (RCTs) investigating exercise in AIS. Study quality was assessed using the PEDro scale. Data synthesis involved pooling effect sizes, conducting subgroup analyses, and assessing publication bias using Stata 18. RESULTS: A total of 26 studies (21 RCT and five controlled trials) were included in the meta-analysis. The exercise intervention demonstrated statistically significant improvements across multiple functional domains: reduced the Cobb angle (Hedge's = 1.22, 95% CI [0.90-1.53]), improved the ATR (Hedge's systematically searched 1.25, 95% CI [0.74-1.76]), and enhanced QoL (Hedge's systematically searched 0.73, 95% CI [0.38-1.09]). Subgroup analyses further indicated that Schroth-based training (Hedge's = 1.304) and combined approaches (e.g., exercise with orthotic management) yielded the most favorable outcomes. Importantly, both short-term (/=25 weeks, >/=5 sessions/week) intervention durations demonstrated significant clinical efficacy. CONCLUSION: Exercise therapy demonstrates significant potential as a fundamental conservative intervention for improving spinal morphology, function, and quality of life in adolescents with idiopathic scoliosis. The current evidence supports its integration into primary clinical management protocols. Future research should focus on conducting multi-center randomized controlled trials to validate long-term efficacy and to establish optimal, individualized intervention protocols. CI - (c)2026 Liu et al. FAU - Liu, Qing AU - Liu Q AD - School of Physical Education, Central China Normal University, Wuhan, China. FAU - Xu, Chengli AU - Xu C AD - School of Physical Education, Central China Normal University, Wuhan, China. FAU - Li, Jia AU - Li J AD - School of Physical Education, Central China Normal University, Wuhan, China. FAU - Tian, Jing AU - Tian J AD - School of Physical Education, Central China Normal University, Wuhan, China. FAU - Xue, Chenxu AU - Xue C AD - Hebei Academy of Fine Arts, Shijiazhuang, China. FAU - Yu, Tenghao AU - Yu T AD - College of Life Science, Henan Normal University, Xinxiang, China. FAU - Dong, Kuan AU - Dong K AD - School of Physical Education, Central China Normal University, Wuhan, China. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260806 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - *Scoliosis/therapy MH - Adolescent MH - *Exercise Therapy/methods MH - *Quality of Life MH - Randomized Controlled Trials as Topic MH - Treatment Outcome PMC - PMC13453138 OTO - NOTNLM OT - Adolescent scoliosis OT - Axial trunk rotation OT - Cobb angle OT - Exercise interventions OT - Meta-analysis OT - Quality of life COIS- The authors declare there are no competing interests. EDAT- 2026/08/10 06:37 MHDA- 2026/08/10 06:38 PMCR- 2026/08/06 CRDT- 2026/08/10 03:50 PHST- 2025/07/14 00:00 [received] PHST- 2026/04/15 00:00 [accepted] PHST- 2026/08/10 06:38 [medline] PHST- 2026/08/10 06:37 [pubmed] PHST- 2026/08/10 03:50 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 21355 [pii] AID - 10.7717/peerj.21355 [doi] PST - epublish SO - PeerJ. 2026 Aug 6;14:e21355. doi: 10.7717/peerj.21355. eCollection 2026. PMID- 42571161 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260809 LR - 20260826 IS - 2325-9671 (Print) IS - 2325-9671 (Electronic) IS - 2325-9671 (Linking) VI - 14 IP - 8 DP - 2026 Aug TI - Association of Mental Health, Quality of Life, and Sport Specialization Using the Wisconsin Sport Specialization Questionnaire Among Adolescent Athletes. PG - 23259671261467554 LID - 10.1177/23259671261467554 [doi] LID - 23259671261467554 AB - BACKGROUND: Higher sport specialization levels have been associated with increased mental health issues. A recently validated questionnaire, the Wisconsin Sport Specialization Questionnaire (WISSQ), may provide clarity about the degree of sport specialization to investigate associations with mental health/quality of life (QoL) among adolescent athletes. PURPOSE: To examine the association of sports specialization, as measured by the WISSQ, and mental health/QoL outcomes among uninjured adolescent athletes, as well as the effect of age on the interaction between mental health/QoL outcomes and sport specialization. STUDY DESIGN: Cross-sectional study; Level of evidence, 2. METHODS: During the preseason assessment, performed in July and August from 2023 to 2025, participants completed the WISSQ and the Patient-Reported Outcomes Measurement Information System (PROMIS) Global 25 (Version 1.1). A multiple linear regression model was constructed that evaluated the association between 6 PROMIS domains and WISSQ ratings, adjusting for age, sex, and self-reported physical activity volume. To address the secondary purpose, linear regression models with an interaction term were used to examine the association between each PROMIS domain and age with sport specialization. RESULTS: A total of 251 uninjured adolescent athletes completed the study (mean +/- SD age, 15.9 +/- 1.4 years). The mean WISSQ rating was 54.1 (SD, 15.4). Results from the multivariable linear regression model indicated that higher depressive symptoms (beta = 0.46; 95% CI, 0.16-0.76; P = .003) and pain interference ratings (beta = 0.30; 95% CI, 0.02-0.57; P = .03) were significantly associated with higher WISSQ ratings, after adjusting for baseline physical activity, age, sex, and history of anxiety or depression diagnosis. For the secondary purpose, there was a significant interaction between fatigue and age group on sport specialization (beta coefficient = 0.49; 95% CI, 0.02-0.95; P = .04). The relationship between fatigue and sport specialization differed by age: a stronger association occurred among older adolescents than younger adolescents. There were no other age x QoL interactions. CONCLUSION: This study demonstrated that higher depressive symptoms and pain interference ratings were significantly associated with higher WISSQ ratings. In addition, there was a significant interaction between fatigue and age group, with a stronger association identified among older adolescents. Higher specialized and older adolescent athletes may be more at risk for developing mental health/QoL concerns and may benefit from more targeted screening. CI - (c) The Author(s) 2026. FAU - Meyers, Rachel AU - Meyers R AD - Sports Medicine Center, Children's Hospital Colorado, Aurora, Colorado, USA. FAU - Petersen, Sarah AU - Petersen S AD - Sports Medicine Center, Children's Hospital Colorado, Aurora, Colorado, USA. AD - Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Hogg-Cornejo, Veronica AU - Hogg-Cornejo V AD - Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Sweeney, Emily AU - Sweeney E AUID- ORCID: 0000-0002-5546-4668 AD - Sports Medicine Center, Children's Hospital Colorado, Aurora, Colorado, USA. AD - Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Armento, Aubrey AU - Armento A AD - Sports Medicine Center, Children's Hospital Colorado, Aurora, Colorado, USA. AD - Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Howell, David AU - Howell D AUID- ORCID: 0000-0002-2955-0191 AD - Sports Medicine Center, Children's Hospital Colorado, Aurora, Colorado, USA. AD - Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Walker, Gregory AU - Walker G AD - Sports Medicine Center, Children's Hospital Colorado, Aurora, Colorado, USA. AD - Department of Orthopedics, University of Colorado School of Medicine, Aurora, Colorado, USA. LA - eng GR - R13 AR080451/AR/NIAMS NIH HHS/United States GR - UL1 TR002535/TR/NCATS NIH HHS/United States GR - R01 NS100952/NS/NINDS NIH HHS/United States GR - K12 TR004412/TR/NCATS NIH HHS/United States GR - R03 HD094560/HD/NICHD NIH HHS/United States GR - UM1 TR004399/TR/NCATS NIH HHS/United States GR - R43 NS108823/NS/NINDS NIH HHS/United States PT - Journal Article DEP - 20260806 PL - United States TA - Orthop J Sports Med JT - Orthopaedic journal of sports medicine JID - 101620522 PMC - PMC13451724 OTO - NOTNLM OT - WISSQ OT - adolescence OT - mental health OT - sport specialization COIS- One or more of the authors has declared the following potential conflict of interest or source of funding: Research reported in this publication was supported by the Denver Broncos Foundation. The funding source played no role in the research design, data collection, data analysis, or interpretation of results. Unrelated to this study, D.H. has received research support from the Eunice Kennedy Shriver National Institute of Child Health and Human Development (R03HD094560,), the National Institute of Neurological Disorders and Stroke (R01NS100952, R43NS108823), the National Institute of Arthritis and Musculoskeletal and Skin Diseases (1R13AR080451), the 59th Medical Wing Department of the Air Force, MINDSOURCE Brain Injury Network, the Tai Foundation, and the Colorado Clinical and Translational Sciences Institute (UL1 TR002535-05). A.A. has received funding from the National Center for Advancing Translational Sciences/Clinical and Translational Science Awards Program/Colorado Clinical and Translational Sciences Institute (K12 TR004412, UM1 TR004399). EDAT- 2026/08/09 06:41 MHDA- 2026/08/09 06:42 PMCR- 2026/08/06 CRDT- 2026/08/09 03:58 PHST- 2026/06/15 00:00 [received] PHST- 2026/06/21 00:00 [accepted] PHST- 2026/08/09 06:42 [medline] PHST- 2026/08/09 06:41 [pubmed] PHST- 2026/08/09 03:58 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - 10.1177_23259671261467554 [pii] AID - 10.1177/23259671261467554 [doi] PST - epublish SO - Orthop J Sports Med. 2026 Aug 6;14(8):23259671261467554. doi: 10.1177/23259671261467554. eCollection 2026 Aug. PMID- 42570575 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260926 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 204 DP - 2026 Nov TI - Ultrasound-based area ossification ratios for pediatric radiographic bone age: Development and internal validation of a radiation-free nomogram. PG - 113135 LID - S0720-048X(26)00483-3 [pii] LID - 10.1016/j.ejrad.2026.113135 [doi] AB - PURPOSE: Radiographic bone age (BA) assessment involves ionizing radiation, limiting its utility in frequent longitudinal follow-up. This study developed and internally validated a radiation-free nomogram based on multi-site two-dimensional ultrasound area ossification ratios (ORs) to assess Zhonghua-05 (RUS-CHN) radiographic bone age and predicted adult height (PAH), evaluating its incremental value over chronological age. METHODS: In this single-center prospective study (August 2024 approximately December 2025), 1,053 children aged 3-15 years were randomized into training and validation sets (7:3). Ultrasound area ORs of the left distal radius, ulna, and femur were calculated. Using radiographic RUS-CHN BA as the reference standard, predictor variables were selected via LASSO regression to construct the nomogram. Model performance was evaluated across the cohort and within developmental discordance subgroups (advanced/delayed maturation). RESULTS: Ultrasound OR measurements showed excellent reproducibility (ICC > 0.88). In the validation set, the nomogram predicted RUS-CHN BA with a mean absolute error (MAE) of 2.94 months (RMSE = 3.67 months, R(2) = 0.989). Crucially, in children with advanced or delayed maturation, the nomogram reduced BA prediction MAE by over 60 % compared to a baseline clinical feature model. The secondary model for PAH achieved an MAE of 0.63 cm. CONCLUSIONS: Multi-site ultrasound area ORs provide a highly reproducible, radiation-free index of skeletal maturity. As an internally validated, standard-specific research tool, the nomogram estimated RUS-CHN radiographic BA and corrected age-anchoring bias in children with discordant maturation. Because its numeric calibration is specific to the RUS-CHN standard, external multicenter and longitudinal validation is required before clinical use. ABBREVIATIONS: BA, Bone age; BMI, Body mass index; CI, Confidence interval; GP, Greulich Pyle; ICC, Intraclass correlation coefficient; LASSO, Least absolute shrinkage and selection operator; LoA, Limits of agreement; MAE, Mean absolute error; MPH, Mid‑parental height; OR, Area ossification ratio; PAH, Predicted adult height; QC, Quality control; RMSE, Root mean square error; RUS‑CHN, Radius, ulna, and short bones RUS skeletal‑maturity score, Chinese standard; SOP, Standard operating procedure; TRIPOD, Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Deng, Yongzhi AU - Deng Y AD - School of Medical Technology, Qiqihar Medical University, Qiqihar, Heilongjiang 161006, China. FAU - Qiang, Lu AU - Qiang L AD - Department of Radiology, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, China. FAU - Wang, Tailong AU - Wang T AD - Department of Ultrasound, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, China. FAU - Zheng, Haijun AU - Zheng H AD - Department of Radiology, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, China. FAU - He, Yucheng AU - He Y AD - Department of Radiology, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, China. FAU - Li, Yifang AU - Li Y AD - Academy for Engineering and Technology, Fudan University, Shanghai 200433, China. FAU - Zhu, Weihong AU - Zhu W AD - Department of Ultrasound, The First People's Hospital of Chenzhou, Chenzhou, Hunan 423000, China. Electronic address: zhu_wei_hong@126.com. FAU - Li, Yudan AU - Li Y AD - Department of Ultrasound, The Third People's Hospital of Shenzhen, Shenzhen, Guangdong 518000, China. Electronic address: liyudan2026@163.com. LA - eng PT - Journal Article PT - Validation Study DEP - 20260805 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 SB - IM MH - Humans MH - *Age Determination by Skeleton/methods MH - *Nomograms MH - Child MH - Ultrasonography/methods MH - Reproducibility of Results MH - Child, Preschool MH - Female MH - Male MH - *Osteogenesis/physiology MH - Adolescent MH - Prospective Studies OTO - NOTNLM OT - Area ossification ratio OT - Bone age OT - LASSO OT - Nomogram OT - Predicted adult height OT - RUS-CHN OT - Ultrasound COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/09 00:43 MHDA- 2026/09/26 05:34 CRDT- 2026/08/08 18:07 PHST- 2026/06/17 00:00 [received] PHST- 2026/07/25 00:00 [revised] PHST- 2026/08/04 00:00 [accepted] PHST- 2026/09/26 05:34 [medline] PHST- 2026/08/09 00:43 [pubmed] PHST- 2026/08/08 18:07 [entrez] AID - S0720-048X(26)00483-3 [pii] AID - 10.1016/j.ejrad.2026.113135 [doi] PST - ppublish SO - Eur J Radiol. 2026 Nov;204:113135. doi: 10.1016/j.ejrad.2026.113135. Epub 2026 Aug 5. PMID- 42570559 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261009 IS - 1528-3984 (Electronic) IS - 0197-4572 (Linking) VI - 73 DP - 2026 Oct TI - Post-pandemic aging in Taiwan: Social networks, intergenerational relationships, and quality of life. PG - 104218 LID - S0197-4572(26)00423-4 [pii] LID - 10.1016/j.gerinurse.2026.104218 [doi] AB - PURPOSE: In Taiwan's post-COVID-19 context, universal National Health Insurance (NHI) and broad provider choice may contribute to information asymmetries that influence how older adults seek and navigate care. This cross-sectional study examined the associations among social network support (SNS), intergenerational relationships (IRs), healthcare-seeking behavior attitudes (HSBA), and quality of life (QoL) in community-dwelling older adults in northern Taiwan. METHODS: A total of 150 participants (mean age = 73.5 +/- 5.9 years) completed a newly developed and validated HSBA scale, a validated SNS instrument culturally adapted for older adults, a culturally adapted and validated IR measure, and a Taiwan-specific QoL measure. Analyses included descriptive statistics, Pearson correlations, prespecified subgroup comparisons, and multivariable linear regression analyses (two-tailed alpha = .05). RESULTS: All variables were positively correlated. QoL showed the strongest association with SNS (r = 0.64, p < .001), followed by IRs (r = 0.51) and HSBA (r = 0.29). In the multivariable models, regular exercise independently predicted higher HSBA, SNS, and QoL, whereas stronger IRs were associated with having more grandchildren and receiving daily telephone contact from non-cohabiting children. CONCLUSIONS: Among community-dwelling older adults in northern Taiwan, SNS was the strongest correlate of QoL. The findings support the inclusion of social connectedness, exercise participation, and intergenerational contact in routine gerontological nursing assessment. Because this study used a cross-sectional design, no causal or intervention-related interpretations can be made. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Wu, Hsiao-Ying AU - Wu HY AD - Department of Nursing, Chang Gung University of Science and Technology, No. 261 Wenhua 1st Rd. Guishan District, Taoyuan City, 333, R.O.C., Taiwan. Electronic address: hywu@mail.cgust.edu.tw. LA - eng PT - Journal Article DEP - 20260808 PL - United States TA - Geriatr Nurs JT - Geriatric nursing (New York, N.Y.) JID - 8309633 SB - IM MH - Humans MH - Taiwan/epidemiology MH - *Quality of Life/psychology MH - Aged MH - Cross-Sectional Studies MH - Female MH - *Intergenerational Relations MH - Male MH - *Social Support MH - Pandemics MH - Aged, 80 and over MH - *Patient Acceptance of Health Care/statistics & numerical data MH - *Aging/psychology MH - Independent Living MH - Surveys and Questionnaires OTO - NOTNLM OT - Healthcare-seeking behavior OT - Intergenerational relationships OT - Older adults OT - Quality of life OT - Social networks COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/09 00:43 MHDA- 2026/10/09 05:30 CRDT- 2026/08/08 18:07 PHST- 2025/12/29 00:00 [received] PHST- 2026/05/28 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/10/09 05:30 [medline] PHST- 2026/08/09 00:43 [pubmed] PHST- 2026/08/08 18:07 [entrez] AID - S0197-4572(26)00423-4 [pii] AID - 10.1016/j.gerinurse.2026.104218 [doi] PST - ppublish SO - Geriatr Nurs. 2026 Oct;73:104218. doi: 10.1016/j.gerinurse.2026.104218. Epub 2026 Aug 8. PMID- 42551383 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260825 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 269 DP - 2026 Sep TI - Fatigue in adolescent girls is linked to heavy menstrual bleeding, meal skipping and nicotine use - not iron deficiency. PG - 107568 LID - S0001-6918(26)01369-7 [pii] LID - 10.1016/j.actpsy.2026.107568 [doi] AB - Fatigue is common among adolescent girls, and iron deficiency is often considered a potential contributing factor. However, the association between iron status and self-reported fatigue in this population remains insufficiently understood. In a cross-sectional study of 485 post-menarchal girls aged 15-19 years, we examined associations between iron status, menstrual health, lifestyle factors, fatigue, and quality of life. Participants completed validated measures of fatigue (Pediatric Quality of Life Multidimensional Fatigue Scale) and quality of life (KIDSCREEN-10), and provided blood samples for ferritin and hemoglobin assessment. Iron deficiency was present in 37.7% of participants and anemia in 7.7%. Neither iron deficiency nor anemia was associated with fatigue or quality of life in crude analyses. In contrast, heavy menstrual bleeding, daily nicotine use, and skipping breakfast or school lunch were associated with higher fatigue and lower quality of life. After adjustment for potential confounders, higher ferritin and hemoglobin levels were associated with greater fatigue, while heavy menstrual bleeding remained consistently associated with fatigue. These findings suggest that fatigue in adolescent girls is more closely related to menstrual health and everyday behavioral factors than to iron status. The results support a multidimensional perspective on adolescent fatigue and highlight the importance of considering behavioral and psychosocial influences when assessing fatigue and well-being. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Stubbendorff, Anna AU - Stubbendorff A AD - Nutritional Epidemiology, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden. Electronic address: anna.stubbendorff@med.lu.se. FAU - Borgfors, Alice AU - Borgfors A AD - Center for Primary Health Care Research, Department of Clinical Sciences, Malmo, Lund University, Sweden; University Clinic Primary Care Skane, Region Skane, Sweden. FAU - Bolmsjo, Beata Borgstrom AU - Bolmsjo BB AD - Center for Primary Health Care Research, Department of Clinical Sciences, Malmo, Lund University, Sweden; University Clinic Primary Care Skane, Region Skane, Sweden. FAU - Vinge, Fredrik AU - Vinge F AD - Center for Primary Health Care Research, Department of Clinical Sciences, Malmo, Lund University, Sweden; University Clinic Primary Care Skane, Region Skane, Sweden. FAU - Midlov, Patrik AU - Midlov P AD - Center for Primary Health Care Research, Department of Clinical Sciences, Malmo, Lund University, Sweden; University Clinic Primary Care Skane, Region Skane, Sweden. FAU - Wolff, Moa AU - Wolff M AD - Center for Primary Health Care Research, Department of Clinical Sciences, Malmo, Lund University, Sweden; University Clinic Primary Care Skane, Region Skane, Sweden. LA - eng PT - Journal Article DEP - 20260804 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 RN - 9007-73-2 (Ferritins) SB - IM MH - Humans MH - Female MH - Adolescent MH - *Fatigue/epidemiology/etiology/blood MH - Cross-Sectional Studies MH - Quality of Life MH - *Iron Deficiencies MH - *Menorrhagia/epidemiology/complications MH - Ferritins/blood MH - Young Adult MH - *Anemia, Iron-Deficiency/epidemiology MH - *Tobacco Use/epidemiology MH - *Feeding Behavior/physiology OTO - NOTNLM OT - Adolescent OT - Fatigue OT - Heavy menstrual bleeding, nicotine, diet OT - Iron deficiency OT - Teenage COIS- Declaration of competing interest All authors declare no competing interests. EDAT- 2026/08/09 15:21 MHDA- 2026/08/25 05:34 CRDT- 2026/08/04 18:10 PHST- 2026/06/09 00:00 [received] PHST- 2026/07/27 00:00 [revised] PHST- 2026/07/30 00:00 [accepted] PHST- 2026/08/25 05:34 [medline] PHST- 2026/08/09 15:21 [pubmed] PHST- 2026/08/04 18:10 [entrez] AID - S0001-6918(26)01369-7 [pii] AID - 10.1016/j.actpsy.2026.107568 [doi] PST - ppublish SO - Acta Psychol (Amst). 2026 Sep;269:107568. doi: 10.1016/j.actpsy.2026.107568. Epub 2026 Aug 4. PMID- 42551214 OWN - NLM STAT- MEDLINE DCOM- 20261001 LR - 20261001 IS - 1532-2130 (Electronic) IS - 1090-3798 (Linking) VI - 64 DP - 2026 Sep TI - Total bilirubin-to-albumin ratio and systemic immune inflammation index as prognostic indicators in children with febrile infection-related epilepsy syndrome. PG - 20-32 LID - S1090-3798(26)00082-6 [pii] LID - 10.1016/j.ejpn.2026.07.009 [doi] AB - OBJECTIVE: Febrile infection-related epilepsy syndrome (FIRES) is associated with high mortality and poor neurological outcomes, yet reliable prognostic indicators are lacking. This study aimed to evaluate the prognostic value of inflammatory indexes in FIRES and to explore their potential role in guiding clinical management. METHODS: Children with FIRES hospitalized at the Children's Hospital affiliated to Chongqing Medical University between November 2015 and April 2024 and followed for more than 6 months were retrospectively included. Inflammatory indexes were analyzed at admission and after immunotherapy. Patients were categorized into death, KD, and non-KD survival groups according to clinical course and treatment pathway. Multivariate logistic and sequential logistic regression analyses were performed to identify prognostic factors. Receiver operating characteristic (ROC) curves and Gordon's coefficient were used to determine cut-off values. Sankey diagrams and nomograms were applied to validate prognostic stratification. RESULTS: Thirty-six children with FIRES were included (22 males; mean age 6.67 +/- 3 years). Nine patients died, none of whom received KD. The KD group had significantly higher 6-month Glasgow Outcome Scale (GOS) scores than the non-KD survival and death groups (4 +/- 1 vs. 3 +/- 1 vs. 1 +/- 0, p < 0.001). Multivariate analyses showed that total bilirubin-to-albumin ratio (TAR) at admission (18.48, 95% CI 6.86 approximately 30.09, p = 0.002) and systemic immune inflammation index (SII) after immunotherapy (-0.001, 95% CI -0.001-0, p = 0.003) were independently associated with prognosis. Cut-off values of 0.145 and 0.195 for TAR and 1292 and 1892 for SII stratified patients into distinct severity groups. Higher TAR values and lower SII values were associated with milder disease and better outcomes. Sankey diagrams and nomograms further illustrated the prognostic stratification based on TAR and SII. CONCLUSION: TAR at admission and SII after immunotherapy are practical inflammatory indexes associated with disease severity and prognosis in FIRES. These findings support further investigation of early KD initiation, particularly in patients with low TAR at admission or persistently elevated SII after immunotherapy. CI - Copyright (c) 2026 European Paediatric Neurology Society. Published by Elsevier Ltd. All rights reserved. FAU - Wang, Juan AU - Wang J AD - Department of Neurology, Children's Hospital of Chongqing Medical University, China; National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China. FAU - Cheng, Min AU - Cheng M AD - Department of Neurology, Children's Hospital of Chongqing Medical University, China; National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China. FAU - Liu, Yongfang AU - Liu Y AD - Department of Nutrition, Children's Hospital of Chongqing Medical University, China; National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China. FAU - Liu, Yuhang AU - Liu Y AD - Department of Neurology, Children's Hospital of Chongqing Medical University, China; National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China. FAU - Xie, Lingling AU - Xie L AD - Department of Neurology, Children's Hospital of Chongqing Medical University, China; National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China. Electronic address: lingling_xie@hospital.cqmu.edu.cn. FAU - Jiang, Li AU - Jiang L AD - Department of Neurology, Children's Hospital of Chongqing Medical University, China; National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, China. Electronic address: dr_jiangcqmu@163.com. LA - eng PT - Journal Article DEP - 20260728 PL - England TA - Eur J Paediatr Neurol JT - European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society JID - 9715169 RN - RFM9X3LJ49 (Bilirubin) RN - 0 (Serum Albumin) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Male MH - Prognosis MH - *Bilirubin/blood MH - Retrospective Studies MH - Child, Preschool MH - *Inflammation/blood MH - Child MH - *Epileptic Syndromes/blood/diagnosis MH - Infant MH - *Serum Albumin/metabolism MH - *Seizures, Febrile/blood/diagnosis MH - Biomarkers/blood OTO - NOTNLM OT - Febrile infection-related epilepsy syndrome OT - Inflammation OT - Ketogenic diet OT - Prognostic biomarkers OT - Systemic immune inflammation index COIS- Conflict of interest statement The authors declare that there are no conflicts of interest regarding the publication of this paper. EDAT- 2026/08/09 15:21 MHDA- 2026/10/01 23:30 CRDT- 2026/08/04 18:05 PHST- 2026/01/07 00:00 [received] PHST- 2026/04/17 00:00 [revised] PHST- 2026/07/28 00:00 [accepted] PHST- 2026/10/01 23:30 [medline] PHST- 2026/08/09 15:21 [pubmed] PHST- 2026/08/04 18:05 [entrez] AID - S1090-3798(26)00082-6 [pii] AID - 10.1016/j.ejpn.2026.07.009 [doi] PST - ppublish SO - Eur J Paediatr Neurol. 2026 Sep;64:20-32. doi: 10.1016/j.ejpn.2026.07.009. Epub 2026 Jul 28. PMID- 42570408 OWN - NLM STAT- MEDLINE DCOM- 20260822 LR - 20260822 IS - 1873-4162 (Electronic) IS - 1344-6223 (Linking) VI - 85 DP - 2026 Sep TI - The relationship between postmortem heart weight and morphometric measurements and body mass index: an investigation of forensic autopsy cases. PG - 102916 LID - S1344-6223(26)00144-6 [pii] LID - 10.1016/j.legalmed.2026.102916 [doi] AB - The postmortem evaluation of heart weight and morphometric measurements presents challenges, highlighting the need for reliable reference values. This study aimed to establish population-specific data for the Turkish population. A retrospective analysis was performed on autopsy cases aged >/=18 years between January 1, 2018, and December 31, 2019, at the relevant forensic morgue department. Statistical analyses were conducted using the Number Cruncher Statistical System. Of the included cases, 20.2% were female and 79.8% male. The mean age and body mass index were 52.32 +/- 20.29 years and 28.34 +/- 7.29 kg/m(2) in females, and 46.86 +/- 17.06 years and 26.54 +/- 5.43 kg/m(2) in males. Heart weight increased with age up to 80 years in both sexes and was independently associated with body mass index in multivariable regression analysis. The mean heart weight was 507.08 +/- 129.12 g in cardiovascular-related deaths and 410.35 +/- 128.94 g in other natural deaths. In hearts without detected cardiac pathology, the mean weight was 277.74 g in females and 350.11 g in males. Average ventricular wall thickness was 0.31 cm (right) and 1.27 cm (left). Valve circumferences were larger in males. Multivariate regression analysis revealed moderate explanatory power (R(2) = 32.5% in cases with pathology and 48.0% in those without pathology) for heart weight. This study provides population-specific reference data for postmortem heart weight and morphometric parameters within the methodological framework of a retrospective autopsy cohort in the Turkish population. These findings may support forensic autopsy practice, though further studies are needed for validation. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Tat, Emrah AU - Tat E AD - The Group Presidency of Forensic Medicine, Council of Forensic Medicine, Ministry of Justice, Antalya, Turkiye. Electronic address: ab205132@adalet.gov.tr. FAU - Sogukpinar, Veysel Osman AU - Sogukpinar VO AD - The Group Presidency of Forensic Medicine, Council of Forensic Medicine, Ministry of Justice, Van, Turkiye. Electronic address: v.o.s23@hotmail.com. FAU - Arpak, Baha Berk AU - Arpak BB AD - The Council of Forensic Medicine, Ministry of Justice, Istanbul, Turkiye. Electronic address: bahaberk@gmail.com. FAU - Uzun, Ibrahim AU - Uzun I AD - The Council of Forensic Medicine, Ministry of Justice, Istanbul, Turkiye. Electronic address: ibrahim.uzun@iuc.edu.tr. LA - eng PT - Journal Article DEP - 20260708 PL - Ireland TA - Leg Med (Tokyo) JT - Legal medicine (Tokyo, Japan) JID - 100889186 SB - IM MH - Humans MH - Male MH - Female MH - Middle Aged MH - Aged MH - *Body Mass Index MH - Adult MH - Retrospective Studies MH - Organ Size MH - Aged, 80 and over MH - Autopsy MH - *Heart/anatomy & histology MH - Adolescent MH - Turkey MH - Young Adult MH - Forensic Pathology MH - Reference Values MH - *Myocardium/pathology OTO - NOTNLM OT - Body mass index OT - Forensic autopsy OT - Heart morphometric measurements OT - Heart weight OT - Reference values OT - Turkish population COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/08 23:10 MHDA- 2026/08/22 23:43 CRDT- 2026/08/08 18:01 PHST- 2026/02/03 00:00 [received] PHST- 2026/04/21 00:00 [revised] PHST- 2026/06/05 00:00 [accepted] PHST- 2026/08/22 23:43 [medline] PHST- 2026/08/08 23:10 [pubmed] PHST- 2026/08/08 18:01 [entrez] AID - S1344-6223(26)00144-6 [pii] AID - 10.1016/j.legalmed.2026.102916 [doi] PST - ppublish SO - Leg Med (Tokyo). 2026 Sep;85:102916. doi: 10.1016/j.legalmed.2026.102916. Epub 2026 Jul 8. PMID- 42569675 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260808 LR - 20260813 IS - 2667-3681 (Electronic) IS - 2667-3681 (Linking) VI - 19 DP - 2026 Sep TI - Creation and validation of the 8-Item Brief Emotional Eating Scale (BEES-8, version 1.0) in youth and adults. PG - 100307 LID - 10.1016/j.obpill.2026.100307 [doi] LID - 100307 AB - INTRODUCTION: Although several instruments have been developed to assess emotional eating, no measure has yet been identified that evaluates this construct based on the eight basic emotions. Assessing emotional eating is particularly important because it represents a relevant factor associated with overweight and obesity. In this context, the aim of the present study was to develop and validate the Brief Emotional Eating Scale based on the Eight Basic Emotions (BEES-8, version 1.0) in a sample of Peruvian youth and adults. METHODS: A cross-sectional psychometric study was conducted. The non-probabilistic sample consisted of 481 participants of both sexes, with a mean age of 31.72 years (SD = 12.08), recruited from Metropolitan Lima, Peru. The Brief Emotional Eating Scale (BEES-8, v1.0) and the Generalized Anxiety Disorder Scale (GAD-2) were administered. RESULTS: A second-order confirmatory factor analysis demonstrated an adequate model fit (CFI = 0.976, TLI = 0.962, SRMR = 0.029, RMSEA = 0.076). Furthermore, BEES-8 (v1.0) scores showed a positive and statistically significant correlation with generalized anxiety (r = 0.449, p < 0.001), providing evidence of validity based on relationships with other variables. Finally, the scale demonstrated adequate overall reliability (omega = 0.919). CONCLUSION: The BEES-8 (v1.0) demonstrated adequate evidence of validity and reliability for assessing emotional eating based on the eight basic emotions. It constitutes a potentially useful tool for research and for the study of eating behaviors associated with emotional states, as well as variables related to overweight, obesity, and emotional regulation. CI - (c) 2026 Published by Elsevier Inc. on behalf of Obesity Medicine Association. FAU - Javier-Aliaga, David AU - Javier-Aliaga D AD - Graduate School,Universidad Peruana Union, Lima, Peru. AD - Advanced Research Center in Neuroscience, Lifestyles, Gastrointestinal health, Obesity and Diabetes (ARCeNeLGOD), Lima, Peru. FAU - Quinteros-Zuniga, Damaris AU - Quinteros-Zuniga D AD - Graduate School,Universidad Peruana Union, Lima, Peru. LA - eng PT - Journal Article DEP - 20260724 PL - United States TA - Obes Pillars JT - Obesity pillars JID - 9918697364706676 PMC - PMC13450208 OTO - NOTNLM OT - Adult OT - Emotional eating OT - Factor analysis OT - Obesity OT - Validation OT - Young adult COIS- The authors declare no financial, institutional, employment, or personal conflicts of interest related to the preparation of this manuscript. EDAT- 2026/08/08 23:10 MHDA- 2026/08/08 23:11 PMCR- 2026/07/24 CRDT- 2026/08/08 06:32 PHST- 2026/06/19 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/08 23:11 [medline] PHST- 2026/08/08 23:10 [pubmed] PHST- 2026/08/08 06:32 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - S2667-3681(26)00063-X [pii] AID - 100307 [pii] AID - 10.1016/j.obpill.2026.100307 [doi] PST - epublish SO - Obes Pillars. 2026 Jul 24;19:100307. doi: 10.1016/j.obpill.2026.100307. eCollection 2026 Sep. PMID- 42569514 OWN - NLM STAT- MEDLINE DCOM- 20260808 LR - 20260903 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Personalized breathing recommendations for anxiety relief: a data-driven exploratory approach focusing on feasibility. PG - e21483 LID - 10.7717/peerj.21483 [doi] LID - e21483 AB - Breathing exercises are widely used to alleviate anxiety, but most interventions use fixed templates of inhalation, exhalation, and repetition. This study preliminarily explores the feasibility of data-driven personalization of breathing recommendations for general individuals. We hypothesized that based on the characteristics of individual users, a data-driven method could give a feasible breathing intervention suggestion without the need of specialized hardware. A multilayer perceptron was trained on questionnaire responses to predict the inhalation, exhalation, and repetition times. The model stability was assessed using several independently trained models and exhibited high consistency with coefficients of variation below 10% across all outputs. A single-blind randomized study (N = 820), which compared the personalized recommendations to a fixed template that is known to effectively reduce anxiety, measured the outcomes in terms of anxiety reduction and user-reported satisfaction. The main analysis and subgroup analysis both detected no statistically significant differences in effectiveness between model recommendation and fixed template after applying multiple comparison corrections. However, adults aged 18-30 years with the medium anxiety level showed a moderate exploratory preference for the fixed template. These findings indicate that individual characteristics may influence the preference of breathing interventions. Overall, the results highlight the feasibility of datadriven personalization in non-medical anxiety interventions. The outcomes can still be enhanced by various methods such as collecting more training data, fine-tuning on the model, or choosing advanced machine learning or offline reinforcement learning approaches. CI - (c)2026 Zhuo. FAU - Zhuo, Dongyin AU - Zhuo D AD - Munich, Bavaria, Germany. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260804 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - *Anxiety/therapy MH - Adult MH - Feasibility Studies MH - Female MH - Male MH - *Breathing Exercises/methods MH - Adolescent MH - Young Adult MH - Single-Blind Method MH - Surveys and Questionnaires MH - *Precision Medicine/methods PMC - PMC13450033 OTO - NOTNLM OT - Anxiety reduction OT - Deep learning OT - Personalization COIS- The authors declare there are no competing interests. EDAT- 2026/08/08 23:10 MHDA- 2026/08/08 23:11 PMCR- 2026/08/04 CRDT- 2026/08/08 06:25 PHST- 2026/01/23 00:00 [received] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/08/08 23:11 [medline] PHST- 2026/08/08 23:10 [pubmed] PHST- 2026/08/08 06:25 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - 21483 [pii] AID - 10.7717/peerj.21483 [doi] PST - epublish SO - PeerJ. 2026 Aug 4;14:e21483. doi: 10.7717/peerj.21483. eCollection 2026. PMID- 42568752 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260808 LR - 20260926 IS - 2048-7177 (Print) IS - 2048-7177 (Electronic) IS - 2048-7177 (Linking) VI - 14 IP - 8 DP - 2026 Aug TI - Vitamin E-Related Molecular Signatures in Adolescent Idiopathic Scoliosis: A Hypothesis-Generating Multi-Omics Analysis. PG - e72190 LID - 10.1002/fsn3.72190 [doi] LID - e72190 AB - Adolescent idiopathic scoliosis (AIS) involves systemic bone-metabolic dysregulation and paraspinal microenvironment remodeling, but whether nutrition-related micronutrient-associated molecular programs overlap with these alterations remains unclear. Vitamin E (VE), comprising lipid-soluble tocopherols and tocotrienols, is linked to membrane protection, lipid peroxidation control, inflammatory mediator regulation, and endothelial responses. This study examined whether VE-related molecular signatures converge on AIS-associated redox, lipid-inflammatory, vascular, and multicellular remodeling programs. Peripheral blood miRNA data (GSE235203) and bone marrow transcriptomic data (GSE110359) were integrated using HERB-based compound mapping, VE-AIS shared-target enrichment, feature prioritization, intradisease GSEA, single-cell localization, CellChat analysis, and NHANES contextualization. HERB mapping generated a VE/tocopherol-related prioritization signal, not direct evidence of VE involvement in AIS. Forty-two shared VE-AIS targets were enriched mainly in oxidative stress, glutathione/peroxidase activity, and glutathione metabolism, with additional lipid-inflammatory and vascular signals. Five prioritized genes (SOD1, GCLC, PTGS1, PTGS2, and KDR) defined redox-buffering, lipid-inflammatory, and vascular-response axes. Single-cell and CellChat analyses localized these signatures mainly to endothelial, dendritic/APC-like, MSC-like, and stromal/osteogenic populations, suggesting a predicted concave-side enrichment of inflammatory-endothelial-stromal communication. Structural analyses supported the computational plausibility of alpha-tocopherol compatibility with selected proteins, particularly PTGS2. No AIS cohort with measured VE exposure or status was analyzed. NHANES provided external clinical nutrition context rather than AIS-specific validation. Overall, VE-related signatures overlapped with redox, lipid-inflammatory, vascular-response, and multicellular remodeling programs in AIS. These findings generate testable molecular hypotheses but do not show that VE intake, tocopherol status, or supplementation modifies AIS risk, severity, or progression. CI - (c) 2026 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC. FAU - Ma, Ying AU - Ma Y AUID- ORCID: 0009-0008-9152-5609 AD - Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China. FAU - Han, Yuankun AU - Han Y AUID- ORCID: 0009-0004-4130-1886 AD - Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China. FAU - Geng, Zhizhong AU - Geng Z AUID- ORCID: 0000-0001-8000-4236 AD - Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China. FAU - Fang, Sitong AU - Fang S AUID- ORCID: 0009-0002-9463-8701 AD - Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China. FAU - Ren, Jun AU - Ren J AUID- ORCID: 0000-0002-4818-7746 AD - Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China. FAU - Wang, Shoujian AU - Wang S AUID- ORCID: 0009-0003-6319-6645 AD - Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China. FAU - He, Tianxiang AU - He T AD - Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China. FAU - Kong, Lingjun AU - Kong L AUID- ORCID: 0000-0002-6854-4202 AD - Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China. FAU - Fang, Min AU - Fang M AUID- ORCID: 0000-0001-5241-6460 AD - Shuguang Hospital Shanghai University of Traditional Chinese Medicine Shanghai China. AD - Institute of Tuina Shanghai Institute of Traditional Chinese Medicine Shanghai China. LA - eng PT - Journal Article DEP - 20260806 PL - United States TA - Food Sci Nutr JT - Food science & nutrition JID - 101605473 PMC - PMC13447955 OTO - NOTNLM OT - adolescent idiopathic scoliosis OT - oxidative stress OT - prostaglandin signaling OT - tocopherol OT - vascular response OT - vitamin E COIS- The authors declare no conflicts of interest. EDAT- 2026/08/08 12:52 MHDA- 2026/08/08 12:53 PMCR- 2026/08/06 CRDT- 2026/08/08 05:36 PHST- 2026/06/15 00:00 [received] PHST- 2026/07/10 00:00 [revised] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/08/08 12:53 [medline] PHST- 2026/08/08 12:52 [pubmed] PHST- 2026/08/08 05:36 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - FSN372190 [pii] AID - 10.1002/fsn3.72190 [doi] PST - epublish SO - Food Sci Nutr. 2026 Aug 6;14(8):e72190. doi: 10.1002/fsn3.72190. eCollection 2026 Aug. PMID- 42568636 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260808 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Sensory feeding problems, pica-related behaviors, and sleep habits among children with autism spectrum disorder in palestine: a parent-reported cross-sectional study. PG - 1899150 LID - 10.3389/fped.2026.1899150 [doi] LID - 1899150 AB - BACKGROUND: Autism Spectrum Disorder (ASD) is commonly associated with feeding difficulties and sleep disturbances, yet their co-occurrence remains understudied in Arab and Palestinian contexts. Pica and broader pica-related sensory feeding behaviors are among the most clinically significant feeding problems in children with ASD, carrying serious health risks. This study examined the level of parent-reported sensory feeding problems, pica-related behaviors, and sleep habit disturbances in children with ASD attending care centers in the West Bank, Palestine, and explored their association. METHODS: A cross-sectional descriptive-correlational survey was conducted. A convenience sample of 105 parents of children with ASD was recruited from care centers in the West Bank during August 2025. Two instruments were used: a 20-item literature-informed Sensory Feeding/Pica-Related Behaviors Scale developed for this study, and a 21-item Sleep Habits Scale adapted from the Arabic scale developed and validated by Al-Merdasi. The feeding scale underwent expert content review and pilot testing, while internal consistency was assessed for both instruments in the present sample. The feeding scale was designed to describe caregiver-reported sensory feeding difficulties and pica-related behaviors rather than to establish a DSM-5-TR or ICD-11 diagnosis of pica. All sleep items were coded so that higher scores indicated greater sleep disturbance; sleep adequacy items were reverse-scored. Data were analyzed using descriptive statistics, independent-samples t-tests, one-way ANOVA with LSD post-hoc tests, and Pearson correlation in SPSS. Effect sizes were reported as Cohen's d for t-tests and partial eta(2) for ANOVA. RESULTS: Sensory feeding problems and Pica-related behaviors scores were at a moderate level overall (M = 1.946, SD = 0.307; relative weight 64.9%). Sleep habit disturbances were also moderate (M = 3.123, SD = 0.551; 62.5%), with sleep anxiety ranking highest (M = 3.507). No significant differences in Sensory feeding and pica-related behavior scores were found by any demographic variable. For sleep habits, significant differences were found by child age (F = 10.038, p = 0.001, eta(2) = 0.164), with younger children appearing to score higher, though the oldest age group was small (n = 7) and the finding should be interpreted cautiously. Significant differences were also found by child sex (t = 2.195, p = 0.030, d = 0.43), with higher sleep disturbance scores among females. A significant positive moderate correlation was found between pica-related problem scores and sleep disturbance scores (r = 0.463, p < 0.001). CONCLUSIONS: This parent-reported cross-sectional study found moderate levels of sensory feeding problems, pica-related behaviors, and sleep disturbances among children with ASD in the West Bank, Palestine, and a significant positive association between them. Because the study used convenience sampling and researcher-developed instruments with preliminary validation only, findings should be interpreted as preliminary and should not be taken as estimates of clinically diagnosed pica or sleep disturbances. They highlight the importance of integrating screening for pica-like behaviors and sleep problems within ASD services, and support the need for future longitudinal studies incorporating clinical diagnosis, gastrointestinal assessment, nutritional biomarkers, and validated measures. CI - (c) 2026 Sabbah, Namoura, Yacoub, Yacoub and Yacoub. FAU - Sabbah, Suheir AU - Sabbah S AD - Psychology Department, Al-Quds University, Jerusalem, Palestine. FAU - Namoura, Sana M AU - Namoura SM AD - Psychology Department, Al-Quds University, Jerusalem, Palestine. FAU - Yacoub, Hamzeh AU - Yacoub H AD - Faculty of Medicine, Al-Quds University, Jerusalem, Palestine. AD - Faculty of Medicine, Arab American University, Ramallah, Palestine. FAU - Yacoub, Zaid AU - Yacoub Z AD - Faculty of Medicine, Al-Quds University, Jerusalem, Palestine. AD - SurgiCore-Jerusalem, Surgical Interest Group of Jerusalem, Faculty of Medicine, Al-Quds University, Jerusalem, Palestine. FAU - Yacoub, Rita AU - Yacoub R AD - Faculty of Medicine, Al-Quds University, Jerusalem, Palestine. LA - eng PT - Journal Article DEP - 20260724 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13447483 OTO - NOTNLM OT - autism spectrum disorder OT - cross-sectional study OT - feeding disorders OT - palestine OT - pica-related behaviors OT - sensory feeding problems OT - sensory processing OT - sleep habits COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/08 12:52 MHDA- 2026/08/08 12:53 PMCR- 2026/07/24 CRDT- 2026/08/08 05:28 PHST- 2026/06/03 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/08/08 12:53 [medline] PHST- 2026/08/08 12:52 [pubmed] PHST- 2026/08/08 05:28 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - 10.3389/fped.2026.1899150 [doi] PST - epublish SO - Front Pediatr. 2026 Jul 24;14:1899150. doi: 10.3389/fped.2026.1899150. eCollection 2026. PMID- 42568356 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260808 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Comparative profiling of amino acids in plasma and serum across children and adults using LC-MS/MS and its implications for precision nutrition. PG - 1850080 LID - 10.3389/fnut.2026.1850080 [doi] LID - 1850080 AB - OBJECTIVE: Circulating amino acids (AAs) are important biomarkers of nutritional status, metabolic homeostasis, and disease related physiological changes. However, the influence of specimen type and age on AA measurements remains incompletely understood. This study aimed to establish a robust liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for quantifying 29 amino acids (AAs), compare serum and plasma matrices, and investigate age related variations in healthy populations. METHODS: In a cross-sectional study, a total of 231 healthy adults (>/=18 years) and 140 children (<18 years) were recruited from the Shanghai area with a subgroup of 26 adults providing paired serum and plasma samples. Twenty-nine AA quantification was performed using LC-MS/MS with 6-aminoquinolyl-N-hydroxysuccinimidyl carbamate (AQC) derivatization. Method validation followed Clinical and Laboratory Standards Institute (CLSI) guidelines for linearity, lower limit of quantitation (LLOQ), precision, accuracy, carryover, and stability. RESULTS: The assay demonstrated excellent linearity (R (2) > 0.99), precision (CV < 15%), and accuracy (bias < 10%) with minimal carryover and acceptable LLOQs for all 29 AAs. Matrix differences and correlations were evaluated using the paired samples, while age related AA profiles were assessed in largely independent serum and plasma cohorts of pediatric and adult. Serum and plasma concentrations correlated well for most AA. However, significant matrix dependent differences were observed for several amino acids, including GABA, Ser, Tau, Sar, and Asp (R (2) < 0.5). Age related analysis revealed that most essential AAs (Leu, Ile, Trp, Phe, His, Tyr) exhibited higher median concentrations in children compared to adults in serum. Conversely, lysine and threonine were significantly higher in adult serum. In plasma, age related differences were less pronounced for essential AAs but consistent for specific non-essential AAs. Bubble plot showed Cit, Arg, and Gln were positively associated with age, while GABA was negatively associated with age. CONCLUSION: The validated LC-MS/MS platform provides a reliable platform for nutritional biomarker research. Matrix selection and age are critical factors in AA interpretation, offering valuable insights for clinical diagnostics and translational metabolomics research. CI - Copyright (c) 2026 Ma, Liu, Huangfu, Zhou and Zheng. FAU - Ma, Yanhui AU - Ma Y AD - Department of Laboratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Liu, Yi AU - Liu Y AD - Department of Laboratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Huangfu, Yuchan AU - Huangfu Y AD - Department of Laboratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhou, Yunlan AU - Zhou Y AD - Department of Laboratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zheng, Yingxia AU - Zheng Y AD - Department of Laboratory Medicine, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Faculty of Medical Laboratory Science, College of Health Science and Technology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Institute of Artificial Intelligence Medicine, Shanghai Academy of Experimental Medicine, Shanghai, China. LA - eng PT - Journal Article DEP - 20260724 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13447054 OTO - NOTNLM OT - LC-MS/MS OT - age OT - amino acids OT - fasting serum OT - plasma COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/08 12:52 MHDA- 2026/08/08 12:53 PMCR- 2026/07/24 CRDT- 2026/08/08 04:46 PHST- 2026/04/08 00:00 [received] PHST- 2026/06/24 00:00 [revised] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/08/08 12:53 [medline] PHST- 2026/08/08 12:52 [pubmed] PHST- 2026/08/08 04:46 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - 10.3389/fnut.2026.1850080 [doi] PST - epublish SO - Front Nutr. 2026 Jul 24;13:1850080. doi: 10.3389/fnut.2026.1850080. eCollection 2026. PMID- 42568265 OWN - NLM STAT- MEDLINE DCOM- 20260808 LR - 20260813 IS - 1467-7687 (Electronic) IS - 1363-755X (Print) IS - 1363-755X (Linking) VI - 29 IP - 5 DP - 2026 Sep TI - Detecting Young Children's Deception Using Facial Expression Analysis With High Dimensional Statistical Methods. PG - e70263 LID - 10.1111/desc.70263 [doi] LID - e70263 AB - Although deception is common in early childhood, accurately detecting deception remains a significant challenge. The present study aims to investigate the feasibility of using high-dimensional statistical methods to detect children's deception through facial expressions, with a focus on incorporating two time-dependent statistics: slope and fitness. We analyzed the facial expressions of 93 three- to six-year-old children during a guessing game. A machine vision algorithm (FACET) assessed the likelihood of nine basic facial expressions. We extracted three statistics (mean, slope and fitness) for each facial expression. Then, we used high-dimensional feature selection method to filter out irrelevant features. We adopted two parametric (logistic regression, linear discriminant analysis) and two non-parametric statistical methods (random forest, adaptive boosting) and tested both the full feature set ("full model") and the selected feature set ("2-step model"). The results showed adding time-dependent statistics (slope and fitness) improved performance, with the average balanced accuracy increasing from 47.2% to 62.0%. Feature selection further enhanced the model performance (from 60.8% to 63.3%). In addition, balanced accuracy provided a more conservative and reliable measure than the original accuracy (54.6% vs. 61.5%). These findings demonstrate the feasibility of using dynamic facial emotional features to detect deception in early childhood and highlight the potential of computational methods for advancing developmental research on emotion and social cognition. CI - (c) 2026 The Author(s). Developmental Science published by John Wiley & Sons Ltd. FAU - Wang, Wanjie AU - Wang W AD - Department of Statistics and Data Science, National University of Singapore, Singapore. FAU - Ding, Xiao Pan AU - Ding XP AD - Department of Psychology, National University of Singapore, Singapore, Singapore. FAU - Zhang, Xinran AU - Zhang X AD - Department of Statistics and Data Science, National University of Singapore, Singapore. FAU - Dai, Meng AU - Dai M AD - Department of Psychology, National University of Singapore, Singapore, Singapore. LA - eng GR - National University of Singapore (NUS) Start-up Grant/ GR - the NUS Centre for Family and Population Research Faculty Development Grant/ PT - Journal Article PL - England TA - Dev Sci JT - Developmental science JID - 9814574 SB - IM MH - Humans MH - *Facial Expression MH - *Deception MH - Child MH - Female MH - Child, Preschool MH - Male MH - Algorithms PMC - PMC13451778 OTO - NOTNLM OT - adaptive boosting OT - detecting deception OT - facial expression OT - feature selection OT - linear discriminant analysis OT - logistic regression OT - random forest COIS- The authors have no conflicts of interests to disclose. EDAT- 2026/08/08 12:52 MHDA- 2026/08/08 12:53 PMCR- 2026/08/08 CRDT- 2026/08/08 02:43 PHST- 2026/06/09 00:00 [revised] PHST- 2025/03/22 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/08/08 12:53 [medline] PHST- 2026/08/08 12:52 [pubmed] PHST- 2026/08/08 02:43 [entrez] PHST- 2026/08/08 00:00 [pmc-release] AID - DESC70263 [pii] AID - 10.1111/desc.70263 [doi] PST - ppublish SO - Dev Sci. 2026 Sep;29(5):e70263. doi: 10.1111/desc.70263. PMID- 42568081 OWN - NLM STAT- MEDLINE DCOM- 20260808 LR - 20260813 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Aug 8 TI - Digital odontometric analysis for sex estimation in Egyptian adolescents. LID - 10.1186/s12903-026-09486-x [doi] LID - 1384 AB - OBJECTIVES: Reliable sex estimation using dental metrics has important implications for clinical assessment and forensic identification, particularly in adolescents where skeletal indicators may be limited. This study aimed to validate the accuracy and clinical applicability of a digital odontometric model for sex estimation in an Egyptian adolescent population. METHODS: A total of 150 dental casts from individuals aged 12-19 years were digitized using a high-resolution three-dimensional scanner. Mesiodistal and buccolingual dimensions of the permanent first molars, mesiodistal widths of the maxillary canines, and intercanine, interpremolar, and intermolar arch widths were obtained using Facad Ortho tracing software. Statistical comparisons between sexes were performed, and discriminant function analysis was applied to construct and validate a predictive model for sex estimation. RESULTS: All measured parameters demonstrated significantly higher mean values in males compared with females (p < 0.05). The buccolingual and mesiodistal dimensions of the maxillary first molar exhibited the greatest sexual dimorphism (26.95% and 25.98%, respectively). The developed discriminant function model achieved a prediction accuracy of 97.8% for males and 100% for females. CONCLUSIONS: Digital odontometric analysis provides a promising approach for assessing sexual dimorphism in adolescents, pending external validation. This promising model may serve as a reliable adjunct for clinical evaluation and forensic identification within population-specific contexts pending further multicenter validation. CLINICAL RELEVANCE: Digital measurement of tooth and arch dimensions enables objective, standardized assessment of sex-related differences, supporting its integration into orthodontic diagnostics, treatment planning, and forensic casework where conventional skeletal indicators may be unavailable or inconclusive. CI - (c) 2026. The Author(s). FAU - Hadwa, Shimaa M AU - Hadwa SM AD - Pediatric Dentistry, Oral Health, and Preventive Dentistry Department, Faculty of Dentistry, Tanta University, Tanta, 31527, Egypt. shimaa.hadwa@dent.tanta.edu.eg. FAU - Alawy, Safa B AU - Alawy SB AD - Orthodontics Department, Faculty of Dentistry, Tanta University, Tanta, Egypt. FAU - Kabbash, Ibrahim A AU - Kabbash IA AD - Public Health & Community Medicine Department, Faculty of Medicine, Tanta University, Tanta, Egypt. FAU - El-Desouky, Shaimaa S AU - El-Desouky SS AD - Pediatric Dentistry, Oral Health, and Preventive Dentistry Department, Faculty of Dentistry, Tanta University, Tanta, 31527, Egypt. LA - eng PT - Journal Article PT - Validation Study DEP - 20260808 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - Adolescent MH - *Odontometry/methods MH - Egypt MH - Male MH - Child MH - Female MH - Young Adult MH - Imaging, Three-Dimensional MH - Discriminant Analysis MH - Models, Dental MH - Sex Characteristics MH - *Sex Determination Analysis/methods MH - Image Processing, Computer-Assisted MH - Dental Arch/anatomy & histology PMC - PMC13452096 OTO - NOTNLM OT - Arch width OT - Forensic odontology OT - Odontometric analysis OT - Sex OT - Sexual dimorphism COIS- Declarations. Ethical approval and consent to participate: Ethical approval for this study was obtained from the Research Ethics Committee, Faculty of Dentistry, Tanta University (Approval code: R-PED-5-24-3108), in accordance with the principles of the Declaration of Helsinki and its subsequent amendments. The study was retrospective and non-interventional in nature. Written informed consent to participate was obtained from all participants and/or their legal guardians at the time of record and dental cast collection, permitting the use of anonymized clinical data and models for research purposes. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/08/08 00:37 MHDA- 2026/08/08 12:52 PMCR- 2026/08/08 CRDT- 2026/08/07 23:57 PHST- 2026/01/17 00:00 [received] PHST- 2026/07/28 00:00 [accepted] PHST- 2026/08/08 12:52 [medline] PHST- 2026/08/08 00:37 [pubmed] PHST- 2026/08/07 23:57 [entrez] PHST- 2026/08/08 00:00 [pmc-release] AID - 10.1186/s12903-026-09486-x [pii] AID - 9486 [pii] AID - 10.1186/s12903-026-09486-x [doi] PST - epublish SO - BMC Oral Health. 2026 Aug 8;26(1):1384. doi: 10.1186/s12903-026-09486-x. PMID- 42568061 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20261027 IS - 2047-9980 (Electronic) IS - 2047-9980 (Linking) VI - 15 IP - 16 DP - 2026 Aug 18 TI - Dietary Approaches to Stop Hypertension Score Trajectories From Early to Middle Adulthood and Coronary Artery Calcium Progression in Middle Age. PG - e044564 LID - 10.1161/JAHA.125.044564 [doi] LID - e044564 AB - BACKGROUND: The Dietary Approaches to Stop Hypertension (DASH) diet reduces blood pressure and cardiovascular disease risk, but its impact on later coronary artery calcium (CAC) progression is unclear. This study aimed to identify DASH score trajectories from early to middle adulthood and assess their association with CAC progression in middle age, exploring the potential mediating factors. METHODS: We conducted a prospective analysis of 2238 Black and White adults who were aged 18 to 30 years at CARDIA (Coronary Artery Risk Development in Young Adults) baseline and were followed from study year 20 to year 25. DASH score trajectories from early to middle adulthood were determined using latent class analysis. The primary end point was CAC progression, a validated measure of plaque progression, defined as a >2.5 square root increase in CAC score between years 20 and 25. RESULTS: Two distinct DASH score trajectories were identified: the low-increasing and high-decreasing trajectories. In the fully adjusted model, participants in the high-decreasing trajectory had a 21% lower risk of CAC progression compared with those in the low-increasing trajectory (hazard ratio, 0.79 [95% CI, 0.65-0.98]; P=0.028). The association was partially mediated by diastolic blood pressure, insulin, uric acid, and lipid profiles. CONCLUSIONS: DASH score trajectories vary from early to middle adulthood. Maintaining high adherence to the DASH diet from early to middle adulthood is associated with reduced CAC progression in middle age, partially mediated by cardiometabolic risk factors. These findings support the importance of long-term adherence to a healthy dietary pattern for cardiovascular disease primary prevention. REGISTRATION: URL: https://www.clinicaltrials.gov; unique identifier: NCT00005130. FAU - Li, Xiong-Zhi AU - Li XZ AUID- ORCID: 0000-0001-8000-0227 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Xiong, Zhuo-Chao AU - Xiong ZC AUID- ORCID: 0000-0001-7520-409X AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Wang, Xin-Yi AU - Wang XY AUID- ORCID: 0009-0000-2285-6772 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Yu, Jin-Bo AU - Yu JB AUID- ORCID: 0000-0003-4341-3131 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Zhou, Jian AU - Zhou J AUID- ORCID: 0000-0002-5188-7129 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Zhong, Dong-Xiang AU - Zhong DX AUID- ORCID: 0000-0002-3997-7578 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Wu, Yi-Zhang AU - Wu YZ AUID- ORCID: 0000-0002-9693-8516 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Zhang, Bao-Wei AU - Zhang BW AUID- ORCID: 0000-0001-7043-0370 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Zhang, You-Ming AU - Zhang YM AUID- ORCID: 0000-0002-5014-8228 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Xia, Guang AU - Xia G AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Fan, Feng-Hua AU - Fan FH AUID- ORCID: 0009-0009-0049-6089 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Xie, Xin AU - Xie X AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Chen, Jie AU - Chen J AUID- ORCID: 0009-0003-2462-9559 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Song, Jie AU - Song J AUID- ORCID: 0009-0009-3238-4962 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Zhao, Jie AU - Zhao J AUID- ORCID: 0009-0004-3898-3505 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Li, Xiao-Rong AU - Li XR AUID- ORCID: 0000-0002-7295-655X AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. FAU - Yang, Bing AU - Yang B AUID- ORCID: 0000-0001-5042-9305 AD - Department of Cardiology Shanghai East Hospital, Tongji University School of Medicine Shanghai 200120 China. LA - eng SI - ClinicalTrials.gov/NCT00005130 PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20260807 PL - England TA - J Am Heart Assoc JT - Journal of the American Heart Association JID - 101580524 SB - IM MH - Humans MH - *Dietary Approaches To Stop Hypertension MH - Male MH - Disease Progression MH - Female MH - *Coronary Artery Disease/prevention & control/diagnostic imaging/epidemiology MH - Adult MH - Prospective Studies MH - *Vascular Calcification/prevention & control/diagnostic imaging/epidemiology MH - Young Adult MH - Adolescent MH - Middle Aged MH - Blood Pressure MH - Risk Factors MH - *Hypertension/diet therapy MH - Age Factors MH - *Coronary Vessels/diagnostic imaging MH - Risk Assessment MH - Time Factors MH - United States/epidemiology PMC - PMC13695727 OTO - NOTNLM OT - cardiometabolic risk OT - cardiovascular disease OT - coronary artery calcium OT - diet OT - dietary approaches to stop hypertension OT - primary prevention COIS- None. EDAT- 2026/08/08 00:37 MHDA- 2026/08/19 17:43 PMCR- 2026/08/07 CRDT- 2026/08/07 23:54 PHST- 2026/08/19 17:43 [medline] PHST- 2026/08/08 00:37 [pubmed] PHST- 2026/08/07 23:54 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - JAH370941 [pii] AID - 10.1161/JAHA.125.044564 [doi] PST - ppublish SO - J Am Heart Assoc. 2026 Aug 18;15(16):e044564. doi: 10.1161/JAHA.125.044564. Epub 2026 Aug 7. PMID- 42567969 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261014 IS - 1437-1596 (Electronic) IS - 0937-9827 (Linking) VI - 140 IP - 6 DP - 2026 Nov TI - First-stage assessment of AI-based anatomical measurement accuracy for the Cameriere European dental age estimation method. PG - 3951-3959 LID - 10.1007/s00414-026-03950-7 [doi] AB - AIM: This study represents the first methodological stage of a broader AI-assisted Cameriere European dental age estimation workflow. The aim of this first stage was to evaluate the performance of YOLOv8-based deep learning models in automatically detecting the anatomical landmarks and apical structures required for the Cameriere European method. Rather than directly estimating dental age, the proposed system was designed to automate the measurement-related inputs needed for subsequent Cameriere European-based age calculation. METHODS: This retrospective first-stage validation study included 4,050 panoramic radiographs of boys and girls aged 5-13 years. Two YOLOv8-based models were developed to automate the anatomical measurement components of the Cameriere European method: a YOLOv8x-pose model for open-apex landmark detection and tooth-length reference point localization, and a YOLOv8x-seg model for closed-apex segmentation. Owing to model-specific anatomical eligibility criteria, 3,796 images were used for the pose model and 2,971 images for the segmentation model. Image annotations were performed using CranioCatch software according to a standardized annotation protocol. Model outputs were compared with manual reference annotations to evaluate landmark detection, measurement-related localization, and apical segmentation performance. RESULTS: In the YOLOv8x-pose model, mAP_0.5 = 0.963 and mAP_0.5:0.95 = 0.842 were achieved; recall was 0.928 and precision was 0.918. Error metrics were MAE = 0.0032, RMSE = 0.0045, SMAPE = 2.09%, and the coefficient of determination R(2) = 0.9992. CONCLUSION: YOLOv8-based pose and segmentation models demonstrated technical feasibility for automating anatomical measurement extraction required for the Cameriere European dental age estimation method. Because dental age was not calculated in this first-stage analysis, the findings should be interpreted as measurement-level validation rather than complete dental age-estimation accuracy. Further validation is required to integrate AI-derived measurements into the Cameriere European formula and to compare AI-assisted dental age estimates with manual Cameriere-based assessment and chronological age. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Karauguz, Zehra Selin AU - Karauguz ZS AUID- ORCID: 0009-0007-6993-2585 AD - Department of Pediatric Dentistry, Faculty of Dentistry, Necmettin Erbakan University Yaka Mah, Beysehir Avenue, Baglarbasi Street No: 4, 42090, Meram, Konya, Turkiye. zehraselinkarauguz@gmail.com. FAU - Altan, Halenur AU - Altan H AUID- ORCID: 0000-0003-3648-5989 AD - Department of Pediatric Dentistry, Faculty of Dentistry, Necmettin Erbakan University Yaka Mah, Beysehir Avenue, Baglarbasi Street No: 4, 42090, Meram, Konya, Turkiye. LA - eng GR - 25DU24001/Necmettin Erbakan Universitesi/ PT - Journal Article PT - Validation Study DEP - 20260808 PL - Germany TA - Int J Legal Med JT - International journal of legal medicine JID - 9101456 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Child MH - Adolescent MH - Female MH - Child, Preschool MH - Radiography, Panoramic MH - Retrospective Studies MH - Male MH - *Anatomic Landmarks/diagnostic imaging MH - *Deep Learning MH - Image Processing, Computer-Assisted MH - Detection Algorithms MH - Tooth Apex/diagnostic imaging/growth & development OTO - NOTNLM OT - Artificial intelligence OT - Cameriere European method OT - Deep learning OT - Dental age estimation OT - YOLOv8 COIS- Declarations. Ethical approval: The study protocol was approved by the Non-Drug and Non-Medical Device Research Ethics Committee of the Faculty of Dentistry, Necmettin Erbakan University (Decision No: 2025/584; Meeting No: 51; Date: 24/04/2025). Informed consent: The requirement for informed consent was waived due to the retrospective nature of the study and the use of anonymized data. Research involving human participants and/or animals: This retrospective study involved previously collected radiographic data. Conflicts of interest: The authors declare that they have no conflict of interest. Data availability: The datasets generated and/or analysed during the current study are not publicly available due to institutional and ethical restrictions on patient radiographic data but are available from the corresponding author on reasonable request. EDAT- 2026/08/08 00:37 MHDA- 2026/10/12 17:30 CRDT- 2026/08/07 23:42 PHST- 2026/02/26 00:00 [received] PHST- 2026/08/01 00:00 [accepted] PHST- 2026/10/12 17:30 [medline] PHST- 2026/08/08 00:37 [pubmed] PHST- 2026/08/07 23:42 [entrez] AID - 10.1007/s00414-026-03950-7 [pii] AID - 10.1007/s00414-026-03950-7 [doi] PST - ppublish SO - Int J Legal Med. 2026 Nov;140(6):3951-3959. doi: 10.1007/s00414-026-03950-7. Epub 2026 Aug 8. PMID- 42567553 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260816 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 10 IP - 1 DP - 2026 Aug 7 TI - Context-specific predictors of mortality and the performance of paediatric sepsis scores in Tanzanian children: a secondary analysis of a prospective cohort study. LID - 10.1136/bmjpo-2026-004856 [doi] LID - e004856 AB - INTRODUCTION: Sepsis is a significant cause of global child mortality, disproportionately affecting resource-limited settings (RLS). Although clinical scores have been proposed in RLS, few have been externally validated. This study aimed to identify risk factors for mortality among Tanzanian children with sepsis and test three paediatric clinical scores in an RLS. METHODS: We conducted a secondary analysis of a prospective cohort study of 755 children (28 days to 14 years) with sepsis in the Emergency Department at Muhimbili National Hospital, Tanzania (July 2022-November 2024). Demographic, clinical and outcome data were collected. We performed multivariable logistic regression to identify independent predictors of in-hospital mortality. We then tested three clinical scores, Lambarene Organ Dysfunction Score (LODS), Blantyre quick Sequential Organ Failure Assessment (BqSOFA) and Phoenix Sepsis Score (PSS), using sensitivity, specificity and area under the receiver operating characteristic curve (AUC). RESULTS: In-hospital mortality was 20% (n=148); independent predictors included age, malnutrition, HIV status, referral status and delayed presentation (p<0.001). All three scores demonstrated strong discrimination for mortality (LODS AUC 0.79, 95% CI 0.75 to 0.83; BqSOFA AUC 0.75, 95% CI 0.71 to 0.79; PSS AUC 0.75, 95% CI 0.70 to 0.79) and differences between scores were not statistically significant (p=0.066). LODS showed high sensitivity (93%) and negative predictive value (96%). BqSOFA and PSS demonstrated high specificity (93% and 91%) and positive predictive values (51% and 56%), but low sensitivity (28% and 44%). CONCLUSIONS: Multiple clinical and sociodemographic factors were independently associated with mortality in children with sepsis. LODS demonstrated high sensitivity, while BqSOFA and PSS demonstrated high specificity; the scores' discriminative ability for mortality was not statistically significant. The identification of simple risk factors and moderately performing clinical scores provides a valuable opportunity to develop context-specific risk stratification tools for paediatric sepsis in RLS. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Sorensen, Abigail AU - Sorensen A AUID- ORCID: 0000-0001-8444-4968 AD - Pediatrics, UCSF, San Francisco, California, USA abigail.sorensen@ucsf.edu. FAU - Mussa, Raya AU - Mussa R AD - Emergency Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania. FAU - Sunzula, Erasto AU - Sunzula E AD - Emergency Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Mlele, Victoria AU - Mlele V AD - Emergency Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania. FAU - Oltman, Scott AU - Oltman S AD - Epidemiology and Biostatistics, UCSF, San Francisco, California, USA. FAU - Msemwa, Cecilia AU - Msemwa C AD - Emergency Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Mathias, Lushana AU - Mathias L AD - Emergency Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Baez-Maidana, Jazmin AU - Baez-Maidana J AD - Pediatrics, UCSF, San Francisco, California, USA. FAU - Sun, Kathleen AU - Sun K AD - Pediatrics, UCSF, San Francisco, California, USA. FAU - Mfinanga, Juma AU - Mfinanga J AD - Emergency Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania. FAU - Chu, Victoria AU - Chu V AD - Pediatrics, UCSF, San Francisco, California, USA. FAU - Hooft, Anneka AU - Hooft A AD - Emergency Medicine, UCSF, San Francisco, California, USA. FAU - Mkopi, Namala AU - Mkopi N AD - Emergency Medicine, Muhimbili National Hospital, Dar es Salaam, Tanzania. FAU - Kissoon, Niranjan AU - Kissoon N AD - Pediatrics, The University of British Columbia Faculty of Medicine, Vancouver, British Columbia, Canada. FAU - Manyahi, Joel AU - Manyahi J AD - Microbiology and Immunology, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Sawe, Hendry AU - Sawe H AD - Emergency Medicine, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Kortz, Teresa AU - Kortz T AD - Pediatrics, UCSF, San Francisco, California, USA. LA - eng GR - D43 TW009343/TW/FIC NIH HHS/United States GR - K23 AI144029/AI/NIAID NIH HHS/United States GR - T32 HD049303/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20260807 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Tanzania/epidemiology MH - *Sepsis/mortality/diagnosis MH - Female MH - Male MH - Prospective Studies MH - Child, Preschool MH - Infant MH - *Hospital Mortality MH - Child MH - Adolescent MH - Risk Factors MH - Organ Dysfunction Scores MH - Resource-Limited Settings MH - ROC Curve MH - Infant, Newborn MH - Severity of Illness Index MH - Predictive Value of Tests MH - Sensitivity and Specificity PMC - PMC13475138 OTO - NOTNLM OT - Child OT - Child Health OT - Developing Countries OT - Low and Middle Income Countries OT - Mortality COIS- Competing interests: None declared. EDAT- 2026/08/08 00:37 MHDA- 2026/08/08 00:38 PMCR- 2026/08/07 CRDT- 2026/08/07 20:43 PHST- 2026/04/13 00:00 [received] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/08/08 00:38 [medline] PHST- 2026/08/08 00:37 [pubmed] PHST- 2026/08/07 20:43 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - 10.1136/bmjpo-2026-004856 [pii] AID - bmjpo-2026-004856 [pii] AID - 10.1136/bmjpo-2026-004856 [doi] PST - epublish SO - BMJ Paediatr Open. 2026 Aug 7;10(1):e004856. doi: 10.1136/bmjpo-2026-004856. PMID- 42567538 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260813 IS - 1745-5065 (Electronic) IS - 1745-5057 (Print) IS - 1745-5057 (Linking) VI - 22 DP - 2026 Jan-Dec TI - A mixed methods analysis of a culturally responsive body image pilot intervention for black adolescent girls: Black girl joy. PG - 17455057261476900 LID - 10.1177/17455057261476900 [doi] LID - 17455057261476900 AB - BackgroundBlack adolescent girls develop body image within intersecting sociocultural contexts shaped by race, gender, and physical activity, yet few interventions are culturally and gender-responsive to their lived experiences.ObjectiveThis study examined the preliminary impact of Black Girl Joy, a culturally responsive body image and wellness pilot intervention, on psychosocial outcomes among Black adolescent girls.Study designExploratory mixed-methods pilot study using a single-group pre-post design.MethodsThe 7-week intervention was delivered to Black middle school girls participating in a district-based enrichment program in Southern California. Participants who completed both pre- and post-assessments (N = 14) were included in the analyses. Outcomes included body image, self-esteem, physical activity enjoyment, self-compassion, and anxiety/depressive symptoms. Prior to analysis, normality of difference scores was evaluated using the Shapiro-Wilk test. Given observed violations of normality and the small sample size, Wilcoxon signed-rank tests were conducted for all pre-post comparisons. Baseline bivariate correlations were also examined. Qualitative data were collected through three semi-structured focus groups and analyzed using inductive thematic analysis.ResultsBaseline correlations revealed a positive association between body image and self-esteem, and a negative association between self-compassion and anxiety/depressive symptoms. Wilcoxon signed-rank tests indicated no statistically significant pre-to-post changes across outcome variables; however, several outcomes showed small-to-medium effect sizes in the expected direction, including body esteem weight (r = .320), PHQ anxiety (r = .348), and self-compassion self-kindness (r = .359). Qualitative findings identified four themes: body image discussions, perceptions of physical activity, connection, and program recommendations. Participants described increased self-love, confidence, and self-kindness; enjoyment of both strength-based and expressive movement; meaningful peer and coach relationships; and a desire for greater autonomy in programming.ConclusionFindings demonstrate the feasibility and acceptability of a culturally responsive pilot intervention for Black adolescent girls. Larger, controlled studies are needed to evaluate efficacy and inform scalable implementation. FAU - Walters, Kellie AU - Walters K AUID- ORCID: 0000-0002-0892-8028 AD - Department of Kinesiology, California State University Long Beach, Long Beach, CA, USA. RINGGOLD: 14668 FAU - Johnson, Amber AU - Johnson A AD - Department of Health Science, Director for the Center for Health Equity Research, California State University Long Beach, Long Beach, CA, USA. RINGGOLD: 14668 FAU - Pope, Alexis AU - Pope A AD - Public Health, University of California, Berkeley, CA, USA. RINGGOLD: 1438 LA - eng PT - Journal Article DEP - 20260807 PL - United States TA - Womens Health (Lond) JT - Women's health (London, England) JID - 101271249 SB - IM MH - Humans MH - Female MH - *Body Image/psychology MH - Pilot Projects MH - Adolescent MH - *Self Concept MH - *Black or African American/psychology MH - California MH - Exercise/psychology MH - Body Satisfaction MH - Anxiety/psychology MH - Focus Groups MH - Depression/psychology PMC - PMC13451688 OTO - NOTNLM OT - culturally grounded programming OT - health equity OT - physical activity behavior OT - psychosocial wellbeing OT - self-compassion OT - self-esteem OT - self-perception OT - youth health disparities COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/08/08 00:37 MHDA- 2026/08/08 00:38 PMCR- 2026/08/07 CRDT- 2026/08/07 20:03 PHST- 2026/08/08 00:38 [medline] PHST- 2026/08/08 00:37 [pubmed] PHST- 2026/08/07 20:03 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - 10.1177_17455057261476900 [pii] AID - 10.1177/17455057261476900 [doi] PST - ppublish SO - Womens Health (Lond). 2026 Jan-Dec;22:17455057261476900. doi: 10.1177/17455057261476900. Epub 2026 Aug 7. PMID- 42566620 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260813 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 32 DP - 2026 Aug 7 TI - Development and validation of a nomogram prediction model for mild pulmonary arterial hypertension risk in children with left-to-right shunt congenital heart disease. PG - e50136 LID - 10.1097/MD.0000000000050136 [doi] LID - e50136 AB - Mild pulmonary arterial hypertension (PAH) represents an early and potentially reversible complication stage in children with congenital structural heart disease (CHD). Early identification of high-risk children is crucial for improving prognosis. This study aimed to develop and validate a nomogram model for predicting the risk of mild PAH in children with left-to-right shunt CHD. This single-center retrospective study enrolled 340 children diagnosed with CHD who underwent cardiac catheterization at the Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, between January 2005 and April 2022. Patients were divided into a training set (n = 237) and an internal validation set (n = 103) at a 7:3 ratio using stratified random sampling. In the training set, predictors were selected from 35 candidate variables using least absolute shrinkage and selection operator regression combined with 10-fold cross-validation, and the final prediction model was constructed using multivariate logistic regression. Model performance was comprehensively evaluated through Bootstrap internal validation (1000 resampling iterations) and on the independent validation set, including discrimination (area under the curve [AUC]), calibration (calibration curve), and clinical utility (decision curve analysis). The model ultimately identified 5 independent predictive factors: loud P2, decreased exercise tolerance, defect size, left ventricular systolic diameter Z SCORE, and age. The nomogram constructed based on these factors achieved a Bootstrap-corrected AUC of 0.871 (95% confidence interval = 0.824-0.919) in the training set and an AUC of 0.861 (95% confidence interval = 0.769-0.938) in the independent validation set. The calibration curve indicated high consistency between predicted probabilities and actual observed values. Decision curve analysis demonstrated that the model provided clinical net benefit across a wide range of threshold probabilities. This study successfully developed and validated a well-performing nomogram model for predicting the risk of mild PAH in children with left-to-right shunt CHD. This model integrates easily accessible clinical, imaging, and demographic indicators, facilitating the early identification of high-risk children and providing a practical tool for personalized intervention and clinical decision-making. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Qin, Suyuan AU - Qin S AUID- ORCID: 0009-0000-8036-5365 AD - Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Difficult and Critical Illness Center and the Pediatric Clinical Medical Research Center of Guangxi, Nanning, Guangxi, China. FAU - Shang, Lifeng AU - Shang L FAU - Su, Danyan AU - Su D FAU - Ye, Bingbing AU - Ye B FAU - Huang, Yuqin AU - Huang Y FAU - Huang, Yanyun AU - Huang Y FAU - Pang, Yusheng AU - Pang Y LA - eng PT - Journal Article PT - Validation Study PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - *Nomograms MH - *Heart Defects, Congenital/complications MH - Retrospective Studies MH - Female MH - Child MH - Male MH - Child, Preschool MH - *Pulmonary Arterial Hypertension/etiology/diagnosis MH - Cardiac Catheterization MH - Risk Factors MH - Infant MH - Prediction Algorithms MH - *Hypertension, Pulmonary MH - Risk Assessment MH - Prognosis PMC - PMC13456828 OTO - NOTNLM OT - congenital heart disease OT - mild pulmonary arterial hypertension OT - nomogram OT - prediction model OT - risk factors COIS- The authors have no conflicts of interest to declare. EDAT- 2026/08/07 18:36 MHDA- 2026/08/07 18:37 PMCR- 2026/08/07 CRDT- 2026/08/07 14:13 PHST- 2026/01/30 00:00 [received] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/08/07 18:37 [medline] PHST- 2026/08/07 18:36 [pubmed] PHST- 2026/08/07 14:13 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - 00005792-202608070-00066 [pii] AID - MD-D-26-00941 [pii] AID - 10.1097/MD.0000000000050136 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Aug 7;105(32):e50136. doi: 10.1097/MD.0000000000050136. PMID- 42566616 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260813 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 32 DP - 2026 Aug 7 TI - Mid-upper arm circumference and diabetes/prediabetes in children and adolescents: A cross-sectional study using NHANES data. PG - e50083 LID - 10.1097/MD.0000000000050083 [doi] LID - e50083 AB - Mid-upper arm circumference (MUAC) is a simple anthropometric measure proposed as a marker of adiposity and cardiometabolic risk, but its relationship with diabetes and prediabetes in children and adolescents has not been fully characterized. This study assessed the association between MUAC and glycemic status in a nationally representative pediatric sample. We performed a cross-sectional analysis of pooled data from the 1999 to 2018 NHANES cycles, including 27,543 children and adolescents (age 6-19 years), of whom 2165 were classified as having diabetes or prediabetes by standard laboratory and self-report criteria. MUAC was measured at the midpoint of the right upper arm. Survey-weighted logistic regression models evaluated MUAC as both a continuous and categorical (quartiles) predictor of diabetes/prediabetes, adjusting for age, sex, race, education, poverty‑income ratio, body mass index, elevated blood pressure, and dyslipidemia. Restricted cubic spline analysis examined nonlinearity; subgroup analyses tested robustness. Higher MUAC was independently associated with higher odds of diabetes/prediabetes: per 1‑cm increase odds ratio: 1.04 (95% confidence interval [CI]: 1.01-1.08; P = .020). Versus Q1, adjusted odds ratios were Q2 2.57 (95% CI: 1.81-3.67), Q3 2.40 (95% CI: 1.60-3.61), Q4 2.49 (95% CI: 1.57-3.97) (all P < .001). Restricted cubic spline revealed a significant non‑linear association (P‑nonlinearity <.001) with an inflection near MUAC approximately 25.6 cm, above which odds increased more steeply. Subgroup analyses indicated stronger associations in females and in children <14 years. Associations remained consistent across the analyses. In this large, nationally representative sample of children and adolescents, elevated MUAC was independently associated with higher odds of diabetes and prediabetes, with evidence of a nonlinear dose-response and a threshold near 25.6 cm. Prospective studies are needed to validate cutoffs and explore the potential role of MUAC as a risk marker for dysglycemia. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Zhu, Li AU - Zhu L AUID- ORCID: 0009-0003-0595-3038 AD - Department of Pediatrics, Chengde Central Hospital, Chengde, Hebei, China. FAU - Li, He AU - Li H FAU - Li, Tao AU - Li T LA - eng GR - 202406A008/S&T Program of Chengde/ PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Adolescent MH - Female MH - Cross-Sectional Studies MH - *Prediabetic State/epidemiology/diagnosis MH - Child MH - *Arm/anatomy & histology MH - Male MH - Nutrition Surveys MH - *Diabetes Mellitus/epidemiology/diagnosis MH - Young Adult MH - Adiposity MH - Anthropometry/methods MH - Body Mass Index MH - United States/epidemiology PMC - PMC13456841 OTO - NOTNLM OT - children and adolescents OT - cross-sectional analysis OT - diabetes/prediabetes OT - mid‑upper arm circumference COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2026/08/07 18:36 MHDA- 2026/08/07 18:37 PMCR- 2026/08/07 CRDT- 2026/08/07 14:13 PHST- 2025/12/19 00:00 [received] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/08/07 18:37 [medline] PHST- 2026/08/07 18:36 [pubmed] PHST- 2026/08/07 14:13 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - 00005792-202608070-00062 [pii] AID - MD-D-25-18375 [pii] AID - 10.1097/MD.0000000000050083 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Aug 7;105(32):e50083. doi: 10.1097/MD.0000000000050083. PMID- 42566564 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260813 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 32 DP - 2026 Aug 7 TI - Assessing the association of healthy lifestyle indicators (life's simple 7) with bacterial vaginosis in reproductive-age women: A cross-sectional analysis of a nationwide survey. PG - e50069 LID - 10.1097/MD.0000000000050069 [doi] LID - e50069 AB - Bacterial vaginosis (BV) is a prevalent vaginal infection in reproductive-age women, associated with various behavioral and metabolic factors. Life's simple 7 (LS7), a cardiovascular health metric from the American Heart Association, includes smoking, physical activity, diet, body mass index, blood pressure, blood lipids, and blood glucose. This study aimed to explore the link between LS7 scores and BV, offering a perspective on comprehensive risk assessment. This cross-sectional study used data from the National Health and Nutrition Examination Survey 2001-2004, including 1203 women aged 18 to 49 years (382 BV, 821 controls). Accounting for National Health and Nutrition Examination Survey' complex design, we applied fasting weight (WTSAF2YR), strata (SDMVSTRA), and primary sampling unit (SDMVPSU). Weighted logistic regression models (Crude, Model 1, and Model 2) examined the LS7-BV association. Model 1 adjusted for age, race, poverty income ratio, marital status, and education; Model 2 further adjusted for white blood cell, lymphocyte, monocyte counts, and globulin. LS7 was analyzed categorically (<8.5 vs >/= 8.5), with the cutoff determined by receiver operating characteristic curve. We also performed restricted cubic spline analysis, Extreme Gradient Boosting, and subgroup analyses. Weighted baseline analysis showed that the LS7 score in the BV group (8.31 +/- 2.01) was significantly lower than that in the normal group (8.93 +/- 2.02, P < .001). Weighted logistic regression revealed that each 1-unit increase in LS7 was associated with lower BV odds in the Crude Model (odds ratio [OR] = 0.86, 95% confidence interval [CI]: 0.80-0.92, P < .001) and remained significant in Model 2 (OR = 0.90, 95% CI: 0.82-0.98, P = .013). In categorical analysis, LS7 >/= 8.5 was associated with lower BV odds than < 8.5 (Crude OR = 0.60, 95% CI: 0.43-0.85, P = .005). Restricted cubic spline analysis showed a significant inverse dose-response relationship (P for overall = .001). Subgroup and sensitivity analyses confirmed consistent inverse associations and robustness. Higher LS7 scores were associated with lower odds of BV. Due to the cross-sectional design, these findings are associational and cannot establish causality. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Feng, Yang AU - Feng Y AUID- ORCID: 0009-0007-2069-4985 AD - Department of Gynecology, The Affiliated Yongchuan Hospital of Chongqing Medical University, Chongqing, China. FAU - Zhang, Xiaoqian AU - Zhang X AUID- ORCID: 0009-0002-2763-3126 LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Female MH - Humans MH - Cross-Sectional Studies MH - *Vaginosis, Bacterial/epidemiology MH - Adult MH - Adolescent MH - Middle Aged MH - Nutrition Surveys MH - Young Adult MH - *Healthy Lifestyle MH - Body Mass Index MH - United States/epidemiology MH - Risk Assessment MH - Risk Factors MH - Exercise MH - Blood Pressure MH - Diet PMC - PMC13456739 OTO - NOTNLM OT - NHANES OT - bacterial vaginosis (BV) OT - lifestyle factors OT - life's simple 7 (LS7) COIS- The authors have no funding and conflicts of interest to declare. EDAT- 2026/08/07 18:36 MHDA- 2026/08/07 18:37 PMCR- 2026/08/07 CRDT- 2026/08/07 14:12 PHST- 2025/11/26 00:00 [received] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/08/07 18:37 [medline] PHST- 2026/08/07 18:36 [pubmed] PHST- 2026/08/07 14:12 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - 00005792-202608070-00010 [pii] AID - MD-D-25-16838 [pii] AID - 10.1097/MD.0000000000050069 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Aug 7;105(32):e50069. doi: 10.1097/MD.0000000000050069. PMID- 42565990 OWN - NLM STAT- Publisher LR - 20260807 IS - 1432-1971 (Electronic) IS - 0172-0643 (Linking) DP - 2026 Aug 7 TI - Estimating Exercise Intensity Using Heart Rate Methods in Children and Young Adults with Pulmonary Hypertension. LID - 10.1007/s00246-026-04411-z [doi] AB - Standard methods for prescribing exercise intensity in exercise therapy define moderate and vigorous exercise using a percentage of peak heart rate (HR). However, these approaches may be inappropriate for pediatric patients with pulmonary hypertension (PH) due to impaired vasodilatory function, chronotropic incompetence, and because the methods were developed based on adult data. This study aimed to evaluate the accuracy of recommended exercise prescription methods in children and young adults with PH. This retrospective study included patients aged 6-25 years with PH. Accuracy was assessed by comparing HR values for moderate and vigorous exercise zones, defined by traditional methods against a gold standard (GS) derived from cardiac or pulmonary exercise testing using the ventilatory threshold and respiratory compensation threshold. Independent t-tests were used to assess differences between methods, and Bland-Altman plots were used to determine limits of agreement relative to the GS. Data from 134 patients (mean age 17 +/- 4 years) were analyzed. For moderate intensity, HR values generated by all three traditional techniques differed significantly from the GS (all p < 0.001). For vigorous intensity, zones based on percentage of peak VO(2) and percentage of peak HR were significantly different from the GS (p < 0.001), whereas zones based on percentage of HR reserve were not (p = 0.558). Bland-Altman analysis showed poor agreement overall, with most cases falling outside acceptable limits of difference (approximately 50-80% of cases). Recommended exercise prescription methods did not accurately define exercise intensity zones in pediatric and young adult patients with PH. Population-specific approaches may improve exercise prescription accuracy in this group. CI - (c) 2026. The Author(s). FAU - Kwan, Li Ting AU - Kwan LT AD - Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. AD - Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Irving Medical Center - New York Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. FAU - Del Mundo, Ruskin Jake S AU - Del Mundo RJS AD - Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. FAU - McCown, Mary E AU - McCown ME AD - Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Irving Medical Center - New York Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. FAU - Fremed, Michael A AU - Fremed MA AD - Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Irving Medical Center - New York Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. FAU - Krishnan, Usha S AU - Krishnan US AD - Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Irving Medical Center - New York Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. FAU - Liberman, Leonardo AU - Liberman L AD - Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Irving Medical Center - New York Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. FAU - Asiedu, Quinten D AU - Asiedu QD AD - Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Irving Medical Center - New York Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. FAU - Layton, Aimee M AU - Layton AM AUID- ORCID: 0000-0002-5452-2811 AD - Division of Pediatric Cardiology, Department of Pediatrics, Columbia University Irving Medical Center - New York Presbyterian Morgan Stanley Children's Hospital, New York, NY, USA. aml2135@cumc.columbia.edu. AD - Children's Hospital of New York, 7th floor, room 711 3959 Broadway, New York, NY, 10032, USA. aml2135@cumc.columbia.edu. LA - eng PT - Journal Article DEP - 20260807 PL - United States TA - Pediatr Cardiol JT - Pediatric cardiology JID - 8003849 SB - IM OTO - NOTNLM OT - Exercise OT - Exercise prescription OT - Pediatric OT - Pulmonary hypertension OT - Rehabilitation COIS- Declarations. Competing Interests: The authors declare no competing interests. EDAT- 2026/08/07 12:39 MHDA- 2026/08/07 12:39 CRDT- 2026/08/07 11:13 PHST- 2026/03/24 00:00 [received] PHST- 2026/07/25 00:00 [accepted] PHST- 2026/08/07 12:39 [medline] PHST- 2026/08/07 12:39 [pubmed] PHST- 2026/08/07 11:13 [entrez] AID - 10.1007/s00246-026-04411-z [pii] AID - 10.1007/s00246-026-04411-z [doi] PST - aheadofprint SO - Pediatr Cardiol. 2026 Aug 7. doi: 10.1007/s00246-026-04411-z. PMID- 42565127 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260807 LR - 20260813 IS - 0971-9261 (Print) IS - 1998-3891 (Electronic) IS - 0971-9261 (Linking) VI - 31 IP - 4 DP - 2026 Jul-Aug TI - Single-incision Scrotal Orchidopexy in Children: A Clinical Series. PG - 638-642 LID - 10.4103/jiaps.jiaps_21_26 [doi] AB - OBJECTIVE: To evaluate the feasibility, success rate, and outcomes of single-incision scrotal orchiopexy (SISO) for palpable undescended testes using a novel "touch sign" for patient selection. No comparison groups were included. METHODS: A retrospective review of 162 patients (aged 7 months-14 years) treated between 2019 and 2024 was performed. Palpable cases underwent preoperative "touch sign" assessment (balloting the testis from the inguinal canal to the scrotum), followed by transverse scrotal incision, tunica vaginalis mobilization, and dartos pouch placement. RESULTS: Of the 162 patients assessed, 116 underwent SISO (112 successful; 4 conversions due to obesity or tunica vaginalis issues). Follow-up (1 month-5 years) showed no testicular atrophy, and one patient developed a clinical inguinal hernia after more than 3 years of SISO. SISO offers superior cosmesis and shorter operative time/hospital stay than the traditional method. CONCLUSION: SISO is a safe and effective procedure for low-lying palpable testes, with the "touch sign" improving patient selection and minimizing conversions. The first author has described this novel maneuver- the "touch sign" during the clinical examination. CI - Copyright: (c) 2026 Journal of Indian Association of Pediatric Surgeons. FAU - Miglani, Harparkash Singh AU - Miglani HS AD - Child Surgery Centre, Miglani Hospital, Amritsar, Punjab, India. FAU - Sethi, Bijaya Kumar AU - Sethi BK AD - Department of Paediatric Surgery, All India Institute of Medical Sciences, Bilaspur, Himachal Pradesh, India. FAU - Hanspal, Era AU - Hanspal E AD - Resident Doctor Foundation Year 2, Department of General Practice NHS Grampian, Elgin, United Kingdom. LA - eng PT - Journal Article DEP - 20260702 PL - India TA - J Indian Assoc Pediatr Surg JT - Journal of Indian Association of Pediatric Surgeons JID - 101179870 PMC - PMC13446958 OTO - NOTNLM OT - Orchiopexy OT - palpable undescended testes OT - single-incision scrotal orchiopexy OT - testicular mobilization OT - touch sign COIS- There are no conflicts of interest. EDAT- 2026/08/07 12:39 MHDA- 2026/08/07 12:40 PMCR- 2026/07/01 CRDT- 2026/08/07 06:27 PHST- 2026/01/09 00:00 [received] PHST- 2026/02/20 00:00 [revised] PHST- 2026/03/12 00:00 [accepted] PHST- 2026/08/07 12:40 [medline] PHST- 2026/08/07 12:39 [pubmed] PHST- 2026/08/07 06:27 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - JIAPS-31-638 [pii] AID - 10.4103/jiaps.jiaps_21_26 [doi] PST - ppublish SO - J Indian Assoc Pediatr Surg. 2026 Jul-Aug;31(4):638-642. doi: 10.4103/jiaps.jiaps_21_26. Epub 2026 Jul 2. PMID- 42564828 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260807 LR - 20260813 IS - 2574-2531 (Electronic) IS - 2574-2531 (Linking) VI - 9 IP - 4 DP - 2026 Aug TI - Identification of obesity risk factors in 3-12-year-old children and adolescents with prior respiratory tract infections via interpretable machine and deep learning models. PG - ooag061 LID - 10.1093/jamiaopen/ooag061 [doi] LID - ooag061 AB - BACKGROUNDS AND OBJECTIVES: Childhood obesity and respiratory tract infections (RTIs) are 2 major global public health issues that frequently co-occur and are closely interrelated. Early detection of children with prior RTIs who are at high obesity risk is crucial for targeted interventions. This study integrates interpretable machine learning (ML) models and a deep learning network to develop an obesity risk prediction model in a large pediatric cohort. METHODS: Cross-sectional data from 6509 children and adolescents aged 3-12 years with prior RTIs in Beijing and Tangshan were fed to 12 ML models to predict childhood obesity (versus children with normal weight). Bayesian optimization was applied to fine-tune model hyperparameters. Prediction performance was assessed using 8 metrics. Key predictive features were identified by SHapley Additive exPlanations (SHAP). The validity of the optimal ML model was verified by the sequential neural network model. RESULTS: Of 12 ML models, LightGBM achieved the optimal performance (accuracy: 0.8844, area under the curve [AUC]: 0.9491). SHAP analysis identified 20 key predictors, including child age, paternal body mass index (BMI), maternal BMI, birth length, birthweight, gestational age, eating speed, complementary feeding initiation age, screen time, breastfeeding duration, bedtime, maternal age, nighttime sleep, outdoor activity, dental caries, sedentary time, food allergies, family history of diabetes, and sex. The deep learning sequence network model further validated the predictive value of these features (accuracy: 0.8023, AUC: 0.8117), and the SHAP-driven feature importance rankings were in close line with LightGBM. CONCLUSIONS: Our LightGBM-based model enables effective prediction of obesity risk in children aged 3-12 years with prior RTIs, and the key features identified can inform early screening and facilitate personalized interventions. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the American Medical Informatics Association. FAU - Wang, Xiao-Qian AU - Wang XQ AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. FAU - Zheng, Fang-Jie-Yi AU - Zheng FJ AD - Center for Evidence-Based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Wang, Qiong AU - Wang Q AD - Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China. AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing 100029, China. FAU - Li, Che AU - Li C AD - Center for Evidence-Based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Zhang, Wen-Qian AU - Zhang WQ AD - Center for Evidence-Based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Zhang, Zhi-Xin AU - Zhang ZX AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing 100029, China. AD - Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China. FAU - Niu, Wen-Quan AU - Niu WQ AUID- ORCID: 0000-0003-1715-3372 AD - Center for Evidence-Based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. LA - eng SI - Dryad/10.5061/dryad.gf1vhhn44 PT - Journal Article DEP - 20260806 PL - United States TA - JAMIA Open JT - JAMIA open JID - 101730643 PMC - PMC13445979 OTO - NOTNLM OT - Childhood obesity OT - SHapley Additive exPlanations OT - deep learning OT - machine learning OT - respiratory tract infection COIS- The authors declare that there is no conflict of interest regarding the publication of this article. EDAT- 2026/08/07 12:39 MHDA- 2026/08/07 12:40 PMCR- 2026/08/06 CRDT- 2026/08/07 06:08 PHST- 2026/01/05 00:00 [received] PHST- 2026/03/16 00:00 [revised] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/08/07 12:40 [medline] PHST- 2026/08/07 12:39 [pubmed] PHST- 2026/08/07 06:08 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - ooag061 [pii] AID - 10.1093/jamiaopen/ooag061 [doi] PST - epublish SO - JAMIA Open. 2026 Aug 6;9(4):ooag061. doi: 10.1093/jamiaopen/ooag061. eCollection 2026 Aug. PMID- 42564584 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260813 IS - 1729-0503 (Electronic) IS - 1680-6905 (Print) IS - 1680-6905 (Linking) VI - 26 IP - 2 DP - 2026 Jun TI - Diagnostic relevance of osteocalcin and bone alkaline phosphatase as markers of bone turnover in Sickle Cell Anaemia: A Zaria study. PG - 59-68 LID - 10.4314/ahs.v26i2.8 [doi] AB - BACKGROUND: Sickle cell anaemia (SCA) significantly contributes to skeletal morbidity in Nigeria, with bone complications like pain crises and avascular necrosis prevalent. Osteocalcin (OC) and bone-specific alkaline phosphatase (BALP) are potential markers of bone formation, yet their diagnostic utility in SCA is underexplored in African populations. OBJECTIVE: To assess serum OC and BALP levels in Nigerian SCA patients during bone pain crises (BPC), steady state, and in healthy controls, evaluating their diagnostic relevance for bone turnover. METHODS: This cross-sectional study at Ahmadu Bello University Teaching Hospital, Zaria, enrolled 180 adults (60 SCA in BPC, 60 steady state, 60 HbAA controls). Serum OC and BALP were measured via ELISA. Data were analyzed using Kruskal-Wallis tests, Spearman's correlation, and ROC curves (p90%) and the lack of effective GF-food specific health policies ( approximately 94%) were the most commonly cited barriers to GF-FS, particularly in GF-FI households. Social media (>60%) was used to share information related to tax credits (15%) affordability, accessibility, and availability of GF-foods (75%). Parents deemed child tax credits ( approximately 75%), development of food policies focused on education in schools ( approximately 34%), dietary prescriptions (25%) and official recognition of CD as a disability ( approximately 26%) as important to address GF-FI. In conclusion, parents perceive high GF-food costs and lack of effective GF-food health policies as important mediators of GF-FI. Social media platforms were widely used by the community to share information and solutions to address GF-FI. CI - (c) The Author(s) 2026. FAU - Mager, Diana R AU - Mager DR AUID- ORCID: 0000-0002-5558-8783 AD - Department of Agricultural, Food and Nutritional Sciences, Faculty of Agricultural, Food & Environmental Science, University of Alberta, Canada. ROR: https://ror.org/0160cpw27 AD - Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Canada. FAU - Anders, Sven AU - Anders S AD - Department of Resource Economics & Environmental Sociology, Faculty of Agricultural, Life and Environmental Science, University of Alberta, Canada. FAU - Bruce, Marcia AU - Bruce M AD - Faculty of Medicine, University of Calgary, Canada. FAU - Turner, Justine M AU - Turner JM AD - Department of Agricultural, Food and Nutritional Sciences, Faculty of Agricultural, Food & Environmental Science, University of Alberta, Canada. ROR: https://ror.org/0160cpw27 AD - Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Canada. LA - eng PT - Journal Article DEP - 20260730 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 SB - IM MH - Humans MH - *Celiac Disease/diet therapy MH - *Diet, Gluten-Free/economics MH - *Food Insecurity MH - Cross-Sectional Studies MH - Child MH - Female MH - Male MH - *Parents/psychology MH - Surveys and Questionnaires MH - Adult MH - Child, Preschool MH - Family Characteristics MH - Adolescent MH - Health Policy MH - *Food Supply PMC - PMC13439013 OTO - NOTNLM OT - Caregiver perspectives OT - Food insecurity OT - Gluten-free diet OT - Policy OT - social media COIS- The authors declare none. EDAT- 2026/08/06 12:37 MHDA- 2026/08/06 12:38 PMCR- 2026/07/30 CRDT- 2026/08/06 06:48 PHST- 2025/08/13 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/08/06 12:38 [medline] PHST- 2026/08/06 12:37 [pubmed] PHST- 2026/08/06 06:48 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - S2048679026101311 [pii] AID - 10.1017/jns.2026.10131 [doi] PST - epublish SO - J Nutr Sci. 2026 Jul 30;15:e69. doi: 10.1017/jns.2026.10131. eCollection 2026. PMID- 42559005 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260806 LR - 20260813 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Smartwatch and physical education exam stress: the role of exercise self-efficacy and physical self-concept. PG - 1882938 LID - 10.3389/fpsyt.2026.1882938 [doi] LID - 1882938 AB - Against the backdrop of increasing educational digitalization and growing concerns over adolescent physical health, and based on social cognitive theory, this study examines the associations between attitudes toward smartwatch usage and the stress of junior high school students in the High School Entrance Examination Physical Education (PE examination), and further explores its dynamics through the correlational roles of exercise self-efficacy and physical self-concept. Structural Equation Modeling (SEM) analysis reveals that attitudes toward smartwatch use are directly negatively associated with PE examination stress (beta = -0.197) and are also indirectly associated with lower stress through their positive associations with exercise self-efficacy (indirect effect = -0.108) and physical self-concept (indirect effect = -0.172). In addition, decision tree analysis using the CHAID algorithm identifies physical self-concept as the most critical associated predictive variable. Exercise self-efficacy and attitude toward smartwatch use serve as subsequent hierarchical factors. The findings suggest that smartwatch usage is negatively associated with examination stress by providing objective data feedback and functioning as a "digital mirror", which is associated with boosting students' confidence in exercise and body awareness. The results offer empirical evidence for the application of smart technology in school physical education and propose a "data-driven" correlational framework for understanding adolescents' physical examination stress. Future research could incorporate longitudinal designs and cross-cultural comparisons to further validate the educational relevance of smartwatches, and should also examine potential negative effects such as data-driven anxiety or social comparison. CI - Copyright (c) 2026 Liu, Yang, Cui, Chen and Shi. FAU - Liu, Qi AU - Liu Q AD - School of Teacher Development, Shaanxi Normal University, Xi'an, China. FAU - Yang, Hongli AU - Yang H AD - College of Education for the Future, Beijing Normal University, Zhuhai, China. FAU - Cui, Qi AU - Cui Q AD - School of Education, Shanghai Jiao Tong University, Shanghai, China. FAU - Chen, Jihe AU - Chen J AD - The Faculty of Education, Southwest University, Chongqing, China. FAU - Shi, Bing AU - Shi B AD - Physical Education School, Shaanxi Normal University, Xi'an, China. LA - eng PT - Journal Article DEP - 20260722 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13438291 OTO - NOTNLM OT - adolescent health OT - artificial intelligence OT - exercise self-efficacy OT - physical self-concept OT - smartwatch COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/06 12:37 MHDA- 2026/08/06 12:38 PMCR- 2026/07/22 CRDT- 2026/08/06 06:46 PHST- 2026/05/16 00:00 [received] PHST- 2026/06/05 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/08/06 12:38 [medline] PHST- 2026/08/06 12:37 [pubmed] PHST- 2026/08/06 06:46 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1882938 [doi] PST - epublish SO - Front Psychiatry. 2026 Jul 22;17:1882938. doi: 10.3389/fpsyt.2026.1882938. eCollection 2026. PMID- 42558837 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Design and content validation of AUTIVA: an ecobiopsychosocial instrument for childhood autism. PG - 1768438 LID - 10.3389/fpubh.2026.1768438 [doi] LID - 1768438 AB - There are no community-based surveys for the development or assessment of public policies with an ecobiopsychosocial approach for autistic children. This article reports the development of an instrument assessing characteristics of Chilean autistic children, in order to understand how autism manifests in different environments. This study consisted of two stages: Firstly, after a comprehensive literature review, an instrument was designed by health and education professionals alongside autistic individuals and primary caregivers. Secondly, content validation was performed using the Content Validity Index, through the calculation of the Lawshe Content Validity Ratio. Sixty questions were validated, distributed across six subscales: "General Health Profile" obtained a Content Validity of 0.94; The subscales "Sex and Gender," "Autism Diagnosis and Concomitant Pathologies," "Family Income and the Impact of Autism on Socioeconomic Status," "Diet of the Autistic Person," and "Therapies and Schooling" obtained Content Validity Indexes of 0.89; 0.98; 1.0; 0.96; and 1.0, respectively. The Content Validity Index for the full instrument was 0.96. The survey presented demonstrated initial evidence of content validity and may serve as a basis for future psychometric validation. It allows for the assessment of this population in various life aspects, and offers great potential for creating public care policies regarding this community. As this study represents an initial content validation phase, future research should assess construct validity, criterion-related validity, reliability, and cross-cultural applicability. CI - Copyright (c) 2026 Castillo-Ortega, Hewstone-Garcia, Belmar-Riquelme and Jara-Mella. FAU - Castillo-Ortega, Ruben AU - Castillo-Ortega R AD - Facultad de Cs. Para la Rehabilitacion y Calidad de Vida, Universidad San Sebastian, Sede Valdivia, Chile. AD - Vicerrectoria de Vinculacion con el Medio, Universidad San Sebastian, Sede Valdivia, Chile. FAU - Hewstone-Garcia, Carol AU - Hewstone-Garcia C AD - Facultad de Educacion, Universidad San Sebastian, Sede Valdivia, Chile. FAU - Belmar-Riquelme, Gladys AU - Belmar-Riquelme G AD - Facultad de Cs. Para la Rehabilitacion y Calidad de Vida, Universidad San Sebastian, Sede Valdivia, Chile. FAU - Jara-Mella, Vannia AU - Jara-Mella V AD - Facultad de Cs. Para la Rehabilitacion y Calidad de Vida, Universidad San Sebastian, Sede Valdivia, Chile. LA - eng PT - Journal Article PT - Validation Study DEP - 20260722 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Autistic Disorder/diagnosis/psychology MH - Child MH - Female MH - Male MH - Chile MH - Surveys and Questionnaires/standards MH - Psychometrics MH - Reproducibility of Results MH - Child, Preschool PMC - PMC13438446 OTO - NOTNLM OT - Latin America OT - autism spectrum disorder OT - autistic disorder OT - biopsychosocial models OT - content validity OT - health equity OT - health planning OT - public health surveillance COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/06 12:37 MHDA- 2026/08/06 12:38 PMCR- 2026/07/22 CRDT- 2026/08/06 06:30 PHST- 2025/12/15 00:00 [received] PHST- 2026/05/08 00:00 [revised] PHST- 2026/07/03 00:00 [accepted] PHST- 2026/08/06 12:38 [medline] PHST- 2026/08/06 12:37 [pubmed] PHST- 2026/08/06 06:30 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1768438 [doi] PST - epublish SO - Front Public Health. 2026 Jul 22;14:1768438. doi: 10.3389/fpubh.2026.1768438. eCollection 2026. PMID- 42558385 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Association between inflammatory indicators derived from preconception complete blood count and specific adverse fetal, neonatal, and pregnancy outcomes: a national cohort study. PG - 1886578 LID - 10.3389/fendo.2026.1886578 [doi] LID - 1886578 AB - BACKGROUND: Adverse fetal and neonatal outcomes, including small for gestational age (SGA), large for gestational age (LGA), and low birth weight (LBW), seriously endanger maternal and infant health. Currently, the associations between preconception baseline immune-inflammatory status and the above specific adverse pregnancy outcomes still lack systematic population-based cohort evidence. METHODS: Based on the National Free Preconception Health Examination Program in China from 2010 to 2012, this large-sample cohort study recruited rural women of childbearing age in China. Multivariate logistic regression and restricted cubic spline (RCS) models were used to systematically analyze the associations between preconception complete blood count (CBC)-derived inflammatory indicators, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), systemic immune-inflammation index (SII), and adverse fetal, neonatal, and pregnancy outcomes. RESULTS: A total of 49,855 preconception participants were enrolled in this study, among whom 16,105 cases experienced adverse fetal and neonatal outcomes. Quartile analysis revealed distinct outcome-specific associations of inflammatory indicators. Moderate levels of NLR increased the risk of SGA, while moderate NLR and SII levels reduced the risk of LGA; the highest quartile of PLR elevated the risk of LGA, and moderate NLR decreased the risk of preterm birth. Only high levels of NLR exerted a protective effect against HBW. Further RCS analyses confirmed significant U-shaped nonlinear associations of NLR, PLR, and SII with LGA, as well as U-shaped correlations of PLR and SII with preterm birth, indicating obvious threshold effects of preconception inflammation on pregnancy outcomes. CONCLUSION: After adjusting available covariates, preconception NLR, PLR, and SII exhibited outcome-specific threshold associations with adverse fetal and neonatal outcomes, yet unmeasured confounders (preconception infection, maternal nutrition, etc.) may overestimate these correlations. Owing to the large sample, many significant results carry modest effect sizes with limited individual clinical utility; these markers merely offer population-based epidemiological references instead of standalone screening indicators for rural preconception risk stratification. Our results require validation in modern urban and multicenter cohorts due to the historical rural-only study population. CI - Copyright (c) 2026 Jiang, Song, Du, Zhang, Chen and Pan. FAU - Jiang, Yue AU - Jiang Y AD - Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Translational Medicine Center, State Key Laboratory of Complex Severe and Rare Diseases, National Health Commission Key Laboratory of Endocrinology, Beijing, China. FAU - Song, Shuaihua AU - Song S AD - Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Translational Medicine Center, State Key Laboratory of Complex Severe and Rare Diseases, National Health Commission Key Laboratory of Endocrinology, Beijing, China. FAU - Du, Hanze AU - Du H AD - Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Translational Medicine Center, State Key Laboratory of Complex Severe and Rare Diseases, National Health Commission Key Laboratory of Endocrinology, Beijing, China. FAU - Zhang, Liyuan AU - Zhang L AD - Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Translational Medicine Center, State Key Laboratory of Complex Severe and Rare Diseases, National Health Commission Key Laboratory of Endocrinology, Beijing, China. FAU - Chen, Shi AU - Chen S AD - Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Translational Medicine Center, State Key Laboratory of Complex Severe and Rare Diseases, National Health Commission Key Laboratory of Endocrinology, Beijing, China. FAU - Pan, Hui AU - Pan H AD - Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Translational Medicine Center, State Key Laboratory of Complex Severe and Rare Diseases, National Health Commission Key Laboratory of Endocrinology, Beijing, China. LA - eng PT - Journal Article DEP - 20260722 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Pregnancy Outcome/epidemiology MH - Adult MH - Infant, Newborn MH - *Inflammation/blood/epidemiology MH - Infant, Large for Gestational Age MH - China/epidemiology MH - Cohort Studies MH - Blood Cell Count MH - Infant, Small for Gestational Age MH - Young Adult MH - *Biomarkers/blood MH - *Pregnancy Complications/blood/epidemiology MH - Infant, Low Birth Weight PMC - PMC13437505 OTO - NOTNLM OT - complete blood count OT - inflammatory indicators OT - preconception inflammation OT - pregnancy complications OT - specific adverse pregnancy outcomes COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/06 11:36 MHDA- 2026/08/06 11:37 PMCR- 2026/07/22 CRDT- 2026/08/06 05:42 PHST- 2026/05/20 00:00 [received] PHST- 2026/06/22 00:00 [revised] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/08/06 11:37 [medline] PHST- 2026/08/06 11:36 [pubmed] PHST- 2026/08/06 05:42 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - 10.3389/fendo.2026.1886578 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Jul 22;17:1886578. doi: 10.3389/fendo.2026.1886578. eCollection 2026. PMID- 42558339 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260806 LR - 20260813 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Global trends and emerging themes in youth physical literacy research: a bibliometric analysis (2000-2025). PG - 1859748 LID - 10.3389/fspor.2026.1859748 [doi] LID - 1859748 AB - BACKGROUND: Physical literacy (PL) has emerged as an important framework for understanding children's and adolescents' motivation, confidence, physical competence, knowledge, and engagement in lifelong physical activity. Although youth physical literacy research has expanded rapidly, limited bibliometric evidence has systematically mapped its global development, intellectual structure, and emerging thematic trends. This study aimed to examine the evolution of youth physical literacy research from 2000 to 2025 and identify major research themes, collaboration patterns, and emerging directions. MATERIALS AND METHODS: A bibliometric analysis was conducted using records retrieved from the Web of Science Core Collection and Scopus databases within a multi-database validation framework. After data cleaning, deduplication, and exclusion of records outside the study period, 856 publications published between 2000 and 2025 were included. Bibliometrix, VOSviewer, and CiteSpace were used to examine publication trends, collaboration networks, influential contributors, keyword co-occurrence patterns, thematic clusters, timeline evolution, and burst keywords. RESULTS: Youth physical literacy research showed a sustained increase in publications, particularly after 2015. Canada, Australia, China, the United States, and the United Kingdom were among the most productive countries. Keyword and cluster analyses identified major themes related to physical education, motor competence, physical activity, physical competence, assessment and validation, fitness, health literacy, and public health. Timeline and burst analyses further suggested increasing attention to psychological, educational, and well-being-related themes within the youth physical literacy literature. Cross-database comparison showed consistent patterns in publication trends, leading contributors, and core thematic structures, supporting the robustness of the identified research patterns. CONCLUSION: This study provides a systematic and validated mapping of the global research landscape of youth physical literacy from 2000 to 2025. The findings suggest that youth physical literacy research has expanded from physical education, motor competence, and assessment-oriented topics toward broader educational, psychosocial, and health-related themes. These results offer a knowledge map for researchers, educators, and policymakers interested in advancing youth physical literacy in educational contexts and supporting holistic student development. CI - (c) 2026 Zishan and Mohd Hashim. FAU - Zishan, Zhao AU - Zishan Z AD - Faculty of Educational Sciences and Technology, Universiti Teknologi Malaysia, Johor Bahru, Malaysia. FAU - Mohd Hashim, Asha Hasnimy AU - Mohd Hashim AH AD - Faculty of Educational Sciences and Technology, Universiti Teknologi Malaysia, Johor Bahru, Malaysia. LA - eng PT - Journal Article DEP - 20260722 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13437538 OTO - NOTNLM OT - bibliometric analysis OT - motor competence OT - physical activity OT - physical education OT - physical literacy OT - science mapping OT - youth COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/06 11:36 MHDA- 2026/08/06 11:37 PMCR- 2026/07/22 CRDT- 2026/08/06 05:39 PHST- 2026/04/19 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/03 00:00 [accepted] PHST- 2026/08/06 11:37 [medline] PHST- 2026/08/06 11:36 [pubmed] PHST- 2026/08/06 05:39 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - 10.3389/fspor.2026.1859748 [doi] PST - epublish SO - Front Sports Act Living. 2026 Jul 22;8:1859748. doi: 10.3389/fspor.2026.1859748. eCollection 2026. PMID- 42558337 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Optimal cutoff values of alanine aminotransferase and its derived markers for pediatric MASLD. PG - 1808797 LID - 10.3389/fendo.2026.1808797 [doi] LID - 1808797 AB - BACKGROUND: The early detection of metabolic dysfunction-associated steatotic liver disease (MASLD) is essential. This study aims to evaluate the diagnostic utility and optimal cutoffs of alanine aminotransferase (ALT) and its derived markers, including the ALT/aspartate aminotransferase (AST) and ALT/high-density lipoprotein cholesterol (HDL) ratios, for predicting pediatric MASLD. METHODS: We analyzed data from 1,158 adolescents in the National Health and Nutritional Examination Survey (NHANES) and 263 adolescents from a real-world clinical cohort. MASLD was assessed using vibration-controlled transient elastography in the NHANES cohort and abdominal ultrasonography in the clinical cohort. Logistic regression and receiver operating characteristic (ROC) curve analyses were conducted to evaluate associations and predictive performance. RESULTS: ALT, ALT/AST, and ALT/HDL were significantly associated with MASLD in both datasets, even after adjusting for age and sex (all p < 0.001). In the NHANES cohort, the areas under the ROC curves (AUCs) for ALT, ALT/AST, and ALT/HDL were 0.73, 0.77, and 0.76, respectively, with optimal cutoff values of >14.50 for ALT, >0.74 for ALT/AST, and >0.29 for ALT/HDL in the total population. In the real-world clinical cohort, the corresponding AUCs were 0.84, 0.84, and 0.86, respectively. ALT/HDL demonstrated the highest AUC in both datasets, reaching 0.92 in females in the clinical cohort. CONCLUSIONS: ALT and ALT-derived markers are valuable for predicting pediatric MASLD. Among them, the ALT/HDL ratio demonstrated the best predictive performance, indicating that composite indices integrating markers of hepatic injury and metabolic status may enhance early detection of MASLD in children and adolescents. CI - Copyright (c) 2026 Kim, Lee, Lee, Youn, Baik, Shin, Kwon, Lee, Chae and Song. FAU - Kim, Joon Young AU - Kim JY AD - Gangnam Severance Hospital, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Lee, Eunju AU - Lee E AD - Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Lee, Hye Sun AU - Lee HS AD - Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Youn, Young Hoon AU - Youn YH AD - Gangnam Severance Hospital, Health Promotion Center, Healthcare Research Team, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Baik, Su Jung AU - Baik SJ AD - Gangnam Severance Hospital, Health Promotion Center, Healthcare Research Team, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Shin, Hyun Joo AU - Shin HJ AD - Yongin Severance Hospital, Research Institute of Radiological Science and Center for Clinical Imaging Data Science, Department of Radiology, Yonsei University College of Medicine, Yongin-si, Republic of Korea. FAU - Kwon, Yu-Jin AU - Kwon YJ AD - Yongin Severance Hospital, Department of Family Medicine, Yonsei University College of Medicine, Yongin-si, Republic of Korea. FAU - Lee, Eun Byoul AU - Lee EB AD - Yongin Severance Hospital, Department of Pediatrics, Yonsei University College of Medicine, Yongin-si, Republic of Korea. FAU - Chae, Hyun Wook AU - Chae HW AD - Gangnam Severance Hospital, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea. FAU - Song, Kyungchul AU - Song K AD - Gangnam Severance Hospital, Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea. LA - eng PT - Journal Article DEP - 20260722 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - EC 2.6.1.2 (Alanine Transaminase) RN - 0 (Biomarkers) RN - EC 2.6.1.1 (Aspartate Aminotransferases) SB - IM MH - Humans MH - Female MH - *Alanine Transaminase/blood MH - Male MH - *Biomarkers/blood MH - Adolescent MH - Child MH - ROC Curve MH - Nutrition Surveys MH - *Fatty Liver/diagnosis/blood MH - Aspartate Aminotransferases/blood PMC - PMC13437452 OTO - NOTNLM OT - adolescent OT - biomarkers OT - child OT - early diagnosis OT - fatty liver OT - liver function tests COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/06 11:36 MHDA- 2026/08/06 11:37 PMCR- 2026/07/22 CRDT- 2026/08/06 05:39 PHST- 2026/02/11 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/08/06 11:37 [medline] PHST- 2026/08/06 11:36 [pubmed] PHST- 2026/08/06 05:39 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - 10.3389/fendo.2026.1808797 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Jul 22;17:1808797. doi: 10.3389/fendo.2026.1808797. eCollection 2026. PMID- 42557588 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 1750-1172 (Electronic) IS - 1750-1172 (Linking) VI - 21 IP - 1 DP - 2026 Aug 6 TI - Assessment of cardiometabolic risk using single point insulin sensitivity estimator (SPISE) in pediatric Bardet-Biedl Syndrome: a pilot study. LID - 10.1186/s13023-026-04353-y [doi] LID - 266 AB - BACKGROUND: Bardet-Biedl syndrome (BBS) carries early cardiometabolic risk, yet pediatric screening is complicated by growth and puberty. The metabolic syndrome (MetS) z-score provides a continuous benchmark for clustered risk. The single-point insulin sensitivity estimator (SPISE), based on body mass index (BMI) and fasting lipids, may offer a practical alternative where insulin testing is impractical. We aimed to assess the association between SPISE and cardiometabolic burden in children with molecularly confirmed BBS, and to compare its ability to identify MetS against the MetS z-score benchmark and insulin-derived indices. METHODS: Single-center retrospective pilot study including children/adolescents with genetically confirmed BBS who underwent standardized anthropometry and metabolic profiling (fasting lipids, glucose, insulin; OGTT when available). SPISE-MetS z-score associations were examined using Spearman and adjusted analyses. In adolescents (>/= 10 years), MetS discrimination was evaluated with ROC curves for SPISE, TG/HDL, and homeostatic model assessment for insulin resistance (HOMA-IR), with pairwise DeLong comparisons and Youden-optimal thresholds. RESULTS: Fourteen participants (7 females, 7 males) were evaluated. Median age at last visit was 11.7 years [IQR 7.6-15.5]; BMI SDS was 3.05 [2.47-3.57]. The median MetS z-score was 1.60 [0.90-1.75]. SPISE correlated inversely with the MetS z-score (rho=-0.57, p = 0.021), and adjusted models (age, sex, BMI-SDS) retained significance. Among adolescents (n = 10), SPISE showed the highest AUC for MetS (AUC 0.95; 95% CI 0.82-1.00) versus TG/HDL (AUC 0.81) and HOMA-IR (AUC 0.60); pairwise differences were not statistically significant. Youden-optimal SPISE 0.05). Stroke index and swimming speed (real and synthetic) showed moderate to very strong associations with 1500 m time in both male (r = -0.53 to -0.76) and female swimmers (r = -0.54 to -0.97). In the male model, performance is primarily driven by variables related to stroke efficiency, maximal oxygen uptake, and high-intensity physiological strain. The female model places greater emphasis on pacing-related variables, including mean swimming speed during endurance and [La(-)] tolerance tests, anaerobic threshold velocity, and metabolic stress indicators. Symbolic regression applied to synthetic datasets is suitable to address the small sample size limitations often present in human research, particularly swimming. Coaches and researchers are encouraged to use symbolic regression and synthetic data and to report the resulting equations to support mechanistic interpretation of 1500 m performance prediction equations for male and female swimmers. FAU - Chainok, Phornpot AU - Chainok P AUID- ORCID: 0000-0003-2605-4181 AD - Faculty of Sport Science, Burapha University, Thailand. FAU - Matjiur, Radomyos AU - Matjiur R AUID- ORCID: 0009-0000-9835-6192 AD - Faculty of Sport Science, Burapha University, Thailand. FAU - de Jesus, Karla AU - de Jesus K AUID- ORCID: 0000-0002-7710-9843 AD - Human Performance Laboratory, Faculty of Physical Education and Physiotherapy, Federal University of Amazonas, Brazil. FAU - Dos Santos Coelho, Leandro AU - Dos Santos Coelho L AUID- ORCID: 0000-0001-5728-943X AD - Department of Electrical Engineering, Federal University of Parana, Parana, Brazil. FAU - Cocco Mariani, Viviana AU - Cocco Mariani V AUID- ORCID: 0000-0003-2490-4568 AD - Department of Electrical Engineering, Federal University of Parana, Parana, Brazil. AD - Mechanical Engineering Graduate Program, Federal University of Parana, Parana, Brazil. FAU - Zacca, Rodrigo AU - Zacca R AUID- ORCID: 0000-0003-0494-0000 AD - Research Center in Physical Activity, Health and Leisure (CIAFEL), Faculty of Sport, University of Porto (FADEUP), Porto, Portugal. AD - Laboratory for Integrative and Translational Research in Population Health (ITR), Porto, Portugal. AD - Nucleus of Research in Human Motricity Sciences, Universidad Adventista de Chile, Chillan, Chile. AD - Laboratory of Sport Physiology, Faculty of Sports, University of Porto, Porto, Portugal. FAU - Fernandes, Ricardo J AU - Fernandes RJ AUID- ORCID: 0000-0002-5811-0443 AD - Centre for Research, Education, Innovation and Intervention in Sport (CIFI2D), Faculty of Sport (FADEUP), University of Porto, Porto, Portugal. AD - Porto Biomechanics Laboratory (LABIOMEP), University of Porto, Porto, Portugal. FAU - Vilas-Boas, Joao Paulo AU - Vilas-Boas JP AUID- ORCID: 0000-0002-4109-2939 AD - Centre for Research, Education, Innovation and Intervention in Sport (CIFI2D), Faculty of Sport (FADEUP), University of Porto, Porto, Portugal. AD - Porto Biomechanics Laboratory (LABIOMEP), University of Porto, Porto, Portugal. LA - eng PT - Journal Article DEP - 20260805 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 SB - IM MH - Humans MH - *Swimming/physiology MH - Female MH - *Athletic Performance/physiology MH - Male MH - Biomechanical Phenomena MH - Oxygen Consumption/physiology MH - Adolescent MH - Body Composition MH - Regression Analysis MH - Physical Endurance/physiology MH - Anaerobic Threshold/physiology MH - Anthropometry MH - Stress, Physiological OTO - NOTNLM OT - Biomechanics OT - Exercise physiology OT - Interpretable machine learning OT - Long-Distance Events OT - Sports analytics OT - Swimming OT - Symbolic learning OT - interpretability OT - modelling EDAT- 2026/08/05 13:37 MHDA- 2026/08/28 11:49 CRDT- 2026/08/05 08:13 PHST- 2026/08/28 11:49 [medline] PHST- 2026/08/05 13:37 [pubmed] PHST- 2026/08/05 08:13 [entrez] AID - 10.1080/02640414.2026.2710467 [doi] PST - ppublish SO - J Sports Sci. 2026 Aug;44(16):2065-2082. doi: 10.1080/02640414.2026.2710467. Epub 2026 Aug 5. PMID- 42554309 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261015 IS - 1440-1754 (Electronic) IS - 1034-4810 (Linking) VI - 62 IP - 10 DP - 2026 Oct TI - The Performance of the STRONGkids Nutrition Screening Tool Following Nurse Training in a Tertiary Care Setting. PG - 1894-1900 LID - 10.1111/jpc.70515 [doi] AB - AIM: The low sensitivity of STRONGkids, a nutrition risk screening tool, was observed during its implementation in patient care services at a tertiary care hospital. The screening process improvement was performed to enhance its effectiveness. This study aimed to evaluate the validity and inter-rater reliability of the screening tool after the improvement process. METHODS: This was a cross-sectional study that collected baseline characteristics and clinical data from medical records. STRONGkids score and risk classification were recorded by ward nurses. Concurrent validity was assessed with respect to nutritional status, including undernutrition (BMI Z-score < -2), stunting (height-for-age Z-score < -2), and overall malnutrition (including both undernutrition and stunting). Nutrition risk screening was repeated by a nutrition nurse to determine inter-rater reliability. RESULTS: The study enrolled 1419 paediatric admissions. Undernutrition, stunting, and overall malnutrition were observed in 13%, 17%, and 27.6% of participants, respectively. STRONGkids classified 24%, 71.1%, and 4.9% of patients as having low, moderate, and high nutrition risk, respectively. Patients with high nutrition risk had significantly longer hospital stays and higher rates of hospital-acquired infections. STRONGkids demonstrated sensitivities of 82.4%-82.6% and specificities of 25%-26.5% for nutrition status. Inter-rater reliability was assessed across 320 admissions and showed excellent reliability for both the total score (k = 0.84; p < 0.001) and risk categories (k = 0.89; p < 0.001). CONCLUSION: The performance of the nutrition risk screening tool may differ from that observed in research settings when used in routine clinical practice. STRONGkids demonstrates satisfactory validity and inter-rater reliability after the improvement process. CI - (c) 2026 Paediatrics and Child Health Division (The Royal Australasian College of Physicians). FAU - Ngamboriruk, Punthita AU - Ngamboriruk P AD - Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. FAU - Dumrongwongsiri, Oraporn AU - Dumrongwongsiri O AD - Division of Nutrition, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. FAU - Phoonlapdacha, Phanphen AU - Phoonlapdacha P AD - Division of Nutrition, Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. LA - eng PT - Journal Article DEP - 20260805 PL - Australia TA - J Paediatr Child Health JT - Journal of paediatrics and child health JID - 9005421 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Nutrition Assessment MH - Reproducibility of Results MH - Female MH - Tertiary Care Centers MH - *Mass Screening/methods MH - Male MH - *Malnutrition/diagnosis MH - Child, Preschool MH - Nutritional Status MH - Infant MH - Sensitivity and Specificity MH - *Child Nutrition Disorders/diagnosis OTO - NOTNLM OT - STRONGkids OT - hospitalised children OT - malnutrition OT - nutritional screening EDAT- 2026/08/05 13:37 MHDA- 2026/10/15 23:30 CRDT- 2026/08/05 07:53 PHST- 2026/06/28 00:00 [revised] PHST- 2026/04/28 00:00 [received] PHST- 2026/07/17 00:00 [accepted] PHST- 2026/10/15 23:30 [medline] PHST- 2026/08/05 13:37 [pubmed] PHST- 2026/08/05 07:53 [entrez] AID - 10.1111/jpc.70515 [doi] PST - ppublish SO - J Paediatr Child Health. 2026 Oct;62(10):1894-1900. doi: 10.1111/jpc.70515. Epub 2026 Aug 5. PMID- 42553825 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260805 LR - 20260813 IS - 0973-6131 (Print) IS - 2231-2714 (Electronic) IS - 0973-6131 (Linking) VI - 19 IP - 2 DP - 2026 May-Aug TI - Effect of Adjuvant Yoga Therapy for Chronic Respiratory Diseases in Pediatric Population - A Scoping Review. PG - 128-138 LID - 10.4103/ijoy.ijoy_147_25 [doi] AB - Chronic respiratory diseases (CRD), i.e., asthma, COPD, allergic rhinitis, and tuberculosis, account for approximately one-third of emergency hospitalizations. As a holistic therapy, yoga has the potential to improve both the physical and psychological well-being of individuals with CRD, and its popularity has expanded globally. However, studies assessing yoga's effects have yielded inconsistent results. The scoping review adhered to the PRISMA Extension for scoping reviews, PRISMA-ScR. A protocol was registered on OSF (10.17605/OSF.IO/Q6CKN). We conducted a systematic search on PubMed, Embase, and Scopus, covering studies from inception till december-2024. Inclusion criteria were a pediatric population with CRD, yoga as adjuvant therapy, and English language publications. Data were extracted systematically and categorized based on publication year, author, type of study, country, disease, and intervention. We included 552 database results with 2357 patients, published between 1985 and 2023. Most studies were primarily from India (n = 15), focused on asthma, along with two studies on cystic fibrosis and one each on pleural effusion and bronchiectasis. Study types included observational studies (n = 10), randomized controlled trials (n = 8), controlled trials (n = 1), quasi-experimental studies (n = 1), and pilot studies (n = 2). Yoga improved pulmonary function test scores in asthma, pleural effusion, and bronchiectasis, enhancing quality of life (QOL) and psychological well-being. However, no studies were found on COPD, pneumonia, and tuberculosis in the pediatric population. Quality evidence suggests that yoga improves asthma symptoms and QOL. However, variations in yoga modules limit generalizability. Future research should develop validated disease-specific modules, including unexplored facets like Yama, Niyama, yogic counseling, and diet. Mechanistic studies with long follow-up periods are needed. CI - Copyright: (c) 2026 International Journal of Yoga. FAU - Mahendru, Monica AU - Mahendru M AD - Department of Pediatrics, AIIMS, Rishikesh, Uttarakhand, India. FAU - Mohanty, Sriloy AU - Mohanty S AD - Department of Ayush, AIIMS, Rishikesh, Uttarakhand, India. FAU - Dabas, Dheeraj AU - Dabas D AD - Department of Telemedicine and Biomedical Informatics, AIIMS, Rishikesh, Uttarakhand, India. FAU - Malik, Vivek Singh AU - Malik VS AD - Department of Evidence Synthesis, AIIMS, Rishikesh, Uttarakhand, India. AD - Department of Telemedicine and Biomedical Informatics, AIIMS, Rishikesh, Uttarakhand, India. AD - Cochrane Evidence Synthesis Unit, AIIMS, Rishikesh, Uttarakhand, India. FAU - Singh, Meenu AU - Singh M AD - Department of Evidence Synthesis, AIIMS, Rishikesh, Uttarakhand, India. AD - Department of Telemedicine and Biomedical Informatics, AIIMS, Rishikesh, Uttarakhand, India. AD - Cochrane Evidence Synthesis Unit, AIIMS, Rishikesh, Uttarakhand, India. LA - eng PT - Journal Article PT - Review DEP - 20260625 PL - India TA - Int J Yoga JT - International journal of yoga JID - 101313247 PMC - PMC13436610 OTO - NOTNLM OT - Asthma OT - Yoga OT - cystic fibrosis OT - pulmonary function test COIS- There are no conflicts of interest. EDAT- 2026/08/05 06:41 MHDA- 2026/08/05 06:42 PMCR- 2026/05/01 CRDT- 2026/08/05 05:49 PHST- 2025/06/04 00:00 [received] PHST- 2025/11/05 00:00 [revised] PHST- 2025/11/12 00:00 [accepted] PHST- 2026/08/05 06:42 [medline] PHST- 2026/08/05 06:41 [pubmed] PHST- 2026/08/05 05:49 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - IJY-19-128 [pii] AID - 10.4103/ijoy.ijoy_147_25 [doi] PST - ppublish SO - Int J Yoga. 2026 May-Aug;19(2):128-138. doi: 10.4103/ijoy.ijoy_147_25. Epub 2026 Jun 25. PMID- 42553270 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260805 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Integrating telemedicine into nutritional management of infants with inherited metabolic disorders: a pilot study. PG - 1869508 LID - 10.3389/fped.2026.1869508 [doi] LID - 1869508 AB - BACKGROUND: Several inherited metabolic disorders (IMDs) require intensive and continuous nutritional management, particularly during the first year of life. Telemedicine (TM) may support care delivery in this setting, but evidence in infants remains limited. OBJECTIVE: The aim of this pilot study was to assess the feasibility and acceptability of integrating TM into routine nutritional management of infants with IMDs identified through newborn screening. METHODS: Caregivers of infants with IMDs requiring nutritional management were asked to choose between telemedicine-integrated follow-up (TM group) or exclusively in-person care (NO-TM group). Anthropometric parameters and clinical signs of malnutrition were assessed at birth, 6, and 12 months of life. All measured disease-specific biomarkers were collected. Caregivers assigned to the TM group completed structured questionnaires evaluating TM satisfaction and patients' quality of life. RESULTS: Nine infants with confirmed IMDs were enrolled and followed for 12 months. Seven patients (78%) were managed with TM integration. Growth trajectories and metabolic outcomes remained within expected clinical targets in both groups, and no clinical signs of malnutrition were observed in any patient. Disease-specific biomarkers in patients with phenylketonuria and citrullinemia type I remained within target ranges in both groups, with more stable phenylalanine levels observed in patients in the TM group. Caregivers reported high satisfaction with TM (median score: 94.5% of the maximum possible score). Quality of life scores were high in all patients. CONCLUSIONS: In this small pilot cohort, partial integration of TM into nutritional management of infants with IMDs appeared feasible, was well accepted by caregivers, and was not affected by evident adverse effects on growth or metabolic control during the first year of life. Larger studies are needed to confirm these observations and support wider implementation. CI - (c) 2026 Tagi, Montanari, Tosi, Stucchi, Cartalemi, Gandini, Eletti, Perico, Borsani, Fiori, Calcaterra and Zuccotti. FAU - Tagi, Veronica Maria AU - Tagi VM AD - Metabolic Diseases Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. FAU - Montanari, Chiara AU - Montanari C AD - Metabolic Diseases Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. FAU - Tosi, Martina AU - Tosi M AD - Metabolic Diseases Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. AD - Department of Health Sciences, University of Milan, Milan, Italy. FAU - Stucchi, Eliana AU - Stucchi E AD - Pediatric Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Cartalemi, Aurora Maria Esmeralda AU - Cartalemi AME AD - Pediatric Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Gandini, Letizia AU - Gandini L AD - Pediatric Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Eletti, Francesca AU - Eletti F AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. AD - Pediatric Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Perico, Veronica AU - Perico V AD - Metabolic Diseases Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. FAU - Borsani, Barbara AU - Borsani B AD - Pediatric Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Fiori, Laura AU - Fiori L AD - Metabolic Diseases Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Calcaterra, Valeria AU - Calcaterra V AD - Pediatric Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. AD - Pediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, Pavia, Italy. FAU - Zuccotti, Gianvincenzo AU - Zuccotti G AD - Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy. AD - Pediatric Unit, Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. LA - eng PT - Journal Article DEP - 20260721 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13433604 OTO - NOTNLM OT - citrullinemia type I OT - growth OT - infants OT - inherited metabolic disorders (IMD) OT - nutritional management OT - phenylketonuria (PKU) OT - quality of life OT - telemedicine COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/05 06:41 MHDA- 2026/08/05 06:42 PMCR- 2026/07/21 CRDT- 2026/08/05 05:03 PHST- 2026/04/30 00:00 [received] PHST- 2026/06/29 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/08/05 06:42 [medline] PHST- 2026/08/05 06:41 [pubmed] PHST- 2026/08/05 05:03 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - 10.3389/fped.2026.1869508 [doi] PST - epublish SO - Front Pediatr. 2026 Jul 21;14:1869508. doi: 10.3389/fped.2026.1869508. eCollection 2026. PMID- 42553178 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260805 LR - 20260813 IS - 2096-7071 (Electronic) IS - 2096-7071 (Linking) VI - 8 IP - 28 DP - 2026 Jul 10 TI - Nomogram for Predicting Myopia Risk in Chinese Children and Adolescents Aged 5-19 Years - 10 PLADs, China 2020-2024. PG - 892-897 LID - 10.46234/ccdcw2026.145 [doi] AB - INTRODUCTION: This study aimed to identify the determinants of myopia in children and adolescents across 10 provincial-level administrative divisions (PLADs) and develop a predictive nomogram to aid risk identification. METHODS: From November 2020 to July 2024, 32,075 students aged 5-19 years were selected using stratified cluster random sampling across 10 PLADs. Myopia screening and questionnaires were used to collect demographic, behavioral, and environmental data. To account for the hierarchical structure of the data, multilevel logistic regression was employed to identify the independent predictors of myopia. A nomogram was constructed based on the regression coefficients, following the Transparent Reporting of a multivariable prediction model for Individual Prognosis Or Diagnosis (TRIPOD) guidelines. The model performance was evaluated using receiver operating characteristic (ROC) curves, area under the curve (AUC), calibration plots, and decision curve analysis (DCA). RESULTS: The prevalence of myopia was 29.49% (9,460/32,075). Sex, daily frequency of school eye exercises, homework/reading and writing time after school, time spent on computers, 33-centimeter eye-to-book distance during reading and writing, 3-meter eye-to-TV distance, lying or prone position for reading/screen, parent-controlled game time, and parental myopia were identified as significant predictors. The nomogram demonstrated strong predictive ability, with AUCs of 0.80 (training) and 0.81 (validation), good calibration, and a high net clinical benefit in DCA. CONCLUSION: The developed nomogram proved effective for identifying high-risk children, supporting personalized risk stratification, and targeting early intervention strategies. CI - Copyright (c) 2026 by Chinese Center for Disease Control and Prevention & Chinese Academy of Preventive Medicine. FAU - Liu, Keke AU - Liu K AD - School of Public Health, Capital Medical University, Beijing, China. AD - School Health Center, Beijing Center for Disease Control and Prevention, Beijing, China. FAU - Qin, Ran AU - Qin R AD - School Health Center, Beijing Center for Disease Control and Prevention, Beijing, China. FAU - Luo, Huijuan AU - Luo H AD - School Health Center, Beijing Center for Disease Control and Prevention, Beijing, China. FAU - Guo, Xin AU - Guo X AD - School of Public Health, Capital Medical University, Beijing, China. AD - School Health Preparation Office, Chinese Center for Disease Control and Prevention & Chinese Academy of Preventive Medicine, Beijing, China. LA - eng PT - Journal Article PL - China TA - China CDC Wkly JT - China CDC weekly JID - 101767554 PMC - PMC13433276 OTO - NOTNLM OT - Children and adolescents OT - Myopia OT - Nomogram OT - Risk factors COIS- No conflicts of interest. EDAT- 2026/08/05 06:42 MHDA- 2026/08/05 06:43 PMCR- 2026/07/10 CRDT- 2026/08/05 04:52 PHST- 2026/02/09 00:00 [received] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/08/05 06:43 [medline] PHST- 2026/08/05 06:42 [pubmed] PHST- 2026/08/05 04:52 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - ccdcw-8-28-892 [pii] AID - 10.46234/ccdcw2026.145 [doi] PST - ppublish SO - China CDC Wkly. 2026 Jul 10;8(28):892-897. doi: 10.46234/ccdcw2026.145. PMID- 42553102 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260805 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Associations between early childhood appetitive traits and dietary diversity in school-age children: a two-year longitudinal follow-up study. PG - 1824771 LID - 10.3389/fnut.2026.1824771 [doi] LID - 1824771 AB - BACKGROUND: Dietary diversity reflects diet quality and is critical for children's growth and long-term health. Appetitive traits affect dietary habits and long-term food choices. However, few studies have explored the associations between early childhood appetitive traits and dietary diversity in school-age children using standardized and validated tools. METHODS: We recruited 208 kindergarten children aged 5-6 years, with 194 completing the two-year longitudinal follow-up. Appetitive traits were evaluated at age 5-6 using the Child Eating Behavior Questionnaire (CEBQ). Dietary diversity was assessed 2 years later via the Dietary Diversity Score (DDS). Binary logistic regressions were carried out to assess the associations between early childhood appetitive traits and dietary diversity. Inverse probability weighting (IPW) was conducted in complete cases to test the robustness of the main results. RESULTS: Higher food fussiness at 5-6 years was significantly associated with a lower likelihood of high DDS 2 years later (OR = 0.521, 95% CI: 0.327-0.830). No significant sex interactions were observed for these associations. CONCLUSION: Food fussiness at 5-6 years was associated with dietary diversity in school-age children. These findings underscore the relevance of early appetitive traits to dietary diversity and provide evidence-based insights for promoting children's nutrition. CI - Copyright (c) 2026 Mu, Bu, Xu, Yuan, Dai, Lv, Liu, Tang, Zhang and Jin. FAU - Mu, Yuhong AU - Mu Y AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Bu, Duhan AU - Bu D AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Xu, Xiaowen AU - Xu X AD - Department of Endocrinology, Children's Hospital of Soochow University, Suzhou, China. FAU - Yuan, Jing AU - Yuan J AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Dai, Xinxin AU - Dai X AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Lv, Weiqing AU - Lv W AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Liu, Yan AU - Liu Y AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Tang, Jiachen AU - Tang J AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Zhang, Libing AU - Zhang L AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. FAU - Jin, Yu AU - Jin Y AD - Department of Pediatrics, Yangzhou Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yangzhou, China. LA - eng PT - Journal Article DEP - 20260721 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13433194 OTO - NOTNLM OT - appetitive traits OT - child eating behavior questionnaire OT - children OT - dietary diversity OT - dietary diversity score COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/05 06:42 MHDA- 2026/08/05 06:43 PMCR- 2026/07/21 CRDT- 2026/08/05 04:42 PHST- 2026/03/06 00:00 [received] PHST- 2026/07/02 00:00 [revised] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/08/05 06:43 [medline] PHST- 2026/08/05 06:42 [pubmed] PHST- 2026/08/05 04:42 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - 10.3389/fnut.2026.1824771 [doi] PST - epublish SO - Front Nutr. 2026 Jul 21;13:1824771. doi: 10.3389/fnut.2026.1824771. eCollection 2026. PMID- 42552914 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260805 LR - 20260813 IS - 2287-3732 (Print) IS - 2287-3740 (Electronic) IS - 2287-3732 (Linking) VI - 15 IP - 3 DP - 2026 Jul TI - Discrepancies between preschoolers' self-perceived healthy eating practices and parental assessments: a cross-sectional study in South Korea. PG - 184-190 LID - 10.7762/cnr.2026.0009 [doi] AB - OBJECTIVE: Although healthy dietary habits established in early childhood are critical for lifelong health, most previous studies have relied predominantly on parental proxy reports rather than children's self-perceptions. This study compared preschoolers' self-perceived healthy dietary practices with their parents' evaluations and examined discrepancies between them. METHODS: This study included 243 preschoolers aged 2 to 7 years and their parents, recruited from daycare centers in Cheonan, South Korea. Data were collected using the validated, structured, self-administered Healthy Eating Practice Questionnaire, which assessed nutrition and hygiene. Mean Healthy Eating Practice Scores were compared between preschoolers and their parents using paired t-tests, and stratified analyses were conducted by sex and age. RESULTS: Preschoolers rated their healthy dietary practices significantly higher than their parents did (P<0.001). The discrepancy was greater for nutrition than for hygiene, with hygiene ratings more consistent. This domain-specific pattern was consistent across sexes and age groups. When stratified by sex and age, preschooler-parent Healthy Eating Practice Score differences were significantly higher in boys than in girls (25.0+/-21.0 vs. 20.0+/-14.9, respectively; P=0.035). CONCLUSION: Discrepancies between preschoolers' self-perceptions and their parents' evaluations suggest that incorporating both perspectives is essential for accurately assessing children's dietary practices. These findings support the development of dual-perspective dietary assessment and education strategies in early childhood. FAU - An, Jiwon AU - An J AD - Department of Food Science and Nutrition, Dankook University, Cheonan, Korea. FAU - Lee, Seulgi AU - Lee S AD - Department of Food Science and Nutrition, Dankook University, Cheonan, Korea. FAU - Kim, Kirang AU - Kim K AD - Department of Food Science and Nutrition, Dankook University, Cheonan, Korea. LA - eng PT - Journal Article DEP - 20260731 PL - Korea (South) TA - Clin Nutr Res JT - Clinical nutrition research JID - 101592483 PMC - PMC13447742 OTO - NOTNLM OT - Eating behavior OT - Parents OT - Perception OT - Preschool COIS- Conflict of Interest None. EDAT- 2026/08/05 06:42 MHDA- 2026/08/05 06:43 PMCR- 2026/07/31 CRDT- 2026/08/05 03:35 PHST- 2026/03/11 00:00 [received] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/08/05 06:43 [medline] PHST- 2026/08/05 06:42 [pubmed] PHST- 2026/08/05 03:35 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - cnr.2026.0009 [pii] AID - cnr-2026-0009 [pii] AID - 10.7762/cnr.2026.0009 [doi] PST - ppublish SO - Clin Nutr Res. 2026 Jul;15(3):184-190. doi: 10.7762/cnr.2026.0009. Epub 2026 Jul 31. PMID- 42552546 OWN - NLM STAT- MEDLINE DCOM- 20260805 LR - 20260927 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Aug 4 TI - tVNS and obesity-related inflammation: a prospective sham-controlled randomized crossover study protocol. LID - 10.1186/s40359-026-05219-5 [doi] LID - 1133 AB - BACKGROUND: Overweight and obesity are characterized by detrimental effects on energy metabolism and an increase in adipose tissue, leading to chronic low-grade inflammation. This metaflammation may contribute to mental symptoms, such as reduced mood and motivation. Inflammatory processes are modulated by the cholinergic anti-inflammatory pathway (CAIP) that can be targeted with vagus nerve stimulation (VNS). However, the effects of non-invasive transcutaneous VNS (tVNS) on inflammation have predominantly been investigated in small feasibility studies in humans. Whereas acute anti-inflammatory effects of tVNS have been reported, no study has investigated the effect of daily home-based application on obesity-related metaflammation to date. METHODS: To assess tVNS-induced effects on inflammation, motivation, and mood, we are conducting a single-blind, randomized crossover study in participants with an elevated BMI (target N = 60, 27-35 kg/m(2), 18-40 y). Participants will self-administer high- (active) and low-intensity (sham) stimulation daily (>/= 30 min) for ~ 14 days each (>/= 7 d washout). We will assess peripheral (cytokine levels, circulating immune cells) and central (diffusion weighted imaging) inflammation, motivation (using an effort allocation task during functional MRI), and mood at baseline and after each stimulation phase. During each stimulation phase, participants will complete daily ecological momentary assessments of mood and food choices. We will use mixed-effects models to evaluate differences in slopes of high- vs. low-intensity tVNS. DISCUSSION: This study uses a 14-day home-based tVNS protocol (>/= 30 min daily) accompanied by daily ecologocial momentary assessments to investigate mid-term effects on chronic low-grade inflammation, mood, and motivation. The multimodal study design including a comprehensive panel of peripheral and central inflammatory markers enables the integration of inflammatory and behavioral outcomes and will provide important evidence regarding the efficacy of tVNS in chronic inflammation, based on a study with sufficient statistical power. In addition, the study could provide pathophysiological insights into the link between obesity and symptoms of depression via inflammatory processes. Ultimately, the study will facilitate future research on vagus nerve stimulation to complement the current set of therapies in overweight and obesity. TRIAL REGISTRATION: The study has been preregistered at ClinicalTrials.gov ( https://clinicaltrials.gov/study/NCT06954844 ) on March 21, 2025, Version 1. CI - (c) 2026. The Author(s). FAU - Kaluza, Luisa AU - Kaluza L AUID- ORCID: 0009-0006-1450-0163 AD - Department of Psychiatry and Psychotherapy, Section of Medical Psychology, University Hospital Bonn, University of Bonn, Venusberg Campus 1, Bonn, 53127, Germany. AD - Department of Neuroimmunology and Neuromuscular Diseases, Centre for Neurology, University Hospital Bonn, University of Bonn, Bonn, Germany. FAU - Kuhnel, Anne AU - Kuhnel A AUID- ORCID: 0000-0003-3066-3801 AD - Department of Psychiatry and Psychotherapy, Section of Medical Psychology, University Hospital Bonn, University of Bonn, Venusberg Campus 1, Bonn, 53127, Germany. AD - German Center for Mental Health (DZPG), partner site Tubingen, Tubingen, Germany. FAU - Picon-Galindo, Ernesto AU - Picon-Galindo E AUID- ORCID: 0000-0001-7174-6561 AD - Institute of Innate Immunity, Biophysical Imaging, University Hospital Bonn, University of Bonn, Bonn, Germany. FAU - Hergenrother, Mona AU - Hergenrother M AD - Department of Psychiatry and Psychotherapy, Section of Medical Psychology, University Hospital Bonn, University of Bonn, Venusberg Campus 1, Bonn, 53127, Germany. FAU - Alkhateeb, Hesham AU - Alkhateeb H AD - Department of Psychiatry and Psychotherapy, Section of Medical Psychology, University Hospital Bonn, University of Bonn, Venusberg Campus 1, Bonn, 53127, Germany. FAU - Michalski, Simon AU - Michalski S AD - Department of Psychiatry and Psychotherapy, Section of Medical Psychology, University Hospital Bonn, University of Bonn, Venusberg Campus 1, Bonn, 53127, Germany. FAU - Ribeiro, Dalila Juliana Silva AU - Ribeiro DJS AD - Institute of Innate Immunity, Biophysical Imaging, University Hospital Bonn, University of Bonn, Bonn, Germany. FAU - Schmidt, Susanne V AU - Schmidt SV AD - Institute of Clinical Chemistry and Clinical Pharmacology, University Hospital Bonn, Bonn, 53127, Germany. FAU - Wachten, Dagmar AU - Wachten D AUID- ORCID: 0000-0003-4800-6332 AD - Institute of Innate Immunity, Biophysical Imaging, University Hospital Bonn, University of Bonn, Bonn, Germany. FAU - Kroemer, Nils B AU - Kroemer NB AUID- ORCID: 0000-0002-9552-3781 AD - Department of Psychiatry and Psychotherapy, Section of Medical Psychology, University Hospital Bonn, University of Bonn, Venusberg Campus 1, Bonn, 53127, Germany. nkroemer@uni-bonn.de. AD - Department of Psychiatry and Psychotherapy, Tubingen Center for Mental Health, University of Tubingen, Tubingen, Germany. nkroemer@uni-bonn.de. AD - German Center for Mental Health (DZPG), partner site Tubingen, Tubingen, Germany. nkroemer@uni-bonn.de. AD - German Center for Diabetes Research (DZD), Neuherberg, Germany. nkroemer@uni-bonn.de. LA - eng SI - ClinicalTrials.gov/NCT06954844 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260804 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 RN - 0 (Cytokines) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - Affect MH - Cross-Over Studies MH - Cytokines/blood MH - *Inflammation/therapy/etiology MH - Motivation MH - *Obesity/complications/therapy MH - Prospective Studies MH - Single-Blind Method MH - *Vagus Nerve Stimulation/methods MH - Randomized Controlled Trials as Topic PMC - PMC13435442 OTO - NOTNLM OT - Effort OT - Metaflammation OT - Motivation OT - Overweight OT - Vagus nerve stimulation COIS- Declarations. Ethics approval and consent to participate: The study was approved by the ethics committee of the Medical Faculty at the University of Bonn (327/23-EP) prior to participant recruitment. All procedures are conducted in accordance with the Declaration of Helsinki. Prior to participation, all individuals provide written informed consent after being given sufficient time for consideration and the opportunity to ask questions to the study team. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/08/05 06:42 MHDA- 2026/08/05 06:43 PMCR- 2026/08/04 CRDT- 2026/08/05 00:28 PHST- 2026/07/11 00:00 [received] PHST- 2026/07/17 00:00 [accepted] PHST- 2026/08/05 06:43 [medline] PHST- 2026/08/05 06:42 [pubmed] PHST- 2026/08/05 00:28 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - 10.1186/s40359-026-05219-5 [pii] AID - 5219 [pii] AID - 10.1186/s40359-026-05219-5 [doi] PST - epublish SO - BMC Psychol. 2026 Aug 4;14(1):1133. doi: 10.1186/s40359-026-05219-5. PMID- 42552509 OWN - NLM STAT- Publisher LR - 20260805 IS - 1179-2035 (Electronic) IS - 0112-1642 (Linking) DP - 2026 Aug 4 TI - Diagnostic and Prognostic Accuracy of Cardiorespiratory Fitness for Detecting Cardiovascular Risk and Mitochondrial Disorders: An Overview of Systematic Reviews with Meta-Analyses. LID - 10.1007/s40279-026-02503-7 [doi] AB - BACKGROUND: Cardiorespiratory fitness (CRF) is a powerful predictor of current and future health across all age groups. Recognising CRF's ability to screen health-related outcomes is essential for supporting its use in clinical practice. OBJECTIVE: The aim was to evaluate the health-related diagnostic and prognostic accuracy of CRF using an overview of systematic reviews. METHODS: Five bibliographic databases (MEDLINE, Embase, Scopus, CINAHL and SPORTDiscus) were searched from January 2002 to April 2025 to identify systematic reviews with meta-analyses that reported on the health-related diagnostic and prognostic accuracy of CRF. The results were presented using forest plots, with the certainty of evidence assessed by a modified Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach. RESULTS: Of the 10,796 papers identified, six systematic reviews with meta-analyses (n = 31,171 observations) were included. Of these, five examined cardiovascular disease, events, or risk, and one examined mitochondrial disorders. CRF was measured objectively or estimated by exercise as maximum or peak oxygen consumption, ventilatory efficiency or fluctuation, or exercise performance or tolerance. All included reviews were graded as having low to critically low quality. CRF demonstrated high prognostic accuracy for predicting severe cardiovascular events in adults with heart failure, with moderate certainty (diagnostic odds ratio [dOR] 4.1-8.1; area under the curve of a summary receiver operating characteristic curve [SROC AUC] 0.73-0.77), and moderate-to-high diagnostic accuracy for detecting coronary artery disease in adults with type 2 diabetes or with suspected coronary artery disease with very low certainty (dOR 2.3-7.6; SROC AUC 0.66-0.79), mitochondrial disorders among adults with high certainty (dOR 18.1-26.6; SROC AUC 0.70-0.83), and cardiovascular disease risk among apparently healthy children and adolescents with low certainty (dOR 3.6-5.7; SROC AUC 0.64-0.71). CONCLUSIONS: CRF detects cardiovascular disease and mitochondrial disorders and predicts cardiovascular events among adults with chronic conditions and detects cardiovascular risk among apparently healthy children; however, the certainty of evidence ranged from very low to high certainty due to methodological limitations. Further research is needed to generate high-quality diagnostic evidence for CRF across diverse health outcomes and age groups in the general population. TRIAL REGISTRATION: PROSPERO CRD42022370149. CI - (c) 2026. The Author(s). FAU - Fraser, Brooklyn J AU - Fraser BJ AUID- ORCID: 0000-0002-1752-5431 AD - Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7001, Australia. brooklyn.fraser@utas.edu.au. AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), School of Allied Health and Human Performance, Adelaide University, Adelaide, SA, Australia. brooklyn.fraser@utas.edu.au. FAU - Gower, Bethany AU - Gower B AUID- ORCID: 0000-0001-6969-6913 AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), School of Allied Health and Human Performance, Adelaide University, Adelaide, SA, Australia. FAU - Stanesby, Oliver AU - Stanesby O AUID- ORCID: 0000-0002-5996-5881 AD - Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7001, Australia. AD - Baker Heart and Diabetes Institute, Melbourne, VIC, Australia. FAU - Magnussen, Costan G AU - Magnussen CG AUID- ORCID: 0000-0002-6238-5730 AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), School of Allied Health and Human Performance, Adelaide University, Adelaide, SA, Australia. AD - Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. AD - Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. FAU - Cadenas-Sanchez, Cristina AU - Cadenas-Sanchez C AUID- ORCID: 0000-0002-4513-9108 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. AD - Department of Cardiology, Stanford University, Stanford, CA, USA. AD - Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Granada, Spain. FAU - Chaput, Jean-Philippe AU - Chaput JP AUID- ORCID: 0000-0002-5607-5736 AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. AD - Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. FAU - Manyanga, Taru AU - Manyanga T AUID- ORCID: 0000-0001-5461-5981 AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. AD - Division of Medical Sciences, University of Northern British Columbia, Prince George, BC, Canada. FAU - McGrath, Ryan AU - McGrath R AUID- ORCID: 0000-0002-0644-5524 AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), School of Allied Health and Human Performance, Adelaide University, Adelaide, SA, Australia. AD - Healthy Aging North Dakota (HAND), North Dakota State University, Fargo, ND, USA. AD - Department of Health, Nutrition, and Exercise Sciences, North Dakota State University, Fargo, ND, USA. AD - Fargo VA Healthcare System, Fargo, ND, USA. AD - Department of Geriatrics, University of North Dakota, Grand Forks, ND, USA. FAU - Merucci, Katherine AU - Merucci K AUID- ORCID: 0000-0003-1981-7013 AD - Health Library, Health Canada, Ottawa, ON, Canada. FAU - Myers, Jonathan AU - Myers J AUID- ORCID: 0000-0003-2592-136X AD - Department of Cardiology, Stanford University, Stanford, CA, USA. AD - Veterans Affairs Palo Alto Health Care System, Palo Alto, CA, USA. FAU - Ortega, Francisco B AU - Ortega FB AUID- ORCID: 0000-0003-2001-1121 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y Nutricion (CIBERobn), Instituto de Salud Carlos III, Granada, Spain. AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. FAU - Singh, Ben AU - Singh B AUID- ORCID: 0000-0002-7227-2406 AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), School of Allied Health and Human Performance, Adelaide University, Adelaide, SA, Australia. FAU - Prince, Stephanie A AU - Prince SA AUID- ORCID: 0000-0001-6729-5649 AD - Centre for Surveillance and Applied Research, Public Health Agency of Canada, Ottawa, ON, Canada. AD - School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. FAU - Lang, Justin J AU - Lang JJ AUID- ORCID: 0000-0002-1768-319X AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), School of Allied Health and Human Performance, Adelaide University, Adelaide, SA, Australia. AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. AD - Centre for Surveillance and Applied Research, Public Health Agency of Canada, Ottawa, ON, Canada. AD - School of Epidemiology and Public Health, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada. FAU - Tomkinson, Grant R AU - Tomkinson GR AUID- ORCID: 0000-0001-7601-9670 AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), School of Allied Health and Human Performance, Adelaide University, Adelaide, SA, Australia. LA - eng GR - 106588/National Heart Foundation of Australia/ GR - PID2023-148404OB-I00/MICIU/AEI /10.13039/501100011033 and ERDF funds, EU/ GR - 101028929/European Union's Horizon 2020/ PT - Journal Article PT - Systematic Review DEP - 20260804 PL - New Zealand TA - Sports Med JT - Sports medicine (Auckland, N.Z.) JID - 8412297 SB - IM COIS- Declarations. Conflict of interest/Competing interests: The authors declare no conflicts of interest. Funding: No funding was provided for this study. BJF is supported by a National Heart Foundation of Australia Postdoctoral Fellowship (106588). FBO's research activity is supported by the Grant PID2023-148404OB-I00 funded by MICIU/AEI/ https://doi.org/10.13039/501100011033 and ERDF funds, EU. CC-S is supported by a grant from the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska Curie grant agreement No 101028929. Availability of data, code, and other materials: All materials from this study have been included as Electronic Supplementary Material. Additional materials are available upon request. Disclaimer: The content and views expressed in this article are those of the authors and do not necessarily reflect those of the Government of Canada. Authors' contributions: BJF screened the records, extracted the data, assessed the methodological quality of each systematic review, took responsibility for the integrity of the data, synthesised the results, and co-wrote the manuscript. BG screened the records, assessed the certainty of evidence, synthesised the results, and co-wrote the manuscript. OS extracted the data, assessed the methodological quality of each systematic review, and critically reviewed the manuscript for important intellectual content. CC-S, JPC, TM, and BS screened the records, contributed to the interpretation of results, and critically reviewed the manuscript for important intellectual content. CGM, JM, RM, and FBO contributed to the interpretation of results and critically reviewed the manuscript for important intellectual content. KM designed and executed the systematic search strategy and critically reviewed the manuscript for important intellectual content. SAP and JJL developed the research question, designed the systematic review, screened the records, contributed to the interpretation of results, and critically reviewed the manuscript for important intellectual content. GRT developed the research question, designed the systematic review, screened the records, had full access to the data, synthesised the results, and co-wrote the manuscript. All authors read and approved the final version of the manuscript. Ethics approval: Not applicable. Consent to participate: Not applicable. Consent for publication: Not applicable. EDAT- 2026/08/05 06:42 MHDA- 2026/08/05 06:42 CRDT- 2026/08/05 00:17 PHST- 2026/07/11 00:00 [accepted] PHST- 2026/08/05 06:42 [medline] PHST- 2026/08/05 06:42 [pubmed] PHST- 2026/08/05 00:17 [entrez] AID - 10.1007/s40279-026-02503-7 [pii] AID - 10.1007/s40279-026-02503-7 [doi] PST - aheadofprint SO - Sports Med. 2026 Aug 4. doi: 10.1007/s40279-026-02503-7. PMID- 42550031 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260813 IS - 1520-6300 (Electronic) IS - 1042-0533 (Print) IS - 1042-0533 (Linking) VI - 38 IP - 8 DP - 2026 Aug TI - Associations Between Motor Competence, Health-Related Physical Fitness, and Mental Health Outcomes in Spanish Adolescents: The ENERGYCO Study. PG - e70318 LID - 10.1002/ajhb.70318 [doi] LID - e70318 AB - BACKGROUND: Motor competence (MC) has been proposed as an important correlate of physical and mental health during youth. However, evidence examining its associations with both health-related physical fitness and mental health in Spanish adolescents remains limited. OBJECTIVE: To examine the associations between objectively assessed MC and health-related physical fitness and mental health in Spanish adolescents. METHODS: This cross-sectional study included 273 adolescents (46.9% girls; 12-17 years). MC was assessed using the Bruininks-Oseretsky Test of Motor Proficiency Short Form (BOT-2 SF). Anthropometric measures, physical fitness, and mental health were assessed using validated protocols and questionnaires. Two-level linear mixed-effects and generalized estimating equation logistic regression models were adjusted for sex, biological maturation, socioeconomic status, and self-reported physical activity. RESULTS: Higher MC was consistently associated with more favorable health-related physical fitness outcomes (all p < 0.001) and with a greater likelihood of meeting established health-related physical fitness criteria. MC was inversely associated with waist-to-height ratio (p = 0.028), whereas no consistent associations were observed with other anthropometric measures or mental health outcomes. CONCLUSION: Higher MC was consistently associated with health-related physical fitness in Spanish adolescents, whereas associations with anthropometric measures and mental health were limited. Future adequately powered longitudinal and intervention studies are warranted to clarify the directionality of these relationships. CI - (c) 2026 Wiley Periodicals LLC. FAU - Valle-Munoz, Victor Manuel AU - Valle-Munoz VM AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. FAU - Avila-Garcia, Manuel AU - Avila-Garcia M AD - Inmaculada Teacher Training Centre, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. AD - Faculty of Sport Sciences, Universidad Isabel I, Burgos, Spain. FAU - Campos-Garzon, Pablo AU - Campos-Garzon P AD - SPORT Research Group (CTS-1024), CIBIS (Centro de Investigacion Para el Bienestar y la Inclusion Social) Research Center, University of Almeria, Almeria, Spain. AD - Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. FAU - Perez De Arrilucea Le Floc'h, Unai A AU - Perez De Arrilucea Le Floc'h UA AD - Faculty of Sport Sciences, Universidad Isabel I, Burgos, Spain. AD - Faculty of Health Sciences, Universidad Europea de Valencia, Valencia, Spain. FAU - Estevan, Isaac AU - Estevan I AD - AFIPS Research Group, Department of Teaching of Physical Education, Arts and Music, University of Valencia, Valencia, Spain. FAU - Villa-Gonzalez, Emilio AU - Villa-Gonzalez E AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. LA - eng GR - FPU23/01608/V.M.V.-M.: FPU Predoctoral Research Fellowship from the Spanish Ministry of Universities/ GR - PID2021-126126OA-I00/Spanish Ministry of Science and Innovation (MCIN) and the State Research Agency/ GR - BG24/00004/P.C.-G.: Spanish Ministry of Universities/ GR - PRX24/00031/I.-E.: Spanish Ministry of Science, Innovation and Universities (Gobierno de Espana)/ PT - Journal Article PL - United States TA - Am J Hum Biol JT - American journal of human biology : the official journal of the Human Biology Council JID - 8915029 SB - IM MH - Humans MH - *Physical Fitness MH - Spain MH - Female MH - *Mental Health/statistics & numerical data MH - Cross-Sectional Studies MH - Adolescent MH - *Motor Skills MH - Male MH - Child PMC - PMC13436258 OTO - NOTNLM OT - adolescence OT - gross motor skills OT - health OT - physical education COIS- The authors declare no conflicts of interest. EDAT- 2026/08/04 12:46 MHDA- 2026/08/04 12:47 PMCR- 2026/08/04 CRDT- 2026/08/04 10:03 PHST- 2026/07/01 00:00 [revised] PHST- 2026/04/10 00:00 [received] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/08/04 12:47 [medline] PHST- 2026/08/04 12:46 [pubmed] PHST- 2026/08/04 10:03 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - AJHB70318 [pii] AID - 10.1002/ajhb.70318 [doi] PST - ppublish SO - Am J Hum Biol. 2026 Aug;38(8):e70318. doi: 10.1002/ajhb.70318. PMID- 42549732 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260813 IS - 1552-695X (Electronic) IS - 1534-7354 (Print) IS - 1534-7354 (Linking) VI - 25 DP - 2026 Jan-Dec TI - Caregiver's Kitchen: A Mixed Methods Feasibility Study of a Culinary Medicine and Coaching Intervention for Caregivers of Children With Cancer. PG - 15347354261476641 LID - 10.1177/15347354261476641 [doi] LID - 15347354261476641 AB - Caregivers play a central role in managing the nutrition challenges that arise during pediatric cancer treatment, yet many report insufficient knowledge, low confidence, and limited support for preparing foods that address treatment-related side effects. Culinary medicine, integrating nutrition education with hands-on cooking, may help caregivers navigate these challenges, but caregiver-centered programs in pediatric oncology are scarce. Caregiver's Kitchen is an eight-week, remotely delivered culinary medicine and coaching intervention designed to strengthen caregiver nutrition knowledge, cooking skills, and confidence in managing their child's symptoms. This mixed-methods feasibility study evaluated program feasibility and acceptability and explored caregiver experiences to inform refinement of a future trial. Ten caregiver-child dyads were enrolled. Caregivers participated in four live virtual culinary workshops and four individualized telephone coaching sessions. Feasibility outcomes included recruitment, retention, assessment completion, engagement, and acceptability, assessed against predefined progression criteria. Qualitative feedback was collected through post-intervention open-ended survey questions and analyzed using rapid content analysis. Three of five feasibility criteria were met. Recruitment targets were achieved (2-3 dyads/week), and engagement was high, with 80% attending >/=3 workshops and 90% completing >/=2 coaching calls. Acceptability was strong (mean ratings 4.35/5). Assessment completion declined at later time points. Qualitative findings highlighted the usefulness of practical culinary guidance, accessible recipes, and individualized coaching, while identifying scheduling constraints and lengthy assessments as barriers. Caregiver insights informed refinements to enhance feasibility, including transitioning to self-paced modules and streamlining assessments. Findings support progression to a larger pilot trial. FAU - Milliron, Brandy-Joe AU - Milliron BJ AUID- ORCID: 0000-0003-1113-9043 AD - Department of Health Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. RINGGOLD: 15775 FAU - Salman, Khulood AU - Salman K AD - Department of Health Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. RINGGOLD: 15775 FAU - Schlechter, Haley AU - Schlechter H AD - Children's Hospital of Philadelphia, King of Prussia, PA, USA. RINGGOLD: 6567 FAU - Mountain, Paige AU - Mountain P AD - Department of Clinical Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Longo, Gabrielle AU - Longo G AD - Department of Clinical Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA, USA. RINGGOLD: 6567 FAU - Deutsch, Jonathan M AU - Deutsch JM AD - Department of Health Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. RINGGOLD: 15775 FAU - Jubelirer, Tracey AU - Jubelirer T AD - Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. AD - Division of Oncology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. RINGGOLD: 6567 LA - eng PT - Journal Article DEP - 20260804 PL - United States TA - Integr Cancer Ther JT - Integrative cancer therapies JID - 101128834 SB - IM MH - Humans MH - *Caregivers/education/psychology MH - Feasibility Studies MH - *Neoplasms MH - Female MH - Male MH - Child MH - *Cooking/methods MH - Adult MH - Mentoring/methods MH - Middle Aged MH - Surveys and Questionnaires MH - Child, Preschool MH - Health Knowledge, Attitudes, Practice PMC - PMC13438338 OTO - NOTNLM OT - caregiving OT - culinary medicine OT - integrative care OT - nutrition OT - pediatric cancer COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/08/04 12:46 MHDA- 2026/08/04 12:47 PMCR- 2026/08/04 CRDT- 2026/08/04 07:33 PHST- 2026/08/04 12:47 [medline] PHST- 2026/08/04 12:46 [pubmed] PHST- 2026/08/04 07:33 [entrez] PHST- 2026/08/04 00:00 [pmc-release] AID - 10.1177_15347354261476641 [pii] AID - 10.1177/15347354261476641 [doi] PST - ppublish SO - Integr Cancer Ther. 2026 Jan-Dec;25:15347354261476641. doi: 10.1177/15347354261476641. Epub 2026 Aug 4. PMID- 42549391 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Artificial intelligence in nutritional health: sustainable consumers' right to quality of life with special reference to youth. PG - 1817284 LID - 10.3389/fpubh.2026.1817284 [doi] LID - 1817284 AB - BACKGROUND: Maintaining optimal youth nutritional health is an urgent socio-economic imperative that underpins long-term human productivity and rights-based development. However, modern youth cohorts face unique dietary threats caused by the widespread availability of ultra-processed foods, targeted digital marketing, and complex food labeling protocols. Although Artificial Intelligence (AI) presents innovative avenues for personalized dietary profiling, existing systems remain largely technocentric and detached from statutory frameworks or behavioral realities. OBJECTIVE: This study bridges this interdisciplinary divide by evaluating a rights-based, technology-driven framework to improve youth nutritional health. It aims to: (1) empirically evaluate the "Knowledge-Attitude-Practice" (KAP) gap linking statutory consumer rights to real-world eating habits; (2) present the engineering design of a non-commercial Progressive Web Application (PWA) built to translate legal safeguards into daily behavioral changes; and (3) triangulate these findings using data from youth surveys and expert legal and nutritional panels. METHODS: Using a cross-sectional approach based on non-parametric power constraints, a validated survey instrument was completed by a target sample of Indian youth (n = 354, aged 15-25 years). Concurrently, data matrices were compiled from regional legal experts (n = 12) and public nutrition professionals (n = 12) to cross-verify structural bottlenecks. Group variances, demographic dependencies, and rank associations were analyzed using robust non-parametric tests, including One-Way ANOVA, Kruskal-Wallis (H), Welch's t-test, and Kendall's Tau (tau) correlation coefficients. RESULTS: Inferential analysis revealed unexpected demographic trends: undergraduate status predicted significantly higher FSSAI safety awareness than post-graduate status (p = 0.0037), while subjective health ratings exhibited a non-linear relationship with household income (p = 0.0004), peaking in the lower-middle financial tier. Crucially, rank correlation testing revealed that the relationship between statutory knowledge and actual dietary actions is functionally non-existent (tau = -0.001). This near-zero correlation provides clear empirical proof of a pronounced Knowledge-Action Gap, confirming that passive legal literacy fails to influence food selection in modern environments. CONCLUSION: By framing automated behavioral interventions within the constitutional protections of Article 21 of the Constitution of India and the Consumer Protection Act, 2019, this study shows how the open-access PWA (nutrition-zb.pages.dev) can bridge this behavioral gap. This shifts the focus of consumer health informatics from basic self-tracking to a rights-based, systemic public health intervention. CI - Copyright (c) 2026 Indirapriyadarsini, Guttapalam, Mogarala and Guptha. FAU - Indirapriyadarsini, G AU - Indirapriyadarsini G AD - Department of Law, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati, Andhra Pradesh, India. FAU - Guttapalam, Sireesha AU - Guttapalam S AD - Department of Home Science, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati, Andhra Pradesh, India. FAU - Mogarala, Ramyasri AU - Mogarala R AD - Department of Research and Development Cell, Sri Padmavati Mahila Visvavidyalayam (Women's University), Tirupati, Andhra Pradesh, India. FAU - Guptha, Kalpeshkumar L AU - Guptha KL AD - Former Faculty, Gujarat National Law University, Surat, Gujarat, India. LA - eng PT - Journal Article DEP - 20260720 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - *Artificial Intelligence MH - Female MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - *Quality of Life MH - Adult MH - India MH - *Health Knowledge, Attitudes, Practice MH - *Feeding Behavior MH - Surveys and Questionnaires PMC - PMC13431161 OTO - NOTNLM OT - artificial intelligence OT - consumer protection OT - food safety regulations OT - knowledge-attitude-practice (KAP) gap OT - progressive web application (PWA) OT - sustainable development goals OT - sustainable health OT - youth health COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/08/04 12:46 MHDA- 2026/08/04 12:47 PMCR- 2026/07/20 CRDT- 2026/08/04 06:34 PHST- 2026/02/25 00:00 [received] PHST- 2026/06/11 00:00 [revised] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/08/04 12:47 [medline] PHST- 2026/08/04 12:46 [pubmed] PHST- 2026/08/04 06:34 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1817284 [doi] PST - epublish SO - Front Public Health. 2026 Jul 20;14:1817284. doi: 10.3389/fpubh.2026.1817284. eCollection 2026. PMID- 42549124 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260804 LR - 20260827 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Correction: Comparison of Chinese and international birth weight standards in predicting early childhood growth outcomes: a retrospective cohort study. PG - 1905752 LID - 10.3389/fped.2026.1905752 [doi] LID - 1905752 AB - [This corrects the article DOI: 10.3389/fped.2026.1810686.]. CI - (c) 2026 Zhang, Zhang, Gao, Li, Zhang, Liu and Li. FAU - Zhang, Ting AU - Zhang T AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Zhang, Zhenyu AU - Zhang Z AD - School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China. FAU - Gao, Mai AU - Gao M AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Li, Ziyun AU - Li Z AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Zhang, Li AU - Zhang L AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Liu, Huijuan AU - Liu H AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Li, Yan AU - Li Y AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. LA - eng PT - Published Erratum DEP - 20260720 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 EFR - Front Pediatr. 2026 Jun 08;14:1810686. doi: 10.3389/fped.2026.1810686. PMID: 42339296 PMC - PMC13430599 OTO - NOTNLM OT - birth weight OT - growth standards OT - possible risk of overweight OT - predictive validity OT - wasting EDAT- 2026/08/04 12:46 MHDA- 2026/08/04 12:47 PMCR- 2026/07/20 CRDT- 2026/08/04 06:11 PHST- 2026/06/11 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/08/04 12:47 [medline] PHST- 2026/08/04 12:46 [pubmed] PHST- 2026/08/04 06:11 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - 10.3389/fped.2026.1905752 [doi] PST - epublish SO - Front Pediatr. 2026 Jul 20;14:1905752. doi: 10.3389/fped.2026.1905752. eCollection 2026. PMID- 42548181 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261014 IS - 2092-7193 (Electronic) IS - 2092-7193 (Linking) VI - 48 DP - 2026 TI - Device-related differences in blood pressure measurement and their impact on hypertension prevalence in Korean children and adolescents. PG - e2026037 LID - 10.4178/epih.e2026037 [doi] AB - OBJECTIVES: Accurate blood pressure (BP) measurement is essential for reliably estimating hypertension prevalence in population-based surveys. However, evidence supporting the use of oscillometric BP devices in pediatric populations remains limited. This study compared BP measurements obtained using an oscillometric device (OD) and an auscultatory device (AD) and evaluated inter-device agreement and the impact of device choice on hypertension prevalence estimates. METHODS: BP was measured sequentially with the AD and OD in 251 children and adolescents participating in the Korea National Health and Nutrition Examination Survey. Inter-device agreement was assessed using mean differences, limits of agreement, concordance correlation coefficients (CCCs), and regression analyses. Differences in prevalence estimates for elevated blood pressure (EBP) and hypertension were also examined. RESULTS: Mean inter-device differences were minimal for systolic blood pressure (SBP; 0.2+/-5.9 mmHg) but negative for diastolic blood pressure (DBP; -1.5+/-6.1 mmHg), with larger discrepancies in older girls. Agreement was moderate to good for SBP (CCC=0.79) and weaker for DBP (CCC=0.60). Nevertheless, more than 85% of paired measurements were within +/-10 mmHg. Prevalence estimates for EBP (11.6 vs. 10.0%) and hypertension (4.8 vs. 4.4%) were comparable between devices, with relatively high negative agreement and overall agreement. CONCLUSIONS: Despite modest underestimation of DBP in specific subgroups, oscillometric BP measurement showed acceptable agreement with the auscultatory method and yielded similar hypertension prevalence estimates. These findings suggest that ODs may be useful for pediatric BP measurement in public health surveillance systems. FAU - Kim, Sung Hye AU - Kim SH AD - Department of Pediatrics, CHA Bundang Medical Center, CHA University, Seongnam, Korea. FAU - Kim, Yu-Mi AU - Kim YM AD - Department of Preventive Medicine, Hanyang University College of Medicine, Seoul, Korea. AD - Institute for Health and Society, Hanyang University, Seoul, Korea. FAU - Kim, Hack-Lyoung AU - Kim HL AD - Department of Internal Medicine, Boramae Medical Center, Seoul National University College of Medicine, Seoul, Korea. FAU - Park, Sang Min AU - Park SM AD - Division of Cardiology, Department of Internal Medicine, Nowon Eulji Medical Center, Eulji University College of Medicine, Seoul, Korea. FAU - Cho, In-Jeong AU - Cho IJ AD - Division of Cardiology, Department of Internal Medicine, Ewha Womans University Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Korea. FAU - Kim, Dae-Hee AU - Kim DH AD - Division of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea. FAU - Kim, Kwang-Il AU - Kim KI AD - Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea. FAU - Shin, Jinho AU - Shin J AD - Division of Cardiology, Department of Internal Medicine, Hanyang University College of Medicine, Seoul, Korea. FAU - Oh, Kyungwon AU - Oh K AD - Division of Health and Nutrition Survey and Analysis, Bureau of Chronic Disease Prevention and Control, Korea Disease Control and Prevention Agency, Cheongju, Korea. FAU - Lee, Eun Mi AU - Lee EM AD - Division of Cardiology, Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Korea. mdemlee@naver.com. LA - eng PT - Journal Article DEP - 20260727 PL - Korea (South) TA - Epidemiol Health JT - Epidemiology and health JID - 101519472 SB - IM MH - Humans MH - Female MH - *Hypertension/epidemiology/diagnosis MH - Adolescent MH - Republic of Korea/epidemiology MH - Male MH - Child MH - *Blood Pressure Determination/instrumentation/methods MH - Prevalence MH - Oscillometry/instrumentation MH - Nutrition Surveys OTO - NOTNLM OT - Adolescent OT - Blood pressure OT - Blood pressure determination OT - Child OT - Hypertension OT - Oscillometry EDAT- 2026/08/04 06:37 MHDA- 2026/10/14 23:31 CRDT- 2026/08/04 03:09 PHST- 2026/04/16 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/10/14 23:31 [medline] PHST- 2026/08/04 06:37 [pubmed] PHST- 2026/08/04 03:09 [entrez] AID - epih.e2026037 [pii] AID - 10.4178/epih.e2026037 [doi] PST - ppublish SO - Epidemiol Health. 2026;48:e2026037. doi: 10.4178/epih.e2026037. Epub 2026 Jul 27. PMID- 42547597 OWN - NLM STAT- MEDLINE DCOM- 20261026 LR - 20261026 IS - 1432-5241 (Electronic) IS - 0364-216X (Linking) VI - 50 IP - 19 DP - 2026 Oct TI - The Golden Triangle Method: A Novel Simulation Framework for Rhinoplasty Design. PG - 7905-7919 LID - 10.1007/s00266-026-06197-0 [doi] AB - BACKGROUND: Current rhinoplasty simulation relies on subjective landmark planning and compartmentalized parameter analysis, resulting in inconsistent designs. This study introduces a unified geometric framework to assist in the design of harmonious noses. OBJECTIVES: To develop and provide proof-of-concept validation for a geometric framework that systematically determines optimal nasal landmark positions based on facial proportions, and to evaluate its aesthetic acceptability. METHODS: This prospective study included 30 young Turkish women (aged 18-30 years) seeking primary rhinoplasty, evaluated by 20 board-certified plastic surgeons (17 included in Visual Analog Scales analysis after outlier exclusion) and the patients themselves. The Golden Triangle method employs a 36 degrees -apex isosceles triangle to determine key nasal landmarks within a cohesive geometric framework. Simulations were created using GeoGebra (which also calculated nasal ratios and angles) and Adobe Photoshop. Evaluators rated pre- and post-simulation images using Visual Analog Scales (0-100). Technical parameters were evaluated on 5-point Likert scale by surgeons. RESULTS: Patient VAS scores increased from 41.3 +/- 10.1 to 81.9 +/- 3.3 (p < .001; Cohen's d = 5.41), and surgeon ratings improved from 34.7 +/- 6.3 to 72.6 +/- 4.4 (p < .001; Cohen's d = 7.02). The coefficient of variation decreased by 66.2% for patients' and 53.7% for surgeons' ratings, indicating improved interrater agreement on simulation images. Technical parameters reached "ideal" consensus in 93-97% of cases. Nasal ratios and angles converged toward population-specific reference values with reduced variability. CONCLUSIONS: The Golden Triangle method provides a systematic approach to rhinoplasty simulation, significantly improving aesthetic ratings and interrater agreement using affordable software. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 . CI - (c) 2026. Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery. FAU - Erbayat, Yusuf AU - Erbayat Y AUID- ORCID: 0000-0003-3253-6494 AD - Department of Plastic, Reconstructive and Aesthetic Surgery, Recep Tayyip Erdogan University Teaching and Research Hospital, Islampasa Mh. Sehitler Cd. No:74 Merkez, Rize, Turkey. erbayaty@gmail.com. FAU - Kirazoglu, Ahmet AU - Kirazoglu A AD - Department of Plastic, Reconstructive and Aesthetic Surgery, Florya Hospital, Istanbul, Turkey. FAU - Yildiz, Kemalettin AU - Yildiz K AD - Department of Plastic, Reconstructive and Aesthetic Surgery, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20260803 PL - United States TA - Aesthetic Plast Surg JT - Aesthetic plastic surgery JID - 7701756 SB - IM MH - Humans MH - *Rhinoplasty/methods MH - Female MH - Adult MH - Prospective Studies MH - Young Adult MH - Adolescent MH - Esthetics MH - *Nose/anatomy & histology/surgery MH - *Computer Simulation MH - Anatomic Landmarks OTO - NOTNLM OT - Anthropometry OT - Computer simulation OT - Golden Triangle OT - Preoperative planning OT - Rhinoplasty OT - Visual Analog Scale COIS- Declarations. Conflict of interest: The corresponding author has a pending utility model application (Turkish Patent and Trademark Office, Application No: 2026/000080) for the simulation software of the Golden Triangle Method described in this study. All other authors declare that they have no conflicts of interest to disclose. Ethical Approval: This prospective observational study received approval from the University Ethics Committee on March 14, 2024 (Approval No: E-54022451-050.04-144694). All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments. Informed Consent: Informed consent was obtained from all individual participants included in the study. EDAT- 2026/08/04 00:35 MHDA- 2026/10/26 17:31 CRDT- 2026/08/03 23:52 PHST- 2026/01/22 00:00 [received] PHST- 2026/06/28 00:00 [accepted] PHST- 2026/10/26 17:31 [medline] PHST- 2026/08/04 00:35 [pubmed] PHST- 2026/08/03 23:52 [entrez] AID - 10.1007/s00266-026-06197-0 [pii] AID - 10.1007/s00266-026-06197-0 [doi] PST - ppublish SO - Aesthetic Plast Surg. 2026 Oct;50(19):7905-7919. doi: 10.1007/s00266-026-06197-0. Epub 2026 Aug 3. PMID- 42547504 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260824 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Aug 3 TI - Psychosocial and dietary influences on eating behaviors and body mass index among geographically diverse Indian university students. LID - 10.1038/s41598-026-48491-6 [doi] LID - 23865 AB - In the context of India's growing youth population, the interplay of dietary habits, social influences, and psychological factors critically shapes nutritional health outcomes. This cross-sectional study examined the socio-demographic, dietary, psychological, and social determinants of eating behaviour and their association with body mass index (BMI) among 3,150 undergraduate students from agricultural universities across six Indian regions. Using a validated self-administered questionnaire and anthropometric assessments, the study applied Principal Component Analysis (PCA) on 14 binary behavioural variables to identify latent dimensions influencing dietary patterns. The key behavioral components associated with BMI were: External Cues & Emotional Reactivity (PC2) (beta = +2.04, r = + 0.77), characterized by emotional eating and responsiveness to food advertisements; Dietary Practices & Cultural Disengagement (PC1) (beta = -1.54, r = - 0.58), reflecting structured dietary habits independent of cultural food norms; and Positive Affect & Peer Independence (PC6) (beta = -0.84, r = - 0.31), indicating emotionally positive, peer-independent eating. Dietary assessments revealed that although cereal consumption was adequate (100%), notable deficiencies were observed in the intake of green leafy vegetables, milk, and fruits, with consumption levels falling approximately 31-34%, 13-18%, and 10-20% below recommended dietary guidelines, respectively. The findings highlighted that beyond nutritional deficits, psychosocial factors including emotional reactivity and social pressures significantly influence students' weight status. Emotional vulnerability and environmental cues linked with higher BMI, whereas structured eating and emotional well-being are protective. This research underscores the need for gender and socially sensitive nutrition programs in Indian universities to prevent both obesity and undernutrition. CI - (c) 2026. The Author(s). FAU - Mahra, Girijesh Singh AU - Mahra GS AD - ICAR-Indian Agricultural Research Institute, New Delhi, India. girijeshmahra22@gmail.com. FAU - Joshi, Pratibha AU - Joshi P AD - ICAR-Indian Agricultural Research Institute, New Delhi, India. pratijosh12@gmail.com. FAU - Satyapriya AU - Satyapriya AD - ICAR-Indian Agricultural Research Institute, New Delhi, India. satya118ext@gmail.com. FAU - Bishnoi, Sitaram AU - Bishnoi S AD - ICAR-Indian Agricultural Research Institute, New Delhi, India. srext2011@gmail.com. FAU - Sahu, Subhashree AU - Sahu S AD - ICAR-Indian Agricultural Research Institute, New Delhi, India. FAU - Barua, Sukanya AU - Barua S AD - ICAR-Indian Agricultural Research Institute, New Delhi, India. FAU - Burman, Rajarshi Roy AU - Burman RR AD - Division of Agricultural Extension, Indian Council of Agricultural Research, New Delhi, India. LA - eng PT - Journal Article DEP - 20260803 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Male MH - *Students/psychology MH - *Feeding Behavior/psychology MH - India MH - *Body Mass Index MH - Universities MH - Cross-Sectional Studies MH - Young Adult MH - *Diet MH - Adolescent MH - Emotional Eating MH - Adult MH - Surveys and Questionnaires PMC - PMC13434682 OTO - NOTNLM OT - Consumption pattern OT - Demographic dividend OT - Dietary habits OT - Social and psychological factors COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: All methods used in this study were conducted in accordance with the relevant guidelines and regulations. The study received approval from the Research Ethics Committee of the Division of Agricultural Extension, ICAR-Indian Agricultural Research Institute, New Delhi, India (Approval No. Ag Extn/2025/579(A), Date: 01 January, 2025). Informed consent was obtained from each participant, and their confidentiality was ensured throughout the study. EDAT- 2026/08/04 00:35 MHDA- 2026/08/04 00:36 PMCR- 2026/08/03 CRDT- 2026/08/03 23:18 PHST- 2025/07/29 00:00 [received] PHST- 2026/04/08 00:00 [accepted] PHST- 2026/08/04 00:36 [medline] PHST- 2026/08/04 00:35 [pubmed] PHST- 2026/08/03 23:18 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - 10.1038/s41598-026-48491-6 [pii] AID - 48491 [pii] AID - 10.1038/s41598-026-48491-6 [doi] PST - epublish SO - Sci Rep. 2026 Aug 3;16(1):23865. doi: 10.1038/s41598-026-48491-6. PMID- 42547409 OWN - NLM STAT- Publisher LR - 20260803 IS - 1941-2444 (Electronic) IS - 0148-6071 (Linking) DP - 2026 Aug 3 TI - Nutritional and environmental determinants of maturation and disruption of the early life gut microbiome: A narrative review. LID - 10.1002/jpen.70127 [doi] AB - The first 1000 days of life represent a critical window for gut microbiome assembly, with lifelong implications for child growth, immune development, and disease risk. This review synthesizes evidence on maternal, perinatal, and especially nutritional factors that influence early-life intestinal colonization and highlights the consequences of microbial disruptions during this period. In utero exposures and birth-associated factors can profoundly shape microbial development, reducing diversity and beneficial taxa. Nutrition exerts a particularly dominant and modifiable influence: breastfeeding supports Bifidobacterium-rich communities, while formula use and early complementary feeding shape microbiota diversity and metabolic function. Dietary quality, fiber intake, and food diversity are key determinants of microbial maturation and resilience. Undernutrition and inadequate diets contribute to microbial dysbiosis, creating a self-reinforcing cycle of malabsorption, growth failure, and long-term metabolic consequences. Early microbial perturbations are associated with a range of acute and chronic diseases, including necrotizing enterocolitis, obesity, type 1 diabetes, inflammatory bowel disease, and atopic disorders. Strategies to restore microbial balance require further validation, particularly in nutritionally vulnerable populations. The absence of a universal definition for a "healthy" pediatric microbiome limits the development of targeted interventions. Emerging metrics, such as microbiota-for-age z-scores and functional microbiome profiling, may help define microbiota maturity and therapeutic efficacy. CI - (c) 2026 The Author(s). Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals LLC on behalf of American Society for Parenteral and Enteral Nutrition. FAU - Burow, Carly AU - Burow C AUID- ORCID: 0000-0002-2033-672X AD - Faculty of Science, McMaster University, Hamilton, Ontario, Canada. AD - Schulich School of Medicine and Dentistry, University of Western Ontario, London, Ontario, Canada. FAU - Shenderey, Romy AU - Shenderey R AD - Faculty of Health Science, McMaster University, Hamilton, Ontario, Canada. AD - Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. FAU - Chowdhury, Fariha AU - Chowdhury F AUID- ORCID: 0000-0002-9760-186X AD - Faculty of Science, McMaster University, Hamilton, Ontario, Canada. FAU - Shah, Nyah AU - Shah N AD - Faculty of Health Science, McMaster University, Hamilton, Ontario, Canada. AD - Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. FAU - Pai, Nikhil AU - Pai N AUID- ORCID: 0000-0002-7537-6059 AD - Department of Pediatrics, Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. AD - Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. AD - Division of Gastroenterology, Hepatology & Nutrition, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. AD - Center for Microbial Medicine, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. LA - eng PT - Journal Article PT - Review DEP - 20260803 PL - United States TA - JPEN J Parenter Enteral Nutr JT - JPEN. Journal of parenteral and enteral nutrition JID - 7804134 SB - IM OTO - NOTNLM OT - life cycle OT - microbiome OT - nutrition OT - pediatrics OT - research and diseases EDAT- 2026/08/04 00:35 MHDA- 2026/08/04 00:35 CRDT- 2026/08/03 22:02 PHST- 2026/06/16 00:00 [revised] PHST- 2025/11/17 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/08/04 00:35 [medline] PHST- 2026/08/04 00:35 [pubmed] PHST- 2026/08/03 22:02 [entrez] AID - 10.1002/jpen.70127 [doi] PST - aheadofprint SO - JPEN J Parenter Enteral Nutr. 2026 Aug 3. doi: 10.1002/jpen.70127. PMID- 42546580 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260904 IS - 1872-6232 (Electronic) IS - 0378-3782 (Linking) VI - 222 DP - 2026 Nov TI - Validation of the German version of the Brief Infant Sleep Questionnaire (BISQ) and associations with infant development. PG - 106629 LID - S0378-3782(26)00155-6 [pii] LID - 10.1016/j.earlhumdev.2026.106629 [doi] AB - BACKGROUND AND OBJECTIVES: Sleep problems such as prolonged night waking and difficulty falling asleep are common in infants. Sleep problems can affect development and put parents at risk of sleep deprivation, potentially leading to stress and burnout. It is therefore important to identify sleep problems early to facilitate targeted intervention and support. The Brief Infant Sleep Questionnaire (BISQ) developed by Sadeh (2004) is a widely used tool to identify and describe sleep behavior. However, a validated German translation is still missing. The main aim was to validate the German version of the BISQ by evaluating whether it captures age-related changes in sleep behavior whether it can distinguish between infants with and without sleep problems similarly to the original version. METHODS: We validated the German version of the BISQ by secondary analyses including N = 562 infants aged 6 to 24 months from seven independent samples and examined relations to infant development. Caregivers completed the German version of the BISQ. Additionally, parents in a subset of samples completed the Ages and Stages Questionnaires to assess developmental progress. To validate the BISQ against an objective measure, infants in three of the samples wore an actiwatch for a single night. RESULTS: Results showed age-related changes in sleep measures as assessed by the BISQ. Significant moderate correlations emerged between caregiver-reported night sleep duration and night wakings and one night of actigraphy. Additionally, BISQ sleep measures differed between infants whose parents reported a sleep problem and those who did not. The infant's sleep location (in own vs. shared bed) was a significant predictor of BISQ measures. Infants who slept alone in a separate room had more favorable sleep measures than infants who slept in the parent's room or the parent's bed. Daytime sleep duration and the time taken to fall asleep at night were positively associated with gross motor development, whereas nocturnal sleep duration was negatively associated. CONCLUSION: Our findings suggest that the German BISQ is a valid, quick-to-administer instrument for assessing infant sleep. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Konrad, Carolin AU - Konrad C AD - Developmental Psychology, Faculty of Psychology, Ruhr University Bochum, Universitatsstrasse 150, 44801, Bochum, Germany. Electronic address: carolin.konrad@rub.de. FAU - Schneider, Silvia AU - Schneider S AD - Clinical Child and Adolescent Psychology, Mental Health Research and Treatment Center, Faculty of Psychology, Ruhr University Bochum, Massenbergstrasse 9-13, 44787, Bochum, Germany; German Center for Mental Health (DZPG), partner site Bochum/Marburg, Germany. Electronic address: silvia.schneider@rub.de. FAU - Seehagen, Sabine AU - Seehagen S AD - Developmental Psychology, Faculty of Psychology, Ruhr University Bochum, Universitatsstrasse 150, 44801, Bochum, Germany; German Center for Mental Health (DZPG), partner site Bochum/Marburg, Germany. Electronic address: sabine.seehagen@rub.de. LA - eng PT - Journal Article PT - Validation Study DEP - 20260729 PL - Ireland TA - Early Hum Dev JT - Early human development JID - 7708381 SB - IM MH - Humans MH - Infant MH - Surveys and Questionnaires/standards MH - Male MH - *Sleep MH - Female MH - *Child Development MH - Child, Preschool MH - Sleep Duration MH - Germany MH - *Sleep Wake Disorders/diagnosis MH - Actigraphy OTO - NOTNLM OT - Actigraphy OT - Infancy OT - Infant development OT - Sleep OT - Sleep problem COIS- Declaration of competing interest The authors have no competing interests to declare. EDAT- 2026/08/04 00:35 MHDA- 2026/09/04 23:36 CRDT- 2026/08/03 18:07 PHST- 2026/04/30 00:00 [received] PHST- 2026/07/21 00:00 [revised] PHST- 2026/07/26 00:00 [accepted] PHST- 2026/09/04 23:36 [medline] PHST- 2026/08/04 00:35 [pubmed] PHST- 2026/08/03 18:07 [entrez] AID - S0378-3782(26)00155-6 [pii] AID - 10.1016/j.earlhumdev.2026.106629 [doi] PST - ppublish SO - Early Hum Dev. 2026 Nov;222:106629. doi: 10.1016/j.earlhumdev.2026.106629. Epub 2026 Jul 29. PMID- 42545817 OWN - NLM STAT- Publisher LR - 20260803 IS - 1950-6945 (Electronic) IS - 1294-9361 (Linking) DP - 2026 Aug 3 TI - Dietary patterns in children with epilepsy: The role of household environment and clinical comorbidities. LID - 10.1002/epd2.70362 [doi] AB - OBJECTIVE: To evaluate dietary patterns in children with epilepsy and compare them with age- and sex-matched healthy siblings living in the same household environment. Associations between clinical characteristics and dietary adequacy were also examined. METHODS: This cross-sectional study included 58 participants (37 with epilepsy and 21 sibling controls), aged 2-18 years, recruited from a tertiary epilepsy clinic. Dietary intake was assessed using validated, age-specific food frequency questionnaires and classified according to national recommendations. Regression models were used to identify predictors of dietary intake and adequacy. RESULTS: Both groups exhibited inadequate consumption of cereals, fruits, and vegetables, and excessive intake of sugary and ultra-processed foods. No significant differences in dietary intake or adequacy were found between children with epilepsy and their siblings. Within the epilepsy group, motor impairment, and constipation were associated with higher vegetable intake. Conversely, intellectual disability and developmental delay were linked to lower vegetable and fruit intake respectively. Autism spectrum disorder decreased the odds of inadequate vegetable intake, while intellectual disability and younger age increased it. SIGNIFICANCE: Children and adolescents with epilepsy exhibited similar dietary patterns to their healthy siblings, while within the epilepsy group, clinical characteristics, and comorbidities were associated with significant variations in dietary intake and adequacy. These findings suggest that nutritional counseling in pediatric epilepsy should be tailored to clinical comorbidities and family context rather than epilepsy diagnosis alone. CI - (c) 2026 The Author(s). Epileptic Disorders published by Wiley Periodicals LLC on behalf of International League Against Epilepsy. FAU - Oliveira, Ana Claudia Candido AU - Oliveira ACC AD - Child Neurology Service, Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazil. FAU - Santana, Maria Eduarda Pereira AU - Santana MEP AD - Child Neurology Service, Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazil. FAU - Zanin, Giuliane V M AU - Zanin GVM AD - Child Neurology Service, Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazil. FAU - da Silva, Jaqueline Lamas AU - da Silva JL AUID- ORCID: 0009-0007-5482-141X AD - Department of Statistics, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Brazil. FAU - Zeller, Camila Borelli AU - Zeller CB AUID- ORCID: 0000-0002-1042-7425 AD - Department of Statistics, Federal University of Juiz de Fora (UFJF), Juiz de Fora, Brazil. FAU - Coan, Ana Carolina AU - Coan AC AUID- ORCID: 0000-0002-2888-929X AD - Child Neurology Service, Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazil. AD - Brazilian Institute of Neuroscience and Neurotechnology, BRAINN at UNICAMP, Campinas, SP, Brazil. AD - Neuroimaging Laboratory, UNICAMP, Campinas, SP, Brazil. LA - eng GR - 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ PT - Journal Article DEP - 20260803 PL - United States TA - Epileptic Disord JT - Epileptic disorders : international epilepsy journal with videotape JID - 100891853 SB - IM OTO - NOTNLM OT - children OT - diet OT - epilepsy OT - food frequency questionnaire OT - nutritional adequacy EDAT- 2026/08/03 18:37 MHDA- 2026/08/03 18:37 CRDT- 2026/08/03 12:38 PHST- 2026/07/09 00:00 [revised] PHST- 2026/02/13 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/08/03 18:37 [medline] PHST- 2026/08/03 18:37 [pubmed] PHST- 2026/08/03 12:38 [entrez] AID - 10.1002/epd2.70362 [doi] PST - aheadofprint SO - Epileptic Disord. 2026 Aug 3. doi: 10.1002/epd2.70362. PMID- 42545147 OWN - NLM STAT- Publisher LR - 20260803 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 Aug 3 TI - Maternal and newborn health in vegan and omnivore pregnancies: A prospective pilot study (PREGGIE). PG - 2601060261474598 LID - 10.1177/02601060261474598 [doi] AB - BackgroundFew studies have assessed health outcomes in pregnant vegans and their newborns.AimThis study aimed to examine this evidence gap.MethodsThis pilot study compared health parameters of pregnant vegans (n = 32) and omnivores (n = 13), as well as their newborns, in Germany (2019-2022). Maternal body mass index, weight and blood pressure were measured at gestational weeks 9-16 (t1) and 35-38 (t2). Additional assessments included maternal weight gain and excessive weight gain (from the beginning of pregnancy to t2), delivery method, gestational age, preterm birth, sex ratio, birth weight and length, small/large for gestational age, low birth weight, macrosomia, head circumference, and Apgar scores.SummaryNo significant differences were observed between the vegan and omnivore groups for any newborn outcomes, birth characteristics, or maternal health parameters. No preterm births occurred. Small for gestational age was observed in 2 vegan (6%) and 3 omnivore newborns (23%). Low birth weight (<2500 g) occurred in 1 vegan newborn (3%) and in no omnivore newborns. An Apgar score <10 at 10 min was recorded in 1 vegan (3%) and 1 (8%) omnivore newborn (both scoring 8).This study detected no clear adverse effects of a supplemented vegan diet (vitamin B12, iodine, vitamin D, omega-3 fatty acids) during pregnancy. Differences between vegans and omnivores cannot be excluded. The study was underpowered and baseline differences limit group comparability, validity, and generalizability. The study highlights key parameters and underscores the need to maximize group comparability in future research. FAU - Koeder, Christian AU - Koeder C AUID- ORCID: 0000-0002-3761-4220 AD - Institute for Prevention and Cancer Epidemiology (IPE), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. RINGGOLD: 14879 AD - Research Institute for Plant-Based Nutrition (IFPE), Biebertal, Germany. FAU - Feuerlein, Katharina AU - Feuerlein K AD - Fakultat fur Gesundheit, University Witten/Herdecke, Witten, Germany. RINGGOLD: 235785 FAU - Stanislas, Virginie AU - Stanislas V AD - Institute for Prevention and Cancer Epidemiology (IPE), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. RINGGOLD: 14879 FAU - Zerback, Tim AU - Zerback T AD - Research Institute for Plant-Based Nutrition (IFPE), Biebertal, Germany. FAU - Weder, Stine AU - Weder S AD - Research Institute for Plant-Based Nutrition (IFPE), Biebertal, Germany. FAU - Langler, Alfred AU - Langler A AD - Fakultat fur Gesundheit, Professur fur integrative Kinder- und Jugendmedizin, University Witten/Herdecke, Witten, Germany. RINGGOLD: 235785 AD - Gemeinschaftskrankenhaus Herdecke, Klinik fur Kinder- und Jugendmedizin, Herdecke, Germany. FAU - Alexy, Ute AU - Alexy U AD - Institute of Nutritional and Food Sciences-Nutritional Epidemiology, University of Bonn, Bonn, Germany. RINGGOLD: 9374 FAU - Keller, Markus AU - Keller M AD - Research Institute for Plant-Based Nutrition (IFPE), Biebertal, Germany. LA - eng PT - Journal Article DEP - 20260803 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - Vegan diet OT - infants OT - maternal nutrition OT - newborn OT - plant-based diet OT - pregnancy OT - premature birth OT - vegetarian diet EDAT- 2026/08/03 12:42 MHDA- 2026/08/03 12:42 CRDT- 2026/08/03 09:52 PHST- 2026/08/03 12:42 [medline] PHST- 2026/08/03 12:42 [pubmed] PHST- 2026/08/03 09:52 [entrez] AID - 10.1177/02601060261474598 [doi] PST - aheadofprint SO - Nutr Health. 2026 Aug 3:2601060261474598. doi: 10.1177/02601060261474598. PMID- 42544816 OWN - NLM STAT- Publisher LR - 20260803 IS - 1549-8425 (Electronic) IS - 1549-8417 (Linking) DP - 2026 Aug 3 TI - A Prospective Randomized Controlled Simulation Study to Test a Proof-of-Concept Real-Time Periprocedural Decision Support System to Aid in Timely Diagnosis and Intervention on Patient Deterioration. LID - 10.1097/PTS.0000000000001573 [doi] AB - OBJECTIVES: The recent pilot simulation study by Greenberg and colleagues introduced a proof-of-concept audio-visual support system for anesthesiology professional management of perioperative patient deterioration. The results demonstrated that real-time decision support for providers may enhance diagnostic accuracy/efficiency. In collaboration with Greenberg and colleagues, the authors from Massachusetts General Brigham (MGB) similarly developed a realistic operating room simulation environment at Massachusetts General Hospital (MGH) Learning Center. Here, the ability of anesthesiology trainees to accurately diagnose and treat using audio-visual cues was measured. METHODS: This study is a prospective, randomized controlled pilot trial adapted from a recent study further investigating the impact of audio-visual decision support on anesthesiology resident and student nurse anesthetist diagnostic accuracy and efficiency. This study took place entirely at Massachusetts General Hospital Center for Simulation and Innovation. Twenty-one anesthesiology trainees were randomized into 2 groups: (1) standard of care (control) versus (2) audio-visual cue group (experimental). The experimental group received audio-visual cues such as a choice of possible diagnoses from an experienced anesthesiologist and subsequent recommended interventions from the Stanford emergency manual and based on changes in the simulated patient's vitals. Each participant underwent 3 experimental simulations where patient deterioration occurs. These included: anaphylaxis, amniotic fluid embolism (AFE), and pulseless electrical activity (PEA) arrest during a pediatric dental case. Key time points and accuracy of diagnoses and treatment steps were recorded. RESULTS: The simulation scenario recordings for 10 anesthesiology residents and 11 student nurse anesthetists of various training years were investigated. For the anaphylaxis scenario, there was a statistically significant increase in the number of participants who correctly executed intervention 1 in the intervention group compared with the control group (P=0.0015). For the AFE scenario, there was a statistically significant increase in the median time to intervention 1 for SRNAs in the intervention group compared with the control group (P=0.01). However, there was a statistically significant decrease in the median time to intervention 1 for residents in the intervention group compared with the control group (P=0.01). For the pediatric dental scenario, there was a statistically significant increase in the number of participants in the intervention group versus the control group who made the correct diagnosis 2 (P=0.005). In addition, there was a statistically significant increase in the number of participants in the intervention group versus the control group who made the correct diagnosis 3 (P=0.023). CONCLUSIONS: The results indicate that real-time audio and visual cues in a simulated operative environment may improve time to diagnosis and treatment. This effect has now been investigated across the training spectrum from resident trainees to attendings. On the basis of observations from these simulations, this mode of simulation can be an effective educational tool for simulation-based learning exercises. In education or real-time practice, additional dedicated research and development of decision support technology could be beneficial in improving safety during periprocedural care by guiding best training practices. CI - Copyright (c) 2026 Wolters Kluwer Health, LLC. All rights reserved. FAU - Dinkel, Anthony AU - Dinkel A AD - Department of Anesthesiology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA. FAU - Talluto, Justin AU - Talluto J FAU - Chinthareddy, Vikranth AU - Chinthareddy V FAU - McCarthy, Kevin AU - McCarthy K FAU - Vijaykumar, Dolly AU - Vijaykumar D FAU - Greenberg, Steven B AU - Greenberg SB FAU - Locke, Andrew R AU - Locke AR FAU - Heshmat, Claire AU - Heshmat C FAU - Huey, Nathan AU - Huey N FAU - Ellender, Stacey AU - Ellender S FAU - Shapiro, Fred E AU - Shapiro FE LA - eng PT - Journal Article DEP - 20260803 PL - United States TA - J Patient Saf JT - Journal of patient safety JID - 101233393 SB - IM OTO - NOTNLM OT - anesthesia OT - patient safety OT - simulation COIS- F.S. is a consultant for Fresenius-Kabi, USA, and GE Health care. S.G. is the Vice President of the Anesthesia Patient Safety Foundation and has ongoing studies funded by Merck & Co. Inc., Senzime AB, AstraZeneca AB, and Fresenius-Kabi. The remaining authors disclose no conflict of interest. EDAT- 2026/08/03 12:42 MHDA- 2026/08/03 12:42 CRDT- 2026/08/03 07:32 PHST- 2024/12/17 00:00 [received] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/03 12:42 [medline] PHST- 2026/08/03 12:42 [pubmed] PHST- 2026/08/03 07:32 [entrez] AID - 01209203-990000000-00539 [pii] AID - 10.1097/PTS.0000000000001573 [doi] PST - aheadofprint SO - J Patient Saf. 2026 Aug 3. doi: 10.1097/PTS.0000000000001573. PMID- 42544636 OWN - NLM STAT- Publisher LR - 20260803 IS - 1552-5732 (Electronic) IS - 0890-3344 (Linking) DP - 2026 Aug 3 TI - Adaptation of the IOWA Infant Feeding Attitude Scale Into Turkish for Mothers With Infants Aged 0-12 Months: A Validity and Reliability Study. PG - 8903344261460322 LID - 10.1177/08903344261460322 [doi] AB - BACKGROUND: Mothers' attitudes toward infant feeding are an important factor influencing breastfeeding intention, the initiation of breastfeeding, and the introduction of complementary feeding. AIM: The goal of the study was to culturally adapt the Iowa Infant Feeding Attitude Scale (IIFAS) to Turkish society and to test its validity and reliability. METHODS: This methodological study was conducted on a sample of 304 mothers with infants aged 0-12 months who consented to participate. Data were collected using the Participant Information Form and the Iowa Infant Feeding Attitude Scale. RESULTS: The total variance explained by the IIFAS was 43.966%. Item 1 was left out of further analyses on account of its impact on the scale's Cronbach's alpha value, and Item 17 was excluded due to its failing to meet the factor loading criterion. The chi(2)/df value in the confirmatory factor analysis was 1.745, and the fit indices indicated good model fit (RMSEA = 0.070, GFI = 0.893, CFI = 0.897). The reliability of the scale and subscales was found to be satisfactory. The item-total correlation values were found acceptable as their values range between 0.316 and 0.467. The mean total IIFAS score was 57.32 +/- 7.83. CONCLUSION: The results of the study indicated a neutral attitude score from mothers on the scale. In this regard, nurses ought to design a structured breastfeeding education and counseling intervention for mothers to develop a more positive attitude towards breastfeeding. The IIFAS is a valid tool and can be used to measure the infant feeding attitudes of mothers in Turkey. FAU - Arslan, Nurten AU - Arslan N AUID- ORCID: 0000-0003-1980-5661 AD - Pediatric Nurse, Department of Pediatric Nursing, Faculty of Health Sciences, Zonguldak Bulent Ecevit University, Zonguldak, Turkey. FAU - Kurtuncu, Meltem AU - Kurtuncu M AD - Department of Pediatric Nursing, Faculty of Health Sciences, Zonguldak Bulent Ecevit University, Zonguldak, Turkey. FAU - Gul, Sadiye Gulistan AU - Gul SG AD - Faculty of Health Sciences, Zonguldak Bulent Ecevit University, Zonguldak, Turkey. LA - eng PT - Journal Article DEP - 20260803 PL - United States TA - J Hum Lact JT - Journal of human lactation : official journal of International Lactation Consultant Association JID - 8709498 SB - IM OTO - NOTNLM OT - Bebek Beslenmesi OT - Emzirme OT - Gecerlilik ve Guvenirlik OT - Psikometrik Ozellikler OT - Tutum OT - attitude OT - breastfeeding OT - infant nutrition OT - psychometric properties OT - validity and reliability EDAT- 2026/08/03 12:42 MHDA- 2026/08/03 12:42 CRDT- 2026/08/03 06:52 PHST- 2026/08/03 12:42 [medline] PHST- 2026/08/03 12:42 [pubmed] PHST- 2026/08/03 06:52 [entrez] AID - 10.1177/08903344261460322 [doi] PST - aheadofprint SO - J Hum Lact. 2026 Aug 3:8903344261460322. doi: 10.1177/08903344261460322. PMID- 42544631 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260803 IS - 1118-4841 (Print) IS - 1118-4841 (Linking) VI - 30 IP - 14 DP - 2026 Aug 3 TI - Psychosocial determinants of postpartum blues among matrilineal mothers in West Sumatra, Indonesia. LID - . (Afr J Reprod Health 2026; 30 [14]: 57-65). [pii] LID - 10.29063/ajrh2026/v30i14.7 [doi] AB - Postpartum blues typically occur during the first two weeks after childbirth and may increase the risk of subsequent depressive disorders. In Minangkabau communities of West Sumatra, Indonesia, where matrilineal family systems and neo-local or dual family residence systems exist and husbands frequently migrate, it is insufficiently understood how family structure and partner presence may influence the maternal mood. This study aimed to examine psychosocial determinants of postpartum blues among 240 postpartum mothers between 3 to 14 days postpartum, in Pariaman, West Sumatra, Indonesia. Using a cross-sectional and prospective design, data were collected through face-to-face interviews using validated instruments, including the Pittsburgh Sleep Quality Index (PSQI), Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF), Perceived Stress Scale (PSS-10), and Indonesian Maternal Blues Scale (IMBS). Statistical analysis to identify independent predictors of postpartum blues was performed through descriptive statistics, bivariate analysis, and multivariable logistic regressions. The mean maternal age was 28.6 years old, and 27.9% of participants met the criteria for postpartum blues. Sleep quality was poor for 86.7% of the respondents. The most significant psychosocial determinant of postpartum blues was perceived stress (OR 1.25; 95% CI 1.16-1.34; p < 0.001) and husband migration was borderline significant (OR 2.30; 95% CI 1.00-5.28; p = 0.050). In contrast, sleep quality, breastfeeding self-efficacy, and kin co-residence were not independently associated with postpartum blues. These findings highlight the importance of integrating early psychosocial screening, stress management interventions, and family-centered postpartum support into maternal health policies and primary healthcare services, particularly in culturally unique and migration-affected communities. CI - African Journal of Reproductive Health (c) 2026. FAU - Oktavia, Sesmi N AU - Oktavia SN FAU - Kanathasan, Jayasree S AU - Kanathasan JS LA - eng PT - Journal Article PL - Nigeria TA - Afr J Reprod Health JT - African journal of reproductive health JID - 9712263 SB - IM MH - Humans MH - Female MH - Indonesia/epidemiology MH - Cross-Sectional Studies MH - *Mothers/psychology MH - Adult MH - *Postpartum Period/psychology MH - Prospective Studies MH - *Depression, Postpartum/psychology/epidemiology MH - *Breast Feeding/psychology MH - *Stress, Psychological/psychology/epidemiology MH - Sleep Quality MH - Subjective Stress MH - Young Adult MH - Family Structure MH - Surveys and Questionnaires OTO - NOTNLM OT - Maternal mental health OT - Maternity blues OT - Mothers OT - Perceived stress OT - Postpartum period OT - breastfeeding COIS- The Authors declared no conflict of interest EDAT- 2026/08/03 12:42 MHDA- 2026/08/03 12:43 CRDT- 2026/08/03 06:44 PHST- 2026/08/03 12:43 [medline] PHST- 2026/08/03 12:42 [pubmed] PHST- 2026/08/03 06:44 [entrez] AID - . (Afr J Reprod Health 2026; 30 [14]: 57-65). [pii] AID - 10.29063/ajrh2026/v30i14.7 [doi] PST - ppublish SO - Afr J Reprod Health. 2026 Aug 3;30(14):. (Afr J Reprod Health 2026; 30 [14]: 57-65).. doi: 10.29063/ajrh2026/v30i14.7. PMID- 42544552 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261015 IS - 2153-2176 (Electronic) IS - 2153-2168 (Linking) VI - 22 IP - 8 DP - 2026 Dec TI - Reliability and Repeatability of At-Home Parent-Reported Height and Weight Measurement of Young Children. PG - 479-484 LID - 10.1177/21532176261474683 [doi] AB - Accurate anthropometric measurement is essential for monitoring child growth, yet access to in-person measurement collection can be limited. This study examines the reliability and repeatability of height and weight measurements taken at home by a single parent compared to those taken by a trained researcher team in a clinical setting. Thirty children aged 2-5 years enrolled in the TARGet Kids! cohort were measured by two trained researchers working in a pair and by their parent at home using standardized instructions. Technical error of measurement (TEM), relative TEM (%TEM), and the coefficient of reliability (R) were used to assess measurement reliability. Results demonstrated high reliability and repeatability of parent-reported measurements, particularly for weight. Bland-Altman plots showed slightly greater variation in height measurements collected by the parent at home, though still within acceptable limits. These findings support the use of parent-collected anthropometry at home, which may enhance accessibility for research and clinical care when in-person measurement is not feasible. FAU - Rae, Sarah AU - Rae S AUID- ORCID: 0000-0002-7025-3658 AD - Child Health Evaluative Sciences, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada. AD - Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada. FAU - Keown-Stoneman, Charles AU - Keown-Stoneman C AD - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. AD - Applied Health Research Centre (AHRC), Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, Ontario, Canada. FAU - Pullenayegum, Eleanor AU - Pullenayegum E AD - The Hospital for Sick Children, Toronto, Ontario, Canada. FAU - Ong, Frank AU - Ong F AD - Child Health Evaluative Sciences, The Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, Ontario, Canada. FAU - Dennis, Cindy-Lee AU - Dennis CL AD - Faculty of Nursing, University of Toronto, Toronto, Ontario, Canada. FAU - Hamilton, Jill AU - Hamilton J AD - Division of Endocrinology, The Hospital for Sick Children, Toronto, Ontario, Canada. FAU - Maguire, Jonathon AU - Maguire J AD - Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada. AD - MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, Unity Health Toronto, Division of Paediatrics, St Michael's Hospital, Toronto, Ontario, Canada. FAU - Birken, Catherine S AU - Birken CS AD - Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada. AD - Division of Paediatric Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. LA - eng PT - Journal Article DEP - 20260803 PL - United States TA - Child Obes JT - Childhood obesity (Print) JID - 101542497 SB - IM MH - Humans MH - Child, Preschool MH - Reproducibility of Results MH - *Body Height/physiology MH - Female MH - *Parents MH - Male MH - *Body Weight/physiology MH - *Anthropometry/methods OTO - NOTNLM OT - anthropometric measurement OT - child health OT - early childhood obesity OT - growth monitoring OT - measurement reliability OT - parent-reported data COIS- Author Disclosure StatementNo conflicts of interest to disclose. There are no prior publications or submissions with overlapping information, including studies or participants. EDAT- 2026/08/03 06:36 MHDA- 2026/10/15 07:17 CRDT- 2026/08/03 05:43 PHST- 2026/10/15 07:17 [medline] PHST- 2026/08/03 06:36 [pubmed] PHST- 2026/08/03 05:43 [entrez] AID - 10.1177/21532176261474683 [doi] PST - ppublish SO - Child Obes. 2026 Dec;22(8):479-484. doi: 10.1177/21532176261474683. Epub 2026 Aug 3. PMID- 42544273 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260803 LR - 20260813 IS - 0915-5287 (Print) IS - 2187-5626 (Electronic) IS - 0915-5287 (Linking) VI - 38 IP - 8 DP - 2026 Aug TI - Feasibility of short-term supine rehabilitation for pediatric orthostatic intolerance: a case series. PG - 347-352 LID - 10.1589/jpts.38.347 [doi] AB - [Purpose] This pilot feasibility case series examined the safety, tolerability, and implementability of a short-term inpatient supine exercise program using a low-load bicycle ergometer in pediatric patients with orthostatic intolerance (OI). [Participants and Methods] Four adolescents with OI who had difficulty attending school participated in a 10-13-day inpatient rehabilitation program. The intervention consisted of daily supine ergometer exercise (5-min warm-up, 15-min active pedaling, 5-min cool-down). Feasibility outcomes included completion rate, adherence, and adverse events. Exploratory clinical outcomes included heart rate (HR) response during standing tests, perceived exertion using a 100-mm visual analog scale (VAS), and school attendance two weeks after discharge. [Results] All participants completed the program without adverse events, demonstrating good feasibility and safety. Adherence to supervised sessions was high, and all patients performed self-training. Improvements in perceived exertion were observed in all cases, whereas changes in HR responses were variable. School attendance improved in three patients, although only two were able to attend more than three days per week. [Conclusion] A short-term supine ergometer program appears feasible, safe, and well tolerated in pediatric patients with OI. Given the small sample size, lack of controls, and reliance on subjective outcomes, these findings should be interpreted cautiously. CI - 2026(c)by the Society of Physical Therapy Science. Published by IPEC Inc. FAU - Ohnishi, Takumi AU - Ohnishi T AD - Department of Rehabilitation, Nara Prefectural General Medical Center, Japan. FAU - Mano, Tomoo AU - Mano T AD - Department of Rehabilitation, Nara Prefectural General Medical Center, Japan. AD - Department of Neurology, Nara Medical University: 840 Shijo-cho, Kashihara-shi, Nara 634-8521, Japan. FAU - Nishikawa, Hiroki AU - Nishikawa H AD - Department of Pediatrics, Nara Prefectural General Medical Center, Japan. FAU - Ozaki, Yumi AU - Ozaki Y AD - Department of Rehabilitation, Nara Prefectural General Medical Center, Japan. FAU - Masuda, Takashi AU - Masuda T AD - Department of Rehabilitation, Nara Prefectural General Medical Center, Japan. FAU - Yoshida, Sayaka AU - Yoshida S AD - Department of Pediatrics, Nara Prefectural General Medical Center, Japan. LA - eng PT - Journal Article DEP - 20260801 PL - Japan TA - J Phys Ther Sci JT - Journal of physical therapy science JID - 9105359 PMC - PMC13429274 OTO - NOTNLM OT - Orthostatic intolerance OT - Pediatric rehabilitation OT - Supine exercise COIS- The authors declare no conflicts of interest. EDAT- 2026/08/03 06:36 MHDA- 2026/08/03 06:37 PMCR- 2026/08/01 CRDT- 2026/08/03 03:53 PHST- 2026/03/18 00:00 [received] PHST- 2026/05/24 00:00 [accepted] PHST- 2026/08/03 06:37 [medline] PHST- 2026/08/03 06:36 [pubmed] PHST- 2026/08/03 03:53 [entrez] PHST- 2026/08/01 00:00 [pmc-release] AID - 2026-027 [pii] AID - 10.1589/jpts.38.347 [doi] PST - ppublish SO - J Phys Ther Sci. 2026 Aug;38(8):347-352. doi: 10.1589/jpts.38.347. Epub 2026 Aug 1. PMID- 42542449 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261025 IS - 1476-5640 (Electronic) IS - 0954-3007 (Print) IS - 0954-3007 (Linking) VI - 80 IP - 10 DP - 2026 Oct TI - Segmental BIA-derived body composition in children and adolescents aged 5-18 years: age- and sex-specific reference values and limitations in obesity. PG - 1062-1069 LID - 10.1038/s41430-026-01788-1 [doi] AB - BACKGROUND/OBJECTIVES: Bioimpedance analysis (BIA) is a non-invasive method for estimating fat-free mass (FFM) and fat mass (FM) via resistance (Rz) and reactance (Xc). Despite its potential, its usefulness and accuracy in children remain controversial. SUBJECTS/METHODS: We obtained body composition measurements from 2954 visits involving 1547 participants (aged 5-21 years) using segmental BIA measurements and skinfold-based equations (Slaughter et al.). Four independent analyses were conducted: (1) agreement of Rz and Xc measurements between body segments was assessed; (2) sex- and age-specific reference curves for height-normalized resistance (Rz/H) and reactance (Xc/H) were developed; (3) associations between changes in BMI-SDS, Rz/H, and Xc/H (SDS) were examined; and (4) FM estimates derived from the proprietary algorithm, an alternative formula-based BIA algorithm, and skinfold-based equations were compared with age adjustment. RESULTS: Segmental Rz/H and Xc/H measurements showed "excellent" (>0.9) intraclass correlations for all segments. Concordance correlation coefficients indicated variable agreement between methods. Age- and sex-specific Rz/H and Xc/H percentile curves showed similar progressions across body segments. Rz/H (SDS) and Xc/H (SDS) showed a clear association with BMI-SDS, with lower values in participants with obesity. Estimated FFM and FM showed discrepancies between estimation methods depending on weight status rather than age. CONCLUSION: Rz/H and Xc/H showed consistent age-related patterns but were strongly influenced by BMI-SDS. While agreement between FM estimates was good in normal-weight children, substantial discrepancies were observed in those with obesity. These findings suggest that current BIA-based estimation approaches may be unreliable in children and adolescents with obesity. CI - (c) 2026. The Author(s). FAU - Boker, Klara AU - Boker K AUID- ORCID: 0009-0006-9354-6791 AD - Leipzig University, Medical Faculty, University Hospital for Children and Adolescents Leipzig, Center for Pediatric Research (CPL), LIFE Child, Leipzig, Germany. Klara.Boeker@medizin.uni-leipzig.de. FAU - Vogel, Mandy AU - Vogel M AUID- ORCID: 0000-0003-2051-1249 AD - Leipzig University, Medical Faculty, University Hospital for Children and Adolescents Leipzig, Center for Pediatric Research (CPL), LIFE Child, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig, Germany. FAU - Grundmann, Annelie AU - Grundmann A AD - Leipzig University, Medical Faculty, University Hospital for Children and Adolescents Leipzig, Center for Pediatric Research (CPL), LIFE Child, Leipzig, Germany. FAU - Kiess, Wieland AU - Kiess W AD - Leipzig University, Medical Faculty, University Hospital for Children and Adolescents Leipzig, Center for Pediatric Research (CPL), LIFE Child, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig, Germany. LA - eng PT - Journal Article DEP - 20260801 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 SB - IM MH - Humans MH - Adolescent MH - *Body Composition MH - Child, Preschool MH - Male MH - Reference Values MH - Child MH - *Electric Impedance MH - Female MH - Body Mass Index MH - Skinfold Thickness MH - *Obesity MH - Age Factors MH - Sex Factors MH - Algorithms MH - Young Adult MH - Reproducibility of Results MH - Adipose Tissue PMC - PMC13690603 COIS- Competing interests: The authors declare no competing interests. Ethical approval: The LIFE Child Study was designed in accordance with the Declaration of Helsinki. Approval from the Ethics Committee of the University of Leipzig took place in 2010 (reference number: Reg. No. 264-10-19042010). Fully informed and written consent was obtained from each participant and their parents at each visit to the study outpatient clinic. EDAT- 2026/08/02 00:50 MHDA- 2026/10/23 23:30 PMCR- 2026/08/01 CRDT- 2026/08/01 23:18 PHST- 2025/07/16 00:00 [received] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/06/22 00:00 [revised] PHST- 2026/10/23 23:30 [medline] PHST- 2026/08/02 00:50 [pubmed] PHST- 2026/08/01 23:18 [entrez] PHST- 2026/08/01 00:00 [pmc-release] AID - 10.1038/s41430-026-01788-1 [pii] AID - 1788 [pii] AID - 10.1038/s41430-026-01788-1 [doi] PST - ppublish SO - Eur J Clin Nutr. 2026 Oct;80(10):1062-1069. doi: 10.1038/s41430-026-01788-1. Epub 2026 Aug 1. PMID- 42542448 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261025 IS - 1476-5640 (Electronic) IS - 0954-3007 (Print) IS - 0954-3007 (Linking) VI - 80 IP - 10 DP - 2026 Oct TI - Food selection, cardiorespiratory fitness and the longitudinal association with adiposity among South African school children: the ExAMIN Youth SA study. PG - 1025-1032 LID - 10.1038/s41430-026-01799-y [doi] AB - BACKGROUND: The global pandemic of paediatric obesity, unhealthy diets and physical inactivity are important future health challenges. The purpose of this study was to determine 4-year changes in food selection, cardiorespiratory fitness (CRF), and the longitudinal association with the development of adiposity among South African primary school-age children. METHODS: School children aged 5-9 years old in 2017 (n = 950) were followed up for four years. Parents indicated selection from healthy and unhealthy food groups in a validated questionnaire. Weight and height of the children were measured, and WHO BMI z-score (BAZ) was calculated. CRF was determined by the 20 m shuttle run test (20-m SRT). Changes in food selection frequency, CRF and BAZ were assessed. The association between frequency of food group selection, age, household income and CRF with 4-year change in BAZ was determined using mixed linear models. RESULTS: BAZ (p < 0.001) and age-adjusted performance in the 20-m SRT of boys (p = 0.04) increased at follow-up. The frequency of sugar-sweetened beverages (p < 0.001) and milk intake (p < 0.02) decreased, while the intake from fast-foods increased (p = 0.001). Daily intakes of vegetables and milk were associated with decreases in BAZ. A trend of a positive association was found between frequency of SSB intake and BAZ. CRF showed a strong negative association with BAZ over time (p < 0.001). CONCLUSIONS: Higher daily vegetable and milk intakes, as well as higher levels of CRF were protective against increasing adiposity among school-age children. The promotion of healthy eating and measures to improve CRF among school children are important priorities. CI - (c) 2026. The Author(s). FAU - Kruger, Herculina Salome AU - Kruger HS AUID- ORCID: 0000-0002-5365-1777 AD - Centre of Excellence for Nutrition, North-West University, Potchefstroom, South Africa. salome.kruger@nwu.ac.za. AD - Medical Research Council Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. salome.kruger@nwu.ac.za. FAU - Ricci, Cristian AU - Ricci C AUID- ORCID: 0000-0003-4113-8682 AD - African Unit for Transdisciplinary Health Research, North-West University, Potchefstroom, South Africa. FAU - Pienaar, Anita Elizabeth AU - Pienaar AE AD - Physical Activity, Sport and Recreation Research Focus Area, North-West University, Potchefstroom, South Africa. FAU - Monyeki, Makama Andries AU - Monyeki MA AD - Physical Activity, Sport and Recreation Research Focus Area, North-West University, Potchefstroom, South Africa. FAU - van Zyl, Tertia AU - van Zyl T AD - Centre of Excellence for Nutrition, North-West University, Potchefstroom, South Africa. AD - Medical Research Council Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. FAU - Ricci, Hannah AU - Ricci H AD - African Unit for Transdisciplinary Health Research, North-West University, Potchefstroom, South Africa. FAU - Kruger, Ruan AU - Kruger R AUID- ORCID: 0000-0001-7680-2032 AD - Medical Research Council Research Unit for Hypertension and Cardiovascular Disease, North-West University, Potchefstroom, South Africa. AD - Hypertension in Africa Research Team, North-West University, Potchefstroom, South Africa. LA - eng GR - 86895/South African Medical Research Council (SAMRC)/ PT - Journal Article DEP - 20260801 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 SB - IM MH - Humans MH - Male MH - Child MH - South Africa/epidemiology MH - *Cardiorespiratory Fitness/physiology MH - Female MH - Longitudinal Studies MH - *Adiposity/physiology MH - Child, Preschool MH - *Food Preferences MH - *Diet/statistics & numerical data MH - Body Mass Index MH - *Pediatric Obesity/epidemiology MH - Animals MH - Schools PMC - PMC13690588 COIS- Competing interests: HSK is a member of the Research Grants Panel of the South African Sugar Association and receives an honorarium for the review of grant applications. The South African Sugar Association played no role in the design of the study, collection and analysis of data and the decision to submit this manuscript for publication. The other authors declare no competing interests. Ethical approval: The study protocol was approved by the Centre of Excellence Scientific Review Committee of the North-West University. The researchers obtained approval from the Health Research Ethics Committee (NWU-00091-16-A1) of the North-West University to conduct the study. The parents and caregivers signed informed consent forms for the children while children, whose parents consented, signed assent forms for their participation in the study after they were provided with information about this study and their role and rights as participants. All methods were performed in accordance with the relevant guidelines and regulations. Anthropometry methods were performed according to the International Society for the Advancement of Kinanthropometry protocol. The food group questionnaire data collection was based on validated questionnaire methods. The 20 m shuttle run methods were performed according to published guidelines for the assessment and interpretation of data in relation to youth aerobic fitness and health. EDAT- 2026/08/02 00:50 MHDA- 2026/10/23 23:30 PMCR- 2026/08/01 CRDT- 2026/08/01 23:18 PHST- 2025/08/14 00:00 [received] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/06/26 00:00 [revised] PHST- 2026/10/23 23:30 [medline] PHST- 2026/08/02 00:50 [pubmed] PHST- 2026/08/01 23:18 [entrez] PHST- 2026/08/01 00:00 [pmc-release] AID - 10.1038/s41430-026-01799-y [pii] AID - 1799 [pii] AID - 10.1038/s41430-026-01799-y [doi] PST - ppublish SO - Eur J Clin Nutr. 2026 Oct;80(10):1025-1032. doi: 10.1038/s41430-026-01799-y. Epub 2026 Aug 1. PMID- 42542003 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20260916 IS - 1878-0334 (Electronic) IS - 1871-4021 (Linking) VI - 20 IP - 7 DP - 2026 Jul TI - Body shape index and body roundness index: Novel anthropometric indices to identify diabetes mellitus among the Indian population. PG - 103468 LID - S1871-4021(26)00095-0 [pii] LID - 10.1016/j.dsx.2026.103468 [doi] AB - AIMS: We aimed to compare the discriminatory performance of Body Shape Index and Body Roundness Index with traditional anthropometric measures, including body mass index, waist circumference, and waist-to-height ratio, for identifying prevalent diabetes among Indian adults. METHODS: Data from the fifth round of the National Family Health Survey were analyzed, including 574,099 women and 74,761 men (aged 15-49 years). Diabetes was defined by self-reported diagnosis, current use of glucose-lowering medication, or a random blood glucose >/=200 mg/dL. Anthropometric indices were derived from measured height, weight, and waist circumference. Survey-weighted prevalence estimates, multivariable logistic regression, receiver operating characteristic analysis, DeLong tests, and trend tests were used. RESULTS: The weighted prevalence of diabetes was 13.6% and increased with age, urban residence, higher wealth, education, obesity, and hypertension. Waist circumference showed the highest correlation with diabetes (r = 0.1446) and the highest, though modest, discrimination (area under the curve = 0.61). Body mass index, Body Roundness Index, and waist-to-height ratio performed similarly (area under the curve = 0.60 each), whereas Body Shape Index showed the lowest discrimination (area under the curve = 0.55). DeLong comparisons showed that waist circumference and Body Roundness Index performed significantly better than Body Shape Index, while Body Roundness Index showed no meaningful incremental discrimination beyond waist-to-height ratio. CONCLUSIONS: Waist circumference, waist-to-height ratio, and Body Roundness Index performed similarly to, and modestly better than, the Body Shape Index for identifying prevalent diabetes in Indian adults. Simpler waist-based measures, particularly waist circumference and waist-to-height ratio, may be sufficient for population-level diabetes risk screening. CI - Copyright (c) 2026 Research Trust of DiabetesIndia (DiabetesIndia) and National Diabetes Obesity and Cholesterol Foundation (N-DOC). Published by Elsevier Ltd. All rights reserved. FAU - Verma, Madhur AU - Verma M AD - Community and Family Medicine, All India Institute of Medical Sciences, Bathinda, India. Electronic address: drmadhurverma@gmail.com. FAU - Halder, Pritam AU - Halder P AD - Department of Community Medicine, School of Public Halth, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Electronic address: rynedann@gmail.com. FAU - Jeer, Girish AU - Jeer G AD - Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India. Electronic address: drgirish.jeer@gmail.com. FAU - Kapoor, Nitin AU - Kapoor N AD - Endocrinology, Dept. of Endocrine, Diabetes and Metabolism, Christian Medical College, Vellore, TN, 632004, India; Non-communicable Disease Unit, The Baker Heart and Diabetes Institute, Melbourne, Victoria, 3004, Australia. Electronic address: nitin.endocrine@gmail.com. FAU - Kochhar, Sonia AU - Kochhar S AD - Physiology, All India Institute of Medical Sciences Bathinda, India. Electronic address: kochhar.sonia.dr@gmail.com. FAU - Prabha, Indu AU - Prabha I AD - Community and Family Medicine, All India Institute of Medical Sciences, Bathinda, India. Electronic address: prabhaindu01@gmail.com. FAU - Kakkar, Rakesh AU - Kakkar R AD - Community & Family Medicine, All India Institute of Medical Sciences, Bathinda, 151001, India. Electronic address: drrakesh75@rediffmail.com. FAU - Kalra, Sanjay AU - Kalra S AD - Endocrinology, Bharti Hospital, Karnal, Haryana, India; University Centre for Research and Development, Chandigarh University, Mohali, India. Electronic address: brideknl@gmail.com. LA - eng PT - Journal Article DEP - 20260728 PL - Netherlands TA - Diabetes Metab Syndr JT - Diabetes & metabolic syndrome JID - 101462250 SB - IM MH - Humans MH - Male MH - Middle Aged MH - Adult MH - India/epidemiology MH - Female MH - *Diabetes Mellitus/epidemiology/diagnosis MH - *Body Mass Index MH - Adolescent MH - *Waist Circumference MH - Young Adult MH - *Waist-Height Ratio MH - Prognosis MH - Prevalence MH - Follow-Up Studies MH - *Anthropometry MH - Cross-Sectional Studies MH - Risk Factors MH - *Obesity/epidemiology OTO - NOTNLM OT - Anthropometric measures OT - Barophenotype OT - Body roundness index OT - Body shape index OT - Diabetes mellitus OT - India OT - National family health survey OT - Obesity COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/02 00:50 MHDA- 2026/09/16 23:34 CRDT- 2026/08/01 18:06 PHST- 2025/08/06 00:00 [received] PHST- 2026/07/24 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/09/16 23:34 [medline] PHST- 2026/08/02 00:50 [pubmed] PHST- 2026/08/01 18:06 [entrez] AID - S1871-4021(26)00095-0 [pii] AID - 10.1016/j.dsx.2026.103468 [doi] PST - ppublish SO - Diabetes Metab Syndr. 2026 Jul;20(7):103468. doi: 10.1016/j.dsx.2026.103468. Epub 2026 Jul 28. PMID- 42541538 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261014 IS - 1437-1596 (Electronic) IS - 0937-9827 (Linking) VI - 140 IP - 6 DP - 2026 Nov TI - Mandibular condylar cortication and third molar apical closure on cone beam computed tomography for the assessment of legal adulthood: a pilot retrospective study. PG - 4289-4297 LID - 10.1007/s00414-026-03932-9 [doi] AB - INTRODUCTION: Accurate estimation of legal adulthood in undocumented individuals remains a major challenge in forensic and medico-legal contexts. This study evaluates mandibular condylar cortication and third molar apical closure assessed by cone beam computed tomography (CBCT) as potential indicators of age of majority. A retrospective observational pilot study was conducted on 142 individuals aged 13-25 years from six geographic regions (Spain, Uruguay, Peru, Mexico, Venezuela and Colombia). Two radiological variables were analyzed: the presence of cortical bone in the mandibular condyle and apical closure of the mandibular third molars. Associations with chronological age were explored descriptively, considering sex and geographic origin. RESULTS: Mandibular condylar cortication was identified exclusively in individuals aged 18 years or older. It showed 89.2% sensitivity, 100% specificity, 100% positive predictive value, and 89.5% negative predictive value for identifying legal adulthood. Complete third molar apical closure showed lower sensitivity (64.7%) and specificity of 96.6%. Both markers were significantly associated with legal adulthood (Fisher's exact test, p < 0.001). CONCLUSION: Within the limitations of this pilot study, mandibular condylar cortication assessed by CBCT appears to be a promising indicator of legal adulthood, potentially offering higher specificity than third molar apical closure. Further large-scale studies are required to validate these findings. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Martinez-Mirave, Araceli P AU - Martinez-Mirave AP AD - Faculty of Dentistry, UIC Barcelona, Sant Cugat del Valles, Barcelona, Spain. FAU - Abecasis, Pedro Maria AU - Abecasis PM AD - IUEM - Instituto Universitario Egas Moniz, Lisbon, Portugal. FAU - Jaureguy, Santiago Andres AU - Jaureguy SA AD - Faculty of Dentistry, UIC Barcelona, Sant Cugat del Valles, Barcelona, Spain. FAU - Satorres-Nieto, Marta AU - Satorres-Nieto M AD - Faculty of Dentistry, UIC Barcelona, Sant Cugat del Valles, Barcelona, Spain. msatorres@uic.es. LA - eng PT - Journal Article PT - Observational Study DEP - 20260801 PL - Germany TA - Int J Legal Med JT - International journal of legal medicine JID - 9101456 SB - IM MH - Humans MH - *Cone-Beam Computed Tomography MH - Pilot Projects MH - Retrospective Studies MH - Male MH - Adult MH - Young Adult MH - Female MH - Adolescent MH - *Molar, Third/diagnostic imaging/growth & development MH - *Mandibular Condyle/diagnostic imaging/growth & development MH - *Age Determination by Teeth/methods MH - Sensitivity and Specificity MH - *Cortical Bone/diagnostic imaging MH - *Tooth Apex/diagnostic imaging/growth & development OTO - NOTNLM OT - Age estimation OT - CBCT OT - Cortication OT - Forensic dentistry OT - Mandibular condyle OT - Third molar COIS- Declarations. Ethics: This retrospective study was conducted in accordance with the principles of the Declaration of Helsinki. All CBCT scans were anonymized prior to analysis. Ethics approval: This study (Study Code: REC-ECL-2025-01) was approved by the Ethics Committee of the Clinica Universitaria d'Odontologia (CEIm), UIC Barcelona (Acta 8AG, approval date 09/04/2025). Consent to participate: The requirement for informed consent was waived due to the retrospective nature of the study and the use of anonymized CBCT images. The study protocol, including the request for waiver of informed consent, was reviewed and approved by the Ethics Committee. Clinical trial number: Not applicable. AI statement: The authors declare that artificial intelligence (AI) tools were used solely to assist in language refinement and improvement of manuscript clarity. All scientific content, study design, data analysis, and interpretation of results were performed by the authors. The authors take full responsibility for the accuracy and integrity of the work. Competing interests: The authors declare no competing interests. EDAT- 2026/08/02 00:30 MHDA- 2026/10/12 17:30 CRDT- 2026/08/01 11:13 PHST- 2026/06/05 00:00 [received] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/10/12 17:30 [medline] PHST- 2026/08/02 00:30 [pubmed] PHST- 2026/08/01 11:13 [entrez] AID - 10.1007/s00414-026-03932-9 [pii] AID - 10.1007/s00414-026-03932-9 [doi] PST - ppublish SO - Int J Legal Med. 2026 Nov;140(6):4289-4297. doi: 10.1007/s00414-026-03932-9. Epub 2026 Aug 1. PMID- 42540724 OWN - NLM STAT- MEDLINE DCOM- 20260801 LR - 20260813 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Criterion validity assessment of the 24-hour movement behaviors questionnaire (24HMBQ) for Chinese college students: validation study. PG - e21490 LID - 10.7717/peerj.21490 [doi] LID - e21490 AB - BACKGROUND: Accumulating studies have investigated the combined effects of 24-h movement behaviors on physical and mental health. The 24-hour Movement Behaviors Questionnaire (24HMBQ) was recently developed to measure the 24-hour movement behaviors in college students. However, its criterion validity remains to be elucidated. This study aimed to investigate the criterion validity of the 24HMBQ against accelerometer-derived data among Chinese college students. METHODS: Eighty-eight college students (age = 20.2 +/- 2.2 years) participated in this study. The Axivity AX3 accelerometers were used to objectively measure physical activity (PA), sedentary behavior (SB), and sleep levels over a consecutive seven-day period. At the last day, participants completed the 24HMBQ to self-report their PA, SB, and sleep levels. Paired-sample t-test, Spearman's rank correlation test, and Bland-Altman plot were used to examine the degree of agreement between 24HMBQ and accelerometer data. RESULTS: Spearman's correlation coefficients indicated strong agreement for sleep metrics (Rho = 0.77, p < 0.001 for weekdays; Rho = 0.68, p < 0.001 for weekends) and moderate agreement for SB (Rho = 0.55, p < 0.001 for weekdays; Rho = 0.33, p < 0.01 for weekends) between 24HMBQ and accelerometer measurements. However, lower correlations were observed for physical activities including light PA (Rho = 0.30, p < 0.01) and moderate-to-vigorous PA (MVPA; Rho = 0.15, p > 0.05). CONCLUSION: The 24HMBQ showed good criterion validity for sleep and moderate validity for sedentary behavior, but limited validity for physical activity (especially MVPA). CI - (c)2026 Tan et al. FAU - Tan, Teck Cheng AU - Tan TC AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Zheng, Jiaxin AU - Zheng J AD - School of Physical Education and Sport Science, Fujian Normal University, Fuzhou, China. FAU - Chen, Tianle AU - Chen T AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China. FAU - Liu, Yiting AU - Liu Y AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China. FAU - Luo, Yan AU - Luo Y AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China. FAU - Yang, Yanxiang AU - Yang Y AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China. FAU - Huang, Tao AU - Huang T AD - Department of Physical Education, Shanghai Jiao Tong University, Shanghai, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260728 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - Female MH - *Students/statistics & numerical data MH - Surveys and Questionnaires/standards MH - Young Adult MH - *Exercise MH - Male MH - Accelerometry MH - Universities MH - Reproducibility of Results MH - *Sedentary Behavior MH - Sleep MH - China MH - Sleep Duration MH - Adolescent PMC - PMC13426337 OTO - NOTNLM OT - 24-hour movement behavior OT - Accelerometer OT - College students OT - Criterion validity OT - Questionnaire COIS- The authors declare there are no competing interests. EDAT- 2026/08/02 00:30 MHDA- 2026/08/02 00:31 PMCR- 2026/07/28 CRDT- 2026/08/01 06:42 PHST- 2025/12/15 00:00 [received] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/08/02 00:31 [medline] PHST- 2026/08/02 00:30 [pubmed] PHST- 2026/08/01 06:42 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - 21490 [pii] AID - 10.7717/peerj.21490 [doi] PST - epublish SO - PeerJ. 2026 Jul 28;14:e21490. doi: 10.7717/peerj.21490. eCollection 2026. PMID- 42539487 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260801 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Physical literacy and mental well-being in adults: a cross-sectional examination of their association and links with physical activity engagement. PG - 1908692 LID - 10.3389/fpsyg.2026.1908692 [doi] LID - 1908692 AB - BACKGROUND: Physical literacy, the integrated motivation, confidence, physical competence, knowledge, and understanding that underpins lifelong physical activity, has been advanced as a holistic determinant of health. Yet, evidence linking it to positively framed mental well-being in adults remains scarce and is dominated by samples of children and adolescents. AIM: This study examined the association between physical literacy and mental well-being in Turkish adults and tested whether both constructs differed by sex, educational attainment, athletic background, regular exercise participation, and habitual physical activity level. METHODS: In a cross-sectional design, 375 adults (64.5% male; mean age = 32.23 years, SD = 11.03, range 18-71), a convenience sample skewed toward physically active and tertiary-educated men, completed validated Turkish measures of physical literacy and mental well-being. Active-living exposures were assessed using a single self-report item. Internal consistency was high (physical literacy alpha = 0.89, omega = 0.90; mental well-being alpha = 0.92, omega = 0.92). Pearson correlations, t-tests, one-way ANOVAs, and hierarchical regression were computed with effect sizes and 95% confidence intervals; discriminant validity was tested directly, and an exploratory mediation was examined. RESULTS: Physical literacy was moderately and positively associated with mental well-being (r = 0.45, p < 0.001), and the two constructs showed evidence of empirical distinctness (HTMT = 0.52, 95% CI [0.42, 0.63]). Adults with an athletic background and regular exercisers reported higher physical literacy (d = 0.83 and 1.09) and mental well-being (d = 0.36 and 0.63), and both outcomes increased in an ordered gradient across habitual activity-frequency categories (physical literacy eta(2) = 0.21; mental well-being eta(2) = 0.07). Physical literacy explained 11% of incremental variance in well-being beyond demographic and behavioral covariates (beta = 0.41). Men scored marginally higher than women on both measures, educational attainment was weakly related to mental well-being but not physical literacy, and physical literacy declined modestly with age (r = -0.18). CONCLUSION: Higher physical literacy co-occurs with better mental well-being in adults and remains associated with mental well-being after adjustment for covariates, positioning it as a candidate target for adult mental health promotion. The cross-sectional design and active, educated convenience sample preclude causal and population-level inference, and independent confirmatory validation of the adapted instrument is needed before these findings are treated as more than provisional. CI - Copyright (c) 2026 Orhan, Alkasasbeh, Karacam, Branquinho and Amawi. FAU - Orhan, Bekir Erhan AU - Orhan BE AD - Faculty of Sports Sciences, Istanbul Aydin University, Istanbul, Turkiye. FAU - Alkasasbeh, Walaa Jumah AU - Alkasasbeh WJ AD - Department of Physical Education, Faculty of Sport Science, The University of Jordan, Amman, Jordan. FAU - Karacam, Aydin AU - Karacam A AD - Faculty of Sport Sciences, Bandirma Onyedi Eylul University, Balikesir, Turkiye. FAU - Branquinho, Luis AU - Branquinho L AD - Biosciences School of Elvas, Polytechnic University of Portalegre, Elvas, Portugal. AD - Life Quality Research Center (LQRC-CIEQV), Santarem, Portugal. AD - Research Center in Sports Sciences, Health Sciences and Human Development, Covilha, Portugal. AD - Centro De Investigacao Do Instituto Superior De Ciencia Educativas (CI-ISCE), Penafiel, Portugal. FAU - Amawi, Adam Tawfiq AU - Amawi AT AD - Department of Movement Sciences and Sports Training, School of Sports Science, The University of Jordan, Amman, Jordan. LA - eng PT - Journal Article DEP - 20260717 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13423689 OTO - NOTNLM OT - health promotion OT - mental well-being OT - physical activity OT - physical literacy OT - self-determination theory OT - sustainable health COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer AR declared a past collaboration with the authors BO and LB to the handling editor. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/08/02 00:30 MHDA- 2026/08/02 00:31 PMCR- 2026/07/17 CRDT- 2026/08/01 06:07 PHST- 2026/06/14 00:00 [received] PHST- 2026/06/22 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/08/02 00:31 [medline] PHST- 2026/08/02 00:30 [pubmed] PHST- 2026/08/01 06:07 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1908692 [doi] PST - epublish SO - Front Psychol. 2026 Jul 17;17:1908692. doi: 10.3389/fpsyg.2026.1908692. eCollection 2026. PMID- 42539320 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260801 LR - 20260813 IS - 2688-4844 (Electronic) IS - 2688-4844 (Linking) VI - 7 DP - 2026 Jan-Dec TI - Obesity among Obstetrical Patients Seeking Care in a Safety Net Hospital: The Impact of Adverse Childhood Events. PG - 26884844261445331 LID - 10.1177/26884844261445331 [doi] LID - 26884844261445331 AB - OBJECTIVE: To determine the prevalence of obesity among a cohort of pregnant patients with high compared with low adverse childhood events scores. STUDY DESIGN DESCRIPTIVE STUDY METHODS: The study was part of a large study of adverse childhood events among pregnant women seeking care in a safety net hospital from June 2022 to June 2023. The patients were seen in a variety of settings (a routine prenatal clinic, a high-risk clinic, an antepartum testing unit, an obstetrical ultrasound unit, and a labor and delivery suite). They were randomly approached and asked to complete a previously validated questionnaire for their Adverse Childhood Experience score (ACE score). Their body mass index (BMI) on their first visit was recorded. BMI was categorized as overweight (BMI > 25), class I obesity (BMI > 30), class II obesity (BMI > 35), and class III obesity (BMI > 40). This study was approved by the Valleywise Institutional Review Board. RESULTS: Three hundred and forty-nine patients were approached and 320 agreed to complete the questionnaire. Eighty percent of patients had an initial prenatal visit BMI >25 and 62% had an initial BMI that was categorized as obese. Patients with a high ACEs score were more likely to have a BMI in the obese category compared with those in the low-risk group with an odds ratio of 1.34 (95% CI [0.7907-2.2798], p = 0.275). CONCLUSION: Maternal obesity is a well-known risk factor for numerous adverse obstetrical and neonatal outcomes. While the CDC reported a national prepregnancy obesity rate of 29.0% in 2019, our patients were 2.14 times more likely to be obese. Obesity was more prevalent in women with high ACEs scores. Safety net hospitals should be cognizant of marked increase in obesity in their obstetrical patients, especially those with high ACEs scores, and develop interventions that incorporate trauma-informed care. CI - (c) The Author(s) 2026. Published by Mary Ann Liebert (NY), LLC. FAU - Goforth, Michelle AU - Goforth M AD - University of Arizona College of Medicine, Phoenix, Arizona, USA. FAU - Brady, Sarah R AU - Brady SR AD - University of Arizona College of Medicine, Phoenix, Arizona, USA. FAU - Chambliss, Linda R AU - Chambliss LR AUID- ORCID: 0000-0003-1518-9240 AD - University of Arizona College of Medicine, Phoenix, Arizona, USA. AD - Department of Obstetrics and Gynecology, Creighton University School of Medicine, Phoenix Regional Campus, Nebraska, USA. AD - Department of Obstetrics and Gynecology, Valleywise Health Center, Phoenix, Arizona, USA. LA - eng PT - Journal Article DEP - 20260531 PL - United States TA - Womens Health Rep (New Rochelle) JT - Women's health reports (New Rochelle, N.Y.) JID - 101768931 PMC - PMC13421971 OTO - NOTNLM OT - ACES score OT - adverse childhood events OT - childhood trauma OT - obesity OT - pregnancy COIS- No competing financial interests exist. EDAT- 2026/08/01 06:35 MHDA- 2026/08/01 06:36 PMCR- 2026/05/31 CRDT- 2026/08/01 06:01 PHST- 2025/12/04 00:00 [accepted] PHST- 2026/08/01 06:36 [medline] PHST- 2026/08/01 06:35 [pubmed] PHST- 2026/08/01 06:01 [entrez] PHST- 2026/05/31 00:00 [pmc-release] AID - 10.1177_26884844261445331 [pii] AID - 10.1177/26884844261445331 [doi] PST - epublish SO - Womens Health Rep (New Rochelle). 2026 May 31;7:26884844261445331. doi: 10.1177/26884844261445331. eCollection 2026 Jan-Dec. PMID- 42538742 OWN - NLM STAT- MEDLINE DCOM- 20260801 LR - 20260813 IS - 2090-2735 (Electronic) IS - 2090-2727 (Print) IS - 2090-2727 (Linking) VI - 2026 IP - 1 DP - 2026 TI - Associations Between Potential Listeria monocytogenes Exposure During Pregnancy and Infant Outcomes at Birth and Infant Delivery Resource Use: A Cross-Sectional Analysis in Australian Women. PG - e7824916 LID - 10.1155/jp/7824916 [doi] LID - 7824916 AB - Pregnant women are at higher risk of contracting listeriosis, which can lead to serious perinatal complications. This study evaluated associations between Listeria monocytogenes exposure, infant perinatal outcomes, and hospital resource use in a cohort of 1604 Australian mother-infant dyads. Maternal L. monocytogenes exposure was estimated from self-reported intake of foods from a validated food frequency questionnaire that potentially harbor L. monocytogenes. Infant outcomes obtained from hospital medical records included birth mode, preterm birth, birthweight, and admission to special care nursery (SCN)/neonatal intensive care unit (NICU). Infant hospital resource use was measured by infant length of stay (LOS), LOS in SCN/NICU, and days excluding SCN/NICU. Multinomial, negative binomial, and hurdle models, were performed to examine Listeria Food Exposure Score (LFES) associations with infant outcomes, total LOS, and LOS excluding and within SCN/NICU. All models were adjusted for covariates including smoking, parity, maternal age, BMI, and SEIFA IRSAD decile. Mean (SD) maternal age was 32.0 (5.0) years, and median (IQR) gestation was 39.0 (38.1, 40.0) weeks. Although adjusted results showed a statistically significant association between LFES and reduced infant LOS excluding SCN/NICU (beta = 0.99; 95% CI: 0.979, 0.998, p < 0.03), the effect size was minimal, with minor clinical significance. There were no significant associations with infant birth mode, preterm birth, low birthweight, size for gestational age, macrosomia, admission to NICU/SCN, total LOS in hospital, and SCN/NICU (all p > 0.05). Future research should explore these associations among ethnically diverse women at earlier stage of pregnancy and include the assessment of food safety practices in the analyses. CI - Copyright (c) 2026 Kee June Ooi et al. Journal of Pregnancy published by John Wiley & Sons Ltd. FAU - Ooi, Kee June AU - Ooi KJ AUID- ORCID: 0000-0002-1564-9799 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia, ncl.ac.uk. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, hmri.com.au. FAU - Fenton, Sasha AU - Fenton S AUID- ORCID: 0000-0002-4611-5810 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia, ncl.ac.uk. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, hmri.com.au. FAU - Taylor, Rachael AU - Taylor R AUID- ORCID: 0000-0002-1895-4123 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia, ncl.ac.uk. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, hmri.com.au. FAU - Hinwood, Madeleine AU - Hinwood M AUID- ORCID: 0000-0002-2225-973X AD - Data Science, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, hmri.com.au. AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia, ncl.ac.uk. FAU - Pannu, Poonam Kaur AU - Pannu PK AUID- ORCID: 0009-0006-0724-4683 AD - The Kids Research Institute Australia, Nedlands, Western Australia, Australia. AD - Curtin University, Bentley, Western Australia, Australia, curtin.edu.au. FAU - Hutchesson, Melinda AU - Hutchesson M AUID- ORCID: 0000-0002-1851-0661 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia, ncl.ac.uk. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, hmri.com.au. FAU - Collins, Clare E AU - Collins CE AUID- ORCID: 0000-0003-3298-756X AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia, ncl.ac.uk. AD - Nutrition and Metabolic Health Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia, hmri.com.au. LA - eng GR - Commonwealth Government of Australia/ GR - Paul Ramsay Foundation/ GR - Joondalup Health Campus/ GR - Telethon Perth Children's Hospital Research Fund/ GR - Hunter Medical Research Institute/ GR - APP2009340/National Health and Medical Research Council/ PT - Journal Article PL - United States TA - J Pregnancy JT - Journal of pregnancy JID - 101553823 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Infant, Newborn MH - Adult MH - Cross-Sectional Studies MH - *Listeria monocytogenes MH - Australia/epidemiology MH - *Listeriosis/epidemiology MH - *Pregnancy Complications, Infectious/epidemiology/microbiology MH - Pregnancy Outcome/epidemiology MH - Premature Birth/epidemiology MH - Length of Stay/statistics & numerical data MH - Intensive Care Units, Neonatal/statistics & numerical data MH - Birth Weight PMC - PMC13428182 OTO - NOTNLM OT - Listeria monocytogenes OT - ORIGINS OT - birth outcomes OT - hospital resource use OT - infant outcomes OT - listeriosis COIS- The authors declare no conflicts of interest. EDAT- 2026/08/01 06:35 MHDA- 2026/08/01 06:36 PMCR- 2026/07/31 CRDT- 2026/08/01 02:02 PHST- 2026/02/18 00:00 [revised] PHST- 2025/04/08 00:00 [received] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/08/01 06:36 [medline] PHST- 2026/08/01 06:35 [pubmed] PHST- 2026/08/01 02:02 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - JP7824916 [pii] AID - 10.1155/jp/7824916 [doi] PST - ppublish SO - J Pregnancy. 2026;2026(1):e7824916. doi: 10.1155/jp/7824916. PMID- 42538677 OWN - NLM STAT- MEDLINE DCOM- 20260801 LR - 20260801 IS - 2146-8427 (Electronic) IS - 1304-0855 (Linking) VI - 24 IP - Suppl 2 DP - 2026 Jul TI - Preoperative Nutritional Indices Predicting Delayed Graft Function in Pediatric Kidney Transplantation. PG - 177-182 LID - 10.6002/ect.MESOT2025.O61 [doi] AB - OBJECTIVES: The Prognostic Nutritional Index, which combines serum albumin and lymphocyte count, captures protein reserves and immune competence in a single, easily obtained metric. Whether this index can predict delayed graft function among pediatric kidney transplant recipients has not been thoroughly evaluated. Here, we examined whether use of this index pretransplant can predict delayed graft function in this population. MATERIALS AND METHODS: We reviewed children (aged 1 -18 years )who received kidney transplants at Baskent University Hospital from January 2013 to December 2024. Patients were stratified by delayed graft function status. We collected recipient and donor demographics, clinical characteristics, and routine preoperative laboratory values. The Prognostic Nutritional Index and other inflammatory indices (neutrophil -to -lymphocyte ratio, platelet -to -lymphocyte ratio, and systemic inflammatory index derived from the same preoperative blood counts ) were calculated. RESULTS: Twenty -eight of 162 children (17.3 % ) experienced delayed graft function. In regression analysis, each 1 -point increase in the Prognostic Nutritional Index, which reflects better nutritional and immune status, was linked to an 8 % lower chance of developing delayed graft function (odds ratio 0.92; 95 % CI, 0.85 -0.99; P = .042 ). Higher neutrophil -to -lymphocyte ratio indicated significantly greater risk of delayed graft function (odds ratio 1.30; 95 % CI, 1.05 -1.61; P = .016 ), and a 1 -unit rise in the platelet -to -lymphocyte ratio provided a small but meaningful protective effect (odds ratio 0.99; 95 % CI, 0.993 -0.999; P = .041 ). Higher systemic inflammatory index indicated a slightly lower risk of delayed graft function (odds ratio 0.9997 /unit increase; P =.049 ). Recipient characteristics did not differ between those with and without delayed graft function. CONCLUSIONS: Among the study patients, the Prognostic Nutritional Index emerged as a strong predictor of delayed graft function. Integrating this index with simple inflammatory indices into preoperative assessments may enable early identification of high -risk children, inform donor selection, and guide perioperative management to improve graft outcomes. FAU - Siddiqui, Meraj Alam AU - Siddiqui MA AD - From the Department of Pediatrics,Baskent University Faculty of Medicine, Ankara, Turkiye, and Lister Hospital, East and North Hertfordshire Teaching NHS Trust, United Kingdom. FAU - Baskin, Esra AU - Baskin E FAU - Aksoy, Ozlem Yuksel AU - Aksoy OY FAU - Akdeniz, Alara AU - Akdeniz A FAU - Okyay, Ozan AU - Okyay O FAU - Safak, Adem AU - Safak A FAU - Karakaya, Emre AU - Karakaya E FAU - Haberal, Mehmet AU - Haberal M LA - eng PT - Journal Article PL - Turkey TA - Exp Clin Transplant JT - Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation JID - 101207333 RN - 0 (Biomarkers) RN - ZIF514RVZR (Serum Albumin, Human) RN - 0 (ALB protein, human) SB - IM MH - Humans MH - *Kidney Transplantation/adverse effects MH - Female MH - *Delayed Graft Function/diagnosis/etiology/physiopathology MH - *Nutritional Status MH - Child, Preschool MH - Child MH - Male MH - Risk Factors MH - *Nutrition Assessment MH - Infant MH - Predictive Value of Tests MH - Time Factors MH - Adolescent MH - Retrospective Studies MH - Treatment Outcome MH - Risk Assessment MH - Biomarkers/blood MH - Age Factors MH - Lymphocyte Count MH - *Serum Albumin, Human/analysis MH - Turkey MH - Graft Survival EDAT- 2026/08/01 06:35 MHDA- 2026/08/01 06:36 CRDT- 2026/08/01 01:03 PHST- 2026/08/01 06:36 [medline] PHST- 2026/08/01 06:35 [pubmed] PHST- 2026/08/01 01:03 [entrez] AID - 10.6002/ect.MESOT2025.O61 [doi] PST - ppublish SO - Exp Clin Transplant. 2026 Jul;24(Suppl 2):177-182. doi: 10.6002/ect.MESOT2025.O61. PMID- 42538110 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260821 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 7 DP - 2026 Jul 31 TI - Non-pharmacological interventions for lactational mastitis: a systematic review and meta-analysis protocol. PG - e120579 LID - 10.1136/bmjopen-2026-120579 [doi] LID - e120579 AB - BACKGROUND: Lactational mastitis is a common inflammatory condition that can adversely affect maternal well-being and is associated with early cessation of breastfeeding. Although antibiotics and analgesics are widely used in clinical practice, concerns regarding antimicrobial resistance and potential effects on the infant microbiome have prompted increasing interest in non-pharmacological approaches. A range of physical and biological interventions, including probiotics, therapeutic ultrasound, acupuncture and manual therapies, have been investigated; however, the comparative effectiveness and safety of these interventions remain unclear. This study aims to systematically evaluate the efficacy and safety of non-pharmacological interventions for lactational mastitis. METHODS AND ANALYSIS: This protocol is reported in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) guidelines. We will systematically search PubMed, Embase, Web of Science, the Cochrane Library, CNKI, Wanfang, VIP and SinoMed as well as relevant trial registries from database inception to March 2026.We will include randomised controlled trials enrolling adult lactating women diagnosed with mastitis. Eligible studies will compare non-pharmacological interventions with usual care, placebo or pharmacological treatments. Interventions involving pharmacologically active agents will be excluded.Two reviewers will independently perform study selection, data extraction and risk of bias assessment using the Cochrane RoB 2 tool. The primary outcome will be resolution of mastitis, defined as the return of body temperature to normal (<37 degrees C) and resolution of localised breast symptoms (eg, pain, erythema and swelling). Secondary outcomes will include inflammatory markers (eg, C-reactive protein), pain intensity (measured using the Visual Analogue Scale or similar validated scales), incidence of adverse events, complete blood count parameters, time to symptom resolution or normalisation of body temperature, incidence of breast abscess and breastfeeding continuation rates.Meta-analysis will be conducted, where appropriate, using random-effects models. Continuous outcomes will be summarised using mean differences or standardised mean differences, and dichotomous outcomes using risk ratios, all with 95% CIs. Statistical heterogeneity will be assessed using the I(2) statistic. Subgroup and sensitivity analyses will be performed to explore potential sources of heterogeneity. Publication bias will be assessed using funnel plots and Egger's test when sufficient studies are available. The certainty of evidence will be evaluated using the Grading of Recommendations Assessment, Development and Evaluation（GRADE）approach. ETHICS AND DISSEMINATION: Ethical approval is not required for this study as it is based on published data. The findings will be disseminated through peer-reviewed publications and conference presentations. PROSPERO REGISTRATION NUMBER: CRD420261347640. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Zhang, Siyuan AU - Zhang S AUID- ORCID: 0009-0003-8378-2887 AD - Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. FAU - Ren, Yuehan AU - Ren Y AUID- ORCID: 0009-0008-7225-2908 AD - Graduate School, Beijing University of Chinese Medicine, Beijing, China. FAU - Zhang, Qiong AU - Zhang Q AD - Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. FAU - Fan, Yingyi AU - Fan Y AD - Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing, China fan38898901@126.com. LA - eng PT - Journal Article DEP - 20260731 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Female MH - *Mastitis/therapy MH - Systematic Reviews as Topic MH - *Lactation MH - Meta-Analysis as Topic MH - Breast Feeding MH - Research Design MH - Probiotics/therapeutic use MH - Acupuncture Therapy PMC - PMC13436078 OTO - NOTNLM OT - Breast surgery OT - Meta-Analysis OT - Protocols & guidelines OT - Systematic Review COIS- Competing interests: None declared. EDAT- 2026/08/01 00:36 MHDA- 2026/08/01 00:37 PMCR- 2026/07/31 CRDT- 2026/07/31 21:03 PHST- 2026/08/01 00:37 [medline] PHST- 2026/08/01 00:36 [pubmed] PHST- 2026/07/31 21:03 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - bmjopen-2026-120579 [pii] AID - 10.1136/bmjopen-2026-120579 [doi] PST - epublish SO - BMJ Open. 2026 Jul 31;16(7):e120579. doi: 10.1136/bmjopen-2026-120579. PMID- 42537543 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260825 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 151 DP - 2026 Nov TI - Total energy expenditure and its components in healthy young adults from Southwest China using doubly labeled water, indirect calorimetry, accelerometry, and energy intake. PG - 113350 LID - S0899-9007(26)00258-3 [pii] LID - 10.1016/j.nut.2026.113350 [doi] AB - BACKGROUND: Energy requirement (ER) in young adults is commonly estimated from predicted resting metabolic rate (RMR) and assumed physical activity level (PAL). These assumptions may not fully reflect free-living total energy expenditure (TEE) in healthy young adults from Southwest China with low-activity daily routines. OBJECTIVE: This study compared doubly labeled water (DLW)-measured TEE with factorial TEE based on measured RMR and with equation-estimated TEE, interpreted as estimated ER, derived from Chinese and FAO/WHO/UNU RMR prediction equations. Measured and predicted RMR, TEE partitioning, and energy intake-TEE agreement were also examined. METHODS: Twenty healthy adults aged 18-30 years from Southwest China completed a 7-d free-living assessment. TEE was measured using DLW, and RMR was measured by indirect calorimetry. Physical activity was assessed using triaxial accelerometry with activity records. Dietary intake was measured using the duplicate-portion method and laboratory analysis. PAL was calculated as TEE/RMR, and thermic effect of food (TEF) was estimated by difference. Agreement was further evaluated using Bland-Altman analysis. RESULTS: DLW-measured TEE was 2039.63 +/- 304.43 kcal/d and did not differ significantly from factorial TEE or equation-estimated TEE derived using the Chinese and FAO/WHO/UNU equations. However, Chinese equation-predicted RMR was significantly lower than measured RMR (1584.29 +/- 232.97 kcal/d, p < 0.05), whereas FAO/WHO/UNU-predicted RMR was comparable with measured RMR. Measured PAL was low (1.29 +/- 0.12), and RMR, physical activity energy expenditure (PAEE), and TEF accounted for 78.0%, 12.9%, and 9.1% of TEE, respectively. Energy intake was broadly comparable with DLW-measured TEE at the group level, although Bland-Altman analysis indicated individual-level variability. CONCLUSIONS: Equation-estimated TEE, interpreted as estimated ER, was broadly comparable with DLW-measured TEE at the group level. However, this apparent agreement depended on both RMR prediction and PAL assumptions. The findings support component-based evaluation of ER in young Chinese adults, with attention to RMR, PAL, PAEE, TEF, FQ, and energy balance. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Nie, Xiangzhen AU - Nie X AD - School of Food and Health, Guilin Tourism University, Guilin, Guangxi, China; Guangxi Engineering Research Center for Large-Scale Preparation, Nutrition and Hygiene of Guangxi Cuisine, Guilin, Guangxi, China. FAU - Liu, Ronghan AU - Liu R AD - School of Food and Health, Guilin Tourism University, Guilin, Guangxi, China; Guangxi Engineering Research Center for Large-Scale Preparation, Nutrition and Hygiene of Guangxi Cuisine, Guilin, Guangxi, China. FAU - Yan, Xiantao AU - Yan X AD - Guangdong Key Laboratory of Functional Substances and Health Products from Medicinal Edible Resources, Hanshan Normal University, Chaozhou, Guangdong, China. Electronic address: yanyang214@126.com. FAU - Tian, Ying AU - Tian Y AD - School of Basic Medical Sciences & School of Public Health, Yangzhou University, Yangzhou, Jiangsu, China. FAU - Al-Dalali, Sam AU - Al-Dalali S AD - School of Food and Health, Guilin Tourism University, Guilin, Guangxi, China; Guangxi Engineering Research Center for Large-Scale Preparation, Nutrition and Hygiene of Guangxi Cuisine, Guilin, Guangxi, China. FAU - Jiang, Mengchao AU - Jiang M AD - School of Food and Health, Guilin Tourism University, Guilin, Guangxi, China. FAU - Ni, Xinling AU - Ni X AD - School of Food and Health, Guilin Tourism University, Guilin, Guangxi, China. LA - eng PT - Journal Article DEP - 20260703 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Humans MH - *Energy Metabolism/physiology MH - Calorimetry, Indirect/methods MH - Adult MH - Young Adult MH - Female MH - *Energy Intake/physiology MH - China MH - Basal Metabolism MH - Adolescent MH - Male MH - Accelerometry/methods MH - Exercise MH - Nutritional Requirements OTO - NOTNLM OT - Calorimetry OT - Energy intake OT - Energy metabolism OT - Resting metabolic rate OT - Validation studies OT - Young adults OT - indirect COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/08/01 00:36 MHDA- 2026/08/25 23:33 CRDT- 2026/07/31 18:07 PHST- 2026/05/06 00:00 [received] PHST- 2026/06/12 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/08/25 23:33 [medline] PHST- 2026/08/01 00:36 [pubmed] PHST- 2026/07/31 18:07 [entrez] AID - S0899-9007(26)00258-3 [pii] AID - 10.1016/j.nut.2026.113350 [doi] PST - ppublish SO - Nutrition. 2026 Nov;151:113350. doi: 10.1016/j.nut.2026.113350. Epub 2026 Jul 3. PMID- 42537500 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260826 IS - 1879-0739 (Electronic) IS - 0271-5317 (Linking) VI - 153 DP - 2026 Sep TI - Moderate MIND diet adherence and positive correlation between weekly egg intake and skin carotenoid scores in college students. PG - 78-85 LID - S0271-5317(26)00086-2 [pii] LID - 10.1016/j.nutres.2026.07.003 [doi] AB - Adherence to the Mediterranean-DASH diet intervention for neurodegenerative delay (MIND) diet, which emphasizes fruit and vegetables and thereby carotenoid intake, is associated with better cognitive health in older adults. However, as neurodegeneration is thought to progress over decades, adopting such a dietary pattern in young adulthood may help prevent its initiation and progression. The aim of this study was to determine whether scores on the MIND diet screener predict skin carotenoid scores in college students, as a measure of construct validity. Participants completed a modified 14-item MIND diet screener and an item on weekly egg intake. Skin carotenoids were assessed using pressure-mediated reflective spectroscopy by Veggie Meter, and the data were analyzed using Pearson correlations. Participants (n = 293; 62.5% female; 20.0 +/- 2.0 years) scored 8.3 +/- 2.1 on the screener, indicating suboptimal adherence to the MIND dietary pattern, and skin carotenoid scores averaged 305 +/- 90. MIND diet screener score predicted skin carotenoid score (r = 0.327; CI 0.220-0.425; P < .001), strengthened by adding the egg intake item (r = 0.353; CI 0.249-0.450; P < .001), and was highest in those consuming >/=7 eggs/wk (r = 0.50). Two dietary patterns emerged from clustering analysis, differentiated by intakes of leafy greens, other vegetables, berries, beans, and nuts. In conclusion, the MIND diet screener score predicts skin carotenoid content in young adults, supporting the tool's validity; however, frequent egg intake strongly moderated the relationship. Egg intake should be considered when interpreting skin carotenoid scores and included in future iterations of the MIND diet screener. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Hill, Chloe AU - Hill C AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Foster, Victoria R AU - Foster VR AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Patel, Arya B AU - Patel AB AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Ribay, Gabriel D AU - Ribay GD AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Sadlo, Margaret K AU - Sadlo MK AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Senthilkumar, Neha AU - Senthilkumar N AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Moreno, Melissa L AU - Moreno ML AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. FAU - Colee, James AU - Colee J AD - Institute of Food and Agricultural Sciences (IFAS) Statistics Department, University of Florida, Gainesville, FL, USA. FAU - Dahl, Wendy J AU - Dahl WJ AD - Department of Food Science and Human Nutrition, University of Florida, Gainesville, FL, USA. Electronic address: wdahl@ufl.edu. LA - eng PT - Journal Article DEP - 20260708 PL - United States TA - Nutr Res JT - Nutrition research (New York, N.Y.) JID - 8303331 RN - 36-88-4 (Carotenoids) SB - IM MH - Humans MH - Female MH - *Carotenoids/analysis MH - Male MH - *Skin/chemistry MH - Students MH - *Eggs MH - Young Adult MH - *Diet, Mediterranean MH - Vegetables MH - Fruit MH - Universities MH - Adolescent MH - *Feeding Behavior MH - Adult MH - Diet MH - *Patient Compliance OTO - NOTNLM OT - Carotenoids OT - Diet OT - Diet surveys OT - Egg yolk OT - Mediterranean-DASH diet intervention for neurodegenerative delay OT - Plant-based OT - Reflection spectroscopy COIS- Author declarations All authors declare that the research was conducted without commercial or financial relationships and that there is no conflict of interest. EDAT- 2026/08/01 00:36 MHDA- 2026/08/26 23:35 CRDT- 2026/07/31 18:06 PHST- 2026/02/16 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/08/26 23:35 [medline] PHST- 2026/08/01 00:36 [pubmed] PHST- 2026/07/31 18:06 [entrez] AID - S0271-5317(26)00086-2 [pii] AID - 10.1016/j.nutres.2026.07.003 [doi] PST - ppublish SO - Nutr Res. 2026 Sep;153:78-85. doi: 10.1016/j.nutres.2026.07.003. Epub 2026 Jul 8. PMID- 42536949 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260731 IS - 0043-5147 (Print) IS - 0043-5147 (Linking) VI - 79 IP - 6 DP - 2026 TI - Diagnostic value of lateral cephalometric parameters in determining vertical and horizontal maxillofacial growth patterns. PG - 1312-1322 LID - 10.36740/WLek/222584 [doi] AB - OBJECTIVE: Aim: To assess the diagnostic value of qualitative and quantitative lateral cephalometric parameters in determining vertical, horizontal, and neutral maxillofacial growth patterns in patients with orthodontic pathology. PATIENTS AND METHODS: Materials and Methods: The study included 292 lateral cephalograms of patients aged 5 to 50 years who sought orthodontic consultation. Eleven quantitative cephalometric parameters were analysed in the full sample. In a randomised subgroup of 160 cephalograms, seven additional qualitative parameters were assessed. Growth pattern determination was performed using an integrated approach based on the absolute majority of diagnostic signs. In addition, 134 cephalograms were independently evaluated by 34 orthodontic trainees using qualitative characteristics only. The diagnostic performance of each parameter was assessed using balanced accuracy, sensitivity, specificity, and positive predictive value. RESULTS: Results: Among 292 patients, 121 had a neutral growth pattern, 103 a vertical pattern, and 68 a horizontal pattern. Evaluation based only on qualitative signs resulted in correct classification in 60.45% of cases on average. Among quantitative parameters, angleN-Go-Me demonstrated the highest diagnostic performance, with a positive predictive value of 82.9%, followed by angleAr-Go-Me and anglePn-MP. Among qualitative parameters, the mandibular angle, condylar process height, and contour of the lower mandibular border showed the highest diagnostic value. CONCLUSION: Conclusions: Quantitative cephalometric parameters, particularly angleN-Go-Me, are more diagnostically reliable than isolated qualitative assessment for determining maxillofacial growth patterns. A combined approach may improve diagnostic accuracy in orthodontic treatment planning. FAU - Drohomyretska, Myroslava S AU - Drohomyretska MS AD - SHUPYK NATIONAL HEALTHCARE UNIVERSITY OF UKRAINE, KYIV, UKRAINE. FAU - Tkachenko, Yulia V AU - Tkachenko YV AD - SHUPYK NATIONAL HEALTHCARE UNIVERSITY OF UKRAINE, KYIV, UKRAINE. FAU - Garmash, Olga V AU - Garmash OV AD - KHARKIV NATIONAL MEDICAL UNIVERSITY, KHARKIV, UKRAINE. LA - eng PT - Journal Article PL - Poland TA - Wiad Lek JT - Wiadomosci lekarskie (Warsaw, Poland : 1960) JID - 9705467 SB - IM MH - Humans MH - *Cephalometry/methods MH - Female MH - Child MH - *Maxillofacial Development/physiology MH - Male MH - Adolescent MH - Adult MH - Middle Aged MH - Child, Preschool MH - Young Adult MH - Sensitivity and Specificity OTO - NOTNLM OT - cephalometry OT - craniofacial growth OT - orthodontics OT - vertical dimension EDAT- 2026/07/31 18:35 MHDA- 2026/07/31 18:36 CRDT- 2026/07/31 15:42 PHST- 2026/07/31 18:36 [medline] PHST- 2026/07/31 18:35 [pubmed] PHST- 2026/07/31 15:42 [entrez] AID - 10.36740/WLek/222584 [doi] PST - ppublish SO - Wiad Lek. 2026;79(6):1312-1322. doi: 10.36740/WLek/222584. PMID- 42536608 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Applications of the Behavior Change Wheel in promoting physical activity among children and adolescents: A scoping review. PG - e0354697 LID - 10.1371/journal.pone.0354697 [doi] LID - e0354697 AB - BACKGROUND: Physical inactivity among children and adolescents remains a major global public health concern, yet the ways in which behavioral theory is applied to inform physical activity (PA) interventions are often insufficiently described. The Behavior Change Wheel (BCW) model provides a systematic framework for linking behavioral determinants to intervention content, but its application in PA promotion for this population has not been comprehensively mapped. METHODS: This scoping review was conducted in accordance with the Joanna Briggs Institute methodology and reported following the PRISMA-ScR guideline. Seven electronic databases were searched for studies published since 2011 that explicitly applied the BCW to promote PA among children and adolescents. Data were charted on study characteristics, targeted components of the Capability, Opportunity, and Motivation-Behavior (COM-B) model, BCW intervention functions, behavior change techniques, and implementation outcomes. RESULTS: Fifteen studies met the inclusion criteria. Most applications focused on intervention development, co-design, or feasibility rather than effectiveness evaluation. Psychological capability and reflective motivation were the most frequently targeted COM-B components, and education, training, and enablement were the dominant intervention functions. Commonly used behavior change techniques included goal setting, action planning, self-monitoring, feedback, and social support. Functions involving coercion or restriction were rarely used. Reporting of implementation outcomes was inconsistent, with limited attention to reach, penetration, and sustainability. CONCLUSIONS: In studies using the BCW framework, PA interventions for children and adolescents predominantly emphasize individual-level self-regulation strategies, with less focus on opportunity-level change and implementation sustainability. Greater transparency in theoretical mapping and stronger integration of implementation considerations are needed to enhance the translation of theory-based interventions into practice. CI - Copyright: (c) 2026 Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Huang, Zheng AU - Huang Z AD - Department of Physical Education, Changzhou Institute of Technology, Changzhou, China. FAU - Fang, Shuguang AU - Fang S AD - Department of Physical Education, Changzhou Institute of Technology, Changzhou, China. FAU - Peng, Sanying AU - Peng S AUID- ORCID: 0000-0001-6007-7403 AD - Department of Physical Education, Hohai University, Nanjing, China. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260731 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Child MH - Adolescent MH - *Exercise/psychology MH - *Health Promotion/methods MH - Motivation MH - *Health Behavior PMC - PMC13426998 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/31 18:35 MHDA- 2026/07/31 18:36 PMCR- 2026/07/31 CRDT- 2026/07/31 13:24 PHST- 2026/01/23 00:00 [received] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/07/31 18:36 [medline] PHST- 2026/07/31 18:35 [pubmed] PHST- 2026/07/31 13:24 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - PONE-D-26-02954 [pii] AID - 10.1371/journal.pone.0354697 [doi] PST - epublish SO - PLoS One. 2026 Jul 31;21(7):e0354697. doi: 10.1371/journal.pone.0354697. eCollection 2026. PMID- 42534148 OWN - NLM STAT- Publisher LR - 20260923 IS - 1091-367X (Print) IS - 1532-7841 (Electronic) IS - 1091-367X (Linking) DP - 2026 Jul 16 TI - Measurement Reactivity to Hip-Worn Accelerometry Among Adolescent Females: A Concurrent Wear Approach. LID - 10.1080/1091367x.2026.2704743 [doi] AB - Device-based measurement of physical activity (PA) is crucial for valid research, but reactivity to these devices can undermine validity. Inconsistent findings in prior reactivity research warrant unique approaches among diverse populations, including those habituated to wearing another device. We aimed to estimate reactivity to ActiGraph GT3X+ via concurrent Fitbit Inspire HR wear among Latina adolescents using a person-day matched cross-sectional design. Fitbit data estimated steps, moderate-vigorous PA, light PA, and sedentary time for all days in the 2 weeks preceding and following matched ActiGraph wear days. Linear models estimated the association of ActiGraph wear day with activity after adjustment for covariates. There were 2987 total days across 107 participants, ~35% classified as ActiGraph wear days. Steps statistically significantly differed (p = .0499) with ActiGraph wear days corresponding to 248 greater average steps. Measurement reactivity to ActiGraph may impact steps among adolescent females. Future research could benefit from concurrent wear strategies if feasible. FAU - Carson, Jacob AU - Carson J AD - Herbert Wertheim School of Public Health and Human Longevity, University of California San Diego, La Jolla, California, USA. FAU - Castro, Esmeralda AU - Castro E AD - Family Medicine and Public Health, University of California San Diego, La Jolla, California, USA. FAU - Higgins, Michael AU - Higgins M AD - EPARC, University of California San Diego, La Jolla, California, USA. FAU - Godino, Job AU - Godino J AD - Laura Rodriguez Research Institute, Family Health Centers of San Diego, San Diego, California, USA. FAU - Larsen, Britta AU - Larsen B AD - Herbert Wertheim School of Public Health and Human Longevity, University of California San Diego, La Jolla, California, USA. LA - eng GR - R01 NR017876/NR/NINR NIH HHS/United States GR - T32 HL079891/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260716 PL - United States TA - Meas Phys Educ Exerc Sci JT - Measurement in physical education and exercise science JID - 100893864 PMC - PMC13419367 MID - NIHMS2196539 OTO - NOTNLM OT - Physical activity OT - accelerometry OT - consumer wearables OT - free-living activity OT - pedometry COIS- Disclosure statement No potential conflict of interest was reported by the author(s). EDAT- 2026/07/31 06:36 MHDA- 2026/07/31 06:36 PMCR- 2026/07/31 CRDT- 2026/07/31 05:15 PHST- 2026/07/31 06:36 [medline] PHST- 2026/07/31 06:36 [pubmed] PHST- 2026/07/31 05:15 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - 10.1080/1091367x.2026.2704743 [doi] PST - aheadofprint SO - Meas Phys Educ Exerc Sci. 2026 Jul 16:10.1080/1091367x.2026.2704743. doi: 10.1080/1091367x.2026.2704743. PMID- 42533614 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260903 IS - 1545-5017 (Electronic) IS - 1545-5009 (Linking) VI - 73 IP - 10 DP - 2026 Oct TI - Navigating the Planning and Initiation of a First Prospective Clinical Trial Through a Regional Pediatric Oncology Consortium Within the Middle East, Africa, and Asia-A Roadmap. PG - e70556 LID - 10.1002/1545-5017.70556 [doi] AB - BACKGROUND: Prospective pediatric oncology clinical trials remain scarce across low- and middle-income countries (LMICs). We developed the first multicountry prospective clinical trial within the Pediatric Oncology East and Mediterranean (POEM) group. Localized osteosarcoma was selected due to heterogeneous real-world management, including alternative regimens in settings where methotrexate administration is not feasible. This descriptive report details the feasibility of a regionally coordinated, resource-adapted clinical trial across diverse LMIC settings. METHODS: We describe the planning, capacity assessment, training, governance, and activation of POEM-OS, a pragmatic two-arm prospective cohort study evaluating MAP- and OS99-based therapy for localized osteosarcoma. Preparation included a structured capacity-mapping exercise across regional centers to assess clinical resources, research, and regulatory structures. The approach also encompassed designing a training program and communication through a structured study coordination team. RESULTS: A total of 27 centers from 10 countries expressed intent to participate. A 12-week virtual training curriculum was implemented for principal investigator and clinical research coordinator dyads, followed by an in-person regional workshop. Eventually, 21 centers (8 countries) proceeded to study activation. Major barriers included heterogeneity in chemotherapy administration, high staff turnover, and variability in timelines to study-agreement execution. Adaptive solutions included permanently accessible online training modules, simplified chemotherapy dosing, and harmonized toxicity grading. Centralized REDCap platforms enabled regional data sharing. By February 2026, the study had opened at 16 centers, with 21 patients enrolled. CONCLUSION: POEM-OS demonstrates that a regionally directed, resource-adapted clinical trial platform is feasible across diverse LMIC settings and establishes a foundation for sustainable regional clinical research infrastructure. CI - (c) 2026 Wiley Periodicals LLC. FAU - Papyan, Ruzanna AU - Papyan R AUID- ORCID: 0000-0003-1949-6280 AD - Department of Hematology and Pediatric Oncology, Yerevan State Medical University, Yerevan, Armenia. AD - Yeolyan Hematology and Oncology Center, Yerevan, Armenia. AD - Immune Oncology Research Institute, Yerevan, Armenia. FAU - Ghamloush, Farah AU - Ghamloush F AD - Department of Anatomy, Cell Biology and Physiological Sciences and POEM Central Office, American University of Beirut, Beirut, Lebanon. FAU - Sidhom, Iman AU - Sidhom I AD - Department of Pediatric Oncology, National Cancer Institute, Cairo University and Children's Cancer Hospital Egypt, Cairo, Egypt. FAU - Belgaumi, Asim AU - Belgaumi A AUID- ORCID: 0000-0002-0135-7509 AD - Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Nasr, Rihab AU - Nasr R AD - Department of Anatomy, Cell Biology and Physiological Sciences and POEM Central Office, American University of Beirut, Beirut, Lebanon. FAU - Sultan, Iyad AU - Sultan I AD - King Hussein Cancer Center, Amman, Jordan. FAU - Tamamyan, Gevorg AU - Tamamyan G AD - Department of Hematology and Pediatric Oncology, Yerevan State Medical University, Yerevan, Armenia. AD - Immune Oncology Research Institute, Yerevan, Armenia. FAU - Radhakrishnan, Venkatraman AU - Radhakrishnan V AUID- ORCID: 0000-0002-7557-5816 AD - Department of Medical Oncology, Cancer Institute (W.I.A), Chennai, India. FAU - Rodriguez-Galindo, Carlos AU - Rodriguez-Galindo C AUID- ORCID: 0000-0002-2360-8946 AD - Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. AD - Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Jeha, Sima AU - Jeha S AUID- ORCID: 0000-0003-2835-5869 AD - Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. AD - Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Santana, Victor M AU - Santana VM AUID- ORCID: 0000-0003-0320-5776 AD - Department of Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. AD - Department of Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA. FAU - Saab, Raya AU - Saab R AUID- ORCID: 0000-0001-5776-2303 AD - Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA. LA - eng GR - Programme for Advancing the Research Capacity/ GR - International Society of Paediatric Oncology/ GR - American Lebanese Syrian Associated Charities/ PT - Journal Article PT - Multicenter Study DEP - 20260731 PL - United States TA - Pediatr Blood Cancer JT - Pediatric blood & cancer JID - 101186624 SB - IM MH - Humans MH - Prospective Studies MH - Middle East MH - Child MH - *Clinical Trials as Topic MH - *Osteosarcoma/drug therapy MH - Asia MH - Africa MH - Resource-Limited Settings MH - *Bone Neoplasms/drug therapy MH - Developing Countries MH - Female MH - *Medical Oncology OTO - NOTNLM OT - clinical trial OT - global oncology OT - low- and middle-income countries (LMICs) OT - osteosarcoma OT - research capacity EDAT- 2026/07/31 06:36 MHDA- 2026/08/25 17:35 CRDT- 2026/07/31 03:13 PHST- 2026/06/14 00:00 [revised] PHST- 2026/04/15 00:00 [received] PHST- 2026/06/27 00:00 [accepted] PHST- 2026/08/25 17:35 [medline] PHST- 2026/07/31 06:36 [pubmed] PHST- 2026/07/31 03:13 [entrez] AID - 10.1002/1545-5017.70556 [doi] PST - ppublish SO - Pediatr Blood Cancer. 2026 Oct;73(10):e70556. doi: 10.1002/1545-5017.70556. Epub 2026 Jul 31. PMID- 42533515 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260731 IS - 1899-5276 (Print) IS - 1899-5276 (Linking) VI - 35 IP - 7 DP - 2026 Jul TI - Family and dietary risk factors associated with childhood sleep disorders: Evidence from a cross-sectional study in China. PG - 1235-1245 LID - 10.17219/acem/212573 [doi] AB - BACKGROUND: Childhood sleep disorders are common and are associated with familyand diet-related factors, such as parental snoring and unhealthy eating habits. However, culturally relevant studies remain limited, and existing research often overlooks weak correlations in large populations. OBJECTIVES: This study aimed to identify familyand diet-related risk factors for childhood sleep disorders in a Chinese population and to provide insights for prevention. MATERIAL AND METHODS: A cross-sectional study was conducted in Jinan, China, between January 2022 and December 2023, enrolling 845 children aged 1-7 years through convenience sampling. Sleep disorders were defined based on parent-reported symptoms (mouth breathing, habitual snoring, apnea, or gasping) using a validated questionnaire. Demographic, family, and dietary factors were collected. Associations were analyzed using multivariable logistic regression with stepwise selection based on the Akaike information criterion (AIC), adjusted for age, with subgroup analyses according to age (1-3, 4-5, and 6-7 years). Statistical significance was set at p < 0.05. RESULTS: Among the 845 children (mean age: 5.2 years), 192 (22.7%) had sleep disorders. Multivariable analysis showed that parental snoring (father: odds ratio (OR) = 2.20, 95% confidence interval (95% CI): 1.44-3.41; mother: OR = 1.76, 95% CI: 1.15-2.66), maternal education at the associate degree level (OR = 2.58, 95% CI: 1.27-5.66) or bachelor's degree level (OR = 2.44, 95% CI: 1.21-5.29), and children's preferences for fried foods (OR = 6.49, 95% CI: 2.51-17.40), meat (OR = 2.19, 95% CI: 1.43-3.35), and sweets (OR = 2.15, 95% CI: 1.31-3.51) were significant risk factors. Moderate sweet consumption (1-2 times/week: OR = 0.53, 95% CI: 0.29-0.95; 3-5 times/week: OR = 0.51, 95% CI: 0.27-0.94) was associated with a protective effect compared with daily consumption. CONCLUSIONS: Childhood sleep disorders were significantly associated with parental snoring, higher maternal educational attainment, and children's preferences for fried foods, meat, and sweets, whereas moderate sweet consumption appeared to have a protective effect. FAU - Zhang, Lifeng AU - Zhang L AD - The First College for Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China. AD - Department of Otolaryngology, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China. FAU - Chen, Xiangjing AU - Chen X AD - Department of Otolaryngology, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China. FAU - Zhang, Xin AU - Zhang X AD - Department of Otolaryngology, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China. FAU - Yan, Ya AU - Yan Y AD - The First College for Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China. FAU - Wang, Renzhong AU - Wang R AD - Department of Otolaryngology, Shandong University of Traditional Chinese Medicine Affiliated Hospital, Jinan, China. LA - eng PT - Journal Article PL - Poland TA - Adv Clin Exp Med JT - Advances in clinical and experimental medicine : official organ Wroclaw Medical University JID - 101138582 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Risk Factors MH - Female MH - *Sleep Wake Disorders/epidemiology/etiology MH - China/epidemiology MH - Child, Preschool MH - Male MH - Child MH - *Diet/adverse effects MH - Infant MH - Feeding Behavior MH - Snoring MH - Surveys and Questionnaires OTO - NOTNLM OT - childhood sleep disorders OT - dietary habits OT - maternal education OT - parental snoring OT - risk factors EDAT- 2026/07/31 06:37 MHDA- 2026/07/31 12:39 CRDT- 2026/07/31 02:02 PHST- 2025/06/18 00:00 [received] PHST- 2025/10/14 00:00 [accepted] PHST- 2026/07/31 12:39 [medline] PHST- 2026/07/31 06:37 [pubmed] PHST- 2026/07/31 02:02 [entrez] AID - 10.17219/acem/212573 [doi] PST - ppublish SO - Adv Clin Exp Med. 2026 Jul;35(7):1235-1245. doi: 10.17219/acem/212573. PMID- 42532561 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260918 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 7 DP - 2026 Jul 30 TI - Vietnam Cerebral Palsy Register: protocol for co-design of a national register with people with lived experience of cerebral palsy. PG - e116376 LID - 10.1136/bmjopen-2026-116376 [doi] LID - e116376 AB - INTRODUCTION: Cerebral palsy (CP) is the most common physical disability in childhood. Although an estimated 60 000 children live with CP in Vietnam, there is no national register to systematically collect data on the prevalence, risk factors or clinical profile of CP or service access. This paper outlines the protocol for establishing the Vietnam Cerebral Palsy Register (VCPR), a national register which will be co-designed by researchers and clinicians in collaboration with the Cerebral Palsy Family Association of Vietnam (CPFAV). The VCPR aims to inform service planning, policy and research through comprehensive, community-informed data collection. METHODS AND ANALYSIS: The VCPR will be developed by a consumer-clinician-researcher partnership. Initially, the VCPR will harmonise and pool data from two sources: (1) a hospital-based cohort of 765 children with CP identified at the National Children's Hospital in Hanoi (NCH) in 2017, and (2) members of the CPFAV, comprising over 4300 children with CP aged <18 years from 63 CPFAV hubs across Vietnam. Subsequently, standardised data for inclusion in the VCPR will prospectively be collected on children newly diagnosed with CP at NCH and other healthcare settings and on children newly referred to CPFAV.Data will be collected using an adapted version of the Australian CP register questionnaire through a combination of structured caregiver interviews, clinical assessments using validated tools and medical record review. Key demographic variables and information on CP type, motor severity-using the Gross Motor Function Classification System or Manual Ability Classification System, associated impairments (eg, vision, hearing, intellectual disabilities), condition at birth, congenital or other infections, vaccination, educational and nutritional status of the child, access to rehabilitation and family-related factors such as monthly household income, parental education and occupation and maternal health during pregnancy will be collected. The VCPR will contribute data to the Global Low- and Middle-Income Country Cerebral Palsy Register. ETHICS AND DISSEMINATION: Ethics approval has been obtained from Vietnamese and Australian institutions, whose role is to provide ethical oversight and research governance for the PhD project supporting the VCPR. Written informed consent will be obtained from primary caregivers for data collection, secure storage, access to relevant health records, verification with health professionals and future research contact, with no identifiable data disclosed.Involvement of people with lived experience of CP is central to the VCPR and leaders and members of the CPFAV will contribute to co-design, governance, participant engagement and dissemination. Findings will be shared regularly with families, clinicians, policymakers and researchers through CPFAV communications, peer-reviewed publications, national and international conferences and the VCPR website to inform equitable service planning, policy and future research. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Khuc, Thi Hong Hanh AU - Khuc THH AUID- ORCID: 0000-0002-9421-5517 AD - School of Health, Medical and Applied Sciences, Central Queensland University, Rockhampton, Queensland, Australia honghanhkhuc@gmail.com. AD - Faculty of Medical Technology, Phenikaa School of Medicine and Pharmacy, Phenikaa University, Hanoi, Viet Nam. FAU - Cao, Minh Chau AU - Cao MC AD - Faculty of Medical Technology, Phenikaa School of Medicine and Pharmacy, Phenikaa University, Hanoi, Viet Nam. FAU - Karim, Tasneem AU - Karim T AD - Cerebral Palsy Alliance Research Institute, Specialty of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. AD - Specialty of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. FAU - Dinh, Thi Lan Anh AU - Dinh TLA AD - Cerebral Palsy Family Association Vietnam, Hanoi, Viet Nam. FAU - Nguyen, Thi Huong Giang AU - Nguyen THG AD - Department of Rehabilitation, National Children's Hospital, Hanoi, Viet Nam. FAU - Nguyen, Thi Van Anh AU - Nguyen TVA AUID- ORCID: 0000-0002-3673-7288 AD - Department of Rehabilitation, National Children's Hospital, Hanoi, Viet Nam. FAU - Pham, Minh Chau AU - Pham MC AD - Faculty of Medical Technology, Phenikaa School of Medicine and Pharmacy, Phenikaa University, Hanoi, Viet Nam. FAU - Nguyen, Van Bang AU - Nguyen VB AD - Medical Faculty, Hoa Binh University, Hanoi, Viet Nam. FAU - Rawal, Lal AU - Rawal L AUID- ORCID: 0000-0003-1106-0108 AD - School of Health Medical and Applied Sciences, Central Queensland University, Sydney, New South Wales, Australia. AD - S.P.O.R.T. Research Cluster, Central Queensland University, Rockhampton, Queensland, Australia. FAU - Mcintyre, Sarah AU - Mcintyre S AD - Specialty of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. FAU - Khandaker, Gulam AU - Khandaker G AUID- ORCID: 0000-0002-0661-4113 AD - National Centre for Immunisation Research and Surveillance, Westmead, New South Wales, Australia. AD - Central Queensland Public Health Unit, Central Queensland Hospital and Health Service, Rockhampton, Queensland, Australia. FAU - Elliott, Elizabeth Jane AU - Elliott EJ AUID- ORCID: 0000-0002-6501-5487 AD - Specialty of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. AD - Kid's Research, The Sydney Children's Hospitals Network, Sydney, New South Wales, Australia. CN - Cerebral Palsy Family Association Vietnam LA - eng PT - Journal Article DEP - 20260730 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Cerebral Palsy/epidemiology MH - *Registries MH - Vietnam/epidemiology MH - Child MH - Adolescent MH - Child, Preschool MH - Female MH - Research Design MH - Male MH - Infant PMC - PMC13423169 OTO - NOTNLM OT - Community child health OT - Developmental neurology & neurodisability OT - Protocols & guidelines OT - REGISTRIES COIS- Competing interests: None declared. EDAT- 2026/07/31 00:38 MHDA- 2026/07/31 00:39 PMCR- 2026/07/30 CRDT- 2026/07/30 20:43 PHST- 2026/07/31 00:39 [medline] PHST- 2026/07/31 00:38 [pubmed] PHST- 2026/07/30 20:43 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - bmjopen-2026-116376 [pii] AID - 10.1136/bmjopen-2026-116376 [doi] PST - epublish SO - BMJ Open. 2026 Jul 30;16(7):e116376. doi: 10.1136/bmjopen-2026-116376. PMID- 42531751 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260907 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 90 DP - 2026 Sep-Oct TI - Ninety years apart: Comparing pediatric growth charts used in Australia in the 1930s against modern standards. PG - 782-787 LID - S0882-5963(26)00362-3 [pii] LID - 10.1016/j.pedn.2026.07.060 [doi] AB - BACKGROUND: Growth charts have evolved since their introduction in the 18th century, with various organizations refining them to reflect the growth patterns of the populations they serve. In this context, this study compared growth tables published in a 1930s Australian child-health text by Dr. Isie Ross with contemporary growth charts used in pediatric practice. MATERIALS AND METHODS: Values from Ross's historical growth tables were extracted and plotted against current standardized growth references for children (WHO and CDC). Both Wilcoxon signed-rank test and Bland-Altman analysis were used to assess agreement and differences between the two data sources. RESULTS: Growth patterns from the 1930s showed some similarity to those in modern charts, with relatively small variation across most age groups, suggesting broad stability in early childhood growth over time. Clinically, however, the findings indicate limited applicability of historical references for assessing overweight, with greater secular change and variability observed at the upper growth percentiles. Overall, this highlights population-level stability in growth trajectories but poor clinical interchangeability between historical and contemporary references. CONCLUSIONS: Historical growth data may be more consistent with contemporary standards than commonly assumed. Examining such texts can enhance awareness of early contributions to pediatric growth assessment and highlighting the continued relevance of foundational work in child health despite its limited clinical interchangeability with modern references. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Al-Motlaq, Mohammad A AU - Al-Motlaq MA AD - Department of Maternal Child and Family Health, Faculty of Nursing, The Hashemite University, Zarqa, Jordan. Electronic address: Mohammada_m@hu.edu.jo. FAU - Shields, Linda AU - Shields L AD - Honorary Professor, Faculty of Medicine, The University of Queensland, Queensland, Australia. Electronic address: l.e.shields@uq.edu.au. LA - eng PT - Comparative Study PT - Historical Article PT - Journal Article DEP - 20260730 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM MH - Humans MH - *Growth Charts MH - Australia MH - Child MH - History, 20th Century MH - Child, Preschool MH - *Child Development/physiology MH - Infant MH - Female MH - Male MH - Reference Values MH - *Pediatrics/history MH - Infant, Newborn OTO - NOTNLM OT - Australia OT - Charts OT - Child health OT - Growth tables OT - History COIS- Declaration of competing interest MA is an associate editor at the JPN. EDAT- 2026/07/31 00:38 MHDA- 2026/09/07 23:34 CRDT- 2026/07/30 18:04 PHST- 2026/01/07 00:00 [received] PHST- 2026/07/25 00:00 [revised] PHST- 2026/07/25 00:00 [accepted] PHST- 2026/09/07 23:34 [medline] PHST- 2026/07/31 00:38 [pubmed] PHST- 2026/07/30 18:04 [entrez] AID - S0882-5963(26)00362-3 [pii] AID - 10.1016/j.pedn.2026.07.060 [doi] PST - ppublish SO - J Pediatr Nurs. 2026 Sep-Oct;90:782-787. doi: 10.1016/j.pedn.2026.07.060. Epub 2026 Jul 30. PMID- 42531291 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260828 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Resilience factors, pain, and physical activity in adolescent chronic musculoskeletal pain: Design and protocol of a pilot phase 2 single-group, non-randomized clinical trial. PG - e0353010 LID - 10.1371/journal.pone.0353010 [doi] LID - e0353010 AB - INTRODUCTION: Chronic musculoskeletal pain (CMSKP) in adolescence is associated with physical, psychological, social, and academic impairment and increased risk for chronic pain in adulthood. Although physical activity interventions are an evidence-based approach for managing pediatric chronic pain, many adolescents with CMSKP avoid physical activity due to fear of increased pain, low confidence in physical functioning, and other pain-avoidance behaviors. Resilience-focused interventions targeting self-efficacy, motivation, and mental flexibility may improve engagement in valued activities despite pain. This study describes the design and protocol of the Pain REsilience Promotion for Youth (PREP-Y) intervention, a resilience-focused physical activity intervention for adolescents with CMSKP. METHODS AND ANALYSIS: This single-site, pilot phase 2, single-group, non-randomized clinical trial will enroll 40 adolescents aged 12-17 years with CMSKP from Nationwide Children's Hospital in Columbus, Ohio, USA. Participants complete questionnaires, objective physical functioning assessments, and physical activity monitoring using activPAL devices as baseline measures. Participants then complete 4 virtual resilience-focused intervention sessions targeting pain resilience, self-efficacy, motivation, and adaptive coping related to physical activity. Garmin watches are used to track activity during the intervention period. Follow-up assessments occur post-intervention and at 3 months post-intervention. Primary outcomes include feasibility and acceptability, assessed through recruitment, retention, attendance, intervention fidelity, and completion of study measures. Exploratory outcomes include physical activity, sedentary behavior, pain-related functioning, pain catastrophizing, kinesiophobia, self-efficacy, and resilience-related constructs. ETHICS AND DISSEMINATION: The study was approved by the Nationwide Children's Hospital Institutional Review Board. Findings will inform a future randomized clinical trial. This manuscript reflects protocol version 5.0 dated 23 March 2026. TRIAL REGISTRATION: ClinicalTrials.gov NCT06923891. CI - Copyright: (c) 2026 Logan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Logan, Faith AU - Logan F AUID- ORCID: 0009-0004-9662-114X AD - Behavioral Trials Office, Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America. FAU - Marsh, Madeline AU - Marsh M AUID- ORCID: 0009-0002-4142-0119 AD - Behavioral Trials Office, Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America. FAU - Hively, Adam AU - Hively A AUID- ORCID: 0009-0003-0501-2887 AD - Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America. FAU - Warner, Jacqueline AU - Warner J AD - Psychiatry and Behavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America. FAU - Davis, Ann AU - Davis A AD - Department of Pediatrics, University of Kansas Medical Center, Kansas City, Missouri, United States of America. AD - Center for Children's Healthy Lifestyles & Nutrition, Kansas City, Missouri, United States of America. FAU - Jackson, Jamie L AU - Jackson JL AD - Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America. AD - Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, United States of America. FAU - Black, William AU - Black W AD - Center for Biobehavioral Health, The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, Ohio, United States of America. LA - eng SI - ClinicalTrials.gov/NCT06923891 GR - K23 AR078337/AR/NIAMS NIH HHS/United States PT - Clinical Trial Protocol PT - Journal Article DEP - 20260730 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adolescent MH - *Musculoskeletal Pain/psychology/therapy/physiopathology MH - Pilot Projects MH - Child MH - *Exercise/psychology MH - Female MH - Male MH - *Chronic Pain/psychology/therapy/physiopathology MH - Self Efficacy MH - *Resilience, Psychological MH - Clinical Trials, Phase II as Topic PMC - PMC13422864 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/30 18:36 MHDA- 2026/07/30 18:37 PMCR- 2026/07/30 CRDT- 2026/07/30 13:44 PHST- 2026/06/30 00:00 [received] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/30 18:37 [medline] PHST- 2026/07/30 18:36 [pubmed] PHST- 2026/07/30 13:44 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - PONE-D-26-29534 [pii] AID - 10.1371/journal.pone.0353010 [doi] PST - epublish SO - PLoS One. 2026 Jul 30;21(7):e0353010. doi: 10.1371/journal.pone.0353010. eCollection 2026. PMID- 42531282 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Radiographic legal age estimation based on third molar development using Machine-learning algorithms. PG - e0354704 LID - 10.1371/journal.pone.0354704 [doi] LID - e0354704 AB - BACKGROUND: Age assessment plays an important role in forensic sciences to aid in criminal or civil matters. Third molars continue developing during the legal age of adulthood. Dental age estimation based on radiographic examination is an operator-dependent procedure. The aim was to test the performance of supervised machine learning (SML) to classify individuals according to the threshold of 18 years using the third molar index (I3m). METHODS: Panoramic radiographs (n = 597) of 52% males and 48% females between 13 and 26 years were used. Three Convolutional Neural Networks were compared to segment the third molar. Several machine learning algorithms were tested with a 10-fold cross-validation approach to identify the best age classification algorithm. The SML age estimation model was compared to the expert. RESULTS: Attention U-Net achieved the highest segmentation scores, and the k-nearest neighbors (KNN) showed the best scores of classification algorithms. The SML (KNN) scored sensitivity = 77.77%, specificity = 96%, and AUC = 0.87 in males. In females, sensitivity = 77.4%, specificity = 86.7%, and AUC = 0.82. The expert scores were: sensitivity = 70.4%, specificity = 100%, AUC = 0.85 for male, and for female: sensitivity = 54.8%, specificity = 93.3%, AUC = 0.74. CONCLUSION: SML classified males and females below and above the legal age with high accuracy compared to manual methods. The presented work suggests that AI, using pixel-level analysis, can detect subtle cues beyond human perception. This signals a possible departure from traditional age estimation indices. CI - Copyright: (c) 2026 Alsufyani et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Alsufyani, Noura AU - Alsufyani N AUID- ORCID: 0000-0002-7627-5073 AD - Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. FAU - Alowa, Sawsan AU - Alowa S AD - Riyadh, Saudi Arabia. FAU - Alrasheed, Hend AU - Alrasheed H AD - Department of Information Technology, College of Computer and Information Sciences, King Saud University, Riyadh, Saudi Arabia. FAU - Alqahtani, Sakher AU - Alqahtani S AD - Department of Pediatric Dentistry and Orthodontics, College of Dentistry, King Saud University, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260730 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - *Molar, Third/diagnostic imaging/growth & development MH - *Age Determination by Teeth/methods MH - Male MH - Adolescent MH - *Machine Learning MH - Young Adult MH - Algorithms MH - Adult MH - Radiography, Panoramic/methods MH - Classification Algorithms MH - Convolutional Neural Networks MH - Prediction Algorithms PMC - PMC13422845 COIS- NONE. EDAT- 2026/07/30 18:36 MHDA- 2026/07/30 18:37 PMCR- 2026/07/30 CRDT- 2026/07/30 13:44 PHST- 2025/12/05 00:00 [received] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/07/30 18:37 [medline] PHST- 2026/07/30 18:36 [pubmed] PHST- 2026/07/30 13:44 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - PONE-D-25-62206 [pii] AID - 10.1371/journal.pone.0354704 [doi] PST - epublish SO - PLoS One. 2026 Jul 30;21(7):e0354704. doi: 10.1371/journal.pone.0354704. eCollection 2026. PMID- 42531267 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260730 LR - 20260825 IS - 2767-3375 (Electronic) IS - 2767-3375 (Linking) VI - 6 IP - 7 DP - 2026 TI - Prevalence, patterns and associated behavioural risk factors of multimorbidity in rural India: Cross-sectional analysis from the Andhra Pradesh Children and Parents Study (APCAPS). PG - e0006694 LID - 10.1371/journal.pgph.0006694 [doi] LID - e0006694 AB - The prevalence of multimorbidity is projected to increase substantially in India. Previous studies have focused on urban populations and older adults, who do not represent the majority of those at risk. We aimed to estimate the prevalence and investigate patterns of multimorbidity in a rural population in India and examine their associations with four common behavioural risk factors (BRFs): daily drinking, tobacco consumption, physical inactivity, and poor sleep. This cross-sectional analysis used data of all adult participants (aged >/=18 years, mean age of 35.5 years) from the third follow-up of Andhra Pradesh Children and Parents Study (APCAPS), 2010-12. We used binary logistic regression to examine the associations between BRFs, ascertained through validated questionnaires, and the prevalence of multimorbidity, defined as having two or more of 13 common chronic conditions. We used latent class analysis (LCA) to investigate common patterns of multimorbidity, followed by multinomial logistic regression to examine their associations with BRFs (categorised as binary), adjusted for age, sex, and household socioeconomic status. Of 5332 adult participants (mean age 35.5 years, standard deviation 13.8 years) included in the analysis, 14.2% had multimorbidity, the prevalence of which increased steeply with age. Current tobacco consumption (adjusted odds ratio (aOR) = 1.23 [95% confidence interval (CI): 1.01-1.50]), physical inactivity (aOR: 1.66 [95% CI: 1.38-1.99]), and poor sleep (aOR: 1.86 [95% CI: 1.35-2.57]) were associated with higher odds of having multimorbidity. We found one multimorbidity pattern of "anaemia and hypertension" (n = 220, 4.1%). Physical inactivity (aOR: 2.07 [95% CI: 1.52-2.82]) was associated with higher odds of having this multimorbidity pattern, with no associations found for the other BRFs. The BRFs identified, notably physical activity, could present important opportunities for intervention to reduce the burden of multimorbidity in India. Longitudinal studies are needed to confirm these relationships. CI - Copyright: (c) 2026 Song et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Song, Wenbo AU - Song W AUID- ORCID: 0000-0002-1588-8597 AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. AD - School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan. AD - Department of Methodology, London School of Economics & Political Science, London, United Kingdom. FAU - Lieber, Judith AU - Lieber J AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. FAU - Yamanashi, Hirotomo AU - Yamanashi H AD - School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan. AD - Department of General Medicine, Nagasaki University, Nagasaki, Japan. FAU - Matsuzaki, Mika AU - Matsuzaki M AD - Department of International Health, Johns Hopkins University, Baltimore, Maryland, United States of America. FAU - Lewin, Alex AU - Lewin A AUID- ORCID: 0000-0003-0081-7582 AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. FAU - Gittelsohn, Joel AU - Gittelsohn J AD - Department of International Health, Johns Hopkins University, Baltimore, Maryland, United States of America. FAU - Hazell, Matthew AU - Hazell M AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. FAU - Banjara, Santosh Kumar AU - Banjara SK AUID- ORCID: 0000-0002-0893-9552 AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. FAU - Mahajan, Hemant AU - Mahajan H AUID- ORCID: 0000-0001-7874-9191 AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. FAU - Bhogadi, Santhi AU - Bhogadi S AUID- ORCID: 0000-0002-7713-8804 AD - Indian Institute of Public Health, Bengaluru, India. FAU - Addanki, Srivalli AU - Addanki S AD - Indian Institute of Public Health, Bengaluru, India. FAU - Kurmi, Om AU - Kurmi O AD - Centre for Healthcare and Communities, Coventry University, Coventry, United Kingdom. FAU - Iyer, Gowri AU - Iyer G AD - Indian Institute of Public Health, Bengaluru, India. FAU - Kamalakannan, Sureshkumar AU - Kamalakannan S AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. AD - School of Communities and Education, Northumbria University, Newcastle Upon Tyne, United Kingdom. FAU - Sadanand, Shilpa AU - Sadanand S AUID- ORCID: 0000-0002-2097-2187 AD - Indian Institute of Public Health, Bengaluru, India. FAU - Kulkarni, Bharati AU - Kulkarni B AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. AD - Indian Council of Medical Research, New Delhi, India. FAU - Kinra, Sanjay AU - Kinra S AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. FAU - Mallinson, Poppy A C AU - Mallinson PAC AD - Department of Non-communicable Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, United Kingdom. LA - eng GR - WT_/Wellcome Trust/United Kingdom PT - Journal Article DEP - 20260730 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC13422877 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/30 18:36 MHDA- 2026/07/30 18:37 PMCR- 2026/07/30 CRDT- 2026/07/30 13:43 PHST- 2025/08/11 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/07/30 18:37 [medline] PHST- 2026/07/30 18:36 [pubmed] PHST- 2026/07/30 13:43 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - PGPH-D-25-01731 [pii] AID - 10.1371/journal.pgph.0006694 [doi] PST - epublish SO - PLOS Glob Public Health. 2026 Jul 30;6(7):e0006694. doi: 10.1371/journal.pgph.0006694. eCollection 2026. PMID- 42530761 OWN - NLM STAT- MEDLINE DCOM- 20260928 LR - 20261008 IS - 1613-9674 (Electronic) IS - 0911-6028 (Linking) VI - 42 IP - 4 DP - 2026 Oct TI - Application of a novel age estimation model based on permanent maxillary canine morphometric features in a Japanese population. PG - 1121-1131 LID - 10.1007/s11282-026-00952-4 [doi] AB - OBJECTIVES: This study aims to clarify the growth curves of the long axis and apical foramen diameter of permanent maxillary canines (PMCs), and to create and evaluate a new nonlinear age estimation (NAGE) model by integrating their inverse functions within a machine learning framework. METHODS: CT measurements of length (L), apical shortest width (SW) and longest width (LW) were obtained from 726 PMCs (aged 1 to 23 years). Growth curves were modeled using Gompertz function for L and Gamma-type function for SW and LW. Inverse functions were integrated into the NAGE model: [Formula: see text]. Parameters were optimized using Soft-L1 robust least squares (SciPy, NumFOCUS, USA). Validation applied to 14 independent longitudinal cases (75 PMCs, 3-15 years). Agreement between predicted age (PA) and chronological age (CA) was evaluated using root mean squared error (RMSE), coefficient of determination (R(2)), and Wilcoxon signed-rank test. RESULTS: The Gompertz and Gamma-type functions effectively captured PMC growth, with RMSE of 2.5 mm (L), 1.07 mm (SW), and 1.45 mm (LW). The NAGE achieved RMSE of 1.89 years (R(2) = 0.85) in the 1-23 years group, improving to 1.29 years (R(2) = 0.89) in the 1-16 years group. In longitudinal cases, the overall mean difference between PA and CA was 0.12 years (1.4 months) with an RMSE of 0.99 years (R(2) = 0.86) and individual errors ranging from 0.25 to 2.09 years. CONCLUSIONS: The proposed NAGE model showed promising performance for dental age estimation based on PMC length and apical foramen widths. Further studies in other teeth are needed. CI - (c) 2026. The Author(s) under exclusive licence to Japanese Society for Oral and Maxillofacial Radiology. FAU - Prakoeswa, Beshlina Fitri Widayanti Roosyanto AU - Prakoeswa BFWR AD - Division of Oral and Maxillofacial Radiology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Dentistry and Health Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo- ku, Niigata, 951-8514, Japan. AD - Department of Forensic Odontology, Faculty of Dental Medicine Universitas Airlangga, Surabaya, 60132, Indonesia. FAU - Nishiyama, Hideyoshi AU - Nishiyama H AD - Division of Oral and Maxillofacial Radiology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Dentistry and Health Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo- ku, Niigata, 951-8514, Japan. nisiyama@dent.niigata-u.ac.jp. FAU - Kobayashi, Taichi AU - Kobayashi T AD - Division of Oral and Maxillofacial Radiology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Dentistry and Health Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo- ku, Niigata, 951-8514, Japan. FAU - Ike, Makiko AU - Ike M AD - Division of Oral and Maxillofacial Radiology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Dentistry and Health Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo- ku, Niigata, 951-8514, Japan. FAU - Takamura, Masaki AU - Takamura M AD - Division of Oral and Maxillofacial Radiology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Dentistry and Health Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo- ku, Niigata, 951-8514, Japan. FAU - Nikkuni, Yutaka AU - Nikkuni Y AD - Division of Oral and Maxillofacial Radiology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Dentistry and Health Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo- ku, Niigata, 951-8514, Japan. FAU - Katsura, Kouji AU - Katsura K AD - Division of Oral and Maxillofacial Radiology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Dentistry and Health Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo- ku, Niigata, 951-8514, Japan. FAU - Vo, Diem T AU - Vo DT AD - Division of Oral and Maxillofacial Radiology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Dentistry and Health Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo- ku, Niigata, 951-8514, Japan. FAU - Hayashi, Takafumi AU - Hayashi T AD - Division of Oral and Maxillofacial Radiology, Faculty of Dentistry & Graduate School of Medical and Dental Sciences, Dentistry and Health Sciences, Niigata University, 2-5274 Gakkocho-dori, Chuo- ku, Niigata, 951-8514, Japan. LA - eng PT - Journal Article DEP - 20260730 PL - Japan TA - Oral Radiol JT - Oral radiology JID - 8806621 RN - Japanese people SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Young Adult MH - *Age Determination by Teeth/methods MH - *Cuspid/growth & development/diagnostic imaging/anatomy & histology MH - Japan/ethnology MH - Machine Learning MH - Maxilla MH - Tomography, X-Ray Computed/methods MH - East Asian People OTO - NOTNLM OT - Age determination by teeth OT - Computed tomography OT - Machine learning OT - Maxillary canine OT - Morphometry COIS- Declarations. Conflict of interest: All authors declare no conflicts of interest. Ethical approval: This study was conducted in the Division of Oral and Maxillofacial Radiology of Niigata University, Japan and approved by the ethical review committee (approval No: 2023 - 0330). EDAT- 2026/07/30 12:43 MHDA- 2026/09/29 05:30 CRDT- 2026/07/30 11:19 PHST- 2026/05/11 00:00 [received] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/09/29 05:30 [medline] PHST- 2026/07/30 12:43 [pubmed] PHST- 2026/07/30 11:19 [entrez] AID - 10.1007/s11282-026-00952-4 [pii] AID - 10.1007/s11282-026-00952-4 [doi] PST - ppublish SO - Oral Radiol. 2026 Oct;42(4):1121-1131. doi: 10.1007/s11282-026-00952-4. Epub 2026 Jul 30. PMID- 42530682 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260813 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 8 DP - 2026 Jul 30 TI - Pediatric eosinophilic esophagitis: diagnostic and therapeutic insights from a 15-year retrospective study. LID - 10.1007/s00431-026-07270-1 [doi] LID - 626 AB - Eosinophilic Esophagitis (EoE) is a chronic inflammatory disorder with variable macroscopic and microscopic findings and clinical presentations, complicating management. This study examines esophageal sampling practices, segmental disease patterns, and longitudinal treatment trends and outcomes in pediatric EoE. We retrospectively reviewed charts of 138 pediatric EoE patients diagnosed between 2009 and 2023. EoE was defined as compatible symptoms and >/= 15 eosinophils per high-power-field without alternative explanation. Diagnostic endoscopy was defined as the first endoscopy performed for evaluation of symptoms showing >/= 15 eosinophils. Data included demographics, symptoms, macroscopic/microscopic findings, sampling methods, and treatments. Mean age at diagnosis was 8.33 +/- 5.37 years, 75% male. Most common presenting symptoms were vomiting (39.28%), dysphagia (32.14%) and food impaction (28.57%). Among 112 diagnostic endoscopies, macroscopic abnormalities were most frequent in the lower esophagus (85.71%), with furrows (69.64%) and exudates (55.36%) predominating. Multi-level sampling in patients with >/= 15 eosinophils in one field, revealed < 15 eosinophils in 21.11% of upper, 7.14% of middle, and 14.14% of lower esophageal samples. Microscopic findings despite normal endoscopic appearance were most common in the upper (26.4%, p < 0.001), and less frequently in the lower (9.8% p = 0.002) esophagus. Remission following first-line therapy was achieved in 44 patients (48.35%). Biologic therapy was initiated after multiple prior treatment failures and resulted in histologic remission in all treated patients (n = 9). CONCLUSIONS: Findings indicate greater disease severity distally and underscore the need for multi-regional sampling, even in normal-appearing areas. Therapeutic responses are heterogenous and limited, and biologic therapies show promise but require validation in larger studies. WHAT IS KNOWN: * Pediatric eosinophilic esophagitis (EoE) is a chronic immune-mediated disease with variable endoscopic findings, requiring both compatible clinical features and histologic evidence of >/=15 eosinophils per high-power field. * Empiric elimination diets and proton pump inhibitors are considered first-line treatments, with variable remission rates. WHAT IS NEW: * Pan-esophageal multi-level biopsies, including from normal-appearing mucosa, improve diagnostic accuracy. * While first-line therapies show mild success rates, real-world data demonstrate complete histologic remission with biologic therapy, supporting its promise for pediatric EoE. CI - (c) 2026. The Author(s). FAU - Greenberger, Sraya AU - Greenberger S AD - Pediatric Gastroenterology, Hepatology and Nutrition, The Hadassah Medical Organization, Jerusalem, Israel. AD - "Tzameret" Program, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. FAU - Davidovics, Zev AU - Davidovics Z AD - Pediatric Gastroenterology, Hepatology and Nutrition, The Hadassah Medical Organization, Jerusalem, Israel. AD - Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. FAU - Milman, Peri AU - Milman P AD - Pediatric Gastroenterology, Hepatology and Nutrition, The Hadassah Medical Organization, Jerusalem, Israel. AD - Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. FAU - Orgad, Tamar AU - Orgad T AD - Pediatric Gastroenterology, Hepatology and Nutrition, The Hadassah Medical Organization, Jerusalem, Israel. FAU - Haimov, Elinor AU - Haimov E AD - Pediatric Gastroenterology, Hepatology and Nutrition, The Hadassah Medical Organization, Jerusalem, Israel. FAU - Reif, Shimon AU - Reif S AD - Pediatric Gastroenterology, Hepatology and Nutrition, The Hadassah Medical Organization, Jerusalem, Israel. AD - Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. FAU - Pappo, Orit AU - Pappo O AD - Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. AD - Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. FAU - Elia, Anna AU - Elia A AD - Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. AD - Department of Pathology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. FAU - Wilschanski, Michael AU - Wilschanski M AD - Pediatric Gastroenterology, Hepatology and Nutrition, The Hadassah Medical Organization, Jerusalem, Israel. AD - Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. FAU - Slae, Mordechai AU - Slae M AD - Pediatric Gastroenterology, Hepatology and Nutrition, The Hadassah Medical Organization, Jerusalem, Israel. AD - Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. FAU - Birimberg-Schwartz, Liron AU - Birimberg-Schwartz L AD - Pediatric Gastroenterology, Hepatology and Nutrition, The Hadassah Medical Organization, Jerusalem, Israel. lbschwartz@hadassah.org.il. AD - Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. lbschwartz@hadassah.org.il. LA - eng PT - Journal Article DEP - 20260730 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 0 (Proton Pump Inhibitors) SB - IM MH - Humans MH - *Eosinophilic Esophagitis/diagnosis/therapy/pathology MH - Retrospective Studies MH - Male MH - Female MH - Child MH - Esophagoscopy MH - Child, Preschool MH - Esophagus/pathology MH - Adolescent MH - Eosinophils MH - Proton Pump Inhibitors/therapeutic use PMC - PMC13424580 OTO - NOTNLM OT - Endoscopy OT - Eosinophilic Esophagitis OT - Histology OT - Management COIS- Declarations. Ethical approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Hadassah University Medical Center (Date: 26/10/2023 No: HMO-0326-23). Informed consent was waived due to the study's retrospective observational nature. Competing interests: The authors declare no competing interests. EDAT- 2026/07/30 12:43 MHDA- 2026/07/30 12:44 PMCR- 2026/07/30 CRDT- 2026/07/30 11:16 PHST- 2026/04/30 00:00 [received] PHST- 2026/07/18 00:00 [accepted] PHST- 2026/07/14 00:00 [revised] PHST- 2026/07/30 12:44 [medline] PHST- 2026/07/30 12:43 [pubmed] PHST- 2026/07/30 11:16 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - 10.1007/s00431-026-07270-1 [pii] AID - 7270 [pii] AID - 10.1007/s00431-026-07270-1 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jul 30;185(8):626. doi: 10.1007/s00431-026-07270-1. PMID- 42529941 OWN - NLM STAT- Publisher LR - 20260730 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) DP - 2026 Jul 30 TI - Functional roles and nutritional potential of human milk oligosaccharides in swine gut health. PG - 1-44 LID - 10.1017/S0007114526107776 [doi] AB - Human milk oligosaccharides (HMOs) are a prominent class of bioactive glycans recognized for their pivotal roles as prebiotics, anti-adhesive antimicrobials, and immunomodulators in neonatal development. While traditionally studied in the context of infant nutrition, scalable biotechnological production now allows for their evaluation in swine production to address the relatively lower structural complexity of the porcine milk glycome compared to humans. This review critically evaluates the structural diversity and biosynthesis of HMOs, detailing how specific fucosylated and sialylated structures modulate the porcine gut microbiome and reinforce intestinal barrier integrity. We synthesize current evidence regarding the metabolic fate of these glycans in the piglet and address the translational relevance of using swine as high-fidelity models for human gastrointestinal physiology. Furthermore, the review identifies critical knowledge gaps, specifically the lack of large-scale longitudinal studies and comprehensive cost-benefit analyses required to validate the economic feasibility of HMOs in commercial agriculture. By consolidating these mechanistic insights within the context of global efforts to reduce reliance on antibiotic growth promoters, this work underscores the potential of HMOs as precision nutritional tools to enhance resilience and productivity in sustainable animal production systems. FAU - El Bouhi, Romaissaa AU - El Bouhi R AD - College of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, China621010. FAU - Hu, Qinfeng AU - Hu Q AD - College of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, China621010. FAU - Zhong, Jie AU - Zhong J AD - College of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, China621010. FAU - Zhou, Pan AU - Zhou P AD - College of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, China621010. FAU - Zhang, Yong AU - Zhang Y AD - College of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, China621010. FAU - Liu, Lingbin AU - Liu L AD - College of Animal Science and Technology, Chongqing Key Laboratory of Herbivore Science, Southwest University, Beibei, 400700, Chongqing, China. FAU - Yan, Honglin AU - Yan H AUID- ORCID: 0000-0002-2597-6902 AD - College of Life Science and Agri-forestry, Southwest University of Science and Technology, Mianyang, China621010. LA - eng PT - Journal Article PT - Review DEP - 20260730 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM OTO - NOTNLM OT - gut microbiota OT - human milk oligosaccharides OT - immune modulation OT - intestinal health OT - piglet health OT - prebiotics OT - swine nutrition EDAT- 2026/07/30 12:43 MHDA- 2026/07/30 12:43 CRDT- 2026/07/30 06:23 PHST- 2026/07/30 12:43 [medline] PHST- 2026/07/30 12:43 [pubmed] PHST- 2026/07/30 06:23 [entrez] AID - S0007114526107776 [pii] AID - 10.1017/S0007114526107776 [doi] PST - aheadofprint SO - Br J Nutr. 2026 Jul 30:1-44. doi: 10.1017/S0007114526107776. PMID- 42529401 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260730 LR - 20260824 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Beyond the game: evaluating a soccer-centered approach to physical activity and health education in children. PG - 1765167 LID - 10.3389/fspor.2026.1765167 [doi] LID - 1765167 AB - BACKGROUND/OBJECTIVES: Due to only 25% of U.S. children meeting the physical activity guidelines, we aimed to determine feasibility of team sports to engage children in at least 60 min of moderate-to-vigorous physical activity daily and increase health knowledge. METHODS: This 11-week quasi-experimental pre/post intervention study was conducted in two after-school programs around metro Atlanta, GA, USA (C1, n = 18; C2, n = 22). The 11 for Health program is an 11-week active learning model that involves 2 x 45 min per week soccer drills, small-sided games, and health education modules. Assessments included health knowledge and physical fitness metrics such as estimated VO(2), standing long jump, balance, agility, and handgrip strength. Non-participants were defined as missing 3 or more sessions and/or not participating in the activities. Descriptive statistics and t-tests were used to compare pre- and post-intervention assessments, stratified by participation level. RESULTS: C1 were on average 9.2 years old, 31% female, and 100% White. C2 were on average 9.8 years, 48% female, and 67% Hispanic and 33% Black. Attendance was 69% (SD 0.26) in average over the 11 weeks for both cohorts, with no difference in attendance between groups. Agility improved significantly [2.7 s(1.5); 95% CI: -3.2,-2.2] overall but no between-group difference was found. C2 participants improved significantly compared to C1 participants (p = 0.006) in left handgrip. C1 performed significantly better on the health knowledge test (p = 0.023; 95% CI: 0.018, 0.225) but neither cohort improved over time. CONCLUSION: The program is feasible for American children; however, careful consideration of setting and coaching staff is necessary. CI - (c) 2026 Foster, Li, Juarez, Pelkmans, Fluellen, Li, Lee, Munoz, Rohith, Krustrup, Larsen and Frediani. FAU - Foster, Jordan D AU - Foster JD AD - Rollins School of Public Health, Emory University, Atlanta, GA, United States. FAU - Li, Eva AU - Li E AD - Emory College of Arts and Humanities, Emory University, Atlanta, GA, United States. FAU - Juarez, Arturo Jr AU - Juarez A Jr AD - Emory College of Arts and Humanities, Emory University, Atlanta, GA, United States. FAU - Pelkmans, Jordan AU - Pelkmans J AD - Nell Woodruff Hodgson School of Nursing, Emory University, Atlanta, GA, United States. FAU - Fluellen, Staci AU - Fluellen S AD - School of Public Health, Georgia State University, Atlanta, GA, United States. FAU - Li, Kevin AU - Li K AD - Emory College of Arts and Humanities, Emory University, Atlanta, GA, United States. FAU - Lee, Jocelyn AU - Lee J AD - Emory College of Arts and Humanities, Emory University, Atlanta, GA, United States. FAU - Munoz, Leilany AU - Munoz L AD - Nell Woodruff Hodgson School of Nursing, Emory University, Atlanta, GA, United States. FAU - Rohith, Siddhanth AU - Rohith S AD - Alliance Academy for Innovation, Cumming, GA, United States. FAU - Krustrup, Peter AU - Krustrup P AD - Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. AD - Sport and Health Sciences, University of Exeter, Exeter, United Kingdom. FAU - Larsen, Malte N AU - Larsen MN AD - Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Frediani, Jennifer K AU - Frediani JK AD - Nell Woodruff Hodgson School of Nursing, Emory University, Atlanta, GA, United States. LA - eng GR - P30 DK111024/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20260715 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13417902 OTO - NOTNLM OT - association football OT - children OT - health knowledge OT - health literacy OT - physical fitness OT - soccer COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/30 06:41 MHDA- 2026/07/30 06:42 PMCR- 2026/07/15 CRDT- 2026/07/30 05:03 PHST- 2025/12/10 00:00 [received] PHST- 2026/04/13 00:00 [revised] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/07/30 06:42 [medline] PHST- 2026/07/30 06:41 [pubmed] PHST- 2026/07/30 05:03 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.3389/fspor.2026.1765167 [doi] PST - epublish SO - Front Sports Act Living. 2026 Jul 15;8:1765167. doi: 10.3389/fspor.2026.1765167. eCollection 2026. PMID- 42528895 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260730 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Predicting serum phosphate levels in very preterm infants using machine learning. PG - 1881474 LID - 10.3389/fped.2026.1881474 [doi] LID - 1881474 AB - BACKGROUND: Hypophosphatemia in very preterm and small for gestational age (SGA) infants is common and associated with serious complications. Diagnosis relies on phosphate concentrations, measured in serum or plasma. Machine learning (ML) may enable indirect estimation of serum phosphate based on routinely collected clinical data and results from blood gas analysis. OBJECTIVES: To (1) describe first week electrolyte trajectories in the ImNuT-trial (Clinicaltrials.gov ID: NCT03555019), and (2) develop and externally validate ML models to estimate serum phosphate levels during the first postnatal week in very preterm infants, using routinely collected clinical and nutritional data. METHODS: We performed a retrospective analysis of 120 infants born <29 weeks' gestation, all managed under a standardized nutritional protocol. Electrolyte trajectories (calcium, potassium, sodium, phosphate) were described using daily means stratified by hypophosphatemia and SGA status. For ML, we defined three regression tasks: concurrent phosphate prediction at blood gas analysis, and forecasts 12 h and 24 h ahead. Twenty-two candidate predictors from blood gases, anthropometry, SGA status and nutrient intakes were subjected to RENT-based variable selection within leave-one-group-out cross-validation. Multiple algorithms (elastic net, gradient boosting, random forests, k-nearest neighbours, kernel ridge, XGBoost) were trained under three preprocessing strategies (complete cases, complete cases without outliers, imputed data). Performance was evaluated with RMSE and R (2) using nested cross-validation and an independent external cohort of 40 very preterm infants. RESULTS: Among 119 infants with phosphate measurements (607 samples), 33.6% developed hypophosphatemia in week one. SGA infants had a markedly higher and earlier risk of hypophosphatemia compared to appropriate-for-gestational-age infants (log-rank p < 0.0001). Six predictors (calcium, potassium, gestational age, SGA status, birth weight z-score, daily weight z-score) were consistently retained across all prediction tasks. Elastic net models performed best externally on all three prediction tasks. Performance was robust across preprocessing strategies. CONCLUSIONS: SGA status is a major determinant of early hypophosphatemia risk in very preterm infants. ML models using routinely available clinical and nutritional data can moderately but consistently estimate serum phosphate levels, including 12-24 h ahead, and may serve as screening tools to guide nutritional management and reduce unnecessary blood sampling. Prospective validation is warranted before clinical implementation. CI - (c) 2026 Westvik, Tomic, Tscherning and Moltu. FAU - Westvik, Asbjorn S AU - Westvik AS AD - Institute of Clinical Medicine, University of Oslo, Oslo, Norway. AD - Department of Neonatal Intensive Care, Oslo University Hospital, Oslo, Norway. FAU - Tomic, Oliver AU - Tomic O AD - Faculty of Science and Technology, Norwegian University of Life Sciences, As, Norway. FAU - Tscherning, Charlotte AU - Tscherning C AD - Institute of Clinical Medicine, University of Oslo, Oslo, Norway. AD - Department of Neonatal Intensive Care, Oslo University Hospital, Oslo, Norway. FAU - Moltu, Sissel J AU - Moltu SJ AD - Department of Neonatal Intensive Care, Oslo University Hospital, Oslo, Norway. LA - eng SI - ClinicalTrials.gov/NCT03555019 PT - Journal Article DEP - 20260715 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13415508 OTO - NOTNLM OT - hypophosphatemia OT - machine learning OT - prediction model OT - preterm infant OT - refeeding syndrome COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/30 06:41 MHDA- 2026/07/30 06:42 PMCR- 2026/07/15 CRDT- 2026/07/30 04:48 PHST- 2026/05/14 00:00 [received] PHST- 2026/06/29 00:00 [revised] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/07/30 06:42 [medline] PHST- 2026/07/30 06:41 [pubmed] PHST- 2026/07/30 04:48 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.3389/fped.2026.1881474 [doi] PST - epublish SO - Front Pediatr. 2026 Jul 15;14:1881474. doi: 10.3389/fped.2026.1881474. eCollection 2026. PMID- 42528788 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Prepregnancy body mass index and risk of macrosomia after fresh embryo transfer: a retrospective cohort study with exploratory threshold analysis. PG - 1884067 LID - 10.3389/fendo.2026.1884067 [doi] LID - 1884067 AB - BACKGROUND: Higher prepregnancy body mass index (BMI) is a well-established risk factor for adverse neonatal outcomes in IVF-conceived pregnancies; therefore, weight management is important for infertile patients, yet it remains challenging. Determining a clinically applicable BMI threshold for neonatal outcome risk assessment in fresh embryo transfer (fresh ET) cycles is meaningful; however, it remains undetermined. Therefore, this study aimed to identify an exploratory BMI threshold associated with increased risk of adverse neonatal outcomes after fresh ET, providing a preliminary reference for clinical risk communication. METHODS: This retrospective cohort study included 2,195 women who underwent autologous fresh ET between June 2019 and December 2023. Multivariable regression analysis examined the association between prepregnancy BMI and neonatal outcomes. Smooth curve fitting and threshold effect analysis identified the exploratory BMI threshold. Adjusted analysis following propensity score matching (PSM) was conducted as a sensitivity analysis to validate the robustness of the results. RESULTS: The multivariate regression analyses revealed that birthweight (adjusted beta: 22.63, 95% CI: 14.53 to 30.73; P<0.001) and Z-score (adjusted beta: 0.06, 95% CI: 0.04 to 0.08; P<0.001) were positively associated with increasing maternal BMI. Compared with the reference group (BMI 18.5-24.9 kg/m(2)), the incidence of macrosomia was increased by 2.25-fold in the BMI 25-29.9 kg/m(2) group (adjusted OR: 2.25, 95% CI: 1.29 to 3.93; P = 0.004) and by 4.56-fold in the BMI >/=30 kg/m(2) group (adjusted OR: 4.56, 95% CI: 2.26 to 9.22; P<0.001). Smooth curve fitting and threshold effect analysis revealed a significant increase in the odds of macrosomia when BMI exceeded 26.22 kg/m(2) (adjusted OR: 4.05, 95% CI: 2.47 to 7.29; P = 0.0009). PSM analysis confirmed that patients with a BMI >26.22 kg/m(2) (adjusted OR: 3.01, 95% CI: 2.02 to 4.47; P<0.001) had significantly higher odds of macrosomia compared to those with BMI .90, CV < 5%) repeatability, although the ASH test demonstrated good-to-excellent relative repeatability (ICC = .87-.90) but greater absolute variability (CV > 10%). CONCLUSION: CMJ and ballistic push-up testing on a force plate are suitable for athlete monitoring in competitive swimming. The ASH test demonstrated greater variability between sessions, highlighting the need for further evaluation prior to its integration into athlete monitoring assessments. FAU - McKenzie, Mark AU - McKenzie M AUID- ORCID: 0009-0005-7326-3535 AD - Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. AD - Integrative Neuromuscular Sport Performance Lab, Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. FAU - Boon-van Mossel, Nathan AU - Boon-van Mossel N AUID- ORCID: 0009-0007-2948-0131 AD - Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. AD - Integrative Neuromuscular Sport Performance Lab, Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. FAU - McClean, Zachary J AU - McClean ZJ AUID- ORCID: 0000-0002-7219-9448 AD - Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. AD - Integrative Neuromuscular Sport Performance Lab, Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. FAU - Jordan, Matthew J AU - Jordan MJ AUID- ORCID: 0000-0002-8044-1441 AD - Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. AD - Integrative Neuromuscular Sport Performance Lab, Faculty of Kinesiology,University of Calgary, Calgary, AB, Canada. AD - Sport Medicine Centre, University of Calgary, Calgary, AB, Canada. LA - eng PT - Journal Article DEP - 20260729 PL - United States TA - Int J Sports Physiol Perform JT - International journal of sports physiology and performance JID - 101276430 SB - IM MH - Humans MH - *Swimming/physiology/injuries MH - Female MH - Reproducibility of Results MH - *Muscle Strength/physiology MH - *Exercise Test/methods MH - Male MH - Young Adult MH - Canada MH - Return to Sport MH - *Shoulder/physiology MH - Universities MH - Adolescent OTO - NOTNLM OT - athletic shoulder test OT - countermovement jump OT - push-up OT - shoulder girdle OT - strength assessment EDAT- 2026/07/30 00:38 MHDA- 2026/09/29 19:03 CRDT- 2026/07/29 19:32 PHST- 2025/11/03 00:00 [received] PHST- 2026/04/01 00:00 [revised] PHST- 2026/04/10 00:00 [accepted] PHST- 2026/09/29 19:03 [medline] PHST- 2026/07/30 00:38 [pubmed] PHST- 2026/07/29 19:32 [entrez] AID - 10.1123/ijspp.2025-0499 [doi] PST - epublish SO - Int J Sports Physiol Perform. 2026 Jul 29;21(10):1198-1202. doi: 10.1123/ijspp.2025-0499. Print 2026 Oct 1. PMID- 42526856 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261027 IS - 1543-5474 (Electronic) IS - 1543-3080 (Linking) VI - 23 IP - 11 DP - 2026 Nov 1 TI - Parent-Reported 24-Hour Movement Behaviors and Executive Functions for Preschool Children: Evidence From Iraq. PG - 1697-1704 LID - 10.1123/jpah.2026-0141 [doi] AB - BACKGROUND: Growing evidence highlights the importance of 24-hour movement behaviors for children's executive functions. However, evidence from Arab countries, particularly Iraq, remains limited. METHODS: A cross-sectional sample of 210 preschool children (4-6 y old) was randomly selected from 14 kindergartens in Samarra, Iraq during the 2025-2026 academic year. Daily time spent in light, moderate, and vigorous physical activity; sedentary behavior; recreational screen time; and sleep duration was reported by parents using an Arabic 24-hour time log with acceptable internal consistency (Cronbach alpha = .77). Executive functions were measured using the Head-Toes-Knees-Shoulders Revised task. Pearson correlations were used as descriptive indicators, and multiple regression and compositional data analysis using isometric log-ratio balances were applied for inferential interpretation. RESULTS: Head-Toes-Knees-Shoulders Revised scores were positively associated with moderate to vigorous physical activity and sleep duration and negatively associated with sedentary behavior and recreational screen time (all P < .001). Compositional data analysis showed that isometric log-ratio balances representing moderate to vigorous physical activity relative to remaining behaviors, as well as sleep relative to waking behaviors, were significantly associated with higher Head-Toes-Knees-Shoulders Revised scores (P < .001). In contrast, the balance between screen time and nonscreen sedentary behavior was not statistically significant. CONCLUSIONS: A balanced daily routine, characterized by active movement, sufficient sleep, and limited screen time, was associated with better executive function performance in early childhood. FAU - Ibrahim, Abdelrahman AU - Ibrahim A AUID- ORCID: 0000-0003-1600-4404 AD - College of Physical Education and Sport Sciences, University of Samarra, Samarra, Iraq. FAU - Hawar, Ali Burhan AU - Hawar AB AUID- ORCID: 0009-0003-5148-6290 AD - College of Physical Education and Sport Sciences, University of Kirkuk, Kirkuk, Iraq. FAU - Jebur, Mohammed Saad AU - Jebur MS AUID- ORCID: 0009-0003-0927-0912 AD - College of Physical Education and Sport Sciences, University of Tikrit, Tikrit, Iraq. FAU - Ahmed, Mayada H AU - Ahmed MH AUID- ORCID: 0009-0008-9178-4870 AD - College of Physical Education and Sport Sciences, University of Samarra, Samarra, Iraq. FAU - Alsamarae, Mohammed Saleh Khaleel AU - Alsamarae MSK AUID- ORCID: 0000-0002-1353-973X AD - College of Physical Education and Sport Sciences, University of Samarra, Samarra, Iraq. LA - eng PT - Journal Article DEP - 20260728 PL - United States TA - J Phys Act Health JT - Journal of physical activity & health JID - 101189457 SB - IM MH - Humans MH - *Executive Function/physiology MH - Child, Preschool MH - Female MH - Cross-Sectional Studies MH - Male MH - Sedentary Behavior MH - Sleep Duration MH - *Exercise/physiology MH - Iraq MH - Parents MH - Screen Time MH - Child MH - Sleep OTO - NOTNLM OT - moderate to vigorous physical activity OT - recreational screen exposure OT - sedentary behavior OT - self-regulation OT - sleep health EDAT- 2026/07/30 00:38 MHDA- 2026/10/27 17:29 CRDT- 2026/07/29 19:32 PHST- 2026/02/24 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/10/27 17:29 [medline] PHST- 2026/07/30 00:38 [pubmed] PHST- 2026/07/29 19:32 [entrez] AID - 10.1123/jpah.2026-0141 [doi] PST - epublish SO - J Phys Act Health. 2026 Jul 28;23(11):1697-1704. doi: 10.1123/jpah.2026-0141. Print 2026 Nov 1. PMID- 42525668 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Healthcare providers' perspectives and needs related to the management of Pediatric Feeding Disorder: A focus group study. PG - e0354724 LID - 10.1371/journal.pone.0354724 [doi] LID - e0354724 AB - Pediatric feeding disorder is a prevalent, impactful diagnosis for children and their families. This diagnosis is heterogenous in presentation and requires the care of a multidisciplinary team of providers. Existing research suggests providers are underprepared to assess and treat pediatric feeding disorder, therefore more information on training and clinical practice is needed. This study conducted focus groups to describe the training journey of providers across all four pediatric feeding disorder domains (medical, nutrition, feeding skill, psychosocial). Seven focus groups (total of 25 providers) were conducted and analyzed using thematic analysis. Four themes were identified: differences in academic preparation, workplace infrastructure and access, desire for comprehensiveness and feasibility, and value of the family perspective. Overall, results point to opportunities to improve provider training and therefore patient care including academic exposure to pediatric feeding disorder and multi-disciplinary collaboration practices, increased access to mentorship, training, and evidenced-based resources, and enrichment of the research to practice pipeline with a focus on family-centered care. CI - Copyright: (c) 2026 Thompson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Thompson, Kelsey AU - Thompson K AUID- ORCID: 0000-0002-3309-9516 AD - Division of Speech and Hearing Sciences, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. FAU - Romeo, Cuyler AU - Romeo C AD - Feeding Matters, Phoenix, Arizona, United States of America. AD - Banner University Medical Center - Tucson, Tucson, Arizona, United States of America. FAU - Simione, Meg AU - Simione M AD - Department of Communicative Disorders, University of Rhode Island, Kingston, Rhode Island, United States of America. FAU - Estrem, Hayley AU - Estrem H AUID- ORCID: 0000-0003-2599-8893 AD - School of Nursing, University of North Carolina at Wilmington, Wilmington, North Carolina, United States of America. FAU - Pederson, Jaclyn L AU - Pederson JL AD - Feeding Matters, Phoenix, Arizona, United States of America. FAU - Sharp, William G AU - Sharp WG AD - Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, United States of America. AD - Multidisciplinary Feeding Program, Children's Healthcare of Atlanta, Atlanta, Georgia, United States of America. LA - eng PT - Journal Article DEP - 20260729 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Focus Groups MH - *Health Personnel/psychology/education MH - *Feeding and Eating Disorders of Childhood/therapy MH - Child MH - Female MH - *Attitude of Health Personnel PMC - PMC13419198 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/29 18:39 MHDA- 2026/07/30 00:38 PMCR- 2026/07/29 CRDT- 2026/07/29 13:43 PHST- 2026/03/02 00:00 [received] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/07/30 00:38 [medline] PHST- 2026/07/29 18:39 [pubmed] PHST- 2026/07/29 13:43 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - PONE-D-26-08691 [pii] AID - 10.1371/journal.pone.0354724 [doi] PST - epublish SO - PLoS One. 2026 Jul 29;21(7):e0354724. doi: 10.1371/journal.pone.0354724. eCollection 2026. PMID- 42525667 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Neck circumference as an anthropometric marker of overweight among school-aged children in Bharatpur, Nepal: A community-based study. PG - e0354997 LID - 10.1371/journal.pone.0354997 [doi] LID - e0354997 AB - BACKGROUND: Childhood overweight have become a major public health concern among children in developing countries. BMI, commonly used to diagnose overweight, requires standardized equipment and trained personnel, limiting their feasibility in large-scale screenings. Neck circumference (NC) has emerged as a simple and practical alternative for identifying overweight in children. This study aimed to examine the association between NC and established anthropometric indicators and to determine optimal NC cutoff values for identifying overweight among school-aged children. METHODS: A community-based descriptive cross-sectional study was conducted from July to October 2025 among 300 apparently healthy children aged 6-11 years in Ward No. 16, Bharatpur Metropolitan City, Nepal. Sociodemographic data were collected using structured interviews. Anthropometric measurements including height, weight, NC, waist circumference (WC), and hip circumference (HC) were obtained using standardized procedures. BMI-for-age classifications were based on WHO AnthroPlus growth references. Chi square test, pearson correlation, logistic regression, and receiver operating characteristic (ROC) curve analyses were performed using SPSS version 16. Statistical significance was set at p < 0.05. RESULTS: Among the 300 children, 48.3% had normal BMI-for-age, 10.3% were overweight and 41.3% were underweight. Chi square test revealed a statistically significant association between neck circumference and BMI-for-age (p < 0.001). Pearson correlation analysis demonstrated strong positive correlations between NC and weight (r = 0.792), height (r = 0.639), BMI (r = 0.723), waist circumference (r = 0.797), and hip circumference (r = 0.734) (p < 0.001 for all). ROC curve analysis indicated excellent diagnostic accuracy of NC for identifying overweight. The optimal cutoff values were 27.75 cm for boys (AUC = 0.884; sensitivity = 88.9%; specificity = 66.2%) and 26.75 cm for girls (AUC = 0.904; sensitivity = 100%; specificity = 69.4%). The overall cutoff value was 27.25 cm (AUC = 0.883; sensitivity = 80.6%; specificity = 74.3%). Multivariable logistic regression analysis confirmed NC had a statistically significant positive association with overweight with COR 12.077 (4.75-30.67) and AOR 20.817 (6.34-68.29). CONCLUSIONS: Neck circumference is significantly correlated with established anthropometric indicators and demonstrates diagnostic accuracy for identifying overweight among school-aged children. NC measurement is a simple, reliable, and cost-effective screening tool that may be particularly useful in school-based and resource-limited settings. CI - Copyright: (c) 2026 Bajracharya et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Bajracharya, Subina AU - Bajracharya S AUID- ORCID: 0000-0002-5654-2111 AD - Department of Pediatric Nursing, School of Nursing, Chitwan Medical College, Bharatpur, Nepal. FAU - Neupane, Sadikshya AU - Neupane S AD - Department of Community Health Nursing, School of Nursing, Chitwan Medical College, Bharatpur, Nepal. FAU - Shrestha, Parita AU - Shrestha P AD - Department of Pediatric Nursing, School of Nursing, Chitwan Medical College, Bharatpur, Nepal. LA - eng PT - Journal Article DEP - 20260729 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Nepal/epidemiology MH - Child MH - Male MH - Female MH - *Neck/anatomy & histology MH - Cross-Sectional Studies MH - *Overweight/epidemiology/diagnosis MH - *Anthropometry/methods MH - Body Mass Index MH - ROC Curve MH - Waist Circumference PMC - PMC13419187 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/29 18:39 MHDA- 2026/07/30 00:38 PMCR- 2026/07/29 CRDT- 2026/07/29 13:43 PHST- 2026/04/06 00:00 [received] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/07/30 00:38 [medline] PHST- 2026/07/29 18:39 [pubmed] PHST- 2026/07/29 13:43 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - PONE-D-26-16450 [pii] AID - 10.1371/journal.pone.0354997 [doi] PST - epublish SO - PLoS One. 2026 Jul 29;21(7):e0354997. doi: 10.1371/journal.pone.0354997. eCollection 2026. PMID- 42525244 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261016 IS - 1437-1596 (Electronic) IS - 0937-9827 (Print) IS - 0937-9827 (Linking) VI - 140 IP - 6 DP - 2026 Nov TI - Hybrid approach with convolutional neural network and regression models for age estimation in panoramic radiographs. PG - 3919-3929 LID - 10.1007/s00414-026-03927-6 [doi] AB - BACKGROUND: Determining chronological age is a relevant aspect of criminal and civil interest for identifying corpses and refugees. This study aimed to estimate chronological age using a hybrid model that combines a convolutional neural network (CNN) with regression models based on panoramic radiographs. METHODS: This observational, retrospective and cross-sectional study analyzed 2,546 panoramic radiographs from a Brazilian practice. Panoramic radiographs of patients over 18 years old with healthy, erupted lower premolars were selected. The radiographs were segmented using GIMP, and the dataset was divided into three sets: 70% for model training, 15% for validation, and 15% for testing. Based on the MobileNetV2 architecture, the CNN model extracted 576 attributes from each image, which were then used in conjunction with a decision-tree regression model to estimate age. To evaluate the model's performance, metrics such as Mean Absolute Percentage Error (MAPE), Mean Absolute Error (MAE), Coefficient of Determination and Mean Square Error were used. RESULTS: 3,423 teeth were analyzed, and the patients' mean age was 32.65 years. The overall MAE was 6.52 years (R(2) = 0.67); however, for the age group 31 to 35, the hybrid AI model had an MAE of 0.29 years for the male sample and 0.16 years for the female sample. CONCLUSIONS: The hybrid AI model proved accurate and robust for patients aged 31-35 years; however, in other age groups, the model performed unsatisfactorily, particularly in the 40-50 and 51-55 age ranges. CI - (c) 2026. The Author(s). FAU - Lacerda-Santos, Jhonatan Thiago AU - Lacerda-Santos JT AUID- ORCID: 0000-0003-0295-9939 AD - Department of Dentistry, State University of Paraiba, R. Baraunas, 351, Bairro Universitario, Campina Grande, PB, 58429-500, Brazil. thiiagolacerda@gmail.com. FAU - Paulino, Jose Alberto Souza AU - Paulino JAS AD - Computer Science PhD Student, Federal University of Campina Grande, Rua Aprigio Veloso, 882, Bairro Universitario, Campina Grande, PB, 58429-900, Brazil. FAU - Brito, Hiarles Barreto Sampaio AU - Brito HBS AD - Postgraduate in Oral and Maxillofacial Surgery, State University of Paraiba, R. Baraunas, 351, Bairro Universitario, Campina Grande, PB, 58429-500, Brazil. FAU - Almeida, Fabiana Tolentino AU - Almeida FT AD - College of Dentistry, University of Alberta, 11405 87 Ave NW, Edmonton, AB, T6G 1Z1, Canada. FAU - Bento, Patricia Meira AU - Bento PM AD - College of Dentistry, Department of Dentistry, State University of Paraiba, R. Baraunas, 351, Bairro Universitario, Campina Grande, PB, 58429-500, Brazil. FAU - de Melo, Daniela Pita AU - de Melo DP AD - College of Dentistry, University of Saskatchewan, 105 Wiggins Rd, Saskatoon, SK, S7N 5E5, Canada. LA - eng PT - Journal Article PT - Observational Study DEP - 20260729 PL - Germany TA - Int J Legal Med JT - International journal of legal medicine JID - 9101456 SB - IM MH - Humans MH - *Radiography, Panoramic MH - *Age Determination by Teeth/methods MH - Adult MH - Retrospective Studies MH - *Convolutional Neural Networks MH - Male MH - Regression Analysis MH - Female MH - Cross-Sectional Studies MH - Young Adult MH - Middle Aged MH - Adolescent MH - Brazil MH - *Neural Networks, Computer PMC - PMC13658335 OTO - NOTNLM OT - Age determination by teeth OT - Artificial intelligence OT - Computer Neural Networks OT - Decision trees OT - Panoramic radiography COIS- Declarations. Ethical approval: This study was approved by the Research Ethics Committee of the State University of Paraiba (protocol number 6.700.058) and conducted by the precepts of the Declaration of Helsinki. Informed consent: Not applicable. Competing interests: All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. Clinical trial number: Not applicable. EDAT- 2026/07/29 13:54 MHDA- 2026/10/12 17:30 PMCR- 2026/07/29 CRDT- 2026/07/29 11:13 PHST- 2026/02/07 00:00 [received] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/10/12 17:30 [medline] PHST- 2026/07/29 13:54 [pubmed] PHST- 2026/07/29 11:13 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.1007/s00414-026-03927-6 [pii] AID - 3927 [pii] AID - 10.1007/s00414-026-03927-6 [doi] PST - ppublish SO - Int J Legal Med. 2026 Nov;140(6):3919-3929. doi: 10.1007/s00414-026-03927-6. Epub 2026 Jul 29. PMID- 42525242 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260923 IS - 1432-1459 (Electronic) IS - 0340-5354 (Print) IS - 0340-5354 (Linking) VI - 273 IP - 8 DP - 2026 Jul 29 TI - Prognostic factors in paediatric-onset multiple sclerosis: a narrative review. LID - 10.1007/s00415-026-14029-z [doi] LID - 495 AB - BACKGROUND: Paediatric-onset multiple sclerosis (POMS) accounts for 3-10% of multiple sclerosis (MS) cases and differs from adult-onset disease in course, treatment response and long-term outcomes. Risk stratification is essential, yet the literature frequently conflates three distinct questions: which children develop MS (susceptibility), which convert from a first demyelinating event (conversion) and which, once diagnosed, will accrue disability (prognosis). OBJECTIVE: This study aimed to provide a narrative overview of candidate prognostic factors in POMS, separated from susceptibility and conversion factors and organised by the outcome each predicts. METHODS: PubMed and Google Scholar were searched (2002-2025, with hand searching of pivotal 2026 cohorts) using a predefined string and full eligibility criteria. Factors were classified along three axes of inference and graded into four evidence tiers (replicated; preliminary; susceptibility rather than prognosis; inconsistent). No formal risk-of-bias assessment was undertaken, consistent with the narrative design. RESULTS: The most reproducible post-diagnosis predictors were early inflammatory activity (relapse number and inter-attack interval in the first two years, annualised relapse rate, early EDSS change), lesion topography (brainstem, spinal cord), T2 lesion accrual, serum neurofilament light chain and treatment-related variables (delayed disease-modifying therapy, early high-efficacy treatment). Advanced MRI metrics, serum glial fibrillary acidic protein and other fluid biomarkers remain preliminary; baseline EDSS was inconsistent. Most dietary, environmental and perinatal exposures relate to susceptibility, not course. CONCLUSIONS: Current evidence supports candidate predictors, not a validated instrument, and inference is further complicated by confounding by indication. A multidimensional, externally validated POMS-specific prognostic score remains to be developed-the aim of the ongoing PROMISING study. CI - (c) 2026. The Author(s). FAU - Achille, Mariaclara AU - Achille M AD - Department of Translational Biomedicine and Neurosciences (DiBraiN), University of Bari "Aldo Moro", Bari, Italy. FAU - Copetti, Massimiliano AU - Copetti M AD - Unit of Biostatistics, Fondazione IRCCS "Casa Sollievo Della Sofferenza", San Giovanni Rotondo, Italy. FAU - Guerra, Tommaso AU - Guerra T AD - Department of Translational Biomedicine and Neurosciences (DiBraiN), University of Bari "Aldo Moro", Bari, Italy. FAU - Ferri, Caterina AU - Ferri C AD - Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy. FAU - Iaffaldano, Pietro AU - Iaffaldano P AD - Department of Translational Biomedicine and Neurosciences (DiBraiN), University of Bari "Aldo Moro", Bari, Italy. FAU - D'Alfonso, Sandra AU - D'Alfonso S AD - University of Piemonte Orientale "Amedeo Avogadro", Novara, Italy. FAU - Pugliatti, Maura AU - Pugliatti M AD - Department of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy. FAU - Palumbi, Roberto AU - Palumbi R AD - Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy. FAU - Simone, Marta AU - Simone M AUID- ORCID: 0000-0003-4381-4613 AD - Child Neuropsychiatry Unit, Department of Precision and Regenerative Medicine, Jonic Area, University of Bari "Aldo Moro", Bari, Italy. marta.simone@uniba.it. LA - eng PT - Journal Article PT - Review DEP - 20260729 PL - Germany TA - J Neurol JT - Journal of neurology JID - 0423161 SB - IM MH - Humans MH - *Multiple Sclerosis/diagnosis MH - Prognosis MH - Child MH - *Disease Progression MH - Age of Onset PMC - PMC13421221 OTO - NOTNLM OT - Disability progression OT - Disease-modifying therapy OT - Paediatric-onset multiple sclerosis OT - Prediction models OT - Prognostic factors OT - Serum neurofilament light chain COIS- Declarations. Conflicts of interest: The authors declare no relevant conflicts of interest pertaining to the content of this review. Ethical approval: Not applicable. This article is a narrative review of previously published literature. Consent to participate: Not applicable. Consent for publication: Not applicable. EDAT- 2026/07/29 13:54 MHDA- 2026/07/29 13:55 PMCR- 2026/07/29 CRDT- 2026/07/29 11:12 PHST- 2026/06/18 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/07/17 00:00 [revised] PHST- 2026/07/29 13:55 [medline] PHST- 2026/07/29 13:54 [pubmed] PHST- 2026/07/29 11:12 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.1007/s00415-026-14029-z [pii] AID - 14029 [pii] AID - 10.1007/s00415-026-14029-z [doi] PST - epublish SO - J Neurol. 2026 Jul 29;273(8):495. doi: 10.1007/s00415-026-14029-z. PMID- 42525094 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260923 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 8 DP - 2026 Jul 29 TI - Prospective association between baseline ultra-processed food consumption and future adherence to the 24-h movement guidelines in children: findings from the SENDO project. LID - 10.1007/s00431-026-07287-6 [doi] LID - 621 AB - This study evaluates whether baseline ultra-processed food (UPF) consumption predicts failure to meet 24-h movement guidelines at 2-year follow-up in early childhood. Data from 586 participants (aged 4-5 years at baseline) from the SENDO project were analyzed. Dietary intake was assessed through a validated 149-item FFQ, completed by parents, and categorized by NOVA classification. Physical activity, screen time, and sleep time were assessed through questionnaires, based on the 24-h movement guidelines established by the Canadian Society for Exercise Physiology and the WHO. Overall, 92.0% of participants adhered to at least one guideline, 38.9% met all three, and only 8.0% met none of the recommendations. After adjusting for confounders, children in the highest UPF tertile (T3) had a rate ratio (RR) of 1.27 (95% CI 1.04-1.55; p = 0.021) compared with the lowest (T1). A significant linear trend was observed across UPF tertiles (p for trend = 0.022). Moreover, children in T3 had a greater likelihood of not meeting the recreational screen time guideline (RR 1.82, 95% CI 1.18-2.64; p = 0.036) than those in T1. Absolute screen time was significantly higher in T3 than T1 (1.31 +/- 1.11 vs. 0.94 +/- 1.18 h/day; p < 0.001). CONCLUSION: This study suggests that higher UPF consumption is associated with a lower adherence to 24-h movement recommendations-specifically regarding an increased likelihood of not complying with the recreational screen time recommendation. This highlights the importance of reducing UPF intake to support healthy behaviors over time in early life. WHAT IS KNOWN: * Only a limited number of longitudinal studies have investigated the potential long-term association between dietary habits and the 24-h movement guidelines. * Higher consumption of ultra-processed foods (UPFs) is consistently linked to nutrient imbalances and adverse metabolic outcomes in children and adolescents. WHAT IS NEW: * This is the first study to prospectively investigate the relationship between early-life UPF intake and subsequent nonadherence to the 24-h movement guidelines in preschoolers. * Higher baseline UPF intake predicts a lower likelihood of meeting the movement recommendations after a 2-year follow-up, an association primarily driven by increased sedentary screen time. CI - (c) 2026. The Author(s). FAU - Paladino, Nadia AU - Paladino N AD - Department of Biomedical and Biotechnological Sciences, University of Catania, 95123, Catania, Italy. FAU - Martinez-Gonzalez, Miguel Angel AU - Martinez-Gonzalez MA AD - Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008, Pamplona, Spain. AD - Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Navarra Institute for Health Research, 31008, Pamplona, Spain. AD - Biomedical Research Network Center for Pathophysiology of Obesity and Nutrition (CIBEROBN), Carlos III Health Institute, 28029, Madrid, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Ecuador. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno, Chile. FAU - Grosso, Giuseppe AU - Grosso G AD - Department of Biomedical and Biotechnological Sciences, University of Catania, 95123, Catania, Italy. FAU - Martin-Calvo, Nerea AU - Martin-Calvo N AD - Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, 31008, Pamplona, Spain. nmartincalvo@unav.es. AD - Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Navarra Institute for Health Research, 31008, Pamplona, Spain. nmartincalvo@unav.es. AD - Pathophysiology of Obesity and Nutrition, Centro de Investigacion Biomedica en Red, Instituto de Salud Carlos III, Madrid, Spain. nmartincalvo@unav.es. LA - eng PT - Journal Article DEP - 20260729 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Child, Preschool MH - Male MH - Female MH - Prospective Studies MH - *Fast Foods/statistics & numerical data/adverse effects MH - *Exercise MH - Screen Time MH - Surveys and Questionnaires MH - *Guideline Adherence/statistics & numerical data MH - Sleep Duration MH - Sedentary Behavior MH - Follow-Up Studies PMC - PMC13421281 OTO - NOTNLM OT - Diet OT - Physical activity OT - Preschoolers OT - Screen time OT - Sedentary behavior OT - Sleep duration COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/29 13:54 MHDA- 2026/07/29 13:55 PMCR- 2026/07/29 CRDT- 2026/07/29 11:04 PHST- 2026/01/24 00:00 [received] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/07/21 00:00 [revised] PHST- 2026/07/29 13:55 [medline] PHST- 2026/07/29 13:54 [pubmed] PHST- 2026/07/29 11:04 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.1007/s00431-026-07287-6 [pii] AID - 7287 [pii] AID - 10.1007/s00431-026-07287-6 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jul 29;185(8):621. doi: 10.1007/s00431-026-07287-6. PMID- 42525014 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260918 IS - 1980-5497 (Electronic) IS - 1415-790X (Print) IS - 1415-790X (Linking) VI - 29 DP - 2026 TI - Risk and Protective Factor Indicators Management Committee: methodological approach in the construction of indicators of the interagency health information network (Ripsa), 2023. PG - e260026 LID - S1415-790X2026000101025 [pii] LID - 10.1590/1980-549720260026 [doi] LID - e260026 AB - OBJECTIVE: To describe the role of the Risk and Protective Factors Indicator Management Committee (RPF CGI) in the resumption and update of the Interagency Health Information Network (Rede Interagencial de Informacoes para a Saude - Ripsa) indicator matrix in 2023, highlighting the sustainability of data sources and validation processes. METHODS AND RESULTS: Interinstitutional technical meetings were held between 2023 and 2025, involving 36 institutions, to review, define, and validate the indicators using a standardized indicator qualification form. A consensus was reached to use data from the Surveillance System for Risk and Protective Factors for Chronic Diseases by Telephone Survey (Sistema de Vigilancia de Fatores de Risco e Protecao para Doencas Cronicas por Inquerito Telefonico - Vigitel), National Study of Infant Feeding and Nutrition (Estudo Nacional de Alimentacao e Nutricao Infantil - Enani), Live Birth Information System (Sistema de Informacoes sobre Nascidos Vivos - Sinasc), National Health Survey (Pesquisa Nacional de Saude - PNS), Household Budget Survey (Pesquisa de Orcamentos Familiares - POF), National School Health Survey (Pesquisa Nacional de Saude do Escolar - PeNSE), National Demographic and Health Survey (Pesquisa Nacional de Demografia e Saude - PNDS), Annual Industrial Survey - Product (Pesquisa Industrial Anual - Produto - PIA-Produto), National Survey on Health and Nutrition (Pesquisa Nacional sobre Saude e Nutricao - PNSN), and National Oral Health Survey (Pesquisa Nacional de Saude Bucal - SB Brasil). The matrix was expanded to 39 indicators, distributed across nine dimensions: noncommunicable chronic diseases, alcohol consumption, smoking, physical activity, nutritional status, dietary intake, childbirth, violence, and oral health. CONCLUSION: The RPF CGI contributed to the qualification and sustainability of Ripsa indicators, which are essential for monitoring public policies, supporting evidence-based decision-making, and addressing health inequalities, aligning with national and international agendas such as the Sustainable Development Goals. FAU - Malta, Deborah Carvalho AU - Malta DC AUID- ORCID: 0000-0002-8214-5734 AD - Universidade Federal de Minas Gerais, School of Nursing, Department of Maternal-Child Nursing and Public Health - Belo Horizonte (MG), Brazil. FAU - Oliveira, Max Moura de AU - Oliveira MM AUID- ORCID: 0000-0002-0804-5145 AD - Universidade Federal de Goias, Instituto de Patologia Tropical e Saude Publica, Department of Collective Health - Goias (GO), Brazil. FAU - Freitas, Mariana Goncalves de AU - Freitas MG AUID- ORCID: 0000-0002-6679-032X AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Antunes, Anna Beatriz Souza AU - Antunes ABS AUID- ORCID: 0000-0001-7813-5421 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Ricardo, Leticia Mendes AU - Ricardo LM AUID- ORCID: 0009-0005-7137-2375 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Tierling, Vera Lucia AU - Tierling VL AUID- ORCID: 0000-0001-9856-2017 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Santos, Debora Franca Dos AU - Santos DFD AUID- ORCID: 0000-0003-3917-2291 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Freitas, Paula Carvalho de AU - Freitas PC AUID- ORCID: 0000-0002-3737-2962 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Oliveira Baldi, Flora Vitoria Serena AU - Oliveira Baldi FVS AUID- ORCID: 0009-0006-7619-1415 AD - Universidade Federal de Minas Gerais, School of Nursing - Belo Horizonte (MG), Brazil. FAU - Carrato, Barbara Aguiar AU - Carrato BA AUID- ORCID: 0000-0001-8102-5741 AD - Universidade Federal de Minas Gerais, School of Nursing - Belo Horizonte (MG), Brazil. FAU - Ferreira, Ana Lorena Lima AU - Ferreira ALL AUID- ORCID: 0000-0003-4236-2651 AD - Ministry of Health, Secretariat of Primary Health Care - Brasilia (DF), Brazil. FAU - Santos, Thanise Sabrina Souza AU - Santos TSS AUID- ORCID: 0000-0003-4087-1815 AD - Ministry of Health, Secretariat of Primary Health Care - Brasilia (DF), Brazil. FAU - Oliveira, Gabriela AU - Oliveira G AUID- ORCID: 0000-0002-2403-5094 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Silva, Isabela da Costa Gaspar da AU - Silva IDCGD AUID- ORCID: 0000-0001-7329-3527 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Menezes-Junior, Luiz Antonio Alves de AU - Menezes-Junior LAA AUID- ORCID: 0000-0002-4497-5358 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Moraes, Luci Fabiane Scheffer AU - Moraes LFS AUID- ORCID: 0000-0003-1034-3878 AD - Ministry of Health, Secretariat of Information and Digital Health - Brasilia (DF), Brazil. CN - Management Committee on Risk and Protective Factors Indicators FAU - Gomes, Gabriella Farias AU - Gomes GF AUID- ORCID: 0000-0001-9118-9694 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Gomes, Julia do Amaral AU - Gomes JA AUID- ORCID: 0000-0001-0002-0003 AD - Ministry of Health, Secretariat of Health Surveillance and Environment - Brasilia (DF), Brazil. FAU - Konstantyner, Tulio AU - Konstantyner T AUID- ORCID: 0000-0002-7931-9692 AD - Universidade Federal de Sao Paulo - Sao Paulo (SP), Brazil. FAU - Boing, Alexandra Crispim AU - Boing AC AUID- ORCID: 0000-0001-7792-4824 AD - Universidade Federal de Santa Catarina - Florianopolis (SC), Brazil. FAU - Lara, Joao Victor Ingles de AU - Lara JVI AUID- ORCID: 0000-0001-7079-246X AD - Ministry of Health, Secretariat of Primary Health Care, General Coordination of Oral Health - Brasilia (DF), Brazil FAU - Alves, Luciana Correia AU - Alves LC AUID- ORCID: 0000-0002-8598-4875 AD - Associacao Brasileira de Estudos Populacionais - Campinas (SP), Brazil. FAU - Silva, Josy Maria de Pinho da AU - Silva JMP AUID- ORCID: 0000-0002-7187-1028 AD - World Health Organization, Pan American Health Organization - Brasilia (DF), Brazil. FAU - Szklo, Andre Salem AU - Szklo AS AUID- ORCID: 0000-0003-1903-6188 AD - Instituto Nacional de Cancer - Rio de Janeiro (RJ), Brazil. FAU - Pavao, Ana Luiza Braz AU - Pavao ALB AUID- ORCID: 0000-0002-4122-1796 AD - Fundacao Oswaldo Cruz, Instituto de Comunicacao e Informacao Cientifica e Tecnologica em Saude - Rio de Janeiro (RJ), Brazil. FAU - Fernandes, Hugo AU - Fernandes H AUID- ORCID: 0000-0003-2380-2914 AD - Universidade Federal de Sao Paulo - Sao Paulo (SP), Brazil. FAU - Araujo, Marina Campos AU - Araujo MC AUID- ORCID: 0000-0002-7980-6618 AD - Fundacao Oswaldo Cruz, Instituto de Comunicacao e Informacao Cientifica e Tecnologica em Saude - Rio de Janeiro (RJ), Brazil. FAU - Falcao, Kandice de Melo AU - Falcao KM AUID- ORCID: 0000-0002-6725-6110 AD - Conselho Nacional de Secretarias Municipais de Saude - Brasilia (DF), Brazil. FAU - Marque, Emanuele Souza AU - Marque ES AUID- ORCID: 0000-0002-8633-7290 AD - Universidade do Estado do Rio de Janeiro, Instituto de Medicina Social Hesio Cordeiro - Rio de Janeiro (RJ), Brazil. FAU - Levy, Renata Bertazzi AU - Levy RB AUID- ORCID: 0000-0001-5388-7002 AD - Universidade de Sao Paulo, Faculdade de Medicina - Sao Paulo (SP), Brazil. FAU - Carneiro, Joana Danielle Brandao AU - Carneiro JDB AUID- ORCID: 0000-0003-3629-8091 AD - Ministry of Health, Secretariat of Primary Health Care, Secretariat of Primary Health Care - Brasilia (DF), Brazil. FAU - Carvasan, Gislaine Aparecida Fonsechi AU - Carvasan GAF AUID- ORCID: 0000-0002-1668-9856 AD - Universidade Estadual de Campinas - Campinas (SP), Brazil. FAU - Sampaio, Aline Fernanda Silva AU - Sampaio AFS AUID- ORCID: 0000-0002-9805-2946 AD - Universidade Federal do Acre - Rio Branco (AC), Brazil. FAU - Nunes, Monica da Silva AU - Nunes MS AUID- ORCID: 0000-0002-5078-9121 AD - Universidade Federal de Sao Carlos - Sao Carlos (SP), Brazil. FAU - Boni, Raquel Brandini De AU - Boni RB AUID- ORCID: 0000-0002-2455-5997 AD - Fundacao Oswaldo Cruz, Instituto de Comunicacao e Informacao Cientifica e Tecnologica em Saude - Rio de Janeiro (RJ), Brazil. FAU - Gomes, Crizian Saar AU - Gomes CS AUID- ORCID: 0000-0001-6586-4561 AD - Universidade Federal de Minas Gerais - Belo Horizonte (MG), Brazil. FAU - Boing, Antonio Fernando AU - Boing AF AUID- ORCID: 0000-0001-9331-1550 AD - Universidade Federal de Santa Catarina - Florianopolis (SC), Brazil FAU - Sousa, Juliana Lourenco AU - Sousa JL AUID- ORCID: 0009-0000-4220-128X AD - World Health Organization, Pan American Health Organization, Centro Latino-Americano e do Caribe de Informacao em Ciencias da Saude - Sao Paulo (SP), Brazil. FAU - Gomes, Marilia Miranda Forte AU - Gomes MMF AUID- ORCID: 0000-0001-8584-9676 AD - Associacao Brasileira de Estudos Populacionais - Campinas (SP), Brazil. FAU - Mello, Marcia Sarpa de Campos AU - Mello MSC AUID- ORCID: 0000-0001-8976-4653 AD - Instituto Nacional de Cancer - Rio de Janeiro (RJ), Brazil. FAU - Andrade, Joanlise Marco de Leon AU - Andrade JML AUID- ORCID: 0000-0002-3984-3799 AD - Universidade de Brasilia - Brasilia (DF), Brazil. FAU - Bousquet-Santos, Kelb AU - Bousquet-Santos K AUID- ORCID: 0000-0002-4687-4681 AD - Universidade de Brasilia - Brasilia (DF), Brazil. FAU - Lima, Everton Emanuel Campos de AU - Lima EEC AUID- ORCID: 0000-0001-6275-9854 AD - Universidade Estadual de Campinas - Campinas (SP), Brazil. FAU - Henrique, Rafael dos Santos AU - Henrique RS AUID- ORCID: 0000-0003-3912-5559 AD - Universidade Federal de Pernambuco - Recife (PE), Brazil. LA - eng LA - por PT - Journal Article DEP - 20260727 PL - Brazil TA - Rev Bras Epidemiol JT - Revista brasileira de epidemiologia = Brazilian journal of epidemiology JID - 100954576 SB - IM MH - Humans MH - Brazil MH - Risk Factors MH - *Health Status Indicators MH - *Health Information Systems/organization & administration PMC - PMC13405555 COIS- CONFLICT OF INTERESTS: nothing to declare EDAT- 2026/07/29 13:54 MHDA- 2026/07/29 13:55 PMCR- 2026/07/27 CRDT- 2026/07/29 11:03 PHST- 2025/12/10 00:00 [received] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/07/29 13:55 [medline] PHST- 2026/07/29 13:54 [pubmed] PHST- 2026/07/29 11:03 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - S1415-790X2026000101025 [pii] AID - 10.1590/1980-549720260026 [doi] PST - epublish SO - Rev Bras Epidemiol. 2026 Jul 27;29:e260026. doi: 10.1590/1980-549720260026. eCollection 2026. PMID- 42524610 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 0912-0009 (Print) IS - 1880-5086 (Electronic) IS - 0912-0009 (Linking) VI - 79 IP - 1 DP - 2026 Jul 1 TI - Trace elements in relation to glycemic control and disease complications in children living with type 1 diabetes mellitus. PG - 86-96 LID - 10.3164/jcbn.26-3 [doi] AB - Trace elements such as copper, zinc, and magnesium are essential for antioxidant defense, insulin action and glucose homeostasis, yet their clinical utility as biomarkers in childhood type 1 diabetes mellitus remains uncertain. We conducted a case-control study of 199 Egyptian children aged 5-18 years (100 with type 1 diabetes mellitus and 99 non-diabetic controls) attending the National Nutrition Center. Anthropometry, lifestyle characteristics and biochemistry were assessed, and serum copper, zinc, and magnesium were measured by atomic absorption; the copper to zinc ratio was calculated. Children with type 1 diabetes mellitus had significantly lower zinc and magnesium concentrations and higher copper to zinc ratios than controls, while mean copper levels did not differ significantly. Lower magnesium and zinc, higher body mass index, elevated triglycerides, and reduced physical activity were independently associated with type 1 diabetes mellitus. In receiver operating characteristic analyses, magnesium showed the best discriminative performance between diabetic and control children, whereas zinc and the copper to zinc ratio were highly specific markers of poor glycemic control, and zinc deficiency and reduced estimated glomerular filtration rate were consistently associated with microvascular complications. These findings support trace-element monitoring to refine risk stratification and management in pediatric type 1 diabetes mellitus. CI - Copyright (c) 2026 JCBN. FAU - Ibrahim, Randa AU - Ibrahim R AD - Clinical and Chemical Pathology Department, National Nutrition Institute, The General Organization for Teaching Hospitals and Institutes (GOTHI), Cairo, Egypt. FAU - Mohamed, Amal Ahmed AU - Mohamed AA AD - Biochemistry and Molecular Biology Department, National Hepatology and Tropical Medicine Research Institute, The General Organization for Teaching Hospitals and Institutes (GOTHI), Cairo, Egypt. FAU - Abbas, Enas Sayed AU - Abbas ES AD - Pediatric Clinical Nutrition Department, National Nutrition Institute, The General Organization for Teaching Hospitals and Institutes (GOTHI), Egypt. FAU - Sultan, Eman AU - Sultan E AD - Department of Endocrinology, National Nutrition Institute, The General Organization for Teaching Hospitals and Institutes (GOTHI), Cairo, Egypt. FAU - Selim, May Mohsen Samy AU - Selim MMS AD - Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Samy, Lamees Ahmed AU - Samy LA AD - Clinical and Chemical Pathology Department, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Fahmy, Eman M AU - Fahmy EM AD - Endocrinology & Metabolism, Internal Medicine Department, Faculty of Medicine, Capital University, Cairo, Egypt. FAU - Saad, Mohamed AbdelFattah Ibrahim AU - Saad MAI AD - Pediatric Department, Almataria Teaching Hospital, The General Organization for Teaching Hospitals and Institutes (GOTHI), Cairo, Egypt. FAU - Anwer, Omnia M AU - Anwer OM AD - Public Health and Community Medicine Department, Faculty of Medicine, Benha University, Benha, Qalyubiyah Governorate, Egypt. FAU - Girgiss, Mina Wassef AU - Girgiss MW AD - Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt. FAU - El Sherbiny, Mohamed AU - El Sherbiny M AD - Internal Medicine Department, Faculty of Medicine, Cairo University, Cairo, Egypt. FAU - Batota, Yasser AU - Batota Y AD - NMC Royal Hospital, Khalifa City, Abu Dhabi, United Arab Emirates. FAU - Mohammad, Rahmathullah AU - Mohammad R AD - NMC Royal Hospital, Khalifa City, Abu Dhabi, United Arab Emirates. FAU - Hafez, Wael AU - Hafez W AD - Medical Research and Clinical Studies Institute, National Research Centre, Cairo, Egypt. AD - NMC Royal Hospital, Khalifa City, Abu Dhabi, United Arab Emirates. AD - College of Medicine and Health Science, Khalifa University, Abu Dhabi, United Arab Emirates. AD - The Emirates Society of Internal Medicine (ESIM), Emirates Medical Association, 46th Street Deira Near International Bowling Centre, Dubai, United Arab Emirates. LA - eng PT - Journal Article DEP - 20260428 PL - Japan TA - J Clin Biochem Nutr JT - Journal of clinical biochemistry and nutrition JID - 8700907 PMC - PMC13412591 OTO - NOTNLM OT - copper to zinc ratio OT - magnesium OT - trace elements OT - type 1 diabetes mellitus OT - zinc COIS- No potential conflicts of interest were disclosed. EDAT- 2026/07/29 13:54 MHDA- 2026/07/29 13:55 PMCR- 2026/04/28 CRDT- 2026/07/29 10:40 PHST- 2026/01/05 00:00 [received] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/07/29 13:55 [medline] PHST- 2026/07/29 13:54 [pubmed] PHST- 2026/07/29 10:40 [entrez] PHST- 2026/04/28 00:00 [pmc-release] AID - DN/JST.JSTAGE/jcbn/26-3 [pii] AID - 10.3164/jcbn.26-3 [doi] PST - ppublish SO - J Clin Biochem Nutr. 2026 Jul 1;79(1):86-96. doi: 10.3164/jcbn.26-3. Epub 2026 Apr 28. PMID- 42524307 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2197-1153 (Print) IS - 2197-1153 (Electronic) IS - 2197-1153 (Linking) VI - 13 IP - 3 DP - 2026 Jul TI - Postoperative computed tomography-derived bundle morphology ratios are associated with noncontact graft failure after double-bundle anterior cruciate ligament reconstruction in adolescents. PG - e70864 LID - 10.1002/jeo2.70864 [doi] LID - e70864 AB - PURPOSE: To evaluate whether postoperative computed tomography (CT)-derived bundle-specific morphology ratios are associated with noncontact graft failure following anatomic double-bundle anterior cruciate ligament (ACL) reconstruction in adolescents. METHODS: This single-centre retrospective cohort study included 133 consecutive patients aged 15-19 years who underwent primary anatomic double-bundle ACL reconstruction with routine postoperative CT at 1 week postoperatively and a minimum follow-up of 24 months; all patients had a complete 2-year outcome assessment. Patients with a lateral femoral condyle ratio (LFCR) >/= 62.18% were excluded, as this threshold has been associated with substantially elevated graft rerupture risk [2]. Only noncontact graft failures within 2 years were considered events. Preoperative MRI was used to assess femoral morphology, and postoperative CT was used to quantify anteromedial (AMR) and posterolateral (PLR) bundle morphology ratios. Receiver operating characteristic analysis and multivariable logistic regression were performed to evaluate discriminative ability and independent associations with graft failure. RESULTS: Both AMR and PLR were significantly associated with graft failure and demonstrated moderate-to-good discriminative ability (area under the curve 0.804 and 0.799, respectively). In multivariable analysis adjusting for age, sex, BMI, activity level and meniscal injury status, only AMR remained associated with graft failure in an exploratory multivariable model (OR: 1.15 per 0.01-unit increase, 95% CI: 1.02-1.31; p = 0.026). Intraobserver reliability was good to excellent across all parameters (intraclass correlation coefficients 0.878-0.949). CONCLUSION: Postoperative CT-derived bundle morphology ratios are associated with noncontact graft failure following anatomic double-bundle ACL reconstruction, with AMR bundle morphology demonstrating the strongest association in an exploratory multivariable model. These preliminary findings suggest that quantitative morphology ratios may be useful for future risk stratification, but prospective validation is required before clinical implementation. LEVEL OF EVIDENCE: Level III, retrospective cohort study. CI - (c) 2026 The Author(s). Journal of Experimental Orthopaedics published by John Wiley & Sons Ltd on behalf of European Society of Sports Traumatology, Knee Surgery and Arthroscopy. FAU - Takeuchi, Yuko AU - Takeuchi Y AUID- ORCID: 0009-0005-7009-5628 AD - Department of Orthopedic Surgery Asahi University Hospital Gifu Japan. FAU - Kawai, Ryosuke AU - Kawai R AD - Department of Orthopedic Surgery Asahi University Hospital Gifu Japan. FAU - Hiraiwa, Hideki AU - Hiraiwa H AD - Department of Orthopedic Surgery Asahi University Hospital Gifu Japan. FAU - Tsukahara, Takashi AU - Tsukahara T AD - Department of Orthopedic Surgery Asahi University Hospital Gifu Japan. LA - eng PT - Journal Article DEP - 20260728 PL - United States TA - J Exp Orthop JT - Journal of experimental orthopaedics JID - 101653750 PMC - PMC13410946 OTO - NOTNLM OT - anterior cruciate ligament OT - double-bundle reconstruction OT - graft failure OT - imaging morphology OT - risk prediction COIS- The authors declare no conflict of interest. EDAT- 2026/07/29 13:54 MHDA- 2026/07/29 13:55 PMCR- 2026/07/28 CRDT- 2026/07/29 10:31 PHST- 2026/04/09 00:00 [received] PHST- 2026/07/08 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/07/29 13:55 [medline] PHST- 2026/07/29 13:54 [pubmed] PHST- 2026/07/29 10:31 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - JEO270864 [pii] AID - 10.1002/jeo2.70864 [doi] PST - epublish SO - J Exp Orthop. 2026 Jul 28;13(3):e70864. doi: 10.1002/jeo2.70864. eCollection 2026 Jul. PMID- 42524052 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 0974-7052 (Print) IS - 0975-1904 (Electronic) IS - 0974-7052 (Linking) VI - 19 IP - 6 DP - 2026 Jun TI - Evaluation of Screen Time, Oral Health Status, and Sleep Disturbances in Children between 6 and 13 years: A Cross-sectional Study. PG - 711-717 LID - 10.5005/jp-journals-10005-3538 [doi] AB - BACKGROUND: Sleep is a critical component required for the growth and development of a child. Deviation from the normal sleep pattern, quality, and quantity directly affects the baseline functioning of the individual. Increased screen time exposure affects the overall well-being of the child, particularly the sleep and oral health. AIM: To assess the average screen time exposure, oral health status, and prevalence of sleep disorders in children between 6 and 13 years of age. MATERIALS AND METHODS: This cross-sectional study included 370 children visiting the Department of Pediatric and Preventive Dentistry between July 2024 and January 2025. Data were collected using a validated screen time questionnaire and the Sleep Disturbance Scale for Children. Dental caries was assessed using the ICDAS II index. The descriptive statistics were reported in the form of mean and standard deviation. ANOVA, bivariate, and multivariate linear regression analyses were performed. Statistical significance was noted when the p-value was 0.90), including parent-reported toe-walking percentage, satisfaction, treatment adherence, pain-on-activity, and clinician-reported gait scale. Validity analyses showed significant and meaningful correlations between iTWO proforma-T items and established measures. The estimated toe-walking percentage correlated strongly with the Toe Walking Severity Scale (rho = -0.549) and the OxAFQ emotional domain (rho = -0.493). Functional performance items (gait scale, 2- and 6-minute walk tests) showed moderate positive correlations with toe-walking severity, whereas pain-related items correlated negatively with relevant PODCI and OxAFQ domains. CONCLUSION: The iTWO proforma-T is a valid and reliable instrument for evaluating symptoms, functional status, and treatment-related outcomes in children with idiopathic toe walking. The tool preserves the structure and measurement characteristics of the original proforma and can be confidently used by clinicians and researchers for evidence-based assessment and follow-up in Turkish-speaking pediatric populations. CI - (c) 2026 The Author(s). Journal of Foot and Ankle Research published by John Wiley & Sons Australia, Ltd on behalf of Australian Podiatry Association and The Royal College of Podiatry. FAU - Giray, Esra AU - Giray E AUID- ORCID: 0000-0003-3895-4486 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Karadag, Munteha Ilkyaz AU - Karadag MI AUID- ORCID: 0009-0001-6500-3072 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Sisli Hamidiye Etfal Training and Research Hospital, Istanbul, Turkiye. FAU - Turkyilmaz, Sude Gozukucuk AU - Turkyilmaz SG AUID- ORCID: 0009-0008-2381-4089 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Celik, Kubra Yildiz AU - Celik KY AUID- ORCID: 0009-0002-1920-5682 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Akpinar, Pinar AU - Akpinar P AUID- ORCID: 0000-0002-7796-0750 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Illeez, Ozge Gulsum AU - Illeez OG AUID- ORCID: 0000-0002-3824-4428 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Unlu Ozkan, Feyza AU - Unlu Ozkan F AUID- ORCID: 0000-0002-7686-1347 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Aktas, Ilknur AU - Aktas I AUID- ORCID: 0000-0002-1050-9666 AD - Department of Physical Medicine and Rehabilitation, University of Health Sciences Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkiye. FAU - Karadag-Saygi, Evrim AU - Karadag-Saygi E AUID- ORCID: 0000-0002-7420-9902 AD - Department of Physical Medicine and Rehabilitation, Marmara University School of Medicine, Istanbul, Turkiye. FAU - Williams, Cylie M AU - Williams CM AUID- ORCID: 0000-0002-0223-9141 AD - School of Primary and Allied Health Care, Monash University, Peninsula Campus, Frankston, Victoria, Australia. LA - eng PT - Journal Article PT - Validation Study PL - United States TA - J Foot Ankle Res JT - Journal of foot and ankle research JID - 101471610 SB - IM MH - Humans MH - Child MH - Reproducibility of Results MH - Female MH - Child, Preschool MH - Male MH - Adolescent MH - *Toes/physiopathology MH - Turkey MH - *Walking/physiology MH - Surveys and Questionnaires MH - Severity of Illness Index MH - Psychometrics MH - *Movement Disorders/physiopathology/diagnosis MH - Treatment Outcome PMC - PMC13415977 OTO - NOTNLM OT - 6-minute walk test OT - Toe Walking Severity Scale OT - idiopathic toe walking OT - treatment outcomes OT - weight-bearing lunge COIS- The authors declare no conflicts of interest. EDAT- 2026/07/29 06:35 MHDA- 2026/07/29 18:39 PMCR- 2026/07/28 CRDT- 2026/07/29 01:43 PHST- 2026/07/07 00:00 [revised] PHST- 2026/02/16 00:00 [received] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/29 18:39 [medline] PHST- 2026/07/29 06:35 [pubmed] PHST- 2026/07/29 01:43 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - JFA270188 [pii] AID - 10.1002/jfa2.70188 [doi] PST - ppublish SO - J Foot Ankle Res. 2026 Sep;19(3):e70188. doi: 10.1002/jfa2.70188. PMID- 42522101 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260912 IS - 1365-2036 (Electronic) IS - 0269-2813 (Print) IS - 0269-2813 (Linking) VI - 64 IP - 7 DP - 2026 Oct TI - Review Article: Accelerating Coeliac Disease Clinical Trials-Beyond Celiac Meeting With Industry, Academics, Patients and the FDA. PG - 890-896 LID - 10.1111/apt.70873 [doi] AB - BACKGROUND: Coeliac disease is due to an acquired, lifelong gluten-specific immune response resulting in a gluten-dependent chronic immune-mediated enteropathy associated with gastrointestinal and extraintestinal morbidity. Strictly avoiding dietary gluten is the only available management but has never been subjected to rigorous efficacy assessment now required for a pharmaceutical agent. Gluten-free diet (GFD) is partially and inconsistently effective, but it places a high burden on patients, families, the food industry, and regulators and is defined inconsistently around the world, highlighting the need for effective and convenient adjunctive pharmacological therapies. AIMS: To summarize key patient, scientific, and regulatory considerations for coeliac disease drug development based on a multi-stakeholder meeting focused on accelerating clinical trials. METHODS: A pre-competitive meeting convened by the Beyond Celiac Coalition (May 2024) included patients with coeliac disease, academic experts, pharmaceutical industry representatives, and participants from the US Food and Drug Administration. Moderated panel addressed patient priorities, symptom and histologic endpoints, biopsy and histology methods, gluten challenge design, clinical trial duration, and regulatory expectations. Themes were synthesized qualitatively with focus on trial design implications and unresolved questions. RESULTS: Participants described high symptom burden and psychosocial impact despite gluten-free diet adherence underscoring unmet therapeutic need in coeliac disease. Regulatory perspectives emphasized the need for clinically meaningful improvement and evidence of intestinal benefit, framed as symptom and histology co-primary endpoints in clinical trials. These expectations were discussed as most applicable to trial populations with both clinically meaningful symptoms and active histologic injury at baseline; for other phenotypes, it was emphasized that endpoint strategy, the role of gluten exposure, and trial duration should be tailored case by case to the population and mechanism of action. Practical challenges identified included endpoint selection and definition, discordance between symptoms and histology, selecting fit-for-purpose symptom measures; standardizing biopsy acquisition and central histology reads to address patchiness and variability, pre-specifying definitions of meaningful histologic change given ongoing uncertainty about healing, and trial feasibility. Controlled gluten exposure was discussed as a tool to improve interpretability of efficacy outcomes, with careful consideration of dose, duration, patient burden and safety. Discussion addressed the ideal length of the double-blind period, including a shorter 24-week double-blind study with an open-label extension versus a 52-week double-blind design. Trial duration should balance scientific rigour, patient retention, and the need for longer-term safety and durability data, with flexibility to tailor the approach to context. CONCLUSIONS: Progress in coeliac disease drug development will require patient-centred, scientifically robust but feasible trial designs with appropriate endpoints, justified use of gluten exposure, consideration of improved biomarkers to reduce patient burden and early regulatory engagement. Continued multi-stakeholder collaboration, including dedicated consideration of paediatric drug development, is essential to advance effective therapies. CI - (c) 2026 The Author(s). Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd. FAU - Fahey, Lisa M AU - Fahey LM AUID- ORCID: 0009-0009-5823-425X AD - Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. AD - University of Pennsylvania, Philadelphia, Pennsylvania, USA. FAU - Anderson, Robert AU - Anderson R AD - International Society for the Study of Celiac Disease, Groningen, the Netherlands. AD - Mackay Base Hospital, Mackay, Queensland, Australia. FAU - Liu, Edwin AU - Liu E AD - Children's Hospital Colorado, University of Colorado School of Medicine, Aurora, Colorado, USA. FAU - Murray, Joseph A AU - Murray JA AUID- ORCID: 0000-0003-1941-9090 AD - Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA. FAU - Robert, Marie E AU - Robert ME AUID- ORCID: 0000-0002-6385-4578 AD - Yale University School of Medicine, New Haven, Connecticut, USA. FAU - Silvester, Jocelyn Anne AU - Silvester JA AUID- ORCID: 0000-0002-3615-1666 AD - Boston Children's Hospital, Boston, Massachusetts, USA. AD - Harvard Medical School, Boston, Massachusetts, USA. FAU - Avery, Kate AU - Avery K AD - Beyond Celiac, Ambler, Pennsylvania, USA. FAU - Cheinquer, Nelson AU - Cheinquer N AD - Takeda, Cambridge, Massachusetts, USA. FAU - Grebe, Kristie AU - Grebe K AD - Anokion, Cambridge, Massachusetts, USA. AD - Navigator Medicines, Cambridge, Massachusetts, USA. FAU - Tulabandula, Bhargav AU - Tulabandula B AD - Takeda, Cambridge, Massachusetts, USA. FAU - Leffler, Daniel A AU - Leffler DA AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Chugai Pharmaceuticals, Berkeley Height, New Jersey, USA. CN - Beyond Celiac Coalition LA - eng PT - Journal Article PT - Review DEP - 20260728 PL - England TA - Aliment Pharmacol Ther JT - Alimentary pharmacology & therapeutics JID - 8707234 SB - IM MH - *Celiac Disease/diet therapy/drug therapy MH - Humans MH - *Diet, Gluten-Free MH - United States MH - *Clinical Trials as Topic MH - United States Food and Drug Administration MH - *Drug Development PMC - PMC13559503 OTO - NOTNLM OT - Beyond Celiac Coalition OT - Food and Drug Administration OT - coeliac disease OT - drug development COIS- Lisa M. Fahey: None. Robert Anderson: Shareholder and Director, Novoviah Pharmaceuticals Pty. Ltd., Brisbane Queensland Australia. No grants; Shareholder and Director, JM Clinical Pty Ltd, Brisbane, Queensland Australia. No grants; Consultant to: Topas Therapeutics GmbH, Hamburg, Germany; Takeda Pharmaceutical Company Ltd/Millennium Pharmaceuticals, Cambridge MA USA; Forte Bioscience Inc., Dallas TX, USA; Barinthus Biotherapeutics, Germantown, MD, USA; Immunic AG, Grafelfing, Germany; Universal Cells-ASTELLAS LLC US, Seattle, WA, USA; AMYRA Biotech AG, Basel, Switzerland; DBV, Paris, France; EVOQ Therapeutics, Ann Arbor, MI, USA; Kanyos Bio Inc., Cambridge, MA, USA; Kerna Ventures; Catalys Pacific; Georgiamune Inc.; Sonoma Biotherapeutics Inc., South San Francisco, CA, USA; Switchback Therapeutics Inc.; TregTherapeutics Inc., NC, USA. Edwin Liu: Takeda consultant, UpToDate contributor. Joseph A. Murray: None. Marie E. Robert: Consultant for Takeda, Anokion, Alimentiv, Teva, BMS. Salary support from AstraZeneca. Jocelyn Anne Silvester: Consulting (last 5 years): Alimentiv, Chugai Pharmaceuticals, GLG, Guidepoint, Lumanity, Takeda Pharmaceuticals, Teva Pharmaceuticals. Research Grants to Institution (last 5 years): Amgen, Glutenostics LLC, Janssen, Milky Way Life Sciences, Takeda Pharmaceuticals. Foundation Grants (last 5 years): Allan Foundation, American College of Gastroenterology, Beyond Celiac, Celiac Disease Foundation, Chan Zuckerburg Initiative, Global Autoimmune Institute, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition. Kate Avery: Consultant to Chugai Pharmaceuticals. Nelson Cheinquer: Employee of Takeda Development Center Americas and is a stockholder in Takeda Pharmaceutical Company Limited. Kristie Grebe: At time of the meeting, was an Anokion employee and shareholder, currently Navigator Medicines employee and shareholder. Bhargav Tulabandula: Employee of Takeda Development Center Americas and is a stockholder in Takeda Pharmaceutical Company Limited. Daniel A. Leffler: Employee of Chugai Pharma; Board Member of Foundation for Celiac Disease Outcome Measures. Potential conflicts of interest are outlined above in the disclosure section. EDAT- 2026/07/29 06:35 MHDA- 2026/09/10 11:54 PMCR- 2026/09/10 CRDT- 2026/07/29 00:23 PHST- 2026/07/13 00:00 [revised] PHST- 2025/09/05 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/09/10 11:54 [medline] PHST- 2026/07/29 06:35 [pubmed] PHST- 2026/07/29 00:23 [entrez] PHST- 2026/09/10 00:00 [pmc-release] AID - APT70873 [pii] AID - 10.1111/apt.70873 [doi] PST - ppublish SO - Aliment Pharmacol Ther. 2026 Oct;64(7):890-896. doi: 10.1111/apt.70873. Epub 2026 Jul 28. PMID- 42521910 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260819 IS - 1539-0829 (Electronic) IS - 1534-4827 (Print) IS - 1534-4827 (Linking) VI - 26 IP - 1 DP - 2026 Jul 29 TI - Insulin-Related Disordered Eating Behaviour: A Scoping Review of Evidence. LID - 10.1007/s11892-026-01637-2 [doi] LID - 23 AB - PURPOSE OF REVIEW: Current understanding of insulin-related disordered eating behaviour is limited by inconsistencies in terminology and measurement. Prevalence of the behaviour and characteristics of individuals are unclear. How best to intervene and with whom is therefore unknown. This scoping review summarises existing knowledge as a first step to addressing the problem. Eligible sources investigated individuals with T1D restricting or inflating insulin with disordered eating motivations. Charted data included study aims, sample characteristics, measures, and key findings. RECENT FINDINGS: Samples converged on adolescent females in USA, Canada and western Europe. Numerous measures were used, few had received extensive validation. Prevalence estimates, and models of development and maintenance were inconsistent. The validity and generalisability of measures should be improved, particularly so that diverse perspectives (e.g., males, non-Western cultures), so far overlooked, are captured. Identity and social relationships appeared particularly important in the development and maintenance of insulin-related disordered eating behaviour and recovery, and could be a potential target for interventions. CI - (c) 2026. The Author(s). FAU - Shelford, Amy AU - Shelford A AUID- ORCID: 0000-0002-2666-1144 AD - School of Psychology and Clinical Language Sciences, University of Reading, Whiteknights Campus, RG6 6ES, Reading, England. a.shelford@pgr.reading.ac.uk. FAU - Jenkins, Paul E AU - Jenkins PE AUID- ORCID: 0000-0003-1673-2903 AD - School of Psychology and Clinical Language Sciences, University of Reading, Whiteknights Campus, RG6 6ES, Reading, England. FAU - Harvey, Kate AU - Harvey K AUID- ORCID: 0000-0002-6819-0934 AD - School of Psychology and Clinical Language Sciences, University of Reading, Whiteknights Campus, RG6 6ES, Reading, England. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260729 PL - United States TA - Curr Diab Rep JT - Current diabetes reports JID - 101093791 RN - 0 (Insulin) SB - IM MH - Humans MH - *Feeding and Eating Disorders/epidemiology/chemically induced/psychology MH - *Insulin/adverse effects/administration & dosage MH - Female MH - *Diabetes Mellitus, Type 1/drug therapy/psychology MH - *Feeding Behavior/psychology PMC - PMC13415336 OTO - NOTNLM OT - Type 1 diabetes OT - insulin inflation OT - insulin restriction OT - insulin-related disordered eating behaviour COIS- Declarations. Human or Animal Rights: This article does not contain any studies with human or animal subjects performed by any of the authors. Competing interests: The authors declare no competing interests. EDAT- 2026/07/29 00:35 MHDA- 2026/07/29 18:39 PMCR- 2026/07/29 CRDT- 2026/07/28 23:23 PHST- 2025/09/17 00:00 [received] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/07/29 18:39 [medline] PHST- 2026/07/29 00:35 [pubmed] PHST- 2026/07/28 23:23 [entrez] PHST- 2026/07/29 00:00 [pmc-release] AID - 10.1007/s11892-026-01637-2 [pii] AID - 1637 [pii] AID - 10.1007/s11892-026-01637-2 [doi] PST - epublish SO - Curr Diab Rep. 2026 Jul 29;26(1):23. doi: 10.1007/s11892-026-01637-2. PMID- 42520924 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261022 IS - 2210-741X (Electronic) IS - 2210-7401 (Linking) VI - 50 IP - 8 DP - 2026 Oct TI - Sarcopenia in decompensated cirrhosis: a comparative analysis of bioelectrical impedance-based measures. PG - 102893 LID - S2210-7401(26)00139-7 [pii] LID - 10.1016/j.clinre.2026.102893 [doi] AB - BACKGROUND: Sarcopenia is highly prevalent in decompensated cirrhosis and strongly associated with adverse clinical outcomes. While bioelectrical impedance analysis (BIA) offers multiple body composition indices, the optimal approach remains uncertain. AIM: To evaluate the prevalence and comparative prognostic performance of Phase Angle (PA) versus other BIA-derived sarcopenia indices in patients with decompensated cirrhosis. METHODS: This prospective observational study included 155 patients with decompensated cirrhosis and ascites who underwent multi-frequency BIA. Sarcopenia was defined using sex-specific cutoffs for PA and four additional BIA-derived indices. Prognostic associations with mortality and infections were assessed through fully adjusted logistic and Cox regression models. RESULTS: Sarcopenia prevalence ranged between 40% and 50% across indices in the primary analysis. Although prevalence estimates were comparable, PA demonstrated superior prognostic performance. Low PA was independently associated with increased 12-month mortality (OR 2.28, 95% CI 1.52-3.42; p < 0.001) and infection risk (OR 1.95, 95% CI 1.32-2.88; p = 0.001), outperforming mass-based indices even after extensive adjustment. Each 1 degrees increase in PA was associated with a 29% reduction in mortality risk (HR 0.71, 95% CI 0.55-0.91; p = 0.008). These associations remained consistent across clinically relevant subgroups, including different ascites severities, Child-Pugh classes, and HCC status. PA also strongly predicted 90-day mortality and hospital readmissions. CONCLUSIONS: In patients with decompensated cirrhosis, PA provides significant added prognostic value beyond traditional BIA-derived muscle mass indices. This readily available bedside parameter may enhance risk stratification and support individualized nutritional and rehabilitative interventions. Its incremental utility warrants further validation in larger multicenter studies. CI - Copyright (c) 2026 Elsevier Masson SAS. All rights reserved. FAU - Elsabaawy, Maha AU - Elsabaawy M AD - Hepatology and Gastroenterology Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt; Therapeutic Nutrition Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt. Electronic address: maha.ahmed@liver.menofia.edu.eg. FAU - Ragab, Mohammed AU - Ragab M AD - Hepatology and Gastroenterology Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt. FAU - Al-Khalifa, Maymona AU - Al-Khalifa M AD - Therapeutic Nutrition Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt. FAU - Gamil, Khaled AU - Gamil K AD - Hepatology and Gastroenterology Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt. FAU - Elfayoumy, Marwa AU - Elfayoumy M AD - Hepatology and Gastroenterology Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt; Therapeutic Nutrition Department, National Liver Institute Menoufia University, Shebeen Elkoom, Egypt. LA - eng PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20260728 PL - France TA - Clin Res Hepatol Gastroenterol JT - Clinics and research in hepatology and gastroenterology JID - 101553659 SB - IM MH - Humans MH - *Sarcopenia/epidemiology/diagnosis/etiology/complications MH - *Electric Impedance MH - Female MH - *Liver Cirrhosis/complications/mortality MH - Male MH - Prospective Studies MH - Prognosis MH - Middle Aged MH - Prevalence MH - Aged MH - Ascites OTO - NOTNLM OT - Bioelectrical impedance analysis OT - Decompensated cirrhosis OT - Phase angle OT - Prognosis OT - Sarcopenia COIS- Declaration of competing interest The authors have no relevant financial or non-financial interests to disclose. EDAT- 2026/07/29 00:35 MHDA- 2026/10/16 23:33 CRDT- 2026/07/28 19:18 PHST- 2026/02/27 00:00 [received] PHST- 2026/07/23 00:00 [revised] PHST- 2026/07/27 00:00 [accepted] PHST- 2026/10/16 23:33 [medline] PHST- 2026/07/29 00:35 [pubmed] PHST- 2026/07/28 19:18 [entrez] AID - S2210-7401(26)00139-7 [pii] AID - 10.1016/j.clinre.2026.102893 [doi] PST - ppublish SO - Clin Res Hepatol Gastroenterol. 2026 Oct;50(8):102893. doi: 10.1016/j.clinre.2026.102893. Epub 2026 Jul 28. PMID- 42520891 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261020 IS - 2212-2672 (Print) IS - 2212-2672 (Linking) VI - 126 IP - 11 DP - 2026 Nov TI - Reliability and Validity of a Parent-Reported Diet Quality Screener for Young Children: The Rapid Prime Diet Quality Score for Kids. PG - 156425 LID - S2212-2672(26)00140-1 [pii] LID - 10.1016/j.jand.2026.156425 [doi] AB - BACKGROUND: Pediatric dietary assessment is challenging, particularly for young children who cannot accurately report their own intake. Many existing measures are burdensome for proxy-reporters, and briefer dietary screeners focus on specific dietary components but not total diet quality. OBJECTIVE: The objective of this study was to develop and evaluate the reliability and validity of an adapted brief parent-reported diet quality screener; that is, the rapid Prime Diet Quality Score for Kids (rPDQS-Kids), in relation to food groups and overall diet quality estimated from repeated Automated Self-Administered 24-Hour Dietary Assessment Tool (ASA24) diet recalls for young children. DESIGN: This was a cross-sectional study that evaluated the psychometric properties of the 16-item rPDQS-Kids. PARTICIPANTS/SETTING: Participants of this study included parents of children aged 1 to 4 years participating in the Special Supplemental Nutrition Program for Women, Infants, and Children (N = 175) in the state of Massachusetts from January 2024 to February 2025. MAIN OUTCOME MEASURES: Information about consumption frequencies was reported by parents using the rPDQS-Kids screener. Mean intake and overall diet quality were also assessed using 2 24-hour recalls. STATISTICAL ANALYSES PERFORMED: Test-retest reliability and internal consistency of the rPDQS-Kids were evaluated. Criterion validity was assessed by comparing the rPDQS-Kids diet quality score with the Healthy Eating Index (HEI) score (HEI-2020 for children aged 2 to 4 years or HEI-Toddlers-2020 for children aged 1 up to 2 years). RESULTS: The rPDQS-Kids showed moderate test-retest reliability (intraclass correlation coefficient for total score 0.69; 95% CI, 0.62 to 0.75). Consistent with a priori hypotheses, internal consistency reliability was low, with ordinal alpha = .27 and ordinal alpha = .34 for the healthy and unhealthy subscores, respectively. Further, a significant correlation was observed between the rPDQS-Kids traffic light diet quality score and HEI-2020 total score among children aged 2 to 4 years (r = 0.32) (P < .001) (n = 127). Among children aged 1 to 2 years (n = 48), rPDQS-Kids was not significantly correlated with the HEI-Toddlers-2020 (P > .05). CONCLUSIONS: The parent-reported rPDQS-Kids shows potential as a low-burden tool for measuring young children's dietary quality. CI - Copyright (c) 2026 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved. FAU - Hammad, Nour M AU - Hammad NM AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Electronic address: nourhammad@fas.harvard.edu. FAU - Zimmer, Meghan AU - Zimmer M AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. FAU - Mozaffarian, Rebecca S AU - Mozaffarian RS AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. FAU - Rimm, Eric B AU - Rimm EB AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts. FAU - Kenney, Erica L AU - Kenney EL AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. LA - eng PT - Journal Article PT - Validation Study DEP - 20260728 PL - United States TA - J Acad Nutr Diet JT - Journal of the Academy of Nutrition and Dietetics JID - 101573920 SB - IM MH - Humans MH - Female MH - Reproducibility of Results MH - Child, Preschool MH - Cross-Sectional Studies MH - Infant MH - Parents MH - Male MH - *Nutrition Assessment MH - *Diet/statistics & numerical data/standards MH - Psychometrics MH - *Diet Surveys/methods/standards MH - Massachusetts MH - *Diet, Healthy/statistics & numerical data MH - Mental Recall OTO - NOTNLM OT - Diet quality OT - Dietary assessment OT - PDQS OT - Preschool-aged children OT - WIC EDAT- 2026/07/29 00:35 MHDA- 2026/10/20 23:28 CRDT- 2026/07/28 19:18 PHST- 2025/05/01 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/10/20 23:28 [medline] PHST- 2026/07/29 00:35 [pubmed] PHST- 2026/07/28 19:18 [entrez] AID - S2212-2672(26)00140-1 [pii] AID - 10.1016/j.jand.2026.156425 [doi] PST - ppublish SO - J Acad Nutr Diet. 2026 Nov;126(11):156425. doi: 10.1016/j.jand.2026.156425. Epub 2026 Jul 28. PMID- 42520788 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260908 IS - 1476-1645 (Electronic) IS - 0002-9637 (Print) IS - 0002-9637 (Linking) VI - 115 IP - 3 DP - 2026 Sep 2 TI - Social Perceptions of Konzo Disease in Nampula Province, Mozambique. PG - 436-442 LID - 10.4269/ajtmh.26-0017 [doi] AB - Konzo, a neurodegenerative disease prevalent in Nampula Province, Mozambique, presents debilitating symptoms known locally as "mantakassa" ("that which breaks legs"). Although the biomedical literature attributes its cause to insufficiently processed cassava amid food insecurity, traditional narratives often cite supernatural explanations, like witchcraft. This review analyzed the existing literature to understand social perceptions of konzo, focusing on traditional leaders' perspectives and their implications for public health. It found that konzo cases cluster within families owing to shared dietary habits and socioeconomic vulnerabilities, disproportionately affecting women and children. Community narratives often link the disease to spiritual causes, differing from biomedical views. Health care workers noted low diagnostic accuracy and limited knowledge of the condition. Notably, the role of traditional healers, often the first line of care in rural areas, remains underdocumented, highlighting a critical knowledge gap. Further research into their understanding of konzo is essential for developing culturally sensitive health interventions and improving public health strategies. FAU - Raimundo, Litos AU - Raimundo L AD - Faculty of Science and Technology, Fernando Pessoa University, Porto, Portugal. FAU - Rodrigues, Daniela AU - Rodrigues D AD - CIAS-Research Centre for Anthropology and Health-Group of Human Biology, Health and Society, University of Coimbra, Coimbra, Portugal. AD - Department of Life Sciences, University of Coimbra, Coimbra, Portugal. FAU - Silva, Maria-Raquel G AU - Silva MG AD - CIAS-Research Centre for Anthropology and Health-Group of Human Biology, Health and Society, University of Coimbra, Coimbra, Portugal. AD - FP-I3ID and FCS-UFP-Faculty of Health Sciences, Fernando Pessoa University, Porto, Portugal. AD - Molecular Oncology and Viral Pathology Group, Research Centre of IPO-Porto (CI-IPOP) & RISE@CI-IPOP (Health Research Network), Portuguese Oncology Institute of Porto (IPO-Porto)/Porto Comprehensive Cancer Centre Raquel Seruca (Porto.CCC), Porto, Portugal. AD - CHRC-Comprehensive Health Research Centre-Group of Sleep, Chronobiology and Sleep Disorders, Nova Medical School, Nova University of Lisbon, Lisbon, Portugal. AD - RISE-Health, Fernando Pessoa University, Porto, Portugal. LA - eng PT - Journal Article PT - Review DEP - 20260728 PL - United States TA - Am J Trop Med Hyg JT - The American journal of tropical medicine and hygiene JID - 0370507 SB - IM MH - Humans MH - Health Knowledge, Attitudes, Practice MH - Mozambique/epidemiology MH - *Nervous System Diseases/epidemiology/psychology PMC - PMC13417359 COIS- Disclosures: The authors acknowledge the use of artificial intelligence tools, specifically Elicit and Microsoft Copilot, for literature exploration, organization of ideas, and language refinement. All conceptualization, analysis, interpretation, and final editorial decisions remain entirely the responsibility of the authors. The authors declare no conflicts of interest. EDAT- 2026/07/29 00:35 MHDA- 2026/09/03 01:19 PMCR- 2027/07/28 CRDT- 2026/07/28 18:32 PHST- 2026/01/13 00:00 [received] PHST- 2026/06/05 00:00 [accepted] PHST- 2026/09/03 01:19 [medline] PHST- 2026/07/29 00:35 [pubmed] PHST- 2026/07/28 18:32 [entrez] PHST- 2027/07/28 00:00 [pmc-release] AID - tpmd260017 [pii] AID - 10.4269/ajtmh.26-0017 [doi] PST - epublish SO - Am J Trop Med Hyg. 2026 Jul 28;115(3):436-442. doi: 10.4269/ajtmh.26-0017. Print 2026 Sep 2. PMID- 42520436 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260914 IS - 1872-6283 (Electronic) IS - 0379-0738 (Linking) VI - 388 DP - 2026 Nov TI - Diagnostic utility of the drowning index: A review of the literature and analysis of 7105 Danish autopsy cases. PG - 113075 LID - S0379-0738(26)00262-8 [pii] LID - 10.1016/j.forsciint.2026.113075 [doi] AB - BACKGROUND AND AIM: Drowning is a diagnosis of exclusion that relies on circumstantial scene- and autopsy findings. The drowning index (DI) was constructed in previous publications as a suggested aid in the diagnosis of drowning by relating lung weight to spleen weight. This study aimed to evaluate the diagnostic performance of the DI in distinguishing drowning from other causes of death associated with increased lung weight and a group of hanging deaths. METHODS: A retrospective cohort study was conducted using a database of 22,872 Danish autopsy cases, from which 7105 cases of either drowning, cardiac death, poisoning and hanging were selected. DI was calculated for each case. Descriptive statistics and group-wise comparison using Kruskal-Wallis with pairwise Wilcoxon post hoc testing, and receiver operating characteristic (ROC) analysis were performed. A literature review was conducted for comparison. RESULTS: Mean drowning index was significantly higher in drowning (n = 427) cases (15.48) compared with other causes of death (hanging: 8.89, heart failure: 10.24 and poisoning: 10.45). ROC analysis combined with Youden's index identified an optimal DI cut-off of approximately 11, corresponding to a sensitivity of 56% (CI: 51.1-60.7) and a specificity of 67.2% (CI: 66.1-68.4). Findings from the literature review were broadly comparable. CONCLUSION: In this largest study of the DI to date, we propose that the DI is best interpreted as a graded measure of evidential strength for drowning as a cause of death, rather than a dichotomous diagnostic marker. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Jorgensen, Kristian Brochner AU - Jorgensen KB AD - Department of Forensic Medicine, University of Copenhagen, Frederik V's Vej 11, Copenhagen 2100, Denmark. Electronic address: tzs584@alumni.ku.dk. FAU - Busch, Johannes Rodbro AU - Busch JR AD - Department of Forensic Medicine, University of Copenhagen, Frederik V's Vej 11, Copenhagen 2100, Denmark. FAU - Wingren, Carl Johan AU - Wingren CJ AD - Department of Forensic Medicine, University of Copenhagen, Frederik V's Vej 11, Copenhagen 2100, Denmark. LA - eng PT - Journal Article PT - Review DEP - 20260724 PL - Ireland TA - Forensic Sci Int JT - Forensic science international JID - 7902034 SB - IM MH - Humans MH - *Drowning/diagnosis MH - Denmark/epidemiology MH - Retrospective Studies MH - Lung/pathology MH - Spleen/pathology MH - Organ Size MH - Female MH - ROC Curve MH - Male MH - Middle Aged MH - Adult MH - Neck Injuries/mortality/diagnosis/pathology MH - Asphyxia/diagnosis/mortality MH - Sensitivity and Specificity MH - Forensic Pathology MH - Aged MH - Poisoning/diagnosis MH - Adolescent MH - Young Adult MH - Aged, 80 and over OTO - NOTNLM OT - Drowning OT - Drowning index OT - Forensic pathology OT - Postmortem diagnostics COIS- Declaration of Competing Interest The authors have no competing interests to declare that are relevant to the content of this article. EDAT- 2026/07/29 00:35 MHDA- 2026/09/09 23:36 CRDT- 2026/07/28 18:04 PHST- 2026/05/28 00:00 [received] PHST- 2026/07/22 00:00 [revised] PHST- 2026/07/23 00:00 [accepted] PHST- 2026/09/09 23:36 [medline] PHST- 2026/07/29 00:35 [pubmed] PHST- 2026/07/28 18:04 [entrez] AID - S0379-0738(26)00262-8 [pii] AID - 10.1016/j.forsciint.2026.113075 [doi] PST - ppublish SO - Forensic Sci Int. 2026 Nov;388:113075. doi: 10.1016/j.forsciint.2026.113075. Epub 2026 Jul 24. PMID- 42520377 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260930 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 204 DP - 2026 Nov TI - Radiological evaluation of the natural history of PIK3CA-related overgrowth spectrum (PROS). PG - 113108 LID - S0720-048X(26)00456-0 [pii] LID - 10.1016/j.ejrad.2026.113108 [doi] AB - PURPOSE: PIK3CA-related overgrowth spectrum (PROS) comprises a heterogeneous group of disorders caused by postzygotic activating variants in PIK3CA, leading to mosaic activation of the PI3K pathway. The natural history of PROS is highly variable and depends on the timing and distribution of the somatic mutation. To better characterize its radiological progression, we analyzed a cohort of patients with PROS. METHODS: This multicenter study was conducted at Hopital Femme Mere Enfant (Lyon) and Hopital Necker-Enfants Malades (Paris). Pediatric and adult patients with a confirmed PIK3CA variant and at least two MRI examinations performed >/= 2 months apart were included. Patients who underwent interventional surgical or radiological procedures, or who received targeted therapies, were excluded. Target lesions were identified on baseline MRI and evaluated on follow-up scans according to RECIST criteria. RESULTS: Among 67 PROS patients screened between 2008 and 2021, 30 met the inclusion criteria, including 43.3 % children (13/30) and 43.3 % females (13/30). The median age at first MRI was 19 years (interquartile range 5-34). Lesions involved the head and neck region (10/30), trunk and upper limbs (10/30), and lower limbs (10/30), with some patients presenting multisite involvement. Over a median follow-up of 75.7 months (range 2.1-160.3), 83.3 % (n = 25) of patients had progressive disease, with a median increase of 36.6 % in lesion size (range 2.6-230.7 %) and a median annualized growth rate of 7.2 %/year (range 0.6-40.1 %). CONCLUSION: This study provides the first radiological description of PROS natural history, showing that tissue malformations generally enlarge over time and often continue progressing into adulthood. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Fraissenon, Antoine AU - Fraissenon A AD - INSERM U1151, Institut Necker-Enfants Malades, Paris, France; Centre de Reference des Anomalies Vasculaires Superficielles, Imagerie Pediatrique, hopital Femme-Mere-Enfant, HCL, Bron, France; CREATIS UMR 5220, Villeurbanne, France; Service de Radiologie Mere-Enfant, hopital Nord, Saint Etienne, France. FAU - Morin, Gabriel AU - Morin G AD - INSERM U1151, Institut Necker-Enfants Malades, Paris, France; Universite Paris Cite, Paris, France; Unite de Medecine Translationnelle et Therapies Ciblees, Hopital Necker-Enfants Malades, AP-HP, Paris, France; Centre d'Investigation Clinique - Unite de Recherche Clinique Mere-Enfant Necker-Cochin, Hopital Necker-Enfants Malades, AP-HP, Paris, France. FAU - Boddaert, Nathalie AU - Boddaert N AD - Universite Paris Cite, Paris, France; Institut Imagine INSERM U1163, F-75015 Paris France; Paediatric Radiology Department, AP-HP, Hopital Necker Enfants Malades, Paris France. FAU - Loiselet, Klervie AU - Loiselet K AD - Institut Imagine INSERM U1163, F-75015 Paris France; Paediatric Radiology Department, AP-HP, Hopital Necker Enfants Malades, Paris France. FAU - Berteloot, Laureline AU - Berteloot L AD - Institut Imagine INSERM U1163, F-75015 Paris France; Paediatric Radiology Department, AP-HP, Hopital Necker Enfants Malades, Paris France. FAU - Guibaud, Laurent AU - Guibaud L AD - INSERM U1151, Institut Necker-Enfants Malades, Paris, France; Centre de Reference des Anomalies Vasculaires Superficielles, Imagerie Pediatrique, hopital Femme-Mere-Enfant, HCL, Bron, France. FAU - Canaud, Guillaume AU - Canaud G AD - INSERM U1151, Institut Necker-Enfants Malades, Paris, France; Universite Paris Cite, Paris, France; Unite de Medecine Translationnelle et Therapies Ciblees, Hopital Necker-Enfants Malades, AP-HP, Paris, France; Centre d'Investigation Clinique - Unite de Recherche Clinique Mere-Enfant Necker-Cochin, Hopital Necker-Enfants Malades, AP-HP, Paris, France. Electronic address: guillaume.canaud@inserm.fr. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260724 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 RN - EC 2.7.1.137 (PIK3CA protein, human) RN - EC 2.7.1.137 (Class I Phosphatidylinositol 3-Kinases) RN - EC 2.7.1.- (Phosphatidylinositol 3-Kinases) SB - IM MH - Humans MH - Female MH - Class I Phosphatidylinositol 3-Kinases/genetics MH - *Magnetic Resonance Imaging/methods MH - Child MH - Child, Preschool MH - Adult MH - Male MH - Adolescent MH - Young Adult MH - *Phosphatidylinositol 3-Kinases/genetics MH - Genetic Predisposition to Disease/genetics/epidemiology MH - *Growth Disorders/genetics MH - Reproducibility of Results MH - Sensitivity and Specificity COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Dr. Canaud receives or has received consulting fees from Novartis, Fresenius Medical Care, Vaderis, Alkermes, IPSEN and BridgeBio. EDAT- 2026/07/29 00:35 MHDA- 2026/09/26 05:34 CRDT- 2026/07/28 18:02 PHST- 2026/06/12 00:00 [received] PHST- 2026/07/17 00:00 [revised] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/09/26 05:34 [medline] PHST- 2026/07/29 00:35 [pubmed] PHST- 2026/07/28 18:02 [entrez] AID - S0720-048X(26)00456-0 [pii] AID - 10.1016/j.ejrad.2026.113108 [doi] PST - ppublish SO - Eur J Radiol. 2026 Nov;204:113108. doi: 10.1016/j.ejrad.2026.113108. Epub 2026 Jul 24. PMID- 42519260 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 6 DP - 2026 Jun TI - Admission Respiratory Rate-Oxygenation Index and Outcome of Acute Respiratory Illness in a Pediatric Intensive Care Unit. PG - e111005 LID - 10.7759/cureus.111005 [doi] LID - e111005 AB - Background Acute respiratory illness (ARI) remains a leading cause of pediatric intensive care unit (PICU) admissions and mortality in low- and middle-income countries. Early identification of children at risk of deterioration or ventilatory support is essential to improve outcomes. The Respiratory Rate-Oxygenation (ROX) Index, defined as (peripheral oxygen saturation (SpO(2))/fraction of inspired oxygen (FiO(2)))/respiratory rate, is a non-invasive bedside tool validated in adults with respiratory failure; however, pediatric evidence is scarce. Objectives To evaluate the association of admission ROX Index with (1) mortality and (2) the requirement for positive-pressure ventilation (PPV) among children with ARI admitted to the PICU. Methods A prospective observational study was conducted among 200 consecutively admitted children aged two months to five years with ARI at a tertiary-care hospital. Demographic, anthropometric, and physiological parameters were recorded at admission. The ROX index was computed as (SpO(2)/FiO(2))/respiratory rate. Primary outcomes were in-hospital mortality and need for PPV. Data were analyzed using non-parametric tests and receiver operating characteristic (ROC) analysis; p<0.05 was considered significant (STATA v14; StataCorp LLC, College Station, TX, US). Results The median age was seven months (IQR 4-12); 131 (65.5%) were male patients, and severe undernutrition (weight-for-age Z-score <-3 SD) was observed in 36 (18%) children. Overall mortality was 7% (14/200). The median admission ROX index was lower among non-survivors (5.6 (5.2-6.4)) than survivors (6.3 (5.9-7.1); p=0.002). The ROX index showed moderate discrimination for mortality (AUC=0.746; 95% CI 0.62-0.87) with an optimal cut-off 0.05). SHAP and TabNet analyses highlighted screen time, sleep duration, parental obesity, physical activity and diet as key predictors. CONCLUSION: The GenAI-enhanced stacking ensemble model accurately predicts adolescent obesity, with strong calibration and interpretability. It identifies behavioural and familial determinants, supporting school and community deployment for early detection and prevention. CI - Copyright (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. Published by BMJ Group. FAU - Rakshitha, Jayashankar AU - Rakshitha J AUID- ORCID: 0000-0002-2011-1790 AD - Department Of Community Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. FAU - Sunil Kumar, Doddaiah AU - Sunil Kumar D AUID- ORCID: 0000-0001-8755-3975 AD - Department Of Community Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. FAU - Santhosh Kumar, M AU - Santhosh Kumar M AD - Department of Pediatrics, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. FAU - Arun, Vanishri AU - Arun V AD - Department of Information Science and Engineering, JSS Science and Technology University, Mysuru, Karnataka, India. FAU - Krishnamurthy, Kamidi Venkatesh AU - Krishnamurthy KV AUID- ORCID: 0000-0003-4433-8567 AD - Department Of Community Medicine, JSS Medical College, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. LA - eng PT - Journal Article DEP - 20260723 PL - England TA - BMJ Public Health JT - BMJ public health JID - 9918697578906676 PMC - PMC13405018 OTO - NOTNLM OT - Adolescent OT - Body Mass Index OT - Obesity OT - Risk Assessment COIS- None declared. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/23 CRDT- 2026/07/28 04:39 PHST- 2025/12/02 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 04:39 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - bmjph-2025-004650 [pii] AID - 10.1136/bmjph-2025-004650 [doi] PST - epublish SO - BMJ Public Health. 2026 Jul 23;4(3):e004650. doi: 10.1136/bmjph-2025-004650. eCollection 2026. PMID- 42516461 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260927 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 6 DP - 2026 Jun TI - Intimate Partner Violence and Childhood Nutritional Outcomes in Madhya Pradesh: Secondary Analysis of National Family Health Survey-5 (NFHS-5) Data. PG - e111586 LID - 10.7759/cureus.111586 [doi] LID - e111586 AB - BACKGROUND: Intimate partner violence (IPV) and childhood undernutrition represent co-occurring public health challenges in Madhya Pradesh (MP), India. This study examined the association between maternal IPV exposure and child health outcomes, including stunting, wasting, and underweight, using data from the National Family Health Survey-5 (NFHS-5), 2019-21. METHOD: A cross-sectional secondary data analysis was conducted using NFHS-5 Individual Recode and Children's Recode files for MP. The files were merged at the household level, yielding 1,820 mother-child pairs. IPV was assessed using the validated domestic violence (DV) module (n=4,519 women in the 50% subsample). Child outcomes were defined using WHO anthropometric Z-scores. Multivariable binary logistic regression estimated adjusted odds ratios (aOR) with 95% confidence intervals (CIs), adjusting for exogenous sociodemographic confounders, including place of residence, maternal education, wealth index, and maternal age. Demographic and Health Surveys (DHS) sampling weights were applied throughout. RESULTS: IPV prevalence was 28.3% among the DV subsample. Stunting, wasting, and underweight were observed in 36.4%, 18.7%, and 33.4% of children, respectively. After adjustment, IPV was not independently associated with stunting (aOR=1.071, 95% CI: 0.833-1.376, p=0.592), wasting (aOR=0.825, 95% CI: 0.601-1.132, p=0.234), or underweight (aOR=0.912, 95% CI: 0.708-1.174, p=0.475). The household wealth index emerged as the dominant, strongly protective independent predictor across all child health metrics (stunting and underweight: p<0.001; wasting: p=0.017). CONCLUSION: IPV and pediatric malnutrition represent concurrent, intersecting vulnerabilities within MP, but structural poverty is the primary independent predictor of anthropometric failure. Effective policy responses must shift beyond isolated vertical programmes, integrating gender-based violence prevention within maternal and child health platforms alongside robust household economic empowerment. CI - Copyright (c) 2026, Adhikari et al. FAU - Adhikari, Shubhankar AU - Adhikari S AD - Community Medicine, Chirayu Medical College & Hospital, Bhopal, IND. FAU - Mishra, Jaya AU - Mishra J AD - Community Medicine, Chirayu Medical College & Hospital, Bhopal, IND. FAU - Singh, Siddharth AU - Singh S AD - Community Medicine, Chirayu Medical College & Hospital, Bhopal, IND. LA - eng PT - Journal Article DEP - 20260626 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13402441 OTO - NOTNLM OT - child nutrition OT - demographic and health survey OT - domestic violence OT - india OT - intimate partner violence OT - nfhs-5 OT - population-based dataset OT - poshan abhiyaan OT - stunting OT - wasting COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/07/28 06:36 MHDA- 2026/07/28 06:37 PMCR- 2026/06/26 CRDT- 2026/07/28 04:37 PHST- 2026/06/26 00:00 [accepted] PHST- 2026/07/28 06:37 [medline] PHST- 2026/07/28 06:36 [pubmed] PHST- 2026/07/28 04:37 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 10.7759/cureus.111586 [doi] PST - epublish SO - Cureus. 2026 Jun 26;18(6):e111586. doi: 10.7759/cureus.111586. eCollection 2026 Jun. PMID- 42516430 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2296-4185 (Print) IS - 2296-4185 (Electronic) IS - 2296-4185 (Linking) VI - 14 DP - 2026 TI - Scaling correction in pediatric center-of-pressure analysis: a dual-track computational framework for standardized balance assessment. PG - 1857252 LID - 10.3389/fbioe.2026.1857252 [doi] LID - 1857252 AB - OBJECTIVE: In this study, we developed and validated a standardized computational framework for pediatric balance assessment by integrating anthropometric normalization and a dual-track analytical architecture into a unified center-of-pressure (COP) signal-processing pipeline. METHODS: This study included 90 typically developing children. They were stratified into age groups of 4, 6, and 10 years (n = 30 per group), balanced by sex. The children performed bipedal stance tasks under eyes-open and eyes-closed conditions. Static balance was assessed using a Zebris force platform (120 Hz). COP sway area, mediolateral displacement, and anteroposterior displacement were measured. Two parallel datasets were processed that included raw COP signals and leg length-normalized COP signals. Both datasets were subjected to 2 (sex) x 3 (age) analysis of variance to evaluate scaling sensitivity. Coefficients of variation were computed to assess system-level dispersion. RESULTS: Anthropometric normalization markedly increased parameter sensitivity. Under the eyes-open condition, normalized COP sway area and anteroposterior displacement revealed age effects not detectable in the raw dataset, indicating scaling bias in uncorrected COP signals. The dual-track comparison confirmed that normalization functions as a computational validation component rather than a statistical add-on. For most COP parameters, the coefficients of variation exceeded 50%, indicating substantial interindividual variability consistent with developmental heterogeneity rather than measurement error. CONCLUSION: The proposed framework advances pediatric balance assessment from a descriptive developmental comparison to a standardized, bias-aware signal-processing architecture. By integrating anthropometric scaling correction and dual-track validation into a unified COP signal-processing pipeline, the framework enhances scaling sensitivity, inferential validity, and reproducibility. It is readily deployable within intelligent clinical screening systems and supports the development of age-stratified reference databases and early detection algorithms for pediatric neuromotor assessment. CI - Copyright (c) 2026 Sha, Lin and Chiu. FAU - Sha, Liwa AU - Sha L AD - Department of Sports Training, Jilin Sport University, Changchun, Jilin, China. AD - Department of Education and Learning Technology, National Tsing Hua University, Hsinchu, Taiwan. FAU - Lin, Tzu-Cheng AU - Lin TC AD - Department of Kinesiology, National Tsing Hua University, Hsinchu, Taiwan. FAU - Chiu, Wen Hsin AU - Chiu WH AD - Department of Kinesiology, National Tsing Hua University, Hsinchu, Taiwan. LA - eng PT - Journal Article DEP - 20260713 PL - Switzerland TA - Front Bioeng Biotechnol JT - Frontiers in bioengineering and biotechnology JID - 101632513 PMC - PMC13402384 OTO - NOTNLM OT - anthropometric normalization OT - center of pressure OT - computational validation OT - dual-track analysis OT - pediatric postural control OT - scaling correction OT - stabilometry COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/13 CRDT- 2026/07/28 04:37 PHST- 2026/04/16 00:00 [received] PHST- 2026/06/16 00:00 [revised] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 04:37 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - 1857252 [pii] AID - 10.3389/fbioe.2026.1857252 [doi] PST - epublish SO - Front Bioeng Biotechnol. 2026 Jul 13;14:1857252. doi: 10.3389/fbioe.2026.1857252. eCollection 2026. PMID- 42516262 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260921 IS - 1939-795X (Print) IS - 1939-795X (Electronic) IS - 1939-795X (Linking) VI - 19 IP - 2 DP - 2026 TI - Qualities of Effective Nutrition Education Interventions in Athletes: A Systematic Review and Meta-Analysis. PG - 2015 LID - 10.70252/IJES2026215 [doi] LID - 2015 AB - Nutrition knowledge (NK) is consistently reported as low among athletes, potentially limiting optimal dietary intake, performance, recovery, and overall health outcomes. Sports dietitians have a responsibility to provide effective nutrition education and increase NK in athletes. Nutrition education interventions have been shown to improve NK, but practical application standards for designing and conducting nutrition interventions in athletes has yet to be established. The purpose of this meta-analysis is to measure the overall effect of nutrition education interventions on NK in athletes and identify characteristics of nutrition education interventions that effectively increase NK. Seven databases (Academic Search Premier, SPORTDiscus, MEDLINE, ERIC, Health Source: Nursing/Academic Edition, CINAHL Plus with Full Text, and Consumer Health Complete) were searched, yielding 125 studies. Fourteen studies met inclusion criteria and represented 755 athletes (ages 10-32) from various sports. SPSS was utilized to perform the meta-analysis with a random-effects model and DerSimonian-Laird procedure, and effect size (ES) estimates were expressed as Hedges' g. The overall ES of nutrition education intervention on NK was .949 (p < .001, 95% CI [.728, 1.171]), indicating a large statistically significant positive effect. Moderator analyses indicated that study design (Q = 12.577, p < .001), mode of intervention (Q = 17.479, p < .001), length (Q = 12.029, p = .002), and use of validated NK survey (Q = 19.430, p < .001) significantly influenced variation in ES. No significant differences were found for intervention type and participant age. Funnel plot asymmetry suggests potential publication bias, although Egger's test was nonsignificant (p = .897). Findings support the overall effectiveness of nutrition education interventions and provide practical insight into factors that may contribute to their success. FAU - Boyum, Lara AU - Boyum L AD - Department of Nutrition and Hospitality Management, University of Mississippi, Oxford, MS, USA. AD - Center for Health & Sports Performance, University of Mississippi, Oxford, MS, USA. FAU - Gilmore, Brooke AU - Gilmore B AD - Department of Nutrition and Hospitality Management, University of Mississippi, Oxford, MS, USA. AD - Center for Health & Sports Performance, University of Mississippi, Oxford, MS, USA. FAU - Franks, Corbit AU - Franks C AD - Center for Health & Sports Performance, University of Mississippi, Oxford, MS, USA. AD - Department of Health, Exercise Science, & Recreation Management, University of Mississippi, Oxford, MS, USA. AD - Human Movement & High-Performance Lab, University of Mississippi, Oxford, MS, USA. FAU - Kang, Minsoo AU - Kang M AD - Center for Health & Sports Performance, University of Mississippi, Oxford, MS, USA. AD - Health & Sport Analytics Laboratory, University of Mississippi, Oxford, MS, USA. LA - eng PT - Journal Article PT - Review DEP - 20260601 PL - United States TA - Int J Exerc Sci JT - International journal of exercise science JID - 101513127 PMC - PMC13405668 OTO - NOTNLM OT - Sports nutrition OT - adolescent athlete OT - performance outcomes OT - registered dietitian EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/06/01 CRDT- 2026/07/28 04:35 PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 04:35 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - ijes-19-2-15 [pii] AID - 10.70252/IJES2026215 [doi] PST - epublish SO - Int J Exerc Sci. 2026 Jun 1;19(2):2015. doi: 10.70252/IJES2026215. eCollection 2026. PMID- 42516205 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260904 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - How is mental health associated with teenagers' attitudes toward sport participation? - The chain mediating role of exercise self-efficacy and sport confidence. PG - 1892031 LID - 10.3389/fpsyg.2026.1892031 [doi] LID - 1892031 AB - PURPOSE: To elucidate the intrinsic psychological dynamics through which Mental Health is associated with Sport Participation Attitudes in adolescents, this study examines its direct and indirect effects through Exercise Self-Efficacy and Sport Confidence, developing a chained mediation model. METHODS: A stratified cluster sampling method was employed to select 1,384 adolescents aged 12-18 from Hunan Province as research subjects. A validated questionnaire was administered, and data were analyzed using SPSS and the PROCESS macro. RESULTS: Adolescent mental health has a significant positive association with attitudes toward sport participation, and exercise self-efficacy and sport confidence partly explain its effects as mediators. A significant chain mediation path is established between exercise self-efficacy and sport confidence, suggesting that mental health is associated with adolescents' sport participation attitudes through improving exercise self-efficacy and subsequently strengthening sport confidence. CONCLUSION: This study clarifies the hierarchical psychological transmission mechanisms by which mental health is associated with adolescents' sport participation attitudes, and identifies the progressive relationships of cognitive belief variables. These findings provide empirical evidence for adolescent mental health education, the optimization of campus sports teaching, and interventions in sport participation attitudes. CI - Copyright (c) 2026 Qiu, Liu, Zhang, Chen and Huang. FAU - Qiu, Jie AU - Qiu J AD - Hunan Mechanical and Electrical Polytechnic, Changsha, China. FAU - Liu, Mengfen AU - Liu M AD - Hunan Mechanical and Electrical Polytechnic, Changsha, China. FAU - Zhang, Guiyun AU - Zhang G AD - Hunan Mechanical and Electrical Polytechnic, Changsha, China. FAU - Chen, Jiawei AU - Chen J AD - Hunan Mechanical and Electrical Polytechnic, Changsha, China. FAU - Huang, Haoyan AU - Huang H AD - Faculty of Educational Sciences, University of Helsinki, Helsinki, Finland. LA - eng PT - Journal Article DEP - 20260713 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 EIN - Front Psychol. 2026 Aug 20;17:1940329. doi: 10.3389/fpsyg.2026.1940329. PMID: 42694509 PMC - PMC13402194 OTO - NOTNLM OT - exercise self-efficacy OT - mental health OT - sport confidence OT - sport participation attitudes OT - teenagers COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/13 CRDT- 2026/07/28 04:34 PHST- 2026/05/26 00:00 [received] PHST- 2026/06/16 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 04:34 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1892031 [doi] PST - epublish SO - Front Psychol. 2026 Jul 13;17:1892031. doi: 10.3389/fpsyg.2026.1892031. eCollection 2026. PMID- 42515770 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 1424-8247 (Print) IS - 1424-8247 (Electronic) IS - 1424-8247 (Linking) VI - 19 IP - 7 DP - 2026 Jul 15 TI - Advancing Pediatric Dose Scaling: Strategies, Modeling Approaches, and Clinical Applications. LID - 10.3390/ph19071090 [doi] LID - 1090 AB - Background/Objectives: Selecting appropriate doses for pediatric patients remains one of the most complex challenges in drug development because developmental changes in physiology, metabolism, organ function, and pharmacodynamics substantially influence drug exposure and response. This review summarizes current evidence-based approaches to pediatric dose selection across the developmental continuum and evaluates contemporary model-informed strategies for individualized dosing. Methods: A narrative review of the literature was conducted focusing on pediatric dose-scaling methodologies, developmental pharmacology, physiologically based pharmacokinetic (PBPK) modeling, population pharmacokinetic (PopPK) approaches, exposure-response analysis, therapeutic drug monitoring, and regulatory extrapolation frameworks. Special populations and clinical scenarios relevant to pediatric dose optimization were also evaluated. Results: Simple body weight-based scaling from adult doses inadequately accounts for developmental changes in drug disposition and response. Allometric scaling combined with maturation functions provides improved dose prediction in neonates and infants, while PBPK and PopPK modeling support mechanistic and data-driven dose optimization across pediatric age groups. Fat-free-mass (FFM)-based scaling is preferred over total body weight for many drugs in children with obesity. Additional considerations including obesity, biologics, formulation and excipient safety, pharmacogenomics, critical illness, therapeutic hypothermia, extracorporeal support, therapeutic drug monitoring, and drug-drug interactions substantially influence pediatric dosing strategies. Regulatory frameworks including ICH E11A increasingly support model-informed pediatric extrapolation and precision dosing approaches. Conclusions: Pediatric dose selection has evolved from empirical weight-based dosing toward integrated model-informed strategies incorporating developmental physiology, pharmacometrics, and regulatory science. Allometry, maturation functions, FFM-based scaling, PBPK, PopPK, and therapeutic drug monitoring provide complementary tools for rational pediatric dose optimization, although drug- and pathway-specific validation remains essential, particularly in neonates and critically ill children. FAU - Kudgus Lokken, Rachel A AU - Kudgus Lokken RA AD - Allucent, Cary, NC 27513, USA. FAU - Illamola, Silvia M AU - Illamola SM AD - Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. FAU - Job, Kathleen M AU - Job KM AUID- ORCID: 0000-0003-0255-654X AD - Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA. FAU - Al-Sallami, Hesham S AU - Al-Sallami HS AUID- ORCID: 0000-0002-0685-327X AD - College of Pharmacy, QU Health, Qatar University, Doha P.O. Box 2713, Qatar. FAU - 't Jong, Geert W AU - 't Jong GW AD - Children's Hospital Research Institute of Manitoba, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB R3E 3P4, Canada. FAU - Reith, David M AU - Reith DM AUID- ORCID: 0000-0002-2447-365X AD - Faculty of Medicine, University of Otago, Dunedin 9054, New Zealand. FAU - Birnbaum, Angela K AU - Birnbaum AK AUID- ORCID: 0000-0002-3969-4906 AD - Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. AD - Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA. AD - Center for Clinical and Cognitive Neuropharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. AD - Department of Medical Laboratory Sciences, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. FAU - Sherwin, Catherine M AU - Sherwin CM AUID- ORCID: 0000-0002-0844-3207 AD - Department of Experimental and Clinical Pharmacology, College of Pharmacy, University of Minnesota, Minneapolis, MN 55455, USA. AD - Division of Clinical Pharmacology, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT 84108, USA. AD - Internal Medicine, UWA Medical School, The University of Western Australia, Perth, WA 6009, Australia. AD - Differentia Biotech Ltd., South San Francisco, CA 94080, USA. AD - Department of Pharmacology and Toxicology, Wright State University Boonshoft School of Medicine, Dayton, OH 45435, USA. LA - eng PT - Journal Article PT - Review DEP - 20260715 PL - Switzerland TA - Pharmaceuticals (Basel) JT - Pharmaceuticals (Basel, Switzerland) JID - 101238453 PMC - PMC13415250 OTO - NOTNLM OT - PBPK modeling OT - allometric scaling OT - dose scaling OT - model-informed drug development (MIDD) OT - neonatal OT - ontogeny OT - pediatric pharmacokinetics OT - pharmacometrics OT - population pharmacokinetics COIS- R.A.K.L. is an employee of Allucent, Cary, NC, USA. C.M.S. is an employee of Differentia Biotech Ltd. but has no stocks, equity, or financial interests in the company. C.M.S. is a Guest Editor for Pharmaceuticals; however, she was not involved in the peer review process or editorial decision-making for this manuscript. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as potential conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/15 CRDT- 2026/07/28 01:23 PHST- 2026/05/29 00:00 [received] PHST- 2026/07/05 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:23 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - ph19071090 [pii] AID - pharmaceuticals-19-01090 [pii] AID - 10.3390/ph19071090 [doi] PST - epublish SO - Pharmaceuticals (Basel). 2026 Jul 15;19(7):1090. doi: 10.3390/ph19071090. PMID- 42514449 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 21 TI - Estimation of Cardiometabolic Risk in Turkish Adolescents Using Different Anthropometric Techniques: Development and Temporal Validation of a Machine Learning Model. LID - 10.3390/nu18142380 [doi] LID - 2380 AB - BACKGROUND: Although obesity is a recognized cardiometabolic risk determinant, debate persists over the most appropriate anthropometric technique. This study evaluated different anthropometric techniques for predicting cardiometabolic risk in Turkish adolescents and aimed to develop and temporally validate a machine learning-based prediction model, reported in accordance with the TRIPOD statement. METHODS: Adolescents from the Turkiye Nutrition and Health Survey in 2010 (n = 1357) and 2017 (n = 561) were included. Anthropometric and biochemical parameters were assessed. BMI z-scores, waist-to-hip and waist-to-height ratios, triponderal mass index (TMI), visceral adiposity index (VAI), and lipid accumulation product (LAP) were calculated. RESULTS: In ROC analysis, VAI showed the highest discrimination (AUC = 0.747, p < 0.001), followed by LAP (AUC = 0.670). In machine learning, XGBoost achieved the highest training discrimination (ROC-AUC = 0.879), whereas logistic regression was the most stable, with minimal overfitting (DeltaAUC = 0.008). The logistic regression model was well calibrated (Brier score = 0.107; calibration slope 1.00 development, 1.03 external). External temporal validation showed comparable discrimination across models (AUC = 0.742-0.757), with logistic regression showing the greatest consistency. The model showed a high negative predictive value (NPV = 91.7%) and was therefore better suited to ruling out than ruling in cardiometabolic risk; positive findings warrant confirmatory testing (PPV = 35.4%). A simple logistic-based formula was derived. CONCLUSIONS: Machine learning approaches, together with the developed model and simplified formula, may be useful tools for estimating cardiometabolic risk in adolescents and could support a stepwise screening strategy, pending recalibration and prospective validation. FAU - Kahriman, Meryem AU - Kahriman M AUID- ORCID: 0000-0002-6908-7381 AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Turkiye. FAU - Cakir Bicer, Nihan AU - Cakir Bicer N AUID- ORCID: 0000-0002-7581-9083 AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Turkiye. AD - Department of Molecular Gastroenterology and Hepatology, Institute of Gastroenterology and Hepatology, Kocaeli University, 41001 Kocaeli, Turkiye. FAU - Bas, Murat AU - Bas M AUID- ORCID: 0000-0002-0494-301X AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Turkiye. AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20260721 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Turkey/epidemiology MH - Adolescent MH - Female MH - Male MH - Predictive Learning Models MH - *Machine Learning MH - *Anthropometry/methods MH - *Cardiometabolic Risk Factors MH - *Cardiovascular Diseases/epidemiology/etiology/diagnosis MH - Body Mass Index MH - Logistic Models MH - Risk Assessment/methods MH - ROC Curve MH - Risk Factors MH - Classification Algorithms PMC - PMC13415240 OTO - NOTNLM OT - body mass index OT - cardiometabolic risk OT - lipid accumulation product index OT - triponderal mass index OT - visceral adiposity index COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/21 CRDT- 2026/07/28 01:18 PHST- 2026/06/23 00:00 [received] PHST- 2026/07/16 00:00 [revised] PHST- 2026/07/17 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - nu18142380 [pii] AID - nutrients-18-02380 [pii] AID - 10.3390/nu18142380 [doi] PST - epublish SO - Nutrients. 2026 Jul 21;18(14):2380. doi: 10.3390/nu18142380. PMID- 42514416 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 17 TI - Metabolomic Profiling of Plasma in Children with Drug-Resistant Epilepsy: The Effect of the Ketogenic Diet on Energy and Amino Acid Pathways. LID - 10.3390/nu18142347 [doi] LID - 2347 AB - BACKGROUND: Drug-resistant epilepsy in children remains a major therapeutic challenge, and the limited efficacy of pharmacological treatment highlights the need for alternative therapeutic approaches, including the ketogenic diet (KD). Although the clinical efficacy of KD is well established, its metabolic effects are not fully understood. This study aimed to characterize the plasma metabolomic profile of children with drug-resistant epilepsy and to explore metabolic differences associated with ketogenic dietary therapy. METHODS: Eighteen children with drug-resistant epilepsy were enrolled, including nine receiving KD and nine receiving a standard diet. Plasma metabolomic profiling was performed using gas chromatography-mass spectrometry (GC-MS). Data were analyzed using multivariate (PCA and OPLS-DA) and univariate statistical approaches. Both variable importance in projection (VIP) scores and metabolic pathway analysis were used to support biological interpretation. RESULTS: A total of 462 annotated GC-MS features were retained after data filtering. OPLS-DA demonstrated clear separation between study groups (R(2)Y = 0.937; Q(2) = 0.594). Eighty-three metabolites had VIP scores > 1, indicating a substantial contribution to the OPLS-DA model, while 22 metabolites differed between groups based on unadjusted p-values. However, only three metabolites remained statistically significant after false discovery rate correction. After false discovery rate correction, beta-hydroxybutyrate and citric acid remained significantly higher in the KD group, whereas 1,4-butanediol was significantly lower. Lower glucose and tryptophan levels were observed only in the unadjusted analyses and should therefore be regarded as exploratory. Similarly, the pathway analysis findings, including those related to amino acid metabolism, were exploratory and require confirmation in larger cohorts. CONCLUSIONS: Ketogenic dietary therapy was associated with distinct changes in the plasma metabolomic profile of children with drug-resistant epilepsy. While the most robust findings involved beta-hydroxybutyrate, citric acid, and 1,4-butanediol, the observed changes in glucose and tryptophan, as well as the amino acid-related pathway findings, should be considered exploratory and require validation in larger independent cohorts before being interpreted as biomarkers or evidence of specific metabolic mechanisms. FAU - Cieslak, Marta AU - Cieslak M AD - Institute of General and Environmental Chemistry, Faculty of Chemistry, Lodz University of Technology, 116 Zeromskiego Street, 90-924 Lodz, Poland. FAU - Gatarek, Paulina AU - Gatarek P AUID- ORCID: 0009-0006-3825-522X AD - Institute of General and Environmental Chemistry, Faculty of Chemistry, Lodz University of Technology, 116 Zeromskiego Street, 90-924 Lodz, Poland. FAU - Safinski, Piotr AU - Safinski P AD - Department of Developmental Neurology and Epileptology, Research Institute of Polish Mother's Memorial Hospital, 93-338 Lodz, Poland. FAU - Przyslo, Lukasz AU - Przyslo L AUID- ORCID: 0000-0003-0209-4103 AD - Department of Developmental Neurology and Epileptology, Research Institute of Polish Mother's Memorial Hospital, 93-338 Lodz, Poland. FAU - Kaluzna-Czaplinska, Joanna AU - Kaluzna-Czaplinska J AUID- ORCID: 0000-0002-5106-4667 AD - Institute of General and Environmental Chemistry, Faculty of Chemistry, Lodz University of Technology, 116 Zeromskiego Street, 90-924 Lodz, Poland. LA - eng PT - Journal Article DEP - 20260717 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Amino Acids) SB - IM MH - Humans MH - *Diet, Ketogenic MH - *Amino Acids/metabolism MH - *Drug Resistant Epilepsy/diet therapy/blood/metabolism MH - Female MH - Child MH - Male MH - *Metabolomics/methods MH - Gas Chromatography-Mass Spectrometry MH - Child, Preschool MH - *Energy Metabolism MH - *Metabolome MH - Adolescent PMC - PMC13415213 OTO - NOTNLM OT - drug-resistant epilepsy OT - gas chromatography-mass spectrometry OT - ketogenic diet OT - plasma metabolome COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/17 CRDT- 2026/07/28 01:18 PHST- 2026/05/18 00:00 [received] PHST- 2026/07/14 00:00 [revised] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - nu18142347 [pii] AID - nutrients-18-02347 [pii] AID - 10.3390/nu18142347 [doi] PST - epublish SO - Nutrients. 2026 Jul 17;18(14):2347. doi: 10.3390/nu18142347. PMID- 42514408 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260831 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 16 TI - Validation of a Nutrition Screening Tool in Critically Ill Children. LID - 10.3390/nu18142340 [doi] LID - 2340 AB - Background/Objectives: Malnutrition is prevalent among patients in the pediatric intensive care unit (PICU) and has been shown to worsen in some patients during the PICU stay. In critically ill children, malnutrition is associated with longer PICU length of stay and increased mortality. Several tools have been developed and validated to screen for nutritional status in children, but none were specifically designed for critically ill children. Our study aims to fill this gap. The goal of this study was to refine and validate a novel PICU nutrition screening tool in a diverse population of critically ill children from six PICUs across the United States. Methods: Subjects underwent the nutrition screen and a Subjective Global Nutritional Assessment (SGNA). We used chi-square tests and Mann-Whitney tests to compare elements of the nutrition screen to the SGNA to identify those elements most associated with malnutrition. We used stepwise logistic regression to determine the best fitting model for a malnutrition screening tool. We proposed a scoring system using the factors identified in the best fitting model to define a positive screen. Results: We enrolled 732 subjects at six PICUs. Of these, 131 subjects (17.9%) were malnourished per the SGNA. Children with and without malnutrition did not differ with respect to age, sex, or race. The likelihood of malnutrition increased as weight-for-age percentile decreased (p < 0.001). We found that the best fitting model of a malnutrition screening tool for critically ill children included weight-for-age percentile, cancer, feeding less, parent perception of growth as poor, and being significantly underweight. We defined a positive screen that should prompt referral to a dietitian. Conclusions: We have developed a nutrition screening tool for critically ill children. FAU - Burneske, Anna AU - Burneske A AUID- ORCID: 0009-0000-9618-266X AD - Division of Critical Care, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. FAU - Ellenbecker, Collin AU - Ellenbecker C AD - Division of Critical Care, Department of Pediatrics, University of Wisconsin, Madison, WI 53792, USA. FAU - Kuhn, Evelyn AU - Kuhn E AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. FAU - Swoveland, Jacob AU - Swoveland J AUID- ORCID: 0009-0006-8074-7842 AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. FAU - Oelstrom, Matt AU - Oelstrom M AD - Marshfield Clinic, Marshfield, WI 54449, USA. FAU - Hagen, Scott AU - Hagen S AD - Division of Critical Care, Department of Pediatrics, University of Wisconsin, Madison, WI 53792, USA. FAU - Mandli, Sarah AU - Mandli S AUID- ORCID: 0000-0001-8913-4328 AD - Division of Critical Care, Department of Pediatrics, University of Wisconsin, Madison, WI 53792, USA. FAU - Sears, Lynne AU - Sears L AD - Division of Critical Care, Department of Pediatrics, University of Wisconsin, Madison, WI 53792, USA. FAU - Peterson, Jennifer AU - Peterson J AD - Gundersen Health Systems Hospitals and Clinics, La Crosse, WI 54601, USA. FAU - Pringle, Charlene P AU - Pringle CP AUID- ORCID: 0000-0003-3345-7827 AD - Division of Critical Care, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA. FAU - Sheridan, Kelly AU - Sheridan K AD - Division of Critical Care, Department of Pediatrics, University of Florida, Gainesville, FL 32610, USA. FAU - Foxe, Megan AU - Foxe M AD - Division of Critical Care, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA. FAU - Hebron, Abigail AU - Hebron A AD - Division of Critical Care, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA. FAU - Zivick, Elizabeth AU - Zivick E AUID- ORCID: 0000-0001-9916-7211 AD - Division of Critical Care, Department of Pediatrics, Medical University of South Carolina, Charleston, SC 29425, USA. FAU - Fabus, Nicole AU - Fabus N AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. FAU - Heisler, Rebecca AU - Heisler R AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. FAU - Froh, Melissa AU - Froh M AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. FAU - Shad, Sadaf AU - Shad S AD - Division of Critical Care, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. FAU - Mikhailov, Theresa AU - Mikhailov T AUID- ORCID: 0000-0003-1744-9739 AD - Division of Critical Care, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, WI 53226, USA. AD - Children's Hospital of Wisconsin, Milwaukee, WI 53226, USA. LA - eng PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20260716 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Critical Illness MH - Female MH - Child, Preschool MH - *Nutrition Assessment MH - Male MH - Intensive Care Units, Pediatric MH - *Nutritional Status MH - Child MH - Infant MH - *Malnutrition/diagnosis MH - Logistic Models MH - United States MH - *Mass Screening/methods MH - *Child Nutrition Disorders/diagnosis MH - Reproducibility of Results MH - Adolescent PMC - PMC13416380 OTO - NOTNLM OT - clinical nutrition OT - critically ill child OT - enteral nutrition OT - malnutrition OT - nutrition screening tool OT - nutritional support OT - pediatric nutrition COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/16 CRDT- 2026/07/28 01:18 PHST- 2026/05/04 00:00 [received] PHST- 2026/06/29 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - nu18142340 [pii] AID - nutrients-18-02340 [pii] AID - 10.3390/nu18142340 [doi] PST - epublish SO - Nutrients. 2026 Jul 16;18(14):2340. doi: 10.3390/nu18142340. PMID- 42514398 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 16 TI - Anaemia Prevention Among Adolescent Girls in Lodhran, Punjab, Pakistan: A School-Based Weekly Iron-Folic Acid Supplementation Pilot Program. LID - 10.3390/nu18142329 [doi] LID - 2329 AB - BACKGROUND/OBJECTIVES: Pakistan has one of the highest burdens of adolescent anaemia in South Asia. A Weekly Iron-Folic Acid Supplementation (WIFAS) program for school-going adolescent girls aged 10-19 years was piloted in the Lodhran District, Punjab, Pakistan. METHODS: A quantitative cross-sectional study was conducted among 750 girls, selected by multi-stage random cluster sampling from 50 public schools across Lodhran; qualitative data were generated through in-depth interviews and focus group discussions with 327 stakeholders. Quantitative data were analyzed using a chi-square test in SPSS. Qualitative data were analyzed in NVIVO using thematic analysis based on the Socio-Ecological Model, enabling environment and institutional systems, community engagement, behavior change and adolescent empowerment and agency. Coding was guided by overarching research questions of acceptability, feasibility and impact. Cases of anaemia averted were estimated using program data and outcome modeling. Qualitative findings were triangulated with quantitative results. RESULTS: The program reached 30,506 girls and was estimated to have averted 5659 cases of anaemia. WIFAS coverage increased from 0% to 100%, with a high level of adherence (80%). Knowledge about anaemia, its signs/symptoms and preventative measures increased significantly at endline. Dietary practices showed positive changes, with significant increase in girls never skipping a meal. Stakeholders attributed success to the creation of an enabling environment through institutional alignment and multisectoral collaboration, culturally adapted, adolescent-friendly materials, and robust community mobilization that proactively addressed socio-cultural barriers. CONCLUSIONS: The school-based WIFAS program for reducing anaemia among adolescent girls was feasible and acceptable in a context where few nutrition services are available to girls. FAU - Kureishy, Sumra AU - Kureishy S AUID- ORCID: 0009-0004-6925-804X AD - Nutrition International, Ottawa, ON K2P 2K3, Canada. FAU - Qureshi, Asim Shahzad AU - Qureshi AS AUID- ORCID: 0009-0002-0425-4107 AD - Nutrition International, Islamabad 44000, Pakistan. FAU - Ambreen, Rakhshinda AU - Ambreen R AUID- ORCID: 0000-0003-2310-1093 AD - Nutrition International, Islamabad 44000, Pakistan. FAU - Raza, Shabina AU - Raza S AUID- ORCID: 0009-0004-4230-8529 AD - Nutrition International, Islamabad 44000, Pakistan. FAU - Roche, Marion L AU - Roche ML AUID- ORCID: 0000-0002-7834-5581 AD - Nutrition International, Ottawa, ON K2P 2K3, Canada. LA - eng GR - ISG1/Global Affairs Canada/ PT - Journal Article DEP - 20260716 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 935E97BOY8 (Folic Acid) RN - E1UOL152H7 (Iron) SB - IM MH - Humans MH - Female MH - Pakistan/epidemiology MH - Adolescent MH - *Dietary Supplements MH - Pilot Projects MH - Child MH - Cross-Sectional Studies MH - *Folic Acid/administration & dosage MH - *Iron/administration & dosage MH - Health Knowledge, Attitudes, Practice MH - *School Health Services MH - Young Adult MH - *Anemia/prevention & control/epidemiology MH - Schools MH - *Anemia, Iron-Deficiency/prevention & control/epidemiology PMC - PMC13415225 OTO - NOTNLM OT - adolescent girls OT - anaemia OT - school-based supplementation COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/16 CRDT- 2026/07/28 01:18 PHST- 2026/04/22 00:00 [received] PHST- 2026/07/07 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - nu18142329 [pii] AID - nutrients-18-02329 [pii] AID - 10.3390/nu18142329 [doi] PST - epublish SO - Nutrients. 2026 Jul 16;18(14):2329. doi: 10.3390/nu18142329. PMID- 42514367 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 14 TI - Diagnostic Utility of Simple Inflammatory Markers for Metabolic Dysfunction-Associated Steatotic Liver Disease and Metabolic Syndrome in Children with Obesity. LID - 10.3390/nu18142298 [doi] LID - 2298 AB - Background: Obesity markedly increases the risk of metabolic syndrome (MetS) and metabolic dysfunction-associated steatotic liver disease (MASLD), both of which are characterized by persistent low-grade inflammation. This study aimed to evaluate the diagnostic utility of complete blood count-derived inflammatory markers, including neutrophil-percentage-to-albumin ratio (NPAR), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR), for MASLD and MetS in children with obesity. Methods: Children with obesity aged 7-18 years were prospectively enrolled and underwent anthropometric assessment, laboratory evaluation, and transient elastography with controlled attenuation parameter (CAP) measurement. Participants were classified into MASLD (CAP >/= 250 dB/m) and non-MASLD groups. Children aged >/=10 years were additionally evaluated for MetS according to the International Diabetes Federation criteria. Logistic regression analyses assessed associations between inflammatory markers and MASLD or MetS, while receiver operating characteristic (ROC) analysis evaluated their diagnostic performance. Results: Children with MASLD had significantly higher NLR and lower LMR values than those without MASLD. Higher NLR (OR = 1.946, 95% CI: 1.092-3.467, p = 0.024) and lower LMR (OR = 0.722, 95% CI: 0.539-0.966, p = 0.028) were associated with MASLD, whereas NPAR and PLR were not. After adjustment for age, sex, body mass index and C-reactive protein, both NLR and LMR remained independently associated with MASLD. ROC analysis showed moderate diagnostic performance (AUC = 0.629 for NLR and 0.616 for LMR). None of the evaluated markers were associated with MetS. Conclusions: NLR and LMR were independently associated with MASLD in children with obesity and may represent complementary screening biomarkers for pediatric MASLD. However, given the cross-sectional design and moderate diagnostic performance observed in this study, prospective multicenter studies are needed to validate these findings before clinical implementation. FAU - Zajkowska-Sierpniak, Aleksandra M AU - Zajkowska-Sierpniak AM AUID- ORCID: 0009-0008-0526-3092 AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Kwiatek-Sredzinska, Kamila A AU - Kwiatek-Sredzinska KA AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Kowalczuk-Kryston, Monika AU - Kowalczuk-Kryston M AUID- ORCID: 0000-0003-0717-9165 AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Lebensztejn, Anna AU - Lebensztejn A AD - Students' Scientific Association Affiliated with the Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Bobrus-Chociej, Anna AU - Bobrus-Chociej A AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Flisiak-Jackiewicz, Marta AU - Flisiak-Jackiewicz M AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Cudowska, Beata AU - Cudowska B AUID- ORCID: 0000-0002-8062-5865 AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. FAU - Lebensztejn, Dariusz M AU - Lebensztejn DM AD - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition, Allergology and Pulmonology, Medical University of Bialystok, Waszyngtona Street 17, 15-274 Bialystok, Poland. LA - eng GR - Grant No: B.SUB.26.423./Medical University of Bialystok/ PT - Journal Article DEP - 20260714 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Child MH - *Metabolic Syndrome/diagnosis/blood/etiology/complications MH - Male MH - Female MH - Biomarkers/blood MH - Adolescent MH - *Inflammation/blood MH - Prospective Studies MH - *Pediatric Obesity/complications/blood MH - ROC Curve MH - *Non-alcoholic Fatty Liver Disease/diagnosis/blood MH - *Fatty Liver/diagnosis/blood/etiology MH - Neutrophils MH - Lymphocytes PMC - PMC13414763 OTO - NOTNLM OT - children OT - inflammatory markers OT - metabolic dysfunction-associated steatotic liver disease OT - metabolic syndrome OT - obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/14 CRDT- 2026/07/28 01:18 PHST- 2026/06/12 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - nu18142298 [pii] AID - nutrients-18-02298 [pii] AID - 10.3390/nu18142298 [doi] PST - epublish SO - Nutrients. 2026 Jul 14;18(14):2298. doi: 10.3390/nu18142298. PMID- 42514362 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 13 TI - The EduNutriCRC Questionnaire: A Pilot Knowledge-Attitudes-Practices Study on Nutritional Prevention of Colorectal Cancer in Romanian Adults. LID - 10.3390/nu18142293 [doi] LID - 2293 AB - BACKGROUND/OBJECTIVES: Colorectal cancer (CRC) disproportionately affects Romania, where mortality exceeds the EU average and screening uptake remains low. Diet is among the most modifiable CRC risk factors, yet no validated instrument for assessing nutritional knowledge, attitudes, and practices (KAP) related to CRC prevention exists for the Romanian population. We developed and pilot-tested the EduNutriCRC questionnaire and characterised the corresponding nutritional KAP profile of Romanian adults. METHODS: In a cross-sectional pilot study (April-May 2026), a convenience sample of 301 Romanian adults aged 18-74 years completed the 51-item self-administered questionnaire. The instrument was evaluated for internal consistency and dimensional structure (exploratory factor analysis), with non-parametric tests used for group comparisons. RESULTS: The composite knowledge score (C1-C9; maximum 9) was 6.12 +/- 2.25 with wide item-level variation. Internal consistency was acceptable, and the Attitudes subscale resolved into two factors (Motivation & Self-Efficacy and Perceived Barriers). Screening engagement was critically low (92.4% never tested; 81.7% unaware of the national programme). Although 64.1% expressed willingness to change their diet, 46.2% reported consuming processed meat at least weekly. Motivation & Self-Efficacy, but not the knowledge score, was inversely correlated with risk-food consumption (rho = -0.39, p < 0.001). CONCLUSIONS: EduNutriCRC demonstrated acceptable psychometric properties at the pilot stage. The study identified prevalent nutritional misconceptions, a marked knowledge-behaviour gap, low screening awareness, and a structural mismatch between information sources used and those trusted. Attitudes and self-efficacy, rather than factual knowledge, were the more proximal correlates of dietary behaviour, supporting the development of self-efficacy-focused, culturally adapted educational interventions for CRC prevention in Romania, with EduNutriCRC serving as a baseline and monitoring instrument. FAU - Neamtu, Andreea-Adriana AU - Neamtu AA AUID- ORCID: 0000-0002-5219-5466 AD - Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. AD - Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. AD - Department of Pathology, Clinical County Emergency Hospital of Arad, Andrenyi Karoly Str., No. 2-4, 310037 Arad, Romania. AD - Department of Pathology, "Pius Brinzeu" Clinical County Emergency Hospital Timisoara, Liviu Rebreanu Boulevard, No. 156, 300723 Timisoara, Romania. FAU - Anton, Alina AU - Anton A AUID- ORCID: 0000-0002-3818-5261 AD - Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. AD - Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Maghiar, Laura AU - Maghiar L AUID- ORCID: 0000-0001-8901-8271 AD - Department of Psycho-Neurosciences and Rehabilitation, Faculty of Medicine and Pharmacy, University of Oradea, Universitatii Str., No. 1, 410087 Oradea, Romania. AD - Department of Dermatovenerology, Clinical County Emergency Hospital Bihor, 410169 Oradea, Romania. FAU - Iftode, Andrada AU - Iftode A AD - Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. AD - Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Capraru, Anca-Maria AU - Capraru AM AUID- ORCID: 0009-0001-5908-0231 AD - Doctoral School, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. AD - Department of Pharmacy, Poiana Mare Psychiatry Hospital, Garii Str., No. 40, 207470 Poiana Mare, Romania. FAU - Dumitrescu, Cristina AU - Dumitrescu C AD - Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. AD - Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Kis, Andreea-Mihaela AU - Kis AM AUID- ORCID: 0009-0004-4581-8487 AD - Department of Management and Communication in Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Popovici, Ramona Amina AU - Popovici RA AUID- ORCID: 0000-0002-3852-9060 AD - Department of Management and Communication in Dental Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Dehelean, Cristina-Adriana AU - Dehelean CA AD - Department of Toxicology, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. AD - Research Centre for Pharmaco-Toxicological Evaluation, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square, No. 2, 300041 Timisoara, Romania. FAU - Maghiar, Teodor-Andrei AU - Maghiar TA AD - Department of Surgery, Faculty of Medicine and Pharmacy, University of Oradea, Universitatii Str., No. 1, 410087 Oradea, Romania. AD - Department of Surgery, Pelican Hospital, Corneliu Coposu Str., No. 2, 410450 Oradea, Romania. LA - eng PT - Journal Article DEP - 20260713 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adult MH - Middle Aged MH - Romania MH - *Colorectal Neoplasms/prevention & control MH - *Health Knowledge, Attitudes, Practice MH - Female MH - Male MH - Pilot Projects MH - Aged MH - Surveys and Questionnaires MH - Cross-Sectional Studies MH - Adolescent MH - Young Adult MH - *Diet MH - Risk Factors MH - Nutritional Status MH - Feeding Behavior PMC - PMC13414599 OTO - NOTNLM OT - cancer prevention OT - colorectal cancer OT - dietary risk factors OT - health literacy OT - knowledge-attitudes-practices (KAP) OT - nutrition education OT - nutritional prevention OT - pilot validation study OT - questionnaire COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/13 CRDT- 2026/07/28 01:18 PHST- 2026/05/26 00:00 [received] PHST- 2026/06/26 00:00 [revised] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - nu18142293 [pii] AID - nutrients-18-02293 [pii] AID - 10.3390/nu18142293 [doi] PST - epublish SO - Nutrients. 2026 Jul 13;18(14):2293. doi: 10.3390/nu18142293. PMID- 42514356 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 13 TI - Understanding the Gap Between Nutritional Knowledge and Dietary Behavior Among Adolescents with Different BMI Statuses. LID - 10.3390/nu18142287 [doi] LID - 2287 AB - Background/Objectives: The aim of this study was to examine the discrepancy between nutrition-related knowledge (NRK) and nutrition-related practice (NRP) among 1440 Polish school-aged students (10-18 years), according to BMI status, and to identify factors associated with this discrepancy. Methods: This cross-sectional study was conducted via the CAWI method using an author-developed, non-validated questionnaire. Questions assessing NRK and NRP were thematically aligned and referred to the recommendations of the Polish Healthy Eating and Lifestyle Pyramid for Children and Adolescents (aged 4-18 years). Results: Students with excess weight scored significantly lower in nutritional knowledge (NRK: 46%) and practices (NRP: 30%) than those with underweight or normal weight (NRK: 52-53%, NRP: 33-34%). Higher NRK was associated with older age, female sex, larger urban residence (for students with overweight and obesity), and higher maternal/legal guardian education level (for students with normal/underweight body weight). Better NRP was associated with higher NRK and higher physical activity, while rural or small-town living was positively associated with healthier dietary practices and maintenance of normal BMI. Conclusions: The present study confirms that nutritional knowledge is a necessary but insufficient condition for shaping appropriate dietary behaviors among adolescents with different BMI statuses; lifestyle factors, practical food-related skills-including self-assessment of knowledge and adherence to dietary recommendations-and the broader environmental context plays a crucial role. These findings highlight the need for targeted nutrition education programs that expand not only knowledge but also practical skills among students. FAU - Wawrzyniak, Agata AU - Wawrzyniak A AUID- ORCID: 0000-0002-8452-0526 AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW-WULS), 02-787 Warsaw, Poland. FAU - Traczyk, Iwona AU - Traczyk I AUID- ORCID: 0000-0001-7413-1212 AD - The Department of Environmental Hazard Prevention, Allergology and Immunology, Faculty of Health Sciences, Medical University of Warsaw, 02-007 Warsaw, Poland. LA - eng PT - Journal Article DEP - 20260713 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Health Knowledge, Attitudes, Practice MH - Male MH - *Body Mass Index MH - Cross-Sectional Studies MH - Child MH - *Feeding Behavior/psychology MH - Poland MH - *Diet, Healthy MH - Surveys and Questionnaires MH - *Adolescent Behavior MH - Nutritional Status MH - Overweight MH - Life Style PMC - PMC13415248 OTO - NOTNLM OT - adolescents OT - body mass index (BMI) OT - food literacy OT - nutrition literacy OT - nutrition-related knowledge (NRK) OT - nutrition-related practice (NRP) OT - physical activity OT - socio-demographic factors COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/13 CRDT- 2026/07/28 01:18 PHST- 2026/06/12 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - nu18142287 [pii] AID - nutrients-18-02287 [pii] AID - 10.3390/nu18142287 [doi] PST - epublish SO - Nutrients. 2026 Jul 13;18(14):2287. doi: 10.3390/nu18142287. PMID- 42514354 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260825 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 13 TI - Non-HDL Cholesterol as a Practical Gatekeeper for Adolescent Dyslipidemia Screening: Implications for Nutrition and Public Health. LID - 10.3390/nu18142285 [doi] LID - 2285 AB - Dyslipidemia in adolescents represents an early and potentially modifiable stage in the lifelong trajectory of cardiovascular disease. However, optimal lipid screening strategies in this age group remain controversial, particularly regarding feasibility, biological relevance, and reliance on family history. Non-high-density lipoprotein cholesterol (non-HDL cholesterol) has emerged as a promising screening marker because it reflects the total burden of atherogenic lipoproteins and can be reliably assessed even without fasting, making it particularly suitable for large-scale pediatric screening settings. A recent nationwide population-based study of Korean adolescents provides robust real-world evidence supporting the utility of non-HDL cholesterol in dyslipidemia screening, across both sexes and independent of familial lipid risk. From a nutritional and public health perspective, non-HDL cholesterol is closely related to dietary habits, postprandial hyperlipidemia, and metabolic stress, and is particularly important in the modern food environment characterized by increased consumption of ultra-processed foods. This Opinion discusses the biological rationale, clinical feasibility, and population-level implications of non-HDL cholesterol-based screening in adolescents. By linking lipid biology with nutrition-focused prevention and lifelong cardiovascular health, non-HDL cholesterol may serve as a practical gatekeeper for early risk identification and upstream intervention. FAU - Nakamura, Kazufumi AU - Nakamura K AUID- ORCID: 0000-0001-8845-3626 AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Okada, Taiji AU - Okada T AUID- ORCID: 0000-0002-8878-3446 AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Watanabe, Nobuhide AU - Watanabe N AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Sato, Hirotomo AU - Sato H AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Kagawa, Yuzo AU - Kagawa Y AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Kawahara, Hiroshi AU - Kawahara H AUID- ORCID: 0000-0002-0615-4129 AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Sakamoto, Takahiro AU - Sakamoto T AUID- ORCID: 0000-0001-8846-1239 AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Yamasaki, Seita AU - Yamasaki S AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Tanabe, Junya AU - Tanabe J AUID- ORCID: 0000-0001-8263-6077 AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Furuta, Madoka AU - Furuta M AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Kawanami, Yuka AU - Kawanami Y AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Miki, Yuko AU - Miki Y AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. FAU - Endo, Akihiro AU - Endo A AUID- ORCID: 0000-0002-7161-5323 AD - Department of Cardiovascular Medicine, Faculty of Medicine, Shimane University, Izumo 693-8501, Japan. LA - eng PT - Journal Article DEP - 20260713 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) RN - 97C5T2UQ7J (Cholesterol) RN - 0 (Cholesterol, HDL) SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - Biomarkers/blood MH - *Cholesterol/blood MH - Cholesterol, HDL/blood MH - *Dyslipidemias/diagnosis/blood MH - *Mass Screening/methods MH - Nutritional Status MH - *Public Health MH - Risk Factors PMC - PMC13414525 OTO - NOTNLM OT - adolescent OT - dyslipidemia OT - non-HDL cholesterol COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/13 CRDT- 2026/07/28 01:18 PHST- 2026/06/16 00:00 [received] PHST- 2026/07/02 00:00 [revised] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:18 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - nu18142285 [pii] AID - nutrients-18-02285 [pii] AID - 10.3390/nu18142285 [doi] PST - epublish SO - Nutrients. 2026 Jul 13;18(14):2285. doi: 10.3390/nu18142285. PMID- 42514328 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 14 DP - 2026 Jul 10 TI - Sub-Optimal Nutritional Knowledge and Dietary Intake in Gaelic Team Sport Athletes: Limited Associations Between Knowledge and Dietary Adequacy. LID - 10.3390/nu18142259 [doi] LID - 2259 AB - Background/Objectives: To assess the nutritional knowledge and dietary intake of Gaelic team sport athletes and investigate any association between nutrition knowledge and dietary intake. Methods: Male/female athletes competing in Gaelic football, hurling and camogie, aged 18-40 years and training/competing at least twice weekly, were recruited. Nutrition knowledge was assessed using the validated Nutrition for Sport Knowledge Questionnaire (NSKQ). Dietary intake was assessed using a 4-day semi-quantitative food diary. Results: In total, 354 players (male n = 215, female n = 139; elite n = 133, sub-elite n = 221) completed the NSKQ; 53.1% had "poor" knowledge (score 0.70), although several scales showed lower reliability estimates. Results: Adolescents diagnosed with eating disorders showed significantly higher levels of problematic eating behaviours (rg = 0.94), exercise fixation (rg = 0.71), exercise commitment (rg = 0.33), withdrawal symptoms (rg = 0.52), exercise for weight control (rg = 0.83), and insight into problems (rg = 0.77) than athletes. In contrast, athletes reported higher levels of exercise for social (rg = 0.74) and health-related reasons (rg = 0.40). Effect sizes ranged from moderate to very large. These findings indicate marked differences in the psychological motives and compulsive characteristics of exercise between adolescents with eating disorders and athletes. Conclusions: This pilot study suggests that adolescents with eating disorders differ from athletes primarily in the psychological characteristics and motives underlying exercise rather than in exercise volume alone. These findings may help inform the assessment of problematic exercise in clinical practice, although they require confirmation in larger, adequately controlled studies. FAU - Jaroch-Lidzbarska, Magdalena AU - Jaroch-Lidzbarska M AUID- ORCID: 0000-0002-5355-8716 AD - Department of Physical Culture, Gdansk University of Physical Education and Sport, Kazimierza Gorskiego 1, 80-336 Gdansk, Poland. FAU - Hryniewicz, Konrad AU - Hryniewicz K AD - Department of Marketing and Quantitative Methods, Faculty of Management and Quality Science, Gdynia Maritime University, Morska 81/87, 81-225 Gdynia, Poland. FAU - Sawicki, Piotr AU - Sawicki P AD - Department of Physical Culture, Gdansk University of Physical Education and Sport, Kazimierza Gorskiego 1, 80-336 Gdansk, Poland. FAU - Wilczynska, Dominika AU - Wilczynska D AD - Faculty of Social and Humanities, WSB Merito University, Grunwaldzka 238A, 80-266 Gdansk, Poland. LA - eng PT - Journal Article DEP - 20260712 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13412378 OTO - NOTNLM OT - adolescents OT - athletes OT - eating disorders OT - obligatory exercise OT - psychiatric patients COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/12 CRDT- 2026/07/28 01:14 PHST- 2026/05/24 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:14 [entrez] PHST- 2026/07/12 00:00 [pmc-release] AID - jcm15145455 [pii] AID - jcm-15-05455 [pii] AID - 10.3390/jcm15145455 [doi] PST - epublish SO - J Clin Med. 2026 Jul 12;15(14):5455. doi: 10.3390/jcm15145455. PMID- 42512745 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 14 DP - 2026 Jul 22 TI - Validation of the Revised Version of the Social Cognitive Theory-Based Scale for Factors Influencing Eating Behavior in Adolescents. LID - 10.3390/healthcare14142229 [doi] LID - 2229 AB - Background/Objectives: Social Cognitive Theory (SCT) constructs are associated with adolescents' eating habits. Validated surveys are needed to assess these constructs (in different populations and languages), considering both personal and socio-environmental factors, including peer influence. Therefore, the objective of this study was to validate the SCT-based Scale for Factors Influencing Eating Behavior in Adolescents (SCT-FIEBA), in Spanish. Methods: The scale was administered to 705 high school students from two schools in the Guadalajara Metropolitan Area, Mexico, with randomized and stratified selection. Two weeks later, 43 participants completed the retest. Construct validity was assessed using exploratory factor analysis (EFA) and confirmatory factor analysis (CFA); internal consistency was assessed using Cronbach's alpha and McDonald's omega; and temporal stability was assessed using the Intraclass Correlation Coefficient (ICC), with 95% confidence intervals (CIs). Additionally, factor patterns influencing eating behavior were identified using hierarchical cluster analysis and discriminant analysis. Results: EFA (n = 353) showed an adequate structure with seven or eight factors (with 34 items). However, CFA (n = 352) showed a better fit with eight factors and 33 items (RMSEA = 0.073, SRMR = 0.083, CFI = 0.91, TLI = 0.90) than the other models. The scale's internal consistency was excellent (Cronbach's alpha = 0.92, CI 0.92-0.93; McDonald's omega = 0.93, CI 0.92-0.93), with all sections scoring from moderate to excellent. The reproducibility indices were good for the whole scale (ICC = 0.70, CI 0.50-0.82) and four sections; the other four presented moderate values. It is recommended to verify reproducibility in a larger sample. Hierarchical cluster analysis yielded better results with four patterns influencing eating behavior based on SCT, and the discriminant analysis results were satisfactory (Wilks' lambda = 0.108; 87% of cases correctly classified). Conclusions: The SCT-FIEBA demonstrated validity and reliability for assessing SCT constructs applied to eating behavior among high school adolescents in a Mexican population, as well as for identifying four distinct psychosocial patterns that influence eating behavior. FAU - Flores-Vazquez, Ana Silvia AU - Flores-Vazquez AS AUID- ORCID: 0000-0002-2268-9959 AD - Departamento de Alimentacion y Nutricion, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Independencia, Guadalajara 44340, Jalisco, Mexico. FAU - Rodriguez-Rocha, Norma Patricia AU - Rodriguez-Rocha NP AUID- ORCID: 0000-0001-5800-3130 AD - Departamento de Alimentacion y Nutricion, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Independencia, Guadalajara 44340, Jalisco, Mexico. AD - Instituto Regional de Investigacion en Salud Publica, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Independencia, Guadalajara 44340, Jalisco, Mexico. FAU - Franco-Paredes, Karina AU - Franco-Paredes K AUID- ORCID: 0000-0002-5899-3071 AD - Departamento de Promocion, Preservacion y Desarrollo de la Salud, Centro Universitario del Sur, Universidad de Guadalajara, Avenida Enrique Arreola Silva 883, Centro, Ciudad Guzman 49000, Jalisco, Mexico. FAU - Macedo-Ojeda, Gabriela AU - Macedo-Ojeda G AUID- ORCID: 0000-0002-3815-2160 AD - Departamento de Alimentacion y Nutricion, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Independencia, Guadalajara 44340, Jalisco, Mexico. AD - Instituto de Investigacion en Ciencias Biomedicas, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Sierra Mojada 950, Independencia, Guadalajara 44340, Jalisco, Mexico. LA - eng GR - 661992/National Council for Humanities, Sciences, and Technologies (CONAHCYT)/ PT - Journal Article DEP - 20260722 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13411829 OTO - NOTNLM OT - adolescents OT - nutrition OT - reliability OT - scale OT - social cognitive theory OT - validity COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/22 CRDT- 2026/07/28 01:12 PHST- 2026/05/14 00:00 [received] PHST- 2026/07/16 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:12 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - healthcare14142229 [pii] AID - healthcare-14-02229 [pii] AID - 10.3390/healthcare14142229 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jul 22;14(14):2229. doi: 10.3390/healthcare14142229. PMID- 42512730 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 14 DP - 2026 Jul 21 TI - Caregivers' Attitudes Toward Baby-Led Weaning: Development and Psychometric Validation of the BLW-CAS. LID - 10.3390/healthcare14142214 [doi] LID - 2214 AB - Background/Objectives: Baby-Led Weaning (BLW) is an increasingly adopted complementary feeding approach in which infants self-feed family foods rather than being spoon-fed purees. Caregivers' attitudes play a central role in its adoption and implementation, yet no validated instrument has been specifically designed to assess caregivers' attitudes toward BLW. This study aimed to develop and psychometrically validate the BLW Caregiver Attitudes Scale (BLW-CAS). Methods: A methodological psychometric study was conducted in two phases. Scale development involved a literature review, expert panel evaluation, and cognitive pretesting with caregivers. Psychometric validation was conducted among 256 caregivers, while temporal stability was assessed in an independent test-retest sample of 92 caregivers. Content validity, internal consistency, temporal stability, construct validity, and convergent validity were examined using established psychometric methods. Results: The final 16-item BLW-CAS comprised three dimensions: Predisposition, Self-efficacy, and Practical Skills. The revised scale achieved an S-CVI/Ave of 0.93. The three-factor exploratory solution accounted for 67.46% of the total item variance. The three-factor CFA model showed good overall fit (CFI = 0.995; TLI = 0.994; RMSEA = 0.052; SRMR = 0.066). Internal consistency was acceptable to excellent across subscales (alpha = 0.757-0.913; omega = 0.807-0.953), and test-retest reliability was good (ICC = 0.832). Positive small-to-moderate correlations with general self-efficacy (r = 0.298) and decision satisfaction (r = 0.350) supported convergent validity. Conclusions: The Spanish BLW-CAS is a concise, multidimensional instrument with promising psychometric properties for assessing caregivers' attitudes toward BLW, supporting future research and the evaluation of interventions related to complementary feeding practices. FAU - Marquez-Diaz, Rita Rocio AU - Marquez-Diaz RR AUID- ORCID: 0000-0003-4842-3208 AD - Hospital Universitario Virgen de las Nieves, 18014 Granada, Spain. FAU - Ruiz-Fernandez, Maria Dolores AU - Ruiz-Fernandez MD AUID- ORCID: 0000-0002-6454-4723 AD - Department of Nursing Science, Physiotherapy and Medicine, University of Almeria, 04120 Almeria, Spain. AD - Facultad de Ciencias de la Salud, Universidad Autonoma de Chile, Temuco 4780000, Chile. FAU - Ventura-Miranda, Maria Isabel AU - Ventura-Miranda MI AUID- ORCID: 0000-0001-8949-5772 AD - Department of Nursing Science, Physiotherapy and Medicine, University of Almeria, 04120 Almeria, Spain. FAU - Fernandez-Medina, Isabel Maria AU - Fernandez-Medina IM AUID- ORCID: 0000-0003-0805-1542 AD - Department of Nursing Science, Physiotherapy and Medicine, University of Almeria, 04120 Almeria, Spain. LA - eng PT - Journal Article DEP - 20260721 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13409823 OTO - NOTNLM OT - attitudes OT - baby-led weaning OT - caregivers OT - complementary feeding OT - psychometrics OT - scale development COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:36 MHDA- 2026/07/28 06:37 PMCR- 2026/07/21 CRDT- 2026/07/28 01:12 PHST- 2026/05/08 00:00 [received] PHST- 2026/07/08 00:00 [revised] PHST- 2026/07/17 00:00 [accepted] PHST- 2026/07/28 06:37 [medline] PHST- 2026/07/28 06:36 [pubmed] PHST- 2026/07/28 01:12 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - healthcare14142214 [pii] AID - healthcare-14-02214 [pii] AID - 10.3390/healthcare14142214 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jul 21;14(14):2214. doi: 10.3390/healthcare14142214. PMID- 42512699 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 14 DP - 2026 Jul 20 TI - Exploring the Association Between Psychological Inflexibility, Experiential Avoidance and Sleep-Related Problems Among Adolescents: The EHDLA Study. LID - 10.3390/healthcare14142183 [doi] LID - 2183 AB - Background: Adolescence is a sensitive period during which sleep undergoes substantial change, increasing vulnerability to sleep disturbances and their health consequences. Psychological inflexibility (PI) and experiential avoidance (EA), operationalized through the Acceptance and Action Questionnaire-II (AAQ-II), have been associated with poorer sleep among adults; however, evidence in adolescents remains scarce. This study examined the association between PI, EA, and sleep-related problems in a representative sample of Spanish adolescents. Methods: A cross-sectional analysis was conducted using data from 623 adolescents (aged 12-17 years; 56.7% girls) from the Eating Healthy and Daily Life Activities (EHDLA) study, conducted in the Valle de Ricote (Murcia, Spain) during 2021-2022. PI and EA were assessed with the Spanish-validated AAQ-II; sleep-related problems were screened using the BEARS (B = Bedtime problems, E = Excessive daytime sleepiness, A = Awakenings during the night, R = Regularity and duration of sleep, S = Snoring) questionnaire across five domains. Generalized linear models were adjusted for sex, age, socioeconomic status, physical activity, sedentary behavior, body mass index (BMI) z-score, energy intake, and sleep duration. Results: Higher AAQ-II scores were significantly associated with increased probabilities of bedtime problems (+0.9% per point; 95% confidence interval [CI]: 0.6-1.1%), excessive daytime sleepiness (+1.0%; 95% CI: 0.7-1.2%), nocturnal awakenings (+0.7%; 95% CI: 0.5-1.0%), and problems with sleep regularity and duration (+0.8%; 95% CI: 0.5-1.1%). Each additional AAQ-II point increased the probability of reporting any sleep-related problem by 1.2% (95% CI: 0.9-1.5%; p < 0.001). Corresponding adjusted odds ratios ranged from 1.04 to 1.06 per point. No significant association was found for snoring. Conclusions: In this cross-sectional study, psychological inflexibility and experiential avoidance were positively associated with several sleep-related problems among adolescents. Longitudinal and intervention studies are warranted before causal or clinical recommendations can be made. FAU - Zalamea-Delgado, Maria Paula AU - Zalamea-Delgado MP AUID- ORCID: 0009-0004-2607-2907 AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Guayaquil 0901952, Ecuador. FAU - Jimenez-Lopez, Estela AU - Jimenez-Lopez E AUID- ORCID: 0000-0001-8553-7701 AD - Health and Social Research Center, Universidad de Castilla-La Mancha, 16002 Cuenca, Spain. AD - Centro de Investigacion Biomedica en Red de Salud Mental, Instituto de Salud Carlos III, 28029 Madrid, Spain. FAU - Mesas, Arthur Eumann AU - Mesas AE AUID- ORCID: 0000-0002-0088-8607 AD - Health and Social Research Center, Universidad de Castilla-La Mancha, 16002 Cuenca, Spain. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AUID- ORCID: 0000-0002-9311-6576 AD - Faculty Education and Social Sciences, Universidad Andres Bello, Vina del Mar 2520000, Chile. FAU - Gutierrez-Espinoza, Hector AU - Gutierrez-Espinoza H AUID- ORCID: 0000-0002-4650-3426 AD - Faculty of Education, Universidad Autonoma de Chile, Santiago 7500138, Chile. FAU - Olivares-Arancibia, Jorge AU - Olivares-Arancibia J AUID- ORCID: 0000-0002-7186-3941 AD - AFySE Group, Research in Physical Activity and School Health, School of Physical Education, Faculty of Education, Universidad de las Americas, Santiago 8320000, Chile. FAU - Ezzatvar, Yasmin AU - Ezzatvar Y AUID- ORCID: 0000-0002-9691-5998 AD - Lifestyle Factors with Impact on Ageing and Overall Health (LAH) Research Group, Department of Nursing, University of Valencia, 46010 Valencia, Spain. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno 5290000, Chile. FAU - Stubbs, Brendon AU - Stubbs B AUID- ORCID: 0000-0001-7387-3791 AD - Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London WC2R 2LS, UK. AD - Center for Sport Science and University Sports, University of Vienna, 1010 Wien, Austria. FAU - Smith, Lee AU - Smith L AUID- ORCID: 0000-0002-5340-9833 AD - Centre for Health Performance and Wellbeing, Anglia Ruskin University, Cambridge CB1 1PT, UK. AD - Department of Public Health, Faculty of Medicine, Biruni University, Istanbul 34015, Turkey. FAU - Ridgell, Lucille AU - Ridgell L AUID- ORCID: 0009-0001-5956-5925 AD - Carver University, Orlando, FL 32804, USA. FAU - Mino, Camila AU - Mino C AUID- ORCID: 0000-0002-9444-8564 AD - Universidad Internacional para el Desarrollo (UNINDE), Extremadura, 06080 Badajoz, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Guayaquil 0901952, Ecuador. AD - Department of Sport Sciences, Faculty of Sport and Health Sciences, Fit Generation Research Institute, AD500 Andorra la Vella, Andorra. LA - eng PT - Journal Article DEP - 20260720 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13410315 OTO - NOTNLM OT - adolescent OT - avoidance behaviors OT - cross-sectional studies OT - experiential avoidance OT - psychological inflexibility OT - psychological resiliency OT - sleep disturbances COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/20 CRDT- 2026/07/28 01:12 PHST- 2026/05/29 00:00 [received] PHST- 2026/07/02 00:00 [revised] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:12 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - healthcare14142183 [pii] AID - healthcare-14-02183 [pii] AID - 10.3390/healthcare14142183 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jul 20;14(14):2183. doi: 10.3390/healthcare14142183. PMID- 42512211 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20261014 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 7 DP - 2026 Jul 15 TI - Strategies to Promote the Integration of Fermented Foods in the Daily Diet to Improve Children's Health in Capricorn District, South Africa: A Mixed Method Study Protocol. LID - 10.3390/ijerph23070907 [doi] LID - 907 AB - Child health remains a critical global public health concern, with malnutrition, diarrhea and pneumonia consistently driving high morbidity and mortality rates among children under the age of five. The World Health Organization (WHO) estimates that malnutrition accounts for approximately 3.1 million child deaths annually. In South Africa, persistent challenges such as stunting, micronutrient deficiencies, and food insecurity remain prevalent, particularly in rural communities, despite the existing interventions. Fermented foods present a culturally acceptable, affordable, and sustainable strategy to address malnutrition and improve gut health, potentially reducing stunting and diarrheal diseases. This article presents a protocol for a future four-phase mixed-method study that will be conducted to develop and validate strategies to promote the integration of fermented foods into children's daily diets. The researchers will employ an exploratory sequential mixed methods design in three phases for the purpose of the envisaged study: bibliometric analysis, qualitative inquiry through in-depth interviews with caregivers and nurses, and a quantitative survey developed from qualitative findings. By combining qualitative and quantitative data, the study seeks to generate evidence-based, context-specific strategies for policy and programmatic integration. The anticipated outcome is a framework to support the inclusion of fermented foods in child nutrition programs to ensure the improved child health and progress toward the United Nations Sustainable Development Goals (UN SDGs). FAU - Malema, Masilo Isaac AU - Malema MI AUID- ORCID: 0009-0002-3138-656X AD - Department of Public Health, Sefako Makgatho Health Sciences University, 1 Molotlegi Street, Ga-Rankuwa, Pretoria 0208, South Africa. AD - Quality Management Directorate, Walter Sisulu University, Komani Campus, No. 280 Shepstone Road, East London 5200, South Africa. FAU - Matlala, Sogo France AU - Matlala SF AUID- ORCID: 0000-0002-2291-6779 AD - Department of Public Health, Sefako Makgatho Health Sciences University, 1 Molotlegi Street, Ga-Rankuwa, Pretoria 0208, South Africa. FAU - Chelule, Paul Kiprono AU - Chelule PK AUID- ORCID: 0000-0002-3477-3242 AD - Department of Public Health, Sefako Makgatho Health Sciences University, 1 Molotlegi Street, Ga-Rankuwa, Pretoria 0208, South Africa. LA - eng PT - Journal Article DEP - 20260715 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - South Africa MH - *Fermented Foods MH - Child, Preschool MH - *Child Health MH - *Diet MH - Infant MH - Research Design PMC - PMC13411124 OTO - NOTNLM OT - child nutrition OT - fermented foods OT - gut health OT - mixed methods research OT - strategy development OT - traditional diets COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/29 18:38 PMCR- 2026/07/15 CRDT- 2026/07/28 01:11 PHST- 2026/03/11 00:00 [received] PHST- 2026/07/02 00:00 [revised] PHST- 2026/07/04 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:11 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - ijerph23070907 [pii] AID - ijerph-23-00907 [pii] AID - 10.3390/ijerph23070907 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 Jul 15;23(7):907. doi: 10.3390/ijerph23070907. PMID- 42512071 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9059 (Print) IS - 2227-9059 (Electronic) IS - 2227-9059 (Linking) VI - 14 IP - 7 DP - 2026 Jul 16 TI - The Limited Diagnostic Utility of Metabolic and Inflammatory Indices in Adolescent Polycystic Ovary Syndrome: A Case-Control Study. LID - 10.3390/biomedicines14071598 [doi] LID - 1598 AB - Background: The aim of this study was to evaluate the clinical and diagnostic utility of metabolic and systemic inflammatory marker indices in adolescent patients with polycystic ovary syndrome (PCOS). Methods: This retrospective case-control study included 63 adolescent girls diagnosed with PCOS, based on the strict presence of both menstrual irregularity and hyperandrogenism, and 63 healthy controls matched for age and body mass index (BMI). Fasting blood glucose (FBG), fasting insulin (FI), and lipid profiles were measured. Metabolic indices, including the Triglyceride-Glucose (TyG) index, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR), and Metabolic Score for Insulin Resistance (METS-IR), as well as systemic inflammatory indices (Systemic Immune-Inflammation Index (SII), Systemic Inflammation Response Index (SIRI), and the Aggregate Index of Systemic Inflammation (AISI)), were calculated. The diagnostic performance of these markers was evaluated using Receiver Operating Characteristic (ROC) curves and binary logistic regression analyses. Results: No statistically significant difference was observed between the PCOS and control groups in terms of age and BMI (p > 0.05). FBG levels (p = 0.001) and the TyG index (p = 0.028) were found to be significantly higher in the PCOS group. However, no significant differences were observed between the groups in terms of other metabolic indices (HOMA-IR, METS-IR) and systemic inflammatory markers (SII, SIRI, AISI). In the ROC analysis, only the TyG index demonstrated statistically significant but weak discriminatory power for PCOS (AUC = 0.614; 95% CI: 0.515-0.712; p = 0.028). Furthermore, binary logistic regression analysis revealed that the TyG index was not an independent predictor of PCOS after adjustment. Conclusions: While early metabolic signals such as elevated FBG and TyG index were detected, the evaluated systemic inflammatory indices did not demonstrate significant differences. However, the weak discriminatory capacity of the TyG index and the failure of other composite indices restrict their clinical utility. Therefore, these biomarkers cannot be recommended as reliable standalone diagnostic tools in adolescent PCOS. FAU - Ustebay, Sefer AU - Ustebay S AUID- ORCID: 0000-0003-1507-5921 AD - Department of Pediatrics, Faculty of Medicine, Bandirma OnYedi Eylul University, 10200 Bandirma, Turkey. FAU - Deniz, Rulin AU - Deniz R AUID- ORCID: 0000-0002-7306-8212 AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Bandirma OnYedi Eylul University, 10200 Bandirma, Turkey. FAU - Tigli, Alihan AU - Tigli A AUID- ORCID: 0000-0002-9404-4869 AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Bandirma OnYedi Eylul University, 10200 Bandirma, Turkey. FAU - Akinci, Guzide Ece AU - Akinci GE AUID- ORCID: 0000-0003-2782-1143 AD - Gynecology and Obstetrics Clinic, Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital, 34785 Istanbul, Turkey. FAU - Uzuner, Muhammet Bora AU - Uzuner MB AUID- ORCID: 0000-0001-6557-3086 AD - Department of Anatomy, Faculty of Medicine, Bandirma OnYedi Eylul University, 10200 Bandirma, Turkey. FAU - Sener, Nazli AU - Sener N AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Bandirma OnYedi Eylul University, 10200 Bandirma, Turkey. FAU - Degirmenci, Yasemin Ercan AU - Degirmenci YE AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Bandirma OnYedi Eylul University, 10200 Bandirma, Turkey. FAU - Ustebay, Dondu Ulker AU - Ustebay DU AD - Department of Pediatric Neurology, Faculty of Medicine, Bandirma OnYedi Eylul University, 10200 Bandirma, Turkey. FAU - Karakoc, Oguzhan AU - Karakoc O AUID- ORCID: 0000-0001-7918-4524 AD - Gynecology and Obstetrics Clinic, Bandirma Training and Research Hospital, 10200 Bandirma, Turkey. FAU - Yardibi, Yasin Selcuk AU - Yardibi YS AUID- ORCID: 0009-0006-8059-3206 AD - Department of Pediatrics, Faculty of Medicine, Bandirma OnYedi Eylul University, 10200 Bandirma, Turkey. FAU - Almak, Deniz AU - Almak D AUID- ORCID: 0000-0001-6744-5299 AD - Bandirma No. 1 Family Health Centre, Balikesir Provincial Health Directorate, 10200 Bandirma, Turkey. FAU - Baykus, Yakup AU - Baykus Y AUID- ORCID: 0000-0001-5730-8477 AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Bandirma OnYedi Eylul University, 10200 Bandirma, Turkey. LA - eng PT - Journal Article DEP - 20260716 PL - Switzerland TA - Biomedicines JT - Biomedicines JID - 101691304 PMC - PMC13406398 OTO - NOTNLM OT - TyG index OT - adolescence OT - biomarkers OT - inflammation OT - insulin resistance OT - polycystic ovary syndrome COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/16 CRDT- 2026/07/28 01:10 PHST- 2026/06/09 00:00 [received] PHST- 2026/06/23 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:10 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - biomedicines14071598 [pii] AID - biomedicines-14-01598 [pii] AID - 10.3390/biomedicines14071598 [doi] PST - epublish SO - Biomedicines. 2026 Jul 16;14(7):1598. doi: 10.3390/biomedicines14071598. PMID- 42510505 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2306-5354 (Print) IS - 2306-5354 (Electronic) IS - 2306-5354 (Linking) VI - 13 IP - 7 DP - 2026 Jul 21 TI - EGT-UNet: Evolutionary Game-Theoretic Adaptive Optimization for Pediatric Panoramic Tooth Segmentation. LID - 10.3390/bioengineering13070840 [doi] LID - 840 AB - The present work proposes EGT-UNet, an innovative loss optimization mechanism based on Evolutionary Game Theory (EGT) aimed at pediatric panoramic tooth segmentations. In the absence of a large set of high-quality images in the current literature, we developed a novel pediatric panoramic image database, including 1269 images from Ordu University Faculty of Dentistry. The dataset includes subjects aged 3-14, where 67% are males and 33% are females. The annotation of all images was done at the pixel level by a professional orthodontist with a two-fold verification process. In order to prevent data leakage, the dataset was split at the subject level into training/validation (85%) and independent test (15%) sets. Data in the training set were divided into folds for five-fold cross-validation. From a structural point of view, EGT-UNet is an improved version of U-Net, equipped with the following modules: Squeeze-and-Excitation blocks, Attention Gates, and a dilated convolutional module mimicking Atrous Spatial Pyramid Pooling. The main novelty of the proposed approach involves the application of the dynamic change in loss weights. Specifically, in our work, the fusion of three losses-Dice, Focal Tversky and Boundary-was dynamically tuned via replicator dynamics using task-specific fitness functions. The difference with traditional loss-weighting methods is that in the latter case, fixed weights are applied. To evaluate the effect of each component of the EGT-UNet, we conducted an ablation study of six architectures varying in terms of hybrid loss function and dynamic/static weight tuning. Using the independent test dataset, we observed a similar performance level of all models with Dice scores ~0.93. Our best model, called "EGT Aggressive", achieved Dice = 0.931 +/- 0.044, IoU = 0.873 +/- 0.066, and Boundary Dice = 0.631 +/- 0.064. Importantly, this model demonstrated a statistically significant superiority over the baseline network according to region-related metrics and boundary metrics (Wilcoxon p < 0.05). In computational studies, we revealed an increased model robustness when dealing with highly complex mixed dentition images. FAU - Sahin, Muhammet Emin AU - Sahin ME AD - Queen Mary's Digital Environment Research Institute (DERI), London E11HH, UK. AD - Department of Computer Engineering, Izmir Bakircay University, 35665 Izmir, Turkiye. FAU - Ulutas, Hasan AU - Ulutas H AUID- ORCID: 0000-0003-3922-934X AD - Department of Computer Engineering, Yozgat Bozok University, 66100 Yozgat, Turkiye. FAU - Cosar, Halil I AU - Cosar HI AD - Department of Electrical and Electronics Engineering, Yozgat Bozok University, 66100 Yozgat, Turkiye. FAU - Bicer, Tayyip AU - Bicer T AD - Department of Orthodontics, Faculty of Dentistry, Ordu University, 52200 Ordu, Turkiye. FAU - Gunay, Recep B AU - Gunay RB AUID- ORCID: 0009-0001-8913-9775 AD - Department of Computer Technologies, Yozgat Bozok University, 66700 Yozgat, Turkiye. FAU - Buyuk, Suleyman K AU - Buyuk SK AD - Department of Orthodontics, Faculty of Dentistry, Ordu University, 52200 Ordu, Turkiye. AD - Department of Dental Biomaterials Science, Seoul National University, Seoul 03080, Republic of Korea. LA - eng GR - 124E730/The Scientific and Technological Research Council of Turkiye/ PT - Journal Article DEP - 20260721 PL - Switzerland TA - Bioengineering (Basel) JT - Bioengineering (Basel, Switzerland) JID - 101676056 PMC - PMC13403487 OTO - NOTNLM OT - EGT-UNet OT - deep learning OT - panoramic radiography OT - pediatric tooth segmentation COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/21 CRDT- 2026/07/28 01:03 PHST- 2026/05/01 00:00 [received] PHST- 2026/07/15 00:00 [revised] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:03 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - bioengineering13070840 [pii] AID - bioengineering-13-00840 [pii] AID - 10.3390/bioengineering13070840 [doi] PST - epublish SO - Bioengineering (Basel). 2026 Jul 21;13(7):840. doi: 10.3390/bioengineering13070840. PMID- 42510293 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 7 DP - 2026 Jul 11 TI - Acceptability, Perceived Feasibility and Perceived Impact of an Acceptance and Commitment Therapy-Informed Emotion Regulation Program to Assist Parents in Supporting Their Children's Physical Activity: A Qualitative Proof-of-Concept Study. LID - 10.3390/bs16071172 [doi] LID - 1172 AB - Insufficient physical activity (PA) among children remains a public health concern, and parental support is a consistent correlate of child PA. Existing family-based PA interventions have shown modest effects, suggesting a need to address emotional barriers that interfere with parents' support follow-through. This Phase IIa proof-of-concept study examined the acceptability and perceived feasibility of a remotely delivered Acceptance and Commitment Therapy-informed emotion regulation program for parents of children not meeting PA guidelines, and explored perceived changes in parental support. Twenty-one Canadian parents of children aged 6 to 12 years began three 20 to 30 min parent-only online workshops delivered over three weeks; 15 completed all workshops and 12 completed a semi-structured exit interview. Cross-case thematic analysis generated three themes. Parents described the program as acceptable, accessible, and supportive; reported that strategies were feasible to apply and helped them support PA in more flexible, less perfectionistic, and more values-consistent ways; and identified refinements, including stronger support for sustained engagement, greater interactivity, and child inclusion where appropriate. Findings suggest preliminary promise and support further optimization and mixed-method testing of measurable changes in parental support and child or family PA. FAU - Lee, Alfred S Y AU - Lee ASY AUID- ORCID: 0000-0002-8837-7085 AD - Behavioural Medicine Laboratory, Faculty of Education, School of Exercise Science, Physical and Health Education, University of Victoria, P.O. Box 3010 STN CSC, Victoria, BC V8W 3N4, Canada. FAU - Manankil-Lakusta, Alyssa T K AU - Manankil-Lakusta ATK AD - Behavioural Medicine Laboratory, Faculty of Education, School of Exercise Science, Physical and Health Education, University of Victoria, P.O. Box 3010 STN CSC, Victoria, BC V8W 3N4, Canada. FAU - Rhodes, Ryan E AU - Rhodes RE AD - Behavioural Medicine Laboratory, Faculty of Education, School of Exercise Science, Physical and Health Education, University of Victoria, P.O. Box 3010 STN CSC, Victoria, BC V8W 3N4, Canada. LA - eng PT - Journal Article DEP - 20260711 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13405513 OTO - NOTNLM OT - MVPA OT - acceptance and commitment therapy OT - emotional regulation OT - online workshops OT - parental support COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/11 CRDT- 2026/07/28 01:02 PHST- 2026/05/22 00:00 [received] PHST- 2026/06/24 00:00 [revised] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:02 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - bs16071172 [pii] AID - behavsci-16-01172 [pii] AID - 10.3390/bs16071172 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Jul 11;16(7):1172. doi: 10.3390/bs16071172. PMID- 42510283 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 7 DP - 2026 Jul 10 TI - Effects of a Cognitively Enriched Playful Physical Activity Program on Executive Functions and School Readiness in Preschool Children. LID - 10.3390/bs16071162 [doi] LID - 1162 AB - Executive functions (EFs) are foundational for early learning and school readiness. Interventions that couple motor engagement with explicit cognitive demands may offer an efficient approach to support EFs during preschool years. This exploratory randomized controlled trial examined the preliminary effects of an 8-week Playful Physical Activities (PPA) program on EF and school readiness. Preschool children were randomized to (i) PPA, a structured program integrating executive challenges (response inhibition, working memory, and planning) into movement games, or (ii) an active control receiving the regular physical education curriculum (3 sessions/week, 60 min/session, 8 weeks). Outcomes were assessed before and after the intervention and included Go/No-Go error rate, BVMT-R immediate and delayed recall, RCFT copy score, and school readiness domains (mathematical, linguistic, and social competence). Group x Time effects were tested using mixed ANOVA and summarized with partial eta squared (eta(2)p). Between-group post-test differences were quantified using Hedges' g. PPA was associated with greater pre-to-post improvements relative to control in attentional control/inhibition (Go/No-Go errors: eta(2)p = 0.134; g = -1.78) and visuospatial organization/planning (RCFT copy: eta(2)p = 0.307; g = 1.36). Visuospatial memory outcomes showed very large interaction effects (BVMT-R immediate eta(2)p = 0.937, g = 5.14; delayed eta(2)p = 0.854, g = 4.10), but these values are exploratory and should not be emphasized as the primary evidence for cognitive improvement because the BVMT-R was used as a non-normed raw-score index outside its validated age range in this preschool sample. School readiness indicators showed favorable changes across mathematical, linguistic, and social competence (eta(2)p = 0.514, 0.385, and 0.337; g = 1.95, 2.05, and 1.31, respectively). Overall, these preliminary findings suggest that cognitively enriched movement may support EF-related performance and school-readiness indicators, but they should not be interpreted as definitive proof of efficacy. Larger prospectively registered trials with balanced groups, age-appropriate outcome measures, and stronger fidelity documentation are needed before firm recommendations can be made. FAU - Chikha, Anis Ben AU - Chikha AB AD - The Higher Institute of Sport and Physical Education (Ksar Said), University of Manouba, Manouba 2010, Tunisia. AD - Physical Activity, Sport and Health, Research Unit (UR18JS01), National Observatory of Sport, Tunis 1003, Tunisia. FAU - Eken, Ozgur AU - Eken O AUID- ORCID: 0000-0002-5488-3158 AD - Department of Physical Education and Sport Teaching, Faculty of Sports Sciences, Inonu University, Malatya 44280, Turkiye. FAU - Arslanoglu, Birgul AU - Arslanoglu B AD - Department of Humanities and Social Sciences, Faculty of Sciences and Letters, Istanbul Technical University, Istanbul 34469, Turkiye. FAU - Lousaif, Rahma AU - Lousaif R AD - The Higher Institute of Sport and Physical Education (Ksar Said), University of Manouba, Manouba 2010, Tunisia. AD - Research Laboratory (LR23JS01) "Sport Performance, Health and Society", Higher Institute of Sport and Physical Education of Ksar-Said, Manouba University, Tunis 2010, Tunisia. FAU - Goumni, Chiraz AU - Goumni C AD - The Higher Institute of Sport and Physical Education (Ksar Said), University of Manouba, Manouba 2010, Tunisia. AD - Research Laboratory (LR23JS01) "Sport Performance, Health and Society", Higher Institute of Sport and Physical Education of Ksar-Said, Manouba University, Tunis 2010, Tunisia. FAU - Bouallegui, Nejha AU - Bouallegui N AD - The Higher Institute of Sport and Physical Education (Ksar Said), University of Manouba, Manouba 2010, Tunisia. AD - Research Laboratory (LR23JS01) "Sport Performance, Health and Society", Higher Institute of Sport and Physical Education of Ksar-Said, Manouba University, Tunis 2010, Tunisia. FAU - Calisir, Melih AU - Calisir M AUID- ORCID: 0000-0002-2133-2843 AD - Department of Physical Education and Sport Teaching, Faculty of Sports Sciences, Bitlis Eren University, Bitlis 13000, Turkiye. FAU - Souissi, Nizar AU - Souissi N AD - The Higher Institute of Sport and Physical Education (Ksar Said), University of Manouba, Manouba 2010, Tunisia. AD - Physical Activity, Sport and Health, Research Unit (UR18JS01), National Observatory of Sport, Tunis 1003, Tunisia. FAU - Aldhahi, Monira I AU - Aldhahi MI AUID- ORCID: 0000-0002-5255-4860 AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia. LA - eng GR - PNURSP2026R286/Princess Nourah bint Abdulrahman University/ PT - Journal Article DEP - 20260710 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13405789 OTO - NOTNLM OT - attention and inhibition OT - cognitively enriched movement OT - executive functions OT - preschool education OT - school readiness OT - visuospatial learning COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/10 CRDT- 2026/07/28 01:02 PHST- 2026/04/30 00:00 [received] PHST- 2026/06/30 00:00 [revised] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:02 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - bs16071162 [pii] AID - behavsci-16-01162 [pii] AID - 10.3390/bs16071162 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Jul 10;16(7):1162. doi: 10.3390/bs16071162. PMID- 42510090 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 16 IP - 14 DP - 2026 Jul 16 TI - Interpretable Machine Learning for Predicting Suboptimal 12-Month Growth Response to Recombinant Human Growth Hormone in Children with Idiopathic Short Stature: A Dual-Center External Validation Study. LID - 10.3390/diagnostics16142227 [doi] LID - 2227 AB - Background/Objectives: Individual responses to recombinant human growth hormone (rhGH) therapy in children with idiopathic short stature (ISS) vary substantially, limiting pretreatment decision-making. This study aimed to develop and externally validate an interpretable machine learning model for predicting suboptimal 12-month growth response to rhGH therapy. Methods: In this retrospective dual-center study, 901 children from Center 1 were used for model development and internal testing, and 51 children from Center 2 formed an independent external validation cohort. Routinely collected baseline demographic, laboratory, hormonal, radiographic, and family-history variables were used to develop multiple machine learning models. A soft-voting ensemble classifier was constructed and interpreted using SHapley Additive exPlanations (SHAP). The primary outcome was suboptimal growth response, defined as failure to achieve a height gain of at least 0.5 standard deviation score after 12 months of treatment. Results: The optimized ensemble model showed strong discrimination in the internal test set, with an area under the receiver operating characteristic curve of 0.927, and maintained robust performance in the external validation cohort, with an AUC of 0.897. SHAP analysis identified luteinizing hormone, body mass index, TW3 RUS bone age, and insulin-like growth factor 1 as the leading contributors to predicted suboptimal-response risk. Conclusions: An interpretable ensemble machine learning model based on routinely available pretreatment data can predict suboptimal short-term rhGH response in children with ISS and may support individualized risk stratification in pediatric endocrine practice. Clinical trial registration was not required because this was a retrospective analysis. FAU - Yang, Chuanyu AU - Yang C AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Shao, Yifeng AU - Shao Y AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of General Surgery, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Jiang, Chengyang AU - Jiang C AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of General Surgery, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Zhang, Runmin AU - Zhang R AD - China United Network Communications Group, Beijing Branch, Beijing 100009, China. FAU - Wang, Jian AU - Wang J AD - Department of Pediatrics, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing 102218, China. FAU - Chen, Xinlin AU - Chen X AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Zeng, Yuyuan AU - Zeng Y AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - An, Qi AU - An Q AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Peng, Nan AU - Peng N AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Wang, Xi AU - Wang X AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Zhou, Bo AU - Zhou B AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Wang, Jianhong AU - Wang J AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. FAU - Wang, Lin AU - Wang L AUID- ORCID: 0000-0001-5536-781X AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100020, China. AD - Department of Child Health Care, Capital Center for Children's Health, Capital Medical University, Beijing 100020, China. LA - eng GR - 2024-1-1131/the Special Research Project of Capital Health Development/ GR - AL-02-19/High-level Public Health Talents Training Plan/ GR - XZYC-2025-07/New Quality Foundation of Capital Institute of Pediatrics/ PT - Journal Article DEP - 20260716 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC13408863 OTO - NOTNLM OT - clinical prediction model OT - idiopathic short stature OT - interpretability OT - machine learning OT - recombinant human growth hormone COIS- Author Runmin Zhang was employed by China United Network Communications Group, Beijing Branch. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/16 CRDT- 2026/07/28 01:01 PHST- 2026/06/10 00:00 [received] PHST- 2026/07/10 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - diagnostics16142227 [pii] AID - diagnostics-16-02227 [pii] AID - 10.3390/diagnostics16142227 [doi] PST - epublish SO - Diagnostics (Basel). 2026 Jul 16;16(14):2227. doi: 10.3390/diagnostics16142227. PMID- 42509980 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jul 20 TI - Correlation Between Ambulatory Blood Pressure Monitoring and Target Organ Damage in Children. LID - 10.3390/children13070955 [doi] LID - 955 AB - BACKGROUND: Ambulatory blood pressure monitoring (ABPM) offers a comprehensive assessment of mean blood pressure (BP), circadian patterns, and out-of-office hypertension phenotypes. We evaluated the association of ABPM parameters with left ventricular hypertrophy (LVH) and hypertensive retinopathy (HRP) in children with hypertension. METHODS: This retrospective analysis included 269 children who underwent ABPM at a tertiary care facility. Multivariable logistic regression was used to evaluate associations between BP Z scores and target organ damage (TOD), adjusting for age, sex, and body mass index standard deviation score. Machine learning techniques (logistic regression, random forest, and multilayer perceptron) were also evaluated using 10-fold cross-validation across exploratory combinations of the 90th or 95th percentiles and BP-load thresholds of 25% or 50%. RESULTS: LVH was detected in 45/247 patients (18%) and HRP was observed in 22/240 patients (9%). The 24 h systolic BP Z score was independently associated with LVH (adjusted OR 1.44; 95% CI 1.16-1.80; p = 0.001). Cohort-derived systolic Z-score thresholds for LVH were 1.31 for 24 h systolic BP and 1.47 for nighttime systolic BP, corresponding to approximately the 90.6th and 93rd percentiles, respectively. No variable evaluated was independently associated with retinopathy. Logistic regression using the 90th percentile/25% load dataset showed the highest performance among the evaluated classifiers, but discrimination was limited (ROC area 0.603; MCC 0.041). CONCLUSIONS: Higher ambulatory systolic BP was independently associated with LVH but not with clinically detected hypertensive retinopathy. ABPM values at or above the 90th percentile and a systolic load of >/=25% may help identify children at increased risk of TOD, although these thresholds remain exploratory and require prospective external validation. FAU - Ozturk, Musa AU - Ozturk M AUID- ORCID: 0000-0003-4316-2002 AD - Department of Pediatrics, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. FAU - Bakirarar, Batuhan AU - Bakirarar B AUID- ORCID: 0000-0002-5662-8193 AD - Department of Biostatistics, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. FAU - Ozcakar, Zeynep Birsin AU - Ozcakar ZB AUID- ORCID: 0000-0002-6376-9189 AD - Division of Pediatric Nephrology, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. FAU - Cakar, Nilgun AU - Cakar N AD - Division of Pediatric Nephrology, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. FAU - Doganay, Beyza AU - Doganay B AD - Department of Biostatistics, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. FAU - Tutar, Ercan AU - Tutar E AD - Division of Pediatric Cardiology, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. FAU - Yalcinkaya, Fatos AU - Yalcinkaya F AD - Division of Pediatric Nephrology, Ankara University Faculty of Medicine, Ankara 06100, Turkiye. LA - eng PT - Journal Article DEP - 20260720 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406871 OTO - NOTNLM OT - ambulatory blood pressure monitoring OT - childhood hypertension OT - left ventricular hypertrophy OT - machine learning OT - target organ damage COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/20 CRDT- 2026/07/28 01:01 PHST- 2026/06/18 00:00 [received] PHST- 2026/07/15 00:00 [revised] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - children13070955 [pii] AID - children-13-00955 [pii] AID - 10.3390/children13070955 [doi] PST - epublish SO - Children (Basel). 2026 Jul 20;13(7):955. doi: 10.3390/children13070955. PMID- 42509955 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jul 15 TI - Criterion and Convergent Validity of Youth Physical Activity and Sedentary Behavior Questionnaires in School Settings: A Systematic Review of Current Evidence and Future Perspectives. LID - 10.3390/children13070931 [doi] LID - 931 AB - BACKGROUND/OBJECTIVES: Physical activity and sedentary behavior are key indicators of youth health, and questionnaires offer a cost-effective method for data collection. This systematic review synthesized evidence on the criterion and convergent validity of self-report questionnaires measuring physical activity and sedentary behavior in children and adolescents aged 5-18 years in school settings. METHODS: Searches were conducted in SPORTDiscus, Medline, Scopus, ERIC, Academic Search Complete, Education Source, and the Cochrane Library with no date limits. Included studies compared questionnaire results with established measures and were assessed using the consensus-based standards for the selection of health measurement instruments (COSMIN) checklist. RESULTS: Twenty-two studies covering 16 questionnaires were included; additional outcomes included test-retest reliability, content and construct validity, and psychometric evaluation. Validity correlations ranged from very weak to strong (r = 0.11-0.80; rho = 0.20-0.87), with Bland-Altman agreement (rho = 0.56-0.70) and mean absolute percentage error up to 199.6%. CONCLUSIONS: Eight questionnaires showed acceptable validity and reliability, though research is needed to strengthen evidence on measurement accuracy. FAU - Gagnon, Megane AU - Gagnon M AD - Department of Human Kinetics, Universite du Quebec a Trois-Rivieres, 3351 des Forges Blvd. P.O. Box 500, Trois-Rivieres, QC G8Z 4M3, Canada. FAU - Bouqartacha, Salma AU - Bouqartacha S AUID- ORCID: 0009-0000-6749-3047 AD - Department of Anatomy, Universite du Quebec a Trois-Rivieres, 3351 des Forges Blvd. P.O. Box 500, Trois-Rivieres, QC G8Z 4M3, Canada. FAU - Bedard, Eloane AU - Bedard E AD - Department of Human Kinetics, Universite du Quebec a Trois-Rivieres, 3351 des Forges Blvd. P.O. Box 500, Trois-Rivieres, QC G8Z 4M3, Canada. FAU - Delattre, Livia AU - Delattre L AD - Department of Human Kinetics, Universite du Quebec a Trois-Rivieres, 3351 des Forges Blvd. P.O. Box 500, Trois-Rivieres, QC G8Z 4M3, Canada. FAU - Descarreaux, Martin AU - Descarreaux M AD - Department of Human Kinetics, Universite du Quebec a Trois-Rivieres, 3351 des Forges Blvd. P.O. Box 500, Trois-Rivieres, QC G8Z 4M3, Canada. FAU - Guimaraes, Roseane de Fatima AU - Guimaraes RF AUID- ORCID: 0000-0001-8151-7914 AD - Department of Human Kinetics, Universite du Quebec a Trois-Rivieres, 3351 des Forges Blvd. P.O. Box 500, Trois-Rivieres, QC G8Z 4M3, Canada. LA - eng GR - CMDO/FRQS 35330/Research Network on cardiometabolic health, diabetes and obesity/ GR - UQTR institutional Research Chair on lifestyle habits and health in youth/University of Quebec at Trois-Rivieres/ PT - Journal Article PT - Review DEP - 20260715 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406170 OTO - NOTNLM OT - children and adolescents OT - physical activity OT - questionnaire validity OT - sedentary behavior OT - systematic review COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/15 CRDT- 2026/07/28 01:01 PHST- 2026/06/12 00:00 [received] PHST- 2026/07/07 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - children13070931 [pii] AID - children-13-00931 [pii] AID - 10.3390/children13070931 [doi] PST - epublish SO - Children (Basel). 2026 Jul 15;13(7):931. doi: 10.3390/children13070931. PMID- 42509940 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jul 10 TI - Non-Pharmacological and Non-Optical Interventions for Myopia Prevention and Control in Children: A Systematic Review and Meta-Analysis. LID - 10.3390/children13070915 [doi] LID - 915 AB - BACKGROUND: Myopia is projected to affect 50% of the global population by 2050. Its progression increases the risk of severe ocular pathologies, making it imperative to validate safe and effective non-pharmacological prevention interventions. AIM: To evaluate the clinical efficacy of low-level red-light therapy (RLRL) and nutritional supplementation in preventing and controlling myopia progression in children and adolescents. METHODS: This systematic review and meta-analysis followed PRISMA guidelines and was registered in PROSPERO (CRD420261301596). Randomized clinical trials in pediatric populations (aged 0-18 years) were included. The primary quantitative outcome measures for myopia were axial length (AL) and spherical equivalent (SE). Risk of bias (RoB 2) and heterogeneity (I(2)) were assessed. RESULTS: 18 articles were included (n = 2438). RLRL demonstrated a significant reduction in axial elongation (mean difference (MD): -0.26 mm; 95% CI: -0.34 to -0.18) and a protective effect on refractive progression (MD: +0.60 D; 95% CI: 0.42 to 0.78), although with high heterogeneity (I(2) > 97%). Nutritional supplementation exhibited a modest, non-significant effect on axial length (-0.22 mm; 95% CI: -0.44 to 0.00), acting primarily as functional support. CONCLUSIONS: RLRL slows ocular elongation and myopia progression. Recent studies provide reassuring evidence regarding its long-term safety when recommended treatment protocols are followed. However, the high heterogeneity among studies, the need for standardized treatment discontinuation strategies, and the limited long-term evidence in geographically and ethnically diverse pediatric populations warrant further investigation. Current evidence is insufficient to demonstrate a consistent clinically meaningful effect of nutritional supplementation on axial elongation. FAU - Dominguez-Morras, Claudia AU - Dominguez-Morras C AD - Faculty of Science, Universidad Publica de Navarra, UPNA, 31008 Pamplona, Spain. FAU - Paniagua Garcia, Miren AU - Paniagua Garcia M AD - Department of Pediatrics, Hospital Universitario de Navarra, HUN, 31008 Pamplona, Spain. FAU - Castro Garrido, Isabel AU - Castro Garrido I AD - Department of Pediatrics, Hospital Universitario de Navarra, HUN, 31008 Pamplona, Spain. FAU - Moreno-Montanes, Javier AU - Moreno-Montanes J AUID- ORCID: 0000-0002-6623-6783 AD - Department of Ophthalmology, Hospital Fundacion Jimenez Diaz, 28040 Madrid, Spain. FAU - Fernandez-Montero, Alejandro AU - Fernandez-Montero A AUID- ORCID: 0000-0002-8741-7401 AD - Instituto de Investigacion Sanitaria de Navarra, IdiSNA, 31008 Pamplona, Spain. AD - Department of Occupational Medicine, Universidad de Navarra, 31008 Pamplona, Spain. FAU - Moreno-Galarraga, Laura AU - Moreno-Galarraga L AUID- ORCID: 0000-0003-0293-0749 AD - Faculty of Science, Universidad Publica de Navarra, UPNA, 31008 Pamplona, Spain. AD - Department of Pediatrics, Hospital Universitario de Navarra, HUN, 31008 Pamplona, Spain. AD - Instituto de Investigacion Sanitaria de Navarra, IdiSNA, 31008 Pamplona, Spain. LA - eng PT - Journal Article PT - Review DEP - 20260710 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406435 OTO - NOTNLM OT - axial length OT - children OT - dietary supplements OT - low-level light therapy OT - myopia OT - photobiomodulation OT - prevention and control OT - spherical equivalent COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/10 CRDT- 2026/07/28 01:01 PHST- 2026/05/22 00:00 [received] PHST- 2026/06/29 00:00 [revised] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - children13070915 [pii] AID - children-13-00915 [pii] AID - 10.3390/children13070915 [doi] PST - epublish SO - Children (Basel). 2026 Jul 10;13(7):915. doi: 10.3390/children13070915. PMID- 42509931 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jul 8 TI - Validity and Reliability of the Spanish Version of the Children's Self-Perceptions of Adequacy in and Predilection for Physical Activity (CSAPPA) Questionnaire for Primary School Children Aged 6 to 12 Years. LID - 10.3390/children13070906 [doi] LID - 906 AB - INTRODUCTION: Understanding children's physical self-concept is crucial, as it influences motivation, behavior, and physical activity (PA). The Spanish version of the Children's Self-Perceptions of Adequacy in and Predilection for Physical Activity (CSAPPA) assesses the adequacy and predilection for PA, but it is not fully adapted for schoolchildren. Considering the developmental and contextual differences between children and adolescents, adapting and validating this instrument for younger populations is necessary. This study aimed to test the validity and reliability of the CSAPPA for schoolchildren aged 6-12 years (65 boys and 64 girls; mean age 9.63 +/- 1.78 years). METHOD: Comprehension of the CSAPPA was examined through cognitive interviews, and reliability was assessed via a test-retest approach with 129 Spanish schoolchildren. Confirmatory factor analysis (CFA), Cronbach's alpha, and the intraclass correlation coefficient (ICC) were used to evaluate validity and reliability. RESULTS: CFA confirmed the three-factor structure (Adequacy, Predilection, Enjoyment) in children aged 6-12, with excellent fit indices: Chi-square divided by degrees of freedom (chi(2)/df) = 1.179; Root Mean Square Error of Approximation (RMSEA) = 0.037; Comparative Fit Index (CFI) = 0.961; Tucker-Lewis Index (TLI) = 0.953. Test-retest reliability ranged from questionable to good (Cronbach's alpha = 0.622-0.871), except for items 8 and 14. The ICC values indicated moderate to near-perfect (ICC: 0.453-0.871) temporal stability; items 8 and 14 were excluded. CONCLUSIONS: The Spanish CSAPPA demonstrates validity and reliability for assessing self-perceptions related to PA motivation among schoolchildren aged 6-12. As part of the affective domain in the Spanish Physical Literacy Assessment for Children (SPLA-C) model, it shows promise for use in school and sport contexts, supporting the identification of needs and planning interventions to promote active participation and positive development. However, items 8 and 14 demonstrated poor psychometric performance and should be interpreted with caution, requiring further refinement before the instrument can be recommended without reservation. FAU - Pastor-Cisneros, Raquel AU - Pastor-Cisneros R AUID- ORCID: 0000-0001-7305-6783 AD - Physical Activity for Education, Performance and Health (PAEPH) Research Group, Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. FAU - Mendoza-Munoz, Maria AU - Mendoza-Munoz M AUID- ORCID: 0000-0001-9502-5486 AD - Department of Communication and Education, Universidad Loyola Andalucia, 41704 Sevilla, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - School of Medicine, Universidad Espiritu Santo, Samborondon 0901952, Ecuador. AD - Faculty of Health Sciences, Universidad Autonoma de Chile, Temuco 4780000, Chile. FAU - Carlos-Vivas, Jorge AU - Carlos-Vivas J AUID- ORCID: 0000-0002-6377-9950 AD - Physical Activity for Education, Performance and Health (PAEPH) Research Group, Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. LA - eng PT - Journal Article DEP - 20260708 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406152 OTO - NOTNLM OT - educational assessment OT - motivation OT - physical education OT - young children COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/08 CRDT- 2026/07/28 01:01 PHST- 2026/06/02 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/04 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - children13070906 [pii] AID - children-13-00906 [pii] AID - 10.3390/children13070906 [doi] PST - epublish SO - Children (Basel). 2026 Jul 8;13(7):906. doi: 10.3390/children13070906. PMID- 42509924 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jul 6 TI - Chronic Skin Disease, Media Use and Health Values in the Quality of Life of Adolescents. LID - 10.3390/children13070899 [doi] LID - 899 AB - INTRODUCTION: Chronic dermatological diseases that appear in adolescence, such as acne vulgaris, atopic dermatitis, alopecia areata and psoriasis vulgaris, not only cause physical symptoms but also significantly affect young people's quality of life, mental state, self-esteem and social relationships. Social media, especially information spread by influencers, significantly influences adolescents' body image, health-related attitudes and even the quality of the physician-patient relationship. The aim of our study was to explore the relationships between dermatology-related quality of life, media use, health values, body image and self-esteem among adolescents with chronic dermatological diseases. METHODS: In our cross-sectional, quantitative study, we used validated questionnaires (DLQI, EQ-5D-5L, IRVS, Attitude Scale, STAI-Y2, SWLS-H, Rosenberg Scale, BAT), which we supplemented with a media consumption questionnaire of our own design. Structured data collection took place between October 2024 and March 2025, with the participation of 208 adolescents aged 11-18. Data analysis was performed using SPSS 26.0 (Spearman's correlation, Mann-Whitney test). Differences were considered significant at p < 0.05. Ethical approval: BM/22429-1/2024. RESULTS: Acne vulgaris was the most common diagnosis (65%), followed by atopic dermatitis (22%) and psoriasis (11%). Over a quarter of the adolescents (27%) followed influencers who provided skincare advice. The mean daily screen time was 4.5 h, with 3.7 h on smartphones. A longer screen time was significantly correlated with poorer dermatological quality of life. Greater dermatology-related quality of life impairment (higher DLQI scores) was associated with poorer general quality of life (EQ-5D-5L). Following skincare-related influencers was significantly associated with dermatology-related quality of life and anxiety. Conversely, stronger health values were significantly linked to more favourable health behaviors. CONCLUSIONS: In this sample, greater dermatology-related quality-of-life impairment was associated with poorer psychosocial outcomes. Longer screen time was associated with poorer dermatology-related quality of life and less favourable psychosocial outcomes. The novelty of our study lies in the use of a self-developed media consumption questionnaire, which is suitable for the complex mapping of psychological and quality-of-life factors in adolescents. FAU - Dinnyes, Katalin Julianna AU - Dinnyes KJ AUID- ORCID: 0000-0002-1975-7535 AD - Health Behaviour and Development Group, Faculty of Health Sciences and Social Training, University of Szeged, H-6726 Szeged, Hungary. AD - Doctoral School of Education and Society, University of Pecs, H-7622 Pecs, Hungary. FAU - Csoma, Zsanett Renata AU - Csoma ZR AD - Health Behaviour and Development Group, Faculty of Health Sciences and Social Training, University of Szeged, H-6726 Szeged, Hungary. AD - Department of Dermatology and Allergology, Albert Szent-Gyorgyi Clinical Center, University of Szeged, H-6720 Szeged, Hungary. LA - eng PT - Journal Article DEP - 20260706 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406771 OTO - NOTNLM OT - adolescents OT - body image OT - dermatology OT - health values OT - psychodermatology OT - quality of life OT - screen time OT - self-esteem OT - social media use COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/07/06 CRDT- 2026/07/28 01:01 PHST- 2026/04/26 00:00 [received] PHST- 2026/06/30 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - children13070899 [pii] AID - children-13-00899 [pii] AID - 10.3390/children13070899 [doi] PST - epublish SO - Children (Basel). 2026 Jul 6;13(7):899. doi: 10.3390/children13070899. PMID- 42509878 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jun 24 TI - Do School Athletes Really Eat Better? Nutritional and Body Composition Differences in Saudi Adolescents. LID - 10.3390/children13070852 [doi] LID - 852 AB - Background: Obesity among Saudi adolescents has risen sharply, yet whether school athletic participation is associated with students showing improved dietary habits and better anthropometric profiles compared to those of their non-athlete peers remains unclear. This study compared anthropometric indices and dietary habits between school athletes and non-athletes in Riyadh. Methods: A cross-sectional study was conducted with 124 male secondary school students (70 athletes and 54 non-athletes aged 16-17 years) in Riyadh, Saudi Arabia. Athletes were defined as students who reported engaging in vigorous-intensity sport for >/=3 days/week for >/=60 min/session. BMI, body weight, and waist circumference were measured objectively. Dietary habit frequencies across ten food categories were assessed using the validated Arab Teens Lifestyle Study (ATLS) questionnaire. Independent samples t-tests and chi-square tests were used; effect sizes were calculated as Cohen's d. A Bonferroni-corrected threshold (p < 0.005) was applied for multiple dietary comparisons. Results: Athletes had significantly lower BMI (23.64 +/- 5.39 vs. 30.28 +/- 7.25 kg/m(2); p < 0.001, d = 1.06), body weight (p < 0.001, d = 0.93), and waist circumference (85.46 +/- 12.61 vs. 95.50 +/- 17.89 cm; p < 0.001, d = 0.66). Obesity prevalence was 15.7% among athletes versus 51.9% among non-athletes. Of ten dietary variables, only fresh fruit consumption showed a between-group difference (62.9% vs. 40.7% high-frequency; p = 0.010), which did not survive Bonferroni correction. Conclusions: School athletes demonstrated substantially better anthropometric profiles than their non-athlete peers, but dietary habit frequencies were largely similar across both groups. The high obesity prevalence among non-athletes underscores the need for school-based programs that combine structured physical activity with targeted nutrition education. FAU - Alshuwaier, Ghareeb O AU - Alshuwaier GO AUID- ORCID: 0000-0003-3269-9509 AD - Department of Exercise Physiology, College of Sport Sciences and Physical Activity, King Saud University, Riyadh 11451, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406725 OTO - NOTNLM OT - Arab adolescents OT - Saudi Vision 2030 OT - central obesity OT - cross-sectional study OT - food frequency OT - overweight OT - physical inactivity OT - school sport COIS- The author declares no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/06/24 CRDT- 2026/07/28 01:01 PHST- 2026/05/26 00:00 [received] PHST- 2026/06/15 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - children13070852 [pii] AID - children-13-00852 [pii] AID - 10.3390/children13070852 [doi] PST - epublish SO - Children (Basel). 2026 Jun 24;13(7):852. doi: 10.3390/children13070852. PMID- 42509874 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260729 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 7 DP - 2026 Jun 24 TI - Effectiveness of a School Physician-Led Counseling Intervention on Cholesterol Levels and Lifestyle Behaviors in Children with Hypercholesterolemia: A Randomized Controlled Trial. LID - 10.3390/children13070848 [doi] LID - 848 AB - Background: This randomized controlled trial aimed to evaluate the effects of a school physician-led counseling intervention on total cholesterol (TC) levels, adherence to the Mediterranean diet, physical activity, and sedentary behavior in children aged 6-7 years with elevated cholesterol levels in a Mediterranean setting. Methods: A one-year randomized controlled study was conducted among children aged 6-7 years with elevated TC levels, excluding those with familial hypercholesterolemia (FH). Participants were randomly assigned to either a control group (n = 38) or an intervention group (n = 39). All participants received standard care consisting of educational materials and baseline counseling, while the intervention group additionally participated in three structured follow-up counseling sessions conducted by school physicians during the one-year study period. Counseling focused on Mediterranean dietary habits, implementation of basic dietary principles in cases of elevated TC levels, promotion of physical activity, and reduction in sedentary behavior. TC levels were measured at baseline and at the end of the study. Dietary habits, physical activity, and sedentary behavior were assessed using validated questionnaires. For the primary outcome, a descriptive change-from-baseline analysis, unadjusted mean difference, the approximate 95% confidence interval, and Cohen's d effect size were calculated. Results: At baseline, no significant differences in TC levels were observed between groups (p = 0.852). After the intervention, mean TC levels were lower in the intervention group than in the control group (4.977 +/- 0.414 mmol/L vs. 5.137 +/- 0.410 mmol/L); however, the between-group difference did not reach statistical significance (p = 0.089). The unadjusted mean difference at follow-up was -0.160 mmol/L, with an approximate 95% confidence interval from -0.35 to 0.03 and a small-to-moderate effect size in favor of the intervention group (Cohen's d = -0.39). Descriptive change-from-baseline analysis showed a greater mean reduction in TC in the intervention group than in the control group (-0.364 mmol/L vs. -0.195 mmol/L). A statistically significant improvement in adherence to the Mediterranean diet was observed in the intervention group compared with the control group (p < 0.001). Favorable changes were also observed in several physical activity and sedentary behavior variables, including participation in organized physical activity, walking and running activities, and reduced television viewing and video gaming time. Given the exploratory nature of behavioral analyses and the number of physical activity and sedentary behavior outcomes examined, these findings should be interpreted cautiously. Conclusions: The school physician-led counseling intervention did not result in a statistically significant between-group difference in TC levels after one year, although the direction and magnitude of change favored the intervention group. The intervention was associated with improved adherence to the Mediterranean diet and favorable exploratory lifestyle-related behavioral changes. Nevertheless, the findings should be interpreted cautiously in light of the relatively small sample size, non-significant primary outcome, and exploratory nature of behavioral analyses. FAU - Tomelic Ercegovic, Katarina AU - Tomelic Ercegovic K AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. FAU - Glavas, Josipa AU - Glavas J AUID- ORCID: 0000-0002-8032-3269 AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. FAU - Sikirica, Ivana AU - Sikirica I AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. FAU - Vrdoljak, Andrea AU - Vrdoljak A AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. FAU - Tokic, Helena AU - Tokic H AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. FAU - Perasovic, Jelica AU - Perasovic J AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. FAU - Karin, Zeljka AU - Karin Z AD - Department of School and Adolescent Medicine, Teaching Institute for Public Health, Split-Dalmatia County, 21000 Split, Croatia. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13406426 OTO - NOTNLM OT - Mediterranean diet OT - children OT - hypercholesterolemia OT - intervention OT - physical activity OT - prevention COIS- The authors declare no conflicts of interest. EDAT- 2026/07/28 06:37 MHDA- 2026/07/28 06:38 PMCR- 2026/06/24 CRDT- 2026/07/28 01:01 PHST- 2026/05/28 00:00 [received] PHST- 2026/06/18 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/28 06:38 [medline] PHST- 2026/07/28 06:37 [pubmed] PHST- 2026/07/28 01:01 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - children13070848 [pii] AID - children-13-00848 [pii] AID - 10.3390/children13070848 [doi] PST - epublish SO - Children (Basel). 2026 Jun 24;13(7):848. doi: 10.3390/children13070848. PMID- 42509549 OWN - NLM STAT- MEDLINE DCOM- 20260728 LR - 20260813 IS - 1465-993X (Electronic) IS - 1465-9921 (Print) IS - 1465-9921 (Linking) VI - 27 IP - 1 DP - 2026 Jul 27 TI - Increased high sensitivity C-reactive protein in more severe wheeze/asthma phenotypes in child- and adulthood in ALLIANCE. LID - 10.1186/s12931-026-03840-x [doi] LID - 294 AB - BACKGROUND: The relevance of high-sensitivity C-reactive protein (hsCRP), a marker of low-grade systemic inflammation, remains unclear with regard to its association with severity and clinical outcomes in wheeze/asthma. We aimed to assess the role of hsCRP across different phenotypes and severity levels. METHODS: We studied children with preschool wheeze (>/= 2 episodes), and patients with GINA-defined asthma (school-age/adult) compared with healthy controls (HCs) in the well-characterized ALLIANCE (All Age Asthma Cohort) study. HsCRP was measured (AU5800(R)-CRP-Latex test) in 944 study participants (pediatric: n = 728; adult: n = 216) at baseline. Age-stratified analyses (age groups 0-5, 6-18, >/= 18 years) of standardized log(10)-transformed hsCRP concentrations (age, sex, BMI, site) were performed using univariable tests and regression models. The validated ASSESS score and its dimensions (exacerbations, lung function, inhaled corticosteroids, symptom control) were primary outcomes. RESULTS: Adult patients with asthma showed higher hsCRP than HCs (OR 2.22, 95% CI 1.56-3.24). Across all ages, hsCRP increased with clinical severity of wheeze/asthma. The ASSESS score correlated positively with hsCRP in patients aged >/= 6 years (R = 0.19, p = 0.007). hsCRP was increased in school-age asthmatics with prior exacerbations (OR 1.37, 95% CI 1.01-1.87), and in adult asthmatics with impaired lung function (R = 0.2, p = 0.013). Inhaled corticosteroid use was associated with lower hsCRP in preschool wheezers (OR 0.66, 95% CI 0.50-0.85) but higher levels in adults (OR 1.99, 95% CI 1.02-4.09). CONCLUSIONS: HsCRP was increased in adult asthmatics compared to HCs and was associated with several severity-related clinical characteristics. ICS use was associated with higher hsCRP levels in adults, potentially reflecting greater disease severity, whereas ICS use in preschool wheezers was associated with lower hsCRP levels. These age-dependent effects may mirror varying disease courses across the lifespan and progression of asthma. The association of hsCRP with asthma severity in child- and adulthood may indicate its potential relevance for the course of disease and monitoring clinical outcomes. Future longitudinal studies are needed to assess, whether hsCRP may support therapy monitoring. TRIAL REGISTRATION: ClinicalTrials.gov; Pediatric arm: NCT02496468, Registration date: 03 July 2015; Adult arm: NCT02419274, Registration date: 14 April 2015. CI - (c) 2026. The Author(s). FAU - Lagally, Lena AU - Lagally L AUID- ORCID: 0009-0001-9798-9737 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. AD - Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Pettenkofer School of Public Health, Munich, Germany. FAU - Ullemeyer, Lena AU - Ullemeyer L AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. FAU - Omony, Jimmy AU - Omony J AUID- ORCID: 0000-0001-9983-1039 AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. AD - Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. FAU - Gottschau, Kristina AU - Gottschau K AUID- ORCID: 0000-0002-0785-9964 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. FAU - Foppiano, Francesco AU - Foppiano F AUID- ORCID: 0009-0002-5650-9984 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Institute for Medical Information Processing, Biometry, and Epidemiology (IBE), LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Pettenkofer School of Public Health, Munich, Germany. FAU - Abdo, Mustafa AU - Abdo M AD - LungenClinic Grosshansdorf GmbH, Grosshansdorf, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany. AD - Department of Pneumology and Critical Care Medicine, Thoraxklinik at Heidelberg University Hospital, Translational Lung Research Center Heidelberg, Heidelberg, Germany. FAU - Veith, Vera AU - Veith V AUID- ORCID: 0009-0002-8731-9702 AD - LungenClinic Grosshansdorf GmbH, Grosshansdorf, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany. FAU - Tholken, Clemens AU - Tholken C AUID- ORCID: 0000-0003-4328-9193 AD - Center for Synthetic Microbiology (SYNMIKRO), Philipps-Universitat Marburg, Marburg, Germany. FAU - Hose, Alexander AU - Hose A AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. FAU - Maison, Nicole AU - Maison N AUID- ORCID: 0000-0002-8731-4218 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. AD - Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. FAU - Grychtol, Ruth AU - Grychtol R AUID- ORCID: 0000-0002-8084-104X AD - Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. AD - Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany. FAU - Dittrich, Anna-Maria AU - Dittrich AM AUID- ORCID: 0000-0002-9582-1025 AD - Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. AD - Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany. AD - Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany. FAU - Riemann, Lennart AU - Riemann L AUID- ORCID: 0000-0002-7188-5227 AD - Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. AD - Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany. AD - Institute of Immunology, Hannover Medical School, Hannover, Germany. FAU - Weckmann, Markus AU - Weckmann M AUID- ORCID: 0000-0001-5342-979X AD - University Children's Hospital, Luebeck, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Luebeck, Germany. AD - Division of Epigenetics in Chronic Lung Disease, Priority Area Chronic Lung Diseases, Leibniz Lung Center, Research Center Borstel, Borstel, Germany. FAU - Konig, Inke AU - Konig I AUID- ORCID: 0000-0003-0504-6465 AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Luebeck, Germany. AD - Institute for Medical Biometry and Statistics, University Luebeck, University Medical Centre Schleswig-Holstein, Campus Luebeck, Luebeck, Germany. FAU - Kronziel, Lea AU - Kronziel L AUID- ORCID: 0000-0002-2126-6831 AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Luebeck, Germany. AD - Institute for Medical Biometry and Statistics, University Luebeck, University Medical Centre Schleswig-Holstein, Campus Luebeck, Luebeck, Germany. FAU - Illi, Sabina AU - Illi S AUID- ORCID: 0000-0003-4994-7732 AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. AD - Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. FAU - van Koningsbruggen-Rietschel, Silke AU - van Koningsbruggen-Rietschel S AUID- ORCID: 0000-0002-2222-4238 AD - Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. FAU - Rabe, Klaus F AU - Rabe KF AUID- ORCID: 0000-0002-7020-1401 AD - LungenClinic Grosshansdorf GmbH, Grosshansdorf, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany. FAU - Renz, Harald AU - Renz H AUID- ORCID: 0000-0003-0602-7215 AD - Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University of Marburg, Marburg, Germany. AD - University of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Giessen, Germany. FAU - Hansen, Gesine AU - Hansen G AUID- ORCID: 0000-0001-5185-9454 AD - Department of Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany. AD - Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany. AD - Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany. FAU - Brinkmann, Folke AU - Brinkmann F AUID- ORCID: 0000-0002-4307-4232 AD - University Children's Hospital, Luebeck, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Luebeck, Germany. FAU - Kopp, Matthias V AU - Kopp MV AUID- ORCID: 0000-0003-1989-5492 AD - University Children's Hospital, Luebeck, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Luebeck, Germany. AD - Department of Paediatric Respiratory Medicine, Inselspital, University Children's Hospital of Bern, University of Bern, Bern, Switzerland. FAU - von Mutius, Erika AU - von Mutius E AUID- ORCID: 0000-0002-8893-4515 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. AD - Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. FAU - Bahmer, Thomas AU - Bahmer T AUID- ORCID: 0000-0002-7677-7057 AD - LungenClinic Grosshansdorf GmbH, Grosshansdorf, Germany. AD - Airway Research Center North (ARCN), German Center for Lung Research (DZL), Grosshansdorf, Germany. FAU - Ege, Markus AU - Ege M AUID- ORCID: 0000-0001-6643-3923 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. AD - Institute for Asthma and Allergy Prevention (IAP), Helmholtz Zentrum Munich, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. FAU - Skevaki, Chrysanthi AU - Skevaki C AUID- ORCID: 0009-0006-7522-3294 AD - Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, University of Marburg, Marburg, Germany. AD - University of Giessen and Marburg Lung Center (UGMLC), German Center for Lung Research (DZL), Giessen, Germany. AD - Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, USA. AD - Centre for Research and Education in Public Health (CEPHRE), Academy of Athens, Athens, Greece. FAU - Schaub, Bianca AU - Schaub B AUID- ORCID: 0000-0003-1652-8873 AD - Department of Paediatric Allergology, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. Bianca.Schaub@med.uni-muenchen.de. AD - Comprehensive Pneumology Center, Munich (CPC-M), German Center for Lung Research (DZL), Munich, Germany. Bianca.Schaub@med.uni-muenchen.de. AD - German Center for Child and Adolescent Health (DZKJ), Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Medizin, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. Bianca.Schaub@med.uni-muenchen.de. CN - ALLIANCE Study Group LA - eng SI - ClinicalTrials.gov/NCT02496468 SI - ClinicalTrials.gov/NCT02419274 PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260727 PL - England TA - Respir Res JT - Respiratory research JID - 101090633 RN - 0 (Biomarkers) RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Adolescent MH - Adult MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Middle Aged MH - Young Adult MH - *Asthma/blood/diagnosis/epidemiology MH - Biomarkers/blood MH - *C-Reactive Protein/metabolism MH - Cohort Studies MH - *Phenotype MH - *Respiratory Sounds/diagnosis/physiopathology MH - *Severity of Illness Index PMC - PMC13412301 OTO - NOTNLM OT - Asthma OT - Asthma treatment OT - Clinical immunology OT - Epidemiology OT - Inflammation OT - Pediatrics OT - Wheeze COIS- Declarations. Ethics approval and consent to participate: This study involved human participants. A statement within the Methods section to confirm that informed consent was obtained is provided. The study was approved by local ethics committees (lead: University of Luebeck Ethics Committee; reference no. AZ 12-215) and conducted in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: LU, LL, JO, KG, FF, MA, VV, CT, AH, NM, LR, IK, LK, SI, HR, FB have nothing to declare. This work was supported by German Center for Lung Research (DZL) (RG, AMD, KR, GH, MK, ME, EvM, TB, CS, BS); German Federal Ministry of Education and Research (BMBF) (AMD, TB, EvM, GH) and RG: Else-Kroner Fresenius Stiftung; AMD: Vertex Pharmaceutical Inc., German Science Foundation, GSK, Oxford University, Novartis, Hogrefe Publishing Company, Department for Pediatric Psychology, Philipps University Marburg, Vertex Pharmaceuticals, StreamedUP, Christiane-Herzog-Foundation, Austrian Society for Rare Disease, Paul-Ehrlich-Institute, German CF Patient Advocacy Board, German CF Clinical Trial Network Executive Committee, ECFS CTN Executive Committee; MW: DFG, HORIZON-MSCA-2023, COVID-19 Research Initiative Schleswig-Holstein, Follow-Up of Respiratory Infections in Schleswig-Holstein (FRISH), intramural funding of the Christian-Albrechts-University Kiel, the University of Lubeck, and the Leibniz Lung Center, Research Center Borstel; SvKR: Wilsing Stiftung Koln; KR: AstraZeneca, Boehringer Ingelheim, Chiesie, Sanofi & Regeneron, Astra Zeneca, Chiesi Pharmaceuticals, CSL Behring, GlaxoSmithKline, Berlin Chemie, Menarini, German Chest Society (DGP), American Thoracic Society (ATS); GH: Sanofi GmbH, MedUpdate, Abbvie; MK: University of Bern, Allergopharma GmbH, Sanofi Aventis GmbH, Infectopharm GmbH, Gesellschaft Padiatrische Pneumologie e.V; EvM: Bavarian State Ministry of Health and Care for "URS Study", Go Bio Initial Grant, BMBF (Federal Ministry of Education and Research), European Research Council Award, "BEAR Study", O.M. Pharma S.A.; Elsevier GmbH, Georg Thieme Verlag, Springer-Verlag GmbH, Elsevier Ltd., Springer Nature Group, Deutscher Apotheker Verlag; Chinese University of Hongkong, European Commission, AstraZeneca, Imperial College London, OM Pharma S.A., Clarivate; ALK-Abello Arzneimittel GmbH, Japanese Society of Pediatric Allergy and Clinical Immunology (JSPACI), Klinikum Rechts der Isar, University of Colorado, Paul-Martini-Stiftung, Astra Zeneca BioPharmaceuticals Medical, Imperial College London, Children s Hospital Research, Institute of Manitoba Kompetenzzentrum fur Ernahrung (Kern), OM Pharma S.A., Swedish Pediatric Society for Allergy and Lung Medicine, Chinese College of Allergy and Asthma (CCAA), Abbott Laboratories, Deutscher Apotheker Verlag GmbH & Co. KG, Socieded Chilena de Enfermedades Respiratorias, Japanese Society of Allergology, British Society for Asthma and Clinical Immunology, American Academy of Allergy, Asthma & Immunology, European Respiratory Society (ERS), Ludwig Maximilians University Munich, French Health Research Programs' Agency, CONSORZIO FUTURO IN RICERCA, Technical University of Munich (TUM); Deutsches Zentrum fur Lungenforschung (DZL), Fabio Luigi Massimo Ricciardolo/Contatto S.r.l., Fraunhofer ITEM Hannover, MCCA Institut fur Immunologie Uni Wien, Karl-Landsteiner Privatuniversitat f. Gesundheitswissenschaften, Swiss Institute of Allergy and Asthma Research (SIAF) Davos (Associated Institute of the University of Zurich) MHH (Medizinische Hochschule Hannover), Natasha Allergy Research Foundation, Deutsche Forschungsgemeinschaft, Gordon Research Conferences, Socieded Chilena de Enfermedades Respiratorias, Arla, Universitat Leiden, OM Pharma S.A., American Academy of Allergy, Asthma & Clinical Immunology, Deutsche Forschungsgemeinschaft (DFG), European Respiratory Society (ERS), Deutsche Gesellschaft fur Kinder- und Jugendmedizin, World Allergy Organization (WAO), European Parliament, Gesellschaft fur Padiatrische Pneumologie (GPP), European Academy of Allergy and Clinical Immunology (EAACI), Helmholtz Association of German Research Centres, Nobel Conference Stockholm, AAA Congress Sarajevo, Karolinska Institutet, Balzan Foundation, Fondazione Menarini, International Union of Immunological Societies (IUIS), Deutsche Gesellschaft fur Allergologie und klinische Immunologie (DGAKI), Collegium Internationale Allergologicum, European Academy of Allergy & Clinical Immunology (EAACI); EvM has patent No. PCT/EP2019/085016 (Barn dust extract for the prevention and treatment of diseases) issued EU, pending US, Royalties paid to ProtectImmun for patent EP2361632 (Speci fi c environmental bacteria for the protection from and/or the treatment of allergic, chronic in fl ammatory and/or autoimmune disorders, granted on 19 March 2014), and patents EP1411977 (Composition containing bacterial antigens used for the prophylaxis and the treatment of allergic diseases, granted on 18 April 2007), EP1637147 (Stable dust extract for allergy protection, granted on 10 December 2008), and EP 1964570 (Pharmaceutical compound to protect against allergies and in fl ammatory diseases, granted on 21 November 2012) licensed to ProtectImmun. Patent EP21189353.2. 2021. von Mutius E, Rankl B, Bracher F, Muller C, Walker A, Hauck SM, Merl-Pham J, inventors; PROTEINS IDENTIFIED FROM BARN DUST EXTRACT FOR THE PREVENTION AND TREATMENT OF DISEASES. Patent PCT/US2021/016918. 2021. Martinez FD, Vercelli D, Snyder SA, von Mutius E, Pivniouk V, Marques dos Santos M, inventors; THERAPEUTIC FRACTIONS AND PROTEINS FROM ASTHMA-PROTECTIVE FARM DUST. Patent EP21189353.2. 2021. von Mutius E, Rankl B, Bracher F, Muller C, Walker A, Hauck SM, Merl-Pham J, Adler H, Yildirim A.O., Sattler M, Santos Dias Mourao A, Borggrafe J, O Connor P.D., Plettenburg O, inventors; PROTEINS IDENTIFIED FROM BARN DUST EXTRACT FOR THE PREVENTION AND TREATMENT OF DISEASES. Member of the BEAMS External Scientific Advisory Board (ESAB), Member of the Editorial Board of "The Journal of Allergy and Clinical Immunology: In Practice", Member of the Scientific Advisory Board of the Children's Respiratory and Environmental Workgroup (CREW), Member of the International Scientific & Societal Advisory Board (ISSAB) of Utrecht Life Sciences (ULS) University of Utrecht, Member of External Review Panel of the Faculty of Veterinary Science, University of Utrecht, Member of the Selection Committee for the Gottfried Wilhelm Leibniz Programme (DFG), Member of the International Advisory Board of "The Lancet Respiratory Medicine", Member of the Scientific Advisory Board of the CHILD (Canadian Healthy Infant Longitudinal Development) study, McMaster University, Hamilton, Canada, Member of the Pediatric Scientific Advisory Board Iceland, Member of the Abbott Allergy Risk Reduction Advisory Board, Member of the HpVac Scientific Advisory Board, Member of the OM Pharma Scientific Advisory Board, Member of the Award Committee of the International Balzan Foundation, Member of the Scientific Advisory Board for French Prevention National Research Programme, Member of the Scientific Advisory Panel for The Natasha Allergy Research Foundation; TB: Network University Medicine (NUM), Thieme, HealthHero, PneumoLounge, Pohl Boskamp, Pfizer, Chiesi, AstraZeneca, PohlBoskamp, German Society for Pneumology (DGP); ME: Latvian Council of Science, Travel Grant by the International Milk Genomics Consortium 2023 and by Dutch Longfunds 2025; CS: Consultancy and research funding, Bencard Allergie; Consultancy, Novartis Pharma GmbH; BS: GlaxoSmithKline, Novartis, Sanofi, Astra Zeneca, DGAKI. FIR - Burk, Mira IR - Burk M FIR - Contento, Sybille IR - Contento S FIR - Gschwendtner, Silvia IR - Gschwendtner S FIR - Jakwerth, Constanze IR - Jakwerth C FIR - Schloter, Michael IR - Schloter M FIR - Schmidt-Weber, Carsten IR - Schmidt-Weber C FIR - Zeitlmann, Esther IR - Zeitlmann E FIR - Biller, Heike IR - Biller H FIR - Blanke-Roeser, Constantin IR - Blanke-Roeser C FIR - Gaede, Karoline I IR - Gaede KI FIR - Hagedorn, Wiebke IR - Hagedorn W FIR - Jacobs, Nikolas IR - Jacobs N FIR - Kirsten, Anne-Marie IR - Kirsten AM FIR - Nissen, Gyde IR - Nissen G FIR - Nurieva, Wasifa IR - Nurieva W FIR - Pedersen, Frauke IR - Pedersen F FIR - Penner, Loana IR - Penner L FIR - Ricklefs, Isabell IR - Ricklefs I FIR - Szymczak, Silke IR - Szymczak S FIR - Waschki, Benjamin IR - Waschki B FIR - Watz, Henrik IR - Watz H FIR - Wirks, Christopher IR - Wirks C FIR - Bickes, Marie IR - Bickes M FIR - Calvero, Mifflin-Rae IR - Calvero MR FIR - DeLuca, David S IR - DeLuca DS FIR - Gaedcke, Svenja IR - Gaedcke S FIR - Habener, Anika IR - Habener A FIR - Happle, Christine IR - Happle C FIR - Jirmo, Adan Chari IR - Jirmo AC FIR - Liu, Bin IR - Liu B FIR - Foth, Svenja IR - Foth S FIR - Jerrentrup, Inga IR - Jerrentrup I FIR - Weber, Stefanie IR - Weber S FIR - Alejandre Alcazar, Miguel A IR - Alejandre Alcazar MA FIR - Keufken, Lena IR - Keufken L FIR - Rietschel, Ernst IR - Rietschel E FIR - Trojan, Tobias IR - Trojan T FIR - Thomassen, Jan-Christoph IR - Thomassen JC EDAT- 2026/07/28 00:35 MHDA- 2026/07/28 06:37 PMCR- 2026/07/27 CRDT- 2026/07/27 23:35 PHST- 2026/05/04 00:00 [received] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/07/28 06:37 [medline] PHST- 2026/07/28 00:35 [pubmed] PHST- 2026/07/27 23:35 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 10.1186/s12931-026-03840-x [pii] AID - 3840 [pii] AID - 10.1186/s12931-026-03840-x [doi] PST - epublish SO - Respir Res. 2026 Jul 27;27(1):294. doi: 10.1186/s12931-026-03840-x. PMID- 42509536 OWN - NLM STAT- MEDLINE DCOM- 20260728 LR - 20260813 IS - 1471-2369 (Electronic) IS - 1471-2369 (Linking) VI - 27 IP - 1 DP - 2026 Jul 25 TI - Examining commonly used equations for estimating the glomerular filtration rate (GFR) in a healthy cohort of children and adolescents. LID - 10.1186/s12882-026-05219-y [doi] LID - 446 AB - BACKGROUND: In this study, we compared established equations for estimating the glomerular filtration rate (GFR) in a cohort of apparently healthy children and adolescents and aimed to evaluate the equations' validity. METHODS: Blood samples and anthropometric data from 4,776 apparently healthy participants (0.25-21 years) were analyzed. The glomerular filtration rate was estimated (eGFR) using the revised Schwartz Bedside (2009), the Cystatin C- and Serum Creatinine- based Schwartz equation, the Chronic Kidney Disease in Children (CKiD) equation, the 3 versions of the U25 (U25cys, U25scr, U25ave), the Serum Creatinine version, as well as the Cystatin-C based equation from the European Kidney Function Consortium (EKFCcr, EKFCcys), the CAPA equation, and the Cystatin C-Creatinine-based Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). The resulting eGFR distributions were compared, and the percentages of eGFR values within the expected physiological eGFR range (90-120 ml/min/1.73 m(2)) were calculated stratified by age and sex. Subsequently, age ranges with implausible distributions were identified. RESULTS: EKFCcr, CKiD, Schwartz, and U25scr yielded the highest proportion of eGFRs within the expected range and showed consistent values across age groups without large jumps. Bland-Altman analysis indicated extremely low biases between Schwartz and EKFCcr and very high biases especially between CKD-EPI, CAPA and Bedside in reference to the other equations. Males showed higher eGFRs than females. CONCLUSIONS: We found that the EKFC equations, Schwartz, and U25 resulted in eGFR distributions within the expected physiological range for an apparently healthy pediatric cohort. Estimates from simpler equations such as Bedside and CAPA were more prone to implausible results. TRIAL REGISTRATION: Clinical trial number NCT02550236 (clinicaltrials.gov, date of registration: 2014-12-15). CI - (c) 2026. The Author(s). FAU - Trenkmann, Luise AU - Trenkmann L AUID- ORCID: 0009-0004-8680-1358 AD - LIFE Child Study, University Hospital for Children and Adolescents, Medical Faculty, Leipzig University, Philipp-Rosenthal-Strasse 27, 04103, Leipzig, Germany. luise@trenkmann.eu. FAU - Ziegelasch, Niels AU - Ziegelasch N AD - LIFE Child Study, University Hospital for Children and Adolescents, Medical Faculty, Leipzig University, Philipp-Rosenthal-Strasse 27, 04103, Leipzig, Germany. FAU - Dittrich, Katalin AU - Dittrich K AD - Center of Paediatric Research (CPL), University of Leipzig, 04103, Leipzig, Germany. AD - Hospital for Children and Adolescents, University of Leipzig, Liebigstrasse 20a, 04103, Leipzig, Germany. FAU - Willenberg, Anja AU - Willenberg A AD - Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics (ILM), University Hospital Leipzig, 04103, Leipzig, Germany. FAU - Kiess, Wieland AU - Kiess W AD - LIFE Child Study, University Hospital for Children and Adolescents, Medical Faculty, Leipzig University, Philipp-Rosenthal-Strasse 27, 04103, Leipzig, Germany. AD - Center of Paediatric Research (CPL), University of Leipzig, 04103, Leipzig, Germany. FAU - Vogel, Mandy AU - Vogel M AD - LIFE Child Study, University Hospital for Children and Adolescents, Medical Faculty, Leipzig University, Philipp-Rosenthal-Strasse 27, 04103, Leipzig, Germany. AD - Center of Paediatric Research (CPL), University of Leipzig, 04103, Leipzig, Germany. LA - eng SI - ClinicalTrials.gov/NCT02550236 PT - Journal Article PT - Observational Study DEP - 20260725 PL - England TA - BMC Nephrol JT - BMC nephrology JID - 100967793 RN - AYI8EX34EU (Creatinine) RN - 0 (Cystatin C) SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Young Adult MH - Cohort Studies MH - Creatinine/blood MH - Cystatin C/blood MH - *Glomerular Filtration Rate/physiology MH - Reference Values MH - Renal Insufficiency, Chronic/diagnosis PMC - PMC13410585 OTO - NOTNLM OT - Children OT - Creatinine OT - Cystatin C OT - Kidney OT - Pediatric OT - eGFR COIS- Declarations. Ethics approval and consent to participate: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards and have been approved by the Ethics Committee of the University of Leipzig (Reg. No. 477-19-09102020). Informed consent was obtained from all individual participants, or their legal guardians, included in the study. The study is registered under the NCT Trial Number: 02550236 at ClinicalTrials.gov, date of registration: 2014-12-15. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/28 00:35 MHDA- 2026/07/28 06:37 PMCR- 2026/07/25 CRDT- 2026/07/27 23:33 PHST- 2025/11/02 00:00 [received] PHST- 2026/07/16 00:00 [accepted] PHST- 2026/07/28 06:37 [medline] PHST- 2026/07/28 00:35 [pubmed] PHST- 2026/07/27 23:33 [entrez] PHST- 2026/07/25 00:00 [pmc-release] AID - 10.1186/s12882-026-05219-y [pii] AID - 5219 [pii] AID - 10.1186/s12882-026-05219-y [doi] PST - epublish SO - BMC Nephrol. 2026 Jul 25;27(1):446. doi: 10.1186/s12882-026-05219-y. PMID- 42509504 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20260928 IS - 1432-2218 (Electronic) IS - 0930-2794 (Print) IS - 0930-2794 (Linking) VI - 40 IP - 9 DP - 2026 Sep TI - Missing data handling in pediatric appendectomy research: current practices and National Surgical Quality Improvement Program (NSQIP) analysis. PG - 8068-8080 LID - 10.1007/s00464-026-13123-7 [doi] AB - BACKGROUND: Appendectomy is a leading pediatric surgical procedure, yet the impact of missing data handling on clinical conclusions remains unexplored in pediatric surgery. This study aimed to identify current reporting practices in the pediatric appendectomy literature and quantify how different missing-data strategies influence the identification of postoperative infectious-complication risk factors. METHODS: A systematic review of pediatric appendectomy literature from 2023 was conducted across PubMed and Web of Science to assess missing data reporting. Subsequently, a retrospective analysis of the National Surgical Quality Improvement Program-Pediatric (NSQIP-P) database (2015-2022) was performed on 142,129 cases. Five strategies were compared: available case analysis, threshold-based exclusion, complete case analysis, simple imputation, and multiple imputation. Multivariable logistic regression models identified risk factors for five infectious outcomes, including combined infectious complications, organ space infections, deep incisional infections, superficial surgical site infections, and wound dehiscence. RESULTS: The literature review identified 116 eligible articles, of which 54.3% failed to mention missing data. Only 7.3% used advanced statistical techniques, while 86.4% reported that a method relied on complete-case analysis. In the NSQIP-P cohort, 39.3% of records had missing values, primarily in height and race. While core predictors like American Society of Anesthesiologists (ASA) class and operative duration remained stable in multivariate logistic regression analysis, variables such as preoperative white blood cell count and anthropometric measurements fluctuated in significance depending on the handling method. Complete case analysis was the most conservative, identifying the fewest significant predictors. CONCLUSION: Methodological transparency regarding missing data is critically lacking in pediatric surgical research. Because the choice of data-handling strategy significantly alters the identification of clinical risk factors, researchers should prioritize multiple imputation over simple exclusion methods. Journals must mandate rigorous reporting of missingness to ensure the reliability of evidence-based surgical guidelines. CI - (c) 2026. The Author(s). FAU - Tsutsumi, Ayaka AU - Tsutsumi A AUID- ORCID: 0009-0008-6511-9666 AD - Department of Pediatric Surgery, SSM Health Cardinal Glennon Children's Hospital, 1465 S Grand Blvd, Saint Louis, MO, 63104, USA. ayaka.tsutsumi@health.slu.edu. FAU - Si, Tong AU - Si T AD - The Advanced Health Data (AHEAD) Institute, Saint Louis University Hospital, St. Louis, MO, USA. FAU - Salas, Joanne AU - Salas J AD - The Advanced Health Data (AHEAD) Institute, Saint Louis University Hospital, St. Louis, MO, USA. FAU - Hargrave, Anna AU - Hargrave A AD - Department of General Surgery, Saint Louis University Hospital, St. Louis, MO, USA. FAU - Trello, Grace AU - Trello G AD - School of Medicine, St. Louis University, St. Louis, MO, USA. FAU - Qiu, Jessica AU - Qiu J AD - School of Medicine, St. Louis University, St. Louis, MO, USA. FAU - Reddy, Priya AU - Reddy P AD - School of Medicine, St. Louis University, St. Louis, MO, USA. FAU - Nash, Maria AU - Nash M AD - School of Medicine, St. Louis University, St. Louis, MO, USA. FAU - Kohli, Nikita AU - Kohli N AD - School of Medicine, St. Louis University, St. Louis, MO, USA. FAU - Miyata, Shin AU - Miyata S AD - Department of Pediatric Surgery, SSM Health Cardinal Glennon Children's Hospital, 1465 S Grand Blvd, Saint Louis, MO, 63104, USA. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260727 PL - Germany TA - Surg Endosc JT - Surgical endoscopy JID - 8806653 SB - IM MH - *Appendectomy/statistics & numerical data MH - Humans MH - *Quality Improvement MH - Child MH - Postoperative Complications/epidemiology/etiology MH - Retrospective Studies MH - Risk Factors MH - *Research Design/standards MH - Surgical Wound Infection/epidemiology PMC - PMC13582071 OTO - NOTNLM OT - Acute appendicitis OT - Appendectomy OT - Missing data OT - Missingness OT - Pediatric surgery COIS- Declarations. Disclosures: Ayaka Tsutsumi, MD (Corresponding Author), Tong Si, PhD, Joanne Salas, MPH, Anna Hargrave, DO, Grace Trello, BS, Jessica Qiu, BS, Priya Reddy, BS, Maria Nash, BS, Nikita Kohli, BS, Shin Miyata, MD have no conflicts of interest or financial ties to disclose. EDAT- 2026/07/28 00:35 MHDA- 2026/09/17 05:35 PMCR- 2026/07/27 CRDT- 2026/07/27 23:30 PHST- 2026/03/18 00:00 [received] PHST- 2026/06/21 00:00 [accepted] PHST- 2026/09/17 05:35 [medline] PHST- 2026/07/28 00:35 [pubmed] PHST- 2026/07/27 23:30 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 10.1007/s00464-026-13123-7 [pii] AID - 13123 [pii] AID - 10.1007/s00464-026-13123-7 [doi] PST - ppublish SO - Surg Endosc. 2026 Sep;40(9):8068-8080. doi: 10.1007/s00464-026-13123-7. Epub 2026 Jul 27. PMID- 42509183 OWN - NLM STAT- Publisher LR - 20260727 IS - 1555-9823 (Electronic) IS - 0003-1348 (Linking) DP - 2026 Jul 27 TI - Vascular Preservation for Long-term Central Venous Access in Infants: The Facial Vein as an Underutilized Option. PG - 31348261462099 LID - 10.1177/00031348261462099 [doi] AB - Patients in the neonatal intensive care unit (NICU) may require long-term intravenous access for antibiotic administration, parenteral nutrition, resuscitation, and fluid support. In certain populations, particularly those with short bowel syndrome or with intestinal failure, preservation of vascular access is critical, as progressive loss of central venous access remains a major indication for intestinal transplantation and is associated with significant morbidity and mortality. The common facial vein has been sparsely described as an alternative route for central venous access and clinical data describing its outcomes and practical role remain limited. The primary aim of this study is to describe a single-center experience with tunneled facial vein catheter placement in neonates, focusing on feasibility, safety, and its role in emerging strategies directed towards vascular preservation. Data was obtained retrospectively from NICU patients who had a tunneled central venous catheter insertion between 2013 to 2019. A total of 72 upper body, tunneled central venous catheters were placed of which, 48 used the right or left facial vein as the access site, 13 were placed on the right or left internal jugular veins, and 11 of them were placed on the right or left subclavian vein. Evaluated outcomes included the incidence of intra/post operative hemorrhage, vagus nerve injury, cervical hematoma, palsy of mandibular branch of facial nerve, catheter blockage leading to re-operation, catheter infection, and operative time. Patients who had facial vein access were compared to the other upper body sites and the data was analyzed using a Pearson Chi-Squared test. There was no statistical significant difference regarding complications comparing facial vein access with the two aforementioned access sites. In addition, facial vein operative time was significantly shorter compared to internal jugular vein catheter placement. We propose tunneled facial vein catheterization represents a safe, practical, and underutilized option for neonatal central venous access. Its use may be exceptionally valuable in patients requiring long-term therapy in whom preservation of traditional access sites is essential. FAU - Ian, Gonzalez Montanez AU - Ian GM AUID- ORCID: 0009-0002-1237-8353 AD - University of Puerto Rico School of Medicine, San Juan, Puerto Rico. FAU - Juan, Cruz Lopez AU - Juan CL AUID- ORCID: 0009-0000-7096-1825 AD - University of Puerto Rico School of Medicine, San Juan, Puerto Rico. FAU - Paula, Ruiz Gil AU - Paula RG AD - Department of Surgery, University of Puerto Rico School of Medicine, San Juan, Puerto Rico. FAU - Monica, Roman AU - Monica R AUID- ORCID: 0009-0002-0736-7027 AD - Department of Surgery, University of Puerto Rico School of Medicine, San Juan, Puerto Rico. FAU - Jorge, Zequeira AU - Jorge Z AUID- ORCID: 0009-0002-7959-2653 AD - Department of Surgery, University of Puerto Rico School of Medicine, San Juan, Puerto Rico. LA - eng PT - Journal Article DEP - 20260727 PL - United States TA - Am Surg JT - The American surgeon JID - 0370522 SB - IM OTO - NOTNLM OT - facial vein OT - pediatric catheter OT - pediatric central venous access OT - pediatric vascular access failure OT - short bowel syndrome EDAT- 2026/07/28 00:35 MHDA- 2026/07/28 00:35 CRDT- 2026/07/27 22:03 PHST- 2026/07/28 00:35 [medline] PHST- 2026/07/28 00:35 [pubmed] PHST- 2026/07/27 22:03 [entrez] AID - 10.1177/00031348261462099 [doi] PST - aheadofprint SO - Am Surg. 2026 Jul 27:31348261462099. doi: 10.1177/00031348261462099. PMID- 42509057 OWN - NLM STAT- Publisher LR - 20260727 IS - 1878-1861 (Electronic) IS - 1878-1861 (Linking) DP - 2026 Jul 16 TI - Sports nutrition knowledge, beliefs, and dietary practices among African football players: a pan-African cross-sectional study. LID - S1440-2440(26)00287-2 [pii] LID - 10.1016/j.jsams.2026.07.010 [doi] AB - OBJECTIVES: This study assessed sports nutrition knowledge, nutrition-related beliefs, and dietary practices among African football players across all six Confederation of African Football zones and examined how age, sex, education, and competitive level relate to sports nutrition knowledge. DESIGN: Pan-African, descriptive cross-sectional study. METHODS: A total of 1310 players (758 men/boys; 552 women/girls) completed a validated questionnaire adapted from previous literature and the Nutrition for Sport Knowledge Questionnaire. Non-parametric tests (Mann-Whitney U; Kruskal-Wallis with Dunn-Holm correction), Chi-square tests, and Spearman correlations were used to examine group differences and associations. RESULTS: Overall, sports nutrition knowledge was low. Fewer than half of players correctly identified macronutrient content in common foods (carbohydrates 45-53%; protein 23-41%; fat 50-57%). Knowledge of optimal nutrient timing (34-39%) and hydration strategies (<33%) was similarly limited. Belief misconceptions were widespread: 75% endorsed routine supplement use, and nearly half believed iron tablets should be taken for fatigue and pallor. Only 8.5% reported high confidence in their sports nutrition knowledge, most of which originated from internet sources (34%). Although 68% consumed three meals daily, only 26-32% reported daily fruit or vegetable intake, while approximately 40% consumed daily fast food, sweetened beverages, and supplements. Sports nutrition knowledge differed significantly by age, education, and competition level (p < 0.001, respectively), with senior players and those with higher education scoring higher. Women/girls had higher sports nutrition knowledge than men/boys (p < 0.001). CONCLUSIONS: These findings highlight the need for context-specific, evidence-based nutrition education strategies to support healthy and performance-enhancing dietary behaviours among developing and elite football players across Africa. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Elghoul, Yousri AU - Elghoul Y AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Tunisia; Education, Motor Skills, Sports and Health (EM2S), LR19JS01, Tunisia; Union of North African Football (UNAF), Tunisia. FAU - Mwesigwa, Ben AU - Mwesigwa B AD - Council of East and Central Africa Football Association (CECAFA), Kenya; Federation of Uganda Football Associations (FUFA), Uganda. FAU - Douryang, Maurice AU - Douryang M AD - Department of Physiotherapy and Physical Medicine, University of Dschang, Cameroon; Central African Football Federations' Union (UNIFFAC), Gabon. FAU - Frimpong, Ralph AU - Frimpong R AD - Science Department, Abetifi Presbyterian College of Education, Ghana; Union of West African Federations - Zone B (WAFU-B), Cote d'Ivoire. FAU - Mahachi, Carol B AU - Mahachi CB AD - Department of Primary Health Care Sciences, University of Zimbabwe, Faculty of Medicine and Health Sciences, Zimbabwe; Biomedical Sciences Department, Great Zimbabwe University, Simon Mazorodze School of Medical and Health Sciences, Zimbabwe. FAU - Acquaye, Sidney-Rich AU - Acquaye SR AD - Confederation of African Football (CAF), Member Associations Division, Egypt. FAU - Mkumbuzi, Nonhlanhla S AU - Mkumbuzi NS AD - Confederation of African Football (CAF), Member Associations Division, Egypt; Department of Sports, Exercise, and Rehabilitation, Northumbria University, UK; NtombiSport (PTY) Ltd, South Africa. Electronic address: nonhlanhla.mkumbuzi@cafonline.com. LA - eng PT - Journal Article DEP - 20260716 PL - Australia TA - J Sci Med Sport JT - Journal of science and medicine in sport JID - 9812598 SB - IM OTO - NOTNLM OT - African football OT - Dietary habits OT - Elite OT - Nutrition information OT - Sports nutrition knowledge COIS- Declaration of interest statement The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: YE is a paid consultant for UNAF's Member Associations Division; BM is a paid consultant for CECAFA's Member Associations Division; MD is a paid consultant for UNIFFAC's Member Associations Division; RF is a paid consultant for WAFU-B's Member Associations Division; CBM has received payment from CAF for services; S-RA was an employee of CAF's Member Associations Division at the time of the study; NSM, is a paid consultant for CAF's Member Associations Division. EDAT- 2026/07/28 00:35 MHDA- 2026/07/28 00:35 CRDT- 2026/07/27 21:55 PHST- 2026/03/11 00:00 [received] PHST- 2026/07/09 00:00 [revised] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/07/28 00:35 [medline] PHST- 2026/07/28 00:35 [pubmed] PHST- 2026/07/27 21:55 [entrez] AID - S1440-2440(26)00287-2 [pii] AID - 10.1016/j.jsams.2026.07.010 [doi] PST - aheadofprint SO - J Sci Med Sport. 2026 Jul 16:S1440-2440(26)00287-2. doi: 10.1016/j.jsams.2026.07.010. PMID- 42508118 OWN - NLM STAT- MEDLINE DCOM- 20260906 LR - 20260906 IS - 1873-7072 (Electronic) IS - 0308-8146 (Linking) VI - 525 IP - Pt 3 DP - 2026 Oct 1 TI - Bridging analytical gaps in perchlorate monitoring: a comprehensive study of food contamination and exposure risk in Spain. PG - 150523 LID - S0308-8146(26)02683-X [pii] LID - 10.1016/j.foodchem.2026.150523 [doi] AB - Perchlorate is an emerging contaminant that can impair neurological development by disrupting thyroid function. Diet intake, particularly teas, fruits, and vegetables, is a major exposure pathway. This study developed a rapid, highly sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method applicable to all regulated food categories. The method's high sensitivity is essential, as it improves dietary exposure assessment and reduces uncertainties in risk evaluation, particularly for vulnerable populations. The method was validated with satisfactory recoveries (71-109%). A total of 115 food samples were analysed, including 28 infant food samples, a category notably underrepresented in European datasets. Perchlorate was detected in 95.7% of samples, with concentrations exceeding the European Union (EU) maximum limit in four cases. Risk assessment showed that infants and toddlers are especially vulnerable, with a Hazard Index, exceeding the safe limit of 1. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Ponz-Perello, Paula AU - Ponz-Perello P AD - Analytical Chemistry Department, University of Valencia, 19(th) Vicent Andres Estelles Av., 46100 Burjassot, Spain. FAU - Esteve-Turrillas, Francesc A AU - Esteve-Turrillas FA AD - Analytical Chemistry Department, University of Valencia, 19(th) Vicent Andres Estelles Av., 46100 Burjassot, Spain. FAU - Pardo, Olga AU - Pardo O AD - Analytical Chemistry Department, University of Valencia, 19(th) Vicent Andres Estelles Av., 46100 Burjassot, Spain. Electronic address: olga.pardo@uv.es. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20260722 PL - England TA - Food Chem JT - Food chemistry JID - 7702639 RN - 0 (Perchlorates) RN - VLA4NZX2P4 (perchlorate) SB - IM MH - *Perchlorates/analysis MH - *Food Contamination/analysis MH - Spain MH - Humans MH - *Tandem Mass Spectrometry/methods MH - Risk Assessment MH - *Dietary Exposure/analysis MH - Infant MH - *Liquid Chromatography-Mass Spectrometry/methods MH - Vegetables/chemistry OTO - NOTNLM OT - Contaminants OT - Dietary exposure OT - Infant population OT - Monitoring OT - Perchlorate OT - Risk assessment COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/27 18:35 MHDA- 2026/09/06 05:40 CRDT- 2026/07/27 17:59 PHST- 2026/01/07 00:00 [received] PHST- 2026/07/16 00:00 [revised] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/09/06 05:40 [medline] PHST- 2026/07/27 18:35 [pubmed] PHST- 2026/07/27 17:59 [entrez] AID - S0308-8146(26)02683-X [pii] AID - 10.1016/j.foodchem.2026.150523 [doi] PST - ppublish SO - Food Chem. 2026 Oct 1;525(Pt 3):150523. doi: 10.1016/j.foodchem.2026.150523. Epub 2026 Jul 22. PMID- 42507676 OWN - NLM STAT- MEDLINE DCOM- 20260727 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - An automated approach to extracting head and brain circumference from MRI datasets. PG - e0352445 LID - 10.1371/journal.pone.0352445 [doi] LID - e0352445 AB - Head circumference is a fundamental biometric parameter for brain growth in both the clinical pediatric setting and in developmental neuroscience. However, the gold standard for obtaining head circumference by manual tape measurement is notoriously error-prone. Further, while it is known that the growth trajectories of head and brain differ over time, a systematic comparison of these two parameters as a function of age does not yet exist. We developed a new and automated algorithm for obtaining head and brain circumference from MRI data. The algorithm mimics manual head circumference measurement by placing a convex hull around axial slices which must intersect with predefined anatomical landmarks. Several differently-tilted iterations are run and results are combined. In addition to obtaining head circumference, the approach can also be applied to gray matter only, providing "brain circumference" (gray matter hull perimeter) at the same level as head circumference. To assess validity, we used T1-weighted 3D datasets (n = 153) with available, manually measured head circumference values (age range 0-226 months [0-18.8 years]). To assess test-retest reliability, a second dataset (n = 3 with 40 scans each) was used. When compared with the current gold standard (manual measure), high validity was demonstrated for the new approach, with no systematic bias. The algorithm also showed a very high reliability across multiple measurements. Developmental trajectories of both head and brain circumference were generated and compared. In summary, the algorithm represents a valid and reliable method for the automated determination of head as well as brain circumference. It offers an objective way to assess these parameters in retrospect and prospectively, and may shed light on specific clinical situations where they differ, such as in the presence of enlarged subarachnoid spaces. CI - Copyright: (c) 2026 Klischat, Wilke. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Klischat, Jasmin AU - Klischat J AUID- ORCID: 0009-0008-1114-9122 AD - Department of Neuropediatrics, General Pediatrics, Diabetology, Endocrinology, Social Paediatrics, University Children's Hospital, Tubingen, Germany. AD - Experimental Pediatric Neuroimaging, Children's Hospital and Department of Neuroradiology, University of Tubingen, Germany. FAU - Wilke, Marko AU - Wilke M AUID- ORCID: 0000-0001-5655-027X AD - Department of Neuropediatrics, General Pediatrics, Diabetology, Endocrinology, Social Paediatrics, University Children's Hospital, Tubingen, Germany. AD - Experimental Pediatric Neuroimaging, Children's Hospital and Department of Neuroradiology, University of Tubingen, Germany. LA - eng PT - Journal Article DEP - 20260727 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Magnetic Resonance Imaging/methods MH - *Brain/anatomy & histology/growth & development MH - *Head/anatomy & histology MH - Algorithms MH - Child, Preschool MH - Child MH - Infant MH - Adolescent MH - Female MH - Infant, Newborn MH - Male MH - Reproducibility of Results MH - *Cephalometry/methods MH - Image Processing, Computer-Assisted/methods PMC - PMC13405294 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/27 18:35 MHDA- 2026/07/27 18:36 PMCR- 2026/07/27 CRDT- 2026/07/27 13:33 PHST- 2025/09/26 00:00 [received] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/07/27 18:36 [medline] PHST- 2026/07/27 18:35 [pubmed] PHST- 2026/07/27 13:33 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - PONE-D-25-51960 [pii] AID - 10.1371/journal.pone.0352445 [doi] PST - epublish SO - PLoS One. 2026 Jul 27;21(7):e0352445. doi: 10.1371/journal.pone.0352445. eCollection 2026. PMID- 42507667 OWN - NLM STAT- MEDLINE DCOM- 20260727 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - An evaluation of a breastfeeding peer support service in North East England: A qualitative study with service users, practitioners and volunteers. PG - e0354027 LID - 10.1371/journal.pone.0354027 [doi] LID - e0354027 AB - BACKGROUND: Breastfeeding has health benefits for women and infants. Although the WHO recommends that infants are breastfed exclusively for the first six months, exclusive breastfeeding rates remain low in the UK, with many women stopping breastfeeding within six weeks of their infant's birth. Many women face challenges initiating and continuing breastfeeding, including low confidence, limited support and misinformation. Breastfeeding peer support (BPS) services play a vital role in supporting women to continue to breastfeed by connecting new mothers with trained volunteers who offer advice, emotional encouragement and reliable information. METHODS: This study aimed to undertake a formative evaluation of the BPS service in Newcastle upon Tyne from the perspective of those who deliver the services, the wider healthcare team and mothers' experiences of utilising the service. This evaluation used a qualitative design, consisting of one-to-one semi-structured interviews with practitioners, volunteers, healthcare professionals and service users. Recruitment took place between 28th March - 14th May 2025. Recorded interview data were transcribed verbatim and analysed using Braun and Clarke's coding reliability thematic analysis. RESULTS: Twenty-two interviews were conducted (n = 11 practitioners, volunteers and healthcare professionals and n = 11 service users). Analysis identified four themes: mechanisms of the service; support offered by the service; outcomes of the service, and challenges to service delivery. Overall, the BPS was considered a supportive service by participants. CONCLUSIONS: The normalisation of breastfeeding was seen as crucial to the service, while service users described that the emotional support provided helped to increase their confidence in breastfeeding. Challenges were identified for the service, including engaging those aged under 25 years and those for whom English is a second language. These findings will be used to inform the future development of the service. CI - Copyright: (c) 2026 Brennan-Tovey et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Brennan-Tovey, Kerry AU - Brennan-Tovey K AUID- ORCID: 0000-0002-5516-6230 AD - Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. FAU - Barrett, Simon AU - Barrett S AUID- ORCID: 0000-0002-8216-2999 AD - Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. FAU - Hayes, Louise AU - Hayes L AD - Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. FAU - Moffat, Malcolm AU - Moffat M AD - Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. FAU - Nguyen, Gina AU - Nguyen G AD - Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. FAU - Aquino, Maria Raisa Jessica Ryc AU - Aquino MRJR AD - Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. FAU - Rankin, Judith AU - Rankin J AD - Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. LA - eng PT - Journal Article DEP - 20260727 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Breast Feeding/psychology MH - Female MH - *Peer Group MH - *Social Support MH - Adult MH - England MH - *Volunteers/psychology MH - Qualitative Research MH - Mothers/psychology MH - Infant MH - Health Personnel/psychology MH - Infant, Newborn PMC - PMC13405085 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/27 18:35 MHDA- 2026/07/27 18:36 PMCR- 2026/07/27 CRDT- 2026/07/27 13:33 PHST- 2026/02/09 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/07/27 18:36 [medline] PHST- 2026/07/27 18:35 [pubmed] PHST- 2026/07/27 13:33 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - PONE-D-26-06611 [pii] AID - 10.1371/journal.pone.0354027 [doi] PST - epublish SO - PLoS One. 2026 Jul 27;21(7):e0354027. doi: 10.1371/journal.pone.0354027. eCollection 2026. PMID- 42507462 OWN - NLM STAT- MEDLINE DCOM- 20261005 LR - 20261016 IS - 2168-6211 (Electronic) IS - 2168-6203 (Print) IS - 2168-6203 (Linking) VI - 180 IP - 10 DP - 2026 Oct 1 TI - Family-Centered Child Obesity Treatment: The TEAM UP Randomized Clinical Trial. PG - 1076-1084 LID - 10.1001/jamapediatrics.2026.3067 [doi] AB - IMPORTANCE: Families have limited access to pediatric weight management services. OBJECTIVE: To compare the effectiveness of enhanced standard of care (ESOC) with family-based behavioral treatment (FBT) vs ESOC alone in reducing percent over median body mass index (percent median BMI) among children and adolescents with obesity. ESOC+FBT was hypothesized to reduce relative weight more than would ESOC alone. DESIGN, SETTING, AND PARTICIPANTS: This was a pragmatic, comparative-effectiveness randomized clinical trial (2019-2024). Data collectors were blinded, and patients were followed up at 18 months. The setting included a total of 41 primary care clinical practices in Louisiana, New York, Missouri, and Illinois. Children and adolescents aged 6 to 15 years with obesity were referred by their primary care practitioner (PCP) or self-selected into the trial. INTERVENTIONS: ESOC was led by the PCP and intensified depending on a child's response. ESOC+FBT included all ESOC components plus meetings with an FBT interventionist, focusing on nutritious eating, physical activity, positive parenting strategies, and management of social and environmental cues. Both interventions lasted 12 months. MAIN OUTCOMES AND MEASURES: Change in percent median BMI at 12 months (end of treatment). RESULTS: A total of 1631 parents completed the web screen for their child, and 901 parent-child dyads were excluded or declined participation before randomization. The final sample of 730 children, each with a participating parent, had a mean (SD) age of 10.8 (2.5) years, 387 (54%) were female, 337 (47%) had Medicaid, and 160 (22%) had food insecurity. At the end of the treatment period, children in the group receiving ESOC+FBT experienced a significant reduction in percent median BMI (-6.4; 95% CI, -8.29 to -4.43) vs ESOC (-2.6; 95% CI, -4.46 to -0.71), with a mean between-group difference of -3.8 units (95% CI, -6.20 to -1.34 units; P = .002). Children's quality of life improved across both treatment arms at months 12 and 18. Similarly, weight-associated quality of life improved in both treatment arms, with greater improvements in ESOC+FBT at the end of the treatment period (6.8; 95% CI, 5.33-8.30 vs 4.8; 95% CI, 3.40-6.17; difference, 2.0 units; 95% CI, 0.05-4.00 units). There were no adverse events related to trial participation. CONCLUSIONS AND RELEVANCE: Results of this randomized clinical trial show that ESOC+FBT demonstrated a significantly larger reduction in child percent median BMI than did ESOC alone. These findings support the added value of incorporating FBT into pediatric primary care settings and its feasibility in reaching a geographically and socioeconomically diverse patient population. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT03843424. FAU - Staiano, Amanda E AU - Staiano AE AD - Pennington Biomedical Research Center, Baton Rouge, Louisiana. FAU - Cook, Stephen R AU - Cook SR AD - University of Rochester Medical Center, Rochester, New York. FAU - Stein, Richard I AU - Stein RI AD - Washington University in St. Louis, St. Louis, Missouri. FAU - Button, Alyssa M AU - Button AM AD - Pennington Biomedical Research Center, Baton Rouge, Louisiana. AD - Virginia Commonwealth University, Richmond. FAU - Newton, Robert L Jr AU - Newton RL Jr AD - Pennington Biomedical Research Center, Baton Rouge, Louisiana. FAU - Beyl, Robbie A AU - Beyl RA AD - Pennington Biomedical Research Center, Baton Rouge, Louisiana. FAU - Baker, Alison AU - Baker A AD - American Academy of Pediatrics, Itasca, Illinois. FAU - Lindros, Jeanne AU - Lindros J AD - American Academy of Pediatrics, Itasca, Illinois. FAU - Conn, Anne-Marie AU - Conn AM AD - University of Rochester Medical Center, Rochester, New York. FAU - Braddock, Amy S AU - Braddock AS AD - University of Missouri, Columbia. FAU - Welch, R Robinson AU - Welch RR AD - Washington University in St. Louis, St. Louis, Missouri. FAU - Wilfley, Denise E AU - Wilfley DE AD - Washington University in St. Louis, St. Louis, Missouri. CN - TEAM UP Research Group LA - eng SI - ClinicalTrials.gov/NCT03843424 PT - Journal Article PT - Multicenter Study PT - Pragmatic Clinical Trial PT - Randomized Controlled Trial PL - United States TA - JAMA Pediatr JT - JAMA pediatrics JID - 101589544 SB - IM EIN - JAMA Pediatr. 2026 Oct 1;180(10):1173. doi: 10.1001/jamapediatrics.2026.4806. PMID: 42832219 MH - Humans MH - Child MH - Female MH - Male MH - Adolescent MH - *Pediatric Obesity/therapy MH - *Behavior Therapy/methods MH - *Family Therapy/methods MH - Body Mass Index MH - Treatment Outcome PMC - PMC13409124 COIS- Conflict of Interest Disclosures: Dr Staiano reported receiving grants from Patient-Centered Outcomes Research Institute (PCORI), Louisiana Blue, Louisiana Healthcare Connections, and the National Institutes of Health (NIH) during the conduct of the study. Dr Cook reported receiving grants from PCORI during the conduct of the study. Dr Stein reported receiving grants from Washington University School of Medicine during the conduct of the study and grants from the NIH and Centers for Disease Control and Prevention (CDC) outside the submitted work. Dr Newton reported receiving grants from PCORI during the conduct of the study. Dr Beyl reported receiving grants from PCORI during the conduct of the study. Ms Baker reported receiving grants from PCORI during the conduct of the study. Ms Lindros reported receiving subcontracts from Public Health Institute, Massachusetts General Hospital, Veritas Management, Association of Diabetes Care and Education Specialists, and Vanderbilt University. Dr Wilfley reported receiving grants from PCORI during the conduct of the study; consulting fees from Novo Nordisk outside the submitted work; and serving as coinvestigator/eHealth-based treatment of adolescent obesity with low energy diet and semaglutide (eBATTLE Obesity [principal investigator, Joran Hjelmesaeth; funding body: The Norwegian Health Authority]), principal investigator (MPI)/Advancing Health Equity Through Community-Clinical Integration of Nutrition, Physical Activity, and Health Care in Historically Excluded Communities in the St. Louis Region (NCCDPHP 1NU58DP007643-01-00), principal investigator (MPI)/Increasing Access to US Preventive Services Task Force-Recommended Obesity Care for Youth and Adults Who Are Recipients of Medicaid: Evaluation of a Comprehensive Multidisciplinary Obesity Care Training Program in FQHCs, principal investigator (MPI)/Leveraging Interactive Digital Technology to Increase Access to Family-Based Behavioral Treatment for Childhood Obesity, and co-chief investigator/Bringing Fields Together: Identifying Individuals at Risk of Eating Disorders in Weight Management Program (The Australian National Health and Medical Research Council Ideas Grant). No other disclosures were reported. FIR - Fowler, Lauren IR - Fowler L FIR - Lima, Angela IR - Lima A FIR - McBride, Timothy IR - McBride T FIR - Stoll, Janis IR - Stoll J FIR - Capellan, Jahaira IR - Capellan J FIR - DiBitetto, Kristine IR - DiBitetto K FIR - Fiscella, Kevin IR - Fiscella K FIR - Williams, Geoffrey IR - Williams G FIR - Cherry, Lauren IR - Cherry L FIR - Drews, Kimberly IR - Drews K FIR - Gordon, Stewart IR - Gordon S FIR - Hall, Lindsay IR - Hall L FIR - Johnson, William IR - Johnson W FIR - Malek, Natalie IR - Malek N FIR - Murray, Peyton IR - Murray P FIR - Shao, Yaming IR - Shao Y FIR - Singletary, R Kenneth Jr IR - Singletary RK Jr FIR - Ullmer, Angelle IR - Ullmer A FIR - Zebrick, Ava IR - Zebrick A FIR - Hassink, Sandra IR - Hassink S FIR - Rogers, Victoria IR - Rogers V FIR - Salmon, Jeremiah IR - Salmon J EDAT- 2026/07/27 12:36 MHDA- 2026/10/05 17:31 PMCR- 2026/07/27 CRDT- 2026/07/27 11:35 PHST- 2026/10/05 17:31 [medline] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 11:35 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - 2851911 [pii] AID - poi260043 [pii] AID - 10.1001/jamapediatrics.2026.3067 [doi] PST - ppublish SO - JAMA Pediatr. 2026 Oct 1;180(10):1076-1084. doi: 10.1001/jamapediatrics.2026.3067. PMID- 42507042 OWN - NLM STAT- MEDLINE DCOM- 20260727 LR - 20261008 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 8 DP - 2026 Jul 27 TI - The spatial heterogeneity of intra-pancreatic fat deposition in children and adolescents with obesity. LID - 614 [pii] LID - 10.1007/s00431-026-07283-w [doi] AB - Childhood obesity is associated with an increased risk of metabolic associated fatty liver disease (MAFLD) and intra-pancreatic fat deposition (IPFD). Recent studies in adults suggest that pancreatic fat distribution is heterogeneous and that fat deposition in different regions may have distinct metabolic implications. However, data on regional IPFD patterns and their association with insulin resistance in children with obesity remain limited. This study aimed to investigate the regional distribution of pancreatic fat and its association with insulin resistance in children and adolescents with obesity. This retrospective study included 231 children and adolescents with obesity (156 boys, 75 girls; age range 8-18 years). All participants underwent magnetic resonance imaging (MRI) using the qDixon technique to quantify fat fractions in the pancreatic head, body, and tail, as well as in the liver. Insulin resistance was assessed using the homeostasis model assessment of insulin resistance (HOMA-IR). Statistical analyses included Spearman correlations, logistic regression, and receiver operating characteristic (ROC) curve analysis. The prevalence of high IPFD was higher in the pancreatic head than in the body and tail across all cutoff values (> 10%, > 15%, and > 20%) in both sexes (p < 0.01). Pancreatic head fat, but not body or tail fat, was significantly correlated with insulin levels and HOMA-IR (p < 0.01). In logistic regression models adjusted for confounders, pancreatic head fat (as a continuous variable and with a > 20% cutoff) was independently associated with high insulin (odds ratio (OR) = 1.02, 95% confidence interval (CI):1.002-1.043, and OR = 2.10, 95%CI: 1.00-4.47) and insulin resistance (OR = 1.02, 95% CI: 1.002-1.044; and OR = 2.31, 95% CI: 1.13-4.78, respectively). ROC analysis showed that pancreatic head fat had a significantly higher area under the curve (AUC = 0.65) for predicting insulin resistance than body, tail and liver fat (AUC = 0.60)(p = 0.02). In children and adolescents with obesity, the deposition of pancreatic fat is heterogeneous, with the greatest accumulation observed in the pancreatic head. Fat in the pancreatic head is independently associated with high insulin resistance, whereas fat in the body and tail is not. What is Known? * Obesity is associated with an increased risk of intra-pancreatic fat deposition (IPFD). * IPFD may be associated with metabolic risk. What is New? * This is the first study reporting the spatial heterogeneity of IPFD in children and adolescents with obesity. * Fat accumulation in the pancreatic head, but no in body and tail is associated with high level of insulin resistance. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Xiao, Hanfang AU - Xiao H AD - Department of Radiology, Shanghai Children's Hospital, Shanghai, 200062, China. AD - Department of Radiology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China. FAU - Zhang, Huanhuan AU - Zhang H AD - Department of Radiology, Shanghai Children's Hospital, Shanghai, 200062, China. AD - Department of Radiology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China. FAU - Yang, Hong AU - Yang H AD - Department of Radiology, Shanghai Children's Hospital, Shanghai, 200062, China. yanghongyh@sjtu.edu.cn. AD - Department of Radiology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China. yanghongyh@sjtu.edu.cn. FAU - Li, Tingting AU - Li T AD - Department of Radiology, Shanghai Children's Hospital, Shanghai, 200062, China. litt@shchildren.com.cn. AD - Department of Radiology, Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200062, China. litt@shchildren.com.cn. FAU - Chen, Xiao AU - Chen X AD - Department of Radiology, the Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China. LA - eng GR - k2026yrc25/Peak Talent Program of Jiangsu Provincial Hospital of Chinese Medicine/ PT - Journal Article DEP - 20260727 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Female MH - Male MH - Child MH - Adolescent MH - *Insulin Resistance MH - *Pancreas/diagnostic imaging/pathology MH - Retrospective Studies MH - Magnetic Resonance Imaging MH - *Pediatric Obesity/complications MH - *Adipose Tissue/diagnostic imaging MH - ROC Curve MH - Logistic Models OTO - NOTNLM OT - Children and adolescents OT - Intra-Pancreatic fat deposition OT - Obesity OT - Spatial heterogeneity COIS- Declarations. Ethical approval and consent to participate: Ethics approval was obtained from Shanghai Children Hospital. The study was performed in accordance with the Declaration of Helsinki. The need for informed consent was waived by the Ethics Committee of Shanghai Children Hospital because of the retrospective nature of the study. Consent for publication: Not applicable. Competing interest: The authors have no conflicts of interest to declare that are relevant to the content of this article. EDAT- 2026/07/27 12:36 MHDA- 2026/07/27 12:37 CRDT- 2026/07/27 11:05 PHST- 2026/04/15 00:00 [received] PHST- 2026/07/22 00:00 [accepted] PHST- 2026/07/20 00:00 [revised] PHST- 2026/07/27 12:37 [medline] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 11:05 [entrez] AID - 10.1007/s00431-026-07283-w [pii] AID - 10.1007/s00431-026-07283-w [doi] PST - epublish SO - Eur J Pediatr. 2026 Jul 27;185(8):614. doi: 10.1007/s00431-026-07283-w. PMID- 42506838 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260727 LR - 20260813 IS - 2075-4663 (Electronic) IS - 2075-4663 (Linking) VI - 14 IP - 7 DP - 2026 Jul 10 TI - Association Between Physical Activity and Mental Health in Primary School Children. LID - 10.3390/sports14070295 [doi] LID - 295 AB - Mental health during childhood is a major public health concern, and physical activity has been proposed as a modifiable behaviour associated with psychological well-being and emotional health. This study examined the associations between physical activity and mental health indicators, including psychological well-being, anxiety symptoms, and everyday stress, in primary school children. A cross-sectional study was conducted with 207 children from two schools in Jaen (Spain). Physical activity, psychological well-being, anxiety, and stress were assessed using validated questionnaires. Pearson correlations and multiple linear regression analyses adjusted for age, sex, and socioeconomic status were performed. Physical activity was positively associated with all dimensions of psychological well-being and with total psychological well-being (r = 0.182, p = 0.009). Significant inverse correlations were observed between physical activity and all anxiety dimensions, as well as total anxiety (r = -0.145, p = 0.037), although the association with total anxiety was not significant after adjustment (beta = -0.149, p = 0.112). Physical activity was also negatively associated with all stress dimensions and remained significantly associated with lower total stress after adjustment (beta = -0.253, p = 0.007). These findings indicate that higher levels of physical activity are associated with greater psychological well-being and lower everyday stress in primary school children. However, given the cross-sectional design, these associations should not be interpreted as causal relationships. Longitudinal studies are needed to clarify the directionality of these associations. FAU - Lendinez-Conejo, Raul AU - Lendinez-Conejo R AD - Faculty of Educational Sciences, University of Jaen, 23071 Jaen, Spain. FAU - Aibar-Almazan, Agustin AU - Aibar-Almazan A AUID- ORCID: 0000-0002-9386-9199 AD - Department of Health Sciences, Faculty of Health Sciences, University of Jaen, 35017 Jaen, Spain. FAU - Carcelen-Fraile, Maria Del Carmen AU - Carcelen-Fraile MDC AUID- ORCID: 0009-0000-9186-8865 AD - Department of Educational Sciences, Faculty of Social Sciences, University of Atlantico Medio, 35017 Las Palmas de Gran Canaria, Spain. AD - International Scientific Association on Innovation in Education and Health (ACIINES), 23007 Jaen, Spain. AD - International Network of Educational Law, 35017 Las Palmas de Gran Canaria, Spain. LA - eng PT - Journal Article DEP - 20260710 PL - Switzerland TA - Sports (Basel) JT - Sports (Basel, Switzerland) JID - 101722684 PMC - PMC13417498 OTO - NOTNLM OT - anxiety OT - childhood OT - physical activity OT - primary education OT - psychological well-being OT - stress COIS- The authors declare no conflicts of interest. EDAT- 2026/07/27 12:36 MHDA- 2026/07/27 12:37 PMCR- 2026/07/10 CRDT- 2026/07/27 09:44 PHST- 2026/06/06 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/07/27 12:37 [medline] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 09:44 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - sports14070295 [pii] AID - sports-14-00295 [pii] AID - 10.3390/sports14070295 [doi] PST - epublish SO - Sports (Basel). 2026 Jul 10;14(7):295. doi: 10.3390/sports14070295. PMID- 42506821 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260727 LR - 20260813 IS - 2075-4663 (Electronic) IS - 2075-4663 (Linking) VI - 14 IP - 7 DP - 2026 Jul 3 TI - High-Intensity Functional Concurrent Training for Physical Fitness, Body Composition, and Psychological Outcomes in Schoolchildren: Protocol for a Randomized Controlled Trial. LID - 10.3390/sports14070279 [doi] LID - 279 AB - High-intensity functional concurrent training (HIFCT) has emerged as a form of training characterized by constantly varied functional movements adapted to individual fitness levels. Previous studies have reported positive effects on muscular strength, cardiorespiratory fitness, body composition, and psychological well-being; however, evidence regarding HIFCT interventions in school-aged children remains limited. Therefore, the aim of the present study protocol is to evaluate the effects of an 8-week HIFCT programme on muscular strength, cardiorespiratory fitness, body composition, anxiety, stress, and self-esteem in children aged 10-12 years. Physical fitness, anthropometric variables, and psychological outcomes will be assessed before and after the intervention using validated field-based tests and questionnaires. This study may provide novel evidence regarding the feasibility, safety, and potential effects of HIFCT programmes in the school setting. The study protocol was registered at ClinicalTrials.gov (NCT07552844) and approved by the Cordoba Research Ethics Committee (IMIBIC, Cordoba, Spain; protocol code SICEIA-2025-000408). FAU - Duran-Lopez, Natalia AU - Duran-Lopez N AUID- ORCID: 0009-0008-5874-4519 AD - Ministry of Educational Development and Vocational Training, Regional Government of Andalusia, 41092 Sevilla, Spain. AD - Department of Psychology, Faculty of Educational Sciences and Psychology, University of Cordoba, 14004 Cordoba, Spain. FAU - Gomez-Garcia, Carlos AU - Gomez-Garcia C AUID- ORCID: 0009-0004-2735-2230 AD - Osuna University School, Teaching Center Attached to the University of Seville, 41640 Seville, Spain. FAU - Ranchal-Sanchez, Antonio AU - Ranchal-Sanchez A AUID- ORCID: 0000-0002-8655-8878 AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain. AD - Department of Nursing, Pharmacology and Physiotherapy, Faculty of Medicine and Nursing, University of Cordoba, 14004 Cordoba, Spain. FAU - Lucena-Jurado, Valentina AU - Lucena-Jurado V AUID- ORCID: 0000-0002-7011-6661 AD - Department of Psychology, Faculty of Educational Sciences and Psychology, University of Cordoba, 14004 Cordoba, Spain. FAU - Moyano-Ortega, Victoria AU - Moyano-Ortega V AD - Osuna University School, Teaching Center Attached to the University of Seville, 41640 Seville, Spain. FAU - Lara-Barahona Ostos, Ana AU - Lara-Barahona Ostos A AD - Osuna University School, Teaching Center Attached to the University of Seville, 41640 Seville, Spain. FAU - Jurado-Castro, Jose Manuel AU - Jurado-Castro JM AUID- ORCID: 0000-0002-0198-2793 AD - Osuna University School, Teaching Center Attached to the University of Seville, 41640 Seville, Spain. AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain. AD - CIBERobn Physiopathology of Obesity and Nutrition, Centre of Biomedical Research Network, Institute of Health Carlos III, 28029 Madrid, Spain. LA - eng SI - ClinicalTrials.gov/NCT07552844 GR - University of Cordoba OTC Transfer Contract No. 12021050/University of Cordoba/ PT - Journal Article DEP - 20260703 PL - Switzerland TA - Sports (Basel) JT - Sports (Basel, Switzerland) JID - 101722684 PMC - PMC13417676 OTO - NOTNLM OT - high-intensity functional concurrent training OT - physical fitness OT - psychological health OT - schoolchildren COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/07/27 12:36 MHDA- 2026/07/27 12:37 PMCR- 2026/07/03 CRDT- 2026/07/27 09:44 PHST- 2026/05/14 00:00 [received] PHST- 2026/06/26 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/07/27 12:37 [medline] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 09:44 [entrez] PHST- 2026/07/03 00:00 [pmc-release] AID - sports14070279 [pii] AID - sports-14-00279 [pii] AID - 10.3390/sports14070279 [doi] PST - epublish SO - Sports (Basel). 2026 Jul 3;14(7):279. doi: 10.3390/sports14070279. PMID- 42506391 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260727 LR - 20260813 IS - 2218-1989 (Print) IS - 2218-1989 (Electronic) IS - 2218-1989 (Linking) VI - 16 IP - 7 DP - 2026 Jun 23 TI - Metabolic Responses to Exercise and Nutritional Strategies in Type 1 Diabetes Using Automated Insulin Delivery Systems: A Narrative Review. LID - 10.3390/metabo16070437 [doi] LID - 437 AB - BACKGROUND/OBJECTIVES: Automated insulin delivery (AID) systems have improved the management of type 1 diabetes (T1D), but exercise and nutrition remain challenging because they rapidly alter glucose flux, substrate oxidation, hepatic glucose output, insulin requirements, and fuel availability. This narrative review aimed to synthesize current evidence on the interaction between AID systems, physical activity, and nutritional strategies from a metabolism-oriented perspective. METHODS: A narrative bibliographic approach was used to integrate evidence from clinical trials, observational studies, technical studies, consensus statements, and reviews involving people with T1D across different life stages, including pediatric, adolescent, adult, and pregnancy-related contexts, when available. The review focused on AID systems, exercise physiology, nutritional strategies, meal announcement, bolus adjustment, dual-hormone systems, metabolic biomarkers, and emerging metabolomic approaches. RESULTS: AID systems generally improve time in range and reduce hypoglycemia across several user groups, although most exercise- and nutrition-specific evidence comes from adult and pediatric/adolescent cohorts rather than pregnancy-specific exercise studies. Exercise-related glucose responses remain highly dependent on user input, exercise modality, insulin on board, meal timing, and metabolic state. Planned exercise announcement, prandial bolus reduction before postprandial activity, and individualized carbohydrate intake remain key strategies. Biomarkers such as lactate, ketone bodies, non-esterified fatty acids, and counter-regulatory hormones may help explain interindividual variability and support future personalization. CONCLUSIONS: Nutrition and exercise management in AID users should be interpreted as a dynamic metabolic interface among exogenous insulin, endogenous counter-regulation, substrate availability, and algorithmic control. Emerging approaches, including activity sensors, adaptive algorithms, dual-hormone systems, digital twins, and metabolomics-informed personalization, may improve safety and reduce user burden, but several remain exploratory and require further validation in diverse free-living conditions. FAU - Victoria-Montesinos, Desiree AU - Victoria-Montesinos D AUID- ORCID: 0000-0003-3968-9477 AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, 30107 Murcia, Spain. FAU - Llopis-Alonso, Inmaculada AU - Llopis-Alonso I AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, 30107 Murcia, Spain. FAU - Garcia-Munoz, Ana Maria AU - Garcia-Munoz AM AUID- ORCID: 0000-0002-1021-5385 AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, 30107 Murcia, Spain. FAU - Mercader-Ros, Maria Teresa AU - Mercader-Ros MT AUID- ORCID: 0000-0001-8194-0763 AD - Faculty of Pharmacy and Nutrition, UCAM Universidad Catolica de Murcia, 30107 Murcia, Spain. LA - eng PT - Journal Article PT - Review DEP - 20260623 PL - Switzerland TA - Metabolites JT - Metabolites JID - 101578790 PMC - PMC13413731 OTO - NOTNLM OT - artificial pancreas OT - automated insulin delivery OT - carbohydrate counting OT - continuous glucose monitoring OT - exercise metabolism OT - hybrid closed loop OT - metabolic biomarkers OT - metabolomics OT - nutrition OT - physical activity OT - type 1 diabetes COIS- The authors declare no conflicts of interest. EDAT- 2026/07/27 12:36 MHDA- 2026/07/27 12:37 PMCR- 2026/06/23 CRDT- 2026/07/27 09:34 PHST- 2026/05/15 00:00 [received] PHST- 2026/06/17 00:00 [revised] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/07/27 12:37 [medline] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 09:34 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - metabo16070437 [pii] AID - metabolites-16-00437 [pii] AID - 10.3390/metabo16070437 [doi] PST - epublish SO - Metabolites. 2026 Jun 23;16(7):437. doi: 10.3390/metabo16070437. PMID- 42506345 OWN - NLM STAT- MEDLINE DCOM- 20260727 LR - 20260813 IS - 2076-3271 (Electronic) IS - 2076-3271 (Linking) VI - 14 IP - 3 DP - 2026 Jul 6 TI - Emotional Eating and Its Associations with the Prevalence of Depression and Anxiety Symptoms in University Students: A Cross-Sectional Study. LID - 10.3390/medsci14030376 [doi] LID - 376 AB - Background/Objectives: Emotional eating (EE) is an emerging public health concern among university students, a population exposed to heightened academic demands, psychosocial stressors, and lifestyle changes that may promote maladaptive coping behaviors. EE has been linked to psychological distress, particularly depressive and anxiety symptoms, as well as sociodemographic, lifestyle, and anthropometric factors; however, findings remain heterogeneous and insufficiently integrated within comprehensive analytical frameworks. This study aimed to examine the association between EE and depressive and anxiety symptoms in university students, while assessing the independent contributions of sociodemographic, academic, lifestyle, and anthropometric determinants. Methods: A cross-sectional survey was performed among 1279 university students from 10 regions in Greece. Sociodemographic, academic, lifestyle, and anthropometric data were collected using validated instruments and standardized procedures. Depressive and anxiety symptoms were assessed by the use of the Beck Depression Inventory-II (BDI-II) and the six-item State-Trait Anxiety Inventory (STAI-6), respectively. EE was evaluated utilizing the EE subscale of the Three-Factor Eating Questionnaire-Revised 18 (TFEQ-R18). Multivariable ordinal logistic regression models were applied to examine independent associations. Results: In fully adjusted models, depressive and anxiety symptoms were the strongest correlates of higher EE levels, each associated with more than twofold increased odds. Female sex, Greek nationality, rural residence, enrollment in biomedical sciences, later academic years, and regular smoking were also positively associated with EE. Higher physical activity was inversely associated with EE levels. Overweight, obesity, and increased waist circumference and waist-to-hip ratio were consistently linked to higher EE, with several associations exceeding twofold increased odds. Conclusions: EE in university students is strongly associated with psychological distress and clusters with adverse lifestyle and anthropometric characteristics. These findings support the need for integrated interventions targeting mental health, lifestyle behaviors, and obesity-related risk factors. Longitudinal studies are warranted to clarify causal pathways and underlying mechanisms. FAU - Alexatou, Olga AU - Alexatou O AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Lemnos, Greece. FAU - Papadopoulou, Sousana K AU - Papadopoulou SK AUID- ORCID: 0000-0002-6408-6128 AD - Department of Nutritional Sciences and Dietetics, Faculty of Health Sciences, International Hellenic University, 57400 Thessaloniki, Greece. FAU - Angelakou, Exakousti-Petroula AU - Angelakou EP AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Lemnos, Greece. FAU - Migdanis, Athanasios AU - Migdanis A AD - Laboratory of Clinical Nutrition and Dietetics (CND-Lab), Department of Nutrition and Dietetics, University of Thessaly, 42132 Trikala, Greece. FAU - Louka, Aikaterini AU - Louka A AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Lemnos, Greece. FAU - Migdanis, Ioannis AU - Migdanis I AD - Faculty of Medicine, University of Thessaly, 41110 Larissa, Greece. AD - Oncology Clinic and Hemodialysis Unit, "E. Patsidis" Health Group, Department of Clinical Nutrition, 41335 Larissa, Greece. FAU - Mentzelou, Maria AU - Mentzelou M AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Lemnos, Greece. FAU - Koimtsidis, Theodosios AU - Koimtsidis T AD - Department of Nutritional Sciences and Dietetics, Faculty of Health Sciences, International Hellenic University, 57400 Thessaloniki, Greece. FAU - Psara, Evmorfia AU - Psara E AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Lemnos, Greece. FAU - Giaginis, Constantinos AU - Giaginis C AUID- ORCID: 0000-0003-2878-4831 AD - Department of Food Science and Nutrition, School of the Environment, University of the Aegean, 81400 Lemnos, Greece. LA - eng PT - Journal Article DEP - 20260706 PL - Switzerland TA - Med Sci (Basel) JT - Medical sciences (Basel, Switzerland) JID - 101629322 SB - IM MH - Humans MH - *Emotional Eating MH - Female MH - *Students/psychology MH - Cross-Sectional Studies MH - Universities MH - *Depression/epidemiology/psychology MH - Male MH - *Anxiety/epidemiology/psychology MH - Young Adult MH - Prevalence MH - Greece/epidemiology MH - Adult MH - Adolescent MH - Surveys and Questionnaires PMC - PMC13414101 OTO - NOTNLM OT - anxiety OT - depression OT - emotional eating OT - mental health OT - psychological distress OT - university students COIS- The authors declare no conflicts of interest. EDAT- 2026/07/27 12:36 MHDA- 2026/07/27 12:37 PMCR- 2026/07/06 CRDT- 2026/07/27 09:34 PHST- 2026/06/22 00:00 [received] PHST- 2026/06/29 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/07/27 12:37 [medline] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 09:34 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - medsci14030376 [pii] AID - medsci-14-00376 [pii] AID - 10.3390/medsci14030376 [doi] PST - epublish SO - Med Sci (Basel). 2026 Jul 6;14(3):376. doi: 10.3390/medsci14030376. PMID- 42505707 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260727 LR - 20260813 IS - 2304-6767 (Electronic) IS - 2304-6767 (Linking) VI - 14 IP - 7 DP - 2026 Jul 2 TI - Who Gets Dental Caries? A Comprehensive Review. LID - 10.3390/dj14070400 [doi] LID - 400 AB - Dental caries is the world's most common non-communicable disease with a complex etiology including social, behavioral, medical, biological and economical elements. The distribution among populations and age groups is skewed, which calls for validated clinical tools to identify those with increased caries risk. The aim of this article was therefore to review risk factors for caries development in children, based on global prospective birth cohorts, genetic proceedings and data from validated risk assessment tools. The genetic elements involve four main categories comprising enamel quality, salivary composition, dental biofilm function and taste preferences. Recent studies suggest that genes may account for 35-55% of the variation in caries scores in the young permanent dentition. Prospective birth cohorts have pointed out poverty, socioeconomic level, early introduction and excessive sugar intake as significant factors for a child's dental caries trajectory up into adulthood. Moreover, prolonged breastfeeding, child obesity and maternal oral conditions are linked to the caries burden later in life. In the clinic, the strongest predictors are past caries history and selected behavioral and social factors. The performance of the validated caries risk assessment models is far from perfect, but still acceptable in terms of reliability during childhood. These tools are the best clinical practice since they add objectivity, consistency and documentation to the clinical routines. In addition, the dental staff has the advantage of using the outcome of the assessment for a structured risk communication with the caregivers. The protocol should also form the basis for a personalized intervention program addressing the entire family, with particular focus on maternal oral health and sugar reduction. FAU - Twetman, Svante AU - Twetman S AUID- ORCID: 0000-0002-0199-9210 AD - Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark. AD - Department of Paediatric Dentistry, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Papaioannou, William AU - Papaioannou W AUID- ORCID: 0000-0001-5146-4399 AD - Department of Preventive and Community Dentistry, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Gizani, Sotiria AU - Gizani S AD - Department of Paediatric Dentistry, School of Dentistry, National and Kapodistrian University of Athens, 11527 Athens, Greece. LA - eng PT - Journal Article PT - Review DEP - 20260702 PL - Switzerland TA - Dent J (Basel) JT - Dentistry journal JID - 101716125 PMC - PMC13407877 OTO - NOTNLM OT - caries trajectory OT - children OT - heredity OT - risk assessment OT - socio-economy OT - sugars COIS- The authors have no conflicts of interest to declare. This paper was entirely financed by the authors' academic institutions. EDAT- 2026/07/27 12:36 MHDA- 2026/07/27 12:37 PMCR- 2026/07/02 CRDT- 2026/07/27 09:25 PHST- 2026/05/05 00:00 [received] PHST- 2026/06/23 00:00 [revised] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/07/27 12:37 [medline] PHST- 2026/07/27 12:36 [pubmed] PHST- 2026/07/27 09:25 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - dj14070400 [pii] AID - dentistry-14-00400 [pii] AID - 10.3390/dj14070400 [doi] PST - epublish SO - Dent J (Basel). 2026 Jul 2;14(7):400. doi: 10.3390/dj14070400. PMID- 42504412 OWN - NLM STAT- MEDLINE DCOM- 20260727 LR - 20260813 IS - 1099-0496 (Electronic) IS - 8755-6863 (Print) IS - 1099-0496 (Linking) VI - 61 IP - 8 DP - 2026 Aug TI - Functional Exercise Capacity and Exploratory ICF-Aligned Interpretation of the Incremental Shuttle Walk Test in Children With Asthma. PG - e71734 LID - 10.1002/ppul.71734 [doi] LID - e71734 AB - BACKGROUND: Children with asthma may experience functional exercise limitations that are not fully reflected by resting lung function or conventional clinical assessments. Field-based exercise tests provide complementary information regarding functional capacity, and the International Classification of Functioning, Disability and Health (ICF) offers a biopsychosocial framework to contextualize activity limitations. However, the integration of objective exercise performance with ICF-aligned interpretation in pediatric asthma remains limited. OBJECTIVE: To interpret functional exercise capacity in children with asthma using Incremental Shuttle Walk Test (ISWT) performance through an exploratory operational framework conceptually aligned with ICF activity qualifiers and to examine its association with lung function, asthma control, quality of life, and demographic characteristics. METHODS: In this cross-sectional study, 39 children with asthma (mean age 8.6 +/- 2.3 years) underwent spirometry, completed the Asthma Control Questionnaire (ACQ-6) and the Pediatric Asthma Quality of Life Questionnaire (PAQLQ), and performed the ISWT. Functional exercise capacity was expressed as a percentage of predicted ISWT distance and interpreted using an exploratory operational framework conceptually aligned with generic ICF activity qualifiers, generating two categories of activity limitation (mild/moderate and severe). RESULTS: Resting lung function was relatively preserved (mean FEV(1) 82.0 +/- 16.4% predicted), whereas functional exercise capacity was markedly reduced (mean ISWT 41.4 +/- 18.7% predicted). Based on the exploratory ICF-aligned framework, 72% of participants were categorized as having severe activity limitation. Children with severe limitations walked significantly shorter distances than those with mild/moderate limitations (32.0 +/- 11.5% vs. 65.3 +/- 10.1% predicted; p < 0.001), with a very large effect size. Spirometric indices, asthma control, and quality of life scores did not differ between functional categories. ISWT performance was not correlated with lung function, asthma control, or quality of life and demonstrated a negative association with age. CONCLUSION: Children with asthma may present substantial functional exercise limitations despite relatively preserved lung function and similar levels of asthma control and quality of life. The exploratory operational alignment of ISWT performance with generic ICF activity qualifiers may provide a clinically useful framework to support interpretation of activity limitations not captured by conventional assessments. However, this approach should be interpreted cautiously and requires future validation before broader clinical application. CI - (c) 2026 The Author(s). Pediatric Pulmonology published by Wiley Periodicals LLC. FAU - Cavalcante de Souza, Danilo Rufino AU - Cavalcante de Souza DR AD - Universidade de Sao Paulo - FMUSP, Sao Paulo, Brazil. FAU - Costa, Ivan Peres AU - Costa IP AD - Universidade Nove de Julho- UNINOVE, Sao Paulo, Brazil. FAU - Teixeira de Carvalho, Etiene Farah AU - Teixeira de Carvalho EF AUID- ORCID: 0000-0002-5765-7228 AD - Universidade Nove de Julho- UNINOVE, Sao Paulo, Brazil. FAU - Costa, Dirceu AU - Costa D AD - Universidade Nove de Julho- UNINOVE, Sao Paulo, Brazil. FAU - de Freitas Dantas Gomes, Evelim Leal AU - de Freitas Dantas Gomes EL AD - Universidade de Sao Paulo - FMUSP, Sao Paulo, Brazil. LA - eng PT - Journal Article PL - United States TA - Pediatr Pulmonol JT - Pediatric pulmonology JID - 8510590 SB - IM MH - Humans MH - Child MH - *Asthma/physiopathology MH - Female MH - Cross-Sectional Studies MH - Male MH - Quality of Life MH - *Exercise Tolerance/physiology MH - *Walk Test/methods MH - Spirometry MH - Surveys and Questionnaires MH - Adolescent MH - Disability Evaluation PMC - PMC13402909 OTO - NOTNLM OT - Incremental Shuttle Walk Test OT - International Classification of Functioning OT - activity limitation OT - functional exercise capacity OT - pediatric asthma COIS- The authors declare no conflicts of interest. EDAT- 2026/07/27 06:34 MHDA- 2026/07/27 06:35 PMCR- 2026/07/27 CRDT- 2026/07/27 03:43 PHST- 2026/05/11 00:00 [revised] PHST- 2026/01/05 00:00 [received] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/07/27 06:35 [medline] PHST- 2026/07/27 06:34 [pubmed] PHST- 2026/07/27 03:43 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - PPUL71734 [pii] AID - 10.1002/ppul.71734 [doi] PST - ppublish SO - Pediatr Pulmonol. 2026 Aug;61(8):e71734. doi: 10.1002/ppul.71734. PMID- 42504013 OWN - NLM STAT- MEDLINE DCOM- 20260727 LR - 20260813 IS - 1541-4337 (Electronic) IS - 1541-4337 (Linking) VI - 25 IP - 4 DP - 2026 Jul TI - Special Milk and Synthetic Biology: A Dual-Perspective Review of Ingredient Substitutions in Breast-Milk-Simulated Infant Formula. PG - e70572 LID - 10.1111/1541-4337.70572 [doi] LID - e70572 AB - Breast milk (BM) serves as the gold standard for infant nutrition, yet conventional cow's milk-based infant formulas (IF) fail to adequately replicate its structural and functional complexity. This review critically examines two complementary paradigms, specialty milk utilization and synthetic biology-enabled precision manufacturing, as transformative strategies for developing biomimetic IF ingredients. Specialty milks, including goat milk, camel milk, donkey milk, buffalo milk, and yak milk, exhibit compositional proximity to BM in specific dimensions, including digestibility, sn-2 fatty acid profiles, and fat globule size distribution. Synthetic biology platforms have achieved notable industrial-scale successes, particularly in producing 2'-fucosyllactose and recombinant lactoferrin. However, significant knowledge gaps persist: the reconstruction of complex multi-site phosphorylation, the high-fidelity assembly of triple-layer milk fat globule membranes, and cost-effective large-scale production remain unresolved challenges. Critically, most studies focus on single components rather than integrated formula systems, and robust clinical validation is lacking. This review argues that the convergence of specialty milk matrices with precision-fermented bioactives represents a paradigm shift from compositional to structure-function biomimicry. Priority research areas include multi-omics-based integration strategies, harmonized regulatory frameworks, and well-designed clinical trials to establish functional equivalence. Addressing these gaps will be essential for developing next-generation IF that more closely emulates the functional complexity of BM. CI - (c) 2026 Institute of Food Technologists(R). FAU - Zhang, Chao AU - Zhang C AD - State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang, China. AD - School of Food Science and Technology, Nanchang University, Nanchang, China. AD - Jiangxi Province Key Laboratory of Food Allergy, Nanchang, China. FAU - Qiu, Yu AU - Qiu Y AD - State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang, China. AD - School of Food Science and Technology, Nanchang University, Nanchang, China. AD - Jiangxi Province Key Laboratory of Food Allergy, Nanchang, China. FAU - Mao, Qingli AU - Mao Q AD - State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang, China. AD - School of Food Science and Technology, Nanchang University, Nanchang, China. AD - Jiangxi Province Key Laboratory of Food Allergy, Nanchang, China. FAU - Wu, Yong AU - Wu Y AUID- ORCID: 0000-0001-9840-940X AD - State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang, China. AD - Jiangxi Province Key Laboratory of Food Allergy, Nanchang, China. AD - Sino-German Joint Research Institute, Nanchang University, Nanchang, China. FAU - Meng, Xuanyi AU - Meng X AD - State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang, China. AD - Jiangxi Province Key Laboratory of Food Allergy, Nanchang, China. AD - Sino-German Joint Research Institute, Nanchang University, Nanchang, China. FAU - Zheng, Shuangyan AU - Zheng S AD - State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang, China. AD - Jiangxi Province Key Laboratory of Food Allergy, Nanchang, China. AD - Sino-German Joint Research Institute, Nanchang University, Nanchang, China. FAU - Chen, Hongbing AU - Chen H AUID- ORCID: 0000-0002-4845-383X AD - State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang, China. AD - Jiangxi Province Key Laboratory of Food Allergy, Nanchang, China. AD - Sino-German Joint Research Institute, Nanchang University, Nanchang, China. FAU - Li, Xin AU - Li X AUID- ORCID: 0000-0002-9466-2659 AD - State Key Laboratory of Food Science and Resource, Nanchang University, Nanchang, China. AD - School of Food Science and Technology, Nanchang University, Nanchang, China. AD - Jiangxi Province Key Laboratory of Food Allergy, Nanchang, China. LA - eng GR - 2026YFE0103600/National Key R&D Program of China/ PT - Journal Article PT - Review PL - United States TA - Compr Rev Food Sci Food Saf JT - Comprehensive reviews in food science and food safety JID - 101305205 SB - IM MH - Humans MH - *Infant Formula/chemistry MH - *Synthetic Biology MH - Animals MH - *Milk, Human/chemistry MH - *Milk/chemistry MH - Infant PMC - PMC13402779 OTO - NOTNLM OT - breast milk biomimicry OT - human milk oligosaccharides OT - infant formula OT - specialty milk OT - synthetic biology COIS- The authors declare no conflicts of interest. EDAT- 2026/07/27 06:34 MHDA- 2026/07/27 06:35 PMCR- 2026/07/27 CRDT- 2026/07/27 01:43 PHST- 2026/06/18 00:00 [revised] PHST- 2026/04/23 00:00 [received] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/07/27 06:35 [medline] PHST- 2026/07/27 06:34 [pubmed] PHST- 2026/07/27 01:43 [entrez] PHST- 2026/07/27 00:00 [pmc-release] AID - CRF370572 [pii] AID - 10.1111/1541-4337.70572 [doi] PST - ppublish SO - Compr Rev Food Sci Food Saf. 2026 Jul;25(4):e70572. doi: 10.1111/1541-4337.70572. PMID- 42502951 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260910 IS - 1099-1751 (Electronic) IS - 0749-6753 (Print) IS - 0749-6753 (Linking) VI - 41 IP - 5 DP - 2026 Sep TI - Understanding How Multisectoral Programs and Policies Across Systems Can Be Leveraged to Improve Maternal, Infant, and Child Nutrition in Guinea. PG - 1071-1084 LID - 10.1002/hpm.70105 [doi] AB - OBJECTIVE: To understand how current programmes and policies can be leveraged to improve maternal, infant, and young child nutrition outcomes (MIYCN) in Guinea. DATA COLLECTION METHODS: Study design. This study is part of a larger multiphase mixed methods study design. THEORETICAL FRAMEWORK: A systems framework developed by the United Nations Children's Fund (UNICEF) and an implementation science framework were used to guide this research. Phase 1. An in-depth literature review of current programme and policy documents (2019-2022) targeting MIYCN through the water, sanitation, and hygiene (WASH), health, food, and social protection systems in Guinea was conducted. Phase 2. Semi-structured interviews with stakeholders (n = 20) from each system were completed to explore stakeholders' knowledge related to pertinent programs and policies. Phase 3. Validation of findings was conducted using member checking. DATA ANALYSIS METHODS: Grey literature documents and interview findings were analysed using content analysis guided by the systems framework and implementation science framework, respectively. RESULTS: Policy documents across systems were all multisectoral and more than half (27/32) of evidence-based programme modalities across systems were included in policies. Most (28/32) evidence-based programme modalities were also being implemented in Guinea. Stakeholder interview findings revealed that programme implementation was the most salient barrier to operationalising evidence-based programme modalities. CONCLUSION: Findings from our study indicate that policy and programme frameworks are strong but improved financial planning and vertical and horizontal programme planning may create a stronger enabling environment to support MIYCN in Guinea. CI - (c) 2026 The Author(s). The International Journal of Health Planning and Management published by John Wiley & Sons Ltd. FAU - Schwendler, Teresa R AU - Schwendler TR AUID- ORCID: 0000-0002-0822-4880 AD - Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA. FAU - Sankhon, Ramatou Hermine AU - Sankhon RH AD - Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA. FAU - Jensen, Leif AU - Jensen L AD - Department of Agricultural Economics, Sociology, and Education, The Pennsylvania State University, University Park, Pennsylvania, USA. FAU - Fofana, Mohamed L AU - Fofana ML AD - Helen Keller Intl, Conakry, Guinea. FAU - Daffe, Mamady AU - Daffe M AD - Ministere de la Sante et de l'Hygiene Publique, Conakry, Guinea. FAU - Camara, Facely AU - Camara F AD - Ministere de la Sante et de l'Hygiene Publique, Conakry, Guinea. FAU - Zoma, Ramakwende AU - Zoma R AD - Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA. FAU - Balde, Ibrahima AU - Balde I AD - Centre de Recherche et de Formation en Infectiologie de Guinee, Conakry, Guinea. FAU - Kodish, Stephen R AU - Kodish SR AD - Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA. AD - Department of Biobehavioral Health, The Pennsylvania State University, State College, Pennsylvania, USA. LA - eng GR - Fulbright U.S. Student Program/ GR - Beard Program Endowment/ GR - Mary Frances Picciano Endowment Award/ GR - Nutritional Sciences Departmental Endowment Award/ GR - College of Health and Human Development Endowment Grant/ GR - Ann Atherton Hertzler Endowment/ PT - Journal Article PT - Review DEP - 20260726 PL - England TA - Int J Health Plann Manage JT - The International journal of health planning and management JID - 8605825 SB - IM MH - Humans MH - Guinea MH - Female MH - Infant MH - *Health Policy MH - Interviews as Topic MH - Child, Preschool PMC - PMC13551520 OTO - NOTNLM OT - infant and young child OT - nutrition OT - nutrition policy OT - pregnancy COIS- The authors declare no conflicts of interest. EDAT- 2026/07/26 13:21 MHDA- 2026/09/08 12:33 PMCR- 2026/09/08 CRDT- 2026/07/26 08:13 PHST- 2026/04/04 00:00 [revised] PHST- 2024/08/04 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/09/08 12:33 [medline] PHST- 2026/07/26 13:21 [pubmed] PHST- 2026/07/26 08:13 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - HPM70105 [pii] AID - 10.1002/hpm.70105 [doi] PST - ppublish SO - Int J Health Plann Manage. 2026 Sep;41(5):1071-1084. doi: 10.1002/hpm.70105. Epub 2026 Jul 26. PMID- 42502880 OWN - NLM STAT- MEDLINE DCOM- 20260929 LR - 20260929 IS - 1941-2452 (Electronic) IS - 0884-5336 (Linking) VI - 41 IP - 5 DP - 2026 Oct TI - Evaluation of the reliability of current neonatal malnutrition indicators in diagnosis: An analysis of a retrospective cohort. PG - 1445-1456 LID - 10.1002/ncp.70157 [doi] AB - BACKGROUND: Proposed diagnostic criteria for neonatal malnutrition have not been validated. The objective of this study was to evaluate the reliability of the 2018 neonatal malnutrition criteria for identifying malnutrition in preterm infants. METHODS: A retrospective study of premature infants admitted to a level III neonatal intensive care unit from 2013 to 2022 was performed. Malnutrition diagnoses were assigned using each indicator. Weight and linear growth velocities were defined using the preferred approach (maintaining z-score on Fenton growth chart) and generalized growth goals (weight: 15-20 g/kg/day for infants <2000 g, 20-30 g/day for infants >/=2000 g, length: 1 cm/week). Kappa (k) values assessed the inter-indicator reliability of the full criteria and the inter-indicator and intra-indicator reliability of individual malnutrition criteria. Acceptable reliability was defined as k > 0.8. RESULTS: This study included 2305 infants. The 2018 neonatal malnutrition criteria had poor inter-indicator reliability for diagnosis in the first 2 weeks of life (k = 0.054) and after the first 2 weeks (k = 0.087). Inter-indicator reliability varied but was better among growth-based indicators. Intra-indicator reliability was strong for weight gain velocity definitions (k values ranging from 0.86 to 0.94), but poor for linear growth definitions (k = 0.12). CONCLUSION: Proposed neonatal malnutrition criteria have poor reliability when all indicators are used and limited reliability at the individual indicator level. Utilization of generalized weight gain goals may be appropriate for malnutrition diagnosis, but the generalized linear growth goal of 1 cm/week is not. Differing patterns in malnutrition diagnoses should be investigated for clinical significance. Redevelopment of current indicators is likely warranted. CI - (c) 2026 American Society for Parenteral and Enteral Nutrition. FAU - Merlino Barr, Stephanie AU - Merlino Barr S AUID- ORCID: 0000-0002-0125-5684 AD - MetroHealth Medical Center, Cleveland, Ohio, USA. FAU - Hand, Rosa K AU - Hand RK AD - Case Western Reserve University, Cleveland, Ohio, USA. FAU - Collin, Marc AU - Collin M AD - MetroHealth Medical Center, Cleveland, Ohio, USA. FAU - Love, Thomas E AU - Love TE AD - MetroHealth Medical Center, Cleveland, Ohio, USA. AD - Case Western Reserve University, Cleveland, Ohio, USA. FAU - Groh-Wargo, Sharon AU - Groh-Wargo S AD - MetroHealth Medical Center, Cleveland, Ohio, USA. AD - Case Western Reserve University, Cleveland, Ohio, USA. LA - eng GR - Stephanie Merlino Barr has received compensation for creating and presenting academic materials for Abbott Nutrition Health Institute, Reckitt/Mead Johnson, and Nutricia. Dr. Groh-Wargo is on the speaker's bureau of Abbott Nutrition. Drs. Hand, Collin, and Love have no financial disclosures/ PT - Evaluation Study PT - Journal Article DEP - 20260726 PL - United States TA - Nutr Clin Pract JT - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JID - 8606733 SB - IM MH - Humans MH - Retrospective Studies MH - Infant, Newborn MH - Reproducibility of Results MH - *Infant Nutrition Disorders/diagnosis MH - Female MH - Infant, Premature/growth & development MH - Male MH - Intensive Care Units, Neonatal MH - *Nutrition Assessment OTO - NOTNLM OT - malnutrition OT - neonatal OT - premature infants OT - reliability OT - weight gain EDAT- 2026/07/26 06:42 MHDA- 2026/09/29 12:27 CRDT- 2026/07/26 04:12 PHST- 2026/06/04 00:00 [revised] PHST- 2025/09/22 00:00 [received] PHST- 2026/06/20 00:00 [accepted] PHST- 2026/09/29 12:27 [medline] PHST- 2026/07/26 06:42 [pubmed] PHST- 2026/07/26 04:12 [entrez] AID - 10.1002/ncp.70157 [doi] PST - ppublish SO - Nutr Clin Pract. 2026 Oct;41(5):1445-1456. doi: 10.1002/ncp.70157. Epub 2026 Jul 26. PMID- 42502626 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260726 LR - 20260813 IS - 1728-869X (Print) IS - 2226-5104 (Electronic) IS - 1728-869X (Linking) VI - 24 IP - 4 DP - 2026 Oct TI - A school-level randomized preliminary study of in-classroom physical activity breaks among fifth graders. PG - 200498 LID - 10.1016/j.jesf.2026.200498 [doi] LID - 200498 AB - BACKGROUND: In-classroom physical activity breaks (IcPABs) are a pragmatic strategy to reduce sedentary time and promote movement during instructional lessons. However, evidence from primary schools operating within a high-stakes examination-focused education system, where academic achievement in national assessments is prioritized in classroom instruction is limited from low- and middle-income countries. This study aimed to examine the preliminary effects and feasibility of a teacher-led, in-classroom physical activity break intervention on school-time movement behaviors, academic performance, and selected health-related outcomes among Sri Lankan fifth-grade students. METHODS: 220 students from two government primary schools in Sri Lanka (mean (age) = 9.48 years +/- 0.5, 61% male) were randomly assigned to (1) an intervention group (n = 100): attending thrice-a-day, 5-min IcPAB for 12 weeks; and (2) a control group (n = 120). Pre- and post-intervention assessments were conducted for academic achievement (standardized tests), movement behaviors (ActiGraph Gt3X), body-mass-index (anthropometric data), aerobic fitness (20m shuttle run test), and perceived stress (PSQ8-11). Generalized Linear Mixed Models were used for statistical analyses at exploratory level. Feasibility was evaluated using teacher logs, classroom observations and process evaluation records. RESULTS: Significant group-by-time effects were observed for reading performance (82.2 +/- 13.9 to 88.0 +/- 12.9 vs 76.7 +/- 10.5 to 77.6 +/- 13.0 in controls), MVPA (27.2 +/- 9.4 to 44.3 +/- 9.9 vs 31.1 +/- 8.4 to 24.3 +/- 9.4), step count (5609 +/- 1019 to 7769 +/- 1339 vs 7998 +/- 1023 to 3942 +/- 1046), and sedentary school time (1490.7 +/- 53.1 to 1475.4 +/- 59.4 vs 1485.0 +/- 22.9 to 1655.1 +/- 40.8). The study fidelity assessment confirmed 1 to 4 times daily activity implementation. The process evaluation indicated satisfactory participant engagement and smooth implementation, suggesting the study was conducted as intended. CONCLUSION: This school level randomized preliminary study observed improvements in reading performance, while effects on mathematics and health-related outcomes were limited. However, in-classroom physical activity breaks were feasible to implement in an academically intensive Sri Lankan primary school context and were associated with favorable changes in school-time movement behaviors. Yet larger multi-school trials are expected to confirm these findings. CI - (c) 2026 The Society of Chinese Scholars on Exercise Physiology and Fitness. Published by Elsevier B.V. FAU - Duan, Yanping AU - Duan Y AD - Department of Sports and Health Sciences, Hong Kong Baptist University, Hong Kong Special Administrative Region of China. FAU - Peiris, D L I H K AU - Peiris DLIHK AD - Department of Sport Science and Physical Education, University of Kelaniya, Sri Lanka. FAU - Vandelanotte, Corneel AU - Vandelanotte C AD - Physical Activity Research Group, Central Queensland University, Australia. FAU - Liang, Wei AU - Liang W AD - School of Physical Education, Shenzhen University, China. LA - eng PT - Journal Article DEP - 20260713 PL - Singapore TA - J Exerc Sci Fit JT - Journal of exercise science and fitness JID - 101198241 PMC - PMC13400259 OTO - NOTNLM OT - Accelerometers OT - BCT OT - COM-B model OT - Pre-adolescents OT - Seated learning COIS- The authors declare that they have no competing interests. EDAT- 2026/07/26 06:42 MHDA- 2026/07/26 06:43 PMCR- 2026/07/13 CRDT- 2026/07/26 04:07 PHST- 2026/02/09 00:00 [received] PHST- 2026/06/21 00:00 [revised] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/26 06:43 [medline] PHST- 2026/07/26 06:42 [pubmed] PHST- 2026/07/26 04:07 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - S1728-869X(26)00059-6 [pii] AID - 200498 [pii] AID - 10.1016/j.jesf.2026.200498 [doi] PST - ppublish SO - J Exerc Sci Fit. 2026 Oct;24(4):200498. doi: 10.1016/j.jesf.2026.200498. Epub 2026 Jul 13. PMID- 42502158 OWN - NLM STAT- MEDLINE DCOM- 20260725 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 24 TI - Study protocol for Full Speed Ahead: an intervention for improved activities in daily life through Frame Running and Goal directed training. LID - 10.1186/s12887-026-07318-z [doi] LID - 684 AB - BACKGROUND: Early and intensive intervention is crucial for children with cerebral palsy (CP), particularly during the period when gross motor activities typically develop. Despite the prevalence of CP, robust evidence for effective early mobility interventions remains limited. Frame Running, which enables children with limited walking ability to engage in dynamic, high-intensity activities, has emerged as a promising approach, yet research on its effect in young children is currently lacking. The aim of this study is to implement and evaluate the effects of a mobility-focused training program combining Frame Running and goal-directed gross motor training, on mobility in every day life and cardiovascular health in children aged 2-5 years with CP. METHOD: The study uses a prospective repeated-measures intervention design with assessments conducted during baseline, intervention, and post-intervention follow-up phases. At least 18 children meeting the inclusion criteria (CP diagnosis, age 2-5 years, GMFCS II-IV) will participate. The design consists of three baseline measurements, a 12-week intervention phase and three post-intervention measurements, across approximately 5-6 months. The program combines home-based training and hospital-based group training, with parents as active trainers and therapists providing coaching. Frame Running and goal-directed training are tailored to individual goals, set collaboratively with families. Outcome measures include the Gross Motor Function Measure (GMFM-66), Functional Mobility Scale (FMS), Paediatric Evaluation of Disability Inventory Computerised Assessment Test (PEDI-CAT), time-based mobility tests: ultrasound assessment of muscle size and morphology, gait analysis, accelerometry (7-day activity monitoring), heart rate monitoring during training, and Goal Attainment Scaling (GAS). Feasibility and fidelity will be investigated by questionnaires. DISCUSSION: By evaluating the Full Speed Ahead program, this study aims to improve understanding of how an early intensive family-centered mobility intervention may influence developmental trajectories and health in children with CP. If effective, the findings will have significant implications for planning both short- and long-term treatment and services for young children with CP. The prospective repeated-measures intervention design allows for both group-level and individual-level analysis of changes over time, thereby strengthening the evidence base for early, intensive, family-centered mobility interventions. TRIAL REGISTRATION: ClinicalTrial.gov NCTO7374432, Registered November 18 2025. CI - (c) 2026. The Author(s). FAU - Eliasson, Ann-Christin AU - Eliasson AC AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. ann-christin.eliasson@ki.se. AD - Astrid Lindgren's Children Hospital, Karolinska University Hospital, Stockholm, Sweden. ann-christin.eliasson@ki.se. FAU - Lowing, Kristina AU - Lowing K AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Medical Unit Allied Health Professional, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden. FAU - Hjalmarsson, Emma AU - Hjalmarsson E AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Medical Unit Allied Health Professional, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden. FAU - Lidbeck, Cecilia AU - Lidbeck C AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Astrid Lindgren's Children Hospital, Karolinska University Hospital, Stockholm, Sweden. FAU - Adestedt, Agnes AU - Adestedt A AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Medical Unit Allied Health Professional, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden. FAU - Starck, Julia AU - Starck J AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. FAU - Aspdahl, Magnus AU - Aspdahl M AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Medical Unit Allied Health Professional, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden. FAU - Lowing, Josefin AU - Lowing J AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Medical Unit Allied Health Professional, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden. FAU - Frisk, Emelie AU - Frisk E AD - Medical Unit Allied Health Professional, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden. FAU - Strand, Johanna AU - Strand J AD - Medical Unit Allied Health Professional, Theme Women's Health and Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden. FAU - Ericson, Annika AU - Ericson A AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Astrid Lindgren's Children Hospital, Karolinska University Hospital, Stockholm, Sweden. FAU - Andersson, Kristina AU - Andersson K AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. FAU - Brostrom, Eva AU - Brostrom E AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Astrid Lindgren's Children Hospital, Karolinska University Hospital, Stockholm, Sweden. FAU - Kvist, Ola AU - Kvist O AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Department of Radiology, Columbia University, New York, USA. FAU - Norrbom, Jessica AU - Norrbom J AD - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. FAU - von Walden, Ferdinand AU - von Walden F AD - Neuropediatric Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, 171 76, Sweden. AD - Astrid Lindgren's Children Hospital, Karolinska University Hospital, Stockholm, Sweden. LA - eng SI - ClinicalTrials.gov/2024-05809-01, Registered November 18 2025 PT - Journal Article DEP - 20260724 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Child, Preschool MH - *Cerebral Palsy/rehabilitation/physiopathology MH - Prospective Studies MH - *Running MH - *Activities of Daily Living MH - *Exercise Therapy/methods MH - Goals MH - Male MH - Female PMC - PMC13401323 OTO - NOTNLM OT - Cerebral palsy OT - Early intervention OT - Gait OT - Goal directed training and Frame running OT - Mobility OT - Muscle OT - Physical activity OT - Walking COIS- Declarations. Ethics approval and consent to participate: Full ethical approval for this study has been obtained from the Swedish Ethical Review Authority (Dnr 2024-05809-01). All parents will be given oral and written information about the study before being asked to sign an informed consent form. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/26 00:42 MHDA- 2026/07/26 00:43 PMCR- 2026/07/24 CRDT- 2026/07/25 23:23 PHST- 2025/12/10 00:00 [received] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/07/26 00:43 [medline] PHST- 2026/07/26 00:42 [pubmed] PHST- 2026/07/25 23:23 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - 10.1186/s12887-026-07318-z [pii] AID - 7318 [pii] AID - 10.1186/s12887-026-07318-z [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 24;26(1):684. doi: 10.1186/s12887-026-07318-z. PMID- 42501948 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260916 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 124 IP - 3 DP - 2026 Sep TI - The validity of measuring energy and nutrient intake with the Remote Food Photography Method (RFPM) in adolescents. PG - 101452 LID - S0002-9165(26)00261-3 [pii] LID - 10.1016/j.ajcnut.2026.101452 [doi] AB - BACKGROUND: The remote food photography method (RFPM) accurately estimates energy intake (EI) in adults, but its validity in adolescents has yet to be tested. Given the low accuracy of self-reported dietary intake in adolescents, evaluating the validity of the RFPM in both controlled and free-living settings is crucial. OBJECTIVES: To examine the validity of the RFPM in estimating adolescents' EI in controlled and free-living settings. METHODS: In Study 1, adolescents (n = 45) used the RFPM/SmartIntake application during 1) a laboratory test meal, 2) a cafeteria meal, and 3) 7 d of free-living intake, with EI estimations validated against weighed food intake, digital photography of foods method, and doubly labeled water, respectively. EI was measured under the same 3 settings with pen-and-paper food records. After refining the application and training, Study 2 (n = 22) repeated the protocol with a 3-d free-living period. For both studies, equivalence was evaluated using two one-sided t-tests (+/-10% bounds), and linear mixed models assessed RFPM error by participant characteristics. RESULTS: In Study 1, RFPM estimates of EI were equivalent to the criterion measure during cafeteria meals [mean standard deviation (SD) error: 4.1 (120.8) kcal; P = 0.005] but were not equivalent for the laboratory test meal [mean (SD) error: 61.1 (112.7) kcal; P = 0.675] and 7 d of free-living intake [mean (SD) error: -887.9 (554.8) kcal/d; P > 0.99]. In Study 2, RFPM EI estimates were equivalent to the criterion measure in the controlled setting [mean (SD) error: -2.2 (86.5) kcal; P = 0.007], but not in free-living settings [mean (SD) error: -782.8 (947.0) kcal/d; P = 0.99]. In both studies, a higher body mass index (in kg/m(2)) percentile was associated with greater underestimation of EI (both R(2) > 0.19 and P < 0.05). CONCLUSIONS: The RFPM can accurately estimate the meal-level EI of adolescents in controlled settings; however, significant underestimation occurred in free-living settings in both studies. Previous studies demonstrated the inability to accurately assess adolescents' free-living intake, and the current results extend these findings to the RFPM. This trial was registered at clinicaltrials.gov as Study 1: NCT01719445 (https://clinicaltrials.gov/study/NCT01719445) and Study 2: NCT04148560 (https://clinicaltrials.gov/study/NCT04148560). CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Hochsmann, Christoph AU - Hochsmann C AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States; Department of Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Diktas, Hanim E AU - Diktas HE AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Myers, Candice A AU - Myers CA AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Dorling, James L AU - Dorling JL AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States; Human Nutrition, School of Medicine, Dentistry and Nursing, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom. FAU - Rood, Jennifer C AU - Rood JC AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Greenway, Frank AU - Greenway F AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Champagne, Catherine M AU - Champagne CM AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Apolzan, John W AU - Apolzan JW AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Martin, Corby K AU - Martin CK AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. Electronic address: corby.martin@pbrc.edu. LA - eng SI - ClinicalTrials.gov/NCT04148560 SI - ClinicalTrials.gov/NCT01719445 GR - R01 DK089051/DK/NIDDK NIH HHS/United States GR - F32 HD116537/HD/NICHD NIH HHS/United States GR - P30 DK072476/DK/NIDDK NIH HHS/United States GR - T32 DK064584/DK/NIDDK NIH HHS/United States GR - U54 GM104940/GM/NIGMS NIH HHS/United States PT - Clinical Trial PT - Journal Article PT - Validation Study DEP - 20260725 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - Diet Records MH - *Energy Intake MH - Nutrition Assessment MH - *Photography/methods MH - Reproducibility of Results PMC - PMC13573646 MID - NIHMS2206243 OTO - NOTNLM OT - RFPM OT - adolescents OT - dietary assessment OT - doubly labeled water OT - energy intake OT - remote food photography method COIS- Conflict of interest The intellectual property surrounding the remote food photography method and SmartIntake application is owned by Louisiana State University/Pennington Biomedical, and CKM is an inventor of the technology and is employed by Louisiana State University/Pennington Biomedical. All other authors report no conflicts of interest. EDAT- 2026/07/26 00:42 MHDA- 2026/09/01 23:34 PMCR- 2026/09/14 CRDT- 2026/07/25 19:13 PHST- 2026/03/18 00:00 [received] PHST- 2026/06/24 00:00 [revised] PHST- 2026/07/21 00:00 [accepted] PHST- 2026/09/01 23:34 [medline] PHST- 2026/07/26 00:42 [pubmed] PHST- 2026/07/25 19:13 [entrez] PHST- 2026/09/14 00:00 [pmc-release] AID - S0002-9165(26)00261-3 [pii] AID - 10.1016/j.ajcnut.2026.101452 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Sep;124(3):101452. doi: 10.1016/j.ajcnut.2026.101452. Epub 2026 Jul 25. PMID- 42501820 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260923 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 75 DP - 2026 Oct TI - Genetically predicted breastfeeding propensity and brain microstructural morphology: Insights from genome-wide association study summary statistics and neurogenomics. PG - 103612 LID - S2405-4577(26)00709-6 [pii] LID - 10.1016/j.clnesp.2026.103612 [doi] AB - BACKGROUND: Breastfeeding provides nutrients and bioactive components relevant to infant development, but observational associations with brain outcomes may be influenced by socioeconomic, maternal, and family-level factors. Mendelian randomization (MR) offers a genetic framework for evaluating associations by using genetic variants as proxies for breastfeeding propensity; it does not directly measure the effect of actual breastfeeding behavior. OBJECTIVES: This study investigated associations between genetically predicted breastfeeding propensity and brain imaging-derived phenotypes (IDPs). METHODS: We performed a two-sample MR analysis using genome-wide association study (GWAS) summary statistics from 352,094 European participants. Genetically predicted breastfeeding propensity served as the exposure, and 393 brain IDPs from the UK Biobank served as outcomes. Double Machine Learning (DML), using random forest models and 5-fold cross-fitting, was applied as a complementary validation approach. Heterogeneity and pleiotropy analyses were conducted to assess the robustness of the instrumental-variable estimates. RESULTS: At the nominal significance level, positive MR estimates were observed between genetically predicted breastfeeding propensity and the left anterior thalamic radiation fractional anisotropy measure (IDP dMRI ProbtrackX FA atr l: Beta = 2.787, p = 0.045), the right lingual area (Beta = 2.032, p = 0.022), and the right superior temporal area (Beta = 1.719, p = 0.011). Inverse estimates were observed for measures including left mean cortical thickness (Beta = -2.266, p = 0.014). DML provided complementary evidence for associations involving the subcallosal gyrus and precentral thickness. Statistical power exceeded 80% for the primary outcomes; however, nominal findings that did not meet the Bonferroni threshold should be considered exploratory. CONCLUSIONS: This study provides genetic evidence of region-specific associations between genetically predicted breastfeeding propensity and brain structural phenotypes, including an association with higher fractional anisotropy in the left anterior thalamic radiation. Associations involving regions implicated in language, visual processing, and cortical maturation do not establish corresponding cognitive or functional effects. The findings are hypothesis-generating and require replication in independent and longitudinal datasets before direct behavioral or public health implications can be inferred. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Peng, Wan AU - Peng W AD - The Second Affiliated Hospital of Guangdong Medical University, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, China. FAU - Zheng, Lu AU - Zheng L AD - Department of Nursing and Pediatrics, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. FAU - Huo, Fengjing AU - Huo F AD - The Second Affiliated Hospital of Guangdong Medical University, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, China. FAU - Gong, Huiting AU - Gong H AD - The Second Affiliated Hospital of Guangdong Medical University, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, China. FAU - Zhang, Ming AU - Zhang M AD - Department of Physical Medicine and Rehabilitation, Zibo Central Hospital, Zibo, China. Electronic address: signname@163.com. FAU - Zhu, Xiao AU - Zhu X AD - The Second Affiliated Hospital of Guangdong Medical University, School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang, China. Electronic address: xzhu@gdmu.edu.cn. LA - eng PT - Journal Article DEP - 20260725 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM MH - Humans MH - *Genome-Wide Association Study MH - *Brain/diagnostic imaging/anatomy & histology MH - *Breast Feeding MH - Female MH - Mendelian Randomization Analysis MH - Phenotype MH - Magnetic Resonance Imaging MH - UK Biobank MH - Polymorphism, Single Nucleotide MH - Male MH - United Kingdom MH - Machine Learning OTO - NOTNLM OT - Brain imaging-derived phenotypes OT - Breastfeeding OT - Double machine learning OT - Mendelian randomization OT - Neurodevelopment COIS- Competing interests The authors declare that they have no competing interests. EDAT- 2026/07/26 00:42 MHDA- 2026/09/23 05:34 CRDT- 2026/07/25 19:12 PHST- 2026/05/07 00:00 [received] PHST- 2026/07/16 00:00 [revised] PHST- 2026/07/18 00:00 [accepted] PHST- 2026/09/23 05:34 [medline] PHST- 2026/07/26 00:42 [pubmed] PHST- 2026/07/25 19:12 [entrez] AID - S2405-4577(26)00709-6 [pii] AID - 10.1016/j.clnesp.2026.103612 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2026 Oct;75:103612. doi: 10.1016/j.clnesp.2026.103612. Epub 2026 Jul 25. PMID- 42500983 OWN - NLM STAT- Publisher LR - 20260725 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 Jul 25 TI - Comparative assessment of preterm infant feeding strategies in government versus private neonatal intensive care units in Pakistan: A cross-sectional study. PG - 2601060261471951 LID - 10.1177/02601060261471951 [doi] AB - BackgroundEarly and adequate nutritional support in neonatal intensive care units (NICUs) is essential for reducing complications and mortality among preterm infants. Despite established guidelines, variations in feeding practices persist across healthcare settings.AimTo evaluate preterm feeding practices across NICUs in Pakistan and compare feeding strategies between government and private hospitals.MethodsA cross-sectional study was conducted to assess preterm feeding practices across Pakistani NICUs. Of the 100 NICUs approached, 48 (48%) participated in the study. Data was collected using a self-administered, validated questionnaire developed to evaluate hospital-based feeding practices, including feeding initiation protocols and adherence to clinical guidelines, fortification practices, barriers and challenges influencing feeding decisions, key determinants of feeding choices, growth monitoring protocols, and provision of lactation. The data were analyzed using chi-square, Fisher's exact test, and the Mann-Whitney U test, with significance at a 95% probability level.SummaryOne neonatologist from each NICU participated; most respondents had 1-5 years of experience (45.8%), and 60.4% were from private hospitals. Both settings showed comparable use of the mother's own milk. However, private hospitals had longer waiting times before initiating alternative feeding (median 1.00 vs. 0.00, p = 0.005) and lower immediate Kangaroo Mother Care initiation (48.3% vs. 84.2%, p = 0.039). Commercial fortifier use was higher in private hospitals (37.9% vs. 10.5%, p = 0.049), while medium-chain triglyceride oil was the most common fortifier overall. Private hospitals more frequently reported unavailability of expressed breast milk (55.2% vs. 26.3%, p = 0.049) and insufficient milk supply (89.6% vs. 47.4%, p = 0.001). Government hospitals more commonly identified untrained staff (52.6% vs. 17.2%, p = 0.01) and parental reluctance (57.9% vs. 27.6%, p = 0.036) as barriers. FAU - Latif, Samreen AU - Latif S AUID- ORCID: 0009-0005-8434-0372 AD - Department of Nutrition and Dietetics, University of Management and Technology, Lahore, Pakistan. RINGGOLD: 66915 FAU - Khalid, Nauman AU - Khalid N AUID- ORCID: 0000-0002-8045-199X AD - Department of Food Science and Technology, University of Management and Technology, Lahore, Pakistan. RINGGOLD: 66915 AD - College of Health Sciences, Abu Dhabi University, Abu Dhabi, United Arab Emirates. LA - eng PT - Journal Article DEP - 20260725 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - NICU OT - Pakistan OT - Preterm infants OT - feeding practices OT - fortification EDAT- 2026/07/25 23:59 MHDA- 2026/07/25 23:59 CRDT- 2026/07/25 08:33 PHST- 2026/07/25 23:59 [medline] PHST- 2026/07/25 23:59 [pubmed] PHST- 2026/07/25 08:33 [entrez] AID - 10.1177/02601060261471951 [doi] PST - aheadofprint SO - Nutr Health. 2026 Jul 25:2601060261471951. doi: 10.1177/02601060261471951. PMID- 42500375 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260725 LR - 20260813 IS - 2231-0762 (Print) IS - 2250-1002 (Electronic) IS - 2231-0762 (Linking) VI - 16 IP - 3 DP - 2026 May-Jun TI - Association between Salivary Cortisol, Secretory IgA, and Inflammatory Cytokines with Early Childhood Caries: A Cross-sectional Analytical Study. PG - 279-284 LID - 10.4103/jispcd.jispcd_201_25 [doi] AB - OBJECTIVE: Early childhood caries (ECC) is a multifactorial disease driven by biological and psychosocial determinants. Identifying noninvasive biomarkers could improve risk stratification and personalized prevention. The aim of the study is to evaluate the association of salivary cortisol, total secretory immunoglobulin A (sIgA), and pro-inflammatory cytokines (interleukin-6 [IL-6], interleukin-1beta [IL-1beta], and tumor necrosis factor-alpha [TNF-alpha]) with ECC in preschool children.IL-1beta. MATHODS: This cross-sectional analytical study included 120 children aged 3-6 years (60 ECC; 60 caries-free). Unstimulated saliva was collected via passive drooling. Biomarkers were quantified using high-sensitivity enzyme-linked immunosorbent assay kits. Multivariable logistic regression and receiver operating characteristic (ROC) curve analysis were performed, adjusting for age, sex, feeding practices, oral hygiene, and socioeconomic status (SES). RESULTS: Children with ECC exhibited significantly higher levels of salivary cortisol (8.92 + -2.11 vs. 5.21 + -1.98 ng/mL, P < 0.001), IL-6 (42.81 + -10.29 vs. 26.44+ -9.87 pg/mL, P < 0.001), and TNF-alpha (P = 0.002) compared to controls. Conversely, sIgA levels were significantly lower in the ECC group (11.34 + -4.12 vs.18.25 + -5.03 mg/dL, P < 0.001). ROC analysis identified cortisol (area under the curve [AUC] = 0.89) and sIgA (AUC = 0.86) as excellent diagnostic indicators. In the final multivariable model, cortisol (OR 3.94, 95% confidence interval [CI] 2.11-7.35) and sIgA (OR 0.44, 95% CI 0.28-0.70) remained independently associated with ECC after adjusting for SES and behavioral covariates. CONCLUSION: Salivary cortisol, sIgA, and inflammatory cytokines are significantly associated with ECC, reflecting complex interactions between stress physiology, mucosal immunity, and oral dysbiosis. While these biomarkers show promise as early-warning indicators, longitudinal data are required to establish their discriminatory utility for caries onset. CI - Copyright: (c) 2026 Journal of International Society of Preventive and Community Dentistry. FAU - Acharya, Sonu AU - Acharya S AD - Department of Pediatric and Preventive Dentistry, Institute of Dental Sciences, Siksha 'O' Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India. FAU - Godhi, Brinda Suhas AU - Godhi BS AD - Department of Pediatric and Preventive Dentistry, JSS Dental College and Hospital, JSS Academy of Higher Education and Research, Mysuru, Karnataka, India. FAU - Nalawade, Triveni Mohan AU - Nalawade TM AD - Department of Paediatric Dentistry, Oman Dental College, Muscat, Oman. FAU - Mallikarjuna, Rachappa AU - Mallikarjuna R AD - Department of Paediatric Dentistry, Oman Dental College, Muscat, Oman. FAU - Shivagange, Vinay AU - Shivagange V AD - Department of Endodontolgy, Oman Dental College, Muscat, Oman. FAU - Alsenaidi, Amur AU - Alsenaidi A AD - Head of Clinical Affairs, Oman Dental College, Muscat, Oman. LA - eng PT - Journal Article DEP - 20260516 PL - India TA - J Int Soc Prev Community Dent JT - Journal of International Society of Preventive & Community Dentistry JID - 101618802 PMC - PMC13397212 OTO - NOTNLM OT - Cortisol OT - cytokines OT - early childhood caries OT - risk assessment OT - salivary biomarkers OT - secretory IgA COIS- There are no conflicts of interest. EDAT- 2026/07/25 06:36 MHDA- 2026/07/25 06:37 PMCR- 2026/05/16 CRDT- 2026/07/25 05:03 PHST- 2025/11/18 00:00 [received] PHST- 2026/02/10 00:00 [revised] PHST- 2026/02/19 00:00 [accepted] PHST- 2026/07/25 06:37 [medline] PHST- 2026/07/25 06:36 [pubmed] PHST- 2026/07/25 05:03 [entrez] PHST- 2026/05/16 00:00 [pmc-release] AID - JISPCD-16-279 [pii] AID - 10.4103/jispcd.jispcd_201_25 [doi] PST - epublish SO - J Int Soc Prev Community Dent. 2026 May 16;16(3):279-284. doi: 10.4103/jispcd.jispcd_201_25. eCollection 2026 May-Jun. PMID- 42500238 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260725 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Psychological barriers in future food gatekeepers: How germ aversion and perceived infectability mediate nutrition-related food neophobia among pre-service preschool teachers. PG - 1863520 LID - 10.3389/fnut.2026.1863520 [doi] LID - 1863520 AB - BACKGROUND: The development of nutritional health literacy in early childhood is structurally influenced by adult food gatekeepers. Approached as a sociological study of food, this research investigates the relationship between Nutrition-Related Food Neophobia (NRFN) and Food Disgust (FD) among pre-service preschool teachers, examining the mediating roles of the Behavioral Immune System-specifically Perceived Infectability (PI) and Germ Aversion (GA)-as underlying behavioral determinants. METHODS: A cross-sectional survey was conducted among 548 pre-service preschool teachers (males 43.2%, females 56.8%) in Changsha, China. Participants completed validated scales including the Perceived Vulnerability to Disease Questionnaire, the Nutrition-Related Food Neophobia Scale, and the Food Disgust Scale, evaluating biofortified rice as a nutritional stimulus. Data were analyzed using a two-step Structural Equation Modeling (SEM) approach. RESULTS: SEM analysis revealed that NRFN was significantly and positively associated with FD. PI and GA collectively mediated this relationship, explaining 54.69% of the total effect. The mediating influence of GA (30.98%) was numerically larger than that of PI (23.71%), indicating that the hygiene training of future educators may inadvertently contribute to their affective, evolutionary resistance to novel nutritional foods over their cognitive immune assessments. CONCLUSION: Despite the formal health and nutritional training anticipated in pre-service educators, our findings suggest that evolutionary pathogen-avoidance mechanisms continue to be strongly associated with their food aversion. These psychological barriers can potentially limit the implementation fidelity of nutritional educational tools within the kindergarten's social space of food. Enhancing children's dietary diversity and health literacy could benefit from shifting preventive strategies upstream, integrating food sociology and evolutionary psychology into teacher-training programs to dismantle germ aversion and build psychological resilience. CI - Copyright (c) 2026 Xing and Wu. FAU - Xing, Lu AU - Xing L AD - School of Preschool Education, Changsha Normal University, Changsha, China. AD - School of Education, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. FAU - Wu, Xueqi AU - Wu X AD - Taylor's Culinary Institute, Faculty of Social Sciences and Leisure Management, Taylor's University, Subang Jaya, Malaysia. LA - eng PT - Journal Article DEP - 20260710 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13397584 OTO - NOTNLM OT - food disgust OT - germ aversion OT - nutrition-related food Neophobia OT - perceived infectability OT - pre-service teachers COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/25 06:36 MHDA- 2026/07/25 06:37 PMCR- 2026/07/10 CRDT- 2026/07/25 05:01 PHST- 2026/04/23 00:00 [received] PHST- 2026/06/19 00:00 [revised] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/07/25 06:37 [medline] PHST- 2026/07/25 06:36 [pubmed] PHST- 2026/07/25 05:01 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - 10.3389/fnut.2026.1863520 [doi] PST - epublish SO - Front Nutr. 2026 Jul 10;13:1863520. doi: 10.3389/fnut.2026.1863520. eCollection 2026. PMID- 42500102 OWN - NLM STAT- Publisher LR - 20260813 IS - 2589-1081 (Electronic) IS - 2095-8811 (Print) IS - 2095-8811 (Linking) DP - 2026 May 12 TI - Drug-Induced Sleep Endoscopy in Children Predicts OSA Severity. LID - 10.1002/wjo2.70098 [doi] AB - BACKGROUND: While adenotonsillectomy (AT) is first line for pediatric obstructive sleep apnea (OSA), treatment failure is common. Drug-induced sleep endoscopy (DISE) provides dynamic airway assessment, but its role in predicting OSA severity requires clarification. This study correlates DISE findings with polysomnographic severity. OBJECTIVE: To determine the association between DISE-based obstruction patterns and OSA severity in children. METHODS: This prospective study included 95 children with adenotonsillar hypertrophy. All underwent preoperative Level III polysomnography followed by DISE before AT. Two blinded otolaryngologists independently reviewed DISE recordings, classifying obstruction via the VOTE system (degree 0-2; pattern: concentric, lateral, or anteroposterior). Statistical analysis employed non-parametric tests, relative risk calculation, and ROC curves. RESULTS: Severe OSA (AHI > 10) was significantly associated with Brodsky grade IV tonsils (40.7% vs. 16.7%) and severe adenoid hypertrophy (44.1% vs. 16.7%). DISE identified severe obstruction at the velopharynx (p = 0.003) and tongue base (p = 0.036) as specific predictors of severe OSA, with high specificities (91% and 97.1%) and positive predictive values (87.7% and 90.9%). Concentric collapse was the most frequent velopharyngeal pattern (54.2%). Obesity was significantly linked to severe tongue base obstruction (38.9% vs. 5.4%, p = 0.001) and higher AHI. ROC analysis for tongue base obstruction combined with the Obstructive Apnea Index (OAI) showed high diagnostic accuracy (AUC = 0.811). DISCUSSION AND CONCLUSION: DISE is a valuable tool for predicting pediatric OSA severity. Obstruction at the velopharynx and tongue base, particularly concentric collapse and in the context of obesity, are key risk factors. Integrating DISE findings with PSG enhances preoperative risk stratification, aiding in the selection of candidates who may benefit from personalized, multilevel surgical interventions. CI - (c) 2026 The Author(s). World Journal of Otorhinolaryngology - Head and Neck Surgery published by John Wiley & Sons Ltd on behalf of Chinese Medical Association. FAU - Carneiro, Neemias Santos AU - Carneiro NS AUID- ORCID: 0000-0002-7917-4374 AD - Sao Paulo State University, Botucatu Medical School (FMB-UNESP) Botucatu Sao Paulo Brazil. FAU - Marao, Antonio Carlos AU - Marao AC AUID- ORCID: 0000-0002-7948-329X AD - Clinical Hospital of the Faculty of Medicine of Botucatu (HCFMB) - UNESP Botucatu Sao Paulo Brazil. FAU - Santana, Renato Battistel AU - Santana RB AUID- ORCID: 0000-0002-3888-541X AD - Sao Paulo State University, Botucatu Medical School (FMB-UNESP) Botucatu Sao Paulo Brazil. FAU - Correa, Camila de Castro AU - Correa CC AUID- ORCID: 0000-0001-5460-3120 AD - University Vale do Rio Doce, UNIVALE, Governador Valadares Governador Valadares MG Brazil. FAU - Weber, Silke Anna Theresa AU - Weber SAT AUID- ORCID: 0000-0003-3194-3039 AD - Sao Paulo State University, Botucatu Medical School (FMB-UNESP) Botucatu Sao Paulo Brazil. LA - eng PT - Journal Article DEP - 20260512 PL - United States TA - World J Otorhinolaryngol Head Neck Surg JT - World journal of otorhinolaryngology - head and neck surgery JID - 101690857 PMC - PMC13399433 OTO - NOTNLM OT - OSA OT - Z-score OT - adenoidectomy OT - sonoendoscopy OT - tonsillectomy COIS- The authors declare that there are no conflicts of interest related to this study. They have no financial, institutional, or personal relationships that could have influenced the work reported in this manuscript. No affiliations with any organization or publisher have biased the research. EDAT- 2026/07/25 06:36 MHDA- 2026/07/25 06:36 PMCR- 2026/05/12 CRDT- 2026/07/25 05:00 PHST- 2025/07/06 00:00 [received] PHST- 2025/12/01 00:00 [revised] PHST- 2026/02/01 00:00 [accepted] PHST- 2026/07/25 06:36 [medline] PHST- 2026/07/25 06:36 [pubmed] PHST- 2026/07/25 05:00 [entrez] PHST- 2026/05/12 00:00 [pmc-release] AID - WJO270098 [pii] AID - 10.1002/wjo2.70098 [doi] PST - aheadofprint SO - World J Otorhinolaryngol Head Neck Surg. 2026 May 12:10.1002/wjo2.70098. doi: 10.1002/wjo2.70098. PMID- 42499772 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260829 LR - 20260829 IS - 2574-2272 (Electronic) IS - 2096-3726 (Print) IS - 2574-2272 (Linking) VI - 10 IP - 4 DP - 2026 Aug TI - Evidence map and gap analysis of metabolic change in pediatric growth hormone deficiency treated with growth hormone. PG - 359-373 LID - 10.1002/ped4.70050 [doi] AB - IMPORTANCE: Recombinant human growth hormone (rhGH) improves height in children with growth hormone deficiency (GHD). However, its metabolic effects remain unclear. OBJECTIVE: To synthesize evidence regarding the metabolic effects of rhGH or growth hormone (GH) derivatives in GHD, identify knowledge gaps, and highlight future research priorities. METHODS: PubMed, Embase, the Cochrane Library, China National Knowledge Infrastructure, China Biology Medicine disc, and Wanfang databases were searched in July 2023 to identify studies on metabolic effects of GH treatment. Bubble plots were used to visualize GH treatment effects on metabolic parameters according to treatment duration by comparison with baselines, nonpharmacological interventions, and healthy controls. Random-effects meta-analyses were conducted for outcomes with inconsistent findings across original studies when randomized controlled trial data were sufficient. The study was registered with INPLASY (INPLASY202450064). RESULTS: Sixty-three studies (6158 participants) analyzed the effects of GH treatment on metabolic outcomes in children with GHD. Overall, GH treatment slightly affected glucose levels; lipid effects were inconsistent. GH treatment did not influence bone mineral density, bone mineral content, or parathyroid hormone levels. Most studies showed no significant effects on thyroid hormone levels, body composition, or body mass index (BMI). GH treatment may increase serum asymmetric dimethylarginine and gastrin levels while reducing tumor necrosis factor and serum urea levels. INTERPRETATION: Glucose and thyroid outcomes are consistent with clinical observations; effects on lipids, calcium, phosphorus, body composition, BMI, and waist-to-hip ratio require further validation owing to data inconsistency. New biomarkers are warranted. Further clinical studies are needed in children across age groups, GHD severities, and nutritional statuses. CI - (c) 2026 The Author(s). Pediatric Investigation published by John Wiley & Sons Australia, Ltd on behalf of Futang Research Center of Pediatric Development. FAU - Wu, Wei AU - Wu W AD - Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. 1095, Jiefang Wuhan Hubei 430030 China. FAU - Song, Ningyi AU - Song N AD - Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. 1095, Jiefang Wuhan Hubei 430030 China. FAU - Zhao, Yue AU - Zhao Y AD - Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. 1095, Jiefang Wuhan Hubei 430030 China. FAU - Du, Caiqi AU - Du C AD - Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. 1095, Jiefang Wuhan Hubei 430030 China. FAU - Zhao, Yuning AU - Zhao Y AUID- ORCID: 0009-0007-2154-9624 AD - Medical Affairs Novo Nordisk (Shanghai) Pharma Trading Co., Ltd. No.8, Guangshunnan Beijing 100102 China. FAU - Wu, You AU - Wu Y AD - Medical Affairs Novo Nordisk (Shanghai) Pharma Trading Co., Ltd. No.8, Guangshunnan Beijing 100102 China. FAU - Luo, Xiaoping AU - Luo X AD - Department of Pediatrics Tongji Hospital Tongji Medical College Huazhong University of Science and Technology No. 1095, Jiefang Wuhan Hubei 430030 China. LA - eng PT - Journal Article PT - Review DEP - 20260311 PL - United States TA - Pediatr Investig JT - Pediatric investigation JID - 101731527 PMC - PMC13398671 OTO - NOTNLM OT - Evidence map OT - Growth hormone deficiency OT - Metabolism OT - Systematic review COIS- Wei Wu, Ningyi Song, Yue Zhao, and Caiqi Du declare no conflict of interest. Yuning Zhao and You Wu are employees and stockholders of Novo Nordisk, but are not involved in data processing. Xiaoping Luo serves as an advisor to GenSci, Amoytop, Novo Nordisk, Takeda, Lumos, Sanofi, Medtronic, Ipsen, Visen, and Kyowa Kirin, providing research support for GenSci, Amoytop, Novo Nordisk, Takeda, Lumos, Sanofi, Medtronic, Ipsen, Visen, and Kyowa Kirin, and is a speaker for GenSci, Novo Nordisk, and Visen. Xiaoping Luo is a member of the Pediatric Investigation Editorial Board. The study design, analytical plan, and interpretation remained under the full control of the academic authors, and the outcome selection was driven by clinical relevance and protocol pre-specification. EDAT- 2026/07/25 06:36 MHDA- 2026/07/25 06:37 PMCR- 2026/03/11 CRDT- 2026/07/25 04:58 PHST- 2025/07/08 00:00 [received] PHST- 2026/02/05 00:00 [accepted] PHST- 2026/07/25 06:37 [medline] PHST- 2026/07/25 06:36 [pubmed] PHST- 2026/07/25 04:58 [entrez] PHST- 2026/03/11 00:00 [pmc-release] AID - PED470050 [pii] AID - 10.1002/ped4.70050 [doi] PST - epublish SO - Pediatr Investig. 2026 Mar 11;10(4):359-373. doi: 10.1002/ped4.70050. eCollection 2026 Aug. PMID- 42499750 OWN - NLM STAT- Publisher LR - 20260813 IS - 2691-171X (Electronic) IS - 2691-171X (Linking) DP - 2026 Jul 2 TI - A joint transdisciplinary approach for paediatric inflammatory bowel disease: Integrating nursing, dietetic and psychological support. LID - 10.1002/jpr3.70216 [doi] AB - Paediatric inflammatory bowel disease (pIBD) is a long-term, immune-mediated condition characterised by fluctuating gastrointestinal symptoms, nutritional risk and psychosocial difficulties. Although multidisciplinary team (MDT) support is considered the gold standard, there is considerable variation in how it is delivered, and it remains common for healthcare services to rely on separate discipline-specific appointments within the MDT. Here, we describe a transdisciplinary model for pIBD that integrates nursing, dietetic and psychological expertise within a joint appointment. Through the methodology of reflective practice, we identify several potential benefits, including more holistic symptom management, enhanced access to specialist input, reduced stigma around psychological support and improved cross-disciplinary learning. Potential implementation challenges include implementation feasibility, role ambiguity and demands on some service users. To the best of our knowledge, this paper represents an innovative model of care for pIBD. CI - (c) 2026 The Author(s). JPGN Reports published by Wiley Periodicals LLC on behalf of The European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Yau, King-Chi AU - Yau KC AUID- ORCID: 0000-0003-1778-9688 AD - Research Department of Clinical, Educational and Health Psychology University College London London UK. AD - Paediatric Gastroenterology, St Mark's Hospital London North West University Healthcare NHS Trust London UK. FAU - Tesser, Laura AU - Tesser L AD - Paediatric Gastroenterology, St Mark's Hospital London North West University Healthcare NHS Trust London UK. FAU - Crook, Kay AU - Crook K AD - Paediatric Gastroenterology, St Mark's Hospital London North West University Healthcare NHS Trust London UK. LA - eng PT - Journal Article DEP - 20260702 PL - United States TA - JPGN Rep JT - JPGN reports JID - 101773885 PMC - PMC13399047 OTO - NOTNLM OT - child OT - gastroenterology OT - multidisciplinary COIS- The authors declare no conflicts of interest. EDAT- 2026/07/25 06:36 MHDA- 2026/07/25 06:36 PMCR- 2026/07/02 CRDT- 2026/07/25 04:58 PHST- 2025/12/24 00:00 [received] PHST- 2026/03/04 00:00 [revised] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/07/25 06:36 [medline] PHST- 2026/07/25 06:36 [pubmed] PHST- 2026/07/25 04:58 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - JPR370216 [pii] AID - 10.1002/jpr3.70216 [doi] PST - aheadofprint SO - JPGN Rep. 2026 Jul 2:10.1002/jpr3.70216. doi: 10.1002/jpr3.70216. PMID- 42499215 OWN - NLM STAT- Publisher LR - 20260725 IS - 1544-0591 (Electronic) IS - 0022-0345 (Linking) DP - 2026 Jul 24 TI - Salivary Dipeptides and Microbiota Multiomics Biomarkers of Caries. PG - 220345261466143 LID - 10.1177/00220345261466143 [doi] AB - Dental caries is a prevalent disease shaped by dietary and metabolic interactions between the host and oral microbiota. While separate microbiome and metabolome profiling have improved the understanding of caries etiology, integrated multiomics approaches remain underutilized. We aimed to identify salivary biomarkers of caries experience in a cross-sectional study combining microbiome, metabolome, sugarome, and diet, oral, and demographic information in 217 healthy Swedish adolescents and young adults. Participants underwent clinical examination, dietary assessment, and saliva analysis using full-length 16S rRNA gene sequencing, untargeted liquid chromatography-mass spectrometry (LC-MS) metabolomics, and 2-dimensional gas chromatography-MS (GCxGC-MS)-based sugar profiling. Caries signs and restorations were summarized as decayed and filled surfaces including enamel caries. Associations between caries experience, demographics, and omics measures were evaluated using a nested cross-validated linear-regression framework with inner-loop feature selection and outer-loop performance assessment, emphasizing effect-direction stability and reproducibility across cross-validation models. Selected OMICs features were then integrated using orthogonal partial least-squares (OPLS) modeling. Three salivary dipeptides (Ser-Pro, Phe-His, and Thr-Gly) showed robust inverse associations with caries experience. Several cariogenic taxa, including Streptococcus mutans, Streptococcus sobrinus, Lactobacillus gasseri, and selected Actinomyces and Prevotella species, were positively associated with caries experience, whereas Veillonella rogosae, Stomatobaculum sp. HMT-097, and other taxa as well as 5 bacteria-predicted enzymes were associated with lower caries experience. Dietary variables and salivary sugars showed no consistent associations with caries experience. An integrated OPLS model incorporating demographics, microbiota composition, microbial-predicted enzymes, and metabolomics explained 41% of the variation in caries (R(2) = 0.41) with a cross-validated predictive ability of 30% (Q(2) = 0.30). This saliva-based multiomics framework revealed coherent microbial and metabolic signatures of caries experience. The Ser-Pro dipeptide showed the strongest inverse association and warrants validation in longitudinal cohorts to establish temporal precedence and clinical utility as a novel caries biomarker. FAU - Haworth, S AU - Haworth S AUID- ORCID: 0000-0001-7793-7326 AD - Department of Odontology, University of Umea, Umea, Sweden. AD - Bristol Dental School, University of Bristol, Bristol, UK. FAU - Esberg, A AU - Esberg A AUID- ORCID: 0000-0002-4430-8125 AD - Department of Odontology, University of Umea, Umea, Sweden. FAU - Eriksson, L AU - Eriksson L AD - Department of Odontology, University of Umea, Umea, Sweden. FAU - Ahmed, H AU - Ahmed H AD - Department of Life Technologies, Food Sciences Unit, University of Turku, Turku, Finland. FAU - Mack, C I AU - Mack CI AD - Max Rubner-Institute, Department of Safety and Quality of Fruit and Vegetables, Karlsruhe, Germany. FAU - Noerman, S AU - Noerman S AD - Clinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), Singapore. AD - Department of Life Sciences, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden. FAU - Nordin, E AU - Nordin E AD - Department of Life Sciences, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden. FAU - Egert, B AU - Egert B AD - Max Rubner-Institute, Department of Safety and Quality of Fruit and Vegetables, Karlsruhe, Germany. FAU - Hanhineva, K AU - Hanhineva K AD - Department of Life Technologies, Food Sciences Unit, University of Turku, Turku, Finland. FAU - Landberg, R AU - Landberg R AD - Department of Life Sciences, Division of Food and Nutrition Science, Chalmers University of Technology, Gothenburg, Sweden. FAU - Brunius, C AU - Brunius C AD - Clinical Nutrition Research Centre (CNRC), Singapore Institute of Food and Biotechnology Innovation (SIFBI), Agency for Science, Technology and Research (A*STAR), Singapore. FAU - Johansson, I AU - Johansson I AD - Department of Odontology, University of Umea, Umea, Sweden. LA - eng PT - Journal Article DEP - 20260724 PL - United States TA - J Dent Res JT - Journal of dental research JID - 0354343 SB - IM OTO - NOTNLM OT - dental caries OT - metabolomics OT - microbiome OT - omics OT - saliva OT - sugars EDAT- 2026/07/25 06:36 MHDA- 2026/07/25 06:36 CRDT- 2026/07/25 01:53 PHST- 2026/07/25 06:36 [medline] PHST- 2026/07/25 06:36 [pubmed] PHST- 2026/07/25 01:53 [entrez] AID - 10.1177/00220345261466143 [doi] PST - aheadofprint SO - J Dent Res. 2026 Jul 24:220345261466143. doi: 10.1177/00220345261466143. PMID- 42499051 OWN - NLM STAT- MEDLINE DCOM- 20260725 LR - 20260821 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 30 DP - 2026 Jul 24 TI - Research status, hotspots, and frontiers in functional abdominal pain syndrome: A bibliometric and visual analysis. PG - e49899 LID - 10.1097/MD.0000000000049899 [doi] LID - e49899 AB - BACKGROUND: Functional abdominal pain syndrome (FAPS) is a relatively uncommon functional gastrointestinal disorder. Recent years have witnessed substantial advancements in the study of FAPS; however, no bibliometric analyses have been conducted to date. OBJECTIVE: This study systematically reviews current research and emerging issues in the field of FAPS using bibliometric methods to understand research trends and future development prospects. METHODS: The foundational literature in the field of FAPS was sourced from the Web of Science database. Visual analysis was performed using CiteSpace and VOSviewer software, focusing on factors such as the number of published papers, countries (regions), research institutions, journals, authors, highly cited papers, and keywords. RESULTS: From 1996 to 2025, 996 publications were analyzed, showing a phased growth in annual publication volume peaking in 2021. The United States led in publications and centrality. The "Journal of Pediatric Gastroenterology and Nutrition" had the highest publication count. Marc A. Benninga authored the most articles, notably "Functional Disorders: Children and Adolescents." The prevalent keyword was "children." Research on FAPS focuses on evolving disease definitions, the "brain-gut interaction disorder" paradigm, the microbiota-gut-brain axis, children with irritable bowel syndrome, functional abdominal pain, and nonpharmaceutical therapies like probiotics, dietary interventions, and cognitive behavioral therapy. Pediatric populations and non-pharmacological interventions were the most prominent themes, whereas adult-specific research and biomarker-related studies appeared less frequently. CONCLUSION: This bibliometric study identified key research areas including the microbiota-gut-brain axis, pediatric populations, and non-pharmacological interventions, alongside emerging topics such as gut-brain interaction disorders. These findings suggest that future research should prioritize large-scale trials validating non-pharmacological therapies and biomarkers for central sensitization. Clinically, the development of age-specific diagnostic protocols and interdisciplinary management teams integrating gastroenterology, neurology, and psychology is warranted to improve patient outcomes. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Zhou, Ziqin AU - Zhou Z AUID- ORCID: 0009-0009-0176-9771 AD - Department of Acupuncture and Moxibustion, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China. FAU - Liu, Liu AU - Liu L AUID- ORCID: 0009-0001-2866-3303 AD - Department of Acupuncture and Moxibustion, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China. FAU - Fu, Jia AU - Fu J AD - The Fourth School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Yan, Huixin AU - Yan H AD - Affiliated Hospital of Nanjing University with Chinese Medicine, Nanjing, China. FAU - Sheng, Yan AU - Sheng Y AD - Affiliated Hospital of Nanjing University with Chinese Medicine, Nanjing, China. FAU - Zhang, Zhaohui AU - Zhang Z AUID- ORCID: 0000-0002-6154-3901 AD - Department of Acupuncture and Moxibustion, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China. LA - eng PT - Journal Article PT - Review PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - *Bibliometrics MH - *Abdominal Pain/therapy MH - *Gastrointestinal Diseases PMC - PMC13406295 OTO - NOTNLM OT - Functional abdominal pain syndrome OT - Web of Science OT - bibliometric analysis OT - gut-brain axis OT - research trends COIS- The authors have no conflicts of interest to declare. EDAT- 2026/07/25 06:36 MHDA- 2026/07/25 06:37 PMCR- 2026/07/24 CRDT- 2026/07/25 01:03 PHST- 2026/03/12 00:00 [received] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/25 06:37 [medline] PHST- 2026/07/25 06:36 [pubmed] PHST- 2026/07/25 01:03 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - 00005792-202607240-00030 [pii] AID - MD-D-26-03905 [pii] AID - 10.1097/MD.0000000000049899 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jul 24;105(30):e49899. doi: 10.1097/MD.0000000000049899. PMID- 42497592 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260831 IS - 1872-8464 (Electronic) IS - 0165-5876 (Linking) VI - 208 DP - 2026 Sep TI - Vestibular Infant Screening - Rehabilitation: A pilot study assessing preliminary effectiveness and feasibility of vestibular rehabilitation therapy in children with peripheral vestibular dysfunction. PG - 112957 LID - S0165-5876(26)00253-3 [pii] LID - 10.1016/j.ijporl.2026.112957 [doi] AB - OBJECTIVES: This pilot study aims to evaluate the preliminary effects and feasibility of the Vestibular Infant Screening - Rehabilitation (VIS-REHAB) protocol, a structured Vestibular Rehabilitation Therapy (VRT) program combining postural and gaze stability exercises, in children with peripheral vestibular dysfunction. METHODS: Four children (aged 4-14 years) with peripheral vestibular dysfunction were recruited from the Ghent University Hospital and enrolled in a two-parallel-group randomized controlled crossover trial comparing the VIS-REHAB protocol with a no-therapy control. The VIS-REHAB protocol consisted of structured exercises targeting postural (20 min) and gaze stability (10 min), delivered in 30-min sessions twice weekly over nine weeks. Primary and secondary outcome measures included postural stability, gaze stability, motor performance, and quality of life. Descriptive analyses were conducted for each participant. RESULTS: All participants demonstrated improvements in the postural (Bruininks-Oseretsky Test of Motor Proficiency (BOT-2) Balance Subtest) and gaze stability (Gaze Stabilization Test) during therapy, while changes during the no-therapy period were more variable and generally less pronounced. Among the secondary outcomes, improvements were observed in the Pediatric Modified Dynamic Gait Index, BOT-2 Bilateral Coordination Subtest, and Dynamic Visual Acuity Test. Children and caregivers reported better balance, a perceived reduction in falls, and increased participation in daily life. The protocol was feasible and well-tolerated, though some age-related limitations were noted. CONCLUSIONS: The protocol is feasible and may improve postural and gaze stability in children with peripheral vestibular dysfunction. A larger trial is planned to confirm these findings. This research presents an important first step towards developing evidence-based guidelines for pediatric VRT. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Fontaine, Marieke AU - Fontaine M AD - Faculty of Medicine and Health Sciences, Department of Rehabilitation Sciences, Ghent University, Corneel Heymanslaan 10, Gent, 9000, Belgium; Faculty of Medicine and Health Sciences, Department of Head and Skin, Ghent University, Corneel Heymanslaan 10, Gent, 9000, Belgium. Electronic address: Marieke.Fontaine@UGent.be. FAU - De Leenheer, Els AU - De Leenheer E AD - Faculty of Medicine and Health Sciences, Department of Head and Skin, Ghent University, Corneel Heymanslaan 10, Gent, 9000, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Ghent, Corneel Heymanslaan 10, Gent, 9000, Belgium. Electronic address: Els.DeLeenheer@UGent.be. FAU - Van den Bossche, Lena AU - Van den Bossche L AD - Faculty of Medicine and Health Sciences, Department of Head and Skin, Ghent University, Corneel Heymanslaan 10, Gent, 9000, Belgium. Electronic address: Lena.VandenBossche@UGent.be. FAU - Van Hecke, Ruth AU - Van Hecke R AD - Faculty of Medicine and Health Sciences, Department of Rehabilitation Sciences, Ghent University, Corneel Heymanslaan 10, Gent, 9000, Belgium. Electronic address: Ruth.VanHecke@UGent.be. FAU - Dhooge, Ingeborg AU - Dhooge I AD - Faculty of Medicine and Health Sciences, Department of Head and Skin, Ghent University, Corneel Heymanslaan 10, Gent, 9000, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Ghent, Corneel Heymanslaan 10, Gent, 9000, Belgium. Electronic address: Ingeborg.Dhooge@UGent.be. FAU - Braswell Christy, Jennifer AU - Braswell Christy J AD - School of Health Professions, Department of Physical Therapy, University of Alabama at Birmingham, 1716 9th Avenue South, Birmingham, AL, 35233, United States. Electronic address: jbraswel@uab.edu. FAU - Maes, Leen AU - Maes L AD - Faculty of Medicine and Health Sciences, Department of Rehabilitation Sciences, Ghent University, Corneel Heymanslaan 10, Gent, 9000, Belgium; Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Ghent, Corneel Heymanslaan 10, Gent, 9000, Belgium. Electronic address: Leen.Maes@UGent.be. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260721 PL - Ireland TA - Int J Pediatr Otorhinolaryngol JT - International journal of pediatric otorhinolaryngology JID - 8003603 SB - IM MH - Humans MH - Pilot Projects MH - Child MH - Child, Preschool MH - Male MH - Female MH - *Vestibular Diseases/rehabilitation/diagnosis/physiopathology MH - Feasibility Studies MH - Postural Balance/physiology MH - Adolescent MH - Cross-Over Studies MH - Treatment Outcome MH - *Exercise Therapy/methods MH - Quality of Life MH - Vestibular Function Tests OTO - NOTNLM OT - Gaze stability OT - Pediatric vestibular rehabilitation OT - Pediatric vestibular rehabilitation therapy OT - Postural control OT - Vestibular dysfunction OT - Vestibular rehabilitation OT - Vestibular rehabilitation therapy COIS- Declaration of competing interest The authors declare that they have no known competing financial interest or personal relationship that could have appeared to influence the work reported in this paper. EDAT- 2026/07/25 00:35 MHDA- 2026/08/18 23:36 CRDT- 2026/07/24 18:07 PHST- 2025/12/09 00:00 [received] PHST- 2026/06/26 00:00 [revised] PHST- 2026/07/19 00:00 [accepted] PHST- 2026/08/18 23:36 [medline] PHST- 2026/07/25 00:35 [pubmed] PHST- 2026/07/24 18:07 [entrez] AID - S0165-5876(26)00253-3 [pii] AID - 10.1016/j.ijporl.2026.112957 [doi] PST - ppublish SO - Int J Pediatr Otorhinolaryngol. 2026 Sep;208:112957. doi: 10.1016/j.ijporl.2026.112957. Epub 2026 Jul 21. PMID- 42497365 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260724 LR - 20260813 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 9 DP - 2026 Jul 24 TI - AI and Chatbot-Supported Interventions for Physical Activity and Obesity-Related Lifestyle Behaviors: Scoping Review With Attention to Family Involvement. PG - e98889 LID - 10.2196/98889 [doi] LID - e98889 AB - BACKGROUND: AI-enabled chatbots and related conversational systems can facilitate human-computer interaction through natural language, personalization, and automated support. In pediatric health promotion, these tools have the potential to provide scalable and flexible approaches to support physical activity (PA) and related lifestyle behavior change within family contexts. However, evidence regarding AI and chatbot-supported interventions for PA and obesity-related lifestyle behaviors among children and adolescents remains limited, and the extent to which these interventions involve parents, caregivers, or families has not been clearly characterized. OBJECTIVE: This scoping review aimed to provide an up-to-date overview of how AI and chatbot-supported interventions are designed, delivered, and evaluated for PA and obesity-related lifestyle behaviors among children and adolescents, with attention to technology characteristics, family involvement, delivery platforms, outcomes, and research gaps. METHODS: In accordance with PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) guideline, 7 databases (PubMed, Web of Science, APA PsycINFO, Academic Search Complete, CINAHL Ultimate, IEEE Xplore, and Scopus) were searched through February 2026. Two reviewers independently conducted title and abstract screening, followed by full-text screening in Rayyan (Qatar Computing Research Institute). Eligible studies involved children, adolescents, or families; evaluated an AI-enabled chatbot, conversational agent, or related digital system; and addressed PA, exercise, sedentary behavior, screen time, obesity, overweight, or weight management. Diet, sleep, and other lifestyle outcomes were extracted when reported within otherwise eligible studies. Data were extracted and synthesized narratively in accordance with research objectives. RESULTS: Of 2730 records identified, 14 studies met inclusion criteria. Most were published in 2023 or later (n=12, 85.7%) and spanned 10 countries. Mobile app delivery was most common (n=9, 64.3%). AI approaches included rule-based chatbots, hybrid personalization systems, generative AI, and single studies using recommender systems or computer vision. A total of 10 studies (71.4%) included a specific parent, caregiver, or family component. Common intervention features were personalized feedback (n=10, 71.4%), self-monitoring (n=9, 64.3%), and education (n=9, 64.3%). PA was the most common target behavior, often within broader obesity or healthy lifestyle interventions. Among 8 studies reporting direct PA or fitness outcomes, 4 showed significant improvement, 2 found no significant change, and 2 reported mixed or indirect findings. Feasibility, acceptability, usability, and engagement findings were generally favorable across studies, but cultural tailoring was reported in only one study. CONCLUSIONS: AI and chatbot-supported interventions for pediatric PA and obesity-related lifestyle behaviors represent a rapidly emerging but still early-stage field. Family involvement varies considerably across interventions and should be more clearly conceptualized and evaluated in future studies. CI - (c) Qianxia Jiang, Xiayu Summer Chen, Dev Patel, Keith Brazendale, Sualba Alejandro. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org). FAU - Jiang, Qianxia AU - Jiang Q AUID- ORCID: 0000-0003-2230-6097 AD - Department of Health Sciences, University of Central Florida, 4364 Scorpius St, Orlando, FL, 32816, United States, 1 8609318880. FAU - Chen, Xiayu Summer AU - Chen XS AUID- ORCID: 0000-0003-3747-3947 AD - Department of Health Sciences, University of Central Florida, 4364 Scorpius St, Orlando, FL, 32816, United States, 1 8609318880. AD - School of Social Work, University of Central Florida, Florida, United States. FAU - Patel, Dev AU - Patel D AUID- ORCID: 0009-0009-9264-0294 AD - Department of Health Sciences, University of Central Florida, 4364 Scorpius St, Orlando, FL, 32816, United States, 1 8609318880. AD - College of Medicine, University of Central Florida, Florida, United States. FAU - Brazendale, Keith AU - Brazendale K AUID- ORCID: 0000-0001-9233-1621 AD - Department of Health Sciences, University of Central Florida, 4364 Scorpius St, Orlando, FL, 32816, United States, 1 8609318880. FAU - Alejandro, Sualba AU - Alejandro S AUID- ORCID: 0009-0001-4004-1494 AD - Department of Health Sciences, University of Central Florida, 4364 Scorpius St, Orlando, FL, 32816, United States, 1 8609318880. LA - eng PT - Journal Article PT - Review DEP - 20260724 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC13399406 OTO - NOTNLM OT - artificial intelligence OT - chatbot OT - family-based intervention OT - lifestyle behaviors OT - pediatric obesity OT - physical activity COIS- Conflicts of Interest: None declared. EDAT- 2026/07/24 18:36 MHDA- 2026/07/24 18:37 PMCR- 2026/07/24 CRDT- 2026/07/24 15:52 PHST- 2026/04/20 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/07/24 18:37 [medline] PHST- 2026/07/24 18:36 [pubmed] PHST- 2026/07/24 15:52 [entrez] PHST- 2026/07/24 00:00 [pmc-release] AID - v9i1e98889 [pii] AID - 98889 [pii] AID - 10.2196/98889 [doi] PST - epublish SO - JMIR Pediatr Parent. 2026 Jul 24;9:e98889. doi: 10.2196/98889. PMID- 42496475 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260724 LR - 20260826 IS - 2036-749X (Print) IS - 2036-7503 (Electronic) IS - 2036-749X (Linking) VI - 18 IP - 4 DP - 2026 Jul 13 TI - Multicomponent Nutritional Support for Children with Autism Spectrum Disorder: An Exploratory Pilot Study in Vietnam. LID - 10.3390/pediatric18040097 [doi] LID - 97 AB - BACKGROUND: Children with Autism Spectrum Disorder (ASD) frequently exhibit severe food selectivity and micronutrient deficiencies, impacting growth and nutritional status. Evidence on integrated nutritional interventions in resource-constrained settings remains limited. OBJECTIVE: To assess the feasibility and preliminary pre-post changes associated with a 12-week multicomponent nutritional intervention among Vietnamese children with ASD. METHODS: In this exploratory single-arm pilot study, 56 children with ASD (mean age 59.0 +/- 22.3 months; 80.4% male) were recruited from five community centers in Nghe An Province, Vietnam. The intervention comprised caregiver nutrition education, individualized dietary counseling, and daily multi-micronutrient supplementation. Anthropometric indicators, biochemical markers, feeding behaviors, and dietary intake were assessed at baseline and after 12 weeks. Pre-post changes were evaluated using paired statistical tests, and multivariable linear regression examined factors associated with growth response. RESULTS: The study achieved a 100% completion rate, with all 56 recruited participants finishing the 12-week intervention and all scheduled follow-up assessments. Among children < 60 months, mean Weight-for-Age Z-score (WAZ) increased from -0.66 to -0.28 and mean Height-for-Age Z-score (HAZ) from -1.18 to -0.97 (p < 0.001). For children older than 60 months, mean HAZ increased from -0.87 to -0.58 (p < 0.001) and Body Mass Index-for-Age Z-score (BAZ) from -0.20 to 0.06 (p = 0.006). Significant increases occurred in serum zinc (10.29 to 11.72 micromol/L; p = 0.001), ferritin (31.74 to 34.79 ng/mL; p = 0.001), and hemoglobin (122.73 to 124.77 g/L; p = 0.002), while albumin remained unchanged. Concurrent improvements were observed in feeding behaviors and nutrient-dense food intake. Regression analysis indicated that lower baseline anthropometric status was significantly associated with greater gains in WAZ and HAZ. CONCLUSIONS: This community-based multicomponent intervention was feasible and associated with short-term improvements in feeding behaviors, dietary intake, selected biomarkers, and growth measures in children with ASD, supporting further evaluation in randomized controlled trials. FAU - Phan, Ngoc Dieu Thi AU - Phan NDT AUID- ORCID: 0000-0001-7625-4523 AD - School of Preventive Medicine and Public Health, Hanoi Medical University, 1 Ton That Tung Street, Khuong Thuong Ward, Dong Da District, Hanoi 100000, Vietnam. AD - Faculty of Public Health, Vinh Medical University, 161 Nguyen Phong Sac Street, Hung Dung Ward, Vinh City 430000, Vietnam. FAU - Do, Toan Thi Thanh AU - Do TTT AUID- ORCID: 0000-0002-7049-7361 AD - School of Preventive Medicine and Public Health, Hanoi Medical University, 1 Ton That Tung Street, Khuong Thuong Ward, Dong Da District, Hanoi 100000, Vietnam. FAU - Nguyen, Tuan Van AU - Nguyen TV AD - Faculty of Medicine, Vinh Medical University, 161 Nguyen Phong Sac Street, Hung Dung Ward, Vinh City 430000, Vietnam. FAU - Trinh, Ngoc Bao AU - Trinh NB AD - Institute of Nutrition Research and Development, 48B Tang Bat Ho Street, Hai Ba Trung Ward, Hanoi 100000, Vietnam. FAU - Ngo, Huy Gia AU - Ngo HG AUID- ORCID: 0009-0006-5699-7390 AD - School of Preventive Medicine and Public Health, Hanoi Medical University, 1 Ton That Tung Street, Khuong Thuong Ward, Dong Da District, Hanoi 100000, Vietnam. FAU - Ho, Hoa Thi AU - Ho HT AUID- ORCID: 0009-0003-2934-2688 AD - Institute of Nutrition Research and Development, 48B Tang Bat Ho Street, Hai Ba Trung Ward, Hanoi 100000, Vietnam. FAU - Le, Tam Thi Thanh AU - Le TTT AD - Faculty of Medicine, Vinh Medical University, 161 Nguyen Phong Sac Street, Hung Dung Ward, Vinh City 430000, Vietnam. FAU - Ngo, Hiep Tri AU - Ngo HT AUID- ORCID: 0009-0003-9236-5735 AD - Faculty of Public Health, Vinh Medical University, 161 Nguyen Phong Sac Street, Hung Dung Ward, Vinh City 430000, Vietnam. LA - eng GR - Not applicable/Institute of Nutrition Research and Development/ PT - Journal Article DEP - 20260713 PL - Switzerland TA - Pediatr Rep JT - Pediatric reports JID - 101551542 PMC - PMC13398004 OTO - NOTNLM OT - Autism Spectrum Disorder OT - dietary intake OT - growth OT - micronutrients OT - nutrition counseling OT - nutritional intervention COIS- The authors declare no conflicts of interest. The sponsor (INRD) had no role in the design of the study, the collection, analysis, or interpretation of data, the writing of the manuscript, or the decision to publish the results. EDAT- 2026/07/24 12:37 MHDA- 2026/07/24 12:38 PMCR- 2026/07/13 CRDT- 2026/07/24 10:04 PHST- 2026/06/13 00:00 [received] PHST- 2026/07/02 00:00 [revised] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/24 12:38 [medline] PHST- 2026/07/24 12:37 [pubmed] PHST- 2026/07/24 10:04 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - pediatric18040097 [pii] AID - pediatrrep-18-00097 [pii] AID - 10.3390/pediatric18040097 [doi] PST - epublish SO - Pediatr Rep. 2026 Jul 13;18(4):97. doi: 10.3390/pediatric18040097. PMID- 42496395 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260724 LR - 20260813 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 11 IP - 3 DP - 2026 Jun 27 TI - Concurrent and Construct Validity of the Diagnoform((R)) Kid Physical Fitness Test Battery in Primary School Children. LID - 10.3390/jfmk11030256 [doi] LID - 256 AB - Background: Physical Fitness (PF) is an important health marker that should be regularly monitored with simple, time-efficient test batteries such as Diagnoform((R)) Kid. However, its validity remains insufficiently evaluated. Therefore, this cross-sectional study examined its concurrent and construct validity against a battery of established reference tests. Methods: 184 children were grouped by age (6-7, 8-9 and 10-11 years). The Diagnoform((R)) and reference batteries assessed identical PF components using the following tests: 6-min shuttle run-walk vs. reduced Cooper for cardiorespiratory fitness, hopscotch vs. quadrant jump for agility, standing broad jump with vs. without execution instructions for power, 5-s sprint vs. 20-m sprint for speed, and simplified fingertip-to-floor vs. sit-and-reach for flexibility. Concurrent validity was examined using bivariate correlations, and construct validity through responsiveness to age and sex. Results: Corresponding tests were significantly correlated for all PF components (p < 0.001), except for agility at 10-11 years (p = 0.094). Agility showed moderate correlations in the younger groups (r = -0.45 to -0.67). Correlations were strong for cardiorespiratory fitness and flexibility (r >/= 0.70). For power and speed, correlations ranged from moderate (power: r >/= 0.61 at 6-7 and 8-9 years; speed: r = 0.58 at 6-7 years) to strong (power: r >/= 0.83 at 10-11 years; speed: r >/= 0.70 at 8-9 and 10-11 years). Age and sex influenced performances in both batteries, except for agility (no sex effect observed) and flexibility (sex effect observed in both batteries, whereas an age effect was found only for boys on the reference test). Conclusions: Despite slightly lower responsiveness of the simplified fingertip-to-floor test to age, findings support the concurrent and construct validity of the Diagnoform((R)) Kid tests. FAU - Barbry, Alexis AU - Barbry A AUID- ORCID: 0000-0003-3991-9420 AD - Laboratoire Lorrain de Psychologie et Neurosciences de la Dynamique des Comportements, Universite de Lorraine, F-57000 Metz, France. FAU - Coquart, Jeremy AU - Coquart J AUID- ORCID: 0000-0001-6515-7736 AD - Unite de Recherche Pluridisciplinaire Sport Sante Societe, University of Lille, University of Artois, University of the Littoral Opal Coast, F-59000 Lille, France. FAU - Verhoeven, Caroline AU - Verhoeven C AUID- ORCID: 0009-0006-8960-9382 AD - Department of Mathematics Education, Faculty of Medicine, Universite libre de Bruxelles, 1070 Brussels, Belgium. FAU - Klass, Malgorzata AU - Klass M AUID- ORCID: 0000-0003-1317-5945 AD - Research Unit in Cardiorespiratory Physiology, Exercise and Nutrition, Faculty of Human Movement Sciences, Universite libre de Bruxelles, 1070 Brussels, Belgium. LA - eng PT - Journal Article DEP - 20260627 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC13398135 OTO - NOTNLM OT - agility OT - cardiorespiratory fitness OT - child OT - muscular power OT - speed COIS- The authors declare no conflicts of interest. EDAT- 2026/07/24 12:37 MHDA- 2026/07/24 12:38 PMCR- 2026/06/27 CRDT- 2026/07/24 10:03 PHST- 2026/06/03 00:00 [received] PHST- 2026/06/25 00:00 [revised] PHST- 2026/06/25 00:00 [accepted] PHST- 2026/07/24 12:38 [medline] PHST- 2026/07/24 12:37 [pubmed] PHST- 2026/07/24 10:03 [entrez] PHST- 2026/06/27 00:00 [pmc-release] AID - jfmk11030256 [pii] AID - jfmk-11-00256 [pii] AID - 10.3390/jfmk11030256 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2026 Jun 27;11(3):256. doi: 10.3390/jfmk11030256. PMID- 42495681 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260903 LR - 20260903 IS - 2475-0328 (Electronic) IS - 2475-0328 (Linking) VI - 10 IP - 5 DP - 2026 Sep TI - Lymphocyte-C-Reactive Protein Ratio as Promising New Marker for Predicting Surgical Site Infection in Children With Ulcerative Colitis. PG - 1586-1593 LID - 10.1002/ags3.70236 [doi] AB - BACKGROUND: Surgical site infection (SSI) is a major complication after ileal pouch-anal anastomosis (IPAA) in pediatric ulcerative colitis (UC), significantly impairing quality of life. The lymphocyte-to-C-reactive protein ratio (LCR), a composite marker of systemic inflammation and immune/nutritional status, has emerged as a potential predictor of postoperative outcomes. This study assessed the utility of preoperative LCR in predicting SSI in pediatric UC. METHODS: We retrospectively reviewed pediatric UC patients who underwent IPAA at Mie University Hospital between 2000 and 2024. Preoperative LCR values were analyzed, and the optimal cutoff for SSI prediction was determined using receiver operating characteristic (ROC) analysis. Multivariate logistic regression was performed to identify independent risk factors. SSI was defined according to CDC criteria within 30 days postoperatively. RESULTS: Among 57 patients, 11 (19.3%) developed SSI. The incidence was higher in three-stage procedures than in two-stage procedures (22.7% vs. 17.1%). In both groups, preoperative LCR was significantly lower in SSI-positive patients. ROC analysis demonstrated good discrimination (AUC: 0.80), with an optimal cutoff of LCR < 5000 (sensitivity: 90.9%, specificity: 71.7%). Multivariate analysis confirmed LCR < 5000 as an independent predictor of SSI (odds ratio [OR]: 6.34, 95% CI: 1.23-48.2, p = 0.027). CONCLUSION: Preoperative LCR is a simple, objective biomarker that reliably predicts SSI risk in pediatric UC patients undergoing IPAA. Incorporating LCR into preoperative risk stratification may enable personalized interventions, including nutritional optimization and tailored prophylaxis, to improve surgical outcomes. CI - (c) 2026 The Author(s). Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterological Surgery. FAU - Koike, Yuhki AU - Koike Y AD - Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan. FAU - Higashi, Koki AU - Higashi K AD - Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan. FAU - Sato, Yuki AU - Sato Y AD - Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan. FAU - Nagano, Yuka AU - Nagano Y AD - Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan. FAU - Shimura, Tadanobu AU - Shimura T AD - Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan. FAU - Kitajima, Takahito AU - Kitajima T AD - Department of Genomic Medicine Mie University Graduate School of Medicine Tsu Mie Japan. FAU - Matsushita, Kohei AU - Matsushita K AD - Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan. FAU - Okita, Yoshiki AU - Okita Y AD - Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan. FAU - Okugawa, Yoshinaga AU - Okugawa Y AD - Department of Genomic Medicine Mie University Graduate School of Medicine Tsu Mie Japan. FAU - Toiyama, Yuji AU - Toiyama Y AD - Department of Gastrointestinal and Pediatric Surgery Mie University Graduate School of Medicine Tsu Mie Japan. LA - eng PT - Journal Article DEP - 20260525 PL - Japan TA - Ann Gastroenterol Surg JT - Annals of gastroenterological surgery JID - 101718062 PMC - PMC13394443 OTO - NOTNLM OT - inflammatory bowel disease OT - lymphocyte C-reactive protein ratio OT - pediatric surgery OT - surgical site infection OT - ulcerative colitis COIS- The authors declare no conflicts of interest. EDAT- 2026/07/24 06:35 MHDA- 2026/07/24 06:36 PMCR- 2026/05/25 CRDT- 2026/07/24 05:07 PHST- 2026/01/07 00:00 [received] PHST- 2026/04/21 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/07/24 06:36 [medline] PHST- 2026/07/24 06:35 [pubmed] PHST- 2026/07/24 05:07 [entrez] PHST- 2026/05/25 00:00 [pmc-release] AID - AGS370236 [pii] AID - 10.1002/ags3.70236 [doi] PST - epublish SO - Ann Gastroenterol Surg. 2026 May 25;10(5):1586-1593. doi: 10.1002/ags3.70236. eCollection 2026 Sep. PMID- 42494750 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260724 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 7 DP - 2026 Jul TI - The Effect of Screen Exposure and Early Language Stimulation on Language and Social Development of Children. PG - e113133 LID - 10.7759/cureus.113133 [doi] LID - e113133 AB - Introduction Excessive screen exposure during infancy and early childhood is linked to delayed language and social milestones. Prospective observational data regarding how natural, self-selected variations in screen reduction and caregiver-led language stimulation impact real-world milestones development remain limited. Aims and objectives The aim of this study is to prospectively evaluate the association between changes in screen exposure and caregiver language stimulation on language and social development in nine- to 18-month-old children who were initially exposed to excessive screen time. Methodology In this prospective cohort study, 72 children aged 9-18 months with a baseline screen exposure of more than two hours/day were followed up in a tertiary care hospital. During the six-month follow-up, we did not implement interventions or prescribe treatments but rather observed families and stratified them into two exposure cohorts based on validated monthly lifestyle diaries: Cohort A (spontaneous screen reduction to less than one hour/day plus natural early language stimulation by "serve-and-return" interactions, n=36): and Cohort B (spontaneous screen reduction only without structured language stimulation routines, n=36). Development was assessed using the Language Evaluation Scale Trivandrum (LEST) and Home Screen Questionnaire (HSQ) at baseline and at six months. We used multivariable linear regression to adjust for baseline confounders, including parental education and household socioeconomic status. Results At six-month follow-up, Cohort A infants had a significantly greater mean increase in overall LEST+HSQ scores than Cohort B (+16.3 vs. +7.4, p<0.001). After controlling for baseline demographics, Cohort A had significantly higher language scores in the independent domain (30.2+/-3.4 vs. 24.8+/-3.9, p<0.001) and social communication scores (28.2+/-3.1 vs. 24.4+/-3.5, p<0.001) than Cohort B. Conclusions Combining natural caregiver interaction with structured language stimulation and reduced screen time is much more associated with better language and social development outcomes than reducing screen time alone. Clinicians should emphasize the promotion of increased caregiver interaction during early childhood along with screen time restriction rather than screen restriction alone. CI - Copyright (c) 2026, Vijayakumar et al. FAU - Vijayakumar, Vimalraj AU - Vijayakumar V AD - Department of Pediatrics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND. FAU - T, Arunkumar AU - T A AD - Department of Pediatrics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND. FAU - R, Karthick Prasaad AU - R KP AD - Department of Pediatrics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND. FAU - Rangaraj, Suresh AU - Rangaraj S AD - Department of Pediatrics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND. FAU - K, Sridharini AU - K S AD - Department of Pediatrics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND. FAU - G, Hariharan AU - G H AD - Department of Pediatrics, SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu, IND. LA - eng PT - Journal Article DEP - 20260721 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13394589 OTO - NOTNLM OT - early language stimulation OT - language development OT - pediatric screen time OT - screen exposure OT - social development COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee - SRM Medical College Hospital issued approval SRMIEC-ST1225-6001. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/07/24 06:35 MHDA- 2026/07/24 06:36 PMCR- 2026/07/21 CRDT- 2026/07/24 04:58 PHST- 2026/07/21 00:00 [accepted] PHST- 2026/07/24 06:36 [medline] PHST- 2026/07/24 06:35 [pubmed] PHST- 2026/07/24 04:58 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - 10.7759/cureus.113133 [doi] PST - epublish SO - Cureus. 2026 Jul 21;18(7):e113133. doi: 10.7759/cureus.113133. eCollection 2026 Jul. PMID- 42494209 OWN - NLM STAT- MEDLINE DCOM- 20260914 LR - 20260914 IS - 1469-1833 (Electronic) IS - 1352-4658 (Linking) VI - 54 IP - 2 DP - 2026 Jun TI - Brief, early, and effective: evaluating CBT-T outcomes and change trajectories in a no-minimum threshold to access an eating disorder service. PG - 134-146 LID - 10.1017/S1352465826101350 [doi] AB - OBJECTIVE: Cognitive Behavioural Therapy-Ten (CBT-T) offers a briefer manualised approach to treatment of non-underweight eating disorders (EDs) compared with traditional therapy models, and has the potential to help services deliver timely access to care. This study evaluated CBT-T outcomes in a naturalistic setting, with a focus on session-by-session change patterns. METHOD: A total of 151 young adults received CBT-T in a no-threshold-to-access community ED service. Symptom trajectories were assessed using the ED-15 global scale and subscales (eating concern, weight/shape concern). Using intent-to-treat principle, linear mixed-effect models evaluated treatment effectiveness, and chi-squared and receiver operating characteristic (ROC) analyses explored associations between early symptom change and end-of-treatment remission. RESULTS: Treatment led to significant reductions in ED symptoms and psychosocial impairment, with large effect sizes. Reliable improvement in Weight/Shape Concern - but not Eating Concern - on ED-15 at session 4 significantly predicted ED symptom scores below the clinical cut-off at the last session. CONCLUSIONS: CBT-T is effective in reducing ED symptoms in young adults with non-underweight EDs. While engagement and progress prior to session 4 have been used to guide treatment planning, as stated in the treatment manual, only the change in weight/shape concern at session 4 appeared to be strongly predictive of outcome in this sample, whereas change in eating concern did not. Early changes in weight and shape concerns at initial sessions may be informative in predicting treatment outcome. The findings can support the future development of CBT-T and other brief ED interventions. FAU - Yim, See Heng AU - Yim SH AUID- ORCID: 0000-0002-2241-1017 AD - Department of Psychology, The University of Hong Kong, Hong Kong. ROR: https://ror.org/02zhqgq86 AD - Central and North West London NHS Foundation Trust, UK. ROR: https://ror.org/05drfg619 FAU - Dore, Eve AU - Dore E AD - Central and North West London NHS Foundation Trust, UK. ROR: https://ror.org/05drfg619 FAU - King, Emily AU - King E AD - Central and North West London NHS Foundation Trust, UK. ROR: https://ror.org/05drfg619 FAU - Bloomfield, Ronelle AU - Bloomfield R AD - Central and North West London NHS Foundation Trust, UK. ROR: https://ror.org/05drfg619 FAU - Malecka, Zuzanna AU - Malecka Z AD - Central and North West London NHS Foundation Trust, UK. ROR: https://ror.org/05drfg619 FAU - Fialko, Laura AU - Fialko L AD - Central and North West London NHS Foundation Trust, UK. ROR: https://ror.org/05drfg619 LA - eng PT - Journal Article DEP - 20260724 PL - United States TA - Behav Cogn Psychother JT - Behavioural and cognitive psychotherapy JID - 9418292 SB - IM MH - Humans MH - *Cognitive Behavioral Therapy/methods MH - *Feeding and Eating Disorders/therapy/psychology MH - Female MH - Young Adult MH - Male MH - Treatment Outcome MH - Adult MH - Adolescent OTO - NOTNLM OT - cognitive behavioural therapy OT - eating disorder OT - mechanisms of change OT - service delivery OT - young adults EDAT- 2026/07/24 06:35 MHDA- 2026/09/14 11:41 CRDT- 2026/07/24 03:03 PHST- 2026/09/14 11:41 [medline] PHST- 2026/07/24 06:35 [pubmed] PHST- 2026/07/24 03:03 [entrez] AID - S1352465826101350 [pii] AID - 10.1017/S1352465826101350 [doi] PST - ppublish SO - Behav Cogn Psychother. 2026 Jun;54(2):134-146. doi: 10.1017/S1352465826101350. Epub 2026 Jul 24. PMID- 42494086 OWN - NLM STAT- MEDLINE DCOM- 20260724 LR - 20260813 IS - 1365-2834 (Electronic) IS - 0966-0429 (Print) IS - 0966-0429 (Linking) VI - 2026 IP - 1 DP - 2026 TI - An Equation to Estimate PICC Catheter Length in Very Low Birth Weight Infants. PG - e2067769 LID - 10.1155/jonm/2067769 [doi] LID - 2067769 AB - OBJECTIVE: Peripherally inserted central catheters (PICCs) are essential for very low birth weight infants (VLBWIs), but optimal insertion depth remains challenging. Existing estimation methods often yield suboptimal accuracy. This study aimed to develop and validate anthropometric parameter-based formulas to predict lower extremity PICC insertion depth using the first popliteal crease as an anatomical landmark in VLBWI, seeking to improve first-attempt success rates and procedural safety. METHODS: A prospective study was conducted in a tertiary NICU, enrolling 329 VLBWIs who underwent lower limb PICC insertion between May 2023 and May 2024. Data collected included sex, target vein for catheterization, body weight, length, head circumference at insertion, and vertical distance from the puncture site to the first popliteal crease. Pearson correlation and linear regression analyses were performed to examine associations between anthropometric parameters and optimal catheter length. Univariate prediction formulas (weight-based, length-based, and head circumference-based models) and multivariate regression models were established. Bland-Altman analysis was used to validate model agreement. RESULTS: Univariate regression analysis yielded the following: weight-based model: total insertion depth (cm) = [8.31 + (5 x body weight [kg])] +/- PS-PTC distance, where "+" applies when the puncture site is distal to the popliteal crease and "-" applies when proximal; 8.31 is the regression intercept and five is the regression slope coefficient. Length-based model: total insertion depth (cm) = [1.13 + (0.35 x body length [cm])] +/- PS-PTC distance; 1.13 is the intercept and 0.35 is the slope coefficient. Head circumference-based model: total insertion depth (cm) = [2.33 + (0.43 x head circumference [cm])] +/- PS-PTC distance; 2.33 is the intercept and 0.43 is the slope coefficient. Multivariate regression analysis established four combination models, with Model IV (weight + length + head circumference) showing optimal performance. CONCLUSION: Anthropometric parameter-based prediction formulas provide precise guidance for lower extremity PICC placement in VLBWI, enhancing placement success and safety. This approach supports individualized care and is especially valuable where ultrasound guidance is limited. CI - Copyright (c) 2026 Jiaxin Li et al. Journal of Nursing Management published by John Wiley & Sons Ltd. FAU - Li, Jiaxin AU - Li J AUID- ORCID: 0009-0004-5307-6807 AD - Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China. FAU - Dong, Yubing AU - Dong Y AD - Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University, Shenzhen, Guangdong, China, fimmu.com. FAU - Yu, Qingling AU - Yu Q AD - Guangzhou University of Chinese Medicine, Guangzhou, China, gzucm.edu.cn. FAU - Cao, Aifen AU - Cao A AD - Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University, Shenzhen, Guangdong, China, fimmu.com. FAU - Jiang, Shan AU - Jiang S AD - Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University, Shenzhen, Guangdong, China, fimmu.com. FAU - Huang, Yinsui AU - Huang Y AD - Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University, Shenzhen, Guangdong, China, fimmu.com. FAU - Xiong, Xiaoyun AU - Xiong X AD - Shenzhen Maternity and Child Healthcare Hospital, Women and Children's Medical Center, Southern Medical University, Shenzhen, Guangdong, China, fimmu.com. LA - eng GR - SZGSP009/Guangdong Provincial High-level Clinical Key Specialty Project/ GR - JCYJ20250604191408012/Natural Science Foundation of Shenzhen Municipality/ GR - JCYJ20230807120213026/Shenzhen Science and Technology Innovation Program/ GR - JCYJ20240813115035045/Shenzhen Science and Technology Innovation Program/ GR - FYB2022004/Research Fund of Shenzhen Maternity & Child Healthcare Hospital/ GR - SZSM202211001/Shenzhen "Sanming" Project of Medicine/ GR - ZDSYS20230626091559006/Key Laboratory for Pregnancy Disorders and Maternal and Child Health of Shenzhen/ GR - 2025FYH21/National Health Commission of the People's Republic of China/ PT - Journal Article PL - England TA - J Nurs Manag JT - Journal of nursing management JID - 9306050 SB - IM MH - Humans MH - *Infant, Very Low Birth Weight/physiology MH - Prospective Studies MH - Female MH - *Catheterization, Peripheral/methods/standards/instrumentation/statistics & numerical data MH - Infant, Newborn MH - Male PMC - PMC13396696 COIS- The authors declare no conflicts of interest. EDAT- 2026/07/24 06:35 MHDA- 2026/07/24 06:36 PMCR- 2026/07/23 CRDT- 2026/07/24 01:52 PHST- 2026/05/17 00:00 [revised] PHST- 2025/07/18 00:00 [received] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/07/24 06:36 [medline] PHST- 2026/07/24 06:35 [pubmed] PHST- 2026/07/24 01:52 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - JONM2067769 [pii] AID - 10.1155/jonm/2067769 [doi] PST - ppublish SO - J Nurs Manag. 2026;2026(1):e2067769. doi: 10.1155/jonm/2067769. PMID- 42493851 OWN - NLM STAT- MEDLINE DCOM- 20260928 LR - 20260930 IS - 1440-1754 (Electronic) IS - 1034-4810 (Print) IS - 1034-4810 (Linking) VI - 62 IP - 9 DP - 2026 Sep TI - Investigating the Relationship Between Sensory Processing, Pain and Toe Walking Gait: A Survey Study. PG - 1682-1692 LID - 10.1111/jpc.70504 [doi] AB - AIM: This study aimed to examine sensory processing patterns, the frequency and impact of parent-reported pain in children who toe walk across a range of diagnoses using validated caregiver-report tools. METHODS: An online cross-sectional survey was distributed internationally between July 2024 and March 2025. Parents of children who toe walk aged 3-14 years, regardless of diagnosis, completed the Short Sensory Profile (SSP) and the Child Activity Limitations Interview-9 (CALI-9). RESULTS: The survey collected responses from 176 parents of 187 children with toe walking gait. Sensory processing challenges were frequently reported, particularly in children with autism spectrum disorder (98%). Nearly half (48% of 187) of children were reported to experience pain, most frequently in the feet/ankles, lower legs, and hips/thighs. Most parents (94%) and their child's medical professional (81%) attributed their child's pain to toe walking. Parents of children experiencing pain described significantly greater limitations in activities such as sports (OR 3.10, p < 0.001), running (OR 3.46, p < 0.001), and social participation (OR 2.43, p < 0.001). CONCLUSION: Sensory processing differences and pain were frequently reported among children who toe walk in this sample. Routine assessment of sensory processing and pain in clinical practice may guide targeted interventions to improve participation, function, and quality of life. CI - (c) 2026 The Author(s). Journal of Paediatrics and Child Health published by John Wiley & Sons Australia, Ltd on behalf of Paediatrics and Child Health Division (The Royal Australasian College of Physicians). FAU - Donne, Jack H AU - Donne JH AUID- ORCID: 0000-0002-8364-5079 AD - School of Primary and Allied Health Care, Monash University, Melbourne, Victoria, Australia. FAU - Pacey, Verity AU - Pacey V AD - School of Health Sciences and Nursing, Macquarie University, Sydney, New South Wales, Australia. FAU - Polt, Desiree AU - Polt D AD - Parent Team Member, Junction City, Kansas, USA. FAU - Powell, Jennifer A AU - Powell JA AD - School of Medicine, The University of Queensland, Brisbane, Australia. FAU - Fahey, Michael C AU - Fahey MC AUID- ORCID: 0000-0003-0811-4785 AD - Department of Paediatrics, Monash Health, Melbourne, Victoria, Australia. AD - Department of Medicine, Monash University, Melbourne, Victoria, Australia. FAU - Williams, Cylie M AU - Williams CM AUID- ORCID: 0000-0002-0223-9141 AD - School of Primary and Allied Health Care, Monash University, Melbourne, Victoria, Australia. LA - eng PT - Journal Article DEP - 20260723 PL - Australia TA - J Paediatr Child Health JT - Journal of paediatrics and child health JID - 9005421 SB - IM MH - Humans MH - Child MH - Cross-Sectional Studies MH - Female MH - Adolescent MH - Male MH - Child, Preschool MH - *Toes MH - Surveys and Questionnaires MH - *Pain/physiopathology MH - *Gait/physiology MH - *Walking/physiology MH - Parents PMC - PMC13617236 OAB - Emerging evidence suggests that toe walking gait in children may be related to disrupted sensory processing abilities. Parents in this study frequently reported sensory processing challenges among children who toe walked, regardless of the reason for toe walking. Limited research has examined the prevalence or impact of pain in children who toe walk. In this study, almost half of the children were reported to experience pain, which was associated with limitations in activities such as sports, running, and social participation. Routine assessment of sensory processing and pain in clinical practice may guide targeted interventions aiming to improve participation, function, and quality of life. OABL- eng OTO - NOTNLM OT - paediatrics OT - pain OT - sensory processing OT - survey OT - toe walking COIS- The authors declare no conflicts of interest. EDAT- 2026/07/24 06:35 MHDA- 2026/09/28 05:33 PMCR- 2026/09/28 CRDT- 2026/07/24 00:13 PHST- 2026/06/23 00:00 [revised] PHST- 2026/03/02 00:00 [received] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/09/28 05:33 [medline] PHST- 2026/07/24 06:35 [pubmed] PHST- 2026/07/24 00:13 [entrez] PHST- 2026/09/28 00:00 [pmc-release] AID - JPC70504 [pii] AID - 10.1111/jpc.70504 [doi] PST - ppublish SO - J Paediatr Child Health. 2026 Sep;62(9):1682-1692. doi: 10.1111/jpc.70504. Epub 2026 Jul 23. PMID- 42492475 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260813 IS - 1872-7654 (Electronic) IS - 0301-2115 (Linking) VI - 325 DP - 2026 Sep TI - Association between first-trimester PAPP-A and large-for-gestational-age neonates in non-diabetic pregnancies: An exploratory cohort study. PG - 115308 LID - S0301-2115(26)00376-3 [pii] LID - 10.1016/j.ejogrb.2026.115308 [doi] AB - OBJECTIVE: To evaluate the predictive value of elevated first-trimester pregnancy-associated plasma protein-A (PAPP-A) for large-for-gestational-age (LGA) neonates in non-diabetic pregnancies, and to investigate its potential modifying effect on classical fetal-growth-restricting factors. METHODS: This retrospective cohort study analysed 563 normoglycaemic pregnancies, with strict exclusion of patients with gestational or pregestational diabetes. Participants were stratified by first-trimester PAPP-A percentile into high (>90th percentile, n = 73) and normal ( 90th percentile and continuous multiples of the median (MoM)] were adjusted for maternal age, body mass index, weight gain, smoking status, and fetal gender. Main outcomes included birth weight, LGA (>4000 g), neonatal length, and neonatal intensive care unit admission rate. RESULTS: High PAPP-A was significantly associated with higher mean birth weight (3388.2 +/- 526.4 g vs 3193.1 +/- 538.7 g; p = 0.004) and a 2.4-fold increase in the incidence of LGA (11.0% vs 4.5%; p = 0.044). PAPP-A MoM was positively correlated with neonatal crown-heel length (r = 0.132; p = 0.001). In the continuous multivariate model, every 1-unit increase in PAPP-A MoM was associated with a 1.82-fold increase [95% confidence interval (CI) 1.21-2.72; p = 0.003] in the risk of LGA. Receiver operating characteristic curve analysis showed an area under the curve of 0.665 (95% CI 0.566-0.762), with a high negative predictive value of 95.5% (95% CI 93.3-97.0%) but limited sensitivity (26.7%, 95% CI 14.2-44.4%) and positive predictive value (11.0%, 95% CI 5.7-20.2%). In exploratory subgroup analyses, high PAPP-A was associated with higher birth weight in the presence of factors such as advanced maternal age and limited weight gain. CONCLUSION: In non-diabetic pregnancies, elevated first-trimester PAPP-A is an independent correlate of fetal overgrowth. As a potential marker of increased free insulin-like growth factor bioavailability, high PAPP-A may reflect an anabolic signal that warrants further investigation in multiparametric prediction models. Its clinical utility as a standalone screening tool is currently limited by low sensitivity and a positive predictive value; therefore, its role remains to be established in larger prospective trials. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Karakaya, Turan Kaan AU - Karakaya TK AD - Department of Obstetrics and Gynaecology, Faculty of Medicine, Giresun University, Giresun, Turkey. Electronic address: kaan.karakaya@giresun.edu.tr. FAU - Arslan, Hilmi Furkan AU - Arslan HF AD - Department of Medical Biochemistry, Faculty of Medicine, Giresun University, Giresun, Turkey. LA - eng PT - Journal Article DEP - 20260716 PL - Ireland TA - Eur J Obstet Gynecol Reprod Biol JT - European journal of obstetrics, gynecology, and reproductive biology JID - 0375672 RN - EC 3.4.24.- (Pregnancy-Associated Plasma Protein-A) RN - EC 3.4.24.79 (PAPPA protein, human) SB - IM MH - Humans MH - Female MH - *Pregnancy-Associated Plasma Protein-A/metabolism/analysis MH - Pregnancy MH - *Pregnancy Trimester, First/blood MH - *Infant, Large for Gestational Age MH - Retrospective Studies MH - Adult MH - Infant, Newborn MH - *Fetal Macrosomia/blood MH - Birth Weight MH - Predictive Value of Tests OTO - NOTNLM OT - Fetal macrosomia OT - Insulin-like growth factor (IGF) OT - Large for gestational age (LGA) OT - Pregnancy-associated plasma protein-A (PAPP-A) OT - Prenatal screening COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/24 00:37 MHDA- 2026/08/13 23:36 CRDT- 2026/07/23 18:11 PHST- 2026/03/04 00:00 [received] PHST- 2026/05/20 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/08/13 23:36 [medline] PHST- 2026/07/24 00:37 [pubmed] PHST- 2026/07/23 18:11 [entrez] AID - S0301-2115(26)00376-3 [pii] AID - 10.1016/j.ejogrb.2026.115308 [doi] PST - ppublish SO - Eur J Obstet Gynecol Reprod Biol. 2026 Sep;325:115308. doi: 10.1016/j.ejogrb.2026.115308. Epub 2026 Jul 16. PMID- 42492456 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260828 IS - 1532-2688 (Electronic) IS - 1059-1311 (Linking) VI - 141 DP - 2026 Sep TI - Predicting the efficacy of classic ketogenic diet therapy in children with refractory epilepsy using dynamic changes in the glucose-ketone index (GKI). PG - 137-142 LID - S1059-1311(26)00208-6 [pii] LID - 10.1016/j.seizure.2026.07.011 [doi] AB - OBJECTIVE: To investigate the predictive value of dynamic changes in blood glucose, blood ketones and glucose-ketone index (GKI) for the efficacy of the classic ketogenic diet (CKD)in children with refractory epilepsy. METHODS: Data from 189 children with refractory epilepsy who received classic ketogenic diet (CKD) between January 2018 and December 2024 were retrospectively analyzed. Blood glucose, blood ketones and the glucose-ketone index (GKI) which defined as the ratio of blood glucose to blood ketone were monitored at multiple time points, from the 2-day period of halving carbohydrate intake to 90 days after CKD initiation. Patients were divided into a responder group (>/=50% seizure reduction) and a non-responder group based on Engel's classification after three months of treatment. Group differences in metabolic indices were assessed, and receiver operating characteristic (ROC) analysis identified optimal GKI thresholds for predicting response. RESULTS: On the first day of CKD therapy, GKI (AUC = 0.638) was the best single predictor of efficacy among all time points, with a cut-off value of 9.63 (sensitivity and specificity both 0.63). Combining blood glucose (<4.95 mmol/L) and blood ketone (>0.75 mmol/L) levels improved predictive performance (AUC = 0.661). CONCLUSION: A GKI > 9.63 on the first day of CKD therapy may serve as an early-warning indicator of poor treatment response. The early treatment phase-from the second day of halving carbohydrate intake to the first day of CKD-represents a critical window for metabolic transition. Monitoring dynamic changes in GKI and blood ketone may facilitate timely adjustment of intervention strategies. CI - Copyright (c) 2026 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. FAU - Li, Jiang AU - Li J AD - Changsha Hospital for Maternal & Child Health Care Affiliated to Hunan Normal University, Changsha, 410007, China. FAU - Wang, Tianqi AU - Wang T AD - Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. FAU - Yu, Lifei AU - Yu L AD - Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. Electronic address: yulf_ek@fudan.edu.cn. FAU - Ni, Yan AU - Ni Y AD - Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. FAU - Li, Yijie AU - Li Y AD - Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. FAU - Zhang, Yunjian AU - Zhang Y AD - Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. FAU - Zhou, Shuizhen AU - Zhou S AD - Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. FAU - Wang, Yi AU - Wang Y AD - Department of Neurology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. LA - eng PT - Journal Article DEP - 20260712 PL - England TA - Seizure JT - Seizure JID - 9306979 RN - 0 (Ketones) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - *Diet, Ketogenic/methods MH - *Drug Resistant Epilepsy/diet therapy/blood MH - *Ketones/blood MH - Female MH - *Blood Glucose/metabolism MH - Retrospective Studies MH - Male MH - Child MH - Treatment Outcome MH - Child, Preschool MH - Adolescent OTO - NOTNLM OT - Blood ketone OT - CKD OT - Children with refractory epilepsy OT - Classic ketogenic diet OT - Efficacy prediction OT - GKI COIS- Declaration of competing interest All authors declare no competing interests. EDAT- 2026/07/24 00:37 MHDA- 2026/08/28 23:34 CRDT- 2026/07/23 18:10 PHST- 2026/04/26 00:00 [received] PHST- 2026/06/18 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/08/28 23:34 [medline] PHST- 2026/07/24 00:37 [pubmed] PHST- 2026/07/23 18:10 [entrez] AID - S1059-1311(26)00208-6 [pii] AID - 10.1016/j.seizure.2026.07.011 [doi] PST - ppublish SO - Seizure. 2026 Sep;141:137-142. doi: 10.1016/j.seizure.2026.07.011. Epub 2026 Jul 12. PMID- 42492233 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261014 IS - 1530-0315 (Electronic) IS - 0195-9131 (Linking) VI - 58 IP - 11 DP - 2026 Nov 1 TI - Resting Metabolic Rate in Collegiate Male Wrestlers: Cross-Validation and Development of Prediction Equations. PG - 2524-2534 LID - 10.1249/MSS.0000000000004071 [doi] AB - PURPOSE: The purpose of the current study was to cross-validate previously developed resting metabolic rate (RMR) prediction equations using laboratory measurements of RMR as a criterion. METHODS: National Collegiate Athletic Association Division I (n = 60) and III (n = 113) male wrestlers participated in the current study (n = 173; Age: 19.6 +/- 1.5 yrs.; Height: 176.3 +/- 6.3 cm; Weight: 76.6 +/- 10.9 kg; Body Fat: 11.4 +/- 3.0%). Indirect calorimetry was used to measure RMR and Skinfold thickness was used to estimate body fat percentage (BF%) during the preseason period under standardized dress (underwear only), fasting, and resting conditions. RESULTS: Mean measured RMR was 2102 +/- 341 kcal.d -1 . All body mass-based RMR prediction equations significantly underestimated the measured RMR, with the exception of the Jagim and Schofield equations. The Tinsley fat-free mass (FFM) equation and the Cunningham equation had the lowest constant error values when compared with measured RMR (mean bias +/- standard error: 80 +/- 20 kcal and 126 +/- 20 kcal.d -1 , respectively). Linear regression indicated the Tinsley FFM (R 2 = 0.422, root-mean-squared error (RMSE) = 279 kcals, %RMSE = 13.3%), and Cunningham FFM equations had the closest agreement to measured RMR (R 2 = 0.422, RMSE = 301 kcals, %RMSE = 14.3%), along with the Jagim equation for a body mass-based prediction equation (R 2 = 0.377, RMSE = 338 kcals, %RMSE = 16.1%). The standard error of the estimate (SEE) ranged from 260 to 272 kcal.d -1 across equations. Coefficients of determination (R 2 ) ranged from 37% to 42%. The new body mass and FFM-based equations exhibited good agreement based on the constant error (26 and -13 kcal.d -1 ), RMSE (274 and 252 kcal.d -1 ), respectively. CONCLUSIONS: The newly developed equations demonstrated mean bias <2% of measured RMR. CI - Copyright (c) 2026 by the American College of Sports Medicine. FAU - Jagim, Andrew R AU - Jagim AR AD - Health Professions, University of Wisconsin-La Crosse, La Crosse, WI. AD - Intercollegiate Athletics, Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, George Mason University, Fairfax, VA. FAU - Dobbs, Ward C AU - Dobbs WC AD - Division of Kinesiology and Health, University of Wyoming, Laramie, WY. FAU - Magee, Meghan K AU - Magee MK AD - Exercise Science and Exercise Physiology, Kent State University, Kent, OH. FAU - Fields, Jennifer B AU - Fields JB AD - Intercollegiate Athletics, Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, George Mason University, Fairfax, VA. AD - Nutritional Sciences, University of Connecticut, Storrs, CT. FAU - Sims, Jesse N L AU - Sims JNL AD - Exercise Science and Exercise Physiology, Kent State University, Kent, OH. FAU - Saine, Noelle D AU - Saine ND AD - Intercollegiate Athletics, Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, George Mason University, Fairfax, VA. AD - Sport, Recreation, and Tourism Management, George Mason University, Manassas, VA. FAU - Jones, Margaret T AU - Jones MT AD - Intercollegiate Athletics, Patriot Performance Laboratory, Frank Pettrone Center for Sports Performance, George Mason University, Fairfax, VA. AD - Sport, Recreation, and Tourism Management, George Mason University, Manassas, VA. LA - eng PT - Journal Article PT - Validation Study DEP - 20260703 PL - United States TA - Med Sci Sports Exerc JT - Medicine and science in sports and exercise JID - 8005433 SB - IM MH - Humans MH - *Basal Metabolism/physiology MH - *Wrestling/physiology MH - Male MH - Calorimetry, Indirect MH - Young Adult MH - Skinfold Thickness MH - Body Composition MH - Prediction Methods, Machine MH - Adolescent MH - Body Mass Index OTO - NOTNLM OT - BODY COMPOSITION OT - ENERGY REQUIREMENTS OT - METABOLISM OT - WEIGHT MANAGEMENT OT - WRESTLING EDAT- 2026/07/24 00:37 MHDA- 2026/10/14 05:33 CRDT- 2026/07/23 18:03 PHST- 2026/10/14 05:33 [medline] PHST- 2026/07/24 00:37 [pubmed] PHST- 2026/07/23 18:03 [entrez] AID - 00005768-990000000-01108 [pii] AID - 10.1249/MSS.0000000000004071 [doi] PST - ppublish SO - Med Sci Sports Exerc. 2026 Nov 1;58(11):2524-2534. doi: 10.1249/MSS.0000000000004071. Epub 2026 Jul 3. PMID- 42491911 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260813 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Associations between echocardiographic parameters and aerobic performance in young athletes. PG - e21263 LID - 10.7717/peerj.21263 [doi] LID - e21263 AB - BACKGROUND AND OBJECTIVES: Cardiac morphology can be shaped according to chronic and acute exercise and provides important findings regarding cardiac response to different types of performance. However, cardiac remodelling is a multidimensional process involving intertwined structural, functional, and haemodynamic components, making it difficult to explain with a single criterion and requiring a comprehensive assessment. The aim of this study is to investigate the effects of echocardiographic (ECHO) parameters on 30-15 interval fitness test (IFT) performance. MATERIALS AND METHODS: Twenty-three active athletes participated in the study. All ECHO measurements were performed by a specialist cardiologist using standard clinical methods, and the IFT was administered to participants after the measurements. In the analysis, ECHO variables representing the structural characteristics of the left ventricle, systolic-diastolic function, and aortic/atrial measurements were evaluated, with priority given to parameters indexed according to body surface area (BSA). Relationships between IFT performance and ECHO parameters were examined by establishing parsimonious linear regression models appropriate for small sample sizes; models were evaluated using Akaike Information Criterion (AICc)-based model comparison and model averaging, results were checked for robustness using leave-one-out cross-validation (LOOCV), and the SHapley Additive exPlanations (SHAP) approach, consistent with the model, was used for interpretability. RESULTS: In the AICc-based model comparison, the parsimonious model with the highest support consisted of the body composition (BMI) + posterior wall (PW)_I + aortic strain (AORT_STR) components and explained approximately 46% of the variance in IFT performance (mean adj. R (2) = 0.461; LOOCV root mean squared error (RMSE) = 1.811; mean DeltaAICc = 0; mean Akaike weight = 0.0476). Variable importance analyses in the best model set revealed that the variables most consistently associated with IFT were BMI (Sigmaw = 0.46; weighted mean-SHAP- = 0.154; beta = - 0.068) and posterior wall thickness indexed by BSA (PW_I) (Sigmaw = 0.35; weighted mean-SHAP- = 0.211; beta = 0.348). This was followed by IVS_I (Sigmaw = 0.191; weighted mean-SHAP- = 0.072; beta = 0.124), A wave (Sigmaw = 0.177; weighted mean-SHAP- = 0.080; beta = 0.849) and AORT_STR (Sigmaw = 0.166; weighted mean-SHAP- = 0.077; beta = 0.013) followed. Overall, the distribution of model weights across multiple models indicated significant model uncertainty, while BMI and indexed structural measures provided the strongest and most consistent signal in relation to IFT. CONCLUSIONS: In this context, it has been concluded that body composition is also a determining factor in the relationship between cardiac morphology and IFT performance. Large prospective studies are important for determining this complex relationship. CI - (c)2026 Akgumus et al. FAU - Akgumus, Alkame AU - Akgumus A AD - Department of Cardiology, Medical Faculty, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Kurtoglu, Ahmet AU - Kurtoglu A AD - Department of Coaching Education, Faculty of Sport Science, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Ozer, Omer AU - Ozer O AD - Department of Physical Education and Sport Teaching, Faculty of Sport Science, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Duygu, Ali AU - Duygu A AD - Department of Cardiology, Medical Faculty, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Car, Bekir AU - Car B AD - Department of Physical Education and Sport Teaching, Faculty of Sport Science, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Kurtoglu, Ertugrul AU - Kurtoglu E AD - Department of Cardiology, Medical Faculty, Malatya Turgut Ozal University, Malatya, Turkey. FAU - Uzgur, Kamil AU - Uzgur K AD - Department of Coaching Education, Faculty of Sport Science, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Er, Fahri AU - Er F AD - Department of Cardiology, Medical Faculty, Bandirma Onyedi Eylul University, Balikesir, Turkey. FAU - Muracki, Jaroslaw AU - Muracki J AD - Institute of Physical Culture Sciences, Department of Physical Culture and Health, University of Szczecin, Szczecin, Poland. FAU - Elkholi, Safaa M AU - Elkholi SM AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260714 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - *Echocardiography MH - Male MH - *Athletes MH - Young Adult MH - Female MH - *Exercise/physiology MH - Adolescent MH - Ventricular Function, Left/physiology MH - Exercise Test MH - Heart Ventricles/diagnostic imaging MH - *Athletic Performance/physiology PMC - PMC13378464 OTO - NOTNLM OT - Aerobic performance OT - Cardiac function OT - Cardiac morphology OT - Echocardiography COIS- The authors declare there are no competing interests. EDAT- 2026/07/23 18:35 MHDA- 2026/07/23 18:36 PMCR- 2026/07/14 CRDT- 2026/07/23 16:18 PHST- 2025/10/03 00:00 [received] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/07/23 18:36 [medline] PHST- 2026/07/23 18:35 [pubmed] PHST- 2026/07/23 16:18 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 21263 [pii] AID - 10.7717/peerj.21263 [doi] PST - epublish SO - PeerJ. 2026 Jul 14;14:e21263. doi: 10.7717/peerj.21263. eCollection 2026. PMID- 42491750 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260813 IS - 2214-9996 (Electronic) IS - 2214-9996 (Linking) VI - 92 IP - 1 DP - 2026 TI - Implementing a WASH Package Within Prevention of Vertical Transmission of HIV Programming in Lilongwe, Malawi: A Program Evaluation. PG - 64 LID - 10.5334/aogh.5322 [doi] LID - 64 AB - Background: Access to safe drinking water is a considerable problem in Malawi. Contaminated water plays a major role in diarrheal disease, particularly for people living with HIV and their families. Water, sanitation, and hygiene (WASH) interventions can reduce the risk of diarrhea among children by up to 50%. However, few published reports describe WASH integration in routine HIV care programming in Africa. Objective: To evaluate a WASH program integrated within the prevention of vertical transmission of HIV (PVTH) care in Lilongwe, Malawi. Methods: The University of North Carolina's Project Malawi, the Proctor & Gamble Company (P&G), and the Malawi Ministry of Health implemented a safe drinking water program from 2008 to 2023, integrated within the national PVTH program in Lilongwe, Malawi. We provided a point-of-use WASH package to pregnant and breastfeeding women (PBFW) with HIV and their families that included soap, sieves, closed-water containers, and P&G water purification packets. We examine program impact by describing trends in childhood diarrhea and retention in care at 33 program facilities and 29 non-program facilities from 2018 to 2022. Findings: Over the program's final 5 years, an estimated 2 million water purification packets were distributed annually. From 2018 to 2022 in program facilities, non-bloody diarrhea rates among children under 5 years remained constant, while bloody-diarrhea rates fell at both program and non-program facilities. A small association was found between facility participation in the program and retention in care among PBFW living with HIV (incidence rate ratio: 1.05, 95% CI: 0.99-1.12), but of borderline statistical significance. Conclusions: In an environment where access to clean water is not assured, we demonstrated the feasibility of delivering a WASH package in HIV care settings over 15 consecutive years. The collaboration between government, academic, and industry partners provides an example for how to integrate WASH within PVTH programming. CI - Copyright: (c) 2026 The Author(s). FAU - Topazian, Hillary M AU - Topazian HM AUID- ORCID: 0000-0001-7824-9605 AD - University of Utah, Salt Lake City, United States. FAU - Noble, Skyler AU - Noble S AD - University of North Carolina, Chapel Hill, United States. FAU - Mofolo, Innocent AU - Mofolo I AD - UNC Project, Lilongwe, Malawi. FAU - Mwale, Gertrude AU - Mwale G AD - UNC Project, Lilongwe, Malawi. FAU - Phanga, Twambilie AU - Phanga T AD - UNC Project, Lilongwe, Malawi. FAU - Hoffman, Irving F AU - Hoffman IF AD - University of North Carolina, Chapel Hill, United States. AD - UNC Project, Lilongwe, Malawi. FAU - Herce, Michael E AU - Herce ME AD - University of North Carolina, Chapel Hill, United States. AD - UNC Project, Lilongwe, Malawi. LA - eng PT - Journal Article DEP - 20260714 PL - United States TA - Ann Glob Health JT - Annals of global health JID - 101620864 RN - 0 (Drinking Water) RN - 0 (Soaps) SB - IM MH - Humans MH - Malawi/epidemiology MH - *Infectious Disease Transmission, Vertical/prevention & control MH - *HIV Infections/prevention & control/transmission MH - Female MH - Program Evaluation MH - *Sanitation/methods MH - Pregnancy MH - *Hygiene MH - Drinking Water MH - *Diarrhea/prevention & control/epidemiology MH - Infant MH - *Water Purification/methods MH - Water Supply MH - Breast Feeding MH - Soaps MH - Infant, Newborn PMC - PMC13378426 OTO - NOTNLM OT - WASH OT - hygiene OT - prevention of vertical transmission of HIV OT - program implementation OT - sanitation OT - water COIS- The authors have no competing interests to declare. EDAT- 2026/07/23 18:35 MHDA- 2026/07/23 18:36 PMCR- 2026/07/14 CRDT- 2026/07/23 16:14 PHST- 2026/04/21 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/07/23 18:36 [medline] PHST- 2026/07/23 18:35 [pubmed] PHST- 2026/07/23 16:14 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 10.5334/aogh.5322 [doi] PST - epublish SO - Ann Glob Health. 2026 Jul 14;92(1):64. doi: 10.5334/aogh.5322. eCollection 2026. PMID- 42491719 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260723 LR - 20260922 IS - 2632-1297 (Electronic) IS - 2632-1297 (Linking) VI - 8 IP - 4 DP - 2026 TI - Using reference intervals to improve interpretation of youth sport-related concussion biomarkers using a research platform. PG - fcag250 LID - 10.1093/braincomms/fcag250 [doi] LID - fcag250 AB - Youth sports-related concussion (SRC) is a major health concern. Approximately 67% of Canadian youth participate in sports and recreation, and 93% of head injuries experienced in sports and recreation are concussions. SRCs are challenging to diagnose because symptoms are often subtle, which can affect the reliability of clinical diagnostic methods that are often subjective. As undiagnosed concussions can potentially lead to unfavourable neurological implications, objective diagnostic tools have the potential to improve diagnosis and inform prognosis. Recent research has highlighted the potential utility of plasma neurofilament light (NfL) and glial fibrillary acidic protein (GFAP) for SRC diagnosis, offering a quantitative and cost-effective diagnostic method. However, a major gap in the literature is understanding whether the magnitude of change in NfL and GFAP levels post-SRC exceeds normal variation observed at the population level. This study evaluates NfL and GFAP as diagnostic SRC biomarkers by comparing preseason and post-SRC levels measured up to 28 days after injury to population-based reference intervals. Preseason (uninjured) and post-SRC plasma samples from the Surveillance in High Schools and Community Sports to Reduce Concussions and their Consequences study were quantified with Quanterix's Neurology-4-plex-B assay and compared to previously generated age-matched reference interval. A total of 658 preseason specimens (440 male [67%]; median [range] age, 15.9 [10.4-18.4] years) and 134 post-SRC specimens (72 male [54%]; median [range] age, 16.1 [11.2-18.4] years) were assessed. Median biomarker levels were higher at post-SRC than preseason for both NfL (preseason/post-SRC = 5.1/5.5 pg/ml, P = 0.0339) and GFAP (preseason/post-SRC=51.7/59.7 pg/ml, P < 0.0001). However, when compared to population controls across the same age range, 580 (88%) preseason and 119 (89%) of post-SRC measures fell within the reference interval (5th-95th percentile) for NfL and 644 (98%) preseason and 132 (99%) of post-SRC measures fell within the reference interval for GFAP. Further, the number of participants within or above the reference interval (>95th percentile) did not differ between preseason and post-SRC groups for either NfL (P > 0.9999) or GFAP (P > 0.9999). Body mass index was inversely associated with the distribution of NfL (5th-50th/50th-95th = 23.02/22.15, P = 0.0083; 5th-50th/50th-95th = 24.37/21.74, P = 0.0038) and GFAP (5th-50th/50th-95th = 23.12/22.29, P = 0.0219; 5th-50th/50th-95th = 25.03/22.27, P = 0.0025) within the reference interval, which may explain the skew of NfL and GFAP levels in the SHRed participants compared to population controls at both preseason and post-SRC. We conclude that plasma NfL and GFAP measured up to 28 days post-SRC do not meet criteria for clinical significance as stand-alone post-acute diagnostic biomarkers for adolescent SRC. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Guarantors of Brain. FAU - Achalu, Kidus AU - Achalu K AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. FAU - Cooper, Jennifer G AU - Cooper JG AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. FAU - Tabor, Jason B AU - Tabor JB AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Ghodsi, Mohammad AU - Ghodsi M AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. FAU - Huang, Johnny AU - Huang J AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. FAU - Josafatow-Garcia, Nik AU - Josafatow-Garcia N AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Penner, Linden C AU - Penner LC AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Stukas, Sophie AU - Stukas S AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. FAU - Galarneau, Jean-Michel AU - Galarneau JM AUID- ORCID: 0000-0003-3784-8753 AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Fraser, Douglas D AU - Fraser DD AD - Department of Pediatrics and Clinical Neurological Sciences, Western University, London, Ontario N6A 3K7, Canada. FAU - Smirl, Jonathan AU - Smirl J AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Yeates, Keith O AU - Yeates KO AUID- ORCID: 0000-0001-7680-2892 AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Department of Psychology, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Debert, Chantel T AU - Debert CT AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Department of Clinical Neurosciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Emery, Carolyn A AU - Emery CA AD - Faculty of Kinesiology, Sport Injury Prevention Research Centre, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta T2N 1N4, Canada. AD - Departments of Pediatrics and Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 1N4, Canada. FAU - Wellington, Cheryl L AU - Wellington CL AD - Djavad Mowafaghian Centre for Brain Health, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - School of Biomedical Engineering, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. AD - International Collaboration on Repair Discoveries, University of British Columbia, Vancouver, British Columbia V6T 1Z3, Canada. LA - eng PT - Journal Article DEP - 20260705 PL - England TA - Brain Commun JT - Brain communications JID - 101755125 PMC - PMC13378169 OTO - NOTNLM OT - blood-based biomarkers OT - concussion OT - context of use OT - normative data COIS- Cheryl Wellington is principal investigator on unrelated operating grants from the Canadian Institutes of Health Research, Weston Brain Institutes, Cure Alzheimer Fund, US Department of Defence, and the National Institutes of Health. Keith Owen Yeates is principal investigator on a grant from the Canada Foundation for Innovation; co-investigator on grants from the Canadian Institutes of Health Research, Brain Canada Foundation, and Ontario Brain Institute; a paid research consultant for the Research Institute at Nationwide Children's Hospital, Columbus, OH, USA; receives book royalties from Guilford Press and Cambridge University Press; has received travel support and honorariums for presentations to multiple organizations; and serves on the Data Safety and Monitoring Board for the Concussion Health Improvement Program (CHIP) Trial, University of Washington. All other authors report no competing interests. EDAT- 2026/07/23 18:34 MHDA- 2026/07/23 18:35 PMCR- 2026/07/05 CRDT- 2026/07/23 16:13 PHST- 2025/05/02 00:00 [received] PHST- 2026/04/23 00:00 [revised] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/07/23 18:35 [medline] PHST- 2026/07/23 18:34 [pubmed] PHST- 2026/07/23 16:13 [entrez] PHST- 2026/07/05 00:00 [pmc-release] AID - fcag250 [pii] AID - 10.1093/braincomms/fcag250 [doi] PST - epublish SO - Brain Commun. 2026 Jul 5;8(4):fcag250. doi: 10.1093/braincomms/fcag250. eCollection 2026. PMID- 42491691 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260723 LR - 20260813 IS - 2474-0527 (Electronic) IS - 2474-0527 (Linking) VI - 10 IP - 1 DP - 2026 TI - Pain Rehabilitation Virtual Reality (PR-VR) at Home: A Pilot Randomized Controlled Trial for Youth with Chronic Pain. PG - 2683648 LID - 10.1080/24740527.2026.2683648 [doi] LID - 2683648 AB - BACKGROUND: Pain Rehabilitation Virtual Reality (PR-VR) is a novel tool designed to engage youth with chronic pain in exercise as a part of physiotherapy. PR-VR has been evaluated in day-treatment and outpatient settings, but not for at home use. AIMS: To evaluate the feasibility, acceptability and safety of PR-VR at home for youth with chronic pain. An exploratory aim evaluated the preliminary effectiveness of PR-VR on pain and disability. METHODS: This was a 3-arm pilot randomized controlled trial (registration #NCT04912817). Each study arm included four 60-min physiotherapy sessions via Zoom (1: commercially available VR; 2: custom-developed PR-VR; 3: standard physiotherapy care). Feasibility metrics included enrollment, accrual, and drop-out rates. Acceptability was measured via satisfaction surveys and qualitative interviews. Pain and disability were measured via self-report, physical performance, and actigraphy. RESULTS: Thirty-seven of 70 eligible patients approached were enrolled and randomized (53% enrollment rate, 100% accrual rate), including 28 females (76%) aged 10-17 years. Twenty-eight participants completed the study (33% drop-out rate; reasons include pain resolution, medical complexity, dissatisfaction with assignment to control). Ten minor adverse events were reported across study arms. Participants and physiotherapists expressed high levels of VR acceptability. Of the participants who completed arms 1 and 2 (n = 17), 94% were satisfied/very satisfied with VR and 100% rated VR as easy/very easy to use. CONCLUSIONS: Results from this study demonstrate the safety and acceptability of VR in pediatric pain rehabilitation. These feasibility results will inform the design of future large-scale trials, including consideration of a wait-list control group. TRIAL REGISTRATION: ClinicalTrials.gov, NCT04912817. CI - (c) 2026 The Author(s). Published with license by Taylor & Francis Group, LLC. FAU - Mesaroli, Giulia AU - Mesaroli G AD - Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada. AD - Department of Rehabilitation Services, The Hospital for Sick Children, Toronto, Canada. AD - Department of Physical Therapy, University of Toronto, Toronto, Canada. FAU - Xi, Richard AU - Xi R AD - Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada. FAU - Hroch Tiessen, Petra AU - Hroch Tiessen P AD - Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, Canada. FAU - Kurup, Uttara AU - Kurup U AD - Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada. FAU - Nishat, Fareha AU - Nishat F AD - Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada. FAU - Killackey, Tieghan AU - Killackey T AD - Peter Munk Cardiac Centre, University Health Network, Toronto, Canada. AD - Lawrence Bloomberg Faculty of Nursing, University of Toronto, Toronto, Canada. FAU - Sucha, Ewa AU - Sucha E AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, Canada. FAU - Simons, Laura E AU - Simons LE AD - Department of Anesthesiology, Perioperative & Pain Medicine, Stanford University School of Medicine, Palo Alto, USA. FAU - Stephens, Samantha AU - Stephens S AD - Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada. FAU - Campbell, Fiona AU - Campbell F AD - Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, Canada. AD - Temerty Faculty of Medicine, University of Toronto, Toronto, Canada. FAU - Stinson, Jennifer AU - Stinson J AUID- ORCID: 0000-0002-9969-8052 AD - Child Health Evaluative Sciences, Research Institute, The Hospital for Sick Children, Toronto, Canada. AD - Department of Anesthesia and Pain Medicine, The Hospital for Sick Children, Toronto, Canada. AD - Lawrence Bloomberg Faculty of Nursing, University of Toronto, Toronto, Canada. LA - eng SI - ClinicalTrials.gov/NCT04912817 PT - Journal Article DEP - 20260716 PL - United States TA - Can J Pain JT - Canadian journal of pain = Revue canadienne de la douleur JID - 101720589 PMC - PMC13378713 OTO - NOTNLM OT - Virtual reality OT - chronic pain OT - pediatric OT - physiotherapy OT - rehabilitation COIS- No potential conflict of interest was reported by the author(s). EDAT- 2026/07/23 18:35 MHDA- 2026/07/23 18:36 PMCR- 2026/07/16 CRDT- 2026/07/23 16:12 PHST- 2026/07/23 18:36 [medline] PHST- 2026/07/23 18:35 [pubmed] PHST- 2026/07/23 16:12 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - 2683648 [pii] AID - 10.1080/24740527.2026.2683648 [doi] PST - epublish SO - Can J Pain. 2026 Jul 16;10(1):2683648. doi: 10.1080/24740527.2026.2683648. eCollection 2026. PMID- 42491065 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260723 LR - 20260813 IS - 1943-8141 (Print) IS - 1943-8141 (Electronic) IS - 1943-8141 (Linking) VI - 18 IP - 6 DP - 2026 TI - Vitamin D +Docosahexaenoic acid supplementation: effects on serum markers and symptoms in ADHD children. PG - 4753-4764 LID - 10.62347/VDPV7251 [doi] AB - OBJECTIVE: To investigate the effect of vitamin D combined with Docosahexaenoic acid (DHA) supplementation on serum indicators, clinical symptoms and disease severity in children with attention deficit hyperactivity disorder (ADHD), and identify independent risk factors for treatment efficacy. METHODS: A retrospective analysis was performed on 367 children with ADHD admitted from August 2020 to August 2024, divided into control group (routine behavioral education + atomoxetine hydrochloride, n=180) and nutritional intervention (NI) group (additional vitamin D + DHA, n=187). The sample was split into training set (n=256) and validation set (n=111) at a 7:3 ratio, with relevant indicators analyzed via logistic regression, nomogram and ROC curve. RESULTS: After 3 months of treatment, the NI group had significantly lower ADHD Rating Scale IV (ADHD-RS-IV) and Clinical Global Impression Scale-Severity (CGI-S) scores, higher serum 25-hydroxyvitamin D [25(OH)D] and ferritin (SF) levels, higher total effective rate (94.49% vs 82.95%, P=0.004), and lower adverse reaction rate (4.72% vs 13.18%, P=0.018) than the control group (all P<0.05). Baseline ADHD-RS-IV>/=26.5 points, CGI-S>/=4.5 points, 25(OH)D<14.26 ng/mL and SF<19.61 ng/mL were independent risk factors for poor efficacy; their combined detection had an Area Under the Curve (AUC) of 0.901 in the validation set. CONCLUSION: Vitamin D combined with DHA can improve clinical symptoms, serum nutritional indicators, efficacy and safety of ADHD children. The 4 indicators are key factors affecting efficacy, and their combined detection has more accurate diagnostic efficiency. CI - AJTR Copyright (c) 2026. FAU - Cai, Jianying AU - Cai J AD - Department of Child Healthcare, Baoji Maternal and Child Health Hospital East Section of Jing'er Road, Weibin District, Baoji 721000, Shaanxi, China. FAU - Liu, Yuan AU - Liu Y AD - Department of Pediatric Infectious Diseases, Baoji Maternal and Child Health Hospital East Section of Jing'er Road, Weibin District, Baoji 721000, Shaanxi, China. LA - eng PT - Journal Article DEP - 20260615 PL - United States TA - Am J Transl Res JT - American journal of translational research JID - 101493030 PMC - PMC13375999 OTO - NOTNLM OT - 25-hydroxyvitamin D OT - Vitamin D OT - attention deficit hyperactivity disorder OT - docosahexaenoic acid OT - serum ferritin COIS- None. EDAT- 2026/07/23 18:35 MHDA- 2026/07/23 18:36 PMCR- 2026/06/15 CRDT- 2026/07/23 15:55 PHST- 2026/01/22 00:00 [received] PHST- 2026/04/24 00:00 [accepted] PHST- 2026/07/23 18:36 [medline] PHST- 2026/07/23 18:35 [pubmed] PHST- 2026/07/23 15:55 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.62347/VDPV7251 [doi] PST - epublish SO - Am J Transl Res. 2026 Jun 15;18(6):4753-4764. doi: 10.62347/VDPV7251. eCollection 2026. PMID- 42490625 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260813 IS - 1549-1676 (Electronic) IS - 1549-1277 (Print) IS - 1549-1277 (Linking) VI - 23 IP - 7 DP - 2026 Jul TI - Exploring parental prenatal influences on child health: A multicohort study and data visualisation tool. PG - e1005153 LID - 10.1371/journal.pmed.1005153 [doi] LID - e1005153 AB - BACKGROUND: The Developmental Origins of Health and Disease (DOHaD) hypothesis suggests that early life environmental exposures, especially during pregnancy, can impact long-term health. Research has largely relied on correlational evidence and has focussed on maternal factors, with less attention given to paternal, postnatal, and broader social determinants. This focus could complicate efforts to determine the most effective strategies for improving population health. METHODS AND FINDINGS: Using harmonised data across four population-based longitudinal cohort studies from the UK and Norway (births between 1991 and 2008), we took a systematic approach to explore associations of parental prenatal health behaviours (smoking, alcohol, and caffeine consumption) and low socioeconomic position (SEP) with 72 child health-related outcomes (e.g., related to body size and composition, cognitive function, mental health, blood pressure, allergy, etc.) from birth up to age 11. Where possible, cohort estimates were meta-analysed, yielding a maximum sample size of 232,139. We triangulated evidence of causality using different analytical approaches, including a Mendelian randomisation-informed approach using genetic risk scores, negative controls (maternal versus paternal and during versus post-pregnancy comparisons), and dose-response analyses. This comprehensive set of analyses generated more than 594,000 effect estimates. We developed a web app, 'EPoCH Explorer' to visualise and share our results in an accessible format. We did not find strong evidence for widespread or large effects of parental health behaviours on child health and wellbeing. Only 6% of analyses had a Cohen's D value >0.2 and FDR-adjusted P < 0.05. In most analyses, the effect estimate was similar for mothers and partners, with 51% showing a larger effect for mothers and 49% for partners. Despite the lack of widespread associations, we found consistent evidence of association between maternal smoking and small for gestational age, higher childhood body mass index (BMI), depressive symptoms, and behavioural issues, while partner smoking was consistently associated with childhood BMI and social communication difficulties. Overall, we found stronger evidence of child outcomes being associated with low SEP than with health behaviours: 15% of results for low SEP had a Cohen's D value >0.2 and FDR-P < 0.05, compared to 6% for parental smoking, 3% for alcohol, and 0.4% for caffeine. Sample sizes and statistical power varied across outcomes and there was limited ethnic diversity in our study samples. CONCLUSION: Our findings suggest that wider familial socioeconomic conditions may be a more important determinant of child health than specific parental health behaviours prenatally. Interventions to improve population health may be most effective if they target wider social inequalities, rather than individual behaviours and mothers specifically. We encourage researchers to use EPoCH Explorer to prioritise associations for exploration in their own datasets, thus enabling replication and cross-context comparison to validate and extend the generalisability of our findings. CI - Copyright: (c) 2026 Sharp et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Sharp, Gemma C AU - Sharp GC AUID- ORCID: 0000-0003-2906-4035 AD - School of Psychology, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom. AD - MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom. FAU - Lawlor, Deborah A AU - Lawlor DA AUID- ORCID: 0000-0002-6793-2262 AD - MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom. AD - Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom. FAU - Easey, Kayleigh E AU - Easey KE AD - MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom. AD - School of Psychological Science, University of Bristol, Bristol, United Kingdom. FAU - Kundu, Sampurna AU - Kundu S AD - School of Psychology, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom. FAU - Elhakeem, Ahmed AU - Elhakeem A AD - School of Psychology, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom. AD - MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom. AD - Population Health Science, Bristol Medical School, University of Bristol, Bristol, United Kingdom. FAU - Hone, Edward AU - Hone E AD - Research Software Engineers Group, University of Exeter, Exeter, United Kingdom. FAU - McEachan, Rosemary R C AU - McEachan RRC AUID- ORCID: 0000-0003-1302-6675 AD - Bradford Institute for Health Research, Bradford Teaching Hospitals National Health Service Foundation Trust, Bradford, United Kingdom. FAU - Magnus, Maria C AU - Magnus MC AUID- ORCID: 0000-0002-0568-3774 AD - Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway. FAU - Havdahl, Alexandra AU - Havdahl A AD - Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway. AD - PsychGen Centre for Genetic Epidemiology and Mental Health, Division of Public Health and Prevention, Norwegian Institute of Public Health, Oslo, Norway. AD - Center for Genetic Epidemiology and Mental Health, Norwegian Institute of Public Health, Oslo, Norway. AD - PROMENTA Research Centre, Department of Psychology, University of Oslo, Oslo, Norway. FAU - Relton, Caroline L AU - Relton CL AD - MRC Integrative Epidemiology Unit at the University of Bristol, Bristol, United Kingdom. AD - London School of Hygiene and Tropical Medicine, London, United Kingdom. LA - eng PT - Journal Article DEP - 20260723 PL - United States TA - PLoS Med JT - PLoS medicine JID - 101231360 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Child Health MH - Child MH - *Prenatal Exposure Delayed Effects/epidemiology MH - Norway/epidemiology MH - Male MH - United Kingdom/epidemiology MH - Longitudinal Studies MH - Child, Preschool MH - Developmental Origins of Health and Disease MH - Smoking/adverse effects/epidemiology MH - Infant MH - Health Behavior MH - Infant, Newborn MH - *Parents MH - Alcohol Drinking/adverse effects/epidemiology MH - Risk Factors PMC - PMC13395330 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/23 18:35 MHDA- 2026/07/23 18:36 PMCR- 2026/07/23 CRDT- 2026/07/23 15:13 PHST- 2025/08/12 00:00 [received] PHST- 2026/06/05 00:00 [accepted] PHST- 2026/07/23 18:36 [medline] PHST- 2026/07/23 18:35 [pubmed] PHST- 2026/07/23 15:13 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - PMEDICINE-D-25-02845 [pii] AID - 10.1371/journal.pmed.1005153 [doi] PST - epublish SO - PLoS Med. 2026 Jul 23;23(7):e1005153. doi: 10.1371/journal.pmed.1005153. eCollection 2026 Jul. PMID- 42490250 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20261008 IS - 1939-134X (Electronic) IS - 1040-3590 (Linking) VI - 38 IP - 10 DP - 2026 Oct TI - Psychometric validation of the Italian State Urge to Be Physically Active Questionnaire in eating disorders: Psychopathology correlates and diagnostic differences. PG - e39-e50 LID - 10.1037/pas0001495 [doi] AB - Alongside excessive physical activity, individuals with eating disorders (EDs) frequently report a heightened urge to move and physical restlessness, which may contribute to both somatic and psychological burden. The State Urge to be Physically Active Questionnaire (SUPA-Q) specifically measures this acute, state-like dimension in ED patients, but a validated Italian version is not yet available. Two hundred thirty-three inpatients (93.6% female; M(age) = 31.7 +/- 14.3) formally diagnosed with EDs completed the SUPAQ-I alongside measures of compulsive exercise, exercise addiction, impulsivity, and ED psychopathology. Psychometric evaluation covered item performance, internal consistency, confirmatory factor analysis, convergent/divergent validity, sensitivity to change, and exploratory clinical cutoffs. Paired-samples t tests assessed score changes. SUPAQ-I scores demonstrated excellent reliability (alpha = .958, omega = 0.959) and good factorial validity. Scores significantly positively correlated with ED severity (drive for thinness, body dissatisfaction, overcontrol) and negatively with body mass index. Post hoc analyses revealed higher scores occurring in anorexia nervosa compared to binge-eating disorder, which decreased significantly over hospitalization, findings that are consistent with sensitivity to clinical change. High scores predominated in restrictive anorexia nervosa subtypes. Overall, findings support the psychometric adequacy of SUPAQ-I score interpretations for measuring acute movement urges in EDs. It appeared to capture an affect-driven and state-related dimension of movement urges related to, but not fully explained by, existing trait-based exercise measures and showed sensitive to clinical change. Further research is needed to refine cutoffs and examine the generalizability of these findings across populations and settings. (PsycInfo Database Record (c) 2026 APA, all rights reserved). FAU - Boltri, Margherita AU - Boltri M AUID- ORCID: 0000-0002-6742-8541 AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research. FAU - Gabutti, Carolina AU - Gabutti C AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research. FAU - Brusa, Federico AU - Brusa F AUID- ORCID: 0000-0002-5353-7296 AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research. FAU - Cera, Giulia AU - Cera G AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research. FAU - Villa, Valentina AU - Villa V AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Laboratorio di Psicologia, Ospedale San Giuseppe. FAU - Bastoni, Ilaria AU - Bastoni I AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Laboratorio di Psicologia, Ospedale San Giuseppe. FAU - Ducale, Sara AU - Ducale S AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Laboratorio di Psicologia, Ospedale San Giuseppe. FAU - Manzo, Francesca AU - Manzo F AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Unita Operativa Complessa dei Disturbi dell'Alimentazione e della Nutrizione, Ospedale San Giuseppe. FAU - Scalia, Alberto AU - Scalia A AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Unita Operativa Complessa dei Disturbi dell'Alimentazione e della Nutrizione, Ospedale San Giuseppe. FAU - Apicella, Emanuela AU - Apicella E AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research. FAU - Savino, Sandra AU - Savino S AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Unita Operativa Complessa dei Disturbi dell'Alimentazione e della Nutrizione, Ospedale San Giuseppe. FAU - Castelnuovo, Gianluca AU - Castelnuovo G AD - Department of Psychology, Universita Cattolica del Sacro Cuore. FAU - Mendolicchio, Leonardo AU - Mendolicchio L AD - Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Auxologico Italiano, Experimental Laboratory for Metabolic Neurosciences Research. LA - eng SI - ClinicalTrials.gov/NCT06514456 GR - Italian Ministry of Health/ PT - Journal Article PT - Validation Study DEP - 20260723 PL - United States TA - Psychol Assess JT - Psychological assessment JID - 8915253 SB - IM MH - Humans MH - Female MH - Psychometrics MH - Adult MH - Reproducibility of Results MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Italy MH - Surveys and Questionnaires/standards MH - Male MH - Young Adult MH - *Anorexia Nervosa/diagnosis/psychology MH - Adolescent MH - Middle Aged MH - *Exercise/psychology MH - Compulsive Exercise/psychology MH - Impulsive Behavior EDAT- 2026/07/23 18:35 MHDA- 2026/09/21 17:47 CRDT- 2026/07/23 12:43 PHST- 2026/09/21 17:47 [medline] PHST- 2026/07/23 18:35 [pubmed] PHST- 2026/07/23 12:43 [entrez] AID - 2028-02437-001 [pii] AID - 10.1037/pas0001495 [doi] PST - ppublish SO - Psychol Assess. 2026 Oct;38(10):e39-e50. doi: 10.1037/pas0001495. Epub 2026 Jul 23. PMID- 42489856 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260813 IS - 1867-0687 (Electronic) IS - 1708-8569 (Print) VI - 22 IP - 6 DP - 2026 Jun TI - BMI-for-age Z-score trajectories in early childhood: a comparison of GMM and KML and associated antenatal and postnatal factors. PG - 664-677 LID - 10.1007/s12519-026-01057-y [doi] AB - BACKGROUND: Early-life growth trajectories, especially during the first two years, are important for future health. However, in the context of rapidly rising childhood obesity, it is essential to characterize BMI-for-age Z-score (BAZ) trajectories in early childhood, compare optimal modeling approaches, and identify associated risk factors. METHODS: This prospective birth cohort study enrolled participants in Jinan, Shandong from 2019 to 2022. World Health Organization (WHO)-standardized BAZ scores were calculated for children at eight timepoints (0-24 months). Sex-specific BAZ trajectories were derived using growth mixture modeling (GMM) and k-means for longitudinal data (KML). The possible risk of being overweight (BAZ > 1) at age three years was predicted using logistic regression with five folds cross-validation, comparing model performance via the area under the curve (AUC). Associations between trajectory classification and antenatal and postnatal factors were examined. RESULTS: A total of 4629 mother-infant dyads were enrolled in this study. The KML-derived four-class trajectory model demonstrated optimal predictive performance for possible risk of being overweight at age three years, achieving an AUC of 0.749 and significantly outperforming the GMM model (AUC = 0.571). Male sex [odds ratio (OR) = 1.314; 95% confidence interval (95% CI): 1.098, 1.572], high birth weight (OR = 4.739; 95% CI: 3.594, 6.250), multiparity (OR = 1.265; 95% CI: 1.003, 1.594), and gestational hypertension (OR = 2.581; 95% CI: 1.387, 4.801) were identified as risk factors for high growth trajectory. CONCLUSIONS: The KML model was identified as the more effective approach for delineating BAZ trajectories and predicting the risk of being overweight in our study population. Furthermore, male sex, high birth weight, multiparity, and gestational hypertension were identified as key antenatal and postnatal factors associated with higher growth trajectories. CI - (c) 2026. The Author(s). FAU - Zhang, Ting AU - Zhang T AD - Clinical Research Center for Children's Health and Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. FAU - Li, Zi-Yun AU - Li ZY AD - Clinical Research Center for Children's Health and Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. FAU - Zhang, Zhen-Yu AU - Zhang ZY AD - School of Clinical Medicine, Shandong Second Medical University, Weifang, China. FAU - Gao, Mai AU - Gao M AD - Clinical Research Center for Children's Health and Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. FAU - Zhang, Li AU - Zhang L AD - Clinical Research Center for Children's Health and Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. FAU - Liu, Hui-Juan AU - Liu HJ AD - Clinical Research Center for Children's Health and Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. FAU - Wang, Hai-Jun AU - Wang HJ AD - Department of Maternal and Child Health, School of Public Health, National Health Commission Key Laboratory of Reproductive Health, Peking University, Beijing, China. FAU - Li, Yan AU - Li Y AUID- ORCID: 0000-0003-2233-7061 AD - Clinical Research Center for Children's Health and Diseases, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. liyanxj@sina.com. LA - eng GR - 32500156/National Natural Science Foundation of China/ GR - Z20243204/Shandong Province Traditional Chinese Medicine Science and Technology Project/ PT - Comparative Study PT - Journal Article DEP - 20260723 PL - Switzerland TA - World J Pediatr JT - World journal of pediatrics : WJP JID - 101278599 SB - IM MH - Humans MH - Male MH - Female MH - Prospective Studies MH - *Body Mass Index MH - Child, Preschool MH - Risk Factors MH - Infant MH - Birth Cohort MH - *Pediatric Obesity/epidemiology MH - Infant, Newborn MH - China/epidemiology PMC - PMC13433460 OTO - NOTNLM OT - BAZ trajectory OT - Children OT - Growth mixture modeling OT - K-means for longitudinal data OT - Pediatric OT - Possible risk of being overweight COIS- Declarations. Conflict of interest: No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. Ethical approval: Ethical approval was granted by Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University (No. 2025-040). EDAT- 2026/07/23 12:37 MHDA- 2026/08/04 06:37 PMCR- 2026/07/23 CRDT- 2026/07/23 11:08 PHST- 2026/01/06 00:00 [received] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/02/24 00:00 [revised] PHST- 2026/08/04 06:37 [medline] PHST- 2026/07/23 12:37 [pubmed] PHST- 2026/07/23 11:08 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - 10.1007/s12519-026-01057-y [pii] AID - 1057 [pii] AID - 10.1007/s12519-026-01057-y [doi] PST - ppublish SO - World J Pediatr. 2026 Jun;22(6):664-677. doi: 10.1007/s12519-026-01057-y. Epub 2026 Jul 23. PMID- 42489731 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260923 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 8 DP - 2026 Jul 23 TI - Psychological and lifestyle predictors of paediatric sleep disturbances: a cross-sectional study. LID - 10.1007/s00431-026-07254-1 [doi] LID - 603 AB - Sleep disturbances are frequent in childhood and have been associated with emotional vulnerability and modifiable lifestyle behaviours. The relative and combined contributions of child anxiety, parental anxiety, and unstructured daily routines to paediatric sleep disturbances remain incompletely characterized. We conducted a cross-sectional study of 306 otherwise healthy children aged 3-14 years. Parents completed validated questionnaires assessing sleep disturbances, child anxiety, parental anxiety, and daily lifestyle habits, including evening screen exposure. Multivariable linear regression, mediation, and cluster analyses were performed to identify correlates of sleep disturbances and distinct profiles. Clinically significant sleep disturbances were identified in 39.2% of participants. Higher child trait anxiety was consistently associated with greater sleep disturbance severity (all P < .001). Evening screen exposure was independently associated with higher sleep disturbance scores (P < .05). Parental trait anxiety not directly associated with sleep disturbances both directly and indirectly through child trait anxiety, which mediated approximately 30% of the association (P < .001). Cluster analysis identified three distinct profiles, including two groups with comparable sleep disturbance severity but contrasting characteristics: one marked by high emotional vulnerability and one by predominant lifestyle dysregulation. Conclusion: Sleep disturbances are strongly associated with trait anxiety and independently related to evening screen exposure, while parental anxiety appears to exert its effect both directly and, in part, indirectly through child anxiety. Similar sleep complaints may reflect different underlying emotional and lifestyle mechanisms. A multidimensional assessment integrating anxiety screening and evaluation of evening habits may improve early identification of at-risk children and support targeted preventive strategies within routine paediatric care. CI - (c) 2026. The Author(s). FAU - Suppiej, Agnese AU - Suppiej A AUID- ORCID: 0000-0001-5130-1450 AD - Paediatric Unit, University Hospital S. Anna, University of Ferrara, Ferrara, Italy. FAU - Sigolotto, Elia AU - Sigolotto E AUID- ORCID: 0009-0002-0673-856X AD - Paediatric Unit, University Hospital S. Anna, University of Ferrara, Ferrara, Italy. elia.sigolotto@edu.unife.it. FAU - Malaventura, Cristina AU - Malaventura C AUID- ORCID: 0000-0001-8517-4170 AD - Paediatric Unit, University Hospital S. Anna, University of Ferrara, Ferrara, Italy. LA - eng PT - Journal Article DEP - 20260723 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Child MH - Female MH - *Sleep Wake Disorders/psychology/etiology/epidemiology MH - Male MH - Child, Preschool MH - *Life Style MH - Adolescent MH - *Anxiety/complications/psychology MH - Surveys and Questionnaires MH - *Parents/psychology MH - Risk Factors MH - Screen Time PMC - PMC13395844 OTO - NOTNLM OT - Child anxiety OT - Parental anxiety OT - Screen exposure OT - Sleep disturbances OT - Sleep hygiene COIS- Declarations. Ethics approval: This study adhered to the principles of the Declaration of Helsinki. Because it involved a completely anonymous, online form without collection of identifying information, approval by an Institutional Ethics Committee was not required. Consent to participate: Parents or legal guardians provided verbal consent to receive the form, and subsequent participation was entirely voluntary. No personal data were collected. Consent to publish: Not applicable. Use of AI-assisted technologies: During the preparation of this work, the authors used ChatGPT (OpenAI) solely to improve language, readability, and grammatical accuracy. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication. Role of the funder: The funder had no role in the study design; data collection, analysis, or interpretation; manuscript preparation; or decision to submit the manuscript for publication. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/07/23 12:37 MHDA- 2026/07/23 12:38 PMCR- 2026/07/23 CRDT- 2026/07/23 11:04 PHST- 2026/02/07 00:00 [received] PHST- 2026/07/12 00:00 [accepted] PHST- 2026/05/04 00:00 [revised] PHST- 2026/07/23 12:38 [medline] PHST- 2026/07/23 12:37 [pubmed] PHST- 2026/07/23 11:04 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - 10.1007/s00431-026-07254-1 [pii] AID - 7254 [pii] AID - 10.1007/s00431-026-07254-1 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jul 23;185(8):603. doi: 10.1007/s00431-026-07254-1. PMID- 42489125 OWN - NLM STAT- Publisher LR - 20260723 IS - 1934-1563 (Electronic) IS - 1934-1482 (Linking) DP - 2026 Jul 23 TI - Lifestyle medicine innovations: Physical activity assessment in patient care and implementation of a digital health platform to support healthier movement. LID - 10.1002/pmrj.70185 [doi] AB - OBJECTIVE: To introduce the ExerciseRxTM digital health platform as a scalable approach to support personalized physical activity (PA) and home exercise as part of clinical care. DESIGN: Narrative review of Physical Activity Vital Sign (PAVS) integration within an academic healthcare system as well as description and ongoing research on a digital health platform to support physical activity as part of patient care. SETTING: Outpatient clinics within an academic medical center. PARTICIPANTS: Patients across multiple populations, including individuals with limb loss, multiple sclerosis, and primary care cohorts, as well as participants in pediatric rehabilitation, oncology, and rheumatology clinics. INTERVENTIONS: Integration of two standardized PAVS questions into the electronic health record and development of the ExerciseRx digital health platform incorporating smartphone and wearable step count tracking, personalized activity goals, and AI/ML home exercise sensing innovations. MAIN OUTCOME MEASURES: Self-reported PA levels, associations with demographic and clinical factors, healthcare utilization, and feasibility and usability of the digital health platform. RESULTS: PAVS assessment implementation demonstrated that a majority of patients across multiple clinic populations did not meet PA recommendations and highlighted demographic and clinical differences in activity levels. Higher self-reported PA was associated with lower healthcare utilization while controlling for confounding factors. Preliminary findings involving the ExerciseRx platform showed feasibility, high usability, and increased PA engagement, while enabling providers to monitor patient progress with actionable data. CONCLUSIONS: Routine assessment of PA through PAVS, combined with digital health tools such as the ExerciseRx platform, may help identify insufficiently active patients and support personalized, home-based exercise at scale. This approach aligns with priorities in lifestyle medicine and population health, with further research needed on clinical integration at scale. CI - (c) 2026 The Author(s). PM&R published by Wiley Periodicals LLC on behalf of American Academy of Physical Medicine and Rehabilitation. FAU - Lin, Cindy Y AU - Lin CY AD - Department of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA. AD - The Sports Institute at UW Medicine, Seattle, Washington, USA. FAU - Kehne, Theresa AU - Kehne T AUID- ORCID: 0009-0008-6453-2790 AD - Department of Rehabilitation Medicine, University of Washington, Seattle, Washington, USA. AD - The Sports Institute at UW Medicine, Seattle, Washington, USA. LA - eng GR - Seattle Children's Research Institute/ GR - Bladder Cancer Advocacy Network/ GR - NCT06270641/National Multiple Sclerosis Society/ GR - Spondylitis Association of America/ GR - The Sports Institute at UW Medicine/ PT - Journal Article DEP - 20260723 PL - United States TA - PM R JT - PM & R : the journal of injury, function, and rehabilitation JID - 101491319 SB - IM EDAT- 2026/07/23 12:37 MHDA- 2026/07/23 12:37 CRDT- 2026/07/23 06:24 PHST- 2026/04/18 00:00 [revised] PHST- 2025/12/02 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/07/23 12:37 [medline] PHST- 2026/07/23 12:37 [pubmed] PHST- 2026/07/23 06:24 [entrez] AID - 10.1002/pmrj.70185 [doi] PST - aheadofprint SO - PM R. 2026 Jul 23. doi: 10.1002/pmrj.70185. PMID- 42488399 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260723 LR - 20260822 IS - 2673-3153 (Electronic) IS - 2673-3153 (Print) IS - 2673-3153 (Linking) VI - 8 DP - 2026 TI - Understanding practices of lactation and infant feeding together with women with HIV: the UPLIFT observational study protocol. PG - 1856899 LID - 10.3389/frph.2026.1856899 [doi] LID - 1856899 AB - INTRODUCTION: There is a limited understanding of infant feeding decisions, practices, and outcomes for women living with HIV (WLHIV) and their infants since U.S. guidelines were updated in 2023 to support breastfeeding for virally suppressed women on antiretroviral treatment. METHODS AND ANALYSIS: The Understanding Practices of Lactation and Infant Feeding Together with women with HIV (UPLIFT) study is a convergent mixed-methods, multisite, observational study designed to address key knowledge gaps. Twelve US sites will begin enrollment in early 2026 to accomplish three core activities (CA). In CA1, we explore infant feeding decision-making and experiences via in-depth interviews with pregnant/postpartum WLHIV (n = 50), their partners and other influential individuals (n = 25), and a diverse sample of healthcare professionals (n = 45). Site-level surveys assess infant feeding practices and estimate the prevalence of breastfeeding among WLHIV. In CA2, we establish an observational longitudinal cohort of 450 WLHIV-infant dyads to examine infant feeding practices and outcomes. WLHIV will be enrolled during pregnancy and early postpartum, with half intending to breastfeed, and will be followed for >/=48 weeks. Clinical and laboratory data will be collected. Comprehensive surveys collect data on demographics, social determinants of health, mental health, antiretroviral therapy adherence, and infant feeding intentions and experiences. We measure HIV RNA and DNA in breast milk to determine factors associated with detectable HIV. Finally, we estimate the costs and benefits associated with breastfeeding compared to replacement feeding. In CA3, we develop and pilot a voluntary registry of U.S. WLHIV who are breastfeeding and their infants (n = 50-200). Pilot registry testers (n = 30) will provide feedback on the usability, acceptability, appropriateness, and feasibility of the registry. DISCUSSION: The UPLIFT study will generate critical insights to inform patient-centered care, guide practice and policy, and empower WLHIV in the US to make informed infant feeding decisions. ETHICS AND DISSEMINATION: The UPLIFT study received approval from Advarra, the institutional review board of record for all UPLIFT sites. Results will be disseminated through conference presentations, peer-reviewed journals, and lay summaries. CLINICAL TRIAL REGISTRATION: https://clinicaltrials.gov/study/NCT07293559, NCT07293559. CI - (c) 2026 Smith, Barr, Hampanda, Trumbull, Wu, McKinney, Buisson, Hoffmann, Brown, Hutchinson, Amico, Asiodu, McFarland, Lampe, Cholli, Varechtchouk, Esber, Kourtis and Abuogi. FAU - Smith, Christiana AU - Smith C AD - Department of Pediatrics, Section of Infectious Diseases and Epidemiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States. FAU - Barr, Emily Anne AU - Barr EA AD - School of Nursing, University at Buffalo, Buffalo, NY, United States. FAU - Hampanda, Karen AU - Hampanda K AD - Department of Obstetrics and Gynecology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States. FAU - Trumbull, Mark AU - Trumbull M AD - Frontier Science & Technology Research Foundation, Amherst, NY, United States. FAU - Wu, Hulin AU - Wu H AD - Department of Biostatistics & Data Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, United States. FAU - McKinney, Jennifer AU - McKinney J AD - Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Baylor College of Medicine, Houston, TX, United States. FAU - Buisson, Sarah AU - Buisson S AD - FHI 360, Durham, NC, United States. FAU - Hoffmann, Carly AU - Hoffmann C AD - Frontier Science & Technology Research Foundation, Amherst, NY, United States. FAU - Brown, Ciarra AU - Brown C AD - The Well Project, Brooklyn, NY, United States. FAU - Hutchinson, Angela B AU - Hutchinson AB AD - Division of HIV Prevention, National Center for HIV, Hepatitis, Sexually Transmitted Diseases and Tuberculosis Prevention, Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS), Atlanta, GA, United States. FAU - Amico, K Rivet AU - Amico KR AD - University of Michigan, School of Public Health, Ann Arbor, MI, United States. FAU - Asiodu, Ifeyinwa V AU - Asiodu IV AD - School of Nursing, University of California San Francisco, San Francisco, CA, United States. FAU - McFarland, Elizabeth J AU - McFarland EJ AD - Department of Pediatrics, Section of Infectious Diseases and Epidemiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States. FAU - Lampe, Margaret A AU - Lampe MA AD - Division of HIV Prevention, National Center for HIV, Hepatitis, Sexually Transmitted Diseases and Tuberculosis Prevention, Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS), Atlanta, GA, United States. FAU - Cholli, Preetam A AU - Cholli PA AD - Division of HIV Prevention, National Center for HIV, Hepatitis, Sexually Transmitted Diseases and Tuberculosis Prevention, Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS), Atlanta, GA, United States. FAU - Varechtchouk, Olga AU - Varechtchouk O AD - Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States. FAU - Esber, Allahna AU - Esber A AD - Maternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States. FAU - Kourtis, Athena P AU - Kourtis AP AD - Division of HIV Prevention, National Center for HIV, Hepatitis, Sexually Transmitted Diseases and Tuberculosis Prevention, Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS), Atlanta, GA, United States. FAU - Abuogi, Lisa AU - Abuogi L AD - Department of Pediatrics, Section of Infectious Diseases and Epidemiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States. LA - eng SI - ClinicalTrials.gov/NCT07293559 GR - HHSN275201800001C/HD/NICHD NIH HHS/United States GR - UM1 AI068632/AI/NIAID NIH HHS/United States GR - U01PS005288/ACL/ACL HHS/United States GR - U01 PS005288/PS/NCHHSTP CDC HHS/United States GR - UM1 AI068616/AI/NIAID NIH HHS/United States GR - UM1 AI106716/AI/NIAID NIH HHS/United States GR - HHSN275201800001I/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20260708 PL - Switzerland TA - Front Reprod Health JT - Frontiers in reproductive health JID - 9918230899006676 PMC - PMC13388547 OTO - NOTNLM OT - breast milk OT - breastfeeding OT - infant exposure to HIV OT - infant feeding OT - lactation OT - perinatal HIV transmission OT - pregnancy OT - woman living with HIV COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/23 06:39 MHDA- 2026/07/23 06:40 PMCR- 2026/07/08 CRDT- 2026/07/23 04:51 PHST- 2026/04/15 00:00 [received] PHST- 2026/06/03 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/07/23 06:40 [medline] PHST- 2026/07/23 06:39 [pubmed] PHST- 2026/07/23 04:51 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - 10.3389/frph.2026.1856899 [doi] PST - epublish SO - Front Reprod Health. 2026 Jul 8;8:1856899. doi: 10.3389/frph.2026.1856899. eCollection 2026. PMID- 42487800 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Enhancing organizational health literacy through pediatric clinical training: Mini-CEX-based formative assessment in case-based learning for pediatric pneumonia-a perspective. PG - 1880936 LID - 10.3389/fpubh.2026.1880936 [doi] LID - 1880936 AB - Organizational health literacy (OHL) remains a critical yet underexplored dimension of health equity, particularly at the interface between clinical training and patient care. This article proposes a conceptual reframing of the Mini-Clinical Evaluation Exercise (Mini-CEX) as an OHL-oriented formative assessment tool within case-based learning for pediatric pneumonia. The OHL-Mini-CEX model integrates three assessment domains-teach-back evaluation, de-jargonization capacity, and empowering guidance-to systematically evaluate residents' communicative competence in addressing health literacy barriers. We delineate the mechanisms through which this instrument operates: embedding equity-conflict scenarios into teaching cases, generating bidirectional formative feedback for both clinicians and organizations, and constructing a closed loop from micro-level training to macro-level health equity outcomes. Implementation challenges, including faculty preparedness gaps and psychometric rigor, are examined alongside integrated strategies drawing on public health collaboration. This perspective advances a theoretically grounded and practically actionable pathway for transforming clinical education into an institutional driver of health equity. CI - Copyright (c) 2026 Ge, Li, Mu and Wan. FAU - Ge, Sheng-Nan AU - Ge SN AD - Department of Pediatric, Luohu District Hospital of Traditional Chinese Medicine, Shenzhen, China. FAU - Li, Bing AU - Li B AD - Department of Pediatric, Luohu District Hospital of Traditional Chinese Medicine, Shenzhen, China. FAU - Mu, Bing-Yan AU - Mu BY AD - Department of Pediatric, Luohu District Hospital of Traditional Chinese Medicine, Shenzhen, China. FAU - Wan, Li-Sheng AU - Wan LS AD - Department of Chinese Medicine, Shenzhen Children's Hospital, Shenzhen, China. LA - eng PT - Journal Article DEP - 20260708 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Health Literacy MH - *Pneumonia/therapy MH - *Pediatrics/education MH - *Problem-Based Learning MH - *Educational Measurement/methods MH - Child PMC - PMC13388563 OTO - NOTNLM OT - Mini-clinical evaluation exercise OT - case-based learning OT - clinical training OT - formative assessment OT - health equity OT - organizational health literacy OT - pediatric pneumonia COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/23 06:39 MHDA- 2026/07/23 06:40 PMCR- 2026/07/08 CRDT- 2026/07/23 04:45 PHST- 2026/05/14 00:00 [received] PHST- 2026/06/04 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/23 06:40 [medline] PHST- 2026/07/23 06:39 [pubmed] PHST- 2026/07/23 04:45 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1880936 [doi] PST - epublish SO - Front Public Health. 2026 Jul 8;14:1880936. doi: 10.3389/fpubh.2026.1880936. eCollection 2026. PMID- 42487370 OWN - NLM STAT- Publisher LR - 20260723 IS - 0975-5764 (Electronic) IS - 0975-5764 (Linking) DP - 2026 Jul 23 TI - CTLA-4 Gene Polymorphism in Pediatric Type 1 Diabetes Mellitus: A Case-Control Study. LID - 10.4103/aam.aam_368_26 [doi] AB - OBJECTIVE: To analyze the relationship between CTLA-4 (+49A/G) polymorphism and pediatric type 1 diabetes mellitus (T1DM). MATERIALS AND METHODS: The observational case-control study was done for 18 months in 44 children (1-16 years of age), 22 of whom had T1DM and 22 controls, were included. CTLA-4 (+49A/G) gene polymorphism was analyzed using polymerase chain reaction-restriction fragment length polymorphism and validated by Sanger sequencing. Various clinical, anthropometric, and biochemistry variables were documented. RESULTS: The cases and controls were similar in terms of age, gender distribution, family history of diabetes, and consanguinity. The average hemoglobin A1c values were higher in case groups compared to controls (12.41% +/-3.09% vs. 4.21 +/- 0.5%; P < 0.001). The CTLA4 (+49A/G) gene showed higher frequencies of the G/G genotype in cases compared to controls (54.55% vs. 22.73%; P = 0.030), whereas A/A was found to be higher in controls (P = 0.014). The frequency of the G allele in cases (0.66) was higher than in controls (0.32). The G/G genotype showed higher prevalence in the case group at a younger age, and siblings of offspring showed clustering of the G/G genotype. CONCLUSION: In particular, the G/G genotype of the CTLA-4 + 49A/G polymorphism was found to be significantly associated with T1DM in children and to influence the age of onset. CI - Copyright (c) 2026 Annals of African Medicine. FAU - Aniketh, Thammineni AU - Aniketh T AD - Department of Pediatrics, Shri B. M. Patil Medical College and Hospital and Research Center, BLDE (Deemed to be University), Vijayapura, Karnataka, India. FAU - Gobbur, Raghavendra AU - Gobbur R AD - Department of Pediatrics, Shri B. M. Patil Medical College and Hospital and Research Center, BLDE (Deemed to be University), Vijayapura, Karnataka, India. FAU - Kadakol, Gurushantappa S AU - Kadakol GS AD - Department of Anatomy, Genetics Laboratory, School of Applied Sciences and Technology, BLDE (Deemed to be University), Vijayapura, Karnataka, India. LA - fre LA - eng PT - Journal Article DEP - 20260723 PL - India TA - Ann Afr Med JT - Annals of African medicine JID - 101231417 SB - IM OTO - NOTNLM OT - +49A/G polymorphism OT - Polymorphisme +49A/G OT - Sanger sequencing OT - diabete sucre de type 1 OT - familial risk OT - genetic susceptibility OT - pediatric OT - pediatrique OT - risque familial OT - susceptibilite genetique OT - sequencage de Sanger OT - type 1 diabetes mellitus EDAT- 2026/07/23 06:39 MHDA- 2026/07/23 06:39 CRDT- 2026/07/23 02:02 PHST- 2026/04/03 00:00 [received] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/07/23 06:39 [medline] PHST- 2026/07/23 06:39 [pubmed] PHST- 2026/07/23 02:02 [entrez] AID - 01244624-990000000-01068 [pii] AID - 10.4103/aam.aam_368_26 [doi] PST - aheadofprint SO - Ann Afr Med. 2026 Jul 23. doi: 10.4103/aam.aam_368_26. PMID- 42487232 OWN - NLM STAT- Publisher LR - 20260723 IS - 2168-6602 (Electronic) IS - 0890-1171 (Linking) DP - 2026 Jul 22 TI - Promoting Active Schools in the United States: A Feasibility Study Applying the Interactive Systems Framework. PG - 8901171261471044 LID - 10.1177/08901171261471044 [doi] AB - PurposeThis feasibility study explored the application of the Interactive Systems Framework for Dissemination and Implementation (ISF) to promote physical activity (PA) in elementary schools, leveraging resources from Active Schools.ApproachA convergent parallel mixed-methods design was used to examine implementation efforts and student PA outcomes.SettingData were collected from eight elementary schools across the United States.ParticipantsThe study included eight Active Schools Champions (physical education teachers) and 371 students.MethodsChampions completed the School Wellness Readiness Assessment (SWRA) and the Comprehensive School Physical Activity Program (CSPAP) Policies and Practices Questionnaire. A survey and interview based on the Consolidated Framework for Implementation Research (CFIR) also captured barriers and facilitators. Concurrently, student PA patterns were assessed using the Youth Activity Profile (YAP).ResultsSchools demonstrated moderate readiness (mean SWRA = 3.7) and implemented an average of 64% of CSPAP best practices. Student PA exceeded national recommendations, averaging 70 minutes per day, with most of this activity occurring during the school day. Organizational barriers, such as a lack of administrative support, were identified.ConclusionThe findings document the successful implementation of CSPAP and provide insights into organizational barriers and facilitators. This study highlights the value of accessible, evidence-based resources and needs assessment tools, while also revealing challenges related to time-intensive professional development and disparities in readiness across different school locales. The results will inform future interventions and resources to promote more equitable PA opportunities. FAU - Ha, Taemin AU - Ha T AUID- ORCID: 0000-0003-2830-9029 AD - Department of Family, Nutrition, and Exercise Sciences, City University of New York-Queens College, New York City, NY, USA. FAU - Stoepker, Peter AU - Stoepker P AUID- ORCID: 0000-0002-1925-5690 AD - School of Health Sciences, Kansas State University, Manhattan, KS, USA. RINGGOLD: 5308 FAU - Welk, Gregory AU - Welk G AD - Department of Kinesiology, Iowa State University, Ames, IA, USA. FAU - Dauenhauer, Brian AU - Dauenhauer B AUID- ORCID: 0000-0001-6766-1178 AD - Department of Kinesiology, Nutrition, and Dietetics, University of Northern Colorado, Greeley, CO, USA. RINGGOLD: 3604 LA - eng PT - Journal Article DEP - 20260722 PL - United States TA - Am J Health Promot JT - American journal of health promotion : AJHP JID - 8701680 SB - IM OTO - NOTNLM OT - physical activity OT - public health OT - school health OT - school system OT - whole-of-school EDAT- 2026/07/23 06:39 MHDA- 2026/07/23 06:39 CRDT- 2026/07/23 00:42 PHST- 2026/07/23 06:39 [medline] PHST- 2026/07/23 06:39 [pubmed] PHST- 2026/07/23 00:42 [entrez] AID - 10.1177/08901171261471044 [doi] PST - aheadofprint SO - Am J Health Promot. 2026 Jul 22:8901171261471044. doi: 10.1177/08901171261471044. PMID- 42487004 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261015 IS - 1437-1596 (Electronic) IS - 0937-9827 (Print) IS - 0937-9827 (Linking) VI - 140 IP - 6 DP - 2026 Nov TI - The influence of adjacent anatomical context in tooth staging: observational study of non-cropped vs. cropped radiographs for dental age estimation. PG - 4483-4493 LID - 10.1007/s00414-026-03929-4 [doi] AB - Dental age estimation (DAE) is applicable to forensic/legal and clinical contexts, with the Demirjian staging system being among the most common techniques. However, inter- and intra-observer variability can affect DAE reliability, particularly when evaluating panoramic radiographs influenced by magnification, distortion, and anatomical superimposition. In the staging process, consciously or unconsciously, experts analyze dental development within the available peripheral anatomic features of the tooth and its peripheral region. This study investigated whether isolating teeth as regions of interest (cropped images) influences the reproducibility of Demirjian's stage allocation. An observational cross-sectional study was conducted using 301 panoramic radiographs from subjects aged 7-14 years. Three experienced forensic odontologists independently staged all seven left mandibular teeth (#31-#37) and, when present, also the left mandibular third molar (#38) using the Demirjian's staging system. Each tooth was evaluated twice, two weeks apart, in both full panoramic radiograph and cropped formats. Inter- and intra-observer agreement was assessed using kappa statistics. Intra-observer agreement was above 0.81. Cropped images resulted in only marginal changes, with a slight decrease in stage reproducibility (Delta - 0.017 and - 0.023). Inter-observer agreement was nearly identical between non-cropped (AC2 = 0.985) and cropped images (AC2 = 0.986). A slightly lower proportion of cropped images was assessable by all observers (90.7% vs. 91.7%). Isolating teeth as regions of interest did not meaningfully reduce reproducibility and only small intra-observer decreases were observed and concentrated in the anterior teeth. These findings indicate that, among experienced observers, cropping does not degrade the reliability of Demirjian stage allocation. Future DAE staging systems should consider being more descriptive, including not only tooth-related developmental details, but surrounding information, such as the distance between the analyzed tooth and the occlusal plane and its relationship with adjacent developed teeth. CI - (c) 2026. The Author(s). FAU - Angelakopoulos, Nikolaos AU - Angelakopoulos N AUID- ORCID: 0000-0001-8511-4645 AD - Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Bern, Switzerland. AD - Department of Forensic Dentistry, Faculdade Sao Leopoldo Mandic, Campinas, Brazil. FAU - Boedi, Rizky Merdietio AU - Boedi RM AUID- ORCID: 0000-0002-5045-6773 AD - Department of Dentistry, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia. AD - Department of Forensic Medicine, Sechenov First Moscow State Medical University, Moscow, Russia. FAU - De Luca, Stefano AU - De Luca S AUID- ORCID: 0000-0002-1725-0853 AD - Area of Physical Anthropology, Department of Organisms and Systems Biology, Faculty of Biology, University of Oviedo, Oviedo, Spain. lucastefano@uniovi.es. FAU - Vazquez, Israel Soriano AU - Vazquez IS AUID- ORCID: 0009-0009-2603-5950 AD - Forensic Odontologist, independent researcher, Mexico City, Mexico. FAU - Franco, Ademir AU - Franco A AUID- ORCID: 0000-0002-1417-2781 AD - Department of Forensic Dentistry, Faculdade Sao Leopoldo Mandic, Campinas, Brazil. LA - eng PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20260723 PL - Germany TA - Int J Legal Med JT - International journal of legal medicine JID - 9101456 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Age Determination by Teeth/methods MH - Cross-Sectional Studies MH - Mandible MH - Observer Variation MH - *Radiography, Panoramic MH - Reproducibility of Results MH - *Tooth/diagnostic imaging/growth & development PMC - PMC13658412 OTO - NOTNLM OT - Age estimation OT - Demirjian system OT - Dental age OT - Forensic dentistry OT - Image cropping OT - Inter-observer agreement OT - Regions of interest OT - Reliability COIS- Declarations. Ethical approval: This study received ethical approval from the Health Research Ethics Committee of the Faculty of Medicine, Universitas Diponegoro (Approval No. 212/EC/KEPK/FK-UNDIP/VIII/2025) The study used fully anonymized, retrospectively collected data from an existing dataset with no direct involvement of human participants. Compliance with ethical standards: The study was carried out following the ethical standards of the Declaration of Helsinki (Finland). Research involving human participants and/or animals: Not applicable. Informed consent: Not applicable. Clinical trial number: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/23 05:36 MHDA- 2026/10/12 17:30 PMCR- 2026/07/23 CRDT- 2026/07/22 23:27 PHST- 2026/06/03 00:00 [received] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/10/12 17:30 [medline] PHST- 2026/07/23 05:36 [pubmed] PHST- 2026/07/22 23:27 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - 10.1007/s00414-026-03929-4 [pii] AID - 3929 [pii] AID - 10.1007/s00414-026-03929-4 [doi] PST - ppublish SO - Int J Legal Med. 2026 Nov;140(6):4483-4493. doi: 10.1007/s00414-026-03929-4. Epub 2026 Jul 23. PMID- 42486265 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260908 IS - 1532-0480 (Electronic) IS - 1532-0464 (Linking) VI - 181 DP - 2026 Sep TI - Predicting healthy weight status from physical activity and dietary intake: A time-aware data mining pipeline. PG - 105083 LID - S1532-0464(26)00107-3 [pii] LID - 10.1016/j.jbi.2026.105083 [doi] AB - OBJECTIVE: To develop and evaluate a time-aware data mining pipeline that integrates accelerometry-based Physical Activity (PA), static dietary intake, and sociodemographic factors to predict Healthy Weight Status (HWS), and identify features with predictive importance for HWS. METHODS: We propose TimePAD, Time-Based Physical Activity and Dietary Intake data mining, a three-stage prediction pipeline that integrates time-based PA representations, static dietary intake, and sociodemographic variables to predict HWS categories. Stage 1 derives intensity-specific hourly PA sequences and learns time-of-day PA embeddings using a Transformer encoder trained with masked Self-Supervised Learning (SSL) reconstruction. Stage 2 combines the learnt PA embeddings with static dietary variables and participant characteristics derived from the Food Frequency Questionnaire (FFQ). Stage 3 trains prediction models and ranks predictors by their predictive importance for HWS. TimePAD was evaluated on a real-world dataset of 206 adolescents (10-16 years) with 7-day continuous wrist-worn accelerometer data, FFQ records, and sociodemographic attributes, using 10-fold cross-validation and comparison to an ARIMA-based feature engineering baseline. RESULTS: TimePAD achieves an accuracy of 82.90% and an F1-score of 67.92% for HWS prediction, outperforming the best baseline (ARIMA-based PA features + diet, 77.51% accuracy). Across experiments, time-of-day light PA (LPA) features were consistently ranked as important predictors. Other key features include time-of-day Moderate-to-Vigorous Activity (MVPA) and Sedentary (SED) levels, Tanner stage, total weekly sleep time, age (in months), weekly fruit intake, weekly vegetable and legume intake, and intake of sugar-sweetened beverages. DISCUSSION: TimePAD contributes a pipeline for learning from the time-of-day structure in wearable PA time series and integrating it with static dietary and contextual data for prediction and feature analysis. The findings suggest that LPA is likely to have a significant association with HWS, calling for further attention and investigation to better understand the role of LPA in overall health outcomes. This illustrates the potential benefits of TimePAD in modelling PA with dietary intake context in shaping healthy behaviours. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Yu, Xiaotong AU - Yu X AD - School of Computer Science, The University of Sydney, Sydney, NSW 2008, Australia. FAU - Kim, Joshua Y AU - Kim JY AD - School of Computer Science, The University of Sydney, Sydney, NSW 2008, Australia. FAU - Wattelez, Guillaume AU - Wattelez G AD - Institute for Societies, Languages and Education, University of New Caledonia, Noumea, 98800, New Caledonia. FAU - Galy, Olivier AU - Galy O AD - Institute for Societies, Languages and Education, University of New Caledonia, Noumea, 98800, New Caledonia. FAU - Caillaud, Corinne AU - Caillaud C AD - Sydney School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2008, Australia; Charles Perkins Centre, The University of Sydney, Sydney, NSW 2008, Australia. FAU - Yacef, Kalina AU - Yacef K AD - School of Computer Science, The University of Sydney, Sydney, NSW 2008, Australia. Electronic address: kalina.yacef@sydney.edu.au. LA - eng PT - Journal Article DEP - 20260722 PL - United States TA - J Biomed Inform JT - Journal of biomedical informatics JID - 100970413 SB - IM MH - Humans MH - *Data Mining/methods MH - *Exercise MH - Adolescent MH - Child MH - Female MH - *Body Weight MH - Male MH - Accelerometry MH - *Diet MH - Prediction Algorithms MH - Predictive Learning Models OTO - NOTNLM OT - Adolescent healthy weight status OT - Multimodal data integration OT - Physical activity OT - Time-series feature learning OT - Wearable sensor data COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/23 05:36 MHDA- 2026/08/18 23:36 CRDT- 2026/07/22 19:11 PHST- 2026/01/26 00:00 [received] PHST- 2026/07/06 00:00 [revised] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/08/18 23:36 [medline] PHST- 2026/07/23 05:36 [pubmed] PHST- 2026/07/22 19:11 [entrez] AID - S1532-0464(26)00107-3 [pii] AID - 10.1016/j.jbi.2026.105083 [doi] PST - ppublish SO - J Biomed Inform. 2026 Sep;181:105083. doi: 10.1016/j.jbi.2026.105083. Epub 2026 Jul 22. PMID- 42485433 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260722 IS - 1946-6242 (Electronic) IS - 1946-6234 (Linking) VI - 18 IP - 859 DP - 2026 Jul 22 TI - At-home wearable measurements provide detailed growth charts of infant early gross motor development. PG - eadz7035 LID - 10.1126/scitranslmed.adz7035 [doi] AB - Early gross motor performance is a key component of neurodevelopmental assessments, and longitudinal follow-ups in personalized health care need better objective methods for measuring it. We studied how the detailed characteristics of infants' gross motor development could be modeled with age-normative growth charts. We performed serial at-home measurements (total of 580 measurements, 1227 hours of free playtime) from a cohort of 92 typically developing infants at 4 to 19 months of age, using wearable suits with four movement sensors. A previously developed and validated, fully automated analysis pipeline detected postures and movements at a second-by-second resolution, to be used for deriving 220 detailed motor metrics of postures, movements, transition dynamics, locomotion types, and activity counts. The results showed that early gross motor development is sufficiently stable for constructing robust growth charts, most prominently for modeling evolving postures and their dynamics, and a wide range of motor metrics have sufficient temporal stability to provide reliable individual-level tracking. External validation in a clinical cohort with 39 infants, including participants with both typical and abnormal neurodevelopment, showed that the growth charts were highly generalizable (91% of the studied motor metrics were statistically comparable to those of the normative cohort), and 55% of the motor metrics showed statistical differentiation of abnormal neurodevelopment. These findings indicate that measurements of at-home wearables can provide assessments to meet a wide range of needs in health care and developmental science. FAU - Airaksinen, Manu AU - Airaksinen M AUID- ORCID: 0000-0002-8031-2260 AD - BABA Center, Pediatric Research Center, Department of Clinical Neurophysiology, New Children's Hospital and HUS Imaging, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, Finland. AD - Department of Physiology, University of Helsinki, 00290 Helsinki, Finland. AD - Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Systemic Ethology and Developmental Science - SEE, University Hospital Heidelberg, Heidelberg University, 69115 Heidelberg, Germany. FAU - Taylor, Elisa AU - Taylor E AUID- ORCID: 0009-0000-3302-5130 AD - BABA Center, Pediatric Research Center, Department of Clinical Neurophysiology, New Children's Hospital and HUS Imaging, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, Finland. FAU - Palsa, Taru AU - Palsa T AUID- ORCID: 0009-0007-6523-988X AD - BABA Center, Pediatric Research Center, Department of Clinical Neurophysiology, New Children's Hospital and HUS Imaging, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, Finland. FAU - de Sena, Sofie AU - de Sena S AD - BABA Center, Pediatric Research Center, Department of Clinical Neurophysiology, New Children's Hospital and HUS Imaging, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, Finland. FAU - Haataja, Leena AU - Haataja L AUID- ORCID: 0000-0002-8057-6194 AD - BABA Center, Pediatric Research Center, Department of Clinical Neurophysiology, New Children's Hospital and HUS Imaging, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, Finland. AD - Department of Pediatric Neurology, Children's Hospital, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, Finland. FAU - Vanhatalo, Sampsa AU - Vanhatalo S AUID- ORCID: 0000-0002-9771-7061 AD - BABA Center, Pediatric Research Center, Department of Clinical Neurophysiology, New Children's Hospital and HUS Imaging, Helsinki University Hospital and University of Helsinki, 00290 Helsinki, Finland. AD - Department of Physiology, University of Helsinki, 00290 Helsinki, Finland. LA - eng PT - Journal Article DEP - 20260722 PL - United States TA - Sci Transl Med JT - Science translational medicine JID - 101505086 SB - IM MH - Humans MH - Infant MH - *Wearable Electronic Devices MH - *Child Development/physiology MH - Female MH - *Growth Charts MH - Male MH - Posture/physiology MH - Movement/physiology EDAT- 2026/07/22 18:37 MHDA- 2026/07/22 18:38 CRDT- 2026/07/22 14:02 PHST- 2026/07/22 18:38 [medline] PHST- 2026/07/22 18:37 [pubmed] PHST- 2026/07/22 14:02 [entrez] AID - 10.1126/scitranslmed.adz7035 [doi] PST - ppublish SO - Sci Transl Med. 2026 Jul 22;18(859):eadz7035. doi: 10.1126/scitranslmed.adz7035. Epub 2026 Jul 22. PMID- 42485298 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - The relationship between fat talk and body image in Chinese female nursing students: The mediating role of self-acceptance. PG - e0351756 LID - 10.1371/journal.pone.0351756 [doi] LID - e0351756 AB - OBJECTIVE: This study examined whether self-acceptance mediates the relationship between fat talk and body image among Chinese female nursing students, a group under high appearance pressure. METHODS: A cross-sectional survey was conducted among 1,280 female nursing students from five medical universities in Henan Province, China, Participants were recruited from randomly selected classes, and questionnaires were distributed in person via QR codes.. Participants completed validated scales measuring fat talk (Fat Talk Scale), self-acceptance (Self-Acceptance Questionnaire), and body image (Body Image States Scale). Data were analyzed using correlation and mediation analysis (PROCESS macro, Model 4) with bootstrapping. RESULTS: Fat talk was positively correlated with both self-acceptance (r = 0.543, p < 0.001) and body image (r = 0.344, p < 0.001). Self-acceptance was also positively correlated with body image (r = 0.457, p < 0.001). After controlling for "relationship status, grade, only child status, and BMI,Mediation analysis revealed a significant indirect effect of fat talk on body image through self-acceptance (effect = 0.174, 95% CI [0.132, 0.222]), accounting for 57.80% of the total effect (total effect = 0.301). The direct effect remained significant (effect = 0.127, 95% CI [0.032, 0.222]).The standardized indirect effect (beta = 0.080) indicates a small-to-moderate effect size. CONCLUSION: Among Chinese female nursing students, engaging in fat talk conversations is associated with a more positive body image. Self-acceptance accounting for 57.80% of the total effect, though the standardized indirect effect (beta = 0.080) suggests a small-to-moderate effect size. This finding highlights the importance of cultural and contextual factors in shaping body discourse and suggests that fostering supportive communication environments and self-acceptance could be beneficial in this population. CI - Copyright: (c) 2026 Wang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Wang, Fengxia AU - Wang F AUID- ORCID: 0009-0009-6173-1628 AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Wang, Yuxiao AU - Wang Y AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Wang, Yufan AU - Wang Y AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Yang, Qihao AU - Yang Q AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Qiu, Ju AU - Qiu J AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Li, Jinyan AU - Li J AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Liu, Meng AU - Liu M AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Wang, Xiaowei AU - Wang X AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Li, Li AU - Li L AD - Pingdingshan University, Pingdingshan, Henan, China. FAU - Xia, Xichao AU - Xia X AUID- ORCID: 0000-0001-7836-8110 AD - Pingdingshan University, Pingdingshan, Henan, China. LA - eng PT - Journal Article DEP - 20260722 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - Chinese people SB - IM MH - Humans MH - Female MH - *Body Image/psychology MH - *Students, Nursing/psychology MH - China MH - *Self Concept MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Young Adult MH - Adult MH - Body Satisfaction MH - East Asian People PMC - PMC13390842 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/22 18:37 MHDA- 2026/07/22 18:38 PMCR- 2026/07/22 CRDT- 2026/07/22 13:33 PHST- 2026/01/07 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/07/22 18:38 [medline] PHST- 2026/07/22 18:37 [pubmed] PHST- 2026/07/22 13:33 [entrez] PHST- 2026/07/22 00:00 [pmc-release] AID - PONE-D-25-68898 [pii] AID - 10.1371/journal.pone.0351756 [doi] PST - epublish SO - PLoS One. 2026 Jul 22;21(7):e0351756. doi: 10.1371/journal.pone.0351756. eCollection 2026. PMID- 42484163 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260722 IS - 1678-2690 (Electronic) IS - 0001-3765 (Linking) VI - 98 IP - 2 DP - 2026 TI - Analysis of Digital Phenotype for Classification of Self-Reported Anxiety. PG - e20250023 LID - S0001-37652026000202604 [pii] LID - 10.1590/0001-3765202620250023 [doi] AB - Digital phenotypes are behavioral patterns inferred from digital data, which have significantly contributed to eHealth research. Machine learning has proven effective in tracking these patterns; however, psychophysiological variables are still underutilized in identifying digital phenotypes. The objective of this study was to test the machine learning algorithms XGBoost, AdaBoost, RFC, and GaussianNB in classifying digital phenotypes of severe anxiety. Data from 360 volunteers, aged between 18 and 68 years of both sexes, were collected through self-report scales via the Neuropesquisa app, which simultaneously captured psychophysiological data, such as response time, accelerometer, and gyroscope readings. Scores from the DAAS-21 scale were used to identify individuals with severe anxiety. The results indicated that all four algorithms detected the digital phenotype with an accuracy greater than 75%. The RFC and GaussianNB classifiers achieved the highest accuracies, 81.48% and 80.56%, respectively, with f1 scores of 44.4% and 60.38%, and AUCs of 79% and 83% on the ROC curves. We conclude that the GaussianNB algorithm was the most effective in predicting the digital phenotype of severe anxiety. FAU - Meneses, Danilo A DE AU - Meneses DA AUID- ORCID: 0000-0002-1062-3549 AD - Universidade Federal da Paraiba, Centro de Ciencias Humanas, Letras e Artes, Programa de Pos-graduacao em Neurociencia Cognitiva e Comportamento, Cidade Universitaria, Campus I, Castelo Branco, 58051-900 Joao Pessoa, PB, Brazil. FAU - Bonato, Luiggi A B AU - Bonato LAB AUID- ORCID: 0000-0002-4068-2611 AD - Centro Universitario de Joao Pessoa, Department of Computer Science, Rodovia BR-230, Km 22, Agua Fria, 58053-000 Joao Pessoa, PB, Brazil. FAU - Meneses, Douglas A DE AU - Meneses DA AUID- ORCID: 0000-0001-6406-1361 AD - Centro Universitario de Joao Pessoa, Department of Computer Science, Rodovia BR-230, Km 22, Agua Fria, 58053-000 Joao Pessoa, PB, Brazil. FAU - Tavares, Joel Jonathan C AU - Tavares JJC AUID- ORCID: 0000-0001-9634-4884 AD - Universidade Federal da Paraiba, Centro de Ciencias Humanas, Letras e Artes, Programa de Pos-graduacao em Neurociencia Cognitiva e Comportamento, Cidade Universitaria, Campus I, Castelo Branco, 58051-900 Joao Pessoa, PB, Brazil. FAU - Lopez, Luiz Carlos S AU - Lopez LCS AUID- ORCID: 0000-0002-9983-5563 AD - Universidade Federal da Paraiba, Centro de Ciencias Humanas, Letras e Artes, Programa de Pos-graduacao em Neurociencia Cognitiva e Comportamento, Cidade Universitaria, Campus I, Castelo Branco, 58051-900 Joao Pessoa, PB, Brazil. LA - eng PT - Journal Article DEP - 20260720 PL - Brazil TA - An Acad Bras Cienc JT - Anais da Academia Brasileira de Ciencias JID - 7503280 SB - IM MH - Humans MH - Female MH - Classification Algorithms MH - Phenotype MH - Male MH - *Self Report MH - Adult MH - Adolescent MH - Middle Aged MH - *Anxiety/classification MH - Young Adult MH - Aged MH - *Machine Learning MH - Boosting Machine Learning Algorithms MH - Algorithms MH - ROC Curve EDAT- 2026/07/22 12:37 MHDA- 2026/07/22 12:38 CRDT- 2026/07/22 08:46 PHST- 2025/01/07 00:00 [received] PHST- 2025/11/01 00:00 [accepted] PHST- 2026/07/22 12:38 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/22 08:46 [entrez] AID - S0001-37652026000202604 [pii] AID - 10.1590/0001-3765202620250023 [doi] PST - epublish SO - An Acad Bras Cienc. 2026 Jul 20;98(2):e20250023. doi: 10.1590/0001-3765202620250023. eCollection 2026. PMID- 42483876 OWN - NLM STAT- Publisher LR - 20260722 IS - 1533-4287 (Electronic) IS - 1064-8011 (Linking) DP - 2026 Jul 22 TI - Assessing Consumer-Grade BIA for Minimum Wrestling Weight Determination in Boys High School Wrestling. LID - 10.1519/JSC.0000000000005601 [doi] AB - Jagim, AR, Twohey, E, Fields, JB, Shepler, C, and Jones, MT. Assessing consumer-grade BIA for minimum wrestling weight determination in boys high school wrestling. J Strength Cond Res XX(X): 000-000, 2026-Preseason weight certification in high school wrestling requires valid assessment of body fat percentage to calculate a minimum wrestling weight (MWW). Although skinfold (SKF) thickness is the standard method, bioelectrical impedance analysis (BIA) devices are widely used in school settings. The current study evaluated differences in body fat percentage (BF%), MWW, and resultant minimum weight class (MWC) between SKF and a consumer-grade multifrequency BIA (MFBIA) device. Thirty-six high school male wrestlers completed hydration assessment, weigh-in, SKF testing via a three-site model, and MFBIA assessment during a single afternoon session. Body fat percentage, fat-free mass (FFM), MWW, and resulting MWC were calculated according to state-sanctioned weight certification protocols. Estimates of BF% were higher for SKFBF% compared with the MFBIA% (SKF: 12.9 +/- 4.5%; MFBIA: 10.9 +/- 5.5%; p < 0.001), resulting in a mean difference of -2.1 +/- 3.2% (95% CI: -3.1 to -0.9). Skinfold-derived values were lower for MWW (SKF: 62.1 +/- 8.9 kg; MFBIA: 63.8 +/- 10.3 kg; p < 0.001) and FFM (SKF: 57.3 +/- 8.6 kg; MFBIA: 59.3 +/- 9.7 kg; p < 0.001) compared with MFBIA-derived values. This resulted in a mean difference of -1.7 +/- 2.4 kg (95% CI: -2.4 to -0.9) and -2.1 (95% CI: -2.76 to -1.2) for MWW and FFM, respectively. Approximately 56% of athletes (n = 20) were assigned to different MWCs depending on the method used. Although group-level %BF and MWW values were similar, the observed individual-level discrepancies indicate that the current consumer-grade MFBIA device should not be used interchangeably with the state-sanctioned SKF method for weight certification, and that BIA devices intended for regulatory use should be validated against the mandated field method or a laboratory-based criterion measure. CI - Copyright (c) 2026 National Strength and Conditioning Association. FAU - Jagim, Andrew R AU - Jagim AR AD - Exercise and Sport Science Department, University of Wisconsin-La Crosse, La Crosse, Wisconsin. FAU - Twohey, Eric AU - Twohey E AD - Sports Medicine, Olmsted Medical Center, Rochester, Minnesota. FAU - Fields, Jennifer B AU - Fields JB AD - Department of Nutritional Sciences, University of Connecticut, Storrs, Connecticut. FAU - Shepler, Christian AU - Shepler C AD - School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin; and. FAU - Jones, Margaret T AU - Jones MT AD - Sport, Recreation, and Tourism Management, George Mason University, Fairfax, Virginia. LA - eng PT - Journal Article DEP - 20260722 PL - United States TA - J Strength Cond Res JT - Journal of strength and conditioning research JID - 9415084 SB - IM OTO - NOTNLM OT - athlete safety OT - bioelectrical impedance, wrestling, combat sports OT - body composition OT - weight certification EDAT- 2026/07/22 12:37 MHDA- 2026/07/22 12:37 CRDT- 2026/07/22 05:43 PHST- 2026/07/22 12:37 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/22 05:43 [entrez] AID - 00124278-990000000-01137 [pii] AID - 10.1519/JSC.0000000000005601 [doi] PST - aheadofprint SO - J Strength Cond Res. 2026 Jul 22. doi: 10.1519/JSC.0000000000005601. PMID- 42483753 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260722 IS - 2040-1752 (Electronic) IS - 2040-1744 (Linking) VI - 17 DP - 2026 Jul 22 TI - Relative fat mass and myopia in adolescents: a cross-sectional study using NHANES data. PG - e33 LID - 10.1017/S204017442610066X [doi] AB - Adolescence is a peak period for myopia onset, which is closely related to environmental and lifestyle factors. Relative fat mass (RFM), a novel indicator of body fat, provides a more precise measure of adiposity. However, its relationship with myopia in adolescents remains poorly understood. To probe the connection between RFM and myopia in adolescents, this study included 8746 adolescents aged 12-19 years, utilizing data from the National Health and Nutrition Examination Survey (1999-2008). Myopia was defined as a spherical equivalent (SE) perceived family support --> self-efficacy --> physical exercise behavior" was only significant in nuclear families. CONCLUSION: This study reveals the internal mechanism and boundary conditions of the family sports environment influencing junior high school students' physical exercise behavior, and provides theoretical references and practical suggestions for families, schools and communities to jointly construct a sports support network and improve adolescents' physical exercise behavior. CI - Copyright (c) 2026 Zhang, Zhou, Wu, Ren and Fang. FAU - Zhang, Tingxiao AU - Zhang T AD - School of Physical Education, Liaoning Normal University, Dalian, China. FAU - Zhou, Wenlan AU - Zhou W AD - School of Physical Education, Liaoning Normal University, Dalian, China. FAU - Wu, Qi AU - Wu Q AD - School of Physical Education, Liaoning Normal University, Dalian, China. FAU - Ren, Wanyang AU - Ren W AD - School of Physical Education, Liaoning Normal University, Dalian, China. FAU - Fang, Yuxiang AU - Fang Y AD - School of Physical Education, Liaoning Normal University, Dalian, China. LA - eng PT - Journal Article DEP - 20260707 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13386413 OTO - NOTNLM OT - family sports environment OT - junior high school students OT - perceived family support OT - physical exercise behavior OT - self-efficacy OT - the chain mediating effect COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/22 12:37 MHDA- 2026/07/22 12:38 PMCR- 2026/07/07 CRDT- 2026/07/22 04:24 PHST- 2026/03/02 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/22 12:38 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/22 04:24 [entrez] PHST- 2026/07/07 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1821116 [doi] PST - epublish SO - Front Psychol. 2026 Jul 7;17:1821116. doi: 10.3389/fpsyg.2026.1821116. eCollection 2026. PMID- 42482093 OWN - NLM STAT- MEDLINE DCOM- 20261021 LR - 20261023 IS - 1750-1172 (Electronic) IS - 1750-1172 (Linking) VI - 21 IP - 1 DP - 2026 Jul 21 TI - Eating behaviour phenotype in the MYT1L-related neurodevelopmental disorder: a deep phenotyping study using standardized questionnaires. LID - 10.1186/s13023-026-04497-x [doi] LID - 368 AB - BACKGROUND: The MYT1L-related neurodevelopmental disorder (MRND) is associated with global motor and language delay, intellectual disability, behavioural disturbances, epilepsy and frequent early-onset obesity. Eating disturbances have been reported but remain poorly characterized. A systematic characterization of the eating behaviour phenotype is essential to improve diagnosis and management. METHODS: We conducted a multicentre study including 21 French-speaking individuals with a molecularly confirmed MRND and either overweight/obesity or eating behaviour disturbances. Eating behaviours were reported by relatives using validated questionnaires widely employed in rare obesity research: the Dykens Hyperphagia Questionnaire (HQ), the Trousseau Impulsivity Questionnaire, the Children's Eating Behaviour Questionnaire (CEBQ), the Food Cravings Questionnaire-Trait-reduced (FCQ-T-r, adults only), and a Visual Analogue Scale (VAS) for hunger. When available, questionnaire results were compared with published studies using the same instruments. RESULTS: Persistent hyperphagic behaviours were identified in the majority of patients, with the HQ questionnaire highlighting sustained food-seeking behaviours and pervasive food preoccupation. The mean global score was 25.9, indicating a moderate yet sustained hyperphagic profile. CEBQ revealed a strong attraction to food combined with reduced satiety responsiveness and rapid eating. Hunger was reported as persistent throughout the day. In children food impulsivity was less frequent (5/14; 36%) and no correlation was found between impulsivity and hyperphagia severity, contrasting with findings in other obesity syndromes. Among adults, 62.5% had scores suggestive of food addiction (FCQ-T-r >/= 50). CONCLUSION: This study delineates an eating behaviour profile in a symptom-enriched subgroup of individuals with MRND, characterized by moderate but sustained hyperphagia, persistent hunger, impaired satiety, low food-related impulsivity in children but frequent food craving/addiction in adults. These findings support early, age-adapted and multidisciplinary management strategies and highlight the need for targeted interventions to reduce the burden on affected individuals and families. CI - (c) 2026. The Author(s). FAU - Coursimault, Juliette AU - Coursimault J AD - Department of Genetics and Reference Center for Developmental Disorders, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Rouen, F-76000, France. j.coursimault@chu-rouen.fr. FAU - Guillon, Emilie AU - Guillon E AD - Nutrition Department, Reference Center for Rare Diseases PRADORT, Assistance Publique Hopitaux de Paris, Pitie-Salpetriere Hospital, Paris, France. AD - Sorbonne Universite, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmique Research Group, Paris, France. FAU - Lecoquierre, Francois AU - Lecoquierre F AD - Department of Genetics and Reference Center for Developmental Disorders, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Rouen, F-76000, France. FAU - Charbonnier, Camille AU - Charbonnier C AD - Department of Genetics and Reference Center for Developmental Disorders, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Rouen, F-76000, France. FAU - Guerrot, Anne-Marie AU - Guerrot AM AD - Department of Genetics and Reference Center for Developmental Disorders, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Rouen, F-76000, France. FAU - Goldenberg, Alice AU - Goldenberg A AD - Department of Genetics and Reference Center for Developmental Disorders, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Rouen, F-76000, France. FAU - Nicolas, Gael AU - Nicolas G AD - Department of Genetics and Reference Center for Developmental Disorders, Univ Rouen Normandie, Normandie Univ, Inserm U1245 and CHU Rouen, Rouen, F-76000, France. FAU - Schaefer, Elise AU - Schaefer E AD - Service de Genetique Medicale, Institut de Genetique Medicale d'Alsace (IGMA), Hopitaux Universitaires de Strasbourg, Strasbourg, France. FAU - Ayrolles, Anael AU - Ayrolles A AD - Department of Child and Adolescent Psychiatry, APHP.Nord, Robert Debre University Hospital, Paris Cite University, Paris, France. FAU - Delorme, Richard AU - Delorme R AD - Department of Child and Adolescent Psychiatry, APHP.Nord, Robert Debre University Hospital, Paris Cite University, Paris, France. FAU - Riccardi, Florence AU - Riccardi F AD - Genetique Medicale, Centre Hospitalier Intercommunal Toulon - La Seyne- sur-Mer, Toulon, France. FAU - Grelet, Maude AU - Grelet M AD - Genetique Medicale, Centre Hospitalier Intercommunal Toulon - La Seyne- sur-Mer, Toulon, France. FAU - Caumes, Roseline AU - Caumes R AD - Universite de Lille, CHU de Lille, Clinique de Genetique <>, EA7364 RADEMEF-59000, Lille, France. FAU - Nizon, Mathilde AU - Nizon M AD - Service de Genetique Medicale, CHU Nantes, Nantes, France. FAU - Isidor, Bertrand AU - Isidor B AD - Service de Genetique Medicale, CHU Nantes, Nantes, France. FAU - Jouret, Guillaume AU - Jouret G AD - National Center of Genetics (NCG), Laboratoire National de Sante (LNS), Dudelange, L- 3555, Luxembourg. FAU - Rooryck, Caroline AU - Rooryck C AD - Univ. Bordeaux, MRGM INSERM U1211, CHU de Bordeaux, Service de Genetique Medicale, Bordeaux, F-33000, France. FAU - Amiel, Jeanne AU - Amiel J AD - Service de Medecine Genomique des Maladies Rares, Hopital Necker- Enfants Malades, AP-HP, Paris, France. FAU - Alaix, Anne-Sophie AU - Alaix AS AD - Service de Medecine Genomique des Maladies Rares, Hopital Necker- Enfants Malades, AP-HP, Paris, France. FAU - Morel, Victor AU - Morel V AD - Department of Medical Genetics, La Timone Hospital, AP-HM, La Timone Children's Hospital, Marseille, France. FAU - Jacquinet, Adeline AU - Jacquinet A AD - Department of Genetics, Sart Tilman University Hospital, Liege, Belgium. FAU - Mignot, Cyril AU - Mignot C AD - Departement de Genetique, Groupe Hospitalier Pitie-Salpetriere-Hopital Trousseau Centre de Reference Deficiences Intellectuelles de Causes Rares, APHP.Sorbonne Universite, Paris, France. FAU - Faivre, Laurence AU - Faivre L AD - Universite Bourgogne Europe, CHU Dijon Bourgogne, Inserm, CTM UMR1231, equipe GAD, FHU TRANSLAD, Centre de genetique, Centre de reference Anomalies du Developpement et Syndromes Malformatifs, Centre de reference Deficiences Intellectuelles de Causes Rares, et Centre de reference GenoPsy, Dijon, 21000, France. FAU - Fraile-Caietta, Emilie AU - Fraile-Caietta E AD - Service de pediatrie, Centre Hospitalier de Toulon, Toulon, France. FAU - Chalopin, Sarah AU - Chalopin S AD - Nutrition Department, Reference Center for Rare Diseases PRADORT, Assistance Publique Hopitaux de Paris, Pitie-Salpetriere Hospital, Paris, France. AD - Sorbonne Universite, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmique Research Group, Paris, France. FAU - Dubern, Beatrice AU - Dubern B AD - Sorbonne Universite, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmique Research Group, Paris, France. AD - Nutrition and Gastroenterology Department, Reference Center for Rare Diseases PRADORT, Assistance Publique Hopitaux de Paris, Trousseau Hospital, Paris, France. FAU - Poitou, Christine AU - Poitou C AD - Nutrition Department, Reference Center for Rare Diseases PRADORT, Assistance Publique Hopitaux de Paris, Pitie-Salpetriere Hospital, Paris, France. AD - Sorbonne Universite, Inserm, Nutrition and Obesities: Systemic Approaches, NutriOmique Research Group, Paris, France. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260721 PL - England TA - Orphanet J Rare Dis JT - Orphanet journal of rare diseases JID - 101266602 SB - IM MH - Humans MH - Female MH - Surveys and Questionnaires MH - *Feeding Behavior/physiology MH - *Neurodevelopmental Disorders/genetics/physiopathology/metabolism MH - Child MH - Male MH - Phenotype MH - Adult MH - Hyperphagia/genetics MH - Child, Preschool MH - Adolescent MH - Obesity/genetics MH - Feeding and Eating Disorders/genetics MH - Young Adult PMC - PMC13685170 OTO - NOTNLM OT - MYT1L haploinsufficiency OT - 2p25.3 deletion OT - Deep phenotypic characterization OT - Dykens OT - Eating behaviours OT - Rare disease OT - Standardized questionnaires OT - Syndromic obesity COIS- Declarations. Ethics approval and consent to participate: All patients gave their consent to participate in the study. This study expands on the 2022 cohort published by Coursimault et al., approved by the Institutional Review Board of the Rouen University Hospital (CERDE, Comite d'Ethique pour la Recherche sur Donnees Existantes et Hors Loi Jarde, Rouen, France) (notification n degrees 69-2020). Some patients were included as part of the French Rare Obesity Cohorts With Food Behavioural Disorders: Better Diagnosis for Better Treatment (ObeRare) cohort (NCT04604626). Consent for publication: Not applicable. Competing interests: JC has nothing to disclose. All other collaborators do not have anything to disclose. BD has nothing to disclose. Rhythm Pharmaceuticals provided financial support for data entry in the ObeRar database but had no role in the scientific aspects of the study, including data analysis, results, or their interpretation. EDAT- 2026/07/22 12:37 MHDA- 2026/10/21 05:32 PMCR- 2026/07/21 CRDT- 2026/07/21 23:50 PHST- 2026/10/21 05:32 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/21 23:50 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - 10.1186/s13023-026-04497-x [pii] AID - 4497 [pii] AID - 10.1186/s13023-026-04497-x [doi] PST - epublish SO - Orphanet J Rare Dis. 2026 Jul 21;21(1):368. doi: 10.1186/s13023-026-04497-x. PMID- 42481992 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261022 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 21 TI - Targeting childhood malaria: insights from multi-country DHS data in Sub-Saharan Africa. LID - 10.1186/s12887-026-07245-z [doi] LID - 1021 AB - BACKGROUND: Malaria remains a major public health challenge in sub-Saharan Africa, disproportionately affecting children under five and pregnant women. Understanding the socio-demographic and maternal determinants of malaria across multiple countries is critical for designing targeted interventions such as Targeted Drug Administration (TDA), Perennial Malaria Chemoprevention (PMC), Seasonal Malaria Chemoprevention (SMC), Vector Control and Epidemiological Mapping. This study aimed to assess the prevalence and determinants of malaria infection among children under five across seven sub-Saharan African countries and to identify country-specific risk factors. METHODS: A cross-sectional analytical study used secondary data from the most recent Demographic and Health Surveys (DHS-8) for Burkina Faso, Cote d'Ivoire, Kenya, Mozambique, Senegal, Tanzania, and for Cameroon, Malaria Indicator Surveys (MIS-8) was used. Two outcome measures were defined: malaria infection based on rapid diagnostic test (RDT) results (five countries: Burkina Faso, Cote d'Ivoire, Mozambique, Tanzania and Cameroon) and maternal self-report (seven countries: Burkina Faso, Cote d'Ivoire, Kenya, Mozambique, Senegal, Tanzania and Cameroon). The data were analyzed using Stata/SE 17.0 and the analytic samples included 20,323 mother-child pairs for RDT analysis and 12,457 for self-reported analysis. The study examined socio-demographic and maternal characteristics, including residence, wealth index, education, parity, body mass index (BMI), and pregnancy status. Analyses incorporated sampling weights and survey design. Descriptive statistics, chi-square tests, and country-specific multivariable logistic regression models were used to identify independent predictors. RESULTS: Malaria prevalence was higher by self-report (33.5%) than by RDT diagnosis (25.2%), with consistently higher self-reported estimates across Tanzania (31.7% vs. 6.9%), Burkina Faso (58.3% vs. 27.4%), and Cote d'Ivoire (47.1% vs. 36.9%). RDT-confirmed malaria showed stronger and more consistent associations with key risk factors, including rural residence (in Burkina Faso aOR = 3.58, in Cote d'Ivoire aOR = 3.64, in Mozambique aOR = 5.74, in Tanzania aOR = 12.70; all p < 0.001), wealth status has lower malaria risk (richest quintile: Burkina Faso aOR = 0.43, Cote d'Ivoire aOR = 0.26, Mozambique aOR = 0.14, Tanzania aOR = 0.27), and while pregnancy status has significant risk (in Burkina Faso p = 0.008, in Cote d'Ivoire p = 0.005, in Cameroon p = 0.006, and in Mozambique p < 0.001), compared with weaker and sometimes inconsistent self-reported associations. The RDT- malaria diagnosis produced more plausible and statistically robust associations (in Mozambique age 25-34: aOR = 1.32, p = 0.040; in Burkina Faso parity two births: aOR = 1.33, p < 0.001), whereas self-reported malaria showed weaker or contradictory effects suggesting potential misclassification and reporting bias in self-reported diagnosis. CONCLUSION: This study demonstrates that important methodological and epidemiological differences exist between self-reported malaria and malaria RDT diagnosis across sub-Saharan African countries. Self-reported malaria showed overestimated malaria prevalence and produced weaker and less consistent associations with established risk factors, indicating limited reliability for identifying true malaria infection patterns. In contrast, malaria RDT diagnosis generated more coherent and epidemiologically plausible associations with rural residence, socioeconomic status, nutritional status, and pregnancy, reflecting more accurately the biological and environmental determinants of malaria transmission. CI - (c) 2026. The Author(s). FAU - Konja, Benjamin Akwasi AU - Konja BA AD - Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. FAU - Agyapong, Nana Ama Frimpomaa AU - Agyapong NAF AD - Department of Clinical Nutrition and Dietetics, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. FAU - Ocran, Emmanuel Kweku AU - Ocran EK AD - Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. FAU - Anyimadu, Gloria AU - Anyimadu G AD - Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. FAU - Agyapong, Livingstone AU - Agyapong L AD - Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. FAU - Asare, Kwame Kumi AU - Asare KK AD - Biomedical and Clinical Research Centre, College of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana. kwame.asare@ucc.edu.gh. AD - Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana. kwame.asare@ucc.edu.gh. LA - eng PT - Journal Article DEP - 20260721 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 0 (Antimalarials) SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Infant MH - Prevalence MH - *Malaria/epidemiology/prevention & control/diagnosis MH - Child, Preschool MH - Risk Factors MH - Male MH - Africa South of the Sahara/epidemiology MH - Adult MH - Secondary Data Analysis MH - Pregnancy MH - Health Surveys MH - Antimalarials/therapeutic use MH - Young Adult PMC - PMC13681905 OTO - NOTNLM OT - Children under five OT - DHS OT - Malaria OT - Multi-country analysis OT - Socio-demographic determinants OT - Sub-Saharan Africa COIS- Declarations. Ethics approval and consent to participate: The DHS surveys obtain ethical approval from the Institutional Review Board (IRB) of ICF and relevant national ethics committees in participating countries. Informed consent is obtained from all respondents prior to participation. This study utilized publicly available, de-identified secondary data obtained from the DHS Program upon formal request and approval. As the data contain no personal identifiers, additional ethical approval was not required for this secondary analysis. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/22 12:37 MHDA- 2026/10/20 05:30 PMCR- 2026/07/21 CRDT- 2026/07/21 23:45 PHST- 2026/03/14 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/10/20 05:30 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/21 23:45 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - 10.1186/s12887-026-07245-z [pii] AID - 7245 [pii] AID - 10.1186/s12887-026-07245-z [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 21;26(1):1021. doi: 10.1186/s12887-026-07245-z. PMID- 42480810 OWN - NLM STAT- Publisher LR - 20260909 IS - 1873-4332 (Electronic) IS - 1083-3188 (Linking) DP - 2026 Jul 21 TI - Systemic Immune-Inflammation Indices in Adolescents with Polycystic Ovary Syndrome (Recently Proposed as Polyendocrine Metabolic Ovarian Syndrome): Evidence from Obese and Nonobese Phenotypes. LID - S1083-3188(26)00456-0 [pii] LID - 10.1016/j.jpag.2026.07.008 [doi] AB - PURPOSE: This study aimed to evaluate the systemic immune-inflammation index (SII) and pan-immune-inflammation value (PIV) in adolescents with polycystic ovary syndrome (PCOS) and to investigate whether these markers reflect an inflammatory state independent of obesity. METHODS: A total of 140 adolescents (64 PCOS, 76 controls) were included. The groups were further subdivided based on BMI percentiles into obese (Group 1a: PCOS-obese, Group 2a: Control-obese) and nonobese (Group 1b: PCOS-nonobese, Group 2b: Control-nonobese) subgroups. Diagnosis of PCOS was based on the 2023 international evidence-based guidelines for adolescents. SII and PIV were calculated from complete blood count parameters. RESULTS: SII and PIV levels were significantly higher in the PCOS group compared to controls (P = .001 and P = .004, respectively). In subgroup analysis, SII remained significantly elevated in nonobese PCOS patients compared to nonobese controls (582.39 +/- 276.52 vs 406.44 +/- 116.73, P = .001). Multivariate logistic regression analysis identified SII as an independent predictor for PCOS (P = .019). Receiver operating characteristic analysis showed moderate diagnostic performance for SII (area under the curve [AUC]: 0.672) and PIV (AUC: 0.655). CONCLUSION: SII and PIV are elevated in adolescent PCOS independently of obesity, particularly in the nonobese phenotype. These cost-effective, hemogram-derived indices provide a valuable clinical snapshot of the systemic inflammatory burden and may provide insight into the inflammatory milieu associated with PCOS in adolescence for future metabolic complications. CI - Copyright (c) 2026 North American Society for Pediatric and Adolescent Gynecology. Published by Elsevier Inc. All rights reserved. FAU - Ciftci, Nurdan AU - Ciftci N AD - Department of Pediatrics Endocrinology, Konya City Hospital, Konya, Turkiye. Electronic address: pediatrinurdan@gmail.com. FAU - Akin, Sule Betul Nursacan AU - Akin SBN AD - Department of Pediatrics, Konya City Hospital, Konya, Turkiye. FAU - Dogan, Dilara AU - Dogan D AD - Department of Pediatrics, Konya City Hospital, Konya, Turkiye. FAU - Gulyuz, Abdulgani AU - Gulyuz A AD - Department of Pediatrics, Malatya Training and Research Hospital, Malatya, Turkiye. LA - eng PT - Journal Article DEP - 20260721 PL - United States TA - J Pediatr Adolesc Gynecol JT - Journal of pediatric and adolescent gynecology JID - 9610774 SB - IM OTO - NOTNLM OT - Adolescent OT - Obesity OT - PCOS OT - PIV OT - PMOS OT - SII COIS- Conflicts of Interest The authors have no relevant financial or nonfinancial interests to disclose. EDAT- 2026/07/22 12:37 MHDA- 2026/07/22 12:37 CRDT- 2026/07/21 19:12 PHST- 2026/04/29 00:00 [received] PHST- 2026/07/10 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/22 12:37 [medline] PHST- 2026/07/21 19:12 [entrez] AID - S1083-3188(26)00456-0 [pii] AID - 10.1016/j.jpag.2026.07.008 [doi] PST - aheadofprint SO - J Pediatr Adolesc Gynecol. 2026 Jul 21:S1083-3188(26)00456-0. doi: 10.1016/j.jpag.2026.07.008. PMID- 42480688 OWN - NLM STAT- MEDLINE DCOM- 20260905 LR - 20260905 IS - 1873-6351 (Electronic) IS - 0278-6915 (Linking) VI - 217 DP - 2026 Nov TI - Cannabis-derived food products: a global review of THC exposure, safety and forensic frameworks. PG - 116285 LID - S0278-6915(26)00359-5 [pii] LID - 10.1016/j.fct.2026.116285 [doi] AB - Cannabis-derived food products range from nutritionally oriented hempseed foods to edible and drinkable products intentionally formulated with cannabinoids. This review integrates evidence on hemp foods, CBD-containing products, THC edibles, cannabis-infused beverages, and emerging cannabinoids such as Delta8-THC and HHC. Hemp seeds, oils, flours, and proteins provide valuable nutrients, including polyunsaturated fatty acids, proteins, fiber, minerals, and bioactive compounds, but require control of cannabinoid contamination, particularly total Delta9-THC. In contrast, cannabinoid-containing edibles act as pharmacologically active food-like exposure systems. Oral Delta9-THC presents a distinct toxicological profile characterized by delayed onset, prolonged effects, first-pass metabolism, formation of active 11-hydroxy-THC, and high interindividual variability. These features increase the risk of repeated dosing, unexpected intoxication, accidental pediatric exposure, emergency presentations, and forensic interpretation challenges. CBD products raise safety concerns related to dose, purity, liver effects, drug interactions, and vulnerable populations, while Delta8-THC, HHC, and related cannabinoids introduce additional uncertainty due to limited toxicological data and inconsistent regulation. Harmonized definitions, validated analytical methods, reliable labeling, child-resistant packaging, adverse-event surveillance, and dose-based regulation are needed to protect consumers and support public safety. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Jurowski, Kamil AU - Jurowski K AD - Department of Toxicology, Faculty of Medicine, Collegium Medicum, University of Rzeszow, al. Tadeusza Rejtana 16C, Rzeszow, 35-959, Poland; Department of Regulatory and Forensic Toxicology, Institute of Medical Expertise, ul. Aleksandrowska 67/93, Lodz, 91-205, Poland; Laboratory of Toxicological Research and Analyses, Faculty of Medicine, Collegium Medicum, University of Rzeszow, Al. mjr. W. Kopisto 2a, Rzeszow, 35-959, Poland; Centre for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove, CZ-500 03, Czech Republic. Electronic address: toksykologia@ur.edu.pl. FAU - Noga, Maciej AU - Noga M AD - Department of Toxicology, Faculty of Medicine, Collegium Medicum, University of Rzeszow, al. Tadeusza Rejtana 16C, Rzeszow, 35-959, Poland. FAU - Kobylarz, Damian AU - Kobylarz D AD - Department of Toxicology, Faculty of Medicine, Collegium Medicum, University of Rzeszow, al. Tadeusza Rejtana 16C, Rzeszow, 35-959, Poland. FAU - Niznik, Lukasz AU - Niznik L AD - Department of Toxicology, Faculty of Medicine, Collegium Medicum, University of Rzeszow, al. Tadeusza Rejtana 16C, Rzeszow, 35-959, Poland. FAU - Machlanska, Agnieszka AU - Machlanska A AD - Department of Forensic Medical Traumatology, Institute of Medical Expertise, ul. Aleksandrowska 67/93, Lodz, 91-205, Poland. FAU - Nepovimova, Eugenie AU - Nepovimova E AD - Center of Advanced Innovation Technologies, VSB-Technical University of Ostrava, Ostrava-Poruba, 708 00, Czech Republic; Department of Chemistry, Faculty of Science, University of Hradec Kralove, Hradec Kralove, 50003, Czech Republic. FAU - Kuca, Kamil AU - Kuca K AD - Centre for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove, CZ-500 03, Czech Republic; Center of Advanced Innovation Technologies, VSB-Technical University of Ostrava, Ostrava-Poruba, 708 00, Czech Republic; Biomedical Research Center, University Hospital Hradec Kralove, Hradec Kralove, 50005, Czech Republic. LA - eng PT - Journal Article PT - Review DEP - 20260721 PL - England TA - Food Chem Toxicol JT - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JID - 8207483 RN - 7J8897W37S (Dronabinol) RN - 0 (Cannabinoids) SB - IM MH - Humans MH - *Cannabis/chemistry MH - *Dronabinol/analysis/toxicity MH - Cannabinoids/analysis/toxicity MH - Animals MH - Food Contamination/analysis OTO - NOTNLM OT - Cannabinoids OT - Cannabis-derived foods OT - Edible cannabis OT - Food safety OT - Forensic toxicology OT - Toxicology OT - Delta9-THC COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Kamil Jurowski reports a relationship with Elsevier Inc that includes: board membership. I serve as Managing Editor for RIFM submissions in Food and Chemical Toxicology. I was not involved in the editorial handling, peer review, or decision-making process for this manuscript. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/22 12:37 MHDA- 2026/09/06 01:18 CRDT- 2026/07/21 19:11 PHST- 2026/06/05 00:00 [received] PHST- 2026/07/17 00:00 [revised] PHST- 2026/07/18 00:00 [accepted] PHST- 2026/09/06 01:18 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/21 19:11 [entrez] AID - S0278-6915(26)00359-5 [pii] AID - 10.1016/j.fct.2026.116285 [doi] PST - ppublish SO - Food Chem Toxicol. 2026 Nov;217:116285. doi: 10.1016/j.fct.2026.116285. Epub 2026 Jul 21. PMID- 42480622 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260825 IS - 1872-9649 (Electronic) IS - 1568-1637 (Linking) VI - 121 DP - 2026 Oct TI - Microbiome remodeling during aging: Integrative multi-omics and spatiotemporal perspectives on immune and metabolic regulation. PG - 103269 LID - S1568-1637(26)00261-8 [pii] LID - 10.1016/j.arr.2026.103269 [doi] AB - Changes in the gut microbiota occur throughout the human lifespan, and maintaining microbial homeostasis plays a critical role in promoting healthy aging. In recent years, substantial progress has been made in elucidating the mechanistic links between aging and microbiota remodeling, highlighting the central role of microbiota-host interactions in regulating immune responses and maintaining metabolic homeostasis. These findings provide new potential targets for the precision prevention and treatment of age-related diseases. This review systematically summarizes the patterns of gut microbiota succession across different stages of the human life cycle, including infancy, adolescence, adulthood, and old age, as well as the mechanisms through which the microbiota regulates immune and metabolic functions. Furthermore, the role of the gut microbiota as a key mediator linking aging with an increased risk of chronic inflammation, cardiovascular disease, cognitive impairment, neurodegenerative disorders, and cancer was explored. In addition, this review evaluates the therapeutic potential of microbiota-targeted interventions, such as dietary modification, probiotic and prebiotic supplementation, fecal microbiota transplantation (FMT), and lifestyle interventions-in maintaining microbiome homeostasis and mitigating age-related diseases. The feasibility of personalized microbiota-based intervention strategies is also discussed. Finally, we highlight the current challenges and limitations in this field and outline future research directions. In particular, integrating multi-omics approaches with metagenomic sequencing, including emerging spatial and spatiotemporal multi-omics technologies, is crucial for advancing our understanding of the complex interactions within the gut microbiome. These insights provide a theoretical framework for optimizing anti-aging therapeutic strategies and promoting healthy lifespan extension. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Ren, Xinyue AU - Ren X AD - Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. FAU - Ma, Jingwen AU - Ma J AD - College of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning, China. FAU - Zhao, Yijie AU - Zhao Y AD - Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. FAU - Yang, Mingyu AU - Yang M AD - College of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning, China. FAU - Li, Yilin AU - Li Y AD - College of Laboratory Medicine, Dalian Medical University, Dalian, Liaoning, China. FAU - Song, Wei AU - Song W AD - Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. FAU - Wang, Nan AU - Wang N AD - Department of Clinical Laboratory Medicine, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China. Electronic address: wangnanlab@163.com. LA - eng PT - Journal Article PT - Review DEP - 20260721 PL - England TA - Ageing Res Rev JT - Ageing research reviews JID - 101128963 SB - IM MH - Humans MH - *Aging/immunology/metabolism MH - Multiomics MH - *Gastrointestinal Microbiome/physiology/immunology MH - Animals MH - Homeostasis OTO - NOTNLM OT - Aging OT - Gut microbiota OT - Intervention OT - Probiotics COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/22 12:37 MHDA- 2026/08/25 23:33 CRDT- 2026/07/21 19:10 PHST- 2026/05/06 00:00 [received] PHST- 2026/06/22 00:00 [revised] PHST- 2026/07/20 00:00 [accepted] PHST- 2026/08/25 23:33 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/21 19:10 [entrez] AID - S1568-1637(26)00261-8 [pii] AID - 10.1016/j.arr.2026.103269 [doi] PST - ppublish SO - Ageing Res Rev. 2026 Oct;121:103269. doi: 10.1016/j.arr.2026.103269. Epub 2026 Jul 21. PMID- 42480192 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260905 IS - 1879-1484 (Electronic) IS - 0021-9150 (Linking) VI - 420 DP - 2026 Sep TI - Universal paediatric screening for familial hypercholesterolaemia: Lessons learnt from our pilot study EARLIE. PG - 120838 LID - S0021-9150(26)00204-2 [pii] LID - 10.1016/j.atherosclerosis.2026.120838 [doi] AB - BACKGROUND AND AIMS: Universal screening for familial hypercholesterolaemia (FH) has been proposed; but implementation remains limited. This pilot study assesses the feasibility and efficacy of a screening based on a capillary blood test in children during a school medical visit. Additionally, we review published screening strategies and cut-off values. METHODS: Screening consisted of a questionnaire and capillary blood test in children aged 7-12 years. Further diagnostic work-up (fasting blood test under low-cholesterol diet and genetic analysis) was proposed if total cholesterol (TC) > 230 mg/dL (>5.9 mmol/L) and/or low-density lipoprotein cholesterol (LDL) > 160 mg/dL (>4.1 mmol/L). If FH was confirmed, the child was commenced on lipid-lowering therapy, and reverse cascade screening was performed within the family. RESULTS: 1860 children of 3733 invited children participated (49.8%). 30 refused the blood test (1.6%). Median TC was 158 mg/dL (4.1 mmol/L; Q25/75,141/174 [3.6/4.5]; P99 230 [5.9]); median LDL 74 mg/dL (1.9 mmol/L; 61/89 [1.6/2.3]; 139 [3.6]). Recall rate 1%. In the sub-cohort with LDL >160 mg/dL (>4.1 mmol/L), (n = 6): detection of three pathogenic variants and five additional affected family members, while three declined further follow-up. CONCLUSIONS: FH screening based on a capillary lipid panel is an efficient screening method. However, 50% of highly suspicious cases declined further follow-up. We therefore advocate screening in the presence of parents to allow discussion of the results and explanation of further diagnostic work-up and long-term health risks. Cut-off levels should be adapted to the methodology used and re-evaluated during the course of the screening programme. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Becker, Marianne AU - Becker M AD - Department of Paediatric Endocrinology and Diabetology, Centre Hospitalier de Luxembourg, Luxembourg; Vitality Research Group, Vrije Universiteit Brussel, Brussels, Belgium. Electronic address: becker.marianne@chl.lu. FAU - Bocquet, Valery AU - Bocquet V AD - Competence Center for Methodology and Statistics, Luxembourg Institute of Health, Luxembourg. FAU - Fandel, Francoise AU - Fandel F AD - Department of School Medicine, City of Luxembourg, Luxembourg. FAU - Adamski, Aurelie AU - Adamski A AD - Department of Paediatric Endocrinology and Diabetology, Centre Hospitalier de Luxembourg, Luxembourg. FAU - Vaillant, Michel AU - Vaillant M AD - Competence Center for Methodology and Statistics, Luxembourg Institute of Health, Luxembourg. FAU - Wagner, Kerstin AU - Wagner K AD - Department of Paediatric Cardiology, Centre Hospitalier de Luxembourg, Luxembourg. FAU - Droste, Dirk W AU - Droste DW AD - Department of Neurology, Centre Hospitalier de Luxembourg, Luxembourg. FAU - Hein, Steve AU - Hein S AD - Department of Sports Medicine, Centre Hospitalier de Luxembourg, Luxembourg. FAU - Gies, Inge AU - Gies I AD - Vitality Research Group, Vrije Universiteit Brussel, Brussels, Belgium; Department of Paediatrics, Universitair Ziekenhuis Brussel, Brussels, Belgium. FAU - Mendon, Priyanka AU - Mendon P AD - Competence Center for Methodology and Statistics, Luxembourg Institute of Health, Luxembourg. FAU - de Beaufort, Carine AU - de Beaufort C AD - Department of Paediatric Endocrinology and Diabetology, Centre Hospitalier de Luxembourg, Luxembourg; Faculty of Science, Technology and Medicine, University of Luxemburg, Esch-Belval, Luxembourg. LA - eng PT - Journal Article DEP - 20260714 PL - Ireland TA - Atherosclerosis JT - Atherosclerosis JID - 0242543 RN - 0 (Cholesterol, LDL) RN - 0 (Biomarkers) RN - 97C5T2UQ7J (Cholesterol) SB - IM MH - Humans MH - Child MH - Pilot Projects MH - *Hyperlipoproteinemia Type II/diagnosis/blood/genetics MH - Male MH - Female MH - Cholesterol, LDL/blood MH - *Mass Screening/methods MH - Surveys and Questionnaires MH - Biomarkers/blood MH - Feasibility Studies MH - Cholesterol/blood MH - Predictive Value of Tests MH - Genetic Predisposition to Disease MH - Genetic Testing OTO - NOTNLM OT - Familial hypercholesterolaemia OT - Paediatric screening OT - Universal screening COIS- Declaration of competing interest MB received travel grants from Novo Nordisk and Kyowa Kirin and honoraria for lectures from Novo Nordisk. IG, DD, AA, KW, MV, VB, PM, FF, SH and CdB have nothing to declare. EDAT- 2026/07/22 12:37 MHDA- 2026/08/28 11:40 CRDT- 2026/07/21 18:02 PHST- 2026/01/13 00:00 [received] PHST- 2026/06/27 00:00 [revised] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/08/28 11:40 [medline] PHST- 2026/07/22 12:37 [pubmed] PHST- 2026/07/21 18:02 [entrez] AID - S0021-9150(26)00204-2 [pii] AID - 10.1016/j.atherosclerosis.2026.120838 [doi] PST - ppublish SO - Atherosclerosis. 2026 Sep;420:120838. doi: 10.1016/j.atherosclerosis.2026.120838. Epub 2026 Jul 14. PMID- 42479927 OWN - NLM STAT- MEDLINE DCOM- 20260721 LR - 20260824 IS - 1744-6171 (Electronic) IS - 1073-6077 (Print) IS - 1073-6077 (Linking) VI - 39 IP - 3 DP - 2026 Aug TI - A Mobile Application to Improve Mental Health and Reduce Suicidal Ideation Among Adolescents: A Pilot Mixed-Methods Study. PG - e70064 LID - 10.1111/jcap.70064 [doi] LID - e70064 AB - BACKGROUND: Adolescent suicidal ideation is a critical public health issue, with limited support options in low-resource settings. PURPOSE: This study aimed to evaluate the acceptability, usability, and preliminary effects of Emo-Safe, an Android-based application designed to enhance emotional regulation and reduce suicidal ideation among adolescents. METHODOLOGY: This study utilized a sequential, explanatory mixed-methods approach, consisting of quantitative followed by qualitative methods. Sixty students, aged 15-18, participated in the study, divided into an intervention group (n = 30) and a control group (n = 30) for 4 weeks. Core app features included daily mood tracking, reflective journaling with AI-assisted reframing guided by cognitive-behavioral therapy (CBT) principles, breathing exercises, personalized insights, and an AI "friend" for encouragement. Outcomes measured were the Indonesian Depression Anxiety Stress Scales for Youth (IDASS-Y) and the Suicidal Ideation Scale (SIS). RESULT: Results indicated that the intervention group had significantly lower post-test IDASS-Y scores (28.43 vs. 33.17; p = 0.037) and reduced stress levels (8.83 vs. 12.37; p = 0.001). The SIS also favored the intervention group (14.83 vs. 21.70; p < 0.001). Acceptability was high (mean rating 4.24/5) with positive feedback on material clarity and facilitator effectiveness, along with suggestions for improvements. CONCLUSIONS: Findings demonstrate the acceptability and usability of Emo-Safe, alongside promising short-term reductions in stress and suicidal ideation. However, further systematic evaluation of broader feasibility indicators, such as recruitment and long-term engagement, is needed in future trials. CI - (c) 2026 Wiley Periodicals LLC. FAU - Mundakir AU - Mundakir AUID- ORCID: 0000-0003-2255-3514 AD - Department of Nursing, Faculty of Health Sciences, Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia. FAU - Sukodiono AU - Sukodiono AUID- ORCID: 0000-0002-6349-7830 AD - Faculty of Medicine, Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia. FAU - Hakim, M Hanifuddin AU - Hakim MH AD - Industrial Engineering Department, Faculty of Engineering, Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia. FAU - Fitriyani, Vika Ramadhana AU - Fitriyani VR AUID- ORCID: 0009-0008-1562-1711 AD - Department of Nursing, Faculty of Health Sciences, Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia. AD - College of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Syarifurrahman, Islam AU - Syarifurrahman I AUID- ORCID: 0000-0001-6933-9836 AD - Department of Nursing, Faculty of Health Sciences, Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia. AD - College of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan. FAU - Choliq, Idham AU - Choliq I AUID- ORCID: 0000-0001-5831-4342 AD - Department of Nursing, Faculty of Health Sciences, Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia. AD - College of Nursing, Kaohsiung Medical University, Kaohsiung, Taiwan. AD - Research Center for Community Health and Artificial Intelligence (RECHAI), Universitas Muhammadiyah Surabaya, Surabaya, East Java, Indonesia. LA - eng GR - 128/C3/DT.05.00/PL/2025/Ministry of Higher Education, Science, and Technology, Indonesia/ PT - Journal Article PL - England TA - J Child Adolesc Psychiatr Nurs JT - Journal of child and adolescent psychiatric nursing : official publication of the Association of Child and Adolescent Psychiatric Nurses, Inc JID - 9431738 SB - IM MH - Humans MH - Adolescent MH - *Suicidal Ideation MH - Pilot Projects MH - Female MH - *Mobile Applications MH - Male MH - *Emotional Regulation MH - *Cognitive Behavioral Therapy/methods MH - *Mental Health MH - *Adolescent Behavior/psychology PMC - PMC13387718 OTO - NOTNLM OT - adolescents OT - application OT - mental health OT - pilot study OT - suicidal ideation COIS- The authors declare no conflicts of interest. EDAT- 2026/07/21 18:34 MHDA- 2026/07/21 18:35 PMCR- 2026/07/21 CRDT- 2026/07/21 15:32 PHST- 2026/06/12 00:00 [revised] PHST- 2026/01/13 00:00 [received] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/07/21 18:35 [medline] PHST- 2026/07/21 18:34 [pubmed] PHST- 2026/07/21 15:32 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - JCAP70064 [pii] AID - 10.1111/jcap.70064 [doi] PST - ppublish SO - J Child Adolesc Psychiatr Nurs. 2026 Aug;39(3):e70064. doi: 10.1111/jcap.70064. PMID- 42478984 OWN - NLM STAT- MEDLINE DCOM- 20260721 LR - 20260820 IS - 1221-9118 (Print) IS - 1221-9118 (Linking) VI - 121 IP - 3 DP - 2026 Jun TI - Anatomical and Molecular Insights into Sarcopenia in Liver Cirrhosis: A CT-Based and Biomarker Case-Control Study. PG - 309-320 LID - 8 [pii] LID - 10.21614/chirurgia.3325 [doi] AB - Background: Sarcopenia is a common complication and an important negative prognostic factor in patients with liver cirrhosis, being associated with reduced muscle mass and function, as well as increased mortality. Although computed tomography (CT) is considered the gold standard for assessing muscle mass, there is growing interest in identifying serum biomarkers that may facilitate the early diagnosis and monitoring of disease progression. The aim of this study was to evaluate the diagnostic value of osteonectin, the C-terminal agrin fragment (CAF), the N-terminal propeptide of type III procollagen (P3NP), and myostatin in patients with liver cirrhosis and sarcopenia, in correlation with CT-derived imaging parameters. Materials and Methods: A prospective observational caseacontrol study was conducted, including 60 participants: 30 patients with liver cirrhosis (with or without hepatocellular carcinoma) and sarcopenia, and 30 healthy control subjects. Sarcopenia was diagnosed according to the European Working Group on Sarcopenia in Older People 2 (EWGSOP2) criteria, using the skeletal muscle index (SMI) and psoas muscle index (PMI) measured by computed tomography. Serum concentrations of osteonectin, CAF, P3NP, and myostatin were determined using enzyme-linked immunosorbent assay (ELISA). Statistical analyses included parametric and non-parametric tests, as well as Pearson correlation analysis. Results: Patients with liver cirrhosis and sarcopenia exhibited significantly higher serum levels of osteonectin, CAF, P3NP, and myostatin compared with healthy controls (p 0.001 for all comparisons). The skeletal muscle index was significantly lower in cirrhotic patients, confirming the presence of muscle wasting. Correlation analysis demonstrated positive associations between osteonectin and CAF (r = 0.441, p 0.001), osteonectin and P3NP (r = 0.313, p = 0.016), osteonectin and myostatin (r = 0.444, p 0.001), as well as a strong correlation between CAF and myostatin (r = 0.882, p 0.001). No significant associations were observed between biomarker levels and viral etiology or ChildaPugh class. Conclusions: Simultaneous assessment of osteonectin, CAF, P3NP, and myostatin, combined with computed tomography-based imaging evaluation, may improve the diagnosis of sarcopenia associated with liver cirrhosis and facilitate the early identification of patients at increased risk of muscle deterioration. Larger multicenter prospective studies are warranted to validate the clinical utility of these biomarkers in routine medical practice. CI - Celsius. FAU - Gherghescu, Costel-George AU - Gherghescu CG FAU - Baz, Radu Andrei AU - Baz RA FAU - Dina, Constantin AU - Dina C FAU - Dumitru, Andrei AU - Dumitru A FAU - Cozaru, Georgeta Camelia AU - Cozaru GC FAU - Manea, Mihaela AU - Manea M FAU - Popescu, Ioana AU - Popescu I FAU - Grigorescu, Ana-Maria AU - Grigorescu AM FAU - Popescu, Stere AU - Popescu S FAU - Dumitru, Eugen AU - Dumitru E LA - eng PT - Journal Article PT - Observational Study PL - Romania TA - Chirurgia (Bucur) JT - Chirurgia (Bucharest, Romania : 1990) JID - 9213031 RN - 0 (Biomarkers) RN - 0 (Procollagen) RN - 0 (Osteonectin) RN - 0 (procollagen Type III-N-terminal peptide) RN - 0 (Myostatin) RN - 0 (Peptide Fragments) SB - IM MH - Humans MH - *Sarcopenia/blood/etiology/diagnosis/diagnostic imaging MH - Biomarkers/blood MH - Female MH - Male MH - *Liver Cirrhosis/complications/blood MH - Case-Control Studies MH - Prospective Studies MH - Procollagen/blood MH - *Tomography, X-Ray Computed MH - Osteonectin/blood MH - Middle Aged MH - Aged MH - *Myostatin/blood MH - Predictive Value of Tests MH - *Peptide Fragments/blood MH - Prognosis MH - Enzyme-Linked Immunosorbent Assay MH - Sensitivity and Specificity MH - Disease Progression OTO - NOTNLM OT - C-terminalagrinfragment OT - P3NP OT - biomarkers OT - computedtomography OT - fibrosis OT - livercirrhosis OT - musclewasting OT - myostatin OT - osteonectin OT - sarcopenia EDAT- 2026/07/21 12:35 MHDA- 2026/07/21 12:36 CRDT- 2026/07/21 10:13 PHST- 2026/06/01 00:00 [accepted] PHST- 2026/07/21 12:36 [medline] PHST- 2026/07/21 12:35 [pubmed] PHST- 2026/07/21 10:13 [entrez] AID - 8 [pii] AID - 10.21614/chirurgia.3325 [doi] PST - ppublish SO - Chirurgia (Bucur). 2026 Jun;121(3):309-320. doi: 10.21614/chirurgia.3325. PMID- 42478861 OWN - NLM STAT- Publisher LR - 20260721 IS - 1945-7197 (Electronic) IS - 0021-972X (Linking) DP - 2026 Jul 21 TI - Temporal stability of cardiometabolic risk factors from the perspective of primordial disease prevention in children. LID - dgag285 [pii] LID - 10.1210/clinem/dgag285 [doi] AB - CONTEXT AND OBJECTIVE: Excess adiposity and circulating lipoprotein lipids in childhood are predictive of cardiometabolic disease in adulthood. We analysed temporal tracking for body mass and lipid biomarkers using population-based time-series to assess the statistical feasibility of primordial prediction and prevention. DESIGN AND PARTICIPANTS: Individuals born between 1962-1992 were included from four European local community cohorts. Serial measurements of weight, height, waist and lipoprotein lipids were analysed for 12,212 participants (ages 5-49 years, follow-ups 15-31 years depending on cohort). Longitudinal tracking was quantified by autocorrelation R2 over the same individuals between any two visits in the series; the weakening of R2(Deltat) with increasing follow-up time was modelled by exponential decay. RESULTS: Based on the decay model, we calculated autocorrelation for two surveys fifteen years apart as a simplified tracking indicator: R2(15) = 35.7% for body-mass index, R2(15) = 28.1% for waist-height ratio and R2(15) = 32.5% for low-density lipoprotein (LDL) cholesterol. Total and high-density lipoprotein cholesterol were comparable to LDL cholesterol. Triglycerides exhibited weak tracking. The detection rate (DR5) at 5% false positive rate (FPR) of children who were in the top risk decile as adults was DR5(15) = 38.9% for body mass index and DR5(15) = 30.9% for LDL cholesterol. CONCLUSIONS: Individualised biomarker screening at low FPR misclassifies the majority of children who will have high values as adults (low statistical feasibility). Biomarker tracking is more useful for guiding broad population-based primordial prevention programmes that can be extended to all children at risk without harm from false positives. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Endocrine Society. FAU - Makinen, Ville-Petteri AU - Makinen VP AUID- ORCID: 0000-0002-7262-2656 AD - Systems Epidemiology, Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland. AD - Biocenter Oulu, University of Oulu, Oulu, Finland. FAU - Kahonen, Mika AU - Kahonen M AD - Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland. AD - Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. FAU - Lehtimaki, Terho AU - Lehtimaki T AUID- ORCID: 0000-0002-2555-4427 AD - Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. AD - Department of Clinical Chemistry, Tampere University Hospital, Tampere, Finland. AD - Fimlab Laboratories, Pirkanmaa Hospital District, Finland. FAU - Hutri, Nina AU - Hutri N AD - Tampere Centre for Skills Training and Simulation, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. FAU - Ronnemaa, Tapani AU - Ronnemaa T AD - Department of Medicine, University of Turku, Turku, Finland. AD - Division of Medicine, Turku University Hospital, Turku, Finland. FAU - Viikari, Jorma AU - Viikari J AUID- ORCID: 0000-0001-6452-010X AD - Department of Medicine, University of Turku, Turku, Finland. AD - Division of Medicine, Turku University Hospital, Turku, Finland. FAU - Pahkala, Katja AU - Pahkala K AUID- ORCID: 0000-0001-9338-4397 AD - Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. AD - Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. AD - Paavo Nurmi Centre, Unit of Health and Physical Activity, University of Turku, Turku, Finland. FAU - Rovio, Suvi AU - Rovio S AUID- ORCID: 0000-0003-0911-7478 AD - Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. AD - Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. AD - Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland. FAU - Niinikoski, Harri AU - Niinikoski H AD - Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. AD - Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. AD - Department of Pediatrics and Adolescent Medicine, Turku University Hospital, University of Turku, Turku, Finland. AD - Institute of Biomedicine, University of Turku, Turku, Finland. FAU - Mykkanen, Juha AU - Mykkanen J AUID- ORCID: 0000-0001-9898-2660 AD - Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. AD - Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. FAU - Raitakari, Olli AU - Raitakari O AUID- ORCID: 0000-0001-9365-3702 AD - Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. AD - Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. AD - Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital. AD - InFLAMES Research Flagship, University of Turku, Turku, Finland. FAU - Ala-Korpela, Mika AU - Ala-Korpela M AUID- ORCID: 0000-0001-5905-1206 AD - Systems Epidemiology, Research Unit of Population Health, Faculty of Medicine, University of Oulu, Oulu, Finland. AD - Biocenter Oulu, University of Oulu, Oulu, Finland. AD - NMR Metabolomics Laboratory, School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland. LA - eng PT - Journal Article DEP - 20260721 PL - United States TA - J Clin Endocrinol Metab JT - The Journal of clinical endocrinology and metabolism JID - 0375362 SB - IM OTO - NOTNLM OT - cardiovascular risk OT - disease prevention OT - lipid tracking OT - longitudinal OT - obesity EDAT- 2026/07/21 12:35 MHDA- 2026/07/21 12:35 CRDT- 2026/07/21 09:22 PHST- 2026/04/15 00:00 [received] PHST- 2026/06/26 00:00 [revised] PHST- 2026/07/12 00:00 [accepted] PHST- 2026/07/21 12:35 [medline] PHST- 2026/07/21 12:35 [pubmed] PHST- 2026/07/21 09:22 [entrez] AID - 8739136 [pii] AID - 10.1210/clinem/dgag285 [doi] PST - aheadofprint SO - J Clin Endocrinol Metab. 2026 Jul 21:dgag285. doi: 10.1210/clinem/dgag285. PMID- 42477844 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260917 LR - 20260919 IS - 2662-2211 (Electronic) IS - 2662-2211 (Linking) VI - 7 IP - 1 DP - 2026 Jul 20 TI - A co-creation approach to selecting and adapting adolescent tobacco and air-pollution interventions and strategies for implementation in diverse countries: insights from FRESHAIR4Life. LID - 10.1186/s43058-026-01044-4 [doi] LID - 188 AB - BACKGROUND: Evidence-based interventions to reduce adolescents' exposure to tobacco and air pollution are rarely implemented in low- and middle-income countries, often because they lack contextual fit. The 'FRESHAIR4Life' project aimed to optimise implementation of contextually adapted, evidence-based interventions in Greece, Kyrgyzstan, Pakistan, Romania, and Uganda. Selecting appropriate interventions required deliberate, inclusive, and context-sensitive decision-making. This paper outlines the co-creation approach for selecting and adapting interventions, developing implementation strategies and addressing the challenges that arose. METHODS: Each country followed a four-step process. First, findings from local situational analyses were consolidated to identify barriers and facilitators across individual, community, and system levels and to map targets for change using the Theoretical Domains Framework. This was followed by a workshop with country-teams to identify key risk factors, target behaviours, relevant populations and settings, and to shortlist potential interventions from the FRESHAIR4Life palette alongside implementation strategies using option grids and ranking. A subsequent stakeholder workshop applied a Socio Technical Allocation of Resources informed approach to elicit perspectives on the interventions' value using qualitative (Conversation Cafe style discussions) and quantitative methods (ratings of need, importance, likely reach, feasibility, and local adaptations required, fixed budget allocation exercises or ranking of options). Finally, selection meetings with country teams finalised intervention choices and implementation strategies, informed by stakeholder input. RESULTS: Countries chose to target the risk factors that were considered most prevalent and the biggest threat to adolescent health in their settings. Of the four countries addressing tobacco use, Pakistan, Greece, and Romania selected 'implementation intentions (If-Then approach)' for prevention, while Kyrgyzstan selected 'very brief advice plus behavioural counselling (VBA+)' for cessation. All three countries addressing air pollution, Pakistan, Uganda and Kyrgyzstan selected social media campaigns. Key challenges included: (1) establishing a sound basis for selection decisions, which was overcome by adopting a systematic, transparent and inclusive decision process (2) ethical and practical considerations for addressing tobacco/nicotine use within school-based prevention, tackled by adapting intervention to include offer of cessation support (3) limited evidence-based interventions targeting ambient air pollution, addressed by flexibly moving beyond the palette (4) the evolving nature of implementation strategies and (5) embedding interventions into routine practice, both addressed through flexibility and adaptation. CONCLUSION: This study shows that, across diverse country contexts, defensible intervention selection depends not only on which intervention is chosen, but on how choices are made and by whom. A transparent, stakeholder-owned co-creation process, involving the target audience of adolescents, helped country teams navigate trade-offs between evidence, local burden, feasibility, fit with routine practice, and ethical obligations, while exposing important evidence gaps for individual- and community-level ambient air-pollution interventions in LMICs. CI - (c) 2026. The Author(s). FAU - Abhyankar, Purva AU - Abhyankar P AUID- ORCID: 0000-0002-0779-6588 AD - Usher Institute, University of Edinburgh, 5‒7 Little France Road, Edinburgh BioQuarter ‒ Gate 3, Edinburgh, UK. pabhyank@ed.ac.uk. FAU - Lepe, Alexander AU - Lepe A AD - Global Health Unit, Department of Health Sciences, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. AD - Socio-Economic Panel, German Institute for Economic Research, Berlin, Germany. FAU - van der Schans, Jurjen AU - van der Schans J AD - Global Health Unit, Department of Health Sciences, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. FAU - van den Brand, Floor A AU - van den Brand FA AD - Department of Family Medicine (CAPHRI), Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. FAU - Siddiqui, Faraz AU - Siddiqui F AD - Department of Health Sciences, University of York, York, UK. FAU - Saeed, Saima AU - Saeed S AD - Indus Hospital and Health Network, Karachi, Pakistan. FAU - Akhter, Javeria AU - Akhter J AD - Indus Hospital and Health Network, Karachi, Pakistan. FAU - Khan, Amina AU - Khan A AD - The Initiative, Islamabad, Pakistan. FAU - Kamran Baba, Mian Ali AU - Kamran Baba MA AD - The Initiative, Islamabad, Pakistan. FAU - Tsiligianni, Ioanna AU - Tsiligianni I AD - Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. FAU - Bouloukaki, Izolde AU - Bouloukaki I AD - Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. FAU - Christodoulakis, Antonios AU - Christodoulakis A AD - Department of Social Medicine, Faculty of Medicine, University of Crete, Heraklion, Greece. FAU - Katagira, Winceslaus AU - Katagira W AD - College of Health Sciences, Makerere University Lung Institute, Makerere University, Kampala, Uganda. FAU - Kirenga, Bruce AU - Kirenga B AD - College of Health Sciences, Makerere University Lung Institute, Makerere University, Kampala, Uganda. FAU - Isar, Cristina AU - Isar C AD - Centrul National de Studii pentru Medicina Familiei (CNSMF RespiRO), Bucharest, Romania. FAU - Antohe, Adriana AU - Antohe A AD - Centrul National de Studii pentru Medicina Familiei (CNSMF RespiRO), Bucharest, Romania. FAU - Lupu, Anca AU - Lupu A AD - Centrul National de Studii pentru Medicina Familiei (CNSMF RespiRO), Bucharest, Romania. FAU - Neculau, Andrea AU - Neculau A AD - Universitatea Transilvania, Brasov, Romania. FAU - Sooronbaev, Talant AU - Sooronbaev T AD - Department of Pulmonology and Allergology, National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov, Bishkek, Kyrgyzstan. FAU - Mirzalieva, Gulzada AU - Mirzalieva G AD - Department of Pulmonology and Allergology, National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov, Bishkek, Kyrgyzstan. FAU - Taalaibekova, Aijan AU - Taalaibekova A AD - Department of Pulmonology and Allergology, National Center of Cardiology and Internal Medicine named after academician M.Mirrakhimov, Bishkek, Kyrgyzstan. FAU - van der Kleij, Rianne AU - van der Kleij R AD - Leiden University Medical Center, Public Health & Primary Care, Albinusdreef 2, Leiden, 2333 ZA, The Netherlands. FAU - Arvind, D K AU - Arvind DK AD - Centre for Speckled Computing, School of Informatics, University of Edinburgh, Edinburgh, UK. FAU - Williams, Sian AU - Williams S AD - International Primary Care Respiratory Group (IPCRG), Edinburgh, UK. FAU - Carvalho, Luis AU - Carvalho L AD - International Primary Care Respiratory Group (IPCRG), Edinburgh, UK. FAU - Pinnock, Hilary AU - Pinnock H AD - Usher Institute, University of Edinburgh, 5‒7 Little France Road, Edinburgh BioQuarter ‒ Gate 3, Edinburgh, UK. LA - eng GR - 101095461/HORIZON EUROPE European Research Council/ PT - Journal Article DEP - 20260720 PL - England TA - Implement Sci Commun JT - Implementation science communications JID - 101764360 PMC - PMC13584592 OTO - NOTNLM OT - Adaptation OT - Air pollution OT - Co-creation OT - Implementation research OT - Intervention selection OT - NCD prevention OT - Nicotine use OT - Stakeholder involvement OT - Tobacco use COIS- Declarations. Ethics approval and consent to participate: The research was conducted according to the ethical standards as outlined in the Declaration of Helsinki. Ethical approvals for all project activities were granted from the research ethics committees in all included countries. Kyrgyzstan: Ethical committee of the National Center of Cardiology and Internal Medicine named after academician capital EM, Cyrillic. Mismall pe, Cyrillicakhimov (NCCIM) (October 2023). Pakistan: National Institutes of Health, Health Research Institute, National Bioethics Committee For Research (NBC-R) (December 2023, January 2025). Greece: Ethics and Research Ethics Committee of University of Crete (February 2023). Romania: The Ethics Committee of Transilvania University of Brasov (CEU) (May 2024)Uganda: The Mulago Hospital Research and Ethics Committee (March 2024, July 2025). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/21 06:34 MHDA- 2026/07/21 06:35 PMCR- 2026/07/20 CRDT- 2026/07/21 00:07 PHST- 2025/11/06 00:00 [received] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/07/21 06:35 [medline] PHST- 2026/07/21 06:34 [pubmed] PHST- 2026/07/21 00:07 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - 10.1186/s43058-026-01044-4 [pii] AID - 1044 [pii] AID - 10.1186/s43058-026-01044-4 [doi] PST - epublish SO - Implement Sci Commun. 2026 Jul 20;7(1):188. doi: 10.1186/s43058-026-01044-4. PMID- 42477665 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261017 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jul 21 TI - Potassium intake assessed by dietary recall and urinary excretion in young South African adults: findings from the African-PREDICT study. LID - 10.1186/s12889-026-28605-5 [doi] LID - 2973 AB - BACKGROUND: South Africa has strong public health initiatives targeting salt reduction, yet population-level evidence and strategies regarding potassium intake remain limited. This gap is important given the role of potassium in mitigating sodium-related increases in blood pressure and cardiovascular disease risk. This study assessed potassium intake using dietary and urinary measures in young adults from the African-PREDICT study. METHODS: Potassium intake was estimated using three 24-hour dietary recalls and a single 24-hour urine collection per participant. Agreement between methods was evaluated using Bland-Altman analysis. RESULTS: Median potassium intake was 1911 mg/day from dietary assessment and 1683 mg/day from urinary analysis, both well below the recommended 3510 mg/day level, which is linked to sodium counterbalance and reduced cardiovascular risk. Over 90% of participants failed to meet the recommended intake across methods. Black participants and individuals of low socioeconomic status (SES) had substantially lower potassium intakes than their counterparts. Bland-Altman analysis demonstrated limited individual-level agreement (with a 95% limit-of-agreement span of approximately 5,600 mg/day), with dietary potassium intake marginally higher than urinary excretion (mean difference = 61 mg/day; p = 0.19), reflecting expected physiological potassium handling. In adjusted regression analyses, dietary potassium was inversely associated with diastolic blood pressure, while both urinary potassium and the sodium-to-potassium ratio showed no significant associations. CONCLUSION: Both methods show that potassium intake is low among young adults in South Africa, particularly among Black and low-SES groups, highlighting the need for population-level strategies to increase potassium consumption, particularly in vulnerable groups. The sodium-to-potassium ratio was associated with blood pressure only in the unadjusted model, whereas dietary potassium was associated with diastolic blood pressure in the adjusted model. Dietary assessment may be appropriate for population-level estimation of potassium intake, but its limited agreement with urinary potassium excretion at the individual level, particularly at higher intakes, may limit its utility for individual assessment. CI - (c) 2026. The Author(s). FAU - Shivambu, Arole AU - Shivambu A AD - Centre of Excellence for Nutrition, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa. shivambuarole@gmail.com. AD - Centre of Excellence for Nutrition (CEN), North-West University, 11 Hoffman Street, Potchefstroom, 2531, South Africa. shivambuarole@gmail.com. FAU - Chiromba, Antony K AU - Chiromba AK AD - Centre of Excellence for Nutrition, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa. FAU - van Zyl, Tertia AU - van Zyl T AD - Centre of Excellence for Nutrition, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa. AD - SAMRC/NWU Extramural Unit for Hypertension and Cardiovascular Disease, Faculty of Health Sciences, North-West University, Potchefstroom, South Africa. LA - eng PT - Journal Article DEP - 20260721 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Potassium, Dietary) SB - IM MH - Humans MH - South Africa MH - Female MH - Male MH - *Potassium, Dietary/urine/administration & dosage MH - Young Adult MH - Adult MH - *Mental Recall MH - Adolescent MH - *Diet/statistics & numerical data PMC - PMC13670738 OTO - NOTNLM OT - Blood pressure OT - Dietary potassium OT - Potassium intake OT - Urinary potassium OT - Young adults COIS- Declarations. Ethics approval and consent to participate: Ethical approval of the present study and the African-PREDICT were obtained from the North-West University Health Research Ethics Committee, reference numbers NWU-00136-22-A1 and NWU-00001-12-A1. Gatekeeper permissions were obtained from the National Department, and the North-West Provincial Department of Health. All participants provided written informed consent before data collection, and the study adhered to the updated principles of the Declaration of Helsinki. Competing interests: The authors declare no competing interests. Consent to participate: Not applicable. EDAT- 2026/07/21 00:35 MHDA- 2026/10/15 07:17 PMCR- 2026/07/21 CRDT- 2026/07/20 23:58 PHST- 2026/05/08 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/10/15 07:17 [medline] PHST- 2026/07/21 00:35 [pubmed] PHST- 2026/07/20 23:58 [entrez] PHST- 2026/07/21 00:00 [pmc-release] AID - 10.1186/s12889-026-28605-5 [pii] AID - 28605 [pii] AID - 10.1186/s12889-026-28605-5 [doi] PST - epublish SO - BMC Public Health. 2026 Jul 21;26(1):2973. doi: 10.1186/s12889-026-28605-5. PMID- 42477150 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261008 IS - 1432-5241 (Electronic) IS - 0364-216X (Linking) VI - 50 IP - 18 DP - 2026 Sep TI - Labia Majoraplasty: Deep Contouring with a Multivector Modification. PG - 7688-7694 LID - 10.1007/s00266-026-06149-8 [doi] AB - BACKGROUND: Procedures addressing the external genitalia, particularly labia minora, have become increasingly popular in aesthetic surgery. However, the labia majora is often overlooked despite its essential contribution to the overall genital harmony. METHODS: This study presents a multivector modification technique for labia majoraplasty aimed at restoring a youthful, smooth contour. Twenty-four patients presenting with sagging, wrinkling, and loss of adipose volume in the labia majora were included. A longitudinal incision along the interlabial sulcus and a transverse incision along the anogenital junction were combined. Deep tissue plication with delayed-absorbable sutures was performed for contouring before skin trimming and layered closure. RESULTS: Patient age ranged from 39 to 58 years, and 12 patients (50%) were active smokers. The median operative time was 55 minutes. No intraoperative or postoperative complications were observed during the follow-up period. Mild postoperative edema resolved spontaneously within 4 weeks. At follow-up, patients reported subjective improvement in aesthetic appearance and functional comfort, while preserved sensation and well-concealed scars were noted clinically. CONCLUSIONS: The described multivector labia majoraplasty technique appears to be a feasible approach for addressing labia majora ptosis and contour deformity by combining multidirectional skin excision with deep tissue support. Early outcomes in this preliminary case series were encouraging; however, larger comparative studies with validated outcome measures and longer follow-up are required to confirm long-term efficacy and durability. LEVEL OF EVIDENCE IV: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266. CI - (c) 2026. Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery. FAU - Kurt, Aylin AU - Kurt A AD - Private Practice of Plastic, Reconstructive and Aesthetic Surgery, Istanbul, Turkey. FAU - Ozturk, Sabri AU - Ozturk S AUID- ORCID: 0000-0001-6511-9609 AD - Department of Plastic, Reconstructive and Aesthetic Surgery, Bagcilar Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. md.sabriozturk@gmail.com. LA - eng PT - Journal Article DEP - 20260720 PL - United States TA - Aesthetic Plast Surg JT - Aesthetic plastic surgery JID - 7701756 SB - IM MH - Humans MH - Female MH - Adult MH - Middle Aged MH - Treatment Outcome MH - Esthetics MH - *Plastic Surgery Procedures/methods MH - *Vulva/surgery MH - Patient Satisfaction/statistics & numerical data MH - Cohort Studies MH - Follow-Up Studies MH - Risk Assessment MH - Suture Techniques OTO - NOTNLM OT - Genital rejuvenation OT - Labia majora reduction OT - Labia majoraplasty OT - Labiopexy COIS- Declarations. Conflict of interest: The authors have no financial interest to disclose in relation to the content of this article. Ethical Approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed Consent: Written informed consents of analysis and publication of personal data were obtained from all patients. EDAT- 2026/07/21 00:35 MHDA- 2026/10/08 05:31 CRDT- 2026/07/20 23:24 PHST- 2025/11/02 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/10/08 05:31 [medline] PHST- 2026/07/21 00:35 [pubmed] PHST- 2026/07/20 23:24 [entrez] AID - 10.1007/s00266-026-06149-8 [pii] AID - 10.1007/s00266-026-06149-8 [doi] PST - ppublish SO - Aesthetic Plast Surg. 2026 Sep;50(18):7688-7694. doi: 10.1007/s00266-026-06149-8. Epub 2026 Jul 20. PMID- 42475851 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260907 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 90 DP - 2026 Sep-Oct TI - Assessment of malnutrition in hospitalized children: Comparison of STAMP, PYMS and STRONG-Kids screening tools. PG - 618-626 LID - S0882-5963(26)00327-1 [pii] LID - 10.1016/j.pedn.2026.07.025 [doi] AB - AIM: Early identification of malnutrition risk in hospitalized children is essential for timely nutritional intervention. This study aims diagnostic performance of three pediatric malnutrition screening tools validated in Turkish: STAMP, PYMS, and STRONG-Kids. METHODS: In this cross-sectional study, 148 hospitalized children were included. Nutritional risk was evaluated using STAMP, PYMS, and STRONG-Kids screening tools. Anthropometric measurements were performed, and height-for-age, Body Mass Index (BMI)-for-age, and Middle Upper Arm Circumference (MUAC)-for-age z-scores were calculated. The sensitivity and specificity of each tool were assessed in identifying chronic and acute malnutrition. Receiver operating characteristic (ROC) curve analysis was used to assess the discriminative ability of the screening tools. RESULTS: Chronic malnutrition was identified in 12.8% of patients and acute malnutrition in 15.5%. STAMP and STRONG-Kids showed the highest sensitivity for detecting chronic malnutrition (84.2% and 84.3%), while PYMS had the highest specificity. STRONG-Kids demonstrated the greatest sensitivity for acute malnutrition and low MUAC z-scores (100.0%). ROC analysis showed that PYMS had the highest Area Under the Curve (AUC) for acute malnutrition, whereas STRONG-Kids had the highest AUC for chronic malnutrition, although all tools demonstrated limited discriminative ability for chronic malnutrition. CONCLUSION: STAMP and STRONG-Kids were more sensitive in detecting malnutrition risk, whereas PYMS showed higher specificity. Tool performance varied according to anthropometric indicators. IMPLICATIONS TO PRACTICE: In clinical practice, selecting the screening tool according to the targeted malnutrition type and available anthropometric indicators may improve early detection and allow more effective prioritization of nutritional interventions in hospitalized children. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Mutlu, Elif AU - Mutlu E AD - Ankara University, Graduate School of Health Sciences, Department of Nutrition and Dietetics, Ankara, Turkiye. Electronic address: elifmutlu@hacettepe.edu.tr. FAU - Kokturk, Seda Nur AU - Kokturk SN AD - Bayburt University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Bayburt, Turkiye. Electronic address: sedanurkokturk@bayburt.edu.tr. FAU - Ersoy Soke, Nursena AU - Ersoy Soke N AD - Ankara University, Graduate School of Health Sciences, Department of Nutrition and Dietetics, Ankara, Turkiye. FAU - Yardimci, Hulya AU - Yardimci H AD - Ankara University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Ankara, Turkiye. Electronic address: yildirimh@ankara.edu.tr. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260720 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Male MH - Child, Preschool MH - *Mass Screening/methods MH - Turkey MH - *Nutrition Assessment MH - *Child, Hospitalized MH - Sensitivity and Specificity MH - Child MH - *Child Nutrition Disorders/diagnosis/epidemiology MH - Infant MH - ROC Curve MH - Risk Assessment MH - *Malnutrition/diagnosis MH - Anthropometry MH - Nutritional Status MH - Body Mass Index OTO - NOTNLM OT - Child OT - Malnutrition OT - Nutrition assessment OT - Nutritional status COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/21 00:35 MHDA- 2026/09/07 23:34 CRDT- 2026/07/20 18:03 PHST- 2026/01/07 00:00 [received] PHST- 2026/07/13 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/09/07 23:34 [medline] PHST- 2026/07/21 00:35 [pubmed] PHST- 2026/07/20 18:03 [entrez] AID - S0882-5963(26)00327-1 [pii] AID - 10.1016/j.pedn.2026.07.025 [doi] PST - ppublish SO - J Pediatr Nurs. 2026 Sep-Oct;90:618-626. doi: 10.1016/j.pedn.2026.07.025. Epub 2026 Jul 20. PMID- 42475675 OWN - NLM STAT- MEDLINE DCOM- 20260720 LR - 20260813 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 28 DP - 2026 Jul 20 TI - Mobile App Use and Pregnancy Health Literacy: Cross-Sectional Study Using Bayesian Network Analysis. PG - e85403 LID - 10.2196/85403 [doi] LID - e85403 AB - BACKGROUND: Health literacy is crucial for pregnancy outcomes; yet, 15%-44% of pregnant women have low health literacy, negatively affecting maternal and fetal health. While pregnancy apps are increasingly used to support it, the psychological mechanisms through which they influence behavior remain unclear. Understanding these mechanisms is essential for designing effective interventions. Cognitive load theory (CLT) and the integrated model of cognitive-affective learning with media (ICALM) provide theoretical frameworks for understanding these digital interventions in pregnancy's emotionally intense context. OBJECTIVE: This study aimed to understand the psychological and social-cognitive pathways through which engagement with pregnancy apps may enhance health literacy and behaviors. METHODS: This cross-sectional survey study included 998 pregnant and early postpartum women aged 18-45 years from the United States and analyzed the data using Bayesian Network (BN) modeling informed by CLT and ICALM. Participants were stratified into Pregnancy+ (Royal Philips) users (n=362), other pregnancy app users (n=507), and nonapp users (n=129). We measured digital engagement, emotions, health literacy levels, support levels and sources, and health behaviors, including physical activity, nutrition, and stress management. The BN model underwent systematic refinement through bootstrap resampling (n=1000) to evaluate arc strength, followed by k-fold cross-validation (k=5) to assess model generalizability and predictive performance. RESULTS: In our study, pregnancy apps improve health literacy or behaviors, but not through direct pathways. Instead, they work through two indirect psychological pathways: (1) digital engagement related to positive emotions, which in turn is related to health literacy and stress management, and (2) digital engagement strengthened support networks, which in turn are related to health literacy. No direct pathways from digital engagement to health literacy or behaviors were retained. Pregnancy+ users demonstrated stronger adherence to these pathways compared with other app users and nonusers, by demonstrating more joyfulness (5.1 vs 4.7; P=.046), elevated support levels (4.1 vs 3.9; P=.03), and higher critical health literacy scores (8.4 vs 8.2 vs 7.7; P<.001). Pregnancy+ users also showed higher engagement frequencies (P<.001) and more frequently cited pregnancy apps as valuable information sources (78% vs 68%, P=.01) compared with users of other pregnancy apps. CONCLUSIONS: This study reveals that pregnancy apps may enhance health literacy by fostering positive emotions and strengthening support networks. This finding challenges assumptions about digital health interventions and demonstrates that apps function as psychological support systems rather than mere information sources. The findings validate CLT and ICALM within pregnancy contexts, showing that emotionally supportive apps reduce irrelevant emotional processing that consumes cognitive capacity, thereby enhancing information retention. For practice, app developers should prioritize emotional support and social connection over content volume, while health care providers should recommend apps that enhance emotional well-being. This study demonstrates BN's value for revealing complex psychological relationships in digital health contexts. CI - (c)Hanne A A Spelt, Renee A Otte, Ad J M Denissen, Shihan Wang, Erin E O'Connor, Robin Neuhaus, Lucie Duracher. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 20.07.2026. FAU - Spelt, Hanne A A AU - Spelt HAA AUID- ORCID: 0000-0002-5304-4109 AD - Research & Development, Philips Mother & Child Care and Women's Health, Eindhoven, The Netherlands. FAU - Otte, Renee A AU - Otte RA AUID- ORCID: 0000-0001-7939-6199 AD - Research & Development, Philips Mother & Child Care and Women's Health, Eindhoven, The Netherlands. FAU - Denissen, Ad J M AU - Denissen AJM AUID- ORCID: 0000-0003-4244-8850 AD - Innovation & Development and AI Solutions, Philips Data Science & AI Engineering, Eindhoven, The Netherlands. FAU - Wang, Shihan AU - Wang S AUID- ORCID: 0000-0001-5971-7522 AD - Department of Information and Computing Sciences, Utrecht University, Utrecht, The Netherlands. FAU - O'Connor, Erin E AU - O'Connor EE AUID- ORCID: 0009-0005-3361-1080 AD - Nested Institute for Families, New York, NY, United States. AD - Teaching and Learning, New York University, New York, NY, United States. FAU - Neuhaus, Robin AU - Neuhaus R AUID- ORCID: 0000-0002-6975-8712 AD - Nested Institute for Families, New York, NY, United States. AD - Teaching and Learning, New York University, New York, NY, United States. FAU - Duracher, Lucie AU - Duracher L AUID- ORCID: 0009-0001-5391-0425 AD - Research & Development, Philips Mother & Child Care and Women's Health, Eindhoven, The Netherlands. LA - eng PT - Journal Article DEP - 20260720 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 SB - IM MH - Female MH - Humans MH - Pregnancy MH - *Health Literacy MH - *Mobile Applications/statistics & numerical data MH - Cross-Sectional Studies MH - Bayes Theorem MH - Adult MH - Adolescent MH - Young Adult MH - Middle Aged MH - Digital Health PMC - PMC13434253 OTO - NOTNLM OT - Bayesian networks OT - digital lifestyle interventions OT - health literacy OT - mHealth OT - mobile apps OT - pregnancy OT - probabilistic networks OT - women's health COIS- Conflicts of Interest: HAAS, RAO, AJMD, and LD are employed by Royal Philips, which also owns Pregnancy+. EDAT- 2026/07/20 18:35 MHDA- 2026/07/20 18:36 PMCR- 2026/07/20 CRDT- 2026/07/20 16:53 PHST- 2025/10/07 00:00 [received] PHST- 2026/04/10 00:00 [accepted] PHST- 2026/07/20 18:36 [medline] PHST- 2026/07/20 18:35 [pubmed] PHST- 2026/07/20 16:53 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - v28i1e85403 [pii] AID - 10.2196/85403 [doi] PST - epublish SO - J Med Internet Res. 2026 Jul 20;28:e85403. doi: 10.2196/85403. PMID- 42474956 OWN - NLM STAT- Publisher LR - 20260720 IS - 1573-3432 (Electronic) IS - 0162-3257 (Linking) DP - 2026 Jul 20 TI - Dropout From Exercise Interventions in Autistic Youth: A Systematic Review and Meta-analysis. LID - 10.1007/s10803-026-07447-5 [doi] AB - PURPOSE: Exercise has multiple physical and mental health benefits for autistic youth. Dropouts from randomized controlled trials (RCTs) pose a threat to the validity of the evidence, with dropout rates varying across studies. We conducted a meta-analysis to investigate the prevalence and predictors of dropout rates among autistic youth participating in exercise RCTs. METHODS: Two authors searched major electronic databases up to 04/2025. We included RCTs of exercise interventions in autistic children and adolescents that reported dropout rates. A random effects meta-analysis, calculating the dropout prevalence in exercise group and a comparative meta-analysis comparing dropout in exercise versus control groups were conducted. Meta-regressions and subgroup analyses were conducted to explore dropout moderators. RESULTS: 21 RCT's involving 25 exercise interventions (n = 565, mean age 5.1 to 12.8 years; 81.2% males) were included. The trim-and-fill-adjusted prevalence of dropout across all studies was 24.4% (95%CI = 18.1% to 32.1%). Significant differences in dropout rates were found for the type of exercise intervention (p < 0.001), intensity (p = 0.003), and overall intervention duration (p = 0.032). Dropout was similar in exercise versus control conditions (OR = 1.0, 95%CI = 0.97 to 1.0, p = 0.90, I(2) = 0%). CONCLUSIONS: Exercise is well tolerated by autistic children and m-adolescents and drop out in RCT's is comparable to control conditions. Thus, exercise is a feasible treatment and dropout rates decrease when the intervention is aerobic exercise, with either low or high intensity and when total intervention duration is shorter. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Van Damme, Tine AU - Van Damme T AUID- ORCID: 0000-0002-8197-6704 AD - Department of Rehabilitation Sciences, KU Leuven, Herestraat 49 box 1510, Leuven, 3000, Belgium. Tine.vandamme@kuleuven.be. AD - University Psychiatric Center KU Leuven, Leuven, Belgium. Tine.vandamme@kuleuven.be. FAU - Zwahlen, Isabel AU - Zwahlen I AUID- ORCID: 0009-0001-0865-7168 AD - Department of Rehabilitation Sciences, KU Leuven, Herestraat 49 box 1510, Leuven, 3000, Belgium. FAU - de Oliveira, Jenifer AU - de Oliveira J AUID- ORCID: 0000-0001-8616-6594 AD - Department of Sports Methods and Techniques, Federal University of Santa Maria, Santa Maria, Brazil. FAU - Meers, Esther AU - Meers E AUID- ORCID: 0009-0004-0626-6317 AD - Department of Rehabilitation Sciences, KU Leuven, Herestraat 49 box 1510, Leuven, 3000, Belgium. FAU - Schuch, Felipe Barreto AU - Schuch FB AUID- ORCID: 0000-0002-5190-4515 AD - Food and Mood Centre, Institute for Mental and Physical Health and Clinical Translation (IMPACT), Deakin University, Geelong, Australia. AD - Institute for Physical Activity and Nutrition (IPAN), Deakin University, Geelong, Australia. AD - Department of Sports Methods and Techniques, Federal University of Santa Maria, Santa Maria, Brazil. AD - Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. AD - Faculty of Health Sciences, Universidad Autonoma de Chile, Providencia, Chile. FAU - Vancampfort, Davy AU - Vancampfort D AUID- ORCID: 0000-0002-4592-8625 AD - Department of Rehabilitation Sciences, KU Leuven, Herestraat 49 box 1510, Leuven, 3000, Belgium. AD - University Psychiatric Center KU Leuven, Leuven, Belgium. AD - Leuven Brain Institute, Leuven, Belgium. LA - eng PT - Journal Article DEP - 20260720 PL - United States TA - J Autism Dev Disord JT - Journal of autism and developmental disorders JID - 7904301 SB - IM OTO - NOTNLM OT - Autism OT - Dropout, exercise OT - Physical activity COIS- Declarations. Conflict of interest: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/07/20 12:40 MHDA- 2026/07/20 12:40 CRDT- 2026/07/20 11:19 PHST- 2025/10/09 00:00 [received] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/07/20 12:40 [medline] PHST- 2026/07/20 12:40 [pubmed] PHST- 2026/07/20 11:19 [entrez] AID - 10.1007/s10803-026-07447-5 [pii] AID - 10.1007/s10803-026-07447-5 [doi] PST - aheadofprint SO - J Autism Dev Disord. 2026 Jul 20. doi: 10.1007/s10803-026-07447-5. PMID- 42474673 OWN - NLM STAT- Publisher LR - 20260720 IS - 1573-2584 (Electronic) IS - 0301-1623 (Linking) DP - 2026 Jul 20 TI - Clinical outcomes of thulium fiber laser versus holmium:YAG laser during pediatric retrograde intrarenal surgery: a multicenter cohort study. LID - 10.1007/s11255-026-05292-0 [doi] AB - OBJECTIVE: The thulium fiber laser (TFL) is a new-generation laser technology that has been increasingly used in endourology in recent years. However, data on the use of TFL in the treatment of pediatric kidney stones are limited. The aim of this study was to compare the efficacy and safety of thulium fiber laser (TFL) and Holmium: Yttrium Aluminum Garnet (Ho:YAG) laser in children undergoing retrograde intrarenal surgery (RIRS) for a solitary renal stone measuring 10-20 mm. MATERIALS AND METHODS: Pediatric patients (< 18 years) with a solitary renal stone measuring 10-20 mm who underwent RIRS at two tertiary referral centers between January 2020 and March 2026 were retrospectively reviewed. Patients were divided into two groups based on the laser technology used: Ho:YAG and TFL. Ho:YAG lithotripsy was predominantly performed using fragmentation strategy, whereas TFL was mainly used in dusting mode. The primary endpoint was the stone-free rate (SFR), as assessed by ultrasound at the third postoperative month. Secondary endpoints included operative time, fluoroscopy time, intraoperative stone retropulsion, the need for reintervention, length of hospital stay, and complications according to the Clavien-Dindo classification. RESULTS: A total of 74 patients were included in the study. Forty-eight patients were treated with Ho:YAG, and 26 with TFL. The groups were comparable in terms of age, sex, body mass index, stone size, stone density, and stone location. Operative time was significantly shorter in the TFL group than in the Ho:YAG group (64.0 +/- 28.35 vs. 80.0 +/- 30.17 min, p = 0.028). Intraoperative stone retropulsion occurred significantly less frequently in the TFL group (11.5% vs. 35.4%, p = 0.031). The 3-month stone-free rate was 92.3% in the TFL group and 85.4% in the Ho:YAG group, with no significant difference between the groups (p = 0.486). No significant differences were found between the groups in terms of fluoroscopy time, reintervention rate, and length of hospital stay. Complication rates were similar, and no Clavien-Dindo grade IV or V complications were observed in either group. CONCLUSION: These findings suggest that TFL may represent a safe and effective alternative to the Ho:YAG laser in pediatric RIRS. However, further prospective multicenter studies using standardized laser settings are warranted to validate these findings. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature B.V. FAU - Ozcift, Burak AU - Ozcift B AUID- ORCID: 0000-0001-8474-2308 AD - Department of Pediatric Urology, Health Sciences University, Izmir Dr. Behcet Uz Child Diseases and Surgery Training and Research Hospital, Ismet Kaptan Mh. Sezer Dogan Sok. No: 11 Konak, Izmir, Turkey. burakozcift@gmail.com. FAU - Micoogullari, Uygar AU - Micoogullari U AUID- ORCID: 0000-0003-4729-6104 AD - Department of Urology, Izmir Can Hospital, Izmir, Turkey. LA - eng PT - Journal Article DEP - 20260720 PL - Netherlands TA - Int Urol Nephrol JT - International urology and nephrology JID - 0262521 SB - IM OTO - NOTNLM OT - Flexible ureteroscopy OT - Holmium:YAG laser OT - Pediatric urolithiasis OT - Renal stone OT - Retrograde intrarenal surgery OT - Thulium fiber laser COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of Health Sciences University Tepecik Training and Research Hospital (No. 2022/12-27). EDAT- 2026/07/20 12:40 MHDA- 2026/07/20 12:40 CRDT- 2026/07/20 11:08 PHST- 2026/06/27 00:00 [received] PHST- 2026/07/15 00:00 [accepted] PHST- 2026/07/20 12:40 [medline] PHST- 2026/07/20 12:40 [pubmed] PHST- 2026/07/20 11:08 [entrez] AID - 10.1007/s11255-026-05292-0 [pii] AID - 10.1007/s11255-026-05292-0 [doi] PST - aheadofprint SO - Int Urol Nephrol. 2026 Jul 20. doi: 10.1007/s11255-026-05292-0. PMID- 42474402 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20260923 IS - 2212-2672 (Print) IS - 2212-2672 (Linking) VI - 126 IP - 10 DP - 2026 Oct TI - Understanding Postpartum Mothers' Perspectives of Chrononutrition Approaches: A Qualitative Study. PG - 156393 LID - S2212-2672(26)00108-5 [pii] LID - 10.1016/j.jand.2026.156393 [doi] AB - BACKGROUND: Postpartum weight retention (PPWR) is common and associated with poor health outcomes. Traditional weight management approaches have limited success postpartum. Due to infant-related sleep disruptions, late-night eating may be more common postpartum and contribute to PPWR. Chrononutrition interventions, which align energy intake with circadian rhythms in metabolism, demonstrate promise for weight loss in nonpostpartum populations and offer a novel approach to preventing PPWR. However, no studies have explored whether chrononutrition approaches may be acceptable postpartum, which is needed to inform which approaches may warrant subsequent testing. OBJECTIVE: To characterize perceived determinants of eating timing and understand the feasibility of following various chrononutrition approaches among postpartum mothers. DESIGN: A qualitative descriptive study using semistructured interviews to query participants about the following chrononutrition approaches, which they also ranked from most to least preferred: bedtime stopping rule (no energy intake within a certain number of hours of bedtime); king's breakfast, pauper's dinner (distributing kilocalories so intake is highest at breakfast and lowest at dinner), and time-restricted eating (shortening the daily eating window to /= 2, body mass index (BMI) >/= 24.0 kg/m(2), and concurrent endometriosis were significantly associated with recurrence (p < 0.05). Three factors were recognized as independent predictors of recurrence through multivariate logistic regression. The area under the receiver operating characteristic curve of the constructed nomogram model was 0.791 (95% confidence interval: 0.724-0.858). Decision curve analysis showed a good clinical net benefit, and calibration curves showed a high consistency between the predicted and actual recurrence probabilities. CONCLUSION: Patients with CUL who have risk factors require close monitoring for postoperative recurrence. The developed nomogram model exhibited good predictive performance, thereby offering a reference for treatment choice and recurrence prediction. CI - (c) 2026 Published by Elsevier B.V. FAU - Zhong, Yanling AU - Zhong Y AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, No. 18, Daoshan Road, Gulou District, Fuzhou 350001, China. FAU - Xu, Mu AU - Xu M AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, No. 18, Daoshan Road, Gulou District, Fuzhou 350001, China. FAU - Cai, Liangzhi AU - Cai L AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, No. 18, Daoshan Road, Gulou District, Fuzhou 350001, China. LA - eng PT - Journal Article DEP - 20260617 PL - Netherlands TA - Eur J Obstet Gynecol Reprod Biol X JT - European journal of obstetrics & gynecology and reproductive biology: X JID - 101750520 PMC - PMC13380213 OTO - NOTNLM OT - Cellular uterine leiomyoma OT - Myomectomy OT - Postoperative recurrence OT - Predictive model COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/19 06:41 MHDA- 2026/07/19 06:42 PMCR- 2026/06/17 CRDT- 2026/07/19 03:53 PHST- 2025/09/02 00:00 [received] PHST- 2026/05/24 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/07/19 06:42 [medline] PHST- 2026/07/19 06:41 [pubmed] PHST- 2026/07/19 03:53 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - S2590-1613(26)00026-8 [pii] AID - 100469 [pii] AID - 10.1016/j.eurox.2026.100469 [doi] PST - epublish SO - Eur J Obstet Gynecol Reprod Biol X. 2026 Jun 17;31:100469. doi: 10.1016/j.eurox.2026.100469. eCollection 2026 Sep. PMID- 42471634 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261017 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 18 TI - Associations of Haller index and manual depth measurement with clinical findings and pulmonary function in children with pectus excavatum: a retrospective cross-sectional study. LID - 10.1186/s12887-026-07308-1 [doi] LID - 1003 AB - BACKGROUND: Pectus excavatum (PE) is the most common congenital chest wall deformity. Its severity is usually assessed by chest computed tomography (CT) based indices such as the Haller index (HI) and correction index (CI). However, evidence supporting non-imaging anthropometric methods is limited. Manual depth measurement (MDM) is a simple, noninvasive bedside method that may offer clinical value. METHODS: This retrospective cross-sectional study included children diagnosed with pectus excavatum and followed at a tertiary center between 2017 and 2024. Demographics, pulmonary function tests (PFTs), symptoms, comorbidities, and echocardiographic data were analyzed. HI and CI were measured using chest CT scans. MDM values recorded during follow-up were retrieved from physical exam notes. RESULTS: A total of 127 patients were included, with a median age of 7.25 years (IQR, 7.05). Median HI was 2.70 (IQR, 0.56), median MDM was 2.00 cm (IQR, 1.35), and median CI was 16% (IQR, 6.7). MDM was significantly correlated with HI (p = 0.012). ROC analysis showed that MDM moderately but significantly discriminated severe deformity defined as HI> 2.5, with an optimal cut-off value of 1.75 cm. Respiratory symptoms and comorbidities were present in 39.4% and 38.6% of patients, respectively. Pulmonary function impairment was observed in 19% of patients, predominantly with a restrictive pattern. HI> 2.5 was associated with reduced forced vital capacity (FVC) and total lung capacity (TLC), whereas the association between MDM> 1.75 cm and TLC <80% weakened after adjustment for age. CONCLUSION: MDM is a practical bedside measurement that correlates with HI and involves no radiation exposure. An MDM threshold of 1.75 cm was associated with HI> 2.5 in the CT-evaluated subgroup and may support conservative follow-up when interpreted together with clinical and functional findings. This threshold should be considered exploratory and requires prospective validation. CI - (c) 2026. The Author(s). FAU - Yoruk, Begum AU - Yoruk B AUID- ORCID: 0000-0001-6599-9802 AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. FAU - Caglar, Yasemin Mocan AU - Caglar YM AUID- ORCID: 0000-0002-9609-478X AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. FAU - Ulgen, Ozge AU - Ulgen O AUID- ORCID: 0000-0002-9271-5446 AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. FAU - Oksay, Sinem Can AU - Oksay SC AUID- ORCID: 0000-0001-9801-3181 AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. FAU - Bilgin, Gulay AU - Bilgin G AUID- ORCID: 0000-0001-6207-3748 AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. FAU - Tortop, Deniz Mavi AU - Tortop DM AUID- ORCID: 0000-0002-9134-5658 AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. FAU - Girit, Saniye AU - Girit S AUID- ORCID: 0000-0001-7556-6568 AD - Division of Pediatric Pulmonology, Faculty of Medicine, Medeniyet University, Istanbul, Turkiye. saniye.girit@medeniyet.edu.tr. LA - eng PT - Journal Article DEP - 20260718 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Funnel Chest/physiopathology/diagnosis/diagnostic imaging MH - Cross-Sectional Studies MH - Retrospective Studies MH - Child MH - Female MH - Male MH - Respiratory Function Tests MH - Tomography, X-Ray Computed MH - Severity of Illness Index MH - Child, Preschool MH - Adolescent MH - *Anthropometry/methods PMC - PMC13670605 OTO - NOTNLM OT - anthropometric measurement OT - manual depth measurement OT - pectus excavatum OT - pediatric OT - pulmonary function test COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethics Committee of Kartal Kosuyolu Hospital on January 7, 2025 (Approval Number: 2025/01/1005). The study was conducted in accordance with the principles of the Declaration of Helsinki. Due to the retrospective design of the study, the requirement for informed consent, including parental or legal guardian consent for participants younger than 16 years of age, was waived by the ethics committee. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/19 04:00 MHDA- 2026/10/15 07:17 PMCR- 2026/07/18 CRDT- 2026/07/18 23:25 PHST- 2026/05/09 00:00 [received] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/10/15 07:17 [medline] PHST- 2026/07/19 04:00 [pubmed] PHST- 2026/07/18 23:25 [entrez] PHST- 2026/07/18 00:00 [pmc-release] AID - 10.1186/s12887-026-07308-1 [pii] AID - 7308 [pii] AID - 10.1186/s12887-026-07308-1 [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 18;26(1):1003. doi: 10.1186/s12887-026-07308-1. PMID- 42470661 OWN - NLM STAT- MEDLINE DCOM- 20260718 LR - 20260826 IS - 1532-7078 (Electronic) IS - 1525-0008 (Print) IS - 1532-7078 (Linking) VI - 31 IP - 4 DP - 2026 Jul-Aug TI - Brain Activity of Young Children in Bangladesh Is Associated With Biopsychosocial Conditions at the Individual-, Family-, and Household-Level. PG - e70108 LID - 10.1111/infa.70108 [doi] LID - e70108 AB - Adversities in early life compromise children's nurturing care and impact their development. This study explored the biopsychosocial conditions associated with electroencephalography (EEG)-based brain activity in children living in rural Bangladesh, a setting with high rates of malnutrition and suboptimal psychosocial stimulation. In a substudy of the Benefits and Risks of Iron Supplementation in Children (BRISC) study in Bangladesh, we recorded resting EEG brain activity in a random subsample of 440 children at 11 months and 594 children at 20 months of age. EEG band power measures were derived for delta, theta, alpha, and beta power bands. Validated tools were used to assess maternal depression, household food insecurity, and psychosocial stimulation. Children's anthropometry, venous hemoglobin and ferritin concentrations, and inflammation were also measured. Linear regression analyses were conducted to identify the concurrent and lagged biopsychosocial conditions associated with EEG-based brain activity. Growth, nutritional status, psychosocial stimulation, and household food security were associated with concurrent and lagged brain activity. The direction of association differed by EEG frequency band, but the majority of biopsychosocial conditions were positively associated with activity in the higher frequency bands and negatively with lower frequency bands. Our findings indicate that brain activity in children can be influenced by a range of biopsychosocial adversities. Children's nutrition, quality and quantity of psychosocial stimulation, and food security influence their current and later brain activity in this resource-limited setting in South Asia. TRIAL REGISTRATION: ACTRN12617000660381. CI - (c) 2026 The Author(s). Infancy published by Wiley Periodicals LLC on behalf of International Congress of Infant Studies. FAU - Larson, Leila M AU - Larson LM AUID- ORCID: 0000-0002-2570-7323 AD - Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA. FAU - Feuerriegel, Daniel AU - Feuerriegel D AUID- ORCID: 0000-0002-0357-1920 AD - Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia. FAU - Lall, Gitanjali AU - Lall G AD - Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, Columbia, South Carolina, USA. FAU - Imrul Hasan, Mohammed AU - Imrul Hasan M AD - Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. AD - Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia. FAU - Braat, Sabine AU - Braat S AD - Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia. AD - Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia. AD - Department of Infectious Diseases at the Peter Doherty Institute, The University of Melbourne, Melbourne, Victoria, Australia. FAU - Jin, Jerry AU - Jin J AD - Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia. AD - Department of Infectious Diseases at the Peter Doherty Institute, The University of Melbourne, Melbourne, Victoria, Australia. FAU - Biggs, Beverley-Ann AU - Biggs BA AD - Department of Infectious Diseases at the Peter Doherty Institute, The University of Melbourne, Melbourne, Victoria, Australia. AD - The Victorian Infectious Diseases Service, The Royal Melbourne Hospital, Melbourne, Victoria, Australia. FAU - Bode, Stefan AU - Bode S AD - Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia. AD - Division of Science, New York University Abu Dhabi, Abu Dhabi, UAE. FAU - Pasricha, Sant-Rayn AU - Pasricha SR AD - Population Health and Immunity Division, Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia. AD - Diagnostic Haematology, The Royal Melbourne Hospital, Melbourne, Victoria, Australia. AD - Diagnostic Haematology and Clinical Haematology, The Peter MacCallum Cancer Centre and The Royal Melbourne Hospital, Melbourne, Victoria, Australia. AD - Department of Medical Biology, The University of Melbourne, Melbourne, Victoria, Australia. FAU - Johnson, Katherine A AU - Johnson KA AUID- ORCID: 0000-0002-2029-163X AD - Melbourne School of Psychological Sciences, The University of Melbourne, Melbourne, Victoria, Australia. FAU - Hamadani, Jena D AU - Hamadani JD AD - Maternal and Child Health Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. LA - eng GR - GNT1103262/National Health and Medical Research Council/ GR - GNT1159151/National Health and Medical Research Council/ GR - GNT1158696/National Health and Medical Research Council/ GR - University of Melbourne/ PT - Journal Article PL - United States TA - Infancy JT - Infancy : the official journal of the International Society on Infant Studies JID - 100890607 SB - IM MH - Humans MH - Bangladesh MH - Female MH - Electroencephalography MH - Infant MH - Male MH - *Brain/physiology MH - Nutritional Status MH - Rural Population MH - *Child Development/physiology MH - Family Characteristics PMC - PMC13380311 COIS- The authors declare no conflicts of interest. EDAT- 2026/07/19 01:03 MHDA- 2026/07/19 01:04 PMCR- 2026/07/18 CRDT- 2026/07/18 13:43 PHST- 2026/05/29 00:00 [revised] PHST- 2025/07/31 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/19 01:04 [medline] PHST- 2026/07/19 01:03 [pubmed] PHST- 2026/07/18 13:43 [entrez] PHST- 2026/07/18 00:00 [pmc-release] AID - INFA70108 [pii] AID - 10.1111/infa.70108 [doi] PST - ppublish SO - Infancy. 2026 Jul-Aug;31(4):e70108. doi: 10.1111/infa.70108. PMID- 42470033 OWN - NLM STAT- MEDLINE DCOM- 20260718 LR - 20260903 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 29 DP - 2026 Jul 17 TI - Disproportionality analysis of sex-stratified adverse event signals in growth impairment: Insights from the FDA adverse event reporting system. PG - e49802 LID - 10.1097/MD.0000000000049802 [doi] LID - e49802 AB - This study aimed to examine sex-disaggregated adverse event signals associated with growth impairment in pediatric patients, utilizing data from the FDA adverse event reporting system, with a particular focus on growth hormone and related therapeutic agents. A disproportionality analysis was performed on FDA adverse event reporting system data spanning 2004 Q1 to 2025 Q1. The analysis encompassed 3281 growth impairment-related reports, disaggregated by gender, employing Reporting Odds Ratios (ROR) and proportional reporting ratios for signal detection, with temporal patterns assessed via Weibull distribution modeling. Significant sex-disaggregated disparities in safety signals were identified. Somatropin exhibited a stronger association with growth impairment in females (ROR 76.85, 95% CI 65.52-90.15) than in males (ROR 37.31, 95% CI 32.99-42.20). Deflazacort showed a male-exclusive signal (ROR 58.25, 95% CI 41.27-82.21), while imatinib displayed a higher risk in females (ROR 15.55, 95% CI 11.29-21.42) compared to males (ROR 4.17, 95% CI 2.91-5.99). Temporal analysis revealed an early-failure pattern, with 50.6% of events occurring within 180 days. These findings generate the hypothesis that sex-disaggregated pharmacovigilance in pediatrics, particularly for growth-modulating therapies, may reveal differential reporting patterns. Should these signals be validated in controlled prospective studies, they could inform the development of customized monitoring frameworks and dosing strategies aimed at potentially mitigating risks in hypothesized high-risk subgroups. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, LLC. FAU - Junyu, Xu AU - Junyu X AUID- ORCID: 0009-0006-9659-123 AD - Department of Pediatrics, The First Affiliated Hospital of Huzhou Normal University, First People's Hospital, Huzhou, Zhejiang, China. AD - School of Medicine, Huzhou Normal University, Huzhou, Zhejiang, China. FAU - Qian, Chen AU - Qian C AD - Department of Pediatrics, The First Affiliated Hospital of Huzhou Normal University, First People's Hospital, Huzhou, Zhejiang, China. AD - School of Medicine, Huzhou Normal University, Huzhou, Zhejiang, China. FAU - Jingnan, Xue AU - Jingnan X AD - School of Medicine, Huzhou Normal University, Huzhou, Zhejiang, China. AD - Department of Radiology, The First Affiliated Hospital of Huzhou Normal University, First People's Hospital, Huzhou, Zhejiang, China. FAU - Luying, Qi AU - Luying Q AD - School of Medicine, Huzhou Normal University, Huzhou, Zhejiang, China. AD - Department of Radiology, The First Affiliated Hospital of Huzhou Normal University, First People's Hospital, Huzhou, Zhejiang, China. FAU - Chen, Yuan AU - Chen Y AD - Department of Pediatrics, The First Affiliated Hospital of Huzhou Normal University, First People's Hospital, Huzhou, Zhejiang, China. FAU - Yan, Zhu AU - Yan Z AD - Department of Pediatrics, The First Affiliated Hospital of Huzhou Normal University, First People's Hospital, Huzhou, Zhejiang, China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Female MH - Male MH - United States/epidemiology MH - *Adverse Drug Reaction Reporting Systems/statistics & numerical data MH - United States Food and Drug Administration MH - Sex Factors MH - Child MH - *Growth Disorders/epidemiology/chemically induced MH - *Drug-Related Side Effects and Adverse Reactions/epidemiology MH - Adolescent MH - Child, Preschool PMC - PMC13384653 OTO - NOTNLM OT - FAERS OT - adverse events OT - disproportionality analysis OT - growth impairment OT - pediatric pharmacovigilance OT - sex-disaggregated COIS- The authors have no funding and conflicts of interest to declare. EDAT- 2026/07/18 06:38 MHDA- 2026/07/18 06:39 PMCR- 2026/07/17 CRDT- 2026/07/18 01:01 PHST- 2025/09/21 00:00 [received] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/07/18 06:39 [medline] PHST- 2026/07/18 06:38 [pubmed] PHST- 2026/07/18 01:01 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - 00005792-202607170-00066 [pii] AID - MD-D-25-12003 [pii] AID - 10.1097/MD.0000000000049802 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jul 17;105(29):e49802. doi: 10.1097/MD.0000000000049802. PMID- 42469779 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260912 IS - 1471-2474 (Electronic) IS - 1471-2474 (Linking) VI - 27 IP - 1 DP - 2026 Jul 17 TI - Prevalence and associated factors of musculoskeletal pain among university students in Saudi Arabia: an analytical cross-sectional study. LID - 10.1186/s12891-026-10228-x [doi] LID - 764 AB - BACKGROUND: Musculoskeletal pain is common among university students and may be influenced by prolonged sitting, digital-device use, suboptimal ergonomic practices, and low physical activity. However, evidence from Saudi university settings remains limited. This study aimed to estimate the 12-month prevalence and anatomical distribution of musculoskeletal pain among university students at Al-Baha University and to examine its associations with ergonomic behaviours and physical activity levels. METHODS: This analytical cross-sectional study was conducted among university students aged >/= 18 years at Al-Baha University. Data were collected using self-administered questionnaires capturing demographics, 12-month musculoskeletal pain and affected body regions assessed using the Nordic Musculoskeletal Questionnaire (NMQ), and ergonomic practices. Participants reported physical-activity summaries from their smartphone health applications (Google Fit and Apple Health). Descriptive statistics, chi-square tests, Mann-Whitney U tests, and multivariable logistic regression were used to analyse the data and identify factors independently associated with musculoskeletal pain. Results are presented as odds ratios (ORs) with 95% confidence intervals (CIs), and model discrimination was assessed using the area under the receiver operating characteristic curve (AUC). RESULTS: Among 675 students, the mean age was 22.26 +/- 3.36 years; most participants were male (74.4%) and enrolled in health-sciences programs (85.2%). Overall, 85.0% reported musculoskeletal pain in the previous 12 months. The neck (47.6%), lower back (46.8%), and shoulders (34.2%) were the most affected regions. In multivariable analysis, internship-level students had higher odds of pain (OR = 15.05, 95% CI: 2.91-77.78, p = 0.001), and sitting 6-8 h/day was associated with higher odds of pain (OR = 13.95, 95% CI: 4.13-47.19, p < 0.001). Low daily physical activity time (< 15 min/day) was also associated with higher odds of pain (OR = 5.70, 95% CI: 2.14-15.16, p < 0.001). The model showed acceptable discrimination (AUC = 0.793, 95% CI: 0.742-0.843, p < 0.001), although specificity and calibration were limited. CONCLUSIONS: Musculoskeletal pain was common among university students at Al-Baha University, particularly in the neck, lower back, and shoulders. The findings suggest that prolonged sitting and selected physical-activity indicators are important associated factors. These findings may inform campus-based strategies promoting regular movement breaks, ergonomic study practices, and physical activity. CI - (c) 2026. The Author(s). FAU - Alghamdi, Wael AU - Alghamdi W AUID- ORCID: 0000-0002-2297-3255 AD - Faculty of Nursing, Al-Baha University, Al-Baha, Saudi Arabia. waelalghamdi@bu.edu.sa. LA - eng PT - Journal Article DEP - 20260717 PL - England TA - BMC Musculoskelet Disord JT - BMC musculoskeletal disorders JID - 100968565 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Cross-Sectional Studies MH - Male MH - *Musculoskeletal Pain/epidemiology/diagnosis MH - Female MH - Young Adult MH - *Students/statistics & numerical data MH - Universities MH - Prevalence MH - Adult MH - Risk Factors MH - Adolescent MH - Ergonomics MH - Surveys and Questionnaires MH - Exercise PMC - PMC13560120 OTO - NOTNLM OT - Ergonomics OT - Musculoskeletal pain OT - Physical activity OT - Prevalence OT - Sedentary behaviour OT - University students COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Research Ethics Committee/Institutional Review Board at Al-Baha University (Approval No. 46121733/2025, Date: 22 March 2025). The study was conducted in accordance with the principles of the Declaration of Helsinki. All participants provided informed consent before participating in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/18 00:38 MHDA- 2026/09/11 05:36 PMCR- 2026/07/17 CRDT- 2026/07/17 23:57 PHST- 2026/01/14 00:00 [received] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/09/11 05:36 [medline] PHST- 2026/07/18 00:38 [pubmed] PHST- 2026/07/17 23:57 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - 10.1186/s12891-026-10228-x [pii] AID - 10228 [pii] AID - 10.1186/s12891-026-10228-x [doi] PST - epublish SO - BMC Musculoskelet Disord. 2026 Jul 17;27(1):764. doi: 10.1186/s12891-026-10228-x. PMID- 42469757 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261015 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 26 IP - 1 DP - 2026 Jul 17 TI - Personality-based subgroup identification and psychological symptom patterns in adolescent male new psychoactive substance users: implications for targeted intervention. LID - 10.1186/s12888-026-08420-3 [doi] LID - 784 AB - BACKGROUND/OBJECTIVES: Adolescent new psychoactive substance (NPS) users represent a high-risk population with complex psychological needs that remain insufficiently characterized, limiting the development of targeted rehabilitation interventions. This study aimed to (1) characterize the personality trait profiles and psychological symptom patterns of adolescent NPS users undergoing compulsory drug rehabilitation relative to normative standards; (2) identify empirically derived personality-based subgroups within this population; and (3) examine differential psychological symptom patterns across identified subgroups to inform precision intervention design. METHODS: A cross-sectional study was conducted with 60 adolescent male participants (mean age = 17.2 +/- 1.9 years) recruited from a compulsory drug rehabilitation facility in Shandong Province, China. Participants completed a multimodal assessment battery comprising Cattell's 16 Personality Factor Questionnaire (16PF), the Personality Diagnostic Questionnaire-4+ (PDQ-4+), and the Symptom Checklist-90-Revised (SCL-90-R). Personality-based subgroups were identified using a two-stage cluster analysis (Ward's method followed by K-means), with cluster quality evaluated via Average Silhouette Width and split-sample Adjusted Rand Index. Between-cluster differences in psychological symptom profiles were examined using one-way ANOVA with Tukey post-hoc comparisons. Hierarchical multiple regression identified independent personality predictors of overall psychological distress (SCL-90-R Global Severity Index, GSI). RESULTS: Fourteen of 16 personality factors deviated significantly from Chinese adolescent norms (all corrected p < .05), with the largest deviations observed for Tension (Q4; d = 1.38), Rule-Consciousness (G; d = 1.30 downward arrow), Apprehension (O; d = 1.24), and Emotional Stability (C; d = 1.13 downward arrow). Overall psychological distress was pervasive, with 81.7% of participants exceeding the GSI clinical significance threshold (GSI >/= 1.0; mean GSI = 1.52 +/- 0.43). Paranoid Ideation emerged as the most severely elevated SCL-90-R dimension (d = 1.39), followed by Interpersonal Sensitivity (d = 1.09) and Anxiety (d = 1.02). Cluster analysis identified three empirically stable personality-based subgroups: Dysregulated-Hostile (n = 22, 36.7%), Anxious-Withdrawn (n = 21, 35.0%), and Impulsive-Sensation-Seeking (n = 17, 28.3%; Average Silhouette Width = 0.58; split-sample ARI = 0.71). The three clusters demonstrated clinically meaningful differential symptom profiles: the Dysregulated-Hostile cluster was characterized by elevated Hostility and Paranoid Ideation; the Anxious-Withdrawn cluster by elevated Anxiety, Depression, and Obsessive-Compulsive symptoms; and the Impulsive-Sensation-Seeking cluster by relatively lower overall distress with elevated personality disorder tendencies. Hierarchical regression revealed that 16PF personality factors explained an additional 48.7% of variance in GSI beyond demographic covariates (DeltaR(2) = 0.487, DeltaF(6, 49) = 14.38, p < .001), with Tension (Q4; beta = 0.318), Emotional Stability (C; beta = -0.312), and Apprehension (O; beta = 0.287) as the strongest independent predictors. CONCLUSIONS: Adolescent NPS users in compulsory rehabilitation present a distinctive high-risk personality configuration and a substantial psychological distress burden that is not uniformly distributed across the population. Three empirically derived personality-based subgroups with differential symptom profiles provide preliminary, hypothesis-generating evidence that should be validated in a larger, multisite cohort before informing the development of differentiated, precision intervention strategies. Personality assessment at treatment intake-particularly targeting Tension, Emotional Stability, and Apprehension-offers clinically meaningful predictive information for distress severity that substantially exceeds demographic screening alone. These findings complement the gut microbiota-exercise intervention framework being developed in our companion, currently in-press trial and represent a critical step toward a precision medicine model for adolescent NPS rehabilitation that integrates personality-based stratification with physiologically targeted exercise interventions. CI - (c) 2026. The Author(s). FAU - Yang, Jianlou AU - Yang J AD - Department of Health Services and Management, School of Sport Ma nagement, Shandong Sport University, Jinan, Shandong, 250102, China. FAU - Jin, Xin AU - Jin X AD - Department of Police Practical Skills Teaching and Research, Shandong Judicial Police Vocational College, Jinan, Shandong, 250200, China. FAU - Shi, Lei AU - Shi L AD - Rehabilitation Training Center, Shandong Luzhong Compulsory Isolation Drug Rehabilitation Center, Zibo, Shandong, 255311, China. FAU - Shi, Dapeng AU - Shi D AD - Rehabilitation Training Center, Shandong Luzhong Compulsory Isolation Drug Rehabilitation Center, Zibo, Shandong, 255311, China. FAU - Cui, Jingjing AU - Cui J AD - Department of Health Services and Management, School of Sport Ma nagement, Shandong Sport University, Jinan, Shandong, 250102, China. FAU - Wang, Kaixu AU - Wang K AD - Rehabilitation Training Center, Shandong Luzhong Compulsory Isolation Drug Rehabilitation Center, Zibo, Shandong, 255311, China. FAU - Liu, Haoyu AU - Liu H AD - Department of Health Services and Management, School of Sport Ma nagement, Shandong Sport University, Jinan, Shandong, 250102, China. FAU - Xing, Xiaodong AU - Xing X AD - Department of Health Services and Management, School of Sport Ma nagement, Shandong Sport University, Jinan, Shandong, 250102, China. FAU - Dong, Chen AU - Dong C AD - Department of Health Services and Management, School of Sport Ma nagement, Shandong Sport University, Jinan, Shandong, 250102, China. dongchen@sdpei.edu.cn. LA - eng GR - 25DJYJ13/Social Science Planning Project of Shandong Province/ PT - Journal Article DEP - 20260717 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 RN - 0 (Psychotropic Drugs) SB - IM MH - *Substance-Related Disorders/psychology/rehabilitation MH - *Psychotropic Drugs/adverse effects MH - China MH - Cluster Analysis MH - Humans MH - Male MH - Adolescent PMC - PMC13660315 OTO - NOTNLM OT - 16PF OT - Adolescents OT - Cluster analysis OT - Compulsory drug rehabilitation OT - New psychoactive substances OT - Personality traits OT - Precision intervention OT - Psychological symptoms OT - SCL-90-R COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethics Review Committee of the School of Sport Management, Shandong Sport University (Approval Number: SD2026043) in accordance with the Declaration of Helsinki. Clinical trial number: not applicable. Consent for publication: All authors gave their consent for publication. Competing interests: The authors declare no competing interests. EDAT- 2026/07/18 00:38 MHDA- 2026/10/13 05:31 PMCR- 2026/07/17 CRDT- 2026/07/17 23:57 PHST- 2026/04/30 00:00 [received] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/10/13 05:31 [medline] PHST- 2026/07/18 00:38 [pubmed] PHST- 2026/07/17 23:57 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - 10.1186/s12888-026-08420-3 [pii] AID - 8420 [pii] AID - 10.1186/s12888-026-08420-3 [doi] PST - epublish SO - BMC Psychiatry. 2026 Jul 17;26(1):784. doi: 10.1186/s12888-026-08420-3. PMID- 42469521 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261014 IS - 1437-1596 (Electronic) IS - 0937-9827 (Linking) VI - 140 IP - 6 DP - 2026 Nov TI - Population-specific dental maturity scores for forensic age estimation in turkish children: a percentile-based modeling approach. PG - 3861-3872 LID - 10.1007/s00414-026-03926-7 [doi] AB - Accurate age estimation in children and adolescents is essential for forensic identification; however, the direct application of dental age estimation methods developed from Western European populations may introduce systematic bias when applied to other populations. This study aimed to develop and validate population-specific age estimation models based on the Dental Maturity Score (DMS) using data obtained from Turkish children. A total of 4,009 panoramic radiographs from individuals aged 2-18 years (2,035 males and 1,974 females) were included. Of these, 3,206 individuals constituted the model development (training) cohort and 803 the independent validation (test) cohort. The seven left permanent mandibular teeth were assessed according to the Demirjian staging system, and sex-specific DMSs were calculated. The relationship between chronological age and DMS was modeled using moving average, Locally Weighted Scatterplot Smoothing (LOWESS), the Lambda-Mu-Sigma (LMS) method, piecewise polynomial regression, and polynomial- and spline-based quantile regression. Model performance was evaluated using the coefficient of determination (R(2)), mean absolute error (MAE), and Bland-Altman agreement analysis. Among the evaluated approaches, the polynomial- and spline-based quantile regression models demonstrated the best overall performance. In the independent validation cohort, the polynomial-based quantile regression model achieved an R(2) of 0.94 and an MAE of 0.75 years in males, and an R(2) of 0.92 and an MAE of 1.09 years in females. Among the population-specific models developed for Turkish children, the polynomial-based quantile regression model demonstrated the highest predictive accuracy and consistent performance in the independent validation cohort, indicating that it is a suitable approach for forensic age estimation. In contrast, the spline-based quantile regression model provides a useful reference framework for the clinical assessment of dental development. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Zilan, Sumeyye AU - Zilan S AD - Department of Pediatric Dentistry, Faculty of Dentistry, Ataturk University, Erzurum, Turkey. FAU - Sengul, Fatih AU - Sengul F AUID- ORCID: 0000-0001-6087-148X AD - Department of Pediatric Dentistry, Faculty of Dentistry, Ataturk University, Erzurum, Turkey. fsengul@atauni.edu.tr. LA - eng PT - Journal Article PT - Validation Study DEP - 20260718 PL - Germany TA - Int J Legal Med JT - International journal of legal medicine JID - 9101456 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Turkey MH - Child MH - Child, Preschool MH - Male MH - Radiography, Panoramic MH - Female MH - Adolescent MH - Regression Analysis MH - *Models, Statistical MH - Dentition, Permanent OTO - NOTNLM OT - Demirjian method OT - Dental maturity score OT - Forensic age estimation OT - Forensic odontology OT - Quantile regression OT - Turkish population COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the principles of the Declaration of Helsinki. Ethical approval was obtained from the Clinical Research Ethics Committee of Ataturk University Faculty of Medicine (Approval No. B.30.ATA.0.01.00/193; February 28, 2025). Because of the retrospective design of the study, the requirement for informed consent was waived by the Ethics Committee. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/07/18 00:38 MHDA- 2026/10/12 17:30 CRDT- 2026/07/17 23:23 PHST- 2026/02/13 00:00 [received] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/10/12 17:30 [medline] PHST- 2026/07/18 00:38 [pubmed] PHST- 2026/07/17 23:23 [entrez] AID - 10.1007/s00414-026-03926-7 [pii] AID - 10.1007/s00414-026-03926-7 [doi] PST - ppublish SO - Int J Legal Med. 2026 Nov;140(6):3861-3872. doi: 10.1007/s00414-026-03926-7. Epub 2026 Jul 18. PMID- 42469299 OWN - NLM STAT- Publisher LR - 20260717 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jul 17 TI - Germany's youth city versus rural dwellers engage in more moderate-to-vigorous physical activity. LID - 10.1038/s41598-026-61980-y [doi] AB - Rapid urbanization poses the question how city living impacts human physical activity, especially in the population of vulnerable youth. This study aimed to examine urban-rural differences in moderate-to-vigorous physical activity (MVPA) among children and adolescents in Germany in a large German national study, across two independent samples (Discovery study: N = 2734; Replication study: N = 1196) of children and adolescents (6-17 years), with accelerometer-assessed MVPA, and across two different urbanicity assessments. In both studies, city youth engaged in more total MVPA than rural youth and were more likely to comply with the physical activity guidelines of the World Health Organization. While city living and total MVPA were independent of age and gender, age groups differed regarding physical activity guideline compliance. These results point towards a potential positive implication of urbanization for physical activity and suggest actions to target rural areas for physical activity promotion, if findings are validated towards causality in future studies. CI - (c) 2026. The Author(s). FAU - Reichert, Markus AU - Reichert M AD - Department of Sport and Exercise Science, Faculty of Natural and Life Sciences, University of Salzburg, Schlossallee 49, 5400, Hallein, Austria. markus.reichert@plus.ac.at. AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. markus.reichert@plus.ac.at. AD - Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. markus.reichert@plus.ac.at. FAU - Nigg, Carina AU - Nigg C AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. carina.nigg2@unibe.ch. AD - Institute of Social and Preventive Medicine (ISPM), University of Bern, Mittelstrasse 43, 3012, Bern, Switzerland. carina.nigg2@unibe.ch. FAU - Fiedler, Janis AU - Fiedler J AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Brussler, Sarah AU - Brussler S AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Burchartz, Alexander AU - Burchartz A AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Jekauc, Darko AU - Jekauc D AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Limberger, Matthias F AU - Limberger MF AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Krell-Roesch, Janina AU - Krell-Roesch J AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - von Haaren-Mack, Birte AU - von Haaren-Mack B AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Ebner-Priemer, Ulrich W AU - Ebner-Priemer UW AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Niessner, Claudia AU - Niessner C AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Schipperijn, Jasper AU - Schipperijn J AD - Department of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Woll, Alexander AU - Woll A AD - Institute of Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. LA - eng GR - 01ER1503/Federal Ministry of Education and Research, Germany/ PT - Journal Article DEP - 20260717 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM OTO - NOTNLM OT - Adolescents OT - Children OT - Cities OT - Physical activity guidelines OT - Urbanization COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/18 04:01 MHDA- 2026/07/18 04:01 CRDT- 2026/07/17 23:17 PHST- 2024/08/26 00:00 [received] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/07/18 04:01 [medline] PHST- 2026/07/18 04:01 [pubmed] PHST- 2026/07/17 23:17 [entrez] AID - 10.1038/s41598-026-61980-y [pii] AID - 10.1038/s41598-026-61980-y [doi] PST - aheadofprint SO - Sci Rep. 2026 Jul 17. doi: 10.1038/s41598-026-61980-y. PMID- 42468921 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260924 IS - 1543-2777 (Electronic) IS - 0736-5829 (Linking) VI - 43 IP - 4 DP - 2026 Oct 1 TI - Feasibility and Efficacy of a Judo-Based Program for Adolescents With Intellectual Disabilities: A Multinational Pragmatic Controlled Trial. PG - 338-347 LID - 10.1123/apaq.2025-0183 [doi] AB - This study was conducted to examine the feasibility and potential efficacy of an adapted judo program for adolescents with intellectual disability using a pragmatic multicenter controlled design. A total of 127 participants (15.2 +/- 4.16 years) from six European countries were allocated to an experimental (n = 104) or control group (n = 23), primarily at school or classroom level, with partial nonrandom assignment due to practical constraints. The experimental group completed two 60-min sessions per week over one school year, while controls maintained usual activities. Feasibility was assessed through attendance and stakeholder ratings. Outcomes included physical fitness variables and quality of life (KidsLife), analyzed using adjusted linear mixed models. Participation and completion exceeded 80%, with minimal adverse events and high feasibility ratings. Significant Group x Time interactions (p < .001) indicated greater improvements in the experimental group, with large effect sizes (d = 1.15-1.31). FAU - Morales, Jose AU - Morales J AUID- ORCID: 0000-0001-5165-5195 AD - Faculty of Psychology, Education Sciences and Sport Blanquerna-Ramon Llull University, Barcelona, Spain. FAU - Pierantozzi, Emanuela AU - Pierantozzi E AUID- ORCID: 0000-0002-4405-9552 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy. FAU - Guerra-Balic, Miriam AU - Guerra-Balic M AUID- ORCID: 0000-0002-9197-3179 AD - Faculty of Psychology, Education Sciences and Sport Blanquerna-Ramon Llull University, Barcelona, Spain. FAU - Nieto-Guisado, Ainhoa AU - Nieto-Guisado A AUID- ORCID: 0000-0002-3649-9830 AD - Faculty of Psychology, Education Sciences and Sport Blanquerna-Ramon Llull University, Barcelona, Spain. FAU - Fukuda, David H AU - Fukuda DH AUID- ORCID: 0000-0002-4299-7764 AD - School of Kinesiology and Rehabilitation Sciences, University of Central Florida, Orlando, FL, USA. FAU - Ortiz-Castejon, Oscar AU - Ortiz-Castejon O AUID- ORCID: 0009-0007-7581-5828 AD - Faculty of Psychology, Education Sciences and Sport Blanquerna-Ramon Llull University, Barcelona, Spain. FAU - Maussier, Nicole AU - Maussier N AUID- ORCID: 0009-0009-1367-8834 AD - Department of Sport, Health and Human Sciences, University "Foro Italico," Rome, Italy. FAU - Moragas, Marta AU - Moragas M AUID- ORCID: 0000-0001-9881-3154 AD - Faculty of Psychology, Education Sciences and Sport Blanquerna-Ramon Llull University, Barcelona, Spain. LA - eng PT - Journal Article PT - Multicenter Study PT - Pragmatic Clinical Trial DEP - 20260716 PL - United States TA - Adapt Phys Activ Q JT - Adapted physical activity quarterly : APAQ JID - 8701671 SB - IM MH - Humans MH - Adolescent MH - Feasibility Studies MH - *Martial Arts MH - *Intellectual Disability/rehabilitation MH - Quality of Life MH - Female MH - Male MH - Physical Fitness MH - Europe OTO - NOTNLM OT - adapted judo OT - educational intervention OT - health promotion in youth OT - physical fitness OT - quality of life EDAT- 2026/07/18 00:38 MHDA- 2026/09/23 23:55 CRDT- 2026/07/17 19:32 PHST- 2025/12/10 00:00 [received] PHST- 2026/04/08 00:00 [revised] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/09/23 23:55 [medline] PHST- 2026/07/18 00:38 [pubmed] PHST- 2026/07/17 19:32 [entrez] AID - 10.1123/apaq.2025-0183 [doi] PST - epublish SO - Adapt Phys Activ Q. 2026 Jul 16;43(4):338-347. doi: 10.1123/apaq.2025-0183. Print 2026 Oct 1. PMID- 42468724 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260923 IS - 1541-6100 (Electronic) IS - 0022-3166 (Print) IS - 0022-3166 (Linking) VI - 156 IP - 9 DP - 2026 Sep TI - Longitudinal Changes in Healthy Eating Index-2020 Score and Impacts on Body Mass Index among Adolescents in the Growing Up Today Study: A Prospective Cohort Study. PG - 101735 LID - S0022-3166(26)00384-6 [pii] LID - 10.1016/j.tjnut.2026.101735 [doi] AB - BACKGROUND: The Dietary Guidelines for Americans informs the design of nutrition programs targeted at improving health across the life course, including for adolescents, a population with suboptimal diet quality. The associations between adherence to the Guidelines and longitudinal health outcomes among adolescents, however, are unclear. OBJECTIVES: We leveraged 7 y of data from the Growing Up Today Study, a prospective cohort study, to evaluate associations between concurrent changes in total or component Healthy Eating Index-2020 (HEI-2020) scores, a measure of adherence to the Guidelines, and changes in body mass index [BMI (in kg/m(2))], a targeted outcome of the Guidelines, in United States adolescents. METHODS: We analyzed data from a prospective longitudinal cohort with enrollment cycles in 1996 (n = 14,233) and 2004 (n = 7898). We calculated HEI-2020 and BMI from validated food frequency questionnaires and self-reported height/weight. Multivariate fixed-effects regression models, stratified by sex, were used to estimate associations between within-child changes in HEI-2020 and changes in BMI. We assessed interactions by concurrent adolescent BMI category and age. RESULTS: After covariate adjustment, a 10-point increase in total HEI-2020 was associated with 0.09 [95% confidence interval (CI): 0.051, 0.121] and 0.04 (95% CI: 0.011, 0.066) decreases in BMI for boys and girls, respectively. Of the 13 HEI-2020 components, only the greens/beans, fatty acids adequacy scores, and saturated fatty acid moderation scores were inversely related to BMI. A 1-point increase in the dairy component was associated with mean increases of 0.02 for boys and girls. Associations between total HEI-2020 and BMI were stronger for youth classified as overweight/obese and for older age, although associations were still relatively small. CONCLUSIONS: Improved adherence to the Dietary Guidelines, 2020-2025, was associated with small, though clinically insignificant, decreases in mean BMI among adolescents. Relationships for specific HEI components were heterogeneous and warrant further study. CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Lee, Matthew M AU - Lee MM AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States. Electronic address: matthewlee@kurtosisresearch.com. FAU - Poole, Mary Kathryn AU - Poole MK AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Chen, Jarvis T AU - Chen JT AD - Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Gortmaker, Steven L AU - Gortmaker SL AD - Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Stephenson, Briana Joy K AU - Stephenson BJK AD - Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Haines, Jess AU - Haines J AD - Department of Family Relations & Applied Nutrition, University of Guelph, Guelph, ON, Canada. FAU - Chavarro, Jorge E AU - Chavarro JE AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States. FAU - Diamantis, Dimitrios V AU - Diamantis DV AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Kenney, Erica L AU - Kenney EL AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, United States. LA - eng GR - T32 HL098048/HL/NHLBI NIH HHS/United States GR - U01 CA176726/CA/NCI NIH HHS/United States GR - U01 HL145386/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260717 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 SB - IM MH - Humans MH - *Body Mass Index MH - Adolescent MH - Female MH - Prospective Studies MH - *Diet, Healthy MH - Male MH - Longitudinal Studies MH - Nutrition Policy MH - Child MH - United States PMC - PMC13531323 MID - NIHMS2202929 OTO - NOTNLM OT - BMI OT - Dietary Guidelines for Americans OT - Growing Up Today Study OT - Healthy Eating Index OT - child nutrition OT - diet quality OT - longitudinal cohort study OT - nutrition epidemiology OT - obesity OT - prospective cohort study COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/07/18 00:38 MHDA- 2026/09/04 23:36 PMCR- 2026/09/02 CRDT- 2026/07/17 19:12 PHST- 2026/04/28 00:00 [received] PHST- 2026/06/22 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/09/04 23:36 [medline] PHST- 2026/07/18 00:38 [pubmed] PHST- 2026/07/17 19:12 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - S0022-3166(26)00384-6 [pii] AID - 10.1016/j.tjnut.2026.101735 [doi] PST - ppublish SO - J Nutr. 2026 Sep;156(9):101735. doi: 10.1016/j.tjnut.2026.101735. Epub 2026 Jul 17. PMID- 42468723 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261013 IS - 1541-6100 (Electronic) IS - 0022-3166 (Linking) VI - 156 IP - 10 DP - 2026 Oct TI - Impact of Behavior Change Communication and Small-Quantity-Lipid-Based Nutrient Supplementation on Nutrient Intake and Adequacy among 12-Month-Old Infants in Rural Zimbabwe: Substudy of a Cluster-Randomized Trial. PG - 101728 LID - S0022-3166(26)00377-9 [pii] LID - 10.1016/j.tjnut.2026.101728 [doi] AB - BACKGROUND: Poor complementary feeding practices between 6 and 24 mo are a major driver of infant undernutrition. We evaluated an infant and young child feeding (IYCF) intervention combining behavior change communication (BCC) and small-quantity-lipid-based nutrient supplement (SQ-LNS) within the Sanitation Hygiene Infant Nutrition Efficacy (SHINE) cluster-randomized trial in rural Zimbabwe. OBJECTIVES: We aimed to assess the impact of the IYCF intervention on infant nutrient intake from complementary foods assessed by 24-h dietary recall. METHODS: The SHINE trial was a cluster-randomized 2 x 2 factorial trial assessing individual and combined effects of IYCF and water, sanitation, and hygiene (WASH) interventions on stunting and anemia in rural Zimbabwe (NCT01824940). We conducted multipass 24-h dietary recalls among 194 randomly selected caregivers of 12-mo-old infants. Nutrient intake and adequacy were compared between children in the IYCF intervention arms (BCC + daily SQ-LNS; n = 99) and non-IYCF arms (standard of care with or without WASH; n = 94), with analyses conducted both including and excluding the contribution of SQ-LNS-derived nutrients, using the measurement-error method. RESULTS: Energy intake was higher in IYCF compared with non-IYCF infants [531 (404) compared with 426 (272) kcal/d; P = 0.03]. IYCF infants had greater micronutrient intake and adequacy (vitamin A, folate, calcium, iron and zinc; all P < 0.01). However, many children still did not meet their dietary requirements, particularly for calcium and folate. Intakes of all macronutrients and micronutrients from nonsupplement foods did not differ significantly between the IYCF and non-IYCF groups, which suggests that the SQ-LNS provided all the nutritional benefit and did not replace nonsupplement food intake. CONCLUSIONS: The IYCF intervention improved energy and micronutrient intake and improved micronutrient adequacy, primarily through SQ-LNS, with no displacement of other food intake. However, no differences in intake from nonsupplement foods were observed, indicating that BCC alone had no effect on complementary feeding. This trial was registered at clinicaltrials.gov as NCT01883193 (https://clinicaltrials.gov/study/NCT01824940). CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Fundira, Dadirai AU - Fundira D AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States; Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe. FAU - Mbuya, Mduduzi Nn AU - Mbuya MN AD - Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe; Global Alliance for Improved Nutrition, Geneva, Switzerland. FAU - Larson, Elisabeth A AU - Larson EA AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Chasekwa, Bernard AU - Chasekwa B AD - Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe. FAU - Humphrey, Jean H AU - Humphrey JH AD - Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe; Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. FAU - Pelto, Gretel AU - Pelto G AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Rasmussen, Kathleen M AU - Rasmussen KM AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Stoltzfus, Rebecca J AU - Stoltzfus RJ AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Smith, Laura E AU - Smith LE AD - Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe; Department of Public and Ecosystem Health, Cornell University, Ithaca, NY, United States. Electronic address: les36@cornell.edu. LA - eng SI - ClinicalTrials.gov/NCT01824940 SI - ClinicalTrials.gov/NCT01883193 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260717 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 RN - 0 (Lipids) RN - 0 (Micronutrients) RN - 0 (Dietary Fats) SB - IM MH - Humans MH - Infant MH - Zimbabwe MH - *Dietary Supplements MH - *Infant Nutritional Physiological Phenomena MH - Female MH - Male MH - Rural Population MH - Energy Intake MH - *Nutrients/administration & dosage MH - *Lipids/administration & dosage MH - Micronutrients/administration & dosage MH - *Dietary Fats/administration & dosage MH - Diet OTO - NOTNLM OT - behavior change communication OT - dietary recall OT - macronutrient intake OT - micronutrient intake OT - small-quantity-lipid-based nutrient supplement COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/07/18 00:38 MHDA- 2026/10/09 23:31 CRDT- 2026/07/17 19:12 PHST- 2026/01/09 00:00 [received] PHST- 2026/07/01 00:00 [revised] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/10/09 23:31 [medline] PHST- 2026/07/18 00:38 [pubmed] PHST- 2026/07/17 19:12 [entrez] AID - S0022-3166(26)00377-9 [pii] AID - 10.1016/j.tjnut.2026.101728 [doi] PST - ppublish SO - J Nutr. 2026 Oct;156(10):101728. doi: 10.1016/j.tjnut.2026.101728. Epub 2026 Jul 17. PMID- 42467974 OWN - NLM STAT- MEDLINE DCOM- 20261005 LR - 20261016 IS - 1473-5687 (Electronic) IS - 0954-691X (Linking) VI - 38 IP - 11 DP - 2026 Nov 1 TI - COMPLY-CATeD: Celiac Adherence in Teens Diagnosed: an Italian multicentric study. PG - 1305-1310 LID - 10.1097/MEG.0000000000003227 [doi] AB - OBJECTIVES: Gluten-free diet (GFD) is, to date, the only effective therapeutic intervention for coeliac disease (CeD). Evaluation of dietary adherence is of the utmost importance in the management of CeD. However, in the paediatric population, there is limited data concerning the adherence to the GFD in patients diagnosed via bioptic confirmation compared to those diagnosed through the biopsy-sparing method, according to the ESPGHAN 2012 guidelines. In this multicentric study, we investigated dietary adherence in a group of adolescents with CeD, comparing patients diagnosed with the two different diagnostic modalities, and we proposed the validation of an evaluation tool for the GFD compliance in this population. METHODS: A total of 206 patients aged 14-18 years, diagnosed between 2012 and 2019, all with CeD and on a GFD for at least 2 years, were included. Adherence was assessed using the Leffler questionnaire [Celiac Dietary Adherence Test (CDAT)] and the Biagi score. RESULTS: Among participants, 81.1% had been diagnosed through biopsy. No significant difference in Biagi scores was observed between the two groups ( P = 0.057). Regarding the CDAT, poor or suboptimal adherence (score: >/=13) was identified in 66 patients diagnosed by biopsy and 12 patients diagnosed by the biopsy-sparing approach ( P = 0.362). A multivariate analysis exploring the influence of diagnostic method, age at diagnosis, and education level on CDAT scores did not reach statistical significance ( P = 0.1, R2 = 0.031). CONCLUSION: Adherence to a GFD does not differ between adolescents diagnosed by biopsy and those diagnosed through the biopsy-sparing approach, irrespective of age at diagnosis or educational level. CI - Copyright (c) 2026 Wolters Kluwer Health, LLC. All rights reserved. FAU - Morelli, Annalisa AU - Morelli A AD - Department of Medicine, Surgery and Dentistry 'Scuola Medica Salernitana', Pediatrics Section, University of Salerno, Baronissi. AD - Gastroenterology and Nutritional Rehabilitation Unit, 'Bambino Gesu' Children's Hospital, IRCCS. FAU - Montuori, Monica AU - Montuori M AD - Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome. FAU - Ferretti, Francesca AU - Ferretti F AD - Gastroenterology and Nutritional Rehabilitation Unit, 'Bambino Gesu' Children's Hospital, IRCCS. FAU - Diamanti, Antonella AU - Diamanti A AD - Gastroenterology and Nutritional Rehabilitation Unit, 'Bambino Gesu' Children's Hospital, IRCCS. FAU - Francisci, Silvia AU - Francisci S AD - Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome. FAU - Oliva, Salvatore AU - Oliva S AD - Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome. FAU - Dipasquale, Valeria AU - Dipasquale V AD - Pediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adulthood and Childhood 'G. Barresi', University of Messina, Messina. FAU - Romano, Claudio AU - Romano C AD - Pediatric Gastroenterology and Cystic Fibrosis Unit, Department of Human Pathology in Adulthood and Childhood 'G. Barresi', University of Messina, Messina. FAU - Monzani, Alice AU - Monzani A AD - Division of Pediatrics, Department of Health Sciences, University of Piemonte Orientale, Novara. FAU - Graziano, Francesco AU - Graziano F AD - Pediatric Unit, Villa Sofia Cervello Hospital, Palermo. FAU - Nosratian, Valentina AU - Nosratian V AD - Pediatric Gastroenterology and Endoscopy Unit, IRCCS Istituto Giannina Gaslini, Genova. FAU - Malerba, Federica AU - Malerba F AD - Pediatric Gastroenterology and Endoscopy Unit, IRCCS Istituto Giannina Gaslini, Genova. FAU - Crocco, Marco AU - Crocco M AD - Pediatric Gastroenterology and Endoscopy Unit, IRCCS Istituto Giannina Gaslini, Genova. FAU - Banzato, Claudia AU - Banzato C AD - Department of Pediatrics, Woman's and Child's University Hospital of Verona, Verona. FAU - Valitutti, Francesco AU - Valitutti F AD - Department of Medicine and Surgery, Pediatrics section, University of Perugia, Perugia, Italy. FAU - Trovato, Chiara Maria AU - Trovato CM AD - Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome. CN - 'Food-induced disease' study group of SIGENP LA - eng PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20260930 PL - England TA - Eur J Gastroenterol Hepatol JT - European journal of gastroenterology & hepatology JID - 9000874 SB - IM MH - Humans MH - Adolescent MH - *Celiac Disease/diet therapy/diagnosis/psychology MH - *Diet, Gluten-Free MH - Female MH - *Patient Compliance/statistics & numerical data MH - Male MH - Italy MH - Biopsy MH - Surveys and Questionnaires MH - *Adolescent Behavior OTO - NOTNLM OT - coeliac disease in adolescents OT - dietary adherence OT - gluten-free diet EDAT- 2026/07/17 19:17 MHDA- 2026/10/05 17:31 CRDT- 2026/07/17 16:54 PHST- 2026/10/05 17:31 [medline] PHST- 2026/07/17 19:17 [pubmed] PHST- 2026/07/17 16:54 [entrez] AID - 00042737-990000000-00721 [pii] AID - 10.1097/MEG.0000000000003227 [doi] PST - ppublish SO - Eur J Gastroenterol Hepatol. 2026 Nov 1;38(11):1305-1310. doi: 10.1097/MEG.0000000000003227. Epub 2026 Sep 30. PMID- 42467570 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260813 IS - 1469-0705 (Electronic) IS - 0960-7692 (Print) IS - 0960-7692 (Linking) VI - 68 IP - 2 DP - 2026 Aug TI - Development and external validation of prognostic markers to predict pump-twin survival in twin reversed arterial perfusion sequence. PG - 220-228 LID - 10.1002/uog.70256 [doi] AB - OBJECTIVES: To evaluate the outcome of monochorionic diamniotic (MCDA) pregnancies complicated by twin reversed arterial perfusion (TRAP) sequence and to evaluate potential prognostic ultrasound markers as predictors of pump-twin survival. METHODS: This was a retrospective cohort study of MCDA twin pregnancies diagnosed with TRAP sequence at two medical centers in China between January 2010 and December 2024. All cases were analyzed retrospectively for intrauterine course and outcome. Cases that underwent expectant management were assigned to the primary cohort (cases from the First Affiliated Hospital of Sun Yat-sen University, Guangzhou) or the external-validation cohort (cases from Dalian Women and Children's Medical Group, Dalian). Cases that underwent intrauterine intervention at the First Affiliated Hospital of Sun Yat-sen University were assigned to the intrauterine-intervention cohort. The following parameters were evaluated in the primary and external-validation cohorts for their predictive value regarding pump-twin survival: in the first trimester, the crown-rump length (CRL) and nuchal translucency thickness of the pump twin, the upper pole-rump length (URL) of the acardiac twin, the URL/CRL ratio, and the presence of reversed a-wave in the ductus venosus and the umbilical artery pulsatility index (UA-PI) in the acardiac twin; and in the second trimester, the URL of the acardiac twin, the estimated fetal weight (EFW) of each twin, the twin weight ratio (TWR) (EFW(acardiac twin)/EFW(pump twin)) and the UA-PI of each twin. Univariate Cox regression analysis was performed to identify the parameters associated with pump-twin survival. Performance was evaluated by the area under the receiver-operating-characteristics curves (AUCs) and calibration curves. Finally, Kaplan-Meier survival analysis was performed. RESULTS: A total of 117 MCDA pregnancies with TRAP sequence were included in the analysis: 55 in the primary cohort, 38 in the intrauterine-intervention cohort and 24 in the external-validation cohort. The overall pump-twin survival rate was 65.8% (77/117). Three variables (URL and URL/CRL ratio in the first trimester and TWR in the second trimester) were identified to be independent risk factors influencing pump-twin survival in both the primary and external-validation cohorts. The AUCs were indicative of good predictive discrimination in both cohorts: 0.811 (95% CI, 0.667-0.956) for URL, 0.780 (95% CI, 0.619-0.941) for the URL/CRL ratio and 0.859 (95% CI, 0.730-0.988) for TWR in the primary cohort; and 0.844 (95% CI, 0.662-1.000) for URL, 0.823 (0.633-1.000) for the URL/CRL ratio and 0.925 (95% CI, 0.766-1.000) for TWR in the external-validation cohort. The optimal cut-off values were 4.85 cm for URL, 0.54 for the URL/CRL ratio and 0.295 for TWR in the primary cohort. The TWR exhibited good calibration, but URL and the URL/CRL ratio exhibited poor calibration. Kaplan-Meier survival analysis revealed that pump twins with TWR >/= 0.295 experienced a significantly shorter intrauterine survival duration in both the primary and external-validation cohorts, and pump twins with URL >/= 4.85 cm or URL/CRL ratio >/= 0.54 experienced a significantly shorter intrauterine survival duration in the primary cohort. However, the optimal cut-offs of URL and the URL/CRL ratio showed no statistical difference in the external-validation cohort. CONCLUSION: After 14 + 0 weeks' gestation, the threshold of TWR < 0.295 can reliably predict survival of the pump twin in MCDA pregnancies with TRAP sequence. However, the predictive value of URL and the URL/CRL ratio in the first trimester for pump-twin survival is poor. A well-designed prospective multicenter study is warranted to develop a first-trimester multivariable predictive model with enhanced predictive performance. (c) 2026 International Society of Ultrasound in Obstetrics and Gynecology. CI - (c) 2026 International Society of Ultrasound in Obstetrics and Gynecology. FAU - Wu, L-H AU - Wu LH AUID- ORCID: 0000-0003-0354-3396 AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. FAU - Yang, Y-Y AU - Yang YY AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. FAU - Shen, H AU - Shen H AUID- ORCID: 0000-0002-9576-2619 AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. FAU - Du, L AU - Du L AUID- ORCID: 0000-0001-5049-2267 AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. FAU - Liu, Y AU - Liu Y AD - Department of Ultrasound, Dalian Women and Children's Medical Group, Dalian, China. FAU - Peng, R AU - Peng R AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. FAU - Xie, H-N AU - Xie HN AUID- ORCID: 0000-0002-1705-1328 AD - Department of Ultrasonic Medicine, First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260717 PL - England TA - Ultrasound Obstet Gynecol JT - Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology JID - 9108340 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Retrospective Studies MH - Prognosis MH - *Pregnancy, Twin MH - *Ultrasonography, Prenatal MH - *Fetofetal Transfusion/diagnostic imaging/mortality MH - Crown-Rump Length MH - Predictive Value of Tests MH - China MH - Adult MH - Nuchal Translucency Measurement MH - Pregnancy Outcome MH - Umbilical Arteries/diagnostic imaging/embryology PMC - PMC13432978 OTO - NOTNLM OT - TRAP sequence OT - prognostic predictors OT - pump-twin survival OT - twin reversed arterial perfusion sequence OT - ultrasound EDAT- 2026/07/17 19:17 MHDA- 2026/08/03 18:37 PMCR- 2026/08/03 CRDT- 2026/07/17 13:03 PHST- 2026/01/28 00:00 [revised] PHST- 2025/11/05 00:00 [received] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/08/03 18:37 [medline] PHST- 2026/07/17 19:17 [pubmed] PHST- 2026/07/17 13:03 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - UOG70256 [pii] AID - 10.1002/uog.70256 [doi] PST - ppublish SO - Ultrasound Obstet Gynecol. 2026 Aug;68(2):220-228. doi: 10.1002/uog.70256. Epub 2026 Jul 17. PMID- 42464896 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260828 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 3 DP - 2026 Jul TI - Feasibility and Readiness for Scaling-Up Multiple Micronutrient Supplements in Nepal: A Qualitative Study Using the Expandnet Scaling-Up Framework. PG - e70231 LID - 10.1111/mcn.70231 [doi] LID - e70231 AB - Micronutrient deficiencies in pregnancy remain a critical public health issue in Nepal, where iron-folic acid (IFA) supplementation alone has not fully addressed maternal and neonatal risks. Multiple micronutrient supplements (MMS) promise broader nutritional benefits; however, real-world guidance for their effective and equitable integration into routine maternal care is lacking. A qualitative study, guided by the ExpandNet scaling-up framework, was conducted from February to March 2025, including 28 focus group discussions with antenatal care (ANC) providers and female community health volunteers (FCHVs) and 40 key informant interviews with policymakers at different levels of the health system. Data was analyzed thematically to identify perceived facilitators and barriers to MMS adoption, institutionalization, and scale-up, and equitable implementation. Stakeholders viewed MMS as offering clear advantages over IFA, citing broader micronutrient coverage and fewer side effects that could improve adherence. However, they identified several system-level requirements for successful scale-up, including formal policy integration, sustainable financing, strengthened procurement and supply chains, and adequate storage capacity at facilities. FCHVs and ANC providers emphasized the need for clearer role definitions, improved training, and manageable counseling workloads. Persistent community-level barriers-such as concerns about tablet size, misconceptions about fetal growth, and low trust in free medicines-were seen as risks to equitable uptake. Respondents highlighted community engagement, culturally tailored counseling, and consistent support for FCHVs and ANC providers as essential to ensuring effective and equitable MMS adoption. Stakeholders in Nepal view MMS as a promising strategy to improve maternal and newborn nutrition, but its potential depends on strong policy commitment, adequate and sustainable financing, and community-centered implementation. Addressing product-related concerns, strengthening counseling and trust in public services, and ensuring uninterrupted supply chains are essential to MMS scale-up, including translating its introduction into equitable and meaningful gains in maternal and child nutrition. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Hoang, Mai-Anh AU - Hoang MA AD - Helen Keller Intl, New York, New York, USA. FAU - Joshi, Nira AU - Joshi N AD - New ERA, Kathmandu, Bagmati, Nepal. FAU - Cunningham, Kenda AU - Cunningham K AD - Helen Keller Intl, New York, New York, USA. AD - International Food Policy Research Institute, London, UK. FAU - Singh, Usha AU - Singh U AD - New ERA, Kathmandu, Bagmati, Nepal. FAU - Lal, Bibek Kumar AU - Lal BK AD - Family Welfare Division, Ministry of Health and Food Safety, Kathmandu, Bagmati, Nepal. FAU - Thapa, Lila Bikram AU - Thapa LB AD - Family Welfare Division, Ministry of Health and Food Safety, Kathmandu, Bagmati, Nepal. FAU - Pandey, Pooja AU - Pandey P AD - Helen Keller Intl, Kathmandu, Bagmati, Nepal. FAU - Klemm, Rolf AU - Klemm R AD - Helen Keller Intl, New York, New York, USA. AD - Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Rana, Yashodhara AU - Rana Y AD - Eleanor Crook Foundation, Washington, D.C., USA. FAU - Pokhrel, Sudip AU - Pokhrel S AD - Eleanor Crook Foundation, Washington, D.C., USA. FAU - Poudel, Sasmita AU - Poudel S AD - Helen Keller Intl, Kathmandu, Bagmati, Nepal. LA - eng GR - 66677/Eleanor Crook Foundation/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 RN - 0 (Micronutrients) RN - 935E97BOY8 (Folic Acid) SB - IM MH - Humans MH - *Micronutrients/administration & dosage/deficiency MH - Nepal MH - *Dietary Supplements MH - Female MH - Pregnancy MH - *Prenatal Care/methods MH - Qualitative Research MH - Focus Groups MH - Feasibility Studies MH - Adult MH - Folic Acid/administration & dosage PMC - PMC13377524 OTO - NOTNLM OT - ExpandNet OT - Nepal OT - antenatal care OT - implementation science OT - maternal nutrition OT - multiple micronutrient supplementation OT - qualitative research OT - scale-up COIS- YR and SPo, who are employed by Eleanor Crook Foundation, provided technical guidance on study design and data collection. NJ, US, and KC report a relationship with Helen Keller Intl that includes consulting support and travel reimbursement. All other authors report no conflicts of interest. EDAT- 2026/07/17 17:25 MHDA- 2026/07/17 17:26 PMCR- 2026/07/17 CRDT- 2026/07/17 06:13 PHST- 2026/06/02 00:00 [revised] PHST- 2026/03/23 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/07/17 17:26 [medline] PHST- 2026/07/17 17:25 [pubmed] PHST- 2026/07/17 06:13 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - MCN70231 [pii] AID - 10.1111/mcn.70231 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jul;22(3):e70231. doi: 10.1111/mcn.70231. PMID- 42464825 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260717 IS - 2239-253X (Electronic) IS - 0003-469X (Linking) VI - 97 IP - 7 DP - 2026 Jul 14 TI - Preoperative Inflammatory and Nutritional Indices as Predictors of Infectious Complications Following Elective Cesarean Section in Patients With Gestational Diabetes Mellitus: A Retrospective Study. PG - 1292-1299 LID - 10.62713/aic.4544 [doi] AB - AIM: Postoperative infection is a significant complication that may adversely affect maternal recovery following cesarean section. Patients with gestational diabetes mellitus (GDM) may be at increased risk due to metabolic dysregulation and altered immune function. This study aimed to investigate preoperative risk factors for infectious complications following elective cesarean section in patients with GDM, with a focus on readily obtainable inflammatory and nutritional indices. METHODS: This retrospective study included 383 patients with GDM who underwent elective cesarean section at Tongxiang Maternity and Child Health Care Hospital between January 2022 and February 2025. Preoperative inflammatory indices, including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and C-reactive protein (CRP), as well as nutritional indices, including prognostic nutritional index (PNI) and hemoglobin (Hb), were collected. Univariate and multivariate logistic regression analyses were performed to identify risk factors for postoperative infection, and a risk stratification approach based on inflammatory and nutritional indices was developed. RESULTS: Among the 383 patients, 72 (18.8%) developed postoperative infections. Multivariable analysis identified elevated CRP (odds ratio (OR) = 2.383, 95% confidence interval (CI): 1.669-4.427), decreased PNI (OR = 0.680, 95% CI: 0.507-0.842), decreased hemoglobin (OR = 0.854, 95% CI: 0.746-0.945), and elevated PLR (OR = 1.046, 95% CI: 1.006-1.101) as independent risk factors for postoperative infection (all p < 0.05). Receiver operating characteristic (ROC) analysis demonstrated good discriminative performance of the inflammatory and nutritional indices, with CRP showing the strongest performance. Risk stratification based on the number of these factors (CRP, PLR, PNI, Hb) showed infection rates of 0.0%, 1.4%, 14.1%, 84.2%, and 100.0% for patients with 0, 1, 2, 3, and 4 factors, respectively (trend test p < 0.001). CONCLUSIONS: Preoperative elevation of inflammatory markers (CRP, PLR) and impairment of nutritional status (PNI, Hb) are independent risk factors for post-cesarean infection in patients with GDM. Preoperative risk assessment incorporating these indices may facilitate identification of high-risk patients and support targeted perioperative management strategies. CI - (c) Copyright: (c) 2026 The Author(s). FAU - Zhang, Xiaoli AU - Zhang X AD - Department of Obstetrics, Tongxiang Maternity and Child Health Care Hospital, 314500 Jiaxing, Zhejiang, China. FAU - Chen, Chen AU - Chen C AD - Department of Obstetrics, Tongxiang Maternity and Child Health Care Hospital, 314500 Jiaxing, Zhejiang, China. LA - eng PT - Journal Article PL - Italy TA - Ann Ital Chir JT - Annali italiani di chirurgia JID - 0372343 RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Humans MH - Female MH - Retrospective Studies MH - Pregnancy MH - *Diabetes, Gestational/blood MH - *Cesarean Section/adverse effects MH - Adult MH - Risk Factors MH - C-Reactive Protein/analysis MH - Elective Surgical Procedures MH - *Postoperative Complications/epidemiology/etiology MH - *Inflammation/blood MH - *Nutrition Assessment MH - *Nutritional Status MH - Preoperative Period OTO - NOTNLM OT - cesarean section OT - gestational diabetes mellitus OT - inflammatory indices OT - nutritional status OT - postoperative infection COIS- The authors declare no conflict of interest. EDAT- 2026/07/17 06:44 MHDA- 2026/07/17 12:41 CRDT- 2026/07/17 05:16 PHST- 2026/01/12 00:00 [received] PHST- 2026/02/06 00:00 [revised] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/07/17 12:41 [medline] PHST- 2026/07/17 06:44 [pubmed] PHST- 2026/07/17 05:16 [entrez] AID - S0003-469X(26)00136-0 [pii] AID - 10.62713/aic.4544 [doi] PST - ppublish SO - Ann Ital Chir. 2026 Jul 14;97(7):1292-1299. doi: 10.62713/aic.4544. PMID- 42464261 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261014 IS - 1465-993X (Electronic) IS - 1465-9921 (Print) IS - 1465-9921 (Linking) VI - 27 IP - 1 DP - 2026 Jul 17 TI - Aspartame and asthma: immunomodulatory effects on airway inflammation. LID - 10.1186/s12931-026-03820-1 [doi] LID - 393 AB - BACKGROUND AND OBJECTIVE: Asthma is a heterogeneous inflammatory airway disease influenced by genetic and environmental factors, including diet. Aspartame, a widely used artificial sweetener, has been implicated in immunometabolic changes that may affect asthma risk, but the potential role evidence remains limited. We aimed to examine the association between aspartame intake and asthma outcomes using integrated human analyses and complementary animal experiments. METHODS: Human data were obtained from 1021 adolescents in the Taiwan Puberty Longitudinal Study. Aspartame consumption, assessed using a validated food frequency questionnaire, was categorized as none, low, or high based on median intake. Asthma status was determined based on physician diagnosis and symptom history. In parallel, BALB/c mice were sensitized with house dust mite (HDM) extract and administered oral aspartame at 15, 30, or 60 mg/kg/day for 10 weeks. Immunological, microbiome, metabolic, and histopathological parameters were evaluated. RESULTS: Low aspartame consumption was significantly associated with higher odds of asthma (odds ratio = 2.852; 95% confidence interval: 1.038-8.014; p = 0.0369). In mice, aspartame exposure increased serum IgE levels, airway inflammation, and MMP-12 and MCP-1 expression. Although lung function changes were not statistically significant, histological analyses revealed more pronounced goblet cell hyperplasia, peribronchial collagen deposition, and eosinophilic infiltration, especially in the 60 mg/kg group. Aspartame also reduced microbial alpha-diversity and altered microbial composition. Short-chain fatty acids profiling revealed significantly decreased isobutyric, hexanoic, and heptanoic acid levels in aspartame-treated mice. CONCLUSIONS: Aspartame intake exacerbates asthma-related immunological, microbial, and histological disturbances. CI - (c) 2026. The Author(s). FAU - Utami, Fasty Arum AU - Utami FA AD - School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, 110, Taiwan. AD - Department of Nutrition and Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, 55281, Indonesia. FAU - Huang, Shih-Yi AU - Huang SY AD - School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, 110, Taiwan. FAU - Liu, Yu-Hsiang AU - Liu YH AD - Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. FAU - Hsu, Jhih-Wei AU - Hsu JW AD - Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. FAU - Mazariegos, Jose Roberto Rodriguez AU - Mazariegos JRR AD - College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. AD - Faculty of Health Sciences, Rafael Landivar University, Guatemala City, 01016, Guatemala. FAU - Nguyen, Nam Nhat AU - Nguyen NN AD - Endocrinology Clinic, Hanh Phuc International Hospital, Ho Chi Minh City, 700000, Vietnam. FAU - Huang, Shiu-Wen AU - Huang SW AD - Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. AD - Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. FAU - Weng, Chih-Ming AU - Weng CM AD - School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. FAU - Chuang, Hsiao-Chi AU - Chuang HC AD - School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. FAU - Huang, Chung-Hsiung AU - Huang CH AD - Department of Food Science, National Taiwan Ocean University, Keelung, 202301, Taiwan. FAU - Tsai, Wan-Ling AU - Tsai WL AD - School of Nursing, College of Nursing, Fooyin University, Kaohsiung, 831, Taiwan. FAU - Chen, Yang-Ching AU - Chen YC AD - School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. AD - Department of Family Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. AD - Department of Family Medicine, Wan Fang Hospital, Taipei Medical University, Taipei, 11696, Taiwan. melisa26@tmu.edu.tw. AD - Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. AD - Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. AD - Nutrition Research Center, Taipei Medical University Hospital, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. AD - TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. AD - Child Development Research Center, Taipei Medical University Hospital, Taipei, 110, Taiwan. melisa26@tmu.edu.tw. LA - eng GR - 113-2628-B-038-006-MY3/National Science and Technology Council/ GR - 112TMU-TMUH-02-1 and 113TMU-TMUH-01/Taipei Medical University Hospital/ PT - Journal Article DEP - 20260717 PL - England TA - Respir Res JT - Respiratory research JID - 101090633 RN - Z0H242BBR1 (Aspartame) RN - 0 (Sweetening Agents) SB - IM MH - Animals MH - *Asthma/immunology/chemically induced/epidemiology/metabolism MH - Humans MH - *Aspartame/administration & dosage/adverse effects MH - Adolescent MH - Male MH - Female MH - Mice, Inbred BALB C MH - Mice MH - Longitudinal Studies MH - Taiwan/epidemiology MH - *Lung/drug effects/immunology/metabolism MH - *Sweetening Agents/administration & dosage/adverse effects MH - Dose-Response Relationship, Drug PMC - PMC13656438 OTO - NOTNLM OT - Airway Inflammation OT - Aspartame OT - Asthma OT - Microbiota OT - Non-nutritive Sweeteners OT - Short-chain fatty acids COIS- Declarations. Ethics approval and consent to participate: The human study protocol was approved by the Institutional Review Board of Taipei Medical University (N202203060) and conducted according to the Declaration of Helsinki. Written informed consent was obtained from both parents/guardians and participating children. Animal procedures were approved by the Taipei Medical University IACUC (LAC2022-0241, LAC2023-0236) and complied with institutional and international animal care guidelines. Consent for publication: Written informed consent for publication of the study data, including any potentially identifiable information, was obtained from all participating children and their parents or legal guardians. Competing interests: The authors declare no competing interests. EDAT- 2026/07/17 06:44 MHDA- 2026/10/12 05:32 PMCR- 2026/07/17 CRDT- 2026/07/17 00:51 PHST- 2025/10/30 00:00 [received] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/10/12 05:32 [medline] PHST- 2026/07/17 06:44 [pubmed] PHST- 2026/07/17 00:51 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - 10.1186/s12931-026-03820-1 [pii] AID - 3820 [pii] AID - 10.1186/s12931-026-03820-1 [doi] PST - epublish SO - Respir Res. 2026 Jul 17;27(1):393. doi: 10.1186/s12931-026-03820-1. PMID- 42464168 OWN - NLM STAT- MEDLINE DCOM- 20260929 LR - 20260930 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jul 16 TI - Differences in fetal soft tissue thickness between GDM and non-GDM pregnancies and an exploratory nomogram for LGA prediction. LID - 10.1186/s12884-026-09665-2 [doi] LID - 1073 AB - BACKGROUND: This study aimed to compare fetal soft tissue thickness, particularly anterior abdominal wall thickness (AAWT), between GDM and non-GDM pregnancies, and to preliminarily explore its association with LGA as a secondary analysis. METHODS: A retrospective analysis was conducted on 250 pregnant women who underwent regular prenatal examinations at our hospital from January 2021 to February 2022, consisting of 125 cases in the GDM group and 125 in the non-GDM group. Ultrasound measurements of conventional fetal biometric parameters (biparietal diameter [BPD], head circumference [HC], abdominal circumference [AC], and femur length [FL]) and AAWT, fetal thigh soft tissue thickness [FTSTT], thigh muscle thickness [TM], and thigh fat thickness [TF]) were performed at 24-26, 30-32, and 36-38 weeks of gestation. Differences between the two groups were compared. Correlations between each indicator and birth weight were analyzed, along with their individual predictive efficacy for LGA. Predictor variables were selected using univariate and multivariate logistic regression as well as LASSO regression to construct an LGA risk prediction model. Its performance was compared with a estimated fetal weight (EFW) prediction model. Finally, a nomogram was developed for visual prediction. RESULTS: Maternal age, pre-pregnancy BMI, and neonatal birth weight were significantly higher in the GDM group than in the non-GDM group (P < 0.05). Fetal AAWT was also significantly greater in the GDM group across all measured gestational periods (P < 0.05). In LGA fetuses, AAWT and AC, and other parameters were significantly larger than in non-LGA fetuses at all gestational weeks (P < 0.05). Among all indicators, AAWT exhibited the strongest correlation with birth weight, and this correlation strengthened with advancing gestation (r = 0.666 at 36-38 weeks). ROC curve analysis showed that AAWT at 36-38 weeks had the highest predictive efficacy for LGA (AUC = 0.940). The multivariate logistic regression model identified AAWT at 30-32 weeks, AAWT at 36-38 weeks, and AC as independent predictors of LGA. The logistic regression model constructed based on these factors demonstrated good predictive performance (AUC = 0.966) and outperformed the EFW prediction model. Based on this model, a clinically practical nomogram was subsequently established. CONCLUSIONS: Fetal AAWT is significantly greater in GDM pregnancies than in non-GDM pregnancies and is strongly associated with LGA. A preliminary exploratory model incorporating AAWT and AC demonstrated potential utility in identifying LGA, but these findings require validation in larger, LGA-enriched cohorts. The nomogram should be considered hypothesis-generating rather than ready for clinical implementation. CI - (c) 2026. The Author(s). FAU - Zeng, Qiaoli AU - Zeng Q AD - Department of Internal Medicine, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. AD - Key Laboratory of Research in Maternal and Child Medicine and Birth Defects, Guangdong Medical University, Foshan, Guangdong, China. AD - Maternal and Child Research Institute, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. FAU - Hu, Chunyan AU - Hu C AD - Department of Ultrasound, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. FAU - Liang, Yuqiao AU - Liang Y AD - Department of Ultrasound, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. FAU - Liu, Jiaxin AU - Liu J AD - Department of Ultrasound, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. FAU - Chen, Yixing AU - Chen Y AD - Department of Ultrasound, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. FAU - Zhao, Dan AU - Zhao D AD - Department of Obstetrics and Gynecology, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. FAU - Wei, Yue AU - Wei Y AD - Department of Ultrasound, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. weiyue138@163.com. FAU - Guo, Runmin AU - Guo R AD - Department of Internal Medicine, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. runmin.guo@gdmu.edu.cn. AD - Key Laboratory of Research in Maternal and Child Medicine and Birth Defects, Guangdong Medical University, Foshan, Guangdong, China. runmin.guo@gdmu.edu.cn. AD - Maternal and Child Research Institute, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, Guangdong, China. runmin.guo@gdmu.edu.cn. LA - eng GR - 2520001002619/Self-financing science and technology project of Foshan/ GR - 2420001004539/Self-financing science and technology project of Foshan/ PT - Journal Article DEP - 20260716 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Nomograms MH - Retrospective Studies MH - Infant, Large for Gestational Age MH - Ultrasonography, Prenatal MH - Adult MH - *Diabetes, Gestational MH - *Abdominal Wall/diagnostic imaging/embryology MH - *Fetus/diagnostic imaging MH - *Fetal Macrosomia MH - Fetal Weight PMC - PMC13617886 OTO - NOTNLM OT - Fetal Anterior Abdominal Wall Thickness OT - Gestational Diabetes Mellitus OT - Large for Gestational Age OT - Logistic Regression Model OT - Nomogram OT - Ultrasonography COIS- Declarations. Ethics approval and consent to participate: The studies involving humans were approved by Ethics Committee of Shunde Women and Children's Hospital of Guangdong Medical University (Maternity and Child Healthcare Hospital of Shunde Foshan) (KY-2025-071-1); in accordance with the Declaration of Helsinki. Written informed consent was obtained from all participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/17 06:44 MHDA- 2026/09/29 06:25 PMCR- 2026/07/16 CRDT- 2026/07/17 00:47 PHST- 2026/01/28 00:00 [received] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/09/29 06:25 [medline] PHST- 2026/07/17 06:44 [pubmed] PHST- 2026/07/17 00:47 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - 10.1186/s12884-026-09665-2 [pii] AID - 9665 [pii] AID - 10.1186/s12884-026-09665-2 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jul 16;26(1):1073. doi: 10.1186/s12884-026-09665-2. PMID- 42463960 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260717 LR - 20260926 IS - 2731-4251 (Electronic) IS - 2731-4251 (Linking) VI - 5 IP - 1 DP - 2026 Jul 16 TI - Mendelian randomization of risk factors for premenstrual disorders. LID - 10.1038/s44184-026-00231-4 [doi] LID - 35 AB - The causal role of established risk factors for premenstrual disorders (PMDs) remains unclear. We used Mendelian randomization (MR) to assess causality for eight known-risk factors identified through a literature review. Summary statistics for these risk factors were from genome-wide association studies (GWAS) with sample size ranging from 129,017 to 1.2 million, and for PMDs from a GWAS of 72,297 participants. Findings were validated using one-sample MR in LifeGene cohort (n = 5674-5937). In two-sample MR, genetic liability to smoking initiation (OR = 1.25 (1.10-1.43)), earlier menarche (OR = 0.94 (0.89-0.98) per year), and higher BMI (OR = 1.19 (1.05-1.34) per kg/m(2)) were associated with PMD risk. No causal association was indicated for anemia, childhood abuse, childhood asthma, diabetes, and endometriosis. In one-sample MR, point estimates for BMI (OR = 1.10 (0.88-1.38) per kg/m(2)) and earlier menarche (OR = 0.98 (0.83-1.15) per year) were directionally consistent with the two-sample MR findings, but the confidence intervals included null effects. However, a null association was observed for smoking (OR = 0.94 (0.77-1.16)). The two-sample MR supports causal role of earlier menarche, higher BMI, and smoking in risk of PMDs. The lack of replication in one-sample MR highlights the need for triangulating evidence from future well-powered and methodologically comparable studies to strengthen these findings. CI - (c) 2026. The Author(s). FAU - Yang, Yihui AU - Yang Y AD - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. yihui.yang.2@ki.se. FAU - Tang, Bowen AU - Tang B AD - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. FAU - Hysaj, Elgeta AU - Hysaj E AD - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. FAU - Xiang, Nanyan AU - Xiang N AD - Health Management Center, General Practice Medical Center, Lab of Health Data Science, Innovation Institute for Integration of Medicine and Engineering, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Qu, Susu AU - Qu S AD - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. FAU - Hagg, Sara AU - Hagg S AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Valdimarsdottir, Unnur A AU - Valdimarsdottir UA AD - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. AD - Center of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland. AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. FAU - Bertone-Johnson, Elizabeth AU - Bertone-Johnson E AD - Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA. AD - Department of Health Promotion and Policy, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA. FAU - Lu, Yi AU - Lu Y AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Lu, Donghao AU - Lu D AD - Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. donghao.lu@ki.se. LA - eng PT - Journal Article DEP - 20260716 PL - England TA - Npj Ment Health Res JT - Npj mental health research JID - 9918592488906676 PMC - PMC13376395 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/07/17 04:03 MHDA- 2026/07/17 04:04 PMCR- 2026/07/16 CRDT- 2026/07/16 23:48 PHST- 2026/02/23 00:00 [received] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/07/17 04:04 [medline] PHST- 2026/07/17 04:03 [pubmed] PHST- 2026/07/16 23:48 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - 10.1038/s44184-026-00231-4 [pii] AID - 231 [pii] AID - 10.1038/s44184-026-00231-4 [doi] PST - epublish SO - Npj Ment Health Res. 2026 Jul 16;5(1):35. doi: 10.1038/s44184-026-00231-4. PMID- 42463441 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1096-9888 (Electronic) IS - 1076-5174 (Print) IS - 1076-5174 (Linking) VI - 61 IP - 8 DP - 2026 Aug TI - Green and Rapid Determination of Phthalates in Mineral Water From Virgin and Recycled PET Bottles. PG - e70089 LID - 10.1002/jms.70089 [doi] LID - e70089 AB - This study investigates the presence and quantification of phthalates released into mineral waters from virgin and recycled polyethylene terephthalate (PET) bottles. A green, solvent-free analytical method based on solid-phase microextraction (SPME) coupled with gas chromatography-mass spectrometry (GC/MS) was developed and validated to detect the following four target phthalates: diethyl phthalate (DEP), diisobutyl phthalate (DiBP), dibutyl phthalate (DBP), and bis(2-ethylhexyl) phthalate (DEHP). The analytical method showed good sensitivity, precision, accuracy, and low limits of detection and quantification. Seventeen commercial water samples were analyzed, including 11 from virgin PET and six from recycled PET bottles with varying recycling content (30%-100%). Phthalate concentrations ranged from 2.21 to 18.96 mug/L, with DEHP being the most prevalent compound. Risk assessment following EFSA guidelines demonstrated that the estimated daily intakes (DIs) and the risk quotient (RQ) of all detected phthalates were well below the tolerable DI limits for both adults and toddlers. These findings confirm that the proposed method is suitable for routine screening of phthalates in mineral water and highlight the need for stricter quality controls in the recycled PET supply chain. CI - (c) 2026 The Author(s). Journal of Mass Spectrometry published by John Wiley & Sons Ltd. FAU - Lino, Claudia AU - Lino C AUID- ORCID: 0000-0002-8724-7772 AD - Department of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, Palermo, Italy. FAU - Indelicato, Serena AU - Indelicato S AD - Department of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, Palermo, Italy. FAU - Bongiorno, David AU - Bongiorno D AUID- ORCID: 0000-0002-9856-356X AD - Department of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, Palermo, Italy. FAU - D'Agostino, Fabio AU - D'Agostino F AD - Institute of Anthropic Impacts and Sustainability in the Marine Environment (IAS), National Research Council of Italy (IAS-CNR), Trapani, Italy. FAU - Avellone, Giuseppe AU - Avellone G AD - Department of Biological, Chemical and Pharmaceutical Science and Technology (STEBICEF), University of Palermo, Palermo, Italy. LA - eng GR - Budget 10% dottorato 2025 University of Palermo/ PT - Journal Article PL - England TA - J Mass Spectrom JT - Journal of mass spectrometry : JMS JID - 9504818 RN - 0 (Phthalic Acids) RN - 0 (Polyethylene Terephthalates) RN - 0 (Mineral Waters) RN - 0 (Water Pollutants, Chemical) SB - IM MH - *Phthalic Acids/analysis MH - *Polyethylene Terephthalates/chemistry MH - Gas Chromatography-Mass Spectrometry/methods MH - *Mineral Waters/analysis MH - *Water Pollutants, Chemical/analysis MH - Solid Phase Microextraction/methods MH - Limit of Detection MH - Reproducibility of Results MH - Recycling MH - Green Chemistry Technology/methods MH - Food Packaging PMC - PMC13375600 OTO - NOTNLM OT - PET bottles OT - SPME-GC/MS OT - phthalates OT - water EDAT- 2026/07/17 04:03 MHDA- 2026/07/17 19:17 PMCR- 2026/07/17 CRDT- 2026/07/16 22:03 PHST- 2026/03/15 00:00 [revised] PHST- 2025/06/15 00:00 [received] PHST- 2026/07/03 00:00 [accepted] PHST- 2026/07/17 19:17 [medline] PHST- 2026/07/17 04:03 [pubmed] PHST- 2026/07/16 22:03 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - JMS70089 [pii] AID - 10.1002/jms.70089 [doi] PST - ppublish SO - J Mass Spectrom. 2026 Aug;61(8):e70089. doi: 10.1002/jms.70089. PMID- 42462817 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260923 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 124 IP - 3 DP - 2026 Sep TI - Metabolites co-correlating with maternal obesity and gestational weight gain and offspring childhood obesity: a prospective birth cohort study. PG - 101437 LID - S0002-9165(26)00246-7 [pii] LID - 10.1016/j.ajcnut.2026.101437 [doi] AB - BACKGROUND: Elevated prepregnancy body mass index (ppBMI) and excessive gestational weight gain (GWG) may contribute to the development of childhood overweight or obesity (COWO), potentially by altering the intrauterine metabolic environment. OBJECTIVES: This study aimed to evaluate the impact of maternal obesity phenotypes on maternal and umbilical cord blood metabolomic profiles, both individually and collectively, and to further examine their association with COWO incidence from preschool through adolescence. METHODS: We analyzed 1253 mother-child dyads with maternal metabolomic data collected 1 to 3 d postpartum and 856 dyads with cord metabolomic data from a prospective multiethnic birth cohort. Metabolomics was profiled using liquid chromatography-tandem mass spectrometry. COWO was defined as a BMI >/= 85th percentile for a specific age and sex. Metabolomic signatures of maternal obesity and scores were derived using linear regression and elastic net regression, and their associations with COWO were assessed via logistic regression. RESULTS: Most maternal metabolites were significantly correlated with corresponding cord metabolites (Spearman's rho: 0.11-0.67; adjusted P < 0.05), except for steroids and certain phospholipids. ppBMI was significantly associated with broad-based alterations in maternal metabolite profiles, particularly medium-chain acylcarnitines, saturated sphingomyelins, triacylglycerols, and phospholipids carrying PUFAs. We further developed ppBMI-related multi-metabolite scores (Pearson's r = 0.43-0.64) that were associated with higher birthweight (beta = 0.07-0.11; P < 0.013) and increased COWO risk (odds ratio: 1.18-1.61; all P < 0.05) from preschool through adolescence. A similar pattern was observed for GWG. In mediation analyses, the maternal metabolite score explained 12.3% (95% confidence interval: 2.18, 24.5; P = 0.02) of the association between ppBMI and BMI z-score at the last well-child visit. CONCLUSIONS: Metabolomic profiles are associated with and may partly mediate the association between maternal obesity, particularly ppBMI, and an increased risk of COWO. These findings warrant validation in independent cohorts. CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Yun, Huan AU - Yun H AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Meir, Anat Yaskolka AU - Meir AY AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Hu, Jie AU - Hu J AD - Epidemiology and Center for Genomic Medicine and Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States. FAU - Wang, Guoying AU - Wang G AD - Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, John Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States. FAU - Hu, Frank B AU - Hu FB AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States. FAU - Hong, Xiumei AU - Hong X AD - Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, John Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States. FAU - Wang, Xiaobin AU - Wang X AD - Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, John Hopkins University Bloomberg School of Public Health, Baltimore, MD, United States; Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, United States. FAU - Liang, Liming AU - Liang L AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, United States; Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, United States. Electronic address: lliang@hsph.harvard.edu. LA - eng GR - R01 ES031521/ES/NIEHS NIH HHS/United States GR - R21 AI171059/AI/NIAID NIH HHS/United States GR - R01 ES031272/ES/NIEHS NIH HHS/United States GR - R21 HD116039/HD/NICHD NIH HHS/United States GR - U01 ES034983/ES/NIEHS NIH HHS/United States GR - R01 HD041702/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20260716 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Gestational Weight Gain MH - Prospective Studies MH - Child, Preschool MH - *Pediatric Obesity/etiology/metabolism/epidemiology MH - Birth Cohort MH - Child MH - Body Mass Index MH - *Pregnancy in Obesity/metabolism MH - Male MH - Fetal Blood/metabolism MH - Adult MH - Adolescent MH - *Metabolome MH - Metabolomics MH - Developmental Origins of Health and Disease MH - *Obesity PMC - PMC13390791 MID - NIHMS2196151 OTO - NOTNLM OT - birth cohort OT - childhood overweight or obesity OT - gestational weight gain OT - metabolome OT - prepregnancy BMI COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/07/17 00:42 MHDA- 2026/09/01 23:34 PMCR- 2026/07/23 CRDT- 2026/07/16 19:11 PHST- 2026/01/22 00:00 [received] PHST- 2026/07/10 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/09/01 23:34 [medline] PHST- 2026/07/17 00:42 [pubmed] PHST- 2026/07/16 19:11 [entrez] PHST- 2026/07/23 00:00 [pmc-release] AID - S0002-9165(26)00246-7 [pii] AID - 10.1016/j.ajcnut.2026.101437 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Sep;124(3):101437. doi: 10.1016/j.ajcnut.2026.101437. Epub 2026 Jul 16. PMID- 42462582 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260831 IS - 1872-8464 (Electronic) IS - 0165-5876 (Linking) VI - 208 DP - 2026 Sep TI - Evaluation of anatomical and ultrasonographic parameters to predict difficult airway in pediatric patients. PG - 112932 LID - S0165-5876(26)00228-4 [pii] LID - 10.1016/j.ijporl.2026.112932 [doi] AB - BACKGROUND: Predicting a difficult airway in pediatric patients remains challenging due to unique anatomical and physiological characteristics. Traditional bedside predictors show inconsistent accuracy in children, and ultrasonography has emerged as a promising, objective tool for airway evaluation. This study aimed to assess the diagnostic performance of anatomical and ultrasonographic parameters in predicting difficult intubation in pediatric patients. METHODS: In this prospective, double-blind observational study, children aged 1-12 years undergoing elective surgery with endotracheal intubation were evaluated. Clinical assessments included anthropometric measurements and airway tests (Mallampati, thyromental distance (TMD), sternomental distance (SMD), hyomental distance (HMD)). Sonographic measurements-skin-epiglottis distance (S-ED) and skin-hyoid distance (S-HD)-were obtained preoperatively. Difficult intubation was defined as Intubation Difficulty Score (IDS) > 5. ROC curve analyses were used to evaluate diagnostic performance; logistic regression identified independent predictors. RESULTS: A total of 240 children were included, with a difficult-intubation incidence of 20%. S-ED demonstrated the highest predictive accuracy (AUC 0.941), followed by S-HD (AUC 0.912), HMD (AUC 0.898), and Mallampati classification (AUC 0.860). TMD and SMD showed moderate predictive ability. Combining significant clinical and sonographic parameters improved diagnostic performance, with S-ED + S-HD yielding an AUC of 0.961. Multivariable regression identified S-ED (OR 4.61), S-HD (OR 1.76), Mallampati >/= III, and facial anomalies as independent predictors of difficult intubation. The final model correctly classified 95.4% of cases. CONCLUSIONS: Ultrasonographic parameters, particularly S-ED and S-HD, are highly accurate predictors of difficult intubation in children and outperform traditional clinical tests. Combining sonographic with anatomical assessments significantly enhances diagnostic performance. Airway ultrasound provides an objective, reproducible, and non-cooperation-dependent tool that can improve preoperative risk stratification in pediatric anesthesia. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Altun, Demet AU - Altun D AD - Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey. Electronic address: drdemetaltun@hotmail.com. FAU - Canbaz, Mert AU - Canbaz M AD - Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey. FAU - Dincer, Muserref Beril AU - Dincer MB AD - Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey. FAU - Demirel, Ebru Emre AU - Demirel EE AD - Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey. FAU - Altun, Dilek AU - Altun D AD - Acibadem Mehmet Ali Aydinlar University, Department of Anesthesiology and Reanimation, Istanbul, Turkey. FAU - Kara, Hakan AU - Kara H AD - Istanbul Faculty of Medicine, Department of Otolaryngology & Head and Neck Surgery, Istanbul, Turkey. FAU - Sivrikoz, Nukhet AU - Sivrikoz N AD - Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey. FAU - Camci, Emre AU - Camci E AD - Istanbul University, Istanbul Faculty of Medicine, Department of Anesthesiology, Istanbul, Turkey. LA - eng PT - Journal Article PT - Observational Study DEP - 20260716 PL - Ireland TA - Int J Pediatr Otorhinolaryngol JT - International journal of pediatric otorhinolaryngology JID - 8003603 SB - IM MH - Humans MH - Child, Preschool MH - Female MH - Male MH - Child MH - Prospective Studies MH - *Intubation, Intratracheal/methods/adverse effects MH - Infant MH - Ultrasonography MH - Double-Blind Method MH - Predictive Value of Tests MH - ROC Curve MH - Elective Surgical Procedures/methods MH - Pediatric Anesthesia MH - *Airway Management/methods OTO - NOTNLM OT - Airway assessment OT - Difficult airway OT - Pediatric anesthesia OT - Pediatric intubation OT - Skin-epiglottis distance OT - Ultrasonography COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/17 04:03 MHDA- 2026/08/18 23:36 CRDT- 2026/07/16 18:08 PHST- 2026/06/02 00:00 [received] PHST- 2026/07/10 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/18 23:36 [medline] PHST- 2026/07/17 04:03 [pubmed] PHST- 2026/07/16 18:08 [entrez] AID - S0165-5876(26)00228-4 [pii] AID - 10.1016/j.ijporl.2026.112932 [doi] PST - ppublish SO - Int J Pediatr Otorhinolaryngol. 2026 Sep;208:112932. doi: 10.1016/j.ijporl.2026.112932. Epub 2026 Jul 16. PMID- 42462323 OWN - NLM STAT- MEDLINE DCOM- 20260810 LR - 20260810 IS - 1878-5506 (Electronic) IS - 1389-9457 (Linking) VI - 147 DP - 2026 Nov TI - Sleep patterns and determinants of sleep disturbances in preschool children in the CoAlHaS cohort. PG - 109143 LID - S1389-9457(26)00382-5 [pii] LID - 10.1016/j.sleep.2026.109143 [doi] AB - INTRODUCTION: Sleep disturbances represent a significant public health concern from early childhood, given the long-term implications for health and development. This study examined sleep patterns and factors associated with sleep disturbances in preschool-aged children. METHODS: Data were collected from 1287 participants (544 born in 2018 and 743 born in 2020/21) within the CoAlHaS cohort (Cantabria, Spain). Baseline information was obtained at birth, with follow-up data collected through face-to-face visits, including parent interviews, anthropometric measurements and linkage to medical records. Sleep patterns and disturbances were assessed by the Spanish version of the Children's Sleep Habits Questionnaire (CSHQ-SP). Children were classified as 'poor sleepers' using the validated Spanish threshold of 50.35 points. Associations with perinatal, lifestyle and sociodemographic factors were analysed using one-way ANOVA, independent-samples t-tests and multivariable logistic regression. RESULTS: The prevalence of sleep problems was 36.22% in the total sample. Recommended sleep duration was generally met, although patterns varied between cohorts. Globally, prematurity (OR 2.10, 95% CI 1.24-3.56), increased screen time exposure (OR 1.06, 95% CI 1.01-1.10) and late bedtimes (OR 1.46, 95% CI 0.99-2.13) were linked to being a poor sleeper, whereas higher maternal educational attainment (OR 0.62, 95% CI 0.40-0.96) and younger age (OR 0.24, 95% CI 0.07-0.77) were associated with reduced odds. CONCLUSION: Sleep disturbances are frequent among early childhood, despite achieving recommended sleep duration. Early identification of children at risk and targeted interventions focusing on sleep routines and modifiable family-level factors could be essential to improve sleep habits. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Sanchez-Piorno, L AU - Sanchez-Piorno L AD - Preventive Medicine Group, University of Cantabria, IDIVAL-Valdecilla Health Research Institute, Santander, Spain. FAU - Gomez-Acebo, I AU - Gomez-Acebo I AD - Preventive Medicine Group, University of Cantabria, IDIVAL-Valdecilla Health Research Institute, Santander, Spain; CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain. FAU - Alonso-Molero, J AU - Alonso-Molero J AD - Preventive Medicine Group, University of Cantabria, IDIVAL-Valdecilla Health Research Institute, Santander, Spain; CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain. FAU - Valero-Dominguez, S AU - Valero-Dominguez S AD - Preventive Medicine Group, University of Cantabria, IDIVAL-Valdecilla Health Research Institute, Santander, Spain; RICORS Node - Carlos III Health Institute, Madrid, Spain. FAU - Llorente-Pelayo, S AU - Llorente-Pelayo S AD - Department of Pediatrics, Marques de Valdecilla University Hospital, IDIVAL-Valdecilla Health Research Institute, Santander, Spain. FAU - Lechosa-Muniz, C AU - Lechosa-Muniz C AD - RICORS Node - Carlos III Health Institute, Madrid, Spain; Department of Pediatrics, Marques de Valdecilla University Hospital, IDIVAL-Valdecilla Health Research Institute, Santander, Spain. FAU - Cabero-Perez, M AU - Cabero-Perez M AD - RICORS Node - Carlos III Health Institute, Madrid, Spain; Department of Pediatrics, Marques de Valdecilla University Hospital, IDIVAL-Valdecilla Health Research Institute, Santander, Spain. FAU - Dierssen-Sotos, T AU - Dierssen-Sotos T AD - Preventive Medicine Group, University of Cantabria, IDIVAL-Valdecilla Health Research Institute, Santander, Spain; CIBER Epidemiology and Public Health (CIBERESP), Madrid, Spain. Electronic address: trinidad.dierssen@unican.es. LA - eng PT - Journal Article DEP - 20260715 PL - Netherlands TA - Sleep Med JT - Sleep medicine JID - 100898759 SB - IM MH - Humans MH - Child, Preschool MH - Female MH - *Sleep Wake Disorders/epidemiology MH - Male MH - Surveys and Questionnaires MH - Prevalence MH - Spain/epidemiology MH - Sleep Duration MH - Cohort Studies MH - *Sleep/physiology MH - Risk Factors OTO - NOTNLM OT - Child OT - Preschool OT - Preterm birth OT - Screen time OT - Sleep wake disorders OT - Socioeconomic factors COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/16 22:01 MHDA- 2026/08/11 00:35 CRDT- 2026/07/16 18:00 PHST- 2026/03/12 00:00 [received] PHST- 2026/07/14 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/08/11 00:35 [medline] PHST- 2026/07/16 22:01 [pubmed] PHST- 2026/07/16 18:00 [entrez] AID - S1389-9457(26)00382-5 [pii] AID - 10.1016/j.sleep.2026.109143 [doi] PST - ppublish SO - Sleep Med. 2026 Nov;147:109143. doi: 10.1016/j.sleep.2026.109143. Epub 2026 Jul 15. PMID- 42462275 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260905 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Jul 16 TI - Physical Activity Monitoring Using Wearable Devices in Young Adults: Secondary Analysis of a 6-Month Motivational Interviewing Pilot Randomized Controlled Trial. PG - e94673 LID - 10.2196/94673 [doi] LID - e94673 AB - In this secondary analysis of a pilot randomized controlled trial of university students aged 18 to 29 years, we assessed the feasibility of providing wearable devices to measure physical activity over 6 months, finding that daily adherence declined over time in both groups, while moderate and vigorous physical activity levels remained similar between the control and intervention groups. CI - (c) Nicolette Christodoulakis, Taylor Incze, Sahar Khademioore, Matthew Kwan, Elizabeth Alvarez, Jean-Eric Tarride, Lawrence Mbuagbaw, Laura N Anderson. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Christodoulakis, Nicolette AU - Christodoulakis N AUID- ORCID: 0000-0001-7852-139X AD - Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada, 1 (905) 525-9140. FAU - Incze, Taylor AU - Incze T AUID- ORCID: 0000-0003-4076-8578 AD - Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada, 1 (905) 525-9140. FAU - Khademioore, Sahar AU - Khademioore S AUID- ORCID: 0000-0002-3025-0006 AD - Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada, 1 (905) 525-9140. FAU - Kwan, Matthew AU - Kwan M AUID- ORCID: 0000-0002-9757-2771 AD - Department of Child and Youth Studies, Brock University, St. Catharines, ON, Canada. AD - Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada. AD - School of Human Movement and Nutrition Science, The University of Queensland, Brisbane, Queensland, Australia. FAU - Alvarez, Elizabeth AU - Alvarez E AUID- ORCID: 0000-0003-2333-0144 AD - Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada, 1 (905) 525-9140. AD - Centre for Health Economics and Policy Analysis (CHEPA), McMaster University, Hamilton, ON, Canada. FAU - Tarride, Jean-Eric AU - Tarride JE AUID- ORCID: 0000-0003-2913-7580 AD - Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada, 1 (905) 525-9140. AD - Centre for Health Economics and Policy Analysis (CHEPA), McMaster University, Hamilton, ON, Canada. AD - Programs for Assessment of Technology in Health (PATH), The Research Institute of St. Joe's Hamilton, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada. FAU - Mbuagbaw, Lawrence AU - Mbuagbaw L AUID- ORCID: 0000-0001-5855-5461 AD - Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada, 1 (905) 525-9140. AD - Biostatistics Unit, Father Sean O'Sullivan Research Centre, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada. AD - Department of Anesthesia, McMaster University, Hamilton, ON, Canada. AD - Department of Pediatrics, McMaster University, Hamilton, ON, Canada. AD - Centre for Development of Best Practices in Health, Yaounde Central Hospital, Yaounde, Cameroon. AD - Division of Epidemiology and Biostatistics, Department of Global Health, Stellenbosch University, Cape Town, Western Cape, South Africa. FAU - Anderson, Laura N AU - Anderson LN AUID- ORCID: 0000-0002-6106-5073 AD - Department of Health Research Methods, Evidence, and Impact, McMaster University, 1280 Main Street West, Hamilton, ON, L8S 4K1, Canada, 1 (905) 525-9140. AD - Centre for Health Economics and Policy Analysis (CHEPA), McMaster University, Hamilton, ON, Canada. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20260716 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - *Exercise/psychology MH - *Motivational Interviewing/methods MH - Pilot Projects MH - *Wearable Electronic Devices/standards MH - Secondary Data Analysis PMC - PMC13375207 OTO - NOTNLM OT - exercise OT - fitness trackers OT - motivational interviewing OT - pilot study OT - wearable electronic devices OT - young adult COIS- Conflicts of Interest: None declared. EDAT- 2026/07/16 22:01 MHDA- 2026/07/17 19:17 PMCR- 2026/07/16 CRDT- 2026/07/16 17:43 PHST- 2026/03/04 00:00 [received] PHST- 2026/05/16 00:00 [revised] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/07/17 19:17 [medline] PHST- 2026/07/16 22:01 [pubmed] PHST- 2026/07/16 17:43 [entrez] PHST- 2026/07/16 00:00 [pmc-release] AID - v10i1e94673 [pii] AID - 94673 [pii] AID - 10.2196/94673 [doi] PST - epublish SO - JMIR Form Res. 2026 Jul 16;10:e94673. doi: 10.2196/94673. PMID- 42461751 OWN - NLM STAT- Publisher LR - 20260803 IS - 1537-1603 (Electronic) IS - 0736-0258 (Linking) DP - 2026 Jul 16 TI - Peripheral Nerve Cross-Sectional Area in Healthy Thai Children: Reference Values for Clinical Neuromuscular Ultrasound. LID - 10.1097/WNP.0000000000001284 [doi] AB - INTRODUCTION: Ultrasonography of the nerve cross-sectional area (CSA) is increasingly used to support the diagnosis of peripheral neuropathies. However, normative CSA reference values in children, particularly in Southeast Asian populations, are limited. METHODS: Ultrasonographic nerve CSA measurements were conducted in 164 healthy Thai children aged 1 to 18 years at King Chulalongkorn Memorial Hospital, Thailand. Participants were classified into six age groups. CSA was measured in 10 peripheral nerves at 34 anatomical sites and bilateral cervical roots (C5-C7), and the median CSAs were calculated. Correlations between CSA and body weight, height, and age were calculated using Spearman and Pearson correlation coefficients. Intraobserver and interobserver reliability were evaluated in a subset of participants using intraclass correlation coefficients. RESULTS: Normative CSA values were established for all examined nerves and sites. Most nerves demonstrated proximal-to-distal tapering in CSA, with the median nerve exhibiting a unique pattern of larger CSA at the wrist and mid-upper arm. C7 root was the largest cervical root measured (median CSA up to 7.0 mm 2 in older adolescents). CSA demonstrated moderate-to-strong correlations with anthropometric variables, including weight, height, and age ( r = 0.36-0.78). The tibial, sciatic, and median nerves showed the strongest correlations (all P < 0.001). Intraobserver and interobserver reliability were good-to-excellent across the selected nerves. CONCLUSIONS: Nerve CSA is influenced by age, weight, height, and location in this Southeast Asian population. These normative reference values may serve as a reference for distinguishing normal from pathological findings and aid clinical decision making in pediatric neurophysiological practice. CI - Copyright (c) 2026 by the American Clinical Neurophysiology Society. FAU - Paprad, Tanitnun AU - Paprad T AD - Division of Neurology, Department of Pediatrics, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. AD - Department of Pediatrics, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. FAU - Amornvit, Jakkrit AU - Amornvit J AD - Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. AD - Division of Neurology, Department of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. FAU - Stonsaovapak, Chernkhuan AU - Stonsaovapak C AD - Department of Rehabilitation Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. FAU - Naothaworn, Kamin AU - Naothaworn K AD - Neuroscience Center, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. FAU - Pasutharnchat, Nath AU - Pasutharnchat N AD - Division of Neurology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. AD - Division of Neurology, Department of Medicine, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. FAU - Paprad, Tunchanok AU - Paprad T AUID- ORCID: 0000-0002-5281-8248 AD - Department of Radiology, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand; and. AD - Chulalongkorn International Medical Program, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand. LA - eng GR - 66/020/Ratchadapiseksompotch fund, Chulalongkorn University/ PT - Journal Article DEP - 20260716 PL - United States TA - J Clin Neurophysiol JT - Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society JID - 8506708 SB - IM OTO - NOTNLM OT - Cross-sectional area OT - Nerve ultrasound OT - Normal value OT - Pediatric CSA COIS- The authors declare no conflicts of interest. EDAT- 2026/07/16 22:01 MHDA- 2026/07/16 22:01 CRDT- 2026/07/16 12:52 PHST- 2026/07/16 22:01 [pubmed] PHST- 2026/07/16 22:01 [medline] PHST- 2026/07/16 12:52 [entrez] AID - 00004691-990000000-00332 [pii] AID - 10.1097/WNP.0000000000001284 [doi] PST - aheadofprint SO - J Clin Neurophysiol. 2026 Jul 16. doi: 10.1097/WNP.0000000000001284. PMID- 42461426 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20261008 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 30 IP - 8 DP - 2026 Jul 16 TI - Association of salivary dynamics, psychological stress, and behavioral factors with tooth wear severity: a cross-sectional study. LID - 339 [pii] LID - 10.1007/s00784-026-07029-w [doi] AB - OBJECTIVES: While the etiology of tooth wear is known to be multifactorial, data regarding the interaction between psychological profile, salivary dynamics, and clinical wear severity remain insufficiently elucidated. This study aimed to analyze the effects of psychological profile and salivary parameters-alongside demographic data, medical history, oral hygiene habits, and dietary patterns-on the severity of clinical tooth wear in a multivariable framework. MATERIALS AND METHODS: Following institutional ethical approval and informed consent, this cross-sectional study included 101 volunteers (90% power), categorized by stress severity (DASS-21: normal, mild, moderate, severe, extremely severe), age groups (18-30, 31-40, 41-50, 51-60, 61-65 years) and salivary pH/buffering capacity levels (low, intermediate, high) for intergroup comparisons. Clinical wear severity was assessed using the Smith and Knight Tooth Wear Index (TWI); psychometric profiles were evaluated via the Depression Anxiety Stress Scale-21 (DASS-21). Salivary analyses (unstimulated pH and stimulated buffering capacity) utilized the GC Saliva-Check Buffer kit. Data were analyzed using independent t-tests, one-way ANOVA, and six-block hierarchical multiple linear regression (p < 0.05). RESULTS: The mean age was 46.7 years; significant differences in TWI scores existed among five age groups (18-30, 31-40, 41-50, 51-60, and 61-65 years; p < 0.05), with the highest wear severity observed in the 61-65 age group (Mean: 2.63). Severe stress (p = 0.008), low salivary pH and insufficient buffering capacity (p = 0.001), and acidic beverage consumption without a straw (p = 0.001) were significantly associated with higher TWI scores. In hierarchical regression, salivary buffering capacity (beta = -0.289), straw use (beta = -0.248), and salivary pH (beta = -0.228) emerged as independent predictors of wear severity (R(2) = 0.519), whereas psychological variables did not contribute independently. CONCLUSIONS: These observational findings suggest that tooth wear severity is associated with the cumulative interplay of biological, behavioral, and psychological factors. Impaired salivary dynamics and specific behavioral patterns were the strongest independent correlates of wear severity; the role of psychological stress appears to operate indirectly, warranting further longitudinal investigation. CLINICAL RELEVANCE: These findings underline the potential value of considering salivary parameters and consumption-related behaviours when evaluating tooth wear risk in adults, while further longitudinal evidence is required before firm clinical recommendations can be made. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Yilmaz, Damla AU - Yilmaz D AUID- ORCID: 0009-0008-2602-877X AD - Department of Restorative Dentistry, Faculty of Dentistry, Necmettin Erbakan University, Konya, Turkiye. damlayylmz@gmail.com. FAU - Dereli, Zeynep AU - Dereli Z AUID- ORCID: 0000-0003-2317-9069 AD - Department of Restorative Dentistry, Faculty of Dentistry, Necmettin Erbakan University, Konya, Turkiye. LA - eng GR - Project No: 25DU24004/Necmettin Erbakan Universitesi/ GR - Project No: 25DU24004/Necmettin Erbakan Universitesi/ PT - Journal Article DEP - 20260716 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Middle Aged MH - Female MH - Adult MH - Male MH - *Stress, Psychological/complications MH - *Saliva/chemistry/metabolism MH - *Tooth Wear/psychology/etiology MH - Adolescent MH - Aged MH - Young Adult MH - Severity of Illness Index OTO - NOTNLM OT - Cross-sectional study OT - Hierarchical regression OT - Psychological stress OT - Salivary buffering capacity OT - Tooth wear COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Institutional Ethics Committee of Necmettin Erbakan University (Date: April 24, 2025/Decision No: 2025/580). Consent to participate: Written informed consent was obtained from all individual participants included in the study. Consent to publish: The authors affirm that human research participants provided informed consent for publication of the images in Fig. 2. Competing interests: The authors declare no competing interests. EDAT- 2026/07/16 16:06 MHDA- 2026/07/16 18:46 CRDT- 2026/07/16 11:15 PHST- 2026/03/07 00:00 [received] PHST- 2026/07/11 00:00 [accepted] PHST- 2026/07/16 18:46 [medline] PHST- 2026/07/16 16:06 [pubmed] PHST- 2026/07/16 11:15 [entrez] AID - 10.1007/s00784-026-07029-w [pii] AID - 10.1007/s00784-026-07029-w [doi] PST - epublish SO - Clin Oral Investig. 2026 Jul 16;30(8):339. doi: 10.1007/s00784-026-07029-w. PMID- 42460647 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261008 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) VI - 83 IP - 4 DP - 2026 Oct TI - The illusion of competence: Evaluating the clinical reasoning of large language models in pediatric gastroenterology. PG - 644-651 LID - 10.1002/jpn3.70502 [doi] AB - OBJECTIVE: To evaluate the diagnostic accuracy and clinical reasoning of three frontier large language models (LLMs) across standardized pediatric gastroenterology, hepatology, and nutrition (PGHN) clinical vignettes. METHODS: In this cross-sectional study, 25 fictional PGHN vignettes were developed by one board-certified pediatric gastroenterologist and evaluated using three LLMs: Gemini 3.1 Pro, ChatGPT 5.4 Thinking, and Claude Sonnet 4.6 Extended. A conditional two-step prompting protocol was applied. Three blinded, PGHN-certified co-authors independently scored responses using a structured instrument covering four domains (diagnostic accuracy, management, patient safety, reference quality; 0-2 each) and a global quality of clinical reasoning (QCR) score (1-5 Likert scale). Interobserver reliability was assessed using the intraclass correlation coefficient (ICC). Group differences were analyzed using the Kruskal-Wallis H test with Dunn post-hoc correction. RESULTS: Interobserver reliability was excellent (ICC: 0.98 for domains; 0.87 for QCR). All three models achieved perfect diagnostic accuracy (median 2.00, interquartile range: 2.00-2.00). Statistically significant intermodel differences were identified in reference quality (p = 0.048) and QCR (p = 0.049). Claude achieved significantly higher QCR scores than ChatGPT (p = 0.043) and demonstrated the highest overall reference quality. Qualitative analysis revealed critical pharmacological dosing errors, contextual blindness, temporal obsolescence, and a high frequency of fabricated citations. CONCLUSION: While current LLMs demonstrate good diagnostic pattern recognition in PGHN, reproducible and potentially life-threatening failures in pharmacological reasoning and reference accuracy create a dangerous illusion of competence. These findings suggest that LLMs may support differential diagnosis brainstorming in PGHN but do not establish their safety in real-world clinical scenarios. CI - (c) 2026 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Ergen, Yasin Maruf AU - Ergen YM AUID- ORCID: 0000-0002-3689-6852 AD - Department of Pediatrics/Division of Pediatric Gastroenterology, Gulhane Training and Research Hospital, Ankara, Turkey. FAU - Teke, Selcuk AU - Teke S AUID- ORCID: 0000-0002-1885-6611 AD - Department of Pediatrics/Division of Pediatric Gastroenterology, Gulhane Training and Research Hospital, Ankara, Turkey. FAU - Basaran, Edibe Gozde AU - Basaran EG AUID- ORCID: 0000-0003-3165-3234 AD - Department of Pediatrics/Division of Pediatric Gastroenterology, Gulhane Training and Research Hospital, Ankara, Turkey. FAU - Balamtekin, Necati AU - Balamtekin N AUID- ORCID: 0000-0001-8665-5611 AD - Department of Pediatrics/Division of Pediatric Gastroenterology, Gulhane Training and Research Hospital, Ankara, Turkey. LA - eng GR - None/ PT - Journal Article DEP - 20260716 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM MH - Humans MH - *Large Language Models MH - Cross-Sectional Studies MH - Reproducibility of Results MH - *Clinical Competence MH - *Pediatrics/standards/methods MH - *Gastroenterology/standards/methods MH - *Clinical Reasoning MH - Observer Variation MH - Child OTO - NOTNLM OT - artificial intelligence OT - clinical decision support OT - guideline concordance OT - hallucination OT - reference hallucination EDAT- 2026/07/16 16:06 MHDA- 2026/10/08 05:31 CRDT- 2026/07/16 06:42 PHST- 2026/04/19 00:00 [revised] PHST- 2026/03/26 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/10/08 05:31 [medline] PHST- 2026/07/16 16:06 [pubmed] PHST- 2026/07/16 06:42 [entrez] AID - 10.1002/jpn3.70502 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Oct;83(4):644-651. doi: 10.1002/jpn3.70502. Epub 2026 Jul 16. PMID- 42460424 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260716 LR - 20260813 IS - 2048-7177 (Print) IS - 2048-7177 (Electronic) IS - 2048-7177 (Linking) VI - 14 IP - 7 DP - 2026 Jul TI - Nutrient Contribution and Acceptability of Dried Small Indigenous Fish Powders for Complementary Feeding in Northern Cameroon. PG - e72116 LID - 10.1002/fsn3.72116 [doi] LID - e72116 AB - Child malnutrition remains a major public health concern in northern Cameroon, where limited access to animal-source foods contributes to persistent undernutrition and micronutrient deficiencies. This study investigated the nutritional composition of small indigenous fish species, documented household knowledge and consumption practices, and evaluated the acceptability of a small-fish-based complementary food. A mixed-methods design was implemented across six localities in the North and Far North regions, combining household surveys (n = 639), qualitative interviews with actors in the fish value chain, nutrient analyses of 19 fish samples, and an acceptability test among children aged 6-23 months (n = 104). Dried small fish showed high nutrient density, with 50.3-64.1 g protein, 11.2-16.7 g fat, and up to 1412 mg calcium per 100 g. A 10 g portion contributed 40%-50% of daily protein needs and up to one-third of calcium requirements for young children. Despite widespread household consumption (92.5%), only 24.6% incorporated small fish into children's meals, reflecting gaps in caregiver knowledge of complementary feeding. The standardized fish powder was well accepted, with mean of hedonic scores of 5.8 +/- 1.2 for taste, 5.6 +/- 1.3 for odor, and 5.7 +/- 1.1 for overall appreciation (p < 0.05 compared with the neutral midpoint of 4.0). Caregivers reported ease of incorporation into common child foods, indicating strong feasibility for household use. These findings demonstrate that small indigenous fish are nutrient-dense, culturally acceptable, and feasible to integrate into complementary feeding. Given the observational nature of the study, conclusions remain cautious. Future research should assess long-term nutritional impacts, evaluate product stability and safety under household storage, and explore scalable models for community-based production. CI - (c) 2026 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC. FAU - Christine, Abomo Ndzana Anne AU - Christine ANA AD - Center for Food and Nutrition Research IMPM Yaounde Cameroon. AD - School of Health Sciences Catholic University of Central Africa Yaounde Cameroon. FAU - Josette, Essa'a Veronique AU - Josette EV AD - Center for Food and Nutrition Research IMPM Yaounde Cameroon. FAU - Antoine, Socpa AU - Antoine S AD - School of Health Sciences Catholic University of Central Africa Yaounde Cameroon. AD - Department of Anthropology University of Yaounde 1 Yaounde Cameroon. FAU - Martin, Nankap AU - Martin N AD - UNICEF Yaounde Yaounde Cameroon. FAU - Gabriel, Medoua Nama AU - Gabriel MN AUID- ORCID: 0000-0002-8189-432X AD - Center for Food and Nutrition Research IMPM Yaounde Cameroon. AD - School of Health Sciences Catholic University of Central Africa Yaounde Cameroon. LA - eng PT - Journal Article DEP - 20260714 PL - United States TA - Food Sci Nutr JT - Food science & nutrition JID - 101605473 PMC - PMC13369287 OTO - NOTNLM OT - complementary feeding OT - fish powder OT - infant and young child nutrition OT - nutrient intake OT - small indigenous fish COIS- The authors declare no conflicts of interest. EDAT- 2026/07/16 06:38 MHDA- 2026/07/16 06:39 PMCR- 2026/07/14 CRDT- 2026/07/16 04:45 PHST- 2026/02/24 00:00 [received] PHST- 2026/05/19 00:00 [revised] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/07/16 06:39 [medline] PHST- 2026/07/16 06:38 [pubmed] PHST- 2026/07/16 04:45 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - FSN372116 [pii] AID - 10.1002/fsn3.72116 [doi] PST - epublish SO - Food Sci Nutr. 2026 Jul 14;14(7):e72116. doi: 10.1002/fsn3.72116. eCollection 2026 Jul. PMID- 42459815 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20261013 IS - 1432-2277 (Electronic) IS - 0934-0874 (Print) IS - 0934-0874 (Linking) VI - 39 DP - 2026 TI - Landscape of current practices and future perspectives in living donor kidney donation in Europe: proceedings of a pan-European symposium by the European kidney transplant association section of the European Society for Organ Transplantation. PG - 16548 LID - 10.3389/ti.2026.16548 [doi] LID - 16548 AB - Living donor kidney transplantation (LDKT) offers superior outcomes for most patients with end-stage kidney disease (ESKD), yet its uptake across Europe remains highly variable. This proceedings article summarizes key themes from a pan-European symposium held in November 2025 in Prague, organized by the European Kidney Transplant Association (EKITA) in collaboration with the DESCaRTES Working Group. Discussions highlighted substantial heterogeneity in LDKT activity across Europe, driven by differences in healthcare capacity, legal frameworks, donor evaluation practices, and access to kidney exchange programmes. Marked inequities persist between regions, particularly in the Balkans and Western Balkans, for women those who are socioeconomically disadvantaged, ethnic minority populations, paediatric and elderly patients and individuals with obesity. The symposium identified wide variation in donor selection criteria, risk assessment, informed consent practices, and long-term donor follow-up, despite existing international guidelines. Emerging strategies to address these challenges include harmonisation of donor evaluation and consent, expansion of paired and cross-border kidney exchange programmes, increased use of unspecified kidney donation, and adoption of innovative surgical and immunological approaches to safely broaden donor eligibility. Advances in outcome measurement, including validated surrogate endpoints, machine learning methods, and integrated, harmonised transplant registries, were discussed as critical tools to improve quality, transparency, and research efficiency. Collectively, the proceedings underscore the need for coordinated clinical, policy, and data-driven solutions to reduce inequities and unlock the full potential of LDKT across Europe, with implications for international transplant practice. CI - Copyright (c) 2026 Kousios, Baas, Manonelles, Ortiz, Rista, Thomas, Lefaucheur, Akin and Marson. FAU - Kousios, Andreas AU - Kousios A AD - School of Medicine, European University Cyprus, Nicosia, Cyprus. AD - Nefrontida Medical Centre, Nicosia, Cyprus. FAU - Baas, Marije AU - Baas M AD - Department of Nephrology, Radboud University Medical Center, Radboud Universiteit, Nijmegen, Netherlands. FAU - Manonelles, Anna AU - Manonelles A AD - Renal Transplant Unit, Nephrology Department, Bellvitge University Hospital, Barcelona, Spain. FAU - Ortiz, Fernanda AU - Ortiz F AD - Abdominal Unit, Nephrology, Helsinki University Hospital, Helsinki, Finland. FAU - Rista, Elvana AU - Rista E AD - Department of Nephrology, Dialysis, and Kidney Transplantation, Hygeia International Hospital, Tirana, Albania. FAU - Thomas, Rachel AU - Thomas R AD - Edinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom. FAU - Lefaucheur, Carmen AU - Lefaucheur C AD - Saint Louis Hospital, Assistance Publique- Hopiteux de Paris and Universite Paris Cite, Paris, France. FAU - Akin, Emin Baris AU - Akin EB AD - Department of General Surgery, Demiroglu Bilim University and Group Florence Nightingale Hospital, Istanbul, Turkiye. FAU - Marson, Lorna AU - Marson L AD - Edinburgh Transplant Centre, Royal Infirmary of Edinburgh, Edinburgh, United Kingdom. LA - eng PT - Conference Proceedings DEP - 20260701 PL - Switzerland TA - Transpl Int JT - Transplant international : official journal of the European Society for Organ Transplantation JID - 8908516 SB - IM EIN - Transpl Int. 2026 Sep 28;39:17772. doi: 10.3389/ti.2026.17772. PMID: 42866521 MH - Humans MH - *Kidney Transplantation/methods/trends MH - *Living Donors MH - Europe MH - *Kidney Failure, Chronic/surgery MH - *Tissue and Organ Procurement/trends MH - Female MH - Donor Selection MH - Informed Consent MH - Risk Assessment PMC - PMC13368691 OTO - NOTNLM OT - cross-border organ exchange OT - donor evaluation and safety OT - equity in transplantation OT - living donor kidney transplantation OT - transplant registry harmonisation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/16 06:34 MHDA- 2026/07/16 13:02 PMCR- 2026/07/01 CRDT- 2026/07/16 04:39 PHST- 2026/03/10 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/07/16 13:02 [medline] PHST- 2026/07/16 06:34 [pubmed] PHST- 2026/07/16 04:39 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 16548 [pii] AID - 10.3389/ti.2026.16548 [doi] PST - epublish SO - Transpl Int. 2026 Jul 1;39:16548. doi: 10.3389/ti.2026.16548. eCollection 2026. PMID- 42459791 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260716 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - From policy to practice: teacher capacity as the missing link in food and nutrition education reform in Tamil Nadu, India. PG - 1743897 LID - 10.3389/fnut.2026.1743897 [doi] LID - 1743897 AB - INTRODUCTION: Globally, comprehensive education systems for improved public health are thought to include food and nutrition education. The Sustainable Development Goals 2, 3, 4, and 12 are all clearly advocating this. Food and Nutrition Education (FNE) is still implemented unevenly and primarily depends on individual teachers, even with the strong support of policies like India's NEP 2020 and UNESCO's 2024 Global Education Monitoring Report. The current study investigated whether primary school teachers who felt supported by their schools are sufficiently confident in their teaching methods to convert national and international policies and guidelines into real, useful lessons at the classroom level. METHODS: Our study utilized a convergent mixed-methods approach. We surveyed a total of 427 teachers from 12 government primary schools in Tamil Nadu, India. Schools were selected through purposive maximum variation sampling across urban (Chennai) and five adjacent rural districts, and teachers were identified based on continuous service in Grades 1 to 5. Five domain experts validated the instrument with a CVR = 0.94, which included self-efficacy, training history, curricular preferences, and perceived barriers, all of which used a 5-point Likert scale. To analyze quantitative data, SPSS was used v28.0. Levene's test was used to test the homogeneity of variance, and independent samples t-tests were used to compare means between urban and rural areas. The associations between the main variables were quantified using Pearson's r. Implementation confidence was predicted using a hierarchical multiple regression model, after controlling for location, years of experience, training exposure and school infrastructure. The 32 semi-structured interviews were transcribed, translated, and analyzed thematically following Braun and Clarke's framework and inter-coder reliability was found to be kappa = 0.89. The design is in response to the call of OECD for teacher agency in the localization of curriculum. RESULTS: A striking 79.4% of teachers reported no formal training in nutrition pedagogy. Self-efficacy scores were significantly lower among rural teachers (M = 2.0, SD = 0.7) than among their urban counterparts (M = 3.5, SD = 0.8; t(425) = -8.17, p < 0.001, d = 1.63). Teacher confidence was strongly correlated with advocacy for a standalone FNE subject (r = 0.73, p < 0.001). Regression analysis revealed that prior training (beta = 0.54, p < 0.001) and urban location (beta = 0.33, p = 0.001) were the strongest predictors of implementation confidence, together explaining 67% of the variance (R (2) = 0.67, adjusted R (2) = 0.65, F (4, 422) = 78.93, p < 0.001). Qualitative analysis yielded three robust themes: (1) the syllabus squeeze, a structural barrier to dedicated FNE time; (2) the cultural privileging of doctor-led authority over pedagogical expertise; and (3) the absence of state-mandated, contextually relevant teaching modules. DISCUSSION: This research transcends the anecdotal call for the training of teachers by empirically grounding and identifying policy-actionable deficits in educators' capacity. The data clearly show that FNE will remain a peripheral aspiration rather than a core competency if the best pedagogical practices are not adapted. Based on England's statutory Cooking and Nutrition framework, we suggest instituting required FNE modules in B.Ed. and D.Ed. programs to comply with the WHO's 2023 School Nutrition Policy Guidelines while resolving regional delivery issues. CONCLUSION: Therefore, it is crucial to make systematic and ongoing investments in their professional development if primary educators are to confidently deliver food and nutrition education that supports children's growth and development alongside core literacy and numeracy. The shift from merely endorsing policies to building capacity based on evidence is long overdue. Apart from India, many LMICs share the identified obstacles of training gaps, curriculum marginalization, and cultural deference to non-educators. For any LMIC hoping to operationalize global FNE commitments through empowered, classroom-ready teachers, the study provides a scalable diagnostic and prescriptive framework for measuring training exposure, self-efficacy disparities, curricular legitimacy, and institutional barriers to FNE in LMIC contexts. CI - Copyright (c) 2026 Ilangovan, Xavier and Govindarajan. FAU - Ilangovan, Ajit AU - Ilangovan A AD - Vellore Institute of Technology - Chennai Campus, Chennai, India. FAU - Xavier, Savariah AU - Xavier S AD - Vellore Institute of Technology - Chennai Campus, Chennai, India. FAU - Govindarajan, P AU - Govindarajan P AD - Vellore Institute of Technology - Chennai Campus, Chennai, India. LA - eng PT - Journal Article DEP - 20260701 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13368667 OTO - NOTNLM OT - curriculum integration OT - food literacy OT - nutrition education policy OT - pedagogical capacity OT - primary education reform COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/16 06:39 MHDA- 2026/07/16 06:40 PMCR- 2026/07/01 CRDT- 2026/07/16 04:39 PHST- 2025/11/11 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/16 06:40 [medline] PHST- 2026/07/16 06:39 [pubmed] PHST- 2026/07/16 04:39 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 10.3389/fnut.2026.1743897 [doi] PST - epublish SO - Front Nutr. 2026 Jul 1;13:1743897. doi: 10.3389/fnut.2026.1743897. eCollection 2026. PMID- 42458481 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260822 IS - 1479-5876 (Electronic) IS - 1479-5876 (Linking) VI - 24 IP - 1 DP - 2026 Jul 15 TI - Handgrip strength in children, adolescents, and young adults with suspected myalgic encephalomyelitis/chronic fatigue syndrome. LID - 10.1186/s12967-026-08654-5 [doi] LID - 947 AB - BACKGROUND: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) in children and young people (CYP) lacks validated diagnostic biomarkers. Post-exertional malaise (PEM) is central to case definitions and is usually assessed by patient report. We evaluated the feasibility and clinical value of handgrip strength (HGS) testing in PEM-reporting CYP referred for suspected ME/CFS. METHODS: In this prospective observational study at the Munich Chronic Fatigue Center for Young People (November 2022-November 2024), 147 patients (10-25 years) referred for the assessment of ME/CFS with positive DSQ-PEM screening and 83 healthy controls (HC) completed two HGS sessions (10 maximal grips/session; 3-s contraction/5-s rest; 60-minute inter-session break) using a digital dynamometer. We derived maximal force (Fmax), mean force (Fmean), fatigue ratio (FR = Fmax/Fmean), and recovery ratio (RR = Fmean session 2 / session 1). Analyses used repeated-measures ANCOVA, linear regression, partial Spearman correlations (adjusted for sex, age, and BMI), and proportional odds models for group membership (HC, noME/CFS, ME/CFS), reporting accuracy, and the C-statistic. Sensitivity analyses compared noME/CFS with confirmed CCC-ME/CFS. RESULTS: After clinical work-up, 84/147 (57%) patients were classified as ME/CFS (confirmed or probable) and 63/147 (43%) as noME/CFS. HGS test completion rate was high (session 1: 146/147, 99.3%; session 2: 142/147, 96.6%). Compared with HC, patients had substantially lower HGS (mean difference -9.93 kg, 95% CI: -12.00 to -7.85), and HGS indices correlated modestly with physical functioning (SF-12 PCS), but not with PEM duration. Both noME/CFS and ME/CFS groups differed from HC in absolute strength indices (Fmean, Fmax) and FR. RR differed between ME/CFS and HC, whereas no HGS index significantly separated noME/CFS from ME/CFS. In proportional odds models, each HGS index improved fit (all p < 0.001), but discrimination across HC, noME/CFS, and ME/CFS patients was moderate (accuracy 49.2-57.3% vs no-information rate 36.5%, with best performance for Fmean in session 2). In the CCC-restricted sensitivity analysis, discrimination between confirmed CCC-ME/CFS and noME/CFS was moderate (accuracy 62.8-70.7%; C-statistic 0.63-0.73), with best performance for absolute strength indices and RR. CONCLUSIONS: Standardized two-session repeated HGS testing is feasible in CYP with chronic fatigue and self-reported PEM and provides an objective marker of functional impairment that aligns with physical health status but not with PEM duration. However, HGS alone shows limited ability to discriminate ME/CFS from other fatiguing noME/CFS conditions. HGS may be useful for quantitative phenotyping, patient stratification, and longitudinal outcome assessment rather than as a standalone diagnostic biomarker. TRIAL REGISTRATION: Not applicable. CI - (c) 2026. The Author(s). FAU - Mihatsch, Lorenz AU - Mihatsch L AUID- ORCID: 0000-0003-3835-7964 AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. L.Mihatsch@tum.de. FAU - Schartner, Lisa AU - Schartner L AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - de Luna, Julia Lange AU - de Luna JL AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Hohler, Chiara AU - Hohler C AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Bucka, Lara AU - Bucka L AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Lovrenovic, Lea AU - Lovrenovic L AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Eidenschink, Sophie AU - Eidenschink S AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Schmuck, Birgit AU - Schmuck B AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Bienemann, Viktoria AU - Bienemann V AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Christa, Catharina AU - Christa C AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Mittelstrass, Kirstin AU - Mittelstrass K AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Hausruckinger, Anna AU - Hausruckinger A AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Warlitz, Cordula AU - Warlitz C AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Michel, Kaja AU - Michel K AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Gerrer, Katrin AU - Gerrer K AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Freitag, Helma AU - Freitag H AD - Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Institute of Medical Immunology, Augustenburger Platz 1, Berlin, 13353, Germany. FAU - Scheibenbogen, Carmen AU - Scheibenbogen C AD - Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Institute of Medical Immunology, Augustenburger Platz 1, Berlin, 13353, Germany. FAU - Pricoco, Rafael AU - Pricoco R AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. FAU - Behrends, Uta AU - Behrends U AD - Technical University of Munich; TUM School of Medicine and Health, Children's Hospital, Munich Chronic Fatigue Center for Young People (MCFC), Munich, Germany. AD - German Center for Infection Research, Partnersite Munich, Munich, Germany. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260715 PL - England TA - J Transl Med JT - Journal of translational medicine JID - 101190741 SB - IM MH - Humans MH - *Fatigue Syndrome, Chronic/physiopathology/diagnosis MH - *Hand Strength/physiology MH - Child MH - Adolescent MH - Female MH - Young Adult MH - Male MH - Adult MH - Case-Control Studies PMC - PMC13393269 OTO - NOTNLM OT - Handgrip strength OT - ME/CFS OT - PEM OT - Pediatrics OT - Post-COVID OT - Post-Exertional malaise OT - Post-Vaccination COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Institutional Review Board of the TUM University Hospital (2022-585_1) and adheres to the Declaration of Helsinki and its subsequent amendments. Written informed consent was obtained from all participants prior to their inclusion, and in case of minors, from their legal guardians. Consent for publication: Not applicable. Competing interest: U.B. reports research funding from the Bavarian State Ministry of Health and Care, the Bavarian State Ministry of Science and Art, the German Center for Infection Research (DZIF), the Federal Ministry of Research, Technology and Space, the Federal Ministry of Health, and the Federal Joint Committee. All other authors report no conflict of interest. EDAT- 2026/07/16 00:35 MHDA- 2026/07/23 06:39 PMCR- 2026/07/15 CRDT- 2026/07/16 00:01 PHST- 2026/03/08 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/23 06:39 [medline] PHST- 2026/07/16 00:35 [pubmed] PHST- 2026/07/16 00:01 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.1186/s12967-026-08654-5 [pii] AID - 8654 [pii] AID - 10.1186/s12967-026-08654-5 [doi] PST - epublish SO - J Transl Med. 2026 Jul 15;24(1):947. doi: 10.1186/s12967-026-08654-5. PMID- 42458400 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261016 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jul 15 TI - Panoramic radiograph-based dental age estimation in children and adolescents using multi-tooth methods: a scoping review of methods used and reported accuracy (2020-2025). LID - 10.1186/s12903-026-09263-w [doi] LID - 2005 AB - BACKGROUND: Accurate dental age estimation supports treatment planning in pediatric dentistry and orthodontics and forensic assessment when chronological age is uncertain. Because the accuracy of panoramic radiograph-based methods varies across populations, age groups, and method variants, a contemporary synthesis is needed to guide method selection. OBJECTIVE: To map the methods used for panoramic radiograph-based dental age estimation in children and adolescents and to summarize the reported diagnostic accuracy of the most frequently used method families in studies published between 2020 and 2025. METHODS: This scoping review was conducted using PubMed, Scopus, and Web of Science. Studies published between 1 January 2020 and 31 December 2025 were screened according to predefined eligibility criteria. Data were extracted using a standardized form, including study characteristics, dental age estimation methods, and reported accuracy outcomes (primarily mean absolute error [MAE] and mean difference/bias [DA-CA]). Thirty-four original studies were included. RESULTS: The included studies comprised over 35,000 children and adolescents from multiple countries and were predominantly retrospective and clinic-based. Willems-family methods were the most frequently reported, followed by Demirjian-, Cameriere-, and London Atlas-based approaches. Across studies, accuracy reporting was heterogeneous with respect to MAE, bias metrics, sex stratification, and method variants. Cameriere family methods often showed lower MAE values in many cohorts; however, performance varied by population, age range, and method modification. CONCLUSION: Panoramic radiograph-based dental age estimation methods show substantial heterogeneity in use and reported accuracy across populations. Willems-family methods are the most frequently applied, whereas Cameriere-family methods often demonstrate favorable accuracy in many cohorts, but no single method can be considered universally optimal. Population-specific validation and standardized reporting of accuracy metrics are needed. CI - (c) 2026. The Author(s). FAU - Lysiak-Majchrzak, Malgorzata AU - Lysiak-Majchrzak M AUID- ORCID: 0009-0003-0611-173X AD - Department of Maxillofacial Orthopedics and Orthodontics, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland. malgorzata.lysiak-majchrzak@cm.umk.pl. FAU - Jagla, Sylwia AU - Jagla S AUID- ORCID: 0000-0002-6709-334X AD - Department of Maxillofacial Orthopedics and Orthodontics, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland. FAU - Kazimierczak, Natalia AU - Kazimierczak N AUID- ORCID: 0000-0002-1850-3525 AD - Department of Maxillofacial Orthopedics and Orthodontics, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland. AD - Kazimierczak Clinic, Dworcowa 13/u6a, Bydgoszcz, Poland. FAU - Kazimierczak, Wojciech AU - Kazimierczak W AUID- ORCID: 0000-0002-8372-0550 AD - Kazimierczak Clinic, Dworcowa 13/u6a, Bydgoszcz, Poland. AD - Department of Radiology and Diagnostic Imaging, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland. FAU - Matthews-Brzozowska, Teresa AU - Matthews-Brzozowska T AUID- ORCID: 0000-0002-7127-6018 AD - Department of Maxillofacial Orthopedics and Orthodontics, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland. LA - eng PT - Journal Article PT - Scoping Review PT - Systematic Review DEP - 20260715 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - *Radiography, Panoramic/methods MH - Child MH - Adolescent PMC - PMC13663167 OTO - NOTNLM OT - Accuracy OT - Cameriere Method OT - Child OT - Dental Age OT - Panoramic radiography OT - Tooth OT - Willems Method COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: All authors have approved the manuscript for submission. Competing interests: The authors declare no competing interests. EDAT- 2026/07/16 00:35 MHDA- 2026/10/14 05:33 PMCR- 2026/07/15 CRDT- 2026/07/15 23:58 PHST- 2026/03/04 00:00 [received] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/10/14 05:33 [medline] PHST- 2026/07/16 00:35 [pubmed] PHST- 2026/07/15 23:58 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.1186/s12903-026-09263-w [pii] AID - 9263 [pii] AID - 10.1186/s12903-026-09263-w [doi] PST - epublish SO - BMC Oral Health. 2026 Jul 15;26(1):2005. doi: 10.1186/s12903-026-09263-w. PMID- 42458369 OWN - NLM STAT- MEDLINE DCOM- 20260924 LR - 20260926 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 15 TI - Agreement between household food insecurity access scale and an imputed food consumption score in urban Ethiopia: implications for targeting. LID - 10.1186/s12887-026-07340-1 [doi] LID - 898 AB - BACKGROUND: The Food Consumption Score (FCS) and Household Food Insecurity Access Scale (HFIAS) measure different domains of food security, namely dietary diversity versus perceived access constraints. In urban Ethiopia, it is unknown whether these indicators classify the same households as food insecure. This study compared FCS and HFIAS classifications among households with young children and quantified discordance between the two measures. METHODS: This secondary analysis used cross-sectional data from 542 households with children aged 6-23 months attending public health centers in Harar City, Eastern Ethiopia (July-August 2024). The original study assessed determinants of animal-source food consumption; the current comparative analysis was a pre-specified secondary objective. FCS was calculated from 7-day food frequency data using standard WFP thresholds. Missing oil and sugar values (100% missing) were imputed as 3 days/week with sensitivity analyses under alternative assumptions. HFIAS categories used continuous score cutoffs validated in Ethiopian studies. Agreement was assessed using Cohen's kappa, prevalence-adjusted bias-adjusted kappa (PABAK), and discordance analysis. Bootstrap methods calculated 95% confidence intervals. Multivariable logistic regression identified predictors of discordance. RESULTS: FCS classified 34.5% as acceptable, 28.6% borderline, and 36.9% poor. HFIAS classified 20.1% as food secure, 28.0% mildly, 33.0% moderately, and 18.8% severely insecure. Overall agreement was 48.5% with kappa of 0.31 (95% CI: 0.25-0.37), indicating fair agreement. PABAK was 0.42 (95% CI: 0.36-0.48). Discordance occurred in 51.5% of households: 22.9% were HFIAS-secure but FCS poor/borderline; 28.6% were HFIAS-insecure but FCS acceptable. Poorest wealth quintile (AOR = 2.43, 95% CI: 1.38-4.28) and no maternal education (AOR = 1.87, 95% CI: 1.12-3.14) were independently associated with higher odds of discordance. CONCLUSIONS: FCS and HFIAS measure different dimensions of household food security and demonstrate only fair agreement in this urban Ethiopian population. Neither measure alone provides a complete picture. The finding that more than half of households are discordantly classified highlights the importance of measuring both dietary consumption and perceived access whenever resources permit. The choice of indicator should be guided by assessment objectives and available resources. CI - (c) 2026. The Author(s). FAU - Belay, Bira AU - Belay B AUID- ORCID: 0009-0006-3969-1744 AD - School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia. birabelay555@gmail.com. FAU - Nega, Bereketabe AU - Nega B AD - School of Public Health, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia. FAU - Daba, Yalo AU - Daba Y AD - Pharmacology Department, College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia. LA - eng PT - Journal Article DEP - 20260715 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Ethiopia MH - Humans MH - *Food Insecurity MH - Cross-Sectional Studies MH - Male MH - Female MH - Urban Population MH - Infant MH - *Food Supply/statistics & numerical data MH - *Family Characteristics PMC - PMC13602524 OTO - NOTNLM OT - Agreement OT - Cohen's kappa OT - Dietary diversity OT - Ethiopia OT - FCS OT - Food Consumption Score OT - Food insecurity OT - HFIAS OT - Urban COIS- Declarations. Ethics approval and consent to participate: The original study received ethical approval from Haramaya University's Institutional Health Research Ethics Review Committee (Ref: IHRERC/164/2024). Written informed consent was obtained from all participating mothers. This secondary analysis of de-identified data was reviewed by the same committee and granted exemption from full review (Ref: IHRERC/045/2024) on the basis that it involved analysis of existing, anonymized data with no participant contact. All procedures complied with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/16 00:34 MHDA- 2026/09/24 05:36 PMCR- 2026/07/15 CRDT- 2026/07/15 23:57 PHST- 2026/05/13 00:00 [received] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/09/24 05:36 [medline] PHST- 2026/07/16 00:34 [pubmed] PHST- 2026/07/15 23:57 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.1186/s12887-026-07340-1 [pii] AID - 7340 [pii] AID - 10.1186/s12887-026-07340-1 [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 15;26(1):898. doi: 10.1186/s12887-026-07340-1. PMID- 42456231 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260826 IS - 1878-7487 (Electronic) IS - 1752-928X (Linking) VI - 122 DP - 2026 Aug TI - Classifying legal age of majority (>/=18 years) from panoramic radiographs with transfer learning: Benchmarking ViT and EfficientNetV2. PG - 103215 LID - S1752-928X(26)00148-4 [pii] LID - 10.1016/j.jflm.2026.103215 [doi] AB - OBJECTIVE: To assess whether transfer-learning models applied to panoramic radiographs (PANs) can classify individuals at the threshold of legal majority (>/=18 years). MATERIALS AND METHODS: Vision Transformer (ViT) and EfficientNetV2 models were trained on PANs from Bosnian and Lebanese individuals aged 14-24.99 years (n = 1764), considering pooled and sex-specific datasets with and without augmentation. Binary classification, multiclass classification, and regression models were trained and evaluated. Model performance on an internal test set derived from the same sample was summarized using accuracy, sensitivity, specificity, F1 score, and area under the receiver operating characteristic curve (ROC AUC). For regression and multiclass models, legal majority classification was additionally assessed by thresholding predicted ages or age categories at 18 years. External validation employed an independent Brazilian dataset (n = 1579; 14-24.99 years). Formal statistical comparison between internal and external performance employed two-proportion z-tests for accuracy and DeLong's test for ROC AUC. RESULTS: On the internal test set, the best-performing binary classification model, EfficientNetV2 with augmentation on the pooled dataset, achieved an accuracy of 0.90, sensitivity of 0.92, specificity of 0.86, F1 score of 0.91, and ROC AUC of 0.93. Using the same pooled, augmented configuration, thresholded regression predictions achieved accuracies of 0.85 for EfficientNetV2 and 0.83 for ViT, whereas thresholded multiclass predictions achieved accuracies of 0.84 and 0.73, respectively. Compared with direct binary classification, these thresholded outputs showed no clear advantage, and multiclass models generally showed higher specificity but lower sensitivity. This same pattern was retained when thresholded models were evaluated on the external validation set, with thresholded regression remaining comparatively stable and thresholded multiclass performance declining more markedly, especially for ViT. Visualization maps (gradient-weighted class activation mapping [Grad-CAM] and occlusion sensitivity) confirmed attention to relevant dental structures. On external validation, the same binary EfficientNetV2 configuration achieved an accuracy of 0.81, sensitivity of 0.90, specificity of 0.61, F1 score of 0.87, and ROC AUC of 0.85. Sex-specific models performed similarly, showing no clear advantage over pooled training. Statistical testing confirmed significant AUC degradation on external validation for both models (EfficientNetV2: p = 0.004; ViT: p < 0.001), while the accuracy drop was significant only for ViT (p = 0.035). CONCLUSIONS: This study demonstrated that transfer learning with EfficientNetV2 and Vision Transformer can distinguish minors from adults using PANs with high internal performance and acceptable external generalization. Direct binary classification provided the most robust approach for legal age assessment in the present dataset. The findings support the forensic potential of these models, while also indicating the need for further work to improve robustness and real-world applicability. CI - Copyright (c) 2026 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved. FAU - Constantinou, Chrysovalantis AU - Constantinou C AD - Computation-based Science and Technology Research Center, The Cyprus Institute, Aglantzia, Nicosia, 2121, Cyprus. Electronic address: cconsta1@alumni.nd.edu. FAU - Georgiades, Pantelis AU - Georgiades P AD - Computation-based Science and Technology Research Center, The Cyprus Institute, Aglantzia, Nicosia, 2121, Cyprus; Climate and Atmosphere Research Centre, The Cyprus Institute, Aglantzia, Nicosia, 2121, Cyprus. FAU - Angelakopoulos, Nikolaos AU - Angelakopoulos N AD - Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Bern, Switzerland; Department of Forensic Dentistry, Faculdade Sao Leopoldo Mandic, Campinas, Brazil. FAU - Hadzic Selmanagic, Aida AU - Hadzic Selmanagic A AD - Department of Dental Morphology with Dental Anthropology and Forensics, Faculty of Dentistry, University of Sarajevo, Sarajevo, Bosnia and Herzegovina. FAU - Dervisevic, Emina AU - Dervisevic E AD - Department of Forensic Medicine, Faculty of Medicine, University of Sarajevo, Sarajevo, Bosnia and Herzegovina. FAU - Moukarzel, Maria AU - Moukarzel M AD - Private Dental Practice, Beirut, Lebanon. FAU - Franco, Ademir AU - Franco A AD - Department of Forensic Dentistry, Faculdade Sao Leopoldo Mandic, Campinas, Brazil. FAU - Merdietio Boedi, Rizky AU - Merdietio Boedi R AD - Department of Dentistry, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia. LA - eng PT - Journal Article DEP - 20260715 PL - England TA - J Forensic Leg Med JT - Journal of forensic and legal medicine JID - 101300022 SB - IM MH - Humans MH - *Radiography, Panoramic MH - Adolescent MH - *Age Determination by Teeth/methods MH - Young Adult MH - Female MH - Male MH - ROC Curve MH - Classification Algorithms MH - Sensitivity and Specificity OTO - NOTNLM OT - Dental age classification OT - Forensic dentistry OT - Legal age of majority OT - Panoramic radiograph OT - Transfer learning COIS- Conflict of interest The authors declare no competing interests. EDAT- 2026/07/15 18:41 MHDA- 2026/08/26 23:35 CRDT- 2026/07/15 18:01 PHST- 2025/03/11 00:00 [received] PHST- 2026/05/17 00:00 [revised] PHST- 2026/07/14 00:00 [accepted] PHST- 2026/08/26 23:35 [medline] PHST- 2026/07/15 18:41 [pubmed] PHST- 2026/07/15 18:01 [entrez] AID - S1752-928X(26)00148-4 [pii] AID - 10.1016/j.jflm.2026.103215 [doi] PST - ppublish SO - J Forensic Leg Med. 2026 Aug;122:103215. doi: 10.1016/j.jflm.2026.103215. Epub 2026 Jul 15. PMID- 42455961 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1520-7560 (Electronic) IS - 1520-7552 (Print) IS - 1520-7552 (Linking) VI - 42 IP - 5 DP - 2026 Jul TI - Disordered Eating Behaviours and Associated Factors Among People With Type 1 Diabetes: A Cross-Sectional Study in Spain-D1ANAS Project. PG - e70204 LID - 10.1002/dmrr.70204 [doi] LID - e70204 AB - BACKGROUND AND AIMS: People with type 1 diabetes mellitus (T1D) are at increased risk of disordered eating behaviours (DEBs), partly due to aspects of diabetes management. The aim of this study was to estimate the prevalence of DEBs in a group of adults with T1D in Spain and to examine their association with sociodemographic, clinical, and lifestyle-related factors. METHODS: A nationwide cross-sectional study was conducted as part of the D1ANAS project, involving 451 people aged >/= 16 years with T1D living in Spain. DEBs were assessed using the validated Spanish version of the Diabetes Eating Problems Survey-Revised (DEPS-R), with scores >/= 20 indicating a positive screening. Sociodemographic, clinical, and lifestyle variables were collected using a self-administered online questionnaire. Multivariate linear regression analyses were performed to identify factors independently associated with the total DEPS-R score. RESULTS: The mean DEPS-R score was 16.8 (SD 12.1), and 31.7% of participants screened positive for DEBs, with higher prevalence in women than men (35.4% vs. 14.8%, p < 0.001) 36.6% of participants reported insulin restriction behaviours, with no significant differences between sexes. In the adjusted models, female sex (beta = 3.23, 95% CI = 0.65-5.82), higher HbA1c percentage (beta = 2.12, 95% CI = 1.32-2.93), and higher zBMI (beta = 3.44, 95% CI = 2.44-4.44) were independently associated with higher DEPS-R scores, as were poorer perceived health (beta = 5.11, 95% CI = 2.25-7.96), poorer diet quality (beta = 13.42, 95% CI = 7.23-19.61) and poor sleep perception (beta = 3.43, 95% CI = 1.46-5.39). The model explained 29.6% of the variance in DEPS-R scores. CONCLUSION: DEBs affect about one-third of the participants with T1D and are associated with poorer metabolic control, higher BMI, and adverse lifestyle and psychosocial factors, highlighting the need for diabetes-specific screening and multidisciplinary management. CI - (c) 2026 The Author(s). Diabetes/Metabolism Research and Reviews published by John Wiley & Sons Ltd. FAU - Botella-Juan, Lorena AU - Botella-Juan L AUID- ORCID: 0000-0002-4886-1673 AD - Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Faculty of Health Sciences, Universidad de Leon, Leon, Spain. AD - Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiologia y Salud Publica [CIBERESP]), Madrid, Spain. AD - The Research Group in Gene‑Environment and Health Interactions (GIIGAS), Institute Biomedicine (IBIOMED), Universidad de Leon, Leon, Spain. FAU - Aguilera-Buenosvinos, Inmaculada AU - Aguilera-Buenosvinos I AUID- ORCID: 0000-0002-9484-7303 AD - Faculty of Health Sciences, International University of La Rioja, Logrono, Spain. FAU - Antequera-Gonzalez, Maria AU - Antequera-Gonzalez M AD - Servicio de Endocrinologia y Nutricion, Complejo Asistencial Universitario de Leon, Gerencia de Salud de Castilla y Leon (SACYL), Leon, Spain. FAU - Alvarez-Alvarez, Laura AU - Alvarez-Alvarez L AUID- ORCID: 0000-0002-4915-8314 AD - Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Faculty of Health Sciences, Universidad de Leon, Leon, Spain. AD - Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiologia y Salud Publica [CIBERESP]), Madrid, Spain. AD - The Research Group in Gene‑Environment and Health Interactions (GIIGAS), Institute Biomedicine (IBIOMED), Universidad de Leon, Leon, Spain. FAU - Rubin-Garcia, Maria AU - Rubin-Garcia M AUID- ORCID: 0000-0003-0916-4215 AD - Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Faculty of Health Sciences, Universidad de Leon, Leon, Spain. AD - Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiologia y Salud Publica [CIBERESP]), Madrid, Spain. AD - The Research Group in Gene‑Environment and Health Interactions (GIIGAS), Institute Biomedicine (IBIOMED), Universidad de Leon, Leon, Spain. FAU - Romeo-Santos, Maria AU - Romeo-Santos M AD - Hospital General Universitario Gregorio Maranon, Madrid, Spain. FAU - Segura-Grau, Ana AU - Segura-Grau A AUID- ORCID: 0000-0003-3701-2788 AD - Ultrasound Unit, Family and Community Medicine, San Francisco de Asis Hospital, Madrid, Spain. AD - SEMERGEN (Spanish Society of Primary Care Physicians), Madrid, Spain. FAU - Ballesteros-Pomar, Maria D AU - Ballesteros-Pomar MD AUID- ORCID: 0000-0002-5729-9926 AD - Servicio de Endocrinologia y Nutricion, Complejo Asistencial Universitario de Leon, Gerencia de Salud de Castilla y Leon (SACYL), Leon, Spain. AD - Instituto de Investigacion Biosanitaria de Leon (IBIOLEON), Leon, Spain. FAU - Molina, Antonio Jose AU - Molina AJ AUID- ORCID: 0000-0002-5948-6397 AD - Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Faculty of Health Sciences, Universidad de Leon, Leon, Spain. AD - Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiologia y Salud Publica [CIBERESP]), Madrid, Spain. AD - The Research Group in Gene‑Environment and Health Interactions (GIIGAS), Institute Biomedicine (IBIOMED), Universidad de Leon, Leon, Spain. FAU - Martin-Sanchez, Vicente AU - Martin-Sanchez V AUID- ORCID: 0000-0003-0552-2804 AD - Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Faculty of Health Sciences, Universidad de Leon, Leon, Spain. AD - Consortium for Biomedical Research in Epidemiology & Public Health (CIBER Epidemiologia y Salud Publica [CIBERESP]), Madrid, Spain. AD - The Research Group in Gene‑Environment and Health Interactions (GIIGAS), Institute Biomedicine (IBIOMED), Universidad de Leon, Leon, Spain. LA - eng PT - Journal Article PL - England TA - Diabetes Metab Res Rev JT - Diabetes/metabolism research and reviews JID - 100883450 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/complications/psychology MH - Female MH - Cross-Sectional Studies MH - Male MH - *Feeding and Eating Disorders/epidemiology/etiology/psychology MH - Spain/epidemiology MH - Adult MH - Prevalence MH - Middle Aged MH - Young Adult MH - Adolescent MH - Risk Factors MH - Follow-Up Studies MH - *Feeding Behavior/psychology MH - Life Style MH - Prognosis MH - Surveys and Questionnaires PMC - PMC13372235 OTO - NOTNLM OT - diabetes mellitus OT - disordered eating behaviours OT - eating disorders OT - type 1 diabetes COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 18:41 MHDA- 2026/07/15 18:42 PMCR- 2026/07/15 CRDT- 2026/07/15 14:13 PHST- 2026/06/12 00:00 [revised] PHST- 2026/03/20 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/07/15 18:42 [medline] PHST- 2026/07/15 18:41 [pubmed] PHST- 2026/07/15 14:13 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - DMRR70204 [pii] AID - 10.1002/dmrr.70204 [doi] PST - ppublish SO - Diabetes Metab Res Rev. 2026 Jul;42(5):e70204. doi: 10.1002/dmrr.70204. PMID- 42455871 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260715 LR - 20260813 IS - 2767-3170 (Electronic) IS - 2767-3170 (Linking) VI - 5 IP - 7 DP - 2026 Jul TI - Development, internal and external evaluation of an artificial intelligence algorithm for child growth monitoring in primary care. PG - e0001526 LID - 10.1371/journal.pdig.0001526 [doi] LID - e0001526 AB - Our goal was to improve growth monitoring in children by developing and evaluating an artificial intelligence (AI) algorithm that can detect abnormal growth. We used pre-diagnosis height measurements for children with a diagnosis of growth hormone deficiency (GHD, n = 86) or Turner syndrome (TS, n = 87) in France (1990-2014) and all height measurements of apparently healthy children (referents, n = 923). We modeled the individual height growth curves by applying non-linear mixed models for each new measurement of each child. The resulting growth parameters were used in multinomial logistic regression across five pre-defined age ranges from 1 to 12 years to predict abnormal growth trajectories. For the five age-specific predictive models, we studied the discrimination and calibration curves, and retained the risk thresholds that offered a pre-defined specificity of 98%. Using all the available height measurements for cases and referents, we evaluated the cumulative diagnostic performance of the algorithm for detecting GHD or TS and the theoretical reduction in time to diagnosis. We evaluated these models internally using 5-fold cross-validation and externally from a regional sample of children with GHD (n = 77) or TS (n = 40) and a national sample of apparently healthy children (n = 5,755). The five age-specific predictive models had good discrimination (high AUROC range 0.87-0.99) and good calibration. Internal evaluations showed stable results. External evaluation revealed a cumulative sensitivity and specificity of 84.6% (95% CI 76.8-90.6) and 94.3% (93.6-94.9). The median theoretical reduction in time to diagnosis was 2.0 years (interquartile range 0.6-3.8): 1.6 years (0.5-2.8) for GHD and 3.0 years (1.0-5.4) for TS. To conclude, we developed and internally and externally evaluated an AI algorithm with high diagnostic performance for the early detection of GHD and TS. A refinement of the algorithm to include other target conditions and further external evaluation in other countries is needed before implementation in daily practice. CI - Copyright: (c) 2026 Scherdel et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Scherdel, Pauline AU - Scherdel P AUID- ORCID: 0000-0003-4517-9430 AD - Universite Paris Cite and Universite Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France. FAU - Houlbracq, Raphaele AU - Houlbracq R AD - Universite Paris Cite and Universite Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France. FAU - Lecoeur, Emmanuel AU - Lecoeur E AD - Universite Paris Cite, Inserm, UMR1343, Pharmacologie et Evaluations des Therapeutiques Chez l'enfant et la Femme Enceinte, Paris, France. AD - Unite de Recherche Clinique, Universite Paris Cite Necker/Cochin, Paris, France. FAU - Leger, Juliane AU - Leger J AD - Department of Pediatric Endocrinology and Diabetology, Robert-Debre Hospital, AP-HP, Universite Paris Cite, Paris, France. AD - Reference Centre for Endocrine Growth and Development Diseases, Paris, France. FAU - Brauner, Raja AU - Brauner R AD - Unite d'Endocrinologie Pediatrique, Hopital Fondation Adolphe de Rothschild, Paris, France. FAU - Cohen, Jeremie F AU - Cohen JF AD - Universite Paris Cite and Universite Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France. AD - Department of General Pediatrics and Pediatric Infectious Diseases, Necker-Enfants Malades Hospital, AP-HP, Universite Paris Cite, Paris, France. CN - EBGM V Study Group FAU - Chalumeau, Martin AU - Chalumeau M AD - Universite Paris Cite and Universite Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France. AD - Department of General Pediatrics and Pediatric Infectious Diseases, Necker-Enfants Malades Hospital, AP-HP, Universite Paris Cite, Paris, France. FAU - Heude, Barbara AU - Heude B AD - Universite Paris Cite and Universite Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Paris, France. LA - eng PT - Journal Article DEP - 20260715 PL - United States TA - PLOS Digit Health JT - PLOS digital health JID - 9918335064206676 PMC - PMC13372244 COIS- I have read the journal's policy and the authors of this manuscript have the following competing interests: BH, MC, and PS are the co-inventors and co-owners of a European patent application (26 305 183.1, filed on February 11, 2026) for the "method and system for monitoring child growth and detecting growth disorders". No other relationships or activities that could appear to have influenced the submitted work are declared. EDAT- 2026/07/15 18:42 MHDA- 2026/07/15 18:43 PMCR- 2026/07/15 CRDT- 2026/07/15 13:53 PHST- 2025/08/27 00:00 [received] PHST- 2026/06/13 00:00 [accepted] PHST- 2026/07/15 18:43 [medline] PHST- 2026/07/15 18:42 [pubmed] PHST- 2026/07/15 13:53 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - PDIG-D-25-00625 [pii] AID - 10.1371/journal.pdig.0001526 [doi] PST - epublish SO - PLOS Digit Health. 2026 Jul 15;5(7):e0001526. doi: 10.1371/journal.pdig.0001526. eCollection 2026 Jul. PMID- 42455830 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Cross-cultural assessment of knowledge and attitudes toward Folic acid: Instrument development and validation in Thailand and Yemen. PG - e0352966 LID - 10.1371/journal.pone.0352966 [doi] LID - e0352966 AB - Folic acid is essential for the prevention of neural tube defects and other congenital anomalies, yet awareness and uptake vary across cultural and resource settings. Reliable tools to assess women's knowledge and attitudes toward Folic acid are limited, particularly in cross-cultural contexts. This study aimed to develop and validate a culturally adaptable questionnaire in two distinct populations: Thailand and Yemen. In this cross-sectional instrument development and validation study, the questionnaire was developed through literature review and expert consultation, and comprised demographics, eight knowledge items, and ten attitude items. Following content validation, pilot testing, and test-retest reliability assessment, exploratory and confirmatory factor analyses were performed. Cronbach's alpha was calculated for internal consistency. Data were collected from 538 women of reproductive age (Thai: 104; Yemeni: 434) via an online self-administered survey. The attitude scale demonstrated strong psychometric properties, with high internal consistency (alpha = 0.88 in both groups), coherent factor structures, and excellent model fit in the Yemeni sample (RMSEA = 0.054, CFI = 0.973, TLI = 0.965). Knowledge scores varied across items, with higher awareness in dietary source and timing-related items, and lower scores in statistical and biological knowledge. The Yemeni version showed lower internal consistency in the knowledge section (alpha = 0.59), reflecting content heterogeneity. Despite contextual differences, the instrument demonstrated psychometric coherence in both groups, though model fit was more robust in the Yemeni sample. In conclusion, this study developed and validated a brief questionnaire to assess knowledge and attitudes toward Folic acid in culturally diverse settings. The tool showed good psychometric performance and is suitable for use in research and public health interventions, particularly in low-resource or cross-cultural environments. CI - Copyright: (c) 2026 Al-Qaari et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Al-Qaari, Rana Ali AU - Al-Qaari RA AD - Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Khuankaew, Saranthorn AU - Khuankaew S AD - Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Suttiserm, Mahittha AU - Suttiserm M AD - Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Pornsuksawang, Siraphat AU - Pornsuksawang S AD - Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Boonnop, Pawat AU - Boonnop P AD - Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Manopatanakul, Somchai AU - Manopatanakul S AUID- ORCID: 0000-0002-6771-2243 AD - Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Khovidhunkit, Siribang-On Piboonniyom AU - Khovidhunkit SP AUID- ORCID: 0000-0002-4496-7964 AD - Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Thiradilok, Sasipa AU - Thiradilok S AD - Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. FAU - Tantipoj, Chanita AU - Tantipoj C AUID- ORCID: 0000-0001-9400-6726 AD - Department of Advanced General Dentistry, Faculty of Dentistry, Mahidol University, Bangkok, Thailand. LA - eng PT - Journal Article PT - Validation Study DEP - 20260715 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 935E97BOY8 (Folic Acid) SB - IM MH - Humans MH - Female MH - *Folic Acid/therapeutic use MH - Yemen MH - *Health Knowledge, Attitudes, Practice MH - Thailand MH - Surveys and Questionnaires MH - Adult MH - Cross-Sectional Studies MH - Psychometrics MH - Cross-Cultural Comparison MH - Reproducibility of Results MH - Young Adult MH - Adolescent PMC - PMC13372155 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/15 18:41 MHDA- 2026/07/15 18:42 PMCR- 2026/07/15 CRDT- 2026/07/15 13:43 PHST- 2025/11/28 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/07/15 18:42 [medline] PHST- 2026/07/15 18:41 [pubmed] PHST- 2026/07/15 13:43 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - PONE-D-25-58912 [pii] AID - 10.1371/journal.pone.0352966 [doi] PST - epublish SO - PLoS One. 2026 Jul 15;21(7):e0352966. doi: 10.1371/journal.pone.0352966. eCollection 2026. PMID- 42455824 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Reliability and validity of the individual GPS game data-based maximal acceleration-initial running speed regression line in youth elite soccer players. PG - e0353385 LID - 10.1371/journal.pone.0353385 [doi] LID - e0353385 AB - Modern load monitoring in soccer increasingly employs relative individualized acceleration intensity thresholds derived from individual maximal acceleration-initial running speed (amax-vinit) regression lines. This study examined the reliability and validity of soccer players' individual amax-vinit regression lines determined solely from game locomotion data. Using a GPS-based tracking system, we prospectively collected game locomotion data from 159 male youth elite soccer players over one season and repeatedly determined their amax-vinit regression lines using a recently introduced game data-based method. To examine the influence of data volume, regression lines were determined using different numbers of consecutive games. As a criterion measure, the amax-vinit regression line was determined using an acceleration test in 55 athletes. Reliability was assessed via the typical error (TE) and the intraclass correlation coefficient (ICC), and validity via the typical error of the estimate (TEE) and the Pearson correlation coefficient. The magnitude of errors and correlation coefficients was assessed using standardization and published thresholds, respectively. Reliability improved gradually with increasing data volume, resulting in TEs of 3.4% (amax intercept), 7.3% (vinit intercept), and 10.3% (slope). Nonetheless, all TEs were large in magnitude, and ICCs very low to low. Validity was unaffected by data volume, with TEEs consistently ~7% (amax intercept), ~ 12% (vinit intercept), and ~17% (slope). All TEEs were assessed as extremely large, and Pearson correlations as impractical. These findings indicate that the game data-based method currently lacks the precision required for individual-level applications, and this limitation cannot be resolved simply by including more games. Therefore, establishing relative individualized acceleration intensity thresholds within a team still requires a test-based approach. Moreover, the results suggest that properties inherent in GPS-based game locomotion data, rather than data volume, underlie the observed imprecision. We propose that substantial future improvements will depend on more precise tracking systems. CI - Copyright: (c) 2026 Andrey et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Andrey, Pascal AU - Andrey P AUID- ORCID: 0000-0002-0812-8899 AD - Department of Elite Sport, Swiss Federal Institute of Sport Magglingen SFISM, Magglingen, Bern, Switzerland. FAU - Fischer-Sonderegger, Karin AU - Fischer-Sonderegger K AD - Department of Elite Sport, Swiss Federal Institute of Sport Magglingen SFISM, Magglingen, Bern, Switzerland. FAU - Taube, Wolfgang AU - Taube W AD - Department of Neurosciences and Movement Science, University of Fribourg, Fribourg, Fribourg, Switzerland. FAU - Tschopp, Markus AU - Tschopp M AUID- ORCID: 0009-0007-3446-2907 AD - Department of Elite Sport, Swiss Federal Institute of Sport Magglingen SFISM, Magglingen, Bern, Switzerland. LA - eng PT - Journal Article DEP - 20260715 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Soccer/physiology MH - *Running/physiology MH - *Geographic Information Systems MH - Male MH - Reproducibility of Results MH - *Acceleration MH - Adolescent MH - *Athletes MH - *Athletic Performance/physiology MH - Regression Analysis PMC - PMC13372162 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/15 18:39 MHDA- 2026/07/15 18:40 PMCR- 2026/07/15 CRDT- 2026/07/15 13:43 PHST- 2025/11/19 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/07/15 18:40 [medline] PHST- 2026/07/15 18:39 [pubmed] PHST- 2026/07/15 13:43 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - PONE-D-25-62317 [pii] AID - 10.1371/journal.pone.0353385 [doi] PST - epublish SO - PLoS One. 2026 Jul 15;21(7):e0353385. doi: 10.1371/journal.pone.0353385. eCollection 2026. PMID- 42455466 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261008 IS - 0973-7693 (Electronic) IS - 0019-5456 (Linking) VI - 93 IP - 10 DP - 2026 Oct TI - Feasibility of Enteral Nutrition in Pediatric Septic Shock at a Tertiary Center in Vietnam. PG - 1052-1057 LID - 10.1007/s12098-026-06324-4 [doi] AB - OBJECTIVES: To evaluate the feasibility and clinical characteristics of early enteral nutrition (EN), defined as initiation within 48 h of PICU admission, in children with septic shock, and to describe clinical characteristics and outcomes according to timing of EN in a resource-limited setting. METHODS: A retrospective observational study was conducted at a national tertiary pediatric intensive care unit in Vietnam. Children aged 1 mo to 16 y diagnosed with septic shock were categorized into early EN (48). Baseline characteristics, illness severity, and clinical outcomes were compared between groups. Multivariable analysis and propensity score matching were performed as exploratory approaches to adjust for confounding. RESULTS: Among 52 patients, 22 (42.3%) received early EN. Patients in the early EN group had lower baseline illness severity. Early EN was successfully implemented in a substantial proportion of patients without observed severe gastrointestinal complications. Lower mortality and more favorable outcomes, including fewer days of mechanical ventilation and reduced need for renal replacement therapy, were observed in the early EN group. However, these findings should be interpreted cautiously given the retrospective design, small sample size, and potential confounding by indication. CONCLUSIONS: Early enteral nutrition was feasible and appeared safe in children with septic shock, even in a resource-limited PICU setting. While favorable outcomes were observed, the study does not establish causality, and further prospective studies are needed to confirm these findings. CI - (c) 2026. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation. FAU - Dau, Hung Viet AU - Dau HV AD - Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, Vietnam. FAU - Hoang, Khuyen Thi Ngoc AU - Hoang KTN AD - Center of Pediatrics, Vinmec Times City International Hospital, Hanoi, Vietnam. FAU - Ngo, Kha Manh AU - Ngo KM AD - Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, Vietnam. FAU - Tran, Hanh My Thi AU - Tran HMT AD - Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, Vietnam. FAU - Hoang, Canh Ngoc AU - Hoang CN AUID- ORCID: 0000-0003-2674-3024 AD - Pediatric Intensive Care Unit, Vietnam National Children's Hospital, Hanoi, Vietnam. ngocanh.nhp@gmail.com. LA - eng PT - Journal Article PT - Observational Study DEP - 20260715 PL - India TA - Indian J Pediatr JT - Indian journal of pediatrics JID - 0417442 SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - *Enteral Nutrition/methods MH - Feasibility Studies MH - Intensive Care Units, Pediatric MH - Resource-Limited Settings MH - Retrospective Studies MH - Severity of Illness Index MH - *Shock, Septic/diagnosis/mortality/therapy MH - Tertiary Care Centers MH - Treatment Outcome MH - Vietnam/epidemiology OTO - NOTNLM OT - Enteral nutrition OT - Feasibility OT - Pediatric intensive care unit OT - Resource-limited settings OT - Septic shock COIS- Declarations. Conflict of Interest: None. EDAT- 2026/07/15 12:35 MHDA- 2026/10/01 05:30 CRDT- 2026/07/15 11:18 PHST- 2026/02/03 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/10/01 05:30 [medline] PHST- 2026/07/15 12:35 [pubmed] PHST- 2026/07/15 11:18 [entrez] AID - 10.1007/s12098-026-06324-4 [pii] AID - 10.1007/s12098-026-06324-4 [doi] PST - ppublish SO - Indian J Pediatr. 2026 Oct;93(10):1052-1057. doi: 10.1007/s12098-026-06324-4. Epub 2026 Jul 15. PMID- 42455187 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260922 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 8 DP - 2026 Jul 15 TI - Ultrasound evaluation of quadriceps muscle thickness and body fat distribution in children receiving maintenance hemodialysis: a cross-sectional case-control study. LID - 10.1007/s00431-026-07212-x [doi] LID - 577 AB - Children on hemodialysis (HD) are at multifactorial nutritional risk. Nutritional assessment in these children is challenging because conventional anthropometric and dietary indicators are influenced by growth failure, chronic inflammation, and fluid shifts. Ultrasound (US)-based muscle assessment has emerged as a practical bedside method for evaluating muscle mass, while data on US-derived fat distribution in this population are limited. This cross-sectional case-control study was conducted at a tertiary HD center and enrolled 42 children on HD and 42 age- and sex-matched apparently healthy children. Demographic, anthropometric, clinical, and laboratory data were collected. Dietary evaluation using a 3-day food intake record was performed. Quadriceps muscle thickness, primarily that of the rectus femoris (RF), was assessed using B-mode muscle US in both groups. Subcutaneous thigh fat, anterior abdominal fat, and visceral fat thickness (VFT) were also assessed to characterize body composition. Total daily calorie intake and protein intake were significantly lower in children on HD (p < 0.001). Children on maintenance HD had significantly lower peripheral muscle thickness than healthy controls. Subcutaneous fat thickness at the thigh and abdominal wall was significantly reduced, whereas VFT was significantly increased in the HD group (p < 0.05). Correlation analysis showed that total caloric and protein intake were positively associated with muscle thickness (p < 0.001). Receiver operating characteristic (ROC) curve analysis showed that RF thickness demonstrated moderate discriminatory ability for nutritional risk, with an area under the curve (AUC) of 0.731 (p < 0.001), whereas US-derived fat measurements showed limited diagnostic performance. CONCLUSION: Quadriceps muscle US appears to be a practical adjunct and complementary assessment tool to conventional nutritional assessment in children receiving maintenance HD. US-derived subcutaneous and visceral fat measurements provide complementary information on body composition and fat distribution. WHAT IS KNOWN: * Children receiving maintenance hemodialysis are at high risk of nutritional impairment, growth failure, and altered body composition, making nutritional assessment challenging. * Ultrasound assessment of quadriceps muscle thickness is a practical bedside method for evaluating muscle mass in adults receiving hemodialysis, but pediatric evidence remains limited. WHAT IS NEW: * This study highlights the utility of bedside US measurement of quadriceps muscle thickness as a practical adjunct for detecting nutritional risk in children on maintenance HD. * This study provides novel pediatric data on US-derived subcutaneous and VFT in children on maintenance HD, revealing an altered fat distribution pattern characterized by reduced peripheral fat and increased visceral fat. CI - (c) 2026. The Author(s). FAU - Gohary, Amal E AU - Gohary AE AD - Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig City, Sharkia Governorate, Egypt. amaleam@zu.edu.eg. FAU - Soliman, Azza Soliman AU - Soliman AS AD - Department of Public Health and Community Medicine, Faculty of Medicine, Zagazig University, Zagazig City, Sharkia Governorate, Egypt. FAU - Eldemerdash, Sara Kamel AU - Eldemerdash SK AD - Department of Diagnostic Radiology, Faculty of Medicine, Zagazig University, Zagazig City, Sharkia Governorate, Egypt. FAU - Elsharkawy, Mona Mohammed AU - Elsharkawy MM AD - Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig City, Sharkia Governorate, Egypt. FAU - Gohary, Mahmoud M AU - Gohary MM AD - Department of Pediatrics, Faculty of Medicine, Zagazig University, Zagazig City, Sharkia Governorate, Egypt. LA - eng PT - Journal Article DEP - 20260715 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Male MH - Case-Control Studies MH - Ultrasonography MH - *Quadriceps Muscle/diagnostic imaging MH - Child MH - *Renal Dialysis/adverse effects MH - *Body Fat Distribution MH - Nutrition Assessment MH - Adolescent MH - ROC Curve MH - *Kidney Failure, Chronic/therapy MH - Child, Preschool PMC - PMC13373012 OTO - NOTNLM OT - Fat distribution OT - Hemodialysis OT - Muscle ultrasound OT - Nutritional risk OT - Quadriceps muscle COIS- Declarations. Ethics approval: Following Institutional Review Board approval (ZU-IRB#751/20), this study was approved by the Pediatrics Department at Zagazig University Hospitals. Legal guardians provided informed consent. The study was conducted in accordance with the Declaration of Helsinki, which outlines ethical principles for research involving human participants. Competing interests: The authors declare no competing interests. EDAT- 2026/07/15 12:35 MHDA- 2026/07/15 12:36 PMCR- 2026/07/15 CRDT- 2026/07/15 11:04 PHST- 2026/02/07 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/06/22 00:00 [revised] PHST- 2026/07/15 12:36 [medline] PHST- 2026/07/15 12:35 [pubmed] PHST- 2026/07/15 11:04 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.1007/s00431-026-07212-x [pii] AID - 7212 [pii] AID - 10.1007/s00431-026-07212-x [doi] PST - epublish SO - Eur J Pediatr. 2026 Jul 15;185(8):577. doi: 10.1007/s00431-026-07212-x. PMID- 42454980 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260821 IS - 1097-0193 (Electronic) IS - 1065-9471 (Print) IS - 1065-9471 (Linking) VI - 47 IP - 11 DP - 2026 Aug TI - A Discovery and Replication Study of Dyslexia Does Not Reveal Reproducible Gray Matter Volume Differences. PG - e70592 LID - 10.1002/hbm.70592 [doi] LID - e70592 AB - Two decades of research have provided evidence for gray matter volume (GMV) differences in developmental dyslexia (or reading disability, RD) in the left perisylvian cortex. However, there are concerns about result inconsistencies, likely attributable to small sample sizes, lenient statistical thresholds, and insufficient accounting for demographic variables and global GMV. To address these concerns, we conducted a Discovery and Replication Study (N = 262) using data from the Adolescent Brain Cognitive Development(SM) Study. We found GMV differences between the RD and Control Groups did not replicate across the Discovery and Replication Studies using voxel-based morphometry (VBM) in Statistical Parametric Mapping (SPM), and that a more conservative threshold yielded few results. We then conducted Reproducibility Studies and first found that when using surface-based morphometry in FreeSurfer instead of VBM, the Discovery and the Replication Study results again failed to converge. Second, we combined all groups in a factorial VBM/SPM analysis and the interaction analysis provided quantitative confirmation for diverging between-group difference results across the two studies. Third, we tested for the role of covariates of no interest and found that when total GMV is not controlled for, this divergence dissipates and group differences in RD (main effect of Reading Ability) are amplified. In conclusion, replication of GMV differences in RD is low, even when using large, well-matched groups, and analyses approaches play a modulating role. As such, results from prior studies using lenient statistical thresholds and not accounting for total GMV should be viewed with caution. CI - (c) 2026 The Author(s). Human Brain Mapping published by Wiley Periodicals LLC. FAU - Schug, Alison K AU - Schug AK AUID- ORCID: 0000-0001-7760-0547 AD - Center for the Study of Learning, Department of Pediatrics, Georgetown University Medical Center, Washington, District of Columbia, USA. AD - Interdisciplinary Program in Neuroscience, Georgetown University, Washington, District of Columbia, USA. FAU - Gutierrez-Schieferl, Iria S AU - Gutierrez-Schieferl IS AUID- ORCID: 0009-0001-9029-4385 AD - Center for the Study of Learning, Department of Pediatrics, Georgetown University Medical Center, Washington, District of Columbia, USA. AD - Interdisciplinary Program in Neuroscience, Georgetown University, Washington, District of Columbia, USA. FAU - Eden, Guinevere F AU - Eden GF AUID- ORCID: 0000-0002-5942-1497 AD - Center for the Study of Learning, Department of Pediatrics, Georgetown University Medical Center, Washington, District of Columbia, USA. AD - Interdisciplinary Program in Neuroscience, Georgetown University, Washington, District of Columbia, USA. LA - eng GR - U24 DA041147/DA/NIDA NIH HHS/United States GR - U01 DA051039/DA/NIDA NIH HHS/United States GR - U01 DA041120/DA/NIDA NIH HHS/United States GR - U01 DA041093/DA/NIDA NIH HHS/United States GR - U01 DA051038/DA/NIDA NIH HHS/United States GR - U01 DA041106/DA/NIDA NIH HHS/United States GR - U01 DA041148/DA/NIDA NIH HHS/United States GR - Z01 DA000510/ImNIH/Intramural NIH HHS/United States GR - U01 DA041174/DA/NIDA NIH HHS/United States GR - T32 DC019481/DC/NIDCD NIH HHS/United States GR - U24 DA041123/DA/NIDA NIH HHS/United States GR - U01 DA041134/DA/NIDA NIH HHS/United States GR - TL1 TR001431/NH/NIH HHS/United States GR - U01 DA041022/DA/NIDA NIH HHS/United States GR - R01 HD081078/NH/NIH HHS/United States GR - U01 DA041156/DA/NIDA NIH HHS/United States GR - U01 DA050987/DA/NIDA NIH HHS/United States GR - U01 DA051037/DA/NIDA NIH HHS/United States GR - TL1 TR001431/TR/NCATS NIH HHS/United States GR - U01 DA051016/DA/NIDA NIH HHS/United States GR - R01 HD081078/HD/NICHD NIH HHS/United States GR - U01 DA041025/DA/NIDA NIH HHS/United States GR - U01 DA050989/DA/NIDA NIH HHS/United States GR - T32 DC019481/NH/NIH HHS/United States GR - U01 DA041089/DA/NIDA NIH HHS/United States GR - U01 DA050988/DA/NIDA NIH HHS/United States GR - 1743521/National Science Foundation/ GR - U01 DA041117/DA/NIDA NIH HHS/United States GR - U01 DA041028/DA/NIDA NIH HHS/United States GR - U01 DA041048/DA/NIDA NIH HHS/United States PT - Journal Article PL - United States TA - Hum Brain Mapp JT - Human brain mapping JID - 9419065 SB - IM UOF - bioRxiv. 2026 May 07:2026.05.05.722925. doi: 10.64898/2026.05.05.722925. PMID: 42146405 MH - Humans MH - *Dyslexia/pathology/diagnostic imaging MH - *Gray Matter/pathology/diagnostic imaging MH - Magnetic Resonance Imaging MH - Reproducibility of Results MH - Female MH - Male MH - Adolescent MH - Image Processing, Computer-Assisted MH - *Brain/pathology/diagnostic imaging MH - Organ Size PMC - PMC13371619 OTO - NOTNLM OT - dyslexia OT - gray matter volume discovery and replication study OT - reading disability COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 12:37 MHDA- 2026/07/15 18:40 PMCR- 2026/07/15 CRDT- 2026/07/15 09:43 PHST- 2026/06/04 00:00 [revised] PHST- 2025/12/06 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/07/15 18:40 [medline] PHST- 2026/07/15 12:37 [pubmed] PHST- 2026/07/15 09:43 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - HBM70592 [pii] AID - 10.1002/hbm.70592 [doi] PST - ppublish SO - Hum Brain Mapp. 2026 Aug;47(11):e70592. doi: 10.1002/hbm.70592. PMID- 42454963 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1752-8984 (Electronic) IS - 1479-1641 (Print) IS - 1479-1641 (Linking) VI - 23 IP - 4 DP - 2026 Jul-Aug TI - Body composition rather than liver fat associates with carotid Intima-Media thickness in youth with type 1 diabetes. PG - 14791641261470422 LID - 10.1177/14791641261470422 [doi] LID - 14791641261470422 AB - IntroductionMetabolic dysfunction-associated steatotic liver disease (MASLD) is a recognized cardiometabolic risk factor in adults, but its relevance to early vascular remodeling in youth with type 1 diabetes (T1D) remains unclear. We evaluated the independent associations of hepatic fat and body composition with early structural vascular remodeling in youth with T1D.MethodsThis cross-sectional study included 49 late-pubertal youth with T1D (mean age 16.1+/-2.6 years; duration 7.5+/-4.3 years). Hepatic fat was quantified using MRI-proton density fat fraction (PDFF), while body composition and estimated insulin sensitivity (eIS) were assessed using dual-energy X-ray absorptiometry and a validated pediatric equation. Carotid intima-media thickness (cIMT), measured by ultrasound, served as the primary outcome. Hierarchical linear regression assessed independent associations after adjustment for age, sex, and diabetes duration.ResultsMean hepatic fat was 1.87+/-1.22%, with no participants meeting criteria for steatosis. Hepatic fat, eIS, and diabetes duration were not associated with cIMT. Lean body mass was the primary independent associate of cIMT (beta=0.44, p=0.02). Although eIS was strongly associated with waist circumference (r=-0.76, p<0.001), neither variable was associated with cIMT.ConclusionsIn this sub-steatotic cohort, cIMT was primarily associated with lean body mass, reflecting physiologic growth, while central adiposity was associated with metabolic dysfunction but not vascular structure. FAU - Tas, Emir AU - Tas E AUID- ORCID: 0000-0003-3759-2778 AD - Pediatric Endocrinology and Diabetes, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA. AD - Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA. RINGGOLD: 6614 FAU - Gumus, Memduha AU - Gumus M AD - Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA. RINGGOLD: 6614 AD - Pediatric Radiology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA. FAU - Movva, Swetha AU - Movva S AD - Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA. RINGGOLD: 6614 FAU - Mendizabal, Brenda AU - Mendizabal B AD - Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA. RINGGOLD: 6614 AD - Pediatric Cardiology, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA. FAU - Barinas-Mitchell, Emma AU - Barinas-Mitchell E AD - Epidemiology, University of Pittsburgh, Pittsburgh, PA, USA. RINGGOLD: 6614 FAU - Gong, Zhenwei AU - Gong Z AD - Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA. RINGGOLD: 6614 FAU - Dranoff, Jonathan A AU - Dranoff JA AD - Department of Medicine, Yale University, New Haven, CT, USA. RINGGOLD: 12228 AD - Steatotic Liver Disease Program, VA Connecticut Healthcare System, New Haven, CT, USA. RINGGOLD: 628143 FAU - Muzumdar, Radhika AU - Muzumdar R AD - Pediatric Endocrinology and Diabetes, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA. AD - Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA. RINGGOLD: 6614 FAU - Libman, Ingrid AU - Libman I AD - Pediatric Endocrinology and Diabetes, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA, USA. AD - Department of Pediatrics, University of Pittsburgh, Pittsburgh, PA, USA. RINGGOLD: 6614 LA - eng PT - Journal Article DEP - 20260715 PL - England TA - Diab Vasc Dis Res JT - Diabetes & vascular disease research JID - 101234011 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/diagnosis/complications/physiopathology MH - Cross-Sectional Studies MH - Female MH - Adolescent MH - Male MH - *Carotid Intima-Media Thickness MH - *Adiposity MH - *Liver/diagnostic imaging/physiopathology MH - Insulin Resistance MH - *Carotid Artery Diseases/diagnostic imaging/etiology/physiopathology MH - Risk Factors MH - *Vascular Remodeling MH - Age Factors MH - Absorptiometry, Photon MH - Magnetic Resonance Imaging MH - Child MH - *Fatty Liver/physiopathology/diagnostic imaging MH - *Body Composition MH - Predictive Value of Tests PMC - PMC13373370 OTO - NOTNLM OT - MRI-PDFF OT - adiposity OT - body composition OT - carotid intima-media thickness OT - insulin resistance OT - type 1 diabetes COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/07/15 12:37 MHDA- 2026/07/15 12:38 PMCR- 2026/07/15 CRDT- 2026/07/15 09:33 PHST- 2026/07/15 12:38 [medline] PHST- 2026/07/15 12:37 [pubmed] PHST- 2026/07/15 09:33 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.1177_14791641261470422 [pii] AID - 10.1177/14791641261470422 [doi] PST - ppublish SO - Diab Vasc Dis Res. 2026 Jul-Aug;23(4):14791641261470422. doi: 10.1177/14791641261470422. Epub 2026 Jul 15. PMID- 42453669 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260715 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Impact of metabolic score for visceral fat on bone health in adolescent population: a cross-sectional study perspective. PG - 1822235 LID - 10.3389/fnut.2026.1822235 [doi] LID - 1822235 AB - OBJECTIVE: To analyze the relationship between the Metabolic Score for Visceral Fat (METS-VF), bone mineral content (BMC), and bone metabolism indexes in Chinese adolescents. METHODS: This cross-sectional study used stratified cluster sampling to select 1,206 adolescents (12-18 years) from six schools in Yinchuan (2017-2023). Body composition and BMC of the participants were measured using bioelectrical impedance analysis (BIA). Serum bone metabolism indexes [osteocalcin (OC) and C-terminal telopeptide of type I collagen (CTX)] were measured. RESULTS: METS-VF was found to be associated with BMC (r = 0.484, P < 0.001) and OC (r = -0.074, P = 0.010), but not with CTX (r = 0.042, P = 0.141). After adjusting for confounding factors, compared with the lowest quartile of METS-VF, the risk of low BMC in the highest quartile was significantly lower, with an OR of 0.17 (95% CI: 0.05-0.49), whereas the risk of low OC was significantly higher, with an OR of 3.47 (95% CI: 1.82-6.59) (all P < 0.05). In sex-stratified analyses, this association was significant in both boys and girls (OR(boys) = 0.03, 95% CI: 0.01-0.46, P = 0.007; OR(girls) = 0.20, 95% CI: 0.06-0.64, P = 0.005). Restricted cubic spline curves indicated that there was an inverted U-shaped non-linear relationship between METS-VF and BMC (P-overall = 0.002, P-nonlinear = 0.009). In sex-stratified analyses, the association was significant in girls (P-nonlinear = 0.152; P-overall = 0.008); Moreover, linear relationship between METS-VF and OC were found (P nonlinear = 0.162, P-overall <0.05). Receiver operating characteristic (ROC) curves showed that METS-VF had modest discriminatory ability for low BMC better than VAI and TyG (AUC = 0.641, 95% CI = 0.605-0.678, P < 0.05). CONCLUSION: Our findings suggest a non-linear association between METS-VF and BMC in adolescents, and fat distribution and content were more closely related to bone metabolism. CI - Copyright (c) 2026 Chen, Liu, Shi, Xu and Ding. FAU - Chen, Linlin AU - Chen L AD - School of Public Health, Ningxia Medical University, Yinchuan, China. AD - Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, China. FAU - Liu, Jianxi AU - Liu J AD - School of Public Health, Ningxia Medical University, Yinchuan, China. AD - Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, China. FAU - Shi, Longkai AU - Shi L AD - School of Public Health, Ningxia Medical University, Yinchuan, China. AD - Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, China. FAU - Xu, Yingli AU - Xu Y AD - School of Public Health, Ningxia Medical University, Yinchuan, China. AD - Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, China. FAU - Ding, Wenqing AU - Ding W AD - School of Public Health, Ningxia Medical University, Yinchuan, China. AD - Key Laboratory of Environmental Factors and Chronic Disease Control, Yinchuan, China. LA - eng PT - Journal Article DEP - 20260630 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13365040 OTO - NOTNLM OT - adolescents OT - bone metabolism markers OT - bone mineral content OT - osteoporosis OT - the metabolic score for visceral fat COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/15 10:10 MHDA- 2026/07/15 10:11 PMCR- 2026/06/30 CRDT- 2026/07/15 04:50 PHST- 2026/03/03 00:00 [received] PHST- 2026/05/31 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/07/15 10:11 [medline] PHST- 2026/07/15 10:10 [pubmed] PHST- 2026/07/15 04:50 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - 10.3389/fnut.2026.1822235 [doi] PST - epublish SO - Front Nutr. 2026 Jun 30;13:1822235. doi: 10.3389/fnut.2026.1822235. eCollection 2026. PMID- 42453435 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260715 LR - 20260922 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Physical activity and adolescents' parasocial relationships with virtual idols: evidence from loneliness, gender differences, and network analysis. PG - 1854829 LID - 10.3389/fpsyg.2026.1854829 [doi] LID - 1854829 AB - INTRODUCTION: This study aimed to examine whether higher levels of physical activity were associated with adolescents' parasocial relationships with virtual idols through lower levels of loneliness, and to determine whether gender moderated these associations. The study also explored the item-level connections between loneliness and parasocial relationships with virtual idols. METHODS: A cross-sectional survey was conducted among 2,798 adolescents from Sichuan, Hunan, Yunnan, and Chongqing provinces in China. Physical activity, loneliness, and parasocial relationships with virtual idols were measured using validated questionnaires. The SPSS PROCESS macro was used to test the moderated mediation model, and network analysis was conducted to identify key bridging nodes between loneliness and parasocial relationships. RESULTS: Physical activity was significantly negatively associated with parasocial relationships with virtual idols, and loneliness showed a significant partial statistical mediation in this association. Gender significantly moderated both the association between physical activity and loneliness and the association between loneliness and parasocial relationships, with these associations being more pronounced among female adolescents. Network analysis further identified bridging connections between real-life relational deficits, such as feeling neglected and lacking companionship, and emotional involvement with virtual idols, such as caring about the life of a virtual idol. DISCUSSION: The findings suggest that physical activity may be associated with weaker parasocial relationships with virtual idols not only through time occupation or attention diversion, but also through lower loneliness and stronger real-life social connection. Interventions aimed at reducing excessive emotional dependence on virtual idols should therefore focus on promoting physical engagement, real-life interaction, and adolescents' sense of belonging. CI - Copyright (c) 2026 Chen, Lin, Wang, Wang and Xiang. FAU - Chen, Longjiang AU - Chen L AD - Institute of Physical Education, Yunnan Normal University, Kunming, China. FAU - Lin, Ziyang AU - Lin Z AD - School of Sport and Art, Shenzhen Technology University, Shenzhen, China. FAU - Wang, Zeyan AU - Wang Z AD - School of Physical Education, Chengdu University of Technology, Chengdu, China. FAU - Wang, Jiale AU - Wang J AD - College of Physical Education, Xinjiang Normal University, Urumqi, Xinjiang, China. FAU - Xiang, Yian AU - Xiang Y AD - Department of Rehabilitation Medicine, Lishui Municipal Central Hospital, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui, China. LA - eng PT - Journal Article DEP - 20260630 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13365051 OTO - NOTNLM OT - adolescents OT - loneliness OT - network analysis OT - parasocial relationship OT - physical activity OT - virtual idols COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/15 06:38 MHDA- 2026/07/15 06:39 PMCR- 2026/06/30 CRDT- 2026/07/15 04:47 PHST- 2026/04/13 00:00 [received] PHST- 2026/06/07 00:00 [revised] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/07/15 06:39 [medline] PHST- 2026/07/15 06:38 [pubmed] PHST- 2026/07/15 04:47 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1854829 [doi] PST - epublish SO - Front Psychol. 2026 Jun 30;17:1854829. doi: 10.3389/fpsyg.2026.1854829. eCollection 2026. PMID- 42453080 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260904 IS - 1525-1446 (Electronic) IS - 0737-1209 (Print) IS - 0737-1209 (Linking) VI - 43 IP - 5 DP - 2026 Sep-Oct TI - The Urban-Rural Continuum and Child Health: Influence of Residential Location on Ultra-Processed Food Consumption, Physical Activity, and Metabolic Biomarkers. PG - 1180-1189 LID - 10.1111/phn.70156 [doi] AB - OBJECTIVE: This study aimed to investigate the association between residential location-urban area and urban expansion area and sociodemographic characteristics, health behaviors, and clinical-metabolic outcomes among schoolchildren aged 6 to 9 years in the municipality of Rio das Ostras, Brazil. METHODS: This was a cross-sectional study involving 420 students from public municipal schools. Sociodemographic and behavioral data were collected using validated questionnaires (QUADA-3 and QUAFDA). Anthropometric measurements, blood pressure, and biochemical analyses were conducted. Associations were assessed using Pearson's chi-square or Fisher's exact tests and logistic regression models, both crude and adjusted for age, sex, maternal and paternal education, and household income.were estimated with 95% confidence intervals (CI). FINDINGS: Children living in urban expansion areas had lower paternal education levels (p = 0.021) and were less likely to engage in active commuting to school (2.4% vs. 42.6%; p < 0.001). No significant differences were observed in excess weight, physical activity scores, or ultra-processed food consumption between the two groups. However, children from urban expansion areas showed a higher prevalence of prediabetes (OR = 0.133; 95% CI = 0.045-0.358; p < 0.001), elevated total cholesterol (OR = 0.423; p = 0.007), low HDL-c (OR = 0.324; p < 0.001), elevated LDL-c (OR = 0.304; p < 0.001), and elevated triglycerides (OR = 0.484; p = 0.029). CONCLUSIONS: Residing in urban expansion areas was associated with worse clinical-metabolic outcomes among schoolchildren, independent of nutritional status, physical activity, and ultra-processed food consumption. These findings highlight the need for intersectoral and place-based policies to promote healthier environments for children in territories undergoing urbanization. CI - (c) 2026 The Author(s). Public Health Nursing published by Wiley Periodicals LLC. FAU - Rangel, Luiz Felipe da Cruz AU - Rangel LFDC AUID- ORCID: 0000-0001-5513-0011 AD - Laboratory of Research and Innovation in Sports Science and Nutrition, Federal University of Rio de Janeiro, Macae, Brazil. AD - Josue de Castro Institute of NutritionFederal University of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro, Macae, Brazil. AD - Higher Institutes of Education of CENSA, ISECENSA, Campos dos Goytacazes, Brazil. FAU - Silva, Cynthia Goncalves AU - Silva CG AD - Laboratory of Research and Innovation in Sports Science and Nutrition, Federal University of Rio de Janeiro, Macae, Brazil. AD - Josue de Castro Institute of NutritionFederal University of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro, Macae, Brazil. FAU - de Matos, Alessandra Alegre AU - de Matos AA AUID- ORCID: 0000-0001-7938-4198 AD - Laboratory of Research and Innovation in Sports Science and Nutrition, Federal University of Rio de Janeiro, Macae, Brazil. AD - Josue de Castro Institute of NutritionFederal University of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro, Macae, Brazil. FAU - Teixeira, Francisco Martins AU - Teixeira FM AUID- ORCID: 0000-0003-0640-5570 AD - Macae Campus, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Ribeiro, Beatriz Goncalves AU - Ribeiro BG AD - Laboratory of Research and Innovation in Sports Science and Nutrition, Federal University of Rio de Janeiro, Macae, Brazil. AD - Josue de Castro Institute of NutritionFederal University of Rio de Janeiro, Federal University of Rio de Janeiro, Rio de Janeiro, Macae, Brazil. AD - Macae Campus, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. LA - eng PT - Journal Article PT - Review DEP - 20260715 PL - United States TA - Public Health Nurs JT - Public health nursing (Boston, Mass.) JID - 8501498 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Brazil MH - Cross-Sectional Studies MH - *Urban Population/statistics & numerical data MH - *Rural Population/statistics & numerical data MH - *Exercise MH - *Child Health/statistics & numerical data MH - Biomarkers/blood/analysis MH - *Fast Foods/statistics & numerical data MH - *Residence Characteristics/statistics & numerical data MH - Health Behavior MH - Socioeconomic Factors PMC - PMC13535876 OTO - NOTNLM OT - child health OT - health inequalities OT - pediatric dyslipidemia OT - physical activity OT - ultra-processed foods OT - urbanization EDAT- 2026/07/15 06:37 MHDA- 2026/09/02 11:39 PMCR- 2026/09/02 CRDT- 2026/07/15 04:42 PHST- 2025/11/05 00:00 [revised] PHST- 2025/09/03 00:00 [received] PHST- 2026/06/25 00:00 [accepted] PHST- 2026/09/02 11:39 [medline] PHST- 2026/07/15 06:37 [pubmed] PHST- 2026/07/15 04:42 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - PHN70156 [pii] AID - 10.1111/phn.70156 [doi] PST - ppublish SO - Public Health Nurs. 2026 Sep-Oct;43(5):1180-1189. doi: 10.1111/phn.70156. Epub 2026 Jul 15. PMID- 42452888 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260828 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 3 DP - 2026 Jul TI - A Growing Problem: Increases in Child-Appealing Marketing on Infant and Young Children's Foods in Australia (2015 vs 2024). PG - e70226 LID - 10.1111/mcn.70226 [doi] LID - e70226 AB - Commercial foods for infants and young children are widely available and often introduced early, including before 6 months, raising concerns about their often high levels of sugar and sodium, limited micronutrient content, and sweet flavours that may shape future taste preferences. Product packaging further influences caregiver choices through child-appealing images and claims. This study examined changes in child-appealing marketing appearing on packaged commercial infant and young children's foods available in Australia in 2015 (n = 311) and 2024 (n = 298). Products were coded using a validated framework comprising 11 core techniques (child-targeted, e.g., bright colours, cartoon characters, fun themes) and 9 broad techniques (caregiver-targeted, e.g., nutrition/health, texture claims). Marketing power was calculated as the sum of techniques per product. The proportion of products featuring child-appealing marketing increased from 73.0% in 2015 to 89.9% in 2024, with significant increases in appeals to fun (48.2% to 79.2%), branded characters (33.8% to 62.4%), and child-appealing visuals on the package (60.5% to 72.5%). Claims regarding texture were high in both years (99.7% in 2015 and 100.0% in 2024), and there was a notable growth in messages promoting value, convenience, or sustainability (from 50.2% to 62.1%). Marketing power scores rose significantly over time, indicating an intensification of persuasive techniques on packaging. These findings highlight systemic commercial strategies that promote nutritionally poor foods to infants, young children and caregivers, undermining public health efforts. Stronger, government-led regulation is urgently needed to address the widespread use of both child-targeted and caregiver-targeted marketing on commercial foods for infants and young children. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Arfines, Prisca Petty AU - Arfines PP AUID- ORCID: 0000-0002-5118-7536 AD - Food Policy Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia. FAU - Coyle, Daisy AU - Coyle D AUID- ORCID: 0000-0001-8904-0671 AD - Food Policy Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia. FAU - Barrett, Eden AU - Barrett E AD - Food Policy Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia. FAU - McCann, Jennifer AU - McCann J AUID- ORCID: 0000-0002-8940-978X AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. FAU - Dunford, Elizabeth AU - Dunford E AD - Food Policy Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia. AD - Department of Nutrition, Gillings Global School of Public Health, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Jones, Alexandra AU - Jones A AUID- ORCID: 0000-0001-5039-144X AD - Food Policy Division, The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Australia MH - Infant MH - *Infant Food MH - *Marketing/trends/methods MH - *Food Preferences MH - Child, Preschool MH - *Food Labeling MH - Food Packaging MH - Nutritive Value MH - Female MH - *Consumer Behavior PMC - PMC13369571 OTO - NOTNLM OT - food analysis OT - food labelling OT - food packaging OT - infant food OT - marketing OT - nutrition labelling OT - processed food COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 06:34 MHDA- 2026/07/15 12:36 PMCR- 2026/07/14 CRDT- 2026/07/15 02:04 PHST- 2026/04/13 00:00 [revised] PHST- 2026/01/22 00:00 [received] PHST- 2026/06/13 00:00 [accepted] PHST- 2026/07/15 12:36 [medline] PHST- 2026/07/15 06:34 [pubmed] PHST- 2026/07/15 02:04 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - MCN70226 [pii] AID - 10.1111/mcn.70226 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jul;22(3):e70226. doi: 10.1111/mcn.70226. PMID- 42452565 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260715 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 13 DP - 2026 Jun 30 TI - Presentation and Clinical Outcomes of Inflammatory Bowel Disease in Children and Adolescents at a Tertiary Care Center in Lebanon. LID - 10.3390/jcm15135105 [doi] LID - 5105 AB - Background: Pediatric-onset inflammatory bowel disease (IBD) is a chronic relapsing condition leading to substantial morbidity and variable disease course. Early recognition of factors associated with suboptimal outcomes may improve risk stratification and therapeutic strategy. This retrospective cohort study intended to analyze the association between initial presentation characteristics and early disease course in pediatric-onset IBD. Methods: Included were pediatric patients diagnosed with Crohn's disease (CD) or ulcerative colitis (UC) followed at the American University of Beirut Medical Center between 2013 and 2023. Demographic, anthropometric, laboratory, endoscopic, radiologic, and clinical data were gathered from medical records. Validated pediatric activity indices were used to assess severity, and early outcomes covered mainly the first remission. Results: Eighty-eight patients were evaluated for baseline characteristics, and eighty-one patients were analyzed for treatment outcomes. Among 88 subjects, 62.5% had CD and 37.5% had UC, with a mean age at diagnosis of 11.29 (+/-4.60) years. The most encountered presenting symptoms were abdominal pain, diarrhea, and hematochezia, with 44.9% of subjects having malnutrition. Clinical remission after initial treatment was obtained in 60.2% of subjects. A past medical history of autoimmune or inflammatory disease was linked to persistent symptoms, whereas initial use of corticosteroids was associated with early clinical remission. Conclusions: Pediatric IBD in our cohort was marked by extensive disease involvement, high inflammatory burden, nutritional impairment, and frequent flare or treatment escalation. Corticosteroid initiation at diagnosis was associated with early clinical remission in this retrospective cohort. Nevertheless, this association should be interpreted cautiously, as the retrospective design and potential confounding by indication limit any inference regarding causality or treatment superiority. The high rate of subsequent flare underscores the need for early risk stratification and individualized multidisciplinary care to improve long-term outcomes. FAU - Daoud, Tracy AU - Daoud T AD - Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut 1107, Lebanon. FAU - Khafaja, Sarah AU - Khafaja S AD - Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut 1107, Lebanon. FAU - Hanna-Wakim, Rima AU - Hanna-Wakim R AUID- ORCID: 0000-0002-8870-2159 AD - Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut 1107, Lebanon. AD - Division of Pediatric Infectious Diseases, Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut 1107, Lebanon. FAU - Yazbeck, Nadine AU - Yazbeck N AUID- ORCID: 0000-0002-2325-4113 AD - Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut 1107, Lebanon. AD - Division of Pediatric Gastroenterology and Nutrition, Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut 1107, Lebanon. LA - eng PT - Journal Article DEP - 20260630 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13362712 OTO - NOTNLM OT - Crohn's disease OT - clinical remission OT - disease severity OT - pediatric inflammatory bowel disease OT - ulcerative colitis COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 10:10 MHDA- 2026/07/15 10:11 PMCR- 2026/06/30 CRDT- 2026/07/15 01:09 PHST- 2026/05/19 00:00 [received] PHST- 2026/06/27 00:00 [revised] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/07/15 10:11 [medline] PHST- 2026/07/15 10:10 [pubmed] PHST- 2026/07/15 01:09 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - jcm15135105 [pii] AID - jcm-15-05105 [pii] AID - 10.3390/jcm15135105 [doi] PST - epublish SO - J Clin Med. 2026 Jun 30;15(13):5105. doi: 10.3390/jcm15135105. PMID- 42451409 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 13 DP - 2026 Jul 2 TI - A Multi-Stage Framework for Refining Infant Daytime Sleep-Wake Labels from Wearable Accelerometer Data. LID - 10.3390/s26134168 [doi] LID - 4168 AB - Sleep is essential for infants' physical and cognitive development. Unlike older children or adolescents, infants sleep longer durations, including multiple daytime naps. While nighttime sleep is easier to detect due to its extended periods, identifying daytime sleep is more challenging due to its short, fragmented nature and its similarity to idle wakefulness. Moreover, parent-reported sleep estimations are prone to error as continuous monitoring is often impractical. To address these limitations, we developed a Multi-Stage Sleep-Wake (MSW) classification approach using triaxial accelerometer data collected from wearable devices placed on infants' ankles and waists over multiple days. This method systematically refines and classifies sleep and wake states through a series of analytical steps. This systematic process generates refined proxy sleep-wake labels that account for behavioral overlaps and correct mislabeled idle periods. We trained and validated multiple machine learning models using these labels and compared the results to parent annotated labels. Models trained using MSW-derived labels achieved 96.6% accuracy using Random Forest classifier compared to 72% using parent-reported labels. These findings demonstrate that the MSW framework produces a more consistent set of proxy sleep-wake annotations for model development, although the derived labels were not validated against an independent reference standard. Furthermore, the proposed MSW framework may serve as a practical label-refinement methodology for improving noisy caregiver-reported sleep annotations in future wearable-based infant sleep studies where independent sleep labels are unavailable. FAU - Thelagathoti, Rama Krishna AU - Thelagathoti RK AD - Molecular Diagnostic Research Laboratory, Boys Town National Research Hospital, Omaha, NE 68131, USA. FAU - Redrowthu, Vijaya Saraswathi AU - Redrowthu VS AUID- ORCID: 0000-0002-5462-3030 AD - Department of Computer Science and Engineering, VNR Vignana Jyothi Institute of Engineering and Technology, Hyderabad 500090, Telangana, India. FAU - Dinkel, Danae AU - Dinkel D AUID- ORCID: 0000-0002-0262-4429 AD - School of Health and Kinesiology, University of Nebraska Omaha, Omaha, NE 68182, USA. FAU - Ali, Hesham H AU - Ali HH AUID- ORCID: 0000-0002-8016-6144 AD - College of Information Science and Technology, University of Nebraska Omaha, Omaha, NE 68182, USA. FAU - Fernando, Rohan M AU - Fernando RM AUID- ORCID: 0000-0002-3596-3160 AD - Molecular Diagnostic Research Laboratory, Boys Town National Research Hospital, Omaha, NE 68131, USA. LA - eng GR - PG64311/Ryan Foundation/ PT - Journal Article DEP - 20260702 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Wearable Electronic Devices MH - Infant MH - *Accelerometry/methods MH - *Wakefulness/physiology MH - *Sleep/physiology MH - Machine Learning MH - Female MH - Male PMC - PMC13363950 OTO - NOTNLM OT - actigraphy data analysis OT - infant sleep detection OT - label refinement OT - wearable accelerometers COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 06:34 MHDA- 2026/07/15 13:09 PMCR- 2026/07/02 CRDT- 2026/07/15 01:06 PHST- 2026/04/24 00:00 [received] PHST- 2026/06/24 00:00 [revised] PHST- 2026/06/27 00:00 [accepted] PHST- 2026/07/15 13:09 [medline] PHST- 2026/07/15 06:34 [pubmed] PHST- 2026/07/15 01:06 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - s26134168 [pii] AID - sensors-26-04168 [pii] AID - 10.3390/s26134168 [doi] PST - epublish SO - Sensors (Basel). 2026 Jul 2;26(13):4168. doi: 10.3390/s26134168. PMID- 42451245 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 13 DP - 2026 Jun 24 TI - Automated Anxiety Detection System Integrating a Brain-Computer Interface for Neurofeedback Applications. LID - 10.3390/s26134004 [doi] LID - 4004 AB - Anxiety disorders pose an increasing challenge to the mental health of individuals, particularly in regions with limited healthcare access. This study investigated the potential of integrating a brain-computer interface for processing electroencephalography (EEG) data with deep learning models to accurately classify anxious and non-anxious states. In the first phase, a convolutional neural network (CNN) was developed and validated on the public GAMEEMO dataset, achieving a classification accuracy of 95.72%. In the second phase, we conducted a separate experimental validation with seven participants (aged 18-60 years) using a within-subjects design. The protocol comprised a custom Stroop test to elicit acute cognitive stress and anxiety-related arousal, followed by a guided 4-7-8 breathing exercise to induce relaxation. EEG data from this experiment were used to classify anxious versus non-anxious states with the same CNN architecture after domain adaptation. On this self-collected dataset, the CNN achieved an accuracy of 86.58%. These results demonstrate proof-of-concept transferability while highlighting the performance gap between controlled benchmark data and real-world, small-sample recordings. The deep learning model can subsequently be coupled with neurofeedback techniques to manage anxiety levels. Overall, the findings support the potential of the developed automated system for detecting stress-induced anxious states, with possible future integration into neurofeedback-based management systems. FAU - Aldayel, Mashael AU - Aldayel M AUID- ORCID: 0000-0001-6054-4534 AD - Information Technology Department, College of Computer and Information Sciences, King Saud University, Riyadh 11543, Saudi Arabia. FAU - Al-Nafjan, Abeer AU - Al-Nafjan A AUID- ORCID: 0000-0003-4186-9805 AD - Computer Science Department, College of Computer and Information Sciences, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh 11432, Saudi Arabia. LA - eng GR - IMSIU-DDRSP2604/Imam Mohammad ibn Saud Islamic University/ PT - Journal Article DEP - 20260624 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Brain-Computer Interfaces MH - Electroencephalography/methods MH - *Neurofeedback/methods MH - Convolutional Neural Networks MH - Adult MH - *Anxiety/diagnosis/physiopathology MH - Middle Aged MH - Female MH - Deep Learning MH - Male MH - Adolescent MH - Young Adult PMC - PMC13363975 OTO - NOTNLM OT - anxiety OT - brain-computer interface OT - deep learning OT - electroencephalography OT - neurofeedback COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 06:35 MHDA- 2026/07/15 13:09 PMCR- 2026/06/24 CRDT- 2026/07/15 01:05 PHST- 2026/04/03 00:00 [received] PHST- 2026/06/16 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/15 13:09 [medline] PHST- 2026/07/15 06:35 [pubmed] PHST- 2026/07/15 01:05 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - s26134004 [pii] AID - sensors-26-04004 [pii] AID - 10.3390/s26134004 [doi] PST - epublish SO - Sensors (Basel). 2026 Jun 24;26(13):4004. doi: 10.3390/s26134004. PMID- 42451177 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 13 DP - 2026 Jul 4 TI - Trans Fatty Acids Content in Breast Milk as a Marker of Their Short-Term Intake Within the Breastfeeding Mother's Diet: A Single-Participant Pilot Study. LID - 10.3390/nu18132177 [doi] LID - 2177 AB - Introduction: Breast milk is the best food for a growing infant during the first 6 months of life. The presence of trans fatty acids (TFAs) in breast milk can interfere with the synthesis of long-chain polyunsaturated fatty acids (LC-PUFAs), increasing the risk of developing, among other issues, asthma or atopic dermatitis. TFAs are not synthesised de novo in the human body. Their content in breast milk may be a good marker of short-term dietary intake of these compounds by breastfeeding mothers. However, the literature shows differences in the assessment of the relationship between dietary TFAs intake and TFAs content in breast milk. Furthermore, the decrease in the TFAs content in food observed recently seems to make it impossible to use Craig-Schmidt's formula to estimate the TFAs content in the diet or in breast milk. The aim of this study was to confirm the possibility of using TFAs content in breast milk as a marker of their short-term intake within the breastfeeding mother's diet, together with an attempt at preliminary quantitative determination of the relationship between these parameters. Materials: The study material was collected from a single breastfeeding mother and included 10 breast milk samples and 10 samples of daily food rations reconstructed based on the 24 h food consumption survey. Methods: The content of fatty acids, including TFAs, was determined by gas chromatography-mass spectrometry (GC-MS). Results: The TFAs content in the whole-day mother's diet and in 100 mL of breast milk ranged from 0.11 to 0.54 g/day and from 0.02 to 0.07 g, respectively. A strong statistically significant (p < 0.05) positive correlation between these parameters was found. Equations for an exploratory linear relationship between the TFAs content in a breastfeeding mother's diet and the concentration of these fatty acids in breast milk have been developed. Due to the small number of samples, these data should be interpreted very cautiously and validated in a larger cohort. Conclusions: This single-participant pilot study suggests that TFAs content in breast milk may be a marker of the dietary intake of these compounds from the previous day. It seems that the dietary habits of breastfeeding mothers of twins are a significant factor influencing the composition of breast milk and, consequently, the nutritional quality of breastfed infants. FAU - Jasinska-Melon, Edyta AU - Jasinska-Melon E AUID- ORCID: 0000-0003-1697-5462 AD - Department of Nutrition and Nutritive Value of Food, National Institute of Public Health NIH-National Research Institute, Chocimska Str. 24, 00-791 Warsaw, Poland. FAU - Mojska, Hanna AU - Mojska H AUID- ORCID: 0000-0002-4093-6159 AD - Department of Nutrition and Nutritive Value of Food, National Institute of Public Health NIH-National Research Institute, Chocimska Str. 24, 00-791 Warsaw, Poland. FAU - Bzikowska-Jura, Agnieszka AU - Bzikowska-Jura A AUID- ORCID: 0000-0001-5181-3771 AD - Department of Clinical Dietetics, Faculty of Health Sciences, Medical University of Warsaw, Ciolka Str. 27, 01-445 Warsaw, Poland. LA - eng GR - 1/FZML/2023 and S.1.FZ.2.26/National Institute of Public Health NIH-National Research Institute/ PT - Journal Article DEP - 20260704 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) RN - 0 (Trans Fatty Acids) SB - IM MH - Humans MH - *Milk, Human/chemistry MH - Female MH - Pilot Projects MH - *Breast Feeding MH - Biomarkers/analysis MH - *Trans Fatty Acids/analysis MH - *Diet MH - Adult MH - Infant PMC - PMC13363609 OTO - NOTNLM OT - GC-MS OT - a 10-day reconstructed daily diet OT - breast milk OT - breastfeeding twins OT - correlations OT - trans fatty acids COIS- The authors declare no conflict of interest. EDAT- 2026/07/15 06:35 MHDA- 2026/07/15 18:40 PMCR- 2026/07/04 CRDT- 2026/07/15 01:05 PHST- 2026/05/15 00:00 [received] PHST- 2026/06/27 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/07/15 18:40 [medline] PHST- 2026/07/15 06:35 [pubmed] PHST- 2026/07/15 01:05 [entrez] PHST- 2026/07/04 00:00 [pmc-release] AID - nu18132177 [pii] AID - nutrients-18-02177 [pii] AID - 10.3390/nu18132177 [doi] PST - epublish SO - Nutrients. 2026 Jul 4;18(13):2177. doi: 10.3390/nu18132177. PMID- 42451103 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 13 DP - 2026 Jun 27 TI - Health-Related Quality of Life in Pediatric Hepatic Glycogen Storage Disease: A Dual-Perspective Study. LID - 10.3390/nu18132099 [doi] LID - 2099 AB - Background/Objectives: Hepatic glycogen storage diseases (GSDs) are rare inherited metabolic disorders requiring lifelong nutritional management and strict metabolic control, which may adversely affect the health-related quality of life (HRQoL). This study aimed to evaluate the HRQoL in children with hepatic GSD using both child and parent reports, compare findings with normative data, and explore associations with biochemical, anthropometric, and nutritional management-related parameters. Methods: The study included 23 children with hepatic GSD and their parents. HRQoL was assessed using the Pediatric Quality of Life Inventory (PedsQL) Generic Core Scale. Child and parent reports were compared with normative data for healthy and chronically ill children. Agreement between child and parent reports was evaluated with intraclass correlation coefficients, and exploratory associations between variables were assessed using partial Spearman correlation analyses. Results: Total and most subscale PedsQL scores reported by both children and parents were significantly lower than those of healthy peers and children with chronic diseases (p < 0.05). Parents reported lower HRQoL scores than children, particularly in psychosocial, social, and school functioning domains, with low to moderate agreement between reports. Exploratory analyses suggested that body composition and nutritional treatment burden indicators were correlated with selected HRQoL domains. Conclusions: Children with hepatic GSD experience impaired HRQoL from both child and parent perspectives. Integrating HRQoL assessment into routine clinical and nutritional follow-up may help identify unmet psychosocial and dietary support needs and support more individualized nutritional management in children with hepatic GSD. FAU - Aydin, Oznur AU - Aydin O AUID- ORCID: 0000-0001-8463-6660 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06100, Turkiye. FAU - Dagdelen, Selcuk AU - Dagdelen S AUID- ORCID: 0000-0002-0513-1750 AD - Division of Endocrinology and Metabolism, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara 06230, Turkiye. FAU - Ozen, Hasan AU - Ozen H AUID- ORCID: 0000-0002-9063-3893 AD - Division of Pediatrics, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara 06230, Turkiye. FAU - Gokmen-Ozel, Hulya AU - Gokmen-Ozel H AUID- ORCID: 0000-0002-8282-6468 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06100, Turkiye. LA - eng GR - 2211/A/Turkiye Bilimsel ve Teknolojik Arastirma Kurumu/ PT - Journal Article DEP - 20260627 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - Hepatorenal form of glycogen storage disease SB - IM MH - Humans MH - *Quality of Life MH - Male MH - Female MH - Child MH - Parents/psychology MH - Child, Preschool MH - *Glycogen Storage Disease/psychology MH - Adolescent MH - Nutritional Status MH - *Glycogen Storage Disease Type I/psychology PMC - PMC13364485 OTO - NOTNLM OT - body composition OT - nutritional management OT - parent-proxy report OT - pediatric quality of life inventory OT - uncooked cornstarch COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 06:36 MHDA- 2026/07/15 18:42 PMCR- 2026/06/27 CRDT- 2026/07/15 01:05 PHST- 2026/05/22 00:00 [received] PHST- 2026/06/21 00:00 [revised] PHST- 2026/06/25 00:00 [accepted] PHST- 2026/07/15 18:42 [medline] PHST- 2026/07/15 06:36 [pubmed] PHST- 2026/07/15 01:05 [entrez] PHST- 2026/06/27 00:00 [pmc-release] AID - nu18132099 [pii] AID - nutrients-18-02099 [pii] AID - 10.3390/nu18132099 [doi] PST - epublish SO - Nutrients. 2026 Jun 27;18(13):2099. doi: 10.3390/nu18132099. PMID- 42451061 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 13 DP - 2026 Jun 24 TI - Potential of Breast Milk Exosomes in Modulating Infant Developmental Programming: A Multi-Omics Study Based on a Birth Cohort. LID - 10.3390/nu18132058 [doi] LID - 2058 AB - BACKGROUND: Human breast milk (HBM), as the initial food for humans, is quite essential for infant development and also for health throughout the lifespan. Exosomes are bioactive components in HBM, yet their nutritional role remains poorly recognized. OBJECTIVES: This study investigates how HBM exosomes change with lactation and their potential role in infant growth and development. METHODS: HBM samples were obtained at 2 and 6 months postpartum from a well-established birth cohort. Purified exosomes were detected using transcriptomic, lipidomic, and proteomic approaches. Then, multi-omics data were analyzed to compare differentially expressed miRNAs, lipids, and proteins along with different lactation periods and their association with the infant growth process. RESULTS: Compared with the 2-month postpartum group, the expression levels of miR-214-3p, miR-199a-5p, miR-126-3p, miR-127-5p, miR-144-3p, and miR-4787-5p were down-regulated in the 6-month postpartum group. In addition, 190 lipids and 269 proteins were up-regulated in the 6-month postpartum group, whereas 15 lipids and 244 proteins were down-regulated. Enrichment analysis revealed that the predicted target genes of differentially expressed miRNAs were primarily involved in cell communication and axon guidance. In parallel, the differentially expressed proteins were enriched in biosynthesis of unsaturated fatty acids and fatty acid metabolism pathway, implying a potential role in adipogenesis and neurodevelopment. CONCLUSIONS: This study reveals that the cargo contents of HBM exosomes change with the lactation period and may adapt to the needs of infant growth and development, particularly adipogenesis and neurodevelopment. HBM exosomes may play an important role in transferring genetic information from mothers to infants and be related to infants' development. The underlying mechanisms warrant further investigation and validation. FAU - Lyu, Ying AU - Lyu Y AUID- ORCID: 0009-0001-4852-794X AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100083, China. FAU - Zhou, Yalin AU - Zhou Y AUID- ORCID: 0000-0002-9085-1487 AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100083, China. AD - PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development, Beijing 100083, China. FAU - Zhu, Xiaoyu AU - Zhu X AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100083, China. FAU - Han, Muke AU - Han M AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100083, China. FAU - Ye, Wanyun AU - Ye W AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100083, China. FAU - Wei, Qiaosi AU - Wei Q AUID- ORCID: 0009-0000-9433-8720 AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100083, China. FAU - Jiang, Shilong AU - Jiang S AUID- ORCID: 0000-0001-6975-0844 AD - PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development, Beijing 100083, China. AD - Feihe Research Institute, Heilongjiang Feihe Dairy Co., Ltd., Beijing 100016, China. FAU - Li, Kaifeng AU - Li K AD - PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development, Beijing 100083, China. AD - Feihe Research Institute, Heilongjiang Feihe Dairy Co., Ltd., Beijing 100016, China. FAU - Xu, Yajun AU - Xu Y AUID- ORCID: 0000-0001-5791-4629 AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, Beijing 100083, China. AD - PKUHSC-China Feihe Joint Research Institute of Nutrition and Healthy Lifespan Development, Beijing 100083, China. LA - eng GR - 2022YFD2101505/National Key Research and Development Program of China/ PT - Journal Article DEP - 20260624 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (MicroRNAs) SB - IM MH - Humans MH - *Exosomes/metabolism MH - *Milk, Human/metabolism/chemistry MH - Female MH - Multiomics MH - Infant MH - MicroRNAs/metabolism/genetics MH - *Child Development/physiology MH - Lactation/metabolism MH - Birth Cohort MH - Proteomics MH - Adult MH - Infant, Newborn PMC - PMC13362560 OTO - NOTNLM OT - adipogenesis OT - exosome OT - human breast milk OT - multi-omics OT - neurodevelopment COIS- Author Shilong Jiang and Kaifeng Li was employed by the company Feihe Research Institute Heilongjiang Feihe Dairy Co., Ltd. They participated in project administration in the study. The role of the company was recruiting participants and providing equipments storing collected human milk. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/15 10:10 MHDA- 2026/07/15 18:42 PMCR- 2026/06/24 CRDT- 2026/07/15 01:05 PHST- 2026/05/06 00:00 [received] PHST- 2026/06/14 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/15 18:42 [medline] PHST- 2026/07/15 10:10 [pubmed] PHST- 2026/07/15 01:05 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - nu18132058 [pii] AID - nutrients-18-02058 [pii] AID - 10.3390/nu18132058 [doi] PST - epublish SO - Nutrients. 2026 Jun 24;18(13):2058. doi: 10.3390/nu18132058. PMID- 42451050 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 13 DP - 2026 Jun 23 TI - Extending the Validity of the Feeding Practices and Structure Questionnaire Solid Feeding Version (FPSQ-S) to Mothers and Fathers Living with Socioeconomic Disadvantage. LID - 10.3390/nu18132046 [doi] LID - 2046 AB - Background/Objective: Parental feeding practices play an important role in shaping children's dietary intake, eating behaviours, and long-term health outcomes. Although several questionnaires assess feeding practices, few have been validated among socioeconomically disadvantaged populations, despite these groups being disproportionately affected by food insecurity and diet-related health inequities. This study assessed the structural validity and internal consistency of the Feeding Practices and Structure Questionnaire-Solid Feeding version (FPSQ-S)-among socioeconomically disadvantaged mothers and fathers of young children. Methods: Two cross-sectional online surveys were conducted with 178 mothers and 94 fathers of children aged 5-35 months living in disadvantaged households. Confirmatory factor analysis was used to examine the structural validity of the FPSQ-S. Internal consistency was assessed using Cronbach's alpha and Hancock's H coefficients. Results: The original six-factor FPSQ-S structure was retained and demonstrated acceptable overall model fit in this disadvantaged sample (CFI = 0.846, TLI = 0.821, RMSEA = 0.070). Internal consistency ranged from acceptable to excellent across subscales (Cronbach's alpha = 0.63-0.93; Hancock's H = 0.64-0.93). Most items loaded satisfactorily onto their intended constructs; however, two items within the Feeding on Demand construct demonstrated weak factor loadings, and this construct showed lower reliability than the remaining subscales Conclusions: This is the first study to evaluate the FPSQ-S among socioeconomically disadvantaged mothers and fathers of children aged 5-35 months. The FPSQ-S demonstrated acceptable structural validity and reliability. While the six-factor structure was largely supported, further refinement of the Feeding on Demand construct and additional psychometric evaluation are warranted. FAU - Nambiar, Smita AU - Nambiar S AUID- ORCID: 0000-0002-0626-1119 AD - School of Exercise and Nutrition Sciences, Faculty of Health, Queensland University of Technology, Victoria Park Road, Kelvin Grove, QLD 4059, Australia. AD - Centre for Childhood Nutrition Research, Faculty of Health, Queensland University of Technology, 62 Graham Street, South Brisbane, QLD 4101, Australia. FAU - So, Jeffrey T H AU - So JTH AUID- ORCID: 0000-0003-0516-9609 AD - School of Exercise and Nutrition Sciences, Faculty of Health, Queensland University of Technology, Victoria Park Road, Kelvin Grove, QLD 4059, Australia. AD - Centre for Childhood Nutrition Research, Faculty of Health, Queensland University of Technology, 62 Graham Street, South Brisbane, QLD 4101, Australia. AD - School of Health, University of the Sunshine Coast, Sippy Downs, QLD 4556, Australia. FAU - Jansen, Elena AU - Jansen E AUID- ORCID: 0000-0002-6051-4148 AD - Division of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. LA - eng GR - WCCNR03/Children's Hospital Foundation/ PT - Journal Article PT - Validation Study DEP - 20260623 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Female MH - *Feeding Behavior MH - Child, Preschool MH - Cross-Sectional Studies MH - Infant MH - *Mothers MH - *Fathers MH - Surveys and Questionnaires/standards MH - Adult MH - Reproducibility of Results MH - Socioeconomic Factors MH - Factor Analysis, Statistical MH - *Vulnerable Populations MH - Psychometrics MH - Low Socioeconomic Status PMC - PMC13362640 OTO - NOTNLM OT - confirmatory factor analysis OT - fathers OT - feeding practices questionnaire OT - infants and children OT - mothers OT - responsive feeding OT - socioeconomically disadvantage COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 06:37 MHDA- 2026/07/15 12:36 PMCR- 2026/06/23 CRDT- 2026/07/15 01:05 PHST- 2026/05/08 00:00 [received] PHST- 2026/06/12 00:00 [revised] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/07/15 12:36 [medline] PHST- 2026/07/15 06:37 [pubmed] PHST- 2026/07/15 01:05 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - nu18132046 [pii] AID - nutrients-18-02046 [pii] AID - 10.3390/nu18132046 [doi] PST - epublish SO - Nutrients. 2026 Jun 23;18(13):2046. doi: 10.3390/nu18132046. PMID- 42450847 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260715 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 13 DP - 2026 Jun 24 TI - Oral Hygiene Behaviors and Their Association with Angle Malocclusion Classes in Children Aged 6-9 Years: A WHO Questionnaire-Based Study. LID - 10.3390/healthcare14131837 [doi] LID - 1837 AB - BACKGROUND: Childhood oral hygiene behaviors are crucial to preventing oral diseases and can influence the development and progression of malocclusions. The World Health Organization (WHO) Oral Health Questionnaire is a standardized tool for assessing oral hygiene behaviors, oral health-related behaviors, and preventive dental awareness in children. AIM: This study aimed to assess oral hygiene behaviours and examine associations between WHO Oral Health Questionnaire variables and Angle malocclusion classes among children aged 6-9 years. MATERIALS AND METHODS: This cross-sectional study included 90 children aged 6-9 years from the Pristina region, Kosovo. Data were collected using the WHO Oral Health Questionnaire for Children, which assessed oral hygiene habits, toothbrushing frequency, fluoride awareness, dental attendance, dietary behaviors, oral symptoms, and oral-health-related quality of life. Malocclusion was classified according to Angle classification into Class I, II, and III malocclusions with 3D intraoral scanners, Aerolscan 3. Descriptive statistical analysis, Chi-square (chi(2)) test, Spearman correlation analysis, and reliability analysis using Cronbach's Alpha were performed using SPSS Statistics 23.0 (IBM Corp., Armonk, NY, USA) and Statistica 7.1 (StatSoft Inc., Tusla, OK, USA). RESULTS: Most participants reported regular oral hygiene practices, with 46.7% brushing their teeth two or more times daily. However, limited awareness regarding fluoride-containing toothpaste was observed, as most children answered "don't know" regarding fluoride use. Occasional toothache or oral discomfort was reported by 33.3% of participants, while 23.3% reported dissatisfaction with dental appearance. Difficulty biting hard foods was present in 34.4% of children. Reliability analysis of the Q10 section demonstrated moderate internal consistency (Cronbach's Alpha = 0.500). Chi-square analysis demonstrated no statistically significant association between Angle malocclusion classes and WHO questionnaire variables (p > 0.05). The highest chi(2) value was observed for tooth-cleaning frequency (Q7) (chi(2) = 11.97; p = 0.152), although the association remained statistically non-significant. Psychosocial impact questions and oral health-related quality of life questions also demonstrated no statistically significant association with malocclusion classes. CONCLUSIONS: oral hygiene practices, preventative oral health practices, and oral health-related experiences were comparatively similar among children in different Angle malocclusion classes. Although there were no statistically significant correlations found between malocclusion classes and WHO questionnaire variables, the results show that some children have psychosocial concerns about their dental appearance and insufficient awareness of preventive oral health. The WHO Oral Health Questionnaire is a useful epidemiological tool for evaluating pediatric oral health behaviors and may help build youth orthodontic and preventive oral health policies. FAU - Veseli, Kaltrina AU - Veseli K AD - Department of Orthodontics, Alma Mater Europaea, Campus College Rezonanca, 10000 Prishtina, Kosovo. FAU - Haliti, Fehim AU - Haliti F AUID- ORCID: 0009-0004-8977-7402 AD - Department of Pediatric and Preventive Dentistry, Dental School, Faculty of Medicine, University of Prishtina, 10000 Prishtina, Kosovo. FAU - Veseli, Enis AU - Veseli E AD - Department of Prosthodontics, Dental School, Faculty of Medicine, University of Prishtina, 10000 Prishtina, Kosovo. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13361678 OTO - NOTNLM OT - Angle classification OT - WHO Oral Health Questionnaire OT - children OT - malocclusion OT - oral hygiene OT - oral-health-related quality of life OT - pediatric oral health OT - preventive dentistry COIS- The authors declare no conflicts of interest. EDAT- 2026/07/15 06:34 MHDA- 2026/07/15 06:35 PMCR- 2026/06/24 CRDT- 2026/07/15 01:04 PHST- 2026/05/15 00:00 [received] PHST- 2026/06/18 00:00 [revised] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/07/15 06:35 [medline] PHST- 2026/07/15 06:34 [pubmed] PHST- 2026/07/15 01:04 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - healthcare14131837 [pii] AID - healthcare-14-01837 [pii] AID - 10.3390/healthcare14131837 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jun 24;14(13):1837. doi: 10.3390/healthcare14131837. PMID- 42450823 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260715 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 13 DP - 2026 Jun 23 TI - Physical Activity, Physical Fitness, and Motor Competence in Children Aged 5-10 Years-A Systematic Review. LID - 10.3390/healthcare14131813 [doi] LID - 1813 AB - BACKGROUND: Motor competence (MC), physical activity (PA), and physical fitness (PF) are interrelated components of child development, yet evidence on the MC-PF-PA triad in middle childhood remains inconsistent due to methodological heterogeneity. OBJECTIVE: To synthesise associations between MC, PF, and PA in children aged 5-10 years (2020-2025) and to appraise methodological quality and certainty. METHODS: A PRISMA 2020-compliant systematic review (PROSPERO: CRD42024617560) searched six databases (PubMed, Scopus, Web of Science, SportDiscus, SciELO, PsycINFO) from January 2020 to April 2025, updated November 2025. Eligible observational studies in English reported quantitative associations between >/=2 constructs in 5-10-year-olds using validated instruments. Risk of bias was appraised in duplicate with JBI checklists. Quantitative pooling was unfeasible under a pre-specified pooling matrix; associations were synthesised narratively and certainty rated using a GRADE-style framework. RESULTS: Thirteen studies (n = 43-1064; 11 cross-sectional, 2 longitudinal) were included; six were low, five moderate, and two high risk of bias. MC-PA was predominantly positive, especially with objective instruments; MC-PF was consistently positive; PF-PA was less consistent but trended positive longitudinally. Mediation/moderation analyses (k = 3) supported roles for perceived competence, self-efficacy, and PF. Null/negative findings clustered among subjective PA measures and higher risk of bias. GRADE certainty was low-to-moderate. CONCLUSIONS: MC, PF, and PA are interconnected in middle childhood, but cross-sectional predominance and instrument heterogeneity preclude causal inference; findings are provisional and should drive longitudinal, methodologically standardised research. FAU - Rosa, Paulino Gomes AU - Rosa PG AUID- ORCID: 0000-0002-8103-4522 AD - ESECS, Polytechnique University of Leiria, 2411-901 Leiria, Portugal. AD - SPRINT-Sport Physical Activity and Health Research & Innovation Center, 6000-084 Castelo Branco, Portugal. AD - Portugal Life Quality Research Centre (CIEQV), 2040-413 Rio Maior, Portugal. FAU - Furtado, Guilherme Eustaquio AU - Furtado GE AUID- ORCID: 0000-0001-8327-1567 AD - SPRINT-Sport Physical Activity and Health Research & INnovation Center, Polytechnic University of Coimbra, Rua Dom Joao III-Solum, 3030-329 Coimbra, Portugal. AD - Applied Research Institute, Polytechnic Institute of Coimbra, Rua da Misericordia, Lagar dos Corticos-S. Martinho do Bispo, 3045-093 Coimbra, Portugal. FAU - Jacinto, Miguel AU - Jacinto M AUID- ORCID: 0000-0002-1727-3537 AD - ESECS, Polytechnique University of Leiria, 2411-901 Leiria, Portugal. AD - Research Centre in Sports Sciences, Health Sciences and Human Development (CIDESD), 6201-001 Covilha, Portugal. FAU - Ibanez, Sergio Jose AU - Ibanez SJ AUID- ORCID: 0000-0001-6009-4086 AD - Facultad de Ciencias del Deporte, Grupo de Optimizacion del Entrenamiento y Rendimiento Deportivo, Universidad de Extremadura, 10003 Caceres, Spain. FAU - Serrano, Joao AU - Serrano J AUID- ORCID: 0000-0001-5112-4984 AD - SPRINT-Sport Physical Activity and Health Research & Innovation Center, 6000-084 Castelo Branco, Portugal. AD - Department of Sports and Well-Being, Politecnic University of Castelo Branco, 6000-266 Castelo Branco, Portugal. LA - eng PT - Journal Article PT - Review DEP - 20260623 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13361801 OTO - NOTNLM OT - child health promotion OT - fundamental movement skills OT - motor skill development OT - movement behaviours OT - physical literacy OT - school-based interventions COIS- The authors declare that they have no competing interests. EDAT- 2026/07/15 10:10 MHDA- 2026/07/15 10:11 PMCR- 2026/06/23 CRDT- 2026/07/15 01:04 PHST- 2026/02/26 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/07/15 10:11 [medline] PHST- 2026/07/15 10:10 [pubmed] PHST- 2026/07/15 01:04 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - healthcare14131813 [pii] AID - healthcare-14-01813 [pii] AID - 10.3390/healthcare14131813 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jun 23;14(13):1813. doi: 10.3390/healthcare14131813. PMID- 42449312 OWN - NLM STAT- MEDLINE DCOM- 20261010 LR - 20261011 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 14 TI - Diagnostic performance of insulin resistance indices and their association with metabolic outcomes in children with obesity: a 10-year retrospective study from a tertiary pediatric endocrinology center. LID - 10.1186/s12887-026-07183-w [doi] LID - 969 AB - BACKGROUND: Childhood obesity is strongly associated with insulin resistance (IR) and related metabolic complications. However, the optimal surrogate marker for identifying IR in pediatric populations remains unclear. OBJECTIVE: To evaluate the diagnostic performance of commonly used IR indices and to investigate their association with metabolic outcomes in children and adolescents with obesity. METHODS: This retrospective study included 899 children and adolescents with obesity followed at a tertiary pediatric endocrinology center over a 10-year period. IR was defined based on oral glucose tolerance test (OGTT) findings. The diagnostic performance of the fasting glucose-to-insulin ratio (FGIR), quantitative insulin sensitivity check index (QUICKI) and the homeostatic model assessment for insulin resistance (HOMA-IR) was assessed using receiver operating characteristic (ROC) curve analysis. Associations between IR, metabolic syndrome (MS), dysglycemia, hepatic steatosis, and biochemical parameters were analyzed. Multivariate logistic regression was performed to identify independent predictors. RESULTS: HOMA-IR demonstrated the highest diagnostic performance for identifying IR (AUC: 0.711 in girls and 0.700 in boys), outperforming FGIR and QUICKI. Among pubertal participants, the optimal HOMA-IR cut-off values for predicting OGTT-defined insulin resistance were 4.22 in girls and 4.18 in boys. IR was present in 76.3% of participants and was associated with an unfavorable metabolic profile, including higher rates of dysglycemia and hepatic steatosis. Hepatic steatosis was detected in 63.5% of children and was significantly more common in boys. In multivariate analysis, male sex, BMI-SDS, and ALT were independent predictors of hepatic steatosis, whereas IR parameters were not independently associated. TSH levels were higher in IR and MS groups but remained within the normal range. CONCLUSION: HOMA-IR is a reliable and practical marker for identifying IR in children with obesity. While IR is associated with multiple metabolic disturbances, adiposity and liver-related markers appear to play a more dominant role in predicting hepatic steatosis. A comprehensive metabolic evaluation, including both fasting indices and dynamic tests, is essential for early risk stratification in pediatric obesity. CI - (c) 2026. The Author(s). FAU - Eroglu Filibeli, Berna AU - Eroglu Filibeli B AD - Department of Pediatric Endocrinology, Izmir City Hospital, Izmir, Turkey. FAU - Vural Topaktas, Gulumay AU - Vural Topaktas G AD - Department of Pediatric Endocrinology, Izmir City Hospital, Izmir, Turkey. FAU - Yildirim, Julide Gulizar AU - Yildirim JG AD - Faculty of Health Sciences Public Health Nursing Department, Izmir Katip Celebi University, Izmir, Turkey. FAU - Dundar, Bumin AU - Dundar B AD - Department of Pediatric Endocrinology, Izmir Katip Celebi University, Izmir, Turkey. nuri.dundar@ikc.edu.tr. LA - eng PT - Journal Article DEP - 20260714 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 0 (Blood Glucose) RN - 0 (Biomarkers) RN - 0 (Insulin) SB - IM MH - Humans MH - *Insulin Resistance MH - Retrospective Studies MH - Female MH - Male MH - Child MH - Glucose Tolerance Test MH - *Pediatric Obesity/complications/metabolism/blood MH - Adolescent MH - ROC Curve MH - Metabolic Syndrome/diagnosis/etiology MH - Blood Glucose/metabolism/analysis MH - Biomarkers/blood MH - Tertiary Care Centers MH - Insulin/blood MH - Fatty Liver/etiology/diagnosis MH - Logistic Models PMC - PMC13651063 OTO - NOTNLM OT - HOMA-IR OT - Hepatic steatosis OT - Insulin resistance OT - Metabolic syndrome OT - Pediatric obesity COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Tepecik Training and Research Hospital (Approval number: 2022/03 - 02). Written informed consent was obtained from the parents or legal guardians of all participants under 16 years of age in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/15 06:38 MHDA- 2026/10/10 10:05 PMCR- 2026/07/14 CRDT- 2026/07/15 00:08 PHST- 2026/04/16 00:00 [received] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/10/10 10:05 [medline] PHST- 2026/07/15 06:38 [pubmed] PHST- 2026/07/15 00:08 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 10.1186/s12887-026-07183-w [pii] AID - 7183 [pii] AID - 10.1186/s12887-026-07183-w [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 14;26(1):969. doi: 10.1186/s12887-026-07183-w. PMID- 42449271 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261010 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jul 14 TI - Nomogram model for predicting spontaneous preterm birth in twin pregnancies: a case-control study. LID - 10.1186/s12884-026-09663-4 [doi] LID - 1130 AB - BACKGROUND: This study aimed to identify independent factors and develop a nomogram for spontaneous preterm birth in twin pregnancies. METHODS: In this retrospective study, a total of 218 women with twin pregnancies from Jiaxing Women and Children's Hospital, Wenzhou Medical University between June 2021 and May 2024 were enrolled. Univariate analysis and subsequent multivariate logistic regression analysis were used to identify independent factors. A nomogram prediction model was constructed using R software and evaluated by the area under the ROC curve (AUC), concordance index (C-index), and decision curve analysis (DCA). RESULTS: Univariate analysis identified body mass index (BMI) at delivery, cervical length during the second trimester, cervical funnel, gestational vaginitis, gestational diabetes mellitus and prenatal hemoglobin levels as factors associated with spontaneous preterm birth in twin pregnancies (P < 0.05). Multivariable logistic regression analysis confirmed BMI at delivery (OR = 0.887), cervical length during the second trimester (OR = 0.886), and gestational vaginitis (OR = 2.909) as independent predictors. The prediction model demonstrated good performance, with a C-index of 0.838 for the nomogram and an AUC of 0.838 from the ROC curve. DCA indicated the model provided net clinical benefit across a wide range of threshold probabilities. CONCLUSION: A nomogram incorporating BMI at delivery, cervical length during the second trimester, and gestation vaginitis status effectively predicts spontaneous preterm birth in twin pregnancies. This practical tool may aid in individualized risk assessment and guide clinical management. CI - (c) 2026. The Author(s). FAU - Xu, Wei-Na AU - Xu WN AD - Department of Obstetrical, Jiaxing Women and Children's Hospital, Wenzhou Medical University, Jiaxing, 314000, China. FAU - Ai, Ling AU - Ai L AD - Department of Obstetrical, Jiaxing Women and Children's Hospital, Wenzhou Medical University, Jiaxing, 314000, China. FAU - Zhang, Xiao-Yan AU - Zhang XY AD - Department of Central Laboratory, Jiaxing Women and Children's Hospital, Wenzhou Medical University, Jiaxing, 314000, China. FAU - Wang, Jian-Guo AU - Wang JG AD - Department of Central Laboratory, Jiaxing Women and Children's Hospital, Wenzhou Medical University, Jiaxing, 314000, China. FAU - Huang, Yi-Min AU - Huang YM AD - Department of Central Laboratory, Jiaxing Women and Children's Hospital, Wenzhou Medical University, Jiaxing, 314000, China. 15957317870@163.com. LA - eng GR - 2023AY31023/Science and Technology Bureau of Jiaxing City/ GR - 2024KY1694/Zhejiang Provincial Medical and health Science and Technology Program/ PT - Journal Article DEP - 20260714 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Nomograms MH - *Premature Birth/diagnosis/epidemiology/etiology MH - *Pregnancy, Twin MH - Retrospective Studies MH - Adult MH - Case-Control Studies MH - Risk Factors MH - Body Mass Index MH - ROC Curve MH - Cervical Length Measurement MH - Pregnancy Trimester, Second MH - Logistic Models MH - Diabetes, Gestational PMC - PMC13647848 OTO - NOTNLM OT - Delivery outcome OT - Nomogram OT - Risk factor OT - Spontaneous preterm birth OT - Twin pregnancies COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Jiaxing Women and Children's Hospital, Wenzhou Medical University (2024-Y-43). Written informed consent was obtained from all women enrolled in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/15 06:34 MHDA- 2026/10/08 05:31 PMCR- 2026/07/14 CRDT- 2026/07/15 00:07 PHST- 2024/09/03 00:00 [received] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/10/08 05:31 [medline] PHST- 2026/07/15 06:34 [pubmed] PHST- 2026/07/15 00:07 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 10.1186/s12884-026-09663-4 [pii] AID - 9663 [pii] AID - 10.1186/s12884-026-09663-4 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jul 14;26(1):1130. doi: 10.1186/s12884-026-09663-4. PMID- 42449095 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261010 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Jul 14 TI - A cross-sectional study of the associations between intuitive eating and maladaptive eating behaviors in Brazilian University students. LID - 10.1007/s40519-026-01888-8 [doi] LID - 85 AB - PURPOSE: To investigate the relationships between Intuitive Eating and maladaptive eating behaviors among Brazilian university students. METHODS: A cross-sectional quantitative study was conducted among technical, undergraduate, and postgraduate students aged 18 years or above, between 2020 and 2021. Participants completed an online survey comprising sociodemographic questions, the Intuitive Eating Scale-2 (IES-2), and the Three-Factor Eating Questionnaire-Revised 21 (TFEQ-R21), both validated for the Brazilian population. Spearman's correlation and MANCOVA tests were used to assess associations between study variables. RESULTS: The study included 1,237 participants (82.6% females) with a mean age of 26.3 (SD = 8.0) years. Intuitive Eating and its domains were negatively associated with Cognitive Restraint, Emotional Eating and Uncontrolled Eating. In the MANCOVA model, the Unconditional Permission to Eat subscale (IES-2) explained a large proportion of variance in Cognitive Restraint (eta2p = .314), and the Eating for Physical Rather than Emotional Reasons subscale (IES-2) explained a large proportion of variance in Emotional Eating (eta2p = .587). CONCLUSION: Intuitive eating and its domains were negatively associated with maladaptive eating behaviors among Brazilian university students, particularly Emotional Eating and Cognitive Restraint, with Eating for Physical Rather than Emotional Reasons and Unconditional Permission to Eat showing the strongest relationships. LEVEL OF EVIDENCE: Level 4-Cross-sectional study. CI - (c) 2026. The Author(s). FAU - Yavorivski, Andressa AU - Yavorivski A AD - School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil. FAU - Ruiz, Ana Correa AU - Ruiz AC AD - School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil. FAU - Poinhos, Rui AU - Poinhos R AUID- ORCID: 0000-0002-9177-6423 AD - Faculty of Nutrition and Food Sciences, University of Porto, Porto, Portugal. ruipoinhos@fcna.up.pt. AD - Department of Biology and Environment, School of Life and Environmental Sciences, University of Tras-os-Montes e Alto Douro, Vila Real, Portugal. ruipoinhos@fcna.up.pt. FAU - Feoli, Ana Maria Pandolfo AU - Feoli AMP AD - Postgraduate Program in Psychology, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil. LA - eng PT - Journal Article DEP - 20260714 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Brazil MH - Adult MH - Male MH - *Feeding Behavior/psychology MH - Young Adult MH - *Students/psychology MH - Universities MH - Emotional Eating MH - Surveys and Questionnaires MH - *Feeding and Eating Disorders/psychology MH - Adolescent MH - Emotions/physiology MH - *Eating/psychology MH - *Intuition/physiology PMC - PMC13645931 OTO - NOTNLM OT - Disordered eating OT - Eating behavior OT - Emotional eating OT - Intuitive eating OT - Uncontrolled eating COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/15 00:35 MHDA- 2026/10/08 05:31 PMCR- 2026/07/14 CRDT- 2026/07/14 23:35 PHST- 2024/09/11 00:00 [received] PHST- 2026/07/05 00:00 [accepted] PHST- 2026/10/08 05:31 [medline] PHST- 2026/07/15 00:35 [pubmed] PHST- 2026/07/14 23:35 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 10.1007/s40519-026-01888-8 [pii] AID - 1888 [pii] AID - 10.1007/s40519-026-01888-8 [doi] PST - epublish SO - Eat Weight Disord. 2026 Jul 14;31(1):85. doi: 10.1007/s40519-026-01888-8. PMID- 42449006 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2509-8020 (Electronic) IS - 2509-8020 (Linking) VI - 10 IP - 1 DP - 2026 Jul 14 TI - Linguistical and psychometric validation of the MIND Youth Questionnaire (My-Q) in Swedish. LID - 10.1186/s41687-026-01148-4 [doi] LID - 121 AB - BACKGROUND: The Mind Youth Questionnaire is a multidimensional health-related quality-of-life questionnaire designed for pediatric diabetes care and exists in Dutch, English, and Spanish. METHODS: The aim of this study was to linguistically and psychometrically validate the Mind Youth Questionnaire (My-Q) for Swedish-speaking youths with type 1 diabetes. The linguistic process of the Dutch version followed ISPOR s guidelines. For face validity, youths with type 1 diabetes and diabetes nurses were interviewed. Three stigma items were included. The final Swedish My-Q consists of 38 items. A total of 166 youths (10-19 years) completed the My-Q and Pediatric Quality of Life Inventory diabetes module. A 2nd -order confirmatory factor analysis was conducted using the nine-factor Dutch and five-factor Spanish versions. RESULTS: The 2nd -order nine-factor solution (social impact, parents, diabetes control perceptions, responsibilities, worries, treatment satisfaction, body image and eating behavior, stigma, and mood) showed adequate fit: chi2(551) = 828.36 (p < .01), Comparative Fit Index (CFI) = 0.90, Root Mean Square Error of Approximation (RMSEA) = 0.05 [0.05,0.06], Standardized Root Mean Square Residual (SRMR) = 0.08. The nine-factor solution and grouping of the items followed a clear rationale. The reliability coefficients of the total scale were adequate, alpha = 0.86, Omega = 0.90, and Omega for all the factors ranged from 0.49 to 0.88. The relationships between My-Q factors and sociodemographic variables revealed that boys had better health-related quality of life than girls. Younger youths reported better health-related quality of life in terms of body image and eating behavior (p=.005). Concurrent validity was confirmed, as all the factors were positively related to all the Pediatric Quality of Life Inventory diabetes module factors. A negative correlation was found between the level of glycated hemoglobin and the My-Q score (r=-.258, p < .001). CONCLUSION: The Swedish My-Q has adequate psychometric properties and can be used in research and for routine psychosocial assessment. CI - (c) 2026. The Author(s). FAU - Brorsson, Anna Lena AU - Brorsson AL AUID- ORCID: 0000-0002-8136-6340 AD - Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden. anna-lena.brorsson@ki.se. AD - Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. anna-lena.brorsson@ki.se. FAU - Rudilla, David AU - Rudilla D AUID- ORCID: 0000-0002-6042-4724 AD - Pulmonology, Air Liquide Healthcare, Hospital Universitario de la Princesa, Madrid, Spain. FAU - Kleijberg, Max AU - Kleijberg M AD - Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. AD - Department of Health Sciences, Innovation and Design, Malardalen University, Eskilstuna, Sweden. FAU - deWit, Maartje AU - deWit M AD - Medical Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands. FAU - Lundberg, Elena AU - Lundberg E AD - Department of Pediatrics, Institution of Clinical Science, Umea University, Umea, Sweden. FAU - Lindholm-Olinder, Anna AU - Lindholm-Olinder A AUID- ORCID: 0000-0002-8422-2457 AD - Department of Clinical Science and Education, Karolinska Institutet, Stockholm, Sweden. AD - Sachs Children and Youth Hospital, Stockholm South General Hospital, Stockholm, Sweden. LA - eng PT - Journal Article PT - Validation Study DEP - 20260714 PL - Germany TA - J Patient Rep Outcomes JT - Journal of patient-reported outcomes JID - 101722688 SB - IM MH - Humans MH - Male MH - Female MH - *Diabetes Mellitus, Type 1/psychology/therapy MH - Adolescent MH - Psychometrics MH - Child MH - *Quality of Life/psychology MH - Sweden MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Young Adult MH - Linguistics MH - Body Image MH - Factor Analysis, Statistical PMC - PMC13373108 OTO - NOTNLM OT - Questionnaire OT - Type 1 diabetes OT - Validation OT - Youth COIS- Declarations. Ethics approval and consent to participate: The Swedish Ethical Review Authority approved this study (no: 2022-03838-01 and 2022-05738-02), which was conducted in accordance with the Declaration of Helsinki [34]. Consent for publication: Before inclusion, participants and their parents received oral and written information. The participants signed informed consent forms. In accordance with Swedish regulations, the legal guardians of participants under 15 years of age also signed an informed consent form. Competing interests: The authors declare no competing interests. EDAT- 2026/07/15 00:35 MHDA- 2026/07/15 12:37 PMCR- 2026/07/14 CRDT- 2026/07/14 23:32 PHST- 2026/02/04 00:00 [received] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/07/15 12:37 [medline] PHST- 2026/07/15 00:35 [pubmed] PHST- 2026/07/14 23:32 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 10.1186/s41687-026-01148-4 [pii] AID - 1148 [pii] AID - 10.1186/s41687-026-01148-4 [doi] PST - epublish SO - J Patient Rep Outcomes. 2026 Jul 14;10(1):121. doi: 10.1186/s41687-026-01148-4. PMID- 42447709 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260828 IS - 1532-2688 (Electronic) IS - 1059-1311 (Linking) VI - 141 DP - 2026 Sep TI - Predicting the efficacy of classic ketogenic diet therapy in children with refractory epilepsy using dynamic changes in the glucose-ketone index (GKI). PG - 80-85 LID - S1059-1311(26)00189-5 [pii] LID - 10.1016/j.seizure.2026.06.017 [doi] AB - OBJECTIVE: To investigate the predictive value of dynamic changes in blood glucose, blood ketones and glucose-ketone index (GKI) for the efficacy of the classic ketogenic diet (CKD)in children with refractory epilepsy. METHODS: Data from 189 children with refractory epilepsy who received classic ketogenic diet(CKD) between January 2018 and December 2024 were retrospectively analyzed. Blood glucose, blood ketones and the glucose-ketone index (GKI) which defined as the ratio of blood glucose to blood ketone were monitored at multiple time points, from the 2-day period of halving carbohydrate intake to 90 days after CKD initiation. Patients were divided into a responder group (>/=50% seizure reduction) and a non-responder group based on Engel's classification after three months of treatment. Group differences in metabolic indices were assessed, and receiver operating characteristic(ROC) analysis identified optimal GKI thresholds for predicting response. RESULTS: On the first day of CKD therapy, GKI (AUC = 0.638) was the best single predictor of efficacy among all time points, with a cut-off value of 9.63 (sensitivity and specificity both 0.63). Combining blood glucose (<4.95 mmol/L) and blood ketone (>0.75 mmol/L) levels improved predictive performance (AUC = 0.661). CONCLUSION: A GKI > 9.63 on the first day of CKD therapy may serve as an early-warning indicator of poor treatment response. The early treatment phase-from the second day of halving carbohydrate intake to the first day of CKD-represents a critical window for metabolic transition. Monitoring dynamic changes in GKI and blood ketone may facilitate timely adjustment of intervention strategies. CI - Copyright (c) 2026 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. FAU - Li, Jiang AU - Li J AD - Department of Neonatology, Changsha Hospital for Maternal & Child Health Care Affiliated to Hunan Normal University, Changsha, China. FAU - Wang, Tianqi AU - Wang T AD - Department of Neurology, Children's Hospital of Fudan University, Shanghai, China. FAU - Yu, Lifei AU - Yu L AD - Department of Neurology, Children's Hospital of Fudan University, Shanghai, China. Electronic address: yulf_ek@fudan.edu.cn. FAU - Ni, Yan AU - Ni Y AD - Department of Neurology, Children's Hospital of Fudan University, Shanghai, China. FAU - Li, Yijie AU - Li Y AD - Department of Neurology, Children's Hospital of Fudan University, Shanghai, China. FAU - Zhang, Yunjian AU - Zhang Y AD - Department of Neurology, Children's Hospital of Fudan University, Shanghai, China. FAU - Zhou, Shuizhen AU - Zhou S AD - Department of Neurology, Children's Hospital of Fudan University, Shanghai, China. FAU - Wang, Yi AU - Wang Y AD - Department of Neurology, Children's Hospital of Fudan University, Shanghai, China. LA - eng PT - Journal Article DEP - 20260629 PL - England TA - Seizure JT - Seizure JID - 9306979 RN - 0 (Ketones) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - *Diet, Ketogenic/methods MH - *Drug Resistant Epilepsy/diet therapy/blood MH - *Ketones/blood MH - Female MH - *Blood Glucose/metabolism MH - Male MH - Retrospective Studies MH - Child MH - Treatment Outcome MH - Child, Preschool MH - Adolescent OTO - NOTNLM OT - Blood ketone OT - CKD OT - Children with refractory epilepsy OT - Classic ketogenic diet OT - Efficacy prediction OT - GKI COIS- Declaration of competing interest All authors declare no competing interests. EDAT- 2026/07/15 00:34 MHDA- 2026/08/28 23:34 CRDT- 2026/07/14 18:06 PHST- 2026/06/14 00:00 [received] PHST- 2026/06/28 00:00 [accepted] PHST- 2026/08/28 23:34 [medline] PHST- 2026/07/15 00:34 [pubmed] PHST- 2026/07/14 18:06 [entrez] AID - S1059-1311(26)00189-5 [pii] AID - 10.1016/j.seizure.2026.06.017 [doi] PST - ppublish SO - Seizure. 2026 Sep;141:80-85. doi: 10.1016/j.seizure.2026.06.017. Epub 2026 Jun 29. PMID- 42447299 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260807 IS - 1944-0057 (Electronic) IS - 1944-0057 (Linking) VI - 43 IP - 8 DP - 2026 Aug TI - A multi-tiered approach for human health risk assessment of pesticide residues in green peppers using Monte Carlo simulation. PG - 1182-1195 LID - 10.1080/19440049.2026.2691366 [doi] AB - Exposure to pesticide residues in vegetables remains a major concern for human health. This study proposes a robust, multi-tiered human health risk assessment framework to support food safety decision-making, using sweet green peppers as a case study. The approach integrates regulatory compliance assessment (Tier 1), deterministic evaluation (Tier 2), and probabilistic modelling (Tier 3). Pesticide residues from 80 samples were quantified using a QuEChERS UPLC-MS/MS method validated according to SANTE/11312/2021 guidelines. Residues were detected in 37.5% of samples, with 13 active substances quantified above the limit of quantification, and only 3.75% exceeding EU maximum residue limits, indicating high compliance. The deterministic assessment (Tier 2), based on a conservative intake-to-body weight ratio and mean concentrations of quantified residues, resulted in cumulative hazard index (HI) values of 0.044 for adults and 0.046 for children/adolescents. The inclusion of non-quantified compounds using the Middle-Bound approach (LOQ/2) increased the cumulative HI values to 0.067 for adults and 0.071 for children/adolescents. In contrast, the probabilistic risk assessment (Tier 3), based on fitted distributions of residue concentrations and dietary intake, yielded cumulative risk estimates at upper exposure percentiles (p90-p99), ranging from 0.0006 to 0.0045 for adults and from 0.0011 to 0.0057 for children/adolescents. These findings highlight the added value of probabilistic approaches for characterising dietary risk by incorporating exposure variability and reducing uncertainty. In particular, Tier 3 enables a more realistic estimation of exposure based on limited quantitative data and allows the integration and interpretation of values below the LOQ, thereby contributing to a more robust risk assessment. FAU - Boudriiya, Imane AU - Boudriiya I AD - Biotechnology and Biomolecular Engineering Research Team, Faculty of Sciences and Technologies of Tangier, University of Abdelmalek Essaadi, Tangier, Morocco. AD - Regional Laboratory of Analysis and Research, National Office of Food Safety (ONSSA), Tangier, Morocco. FAU - Marti, Vicenc AU - Marti V AD - Chemical Engineering Department, Escola d'Enginyeria de Barcelona Est (EEBE), Universitat Politecnica de Catalunya (UPC)-BarcelonaTECH and Barcelona Research Center for Multiscale Science and Engineering (CCEM), Barcelona, Spain. FAU - Kounnoun, Ayoub AU - Kounnoun A AD - Faculty, of Medical Sciences, UM6P Hospitals, Mohammed VI Polytechnic University, Benguerir, Morocco. FAU - El Maadoudi, Mohammed AU - El Maadoudi M AD - Regional Laboratory of Analysis and Research, National Office of Food Safety (ONSSA), Tangier, Morocco. FAU - Alahlah, Naoual AU - Alahlah N AD - Regional Laboratory of Analysis and Research, National Office of Food Safety (ONSSA), Tangier, Morocco. FAU - Ait Lamine, Naima AU - Ait Lamine N AD - Regional Laboratory of Analysis and Research, National Office of Food Safety (ONSSA), Tangier, Morocco. FAU - Laglaoui, Amin AU - Laglaoui A AD - Biotechnology and Biomolecular Engineering Research Team, Faculty of Sciences and Technologies of Tangier, University of Abdelmalek Essaadi, Tangier, Morocco. FAU - Hassani Zerrouk, Mounir AU - Hassani Zerrouk M AD - Biotechnology and Biomolecular Engineering Research Team, Faculty of Sciences and Technologies of Tangier, University of Abdelmalek Essaadi, Tangier, Morocco. LA - eng PT - Journal Article DEP - 20260714 PL - England TA - Food Addit Contam Part A Chem Anal Control Expo Risk Assess JT - Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment JID - 101485040 RN - 0 (Pesticide Residues) SB - IM MH - Risk Assessment MH - Humans MH - *Pesticide Residues/analysis MH - *Capsicum/chemistry MH - *Food Contamination/analysis MH - *Monte Carlo Method MH - Tandem Mass Spectrometry OTO - NOTNLM OT - QuEChERS OT - UPLC-MS/MS OT - dietary exposure OT - hazard index OT - hazard quotient OT - probabilistic exposure modelling EDAT- 2026/07/14 18:43 MHDA- 2026/08/07 12:39 CRDT- 2026/07/14 15:12 PHST- 2026/08/07 12:39 [medline] PHST- 2026/07/14 18:43 [pubmed] PHST- 2026/07/14 15:12 [entrez] AID - 10.1080/19440049.2026.2691366 [doi] PST - ppublish SO - Food Addit Contam Part A Chem Anal Control Expo Risk Assess. 2026 Aug;43(8):1182-1195. doi: 10.1080/19440049.2026.2691366. Epub 2026 Jul 14. PMID- 42446605 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260926 IS - 1559-0720 (Electronic) IS - 0163-4984 (Linking) VI - 204 IP - 10 DP - 2026 Oct TI - Correlation Between Salivary and Urinary Iodine Indicators in Lactating Women: A Cross-Sectional Study. PG - 8001-8009 LID - 10.1007/s12011-026-05239-7 [doi] AB - Iodine is essential for infant growth and neurodevelopment. To assess iodine nutritional status in populations or individuals a 24-hour urinary iodine concentration (24 h-UIC) is a reliable biomarker but relatively time-consuming and inconvenient method, therefore, more simple alternatives are required. This study examined the correlation between salivary iodine concentration (SIC) and commonly used iodine-related indicators, that is, 24 h-UIC and breast milk iodine concentration (BMIC), and explored the potential of SIC as a biomarker in lactating women. This study recruited 29 healthy lactating women in Luoyang City, Henan Province, China. Over five consecutive days, 24-hour urine samples were collected daily, while saliva and breast milk samples were collected once a day. Inductively coupled plasma mass spectrometry (ICP-MS) was used to determine iodine concentrations in urine, saliva and breast milk. Statistical analyses included Spearman correlation analysis to assess associations between SIC and urinary iodine-related measurements. The median 24 h-UIC was 114.8 microg/L, indicating adequate iodine nutrition in this study population (median UIC < 100 microg/L). SIC showed significant positive correlations with 24 h-UIC and 24-hour urinary iodine excretion (24 h-UIE) (r = 0.689 and 0.460, respectively; P < 0.001), whereas no significant correlation was observed between SIC and BMIC (r = 0.047, P > 0.05). When participants were grouped according to 24 h-UIC (< 100 microg/L vs. >/=100 microg/L), higher SIC levels were observed in the group with higher 24 h-UIC (SIC: 163.4 vs. 109.2 microg/L). The intraindividual variability of SIC was lower than inter-individual variability (18.5 vs. 35.2%), suggesting relatively stable within-subject measurements over repeated sampling. The positive correlation between SIC and 24 h-UIC or 24 h-UIE suggests that SIC may serve as a convenient non-invasive indicator associated with urinary iodine-related measurements in lactating women. However, the observed relationships are exploratory, and further validation in larger and more diverse populations is needed. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Pan, Ziyun AU - Pan Z AD - Key Laboratory of Environmental Nutrition and Population Health, School of Public Health, Department of Nutrition and Food Hygiene, Tianjin Medical University, Tianjin, China. FAU - Li, Xiaorui AU - Li X AD - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Zhao, Teng AU - Zhao T AD - Cangzhou Maternal and Child Health Care Hospital, Cangzhou, Hebei, China. FAU - Wang, Xiru AU - Wang X AD - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Zhang, Ying AU - Zhang Y AD - Key Laboratory of Environmental Nutrition and Population Health, School of Public Health, Department of Nutrition and Food Hygiene, Tianjin Medical University, Tianjin, China. FAU - Wang, Jingyi AU - Wang J AD - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Xie, Haozhuo AU - Xie H AD - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Cai, Yuyang AU - Cai Y AD - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Li, Changjiang AU - Li C AD - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Zhang, Wenhui AU - Zhang W AD - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Zeng, Ziyan AU - Zeng Z AD - Department of Nutrition and Food Hygiene, School of Public Health, Tianjin Medical University, Tianjin, China. FAU - Duan, Lijun AU - Duan L AD - Tianjin First Center Hospital, Tianjin, China. duanlijun79@163.com. FAU - Sang, Zhongna AU - Sang Z AUID- ORCID: 0000-0002-0234-7214 AD - Key Laboratory of Environmental Nutrition and Population Health, School of Public Health, Department of Nutrition and Food Hygiene, Tianjin Medical University, Tianjin, China. sangzhongna@tmu.edu.cn. LA - eng PT - Journal Article DEP - 20260714 PL - United States TA - Biol Trace Elem Res JT - Biological trace element research JID - 7911509 RN - 9679TC07X4 (Iodine) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Iodine/urine/analysis MH - *Lactation/urine/metabolism MH - Adult MH - *Milk, Human/chemistry MH - Cross-Sectional Studies MH - *Saliva/chemistry/metabolism MH - Biomarkers/urine MH - Young Adult OTO - NOTNLM OT - Iodine OT - Lactating women OT - Salivary iodine concentration OT - Urinary iodine concentration COIS- Declarations. Ethics Approval: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Tianjin Medical University(approval number: TMUhMEC2022003). Consent for Publication: Not applicable. Consent to Participate: Written informed consent was obtained from all participants prior to enrollment in the study. Competing Interests: The authors declare no competing interests. EDAT- 2026/07/14 12:35 MHDA- 2026/09/27 02:25 CRDT- 2026/07/14 11:06 PHST- 2026/03/02 00:00 [received] PHST- 2026/07/10 00:00 [accepted] PHST- 2026/09/27 02:25 [medline] PHST- 2026/07/14 12:35 [pubmed] PHST- 2026/07/14 11:06 [entrez] AID - 10.1007/s12011-026-05239-7 [pii] AID - 10.1007/s12011-026-05239-7 [doi] PST - ppublish SO - Biol Trace Elem Res. 2026 Oct;204(10):8001-8009. doi: 10.1007/s12011-026-05239-7. Epub 2026 Jul 14. PMID- 42446071 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261014 IS - 1099-0968 (Electronic) IS - 1072-4133 (Print) IS - 1072-4133 (Linking) VI - 34 IP - 6 DP - 2026 Nov TI - Weight Bias Internalisation and Health-Related Quality of Life in Adolescents: What Role Do Family Meals Play? PG - 1648-1659 LID - 10.1002/erv.70142 [doi] AB - OBJECTIVE: Weight bias internalisation (WBI) has been associated with poorer health-related quality of life (HRQoL), however, evidence in community-based adolescent samples remains scarce. Family meals have shown protective effects on adolescent health, yet their role in the relationship between WBI and HRQoL has not yet been explored. This study investigated associations between WBI, HRQoL, and family meals in Spanish adolescents. METHOD: We conducted a cross-sectional study with a representative sample of 1016 adolescents aged 11-16 from Terrassa, Spain (random multistage cluster sampling). Validated instruments were used to assess WBI (WBIS-M), HRQoL (KIDSCREEN-27), and family dinner quality and frequency. Anthropometric data were objectively measured. Adjusted regression models were conducted. RESULTS: Lower WBI and a higher frequency and quality of family dinners were associated with higher HRQoL scores across KIDSCREEN-27 domains. Further analyses revealed that family dinners moderated the effect of WBI on two HRQoL factors, attenuating its negative impact. However, this moderating impact became substantially weaker at higher levels of WBI. CONCLUSIONS: This study of Spanish adolescents is the first to show a negative association between WBI and HRQoL and that this relationship is moderated by the frequency and quality of shared family meals, suggesting that supportive family environments can buffer WBI's negative impact, although this protective role is attenuated at the highest levels of WBI, highlighting the vital need for early prevention, and warranting further investigation. CI - (c) 2026 Beat Eating Disorders and John Wiley & Sons Ltd. All rights reserved, including rights for text and data mining and training of artificial intelligence technologies or similar technologies. FAU - Broto-Puig, Jaume AU - Broto-Puig J AD - Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. FAU - Latorre-Millan, Miriam AU - Latorre-Millan M AD - Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. AD - Miguel Servet University Hospital, Institute for Health Research Aragon (IIS Aragon), Zaragoza, Spain. AD - Department of Pharmacy and Nutrition, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, Villaviciosa de Odon, Madrid, Spain. FAU - Penelo, Eva AU - Penelo E AD - Departament de Psicobiologia i de Metodologia de les Ciencies de la Salut, Universitat Autonoma de Barcelona, Barcelona, Spain. FAU - Bach-Faig, Anna AU - Bach-Faig A AD - NUTRALiSS Research Group, Faculty of Health Sciences, Open University of Catalonia (UOC), Barcelona, Spain. FAU - Sanchez-Carracedo, David AU - Sanchez-Carracedo D AD - Department of Clinical and Health Psychology, Universitat Autonoma de Barcelona, Barcelona, Spain. LA - eng GR - RTI2018-099293-B-I00/Spanish Ministry of Science and Innovation/ GR - PID2022-138977OB-I00/Spanish Ministry of Science and Innovation/ PT - Journal Article DEP - 20260714 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 SB - IM MH - Humans MH - Adolescent MH - *Quality of Life/psychology MH - Female MH - Cross-Sectional Studies MH - Child MH - Spain MH - Male MH - *Meals/psychology MH - *Body Weight MH - *Family/psychology MH - *Feeding Behavior/psychology MH - *Body Image/psychology PMC - PMC13656762 OTO - NOTNLM OT - family dinner index OT - family meals OT - quality of life OT - weight bias internalisation OT - weight stigma COIS- The authors declare no conflicts of interest. EDAT- 2026/07/14 14:00 MHDA- 2026/10/12 11:41 PMCR- 2026/10/12 CRDT- 2026/07/14 08:03 PHST- 2026/06/09 00:00 [revised] PHST- 2026/03/09 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/10/12 11:41 [medline] PHST- 2026/07/14 14:00 [pubmed] PHST- 2026/07/14 08:03 [entrez] PHST- 2026/10/12 00:00 [pmc-release] AID - ERV70142 [pii] AID - 10.1002/erv.70142 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2026 Nov;34(6):1648-1659. doi: 10.1002/erv.70142. Epub 2026 Jul 14. PMID- 42445937 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260714 LR - 20260813 IS - 2055-7647 (Print) IS - 2055-7647 (Electronic) IS - 2055-7647 (Linking) VI - 12 IP - 3 DP - 2026 TI - Associations of academic performance, sports participation, disordered eating and menstrual cycle irregularities in adolescents: a population-based study. PG - e003078 LID - 10.1136/bmjsem-2025-003078 [doi] LID - e003078 AB - BACKGROUND: Regular menstruation is an important indicator of well-being in adolescent females. We aimed to assess risk factors associated with menstrual cycle irregularities in a population-based cohort of high school students. METHODS: In the fall of 2022, we recruited a cohort of 1161 first-year female students from 21 socio-economically diverse high schools in the capital region of Finland. Participants completed an online survey addressing menstruation, academic performance and sports participation and validated questionnaires (the Sick-Control-One stone-Fat-Food (SCOFF) eating disorder screening tool and School Burnout Inventory). RESULTS: Of 935 (81%) participants (mean age 16) not using hormonal preparations, 336 (37%) reported irregular menstruation. Elevated School Burnout Inventory scores (per point OR 1.03, 95% CI 1.01 to 1.05), lower body mass index (OR 1.86, 95% CI 1.12 to 3.08) and high SCOFF scores (OR 2.09, 95% CI 1.40 to 3.10) were associated with irregular menstruation. Overall physical activity levels showed no significant association with menstruation. In subgroup analysis, low body mass index and disordered eating symptoms were associated with irregular menstruation among casual exercisers whereas school burnout was associated with irregular menstruation among competitive athletes. CONCLUSION: School-related stress, eating and exercise habits should be evaluated among high school students presenting with menstrual irregularities, as these factors may be relevant in identifying adolescents at risk of more severe reproductive dysfunctions, including amenorrhoea. CI - Copyright (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Moro, Sara Maria Margareeta AU - Moro SMM AUID- ORCID: 0009-0007-7340-5817 AD - Helsinki University Hospital, New Children's Hospital, Helsinki, Finland. AD - Clinicum, University of Helsinki, Helsinki, Finland. FAU - Holopainen, Elina AU - Holopainen E AD - Clinicum, University of Helsinki, Helsinki, Finland. AD - Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland. FAU - Saari, Viivi AU - Saari V AD - Clinicum, University of Helsinki, Helsinki, Finland. AD - Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland. FAU - Kosola, Silja AU - Kosola S AD - Clinicum, University of Helsinki, Helsinki, Finland. AD - Research Services, Western Uusimaa County Wellbeing Services, Espoo, Finland. LA - eng PT - Journal Article DEP - 20260710 PL - England TA - BMJ Open Sport Exerc Med JT - BMJ open sport & exercise medicine JID - 101681007 PMC - PMC13358262 OTO - NOTNLM OT - Adolescent OT - Eating disorders OT - Menstruation OT - Physical activity COIS- None declared. EDAT- 2026/07/14 18:26 MHDA- 2026/07/14 18:27 PMCR- 2026/07/10 CRDT- 2026/07/14 06:56 PHST- 2025/11/05 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/07/14 18:27 [medline] PHST- 2026/07/14 18:26 [pubmed] PHST- 2026/07/14 06:56 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - bmjsem-2025-003078 [pii] AID - 10.1136/bmjsem-2025-003078 [doi] PST - epublish SO - BMJ Open Sport Exerc Med. 2026 Jul 10;12(3):e003078. doi: 10.1136/bmjsem-2025-003078. eCollection 2026. PMID- 42445753 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1658-3175 (Electronic) IS - 0379-5284 (Print) IS - 0379-5284 (Linking) VI - 47 IP - 8 DP - 2026 Aug TI - Dietary Fat Intake and Its Influence on the Association Between Liver Fat and Brain Choline Metabolism in Young Saudi Women. PG - 1309-1315 LID - 10.15537/1658-3175.8822 [doi] AB - OBJECTIVE: Fat-rich nutrition may influence the neurochemical consequences of hepatic lipid accumulation. This study examined whether percent energy from fat modifies the association between liver fat and the brain (Cho/Cr) ratio in healthy young women. METHODS: A total of 109 healthy Saudi women aged 18-25 years underwent brain magnetic resonance spectroscopy ((1)H-MRS) to quantify Cho/Cr ratios. Liver fat was estimated using MRI-based proton density fat fraction (PDFF), and lipid intake was assessed using a validated food frequency questionnaire. Multivariable regression models tested the interaction between liver fat and fat-derived energy intake, followed by simple slopes analysis, regression diagnostics, and false discovery rate (FDR) correction. RESULTS: A modest but statistically significant interaction was observed between liver fat and reported fat intake in relation to the brain Cho/Cr ratio (p = 0.037). The association between liver fat and Cho/Cr appeared stronger at higher levels of fat consumption (+1 SD) and weaker at lower intake (-1 SD). Regression diagnostics indicated no multicollinearity or heteroscedasticity, and FDR correction supported the stability of the interaction. CONCLUSION: Fat intake may modify the relationship between liver fat and brain choline metabolism in young women. These findings suggest that nutritional context could play a role in liver-brain metabolic coupling, although the effect size is modest and should be interpreted with caution. CI - Copyright: (c) Saudi Medical Journal. FAU - Hawesa, Halima S AU - Hawesa HS AUID- ORCID: 0000-0002-8478-971X AD - Department of Radiological Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Box 84428, Riyadh 11671, Saudi Arabia. FAU - Shanawani, Mansour E AU - Shanawani ME AD - Department of Radiology, King Abdullah bin Abdulaziz University Hospital, Riyadh, Kingdom of Saudi Arabia. FAU - Alshegri, Haya A AU - Alshegri HA AD - Department of Radiology, King Abdullah bin Abdulaziz University Hospital, Riyadh, Kingdom of Saudi Arabia. FAU - Hassan, Mahasin G AU - Hassan MG AD - College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia. FAU - Alorainy, Amal I AU - Alorainy AI AD - College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia. FAU - Alroqaiba, Nouf A AU - Alroqaiba NA AD - College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia. FAU - Sheikh, Shanoo G A AU - Sheikh SGA AD - College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Kingdom of Saudi Arabia. LA - eng PT - Journal Article DEP - 20260707 PL - Saudi Arabia TA - Saudi Med J JT - Saudi medical journal JID - 7909441 RN - N91BDP6H0X (Choline) RN - 0 (Dietary Fats) SB - IM MH - Humans MH - Female MH - *Choline/metabolism MH - *Brain/metabolism MH - *Liver/metabolism MH - Young Adult MH - Adult MH - Saudi Arabia MH - Adolescent MH - *Dietary Fats/administration & dosage MH - Magnetic Resonance Spectroscopy PMC - PMC13360573 OTO - NOTNLM OT - Brain/metabolism OT - Choline/metabolism OT - Dietary fats OT - Fatty liver OT - Female OT - Magnetic resonance spectroscopy OT - Saudi Arabia OT - Young adult EDAT- 2026/07/14 18:26 MHDA- 2026/07/14 18:27 PMCR- 2026/08/01 CRDT- 2026/07/14 06:54 PHST- 2025/11/24 00:00 [received] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/07/14 18:27 [medline] PHST- 2026/07/14 18:26 [pubmed] PHST- 2026/07/14 06:54 [entrez] PHST- 2026/08/01 00:00 [pmc-release] AID - saudimedj-47-8-1309 [pii] AID - 10.15537/1658-3175.8822 [doi] PST - ppublish SO - Saudi Med J. 2026 Aug;47(8):1309-1315. doi: 10.15537/1658-3175.8822. Epub 2026 Jul 7. PMID- 42444614 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1099-1492 (Electronic) IS - 0952-3480 (Print) IS - 0952-3480 (Linking) VI - 39 IP - 8 DP - 2026 Aug TI - Serum and Urine Metabolomic Profiles in Children With Growth Retardation: An Exploratory (1)H-NMR Study. PG - e70356 LID - 10.1002/nbm.70356 [doi] LID - e70356 AB - Growth retardation, defined by impaired anthropometric development relative to age-based population standards, may be accompanied by metabolic alterations. This study aimed to characterize serum and urine metabolomic profiles in children with growth retardation using exploratory (1)H-NMR spectroscopy. Thirty children with growth retardation and 24 controls were included in this cross-sectional study. Serum and urine samples were analyzed by (1)H-NMR spectroscopy, and annotated metabolites were evaluated using Chenomx, MetaboAnalyst, and R software. Clinical and laboratory variables were compared between groups. Metabolomic analysis included univariate comparisons, volcano plots, PCA, OPLS-DA, Spearman correlation analysis, age-adjusted regression, exploratory ROC analysis, and metabolite set enrichment analysis. The growth retardation group had lower age and BMI than controls, while serum iron and AST were higher. Volcano plot analysis showed a more distinct pattern of nominal metabolite alterations in serum than in urine. In serum, 3-hydroxybutyrate and glucuronate showed relative increases, whereas N-acetylgalactosamine, alanine, glutamate, and glucose showed relative decreases. In urine, metabolite differences were less pronounced. Multivariate analysis demonstrated a significant overall group effect in serum but not in urine. Within the growth retardation group, age was negatively correlated with serum 3-hydroxybutyrate and positively correlated with N-acetyl-L-aspartic acid, whereas several urinary metabolites showed negative correlations with age. After age adjustment, only 4-ethylbenzoic acid remained significant in serum after multiple testing correction. Exploratory ROC analysis identified N-acetylgalactosamine and 4-ethylbenzoic acid in serum and beta-alanine and creatinine in urine as the metabolites with the highest within cohort classification tendency. Children with growth retardation exhibited modest metabolic differences, with more consistent group-related alterations observed in serum than in urine. These findings mainly suggest changes related to energy metabolism, amino acid turnover, and intermediary metabolism. However, the results remain exploratory and require confirmation in larger, age-stratified and independently validated cohorts. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Alim, Mehtap AU - Alim M AUID- ORCID: 0000-0003-0818-7714 AD - Health Sciences Institute, Bezmialem Vakif University, Istanbul, Turkiye. AD - Department of Medical Biochemistry, Bezmialem Vakif University Faculty of Medicine, Istanbul, Turkiye. FAU - Demirel, Metin AU - Demirel M AUID- ORCID: 0000-0003-4810-6771 AD - Department of Medical Biochemistry, Bezmialem Vakif University Faculty of Medicine, Istanbul, Turkiye. FAU - Koktasoglu, Fatmanur AU - Koktasoglu F AUID- ORCID: 0000-0002-3201-5923 AD - Department of Medical Biochemistry, Bezmialem Vakif University Faculty of Medicine, Istanbul, Turkiye. FAU - Ozgurhan, Gamze AU - Ozgurhan G AUID- ORCID: 0000-0002-8063-1931 AD - Clinic of Pediatrics, Istanbul Education Research Hospital, Istanbul, Turkiye. FAU - Pasin, Ozge AU - Pasin O AUID- ORCID: 0000-0001-6530-0942 AD - Department of Biostatistics, Hamidiye Medical Faculty, Health Sciences University, Istanbul, Turkiye. FAU - Bas, Suleyman AU - Bas S AUID- ORCID: 0000-0002-5883-445X AD - University of Health Sciences, Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, Istanbul, Turkiye. FAU - Selek, Sahabettin AU - Selek S AUID- ORCID: 0000-0003-1235-3957 AD - Department of Medical Biochemistry, Bezmialem Vakif University Faculty of Medicine, Istanbul, Turkiye. LA - eng GR - 20240602/Bezmialem Vakif Universitesi/ PT - Journal Article PL - England TA - NMR Biomed JT - NMR in biomedicine JID - 8915233 SB - IM MH - Humans MH - Male MH - Female MH - *Metabolomics MH - *Metabolome MH - Child MH - *Proton Magnetic Resonance Spectroscopy MH - *Growth Disorders/urine/blood/metabolism MH - Child, Preschool MH - Multivariate Analysis PMC - PMC13366460 OTO - NOTNLM OT - acetylgalactosamine OT - magnetic resonance spectroscopy OT - metabolic networks and pathways OT - metabolic profiling OT - pediatric growth disorders COIS- The authors declare no conflicts of interest. EDAT- 2026/07/14 14:02 MHDA- 2026/07/14 14:03 PMCR- 2026/07/14 CRDT- 2026/07/14 06:23 PHST- 2026/06/18 00:00 [revised] PHST- 2026/04/04 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/07/14 14:03 [medline] PHST- 2026/07/14 14:02 [pubmed] PHST- 2026/07/14 06:23 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - NBM70356 [pii] AID - 10.1002/nbm.70356 [doi] PST - ppublish SO - NMR Biomed. 2026 Aug;39(8):e70356. doi: 10.1002/nbm.70356. PMID- 42443053 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 2047-6310 (Electronic) IS - 2047-6302 (Print) IS - 2047-6302 (Linking) VI - 21 IP - 7 DP - 2026 Jul TI - Differences in Fat Depots, Cardiometabolic Risk Factors, and Insulin Resistance Between Active and Passive School Commuters. PG - e70134 LID - 10.1111/ijpo.70134 [doi] LID - e70134 AB - BACKGROUND: Active commuting to and from school (ACS) is a feasible strategy to increase daily physical activity in children. Although ACS has been associated with favourable body composition and selected cardiometabolic markers, its association with specific ectopic fat depots remains unclear in paediatric populations. OBJECTIVE: To examine differences in specific fat depots and cardiometabolic risk factors between children who actively and passively commute to school. METHODS: Cross-sectional baseline data from 174 children (48.9% girls; mean age 10.8 +/- 1.4 years) participating in the EFIGRO and MICROKID projects were analysed. ACS mode was self-reported using a validated questionnaire and classified as active or passive. Visceral adipose tissue, abdominal subcutaneous adipose tissue, intermuscular abdominal adipose tissue, hepatic fat, intrapancreatic fat, and lumbar spine marrow fat were assessed using magnetic resonance imaging. Cardiometabolic risk factors included blood pressure, triglycerides, high-density lipoprotein cholesterol, glucose, insulin, and insulin resistance estimated by the homeostasis model assessment. RESULTS: No significant differences were observed between active and passive commuters for any fat depot (all p >/= 0.150) or cardiometabolic risk factors, including insulin resistance and the overall cardiometabolic risk score (all p >/= 0.220). CONCLUSIONS: Active commuting to/from school was not associated with differences in ectopic fat depots, cardiometabolic risk factors, or insulin resistance in children. CI - (c) 2026 The Author(s). Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation. FAU - Rodriguez-Sanchez, David AU - Rodriguez-Sanchez D AUID- ORCID: 0009-0006-5498-2240 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. FAU - Huertas-Delgado, Francisco Javier AU - Huertas-Delgado FJ AD - "La Inmaculada" Teacher Training Centre, University of Granada, Granada, Spain. FAU - Medrano, Maria AU - Medrano M AD - Department of Health Sciences, Institute for Sustainability & Food Chain Innovation (IS-FOOD), Public University of Navarra, Pamplona, Spain. AD - IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. AD - CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain. FAU - Idoate, Fernando AU - Idoate F AD - Radiology Department, Mutua Navarra, Department of Health Sciences, Public University of Navarra, Pamplona, Spain. FAU - Cabeza, Rafael AU - Cabeza R AD - Department of Electrical, Electronic and Communications Engineering, Public University of Navarra, Pamplona, Spain. FAU - Cadenas-Sanchez, Cristina AU - Cadenas-Sanchez C AUID- ORCID: 0000-0002-4513-9108 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. AD - CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain. FAU - Labayen, Idoia AU - Labayen I AD - Department of Health Sciences, Institute for Sustainability & Food Chain Innovation (IS-FOOD), Public University of Navarra, Pamplona, Spain. AD - IdiSNA, Navarra Institute for Health Research, Pamplona, Spain. AD - CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain. LA - eng GR - DEP2016-78377-R/Spanish Ministry of Industry and Competitiveness/ GR - PI13/01335/Spanish Ministry of Health "Fondos de Investigacion Sanitaria del Instituto de Salud Carlos III"/ GR - 0011-1365-2019-000085/Department of Economic Development of the Government of Navarra/ GR - European Union Structural Funds (European Regional Development Fund, FEDER, "Una manera de hacer Europa")/ GR - FPU23/02198/Spanish Ministry of Universities/ GR - European Union's Horizon 2020/ GR - 101028929/Marie Sklodowska-Curie/ GR - NNF23SA0083955/European Association for the Study of Obesity-Novo Nordisk Foundation/ GR - CB22/03/00058/CIBEROBN/ GR - Instituto de Salud Carlos III, Ministerio de Ciencia e Innovacion, and the European Union/ GR - Universidad de Granada/CBUA/ PT - Journal Article PL - England TA - Pediatr Obes JT - Pediatric obesity JID - 101572033 SB - IM MH - Humans MH - Female MH - *Insulin Resistance MH - Child MH - Cross-Sectional Studies MH - Cardiometabolic Risk Factors MH - Male MH - *Transportation MH - Schools MH - Magnetic Resonance Imaging MH - *Exercise MH - Risk Factors MH - *Cardiovascular Diseases/prevention & control MH - Body Composition MH - Adiposity MH - *Adipose Tissue PMC - PMC13364722 OTO - NOTNLM OT - active transport OT - cardiometabolic health OT - ectopic adiposity OT - metabolic syndrome COIS- The authors declare no conflicts of interest. EDAT- 2026/07/14 00:35 MHDA- 2026/07/14 12:35 PMCR- 2026/07/14 CRDT- 2026/07/13 22:02 PHST- 2026/06/19 00:00 [revised] PHST- 2026/01/22 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/07/14 12:35 [medline] PHST- 2026/07/14 00:35 [pubmed] PHST- 2026/07/13 22:02 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - IJPO70134 [pii] AID - 10.1111/ijpo.70134 [doi] PST - ppublish SO - Pediatr Obes. 2026 Jul;21(7):e70134. doi: 10.1111/ijpo.70134. PMID- 42442643 OWN - NLM STAT- MEDLINE DCOM- 20260810 LR - 20260810 IS - 1872-7573 (Electronic) IS - 0378-8741 (Linking) VI - 372 DP - 2027 Jan 10 TI - Assessment of Xiao'er Xiexieting Keli-induced toxicity in juvenile rats. PG - 122185 LID - S0378-8741(26)01039-1 [pii] LID - 10.1016/j.jep.2026.122185 [doi] AB - ETHNOPHARMACOLOGICAL RELEVANCE: Sufficient safety data on juvenile development is not available for Xiao'er Xiexieting Keli (XXTK), a Chinese herbal formula for pediatric diarrhea. AIM OF THE STUDY: Considering the challenges associated with clinical trials of XXTK, this study was aimed at evaluating its toxicity in juvenile rats to obtain a basis for assessing its safety and dosage in children. MATERIALS AND METHODS: In acute toxicity study (Study 1), postnatal day (PND) 24 rats were orally administered 253.13 g/kg XXTK and observed over 14 days. In subacute toxicity study (Study 2), PND21 rats were administered 1.74, 8.71, or 32.66 g/kg XXTK daily for six consecutive weeks and allowed to recover for 4 weeks. Clinical signs, body weight, food intake, and timing of vaginal opening and preputial separation were recorded during the dosing period. Hematological, serum biochemical, and histopathological examinations, Irwin's test, and assessment of growth hormone levels, skeletal development, and immune-related indicators were performed mid-administration, and at culmination of dosing and recovery. Urinalysis, ophthalmological assessment, and Morris water maze test were conducted at the end of dosing and recovery periods. RESULTS: No deaths or significant findings occurred in Study 1; maximum tolerated dose was 253.13 g/kg. In Study 2, all changes were reversible, mild, and without toxicological significance. The no-observed-adverse-effect level was 32.66 g/kg/day. CONCLUSION: XXTK demonstrated a favorable toxicological safety profile in juvenile rats, supporting its potential for extended clinical use in children. Further evaluation of child development-related indicators and validation in pediatric clinical cohorts are recommended. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Liu, Junxiu AU - Liu J AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. FAU - Zhu, Lin AU - Zhu L AD - Hangzhou Huqingyutang Pharmaceutical Co., Ltd, China. FAU - Lu, Xiaojing AU - Lu X AD - Hangzhou Huqingyutang Pharmaceutical Co., Ltd, China. FAU - Fu, Weidong AU - Fu W AD - Hangzhou Huqingyutang Pharmaceutical Co., Ltd, China. FAU - Rao, Tingfei AU - Rao T AD - Hangzhou Huqingyutang Pharmaceutical Co., Ltd, China. FAU - Zhang, Lili AU - Zhang L AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. FAU - Wang, Jiahong AU - Wang J AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. FAU - Chen, Lingfang AU - Chen L AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. FAU - Tian, Ruiyu AU - Tian R AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. FAU - Zhu, Haojie AU - Zhu H AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. FAU - Ge, Lingyun AU - Ge L AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. FAU - Wu, Lei AU - Wu L AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. FAU - Lv, Wanqiang AU - Lv W AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. FAU - Huang, Wenhai AU - Huang W AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. Electronic address: hwh@hmc.edu.cn. FAU - Huang, Linfeng AU - Huang L AD - Hangzhou Huqingyutang Pharmaceutical Co., Ltd, China. Electronic address: hlf8165771@126.com. FAU - Song, Yisheng AU - Song Y AD - Key Laboratory of Drug Safety Evaluation and Research of Zhejiang Province, Center of Safety Evaluation and Research, Hangzhou Medical College, Hangzhou, 310053, China. Electronic address: alicesys_song@163.com. LA - eng PT - Journal Article DEP - 20260713 PL - Ireland TA - J Ethnopharmacol JT - Journal of ethnopharmacology JID - 7903310 RN - 0 (Drugs, Chinese Herbal) SB - IM MH - Animals MH - *Drugs, Chinese Herbal/toxicity/administration & dosage MH - Female MH - Male MH - Rats MH - No-Observed-Adverse-Effect Level MH - Toxicity Tests, Acute MH - Rats, Sprague-Dawley MH - Dose-Response Relationship, Drug MH - Body Weight/drug effects OTO - NOTNLM OT - Acute toxicity OT - Juvenile OT - No-observed adverse effect level OT - Safety evaluation OT - Subacute toxicity OT - Xiao'er Xiexieting Keli COIS- Declaration of competing interest I have nothing to declare. EDAT- 2026/07/14 00:34 MHDA- 2026/08/11 00:35 CRDT- 2026/07/13 19:13 PHST- 2026/05/26 00:00 [received] PHST- 2026/07/03 00:00 [revised] PHST- 2026/07/12 00:00 [accepted] PHST- 2026/08/11 00:35 [medline] PHST- 2026/07/14 00:34 [pubmed] PHST- 2026/07/13 19:13 [entrez] AID - S0378-8741(26)01039-1 [pii] AID - 10.1016/j.jep.2026.122185 [doi] PST - ppublish SO - J Ethnopharmacol. 2027 Jan 10;372:122185. doi: 10.1016/j.jep.2026.122185. Epub 2026 Jul 13. PMID- 42442595 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260731 IS - 1096-0295 (Electronic) IS - 0273-2300 (Linking) VI - 171 DP - 2026 Nov TI - Bisphenol A concentrations in isot spice and associated health risk assessment using Monte Carlo simulation in Turkiye. PG - 106179 LID - S0273-2300(26)00152-2 [pii] LID - 10.1016/j.yrtph.2026.106179 [doi] AB - Bisphenol A (BPA) is a well-known endocrine-disrupting chemical, yet its potential migration into traditional spice matrices during processing remains a critical and overlooked food safety concern. To address this knowledge gap, this study presents the first comprehensive investigation of BPA concentrations in isot spice and assesses the associated dietary health risks. A total of 46 samples (23 homemade and 23 industrial) from Sanliurfa, Turkey, were analyzed using a validated ELISA kit, along with pH and CIELAB color parameters. Estimated Daily Intake (EDI) and Target Hazard Quotient (THQ) were calculated for adult and pediatric populations using Monte Carlo simulations. BPA concentrations ranged from 0.40 to 361.30 mug/kg (mean: 73.88 +/- 19.15 mug/kg) in homemade samples and from 0.49 to 285.39 mug/kg (mean: 67.15 +/- 14.87 mug/kg) in industrial samples, with no significant differences between groups (p > 0.05). While dietary risks were within safe limits according to US EPA doses, assessment based on stricter European Food Safety Authority (EFSA) thresholds revealed that THQ values significantly exceeded 1, particularly for children, indicating potential chronic health risks. These findings highlight the prevalence of BPA in traditional spices and underscore the need for improved production and packaging practices to reduce consumer exposure. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Oncu, Cemile AU - Oncu C AD - Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Harran University, Sanliurfa, Turkiye. FAU - Aydemir, Mehmet Emin AU - Aydemir ME AD - Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Harran University, Sanliurfa, Turkiye. Electronic address: aydemiremin23@harran.edu.tr. FAU - Giraz, Mehmet Nuri AU - Giraz MN AD - Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Harran University, Sanliurfa, Turkiye. FAU - Tugbay, Emine Betul AU - Tugbay EB AD - Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Harran University, Sanliurfa, Turkiye. FAU - Altun, Serap Kilic AU - Altun SK AD - Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Harran University, Sanliurfa, Turkiye. FAU - Yalcin, Hamza AU - Yalcin H AD - Department of Animal Science, Faculty of Agriculture, Harran University, Sanliurfa, Turkiye. LA - eng PT - Journal Article DEP - 20260713 PL - Netherlands TA - Regul Toxicol Pharmacol JT - Regulatory toxicology and pharmacology : RTP JID - 8214983 RN - 0 (Bisphenol A Compounds) RN - 0 (Phenols) RN - MLT3645I99 (bisphenol A) RN - 0 (Benzhydryl Compounds) RN - 0 (Endocrine Disruptors) SB - IM MH - Bisphenol A Compounds MH - *Phenols/analysis MH - Monte Carlo Method MH - Risk Assessment MH - *Benzhydryl Compounds/analysis MH - Humans MH - *Food Contamination/analysis MH - *Spices/analysis MH - Turkey MH - *Endocrine Disruptors/analysis OTO - NOTNLM OT - Bisphenol A OT - ELISA OT - Isot spice OT - Monte Carlo simulation OT - Risk assessment COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/14 04:10 MHDA- 2026/08/01 00:36 CRDT- 2026/07/13 19:12 PHST- 2025/10/15 00:00 [received] PHST- 2026/06/16 00:00 [revised] PHST- 2026/07/13 00:00 [accepted] PHST- 2026/08/01 00:36 [medline] PHST- 2026/07/14 04:10 [pubmed] PHST- 2026/07/13 19:12 [entrez] AID - S0273-2300(26)00152-2 [pii] AID - 10.1016/j.yrtph.2026.106179 [doi] PST - ppublish SO - Regul Toxicol Pharmacol. 2026 Nov;171:106179. doi: 10.1016/j.yrtph.2026.106179. Epub 2026 Jul 13. PMID- 42442333 OWN - NLM STAT- MEDLINE DCOM- 20260824 LR - 20260824 IS - 1873-5150 (Electronic) IS - 0887-8994 (Linking) VI - 182 DP - 2026 Sep TI - The Association Between Polyphenols Intake of Pregnant Mothers and Neurodevelopment Indices in Their Children: The Prospective Epidemiological Research Studies in Iran Birth Cohort-Isfahan. PG - 73-80 LID - S0887-8994(26)00188-8 [pii] LID - 10.1016/j.pediatrneurol.2026.06.015 [doi] AB - BACKGROUND: Polyphenol intake is important for neurological health; however, limited evidence has examined the association between maternal dietary polyphenol intake during pregnancy and children's neurodevelopment. This study aimed to investigate the relationship between maternal polyphenol consumption across pregnancy trimesters and neurodevelopmental outcomes in children. METHODS: This prospective cohort study included 945 mother-child pairs from the Isfahan Birth Cohort. Maternal dietary intake was assessed using a validated 90-item food frequency questionnaire. Polyphenol intake was estimated using the Phenol-Explorer database. Children's neurodevelopment and behavioral outcomes were evaluated using the Ages and Stages Questionnaire and the Child Behavior Checklist. RESULTS: Higher maternal polyphenol intake during the first trimester was associated with lower odds of adverse behavioral outcomes at 2 years of age. In adjusted models, the second (odds ratio [OR]: 0.370, 95% confidence interval [CI]: 0.197-0.693) and third tertiles (OR: 0.523, 95% CI: 0.297-0.920) of polyphenol intake were associated with reduced odds compared to the lowest tertile. Similar associations were observed for the second tertile of polyphenol intake during the first trimester (OR: 0.317, 95% CI: 0.123-0.816) and third trimester (OR: 0.380, 95% CI: 0.152-0.954). No consistent associations were observed at later follow-up ages. CONCLUSIONS: Higher maternal polyphenol intake during pregnancy, particularly in early gestation, may be associated with more favorable early neurodevelopmental and behavioral outcomes. However, these associations were not consistent across all ages, and causality cannot be inferred. Further studies using objective measures of polyphenol exposure and long-term follow-up are warranted. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Amini-Kahrizsangi, Masoud AU - Amini-Kahrizsangi M AD - Nutrition and Food Security Research Center, Department of Community Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Nouri, Fatemeh AU - Nouri F AD - Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Heidari-Beni, Motahar AU - Heidari-Beni M AD - Child Growth and Development Research Center, Department of Nutrition, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: heidari.motahar@gmail.com. FAU - Rouhani, Mohammad Hossein AU - Rouhani MH AD - Nutrition and Food Security Research Center, Department of Community Nutrition, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Kelishadi, Roya AU - Kelishadi R AD - Child Growth and Development Research Center, Department of Nutrition, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran. LA - eng PT - Journal Article DEP - 20260625 PL - United States TA - Pediatr Neurol JT - Pediatric neurology JID - 8508183 RN - 0 (Polyphenols) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Polyphenols/administration & dosage MH - Iran/epidemiology MH - *Prenatal Exposure Delayed Effects/epidemiology MH - Neurodevelopment MH - Prospective Studies MH - Child, Preschool MH - *Child Development/physiology MH - Adult MH - Birth Cohort MH - Developmental Origins of Health and Disease OTO - NOTNLM OT - Children OT - Neurodevelopment OT - Polyphenols OT - Pregnancy COIS- Fundings This study was conducted as the project number 3403325 supported by Isfahan University of Medical Sciences. EDAT- 2026/07/14 04:10 MHDA- 2026/08/24 23:34 CRDT- 2026/07/13 18:10 PHST- 2025/08/31 00:00 [received] PHST- 2026/05/18 00:00 [revised] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/08/24 23:34 [medline] PHST- 2026/07/14 04:10 [pubmed] PHST- 2026/07/13 18:10 [entrez] AID - S0887-8994(26)00188-8 [pii] AID - 10.1016/j.pediatrneurol.2026.06.015 [doi] PST - ppublish SO - Pediatr Neurol. 2026 Sep;182:73-80. doi: 10.1016/j.pediatrneurol.2026.06.015. Epub 2026 Jun 25. PMID- 42442126 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260807 IS - 1724-191X (Electronic) IS - 1120-1797 (Linking) VI - 148 DP - 2026 Aug TI - Integration of site-specific deep learning models for automated OAR segmentation in craniospinal proton therapy: a geometric and dosimetric analysis. PG - 105872 LID - S1120-1797(26)00159-6 [pii] LID - 10.1016/j.ejmp.2026.105872 [doi] AB - PURPOSE: This study evaluated the feasibility of integrating RayStation deep learning auto-segmentation (DLS) models-originally trained for adult head and neck (HN), thorax-abdomen (TA), and male pelvis (MP) regions-for automated organs-at-risk (OARs) delineation in craniospinal irradiation (CSI) with intensity-modulated-proton-therapy (IMPT), focusing on geometric accuracy, dosimetric impact, and clinical efficiency. METHODS: Forty patients (aged 2-28 years) with CNS embryonal tumors were retrospectively analyzed. Their planning CT datasets were sequentially processed through the HN, TA, and MP DLS models to auto-segment 60 OARs. Thirty-one OARs were compared with expert contours using Dice Similarity Coefficient (DSC) and Hausdorff Distance (HD). Spearman's rank correlation was used to examine associations between geometric metrics and patient age, BMI, and craniospinal length. Dosimetric evaluation was performed by recalculating IMPT plans on DLS-derived OARs. RESULTS: The mean auto-segmentation time was 4.9 +/- 1.0 min per patient. Across 31 OARs, mean DSC and HD were 0.73 and 2.45 mm, with 41.9 % and 93.5 % meeting good geometric criteria (DSC > 0.8, HD < 4 mm). Geometric accuracy showed significant correlations (p < 0.05) with age, BMI, and craniospinal length for up to 11 OARs. Accuracy decreased in children (<12 years), especially for the thyroid, bowel, and pelvic structures. Mean and maximum dose deviations were within 105 and 190 cGy(RBE), except for the mandible, esophagus, and anorectum. CONCLUSION: The integrated DLS framework achieved reliable geometric and dosimetric performance across most OARs with substantial efficiency gains, offering a practical solution for rapid, standardization of CSI planning workflows under expert review. CI - Copyright (c) 2026 Associazione Italiana di Fisica Medica e Sanitaria. Published by Elsevier Ltd. All rights reserved. FAU - Gayen, Sanjib AU - Gayen S AD - Department of Medical Physics, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - Sharma, Dayananda Shamurailatpam AU - Sharma DS AD - Department of Medical Physics, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. Electronic address: drdayananda_s@apollohospitals.com. FAU - Singh, Gaganpreet AU - Singh G AD - Department of Medical Physics, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - Krishnan, Ganapathy AU - Krishnan G AD - Department of Medical Physics, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - Arjunan, Manikandan AU - Arjunan M AD - Department of Medical Physics, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - Mahammood, Suhail AU - Mahammood S AD - Department of Medical Physics, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - S, Rangasamy AU - S R AD - Department of Medical Physics, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - M, Shakthivel AU - M S AD - Department of Radiation Oncology, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - Krishna, Uday AU - Krishna U AD - Department of Radiation Oncology, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - Sundar, Sham AU - Sundar S AD - Department of Radiation Oncology, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - Chilukuri, Srinivas AU - Chilukuri S AD - Department of Radiation Oncology, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. FAU - Jalali, Rakesh AU - Jalali R AD - Department of Radiation Oncology, Apollo Proton Cancer Centre, Chennai, Tamil Nadu, India. LA - eng PT - Journal Article DEP - 20260713 PL - Italy TA - Phys Med JT - Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) JID - 9302888 SB - IM MH - Humans MH - *Proton Therapy/adverse effects MH - Child MH - Child, Preschool MH - *Craniospinal Irradiation/adverse effects MH - Adolescent MH - *Organs at Risk/radiation effects MH - Radiometry MH - *Deep Learning MH - Male MH - Adult MH - Radiotherapy Dosage MH - Young Adult MH - Radiotherapy Planning, Computer-Assisted/methods MH - Automation MH - Retrospective Studies MH - *Image Processing, Computer-Assisted/methods MH - Female OTO - NOTNLM OT - Craniospinal Irradiation OT - Deep learning auto-segmentation OT - Proton beam therapy COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/14 04:10 MHDA- 2026/08/08 00:40 CRDT- 2026/07/13 18:04 PHST- 2025/10/07 00:00 [received] PHST- 2026/05/07 00:00 [revised] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/08/08 00:40 [medline] PHST- 2026/07/14 04:10 [pubmed] PHST- 2026/07/13 18:04 [entrez] AID - S1120-1797(26)00159-6 [pii] AID - 10.1016/j.ejmp.2026.105872 [doi] PST - ppublish SO - Phys Med. 2026 Aug;148:105872. doi: 10.1016/j.ejmp.2026.105872. Epub 2026 Jul 13. PMID- 42441631 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260820 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Capturing women's bodily experiences: Conception and formative stages of the women's somatic experience inventory. PG - e0353167 LID - 10.1371/journal.pone.0353167 [doi] LID - e0353167 AB - Assessment of women's bodily experiences is used primarily to characterize negative psychological features of menstruation. However, women's somatic states span a full spectrum of valence, emanate from multiple body systems, and affect physical and psychological well-being every day, throughout life and a more complete understanding of these states is important for the advancement of the science of women. This study presents the conception and formative stages of a comprehensive inventory about women's somatic states, bodily experiences, and physical perceptions to be called the Women's Somatic Experience Inventory. Three hundred biologically female university students (ages 18-25) rated the frequency and valence of diverse somatic experiences. An iterative approach was used: a systematic review compiled somatic items, variable clustering techniques reduced items, and confirmatory factor analysis and structural equation modeling guided factor refinement and proof-of-concept. Nine unpleasant latent factors (Kinesthetic Disconnect, Generalized Pain, Gastrointestinal Distress, Illness, Low Energy, Neurological Discomfort, Metabolic Stress, Heat & Urgency Response, and Sympathetic Activation) and four pleasant latent factors (Physical Alignment, Physical Intimacy, Activated & Attractive, and Parasympathetic Activation) were identified. Validated surveys of premenstrual symptoms and body awareness, use of hormonal contraception, and exercise and alcohol use behaviors were associated with pleasant and unpleasant factors, serving as initial proof-of-concept. These results support further refinement of the factors to be included in the inventory. With further testing and validation, the identified 73 somatic items and 13 factors could form the Women's Somatic Experience Inventory, the first comprehensive inventory for understanding women's somatic experiences, how these experiences change across female reproductive life stages, and how they interact with lifestyle behaviors. CI - Copyright: (c) 2026 Piersol et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Piersol, Kelsey L AU - Piersol KL AUID- ORCID: 0000-0002-3620-3753 AD - Department of Kinesiology and Health, Rutgers University-New Brunswick, New Jersey, United States of America. FAU - Colangelo, Amanda P AU - Colangelo AP AD - Department of Kinesiology and Health, Rutgers University-New Brunswick, New Jersey, United States of America. FAU - Buckman, Jennifer F AU - Buckman JF AUID- ORCID: 0000-0002-1898-5499 AD - Department of Kinesiology and Health, Rutgers University-New Brunswick, New Jersey, United States of America. LA - eng GR - F31 AA030178/AA/NIAAA NIH HHS/United States GR - R01 AA027017/AA/NIAAA NIH HHS/United States PT - Journal Article DEP - 20260713 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Young Adult MH - *Body Image/psychology MH - Body Satisfaction MH - Menstruation/psychology MH - Surveys and Questionnaires PMC - PMC13362119 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/13 22:44 MHDA- 2026/07/13 22:45 PMCR- 2026/07/13 CRDT- 2026/07/13 13:44 PHST- 2025/05/16 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/07/13 22:45 [medline] PHST- 2026/07/13 22:44 [pubmed] PHST- 2026/07/13 13:44 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - PONE-D-25-18681 [pii] AID - 10.1371/journal.pone.0353167 [doi] PST - epublish SO - PLoS One. 2026 Jul 13;21(7):e0353167. doi: 10.1371/journal.pone.0353167. eCollection 2026. PMID- 42440919 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260713 LR - 20260813 IS - 2673-4915 (Electronic) IS - 2673-4915 (Linking) VI - 7 DP - 2026 TI - Caries risk in toddlers: assessing oral health, microbial factors, and maternal transmission. PG - 1847228 LID - 10.3389/fdmed.2026.1847228 [doi] LID - 1847228 AB - OBJECTIVES: Caries risk begins early in life, yet few studies use intraoral cameras to assess risk in toddlers or examine multiple contributing factors. This study aimed to address this gap and conduct intraoral camera-based assessment of caries and evaluate multiple toddler risk factors, including microbial profiles, oral hygiene practices, and potential maternal transmission. METHODS: Cross-sectional data from 21 maternal-child dyads included intraoral camera assessments coded with an adapted International Caries Detection and Assessment System, saliva-based microbial tests for Streptococcus mutans (SM) and Lactobacillus (LB), and validated surveys of hygiene practices. RESULTS: Among toddlers (N = 21; mean age 3.9 years), intraoral camera use was well tolerated and produced images adequate for assessment. Reliability was good for sound teeth [Intraclass correlation coefficient (ICC) = 0.80], moderate for initial caries (ICC = 0.72), and poor for moderate-to-severe caries (ICC = 0.13). Most teeth were sound (89.0%), with 9.8% mild and 1.1% moderate decay. SM was detected in 9/20 (45.0%) and LB in 4/21 (19.0%) of toddlers. While 81% brushed twice daily, few flossed (14.3%) or used mouthwash (19%); 42.1% consumed soda at least weekly and 19% ate fast food weekly. More frequent brushing was associated with lower SM (Cramer's V = 0.54; p = .02) and LB (V = 0.48; p = .043). Mothers (N = 21; mean age 32.1) had 38.0% of teeth coded as sound, 45.0% with initial caries, and 14.0% with moderate-to-severe decay; 9/21 (42.9%) tested positive for LB and the same proportion tested positive for SM. Most brushed twice daily (81%), with 47.6% flossing and 38.1% using mouthwash. Maternal and toddler brushing frequency (V = 0.68; p = .02), fast-food intake (V = 0.56; p = .01), and microbial positivity (SM: V = 0.93; p = .001; LB: V = 0.54; p = .02) were strongly related. CONCLUSIONS: Intraoral cameras with adapted ICDAS scoring were feasible for assessing caries risk in toddlers. Significant concordance between maternal and child microbial profiles suggests a potential maternal influence on early caries risk. Larger longitudinal studies are needed to clarify transmission pathways and inform prevention strategies. CI - (c) 2026 Scudero, Manning, Mariscal, McNulty, Fidopiastis, Fardanesh, Heaney and Phelan. FAU - Scudero, Emma AU - Scudero E AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. FAU - Manning, Nolan AU - Manning N AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. FAU - Mariscal, Vanessa T AU - Mariscal VT AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. FAU - McNulty, Molly AU - McNulty M AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. FAU - Fidopiastis, Pat AU - Fidopiastis P AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. FAU - Fardanesh, Navid AU - Fardanesh N AD - Community Health Centers of the Central Coast, San Luis Obispo, CA, United States. FAU - Heaney, Casey AU - Heaney C AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. FAU - Phelan, Suzanne AU - Phelan S AD - Center for Health Research, California Polytechnic State University, San Luis Obispo, CA, United States. LA - eng PT - Journal Article DEP - 20260622 PL - Switzerland TA - Front Dent Med JT - Frontiers in dental medicine JID - 101777956 PMC - PMC13333731 OTO - NOTNLM OT - ICDAS OT - intraoral camera OT - maternal transmission OT - oral health OT - toddler COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/13 23:35 MHDA- 2026/07/13 23:36 PMCR- 2026/06/22 CRDT- 2026/07/13 12:32 PHST- 2026/04/06 00:00 [received] PHST- 2026/06/01 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/07/13 23:36 [medline] PHST- 2026/07/13 23:35 [pubmed] PHST- 2026/07/13 12:32 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.3389/fdmed.2026.1847228 [doi] PST - epublish SO - Front Dent Med. 2026 Jun 22;7:1847228. doi: 10.3389/fdmed.2026.1847228. eCollection 2026. PMID- 42440723 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260713 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Morphofunctional markers to assess disease-related pediatric malnutrition at admission and their association with length of hospital stay. PG - 1741856 LID - 10.3389/fnut.2026.1741856 [doi] LID - 1741856 AB - BACKGROUND: Disease-related malnutrition (DRM) occurs due to energy imbalance caused by increased catabolism, decreased appetite, or increased energy losses. In hospitalized patients, the presence of DRM can increase morbidity, disability, and mortality, as well as delay recovery from the disease. Therefore, identifying accurate nutritional markers associated with length of stay (LOS) in pediatric patients is important. OBJECTIVE: The objective of this study was to explore the association between morphofunctional markers used to evaluate DRM upon hospital admission and LOS in pediatric patients. METHODS: Exploratory, single-center prospective cohort study was performed in a single center study with patients evaluated within 24-48 h of a third level pediatric hospital. Upon hospital admission, nutritional risk was determinate risk nutritional status screening, anthropometric measurements were made such as weight, height, mid-upper arm circumference (MUAC), calf circumference (CC); body composition with bioelectrical impedance analysis (BIA) and handgrip strength (HGS) was carried out. DRM was diagnosed based on body mass index-for-age z-score (BMIz) < -2 standard deviations (SD). RESULTS: A total of 139 pediatric patients (mean age 12.1 +/- 3.3 years) were included; DRM was present in 15.8%. Among patients with DRM, those who concomitantly presented low phase angle (PhA), low CC, and low HGS had a significantly longer median LOS [15 (5-27) days] than those with values above the established cutoff points [(8 (5-13) days], (p = 0.029). CONCLUSION: In pediatric patients with DRM, lower levels of morphofunctional markers (PhA, HGS, and CC) at hospital admission were associated with prolonged hospital stay. These findings, derived from a Mexican pediatric population, warrant external validation in larger and more diverse cohorts. CI - Copyright (c) 2026 Garcia-Guzman, Pinzon-Navarro, Baldwin-Monroy, Ortiz-Gutierrez, Guevara-Cruz, Avila-Nava and Medina-Vera. FAU - Garcia-Guzman, Alda Daniela AU - Garcia-Guzman AD AD - Servicio de Oncologia Medica, Instituto Nacional de Pediatria, Ciudad de Mexico, Mexico. AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de Mexico, Mexico. FAU - Pinzon-Navarro, Beatriz Adriana AU - Pinzon-Navarro BA AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de Mexico, Mexico. AD - Servicio de Gastroenterologia y Nutricion Pediatrica, Instituto Nacional de Pediatria, Ciudad de Mexico, Mexico. FAU - Baldwin-Monroy, Daffne Danae AU - Baldwin-Monroy DD AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de Mexico, Mexico. AD - Unidad de Terapia Intensiva, Instituto Nacional de Pediatria, Ciudad de Mexico, Mexico. FAU - Ortiz-Gutierrez, Salvador AU - Ortiz-Gutierrez S AD - Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Mexico. AD - Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina, Instituto Politecnico Nacional (IPN), Ciudad de Mexico, Mexico. FAU - Guevara-Cruz, Martha AU - Guevara-Cruz M AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de Mexico, Mexico. AD - Departamento de Fisiologia de la Nutricion, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Ciudad de Mexico, Mexico. FAU - Avila-Nava, Azalia AU - Avila-Nava A AD - Hospital Regional de Alta Especialidad Peninsula de Yucatan, Servicios de Salud del Instituto Mexicano del Seguro Social para el Bienestar (IMSS-Bienestar), Merida, Yucatan, Mexico. FAU - Medina-Vera, Isabel AU - Medina-Vera I AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Ciudad de Mexico, Mexico. AD - Departamento de Metodologia de la Investigacion, Instituto Nacional de Pediatria, Ciudad de Mexico, Mexico. LA - eng PT - Journal Article DEP - 20260622 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13333472 OTO - NOTNLM OT - body composition OT - disease-related malnutrition OT - hospital admission OT - pediatric OT - phase angle COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author MG-C declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/07/13 22:43 MHDA- 2026/07/13 22:44 PMCR- 2026/06/22 CRDT- 2026/07/13 12:24 PHST- 2025/11/07 00:00 [received] PHST- 2026/05/12 00:00 [revised] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/07/13 22:44 [medline] PHST- 2026/07/13 22:43 [pubmed] PHST- 2026/07/13 12:24 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.3389/fnut.2026.1741856 [doi] PST - epublish SO - Front Nutr. 2026 Jun 22;13:1741856. doi: 10.3389/fnut.2026.1741856. eCollection 2026. PMID- 42440670 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Associations of smartphone addiction and physical activity with sleep quality and neck/shoulder symptoms in university students: a cross-sectional study. PG - 1848640 LID - 10.3389/fpubh.2026.1848640 [doi] LID - 1848640 AB - OBJECTIVE: To examine the associations of smartphone addiction, physical activity, and sedentary time with sleep quality and neck/shoulder symptoms during the previous 7 days in university students, and to assess the potential modifying role of physical activity in outcomes associated with smartphone addiction. METHODS: A cross-sectional survey was conducted among 585 students from a single university in Jilin Province, China. Smartphone addiction, physical activity, sedentary time, sleep quality, and neck/shoulder symptoms were assessed using validated questionnaires. Multivariable linear regression and Poisson regression with robust variance were used to examine adjusted associations and interaction terms. RESULTS: Of the participants, 43.8% were classified as having poor sleep, and 46.2% reported at least one neck/shoulder symptoms during the previous 7 days. After adjustment for covariates, higher smartphone addiction and longer sedentary time were both associated with higher PSQI scores, a higher prevalence of poor sleep, and a higher prevalence of neck/shoulder symptoms during the previous 7 days. Meeting physical activity recommendations was associated with lower PSQI scores and a lower prevalence of poor sleep, but showed no independent association with neck/shoulder symptoms. After further adjustment for PSQI, smartphone addiction, sedentary time, and PSQI score were still significantly associated with a higher prevalence of neck/shoulder symptoms. Interaction plots showed descriptively lower predicted PSQI scores and lower predicted probabilities of neck/shoulder symptoms among students who met physical activity recommendations at comparable levels of smartphone addiction; however, the formal interaction terms were not statistically significant. CONCLUSION: Smartphone addiction and sedentary time were consistently associated with poorer sleep quality and more frequent neck/shoulder symptoms. Physical activity was more consistently associated with sleep outcomes than with neck/shoulder symptoms. These findings support considering smartphone use, sedentary behaviour, physical activity, and sleep management together in campus health promotion research. CI - Copyright (c) 2026 Yue, Cao, Zhao, Wang, Lai, Zhang and Cui. FAU - Yue, Wei AU - Yue W AD - College of Physical Education, Jilin Normal University, Siping, Jilin, China. FAU - Cao, Shen AU - Cao S AD - Football School, Hebei Institute of Communications, Shijiazhuang, Hebei, China. FAU - Zhao, Jinglei AU - Zhao J AD - School of Culture, Tourism, Health and Wellness Education, Dongying Vocational College, Dongying, Shandong, China. FAU - Wang, Qin AU - Wang Q AD - School of Culture, Tourism, Health and Wellness Education, Dongying Vocational College, Dongying, Shandong, China. FAU - Lai, Weigang AU - Lai W AD - Sports Committee, Dongying Vocational College, Dongying, China. FAU - Zhang, Jinhui AU - Zhang J AD - Faculty of Education and Liberal Studies, City University Malaysia, Kuala Lumpur, Malaysia. FAU - Cui, Yuexin AU - Cui Y AD - Office of Academic Affairs, Dongying Vocational College, Dongying, China. LA - eng PT - Journal Article DEP - 20260622 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - *Students/statistics & numerical data/psychology MH - *Exercise MH - Male MH - Universities MH - *Shoulder Pain/epidemiology MH - *Sleep Quality MH - China/epidemiology MH - *Smartphone/statistics & numerical data MH - Young Adult MH - *Neck Pain/epidemiology MH - Surveys and Questionnaires MH - Sedentary Behavior MH - Adult MH - Adolescent MH - *Internet Addiction Disorder/epidemiology PMC - PMC13333704 OTO - NOTNLM OT - neck/shoulder symptoms OT - physical activity OT - sedentary behaviour OT - sleep quality OT - smartphone addiction COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/13 23:35 MHDA- 2026/07/13 23:36 PMCR- 2026/06/22 CRDT- 2026/07/13 12:22 PHST- 2026/04/06 00:00 [received] PHST- 2026/05/19 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/07/13 23:36 [medline] PHST- 2026/07/13 23:35 [pubmed] PHST- 2026/07/13 12:22 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1848640 [doi] PST - epublish SO - Front Public Health. 2026 Jun 22;14:1848640. doi: 10.3389/fpubh.2026.1848640. eCollection 2026. PMID- 42439710 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 2047-7163 (Electronic) IS - 0036-8504 (Print) IS - 0036-8504 (Linking) VI - 109 IP - 3 DP - 2026 Jul-Sep TI - Diagnostic accuracy of ultrasound-based fetal weight estimation and prediction modeling for low birth weight: A retrospective cohort study in Northwest Ethiopia. PG - 368504261468514 LID - 10.1177/00368504261468514 [doi] LID - 00368504261468514 AB - ObjectiveTo evaluate the accuracy of ultrasound-based fetal weight estimation and to develop and internally validate a prediction model for low birth weight.MethodsA retrospective cohort study was conducted among 269 individuals.ResultsThe accuracy of ultrasound weight estimation was 72.9%, with 27.1% of estimates falling outside +/-10% of actual birth weight. The Pearson correlation for estimated fetal weight and actual birth weight was 0.92. Using LASSO regression eight predictors were selected and entered in the multivariable analysis of which gestational age, estimated fetal weight, timing of estimation, and placental location were found significant. The original model demonstrated strong discrimination of AUC of 95.9% 95%CI (93.1-98.0%), and good calibration. Internal validation via 1000-bootstrap resampling yielded a bias-corrected AUC of 94.3%, indicating preserved predictive performance with minimal optimism. An integer-based risk score was derived to enhance clinical usability. The risk score model achieved acceptable discrimination (AUC = 76.8%, 95% CI: 70.0-83.0%) and good calibration (p = 0.301). Agreement between the full prediction model and the simplified risk score was fair (Cohen's Kappa = 0.353, p < 0.0001), indicating that the simplified score is best suited as a pragmatic bedside risk-stratification tool rather than a direct substitute for the full model. Women were stratified into low (0-10 points), medium (11-21), and high-risk (22-36) groups corresponding to increasing predicted probabilities of low birth weight (3.2%-96.3%).ConclusionUltrasound-based fetal weight estimation using the Hadlock-III formula indicated acceptable accuracy and strong correlation with actual birth weight. We developed and internally validated prediction model for low birth weight with excellent discrimination, good calibration, and predictive value beyond estimated fetal weight alone. A risk-score tool was created to facilitate rapid bedside risk stratification. However, given the single-center nature of the study and the absence of external validation, further multicenter validation is required before broader clinical implementation. FAU - Mekonin, Amsalu Worku AU - Mekonin AW AD - Department of Obstetrics and Gynecology, College of Medicine and Health Sciences Bahir Dar University, Bahir Dar, Ethiopia. FAU - Debas, Sintayehu AU - Debas S AD - Department of Obstetrics and Gynecology, College of Medicine and Health Sciences Bahir Dar University, Bahir Dar, Ethiopia. FAU - Fenta, Haile Mekonnen AU - Fenta HM AD - Department of Statistics, College of Natural Sciences Bahir Dar University, Bahir Dar, Ethiopia. FAU - Wubie, Yihun Miskir AU - Wubie YM AD - Departments of Adult Nursing, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia. RINGGOLD: 128158 FAU - Zegeye, Asres AU - Zegeye A AD - Sirinka Agricultural Research Center, Amhara Agricultural Research Institute, Bahir Dar, Ethiopia. FAU - Anteneh, Zelalem Alamrew AU - Anteneh ZA AUID- ORCID: 0000-0003-4879-675X AD - Departments of Epidemiology and Biostatistics, College of Medicine and Health Sciences, Bahir Dar University, Bahir Dar, Ethiopia. RINGGOLD: 128158 LA - eng PT - Journal Article DEP - 20260713 PL - England TA - Sci Prog JT - Science progress JID - 0411361 SB - IM MH - Humans MH - Female MH - *Fetal Weight MH - Retrospective Studies MH - *Ultrasonography, Prenatal/methods MH - Pregnancy MH - *Infant, Low Birth Weight MH - Ethiopia MH - Adult MH - Infant, Newborn MH - Gestational Age MH - Prediction Algorithms MH - Birth Weight PMC - PMC13457155 OTO - NOTNLM OT - accuracy OT - estimated fetal weight OT - low birth weight OT - risk prediction OT - ultrasound COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/07/13 12:35 MHDA- 2026/07/13 12:36 PMCR- 2026/07/13 CRDT- 2026/07/13 09:43 PHST- 2026/07/13 12:36 [medline] PHST- 2026/07/13 12:35 [pubmed] PHST- 2026/07/13 09:43 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - 10.1177_00368504261468514 [pii] AID - 10.1177/00368504261468514 [doi] PST - ppublish SO - Sci Prog. 2026 Jul-Sep;109(3):368504261468514. doi: 10.1177/00368504261468514. Epub 2026 Jul 13. PMID- 42438849 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260713 LR - 20260813 IS - 2733-7545 (Electronic) IS - 2733-7545 (Linking) VI - 30 IP - 2 DP - 2026 Jun TI - Screening for insulin resistance in children with abdominal obesity: sex-specific performance of TyG index, FGIR, and VAI. PG - 90-98 LID - 10.20463/pan.2026.0026 [doi] AB - PURPOSE: This study aimed to compare the diagnostic performance of the triglyceride-glucose index (TyG), fasting glucose-to-insulin ratio (FGIR), and visceral adiposity index (VAI) for detecting insulin resistance (IR) and to establish sex-specific IR cutoffs in Korean schoolchildren with abdominal obesity. METHODS: This cross-sectional study included 728 fourth- to sixth-grade students (398 boys and 330 girls; mean age, 11.5 +/- 1.1 years) from P City, Gyeonggi-do (June 2018-August 2019). Abdominal obesity was defined as waist circumference and waist-to-height ratio >/= 90th percentile (high-risk subgroup, n = 192). IR was classified using sex-specific homeostasis model assessment of insulin resistance cutoffs (boys >/= 3.54, girls >/= 3.69). Receiver operating characteristic analysis with the Youden index was performed to compare TyG index, FGIR, and VAI in the high-risk subgroup. RESULTS: FGIR demonstrated superior performance in both sexes. The area under the curve (AUC) was 0.939 (95% confidence interval [CI], 0.903-0.976) for boys and 0.894 (95% CI, 0.835-0.954) for girls. Corresponding cutoff values were 8.435 and 7.473, with sensitivities of 94.9% and 91.2% and specificities of 79.6% and 81.2%, respectively. TyG and VAI exhibited lower AUCs (0.726‒0.768 and 0.679‒0.740, respectively). High-risk abdominal obesity was strongly associated with IR (adjusted odds ratio 6.175, 95% CI, 3.958-9.633). CONCLUSION: Among Korean school-aged children with abdominal obesity, FGIR outperformed TyG and VAI as surrogate markers of IR. Accounting for pubertal insulin dynamics with sex-specific cutoff values supports the use of FGIR as a practical, low-cost tool for early screening and intervention in high-risk groups. FAU - Jin, Youngyun AU - Jin Y AD - Department of Sport Science, Sungkyunkwan University, Suwon, Republic of Korea. FAU - Kim, Donghyun AU - Kim D AD - Department of Sport and Health Science, National Hanbat University, Daejeon, Republic of Korea. hyun0714@hanbat.ac.kr. AD - Department of Big Data and Healthcare Convergence, National Hanbat University, Daejeon, Republic of Korea. hyun0714@hanbat.ac.kr. LA - eng PT - Journal Article DEP - 20260630 PL - Korea (South) TA - Phys Act Nutr JT - Physical activity and nutrition JID - 101770644 PMC - PMC13358607 OTO - NOTNLM OT - Abdominal Obesity OT - Fasting Glucose-to-Insulin Ratio OT - Insulin Resistance OT - School-aged children OT - Triglyceride-Glucose Index COIS- No potential conflict of interest relevant to this article was reported. EDAT- 2026/07/13 06:33 MHDA- 2026/07/13 06:34 PMCR- 2026/06/01 CRDT- 2026/07/13 03:48 PHST- 2026/04/16 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/07/13 06:34 [medline] PHST- 2026/07/13 06:33 [pubmed] PHST- 2026/07/13 03:48 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - pan.2026.0026 [pii] AID - pan-2026-0026 [pii] AID - 10.20463/pan.2026.0026 [doi] PST - ppublish SO - Phys Act Nutr. 2026 Jun;30(2):90-98. doi: 10.20463/pan.2026.0026. Epub 2026 Jun 30. PMID- 42438389 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260806 IS - 1938-744X (Electronic) IS - 1935-7893 (Linking) VI - 20 DP - 2026 Jul 13 TI - Short-term Mental Health Changes Seen in Mothers and Play-age Children after the 2023 Turkiye-Syria Earthquakes. PG - e130 LID - 10.1017/dmp.2026.10404 [doi] AB - OBJECTIVE: To evaluate the mental health of play-age children affected by the 2023 Turkiye-Syria earthquakes and their mothers, using single-item scales. METHODS: Four hundred earthquake survivor mother-child dyads were included. The mental health of mothers and children was assessed using single-item screening tools, the Self-Reported Mother Mental Health (SRMH) and the Mother-Reported Child Mental Health (MRCMH). RESULTS: The prevalence of negative mental health increased from 10% to 52% in play-age children and from 13% to 70% in their mothers after the earthquakes. For post-earthquake negative SRMH, associated factors included limited access to safe water (AOR = 2.52, 95% CI: 1.10-5.75, P = 0.029), good perception of security services (AOR = 0.30, 95% CI: 0.12-0.73, P = 0.008), and post-earthquake negative MRCMH (AOR = 8.65, 95% CI: 4.70-15.91, P < 0.001). For post-earthquake negative MRCMH, associated factors were out-of-house sheltering (AOR = 3.13, 95% CI: 1.72-5.69, P < 0.001), good perception of nutritional services (AOR = 0.46, 95% CI: 0.22-0.96, P = 0.039), pre-earthquake negative MRCMH (AOR = 4.68, 95% CI: 1.87-11.73, P = 0.001), and post-earthquake negative SRMH (AOR = 11.35, 95% CI: 5.92-21.76, P < 0.001). CONCLUSION: Post-earthquake mental health outcomes were most consistently predicted by limited basic resources (water and nutrition services), not good service quality, and pre-existing or co-occurring negative mental health. FAU - Tezol, Ozlem AU - Tezol O AUID- ORCID: 0000-0001-9994-7832 AD - Pediatrics Department, https://ror.org/04nqdwb39School of Medicine, Mersin University, Mersin, Turkiye. FAU - Yalcin, Siddika Songul AU - Yalcin SS AD - Social Pediatrics Department, https://ror.org/04kwvgz42School of Medicine, Hacettepe University, Ankara, Turkiye. FAU - Gunes, Bulent AU - Gunes B AD - Pediatrics Department, https://ror.org/057qfs197School of Medicine, Harran University, Sanliurfa, Turkiye. FAU - Almis, Habip AU - Almis H AD - Social Pediatrics Department, https://ror.org/030z8x523Sincan Training and Research Hospital, Health Sciences University, Ankara, Turkiye. FAU - Barutcu, Adnan AU - Barutcu A AUID- ORCID: 0000-0001-8930-1122 AD - Social Pediatrics Department, https://ror.org/05wxkj555School of Medicine, Cukurova University, Adana, Turkiye. FAU - Erat Nergiz, Meryem AU - Erat Nergiz M AD - Pediatrics Department, School of Medicine, Ankara Yildirim Beyazit University, Ankara Yenimahalle Education and Research Hospital, Ankara, Turkiye. FAU - Orun, Emel AU - Orun E AUID- ORCID: 0000-0002-7596-5603 AD - Social Pediatrics Department, https://ror.org/01nk6sj42Ankara Etlik City Hospital, Health Sciences University, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260713 PL - United States TA - Disaster Med Public Health Prep JT - Disaster medicine and public health preparedness JID - 101297401 SB - IM MH - Humans MH - *Earthquakes/statistics & numerical data MH - Female MH - *Mothers/psychology/statistics & numerical data MH - *Mental Health/statistics & numerical data MH - Child MH - Male MH - Adult MH - Surveys and Questionnaires MH - Child, Preschool MH - Survivors/psychology/statistics & numerical data MH - Psychometrics/instrumentation/methods OTO - NOTNLM OT - Earthquake OT - mental health OT - play-age children EDAT- 2026/07/13 06:32 MHDA- 2026/07/13 06:33 CRDT- 2026/07/13 03:22 PHST- 2026/07/13 06:33 [medline] PHST- 2026/07/13 06:32 [pubmed] PHST- 2026/07/13 03:22 [entrez] AID - S1935789326104042 [pii] AID - 10.1017/dmp.2026.10404 [doi] PST - epublish SO - Disaster Med Public Health Prep. 2026 Jul 13;20:e130. doi: 10.1017/dmp.2026.10404. PMID- 42438229 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260922 IS - 1365-2834 (Electronic) IS - 0966-0429 (Print) IS - 0966-0429 (Linking) VI - 2026 IP - 1 DP - 2026 TI - Quantitative Threshold Analysis: Assessing Breastfeeding's Protective Impact on Bronchopulmonary Dysplasia in Preterm Infants. PG - e5560949 LID - 10.1155/jonm/5560949 [doi] LID - 5560949 AB - OBJECTIVE: This study aims to thoroughly investigate the protective effects of various breastfeeding rates on bronchopulmonary dysplasia (BPD), clarify the relationship between them, and further determine the minimum protective threshold. METHODS: This prospective study enrolled 276 preterm infants who were born in the obstetrics department of a tertiary Grade A hospital in Zhejiang, China, and were directly admitted to the NICU. RESULTS: This study involved 276 infants, categorized into three breastfeeding groups based on proportion: low (100 infants, 36.2%), medium (98 infants, 35.5%), and high (78 infants, 28.3%). Notably, the incidence of BPD in the high-proportion breastfeeding group (19.5%) was significantly lower than that in the medium-proportion group (44.5%) and the low-proportion group (55%) (p < 0.05); however, there was no statistically significant difference in the incidence of BPD between the medium-proportion group and the low-proportion group (p > 0.05). Exploratory nonlinear analyses suggested a possible candidate inflection point around 0.31, above which the inverse association between breastfeeding proportion and BPD appeared stronger. CONCLUSION: Breastfeeding plays a crucial role in protecting premature infants from BPD. However, this protective effect does not increase linearly but becomes significant only when the breastfeeding rate reaches 31%. However, this threshold-related finding should be interpreted cautiously and requires validation in larger studies with more comprehensive confounder adjustment. CI - Copyright (c) 2026 Mengqing Pan et al. Journal of Nursing Management published by John Wiley & Sons Ltd. FAU - Pan, Mengqing AU - Pan M AUID- ORCID: 0009-0008-1593-2552 AD - Department of Neonatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China, wmu.edu.cn. AD - School of Nursing, Wenzhou Medical University, Wenzhou, China, wmu.edu.cn. FAU - Chen, Yijia AU - Chen Y AUID- ORCID: 0009-0003-7139-8140 AD - Department of Neonatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China, wmu.edu.cn. AD - School of Nursing, Wenzhou Medical University, Wenzhou, China, wmu.edu.cn. FAU - Lu, Xiaoyu AU - Lu X AUID- ORCID: 0009-0007-2557-5862 AD - School of Nursing, Wenzhou Medical University, Wenzhou, China, wmu.edu.cn. FAU - Liu, Chuntian AU - Liu C AUID- ORCID: 0009-0002-5623-2671 AD - School of Nursing, Wenzhou Medical University, Wenzhou, China, wmu.edu.cn. FAU - Hu, Xiaojing AU - Hu X AUID- ORCID: 0000-0003-0537-7475 AD - Department of Neonatology, Children's Hospital of Fudan University, Shanghai, China, fudan.edu.cn. FAU - Chen, Xiaochun AU - Chen X AUID- ORCID: 0000-0003-3385-7230 AD - Department of Neonatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China, wmu.edu.cn. LA - eng GR - Y2023049/Wenzhou Municipal Science and Technology Bureau/ PT - Journal Article PL - England TA - J Nurs Manag JT - Journal of nursing management JID - 9306050 SB - IM EIN - J Nurs Manag. 2026;2026(1):e9851543. doi: 10.1155/jonm/9851543. PMID: 42754966 MH - Humans MH - *Breast Feeding/statistics & numerical data/methods MH - *Bronchopulmonary Dysplasia/prevention & control/epidemiology MH - Infant, Newborn MH - Female MH - Prospective Studies MH - *Infant, Premature MH - China/epidemiology MH - Male MH - Incidence MH - Intensive Care Units, Neonatal/organization & administration/statistics & numerical data PMC - PMC13358207 OTO - NOTNLM OT - breastfeeding OT - bronchopulmonary dysplasia OT - preterm infants OT - protective OT - threshold analysis COIS- The authors declare no conflicts of interest. EDAT- 2026/07/13 06:33 MHDA- 2026/07/13 06:34 PMCR- 2026/07/12 CRDT- 2026/07/13 01:53 PHST- 2026/05/01 00:00 [revised] PHST- 2025/05/21 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/07/13 06:34 [medline] PHST- 2026/07/13 06:33 [pubmed] PHST- 2026/07/13 01:53 [entrez] PHST- 2026/07/12 00:00 [pmc-release] AID - JONM5560949 [pii] AID - 10.1155/jonm/5560949 [doi] PST - ppublish SO - J Nurs Manag. 2026;2026(1):e5560949. doi: 10.1155/jonm/5560949. PMID- 42438127 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 1746-1561 (Electronic) IS - 0022-4391 (Print) IS - 0022-4391 (Linking) VI - 96 IP - 8 DP - 2026 Aug TI - Enhancing Motor Competence in Rhythmic Gymnastics: Effects of the Overlapping Waves Strategy in School-Based Physical Education. PG - e70195 LID - 10.1111/josh.70195 [doi] LID - e70195 AB - BACKGROUND: Rhythmic gymnastics offers a context for motor development. This study examined the association between the Overlapping Waves Strategy and traditional instruction in fundamental club skills. METHODS: A cluster-allocated quasi-experimental design (16 sessions) was implemented among 64 fifth-grade female students. Participants received Overlapping Waves Strategy (n = 32) or conventional instruction (n = 32). Four skills were assessed by certified judges. RESULTS: Two-way mixed ANOVA revealed significant group x time interactions (all p < 0.001). The experimental group exhibited greater pre-post performance gains than the control group. Implications for School Health Policy, Practice, and Equity: The strategy provides a structured pedagogical framework for physical education, suggesting potential feasibility, though limited by the specific single-setting and demographic parameters, and policy recommendations remain premature without broader replication. CONCLUSION: Preliminary findings indicate greater short-term execution of club skills in the experimental classroom. Classroom-level confounding cannot be excluded. Replication in cluster-randomized designs with retention measures is required. CI - (c) 2026 American School Health Association. FAU - Hamza, Ghofran Basheer AU - Hamza GB AD - Department of Individual Games, College of Physical Education and Sports Sciences for Women, University of Baghdad, Baghdad, Iraq. FAU - Sherkhan, Lena Ali AU - Sherkhan LA AD - Department of Individual Games, College of Physical Education and Sports Sciences for Women, University of Baghdad, Baghdad, Iraq. FAU - Ghouili, Hatem AU - Ghouili H AD - Research Unit "Sport Sciences, Health and Movement," High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. FAU - Yahya, Suhair Raad AU - Yahya SR AD - Department of Individual Games, College of Physical Education and Sports Sciences for Women, University of Baghdad, Baghdad, Iraq. FAU - Muntean, Raul Ioan AU - Muntean RI AUID- ORCID: 0000-0003-4615-6687 AD - Department of Physical Education and Sport, University "1 Decembrie 1918" of Alba Iulia, Alba Iulia, Romania. FAU - Ceylan, Halil Ibrahim AU - Ceylan HI AUID- ORCID: 0009-0005-2214-4667 AD - Physical Education of Sports Teaching Department, Faculty of Kazim Karabekir Education, Ataturk University, Erzurum, Turkiye. FAU - Stefanica, Valentina AU - Stefanica V AUID- ORCID: 0000-0003-4031-1412 AD - Department of Physical Education and Sport, Faculty of Sciences, Physical Education and Informatics, National University of Science and Technology Politehnica Bucharest, Pitesti University Center, Pitesti, Romania. FAU - Al-Selmi, Abeer Dakhil Hatem AU - Al-Selmi ADH AD - Department of Individual Games, College of Physical Education and Sports Sciences for Women, University of Baghdad, Baghdad, Iraq. FAU - Mohamood, Marwa Saadi AU - Mohamood MS AD - Department of Individual Games, College of Physical Education and Sports Sciences for Women, University of Baghdad, Baghdad, Iraq. FAU - Dhahbi, Wissem AU - Dhahbi W AUID- ORCID: 0000-0001-6221-546X AD - Research Unit "Sport Sciences, Health and Movement," High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. AD - Training Department, Qatar Police Academy, Police College, Doha, Qatar. FAU - Benezzeddine, Lamia AU - Benezzeddine L AD - High Institute of Sport and Physical Education of Ksar Said, University of Manouba, Manouba, Tunisia. LA - eng PT - Journal Article PL - United States TA - J Sch Health JT - The Journal of school health JID - 0376370 SB - IM MH - Humans MH - *Gymnastics/education/physiology MH - *Physical Education and Training/methods/organization & administration MH - Female MH - *Motor Skills/physiology MH - Child MH - *School Health Services/organization & administration MH - Schools PMC - PMC13358179 OTO - NOTNLM OT - cooperative learning OT - fundamental movement skills OT - motor competence OT - motor development OT - physical literacy OT - rhythmic gymnastics OT - school-based intervention COIS- The authors declare no conflicts of interest. EDAT- 2026/07/13 10:09 MHDA- 2026/07/13 10:10 PMCR- 2026/07/13 CRDT- 2026/07/13 00:53 PHST- 2026/05/22 00:00 [revised] PHST- 2025/09/24 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/07/13 10:10 [medline] PHST- 2026/07/13 10:09 [pubmed] PHST- 2026/07/13 00:53 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - JOSH70195 [pii] AID - 10.1111/josh.70195 [doi] PST - ppublish SO - J Sch Health. 2026 Aug;96(8):e70195. doi: 10.1111/josh.70195. PMID- 42437956 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261008 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 45 IP - 1 DP - 2026 Jul 12 TI - Predicting and identifying determinants of stunting among school-aged children in Ethiopia: a machine learning approach. LID - 10.1186/s41043-026-01401-y [doi] LID - 216 AB - BACKGROUND: Childhood stunting remains a major public health concern, reflecting chronic undernutrition and long-term socioeconomic disadvantage. Among school-aged children, stunting is associated with impaired physical growth, reduced cognitive development, and poorer educational outcomes. Traditional statistical approaches, such as logistic regression, have been widely used to examine factors associated with stunting; however, their ability to capture complex and nonlinear relationships is limited. Machine learning (ML) methods provide a flexible alternative for modeling such relationships. OBJECTIVE: This study aimed to model and classify stunting among school-aged children in Ethiopia using school- and household-level data, and to compare the performance of machine learning algorithms with multivariable logistic regression. METHODS: A cross-sectional analysis was conducted using secondary data from Round 5 (2016-2017) of the Young Lives study in Ethiopia. Stunting was defined as a binary outcome based on World Health Organization height-for-age Z-score criteria. Several machine learning algorithms, including Random Forest, Support Vector Machine, and Gradient Boosting Machine, were implemented. Model performance was evaluated using accuracy, sensitivity, specificity, F1-score, and area under the receiver operating characteristic curve (AUC). Variable importance measures were used to identify predictors contributing to model performance. To avoid potential circularity, anthropometric variables closely related to the outcome (e.g., child weight) were excluded from the final models. RESULTS: The Random Forest model demonstrated modestly improved performance compared with logistic regression and other machine learning methods, and its performance was evaluated using accuracy, sensitivity, specificity, AUC, and F1-score. Key predictors included school type, household wealth index, literacy-related indicators, and region of residence. Notable regional variation in stunting classification was observed, suggesting the influence of broader socioeconomic and environmental conditions. CONCLUSION: Machine learning models, particularly Random Forest, showed slightly better performance than conventional logistic regression in classifying stunting among school-aged children in Ethiopia. The identified predictors highlight the multifactorial and context-dependent nature of stunting. These findings support the use of ML approaches as complementary analytical tools for understanding patterns of child undernutrition, although their application for prediction should be interpreted within the limitations of cross-sectional data. CI - (c) 2026. The Author(s). FAU - Dugasa, Shibiru Jabessa AU - Dugasa SJ AD - Department of Statistics, Wollega University, Nekemte, Oromia, Ethiopia. shibirujabessa2021@gmail.com. FAU - Aga, Merga Abdissa AU - Aga MA AD - Department of Statistics, Salale University, Fiche, Oromia, Ethiopia. LA - eng PT - Journal Article DEP - 20260712 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Humans MH - Ethiopia/epidemiology MH - *Growth Disorders/epidemiology/etiology/diagnosis MH - Cross-Sectional Studies MH - *Machine Learning MH - Child MH - Male MH - Female MH - Predictive Learning Models MH - Random Forest MH - Classification Algorithms MH - Boosting Machine Learning Algorithms MH - Logistic Models MH - Prediction Algorithms PMC - PMC13640390 OTO - NOTNLM OT - Classification OT - Ethiopia OT - Machine learning OT - School-aged children OT - Stunting COIS- Declarations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/13 00:32 MHDA- 2026/10/07 06:25 PMCR- 2026/07/12 CRDT- 2026/07/12 23:40 PHST- 2026/01/09 00:00 [received] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/10/07 06:25 [medline] PHST- 2026/07/13 00:32 [pubmed] PHST- 2026/07/12 23:40 [entrez] PHST- 2026/07/12 00:00 [pmc-release] AID - 10.1186/s41043-026-01401-y [pii] AID - 1401 [pii] AID - 10.1186/s41043-026-01401-y [doi] PST - epublish SO - J Health Popul Nutr. 2026 Jul 12;45(1):216. doi: 10.1186/s41043-026-01401-y. PMID- 42437943 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261008 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 45 IP - 1 DP - 2026 Jul 12 TI - Associations of starchy and non-starchy vegetable intake with depression, anxiety, stress, chronotype, and sleep quality among iranian women with overweight or obesity: a cross-sectional study. LID - 10.1186/s41043-026-01392-w [doi] LID - 217 AB - BACKGROUND: Starchy vegetables may influence psychological well-being, circadian alignment, and sleep quality through their glycemic characteristics and related metabolic effects. In contrast, non‑starchy vegetables, which differ substantially in nutrient density and bioactive compounds, may affect these outcomes through alternative physiological pathways. Despite these distinct nutritional profiles, evidence comparing their separate associations with mental health and sleep-related patterns is limited. This study explored these relationships among overweight and obese women. METHODS: In this cross-sectional study, 391 overweight and obese women aged 18-48 years were recruited using a cluster sampling strategy from community health centres. Data collection was conducted through structured face‑to‑face interviews performed by trained nutritionists. Mental health indicators (depression, anxiety, and stress) were assessed using the Persian DASS‑21, sleep quality was evaluated using the PSQI, and circadian preference was measured using the MEQ. Dietary intake was obtained through a validated 147‑item food frequency questionnaire (FFQ). Anthropometric measurements, blood samples, biochemical markers, physical activity, and demographic information were collected following standardized procedures. RESULTS: The study included 391 women, with a mean age of 38.08 +/- 8.61 years in the high non-starchy vegetable intake group and 35.31 +/- 9.59 years in the low non-starchy vegetable intake group, all classified as overweight or obese. Participants with higher non‑starchy vegetable intake exhibited significantly lower odds of depression (adjusted OR = 0.40, 95% CI = 0.20-0.79, P < 0.001) and stress (adjusted OR = 0.30, 95% CI = 0.14-0.85, P = 0.02). Higher non‑starchy vegetable consumption was also associated with improved sleep quality (adjusted OR = 0.38, 95% CI = 0.19-0.77, P = 0.007). Furthermore, increased starchy vegetable intake was inversely associated with the morning-type chronotype (adjusted OR = 0.27, 95% CI = 0.09-0.83, P = 0.02) after full adjustment. CONCLUSIONS: Higher non-starchy vegetable intake was associated with lower odds of depression, stress, and poor sleep quality, while greater starchy vegetable consumption was linked to a lower likelihood of morning-type chronotype. Increasing non-starchy vegetable intake may support psychological well-being and sleep health, though longitudinal studies are needed to confirm causality. CI - (c) 2026. The Author(s). FAU - Roumi, Zahra AU - Roumi Z AD - Department of Clinical Nutrition and Dietetics , Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Mirzababaei, Atieh AU - Mirzababaei A AD - Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. ati_babaee@yahoo.com. AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. ati_babaee@yahoo.com. FAU - Abaj, Faezeh AU - Abaj F AD - Department of Nutrition, Dietetics & Food, Monash University, Notting Hill, VIC, Australia. FAU - Clark, Cain C T AU - Clark CCT AD - Centre for Intelligent Healthcare, CV1 5FB, Coventry, U.K. FAU - Jadidi, Paria AU - Jadidi P AD - Department of Nutrition, SR.C, Islamic Azad University, Tehran, Iran. FAU - Rasekhmagham, Reyhaneh AU - Rasekhmagham R AD - Department of Nutrition, SR.C, Islamic Azad University, Tehran, Iran. FAU - Mirzaei, Khadijeh AU - Mirzaei K AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. LA - eng GR - 97-03-161-41155/Tehran University of Medical Sciences and Health Services/ PT - Journal Article DEP - 20260712 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Adult MH - Iran/epidemiology MH - Middle Aged MH - *Depression/epidemiology MH - Chronotype MH - *Obesity/psychology MH - *Sleep Quality MH - *Vegetables MH - *Stress, Psychological/epidemiology MH - *Overweight/psychology MH - *Anxiety/epidemiology MH - Adolescent MH - Young Adult MH - *Diet MH - Sleep PMC - PMC13640202 OTO - NOTNLM OT - Circadian rhythm OT - Female population OT - Mental health OT - Obesity OT - Sleep quality OT - Starchy/non-starchy vegetables COIS- Declarations. Ethics approval and consent to participate: The authors and the Ethics Committee of Tehran University of Medical Sciences (IR.TUMS.VCR.REC.1398.692) have received approval for the method and protocol of the current study. Additionally, written informed consent has been obtained from all participants. Consent for publication: All authors collaborated in editing this article, and the final version was approved for submission. Furthermore, they actively participated in writing the manuscript and giving their approval to the final draft. Competing interests: The authors declare no competing interests. EDAT- 2026/07/13 04:09 MHDA- 2026/10/07 06:25 PMCR- 2026/07/12 CRDT- 2026/07/12 23:39 PHST- 2025/12/04 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/10/07 06:25 [medline] PHST- 2026/07/13 04:09 [pubmed] PHST- 2026/07/12 23:39 [entrez] PHST- 2026/07/12 00:00 [pmc-release] AID - 10.1186/s41043-026-01392-w [pii] AID - 1392 [pii] AID - 10.1186/s41043-026-01392-w [doi] PST - epublish SO - J Health Popul Nutr. 2026 Jul 12;45(1):217. doi: 10.1186/s41043-026-01392-w. PMID- 42437539 OWN - NLM STAT- MEDLINE DCOM- 20260926 LR - 20260926 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 204 DP - 2026 Nov TI - Assessment of treatment response in recurrent medulloblastoma using craniospinal MRI. PG - 113056 LID - S0720-048X(26)00404-3 [pii] LID - 10.1016/j.ejrad.2026.113056 [doi] AB - BACKGROUND: To evaluate whether quantitative craniospinal MRI assessment of baseline tumor burden provides prognostic value in patients with recurrent, previously irradiated medulloblastoma undergoing MEMMAT (Metronomic Antiangiogenic) therapy. METHODS: We analyzed craniospinal MRI of 40 patients with recurrent, previously irradiated medulloblastoma enrolled in the MEMMAT trial (April 1, 2014, and March 31, 2021). Ependymal, leptomeningeal, and local relapse lesions were retrospectively manually segmented on T1-contrast-enhanced (T1CE) and diffusion-weighted imaging (DWI) at baseline and follow-up (best response). Lesion count and volume were quantified. Bland-Altman analyses and intraclass correlation coefficients (ICC) assessed inter-sequence agreement., logistic regression evaluated associations between baseline tumor burden and progressive disease. RESULTS: Patients achieving Complete Response (n = 6/40) showed mean monthly decreases of - 12.7% in T1CE lesion count and - 12.9% in volume. Partial Response patients (n = 9/40) showed similar declines (-10.3% and - 13.0%). Stable Disease patients (n = 5/40) demonstrated minimal decreases (-0.8% and - 2.3%). Progressive Disease patients (n = 16/40) showed increases of 33.7% in lesion count and 56.2% in volume. Logistic regression indicated trends toward higher baseline tumor burden predicting PD (volume OR 1.18, p = 0.08; lesion count OR 1.05, p = 0.075). Agreement between T1CE and DWI was limited (ICC 0.35 for lesion count, 0.47 for volume), with 23% of patients misclassified using either modality alone. Survival analyses demonstrated significantly shorter overall survival in patients with baseline lesion volumes >/= 5.5 ml (log-rank p = 0.003), while a similar association for progression-free survival did not reach statistical significance (p = 0.053). CONCLUSIONS: Combined intracranial and intraspinal T1CE and intracranial DWI assessment improves response evaluation. Exploratory analyses suggested that higher baseline tumor burden may be associated with progression, although the observed associations were of borderline statistical significance and require validation in larger cohorts. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Hennenberg, Juliane AU - Hennenberg J AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria. FAU - Hofer, Leo AU - Hofer L AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria. FAU - Nemeth, Bence AU - Nemeth B AD - Faculty of Information Technology and Bionics, Pazmany Peter Catholic University Budapest, Budapest, Hungary; University Hospital Zurich, Department of Neuroradiology, Zurich, Switzerland. FAU - Vollbrecht, Carolin AU - Vollbrecht C AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria. FAU - Tukora, Greta AU - Tukora G AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria. FAU - Mayr, Lisa AU - Mayr L AD - Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Vienna, Austria. FAU - Bolotin, Jewgeni AU - Bolotin J AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria; Institute of Diagnostic and Interventional Radiology and Neuroradiology, University Hospital Essen, Essen, Germany. FAU - Zelei, Regina AU - Zelei R AD - Faculty of Information Technology and Bionics, Pazmany Peter Catholic University Budapest, Budapest, Hungary. FAU - Racz, Adrienn AU - Racz A AD - Faculty of Information Technology and Bionics, Pazmany Peter Catholic University Budapest, Budapest, Hungary. FAU - Barkhof, Frederik AU - Barkhof F AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria; NMR Research Unit, Queen Square Multiple Sclerosis Centre, Queen Square Institute of Neurology, University College London, London, United Kingdom; Department of Radiology & Nuclear Medicine, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands. FAU - Slavc, Irene AU - Slavc I AD - Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Vienna, Austria. FAU - Sabel, Magnus AU - Sabel M AD - Childhood Cancer Centre, Queen Silvia Childrens Hospital, Sahlgrenska University Hospital, and Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Lassaletta, Alvaro AU - Lassaletta A AD - Pediatric Neuro-Oncology, Hospital Infantil Universitario Nino Jesus, Madrid, Spain. FAU - Sterba, Jaroslav AU - Sterba J AD - Pediatric Oncology Department, Brno University Hospital, Brno, Czech Republic. FAU - Leblond, Pierre AU - Leblond P AD - Pediatric Oncology Unit, Oscar Lambret Cancer Center, Lille, France; Centre Leon Berard, Institut d'Hematologie et d'Oncologie Pediatrique, Lyon, France. FAU - Nyson, Karsten AU - Nyson K AD - Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark. FAU - Torsvik, Ingrid AU - Torsvik I AD - Department of Paediatric and Adolecent Medicine, Haukeland University Hospital, Bergen, Norway. FAU - Chi, Susan N AU - Chi SN AD - Pediatric Neuro-Oncology, Dana-Farber Cancer Institute, Boston, MA, United States. FAU - Schmook, Maria AU - Schmook M AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria. FAU - Furtner, Julia AU - Furtner J AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria; Research Center for Medical Image Analysis and Artificial Intelligence (MIAAI), Faculty of Medicine and Dentistry, Danube Private University, Krems-Stein, Austria. FAU - Mayerhoefer, Marius E AU - Mayerhoefer ME AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria; Department of Radiology, NYU Grossman, United States. FAU - Kasprian, Gregor AU - Kasprian G AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria. FAU - Azizi, Amedeo AU - Azizi A AD - Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Vienna, Austria. FAU - Gojo, Johannes AU - Gojo J AD - Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Vienna, Austria. FAU - Peyrl, Andreas AU - Peyrl A AD - Medical University of Vienna, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics and Comprehensive Cancer Center, Vienna, Austria. FAU - Haider, Lukas AU - Haider L AD - Medical University of Vienna, Department of Biomedical Imaging and Image-guided Therapy, Vienna, Austria; NMR Research Unit, Queen Square Multiple Sclerosis Centre, Queen Square Institute of Neurology, University College London, London, United Kingdom. Electronic address: lukas.haider@meduniwien.ac.at. LA - eng PT - Journal Article DEP - 20260709 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 RN - 0 (Angiogenesis Inhibitors) RN - 0 (Contrast Media) SB - IM MH - Humans MH - *Medulloblastoma/diagnostic imaging/drug therapy/pathology MH - Female MH - Male MH - *Neoplasm Recurrence, Local/diagnostic imaging MH - Child MH - *Magnetic Resonance Imaging/methods MH - Treatment Outcome MH - Adolescent MH - Child, Preschool MH - *Cerebellar Neoplasms/diagnostic imaging/drug therapy MH - Retrospective Studies MH - Tumor Burden MH - Angiogenesis Inhibitors/therapeutic use MH - Prognosis MH - Contrast Media OTO - NOTNLM OT - Medulloblastoma OT - Metronomic antiangiogenic therapy OT - Treatment response COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/12 18:31 MHDA- 2026/09/26 05:34 CRDT- 2026/07/12 17:59 PHST- 2026/05/01 00:00 [received] PHST- 2026/06/18 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/09/26 05:34 [medline] PHST- 2026/07/12 18:31 [pubmed] PHST- 2026/07/12 17:59 [entrez] AID - S0720-048X(26)00404-3 [pii] AID - 10.1016/j.ejrad.2026.113056 [doi] PST - ppublish SO - Eur J Radiol. 2026 Nov;204:113056. doi: 10.1016/j.ejrad.2026.113056. Epub 2026 Jul 9. PMID- 42437494 OWN - NLM STAT- MEDLINE DCOM- 20260812 LR - 20260909 IS - 1552-8456 (Electronic) IS - 0193-9459 (Linking) VI - 48 IP - 9 DP - 2026 Sep TI - Effects of Low, Moderate, and High Intensity Exercise on Functional Impairment and ADHD Symptoms: A Randomized Pilot Study. PG - 980-987 LID - 10.1177/01939459261458869 [doi] AB - BACKGROUND: Exercise improves cognitive functions impaired in attention deficit/hyperactivity disorder (ADHD); however, most research involves children or animal models. Effects on adult ADHD symptoms and optimal exercise intensity remain unclear. Moderate and high intensity cycling show benefits. PURPOSE: We evaluated the feasibility of an exercise intervention and compared 3 levels of exercise intensity in college students with ADHD symptoms. METHODS: In a randomized controlled trial, 33 participants were assigned to low, moderate, or high intensity exercise. All groups cycled for 20 minutes. The low and moderate intensity groups cycled at low or moderate intensity, respectively. The high intensity group alternated 20-second maximal effort bursts with 120 seconds of low-intensity cycling. The exercise occurred over 1 week. Outcomes were evaluated before and after the intervention. RESULTS: There was a decrease in functional impairment (F = 7.98, P = .009, partial eta(2) = 0.222) and symptom severity (F = 13.43, P = .001, partial eta(2) = 0.324). There was no difference between groups. Inattentive symptoms responded to low intensity (t = 2.62, P = .015, d = 0.874) and moderate intensity exercise (t = 2.61, P = .013, d = 0.786). Impulsive symptoms benefited from low (t = 4.06, P = .002, d = 1.35) and moderate intensity exercise (t = 1.99, P = .037, d = 0.600). Hyperactive symptoms were reduced in the moderate intensity group (t = 2.6, P = .013, d = 0.783). CONCLUSION: Feasibility was demonstrated. Moderate intensity exercise appears to be the most universally effective intensity for reducing ADHD symptoms. STUDY REGISTRATION: ClinicalTrials.gov, NCT06753253. FAU - Edmondson, Meghan E AU - Edmondson ME AUID- ORCID: 0009-0004-0850-2555 AD - College of Nursing, Kent State University, OH, USA. AD - Brain Health Research Institute, Kent State University, OH, USA. AD - Healthy Communities Research Institute, Kent State University, OH, USA. FAU - Ridgel, Angela L AU - Ridgel AL AUID- ORCID: 0000-0001-8517-8710 AD - Brain Health Research Institute, Kent State University, OH, USA. AD - Program of Exercise Science and Exercise Physiology, School of Health Sciences, Kent State University, OH, USA. LA - eng SI - ClinicalTrials.gov/NCT06753253 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260712 PL - United States TA - West J Nurs Res JT - Western journal of nursing research JID - 7905435 SB - IM MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/therapy/psychology MH - Pilot Projects MH - Female MH - Male MH - *Exercise/physiology/psychology MH - *Exercise Therapy/methods/standards MH - Adult OTO - NOTNLM OT - ADHD symptoms OT - attention deficit/hyperactivity disorder OT - exercise OT - intervention OT - physical activity COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/07/12 22:37 MHDA- 2026/08/12 06:05 CRDT- 2026/07/12 13:02 PHST- 2026/08/12 06:05 [medline] PHST- 2026/07/12 22:37 [pubmed] PHST- 2026/07/12 13:02 [entrez] AID - 10.1177/01939459261458869 [doi] PST - ppublish SO - West J Nurs Res. 2026 Sep;48(9):980-987. doi: 10.1177/01939459261458869. Epub 2026 Jul 12. PMID- 42436557 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260911 IS - 1757-2215 (Electronic) IS - 1757-2215 (Linking) VI - 19 IP - 1 DP - 2026 Jul 11 TI - Psychological distress and quality of life in women with infertility due to polycystic ovarian syndrome versus unexplained infertility: a cross-sectional study with phenotype-based analysis. LID - 10.1186/s13048-026-02186-8 [doi] LID - 268 AB - BACKGROUND: Infertility is associated with significant psychological distress and impaired quality of life (QoL) in women. Polycystic Ovarian Syndrome (PCOS), a common cause of infertility, is frequently associated with metabolic and psychological symptoms. However, limited evidence directly compares psychological symptom burden and QoL between women with PCOS-related infertility and unexplained infertility, including across PCOS phenotypes. METHODS: This cross-sectional observational study included 240 women aged 18-40 years with infertility due to PCOS or unexplained causes, conducted at a tertiary care center between October 2019 and March 2021. PCOS was diagnosed using revised Rotterdam criteria, and unexplained infertility was defined after exclusion of known causes. Psychological outcomes were assessed using validated screening instruments (PHQ-9, BDI, BAI, and GAD-7), representing symptom severity rather than clinical psychiatric diagnoses. QoL was assessed using WHOQOL-BREF. Statistical analysis included group comparisons using appropriate parametric and non-parametric tests, with p < 0.05 considered statistically significant. RESULTS: Women with PCOS demonstrated significantly higher screening-based depressive symptom burden (60% vs. 14%, p < 0.001) and anxiety symptom burden (63% vs. 21%, p < 0.001) compared to women with unexplained infertility. QoL scores were significantly lower in the PCOS group (66.8% vs. 85.1%, p < 0.001), particularly in psychological and social domains. Among PCOS phenotypes, hyperandrogenic phenotypes (B and C) showed relatively higher psychological symptom burden and lower QoL scores compared to other phenotypes. The PCOS group also demonstrated higher BMI and androgen levels. CONCLUSION: Infertility associated with PCOS is linked to higher screening-based psychological symptom burden and reduced quality of life compared to unexplained infertility. Hyperandrogenic PCOS phenotypes appear to be more affected. These findings support the integration of routine psychological screening and multidisciplinary support into infertility care for women with PCOS. CI - (c) 2026. The Author(s). FAU - Kataria, Kamna AU - Kataria K AD - Department of Obstetrics & Gynecology, VMMC & Safdarjung Hospital, New Delhi, 110029, India. FAU - Kapoor, Garima AU - Kapoor G AD - Department of Obstetrics & Gynecology, VMMC & Safdarjung Hospital, New Delhi, 110029, India. garimak79@yahoo.co.in. FAU - Saha, Rahul AU - Saha R AD - Department of Psychiatry at VMMC & Safdarjung Hospital, New Delhi, 110029, India. FAU - Lachyan, Abhishek AU - Lachyan A AD - Department of Obstetrics & Gynecology, VMMC & Safdarjung Hospital, New Delhi, 110029, India. LA - eng PT - Journal Article PT - Observational Study DEP - 20260711 PL - England TA - J Ovarian Res JT - Journal of ovarian research JID - 101474849 SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/complications/psychology MH - *Quality of Life/psychology MH - Cross-Sectional Studies MH - Adult MH - *Infertility, Female/psychology/etiology MH - Phenotype MH - Young Adult MH - Adolescent MH - *Psychological Distress PMC - PMC13508219 OTO - NOTNLM OT - Anxiety OT - Depression OT - Infertility OT - PCOS phenotypes OT - Polycystic ovarian syndrome OT - Quality of life COIS- Declarations. Ethics approval and consent to participate: Ethical approval for this study was obtained from the Institutional Ethics Committee of VMMC & Safdarjung Hospital (IEC approval no. IEC/VMMC/SJH/THESIS/2019-10/89; approved on 30 October 2019). The study was conducted in accordance with the principles of the Declaration of Helsinki (2013 revision). Written informed consent was obtained from all participants prior to their inclusion in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/07/12 00:56 MHDA- 2026/08/27 05:35 PMCR- 2026/07/11 CRDT- 2026/07/11 23:38 PHST- 2026/02/24 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/08/27 05:35 [medline] PHST- 2026/07/12 00:56 [pubmed] PHST- 2026/07/11 23:38 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - 10.1186/s13048-026-02186-8 [pii] AID - 2186 [pii] AID - 10.1186/s13048-026-02186-8 [doi] PST - epublish SO - J Ovarian Res. 2026 Jul 11;19(1):268. doi: 10.1186/s13048-026-02186-8. PMID- 42436527 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261009 IS - 1824-7288 (Electronic) IS - 1720-8424 (Linking) VI - 52 IP - 1 DP - 2026 Jul 11 TI - Occurrence of diarrhea in pediatric bronchopneumonia patients: relevance to nursing management. LID - 10.1186/s13052-026-02301-x [doi] LID - 149 AB - BACKGROUND: Diarrhea represents a frequent complication in pediatric patients with bronchopneumonia. This study was designed to identify independent risk factors for diarrheal complications and to propose evidence-informed nursing interventions. METHODS: A retrospective cohort study was conducted among 280 hospitalized children with bronchopneumonia. Demographic, anthropometric, laboratory, and treatment-related data were extracted from electronic medical records. Multicollinearity was assessed by variance inflation factor (VIF), and independent risk factors were identified through binary logistic regression with model fit evaluated by the Hosmer-Lemeshow test. RESULTS: The incidence of diarrhea was 23.57%. Eight independent risk factors were identified: antibiotic duration >/= 7 days (OR = 3.006), beta-lactamase inhibitor combination use (OR = 2.916), combined antibiotic use (OR = 2.401), mixed pulmonary infection (OR = 2.105), age < 5 years (OR = 2.048), weight-for-height/length z-score < - 2 (OR = 1.982), serum albumin < 35 g/L (OR = 1.896), and C-reactive protein >/= 20 mg/L (OR = 1.845). Probiotic administration was an independent protective factor (OR = 0.849). All VIF values were < 5, and the Hosmer-Lemeshow test indicated adequate model fit (P > 0.05). CONCLUSION: Diarrhea in children with bronchopneumonia is associated with multiple clinical and therapeutic variables, with beta-lactamase inhibitor combinations and prolonged antibiotic therapy conferring the highest risk. These findings provide a hypothesis-generating foundation for risk-stratified nursing strategies to reduce diarrheal complications. However, given the retrospective design and the inability to distinguish antibiotic-associated diarrhea from infectious diarrhea, the identified associations should be interpreted cautiously, and any derived clinical recommendations require prospective validation. CI - (c) 2026. The Author(s). FAU - Tang, Yinyan AU - Tang Y AD - Department of pediatrics, Nanjing Lishui People's Hospital, No. 86 Chongwen Road, Lishui District, Nanjing, Jiangsu Province, China. FAU - Zhang, Qian AU - Zhang Q AD - Department of pediatrics, Nanjing Lishui People's Hospital, No. 86 Chongwen Road, Lishui District, Nanjing, Jiangsu Province, China. FAU - Yu, Tingting AU - Yu T AD - Department of pediatrics, Nanjing Lishui People's Hospital, No. 86 Chongwen Road, Lishui District, Nanjing, Jiangsu Province, China. 564440307@qq.com. LA - eng PT - Journal Article DEP - 20260711 PL - England TA - Ital J Pediatr JT - Italian journal of pediatrics JID - 101510759 RN - 0 (Anti-Bacterial Agents) SB - IM MH - Humans MH - Retrospective Studies MH - *Diarrhea/epidemiology/nursing/etiology MH - *Bronchopneumonia/complications/drug therapy/nursing MH - Female MH - Male MH - Risk Factors MH - Child, Preschool MH - Infant MH - Incidence MH - Anti-Bacterial Agents/adverse effects MH - Child PMC - PMC13644138 OTO - NOTNLM OT - Bronchopneumonia OT - Children OT - Clinical OT - Diarrhea OT - Nursing OT - Treatment COIS- Declarations. Ethics approval and consent to participate: In this study, all methods were performed in accordance with the relevant guidelines and regulations. The study has been reviewed and approved by the ethics committee of Nanjing Lishui People's Hospital (Ethics Approval No.: 2025KY0922-02). Although written informed consent from the children's guardians was not separately obtained due to the retrospective nature of the study, the Ethics Committee has verified that: the research data are non-identifiable information generated during routine clinical diagnosis and treatment; the study results can be used to clarify the influencing factors of bronchopneumonia complicated with diarrhea in children and optimize clinical nursing protocols, ultimately providing evidence-based support for reducing the incidence of pneumonia-related complications in children and improving their prognosis. The public health value and potential benefits of the study are significantly greater than the risks, which is in line with the ethical principle of "reasonable risk-benefit ratio". Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/07/12 04:10 MHDA- 2026/10/07 05:31 PMCR- 2026/07/11 CRDT- 2026/07/11 23:37 PHST- 2026/04/04 00:00 [received] PHST- 2026/06/20 00:00 [accepted] PHST- 2026/10/07 05:31 [medline] PHST- 2026/07/12 04:10 [pubmed] PHST- 2026/07/11 23:37 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - 10.1186/s13052-026-02301-x [pii] AID - 2301 [pii] AID - 10.1186/s13052-026-02301-x [doi] PST - epublish SO - Ital J Pediatr. 2026 Jul 11;52(1):149. doi: 10.1186/s13052-026-02301-x. PMID- 42436490 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261002 IS - 1472-6963 (Electronic) IS - 1472-6963 (Linking) VI - 26 IP - 1 DP - 2026 Jul 11 TI - Assessment of maternal healthcare utilization and continuum of care among reproductive-age women in Gujarat: a cross-sectional study. LID - 10.1186/s12913-026-15063-3 [doi] LID - 1325 AB - BACKGROUND: A healthcare system's efficacy is demonstrated by safe motherhood, which is an essential aspect of women's health. Preconception, pregnancy, labor, and the postoperative phase are all included in this continuum of care. There are still gaps in maternal healthcare awareness, use, and continuity, especially during preconception and the early postnatal stages, even though India has made great strides in lowering maternal mortality through national health programs and better access to institutional deliveries and antenatal care. The purpose of this study was to evaluate Gujarati women's knowledge, availability, and use of maternal health services, with an emphasis on preconception care, prenatal care, delivery procedures, and postnatal follow-up. METHODOLOGY: The study used a descriptive cross-sectional methodology and included 318 reproductive-age women from semi-urban, urban, and rural areas using a structured pre-validated questionnaire. Both quantitative information about maternal health practices and experiences were gathered through in-person interviews and Google Forms and analyzed using descriptive statistics including frequencies and percentages in Microsoft Excel. RESULTS: Among the 318 respondents, 75.5% were aged 18-30 years and 50% resided in rural areas. Awareness regarding preconception health checkups was reported by 71.1% of women, whereas 28.9% lacked such awareness. Antenatal care utilization was high, with 87.1% attending antenatal checkups, the majority receiving tetanus toxoid immunization and iron-folic acid supplementation, and 97.3% undergoing institutional deliveries with skilled birth assistance. However, only 58.2% of women received postnatal care within 48 hours after delivery. Nutritional counseling was reported by 41% of respondents, while 55.2% received breastfeeding counseling. Significant gaps were found in preconception health information, early postnatal follow-up, and emotional support, especially among rural women. CONCLUSION: The study highlights the need to shift focus from service availability to continuity and quality of maternal care. Strengthening preconception education, ensuring timely postnatal follow-up through community health workers, expanding counseling services, and promoting family engagement are essential to improving maternal and neonatal health outcomes. CI - (c) 2026. The Author(s). FAU - Avhad, Ujwala AU - Avhad U AD - Parul Institute of Public Health, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. FAU - Gohel, Swati AU - Gohel S AD - Parul Institute of Public Health, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. FAU - Sompura, Parth AU - Sompura P AD - Parul Institute of Allied & Healthcare Sciences, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. FAU - Sompura, Krishna AU - Sompura K AUID- ORCID: 0000-0003-1202-1485 AD - Faculty of Pharmacy, Parul Institute of Pharmacy, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. krishna.sompura26855@paruluniversity.ac.in. FAU - Kshatriya, Pranav AU - Kshatriya P AD - Parul Institute of Public Health, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. FAU - Rohit, Kaushal AU - Rohit K AD - Parul Institute of Public Health, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. FAU - Modi, Ekta AU - Modi E AD - Parul Sevashram Hospital, Waghodia, Vadodara, Gujarat, 391760, India. FAU - Ganguly, Parthasarathi AU - Ganguly P AD - Parul Institute of Public Health, Parul University, Waghodia, Vadodara, Gujarat, 391760, India. LA - eng PT - Journal Article DEP - 20260711 PL - England TA - BMC Health Serv Res JT - BMC health services research JID - 101088677 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - India MH - *Continuity of Patient Care/statistics & numerical data MH - Adult MH - *Maternal Health Services/statistics & numerical data MH - Adolescent MH - Pregnancy MH - Young Adult MH - *Health Knowledge, Attitudes, Practice MH - Prenatal Care/statistics & numerical data MH - Surveys and Questionnaires PMC - PMC13625414 OTO - NOTNLM OT - Antenatal and postnatal care OT - Family support OT - Gujarat OT - Maternal health OT - Preconception health OT - Safe motherhood COIS- Declarations. Ethics approval and consent to participate: Parul University - Institutional Ethics Committee approval on Human Research no. ECR/702/Inst/GJ/2015/RR-21/10206. All procedures involving human participants/data were conducted in accordance with institutional ethical standards and the Declaration of Helsinki. Ethical approval was obtained from the Institutional Ethics Committee, and informed consent was obtained from all participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/12 00:54 MHDA- 2026/09/30 05:30 PMCR- 2026/07/11 CRDT- 2026/07/11 23:36 PHST- 2026/04/20 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/09/30 05:30 [medline] PHST- 2026/07/12 00:54 [pubmed] PHST- 2026/07/11 23:36 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - 10.1186/s12913-026-15063-3 [pii] AID - 15063 [pii] AID - 10.1186/s12913-026-15063-3 [doi] PST - epublish SO - BMC Health Serv Res. 2026 Jul 11;26(1):1325. doi: 10.1186/s12913-026-15063-3. PMID- 42436436 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261009 IS - 1472-6920 (Electronic) IS - 1472-6920 (Linking) VI - 26 IP - 1 DP - 2026 Jul 11 TI - Refeeding syndrome knowledge among healthcare providers in a tertiary care pediatric center: a pre- and post-effective education & awareness test analysis. LID - 10.1186/s12909-026-09812-5 [doi] LID - 1588 AB - BACKGROUND: Refeeding syndrome (RFS) is a potentially fatal condition with reported pediatric intensive care incidence rates up to 7.4%. Despite heightened vulnerability in children due to higher metabolic rates, substantial knowledge deficits persist among pediatric healthcare providers regarding RFS recognition and management, creating critical patient safety risks. OBJECTIVE: To evaluate the effectiveness of a comprehensive multimodal educational intervention in improving refeeding syndrome knowledge among pediatric healthcare providers in a tertiary care setting. METHODS: A prospective pre-post interventional study was conducted from November 2024 to May 2025. Following baseline knowledge assessment using a validated 16-item questionnaire, participants received a 6-month structured educational intervention comprising lectures, evidence-based guidelines, multimedia resources, and reinforcement activities. Post-intervention assessment evaluated knowledge improvement across fundamental understanding and clinical management domains. RESULTS: Sixty-nine participants completed baseline assessment, with 62 completing follow-up (89.9% retention). Significant improvements occurred across all domains: comprehensive RFS definition recognition (58.5% to 83.9%, p = 0.002), metabolic disturbance understanding (60.3% to 87.3%, p = 0.0006), timing recognition (44.6% to 77.4%, p = 0.002), risk stratification (43.5% to 71.0%, p = 0.001), electrolyte monitoring protocols (39.1% to 74.2%, p < 0.001), and clinical scenario management (43.5% to 79.0%, p < 0.001). Excellent fundamental knowledge performance increased from 47.8% to 79.0%, while poor performance decreased from 18.8% to 3.2% (p < 0.001). Fellows and senior residents demonstrated greater improvement than junior residents, suggesting experience-dependent educational responsiveness. CONCLUSIONS: Structured multimodal educational interventions produce substantial, clinically meaningful improvements in pediatric RFS knowledge across all competency domains. These findings support implementing systematic RFS education programs in pediatric institutions to enhance patient safety, with particular attention to experience-appropriate content delivery for optimal educational effectiveness. CI - (c) 2026. The Author(s). FAU - AlKateb, Faten Ahmad AU - AlKateb FA AUID- ORCID: 0000-0002-8672-6034 AD - Department of General Paediatrics, King Fahad Medical City, Riyadh, Saudi Arabia. fatenmil@yahoo.com. FAU - Alanazy, Nora Khalid AU - Alanazy NK AD - Department of General Paediatrics, King Fahad Medical City, Riyadh, Saudi Arabia. FAU - Basakran, Asma Fayez AU - Basakran AF AD - Department of General Paediatrics, King Fahad Medical City, Riyadh, Saudi Arabia. Asma.baskran@gmail.com. FAU - Mehmadi, Sameer AU - Mehmadi S AD - Department of Paediatric Neurology, King Faisal Specialized Hospital, Riyadh, Saudi Arabia. LA - eng GR - 025-008/King Fahd Medical City/ PT - Journal Article DEP - 20260711 PL - England TA - BMC Med Educ JT - BMC medical education JID - 101088679 SB - IM MH - Humans MH - Prospective Studies MH - *Refeeding Syndrome/therapy/diagnosis MH - Tertiary Care Centers MH - Female MH - *Health Knowledge, Attitudes, Practice MH - *Health Personnel/education MH - *Clinical Competence MH - Male MH - Pediatrics/education MH - Educational Measurement MH - Surveys and Questionnaires MH - Child PMC - PMC13644186 OTO - NOTNLM OT - Educational intervention OT - Healthcare providers OT - Knowledge assessment OT - Patient safety OT - Pediatric care OT - Refeeding syndrome COIS- Declarations. Ethics approval and consent to participate: This study was approved by the institutional review board of King Fahad Medical City, Riyadh, Saudi Arabia (Approval No. 24-410). The study was conducted in accordance with the ethical principles of the Declaration of Helsinki. Written informed consent was obtained from all participants. Consent for publication: all authors have given consent for publication. Competing interests: The authors declare no competing interests. EDAT- 2026/07/12 00:54 MHDA- 2026/10/07 05:31 PMCR- 2026/07/11 CRDT- 2026/07/11 23:35 PHST- 2025/07/29 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/10/07 05:31 [medline] PHST- 2026/07/12 00:54 [pubmed] PHST- 2026/07/11 23:35 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - 10.1186/s12909-026-09812-5 [pii] AID - 9812 [pii] AID - 10.1186/s12909-026-09812-5 [doi] PST - epublish SO - BMC Med Educ. 2026 Jul 11;26(1):1588. doi: 10.1186/s12909-026-09812-5. PMID- 42436401 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261010 IS - 1471-2342 (Electronic) IS - 1471-2342 (Linking) VI - 26 IP - 1 DP - 2026 Jul 11 TI - Linking vertebral trabecular structure to growth rate: clinical and developmental insights. LID - 10.1186/s12880-026-02583-x [doi] LID - 507 AB - OBJECTIVES: To evaluate the effectiveness of chronological age (CA), sex, and fractal dimension (FD) values in classifying skeletal maturation stages using multinomial logistic regression analysis. MATERIALS AND METHODS: Lateral cephalometric radiographs and hand-wrist radiographs (HWRs) of 923 individuals (409 boys and 514 girls) aged 7-18 years were analyzed. Nine regions of interest located in the C2, C3, and C4 vertebral bodies were selected for the fractal analysis. Skeletal maturation stages were determined using Fishman's skeletal maturity indicator (SMI) method and categorized into accelerating (n = 201; 141 boys and 60 girls), high (n = 334; 165 boys and 169 girls), and decreasing (n = 388; 103 boys and 285 girls) growth velocity groups. Multinomial logistic regression was used to evaluate the associations of CA, sex, and FD values with maturation group membership. Relative risk ratios (RRRs) and 95% confidence intervals (CIs) were calculated to assess the effects of CA, sex, and FD values on maturation stage classification. RESULTS: The full model was statistically significant compared with the intercept-only model and achieved an overall apparent classification accuracy of 77.8%. The age-and-sex-only model had a Nagelkerke R(2) of 0.768 and an accuracy of 77.2%, whereas the full model including FD variables had a Nagelkerke R(2) of 0.779 and an accuracy of 77.8%. These results indicate that FD measurements provided a modest additional contribution beyond CA and sex. CA and sex were the most stable predictors. Among FD variables, C2 anterior FD showed a significant overall effect, while C4 medial and C4 posterior FD showed more limited, category-specific associations. CONCLUSION: CA and sex were the primary predictors of maturation group membership. FD values from selected cervical vertebral regions may provide supplementary information, but their contribution was modest and should be interpreted cautiously until externally validated. CLINICAL RELEVANCE: Cervical vertebral fractal analysis may provide supplementary information for skeletal maturation assessment when combined with chronological age and sex; however, external validation is required. CI - (c) 2026. The Author(s). FAU - Gonca, Merve AU - Gonca M AD - Faculty of Dentistry, Department of Orthodontics, Eskisehir Osmangazi University, Eskisehir, Turkiye. FAU - Sert, Mehmet Fatih AU - Sert MF AD - Department of Business Administration (Quantitative Methods), Gaziantep University, Gaziantep, Turkiye. FAU - Gunacar, Dilara Nil AU - Gunacar DN AD - Faculty of Dentistry, Department of Oral and Dentomaxillofacial Radiology, Recep Tayyip Erdogan University, Rize, Turkiye. FAU - Kose, Taha Emre AU - Kose TE AD - Faculty of Dentistry, Department of Oral and Dentomaxillofacial Radiology, Recep Tayyip Erdogan University, Rize, Turkiye. FAU - Beser Gul, Busra AU - Beser Gul B AD - Faculty of Dentistry, Department of Orthodontics, Recep Tayyip Erdogan University, Rize, Turkey. busra.beser@erdogan.edu.tr. FAU - Uygun, Samet AU - Uygun S AD - Faculty of Dentistry, Department of Orthodontics, Recep Tayyip Erdogan University, Rize, Turkey. LA - eng PT - Journal Article DEP - 20260711 PL - England TA - BMC Med Imaging JT - BMC medical imaging JID - 100968553 SB - IM MH - Humans MH - Female MH - Child MH - Male MH - Adolescent MH - *Age Determination by Skeleton/methods MH - Cephalometry MH - Fractals MH - *Cervical Vertebrae/growth & development/diagnostic imaging MH - Logistic Models MH - Sex Factors MH - *Cancellous Bone/diagnostic imaging/growth & development PMC - PMC13647740 OTO - NOTNLM OT - Algorithms OT - Fractals OT - Growth and development OT - Machine learning OT - Orthodontics OT - Vertebrae COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical principles of the Declaration of Helsinki and its subsequent amendments. The Institutional Review Board and Clinical Ethics Committee of Recep Tayyip Erdogan University Medicine Faculty approved this retrospective clinical study (decision date and number: 24.04.2024/78). For participants under 16 years of age, detailed information about this research was provided to their parents or legal guardians before the study, and an informed consent form was obtained. For participants aged 16 and older, informed consent was obtained directly from the individuals themselves. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/12 04:10 MHDA- 2026/10/08 05:31 PMCR- 2026/07/11 CRDT- 2026/07/11 23:34 PHST- 2026/03/16 00:00 [received] PHST- 2026/07/08 00:00 [accepted] PHST- 2026/10/08 05:31 [medline] PHST- 2026/07/12 04:10 [pubmed] PHST- 2026/07/11 23:34 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - 10.1186/s12880-026-02583-x [pii] AID - 2583 [pii] AID - 10.1186/s12880-026-02583-x [doi] PST - epublish SO - BMC Med Imaging. 2026 Jul 11;26(1):507. doi: 10.1186/s12880-026-02583-x. PMID- 42436365 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1471-2180 (Electronic) IS - 1471-2180 (Linking) VI - 26 IP - 1 DP - 2026 Jul 11 TI - Clinical presentation and detection of SARS-CoV-2, influenza-A/B among patients with upper respiratory tract infections in a tertiary hospital in Pune: a pilot study. LID - 10.1186/s12866-026-05307-x [doi] LID - 630 AB - BACKGROUND: Acute respiratory illness (ARI) is one of the most common illnesses globally, affecting all age groups and leading to both upper respiratory tract infections (URTIs) and lower respiratory tract infections (LRTIs). Viral pathogens such as influenza viruses and SARS-CoV-2 are major contributors to upper respiratory tract infections and continue to pose significant clinical and public health challenges. AIM: This study aimed to compare the clinical presentation and haematological profiles of adult patients with rRT-PCR-confirmed SARS-CoV-2, Influenza A, Influenza B, and virus-negative URTIs presenting to a tertiary-care hospital in Pune. MATERIALS AND METHODS: Nasopharyngeal swab samples collected from 123 adult patients presenting with URTI between March and November 2023 were tested at the ICMR-National Institute of Virology (NIV), Pune, using multiplex real-time reverse transcription polymerase chain reaction (rRT-PCR) assays for detection of SARS-CoV-2, Influenza A/B, and other respiratory viral pathogens. RNA extraction was performed using a Zybio kit, and a multiplex single-tube combo rRT-PCR assay. RESULTS: The study examined 123 individuals with upper respiratory tract infections (URTIs), 12 of whom had influenza A, 8 of whom had influenza B, and 6 of whom had SARS-CoV-2. No significant differences were observed in age, anthropometric parameters, vital signs, or comorbidity distribution across groups. Significant intergroup differences were identified in cough, sputum production, vomiting/nausea, and nasal discharge/stuffiness (all p < 0.05). Haematological analysis demonstrated significant variations in total WBC count, lymphocyte, monocyte, and neutrophil percentages. Significant intergroup differences were also observed for NLR (p = 0.0013) and PLR (p = 0.0134). CONCLUSION: This pilot study identified differences in selected symptom profiles and haematological parameters and derived inflammatory indices among patients with SARS-CoV-2, Influenza A, Influenza B, and virus-negative URTIs. These findings may contribute to a better understanding of respiratory infection patterns in clinical settings; however, larger studies are required to validate their diagnostic and clinical significance. CI - (c) 2026. The Author(s). FAU - Jali, Priyanka AU - Jali P AD - Central Research Facility, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr D.Y. Patil Vidyapeeth, (Deemed to be University), Sant Tukaram Nagar, Pimpri, Pune, 411018, India. FAU - Potdar, Varsha AU - Potdar V AD - Scientist 'E' and Influenza Group, ICMR-National Institute of Virology, Ambedkar Road, Pune, India. FAU - Pardeshi, Anil AU - Pardeshi A AD - Global Research Cell, Dr. D. Y. Patil Dental College and Hospital, Pimpri Dr. D. Y. Patil Vidyapeeth (deemed to be University), Pune, 411018, India. anil.pardeshi@dpu.edu.in. FAU - Suryawanshi, Poonam AU - Suryawanshi P AD - Central Research Facility, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr D.Y. Patil Vidyapeeth, (Deemed to be University), Sant Tukaram Nagar, Pimpri, Pune, 411018, India. FAU - Gandhi, Madhura AU - Gandhi M AD - Central Research Facility, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr D.Y. Patil Vidyapeeth, (Deemed to be University), Sant Tukaram Nagar, Pimpri, Pune, 411018, India. FAU - Sarawade, Shrishail AU - Sarawade S AD - Central Research Facility, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr D.Y. Patil Vidyapeeth, (Deemed to be University), Sant Tukaram Nagar, Pimpri, Pune, 411018, India. FAU - Kanitkar, Shubhangi AU - Kanitkar S AD - Department of General Medicine, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, (Deemed to be University), Pimpri, Pune, India. FAU - Vikhe, Vikram AU - Vikhe V AD - Department of General Medicine, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, (Deemed to be University), Pimpri, Pune, India. FAU - Barthwal, Madhusudan AU - Barthwal M AD - Department of Respiratory Medicine, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, (Deemed to be University), Pimpri, Pune, India. FAU - Dole, Sachin AU - Dole S AD - Department of Respiratory Medicine, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr. D.Y. Patil Vidyapeeth, (Deemed to be University), Pimpri, Pune, India. FAU - Chavan, Hanumant AU - Chavan H AD - Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr D.Y. Patil Vidyapeeth, (Deemed to be University), Pimpri, Pune, India. FAU - Parag, Ratnakar AU - Parag R AD - Central Clinical Laboratory, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr D.Y. Patil Vidyapeeth, (Deemed to be University), Pimpri, Pune, India. FAU - Bhattad, Divya AU - Bhattad D AD - ICMR-National Institute of Virology, Camp, Next to Marathi Church, Ambedkar Road, Post Box No. 11, Pune, 411001, India. FAU - Jadhav, Sheetal AU - Jadhav S AD - ICMR-National Institute of Virology, Camp, Next to Marathi Church, Ambedkar Road, Post Box No. 11, Pune, 411001, India. FAU - Vipat, Veena AU - Vipat V AD - ICMR-National Institute of Virology, Camp, Next to Marathi Church, Ambedkar Road, Post Box No. 11, Pune, 411001, India. FAU - Tripathy, Srikanth AU - Tripathy S AD - Central Research Facility, Dr D.Y. Patil Medical College, Hospital and Research Centre, Dr D.Y. Patil Vidyapeeth, (Deemed to be University), Sant Tukaram Nagar, Pimpri, Pune, 411018, India. srikanthtripathy@gmail.com. LA - eng PT - Journal Article DEP - 20260711 PL - England TA - BMC Microbiol JT - BMC microbiology JID - 100966981 SB - IM MH - Humans MH - Pilot Projects MH - Female MH - Tertiary Care Centers MH - Male MH - *Respiratory Tract Infections/virology/diagnosis/epidemiology MH - Middle Aged MH - Adult MH - *SARS-CoV-2/isolation & purification/genetics MH - *Influenza, Human/diagnosis/virology/epidemiology MH - *Influenza B virus/isolation & purification/genetics MH - India/epidemiology MH - *Influenza A virus/isolation & purification/genetics MH - *COVID-19/diagnosis/epidemiology/virology MH - Aged MH - Young Adult MH - Nasopharynx/virology MH - Adolescent PMC - PMC13374207 OTO - NOTNLM OT - Acute respiratory illness (ARI) OT - Haematological parameters OT - Influenza OT - SARS-CoV-2 OT - Upper respiratory tract infections (URTIs) OT - rRT-PCR COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with institutional and national ethical guidelines and in compliance with the principles of the Declaration of Helsinki. Prior to study initiation, ethical approval was obtained from the Institutional Ethics Committee of ICMR-National Institute of Virology, Pune (IEC Approval No: NIV-IEC/Oct/2021/D-5). Written informed consent was obtained from all participants before enrolment in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/12 00:54 MHDA- 2026/07/17 12:41 PMCR- 2026/07/11 CRDT- 2026/07/11 23:33 PHST- 2026/03/31 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/07/17 12:41 [medline] PHST- 2026/07/12 00:54 [pubmed] PHST- 2026/07/11 23:33 [entrez] PHST- 2026/07/11 00:00 [pmc-release] AID - 10.1186/s12866-026-05307-x [pii] AID - 5307 [pii] AID - 10.1186/s12866-026-05307-x [doi] PST - epublish SO - BMC Microbiol. 2026 Jul 11;26(1):630. doi: 10.1186/s12866-026-05307-x. PMID- 42434646 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260711 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 6 DP - 2026 Jun TI - Accuracy Assessment of a Wrist-Worn Oscillometric Blood Pressure Device Applied to the Upper Arm in Children. PG - e110605 LID - 10.7759/cureus.110605 [doi] LID - e110605 AB - Background Accurate blood pressure (BP) measurement in children is essential for detecting pediatric hypertension, yet validation evidence for wrist-worn oscillometric devices in this population is sparse. The nonstandard application of a wrist BP device to the upper arm, a clinically plausible scenario when cuff size is compatible with a child's arm circumference, has not been previously evaluated. This study aimed to evaluate the accuracy and validation of a wrist-worn oscillometric BP device applied to the upper arm in children aged 3-8.5 years using brachial auscultatory mercury sphygmomanometry as the reference standard. Methodology This prospective, cross-sectional validation study enrolled 100 children (58 males; mean age = 4.9 +/- 1.5 years) in a tertiary care hospital. A wrist-worn oscillometric device was applied to the upper arm and compared with brachial auscultatory mercury sphygmomanometry using the International Organization for Standardization (ISO) 81060-2:2018. A same-arm sequential protocol was used, yielding 300 paired comparisons. Accuracy was assessed using ISO Criteria 1 and 2, the British Hypertension Society (BHS) grading, and Bland-Altman analysis. Additionally, proportional bias regression and subgroup analyses were performed. Results The device met both ISO criteria for systolic BP (SBP; mean error = -4.62 +/- 6.02 mmHg) and diastolic BP (DBP; -2.70 +/- 5.19 mmHg). BHS grading was Grade A for DBP and Grade B for SBP. Bland-Altman 95% limits of agreement were -16.41 to +7.17 mmHg (SBP) and -12.88 to +7.48 mmHg (DBP). Significant proportional bias was observed for SBP (r = 0.370, p < 0.001) and DBP (r = 0.153, p = 0.008) with increasing underestimation at higher BP values. No sex differences were identified; a statistically significant but small age group difference was observed for DBP only. Conclusions This wrist-worn device applied to the upper arm met ISO validation requirements in 3-8.5-year-old children, and achieved BHS Grade A for DBP and Grade B for SBP. This device may be used as a screening tool in children of the tested age range, with confirmatory brachial auscultation recommended for elevated readings. The predominantly normotensive BP distribution in this cohort limits generalization of performance to hypertensive pediatric populations. Future studies should confirm our findings, recruit broader BP distributions, assess diverse anthropometrics, evaluate movement sensitivity, and explore pediatric-specific algorithms to reduce SBP proportional bias. CI - Copyright (c) 2026, Mahapatra et al. FAU - Mahapatra, Akankshya AU - Mahapatra A AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. FAU - Siddiqui, Mohd Saeed AU - Siddiqui MS AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. FAU - Haseeb, Mohammad AU - Haseeb M AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. FAU - Sangle, Avinash L AU - Sangle AL AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. FAU - Ingale, Vinod AU - Ingale V AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. FAU - Joshi, Pradnya M AU - Joshi PM AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. FAU - Supe, Prajakta AU - Supe P AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. FAU - Sachdev, Siddhant AU - Sachdev S AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. FAU - Shaikh, Rabiah AU - Shaikh R AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. FAU - Mohapatra, Abinash AU - Mohapatra A AD - Pediatrics, Mahatma Gandhi Mission Medical College and Hospital, Mahatma Gandhi Mission Institute of Health Sciences, Aurangabad, IND. LA - eng PT - Journal Article DEP - 20260610 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13353792 OTO - NOTNLM OT - blood pressure (bp) OT - british hypertension society OT - children OT - iso 81060-2 OT - oscillometric OT - validation OT - wrist device COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Mahatma Gandhi Mission Ethics Committee for Research on Human Subjects issued approval MGM-ECRHS/2024/120. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/07/11 06:36 MHDA- 2026/07/11 06:37 PMCR- 2026/06/10 CRDT- 2026/07/11 05:19 PHST- 2026/06/10 00:00 [accepted] PHST- 2026/07/11 06:37 [medline] PHST- 2026/07/11 06:36 [pubmed] PHST- 2026/07/11 05:19 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.7759/cureus.110605 [doi] PST - epublish SO - Cureus. 2026 Jun 10;18(6):e110605. doi: 10.7759/cureus.110605. eCollection 2026 Jun. PMID- 42434097 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260711 LR - 20260813 IS - 2008-7802 (Print) IS - 2008-8213 (Electronic) IS - 2008-7802 (Linking) VI - 17 DP - 2026 TI - Television (TV) Food Commercials Target Children: A Content Analysis of TV Food Advertisements in Iran. PG - 40 LID - 10.4103/ijpvm.ijpvm_274_24 [doi] LID - 40 AB - BACKGROUND: This study aimed to analyze the content of Iran's television (TV) food advertisements directed at children in 2020. METHODS: All the programs broadcast on Channel II TV were downloaded for one week; however, only children's programs were analyzed. The validated protocol was used to analyze the content of the advertisements. In addition, compliance of food advertisements with Iran's, World Health Organization Eastern Mediterranean Region (WHO EMR), and International Network for Food and Obesity/Non-communicable Diseases (NCDs) Research Monitoring and Action Support (INFORMAS) standards was assessed. RESULTS: A total of 761 TV advertisements targeted children on channel II. "Food products" were the most frequent advertisements (41.7%). "Desserts and sweets" were the most advertised food products (46%), followed by "condiments" and "dairy products" (20.5% and 11.7%, respectively). "Stimulation of appetite" and "high quality/careful preparation" were the most frequent appeals for advertisements directed at children. "Animation/Company-owned character(s)" was the most frequent advertising strategy. Most food advertisements adhered to Iran's regulations; however, according to the WHO EMR and INFORMAS, most food advertisements have not met advertising standards. Present research revealed that food products were a prominent part of other advertisements on children's TV. CONCLUSIONS: Children were predominantly exposed to foods high in fat, salt, and sugar, and the share of unhealthy food advertisements, such as desserts, sweets, fast foods, fats, and sugared drinks, was significant. Regarding the high violation rate of the advertising regulations, a more careful audit of commercials targeting children is highly recommended. CI - Copyright: (c) 2026 International Journal of Preventive Medicine. FAU - Amini, Maryam AU - Amini M AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Shafaatdoost, Mehrnoosh AU - Shafaatdoost M AD - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetic, Tehran University of Medical Sciences, Tehran, Iran. FAU - Ghodsi, Delaram AU - Ghodsi D AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Borazjani, Mohadese AU - Borazjani M AD - Department of Community Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Aghayan, Maryam AU - Aghayan M AD - Department of Community Nutrition, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Shariatzadeh, Nastaran AU - Shariatzadeh N AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition Sciences and Food Technology, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article DEP - 20260529 PL - Iran TA - Int J Prev Med JT - International journal of preventive medicine JID - 101535380 PMC - PMC13354310 OTO - NOTNLM OT - Advertisement OT - children OT - food OT - regulation OT - violation COIS- The authors declare that they have no competing interests. EDAT- 2026/07/11 06:37 MHDA- 2026/07/11 06:38 PMCR- 2026/05/29 CRDT- 2026/07/11 05:13 PHST- 2024/09/07 00:00 [received] PHST- 2026/01/29 00:00 [accepted] PHST- 2026/07/11 06:38 [medline] PHST- 2026/07/11 06:37 [pubmed] PHST- 2026/07/11 05:13 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - IJPVM-17-40 [pii] AID - 10.4103/ijpvm.ijpvm_274_24 [doi] PST - epublish SO - Int J Prev Med. 2026 May 29;17:40. doi: 10.4103/ijpvm.ijpvm_274_24. eCollection 2026. PMID- 42433989 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260711 LR - 20260813 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 13 DP - 2026 TI - The health benefits of alkaline water: is it a fact or marketing myth? PG - 1849818 LID - 10.3389/fmed.2026.1849818 [doi] LID - 1849818 AB - BACKGROUND: Alkaline water has gained widespread popularity and is frequently marketed for benefits related to hydration, acid-base balance, metabolic health, and immune function. These claims are increasingly encountered in primary care, yet their clinical validity remains uncertain. OBJECTIVE: To critically evaluate current evidence on alkaline water, focusing on its physiological effects, clinical relevance, and safety in routine patient care. METHODS: A narrative review of the literature was conducted, including human clinical studies, experimental interventions, and animal models. Outcomes examined included gastrointestinal health, hydration status, bone metabolism, metabolic parameters, oxidative stress, and immune function. RESULTS: Evidence suggests that alkaline water provides limited, context-specific benefits. The most consistent findings relate to gastrointestinal effects, particularly pepsin inactivation and potential improvement in reflux-related symptoms. Modest effects on hydration markers, urinary pH, and selected indicators of bone resorption have been reported, especially with bicarbonate-rich formulations. In contrast, evidence supporting metabolic, antioxidant, and immunological benefits is inconsistent and largely derived from small or preclinical studies. Claims of systemic alkalinization, enhanced immunity, anti-aging, and disease prevention are not supported by robust clinical evidence. CLINICAL IMPLICATIONS: Alkaline water should not be routinely recommended in primary care. Clinicians should emphasize evidence-based interventions and exercise caution in vulnerable populations, including individuals with chronic kidney disease, those on acid-suppressive therapy, pregnant women, and children. CONCLUSION: Alkaline water has limited clinical utility. Its effects are modest and likely driven more by mineral composition than pH alone. Further well-designed, long-term studies are required before definitive recommendations can be made. CI - Copyright (c) 2026 Alebrahim, Alsaei, Sefen, Hasan, Ramadhan and Deen. FAU - Alebrahim, Hassan AU - Alebrahim H AD - Materials for Medicine Research Group, School of Medicine, Royal College of Surgeons in Ireland (RCSI), Medical University of Bahrain, Busaiteen, Bahrain. FAU - Alsaei, Adnan AU - Alsaei A AD - Materials for Medicine Research Group, School of Medicine, Royal College of Surgeons in Ireland (RCSI), Medical University of Bahrain, Busaiteen, Bahrain. FAU - Sefen, Peter AU - Sefen P AD - Materials for Medicine Research Group, School of Medicine, Royal College of Surgeons in Ireland (RCSI), Medical University of Bahrain, Busaiteen, Bahrain. FAU - Hasan, Mohammed AU - Hasan M AD - Materials for Medicine Research Group, School of Medicine, Royal College of Surgeons in Ireland (RCSI), Medical University of Bahrain, Busaiteen, Bahrain. FAU - Ramadhan, Abdulmuhsen AU - Ramadhan A AD - Materials for Medicine Research Group, School of Medicine, Royal College of Surgeons in Ireland (RCSI), Medical University of Bahrain, Busaiteen, Bahrain. FAU - Deen, G Roshan AU - Deen GR AD - Materials for Medicine Research Group, School of Medicine, Royal College of Surgeons in Ireland (RCSI), Medical University of Bahrain, Busaiteen, Bahrain. LA - eng PT - Journal Article PT - Review DEP - 20260626 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC13352663 OTO - NOTNLM OT - alkaline water OT - bone health OT - diabetes OT - gastro intestinal OT - health benefits OT - myth or fact COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/11 13:10 MHDA- 2026/07/11 13:11 PMCR- 2026/06/26 CRDT- 2026/07/11 05:11 PHST- 2026/04/07 00:00 [received] PHST- 2026/06/04 00:00 [revised] PHST- 2026/06/05 00:00 [accepted] PHST- 2026/07/11 13:11 [medline] PHST- 2026/07/11 13:10 [pubmed] PHST- 2026/07/11 05:11 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 10.3389/fmed.2026.1849818 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Jun 26;13:1849818. doi: 10.3389/fmed.2026.1849818. eCollection 2026. PMID- 42433965 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260711 LR - 20260813 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 6 DP - 2026 Jun 30 TI - Development and external validation of machine learning models to predict insulin resistance among iron-deficient children and adolescents. PG - 231 LID - 10.21037/tp-2026-1-0146 [doi] LID - 231 AB - BACKGROUND: Insulin resistance (IR) represents a critical metabolic complication in iron-deficient children, yet existing predictive models target general or overweight pediatric populations and do not account for iron-deficiency as a distinct risk modifier. This study aimed to develop and externally validate machine learning (ML) models using routinely available clinical parameters to address this diagnostic gap. METHODS: We utilized data from 222 iron-deficient children and adolescents aged 6 to 17 years from the China Health and Nutrition Survey (CHNS) for model training, and 125 cases from two hospitals for external validation. Iron-deficiency was defined using age- and sex-specific soluble transferrin receptor (sTfR) thresholds, with exclusion of elevated high-sensitivity C-reactive protein (hs-CRP) (>/=5 mg/L) or missing metabolic variables. IR was defined as Homeostatic Model Assessment for Insulin Resistance (HOMA IR) exceeding 3.0. Least Absolute Shrinkage and Selection Operator (LASSO) regression selected nine predictors from 27 candidate variables (demographics, anthropometrics, blood pressure, hematology, glucose metabolism, lipids, hepatic and renal function). Four ML algorithms [logistic regression (LR), random forest (RF), k-nearest neighbor (KNN), and extreme gradient boosting (XGBoost)] were developed and evaluated by area under the curve, sensitivity, specificity, and calibration, with five-fold repeated cross-validation for internal validation. SHapley Additive exPlanations (SHAP) analysis quantified predictor contributions. RESULTS: XGBoost achieved optimal discriminative performance with an external validation area under the receiver operating characteristic curve (AUC) of 0.940 [95% confidence interval (CI): 0.889-0.991], outperforming other algorithms. RF demonstrated the highest training AUC (0.993, 95% CI: 0.987-1.000) with near-perfect sensitivity (0.985, 95% CI: 0.920-1.000) but showed limited generalization capacity given minimal training-validation divergence. LR and KNN achieved lower validation AUC values of 0.832 (95% CI: 0.743-0.922) and 0.823 (95% CI: 0.740-0.905), respectively. XGBoost was selected as the final model based on superior specificity (0.967, 95% CI: 0.906-0.993) and tighter CIs, indicating more stable performance estimation. Fasting glucose (mean |SHAP| =0.707) and triglycerides (0.383) emerged as dominant predictors, while albumin demonstrated a protective association [odds ratio (OR) 0.86, 95% CI: 0.78-0.95]. CONCLUSIONS: This study establishes an externally validated, interpretable ML framework for predicting IR among iron-deficient youth using routine clinical data. While the XGBoost model demonstrates promising discriminative performance and geographic generalizability, the modest sample size and single-province validation limit immediate deployment readiness. Prospective multi-site validation is required before any consideration of clinical implementation as a developmental screening framework. CI - (c) AME Publishing Company. FAU - Bai, Jing AU - Bai J AD - Pediatric Department, Beijing Anzhen Nanchong Hospital of Capital Medical University & Nanchong Central Hospital, Nanchong, China. FAU - Fang, Xiao AU - Fang X AUID- ORCID: 0009-0005-7358-1349 AD - National Science Library (Chengdu), Chinese Academy of Sciences, Chengdu, China. FAU - Ding, Xiaoyan AU - Ding X AD - Pediatric Department, Beijing Anzhen Nanchong Hospital of Capital Medical University & Nanchong Central Hospital, Nanchong, China. FAU - Huang, Xiu AU - Huang X AD - Pediatric Department, Nanchong City Jialing District People's Hospital (Jialing Branch of Nanchong Central Hospital), Nanchong, China. LA - eng PT - Journal Article DEP - 20260515 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13351654 OTO - NOTNLM OT - Machine learning (ML) OT - children OT - external validation OT - insulin resistance (IR) OT - iron-deficiency COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-1-0146/coif). The authors have no conflicts of interest to declare. EDAT- 2026/07/11 16:11 MHDA- 2026/07/11 16:12 PMCR- 2026/06/30 CRDT- 2026/07/11 05:11 PHST- 2026/02/04 00:00 [received] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/07/11 16:12 [medline] PHST- 2026/07/11 16:11 [pubmed] PHST- 2026/07/11 05:11 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - tp-15-06-231 [pii] AID - 10.21037/tp-2026-1-0146 [doi] PST - ppublish SO - Transl Pediatr. 2026 Jun 30;15(6):231. doi: 10.21037/tp-2026-1-0146. Epub 2026 May 15. PMID- 42433955 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260711 LR - 20260813 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 6 DP - 2026 Jun 30 TI - Associations of picky eating levels with dietary diversity, nutrient intake, and eating behaviors in preschool children with autism spectrum disorder: a cross-sectional study. PG - 214 LID - 10.21037/tp-2026-1-0168 [doi] LID - 214 AB - BACKGROUND: Picky eating is common among children with autism spectrum disorder (ASD). However, the specific effects of different levels of picky eating on nutritional status, dietary diversity, and eating behaviors in preschool-aged children with ASD remain unclear. This study aimed to compare these aspects between children with low versus high levels of picky eating. METHODS: A cross-sectional study design was employed, enrolling 130 children with ASD aged 3 to 6 years who met the DSM-5 diagnostic criteria [Diagnostic and Statistical Manual of Mental Disorders Fourth Edition (DSM-V)]. Trained personnel measured each child's height and weight using standardized instruments. Validated dietary diversity scores and preschool eating behavior scales were used to assess dietary diversity and nutrient intake and eating behaviors. energy and macronutrient intake were quantified through three non-consecutive 24-hour dietary recalls. Children were divided into a low picky eating group and a high picky eating group based on the degree of picky eating for comparative analysis. RESULTS: There were no statistically significant differences in height and weight indicators between the two groups, with most children falling within the normal range of growth and development. However, distinct differences were observed in nutrient intake and eating behaviors: children in the low picky eating group showed significantly higher total dietary diversity scores (P<0.05). Regarding nutrient intake, children in the low picky eating group exhibited higher intake levels of total energy, polyunsaturated fatty acids, and dietary fiber compared to those in the high picky eating group; in specific food categories, intake of starchy tubers, fruits, nuts, and legumes was also significantly higher. Regarding eating behaviors, children in the low picky eating group showed lower scores for picky eating and problematic eating behaviors, whereas exhibited heightened satiety responsiveness, with all differences reaching statistical significance (P<0.05). CONCLUSIONS: The degree of picky eating is a key factor influencing dietary quality and eating behaviors in preschool-age children with ASD. Low levels of picky eating are associated with more comprehensive nutrient intake, richer dietary diversity, and more favorable eating behavior patterns. Early identification and intervention targeting picky eating behavior are of significant importance for improving the nutritional status of children with ASD. CI - (c) AME Publishing Company. FAU - Wang, Shasha AU - Wang S AD - Department of Pediatric Health Care, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Qi, Ye AU - Qi Y AD - Department of Pediatric Health Care, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Yao, Dan AU - Yao D AD - Department of Pediatric Health Care, The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. LA - eng PT - Journal Article DEP - 20260626 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13351710 OTO - NOTNLM OT - Autism spectrum disorder (ASD) OT - nutritional status OT - picky eating COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-1-0168/coif). The authors have no conflicts of interest to declare. EDAT- 2026/07/11 16:11 MHDA- 2026/07/11 16:12 PMCR- 2026/06/30 CRDT- 2026/07/11 05:11 PHST- 2026/02/14 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/07/11 16:12 [medline] PHST- 2026/07/11 16:11 [pubmed] PHST- 2026/07/11 05:11 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - tp-15-06-214 [pii] AID - 10.21037/tp-2026-1-0168 [doi] PST - ppublish SO - Transl Pediatr. 2026 Jun 30;15(6):214. doi: 10.21037/tp-2026-1-0168. Epub 2026 Jun 26. PMID- 42433928 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260711 LR - 20260813 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 6 DP - 2026 Jun 30 TI - Clinical phenotype, gonadal development, and comorbidity spectrum in 43 children with triple X syndrome: a single-center retrospective descriptive case series with cytogenetic refinement in patients with and without X-monosomy-containing cell lines. PG - 222 LID - 10.21037/tp-2026-0264 [doi] LID - 222 AB - BACKGROUND: Triple X syndrome (TXS) is a common yet under-diagnosed sex chromosome aneuploidy with significant phenotypic heterogeneity. Previous studies have typically described TXS as a homogeneous entity, lacking karyotype-stratified analysis. This study aimed to compare clinical phenotypes, gonadal development, and comorbidity profiles across karyotype subgroups in pediatric TXS patients. METHODS: This retrospective descriptive case series included 43 pediatric patients with TXS diagnosed at Jiangxi Provincial Children's Hospital between January 2019 and November 2024. Patients were classified into three groups: non-mosaic, X-monosomy mosaic (containing 45,X cell lines), and non-X-monosomy mosaic groups. Clinical data, including anthropometric measurements, sex hormones, pelvic ultrasound, bone age, and comorbidities, were collected. G-banding karyotyping was performed in all patients, and fluorescence in situ hybridization (FISH) was additionally performed in selected cases. Given the small subgroup sizes, analyses were descriptive without formal between-group hypothesis testing. RESULTS: Among the 43 patients, 31 (72.1%) were non-mosaic, 9 (20.9%) were X-monosomy mosaic, and 3 (7.0%) were non-X-monosomy mosaic. Fifteen patients (34.9%) experienced spontaneous menarche at a mean age of 11.13+/-1.28 years. The X-monosomy mosaic subgroup showed Turner syndrome-like features, including delayed bone age (mean difference +1.36 years), skeletal anomalies (3/9, 33.3%), and renal anomalies (2/9, 22.2%). Neuropsychiatric disorders were the most common comorbidity overall (11/43, 25.6%), particularly in the non-mosaic group. FISH refinement identified additional low-frequency cell lines in selected patients, highlighting cytogenetic complexity beyond routine karyotyping. CONCLUSIONS: In this descriptive single-center case series, patients with X-monosomy-containing cell lines were observed to have phenotypic features overlapping both Turner syndrome (disproportionate bone age delay, renal/skeletal anomalies) and typical 47,XXX (neuropsychiatric findings). Given the small subgroup sizes and the single-center design, these subgroup-level descriptions are presented to inform future hypothesis-driven studies rather than to support formal between-group conclusions. We outline a tentative, practice-informed framework intended to support-rather than replace-individualized multidisciplinary follow-up; prospective multi-center validation is required before adoption as a clinical management algorithm. CI - (c) AME Publishing Company. FAU - Feng, Ya-Qin AU - Feng YQ AUID- ORCID: 0009-0004-4489-3514 AD - Department of Endocrinology, Metabolism and Genetics, Jiangxi Provincial Children's Hospital, Nanchang, China. AD - Department of Endocrinology, Metabolism and Genetics, The Affiliated Children's Hospital of Nanchang Medical College, Nanchang, China. FAU - Li, Wen-Ting AU - Li WT AD - Department of Endocrinology, Metabolism and Genetics, The Affiliated Children's Hospital of Nanchang Medical College, Nanchang, China. AD - Department of Clinical Laboratory, Jiangxi Provincial Children's Hospital, Nanchang, China. FAU - Zou, Hai-Ying AU - Zou HY AD - Department of Endocrinology, Metabolism and Genetics, Jiangxi Provincial Children's Hospital, Nanchang, China. AD - Department of Endocrinology, Metabolism and Genetics, The Affiliated Children's Hospital of Nanchang Medical College, Nanchang, China. FAU - Xu, Qing-Bo AU - Xu QB AD - Department of Endocrinology, Metabolism and Genetics, Jiangxi Provincial Children's Hospital, Nanchang, China. AD - Department of Endocrinology, Metabolism and Genetics, The Affiliated Children's Hospital of Nanchang Medical College, Nanchang, China. FAU - Yang, Li AU - Yang L AUID- ORCID: 0009-0003-5209-4766 AD - Department of Endocrinology, Metabolism and Genetics, Jiangxi Provincial Children's Hospital, Nanchang, China. AD - Department of Endocrinology, Metabolism and Genetics, The Affiliated Children's Hospital of Nanchang Medical College, Nanchang, China. LA - eng PT - Journal Article DEP - 20260520 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13351657 OTO - NOTNLM OT - Triple X syndrome (TXS) OT - clinical phenotype OT - comorbidity OT - gonadal development OT - karyotype stratification COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-0264/coif). The authors have no conflicts of interest to declare. EDAT- 2026/07/11 06:36 MHDA- 2026/07/11 06:37 PMCR- 2026/06/30 CRDT- 2026/07/11 05:11 PHST- 2026/03/15 00:00 [received] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/07/11 06:37 [medline] PHST- 2026/07/11 06:36 [pubmed] PHST- 2026/07/11 05:11 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - tp-15-06-222 [pii] AID - 10.21037/tp-2026-0264 [doi] PST - ppublish SO - Transl Pediatr. 2026 Jun 30;15(6):222. doi: 10.21037/tp-2026-0264. Epub 2026 May 20. PMID- 42433503 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260711 LR - 20260813 IS - 2223-4292 (Print) IS - 2223-4306 (Electronic) IS - 2223-4306 (Linking) VI - 16 IP - 7 DP - 2026 Jul 1 TI - Correlation between the coronary computed tomography angiography-derived pericoronary fat attenuation index and coronary artery lesions in Kawasaki disease. PG - 544 LID - 10.21037/qims-2025-1-2749 [doi] LID - 544 AB - BACKGROUND: Kawasaki disease (KD), a type of acute systemic vasculitis that affects children, involves the coronary arteries and causes coronary artery lesions (CALs), including dilation, aneurysms, stenosis, and thrombosis. The pericoronary fat attenuation index (FAI), a novel biomarker of perivascular inflammation derived from coronary computed tomography angiography (CCTA), has been extensively validated in the context of adult coronary artery disease for stratifying plaque vulnerability and predicting future cardiac events. This study aimed to investigate the correlation between the FAI and the presence and severity of CALs in patients with KD. METHODS: We retrospectively analyzed the coronary computed tomography angiography (CTA) datasets of 71 patients with KD (40 with documented CALs and 31 without CALs) and 30 age- and sex-matched controls. Pericoronary FAI was measured around the proximal segments of all major coronary arteries. The global FAI values and their differences between groups were analyzed. The FAI values, clinical data, and coronary artery dimensions (Z-scores) were compared between groups. In statistical analyses, independent samples t-tests, Pearson or Spearman correlation coefficients, and multivariate logistic regression were applied to determine the independent association between FAI and CALs. RESULTS: Pericoronary FAI values were significantly higher in patients with KD and CALs than in those without CALs [-69.2+/-5.0 vs. -76.0+/-7.2 Hounsfield units (HU), P<0.001] and were higher in all patients with KD than in healthy controls (-72.1+/-6.9 vs. -77.6+/-7.5 HU, P<0.001). A significant positive correlation was observed between elevated FAI and the inflammation marker, peak erythrocyte sedimentation rate (ESR) (r=0.39; P<0.001), and severity of CALs, including the maximum coronary artery size (r=0.31; P<0.05) and Z-score (r=0.34; P<0.05). Multivariate analysis identified FAI as an independent factor associated with the presence of CALs [odds ratio (OR) =1.32; 95% confidence interval (CI): 1.15-1.51; P<0.001]. In predicting CALs in patients with KD, the FAI provided additional value [area under the curve (AUC) =0.935; 95% CI: 0.885-0.986] when combined with clinical parameters. CONCLUSIONS: The pericoronary FAI is significantly elevated in patients with KD and CALs and correlates with the severity of coronary involvement. FAI derived from routine coronary CTA may serve as a novel, noninvasive imaging biomarker for quantifying pericoronary inflammation and stratifying risk in patients with KD. CI - (c) AME Publishing Company. FAU - Chen, Xuezhen AU - Chen X AD - Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. AD - Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Shanwei, China. FAU - Zhou, Xiaolin AU - Zhou X AD - Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Shi, Jie AU - Shi J AD - Department of Ultrasonography, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Bai, Zhiqiang AU - Bai Z AD - Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Wang, Zhihui AU - Wang Z AD - Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Li, Pinggan AU - Li P AD - Department of Pediatrics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Li, Yong AU - Li Y AD - Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. LA - eng PT - Journal Article DEP - 20260610 PL - China TA - Quant Imaging Med Surg JT - Quantitative imaging in medicine and surgery JID - 101577942 PMC - PMC13349956 OTO - NOTNLM OT - Kawasaki disease (KD) OT - coronary artery lesions (CALs) OT - coronary computed tomography angiography (CCTA) OT - fat attenuation index (FAI) OT - pericoronary adipose tissue (PCAT) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://qims.amegroups.com/article/view/10.21037/qims-2025-1-2749/coif). The authors have no conflicts of interest to declare. EDAT- 2026/07/11 16:11 MHDA- 2026/07/11 16:12 PMCR- 2026/07/01 CRDT- 2026/07/11 05:07 PHST- 2025/12/19 00:00 [received] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/07/11 16:12 [medline] PHST- 2026/07/11 16:11 [pubmed] PHST- 2026/07/11 05:07 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - qims-16-07-544 [pii] AID - 10.21037/qims-2025-1-2749 [doi] PST - ppublish SO - Quant Imaging Med Surg. 2026 Jul 1;16(7):544. doi: 10.21037/qims-2025-1-2749. Epub 2026 Jun 10. PMID- 42433404 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Development and validation of a scale of healthy psychological effects of physical exercise among Chinese college students from a multidimensional mental health perspective. PG - 1866486 LID - 10.3389/fpubh.2026.1866486 [doi] LID - 1866486 AB - BACKGROUND: Physical exercise promotes mental health among college students, but existing studies often assess general mental health or limited psychological indicators, making it difficult to capture comprehensive healthy psychological effects after exercise. This study aimed to develop and validate the Healthy Psychological Effects of Physical Exercise Scale for College Students. METHODS: An initial scale was developed through theoretical analysis, literature review, semi-structured interviews, and open-ended questionnaires. In an initial sample of 612 college students, item analysis and exploratory factor analysis with varimax rotation were conducted to screen items and identify factor structures. A formal sample of 945 participants was used to examine reliability and validity through Cronbach's alpha, composite reliability (CR), average variance extracted (AVE), confirmatory factor analysis (CFA), and criterion-related validity testing. Test-retest reliability was assessed in 597 participants after 1 month. RESULTS: The final scale contained 55 items across five subscales: emotional feelings, self-cognition, frustration coping, self-control and social adaptation efficacy, and interpersonal interaction, comprising 15 subdimensions. Exploratory factor analyses supported clear three-factor structures for each subscale, with cumulative variance explained ranging from 62.546 to 73.711%. CFA indicated good fit for the five subscales (chi(2) /df = 2.978-4.391; RMSEA = 0.046-0.060; SRMR = 0.016-0.021; CFI = 0.978-0.988; TLI = 0.971-0.984), and acceptable fit for the overall model (chi(2) /df = 3.037; RMSEA = 0.046; SRMR = 0.041; CFI = 0.925; TLI = 0.921). Cronbach's alpha and CR for the 15 subdimensions ranged from 0.873 to 0.931, and AVE ranged from 0.680 to 0.736. Cronbach's alpha for the five subscale total scores ranged from 0.861 to 0.894. Test-retest reliability ranged from 0.706 to 0.781 for subdimensions and from 0.686 to 0.771 for subscale total scores. Criterion-related validity was supported by significant positive correlations with positive psychological indicators (r = 0.229-0.383) and negative correlations with negative psychological indicators (r = -0.398 to -0.224; all p < 0.001). CONCLUSION: The scale demonstrates sound reliability and validity and can be used to assess exercise-related healthy psychological effects among college students. CI - Copyright (c) 2026 Liu, Zhu, He, Zhu and Guo. FAU - Liu, Feiyang AU - Liu F AD - School of Physical Education, Southwest University, Chongqing, China. FAU - Zhu, Zhengguang AU - Zhu Z AD - Research Center of Mental Health Education, Southwest University, Chongqing, China. FAU - He, Rongqiao AU - He R AD - School of Physical Education, Southwest University, Chongqing, China. FAU - Zhu, Yu AU - Zhu Y AD - School of Physical Education, Southwest University, Chongqing, China. FAU - Guo, Liya AU - Guo L AD - School of Physical Education, Southwest University, Chongqing, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260626 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Students/psychology/statistics & numerical data MH - Female MH - Universities MH - Reproducibility of Results MH - *Exercise/psychology MH - Young Adult MH - Male MH - Surveys and Questionnaires/standards MH - *Mental Health MH - China MH - Psychometrics MH - Adolescent MH - Factor Analysis, Statistical MH - Adult MH - Adaptation, Psychological PMC - PMC13352479 OTO - NOTNLM OT - college students OT - healthy psychological effects OT - mental health OT - physical exercise OT - scale development COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/11 06:35 MHDA- 2026/07/12 00:55 PMCR- 2026/06/26 CRDT- 2026/07/11 05:06 PHST- 2026/04/27 00:00 [received] PHST- 2026/06/06 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/07/12 00:55 [medline] PHST- 2026/07/11 06:35 [pubmed] PHST- 2026/07/11 05:06 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1866486 [doi] PST - epublish SO - Front Public Health. 2026 Jun 26;14:1866486. doi: 10.3389/fpubh.2026.1866486. eCollection 2026. PMID- 42433322 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260711 LR - 20260813 IS - 2950-5410 (Electronic) IS - 2950-5410 (Linking) VI - 21 DP - 2026 Oct TI - Evaluating Empowerment in Adolescents with a Disability and/or Chronic Condition from Neurology and Orthopedic Clinics: A Mixed-Methods Study. PG - 200220 LID - 10.1016/j.jpedcp.2026.200220 [doi] LID - 200220 AB - OBJECTIVE: To evaluate empowerment and quality of life in adolescents (10-19 years of age) with chronic conditions and/or disabilities from neurology and orthopedic clinics and identify areas to improve their care and empowerment. STUDY DESIGN: We utilized a mixed-methods design with an explanatory sequential approach. Participants were recruited from neurology and orthopedic clinics at BC Children's Hospital and completed a demographic survey and two validated online tools: The Gothenburg Young Person's Empowerment Scale (GYPES) and Pediatric Quality of Life (PedsQL) 4.0 self-report. Semi-structured interviews were conducted to gain a deeper understanding of adolescents' feelings of empowerment. Linear regression analysis was performed to identify demographic variables associated with decreased empowerment and quality of life. Interviews were analyzed using an interpretive description framework. RESULTS: Forty-eight participants completed the survey. The mean reported GYPES and PedsQL scores were 58.15 +/- 8.46 and 61.57 +/- 22.32, respectively. Theoretical sufficiency was reached after 14 interviews. Four environmental factors leading to feelings promoting empowerment were identified: (1) shared decision-making enabled advocacy and independence, (2) education (particularly involving genetics) increased knowledge and understanding, (3) sharing stories led to empowering others, and (4) participation in physical activities promoted a sense of belonging. CONCLUSIONS: This study was the first to use the GYPES in adolescents with diverse disabilities and/or chronic conditions from neurology and orthopedic clinics. Adolescent patients felt empowered when they were actively involved in their health care and informed about the genetics of their diagnosis. Participants also wanted opportunities to empower others going through similar experiences. This study emphasizes the need for access to genetic counseling and opportunities for shared expression to facilitate empowerment. CI - (c) 2026 The Author(s). FAU - Austin, Kennedy AU - Austin K AD - Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. FAU - Selby, Kathryn AU - Selby K AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. AD - Division of Neurology, Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada. FAU - Virani, Alice AU - Virani A AD - Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. AD - Ethics Service, Provincial Health Services Authority, Vancouver, BC, Canada. FAU - Ross, Colin AU - Ross C AD - Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. AD - Centre for Advancing Health Outcomes, St Paul's Hospital, Vancouver, BC, Canada. AD - Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada. FAU - Chhina, Harpreet AU - Chhina H AD - Department of Orthopedics, University of British Columbia, Vancouver, BC, Canada. FAU - Cooper, Anthony AU - Cooper A AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. AD - Department of Orthopedics, University of British Columbia, Vancouver, BC, Canada. AD - Department of Orthopedics, BC Children's Hospital, Vancouver, BC, Canada. FAU - Elliott, Alison M AU - Elliott AM AD - Department of Medical Genetics, University of British Columbia, Vancouver, BC, Canada. AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. AD - Women's Health Research Institute, Vancouver, BC, Canada. LA - eng PT - Journal Article DEP - 20260606 PL - United States TA - J Pediatr Clin Pract JT - Journal of pediatrics. Clinical practice JID - 9918769578606676 PMC - PMC13352426 OTO - NOTNLM OT - adolescents OT - chronic condition OT - disability OT - empowerment COIS- K.A. was the recipient of the 10.13039/501100000024Canadian Institutes of Health Research (CIHR) Canadian Graduate Scholarship Master's award, through which this project was funded. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/11 06:35 MHDA- 2026/07/11 06:36 PMCR- 2026/06/06 CRDT- 2026/07/11 05:05 PHST- 2025/12/04 00:00 [received] PHST- 2026/05/26 00:00 [revised] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/07/11 06:36 [medline] PHST- 2026/07/11 06:35 [pubmed] PHST- 2026/07/11 05:05 [entrez] PHST- 2026/06/06 00:00 [pmc-release] AID - S2950-5410(26)00021-9 [pii] AID - 200220 [pii] AID - 10.1016/j.jpedcp.2026.200220 [doi] PST - epublish SO - J Pediatr Clin Pract. 2026 Jun 6;21:200220. doi: 10.1016/j.jpedcp.2026.200220. eCollection 2026 Oct. PMID- 42433286 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260711 LR - 20260813 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Sports and physical activity interventions in autism spectrum disorder: a systematic literature review and meta-analysis. PG - 1793290 LID - 10.3389/fspor.2026.1793290 [doi] LID - 1793290 AB - BACKGROUND: Physical activity (PA) interventions have been explored as a means of improving motor, social, executive, behavioural, and psychosocial outcomes in children and adolescents with autism spectrum disorder (ASD). However, variability in study designs and methodological quality raises questions about the consistency and reliability of reported effects. METHODS: A systematic review and meta-analysis were conducted, including studies published between 2019 and 2025. Eighteen studies met the inclusion criteria for qualitative synthesis, and twelve were included in the meta-analysis using a random-effects model. Effect sizes were calculated and pooled across outcome domains. Risk of bias was assessed, and additional analyses were conducted to examine heterogeneity and potential publication bias. RESULTS: PA interventions were associated with improvements across multiple domains. The pooled effect size was large (d approximately 1.28), but substantial heterogeneity across study designs, intervention types, and sample characteristics was observed. Subgroup analyses indicated variation in effects across intervention types and participant groups, though findings were not consistently stable. Risk-of-bias assessments identified several methodological limitations, and publication bias analyses suggested possible asymmetry. These factors indicate that the magnitude of the pooled effect size may be overestimated. CONCLUSION: PA interventions show promise for supporting multidomain development in children and adolescents with ASD. However, the certainty of evidence ranges from low to moderate, and findings should be interpreted cautiously. Future research should prioritise rigorous study designs, larger samples, and consistent reporting of intervention fidelity and long-term outcomes to strengthen the evidence base. CI - (c) 2026 Jacob, Nurhayati and Maguvhe. FAU - Jacob, Udeme Samuel AU - Jacob US AD - Department of Inclusive Education, School of Educational Studies, College of Education, University of South Africa, Pretoria, South Africa. FAU - Nurhayati, Sri AU - Nurhayati S AD - Department of Community Education, Postgraduate Program, Institut Keguruan dan Ilmu Pendidikan Siliwangi, Cimahi, Indonesia. FAU - Maguvhe, Mbulaheni Obert AU - Maguvhe MO AD - Department of Inclusive Education, School of Educational Studies, College of Education, University of South Africa, Pretoria, South Africa. LA - eng PT - Journal Article DEP - 20260626 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13350350 OTO - NOTNLM OT - autism spectrum disorder OT - children and adolescents OT - executive function OT - intervention OT - meta-analysis OT - motor skills OT - physical activity OT - social communication COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/11 06:35 MHDA- 2026/07/11 06:36 PMCR- 2026/06/26 CRDT- 2026/07/11 05:04 PHST- 2026/01/21 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/07/11 06:36 [medline] PHST- 2026/07/11 06:35 [pubmed] PHST- 2026/07/11 05:04 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 10.3389/fspor.2026.1793290 [doi] PST - epublish SO - Front Sports Act Living. 2026 Jun 26;8:1793290. doi: 10.3389/fspor.2026.1793290. eCollection 2026. PMID- 42432606 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260911 IS - 1472-6823 (Electronic) IS - 1472-6823 (Linking) VI - 26 IP - 1 DP - 2026 Jul 10 TI - Predictive models of adverse outcomes of overweight or obesity: a nationwide cohort validation. LID - 10.1186/s12902-026-02399-4 [doi] LID - 265 AB - BACKGROUND: Obesity and overweight have a wide range of adverse clinical outcomes. Predictive models could help clinicians identify individuals with obesity and overweight at greater risk for obesity-related complications, enabling personalized shared decision-making about obesity treatment. We previously developed a set of predictive models of adverse clinical outcomes of obesity and overweight using electronic health record (EHR) data of a large health system in Massachusetts. However, these models have not been validated on data from other sources. METHODS: We validated 12 predictive models for cardiometabolic, oncologic and musculoskeletal complications of excess weight using a linked EHR and claims dataset of a national patient cohort (Optum((R)) Market Clarity) that included adults 18-80 years of age with body mass index (BMI) >/= 25 kg/m(2) between 2007 and 2023. RESULTS: A 5% randomly selected validation dataset included 437,223 patients (51.9% women) with a mean age of 51.4 years and a mean BMI of 31.9 kg/m(2) who were followed for a mean of 5.7 years. Most (11/12) models achieved Harrell C-index >/= 0.70. Most (11/12) models had either 5-year or 10-year calibration slope within 0.3 of the ideal value of 1.0; 7 out of 12 had either 5-year or 10-year calibration slope that was not significantly different from 1.0; all had intercepts very close to 0. CONCLUSIONS: A set of EHR-based predictive models of adverse outcomes of obesity and overweight was generalizable to a large national cohort. These findings suggest potential clinical and population health applications for predictive models in treatment of individual patients with obesity / overweight, as well as in population management and quality improvement. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2026. The Author(s). FAU - Turchin, Alexander AU - Turchin A AUID- ORCID: 0000-0002-8609-564X AD - Brigham and Women's Hospital, Boston, MA, USA. aturchin@bwh.harvard.edu. AD - Harvard Medical School, Boston, MA, USA. aturchin@bwh.harvard.edu. FAU - Shubina, Maria AU - Shubina M AD - Brigham and Women's Hospital, Boston, MA, USA. FAU - Morrison, Fritha J AU - Morrison FJ AD - Brigham and Women's Hospital, Boston, MA, USA. FAU - Ahmad, Nadia N AU - Ahmad NN AD - Eli Lilly and Company, Indianapolis, IN, USA. FAU - Neff, Lisa M AU - Neff LM AD - Eli Lilly and Company, Indianapolis, IN, USA. FAU - Kan, Hong AU - Kan H AD - Eli Lilly and Company, Indianapolis, IN, USA. LA - eng PT - Journal Article PT - Validation Study DEP - 20260710 PL - England TA - BMC Endocr Disord JT - BMC endocrine disorders JID - 101088676 SB - IM MH - Humans MH - Female MH - *Obesity/complications/epidemiology MH - Middle Aged MH - *Overweight/complications/epidemiology MH - Male MH - Aged MH - Adult MH - Body Mass Index MH - Prognosis MH - Aged, 80 and over MH - Young Adult MH - Adolescent MH - Electronic Health Records/statistics & numerical data MH - Prediction Algorithms MH - Cohort Studies MH - Follow-Up Studies PMC - PMC13556077 OTO - NOTNLM OT - Long-term outcomes OT - Obesity OT - Overweight OT - Predictive modeling OT - Validation COIS- Declarations. Ethics approval and consent to participate: This study followed the principles outlined in the Helsinki Declaration. The study was approved by the Mass General Brigham institutional review board (protocol # 2021P003735), and the requirement for informed consent was waived. Consent for publication: Not applicable. Competing interests: Turchin reports consulting for Novo Nordisk and Proteomics International; research and travel support from Eli Lilly and Company; and research support from Novo Nordisk. Ahmad, Neff and Kan are employees and stockholders of Eli Lilly and Company. None of the other authors report any conflicts of interest. EDAT- 2026/07/11 05:37 MHDA- 2026/09/09 07:07 PMCR- 2026/07/10 CRDT- 2026/07/10 23:47 PHST- 2025/05/12 00:00 [received] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/09/09 07:07 [medline] PHST- 2026/07/11 05:37 [pubmed] PHST- 2026/07/10 23:47 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - 10.1186/s12902-026-02399-4 [pii] AID - 2399 [pii] AID - 10.1186/s12902-026-02399-4 [doi] PST - epublish SO - BMC Endocr Disord. 2026 Jul 10;26(1):265. doi: 10.1186/s12902-026-02399-4. PMID- 42432565 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261016 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jul 10 TI - Exploring the role of non-formal training in an international youth mobility on young adult's perception of appearance and dental aesthetics. LID - 10.1186/s12903-026-09109-5 [doi] LID - 2017 AB - BACKGROUND: Dental aesthetic concerns in young adults are shaped by sociocultural appearance pressures and media-derived ideals, yet education-based interventions targeting these upstream determinants have received limited attention in dentistry. This exploratory study examined whether a brief non-formal educational programme delivered within an Erasmus+ youth mobility context was associated with short-term changes in sociocultural appearance attitudes and the psychosocial impact of dental aesthetics. METHODS: A single-group, quasi-experimental pre-test/post-test design was used. Thirty-four young adults (aged 18-30; 23 from Turkiye, 11 from France) completed the Sociocultural Attitudes Toward Appearance Questionnaire-4 (SATAQ-4) and the Psychosocial Impact of Dental Aesthetics Questionnaire (PIDAQ) immediately before (T0) and immediately after (T1) a five-day programme integrating media literacy, body-positivity activities, and oral health education. Pre-post differences were tested using Wilcoxon signed-rank tests with Holm adjustment, with rank-biserial correlations as effect sizes. Internal consistency was estimated using Cronbach's alpha and McDonald's omega. Reporting followed the TREND and TIDieR guidelines. RESULTS: From T0 to T1, SATAQ-4 total scores decreased (r_rb = - 0.782, 95% CI [- 0.956, - 0.536]) and PIDAQ total scores decreased (r_rb = - 0.655, 95% CI [- 0.882, - 0.345]). All subscales showed changes in the direction anticipated by the study hypothesis, with reductions in negative PIDAQ domains and an increase in Dental Self-Confidence. All comparisons remained significant after Holm adjustment (p_Holm SC(2) (beta = 0.041, p < .001), PA(1) --> SD(2) (beta = 0.018, p < .05), and PA(1) --> MH(2) (beta = -0.023, p < .05). SC(1) --> MH(2) (beta = -0.034, p < .01). MH(1) --> PA(2) (beta = -0.038, p < .001), and SD(1) --> PA(2) (beta = 0.014, p < .05). Indirect effect PA(1) --> SC(2) --> PC(2) was significant (standardized = -0.001; 95% CI [-0.003, -0.001]). Gender group comparison showed no significant differences (Deltachi(2) (5) = 8.10, p = .16). CONCLUSIONS: PA and PC exert reciprocal influences in adolescents, with higher PA predicting improved SC, better SD, and reduced MH, while psychosomatic distress undermines subsequent PA and SC. SC partially mediates PA's protective effects on comorbidity, with equivalent patterns across genders. Interventions combining PA and social-skills training may disrupt the vicious cycle of adolescent PC. CI - (c) 2026 Association for Child and Adolescent Mental Health. FAU - Guo, Xinmeng AU - Guo X AUID- ORCID: 0000-0002-0432-6118 AD - School of Physical Education, Shandong University, Jinan, China. FAU - Yi, Nuo AU - Yi N AD - Physical medicine and rehabilitation, Christus Health, Canton, TX, USA. FAU - Lai, Xinxin AU - Lai X AD - School of Physical Education, Shandong University, Jinan, China. FAU - Yi, Xiangren AU - Yi X AD - School of Physical Education, Shandong University, Jinan, China. FAU - Dong, Xiaosheng AU - Dong X AUID- ORCID: 0000-0003-0507-2938 AD - School of Physical Education, Shandong University, Jinan, China. AD - Department of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China. AD - NHC Key Lab of Health Economics and Policy Research (Shandong University), Jinan, China. AD - Center for Health Management and Policy Research, Shandong University (Shandong Provincial Key New Think Tank), Jinan, China. LA - eng PT - Journal Article DEP - 20260710 PL - England TA - J Child Psychol Psychiatry JT - Journal of child psychology and psychiatry, and allied disciplines JID - 0375361 SB - IM OTO - NOTNLM OT - Physical activity OT - adolescents OT - cross-lagged model OT - psychosomatic comorbidity OT - social competence EDAT- 2026/07/11 05:39 MHDA- 2026/07/11 05:39 CRDT- 2026/07/10 23:03 PHST- 2026/06/04 00:00 [accepted] PHST- 2026/07/11 05:39 [medline] PHST- 2026/07/11 05:39 [pubmed] PHST- 2026/07/10 23:03 [entrez] AID - 10.1111/jcpp.70193 [doi] PST - aheadofprint SO - J Child Psychol Psychiatry. 2026 Jul 10. doi: 10.1111/jcpp.70193. PMID- 42431813 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20260921 IS - 2352-7226 (Electronic) IS - 2352-7218 (Linking) VI - 12 IP - 5 DP - 2026 Oct TI - Sleep problems and underweight among adolescent girls and adult women aged 12-49 years: A cross-sectional, web-based survey in Japan. PG - 778-785 LID - S2352-7218(26)00127-0 [pii] LID - 10.1016/j.sleh.2026.06.005 [doi] AB - OBJECTIVES: Underweight is a common health concern among individuals of reproductive age. Although sleep and metabolic regulation share neuroendocrine pathways, the relationship between underweight and sleep problems remains unclear. This study aimed to investigate the associations between underweight and questionnaire-based sleep-related outcomes among adolescent girls and adult women. METHODS: These cross-sectional, web-based surveys were conducted from November to December 2023 among adolescent girls (aged 12-18 years) and adult women aged 18 to 49 years. Valid responses were obtained from 996 adolescent girls and 4689 adult women. Logistic regression analyses were conducted within age-defined subgroups to examine associations between weight categories and sleep-related outcomes, including a sleep debt-related pattern with daytime sleepiness and self-reported insomnia symptoms, adjusting for sociodemographic and lifestyle factors. RESULTS: Among respondents, 14.7% of adolescent girls and 23.5% of adult women were underweight. Underweight was not associated with either of the sleep-related outcomes among adolescent girls. In adult women, underweight was associated with self-reported insomnia symptoms in women in their 20s, with no associations observed in other age groups. An interaction between age and underweight was observed, suggesting that this association weakened with increasing age. CONCLUSIONS: Underweight was associated with self-reported insomnia symptoms, but not with a sleep debt-related pattern with daytime sleepiness, among adult women in their 20s. These findings suggest that sleep assessment may be considered as part of comprehensive strategies addressing underweight, although further studies using validated sleep measures are needed. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Kayaba, Momoko AU - Kayaba M AD - International Institute for Integrative Sleep Medicine, University of Tsukuba, Tsukuba, Ibaraki, Japan. Electronic address: momoko.kayaba@gmail.com. FAU - Ogata, Hitomi AU - Ogata H AD - Graduate School of Humanities and Social Sciences, Hiroshima University, Hiroshima, Japan. FAU - Yumen, Yukina AU - Yumen Y AD - Graduate school of Human Science and Environment, University of Hyogo, Himeji, Hyogo, Japan. FAU - Takayama, Yumi AU - Takayama Y AD - Graduate school of Human Science and Environment, University of Hyogo, Himeji, Hyogo, Japan. FAU - Kiyono, Ken AU - Kiyono K AD - Graduate School of Engineering Science, The University of Osaka, Toyonaka, Osaka, Japan. FAU - Nose-Ogura, Sayaka AU - Nose-Ogura S AD - Department of Sport Medicine and Research, Japan Institute Sports Sciences, Japan High-Performance Sport Center, kita-ku, Tokyo, Japan. FAU - Nagai, Narumi AU - Nagai N AD - Graduate school of Human Science and Environment, University of Hyogo, Himeji, Hyogo, Japan. LA - eng PT - Journal Article DEP - 20260711 PL - United States TA - Sleep Health JT - Sleep health JID - 101656808 SB - IM MH - *Sleep Initiation and Maintenance Disorders MH - *Thinness/epidemiology MH - Japan/epidemiology MH - Cross-Sectional Studies MH - Humans MH - Male MH - Female MH - Child MH - Adolescent MH - Young Adult MH - Adult OTO - NOTNLM OT - Adolescent girls OT - Adult women OT - Reproductive age OT - Sleep OT - Underweight COIS- Declaration of conflicts of interest The authors have declared no conflicts of interest. EDAT- 2026/07/11 05:37 MHDA- 2026/09/17 23:34 CRDT- 2026/07/10 21:53 PHST- 2025/11/06 00:00 [received] PHST- 2026/06/18 00:00 [revised] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/09/17 23:34 [medline] PHST- 2026/07/11 05:37 [pubmed] PHST- 2026/07/10 21:53 [entrez] AID - S2352-7218(26)00127-0 [pii] AID - 10.1016/j.sleh.2026.06.005 [doi] PST - ppublish SO - Sleep Health. 2026 Oct;12(5):778-785. doi: 10.1016/j.sleh.2026.06.005. Epub 2026 Jul 11. PMID- 42431596 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260901 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 124 IP - 3 DP - 2026 Sep TI - Maternal Intake of Vitamins A, C, D, and E During Pregnancy and Risk of Type 1 Diabetes in the Child: The Norwegian Mother, Father, and Child Cohort Study. PG - 101431 LID - S0002-9165(26)00240-6 [pii] LID - 10.1016/j.ajcnut.2026.101431 [doi] AB - BACKGROUND: Dietary vitamins play a role in antioxidant defense and immunoregulation. However, prospective studies exploring the association between vitamin intakes during pregnancy and the child's risk of type 1 diabetes are limited. OBJECTIVES: This population-based prospective cohort study aimed to investigate the association between maternal intake of vitamins A, C, D, and E during pregnancy and risk of type 1 diabetes in children. METHODS: We included 85,244 children born between 2002 and 2009 in the Norwegian Mother and Child Cohort Study, with follow-up until 31 December, 2021. Maternal intake of vitamins from food and dietary supplements from conception to the 22nd week of pregnancy was assessed with a validated food frequency questionnaire. Cox proportional hazards regression was used to estimate hazard ratios (HRs), adjusting for background factors. RESULTS: During follow-up, 529 (0.6%) children were diagnosed with type 1 diabetes at a mean age of 9.4 y (standard deviation: 4.1 y) No associations were observed between maternal pregnancy intake of vitamin A [HR: 0.993; 95% confidence interval (CI): 0.983, 1.003/100 mug], vitamin C (HR: 1.000; 95% CI: 0.993, 1.007/10 mg), vitamin D (HR: 0.991; 95% CI: 0.978, 1.003/1 mug), or vitamin E (HR: 0.999; 95% CI: 0.996, 1.004/10 mg) and risk of type 1 diabetes in the child when adjusted for potential confounders. The results were similar when intakes were assessed separately from food and dietary supplements and after restriction to children with human leukocyte antigen DQ2 and/or DQ8 risk haplotypes. CONCLUSIONS: This prospective cohort study does not support the hypothesis that higher maternal intake of vitamins A, C, D, and E during pregnancy would decrease risk of type 1 diabetes in the child. Corroborated with previous evidence, our findings support a general pattern of null associations. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Mattila, Markus AU - Mattila M AD - Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, Finland; Wellbeing Services County of Pirkanmaa, Tampere University Hospital, Tampere, Finland; Department of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland; Centre for Child, Adolescent and Maternal Health Research (TamCM), Tampere University, Tampere, Finland. Electronic address: markus.mattila@tuni.fi. FAU - Tapia, German AU - Tapia G AD - Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway. FAU - Stordal, Ketil AU - Stordal K AD - Department of Pediatric Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Pediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. FAU - Brantsaeter, Anne-Lise AU - Brantsaeter AL AD - Department of Food Safety, Norwegian Institute of Public Health, Oslo, Norway; Centre for Sustainable Diets, Norwegian Institute of Public Health, Oslo, Norway. FAU - Virtanen, Suvi M AU - Virtanen SM AD - Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, Finland; Wellbeing Services County of Pirkanmaa, Tampere University Hospital, Tampere, Finland; Centre for Child, Adolescent and Maternal Health Research (TamCM), Tampere University, Tampere, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland. FAU - Lund-Blix, Nicolai A AU - Lund-Blix NA AD - The Norwegian Childhood Diabetes Registry, Division of Childhood and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. FAU - Skrivarhaug, Torild AU - Skrivarhaug T AD - Department of Food Safety, Norwegian Institute of Public Health, Oslo, Norway; Centre for Sustainable Diets, Norwegian Institute of Public Health, Oslo, Norway; The Norwegian Childhood Diabetes Registry, Division of Childhood and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Oslo Diabetes Research Centre, Oslo University Hospital, Oslo, Norway. FAU - Hard Af Segerstad, Elin M AU - Hard Af Segerstad EM AD - Pediatric Research Institute, Oslo University Hospital, Oslo, Norway; Unit of Celiac Disease and Diabetes, Clinical Sciences Malmo, Lund University, Malmo, Sweden. FAU - Stene, Lars C AU - Stene LC AD - Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway; Oslo Diabetes Research Centre, Oslo University Hospital, Oslo, Norway. CN - HEDIMED Investigator Group LA - eng PT - Journal Article DEP - 20260710 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 RN - 0 (Vitamins) RN - 11103-57-4 (Vitamin A) RN - 1406-16-2 (Vitamin D) RN - 1406-18-4 (Vitamin E) RN - PQ6CK8PD0R (Ascorbic Acid) SB - IM MH - Humans MH - Female MH - *Diabetes Mellitus, Type 1/epidemiology/prevention & control MH - Pregnancy MH - Norway/epidemiology MH - Prospective Studies MH - Child MH - Dietary Supplements MH - Male MH - *Vitamins/administration & dosage MH - Vitamin A/administration & dosage MH - Vitamin D/administration & dosage MH - Vitamin E/administration & dosage MH - *Maternal Nutritional Physiological Phenomena MH - Adult MH - Ascorbic Acid/administration & dosage MH - Cohort Studies MH - Risk Factors OTO - NOTNLM OT - MoBa OT - diabetes mellitus OT - diet OT - dietary supplements OT - observational study OT - pregnancy OT - type 1 OT - vitamins COIS- Conflict of interest The authors report no conflicts of interest. FIR - Kristi, Hoffman IR - Kristi H IRAD- Baylor College of Medicine, Department of Molecular Virology and Microbiology. FIR - Sara, Javornik Cregeen IR - Sara JC IRAD- Baylor College of Medicine, Department of Molecular Virology and Microbiology. FIR - Joseph, Petrosino IR - Joseph P IRAD- Baylor College of Medicine, Department of Molecular Virology and Microbiology. FIR - Tasha, Santiago Rodriguez IR - Tasha SR IRAD- Baylor College of Medicine, Department of Molecular Virology and Microbiology. FIR - Ondrej, Cinek IR - Ondrej C IRAD- Charles University, 2nd Faculty of Medicine. FIR - Eva, Fronkova IR - Eva F IRAD- Charles University, 2nd Faculty of Medicine. FIR - Hans, Bisgaard IR - Hans B IRAD- COPSAC. FIR - Klaus, Bonnelykke IR - Klaus B IRAD- COPSAC. FIR - Sarah, Brandt IR - Sarah B IRAD- COPSAC. FIR - Astrid, Sevelsted IR - Astrid S IRAD- COPSAC. FIR - Shiraz, Shah IR - Shiraz S IRAD- COPSAC. FIR - Jakob, Stokholm IR - Jakob S IRAD- COPSAC. FIR - Jonathan, Thorsen IR - Jonathan T IRAD- COPSAC. FIR - Jaroslav, Havlik IR - Jaroslav H IRAD- Czech University of Life Sciences Prague, Department of Food Science. FIR - Eliska, Jenickova IR - Eliska J IRAD- Czech University of Life Sciences Prague, Department of Food Science. FIR - Daniel, Schmidtmann IR - Daniel S IRAD- Empirica. FIR - Rainer, Thiel IR - Rainer T IRAD- Empirica. FIR - Leena, Hakola IR - Leena H IRAD- Finnish Institute for Health and Welfare, The Department of Health Security and The Department of Public Health and Welfare. FIR - Hannu, Kiviranta IR - Hannu K IRAD- Finnish Institute for Health and Welfare, The Department of Health Security and The Department of Public Health and Welfare. FIR - Panu, Rantakokko IR - Panu R IRAD- Finnish Institute for Health and Welfare, The Department of Health Security and The Department of Public Health and Welfare. FIR - Suvi M, Virtanen IR - Suvi M V IRAD- Finnish Institute for Health and Welfare, The Department of Health Security and The Department of Public Health and Welfare. FIR - Alexander, Berler IR - Alexander B IRAD- Gnomon. FIR - Apostolia, Karabatea IR - Apostolia K IRAD- Gnomon. FIR - Korina, Papadopoulou IR - Korina P IRAD- Gnomon. FIR - Gabriele, Berg IR - Gabriele B IRAD- Graz University of Technology, Institute of Environmental Biotechnology. FIR - Wisnu, Wicaksono IR - Wisnu W IRAD- Graz University of Technology, Institute of Environmental Biotechnology. FIR - Daniel, Agardh IR - Daniel A IRAD- Lund University, Department of Clinical Sciences. FIR - Andren, Aronsson Carin IR - Andren AC IRAD- Lund University, Department of Clinical Sciences. FIR - Markus, Lundgren IR - Markus L IRAD- Lund University, Department of Clinical Sciences. FIR - Bostrom, Michaela IR - Bostrom M IRAD- Lund University, Department of Clinical Sciences. FIR - Marja, Roslund IR - Marja R IRAD- Natural Resources Institute Finland, Horticulture Technologies. FIR - Aki, Sinkkonen IR - Aki S IRAD- Natural Resources Institute Finland, Horticulture Technologies. FIR - Sara, Alibakhshi IR - Sara A IRAD- Satellio. FIR - Lauri, Hame IR - Lauri H IRAD- Satellio. FIR - Patricia-Daiana, Boia IR - Patricia-Daiana B IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Loic, Burr IR - Loic B IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Stefano, Cattaneo IR - Stefano C IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Peter, Cristofollini IR - Peter C IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Silvia, Demuru IR - Silvia D IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Silvia, Generelli IR - Silvia G IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Nicola, Hermann IR - Nicola H IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Hui, Chai-Gao IR - Hui CG IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Samantha, Paoletti IR - Samantha P IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Bradley, Petkus IR - Bradley P IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Edith, Ruth IR - Edith R IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Yevhen, Shynkarenko IR - Yevhen S IRAD- Swiss Center for Electronics and Microtechnology (CSEM). FIR - Erika, Antola IR - Erika A IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Anna, Euren IR - Anna E IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Heikki, Hyoty IR - Heikki H IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Nanna, Kangasmaki IR - Nanna K IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Laura, Kivela IR - Laura K IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Kalle, Kurppa IR - Kalle K IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Jutta, Laiho IR - Jutta L IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Olli, Laitinen IR - Olli L IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Jussi, Lehtonen IR - Jussi L IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Jake, Lin IR - Jake L IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Katri, Lindfors IR - Katri L IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Maria, Lonnrot IR - Maria L IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Johannes, Malkamaki IR - Johannes M IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Jani, Makinen IR - Jani M IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Henna, Numminen IR - Henna N IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Noora, Nurminen IR - Noora N IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Matti, Nykter IR - Matti N IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Sami, Oikarinen IR - Sami O IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Maarit, Oikarinen IR - Maarit O IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Tiina, Palmu IR - Tiina P IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Leena, Puustinen IR - Leena P IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Niila, Saarinen IR - Niila S IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Erika, Seppala IR - Erika S IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Miia, Siljavaara IR - Miia S IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Amirbabak, Sioofy-Khojine IR - Amirbabak SK IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Minna, Turppa IR - Minna T IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Keijo, Viiri IR - Keijo V IRAD- Tampere University, Faculty of Medicine and Health Technology. FIR - Mikael, Knip IR - Mikael K IRAD- Tampere University Hospital. FIR - Aleksandr, Peet IR - Aleksandr P IRAD- Tartu University Hospital. FIR - Kart, Simre IR - Kart S IRAD- Tartu University Hospital. FIR - Vallo, Tillmann IR - Vallo T IRAD- Tartu University Hospital. FIR - Elin, Hard Af Segerstad IR - Elin HAS IRAD- The Norwegian Institute of Public Health. FIR - Nicolai A, Lund-Blix IR - Nicolai A LB IRAD- The Norwegian Institute of Public Health. FIR - Maria, Magnus IR - Maria M IRAD- The Norwegian Institute of Public Health. FIR - Aino-Kaisa, Rantala IR - Aino-Kaisa R IRAD- The Norwegian Institute of Public Health. FIR - Lars, Stene IR - Lars S IRAD- The Norwegian Institute of Public Health. FIR - Ketil, Stordal IR - Ketil S IRAD- The Norwegian Institute of Public Health. FIR - German, Tapia IR - German T IRAD- The Norwegian Institute of Public Health. FIR - Iida, Makela IR - Iida M IRAD- University of Helsinki, Faculty of Biological and Environmental Sciences. FIR - Martin, Romantschuk IR - Martin R IRAD- University of Helsinki, Faculty of Biological and Environmental Sciences. FIR - Laura, Soininen IR - Laura S IRAD- University of Helsinki, Faculty of Biological and Environmental Sciences. FIR - Tiia, Honkanen IR - Tiia H IRAD- University of Oulu, Department of Paediatrics. FIR - Juho, Pietila IR - Juho P IRAD- University of Oulu, Department of Paediatrics. FIR - Nelli, Ronka IR - Nelli R IRAD- University of Oulu, Department of Paediatrics. FIR - Toni, Valtanen IR - Toni V IRAD- University of Oulu, Department of Paediatrics. FIR - Riitta, Veijola IR - Riitta V IRAD- University of Oulu, Department of Paediatrics. FIR - Elena, Bargagli IR - Elena B IRAD- University of Siena, Department of Medicine, Surgery and Neuroscience. FIR - Francesco, Dotta IR - Francesco D IRAD- University of Siena, Department of Medicine, Surgery and Neuroscience. FIR - Laura, Nigi IR - Laura N IRAD- University of Siena, Department of Medicine, Surgery and Neuroscience. FIR - Guido, Sebastiani IR - Guido S IRAD- University of Siena, Department of Medicine, Surgery and Neuroscience. FIR - Alar, Aints IR - Alar A IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Kristi, Alnek IR - Kristi A IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Anu, Barenson IR - Anu B IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Anne, Kirss IR - Anne K IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Ivo, Laidmae IR - Ivo L IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Astrid, Oras IR - Astrid O IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Aili, Tagoma IR - Aili T IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Raivo, Uibo IR - Raivo U IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Tamara, Vorobjova IR - Tamara V IRAD- University of Tartu, Department of Immunology, Institute of Pharmacy. FIR - Iltana, Bojovic IR - Iltana B IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Laura, Elo IR - Laura E IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Karoliina, Hirvonen IR - Karoliina H IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Sini, Junttila IR - Sini J IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Jalmari, Kettunen IR - Jalmari K IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Riitta, Lahesmaa IR - Riitta L IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Johanna, Lempainen IR - Johanna L IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Robert, Moulder IR - Robert M IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Omid, Rasool IR - Omid R IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Inna, Starskaia IR - Inna S IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Tomi, Suomi IR - Tomi S IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Jorma, Toppari IR - Jorma T IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Ubaid, Ullah IR - Ubaid U IRAD- University of Turku, Turku Bioscience Centre (University of Turku and Abo Akademi University), Institute of Biomedicine, Department of Paediatrics. FIR - Barannik, Emilia IR - Barannik E IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Jean Eudes, Gbodjo Yawogan IR - Jean Eudes GY IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Matthieu, Molinier IR - Matthieu M IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Tarja, Nevanen IR - Tarja N IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Juha, Pajula IR - Juha P IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Juha, Parkka IR - Juha P IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Jukka, Ranta IR - Jukka R IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Jyri, Rokman IR - Jyri R IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Petri, Saviranta IR - Petri S IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Peter, Ylen IR - Peter Y IRAD- VTT Technical Research Centre of Finland Ltd. FIR - Eija, Parmes IR - Eija P IRAD- VTT Technical Research Centre of Finland Ltd. EDAT- 2026/07/11 05:37 MHDA- 2026/09/01 23:34 CRDT- 2026/07/10 19:17 PHST- 2026/03/17 00:00 [received] PHST- 2026/07/04 00:00 [revised] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/09/01 23:34 [medline] PHST- 2026/07/11 05:37 [pubmed] PHST- 2026/07/10 19:17 [entrez] AID - S0002-9165(26)00240-6 [pii] AID - 10.1016/j.ajcnut.2026.101431 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Sep;124(3):101431. doi: 10.1016/j.ajcnut.2026.101431. Epub 2026 Jul 10. PMID- 42431240 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260907 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 227 DP - 2026 Dec 1 TI - Associations between the residential food environment and diet: The Generation R Study. PG - 108717 LID - S0195-6663(26)00279-5 [pii] LID - 10.1016/j.appet.2026.108717 [doi] AB - The neighbourhood food environment is a potentially modifiable determinant of children's diets, yet evidence for associations with dietary outcomes remains mixed. This study examined cross-sectional associations between residential food environment characteristics and dietary outcomes among 8-year-old Dutch children, and whether maternal education (indicating household socioeconomic status) moderated these associations. Data were drawn from (n = 3739) children in the Generation R Study, a population-based birth cohort in Rotterdam, the Netherlands. Residential food environment exposure was assessed using Geographic Information System-based measures of absolute and relative fast-food outlet density and an overall neighbourhood food environment healthiness score within 400m from children's residences. Dietary outcomes were derived from a parent-reported Food Frequency Questionnaire, and included a validated overall diet quality score (out of 10), and non-core food and drink intake (g/day). Associations were examined using generalized linear models, adjusting for potential confounders. Findings revealed limited and unexpected associations. A healthier food environment score was associated with children's poorer diet quality, and no interaction with maternal education was found. Greater absolute fast-food outlet exposure was associated with better diet quality, but only among children with higher-educated mothers (+0.021 point/outlet, 95% CI: 0.008, 0.034). No associations were found between relative fast-food outlet density and any dietary outcomes. No consistent associations were found for food environment exposure and non-core food and drink intake. In the urban Dutch context, neighbourhood food environments showed weak and inconsistent associations with child diet, with some evidence of potential moderation by household socioeconomic status. These findings highlight the need for multidimensional research and intervention strategies that consider family resources and cultural context to effectively support healthy eating among children. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Harris, Holly A AU - Harris HA AD - Erasmus University Rotterdam, Department of Psychology, Education & Child Studies, Rotterdam, the Netherlands; Sydney Nursing School, Faculty of Medicine and Health, Discipline of Nutrition and Dietetics, The University of Sydney, Sydney, New South Wales, Australia; Charles Perkins Centre, The University of Sydney, Sydney, New South Wales, Australia. FAU - Molenberg, Famke J M AU - Molenberg FJM AD - Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands. FAU - Jansen, Wilma AU - Jansen W AD - Department of Public Health, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, the Netherlands; City of Rotterdam, Department of Social Development, Rotterdam, the Netherlands. FAU - Kocken, Paul AU - Kocken P AD - Erasmus University Rotterdam, Department of Psychology, Education & Child Studies, Rotterdam, the Netherlands. FAU - Voortman, Trudy AU - Voortman T AD - Department of Epidemiology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, the Netherlands. FAU - Jansen, Pauline W AU - Jansen PW AD - Erasmus University Rotterdam, Department of Psychology, Education & Child Studies, Rotterdam, the Netherlands; Department of Child & Adolescent Psychiatry/Psychology, Erasmus MC, University Medical Center, Rotterdam, the Netherlands; The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. Electronic address: p.w.jansen@erasmusmc.nl. LA - eng PT - Journal Article DEP - 20260710 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Netherlands MH - Child MH - Male MH - Cross-Sectional Studies MH - *Residence Characteristics MH - *Diet MH - *Neighborhood Characteristics MH - Fast Foods MH - Educational Status MH - Socioeconomic Factors MH - Surveys and Questionnaires MH - *Diet, Healthy MH - Geographic Information Systems MH - Mothers MH - *Food Supply MH - Feeding Behavior MH - Birth Cohort OTO - NOTNLM OT - Child OT - Diet quality OT - Fast-food exposure OT - Geographic information systems (GIS) OT - Neighbourhood food environment OT - Non-core food OT - Socioeconomic status COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/11 05:37 MHDA- 2026/09/07 23:34 CRDT- 2026/07/10 19:11 PHST- 2025/08/25 00:00 [received] PHST- 2026/06/22 00:00 [revised] PHST- 2026/07/09 00:00 [accepted] PHST- 2026/09/07 23:34 [medline] PHST- 2026/07/11 05:37 [pubmed] PHST- 2026/07/10 19:11 [entrez] AID - S0195-6663(26)00279-5 [pii] AID - 10.1016/j.appet.2026.108717 [doi] PST - ppublish SO - Appetite. 2026 Dec 1;227:108717. doi: 10.1016/j.appet.2026.108717. Epub 2026 Jul 10. PMID- 42430813 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1096-7206 (Electronic) IS - 1096-7192 (Linking) VI - 148 IP - 4 DP - 2026 Aug TI - Beyond citrulline: The diagnostic accuracy of amino acid ratios in neonatal intrahepatic cholestasis caused by citrin deficiency. PG - 110201 LID - S1096-7192(26)00484-1 [pii] LID - 10.1016/j.ymgme.2026.110201 [doi] AB - Neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD) is an autosomal recessive metabolic disorder resulting from biallelic pathogenic variants of the SLC25A13 gene. Because NICCD requires immediate and specific dietary management, which differs fundamentally from the treatment of idiopathic neonatal hepatitis (INH), rapid and noninvasive diagnostic tools are crucial. The aim of this study was to systematically evaluate the diagnostic accuracy of amino acid-derived metabolic ratios. This retrospective study analyzed 29 patients with genetically-confirmed NICCD who were evaluated at a single tertiary center between 2011 and 2026. To comprehensively evaluate diagnostic utility, a two-tiered receiver operating characteristic analysis was conducted comparing the NICCD cohort with both a total INH clinical cohort (n = 39) and a genetically-negative INH subgroup (n = 18). The diagnostic performance of amino acid-derived metabolic ratios was comparable to that of individual citrulline levels. The citrulline/alanine and citrulline/tryptophan ratios achieved favorable diagnostic accuracy, maintaining an area under the curve > 0.95, sensitivity > 85%, 100% specificity, and 100% positive predictive value across both control cohorts. The threonine/alanine ratio exceeded the established threonine/serine ratio. Genotype-phenotype analysis indicated that the c.852_855del variant was associated with abnormal newborn screening (p = 0.016), whereas the IVS16ins3kb variant consistently yielded normal results (p = 0.011). The citrulline/alanine, citrulline/tryptophan, and threonine/alanine ratios serve as highly accurate biomarkers that reflect and enhance the detection of the unique metabolic profile of NICCD. Integration of these indices into clinical protocols can reduce the time to diagnosis and facilitate prompt dietary and medical interventions. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Choi, Shinjie AU - Choi S AD - Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea. FAU - Choi, Naye AU - Choi N AD - Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea. FAU - Kim, Hwa Young AU - Kim HY AD - Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. FAU - Lee, Jisu AU - Lee J AD - Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea. FAU - Ko, Jae Sung AU - Ko JS AD - Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea. FAU - Ko, Jung Min AU - Ko JM AD - Department of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Pediatrics, Seoul National University Children's Hospital, Seoul, Republic of Korea; Rare Disease Center, Seoul National University Hospital, Seoul, Republic of Korea. Electronic address: jmko@snu.ac.kr. LA - eng PT - Journal Article DEP - 20260705 PL - United States TA - Mol Genet Metab JT - Molecular genetics and metabolism JID - 9805456 RN - 29VT07BGDA (Citrulline) RN - 0 (SLC25A13 protein, human) RN - 0 (Mitochondrial Membrane Transport Proteins) RN - 0 (Amino Acids) RN - 1340-08-5 (citrin) RN - 0 (Biomarkers) RN - 0 (Calcium-Binding Proteins) RN - 0 (Organic Anion Transporters) RN - Neonatal-onset citrullinemia type 2 SB - IM MH - Humans MH - *Citrullinemia/diagnosis/genetics/blood/complications MH - *Citrulline/blood/metabolism MH - Female MH - Infant, Newborn MH - Male MH - *Mitochondrial Membrane Transport Proteins/genetics MH - Retrospective Studies MH - *Cholestasis, Intrahepatic/diagnosis/blood/genetics MH - *Amino Acids/blood/metabolism MH - ROC Curve MH - Biomarkers/blood MH - Infant MH - Calcium-Binding Proteins MH - Organic Anion Transporters OTO - NOTNLM OT - Cholestasis, intrahepatic OT - Citrullinemia OT - Neonatal-onset citrullinemia type 2 OT - SLC25A13 protein, human COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/11 01:09 MHDA- 2026/07/16 16:06 CRDT- 2026/07/10 18:00 PHST- 2026/04/05 00:00 [received] PHST- 2026/05/28 00:00 [revised] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/07/16 16:06 [medline] PHST- 2026/07/11 01:09 [pubmed] PHST- 2026/07/10 18:00 [entrez] AID - S1096-7192(26)00484-1 [pii] AID - 10.1016/j.ymgme.2026.110201 [doi] PST - ppublish SO - Mol Genet Metab. 2026 Aug;148(4):110201. doi: 10.1016/j.ymgme.2026.110201. Epub 2026 Jul 5. PMID- 42430409 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Identification of a HOMA-IR cut-off point for cardiometabolic risk and modifiable risk factors in peruvian adolescents. PG - e0351139 LID - 10.1371/journal.pone.0351139 [doi] LID - e0351139 AB - BACKGROUND: Although HOMA-IR is widely used to assess insulin resistance, reported cut-off values vary substantially across population, particularly during adolescence. The aim of this study was to determine the distribution of HOMA-IR values. identify a HOMA-IR cut-off associated with metabolic syndrome (MS), and assess modifiable risk factors of IR in a longitudinal cohort of Peruvian adolescents. METHODS: We performed a secondary data analysis from a longitudinal adolescent's study. A sample of 371 adolescents (14.5 +/- 0.1 years old) from low- medium socioeconomic status. ROC curve analysis was used to identify the specific cut-off point to classify IR using the sensitivity and specificity values in comparison with the MS. Multiple logistic regression analysis including diet, physical activity and body composition from adolescence, excess weight during infancy and family history of non-chronic disease was included to identify risk factors (FHCD) associated with IR. RESULTS: The HOMA-IR was 3.29 (SD 1.71) with no differences by sex. We identified 3.9 for HOMA-IR as the cut-off point with sensitivity (72.4%) and specificity (75.4%) for predicting MS. IR was present in 28.6% (95% CI 24.2;33.4%); 84% had at least one cardiometabolic risk factor and low HDL and abdominal obesity were the most prevalent (62 and 35%, respectively). Adolescents with higher fat mass index (OR 16.03, 95% CI 6.79 to 37.86), and those physically inactive (OR 2.08 95% CI 1.06 to 4.07) were more likely to have IR. No association was found with diet, excess weight at infancy and FHCD. CONCLUSIONS: A cut-offs point of 3.9 for HOMA-IR allows to identify adolescents with high metabolic risk. Strategies to promote lower FMI and improve the physical activity levels could reduce the risk of IR in adolescents. CI - Copyright: (c) 2026 Curi-Quinto et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Curi-Quinto, Katherine AU - Curi-Quinto K AUID- ORCID: 0000-0002-2233-8251 AD - Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru. AD - Nutritional Research Institute, Lima, Peru. FAU - Vasquez, Fabian AU - Vasquez F AD - Finis Terrae University, Faculty of Medicine, School of Nutrition and Dietetic, Santiago, Chile. FAU - Abad, Melissa AU - Abad M AD - Nutritional Research Institute, Lima, Peru. FAU - Lazarte, Fabiola AU - Lazarte F AD - Nutritional Research Institute, Lima, Peru. FAU - Penny, Mary AU - Penny M AD - Nutritional Research Institute, Lima, Peru. FAU - Del Valle-Mendoza, Juana AU - Del Valle-Mendoza J AD - Research Center of the Faculty of Health Sciences, Universidad Peruana de Ciencias Aplicadas, Lima, Peru. AD - Nutritional Research Institute, Lima, Peru. LA - eng PT - Journal Article DEP - 20260710 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Peru/epidemiology MH - Female MH - Adolescent MH - *Insulin Resistance MH - Male MH - *Metabolic Syndrome/epidemiology MH - Risk Factors MH - *Cardiometabolic Risk Factors MH - Longitudinal Studies MH - ROC Curve PMC - PMC13354073 COIS- The authors declare that there are no conflicts of interest. EDAT- 2026/07/11 01:09 MHDA- 2026/07/11 01:10 PMCR- 2026/07/10 CRDT- 2026/07/10 13:53 PHST- 2025/03/06 00:00 [received] PHST- 2026/05/22 00:00 [accepted] PHST- 2026/07/11 01:10 [medline] PHST- 2026/07/11 01:09 [pubmed] PHST- 2026/07/10 13:53 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - PONE-D-25-02583 [pii] AID - 10.1371/journal.pone.0351139 [doi] PST - epublish SO - PLoS One. 2026 Jul 10;21(7):e0351139. doi: 10.1371/journal.pone.0351139. eCollection 2026. PMID- 42430046 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260904 IS - 1475-1313 (Electronic) IS - 0275-5408 (Linking) VI - 46 IP - 5 DP - 2026 Sep TI - Analysis of the Association Between Weight Status and Myopia in Children and Adolescents and Development of a Screening Model Based on Body Fat Percentage. PG - 1040-1048 LID - 10.1007/s44402-026-00135-y [doi] AB - PURPOSE: This study examined the association between weight status and myopia in children and adolescents and compared the screening performance of body mass index (BMI) and body fat percentage. METHODS: This cross-sectional study included 8748 students aged 7-15 years. Height, weight and body fat percentage were measured, and myopia was assessed using non-cycloplegic autorefraction. The sample was randomly divided into training and validation sets. Logistic regression adjusted for sex, age, residence, physical activity and outdoor light exposure was used to examine the association between weight status and myopia. Mediation analysis treated physical activity as a categorical variable, with bootstrap resampling used to test indirect effects through BMI and body fat percentage. Receiver operating characteristic curves compared the screening performance of both indicators. RESULTS: Overweight or obesity was associated with myopia after full adjustment (odds ratio = 1.45, 95% confidence interval: 1.30-1.63). Categorical mediation analysis showed a direct protective association of higher physical activity with myopia, with no significant indirect effect through BMI or body fat percentage. In both training and validation sets, the area under the curve was 0.76 for BMI and 0.76 for body fat percentage. A body fat percentage threshold of 0.69 classified a high-risk group with higher myopia prevalence than the low-risk group (88.7% versus 52.1%). CONCLUSION: Overweight or obesity is independently associated with myopia. BMI and body fat percentage provide comparable, low-cost tools for initial school-based risk stratification, while physical activity may protect against myopia independently of body composition. CI - (c) 2026. The Author(s), under exclusive licence to The College of Optometrists. FAU - Zhao, Deqiang AU - Zhao D AD - China Institute of Sport Science, Beijing, China. FAU - Chen, Xiaoxiao AU - Chen X AD - School of Physical Education and Sports Rehabilitation, Jinzhou Medical University, Jinzhou, China. FAU - Zhang, Aoyu AU - Zhang A AD - Tianshi College of Tianjin, School of Medicine, Tianjin, China. FAU - Pan, Xiang AU - Pan X AD - Graduate School of Health and Sports Science, Juntendo University, Inzai, Japan. FAU - Wang, Chunmiao AU - Wang C AD - China Institute of Sport Science, Beijing, China. FAU - Chen, Jiaxin AU - Chen J AD - China Institute of Sport Science, Beijing, China. FAU - Hu, Haixia AU - Hu H AD - Aiyoudong Children and Youth Sports Health Research Institute, Weifang, China. FAU - Zhang, Yanfeng AU - Zhang Y AD - China Institute of Sport Science, Beijing, China. zhangyanfeng0310@126.com. LA - eng GR - 2022YFC3600204/Special Project on "Scientific and Technological Countermeasures for Positive Health and Population Aging" under the National Key Research and Development Program of China/ GR - B2311/Weifang Integration of Sports and Health Innovation and Development Project/ GR - B2422/Weifang Children and Adolescents Sports-Health Integration Innovation and Development Initiative/ PT - Journal Article DEP - 20260710 PL - England TA - Ophthalmic Physiol Opt JT - Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) JID - 8208839 SB - IM MH - Humans MH - Child MH - Female MH - Adolescent MH - *Myopia/epidemiology/physiopathology/diagnosis/etiology MH - Cross-Sectional Studies MH - Male MH - Body Mass Index MH - *Adipose Tissue MH - ROC Curve MH - Risk Factors MH - *Overweight/complications MH - Prevalence MH - *Body Weight/physiology OTO - NOTNLM OT - Body fat percentage OT - Children and adolescents OT - Myopia OT - Overweight and obesity OT - ROC curve OT - Screening model COIS- Competing Interests: The authors declare no competing interests. Consent to Publish Declaration: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Institutional Review Board of the China Institute of Sport Science (Approval No. CISSLA20230110). Written informed consent was obtained from the guardians of all participating children and the children themselves provided assent. Ethics and Consent to Participate Declarations: All guardians of the subjects participating in the study have signed the informed consent form. Institutional Review Board statement: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Institutional Review Board of the Chinese Institute of Sport Science (No. CISSLA20230110). EDAT- 2026/07/10 12:44 MHDA- 2026/09/04 17:40 CRDT- 2026/07/10 11:20 PHST- 2025/12/18 00:00 [received] PHST- 2026/06/20 00:00 [accepted] PHST- 2026/06/18 00:00 [revised] PHST- 2026/09/04 17:40 [medline] PHST- 2026/07/10 12:44 [pubmed] PHST- 2026/07/10 11:20 [entrez] AID - 10.1007/s44402-026-00135-y [pii] AID - 10.1007/s44402-026-00135-y [doi] PST - ppublish SO - Ophthalmic Physiol Opt. 2026 Sep;46(5):1040-1048. doi: 10.1007/s44402-026-00135-y. Epub 2026 Jul 10. PMID- 42429973 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20261008 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 8 DP - 2026 Jul 10 TI - A multivariate electrocardiographic predictive model for left ventricular hypertrophy in children with primary hypertension. LID - 569 [pii] LID - 10.1007/s00431-026-07198-6 [doi] AB - Current electrocardiographic (ECG) criteria are of low diagnostic value compared with echocardiography (ECHO) for LVH, establishing a more effective ECG predictive model is required. The research purpose was to establish and validate a model to improve the diagnostic capability of ECG for LVH in pediatric primary hypertension. A retrospective study of 502 hypertensive children were recruited in the study between January 2019 and December 2024. The cohort were randomly divided into training (n = 402) and test sets (n = 100) with a proportion of 8:2. LVH was diagnosed using ECHO criteria. A total of 22 ECG parameters were evaluated. A predictive nomogram was developed using least absolute shrinkage and selection operator (LASSO) and multivariate logistic regression. LVH was identified in 117 (29.1%) of the training set and 29 (29.0%) of the test set. Body mass index (BMI), R(I) + S(V4), and S(D) + S(V4) were identified as independent predictors of LVH. The nomogram model showed good performance, with an area under the curve (AUC) of 0.822 in the training set and 0.803 in the test set. Calibration curves and Hosmer-Lemeshow test indicated good agreement between predicted and actual probabilities. DCA demonstrated clinical usefulness. The model outperformed previous models, as confirmed by NRI and IDI. CONCLUSIONS: The nomogram model incorporating BMI, R(I) + S(V4), and S(D) + S(V4) significantly improves the ECG diagnosis of LVH in pediatric primary hypertension, serving as a reliable tool for early LVH detection in hypertensive children. WHAT IS KNOWN: * We established a pediatric-specific nomogram integrating BMI and two composite ECG indices (R(I) + S(V4), S(D) + S(V4)); this model outperforms conventional adult ECG criteria and exhibits reliable discrimination, calibration and clinical practicability for diagnosing LVH in children with primary hypertension diagnosing LVH in children with primary hypertension. * This work innovatively uses BMI as a correction term to compensate for ECG voltage attenuation induced by chest wall fat in obese children, substantially lifting the overall ECG diagnostic accuracy of pediatric hypertensive LVH. WHAT IS NEW: * Our current study developed a nomogram model combining BMI, RI + SV4, and SD + SV4 that significantly improves ECG diagnostic accuracy for LVH in children with primary hypertension. * The research innovatively transforms BMI into a corrective factor addressing voltage attenuation caused by chest wall fat in obese children. * The model identifies pediatric-specific composite ECG indices superior to adult-derived criteria, demonstrating good discrimination, calibration, and clinical utility. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Liu, Yang AU - Liu Y AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Cui, Yaxi AU - Cui Y AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Lin, Yao AU - Lin Y AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Zheng, Tong AU - Zheng T AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Bao, Min AU - Bao M AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Liu, Yanyan AU - Liu Y AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Jiang, He AU - Jiang H AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. FAU - Shi, Lin AU - Shi L AUID- ORCID: 0000-0001-7578-7440 AD - Department of Cardiology, Capital Center for Children's Health, Capital Medical University, No. 2 Yabao Road, Chaoyang District, Beijing, 100020, China. shilin9789@126.com. LA - eng GR - YJRC202401/Research Start-up Fund for Introduced Talents of Capital Institute of Pediatrics/ GR - YGLX202532/Beijing Hospitals Authority Clinical medicine Development of special funding support/ GR - XZYB-2025-01/New Quality Fund of Capital Institute of Pediatrics/ PT - Journal Article DEP - 20260710 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Electrocardiography/methods MH - *Hypertrophy, Left Ventricular/diagnosis/etiology MH - Retrospective Studies MH - Child MH - *Nomograms MH - Female MH - Male MH - Predictive Value of Tests MH - *Essential Hypertension/complications MH - Adolescent MH - Multivariate Analysis MH - *Hypertension/complications MH - Echocardiography MH - Logistic Models OTO - NOTNLM OT - Children OT - Echocardiography OT - Electrocardiography OT - Hypertension OT - Left ventricular hypertrophy OT - Predictive model COIS- Declarations. Ethics approval: This study had approval from the Ethic Committee of the Capital Center for Children's Health, Capital Medical University (No: SHERLL2025011). Each child's parent or legal guardian/next of kin provided signed informed consent. This study was performed in line with the principles of the Declaration of Helsinki and its later amendments. Consent to participate: All participants gave their written consent to participate. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/10 12:46 MHDA- 2026/07/11 01:09 CRDT- 2026/07/10 11:15 PHST- 2026/03/19 00:00 [received] PHST- 2026/06/20 00:00 [accepted] PHST- 2026/05/29 00:00 [revised] PHST- 2026/07/11 01:09 [medline] PHST- 2026/07/10 12:46 [pubmed] PHST- 2026/07/10 11:15 [entrez] AID - 10.1007/s00431-026-07198-6 [pii] AID - 10.1007/s00431-026-07198-6 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jul 10;185(8):569. doi: 10.1007/s00431-026-07198-6. PMID- 42429723 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260826 IS - 2405-5018 (Electronic) IS - 2405-500X (Print) IS - 2405-500X (Linking) VI - 12 IP - 8 DP - 2026 Aug TI - Beta-Blockers and Exercise Performance in Children With Long QT Syndrome. PG - 2010-2018 LID - S2405-500X(26)00558-X [pii] LID - 10.1016/j.jacep.2026.06.010 [doi] AB - BACKGROUND: Young people taking beta-blockers for long QT syndrome (LQTS) have concerns about exercise performance. OBJECTIVES: This study sought to determine whether objective measures of cardiopulmonary fitness are influenced by beta-blocker dose in LQTS. METHODS: In a retrospective chart review of treadmill cardiopulmonary exercise tests (CPETs), we measured peak oxygen consumption (Vo(2)), respiratory exchange ratio (RER), blood pressure, and percent predicted heart rate at peak exertion (%PHR), each analyzed with a linear mixed-effects model. We analyzed nadolol data (noncardioselective) as our primary analysis, then analyzed a validation cohort of atenolol data (cardioselective). RESULTS: We evaluated 220 CPETs in 93 patients with LQTS. The mean age at first CPET was 12 +/- 3.9 years. In multivariable analysis, %PHR decreased by 13% for every 1 mg/kg/d increase in beta-blocker dose, demonstrating physiologic beta-blocker effects. However, we identified no correlation between nadolol dose and measures of cardiopulmonary fitness. Neither peak Vo(2) nor peak RER was correlated with nadolol dose. Only mild blood pressure changes were observed (<9 mm Hg decrease at peak exertion per 1 mg/kg increase in nadolol dose). Increased atenolol dose was also associated with stable peak Vo(2) and peak RER. CONCLUSIONS: In children with LQTS, we did not observe any relationship between higher nadolol doses and objective measures of effort (peak RER) or cardiopulmonary fitness (peak Vo(2)), despite a linear dose-response between nadolol dose and %PHR. These results suggest that treatment with nadolol for LQTS does not affect most patients' peak exercise performance. These data were validated in patients from an earlier era who had been prescribed atenolol. CI - Copyright (c) 2026 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved. FAU - Webster, Gregory AU - Webster G AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. Electronic address: rgwebster@luriechildrens.org. FAU - Gill, Nathan AU - Gill N AD - Division of Biostatistics and Informatics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Carberry, Thomas AU - Carberry T AD - Corewell Health Helen Devos Children's Hospital, Michigan State University College of Human Medicine, Grand Rapids, Michigan, USA. FAU - Chandler, Stephanie F AU - Chandler SF AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Cherny, Sara AU - Cherny S AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Lockhart, Elli N AU - Lockhart EN AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Onorato, Angela C AU - Onorato AC AD - The Heart Center, Nationwide Children's Hospital, Columbus, Ohio, USA. FAU - Dillenbeck, Halley AU - Dillenbeck H AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Ward, Kendra AU - Ward K AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Laternser, Christina AU - Laternser C AD - Division of Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. LA - eng GR - R01 HL164773/HL/NHLBI NIH HHS/United States GR - UL1 TR001422/TR/NCATS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260709 PL - United States TA - JACC Clin Electrophysiol JT - JACC. Clinical electrophysiology JID - 101656995 RN - 0 (Adrenergic beta-Antagonists) RN - 50VV3VW0TI (Atenolol) RN - 42200-33-9 (Nadolol) SB - IM MH - Humans MH - Child MH - *Long QT Syndrome/drug therapy/physiopathology MH - Exercise Test MH - *Adrenergic beta-Antagonists/therapeutic use/pharmacology MH - Female MH - Retrospective Studies MH - Adolescent MH - Male MH - Atenolol/therapeutic use MH - Heart Rate/drug effects MH - Oxygen Consumption/drug effects MH - Nadolol/therapeutic use/pharmacology MH - Blood Pressure/drug effects MH - *Exercise/physiology MH - Cardiorespiratory Fitness/physiology PMC - PMC13502152 MID - NIHMS2192871 OTO - NOTNLM OT - beta-adrenergic receptor antagonist OT - cardiopulmonary exercise test OT - electrophysiology OT - long QT syndrome OT - pediatric OT - pharmacology COIS- Funding Support and Author Disclosures The Northwestern University Clinical and Translational Sciences Institute is funded in part by a Clinical and Translational Science Award grant from the National Institutes of Health (UL1TR001422). This study was supported, in part, by the National Institutes of Health/National Heart, Lung, and Blood Institute (R01 HL164773) and philanthropic donors. Dr Webster has served as a consultant for Solid Biosciences. Dr Ward has served as a site principal investigator for a trial funded by Mezzion Pharmaceuticals. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. EDAT- 2026/07/10 12:46 MHDA- 2026/08/25 11:38 PMCR- 2026/08/25 CRDT- 2026/07/10 10:27 PHST- 2026/03/18 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/08/25 11:38 [medline] PHST- 2026/07/10 12:46 [pubmed] PHST- 2026/07/10 10:27 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - S2405-500X(26)00558-X [pii] AID - 10.1016/j.jacep.2026.06.010 [doi] PST - ppublish SO - JACC Clin Electrophysiol. 2026 Aug;12(8):2010-2018. doi: 10.1016/j.jacep.2026.06.010. Epub 2026 Jul 9. PMID- 42429700 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260821 IS - 1879-1972 (Electronic) IS - 1054-139X (Print) IS - 1054-139X (Linking) VI - 79 IP - 3 DP - 2026 Sep TI - Cultural Food Practices and Their Potential Role in Mitigating Disordered Eating Among American Indian/First Nations Youth. PG - 404-411 LID - S1054-139X(26)00191-6 [pii] LID - 10.1016/j.jadohealth.2026.05.006 [doi] AB - PURPOSE: Explore the relationship between disordered eating and engagement in cultural food practices in a sample of American Indian/First Nations (AI/FNs) adolescents. METHODS: Using interviewer-administered surveys data derived from Healing Pathways (N = 661), a longitudinal community-based participatory research study with Midwest AI/FN communities, we examined disordered eating, cultural food practices, and related sociodemographic variables in AI/FN adolescents using data from two time points/waves of this larger longitudinal study. We examined the structure of a disordered eating questionnaire using exploratory factor analysis to reveal psychometric properties of the questionnaire, resulting in three distinct disordered eating constructs "binge eating," "obsessive food behaviors," and "altered feelings about body." Associations with cultural food practices and these disordered eating constructs were examined using adjusted and unadjusted linear regression models. RESULTS: Greater engagement in cultural food practices was significantly associated with lower levels of "altered feelings about body" in both unadjusted (beta = -0.27, standard error [SE] = 0.04, p < .001) and adjusted models (beta = -0.11, SE = 0.05, p < .05). Identifying as female was linked to higher levels of both "obsessive food behaviors" (adjusted beta = 0.36, SE = 0.12, p < .05) and "altered feelings about body" (adjusted beta = 1.65, SE = 0.16, p < .001). DISCUSSION: Participation in cultural food practices may potentially play an important role in creating and sustaining healthy eating behaviors for AI/FN youth. Future research should consider the impact of disordered eating on nutrition-related health behaviors, as well as the potential protective role of cultural food practices against unhealthy eating behaviors. CI - Copyright (c) 2026 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved. FAU - Maudrie, Tara L AU - Maudrie TL AD - University of Michigan, School of Social Work, Ann Arbor, Michigan; Department of Health Behavior & Health Equity, University of Michigan, School of Public Health, Ann Arbor, Michigan. FAU - Gillson, Stefanie AU - Gillson S AD - Yale School of Medicine, Child Study Center, New Haven, Connecticut. FAU - Anderson, Olivia AU - Anderson O AD - Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland. FAU - Walls, Melissa L AU - Walls ML AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Center for Indigenous Health, Great Lakes Hub, Duluth, Minnesota. FAU - Steinberg, Rachel AU - Steinberg R AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Center for Indigenous Health, Great Lakes Hub, Duluth, Minnesota. FAU - Williams, Stephanie AU - Williams S AD - Healing Pathways, Community Research Council, Duluth, Minnesota. FAU - Hautala, Dane AU - Hautala D AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Center for Indigenous Health, Great Lakes Hub, Duluth, Minnesota. LA - eng GR - R01 DA039912/DA/NIDA NIH HHS/United States GR - U54 CA280805/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20260710 PL - United States TA - J Adolesc Health JT - The Journal of adolescent health : official publication of the Society for Adolescent Medicine JID - 9102136 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - Community-Based Participatory Research MH - *Feeding and Eating Disorders/ethnology/prevention & control/psychology MH - *Feeding Behavior/ethnology/psychology MH - *Indians, North American/psychology MH - Longitudinal Studies MH - Surveys and Questionnaires MH - *Indigenous Canadians/psychology PMC - PMC13488913 MID - NIHMS2201366 OTO - NOTNLM OT - AI/AN OT - Disordered eating OT - Food sovereignty OT - Indigenous OT - Nutrition OT - Traditional foods COIS- Conflicts of interest: The authors report no conflicts of interest. EDAT- 2026/07/10 12:45 MHDA- 2026/08/04 00:35 PMCR- 2026/08/19 CRDT- 2026/07/10 10:27 PHST- 2025/12/15 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/08/04 00:35 [medline] PHST- 2026/07/10 12:45 [pubmed] PHST- 2026/07/10 10:27 [entrez] PHST- 2026/08/19 00:00 [pmc-release] AID - S1054-139X(26)00191-6 [pii] AID - 10.1016/j.jadohealth.2026.05.006 [doi] PST - ppublish SO - J Adolesc Health. 2026 Sep;79(3):404-411. doi: 10.1016/j.jadohealth.2026.05.006. Epub 2026 Jul 10. PMID- 42428268 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260710 LR - 20260813 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 13 DP - 2026 TI - Association between triglyceride-glucose body mass index and risk of hypertensive disorders of pregnancy: a case-control study. PG - 1844562 LID - 10.3389/fmed.2026.1844562 [doi] LID - 1844562 AB - OBJECTIVE: To investigate the association between triglyceride-glucose body mass index (TyG-BMI) and the risk of hypertensive disorders of pregnancy (HDP), and to compare the discriminative ability of TyG-BMI with triglyceride-glucose index (TyG) and body mass index (BMI) for HDP. METHODS: A case-control study was conducted including 346 pregnant women hospitalized in the Department of Obstetrics at Fuyang Women and Children's Hospital from January 2021 to December 2025. Participants were divided into HDP group (n = 168) and control group (n = 178) based on HDP diagnosis. General clinical data, physical examinations, and hematological parameters at admission were collected for both groups. BMI, TyG index, and TyG-BMI were calculated. Multivariable logistic regression was used to analyze the independent association between TyG-BMI and HDP. Restricted cubic spline (RCS) curves were employed to explore dose-response relationships. Receiver operating characteristic (ROC) curves were used to compare the discriminative performance of different indices. RESULTS: The TyG-BMI level in the HDP group was significantly higher than that in the control group (228.4 +/- 44.6 vs. 196.8 +/- 36.2, P < 0.001). Multivariable logistic regression analysis showed that after adjusting for confounding factors, each 10-unit increase in TyG-BMI was associated with a 30% increase in HDP risk (adjusted OR = 1.30, 95%CI: 1.16-1.46, P < 0.001). RCS analysis demonstrated a non-linear positive association between TyG-BMI and HDP risk (P for non-linearity = 0.026). ROC analysis revealed that the area under the curve (AUC) for TyG-BMI in discriminating HDP was 0.782 (95%CI: 0.734-0.830), which was significantly superior to TyG index (AUC = 0.708, P = 0.005) and BMI (AUC = 0.694, P < 0.001). Subgroup analysis showed that the association between TyG-BMI and HDP remained consistent across all subgroups (all P for interaction > 0.05). CONCLUSION: TyG-BMI is independently and positively associated with HDP, and its discriminative performance is superior to TyG index and BMI. It can serve as a comprehensive indicator for identifying and assessing the degree of metabolic abnormalities in HDP patients. CI - Copyright (c) 2026 Liu, Ma, Chen and Chang. FAU - Liu, Jun AU - Liu J AD - Department of Obstetrics, Fuyang Women's and Children's Hospital, Fuyang, Anhui, China. FAU - Ma, Haoran AU - Ma H AD - Department of Respiratory and Critical Care Medicine, Fuyang Women's and Children's Hospital, Fuyang, Anhui, China. FAU - Chen, Xi AU - Chen X AD - Department of Ultrasound, Fuyang Women's and Children's Hospital, Fuyang, Anhui, China. FAU - Chang, Xueyun AU - Chang X AD - Department of Obstetrics, Fuyang Women's and Children's Hospital, Fuyang, Anhui, China. LA - eng PT - Journal Article DEP - 20260625 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC13346169 OTO - NOTNLM OT - case-control study OT - hypertensive disorders of pregnancy OT - insulin resistance OT - obesity OT - triglyceride-glucose body mass index COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/10 06:35 MHDA- 2026/07/10 06:36 PMCR- 2026/06/25 CRDT- 2026/07/10 05:15 PHST- 2026/04/01 00:00 [received] PHST- 2026/05/12 00:00 [revised] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/07/10 06:36 [medline] PHST- 2026/07/10 06:35 [pubmed] PHST- 2026/07/10 05:15 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.3389/fmed.2026.1844562 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Jun 25;13:1844562. doi: 10.3389/fmed.2026.1844562. eCollection 2026. PMID- 42427950 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260710 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - The association between social media use and dietary intake among adolescents in Turkiye: a cross sectional study. PG - 1862690 LID - 10.3389/fped.2026.1862690 [doi] LID - 1862690 AB - INTRODUCTION: Social media usage has surged up among adolescents and its relationship with dietary intake is unclear. This paper investigated the association between social media use and dietary intake among adolescents in Turkiye. METHODS: A cross sectional study was conducted. Convenience sampling was chosen. Private schools located in two cities in the Central and Eastern regions of Turkiye (Sanliurfa and Karaman). The sample consisted of 251 adolescents (13-18 years of age) and 49% of them were male. Dietary data were collected using a validated food frequency questionnaire. The multiple regression analysis adjusted for age groups were used to assess the relationship between social media use and dietary intake. Then Benjamini-Hochberg FDR correction was applied. All the data are based on beta (unstandardized) with standard error (SE) (beta+/-SE). RESULTS: Fewer than half of the participants reported using social media for over three hours daily (47.4%). The late adolescents used social media more than three hours a day (p < 0.05). Prolonged social media use (>3 h) was associated with higher energy (beta = 356.21 +/- 111.91 kcal, p = 0.002), carbohydrate (beta = 41.19 +/- 14.82 g, p = 0.006), sucrose (beta = 10.75 +/- 3.24 g, p = 0.001), fat (beta = 16.51 +/- 5.83 g, p = 0.005), calcium (beta= 146.44 +/- 54.72 mg, p = 0.008) and zinc (beta = 2.16 +/- 0.75 mg, p = 0.004) intake. Participants who were on social media for more than three hours a day consumed an average of 87.91 g more milk and yoghurt, 27.92 g more meat and processed meat, and 34.38 g more pastry than those who were on social media less than three hours a day. However after Benjamini-Hochberg False Discovery Rate correction, no relationship was found between dairy, meat and pastry consumption with social media duration (p > 0.05). Spending more time on social media was also related to more added sugar consumption (beta = 9.23 +/- 3.38 g, p = 0.007). CONCLUSIONS: The results indicate that prolonged use of social media is associated with higher energy, fat, sucrose, zinc and calcium consumption. These adolescents have a diet richer in micronutrients but also they follow a more obesogenic dietary pattern, which may be related to an increased risk of inflammatory and chronic diseases later in life. Longitudinal studies are needed to determine a causal relationship. CI - (c) 2026 Ozturk. FAU - Ozturk, Meryem Elif AU - Ozturk ME AD - Department of Nutrition and Dietetics, Karamanoglu Mehmetbey University, Karaman, Turkiye. LA - eng PT - Journal Article DEP - 20260625 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13345838 OTO - NOTNLM OT - adolescents OT - dietary intake OT - energy intake OT - social media OT - sucrose COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/10 06:34 MHDA- 2026/07/10 06:35 PMCR- 2026/06/25 CRDT- 2026/07/10 05:11 PHST- 2026/04/22 00:00 [received] PHST- 2026/06/03 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/07/10 06:35 [medline] PHST- 2026/07/10 06:34 [pubmed] PHST- 2026/07/10 05:11 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.3389/fped.2026.1862690 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 25;14:1862690. doi: 10.3389/fped.2026.1862690. eCollection 2026. PMID- 42427907 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260710 LR - 20260813 IS - 2038-9922 (Print) IS - 2038-9930 (Electronic) IS - 2038-9922 (Linking) VI - 17 IP - 1 DP - 2026 TI - Implementation of a Banana Flour Porridge Supplementation Initiative in a Mozambican Primary School: A pilot descriptive study. PG - 1749 LID - 10.4102/jphia.v17i1.1749 [doi] LID - 1749 AB - BACKGROUND: Child malnutrition remains a significant public health challenge in Mozambique, particularly in food-insecure rural communities. Locally available and culturally accepted foods may contribute to strengthening school feeding strategies. AIM: This pilot study described the nutritional status of schoolchildren in a Banana Flour Porridge Supplementation Initiative and assessed the feasibility of implementing and monitoring it in a public-school setting. SETTING: This study was conducted in a rural primary school in Ka Tembe District, Maputo Province, Mozambique. METHODS: A descriptive pilot study was conducted among 65 children aged 6-14 years. All participants received banana flour porridge daily for 30 days. Anthropometric measurements (weight, height, body mass index [BMI]) were collected at baseline, day 15 and day 30. A structured questionnaire assessed dietary habits. Data were analysed using descriptive statistics. RESULTS: At baseline, most children had adequate nutritional status, with low consumption of dairy and fortified foods, suggesting potential micronutrient gaps. During the 30-day supplementation period, the proportion of children classified as having an adequate BMI increased from 62.5% to 84.4% (aged 6-9 years) and from 57.6% to 87.9% (aged 10-14 years). These are descriptive observations. No adverse effects were reported. The initiative was easily integrated into the school routine and well accepted by students. CONCLUSION: Banana flour porridge supplementation is operationally feasible and acceptable in a school setting. Findings should be interpreted as preliminary and hypothesis-generating. CONTRIBUTION: This pilot provides early insights into the feasibility and acceptability of incorporating banana flour porridge into school feeding programmes. CI - (c) 2026. The Authors. FAU - Chidassicua, Jose Braz AU - Chidassicua JB AUID- ORCID: 0000-0001-5131-0349 AD - Collaborative Researchers' Team, Sergio Gago Foundation, Maputo, Mozambique. AD - Ministry of Health, National Institute of Health, Maputo, Mozambique. FAU - Titosse, Antonio AU - Titosse A AUID- ORCID: 0000-0001-6154-1933 AD - Collaborative Researchers' Team, Sergio Gago Foundation, Maputo, Mozambique. AD - Ministry of Health, Maputo, Mozambique. FAU - Magaco, Amilcar AU - Magaco A AUID- ORCID: 0000-0002-6381-4576 AD - Collaborative Researchers' Team, Sergio Gago Foundation, Maputo, Mozambique. FAU - Mondlane, Reginalda AU - Mondlane R AUID- ORCID: 0009-0008-0005-7740 AD - Collaborative Researchers' Team, Sergio Gago Foundation, Maputo, Mozambique. AD - Ministry of Health, Maputo, Mozambique. FAU - Mambuque, Edson AU - Mambuque E AUID- ORCID: 0000-0002-9106-1444 AD - Collaborative Researchers' Team, Sergio Gago Foundation, Maputo, Mozambique. AD - Manhica Health Research Center (CISM), Manhica, Mozambique. FAU - Goncalves, Maria Patricia AU - Goncalves MP AUID- ORCID: 0009-0002-5573-2842 AD - Collaborative Researchers' Team, Sergio Gago Foundation, Maputo, Mozambique. AD - Ministry of Health, National Institute of Health, Maputo, Mozambique. FAU - Cane, Reka Maulide AU - Cane RM AUID- ORCID: 0000-0001-8209-4976 AD - Collaborative Researchers' Team, Sergio Gago Foundation, Maputo, Mozambique. AD - Ministry of Health, National Institute of Health, Maputo, Mozambique. LA - eng PT - Journal Article DEP - 20260608 PL - South Africa TA - J Public Health Afr JT - Journal of public health in Africa JID - 101586943 PMC - PMC13347745 OTO - NOTNLM OT - Mozambique OT - child nutrition OT - food security OT - pilot study OT - school feeding OT - schoolchildren OT - sub-Saharan Africa COIS- The authors reported that they received funding from the Sergio Gago Foundation, which may be affected by the research reported in the enclosed publication. The authors have disclosed those interests fully and have implemented an approved plan for managing any potential conflicts arising from their involvement. The terms of these funding arrangements have been reviewed and approved by the affiliated institution in accordance with its policy on objectivity in research. EDAT- 2026/07/10 06:35 MHDA- 2026/07/10 06:36 PMCR- 2026/06/08 CRDT- 2026/07/10 05:11 PHST- 2025/11/03 00:00 [received] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/07/10 06:36 [medline] PHST- 2026/07/10 06:35 [pubmed] PHST- 2026/07/10 05:11 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - JPHIA-17-1749 [pii] AID - 10.4102/jphia.v17i1.1749 [doi] PST - epublish SO - J Public Health Afr. 2026 Jun 8;17(1):1749. doi: 10.4102/jphia.v17i1.1749. eCollection 2026. PMID- 42426960 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1365-2982 (Electronic) IS - 1350-1925 (Print) IS - 1350-1925 (Linking) VI - 38 IP - 7 DP - 2026 Jul TI - Transitioning Adolescents and Young Adults With Neurogastroenterology and Motility Disorders to Adult Care. Current Practices and Challenges in North America. PG - e70394 LID - 10.1111/nmo.70394 [doi] LID - e70394 AB - BACKGROUND: Pediatric neurogastroenterology and motility (NGM) disorders frequently persist into adulthood, yet there are no standardized transition of care (TOC) practices for this patient population. We characterized current TOC practices for adolescents and young adults with NGM disorders across North America. METHODS: A survey was distributed through listservs for North American pediatric gastroenterologists, registered dietitians, and advanced practice providers. The survey assessed institutional characteristics, TOC practices, team structure, handoff practices, barriers, and unmet needs. KEY RESULTS: Sixty-nine respondents from 40 unique medical centers completed the survey. Most practiced at academic medical centers (75.5%), with 66% having adult NGM providers at their institution. The majority transitioned patients at ages 18-19 years (44.1%) using patient interviews to assess readiness (61.8%), while only 2.9% used validated assessment tools. Most patients transferred to adult general gastroenterologists (76.5%) or adult NGM experts (64.7%). Infrastructure gaps were identified: 88.2% lacked transition coordinators, 91.3% had no formal transition teams, and no centers received financial support for transition services. Significant barriers reported were need for more adult NGM clinicians (60.3%) and patient hesitancy with transitioning care (58.3%). Respondents identified the greatest needs as more adult NGM clinicians, having dedicated transition coordinators, and formal transition protocols. CONCLUSIONS: This first national survey of NGM transition practices reveals gaps in infrastructure, workforce, and standardized protocols. Addressing these deficiencies requires coordinated efforts between pediatric and adult NGM communities and healthcare institutions to establish evidence-based practices that ensure continuity of care for this vulnerable patient population. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Wolfson, Sharon AU - Wolfson S AUID- ORCID: 0009-0001-9085-1022 AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. FAU - Santucci, Neha AU - Santucci N AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital, Cincinnati, Ohio, USA. AD - University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. FAU - Ambartsumayan, Lusine AU - Ambartsumayan L AD - Division of Pediatric Gastroenterology and Nutrition, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, Washington, USA. FAU - Patel, Dhiren AU - Patel D AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Cardinal Glennon Children's Hospital, Saint Louis University School of Medicine, St Louis, Missouri, USA. FAU - Khlevner, Julie AU - Khlevner J AUID- ORCID: 0000-0001-8166-0382 AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, Columbia University Vagelos College of Physicians and Surgeons, New York-Presbyterian Morgan Stanley Children's Hospital, New York, New York, USA. FAU - Saps, Miguel AU - Saps M AD - Division of Pediatric Gastroenterology, Hepatology and Nutrition, University of Miami, Miller School of Medicine, Miami, Florida, USA. LA - eng PT - Journal Article PL - England TA - Neurogastroenterol Motil JT - Neurogastroenterology and motility JID - 9432572 SB - IM MH - Humans MH - Adolescent MH - *Transition to Adult Care/standards MH - Young Adult MH - North America MH - Female MH - *Gastroenterology MH - Adult MH - *Gastrointestinal Diseases/therapy MH - Male MH - Surveys and Questionnaires PMC - PMC13350998 OTO - NOTNLM OT - DGBI OT - adolescents and young adults OT - neurogastroenterology and motility OT - transition of care COIS- The authors declare no conflicts of interest. EDAT- 2026/07/10 06:35 MHDA- 2026/07/10 13:18 PMCR- 2026/07/10 CRDT- 2026/07/10 00:33 PHST- 2026/05/27 00:00 [revised] PHST- 2026/03/04 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/10 13:18 [medline] PHST- 2026/07/10 06:35 [pubmed] PHST- 2026/07/10 00:33 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - NMO70394 [pii] AID - 10.1111/nmo.70394 [doi] PST - ppublish SO - Neurogastroenterol Motil. 2026 Jul;38(7):e70394. doi: 10.1111/nmo.70394. PMID- 42426319 OWN - NLM STAT- Publisher LR - 20260709 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jul 9 TI - Explainable machine learning integrating environmental chemical biomarkers and maternal clinical factors for prediction of hypertensive disorder of pregnancy. LID - 10.1038/s41598-026-61841-8 [doi] AB - Hypertensive disorders of pregnancy (HDP) represent a leading cause of maternal morbidity, yet environmental chemical contributors to HDP risk remain poorly characterized within predictive frameworks. We developed and evaluated an explainable machine-learning model integrating environmental biomarkers with maternal clinical characteristics for HDP prediction using data from 4,260 pregnant women enrolled in the Korean Children's Environmental Health Study (Ko-CHENS) prospective birth cohort. An Extreme Gradient Boosting (XGBoost) classifier incorporating 18 environmental biomarkers-including blood lead, cadmium, mercury, and endocrine-disrupting chemicals-alongside maternal clinical covariates was trained using stratified 60/20/20 data splits with Bayesian hyperparameter optimization. The optimized model achieved a cross-validated ROC-AUC of 0.787 and an independent test ROC-AUC of 0.748 (95% CI: 0.587-0.887), with a negative predictive value of 0.994 under severe class imbalance (HDP prevalence: 1.7%). SHapley Additive exPlanations (SHAP) analysis identified late-pregnancy blood lead concentration and pre-pregnancy body mass index as the dominant predictors, each exhibiting non-linear risk gradients; formal SHAP interaction values (1.6% of combined attribution) and an independent logistic-regression interaction term (beta = 0.418, 95% CI - 0.278-1.115, p = 0.239) indicated additive rather than synergistic BMI-lead pathways. These findings demonstrate that environmental biomarkers contribute independent, non-linear predictive value beyond established clinical risk factors, supporting integration of environmental exposure surveillance into precision obstetric risk stratification. CI - (c) 2026. The Author(s). FAU - Wang, Changwon AU - Wang C AD - Department of Integrated Healthcare Science, Soonchunhyang University, Asan, 31538, Republic of Korea. FAU - Lee, Jong-Dae AU - Lee JD AD - Department of Environmental Health Science, Soonchunhyang University, Asan, 31538, Republic of Korea. FAU - Kim, Ju Hee AU - Kim JH AD - Department of Nursing, College of Nursing Science, Kyung Hee University, Seoul, 02447, Republic of Korea. juheekim@khu.ac.kr. LA - eng GR - No. 5199990914048/BK21 FOUR (Fostering Outstanding Universities for Research/ PT - Journal Article DEP - 20260709 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM OTO - NOTNLM OT - Environmental chemical exposure OT - Explainable artificial intelligence OT - Hypertensive disorder of pregnancy OT - Machine learning COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/10 00:36 MHDA- 2026/07/10 00:36 CRDT- 2026/07/09 23:35 PHST- 2026/04/04 00:00 [received] PHST- 2026/07/07 00:00 [accepted] PHST- 2026/07/10 00:36 [medline] PHST- 2026/07/10 00:36 [pubmed] PHST- 2026/07/09 23:35 [entrez] AID - 10.1038/s41598-026-61841-8 [pii] AID - 10.1038/s41598-026-61841-8 [doi] PST - aheadofprint SO - Sci Rep. 2026 Jul 9. doi: 10.1038/s41598-026-61841-8. PMID- 42426095 OWN - NLM STAT- Publisher LR - 20260709 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jul 9 TI - Integrated framework for pediatric height assessment: X-ray-based height extreme cases classification and machine learning for multivariate height prediction. LID - 10.1038/s41598-026-56423-7 [doi] AB - Pediatric height assessment is crucial for evaluating growth and enabling timely intervention. However, traditional methods primarily assess current bone age rather than identifying future height abnormalities. This study proposes an integrated framework with two components: one uses hand X-ray images and clinical features to predict potential extreme height cases after one year; the other employs multivariate data to predict height across different time scales. To predict potential extreme cases, we employed fine-tuned Inception-ResNet-V2 as our classification model, while addressing class data imbalance through the DSEV method. For multivariate height prediction, we used XGBoost as our prediction model, incorporating various anthropometric and medical features, such as sex, age, body height, birth weight, medical diagnosis, and treatment. Results demonstrate that our classification models achieved outstanding performance in detecting unexpectedly short and unexpectedly tall cases, showing exceptional accuracy and reliability. Our multivariate prediction models demonstrated very low mean absolute error for predictions within 6 months, 1 year, 2 years, and near-final adult height, with consistent and stable performance. This integrated framework provides clinicians with more precise and comprehensive tools for evaluating children's growth and planning interventions. CI - (c) 2026. The Author(s). FAU - Chang, Ya-Wen AU - Chang YW AD - Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, 701, Taiwan ROC. FAU - Tsai, Meng-Che AU - Tsai MC AD - Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, Tainan, Taiwan ROC. mengchets@gs.ncku.edu.tw. FAU - Hsieh, Sun-Yuan AU - Hsieh SY AD - Department of Computer Science and Information Engineering, National Cheng Kung University, Tainan, 701, Taiwan ROC. hsiehsy@mail.ncku.edu.tw. AD - The Institute of Information Science, Academia Sinica, Taipei, 115201, Taiwan ROC. hsiehsy@mail.ncku.edu.tw. AD - The Research Center for Information Technology Innovation, Academia Sinica, Taipei, 115201, Taiwan ROC. hsiehsy@mail.ncku.edu.tw. AD - The Institute of Medical Informatics, National Cheng Kung University, Tainan, 701, Taiwan ROC. hsiehsy@mail.ncku.edu.tw. AD - Institute of Manufacturing Information and Systems, National Cheng Kung University, Tainan, 701, Taiwan ROC. hsiehsy@mail.ncku.edu.tw. LA - eng PT - Journal Article DEP - 20260709 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM OTO - NOTNLM OT - Artificial Intelligence OT - Bone Age OT - Deep Learning OT - Growth Abnormalities OT - Hand X-ray OT - Height Prediction OT - Machine Learning COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/10 00:35 MHDA- 2026/07/10 00:35 CRDT- 2026/07/09 23:26 PHST- 2025/11/22 00:00 [received] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/07/10 00:35 [medline] PHST- 2026/07/10 00:35 [pubmed] PHST- 2026/07/09 23:26 [entrez] AID - 10.1038/s41598-026-56423-7 [pii] AID - 10.1038/s41598-026-56423-7 [doi] PST - aheadofprint SO - Sci Rep. 2026 Jul 9. doi: 10.1038/s41598-026-56423-7. PMID- 42425539 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260731 IS - 1098-4275 (Electronic) IS - 0031-4005 (Linking) VI - 158 IP - 2 DP - 2026 Aug 1 TI - Portrayals of Food and Nutrition in Popular US Picture Books. LID - e2025074460 [pii] LID - 10.1542/peds.2025-074460 [doi] AB - BACKGROUND: Early experiences shape how children understand food as part of their health, family, and culture. Pediatricians promote picture book reading to support developmental and relational health. We conducted a pediatric-informed content analysis of food and nutrition in US picture books. METHODS: Using an interdisciplinary content analysis framework, we assessed food and nutrition content within a representative sample of US picture books (N = 159). Coders documented the presence and types of food, mealtimes, and social drivers of nutritional health. We assessed interrater reliability and summarized food-related content within the context of how the book depicted the role and function of food. RESULTS: The kappa agreement ranged from 78% to 99% (strong reliability). Most books depicted food in text (67%) or pictures (68%). Fruit (39%) was the most depicted food group, milk the most depicted beverage (15%), and sweet the most depicted flavor (33%). Among books that included meals, snacks were most common (57%), followed by dinner (41%). Characters ate with their families in over half (53%) of books that depicted meals. Food often symbolized a role beyond satiating hunger (eg, rewarding behavior, fostering connection). Specific roles were associated with a higher appearance of certain foods (eg, fruits with pleasure). CONCLUSIONS: Picture books, which frequently portray food and reliably capture children's interest, are helpful tools to engage children in conversations about the social, cultural, and nutritional functions of food. Our findings suggest that picture books are a commercial-free early literacy tool that can support integrated interventions addressing both nutritional and relational health. CI - Copyright (c) 2026 by the American Academy of Pediatrics. FAU - Duh-Leong, Carol AU - Duh-Leong C AD - Department of Pediatrics, NYU Grossman School of Medicine, New York, New York. FAU - Klass, Perri AU - Klass P AD - Department of Pediatrics, NYU Grossman School of Medicine, New York, New York. AD - Arthur L. Carter Journalism Institute, New York University, New York, New York. FAU - Nagpal, Nikita AU - Nagpal N AD - Department of Pediatrics, NYU Grossman School of Medicine, New York, New York. FAU - Palacio Mazo, Laura AU - Palacio Mazo L AD - Department of Pediatrics, NYU Grossman School of Medicine, New York, New York. FAU - Warda, Elise AU - Warda E AD - Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Tyson, Kendra AU - Tyson K AD - Constantine Georgiou Library and Resource Center for Children and Literature, NYU Steinhardt School of Culture, Education, and Human Development, New York, New York. FAU - Aristy, Claudia AU - Aristy C AD - Reach Out and Read, NYC Health + Hospitals Bellevue, New York, New York. FAU - Takahashi Oakland, Hannah AU - Takahashi Oakland H AD - Department of Medicine, Emory University School of Medicine, Atlanta, Georgia. FAU - Perrin, Eliana M AU - Perrin EM AD - Department of Pediatrics, Johns Hopkins University Schools of Medicine and Nursing, Baltimore, Maryland. LA - eng PT - Journal Article PL - United States TA - Pediatrics JT - Pediatrics JID - 0376422 SB - IM MH - Humans MH - United States MH - *Books MH - *Food MH - Child EDAT- 2026/07/10 00:35 MHDA- 2026/08/01 00:36 CRDT- 2026/07/09 20:04 PHST- 2025/09/24 00:00 [received] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/08/01 00:36 [medline] PHST- 2026/07/10 00:35 [pubmed] PHST- 2026/07/09 20:04 [entrez] AID - 208199 [pii] AID - 10.1542/peds.2025-074460 [doi] PST - ppublish SO - Pediatrics. 2026 Aug 1;158(2):e2025074460. doi: 10.1542/peds.2025-074460. PMID- 42425140 OWN - NLM STAT- Publisher LR - 20260813 IS - 1469-445X (Electronic) IS - 0958-0670 (Print) IS - 0958-0670 (Linking) DP - 2026 Jul 9 TI - Physiological evaluation of the Calgary adapted aRm ergometer (CARE) concussion exertion test in adolescent athletes: A repeated-measures observational study. LID - 10.1113/EP093264 [doi] AB - Exertion testing helps inform exercise prescription during concussion recovery. The Calgary Adapted aRm Ergometer (CARE) test, developed as the first upper-body specific exertion test, aims to improve accessibility and inclusivity in concussion care. While initial development was conducted in adults, its applicability in adolescents remains unknown. This study compared physiological responses between the CARE test and the Calgary Concussion Cycle Test (CCCT) in non-disabled adolescent male and female athletes. Fifteen females and fifteen males (aged 14-17) performed CARE and CCCT to volitional fatigue. Response differences, Bland-Altman plots, effect sizes, intraclass correlation and moderation by sex for heart rate (HR), middle cerebral artery velocity (MCAv), volume of oxygen consumption ( V̇O2 ), minute ventilation ( V̇E ) and end-tidal carbon dioxide ( PETCO2 ) were analysed at 25%, 50%, 75% and 100% of peak exertion levels. CARE elicited lower absolute values for HR, MCAv, PETCO2 , V̇O2 and V̇E compared to CCCT, with differences and 95% limits-of-agreement becoming more pronounced at higher intensities. For mild-to-moderate exercise (25-50% exertion), the range typically used in clinical concussion testing, HR and MCAv differences were small for both sexes. Near maximal intensity, the HR gap widened, but MCAv was comparable. Sex did not modify the relationship between tests for HR and MCAv. While CARE predominantly employs smaller muscle mass than CCCT, results showed robust and relatively comparable physiological responses between tests and between male and female adolescents. These findings further support CARE as an accessible and inclusive post-concussion exertion test for those not able to perform lower-body protocols. CI - (c) 2026 The Author(s). Experimental Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society. FAU - Burkart, Joshua J AU - Burkart JJ AUID- ORCID: 0009-0000-2142-7669 AD - Cerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. AD - Integrated Concussion Research Program, University of Calgary, Calgary, Alberta, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada. AD - Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada. FAU - Neill, Matthew G AU - Neill MG AUID- ORCID: 0009-0000-5397-208X AD - Cerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. AD - Integrated Concussion Research Program, University of Calgary, Calgary, Alberta, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada. AD - Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada. FAU - Galarneau, Jean-Michel AU - Galarneau JM AD - Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. FAU - Wilder, Tegan AU - Wilder T AD - Cerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. FAU - Johns, Sarah AU - Johns S AUID- ORCID: 0009-0007-8480-1014 AD - Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. FAU - Carere, Joseph AU - Carere J AD - Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. FAU - Leddy, John J AU - Leddy JJ AD - UBMD Department of Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, SUNY at Buffalo, Buffalo, New York, USA. FAU - Haider, Mohammad N AU - Haider MN AD - UBMD Department of Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, SUNY at Buffalo, Buffalo, New York, USA. FAU - Adams, William M AU - Adams WM AD - Adams Sports Medicine Consulting LLC, Colorado Springs, Colorado, USA. AD - Department of Kinesiology, University of North Carolina at Greensboro, Greensboro, North Carolina, USA. AD - School of Sport, Exercise and Health Sciences, National Centre for Sport and Exercise Medicine, Loughborough University, Loughborough, UK. AD - Department of Kinesiology, Michigan State University, East Lansing, Michigan, USA. FAU - Blauwet, Cheri AU - Blauwet C AD - Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation/Harvard Medical School, Boston, Massachusetts, USA. FAU - Debert, Chantel T AU - Debert CT AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. AD - Integrated Concussion Research Program, University of Calgary, Calgary, Alberta, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada. FAU - Emery, Carolyn A AU - Emery CA AD - Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. AD - Integrated Concussion Research Program, University of Calgary, Calgary, Alberta, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada. FAU - Smirl, Jonathan D AU - Smirl JD AD - Cerebrovascular Concussion Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Sport Injury Prevention Research Centre, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Human Performance Laboratory, Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, Alberta, Canada. AD - Integrated Concussion Research Program, University of Calgary, Calgary, Alberta, Canada. AD - Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Alberta, Canada. AD - Libin Cardiovascular Institute of Alberta, University of Calgary, Alberta, Canada. LA - eng GR - RGPIN-2020-04057/Natural Sciences and Engineering Research Council of Canada/ GR - CGSD3-559333-2021/Natural Sciences and Engineering Research Council of Canada/ GR - CAPMC/CIHR/Canada GR - University of Calgary, Faculty of Kinesiology/ GR - Foundation Brain Canada/ GR - Brain Changes Initiative/ GR - Branch Out Neurological Foundation/ GR - National Football League Play Smart Play Safe Program/ GR - Hotchkiss Brain Institute, University of Calgary/ PT - Journal Article DEP - 20260709 PL - England TA - Exp Physiol JT - Experimental physiology JID - 9002940 SB - IM PMC - PMC13394809 OTO - NOTNLM OT - adolescence OT - arm crank ergometry OT - exercise is medicine OT - exertion testing OT - sport-related concussion OT - transcranial doppler ultrasound COIS- None declared. EDAT- 2026/07/10 00:36 MHDA- 2026/07/10 00:36 PMCR- 2026/07/09 CRDT- 2026/07/09 18:53 PHST- 2025/08/31 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/10 00:36 [medline] PHST- 2026/07/10 00:36 [pubmed] PHST- 2026/07/09 18:53 [entrez] PHST- 2026/07/09 00:00 [pmc-release] AID - EPH70384 [pii] AID - 10.1113/EP093264 [doi] PST - aheadofprint SO - Exp Physiol. 2026 Jul 9:10.1113/EP093264. doi: 10.1113/EP093264. PMID- 42425048 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260904 IS - 1879-0046 (Electronic) IS - 0376-8716 (Linking) VI - 286 DP - 2026 Sep 1 TI - Youth's perception of parental limitation of youth screen time is associated with lower odds of nicotine vaping among US youth: Results from the 2024 National Survey on Drug Use and Health (NSDUH). PG - 113260 LID - S0376-8716(26)00241-3 [pii] LID - 10.1016/j.drugalcdep.2026.113260 [doi] AB - BACKGROUND: Youth media exposure is associated with vaping, while parental limitation of youth screen time may be associated with lower odds of youth vaping. Using nationally representative survey data, this study examines these relationships. METHODS: We used youth (aged 12-17) data from the 2024 National Survey on Drug Use and Health (N = 11,334) and defined past-month nicotine vaping as a binary variable (yes/no). Past-year youth's perception of parental limitation of youth screen time (television, tablets, smartphones, computers, and video games) was categorized as never, seldom, sometimes, or always. To estimate associations between youth's perception of parental limitation of screen time and past-month nicotine vaping, we conducted binomial logistic regression, controlling for relevant covariates. RESULTS: Overall, 5.5% of adolescents reported past-month nicotine vaping; 29.9% reported that parents never limited screen time, compared with 16.6% who reported always limiting screen time. In adjusted models, higher levels of youth's perception of screen time limitation were associated with lower odds of past-month nicotine vaping (AOR = 0.78, 95% CI = 0.66, 0.92). Several sensitivity analyses validated the findings. CONCLUSIONS: These findings identify that youth's perception of parental limitation of screen time was associated with lower odds of nicotine vaping among youth. Future studies should assess direct parental reports of restriction of youth screen time and examine comprehensive media-use approaches that combine screen-time limits in addition to general parenting practices. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Lee, Juhan AU - Lee J AD - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, United States; Department of Epidemiology and Population Health, Montefiore Einstein Comprehensive Cancer Center, United States. Electronic address: juhan.lee@einsteinmed.edu. FAU - Mattingly, Delvon T AU - Mattingly DT AD - Department of Behavioral Science, University of Kentucky College of Medicine, United States; Center for Health, Engagement, and Transformation, University of Kentucky College of Medicine, United States. LA - eng PT - Journal Article DEP - 20260704 PL - Ireland TA - Drug Alcohol Depend JT - Drug and alcohol dependence JID - 7513587 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Child MH - *Vaping/epidemiology/psychology MH - United States/epidemiology MH - *Screen Time MH - *Parents MH - Health Surveys MH - Media Exposure MH - *Perception OTO - NOTNLM OT - Media exposure OT - Nicotine vaping OT - Screen time OT - Youth COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/10 04:10 MHDA- 2026/09/04 23:36 CRDT- 2026/07/09 18:11 PHST- 2026/03/15 00:00 [received] PHST- 2026/06/06 00:00 [revised] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/09/04 23:36 [medline] PHST- 2026/07/10 04:10 [pubmed] PHST- 2026/07/09 18:11 [entrez] AID - S0376-8716(26)00241-3 [pii] AID - 10.1016/j.drugalcdep.2026.113260 [doi] PST - ppublish SO - Drug Alcohol Depend. 2026 Sep 1;286:113260. doi: 10.1016/j.drugalcdep.2026.113260. Epub 2026 Jul 4. PMID- 42425019 OWN - NLM STAT- MEDLINE DCOM- 20260822 LR - 20260919 IS - 1879-2219 (Electronic) IS - 0966-6362 (Linking) VI - 130 DP - 2026 Oct TI - Reliability and utility of a novel classification scheme for gait deviations in children with persistent idiopathic toe walking. PG - 110281 LID - S0966-6362(26)00191-8 [pii] LID - 10.1016/j.gaitpost.2026.110281 [doi] AB - BACKGROUND: Neurotypical children in whom toe walking does not resolve spontaneously by school age are considered to have Persistent Idiopathic Toe Walking (ITWp). The Alvarez classification, the only existing tool for classifying ITWp, is imprecise, and external validity has not been established. A comprehensive classification scheme based upon gait deviations in children with ITWp has been developed to facilitate clinical decision making and outcomes assessment. METHODS: A retrospective review was performed of subjects with ITWp, who were evaluated at a tertiary referral center by a standardized protocol including quantitative gait analysis. Sixty-five neurotypical children with ITWp were studied. Pre- and post-operative data were available for 26 of the 65 subjects (52 limbs). Cases were classified using the Alvarez classification and a novel Shriners Children's classification (SC-ITWp). Intra- and inter-observer reliability were determined for the SC-ITWp, as was utility (percentage classifiable) for both Alvarez and SC-ITWp (130 limbs, prior to intervention; 52 limbs following surgery to improve gait). RESULTS: The SC-ITWp exhibited excellent reliability, with intra-rater agreement of 96.7% (weighted kappa = 0.98); and inter-rater agreement of 86.7% (weighted kappa = 0.93). The Alvarez classification exhibited poor utility, failing to classify 59 of 130 limbs (45%) prior to intervention, and 23 of 52 limbs (44%) following surgery. The SC-ITWp exhibited excellent utility, successfully classifying each limb discretely into one category. CONCLUSIONS/SIGNIFICANCE: The SC-ITWp exhibited excellent reliability and utility in classifying the limbs of children with ITWp prior to interventions and following surgery to improve gait. LEVEL OF EVIDENCE: Diagnostic, level II. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Childers, Sancy AU - Childers S AD - Department of Pediatrics, University of Michigan School of Medicine, Ann Arbor, MI, USA. FAU - Brown, Sean AU - Brown S AD - Research and Movement Laboratory, MultiCare Mary Bridge Children's, Puyallup, WA, USA. FAU - Kephart, Don AU - Kephart D AD - Department of Orthopaedic Surgery, University of California School of Medicine, Sacramento, CA, USA. FAU - Bagley, Anita AU - Bagley A AD - Department of Orthopaedic Surgery, University of California School of Medicine, Sacramento, CA, USA; Department of Orthopaedic Surgery, Shriners Children's Northern California, Sacramento, CA, USA. FAU - Kulkarni, Vedant A AU - Kulkarni VA AD - Department of Orthopaedic Surgery, University of California School of Medicine, Sacramento, CA, USA; Department of Orthopaedic Surgery, Shriners Children's Northern California, Sacramento, CA, USA. FAU - Davids, Jon R AU - Davids JR AD - Department of Orthopaedic Surgery, University of California School of Medicine, Sacramento, CA, USA; Department of Orthopaedic Surgery, Shriners Children's Northern California, Sacramento, CA, USA. Electronic address: jdavids@shrinenet.org. LA - eng PT - Journal Article DEP - 20260708 PL - England TA - Gait Posture JT - Gait & posture JID - 9416830 SB - IM MH - Humans MH - Child MH - Retrospective Studies MH - Female MH - Reproducibility of Results MH - Male MH - *Gait Analysis/methods MH - *Toes/physiopathology MH - *Gait/physiology MH - *Gait Disorders, Neurologic/classification/physiopathology/diagnosis MH - Adolescent MH - Observer Variation OTO - NOTNLM OT - Classification OT - Gait analysis OT - Idiopathic toe walking COIS- Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Vedant Kulkarni reports a relationship with OrthoPediatrics Corp that includes: consulting or advisory. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/10 00:36 MHDA- 2026/08/22 23:43 CRDT- 2026/07/09 18:10 PHST- 2026/02/21 00:00 [received] PHST- 2026/06/07 00:00 [revised] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/08/22 23:43 [medline] PHST- 2026/07/10 00:36 [pubmed] PHST- 2026/07/09 18:10 [entrez] AID - S0966-6362(26)00191-8 [pii] AID - 10.1016/j.gaitpost.2026.110281 [doi] PST - ppublish SO - Gait Posture. 2026 Oct;130:110281. doi: 10.1016/j.gaitpost.2026.110281. Epub 2026 Jul 8. PMID- 42424543 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1751-7893 (Electronic) IS - 1751-7885 (Print) IS - 1751-7885 (Linking) VI - 20 IP - 7 DP - 2026 Jul TI - A Randomised Feasibility Trial of a Service-Coordinated Exercise Intervention in First-Episode Psychosis: Challenges in Implementation and Outcome Assessment. PG - e70193 LID - 10.1111/eip.70193 [doi] LID - e70193 AB - BACKGROUND: Psychosis is increasingly recognised as a systemic disorder characterised by interrelated metabolic dysfunction, chronic low-grade inflammation and sedentary lifestyles. Physical exercise is a promising intervention to address this triad. This pilot study investigated the feasibility and systemic impact of a pragmatic exercise intervention within a first-episode psychosis (FEP) service. METHODS: We conducted a parallel-group randomised controlled trial involving people with FEP, comparing an 8-week structured aerobic and resistance training programme to Treatment As Usual. We assessed feasibility of the intervention and assessments by measuring recruitment, attendance, retention, and engagement with assessments. Exploratory outcome measures spanned physical fitness, metabolic health, psychometric scales and the Cambridge Neuropsychological Test Automated Battery (CANTAB) cognitive battery. RESULTS: The study recruited 40 participants, 19 in the intervention and 21 in the control group. At baseline assessment, 23 of 38 had an elevated BMI and 24 of 35 had elevated cholesterol. Study retention was adequate, with only four participants (10%) lost to follow up. However, the assessment battery was poorly completed, highlighting its infeasibility. Fitness outcomes proved especially challenging, with between 11 and 13 participants (27.5% to 32.5%) completing both baseline and endpoint assessments. Of the 19 people recruited to the intervention arm, 7 (36.8%) attended less than half of the 8 sessions. Outcome data were limited by substantial missingness, with no consistent pattern of benefit or harm observed across domains. CONCLUSIONS: Implementing exercise within real-world FEP services is challenging as indicated by the attrition observed in our study. Future research should individualise exercise prescription and minimise participant assessment burden to mitigate attrition. CI - (c) 2026 The Author(s). Early Intervention in Psychiatry published by John Wiley & Sons Australia, Ltd. FAU - O'Mahony, Brian W AU - O'Mahony BW AUID- ORCID: 0000-0002-1530-0167 AD - UCD Centre for Psychosis Research, School of Medicine, University College Dublin, Dublin, Ireland. FAU - Wycherley, Elizabeth AU - Wycherley E AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. FAU - Daly, Karen AU - Daly K AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. FAU - Cowman, Meghan AU - Cowman M AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. FAU - Lonergan, Edgar AU - Lonergan E AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. FAU - Owens, Abigale AU - Owens A AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. FAU - O'Mahony, Karen AU - O'Mahony K AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. FAU - O'Donoghue, Brian AU - O'Donoghue B AUID- ORCID: 0000-0001-6240-6952 AD - UCD Centre for Psychosis Research, School of Medicine, University College Dublin, Dublin, Ireland. AD - Department of Psychiatry, St Vincent's University Hospital, Dublin, Ireland. FAU - Clarke, Gerard AU - Clarke G AUID- ORCID: 0000-0001-9771-3979 AD - Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland. AD - APC Microbiome Ireland, Biosciences Research Institute, University College Cork, Cork, Ireland. FAU - O'Connor, Karen AU - O'Connor K AUID- ORCID: 0000-0003-0696-8576 AD - RISE, Blackrock Hall Primary Care Centre, Cork, Ireland. AD - Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork, Ireland. LA - eng GR - ICAT-2022-001/HRBI_/Health Research Board/Ireland PT - Journal Article PT - Pragmatic Clinical Trial PT - Randomized Controlled Trial PL - Australia TA - Early Interv Psychiatry JT - Early intervention in psychiatry JID - 101320027 SB - IM MH - Humans MH - *Psychotic Disorders/therapy/psychology MH - Female MH - Feasibility Studies MH - Male MH - Adult MH - Pilot Projects MH - *Exercise Therapy/methods MH - Young Adult MH - *Outcome Assessment, Health Care MH - *Exercise MH - Adolescent PMC - PMC13349341 OTO - NOTNLM OT - attrition OT - exercise OT - feasibility OT - first-episode psychosis OT - metabolic health OT - physical health COIS- G.C. received honoraria from Janssen, Heel Pharmaceuticals, Probi, Boehringer Ingelheim and Apsen as an invited speaker; and research funding from Pharmavite, Reckitt, Tate and Lyle, Nestle and Fonterra. G.C. is or has been a paid consultant for Heel Pharmaceuticals, Bayer Healthcare, Yakult and Zentiva. All other authors declare no competing interests. EDAT- 2026/07/09 22:36 MHDA- 2026/07/10 12:45 PMCR- 2026/07/09 CRDT- 2026/07/09 15:23 PHST- 2026/06/05 00:00 [revised] PHST- 2026/05/01 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/07/10 12:45 [medline] PHST- 2026/07/09 22:36 [pubmed] PHST- 2026/07/09 15:23 [entrez] PHST- 2026/07/09 00:00 [pmc-release] AID - EIP70193 [pii] AID - 10.1111/eip.70193 [doi] PST - ppublish SO - Early Interv Psychiatry. 2026 Jul;20(7):e70193. doi: 10.1111/eip.70193. PMID- 42423735 OWN - NLM STAT- Publisher LR - 20260709 IS - 1432-0932 (Electronic) IS - 0940-6719 (Linking) DP - 2026 Jul 9 TI - Determining the minimal clinically important difference of angle of trunk rotation for monitoring conservatively treated adolescent idiopathic scoliosis. LID - 10.1007/s00586-026-10179-w [doi] AB - PURPOSE: The angle of trunk rotation (ATR) is widely used in the clinical follow-up of adolescent idiopathic scoliosis (AIS); however, the minimal clinically important difference (MCID) has not been clearly defined. This study aimed to determine treatment-specific MCID values for ATR in conservatively treated AIS patients. METHODS: This retrospective cohort study included 316 AIS patients treated with brace plus exercise or exercise alone. Radiographic outcomes at 6 months were classified as improvement (DeltaCobb /= + 5 degrees ). Receiver operating characteristic (ROC) analyses were performed to determine optimal DeltaATR cut-off values for clinically meaningful improvement and worsening in the overall cohort and separately by treatment group. RESULTS: In the overall cohort, DeltaATR showed good discriminative ability for improvement (AUC = 0.778) and worsening (AUC = 0.777). The optimal cut-offs were DeltaATR /= + 0.5 degrees for worsening. In subgroup analyses, the improvement threshold was DeltaATR /= + 0.5 degrees in the exercise-only group and >/= - 2.5 degrees in the brace-plus-exercise group. CONCLUSIONS: Treatment-specific DeltaATR thresholds provide clinically meaningful benchmarks for monitoring both improvement and worsening, supporting the use of ATR as a practical radiation-free follow-up parameter in AIS management. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Kuru Colak, Tugba AU - Kuru Colak T AUID- ORCID: 0000-0002-3263-2278 AD - Faculty of Health Science, Department of Physiotherapy and Rehabilitation, Marmara University, Istanbul, Turkey. cktugba@gmail.com. FAU - Akcay Genal, Burcin AU - Akcay Genal B AD - Faculty of Physical Therapy and Rehabilitation, Department of Prosthetics and Orthotics, Dokuz Eylul University, Izmir, Turkey. FAU - Colak, Ilker AU - Colak I AD - Faculty of Medicine, Department of Orthopaedics and Traumatology, Istinye University, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20260709 PL - Germany TA - Eur Spine J JT - European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society JID - 9301980 SB - IM OTO - NOTNLM OT - Adolescent idiopathic scoliosis OT - Angle of trunk rotation OT - Exercise therapy OT - Minimal clinically important difference OT - Orthotic devices OT - Scoliometer OT - Treatment outcome COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/09 12:33 MHDA- 2026/07/09 12:33 CRDT- 2026/07/09 11:05 PHST- 2026/02/25 00:00 [received] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/05/28 00:00 [revised] PHST- 2026/07/09 12:33 [medline] PHST- 2026/07/09 12:33 [pubmed] PHST- 2026/07/09 11:05 [entrez] AID - 10.1007/s00586-026-10179-w [pii] AID - 10.1007/s00586-026-10179-w [doi] PST - aheadofprint SO - Eur Spine J. 2026 Jul 9. doi: 10.1007/s00586-026-10179-w. PMID- 42423536 OWN - NLM STAT- MEDLINE DCOM- 20260928 LR - 20260929 IS - 2198-3844 (Electronic) IS - 2198-3844 (Linking) VI - 13 IP - 54 DP - 2026 Sep TI - Frequent Sweetened Beverage Consumption Is Associated With Accelerated Biological Aging: Evidence From a Population-Based Study and Gut Microbiota Analysis. PG - e76460 LID - 10.1002/advs.76460 [doi] LID - e76460 AB - Although substantial evidence links sweetened beverage (SB) intake to chronic diseases, its association with biological aging and underlying mechanisms remains unclear. This population-based study included 9104 adults aged 18-80 years from the WELL-China cohort. SB consumption was assessed using a validated food frequency questionnaire. Biological age and biological age acceleration (BAacc) were estimated using the Klemera and Doubal method (KDM). After multivariable adjustment, frequent SB consumption was significantly associated with accelerated KDM-derived BAacc, compared with non-consumers (beta = 0.29 years, 95% CI: 0.06-0.52). This association was stronger among participants younger than 55 years (P for interaction < 0.05). Gut microbiota was profiled using 16S rRNA gene sequencing. We identified 10 genera significantly associated with the frequent SB consumption, and 56 genera significantly associated with BAacc. Notably, five genera (Allisonella, Lactobacillus, Weissella, Lactococcus, and Bacilli_unclassified) were shared between the two analyses and enriched in both frequent SB consumers and individuals with higher BAacc. Frequent SB consumption is associated with accelerated biological aging, especially among adults younger than 55 years. Shared gut microbial signatures associated with both SB intake and BAacc suggest a potential microbiota-related pathway. These findings support reducing SB consumption as a potential strategy for promoting healthy aging. CI - (c) 2026 The Author(s). Advanced Science published by Wiley-VCH GmbH. FAU - Shi, Yuwei AU - Shi Y AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Li, Xinmei AU - Li X AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Hao, Yufan AU - Hao Y AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Wu, Qiaoyu AU - Wu Q AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Yu, Yuji AU - Yu Y AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Li, Siyu AU - Li S AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Xu, Nuo AU - Xu N AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Wu, Yi-Hsuan AU - Wu YH AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, California, USA. FAU - Lee, Eunhye AU - Lee E AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, California, USA. FAU - Chang, Chi AU - Chang C AD - Office of Medical Education Research and Development, College of Medicine, Michigan State University, East Lansing, Michigan, USA. FAU - Hu, Emily AU - Hu E AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, California, USA. FAU - Lu, Ying AU - Lu Y AUID- ORCID: 0000-0002-7698-8962 AD - Department of Biomedical Data Science, Stanford School of Medicine, Stanford University, Stanford, California, USA. FAU - Delzell, Elizabeth AU - Delzell E AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, California, USA. FAU - Hsing, Ann W AU - Hsing AW AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, California, USA. AD - Department of Epidemiology and Population Health, Stanford School of Medicine, Stanford University, Stanford, California, USA. AD - Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, California, USA. FAU - Zhu, Shankuan AU - Zhu S AUID- ORCID: 0000-0002-9509-7364 AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. LA - eng GR - China Medical Board (CMB)/ GR - 419600-11102/Cyrus Tang Foundation/ GR - 419600-11107/Chou Fund of Zhejiang University Education Foundation/ PT - Journal Article DEP - 20260709 PL - Germany TA - Adv Sci (Weinh) JT - Advanced science (Weinheim, Baden-Wurttemberg, Germany) JID - 101664569 RN - 0 (RNA, Ribosomal, 16S) SB - IM MH - Humans MH - *Gastrointestinal Microbiome/genetics/physiology MH - *Aging/physiology MH - Middle Aged MH - Adult MH - Aged MH - Female MH - Male MH - RNA, Ribosomal, 16S/genetics MH - China MH - Aged, 80 and over MH - Young Adult MH - *Sugar-Sweetened Beverages/adverse effects MH - Adolescent MH - Cohort Studies MH - *Beverages/adverse effects PMC - PMC13348652 OTO - NOTNLM OT - aging OT - biological age acceleration OT - gut microbiota OT - sweetened beverage COIS- The authors declare no conflicts of interest. EDAT- 2026/07/09 12:33 MHDA- 2026/09/28 11:38 PMCR- 2026/07/09 CRDT- 2026/07/09 10:23 PHST- 2026/06/13 00:00 [revised] PHST- 2026/01/20 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/09/28 11:38 [medline] PHST- 2026/07/09 12:33 [pubmed] PHST- 2026/07/09 10:23 [entrez] PHST- 2026/07/09 00:00 [pmc-release] AID - ADVS76460 [pii] AID - 10.1002/advs.76460 [doi] PST - ppublish SO - Adv Sci (Weinh). 2026 Sep;13(54):e76460. doi: 10.1002/advs.76460. Epub 2026 Jul 9. PMID- 42423249 OWN - NLM STAT- Publisher LR - 20260715 IS - 1469-7610 (Electronic) IS - 0021-9630 (Linking) DP - 2026 Jul 9 TI - The association between 24-hr movement patterns and self-harm incidence in adolescence. LID - 10.1111/jcpp.70199 [doi] AB - BACKGROUND: Self-harm is a pressing public health issue, particularly among adolescents. Physical activity is associated with reduced self-harm among youths, but evidence is limited. Most studies rely on self-reported measures and are primarily focused on moderate-to-vigorous physical activity (MVPA), often overlooking the role of light-intensity physical activity (LIPA). To address these gaps, we investigated the prospective associations between accelerometer-measured 24-hr movements and subsequent self-harm in adolescents. METHODS: This prospective cohort investigation analysed 2,016 children from the UK Millennium Cohort Study using data from the age 7 years survey (MCS4) when accelerometers were introduced (mean age = 7.23 years, SD = 0.25). Accelerometer-measured duration of MVPA, LIPA, sedentary behaviour (SB), and sleep were analysed. Self-harm behaviours were assessed via validated self-report questionnaires at ages 14 and 17 years, and subsequently, the associations examined using logistic and compositional data models. RESULTS: Among 2,016 participants (48.6% female), 548 self-harm cases occurred during 18,696 person-years of follow-up, with a median follow-up duration of 8.5 years (cumulative incidence = 27.2%). LIPA was inversely associated with self-harm (OR 0.76, 95% CI: 0.65-0.88). This association was stronger in compositional models (OR 0.23, 95% CI: 0.11-0.47). MVPA showed a significant non-linear, inverted U-shaped association with self-harm (p for non-linearity = .02). The risk peaked at approximately 1.2 hr/day and decreased substantially at levels exceeding 1.7 hr/day, while SB and sleep were not significantly associated with self-harm. Stratified analyses confirmed robustness. CONCLUSIONS: Our findings reveal a pronounced inverse association between LIPA and self-harm, along with a non-linear association for MVPA. These results support 24-hr movement guidelines that emphasise activity transitions over isolated targets and highlight LIPA's role in early prevention strategies. CI - (c) 2026 The Author(s). Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. FAU - Huang, Siyi AU - Huang S AUID- ORCID: 0000-0002-9461-2029 AD - Department of Infectious Diseases and Public Health, City University of Hong Kong, Hong Kong, China. AD - Department of Sports Science, College of Education, Zhejiang University, Hangzhou, China. FAU - Cui, Jiameng AU - Cui J AD - Department of Big Data in Health Science, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China. FAU - He, Qida AU - He Q AD - Department of Infectious Diseases and Public Health, City University of Hong Kong, Hong Kong, China. FAU - Ali, Shahmir H AU - Ali SH AD - Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore. FAU - Wang, Qi AU - Wang Q AD - Department of Data Science, City University of Hong Kong, Hong Kong, China. FAU - Thomas, G Neil AU - Thomas GN AD - Department of Applied Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UK. FAU - Li, Linyan AU - Li L AD - Department of Infectious Diseases and Public Health, City University of Hong Kong, Hong Kong, China. AD - Department of Data Science, City University of Hong Kong, Hong Kong, China. LA - eng GR - CityU21607223/Research Grants Council, University Grants Committee, Hong Kong/ GR - 7020097;7030008/City University of Hong Kong/ GR - City University of Hong Kong Institute of Digital Medicine/ PT - Journal Article DEP - 20260709 PL - England TA - J Child Psychol Psychiatry JT - Journal of child psychology and psychiatry, and allied disciplines JID - 0375361 SB - IM OTO - NOTNLM OT - Millennium Cohort Study OT - Non-suicidal self-harm OT - compositional data analysis OT - light-intensity physical activity OT - youth mental health EDAT- 2026/07/09 13:24 MHDA- 2026/07/09 13:24 CRDT- 2026/07/09 07:52 PHST- 2026/06/03 00:00 [accepted] PHST- 2026/07/09 13:24 [pubmed] PHST- 2026/07/09 13:24 [medline] PHST- 2026/07/09 07:52 [entrez] AID - 10.1111/jcpp.70199 [doi] PST - aheadofprint SO - J Child Psychol Psychiatry. 2026 Jul 9. doi: 10.1111/jcpp.70199. PMID- 42422709 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Prevalence and factors associated with adolescent idiopathic scoliosis in Shanghai, China: an artificial intelligence-assisted screening approach. PG - 1832421 LID - 10.3389/fpubh.2026.1832421 [doi] LID - 1832421 AB - OBJECTIVE: To investigate the prevalence of adolescent idiopathic scoliosis (AIS) and major modifiable factors associated with AIS among school students in Shanghai, China, and assess the feasibility and validated accuracy of AI-assisted 3D screening in school health management. METHODS: A multistage stratified cluster sampling design was employed in this cross-sectional study, conducted from July 2024 to June 2025. A structured-light 3D back-scanning AI system was used to screen 5,026 students aged 9-15 years from six schools in five districts of Shanghai. Physical fitness tests and questionnaires were used to collect data on body morphology, posture, physical activity, and lifestyle. Standing full-spine radiography was used as the reference standard for AIS diagnosis, defined as Cobb angle >/=10 degrees . Because radiographic verification was performed for all screen-positive students but only for a random subset of screen-negative students, inverse probability weighting was applied to account for partial verification. RESULTS: Among the 5,026 screened students, 160 AIS cases were confirmed among 185 rescreen-positive students, and 2 additional AIS cases were identified among 300 randomly verified screen-negative students. The crude radiographically confirmed detection rate was 3.2% (162/5,026), and the IPW-adjusted estimated population prevalence was 3.8%. Thoracic curves and Cobb angles of 10 degrees - < 20 degrees were most common. Girls and middle school students had higher crude radiographic detection rates than boys and primary school students, respectively. Multivariable binary logistic regression identified female sex, improper sitting posture among girls, very low post-exercise fatigue among boys, and frequent one-sided exertion sports as factors associated with screening-detected AIS, whereas higher BMI, balanced walking posture, and satisfactory sleep quality showed protective associations. The AI-assisted structured-light screening workflow showed IPW-adjusted sensitivity of 0.832, specificity of 0.995, PPV of 0.865, NPV of 0.993, and overall accuracy of 0.989. CONCLUSION: AIS represents a non-negligible spinal health burden among school students in Shanghai. Most factors associated with AIS are modifiable. The AI-assisted structured-light screening workflow demonstrated acceptable diagnostic accuracy and promising feasibility for large-scale school-based health screening and management integration. CI - Copyright (c) 2026 Cao, Li, Zhang, Gu, Zheng, Li, Liu, Feng, Yang, Zhang, Xie, Yu, Wu and Xia. FAU - Cao, Yuanyuan AU - Cao Y AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Li, Fangfang AU - Li F AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Zhang, Yong AU - Zhang Y AD - Education Bureau of Baoshan District, Shanghai, China. FAU - Gu, Wenwen AU - Gu W AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Zheng, Xinfeng AU - Zheng X AD - Department of Spine Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China. FAU - Li, Meng AU - Li M AD - Dongciyuan Intelligent Technology Co., Ltd., Shanghai, China. FAU - Liu, Xu AU - Liu X AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Feng, Mengjia AU - Feng M AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Yang, Xilin AU - Yang X AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Zhang, Yulu AU - Zhang Y AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Xie, Shu AU - Xie S AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Yu, Lijuan AU - Yu L AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Wu, Weibing AU - Wu W AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Xia, Jun AU - Xia J AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Scoliosis/epidemiology/diagnosis MH - Female MH - Male MH - China/epidemiology MH - Adolescent MH - Cross-Sectional Studies MH - Prevalence MH - Child MH - *Mass Screening/methods MH - *Artificial Intelligence MH - Risk Factors MH - Surveys and Questionnaires MH - Intelligent Systems PMC - PMC13344153 OTO - NOTNLM OT - 3D camera OT - AI-assisted screening OT - adolescent idiopathic scoliosis OT - machine learning OT - prevalence OT - risk factors COIS- ML was employed by Dongciyuan Intelligent Technology Co., Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/09 06:32 MHDA- 2026/07/09 06:33 PMCR- 2026/06/24 CRDT- 2026/07/09 04:46 PHST- 2026/03/17 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/07/09 06:33 [medline] PHST- 2026/07/09 06:32 [pubmed] PHST- 2026/07/09 04:46 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1832421 [doi] PST - epublish SO - Front Public Health. 2026 Jun 24;14:1832421. doi: 10.3389/fpubh.2026.1832421. eCollection 2026. PMID- 42422693 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Association between physical activity and mental health among Yi students aged 10-18 years in Southwest China: a school-based cross-sectional study. PG - 1878144 LID - 10.3389/fpubh.2026.1878144 [doi] LID - 1878144 AB - BACKGROUND: Physical activity is a modifiable behavior that may contribute to youth mental health, yet evidence from ethnic minority school populations in Southwest China remains limited. METHODS: This school-based cross-sectional study analyzed questionnaire data from 671 Yi students aged 10-18 years. Physical activity was assessed using an 8-item PAQ-like measure. Mental health was operationalized through three adverse domains: anxiety, loneliness, and social anxiety. Age, sex, and school stage were included as covariates. Psychometric performance was examined using Cronbach's alpha, the Kaiser-Meyer-Olkin statistic, and Bartlett's test of sphericity. Primary associations were estimated with ordinary least squares regression using HC3 robust standard errors, followed by sex- and stage-stratified models, PAQ tertile analyses, linear trend tests, strict complete-item sensitivity analyses, and exploratory parenting extension models. RESULTS: The final sample included 379 girls and 292 boys with a mean age of 13.87 years. Reliability was acceptable to excellent across the four core scales (alpha = 0.709-0.938), and factorability indices supported the use of scores in this sample. Physical activity was inversely correlated with loneliness (r = -0.114, p = 0.003), but not with anxiety or social anxiety. After adjustment, higher physical activity remained associated with lower loneliness (B = -2.13, 95% CI -3.40 to -0.85, p = 0.001), whereas associations with anxiety and social anxiety were not significant. Follow-up analyses showed that the inverse PAQ-loneliness association was more evident among boys and among upper primary and junior secondary students, and the loneliness gradient across PAQ tertiles was statistically significant. In exploratory contextual models, the PAQ coefficient attenuated after father- and mother-related parenting composites were added, while father support and father harsh control showed clear associations with loneliness. CONCLUSION: In this minority school sample, the mental health pattern associated with physical activity was selective rather than global. Higher physical activity was most consistently linked to lower loneliness, while its associations with anxiety and social anxiety were not robust. These findings support a more contextualized public health interpretation of youth physical activity, in which relational connectedness and family climate may shape psychological benefits. CI - Copyright (c) 2026 Shao, Zhang, Li and Wang. FAU - Shao, Qingju AU - Shao Q AD - School of Physical Education, Sichuan Normal University, Chengdu, China. FAU - Zhang, Xiaolin AU - Zhang X AD - School of Physical Education, Sichuan Normal University, Chengdu, China. FAU - Li, Xuefang AU - Li X AD - School of Marxism, Chongqing Normal University, Chongqing, China. FAU - Wang, Jiaheng AU - Wang J AD - School of Physical Education, Sichuan Normal University, Chengdu, China. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Male MH - Female MH - Cross-Sectional Studies MH - Adolescent MH - China/epidemiology MH - Child MH - *Mental Health/statistics & numerical data/ethnology MH - *Exercise/psychology MH - Loneliness/psychology MH - *Students/psychology/statistics & numerical data MH - Surveys and Questionnaires MH - Anxiety/epidemiology MH - Schools PMC - PMC13342181 OTO - NOTNLM OT - Yi students OT - loneliness OT - mental health OT - physical activity OT - school health OT - social anxiety COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/09 06:33 MHDA- 2026/07/09 06:34 PMCR- 2026/06/24 CRDT- 2026/07/09 04:46 PHST- 2026/05/11 00:00 [received] PHST- 2026/05/24 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/09 06:34 [medline] PHST- 2026/07/09 06:33 [pubmed] PHST- 2026/07/09 04:46 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1878144 [doi] PST - epublish SO - Front Public Health. 2026 Jun 24;14:1878144. doi: 10.3389/fpubh.2026.1878144. eCollection 2026. PMID- 42422684 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Physical activity, dietary habits, screen time, and sleep duration among Saudi male adolescent athletes and non-athletes: a cross-sectional study. PG - 1871762 LID - 10.3389/fpubh.2026.1871762 [doi] LID - 1871762 AB - BACKGROUND: Adolescence represents a pivotal stage for the development of lifelong health behaviors. In Saudi Arabia, rising obesity and sedentary lifestyles among youth represent growing public health challenges. While organized sports may positively influence lifestyle behaviors, evidence comparing Saudi adolescent athletes and non-athletes across multiple behavioral domains remains limited. PURPOSE: To compare lifestyle habits, including physical activity levels, sedentary behaviors, dietary practices, and sleep duration, between Saudi male adolescent athletes and non-athletes. METHOD: A cross-sectional study of 124 male high school students aged 16-17 years (70 athletes, 54 non-athletes) from Riyadh used a validated 47-item Arab Teen Lifestyle Study (ATLS) questionnaire. Physical activity was measured in METs-minutes per week. Chi-square tests, independent t-tests, and multiple linear regression were applied. RESULT: Athletes exhibited significantly higher physical activity levels (98.6% meeting guidelines compared to 55.6% of non-athletes; p < 0.001) and lower BMI (23.64 +/- 5.39 versus 29.69 +/- 8.34 kg/m(2); p < 0.001). Additionally, a greater proportion of athletes reported consuming fruit on five or more days per week (54.3% versus 33.3%; chi(2) = 8.10, p = 0.017; V = 0.26). Athletes reported shorter average sleep duration (9.06 +/- 3.67 versus 11.28 +/- 3.52 h per day; p = 0.001), although both groups exceeded the minimum recommended 8 h. No significant difference was observed between groups in daily screen time (4.04 +/- 2.63 versus 4.44 +/- 3.08 h; p = 0.44). In an exploratory regression model, frequency of energy drink consumption emerged as the only significant individual predictor of BMI (B = 4.12, 95% CI: 0.32-7.92; p = 0.034), although the overall model was not statistically significant (R (2) = 0.071; F = 1.26; p = 0.278). CONCLUSION: Participation in organized sports is linked to increased physical activity, lower body mass index, and improved fruit consumption among Saudi male adolescents. However, athletes reported reduced sleep duration, and elevated screen time persisted in both groups. These results support the integration of sports programs into adolescent health strategies and highlight the need for comprehensive interventions that address sleep hygiene, screen time management, and the promotion of physical activity. CI - Copyright (c) 2026 Bin Radhyan, Tomar, Bursais and Alaqil. FAU - Bin Radhyan, Fahad AU - Bin Radhyan F AD - Department of Physical Education, College of General Studies, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia. FAU - Tomar, Rakesh AU - Tomar R AD - Department of Physical Education, College of General Studies, King Fahd University of Petroleum and Minerals, Dhahran, Saudi Arabia. FAU - Bursais, Abdulmalek K AU - Bursais AK AD - Department of Physical Education, College of Education, King Faisal University, Al-Ahsa, Saudi Arabia. FAU - Alaqil, Abdulrahman I AU - Alaqil AI AD - Department of Physical Education, College of Education, King Faisal University, Al-Ahsa, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Male MH - Adolescent MH - Saudi Arabia MH - Cross-Sectional Studies MH - Sleep Duration MH - *Exercise MH - *Athletes/statistics & numerical data MH - *Feeding Behavior MH - *Screen Time MH - Surveys and Questionnaires MH - Sedentary Behavior MH - *Diet/statistics & numerical data MH - Life Style MH - Body Mass Index MH - *Sleep PMC - PMC13341710 OTO - NOTNLM OT - Saudi Arabia OT - adolescents OT - body mass index OT - dietary habits OT - physical activity OT - sedentary behavior OT - sleep duration COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/09 06:32 MHDA- 2026/07/09 06:33 PMCR- 2026/06/24 CRDT- 2026/07/09 04:46 PHST- 2026/05/03 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/05/30 00:00 [accepted] PHST- 2026/07/09 06:33 [medline] PHST- 2026/07/09 06:32 [pubmed] PHST- 2026/07/09 04:46 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1871762 [doi] PST - epublish SO - Front Public Health. 2026 Jun 24;14:1871762. doi: 10.3389/fpubh.2026.1871762. eCollection 2026. PMID- 42422420 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Sex differences in the predictive value of insulin resistance surrogate indicators for prediabetes among Chinese adults aged 18-45 years: a multicenter cohort study. PG - 1872088 LID - 10.3389/fendo.2026.1872088 [doi] LID - 1872088 AB - OBJECTIVE: The aim of this study was to evaluate and compare the predictive value of four insulin resistance (IR) surrogate indices for incident prediabetes and examine sex-specific disparities in their predictive performance. METHODS: This multicenter retrospective cohort study enrolled 63,795 adults aged 18-45 years (51.2% male) with normoglycemia at baseline from the Rich Healthcare Group Database (2010-2016). Participants were followed for a median of 2.97 years. Cox proportional hazards regression models, restricted cubic spline analyses, and receiver operating characteristic (ROC) curve analysis were employed to assess associations and discriminative performance. Statistical analyses were conducted using R software and EmpowerStats. RESULTS: During follow-up, 5,304 (8.31%) participants developed prediabetes, with a significantly higher incidence in men than in women (10.76% vs. 5.74%; p< 0.001). After multivariable adjustment, all four IR indices were independently associated with incident prediabetes. Sex-stratified analyses demonstrated markedly stronger associations in women, particularly for metabolic score for insulin resistance (METS-IR) [fully adjusted hazard ratio (HR): 7.82, 95% confidence interval (CI): 5.81-10.51 vs. 1.45, 95% CI: 1.18-1.77 in men]. Triglyceride-glucose-body mass index (TyG-BMI) demonstrated the highest predictive accuracy in the overall population [area under the curve (AUC) = 0.6497], and women exhibited superior discriminative performance across all indices compared to men. CONCLUSION: IR surrogate indices demonstrate significantly greater predictive value for prediabetes in young Chinese women than in men, with METS-IR exhibiting the most pronounced sex disparity. These findings support sex-specific risk stratification using routine IR surrogate indices in prediabetes screening. CI - Copyright (c) 2026 Chang, Zhang, UmarShinge, Gu, Zhou, Zhang, Zhang, Zhang, Liu and Yang. FAU - Chang, Yafei AU - Chang Y AD - Department of Cardiovascular Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China. FAU - Zhang, Luming AU - Zhang L AD - Department of Intensive Care Unit, The First Affiliated Hospital of Jinan University, Guangzhou, China. FAU - UmarShinge, Shafiu Adam AU - UmarShinge SA AD - Department of Cardiovascular Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China. FAU - Gu, Rui AU - Gu R AD - Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. FAU - Zhou, Xingchao AU - Zhou X AD - Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. FAU - Zhang, Qingzhou AU - Zhang Q AD - Department of Cardiovascular Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China. FAU - Zhang, Xinyi AU - Zhang X AD - Department of Cardiovascular Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China. FAU - Zhang, Binbin AU - Zhang B AD - Department of Cardiovascular Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China. FAU - Liu, Jiawei AU - Liu J AD - Department of Cardiovascular Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China. FAU - Yang, Yanqi AU - Yang Y AD - Department of Cardiovascular Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen, Guangdong, China. AD - Department of Cardiothoracic and Vascular Surgery, University Hospital, Linkoping University, Linkoping, Sweden. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260624 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) RN - Chinese people SB - IM MH - Humans MH - *Prediabetic State/epidemiology/diagnosis/metabolism MH - Female MH - *Insulin Resistance MH - Male MH - Adult MH - Retrospective Studies MH - China/epidemiology MH - Young Adult MH - Middle Aged MH - Adolescent MH - *Biomarkers MH - Predictive Value of Tests MH - Sex Factors MH - Follow-Up Studies MH - Blood Glucose/analysis MH - Incidence MH - Sex Characteristics MH - East Asian People PMC - PMC13341433 OTO - NOTNLM OT - Chinese population OT - METS-IR OT - TyG index OT - insulin resistance OT - sex differences COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/09 06:33 MHDA- 2026/07/09 06:34 PMCR- 2026/06/24 CRDT- 2026/07/09 04:42 PHST- 2026/05/04 00:00 [received] PHST- 2026/05/19 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/07/09 06:34 [medline] PHST- 2026/07/09 06:33 [pubmed] PHST- 2026/07/09 04:42 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.3389/fendo.2026.1872088 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Jun 24;17:1872088. doi: 10.3389/fendo.2026.1872088. eCollection 2026. PMID- 42421808 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260709 LR - 20260813 IS - 2468-4481 (Electronic) IS - 2468-4481 (Linking) VI - 11 IP - 7 DP - 2026 Jul TI - Endoscopic salvage for afferent loop syndrome: the antegrade lumen-apposing metal stent technique. PG - 298-303 LID - 10.1016/j.vgie.2026.01.007 [doi] AB - BACKGROUND AND AIMS: Afferent loop syndrome (ALS) is a rare postgastrectomy condition with biliopancreatic limb obstruction. Revision surgery carries high morbidity in patients with hostile anatomy. We aimed to demonstrate the feasibility of a double-scope, antegrade EUS-guided lumen-apposing metal stent (LAMS) enteroenterostomy as an endoscopic alternative in the management of complex ALS. METHODS: A patient with extensive prior gastric surgery presented with ALS. With a double-scope antegrade technique, a pediatric gastroscope (GIF-XP190 N; Olympus, Tokyo, Japan) was used to cannulate the afferent limb to place a guidewire, and a linear echoendoscope (GF-UCT180; Fujifilm, Tokyo, Japan) was advanced into the blind loop. The pediatric gastroscope was reintroduced into the efferent limb, which was water-distended to approximately 3 cm in diameter to achieve sonographic apposition. Under combined EUS and fluoroscopic guidance, a 15- x 15-mm electrocautery-enhanced LAMS (Boston Scientific, Marlborough, Mass, USA) was deployed to create an enteroenterostomy. RESULTS: Postdeployment contrast confirmed optimal position and immediate patency without leak. Symptoms resolved rapidly; the patient resumed a diet within days and gained weight. Abdominal radiography showed progressive LAMS expansion without adverse events. CONCLUSIONS: Double-scope antegrade EUS-guided LAMS placement safely decompressed the afferent limb in our patient, restoring enteral flow and avoiding high-morbidity reoperation. This technique merits consideration within multidisciplinary care and warrants larger comparative studies to define long-term outcomes. CI - (c) 2026 American Society for Gastrointestinal Endoscopy. Published by Elsevier Inc. FAU - Ang, Nicholas Ken Jin AU - Ang NKJ AD - Department of Upper Gastrointestinal and Bariatric Surgery, Singapore General Hospital, Singapore. FAU - Lim, Jie Qi AU - Lim JQ AD - Department of Upper Gastrointestinal and Bariatric Surgery, Singapore General Hospital, Singapore. FAU - Lye, Tiffany Jian Ying AU - Lye TJY AD - Department of Upper Gastrointestinal and Bariatric Surgery, Singapore General Hospital, Singapore. FAU - Tan, Damien Meng Yew AU - Tan DMY AD - Department of Gastroenterology and Hepatology, Singapore General Hospital, Singapore. FAU - Lim, Chin Hong AU - Lim CH AD - Department of Upper Gastrointestinal and Bariatric Surgery, Singapore General Hospital, Singapore. LA - eng PT - Journal Article DEP - 20260205 PL - United States TA - VideoGIE JT - VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy JID - 101719677 PMC - PMC13343362 COIS- All authors disclosed no financial relationships. EDAT- 2026/07/09 06:32 MHDA- 2026/07/09 06:33 PMCR- 2026/02/05 CRDT- 2026/07/09 04:35 PHST- 2025/09/24 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/07/09 06:33 [medline] PHST- 2026/07/09 06:32 [pubmed] PHST- 2026/07/09 04:35 [entrez] PHST- 2026/02/05 00:00 [pmc-release] AID - S2468-4481(26)00022-6 [pii] AID - 10.1016/j.vgie.2026.01.007 [doi] PST - epublish SO - VideoGIE. 2026 Feb 5;11(7):298-303. doi: 10.1016/j.vgie.2026.01.007. eCollection 2026 Jul. PMID- 42421701 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260709 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Health-related quality of life in children and adolescents with primary hypertension: a hospital-based cross-sectional study. PG - 1763465 LID - 10.3389/fpsyg.2026.1763465 [doi] LID - 1763465 AB - INTRODUCTION: Primary hypertension in childhood is increasingly recognized as an important health issue, but its impact on health-related quality of life (HRQoL) has not been well studied. METHODS: In this cross-sectional study conducted at the Pediatric Nephrology Department of Ege University Medical Center between June and December 2021, the Pediatric Quality of Life Inventory (PedsQL) 4.0 was administered face-to-face to 22 children and adolescents with primary hypertension and 31 healthy controls, along with their parents. Data were analyzed using IBM SPSS version 26. RESULTS: A total of 53 children and their parents were included. Compared with healthy controls, the primary hypertension group demonstrated significantly lower parent-reported physical health total scores, parent total PedsQL scores, and child physical health total scores. No statistically significant differences were observed between the groups in several other PedsQL subdomains. No significant differences were found in HRQoL scores according to BMI groups or treatment types. CONCLUSION: Children and adolescents with primary hypertension demonstrated lower health-related quality of life scores, particularly in physical health-related domains, compared with healthy controls. These findings suggest that primary hypertension may be associated with impaired quality of life in pediatric patients. Larger, multicenter, longitudinal studies are needed to validate these results. CI - Copyright (c) 2026 Topcak, Bulut Demir, Taner, Tosyali, Keskinoglu, Kabasakal and Kaplan Bulut. FAU - Topcak, Asli Berivan AU - Topcak AB AD - Department of General Pediatrics, Ege University Faculty of Medicine, Izmir, Turkiye. FAU - Bulut Demir, Melek Hande AU - Bulut Demir MH AD - Department of Child and Adolescent Psychiatry, Ministry of Health Dr. Behcet Uz Pediatric Diseases and Surgery Training and Research Hospital, Izmir, Turkiye. FAU - Taner, Sevgin AU - Taner S AD - Department of Pediatric Nephrology, Ege University Faculty of Medicine, Izmir, Turkiye. FAU - Tosyali, Merve AU - Tosyali M AD - Department of General Pediatrics, Ege University Faculty of Medicine, Izmir, Turkiye. FAU - Keskinoglu, Ahmet AU - Keskinoglu A AD - Department of Pediatric Nephrology, Ege University Faculty of Medicine, Izmir, Turkiye. FAU - Kabasakal, Caner AU - Kabasakal C AD - Department of Pediatric Nephrology, Ege University Faculty of Medicine, Izmir, Turkiye. FAU - Kaplan Bulut, Ipek AU - Kaplan Bulut I AD - Department of Pediatric Nephrology, Ege University Faculty of Medicine, Izmir, Turkiye. LA - eng PT - Journal Article DEP - 20260624 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13341690 OTO - NOTNLM OT - PedsQL OT - adolescents OT - children OT - hypertension OT - quality of life COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/09 10:11 MHDA- 2026/07/09 10:12 PMCR- 2026/06/24 CRDT- 2026/07/09 04:34 PHST- 2025/12/08 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/07/09 10:12 [medline] PHST- 2026/07/09 10:11 [pubmed] PHST- 2026/07/09 04:34 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1763465 [doi] PST - epublish SO - Front Psychol. 2026 Jun 24;17:1763465. doi: 10.3389/fpsyg.2026.1763465. eCollection 2026. PMID- 42421482 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260826 IS - 1839-2628 (Electronic) IS - 1832-4274 (Linking) VI - 29 IP - 3 DP - 2026 Jun TI - Discrepancies in Crown-Rump Length and Abnormal Cord Insertion as Predictors of Selective Fetal Growth Restriction in Monochorionic Twin Pregnancies. PG - 183-188 LID - 10.1017/thg.2026.10079 [doi] AB - This study aims to explore the significance of discrepancies in crown-rump length (CRL) and abnormal cord insertion in predicting selective fetal growth restriction (sFGR) in monochorionic (MC) twin pregnancies. Special attention was paid to determining the potential value of these factors in early pregnancy for predicting sFGR. A retrospective analysis included 131 pregnant women diagnosed with MC twin pregnancies. CRL was measured using a GE E8 color Doppler ultrasound instrument. Groups were compared based on the discrepancy in CRL (>/=6 mm difference group, n = 26; <6 mm normal group, n = 105) and the presence of abnormal cord insertion (abnormal group, n = 27; normal group, n = 104). The study found no significant association between CRL discrepancy and postnatal birth-weight discordance suggestive of sFGR (p > .05). In contrast, abnormal cord insertion was significantly associated with an increased occurrence of sFGR-related outcome (p < .001). Specifically, sFGR-related outcome occurred in 12 of 27 cases (44.4%) in the abnormal cord insertion group, compared with 7 of 104 cases (6.7%) in the normal cord insertion group. In this retrospective MC twin cohort, abnormal cord insertion was associated with an increased risk of postnatal birth-weight discordance suggestive of sFGR, whereas CRL discrepancy showed limited discriminative ability. Because of the retrospective design, limited number of outcome events, and use of postnatal rather than standardized antenatal Doppler-based sFGR criteria, these findings should be interpreted as exploratory and require validation in larger prospective studies. FAU - Luo, Jing AU - Luo J AD - Jiaxing Maternity and Child Health Care Hospital, China. FAU - Xu, Ping AU - Xu P AD - Jiaxing Maternity and Child Health Care Hospital, China. FAU - Ai, Lin AU - Ai L AD - Jiaxing Maternity and Child Health Care Hospital, China. FAU - Feng, Ying AU - Feng Y AUID- ORCID: 0009-0001-8508-0059 AD - Jiaxing Maternity and Child Health Care Hospital, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260709 PL - England TA - Twin Res Hum Genet JT - Twin research and human genetics : the official journal of the International Society for Twin Studies JID - 101244624 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Fetal Growth Retardation/diagnostic imaging MH - *Crown-Rump Length MH - *Pregnancy, Twin MH - *Umbilical Cord/diagnostic imaging/abnormalities MH - Retrospective Studies MH - Ultrasonography, Prenatal MH - *Twins, Monozygotic MH - Adult MH - Birth Weight MH - Infant, Newborn OTO - NOTNLM OT - Abnormal cord insertion OT - Crown-Rump Length discrepancy OT - Early pregnancy prediction OT - Monochorionic twins OT - Selective Fetal Growth Restriction EDAT- 2026/07/09 06:32 MHDA- 2026/08/06 12:37 CRDT- 2026/07/09 03:23 PHST- 2026/08/06 12:37 [medline] PHST- 2026/07/09 06:32 [pubmed] PHST- 2026/07/09 03:23 [entrez] AID - S1832427426100796 [pii] AID - 10.1017/thg.2026.10079 [doi] PST - ppublish SO - Twin Res Hum Genet. 2026 Jun;29(3):183-188. doi: 10.1017/thg.2026.10079. Epub 2026 Jul 9. PMID- 42421336 OWN - NLM STAT- Publisher LR - 20260727 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) DP - 2026 Jul 9 TI - Dietary inflammation during pregnancy and later symptoms of offspring behavioural and emotional problems. PG - 1-10 LID - 10.1017/S0007114526107879 [doi] AB - The maternal diet is believed to influence child neurodevelopment, at least in part, through inflammation, as dietary components can have pro- or anti-inflammatory effects. We examined the association between the energy-adjusted dietary inflammatory index (E-DII) during pregnancy and offspring symptoms of behavioural and emotional problems at 5.5 and 10 years, using data from the French nationwide Etude Longitudinale Francaise depuis l'Enfance/French Longitudinal Study since Childhood (ELFE) birth cohort. Dietary intake during pregnancy was assessed using a validated FFQ, and an E-DII score was generated. Child behavioural and emotional symptoms, including hyperactivity-inattention, conduct, peer-relationship and emotional problems, were evaluated by parents using the Strengths and Difficulties Questionnaire at 5.5 (n 9627) and 10 years (n 8362) for hyperactivity-inattention, conduct, peer-relationship and emotional problems. Children were classified into three categories based on thresholds used to identify clinically relevant symptoms: 'Normal', 'Borderline' and 'Atypical'. Multinomial logistic regression adjusted for potential confounders was used to estimate OR and 95 % CI. An increasing maternal E-DII score during pregnancy was associated with higher odds of offspring classified with atypical hyperactivity-inattention and conduct problem scores at 5.5 and 10 years, atypical peer-relationship problem scores at 10 years and atypical emotional problem scores at 10 years (differentially by sex). A more pro-inflammatory diet during pregnancy was consistently associated with higher odds of symptoms of externalising problems throughout childhood and with internalising problems at 10 years. Future research should explore the mechanisms by which prenatal exposure to maternal diet-induced inflammation may contribute to these outcomes. FAU - Dow, Courtney AU - Dow C AUID- ORCID: 0000-0002-9925-8460 AD - Universite Paris Cite and Universite Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Paris, F-75004, France. ROR: https://ror.org/05f82e368 FAU - Delvert, Rosalie AU - Delvert R AUID- ORCID: 0000-0002-1524-8071 AD - Universite Paris-Saclay, UVSQ, Univ. Paris-Sud, Inserm, Equipe d'Epidemiologie respiratorie integrative, CSEP, Villejuif, France. FAU - de Lauzon-Guillain, Blandine AU - de Lauzon-Guillain B AUID- ORCID: 0000-0001-5887-8842 AD - Universite Paris Cite and Universite Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Paris, F-75004, France. ROR: https://ror.org/05f82e368 FAU - van der Waerden, Judith AU - van der Waerden J AD - Sorbonne Universite, Inserm, Institut Pierre Louis d'Epidemiologie et de Sante Publique (IPLESP), Equipe de Recherche en Epidemiologie Sociale (ERES), Paris, 75012, France. FAU - Davidovic, Laetitia AU - Davidovic L AD - Universite Cote d'Azur, CNRS UMR7275, Inserm U1323, Institut de Pharmacologie Molecularie et Cellulaire, Valbonne, France. FAU - Charles, Marie-Aline AU - Charles MA AD - Universite Paris Cite and Universite Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Paris, F-75004, France. ROR: https://ror.org/05f82e368 FAU - Galera, Cedric AU - Galera C AD - University of Bordeaux, Inserm, Bordeaux Population Health Center, UMR 1219, Bordeaux, France. AD - Centre Hospitalier Charles Perrens, Bordeaux, France. AD - Unit on Children's Psychosocial Maladjustment, Montreal, Canada. FAU - Heude, Barbara AU - Heude B AD - Universite Paris Cite and Universite Sorbonne Paris Nord, Inserm, INRAE, Centre for Research in Epidemiology and Statistics (CRESS), Paris, F-75004, France. ROR: https://ror.org/05f82e368 LA - eng PT - Journal Article DEP - 20260709 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM OTO - NOTNLM OT - Behavioural problems OT - Dietary inflammatory index OT - Inflammation OT - Life course OT - Pregnancy OT - Prenatal environment EDAT- 2026/07/09 06:33 MHDA- 2026/07/09 06:33 CRDT- 2026/07/09 01:43 PHST- 2026/07/09 06:33 [pubmed] PHST- 2026/07/09 06:33 [medline] PHST- 2026/07/09 01:43 [entrez] AID - S0007114526107879 [pii] AID - 10.1017/S0007114526107879 [doi] PST - aheadofprint SO - Br J Nutr. 2026 Jul 9:1-10. doi: 10.1017/S0007114526107879. PMID- 42420938 OWN - NLM STAT- MEDLINE DCOM- 20261006 LR - 20261008 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 8 TI - Reproducibility of an 85-item Child Food Frequency Questionnaire (85-item Child-FFQ) and diet quality scores among Polish children: The cross-sectional PITNUTS 2024 study. LID - 10.1186/s12887-026-07222-6 [doi] LID - 949 AB - BACKGROUND: Early childhood nutrition is crucial for long-term health; however, assessing dietary intake in young children is challenging due to the reliance on parent/caregiver reporting and the need for culturally relevant tools. The aim of this study (the Polish Infant and Toddler Nutrition Study, PITNUTS 2024) was to address this gap by developing and evaluating the reproducibility of a new 85-item Child Food Frequency Questionnaire (85-item Child-FFQ) and associated diet quality scores for Polish children aged 13-72 months. METHODS: A cross-sectional, nationally representative sample of 700 Polish children from two age groups (13-36 and 37-72 months) was recruited, and 100 children were randomly selected from each age group for the reproducibility study. The 85-item Child-FFQ was administered twice to the same parent as a proxy reporter. Three diet quality scores were developed: the children's pro-Healthy Diet Score, the children's non-Healthy Diet Score, the children's Ultra-Processed Food Score. Statistical analyses included comparisons of mean values for food consumption frequency and diet quality scores, cross-classification, kappa statistic, intraclass correlation coefficient (ICC), Spearman's correlation, and Bland-Altman plots. RESULTS: The 85-item Child-FFQ showed good test-retest reproducibility. Classification agreement for food consumption frequency ranged from 74% to 97% for children aged 13-36 months, and 77% to 95% for children aged 37-72 months. The kappa statistic indicated moderate to excellent agreement between test and retest of the FFQ. Diet quality scores demonstrated high reproducibility, with classification agreement ranging from 77% to 92%, the kappa statistic ranging from 0.62 to 0.86, and good to excellent correlation coefficients (ICC: 0.886-0.950, Spearman's r: 0.889-0.947). The Bland-Altman analysis revealed a small negative shift between test and retest of the diet quality scores and moderately wide limits of agreement. CONCLUSIONS: The newly developed 85-item Child-FFQ is a reliable tool for assessing habitual food consumption frequency and diet quality in Polish children aged 13-72 months. This tool has the potential to help monitor food consumption and diet quality variations over time, though this capacity needs to be validated through future longitudinal studies. TRIAL REGISTRATION: This trial was registered at www. CLINICALTRIALS: gov (NCT06417151, 16th May 2024). CI - (c) 2026. The Author(s). FAU - Sawicki, Michal AU - Sawicki M AD - Nutricia Foundation, 8 Bobrowiecka Street, Warsaw, 00-728, Poland. FAU - Kowalkowska, Joanna AU - Kowalkowska J AD - Department of Human Nutrition, Faculty of Food Science, University of Warmia and Mazury in Olsztyn, 45F Sloneczna Street, Olsztyn, 10-718, Poland. joanna.kowalkowska@uwm.edu.pl. FAU - Weker, Halina AU - Weker H AD - Department of Nutrition, Institute of Mother and Child, 17a Kasprzaka Street, Warsaw, 01-211, Poland. FAU - Wadolowska, Lidia AU - Wadolowska L AD - Department of Human Nutrition, Faculty of Food Science, University of Warmia and Mazury in Olsztyn, 45F Sloneczna Street, Olsztyn, 10-718, Poland. LA - eng SI - ClinicalTrials.gov/NCT06417151 GR - RG 1/2023/Nutricia Foundation/ PT - Journal Article PT - Observational Study DEP - 20260708 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Cross-Sectional Studies MH - *Diet MH - *Diet Surveys/methods MH - *Feeding Behavior MH - Poland MH - Reproducibility of Results MH - Surveys and Questionnaires PMC - PMC13640158 OTO - NOTNLM OT - Diet quality OT - Dietary assessment OT - Dietary pattern OT - Food frequency questionnaire OT - Nutrition OT - Preschoolers OT - Reliability OT - Reproducibility OT - Toddlers OT - Ultra-processed food COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethics Committee of the Institute of Mother and Child in Warsaw (ethics approval number: 40/2024). Informed consent was obtained from all parents-proxies involved in the study. Consent for publication: Not applicable. Competing interests: MS is an employee of the Nutricia Foundation that sponsored this study. EDAT- 2026/07/09 06:32 MHDA- 2026/10/06 05:29 PMCR- 2026/07/08 CRDT- 2026/07/09 00:19 PHST- 2026/02/27 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/10/06 05:29 [medline] PHST- 2026/07/09 06:32 [pubmed] PHST- 2026/07/09 00:19 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - 10.1186/s12887-026-07222-6 [pii] AID - 7222 [pii] AID - 10.1186/s12887-026-07222-6 [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 8;26(1):949. doi: 10.1186/s12887-026-07222-6. PMID- 42420921 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261010 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jul 9 TI - Effectiveness and implementation of an intervention strategy-based health promoting schools framework to reduce idiopathic scoliosis and myopia among children and adolescents in Shanghai, China: study protocol. LID - 10.1186/s12889-026-28184-5 [doi] LID - 2865 AB - BACKGROUND: Idiopathic scoliosis (IS) and myopia have emerged as major public health concerns affecting children and adolescents worldwide, with a confirmed comorbid association. Both conditions share common risk factors, including outdoor activity, sedentary behaviour, screen time, and sleep duration. This protocol describes a study designed to evaluate the effectiveness of the "ATPISM" intervention strategy, which is developed based on the six core characteristics of the Health Promoting School (HPS) framework advocated by the World Health Organization (WHO). Appropriate Techniques for the Prevention of Idiopathic Scoliosis and Myopia (ATPISM) aim to establish a comprehensive preventive intervention strategy against idiopathic scoliosis and myopia within the HPS framework, and to assess and explore the implementation of ATPISM across five dimensions: acceptability, feasibility, adoption, usage, and maintenance. METHODS AND ANALYSIS: This is a two-phase hybrid type I effectiveness implementation trial. A 1:1 parallel-group cluster randomized controlled trial will be conducted in 30 schools (15 intervention, 15 control) across three districts in Shanghai, involving approximately 5964 students. The primary outcomes will include differences in IS and myopia screening positivity rates, body composition and behavioral indicators among children and adolescents. Secondary outcomes will assess the Reach, Effectiveness, Adoption, Implementation, and Maintenance of the ATPISM intervention using the RE-AIM framework. To account for school clustering effects, mixed-effects models will be developed to compare group differences. Subgroup analyses will be conducted to identify interaction effects (stratification factorxgroup) and examine differences in intervention effects across strata. Additionally, Difference in Differences (DID) analysis will be employed. DISCUSSION: This study is the first to apply the HPS framework for concurrent prevention of IS and myopia in China. The ATPISM strategy, centered on schools and supported by families and communities, is expected to reduce IS and myopia prevalence and improve health behaviors. Findings will provide evidence-based insights for scaling up HPS in China and offer a replicable model for global adolescent health promotion, safeguarding the physical and mental well-being of children and adolescents. TRIAL REGISTRATION: ChiCTR2600117433. Registered January 23, 2026. CI - (c) 2026. The Author(s). FAU - Zhang, Tongtong AU - Zhang T AD - Chongming Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, 202150‌, China. AD - Department of Rehabilitation, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. FAU - Li, Xin AU - Li X AD - Department of Rehabilitation, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. AD - Children's Rehabilitation Innovation and Transformation Research Center of Yuanshen Rehabilitation Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. FAU - Liang, Juping AU - Liang J AD - Department of Rehabilitation, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. FAU - Fan, Qimeng AU - Fan Q AD - Department of Rehabilitation, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. FAU - Yang, Xiaoyan AU - Yang X AD - Department of Rehabilitation, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. FAU - Lu, Huan AU - Lu H AD - Shanghai Chongming District Center for Disease Control and Prevention, Shanghai, 202162, China. FAU - Yuan, Haiyan AU - Yuan H AD - Chongming Hospital, Shanghai University of Medicine and Health Sciences, Shanghai, 202150‌, China. FAU - Wu, Fan AU - Wu F AD - Department of Rehabilitation, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. FAU - Huang, Yongfang AU - Huang Y AD - Department of Rehabilitation, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. FAU - Du, Xueli AU - Du X AD - Shanghai University of Medicine and Health Sciences, Shanghai, 201318, China. dxl0405@163.com. FAU - Du, Qing AU - Du Q AD - Department of Rehabilitation, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200092, China. duqing@xinhuamed.com.cn. AD - Children's Rehabilitation Innovation and Transformation Research Center of Yuanshen Rehabilitation Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. duqing@xinhuamed.com.cn. LA - eng GR - 202540012/Shanghai Municipal Health Commission Special Clinical Research Program in the Health Sector/ GR - ZKXM2502-03/Think Tank Research Projects of the Institute of Health Governance, Shanghai University of Medicine & Health Sciences/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20260709 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Myopia/prevention & control/epidemiology MH - Adolescent MH - China/epidemiology MH - *Scoliosis/prevention & control/epidemiology MH - Child MH - *Health Promotion/organization & administration/methods MH - Female MH - *School Health Services/organization & administration MH - Randomized Controlled Trials as Topic MH - Male MH - Program Evaluation PMC - PMC13647753 OTO - NOTNLM OT - Children and adolescents OT - Cluster randomized controlled trial OT - Health Promoting Schools OT - Idiopathic scoliosis OT - Myopia COIS- Declarations. Ethics approval and consent to participate: This study was approved by the medical ethics committee of Shanghai University of Medicine and Health Sciences, Chongming Hospital (CMEC-2025-KT-51). This study adhered to ethical standards, obtaining informed consent from both participants and their parents. All methods were carried out in accordance with relevant guidelines and regulations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/09 06:32 MHDA- 2026/10/08 05:31 PMCR- 2026/07/09 CRDT- 2026/07/09 00:18 PHST- 2026/01/25 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/10/08 05:31 [medline] PHST- 2026/07/09 06:32 [pubmed] PHST- 2026/07/09 00:18 [entrez] PHST- 2026/07/09 00:00 [pmc-release] AID - 10.1186/s12889-026-28184-5 [pii] AID - 28184 [pii] AID - 10.1186/s12889-026-28184-5 [doi] PST - epublish SO - BMC Public Health. 2026 Jul 9;26(1):2865. doi: 10.1186/s12889-026-28184-5. PMID- 42420888 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261004 IS - 1471-2334 (Electronic) IS - 1471-2334 (Linking) VI - 26 IP - 1 DP - 2026 Jul 8 TI - Diagnostic accuracy of the Fujifilm SILVAMP TB LAM II (FujiLAM II) assay for the diagnosis of childhood tuberculosis. LID - 10.1186/s12879-026-13992-2 [doi] LID - 1760 AB - BACKGROUND: Point-of-care tests (POCTs) are urgently needed to improve tuberculosis (TB) diagnosis in children. This study evaluated the diagnostic accuracy of the Fujifilm SILVAMP TB LAM II (FujiLAM II) assay for childhood TB diagnosis. METHODS: Spot urine samples were collected from children with TB (either bacteriologically confirmed or clinically diagnosed) and from healthy controls, then tested using FujiLAM II. Sensitivity was assessed against microbiological and clinical reference standards, while specificity was determined against healthy controls. RESULTS: Of 137 participants, 87 had TB and 50 were controls. FujiLAM II showed overall sensitivity of 17.2%, higher in bacteriologically confirmed cases (36.8%) than in clinically diagnosed cases (11.8%). Sensitivity was better in children under five (27.9%), HIV-positive children (25.0%), and underweight or stunted children (24.0%). Specificity was 100%. In the subgroup of 66 children tested with both assays, detection rates did not differ significantly (28.8% vs. 22.7%). When results from either test were considered positive, the detection rate increased to 40.9%, representing a 12.1% improvement over Xpert Ultra alone. CONCLUSION: FujiLAM II shows suboptimal sensitivity for childhood TB diagnosis, with better sensitivity in children under five years, HIV-positive, or malnourished, and may add value to current diagnostic algorithms. CI - (c) 2026. The Author(s). FAU - Ayalew, Sosina AU - Ayalew S AD - Armauer Hansen Research Institute, Addis Ababa, Ethiopia. absosina2011@gmail.com. AD - Department of Biology, College of Natural and Computational Sciences, Arba Minch University, Arba Minch, Ethiopia. absosina2011@gmail.com. FAU - Wegayehu, Teklu AU - Wegayehu T AD - Department of Biology, College of Natural and Computational Sciences, Arba Minch University, Arba Minch, Ethiopia. FAU - Neway, Sebsib AU - Neway S AD - Armauer Hansen Research Institute, Addis Ababa, Ethiopia. FAU - Adere, Tsion Seifu AU - Adere TS AD - Zewditu Memorial Hospital, Addis Ababa, Ethiopia. FAU - Tesfaye, Woinishet AU - Tesfaye W AD - Kidus Petros Hospital, Addis Ababa, Ethiopia. FAU - Berihun, Awokech AU - Berihun A AD - St. Paul's Hospital Millennium Medical College, Addis Ababa, Ethiopia. FAU - Wondale, Biniam AU - Wondale B AD - Department of Biology, College of Natural and Computational Sciences, Arba Minch University, Arba Minch, Ethiopia. FAU - Piantadosi, Anne AU - Piantadosi A AD - Division of Infectious Diseases, Department of Pathology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. FAU - Tessema, Bamlak AU - Tessema B AD - Armauer Hansen Research Institute, Addis Ababa, Ethiopia. FAU - Mihret, Adane AU - Mihret A AD - Armauer Hansen Research Institute, Addis Ababa, Ethiopia. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20260708 PL - England TA - BMC Infect Dis JT - BMC infectious diseases JID - 100968551 SB - IM MH - Humans MH - Sensitivity and Specificity MH - Child, Preschool MH - Female MH - Male MH - *Tuberculosis/diagnosis/urine/microbiology MH - Child MH - Infant MH - *Mycobacterium tuberculosis/isolation & purification/genetics MH - Rapid Diagnostic Tests MH - Adolescent PMC - PMC13632158 OTO - NOTNLM OT - Childhood TB OT - FujiLAM II OT - Point-of-care tests COIS- Declarations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/09 06:32 MHDA- 2026/10/03 08:38 PMCR- 2026/07/08 CRDT- 2026/07/09 00:16 PHST- 2026/01/27 00:00 [received] PHST- 2026/07/06 00:00 [accepted] PHST- 2026/10/03 08:38 [medline] PHST- 2026/07/09 06:32 [pubmed] PHST- 2026/07/09 00:16 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - 10.1186/s12879-026-13992-2 [pii] AID - 13992 [pii] AID - 10.1186/s12879-026-13992-2 [doi] PST - epublish SO - BMC Infect Dis. 2026 Jul 8;26(1):1760. doi: 10.1186/s12879-026-13992-2. PMID- 42419862 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 2632-1009 (Electronic) IS - 2632-1009 (Linking) VI - 33 IP - 1 DP - 2026 Jul 8 TI - Explainable machine learning revealing the impact of mental and physical health on arthritis. LID - 10.1136/bmjhci-2025-101955 [doi] LID - e101955 AB - OBJECTIVES: To develop a robust and interpretable machine learning framework for arthritis risk prediction and to identify important risk factors associated with the disease. METHODS: This study used four datasets, which are Behavioral Risk Factor Surveillance System (BRFSS) 2019, BRFSS 2021, National Health Interview Survey (NHIS) 2020 and NHIS 2022. We evaluated 11 machine learning and deep learning architectures including a custom stacked ensemble combined with five resampling techniques to address class imbalance and 9 imputation methods to handle missing data. Area under the receiver operating characteristic curve (AUROC), sensitivity, specificity and balanced accuracy are used to evaluate model performance, with fivefold cross-validation to ensure robustness. SHapley Additive exPlanations (SHAP) provided feature interpretability in prediction. RESULTS: The combination of the stacked ensemble, Generative Adversarial Network (GAN) imputation and random undersampling (RUS) achieved the best performance with an AUROC of 0.8007 and sensitivity of 0.8060 in the test set of BRFSS 2019. This combination also showed a balanced performance across both subgroups of male and female by maintaining high performance with AUROC of 0.808 and 0.800, respectively, in the test set of BRFSS 2021. The stacked ensemble model with GAN imputation and either Random Undersampling (RUS) or Random Oversampling (ROS) achieved the best performance across all four datasets. SHAP analysis identified higher age, walking difficulty and high body mass index (BMI) as the top physical factors. Among the psychosocial factors, parental separation showed a high impact on predicting arthritis. DISCUSSION: The risk of arthritis is influenced by health, lifestyle and childhood experiences. SHAP shows that difficulty walking, age, BMI and childhood stress play important roles in predicting arthritis risk. CONCLUSION: These results confirm important predictors of arthritis risk and provide a clear, interpretable framework. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Shams, Md Atik AU - Shams MA AUID- ORCID: 0009-0009-9984-058X AD - Department of Computer Science and Engineering, Notre Dame University Bangladesh, Dhaka, Bangladesh. AD - Department of Computer Science and Engineering, University of Asia Pacific, Dhaka, Bangladesh. FAU - Fatema, Sumaiya AU - Fatema S AUID- ORCID: 0009-0008-5662-314X AD - Department of Computer Science and Engineering, University of Asia Pacific, Dhaka, Bangladesh. FAU - Hasibul Islam, D M AU - Hasibul Islam DM AUID- ORCID: 0009-0002-0135-3169 AD - Department of Computer Science and Engineering, University of Asia Pacific, Dhaka, Bangladesh. FAU - Datta, Anindita AU - Datta A AD - Department of Fish and Wildlife Conservation, Virginia Tech, Blacksburg, Virginia, USA. FAU - Eisenberg, David AU - Eisenberg D AD - Department of Information Management and Business Analytics, Montclair State University, Montclair, New Jersey, USA. FAU - Tasaouf Mridula, Danastan AU - Tasaouf Mridula D AD - Department of Computer Science and Engineering, Northern University Bangladesh, Dhaka, Bangladesh. FAU - Mawa, Junnatul AU - Mawa J AD - Department of Computer Science and Engineering, University of Asia Pacific, Dhaka, Bangladesh. FAU - Sultana, Asma AU - Sultana A AUID- ORCID: 0009-0002-5306-5505 AD - Department of Computer Science and Engineering, University of Asia Pacific, Dhaka, Bangladesh. FAU - Ahmed, Nafiya AU - Ahmed N AD - Department of Computer Science, BRAC University, Dhaka, Bangladesh. FAU - Islam, Monowarul AU - Islam M AD - Department of Electrical and Electronic Engineering, Islamic University, Kushtia District, Bangladesh. FAU - Pias, Tanmoy Sarkar AU - Pias TS AUID- ORCID: 0000-0002-7325-9844 AD - Stanford Medicine, Stanford University, Stanford, California, USA tspias@stanford.edu. AD - Department of Computer Science, Virginia Tech, Blacksburg, Virginia, USA. LA - eng PT - Journal Article DEP - 20260708 PL - England TA - BMJ Health Care Inform JT - BMJ health & care informatics JID - 101745500 SB - IM MH - Humans MH - *Arthritis/epidemiology MH - *Machine Learning MH - Female MH - Risk Factors MH - Predictive Learning Models MH - *Mental Health MH - Male MH - *Health Status MH - Generative Adversarial Networks MH - Prediction Algorithms PMC - PMC13347896 OTO - NOTNLM OT - Artificial intelligence OT - BMJ Health Informatics OT - Public health informatics COIS- Competing interests: None declared. EDAT- 2026/07/09 04:10 MHDA- 2026/07/09 04:11 PMCR- 2026/07/08 CRDT- 2026/07/08 21:02 PHST- 2025/12/11 00:00 [received] PHST- 2026/06/21 00:00 [accepted] PHST- 2026/07/09 04:11 [medline] PHST- 2026/07/09 04:10 [pubmed] PHST- 2026/07/08 21:02 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - bmjhci-2025-101955 [pii] AID - 10.1136/bmjhci-2025-101955 [doi] PST - epublish SO - BMJ Health Care Inform. 2026 Jul 8;33(1):e101955. doi: 10.1136/bmjhci-2025-101955. PMID- 42419449 OWN - NLM STAT- Publisher LR - 20260716 IS - 1531-5037 (Electronic) IS - 0022-3468 (Linking) DP - 2026 Jul 8 TI - Assessing pediatric frailty: Use of the surgical complication index for pediatric patients (SCIPP) score to predict adverse outcomes following thoracic surgery. PG - 163288 LID - S0022-3468(26)00370-2 [pii] LID - 10.1016/j.jpedsurg.2026.163288 [doi] AB - INTRODUCTION: The Surgical Complication Index for Pediatric Patients (SCIPP) score, validated for use in pediatric neurosurgery, assesses seven components of frailty for a composite score: independence in performing activities of daily living (ADLs), autonomic function, body mass index (BMI), continence, previous admissions, mobility, and polypharmacy, while a reduced SCIPP score utilizes ADLs, autonomic function, and polypharmacy components. This study aimed to understand the predictive performance of full and reduced SCIPP score in children undergoing thoracic operations. METHODS: A single-center retrospective review of patients age 2-18 years undergoing thoracic surgery from 2020 to 2025 was conducted, excluding patients with missing components of SCIPP score. Full and reduced SCIPP scores were calculated. Operative details and postoperative outcomes with 1-month follow-up were collected. Multiple logistic regression assessed the association between SCIPP scores, complications, and length of stay (LOS). RESULTS: We included 317 patients. SCIPP scores were 0-1 in 70.7%, 2-3 in 18.0%, and 4+ in 11.4%. Logistic regression found that for every 1-point increase in full and reduced SCIPP scores, patients were 2.19 and 3.24 times more likely to have any complication, respectively (p < 0.001). LOS increased by 26% for each point greater in full SCIPP score and 44% for reduced SCIPP score (p < 0.001). CONCLUSION: The SCIPP score, a composite pediatric frailty index, can predict a patient's risk of complications and likelihood of increased LOS following thoracic surgery. There is a role for SCIPP score utilization, particularly the reduced score, in the preoperative setting to optimize parental counseling, risk assessment, and determination of prehabilitation needs. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Vincent, Sage A AU - Vincent SA AD - Division of Pediatric Surgery, Children's Hospital Colorado, 13123 E 16th Ave B323, Aurora CO, 80045, USA. Electronic address: Sage.Vincent@cuanschutz.edu. FAU - Easwaran, Lavanya AU - Easwaran L AD - Division of Pediatric Surgery, Children's Hospital Colorado, 13123 E 16th Ave B323, Aurora CO, 80045, USA; Department of Pediatrics, University of Colorado School of Medicine, Anschutz Medical Campus, 13123 E 16th Avenue, Aurora CO 80045, USA. FAU - Tong, Suhong AU - Tong S AD - Research Outcomes in Children's Surgery, Center for Children's Surgery, Children's Hospital Colorado, 13123 E 16th Ave, Aurora CO 80045, USA. FAU - Diaz-Miron, Jose AU - Diaz-Miron J AD - Division of Pediatric Surgery, Children's Hospital Colorado, 13123 E 16th Ave B323, Aurora CO, 80045, USA. FAU - Khurana, Eeshan AU - Khurana E AD - Sidney Kimmel Medical College, Thomas Jefferson University, 1025 Walnut St, Suite 100, Philadelphia PA 19107, USA. FAU - Mazzola, Catherine A AU - Mazzola CA AD - New Jersey Pediatric Neuroscience Institute, 131 Madison Ave, Morristown NJ 07960, USA. FAU - Acker, Shannon N AU - Acker SN AD - Division of Pediatric Surgery, Children's Hospital Colorado, 13123 E 16th Ave B323, Aurora CO, 80045, USA. LA - eng PT - Journal Article DEP - 20260708 PL - United States TA - J Pediatr Surg JT - Journal of pediatric surgery JID - 0052631 SB - IM OTO - NOTNLM OT - Complications OT - Frailty OT - Frailty score OT - Length of stay OT - Thoracic surgery COIS- Conflicts of interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Jose Diaz-Miron reports a relationship with MedCore Technologies Corporation that includes: consulting or advisory. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/09 04:10 MHDA- 2026/07/09 04:10 CRDT- 2026/07/08 19:11 PHST- 2026/03/16 00:00 [received] PHST- 2026/06/16 00:00 [revised] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/07/09 04:10 [pubmed] PHST- 2026/07/09 04:10 [medline] PHST- 2026/07/08 19:11 [entrez] AID - S0022-3468(26)00370-2 [pii] AID - 10.1016/j.jpedsurg.2026.163288 [doi] PST - aheadofprint SO - J Pediatr Surg. 2026 Jul 8:163288. doi: 10.1016/j.jpedsurg.2026.163288. PMID- 42419373 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260821 IS - 1439-1899 (Electronic) IS - 0174-304X (Linking) VI - 57 IP - 4 DP - 2026 Aug TI - Primary Headache in Children: Clinical Characteristics and Impact on School Functioning in a Low-Resource Country. PG - 280-285 LID - 10.1055/a-2886-4833 [doi] AB - BACKGROUND: Primary headaches in children impair daily functioning, yet data from Jordan, particularly regarding their effect on school functioning, have not been systematically evaluated. OBJECTIVE: The objective of this study is to assess the clinical characteristics of pediatric primary headaches in central Jordan and their association with school functioning. METHODS: A cross-sectional study included children aged 5 to 18 years diagnosed with primary headaches at three public hospitals. Data were collected using a structured, culturally adapted questionnaire incorporating items from the validated Arabic PedsQL 4.0 school-functioning scale. Descriptive, univariable, and multivariable analyses were performed to identify factors associated with impaired school functioning. RESULTS: A total of 147 children were included (51% male; 61.2% aged 10-14 years). Migraine was most common (60.5%), followed by tension-type headache (23.8%). Common triggers included stress, noise, and sleep disturbance. Unfavorable lifestyle factors-increased screen time, skipped meals, low hydration, and limited physical activity-were prevalent. More than 92% of participants had impairment in at least one school-functioning domain. Poor academic performance and lower parental education were significantly associated with lower scores. In multivariable analysis, poorer academic performance and lower paternal education remained independently associated with worse school-functioning scores, whereas headache type and frequency were not significant predictors. Most patients used simple analgesics (paracetamol in 93%), whereas migraine-specific rescue medications and preventive therapies were rarely used. CONCLUSION: Primary headaches in children are associated with substantial impairment in school functioning. Educational and family-related factors appear more influential than headache-specific variables. Addressing modifiable lifestyle and contextual factors may improve outcomes. CI - Thieme. All rights reserved. FAU - Abu Libdeh, Amal AU - Abu Libdeh A AUID- ORCID: 0000-0001-5409-0230 AD - The University of Jordan, School of Medicine, Department of Pediatrics, Jordan, Amman. FAU - Alsubehat, Lara AU - Alsubehat L AUID- ORCID: 0009-0007-3621-3971 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Tabbalat, Nada AU - Tabbalat N AUID- ORCID: 0009-0006-6376-8131 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Mraish, Shahed AU - Mraish S AUID- ORCID: 0009-0004-9804-9845 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Al-Nawaiseh, Noura AU - Al-Nawaiseh N AUID- ORCID: 0009-0006-7756-2548 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Arabiyat, Nadine AU - Arabiyat N AUID- ORCID: 0009-0008-2397-3178 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Elayyan, Mustafa AU - Elayyan M AUID- ORCID: 0009-0004-2465-4436 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Al-Daraghmeh, Mohammad AU - Al-Daraghmeh M AUID- ORCID: 0009-0002-0316-0192 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Hussein, Hani AU - Hussein H AUID- ORCID: 0009-0006-8108-8025 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Deameh, Mohammad AU - Deameh M AUID- ORCID: 0009-0005-6197-3273 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Alshadfan, Lina AU - Alshadfan L AUID- ORCID: 0000-0003-4832-5149 AD - Al-Balqa Applied University, Faculty of Medicine, Department of Pediatrics, Jordan, As-Salt. FAU - Masri, Amira AU - Masri A AUID- ORCID: 0000-0001-6103-8713 AD - The University of Jordan, School of Medicine, Department of Pediatrics, Jordan, Amman. LA - eng PT - Journal Article DEP - 20260708 PL - Germany TA - Neuropediatrics JT - Neuropediatrics JID - 8101187 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Cross-Sectional Studies MH - Jordan/epidemiology MH - Adolescent MH - Child, Preschool MH - *Migraine Disorders/epidemiology MH - *Tension-Type Headache/epidemiology MH - *Academic Performance MH - Developing Countries COIS- The authors declare that they have no conflict of interest. EDAT- 2026/07/09 00:40 MHDA- 2026/08/21 23:37 CRDT- 2026/07/08 19:03 PHST- 2026/08/21 23:37 [medline] PHST- 2026/07/09 00:40 [pubmed] PHST- 2026/07/08 19:03 [entrez] AID - 10.1055/a-2886-4833 [doi] PST - ppublish SO - Neuropediatrics. 2026 Aug;57(4):280-285. doi: 10.1055/a-2886-4833. Epub 2026 Jul 8. PMID- 42419163 OWN - NLM STAT- MEDLINE DCOM- 20260812 LR - 20260812 IS - 1873-3360 (Electronic) IS - 0306-4530 (Linking) VI - 192 DP - 2026 Oct TI - Beyond a simple marker of stress: A multiverse analysis of biopsychosocial associations with hair cortisol and cortisone. PG - 107953 LID - S0306-4530(26)00213-1 [pii] LID - 10.1016/j.psyneuen.2026.107953 [doi] AB - BACKGROUND: Hair concentrations of cortisol and cortisone are increasingly used as potential biomarkers of chronic stress. However, their validity as indicators of psychosocial stress remains debated, as prior research shows variable associations with stress-related psychological and behavioral factors. This study systematically investigates a broad set of biopsychosocial correlates of hair glucocorticoids in young adults, leveraging a multiverse framework to evaluate the robustness of associations often reported as variable in prior work. METHODS: Using data from the Zurich Project on the Social Development from Childhood to Adulthood, a large community-based age cohort, we employed a multiverse analysis to explore relationships between more than 60 biological, psychological, and contextual variables and three hair-based outcomes (cortisol, cortisone, and a combined score of both) at ages 20 (n = 1,002) and 24 (n = 887). Specification curve analyses were performed on the full sample and separately by sex, systematically varying model choices (i.e., inclusion/exclusion of covariates). RESULTS: Hair characteristics (i.e., color, washing intensity, chemical treatment), sampling season, body mass index, and, among women, hormonal contraception, showed strong associations with glucocorticoids and were included as covariates. Sweating intensity was associated with glucocorticoids primarily in females, but not in males. Hair concentrations of drugs (i.e., Delta9-tetrahydrocannabinol, cocaine, 3,4-methylenedioxymethamphetamine [MDMA, "Ecstasy"], paracetamol) and the hormone testosterone were consistently linked to steroid outcomes. Several psychosocial factors were associated with hair glucocorticoids: migration background, perceived stress, symptoms of anxiety/depression, sports activity, and social exclusion. These factors exhibited stronger correlations with cortisol, while media use, aggression, and effective coping were more closely associated with cortisone. The combined steroid score mainly reflected associations detected for cortisol, but with weaker effect sizes. Associations varied descriptively by age and sex, with more associations detected in males at age 20 and in females at age 24. CONCLUSION: In cohort studies, corticosteroids in hair can reflect specific facets of psychosocial stress when critical confounders and sex are considered. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Janousch, Clarissa AU - Janousch C AD - Experimental Pharmacopsychology and Psychological Addiction Research, Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland; Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland; Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. Electronic address: clarissa.janousch@ki.se. FAU - Eggenberger, Lukas AU - Eggenberger L AD - Experimental Pharmacopsychology and Psychological Addiction Research, Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland; Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland. FAU - Johnson-Ferguson, Lydia AU - Johnson-Ferguson L AD - Experimental Pharmacopsychology and Psychological Addiction Research, Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland; Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland; Suchtfachstelle Zurich, Zurich, Switzerland. FAU - Voegel, Clarissa D AU - Voegel CD AD - Center for Forensic Hair Analytics, Zurich Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland. FAU - Baumgartner, Markus R AU - Baumgartner MR AD - Center for Forensic Hair Analytics, Zurich Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland. FAU - Ribeaud, Denis AU - Ribeaud D AD - Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland. FAU - Eisner, Manuel AU - Eisner M AD - Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland; Institute of Criminology, University of Cambridge, Cambridge, United Kingdom. FAU - Binz, Tina M AU - Binz TM AD - Center for Forensic Hair Analytics, Zurich Institute of Forensic Medicine, University of Zurich, Zurich, Switzerland. FAU - Shanahan, Lilly AU - Shanahan L AD - Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland; Institute of Psychology, University of Zurich, Zurich, Switzerland. FAU - Quednow, Boris B AU - Quednow BB AD - Experimental Pharmacopsychology and Psychological Addiction Research, Department of Adult Psychiatry and Psychotherapy, University Hospital of Psychiatry Zurich, University of Zurich, Zurich, Switzerland; Jacobs Center for Productive Youth Development, University of Zurich, Zurich, Switzerland. LA - eng PT - Journal Article DEP - 20260703 PL - England TA - Psychoneuroendocrinology JT - Psychoneuroendocrinology JID - 7612148 RN - V27W9254FZ (Cortisone) RN - WI4X0X7BPJ (Hydrocortisone) RN - 0 (Biomarkers) RN - 0 (Glucocorticoids) SB - IM MH - Humans MH - *Cortisone/analysis/metabolism MH - Female MH - *Hair/chemistry MH - *Hydrocortisone/analysis/metabolism MH - Male MH - *Stress, Psychological/metabolism MH - Biomarkers/analysis MH - Young Adult MH - Cohort Studies MH - Glucocorticoids/analysis MH - Adult OTO - NOTNLM OT - Allostatic load OT - Deep phenotyping OT - Glucocorticoids OT - Hair cortisol OT - Inflammation OT - Specification curve analysis COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/09 04:10 MHDA- 2026/08/12 23:34 CRDT- 2026/07/08 18:09 PHST- 2026/01/20 00:00 [received] PHST- 2026/06/30 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/08/12 23:34 [medline] PHST- 2026/07/09 04:10 [pubmed] PHST- 2026/07/08 18:09 [entrez] AID - S0306-4530(26)00213-1 [pii] AID - 10.1016/j.psyneuen.2026.107953 [doi] PST - ppublish SO - Psychoneuroendocrinology. 2026 Oct;192:107953. doi: 10.1016/j.psyneuen.2026.107953. Epub 2026 Jul 3. PMID- 42418514 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260903 IS - 1536-4844 (Electronic) IS - 1078-0998 (Print) IS - 1078-0998 (Linking) VI - 32 IP - 9 DP - 2026 Sep 1 TI - Metabolome remodeling with reverse-engineered exclusive enteral nutrition in children with active Crohn's disease. PG - 1683-1694 LID - 10.1093/ibd/izag095 [doi] AB - BACKGROUND: For children with Crohn's disease (CD), dietary therapy with exclusive enteral nutrition (EEN) is effective in achieving clinical and biochemical remission. We investigated changes in metabolites in multiple clinical sample types from children with CD following a whole foods-blended ("reverse-engineered") EEN formula and defined associations between these changes and remission. METHODS: Stool, urine, serum, and plasma from a prospective study of newly diagnosed pediatric patients with CD enrolled in a 4-week trial of reverse-engineered exclusive enteral nutrition (RE-EEN) were analyzed using mass spectrometry targeting aqueous metabolites, bile acids, and short-chain fatty acids. Principal component analysis, mixed-effects models, and exploratory multivariate approaches including random forest and partial least-squares discriminant analysis were used to identify patterns associated with diet and metabolite abundances. RESULTS: Fecal, urine, serum, and plasma metabolomes changed significantly during RE-EEN treatment from baseline. These global changes were largely driven by increases in amino acids and related metabolites and decreases in different amino acids and metabolites reflecting carbohydrate and purine metabolism, in all sample types. While global bile acid profiles changed with the RE-EEN diet, no changes in specific bile acid levels reached significance, and no changes were found in short-chain fatty acid concentrations. CONCLUSION: Metabolomic profiles for pediatric patients with CD changed broadly during RE-EEN, indicating that this therapy may modulate key systemic and gut-associated metabolic processes. The findings further suggest that the gut metabolic processes influenced by RE-EEN, and that contribute to clinical improvement, may differ from those impacted by commercial EEN diets. Further research is crucial to validate these findings, uncover causal relationships, and optimize dietary protocols to enhance therapeutic outcomes in CD. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Suskind, David L AU - Suskind DL AUID- ORCID: 0000-0002-3524-5150 AD - Inflammatory Bowel Disease Center, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Seattle Children's Hospital, Seattle, WA 98105, United States. FAU - Hoffman, Lucas R AU - Hoffman LR AUID- ORCID: 0000-0001-8864-6751 AD - Department of Microbiology, University of Washington, Seattle, WA 98195, United States. FAU - Lee, Dale AU - Lee D AD - Inflammatory Bowel Disease Center, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Seattle Children's Hospital, Seattle, WA 98105, United States. FAU - Verster, Adrian J AU - Verster AJ AD - Pythia Informatics, Ottawa, ON K1S 0S7, Canada. FAU - Zheng, Hengqi Betty AU - Zheng HB AD - Inflammatory Bowel Disease Center, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Seattle Children's Hospital, Seattle, WA 98105, United States. FAU - Francis, Kendra AU - Francis K AD - Inflammatory Bowel Disease Center, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Seattle Children's Hospital, Seattle, WA 98105, United States. FAU - Nuding, Mason AU - Nuding M AD - Inflammatory Bowel Disease Center, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Seattle Children's Hospital, Seattle, WA 98105, United States. FAU - Vanamala, Jairam AU - Vanamala J AD - Inflammatory Bowel Disease Center, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Seattle Children's Hospital, Seattle, WA 98105, United States. FAU - Wahbeh, Ghassan AU - Wahbeh G AD - Inflammatory Bowel Disease Center, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Seattle Children's Hospital, Seattle, WA 98105, United States. FAU - Purcell, Hayley AU - Purcell H AD - Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98109, United States. FAU - Djukovic, Danijel AU - Djukovic D AUID- ORCID: 0000-0001-5954-8810 AD - Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98109, United States. FAU - Raftery, Daniel AU - Raftery D AUID- ORCID: 0000-0003-2467-8118 AD - Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98109, United States. FAU - Hayden, Hillary S AU - Hayden HS AUID- ORCID: 0000-0001-7372-9853 AD - Department of Microbiology, University of Washington, Seattle, WA 98195, United States. LA - eng GR - Richards Family Foundation/ GR - K24HL141669/NH/NIH HHS/United States GR - P30 DK035816/DK/NIDDK NIH HHS/United States GR - K24HL141669/NH/NIH HHS/United States GR - P30 DK035816/NH/NIH HHS/United States PT - Journal Article PL - England TA - Inflamm Bowel Dis JT - Inflammatory bowel diseases JID - 9508162 RN - 0 (Bile Acids and Salts) RN - Pediatric Crohn's disease SB - IM MH - Humans MH - *Crohn Disease/therapy/metabolism MH - *Enteral Nutrition/methods MH - Female MH - Male MH - *Metabolome MH - Child MH - Prospective Studies MH - Adolescent MH - Bile Acids and Salts/metabolism MH - Food, Formulated MH - Feces/chemistry MH - Prognosis MH - Follow-Up Studies MH - Metabolomics PMC - PMC13533203 OAB - In children with active Crohn's disease, a whole-foods-based enteral diet (reverse-engineered exclusive enteral nutrition) induced remission and broadly altered metabolites in stool, urine, and blood. These findings suggest that reverse-engineered exclusive enteral nutrition influences distinct metabolic pathways compared with commercial formulas, highlighting potential for tailored nutrition. OABL- eng OTO - NOTNLM OT - Crohn's disease OT - exclusive enteral nutrition OT - metabolomics OT - nutrition COIS- D.L.S. has written Nutrition in Immune Balance (NIMBAL) Therapy: Using Diet to Treat Inflammatory Bowel Disease, a lay book on diet in inflammatory bowel disease; and served as a consultant for Abbott Nutrition and Nestle Health Sciences. All other authors disclose no conflicts. EDAT- 2026/07/08 22:41 MHDA- 2026/09/01 17:39 PMCR- 2027/07/08 CRDT- 2026/07/08 13:44 PHST- 2025/09/02 00:00 [received] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/09/01 17:39 [medline] PHST- 2026/07/08 22:41 [pubmed] PHST- 2026/07/08 13:44 [entrez] PHST- 2027/07/08 00:00 [pmc-release] AID - 8728491 [pii] AID - izag095 [pii] AID - 10.1093/ibd/izag095 [doi] PST - ppublish SO - Inflamm Bowel Dis. 2026 Sep 1;32(9):1683-1694. doi: 10.1093/ibd/izag095. PMID- 42418464 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Development and psychometric evaluation of the Spanish Cooking Self-Efficacy Questionnaire (SCSEQ) for Spanish University Students. PG - e0352758 LID - 10.1371/journal.pone.0352758 [doi] LID - e0352758 AB - The transition to university is a critical life stage characterized by increased autonomy, identity exploration, and new social and environmental influences. During this period, university students often exhibit low adherence to dietary guidelines. Among the determinants influencing healthy eating, cooking self-efficacy, the central construct of Social Cognitive Theory (SCT), is consistently associated with improved diet quality and is a frequent target of health interventions. However, no validated instrument exists to assess this construct among university students in Spain. Therefore, the goal was to develop and provide preliminary evidence of the Spanish Cooking Self-Efficacy Questionnaire (SCSEQ), a concise SCT-based instrument tailored to Mediterranean university settings. A 32-item questionnaire was developed through a review of existing instruments assessing cooking self-efficacy. Face validity was evaluated with Spanish food and nutrition experts (n = 12) to assess the clarity and pertinence of the initial items. The revised Spanish Cooking Self-Efficacy Questionnaire (SCSEQ) was then pilot-tested with Spanish university students (n = 73) from four Catalan universities. Exploratory factor analysis (EFA) was conducted to identify the underlying factor structure and detect problematic items. Internal consistency reliability was assessed using McDonald's omega, and test-retest reliability over a two-week interval was evaluated using Pearson correlations. Face validity indicated overall clarity and adequacy. Four items were excluded and recombined, two items were added, and nine items were rewritten based on experts' feedback. After pilot testing, the questionnaire overall demonstrated high internal consistency (omega = 0.9). Items were reviewed based on factor loadings, item redundancy, theoretical relevance, and their contribution to scale-level internal consistency. EFA suggested a two-factor structure with good internal consistency (omega = 0.88 and omega = 0.82) and test-retest reliability (ICC = 0.91, 95% CI [0.80, 0.96]). Three items with weak loadings were excluded. The final version consisted of 25 items and 2 subscales. The SCSEQ showed favorable preliminary psychometric properties. CI - Copyright: (c) 2026 Jurado-Gonzalez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Jurado-Gonzalez, Patricia AU - Jurado-Gonzalez P AUID- ORCID: 0000-0003-0632-0390 AD - NUTRALiSS, Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. FAU - Medina, F Xavier AU - Medina FX AUID- ORCID: 0000-0002-8067-355X AD - Epi4Health Research Group, Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. AD - UNESCO Chair on Food, Culture and Development, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. FAU - Martinez-Garcia, Alba AU - Martinez-Garcia A AD - Department of Community Nursing, Preventive Medicine, Public Health and History of Science, University of Alicante, Alicante, Spain. FAU - Lopez-Cediel Verdu, Almudena AU - Lopez-Cediel Verdu A AD - Talent Data Scientist, Data Scientist and Psychometric Specialist, Madrid, Spain. FAU - Fabregues, Sergi AU - Fabregues S AUID- ORCID: 0000-0003-1141-7613 AD - NUTRALiSS, Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. AD - Department of Psychology and Education, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. FAU - Bach-Faig, Anna AU - Bach-Faig A AD - NUTRALiSS, Faculty of Health Sciences, Universitat Oberta de Catalunya (Open University of Catalonia, UOC), Barcelona, Spain. LA - eng PT - Journal Article DEP - 20260708 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Students/psychology MH - *Self Efficacy MH - *Psychometrics/methods MH - Female MH - Spain MH - *Cooking MH - Male MH - Universities MH - Surveys and Questionnaires MH - Young Adult MH - Adult MH - Reproducibility of Results MH - Adolescent PMC - PMC13345255 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/08 18:52 MHDA- 2026/07/08 18:53 PMCR- 2026/07/08 CRDT- 2026/07/08 13:43 PHST- 2026/04/25 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/07/08 18:53 [medline] PHST- 2026/07/08 18:52 [pubmed] PHST- 2026/07/08 13:43 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - PONE-D-26-19104 [pii] AID - 10.1371/journal.pone.0352758 [doi] PST - epublish SO - PLoS One. 2026 Jul 8;21(7):e0352758. doi: 10.1371/journal.pone.0352758. eCollection 2026. PMID- 42418453 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Knowledge, attitudes, and practices regarding type 2 diabetes and associated factors among rural adolescents in Indonesia: A cross-sectional study. PG - e0352982 LID - 10.1371/journal.pone.0352982 [doi] LID - e0352982 AB - INTRODUCTION: Type 2 diabetes (T2D) is an increasingly important public health concern in Indonesia and is increasingly affecting adolescents at a growing rate due to lifestyle transitions and limited awareness. Evidence regarding adolescents' knowledge, attitudes, and practices (KAP) toward T2D in rural settings remains limited. This study assessed KAP levels related to T2D, identified sociodemographic factors associated with KAP outcomes, and examined interrelationships among KAP domains among rural Indonesian adolescents. METHODS: A cross-sectional study was conducted from September 2024 to February 2025 among 1,546 senior high school students in Kampar Regency, Riau Province. Participants were selected using multistage cluster sampling. Data were collected using a validated KAP questionnaire (Cronbach's alpha = 0.725). Descriptive and inferential statistics, including Mann-Whitney U tests, Kruskal-Wallis tests, Spearman's rank correlations, and multiple linear regression analyses, were used to examine KAP outcomes and associated factors. RESULTS: Participants demonstrated limited knowledge regarding T2D, particularly related to risk factors, symptoms, and complications. Although attitudes toward diabetes prevention were generally positive, preventive practices remained suboptimal, especially regarding physical activity. Female gender, peri-urban school location, higher academic rank, extracurricular participation, and prior exposure to diabetes information were associated with higher KAP scores. Knowledge was moderately associated with attitude but only weakly associated with preventive practices. CONCLUSIONS: Rural adolescents demonstrated limited diabetes-related knowledge and suboptimal preventive behaviors despite generally positive attitudes toward T2D prevention. Several sociodemographic and school-related factors were associated with KAP outcomes. However, the weak relationship between knowledge and practice highlights a persistent gap between awareness and preventive behavior. School-based, peer-led, and after-school interventions that integrate education with behavioral reinforcement may strengthen diabetes prevention efforts among rural adolescents. CI - Copyright: (c) 2026 Kusumawati et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Kusumawati, Nila AU - Kusumawati N AUID- ORCID: 0000-0002-0967-228X AD - Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, United States of America. AD - Indonesian Diabetes Center, Universitas Pahlawan Tuanku Tambusai, Kampar, Riau Province, Indonesia. FAU - Pijl, Hanno AU - Pijl H AD - Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands. FAU - Alaofe, Halimatou AU - Alaofe H AUID- ORCID: 0000-0002-3011-9673 AD - Department of Health Promotion Sciences, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, Arizona, United States of America. FAU - Yani, Emul AU - Yani E AD - Faculty of Nursing, Institut Kesehatan Payung Negeri Pekanbaru, Pekanbaru, Riau Province, Indonesia. FAU - Puswati, Desti AU - Puswati D AD - Faculty of Nursing, Institut Kesehatan Payung Negeri Pekanbaru, Pekanbaru, Riau Province, Indonesia. FAU - Hamid, Abdul AU - Hamid A AD - Indonesian Diabetes Center, Universitas Pahlawan Tuanku Tambusai, Kampar, Riau Province, Indonesia. LA - eng PT - Journal Article DEP - 20260708 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - Adolescent MH - Male MH - *Health Knowledge, Attitudes, Practice MH - *Diabetes Mellitus, Type 2/epidemiology/prevention & control/psychology MH - Cross-Sectional Studies MH - Indonesia/epidemiology MH - Rural Population MH - Surveys and Questionnaires MH - Risk Factors PMC - PMC13345253 COIS- The authors have declared that no competing interests exist. EDAT- 2026/07/08 18:52 MHDA- 2026/07/08 18:53 PMCR- 2026/07/08 CRDT- 2026/07/08 13:43 PHST- 2025/11/27 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/07/08 18:53 [medline] PHST- 2026/07/08 18:52 [pubmed] PHST- 2026/07/08 13:43 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - PONE-D-25-61411 [pii] AID - 10.1371/journal.pone.0352982 [doi] PST - epublish SO - PLoS One. 2026 Jul 8;21(7):e0352982. doi: 10.1371/journal.pone.0352982. eCollection 2026. PMID- 42418153 OWN - NLM STAT- Publisher LR - 20260708 IS - 2042-7174 (Electronic) IS - 0961-7671 (Linking) DP - 2026 Jul 8 TI - Assessing confidence of community pharmacists in inflammatory bowel disease management: a cross-sectional study in Malta. LID - riag089 [pii] LID - 10.1093/ijpp/riag089 [doi] AB - OBJECTIVES: To evaluate community pharmacists' confidence in the management of inflammatory bowel disease (IBD) and to identify areas in which pharmacist-led patient education and counselling could be strengthened. METHODS: This cross-sectional study was conducted in three phases; questionnaire development and review by an expert panel, reliability assessment, and dissemination to 100 community pharmacies selected through stratified random sampling across Malta. Pharmacists' confidence across 29 items was assessed using mean rating scores (MRS) on a 5-point Likert scale. Non-parametric analyses examined associations between confidence, demographic variables, and perceived barriers (P < .05 statistically significant). KEY FINDINGS: Ninety-four pharmacists completed the questionnaire; female (n = 65), > 5 years of community pharmacy experience (n = 56), worked 31-40 hours weekly (n = 39), Master of Pharmacy degree (n = 47). 'High' confidence (MRS >/=4/5) was reported for advice on diet and lifestyle, non-prescription medicines for symptom management, medicine storage/stability, and recognizing when referral was required. 'Moderate' confidence (MRS 3 to <4/5) was observed for adherence support, relapse, counselling on extraintestinal complications, dosage form administration, corticosteroids, methotrexate, aminosalicylates, and biologics. 'Low' confidence (MRS <3/5) was identified for counselling on thiopurines, non-prescription medicines associated with toxic megacolon, vaccines, and pregnancy and women of child-bearing age. The main reported barriers to providing advice were time constraints (n = 70) and patient-related communication challenges (n = 63). Years of experience, hours of practice, and inadequate private consultation space were not significantly associated with pharmacist confidence (P > .05). CONCLUSIONS: Community pharmacists were more confident in general counselling and referral-related support than in medication-specific counselling and more complex aspects of IBD care. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Royal College of Pharmacy. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Diyab, Aisha AU - Diyab A AD - Department of Pharmacy, Faculty of Medicine and Surgery, University of Malta, Msida, MSD 2080, Malta. FAU - Wirth, Francesca AU - Wirth F AUID- ORCID: 0000-0002-3225-2363 AD - Department of Pharmacy, Faculty of Medicine and Surgery, University of Malta, Msida, MSD 2080, Malta. LA - eng PT - Journal Article DEP - 20260708 PL - England TA - Int J Pharm Pract JT - The International journal of pharmacy practice JID - 9204243 SB - IM OTO - NOTNLM OT - community pharmacy services OT - counselling OT - inflammatory bowel disease OT - patient education OT - pharmacists EDAT- 2026/07/08 12:57 MHDA- 2026/07/08 12:57 CRDT- 2026/07/08 11:23 PHST- 2025/09/24 00:00 [received] PHST- 2026/05/25 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/07/08 12:57 [medline] PHST- 2026/07/08 12:57 [pubmed] PHST- 2026/07/08 11:23 [entrez] AID - 8728405 [pii] AID - 10.1093/ijpp/riag089 [doi] PST - aheadofprint SO - Int J Pharm Pract. 2026 Jul 8:riag089. doi: 10.1093/ijpp/riag089. PMID- 42417925 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20261008 IS - 0973-7693 (Electronic) IS - 0019-5456 (Linking) VI - 93 IP - 9 DP - 2026 Sep TI - A Simple Clinical Prediction Model for Metabolic Dysfunction-Associated Steatotic Liver Disease in Adolescents with Obesity. PG - 933-938 LID - 10.1007/s12098-026-06301-x [doi] AB - OBJECTIVES: To develop and validate a simple, office-based screening tool for metabolic dysfunction-associated steatotic liver disease (MASLD) in adolescents with obesity using readily available clinical indicators. METHODS: This cross-sectional study utilized NHANES 2021-2023 data (derivation cohort, n = 100) and 2017-2020 data (temporal validation cohort, n = 149). MASLD was defined as controlled attenuation parameter (CAP) >/=245 dB/m. Model performance was assessed using area under the receiver operating characteristic curve (AUC). RESULTS: A simplified three-variable model incorporating alanine aminotransferase (ALT), triglycerides, and waist circumference demonstrated excellent discrimination (AUC 0.809, 95% CI: 0.721-0.897) in derivation and remained robust in validation (AUC 0.725, 95% CI: 0.636-0.814). Inclusion of homeostasis model assessment of insulin resistance (HOMA-IR) did not significantly improve performance (DeLong P >0.05). CONCLUSIONS: This validated three-parameter model requires no specialized tests or insulin measurement, providing a practical tool for frontline pediatricians to stratify MASLD risk during routine visits. CI - (c) 2026. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation. FAU - Liao, Yang AU - Liao Y AUID- ORCID: 0009-0002-9412-4487 AD - Department of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai, 201399, China. dr_liaoyang@163.com. FAU - Wang, Fei AU - Wang F AD - Department of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai, 201399, China. FAU - Tian, Ting-Ting AU - Tian TT AD - Department of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai, 201399, China. FAU - Li, Xiu-Fen AU - Li XF AD - Department of Pediatrics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, 2800 Gongwei Road, Pudong, Shanghai, 201399, China. LA - eng PT - Journal Article DEP - 20260708 PL - India TA - Indian J Pediatr JT - Indian journal of pediatrics JID - 0417442 RN - EC 2.6.1.2 (Alanine Transaminase) RN - 0 (Triglycerides) SB - IM MH - Humans MH - Cross-Sectional Studies MH - Adolescent MH - Female MH - Male MH - *Fatty Liver/diagnosis/etiology MH - Alanine Transaminase/blood MH - *Pediatric Obesity/complications MH - Triglycerides/blood MH - Insulin Resistance MH - Nutrition Surveys MH - Waist Circumference OTO - NOTNLM OT - Adolescent OT - Alanine aminotransferase OT - Metabolic dysfunction-associated steatotic liver disease OT - Pediatric obesity OT - Screening tool OT - Triglycerides OT - Waist circumference COIS- Declarations. Conflict of Interest: None. EDAT- 2026/07/08 12:56 MHDA- 2026/08/28 11:46 CRDT- 2026/07/08 11:06 PHST- 2026/02/19 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/08/28 11:46 [medline] PHST- 2026/07/08 12:56 [pubmed] PHST- 2026/07/08 11:06 [entrez] AID - 10.1007/s12098-026-06301-x [pii] AID - 10.1007/s12098-026-06301-x [doi] PST - ppublish SO - Indian J Pediatr. 2026 Sep;93(9):933-938. doi: 10.1007/s12098-026-06301-x. Epub 2026 Jul 8. PMID- 42416279 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 2235-2988 (Electronic) IS - 2235-2988 (Linking) VI - 16 DP - 2026 TI - Rapid and low-cost detection of six major pediatric enteric pathogens using a closed-tube PCR-invasive reaction assay. PG - 1841155 LID - 10.3389/fcimb.2026.1841155 [doi] LID - 1841155 AB - Diarrhea caused by bacterial and viral pathogens remains a major cause of childhood morbidity and mortality, leading to dehydration, malnutrition, and substantial healthcare burdens; rapid and accurate diagnosis is therefore essential for timely treatment. In clinical practice, detection still commonly relies on traditional methods such as stool culture and enzyme-linked immunosorbent assays. These approaches are not only time-consuming and lack sensitivity but also typically require separate, pathogen-specific tests, complicating comprehensive diagnosis. While quantitative PCR (qPCR) offers speed and sensitivity, dye-based methods lack specificity, and fluorescent probe-based assays are costly. To address these limitations, we developed an integrated assay that combines PCR with a sequence-specific invasive reaction (Invader) in a single closed tube. This method detects six major pediatric enteric pathogens: Shigella spp., Vibrio cholerae, non-typhoidal Salmonella, Campylobacter jejuni, rotavirus, and enteric adenovirus (types 40/41). The assay demonstrated high sensitivity, with detection limits as low as 2 copies per reaction for each target and exhibited no cross-reactivity. The entire process was completed within 45 minutes. By employing universal Invader probes, we reduced the cost per test to approximately 2 RMB. Validation using both simulated and clinical stool samples suggested the assay's potential reliability and consistency with standard methods. This closed-tube PCR-Invader assay provides a rapid, cost-effective, and unified platform for the parallel detection of six major diarrheal pathogens in a single test run. It shows promise as a practical alternative to current disparate and pathogen-specific testing strategies, with considerable potential for use in primary healthcare settings and large-scale screening to guide the management of childhood infectious diarrhea. CI - Copyright (c) 2026 Yang, Zhou, Zhang, Huang, Kong, Zheng, Zhang, Shen, Han, Liu and Lu. FAU - Yang, Nan AU - Yang N AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Zhou, Jin AU - Zhou J AD - Department of Clinical Laboratory, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Zhang, Han AU - Zhang H AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Huang, Yihsuan AU - Huang Y AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Kong, Guiping AU - Kong G AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Zheng, Yucan AU - Zheng Y AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Zhang, Zhuo AU - Zhang Z AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Shen, Ying AU - Shen Y AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Han, Xiu AU - Han X AD - School of Basic Medical Sciences, Faculty of Medicine, Yangzhou University, Yangzhou, China. FAU - Liu, Zhifeng AU - Liu Z AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Lu, Yan AU - Lu Y AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. LA - eng PT - Journal Article DEP - 20260623 PL - Switzerland TA - Front Cell Infect Microbiol JT - Frontiers in cellular and infection microbiology JID - 101585359 SB - IM MH - Humans MH - Sensitivity and Specificity MH - *Molecular Diagnostic Techniques/methods/economics MH - *Polymerase Chain Reaction/methods/economics MH - *Diarrhea/diagnosis/virology/microbiology MH - Campylobacter jejuni/isolation & purification/genetics MH - Feces/virology/microbiology MH - Rotavirus/isolation & purification/genetics MH - Vibrio cholerae/isolation & purification/genetics MH - Shigella/isolation & purification/genetics MH - Rapid Diagnostic Tests PMC - PMC13337639 OTO - NOTNLM OT - closed-tube assay OT - co-infection detection OT - enteric pathogens OT - invasive reaction OT - rapid and low-cost detection COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/08 06:52 MHDA- 2026/07/08 20:04 PMCR- 2026/06/23 CRDT- 2026/07/08 04:40 PHST- 2026/03/28 00:00 [received] PHST- 2026/05/31 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/08 20:04 [medline] PHST- 2026/07/08 06:52 [pubmed] PHST- 2026/07/08 04:40 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.3389/fcimb.2026.1841155 [doi] PST - epublish SO - Front Cell Infect Microbiol. 2026 Jun 23;16:1841155. doi: 10.3389/fcimb.2026.1841155. eCollection 2026. PMID- 42415596 OWN - NLM STAT- Publisher LR - 20260708 IS - 1540-8159 (Electronic) IS - 0147-8389 (Linking) DP - 2026 Jul 8 TI - Internal Jugular Vein as an Alternative Access for Pacemaker Implantation: A Mostly Left IJ Case Series. LID - 10.1111/pace.70358 [doi] AB - BACKGROUND: Leadless pacemakers traditionally rely on femoral venous access, which may be limited in patients with unfavorable IVC anatomy, prior interventions, or situations where preserving femoral access is preferred. Internal jugular (IJ) access offers an alternative route, but real-world data on IJ implantation of single- and dual-chamber leadless devices remain limited. OBJECTIVE: To describe patient characteristics, procedural details, and outcomes of pacemaker implantation via IJ access. METHODS: We performed a retrospective case series of five patients who underwent Abbott Aveir leadless pacemaker implantation-ventricular (VR), atrial (AR), or dual-chamber-via right and left IJ access at a single center. Demographics, indications, rationale for IJ access, procedural course, and acute device parameters were reviewed. Outcomes included procedural success, access-related complications, and device performance at discharge. RESULTS: All five patients (mean age 41+/- 21 years; 40% female; BMI 25.9 +/- 6.7 kg/m(2)) underwent successful IJ access implantation. Indications for pacemaker included intermittent complete heart block (n = 1), sinus node dysfunction (n = 4). Reasons for selecting IJ access included avoidance of femoral access in young active patients (n = 2), complex IVC anatomy with failed femoral advancement (n = 1), improved sheath control and trajectory for atrial leadless deployment (n = 1), and concern that patient could not tolerate post procedure precautions due to neurocognitive disorder. Acute device performance was favorable. VR devices demonstrated pacing thresholds 0.25-1.0 V @ 0.4 ms, R-wave amplitudes 8.9-17.9 mV, and impedance 410-910 Omega. AR devices showed thresholds 0.75-5.0 V @ 0.4 ms, P-wave amplitudes 0.5-4.4 mV, and impedance 320-910 Omega. Dual-chamber systems had stable parameters in both chambers. There were no intraprocedural or access-related complications, including no pneumothorax, hematoma, venous thrombosis, embolization, or hemodynamic instability. All patients had stable device function at discharge. CONCLUSION: IJ vein access is a feasible and safe alternative for pacemaker implantation in patients with limited femoral access, including pediatric and complex adult populations. This approach allows effective device placement and stable pacing outcomes, avoiding femoral-related vascular complications. Further studies are needed to validate reproducibility and long-term performance. CI - (c) 2026 The Author(s). Pacing and Clinical Electrophysiology published by Wiley Periodicals LLC. FAU - Takagi, Maya Asami AU - Takagi MA AUID- ORCID: 0000-0003-0032-1130 AD - Department of Internal Medicine, University of California Davis Health System, Sacramento, California, USA. FAU - Leon, William AU - Leon W AD - Division of Cardiovascular Medicine, University of California Davis Health System, Sacramento, California, USA. FAU - Mackenzie, Colin AU - Mackenzie C AD - Division of Cardiovascular Medicine, University of California Davis Health System, Sacramento, California, USA. FAU - Cortez, Daniel AU - Cortez D AUID- ORCID: 0000-0001-9874-0733 AD - Division of Pediatric Cardiology, University of California Davis Health System, Sacramento, California, USA. LA - eng PT - Journal Article DEP - 20260708 PL - United States TA - Pacing Clin Electrophysiol JT - Pacing and clinical electrophysiology : PACE JID - 7803944 SB - IM OTO - NOTNLM OT - Aveir pacemaker OT - alternative venous access OT - cardiac pacing OT - internal jugular vein OT - leadless pacemaker EDAT- 2026/07/08 06:52 MHDA- 2026/07/08 06:52 CRDT- 2026/07/08 03:13 PHST- 2026/06/05 00:00 [revised] PHST- 2026/04/27 00:00 [received] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/07/08 06:52 [medline] PHST- 2026/07/08 06:52 [pubmed] PHST- 2026/07/08 03:13 [entrez] AID - 10.1111/pace.70358 [doi] PST - aheadofprint SO - Pacing Clin Electrophysiol. 2026 Jul 8. doi: 10.1111/pace.70358. PMID- 42415218 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260910 LR - 20260911 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2026 Jul 7 TI - Prevalence and clinical correlates of avoidant/restrictive food intake disorder in children and adolescents with Celiac disease: a cross-sectional study. LID - 10.1186/s40337-026-01699-3 [doi] LID - 212 AB - BACKGROUND: Avoidant/Restrictive Food Intake Disorder (ARFID) may represent a clinically important problem in celiac disease (CD), where lifelong dietary restriction, ongoing gastrointestinal symptoms, and food-related anxiety may promote food avoidance beyond gluten-containing foods and contribute to maladaptive eating patterns. Although adult studies have reported high rates of ARFID symptoms in CD, pediatric data are limited. This study aimed to evaluate the prevalence and clinical correlates of ARFID in children and adolescents with CD using a multidisciplinary assessment approach involving pediatric gastroenterology and child and adolescent psychiatry specialists, including anthropometric, nutritional, bone health, psychological, and health-related quality-of-life (QoL) correlates. METHODS: A cross-sectional study was conducted at a tertiary-care center involving children and adolescents aged 8-17 years with biopsy-confirmed CD (n = 101). Participants were assessed using a combination of clinical interviews and psychometric scales, including the Nine Item ARFID Screen (NIAS), the Revised Child Anxiety and Depression Scale (RCADS), and the Pediatric QoL Inventory (PedsQL). ARFID diagnosis was established through a DSM-5-guided clinical evaluation by two child and adolescent psychiatrists, and clinical and anthropometric data were collected alongside laboratory results. Multivariable regression models were used to identify factors independently associated with ARFID and clinical outcomes. RESULTS: The prevalence of ARFID in the cohort was 42.6%. Children with ARFID exhibited significantly lower weight and BMI z-scores (p < 0.001 and p = 0.002, respectively), a higher prevalence of osteopenia/osteoporosis (p = 0.005) and micronutrient deficiencies (p < 0.001), poorer QoL (p < 0.001), and higher anxiety and depressive symptom scores (p < 0.001 and p = 0.003, respectively). Presence of gastrointestinal symptoms and higher anxiety score were independently associated with ARFID in children and adolescents with CD. CONCLUSION: In this cohort, ARFID appeared to be a clinically relevant comorbidity in pediatric CD, with adverse physical and psychosocial correlates. Restrictive eating extending beyond gluten avoidance should be recognized during clinical assessment, particularly in children with gastrointestinal symptoms, prominent anxiety symptoms, poor weight gain, or persistent micronutrient deficiencies. Longitudinal studies are needed to clarify the clinical course of ARFID symptoms and to inform targeted multidisciplinary care in this population. CI - (c) 2026. The Author(s). FAU - Teke, Halenur AU - Teke H AUID- ORCID: 0009-0001-0143-3890 AD - Department of Child and Adolescent Psychiatry, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. drhalenurteke@gmail.com. FAU - Sogut, Aydan AU - Sogut A AD - Department of Child and Adolescent Psychiatry, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Mavi, Hilal Tuter AU - Mavi HT AD - Department of Child and Adolescent Psychiatry, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Teke, Selcuk AU - Teke S AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Ergen, Yasin Maruf AU - Ergen YM AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Akcay, Birce Izgi AU - Akcay BI AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Celebi, Seda Bozduman AU - Celebi SB AD - Department of Child and Adolescent Psychiatry, Basaksehir Cam ve Sakura City Hospital, Istanbul, Turkiye. FAU - Congologlu, Mehmet Ayhan AU - Congologlu MA AD - Department of Child and Adolescent Psychiatry, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. FAU - Balamtekin, Necati AU - Balamtekin N AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Gulhane Training and Research Hospital, University of Health Sciences, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260707 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC13556089 OAB - Celiac disease requires lifelong treatment with a strict gluten-free diet. In some children and adolescents, eating difficulties may extend beyond avoiding gluten and develop into avoidant/restrictive food intake disorder (ARFID), an eating disorder marked by very limited eating that is not driven by body image concerns. In celiac disease, ongoing digestive symptoms, fear of symptoms after gluten exposure, and the burden of following a strict diet may increase vulnerability to this problem. This study examined how common ARFID was in young people with celiac disease and explored its clinical features. ARFID was identified in 42.6% of the study group. Children and adolescents with ARFID had lower weight, more nutritional problems, weaker bone health, more anxiety and depression symptoms, and lower quality of life than those without ARFID. Ongoing gastrointestinal symptoms and higher anxiety symptoms were the factors most strongly linked with ARFID. These findings suggest that when food restriction extends beyond medically necessary dietary rules, it may indicate a more serious eating problem with both physical and emotional effects. Care for young people with celiac disease may benefit from a multidisciplinary approach that includes pediatric gastroenterology, child and adolescent psychiatry, dietetics, and psychological support. OABL- eng OTO - NOTNLM OT - Anxiety OT - Avoidant/Restrictive food intake disorder (ARFID) OT - Bone mineral density OT - Gluten-free diet OT - Pediatric celiac disease COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Scientific Research Ethics Committee of the University of Health Sciences, Gulhane Training and Research Hospital (Decision No: 2025/182, Decision Date: 11.09.2025). Written informed consent was obtained from all participants and their parents or legal guardians after providing a comprehensive explanation of the study aims and procedures. All study procedures adhered to the ethical standards set forth in the Declaration of Helsinki. Competing interests: The authors declare no competing interests. EDAT- 2026/07/08 02:00 MHDA- 2026/07/08 02:01 PMCR- 2026/07/07 CRDT- 2026/07/08 00:00 PHST- 2026/03/17 00:00 [received] PHST- 2026/06/27 00:00 [accepted] PHST- 2026/07/08 02:01 [medline] PHST- 2026/07/08 02:00 [pubmed] PHST- 2026/07/08 00:00 [entrez] PHST- 2026/07/07 00:00 [pmc-release] AID - 10.1186/s40337-026-01699-3 [pii] AID - 1699 [pii] AID - 10.1186/s40337-026-01699-3 [doi] PST - epublish SO - J Eat Disord. 2026 Jul 7;14(1):212. doi: 10.1186/s40337-026-01699-3. PMID- 42414927 OWN - NLM STAT- MEDLINE DCOM- 20261026 LR - 20261028 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 7 TI - A randomized clinical trial comparing the efficacy of probiotic drops and sucrose in managing colic in early infancy. LID - 10.1186/s12887-026-07271-x [doi] LID - 1057 AB - BACKGROUND AND AIM: Infantile colic, characterized by prolonged crying episodes in otherwise healthy infants, affects 10-40% of babies worldwide. Although self-limiting, it causes significant caregiver distress and disrupts infant development. Probiotics may alleviate colic symptoms by modulating gut microbiota and reducing inflammation, while sucrose has been shown to reduce crying by activating endogenous opioid pathways. This randomized controlled trial (RCT) compared the efficacy of Pedilact probiotic drops versus a 20% sucrose solution in managing colic. METHODS: A total of 120 breastfed infants aged 1-5 months with colic were randomly assigned to receive either Pedilact drops or 20% sucrose solution. Primary outcomes (feeding duration, crying hours, and sleep duration) were assessed at baseline and after 14 and 21 days of treatment. RESULTS: Significant differences were observed between the two groups in feeding duration, crying hours, and sleep duration at the 14- and 21-day follow-ups. However, both groups showed similar trends of improvement over time. Repeated measures ANOVA confirmed significant between-group differences in these outcomes, while the progression of improvement was identical in both groups. CONCLUSION: This study provides preliminary evidence that Pedilact probiotic drops may serve as a safe and natural complementary therapy for reducing colic symptoms compared to sucrose alone. However, larger blinded trials are needed to validate these findings and address limitations such as reliance on parental reporting. TRIAL REGISTRATION: This study was IRCT registration number: IRCT20230625058574N1 (Registration date: 2023-07-27). CI - (c) 2026. The Author(s). FAU - Zaker Tavallaie, Fateme AU - Zaker Tavallaie F AUID- ORCID: 0000-0003-3375-0863 AD - Department of Pediatrics, School of Medicine Heshmatie Hospital, Sabzevar University of Medical Sciences, Sabzevar, Iran. FAU - Aldaghi, Mitra Azra AU - Aldaghi MA AD - Department of Gastroenterology Pediatrics, Sabzevar University of Medical Sciences, Sabzevar, Iran. FAU - Rasti Sani, Seyedmorteza AU - Rasti Sani S AD - Department of Pediatrics, School of Medicine Heshmatie Hospital, Sabzevar University of Medical Sciences, Sabzevar, Iran. FAU - Amiri, Parastoo AU - Amiri P AUID- ORCID: 0000-0002-3085-8652 AD - Clinical Research Development Unit, Vasei Hospital, Sabzevar University of Medical Sciences, Sabzevar, Iran. FAU - Hassanpour, Kazem AU - Hassanpour K AUID- ORCID: 0000-0001-6281-2571 AD - Department of Gastroenterology Pediatrics, Sabzevar University of Medical Sciences, Sabzevar, Iran. drhassanpour@yahoo.com. FAU - Raeesi, Neda AU - Raeesi N AD - Department of Gastroenterology Pediatrics, Sabzevar University of Medical Sciences, Sabzevar, Iran. LA - eng GR - 401204/Sabzevar University of Medical Sciences/ PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20260707 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 57-50-1 (Sucrose) SB - IM MH - Humans MH - *Colic/therapy/drug therapy MH - *Probiotics/therapeutic use MH - Infant MH - *Sucrose/therapeutic use/administration & dosage MH - Crying MH - Female MH - Male MH - Treatment Outcome MH - Sleep Duration MH - Breast Feeding PMC - PMC13700407 OTO - NOTNLM OT - Crying time OT - Infantile colic; Probiotics OT - Sleep duration OT - Sucrose COIS- Declarations. Ethics approval and consent to participate: This study was performed in line with the principles of the Declaration of Helsinki and its later amendments. This study was approved by the research council and Ethics Committee of Sabzevar University of Medical Sciences, Sabzevar, Iran. Written informed consents were obtained from all study participants' parents or other legal guardians. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/08 02:07 MHDA- 2026/10/26 05:30 PMCR- 2026/07/07 CRDT- 2026/07/07 23:46 PHST- 2025/05/27 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/10/26 05:30 [medline] PHST- 2026/07/08 02:07 [pubmed] PHST- 2026/07/07 23:46 [entrez] PHST- 2026/07/07 00:00 [pmc-release] AID - 10.1186/s12887-026-07271-x [pii] AID - 7271 [pii] AID - 10.1186/s12887-026-07271-x [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 7;26(1):1057. doi: 10.1186/s12887-026-07271-x. PMID- 42413912 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260925 IS - 1543-5474 (Electronic) IS - 1543-3080 (Linking) VI - 23 IP - 10 DP - 2026 Oct 1 TI - Are Active Schools Associated With Active Commuting? Examining the Prevalence and Determinants in Young People. PG - 1444-1452 LID - 10.1123/jpah.2025-0724 [doi] AB - BACKGROUND: This study aimed to determine the prevalence of active commuting to school among children and adolescents in the Valencian Community (Spain) and to examine potential differences according to sociodemographic, institutional, and behavioral variables. METHODS: A total of 2232 students (8-18 y; 52.2% girls) from 20 schools participated. Sociodemographic (gender, educational stage, socioeconomic status), environmental (type of school: Active vs Non-Active), and behavioral (physical activity levels) variables were assessed using validated self-report instruments. Descriptive and bivariate analyses were conducted using Rao-Scott-adjusted chi-square tests for complex samples, and associations between commuting modes and study variables were subsequently examined using cluster-adjusted generalized estimating equations. RESULTS: Overall, 69% of students actively commuted to and from school. Significant differences were observed by gender and socioeconomic status, whereas no differences were found by educational stage, school type, or physical activity level. When commuting modes were examined, walking was the predominant behavior while cycling was rare (1.3%). Boys and students from lower-income households were more likely to walk, and boys were also more likely than girls to cycle. CONCLUSIONS: The study reveals that most students engage in active commuting to school, mainly by walking, although significant disparities persist according to sociodemographic variables. These findings highlight the need for future research to explore the specific barriers and facilitators of active commuting to school in young people, particularly among girls. They also support the implementation and systematic evaluation of school-based strategies designed to reduce these disparities and promote active, healthy, and sustainable mobility within the school. FAU - Sanchis-Frances, Lucia AU - Sanchis-Frances L AUID- ORCID: 0009-0008-9197-480X AD - Universitat de Valencia, Valencia, Spain. FAU - Valencia-Peris, Alexandra AU - Valencia-Peris A AUID- ORCID: 0000-0002-2031-9743 AD - Universitat de Valencia, Valencia, Spain. FAU - Ferriz, Roberto AU - Ferriz R AUID- ORCID: 0000-0001-7041-4098 AD - Universitat de Valencia, Valencia, Spain. FAU - Lizandra, Jorge AU - Lizandra J AUID- ORCID: 0000-0001-5599-133X AD - Universitat de Valencia, Valencia, Spain. LA - eng PT - Journal Article DEP - 20260707 PL - United States TA - J Phys Act Health JT - Journal of physical activity & health JID - 101189457 SB - IM MH - Humans MH - Female MH - Adolescent MH - *Transportation/methods/statistics & numerical data MH - Male MH - Child MH - *Bicycling/statistics & numerical data MH - Walking/statistics & numerical data MH - *Schools/statistics & numerical data MH - Spain MH - Socioeconomic Factors MH - Students/statistics & numerical data MH - *Exercise MH - Sex Factors MH - Sociodemographic Factors OTO - NOTNLM OT - active transport OT - physical activity OT - program evaluation OT - youth EDAT- 2026/07/08 01:48 MHDA- 2026/09/25 17:32 CRDT- 2026/07/07 19:33 PHST- 2025/09/25 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/05/02 00:00 [accepted] PHST- 2026/09/25 17:32 [medline] PHST- 2026/07/08 01:48 [pubmed] PHST- 2026/07/07 19:33 [entrez] AID - 10.1123/jpah.2025-0724 [doi] PST - epublish SO - J Phys Act Health. 2026 Jul 7;23(10):1444-1452. doi: 10.1123/jpah.2025-0724. Print 2026 Oct 1. PMID- 42413906 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260729 IS - 1543-2920 (Electronic) IS - 0899-8493 (Linking) VI - 38 IP - 3 DP - 2026 Aug 1 TI - Finding the Goldilocks Zone for Toddler Accelerometry: How Many Days Are Needed for a Reliable Estimate of Physical Activity and Sedentary Time Using Machine Learning? PG - 293-298 LID - 10.1123/pes.2025-0147 [doi] AB - PURPOSE: To understand how many days and hours per day of accelerometer wear are needed for a reliable estimation of sedentary time and physical activity (PA) using machine learning (ML). METHOD: One hundred and nine toddlers wore an accelerometer on the right hip at home for 7 days. Time in sedentary time, light PA, moderate to vigorous PA, and total PA were assessed using a validated ML model for toddlers. Single-day intraclass coefficients were calculated for each minimum hours per day of wear time and each outcome. These intraclass coefficients were passed to the Spearman-Brown prophecy equation to determine the reliability of each hour per day and days combination (3-12 h, 1-10 d). RESULTS: Predicted reliabilities ranged from 0.32 to 0.98, increasing as both numbers of hours per day and number of days increased. Four days of 6 hours of wear balances a 0.7 reliability threshold while retaining 94% of participants. CONCLUSION: Our findings support the recommended 6 hours per day of wear for at least 4 days, as it balances acceptable reliability with participant retention. This recommendation is valid for this ML method, and we anticipate that it can be used to further explore sedentary time and PA in toddlers using ML advances. FAU - Letts, Elyse AU - Letts E AUID- ORCID: 0000-0002-2543-8346 AD - Department of Pediatrics, Child Health & Exercise Medicine Program, McMaster University,Hamilton, ON,Canada. FAU - da Silva, Sarah M AU - da Silva SM AUID- ORCID: 0009-0001-9512-9776 AD - Department of Pediatrics, Child Health & Exercise Medicine Program, McMaster University,Hamilton, ON,Canada. FAU - King-Dowling, Sara AU - King-Dowling S AUID- ORCID: 0000-0003-3670-8425 AD - Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA,USA. FAU - Di Cristofaro, Natascja AU - Di Cristofaro N AD - Department of Pediatrics, Child Health & Exercise Medicine Program, McMaster University,Hamilton, ON,Canada. FAU - Obeid, Joyce AU - Obeid J AUID- ORCID: 0000-0002-6209-1505 AD - Department of Pediatrics, Child Health & Exercise Medicine Program, McMaster University,Hamilton, ON,Canada. AD - Department of Kinesiology, McMaster University,Hamilton, ON,Canada. LA - eng PT - Journal Article DEP - 20260707 PL - United States TA - Pediatr Exerc Sci JT - Pediatric exercise science JID - 8909729 SB - IM MH - Humans MH - *Accelerometry/methods MH - *Sedentary Behavior MH - Reproducibility of Results MH - *Machine Learning MH - Male MH - Female MH - *Exercise MH - Time Factors MH - Child, Preschool OTO - NOTNLM OT - actigraphy OT - early years OT - reliability EDAT- 2026/07/08 01:49 MHDA- 2026/07/29 13:54 CRDT- 2026/07/07 19:32 PHST- 2025/11/05 00:00 [received] PHST- 2026/02/04 00:00 [revised] PHST- 2026/02/11 00:00 [accepted] PHST- 2026/07/29 13:54 [medline] PHST- 2026/07/08 01:49 [pubmed] PHST- 2026/07/07 19:32 [entrez] AID - 10.1123/pes.2025-0147 [doi] PST - epublish SO - Pediatr Exerc Sci. 2026 Jul 7;38(3):293-298. doi: 10.1123/pes.2025-0147. Print 2026 Aug 1. PMID- 42413822 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260902 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 124 IP - 3 DP - 2026 Sep TI - Integrating executive function training with health behavior intervention for preschool obesity prevention in China: a cluster-randomized controlled trial. PG - 101427 LID - S0002-9165(26)00236-4 [pii] LID - 10.1016/j.ajcnut.2026.101427 [doi] AB - BACKGROUND: Preschool is a critical period for obesity prevention. However, few real-world interventions have integrated executive function (EF) enhancing activities with health behavior promotion. OBJECTIVES: To evaluated the effectiveness of a multilevel kindergarten-family intervention among preschoolers in China. METHODS: In this cluster-randomized controlled trial, 26 kindergartens in Wuhan were stratified by kindergarten educational tier and randomly assigned (1:1) to either the intervention or control group. The intervention comprised health education, EF-enhancing activities, environmental modifications, and family engagement strategies over 3 semesters. The primary outcome was change in body mass index z-score (BMIz); secondary outcomes included EF performance and health behaviors. Linear mixed models accounted for clustering and repeated measures; a bias-reduced linearization (CR2) cluster-robust small-sample-corrected sensitivity analysis was conducted. RESULTS: Of 1239 children included, 638 were assigned to the intervention group and 601 to the control group; 21.2% were classified as having overweight or obesity at baseline. In the primary analysis, BMIz gain was smaller in the interventions than in controls [mean difference (MD), -0.08; P = 0.043]. EF performance improved at midline in Digit Span Test 1 (MD: 0.28; P = 0.002), Digit Span Test 2 (MD: 0.23; P = 0.15), and Corsi Block Tapping Test 2 (MD: 0.41; P < 0.001). At the endpoint, the simplified Stroop day-night task showed a nominal improvement (MD: 0.48; P = 0.009). The healthy dietary consumption scores changed favorably (MD: -0.73; P = 0.017). Exploratory subgroup analyses suggested possible heterogeneity by kindergarten tier at midline (P for interaction = 0.086) and by sex at endpoint (P for interaction = 0.052), with a larger estimated endline effect among boys. CONCLUSIONS: This kindergarten-family intervention showed directionally favorable but statistically uncertain effects on BMIz gain after small-sample correction, alongside modest improvements in selected EF outcomes. These findings support the feasibility and potential promise of this approach for early obesity prevention, whereas larger trials are needed to confirm effectiveness, durability, and equity across settings. The trial was registered at the Chinese Clinical Trial Registry as ChiCTR2200058452 (9 April, 2022; https://www.chictr.org.cn/hvshowproject.html?id=205233&v=1.1). CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Wang, Miyuan AU - Wang M AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Xia, Wenqi AU - Xia W AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Xu, Ke AU - Xu K AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Evidence-based Nursing Center, West China Hospital, Sichuan University, Chengdu, China. FAU - Chen, Fengyan AU - Chen F AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Wang, Yimin AU - Wang Y AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Wei, Mengna AU - Wei M AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Deng, Weixi AU - Deng W AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Zheng, Xinyi AU - Zheng X AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Zhang, Zengzhen AU - Zhang Z AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Xiong, Jinrui AU - Xiong J AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Wang, Lingyu AU - Wang L AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Lin, Yuxin AU - Lin Y AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Wang, Youfa AU - Wang Y AD - Global Health Institute, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an City, China. FAU - Zhang, Jianduan AU - Zhang J AD - Department of Maternal and Child Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Environment and Health, Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: jd_zh@hust.edu.cn. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260707 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - *Executive Function MH - Child, Preschool MH - Male MH - China MH - *Pediatric Obesity/prevention & control MH - Female MH - *Health Behavior MH - Body Mass Index MH - *Health Promotion OTO - NOTNLM OT - childhood obesity OT - cluster-randomized control trial OT - energy balance-related behavior OT - executive function OT - preschool intervention COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/07/08 01:43 MHDA- 2026/09/01 23:34 CRDT- 2026/07/07 19:14 PHST- 2026/03/18 00:00 [received] PHST- 2026/06/28 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/09/01 23:34 [medline] PHST- 2026/07/08 01:43 [pubmed] PHST- 2026/07/07 19:14 [entrez] AID - S0002-9165(26)00236-4 [pii] AID - 10.1016/j.ajcnut.2026.101427 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Sep;124(3):101427. doi: 10.1016/j.ajcnut.2026.101427. Epub 2026 Jul 7. PMID- 42412896 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 7 DP - 2026 TI - Longitudinal associations of academic stress with eating related patterns, nutrition, somatic indicators, and depressive symptoms in university students: A study protocol. PG - e0352779 LID - 10.1371/journal.pone.0352779 [doi] LID - e0352779 AB - INTRODUCTION: Academic stress (AS) can be understood as a multidimensional form of chronic stress that has been linked to adverse patterns across physical and mental health in university students. This protocol outlines a longitudinal, observational study to examine within-semester associations between AS and indicators of nutritional status, eating-related patterns, sleep quality, and depressive symptoms. By integrating physiological, behavioral, and psychological indicators within a repeated-measures framework, the study aims to generate evidence that can inform prevention-focused actions and early support strategies in university health contexts. HYPOTHESES: (i) Higher AS will be longitudinally associated with less favorable eating-related patterns, nutritional and somatic indicators, and higher depressive symptoms in university students. (ii) Higher AS will be associated with altered post-awakening cortisol dynamics, specifically a lower cortisol awakening response (CAR) and lower AUCi, together with a higher AUCg, and with higher salivary alpha-amylase (sAA) levels, consistent with stress-related activation of HPA-axis and sympathetic pathways. DESIGN AND PARTICIPANTS: A longitudinal, observational, nonexperimental design with repeated measurements will be implemented across three assessment cycles during an academic semester. A feasibility-based convenience sample will be recruited from undergraduate students (2nd to 4th year) enrolled in the Faculty of Medicine, University of Concepcion (Chile). Students receiving psychological or pharmacological treatment will be eligible to reflect real-world heterogeneity and support ecological validity. METHODS: Data will be collected through standardized questionnaires, nutritional assessments, biological sampling, and wearable-derived somatic indicators. Electronic surveys administered via REDCap will assess AS, perceived stress, eating-related patterns, and depressive symptoms. Diet will be assessed through interviewer-administered nutritional interviews, including repeated 24-hour dietary recalls treated as time-specific observations and modeled longitudinally as time-varying measures, and complemented by diet-quality and dietary inflammatory potential indices. Wearable devices will record nonclinical somatic indicators, including heart rate, oxygen saturation, and sleep-related metrics during monitoring periods. Saliva will be collected twice per week during each assessment cycle to quantify salivary cortisol dynamics and sAA activity, and peripheral blood samples obtained at baseline and end of semester will be used to determine lipid profile, fasting glucose, albumin, globulin, and total proteins. STATISTICAL ANALYSIS: Analyses will include descriptive and bivariate summaries, followed by multivariable models appropriate to outcome type. Longitudinal associations will be examined using mixed-effects models, and temporal cross-lagged associations will be explored using random-intercept cross-lagged panel models across the three assessment cycles. All inferences will be framed as associational given the observational design. EXPECTED RESULTS: Rather than prespecifying outcomes, this protocol is expected to generate longitudinal evidence on how within-semester variation in AS aligns with eating-related patterns, diet, nutritional and somatic indicators, depressive symptoms, and stress-related physiological indicators (salivary cortisol dynamics and sAA activity). The integrated, feasibility-oriented measurement framework may serve as a replicable template for future research and inform prevention-focused actions to support student well-being in university settings. CI - Copyright: (c) 2026 Rojas-Cardenas et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Rojas-Cardenas, Pia AU - Rojas-Cardenas P AUID- ORCID: 0000-0002-6208-0830 AD - Programa de Doctorado en Salud Mental, Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile. AD - Carrera de Nutricion y Dietetica, Facultad de Ciencias de la Salud, Universidad Adventista de Chile, Nuble, Chile. FAU - Nazar, Gabriela AU - Nazar G AD - Departamento de Psicologia, Facultad de Ciencias Sociales, Universidad de Concepcion, Concepcion, Chile. FAU - Castillo-Navarrete, Juan Luis AU - Castillo-Navarrete JL AUID- ORCID: 0000-0002-7401-2384 AD - Programa de Doctorado en Salud Mental, Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile. AD - Departamento de Tecnologia Medica, Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile. AD - Programa de Neurociencia, Psiquiatria y Salud Mental, NEPSAM, Universidad de Concepcion, Concepcion, Chile. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260707 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - WI4X0X7BPJ (Hydrocortisone) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - Cortisol Awakening Response MH - *Depression/psychology/physiopathology MH - *Feeding Behavior/psychology MH - Hydrocortisone/metabolism MH - Longitudinal Studies MH - *Nutritional Status MH - Saliva/metabolism MH - Sleep Quality MH - *Stress, Psychological/psychology/physiopathology/metabolism MH - *Students/psychology MH - Universities MH - Observational Studies as Topic PMC - PMC13340845 COIS- The authors declare no competing interests. Funding was provided by Agencia Nacional de Investigacion y Desarrollo (ANID), Chile: FONDECYT Iniciacion No. 11240383 (recipient: Juan Luis Castillo-Navarrete) and ANID Doctoral Scholarship No. 1340/2025 (recipient: Pia Rojas-Cardenas). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. EDAT- 2026/07/08 01:10 MHDA- 2026/07/08 01:11 PMCR- 2026/07/07 CRDT- 2026/07/07 13:43 PHST- 2025/12/18 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/07/08 01:11 [medline] PHST- 2026/07/08 01:10 [pubmed] PHST- 2026/07/07 13:43 [entrez] PHST- 2026/07/07 00:00 [pmc-release] AID - PONE-D-25-67135 [pii] AID - 10.1371/journal.pone.0352779 [doi] PST - epublish SO - PLoS One. 2026 Jul 7;21(7):e0352779. doi: 10.1371/journal.pone.0352779. eCollection 2026. PMID- 42412396 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1440-172X (Electronic) IS - 1322-7114 (Print) IS - 1322-7114 (Linking) VI - 32 IP - 4 DP - 2026 Aug TI - Validity of the Translated Turkish Version of the Tool for Nutrition Risk Screening for Paediatric Cancer. PG - e70168 LID - 10.1111/ijn.70168 [doi] LID - e70168 AB - BACKGROUND: Malnutrition in paediatric cancer patients increases adverse clinical outcomes; however, methods for assessing malnutrition risk remain unclear. This study aimed to assess the validity of the Nutrition Risk Screening for Pediatric Cancer (NRS-PC). METHODS: This cross-sectional study was conducted in the paediatric oncology unit of a tertiary care university hospital. The nutritional risk and malnutrition status were assessed by the Nutrition Screening Tool for Childhood Cancer (SCAN) and Pediatric Subjective Global Nutritional Assessment (SGNA), respectively. Receiver-operator characteristic (ROC) curve method was used to evaluate the validity of NRS-PC. Sensitivity, specificity, positive and negative predictive values were calculated. RESULTS: The median age of children was 8 years, and 60.2% were boys. The prevalence of malnutrition was 48.4%. NRS-PC had excellent accuracy compared with SCAN (AUC: 0.87, 95% CI: 0.827-0.944; p < 0.001) and SGNA (AUC: 0.90, 95% CI: 0.847-0.951; p < 0.001). Using SGNA as a reference method, the NRS-PC tool had a sensitivity of 77.4%-100% and specificity of 24.2%-86.4% according to different cut-off points. CONCLUSION: The Turkish version of the NRS-PC is a simple, valid and practical method for nutritional risk screening in the paediatric oncology population. Further feasibility and acceptability studies are needed to determine the most appropriate screening tools in children. CI - (c) 2026 The Author(s). International Journal of Nursing Practice published by John Wiley & Sons Australia, Ltd. FAU - Meral, Buket AU - Meral B AUID- ORCID: 0000-0003-1664-9333 AD - Department of Child Health and Diseases Nursing, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, Turkey. FAU - Kangalgil, Melda AU - Kangalgil M AUID- ORCID: 0000-0003-2868-8903 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Sivas Cumhuriyet University, Sivas, Turkey. FAU - Erduran, Erol AU - Erduran E AD - Department of Pediatric Hematology and Oncology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkey. LA - eng PT - Journal Article PT - Validation Study PL - Australia TA - Int J Nurs Pract JT - International journal of nursing practice JID - 9613615 SB - IM MH - Humans MH - Turkey MH - Male MH - Child MH - Cross-Sectional Studies MH - Female MH - *Nutrition Assessment MH - *Neoplasms/complications MH - *Malnutrition/diagnosis MH - Child, Preschool MH - Risk Assessment MH - Nutritional Status PMC - PMC13340497 OTO - NOTNLM OT - malnutrition OT - nurses OT - nursing OT - nutritional assessment OT - paediatric oncology OT - sensitivity OT - specificity COIS- The authors declare no conflicts of interest. EDAT- 2026/07/07 12:34 MHDA- 2026/07/07 18:54 PMCR- 2026/07/07 CRDT- 2026/07/07 11:26 PHST- 2026/06/01 00:00 [revised] PHST- 2025/03/11 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/07/07 18:54 [medline] PHST- 2026/07/07 12:34 [pubmed] PHST- 2026/07/07 11:26 [entrez] PHST- 2026/07/07 00:00 [pmc-release] AID - IJN70168 [pii] AID - 10.1111/ijn.70168 [doi] PST - ppublish SO - Int J Nurs Pract. 2026 Aug;32(4):e70168. doi: 10.1111/ijn.70168. PMID- 42410484 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260930 LR - 20261002 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 12 IP - 1 DP - 2026 Jul 6 TI - Misreporting of energy intake estimated by food records among adolescents in Lao People's Democratic Republic: a cross-sectional study. LID - 10.1186/s40795-026-01416-y [doi] LID - 203 AB - BACKGROUND: Accurate dietary assessment data is vital for understanding dietary patterns and the associated nutrition and health outcomes. However, research on misreporting from self-reported dietary assessment tools has remained limited in low- and middle-income countries. Our study aims to investigate energy intake misreporting and its determinants among adolescents in Lao People's Democratic Republic (PDR). METHODS: We conducted a cross-sectional secondary analysis of seven-day estimated food records collected from 405 adolescents aged 10-18 years attending secondary schools in Vientiane Province, Lao PDR, between March and April 2019. We identified energy intake misreporting using the Goldberg cut-off method, and analyzed factors associated with energy intake underreporting using multivariable logistic regression analyses. We compared the percentage energy intake from each food group between plausible reporters and underreporters, using the Mann-Whitney U-test. RESULTS: Approximately 61.2% of participants underreported and 0.3% overreported their energy intake. Older adolescents (15-18 years) were 50% less likely to be classified as underreporters than younger adolescents (10-14 years) (Adjusted Odds Ratio [AOR] = 0.54, 95% CI: 0.34-0.88). Higher Body Mass Index was associated with higher odds of underreporting (AOR = 1.09, 95% CI: 1.01-1.18), whereas higher number of reported snacks between meals was associated with lower odds of underreporting (AOR = 0.81, 95% CI: 0.76-0.86). Underreporting increased over the seven-day period (51.4% on day 1 to 65.9% on day 7). CONCLUSIONS: This study highlights a high prevalence of energy intake underreporting among Lao PDR adolescents when using the seven-day estimated food record method. While this prospective method has advantages, its accuracy depends on sustained participant engagement and motivation. Future research is needed to develop, adapt and validate tools, such as technology-assisted tools, for use among adolescents in Lao PDR. CI - (c) 2026. The Author(s). FAU - Kounnavong, Thidatheb AU - Kounnavong T AUID- ORCID: 0009-0007-5614-6147 AD - School of Tropical Medicine and Global Health, Nagasaki University, 1 Chome-12-4 Sakamoto, Nagasaki, 852-8102, Japan. thidatheb.kounnavong@nagasaki-u.ac.jp. FAU - Moji, Kazuhiko AU - Moji K AD - School of Tropical Medicine and Global Health, Nagasaki University, 1 Chome-12-4 Sakamoto, Nagasaki, 852-8102, Japan. moji.k273@gmail.com. FAU - Sato, Miho AU - Sato M AD - School of Tropical Medicine and Global Health, Nagasaki University, 1 Chome-12-4 Sakamoto, Nagasaki, 852-8102, Japan. FAU - Turner, Christopher AU - Turner C AD - Food and Markets Department, Natural Resources Institute, University of Greenwich, London, UK. FAU - Vonglokham, Manithong AU - Vonglokham M AD - Department of Health Policy and Health System Research, Lao Tropical and Public Health Institute, Vientiane, Lao People's Democratic Republic. FAU - Ferguson, Elaine AU - Ferguson E AD - Department of Population Health, London School of Hygiene and Tropical Medicine, London, UK. LA - eng PT - Journal Article DEP - 20260706 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC13625445 OTO - NOTNLM OT - Adolescent OT - Cross sectional study OT - Dietary assessment OT - Energy intake OT - Food Record OT - Lao People's Democratic Republic OT - Misreporting OT - Technologies OT - Underreporting COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the principles of the Declaration of Helsinki. The study utilized secondary data collected as part of a separate project conducted by the Lao Tropical and Public Health Institute, which received ethical approval from the National Ethical Committee for Health Research of Lao PDR (Protocol No. 013/2019/NECHR). Informed consent was obtained from all adolescent participants and their legal guardians before the data were collected. The study strictly followed the relevant guidelines and regulations. The dataset is fully anonymized and de-identified, ensuring that no individual participants could be identified or traced. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/07 00:38 MHDA- 2026/07/07 00:39 PMCR- 2026/07/06 CRDT- 2026/07/07 00:00 PHST- 2026/03/18 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/07/07 00:39 [medline] PHST- 2026/07/07 00:38 [pubmed] PHST- 2026/07/07 00:00 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - 10.1186/s40795-026-01416-y [pii] AID - 1416 [pii] AID - 10.1186/s40795-026-01416-y [doi] PST - epublish SO - BMC Nutr. 2026 Jul 6;12(1):203. doi: 10.1186/s40795-026-01416-y. PMID- 42409680 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261009 IS - 1590-3729 (Electronic) IS - 0939-4753 (Linking) VI - 36 IP - 11 DP - 2026 Nov TI - Uric acid to high density lipoprotein-cholesterol ratio as a potential biomarker of comorbidities in youth with obesity. PG - 104847 LID - S0939-4753(26)00309-1 [pii] LID - 10.1016/j.numecd.2026.104847 [doi] AB - BACKGROUND AND AIM: The uric acid to high-density lipoprotein-cholesterol ratio (UHR) has been associated with type 2 diabetes or hepatic steatosis in adults, while pediatric evidence is poor. We aimed to evaluate the association between UHR and several obesity-related comorbidities in youths with overweight or obesity (OW/OB). METHODS AND RESULTS: 1215 youths of the CARITALY study were enrolled. Impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) were assessed by standard methods. The homeostasis model assessment of insulin resistance (HOMA-IR) and the whole-body insulin sensitivity index (WBISI) were calculated. A continuous cardiometabolic risk score (cCMR) was calculated. Metabolic-associated steatotic liver disease (MASLD) was defined by a standard method. Mild reduced-estimated glomerular filtration rate (MReGFR) was defined by eGFR value > 60 < 90 ml/min/1.73 m(2) White blood cell count (WBCc) was obtained. UHR was stratified into quartiles. Youths in the top UHR quartile showed a higher odds ratio (OR)(95%CI) of MReGFR: 2.03 (1.31-3.13) and cCMR: 2915 (1.60-4.24) vs the first quartile. Youths in the third UHR quartile showed significantly higher ORs of IFG 2.00 (1.01-3.94), IGT: 2.64 (1.37-5.10), HOMA-IR: 1.64 (1.17-2.29), and high WBCc: 2.49 (1.64-3.77), whereas youths yet in the second quartile showed significantly higher OR of low WBISI: 1.60 (1.04-2.50) and MASLD: 1.61 (1.13-2.28) vs the first quartile. CONCLUSIONS: UHR was associated with disrupted glucose homeostasis, high cardiometabolic risk, MASLD, reduced glomerular filtration, and low-grade inflammation in youths with OW/OB. UHR is a promising biomarker for detecting obesity-related comorbidities in this population. CI - Copyright (c) 2026 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved. FAU - Di Bonito, Procolo AU - Di Bonito P AD - Department of Internal Medicine, "S. Maria delle Grazie" Hospital, Pozzuoli, Italy. FAU - Umano, Giuseppina Rosaria AU - Umano GR AD - Department of the Woman, the Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy. FAU - Licenziati, Maria Rosaria AU - Licenziati MR AD - Neuro-Endocrine Diseases and Obesity Unit, Department of Neurosciences, Santobono-Pausilipon Children's Hospital, Naples, Italy. FAU - Corica, Domenico AU - Corica D AD - Department of Human Pathology of Adulthood and Childhood "G. Barresi", Pediatric Unit, University of Messina, Messina, Italy. FAU - Wasniewska, Malgorzata Gabriela AU - Wasniewska MG AD - Department of Human Pathology of Adulthood and Childhood "G. Barresi", Pediatric Unit, University of Messina, Messina, Italy. FAU - Morandi, Anita AU - Morandi A AD - Department of Surgery, Dentistry, Pediatrics and Gynecology, Section of Pediatric Diabetes and Metabolism, University and University Hospital of Verona, Verona, Italy. FAU - Maffeis, Claudio AU - Maffeis C AD - Department of Surgery, Dentistry, Pediatrics and Gynecology, Section of Pediatric Diabetes and Metabolism, University and University Hospital of Verona, Verona, Italy. FAU - Faienza, Maria Felicia AU - Faienza MF AD - Pediatric Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "A. Moro", Bari, Italy. FAU - Mozzillo, Enza AU - Mozzillo E AD - Department of Translational Medical Science, Section of Pediatrics, University of Naples "Federico II", Napoli, Italy. FAU - Calcaterra, Valeria AU - Calcaterra V AD - Pediatric Department, "V. Buzzi" Children's Hospital, Milano and Department of Internal Medicine, University of Pavia, Pavia, Italy. FAU - Franco, Francesca AU - Franco F AD - Pediatric Department, Azienda Sanitaria Universitaria del Friuli Centrale, Hospital of Udine, Udine, Italy. FAU - Maltoni, Giulio AU - Maltoni G AD - Pediatric Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy. FAU - Del Giudice, Emanuele Miraglia AU - Del Giudice EM AD - Department of the Woman, the Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy. FAU - Di Sessa, Anna AU - Di Sessa A AD - Department of the Woman, the Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy. FAU - Valerio, Giuliana AU - Valerio G AD - Department of Medical, Movement Sciences and Wellbeing, University of Napoli "Parthenope", Naples, Italy. Electronic address: giuliana.valerio@uniparthenope.it. LA - eng PT - Journal Article DEP - 20260616 PL - Netherlands TA - Nutr Metab Cardiovasc Dis JT - Nutrition, metabolism, and cardiovascular diseases : NMCD JID - 9111474 RN - 0 (Biomarkers) RN - 268B43MJ25 (Uric Acid) RN - 0 (Cholesterol, HDL) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Female MH - Male MH - Biomarkers/blood MH - *Uric Acid/blood MH - Adolescent MH - *Pediatric Obesity/diagnosis/epidemiology/blood MH - Child MH - Risk Assessment MH - Predictive Value of Tests MH - *Cholesterol, HDL/blood MH - Cross-Sectional Studies MH - Comorbidity MH - Italy/epidemiology MH - Age Factors MH - Cardiometabolic Risk Factors MH - Glomerular Filtration Rate MH - Blood Glucose/metabolism MH - Insulin Resistance MH - *Metabolic Syndrome/diagnosis/epidemiology/blood OTO - NOTNLM OT - Cardiometabolic risk OT - Metabolic-associated steatotic liver disease OT - Pediatric obesity OT - Prediabetes OT - Reduced glomerular filtration COIS- Declaration of competing interest The authors declared no conflict of interest. EDAT- 2026/07/07 04:11 MHDA- 2026/10/09 23:31 CRDT- 2026/07/06 21:52 PHST- 2025/07/12 00:00 [received] PHST- 2026/05/21 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/10/09 23:31 [medline] PHST- 2026/07/07 04:11 [pubmed] PHST- 2026/07/06 21:52 [entrez] AID - S0939-4753(26)00309-1 [pii] AID - 10.1016/j.numecd.2026.104847 [doi] PST - ppublish SO - Nutr Metab Cardiovasc Dis. 2026 Nov;36(11):104847. doi: 10.1016/j.numecd.2026.104847. Epub 2026 Jun 16. PMID- 42409604 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1369-1600 (Electronic) IS - 1355-6215 (Print) IS - 1355-6215 (Linking) VI - 31 IP - 7 DP - 2026 Jul TI - Effects of Different Exercise Intensities on Internet Addiction in Adolescents and Young Adults: A Systematic Review and Network Meta-Analysis. PG - e70172 LID - 10.1111/adb.70172 [doi] LID - e70172 AB - This study employed a network meta-analysis to evaluate and compare the efficacy of different exercise intensities (light, moderate and vigorous) on internet addiction and related psychological symptoms in adolescents and young adults. We systematically searched eight databases for relevant randomised controlled trials. A total of 22 studies with 1438 samples were included. A pairwise meta-analysis indicated that exercise interventions across all intensities were associated with improvements in internet addiction, anxiety and negative moods, with moderate-intensity additionally improving depression. The results of the network meta-analysis suggested that light-intensity exercise (SMD = -2.61, 95% CI [-4.29, -0.93], p = 0.002), moderate-intensity exercise (SMD = -2.74, 95% CI [-4.25, -1.22], p < 0.0001) and high-intensity exercise (SMD = -2.55, 95% CI [-4.88, -0.22], p = 0.032) may be associated with a reduction in adolescents' internet addiction. Only moderate-intensity exercise may be associated with a reduction in depression (SMD = -1.19, 95% CI [-2.20, -0.18], p = 0.021) and anxiety (SMD = -1.90, 95% CI [-3.50, -0.30], p = 0.02); light-intensity and high-intensity exercise were not significantly associated with a reduction in depression and anxiety. Light-intensity exercise (SMD = -1.63, 95% CI [-2.85, -0.41], p = 0.009) and moderate-intensity exercise (SMD = -1.55, 95% CI [-2.56, -0.54], p = 0.003) may be associated with reductions in other negative moods. According to the probability ranking of the likelihood of the optimal intervention effect, moderate-intensity exercise (SUCRA = 71) ranked highest for interventions in adolescents' internet addiction, depression (SUCRA = 70.2), anxiety (SUCRA = 68.4) and light exercise (SUCRA = 67.9) ranked highest for negative moods. However, owing to the limitations of sample size and the quality of individual studies, the strength of evidence needs to be further validated by more standardised, high-quality studies. CI - (c) 2026 The Author(s). Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction. FAU - Yu, Min AU - Yu M AD - School of Physical Education, Hunan University of Arts and Science, Changde, China. FAU - Chang, Yuanyuan AU - Chang Y AD - School of Physical Education and Health Engineering, Taiyuan University of Technology, Taiyuan, China. FAU - Kang, Haobo AU - Kang H AD - School of Physical Education and Health Engineering, Taiyuan University of Technology, Taiyuan, China. FAU - Mao, Wuyang AU - Mao W AD - School of Physical Education, Hunan University, Changsha, China. LA - eng GR - 25JGYB0441/Hunan Provincial Basic Education Teaching Reform Research Project/ PT - Journal Article PT - Network Meta-Analysis PT - Systematic Review PL - United States TA - Addict Biol JT - Addiction biology JID - 9604935 SB - IM MH - Adolescent MH - Humans MH - Young Adult MH - Anxiety/therapy/psychology MH - *Behavior, Addictive/therapy MH - Depression/therapy/psychology MH - *Exercise/psychology MH - Exercise Therapy/methods MH - Internet MH - *Internet Addiction Disorder/therapy/psychology PMC - PMC13337322 OTO - NOTNLM OT - anxiety OT - depression OT - exercise intensity OT - internet addiction OT - negative moods COIS- The authors declare no conflicts of interest. EDAT- 2026/07/07 00:39 MHDA- 2026/07/07 18:53 PMCR- 2026/07/06 CRDT- 2026/07/06 21:23 PHST- 2026/05/08 00:00 [revised] PHST- 2025/12/12 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/07/07 18:53 [medline] PHST- 2026/07/07 00:39 [pubmed] PHST- 2026/07/06 21:23 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - ADB70172 [pii] AID - 10.1111/adb.70172 [doi] PST - ppublish SO - Addict Biol. 2026 Jul;31(7):e70172. doi: 10.1111/adb.70172. PMID- 42406088 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261015 IS - 1437-1596 (Electronic) IS - 0937-9827 (Print) IS - 0937-9827 (Linking) VI - 140 IP - 6 DP - 2026 Nov TI - Diagnostic performance of Demirjian's third molar maturation stages G, G1, and H for identifying the 18-year age threshold: a sex-specific study. PG - 4435-4443 LID - 10.1007/s00414-026-03904-z [doi] AB - Determining attainment of 18 years is a critical task in forensic age estimation. This study evaluated and compared the sex-specific diagnostic performance of conventional and refined third-molar maturation cut-offs, Demirjian stages G and H, and the refined stage G1 for identifying individuals aged >/= 18 years in a South Indian population. Panoramic radiographs of 599 individuals aged 14-22 years were retrospectively assessed. Mandibular left third molars were staged using the conventional Demirjian system and the Solari and Abramovitch modification. Diagnostic performance was evaluated separately for males and females using sensitivity, specificity, predictive values, likelihood ratios, accuracy, and post-test probabilities. Intra- and inter-examiner agreement was assessed using kappa statistics. Third-molar maturation effectively discriminated attainment of 18 years in both sexes, with stage-dependent trade-offs between sensitivity and specificity. Stages G and above and stages G1 and above demonstrated high sensitivity and strong exclusion of adulthood when negative, whereas stage H showed higher specificity and greater confirmatory value when present, particularly among females. Diagnostic performance of the refined G1 stage was comparable to that of stage G, with modest improvement in specificity and post-test probability in females. Inter-examiner agreement was excellent for stages G and H but only moderate for G1, indicating reduced reproducibility for the refined stage. In conclusion, conventional Demirjian stages G and H remain reliable and reproducible indicators for assessing attainment of 18 years. Although the refined G1 stage offers increased developmental resolution and supports probabilistic interpretation, its forensic utility is constrained by reduced inter-observer agreement. CI - (c) 2026. The Author(s). FAU - Balla, Sudheer Babu AU - Balla SB AUID- ORCID: 0000-0003-0977-3889 AD - Department of Rural Clinical Sciences, La Trobe University, Bendigo, 3550, Australia. s.balla@latrobe.edu.au. FAU - Nagarakanti, Naga Madhuri AU - Nagarakanti NM AD - Government Medical College, Mahbubnagar, Telangana, India. FAU - Chinni, Subramanyeswara Swamy AU - Chinni SS AD - Clinical Practitioner, Chicago, USA. FAU - Shahnaz, Waheeda AU - Shahnaz W AD - SVS Institute of Dental Sciences, Mahabubnagar, Telangana, India. FAU - Bojji, Manasa AU - Bojji M AD - Malla Reddy Dental College for Women, Hyderabad., Telangana, India. FAU - Pacha, Venkat Baghirath AU - Pacha VB AD - Panineeya Institute of Dental Sciences & Research Center, Hyderabad, Telangana, India. LA - eng PT - Journal Article DEP - 20260706 PL - Germany TA - Int J Legal Med JT - International journal of legal medicine JID - 9101456 RN - Indian people SB - IM MH - Retrospective Studies MH - *Molar, Third/diagnostic imaging/growth & development MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - *Age Determination by Teeth/methods MH - Radiography, Panoramic MH - South Asian People PMC - PMC13658497 OTO - NOTNLM OT - Age of majority OT - Demirjian method OT - Dental age estimation OT - Diagnostic accuracy OT - Refined root stages OT - Third molar COIS- Declarations. Ethical standards: Yes. Ethics approval: Obtained. Research involving human participants, their data, or biological material: Radiographs were collected retrospectively from the archives. Human ethics and consent to participate: Not applicable. Competing interest: The authors declare no competing interests. EDAT- 2026/07/06 12:41 MHDA- 2026/10/12 17:30 PMCR- 2026/07/06 CRDT- 2026/07/06 11:15 PHST- 2026/04/04 00:00 [received] PHST- 2026/06/28 00:00 [accepted] PHST- 2026/10/12 17:30 [medline] PHST- 2026/07/06 12:41 [pubmed] PHST- 2026/07/06 11:15 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - 10.1007/s00414-026-03904-z [pii] AID - 3904 [pii] AID - 10.1007/s00414-026-03904-z [doi] PST - ppublish SO - Int J Legal Med. 2026 Nov;140(6):4435-4443. doi: 10.1007/s00414-026-03904-z. Epub 2026 Jul 6. PMID- 42405474 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 2051-817X (Electronic) IS - 2051-817X (Linking) VI - 14 IP - 13 DP - 2026 Jul TI - Free-living associations between resting heart rate parameters and cardiometabolic health in adults. PG - e71008 LID - 10.14814/phy2.71008 [doi] LID - e71008 AB - This study examined associations between multi-day ultra-short resting heart rate (HR) parameters and cardiometabolic health under free-living conditions. Sixty-seven adults (18-59 years, 53% male) completed seven consecutive days of seated 1-min RR interval recordings after waking using a validated chest strap monitor. Log-transformed root mean square of successive differences (LnRMSSD(M)) and resting HR (HR(M)) were averaged across days and standardized. Cardiometabolic health status was defined as the number of metabolic syndrome (MetS) components present. Associations were assessed using Poisson regression adjusted for age and sex, with additional models including HR(M) and HR-adjusted LnRMSSD. Higher LnRMSSD(M) was associated with fewer MetS components (IRR = 0.79, 95% CI: 0.64-0.97), whereas higher HR(M) was associated with greater metabolic burden (IRR = 1.40, 95% CI: 1.10-1.77). When both variables were included, the association between LnRMSSD(M) and MetS was attenuated and no longer significant (IRR = 0.93, 95% CI: 0.72-1.22), while HR(M) remained significant (IRR = 1.33, 95% CI: 1.00-1.77). Resting HR parameters obtained through accessible devices were associated with cardiometabolic health, with resting HR accounting for much of the cross-sectional information captured by LnRMSSD. Remote cardiac monitoring may support early cardiometabolic risk identification and longitudinal health surveillance. CI - (c) 2026 The Author(s). Physiological Reports published by Wiley Periodicals LLC on behalf of The Physiological Society and the American Physiological Society. FAU - Gonzalez-Fimbres, Roberto A AU - Gonzalez-Fimbres RA AUID- ORCID: 0000-0003-2166-7085 AD - Licenciatura en Entrenamiento Deportivo, Unidad Academica Hermosillo, Universidad Estatal de Sonora, Hermosillo, Sonora, Mexico. FAU - Cuevas-Castro, Claudia S AU - Cuevas-Castro CS AD - Licenciatura en Entrenamiento Deportivo, Unidad Academica Hermosillo, Universidad Estatal de Sonora, Hermosillo, Sonora, Mexico. FAU - Ramirez-Siqueiros, Maria G AU - Ramirez-Siqueiros MG AD - Licenciatura en Entrenamiento Deportivo, Unidad Academica Hermosillo, Universidad Estatal de Sonora, Hermosillo, Sonora, Mexico. FAU - Valencia-Falcon, Teresita AU - Valencia-Falcon T AD - Licenciatura en Entrenamiento Deportivo, Unidad Academica Hermosillo, Universidad Estatal de Sonora, Hermosillo, Sonora, Mexico. FAU - Flatt, Andrew AU - Flatt A AD - Health Sciences and Kinesiology, Biodynamics and Human Performance Center, Georgia Southern University, Savannah, Georgia, USA. LA - eng GR - UES-PII-23-UAH-LED-01/Universidad Estatal de Sonora/ PT - Journal Article PL - United States TA - Physiol Rep JT - Physiological reports JID - 101607800 SB - IM MH - Humans MH - *Heart Rate/physiology MH - Male MH - Female MH - Adult MH - *Metabolic Syndrome/physiopathology MH - Middle Aged MH - Young Adult MH - Adolescent MH - *Rest/physiology PMC - PMC13334455 OTO - NOTNLM OT - RMSSD OT - autonomic function OT - exercise physiology OT - metabolic health OT - physiological monitoring OT - wearable technology COIS- The authors report no financial or personal relationships with other people or organizations that could inappropriately influence or bias their work. The authors report no conflict of interest. EDAT- 2026/07/06 13:29 MHDA- 2026/07/06 13:30 PMCR- 2026/07/06 CRDT- 2026/07/06 06:14 PHST- 2026/06/22 00:00 [revised] PHST- 2026/06/12 00:00 [received] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/07/06 13:30 [medline] PHST- 2026/07/06 13:29 [pubmed] PHST- 2026/07/06 06:14 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - PHY271008 [pii] AID - 10.14814/phy2.71008 [doi] PST - ppublish SO - Physiol Rep. 2026 Jul;14(13):e71008. doi: 10.14814/phy2.71008. PMID- 42404934 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Physical activity awareness and its relationship with motivation among college students: development and validation of a Multidimensional Scale. PG - 1856461 LID - 10.3389/fpubh.2026.1856461 [doi] LID - 1856461 AB - INTRODUCTION: Physical activity (PA) levels remain insufficient among young adults, particularly college students, whose behavioral patterns often persist into adulthood. Although psychological factors are recognized as important determinants of PA behavior, limited attention has been paid to how individuals perceive and interpret their own physical activity and surrounding context. This study aimed to develop and validate a multidimensional scale measuring college students' perceived PA awareness. METHODS: A sequential mixed-method design was employed. In the qualitative phase, focus group interviews were conducted to explore college students' understanding of PA awareness. Based on thematic analysis, four dimensions were identified: personal PA awareness, social support awareness, environmental awareness, and PA recommendation awareness. An initial item pool was then developed and administered to 994 undergraduate students from eight universities. Confirmatory factor analysis (CFA) was conducted to examine the factorial validity of the scale, and internal consistency reliability was assessed using Cronbach's alpha coefficients. RESULTS: CFA supported a stable four-factor structure with acceptable model fit indices (RMSEA = 0.046, SRMR = 0.035, CFI = 0.968). The subscales demonstrated satisfactory internal consistency, with Cronbach's ? values ranging from 0.741 to 0.919. These findings provide empirical support for the reliability and construct validity of the proposed scale. DISCUSSION: The findings suggest that PA awareness is a multidimensional psychological construct reflecting both individual perceptions and contextual influences. The developed scale may contribute to a better understanding of motivational processes underlying physical activity engagement among college students and provide a structured framework for future research on psychological determinants of PA behavior. CI - Copyright (c) 2026 Shangguan, Xie and Hamilton. FAU - Shangguan, Rulan AU - Shangguan R AD - School of Physical Education, South China University of Technology, Guangzhou, China. FAU - Xie, Jiajing AU - Xie J AD - School of Physical Education, South China University of Technology, Guangzhou, China. FAU - Hamilton, Xiaofen AU - Hamilton X AD - Department of Curriculum and Instruction, College of Education, The University of Texas at Austin, Austin, TX, United States. LA - eng PT - Journal Article PT - Validation Study DEP - 20260619 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Students/psychology/statistics & numerical data MH - Universities MH - Female MH - *Motivation MH - *Exercise/psychology MH - Young Adult MH - Reproducibility of Results MH - Male MH - Focus Groups MH - *Awareness MH - Psychometrics MH - Factor Analysis, Statistical MH - Surveys and Questionnaires/standards MH - Adolescent MH - Qualitative Research MH - Adult MH - *Health Knowledge, Attitudes, Practice PMC - PMC13328250 OTO - NOTNLM OT - college students OT - health behavior OT - mixed methods OT - physical activity awareness OT - psychometric validation OT - scale development COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/06 10:10 MHDA- 2026/07/06 12:41 PMCR- 2026/06/19 CRDT- 2026/07/06 05:40 PHST- 2026/04/15 00:00 [received] PHST- 2026/05/07 00:00 [revised] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/07/06 12:41 [medline] PHST- 2026/07/06 10:10 [pubmed] PHST- 2026/07/06 05:40 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1856461 [doi] PST - epublish SO - Front Public Health. 2026 Jun 19;14:1856461. doi: 10.3389/fpubh.2026.1856461. eCollection 2026. PMID- 42403893 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260706 LR - 20260813 IS - 1178-6965 (Print) IS - 1178-6965 (Electronic) IS - 1178-6965 (Linking) VI - 19 DP - 2026 TI - Skeletal Muscle Mass and Visceral Fat are Independently Associated with Poorly Controlled Asthma in Children with Obesity: A Cross-Sectional Study. PG - 600914 LID - 10.2147/JAA.S600914 [doi] LID - 600914 AB - PURPOSE: The role of body composition-particularly skeletal muscle mass and visceral fat-in asthma control among children with obesity remains unclear. We compared body composition between children with obesity with and without asthma and examined associations with asthma control. PATIENTS AND METHODS: We enrolled 191 children with obesity aged 6-14 years (85 with asthma, 106 without). Skeletal muscle mass (SMM)-to-body weight (WT) ratio and visceral fat area (VFA) were measured by multi-frequency bioelectrical impedance analysis. Poorly controlled asthma was defined using validated cut-points: Childhood Asthma Control Test /=12). Variables were screened by least absolute shrinkage and selection operator logistic regression; the model was assessed by receiver operating characteristic curve, calibration, and decision-curve analyses. RESULTS: The obese-asthma group had lower SMM/WT than the simple-obesity group (30.17% vs 31.51%, P<0.001); VFA did not differ significantly (P=0.051). Among children with obese-asthma, the poorly controlled group showed lower SMM/WT (P=0.002) and higher VFA (P=0.011). In multivariable analysis, SMM/WT (OR=0.664 per 1%, 95% CI 0.497-0.889, P=0.006), VFA (OR=1.014 per 1 cm(2), 95% CI 1.001-1.028, P=0.034), maximal mid-expiratory flow (MMEF) percent predicted (OR=1.073, 95% CI 1.007-1.143, P=0.029), and extracellular water to total body water ratio (ECW/TBW) (OR=1.719 per 0.01, 95% CI 1.000-2.956, P=0.050) were independently associated with poorly controlled asthma. The area under the curve (AUC) was 0.807 (95% CI 0.709-0.905; sensitivity 76.9%, specificity 75.8%; mean absolute error 0.027). CONCLUSION: Lower SMM/WT, higher VFA, higher MMEF percent predicted, and higher ECW/TBW were independently associated with poorly controlled asthma in children with obesity. The four-variable model showed good discrimination (AUC=0.807). These exploratory associations require prospective validation before clinical application. CI - (c) 2026 Wang et al. FAU - Wang, Zhiyuan AU - Wang Z AUID- ORCID: 0000-0001-7990-9740 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. FAU - Zhao, Junlin AU - Zhao J AUID- ORCID: 0009-0002-9080-9622 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. FAU - Wang, Yanan AU - Wang Y AUID- ORCID: 0009-0008-3176-160X AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. FAU - Dai, Qianqian AU - Dai Q AUID- ORCID: 0009-0005-7647-0812 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. FAU - Qu, Shengmeng AU - Qu S AUID- ORCID: 0009-0004-2746-3408 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. FAU - Ru, Liang AU - Ru L AUID- ORCID: 0009-0002-2200-3889 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, People's Republic of China. LA - eng PT - Journal Article DEP - 20260629 PL - New Zealand TA - J Asthma Allergy JT - Journal of asthma and allergy JID - 101543450 PMC - PMC13332121 OAB - WHY DID WE DO THIS STUDY? Obesity and asthma are both becoming more common in children. Children who have both conditions may have less well-controlled asthma. Doctors usually record only height and weight, which do not show how much muscle a child has or where body fat is stored. We wanted to learn whether measuring muscle and fat separately could help explain why some children with obesity have poorer asthma control. WHAT DID WE DO? We studied 191 children with obesity aged 6-14 years. We used a body-composition scanner to estimate muscle mass and visceral fat (the fat stored around internal organs). We compared children with and without asthma, and-among those with asthma-children whose symptoms were poorly controlled with the rest of the asthma group, who had comparatively better symptom control. WHAT DID WE FIND? Children with obesity and asthma had less muscle relative to their body weight than children with obesity alone. Among the children with asthma, those whose asthma was poorly controlled tended to have lower muscle mass and higher visceral fat. Using these measures, we built a preliminary tool to help estimate which children might be at higher risk of poor asthma control. WHAT DOES THIS MEAN? Looking at body composition, rather than weight alone, may give doctors additional information about asthma in children with obesity, and could support more individualized care in the future. Further studies in other groups of children are needed before these measures can be used in routine practice. OABL- eng OTO - NOTNLM OT - asthma OT - pediatric obesity OT - sarcopenic obesity OT - skeletal muscle mass OT - visceral fat COIS- The authors declare no competing interests in this work. EDAT- 2026/07/06 10:10 MHDA- 2026/07/06 10:11 PMCR- 2026/06/29 CRDT- 2026/07/06 05:28 PHST- 2026/02/03 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/07/06 10:11 [medline] PHST- 2026/07/06 10:10 [pubmed] PHST- 2026/07/06 05:28 [entrez] PHST- 2026/06/29 00:00 [pmc-release] AID - 600914 [pii] AID - 10.2147/JAA.S600914 [doi] PST - epublish SO - J Asthma Allergy. 2026 Jun 29;19:600914. doi: 10.2147/JAA.S600914. eCollection 2026. PMID- 42403888 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260706 LR - 20260813 IS - 1178-6965 (Print) IS - 1178-6965 (Electronic) IS - 1178-6965 (Linking) VI - 19 DP - 2026 TI - A Clinical Nomogram for Predicting Early Response to Biologics in Pediatric Allergic Asthma with Comorbid Allergic Rhinitis. PG - 604654 LID - 10.2147/JAA.S604654 [doi] LID - 604654 AB - BACKGROUND: The coexistence of allergic rhinitis (AR) and allergic asthma poses a significant burden on pediatric health. While biologics targeting type 2 inflammation have revolutionized treatment, individual responses vary significantly. There is a lack of practical tools to predict early therapeutic response before initiation. This study aimed to identify key baseline predictors and construct a nomogram to personalize the prediction of early response to biologics in children with AR and allergic asthma. METHODS: This retrospective cohort study included 246 children (recruited between January 2021 and August 2025) diagnosed with moderate-to-severe allergic AR and allergic asthma who received biologic therapy (Omalizumab or Dupilumab). Early response was assessed at 16 weeks based on a composite outcome involving the Asthma Control Test (ACT), visual analog scale (VAS) for nasal symptoms, and exacerbation history. Independent predictors were identified using LASSO regression and multivariate logistic regression analysis to build a nomogram. The model's performance was evaluated using the concordance index (C-index), calibration curves, and decision curve analysis (DCA). RESULTS: Of the 246 patients, 164 (66.7%) were classified as early responders. Multivariate analysis identified baseline fractional exhaled nitric oxide (FeNO), blood eosinophil count (EOS), total IgE levels, comorbidity of atopic dermatitis (AD), and Body Mass Index (BMI) as independent predictors. The developed nomogram demonstrated good discrimination with a C-index of 0.88 (95% CI: 0.83-0.93) in the training cohort and 0.85 (95% CI: 0.78-0.92) in the validation cohort. Calibration curves showed excellent agreement between predicted and observed probabilities. DCA indicated significant clinical net benefit across a wide range of threshold probabilities. CONCLUSION: We successfully developed a novel nomogram incorporating baseline type 2 inflammatory endotypes and AD comorbidity to predict early response to biologics in pediatric patients with allergic asthma and comorbid AR. This tool offers clinicians a practical method to screen potential "super-responders", thereby optimizing therapeutic decision-making and resource allocation. CI - (c) 2026 Wang et al. FAU - Wang, Lixin AU - Wang L AD - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. FAU - Kang, Zhaopeng AU - Kang Z AD - Health Management Center, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. FAU - Ma, Jun AU - Ma J AD - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. FAU - Wang, Chuanxi AU - Wang C AD - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. FAU - Jiang, Wanjin AU - Jiang W AD - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. FAU - Huang, Jingjiang AU - Huang J AD - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. FAU - Liu, Shaofeng AU - Liu S AD - Department of Otolaryngology Head and Neck Surgery, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, People's Republic of China. LA - eng PT - Journal Article DEP - 20260630 PL - New Zealand TA - J Asthma Allergy JT - Journal of asthma and allergy JID - 101543450 PMC - PMC13332785 OTO - NOTNLM OT - allergic asthma OT - allergic rhinitis OT - biological therapy OT - nomogram OT - pediatrics OT - type 2 inflammation COIS- Lixin Wang and Zhaopeng Kang are co-first authors for this study. The authors declare that they have no competing interests for this work. EDAT- 2026/07/06 10:10 MHDA- 2026/07/06 10:11 PMCR- 2026/06/30 CRDT- 2026/07/06 05:28 PHST- 2026/03/02 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/06 10:11 [medline] PHST- 2026/07/06 10:10 [pubmed] PHST- 2026/07/06 05:28 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - 604654 [pii] AID - 10.2147/JAA.S604654 [doi] PST - epublish SO - J Asthma Allergy. 2026 Jun 30;19:604654. doi: 10.2147/JAA.S604654. eCollection 2026. PMID- 42403552 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 1947-6108 (Electronic) IS - 1947-6094 (Print) IS - 1947-6108 (Linking) VI - 22 IP - 3 DP - 2026 TI - Primary Tricuspid Regurgitation in ACHD: Diagnosis and Treatment. PG - 88-97 LID - 10.14797/mdcvj.1813 [doi] AB - Primary tricuspid valve regurgitation includes congenital and acquired disorders, especially Ebstein anomaly and tricuspid valve dysplasia. Severe tricuspid regurgitation causes progressive right atrial and ventricular dilation, arrhythmias, exercise intolerance, impaired left ventricular filling, and eventual biventricular dysfunction. Some patients remain minimally symptomatic for decades despite progressive disease. Poor prognostic factors include severe cardiomegaly, ventricular dysfunction, cyanosis, and arrhythmias. Surgical indications include symptoms, declining exercise capacity, cyanosis, progressive right ventricular enlargement or dysfunction, recurrent arrhythmias, and, in selected asymptomatic patients, severe regurgitation with right ventricular dilation. The Cone repair procedure restores native valve competence, improves right and left ventricular interaction, promotes reverse remodeling, and has low operative risk in experienced centers. Current evidence supports individualized and earlier surgical repair, preferably during childhood and in specialized centers, to improve ventricular function, quality of life, and long-term survival. CI - Copyright: (c) 2026 The Author(s). FAU - Da Fonseca Da Silva, Luciana AU - Da Fonseca Da Silva L AUID- ORCID: 0000-0001-8070-3539 AD - Da Silva Center for Ebstein's Anomaly, UPMC Children's Hospital of Pittsburgh, Pennsylvania, USA. LA - eng PT - Journal Article PT - Review DEP - 20260630 PL - United States TA - Methodist Debakey Cardiovasc J JT - Methodist DeBakey cardiovascular journal JID - 101508600 SB - IM MH - Humans MH - *Tricuspid Valve Insufficiency/physiopathology/surgery/diagnostic imaging/etiology/mortality/diagnosis MH - *Tricuspid Valve/physiopathology/surgery/diagnostic imaging/abnormalities MH - Treatment Outcome MH - *Ebstein Anomaly/physiopathology/diagnostic imaging/surgery/complications/mortality MH - Risk Factors MH - Recovery of Function MH - Predictive Value of Tests MH - Ventricular Function, Right MH - *Cardiac Surgical Procedures/adverse effects MH - *Cardiac Catheterization/adverse effects MH - Hemodynamics PMC - PMC13330852 OTO - NOTNLM OT - Ebstein's anomaly OT - adult congenital heart disease OT - cone repair OT - percutaneous ASD closure OT - tricuspid valve insufficiency COIS- The author has no competing interests to declare. EDAT- 2026/07/06 06:31 MHDA- 2026/07/06 06:32 PMCR- 2026/06/30 CRDT- 2026/07/06 05:25 PHST- 2026/02/23 00:00 [received] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/07/06 06:32 [medline] PHST- 2026/07/06 06:31 [pubmed] PHST- 2026/07/06 05:25 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - 10.14797/mdcvj.1813 [doi] PST - epublish SO - Methodist Debakey Cardiovasc J. 2026 Jun 30;22(3):88-97. doi: 10.14797/mdcvj.1813. eCollection 2026. PMID- 42403118 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 1681-7168 (Electronic) IS - 1022-386X (Linking) VI - 36 IP - 7 DP - 2026 Jul TI - Stature Estimation from Foot Anthropometry in a Pakistani Cohort. PG - 841-845 LID - 10.29271/jcpsp.2026.07.841 [doi] AB - OBJECTIVE: To investigate the relationships between an individual's height and various foot dimensions and to assess the statistical differences between right and left foot measurements. STUDY DESIGN: A cross-sectional study. Place and Duration of the Study: Department of Forensic Medicine, Dow University of Health Sciences, Ojha Campus, Karachi, Pakistan, from August to October 2024. METHODOLOGY: Healthy individuals of either gender, aged 18 to 60 years, with no physical disability, and who could stand upright without assistance were invited to participate. Individuals with any visible spinal or foot deformity were excluded. Participants were assessed for stature and foot measurements. RESULTS: A total of 112 participants were included in this study. The mean height for both genders was 65.185 +/- 3.7482 inches; the mean left and right foot breadths were 4.566 +/- 2.8491 and 4.481 +/- 1.5324 inches, respectively; the mean left foot length (LFL) and right foot length (RFL) were 9.762 +/- 1.3573 and 9.591 +/- 1.5373 inches, respectively. Foot length (FL) in males (RFL: r = 0.129, LFL: r = 0.224) and females (RFL: r = 0.158, LFL: r = 0.519) had the strongest correlation of all the variables. Specifically, the LFL of females showed a significant correlation with their stature (p <0.001). CONCLUSION: This study corroborates the significant correlation between foot measurements and stature, particularly emphasising the reliability of FL as a predictor of height. KEY WORDS: Stature, Foot, Estimation, Foot anthropometry, Pakistan. FAU - Irshad, Raheela AU - Irshad R AD - Department of Forensic Medicine, Dow University of Health Sciences, Ojha Campus, Karachi, Pakistan. FAU - Baig, Ramsha Urooj AU - Baig RU AD - Department of Forensic Medicine, Dow University of Health Sciences, Ojha Campus, Karachi, Pakistan. FAU - Naz, Ramlah AU - Naz R AD - Department of Forensic Medicine, Dow University of Health Sciences, Ojha Campus, Karachi, Pakistan. FAU - Fatima, Mehreen AU - Fatima M AD - Department of Forensic Medicine, Dow University of Health Sciences, Ojha Campus, Karachi, Pakistan. LA - eng PT - Journal Article PL - Pakistan TA - J Coll Physicians Surg Pak JT - Journal of the College of Physicians and Surgeons--Pakistan : JCPSP JID - 9606447 SB - IM MH - Humans MH - Male MH - Female MH - *Foot/anatomy & histology MH - Pakistan MH - *Body Height MH - Adult MH - *Anthropometry/methods MH - Cross-Sectional Studies MH - Middle Aged MH - Adolescent MH - Young Adult EDAT- 2026/07/06 06:31 MHDA- 2026/07/06 06:32 CRDT- 2026/07/06 03:47 PHST- 2025/09/22 00:00 [received] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/07/06 06:32 [medline] PHST- 2026/07/06 06:31 [pubmed] PHST- 2026/07/06 03:47 [entrez] AID - 040579197 [pii] AID - 10.29271/jcpsp.2026.07.841 [doi] PST - ppublish SO - J Coll Physicians Surg Pak. 2026 Jul;36(7):841-845. doi: 10.29271/jcpsp.2026.07.841. PMID- 42402933 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260901 IS - 1526-3231 (Electronic) IS - 0749-8063 (Linking) VI - 42 IP - 9 DP - 2026 Sep TI - Lateral Femoral Condyle Angle Is an Anatomic Risk Factor for Anterior Cruciate Ligament Primary Injury and Secondary Graft Rerupture. PG - 1748-1760 LID - 10.1002/arj.70322 [doi] AB - PURPOSE: To define the lateral femoral condylar angle (LFCA)-a parameter measuring condylar inclination-and assess its predictive capacity for primary and recurrent anterior cruciate ligament (ACL) injuries. METHODS: Patients aged 18 to 50 years who underwent primary ACL reconstruction between 2017 and 2022 were screened. Those with graft rerupture were matched 1:1:1 by sex, age, body mass index, and meniscal status to ACL-intact controls and patients without graft failure during a minimum 48-month follow-up. LFCA was measured as the angle between the long axis of the distal femur and the axis of the lateral femoral condyle, alongside 38 established parameters using preoperative 3.0-T magnetic resonance imaging scans. Intergroup differences were assessed with one-way analysis of variance; multivariate regression and receiver operating characteristic analyses identified independent predictors and evaluated predictive performance. RESULTS: The study included 540 patients (180 per group: primary ACL injury, rerupture, controls). One-way analysis of variance revealed a significant gradient in LFCA across controls (81.3 degrees , 95% CI: 80.8-81.8 degrees ), primary injuries (81.9 degrees , 95% CI: 81.5-82.3 degrees ), and reruptures (84.2 degrees , 95% CI: 83.7-84.6 degrees ) (P < .001). In multivariate models adjusted for baseline factors, LFCA independently predicted primary injury (odds ratio [OR] = 1.27, 95% CI: 1.13-1.42, P < .001; area under the curve [AUC] = .576) and rerupture (OR = 1.46, 95% CI: 1.21-1.76, P < .001; AUC = .704). Combined models incorporating LFCA with tibial slopes, notch angle, and notch height achieved an AUC of .847 for primary injury prediction, whereas models with LFCA, lateral condylar flexion curvature radius, slope asymmetry, and tibial AP distance reached an AUC of .817 for rerupture. LFCA alone with lateral condylar flexion curvature radius yielded an AUC of .777 for rerupture prediction. Sex-stratified analyses confirmed LFCA predicted rerupture in both male patients (OR = 1.44, 95% CI: 1.19-1.75) and female patients (OR = 1.49, 95% CI: 1.16-1.92), and primary injury in male patients (OR = 1.30, 95% CI: 1.15-1.48). CONCLUSIONS: LFCA is an independent predictor of ACL injury, showing particular strength in identifying Asian patients at high risk for graft rerupture. LEVEL OF EVIDENCE: Level III, retrospective case-control study. CI - (c) 2026 the Arthroscopy Association of North America. FAU - Wang, Ding-Yu AU - Wang DY AD - Department of Sports Medicine, Peking University Third Hospital, Beijing, China. AD - Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing, China. AD - Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China. FAU - Liu, Jia-Xin AU - Liu JX AUID- ORCID: 0009-0009-6600-7970 AD - Department of Sports Medicine, Peking University Third Hospital, Beijing, China. AD - Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing, China. AD - Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China. FAU - Du, Xin-Wei AU - Du XW AD - Department of Sports Medicine, Peking University Third Hospital, Beijing, China. AD - Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing, China. AD - Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China. FAU - Wang, Ling-Xiao AU - Wang LX AD - Department of Sports Medicine, Peking University Third Hospital, Beijing, China. AD - Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing, China. AD - Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China. FAU - Zhang, Song-Lin AU - Zhang SL AD - Department of Sports Medicine, Peking University Third Hospital, Beijing, China. AD - Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing, China. AD - Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China. FAU - Jiang, Dong AU - Jiang D AUID- ORCID: 0000-0003-4380-7683 AD - Department of Sports Medicine, Peking University Third Hospital, Beijing, China. AD - Institute of Sports Medicine of Peking University, Beijing Key Laboratory of Sports Injuries, Beijing, China. AD - Engineering Research Center of Sports Trauma Treatment Technology and Devices, Ministry of Education, Beijing, China. LA - eng GR - L242104/Beijing Natural Science Foundation/ GR - 82441025/National Natural Science Foundation of China/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260705 PL - United States TA - Arthroscopy JT - Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association JID - 8506498 SB - IM MH - Humans MH - *Anterior Cruciate Ligament Injuries/surgery/diagnostic imaging MH - Male MH - Adult MH - Female MH - Risk Factors MH - Recurrence MH - *Femur/diagnostic imaging/anatomy & histology MH - *Anterior Cruciate Ligament Reconstruction/methods MH - Middle Aged MH - Young Adult MH - Magnetic Resonance Imaging MH - Adolescent MH - Retrospective Studies EDAT- 2026/07/06 06:32 MHDA- 2026/08/25 17:35 CRDT- 2026/07/06 02:33 PHST- 2025/06/10 00:00 [received] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/08/25 17:35 [medline] PHST- 2026/07/06 06:32 [pubmed] PHST- 2026/07/06 02:33 [entrez] AID - 10.1002/arj.70322 [doi] PST - ppublish SO - Arthroscopy. 2026 Sep;42(9):1748-1760. doi: 10.1002/arj.70322. Epub 2026 Jul 5. PMID- 42402486 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261014 IS - 1437-1596 (Electronic) IS - 0937-9827 (Linking) VI - 140 IP - 6 DP - 2026 Nov TI - Dental age assessment: orthopantomogram-based comparison of traditional methods and artificial intelligence in the adult population. PG - 4167-4179 LID - 10.1007/s00414-026-03908-9 [doi] AB - Dental age estimation in adults represents an important component of forensic odontology and medicolegal practice. Recent artificial intelligence (AI) approaches have demonstrated improved performance compared to traditional morphometric techniques. This study aimed to compare the reliability and accuracy of three conventional dental age estimation methods with an AI-based approach. A total of 1000 digital orthopantomograms of adults aged 18-79 years with known chronological age were retrieved from the Department of Dental Anthropology database at the University of Zagreb School of Dental Medicine. Dental age was assessed using Kvaal's, Drusini's, and Cameriere's methods in ImageJ, and compared with an AI-based convolutional neural network model developed at the University of Zagreb Faculty of Electrical Engineering and Computing. Intraclass correlation coefficient (ICC) analysis and Bland-Altman plots demonstrated excellent reliability of the AI-based method (ICC = 0.965), with a mean bias of + 4.31 years and superior precision (CV = 4.34%, SEP = 3.64 years). In contrast, traditional methods showed poor reliability: Cameriere (ICC = 0.376; bias of + 9.16 years), Drusini (ICC = 0.331; bias of + 2.21 years), and Kvaal (ICC = 0.310; bias of + 15.7 years). Applicability rates were highest for the AI-based method (91.1%), followed by Cameriere (70.8%), Kvaal (63.1%), and Drusini (39.5%). Although the AI model demonstrated a systematic tendency toward age overestimation, it outperformed conventional methods and shows strong potential for application in forensic dental practice. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Tomljenovic, Filipa AU - Tomljenovic F AUID- ORCID: 0009-0008-6629-3244 AD - Department of Dental Anthropology, University of Zagreb School of Dental Medicine, Zagreb, Croatia. fspehar@sfzg.hr. FAU - Vodanovic, Marin AU - Vodanovic M AUID- ORCID: 0000-0002-1935-8657 AD - Department of Dental Anthropology, University of Zagreb School of Dental Medicine, Zagreb, Croatia. AD - University Hospital Centre Zagreb, Zagreb, Croatia. FAU - Sribar, Andrej AU - Sribar A AUID- ORCID: 0000-0002-6517-9895 AD - Department of Dental Anthropology, University of Zagreb School of Dental Medicine, Zagreb, Croatia. AD - Dubrava University Hospital, Zagreb, Croatia. FAU - Brkic, Hrvoje AU - Brkic H AUID- ORCID: 0000-0003-4284-7739 AD - Department of Dental Anthropology, University of Zagreb School of Dental Medicine, Zagreb, Croatia. AD - University Hospital Centre Zagreb, Zagreb, Croatia. AD - University of Lisbon Faculty of Dental Medicine, Lisbon, Portugal. FAU - Milosevic, Denis AU - Milosevic D AUID- ORCID: 0000-0002-4214-178X AD - Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, Croatia. FAU - Subasic, Marko AU - Subasic M AUID- ORCID: 0000-0002-4321-4557 AD - Faculty of Electrical Engineering and Computing, University of Zagreb, Zagreb, Croatia. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260706 PL - Germany TA - Int J Legal Med JT - International journal of legal medicine JID - 9101456 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Adult MH - *Radiography, Panoramic MH - Middle Aged MH - Adolescent MH - Aged MH - *Artificial Intelligence MH - Young Adult MH - Reproducibility of Results MH - Female MH - Male MH - Convolutional Neural Networks MH - Image Processing, Computer-Assisted OTO - NOTNLM OT - Artificial intelligence OT - Convolutional neural network OT - Deep learning OT - Dental age estimation OT - Forensic odontology OT - Panoramic radiography COIS- Declarations. Ethics approval: The study protocol was reviewed and approved by the Ethics Committee of the School of Dental Medicine, University of Zagreb (approval no. 05-PA-12-3/2024; December 10, 2024). The study was conducted in accordance with institutional guidelines and the Declaration of Helsinki. Informed consent: This study used retrospectively collected, fully anonymised radiographic data obtained during routine clinical practice. The Ethics Committee waived the requirement for informed consent due to the study's retrospective nature and the use of anonymised data. The study complied with the Declaration of Helsinki. Clinical trial number: not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/06 00:30 MHDA- 2026/10/12 17:30 CRDT- 2026/07/05 23:02 PHST- 2026/04/03 00:00 [received] PHST- 2026/06/28 00:00 [accepted] PHST- 2026/10/12 17:30 [medline] PHST- 2026/07/06 00:30 [pubmed] PHST- 2026/07/05 23:02 [entrez] AID - 10.1007/s00414-026-03908-9 [pii] AID - 10.1007/s00414-026-03908-9 [doi] PST - ppublish SO - Int J Legal Med. 2026 Nov;140(6):4167-4179. doi: 10.1007/s00414-026-03908-9. Epub 2026 Jul 6. PMID- 42402421 OWN - NLM STAT- MEDLINE DCOM- 20260705 LR - 20260813 IS - 1365-2214 (Electronic) IS - 0305-1862 (Print) IS - 0305-1862 (Linking) VI - 52 IP - 4 DP - 2026 Jul TI - Translation and Cross-Cultural Adaptation of the Family Nutrition and Physical Activity Screening Tool for Portuguese Well-Child Visits. PG - e70316 LID - 10.1111/cch.70316 [doi] LID - e70316 AB - BACKGROUND: Family environments play a critical role in shaping children's lifestyle behaviours that influence obesity risk. However, culturally validated instruments to assess these behaviours are lacking in Portuguese primary care. AIM: This study aims to translate and culturally adapt the Family Nutrition and Physical Activity (FNPA) screening tool for use in Portugal (FNPA-PT) and to evaluate its face and content validity through cognitive interviews with parents attending well-child visits. DESIGN AND METHODS: An exploratory, descriptive study followed internationally endorsed guidelines (Beaton; MAPI) for translation and cross-cultural adaptation. The process comprised seven stages: forward translations, synthesis, back translations, comparisons of back translations, expert committee review, cognitive debriefing and final proofreading. Ten parents of five-year-old children attending a public primary care centre in Lisbon completed the FNPA-PT while participating in individual cognitive interviews. Data were analysed using Content Analysis, guided by Tourangeau's four-stage response model. RESULTS: Semantic equivalence between forward and back translations was high (85% of items with satisfactory or perfect equivalence). Minor linguistic and cultural adaptations were introduced to improve clarity and contextual relevance. Cognitive interviews indicated that the FNPA-PT was well understood, acceptable to parents, and feasible to complete during well-child visits. Parents valued the questionnaire's comprehensiveness and its potential to enhance awareness and stimulate discussion about family health behaviours. Minor revisions addressed comprehension issues in three items related to milk consumption, screen time and sleep. CONCLUSIONS: The FNPA-PT demonstrated strong face and content validity and high acceptability among Portuguese parents. It provides a culturally appropriate, family-centred tool for health professionals to support early identification of obesogenic environments and to guide preventive counselling in primary care. The study also offers a transparent methodological pathway for translating and adapting behavioural measures across languages and settings. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Rodrigues, Sonia Borges AU - Rodrigues SB AUID- ORCID: 0000-0002-9453-4876 AD - Nursing Research, Innovation and Development Centre of Lisbon (CIDNUR), School of Nursing, Universidade de Lisboa, Lisbon, Portugal. AD - Department of Child and Adolescent Nursing, School of Nursing, Universidade de Lisboa, Lisbon, Portugal. FAU - Rodrigues, Ricardo Borges AU - Rodrigues RB AUID- ORCID: 0000-0002-6720-2905 AD - Department of Psychology, Instituto Universitario de Lisboa (Iscte-IUL), Lisbon, Portugal. AD - Centro de Investigacao e Intervencao Social (CIS-Iscte), Lisbon, Portugal. FAU - Saboga-Nunes, Luis AU - Saboga-Nunes L AD - Department of Public Health, Institute of Sociology, University of Education Freiburg, Freiburg, Germany. AD - UNESCO Chair and WHO Collaborating Center in Global Health & Education, Paris, France. FAU - Barros, Luisa AU - Barros L AD - Faculty of Psychology, University of Lisbon, Lisbon, Portugal. AD - CICPsi, Center for Research in Psychological Science, University of Lisbon, Lisbon, Portugal. FAU - Salantera, Sanna AU - Salantera S AUID- ORCID: 0000-0003-2529-6699 AD - Department of Nursing Science, Faculty of Medicine, University of Turku, Turku, Finland. AD - Turku University Hospital, Turku, Finland. LA - eng PT - Journal Article PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM MH - Humans MH - Portugal/epidemiology MH - Child, Preschool MH - Male MH - Female MH - Translations MH - Cross-Cultural Comparison MH - Surveys and Questionnaires MH - Reproducibility of Results MH - *Exercise MH - Primary Health Care MH - Parents/psychology MH - *Pediatric Obesity/prevention & control PMC - PMC13382483 OTO - NOTNLM OT - cognitive interviews OT - cultural adaptation OT - family nutrition and physical activity (FNPA) OT - paediatric obesity OT - patient-reported outcome measures OT - primary health care OT - well-child visits COIS- The authors declare no conflicts of interest. EDAT- 2026/07/06 04:10 MHDA- 2026/07/06 04:11 PMCR- 2026/07/20 CRDT- 2026/07/05 21:42 PHST- 2026/05/29 00:00 [revised] PHST- 2025/11/07 00:00 [received] PHST- 2026/06/13 00:00 [accepted] PHST- 2026/07/06 04:11 [medline] PHST- 2026/07/06 04:10 [pubmed] PHST- 2026/07/05 21:42 [entrez] PHST- 2026/07/20 00:00 [pmc-release] AID - CCH70316 [pii] AID - 10.1111/cch.70316 [doi] PST - ppublish SO - Child Care Health Dev. 2026 Jul;52(4):e70316. doi: 10.1111/cch.70316. PMID- 42401849 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260929 IS - 1471-2377 (Electronic) IS - 1471-2377 (Linking) VI - 26 IP - 1 DP - 2026 Jul 4 TI - Screen time patterns and cognitive screening outcomes (MoCA-Ina) in adolescents: a cross-sectional study. LID - 10.1186/s12883-026-05128-5 [doi] LID - 609 AB - BACKGROUND: Adolescent screen exposure is increasing, yet clinically interpretable thresholds for cognitive risk are unclear. This study examined associations between daily screen time and cognitive screening performance and derived a screen-time cutoff associated with cognitive impairment. METHODS: We conducted an observational cross-sectional study (March-April 2022) at a private junior high school in Indonesia during online learning. Students completed digital questionnaires reporting educational and recreational screen time and a directly reported overall estimate; a computed overall (educational + recreational) was generated to assess reporting consistency. Cognitive function was assessed using the MoCA-Ina, with < 24 as the primary impairment threshold based on recent psychometric evidence favoring lower cutoffs for improved classification accuracy. RESULTS: Sixty-seven adolescents were included (34 girls, 50.7%; 33 boys, 49.3%), with median age 13.0 years (12.0-16.0) and median MoCA-Ina 25.0 (19.0-31.0). MoCA-Ina did not differ by sex (girls 25.0 [19.0-31.0] vs. boys 26.0 [20.0-30.0]; p = 0.244). Recreational screen time correlated inversely with MoCA-Ina (rho = -0.446, p < 0.001), as did overall screen time (rho = -0.360, p = 0.003), whereas educational screen time was not associated (rho = -0.061, p = 0.624). In adjusted regression, overall screen time remained negatively associated with MoCA-Ina (beta = -0.24 per hour/day; 95% CI - 0.41 to - 0.07; p = 0.007), while age was positively associated (beta = 0.96; 95% CI 0.07 to 1.85; p = 0.034). All variance inflation factors were below 2.5, indicating no substantial multicollinearity. ROC analysis showed fair discrimination (AUC 0.66; optimism-corrected AUC after bootstrap internal validation [1,000 resamples]: 0.63) with an optimal cutoff > 8.97 h/day (sensitivity 83.3%, specificity 48.8%, PPV 47.6%, NPV 84.0%); risk of impairment was higher above the cutoff (RR 2.98; 95% CI 1.15-7.72; p = 0.010; OR 4.77; 95% CI 1.40-16.31). CONCLUSIONS: High daily screen exposure was associated with poorer cognitive screening performance. The > 8.97-hour/day threshold represents a preliminary, hypothesis-generating cutoff that may help identify adolescents at elevated likelihood of cognitive impairment, pending external validation in larger, more diverse samples. TRIAL REGISTRATION: 071/K-LKJ/ETIK/II/2022. CI - (c) 2026. The Author(s). FAU - Gunawan, Pricilla Yani AU - Gunawan PY AUID- ORCID: 0000-0002-5620-3267 AD - Department of Neurology, Faculty of Medicine, Universitas Pelita Harapan, Jl. Jenderal Sudirman No.15, Tangerang, Banten, 15810, Indonesia. pricilla.yani@outlook.com. AD - Department of Neurology, Siloam Hospitals Lippo Village, Tangerang, Indonesia. pricilla.yani@outlook.com. FAU - Andraina, Andraina AU - Andraina A AD - Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Banten, Indonesia. FAU - Wijaya, Jeremiah Hilkiah AU - Wijaya JH AD - School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia. FAU - Arjuna, Yang Yang Endro AU - Arjuna YYE AUID- ORCID: 0000-0002-5916-1453 AD - Department of Neurology, Siloam Hospitals Lippo Village, Tangerang, Indonesia. AD - Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Banten, Indonesia. FAU - Gunawan, Patricia Yulita AU - Gunawan PY AUID- ORCID: 0000-0002-3287-0671 AD - Department of Paediatrics, Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Banten, Indonesia. AD - Department of Paediatrics, University of Oxford, Oxford, UK. LA - eng PT - Journal Article PT - Observational Study DEP - 20260704 PL - England TA - BMC Neurol JT - BMC neurology JID - 100968555 SB - IM MH - Humans MH - Male MH - Cross-Sectional Studies MH - *Screen Time MH - Adolescent MH - Female MH - Child MH - *Cognitive Dysfunction/diagnosis/psychology MH - *Cognition MH - Media Exposure MH - Surveys and Questionnaires MH - Neuropsychological Tests MH - Indonesia PMC - PMC13613649 OTO - NOTNLM OT - Adolescent OT - Cognition OT - ROC curve OT - Screen time COIS- Declarations. Ethics approval and consent to participate: This observational cross-sectional study was reviewed and approved by the institutional ethics committee of the Faculty of Medicine, Pelita Harapan University (Approval No.: 071/K-LKJ/ETIK/II/2022). The study was conducted in accordance with the Declaration of Helsinki and applicable local regulations. Written informed consent to participate was obtained from all participants. For any participant under the age of 16 years, written informed consent was obtained from their parent or legal guardian prior to participation. Informed consent was obtained from all individual participants included in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/05 00:37 MHDA- 2026/09/25 05:31 PMCR- 2026/07/04 CRDT- 2026/07/04 23:34 PHST- 2026/02/10 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/09/25 05:31 [medline] PHST- 2026/07/05 00:37 [pubmed] PHST- 2026/07/04 23:34 [entrez] PHST- 2026/07/04 00:00 [pmc-release] AID - 10.1186/s12883-026-05128-5 [pii] AID - 5128 [pii] AID - 10.1186/s12883-026-05128-5 [doi] PST - epublish SO - BMC Neurol. 2026 Jul 4;26(1):609. doi: 10.1186/s12883-026-05128-5. PMID- 42401398 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260807 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 226 DP - 2026 Nov 1 TI - Gratitude for food as a driver of improved dietary behaviors: A scoping review. PG - 108703 LID - S0195-6663(26)00265-5 [pii] LID - 10.1016/j.appet.2026.108703 [doi] AB - Gratitude for food (GF) is a positive emotional response linked to healthier dietary behaviors, mindful eating, and food waste reduction. Despite increasing research interest internationally and in Japan, existing research has not been systematically integrated, and measurement tools remain fragmented. This study aims to systematically map and synthesize international and Japanese studies on GF, clarify current knowledge, detail the characteristics and thematic focuses of existing research, critically examine the variety and validation status of GF measurement tools, and identify the cultural and methodological gaps within the literature. A scoping review following PRISMA-ScR guidelines was conducted. Searches of five databases-SCOPUS, PubMed, EBSCO host, Ichushi-web, and J-stage-in English and Japanese were conducted covering publications from 1995 to 2025. Data extraction included study characteristics, GF measurement tools, and intervention details. Quantitative text mining analyzed the research themes. Thirty-nine studies were included, encompassing cross-sectional, intervention, qualitative, mixed-methods, and scale development designs. Five research focus clusters emerged: school lunches, nutrition education programs, food waste, mindful eating, and scale development. Five validated GF scales were identified, some with cross-cultural adaptations, but their use and validation were fragmented. Intervention studies were predominantly non-randomized controlled trials in Japan, focusing on school-aged children, with mixed evidence on effectiveness. GF is a culturally nuanced construct with important implications for promoting healthier dietary habits, reducing food waste, and fostering mindful eating. Future research should focus on harmonizing measurement tools and conducting rigorous intervention studies to advance the field. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Kawasaki, Yui AU - Kawasaki Y AD - Institute for SDGs Promotion, Organization for Social Implementation of Sustainability, Ochanomizu University, 2-1-1 Otsuka Bunkyo-ku, Tokyo, 112-8610, Japan. Electronic address: kawasaki.yui@ocha.ac.jp. FAU - Nagao-Sato, Sayaka AU - Nagao-Sato S AD - Graduate School of Public Health, Shizuoka Graduate University of Public Health, 4-27-2, Kita Ando, Aoi-ku, Shizuoka, 420-0881, Japan. Electronic address: sysato@s-sph.ac.jp. FAU - Yoshii, Emi AU - Yoshii E AD - Department of Food and Health Sciences, Faculty of Health and Human Development, The University of Nagano, Japan. Electronic address: yoshii.emi@u-nagano.ac.jp. FAU - Akamatsu, Rie AU - Akamatsu R AD - Natural Science Division, Faculty of Core Research, Ochanomizu University, 2-1-1 Otsuka Bunkyo-ku, Tokyo, 112-8610, Japan. Electronic address: akamatsu.rie@ocha.ac.jp. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260704 PL - England TA - Appetite JT - Appetite JID - 8006808 RN - 0 (Food Loss and Waste) SB - IM MH - Humans MH - *Feeding Behavior/psychology MH - *Diet, Healthy/psychology MH - Japan MH - Food Loss and Waste MH - Child MH - Mindfulness MH - *Food MH - Emotions MH - Health Behavior OTO - NOTNLM OT - Dietary behavior OT - Food waste OT - Gratitude OT - Mindful eating OT - Nutrition education COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Yui Kawasaki reports financial support was provided by the Moritani Scholarship Foundation [no grant number]. EDAT- 2026/07/05 00:37 MHDA- 2026/08/08 00:40 CRDT- 2026/07/04 19:34 PHST- 2026/03/01 00:00 [received] PHST- 2026/06/29 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/08/08 00:40 [medline] PHST- 2026/07/05 00:37 [pubmed] PHST- 2026/07/04 19:34 [entrez] AID - S0195-6663(26)00265-5 [pii] AID - 10.1016/j.appet.2026.108703 [doi] PST - ppublish SO - Appetite. 2026 Nov 1;226:108703. doi: 10.1016/j.appet.2026.108703. Epub 2026 Jul 4. PMID- 42400688 OWN - NLM STAT- MEDLINE DCOM- 20260704 LR - 20260813 IS - 1573-7322 (Electronic) IS - 1382-4147 (Print) IS - 1382-4147 (Linking) VI - 31 IP - 1 DP - 2026 Jul 4 TI - Mavacamten in adolescent obstructive hypertrophic cardiomyopathy: SCOUTing a way forward. LID - 10.1007/s10741-026-10655-x [doi] LID - 78 AB - Paediatric obstructive hypertrophic cardiomyopathy (oHCM) is a rare inherited cardiac disease that may present from childhood through adolescence and is associated with substantial long-term morbidity and mortality. Its management is based largely on observational studies and clinical experience and currently focusses on symptom improvement through medical therapy and, when indicated, septal reduction therapy to alleviate left ventricular outflow tract (LVOT) obstruction. In adult oHCM, mavacamten has established cardiac myosin inhibition as an effective strategy to reduce LVOT obstruction, but paediatric trial evidence has been lacking. The SCOUT-HCM trial is the first randomised placebo-controlled trial in adolescents to investigate the efficacy and safety of mavacamten for symptomatic oHCM. Among 44 adolescents (mean age 14.7 +/- 1.7 years) mavacamten significantly reduced Valsalva-provoked LVOT gradients at 28 weeks, confirming short-term physiological efficacy. Secondary and exploratory findings, including NYHA functional class, cardiac structure and biomarkers, showed a trend to improvement, without a signal of left ventricular systolic dysfunction. The positive results of SCOUT-HCM, align with larger and longer adult oHCM trials and are likely to influence clinical practice, supporting a cautious integration of mavacamten in adolescent oHCM management. Longer follow-up and broader paediatric studies should determine durability of benefit, validated patient-reported outcomes, exercise capacity, arrhythmia burden, long-term safety and the need for septal reduction therapy in paediatric oHCM. CI - (c) 2026. The Author(s). FAU - Bennetts, Joshua D AU - Bennetts JD AD - College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. FAU - Ngo, Doan T M AU - Ngo DTM AD - College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. FAU - Cheema, Baljash AU - Cheema B AD - Division of Cardiology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. FAU - Hosseini, Kaveh AU - Hosseini K AD - Department of Cardiology, Copenhagen University Hospital - Herlev and Gentofte, Copenhagen, Denmark. AD - Center for Translational Cardiology and Pragmatic Randomized Trials, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Verheyen, Nicolas AU - Verheyen N AD - Division of Cardiology, Department of Internal Medicine, University Heart Center, Medical University of Graz, Graz, Austria. FAU - Santner, Viktoria AU - Santner V AD - Division of Cardiology, Department of Internal Medicine, University Heart Center, Medical University of Graz, Graz, Austria. FAU - Tomasoni, Daniela AU - Tomasoni D AD - Cardiology, ASST Spedali Civili di Brescia and Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy. FAU - Sverdlov, Aaron L AU - Sverdlov AL AD - College of Health, Medicine and Wellbeing, University of Newcastle, Newcastle, NSW, Australia. aaron.sverdlov@newcastle.edu.au. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. aaron.sverdlov@newcastle.edu.au. AD - Cardiovascular Department, John Hunter Hospital, Newcastle, NSW, Australia. aaron.sverdlov@newcastle.edu.au. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20260704 PL - United States TA - Heart Fail Rev JT - Heart failure reviews JID - 9612481 RN - 0 (MYK-461) RN - 0 (Benzylamines) RN - 56HH86ZVCT (Uracil) SB - IM MH - Humans MH - Adolescent MH - *Cardiomyopathy, Hypertrophic/drug therapy/physiopathology MH - *Ventricular Outflow Obstruction, Left/drug therapy/physiopathology MH - Treatment Outcome MH - Benzylamines MH - Uracil/analogs & derivatives PMC - PMC13332878 OTO - NOTNLM OT - Adolescents OT - Hypertrophic obstructive cardiomyopathy OT - Mavacamten OT - SCOUT-HCM COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/07/05 00:03 MHDA- 2026/07/05 00:04 PMCR- 2026/07/04 CRDT- 2026/07/04 11:04 PHST- 2026/05/23 00:00 [received] PHST- 2026/06/28 00:00 [accepted] PHST- 2026/06/23 00:00 [revised] PHST- 2026/07/05 00:04 [medline] PHST- 2026/07/05 00:03 [pubmed] PHST- 2026/07/04 11:04 [entrez] PHST- 2026/07/04 00:00 [pmc-release] AID - 10.1007/s10741-026-10655-x [pii] AID - 10655 [pii] AID - 10.1007/s10741-026-10655-x [doi] PST - epublish SO - Heart Fail Rev. 2026 Jul 4;31(1):78. doi: 10.1007/s10741-026-10655-x. PMID- 42400239 OWN - NLM STAT- MEDLINE DCOM- 20260704 LR - 20260817 IS - 1369-7625 (Electronic) IS - 1369-6513 (Print) IS - 1369-6513 (Linking) VI - 29 IP - 4 DP - 2026 Aug TI - Exploring the Acceptability of Integrating Dietitians Into Primary Care Dental Services for Children. PG - e70753 LID - 10.1111/hex.70753 [doi] LID - e70753 AB - BACKGROUND: Dental caries is a common childhood non-communicable disease strongly associated with high sugar intake. Beyond oral health, a poor diet can affect children's growth, development, and overall well-being. While dietary advice is central to preventive dental care, some primary care dental clinics have introduced body mass index (BMI) assessments and further dietary advice to address wider nutritional concerns in children. However, these efforts are often constrained by limited nutrition training, time constraints and concerns about sensitivity. Integrating dietitians into primary dental care may help overcome these barriers by enhancing dietary guidance, supporting broader nutritional needs and facilitating structured BMI assessments with appropriate follow-up. AIM: To explore the acceptability of integrating dietitians into primary dental care for children, guided by the theoretical framework of acceptability (TFA). METHODS: Dental professionals and caregivers were recruited from South West England, and dietitians from across the United Kingdom (April-December 2024). Semi-structured interviews were analysed inductively using reflexive thematic analysis. Findings were interpreted through the TFA to examine how emotional, ethical and structural factors shaped perceptions of acceptability. RESULTS: Semi-structured interviews were conducted with 23 participants: 10 dental professionals, 6 dietitians and 7 caregivers. Four inductive themes captured participants reasoning: (1) Balancing enthusiasm and sensitivity; (2) Negotiating the realities of integration; (3) Clarifying boundaries and expertise and (4) Building collective confidence. These themes aligned closely with the TFA, showing how emotional, ethical and structural factors interacted. Acceptability emerged as a dynamic balance of emotional and ethical alignment, practical feasibility, conceptual clarity and shared confidence. Perceived effectiveness was a unifying thread, with integration seen as acceptable when safeguards ensured emotional safety, ethical grounding and organisational support. CONCLUSION: Integrating dietitians was viewed as widely acceptable when collaboratively, sensitively and structurally delivered and supported. CI - (c) 2026 The Author(s). Health Expectations published by John Wiley & Sons Ltd. FAU - Hallewell, Lauren AU - Hallewell L AUID- ORCID: 0009-0004-6039-1274 AD - School of Health Professions, Faculty of Health, University of Plymouth, Plymouth, UK. FAU - Bescos, Raul AU - Bescos R AUID- ORCID: 0000-0002-3939-4743 AD - School of Health Professions, Faculty of Health, University of Plymouth, Plymouth, UK. FAU - Brookes, Zoe AU - Brookes Z AUID- ORCID: 0000-0002-8096-6256 AD - Peninsula Dental School, Faculty of Health, University of Plymouth, Plymouth, UK. FAU - Parkin, Tracey AU - Parkin T AUID- ORCID: 0000-0002-7081-2253 AD - School of Health Professions, Faculty of Health, University of Plymouth, Plymouth, UK. FAU - Witton, Robert AU - Witton R AUID- ORCID: 0000-0002-6424-4376 AD - Peninsula Dental School, Faculty of Health, University of Plymouth, Plymouth, UK. FAU - Casas-Agustench, Patricia AU - Casas-Agustench P AUID- ORCID: 0000-0003-4424-1087 AD - School of Health Professions, Faculty of Health, University of Plymouth, Plymouth, UK. LA - eng PT - Journal Article PL - England TA - Health Expect JT - Health expectations : an international journal of public participation in health care and health policy JID - 9815926 SB - IM MH - Humans MH - *Nutritionists/psychology MH - *Primary Health Care/organization & administration MH - Child MH - Female MH - *Dental Care for Children/organization & administration MH - Male MH - Interviews as Topic MH - United Kingdom MH - Attitude of Health Personnel MH - Caregivers/psychology MH - Adult MH - England MH - Dentists/psychology PMC - PMC13332333 OTO - NOTNLM OT - children OT - dentistry OT - dietitian OT - interprofessional OT - nutrition COIS- The authors declare no conflicts of interest. Relevant professional affiliations include the British Dietetic Association, British Dental Association, College of Dietitians-Nutritionists of Catalonia and Member of the Association for Nutritionists. EDAT- 2026/07/04 16:11 MHDA- 2026/07/04 16:12 PMCR- 2026/07/03 CRDT- 2026/07/04 02:23 PHST- 2026/05/14 00:00 [revised] PHST- 2025/11/12 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/04 16:12 [medline] PHST- 2026/07/04 16:11 [pubmed] PHST- 2026/07/04 02:23 [entrez] PHST- 2026/07/03 00:00 [pmc-release] AID - HEX70753 [pii] AID - 10.1111/hex.70753 [doi] PST - ppublish SO - Health Expect. 2026 Aug;29(4):e70753. doi: 10.1111/hex.70753. PMID- 42399850 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jul 3 TI - Formative research on a post-discharge monitoring program using SQ-LNS to reduce acute malnutrition relapse risk in Mali : a qualitative study. LID - 10.1186/s12889-026-28378-x [doi] LID - 2296 AB - INTRODUCTION: Up to 75% of children treated for severe acute malnutrition (SAM) relapse within six months of recovery, yet evidence on post-discharge interventions remains limited. We conducted a formative assessment to understand how small-quantity lipid-based nutrient supplements (SQ-LNS) could be integrated in post-discharge care to prevent relapse. OBJECTIVE: This study aimed to inform whether and how a program integrating SQ-LNS into post-discharge monitoring could be implemented in Mali. Specifically, we aimed to: 1) identify barriers and enablers to post-discharge monitoring, 2) develop one or more post-discharge models based on recommendations, 3) understand the feasibility of these model(s), 4) describe acceptability of the model(s) and product, and 5) propose a final model to be piloted at larger scale. METHODS: This formative study comprised two iterative phases conducted between September 2024 and May 2025. In exploratory Phase One, we conducted semi-structured interviews with 12 caregivers of children with SAM and eight treatment providers, in triangulation with 13 focus groups among caregivers, health care workers (HCW's), and supervisors. Themes included current practices, anticipated challenges, and service delivery preferences. Findings informed a confirmatory Phase Two involving four direct observations of three delivery models implemented at four sites and 13 interviews with similar participants. Textual data were coded and thematically analyzed using Dedoose software. RESULTS: Although national guidelines recommend routine post-discharge monitoring for SAM children, it was rarely practiced due to limited awareness among HCW's. Both caregivers and HCW's supported the idea of post-SAM monitoring, preferring on-site over home visits for feasibility. Caregivers valued growth monitoring, interacting with HCW's, and nutritional supplementation. While unfamiliar with SQ-LNS, caregivers viewed it positively based on their experience with therapeutic foods. Three delivery models were tested: (1) weekly visits for one month transitioning to fortnightly thereafter, (2) fortnightly visits and program days, and (3) fortnightly visits for caregivers and weekly program days at the health site. Model three proved most feasible for caregivers and providers. CONCLUSION: This formative research informed a program design that aligns with caregiver preferences and health system capacity, requiring minimal external support. Fortnightly post-discharge monitoring paired with SQ-LNS supplementation at treatment sites is recommended. CI - (c) 2026. The Author(s). FAU - Heymsfield, Grace AU - Heymsfield G AD - International Rescue Committee, New York, NY, USA. grace.heymsfield@rescue.org. FAU - Kangas, Suvi T AU - Kangas ST AD - International Rescue Committee, Brussels, Belgium. FAU - Cichon, Bernardette AU - Cichon B AD - International Rescue Committee, London, UK. FAU - Coulibaly, Issa Niamanto AU - Coulibaly IN AD - International Rescue Committee, Bamako, Mali. FAU - Diarra, Niele Hawa AU - Diarra NH AD - International Rescue Committee, Bamako, Mali. FAU - Diassana, Koniba AU - Diassana K AD - International Rescue Committee, Bamako, Mali. FAU - Haidara, Alhousseyni AU - Haidara A AD - International Rescue Committee, Bamako, Mali. FAU - Ouologuem, Bareye AU - Ouologuem B AD - Sub-division of Nutrition, Ministry of Health, Bamako, Mali. FAU - Diarra, Samba AU - Diarra S AD - University of Sciences, Techniques and Technologies of Bamako, Bamako, Mali. FAU - Kodish, Stephen AU - Kodish S AD - Penn State University, Penn State, University Park, PA, USA. LA - eng PT - Journal Article DEP - 20260703 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Lipids) SB - IM MH - Humans MH - Mali MH - Qualitative Research MH - *Severe Acute Malnutrition/prevention & control MH - Infant MH - Child, Preschool MH - *Patient Discharge MH - *Dietary Supplements MH - Recurrence MH - Focus Groups MH - Female MH - Male MH - *Lipids/administration & dosage MH - Interviews as Topic MH - Caregivers/psychology PMC - PMC13445792 OTO - NOTNLM OT - Acceptability OT - Feasibility OT - Formative research OT - Mali OT - Severe acute malnutrition (SAM) OT - Small-quantity lipid-based nutrient supplement (SQ-LNS) COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the Institutional Review Board of the International Rescue Committee (H 1.00.080) and the Ethical Committee of the University of Sciences, Techniques and Technologies of Bamako (N.2024/211/USTTB). The study was conducted in accordance with the Declaration of Helsinki. Informed oral consent was obtained from participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/04 00:33 MHDA- 2026/08/07 06:35 PMCR- 2026/07/03 CRDT- 2026/07/03 23:56 PHST- 2025/12/01 00:00 [received] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/08/07 06:35 [medline] PHST- 2026/07/04 00:33 [pubmed] PHST- 2026/07/03 23:56 [entrez] PHST- 2026/07/03 00:00 [pmc-release] AID - 10.1186/s12889-026-28378-x [pii] AID - 28378 [pii] AID - 10.1186/s12889-026-28378-x [doi] PST - epublish SO - BMC Public Health. 2026 Jul 3;26(1):2296. doi: 10.1186/s12889-026-28378-x. PMID- 42399820 OWN - NLM STAT- MEDLINE DCOM- 20261004 LR - 20261007 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 4 TI - Nomogram for predicting 6-month BMIZ changes in children with Crohn's disease: a single-center retrospective study. LID - 10.1186/s12887-026-07258-8 [doi] LID - 936 AB - BACKGROUND: Perianal disease (PD) is an aggressive phenotype in children with Crohn's disease (CD), but its measurable impact on short-term nutritional recovery remains understudied. This study aimed to evaluate the independent effect of PD on the 6-month Body Mass Index Z-score (BMIZ) trajectory and to develop a practical nomogram for early risk stratification in pediatric CD. METHODS: A single-center retrospective cohort of 51 pediatric CD patients (29 with PD and 22 without PD) with at least 6 months of follow-up was enrolled from a tertiary hospital in Fujian, southern China, between July 2017 and March 2025. BMIZ trajectories over time were estimated using linear mixed models (LMM). Predictors of 6-month DeltaBMIZ were screened using univariate regression (P < 0.20), followed by LASSO regression (tenfold cross-validation) to construct a nomogram. Model performance was internally validated using 1000 bootstrap resamples (R(2), MAE, RMSE) and calibration plots. Decision curve analysis (DCA) was performed to evaluate clinical utility for predicting inadequate nutritional recovery (DeltaBMIZ 20) among the SWE parameters, TM thickness emerged as the strongest independent predictor of malnutrition (OR = 0.428, p < 0.001). ROC analyses demonstrated that TM thickness yielded the highest diagnostic accuracy (AUC = 0.887). A cut-off value of approximately 11.15 mm for this parameter provided a sensitivity of 82.9% and specificity of 90.7%. The DeLong test results confirmed that the discriminatory power of TM thickness was statistically superior to that of the elastography data. CONCLUSIONS: TM thickness measurement via B-mode ultrasound is a practical, reproducible, and promising adjunctive point-of-care parameter for detecting malnutrition-induced muscle atrophy in pediatric patients, demonstrating superiority over SWE parameters; however, external multicenter validation is warranted before routine clinical implementation. CI - (c) 2026 Wiley Periodicals LLC. FAU - Ayvaz, Huseyin AU - Ayvaz H AUID- ORCID: 0000-0003-0267-3295 AD - Department of Radiology, Division of Pediatric Radiology, Inonu University Faculty of Medicine, Malatya, Turkey. FAU - Tasolar, Sevgi Demiroz AU - Tasolar SD AUID- ORCID: 0000-0002-9836-6814 AD - Department of Radiology, Division of Pediatric Radiology, Inonu University Faculty of Medicine, Malatya, Turkey. FAU - Gok, Emre AU - Gok E AUID- ORCID: 0000-0001-9458-8076 AD - Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Inonu University Faculty of Medicine, Malatya, Turkey. FAU - Gungor, Sukru AU - Gungor S AUID- ORCID: 0000-0002-0433-5970 AD - Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Inonu University Faculty of Medicine, Malatya, Turkey. FAU - Varol, Fatma Ilknur AU - Varol FI AUID- ORCID: 0000-0001-5212-218X AD - Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Inonu University Faculty of Medicine, Malatya, Turkey. FAU - Tasolar, Mehmet Hakan AU - Tasolar MH AUID- ORCID: 0000-0002-5657-7170 AD - Department of Cardiology, Inonu University Faculty of Medicine, Malatya, Turkey. LA - eng PT - Journal Article DEP - 20260703 PL - United States TA - J Clin Ultrasound JT - Journal of clinical ultrasound : JCU JID - 0401663 SB - IM OTO - NOTNLM OT - muscle atrophy OT - pediatric malnutrition OT - shear wave elastography OT - temporal muscle OT - ultrasonography EDAT- 2026/07/04 00:33 MHDA- 2026/07/04 00:33 CRDT- 2026/07/03 21:42 PHST- 2026/06/20 00:00 [revised] PHST- 2026/04/07 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/07/04 00:33 [medline] PHST- 2026/07/04 00:33 [pubmed] PHST- 2026/07/03 21:42 [entrez] AID - 10.1002/jcu.70320 [doi] PST - aheadofprint SO - J Clin Ultrasound. 2026 Jul 3. doi: 10.1002/jcu.70320. PMID- 42398892 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261023 IS - 1953-8022 (Electronic) IS - 1246-7820 (Linking) VI - 33 IP - 4 DP - 2026 Nov TI - Albumin priming enables safe and effective red blood cell exchange in low-weight children with sickle cell disease. PG - 229-234 LID - S1246-7820(26)00099-6 [pii] LID - 10.1016/j.tracli.2026.06.011 [doi] AB - Red blood cell (RBC) exchanges (RCE) are particularly efficient to treat and prevent complications in patients with sickle cell anemia (SCA). However, the low-weight of young children is a barrier to their use. Spectra Optia is a therapeutic apheresis platform that enables automatic priming to prevent hemodynamic complications in low-weight children. The easiest method is to use albumin for priming, which is allowed by the software. We conducted a retrospective monocenter analysis of the feasibility, safety, and efficacy of albumin priming during RCE (RCE/Alb-primed) in 19 children weighing 12 to 23kg for a total of 153 sessions. They were treated either on an emergency basis (8 children, 8 sessions), before surgery (2 children, 4 sessions) or as part of a RCE program (9 children, 141 sessions). Indications of RCE/Alb-primed sessions included: (i) an extracorporeal volume of the kit equal to 15% of the child's total blood volume; (ii) a weight of less than 20kg; or (iii) a weight between 20 and 25kg with a hematocrit (Hct) of 20% or less. We monitored Grade 2 adverse events (AEs) during the sessions, in extenso decreased blood pressure, increased heart rate and fatigue. Post-apheresis hematocrit and the fraction of cell remaining (FCR) values after RCE were compared to the expected ones. A low incidence of complications was observed in the 153 RCE/Alb-primed sessions with only 1 episodes of transient Grade 2 AEs. Post-apheresis Hct and FCR reached expected values with the RCE/Alb-primed method. In conclusion, RCE/Alb-primed seems to be safe and efficient in young SCA children and should be proposed systematically for curative RCE or prophylactic programs. CI - Copyright (c) 2026 Societe francophone de transfusion sanguine (SFTS). Published by Elsevier Masson SAS. All rights reserved. FAU - Hequet, O AU - Hequet O AD - Service d'Apherese, etablissement francais du sang Rhone Alpes, centre hospitalier Lyon Sud, Pierre-Benite, France; Inserm U1111, CIRI, Centre International for Infectiology Research, universite de Lyon, Lyon, France. Electronic address: olivier.hequet@efs.sante.fr. FAU - Revesz, D AU - Revesz D AD - Service d'Apherese, etablissement francais du sang Rhone Alpes, centre hospitalier Lyon Sud, Pierre-Benite, France. FAU - Chelghoum, Y AU - Chelghoum Y AD - Service d'Apherese, etablissement francais du sang Rhone Alpes, centre hospitalier Lyon Sud, Pierre-Benite, France. FAU - Kebaili, K AU - Kebaili K AD - Institut d'hematologie et d'oncologie pediatrique, hospices civils de Lyon, Lyon, France. FAU - Peugnet, A L AU - Peugnet AL AD - Institut d'hematologie et d'oncologie pediatrique, hospices civils de Lyon, Lyon, France; Laboratoire interuniversitaire de biologie de la motricite (LIBM) EA7424, equipe "Biologie vasculaire et du globule rouge", universite Claude-Bernard Lyon 1, Lyon, France. FAU - Villars, A AU - Villars A AD - Service immuno-hematologie et distribution, etablissement francais du sang Auvergne Rhone Alpes, centre hospitalier Edouard-Herriot, Lyon, France. FAU - Baud, C AU - Baud C AD - Service immuno-hematologie et distribution, etablissement francais du sang Auvergne Rhone Alpes, centre hospitalier Lyon Sud, Lyon, France. FAU - Cognasse, F AU - Cognasse F AD - Departement scientifique, etablissement francais du sang Auvergne-Rhone-Alpes, Saint-Etienne, France; Inserm U1059 SAINBIOSE, universite Jean-Monnet, mines Saint-Etienne, Saint-Etienne, France. FAU - Guironnet-Paquet, A AU - Guironnet-Paquet A AD - Service d'Apherese, etablissement francais du sang Rhone Alpes, centre hospitalier Lyon Sud, Pierre-Benite, France; Inserm U1111, CIRI, Centre International for Infectiology Research, universite de Lyon, Lyon, France. FAU - Halfon-Domenech, C AU - Halfon-Domenech C AD - Institut d'hematologie et d'oncologie pediatrique, hospices civils de Lyon, Lyon, France. FAU - Joly, P AU - Joly P AD - Laboratoire interuniversitaire de biologie de la motricite (LIBM) EA7424, equipe "Biologie vasculaire et du globule rouge", universite Claude-Bernard Lyon 1, Lyon, France; Laboratoire de biologie medicale multi-site. service de biochimie et biologie moleculaire, hospices civils de Lyon, Lyon, France; Laboratoire d'excellence sur le globule rouge (Labex GR-Ex), Paris, France. FAU - Connes, P AU - Connes P AD - Laboratoire interuniversitaire de biologie de la motricite (LIBM) EA7424, equipe "Biologie vasculaire et du globule rouge", universite Claude-Bernard Lyon 1, Lyon, France; Laboratoire d'excellence sur le globule rouge (Labex GR-Ex), Paris, France. LA - eng PT - Journal Article DEP - 20260703 PL - France TA - Transfus Clin Biol JT - Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine JID - 9423846 RN - 0 (Albumins) SB - IM MH - Humans MH - *Anemia, Sickle Cell/therapy/blood MH - Retrospective Studies MH - *Erythrocyte Transfusion/methods/adverse effects MH - Female MH - Male MH - Child, Preschool MH - Child MH - *Albumins/administration & dosage/therapeutic use MH - Hematocrit MH - Feasibility Studies MH - Body Weight MH - Adolescent MH - Blood Component Removal/methods OTO - NOTNLM OT - Priming OT - Red blood cell exchange OT - Sickle cell disease EDAT- 2026/07/04 00:33 MHDA- 2026/10/23 23:30 CRDT- 2026/07/03 19:39 PHST- 2026/05/05 00:00 [received] PHST- 2026/06/28 00:00 [revised] PHST- 2026/06/30 00:00 [accepted] PHST- 2026/10/23 23:30 [medline] PHST- 2026/07/04 00:33 [pubmed] PHST- 2026/07/03 19:39 [entrez] AID - S1246-7820(26)00099-6 [pii] AID - 10.1016/j.tracli.2026.06.011 [doi] PST - ppublish SO - Transfus Clin Biol. 2026 Nov;33(4):229-234. doi: 10.1016/j.tracli.2026.06.011. Epub 2026 Jul 3. PMID- 42397854 OWN - NLM STAT- Publisher LR - 20260703 IS - 1476-8305 (Electronic) IS - 1028-415X (Linking) DP - 2026 Jul 3 TI - Integrated analysis of nutrition profiles and dried blood spot proteomics reveals patterns associated with autism spectrum disorder. PG - 1-16 LID - 10.1080/1028415X.2026.2684633 [doi] AB - OBJECTIVES: To investigate whether dietary behavior-derived nutritional profiles and proteomic analysis of dried blood spots (DBS) could identify patterns associated with autism spectrum disorder (ASD). METHODS: A total of 29 children with ASD (mean age, 56.0 +/- 8.7 months; 23 boys) and 27 control children (mean age, 60.6 +/- 9.5 months; 20 boys) participated in the study. Three-day food records were used to assess nutrient and food group intakes. Blood samples were collected as DBS. To evaluate group separation, partial least squares discriminant analysis was applied to food group data, nutrient intake, and proteomic data. Balanced accuracy (average of sensitivity and specificity) was estimated using 5-fold cross-validation (100 repeats). Candidate markers were selected based on variable importance in projection (VIP) scores, followed by pathway enrichment analysis of proteomic candidates. Tripartite relationships among candidate nutritional and proteomic markers and clinical measures (Childhood Autism Rating Scale; Aberrant Behavior Checklist; Social Responsiveness Scale; Full-Scale IQ; Vineland Adaptive Behavior Scales) were explored using correlation heatmaps. RESULTS: We prioritized 18 candidate nutritional markers and 10 proteomic markers. The proteins were significantly enriched in nervous system pathways. Correlation analyses revealed several tripartite relationships among nutritional markers, proteomic markers, and clinical measures, including an S100A6-(omega-6 intake or meat intake)-clinical measures relationship and an ALDH18A1-nuts/seeds intake-clinical measures relationship. DISCUSSION: Specific combinations of nutritional profiles and DBS-derived proteomic signatures were associated with symptom severity and functional outcomes in children with ASD. Dietary intake may help interpret these molecular and clinical patterns. Future studies are necessary to elucidate these interrelationships. FAU - Kwon, Hoshik AU - Kwon H AUID- ORCID: 0009-0001-0591-2696 AD - Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. FAU - Yoon, Su-In AU - Yoon SI AD - Department of Food and Nutrition, Chungnam National University, Daejeon, Republic of Korea. FAU - Baek, Sooyeon AU - Baek S AD - Department of Food and Nutrition, Chungnam National University, Daejeon, Republic of Korea. FAU - Hyun, Yerin AU - Hyun Y AD - Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. FAU - Kim, Ju Yeon AU - Kim JY AD - Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. FAU - Park, Dong Hui AU - Park DH AD - Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. FAU - Yu, Jiyoung AU - Yu J AD - Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. FAU - Cho, Jin Ah AU - Cho JA AD - Department of Food and Nutrition, Chungnam National University, Daejeon, Republic of Korea. AD - Glocal Life Care Convergence Program, Interdisciplinary Education Center for the Innovative Next Generation Leaders in Glocal Lifecare, Chungnam National University, Daejeon, Republic of Korea. FAU - Kim, Hyo-Won AU - Kim HW AD - Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. FAU - Kim, Kyunggon AU - Kim K AD - Convergence Medicine Research Center, Asan Institute for Life Sciences, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. AD - Department of Medical Informatics and Statistics, Brain Korea 21 plus, University of Ulsan College of Medicine, Seoul, Republic of Korea. LA - eng PT - Journal Article DEP - 20260703 PL - England TA - Nutr Neurosci JT - Nutritional neuroscience JID - 100892202 SB - IM OTO - NOTNLM OT - Autism spectrum disorder OT - nutrition OT - proteomics EDAT- 2026/07/03 18:34 MHDA- 2026/07/03 18:34 CRDT- 2026/07/03 13:42 PHST- 2026/07/03 18:34 [medline] PHST- 2026/07/03 18:34 [pubmed] PHST- 2026/07/03 13:42 [entrez] AID - 10.1080/1028415X.2026.2684633 [doi] PST - aheadofprint SO - Nutr Neurosci. 2026 Jul 3:1-16. doi: 10.1080/1028415X.2026.2684633. PMID- 42397661 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261015 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Jul 3 TI - An interactive web-based tool for computing BMI standard deviation scores in Italian children and adolescents using national growth references. LID - 10.1007/s40519-026-01887-9 [doi] LID - 86 AB - BACKGROUND: Body mass index (BMI) standard deviation scores (SDS) are essential for age- and sex-adjusted assessments in pediatric populations, including growth trajectories. Their accuracy depends on the use of population-specific reference data, as BMI distributions vary substantially across countries. Despite the availability of internationally recognized growth standards, no accessible computational tool tailored to Italian normative data has been previously described. OBJECTIVES: This paper describes the development and validation of an interactive, freely accessible web-based calculator for deriving BMI-SDS in Italian children and adolescents, based on the nationally representative Cacciari et al. (2006) growth reference dataset. METHODS: BMI-SDS computation is based on the LMS parameterization of Italian reference curves, which provide sex-specific L (skewness), M (median), and S (coefficient of variation) values at half-year age intervals from 2 to 20 years for a nationally representative Italian sample of approximately 70,000 children and adolescents. RESULTS: The tool was implemented in R using the Shiny web application framework and is hosted at https://turius.shinyapps.io/BMI_SDS_IT/ . Given user-entered weight, height, age, and sex, the tool computes BMI (kg/m(2)), derives the corresponding BMI-SDS and returns i) age- and sex-adjusted BMI-SDS; ii) the corresponding percentile; iii) a graphical representation of the individual's position on the reference distribution. CONCLUSIONS: The tool offers a straightforward, clinician- and researcher-friendly interface for computing age- and sex-standardized BMI scores using Italian-specific references, supporting more accurate weight-status classification in both clinical practice and epidemiological research. CI - (c) 2026. The Author(s). FAU - Tarchi, Livio AU - Tarchi L AUID- ORCID: 0000-0002-9931-5621 AD - Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Viale Pieraccini, 6, Florence, FI, Italy. livio.tarchi@unifi.it. AD - Department of Health Sciences, University of Florence, Florence, FI, Italy. livio.tarchi@unifi.it. AD - University Hospital of Florence, Florence, FI, Italy. livio.tarchi@unifi.it. FAU - Mattesini, Elena AU - Mattesini E AD - Department of Health Sciences, University of Florence, Florence, FI, Italy. FAU - Dani, Cristiano AU - Dani C AD - Department of Neuroscience, Psychology, Drug Research and Child Health, University of Florence, Viale Pieraccini, 6, Florence, FI, Italy. AD - Department of Health Sciences, University of Florence, Florence, FI, Italy. FAU - D'Areglia, Eleonora AU - D'Areglia E AD - University Hospital of Florence, Florence, FI, Italy. FAU - Castellini, Giovanni AU - Castellini G AD - Department of Health Sciences, University of Florence, Florence, FI, Italy. AD - University Hospital of Florence, Florence, FI, Italy. FAU - Ricca, Valdo AU - Ricca V AD - Department of Health Sciences, University of Florence, Florence, FI, Italy. AD - University Hospital of Florence, Florence, FI, Italy. LA - eng GR - PE0000006/Ministero dell'Universita e della Ricerca/ PT - Journal Article DEP - 20260703 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - Adolescent MH - *Body Mass Index MH - Child MH - Female MH - Italy MH - Male MH - Internet MH - Reference Values MH - Child, Preschool MH - Young Adult MH - Growth Charts MH - Body Weight/physiology MH - Software PMC - PMC13658362 OTO - NOTNLM OT - Anorexia OT - BMI z-score OT - Growth curve OT - Obesity OT - Overweight OT - Underweight OT - Weight COIS- Declarations. Ethics approval and consent to participate: Not applicable. The project does not involve testing on human subjects, user studies, or gathering data from users. The software analyzes or utilizes data that are already in the public domain and fully anonymized. The project does not process personally identifiable information or sensitive data. The software is not a diagnostic tool or part of a clinical trial. Competing interests: The authors declare no competing interests. EDAT- 2026/07/03 12:32 MHDA- 2026/10/13 05:31 PMCR- 2026/07/03 CRDT- 2026/07/03 11:16 PHST- 2026/03/20 00:00 [received] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/10/13 05:31 [medline] PHST- 2026/07/03 12:32 [pubmed] PHST- 2026/07/03 11:16 [entrez] PHST- 2026/07/03 00:00 [pmc-release] AID - 10.1007/s40519-026-01887-9 [pii] AID - 1887 [pii] AID - 10.1007/s40519-026-01887-9 [doi] PST - epublish SO - Eat Weight Disord. 2026 Jul 3;31(1):86. doi: 10.1007/s40519-026-01887-9. PMID- 42396673 OWN - NLM STAT- Publisher LR - 20260717 IS - 1475-2719 (Electronic) IS - 0029-6651 (Linking) DP - 2026 Jul 3 TI - Using positive social influences to increase children's vegetable intake. PG - 1-9 LID - 10.1017/S0029665126105060 [doi] AB - Despite the established health benefits of vegetables, most children do not consume enough to meet dietary recommendations. Early childhood is a critical period for shaping lifelong eating habits, and social eating experiences play an important role in this learning. This review synthesises evidence on how positive social influences support children's vegetable intake. Findings across shared eating occasions, positive eating atmosphere, modelling and social facilitation demonstrate that social experiences shape healthy dietary behaviour, including vegetable intake. The review also highlights the importance of individual differences, including children's eating behaviours and household characteristics such as socioeconomic status, food insecurity and household chaos, which may influence both the feasibility and effectiveness of creating positive social eating environments. In addition, the review identifies key opportunities for intervention and emphasises the need for more longitudinal research to understand how social eating processes evolve across development. Together, the evidence underscores the potential of positive social influences to enhance children's vegetable consumption and supports the development of tailored, socially grounded nutrition interventions. FAU - Edwards, Katie L AU - Edwards KL AUID- ORCID: 0000-0003-1076-8382 AD - School of Psychology, https://ror.org/03angcq70University of Birmingham, UK. FAU - Higgs, Suzanne AU - Higgs S AD - School of Psychology, https://ror.org/03angcq70University of Birmingham, UK. LA - eng PT - Journal Article PT - Review DEP - 20260703 PL - England TA - Proc Nutr Soc JT - The Proceedings of the Nutrition Society JID - 7505881 SB - IM OTO - NOTNLM OT - Children's eating OT - Eating atmosphere OT - Modelling OT - Social influences OT - Vegetable intake EDAT- 2026/07/03 06:31 MHDA- 2026/07/03 06:31 CRDT- 2026/07/03 05:52 PHST- 2026/07/03 06:31 [pubmed] PHST- 2026/07/03 06:31 [medline] PHST- 2026/07/03 05:52 [entrez] AID - S0029665126105060 [pii] AID - 10.1017/S0029665126105060 [doi] PST - aheadofprint SO - Proc Nutr Soc. 2026 Jul 3:1-9. doi: 10.1017/S0029665126105060. PMID- 42396129 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260703 LR - 20260813 IS - 3050-2225 (Electronic) IS - 3050-2225 (Linking) VI - 13 DP - 2026 Jan-Dec TI - Implementation of Child Life Services in Pediatric HSCT: A Pilot Study From Thailand. PG - 30502225261466108 LID - 10.1177/30502225261466108 [doi] LID - 30502225261466108 AB - BACKGROUND: Despite improved survival after pediatric hematopoietic stem cell transplantation (HSCT) in Thailand, many children experience physical and psychological distress. This pilot study evaluated the feasibility of a child life program and its preliminary effects on outcomes. METHODS: This pilot pre-post study included 10 children aged 2-8 years undergoing HSCT. The program comprised an HSCT educational video, therapeutic play, art therapy, online group activities, and homebound instruction after discharge. Outcomes were assessed at baseline and 6 months using the Pediatric Quality of Life Inventory (PedsQL), Child Behavior Checklist (CBCL), and Parenting Stress Index (PSI). Changes were analyzed using paired t-tests. RESULTS: PedsQL total, nausea, and nutrition scores improved significantly. PSI difficult child scores decreased slightly, whereas CBCL scores showed no significant changes. Six children returned to school within one year. CONCLUSION: Child life services were feasible and showed potential to improve short-term quality of life in HSCT patients. CI - (c) The Author(s) 2026. FAU - Yooyen, Keerati AU - Yooyen K AD - Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. RINGGOLD: 26687 FAU - Chuchottaworn, Kanokphan AU - Chuchottaworn K AD - Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. RINGGOLD: 26687 FAU - Pakakasama, Samart AU - Pakakasama S AD - Division of Hematology and Oncology, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. RINGGOLD: 26687 FAU - Chuthapisith, Jariya AU - Chuthapisith J AUID- ORCID: 0000-0001-7571-919X AD - Division of Developmental and Behavioral Pediatrics, Department of Pediatrics, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand. RINGGOLD: 26687 LA - eng PT - Journal Article DEP - 20260701 PL - United States TA - Sage Open Pediatr JT - Sage open pediatrics JID - 9919052035406676 PMC - PMC13323666 OTO - NOTNLM OT - HSCT OT - child life services OT - pediatric oncology OT - psychosocial intervention COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/07/03 10:11 MHDA- 2026/07/03 10:12 PMCR- 2026/07/01 CRDT- 2026/07/03 05:28 PHST- 2026/03/12 00:00 [received] PHST- 2026/05/07 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/07/03 10:12 [medline] PHST- 2026/07/03 10:11 [pubmed] PHST- 2026/07/03 05:28 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 10.1177_30502225261466108 [pii] AID - 10.1177/30502225261466108 [doi] PST - epublish SO - Sage Open Pediatr. 2026 Jul 1;13:30502225261466108. doi: 10.1177/30502225261466108. eCollection 2026 Jan-Dec. PMID- 42395617 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260703 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Establishment of a CT-based prediction model for endotracheal tube size in infants aged <1 year. PG - 1796799 LID - 10.3389/fped.2026.1796799 [doi] LID - 1796799 AB - OBJECTIVE: By quantifying airway parameters on computed tomography (CT) and incorporating clinical factors such as age and prematurity, this study developed an airway prediction model for infants to provide more accurate guidance for endotracheal tube size selection and insertion depth in patients under one year of age. METHODS: A retrospective analysis of data on infants under one year of age who underwent preoperative anesthesia evaluation at Peking University People's Hospital from January 2020 to December 2022. Inclusion criteria: All enrolled infants underwent chest CT examination, with the scanning range covering the level of the cricoid cartilage. The development of cricoid cartilage was associated with laryngeal cartilage maturity. Its size and ossification degree change with age, sex, height and other factors. Therefore, we collected clinical data including the age, sex, gestational age, preterm birth, height and weight at birth and visit which may affect the shortest diameter of the cricoid cartilage in children. Infants with congenital laryngeal malformations, acquired nutritional deficiencies, hormonal abnormalities such as hypothyroidism, neck tumors and a history of maternal smoking during pregnancy were excluded. Accurately measure the shortest inner diameter of the cricoid cartilage and the distance from the cricoid cartilage to the carina on CT images. SPSS 24.0 software was used for simple and multiple linear regression analysis to screen key factors. Corresponding prediction models were established for the shortest cricoid cartilage diameter and the cricoid-to-carina distance, so as to facilitate the individualized selection of tracheal tube sizes and insertion depths in clinical practice. RESULTS: In this study, age and preterm birth were identified as independent influencing factors for the shortest cricoid cartilage diameter in infants [P = 0.008, 0.005(95% CI: 0.001 to 0.008); P = 0.022, -1.261 (95% CI: -2.321 to -0.201)]. The established prediction formulas were as follows: the shortest diameter of the cricoid cartilage in full-term infants (mm) = 6.119 + 0.005 x age; The shortest diameter of the cricoid cartilage in preterm infants (mm) = 6.119 + 0.005 x age-1.261. For the distance from the cricoid cartilage to the carina, age was the only significant influencing factor [P = 0.003, 35.725(95% CI: 0.016 to 0.073)], and carina formula was derived as follows: distance from the cricoid cartilage to the carina (mm) = 35.725 + 0.044 x age. CONCLUSION: Age and preterm status were independently associated with the shortest cricoid cartilage diameter in infants under one year of age, suggesting that preterm infants may require smaller endotracheal tubes than full-term infants of the same age. Age was also associated with the cricoid-to-carina distance. These CT-based findings may support more individualized airway management in infants. However, despite internal bootstrap validation, the model remains limited by the lack of external validation, small sample size, and highly specific ophthalmologic surgical population; therefore, broader validation is required before clinical generalization. CI - (c) 2026 Li, Sun, Wu and Tian. FAU - Li, Yan AU - Li Y AD - Department of Anesthesiology, Peking University People's Hospital, Beijing, China. FAU - Sun, Chao AU - Sun C AD - Department of Radiology, Peking University People's Hospital, Beijing, China. AD - Department of Medical Information Center, Peking University People's Hospital, Beijing, China. FAU - Wu, Yanqiu AU - Wu Y AD - Department of Medical Information Center, Peking University People's Hospital, Beijing, China. FAU - Tian, Xue AU - Tian X AD - Department of Anesthesiology, Peking University People's Hospital, Beijing, China. LA - eng PT - Journal Article DEP - 20260618 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13323497 OTO - NOTNLM OT - chest CT OT - cricoid cartilage OT - infants OT - preterm infants OT - tracheal intubation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/03 06:31 MHDA- 2026/07/03 06:32 PMCR- 2026/06/18 CRDT- 2026/07/03 05:25 PHST- 2026/01/27 00:00 [received] PHST- 2026/05/03 00:00 [revised] PHST- 2026/05/13 00:00 [accepted] PHST- 2026/07/03 06:32 [medline] PHST- 2026/07/03 06:31 [pubmed] PHST- 2026/07/03 05:25 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.3389/fped.2026.1796799 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 18;14:1796799. doi: 10.3389/fped.2026.1796799. eCollection 2026. PMID- 42395293 OWN - NLM STAT- MEDLINE DCOM- 20260703 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Mediating role of exercise behavioral intention in the relationship between exercise self-efficacy and physical activity levels in vocational education students. PG - 1833167 LID - 10.3389/fpubh.2026.1833167 [doi] LID - 1833167 AB - BACKGROUND: Social Cognitive Theory and the Theory of Planned Behavior suggest that self-efficacy influences physical activity through behavioral intention; however, evidence in vocational students is scarce. OBJECTIVE: This study examined whether exercise behavioral intention mediates the association between exercise self-efficacy and physical activity levels among vocational education students in Shanghai. METHODS: A cross sectional survey was conducted with 992 students from four vocational colleges. Participants completed validated measures of exercise self-efficacy (nine items, 1-10 scale), exercise behavioral intention (five items, 5-point Likert scale), and physical activity (IPAQ-SF). Data were analyzed using SPSS 25.0 (IBM Corporation, Armonk, New York, USA) and AMOS 26.0 (IBM Corporation, Armonk, New York, USA), adjusting for gender, age, and education level. RESULTS: Exercise self-efficacy was positively associated with exercise behavioral intention (r = 0.612, p < 0.001) and physical activity (r = 0.322, p < 0.001). Mediation analysis showed that behavioral intention partially mediated this relationship (indirect effect = 0.122, 95% CI [0.085, 0.163]), accounting for 45.19% of the total effect. CONCLUSION: Exercise self-efficacy is associated with physical activity both directly and indirectly via behavioral intention in vocational students. Interventions enhancing self-efficacy and behavioral intention may support higher activity levels, though longitudinal studies are needed to confirm directionality. CI - Copyright (c) 2026 Jing, Zhai, Xu, Wu and Wang. FAU - Jing, Ziyang AU - Jing Z AD - Shanghai Technician School, Shanghai University of Engineering Science, Shanghai, China. FAU - Zhai, Rongxuan AU - Zhai R AD - Department of Sports Medicine, Sport and Health Research Center, Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Physical Education Department, Tongji University, Shanghai, China. FAU - Xu, Zihan AU - Xu Z AD - School of Public Administration, Hangzhou Normal University, Hangzhou, China. FAU - Wu, Xudong AU - Wu X AD - Shanghai Technician School, Shanghai University of Engineering Science, Shanghai, China. FAU - Wang, Lejun AU - Wang L AD - Department of Sports Medicine, Sport and Health Research Center, Shanghai YangZhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), Physical Education Department, Tongji University, Shanghai, China. LA - eng PT - Journal Article DEP - 20260618 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Self Efficacy MH - *Intention MH - Female MH - *Exercise/psychology MH - Male MH - Cross-Sectional Studies MH - *Students/psychology/statistics & numerical data MH - *Vocational Education MH - China MH - Young Adult MH - Surveys and Questionnaires MH - Adult MH - Theory of Planned Behavior MH - Adolescent PMC - PMC13323127 OTO - NOTNLM OT - exercise behavioral intention OT - exercise self-efficacy OT - mediating effect OT - physical activity OT - vocational education students COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/03 06:31 MHDA- 2026/07/03 16:10 PMCR- 2026/06/18 CRDT- 2026/07/03 05:20 PHST- 2026/03/18 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/07/03 16:10 [medline] PHST- 2026/07/03 06:31 [pubmed] PHST- 2026/07/03 05:20 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1833167 [doi] PST - epublish SO - Front Public Health. 2026 Jun 18;14:1833167. doi: 10.3389/fpubh.2026.1833167. eCollection 2026. PMID- 42395143 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260703 LR - 20260813 IS - 2475-0328 (Electronic) IS - 2475-0328 (Linking) VI - 10 IP - 4 DP - 2026 Jul TI - Preoperative Total Iron-Binding Capacity Is a Novel Surrogate Marker of Short- and Long-Term Outcomes After Liver Resection for Hepatocellular Carcinoma. PG - 1280-1288 LID - 10.1002/ags3.70206 [doi] AB - BACKGROUND: This study aimed to examine whether preoperative serum total iron-binding capacity (TIBC), which is directly proportional to transferrin level, correlates with short- and long-term outcomes after hepatectomy. METHODS: Preoperative TIBC levels, calculated by summing serum iron and unsaturated iron binding capacity, were evaluated in 577 patients who underwent hepatectomy for hepatocellular carcinoma. We defined TIBC < 274 mug/dL calculated by receiver-operating characteristic (ROC) analysis as low TIBC. We evaluated the relationship between preoperative TIBC levels and short- and long-term outcomes after hepatectomy. RESULTS: Low preoperative TIBC levels were correlated with lower body mass index, worse Child Pugh score, lower albumin, higher CRP, lower hemoglobin, lower serum iron, higher controlling nutritional status (CONUT) score, lower prognostic nutritional index (PNI), and larger tumor size compared to those in high TIBC levels (p = 0.0070, 0.0098, < 0.0001, 0.0008, 0.0086, 0.0018, 0.0008, < 0.0001, and 0.016, respectively). Patients with low preoperative TIBC levels experienced significantly more frequent postoperative complications of Clavien-Dindo classification (CDc) >/= II and III in univariate and multivariate analyses (CDc>/=II; hazard ratio [HR] 1.69, 95% confidence interval [CI] 1.010-2.799, p = 0.046/CDc>/=III; hazard ratio [HR] 1.92, 95% confidence interval [CI] 1.015-3.506, p = 0.045). Furthermore, these patients were significantly correlated with worse overall survival (OS) and relapse free survival (RFS) in univariate and multivariate analyses (OS; HR 3.24, 95% CI 1.783-5.805, p = 0.0002/RFS; HR 1.65, 95% CI 1.009-2.720, p = 0.046). CONCLUSION: Preoperative serum TIBC levels may be a novel surrogate marker of postoperative complications and long-term survival after hepatectomy. CI - (c) 2026 The Author(s). Annals of Gastroenterological Surgery published by John Wiley & Sons Australia, Ltd on behalf of The Japanese Society of Gastroenterological Surgery. FAU - Yamane, Taishi AU - Yamane T AUID- ORCID: 0009-0001-1000-7738 AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. FAU - Hayashi, Hiromitsu AU - Hayashi H AUID- ORCID: 0000-0002-1832-4287 AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. FAU - Ogawa, Daisuke AU - Ogawa D AUID- ORCID: 0000-0001-5500-7996 AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. FAU - Kinoshita, Shotaro AU - Kinoshita S AUID- ORCID: 0000-0002-6690-4702 AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. FAU - Shiraishi, Yuta AU - Shiraishi Y AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. FAU - Yamao, Takanobu AU - Yamao T AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. FAU - Kitano, Yuki AU - Kitano Y AUID- ORCID: 0000-0001-6292-8670 AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. FAU - Miyata, Tatsunori AU - Miyata T AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. FAU - Okabe, Hirohisa AU - Okabe H AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. FAU - Iwatsuki, Masaaki AU - Iwatsuki M AUID- ORCID: 0000-0002-0886-4618 AD - Department of Gastroenterological Surgery Graduate School of Medical Sciences, Kumamoto University Kumamoto Japan. LA - eng PT - Journal Article DEP - 20260225 PL - Japan TA - Ann Gastroenterol Surg JT - Annals of gastroenterological surgery JID - 101718062 PMC - PMC13326819 OTO - NOTNLM OT - hepatocellular carcinoma OT - prognostic marker OT - total iron-binding capacity COIS- Masaaki Iwatsuki is an editorial member of Annals of Gastroenterological Surgery. EDAT- 2026/07/03 06:31 MHDA- 2026/07/03 06:32 PMCR- 2026/02/25 CRDT- 2026/07/03 05:19 PHST- 2025/11/30 00:00 [received] PHST- 2026/02/09 00:00 [revised] PHST- 2026/02/15 00:00 [accepted] PHST- 2026/07/03 06:32 [medline] PHST- 2026/07/03 06:31 [pubmed] PHST- 2026/07/03 05:19 [entrez] PHST- 2026/02/25 00:00 [pmc-release] AID - AGS370206 [pii] AID - 10.1002/ags3.70206 [doi] PST - epublish SO - Ann Gastroenterol Surg. 2026 Feb 25;10(4):1280-1288. doi: 10.1002/ags3.70206. eCollection 2026 Jul. PMID- 42394860 OWN - NLM STAT- MEDLINE DCOM- 20260703 LR - 20260813 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 15 DP - 2026 TI - Development and validation of a food frequency questionnaire for national nutrition surveillance among Malaysian adolescents and adults. PG - e48 LID - 10.1017/jns.2026.10119 [doi] LID - e48 AB - Food habits vary across ethnic groups and geographical regions. However, validated dietary assessment tools accounting for such diversity remain limited. A semi-quantitative food frequency questionnaire (FFQ) was developed and validated to assess the habitual food intake of adolescents and adults across Malaysia. The 147-item FFQ was constructed using commonly consumed foods from five main ethnicities (Malay, Chinese, Indian, and Sabah and Sarawak indigenous groups) identified from national surveys. A cross-sectional validation study was conducted among purposively sampled healthy individuals aged 10-59 years from 16 administrative regions. Trained community nutritionists administered the FFQ to assess monthly intake, alongside a three-day dietary record and recall (3DRR) covering two weekdays and one weekend. Spearman's correlation, Bland-Altman plots, and quartile cross-classification evaluated the agreement between the FFQ and 3DRR for energy, macronutrients, and selected micronutrients (Vitamin C, thiamine, calcium, and iron). Respondents (n = 361; 50.3% adults, 49.7% adolescents) were 50.4% female and represented five main ethnicities (range: 15.8-25.2%), with 60.4% from Peninsular Malaysia. Energy intake estimated by the FFQ (median: 2285 kcal) was significantly higher than by the 3DRR (median: 1785 kcal; Wilcoxon p < 0.001). Spearman's correlation coefficients observed for energy (crude r = 0.31), and selected nutrients (energy-adjusted r range: 0.19-0.38), along with <10% of extreme quartile misclassification indicated acceptable ranking ability and agreement for most nutrients. Bland-Altman plots indicated no proportional bias for energy and macronutrients. In conclusion, the FFQ is a valid tool for assessing dietary intake within the multi-ethnic Malaysian population nationwide. CI - (c) The Author(s) 2026. FAU - Wong, Kimberly Yuin Y'ng AU - Wong KYY AUID- ORCID: 0000-0002-4745-8735 AD - Centre for Nutrition Epidemiology Research, Institute for Public Health, Malaysia. ROR: https://ror.org/05ddxe180 FAU - Zainuddin, Ahmad Ali AU - Zainuddin AA AUID- ORCID: 0000-0003-4016-6809 AD - Centre for Nutrition Epidemiology Research, Institute for Public Health, Malaysia. ROR: https://ror.org/05ddxe180 FAU - Salleh, Ruhaya AU - Salleh R AD - Centre for Nutrition Epidemiology Research, Institute for Public Health, Malaysia. ROR: https://ror.org/05ddxe180 FAU - Palaniveloo, Lalitha AU - Palaniveloo L AD - Centre for Nutrition Epidemiology Research, Institute for Public Health, Malaysia. ROR: https://ror.org/05ddxe180 FAU - Baharudin, Azli AU - Baharudin A AD - Centre for Nutrition Epidemiology Research, Institute for Public Health, Malaysia. ROR: https://ror.org/05ddxe180 FAU - Muhammad, Noor Ul-Aziha AU - Muhammad NU AD - Centre for Nutrition Epidemiology Research, Institute for Public Health, Malaysia. ROR: https://ror.org/05ddxe180 FAU - Amali, Khairul Hasnan AU - Amali KH AD - Centre for Nutrition Epidemiology Research, Institute for Public Health, Malaysia. ROR: https://ror.org/05ddxe180 FAU - Husni Zain, Sulhariza AU - Husni Zain S AUID- ORCID: 0000-0003-4155-8089 AD - Centre for Nutrition Epidemiology Research, Institute for Public Health, Malaysia. ROR: https://ror.org/05ddxe180 FAU - Lai, Wai Kent AU - Lai WK AD - Centre for Nutrition Epidemiology Research, Institute for Public Health, Malaysia. ROR: https://ror.org/05ddxe180 LA - eng PT - Journal Article PT - Validation Study DEP - 20260701 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Adolescent MH - Malaysia MH - Female MH - Adult MH - Male MH - Child MH - Young Adult MH - Energy Intake MH - Cross-Sectional Studies MH - Surveys and Questionnaires/standards MH - *Feeding Behavior MH - Middle Aged MH - *Diet MH - Diet Records MH - *Nutrition Surveys MH - Nutrition Assessment MH - Micronutrients/administration & dosage MH - Nutrients/administration & dosage MH - Reproducibility of Results MH - Ethnicity MH - *Diet Surveys PMC - PMC13323619 OTO - NOTNLM OT - Dietary assessment OT - Food frequency questionnaire OT - Habitual food intake OT - Nutrition epidemiology OT - Validation COIS- All authors declare no conflicts of interest. EDAT- 2026/07/03 06:31 MHDA- 2026/07/03 06:32 PMCR- 2026/07/01 CRDT- 2026/07/03 05:16 PHST- 2025/10/09 00:00 [received] PHST- 2026/05/15 00:00 [revised] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/07/03 06:32 [medline] PHST- 2026/07/03 06:31 [pubmed] PHST- 2026/07/03 05:16 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - S2048679026101190 [pii] AID - 10.1017/jns.2026.10119 [doi] PST - epublish SO - J Nutr Sci. 2026 Jul 1;15:e48. doi: 10.1017/jns.2026.10119. eCollection 2026. PMID- 42393793 OWN - NLM STAT- MEDLINE DCOM- 20260703 LR - 20260813 IS - 1743-0003 (Electronic) IS - 1743-0003 (Linking) VI - 23 IP - 1 DP - 2026 Jul 2 TI - Determination of cut-off points for the Move4 accelerometer and assessment of energy expenditure in children and adolescents aged 6-16 years using manual wheelchairs: a validation and calibration study. LID - 10.1186/s12984-026-02085-5 [doi] LID - 204 AB - BACKGROUND: The present study aimed to determine activity intensity and validate the Move4 accelerometer and derive cut-off points to accurately classify wheelchair-based physical activity (PA) in children and adolescents. METHODS: A calibration and validation study with a test-retest design was performed in 24 children and adolescents (mean age 9.9 +/- 3.2 years; 50% girls) using manual wheelchairs. Participants used a manual wheelchair as their primary mode of mobility and were able propelling the wheelchair independently. Participants completed standardized activities while wearing Move4 sensors at the wrist, upper arm, and chest. In a subsample of 7 children and adolescents, energy expenditure was recorded using portable metabolic cart. Mean Amplitude Deviation (MAD) and Movement Acceleration Intensity (MAI) were processed to derive cut-off points for sedentary, light, moderate, and vigorous PA using CART models, and validity was assessed via Metabolic Equivalent (MET) and heart-rate responses. RESULTS: Both MAD and MAI values increased systematically across activity intensities, supporting good criterion validity. MET values showed progression from sedentary to vigorous tasks. Intensity-specific cut-off points were successfully established for all sensor placements, with consistently higher thresholds for MAI. Sensitivity and specificity analyses indicated the most balanced performance for the upper arm (MAD) and chest (MAI). Test-retest comparisons showed greater variability for MAD-based cut-offs, whereas MAI thresholds demonstrated higher stability, with deviations of approximately 4-5%. CONCLUSIONS: While both MAD and MAI validly reflected PA intensity, MAI showed greater temporal stability and test-retest robustness. These findings support the use of accelerometery for classifying PA in children and adolescents using wheelchairs and underscore the importance of selecting appropriate metrics and sensor positions. CI - (c) 2026. The Author(s). FAU - Seemuller, Selina AU - Seemuller S AD - Department of Sport Science and Sport, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany. Selina.seemueller@fau.de. FAU - Reimers, Anne Kerstin AU - Reimers AK AD - Department of Sport Science and Sport, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany. FAU - Meixner, Benedikt AU - Meixner B AD - Department of Sport Science and Sport, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany. AD - Integrative and Experimental Exercise Science & Training, Julius-Maximilians-Universitat Wurzburg, Wurzburg, Germany. FAU - Engel, Florian AU - Engel F AD - Integrative and Experimental Exercise Science & Training, Julius-Maximilians-Universitat Wurzburg, Wurzburg, Germany. FAU - Beck, Franziska AU - Beck F AD - Department of Sport Science and Sport, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Erlangen, Germany. LA - eng PT - Journal Article PT - Validation Study DEP - 20260702 PL - England TA - J Neuroeng Rehabil JT - Journal of neuroengineering and rehabilitation JID - 101232233 SB - IM MH - Humans MH - Female MH - Child MH - Adolescent MH - *Energy Metabolism/physiology MH - *Accelerometry/instrumentation/methods/standards MH - *Wheelchairs MH - Male MH - Calibration MH - Reproducibility of Results PMC - PMC13330353 COIS- Declarations. Ethics approval and consent to participate: The study was approved by the local Ethics Committee (Ref. No. 24-345-S) and was in accordance with the 1964 Declaration of Helsinki. All the participants or their parents/legal guardians, in case of minors, signed a written informed consent. Consent for publication: All participants gave their written consent. Competing interests: The authors declare no competing interests. EDAT- 2026/07/03 10:10 MHDA- 2026/07/03 10:11 PMCR- 2026/07/02 CRDT- 2026/07/03 00:19 PHST- 2026/02/11 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/07/03 10:11 [medline] PHST- 2026/07/03 10:10 [pubmed] PHST- 2026/07/03 00:19 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - 10.1186/s12984-026-02085-5 [pii] AID - 2085 [pii] AID - 10.1186/s12984-026-02085-5 [doi] PST - epublish SO - J Neuroeng Rehabil. 2026 Jul 2;23(1):204. doi: 10.1186/s12984-026-02085-5. PMID- 42393619 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261009 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jul 3 TI - Exposure to air pollutants is associated with adverse changes in hemoglobin trajectories and an increased risk of anemia in children and adolescents. LID - 10.1186/s12889-026-27895-z [doi] LID - 2837 AB - BACKGROUND: Air pollution is associated with anemia in children, however, longitudinal data supporting this association are insufficient. METHODS: From 2019 to 2023, we conducted a dynamic cohort study involving 33,900 participants from 119 primary and secondary schools across 16 districts in Shanghai. We obtained the daily average concentrations of five air pollutants (PM(2.5), O(3), NO(2), SO(2), and CO) based on school addresses using the China High Air Pollutants (CHAP) dataset to assess the exposure levels of the study subjects. We used latent class mixed models to determine the longitudinal trajectories of hemoglobin (Hb) and multinomial logistic regression models to estimate odds ratios (ORs) and 95% confidence intervals (CIs) between trajectory categories. Linear and logistic regression models were used to evaluate the associations between air pollutant exposure level and Hb and anemia risk, respectively, and Cox regression models was used for longitudinal validation. Interaction terms for gender, age, and body mass index (BMI) were used to explore the modifying effects of these factors. RESULTS: At the baseline survey, 3,213 students (9.48%) were identified as anemic, with a higher proportion of girls (63.8%). During an average follow-up period of 3.16 years, 1,685 participants (4.9%) were observed to develop anemia. Children's hemoglobin levels showed three different trajectory patterns throughout the study period. Exposure to PM(2.5) [OR (95% CI) = 2.124(1.853, 2.433)] was associated with adverse trajectory changes characterized by "low hemoglobin". Longitudinal analysis shows that exposure to PM(2.5) [HR = 1.213, 95% CI: (1.068, 1.376)], NO(2) [HR = 1.409, 95% CI: (1.254, 1.584)], and SO(2) [HR = 1.268, 95% CI: (1.172, 1.372)] is associated with an increased risk of anemia. Stratified analysis showed that the adverse effects of PM(2.5) exposure on anemia were more pronounced in younger or underweight children. The adverse effects of NO(2) exposure on anemia were more significant in older or obese children. The association between SO(2) exposure and the impact on anemia mainly appeared in male or younger children. CONCLUSIONS: Long-term exposure to air pollutants is associated with an increased burden of anemia in children and adolescents, and attention should be focused on vulnerable groups such as girls and underweight children. CI - (c) 2026. The Author(s). FAU - Zheng, Keyang AU - Zheng K AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. FAU - Zhang, Fengyun AU - Zhang F AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. FAU - Chu, Liting AU - Chu L AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. FAU - Yang, Yanting AU - Yang Y AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. FAU - Sun, Lijing AU - Sun L AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. FAU - Huang, Yuting AU - Huang Y AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. FAU - Qu, Shuangxiao AU - Qu S AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. FAU - Huang, Shenglei AU - Huang S AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. FAU - Qi, Wenjuan AU - Qi W AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. FAU - Yang, Dongling AU - Yang D AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. yangdongling@scdc.sh.cn. FAU - Luo, Chunyan AU - Luo C AD - Division of Child and Adolescent Health, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, 200336, China. luochunyan_ess@163.com. LA - eng GR - GWVI-7/The Sixth Round of Shanghai Public Health Three Year Action Project (2023-2025)/ PT - Journal Article DEP - 20260703 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Air Pollutants) RN - 0 (Hemoglobins) RN - 0 (Particulate Matter) SB - IM MH - Humans MH - *Anemia/epidemiology/chemically induced MH - Female MH - Male MH - *Air Pollutants/adverse effects/analysis MH - China/epidemiology MH - Child MH - *Hemoglobins/analysis MH - *Environmental Exposure/adverse effects/analysis MH - Adolescent MH - Particulate Matter/adverse effects/analysis MH - *Air Pollution/adverse effects/analysis MH - Longitudinal Studies MH - Cohort Studies PMC - PMC13644236 OTO - NOTNLM OT - Adolescent OT - Air pollution OT - Anemia OT - Children OT - Hemoglobin COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical principles of the Declaration of Helsinki. The study was approved by the Ethics Committee of the Shanghai Municipal Center for Disease Control and Prevention (No.2022-13). Participants and their guardians signed informed consent prior to data collection and informed consent was obtained from all included participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/03 06:31 MHDA- 2026/10/07 05:31 PMCR- 2026/07/03 CRDT- 2026/07/03 00:09 PHST- 2025/12/23 00:00 [received] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/10/07 05:31 [medline] PHST- 2026/07/03 06:31 [pubmed] PHST- 2026/07/03 00:09 [entrez] PHST- 2026/07/03 00:00 [pmc-release] AID - 10.1186/s12889-026-27895-z [pii] AID - 27895 [pii] AID - 10.1186/s12889-026-27895-z [doi] PST - epublish SO - BMC Public Health. 2026 Jul 3;26(1):2837. doi: 10.1186/s12889-026-27895-z. PMID- 42393597 OWN - NLM STAT- MEDLINE DCOM- 20261002 LR - 20261007 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jul 3 TI - Pediatric precision sleep network: a study protocol for identifying sleep signatures of mental health risk in peri-adolescents. LID - 10.1186/s12887-026-07253-z [doi] LID - 932 AB - BACKGROUND: Peri-adolescence (ages 10-13) is a sensitive-and clinically critical-developmental window for the emergence of psychiatric symptoms, yet scalable strategies for early risk detection in pediatric primary care (PPC) remain limited. Sleep disturbances are among the most prevalent, predictive, and modifiable indicators of youth mental health, but current pediatric assessments rely heavily on subjective, single-source reports that fail to capture the multidimensional nature of sleep health. The Pediatric Precision Sleep Network (PPSN) is a longitudinal, multi-site study designed to integrate multimodal sleep data with longitudinal clinical outcomes to improve early identification of psychiatric risk during peri-adolescence-a period marked by rapid changes in sleep-circadian biology and vulnerability to psychopathology. METHODS: PPSN will enroll 1,200 youth ages 10-13 across three metropolitan areas (Pittsburgh, Boston, Miami). Over three years, participants will complete multimodal sleep assessments-including self-report, daily sleep logs, actigraphy, ambulatory electroencephalography (EEG), and passive smartphone-based monitoring-administered primarily at home to maximize ecological validity and reduce burden. Psychiatric symptoms and functioning will be assessed biannually via online surveys and electronic health records (EHRs), including structured fields and unstructured notes processed with natural language processing to extract sleep-related information. Scalable, open-source pipelines will automatically derive sleep features. Analyses will: (1) identify multivariable "sleep signatures"-defined as empirically derived patterns of sleep features across modalities-using factor and cluster methods; (2) evaluate their predictive utility for transdiagnostic mental health outcomes using stepwise machine learning approaches; and (3) examine developmental and contextual moderators (e.g., puberty and sociocultural factors). PPSN will also partner with the NIMH Individually Measured Phenotypes to Advance Computational Translation in Mental Health (IMPACT-MH) Data Coordinating Center to standardize procedures, ensure rigorous quality control, and disseminate open-source analytic tools for the broader research community. DISCUSSION: By integrating ecologically valid, longitudinal sleep monitoring with EHR-based and survey outcomes, PPSN aims to identify developmentally sensitive sleep signatures that could be translated into scalable screening tools for PPC. Embedding sleep-informed algorithms into primary care could improve precision and equity of early risk detection and inform future efforts aimed at earlier identification and monitoring of mental health risk in peri-adolescence. CI - (c) 2026. The Author(s). FAU - Baker, Amanda E AU - Baker AE AD - Department of Psychology, Florida International University, 11200 S.W. 8th Street, Miami, FL, 33199, USA. ambaker@fiu.edu. FAU - Cooper, Rebecca E AU - Cooper RE AD - Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Buysse, Daniel J AU - Buysse DJ AD - University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Chien, Alyna T AU - Chien AT AD - Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Gonzalez, Raul Jr AU - Gonzalez R Jr AD - Department of Psychology, Florida International University, 11200 S.W. 8th Street, Miami, FL, 33199, USA. FAU - Levenson, Jessica C AU - Levenson JC AD - University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Miller, Timothy AU - Miller T AD - Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Rivero-Conil, Sara AU - Rivero-Conil S AD - Nicklaus Children's Hospital, Miami, FL, USA. FAU - Seo, David AU - Seo D AD - Nicklaus Children's Hospital, Miami, FL, USA. FAU - Visweswaran, Shyam AU - Visweswaran S AD - University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Wang, Yanshan AU - Wang Y AD - University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Caswell, Allison AU - Caswell A AD - University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Chan, Simey AU - Chan S AD - University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Chiu, Kelly AU - Chiu K AD - Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Corcoran, Mary AU - Corcoran M AD - Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Churchill, Susan AU - Churchill S AD - Nicklaus Children's Hospital, Miami, FL, USA. FAU - Currie, Ronna AU - Currie R AD - University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Duque, Maurice AU - Duque M AD - Nicklaus Children's Hospital, Miami, FL, USA. FAU - Elder, Isabelle AU - Elder I AD - Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Freitag, Josefina AU - Freitag J AD - Nicklaus Children's Hospital, Miami, FL, USA. FAU - Jadhav, Saurabh AU - Jadhav S AD - Department of Psychology, Florida International University, 11200 S.W. 8th Street, Miami, FL, 33199, USA. FAU - Locke, Rebecca AU - Locke R AD - Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Martin, Christopher AU - Martin C AD - Nicklaus Children's Hospital, Miami, FL, USA. FAU - Milla, Maria AU - Milla M AD - Nicklaus Children's Hospital, Miami, FL, USA. FAU - Sahasrabudhe, Rashmi AU - Sahasrabudhe R AD - Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Sathe, Soumya AU - Sathe S AD - Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Shellhause, Karoline AU - Shellhause K AD - University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Sritharan, Aishwarya AU - Sritharan A AD - Department of Psychology, Florida International University, 11200 S.W. 8th Street, Miami, FL, 33199, USA. FAU - Robles, Jerrilyn AU - Robles J AD - Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Werner, Annette AU - Werner A AD - University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Wallace, Meredith J AU - Wallace MJ AD - University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Jalbrzikowski, Maria AU - Jalbrzikowski M AD - Boston Children's Hospital, Harvard Medical School, Boston, MA, USA. FAU - McMakin, Dana L AU - McMakin DL AD - Department of Psychology, Florida International University, 11200 S.W. 8th Street, Miami, FL, 33199, USA. AD - Nicklaus Children's Hospital, Miami, FL, USA. FAU - Soehner, Adriane M AU - Soehner AM AD - University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. LA - eng GR - U01 MH136020/MH/NIMH NIH HHS/United States GR - U01MH136020/MH/NIMH NIH HHS/United States PT - Clinical Trial Protocol PT - Journal Article DEP - 20260703 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Actigraphy MH - Electroencephalography MH - Longitudinal Studies MH - *Mental Disorders/diagnosis MH - Primary Health Care MH - Risk Assessment MH - Self Report MH - *Sleep MH - *Sleep Wake Disorders/diagnosis/complications MH - Multicenter Studies as Topic PMC - PMC13629040 OTO - NOTNLM OT - Sleep health OT - electronic health records OT - mental health OT - pediatric primary care OT - peri-adolescence OT - predictive modeling OT - risk stratification COIS- Declarations. Ethics approval and consent to participate: The Pediatric Precision Sleep Network (PPSN) study protocol has been reviewed and approved by the University of Pittsburgh Institutional Review Board (Pitt IRB; STUDY23110103), as well as the Institutional Review Boards of Boston Children's Hospital/Harvard Medical School and Florida International University/Nicklaus Children's Hospital. Written informed consent is obtained from a parent or legal guardian, and written assent is obtained from youth participants prior to participation. All study procedures are conducted in accordance with the Declaration of Helsinki and relevant institutional and national guidelines. Competing interests: The authors declare that they have no competing interests.J.C.L. receives royalties from American Psychological Association Books.T.M. serves on the scientific advisory board of a healthcare artificial intelligence startup (lavita.ai).MLW is a statistical consultant for Noctem Health and Health Rhythms.These relationships are outside the scope of the submitted work. EDAT- 2026/07/03 06:31 MHDA- 2026/10/02 05:31 PMCR- 2026/07/03 CRDT- 2026/07/03 00:07 PHST- 2026/02/03 00:00 [received] PHST- 2026/06/25 00:00 [accepted] PHST- 2026/10/02 05:31 [medline] PHST- 2026/07/03 06:31 [pubmed] PHST- 2026/07/03 00:07 [entrez] PHST- 2026/07/03 00:00 [pmc-release] AID - 10.1186/s12887-026-07253-z [pii] AID - 7253 [pii] AID - 10.1186/s12887-026-07253-z [doi] PST - epublish SO - BMC Pediatr. 2026 Jul 3;26(1):932. doi: 10.1186/s12887-026-07253-z. PMID- 42393595 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260905 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jul 2 TI - Association of albumin-based inflammatory indices with adverse neonatal outcomes in intrahepatic cholestasis of pregnancy: a retrospective comparative study. LID - 10.1186/s12884-026-09555-7 [doi] LID - 990 AB - OBJECTIVE: To evaluate whether albumin-based inflammatory indices are associated with perinatal and neonatal outcomes in pregnancies complicated by intrahepatic cholestasis of pregnancy (ICP). METHODS: This retrospective comparative study included 277 pregnant women who delivered at a tertiary referral center between January 2020 and December 2025 (ICP, n = 90; controls, n = 187). Albumin-based inflammatory indices were calculated from routine laboratory parameters obtained during the week of delivery. Perinatal and neonatal outcomes were compared between groups. Within the ICP group, associations between inflammatory indices and adverse outcomes were evaluated, and multivariable logistic regression analysis was performed to identify independent predictors within the ICP group of neonatal intensive care unit (NICU) admission. RESULTS: Gestational age at delivery and neonatal birth weight were significantly lower in the ICP group, while rates of preterm birth, low birth weight, and NICU admission were significantly higher compared with controls. Albumin-based inflammatory indices did not differ significantly between groups. Within the ICP group, low birth weight (< 2500 g) was associated with higher NAR (p = 0.031), whereas LAR (p = 0.094) and MAR (p = 0.129) were not statistically significant. NICU admission was associated with higher leukocyte-to-albumin ratio (LAR) (p = 0.036), neutrophil-to-albumin ratio (NAR) (p = 0.032), and monocyte-to-albumin ratio (MAR) (p = 0.017) in univariable analyses. In multivariable logistic regression analysis, higher LAR (OR 1.818, 95% CI 1.026-3.223; p = 0.041) and preterm birth < 37 weeks (OR 6.119, 95% CI 2.145-17.457; p = 0.001) remained independently associated with NICU admission. Exploratory ROC analysis performed within the ICP group demonstrated limited discriminatory performance for all evaluated indices, with modest accuracy observed for LAR (AUC = 0.67) and MAR (AUC = 0.65), whereas other indices, including NPAR (p = 0.455) and CAR (p = 0.065), showed poor and non-significant discriminatory performance. CONCLUSION: Albumin-based inflammatory indices demonstrated limited overall clinical utility in pregnancies complicated by ICP. Among these indices, leukocyte-to-albumin ratio was associated with NICU admission, suggesting a possible association between leukocyte-related inflammatory burden and neonatal outcomes. However, this finding should be interpreted with caution given the limited discriminatory performance of the evaluated indices and the potential for residual confounding. Further prospective studies are needed to validate this observation. CI - (c) 2026. The Author(s). FAU - Cicek, Sevil AU - Cicek S AUID- ORCID: 0000-0001-6147-8102 AD - Department of Obstetrics and Gynecology, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey. svlerslnn@gmail.com. FAU - Kapudere, Bilge AU - Kapudere B AUID- ORCID: 0000-0002-5622-3161 AD - Department of Obstetrics and Gynecology, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey. FAU - Kaya Parspanci, Yasemin Beyza AU - Kaya Parspanci YB AUID- ORCID: 0000-0001-9639-7484 AD - Department of Obstetrics and Gynecology, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey. FAU - Tavukcuoglu, Zehra AU - Tavukcuoglu Z AUID- ORCID: 0000-0001-6951-4761 AD - Department of Obstetrics and Gynecology, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey. FAU - Soyupak, Berkay AU - Soyupak B AUID- ORCID: 0000-0003-0907-8608 AD - Department of Obstetrics and Gynecology, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey. FAU - Eyiceoglu, Merve Amine AU - Eyiceoglu MA AUID- ORCID: 0009-0007-4435-693X AD - Department of Obstetrics and Gynecology, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey. FAU - Kutay Yilmaz, Feyza AU - Kutay Yilmaz F AUID- ORCID: 0000-0002-9575-5291 AD - Artvin Central Community Health Center, Artvin, Turkey. FAU - Ayaz, Reyhan AU - Ayaz R AUID- ORCID: 0000-0001-5261-1792 AD - Department of Obstetrics and Gynecology, Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Istanbul, Turkey. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260702 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - 0 (Serum Albumin) RN - 0 (Biomarkers) RN - Intrahepatic Cholestasis of Pregnancy SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Cholestasis, Intrahepatic/blood/complications MH - Retrospective Studies MH - *Pregnancy Complications/blood MH - Adult MH - Infant, Newborn MH - Pregnancy Outcome MH - Intensive Care Units, Neonatal/statistics & numerical data MH - Premature Birth/epidemiology MH - *Serum Albumin/analysis MH - Gestational Age MH - *Inflammation/blood MH - Biomarkers/blood MH - Infant, Low Birth Weight MH - Birth Weight PMC - PMC13540199 OTO - NOTNLM OT - Albumin OT - Biomarkers OT - Inflammation OT - Intrahepatic cholestasis of pregnancy OT - NICU OT - Neonatal outcomes COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Non-Interventional Clinical Research Ethics Committee of Goztepe Prof. Dr. Suleyman Yalcin City Hospital (Approval No: 2025/0101; Date: 13 August 2025). Due to the retrospective design of the study, the requirement for informed consent was waived. All procedures were conducted in accordance with the Declaration of Helsinki, and patient data were anonymized prior to analysis. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/03 06:31 MHDA- 2026/09/04 05:36 PMCR- 2026/07/02 CRDT- 2026/07/03 00:07 PHST- 2026/02/16 00:00 [received] PHST- 2026/06/18 00:00 [accepted] PHST- 2026/09/04 05:36 [medline] PHST- 2026/07/03 06:31 [pubmed] PHST- 2026/07/03 00:07 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - 10.1186/s12884-026-09555-7 [pii] AID - 9555 [pii] AID - 10.1186/s12884-026-09555-7 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jul 2;26(1):990. doi: 10.1186/s12884-026-09555-7. PMID- 42393133 OWN - NLM STAT- Publisher LR - 20260702 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jul 2 TI - Expression and clinical significance of miR-223 in children with severe pneumonia. LID - 10.1038/s41598-026-59418-6 [doi] AB - Severe pneumonia poses a major life-threatening respiratory disease among children under 5 years old, and conventional laboratory markers lack sufficient specificity for its early identification and severity evaluation, highlighting an urgent need for novel sensitive and specific biomarkers. This study enrolled 107 children diagnosed with severe pneumonia and 107 age- and gender-matched healthy children from January 2024 to June 2025. Quantitative real-time PCR was applied to detect plasma miR-223 expression, and routine hematological, biochemical and coagulation indicators were simultaneously collected for all subjects. Statistical analyses including Mann-Whitney U test, multivariate logistic regression and ROC curve analysis were performed to explore the diagnostic value of miR-223. Plasma miR-223 expression was significantly elevated in children with severe pneumonia compared with healthy controls, and multivariate logistic regression identified miR-223, neutrophil percentage, albumin and fibrinogen as independent risk factors for pediatric severe pneumonia. Single miR-223 yielded an AUC of 0.90 for disease diagnosis, while the combined model of the four indicators achieved an AUC up to 0.99 with superior diagnostic accuracy and sensitivity. Age stratification analysis revealed that miR-223 upregulation existed across all age subgroups of patients, and age exerted no significant interference on its diagnostic performance. Moreover, higher miR-223 levels were correlated with severe complications, PICU admission and longer hospital stays, indicating its potential for disease stratification and short-term prognosis assessment. In summary, plasma miR-223 acts as a reliable molecular biomarker for pediatric severe pneumonia, and its combination with routine inflammatory, nutritional and coagulation markers greatly improves diagnostic efficiency, which provides a promising auxiliary tool for early diagnosis and clinical risk evaluation of children with severe pneumonia. CI - (c) 2026. The Author(s). FAU - Wang, Min AU - Wang M AD - Clinical Laboratory, Children's Hospital Affiliated to Shandong University, 23976 Jing-Shi Road, Jinan, 250022, Shandong Province, PR China. AD - Clinical Laboratory, Jinan Children's Hospital, Jinan, China. FAU - Wang, Juan AU - Wang J AD - Clinical Laboratory, Children's Hospital Affiliated to Shandong University, 23976 Jing-Shi Road, Jinan, 250022, Shandong Province, PR China. AD - Clinical Laboratory, Jinan Children's Hospital, Jinan, China. FAU - Chen, Mengmeng AU - Chen M AD - Clinical Laboratory, Children's Hospital Affiliated to Shandong University, 23976 Jing-Shi Road, Jinan, 250022, Shandong Province, PR China. AD - Clinical Laboratory, Jinan Children's Hospital, Jinan, China. FAU - Hu, Chong AU - Hu C AD - Clinical Laboratory, Children's Hospital Affiliated to Shandong University, 23976 Jing-Shi Road, Jinan, 250022, Shandong Province, PR China. AD - Clinical Laboratory, Jinan Children's Hospital, Jinan, China. FAU - Zhang, Yanzi AU - Zhang Y AD - Clinical Laboratory, Children's Hospital Affiliated to Shandong University, 23976 Jing-Shi Road, Jinan, 250022, Shandong Province, PR China. AD - Clinical Laboratory, Jinan Children's Hospital, Jinan, China. FAU - Zhu, Lingdong AU - Zhu L AUID- ORCID: 0000-0003-4630-9305 AD - Clinical Laboratory, Children's Hospital Affiliated to Shandong University, 23976 Jing-Shi Road, Jinan, 250022, Shandong Province, PR China. zhulingdong_sduch@163.com. AD - Clinical Laboratory, Jinan Children's Hospital, Jinan, China. zhulingdong_sduch@163.com. LA - eng GR - 2023-2-139/Science and Technology Development Program of Jinan Municipal Health Commission/ PT - Journal Article DEP - 20260702 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM OTO - NOTNLM OT - Children OT - MicroRNA-223 OT - Serum OT - Severe pneumonia COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics statement: Ethical approval this study was approved by the Ethical Committee of Children's Hospital affiliated to Shandong University approval number: SDFE-IRB/P-2023031). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent: The requirement to obtain informed consent was waived. EDAT- 2026/07/03 04:10 MHDA- 2026/07/03 04:10 CRDT- 2026/07/02 23:21 PHST- 2026/01/26 00:00 [received] PHST- 2026/06/20 00:00 [accepted] PHST- 2026/07/03 04:10 [medline] PHST- 2026/07/03 04:10 [pubmed] PHST- 2026/07/02 23:21 [entrez] AID - 10.1038/s41598-026-59418-6 [pii] AID - 10.1038/s41598-026-59418-6 [doi] PST - aheadofprint SO - Sci Rep. 2026 Jul 2. doi: 10.1038/s41598-026-59418-6. PMID- 42393014 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261023 IS - 2191-0278 (Electronic) IS - 0334-0139 (Linking) VI - 38 IP - 5 DP - 2026 Oct 1 TI - Cross-cultural adaptation and preliminary validation of the adolescent obesity environmental questionnaire (AOEQ) in LMICs: family, school, and peer contexts. PG - 369-375 LID - 10.1515/ijamh-2026-0037 [doi] AB - OBJECTIVES: Although adolescent obesity is a growing concern in low- and middle-income countries (LMICs), culturally adapted tools to assess environmental risk factors are limited. This study developed and conducted a preliminary validation of the Adolescent Obesity Environmental Questionnaire (AOEQ), with a design intended to be relevant for LMIC contexts. METHODS: Items were generated via literature review, adaptation of existing tools, and focus group discussions. Forward-backward translation and expert panel review ensured content validity. Five experts rated items using Content Validity Index (CVI), and face validity was evaluated with adolescents (FVI). RESULTS: The preliminary AOEQ included 40 items across three domains: family (27), school (6), and peer (7). Expert review showed high content validity (S-CVI/Ave=0.90; I-CVI 0.83-1.00). Face validity confirmed clarity and cultural appropriateness (S-FVI/Ave=0.94). Internal consistency was high (Cronbach's alpha=0.813-0.948). CONCLUSIONS: The AOEQ is a reliable, culturally valid tool for assessing obesogenic environments among Indonesian adolescents, with potential applicability to other adolescents in LMIC settings. CI - (c) 2026 the author(s), published by De Gruyter, Berlin/Boston. FAU - Erlena, Erlena AU - Erlena E AUID- ORCID: 0000-0002-4019-9443 AD - Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia. AD - Faculty of Science, Horizon University, Karawang, Indonesia. FAU - Nurjannah, Intansari AU - Nurjannah I AD - Nursing Science Study Program, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia. FAU - Achadiono, Deddy Nurwachid AU - Achadiono DN AD - Gadjah Mada University Faculty of Medicine, Dr. Sardjito, Yogyakarta, Indonesia. FAU - Wibawa, Tri AU - Wibawa T AUID- ORCID: 0000-0003-0477-4575 AD - Department of Microbiology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia. LA - eng PT - Journal Article PT - Validation Study DEP - 20260706 PL - Germany TA - Int J Adolesc Med Health JT - International journal of adolescent medicine and health JID - 8506960 SB - IM MH - Humans MH - Adolescent MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Female MH - *Pediatric Obesity MH - Developing Countries MH - Indonesia MH - Schools MH - Peer Group MH - Male MH - Family MH - Cross-Cultural Comparison MH - Psychometrics MH - Focus Groups MH - Risk Factors OTO - NOTNLM OT - Indonesia OT - adolescent obesity OT - environmental factors OT - low- and middle-income countries (LMICs) OT - questionnaire validation EDAT- 2026/07/03 04:10 MHDA- 2026/10/23 18:30 CRDT- 2026/07/02 23:02 PHST- 2026/02/27 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/10/23 18:30 [medline] PHST- 2026/07/03 04:10 [pubmed] PHST- 2026/07/02 23:02 [entrez] AID - ijamh-2026-0037 [pii] AID - 10.1515/ijamh-2026-0037 [doi] PST - epublish SO - Int J Adolesc Med Health. 2026 Jul 6;38(5):369-375. doi: 10.1515/ijamh-2026-0037. eCollection 2026 Oct 1. PMID- 42392592 OWN - NLM STAT- MEDLINE DCOM- 20260702 LR - 20260813 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 28 DP - 2026 Jul 2 TI - Development and Validation of an Explainable Machine Learning Model to Assess the Prevalence Probability of Gastrointestinal Heat Retention Syndrome in Children: Cross-Sectional Study. PG - e94775 LID - 10.2196/94775 [doi] LID - e94775 AB - BACKGROUND: Health problems associated with energy metabolism imbalance have received increasing attention. Our team was the first to propose the concept of gastrointestinal heat retention syndrome (GHRS). Triggered by high-calorie diets and excessive energy intake, GHRS is strongly associated with recurrent respiratory infections and other pediatric conditions in children. Existing research on GHRS has primarily focused on risk factor analyses, and no interpretable exploratory self-assessment model for estimating prevalence probability is currently available for routine household use. OBJECTIVE: This study aims to develop and validate an interpretable machine learning model to help caregivers conduct exploratory self-assessments of the probability that children meet the criteria for pediatric GHRS and to provide a practical assessment tool for household use. METHODS: This study conducted a questionnaire survey of kindergarten children in Longgang District, Shenzhen, China. Samples with missing information on GHRS-related symptoms and signs were excluded. Independent correlates were identified using univariate logistic analysis, collinearity testing, Least Absolute Shrinkage and Selection Operator regression, and multivariable logistic regression. After handling missing data and preprocessing, the dataset was randomly divided into training and test sets in an 8:2 ratio. SMOTETomek (Synthetic Minority Oversampling Technique Tomek Links) was included as a conservative resampling step in the training pipeline, and optimal features were selected using a combination of Pearson correlation analysis and recursive feature elimination. In addition, a Random Forest (RF) sensitivity analysis without SMOTETomek was performed, and the minimum required sample size was estimated according to the events per variable (EPV) rule. Seven machine learning models were developed and evaluated in terms of discrimination, calibration, and clinical utility. The SHAP (Shapley Additive Explanations) method was used to interpret the optimal model, which was subsequently deployed online using the Streamlit framework. RESULTS: A total of 120,198 questionnaires were collected, of which 108,447 were deemed valid and included in the analysis. The ratio of GHRS-positive to GHRS-negative cases was nearly balanced. The study identified 59 independent correlates of GHRS, including 10 protective factors and 49 risk factors. After data cleaning, a complete-case dataset of 49,798 participants was obtained, exceeding the minimum sample size requirement of 3747 cases based on the EPV rule. During internal validation, the RF model demonstrated acceptable discriminatory performance, stable calibration, and high net benefit in decision curve analysis, and was therefore selected as the primary analytical model. SHAP analysis identified 5 key predictive features. The resulting online tool collects information through 75 single-choice questions and automatically provides an estimated probability of GHRS together with lifestyle recommendations. CONCLUSIONS: Using cross-sectional data, this study developed and validated an interpretable model that enables caregivers to perform exploratory self-assessments of the probability that children meet the study-specific GHRS scale criteria. As a household self-screening tool, the model helps caregivers estimate this probability based on readily obtainable information and model-generated risk estimates. CI - (c)Senlong Hou, Jiyu Jiang, Xue Li, Mingze Yang, Qilin Chen, Xueyan Ma, Xiaohong Gu. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 02.07.2026. FAU - Hou, Senlong AU - Hou S AUID- ORCID: 0009-0005-1578-261X AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, Beijing, China. FAU - Jiang, Jiyu AU - Jiang J AUID- ORCID: 0009-0006-9994-546X AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, Beijing, China. FAU - Li, Xue AU - Li X AUID- ORCID: 0009-0006-6977-0419 AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, Beijing, China. FAU - Yang, Mingze AU - Yang M AUID- ORCID: 0009-0003-7604-2493 AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, Beijing, China. FAU - Chen, Qilin AU - Chen Q AUID- ORCID: 0009-0003-0501-5949 AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, Beijing, China. FAU - Ma, Xueyan AU - Ma X AUID- ORCID: 0000-0001-8622-7967 AD - Institute of Epidemic Diseases, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. FAU - Gu, Xiaohong AU - Gu X AUID- ORCID: 0000-0001-8361-9455 AD - Institute of Epidemic Diseases, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260702 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 SB - IM MH - Humans MH - *Machine Learning MH - Cross-Sectional Studies MH - Child MH - Prevalence MH - Female MH - *Gastrointestinal Diseases/epidemiology MH - Male MH - Child, Preschool MH - China/epidemiology MH - Surveys and Questionnaires PMC - PMC13376857 OTO - NOTNLM OT - energy metabolism OT - explainability OT - gastrointestinal heat retention syndrome OT - machine learning OT - prevalence probability assessment model COIS- Conflicts of Interest: None declared. EDAT- 2026/07/03 04:10 MHDA- 2026/07/03 04:11 PMCR- 2026/07/02 CRDT- 2026/07/02 19:53 PHST- 2026/03/06 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/03 00:00 [revised] PHST- 2026/07/03 04:11 [medline] PHST- 2026/07/03 04:10 [pubmed] PHST- 2026/07/02 19:53 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - v28i1e94775 [pii] AID - 10.2196/94775 [doi] PST - epublish SO - J Med Internet Res. 2026 Jul 2;28:e94775. doi: 10.2196/94775. PMID- 42392357 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260730 IS - 1872-8057 (Electronic) IS - 0303-7207 (Linking) VI - 620 DP - 2026 Oct TI - Blood-based microRNAs as biomarkers of insulin resistance in childhood obesity: A systematic review and meta-analysis. PG - 112856 LID - S0303-7207(26)00133-4 [pii] LID - 10.1016/j.mce.2026.112856 [doi] AB - Childhood obesity is closely linked to insulin resistance, but affected children are metabolically heterogeneous. Blood-based microRNAs (miRNAs) have emerged as potential minimally invasive biomarkers of early metabolic dysfunction. A systematic search of PubMed, Embase, Web of Science, and Scopus was conducted from database inception to April 1, 2026. Eligible studies included children or adolescents with obesity that evaluated blood-based miRNAs, including serum, plasma, or peripheral blood mononuclear cell-derived miRNAs, in relation to IR. Narrative synthesis was the primary approach. Study quality was assessed using the Newcastle-Ottawa Scale, and exploratory quantitative synthesis was performed only for comparable miRNA-outcome pairs with extractable correlation data. Twenty studies met the inclusion criteria; 7 were rated as low risk of bias, 11 as moderate risk, and 2 as high risk. Most studies had cross-sectional or case-control designs, and substantial heterogeneity was present in study populations, biological sample source, insulin resistance definitions, miRNA methods, and outcome reporting. Across the included studies, miR-122 was the most consistent candidate, showing recurrent up-regulation in adverse metabolic phenotypes and positive associations with HOMA-IR (r = 0.53; 95%CI, 0.35-0.67) or related IR markers (r = 0.60; 95%CI, 0.47-0.70). miR-29a also showed relatively consistent positive associations (r = 0.67; 95%CI, 0.59-0.73), particularly in cohorts with more severe metabolic impairment. Other candidates, including miR-146a, miR-34a, miR-191-3p, miR-30d-5p, and miR-221-3p, showed relevant but less consistent findings. Blood-based miRNAs are associated with IR in childhood obesity, with miR-122 emerging as the strongest and most recurrent candidate and miR-29a as another promising marker. However, the evidence remains heterogeneous and insufficient for clinical application. Larger, standardized, and longitudinal studies are needed to validate the most recurrent candidates and define their role in early risk stratification. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Wang, Lin AU - Wang L AD - Department of Acupuncture, Qingdao Traditional Chinese Medicine Hospital, Qingdao Hiser Hospital Affiliated of Qingdao University, Qingdao, 266000, China. FAU - Liu, Zhaofen AU - Liu Z AD - Department of Outpatient, Weifang People's Hospital, Weifang, 261041, China. Electronic address: lzf13906368234@outlook.com. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260702 PL - Ireland TA - Mol Cell Endocrinol JT - Molecular and cellular endocrinology JID - 7500844 RN - 0 (MicroRNAs) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Insulin Resistance/genetics MH - *MicroRNAs/blood/genetics MH - *Biomarkers/blood MH - *Pediatric Obesity/blood/genetics MH - Child OTO - NOTNLM OT - Childhood obesity OT - HOMA-IR OT - Insulin resistance OT - miR-122 OT - miR-29a OT - microRNA COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/03 04:10 MHDA- 2026/07/09 04:10 CRDT- 2026/07/02 19:30 PHST- 2026/05/08 00:00 [received] PHST- 2026/06/24 00:00 [revised] PHST- 2026/07/02 00:00 [accepted] PHST- 2026/07/09 04:10 [medline] PHST- 2026/07/03 04:10 [pubmed] PHST- 2026/07/02 19:30 [entrez] AID - S0303-7207(26)00133-4 [pii] AID - 10.1016/j.mce.2026.112856 [doi] PST - ppublish SO - Mol Cell Endocrinol. 2026 Oct;620:112856. doi: 10.1016/j.mce.2026.112856. Epub 2026 Jul 2. PMID- 42392350 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260904 IS - 1879-176X (Electronic) IS - 0300-5712 (Linking) VI - 175 DP - 2026 Dec TI - Accuracy of 2D facial profile photographs under routine clinical conditions compared with 3D imaging. PG - 106878 LID - S0300-5712(26)00548-8 [pii] LID - 10.1016/j.jdent.2026.106878 [doi] AB - OBJECTIVE: To assess the accuracy of facial soft-tissue profile lines derived from two-dimensional (2D) photographs acquired under routine clinical conditions, using three-dimensional (3D) facial photographs as the reference standard. METHODS: This study analysed pre-existing 2D and 3D facial photographs of 160 orthodontic patients. True facial profile lines were generated from 3D photographs using an automated midsagittal plane based on best-fit superimposition of mirrored surface models. Corresponding profile lines were traced on 2D photographs. Fixed landmarks and sliding semilandmarks were placed on predefined profile curves, and configurations were analysed using geometric morphometrics. Pairwise Procrustes superimposition was performed, and Procrustes distances quantified discrepancies between 2D- and 3D-derived profiles. The effects of age and sex were evaluated. RESULTS: Significant differences were found between 2D-derived and 3D reference profiles (P < 0.001). The median discrepancy was 0.75 mm (IQR 0.79 mm; range 0.01-9.36 mm), with the largest differences in the lip region. Although mean discrepancies were small, variability at the individual level was considerable. Differences exceeding +/-1 mm and +/-2 mm occurred in 35.2% and 8.2% of measurements, respectively. Errors were greater in males and younger subjects, with no significant interaction. CONCLUSIONS: 2D photographs show statistically significant and clinically relevant discrepancies compared with 3D-based profiles. While average errors are small, individual variability should be considered when precise assessment is required. CLINICAL SIGNIFICANCE: Routine 2D facial photographs may be insufficient for accurate individual-level soft-tissue profile assessment. Clinicians should be cautious when using them for diagnosis or treatment planning where precision is critical. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Opacic, Jasmina AU - Opacic J AD - Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Switzerland. FAU - Kanavakis, Georgios AU - Kanavakis G AD - Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, GR-11527 Athens, Greece. FAU - Halazonetis, Demetrios AU - Halazonetis D AD - Department of Orthodontics, School of Dentistry, National and Kapodistrian University of Athens, GR-11527 Athens, Greece. FAU - Gkantidis, Nikolaos AU - Gkantidis N AD - Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Switzerland. Electronic address: nikolaos.gkantidis@unibe.ch. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260702 PL - England TA - J Dent JT - Journal of dentistry JID - 0354422 SB - IM MH - Humans MH - *Imaging, Three-Dimensional/statistics & numerical data/methods/standards MH - *Face/anatomy & histology MH - Male MH - Female MH - Adolescent MH - *Photography/statistics & numerical data/methods/standards MH - Image Processing, Computer-Assisted/statistics & numerical data/methods MH - Anatomic Landmarks/anatomy & histology MH - *Cephalometry/statistics & numerical data/methods MH - Young Adult MH - Age Factors MH - Adult MH - Sex Factors MH - Lip/anatomy & histology MH - Child MH - Reproducibility of Results OTO - NOTNLM OT - Data accuracy OT - Face OT - Geometric morphometrics OT - Midsagittal plane OT - Photography OT - Three-dimensional imaging OT - Two-dimensional imaging COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: D. Halazonetis owns stock in dHAL Software, the company that markets Viewbox 4. Demetrios Halazonetis was not involved in data generation and analysis, and thus, could not affect the study outcomes. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/03 04:10 MHDA- 2026/09/04 23:36 CRDT- 2026/07/02 19:30 PHST- 2026/03/28 00:00 [received] PHST- 2026/06/22 00:00 [revised] PHST- 2026/07/01 00:00 [accepted] PHST- 2026/09/04 23:36 [medline] PHST- 2026/07/03 04:10 [pubmed] PHST- 2026/07/02 19:30 [entrez] AID - S0300-5712(26)00548-8 [pii] AID - 10.1016/j.jdent.2026.106878 [doi] PST - ppublish SO - J Dent. 2026 Dec;175:106878. doi: 10.1016/j.jdent.2026.106878. Epub 2026 Jul 2. PMID- 42391866 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 1873-4235 (Electronic) IS - 0956-5663 (Linking) VI - 311 DP - 2026 Nov 1 TI - Four-in-one multifunctional CoCu-NC@AuPt nanozyme integrated M13 phage-displayed nanobody based multimodal lateral flow immunoassay for bovine lactoferrin detection. PG - 118970 LID - S0956-5663(26)00602-0 [pii] LID - 10.1016/j.bios.2026.118970 [doi] AB - Bovine lactoferrin (LF) is widely used as a nutritional additive in infant formula and functional foods, but is also a milk allergen. Therefore, rapid and sensitive detection of LF is crucial for ensuring food quality and protecting public health. Here, we report a multimodal lateral flow immunoassay (LFIA) for LF detection that integrates an M13 phage-displayed nanobody (M13-Nb) with a "four-in-one" multifunctional nanozyme, namely an AuPt nanoparticle-loaded CoCu-embedded nitrogen-doped carbon nanocomposite (CoCu-NC@AuPt). The specific M13-Nb against LF was isolated from a naive nanobody library. The synthesized CoCu-NC@AuPt exhibits magnetic, colorimetric, peroxidase-mimetic, and photothermal properties, enabling magnetic enrichment and triple-mode sensing (colorimetric, catalytic colorimetric, and photothermal modes). The proposed assay achieved detection limits of 98 pg/mL, 8.49 pg/mL, and 37 pg/mL for the three detection modes, respectively. Practical applicability was verified in pasteurized milk, UHT milk, and yogurt samples, with recoveries of 86.2%-112.5% and coefficients of variation below 15%. This work provides a reliable and sensitive platform for on-site LF detection and demonstrates the potential of combining CoCu-NC@AuPt nanozyme with phage-displayed nanobodies to improve point-of-care testing performance. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Liu, Wanwan AU - Liu W AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China. FAU - Dong, Wenyi AU - Dong W AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China. FAU - Qiu, Yulou AU - Qiu Y AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China; Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, 310018, China. Electronic address: yulou@cjlu.edu.cn. FAU - Zhu, Yutao AU - Zhu Y AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China. FAU - Qiu, Jia AU - Qiu J AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China. FAU - Wang, Jianping AU - Wang J AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China; Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, 310018, China. FAU - Qin, Weiwei AU - Qin W AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China; Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, 310018, China. FAU - Shentu, Xuping AU - Shentu X AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China; Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, 310018, China. Electronic address: stxp@cjlu.edu.cn. FAU - Ye, Zihong AU - Ye Z AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China; Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, 310018, China. FAU - Yu, Xiaoping AU - Yu X AD - Key Laboratory of Microbiological Metrology, Measurement & Bio-product Quality Security, State Administration for Market Regulation, China Jiliang University, Hangzhou, 310018, China; Zhejiang Provincial Key Laboratory of Biometrology and Inspection & Quarantine, College of Life Sciences, China Jiliang University, Hangzhou, 310018, China. Electronic address: yxp@cjlu.edu.cn. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20260630 PL - England TA - Biosens Bioelectron JT - Biosensors & bioelectronics JID - 9001289 RN - EC 3.4.21.- (Lactoferrin) RN - 0 (Single-Domain Antibodies) RN - 7440-44-0 (Carbon) SB - IM MH - *Lactoferrin/analysis/isolation & purification MH - Animals MH - Cattle MH - Immunoassay/methods MH - *Milk/chemistry MH - *Biosensing Techniques/methods MH - Limit of Detection MH - Bacteriophage M13/chemistry MH - *Single-Domain Antibodies/chemistry MH - Nanocomposites/chemistry/ultrastructure MH - Colorimetry MH - Carbon/chemistry MH - Food Analysis/methods MH - Metal Nanoparticles/chemistry OTO - NOTNLM OT - Lactoferrin OT - Lateral flow immunoassay OT - Multimodal detection OT - Nanobody OT - Nanozyme COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/03 04:10 MHDA- 2026/07/12 00:55 CRDT- 2026/07/02 18:08 PHST- 2026/04/14 00:00 [received] PHST- 2026/06/10 00:00 [revised] PHST- 2026/06/27 00:00 [accepted] PHST- 2026/07/12 00:55 [medline] PHST- 2026/07/03 04:10 [pubmed] PHST- 2026/07/02 18:08 [entrez] AID - S0956-5663(26)00602-0 [pii] AID - 10.1016/j.bios.2026.118970 [doi] PST - ppublish SO - Biosens Bioelectron. 2026 Nov 1;311:118970. doi: 10.1016/j.bios.2026.118970. Epub 2026 Jun 30. PMID- 42390538 OWN - NLM STAT- MEDLINE DCOM- 20260702 LR - 20261010 IS - 1279-8517 (Electronic) IS - 0930-1038 (Linking) VI - 48 IP - 1 DP - 2026 Jul 2 TI - MRI-based normative orbital anthropometric measurements in pediatric populations: age-related variations and clinical implications. LID - 169 [pii] LID - 10.1007/s00276-026-03940-9 [doi] AB - PURPOSE: Accurate anthropometric data of the pediatric orbit is critical for diagnosing and managing various pediatric orbital pathologies and for planning surgical and reconstructive interventions. The purpose of this study was to establish MRI-based normative anthropometric data for pediatric orbital structures, analyze age-related variations, and evaluate interobserver reliability among expert neuroradiologists. METHODS: This retrospective study included 64 healthy pediatric patients (32 males, 32 females; age range, 1-17 years) who underwent MRI scans for indications unrelated to orbital pathology. Patients were categorized into three age groups: pre-school (3-6 years), school-age (7-12 years), and adolescent (13-17 years). MRI scans acquired at 1.5 Tesla and 3 Tesla were independently evaluated by three neuroradiologists to measure orbital anthropometric parameters, including extraocular muscle dimensions, orbital breadth, orbital height, interzygomatic line length, intercanthal distance, optic nerve sheath width, and optic nerve angle. Statistical analyses included Spearman's correlation, Kruskal-Wallis tests, Mann-Whitney U tests, and intraclass correlation coefficients (ICC) to assess interobserver reliability. RESULTS: Significant positive correlations were identified between patient age and orbital parameters, particularly the interzygomatic line length (Spearman's r = 0.772, p < 0.001). Orbital breadth (right: r = 0.674; left: r = 0.703) and orbital height (right: r = 0.608; left: r = 0.644) also significantly increased with advancing age (all p < 0.001). Interobserver reliability demonstrated excellent reproducibility, with ICC values notably high for orbital breadth (ICC = 0.92, 95% CI: 0.89-0.95) and orbital height (ICC = 0.90, 95% CI: 0.87-0.93). CONCLUSION: MRI-based normative anthropometric measurements provide precise and reliable reference values for pediatric orbital anatomy. These measurements reveal significant age-related developmental trends, enhancing diagnostic accuracy, clinical management, and surgical planning in pediatric orbital conditions. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag France SAS, part of Springer Nature. FAU - Gulsever, Cafer Ikbal AU - Gulsever CI AD - Department of Neurosurgery, Hakkari State Hospital, Hakkari, Turkey. cafer.gulsever@gmail.com. FAU - Ates, Alaaddin AU - Ates A AD - Department of Radiology, Hakkari State Hospital, Hakkari, Turkey. FAU - Karli, Elif Hazal AU - Karli EH AD - Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. FAU - Karapinar, Edanur AU - Karapinar E AD - Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. FAU - Bayramoglu, Zuhal AU - Bayramoglu Z AD - Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. FAU - Cakir, Mehmet Semih AU - Cakir MS AD - Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. FAU - Durak, Gorkem AU - Durak G AD - Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. FAU - Sencer, Serra AU - Sencer S AD - Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. FAU - Barburoglu, Mehmet AU - Barburoglu M AD - Department of Radiology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20260702 PL - Germany TA - Surg Radiol Anat JT - Surgical and radiologic anatomy : SRA JID - 8608029 SB - IM MH - Humans MH - Child MH - Female MH - Child, Preschool MH - *Magnetic Resonance Imaging MH - Male MH - Adolescent MH - *Orbit/anatomy & histology/diagnostic imaging MH - Retrospective Studies MH - Infant MH - Reproducibility of Results MH - Reference Values MH - Anthropometry/methods MH - Age Factors MH - Observer Variation MH - Oculomotor Muscles/anatomy & histology/diagnostic imaging OTO - NOTNLM OT - Magnetic resonance imaging (MRI) OT - Normative data OT - Orbital anthropometry OT - Orbital measurements OT - Pediatric orbit COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval: This study was approved by the Ethics Committee of Istanbul University, Istanbul Faculty of Medicine (Approval No. 12.05.2024-2476179). All procedures were performed in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments. Consent to participate: Informed consent was obtained from all individual participants included in this study. For pediatric patients, written consent was provided by a parent or legal guardian prior to participation. Consent to publication: All authors have read and approved the final manuscript and consent to its publication. EDAT- 2026/07/02 12:33 MHDA- 2026/07/02 12:34 CRDT- 2026/07/02 11:03 PHST- 2025/09/24 00:00 [received] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/07/02 12:34 [medline] PHST- 2026/07/02 12:33 [pubmed] PHST- 2026/07/02 11:03 [entrez] AID - 10.1007/s00276-026-03940-9 [pii] AID - 10.1007/s00276-026-03940-9 [doi] PST - epublish SO - Surg Radiol Anat. 2026 Jul 2;48(1):169. doi: 10.1007/s00276-026-03940-9. PMID- 42389673 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260702 LR - 20260813 IS - 2590-1133 (Electronic) IS - 2590-1133 (Linking) VI - 12 DP - 2026 Dec TI - Measuring neurodevelopment in iron-deficient children in sub-Saharan Africa: A systematic review of evidence and gaps. PG - 100274 LID - 10.1016/j.gloepi.2026.100274 [doi] LID - 100274 AB - Anemia and iron-deficiency anemia are prevalent in sub-Saharan Africa (SSA) and linked to impaired brain and developmental outcomes. Progress in understanding these effects is constrained by inconsistent developmental measurement and minimal neuroimaging. This review evaluated how brain growth, cognition, and developmental status have been measured among children under five exposed to anemia, iron deficiency (ID), or iron-deficiency anemia (IDA) in SSA, to assess the availability, reliability, and limitations of neurodevelopmental measurement approaches and implications for comparability and interpretation. A systematic review (PROSPERO CRD42024529208) was conducted following PRISMA guidelines. Six databases were searched for English-language studies published between Jan 1, 2013, and Apr 30, 2024, aligning with the WHO 2013-2025 global nutrition targets. Eligible studies included children aged 0-5 years in SSA exposed to anemia, ID, or IDA and reporting neurodevelopmental outcomes. Findings were synthesized narratively to characterize measurement heterogeneity, reliability reporting, and neuroimaging use. Evidence quality was appraised narratively based on study design and reporting completeness. Of 2254 records screened, 19 studies from nine countries met inclusion criteria. Fourteen studies assessed developmental status, 13 assessed cognition, and only three measured brain outcomes using MRI or near-infrared spectroscopy. Substantial heterogeneity in measurement constructs, assessment tools, cultural adaptations, scoring approaches, and timing of assessment precluded quantitative meta-analysis. Reliability reporting was limited, with psychometric indices reported in seven of 14 developmental studies and nine of 13 cognitive studies. Only three studies incorporated direct measures of brain structure or function, limiting opportunities to relate behavioral outcomes to brain development. Marked measurement heterogeneity, sparse reliability reporting, and the near-absence of neuroimaging constrain epidemiological inference, cross-study comparability, and mechanistic understanding of neurodevelopmental outcomes associated with anemia and ID in SSA. Strengthening culturally grounded assessment frameworks and more equitable, accessible approaches to objective brain measurement are priorities for improving measurement precision and understanding iron-related developmental outcomes. CI - (c) 2026 The Authors. Published by Elsevier Inc. FAU - Vokhiwa, Maclean AU - Vokhiwa M AD - Kamuzu University of Health Sciences (KUHeS), Blantyre, Malawi. AD - Training and Research Unit of Excellence (TRUE), Zomba, Malawi. FAU - Pitchford, Nicola AU - Pitchford N AD - International Centre for EdTech Impact, Stavanger, Norway. FAU - Cohee, Lauren AU - Cohee L AD - Pediatrics and Child Health, Liverpool School of Tropical Medicine, Liverpool, UK. FAU - Phiri, Kamija S AU - Phiri KS AD - Training and Research Unit of Excellence (TRUE), Zomba, Malawi. FAU - Umar, Eric AU - Umar E AD - Kamuzu University of Health Sciences (KUHeS), Blantyre, Malawi. LA - eng PT - Journal Article DEP - 20260619 PL - United States TA - Glob Epidemiol JT - Global epidemiology JID - 101759263 PMC - PMC13320419 OTO - NOTNLM OT - Africa OT - Anemia OT - Iron deficiency OT - Measurement equity OT - Neurodevelopment OT - Neuroimaging COIS- We declare no competing interests. EDAT- 2026/07/02 06:37 MHDA- 2026/07/02 06:38 PMCR- 2026/06/19 CRDT- 2026/07/02 05:09 PHST- 2026/01/14 00:00 [received] PHST- 2026/06/02 00:00 [revised] PHST- 2026/06/18 00:00 [accepted] PHST- 2026/07/02 06:38 [medline] PHST- 2026/07/02 06:37 [pubmed] PHST- 2026/07/02 05:09 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - S2590-1133(26)00033-7 [pii] AID - 100274 [pii] AID - 10.1016/j.gloepi.2026.100274 [doi] PST - epublish SO - Glob Epidemiol. 2026 Jun 19;12:100274. doi: 10.1016/j.gloepi.2026.100274. eCollection 2026 Dec. PMID- 42389040 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260702 LR - 20260813 IS - 2813-4540 (Electronic) IS - 2813-4540 (Linking) VI - 5 DP - 2026 TI - Monitoring physical health in child and adolescent mental health inpatient care: findings from the Y-Health longitudinal feasibility study. PG - 1731769 LID - 10.3389/frcha.2026.1731769 [doi] LID - 1731769 AB - BACKGROUND: Young people with serious mental illness (SMI) face significant physical health inequalities, including increased risk of obesity, diabetes, and other preventable conditions, contributing to a 15-20-year reduction in life expectancy. Those in CAMHS inpatient care are particularly vulnerable due to high levels of psychological distress, psychotropic medication, obesogenic environments and high levels of adverse health behaviours. However, research in this setting is limited. This study aimed to assess the feasibility of monitoring physical health in CAMHS inpatient services, changes to physical and mental health over 6-months and explore young people's experiences of health care. METHODS: A longitudinal feasibility study with a separate qualitative component was conducted across three CAMHS inpatient units, assessing physical and mental health at admission, 3-months and 6-months. Feasibility indicators and clinical outcomes including weight, cardiometabolic markers, lifestyle behaviours and wellbeing were collected through self-report, clinical records and physical health checks. A nested qualitative sub-study was conducted to explore participant experiences of physical health care in CAMHS. RESULTS: Twenty-seven participants were recruited across three CAMHS inpatient units, with 93% (n = 25) retained at 6-month follow-up. Completion of assessments was high at baseline but declined post-discharge. At baseline 37% individuals were overweight or obese, which increased to 50% overweight or obese at follow-up. Metabolic conditions were frequently observed across all timepoints. Physical activity remained low, and diet quality was poor. Mental health and functioning appeared to improve, with reductions in HONOSCA scores suggesting improvements to overall health. CONCLUSION: This study provides the first longitudinal feasibility evidence on monitoring physical health among young people in CAMHS inpatient care, demonstrating high acceptability during admission and identifying substantial challenges with post-discharge monitoring. While descriptive trends indicated a high prevalence of physical health risk factors, the study was not powered to detect meaningful change. These findings highlight the need for integrated, developmentally appropriate models of physical health monitoring across inpatient and community services. CI - (c) 2026 Carney, Imran, Law, Lovell, Ravindrarajah, Fenton, Green, Macafee, Erunkulu and Parker. FAU - Carney, Rebekah AU - Carney R AD - Youth Mental Health Research Unit, Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom. AD - Division of Psychology and Mental Health, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom. FAU - Imran, Shermin AU - Imran S AD - Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom. FAU - Law, Heather AU - Law H AD - Youth Mental Health Research Unit, Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom. FAU - Lovell, Karina AU - Lovell K AD - Division of Nursing, Midwifery and Social Work, University of Manchester, Manchester, United Kingdom. FAU - Ravindrarajah, Rathi AU - Ravindrarajah R AD - Division of Nursing, Midwifery and Social Work, University of Manchester, Manchester, United Kingdom. FAU - Fenton, Clare AU - Fenton C AD - Leeds and York Partnership Trust, Leeds, United Kingdom. FAU - Green, Nicola AU - Green N AD - Navigo Child and Adolescent Mental Health Service (Young Minds Matter), Northeast Lincolnshire, United Kingdom. FAU - Macafee, Gillian AU - Macafee G AD - Youth Mental Health Research Unit, Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom. FAU - Erunkulu, Olorunleke AU - Erunkulu O AD - Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom. FAU - Parker, Sophie AU - Parker S AD - Youth Mental Health Research Unit, Greater Manchester Mental Health NHS Foundation Trust, Manchester, United Kingdom. AD - Division of Psychology and Mental Health, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom. LA - eng PT - Journal Article DEP - 20260617 PL - Switzerland TA - Front Child Adolesc Psychiatry JT - Frontiers in child and adolescent psychiatry JID - 9918627188506676 PMC - PMC13319068 OTO - NOTNLM OT - adolescent OT - health behaviour OT - longitudinal studies OT - mental health services OT - metabolic health OT - physical health COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author RC declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/07/02 10:10 MHDA- 2026/07/02 10:11 PMCR- 2026/06/17 CRDT- 2026/07/02 05:02 PHST- 2025/10/29 00:00 [received] PHST- 2026/05/08 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/07/02 10:11 [medline] PHST- 2026/07/02 10:10 [pubmed] PHST- 2026/07/02 05:02 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - 10.3389/frcha.2026.1731769 [doi] PST - epublish SO - Front Child Adolesc Psychiatry. 2026 Jun 17;5:1731769. doi: 10.3389/frcha.2026.1731769. eCollection 2026. PMID- 42388159 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260922 LR - 20260924 IS - 2287-8572 (Print) IS - 2287-8580 (Electronic) IS - 2287-8572 (Linking) VI - 69 IP - 5 DP - 2026 Sep TI - Predictive value of glycated hemoglobin levels for large for gestational age infants in women with pregestational diabetes according to body mass index. PG - 305-316 LID - 10.5468/ogs.26123 [doi] AB - OBJECTIVE: To evaluate whether pre-pregnancy body mass index (BMI) modifies the predictive ability of glycosylated hemoglobin (HbA1c) for large for gestational age (LGA) infants in women with pregestational diabetes. METHODS: This multicenter retrospective cohort study included 402 women with pregestational diabetes from 17 University Hospitals in South Korea. Pregestational diabetes included early-diagnosed gestational diabetes, type 1 diabetes, and type 2 diabetes. Participants were categorized by pre-pregnancy BMI (<25 vs. >/=25 kg/m2). The primary outcome was LGA birth. Logistic regression was used to assess the association between trimester-specific HbA1c levels and LGA in each BMI group. Receiver operating characteristic (ROC) curve analysis evaluated predictive performance. RESULTS: Among 402 women, 183 (45.5%) had a BMI <25 kg/m2 and 219 (54.5%) had a BMI >/=25 kg/m2. In the BMI <25 kg/m2 group, higher HbA1c levels in all trimesters were significantly associated with an increased risk of LGA, with the strongest association in the third trimester (odds ratio [OR], 2.28; 95% confidence interval [CI], 1.46-3.58). In women with BMI >/=25 kg/m2, only third-trimester HbA1c was significantly associated with LGA (OR, 1.455; 95% CI, 1.069-1.981). ROC analysis showed moderate discrimination for LGA prediction in women with BMI <25 kg/m2 (area under the curve [AUC], 0.70-0.82), but poor discrimination in those with BMI >/=25 kg/m2 (all AUCs /=25 kg/m2. FAU - Lee, Sujin AU - Lee S AD - Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. FAU - Park, Suyeon AU - Park S AD - Department of Obstetrics and Gynecology, Inha University Hospital, School of Medicine, Inha University, Incheon, Korea. FAU - Sung, Ji-Hee AU - Sung JH AD - Department of Obstetrics and Gynecology, Samsung Medical Center, School of Medicine, Sungkyunkwan University, Seoul, Korea. FAU - Seol, Hyun-Joo AU - Seol HJ AD - Department of Obstetrics and Gynecology, Korea University Guro Hospital, College of Medicine, Korea University, Seoul, Korea. FAU - Lee, JoonHo AU - Lee J AD - Department of Obstetrics and Gynecology, Yonsei University College of Medicine, Seoul, Korea. FAU - Kim, Seung-Chul AU - Kim SC AD - Department of Obstetrics and Gynecology, Pusan National University School of Medicine, Busan, Korea. FAU - Choi, Sae-Kyoung AU - Choi SK AD - Department of Obstetrics and Gynecology, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. FAU - Lee, Seung Mi AU - Lee SM AD - Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Korea. FAU - Lee, Se Jin AU - Lee SJ AD - Department of Obstetrics and Gynecology, Kangwon National University Hospital, College of Medicine, Kangwon National University, Chuncheon, Korea. FAU - Hwang, Han-Sung AU - Hwang HS AD - Department of Obstetrics and Gynecology, Konkuk University Hospital, School of Medicine, Konkuk University, Seoul, Korea. FAU - Lee, Gi-Su AU - Lee GS AD - Department of Obstetrics and Gynecology, Keimyung University Dongsan Hospital, School of Medicine, Keimyung University, Daegu, Korea. FAU - Park, Hyun-Soo AU - Park HS AD - Department of Obstetrics and Gynecology, Dongguk University Ilsan Hospital, Goyang, Korea. AD - Family Medicine Residency, Providence St. Joseph Eureka Hospital, College of Medicine, Eureka, CA, USA. FAU - Lee, Soo-Jeong AU - Lee SJ AD - Department of Obstetrics and Gynecology, Ulsan University Hospital, College of Medicine, University of Ulsan, Ulsan, Korea. FAU - Cho, Geum Joon AU - Cho GJ AD - Department of Obstetrics and Gynecology, Korea University Guro Hospital, College of Medicine, Korea University, Seoul, Korea. FAU - Hong, Subeen AU - Hong S AD - Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. unihsy@catholic.ac.kr. FAU - Ko, Hyun Sun AU - Ko HS AD - Department of Obstetrics and Gynecology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea. mongkoko@catholic.ac.kr. LA - eng GR - Patient-Centered Clinical Research Coordinating Center/ GR - RS-2023-KH137595/Ministry of Health and Welfare/ GR - Catholic Medical Center Research Foundation/ PT - Journal Article DEP - 20260701 PL - Korea (South) TA - Obstet Gynecol Sci JT - Obstetrics & gynecology science JID - 101602614 PMC - PMC13597153 OTO - NOTNLM OT - Body mass index OT - Diabetes mellitus OT - Infant OT - Large for gestational age OT - Pregnancy COIS- Conflict of interest The authors have no conflicts of interest relevant to this study to disclose. EDAT- 2026/07/02 10:10 MHDA- 2026/07/02 10:11 PMCR- 2026/09/01 CRDT- 2026/07/02 04:39 PHST- 2026/04/16 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/07/02 10:11 [medline] PHST- 2026/07/02 10:10 [pubmed] PHST- 2026/07/02 04:39 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - ogs.26123 [pii] AID - ogs-26123 [pii] AID - 10.5468/ogs.26123 [doi] PST - ppublish SO - Obstet Gynecol Sci. 2026 Sep;69(5):305-316. doi: 10.5468/ogs.26123. Epub 2026 Jul 1. PMID- 42388046 OWN - NLM STAT- MEDLINE DCOM- 20260702 LR - 20260813 IS - 2314-6753 (Electronic) IS - 2314-6745 (Print) VI - 2026 IP - 1 DP - 2026 TI - Associations Between a Surrogate Index of Insulin Resistance and Hyperuricemia in Young and Middle-Aged Patients With Type 2 Diabetes Mellitus. PG - e6682372 LID - 10.1155/jdr/6682372 [doi] LID - 6682372 AB - BACKGROUND: This study is aimed at examining the associations between insulin resistance (IR) surrogate indices, including TyG, TyG-BMI, TG/HDL-C, and METS-IR, and hyperuricemia (HUA) in young and middle-aged patients with Type 2 diabetes mellitus (T2DM). METHODS: A total of 1005 patients with T2DM were included in this cross-sectional study. Participants were classified into HUA and nonhyperuricemia (NHUA) groups according to serum uric acid concentrations and further stratified by age into young (18-44 years) and middle-aged (45-59 years) subgroups. Multivariable logistic regression analyses were performed to assess the associations between IR surrogate indices and HUA. Receiver operating characteristic (ROC) curve analysis was conducted to evaluate the discriminatory ability of these indices for HUA across sex- and age-specific subgroups. RESULTS: All IR surrogate indices were significantly higher in the HUA group than in the NHUA group. TyG and TG/HDL-C showed stable associations with HUA across the regression models, while the association for TyG-BMI was attenuated after additional adjustment when modeled continuously, although individuals in the highest quartile remained associated with higher odds of HUA. METS-IR was associated with HUA only in unadjusted models. Age-stratified analyses showed that none of the IR surrogate indices remained significantly associated with HUA after multivariable adjustment in younger patients, whereas TyG and TG/HDL-C remained associated with higher odds of HUA in middle-aged patients. ROC analyses indicated limited to moderate discriminatory performance (AUC < 0.75). TyG-BMI showed the highest AUC in younger patients (AUC = 0.715), while TG/HDL-C demonstrated relatively higher specificity in middle-aged patients. Sex-stratified analyses showed slightly higher AUC values in males than in females, although overall discrimination remained modest. CONCLUSION: IR surrogate indices showed varying associations with HUA in young and middle-aged patients with Type 2 diabetes. TyG and TG/HDL-C showed relatively stable associations with HUA across the regression models, whereas the associations for TyG-BMI and METS-IR were attenuated after additional adjustment. Overall, these indices demonstrated limited discriminatory performance and are not suitable as standalone diagnostic tools but may serve as adjunctive markers for preliminary risk stratification. CI - Copyright (c) 2026 Hongping Wang et al. Journal of Diabetes Research published by John Wiley & Sons Ltd. FAU - Wang, Hongping AU - Wang H AD - Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn. FAU - Yang, Yunyi AU - Yang Y AUID- ORCID: 0000-0001-8280-2901 AD - Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn. FAU - Gao, Jie AU - Gao J AUID- ORCID: 0000-0003-3330-2219 AD - Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn. FAU - Lei, Tao AU - Lei T AUID- ORCID: 0000-0002-5766-5113 AD - Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn. FAU - Xia, Juan AU - Xia J AD - Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn. FAU - Zhang, Cuiping AU - Zhang C AD - Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn. FAU - Shen, Tian AU - Shen T AD - Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn. FAU - Lu, Jun AU - Lu J AUID- ORCID: 0000-0002-8884-6291 AD - Department of Endocrinology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn. FAU - Liu, Zongjun AU - Liu Z AUID- ORCID: 0000-0003-4993-2354 AD - Department of Cardiology, Putuo Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China, shutcm.edu.cn. LA - eng GR - 2023ysxk01/Health System Independent Innovation Science Foundation of Shanghai Putuo District/ GR - 2024tszk02/Clinical Characteristic of Health System in Putuo District, Shanghai/ GR - ptkwws202417/Shanghai Putuo District Health System/ GR - ptkwws202302/Shanghai Putuo District Health System/ GR - ptkwws202217/Shanghai Putuo District Health System/ GR - 202240309/Shanghai Municipal Health Commission/ GR - ptzygzs2409/Putuo Inheritance Studio of Renowned TCM Physician Chen Yuelai, Shanghai/ PT - Journal Article PL - United States TA - J Diabetes Res JT - Journal of diabetes research JID - 101605237 RN - 0 (Biomarkers) RN - 268B43MJ25 (Uric Acid) RN - 0 (Triglycerides) RN - 0 (Cholesterol, HDL) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/blood/complications/diagnosis MH - *Hyperuricemia/blood/diagnosis/complications MH - *Insulin Resistance/physiology MH - Middle Aged MH - Male MH - Female MH - Adult MH - Cross-Sectional Studies MH - Adolescent MH - Biomarkers/blood MH - Young Adult MH - *Uric Acid/blood MH - ROC Curve MH - Body Mass Index MH - Age Factors MH - Triglycerides/blood MH - Cholesterol, HDL/blood MH - Risk Factors PMC - PMC13324239 OTO - NOTNLM OT - Type 2 diabetes mellitus OT - hyperuricemia OT - insulin resistance COIS- The authors declare no conflicts of interest. EDAT- 2026/07/02 10:10 MHDA- 2026/07/02 10:11 PMCR- 2026/07/02 CRDT- 2026/07/02 03:24 PHST- 2026/06/02 00:00 [revised] PHST- 2025/07/10 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/02 10:11 [medline] PHST- 2026/07/02 10:10 [pubmed] PHST- 2026/07/02 03:24 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - JDR6682372 [pii] AID - 10.1155/jdr/6682372 [doi] PST - ppublish SO - J Diabetes Res. 2026;2026(1):e6682372. doi: 10.1155/jdr/6682372. PMID- 42387533 OWN - NLM STAT- MEDLINE DCOM- 20260920 LR - 20260923 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jul 1 TI - Deep learning-based dental age classification from panoramic radiographs: a multi-granularity, multi-model comparative study. LID - 10.1186/s12903-026-09068-x [doi] LID - 1774 AB - OBJECTIVE: To evaluate the performance of a hybrid deep learning architecture, MaxViT-T, for fine-grained dental age estimation (DAE) and coarse-grained age-group classification using panoramic radiographs, and to interpret the model's decision-making process through Explainable AI (XAI). MATERIALS AND METHODS: A dataset of n = 2,761 panoramic radiographs from patients aged 6-18 years was used. Two classification tasks were performed: a 13-class fine-grained age estimation and a 3-group coarse-grained age classification (age ranges 6-9, 10-13, and 14-18 years, approximating the early mixed, late mixed, and permanent dentition periods). The hybrid MaxViT-T model was compared against ten other architectures, including CNNs and Transformers, using 5-fold stratified cross-validation. Model interpretability was assessed using Grad-CAM and SHAP. RESULTS: MaxViT-T achieved the highest performance in both tasks. For the 13-class age estimation, it reached an accuracy of 0.4980 with a Mean Absolute Error (MAE) of 0.71 years. Tolerance-based accuracy increased to 84.9% and 96.1% within 1 and 2 years, respectively. For the 3-group age classification, the model achieved 91.13% accuracy and an AUC of 0.9669. XAI analyses confirmed that the model's attention shifted from deciduous teeth and erupting permanent teeth in younger ages to third molar development in older ages, predominantly focusing on the mandibular region. CONCLUSION: The hybrid MaxViT-T architecture achieved the highest accuracy for dental age estimation among the evaluated models, although its advantage over the leading CNN and Transformer architectures was not statistically significant. Its decision behavior aligned with established odontogenic developmental landmarks, supporting the biological plausibility of the learned features. CI - (c) 2026. The Author(s). FAU - Gorgun, Esin Akol AU - Gorgun EA AUID- ORCID: 0000-0002-6711-7188 AD - Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Adiyaman University, Altinsehir Neighborhood, 3005 Street No:13, Adiyaman, 02040, Turkey. esinakol@adiyaman.edu.tr. FAU - Cakmakoglu, Ezgi Eroglu AU - Cakmakoglu EE AUID- ORCID: 0000-0002-5014-3099 AD - Department of Pediatric Dentistry, Faculty of Dentistry, Adiyaman University, Adiyaman, 02040, Turkey. FAU - Sagmak, Savas AU - Sagmak S AUID- ORCID: 0000-0002-0082-6297 AD - Department of Restorative Dentistry, Faculty of Dentistry, Adiyaman University, Adiyaman, 02040, Turkey. FAU - Kutlu, Huseyin AU - Kutlu H AUID- ORCID: 0000-0003-0091-9984 AD - Department of Biostatistics and Medical Informatics, Faculty of Medicine, Adiyaman University, Adiyaman, 02040, Turkey. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260701 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Deep Learning MH - *Radiography, Panoramic MH - Child MH - Adolescent MH - *Age Determination by Teeth/methods PMC - PMC13591680 OTO - NOTNLM OT - Deep learning OT - Dental age estimation OT - Explainable artificial intelligence OT - Forensic dentistry OT - Hybrid models OT - Multi-granularity classification COIS- Declarations. Ethics approval and consent to participate: Ethical approval for this retrospective study was obtained from the Adiyaman University Non-Interventional Clinical Research Ethics Committee (Decision No: 2026/2-5). The requirement for informed consent to participate was waived by the same Ethics Committee due to the retrospective design of the study and the use of fully anonymized radiographic data, in accordance with national regulations governing retrospective studies using anonymized clinical data in Turkiye. All procedures were conducted in accordance with the principles of the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/02 10:10 MHDA- 2026/09/21 05:34 PMCR- 2026/07/01 CRDT- 2026/07/02 00:53 PHST- 2026/04/27 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/09/21 05:34 [medline] PHST- 2026/07/02 10:10 [pubmed] PHST- 2026/07/02 00:53 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 10.1186/s12903-026-09068-x [pii] AID - 9068 [pii] AID - 10.1186/s12903-026-09068-x [doi] PST - epublish SO - BMC Oral Health. 2026 Jul 1;26(1):1774. doi: 10.1186/s12903-026-09068-x. PMID- 42387491 OWN - NLM STAT- MEDLINE DCOM- 20260922 LR - 20260924 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jul 2 TI - Improving healthy eating behaviour among in-school adolescents through collaborative instructional intervention: a theory-driven quasi-experimental study. LID - 10.1186/s12889-026-28391-0 [doi] LID - 2641 AB - BACKGROUND: Adolescence is a critical window for establishing dietary behaviours that shape long-term health outcomes. In Nigeria and other Sub-Saharan African countries, school-based nutrition education has been largely ineffective when delivered through conventional didactic approaches. This study evaluated the effect of a Health Belief Model-guided collaborative learning intervention on diet quality, nutrition knowledge, and perceived dietary behaviour among in-school adolescents in Ogun State, Nigeria. METHODS: A quasi-experimental, pre-test-post-test control group design was used. Three hundred adolescents aged 13-19 years from two public secondary schools in Odeda Local Government Area were recruited, with 150 assigned to each group. The intervention group received eight weeks of structured nutrition education delivered through collaborative learning techniques, while the control group received the same content through conventional didactic instruction. Diet quality was assessed using the Global Diet Quality Questionnaire (DQQ), nutrition knowledge using a validated 20-item questionnaire, and perceived dietary behaviour using an HBM-based scale. Data were analysed using paired t-tests, independent t-tests, Difference-in-Differences analysis, and ANCOVA. RESULTS: The intervention group demonstrated statistically significant improvements in dietary diversity (DDS: 33.74%), NCD-Protect score (153.22%), and GDR score (39.86%), while the NCD-Risk score showed no significant change in either group (p = 0.967). Nutrition knowledge improved significantly in the intervention group (DiD = 7.94; p = 0.007), with no meaningful change in the control group. All six HBM constructs improved significantly in the intervention group, including self-efficacy (13.46%) and perceived severity (18.96%). ANCOVA confirmed that the intervention independently predicted improvements in both dietary diversity and nutrition knowledge after adjusting for baseline scores and sociodemographic covariates. CONCLUSIONS: The findings of this study suggest that collaborative learning-based nutrition education guided by the Health Belief Model was associated with meaningful improvements in diet quality, nutrition knowledge, and health beliefs among in-school adolescents. These findings support further evaluation of participatory and theory-driven instructional approaches within school-based nutrition programming in Nigeria and similar low-resource settings, ideally through cluster-randomised designs involving larger numbers of schools. CI - (c) 2026. The Author(s). FAU - Ademiluyi, Dare D AU - Ademiluyi DD AUID- ORCID: 0000-0003-3154-3924 AD - Department of Human Nutrition and Dietetics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria. ademiluyidare@gmail.com. FAU - Adepoju, Oladejo T AU - Adepoju OT AD - Department of Human Nutrition and Dietetics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria. FAU - Oladosu, Gbenga S AU - Oladosu GS AUID- ORCID: 0000-0003-1207-8000 AD - Department of Human Nutrition and Dietetics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria. AD - Department of Vocational Education (Home Economics Education Unit), Delta State University, Abraka, Delta State, Nigeria. FAU - Uthman-Akinhanmi, Yewande O AU - Uthman-Akinhanmi YO AUID- ORCID: 0000-0002-1033-2362 AD - Department of Home Science and Hospitality Management (Nutrition and Dietetics Unit), Olabisi Onabanjo University, Ago-iwoye, Ogun State, Nigeria. FAU - Akinsanya, Olubunmi B AU - Akinsanya OB AUID- ORCID: 0000-0002-2753-8463 AD - Department of Human Nutrition and Dietetics, Bells University of Technology, Ota, Ogun State, Nigeria. FAU - Adewale, Ifeyemi O AU - Adewale IO AD - Department of Food Science and Technology (Nutrition and Dietetics Unit), Bell University of Technology, Ota, Ogun State, Nigeria. FAU - Asha, Oluwatoyin E AU - Asha OE AD - Department of Agriculture and Agricultural Technology, Bells University of Technology, Ota, Ogun State, Nigeria. FAU - Olubiyi, Esther D AU - Olubiyi ED AUID- ORCID: 0009-0001-8048-5196 AD - Department of Nutrition and Dietetics, Federal Medical Centre, Abeokuta, Ogun State, Nigeria. FAU - Ojo-Adalumo, Ayobami R AU - Ojo-Adalumo AR AUID- ORCID: 0009-0005-6889-7322 AD - College of Nursing Science, Idi Aba, Abeokuta, Ogun State, Nigeria. FAU - Adepoju, Adeyinka B AU - Adepoju AB AUID- ORCID: 0009-0007-1012-7645 AD - Department of Nutrition and Dietetics, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria. FAU - Ogunniyi, Akinade E AU - Ogunniyi AE AUID- ORCID: 0009-0009-1961-3214 AD - Department of Human Nutrition and Dietetics, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria. FAU - Oyewunmi, Boluwatife T AU - Oyewunmi BT AUID- ORCID: 0009-0005-1927-4997 AD - Department of Nutrition and Dietetics, Federal University of Agriculture, Abeokuta, Ogun State, Nigeria. LA - eng PT - Journal Article DEP - 20260702 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - Nigeria MH - Female MH - *Diet, Healthy/psychology MH - Male MH - Young Adult MH - Health Knowledge, Attitudes, Practice MH - *Health Education/methods MH - Health Belief Model MH - Schools MH - Non-Randomized Controlled Trials as Topic MH - *School Health Services/organization & administration PMC - PMC13595612 OTO - NOTNLM OT - Adolescent nutrition OT - Collaborative learning OT - Diet quality OT - Health Belief Model OT - Nutrition education OT - Nutrition knowledge OT - School-based intervention COIS- Declarations. Ethics approval and consent to participate: Ethical clearance for this study was granted by the Health Research Ethics Committee of the Federal Medical Centre, Abeokuta (FMCA/470/HREC/17/2024/30). Throughout its conduct, the study adhered to internationally accepted ethical standards governing research involving human participants. Participation in this study was entirely voluntary and the study adhered to the tenets of the Helsinki Declaration at all stages. Before data collection commenced, all eligible students and their parents or guardians were provided with full information about the study's objectives, procedures, potential benefits, and the rights of participants. Written informed consent was secured from parents or legal guardians, and written informed assent was obtained from each adolescent participant. Taking part in the study was entirely voluntary, and all participants were made aware of their right to withdraw at any point without facing any consequence. To protect confidentiality, participants were assigned anonymised identification codes, and access to study data was limited strictly to members of the research team. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/02 06:39 MHDA- 2026/09/22 05:37 PMCR- 2026/07/02 CRDT- 2026/07/02 00:50 PHST- 2026/02/23 00:00 [received] PHST- 2026/06/29 00:00 [accepted] PHST- 2026/09/22 05:37 [medline] PHST- 2026/07/02 06:39 [pubmed] PHST- 2026/07/02 00:50 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - 10.1186/s12889-026-28391-0 [pii] AID - 28391 [pii] AID - 10.1186/s12889-026-28391-0 [doi] PST - epublish SO - BMC Public Health. 2026 Jul 2;26(1):2641. doi: 10.1186/s12889-026-28391-0. PMID- 42387446 OWN - NLM STAT- MEDLINE DCOM- 20260922 LR - 20260924 IS - 1472-6823 (Electronic) IS - 1472-6823 (Linking) VI - 26 IP - 1 DP - 2026 Jul 1 TI - Impact of growth hormone preparation switching on treatment outcomes in children with growth hormone deficiency: a retrospective real-world cohort study. LID - 10.1186/s12902-026-02395-8 [doi] LID - 286 AB - BACKGROUND: Switching between recombinant human growth hormone (rhGH) preparations has become increasingly common in pediatric practice because of reimbursement policies, product availability, and patient preferences. However, concerns persist regarding potential effects on growth outcomes and biochemical responses in real-world settings. This study aimed to evaluate whether switching growth hormone (GH) preparations is associated with differences in growth and biochemical outcomes compared with continuing the same product in children with growth hormone deficiency (GHD). METHODS: This single-center retrospective cohort study included 130 children with GHD receiving GH therapy between 2019 and 2024: 66 who underwent a single switch between preparations and 64 who continued the same product. Annualized changes in height standard deviation score (SDS), height velocity, insulin-like growth factor-1 (IGF-1) SDS, and insulin-like growth factor binding protein-3 (IGFBP-3) SDS were assessed over predefined 12-month observation windows. Patients were additionally stratified according to GHD severity, defined by a peak GH response < 7 ng/mL (severe/complete GHD) or 7-10 ng/mL (partial/borderline GHD). Within-group comparisons were performed using Wilcoxon signed-rank or Friedman tests, and between-group comparisons were performed using Mann-Whitney U tests or chi-square tests, as appropriate. Multivariate linear regression analyses adjusted for age, pubertal status, GH dose, baseline height SDS, and GHD severity. RESULTS: Baseline demographic, auxological, and perinatal characteristics were similar between the groups. In both cohorts, height SDS, IGF-1 SDS, and IGFBP-3 SDS improved significantly during follow-up, whereas GH dose remained stable. When outcomes were compared during equivalent treatment intervals, no significant differences were observed between the switch and nonswitch groups in height velocity (8.72 +/- 2.64 vs. 8.42 +/- 1.62 cm/year; p = 0.108), DeltaHeight SDS (0.53 +/- 0.51 vs. 0.39 +/- 0.37; p = 0.206), DeltaIGF-1 SDS (0.82 +/- 0.69 vs. 0.71 +/- 0.54; p = 0.486), or DeltaIGFBP-3 SDS (0.86 +/- 0.90 vs. 0.64 +/- 0.45; p = 0.283). Similar findings were observed in patients with severe GHD (peak GH < 7 ng/mL). Multivariate regression analysis identified baseline height SDS and GH dose as independent predictors of 12-month height SDS change, whereas switch status and GHD severity were not independently associated with growth response. CONCLUSIONS: Switching between rhGH preparations was not associated with impaired growth or adverse biochemical outcomes in children with GHD. Growth and biochemical responses were comparable between switched and nonswitched patients during equivalent treatment intervals, including among patients with severe GHD. These findings support the clinical feasibility of switching between daily rhGH preparations when required because of reimbursement policies, product availability, or other practical clinical considerations. TRIAL REGISTRATION: Not applicable. CI - (c) 2026. The Author(s). FAU - Deligozoglu, Duygu AU - Deligozoglu D AUID- ORCID: 0000-0002-4804-3048 AD - Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Turkey. dyg_ertn@hotmail.com. FAU - Gokdemir, Irem AU - Gokdemir I AUID- ORCID: 0009-0002-2967-6437 AD - Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Turkey. FAU - Genc, Can Alp AU - Genc CA AUID- ORCID: 0000-0003-0756-9745 AD - Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Turkey. FAU - Buyukyilmaz, Gonul AU - Buyukyilmaz G AUID- ORCID: 0000-0001-7888-7295 AD - Department of Pediatric Endocrinology, Ankara Yildirim Beyazit University, Ankara, Turkey. FAU - Cetin, Sirmen Kizilcan AU - Cetin SK AUID- ORCID: 0000-0001-7397-3071 AD - Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Turkey. FAU - Isik, Emregul AU - Isik E AUID- ORCID: 0000-0003-0162-6745 AD - Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Turkey. FAU - Sengil, Hande Nur AU - Sengil HN AUID- ORCID: 0009-0006-9024-6283 AD - Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Turkey. FAU - Tepe, Derya AU - Tepe D AUID- ORCID: 0000-0002-2935-3008 AD - Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Turkey. FAU - Kocaay, Pinar AU - Kocaay P AUID- ORCID: 0000-0003-0850-0360 AD - Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Turkey. FAU - Boyraz, Mehmet AU - Boyraz M AUID- ORCID: 0000-0002-4289-9128 AD - Department of Pediatric Endocrinology, Ankara Yildirim Beyazit University, Ankara, Turkey. FAU - Gurbuz, Fatih AU - Gurbuz F AUID- ORCID: 0000-0003-2160-9838 AD - Department of Pediatric Endocrinology, Ankara City Hospital, Ankara, Turkey. AD - Department of Pediatric Endocrinology, Ankara Yildirim Beyazit University, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260701 PL - England TA - BMC Endocr Disord JT - BMC endocrine disorders JID - 101088676 RN - 12629-01-5 (Human Growth Hormone) RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 0 (Recombinant Proteins) RN - 0 (Insulin-Like Growth Factor Binding Protein 3) RN - 0 (IGF1 protein, human) SB - IM MH - Humans MH - Retrospective Studies MH - *Human Growth Hormone/deficiency/therapeutic use/administration & dosage MH - Female MH - Male MH - Child MH - Insulin-Like Growth Factor I/analysis/metabolism MH - Treatment Outcome MH - Body Height/drug effects MH - Follow-Up Studies MH - Recombinant Proteins/administration & dosage MH - *Growth Disorders/drug therapy MH - Adolescent MH - Insulin-Like Growth Factor Binding Protein 3/blood MH - *Drug Substitution MH - Prognosis MH - Child, Preschool PMC - PMC13595697 OTO - NOTNLM OT - Growth hormone deficiency OT - Growth hormone therapy OT - Growth response OT - Real-world study OT - Treatment switch COIS- Declarations. Ethics approval and consent to participate: This retrospective study involving human participant data was approved by the Institutional Ethics Committee of Ankara Bilkent City Hospital (Approval No: 2-24-516; Date: 18 September 2024). The requirement for informed consent to participate was waived by the ethics committee due to the retrospective design of the study, which used anonymized electronic medical records without direct patient contact. All procedures were conducted in accordance with the ethical standards of the institutional research committee and with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/02 06:37 MHDA- 2026/09/22 05:37 PMCR- 2026/07/01 CRDT- 2026/07/02 00:47 PHST- 2026/02/08 00:00 [received] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/09/22 05:37 [medline] PHST- 2026/07/02 06:37 [pubmed] PHST- 2026/07/02 00:47 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 10.1186/s12902-026-02395-8 [pii] AID - 2395 [pii] AID - 10.1186/s12902-026-02395-8 [doi] PST - epublish SO - BMC Endocr Disord. 2026 Jul 1;26(1):286. doi: 10.1186/s12902-026-02395-8. PMID- 42386993 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 7 DP - 2026 Jul 2 TI - Validity and reliability of the Turkish version of the Physical Activity Parenting Questionnaire for Children. LID - 546 [pii] LID - 10.1007/s00431-026-07210-z [doi] AB - Parental practices play a critical role in shaping children's physical activity behaviors, particularly during early school age when parental influence remains strong. The Physical Activity Parenting Questionnaire for Children (PAP-C) is a child-reported, multidimensional instrument designed for children aged 7-10 years; however, no validated Turkish version is currently available. This study aimed to translate, culturally adapt, and evaluate the validity and reliability of the Turkish version of the PAP-C. This methodological, cross-sectional study included 279 children aged 7-10 years attending a pediatric outpatient clinic in Turkiye. The PAP-C was translated and culturally adapted following internationally accepted guidelines. Content validity was assessed. Construct validity was examined using confirmatory factor analysis (CFA). Reliability was evaluated using Cronbach's alpha and McDonald's omega. The study included 279 children (mean age: 8.6 years). The Turkish PAP-C demonstrated strong content validity (S-CVI). Sociodemographic variables showed no significant differences in scale scores, except for higher Involvement scores in children whose fathers had primary school education (p = 0.033). Confirmatory factor analysis confirmed an acceptable to good model fit (CFI: 0.923, TLI: 0.913, RMSEA: 0.055). Standardized factor loadings ranged from 0.599 to 0.866. All subscales exceeded empirical thresholds for convergent validity. The total scale showed good reliability (Omega: 0.951). HTMT values confirmed distinct discriminant validity among the three latent factors. CONCLUSION: The Turkish version of the PAP-C is a valid and reliable instrument for assessing children's perceptions of physical activity related parenting practices. It provides a culturally appropriate tool for both research and clinical assessment. WHAT IS KNOWN: * Parental practices are key determinants of children's physical activity behaviors, and children's perceptions of parenting are closely linked to motivation and engagement. * The Physical Activity Parenting Questionnaire for Children is a child-reported, multidimensional instrument grounded in Self-Determination Theory, capturing three parenting domains (Structure for Activity, Autonomy Support, and Involvement) and has been validated only in limited cultural contexts. WHAT IS NEW: * This study provides the first Turkish translation, cultural adaptation, and psychometric evaluation of the Physical Activity Parenting Questionnaire for Children in children aged 7-10 years. * Content validity was established with high item-level content validity index and scale-level content validity index based on the average method scores, demonstrating strong expert agreement on item relevance and cultural appropriateness. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Sivlim, Harun AU - Sivlim H AUID- ORCID: 0000-0003-3184-5519 AD - Bayburt Provincial Directorate of Health, Bayburt, Turkiye. FAU - Come, Ogulcan AU - Come O AUID- ORCID: 0000-0002-6624-832X AD - Faculty of Medicine, Department of Family Medicine, Dokuz Eylul University, Izmir, Turkey. ogulcancome@gmail.com. FAU - Laukkanen, Arto AU - Laukkanen A AUID- ORCID: 0000-0002-9722-0258 AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. LA - eng PT - Journal Article PT - Validation Study DEP - 20260702 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Child MH - Male MH - Reproducibility of Results MH - Turkey MH - Female MH - Cross-Sectional Studies MH - Surveys and Questionnaires/standards MH - *Exercise/psychology MH - *Parenting/psychology MH - Psychometrics MH - Factor Analysis, Statistical MH - Translations MH - Parent-Child Relations OTO - NOTNLM OT - Child-report OT - Parenting practices OT - Physical activity OT - Questionnaire validation OT - Reliability COIS- Declarations. Conflict of interest: The authors declare no competing interests. Declaration of generative AI and AI-assisted technologies: During the preparation of this work, the author(s) used ChatGPT-4o (OpenAI, 2025) in order to improve grammar, language clarity, and phrasing. After using this tool/service, the author(s) reviewed and edited the content as needed and take(s) full responsibility for the content of the publication. EDAT- 2026/07/02 00:33 MHDA- 2026/07/02 00:34 CRDT- 2026/07/01 23:42 PHST- 2026/02/03 00:00 [received] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/06/21 00:00 [revised] PHST- 2026/07/02 00:34 [medline] PHST- 2026/07/02 00:33 [pubmed] PHST- 2026/07/01 23:42 [entrez] AID - 10.1007/s00431-026-07210-z [pii] AID - 10.1007/s00431-026-07210-z [doi] PST - epublish SO - Eur J Pediatr. 2026 Jul 2;185(7):546. doi: 10.1007/s00431-026-07210-z. PMID- 42386292 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 7 DP - 2026 Jul 1 TI - Physical Literacy through Active plaY and environmental affordances in outdoor kindergarten settings: a multidimensional approach to Unveiling Potential (PLAY UP) - study protocol for a cluster-randomised trial. PG - e120976 LID - 10.1136/bmjopen-2026-120976 [doi] LID - e120976 AB - INTRODUCTION: Outdoor active play is essential for children's health, well-being and holistic development. However, there is a lack of high-quality evidence on effective sustainable and scalable interventions that leverage outdoor play and environmental affordances to promote physical literacy, including motor competence, physical activity, engagement and motivation for movement in early childhood. In particular, limited research has examined how outdoor kindergarten environments can be intentionally used and optimised to support diverse forms of active play through social and other potential affordances, nor how educators can be supported to facilitate such processes. The PLAY UP project aims to address this gap by investigating how a co-created, affordance-based intervention, developed in collaboration with children and supported by educator training, can enhance preschool children's engagement in active play and multidimensional development in outdoor kindergarten settings. METHODS AND ANALYSIS: This study describes the protocol of a cluster-randomised trial to be conducted in Portugal, involving three kindergartens and up to 215 preschool children, their educators and parents. The protocol includes an initial pilot phase (approximately 75 children from one kindergarten) to assess feasibility, acceptability and implementation procedures, followed by a main study phase with intervention and wait-list control clusters. The intervention comprises 15 sessions delivered in outdoor kindergarten settings. PLAY UP adopts a multidimensional and multimethod approach combining quantitative and qualitative methods. Outcomes related to physical literacy, including physical activity, motor competence, engagement, enjoyment and motivation for movement, are assessed using questionnaires, standardised tasks, accelerometry, Global Positioning System-based positioning technologies and systematic observations, complemented by interviews. Data will be analysed using cluster-aware statistical models and integrative mixed-methods approaches. ETHICS AND DISSEMINATION: This study has been approved by the Ethics Committee of the University of Evora (Ref. #24101). Written informed consent was obtained from parents or legal guardians, and all data will be handled confidentially in accordance with ethical and data protection standards. Study findings will be disseminated through open-access peer-reviewed publications, scientific conferences and knowledge-transfer activities targeting education professionals and relevant stakeholders. TRIAL REGISTRATION NUMBER: NCT07355179. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Almeida, Gabriela AU - Almeida G AUID- ORCID: 0000-0002-6716-2114 AD - Department of Sport and Health, University of Evora, School of Health and Human Development, Evora, Portugal gsna@uevora.pt. AD - Comprehensive Health Research Centre (CHRC), Universidade de Evora, Evora, Portugal. FAU - Goncalves, Bruno AU - Goncalves B AD - Department of Sport and Health, University of Evora, School of Health and Human Development, Evora, Portugal. AD - Comprehensive Health Research Centre (CHRC), Universidade de Evora, Evora, Portugal. FAU - Luz, Carlos AU - Luz C AD - Escola Superior de Educacao de Lisboa, Ci&DEI, Instituto Politecnico de Lisboa, Lisbon, Portugal. FAU - Galhardas, Luis AU - Galhardas L AD - Department of Sport and Health, University of Evora, School of Health and Human Development, Evora, Portugal. AD - Comprehensive Health Research Centre (CHRC), Universidade de Evora, Evora, Portugal. FAU - Bilton, Helen AU - Bilton H AD - Institute of Education, University of Reading, Reading, UK. FAU - Marmeleira, Jose AU - Marmeleira J AD - Department of Sport and Health, University of Evora, School of Health and Human Development, Evora, Portugal. AD - Comprehensive Health Research Centre (CHRC), Universidade de Evora, Evora, Portugal. LA - eng SI - ClinicalTrials.gov/NCT07355179 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260701 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Play and Playthings MH - Child, Preschool MH - *Exercise MH - Portugal MH - Randomized Controlled Trials as Topic MH - Schools MH - Research Design PMC - PMC13358333 OTO - NOTNLM OT - child education OT - health OT - intervention OT - physical fitness COIS- Competing interests: None declared. EDAT- 2026/07/02 04:10 MHDA- 2026/07/02 04:11 PMCR- 2026/07/01 CRDT- 2026/07/01 21:03 PHST- 2026/07/02 04:11 [medline] PHST- 2026/07/02 04:10 [pubmed] PHST- 2026/07/01 21:03 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - bmjopen-2026-120976 [pii] AID - 10.1136/bmjopen-2026-120976 [doi] PST - epublish SO - BMJ Open. 2026 Jul 1;16(7):e120976. doi: 10.1136/bmjopen-2026-120976. PMID- 42385346 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20260916 IS - 1875-595X (Electronic) IS - 0020-6539 (Print) IS - 0020-6539 (Linking) VI - 76 IP - 5 DP - 2026 Oct TI - CBCT-Based Clinico-Radiomic Nomogram Predicting Preoperative Mandibular Third Molar Difficulty: Development/Validation. PG - 109714 LID - S0020-6539(26)00307-2 [pii] LID - 10.1016/j.identj.2026.109714 [doi] LID - 109714 AB - OBJECTIVE: This study aimed to develop and validate a clinico-radiomic nomogram, integrating Cone-Beam Computed Tomography (CBCT) radiomic features with clinical characteristics, to predict the difficulty of mandibular third molar (MTM) extraction. METHODS: A retrospective cohort of 600 patients undergoing MTM extraction was divided into training and validation sets. Radiomic features were extracted from preoperative CBCT images. The Least Absolute Shrinkage and Selection Operator (LASSO) method was used to select key features and build a radiomic score (Rad-score). Multivariable logistic regression identified independent clinical predictors. A final nomogram was established by combining the Rad-score and clinical factors. The model's performance was assessed for discrimination (AUC), calibration (Hosmer-Lemeshow test), and clinical utility (Decision Curve Analysis - DCA). RESULTS: Eleven robust features were selected to construct a radiomic signature. The Rad-score was significantly higher in the high-difficulty group (P < .001). Five independent predictors were identified: Age, BMI, Pell & Gregory classification, Root Curvature, and the Rad-score. The combined clinico-radiomic nomogram demonstrated superior predictive performance in both training (AUC = 0.892) and validation (AUC = 0.865) cohorts, significantly outperforming models based solely on clinical or radiomic factors alone. The model showed excellent calibration between predicted and observed probabilities and demonstrated substantial clinical net benefit via DCA. CONCLUSION: The novel CBCT-based clinico-radiomic nomogram provides a noninvasive, accurate, and visual tool for the preoperative stratification of MTM extraction difficulty. This facilitates more informed surgical planning and personalised patient counselling. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Xu, Mingchen AU - Xu M AD - Department of Emergency General, Wuxi Stomatological Hospital, Wuxi City, Jiangsu Province, China. FAU - Wu, Yijun AU - Wu Y AD - Department of Emergency General, Wuxi Stomatological Hospital, Wuxi City, Jiangsu Province, China. Electronic address: 15906176640@163.com. LA - eng PT - Journal Article PT - Validation Study DEP - 20260701 PL - England TA - Int Dent J JT - International dental journal JID - 0374714 SB - IM MH - Humans MH - *Nomograms MH - *Cone-Beam Computed Tomography/methods MH - *Molar, Third/surgery/diagnostic imaging MH - Female MH - Radiomics MH - Retrospective Studies MH - Male MH - Adult MH - *Tooth Extraction/methods MH - Mandible/diagnostic imaging/surgery MH - Young Adult MH - *Tooth, Impacted/surgery/diagnostic imaging MH - Adolescent PMC - PMC13355169 OTO - NOTNLM OT - Cone-beam computed tomography OT - Mandibular third molar OT - Nomogram OT - Radiomics OT - Tooth extraction EDAT- 2026/07/02 04:10 MHDA- 2026/09/16 05:36 PMCR- 2026/07/01 CRDT- 2026/07/01 18:02 PHST- 2026/04/15 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/09/16 05:36 [medline] PHST- 2026/07/02 04:10 [pubmed] PHST- 2026/07/01 18:02 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - S0020-6539(26)00307-2 [pii] AID - 109714 [pii] AID - 10.1016/j.identj.2026.109714 [doi] PST - ppublish SO - Int Dent J. 2026 Oct;76(5):109714. doi: 10.1016/j.identj.2026.109714. Epub 2026 Jul 1. PMID- 42385041 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260813 IS - 1806-9282 (Electronic) IS - 0104-4230 (Print) IS - 0104-4230 (Linking) VI - 72 IP - 4 DP - 2026 TI - Association of immunonutrition-based indices (Hemoglobin-Albumin-Lymphocyte-Platelet, prognostic nutritional index, and C-reactive protein-albumin-lymphocyte) with the latency period in preterm prelabor rupture of membranes. PG - e20251977 LID - S0104-42302026000402216 [pii] LID - 10.1590/1806-9282.20251977 [doi] LID - e20251977 AB - OBJECTIVE: The aim of this study was to evaluate the predictive value of immunonutrition-based indices (Hemoglobin, Albumin, Lymphocyte, Platelet score, prognostic nutritional index, and C-reactive protein-albumin-lymphocyte index) for latency duration and neonatal outcomes in preterm prelabor rupture of membranes. METHODS: This retrospective cohort study included 145 singleton pregnancies diagnosed with PPROM between 24 and 34 weeks. Patients were categorized by latency duration (48 h), and subgroup analyses used thresholds of 72 h, 96 h, and 7 days. Maternal, laboratory, and neonatal characteristics were compared. Logistic regression adjusted for parity and gestational age evaluated associations between indices and latency. RESULTS: Hemoglobin, Albumin, Lymphocyte, Platelet, prognostic nutritional index, and C-reactive protein-albumin-lymphocyte values showed no significant differences across latency groups (all p>0.05). Only respiratory distress syndrome was more frequent in the short-latency group (p=0.005). CONCLUSION: Immunonutrition indices remained stable across latency durations, highlighting the predominance of localized inflammatory and structural mechanisms in preterm prelabor rupture of membranes pathophysiology. FAU - Arzik, Ilayda Gercik AU - Arzik IG AUID- ORCID: 0000-0001-7308-352X AD - Izmir City Hospital, Department of Perinatology - Izmir, Turkey. FAU - Golbasi, Hakan AU - Golbasi H AUID- ORCID: 0000-0001-8682-5537 AD - Izmir City Hospital, Department of Perinatology - Izmir, Turkey. FAU - Aktas, Hale Ankara AU - Aktas HA AUID- ORCID: 0000-0002-0723-4948 AD - Izmir City Hospital, Department of Perinatology - Izmir, Turkey. FAU - Toka, Ilknur AU - Toka I AUID- ORCID: 0000-0002-3804-2826 AD - Izmir City Hospital, Department of Perinatology - Izmir, Turkey. FAU - Cakir, Zubeyde Emiralioglu AU - Cakir ZE AUID- ORCID: 0000-0001-8298-8363 AD - Izmir City Hospital, Department of Perinatology - Izmir, Turkey. FAU - Purut, Ceren Saglam AU - Purut CS AUID- ORCID: 0000-0001-6013-6602 AD - Izmir City Hospital, Department of Perinatology - Izmir, Turkey. FAU - Torun, Raziye AU - Torun R AUID- ORCID: 0000-0002-0272-7196 AD - Izmir City Hospital, Department of Perinatology - Izmir, Turkey. FAU - Bayram, Emre AU - Bayram E AUID- ORCID: 0000-0002-2333-6805 AD - Izmir City Hospital, Department of Perinatology - Izmir, Turkey. FAU - Bayraktar, Burak AU - Bayraktar B AUID- ORCID: 0000-0001-6233-4207 AD - University of Health Sciences, Ankara Etlik City Hospital, Department of Perinatology - Ankara, Turkey. AD - University of Health Sciences, Ankara Etlik City Hospital, Department of Obstetrics and Gynecology, Division of Perinatology - Ankara, Turkey. FAU - Ekin, Atalay AU - Ekin A AUID- ORCID: 0000-0002-4712-3927 AD - Izmir City Hospital, Department of Perinatology - Izmir, Turkey. LA - eng PT - Journal Article DEP - 20260629 PL - Brazil TA - Rev Assoc Med Bras (1992) JT - Revista da Associacao Medica Brasileira (1992) JID - 9308586 RN - 9007-41-4 (C-Reactive Protein) RN - 0 (Hemoglobins) RN - 0 (Serum Albumin) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Premature Rupture of Fetal Membranes/blood/immunology MH - Retrospective Studies MH - *C-Reactive Protein/analysis MH - Adult MH - Prognosis MH - Hemoglobins/analysis MH - Infant, Newborn MH - Serum Albumin/analysis MH - *Nutrition Assessment MH - Gestational Age MH - Predictive Value of Tests MH - Time Factors MH - Biomarkers/blood MH - Immunonutrition Diet MH - Nutritional Status MH - Lymphocytes PMC - PMC13313070 COIS- Conflicts of interest: the authors declare there is no conflicts of interest. EDAT- 2026/07/01 18:33 MHDA- 2026/07/01 18:34 PMCR- 2026/06/29 CRDT- 2026/07/01 15:44 PHST- 2025/11/09 00:00 [received] PHST- 2026/01/24 00:00 [accepted] PHST- 2026/07/01 18:34 [medline] PHST- 2026/07/01 18:33 [pubmed] PHST- 2026/07/01 15:44 [entrez] PHST- 2026/06/29 00:00 [pmc-release] AID - S0104-42302026000402216 [pii] AID - 10.1590/1806-9282.20251977 [doi] PST - epublish SO - Rev Assoc Med Bras (1992). 2026 Jun 29;72(4):e20251977. doi: 10.1590/1806-9282.20251977. eCollection 2026. PMID- 42385006 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260813 IS - 1678-4464 (Electronic) IS - 0102-311X (Print) IS - 0102-311X (Linking) VI - 42 DP - 2026 TI - Feasibility of a generative AI chatbot to support breastfeeding in the Brazilian Unified National Health System. PG - e00117825 LID - S0102-311X2026000105046 [pii] LID - 10.1590/0102-311XEN117825 [doi] LID - e00117825 AB - This exploratory feasibility study aimed to evaluate the usability, user experience, and preliminary impacts of a generative language model-based chatbot (Lhia 2.0) on maternal self-efficacy and attitudes toward breastfeeding. A total of 13 mothers receiving care at the Human Milk Bank of the University Hospital of the Federal University of Maranhao interacted with the chatbot via WhatsApp over 15 days. The following instruments were applied before and after the use of Lhia 2.0: the Breastfeeding Self-Efficacy Scale - Short Form (BSES-SF) and the Iowa Infant Feeding Attitude Scale (IIFAS). The User Experience Questionnaire - Short Version (UEQ-S) was applied after the interaction. Results indicated excellent usability (pragmatic quality = +2.36; hedonic quality = +2.57) and high engagement (average interaction time = 92 minutes). Statistically significant improvements were observed in BSES-SF (mean difference = 3.00; p = 0.042; Cohen's d = 0.778) and in IIFAS (mean difference = 3.50; p = 0.021; Cohen's d = 0.778). The results indicated high acceptance among mothers, with notable user engagement, excellent perceived usability, and positive effects on confidence and attitudes toward breastfeeding. Based on these findings, Lhia 2.0 is considered a feasible and promising tool for integration into breastfeeding promotion strategies, particularly within the context of the Brazilian Unified National Health System. FAU - Araujo Neto, Ari Pereira de AU - Araujo Neto AP AUID- ORCID: 0000-0001-6903-4127 AD - Universidade Federal do Delta do Parnaiba, Parnaiba, Brasil. AD - Hospital Universitario da Universidade Federal do Maranhao, Sao Luis, Brasil. FAU - Pinto, Giovanny Reboucas AU - Pinto GR AUID- ORCID: 0000-0001-9110-1840 AD - Universidade Federal do Delta do Parnaiba, Parnaiba, Brasil. FAU - Oliveira, Adonias Caetano de AU - Oliveira AC AUID- ORCID: 0000-0002-5643-2916 AD - Universidade Federal do Delta do Parnaiba, Parnaiba, Brasil. AD - Instituto Federal de Educacao, Ciencia e Tecnologia do Ceara, Tiangua, Brasil. FAU - Chagas, Simone Nunes Leal AU - Chagas SNL AUID- ORCID: 0000-0002-9536-9315 AD - Hospital Universitario da Universidade Federal do Maranhao, Sao Luis, Brasil. FAU - Conceicao, Francilidia Oliveira Vitorino de Assuncao AU - Conceicao FOVA AUID- ORCID: 0000-0002-0079-7502 AD - Universidade Federal do Maranhao, Sao Luis, Brasil. FAU - Teles, Ariel Soares AU - Teles AS AUID- ORCID: 0000-0002-0840-3870 AD - Programa de Pos-graduacao em Biotecnologia, Universidade Federal do Delta do Parnaiba, Parnaiba, Brasil. LA - eng PT - Journal Article DEP - 20260626 PL - Brazil TA - Cad Saude Publica JT - Cadernos de saude publica JID - 8901573 SB - IM MH - Humans MH - *Breast Feeding/psychology MH - Female MH - Brazil MH - Adult MH - Feasibility Studies MH - Surveys and Questionnaires MH - Self Efficacy MH - Generative Artificial Intelligence MH - *Mothers/psychology MH - National Health Programs MH - Young Adult PMC - PMC13313153 EDAT- 2026/07/01 18:33 MHDA- 2026/07/01 18:34 PMCR- 2026/06/26 CRDT- 2026/07/01 15:43 PHST- 2025/06/16 00:00 [received] PHST- 2026/01/07 00:00 [accepted] PHST- 2026/07/01 18:34 [medline] PHST- 2026/07/01 18:33 [pubmed] PHST- 2026/07/01 15:43 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - S0102-311X2026000105046 [pii] AID - 10.1590/0102-311XEN117825 [doi] PST - epublish SO - Cad Saude Publica. 2026 Jun 26;42:e00117825. doi: 10.1590/0102-311XEN117825. eCollection 2026. PMID- 42384157 OWN - NLM STAT- MEDLINE DCOM- 20260721 LR - 20260813 IS - 1573-3521 (Electronic) IS - 0160-7715 (Print) IS - 0160-7715 (Linking) VI - 49 IP - 4 DP - 2026 Aug TI - Ecological predictors of daily dietary intake in black adolescents with overweight and obesity in the families improving together (FIT) for weight loss trial. PG - 631-643 LID - 10.1007/s10865-026-00686-y [doi] AB - Healthful eating habits (i.e., increased fruit and vegetable and decreased hyperpalatable energy-dense food and drink consumption) are important for preventing chronic disease risk (e.g., obesity) and improving overall health in Black adolescents.This study examines the intrapersonal, interpersonal, and environmental factors associated with daily dietary intake in Black adolescents with overweight and obesity. Baseline data were analyzed from 241 Black parent-adolescent dyads who participated in the Families Improving Together (FIT) for Weight Loss trial (Adolescent: Mage = 12.8 years, SD = 1.8; 63% female; MBMI% = 96.6, SD = 4.3). Intrapersonal factors included dietary motivation. Interpersonal factors included social support for diet from family. Environmental factors included access to food in the home. Dietary outcomes were measured using validated adolescent self-reported surveys. Separate multiple linear regressions revealed several associations between ecological factors and daily food intake. Greater access to more-healthful foods was associated with increased daily vegetable intake (beta = 0.18, SE = 0.08, p < .05), whereas greater access to less-healthful foods was associated with increased daily fruit intake (beta = 0.24, SE = 0.08, p < .05). Greater access to less-healthful foods was associated with increased daily energy-dense food intake (beta = 0.75, SE = 0.10, p < .001), whereas increased self-reported dietary motivation was associated with decreased daily energy-dense food intake (beta = -0.24, SE = 0.10, p < .05). Greater access to less-healthful foods (beta = 1.48, SE = 0.23, p < .001) and higher adolescent BMI (beta = 0.84, SE = 0.40, p < .05) was also associated with increased sugar-sweetened beverage consumption. These findings suggest that access to more-healthful foods is associated with greater vegetable intake, while restricting access to less-healthful foods and increased motivation for more healthful eating were associated with lower sugar-sweetened beverage and energy-dense food consumption among Black adolescents. These findings may inform future health promotion programs across various ecological levels of dietary behaviors in Black youth with overweight and obesity. CI - (c) 2026. The Author(s). FAU - White, Taylor R AU - White TR AUID- ORCID: 0000-0001-6540-0994 AD - Department of Psychology, University of South Carolina, Columbia, SC, USA. trw9@email.sc.edu. FAU - Wilson, Dawn K AU - Wilson DK AD - Department of Psychology, University of South Carolina, Columbia, SC, USA. FAU - Tucker, Sonali AU - Tucker S AD - Department of Psychology, University of South Carolina, Columbia, SC, USA. FAU - Sweeney, Allison AU - Sweeney A AD - School of Nursing, University of South Carolina, Columbia, SC, USA. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260701 PL - United States TA - J Behav Med JT - Journal of behavioral medicine JID - 7807105 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Black or African American/psychology MH - Diet MH - Diet, Healthy MH - *Feeding Behavior/ethnology/psychology MH - Motivation MH - *Pediatric Obesity/ethnology/psychology/therapy MH - Social Support MH - Weight Loss PMC - PMC13385267 OTO - NOTNLM OT - Adolescent OT - Black or African American OT - Diet OT - Ecological OT - Food availability OT - Obesity COIS- Declarations. Conflict of interest: The authors declare no conflicts of interest. Ethical approval: The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board of the University of South Carolina (Protocol Code: Pro00016136, approved January 23, 2013). Consent to participate: Informed consent and assent were obtained from all subjects involved in the study. Trial registration: The FIT trial was registered on January 23, 2013, on ClinicalTrials.gov NCT01796067. EDAT- 2026/07/01 16:11 MHDA- 2026/07/21 06:34 PMCR- 2026/07/01 CRDT- 2026/07/01 11:06 PHST- 2025/12/12 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/07/21 06:34 [medline] PHST- 2026/07/01 16:11 [pubmed] PHST- 2026/07/01 11:06 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 10.1007/s10865-026-00686-y [pii] AID - 686 [pii] AID - 10.1007/s10865-026-00686-y [doi] PST - ppublish SO - J Behav Med. 2026 Aug;49(4):631-643. doi: 10.1007/s10865-026-00686-y. Epub 2026 Jul 1. PMID- 42382932 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 2094-9278 (Electronic) IS - 0001-6071 (Print) IS - 0001-6071 (Linking) VI - 60 IP - 10 DP - 2026 TI - Philippine Clinical Practice Guidelines for Periodic Health Examination: Screening for Prenatal Disorders. PG - 210-227 LID - 10.47895/amp.v60i10.13595 [doi] AB - BACKGROUND: The Philippine Guidelines on Periodic Health Examination (PHEX) support the Universal Health Care Act by providing guidance on quality, accessible, and affordable screening services for Filipinos. Conditions that develop in the prenatal period are a major cause of neonatal deaths in the Philippines and account for 14% of deaths in children under five. OBJECTIVES: This guideline aims to provide evidence-based recommendations for screening prenatal disorders among asymptomatic, pregnant Filipino women. It also aims to equip general practitioners, obstetricsgynecology specialists, allied health professionals, patients, policymakers, regulatory agencies, and healthcare institutions with tools and guidance that facilitate informed, evidence-based healthcare decisions for pregnant women. METHODS: The development of this CPG followed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to CPG development recommended in the Department of Health (DOH) Manual. Recommendations were finalized using the Evidence-to-Decision (EtD) framework. Evidence Review Experts conducted a systematic literature search and critically appraised recent local and international clinical guidelines. When necessary, they conducted de novo systematic reviews. Information on the benefits and harms of screening, cost-effectiveness, patient values and preferences, acceptability, feasibility, and its impact on equity was obtained. A multisectoral consensus panel reviewed the evidence and developed recommendations. A user-friendly web application and engagement with stakeholders for promotion and implementation were among the dissemination strategies. Experts conducted an external review to provide feedback on the methodology and recommendations. RESULTS: Eleven recommendations for different screening strategies to improve the health outcomes of pregnant women and neonates were developed. This CPG contains recommendations for the screening for maternal thyroid disease, gestational diabetes mellitus, group B Streptococcus infection, fetal aneuploidy, risk for preeclampsia, iron deficiency anemia, and undernutrition, and conducting cervical length measurements, first-trimester ultrasound, and second-trimester ultrasound. CONCLUSION: This CPG provides 11 evidence-based recommendations. Applicability in the local setting was carefully considered through the involvement of different stakeholders. The recommendations herein shall hold until new evidence on screening, diagnosing, or managing various risk factors and diseases emerges, or contingencies dictate updating this CPG. This guideline will be updated after three (3) years. CI - (c) 2026 Acta Medica Philippina. FAU - Germar, Maria Julieta Corazon V AU - Germar MJCV AD - College of Medicine, University of the Philippines Manila, Manila, Philippines. FAU - Palileo-Villanueva, Lia M AU - Palileo-Villanueva LM AD - College of Medicine, University of the Philippines Manila, Manila, Philippines. FAU - Suplido, Sherri Ann L AU - Suplido SAL AD - Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Villaluz, Ma Susan B AU - Villaluz MSB AD - Cebu Puericulture Center and Maternity House, Inc., Cebu, Philippines. FAU - Gianan, Mike Justin A AU - Gianan MJA AD - Department of Family and Community Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Sy, Endrik H AU - Sy EH AD - Baguio General Hospital and Medical Center, Benguet, Philippines. FAU - Castillo, Betha Fe M AU - Castillo BFM AD - Dagupan Doctors Villaflor Memorial Hospital, Pangasinan, Philippines. FAU - Boransing, Potre Mairasna P AU - Boransing PMP AD - Amai Pakpak Medical Center, Marawi City, Philippines. FAU - De Peralta-Yambao, Helen B AU - De Peralta-Yambao HB AD - Cotabato Regional and Medical Center, Cotabato City, Philippines. FAU - Cacas, Maria Theresa G AU - Cacas MTG AD - University of the East Ramon Magsaysay Medical Center, Quezon City, Philippines. FAU - Besa, John Jefferson V AU - Besa JJV AD - College of Medicine, University of the Philippines Manila, Manila, Philippines. FAU - Masamayor, Ella Mae I AU - Masamayor EMI AD - Department of Medicine, University of the Philippines Manila, Manila, Philippines. FAU - Malijan, Greco Mark B AU - Malijan GMB AD - Clinical Trial Service and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom. FAU - Villanueva, Cary Amiel G AU - Villanueva CAG AD - Division of Pulmonary Medicine, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Villafuerte, Andrew Rufino C AU - Villafuerte ARC AD - Department of Medicine, University of the Philippines Manila, Manila, Philippines. FAU - Cerrado, Johannes Paolo B AU - Cerrado JPB AD - Policy and Practice Research Group, Pandemic Sciences Institute, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom. FAU - Cruz, Marie Gene D AU - Cruz MGD AD - Department of Medicine, University of the Philippines Manila, Manila, Philippines. FAU - De Castro, Lea Roselle O AU - De Castro LRO AD - Department of Medicine, University of the Philippines Manila, Manila, Philippines. FAU - Sucaldito, Ma Sergia Fatima C AU - Sucaldito MSFC AD - Department of Medicine, University of the Philippines Manila, Manila, Philippines. FAU - Yoshida, Alfonso Syoei R AU - Yoshida ASR AD - AMOSUP Seamen's Hospital - Manila, Manila, Philippines. FAU - Geroy, Lester Sam A AU - Geroy LSA AD - Philippine Society of Public Health Physicians (PSPHP), Inc., Paranaque City, Philippines. FAU - Estrada, Elvie Udaundo AU - Estrada EU AD - Integrated Midwives Association of the Philippines, Pangasinan, Philippines. FAU - Garcia, Daisy Evangeline C AU - Garcia DEC AD - Ilocos Training and Regional Medical Center, La Union, Philippines. FAU - Sta Ana, Ferdinand B AU - Sta Ana FB AD - Municipal Health Office, Narra, Palawan, Philippines. FAU - Elises-Molon, Kristine Therese R AU - Elises-Molon KTR AD - Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Silverio-Fernando, Karla Kristine AU - Silverio-Fernando KK AD - Manila Doctors Hospital, Manila, Philippines. FAU - Velayo, Clarissa L AU - Velayo CL AD - College of Medicine, University of the Philippines Manila, Manila, Philippines. AD - Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - David-Bustamante, Lara Marie AU - David-Bustamante LM AD - Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Diosana, Jo-Ann L AU - Diosana JL AD - Action for Economic Reforms (AER), Quezon City, Philippines. FAU - Silvestre, Maria Asuncion A AU - Silvestre MAA AD - Kalusugan ng Mag-Ina, Inc., (KMI), Quezon City, Philippines. FAU - Infantado-Alejandro, Myzelle Anne J AU - Infantado-Alejandro MAJ AD - Department of Medicine, University of the Philippines Manila, Manila, Philippines. AD - De La Salle Medical and Health Sciences Institute, Dasmarinas City, Cavite, Philippines. CN - Philippine Periodic Health Examination Task Force on Prenatal Disorders LA - eng PT - Journal Article DEP - 20260530 PL - Philippines TA - Acta Med Philipp JT - Acta medica Philippina JID - 0312677 PMC - PMC13316254 OTO - NOTNLM OT - antenatal care OT - maternal health OT - neonatal health OT - prenatal clinical practice guidelines OT - screening COIS- All authors declared no conflicts of interest. EDAT- 2026/07/01 06:33 MHDA- 2026/07/01 06:34 PMCR- 2026/05/30 CRDT- 2026/07/01 05:18 PHST- 2026/07/01 06:34 [medline] PHST- 2026/07/01 06:33 [pubmed] PHST- 2026/07/01 05:18 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - AMP-60-10-13595 [pii] AID - 10.47895/amp.v60i10.13595 [doi] PST - epublish SO - Acta Med Philipp. 2026 May 30;60(10):210-227. doi: 10.47895/amp.v60i10.13595. eCollection 2026. PMID- 42382929 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 2094-9278 (Electronic) IS - 0001-6071 (Print) IS - 0001-6071 (Linking) VI - 60 IP - 10 DP - 2026 TI - 2021 Clinical Practice Guidelines on Periodic Health Examination. PG - 7-27 LID - 10.47895/amp.v60i10.12061 [doi] AB - BACKGROUND AND OBJECTIVE: The first Philippine Guidelines on Periodic Health Examination (PHEX) provided evidence-based recommendations for prevention strategies in the Philippines, published in 2004. This 2021 clinical practice guideline (CPG) on PHEX aimed to update the previous PHEX recommendations to align with the implementation of the Universal Health Care Act. This CPG aimed to guide primary care providers, specialists, patients, and the general public and provide recommendations for safe, accessible, and cost-effective screening practices. METHODS: We followed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach, including the GRADE Adolopment and Evidence-to-Decision framework (EtD). A multisectoral panel developed the recommendations by a formal consensus method upon evaluation of the evidence on benefits and harms, cost-effectiveness, patient values and preferences, acceptability, feasibility, and impact on equity. A conflicts of interest (COI) committee reviewed, evaluated, and managed the potential or declared conflicts of interest of this CPG's Task Force members. RESULTS: The 2020 PHEX CPG had 23 recommendation statements. Strong recommendations were made to screen for the following conditions 1) Hypertension, 2) Type 2 Diabetes Mellitus using fasting blood sugar, 3) Adult obesity using Body Mass Index (BMI), 4) Unhealthy alcohol use in adults, 5) Tobacco smoking, 6) Colorectal cancer, and 7) Cervical cancer.Weak recommendations were developed to screen for the following: 1) Lipid disorder among adults with cardiovascular risk factors, 2) Type 2 DM using HBA1C, 3) Acute malnutrition in children, 4) Unhealthy alcohol use in adolescents, 5) High-risk sexual behavior, 6) Depression, and 7) Pulmonary Tuberculosis using chest X-ray.On the other hand, strong recommendations were also made AGAINST screening for the following: 1) Developmental delay using developmental screening tools, 2) Coronary artery disease using ECG, and 3) Chronic Kidney Disease (CKD) using serum creatinine.Weak recommendations were also formulated AGAINST screening for the following: 1) Anemia using hemoglobin and/or hematocrit, 2) CKD using urinalysis, and 3) Lung cancer using chest X-ray. CONCLUSION: This guideline encourages adherence without restricting clinical judgment or patient-specific considerations. It also informs payers and policymakers without serving as the sole basis for financial or legal decisions. The strong recommendations in this CPG can be used as quality-of-care indicators when evaluating primary care programs. The recommendation statements will be updated at least every three years or as new evidence emerges. CI - (c) 2026 Acta Medica Philippina. FAU - Cabaluna, Ian Theodore G AU - Cabaluna ITG AD - Institute of Clinical Epidemiology, National Institutes of Health, University of the Philippines Manila, Manila, Philippines. FAU - Sulit, Maria Vanessa V AU - Sulit MVV AD - Institute of Clinical Epidemiology, National Institutes of Health, University of the Philippines Manila, Manila, Philippines. FAU - Infantado-Alejandro, Myzelle Anne J AU - Infantado-Alejandro MAJ AD - De La Salle Medical and Health Sciences Institute, Cavite, Philippines. FAU - Bayona, Howell Henrian G AU - Bayona HHG AD - Institute of Clinical Epidemiology, National Institutes of Health, University of the Philippines Manila, Manila, Philippines. FAU - Dans, Leonila F AU - Dans LF AD - Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Manila, Philippines. CN - 2021 Philippine Periodic Health Examination Guideline Task Force LA - eng PT - Journal Article DEP - 20260530 PL - Philippines TA - Acta Med Philipp JT - Acta medica Philippina JID - 0312677 PMC - PMC13316251 OTO - NOTNLM OT - guidelines OT - periodic health examination OT - prevention OT - screening COIS- All authors declared no conflicts of interest. EDAT- 2026/07/01 10:11 MHDA- 2026/07/01 10:12 PMCR- 2026/05/30 CRDT- 2026/07/01 05:18 PHST- 2026/07/01 10:12 [medline] PHST- 2026/07/01 10:11 [pubmed] PHST- 2026/07/01 05:18 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - AMP-60-10-12061 [pii] AID - 10.47895/amp.v60i10.12061 [doi] PST - epublish SO - Acta Med Philipp. 2026 May 30;60(10):7-27. doi: 10.47895/amp.v60i10.12061. eCollection 2026. PMID- 42382928 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 2094-9278 (Electronic) IS - 0001-6071 (Print) IS - 0001-6071 (Linking) VI - 60 IP - 10 DP - 2026 TI - Philippine Clinical Practice Guidelines for Periodic Health Examination: Screening for Renal, Metabolic, Nutritional, and Endocrine Disorders. PG - 196-209 LID - 10.47895/amp.v60i10.11674 [doi] AB - BACKGROUND AND OBJECTIVE: Renal, metabolic, nutritional, and endocrine disorders significantly affect Filipinos due to the resulting mortality, cardiovascular outcomes, and negative impact on quality of life. Screening for these disorders may lead to earlier detection and management of the disease, with subsequent improvement of clinical outcomes if early therapeutic options are available. This must be balanced with potential harms resulting from mislabeling and the adverse effects of treatment. The objective of this clinical practice guideline (CPG) is to provide recommendations to optimize patient care on screening for renal, metabolic, nutritional, and endocrine disorders among asymptomatic, apparently healthy Filipinos. METHODS: We followed the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach to CPG development recommended in the Department of Health Manual. The process included 1) generation of critical questions and critical outcomes, 2) retrieval of current evidence, 3) synthesis and assessment of the evidence base for these critical questions, 4) formulation of draft recommendations, 5) convening of a multisectoral stakeholder panel that evaluated the evidence base and considered feasibility, values, and preferences in formulating recommendations, and 6) planning for dissemination, implementation, impact evaluation, and updating. We performed a systematic synthesis of evidence to address screening for high climacteric syndrome, hypocalcemia or hypercalcemia, prediabetes, chronic kidney disease, hyperuricemia, malnutrition, nutritional anemia, among asymptomatic, apparently healthy adult Filipinos, and sexual maturity among asymptomatic, apparently healthy adolescent Filipinos. RESULTS: After the presentation of the evidence synthesis and deliberation of the consensus panelists, this CPG provides 18 recommendation statements for the eight conditions. These statement recommendations serve as guides for the primary care physicians in their screening for the identified renal, metabolic, nutritional, and endocrine disorders. The CPG recommends AGAINST screening for high climacteric syndrome among asymptomatic, apparently healthy women aged 45-55 years using hormonal tests. Moreover, the guideline DOES NOT recommend the use of serum calcium, electrocardiogram, or bone mineral density in screening for hypocalcemia or hypercalcemia; estimated glomerular filtration rate, urine albumin concentration, urine albumin-creatinine ratio, and kidney ultrasonography in screening for chronic kidney disease; mid-upper arm circumference in screening for malnutrition; and, serum uric acid in screening for hyperuricemia for apparently healthy, asymptomatic adults. Routine assessment for sexual maturity among asymptomatic adolescents is also NOT recommended. However, the guideline recommends using fasting plasma glucose and hemoglobin A1C in screening for prediabetes and type 2 diabetes mellitus; waist circumference, waist-hip ratio, and body mass index in screening for malnutrition; and hemoglobin and red blood cell parameters in screening for nutritional anemia. CONCLUSION: The CPG for the Periodic Health Examination, a joint project of the Department of Health and the National Institutes of Health, addressed selected renal, metabolic, nutritional, and endocrine conditions and provided recommendations for their screening. The statements are made to guide the primary care physicians in the screening of identified renal, metabolic, nutritional, and endocrine disorders. These recommendations will be updated after three years or until new evidence arises. CI - (c) 2026 Acta Medica Philippina. FAU - Paz-Pacheco, Elizabeth AU - Paz-Pacheco E AD - Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Oliva, Raymond V AU - Oliva RV AD - Division of Hypertension, Department of Medicine, Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Acuin, Cecilia S AU - Acuin CS AD - Institute of Human Nutrition and Food, University of the Philippines Los Banos, Laguna, Philippines. FAU - Tan, Rey Jaime M AU - Tan RJM AD - Philippine General Hospital, University of the Philippines Manila, Manila, Philippines. FAU - Sarsagat, Jim Paulo D AU - Sarsagat JPD AD - Allied Care Experts Medical Center Palawan, Palawan, Philippines. CN - Philippine Periodic Health Examination Task Force on Screening for Renal, Metabolic, Nutrition, and Endocrine Disorders LA - eng PT - Journal Article DEP - 20260530 PL - Philippines TA - Acta Med Philipp JT - Acta medica Philippina JID - 0312677 PMC - PMC13316249 OTO - NOTNLM OT - anemia OT - chronic kidney diseases OT - climacteric OT - guidelines OT - hypercalcemia OT - hyperuricemia OT - hypocalcemia OT - malnutrition OT - menopause OT - obesity OT - prediabetes OT - sexual maturation COIS- All authors declared no conflicts of interest. EDAT- 2026/07/01 06:33 MHDA- 2026/07/01 06:34 PMCR- 2026/05/30 CRDT- 2026/07/01 05:18 PHST- 2026/07/01 06:34 [medline] PHST- 2026/07/01 06:33 [pubmed] PHST- 2026/07/01 05:18 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - AMP-60-10-11674 [pii] AID - 10.47895/amp.v60i10.11674 [doi] PST - epublish SO - Acta Med Philipp. 2026 May 30;60(10):196-209. doi: 10.47895/amp.v60i10.11674. eCollection 2026. PMID- 42382901 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 5 DP - 2026 May TI - Development of a Nomogram for Peak Nasal Inspiratory Flow Among Indian Children: A Hospital-Based Observational Study. PG - e109948 LID - 10.7759/cureus.109948 [doi] LID - e109948 AB - OBJECTIVE: This study aimed to develop a nomogram for the peak nasal inspiratory flow (PNIF) meter among Indian children and to determine the cutoff value of peak nasal inspiratory flow to detect allergic rhinitis and the blocker variety, as well as to look for differences in PNIF value among age groups. METHODS: A cross-sectional study was conducted in the pediatric outpatient department of a tertiary hospital among children aged six to 17 years. The PNIF data were obtained along with demographic variables. Children were diagnosed with allergic rhinitis, with or without blockage symptoms, according to the Allergic Rhinitis and its Impact on Asthma (ARIA) classification. A total of 573 children were included after applying the exclusion criteria. Data analysis was done using SPSS Statistics version 25 (IBM Corp., Armonk, NY, USA) and Dxt version 1.0 (Biostatistics Resource and Training Centre, Christian Medical College Vellore, TN, IND). RESULTS: The mean PNIF value of all age groups was 67.95 L/min (standard deviation 13.46). The PNIF has a statistically significant but weak correlation with age and a statistically significant difference between age groups. Cutoff values for both allergic rhinitis and blocker varieties were 65 L/min, with varying sensitivity and specificity across age groups. Multiple linear regression analysis derived the equation for PNIF = 53.061 + (1.689 x age) + (1.312 x gender) + (-0.015 x BMI). CONCLUSION: The PNIF with set cutoff values can be used to diagnose allergic rhinitis and the blocker variety in Indian children. It can be used as a diagnostic tool to determine allergic rhinitis with modest diagnostic accuracy in the six to nine-year and 13 to 17-year age groups. For children more than 10 years of age, PNIF demonstrates clinical utility in determining the obstructive nasal phenotype. CI - Copyright (c) 2026, Mitra et al. FAU - Mitra, Samya AU - Mitra S AD - Pediatrics, All India Institute of Medical Sciences (AIIMS), Kalyani, IND. FAU - Mishra, Nihar R AU - Mishra NR AD - Pediatrics, All India Institute of Medical Sciences (AIIMS), Kalyani, IND. FAU - Singh, Ritesh AU - Singh R AD - Community and Family Medicine, All India Institute of Medical Sciences (AIIMS), Kalyani, IND. FAU - Sarkar, Subhankar AU - Sarkar S AD - Pediatrics, All India Institute of Medical Sciences (AIIMS), Kalyani, IND. FAU - Das, Aditi AU - Das A AD - Pediatrics, All India Institute of Medical Sciences (AIIMS), Kalyani, IND. FAU - Bhunia, Niladri S AU - Bhunia NS AD - Pediatrics, All India Institute of Medical Sciences (AIIMS), Kalyani, IND. FAU - Bhowmick, Rohit AU - Bhowmick R AD - Pediatric Critical Care Medicine, All India Institute of Medical Sciences (AIIMS), Kalyani, IND. FAU - Sonowal, Rimjhim AU - Sonowal R AD - Pediatrics, All India Institute of Medical Sciences (AIIMS), Kalyani, IND. LA - eng PT - Journal Article DEP - 20260530 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13315212 OTO - NOTNLM OT - allergic rhinitis OT - clinical nomogram OT - indian children OT - peak nasal inspiratory flow OT - pediatric allergy COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee of All India Institute of Medical Sciences (AIIMS), Kalyani issued approval IEC/AIIMS/Kalyani/Meeting/2023/096. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/07/01 10:11 MHDA- 2026/07/01 10:12 PMCR- 2026/05/30 CRDT- 2026/07/01 05:18 PHST- 2026/05/30 00:00 [accepted] PHST- 2026/07/01 10:12 [medline] PHST- 2026/07/01 10:11 [pubmed] PHST- 2026/07/01 05:18 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - 10.7759/cureus.109948 [doi] PST - epublish SO - Cureus. 2026 May 30;18(5):e109948. doi: 10.7759/cureus.109948. eCollection 2026 May. PMID- 42382799 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 2590-1575 (Electronic) IS - 2590-1575 (Linking) VI - 37 DP - 2026 Jul TI - Simultaneous determination of vitamin A and E in infant formula using a modified QuEChERS approach coupled with ultrahigh-performance liquid chromatography-diode array detection. PG - 104131 LID - 10.1016/j.fochx.2026.104131 [doi] LID - 104131 AB - The simultaneous determination of vitamin A and E vitamers in complex matrices presents a significant analytical challenge. To address this, we validated a straightforward method based on a QuEChERS pretreatment coupled with ultrahigh-performance liquid chromatography and diode array detection (QuEChERS-UPLC-DAD). The modified QuEChERS pretreatment procedure integrates saponification and extraction processes into a single step, enabling efficient phase separation, reducing analysis time, and eliminating the need for a salting-out step. Notably, this approach simultaneously accomplishes a recovery of 83.2% to 100.5%, a relative standard deviation of less than 4.6%. The accuracy of the proposed QuEChERS-UPLC-DAD method was confirmed through comparison with a UPLC-IDMS/MS method and analysis of a commercial certified reference material (NIST SRM 1869). Importantly, the approach was successfully applied to analyze various complex dairy products, including infant formula, milk, yogurt, and dairy beverages. Therefore, QuEChERS-UPLC-DAD approach is well-suited for routine quality control and nutritional assessment. CI - (c) 2026 The Authors. FAU - Zhao, Xiaotong AU - Zhao X AD - Food Safety Analysis Laboratory, Division of Chemical Metrology and Analytical Science, Key Laboratory of Chemical Metrology and Applications on Nutrition and Health for State Market Regulation, National Institute of Metrology, Beijing 100029, PR China. AD - College of Chemistry, State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China. FAU - Li, Xiaomin AU - Li X AD - Food Safety Analysis Laboratory, Division of Chemical Metrology and Analytical Science, Key Laboratory of Chemical Metrology and Applications on Nutrition and Health for State Market Regulation, National Institute of Metrology, Beijing 100029, PR China. FAU - Luo, Shuangxia AU - Luo S AD - Food Safety Analysis Laboratory, Division of Chemical Metrology and Analytical Science, Key Laboratory of Chemical Metrology and Applications on Nutrition and Health for State Market Regulation, National Institute of Metrology, Beijing 100029, PR China. AD - College of Chemistry, State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China. FAU - Zhang, Xuanping AU - Zhang X AD - Food Safety Analysis Laboratory, Division of Chemical Metrology and Analytical Science, Key Laboratory of Chemical Metrology and Applications on Nutrition and Health for State Market Regulation, National Institute of Metrology, Beijing 100029, PR China. AD - College of Chemistry, State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China. FAU - Zhang, Qinghe AU - Zhang Q AD - Food Safety Analysis Laboratory, Division of Chemical Metrology and Analytical Science, Key Laboratory of Chemical Metrology and Applications on Nutrition and Health for State Market Regulation, National Institute of Metrology, Beijing 100029, PR China. FAU - Li, Xiuqin AU - Li X AD - Food Safety Analysis Laboratory, Division of Chemical Metrology and Analytical Science, Key Laboratory of Chemical Metrology and Applications on Nutrition and Health for State Market Regulation, National Institute of Metrology, Beijing 100029, PR China. FAU - Yin, Xiong AU - Yin X AD - College of Chemistry, State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, PR China. LA - eng PT - Journal Article DEP - 20260623 PL - Netherlands TA - Food Chem X JT - Food chemistry: X JID - 101751436 PMC - PMC13316758 OTO - NOTNLM OT - Certified reference material OT - Commercial samples OT - Infant formula OT - QuEChERS-UPLC-DAD OT - Vitamers COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/01 06:34 MHDA- 2026/07/01 06:35 PMCR- 2026/06/23 CRDT- 2026/07/01 05:17 PHST- 2026/03/22 00:00 [received] PHST- 2026/06/17 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/07/01 06:35 [medline] PHST- 2026/07/01 06:34 [pubmed] PHST- 2026/07/01 05:17 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - S2590-1575(26)00652-8 [pii] AID - 104131 [pii] AID - 10.1016/j.fochx.2026.104131 [doi] PST - epublish SO - Food Chem X. 2026 Jun 23;37:104131. doi: 10.1016/j.fochx.2026.104131. eCollection 2026 Jul. PMID- 42382175 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 1663-9812 (Print) IS - 1663-9812 (Electronic) IS - 1663-9812 (Linking) VI - 17 DP - 2026 TI - Pharmacogenomic impact and genetic architecture of toxicity in pediatric acute lymphoblastic leukemia induction therapy: an exploratory modeling approach. PG - 1830183 LID - 10.3389/fphar.2026.1830183 [doi] LID - 1830183 AB - Induction chemotherapy for pediatric Acute Lymphoblastic Leukemia (ALL) is highly curative but accompanied by a severe toxicity profile. Evaluating the genetic susceptibility to these adverse events could inform hypothesis-generating risk stratification. In this exploratory retrospective cohort study (N = 178), we investigated the influence of 14 candidate pharmacogenetic variants on the development of prevalent Adverse Drug Reactions (ADRs, >/= 10 events). Multiple logistic regression, adjusted for basic demographic and anthropometric covariates (age and body surface area), was utilized across comprehensive inheritance architectures (additive, dominant, recessive, and co-dominant). For clinical translation hypothesis generation, we applied LASSO-penalized logistic regression (alpha = 1), 10-fold cross-validation to derive parsimonious Pharmacogenetic Risk Scores (PGRS). Model performance was evaluated using the optimism-corrected Area Under the Receiver Operating Characteristic Curve (AUC) via 1000-iteration bootstrap resampling, and calibration was assessed via the Brier score. We observed several complex interactions, notably suggesting an increased risk of severe neutropenia in patients carrying a homozygous variant CYP3A5 rs776746 genotype (nominally significant OR 5.58, p = 0.006) and a potential pleiotropic protective effect from NFATC2 rs6021191 (OR 0.09, p = 0.001). Penalized selection allowed the construction of compact, multi-locus mathematical risk scores that demonstrated promising diagnostic discrimination for Neutropenia (optimism-corrected AUC 0.793, 95% CI 0.72-0.85; Brier score 0.12), while displaying limited to moderate performance for other clinically discriminating toxicities like Infection (AUC 0.650) and Gastrointestinal complications (AUC 0.607). The primary contribution of this study is the prioritization of pharmacogenomic candidate signals rather than the proposal of models ready for clinical intervention. The integration of alternative genotype parameterizations and regularized machine learning highlights pathways for future predictive research. However, given the retrospective nature of the study and inherent risks of internal optimism, these scores serve as biologically informed proof-of-concept models that strictly require robust prospective external validation. CI - Copyright (c) 2026 Gutierrez-Caceres, Alarcon-Concha, Aracena-Farias, Torres, Acuna, Sandoval, Silva, Ormeno, Oyarce, Cerpa and Martinez. FAU - Gutierrez-Caceres, Carolina AU - Gutierrez-Caceres C AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. AD - Faculty of Pharmacy, University of Concepcion, Concepcion, Chile. FAU - Alarcon-Concha, Claudio AU - Alarcon-Concha C AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. AD - Laboratory of Chemical Carcinogenesis and Pharmacogenetics (CQF), Department of Basic and Clinical Oncology, Faculty of Medicine, University of Chile, Santiago, Chile. FAU - Aracena-Farias, Javiera AU - Aracena-Farias J AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. FAU - Torres, Esperanza AU - Torres E AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. FAU - Acuna, Ivan AU - Acuna I AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. FAU - Sandoval, Tamara AU - Sandoval T AD - Faculty of Pharmacy, University of Concepcion, Concepcion, Chile. FAU - Silva, Pamela AU - Silva P AD - Hospital de Ninos Roberto del Rio, Santiago, Chile. FAU - Ormeno, Maricruz AU - Ormeno M AD - Hospital Luis Calvo Mackenna, Santiago, Chile. FAU - Oyarce, Veronica AU - Oyarce V AD - Hospital Exequiel Gonzalez Cortes, Santiago, Chile. AD - Centro de Investigacion Clinica Avanzada (CICA) Hospital Exequiel Gonzalez Cortes - Facultad de Medicina Universidad de Chile, Santiago, Chile. FAU - Cerpa, Leslie C AU - Cerpa LC AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. AD - Laboratory of Chemical Carcinogenesis and Pharmacogenetics (CQF), Department of Basic and Clinical Oncology, Faculty of Medicine, University of Chile, Santiago, Chile. AD - Center for Cancer Prevention and Control (CECAN), Santiago, Chile. AD - Latin American Network for Implementation and Validation of Clinical Pharmacogenomics Guidelines (RELIVAF-CYTED), Santiago, Chile. FAU - Martinez, Matias F AU - Martinez MF AD - Laboratory of Advanced Research in Personalized Medicine, Department of Pharmaceutical Sciences and Technology, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, Santiago, Chile. AD - Centro de Investigacion Clinica Avanzada (CICA) Hospital Exequiel Gonzalez Cortes - Facultad de Medicina Universidad de Chile, Santiago, Chile. AD - Latin American Network for Implementation and Validation of Clinical Pharmacogenomics Guidelines (RELIVAF-CYTED), Santiago, Chile. LA - eng PT - Journal Article DEP - 20260616 PL - Switzerland TA - Front Pharmacol JT - Frontiers in pharmacology JID - 101548923 PMC - PMC13314868 OTO - NOTNLM OT - acute lymphoblastic leukemia OT - adverse drug reaction OT - pediatric oncohematology OT - pharmacogenomics OT - polygenic risk score (PGRS) OT - precision medicine COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/07/01 10:11 MHDA- 2026/07/01 10:12 PMCR- 2026/06/16 CRDT- 2026/07/01 05:09 PHST- 2026/03/13 00:00 [received] PHST- 2026/05/12 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/07/01 10:12 [medline] PHST- 2026/07/01 10:11 [pubmed] PHST- 2026/07/01 05:09 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 1830183 [pii] AID - 10.3389/fphar.2026.1830183 [doi] PST - epublish SO - Front Pharmacol. 2026 Jun 16;17:1830183. doi: 10.3389/fphar.2026.1830183. eCollection 2026. PMID- 42382020 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 0915-5287 (Print) IS - 2187-5626 (Electronic) IS - 0915-5287 (Linking) VI - 38 IP - 7 DP - 2026 Jul TI - Design and development of a universal OMNI exertion faces scale. PG - 324-329 LID - 10.1589/jpts.38.324 [doi] AB - [Purpose] To design and develop a new OMNI Exertion Faces Scale (OMNI Faces) that uses universal design criteria to improve acceptability for measuring perceived exertion across age groups, physical activities, and clinical populations. [Methods] The OMNI Faces Scale was developed in collaboration with the original OMNI creator and refined through consultations with educators, speech-language pathologists, clinicians, and feedback from children and adults. Design considerations included universal accessibility, simplified instructions, and alignment with the Heart Rate Reserve method. [Design Features] The OMNI Faces Scale includes five verbal descriptors and five pictorial images to reduce inconsistencies with language, activity-specific visuals, and anchoring among prior versions. The OMNI Faces Scale is non-gendered, non-activity-specific, and has accessible fonts. Instructions were simplified to 71 words relevant for assessing perceived exertion during both aerobic and resistance activities. [Conclusions] The OMNI Faces Scale was designed to provide a versatile and inclusive tool for monitoring exertion in children and adults across a broad range of physical activity applications. Future research will validate its psychometric properties across populations and activity types and explore multilingual adaptations. CI - 2026(c)by the Society of Physical Therapy Science. Published by IPEC Inc. FAU - Schlessman, Amy AU - Schlessman A AD - Department of Rehabilitation Sciences, School of Medicine, Tufts University: 145 Harrison Avenue Boston, MA, USA. FAU - Wickstrom, Rick AU - Wickstrom R AD - Workability Systems, Inc., USA. FAU - Petrosino, Chris AU - Petrosino C AD - Sacred Heart University, USA. FAU - Robertson, Robert AU - Robertson R AD - University of Pittsburgh, USA. LA - eng PT - Journal Article DEP - 20260701 PL - Japan TA - J Phys Ther Sci JT - Journal of physical therapy science JID - 9105359 PMC - PMC13318445 OTO - NOTNLM OT - OMNI Faces Scale OT - Perceived exertion OT - Physical activity COIS- Authors Rick Wickstrom (second author), Amy Schlessman (first author), and Robert Robertson (fourth author) developed the OMNI Exertion Faces Scale. Christopher Petrosino (third author) declares no conflict of interest. This universal design project to develop the OMNI Faces Exertion Scale was Dr. Robertson's last research contribution as a Professor Emeritus at the University of Pittsburgh before he passed away peacefully on November 14, 2025, at age 82. His patience, clarity, and encouragement shaped countless careers of students and colleagues and reflected his lifelong passion for exercise science across the lifespan. EDAT- 2026/07/01 06:34 MHDA- 2026/07/01 06:35 PMCR- 2026/07/01 CRDT- 2026/07/01 05:07 PHST- 2026/01/08 00:00 [received] PHST- 2026/04/17 00:00 [accepted] PHST- 2026/07/01 06:35 [medline] PHST- 2026/07/01 06:34 [pubmed] PHST- 2026/07/01 05:07 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - 2025-152 [pii] AID - 10.1589/jpts.38.324 [doi] PST - ppublish SO - J Phys Ther Sci. 2026 Jul;38(7):324-329. doi: 10.1589/jpts.38.324. Epub 2026 Jul 1. PMID- 42381602 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260828 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 3 DP - 2026 Jul TI - The Expanded Biopsychosocial Model Elucidates the Association Between Pre-Pregnancy Overweight/Obesity and Delayed Lactogenesis II: A Prospective Cohort Study. PG - e70225 LID - 10.1111/mcn.70225 [doi] LID - e70225 AB - Pre-pregnancy overweight or obesity delays the onset of lactogenesis II, posing an early barrier to achieving optimal infant nutrition and long-term health. However, the underlying pathophysiological mechanisms remain incompletely elucidated. This prospective cohort study conducted in China aimed to delineate the distinct pathways through which pre-pregnancy overweight/obesity, compared to normal body mass index (BMI), leads to delayed lactogenesis II. Guided by an expanded biopsychosocial framework, we enrolled and stratified 296 primiparous women into pre-pregnancy overweight/obese (n = 146) and normal BMI (n = 150) groups. Data on biological, psychological, social, and infant-related factors were collected prospectively at prenatal, delivery, and one-week postpartum stages. Structural equation modeling was used to identify and compare the mediating pathways between the two groups. Results demonstrated that the association between pre-pregnancy overweight/obesity and delayed lactogenesis II was primarily mediated through four distinct pathways: biological (e.g., breastfeeding difficulties: beta = 0.203, 95% CI: 0.144-0.265, p < 0.001), psychological (e.g., internalized weight stigma: beta = 0.095, 95% CI: 0.016-0.181, p = 0.026), social (e.g., reduced pro-breastfeeding practices: beta = 0.076, 95% CI: 0.017-0.144, p = 0.019), and infant-related (e.g., higher formula intake: beta = 0.114, 95% CI: 0.047-0.195, p = 0.003). This study validates the expanded biopsychosocial model by elucidating the distinct pathways through which pre-pregnancy overweight/obesity contributes to delayed lactogenesis II. These findings underscore the necessity for clinical practice to move beyond a purely biological focus and advocate for a paradigm shift in clinical support towards integrated, multi-faceted interventions tailored to this vulnerable population. TRIAL REGISTRATION: This study was registered at the Chinese Clinical Trial Registry (registry number: ChiCTR2200057038). The trial was registered on February 26, 2022. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Ren, Ziqi AU - Ren Z AUID- ORCID: 0000-0002-5285-5794 AD - School of Nursing, Nanjing Medical University, Nanjing, Jiangning District, China. FAU - Zhang, Aixia AU - Zhang A AUID- ORCID: 0000-0002-1266-0925 AD - Department of Nursing, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, Qinhuai District, China. FAU - Zhang, Jingjing AU - Zhang J AD - Department of Nursing, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, Qinhuai District, China. FAU - Fan, Xuemei AU - Fan X AD - Department of Nursing, Women's Hospital of Nanjing Medical University (Nanjing Women and Children's Healthcare Hospital), Nanjing, Qinhuai District, China. FAU - Tang, Huiting AU - Tang H AD - School of Nursing, Nanjing Medical University, Nanjing, Jiangning District, China. LA - eng GR - 72204123/National Natural Science Foundation of China Youth Program/ GR - FNF202102/Nursing Scientific Research at Fudan University/ GR - Jiangsu Education Departmentleft broken bracket2023right broken bracketNo.11/Project of "Nursing Science" Funded by the 4th Priority Discipline Development Program of Jiangsu Higher Education Institutions/ PT - Journal Article PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Female MH - Prospective Studies MH - Pregnancy MH - Adult MH - *Overweight/physiopathology MH - *Lactation/physiology/psychology MH - Breast Feeding/psychology/statistics & numerical data MH - *Obesity/physiopathology MH - China/epidemiology MH - Body Mass Index MH - *Pregnancy Complications MH - Infant, Newborn PMC - PMC13320373 OTO - NOTNLM OT - biopsychosocial model OT - breastfeeding OT - lactogenesis II OT - maternity care OT - mechanisms OT - mediating pathways OT - pre-pregnancy obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/07/01 06:33 MHDA- 2026/07/01 16:11 PMCR- 2026/07/01 CRDT- 2026/07/01 04:53 PHST- 2026/04/07 00:00 [revised] PHST- 2025/12/11 00:00 [received] PHST- 2026/06/13 00:00 [accepted] PHST- 2026/07/01 16:11 [medline] PHST- 2026/07/01 06:33 [pubmed] PHST- 2026/07/01 04:53 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - MCN70225 [pii] AID - 10.1111/mcn.70225 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jul;22(3):e70225. doi: 10.1111/mcn.70225. PMID- 42381598 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260828 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 3 DP - 2026 Jul TI - Potential Donors' Awareness and Perceived Feasibility of Donating Human Milk in Australia. PG - e70224 LID - 10.1111/mcn.70224 [doi] LID - e70224 AB - Human milk banks rely on voluntary donations from lactating individuals producing more milk than their baby needs, to make pasteurised donor human milk (PDHM) for preterm babies. Demand for PDHM is increasing, as is the need for donors. Few Australian studies have explored potential donors' awareness and perceived feasibility of donating to a milk bank. We aimed to survey women breastfeeding their own child (< 24 months) or pregnant (and intending to breastfeed), and residing in major metropolitan areas of Australia, to determine their awareness of milk banks, and interest in and perceived feasibility (ease, eligibility) of donating to a milk bank. 1221 participants completed the survey (112 pregnant women, 1109 breastfeeding women). Most (78%) had heard of milk banks, and 81.7% lived in an area eligible to donate to a milk bank, yet only 11% were aware of a milk bank in their area. Most (60%) pregnant women would prefer to use online sources or health professionals to find information about donation. Most breastfeeding women (77%) were interested in donating milk, however only 26% thought it would be easy to meet milk bank requirements, and that they would be eligible to donate. Barriers to donating for breastfeeding women involved having no excess milk to donate, lack of time to express/donate, and lack of space to store milk. Awareness raising of local milk banks, promotion of donation information amongst healthcare professionals, and modifications to improve feasibility of donation will likely engage new potential donors and ensure sustainability of milk banks. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Hyde, Melissa K AU - Hyde MK AUID- ORCID: 0000-0001-9616-2028 AD - School of Psychology, The University of Queensland, Brisbane, Queensland, Australia. AD - Strategic Transformation & Readiness, Australian Red Cross Lifeblood, Melbourne, Victoria, Australia. FAU - Newman, Claire AU - Newman C AUID- ORCID: 0000-0001-7614-931X AD - Strategy and Growth, Australian Red Cross Lifeblood, Alexandria, New South Wales, Australia. FAU - Edwards, Abigail R-A AU - Edwards AR AUID- ORCID: 0000-0002-1169-1738 AD - School of Psychology, The University of Queensland, Brisbane, Queensland, Australia. AD - Strategic Transformation & Readiness, Australian Red Cross Lifeblood, Melbourne, Victoria, Australia. FAU - Clifford, Vanessa AU - Clifford V AUID- ORCID: 0000-0001-9758-867X AD - Strategy and Growth, Australian Red Cross Lifeblood, Alexandria, New South Wales, Australia. AD - Murdoch Children's Research Institute, Parkville, Victoria, Australia. AD - Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia. FAU - Masser, Barbara M AU - Masser BM AUID- ORCID: 0000-0001-9385-6497 AD - School of Psychology, The University of Queensland, Brisbane, Queensland, Australia. AD - Strategic Transformation & Readiness, Australian Red Cross Lifeblood, Melbourne, Victoria, Australia. AD - Department of Public Health and Primary Care, National Institute for Health and Care Research Blood and Transplant Research Unit in Donor Health and Behaviour, University of Cambridge, Cambridge, England, UK. FAU - Klein, Laura D AU - Klein LD AUID- ORCID: 0000-0002-7287-8029 AD - Strategy and Growth, Australian Red Cross Lifeblood, Alexandria, New South Wales, Australia. LA - eng GR - #2024589/National Health and Medical Research Council/ GR - GO6587/Australian Government Department of Health, Disability and Ageing/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Female MH - *Milk Banks/statistics & numerical data MH - Australia MH - *Milk, Human MH - Adult MH - *Tissue Donors/psychology MH - Breast Feeding MH - *Health Knowledge, Attitudes, Practice MH - Pregnancy MH - Surveys and Questionnaires MH - Infant, Newborn MH - Young Adult MH - Feasibility Studies MH - Awareness MH - Infant PMC - PMC13320368 OTO - NOTNLM OT - attitudes OT - awareness OT - breastfeeding OT - human milk OT - milk banks OT - potential donors COIS- MKH, CN, AE, VC, BMM, and LDK are current or former employees or affiliates of Australian Red Cross Lifeblood, which provides pasteurised donor human milk to hospitals in Australia. The authors do not have any other conflicts of interest to declare. EDAT- 2026/07/01 06:33 MHDA- 2026/07/01 18:33 PMCR- 2026/07/01 CRDT- 2026/07/01 04:53 PHST- 2026/05/10 00:00 [revised] PHST- 2025/07/30 00:00 [received] PHST- 2026/06/13 00:00 [accepted] PHST- 2026/07/01 18:33 [medline] PHST- 2026/07/01 06:33 [pubmed] PHST- 2026/07/01 04:53 [entrez] PHST- 2026/07/01 00:00 [pmc-release] AID - MCN70224 [pii] AID - 10.1111/mcn.70224 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jul;22(3):e70224. doi: 10.1111/mcn.70224. PMID- 42381294 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260701 LR - 20260813 IS - 1308-8734 (Print) IS - 1308-8742 (Electronic) IS - 1308-8734 (Linking) VI - 58 IP - 4 DP - 2026 Jun 15 TI - Peripheral Nitrosative Stress in Pediatric Anxiety Disorders: Elevated Serum Nitric Oxide Levels. PG - 1-6 LID - 10.5152/eurasianjmed.2026.251235 [doi] LID - e251235 AB - BACKGROUND: The developing pediatric brain is vulnerable to nitrosative stress. This study investigated serum nitric oxide (NO), inducible nitric oxide synthase (iNOS), and S-nitrosothiols (SNOs) as peripheral biomarkers in children with anxiety disorders (ADs) and their associations with symptom severity. METHODS: Eighty-one participants aged 7-17 years were enrolled, including 40 drug-naive participants with ADs and 41 age- and sex-matched healthy controls (HCs). Diagnoses were established using the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version, DSM-5- Turkish version (K-SADS-PL-DSM-5-T). Symptom severity was assessed using the Screen for Child Anxiety Related Emotional Disorders (SCARED) and the Clinical Global Impression-Severity (CGI-S) Scale. Data were analyzed using between-group comparisons, correlation analyses, covariance analyses (MANCOVA/ ANCOVA), controlling for age, sex, and body mass index (BMI), and receiver operating characteristic (ROC) analysis. RESULTS: Serum NO levels were significantly higher in the AD group compared with HCs (P = .028), whereas iNOS and SNO levels did not differ (P > .05). In adjusted analyses controlling for age, sex, and BMI, NO remained significantly higher, and iNOS and SNO levels were also significantly higher in the AD group. No marker (NO, iNOS, SNOs) correlated significantly with anxiety severity (all P > .05). Receiver operating characteristic analysis indicated modest diagnostic accuracy for NO (area under the curve (AUC) = 0.629, 95% CI: 0.506-0.752, P = .046), while iNOS and SNOs were not significant. CONCLUSION: Elevated NO, alongside adjusted increases in iNOS and SNO, supports altered peripheral nitrosative signaling in pediatric ADs. Nitric oxide showed modest discriminative value. Cite this article as: Okuyucu M, Ceylan MF, Hesapcioglu ST, Kafali S, Neselioglu S, Erel O. Peripheral nitrosative stress in pediatric anxiety disorders: elevated serum nitric oxide levels. Eurasian J Med. 2026, 58(4), 1235, doi:10.5152/eurasianjmed.2026.251235. FAU - Okuyucu, Merve AU - Okuyucu M AD - Department of Child and Adolescent Psychiatry, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkiye. FAU - Ceylan, Mehmet Fatih AU - Ceylan MF AD - Department of Child and Adolescent Psychiatry, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, Turkiye. FAU - Hesapcioglu, Selma Tural AU - Hesapcioglu ST AD - Department of Child and Adolescent Psychiatry, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, Turkiye. FAU - Kafali, Seda AU - Kafali S AD - Department of Child and Adolescent Psychiatry, Kirikkale Yuksek Ihtisas Hospital, Kirikkale, Turkiye. FAU - Neselioglu, Salim AU - Neselioglu S AD - Department of Biochemistry, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, Turkiye. FAU - Erel, Ozcan AU - Erel O AD - Department of Biochemistry, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260615 PL - Turkey TA - Eurasian J Med JT - The Eurasian journal of medicine JID - 101557701 PMC - PMC13324883 COIS- Declaration of Interests: The authors have no conflicts of interest to declare. EDAT- 2026/07/01 10:11 MHDA- 2026/07/01 10:12 PMCR- 2026/06/15 CRDT- 2026/07/01 01:42 PHST- 2026/06/15 00:00 [received] PHST- 2026/07/01 10:12 [medline] PHST- 2026/07/01 10:11 [pubmed] PHST- 2026/07/01 01:42 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - eajm-58-4-251235 [pii] AID - 10.5152/eurasianjmed.2026.251235 [doi] PST - epublish SO - Eurasian J Med. 2026 Jun 15;58(4):1-6. doi: 10.5152/eurasianjmed.2026.251235. PMID- 42380924 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260925 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 30 TI - Low serum vitamin D levels are associated with neonatal indirect hyperbilirubinemia and prolonged phototherapy duration: a retrospective case-control study. LID - 10.1186/s12887-026-07234-2 [doi] LID - 896 AB - OBJECTIVE: To investigate the association between serum 25-hydroxyvitamin D [25(OH)D] levels, indirect hyperbilirubinemia severity, and phototherapy duration in term neonates. METHODS: This retrospective case-control study included 79 term neonates admitted to a tertiary neonatal intensive care unit between March 2023 and March 2024. Thirty-nine neonates requiring phototherapy for indirect hyperbilirubinemia (case group) were compared with 40 healthy term neonates (control group). Clinical and biochemical parameters, including bilirubin, 25(OH)D, calcium, phosphorus, magnesium, and alkaline phosphatase levels, were evaluated. Correlation, receiver operating characteristic [ROC], and multivariable regression analyses were performed to assess the association between vitamin D status and phototherapy duration in indirect hyperbilirubinemia. RESULTS: Serum 25(OH)D levels were significantly lower in neonates requiring phototherapy, with 75% demonstrating vitamin D deficiency (< 20 ng/mL). Lower vitamin D levels were associated with prolonged phototherapy duration (r = - 0.337, p = 0.036). Although no significant linear correlation was observed between serum 25(OH)D concentration and baseline bilirubin levels, neonates with vitamin D concentrations < 20 ng/mL exhibited significantly higher bilirubin levels than those with concentrations >/= 20 ng/mL. ROC analysis demonstrated moderate predictive performance for prolonged phototherapy duration (AUC = 0.78, 95% CI: 0.67-0.88). The optimal cutoff value was 17.2 ng/mL, yielding a sensitivity of 84% and specificity of 69%. Multivariable regression analysis identified serum vitamin D level and baseline bilirubin concentration as significant predictors of phototherapy duration. CONCLUSION: Lower serum 25(OH)D concentrations were associated with indirect hyperbilirubinemia and prolonged phototherapy duration in term neonates. Larger prospective studies are needed to confirm these findings and clarify their clinical significance. CI - (c) 2026. The Author(s). FAU - Demir, Batuhan Berk AU - Demir BB AUID- ORCID: 0000-0002-0349-5112 AD - Department of Pediatrics, Kutahya City Hospital/Kutahya Health Sciences University, Kutahya, Turkiye. mdbatuhanberkdemir@gmail.com. FAU - Hazer, Ilhan AU - Hazer I AD - Department of Pediatric Endocrinology, Kutahya City Hospital/Kutahya Health Sciences University, Kutahya, Turkiye. FAU - Turkeli, Ahmet AU - Turkeli A AD - Department of Pediatric Allergy and Immunology, Kutahya City Hospital/Kutahya Health Sciences University, Kutahya, Turkiye. LA - eng PT - Journal Article DEP - 20260630 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) RN - RFM9X3LJ49 (Bilirubin) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Retrospective Studies MH - *Phototherapy MH - Case-Control Studies MH - *Vitamin D/blood/analogs & derivatives MH - Infant, Newborn MH - Male MH - *Hyperbilirubinemia, Neonatal/therapy/blood/complications MH - Female MH - *Vitamin D Deficiency/complications/blood MH - ROC Curve MH - Bilirubin/blood MH - Biomarkers/blood PMC - PMC13599256 COIS- Declarations. Ethics approval and consent to participate: This retrospective case-control study was approved by the Kutahya Health Sciences University Non-Interventional Clinical Research Ethics Committee (Decision No: 2024/11-35; Date: 30 September 2024). The study was conducted in accordance with the ethical principles of the Declaration of Helsinki. As the study was retrospective and based on archived hospital records, informed consent was waived by the ethics committee. Competing interests: The authors declare no competing interests. EDAT- 2026/07/01 06:35 MHDA- 2026/09/23 05:35 PMCR- 2026/06/30 CRDT- 2026/07/01 00:41 PHST- 2026/05/01 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/09/23 05:35 [medline] PHST- 2026/07/01 06:35 [pubmed] PHST- 2026/07/01 00:41 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - 10.1186/s12887-026-07234-2 [pii] AID - 7234 [pii] AID - 10.1186/s12887-026-07234-2 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 30;26(1):896. doi: 10.1186/s12887-026-07234-2. PMID- 42380910 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20260920 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 30 TI - Predicting abnormal birth weight and identifying associated factors using machine learning in the Hararghe Health and Demographic Surveillance System, Ethiopia. LID - 10.1186/s12889-026-28135-0 [doi] LID - 2622 AB - BACKGROUND: Birth weight is a reliable indicator of intrauterine growth and an important predictor of neonatal survival, growth, and long-term development. Globally, approximately 15.5% of live births are low birth weight, and nearly 10% are macrosomic (high birth weight), with a substantial proportion of these cases occurring in sub-Saharan Africa. Birth weights outside the normal range of 2,500-4,000 g are considered abnormal and are associated with increased risks of neonatal and maternal complications. Ethiopia is similarly affected by the growing burden of abnormal birth weight. METHODS: A retrospective cross-sectional study design using secondary HDSS data collected from 2015 to 2022 was employed. This design was considered appropriate because the study aimed to develop machine learning models using routinely collected surveillance data to predict abnormal birth weight and identify associated factors, rather than to establish causal relationships. All singleton births were included, and those with missing birth weight data were excluded. Six machine learning algorithms identified from the literature were built and compared to identify the best-performing model for predicting abnormal birth weight. Prior observational studies and expert opinion were used to select the candidate features for all models. The synthetic minority oversampling technique (SMOTE) was used to manage the imbalance in the dataset. The dataset was split into training (80%, n = 9,242) and testing (20%, n = 2,311) subsets for model development and evaluation. Hyper-parametric tuning was performed using grid search combined with 10-fold cross-validation to optimize model performance and reduce over-fitting. Model performance was evaluated using the area under the receiver operating characteristic curve (AUROC), accuracy, precision, F1-score, and Kappa. Feature importance analysis was done using Shapley Additive explanation (SHAP) values. RESULTS: The Descriptive analysis of 11,553 singleton births showed that 10.78% of the newborns had high birth weight (HBW) and 9.28% had low birth weight (LBW). The eXtreme Gradient Boosting (XGBoost) model performed best by achieving an AUC of 0.835, an accuracy of 0.72, a precision of 0.67, an F1-score of 0.63, a recall of 0.54, and a kappa of 0.52 for abnormal birth weight prediction. The feature importance analysis showed that the top predictors for the low birth weight (LBW) include maternal educational status, age at first delivery, and antenatal care (ANC) visit, while high birth weight (HBW) was strongly predicted by antenatal care (ANC) visit, maternal literacy status, age at first delivery, and maternal education. CONCLUSION: Machine learning models showed moderate performance in predicting abnormal birth weight using HDSS surveillance data. Maternal educational characteristics, age at first delivery, and ANC utilization were identified as important predictive features. However, the findings should be interpreted cautiously because the model identified predictive associations rather than causal relationships. Further studies incorporating additional maternal clinical and nutritional variables, as well as external validation datasets, are recommended to improve predictive performance and generalizability. CI - (c) 2026. The Author(s). FAU - Abdeta, Sington AU - Abdeta S AD - College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia. singtonabdeta128@gmail.com. FAU - Diop, Ousmane AU - Diop O AD - The Institute for Health Research, Epidemiological Surveillance and Training (IRESSEF), Dakar, Senegal. FAU - Cygu, Steve AU - Cygu S AD - African Population and Health Research Center (APHRC), Nairobi, Kenya. FAU - Drame, Aboubacry AU - Drame A AD - Ministry of Health, Dakar, Senegal. FAU - Momanyi, Reinpeter AU - Momanyi R AD - African Population and Health Research Center (APHRC), Nairobi, Kenya. FAU - Endalamaw Dejene, Belayneh AU - Endalamaw Dejene B AD - University of Gondar, Gondar, Ethiopia. AD - Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia. FAU - Tadele, Mulugeta AU - Tadele M AD - Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia. FAU - Sintayehu, Yordanos AU - Sintayehu Y AD - Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia. FAU - Barasa, Miranda AU - Barasa M AD - African Population and Health Research Center (APHRC), Nairobi, Kenya. FAU - Woldie, Mirkuzie AU - Woldie M AD - Fenot Associates, Addis Ababa, Ethiopia. FAU - Girma, Tsinuel AU - Girma T AD - Fenot Associates, Addis Ababa, Ethiopia. FAU - Tsegaye, Rosa AU - Tsegaye R AD - Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia. FAU - Kiragga, Agnes AU - Kiragga A AD - African Population and Health Research Center (APHRC), Nairobi, Kenya. FAU - Adnew, Bethlehem AU - Adnew B AD - Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia. FAU - Howe, Rawleigh AU - Howe R AD - Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia. FAU - Dheresa, Merga AU - Dheresa M AD - College of Health and Medical Sciences, Haramaya University, Harar, Ethiopia. FAU - Abdisa, Alemseged AU - Abdisa A AD - Armauer Hansen Research Institute (AHRI), Addis Ababa, Ethiopia. LA - eng PT - Journal Article DEP - 20260630 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Ethiopia/epidemiology MH - Female MH - Retrospective Studies MH - Cross-Sectional Studies MH - Predictive Learning Models MH - *Machine Learning MH - *Birth Weight MH - Infant, Newborn MH - Prediction Algorithms MH - Adult MH - Risk Factors MH - Male MH - Classification Algorithms MH - *Population Surveillance MH - Pregnancy PMC - PMC13587436 OTO - NOTNLM OT - Abnormal birth weight OT - Associated factors OT - Ethiopia OT - Hararghe HDSS OT - Machine learning OT - Prediction COIS- Declarations. Ethics approval and consent to participate: The Hararghe Health and Demographic Surveillance System (HDSS) received ethical approval from the Institutional Review Board (IRB) of Haramaya University. During the original data collection, written informed consent was obtained from all participants aged 18 years and above, as well as from the legal guardians of participants under 18 years. Verbal assent was additionally obtained from children under 18 years. All procedures were conducted in accordance with the Declaration of Helsinki and other relevant guidelines. The Hararghe HDSS coordinator granted permission to access and use the HDSS data for research purposes. To maintain confidentiality, all data were de-identified before analysis, with personal identifiers such as names and child ID removed. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/07/01 06:33 MHDA- 2026/09/18 05:36 PMCR- 2026/06/30 CRDT- 2026/07/01 00:40 PHST- 2026/03/25 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/09/18 05:36 [medline] PHST- 2026/07/01 06:33 [pubmed] PHST- 2026/07/01 00:40 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - 10.1186/s12889-026-28135-0 [pii] AID - 28135 [pii] AID - 10.1186/s12889-026-28135-0 [doi] PST - epublish SO - BMC Public Health. 2026 Jun 30;26(1):2622. doi: 10.1186/s12889-026-28135-0. PMID- 42380694 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260831 IS - 1463-1326 (Electronic) IS - 1462-8902 (Print) IS - 1462-8902 (Linking) VI - 28 IP - 9 DP - 2026 Sep TI - Pubertal Stage-Based One-hour Postload Glucose Thresholds Improve Identification of Prediabetes and Type 2 Diabetes in Children With Overweight or Obesity. PG - 8469-8481 LID - 10.1111/dom.70969 [doi] AB - AIMS: One-hour postload plasma glucose (1h-PG) is an early marker of dysglycemia in adults, but its utility in children and adolescents is uncertain because insulin sensitivity changes during growth and puberty. We aimed to establish age- and pubertal stage-specific 1h-PG thresholds for identifying prediabetes and Type 2 diabetes (T2D) in children with overweight or obesity. MATERIALS AND METHODS: In this cross-sectional study, 4344 children and adolescents with overweight or obesity underwent an oral glucose tolerance test. Participants were classified into four groups: normal glucose tolerance (NGT) with normal 1 h-PG, NGT with elevated 1 h-PG, prediabetes and T2D. Insulin resistance and beta-cell function indices were assessed. Participants were stratified by chronological age and pubertal stage. The optimal 1h-PG cut-offs were obtained via receiver operating characteristic (ROC) and age- and pubertal stage-based thresholds were compared for diagnostic performance. These thresholds were then validated in two independent cohorts. RESULTS: Among individuals with NGT, those with elevated 1h-PG exhibited greater insulin resistance, impaired beta-cell function and a higher insulin area under the curve (29 916 vs. 23 524, p < 0.001). 1 h-PG levels increased with pubertal progression. Pubertal stage-specific thresholds showed superior discrimination compared with age-based stratification and adult cut-offs. Compared with adult thresholds (8.6 mmol/L for prediabetes and 11.6 mmol/L for T2D), a prepubertal cut-off of 7.78 mmol/L improved sensitivity for prediabetes (75.40% vs. 56.68%) and a pubertal cut-off of 10.48 mmol/L improved sensitivity for T2D (89.47% vs. 73.68%). CONCLUSIONS: Elevated 1h-PG proved to be a practical marker for identifying early metabolic dysfunction in children and adolescents with euglycemia. Given that widely used adult-derived cut-offs (8.6 and 11.6 mmol/L) are suboptimal for pediatric populations, we established pubertal stage-specific thresholds that outperformed both age-specific and adult-derived cut-offs. These stage-specific thresholds may serve as an effective screening tool for diabetes risk in children and adolescents with overweight or obesity. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Wu, Zhaoyuan AU - Wu Z AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Li, Yangxi AU - Li Y AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Qin, Zhewen AU - Qin Z AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Liu, Yaru AU - Liu Y AUID- ORCID: 0000-0002-9758-5951 AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Le, Kaixing AU - Le K AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Zhou, Xuelian AU - Zhou X AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Sun, Yan AU - Sun Y AD - Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. FAU - Huang, Ke AU - Huang K AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Wu, Wei AU - Wu W AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Dong, Guanping AU - Dong G AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Fu, Junfen AU - Fu J AUID- ORCID: 0000-0001-6405-1251 AD - Department of Endocrinology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. LA - eng GR - 2023ZD0508200/Noncommunicable Chronic Diseases-National Science and Technology Major Project/ GR - 2023ZD0508204/Noncommunicable Chronic Diseases-National Science and Technology Major Project/ GR - Zhejiang Province Multidisciplinary Innovative Team for the Diagnosis and Treatment of Diabetes with Traditional Chinese Medicine/ GR - YXH2024YS028/2024 Shandong Medical Association Scientific Research Project/ PT - Journal Article DEP - 20260630 PL - England TA - Diabetes Obes Metab JT - Diabetes, obesity & metabolism JID - 100883645 RN - 0 (Blood Glucose) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/diagnosis/blood/complications MH - *Prediabetic State/diagnosis/blood/complications MH - Male MH - Child MH - Female MH - Adolescent MH - Cross-Sectional Studies MH - Glucose Tolerance Test MH - *Puberty/blood MH - *Blood Glucose/metabolism/analysis MH - Insulin Resistance MH - *Pediatric Obesity/complications/blood MH - *Overweight/complications/blood MH - Biomarkers/blood MH - Insulin-Secreting Cells PMC - PMC13448984 OTO - NOTNLM OT - 1-h postprandial plasma glucose OT - Type 2 diabetes OT - children OT - insulin resistance OT - beta cell function COIS- The authors declare no conflicts of interest. EDAT- 2026/07/01 10:11 MHDA- 2026/08/07 12:39 PMCR- 2026/08/07 CRDT- 2026/07/01 00:27 PHST- 2026/05/25 00:00 [revised] PHST- 2026/03/05 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/08/07 12:39 [medline] PHST- 2026/07/01 10:11 [pubmed] PHST- 2026/07/01 00:27 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - DOM70969 [pii] AID - 10.1111/dom.70969 [doi] PST - ppublish SO - Diabetes Obes Metab. 2026 Sep;28(9):8469-8481. doi: 10.1111/dom.70969. Epub 2026 Jun 30. PMID- 42379716 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 6 DP - 2026 Jun 30 TI - Development and internal validation of a neonatal mortality risk prediction model for low birthweight neonates in public hospitals, North-West Ethiopia: a prospective follow-up study. PG - e120111 LID - 10.1136/bmjopen-2026-120111 [doi] LID - e120111 AB - OBJECTIVES: This study aimed to develop and internally validate a neonatal mortality risk prediction model for low birthweight (LBW) neonates in public hospitals of North-West Ethiopia. DESIGN: An institution-based prospective follow-up study. SETTING: The study was conducted in seven hospitals, comprising three general hospitals and four primary hospitals, between 14 February and 31 October 2025. The general hospitals, Injibara, Finote Selam and Pawi, provide level II neonatal intensive care services, whereas the primary hospitals, Dangila, Chagni, Jawi and Gimja Bet, provide level I newborn care services. These hospitals are situated in the Awi, West Gojjam and Metekel zones of the Amhara and Benishangul Gumuz regions in north-western Ethiopia. PARTICIPANTS: 955 LBW neonates were enrolled in the study. Neonates born outside health facilities were excluded if their birth weight was unknown, particularly those delivered by traditional birth attendants, as were neonates whose first recorded weight was obtained more than 24 hours after birth. Participants were selected using consecutive sampling and data were collected electronically using the KoboCollect mobile application. OUTCOME MEASURES: Data were analysed using R software V.4.4.3. Least Absolute Shrinkage and Selection Operator regression and multivariable logistic regression were used to identify predictors and develop a simplified risk score and nomogram. Model performance was evaluated in terms of discrimination and calibration, while internal validation was performed using bootstrapping. The clinical utility of the model was assessed using decision curve analysis (DCA). RESULTS: The final model included nine predictors: sepsis, perinatal asphyxia, respiratory distress syndrome, absence of exclusive breastfeeding, absence of Kangaroo Mother Care, gestational ages of 28 weeks to <32 weeks and 32 weeks to <37 weeks, and birth weights of <1000 g and 1000-1499 g. The original model demonstrated good discrimination, with an area under the curve of 84.2% (95% CI 81.5% to 86.9%). After internal validation, the simplified risk score and nomogram achieved areas under the curve of 83.85% and 83.5%, respectively. The model showed excellent calibration before and after validation. DCA indicated that the model provides meaningful clinical benefit. CONCLUSIONS: The nomogram and simplified risk score demonstrated excellent calibration and good discriminatory performance. Their application in clinical settings may improve early intervention and potentially reduce neonatal mortality in Ethiopia by enabling rapid, individualised mortality-risk prediction among LBW neonates. However, external validation in different settings is required. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Eshetu, Daniel Mulat AU - Eshetu DM AUID- ORCID: 0009-0007-1201-904X AD - Department of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia danielmulat81@gmail.com. FAU - Kassa, Assefa Andargie AU - Kassa AA AD - Department of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. FAU - Ayele, Wolde Melese AU - Ayele WM AUID- ORCID: 0000-0003-4830-3599 AD - Department of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. FAU - Kassahun, Mulatu AU - Kassahun M AUID- ORCID: 0009-0005-2973-8142 AD - Department of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. FAU - Zeleke, Shashitu Tadele AU - Zeleke ST AD - Department of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. FAU - Anagaw, Betelhem Mekuriaw AU - Anagaw BM AD - Department of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. FAU - Molla, Mikias Getahun AU - Molla MG AD - Department of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. FAU - Sharew, Kalaab Esubalew AU - Sharew KE AUID- ORCID: 0000-0001-5524-7754 AD - Department of Internal Medicine, School of Medicine, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. FAU - Abeje, Birhanu Kassie AU - Abeje BK AD - Biomedical Sciences Education and Service Directorate, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia. FAU - Ayalew, Chalachew Abiyu AU - Ayalew CA AUID- ORCID: 0009-0008-2376-8983 AD - Department of Public Health, College of Medicine and Health Sciences, Injibara University, Injibara, Ethiopia. LA - eng PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20260630 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Ethiopia/epidemiology MH - Infant, Newborn MH - *Infant, Low Birth Weight MH - Hospitals, Public MH - *Infant Mortality MH - Prospective Studies MH - Female MH - Risk Assessment/methods MH - Male MH - Follow-Up Studies MH - Infant MH - Risk Factors MH - Prediction Algorithms MH - Birth Weight MH - Logistic Models MH - ROC Curve PMC - PMC13331094 OTO - NOTNLM OT - EPIDEMIOLOGIC STUDIES OT - Ethiopia OT - Mortality OT - NEONATOLOGY COIS- Competing interests: None declared. EDAT- 2026/07/01 00:35 MHDA- 2026/07/01 18:34 PMCR- 2026/06/30 CRDT- 2026/06/30 21:03 PHST- 2026/07/01 18:34 [medline] PHST- 2026/07/01 00:35 [pubmed] PHST- 2026/06/30 21:03 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - bmjopen-2026-120111 [pii] AID - 10.1136/bmjopen-2026-120111 [doi] PST - epublish SO - BMJ Open. 2026 Jun 30;16(6):e120111. doi: 10.1136/bmjopen-2026-120111. PMID- 42379099 OWN - NLM STAT- MEDLINE DCOM- 20261021 LR - 20261021 IS - 1879-1271 (Electronic) IS - 0268-0033 (Linking) VI - 138 DP - 2026 Aug TI - Exploring real-world lumbar posture behaviour. A whole day comparison of individuals with low back pain and healthy controls. PG - 106908 LID - S0268-0033(26)00163-4 [pii] LID - 10.1016/j.clinbiomech.2026.106908 [doi] AB - BACKGROUND: Previous research of lumbar posture on individuals with low back pain (LBP) has produced conflicting findings compared to control groups. This research has been limited by environmental or task constraints. Real-world postural behaviour across an entire day remains poorly understood. This study examined whole-day lumbar posture characteristics in people with and without LBP using wearable sensors. METHODS: 13 people with LBP and 11 healthy controls volunteered for this study. A three-accelerometer setup was used to measure real-world lumbar posture classifying sitting and standing. Data were normalised to individual maximum ranges. Differences in measures of mean posture, variability, fidgeting, and posture-use frequency distributions, were derived. FINDINGS: An average of 350 min of data per person was available for analysis. Overall, between group differences were small. LBP demonstrated more flexed posture use in standing and a more flexed sitting frequency distribution. INTERPRETATION: Real-world posture behaviour was similar between individuals with and without LBP. Where differences were determined they related to temporal components such as frequencies which are masked with traditional postural estimates. These findings suggest that posture-pain relationships may vary substantially between individuals, emphasising the need for person-specific analysis in future research. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - McClintock, Frederick A AU - McClintock FA AD - Department of Rehabilitation and Sport Sciences, Bournemouth University, Bournemouth, UK. Electronic address: fmcclintock@bournemouth.ac.uk. FAU - Callaway, Andrew J AU - Callaway AJ AD - Department of Rehabilitation and Sport Sciences, Bournemouth University, Bournemouth, UK. FAU - Clark, Carol J AU - Clark CJ AD - Department of Rehabilitation and Sport Sciences, Bournemouth University, Bournemouth, UK. FAU - Munoz-Gomez, Elena AU - Munoz-Gomez E AD - Research Unit in Clinical Biomechanics (UBIC), Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, 46010, Valencia, Spain. FAU - Alqhtani, Raee S AU - Alqhtani RS AD - College of Applied Medical Science, Najran University, Najran, P.O. Box 1988, Saudi Arabia. FAU - Williams, Jonathan M AU - Williams JM AD - Department of Rehabilitation and Sport Sciences, Bournemouth University, Bournemouth, UK. LA - eng PT - Comparative Study PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20260629 PL - England TA - Clin Biomech (Bristol) JT - Clinical biomechanics (Bristol, Avon) JID - 8611877 SB - IM MH - *Posture/physiology MH - *Low Back Pain/physiopathology MH - *Lumbar Vertebrae/physiopathology MH - Case-Control Studies MH - Wearable Electronic Devices MH - Healthy Volunteers MH - Accelerometry/instrumentation MH - Sitting Position MH - Standing Position MH - Cross-Sectional Studies MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged OTO - NOTNLM OT - Discomfort OT - Ecological validity OT - Field-based OT - Lordosis OT - Provocation OT - Spine OT - Variability COIS- Declaration of competing interest The authors declare no conflict of interest. EDAT- 2026/07/01 00:35 MHDA- 2026/07/15 12:37 CRDT- 2026/06/30 18:09 PHST- 2025/11/13 00:00 [received] PHST- 2026/03/27 00:00 [revised] PHST- 2026/06/28 00:00 [accepted] PHST- 2026/07/15 12:37 [medline] PHST- 2026/07/01 00:35 [pubmed] PHST- 2026/06/30 18:09 [entrez] AID - S0268-0033(26)00163-4 [pii] AID - 10.1016/j.clinbiomech.2026.106908 [doi] PST - ppublish SO - Clin Biomech (Bristol). 2026 Aug;138:106908. doi: 10.1016/j.clinbiomech.2026.106908. Epub 2026 Jun 29. PMID- 42379026 OWN - NLM STAT- MEDLINE DCOM- 20260724 LR - 20260724 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 268 DP - 2026 Aug TI - Physical activity and loneliness in rural left-behind children: The mediating roles of social anxiety and self-concept. PG - 107262 LID - S0001-6918(26)01063-2 [pii] LID - 10.1016/j.actpsy.2026.107262 [doi] AB - BACKGROUND: Loneliness is a prominent mental health concern among rural left-behind children in China, yet the psychological pathways through which physical activity may be related to loneliness remain underexplored. OBJECTIVE: This study explores the psychosocial pathways linking physical activity to loneliness in rural left-behind children, with particular focus on the chain-mediating effects of self-concept and social anxiety. METHODS: A sample of 540 Chinese rural left-behind children completed the scales that assessed loneliness, physical activity, social anxiety, and self-concept. SPSS 27.0 was used to conduct the common method bias test, reliability analysis, and correlation analysis. Mplus 8.3 was then employed to explore the mediating roles of social anxiety and self-concept within a chained mediation model. RESULTS: Common method bias was determined to be within acceptable limits for this study. Key findings include: (1) A negative correlation exists between physical activity and loneliness, with physical activity substantially correlated with loneliness (beta = -0.322); (2) Social anxiety partially mediated the relationship between physical activity and loneliness (beta = -0.117), accounting for 22.1% of the total effect; (3) Self-concept also partially mediated the relationship between physical activity and loneliness (beta = -0.132), representing 24.9% of the total effect; (4) A conspicuous chain mediating effect was observed through social anxiety and self-concept (beta = -0.013), accounting for 3.5% of the total effect (all p < 0.001). CONCLUSION: Physical activity is directly and indirectly associated with loneliness among RLBC, with social anxiety and self-concept serving as mediating variables in a chain mediating pathway. These findings are consistent with attachment theory in that higher physical activity is associated with lower loneliness, which may reflect alternative sources of social connection; the observed patterns suggest that school-based physical activity programs designed to address social anxiety and self-concept could be associated with lower loneliness, though this awaits testing in longitudinal or experimental research. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Peng, Dianhui AU - Peng D AD - Department of Sport Education, Hunan Normal University, Changsha, Hunan, China; Department of Art, Beijing Sport University, Beijing, China. FAU - Li, Si AU - Li S AD - Department of Sport Education, Hunan Normal University, Changsha, Hunan, China. FAU - Luo, Yipin AU - Luo Y AD - Department of Sport Education, Hunan Normal University, Changsha, Hunan, China. FAU - Li, Xiaolin AU - Li X AD - Department of Sport Education, Hunan Normal University, Changsha, Hunan, China. FAU - Long, Jiayi AU - Long J AD - Department of Sport Education, Hunan Normal University, Changsha, Hunan, China. FAU - Chen, Jiaxi AU - Chen J AD - Department of Sport Education, Hunan Normal University, Changsha, Hunan, China. FAU - Lu, Chunxia AU - Lu C AD - Department of Sport Education, Hunan Normal University, Changsha, Hunan, China. Electronic address: luchunxia@hunnu.edu.cn. FAU - Wang, Yujuan AU - Wang Y AD - Sports and Health Promotion, Hunan University of Finance and Economics, Changsha, Hunan, China. Electronic address: wangyujuan@hufe.edu.cn. LA - eng PT - Journal Article DEP - 20260630 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM MH - Humans MH - *Loneliness/psychology MH - *Self Concept MH - Female MH - Male MH - Child MH - *Rural Population MH - China MH - *Exercise/psychology MH - *Anxiety/psychology OTO - NOTNLM OT - Left-behind children OT - Loneliness OT - Physical activity OT - Self-concept OT - Social anxiety COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Chunxia Lu reports financial support was provided by the Social Science General Project of Hunan Province. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/07/01 00:35 MHDA- 2026/07/24 06:35 CRDT- 2026/06/30 18:07 PHST- 2025/05/13 00:00 [received] PHST- 2026/06/05 00:00 [revised] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/07/24 06:35 [medline] PHST- 2026/07/01 00:35 [pubmed] PHST- 2026/06/30 18:07 [entrez] AID - S0001-6918(26)01063-2 [pii] AID - 10.1016/j.actpsy.2026.107262 [doi] PST - ppublish SO - Acta Psychol (Amst). 2026 Aug;268:107262. doi: 10.1016/j.actpsy.2026.107262. Epub 2026 Jun 30. PMID- 42378424 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260917 IS - 1540-8167 (Electronic) IS - 1045-3873 (Print) IS - 1045-3873 (Linking) VI - 37 IP - 9 DP - 2026 Sep TI - Long-Term Serial Exercise Stress Testing in Catecholaminergic Polymorphic Ventricular Tachycardia on Beta-Blocker and Flecainide Therapy. PG - 1939-1946 LID - 10.1111/jce.70429 [doi] AB - INTRODUCTION: Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a potentially life-threatening arrhythmic disorder typically treated with beta-blockers and, occasionally, with flecainide. METHODS: All patients underwent genetic testing, electrocardiogram, echocardiogram, and exercise testing. Ventricular arrhythmias were assessed using qualitative and quantitative scoring systems. Flecainide dosing was progressively titrated, and follow-up extended from 2007 to 2024. RESULTS: Among 235 genetically confirmed carriers of the RyR2 (ryanodine receptor 2) p.Gly357Ser mutation, 32 required combination therapy with beta-blockers and flecainide (age at diagnosis 18 [1-55] years; age at flecainide initiation 32 [15-66] years; 50% male). Forty-seven percent had an implantable cardioverter defibrillator (ICD). Flecainide was indicated for exercise-induced ventricular arrhythmias despite beta-blocker therapy, and the median treatment duration was 7.3 years. All patients received propranolol (median dose 65 mg/day). Flecainide (median dose 100 mg/day) was well tolerated, with no syncope or stress-induced symptoms. Before flecainide, five patients (16%) experienced ventricular arrhythmic events recorded by the ICD, including two requiring appropriate shocks; no events occurred after treatment initiation. Both qualitative (2.07 +/- 0.77 vs. 1.22 +/- 1.08, p < 0.001) and quantitative (69.78 +/- 83.17 vs. 15.29 +/- 5.53, p < 0.001) arrhythmic scores improved significantly. Additionally, maximum heart rate and the percentage of age-predicted maximum heart rate were significantly reduced, while metabolic equivalents increased significantly (12.3 +/- 3.8 vs. 14.7 +/- 7.5; p = 0.010). CONCLUSION: In CPVT patients, the addition of flecainide to beta-blocker therapy was associated with a significant reduction in arrhythmic burden and improvement in exercise-related parameters during long-term follow-up. CI - (c) 2026 The Author(s). Journal of Cardiovascular Electrophysiology published by Wiley Periodicals LLC. FAU - Wanguemert-Perez, Fernando AU - Wanguemert-Perez F AD - Cardiavant, Centro Medico Cardiologico, Las Palmas de Gran Canaria, Spain. FAU - Ostos-Canero, German AU - Ostos-Canero G AD - Cardiavant, Centro Medico Cardiologico, Las Palmas de Gran Canaria, Spain. FAU - Wanguemert-Guerra, Marta AU - Wanguemert-Guerra M AD - Cardiavant, Centro Medico Cardiologico, Las Palmas de Gran Canaria, Spain. FAU - Acosta-Materan, Carlos AU - Acosta-Materan C AD - Cardiavant, Centro Medico Cardiologico, Las Palmas de Gran Canaria, Spain. FAU - Cardenes-Leon, Aridane AU - Cardenes-Leon A AD - Cardiology Service, Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Spain. FAU - Caballero-Dorta, Eduardo AU - Caballero-Dorta E AD - Cardiology Service, Hospital Universitario de Gran Canaria Dr. Negrin, Las Palmas de Gran Canaria, Spain. AD - Faculty of Health Sciences, Department of Medical and Surgical Sciences, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. FAU - Perez-Rodriguez, Kevin AU - Perez-Rodriguez K AD - Cardiology Service, Complejo Hospitalario Universitario Insular-Materno Infantil, Las Palmas de Gran Canaria, Spain. FAU - Brugada, Ramon AU - Brugada R AD - Cardiovascular Genetics Center, Institut d'Investigacio Biomedica de Girona Dr. Josep Trueta, Girona, Spain. FAU - Brugada, Josep AU - Brugada J AD - Arrhythmia Section, Cardiology Department, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain. FAU - Martinez-Quintana, Efren AU - Martinez-Quintana E AUID- ORCID: 0000-0002-1289-7279 AD - Cardiavant, Centro Medico Cardiologico, Las Palmas de Gran Canaria, Spain. AD - Faculty of Health Sciences, Department of Medical and Surgical Sciences, Universidad de Las Palmas de Gran Canaria, Las Palmas de Gran Canaria, Spain. AD - Cardiology Service, Complejo Hospitalario Universitario Insular-Materno Infantil, Las Palmas de Gran Canaria, Spain. LA - eng GR - Fundacion Canaria UMIAYA for the care of sudden death/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260630 PL - United States TA - J Cardiovasc Electrophysiol JT - Journal of cardiovascular electrophysiology JID - 9010756 RN - K94FTS1806 (Flecainide) RN - 0 (Adrenergic beta-Antagonists) RN - 0 (Anti-Arrhythmia Agents) RN - 0 (Ryanodine Receptor Calcium Release Channel) RN - 0 (RyR2 protein, human) RN - 9Y8NXQ24VQ (Propranolol) SB - IM MH - Humans MH - *Flecainide/therapeutic use/adverse effects MH - *Tachycardia, Ventricular/drug therapy/physiopathology/diagnosis/genetics MH - Polymorphic Catecholaminergic Ventricular Tachycardia MH - *Exercise Test MH - Middle Aged MH - *Adrenergic beta-Antagonists/therapeutic use/adverse effects MH - Treatment Outcome MH - *Anti-Arrhythmia Agents/therapeutic use/adverse effects MH - Time Factors MH - Female MH - Adult MH - Male MH - Adolescent MH - Young Adult MH - Ryanodine Receptor Calcium Release Channel/genetics MH - Child MH - Aged MH - *Heart Rate/drug effects MH - Child, Preschool MH - Predictive Value of Tests MH - Drug Therapy, Combination MH - Mutation MH - *Propranolol/therapeutic use/adverse effects PMC - PMC13576541 OTO - NOTNLM OT - beta-blockers OT - catecholaminergic polymorphic ventricular tachycardia (CPVT) OT - exercise capacity OT - flecainide OT - treadmill ergometry COIS- The authors declare no conflicts of interest. EDAT- 2026/06/30 18:42 MHDA- 2026/09/15 11:37 PMCR- 2026/09/15 CRDT- 2026/06/30 14:53 PHST- 2026/04/22 00:00 [revised] PHST- 2026/02/23 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/09/15 11:37 [medline] PHST- 2026/06/30 18:42 [pubmed] PHST- 2026/06/30 14:53 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - JCE70429 [pii] AID - 10.1111/jce.70429 [doi] PST - ppublish SO - J Cardiovasc Electrophysiol. 2026 Sep;37(9):1939-1946. doi: 10.1111/jce.70429. Epub 2026 Jun 30. PMID- 42378256 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260926 IS - 2369-2960 (Electronic) IS - 2369-2960 (Linking) VI - 12 DP - 2026 Jun 30 TI - Comparison of Measured 24-Hour Urinary Salt Excretion With Spot Urine and 24-Hour Dietary Recall Estimates Among Adolescents and Parents: Cross-Sectional Study. PG - e85549 LID - 10.2196/85549 [doi] LID - e85549 AB - BACKGROUND: Hypertension, a leading cause of cardiovascular disease, is a significant public health challenge, with urban India reporting prevalence rates up to 40%. Excessive salt intake, averaging 8 to 11 g/day in India, far exceeds the World Health Organization-recommended limit of 5 g/day and is a key modifiable risk factor. While 24-hour urine collection is the gold standard for measuring 24-hour urinary excreted salt levels, its practicality in large-scale studies is limited, necessitating alternative methods such as spot urine sampling and dietary recall. OBJECTIVE: This study aimed to address current knowledge gaps by evaluating 24-hour urinary excretory salt levels across age groups and comparing the gold standard of 24-hour urinary salt excretion with estimates from spot urine samples and 24-hour dietary recalls among adolescents and their parents in Chandigarh, India. METHODS: A cross-sectional survey was conducted among 462 adolescents and 395 parents from public schools in Chandigarh, part of a cluster randomized controlled trial focused on reducing chronic disease risk factors. Twenty-four-hour urinary excreted salt levels were measured via 24-hour urine collection, spot urine samples were analyzed with the Kawasaki, Tanaka, and INTERSALT equations, and 2 nonconsecutive 24-hour dietary recalls using a correction factor of 0.9. Bland-Altman plots were used to assess agreement between methods. RESULTS: The mean 24-hour urinary excreted salt levels measured via 24-hour urine samples were 6.95 g/day (SD 0.24; 95% CI 6.48-7.42) for adolescents and 7.73 g/day (SD 0.3; 95% CI 7.18-8.28) for parents. Spot urine estimates showed variability, with the INTERSALT equation with potassium yielding the closest results to 24-hour measurements for parents (mean 8.12, SD 0.4 g/d; 95% CI 7.36-8.95) and adolescents (mean 7.97, SD 0.4 g/day; 95% CI 7.16-8.77). Dietary recall underestimated 24-hour urinary excreted salt levels for both groups (mean 4.15, SD 0.08 g/day for adolescents and mean 3.62, SD 0.08 g/day for parents). CONCLUSIONS: Spot urine sampling, particularly the INTERSALT with potassium equation, offers a feasible alternative to 24-hour urine collection for estimating population-level 24-hour urinary excreted salt levels among adolescents and adults in resource-limited settings. Dietary recall alone significantly underestimates intake and should be supplemented with objective measures. These findings support the use of tailored estimation methods based on age for improved hypertension management strategies in India. CI - (c) Sandeep Kaur, Akashdeep Singh Chauhan, Rajesh Kumar, Manmeet Kaur. Originally published in JMIR Public Health and Surveillance (https://publichealth.jmir.org). FAU - Kaur, Sandeep AU - Kaur S AUID- ORCID: 0000-0003-3170-6703 AD - Faculty of Medicine, Imperial College London, Hammersmith Campus, London, W120NN, United Kingdom, 44 7570297460. AD - Indian Institute of Public Health-Delhi, Public Health Foundation of India, New Delhi, India. AD - Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India. FAU - Chauhan, Akashdeep Singh AU - Chauhan AS AUID- ORCID: 0000-0001-6791-2221 AD - Indian Institute of Public Health-Delhi, Public Health Foundation of India, New Delhi, India. AD - Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India. FAU - Kumar, Rajesh AU - Kumar R AUID- ORCID: 0000-0001-9750-3437 AD - Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India. AD - Health Equity Action Learnings Foundation, Chandigarh, India. FAU - Kaur, Manmeet AU - Kaur M AUID- ORCID: 0000-0003-2450-3115 AD - Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India. AD - Health Equity Action Learnings Foundation, Chandigarh, India. LA - eng SI - CTRI/CTRI/2019/09/021452 PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260630 PL - Canada TA - JMIR Public Health Surveill JT - JMIR public health and surveillance JID - 101669345 RN - 0 (Sodium Chloride, Dietary) SB - IM MH - Humans MH - Adolescent MH - Cross-Sectional Studies MH - Male MH - India/epidemiology MH - Female MH - *Sodium Chloride, Dietary/urine MH - *Urine Specimen Collection/methods MH - *Parents/psychology MH - Child MH - Adult MH - *Urinalysis/methods MH - *Mental Recall PMC - PMC13317844 OTO - NOTNLM OT - 24-hour urine collection OT - adolescents OT - cardiovascular diseases OT - chronic diseases OT - dietary recall OT - excretory salt OT - hypertension OT - spot urine sampling OT - urinary excreted salt levels COIS- Conflicts of Interest: None declared. EDAT- 2026/06/30 22:37 MHDA- 2026/06/30 22:38 PMCR- 2026/06/30 CRDT- 2026/06/30 13:42 PHST- 2025/10/10 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/06/30 22:38 [medline] PHST- 2026/06/30 22:37 [pubmed] PHST- 2026/06/30 13:42 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - v12i1e85549 [pii] AID - 85549 [pii] AID - 10.2196/85549 [doi] PST - epublish SO - JMIR Public Health Surveill. 2026 Jun 30;12:e85549. doi: 10.2196/85549. PMID- 42378255 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - Study Protocol for "Exploring the safety and therapeutic potential of psilocybin in the treatment of anorexia nervosa in adolescents and young adults". PG - e0352246 LID - 10.1371/journal.pone.0352246 [doi] LID - e0352246 AB - BACKGROUND: Anorexia nervosa (AN) is a severe psychiatric disorder with high morbidity, mortality, and relapse rates, most commonly emerging during adolescence. Despite specialized psychological and nutritional treatments, outcomes remain suboptimal, with high rates of relapse and chronicity. Psilocybin has been investigated with preliminary efficacy in other psychiatric conditions characterized by rigidity and treatment resistance, but clinical evidence in AN-particularly in adolescents-is limited. OBJECTIVE: The psiAN study aims to evaluate the safety, tolerability, and feasibility of psilocybin therapy combined with psychological support in adolescents and young adults with relapsing AN, while exploring clinical, experiential, and neurobiological correlates of change. METHODS: A phase IIa, open-label, randomized controlled trial enrolling individuals aged 16-35 years with DSM-5 AN and a history of relapse. Participants are randomized to receive either two administrations of psilocybin (25 mg) with manualized psychological support plus treatment as usual (TAU), or TAU alone. Primary outcomes focus on safety and tolerability, assessed through adverse events, psychiatric monitoring, and medical parameters measured from first dosing to primary endpoint. Secondary outcomes include change in eating disorder symptom severity, relapse composite measures, mood, well-being, personality traits from baseline to primary endpoint with follow-up to 12 months. Functional magnetic resonance imaging (fMRI) and peripheral brain-derived neurotrophic factor are included as exploratory mechanistic measures. fMRI will evaluate pre- to post-intervention changes in structural and functional connectivity and task-related responses during a simplified Monetary Incentive Delay task (MIDT) and a Calorie-Cue Task (CCT). ClinicalTrials.gov Identifier: NCT07169747. ETHICS AND DISSEMINATION: The study follows Good Clinical Practice (GCP), the Declaration of Helsinki, and EU Clinical Trials Regulation requirements, with staged inclusion of adolescents (16-17-year-olds) after a safety board review of adult data (18-35-year-olds). This protocol was prepared with reference to the SPIRIT 2025 guidelines (Chan et al., 2025) to enhance transparency and inform future trials. CI - Copyright: (c) 2026 Sjostrom et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Sjostrom, David AU - Sjostrom D AUID- ORCID: 0000-0003-0004-1892 AD - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. FAU - Schau Ryback, Olea AU - Schau Ryback O AD - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. AD - Adult Psychiatry, Skane University Hospital, Lund, Sweden. FAU - Claesdotter Knutsson, Emma AU - Claesdotter Knutsson E AD - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. AD - Child and Adolescent Psychiatry, Skane University Hospital, Lund, Sweden. FAU - Kajonius, Petri AU - Kajonius P AD - Department of Psychology, Lund University, Lund, Sweden. FAU - Jensen Sonden, Oskar AU - Jensen Sonden O AD - Department of Psychology, Lund University, Lund, Sweden. FAU - Carlbring, Per AU - Carlbring P AUID- ORCID: 0000-0002-2172-8813 AD - Department of Psychology, Stockholm University, Stockholm, Sweden. AD - School of Psychology, Korea University, Seoul, South Korea. FAU - Bjorkstrand, Johannes AU - Bjorkstrand J AD - Department of Psychology, Lund University, Lund, Sweden. FAU - Movahed Rad, Pouya AU - Movahed Rad P AUID- ORCID: 0000-0003-2041-3550 AD - Department of Clinical Sciences, Faculty of Medicine, Lund University, Lund, Sweden. AD - Adult Psychiatry, Skane University Hospital, Lund, Sweden. LA - eng SI - ClinicalTrials.gov/NCT07169747 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260630 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 2RV7212BP0 (Psilocybin) RN - 0 (Hallucinogens) SB - IM MH - Humans MH - *Anorexia Nervosa/drug therapy/psychology MH - *Psilocybin/therapeutic use/adverse effects/administration & dosage MH - Adolescent MH - Young Adult MH - Randomized Controlled Trials as Topic MH - Adult MH - Female MH - Clinical Trials, Phase II as Topic MH - Treatment Outcome MH - *Hallucinogens/therapeutic use/adverse effects PMC - PMC13318048 COIS- The authors have declared that no competing interests exist. EDAT- 2026/06/30 22:37 MHDA- 2026/06/30 22:38 PMCR- 2026/06/30 CRDT- 2026/06/30 13:34 PHST- 2026/05/18 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/06/30 22:38 [medline] PHST- 2026/06/30 22:37 [pubmed] PHST- 2026/06/30 13:34 [entrez] PHST- 2026/06/30 00:00 [pmc-release] AID - PONE-D-26-20879 [pii] AID - 10.1371/journal.pone.0352246 [doi] PST - epublish SO - PLoS One. 2026 Jun 30;21(6):e0352246. doi: 10.1371/journal.pone.0352246. eCollection 2026. PMID- 42377367 OWN - NLM STAT- MEDLINE DCOM- 20260720 LR - 20260820 IS - 1699-5198 (Electronic) IS - 0212-1611 (Linking) VI - 43 IP - Spec No4 DP - 2026 Jul 20 TI - EnComCol Study on the diet of children and young people at home and in schools: design and methodology. PG - 41-45 LID - 10.20960/nh.06963 [doi] AB - EnComCol is an observational, crosssectional, multicentre study assessing diet in Spanish children and adolescents (6-17 years) by comparing intake at home with that in the school canteen. It is framed by the continuing burden of childhood overweight/obesity and Royal Decree 315/2025, which harmonises criteria for school menus and portions. The main aim is to identify differences in foods, beverages and nutrient intake according to canteen use, school ownership (public, charter, or private) and residence across six mainland regions, considering six daily mealtimes eating occasions. The sample comprises 1,000 urban participants, balanced by age (50 % 6-11; 50 % 12-17) and sex, with quotas for school type (75 % public, 20 % charter, 5 % private) and geographic distribution using Nielsen areas. For ages 6-11, quotas ensure a 50/50 split between canteen users and nonusers. Methods include a structured 24 hours recall dietary record plus sociodemographic, anthropometric and lifestyle variables. Data collection has three phases: recruitment and a technology-assisted interview; a food diary with telephone interview; and researcher telephone validation, with digital coding and nutrient conversion using updated food-composition tables. Analyses will use descriptive and inferential statistics, mean/proportion comparisons, multivariable models and stratification by age, sex, school type, canteen use and region (p < 0.05). Findings will enable direct comparison with prior research and quantification of critical nutrients (saturated fat, sugars and salt) across contexts. FAU - Urrialde, Rafael AU - Urrialde R AD - Department of Genetics, Physiology and Microbiology. Faculty of Biological Sciences. Universidad Complutense de Madrid. Grupo de Investigacion en Nutricion, Ejercicio y Estilo de Vida Saludable-ImFINE. Department of Health and Human Performance. Universid. FAU - Modrego, Javier AU - Modrego J AD - Grupo de Investigacion en Nutricion, Ejercicio y Estilo de Vida Saludable-ImFINE. Department of Health and Human Performance. Universidad Politecnica de Madrid. Sociedad Espanola de Nutricion (SEN). Faculty of Physical Activity and Sports Sciences (INEF). FAU - Gesteiro, Eva AU - Gesteiro E AD - Grupo de Investigacion en Nutricion, Ejercicio y Estilo de Vida Saludable-ImFINE. Department of Health and Human Performance. Universidad Politecnica de Madrid. Sociedad Espanola de Nutricion (SEN). Faculty of Physical Activity and Sports Sciences (INEF). FAU - Zapico, Augusto G AU - Zapico AG AD - Grupo de Investigacion en Nutricion, Ejercicio y Estilo de Vida Saludable-ImFINE. Department of Health and Human Performance. Universidad Politecnica de Madrid. Sociedad Espanola de Nutricion (SEN). Faculty of Physical Activity and Sports Sciences (INEF). FAU - Lopez Flores, Jessica AU - Lopez Flores J AD - Grupo de Investigacion en Nutricion, Ejercicio y Estilo de Vida Saludable-ImFINE. Department of Health and Human Performance. Universidad Politecnica de Madrid. Sociedad Espanola de Nutricion (SEN). Faculty of Physical Activity and Sports Sciences (INEF). FAU - Gonzalez-Gross, Marcela AU - Gonzalez-Gross M AD - ImFINE Research Group, Health and Human Performance Department, Faculty of Physical Activity and Sport Sciences, Universidad Politecnica de Madrid, 28040 Madrid. LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study TT - Estudio EnComCol sobre alimentacion en poblacion infantil y juvenil en el hogar y colegios: diseno y metodologia. PL - Spain TA - Nutr Hosp JT - Nutricion hospitalaria JID - 9100365 SB - IM MH - Humans MH - Child MH - Female MH - *Schools MH - Male MH - Adolescent MH - *Diet MH - Cross-Sectional Studies MH - Spain/epidemiology MH - Research Design MH - Diet Records OTO - NOTNLM OT - Comedor escolar. Registro dietetico de 24 horas. Registro estilo de vida. Nutrientes criticos. Ninos. Adolescentes. EDAT- 2026/06/30 16:10 MHDA- 2026/07/20 06:38 CRDT- 2026/06/30 10:53 PHST- 2026/07/20 06:38 [medline] PHST- 2026/06/30 16:10 [pubmed] PHST- 2026/06/30 10:53 [entrez] AID - 10.20960/nh.06963 [doi] PST - ppublish SO - Nutr Hosp. 2026 Jul 20;43(Spec No4):41-45. doi: 10.20960/nh.06963. PMID- 42376979 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 2544-4646 (Electronic) IS - 1733-1331 (Print) IS - 1733-1331 (Linking) VI - 75 IP - 2 DP - 2026 Jun 1 TI - Longitudinal Changes in Selected Gut Microorganisms During Gluten-Free Diet in Pediatric Coeliac Disease. PG - 195-209 LID - 10.33073/pjm-2026-017 [doi] AB - Alterations in gut microbiota have been reported in coeliac disease (CeD). However, longitudinal evidence distinguishing disease-related effects from diet-driven changes after gluten-free diet initiation remains scarce, particularly in pediatric cohorts. The present study aimed to evaluate time-dependent changes in selected intestinal microorganisms in children with CeD before and during adherence to a gluten-free diet and to compare these findings with those of healthy controls. Microbial DNA isolates from stool samples of pediatric patients with CeD (n = 24) and healthy children (n = 24) were analyzed by quantitative real-time PCR. Samples from CeD patients were categorized into four time points: pre-diet, 6-month, 1-year, and 2-year follow-up. The healthy controls were assessed once. The prevalence and microbial load of selected microorganisms were evaluated. Bifidobacterium spp. remained highly prevalent across all time points, although their abundance varied significantly over follow-up, with the lowest levels at one year and higher levels at two years, comparable to those in controls. The prevalence of Candida tropicalis increased significantly during dietary treatment, reaching levels similar to those of healthy children after two years. Saccharomyces cerevisiae showed a gradual rise in prevalence and abundance, whereas Methanobrevibacter smithii remained infrequent with low and fluctuating microbial load. The duration of adherence to a gluten-free diet appears to influence gut microbial profiles in pediatric CeD. The selected gut microbiota microorganisms' assessment may serve as a complementary tool for understanding intestinal adaptation during dietary treatment, however, its routine clinical application requires further validation. CI - (c) 2026 Aleksandra Zieba et al. FAU - Zieba, Aleksandra AU - Zieba A AD - 1Student of Dietetics, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland. FAU - Drozdz, Kamil AU - Drozdz K AD - 2Department of Molecular Medical Microbiology, Chair of Microbiology, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland. FAU - Krawczyk, Agnieszka AU - Krawczyk A AD - 2Department of Molecular Medical Microbiology, Chair of Microbiology, Faculty of Medicine, Jagiellonian University Medical College, Cracow, Poland. LA - eng PT - Journal Article DEP - 20260629 PL - Poland TA - Pol J Microbiol JT - Polish journal of microbiology JID - 101229003 SB - IM MH - Humans MH - *Celiac Disease/microbiology/diet therapy MH - *Diet, Gluten-Free MH - Child MH - *Gastrointestinal Microbiome MH - Male MH - Female MH - Feces/microbiology MH - Child, Preschool MH - *Bacteria/classification/genetics/isolation & purification MH - Longitudinal Studies MH - Adolescent PMC - PMC13446153 OTO - NOTNLM OT - coeliac disease OT - gluten-free diet OT - gut microbiota OT - pediatric patients OT - qPCR COIS- Conflict of interest The authors do not report any financial or personal connections with other persons or organizations, which might negatively affect the contents of this publication and/or claim authorship rights to this publication. EDAT- 2026/06/30 16:10 MHDA- 2026/08/06 12:37 PMCR- 2026/06/29 CRDT- 2026/06/30 08:14 PHST- 2026/02/12 00:00 [received] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/08/06 12:37 [medline] PHST- 2026/06/30 16:10 [pubmed] PHST- 2026/06/30 08:14 [entrez] PHST- 2026/06/29 00:00 [pmc-release] AID - pjm-2026-017 [pii] AID - 10.33073/pjm-2026-017 [doi] PST - epublish SO - Pol J Microbiol. 2026 Jun 29;75(2):195-209. doi: 10.33073/pjm-2026-017. eCollection 2026 Jun 1. PMID- 42376252 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260630 LR - 20260813 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Sense of Coherence in patients with stable schizophrenia: multidimensional determinants from a cross-sectional study of 438 inpatients in Guangzhou, China. PG - 1750488 LID - 10.3389/fpsyt.2026.1750488 [doi] LID - 1750488 AB - INTRODUCTION: Schizophrenia, a chronic psychiatric disorder, profoundly affects social functioning and quality of life. The Sense of Coherence (SOC), a core construct in salutogenic theory, plays a pivotal role in stress coping and recovery outcomes. While SOC has been studied in general populations, its determinants in stabilized schizophrenia inpatients remain underexplored. This study comprehensively investigated the Sense of Coherence (SOC) profile among stabilized schizophrenia inpatients by assessing its current status, exploring the interrelationships between SOC and demographic factors/Big Five personality traits (CBF-PI)/social support (SSRS), and identifying factors associated with SOC to inform potential personalized resilience-enhancing interventions. Findings may guide clinical strategies to enhance resilience and mental health recovery and potentially facilitate functional recovery in this population. PATIENTS AND METHODS: A cross-sectional study was conducted at a Guangzhou tertiary psychiatric hospital with 438 stabilized schizophrenia inpatients from November 2024 to February 2025. Data collection included demographic/clinical variables, Chinese Big Five Personality Inventory (CBF-PI), 13-item Sense of Coherence Scale (SOC-13), and the Social Support Rating Scale (SSRS). Statistical analyses were performed using SPSS version 27.0. Descriptive statistics were used to summarize the data and independent-samples t-tests and one-way analysis of variance (ANOVA) were employed to compare SOC scores across demographic and clinical groups. Pearson correlation analysis was conducted to examine the relationships between personality traits, social support, and sense of coherence and multiple linear regression analysis was utilized to identify independent factors influencing sense of coherence (P < 0.05). RESULT: The mean SOC score among the 438 stabilized schizophrenia inpatients was 53.35 +/- 11.81. SOC correlated positively with all five dimensions of CBF-PI-B (P < 0.05), as well as subjective social support (P < 0.01), while showing inverse correlations with objective support (p < 0.01) and support utilization subscales (P < 0.01), Multiple regression identified personal income(yes), frequency of physical activity (>/=3 times/week), and primary caregiver (Children) as significant SOC predictors. CONCLUSION: This study demonstrates that stabilized schizophrenia inpatients in a tertiary psychiatric setting exhibit generally lower Sense of Coherence (SOC) levels compared with healthy normative values and moderately lower than several outpatient schizophrenia samples. Higher SOC was significantly associated with having a personal income, frequent physical activity (>/=3 times/week), having children as primary caregivers, and Chinese Big Five Personality traits. Notably, while subjective support was positively correlated with SOC, objective support and support utilization showed negative associations. Given the moderate internal consistency of the SSRS (Cronbach's alpha = 0.626), the differential associations with social support dimensions should be interpreted cautiously. Concurrently, personality traits are relatively stable, their associations with SOC may inform indirect supportive strategies leveraging existing strengths rather than direct modification. These findings underscore the potential value of tailored interventions that enhance subjective support, promote structured recreational activities, and foster patients' perceived coping resources. Further cross-sectional and longitudinal outpatient studies are warranted to validate these results and elucidate the mechanisms underlying the support paradox. CI - Copyright (c) 2026 Liang, Niu, Huang, Chen, Wu, Chen, Liu, Shi and Zeng. FAU - Liang, Rongyu AU - Liang R AD - Department of Geriatric Psychiatry, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. AD - Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. FAU - Niu, Zangrui AU - Niu Z AD - School of Nursing, Guangzhou Medical University, Guangzhou, China. FAU - Huang, Yuanyuan AU - Huang Y AD - Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. AD - Department of Psychiatry, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. AD - Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China. FAU - Chen, Xiezhen AU - Chen X AD - School of Nursing, Guangzhou Medical University, Guangzhou, China. FAU - Wu, Fengchun AU - Wu F AD - Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. AD - Department of Psychiatry, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. AD - Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China. FAU - Chen, Xiaodong AU - Chen X AD - Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. AD - Chronic Psychiatry Department, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Liu, Cuixia AU - Liu C AD - Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. AD - Chronic Psychiatry Department, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Shi, Xiaolei AU - Shi X AD - Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, China. AD - Cerebrovascular Disease Department, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, China. FAU - Zeng, Gang AU - Zeng G AD - Nursing Department, Guangzhou Chest Hospital Affiliated to Guangdong Pharmaceutical University, Guangzhou, China. AD - State Key Laboratory of Respiratory Disease, Guangzhou, China. AD - Institute of Tuberculosis, Guangzhou Medical University, Guangzhou, China. LA - eng PT - Journal Article DEP - 20260615 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13311124 OTO - NOTNLM OT - Big Five Personality OT - Sense of Coherence OT - inpatients OT - schizophrenia OT - social support COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/30 06:31 MHDA- 2026/06/30 06:32 PMCR- 2026/06/15 CRDT- 2026/06/30 05:25 PHST- 2025/12/18 00:00 [received] PHST- 2026/03/12 00:00 [revised] PHST- 2026/03/12 00:00 [accepted] PHST- 2026/06/30 06:32 [medline] PHST- 2026/06/30 06:31 [pubmed] PHST- 2026/06/30 05:25 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1750488 [doi] PST - epublish SO - Front Psychiatry. 2026 Jun 15;17:1750488. doi: 10.3389/fpsyt.2026.1750488. eCollection 2026. PMID- 42376024 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260630 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Characteristics, predictors, and management of post-extubation dysphagia in critically Ill children: a scoping review. PG - 1854127 LID - 10.3389/fped.2026.1854127 [doi] LID - 1854127 AB - BACKGROUND: Post-extubation dysphagia (PED) is a common complication in critically ill children, associated with aspiration, malnutrition, and prolonged hospitalization. Standardized pediatric-specific assessment and management pathways are lacking, and published studies show substantial heterogeneity in diagnostic criteria, assessment timing, and intervention strategies. OBJECTIVE: This scoping review maps available evidence on pediatric PED, addressing: (1) incidence and clinical characteristics; (2) categories and effect sizes of independent predictors; and (3) the current state of prediction tools, bedside screening instruments, and management strategies. METHODS: Nine databases were searched systematically-PubMed, Embase, Cochrane Library, Web of Science, CINAHL, CNKI, Wanfang, VIP, and CBM-with a search cutoff of 12 March 2026. Fifteen studies were included, encompassing cohort studies, randomized controlled trials, quasi-experimental studies, and scale-development studies. Data were synthesized narratively following the JBI scoping review methodological framework. RESULTS: Included studies were published between 2018 and 2026; 73.3% (11/15) appeared after 2022, originating primarily from mainland China (n = 10) and Brazil (n = 3). The clinical apparent incidence ranged from 28.36% to 68.94%. No included bedside assessment instrument was validated against VFSS or FEES,representing a central methodological gap in the current evidence base.Independent predictors were categorized into three evidence tiers: Tier 1: intubation duration, age, and IWS; Tier 2: neurological comorbidities and number of intubations >/=2; Tier 3:delirium.The CRISPED score is the only prediction tool with temporal internal validation (C-statistic 0.85-0.86). No assessment instrument has been validated against an instrumental gold standard. Interventions centered on oral motor training, with no standardization in frequency, intensity, or multidisciplinary integration. CONCLUSION: Pediatric PED incidence is high and core risk factors have been repeatedly reported across multiple multivariable models, but the field shows substantial heterogeneity in diagnostic definitions, assessment tools, and intervention protocols. The absence of instrumental validation for bedside assessment tools is the central limitation. Key gaps include the absence of gold-standard diagnostic accuracy studies, externally validated prediction models, and standardized intervention pathways. Future research should prioritize multicenter prospective studies to unify diagnostic criteria, develop age-appropriate bedside screening tools, and establish a nurse-led multidisciplinary management framework. SYSTEMATIC REVIEW REGISTRATION: Open Science Framework (OSF), identifier doi: 10.17605/OSF.IO/XSJ9B. CI - (c) 2026 Xue, Zhang, Zhao, Hu, Ju, Sun, Zhang, Zhang, Yang and Guan. FAU - Xue, Yaokang AU - Xue Y AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. AD - School of Nursing, Jilin University, Changchun, China. FAU - Zhang, Baorong AU - Zhang B AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. FAU - Zhao, Xiaoshuang AU - Zhao X AD - Department of Nursing, The First Hospital of Jilin University, Changchun, China. FAU - Hu, Lili AU - Hu L AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. FAU - Ju, Liting AU - Ju L AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. AD - School of Nursing, Jilin University, Changchun, China. FAU - Sun, Hairui AU - Sun H AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. FAU - Zhang, Dan AU - Zhang D AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. FAU - Zhang, Jiping AU - Zhang J AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. FAU - Yang, Yuxuan AU - Yang Y AD - School of Nursing, Jilin University, Changchun, China. FAU - Guan, Ruixin AU - Guan R AD - Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Changchun, China. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260615 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13311104 OTO - NOTNLM OT - management strategies OT - pediatric intensive care OT - pediatrics OT - post-extubation dysphagia OT - predictors OT - scoping review COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/30 06:31 MHDA- 2026/06/30 06:32 PMCR- 2026/06/15 CRDT- 2026/06/30 05:22 PHST- 2026/04/13 00:00 [received] PHST- 2026/05/18 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/30 06:32 [medline] PHST- 2026/06/30 06:31 [pubmed] PHST- 2026/06/30 05:22 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.3389/fped.2026.1854127 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 15;14:1854127. doi: 10.3389/fped.2026.1854127. eCollection 2026. PMID- 42375697 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260630 LR - 20260813 IS - 2673-4842 (Electronic) IS - 2673-4842 (Linking) VI - 7 DP - 2026 TI - Identifying dietary patterns and their association with oral health behaviors in young children: a parent-based cross-sectional study in Lithuania. PG - 1844389 LID - 10.3389/froh.2026.1844389 [doi] LID - 1844389 AB - BACKGROUND: Children's oral health and nutrition are interconnected, jointly influencing growth, oral development, and disease prevention such as caries. Despite this connection, they are often addressed separately in research and practice, underscoring the need for validated parental assessment tools that support integrated and interdisciplinary prevention strategies. METHODS: This cross-sectional study examined underlying dietary patterns among 420 children aged 5-12 years in Kaunas, Lithuania, based on parental reports. Data were collected as part of a broader investigation of oral health behavior (OHB) and knowledge. Children's consumption habits were assessed using 17 structured dietary items, which were further used to adapt nutritional assessment subscales. Ethical approval was obtained from Kaunas Kolegija HEI. Exploratory factor analysis (EFA) was conducted to identify underlying dietary dimensions, and associations with sociodemographic variables and OHB were examined using correlation and regression analyses. RESULTS: EFA revealed a three-factor model explaining 40.30% of total variance, comprising: "recommended healthy foods" (e.g., fruits, vegetables), "inappropriate drinks and snacks" (e.g., sugary beverages), and "dairy products." Dietary measures were not associated with parents' age, gender, or self-perceived nutrition knowledge. Parents' education type was positively associated with "dietary" and "recommended healthy foods", while children's age showed negative associations with these variables, indicating less healthy dietary patterns in older children. OHB was positively associated with "recommended healthy foods", "dietary", and fruit and vegetable intake, but negatively associated with inappropriate drinks and snacks. Regression analysis revealed that consumption of "recommended healthy foods" and "parental success in ensuring healthy eating" as significant independent predictors of optimal OHB. CONCLUSIONS: These findings provide empirical support a multidimensional, parent-based dietary assessment framework that captures distinct eating patterns relevant to oral health. Integrating such tools into oral health promotion may enhance early prevention strategies by linking dietary behaviors with oral hygiene practices in a structured and evidence-based manner. CI - (c) 2026 Buunk-Werkhoven, Tamuliene, Dailidaite and Maciuliene. FAU - Buunk-Werkhoven, Yvonne A B AU - Buunk-Werkhoven YAB AD - Faculty of Medicine, Oral Health Department, Kauno Kolegija Higher Education Institution, Kaunas, Lithuania. FAU - Tamuliene, Rasa AU - Tamuliene R AD - Faculty of Medicine, Oral Health Department, Kauno Kolegija Higher Education Institution, Kaunas, Lithuania. FAU - Dailidaite, Evelina AU - Dailidaite E AD - Faculty of Medicine, Department of Medical Technologies and Dietetics, Kauno Kolegija Higher Education Institution, Kaunas, Lithuania. FAU - Maciuliene, Daiva AU - Maciuliene D AD - Faculty of Medicine, Oral Health Department, Kauno Kolegija Higher Education Institution, Kaunas, Lithuania. LA - eng PT - Journal Article DEP - 20260615 PL - Switzerland TA - Front Oral Health JT - Frontiers in oral health JID - 9918227262706676 PMC - PMC13311115 OTO - NOTNLM OT - Lithuania OT - health promotion OT - oral health and consumption habits OT - parental influence OT - pre- and primary school children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/30 06:31 MHDA- 2026/06/30 06:32 PMCR- 2026/06/15 CRDT- 2026/06/30 05:19 PHST- 2026/03/31 00:00 [received] PHST- 2026/05/06 00:00 [revised] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/06/30 06:32 [medline] PHST- 2026/06/30 06:31 [pubmed] PHST- 2026/06/30 05:19 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.3389/froh.2026.1844389 [doi] PST - epublish SO - Front Oral Health. 2026 Jun 15;7:1844389. doi: 10.3389/froh.2026.1844389. eCollection 2026. PMID- 42375325 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Development and validation of a clinical prediction model for poor ovarian response in assisted reproductive technology. PG - 1732869 LID - 10.3389/fendo.2026.1732869 [doi] LID - 1732869 AB - OBJECTIVE: The aim of this study was to develop and validate a predictive model for poor ovarian response (POR) in patients undergoing Assisted Reproductive Technology (ART). METHODS: This retrospective cohort study included 1,789 patients who underwent IVF/ICSI with a GnRH antagonist protocol at the reproductive medicine center of Shenyang Women's and Children's Hospital between January 2020 and December 2023. Data from January 2020 to April 2023 were used for model development, and data from May 2023 to December 2023 was used for validation. Clinical and ovarian reserve markers were collected. Four prediction models were developed and compared: (1) logistic regression with stepwise selection, (2) full-variable logistic regression, (3) LASSO regression with the minimum lambda (lambda_min) criterion, and (4) LASSO regression with the 1-standard error (1-SE) rule. The optimal model was selected based on discrimination (area under the receiver operating characteristic curve, AUC), calibration, and Brier score. RESULTS: The final model, based on stepwise logistic regression, identified AMH, basal FSH, BMI, and antral follicle count as significant predictors of POR. The model exhibited high discriminatory ability and good calibration across the training, internal validation, and test datasets. The nomogram developed from this model provides an easy-to-use tool for individualized risk prediction, enabling clinicians to optimize treatment strategies for patients at risk of POR. CONCLUSION: This study provides a comprehensive predictive model for POR in ART, incorporating a wide range of clinical and ovarian reserve markers. The stepwise logistic regression model offers superior predictive accuracy and clinical utility, making it a valuable tool for personalized ART management. The nomogram developed enhances decision-making in ART by offering an intuitive, evidence-based method for predicting POR risk. CI - Copyright (c) 2026 Xin, Cheng, Hu, Guo, Li, Zhao and Guo. FAU - Xin, Xin AU - Xin X AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. FAU - Cheng, Zhaoxia AU - Cheng Z AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. FAU - Hu, Ting AU - Hu T AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. FAU - Guo, Yi AU - Guo Y AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. FAU - Li, Nan AU - Li N AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. FAU - Zhao, Junbo AU - Zhao J AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. FAU - Guo, Shuaishuai AU - Guo S AD - Department of Reproductive Medicine, Shenyang Women's and Children's Hospital, Shenyang, Liaoning, China. AD - Liaoning Key Laboratory of Assisted Reproduction, Shenyang, Liaoning, China. AD - Shenyang Clinical Medical Research Center for Assisted Reproduction, Shenyang, Liaoning, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260615 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 80497-65-0 (Anti-Mullerian Hormone) SB - IM MH - Humans MH - Female MH - Retrospective Studies MH - *Reproductive Techniques, Assisted MH - *Ovarian Reserve/physiology MH - Adult MH - *Ovulation Induction/methods MH - Prediction Algorithms MH - Anti-Mullerian Hormone/blood MH - Logistic Models MH - Nomograms MH - Fertilization in Vitro PMC - PMC13310710 OTO - NOTNLM OT - assisted reproductive technology OT - clinical prediction model OT - nomogram OT - ovarian reserve markers OT - poor ovarian response COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/30 06:31 MHDA- 2026/06/30 06:32 PMCR- 2026/06/15 CRDT- 2026/06/30 05:15 PHST- 2025/10/26 00:00 [received] PHST- 2026/03/18 00:00 [revised] PHST- 2026/03/25 00:00 [accepted] PHST- 2026/06/30 06:32 [medline] PHST- 2026/06/30 06:31 [pubmed] PHST- 2026/06/30 05:15 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.3389/fendo.2026.1732869 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Jun 15;17:1732869. doi: 10.3389/fendo.2026.1732869. eCollection 2026. PMID- 42374927 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260905 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 83 IP - 3 DP - 2026 Sep TI - Safety of infant milks: Contamination with cereulide. A commentary by ESPGHAN (European Society for Paediatric Gastroenterology, Hepatology, and Nutrition). PG - 371-373 LID - 10.1002/jpn3.70488 [doi] AB - Since late 2025, precautionary recalls of specific infant and follow-on formula batches in Europe have occurred due to contamination with cereulide, a heat- and acid-stable emetic toxin produced by certain Bacillus cereus strains. Contamination was traced to arachidonic acid (ARA)-containing algal oil from a single supplier; no viable bacteria were detected in the affected products. The European Food Safety Authority established a conservative acute reference dose for infants, and available monitoring data indicate that detected concentrations were generally low and unlikely to pose significant health risks, although some batches may have exceeded precautionary thresholds. This commentary reviews the toxicological background, current risk assessment, analytical challenges, and clinical implications. While cereulide should not be present beyond unavoidable trace levels in infant formula, risk management must remain proportionate and avoid promoting nutritionally inadequate substitutes. Ensuring validated analytical surveillance, stringent raw material control, transparent communication, and continued provision of appropriately regulated formulas containing recommended long-chain polyunsaturated fatty acids, including docosahexaenoic acid (DHA) and ARA, is essential to safeguard infant health and maintain public confidence. CI - (c) 2026 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Haiden, Nadja AU - Haiden N AUID- ORCID: 0000-0003-4806-0312 AD - Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria. FAU - Fewtrell, Mary AU - Fewtrell M AUID- ORCID: 0000-0001-9783-3444 AD - UCL Great Ormond Street Institute of Child Health, London, UK. FAU - Segerstad, Elin Hard Af AU - Segerstad EHA AUID- ORCID: 0000-0002-7676-1186 AD - Pediatric Research Instittute, Oslo University Hospital, Oslo, Norway. AD - Department of Pediatrics, Skane University Hospital, Malmoe, Sweden. FAU - Hojsak, Iva AU - Hojsak I AUID- ORCID: 0000-0003-3262-5964 AD - Children's Hospital Zagreb, University of Zagreb Medical School, Zagreb, Croatia. FAU - Norsa, Lorenzo AU - Norsa L AUID- ORCID: 0000-0003-3322-2921 AD - Pediatric Department, Vittore Buzzi Children's Hospital, Milan. AD - Department of Biomedical and Clinical Science, University of Milan, Milan, Italy. FAU - Koletzko, Berthold AU - Koletzko B AUID- ORCID: 0000-0002-5345-7165 AD - Department of Pediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, Ludwig Maximilians Universitat Munich, Munich, Germany. AD - German Center for Child and Adolescent Health, site, Munich, Germany. LA - eng GR - None/ PT - Journal Article DEP - 20260630 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 RN - 0 (cereulide) RN - 0 (Depsipeptides) SB - IM MH - Humans MH - *Food Contamination/analysis MH - *Infant Formula/chemistry/standards MH - *Depsipeptides/analysis/toxicity MH - Infant MH - *Food Safety MH - Risk Assessment MH - Europe MH - Bacillus cereus MH - Food Microbiology PMC - PMC13539648 OTO - NOTNLM OT - Bacillus cereus OT - infant formula OT - toxine COIS- Outside of submitted work: Nadja Haiden received honoraria, speakers fee, congress fee and/or participated in advisory boards of Baxter, Nutricia/Danone, Nestle, Hipp, Mead Johnson and Chiesi. Mary Fewtrel: None. Elin Hard af Segerstad received speakers fee from Fresenius Kabi, Dr Schar Sweden, and Semper Nutrition. Iva Hojsak received honoraria and speakers fee from Sandoz, Takeda, BioGaia, Hipp, Nutricia, Biocodex, Abbvie, Nestle and GM Pharma. Lorenzo Norsa: Received honoraria, speaker and congress fees and participated to advisory board for Nestle, Danone, Fresenius, Pfizer, Takeda, Sanofi, Vivsol, Zealand. Berthold Koletzko: LMU university hospital and its employee Berthold Koletzko benefitted from financial support for research and educational activities from Budenheim, Danone, DGC, Hipp, Nestle, Pfizer and reckitt. Berthold Koletzko is the Else Kroner Senior Professor of Paediatrics at LMU - University of Munich, financially supported by the charitable Else Kroner Fresenius Foundation, LMU Medical Faculty and LMU University Hospitals. EDAT- 2026/06/30 06:31 MHDA- 2026/09/03 17:36 PMCR- 2026/09/03 CRDT- 2026/06/30 04:03 PHST- 2026/03/18 00:00 [revised] PHST- 2026/03/18 00:00 [received] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/09/03 17:36 [medline] PHST- 2026/06/30 06:31 [pubmed] PHST- 2026/06/30 04:03 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - JPN370488 [pii] AID - 10.1002/jpn3.70488 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Sep;83(3):371-373. doi: 10.1002/jpn3.70488. Epub 2026 Jun 30. PMID- 42374581 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260915 LR - 20260917 IS - 0778-7367 (Print) IS - 2049-3258 (Electronic) IS - 0778-7367 (Linking) VI - 84 IP - 1 DP - 2026 Jun 29 TI - International study of 24-hour movement behaviours among preschool children (SUNRISE): A pilot study from Nepal. LID - 10.1186/s13690-026-01984-2 [doi] LID - 204 AB - BACKGROUND: This study aimed to determine the proportion of Nepali preschool children (3-4 years of age) meeting the World Health Organization (WHO) 24- hour movement guidelines for physical activity (PA), sedentary behaviour and sleep by sex (male vs. female) and place of residence (urban vs. rural) and evaluate their executive functions and motor skills. Furthermore, it evaluated the feasibility and acceptability of methods proposed for the main SUNRISE study in diverse settings. METHODS: In this pilot study, a total of 99 preschool children, balancing sex and place of residence, each with one parent/caregiver, from Syangja District were recruited. Physical activity, sedentary behaviour and sleep were assessed using waist-worn ActiGraph accelerometers (ActiGraph wGT3x-BT) with >/= 1 valid 24-hour period of data, motor skills (gross and fine) were evaluated using the NIH Toolbox motor battery, and executive functions were assessed using the Early Years Toolbox. Eight focus group discussions (FGDs) were carried out with parents/caregivers, and a short interview was conducted with eight Early Childhood Development (ECD) centre teachers to explore the feasibility and acceptability of implementing the SUNRISE protocol. RESULTS: Only 10% of children met all components of the WHO 24-hour movement guidelines (>/= 180 min total PA, of which >/= 60 min were MVPA, /= 1 valid 24-hour period of data. Males and rural children accumulated more daily moderate-to-vigorous and vigorous physical activity than females and urban children, respectively. In contrast, females were more likely to meet screen time guidelines than males (66% vs. 42%, p = 0.018). Additionally, females had better inhibition control than males, and rural children had better working memory than urban children. Parent/caregivers and ECD teachers reported that the study procedures, including accelerometer use, were acceptable and feasible. CONCLUSIONS: Adherence to the full set of WHO movement guidelines was very low among preschool children in this study, with screen time emerging as the most challenging component. Targeted strategies are needed to promote healthier movement behaviours, particularly to reduce screen time. The findings support the feasibility and acceptability of conducting the main SUNRISE study in Nepal. CI - (c) 2026. The Author(s). FAU - Subedi, Narayan AU - Subedi N AD - Nepal Development Society, Kathmandu, Nepal. n.subedi@nedsnepal.org.np. AD - Nexus Institute of Research and Innovation, Kathmandu, Nepal. n.subedi@nedsnepal.org.np. FAU - Okely, Anthony D AU - Okely AD AD - School of Social Sciences, University of Wollongong, Wollongong, NSW, Australia. FAU - Bhandari, Buna AU - Bhandari B AD - Dwyer School of Health Sciences, Division of Health Sciences, Indiana University South Bend, South Bend, USA. FAU - Paudel, Susan AU - Paudel S AD - Nepal Development Society, Kathmandu, Nepal. AD - Centre for Adolescent Health, Department of Paediatrics, Melbourne Medical School, The University of Melbourne, Melbourne, Australia. LA - eng PT - Journal Article DEP - 20260629 PL - England TA - Arch Public Health JT - Archives of public health = Archives belges de sante publique JID - 9208826 PMC - PMC13576209 OTO - NOTNLM OT - 24-hour movement behaviour OT - Nepal OT - Physical activity OT - Preschool children OT - SUNRISE OT - Screen time OT - Urban and rural COIS- Declarations. Ethics approval and consent to participate: The SUNRISE pilot study received ethics approval from the Nepal Health Research Council (Registration number 225/2023). Written approval was obtained from the respective municipalities. All study participants (parents/caregivers) signed the informed consent form. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/30 06:31 MHDA- 2026/06/30 06:32 PMCR- 2026/06/29 CRDT- 2026/06/30 00:07 PHST- 2025/11/28 00:00 [received] PHST- 2026/06/06 00:00 [accepted] PHST- 2026/06/30 06:32 [medline] PHST- 2026/06/30 06:31 [pubmed] PHST- 2026/06/30 00:07 [entrez] PHST- 2026/06/29 00:00 [pmc-release] AID - 10.1186/s13690-026-01984-2 [pii] AID - 1984 [pii] AID - 10.1186/s13690-026-01984-2 [doi] PST - epublish SO - Arch Public Health. 2026 Jun 29;84(1):204. doi: 10.1186/s13690-026-01984-2. PMID- 42372278 OWN - NLM STAT- MEDLINE DCOM- 20260914 LR - 20260914 IS - 1539-3704 (Electronic) IS - 0003-4819 (Linking) VI - 179 IP - 9 DP - 2026 Sep TI - Leveraging Real-World Evidence to Inform Regulatory, Clinical, and Coverage Decisions Related to Glucagon-like Peptide-1-Based Therapies: Synopsis of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop. PG - 1328-1337 LID - 10.7326/ANNALS-25-05468 [doi] AB - Glucagon-like peptide-1 receptor agonists (GLP-1RAs) have transformed obesity and diabetes management, with rapidly expanding indications and use among U.S. adults. Despite their promise, key questions remain about optimal treatment pathways, long-term safety, effectiveness across diverse populations, adherence, and economic impact. Real-world evidence (RWE) derived from electronic health records, claims, and other data sources could address these gaps, but unique challenges complicate its use, such as inconsistent insurance coverage, high discontinuation rates, medication shortages, compounded formulations, and off-label prescribing. To explore these issues, the National Institute of Diabetes and Digestive and Kidney Diseases convened a workshop in May 2025 with experts from regulatory agencies, guideline committees, payers, and academia. Discussions focused on identifying knowledge gaps in GLP-1RA use, evaluating how RWE informs practice, assessing limitations of real-world data, and strategies to reduce bias in RWE. Presentations emphasized RWE's potential to complement randomized trials by capturing rare adverse events, long-term outcomes, and effectiveness in routine care. However, persistent challenges include data reliability, confounding, and incomplete capture of medication use and outcomes, particularly in pediatric and underserved populations. Coverage decisions remain heterogeneous across Medicare, Medicaid, and private payers and across time, underscoring the need for rigorous cost-benefit analyses. The workshop concluded that robust RWE is essential for developing value-based coverage policies and optimizing GLP-1RA use. Continued investment in high-quality data infrastructure and analytic methods will be critical to inform regulatory, clinical, and economic decisions as utilization expands. FAU - Arterburn, David AU - Arterburn D AD - Kaiser Permanente Washington Health Research Institute, Seattle, Washington (D.A.). FAU - Curtis, Lesley H AU - Curtis LH AUID- ORCID: 0000-0002-3286-9371 AD - Duke University School of Medicine, Durham, North Carolina (L.H.C., D.D., A.S.). FAU - Toh, Sengwee AU - Toh S AUID- ORCID: 0000-0002-5160-0810 AD - Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts (S.T., D.R.W.). FAU - Bradley, Marie C AU - Bradley MC AD - U.S. Food and Drug Administration, Washington, DC (M.C.B.). FAU - D'Alessio, David AU - D'Alessio D AD - Duke University School of Medicine, Durham, North Carolina (L.H.C., D.D., A.S.). FAU - Duchovny, Noelia AU - Duchovny N AUID- ORCID: 0009-0004-5626-0589 AD - Congressional Budget Office, Washington, DC (N.D.). FAU - Hines, David AU - Hines D AUID- ORCID: 0009-0000-8288-0029 AD - Metro Nashville Public Schools, Nashville, Tennessee (D.H.). FAU - Narain, Kimberly AU - Narain K AUID- ORCID: 0000-0001-8548-1728 AD - University of California, Los Angeles, Los Angeles, California (K.N.). FAU - Parekh, Anand AU - Parekh A AD - University of Michigan School of Public Health, Ann Arbor, Michigan (A.P.). FAU - Skinner, Asheley AU - Skinner A AD - Duke University School of Medicine, Durham, North Carolina (L.H.C., D.D., A.S.). FAU - Wee, Christina C AU - Wee CC AD - Annals of Internal Medicine and American College of Physicians, Philadelphia, Pennsylvania (C.C.W.). FAU - Wong, John B AU - Wong JB AUID- ORCID: 0000-0003-4203-9010 AD - Tufts University School of Medicine, Boston, Massachusetts (J.B.W.). FAU - Wright, Davene R AU - Wright DR AUID- ORCID: 0000-0002-8574-4572 AD - Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts (S.T., D.R.W.). FAU - Osganian, Stavroula K AU - Osganian SK AD - National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland (S.K.O., C.H.). FAU - Hales, Craig AU - Hales C AUID- ORCID: 0000-0002-2355-1177 AD - National Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, Maryland (S.K.O., C.H.). LA - eng GR - K08 AG068372/AG/NIA NIH HHS/United States PT - Journal Article DEP - 20260630 PL - United States TA - Ann Intern Med JT - Annals of internal medicine JID - 0372351 RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) RN - 0 (Hypoglycemic Agents) SB - IM MH - Humans MH - United States MH - *Glucagon-Like Peptide-1 Receptor Agonists MH - *Hypoglycemic Agents/therapeutic use/economics/adverse effects MH - *Diabetes Mellitus, Type 2/drug therapy MH - *Insurance Coverage MH - National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) COIS- Disclosures: Disclosure forms are available with the article online. EDAT- 2026/06/29 22:36 MHDA- 2026/09/15 05:06 CRDT- 2026/06/29 17:03 PHST- 2026/09/15 05:06 [medline] PHST- 2026/06/29 22:36 [pubmed] PHST- 2026/06/29 17:03 [entrez] AID - 10.7326/ANNALS-25-05468 [doi] PST - ppublish SO - Ann Intern Med. 2026 Sep;179(9):1328-1337. doi: 10.7326/ANNALS-25-05468. Epub 2026 Jun 30. PMID- 42372031 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261008 IS - 1360-0451 (Electronic) IS - 0954-0121 (Linking) VI - 38 IP - 10 DP - 2026 Oct TI - Self-reported physical activity and associated health factors among individuals attending an urban HIV and sexual health clinic in the UK: a secondary analysis of a clinic-based cross-sectional survey. PG - 2137-2146 LID - 10.1080/09540121.2026.2686237 [doi] AB - Low levels of physical activity are associated with negative health consequences such as metabolic syndrome and depression, particularly among people living with HIV. Contemporary data on physical activity levels among people living with HIV in the United Kingdom are limited. In a cross-sectional survey, 280 respondents' (217 (78%) individuals living with and 62 (22%) without HIV) physical activity was assessed using the validated General Practice Physical Activity Questionnaire (GPPAQ). Socio-demographic characteristics and health factors were collected. A third of the respondents (33.21%) reported being physically active. Living with HIV (OR 0.35 (95%CI 0.19-0.62)), older age (OR 0.97 (95%CI 0.95-0.99)), Black ethnic background (OR 0.33 (95%CI 0.09-1.17)) and smoking (OR 0.55 (95%CI 0.27-1.11)) were associated with lower odds of being physically active in the univariate analyses. Risky alcohol consumption (OR 1.72 (95%CI 0.98-3.08)) and irregular dietary habits (OR 2.09 (95%CI 1.19-3.68)) were associated with being physically active. In the fully adjusted model, only the association between physical activity and HIVstatus persisted. Participants living with HIV were 59% less likely to report being physically active (adjusted OR 0.41, 95% CI 0.21-0.79). The low proportion of reported physical activity suggests a potential role for screening and guidance for exercise among HIV and sexual health clinic attendees. FAU - Bascombe, Florence AU - Bascombe F AUID- ORCID: 0000-0003-1005-6190 AD - Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London, United Kingdom. AD - The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom. FAU - Mcalpine, Connor AU - Mcalpine C AD - Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London, United Kingdom. AD - The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom. FAU - Milinkovic, Ana AU - Milinkovic A AD - Chelsea & Westminster Hospital NHS Foundation Trust, London, United Kingdom. FAU - Paredes, Jose Luis AU - Paredes JL AD - Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London, United Kingdom. AD - The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom. FAU - Matthews, Rebecca AU - Matthews R AD - Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London, United Kingdom. AD - The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom. FAU - Arenas-Pinto, Alejandro AU - Arenas-Pinto A AUID- ORCID: 0000-0002-3368-5005 AD - Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London, United Kingdom. AD - The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom. AD - MRC Clinical Trials Unit at UCL, London, United Kingdom. FAU - Suonpera, Emmi AU - Suonpera E AUID- ORCID: 0000-0001-9412-2516 AD - Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London, United Kingdom. AD - The Mortimer Market Centre, Central and North West London NHS Foundation Trust, London, United Kingdom. LA - eng PT - Journal Article DEP - 20260629 PL - England TA - AIDS Care JT - AIDS care JID - 8915313 SB - IM MH - Cross-Sectional Studies MH - *Exercise MH - United Kingdom MH - Self Report MH - Ambulatory Care Facilities/statistics & numerical data MH - *HIV Infections MH - *HIV Long-Term Survivors/statistics & numerical data MH - Surveys and Questionnaires MH - Health Behavior MH - Sexual Health MH - *Urban Health Services/statistics & numerical data MH - Socioeconomic Factors MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged OTO - NOTNLM OT - Cross-sectional OT - HIV OT - Physical activity OT - men who have sex with men OT - mental health EDAT- 2026/06/29 18:43 MHDA- 2026/10/07 17:33 CRDT- 2026/06/29 14:03 PHST- 2026/10/07 17:33 [medline] PHST- 2026/06/29 18:43 [pubmed] PHST- 2026/06/29 14:03 [entrez] AID - 10.1080/09540121.2026.2686237 [doi] PST - ppublish SO - AIDS Care. 2026 Oct;38(10):2137-2146. doi: 10.1080/09540121.2026.2686237. Epub 2026 Jun 29. PMID- 42371442 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260629 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 5 DP - 2026 May TI - Maternal Knowledge, Attitudes, and Practices Regarding Complementary Feeding Among Children Under 2 Years of Age: An Urban-Rural Comparison in Jharkhand, India. PG - e109844 LID - 10.7759/cureus.109844 [doi] LID - e109844 AB - Background Appropriate complementary feeding during the period of 6-24 months is essential for meeting the growing nutritional requirements of infants that cannot be met by breast milk alone after six months of age. Maternal knowledge, attitudes, and practices (KAP) are critical determinants of infant feeding behavior. Urban-rural disparities in education, socioeconomic status, and healthcare access may contribute to differences in these practices. This study aimed to assess and compare maternal KAP regarding complementary feeding in urban and rural areas of Ranchi district, Jharkhand, using a validated scoring framework. Methods A community-based cross-sectional study was conducted among 305 mothers of children aged 6-24 months in urban Doranda (n=107) and rural Ormanjhi (n=198), the field practice areas of the Department of Community Medicine, RIMS, Ranchi. Data were collected using a pre-tested semi-structured questionnaire. KAP was assessed using a Bloom's cut-off-based scoring system: knowledge scores were classified as good (>/=80%), moderate (60-79%), or poor (<60%); attitude as positive, neutral, or negative; and practice as good, moderate, or poor. Associations were tested using the chi-square test, and ORs were calculated to describe KAP pathways. Statistical significance was set at p<0.05. Results Overall, 63.3% of mothers had good knowledge, 58.0% held positive attitudes, and 54.1% demonstrated good complementary feeding practices. Urban mothers performed significantly better across all three domains (p=0.032, p=0.041, and p=0.006, respectively). Good knowledge was strongly associated with positive attitude (OR=5.35; 95% CI: 3.23-8.86; p<0.001) and good practice (OR=4.47; 95% CI: 2.60-7.68; p<0.001). Positive attitude showed the strongest association with good complementary feeding practices (OR=5.27; 95% CI: 3.05-9.11; p<0.001). Maternal education and household income were the most significant sociodemographic determinants of KAP (p<0.001 for both). Conclusion While general awareness was relatively high, significant gaps existed in practices, particularly in rural areas. The study demonstrates a sequential pathway from knowledge to attitude to practice, with socioeconomic factors as the primary underlying determinants. Targeted nutrition education and behavior change communication through frontline health workers are essential to translate knowledge into improved complementary feeding practices. CI - Copyright (c) 2026, Kiran et al. FAU - Kiran, Kumari Asha AU - Kiran KA AD - Preventive Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND. FAU - Priya, Neha AU - Priya N AD - Community Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND. FAU - Sunderam, Shalini AU - Sunderam S AD - Community Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND. FAU - Anit, Anuj K AU - Anit AK AD - Community Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND. FAU - Kumar, Dewesh AU - Kumar D AD - Community Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND. FAU - Kujur, Anit AU - Kujur A AD - Community Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND. LA - eng PT - Journal Article DEP - 20260528 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13310283 OTO - NOTNLM OT - behaviour change communication OT - bloom's classification OT - child nutrition OT - complementary feeding OT - jharkhand OT - kap pathway OT - maternal kap OT - urban-rural comparison COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee, Rajendra institute of Medical Sciences, Ranchi issued approval 312. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/06/29 12:32 MHDA- 2026/06/29 12:33 PMCR- 2026/05/28 CRDT- 2026/06/29 11:30 PHST- 2026/05/28 00:00 [accepted] PHST- 2026/06/29 12:33 [medline] PHST- 2026/06/29 12:32 [pubmed] PHST- 2026/06/29 11:30 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - 10.7759/cureus.109844 [doi] PST - epublish SO - Cureus. 2026 May 28;18(5):e109844. doi: 10.7759/cureus.109844. eCollection 2026 May. PMID- 42371394 OWN - NLM STAT- MEDLINE DCOM- 20260808 LR - 20260813 IS - 1573-6628 (Electronic) IS - 1092-7875 (Print) IS - 1092-7875 (Linking) VI - 30 IP - 7 DP - 2026 Jul TI - Multiple Output Gaussian Process Model for Predicting Low Birth Weight in Medellin, Colombia: An Alternative to Conventional Machine Learning Models. PG - 875-883 LID - 10.1007/s10995-026-04284-x [doi] AB - OBJECTIVE: To evaluate the methodological feasibility of a heterogeneous multi-output Gaussian process model for jointly handling a continuous birth outcome and its clinically used binary representation in routinely collected perinatal data, and to compare its predictive performance with that of conventional single-output models. METHODS: Routinely collected live-birth certificate data from Medellin, Colombia, covering births from 2012 to 2021, were analyzed. After cleaning and class balancing, the analytic dataset included 32,110 records. A heterogeneous multi-output Gaussian process model was trained to jointly model birth weight in grams with a Gaussian likelihood and low birth weight status with a Bernoulli likelihood. Predictive performance was compared with that of conventional single-output regression and classification models. RESULTS: The heterogeneous multi-output Gaussian process model achieved acceptable predictive performance (R(2) = 0.67 for birth weight and accuracy = 0.845 for low birth weight classification), with results comparable to those of models fitted separately for each task. These findings support the practical feasibility of modeling heterogeneous outputs within a single probabilistic framework. CONCLUSIONS: In this application, the heterogeneous multi-output Gaussian process model was a viable methodological alternative for jointly modeling birth weight in grams and its binary low-birth-weight classification. This study should be interpreted primarily as a methodological demonstration of a flexible multi-output framework in perinatal data that may be extended in future studies to jointly model other outcomes of greater direct relevance to public health. CI - (c) 2026. The Author(s). FAU - Salazar Blandon, Diego Alejandro AU - Salazar Blandon DA AUID- ORCID: 0000-0002-8724-7705 AD - School of Nursing, University of Antioquia, Medellin, Colombia. alejandro.salazar@udea.edu.co. FAU - Garcia Arias, Hernan Felipe AU - Garcia Arias HF AUID- ORCID: 0000-0002-2814-8838 AD - SISTEMIC research group, University of Antioquia, Medellin, Colombia. FAU - Giraldo Gutierrez, Juan Jose AU - Giraldo Gutierrez JJ AUID- ORCID: 0000-0002-9395-4289 AD - National Heart and Lung Institute, Imperial College London, London, UK. LA - eng PT - Journal Article DEP - 20260629 PL - United States TA - Matern Child Health J JT - Maternal and child health journal JID - 9715672 SB - IM MH - Humans MH - Colombia/epidemiology MH - *Infant, Low Birth Weight MH - *Machine Learning MH - Infant, Newborn MH - Predictive Learning Models MH - Normal Distribution MH - Female MH - Prediction Algorithms MH - Classification Algorithms MH - Birth Weight MH - Pregnancy MH - Birth Certificates MH - Models, Statistical PMC - PMC13451375 OTO - NOTNLM OT - Low birth weight OT - Machine learning OT - Models COIS- Declarations. Competing Interests: The authors declare that they have no competing interests. EDAT- 2026/06/29 12:33 MHDA- 2026/08/08 23:08 PMCR- 2026/06/29 CRDT- 2026/06/29 11:29 PHST- 2024/09/10 00:00 [received] PHST- 2026/05/16 00:00 [accepted] PHST- 2026/08/08 23:08 [medline] PHST- 2026/06/29 12:33 [pubmed] PHST- 2026/06/29 11:29 [entrez] PHST- 2026/06/29 00:00 [pmc-release] AID - 10.1007/s10995-026-04284-x [pii] AID - 4284 [pii] AID - 10.1007/s10995-026-04284-x [doi] PST - ppublish SO - Matern Child Health J. 2026 Jul;30(7):875-883. doi: 10.1007/s10995-026-04284-x. Epub 2026 Jun 29. PMID- 42370796 OWN - NLM STAT- Publisher LR - 20260629 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 Jun 29 TI - Food insecurity, nutrition, and mental health in children after earthquake exposure: Evidence from Turkiye. PG - 2601060261464033 LID - 10.1177/02601060261464033 [doi] AB - BackgroundChildren are particularly vulnerable to the psychological and nutritional consequences of natural disasters such as earthquakes. Understanding the relationship between mental health outcomes and food insecurity is essential for effective post-disaster interventions.ObjectivesThis study aimed to assess the prevalence of post-traumatic stress disorder (PTSD), anxiety, and depressive symptoms among children exposed to the 2023 earthquake in Turkiye, and to examine their nutritional status and household food security.MethodsA multicenter, cross-sectional survey was conducted between March and August 2025 among 782 children aged 6-17 years from twelve earthquake-affected provinces. Participants were recruited using stratified cluster sampling from schools and community health centers. Psychological outcomes were assessed using validated instruments (CPSS, SCARED, CDI). Nutritional status was evaluated using anthropometric measurements, dietary diversity indicators, and standardized food security scales.ResultsOverall, 21.7% of participants met the CPSS cut-off for probable PTSD, with a higher prevalence among girls. Anxiety symptoms were identified in 25.8% and depressive symptoms in 21.4% of children. Nutritional assessment showed that 11.3% were underweight and 18.6% were overweight or obese. Additionally, 40.3% of households experienced food insecurity.ConclusionMental health problems and nutritional vulnerability frequently co-occur among children after earthquake exposure. Integrated interventions addressing both psychological well-being and food security are essential to support recovery in disaster-affected populations. FAU - Arslan, Nurgul AU - Arslan N AUID- ORCID: 0000-0002-7618-0859 AD - Department of Nutrition and Dietetics, Ataturk Faculty of Health Sciences, Dicle University, Diyarbakir, Turkiye. RINGGOLD: 37507 LA - eng PT - Journal Article DEP - 20260629 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - Earthquakes OT - anxiety OT - children OT - depression OT - food security OT - mental health OT - nutritional status EDAT- 2026/06/29 12:33 MHDA- 2026/06/29 12:33 CRDT- 2026/06/29 09:43 PHST- 2026/06/29 12:33 [medline] PHST- 2026/06/29 12:33 [pubmed] PHST- 2026/06/29 09:43 [entrez] AID - 10.1177/02601060261464033 [doi] PST - aheadofprint SO - Nutr Health. 2026 Jun 29:2601060261464033. doi: 10.1177/02601060261464033. PMID- 42370479 OWN - NLM STAT- MEDLINE DCOM- 20260629 LR - 20260813 IS - 1365-277X (Electronic) IS - 0952-3871 (Print) IS - 0952-3871 (Linking) VI - 39 IP - 4 DP - 2026 Aug TI - Exploring Eating Patterns and Cooking Habits Among Emerging Adult College Students to Inform a Pilot Meal Kit Program. PG - e70299 LID - 10.1111/jhn.70299 [doi] LID - e70299 AB - INTRODUCTION: Emerging adult college students often experience poor diet quality (DQ) and rely heavily on ultra-processed foods (UPFs), such as sugary beverages, salty snacks, sweet snacks, and other calorie-dense, convenience foods. Meal kits, which provide pre-portioned ingredients and simple recipes, may offer a practical strategy to support healthier eating among emerging adults, yet their relevance and feasibility in college settings remain poorly understood. This study aims to assess the health behaviors, needs, and preferences of the target college student population to inform the development and feasibility of a pilot meal kit program. METHODS: This exploratory, community-informed research used a multi-method approach implemented in two phases: (1) an electronic survey of undergraduate students assessing sociodemographics, eating patterns, and meal preparation habits, and (2) virtual focus groups exploring protein intake, cooking behaviors, and desired meal-kit features. Quantitative data were analyzed using descriptive statistics, Pearson correlations, and logistic regression models. Qualitative data were coded using inductive thematic analysis. RESULTS: Students (N = 501) demonstrated low DQ (sHEI = 47.7 +/- 10.0/100), and 33.7% reported low or very low food security. Higher UPF intake (OR = 1.14, 95% CI [1.02, 1.25], p = 0.015), more frequent cooking (OR = 1.31, 95% CI [1.02, 1.70], p = 0.037), and greater food insecurity (OR = 1.08, 95% CI [1.003, 1.16], p = 0.042) significantly predicted interest in meal kits, although effect sizes were small (Nagelkerke R(2) = 0.015-0.023). Qualitative findings identified key barriers to healthy meal preparation, including limited time, inadequate kitchen access and equipment, financial constraints, and dissatisfaction with campus dining protein options. Students perceived meal kits as convenient and customizable but expressed concerns about affordability. CONCLUSION: Emerging adult college students face numerous barriers to healthy eating. Many view meal kits as a practical way to access convenient, nutritious meals. Affordable, culturally and economically tailored programs may help improve DQ and reduce reliance on UPFs. Findings support pilot testing a campus-based meal-kit program. CI - (c) 2026 The British Dietetic Association Ltd. FAU - Watras, Emma AU - Watras E AUID- ORCID: 0009-0003-4161-0024 AD - School of Food and Agriculture, University of Maine, Orono, Maine, USA. FAU - Mena, Noereem Z AU - Mena NZ AUID- ORCID: 0000-0002-7799-5566 AD - College of Life Sciences and Agriculture, University of New Hampshire, Durham, New Hampshire, USA. FAU - Strout, Kelley AU - Strout K AUID- ORCID: 0000-0002-2575-1041 AD - School of Nursing, University of Maine, Orono, Maine, USA. FAU - Gayer, Kayla AU - Gayer K AUID- ORCID: 0000-0002-9038-0152 AD - School of Food and Agriculture, University of Maine, Orono, Maine, USA. FAU - Yerxa, Kathryn AU - Yerxa K AUID- ORCID: 0000-0001-9510-6358 AD - Cooperative Extension, University of Maine, Orono, Maine, USA. FAU - McNamara, Jade AU - McNamara J AUID- ORCID: 0000-0003-3242-330X AD - School of Food and Agriculture, University of Maine, Orono, Maine, USA. LA - eng GR - National Pork Board/ PT - Journal Article PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Humans MH - Female MH - *Cooking/methods MH - *Students/psychology/statistics & numerical data MH - *Feeding Behavior/psychology MH - Young Adult MH - Universities MH - Pilot Projects MH - Male MH - *Meals/psychology MH - Adult MH - Food, Processed MH - *Diet, Healthy/psychology MH - Adolescent MH - Health Behavior MH - Food Preferences/psychology MH - Focus Groups MH - Fast Foods MH - Surveys and Questionnaires PMC - PMC13454157 OTO - NOTNLM OT - college students OT - cooking behaviors OT - diet quality OT - emerging adults OT - food insecurity OT - meal kits OT - ultra-processed foods COIS- The authors declare no conflicts of interest. EDAT- 2026/06/29 12:33 MHDA- 2026/06/29 12:34 PMCR- 2026/08/10 CRDT- 2026/06/29 07:23 PHST- 2026/05/27 00:00 [revised] PHST- 2026/02/19 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/06/29 12:34 [medline] PHST- 2026/06/29 12:33 [pubmed] PHST- 2026/06/29 07:23 [entrez] PHST- 2026/08/10 00:00 [pmc-release] AID - JHN70299 [pii] AID - 10.1111/jhn.70299 [doi] PST - ppublish SO - J Hum Nutr Diet. 2026 Aug;39(4):e70299. doi: 10.1111/jhn.70299. PMID- 42370059 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260629 LR - 20260813 IS - 2753-4294 (Electronic) IS - 2753-4294 (Linking) VI - 4 IP - 2 DP - 2026 TI - Identifying developmental vulnerability through linear growth screening: a UK cross-sectional study. PG - e004567 LID - 10.1136/bmjph-2025-004567 [doi] LID - e004567 AB - INTRODUCTION: Linear growth in early childhood is routinely measured in the UK, but it is unclear whether indicators of linear growth faltering can flag children with neurodevelopmental vulnerability, especially in ethnically diverse urban settings. We tested whether short stature (stunting) or being short for genetic potential identifies children at risk of failing routine developmental screening at age 2-2.5 years. METHODS: We conducted a cross-sectional analysis among 555 children aged 24-30 months (mean 26.0 months, SD 1.5) attending Healthy Child Programme reviews in East London. The sample was ethnically diverse, with substantial proportions of Bangladeshi, White and other minority ethnic groups. Developmental vulnerability was defined as scoring below the Ages and Stages Questionnaire, Third Edition (ASQ-3) cut-off in >/=1 domain. The exposures were stunting (height-for-age z score <-2 SD) and being short for genetic potential, defined as deviation from mid-parental height (DMPH) <-2 SD. Associations were examined using binomial multivariable logistic regression adjusted for age, sex, prematurity, maternal education, ethnicity and household benefits. A subset (n=94) completed the Griffiths III Mental Development Scales (GMDS-III) to validate ASQ-3 classification. RESULTS: Overall, 141/555 (25.4%) children screened positive for developmental vulnerability on the ASQ-3. Children with developmental vulnerability had significantly lower GMDS-III scaled scores across multiple domains supporting criterion validity. We did not find evidence of an association between stunting and developmental vulnerability (adjusted OR 1.35, 95% CI 0.47 to 3.49). In contrast, children who were short for genetic potential (DMPH <-2 SD) had higher odds of developmental vulnerability (adjusted OR 4.18, 95% CI 1.13 to 14.78). CONCLUSIONS: In this urban UK cohort, deviation from genetic height potential, rather than stunting, identified children at increased risk of developmental vulnerability. Incorporating parental heights into routine growth surveillance could offer a simple trigger for earlier neurodevelopmental review. CI - Copyright (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Papasavva, Michael AU - Papasavva M AUID- ORCID: 0000-0003-2111-9783 AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Orr, Joanna AU - Orr J AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Cordani, Isabella AU - Cordani I AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Oloko, Lola AU - Oloko L AD - Tower Hamlets GP Care Group CIC, London, UK. FAU - Hutchinson, Celes AU - Hutchinson C AD - Tower Hamlets GP Care Group CIC, London, UK. FAU - Norton, Christopher AU - Norton C AD - Tower Hamlets GP Care Group CIC, London, UK. FAU - Kamaljit, Kaur AU - Kamaljit K AD - Tower Hamlets GP Care Group CIC, London, UK. FAU - Freer, Joseph AU - Freer J AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Walton, Robert AU - Walton R AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Storr, Helen L AU - Storr HL AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Smuk, Melanie AU - Smuk M AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. FAU - Prendergast, Andrew J AU - Prendergast AJ AD - Faculty of Medicine and Dentistry, Queen Mary University of London, London, UK. LA - eng PT - Journal Article DEP - 20260623 PL - England TA - BMJ Public Health JT - BMJ public health JID - 9918697578906676 PMC - PMC13295896 OTO - NOTNLM OT - Humans OT - Public Health OT - Sociodemographic Factors COIS- None declared. EDAT- 2026/06/29 16:10 MHDA- 2026/06/29 16:11 PMCR- 2026/06/23 CRDT- 2026/06/29 07:03 PHST- 2025/11/19 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/06/29 16:11 [medline] PHST- 2026/06/29 16:10 [pubmed] PHST- 2026/06/29 07:03 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - bmjph-2025-004567 [pii] AID - 10.1136/bmjph-2025-004567 [doi] PST - epublish SO - BMJ Public Health. 2026 Jun 23;4(2):e004567. doi: 10.1136/bmjph-2025-004567. eCollection 2026. PMID- 42369304 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260629 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Mood changes of children and adolescents in dance classes: a prospective repeated-measures study. PG - 1719704 LID - 10.3389/fpsyg.2026.1719704 [doi] LID - 1719704 AB - INTRODUCTION: Adolescent mental health in the United States has deteriorated markedly over the past decade, with diagnosed mental or behavioral health conditions among 12-to-17-year-olds increasing 35% between 2016 and 2023, driven by a 61% rise in anxiety diagnoses and a 45% rise in depression. Community-based interventions combining physical activity, creative expression, and social connection represent a promising response. METHODS: This prospective repeated-measures study examined the association between structured dance education and mood among 256 children and adolescents (ages 5-17) at four studio locations. Over 4 months (February-May 2025), students completed 4,224 paired pre- and post-class mood ratings using a single-item emoji scale; the primary analytic sample comprised 4,059 sessions from 251 students. PANAS-C administrations provided a concurrent measure of dispositional affect, with each student's score anchored to the administration nearest the study close. Multilevel models accounted for the nested data structure (students contributing 1-109 sessions each). RESULTS: The intraclass correlation was 0.432. Post-class mood was significantly higher than pre-class mood (session-level Cohen's d = 0.27 [primary estimate] and per-student d_z = 0.43 [p < 0.001]) with 85.8% of sessions showing maintained or improved mood. A Tobit sensitivity analysis confirmed these patterns after adjusting for the 28.8% post-class ceiling rate. No covariate (including weekly frequency, class type, proficiency level, or instructor experience) explained significant additional variance. Individual differences dominated: random slopes improved model fit substantially (DeltaAIC = 201). Convergent validity between the emoji scale and PANAS-C Positive Affect was significant (r = 0.19, p = 0.011, n = 175), with the strongest association among students attending 4-6 classes per week (r = 0.51, n = 25). CONCLUSION: Dance participation was associated with a consistent acute mood benefit generalizing across genres, schedules, and experience levels; individual characteristics, rather than program features, accounted for most meaningful variation. The observational design precludes causal attribution. CI - Copyright (c) 2026 Henderson, Henderson, Robertson-Kraft and Levick. FAU - Henderson, Tiffany C AU - Henderson TC AD - Master of Applied Positive Psychology Program, University of Pennsylvania, Philadelphia, PA, United States. AD - Tiffany's Dance Academy, Livermore, CA, United States. FAU - Henderson, Paul R AU - Henderson PR AD - Raising the Barre, Livermore, CA, United States. FAU - Robertson-Kraft, Claire AU - Robertson-Kraft C AD - Master of Applied Positive Psychology Program, University of Pennsylvania, Philadelphia, PA, United States. FAU - Levick, Judy Saltzberg AU - Levick JS AD - Master of Applied Positive Psychology Program, University of Pennsylvania, Philadelphia, PA, United States. LA - eng PT - Journal Article DEP - 20260611 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13293843 OTO - NOTNLM OT - PANAS-C OT - children and adolescents OT - dance education OT - ecological momentary assessment OT - mood OT - multilevel modeling OT - positive psychology OT - well-being COIS- TH and PH are co-founders of Tiffany's Dance Academy, a for-profit dance studio business, and Raising the Barre, a 501(c)(3) youth-service nonprofit organization, both based in Livermore, CA, USA. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/29 12:32 MHDA- 2026/06/29 12:33 PMCR- 2026/06/11 CRDT- 2026/06/29 06:56 PHST- 2025/10/06 00:00 [received] PHST- 2026/04/14 00:00 [revised] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/06/29 12:33 [medline] PHST- 2026/06/29 12:32 [pubmed] PHST- 2026/06/29 06:56 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1719704 [doi] PST - epublish SO - Front Psychol. 2026 Jun 11;17:1719704. doi: 10.3389/fpsyg.2026.1719704. eCollection 2026. PMID- 42368948 OWN - NLM STAT- MEDLINE DCOM- 20260629 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Formal uniforms as an environmental constraint on NEAT and adolescent obesity: a cross-sectional study in boarding schools. PG - 1817702 LID - 10.3389/fpubh.2026.1817702 [doi] LID - 1817702 AB - BACKGROUND: The rising prevalence of obesity in adolescents is commonly attributed to a decrease in moderate to vigorous physical activity (MVPA), but the role of environmental constraints on thermogenesis from non-exercise activities (NEAT) remains under-explored. School uniforms are a daily necessity and may be associated with physical or perceived barriers to spontaneous low-intensity movement. This study investigated the relationship between type of school uniform (formal versus athletic) and body mass index (BMI) and examined whether NEAT-related behaviors showed a statistical mediation pattern in a gender-specific manner. METHOD: A cross-sectional study was conducted in four 100 percent boarding secondary schools in China. A total of 1,068 adolescents were stratified by mandatory uniform type. NEAT-related behaviors were assessed using an adapted self-reported questionnaire and compared with accelerometry-derived metrics in a sedentary validation sub-sample (n = 108). Mediation analyses and moderated mediation analyses were conducted to examine the uniform type, NEAT-related behaviors, and BMI associations. RESULTS: Formal uniforms were significantly associated with higher BMI in women (Delta = 0.7 kg/m(2), p < 0.01) but not in men (p > 0.05). Mediation analyses suggested that this association was statistically mediated by lower NEAT-related behaviors [beta_indirect = 0.123, 95% CI (0.054, 0.208)], accounting for 60.3% of the total effect. Exploratory subgroup analyses showed a larger uniform-BMI difference among students in the lowest NEAT-related activity decile: in the lowest decile of sedentary behavior, the difference in body mass index between homogeneous groups widened from a negligible amount in highly active girls to a larger observed difference of 1.3 kg/m(2) (p < 0.01). CONCLUSION: Formal school uniforms were associated with lower NEAT-related movement and higher body mass index in adolescent females in this study population. This relationship was more pronounced among students with lower baseline activity levels, suggesting that restrictive clothing may act as an environmental constraint on spontaneous low-intensity movement. These findings suggest that movement-friendly school uniform designs may warrant further investigation in residential school settings. CI - Copyright (c) 2026 Wang, Lin, Zhang and Liu. FAU - Wang, Yuan AU - Wang Y AD - School Uniform Management Professional Committee, China Association for Campus Management, Beijing, China. FAU - Lin, Rubing AU - Lin R AD - Department of Orthopedics, Shenzhen Children's Hospital, Shenzhen, China. FAU - Zhang, Wei AU - Zhang W AD - Department of Clinical Laboratory, Peking University Shenzhen Hospital, Shenzhen, China. FAU - Liu, Yantong AU - Liu Y AD - Department of Clinical Laboratory, Peking University Shenzhen Hospital, Shenzhen, China. AD - Department of Computer and Information Engineering, Kunsan National University, Gunsan, Republic of Korea. LA - eng PT - Journal Article DEP - 20260612 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - Adolescent MH - Body Mass Index MH - China/epidemiology MH - *Schools MH - *Pediatric Obesity/epidemiology MH - *Clothing/statistics & numerical data MH - *Thermogenesis/physiology MH - *Exercise/physiology MH - Accelerometry PMC - PMC13303609 OTO - NOTNLM OT - adolescent obesity OT - environmental constraint OT - gender disparity OT - non-exercise activity thermogenesis (NEAT) OT - school uniforms OT - sedentary behavior COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/29 16:10 MHDA- 2026/06/29 16:11 PMCR- 2026/06/12 CRDT- 2026/06/29 06:52 PHST- 2026/02/25 00:00 [received] PHST- 2026/05/04 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/29 16:11 [medline] PHST- 2026/06/29 16:10 [pubmed] PHST- 2026/06/29 06:52 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1817702 [doi] PST - epublish SO - Front Public Health. 2026 Jun 12;14:1817702. doi: 10.3389/fpubh.2026.1817702. eCollection 2026. PMID- 42368298 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260629 LR - 20260926 IS - 1687-8728 (Print) IS - 1687-8736 (Electronic) IS - 1687-8728 (Linking) VI - 2026 DP - 2026 TI - Morphological Study of the Characteristics of Lips in Children With Mouth Breathing. PG - 1585193 LID - 10.1155/ijod/1585193 [doi] LID - 1585193 AB - OBJECTIVE: This study aimed to explore the association between long-term mouth breathing habits and the morphological characteristics of children's lips, providing a basis for clinical diagnosis and early intervention. Given the cross-sectional design and reliance on parental questionnaire-based exposure classification, causal inference is not warranted; findings are strictly associative. METHODS: A total of 210 children aged 6-12 years were enrolled, comprising 105 children clinically classified as long-term mouth-breathing children and 105 nasal-breathing children. Classification was based on a validated parental questionnaire with defined major and minor signs; objective airway assessment was not performed, which is acknowledged as a limitation. Lip morphological characteristics were analyzed from standardized lateral cephalograms. Quantitative parameters included protrusion of the subnasal region, upper lip, lower lip, and chin; length of the upper lip, lower lip, and chin; the ratio of upper lip length to lower lip length; nasolabial angle; mentolabial angle. Comparisons between groups used independent-samples t-tests with covariate adjustment (analysis of covariance [ANCOVA]) for age, sex, and BMI, and the Benjamini-Hochberg false discovery rate (FDR) correction for multiple comparisons. Effect sizes (Cohen's d) and 95% confidence intervals (CIs) are reported. RESULTS: Significant positive correlations were found among Ns to N' Vert, UL to N' Vert, LL to N' Vert, Pog' to N' Vert, UL-L, LL-L, and Cn-L. Compared with nasal-breathing children, mouth-breathing children showed decreased protrusion of the subnasal region and upper lip, retraction of the chin, a sharper nasolabial angle, and a more obtuse mentolabial angle. No significant difference in lower lip protrusion (LL to N' Vert) was found between groups (adjusted p = 0.225). Because all participants were recruited from an orthodontic clinic, these findings may not be generalizable to the general pediatric population. CONCLUSIONS: Mouth breathing is associated with significant differences in lip and facial soft-tissue morphology in children, particularly in the protrusion and length of the subnasal region, upper lip, and chin, as well as in nasolabial and mentolabial angles. Early identification and interdisciplinary management of mouth breathing may be important for preventing further morphological changes; however, longitudinal studies are needed to establish temporal relationships and causal mechanisms. CI - Copyright (c) 2026 Lu Wenting et al. International Journal of Dentistry published by John Wiley & Sons Ltd. FAU - Wenting, Lu AU - Wenting L AUID- ORCID: 0009-0000-3613-0550 AD - Department of Orthodontics, Shanghai Ninth Peoples' Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China, shsmu.edu.cn. FAU - Xiaowei, Wu AU - Xiaowei W AUID- ORCID: 0009-0000-7248-839X AD - Department of Orthodontics, Shanghai Ninth Peoples' Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China, shsmu.edu.cn. FAU - Shengdan, Yu AU - Shengdan Y AD - Department of Orthodontics, Shanghai Ninth Peoples' Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China, shsmu.edu.cn. FAU - Xin, Yan AU - Xin Y AD - Department of Orthodontics, Shanghai Ninth Peoples' Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China, shsmu.edu.cn. FAU - Mengyuan, Guo AU - Mengyuan G AD - Department of Orthodontics, Shanghai Ninth Peoples' Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China, shsmu.edu.cn. FAU - Lili, Hou AU - Lili H AUID- ORCID: 0000-0001-6489-1744 AD - Department of Nursing, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China, shsmu.edu.cn. FAU - Xiaogang, Pan AU - Xiaogang P AUID- ORCID: 0000-0001-8623-4526 AD - Department of Orthodontics, Shanghai Ninth Peoples' Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, 200011, China, shsmu.edu.cn. LA - eng PT - Journal Article DEP - 20260626 PL - United States TA - Int J Dent JT - International journal of dentistry JID - 101524183 EIN - Int J Dent. 2026 Aug 11;2026:9769151. doi: 10.1155/ijod/9769151. PMID: 42591848 PMC - PMC13306110 OTO - NOTNLM OT - children OT - early intervention OT - lip morphological characteristics OT - mouth breathing COIS- The authors declare no conflicts of interest. EDAT- 2026/06/29 12:32 MHDA- 2026/06/29 12:33 PMCR- 2026/06/26 CRDT- 2026/06/29 06:46 PHST- 2025/05/20 00:00 [received] PHST- 2026/04/28 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/29 12:33 [medline] PHST- 2026/06/29 12:32 [pubmed] PHST- 2026/06/29 06:46 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - IJOD1585193 [pii] AID - 10.1155/ijod/1585193 [doi] PST - epublish SO - Int J Dent. 2026 Jun 26;2026:1585193. doi: 10.1155/ijod/1585193. eCollection 2026. PMID- 42366751 OWN - NLM STAT- Publisher LR - 20260629 IS - 1469-672X (Electronic) IS - 0264-6838 (Linking) DP - 2026 Jun 28 TI - Interpersonal psychotherapy for adolescent gestational weight gain and wellbeing: pilot and feasibility randomised controlled trial. PG - 1-17 LID - 10.1080/02646838.2026.2694056 [doi] AB - AIMS/BACKGROUND: Pregnant adolescents face adversities that heighten perinatal complications in mental (e.g. depression) and physical (e.g. excess gestational weight gain [GWG]) health. Depression may affect excess GWG through stress-related behaviours. We sought to pilot feasibility/acceptability of integrating a brief mental health intervention within prenatal care to address depression and stress-related behaviours contributing to excess GWG. DESIGN/METHODS: The current study reports recruitment/retention, feasibility, and intervention/protocol acceptability of a pilot randomised controlled trial with N = 37 pregnant 13-19-year-olds receiving multidisciplinary prenatal care (NCT03086161). Participants were randomised to 6 x 1-hour individual interpersonal psychotherapy sessions plus usual multidisciplinary prenatal care (IPT+UC) or usual care only (UC). Feasibility was tracked using CONSORT flow. Adolescents completed acceptability ratings at post-program. Within-condition and between-group changes in social functioning, depression, stress-related behaviours, and GWG were assessed from baseline to mid-programme and post-programme. RESULTS: 88% of potentially eligible patients enrolled. At mid-programme, 43% were retained in IPT+UC versus 38% in UC; at post-program 38% were retained in IPT+UC versus 35% in UC. Within IPT+UC, 47% received >/= 80% IPT dosage. Adolescents rated IPT acceptability above-average. Within-group, IPT+UC showed decreased mother-adolescent negative interactions at mid-programme (r = .76, p = .01) and post-programme (r = .63, p = .04). There was no difference in gestational weight gain between arms (epsilon(2) = .02, p = .87). CONCLUSION: Brief, integrated mental health therapy in multidisciplinary prenatal care for adolescents has feasible enrolment and may offer an acceptable approach for mental-physical health. Dosage and retention require refinement. Incorporating dissemination/implementation science principles is warranted in future tests of IPT to support the mental-physical health of pregnant adolescents. FAU - Joslin, Steffany AU - Joslin S AD - Department of Human Development and Family Studies, Colorado State University, Fort Collins, CO, USA. AD - Department of Pediatrics, Section of Endocrinology, University of Colorado Anschutz and Children's Hospital Colorado, Aurora, CO, USA. FAU - Gulley, Lauren D AU - Gulley LD AD - Department of Pediatrics, Section of Endocrinology, University of Colorado Anschutz and Children's Hospital Colorado, Aurora, CO, USA. FAU - Pyle, Laura AU - Pyle L AD - Division of Metabolism, Endocrinology, and Nutrition, University of Washington School of Medicine, Seattle, WA, USA. FAU - Clark, Emma L M AU - Clark ELM AD - Department of Human Development and Family Studies, Colorado State University, Fort Collins, CO, USA. FAU - Tanofsky-Kraff, Marian AU - Tanofsky-Kraff M AD - Department of Medical and Clinical Psychology, Uniformed Services University, Bethesda, MD, USA. FAU - Nadeau, Kristen J AU - Nadeau KJ AD - Department of Pediatrics, Section of Endocrinology, University of Colorado Anschutz and Children's Hospital Colorado, Aurora, CO, USA. FAU - Barbour, Linda A AU - Barbour LA AD - Department of Medicine, University of Colorado Anschutz, Aurora, CO, USA. AD - Department of Obstetrics and Gynecology, University of Colorado Anschutz, Aurora, CO, USA. FAU - Scott, Stephen M AU - Scott SM AD - Department of Medicine, University of Colorado Anschutz, Aurora, CO, USA. AD - Department of Obstetrics and Gynecology, University of Colorado Anschutz, Aurora, CO, USA. FAU - Sheeder, Jeanelle L AU - Sheeder JL AD - Department of Medicine, University of Colorado Anschutz, Aurora, CO, USA. AD - Department of Obstetrics and Gynecology, University of Colorado Anschutz, Aurora, CO, USA. FAU - Shomaker, Lauren B AU - Shomaker LB AD - Department of Human Development and Family Studies, Colorado State University, Fort Collins, CO, USA. AD - Department of Pediatrics, Section of Endocrinology, University of Colorado Anschutz and Children's Hospital Colorado, Aurora, CO, USA. AD - Department of Community and Behavioral Health, Colorado School of Public Health, Aurora, CO, USA. LA - eng PT - Journal Article DEP - 20260628 PL - England TA - J Reprod Infant Psychol JT - Journal of reproductive and infant psychology JID - 8501885 SB - IM OTO - NOTNLM OT - Interpersonal psychotherapy OT - adolescence OT - depression OT - obesity, pregnancy EDAT- 2026/06/29 06:30 MHDA- 2026/06/29 06:30 CRDT- 2026/06/29 02:44 PHST- 2026/06/29 06:30 [medline] PHST- 2026/06/29 06:30 [pubmed] PHST- 2026/06/29 02:44 [entrez] AID - 10.1080/02646838.2026.2694056 [doi] PST - aheadofprint SO - J Reprod Infant Psychol. 2026 Jun 28:1-17. doi: 10.1080/02646838.2026.2694056. PMID- 42366551 OWN - NLM STAT- Publisher LR - 20260629 IS - 1464-5165 (Electronic) IS - 0963-8288 (Linking) DP - 2026 Jun 28 TI - Group-based aquatic exercise for adolescents with down syndrome; a pilot study. PG - 1-11 LID - 10.1080/09638288.2026.2691633 [doi] AB - PURPOSE: Adolescents with Down syndrome (ADS) have reduced physical activity (PA) levels compared to peers. Aquatic exercise may appeal to ADS because the aquatic environment allows for increased ease of movement and mobility. However, research surrounding group-based aquatic exercise programs for ADS is limited. The purpose of the study was to investigate the safety, feasibility, and preliminary outcomes of group-based aquatic exercise for ADS. MATERIALS AND METHODS: Nine ADS, participated in a twice-weekly, one-hour group-based aquatic exercise class over eight weeks. Safety was assessed via heart rate monitoring and critical incidents. Feasibility was assessed through program adherence and parent perception of convenience. Outcome measures included the timed up-and-go test (TUG), five-repetition sit-to-stand test (FRSTST), six-minute walk test (6MWT), pediatric quality of life inventory (PedsQL TM), and a parent satisfaction survey. Scores were compared with pre- and post-intervention and at 4-week follow-up. RESULTS: There were no critical safety incidents. Program adherence was > 85%. Improvements in the 6MWT and the PedsQL TM were found (p < .017). Improvements exceeding the minimal detectable change were obtained for the 6MWT, TUG, FRSTST, and PedsQL TM. Parent satisfaction was high. CONCLUSION: Group-based aquatic exercise may provide a safe, feasible and effective alternative to PA in ADS. FAU - Conklin, Ashley B AU - Conklin AB AD - The Department of Rehabilitation and Movement Sciences at Rutgers, The State University of New Jersey. Rutgers University, Newark, NJ, USA. FAU - Martin, Kathy AU - Martin K AD - The Krannert School of Physical Therapy at The University of Indianapolis, The University of Indianapolis, Indianapolis, IN, USA. FAU - Ennis, Beth AU - Ennis B AD - Currently unaffiliated. FAU - Moore, Elizabeth AU - Moore E AD - The College of Health Sciences at The University of Indianapolis, The University of Indianapolis, Indianapolis, IN, USA. LA - eng PT - Journal Article DEP - 20260628 PL - England TA - Disabil Rehabil JT - Disability and rehabilitation JID - 9207179 SB - IM OAB - Adolescents with Down syndrome have reduced physical activity levels compared to their typically developing peers, placing them at higher risk of health-related complications and a sedentary lifestyle.A twice-weekly, 1-hour aquatic exercise program incorporating moderate intensity aerobic exercise and strength maneuvers was implemented with nine adolescents with Down syndrome over an 8 week period.The aquatic exercise program was safe, feasible and well received by all participants, with high levels of parent satisfaction reported.Despite the relatively small sample size, the preliminary results of this pilot study support the implementation of group-based aquatic exercise as a means of improving both social and physical health and well-being for adolescents with Down syndrome. OABL- eng OTO - NOTNLM OT - Down syndrome OT - adolescents OT - aquatic exercise OT - group exercise OT - physical activity EDAT- 2026/06/29 06:30 MHDA- 2026/06/29 06:30 CRDT- 2026/06/29 01:02 PHST- 2026/06/29 06:30 [medline] PHST- 2026/06/29 06:30 [pubmed] PHST- 2026/06/29 01:02 [entrez] AID - 10.1080/09638288.2026.2691633 [doi] PST - aheadofprint SO - Disabil Rehabil. 2026 Jun 28:1-11. doi: 10.1080/09638288.2026.2691633. PMID- 42366411 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260917 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jun 29 TI - A prospective longitudinal interventional cohort study on maternal nutrition and pregnancy outcomes in urban Cameroon (CAMELIA): study protocol. LID - 10.1186/s12884-026-09536-w [doi] LID - 1017 AB - BACKGROUND: Maternal nutritional exposures during pregnancy are critical determinants of maternal and neonatal outcomes, yet remain inadequately characterized in many African settings, including Cameroon. The CAMELIA (Cameroon Maternal and Early Life Assessment) cohort aims to evaluate maternal nutritional status early in pregnancy, implement a structured nutritional intervention, and assess its impact on maternal, neonatal, and long-term metabolic outcomes. METHODS: CAMELIA is a prospective, longitudinal interventional cohort enrolling 1,200 pregnant women at less than 22 weeks' gestation in an urban primary healthcare facility in Cameroon (Hopital Monseigneur Jean Zoa, Yaounde). Participants are recruited at the first antenatal visit and followed through delivery and up to 42 days postpartum. Data and biological samples are collected across four visits: at enrolment (< 22 weeks), between 24 and 32 weeks of gestation, at delivery, and at 42 days postpartum. A structured multi-modal nutritional intervention (SUN-APP program) is initiated at enrolment, delivered through individual counselling, group education, monthly interactive workshops, and digital health support via weekly WhatsApp and SMS messages. Gestational hyperglycaemia is screened using fasting capillary blood glucose at V1 and V2, applying a threshold of >/= 92 mg/dL. Primary outcomes are feasibility and acceptability of the intervention. Secondary outcomes include prevalence of gestational hyperglycaemia, hypertensive disorders, anaemia, low birth weight, and preterm birth. The study holds ethical approval from the Cameroon National Ethics Committee (CNERSH; approval no. 2025/04/1790/CE/CNERSH/SP) and is registered in the ISRCTN registry (ISRCTN13961105). CONCLUSIONS: The CAMELIA study provides a scalable and replicable framework for embedding structured nutritional risk screening and targeted interventions into routine antenatal care in a low-resource African setting. Findings will inform strategies for the prevention of gestational metabolic disorders and adverse perinatal outcomes across generations. TRIAL REGISTRATION: ISRCTN13961105. Registered 14 August 2025. CI - (c) 2026. The Author(s). FAU - Zemsi, Sylvain AU - Zemsi S AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. AD - Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon. FAU - Ekwoge, Diane AU - Ekwoge D AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. AD - Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon. FAU - Saha, Brice AU - Saha B AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. AD - Faculty of Biochemistry, University of Bamenda, Bamenda, Cameroon. FAU - Kalla, Valdes AU - Kalla V AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. AD - Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon. FAU - Minkam, Azalee AU - Minkam A AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. FAU - Ayeni, Doris AU - Ayeni D AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. AD - Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon. FAU - Tsanga, Michel AU - Tsanga M AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. FAU - Ndi, Jean Arnaud AU - Ndi JA AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. FAU - Powo, Arnold AU - Powo A AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. FAU - Baban, Thierry AU - Baban T AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. AD - Toulouse National Polytechnique Institute, Toulouse, France. FAU - Guewo, Magellan AU - Guewo M AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. AD - Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon. FAU - Katte, Jean Claude AU - Katte JC AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. AD - University of Exeter, Exeter, UK. FAU - Ondobo, Xavier AU - Ondobo X AD - Hopital Monseigneur Jean Zoa de Nkolndongo, Yaounde, Cameroon. FAU - Sobngwi-Tambekou, Joelle AU - Sobngwi-Tambekou J AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. FAU - Fezeu, Leopold AU - Fezeu L AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. AD - Universite Sorbonne Paris Nord and Universite Paris Cite, INSERM, INRAE, CNAM, Centre for Research in Epidemiology and Statistics (CRESS), Nutritional Epidemiology Research Team (EREN), Bobigny, F-93017, France. FAU - Sobngwi, Eugene AU - Sobngwi E AD - RSD Institute, Rue de l'Universite, Yaounde, Cameroon. eugenesobngwi@gmail.com. AD - Faculty of Medicine and Biomedical Sciences, University of Yaounde 1, Yaounde, Cameroon. eugenesobngwi@gmail.com. LA - eng PT - Journal Article DEP - 20260629 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Cameroon/epidemiology MH - Prospective Studies MH - *Pregnancy Outcome MH - Longitudinal Studies MH - Adult MH - *Maternal Nutritional Physiological Phenomena MH - Infant, Newborn MH - *Nutritional Status MH - *Prenatal Care/methods MH - *Pregnancy Complications/epidemiology MH - Premature Birth/epidemiology MH - Diabetes, Gestational/epidemiology MH - Urban Population PMC - PMC13576244 OTO - NOTNLM OT - Africa OT - Cameroon OT - Cohort study OT - Environmental exposure OT - Gestational diabetes OT - Hypertensive disorders OT - Maternal health OT - Neonatal outcomes OT - Nutrition OT - Pregnancy COIS- Declarations. Ethics approval and consent to participate: The CAMELIA study received ethical clearance from the National Ethics Committee for Research in Human Health (CNERSH) of Cameroon (approval no. 2025/04/1790/CE/CNERSH/SP). Written informed consent is obtained from all participants. For participants under 21 years of age, written parental consent and participant assent are required. All study procedures are conducted in accordance with Good Clinical Practice (ICH-GCP) and the Declaration of Helsinki. All information collected is kept strictly confidential. Participants are identified by a unique coded number; no names, addresses, or telephone numbers are disclosed to any researcher outside the core study team. Records and samples are securely archived for future research. Participants have explicitly consented to the storage of biological samples (blood and urine, including umbilical cord blood) in the RSD Institute biobank and to their use in future ethically approved research studies. The study protocol, information sheets, and consent forms have been submitted to the CNERSH for approval and remain subject to review for any substantial amendments. Any amendments will be communicated to the ISRCTN registry within 15 days. Competing interests: The authors declare no competing interests. EDAT- 2026/06/29 04:10 MHDA- 2026/09/15 05:36 PMCR- 2026/06/29 CRDT- 2026/06/28 23:25 PHST- 2026/05/21 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/09/15 05:36 [medline] PHST- 2026/06/29 04:10 [pubmed] PHST- 2026/06/28 23:25 [entrez] PHST- 2026/06/29 00:00 [pmc-release] AID - 10.1186/s12884-026-09536-w [pii] AID - 9536 [pii] AID - 10.1186/s12884-026-09536-w [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jun 29;26(1):1017. doi: 10.1186/s12884-026-09536-w. PMID- 42365611 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260706 IS - 1471-2865 (Electronic) IS - 1358-2267 (Linking) VI - 31 IP - 3 DP - 2026 Jul TI - Reliability of Pressure Pain Threshold Measurements of Upper and Lower Limb Muscles of Young Swimmers: An Observational Study. PG - e70262 LID - 10.1002/pri.70262 [doi] AB - BACKGROUND AND PURPOSE: Objective measures should be combined with subjective assessments to monitor pain and discomfort, particularly in sports with a high prevalence of atraumatic injuries. Therefore, this study aimed to determine the reliability of pressure pain threshold (PPT) measurements in competitive swimmers and to explore the influence of intrinsic and extrinsic factors on PPT. METHODS: Forty-seven swimmers were included in the study. PPT was measured bilaterally in 10 muscles of the upper and lower limbs and trunk using a hand-held algometer. Two trained physiotherapists performed four consecutive evaluations on the same day, with a 5-min interval between repeated measures, in randomized order to minimize carryover effects. Intrinsic variables included age, body mass index, shoulder pain, injury history, and years of practice. Extrinsic variables included swimming style, swimming distance, competitive level, training frequency, and training duration. Reliability was assessed using intraclass correlation coefficients, standard error of measurement, minimal detectable change, and coefficient of variation. The influence of intrinsic and extrinsic factors on PPT was explored using multivariate analysis of variance. RESULTS: Reliability varied from good to excellent across all muscles, with ICC values between 0.75 and 0.95. Descriptive data indicated that swimmers competing at the national level had higher PPT values compared with regional/state athletes, and butterfly specialists showed slightly higher PPTs. Across all participants, lower limb muscles consistently exhibited higher PPT values than upper limb muscles (e.g., rectus femoris mean 4.2 kg/cm(2) vs. biceps brachii mean 2.8 kg/cm(2)). CONCLUSIONS: Reliability was high across all muscles, and PPT differences observed appear to reflect training level, stroke specialization, and muscle group characteristics rather than intrinsic or injury-related factors. Furthermore, applications up to 5 kgf are safe and well tolerated in the lower limb, which differs from the usual threshold of 2.55 kgf commonly used in the upper limb. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Carrion Caldeira Ribeiro, Gabriela AU - Carrion Caldeira Ribeiro G AUID- ORCID: 0000-0002-5952-7603 AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. FAU - Alves de Carvalho, Flavia AU - Alves de Carvalho F AUID- ORCID: 0000-0002-2740-4959 AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. FAU - Paes de Lima, Heloisa AU - Paes de Lima H AUID- ORCID: 0000-0002-1460-0141 AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. FAU - Moreira de Castro Pereira Perez Espinoza, Rafael AU - Moreira de Castro Pereira Perez Espinoza R AUID- ORCID: 0000-0002-8167-7448 AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. FAU - Machado da Silva, Isaque AU - Machado da Silva I AUID- ORCID: 0009-0002-8339-7287 AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. FAU - Zacharias de Souza, Ricardo AU - Zacharias de Souza R AUID- ORCID: 0009-0003-6411-017X AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. FAU - Pastre, Carlos Marcelo AU - Pastre CM AUID- ORCID: 0000-0002-0213-6679 AD - Department of Physiotherapy, Sao Paulo State University, Sao Paulo, Brazil. LA - eng GR - 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ PT - Journal Article PT - Observational Study PL - United States TA - Physiother Res Int JT - Physiotherapy research international : the journal for researchers and clinicians in physical therapy JID - 9612022 SB - IM MH - Humans MH - *Swimming/physiology MH - Female MH - Reproducibility of Results MH - Male MH - *Pain Threshold/physiology MH - Adolescent MH - *Upper Extremity/physiology/physiopathology MH - *Pain Measurement/methods MH - *Lower Extremity/physiology MH - *Muscle, Skeletal/physiopathology MH - Pressure OTO - NOTNLM OT - muscle sensitivity OT - pressure algometry OT - swimmer EDAT- 2026/06/28 18:30 MHDA- 2026/06/28 18:31 CRDT- 2026/06/28 13:22 PHST- 2026/06/09 00:00 [revised] PHST- 2024/11/06 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/06/28 18:31 [medline] PHST- 2026/06/28 18:30 [pubmed] PHST- 2026/06/28 13:22 [entrez] AID - 10.1002/pri.70262 [doi] PST - ppublish SO - Physiother Res Int. 2026 Jul;31(3):e70262. doi: 10.1002/pri.70262. PMID- 42365345 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260915 LR - 20260917 IS - 1477-9560 (Print) IS - 1477-9560 (Electronic) IS - 1477-9560 (Linking) VI - 24 IP - 1 DP - 2026 Jun 27 TI - Association between D-dimer difference and risk of postoperative venous thromboembolism in endometrial cancer: a retrospective cohort study. LID - 10.1186/s12959-026-00893-2 [doi] LID - 84 AB - OBJECTIVE: To investigate the association between D-dimer level changes and venous thromboembolism (VTE) risk in endometrial cancer patients undergoing surgery. METHODS: This retrospective cohort study included 307 endometrial cancer patients who underwent surgical treatment at Fujian Maternity and Child Health Hospital between January 2022 and December 2024, with follow-up to December 2025. D-dimer change was the exposure variable and VTE occurrence the outcome. Multivariable logistic regression assessed independent effects after adjusting for 17 covariates, including age, body mass index, FIGO stage, and comorbidities. Threshold effect and stratified analyses were conducted. RESULTS: Each one-unit increase in D-dimer change was significantly associated with higher VTE risk (adjusted OR = 1.202; 95% CI: 1.076-1.342; P = 0.001). Nonlinear testing revealed a significant threshold effect (P < 0.001) at 3.78: below this threshold, VTE risk increased sharply (OR = 7.761; 95% CI: 4.286-14.051); above it, risk declined (OR = 0.643; 95% CI: 0.526-0.785). Mediation analysis showed anticoagulant therapy, infection, and caprinin had negligible mediating effects (proportion < 0.2%; P > 0.86). CONCLUSION: D-dimer level changes exhibit a nonlinear association with postoperative VTE risk, characterized by a distinct threshold effect. These hypothesis-generating findings suggest that monitoring D-dimer trajectories rather than absolute values may offer a novel dimension for perioperative VTE risk stratification, warranting prospective validation in multicenter cohorts before clinical application. CI - (c) 2026. The Author(s). FAU - Li, Weipeng AU - Li W AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. FAU - Zheng, Hui AU - Zheng H AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. FAU - Zhen, Lan AU - Zhen L AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. FAU - Qiu, Qian AU - Qiu Q AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. FAU - Zhu, Leilei AU - Zhu L AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. FAU - Zhang, Rong AU - Zhang R AD - Department of Vascular Surgery & Interventional Therapy, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. FAU - Yi, Huan AU - Yi H AUID- ORCID: 0009-0009-9209-916X AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, 350001, China. yi.huan@fjmu.edu.cn. LA - eng GR - No.2025Y9627/the Joint Funds for the Innovation of Science and Technology,Fujian Province/ PT - Journal Article DEP - 20260627 PL - England TA - Thromb J JT - Thrombosis journal JID - 101170542 PMC - PMC13576260 OTO - NOTNLM OT - D-dimer OT - Endometrial cancer OT - Postoperative complications OT - Threshold effect OT - Venous thromboembolism COIS- Declarations. Ethical approval: This study was approved by the Ethics Committee of Fujian Provincial Maternal and Child Health Hospital and strictly adhered to the tenets of the Declaration of Helsinki (IRB: No. 2025KY115). Consent for publication: Not applicable. As this study was a retrospective analysis of de-identified data and the requirement for informed consent was waived by the institutional ethics committee, specific consent for publication was not required. Competing interests: The authors declare no competing interests. EDAT- 2026/06/28 04:09 MHDA- 2026/06/28 04:10 PMCR- 2026/06/27 CRDT- 2026/06/27 23:26 PHST- 2026/02/23 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/06/28 04:10 [medline] PHST- 2026/06/28 04:09 [pubmed] PHST- 2026/06/27 23:26 [entrez] PHST- 2026/06/27 00:00 [pmc-release] AID - 10.1186/s12959-026-00893-2 [pii] AID - 893 [pii] AID - 10.1186/s12959-026-00893-2 [doi] PST - epublish SO - Thromb J. 2026 Jun 27;24(1):84. doi: 10.1186/s12959-026-00893-2. PMID- 42365173 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20261008 IS - 1476-5640 (Electronic) IS - 0954-3007 (Linking) VI - 80 IP - 9 DP - 2026 Sep TI - Evaluation of a context-specific diet diversity score (DDS) for predicting micronutrient adequacy in 6-10-year-old rural Indian children. PG - 919-927 LID - 10.1038/s41430-026-01779-2 [doi] AB - BACKGROUND: Low diet diversity is the major contributor to micronutrient inadequacy among children, underscoring a need for a rapid assessment tool to assess micronutrient adequacy. OBJECTIVE: This study aimed to (i) develop a context-specific diet diversity score (DDS) tool (ii) evaluate the performance of the DDS scoring system against mean probability of adequacy for 10 micronutrients, 5 biomarkers of micronutrient status and (iii) identify an optimal DDS cut-off by applying minimum portion size threshold to support its potential use as a practical screening tool. METHODS: A cross-sectional study was conducted among 6-10-year-old children (n = 76) in two villages of Ghatkesar sub-district, Telangana. Portion sizes of commonly consumed fruits and vegetables were standardized. Data on household demographics, anthropometry, and biomarkers of micronutrient status were collected using a pretested questionnaire and standardized protocols. Three non-consecutive 24-hour-dietary-recalls were obtained using the weighment method. DDS was developed based on the nutrient content of consumed foods; minimum intake thresholds of 0.1 g, 5 g and 10 g was applied while scoring. Mean probability of adequacy (MPA) for 10 micronutrients was estimated using ICMR-EAR values. Correlations of DDS with MPA and biomarkers were examined, and sensitivity and specificity were assessed using ROC curves, considering MPA >/= 70% as adequate. RESULTS: The DDS included 13 food groups. Mean DDS (5 g threshold) was 8.67 +/- 1.50 and correlated significantly with MPA (r = 0.58), and hemoglobin (t = 2.07). A DDS-5 g cut-off of >/=10 predicted MPA > 70%, with an AUC of 0.89. CONCLUSION: The DDS showed good predictive performance for micronutrient adequacy, but requires further field validation before programmatic use. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Konapur, Archana AU - Konapur A AD - Nutrition Information Communication and Health Education (NICHE) Division, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India. FAU - Krishnapillai, Madhavan Nair AU - Krishnapillai MN AD - Independent Researcher; Formerly, Micronutrient Research Group, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India. FAU - Kulkarni, Bharati AU - Kulkarni B AD - Director, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India. FAU - Nagalla, Balakrishna AU - Nagalla B AUID- ORCID: 0000-0002-5613-0942 AD - Department of Statistics, Apollo Hospitals Educational & Research Foundation, Hyderabad, Telangana State, India. FAU - Gavaravarapu, SubbaRao M AU - Gavaravarapu SM AUID- ORCID: 0000-0003-4524-9646 AD - Nutrition Information Communication and Health Education (NICHE) Division, ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India. Subbarao.gm@icmr.gov.in. AD - Faculty of Medical Science, Academy for Scientific and Innovative Research, Ghaziabad, Uttar Pradesh, India. Subbarao.gm@icmr.gov.in. LA - eng GR - 5/9/1138/2014-NUT/Indian Council of Medical Research (ICMR)/ PT - Journal Article DEP - 20260627 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 RN - 0 (Micronutrients) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Micronutrients/administration & dosage/deficiency/blood MH - Child MH - Cross-Sectional Studies MH - India MH - Female MH - *Diet MH - Rural Population MH - *Nutrition Assessment MH - Male MH - Nutritional Status MH - Biomarkers/blood MH - Surveys and Questionnaires MH - Vegetables MH - Fruit MH - ROC Curve MH - Sensitivity and Specificity COIS- Competing interests: The authors declare no competing interests. Ethical approval: The study was approved by the Institutional Ethics Committee (IEC) of ICMR-National Institute of Nutrition, Hyderabad, Telangana State, India (08/I/2014 & CR03/II/2016 (revised)); all methods were performed in accordance with the institutional guidelines and regulations. Written informed consent was obtained from all the participants before initiation of data collection. EDAT- 2026/06/28 00:38 MHDA- 2026/09/10 05:37 CRDT- 2026/06/27 23:19 PHST- 2025/10/23 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/05/25 00:00 [revised] PHST- 2026/09/10 05:37 [medline] PHST- 2026/06/28 00:38 [pubmed] PHST- 2026/06/27 23:19 [entrez] AID - 10.1038/s41430-026-01779-2 [pii] AID - 10.1038/s41430-026-01779-2 [doi] PST - ppublish SO - Eur J Clin Nutr. 2026 Sep;80(9):919-927. doi: 10.1038/s41430-026-01779-2. Epub 2026 Jun 27. PMID- 42365169 OWN - NLM STAT- Publisher LR - 20260627 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Jun 27 TI - Diet, lifestyle, metabolic markers, and socioeconomic status are associated with cognitive function in school-aged children from a population-based cohort. LID - 10.1038/s41390-026-05250-7 [doi] AB - BACKGROUND: Cognitive development is associated with diet, activity, sleep, metabolic health, and socioeconomic status. However, evidence remains limited, as most studies have focused on clinical groups or single factors. We examined the combined associations of these variables with cognitive function in school-aged children from the general population. METHODS: We evaluated 170 school-aged children from a population-based cohort (mean age 6.33 +/- 0.03 years; 49% female). Children were evaluated after an overnight fast (>8 h), and anthropometric, metabolic, and socioeconomic variables were evaluated. Diet and physical activity were assessed using validated questionnaires (Vioque FFQ and enKid). Cognitive function was assessed using NEPSY-II and TONI-2 subsets. Correlation and regression analyses were performed. RESULTS: Cognitive function was positively associated with Mediterranean diet adherence, sleep duration, socioeconomic status, and negatively associated with ultra-processed food intake, TV viewing, and metabolic markers including insulin resistance (HOMA-IR), C-reactive protein, and gamma-glutamyltransferase (all p < 0.05). Multivariate analyses showed that Mediterranean diet adherence (OR 2.18, 95%CI 1.08-4.40), economic status (OR 2.50, 95%CI 1.13-5.49), sleep duration (OR 2.90, 95%CI 1.42-5.92), and HOMA-IR (OR 0.47, 95%CI 0.23-0.96) as independently associated with cognitive outcomes, particularly in attention, language, and memory. CONCLUSIONS: Lifestyle factors and socioeconomic conditions are independently associated with cognitive function in children. IMPACT: Key message: Diet, sleep, metabolic health, and socioeconomic status are associated with cognitive function in school-aged children. Novelty: Simultaneously examines multiple factors associated with cognition in school-aged children from a population-based cohort. Impact on cognition: Mediterranean diet adherence, sleep duration, and metabolic health were positively associated with several cognitive domains, including attention, language, and memory. Practical use: Highlights the potential relevance of healthy lifestyles and social equity in relation to cognitive development. Broader significance: Highlights the multifactorial nature of cognitive development in children. CI - (c) 2026. The Author(s). FAU - Gomez-Vilarrubla, Ariadna AU - Gomez-Vilarrubla A AUID- ORCID: 0000-0001-8183-5218 AD - Maternal-Fetal Metabolic Research Group, Girona Institute for Biomedical Research (IDIBGI), Salt, Spain. FAU - Sanchez-Fernandez, Mario AU - Sanchez-Fernandez M AUID- ORCID: 0009-0009-7616-8559 AD - Department of Pediatrics, Dr. Josep Trueta Hospital, Girona, Spain. FAU - Puerto-Carranza, Elsa AU - Puerto-Carranza E AUID- ORCID: 0000-0003-3478-5072 AD - Department of Pediatrics, Dr. Josep Trueta Hospital, Girona, Spain. FAU - Martinez-Calcerrada, Jose-Maria AU - Martinez-Calcerrada JM AUID- ORCID: 0000-0002-4021-2513 AD - Maternal-Fetal Metabolic Research Group, Girona Institute for Biomedical Research (IDIBGI), Salt, Spain. FAU - Mas-Pares, Berta AU - Mas-Pares B AUID- ORCID: 0000-0001-8283-3089 AD - Pediatric Endocrinology Research Group, Girona Institute for Biomedical Research (IDIBGI), Salt, Spain. FAU - Rivero-Martin, Maria-Jose AU - Rivero-Martin MJ AUID- ORCID: 0000-0003-2186-0475 AD - Department of Pediatrics, Hospital Universitario de Fuenlabrada, Madrid, Spain. FAU - Nso-Roca, Ana-Pilar AU - Nso-Roca AP AUID- ORCID: 0000-0002-0601-0213 AD - Department of Pediatrics, Hospital Universitario San Juan de Alicante, San Juan de Alicante, Spain. FAU - Alvarez-Monell, Adam AU - Alvarez-Monell A AUID- ORCID: 0000-0003-4806-3361 AD - Department of Psychiatry and Forensic Medicine, Neuroscience Institute, Universitat Autonoma de Barcelona (INc-UAB), Barcelona, Spain. FAU - Contreras-Rodriguez, Oren AU - Contreras-Rodriguez O AUID- ORCID: 0000-0001-8922-8084 AD - Department of Psychiatry and Forensic Medicine, Neuroscience Institute, Universitat Autonoma de Barcelona (INc-UAB), Barcelona, Spain. AD - CIBER Mental Health (CIBERSAM), Carlos III Health Institute, Madrid, Spain. FAU - Garre-Olmo, Josep AU - Garre-Olmo J AUID- ORCID: 0000-0002-7817-0814 AD - Department of Medical Sciences, University of Girona, Girona, Spain. FAU - Lopez-Bermejo, Abel AU - Lopez-Bermejo A AUID- ORCID: 0000-0002-5828-8911 AD - Department of Pediatrics, Dr. Josep Trueta Hospital, Girona, Spain. alopezbermejo@idibgi.org. AD - Pediatric Endocrinology Research Group, Girona Institute for Biomedical Research (IDIBGI), Salt, Spain. alopezbermejo@idibgi.org. AD - Department of Medical Sciences, University of Girona, Girona, Spain. alopezbermejo@idibgi.org. FAU - Bassols, Judit AU - Bassols J AUID- ORCID: 0000-0001-8821-6655 AD - Maternal-Fetal Metabolic Research Group, Girona Institute for Biomedical Research (IDIBGI), Salt, Spain. jbassols@idibgi.org. LA - eng PT - Journal Article DEP - 20260627 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Patient consent: Written informed consent was obtained from the parents or legal guardians of all participating children prior to enrolment in the study. EDAT- 2026/06/28 00:37 MHDA- 2026/06/28 00:37 CRDT- 2026/06/27 23:19 PHST- 2025/10/28 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/05/28 00:00 [revised] PHST- 2026/06/28 00:37 [medline] PHST- 2026/06/28 00:37 [pubmed] PHST- 2026/06/27 23:19 [entrez] AID - 10.1038/s41390-026-05250-7 [pii] AID - 10.1038/s41390-026-05250-7 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Jun 27. doi: 10.1038/s41390-026-05250-7. PMID- 42365081 OWN - NLM STAT- Publisher LR - 20260627 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jun 27 TI - Predicting children's undernutrition and its association with women's asset ownership in Ethiopia: spatial machine learning. LID - 10.1038/s41598-026-59905-w [doi] AB - Child undernutrition remains a critical public health concern, with prominent geographic and structural disparities in Ethiopia. Understanding how women's asset share and spatial context interact to affect nutritional risk is vital for effective interventions. This study investigates the spatial patterns of child undernutrition, its association with women's asset ownership and other covariates, and the predictive performance of spatial machine learning techniques in making predictions. Using the nationally representative ESPS 2021/22 for model development and internal validation through spatial cross-validation with a 70/30 split, alongside temporal validation employing ESPS I, 2018/19. The metrics were used to compare four machine learning algorithms (random forest, gradient-boosted trees, support vector machines, and geographical random forests) with spatial features to a spatial generalized linear mixed model. The semivariogram result showed a strong spatial dependence, which supported the use of spatial modeling. The women's asset ownership index, children's age, distance to nearest market, mothers' age, distance to nearest road, household size, child sex, region, toilet type, mother's religion, source of drinking water, and place of residence were significant factors. The results demonstrate a distinct inverse spatial correlation between women's asset ownership and child undernutrition, suggesting that women's economic empowerment functions as a protective structural part. The result of temporal validation showed a growing impact of geographic and contextual factors. Gradient-boosted trees and random forests with spatial features make it easy to model intricate nutritional outcomes in different settings. The results underline geographically targeted child nutrition programs and policies that bolster women's economic autonomy and resilience. Integrating spatial analytics and Gradient-boosted trees and random forests machine learning techniques with gender‑sensitive socioeconomic factors can strengthen precise public health strategies to reduce child undernutrition. CI - (c) 2026. The Author(s). FAU - Dessie, Dereje Bekele AU - Dessie DB AD - Department of Statistics, College of Natural and Computational Science, Madda Walabu University, Bale Robe, Ethiopia. derejebekele@hu.edu.et. AD - Department of Statistics, College of Natural and Computational Science, Hawassa University, Hawassa, Ethiopia. derejebekele@hu.edu.et. FAU - Kitawa, Yonas Shuke AU - Kitawa YS AD - Department of Statistics, College of Natural and Computational Science, Hawassa University, Hawassa, Ethiopia. FAU - Asfaw, Zeytu Gashaw AU - Asfaw ZG AD - Department of Epidemiology and Biostatistics, School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia. LA - eng PT - Journal Article DEP - 20260627 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM OTO - NOTNLM OT - Assets OT - Children OT - Machine learning OT - Undernutrition OT - Women COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: The data were obtained via online registration and downloaded after the purpose of the analysis was communicated and approved. An approval for the use of the ESPS data set was gained from the World Bank Microdata Catalog: https://microdata.worldbank.org/collections/lsms. Ethics approval and participants' consent were not required, as this is publicly available data. EDAT- 2026/06/28 00:36 MHDA- 2026/06/28 00:36 CRDT- 2026/06/27 23:17 PHST- 2026/03/20 00:00 [received] PHST- 2026/06/24 00:00 [accepted] PHST- 2026/06/28 00:36 [medline] PHST- 2026/06/28 00:36 [pubmed] PHST- 2026/06/27 23:17 [entrez] AID - 10.1038/s41598-026-59905-w [pii] AID - 10.1038/s41598-026-59905-w [doi] PST - aheadofprint SO - Sci Rep. 2026 Jun 27. doi: 10.1038/s41598-026-59905-w. PMID- 42364891 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260908 IS - 1873-3492 (Electronic) IS - 0009-8981 (Linking) VI - 592 DP - 2027 Jan 1 TI - Kisspeptin-10/basal LH ratio improves differentiation of central precocious puberty and premature thelarche. PG - 121207 LID - S0009-8981(26)00389-X [pii] LID - 10.1016/j.cca.2026.121207 [doi] AB - BACKGROUND: Distinguishing idiopathic central precocious puberty (ICPP) from premature thelarche (PT) remains a clinical challenge and often necessitates GnRH stimulation testing. Kisspeptin-10 (Kp-10), Neurokinin B (NKB), and Neuropeptide Y (NPY) are key regulators of GnRH secretion and may serve as surrogate biomarkers. We evaluated whether these neuropeptides, alone or in combination with basal gonadotropins, could provide clinically useful discrimination of ICPP and PT. METHODS: In this prospective study, Indian girls aged 6-9 years were enrolled as controls (n = 40), ICPP (n = 33), and PT (n = 23). Anthropometry, basal LH, FSH, estradiol, pelvic ultrasonography, and plasma Kp-10, NKB, and NPY levels were assessed. Diagnostic performance was evaluated using receiver operating characteristic (ROC) analysis. Logistic regression models assessed incremental predictive value: Model 1 included the Kp-10/basal LH ratio; Model 2 added bone age advancement (BA-CA); and Model 3 further included basal estradiol. Clinical utility was examined using decision curve analysis (DCA). RESULTS: Anthropometric parameters did not differ between ICPP and PT. Kp-10 and NKB levels were higher in both early-puberty groups than controls, but neither marker alone discriminated ICPP from PT. The composite Kp-10/basal LH ratio showed superior performance, with an ROC-derived cut-off <4.07 ng/mIU (sensitivity 72.7%, specificity 87.0%, accuracy 78%). All three models showed similar discrimination (AUC 0.78-0.79), with no meaningful improvement after adding BA-CA or estradiol. DCA demonstrated a higher net benefit for the Kp-10/basal LH ratio compared with treat-all or treat-none strategies across clinically relevant thresholds. CONCLUSION: The Kp-10/basal LH ratio provides robust discrimination and meaningful clinical utility in differentiating ICPP from PT and may reduce reliance on GnRH stimulation testing. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Banerjee, Antara A AU - Banerjee AA AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Bhanarkar, Shital R AU - Bhanarkar SR AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Kashikar, Swati AU - Kashikar S AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Keshwani, Rachna AU - Keshwani R AD - Bai Jerbai Wadia Hospital for Children, Acharya Donde Marg, Parel, Mumbai 400 012, India. FAU - Walia, Shagun AU - Walia S AD - Bai Jerbai Wadia Hospital for Children, Acharya Donde Marg, Parel, Mumbai 400 012, India. FAU - Kavya, D R AU - Kavya DR AD - Bai Jerbai Wadia Hospital for Children, Acharya Donde Marg, Parel, Mumbai 400 012, India. FAU - Bombe, Shweta AU - Bombe S AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Pande, Shailesh AU - Pande S AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Modi, Deepak N AU - Modi DN AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Pathak, Bhakti R AU - Pathak BR AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Joshi, Beena AU - Joshi B AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Tandon, Deepti AU - Tandon D AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Patil, Anushree AU - Patil A AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Begum, Shahina AU - Begum S AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Mahale, Smita D AU - Mahale SD AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. FAU - Rao, Sudha AU - Rao S AD - Bai Jerbai Wadia Hospital for Children, Acharya Donde Marg, Parel, Mumbai 400 012, India. Electronic address: c_sudha@hotmail.com. FAU - Surve, Suchitra V AU - Surve SV AD - ICMR-National Institute for Research in Reproductive and Child Health, Jehangir Merwanji Street, Parel, Mumbai 400 012, India. Electronic address: surves@nirrch.res.in. LA - eng PT - Journal Article DEP - 20260627 PL - Netherlands TA - Clin Chim Acta JT - Clinica chimica acta; international journal of clinical chemistry JID - 1302422 RN - 0 (Kisspeptins) RN - 9002-67-9 (Luteinizing Hormone) RN - 0 (KISS1 protein, human) SB - IM MH - Humans MH - *Puberty, Precocious/blood/diagnosis MH - *Kisspeptins/blood MH - Female MH - *Luteinizing Hormone/blood MH - Child MH - Prospective Studies OTO - NOTNLM OT - Idiopathic central precocious puberty OT - Kisspeptin OT - Luteinizing hormone OT - Neurokinin B OT - Premature thelarche COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/28 00:36 MHDA- 2026/09/08 23:35 CRDT- 2026/06/27 19:31 PHST- 2026/03/04 00:00 [received] PHST- 2026/06/19 00:00 [revised] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/09/08 23:35 [medline] PHST- 2026/06/28 00:36 [pubmed] PHST- 2026/06/27 19:31 [entrez] AID - S0009-8981(26)00389-X [pii] AID - 10.1016/j.cca.2026.121207 [doi] PST - ppublish SO - Clin Chim Acta. 2027 Jan 1;592:121207. doi: 10.1016/j.cca.2026.121207. Epub 2026 Jun 27. PMID- 42364851 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260807 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 226 DP - 2026 Nov 1 TI - Hedonic and practicality beliefs form a behaviour-proximal core associated with red and processed meat intake: An attitude network analysis. PG - 108694 LID - S0195-6663(26)00256-4 [pii] LID - 10.1016/j.appet.2026.108694 [doi] AB - Red and processed meat (RPM) consumption remains widespread in high-income populations despite consistent health and sustainability recommendations to reduce intake. Although attitudinal measures reliably predict meat-related intentions and intake, prior work has relied predominantly on aggregate affective and cognitive composites, which conceal how the evaluative system is organised: which evaluations are most structurally embedded, which bridge distinct clusters of meaning, and which sit closest to behaviour. We addressed this by applying an item-level Causal Attitude Network approach in a preregistered cross-sectional survey of 1554 UK adults. A regularised partial-correlation network (EBICglasso) was estimated on 21 evaluative items and a past-week RPM intake sum score; we examined community structure, node centrality, between-community connectivity, and the intake node's neighbourhood, complemented by hierarchical regressions on affective and cognitive composites. Walktrap community detection identified four communities (Hedonics, Morality, Benefits/Vitality, Practicality/Feasibility), with the intake node located within Practicality/Feasibility alongside planning, health, and sustainability-related content. The most central evaluative reactions reflected sensory reward and moral evaluation (e.g., pleasantness, tastiness, moral acceptability). Intake showed its strongest conditional association with planning, with smaller links to strength, pleasantness, sustainability, comfort, and pleasure. Between-community connectivity was concentrated in a few pathways, most notably Hedonics-Practicality/Feasibility and Practicality/Feasibility-Benefits/Vitality. Sex-stratified networks were highly similar despite higher intake among men. In regressions, the composites raised explained variance in intake from R(2) = .05 (demographics) to R(2) = .39, with a stronger association for the affective (beta = .45) than the cognitive composite (beta = .18). The architecture suggests, as hypothesis-generating rather than causal claims, that information-focused appeals about long-term consequences may have limited leverage and that intervention targets more plausibly lie in planning, feasibility, hedonic reliance, and benefit/vitality reframing. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Kraft, Pal AU - Kraft P AD - Department of Psychology, University of Oslo, P. O. Box 1094, Blindern, 0317, Oslo, Norway; Department of Psychology, Oslo New University College, Ullevalsveien 76, 0454, Oslo, Norway. Electronic address: pal.kraft@psykologi.uio.no. FAU - Kraft, Brage AU - Kraft B AD - Department of Behavioral Sciences, Oslo Metropolitan University, P. O. Box 4, St. Olavs plass, 0130, Oslo, Norway. Electronic address: brage.kraft@oslomet.no. LA - eng PT - Journal Article DEP - 20260627 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Cross-Sectional Studies MH - Middle Aged MH - United Kingdom MH - *Red Meat MH - *Feeding Behavior/psychology MH - Young Adult MH - *Food Preferences/psychology MH - *Meat Products MH - *Diet/psychology MH - Adolescent MH - Aged OTO - NOTNLM OT - Causal attitude network OT - Meat attitudes OT - Network analysis OT - Red meat OT - Sex differences COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/28 00:37 MHDA- 2026/08/08 00:37 CRDT- 2026/06/27 19:30 PHST- 2026/04/07 00:00 [received] PHST- 2026/06/23 00:00 [revised] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/08/08 00:37 [medline] PHST- 2026/06/28 00:37 [pubmed] PHST- 2026/06/27 19:30 [entrez] AID - S0195-6663(26)00256-4 [pii] AID - 10.1016/j.appet.2026.108694 [doi] PST - ppublish SO - Appetite. 2026 Nov 1;226:108694. doi: 10.1016/j.appet.2026.108694. Epub 2026 Jun 27. PMID- 42364529 OWN - NLM STAT- MEDLINE DCOM- 20260822 LR - 20260919 IS - 1879-2219 (Electronic) IS - 0966-6362 (Linking) VI - 130 DP - 2026 Oct TI - Reliability and minimal detectable change of knee mechanics during gait and squatting, using markerless motion capture in the workplace. PG - 110266 LID - S0966-6362(26)00176-1 [pii] LID - 10.1016/j.gaitpost.2026.110266 [doi] AB - INTRODUCTION: Meaningful changes in joint mechanics within or across sessions require observed differences greater than measurement error. While markerless motion capture systems have achieved comparable gait parameters to marker-based methods, there is a knowledge gap for markerless approaches applied to postures adopted in the workplace in terms of reliability and minimal detectable change (MDC). OBJECTIVE: To compare within-session reliability, intersession reliability, and MDCs of peak knee angles and moments between walking and squatting in the workplace. METHODS: Three-dimensional markerless motion capture and force plates recorded gait and squat trials for twenty-one female early childhood educators [age: 41.6 yrs (10.7), BMI: 29.3 kg/m(2) (7.7); mean (SD)] before, and immediately following, their work shift. Intraclass correlation coefficients (ICC(2,2)) for reliabilities and MDCs were calculated from two trials or averages each session for peak knee flexion and peak knee adduction angles and moments. RESULTS: Within-session reliability was poor to excellent for gait (ICC(2,2)=0.24-0.94) and moderate to excellent for squats (ICC(2,2)=0.52-0.99). Intersession reliability was moderate to excellent for gait (ICC(2,2)=0.59-0.96) and poor to excellent for squats (ICC(2,2)=0.05-0.96). MDCs for peak knee joint angles and moments ranged from 1.6 to 9.9 degrees and 0.09-0.84 Nm/kg for gait, and 3.7 to 10.2 degrees and 0.05-0.24 Nm/kg for squats, respectively. DISCUSSION/CONCLUSION: Within-session and intersession reliability for peak knee outcomes was higher for squatting compared to gait, and peak knee moments had reduced within-session reliability compared to the peak knee angles. Squat peak knee flexion and adduction angles exceeded the 5 degrees MDC threshold, suggesting that larger differences are required to be interpreted as meaningful. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Hallman, Sarah M J AU - Hallman SMJ AD - Department of Kinesiology and Health Sciences, 200 University Avenue West, University of Waterloo, Waterloo, ON N2L 3G1, Canada. Electronic address: sarah.hallman@uwaterloo.ca. FAU - Peckett, Kimberly H AU - Peckett KH AD - Department of Kinesiology and Health Sciences, 200 University Avenue West, University of Waterloo, Waterloo, ON N2L 3G1, Canada. Electronic address: khpeckett@uwaterloo.ca. FAU - Acker, Stacey M AU - Acker SM AD - Department of Kinesiology and Health Sciences, 200 University Avenue West, University of Waterloo, Waterloo, ON N2L 3G1, Canada; Rehabilitation Sciences, McMaster University, Canada; Mechanical Engineering, Queen's University, Canada. Electronic address: stacey.acker@uwaterloo.ca. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260622 PL - England TA - Gait Posture JT - Gait & posture JID - 9416830 SB - IM MH - Humans MH - Female MH - Motion Capture MH - Reproducibility of Results MH - Biomechanical Phenomena MH - *Knee Joint/physiology MH - Adult MH - *Gait/physiology MH - Range of Motion, Articular/physiology MH - Workplace MH - *Posture/physiology OTO - NOTNLM OT - Early Childhood Educators OT - Knee OT - Markerless Motion Capture OT - Minimal Detectable Change OT - Reliability COIS- Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Stacey Acker reports financial support was provided by Natural Sciences and Engineering Research Council of Canada. Stacey Acker reports financial support was provided by Canadian Foundation for Innovation. Sarah Hallman reports financial support was provided by NSERC. Sarah Hallman reports financial support was provided by Ontario Ministry of Colleges and Universities. Kimberly Peckett reports financial support was provided by Natural Sciences and Engineering Research Council of Canada. Kimberly Peckett reports financial support was provided by Ontario Ministry of Colleges and Universities. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/28 00:36 MHDA- 2026/08/22 23:43 CRDT- 2026/06/27 18:08 PHST- 2026/02/06 00:00 [received] PHST- 2026/06/18 00:00 [revised] PHST- 2026/06/21 00:00 [accepted] PHST- 2026/08/22 23:43 [medline] PHST- 2026/06/28 00:36 [pubmed] PHST- 2026/06/27 18:08 [entrez] AID - S0966-6362(26)00176-1 [pii] AID - 10.1016/j.gaitpost.2026.110266 [doi] PST - ppublish SO - Gait Posture. 2026 Oct;130:110266. doi: 10.1016/j.gaitpost.2026.110266. Epub 2026 Jun 22. PMID- 42364424 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260901 IS - 1095-6859 (Electronic) IS - 0090-8258 (Linking) VI - 211 DP - 2026 Aug TI - PRO-PLATINUM: A randomized, double-blind, placebo controlled study to investigate the efficacy of a probiotic intervention on the gut and vaginal microbiome of ovarian cancer patients undergoing treatment with platinum chemotherapy. PG - 74-78 LID - S0090-8258(26)02036-6 [pii] LID - 10.1016/j.ygyno.2026.06.016 [doi] AB - BACKGROUND: PRO-PLATINUM evaluates whether a 5-strain probiotic formulation can favorably modulate the gut microbiome during platinum-based chemotherapy in ovarian cancer (OC), while assessing feasibility, safety, and translational correlates of response and toxicity. PATIENTS AND METHODS: PRO-PLATINUM is an IRB-approved, randomized, double-blind, placebo-controlled trial enrolling 124 patients with stage II-IV or platinum-sensitive recurrent high-grade OC receiving platinum-based chemotherapy. The study opened to enrollment in February 2026. Participants are randomized 1:1 to a 5-strain probiotic (WBF-038) or placebo, stratified by newly diagnosed advanced versus recurrent disease. The intervention contains inulin and five microbial strains: Akkermansia muciniphila, Anaerobutyricum hallii, Clostridium beijerinckii, Clostridium butyricum, and Bifidobacterium infantis, and is administered orally twice daily beginning within seven days of cycle 1 and continuing through seven days after the completion of cycle 6. Eligible patients must have ECOG performance status 0-2, adequate organ function, and no major probiotic-related contraindications. Stool, blood, and vaginal samples are collected at baseline, cycle 3, and cycle 6; tumor tissue is collected at surgery when available. The primary endpoint is change in gut microbiome composition by whole-genome metagenomic sequencing. Secondary endpoints include intervention adherence, biospecimen feasibility, recurrence-free survival, and overall survival. Exploratory endpoints include toxicity, postoperative infections, stool consistency, diet, medication and antibiotic exposure, quality of life, symptom burden, serum metabolomic and immune profiling, vaginal and tumor microbiome composition, and associations between microbial features and clinical outcomes. CONCLUSIONS: PRO-PLATINUM will evaluate treatment feasibility and safety and generate prospective translational data to inform future microbiome-directed strategies to improve treatment tolerance, quality of life, and outcomes in OC patients. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Chambers, Laura M AU - Chambers LM AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. Electronic address: laura.chambers@osumc.edu. FAU - Spakowicz, Daniel AU - Spakowicz D AD - Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Chalif, Julia AU - Chalif J AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - O'Connor, Reed AU - O'Connor R AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Kistenfeger, Quinn AU - Kistenfeger Q AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Mehra, Yogita AU - Mehra Y AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA; Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Mohssen, Mohamed AU - Mohssen M AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA; Division of Medical Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Abdeen, Cassidy AU - Abdeen C AD - The Ohio State University School of Medicine, USA. FAU - Haight, Paulina AU - Haight P AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Nagel, Christa AU - Nagel C AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Neff, Robert AU - Neff R AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Cohn, David AU - Cohn D AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Copeland, Larry J AU - Copeland LJ AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Backes, Floor AU - Backes F AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Cosgrove, Casey AU - Cosgrove C AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Hays, John AU - Hays J AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. FAU - Dravillas, Caroline AU - Dravillas C AD - The Ohio State University Comprehensive Cancer Center, Columbus, OH, USA. FAU - McLaughlin, Eric AU - McLaughlin E AD - The Ohio State University School of Medicine, Department of Biostatistics, USA. FAU - O'Malley, David AU - O'Malley D AD - Division of Gynecologic Oncology, The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus, OH, USA. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260627 PL - United States TA - Gynecol Oncol JT - Gynecologic oncology JID - 0365304 RN - Q20Q21Q62J (Cisplatin) SB - IM MH - Humans MH - Female MH - Double-Blind Method MH - *Probiotics/administration & dosage/therapeutic use MH - *Ovarian Neoplasms/drug therapy/microbiology/pathology MH - *Gastrointestinal Microbiome/drug effects MH - *Vagina/microbiology MH - Middle Aged MH - Adult MH - *Antineoplastic Combined Chemotherapy Protocols/therapeutic use MH - *Microbiota/drug effects MH - Aged MH - Cisplatin/administration & dosage COIS- Declaration of competing interest The authors have no relevant conflicts of interest. EDAT- 2026/06/28 04:09 MHDA- 2026/08/08 00:37 CRDT- 2026/06/27 18:06 PHST- 2026/06/12 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/08/08 00:37 [medline] PHST- 2026/06/28 04:09 [pubmed] PHST- 2026/06/27 18:06 [entrez] AID - S0090-8258(26)02036-6 [pii] AID - 10.1016/j.ygyno.2026.06.016 [doi] PST - ppublish SO - Gynecol Oncol. 2026 Aug;211:74-78. doi: 10.1016/j.ygyno.2026.06.016. Epub 2026 Jun 27. PMID- 42364371 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260911 IS - 1476-5616 (Electronic) IS - 0033-3506 (Linking) VI - 258 DP - 2026 Sep TI - Age-dependent performance of obesity measures in screening for cardiometabolic risk over the lifespan. PG - 106399 LID - S0033-3506(26)00268-4 [pii] LID - 10.1016/j.puhe.2026.106399 [doi] AB - OBJECTIVES: To evaluate age-specific associations of body mass index (BMI) and waist-to-height ratio (WHtR) with cardiometabolic risk and to explore potential age- and sex-specific screening thresholds. STUDY DESIGN: This cross-sectional study included 58,712 participants from the NHANES in the United States from 1999 to 2020. METHODS: Using data from 58,712 participants (aged 12-85 years) from NHANES 1999-2020, we analyzed age-stratified associations between obesity metrics (BMI, WHtR) and cardiometabolic risk (hypertension, dyslipidemia, diabetes). We used subsample population weights to produce estimates representative of the U.S. POPULATION: Covariates included demographics, lifestyle, socioeconomic factors, and medication use. Logistic regression, receiver operating characteristic (ROC) curves, and population attributable fraction were used. Exploratory age- and sex-specific screening thresholds were estimated using Youden's index. RESULTS: ROC analysis suggested that the discriminative performance of both BMI and WHtR for identifying prevalent cardiometabolic risk decreased with increasing age. The association between adiposity measures and prevalent cardiometabolic risk appeared to attenuate with age, as reflected by lower odds ratios and population attributable fractions. Nonlinear, J-shaped cross-sectional associations of BMI and WHtR with cardiometabolic risk were observed, particularly among older adults, in whom the risk appeared to plateau at higher adiposity levels. The screening performance of conventional obesity thresholds varied across age groups. The exploratory age- and sex-specific thresholds based on the maximum Youden index showed relatively balanced sensitivity and specificity, but require prospective validation. CONCLUSIONS: BMI and WHtR exhibited nonlinear associations with cardiometabolic risk. The strength of these associations and their discriminative performance appeared to decrease with age, suggesting that age- and sex-specific screening thresholds may warrant further investigation. CI - Copyright (c) 2026 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved. FAU - Xue, Yongxi AU - Xue Y AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Qi, Qianjin AU - Qi Q AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Gao, Chaonan AU - Gao C AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Meng, Xin AU - Meng X AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Liu, Wei AU - Liu W AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Yan, Yinkun AU - Yan Y AD - Center for Non-communicable Disease Management, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. Electronic address: ykyan2011@163.com. LA - eng PT - Journal Article DEP - 20260627 PL - Netherlands TA - Public Health JT - Public health JID - 0376507 SB - IM MH - Humans MH - Male MH - Female MH - Middle Aged MH - Cross-Sectional Studies MH - Aged MH - *Obesity/epidemiology/diagnosis MH - Adult MH - Adolescent MH - Body Mass Index MH - Aged, 80 and over MH - United States/epidemiology MH - Young Adult MH - *Cardiometabolic Risk Factors MH - Waist-Height Ratio MH - Nutrition Surveys MH - Child MH - Age Factors MH - *Cardiovascular Diseases/epidemiology MH - *Mass Screening OTO - NOTNLM OT - BMI OT - Cardiometabolic risk OT - Life-course epidemiology OT - Obesity OT - Waist-to-height ratio COIS- Declaration of competing interests The authors declared no conflict of interest. EDAT- 2026/06/28 04:09 MHDA- 2026/09/11 23:36 CRDT- 2026/06/27 18:04 PHST- 2025/11/02 00:00 [received] PHST- 2026/05/15 00:00 [revised] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/09/11 23:36 [medline] PHST- 2026/06/28 04:09 [pubmed] PHST- 2026/06/27 18:04 [entrez] AID - S0033-3506(26)00268-4 [pii] AID - 10.1016/j.puhe.2026.106399 [doi] PST - ppublish SO - Public Health. 2026 Sep;258:106399. doi: 10.1016/j.puhe.2026.106399. Epub 2026 Jun 27. PMID- 42363975 OWN - NLM STAT- Publisher LR - 20260702 IS - 1432-0932 (Electronic) IS - 0940-6719 (Linking) DP - 2026 Jun 27 TI - Comment on "Responsiveness and minimal clinically important changes of surface topography parameters in adolescents with idiopathic scoliosis: results from the schroth exercise trial". LID - 10.1007/s00586-026-10140-x [doi] AB - OBJECTIVE: To offer constructive comments on the recent study by Mohamed et al. published in European Spine Journal, with a focus on the clinical detectability of the proposed minimal clinically important changes (MCICs) for surface topography (ST) parameters, the robustness of the anchoring method, and the differential responsiveness between thoracic and lumbar curve subgroups, aiming to provide reference for future research on ST application in conservative management of adolescent idiopathic scoliosis (AIS). METHODS: This commentary was developed through logical analysis of the original study data and cross-referencing with existing literature, addressing three key aspects: (1) a theoretical comparison between the reported MCIC values and the inherent measurement error (minimal detectable change, MDC) of ST systems to evaluate their clinical discriminability; (2) an examination of the limitations of using the Global Rating of Change (GRC) scale as a single anchoring tool, with suggestions for incorporating the SRS-22 self-image domain and region-specific parameters as complementary measures; and (3) an interpretation of the discordance between ST parameter changes and patient perception in the thoracic subgroup, supported by independent evidence from postoperative AIS studies on the correlation between radiographic parameters and self-image RESULTS: The MCIC values proposed in the original study-0.27 mm for RMS and 0.49 mm for MaxDev-are substantially smaller than the known measurement errors of most ST systems. Without reporting the MDC, such "clinically important" changes may be indistinguishable from random noise. The correlation between GRC scores and ST parameter changes was only moderate (r approximately -0.5), and the use of a single global parameter failed to capture shoulder and waist asymmetries, limiting its ability to reflect clinically meaningful improvement in thoracic curves. Independent postoperative evidence supports the authors' hypothesis that lumbar curve changes are more readily perceived by patients, as residual thoracolumbar/lumbar curve magnitude, but not the main thoracic curve, correlates with SRS-22 self-image scores. CONCLUSION: The original study provides pioneering data on ST parameters in AIS; however, the clinical application of its MCIC values warrants cautious interpretation. Future studies should systematically report MDC to establish measurement reliability, employ multi-dimensional anchoring tools (e.g., SRS-22), and develop region-specific or composite ST parameters, particularly optimized for patients with thoracic curves, to more accurately capture patient-perceived clinical improvement. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Zhu, Hai AU - Zhu H AD - Graduate School of Gansu University of Traditional Chinese Medicine, Gansu, China. FAU - Wang, Zhengping AU - Wang Z AD - Graduate School of Gansu University of Traditional Chinese Medicine, Gansu, China. FAU - Feng, Yiwen AU - Feng Y AD - Graduate School of Gansu University of Traditional Chinese Medicine, Gansu, China. FAU - Liu, Yongming AU - Liu Y AD - Department of Spinal and Orthopedic Surgery IV, Gansu Provincial Hospital of Traditional Chinese Medicine, Gansu, China. Lymgszyydx123@163.com. LA - eng PT - Journal Article PT - Review DEP - 20260627 PL - Germany TA - Eur Spine J JT - European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society JID - 9301980 SB - IM OTO - NOTNLM OT - Adolescent idiopathic scoliosis OT - Clinical outcome assessment OT - Minimal clinically important change OT - Minimal detectable change OT - Schroth exercises OT - Surface topography COIS- Declarations. Conflict of interests: The authors declare no competing interests. EDAT- 2026/06/27 12:38 MHDA- 2026/06/27 12:38 CRDT- 2026/06/27 11:04 PHST- 2026/06/16 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/06/16 00:00 [revised] PHST- 2026/06/27 12:38 [pubmed] PHST- 2026/06/27 12:38 [medline] PHST- 2026/06/27 11:04 [entrez] AID - 10.1007/s00586-026-10140-x [pii] AID - 10.1007/s00586-026-10140-x [doi] PST - aheadofprint SO - Eur Spine J. 2026 Jun 27. doi: 10.1007/s00586-026-10140-x. PMID- 42363556 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260916 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 26 DP - 2026 Jun 26 TI - Association between body fat indices and female infertility: A cross-sectional study. PG - e49327 LID - 10.1097/MD.0000000000049327 [doi] LID - e49327 AB - Excess body fat and its distribution are known to influence female reproductive function; however, the relationship between emerging body fat-related indices and infertility remains insufficiently explored. This study aimed to investigate the association between the Conicity Index (C-index), Relative Fat Mass (RFM), and Metabolic Score for Visceral Fat (METS-VF) and infertility among women of reproductive age in the United States. The study included women aged 18 to 45 years and assessed infertility using the National Health and Nutrition Examination Survey question RHQ074 on reproductive health. Multivariable logistic regression, adjusted for confounders, was used to analyze the association between body fat indices and infertility risk. Receiver operating characteristic curve analysis was conducted to evaluate each metric's predictive strength. Of 1103 women, 132 reported infertility. Infertile women had higher C-index (1.3 vs 1.27), RFM (43 vs 40), and METS-VF (8.24 vs 7.37) than fertile women. Each 1-unit increase in these indices was associated with higher odds of infertility (C-index odds ratio [OR] = 2.73, RFM OR = 1.07, METS-VF OR = 1.28). METS-VF had the highest predictive value (area under the curve = 0.65), as confirmed by random forest analysis. Positive associations between infertility and C-index, RFM, and METS-VF suggest that these indices could help assess infertility risk and support targeted reproductive health interventions. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Huang, Li AU - Huang L AD - Academy for Educational Development and Innovation, The Education University of Hong Kong, Hong Kong SAR, People's Republic of China. AD - Puding No. 2 Middle School, Anshun, Guizhou, People's Republic of China. FAU - Yang, Wei Jing AU - Yang WJ AUID- ORCID: 0009-0003-6704-7014 AD - Department of Gynecology, Puding County People's Hospital, Anshun, Guizhou, People's Republic of China. FAU - Kuang, Gui Rong AU - Kuang GR AD - Department of Reproductive Medicine, Anshun People's Hospital, Anshun, Guizhou, People's Republic of China. FAU - Li, Xiang Yan AU - Li XY AD - Department of Gynecology, Puding County People's Hospital, Anshun, Guizhou, People's Republic of China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Female MH - *Infertility, Female/epidemiology/etiology MH - Cross-Sectional Studies MH - Adult MH - Body Mass Index MH - Intra-Abdominal Fat MH - Nutrition Surveys MH - Middle Aged MH - Young Adult MH - United States/epidemiology MH - ROC Curve MH - Adolescent MH - Risk Factors MH - Obesity/complications MH - *Adipose Tissue PMC - PMC13313760 OTO - NOTNLM OT - Conicity Index (C-index) OT - Metabolic Score for Visceral Fat (METS-VF) OT - NHANES OT - Relative Fat Mass Index (RFM) OT - infertility COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2026/06/27 10:10 MHDA- 2026/06/28 10:11 PMCR- 2026/06/26 CRDT- 2026/06/27 01:00 PHST- 2026/02/02 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/06/28 10:11 [medline] PHST- 2026/06/27 10:10 [pubmed] PHST- 2026/06/27 01:00 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 00005792-202606260-00109 [pii] AID - MD-D-26-01949 [pii] AID - 10.1097/MD.0000000000049327 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jun 26;105(26):e49327. doi: 10.1097/MD.0000000000049327. PMID- 42363543 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260916 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 26 DP - 2026 Jun 26 TI - Serum total bilirubin and childhood asthma: Results of the NHANES 2007-2018 and Mendelian randomization study. PG - e49528 LID - 10.1097/MD.0000000000049528 [doi] LID - e49528 AB - Total bilirubin possesses antioxidant and immunomodulatory properties, and its role in childhood asthma is a topic of ongoing debate. We employed both a cross-sectional study and Mendelian randomization (MR) analysis to explore the link between serum total bilirubin and childhood asthma. In the cross-sectional study from the National Health and Nutrition Examination Survey 2007 to 2018, weighted logistic regression models were utilized to investigate the association between serum total bilirubin and childhood asthma. We also used restricted cubic splines to explore the dose-response relationship between the 2. The inverse-variance weighted method was used as the main method of MR analysis to explore the causal effect of exposure on outcomes. A total of 3238 participants were included in the cross-sectional study. Weighted logistic regression analysis encompassing all participants revealed no significant association between total bilirubin levels and the risk of childhood asthma (P > .05). The same results were obtained after categorizing participants into tertiles based on total bilirubin levels. The restricted cubic splines curve revealed an S-shaped relationship between total bilirubin levels and childhood asthma. MR analysis reveals no causal association between serum total bilirubin and childhood asthma (odds ratio [OR] = 0.974, P = .752), peak expiratory flow (OR = 1.002, P = .831), and forced expiratory volume in 1-second (OR = 1.005, P = .554). Our study did not support a causal relationship between serum total bilirubin and childhood asthma. Further studies with a larger number of cases are crucial to validate our findings. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - He, Lijun AU - He L AD - Department of Ultrasound, The Second Affiliated Hospital of Army Medical University, Chongqing, China. FAU - Wang, Kang AU - Wang K AUID- ORCID: 0000-0002-0967-3872 AD - Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Army Medical University, Chongqing, China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - RFM9X3LJ49 (Bilirubin) SB - IM MH - Humans MH - *Bilirubin/blood MH - *Asthma/blood/epidemiology/genetics MH - Female MH - Cross-Sectional Studies MH - Mendelian Randomization Analysis MH - Male MH - Nutrition Surveys MH - Child MH - Logistic Models MH - Risk Factors PMC - PMC13313767 OTO - NOTNLM OT - Mendelian randomization OT - National Health and Nutrition Examination Survey OT - childhood asthma OT - correlation OT - serum total bilirubin COIS- The authors have no funding or conflicts of interest to disclose. EDAT- 2026/06/27 10:10 MHDA- 2026/06/28 16:09 PMCR- 2026/06/26 CRDT- 2026/06/27 01:00 PHST- 2025/07/22 00:00 [received] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/06/28 16:09 [medline] PHST- 2026/06/27 10:10 [pubmed] PHST- 2026/06/27 01:00 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 00005792-202606260-00096 [pii] AID - MD-D-25-09095 [pii] AID - 10.1097/MD.0000000000049528 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jun 26;105(26):e49528. doi: 10.1097/MD.0000000000049528. PMID- 42363402 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 1097-4598 (Electronic) IS - 0148-639X (Print) IS - 0148-639X (Linking) VI - 74 IP - 3 DP - 2026 Sep TI - The Use of the Four Square Step Test and the 10-m Walk/Run Test to Determine Fall Risk in Children With Duchenne Muscular Dystrophy. PG - 740-746 LID - 10.1002/mus.70325 [doi] AB - INTRODUCTION/AIMS: The identification of the risk of falling in Duchenne muscular dystrophy (DMD) is essential for the implementation of timely preventive approaches. This study aimed to examine the ability of the four square step test (FSST) and the 10-m walk/run test (10MWRT) to discriminate between fallers and non-fallers in children with DMD. METHODS: Ninety-five children with DMD were included in this study. Functional level was determined with the Vignos Scale. Children who had fallen at least once in the previous month were categorized as "fallers" (n = 50), while those who had not fallen were categorized as "non-fallers" (n = 45). The FSST and 10MWRT were performed. The Mann-Whitney U test was performed to examine group differences in the FSST and 10MWRT scores. The predictive values of the FSST and 10MWRT were determined with receiver operating characteristic curves. RESULTS: The demographic characteristics of fallers (median age: 9.50 years; median body mass index [BMI]: 19.02 kg/m(2)) and non-fallers (median age: 9.00 years; median BMI: 17.95) were similar (p > 0.05). Fallers demonstrated lower functional levels compared with non-fallers (p < 0.001). The FSST for fallers was 20.04 +/- 12.57 s while that for non-fallers was 11.44 +/- 2.94 s with a cut-off point of 13.10 s (p < 0.05). The 10MWRT for fallers and non-fallers were 9.42 +/- 4.77 and 5.36 +/- 2.10 s, respectively, with a cut-off point of 5.60 s (p < 0.05). DISCUSSION: The two outcome measures were shown to be sensitive and specific in determining the risk of falls in children with DMD. The cut-off points may guide professionals in planning a proactive rehabilitation program to reduce fall risk or minimize subsequent injuries. CI - (c) 2026 The Author(s). Muscle & Nerve published by Wiley Periodicals LLC. FAU - Bulut, Numan AU - Bulut N AUID- ORCID: 0000-0001-5427-1103 AD - Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey. FAU - Aldirmaz, Esra AU - Aldirmaz E AUID- ORCID: 0000-0003-2132-4541 AD - Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey. AD - Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Final International University, Mersin, Turkey. FAU - Alemdaroglu-Gurbuz, Ipek AU - Alemdaroglu-Gurbuz I AUID- ORCID: 0000-0001-5556-6608 AD - Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey. FAU - Tunca, Oznur AU - Tunca O AUID- ORCID: 0000-0002-0855-9541 AD - Faculty of Physical Therapy and Rehabilitation, Hacettepe University, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260626 PL - United States TA - Muscle Nerve JT - Muscle & nerve JID - 7803146 SB - IM MH - Humans MH - *Muscular Dystrophy, Duchenne/physiopathology/diagnosis MH - *Accidental Falls/prevention & control MH - Child MH - Male MH - *Walking/physiology MH - Female MH - *Exercise Test/methods MH - ROC Curve MH - *Walk Test/methods MH - Adolescent PMC - PMC13471885 OTO - NOTNLM OT - fall OT - gait OT - muscular dystrophy OT - physical therapy OT - timed functional test COIS- The authors declare no conflicts of interest. EDAT- 2026/06/27 10:10 MHDA- 2026/08/13 12:42 PMCR- 2026/08/13 CRDT- 2026/06/27 00:04 PHST- 2026/05/21 00:00 [revised] PHST- 2025/06/29 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/08/13 12:42 [medline] PHST- 2026/06/27 10:10 [pubmed] PHST- 2026/06/27 00:04 [entrez] PHST- 2026/08/13 00:00 [pmc-release] AID - MUS70325 [pii] AID - 10.1002/mus.70325 [doi] PST - ppublish SO - Muscle Nerve. 2026 Sep;74(3):740-746. doi: 10.1002/mus.70325. Epub 2026 Jun 26. PMID- 42363297 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260920 LR - 20260923 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 12 IP - 1 DP - 2026 Jun 26 TI - Effects of an infant formula containing a whey protein concentrate on feeding tolerance and markers of intestinal immune defense in Chinese infants. LID - 10.1186/s40795-026-01395-0 [doi] LID - 194 AB - BACKGROUND: Human milk (HM) bioactive components can have immune modulatory functions, impact the gut microbiome, and may result in functional benefits when added to infant formula (IF). In this single-arm, prospective, intervention study, we tested the effectiveness of an IF with a whey protein concentrate co-enriched in alpha-lactalbumin, milk fat globule membrane (MFGM), and Sn-2 palmitate resulting in protein and lipid profiles observed in HM. The outcomes tested were feeding tolerance, Bifidobacteria abundance, and intestinal and immune health of Chinese infants. METHODS: Predominantly formula-fed (FF) and breastfed (BF) infants were enrolled between 3 and 28 days and assigned to the FF (N = 60) or BF (N = 60) group, per their feeding practice, for 6 weeks. The primary endpoint was Infant Gastrointestinal Symptom Questionnaire (IGSQ) index score assessed using a validated IGSQ-13 questionnaire after 6 weeks of intervention; non-inferiority of FF vs BF was tested. Secondary endpoints included fecal Bifidobacteria abundance assessed using shotgun metagenomics sequencing; fecal short chain fatty acids (SCFAs) analyzed by ultra-performance liquid chromatography-tandem mass spectrometry; fecal markers of immune response, inflammation, intestinal barrier integrity (secretory immunoglobulin A sIgA), cytokines, calprotectin, alpha1 antitrypsin, lipocalin-2) assessed using enzyme-linked immunosorbent assay; stool consistency assessed using gastrointestinal (GI) diary; anthropometric assessments; quality of life; physician reported adverse events; and use of medications. RESULTS: Good GI tolerance was observed in both groups at V2 (mean +/- SD IGSQ score FF: 19.9 +/- 7.4; BF: 16.8 +/- 4.2); difference of means 1.35 [95% CI: -1.312, 4.012]). After 6 weeks, Bifidobacterium genus relative abundance was not significantly different between the groups. Total SCFAs were significantly higher (p < 0.05) in the FF versus BF group, driven by increased levels of valeric and propanoic acids (p < 0.05 for both). The IGSQ domain scores, stool consistency, fecal markers of immunity, inflammation, and intestinal barrier integrity (except lipocalin-2 which was significantly higher in BF vs FF), anthropometric Z-scores, common illnesses, antibiotic use, and adverse events were not significantly different between groups at week 6. CONCLUSIONS: Our results support the effectiveness of this tested infant formula in supporting good GI tolerance, growth, specific intestinal and immune health markers, and Bifidobacteria abundance similar to that of the BF group. TRIAL REGISTRATION: NCT04880083 (2021-05-06). CI - (c) 2026. The Author(s). FAU - Wang, Ying AU - Wang Y AD - Division of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Liu, Min AU - Liu M AD - Shanghai Public Health Clinical Centre, Shanghai, China. FAU - Dogra, Shaillay Kumar AU - Dogra SK AD - Nestle Research, Societe Des Produits Nestle SA, 1000, Lausanne 26, Switzerland. FAU - Vidal, Karine AU - Vidal K AD - Nestle Research, Societe Des Produits Nestle SA, 1000, Lausanne 26, Switzerland. FAU - Godin, Jean-Philippe AU - Godin JP AD - Nestle Research, Societe Des Produits Nestle SA, 1000, Lausanne 26, Switzerland. FAU - Darwish, Noura AU - Darwish N AD - Clinical Research Unit, Societe Des Produits Nestle SA, 1000, Lausanne, Switzerland. FAU - Wei, Xiaona AU - Wei X AD - Nestle Research, Societe Des Produits Nestle SA, Singapore, 618802, Singapore. FAU - Reymond, Lucas AU - Reymond L AD - Clinical Research Unit, Societe Des Produits Nestle SA, 1000, Lausanne, Switzerland. FAU - Li, Qiaoji AU - Li Q AD - Nestle R&D (China) Ltd, Beijing, 100016, China. FAU - Dong, Jie AU - Dong J AD - Wyeth Nutrition, Shanghai, 200040, China. FAU - Vyllioti, Aikaterini Themis AU - Vyllioti AT AD - Clinical Research Unit, Societe Des Produits Nestle SA, 1000, Lausanne, Switzerland. FAU - Bettler, Jodi AU - Bettler J AD - Nestle Product Technology Center-Nutrition, Societe Des Produits Nestle SA, 1800, Vevey, Switzerland. FAU - Kennedy, Elaine AU - Kennedy E AD - Nestle Development Centre Nutrition, Wyeth Nutritionals Ireland Ltd., Askeaton, Co. Limerick, Ireland. FAU - Wang, Keqing AU - Wang K AD - BGI-Shenzhen, Shenzhen, 518083, China. FAU - Zhai, Qiangrong AU - Zhai Q AD - BGI-Shenzhen, Shenzhen, 518083, China. FAU - O'Regan, Jonathan AU - O'Regan J AD - Nestle Development Centre Nutrition, Wyeth Nutritionals Ireland Ltd., Askeaton, Co. Limerick, Ireland. FAU - Samuel, Tinu Mary AU - Samuel TM AD - Nestle Product Technology Center-Nutrition, Societe Des Produits Nestle SA, 1800, Vevey, Switzerland. FAU - Cai, Wei AU - Cai W AD - Division of Pediatric Gastroenterology and Nutrition, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. caiw204@sjtu.edu.cn. AD - Shanghai Institute of Pediatric Research, Shanghai, China. caiw204@sjtu.edu.cn. LA - eng SI - ClinicalTrials.gov/NCT04880083 PT - Journal Article DEP - 20260626 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC13591888 OTO - NOTNLM OT - Bifidobacteria OT - Sn-2-palmitate OT - Gastrointestinal tolerance OT - Growth OT - Infant formula OT - Intestinal and immune health OT - MFGM OT - alpha-lactalbumin COIS- Declarations. Ethics approval and consent to participate: This study was approved by the ethics committees at the two institutions in China which were the Ethics Committee of Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (XHEC-C-2020-053-1, and the Ethics Committee of Shanghai Public Health Clinical Center (2020-E151-01, respectively and conducted in compliance with the Declaration of Helsinki and the International Conference on Harmonization Guidelines for Good Clinical Practice. This study was also approved by the Human Genetic Resource Administrative Committee of the Ministry of Science and Technology of China according to the applicable regulation before the study was initiated. Prior to enrollment, parent(s)/legally authorized representative provided written informed consent. This trial was registered on ClinicalTrials.gov (NCT04880083). Competing interests: TMS, SKD, KV, JPG, ND, XW, LR, QL, JD, JB, EK, and JR are employees of Societe des Produits Nestle S.A., the sponsors of this trial. ATV was an employee of Societe des Produits Nestle S.A. at the time the study was conducted. KW, QZ are employees of Beijing Genomics Institute, with whom Nestle had a service agreement. YW, ML and WC received a grant from Nestle to conduct the study. The investigational products were provided by Wyeth Nutritional (China) Co., Limited. Consent for publication: Not applicable as the manuscript does not contain data from any individual person. EDAT- 2026/06/27 04:10 MHDA- 2026/06/27 04:11 PMCR- 2026/06/26 CRDT- 2026/06/26 23:51 PHST- 2024/05/08 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/06/27 04:11 [medline] PHST- 2026/06/27 04:10 [pubmed] PHST- 2026/06/26 23:51 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 10.1186/s40795-026-01395-0 [pii] AID - 1395 [pii] AID - 10.1186/s40795-026-01395-0 [doi] PST - epublish SO - BMC Nutr. 2026 Jun 26;12(1):194. doi: 10.1186/s40795-026-01395-0. PMID- 42362956 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 7 DP - 2026 Jun 27 TI - Feasibility of image-based 3D avatar anthropometry assessment of pediatric obesity: a pilot study. LID - 534 [pii] LID - 10.1007/s00431-026-07187-9 [doi] AB - The purpose of this study is to evaluate the feasibility and validity of 3D avatar-based anthropometry for assessing anthropometric indicators of overweight and obesity in children based on artificial intelligence-derived 3D body reconstruction. This cross-sectional study included 171 children aged 8-10 years from five primary schools in southern Spain. Due to technical constraints of the reconstruction software, 75 children meeting predefined image quality and body weight requirements (>/= 30 kg) were eligible for 3D avatar analysis. Manual anthropometric measurements were obtained following International Society for the Advancement of Kinanthropometry (ISAK) standards and compared with avatar-derived circumferences. Agreement was assessed by using Wilcoxon tests, Spearman correlations, Bland-Altman analyses, and false discovery rate-adjusted comparisons. Avatar-derived circumferences were consistently greater than manual measurements, although waist-to-hip and waist-to-stature ratios demonstrated no significant differences. Avatar and manual circumferences were moderately to strongly correlated (Spearman's rho = 0.62-0.72; adjusted p < 0.05). However, the mean absolute errors ranged from 6.21 to 7.11 cm, and Bland-Altman analysis revealed systematic overestimation with wide limits of agreement, particularly for waist and hip circumferences. Despite these discrepancies, both methods similarly discriminated between weight status categories. CONCLUSION: Image-based 3D avatar anthropometry is a feasible, noninvasive approach for population-level screening and research in pediatric settings. Although the system reliably captures relative differences and body proportions, its current accuracy is insufficient for individual-level clinical assessment. Further algorithmic refinement and validation in lighter and more diverse pediatric populations are needed before clinical implementation. WHAT IS KNOWN: * Childhood obesity remains a major public health challenge requiring accurate monitoring. * Anthropometric assessment still relies mainly on manual measurements, while AI-based 3D body modeling offers a promising non-invasive alternative. WHAT IS NEW: * Image-based 3D avatar anthropometry is feasible in school settings but is constrained by technical requirements. * Avatar measurements are correlated with manual anthropometry and preserve weight status discrimination but demonstrate systematic overestimation and limited agreement. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Del Mar Ucles-Torrente, Maria AU - Del Mar Ucles-Torrente M AUID- ORCID: 0009-0005-3057-9062 AD - Department of Nursing, Pharmacology and Physiotherapy, University of Cordoba, Campus Menendez Pidal, 14071, Cordoba, Spain. AD - GE10 Clinical and Epidemiological Research in Primary Care (GICEAP), Maimonides Institute of Biomedical Research of Cordoba, 14071, Cordoba, Spain. AD - Biomedicine Program, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Cordoba, Spain. FAU - Ruiz-Gamarra, Gema Esperanza AU - Ruiz-Gamarra GE AUID- ORCID: 0009-0000-6124-2896 AD - GE10 Clinical and Epidemiological Research in Primary Care (GICEAP), Maimonides Institute of Biomedical Research of Cordoba, 14071, Cordoba, Spain. AD - Biomedicine Program, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), University of Cordoba, Cordoba, Spain. AD - Clinical Management Unit, Health Center, Dr. Trujillo Street, Palma del Rio, 14700, Cordoba, Spain. FAU - Alcalde-Llergo, Jose Manuel AU - Alcalde-Llergo JM AUID- ORCID: 0000-0002-3607-260X AD - Computer Science, University of Cordoba, Campus de Rabanales, 14071, Cordoba, Andalucia, Spain. FAU - Vaquero-Alvarez, Manuel AU - Vaquero-Alvarez M AUID- ORCID: 0000-0001-9730-6310 AD - GC09 Nutrigenomics, Metabolic Syndrome, Maimonides Institute of Biomedical Research of Cordoba, 14071, Cordoba, Spain. AD - Faculty of Medicine and Nursing, University of Cordoba, 14071, Cordoba, Spain. FAU - Blancas-Sanchez, Isabel Maria AU - Blancas-Sanchez IM AD - GC09 Nutrigenomics, Metabolic Syndrome, Maimonides Institute of Biomedical Research of Cordoba, 14071, Cordoba, Spain. AD - Occidente Azahara Healthcare Center Cordoba, 14011, Cordoba, Spain. FAU - Aparicio-Martinez, Pilar AU - Aparicio-Martinez P AD - Department of Nursing, Pharmacology and Physiotherapy, University of Cordoba, Campus Menendez Pidal, 14071, Cordoba, Spain. n32apmap@uco.es. AD - GE10 Clinical and Epidemiological Research in Primary Care (GICEAP), Maimonides Institute of Biomedical Research of Cordoba, 14071, Cordoba, Spain. n32apmap@uco.es. FAU - Vaquero-Abellan, Manuel AU - Vaquero-Abellan M AUID- ORCID: 0000-0002-0602-317X AD - Department of Nursing, Pharmacology and Physiotherapy, University of Cordoba, Campus Menendez Pidal, 14071, Cordoba, Spain. AD - GE10 Clinical and Epidemiological Research in Primary Care (GICEAP), Maimonides Institute of Biomedical Research of Cordoba, 14071, Cordoba, Spain. LA - eng PT - Journal Article DEP - 20260627 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Child MH - Pilot Projects MH - *Avatar MH - Female MH - Feasibility Studies MH - Male MH - *Anthropometry/methods MH - Cross-Sectional Studies MH - *Imaging, Three-Dimensional/methods MH - *Pediatric Obesity/diagnosis MH - Spain MH - Reproducibility of Results MH - Artificial Intelligence OTO - NOTNLM OT - 3D avatar-based anthropometry OT - Modeling OT - Obesity OT - Pediatric OT - Photometric COIS- Declarations. Ethical Approval: The study was approved by the Bioethics Committee of the Reina Sofia University Hospital of Cordoba (Approval number: 5864). Informed consent: All of the participants and their parents/legal guardians received detailed information about the objectives, risks, and benefits of the study and provided written informed consent. Participation was voluntary, and participants could withdraw at any time without justification. Consent to participate: All of the participants provided consent to participate. Consent to publish: All of the participants gave permission for data use and later publication. Competing interests: The authors declare no competing interest. EDAT- 2026/06/27 00:58 MHDA- 2026/06/28 07:10 CRDT- 2026/06/26 23:26 PHST- 2026/01/22 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/06/11 00:00 [revised] PHST- 2026/06/28 07:10 [medline] PHST- 2026/06/27 00:58 [pubmed] PHST- 2026/06/26 23:26 [entrez] AID - 10.1007/s00431-026-07187-9 [pii] AID - 10.1007/s00431-026-07187-9 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jun 27;185(7):534. doi: 10.1007/s00431-026-07187-9. PMID- 42362911 OWN - NLM STAT- Publisher LR - 20260726 IS - 1559-064X (Electronic) IS - 1559-0631 (Linking) DP - 2026 Jun 26 TI - Diet and mycoestrogen exposure in a pregnancy cohort: the Jersey Babies pilot study. LID - 10.1038/s41370-026-00940-0 [doi] AB - BACKGROUND: Zearalenone (ZEN) is a grain-contaminating mycotoxin and potent estrogen receptor agonist linked to reproductive and perinatal disruption in animal models, with emerging epidemiologic evidence in humans. Despite widespread U.S. exposure, dietary sources remain unclear. OBJECTIVE: This pilot study assessed prenatal mycoestrogen exposure and related dietary sources in a U.S. pregnant cohort. METHODS: Pregnant women (n = 33) recruited in New Brunswick, NJ provided urine samples and completed time-matched 24-h dietary recalls at three points across pregnancy (Visit 1: 18-20 weeks; Visit 2: 24-26 weeks and Visit 3: 28-32 weeks gestation). Urinary mycoestrogens were quantified using LC/MSMS and corrected for specific gravity. RESULTS: At least one ZEN metabolite was detected in every sample (Visit, median: 1: 0.058 ng/mg; 2: 0.042 ng/mg; 3: 0.055 ng/mg), and intraclass correlation coefficients among detected metabolites ranged from 0.62 to 0.95. Across visits, Hispanic participants (39%) had 52-109% higher mycoestrogen concentrations compared to non-Hispanic participants (p < 0.05). Consumption of corn and other grain products within the past 24 h was strongly correlated with urinary concentrations of ZEN and its metabolites (r: 0.30-0.92; p < 0.05), with weaker positive correlations observed for oils and popcorn. SIGNIFICANCE: Given robust toxicologic evidence and emerging epidemiologic findings suggesting adverse maternal and child health impacts, identifying key exposure pathways is critical. IMPACT: This pilot study identifies corn and cereal-based foods as key contributors to ZEN prenatal exposure and highlights higher concentrations among Hispanic participants. By clarifying exposure pathways, these findings support improved food-safety monitoring and targeted strategies to reduce endocrine-disrupting chemical exposures during pregnancy. CI - (c) 2026. The Author(s). FAU - Rivera-Nunez, Zorimar AU - Rivera-Nunez Z AUID- ORCID: 0000-0002-0718-1807 AD - Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA. zorimar.nunez@rutgers.edu. AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. zorimar.nunez@rutgers.edu. FAU - Kinkade, Carolyn W AU - Kinkade CW AUID- ORCID: 0000-0002-8549-5553 AD - Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA. FAU - Juenke, Alyssa AU - Juenke A AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. FAU - Hansel, Megan AU - Hansel M AD - Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA. FAU - Heltberg, Daniel AU - Heltberg D AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. AD - School of Biological Sciences, University of Aberdeen, Aberdeen, Scotland, UK. FAU - Sharada, Aditi AU - Sharada A AD - Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA. FAU - Anthony, Shabree AU - Anthony S AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. FAU - Brinker, Anita AU - Brinker A AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. FAU - Fields, Jessica AU - Fields J AD - Department of Obstetrics and Gynecology, Rutgers Robert Wood Johnson University Hospital, New Brunswick, NJ, USA. FAU - Rosen, Todd AU - Rosen T AD - Department of Obstetrics and Gynecology, Rutgers Robert Wood Johnson University Hospital, New Brunswick, NJ, USA. FAU - Palomares, Kristy AU - Palomares K AD - Department of Obstetrics and Gynecology, St. Peter's University Hospital, New Brunswick, NJ, USA. FAU - Buckley, Brian AU - Buckley B AUID- ORCID: 0000-0001-7336-4321 AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. FAU - Aleksunes, Lauren M AU - Aleksunes LM AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. AD - Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA. FAU - Barrett, Emily S AU - Barrett ES AD - Department of Biostatistics and Epidemiology, Rutgers School of Public Health, Piscataway, NJ, USA. AD - Environmental and Occupational Health Sciences Institute, Rutgers University, Piscataway, NJ, USA. LA - eng GR - P30 ES005022/ES/NIEHS NIH HHS/United States GR - R01 ES037903/ES/NIEHS NIH HHS/United States GR - T32 ES007148/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20260626 PL - United States TA - J Expo Sci Environ Epidemiol JT - Journal of exposure science & environmental epidemiology JID - 101262796 SB - IM OTO - NOTNLM OT - Biomonitoring OT - Dietary exposure OT - Mycoestrogen OT - Mycotoxin OT - Pregnancy OT - Zearalenone COIS- Competing interests: ZRN, CWK, LMA and ESB mycoestrogen work has been funded by the NIH. Other authors declare no potential competing interests. Ethical approval: All study protocols were approved by the Rutgers and SPUH Institutional Review Boards and participants signed written informed consent before engaging in any study activities. EDAT- 2026/06/27 00:49 MHDA- 2026/06/27 00:49 CRDT- 2026/06/26 23:25 PHST- 2026/03/02 00:00 [received] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/27 00:49 [medline] PHST- 2026/06/27 00:49 [pubmed] PHST- 2026/06/26 23:25 [entrez] AID - 10.1038/s41370-026-00940-0 [pii] AID - 10.1038/s41370-026-00940-0 [doi] PST - aheadofprint SO - J Expo Sci Environ Epidemiol. 2026 Jun 26. doi: 10.1038/s41370-026-00940-0. PMID- 42362794 OWN - NLM STAT- MEDLINE DCOM- 20261013 LR - 20261016 IS - 1432-1084 (Electronic) IS - 0938-7994 (Print) IS - 0938-7994 (Linking) VI - 36 IP - 11 DP - 2026 Nov TI - Does adding a high-resolution 3D sequence improve the accuracy of erosion detection in pediatric sacroiliac joint MRI? PG - 8062-8071 LID - 10.1007/s00330-026-12709-y [doi] AB - OBJECTIVE: To evaluate whether adding an erosion-sensitive high-resolution 3D sequence to sacroiliac joint (SIJ) MRI protocols in children improves erosion detection and diagnosis of Juvenile Spondyloarthritis (JSpA). MATERIALS AND METHODS: SIJ-MRI were prospectively obtained in 84 children (50 girls, mean age 13.3 y) clinically suspected of JSpA, conforming to 2024 ASAS/SPARTAN recommendations including a volumetric interpolated breath-hold examination (VIBE) sequence. Three experienced radiologists recorded the presence of erosions, non-erosion bony defects, and the presence of JSpA, with confidence scoring for each, in 3 blinded re-randomized reading exercises: (1) T1-weighted spin-echo (T1) and short-tau inversion recovery (STIR) sequences only; (2) VIBE only; (3) all sequences. Discrepancies were resolved by consensus read-out. The reference standard was rheumatologist diagnosis of JSpA. RESULTS: MRI was considered indicative of JSpA in 14 cases (16.7%) on T1/STIR, 21 (25.0%) on VIBE only, and 15 (17.9%) with all sequences. In the three exercises, erosions were scored in 12 (14.3%), 22 (26.2%), and 13 (15.5%) cases, and non-erosion bony defects in 43 (51.2%), 79 (94.0%), and 80 (95.2%) cases. Sensitivity/specificity for JSpA diagnosis was 34.6/91.4%, 42.3/82.8%, and 38.5/91.4%, after consensus read-out 38.5/94.8%. Mean absolute values of confidence scores significantly improved for all features after adding VIBE, although inter-reader agreement did not consistently improve. CONCLUSION: Adding VIBE to T1/STIR significantly increased reader confidence in JSpA diagnosis. However, a trend toward improved sensitivity and specificity was not statistically significant. If the ASAS-SPARTAN SIJ MRI protocol is applied to children, all sequences must be interpreted together to avoid mistaking non-erosion defects for true erosions. KEY POINTS: Question Can the recently published ASAS-SPARTAN adult standardized image acquisition protocol for sacroiliac joint MRI be used for diagnostic evaluation of sacroiliitis in children suspected for Juvenile Spondyloarthropathy (JSpA)? Findings The ASAS/SPARTAN recommendations including a high-resolution 3D erosion-sensitive sequence can also be applied to children, resulting in significantly increased reader confidence, with a trend toward improved sensitivity/specificity for diagnosing JSpA, although not statistically significant. Clinical relevance The ASAS-SPARTAN adult sacroiliac joint MRI protocol can also be beneficially applied to children, as long as all sequences are interpreted together to avoid mistaking non-erosion defects (almost universally seen on the 3D erosion-sensitive sequences in children) for true erosions. CI - (c) 2026. The Author(s). FAU - Herregods, Nele AU - Herregods N AUID- ORCID: 0000-0003-0244-0168 AD - Department of Radiology and Nuclear Medicine, Ghent University Hospital, Ghent, Belgium. Nele.Herregods@uzgent.be. FAU - Lambert, Robert G W AU - Lambert RGW AD - Department of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada. AD - Medical Imaging Consultants, Edmonton, Alberta, Canada. FAU - Wichuk, Stephanie AU - Wichuk S AD - Department of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada. AD - Medical Imaging Consultants, Edmonton, Alberta, Canada. FAU - Schiettecatte, Eva AU - Schiettecatte E AD - Department of Radiology and Nuclear Medicine, Ghent University Hospital, Ghent, Belgium. FAU - Renson, Thomas AU - Renson T AD - Department of Pediatric Rheumatology, Ghent University Hospital, Ghent, Belgium. FAU - Dehoorne, Joke AU - Dehoorne J AD - Department of Pediatric Rheumatology, Ghent University Hospital, Ghent, Belgium. FAU - Jans, Lennart B O AU - Jans LBO AD - Department of Radiology and Nuclear Medicine, Ghent University Hospital, Ghent, Belgium. FAU - Jaremko, Jacob L AU - Jaremko JL AD - Department of Radiology & Diagnostic Imaging, University of Alberta, Edmonton, Alberta, Canada. AD - Medical Imaging Consultants, Edmonton, Alberta, Canada. LA - eng PT - Journal Article DEP - 20260627 PL - Germany TA - Eur Radiol JT - European radiology JID - 9114774 SB - IM MH - Humans MH - Female MH - *Magnetic Resonance Imaging/methods MH - *Sacroiliac Joint/diagnostic imaging/pathology MH - Adolescent MH - *Imaging, Three-Dimensional/methods MH - Child MH - Male MH - Prospective Studies MH - Sensitivity and Specificity MH - Reproducibility of Results MH - Arthritis, Juvenile/diagnostic imaging PMC - PMC13661692 OTO - NOTNLM OT - Imaging, three-dimensional-sacroiliac joints OT - Juvenile idiopathic arthritis OT - Sacroiliitis OT - Spondyloarthropathies COIS- Compliance with ethical standards. Guarantor: The scientific guarantor of this publication is Nele Herregods. Conflict of interest: The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article. Statistics and biometry: One of the authors (Stephanie Wichuk) has significant statistical expertise. Informed consent: Written informed consent was obtained from all patients in this study and from their parents. Ethical approval: This prospective study was approved by the Ghent University Hospital Ethics Committee. Study subjects or cohorts overlap: None. Methodology: Prospective Diagnostic Observational Performed at one institution EDAT- 2026/06/27 04:10 MHDA- 2026/10/13 23:35 PMCR- 2026/06/27 CRDT- 2026/06/26 23:22 PHST- 2025/12/12 00:00 [received] PHST- 2026/06/07 00:00 [accepted] PHST- 2026/05/08 00:00 [revised] PHST- 2026/10/13 23:35 [medline] PHST- 2026/06/27 04:10 [pubmed] PHST- 2026/06/26 23:22 [entrez] PHST- 2026/06/27 00:00 [pmc-release] AID - 10.1007/s00330-026-12709-y [pii] AID - 12709 [pii] AID - 10.1007/s00330-026-12709-y [doi] PST - ppublish SO - Eur Radiol. 2026 Nov;36(11):8062-8071. doi: 10.1007/s00330-026-12709-y. Epub 2026 Jun 27. PMID- 42362717 OWN - NLM STAT- Publisher LR - 20260626 IS - 1476-5497 (Electronic) IS - 0307-0565 (Linking) DP - 2026 Jun 26 TI - Prevalence and biopsychosocial factors associated with overweight and obesity in adults with type 1 diabetes. LID - 10.1038/s41366-026-02147-7 [doi] AB - BACKGROUND: To describe the prevalence of overweight and obesity in adults living with type 1 diabetes and examine the association between biopsychosocial factors according to weight status. METHODS: A single-center, cross-sectional study was conducted in adults with type 1 diabetes attending a tertiary hospital between 2018 and 2020. Participants completed an online survey with validated questionnaires to assess physical activity; measure anxiety and depression; evaluate the perception of health-related quality of life [Spanish version of Diabetes Quality of Life Questionnaire (EsDQoL)], assess eating disorders [Spanish version of Diabetes Eating Problem Survey (EPAD-R)] and measure neuroticism. Sociodemographic data and information from the last outpatient visit regarding diabetes history, long-term complications, current insulin therapy, anthropometric measurements and laboratory data were also included. RESULTS: Data from 459 surveys were available for analysis. Participants had a mean (SD) of age of 44.7 (14.0) years; 55.6% were women; BMI 26.0 (4.7) kg/m(2) and the HbA(1c) was 7.57%. The prevalence of overweight (BMI 25-29.9 kg/m(2)) and obesity (BMI > 30 kg/m(2)) was 38.8% and 14.8%, respectively, with 10.6% being class I (30-34.9 kg/m(2)), 2.2% class II (35-39.9 kg/m(2)) and 2.0% class III (>40 kg/m(2)). Older age, living with a child/children, a higher EPAD-R score, a higher total insulin doses, receiving lipid-lowering therapy, and a higher EsDQoL score in the diabetes-related worries dimension were associated with a greater likelihood of living with obesity. CONCLUSIONS: Overweight and obesity are highly prevalent among adults living with type 1 diabetes, and the identified biopsychosocial factors reveals how excess weight arises from complex interactions among demographic, clinical, and psychological influences. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Tundidor, Diana AU - Tundidor D AUID- ORCID: 0000-0002-8629-9706 AD - Endocrinology and Nutrition Department, Obesity Section, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Endocrinology and Nutrition Department, Diabetes Unit, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Barcelona, Spain. FAU - Blanco, Jesus AU - Blanco J AD - Endocrinology and Nutrition Department, Diabetes Unit, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain. FAU - Canizares, Silvia AU - Canizares S AD - Clinical Psychology and Psychobiology Department, Section of Clinical Health Psychology, Clinical Institute of Neurosciences, Hospital Clinic de Barcelona, Barcelona, Spain. FAU - Segui, Nuria AU - Segui N AD - Endocrinology and Nutrition Department, Obesity Section, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Endocrinology and Nutrition Department, Diabetes Unit, Hospital Clinic de Barcelona, Barcelona, Spain. FAU - Obach, Amadeu AU - Obach A AD - Clinical Psychology and Psychobiology Department, Section of Clinical Health Psychology, Clinical Institute of Neurosciences, Hospital Clinic de Barcelona, Barcelona, Spain. FAU - Molero, Judith AU - Molero J AD - Endocrinology and Nutrition Department, Obesity Section, Hospital Clinic de Barcelona, Barcelona, Spain. FAU - Conget, Ignacio AU - Conget I AD - Endocrinology and Nutrition Department, Diabetes Unit, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Barcelona, Spain. AD - Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain. FAU - Gimenez, Marga AU - Gimenez M AD - Endocrinology and Nutrition Department, Diabetes Unit, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Barcelona, Spain. AD - Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain. FAU - Vidal, Josep AU - Vidal J AUID- ORCID: 0000-0002-4564-4518 AD - Endocrinology and Nutrition Department, Obesity Section, Hospital Clinic de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Barcelona, Spain. AD - Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain. FAU - Flores, Lilliam AU - Flores L AUID- ORCID: 0000-0001-5765-8813 AD - Endocrinology and Nutrition Department, Obesity Section, Hospital Clinic de Barcelona, Barcelona, Spain. lflores@clinic.cat. AD - Centro de Investigacion Biomedica en Red de Diabetes y Enfermedades Metabolicas Asociadas (CIBERDEM), Barcelona, Spain. lflores@clinic.cat. AD - Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Barcelona, Spain. lflores@clinic.cat. LA - eng PT - Journal Article DEP - 20260626 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/06/27 00:53 MHDA- 2026/06/27 00:53 CRDT- 2026/06/26 23:20 PHST- 2025/04/14 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/06/01 00:00 [revised] PHST- 2026/06/27 00:53 [medline] PHST- 2026/06/27 00:53 [pubmed] PHST- 2026/06/26 23:20 [entrez] AID - 10.1038/s41366-026-02147-7 [pii] AID - 10.1038/s41366-026-02147-7 [doi] PST - aheadofprint SO - Int J Obes (Lond). 2026 Jun 26. doi: 10.1038/s41366-026-02147-7. PMID- 42362716 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261011 IS - 1476-5497 (Electronic) IS - 0307-0565 (Print) IS - 0307-0565 (Linking) VI - 50 IP - 9 DP - 2026 Sep TI - Reassessing BMI thresholds for obesity: a population-based study in Turkish adults. PG - 1988-1994 LID - 10.1038/s41366-026-02142-y [doi] AB - BACKGROUND: The global prevalence of obesity has been steadily increasing, posing major public health challenges. Current universal BMI cut-off points may not accurately reflect obesity risk across different ethnicities, including the Turkish population. OBJECTIVE: This study aimed to evaluate the relationship between body mass index (BMI) and body fat percentage (BF%) and determine appropriate BMI cut-off points for diagnosing obesity in Turkish adults. METHODS: A cross-sectional study was conducted among Turkish individuals aged 18-65 in four major districts of Kayseri. Anthropometric measurements were obtained, including height, weight, waist circumference, and hip circumference. Body composition was assessed using bioelectrical impedance analysis (BIA). ROC (Receiver Operating Characteristic) curve analysis was performed to identify optimal BMI cut-off points for predicting obesity based on BF%. Pearson correlation analysis evaluated the relationship between BMI and BF%. RESULTS: The participants had a mean age of 39.9 +/- 13.3 years, and 51.6% were female. A strong positive correlation between BMI and BF% was found for both women (r = 0.86, p < 0.001) and men (r = 0.68, p < 0.001). The optimal BMI cut-off point for detecting obesity was 28.76 kg/m(2) for the total sample, 28.80 kg/m(2) for women, and 28.76 kg/m(2) for men. Using these new thresholds, the obesity prevalence increased from 27.7% to 33.6%. The AUC values indicated excellent discriminative power for women (AUC = 0.98) and good discriminative power for men (AUC = 0.91). CONCLUSION: The current universal BMI cut-off points (>/=30 kg/m(2)) may underestimate obesity prevalence in the Turkish population. Establishing national and gender-specific BMI thresholds could improve the accuracy of obesity diagnosis and support more effective public health interventions targeting chronic non-communicable diseases. CI - (c) 2026. The Author(s). FAU - Zeynep Ozsaydi, Semiha AU - Zeynep Ozsaydi S AUID- ORCID: 0000-0003-0065-9633 AD - Health Directorate of Kayseri, Kayseri, Turkey. FAU - Durmus, Hasan AU - Durmus H AUID- ORCID: 0000-0001-5719-1475 AD - Department of Public Health, School of Medicine, Erciyes University, Kayseri, Turkey. hasandurmus@erciyes.edu.tr. FAU - Tekdemir, Leyla AU - Tekdemir L AUID- ORCID: 0000-0002-5130-4237 AD - Health Directorate of Kayseri, Kayseri, Turkey. FAU - Ozsaydi, Seckin AU - Ozsaydi S AUID- ORCID: 0000-0001-8350-288X AD - Health Directorate of Kayseri, Kayseri, Turkey. FAU - Borlu, Arda AU - Borlu A AUID- ORCID: 0000-0002-1424-8037 AD - Department of Public Health, School of Medicine, Erciyes University, Kayseri, Turkey. FAU - Oner, Neslihan AU - Oner N AUID- ORCID: 0000-0001-6773-4963 AD - Erciyes University, Faculty of Health Sciences, Department of Nutrition and Dietetics, Kayseri, Turkey. LA - eng PT - Journal Article DEP - 20260626 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM MH - Humans MH - *Body Mass Index MH - Female MH - Turkey/epidemiology MH - Male MH - Adult MH - *Obesity/epidemiology/diagnosis MH - Cross-Sectional Studies MH - Middle Aged MH - Prevalence MH - Body Composition MH - Adolescent MH - Young Adult MH - ROC Curve MH - Electric Impedance MH - Aged MH - Waist Circumference MH - Reference Values PMC - PMC13649583 COIS- Competing interests: The authors declare no competing interests. Ethical approval: Ethical approval for this study was obtained from the Erciyes University Clinical Research Ethics Committee (Approval No: 2024/212). All methods were performed in accordance with the relevant guidelines and regulations (e.g., Declaration of Helsinki). Informed consent: Informed consent was obtained from all subjects involved in the study. Written informed consent was obtained from all participants prior to their participation in the study. EDAT- 2026/06/27 04:10 MHDA- 2026/10/09 05:30 PMCR- 2026/06/26 CRDT- 2026/06/26 23:20 PHST- 2025/04/29 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/05/13 00:00 [revised] PHST- 2026/10/09 05:30 [medline] PHST- 2026/06/27 04:10 [pubmed] PHST- 2026/06/26 23:20 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - 10.1038/s41366-026-02142-y [pii] AID - 2142 [pii] AID - 10.1038/s41366-026-02142-y [doi] PST - ppublish SO - Int J Obes (Lond). 2026 Sep;50(9):1988-1994. doi: 10.1038/s41366-026-02142-y. Epub 2026 Jun 26. PMID- 42362648 OWN - NLM STAT- Publisher LR - 20260626 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jun 26 TI - Gastric ultrasound reveals no association between prolonged fasting duration and gastric residual volume in pediatric patients. LID - 10.1038/s41598-026-57602-2 [doi] AB - Prolonged preoperative fasting is common in pediatric anesthesia, yet its effect on gastric residual volume (GRV) remains inadequately explored. We conducted a prospective cross-sectional study to examine the association between prolonged fasting duration and GRV measured using point-of-care gastric ultrasonography. A total of 491 children aged 1-12 years scheduled for elective surgery under general anesthesia after fasting more than 8 h were included. GRV was measured using point-of-care gastric ultrasonography and calculated using a validated formula, then normalized to body weight. The primary endpoint was the association between fasting duration and weight-adjusted GRV (GRV/WT). Among the participants (median age 89 months; 308 boys), fifteen patients (3.05%) had a stomach at risk of aspiration (GRV/WT > 1.25 mL kg(-1)) and 29 (5.91%) showed high-risk gastric antrum morphology. Spearman correlation analysis demonstrated no significant association between prolonged fasting duration and GRV/WT (rho = 0.037, 95% CI: - 0.054 to 0.128, p = 0.41). GRV/WT correlated positively with age and negatively with body mass index. These findings suggest that prolonged preoperative fasting does not independently associate with GRV in pediatric patients. CI - (c) 2026. The Author(s). FAU - Wu, Qingda AU - Wu Q AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Liu, Bin AU - Liu B AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. AD - Department of Anesthesiology, Heyou Hospital, Foshan, China. FAU - Wang, Zhouwu AU - Wang Z AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Chen, Lingzhi AU - Chen L AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Liu, Hao AU - Liu H AD - Department of Anesthesiology, First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China. AD - Guangzhou University of Chinese Medicine, Guangzhou, China. FAU - Zou, Qi AU - Zou Q AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Zhao, Yongzhen AU - Zhao Y AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Ding, Zhenhao AU - Ding Z AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Chen, Lu AU - Chen L AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. chenlu200505399@163.com. FAU - Zheng, Zhenwei AU - Zheng Z AD - Department of Anesthesiology, Second Affiliated Hospital of Shantou University Medical College, Shantou, China. wind_8228@163.com. LA - eng GR - No.72 [2024] - 159/Shantou Medical Health Science and Technology Project (CN)/ PT - Journal Article DEP - 20260626 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM OTO - NOTNLM OT - Fasting OT - Gastric residual volume OT - Gastric ultrasonography OT - Pediatric COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: Institutional Review Board approval was obtained. EDAT- 2026/06/27 04:10 MHDA- 2026/06/27 04:10 CRDT- 2026/06/26 23:18 PHST- 2026/03/10 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/27 04:10 [pubmed] PHST- 2026/06/26 23:18 [entrez] AID - 10.1038/s41598-026-57602-2 [pii] AID - 10.1038/s41598-026-57602-2 [doi] PST - aheadofprint SO - Sci Rep. 2026 Jun 26. doi: 10.1038/s41598-026-57602-2. PMID- 42362166 OWN - NLM STAT- MEDLINE DCOM- 20260822 LR - 20260822 IS - 1873-6513 (Electronic) IS - 0885-3924 (Linking) VI - 72 IP - 4 DP - 2026 Oct TI - Perceived Stigma, Psychological Distress, and Symptom Burden in Decompensated Cirrhosis. PG - 457-466.e2 LID - S0885-3924(26)00860-2 [pii] LID - 10.1016/j.jpainsymman.2026.06.021 [doi] AB - CONTEXT: Despite perceived stigma's impact in HIV, mental illness, and obesity, its association with adverse outcomes in decompensated cirrhosis (DC) remains under-investigated. OBJECTIVES: We aimed to quantify liver-related perceived stigma and examine its associations with patient-reported psychological distress and symptom burden among patients with DC. METHODS: We conducted a cross-sectional study of outpatients with DC from August 2018 to September 2022. Participants completed validated instruments: the four-item perceived stigma domain from the Short-Form Liver Disease Quality of Life questionnaire (range 0-100; reverse-scored where higher scores = greater stigma), the Hospital Anxiety and Depression Scale (0-21; scores >/=8: clinically significant anxiety and depression symptoms), and the Revised Edmonton Symptom Assessment System (0-100; scores >/=40: moderate-to-severe burden). We used multivariable linear regression adjusted for age, gender, etiology, and DC severity. RESULTS: Among 218/312 (70%) eligible patients (median age 60 [interquartile range 51-65]; 54% male; 58% alcohol-related; median MELD-Na 16), mean stigma score was 34.3 (standard deviation 26.3). Greater stigma was reported by those with advanced disease (Child-Pugh A vs. B vs. C: 19.4 vs. 32.2 vs. 42.2; P = 0.001) and younger patients (18-44 vs. 45-64 vs. >/=65: 38.6 vs. 37.1 vs. 26.2; P = 0.019). In adjusted analyses, greater stigma was independently associated with higher depression symptoms (beta = 0.08, P < 0.001), anxiety symptoms (beta = 0.07, P < 0.001), and symptom burden (beta = 0.33, P < 0.001). CONCLUSIONS: Among patients with DC, younger adults and those with advanced disease reported greater perceived stigma, independently associated with higher psychological distress and symptom burden. These findings highlight perceived stigma as a modifiable target for palliative care-focused interventions to improve patient-reported outcomes in DC. CI - Copyright (c) 2026 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved. FAU - Bromfield, Brittany AU - Bromfield B AD - Department of Gastroenterology and Hepatology (B.B.), Brigham and Women's Hospital, Boston, Massachusetts, USA. FAU - Zeng, Chengbo AU - Zeng C AD - Patient Reported Outcomes, Values, and Experience (PROVE) Center (C.Z.), Brigham and Women's Hospital, Boston, Massachusetts, USA. FAU - Ojeaburu, Leslie AU - Ojeaburu L AD - Department of Medicine (L.O.), Brigham and Women's Hospital, Boston, Massachusetts, USA. FAU - Mason, Nancy AU - Mason N AD - Division of Palliative Care and Geriatric Medicine (N.M., K.G.E., M.R., S.K., K.O., M.S.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Engel, Kirsten G AU - Engel KG AD - Division of Palliative Care and Geriatric Medicine (N.M., K.G.E., M.R., S.K., K.O., M.S.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Rowland, Michaela AU - Rowland M AD - Division of Palliative Care and Geriatric Medicine (N.M., K.G.E., M.R., S.K., K.O., M.S.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Kenimer, Sara AU - Kenimer S AD - Division of Palliative Care and Geriatric Medicine (N.M., K.G.E., M.R., S.K., K.O., M.S.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - O'Brien, Karen AU - O'Brien K AD - Division of Palliative Care and Geriatric Medicine (N.M., K.G.E., M.R., S.K., K.O., M.S.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Diop, Michelle S AU - Diop MS AD - Division of Palliative Care and Geriatric Medicine (N.M., K.G.E., M.R., S.K., K.O., M.S.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Donlan, John AU - Donlan J AD - Department of Internal Medicine (J.D.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Indriolo, Teresa AU - Indriolo T AD - Division of Pain Medicine (T.I.), Stanford University School of Medicine, Palo Alto, California, USA. FAU - Li, Lucinda AU - Li L AD - Department of Medicine, David Geffen School of Medicine at UCLA (L.L.), Los Angeles, California, USA. FAU - Zhu, Enya AU - Zhu E AD - Department of Medicine, Duke University School of Medicine (E.Z.), Durham, North Carolina, USA. FAU - Armstrong, Malia E AU - Armstrong ME AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Bizup, Grace AU - Bizup G AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Munroe, Will AU - Munroe W AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Dalvi, Anushka AU - Dalvi A AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Li, Xing AU - Li X AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Lau-Min, Kelsey S AU - Lau-Min KS AD - Division of Hematology and Oncology (K.S.L., A.E.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Brown, Cristal AU - Brown C AD - Department of Internal Medicine (C.B.), University of Texas at Austin Dell Medical School, Austin, Texas, USA. FAU - Zhang, Wei AU - Zhang W AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - El-Jawahri, Areej AU - El-Jawahri A AD - Division of Hematology and Oncology (K.S.L., A.E.), Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Ufere, Nneka N AU - Ufere NN AD - Gastrointestinal Division (M.E.A., G.B., W.M., A.D., X.L., W.Z., N.N.U.), Liver Center, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address: nneka.ufere@mgh.harvard.edu. LA - eng PT - Journal Article DEP - 20260626 PL - United States TA - J Pain Symptom Manage JT - Journal of pain and symptom management JID - 8605836 SB - IM MH - Humans MH - Male MH - Female MH - Symptom Burden MH - *Liver Cirrhosis/psychology MH - Cross-Sectional Studies MH - Middle Aged MH - Aged MH - *Psychological Distress MH - *Social Stigma MH - Quality of Life MH - Depression MH - Anxiety MH - Severity of Illness Index OTO - NOTNLM OT - Decompensated cirrhosis OT - anxiety OT - depression OT - patient-reported outcomes OT - stigma OT - symptom burden EDAT- 2026/06/27 00:52 MHDA- 2026/08/22 23:43 CRDT- 2026/06/26 19:35 PHST- 2026/04/27 00:00 [received] PHST- 2026/06/17 00:00 [revised] PHST- 2026/06/23 00:00 [accepted] PHST- 2026/08/22 23:43 [medline] PHST- 2026/06/27 00:52 [pubmed] PHST- 2026/06/26 19:35 [entrez] AID - S0885-3924(26)00860-2 [pii] AID - 10.1016/j.jpainsymman.2026.06.021 [doi] PST - ppublish SO - J Pain Symptom Manage. 2026 Oct;72(4):457-466.e2. doi: 10.1016/j.jpainsymman.2026.06.021. Epub 2026 Jun 26. PMID- 42361874 OWN - NLM STAT- MEDLINE DCOM- 20260809 LR - 20260831 IS - 1096-0953 (Electronic) IS - 0013-9351 (Linking) VI - 306 IP - Pt 1 DP - 2026 Sep 15 TI - Effects of a walk in a residential natural vs. urban environment on objective and subjective stress indicators in mothers and their infants. PG - 125125 LID - S0013-9351(26)01456-8 [pii] LID - 10.1016/j.envres.2026.125125 [doi] AB - Despite growing evidence that being in nature positively influences mood and stress, its effects on children are not well understood. Previous cross-sectional research suggests that greater green space in children's residential environments is associated with better mental health outcomes, but the causal relationship remains unclear. Moreover, the impact of such environments on infants has not yet been explored. To address these gaps, we conducted an experimental intervention study with 72 mother-infant dyads (mean infant age = 7.5 months) to examine the effects of natural vs. urban environments on their stress. To enhance ecological validity, the study took place in residential, everyday environments, and the walks were conducted independently of the experimenter team. The study employed a randomised crossover trial, in which each mother-infant pair completed two 45-min walks, one in a natural setting and one in an urban area. We assessed subjective and physiological stress indicators, including maternal self-reported stress, salivary cortisol in mothers and infants, and cortisol levels in mothers' breast milk. The results showed that mothers' subjective stress levels decreased after both walks (p = 0.001), accompanied by a reduction in arousal (p < 0.001). Additionally, salivary cortisol concentrations decreased after walks in both environments for mothers (p = 0.007) and infants (p = 0.007). Mothers further reported increased calmness (p = 0.001), greater pleasantness (p = 0.002), and improved mood (p < 0.001) after the both walks, while also rating the nature walk as more enjoyable (p < 0.001) and more attention-restorative (p < 0.001) than the urban walk. However, the type of environment did not significantly affect subjective or physiological stress levels in mothers and infants. These findings suggest that taking a walk outdoors was associated with reduced stress in mothers and infants, but that the environment may play less of a role in this effect. The results underscore the complex relationship between environmental exposure and stress, offering insights for future research into how different environments influence early-life stress regulation. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Sudimac, Sonja AU - Sudimac S AD - Max Planck Institute for Human Development, Center for Environmental Neuroscience, Lentzeallee 94, Berlin, 14195, Germany. Electronic address: sudimac@mpib-berlin.mpg.de. FAU - Drewelies, Johanna AU - Drewelies J AD - Max Planck Institute for Human Development, Center for Environmental Neuroscience, Lentzeallee 94, Berlin, 14195, Germany. FAU - de Weerth, Carolina AU - de Weerth C AD - Radboud University Medical Center, Donders Institute for Brain, Cognition and Behaviour, Kapittelweg 29, Nijmegen, 6525 GD, the Netherlands. FAU - Kuhn, Simone AU - Kuhn S AD - Max Planck Institute for Human Development, Center for Environmental Neuroscience, Lentzeallee 94, Berlin, 14195, Germany; University Medical Center Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Martinistr. 52, Hamburg, 20251, Germany; Max Planck UCL Centre for Computational Psychiatry and Ageing Research Berlin, Germany and London, UK, Lentzeallee 94, Berlin, 14195, Germany; Psychiatric Environmental Neuroscience (PEN), Clinic for Psychiatry CCM, Charite - Universitatsmedizin Berlin, Corporate Member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Bonhoefferweg 3, Berlin, 10117, Germany. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260626 PL - Netherlands TA - Environ Res JT - Environmental research JID - 0147621 RN - WI4X0X7BPJ (Hydrocortisone) SB - IM MH - Humans MH - Female MH - *Walking MH - Infant MH - *Mothers/psychology MH - Hydrocortisone/analysis MH - Adult MH - Subjective Stress MH - *Stress, Psychological MH - Saliva/chemistry MH - Cross-Over Studies MH - Milk, Human/chemistry MH - Urban Population MH - Male MH - Stress, Physiological OTO - NOTNLM OT - Cortisol OT - Environment OT - Infants OT - Natural OT - Stress OT - Urban OT - Walk COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/27 00:53 MHDA- 2026/08/10 00:40 CRDT- 2026/06/26 19:31 PHST- 2025/11/30 00:00 [received] PHST- 2026/06/09 00:00 [revised] PHST- 2026/06/26 00:00 [accepted] PHST- 2026/08/10 00:40 [medline] PHST- 2026/06/27 00:53 [pubmed] PHST- 2026/06/26 19:31 [entrez] AID - S0013-9351(26)01456-8 [pii] AID - 10.1016/j.envres.2026.125125 [doi] PST - ppublish SO - Environ Res. 2026 Sep 15;306(Pt 1):125125. doi: 10.1016/j.envres.2026.125125. Epub 2026 Jun 26. PMID- 42361335 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260627 LR - 20260813 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 9 DP - 2026 Jun 26 TI - Codevelopment of a Digital Screening and Intervention Tool to Improve Lifestyle Habits in Children: Focus Group Study With Parents and Clinicians. PG - e84304 LID - 10.2196/84304 [doi] LID - e84304 AB - BACKGROUND: Chronic preventable diseases represent a major burden in Canada, often rooted in unhealthy behaviors established during childhood. Despite recommendations for routine screening, most children are not assessed due to clinical barriers. This paper presents the early development of Project DISCO, a self-administered, digital preappointment tool to screen for and support healthy lifestyle behaviors, including physical activity, sleep, nutrition, and screen time, in children aged 2 to 12 years. OBJECTIVE: This study aimed to explore clinicians' and parents' needs and past experiences with health technology; integrate their insights into the development of a digital tool for promoting health behaviors; and evaluate the usability, relevance, and acceptability of this tool. METHODS: Three semistructured focus group and interview sessions were conducted with primary care clinicians and parents. Participants were recruited at the Groupe de Medecine de Famille Universitaire Saint-Hubert using purposive and convenience sampling: clinicians were recruited internally, whereas parents of children aged 2 to 12 years were invited via emails sent by clinic staff. Data were analyzed using a combination of inductive and deductive approaches. Findings informed iterative refinements throughout the codevelopment of the digital tool for promoting healthy lifestyle behaviors in children. RESULTS: A total of 8 participants took part in 6 discussions, including 5 parents of children aged 3 to 12 years and 3 primary care clinicians. Hybrid thematic analysis identified six themes: (1) the potential of a digital tool to promote healthy habits in pediatrics; (2) implementation challenges and opportunities, including integration of the tool into clinical workflow; (3) adherence to and engagement with the tool, with suggestions for reminders and involvement of nurses; (4) perceived limitations and improvement of the screening tool, particularly the nutrition and sleep questionnaires; (5) feedback on the screening report and intervention emphasizing clarity and actionable guidance; and (6) perceived clinical value and opportunity costs. Insights from these discussions guided refinements of the digital tool. CONCLUSIONS: The findings support the tool's relevance and inform its ongoing development. A feasibility study is planned prior to a randomized controlled trial. CI - (c)Alice Moyne, Tamara Perez, Trevor van Mierlo, Maryam Kebbe, Olivier Drouin. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org), 26.06.2026. FAU - Moyne, Alice AU - Moyne A AUID- ORCID: 0009-0008-0239-5954 AD - Department of Nutrition, Universite de Montreal, Montreal, QC, Canada. AD - Centre de recherche Azrieli du Centre Hospitalier Universitaire Sainte-Justine, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada. AD - Departement Prevention Cancer Environnement, Centre Leon Berard, Lyon, Auvergne-Rhone-Alpes, France. FAU - Perez, Tamara AU - Perez T AUID- ORCID: 0000-0002-9892-3043 AD - Centre de recherche Azrieli du Centre Hospitalier Universitaire Sainte-Justine, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada. FAU - van Mierlo, Trevor AU - van Mierlo T AUID- ORCID: 0000-0002-5675-0084 AD - Evolution Health, Toronto, ON, Canada. FAU - Kebbe, Maryam AU - Kebbe M AUID- ORCID: 0000-0001-7999-9299 AD - Faculty of Kinesiology, University of New Brunswick, Fredericton, NB, Canada. FAU - Drouin, Olivier AU - Drouin O AUID- ORCID: 0000-0003-1429-9341 AD - Department of Nutrition, Universite de Montreal, Montreal, QC, Canada. AD - Centre de recherche Azrieli du Centre Hospitalier Universitaire Sainte-Justine, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada. AD - Department of Pediatrics, Universite de Montreal, Montreal, QC, Canada. AD - Department of Pediatrics, Division of Pediatrics, Centre Hospitalier Universitaire Sainte-Justine, Montreal, QC, Canada. AD - Department of Social and Preventive Medicine, School of Public Health, Universite de Montreal, Montreal, QC, Canada. LA - eng PT - Journal Article DEP - 20260626 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC13354948 OTO - NOTNLM OT - digital tool OT - intervention OT - lifestyle behavior OT - pediatrics OT - qualitative study OT - screening COIS- Conflicts of Interest: None declared. EDAT- 2026/06/27 04:10 MHDA- 2026/06/27 04:11 PMCR- 2026/06/26 CRDT- 2026/06/26 16:53 PHST- 2025/09/17 00:00 [received] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/04/16 00:00 [revised] PHST- 2026/06/27 04:11 [medline] PHST- 2026/06/27 04:10 [pubmed] PHST- 2026/06/26 16:53 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - v9i1e84304 [pii] AID - 10.2196/84304 [doi] PST - epublish SO - JMIR Pediatr Parent. 2026 Jun 26;9:e84304. doi: 10.2196/84304. PMID- 42361330 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 28 DP - 2026 Jun 26 TI - Digital Interventions Targeting Parents to Improve Early Childhood Movement, Nutrition, and Sleep Behaviors: Systematic Review. PG - e85525 LID - 10.2196/85525 [doi] LID - e85525 AB - BACKGROUND: Early childhood (0-5 years) is key for shaping health behaviors, yet optimal behaviors are rarely achieved. Digital health promotion interventions offer scalable support for families; however, most research has focused on childhood more broadly, leaving limited evidence for the early childhood period. OBJECTIVE: The primary aim of this systematic review was to examine whether autonomously delivered digital interventions targeting parents are effective at increasing physical activity, reducing sedentary behavior, improving nutrition (breastfeeding, feeding practices), and/or optimizing sleep among children aged 0-5 years. The secondary aim was to review the reporting of co-design practices, user engagement, and process evaluation, and to assess how engagement influences intervention effectiveness. METHODS: Seven databases were searched for randomized controlled trials (RCTs) evaluating autonomously delivered digital interventions targeting one or more of the following behaviors: physical activity, sedentary behavior, nutrition, or sleep among children (published to January 2026). Study quality was assessed using the Joanna Briggs Institute Critical Appraisal Checklist for RCTs. Findings were narratively synthesized by target age-group and behavior, and the direction of effect was summarized in structured tables. RESULTS: Of the 14,352 identified records, 38 interventions (33 RCTs, 4 pilot RCTs, and 1 feasibility RCT) were included. Most studies focused on pregnancy to infancy (n=24; 0-1 y), followed by preschoolers (n=8; 3-5 y) and toddlers (n=6; 1-2 y). Intervention duration ranged from 2 weeks to 1000 days, and various digital formats were used (apps n=11, SMS text messaging n=10, web- or internet-based platforms n=6, WeChat [Tencent] n=3, tablet-based program n=2, a combination of app and SMS text messaging n=1, website and emails n=1, emails and SMS text messaging n=1, automated voice calls n=1, Facebook Messenger Chatbot [Meta] n=1, and online videos n=1). Interventions spanning pregnancy to infancy reported mixed findings for breastfeeding and feeding practices. Studies targeting toddlers showed improvements in sleep, mixed findings for diet and screen time, and no differences in physical activity. Most studies targeting preschoolers reported significant improvements for feeding practices and diet, but no differences in physical activity, sedentary behavior and sleep, and mixed findings for screen time. Most studies reported co-design or engagement (n=24), but few examined the impact of engagement on intervention effectiveness (n=6), and those that did reported mixed findings. Interpretation was limited by heterogeneous designs, inconsistent outcome measures, and mixed risk-of-bias ratings across studies. CONCLUSIONS: This review advances the field by synthesizing evidence on scalable digital interventions that support parents in promoting healthy lifestyle behaviors across the first 2000 days, together with key design and implementation factors that have rarely been reported in previous reviews. Unlike prior work, it focuses exclusively on autonomously delivered digital interventions in early childhood. Findings show heterogeneous designs and mixed effectiveness, and highlight 3 priority evidence gaps: limited studies in toddlers and preschoolers, incomplete reporting of engagement, and limited understanding of how engagement influences outcomes. These findings define priorities for future research to strengthen the evidence for scalable digital interventions in early childhood. CI - (c) Johanna Sandborg, Brittany L Reese, Sarah Marshall, Kylie D Hesketh, Rachel Laws, Katherine L Downing. Originally published in the Journal of Medical Internet Research (https://www.jmir.org). FAU - Sandborg, Johanna AU - Sandborg J AUID- ORCID: 0000-0003-0389-9333 AD - Institute for Physical Activity and Nutrition (IPAN), Faculty of Health, Deakin University, Locked Bag 20000, Geelong, VIC, 3220, Australia, +46 733285912. FAU - Reese, Brittany L AU - Reese BL AUID- ORCID: 0000-0001-6242-0842 AD - Institute for Physical Activity and Nutrition (IPAN), Faculty of Health, Deakin University, Locked Bag 20000, Geelong, VIC, 3220, Australia, +46 733285912. FAU - Marshall, Sarah AU - Marshall S AUID- ORCID: 0000-0002-1462-3087 AD - Institute for Physical Activity and Nutrition (IPAN), Faculty of Health, Deakin University, Locked Bag 20000, Geelong, VIC, 3220, Australia, +46 733285912. AD - Sydney School of Public Health, The University of Sydney, Sydney, Australia. FAU - Hesketh, Kylie D AU - Hesketh KD AUID- ORCID: 0000-0002-2702-7110 AD - Institute for Physical Activity and Nutrition (IPAN), Faculty of Health, Deakin University, Locked Bag 20000, Geelong, VIC, 3220, Australia, +46 733285912. FAU - Laws, Rachel AU - Laws R AUID- ORCID: 0000-0003-4328-1116 AD - Institute for Physical Activity and Nutrition (IPAN), Faculty of Health, Deakin University, Locked Bag 20000, Geelong, VIC, 3220, Australia, +46 733285912. FAU - Downing, Katherine L AU - Downing KL AUID- ORCID: 0000-0002-6552-8506 AD - Institute for Physical Activity and Nutrition (IPAN), Faculty of Health, Deakin University, Locked Bag 20000, Geelong, VIC, 3220, Australia, +46 733285912. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260626 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 SB - IM MH - Humans MH - *Sleep MH - Child, Preschool MH - *Parents MH - Infant MH - Female MH - *Exercise MH - *Health Promotion/methods MH - Digital Health MH - Digital Media MH - Infant, Newborn MH - Sedentary Behavior MH - Breast Feeding MH - *Health Behavior MH - *Nutritional Status MH - Randomized Controlled Trials as Topic PMC - PMC13309061 OTO - NOTNLM OT - breastfeeding OT - diet OT - digital OT - eHealth OT - mHealth OT - movement behaviours OT - physical activity OT - screen time OT - sedentary behaviour COIS- Conflicts of Interest: JS is a founder of Science4Families AB, but this company had no role in this research. No other disclosures were reported. EDAT- 2026/06/27 04:10 MHDA- 2026/06/27 18:37 PMCR- 2026/06/26 CRDT- 2026/06/26 16:52 PHST- 2025/10/08 00:00 [received] PHST- 2026/04/03 00:00 [revised] PHST- 2026/04/06 00:00 [accepted] PHST- 2026/06/27 18:37 [medline] PHST- 2026/06/27 04:10 [pubmed] PHST- 2026/06/26 16:52 [entrez] PHST- 2026/06/26 00:00 [pmc-release] AID - v28i1e85525 [pii] AID - 85525 [pii] AID - 10.2196/85525 [doi] PST - epublish SO - J Med Internet Res. 2026 Jun 26;28:e85525. doi: 10.2196/85525. PMID- 42359683 OWN - NLM STAT- Publisher LR - 20260626 IS - 1536-0911 (Electronic) IS - 1536-0903 (Linking) DP - 2026 Jun 26 TI - NICU Nurses' Attitudes Toward Adopting an Evidence-Based Practice Intervention to Improve Bone Mineralization in Preterm Infants. LID - 10.1097/ANC.0000000000001397 [doi] AB - BACKGROUND: Metabolic bone disease (MBD) is a disorder affecting bone mineralization that leads to short and long-term consequences. A daily exercise regimen consisting of passive range of motion (ROM) and gentle compression of upper and lower extremities shows promising results in improving bone mineralization in preterm infants. However, the lack of nursing literature suggests that nurses may underutilize these interventions. PURPOSE: This study examined Neonatal Intensive Care Unit (NICU) nurses' attitudes toward adopting passive ROM and gentle compression to improve bone mineralization in preterm infants and explored whether knowledge of MBD influences the implementation of these practices. METHODS: A quantitative, descriptive, cross-sectional survey of 238 NICU nurses was conducted. The Evidence-Based Practice Attitude Scale (EBPAS) assessed attitudes toward evidence-based interventions. Additional questions evaluated nurses' knowledge of MBD and their use of passive ROM and gentle compression in clinical practice. RESULTS: Results showed favorable attitudes toward evidence-based practice (EBPAS M = 2.92, SD = 0.565). In this sample, 23.1% of nurses reported routinely performing passive ROM, and 7.2% reported performing gentle compression of upper and lower extremities. The EBPAS demonstrated high reliability (alpha = 0.884) and strong convergent validity (r = 0.633). No significant differences were found by years of experience (P = .55) or certification (P = .39). Over half of respondents lacked knowledge about MBD etiology (53.4%) and prevention/treatment (59.7%). IMPLICATIONS FOR PRACTICE AND RESEARCH: Findings highlight a knowledge gap despite positive attitudes. Incorporating MBD education and exercise techniques into NICU training may help standardize these evidence-based interventions and improve outcomes for preterm infants. CI - Copyright (c) 2026 by The National Association of Neonatal Nurses. FAU - Melendez Vassall, Idamis AU - Melendez Vassall I AUID- ORCID: 0009-0006-3763-3508 AD - Author Affiliations: The Barbara H. Hagan School of Nursing & Health Sciences, Molloy University, Rockville Centre, New York (Melendez Vassall and Mannino); Northwell Health, North Shore University Hospital, Manhasset, New York (Melendez Vassall and Perveen); and Office of Research and Scholarship, Molloy University, Rockville Centre, New York, New York (Watters). FAU - Mannino, Jennifer Emilie AU - Mannino JE AUID- ORCID: 0000-0001-9238-2293 FAU - Watters, Pamela AU - Watters P FAU - Perveen, Shahana AU - Perveen S LA - eng PT - Journal Article DEP - 20260626 PL - United States TA - Adv Neonatal Care JT - Advances in neonatal care : official journal of the National Association of Neonatal Nurses JID - 101125644 SB - IM OTO - NOTNLM OT - bone mineralization OT - evidence-based practice attitudes scale (EBPAS) OT - gentle compression OT - metabolic bone disease OT - nurse attitude OT - premature infant OT - range of motion EDAT- 2026/06/27 04:10 MHDA- 2026/06/27 04:10 CRDT- 2026/06/26 06:04 PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/27 04:10 [pubmed] PHST- 2026/06/26 06:04 [entrez] AID - 00149525-990000000-00284 [pii] AID - 10.1097/ANC.0000000000001397 [doi] PST - aheadofprint SO - Adv Neonatal Care. 2026 Jun 26. doi: 10.1097/ANC.0000000000001397. PMID- 42359254 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 1664-042X (Print) IS - 1664-042X (Electronic) IS - 1664-042X (Linking) VI - 17 DP - 2026 TI - Obesity is associated with suppressed bone turnover: a systematic review and meta-analysis. PG - 1793838 LID - 10.3389/fphys.2026.1793838 [doi] LID - 1793838 AB - BACKGROUND: Obesity is an increasingly serious public health issue on a global scale. Although there is increasing research on the relationship between obesity and biochemical markers of bone turnover, this relationship is complex and unclear. We conducted a systematic review and meta-analysis aimed at comparing the concentrations of biochemical markers of bone turnover between individuals with obesity and those with normal-weight. METHOD: A systematic search was conducted using the PubMed, EMBASE, Web of Science, Cochrane Library, and EBSCO databases from database inception to December 15, 2025. Two researchers screened the literature according to the inclusion and exclusion criteria and extracted valid data for quality evaluation. RESULTS: The results ultimately included 14 articles with a total of 4612 subjects. Compared with normal-weight individuals, individuals with obesity showed no significant difference in alkaline phosphatase (ALP) levels. Procollagen type I N-terminal propeptide (PINP) levels were significantly reduced in individuals with obesity. Osteocalcin (OCN) levels were also decreased overall, but subgroup analysis showed that this reduction was significant in children and adolescents, whereas no significant difference was observed in adults. No significant difference was observed in C-terminal telopeptide of type I collagen (CTX-I) or N-terminal telopeptide of type I collagen (NTX) levels. CONCLUSION: This meta-analysis suggests that obesity is associated with suppressed bone turnover, mainly reflected by reduced levels of bone formation markers. PINP levels were significantly decreased in individuals with obesity, whereas the reduction in OCN appeared to be age-dependent, with significant suppression observed in children and adolescents but not in adults. However, the robustness of the bone resorption results is insufficient and requires further validation through additional studies. Further studies are needed to clarify the mechanisms by which obesity affects skeletal health and to identify potential targets for clinical intervention. CI - Copyright (c) 2026 Lin, Liu, Chen and Liu. FAU - Lin, Haiqi AU - Lin H AD - School of Physical Education and Sports Science, South China Normal University, Guangzhou, Guangdong, China. AD - College of Physical Education, South China University of Technology, Guangzhou, Guangdong, China. FAU - Liu, Xiaohua AU - Liu X AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Chen, Binglin AU - Chen B AD - The Second School of Clinical Medical College, Xuzhou Medical University, Xuzhou, Jiangsu, China. FAU - Liu, Chengyi AU - Liu C AD - School of Physical Education and Sports Science, South China Normal University, Guangzhou, Guangdong, China. LA - eng PT - Journal Article PT - Review DEP - 20260610 PL - Switzerland TA - Front Physiol JT - Frontiers in physiology JID - 101549006 PMC - PMC13290598 OTO - NOTNLM OT - bone OT - bone formation OT - bone resorption OT - bone turnover (markers) OT - obesity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/26 06:38 MHDA- 2026/06/26 06:39 PMCR- 2026/06/10 CRDT- 2026/06/26 04:45 PHST- 2026/01/22 00:00 [received] PHST- 2026/05/28 00:00 [revised] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/06/26 06:39 [medline] PHST- 2026/06/26 06:38 [pubmed] PHST- 2026/06/26 04:45 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.3389/fphys.2026.1793838 [doi] PST - epublish SO - Front Physiol. 2026 Jun 10;17:1793838. doi: 10.3389/fphys.2026.1793838. eCollection 2026. PMID- 42359124 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - The association between urban-rural disparities and emotional regulation abilities among first-year college students: a statistical indirect effects analysis of psychological and social competence. PG - 1836842 LID - 10.3389/fpubh.2026.1836842 [doi] LID - 1836842 AB - BACKGROUND: University students' emotional regulation abilities are crucial to their mental health. Existing research suggests that urban and rural backgrounds may be associated with emotional regulation among freshmen; however, the underlying mechanisms of this association remain unclear. Drawing on resource conservation theory and the bio-psycho-social model, this study examines whether psychological and social fitness exert statistical indirect effects on the relationship between urban-rural differences and emotional regulation. METHODS: A cross-sectional design was employed to conduct a questionnaire survey of 6,718 first-year students at a comprehensive university. The measurement instruments included the Emotion Regulation Questionnaire, the Emotion Regulation Difficulty Scale, and the Health Adaptation Scale. Control variables included gender, age, single-parent family status, and experience as a left-behind child. Structural Equation Modeling (SEM) was employed to conduct a multiple mediation analysis, and the Bootstrap method was used to test statistical indirect effects, with a focus on the statistical indirect effects of psychological and social fitness. As this study employed a cross-sectional design with a sample drawn from a single university, the statistical indirect effects revealed reflect only statistical associations between variables and do not allow for inferences of causal relationships. RESULTS: Rural freshmen exhibited significantly greater difficulties in emotional regulation than their urban counterparts, and both psychological and social fitness were significantly lower. Physical fitness was also significantly lower among rural freshmen. Physical, psychological, and social fitness all exhibited significant statistical indirect effects on the urban-rural differences and the three emotional regulation indicators. Multiple mediation analyses revealed that psychological adaptability had the strongest statistical indirect association with difficulties in emotional regulation; social fitness had relatively stronger statistical indirect associations with cognitive reappraisal and expressive suppression; physical fitness showed statistically significant but comparatively smaller indirect effects. The results remained robust after controlling for single-parent family status and experience as a left-behind child. The effect sizes of urban-rural differences across variables ranged from 0.05 to 0.24, falling within the small-effect range; statistical significance should not be equated with practical significance, and urban-rural background itself has limited explanatory power for differences in emotional regulation. CONCLUSION: Within the scope of this study, the association between urban-rural disparities and emotional regulation can be explained by the statistical indirect effects of physical, psychological, and social fitness, which serve as the three primary statistical indirect effect pathways. The study indicates that the association between urban-rural differences and emotional regulation is statistically mediated by individuals' physical, psychological, and social competence resources, providing preliminary exploratory targets for mental health interventions in higher education institutions. However, given the cross-sectional nature of the study, these conclusions require further validation through longitudinal research. CI - Copyright (c) 2026 Chen, Zhang, Wang and Liu. FAU - Chen, Leqin AU - Chen L AD - Shanxi Normal University, Taiyuan, China. FAU - Zhang, Qingtong AU - Zhang Q AD - Shanxi Normal University, Taiyuan, China. FAU - Wang, YiXia AU - Wang Y AD - Shanxi Normal University, Taiyuan, China. FAU - Liu, Chang AU - Liu C AD - Shanxi Normal University, Taiyuan, China. LA - eng PT - Journal Article DEP - 20260610 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - *Students/psychology/statistics & numerical data MH - *Urban Population/statistics & numerical data MH - *Rural Population/statistics & numerical data MH - Male MH - *Emotional Regulation MH - Universities MH - Surveys and Questionnaires MH - Young Adult MH - Adolescent PMC - PMC13290984 OTO - NOTNLM OT - emotional regulation OT - first-year college students OT - psychological fitness OT - social fitness OT - urban-rural disparities COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/26 06:39 MHDA- 2026/06/27 07:10 PMCR- 2026/06/10 CRDT- 2026/06/26 04:44 PHST- 2026/03/23 00:00 [received] PHST- 2026/05/17 00:00 [revised] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 06:39 [pubmed] PHST- 2026/06/26 04:44 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1836842 [doi] PST - epublish SO - Front Public Health. 2026 Jun 10;14:1836842. doi: 10.3389/fpubh.2026.1836842. eCollection 2026. PMID- 42358574 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Urinary fatty acid binding protein 2 as a biomarker of intestinal injury in pediatric celiac disease. PG - 1838294 LID - 10.3389/fped.2026.1838294 [doi] LID - 1838294 AB - OBJECTIVES: Celiac disease (CeD) is an autoimmune enteropathy triggered by gluten in genetically predisposed individuals, causing intestinal damage and impaired gut barrier integrity. Current diagnostic methods, such as serology and intestinal biopsy, are costly and invasive. Intestinal fatty acid binding protein (FABP2), exclusively expressed in the cytosol of mature enterocytes and released during injury, offers a potential non-invasive alternative biomarker. This study aimed to evaluate urinary FABP2 levels in pediatric patients undergoing gastrointestinal assessment or CeD follow-up to determine its potential as a non-invasive biomarker of intestinal integrity. METHODS: In this retrospective cross-sectional study, urinary FABP2 was measured in 103 pediatric patients evaluated for intestinal permeability using the lactulose/mannitol test. Based on serology and symptomatology, patients were categorized as controls (n = 65), CeD on gluten-free diet (GFD) > 6 months (n = 26), or active CeD (n = 12). Associations between FABP2 levels, serology, symptoms, and diagnosis were analyzed. RESULTS: FABP2 levels were significantly elevated in active CeD patients (47.7 pg/mL) compared with controls (9.65 pg/mL) (p < 0.05), but not in CeD patients on GFD (15.0 pg/mL). A receiver operating characteristic curve analysis confirmed the diagnostic potential of FABP2 as a biomarker for celiac disease (area under the curve = 0.7269; cutoff = 23.7 pg/mL; sensitivity = 66.7%, specificity = 76.9%). CONCLUSION: Our findings indicate that urinary FABP2 reflects intestinal epithelial injury and may serve as a non-invasive biomarker for assessing gut integrity and disease activity in CeD. However, larger prospective studies with histological correlation are needed to validate its diagnostic utility. CI - (c) 2026 Mehta, Kapoor, Milliron, Stoeckel, Ballelos, Tiqui, Deb, Abomoelak, Schreck and Mehta. FAU - Mehta, Vijay AU - Mehta V AD - Pediatric Gastroenterology, Orlando Health Arnold Palmer Hospital for Children, Orlando, FL, United States. FAU - Kapoor, Nidhi AU - Kapoor N AD - Specialty Diagnostic Clinical and Translational Research Lab, Orlando Health Arnold Palmer Hospital for Children, Orlando, FL, United States. FAU - Milliron, Chloe AU - Milliron C AD - University of Central Florida, Orlando, FL, United States. FAU - Stoeckel, Noah AU - Stoeckel N AD - Specialty Diagnostic Clinical and Translational Research Lab, Orlando Health Arnold Palmer Hospital for Children, Orlando, FL, United States. FAU - Ballelos, Edwin AU - Ballelos E AD - University of Central Florida, Orlando, FL, United States. FAU - Tiqui, Katrina AU - Tiqui K AD - University of Central Florida, Orlando, FL, United States. FAU - Deb, Chirajyoti AU - Deb C AD - University of Central Florida, Orlando, FL, United States. FAU - Abomoelak, Bassam AU - Abomoelak B AD - Specialty Diagnostic Clinical and Translational Research Lab, Orlando Health Arnold Palmer Hospital for Children, Orlando, FL, United States. FAU - Schreck, Mary AU - Schreck M AD - Orlando Health Medical Group Pediatric Specialty Practice Resources, Orlando, FL, United States. FAU - Mehta, Devendra AU - Mehta D AD - Pediatric Gastroenterology, Orlando Health Arnold Palmer Hospital for Children, Orlando, FL, United States. LA - eng PT - Journal Article DEP - 20260610 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13290442 OTO - NOTNLM OT - autoimmune enteropathy OT - biomarker OT - intestinal integrity OT - intestinal permeability test OT - leaky gut OT - mucosal damage COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/26 16:11 PMCR- 2026/06/10 CRDT- 2026/06/26 04:38 PHST- 2026/03/25 00:00 [received] PHST- 2026/05/19 00:00 [revised] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/26 16:11 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 04:38 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.3389/fped.2026.1838294 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 10;14:1838294. doi: 10.3389/fped.2026.1838294. eCollection 2026. PMID- 42358305 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Comparative evaluation of nutritional risk screening tools in hospitalized children with acute gastroenteritis. PG - 1841518 LID - 10.3389/fnut.2026.1841518 [doi] LID - 1841518 AB - BACKGROUND: Malnutrition is common in hospitalized children with acute gastroenteritis, yet the optimal nutritional risk screening tool for this population remains unclear. This study aimed to compare the diagnostic performance and clinical utility of STRONGkids, PYMS, and STAMP in identifying malnutrition among hospitalized children with acute gastroenteritis. METHODS: In this multicenter retrospective study, children hospitalized with acute gastroenteritis between January 2024 and January 2026 were identified from electronic medical records at admission. After exclusions, 855 children were included in the final analysis. Nutritional risk was retrospectively assessed using STRONGkids, PYMS, and STAMP. Nutritional status was classified according to body mass index-for-age z scores based on the World Health Organization growth reference. Receiver operating characteristic curve analysis was used to evaluate discriminatory performance, with pairwise comparisons performed using the DeLong test. Optimal cut-off values were determined using the Youden index, and decision curve analysis was performed to assess clinical utility. RESULTS: Of the 855 children included, 82 were malnourished and 773 had normal nutritional status. Compared with children with normal nutritional status, malnourished children were younger and had more vomiting and diarrhea episodes, longer hospital stay, higher screening scores, and more severe dehydration. PYMS showed the best discriminatory performance, with an AUC of 0.860 (95% CI, 0.824-0.896), followed by STAMP at 0.796 (95% CI, 0.748-0.845) and STRONGkids at 0.717 (95% CI, 0.658-0.776). PYMS performed significantly better than both STRONGkids and STAMP, and STAMP also outperformed STRONGkids. At the optimal cut-off of 3, PYMS had the highest sensitivity, specificity, Youden index, and negative predictive value. Decision curve analysis also supported the superior clinical utility of PYMS. CONCLUSION: Among the three screening tools, PYMS demonstrated the best overall performance for identifying malnutrition in hospitalized children with acute gastroenteritis and may be the most suitable tool for early nutritional risk screening in this population. CI - Copyright (c) 2026 Zhao, Li, Lin, Zhang, Li, Liu, Zhao and Mao. FAU - Zhao, Yue AU - Zhao Y AD - Department of Nursing, Lianyungang Maternity and Child Health Hospital, Lianyungang, Jiangsu, China. FAU - Li, Ziyang AU - Li Z AD - Department of Pediatrics, The First People's Hospital of Xuzhou, Xuzhou, Jiangsu, China. FAU - Lin, Mingyue AU - Lin M AD - Department of Pediatrics, The Affiliated Lianyungang Hospital of Xuzhou Medical University (The First People's Hospital of Lianyungang), Lianyungang, Jiangsu, China. FAU - Zhang, Juan AU - Zhang J AD - Department of Nursing, Lianyungang Maternity and Child Health Hospital, Lianyungang, Jiangsu, China. FAU - Li, Zhongxiang AU - Li Z AD - Department of Pediatrics, Ganyu District Hospital of Traditional Chinese Medicine, Lianyungang, Jiangsu, China. FAU - Liu, Jiangyan AU - Liu J AD - Department of Pediatrics, The Affiliated Lianyungang Hospital of Xuzhou Medical University (The First People's Hospital of Lianyungang), Lianyungang, Jiangsu, China. FAU - Zhao, Qianye AU - Zhao Q AD - Department of Pediatrics, Lianyungang Maternity and Child Health Hospital, Lianyungang, Jiangsu, China. FAU - Mao, Kangwei AU - Mao K AD - Department of Pediatrics, The Affiliated Lianyungang Hospital of Xuzhou Medical University (The First People's Hospital of Lianyungang), Lianyungang, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260610 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13290602 OTO - NOTNLM OT - PYMS OT - STAMP OT - STRONGkids OT - acute gastroenteritis OT - malnutrition OT - nutritional risk screening OT - pediatric nutrition COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/26 06:38 MHDA- 2026/06/26 06:39 PMCR- 2026/06/10 CRDT- 2026/06/26 04:34 PHST- 2026/03/28 00:00 [received] PHST- 2026/05/05 00:00 [revised] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/26 06:39 [medline] PHST- 2026/06/26 06:38 [pubmed] PHST- 2026/06/26 04:34 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.3389/fnut.2026.1841518 [doi] PST - epublish SO - Front Nutr. 2026 Jun 10;13:1841518. doi: 10.3389/fnut.2026.1841518. eCollection 2026. PMID- 42356915 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 12 DP - 2026 Jun 21 TI - Explainable Machine Learning Using Sensor-Derived Biomechanical Features to Classify Elevated VALR-Related Loading Across Midsole Hardness Conditions in School-Aged Boys. LID - 10.3390/s26123942 [doi] LID - 3942 AB - (1) Background: Changes in midsole hardness may affect lower-limb impact loading during forefoot strike (FFS) running in children, yet the biomechanical basis for discriminating elevated VALR-related loading remains unclear. (2) Methods: Fourteen school-aged boys performed FFS running tests in experimental shoes with four midsole hardness levels (37, 42, 47, and 52 Shore C). Lower-limb kinematics and surface electromyography (sEMG) data were collected during the dominant leg stance phase. After preprocessing, VALR was calculated from 336 valid trials, and 28 stance-phase biomechanical features were extracted, yielding a final machine-learning dataset of 324 trials after excluding incomplete feature data. VALR was used to compare loading changes and define trial-level elevated-loading labels based on the median VALR value. Classification models were evaluated under participant-level GroupKFold validation, and XGBoost was retained for exploratory SHAP analysis. (3) Results: VALR showed an upward trend with increasing hardness, but no statistically supported change point was identified. XGBoost achieved an accuracy of 75.93%, precision of 74.14%, recall of 79.63%, F1-value of 0.768, and pooled out-of-fold AUC of 0.738. SHAP analysis indicated that distal and non-sagittal kinematic features contributed most to model classification. (4) Conclusions: Elevated VALR-related loading during children's FFS running may be characterized by a multi-feature model-based pattern rather than a fixed midsole hardness threshold. FAU - Chen, Yiyao AU - Chen Y AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Gao, Zixiang AU - Gao Z AUID- ORCID: 0000-0002-4345-8201 AD - Faculty of Kinesiology, University of Calgary, Calgary, AB T2N 1N4, Canada. FAU - Li, Fengping AU - Li F AUID- ORCID: 0009-0001-2206-2750 AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Wang, Dongxu AU - Wang D AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Pan, Jianqi AU - Pan J AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Wang, Yucheng AU - Wang Y AUID- ORCID: 0009-0003-1962-4147 AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Chen, Diwei AU - Chen D AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Zhou, Zhanyi AU - Zhou Z AD - Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, 18011 Granada, Spain. FAU - Gao, Lidong AU - Gao L AD - Department of Material Science and Technology, Audi Hungaria Faculty of Automotive Engineering, Szechenyi Istvan University, 9026 Gyor, Hungary. FAU - Chen, Kuiyu AU - Chen K AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Ye, Zhaolong AU - Ye Z AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. FAU - Gu, Yaodong AU - Gu Y AUID- ORCID: 0000-0003-2187-9440 AD - Faculty of Sports Science, Ningbo University, Ningbo 315211, China. AD - Department of Kinesiology, Hungarian University of Sports Science, 1123 Budapest, Hungary. LA - eng PT - Journal Article DEP - 20260621 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - Male MH - Biomechanical Phenomena/physiology MH - Electromyography MH - Hardness/physiology MH - *Machine Learning MH - *Running/physiology MH - Child MH - Shoes MH - Boosting Machine Learning Algorithms PMC - PMC13307089 OTO - NOTNLM OT - SHAP OT - XGBoost OT - elevated VALR-related loading OT - forefoot strike OT - midsole hardness OT - school-aged boys COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/06/26 13:10 MHDA- 2026/06/27 07:40 PMCR- 2026/06/21 CRDT- 2026/06/26 01:19 PHST- 2026/05/06 00:00 [received] PHST- 2026/06/15 00:00 [revised] PHST- 2026/06/18 00:00 [accepted] PHST- 2026/06/27 07:40 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:19 [entrez] PHST- 2026/06/21 00:00 [pmc-release] AID - s26123942 [pii] AID - sensors-26-03942 [pii] AID - 10.3390/s26123942 [doi] PST - epublish SO - Sensors (Basel). 2026 Jun 21;26(12):3942. doi: 10.3390/s26123942. PMID- 42356815 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 12 DP - 2026 Jun 17 TI - Prediction of Nocturnal Hypoglycemia Following Exercise in Type 1 Diabetes Using Temporally Structured CGM-Derived Digital Biomarkers. LID - 10.3390/s26123842 [doi] LID - 3842 AB - Nocturnal hypoglycemia (NH) following exercise represents a critical challenge in the management of type 1 diabetes (T1D), particularly in pediatric populations, where its occurrence is associated with severe adverse outcomes and increased caregiver burden. This study aimed to identify an interpretable early signature based on CGM-derived digital biomarkers of post-exercise NH risk in children and adolescents with T1D. CGM data from 49 pediatric subjects (DirecNet cohort) were used to extract several CGM metrics across two temporal configurations: (i) Exercise + Cumulative, where features were computed over the exercise window and over an extended window spanning from exercise onset through recovery (16:00-17:00 and 16:00-22:00); and (ii) Exercise + Post-exercise, where features were computed separately over two non-overlapping intervals, capturing the exercise phase and the subsequent recovery phase (16:00-17:00 and 17:00-22:00). A Random Forest classifier was trained within a Leave-One-Out Cross Validation framework, incorporating variance inflation factor (VIF)-based multicollinearity filtering, minimum redundancy-maximum relevance (mRMR) feature selection, and SMOTE-based class balancing. The Exercise + Post-exercise configuration achieved superior performance: balanced accuracy (BA) = 76.9%, F1-score = 0.71, Area Under Receiver Operating Characteristic Curve (ROC-AUC) = 0.75, outperforming the Exercise + Cumulative configuration; this result was achieved using only five features: CONGA-15_EX (short-term glucose variability during exercise) emerged as the most robust predictor, alongside below_54 and above_250 (time spent in hypoglycemic and hyperglycemic ranges), MAG (mean absolute glucose change), and GRADE_hypo (hypoglycemia risk score). The generalizability of the temporal framework was further supported by independent validation on the OhioT1DM free-living cohort, where the Exercise + Post-exercise configuration (BA = 76.3%, ROC-AUC = 0.804) again outperformed the cumulative approach. These results suggest that a small set of interpretable CGM-derived features, extracted from the exercise and recovery windows, can effectively discriminate pediatric T1D subjects at risk of NH, supporting the development of lightweight CGM-only decision support tools for safer exercise management. FAU - Piersanti, Agnese AU - Piersanti A AD - Department of Information Engineering, Universita Politecnica delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy. FAU - Manes, Gaia Maria AU - Manes GM AD - Department of Information Engineering, Universita Politecnica delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy. FAU - Del Giudice, Libera Lucia AU - Del Giudice LL AUID- ORCID: 0009-0008-0723-1289 AD - Department of Information Engineering, Universita Politecnica delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy. FAU - Burattini, Laura AU - Burattini L AD - Department of Information Engineering, Universita Politecnica delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy. FAU - Gobl, Christian AU - Gobl C AD - Department of Obstetrics and Gynaecology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria. FAU - Tura, Andrea AU - Tura A AUID- ORCID: 0000-0003-3466-5900 AD - CNR Institute of Neuroscience, Corso Stati Uniti 4, 35127 Padova, Italy. FAU - Morettini, Micaela AU - Morettini M AUID- ORCID: 0000-0002-8327-8379 AD - Department of Information Engineering, Universita Politecnica delle Marche, Via Brecce Bianche 12, 60131 Ancona, Italy. LA - eng PT - Journal Article DEP - 20260617 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/blood MH - *Hypoglycemia/diagnosis/blood MH - Continuous Glucose Monitoring MH - *Biomarkers/blood MH - *Exercise/physiology MH - Adolescent MH - Child MH - Female MH - Male MH - Blood Glucose/analysis PMC - PMC13307307 OTO - NOTNLM OT - SMOTE OT - continuous glucose monitoring OT - exercise OT - feature engineering OT - machine learning OT - nocturnal hypoglycemia OT - type 1 diabetes COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 13:10 MHDA- 2026/06/27 07:40 PMCR- 2026/06/17 CRDT- 2026/06/26 01:19 PHST- 2026/05/07 00:00 [received] PHST- 2026/06/09 00:00 [revised] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/06/27 07:40 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:19 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - s26123842 [pii] AID - sensors-26-03842 [pii] AID - 10.3390/s26123842 [doi] PST - epublish SO - Sensors (Basel). 2026 Jun 17;26(12):3842. doi: 10.3390/s26123842. PMID- 42356382 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 19 TI - Assessing the Nutritional and Neurodevelopmental Status in Children Attending Preschools in a Neighborhood in Bogota, Colombia. LID - 10.3390/nu18121996 [doi] LID - 1996 AB - Background: Early childhood nutrition is strongly associated with neurodevelopmental outcomes, particularly in socially vulnerable settings. Limited evidence is available describing the relationship between nutritional status, food security, and neurodevelopment among preschool children in low-income urban areas of Colombia. This study aimed to evaluate nutritional status, household food insecurity, and neurodevelopmental outcomes in children attending early childhood centers in El Codito, Bogota, and to explore the association between anthropometric indicators and neurodevelopmental performance. Methods: A cross-sectional study was conducted in children enrolled in community childcare centers. Nutritional status was assessed using anthropometric indicators according to World Health Organization growth standards, including weight for age, height for age, and body mass index for age. Neurodevelopment was evaluated using the Escala Abreviada de Desarrollo (EAD). Household food insecurity was measured through a validated questionnaire. Descriptive statistics were performed, and associations between variables were analyzed using correlation tests and group comparisons according to data distribution. Results: Most participants presented adequate nutritional status; however, a proportion of children showed risk of stunting or excess weight. Neurodevelopmental scores were generally within expected ranges, although variability was observed across developmental domains. Significant associations were identified between certain anthropometric indicators and neurodevelopmental outcomes. Moderate to severe household food insecurity was identified in 21.4% of participating households. Conclusions: Nutritional status and household food insecurity represent important contextual factors for child health in vulnerable urban populations. These findings highlight the importance of integrated nutritional and developmental monitoring strategies within early childhood programs. Further longitudinal studies are required to clarify causal pathways and to guide targeted public health interventions in similar contexts. FAU - Aguilera-Arino, Laura Sofia AU - Aguilera-Arino LS AD - Neuroscience Research Group (Neuros), Centro de Neurociencia-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Talero-Gutierrez, Claudia AU - Talero-Gutierrez C AUID- ORCID: 0000-0003-1601-5015 AD - Neuroscience Research Group (Neuros), Centro de Neurociencia-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Velez-Van-Merbeeke, Alberto AU - Velez-Van-Merbeeke A AUID- ORCID: 0000-0002-8889-4170 AD - Neuroscience Research Group (Neuros), Centro de Neurociencia-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Pedraza-Lopez, Natalia AU - Pedraza-Lopez N AUID- ORCID: 0009-0001-3491-5212 AD - Clinical Research Group-Epidemiological Studies Line, School of Medicine and Health Sciences, Universidad del Rosario, Quinta de Mutis Campus, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Patino-Rattiva, Maria AU - Patino-Rattiva M AD - Undergraduate Neuroscience Research Group (Semineuros), Center of Neuroscience-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Pastrana-Bustamante, Isabella AU - Pastrana-Bustamante I AD - Undergraduate Neuroscience Research Group (Semineuros), Center of Neuroscience-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Ospina-Arias, Juan Andres AU - Ospina-Arias JA AD - Undergraduate Neuroscience Research Group (Semineuros), Center of Neuroscience-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Quijano-Zauner, Mariana AU - Quijano-Zauner M AD - Undergraduate Neuroscience Research Group (Semineuros), Center of Neuroscience-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Velasquez, Maria Jose AU - Velasquez MJ AD - Undergraduate Neuroscience Research Group (Semineuros), Center of Neuroscience-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Carvajal-Rincon, Sara Sofia AU - Carvajal-Rincon SS AUID- ORCID: 0009-0001-7394-5588 AD - Undergraduate Neuroscience Research Group (Semineuros), Center of Neuroscience-Neurovitae, School of Medicine and Health Sciences, Universidad del Rosario, Carrera 24 #63c-69, Bogota 111221, Colombia. FAU - Pinzon-Rondon, Angela Maria AU - Pinzon-Rondon AM AD - Clinical Research Group-Epidemiological Studies Line, School of Medicine and Health Sciences, Universidad del Rosario, Quinta de Mutis Campus, Carrera 24 #63c-69, Bogota 111221, Colombia. LA - eng PT - Journal Article DEP - 20260619 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Colombia/epidemiology MH - *Nutritional Status MH - Child, Preschool MH - Cross-Sectional Studies MH - Female MH - Male MH - Neurodevelopment MH - *Child Development MH - Food Insecurity MH - Anthropometry MH - Urban Population MH - Poverty PMC - PMC13305189 OTO - NOTNLM OT - anthropometry OT - child development OT - malnutrition OT - neurodevelopmental disorders OT - nutritional status COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 06:40 MHDA- 2026/06/27 07:10 PMCR- 2026/06/19 CRDT- 2026/06/26 01:17 PHST- 2026/05/12 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 06:40 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - nu18121996 [pii] AID - nutrients-18-01996 [pii] AID - 10.3390/nu18121996 [doi] PST - epublish SO - Nutrients. 2026 Jun 19;18(12):1996. doi: 10.3390/nu18121996. PMID- 42356370 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 19 TI - Eating Disorder Risk Among Italian University Students: A Cross-Sectional Screening Study Using BMI, EAT-26, and EDE-Q 6.0. LID - 10.3390/nu18121984 [doi] LID - 1984 AB - Background/Objectives: Eating disorders (EDs) are among the most severe psychiatric conditions affecting young people, with increasing prevalence in the post-pandemic period. This study assessed the prevalence of ED risk and dysfunctional eating behaviors among Italian university students, a population poorly characterized with respect to ED risk, and examined associations with key socio-demographic and anthropometric variables. Methods: A cross-sectional online screening study was conducted between August 2023 and February 2026 with 401 Italian university students (306 women and 95 men). Participants completed the validated Italian versions of the Eating Attitudes Test-26 (EAT-26) and the Eating Disorder Examination Questionnaire 6.0 (EDE-Q 6.0), alongside self-reported anthropometric data. Multiple linear regression analyses were performed to identify predictors of ED risk scores. Results: A total of 37.9% of participants had BMI outside the normal range (19.7% underweight; 18.2% overweight or obese). EAT-26 scores exceeded the clinical cut-off in 28.4% of participants (women: 35.6%; men: 5.3%). EDE-Q 6.0 global scores exceeded the clinical cut-off in 21.0% (women: 25.8%; men: 5.3%). Only 45.4% showed no anthropometric or questionnaire-based screening risk indicators (i.e., scores above the clinical cut-off on the EAT-26 or EDE-Q 6.0). BMI was negatively associated with EAT-26 scores in the total sample and in women, while a positive association between BMI and EDE-Q 6.0 scores was observed in men. Conclusions: A substantial proportion of Italian university students, particularly women, presented screening-based indicators of ED risk. The combined use of anthropometric and questionnaire-based screening tools provides a more comprehensive risk assessment than either measure alone, highlighting the need for multidimensional screening programs. FAU - Gosti, Valeria AU - Gosti V AUID- ORCID: 0009-0000-6071-2497 AD - Department of Human Sciences, Universita degli Studi Guglielmo Marconi, 00193 Rome, Italy. AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. FAU - Coletta, Antonella AU - Coletta A AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. FAU - Vinci, Andrea Carolina AU - Vinci AC AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. FAU - Massaro, Francesca AU - Massaro F AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. FAU - Foti, Francesca AU - Foti F AD - Department of Educational Sciences, University of Catania, 95124 Catania, Italy. FAU - Koch, Giacomo AU - Koch G AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. AD - Department of Neuroscience and Rehabilitation, University of Ferrara, 44121 Ferrara, Italy. FAU - Gelfo, Francesca AU - Gelfo F AUID- ORCID: 0000-0002-3935-2164 AD - Department of Human Sciences, Universita degli Studi Guglielmo Marconi, 00193 Rome, Italy. AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. FAU - Betti, Viviana AU - Betti V AUID- ORCID: 0000-0003-3429-2104 AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. AD - Department of Psychology, Sapienza University of Rome, 00185 Rome, Italy. FAU - Petrosini, Laura AU - Petrosini L AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. FAU - Picazio, Silvia AU - Picazio S AUID- ORCID: 0000-0002-1784-7537 AD - Department of Human Sciences, Universita degli Studi Guglielmo Marconi, 00193 Rome, Italy. AD - Santa Lucia Foundation (Scientific Research and Treatment Institute), 00179 Rome, Italy. LA - eng GR - GR-2019-2369640/Ministry of Health/ PT - Journal Article DEP - 20260619 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Male MH - Cross-Sectional Studies MH - Italy/epidemiology MH - *Feeding and Eating Disorders/epidemiology/diagnosis MH - *Students/psychology/statistics & numerical data MH - *Body Mass Index MH - Young Adult MH - Universities MH - Adult MH - Surveys and Questionnaires MH - Risk Factors MH - Prevalence MH - Adolescent MH - Feeding Behavior/psychology PMC - PMC13304807 OTO - NOTNLM OT - EAT-26 OT - EDE-Q 6.0 OT - body mass index OT - eating disorders OT - gender differences OT - university students COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/19 CRDT- 2026/06/26 01:17 PHST- 2026/05/11 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - nu18121984 [pii] AID - nutrients-18-01984 [pii] AID - 10.3390/nu18121984 [doi] PST - epublish SO - Nutrients. 2026 Jun 19;18(12):1984. doi: 10.3390/nu18121984. PMID- 42356337 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 17 TI - Ultra-Processed Food Consumption Is Independently Associated with Higher HbA1c and Poor Glycemic Control in Adults with Type 2 Diabetes. LID - 10.3390/nu18121951 [doi] LID - 1951 AB - Background/Objectives: Ultra-processed food (UPF) consumption has been linked to type 2 diabetes mellitus (T2DM) incidence, but its association with glycemic control in individuals already living with T2DM remains less well characterized. We evaluated the relationship between UPF consumption, assessed with the Turkish version of the short Screening Questionnaire of Highly Processed Food Consumption (sQ-HPF), and HbA1c and poor glycemic control in adults with T2DM. Methods: In this single-centre, cross-sectional observational study, 425 adults aged 18-65 years with T2DM of at least 6 months' duration were consecutively recruited at a tertiary general internal medicine outpatient clinic. UPF consumption was assessed with the Turkish sQ-HPF (range 0-11; scores >/= 6 = high UPF consumption). HbA1c was the primary outcome (continuous and dichotomized at 7.0%). Multiple linear and binary logistic regression analyses were performed with hierarchical adjustment for age, sex, body mass index (BMI), diabetes duration, and insulin-based treatment. Results: Total UPF score was positively correlated with HbA1c (r = 0.423, p < 0.001). In the fully adjusted linear model, each one-point increase in total UPF score was associated with a 0.418% higher HbA1c (95% CI: 0.333-0.503; beta = 0.413; p < 0.001), explaining 28.9% of HbA1c variance. In the fully adjusted logistic model, each one-point increase in total UPF score was associated with 25.0% higher odds of poor glycemic control (OR = 1.250, 95% CI: 1.110-1.408, p < 0.001). Insulin-based treatment and male sex were also independent predictors. UPF score was not significantly associated with lipid parameters or C-reactive protein. Conclusions: Higher UPF consumption, captured by a brief validated screener, was independently associated with poorer glycemic control in Turkish adults with T2DM. Brief UPF screening may help identify patients who would benefit from targeted nutritional intervention. FAU - Otay Lule, Nezihe AU - Otay Lule N AUID- ORCID: 0000-0003-3664-6383 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gaziantep University, 27310 Gaziantep, Turkiye. FAU - Sahin, Serpil AU - Sahin S AUID- ORCID: 0009-0009-7541-202X AD - Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27310 Gaziantep, Turkiye. FAU - Lule, Kemal Ozan AU - Lule KO AUID- ORCID: 0000-0003-3582-9663 AD - Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27310 Gaziantep, Turkiye. FAU - Yildiz, Hamit AU - Yildiz H AUID- ORCID: 0000-0001-7858-5123 AD - Department of Internal Medicine, Faculty of Medicine, Gaziantep University, 27310 Gaziantep, Turkiye. LA - eng PT - Journal Article PT - Observational Study DEP - 20260617 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Glycated Hemoglobin) RN - 0 (Blood Glucose) RN - 0 (hemoglobin A1c protein, human) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/blood MH - Middle Aged MH - Male MH - Female MH - *Glycated Hemoglobin/metabolism/analysis MH - Adult MH - Cross-Sectional Studies MH - *Glycemic Control MH - Food, Processed MH - Aged MH - *Blood Glucose/metabolism MH - *Fast Foods/adverse effects MH - Young Adult MH - Adolescent MH - Turkey PMC - PMC13304910 OTO - NOTNLM OT - HbA1c OT - cardiometabolic risk OT - glycemic control OT - sQ-HPF OT - type 2 diabetes mellitus OT - ultra-processed food COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/17 CRDT- 2026/06/26 01:17 PHST- 2026/05/27 00:00 [received] PHST- 2026/06/11 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - nu18121951 [pii] AID - nutrients-18-01951 [pii] AID - 10.3390/nu18121951 [doi] PST - epublish SO - Nutrients. 2026 Jun 17;18(12):1951. doi: 10.3390/nu18121951. PMID- 42356324 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 15 TI - Green Tea Consumption and Risk of All-Cause Mortality: Findings from a Prospective Cohort Study. LID - 10.3390/nu18121937 [doi] LID - 1937 AB - BACKGROUND/OBJECTIVES: There has been a growing concern about excessive caffeine consumption among heavy green tea drinkers on health outcomes, such as cardiovascular diseases or cancer. We evaluated the association between green tea consumption and risk of all-cause mortality in Vietnam. METHODS: We used data from the Hanoi Prospective Cohort Study, an ongoing study comprising 42,146 participants aged 10 or older in Northern Vietnam who have been followed up between 2007 and 2019. Green tea intake was derived from a validated semi-quantitative food frequency questionnaire. We performed a Cox proportional hazard regression model to calculate the hazard ratio (HR) and respective 95% confidence intervals (95% CIs) for the association between green tea consumption and risk of all-cause mortality, adjusted for potential confounding factor. RESULTS: After a median follow-up of 11 years (range: 0.13-11.64 years), we identified 2494 deaths. Overall, there was an inverse association between green tea intake and risk of all-cause mortality (HR(perSDincrement) = 0.93; 95% CI, 0.89-0.97, P(trend) < 0.001). This pattern was more pronounced in males (HR(perSDincrement) = 0.93; 95% CI, 0.89-0.97, P(trend) < 0.001) but not in females (HR(perSDincrement) = 0.94; 95% CI, 0.86-1.02, P(trend) = 0.12; P(heterogeneity) = 0.81). In stratified analysis, the inverse association pattern was seen in both younger and old age groups, in individuals with BMI < 23 kg/m(2), in both ever and never smokers, among ever alcohol drinkers and never coffee drinkers, and in individuals with and without history of type 2 diabetes (P(heterogeneity) = 0.31). CONCLUSIONS: Findings from the current study, the first prospective cohort study in Vietnam, suggest a protective effect of green tea consumption on risk of all-cause mortality. Further studies are warranted to validate our findings in similar population and settings. FAU - Le, Ngoan Tran AU - Le NT AUID- ORCID: 0000-0001-7862-492X AD - Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam. AD - Department of Clinical Research, Vinmec Healthcare System, Hanoi 100000, Vietnam. FAU - Pham, Yen Thi-Hai AU - Pham YT AD - University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA 15232, USA. AD - Dr. Mary and Ron Neal Cancer Center, Houston Methodist Research Institute, Houston, TX 77030, USA. FAU - Nguyen, Hieu Lan AU - Nguyen HL AD - Department of Cardiovascular Diseases, Hanoi Medical University, Hanoi 100000, Vietnam. FAU - Le, Linh Thuy AU - Le LT AD - Laboratory of Embryology and Genetics of Human Malformation, Imagine Institute, INSERM UMR (National Institute of Health and Medical Research, Mixed Research Unit), 75015 Paris, France. FAU - Nguyen, Ninh Thi AU - Nguyen NT AUID- ORCID: 0009-0008-6658-8675 AD - Department of Occupational Health, Institute for Preventive Medicine and Public Health, Hanoi Medical University, Hanoi 100000, Vietnam. FAU - Vu, Thao Thu Thi AU - Vu TTT AUID- ORCID: 0009-0007-0413-3707 AD - General Daycare Inpatient Department, Hanoi Oncology Hospital, Hanoi 100000, Vietnam. FAU - Koriyama, Chihaya AU - Koriyama C AUID- ORCID: 0000-0003-3676-8866 AD - Department of Epidemiology and Preventive Medicine, Graduate School of Medical and Dental Science, Kagoshima University, Kagoshima 890-8544, Japan. FAU - Nguyen, Ha AU - Nguyen H AD - Department of Computer Science, Wayne State University, Detroit, MI 48202, USA. FAU - Nguyen, Tin C AU - Nguyen TC AUID- ORCID: 0000-0001-8001-9470 AD - Department of Industrial and Systems Engineering, Wayne State University, Detroit, MI 48202, USA. AD - Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA. FAU - Vo, Nam S AU - Vo NS AD - VinUni Big Data Research Institute, VinUniversity, Hanoi 100000, Vietnam. FAU - Wu, Lang AU - Wu L AD - LSU-LCMC Health Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA. FAU - Cullen, Jennifer AU - Cullen J AD - Dr. Mary and Ron Neal Cancer Center, Houston Methodist Research Institute, Houston, TX 77030, USA. AD - Department of Population and Quantitative Health Sciences, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA. FAU - Luu, Hung N AU - Luu HN AUID- ORCID: 0000-0002-2172-1849 AD - University of Pittsburgh Medical Center Hillman Cancer Center, Pittsburgh, PA 15232, USA. AD - Dr. Mary and Ron Neal Cancer Center, Houston Methodist Research Institute, Houston, TX 77030, USA. AD - Department of Medicine, Weill Cornell Medicine, Cornell University, New York, NY 10065, USA. LA - eng PT - Journal Article DEP - 20260615 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Tea) SB - IM MH - Humans MH - *Tea MH - Male MH - Prospective Studies MH - Female MH - Middle Aged MH - Vietnam/epidemiology MH - Risk Factors MH - Adult MH - Proportional Hazards Models MH - *Mortality MH - Adolescent MH - Young Adult MH - Child MH - Cause of Death MH - Aged PMC - PMC13304542 OTO - NOTNLM OT - Vietnam OT - all-cause mortality OT - green tea OT - prospective cohort study OT - risk COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 10:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/15 CRDT- 2026/06/26 01:17 PHST- 2026/03/31 00:00 [received] PHST- 2026/06/07 00:00 [revised] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 10:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - nu18121937 [pii] AID - nutrients-18-01937 [pii] AID - 10.3390/nu18121937 [doi] PST - epublish SO - Nutrients. 2026 Jun 15;18(12):1937. doi: 10.3390/nu18121937. PMID- 42356309 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 13 TI - Completion Rates of Food Frequency Questionnaires and Food Records in People with Chronic Conditions: Systematic Review and Meta-Analysis. LID - 10.3390/nu18121922 [doi] LID - 1922 AB - Background/Objectives: Dietary assessment tools are essential for quantifying food and nutrient intake, characterising dietary patterns, and informing nutrition research. Food Frequency Questionnaires (FFQs) and Food Records (FRs) are widely implemented in observational studies, but completion rates vary, which may compromise data quality, introduce bias, and limit the interpretation of findings. This review is intended to synthesise evidence from observational studies on completion rates of these tools in populations with chronic conditions. Methods: A systematic search of Medline, PubMed, Scopus, and Google Scholar was completed. Eligible studies were observational studies using an FFQ or FR published from January 2015 to May 2025 in people with a chronic condition. Methodological quality was evaluated using the Hoy Risk of Bias tool for observational studies of prevalence. Subgroup meta-analyses estimated pooled mean completion proportions with 95% confidence intervals, and heterogeneity was assessed using the I(2) statistic. This study was registered with the International Prospective Register of Systematic Reviews and reported according to PRISMA guidelines. Results: Of the 8921 records screened, 88 studies (n = 84,579 participants) met inclusion criteria. The combined FFQ and food record mean pooled completion rate was 79.1% (95% Confidence Interval (CI): 74.37-83.43%). However, substantial heterogeneity was observed, indicating considerable variability across studies. Subgroup analyses highlighted important differences by tool type, format, age group, and disease category. FFQs demonstrated higher completion rates (80.6%) than FRs (74.3%). Electronic formats had higher completion rates than paper formats. Completion rates were higher in adults than in pediatric cohorts, and varied by chronic condition type, with kidney disease associated with the highest completion rates. Conclusions: These findings highlight the importance of considering tailored dietary data collection strategies, particularly for paediatric and medically complex populations, and provide direction for enhancing the feasibility of dietary assessment collection in future research. FAU - Kyei, Amanda AU - Kyei A AD - School of Medical, Indigenous and Health Sciences, University of Wollongong, Wollongong, NSW 2500, Australia. FAU - Miglioretto, Chiara AU - Miglioretto C AUID- ORCID: 0009-0005-2013-3155 AD - School of Medical, Indigenous and Health Sciences, University of Wollongong, Wollongong, NSW 2500, Australia. AD - Health Innovations, University of Wollongong, Wollongong, NSW 2500, Australia. FAU - Perez, Geraldine AU - Perez G AD - School of Medical, Indigenous and Health Sciences, University of Wollongong, Wollongong, NSW 2500, Australia. AD - Health Innovations, University of Wollongong, Wollongong, NSW 2500, Australia. FAU - Lambert, Kelly AU - Lambert K AUID- ORCID: 0000-0001-5935-7328 AD - School of Medical, Indigenous and Health Sciences, University of Wollongong, Wollongong, NSW 2500, Australia. AD - Health Innovations, University of Wollongong, Wollongong, NSW 2500, Australia. AD - Kidney Lifestyle Research Group, University of Wollongong, Wollongong, NSW 2500, Australia. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260613 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Chronic Disease MH - *Diet Records MH - *Nutrition Assessment MH - *Diet Surveys MH - Surveys and Questionnaires MH - Observational Studies as Topic MH - Female MH - Feeding Behavior MH - Adult MH - Diet MH - Male MH - Middle Aged PMC - PMC13306072 OTO - NOTNLM OT - chronic disease OT - dietary assessment OT - food frequency questionnaire OT - food record OT - meta-analysis OT - observational study OT - systematic review COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:40 PMCR- 2026/06/13 CRDT- 2026/06/26 01:17 PHST- 2026/05/03 00:00 [received] PHST- 2026/06/10 00:00 [revised] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/06/27 07:40 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - nu18121922 [pii] AID - nutrients-18-01922 [pii] AID - 10.3390/nu18121922 [doi] PST - epublish SO - Nutrients. 2026 Jun 13;18(12):1922. doi: 10.3390/nu18121922. PMID- 42356286 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 11 TI - Socio-Demographic and Anthropometric Findings of Women Caregivers in Qwa-Qwa, Free State Province, South Africa. LID - 10.3390/nu18121898 [doi] LID - 1898 AB - Background: Women remain the primary caregivers globally, especially in rural, low-resource settings plagued by poverty, unemployment, low education and poor infrastructure. These factors limit caregiving capacity, heighten vulnerability and increase the risk of food insecurity in female-headed households. Objective: To establish a baseline profile of caregivers of primary school children. Methods: Phase 1 (baseline) of the study was conducted using a quantitative, exploratory cross-sectional survey design among 75 female caregivers of children aged 7-13 years in Qwa-Qwa, Free State Province. Participants were recruited using convenience sampling. Data were collected with a structured, pre-validated questionnaire on socio-demographics, alongside anthropometric measurements. Data were analysed using descriptive statistics. Results: Most participants were unemployed (73.3%) and had low educational attainment, with 86.7% having completed primary school or less. A substantial proportion of households (80.0%) reported a monthly income below R1000. Food insecurity was common, with 69.3% of caregivers reporting experiences of food shortages. Household infrastructure was limited, particularly in refuse removal services (96.0% without access). Despite these socio-economic constraints, a high prevalence of overweight and obesity (72.5%) was observed amongst the participants. Conclusions: Caregivers experience severe, overlapping socio-economic and environmental vulnerabilities alongside a high prevalence of overweight and obesity. The study highlights the need for multi-sectoral interventions focused on poverty reduction, rural infrastructure development, improved service delivery, women's empowerment and strengthened livelihood opportunities to improve household nutrition and resilience. FAU - Mangwane, Queen E M AU - Mangwane QEM AUID- ORCID: 0000-0002-3863-4135 AD - Department of Hospitality Management, Faculty of Management Sciences, Tshwane University of Technology, Pretoria 0001, South Africa. FAU - Egal, Abdulkadir AU - Egal A AUID- ORCID: 0000-0003-0303-6319 AD - Department of Tourism & Integrated Communication, Faculty of Human Sciences, Vaal University of Technology, Vanderbijlpark 1900, South Africa. FAU - Oosthuizen, Delia AU - Oosthuizen D AUID- ORCID: 0000-0001-7570-270X AD - Department of Tourism & Integrated Communication, Faculty of Human Sciences, Vaal University of Technology, Vanderbijlpark 1900, South Africa. LA - eng PT - Journal Article DEP - 20260611 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - South Africa/epidemiology MH - *Caregivers/statistics & numerical data MH - Cross-Sectional Studies MH - Child MH - Adolescent MH - Food Insecurity MH - Anthropometry MH - Adult MH - Socioeconomic Factors MH - Poverty MH - Overweight/epidemiology MH - Middle Aged MH - Food Supply MH - Obesity/epidemiology MH - Rural Population MH - Prevalence MH - Family Characteristics MH - Surveys and Questionnaires MH - Sociodemographic Factors PMC - PMC13304777 OTO - NOTNLM OT - anthropometric status OT - malnutrition OT - socioeconomic vulnerability OT - women caregivers COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/11 CRDT- 2026/06/26 01:17 PHST- 2026/04/20 00:00 [received] PHST- 2026/06/02 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - nu18121898 [pii] AID - nutrients-18-01898 [pii] AID - 10.3390/nu18121898 [doi] PST - epublish SO - Nutrients. 2026 Jun 11;18(12):1898. doi: 10.3390/nu18121898. PMID- 42356284 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 11 TI - Sex-Stratified Correlates of Pulmonary Function in Mexican Children and Adolescents (6-17 Years) with Asthma: An Exploratory Analysis of HDL Cholesterol, BMI, and Pubertal Stage. LID - 10.3390/nu18121885 [doi] LID - 1885 AB - Background/Objectives: Pubertal maturation encompasses hormonal, somatic, and metabolic alterations that may influence pulmonary function in children with asthma. We evaluated the correlates of pulmonary function in pediatric asthma using sex-stratified analyses of pubertal stage, BMI z-score, asthma control (ACQ-6), and HDL cholesterol levels on FEV1, FVC, and the FEV1/FVC ratio (% predicted, NHANES III). Methods: A cross-sectional study was conducted with 118 children and adolescents with asthma (74 males and 44 females). The Tanner stages were categorized as pre-/early (I-II), mid (III), and late (IV). No participant had reached Tanner stage V at recruitment, and the reference category was composed predominantly of Tanner II participants; therefore, the pubertal contrast reflected early- versus mid-/late-pubertal physiology rather than a strictly prepubertal-versus-pubertal comparison. We performed hierarchical linear regression with bias-corrected and accelerated bootstrap inference (5000 replicates) for each sex and for all participants combined, complemented by a formal sex x predictor interaction test. Results: Mid- and late puberty were independently associated with reduced FEV1% and FVC% (beta -0.25 to -0.31), without affecting the FEV1/FVC ratio. Sex-stratified analyses were exploratory and identified apparently divergent predictor sets by sex: in males, the pubertal stage was significant in FEV1% and FVC% (beta -0.30 to -0.42), whereas the BMI z-score diminished the FEV1/FVC ratio (beta = -0.274). In females, FEV1% was associated with HDL-c (beta = 0.463), BMI z-score (beta = 0.429), and ACQ-6 score (beta = -0.306); the female FEV1/FVC% model showed a substantial apparent effect (Cohen's f(2) = 0.508), with ACQ-6 score and HDL-c as primary associated variables. The formal sex x predictor interaction test in the combined sample, however, did not reach statistical significance (DeltaR(2) = 0.037; p = 0.178), indicating that the sex-differential patterns observed in the stratified models were not confirmed as effect modifications. Conclusions: Sex-stratified exploratory analyses in this pediatric asthma cohort identified apparently divergent patterns of associations in males and females; however, the formal interaction test was not statistically significant, indicating that these stratified differences were not confirmed and require validation in adequately powered prospective cohorts. These findings identify HDL-c, body composition, and symptom control as candidate correlates of pulmonary function, with potential sex-related differences warranting further investigation. FAU - Reyes-Noriega, Nayely AU - Reyes-Noriega N AUID- ORCID: 0000-0002-1701-7517 AD - Laboratorio de Investigacion en Alergia e Inmunologia, Hospital Infantil de Mexico Federico Gomez, Dr Marquez 162, Cuauhtemoc, Mexico City 06720, Mexico. FAU - Leija-Martinez, Jose J AU - Leija-Martinez JJ AUID- ORCID: 0000-0002-7178-1786 AD - Hospital Regional de Alta Especialidad "Dr. Ignacio Morones Prieto", IMSS-Bienestar, Av. Venustiano Carranza No. 2395, San Luis Potosi 78290, Mexico. FAU - Sanchez-Munoz, Fausto AU - Sanchez-Munoz F AUID- ORCID: 0000-0001-6556-1632 AD - Departamento de Fisiologia, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City 14080, Mexico. FAU - Hernandez-Diazcouder, Adrian AU - Hernandez-Diazcouder A AUID- ORCID: 0000-0001-6569-2851 AD - Unidad de Investigacion Medica en Bioquimica, Hospital de Especialidades, Centro Medico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City 06720, Mexico. FAU - Alonso, Claudia Tavera AU - Alonso CT AD - Laboratorio Central, Instituto Nacional de Cardiologia Ignacio Chavez, Mexico City 14080, Mexico. FAU - Villafana, Santiago AU - Villafana S AUID- ORCID: 0000-0002-8660-7393 AD - Laboratorio de Terapia Genica Experimental, Escuela Superior de Medicina, Instituto Politecnico Nacional, Mexico City 11340, Mexico. FAU - Diaz, Dario Jorge Mario Molina AU - Diaz DJMM AD - Departamento de Endocrinologia, Hospital Infantil de Mexico Federico Gomez, Dr Marquez 162, Cuauhtemoc, Mexico City 06720, Mexico. FAU - Del-Rio-Navarro, Blanca E AU - Del-Rio-Navarro BE AUID- ORCID: 0000-0001-6441-8869 AD - Laboratorio de Investigacion en Alergia e Inmunologia, Hospital Infantil de Mexico Federico Gomez, Dr Marquez 162, Cuauhtemoc, Mexico City 06720, Mexico. FAU - Huang, Fengyang AU - Huang F AUID- ORCID: 0000-0002-6503-694X AD - Laboratorio de Investigacion en Obesidad y Asma, Hospital Infantil de Mexico Federico Gomez, Mexico City 06720, Mexico. LA - eng GR - HIM/2021/023.SSa. 1748/Federal Government of Mexico/ GR - HIM/2022/044.SSa. 1809/Federal Government of Mexico/ GR - HIM/2023/015 SSa. 1857/Federal Government of Mexico/ GR - HIM/2024/045 SSa. 1943/Federal Government of Mexico/ PT - Journal Article DEP - 20260611 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Cholesterol, HDL) SB - IM MH - Humans MH - Child MH - Adolescent MH - Female MH - Male MH - *Asthma/physiopathology/blood MH - *Cholesterol, HDL/blood MH - Cross-Sectional Studies MH - *Body Mass Index MH - *Puberty/physiology MH - Mexico MH - Sex Factors MH - *Lung/physiopathology MH - Respiratory Function Tests MH - Forced Expiratory Volume MH - Vital Capacity PMC - PMC13305537 OTO - NOTNLM OT - FEV1 OT - FVC OT - HDL cholesterol OT - adolescents OT - asthma OT - asthma control OT - children OT - pubertal development OT - sex differences COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/11 CRDT- 2026/06/26 01:17 PHST- 2026/05/08 00:00 [received] PHST- 2026/06/02 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - nu18121885 [pii] AID - nutrients-18-01885 [pii] AID - 10.3390/nu18121885 [doi] PST - epublish SO - Nutrients. 2026 Jun 11;18(12):1885. doi: 10.3390/nu18121885. PMID- 42356247 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 9 TI - Food Industry By-Products as Natural Preservatives: Supporting Adolescent Food Literacy and Critical Food Choices. LID - 10.3390/nu18121859 [doi] LID - 1859 AB - This review aims to critically examine food industry by-products as potential sources of natural preservatives and to discuss how this evidence can be translated into adolescent food literacy, label interpretation, and critical food choices. Adolescents are increasingly exposed to food labels and claims about "natural," "clean-label," "upcycled," "sustainable," and "circular" foods, which may not always be transparent or supported by sufficient evidence regarding their safety, efficacy, sensory quality, consumer acceptance, or environmental benefit. Therefore, they need more than nutritional information; they need to interpret labels, question sustainability claims, and understand how food innovations are produced, tested, communicated, and regulated. Food by-products such as fruit and vegetable pomaces, peels, seeds, skins, olive and wine residues, cereal by-products, coffee silverskin, and cocoa residues are promising resources for clean-label preservation and circular food systems because they may contain phenolics, flavonoids, carotenoids, anthocyanins, essential oils, pectin, dietary fibers, and other compounds with antioxidant, antimicrobial, coloring, stabilizing, and texturizing properties. However, the bioactive potential alone does not guarantee that a by-product-derived ingredient is safe, effective, acceptable, scalable, or sustainable. Its use requires extraction, stabilization, real-food validation, safety assessment, sensory optimization, regulatory compliance, and sustainability evaluation. The review concludes that by-product-derived natural preservatives are both technological resources and educational tools. Future research and education should connect food preservation, label interpretation, food safety, sensory quality, sustainability evidence, and consumer decision-making to empower adolescents as critical consumers and informed agents of change in sustainable food systems. FAU - Silva, Paula AU - Silva P AUID- ORCID: 0000-0001-7204-6006 AD - Department of Microscopy, School of Medicine and Biomedical Sciences (ICBAS), University of Porto (U. Porto), Rua Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal. AD - iNOVA Media Lab, ICNOVA-NOVA Institute of Communication, NOVA School of Social Sciences and Humanities, Universidade NOVA de Lisboa, 1069-061 Lisbon, Portugal. LA - eng GR - 10/C06-i07/2024.P11729/European Union/ PT - Journal Article PT - Review DEP - 20260609 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Food Preservatives) SB - IM MH - Humans MH - Adolescent MH - Food Labeling MH - *Food Preservatives MH - *Food Preferences MH - *Food Industry MH - Consumer Behavior MH - Choice Behavior PMC - PMC13304532 OTO - NOTNLM OT - adolescent food literacy OT - circular food systems OT - food industry by-products OT - food labels OT - food waste valorization OT - natural preservatives OT - sustainable food choices COIS- The author declares no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 07:10 PMCR- 2026/06/09 CRDT- 2026/06/26 01:17 PHST- 2026/05/16 00:00 [received] PHST- 2026/06/05 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/09 00:00 [pmc-release] AID - nu18121859 [pii] AID - nutrients-18-01859 [pii] AID - 10.3390/nu18121859 [doi] PST - epublish SO - Nutrients. 2026 Jun 9;18(12):1859. doi: 10.3390/nu18121859. PMID- 42356236 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 8 TI - Feasibility and Preliminary Dietary Outcomes of the Smart Family Lifestyle Counseling Intervention in Greek Primary Care: A Single-Arm Pilot Study from Health4Eukids. LID - 10.3390/nu18121848 [doi] LID - 1848 AB - BACKGROUND: Childhood obesity is a complex public health issue in which parental perceptions and family dietary behaviors are pivotal. This study assessed the feasibility of the Smart Family lifestyle counseling intervention in Greek primary care. It explored changes in children's dietary behaviors relative to parental weight perception and Mediterranean diet adherence. METHODS: A single-arm pretest-posttest pilot study was conducted in Patras, Greece, from Health4EUKids Joint Action. The intervention consisted of four monthly face-to-face counseling sessions using the Smart Family methodology. In total, 49 parent-child dyads (aged 2-12 years) completed the program. Data collection included child anthropometric measurements, validated food frequency questionnaires, parental perception of child weight status, and parental Mediterranean diet adherence. RESULTS: Parents who underestimated their child's weight status had significantly higher Mediterranean diet scores than those who overestimated (p = 0.032); those with low adherence tended to overestimate and those with moderate adherence to underestimate. The largest reduction was observed for sweets and desserts (median -2.35 servings/week), with significant reductions in sugar-sweetened beverages, grains and cereals, whole wheat products, and dairy. Fish and vegetable intake increased significantly, but fruit intake did not change. Changes in fast food and red meat differed significantly across Mediterranean diet score tertiles, with larger decreases in the lower tertiles. CONCLUSIONS: Smart Family counseling was feasible to deliver through trained healthcare professionals in Greek primary care over four months, with reductions in selected discretionary foods observed alongside the intervention. Parental weight perception and Mediterranean diet adherence emerged as potential barriers to change although the findings are exploratory and require confirmation in a future controlled trial. FAU - Magriplis, Emmanuella AU - Magriplis E AUID- ORCID: 0000-0001-6517-6857 AD - Laboratory of Dietetics & Quality of Life, Department of Food Science and Human Nutrition, Agricultural University of Athens, 11855 Athens, Greece. AD - Laboratory of Public Health, Epidemiology and Quality of Life, Medical School, University of Patras, 26540 Patras, Greece. FAU - Myrintzou, Niki AU - Myrintzou N AD - Laboratory of Dietetics & Quality of Life, Department of Food Science and Human Nutrition, Agricultural University of Athens, 11855 Athens, Greece. FAU - Desli, Ios-Ioanna AU - Desli II AUID- ORCID: 0009-0005-5221-841X AD - Laboratory of Hygiene, Social & Preventive Medicine and Medical Statistics, School of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece. FAU - Papachatzi, Eleni AU - Papachatzi E AUID- ORCID: 0000-0003-4095-6827 AD - Department of Pediatrics, University General Hospital of Patras, 26504 Patras, Greece. FAU - Vantarakis, Apostolos AU - Vantarakis A AUID- ORCID: 0000-0003-4411-3739 AD - Laboratory of Public Health, Epidemiology and Quality of Life, Medical School, University of Patras, 26540 Patras, Greece. LA - eng GR - 101079944/European Health and Digital Executive Agency/ PT - Journal Article DEP - 20260608 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Pilot Projects MH - Greece MH - Male MH - Female MH - Feasibility Studies MH - Primary Health Care MH - *Counseling/methods MH - Child MH - Diet, Mediterranean MH - Child, Preschool MH - *Pediatric Obesity/prevention & control MH - *Life Style MH - Parents/psychology MH - *Feeding Behavior MH - Adult PMC - PMC13304528 OTO - NOTNLM OT - Mediterranean diet OT - Smart Family OT - childhood obesity OT - dietary behavior OT - family-based intervention OT - feasibility OT - parental perception OT - pilot study OT - primary care COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/06/26 06:38 MHDA- 2026/06/27 07:10 PMCR- 2026/06/08 CRDT- 2026/06/26 01:17 PHST- 2026/05/14 00:00 [received] PHST- 2026/06/01 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 06:38 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - nu18121848 [pii] AID - nutrients-18-01848 [pii] AID - 10.3390/nu18121848 [doi] PST - epublish SO - Nutrients. 2026 Jun 8;18(12):1848. doi: 10.3390/nu18121848. PMID- 42356232 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 12 DP - 2026 Jun 8 TI - Comparing a 7-Day Food Diary and Repeated 24-Hour Dietary Recall for Estimating Usual and Operational Definitions of Acute Intake in Danish Adults. LID - 10.3390/nu18121845 [doi] LID - 1845 AB - Background: Accurate dietary assessment is essential for estimating habitual and acute exposures. This study compared a 7-day food diary (7dFD) and repeated 24-h dietary recall (2x24hDR) for habitual and acute intake. Habitual fish and n-3 PUFA estimates were evaluated against whole-blood EPA and DHA, and acute intake of fish, rye bread, and coffee was explored using operational indicators. Methods: In a within-subject comparative design, 120 Danish adults aged 18-60 years completed both methods. Fish and n-3 fatty acid intakes were compared with whole-blood EPA and DHA. Usual fish intake from 2x24hDR was estimated using the Multiple Source Method (MSM) with Food Propensity Questionnaire (FPQ) data. Acute intake was assessed using single-day, consumption-day, single-meal, maximum-day, and meal-weighted estimates. Results: EPA, DHA, total fish, and fatty fish intakes estimated from the 7dFD and MSM-adjusted 2x24hDR correlated with biomarkers r = 0.23-0.46. Supplement inclusion improved EPA and DHA correlations (r = 0.26-0.59). The unadjusted 2x24hDR identified fewer fish consumers than the 7dFD (63% vs. 88%), whereas FPQ-based modelling identified 97%. Acute intake estimates varied by method and definition: the 2x24hDR produced higher short-term and upper- percentile estimates, while the 7dFD produced more stable distributions. Limitations include modest sample size, upper-percentile uncertainty, and non-equivalent supplement assessment. Conclusions: In this adult convenience sample, the 7dFD provided more stable habitual intake estimates, whereas the 2x24hDR produced higher short-term and upper-percentile estimates under the applied operational acute-intake definitions. These findings are context-dependent and should not be taken as evidence that either method is generally superior. FAU - Biltoft-Jensen, Anja AU - Biltoft-Jensen A AUID- ORCID: 0000-0002-6607-7575 AD - National Food Institute, Technical University of Denmark, 2800 Kongens Lyngby, Denmark. FAU - Aristizabal-Henao, Juan J AU - Aristizabal-Henao JJ AUID- ORCID: 0000-0002-2085-2396 AD - BPGbio, BPGbio Inc., Waltham, MA 02451, USA. AD - Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON N2L 3G1, Canada. FAU - Stark, Ken D AU - Stark KD AUID- ORCID: 0000-0001-7828-4072 AD - Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON N2L 3G1, Canada. FAU - Christensen, Tue AU - Christensen T AUID- ORCID: 0000-0001-7693-7359 AD - National Food Institute, Technical University of Denmark, 2800 Kongens Lyngby, Denmark. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260608 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 25167-62-8 (Docosahexaenoic Acids) RN - AAN7QOV9EA (Eicosapentaenoic Acid) RN - 0 (Fatty Acids, Omega-3) SB - IM MH - Humans MH - Adult MH - *Diet Records MH - Middle Aged MH - Male MH - Female MH - Denmark MH - Young Adult MH - Adolescent MH - *Mental Recall MH - *Diet MH - Docosahexaenoic Acids/blood/administration & dosage MH - Fishes MH - Eicosapentaenoic Acid/blood/administration & dosage MH - Seafood MH - Animals MH - Nutrition Assessment MH - *Feeding Behavior MH - Fatty Acids, Omega-3/blood/administration & dosage PMC - PMC13306161 OTO - NOTNLM OT - 24-h dietary recall OT - 7-day food diary OT - DHA OT - EPA OT - acute dietary intake OT - dietary assessment OT - fish intake OT - usual dietary intake OT - validation OT - whole-blood biomarkers COIS- K.S. is on the Board of Directors of the International Society for the Study of Fatty Acids and Lipids (ISSFAL). J.J.A.-H. completed this research at the University of Waterloo during his Ph.D. and currently works for BPGbio Inc., a company that provides lipidomic analyses. The company and the Board of Directors of ISSFAL had no role in the design of the study; in data collection, in analysis, or interpretation; in the writing of the manuscript; or in the decision to publish. A.B. and T.C declare no conflicts of interest. EDAT- 2026/06/26 06:38 MHDA- 2026/06/27 07:41 PMCR- 2026/06/08 CRDT- 2026/06/26 01:17 PHST- 2026/04/01 00:00 [received] PHST- 2026/05/27 00:00 [revised] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/06/27 07:41 [medline] PHST- 2026/06/26 06:38 [pubmed] PHST- 2026/06/26 01:17 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - nu18121845 [pii] AID - nutrients-18-01845 [pii] AID - 10.3390/nu18121845 [doi] PST - epublish SO - Nutrients. 2026 Jun 8;18(12):1845. doi: 10.3390/nu18121845. PMID- 42355722 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 12 DP - 2026 Jun 12 TI - Concordance Between Anthropometric Formula Predictions and Chest Radiograph-Confirmed Endotracheal Tube Depth in Young Infants: A Retrospective Cohort Study from Saudi Arabia. LID - 10.3390/jcm15124554 [doi] LID - 4554 AB - Background: Accurate endotracheal tube (ETT) insertion depth is critical in infants and young children, where tracheal malposition carries significant risk. Formula-based depth estimation is widely used at the bedside, but the performance of published formulas in children under two years of age admitted to a general PICU remains poorly characterized. Methods: A retrospective, single-center study was conducted at the PICU of King Saud Medical City, Riyadh. A total of 115 patients aged 1-24 months requiring orotracheal intubation were included. ETT depth was predicted using five established formulas: height-based [(H/10)+5], weight-based [W+6], ETT size-based [ETTx3], Lee weight-based [5.5+0.5W], and Lee height-based [3+0.1H]. Agreement between predicted and radiographically confirmed insertion depth was assessed using Lin's concordance correlation coefficient (CCC), Bland-Altman analysis, and clinical classification of predictions. Results: None of the five formulas achieved acceptable concordance (CCC < 0.75 for all). The height-based formula performed best among published formulas, with negligible bias and the highest proportion of clinically acceptable predictions. Both Lee formulas showed near-universal systematic underestimation and are not suitable for this age group. Over half of all intubations resulted in non-ideal ETT position on the first post-intubation chest X-ray. Novel cohort-derived regression equations outperformed all published formulas, with the weight-based equation (Depth = 0.385 x Weight + 9.145) emerging as the strongest predictor of insertion depth. Conclusions: No published formula achieved reliable concordance with radiographic ETT depth in children aged 1-24 months. The cohort-derived weight-based formula represents a more accurate bedside tool for this population and warrants prospective external validation. Post-intubation radiographic verification remains essential. FAU - Mavrych, Volodymyr AU - Mavrych V AUID- ORCID: 0009-0009-1159-4573 AD - College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. FAU - Majeed, Kashif AU - Majeed K AUID- ORCID: 0009-0007-0870-639X AD - Pediatric Intensive Care Unit, King Saud Medical City, Riyadh 12746, Saudi Arabia. FAU - Alshehri, Saleh AU - Alshehri S AUID- ORCID: 0009-0001-0388-5102 AD - Pediatric Intensive Care Unit, King Saud Medical City, Riyadh 12746, Saudi Arabia. FAU - Yasmin, Uzma AU - Yasmin U AUID- ORCID: 0009-0007-0147-8814 AD - Pediatric Emergency, King Saud University, Riyadh 11451, Saudi Arabia. FAU - Kashif, Muhammad Rayyan AU - Kashif MR AUID- ORCID: 0009-0004-1665-6888 AD - College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. FAU - Kashif, Ayesha AU - Kashif A AUID- ORCID: 0009-0001-6208-2131 AD - College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. FAU - Mahdi, Warda AU - Mahdi W AUID- ORCID: 0009-0006-7040-8222 AD - College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. FAU - Talha, Raghd AU - Talha R AUID- ORCID: 0009-0008-1238-8213 AD - College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. FAU - Bolgova, Olena AU - Bolgova O AUID- ORCID: 0009-0002-9496-9754 AD - College of Medicine, Alfaisal University, Riyadh 11533, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260612 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13301687 OTO - NOTNLM OT - concordance correlation coefficient OT - endotracheal tube OT - insertion depth OT - intensive care OT - pediatric intubation COIS- The authors declare no conflicts of interest, financial or otherwise. EDAT- 2026/06/26 13:10 MHDA- 2026/06/26 13:11 PMCR- 2026/06/12 CRDT- 2026/06/26 01:15 PHST- 2026/05/06 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/06/26 13:11 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:15 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - jcm15124554 [pii] AID - jcm-15-04554 [pii] AID - 10.3390/jcm15124554 [doi] PST - epublish SO - J Clin Med. 2026 Jun 12;15(12):4554. doi: 10.3390/jcm15124554. PMID- 42354516 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 12 DP - 2026 Jun 11 TI - Associations of Physical Fitness and Postural Balance with Psychosocial Well-Being in Early Adolescents: A School-Based Cross-Sectional Study. LID - 10.3390/healthcare14121659 [doi] LID - 1659 AB - Objective: This study aimed to examine the associations of morphological variables, maximal isometric handgrip strength (MIHS), and static postural balance with self-esteem, motivational climate, school climate, and health-related quality of life (HRQoL) in early adolescents. Methods: A cross-sectional study was conducted in 235 Chilean adolescents, in whom morphological variables, MIHS, and static postural balance were assessed using center-of-pressure (CoP) parameters under eyes-open (EO) and eyes-closed (EC) conditions. Psychosocial variables, including self-esteem, motivational climate, school climate, and HRQoL, were evaluated via validated questionnaires. Multiple linear regression analyses were performed to determine associations between physical and psychosocial variables. Results: Reduced CoP sway area and lower CoP velocity under eyes-closed conditions were significantly associated with higher self-esteem (R(2) = 0.168; p < 0.001). Greater non-dominant MIHS and younger age were associated with more favorable perceptions of a task-involving motivational climate (R(2) = 0.438; p < 0.001). Higher HRQoL scores were associated with male sex and better postural balance performance. Conclusions: Better static postural balance and greater muscle strength were associated with more favorable psychosocial outcomes, particularly self-esteem and HRQoL. However, these findings should be interpreted as associative rather than causal relationships due to the cross-sectional design. FAU - Aristegui-Mondaca, Juan AU - Aristegui-Mondaca J AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3530000, Chile. AD - Master Program of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3530000, Chile. FAU - Rodriguez Sepulveda, Gabriel AU - Rodriguez Sepulveda G AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3530000, Chile. FAU - Guzman-Munoz, Eduardo AU - Guzman-Munoz E AUID- ORCID: 0000-0001-7001-9004 AD - School of Kinesiology, Faculty of Health, Universidad Santo Tomas, Talca 3460000, Chile. AD - School of Physical Education Pedagogy, Faculty of Education, Universidad Autonoma de Chile, Talca 3460000, Chile. FAU - Hernandez-Martinez, Jordan AU - Hernandez-Martinez J AD - Department of Physical Activity Sciences, Universidad de Los Lagos, Osorno 5290000, Chile. AD - Department of Education, Faculty of Humanities, Universidad de la Serena, La Serena 1700000, Chile. FAU - Perez-Carcamo, Joaquin AU - Perez-Carcamo J AUID- ORCID: 0009-0006-0224-3745 AD - Department of Physical Activity Sciences, Universidad de Los Lagos, Osorno 5290000, Chile. FAU - Vasquez-Carrasco, Edgar AU - Vasquez-Carrasco E AUID- ORCID: 0000-0002-5359-6587 AD - School of Occupational Therapy, Faculty of Psychology, Universidad de Talca, Talca 3465548, Chile. AD - Centro de Investigacion en Ciencias Cognitivas, Faculty of Psychology, Universidad de Talca, Talca 3465548, Chile. FAU - Merellano-Navarro, Eugenio AU - Merellano-Navarro E AUID- ORCID: 0000-0002-1557-2285 AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3530000, Chile. FAU - Magnani Branco, Braulio Henrique AU - Magnani Branco BH AUID- ORCID: 0000-0002-4625-9128 AD - Graduate Program in Health Promotion, Cesumar University (UniCesumar), Maringa 87050-900, Brazil. FAU - Carmine-Pena, Eduardo AU - Carmine-Pena E AD - Carrera de Medicina, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile. FAU - Sandoval-Vasquez, Cristian AU - Sandoval-Vasquez C AUID- ORCID: 0000-0003-3184-6482 AD - Carrera de Terapia Ocupacional, Facultad de Ciencias de la Salud, Universidad Autonoma de Chile, Temuco 4810101, Chile. AD - Departamento de Medicina Interna, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile. FAU - Pena, Francisca AU - Pena F AD - Departamento de Medicina Interna, Facultad de Medicina, Universidad de La Frontera, Temuco 4811230, Chile. FAU - Valdes-Badilla, Pablo AU - Valdes-Badilla P AUID- ORCID: 0000-0002-3948-8280 AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3530000, Chile. AD - Sports Coach Career, Faculty of Life Sciences, Universidad Vina del Mar, Vina del Mar 2520000, Chile. LA - eng GR - 11220035/Fondo Nacional de Desarrollo Cientifico y Tecnologico/ PT - Journal Article DEP - 20260611 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13300289 OTO - NOTNLM OT - body composition OT - motivation OT - muscle strength OT - proprioception OT - psychological well-being OT - self-concept COIS- The authors declare that they have no conflicts of interest. EDAT- 2026/06/26 06:40 MHDA- 2026/06/26 06:41 PMCR- 2026/06/11 CRDT- 2026/06/26 01:11 PHST- 2026/04/16 00:00 [received] PHST- 2026/05/25 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/06/26 06:41 [medline] PHST- 2026/06/26 06:40 [pubmed] PHST- 2026/06/26 01:11 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - healthcare14121659 [pii] AID - healthcare-14-01659 [pii] AID - 10.3390/healthcare14121659 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jun 11;14(12):1659. doi: 10.3390/healthcare14121659. PMID- 42354340 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20261020 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 6 DP - 2026 Jun 18 TI - Risk of Diabetes Mellitus and Its Association with Cardiorespiratory Endurance in Zenu Indigenous People in Momil, Cordoba, Colombia. LID - 10.3390/ijerph23060811 [doi] LID - 811 AB - Type 2 diabetes mellitus (T2DM) represents a growing public health concern in Indigenous populations, where early risk identification remains limited. This study aimed to analyze the association between estimated T2DM risk and cardiorespiratory endurance in a Zenu Indigenous community in northern Colombia. A cross-sectional study was conducted among adults aged 18-70 years belonging to the Momil Urban Minor Indigenous Cabildo (Cordoba, Colombia). T2DM risk was assessed using the Finnish Diabetes Risk Score (FINDRISC), and cardiorespiratory endurance was evaluated through the Ruffier index. Associations were examined using a multivariable ordinal logistic regression model, and discriminative performance was evaluated using receiver operating characteristic (ROC) curve analysis. A total of 95 participants were included, most of whom were classified as low risk according to FINDRISC, while cardiorespiratory endurance assessed by the Ruffier index was predominantly classified as moderate to good. Age was significantly associated with higher risk categories in the adjusted model, whereas cardiorespiratory endurance was not significantly associated with estimated T2DM risk. The model demonstrated excellent discriminative capacity (AUC = 0.912; 95% CI: 0.850-0.973). In this population, age and family history were key determinants of estimated T2DM risk. Findings regarding cardiorespiratory endurance should be interpreted cautiously given sample size limitations. FAU - Montoya-Alvarez, Leily AU - Montoya-Alvarez L AUID- ORCID: 0000-0002-3806-7986 AD - MOSABI Research Group, Master's Programme in Epidemiology, University of Sinu, Monteria 230001, Colombia. FAU - Rodriguez-Sepulveda, Edgar AU - Rodriguez-Sepulveda E AUID- ORCID: 0000-0002-2715-3184 AD - Master's Programme in Epidemiology, University of Sinu, Monteria 230001, Colombia. FAU - Galeano-Paez, Claudia AU - Galeano-Paez C AUID- ORCID: 0000-0001-6865-4439 AD - Biomedical Research and Molecular Biology Group, University of Sinu, Monteria 230001, Colombia. FAU - Bru-Cordero, Osnamir Elias AU - Bru-Cordero OE AUID- ORCID: 0000-0001-9425-9475 AD - Academic Affairs Office, National University of Colombia, La Paz Campus, Kilometre 9, Valledupar 2022010, Colombia. FAU - Alcala-Tafur, Noelba AU - Alcala-Tafur N AUID- ORCID: 0009-0007-9135-4152 AD - Physical Therapy Program, University of Sinu, Monteria 230001, Colombia. LA - eng PT - Journal Article DEP - 20260618 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - Colombia/epidemiology MH - Middle Aged MH - Adult MH - Male MH - Female MH - *Diabetes Mellitus, Type 2/epidemiology/ethnology MH - Cross-Sectional Studies MH - Aged MH - Adolescent MH - Young Adult MH - Risk Factors MH - *Cardiorespiratory Fitness MH - *Physical Endurance MH - *Indians, South American PMC - PMC13299473 OTO - NOTNLM OT - cardiorespiratory endurance OT - indigenous population OT - risk factors OT - type 2 diabetes mellitus COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 06:38 MHDA- 2026/06/27 04:10 PMCR- 2026/06/18 CRDT- 2026/06/26 01:10 PHST- 2025/12/17 00:00 [received] PHST- 2026/03/12 00:00 [revised] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/26 06:38 [pubmed] PHST- 2026/06/26 01:10 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - ijerph23060811 [pii] AID - ijerph-23-00811 [pii] AID - 10.3390/ijerph23060811 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 Jun 18;23(6):811. doi: 10.3390/ijerph23060811. PMID- 42354335 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20261024 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 6 DP - 2026 Jun 17 TI - Association Between Physical Activity, Body Mass Index, and Aerobic Capacity in Periurban Adolescents. LID - 10.3390/ijerph23060806 [doi] LID - 806 AB - Adolescence is a critical window for health behavior consolidation, yet the combined influence of physical activity level (PAL) and the body mass index (BMI) on aerobic capacity remains understudied, especially in transitioning periurban environments. This study examined the association between PAL, BMI, and aerobic capacity in adolescents from Monteria, Colombia. A cross-sectional study was conducted among 112 adolescents (aged 12-17 years). Aerobic capacity was assessed using the 20 m shuttle run test (Course Navette), and PAL was measured via the validated Assessment of Physical Activity Levels Questionnaire (APALQ), following standard fitness assessment protocols. Multivariable linear regression models were utilized to estimate independent associations, adjusting for age and sex. The multivariable model was significant (F = 8.45; p < 0.001), explaining 21% of the variance in aerobic capacity (adjusted R(2) = 0.21). PAL was positively and independently associated with aerobic capacity (B = 0.22; 95% CI: 0.05-0.38; p = 0.010), regardless of BMI. While age showed a positive association (B = 0.09; p = 0.032) and sex was inversely associated (B = -0.39; p < 0.001), BMI did not emerge as an independent predictor in the adjusted model (B = -0.04; p = 0.080). Aerobic capacity in adolescents is more consistently explained by behavioral factors (what they "do") than by anthropometric status (what they "weigh"). These findings support a paradigm shift in pediatric public health, prioritizing high-intensity movement overweight control to improve cardiorespiratory fitness in transitioning urban territories. FAU - Sepulveda, Fabian AU - Sepulveda F AUID- ORCID: 0000-0002-2715-3184 AD - Programa de Maestria en Epidemiologia de la, Universidad del Sinu-Elias Bechara Zainum, Monteria 230001, Colombia. FAU - Penata-Taborda, Ana AU - Penata-Taborda A AUID- ORCID: 0000-0001-8698-612X AD - Grupo de Investigacion Biomedica y Biologia Molecular, Universidad del Sinu-Elias Bechara Zainum, Monteria 230001, Colombia. FAU - Bru-Cordero, Osnamir AU - Bru-Cordero O AUID- ORCID: 0000-0001-9425-9475 AD - Direccion Academica, Universidad Nacional de Colombia Sede de La Paz, Cesar 200017, Colombia. FAU - Montoya-Alvarez, Leily AU - Montoya-Alvarez L AUID- ORCID: 0000-0002-3806-7986 AD - Grupo de Investigacion MOSABI, Universidad del Sinu-Elias Bechara Zainum, Monteria 230001, Colombia. FAU - Humanez-Alvarez, Alicia AU - Humanez-Alvarez A AUID- ORCID: 0000-0002-3114-6235 AD - Grupo de Investigacion Biomedica y Biologia Molecular, Universidad del Sinu-Elias Bechara Zainum, Monteria 230001, Colombia. LA - eng PT - Journal Article DEP - 20260617 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - *Body Mass Index MH - Adolescent MH - Female MH - Male MH - Cross-Sectional Studies MH - Child MH - *Exercise MH - Colombia MH - *Cardiorespiratory Fitness MH - *Physical Fitness PMC - PMC13299683 OTO - NOTNLM OT - behavioral determinants and multivariable analysis OT - cardiorespiratory fitness OT - nutritional status OT - periurban health COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; the collection, analyses, or interpretation of data; the writing of the manuscript; or the decision to publish the results. EDAT- 2026/06/26 13:10 MHDA- 2026/06/27 04:10 PMCR- 2026/06/17 CRDT- 2026/06/26 01:10 PHST- 2025/12/15 00:00 [received] PHST- 2026/03/02 00:00 [revised] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:10 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - ijerph23060806 [pii] AID - ijerph-23-00806 [pii] AID - 10.3390/ijerph23060806 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 Jun 17;23(6):806. doi: 10.3390/ijerph23060806. PMID- 42354263 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 6 DP - 2026 May 30 TI - Psychological Distress and Associated Factors Among High-School Students in Makkah, Saudi Arabia: A Cross-Sectional Study Using the Arabic GHQ-30. LID - 10.3390/ijerph23060733 [doi] LID - 733 AB - BACKGROUND: Mental health problems often begin in adolescence, yet early detection and intervention remain limited. This study assesses the prevalence of psychological distress and its correlates among high-school students in Makkah, Saudi Arabia, and explores whether specific symptom clusters of depression, anxiety and bipolar/mania can be identified using the General Health Questionnaire-30 (GHQ-30). METHODS: A cross-sectional survey was conducted during the 2025-2026 academic year using stratified cluster sampling. A total of 535 students aged 15-18 years completed a questionnaire containing the validated Arabic GHQ-30 and demographic, socioeconomic and lifestyle items. The GHQ-30 was scored with binary 0-0-1-1 scoring (cut-off >/= 6) to define cases of psychological distress. Item clusters were used to screen for probable depression, anxiety and bipolar/mania. Descriptive statistics characterized the sample. Associations were examined using chi-square tests and multivariable logistic regression. RESULTS: Overall, 70.5% of participants screened positive for psychological distress. The prevalences of probable depression, anxiety and bipolar/mania were 33.1%, 28.2% and 31.2%, respectively. In adjusted models, female gender, insufficient sleep, lack of physical activity and exposure to bullying were associated with increased odds of psychological distress; longer sleep was protective. History of mental health conditions was a strong predictor of probable depression, whereas medication use was protective. Older age and higher paternal education were protective for anxiety. Bullying was the most consistent predictor across all symptom clusters. CONCLUSIONS: Psychological distress is highly prevalent among Makkah high-school students. Key determinants include gender, sleep duration, lack of physical activity and bullying. Routine school-based mental health screening, sleep-hygiene education, anti-bullying initiatives and early referral pathways are warranted. Further research should examine and validate GHQ-30 item clusters for specific disorders. FAU - Hashim, Arwa Hesham AU - Hashim AH AD - Saudi Board Program of Preventive Medicine, Program, Makkah Health Cluster, Makkah 24242, Saudi Arabia. FAU - Khan, Adeel Ahmed AU - Khan AA AUID- ORCID: 0000-0003-2724-8113 AD - Saudi Board Program of Preventive Medicine, Program, Makkah Health Cluster, Makkah 24242, Saudi Arabia. FAU - Hayat, Aalia Akhtar AU - Hayat AA AUID- ORCID: 0000-0001-6609-0879 AD - Department of Child Psychiatry, Maternity and Children Hospital, Makkah Health Cluster, Makkah 24242, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260530 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Adolescent MH - Cross-Sectional Studies MH - Female MH - *Students/psychology/statistics & numerical data MH - Male MH - *Psychological Distress MH - Surveys and Questionnaires MH - Prevalence MH - *Stress, Psychological/epidemiology MH - Depression/epidemiology PMC - PMC13299696 OTO - NOTNLM OT - GHQ-30 OT - Saudi Arabia OT - adolescent mental health OT - bullying OT - cross-sectional study OT - high-school students OT - physical activity OT - psychological distress OT - school-based screening OT - sleep duration COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 06:38 MHDA- 2026/06/27 07:10 PMCR- 2026/05/30 CRDT- 2026/06/26 01:10 PHST- 2026/04/20 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/06/27 07:10 [medline] PHST- 2026/06/26 06:38 [pubmed] PHST- 2026/06/26 01:10 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - ijerph23060733 [pii] AID - ijerph-23-00733 [pii] AID - 10.3390/ijerph23060733 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 May 30;23(6):733. doi: 10.3390/ijerph23060733. PMID- 42354229 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 6 DP - 2026 May 25 TI - Prevalence, Risk Factors, and Preventive Strategies of Hypertension Among Young Adults in the United Arab Emirates. LID - 10.3390/ijerph23060698 [doi] LID - 698 AB - Background: Hypertension is one of the most common noncommunicable diseases. Objectives: This research assessed the magnitude of hypertension among young adults, identified its key determinants, and explored potential strategies adopted for prevention. Methods: A cross-sectional design was employed, including 1606 participants aged 18 years and older, recruited through convenience sampling from universities and community settings. Data were collected using a content-validated questionnaire covering sociodemographic information, personal and family medical history, and lifestyle habits. Results: Of the participants, 993 (61.8%) reported hypertension, nearly double previous national estimates. Male gender, age >/= 30 years, and family history were significant risk factors, along with smoking, alcohol use, sedentary lifestyle, and unhealthy diet, while physical activity and dietary modification were protective. Despite high prevalence, only 22.1% had controlled blood pressure and 17.8% adhered to medication, with 51.5% relying on herbal remedies. Conclusions: These findings highlight the urgent need for early screening, youth-focused awareness, and culturally tailored interventions to reduce hypertension and prevent long-term cardiovascular complications. Hypertension among young adults in the UAE is a major public health concern, requiring integrated strategies combining education, lifestyle modification, and medical management to improve outcomes. FAU - Raid Hussain Aljubori, Aws AU - Raid Hussain Aljubori A AD - Community Medicine, College of Medicine, Gulf Medical University, Ajman P.O. Box 4184, United Arab Emirates. FAU - Abutartour, Mahmoud Nabil M AU - Abutartour MNM AD - Community Medicine, College of Medicine, Gulf Medical University, Ajman P.O. Box 4184, United Arab Emirates. FAU - Abdulla Darwish Ali, Ibrahim AU - Abdulla Darwish Ali I AD - Community Medicine, College of Medicine, Gulf Medical University, Ajman P.O. Box 4184, United Arab Emirates. FAU - Ghaith Al Haj Younes, Mohammed AU - Ghaith Al Haj Younes M AD - Community Medicine, College of Medicine, Gulf Medical University, Ajman P.O. Box 4184, United Arab Emirates. FAU - Muttappallymyalil, Jayakumary AU - Muttappallymyalil J AD - Community Medicine, College of Medicine, Gulf Medical University, Ajman P.O. Box 4184, United Arab Emirates. LA - eng PT - Journal Article DEP - 20260525 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - *Hypertension/epidemiology/prevention & control/etiology MH - Male MH - Female MH - Risk Factors MH - United Arab Emirates/epidemiology MH - Prevalence MH - Young Adult MH - Cross-Sectional Studies MH - Adult MH - Adolescent MH - Life Style MH - Surveys and Questionnaires PMC - PMC13299299 OTO - NOTNLM OT - UAE OT - hypertension OT - prevalence OT - preventive practices OT - young adults COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/27 04:10 PMCR- 2026/05/25 CRDT- 2026/06/26 01:10 PHST- 2026/04/14 00:00 [received] PHST- 2026/05/05 00:00 [revised] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:10 [entrez] PHST- 2026/05/25 00:00 [pmc-release] AID - ijerph23060698 [pii] AID - ijerph-23-00698 [pii] AID - 10.3390/ijerph23060698 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 May 25;23(6):698. doi: 10.3390/ijerph23060698. PMID- 42354070 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2304-8158 (Print) IS - 2304-8158 (Electronic) IS - 2304-8158 (Linking) VI - 15 IP - 12 DP - 2026 Jun 11 TI - Aflatoxin M1 in Milk from South-Central and Northwest China: Prevalence and Integrated Risk Characterization for Different Age-Sex Groups of Consumers. LID - 10.3390/foods15122102 [doi] LID - 2102 AB - Aflatoxin M1 (AFM1) is a Group 1 human carcinogen that poses a public health risk through milk contamination. This study investigated AFM1 contamination in pasteurized and ultra-high temperature (UHT) milk from south-central and northwest China, and assessed the associated health risks for consumers based on age, sex, and milk consumption scenarios. In total, 902 milk samples (493 pasteurized, 409 UHT) were collected during the summer and winter seasons of 2023-2024. AFM1 levels were determined using a validated enzyme-linked immunosorbent assay. AFM1 was detected in 75.39% of samples (mean concentration, 12.35 +/- 10.27 ng/L; maximum, 75.57 ng/L). While 1.55% of samples exceeded the EU maximum limit (50 ng/L), all complied with the Chinese limit (500 ng/L). Contamination was significantly higher in south-central China than northwest China, higher in winter than summer, and higher in pasteurized milk than UHT milk (p < 0.05). Preschool children in south-central China consuming 400 mL/day of milk are the group with the highest AFM11 exposure risk. And the margin of exposure and population risk of liver cancer suggested little carcinogenic risk. Therefore, targeted monitoring strategies for AFM1 in milk are recommended, along with dietary guidance for high-risk groups, especially vulnerable young children, to mitigate exposure. FAU - Zhang, Xue AU - Zhang X AD - School of Animal Science and Nutrition Engineering, Wuhan Polytechnic University, Wuhan 430023, China. FAU - Zhang, Ting AU - Zhang T AD - School of Animal Science and Nutrition Engineering, Wuhan Polytechnic University, Wuhan 430023, China. FAU - Zhang, Jie AU - Zhang J AD - School of Animal Science and Nutrition Engineering, Wuhan Polytechnic University, Wuhan 430023, China. FAU - Qiu, Yinsheng AU - Qiu Y AD - School of Animal Science and Nutrition Engineering, Wuhan Polytechnic University, Wuhan 430023, China. FAU - Lu, Qirong AU - Lu Q AD - School of Animal Science and Nutrition Engineering, Wuhan Polytechnic University, Wuhan 430023, China. FAU - Xiong, Jianglin AU - Xiong J AD - School of Animal Science and Nutrition Engineering, Wuhan Polytechnic University, Wuhan 430023, China. FAU - Wang, Chong AU - Wang C AUID- ORCID: 0000-0003-2770-4836 AD - Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, College of Animal Science and Technology & College of Veterinary Medicine, Zhejiang A&F University, Hangzhou 311300, China. LA - eng GR - 2025C04036/Zhejiang Provincial Science and Technology Plan Project/ GR - 2025ZDXT15-03/Zhejiang Animal Husbandry Industry Technology Project and Cooperative Extension Plan of Major Agricultural Technologies of Zhejiang Province/ GR - 2026SNJF067/Science and Technology Cooperation Plan of "SanNongJiuFang" of Zhejiang Province/ GR - K2024-1-1-17, K2024-1-1-18, K2024-1-1-19/Jiaxing Commissioner Project/ PT - Journal Article DEP - 20260611 PL - Switzerland TA - Foods JT - Foods (Basel, Switzerland) JID - 101670569 PMC - PMC13298350 OTO - NOTNLM OT - China OT - aflatoxin M1 OT - milk OT - prevalence OT - risk characterization COIS- The authors declare that there is no conflict of interest. EDAT- 2026/06/26 16:10 MHDA- 2026/06/26 16:11 PMCR- 2026/06/11 CRDT- 2026/06/26 01:09 PHST- 2026/05/09 00:00 [received] PHST- 2026/06/06 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/06/26 16:11 [medline] PHST- 2026/06/26 16:10 [pubmed] PHST- 2026/06/26 01:09 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - foods15122102 [pii] AID - foods-15-02102 [pii] AID - 10.3390/foods15122102 [doi] PST - epublish SO - Foods. 2026 Jun 11;15(12):2102. doi: 10.3390/foods15122102. PMID- 42353995 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 6 DP - 2026 Jun 17 TI - Physical Activity as a Mediator of the Relationship Between Mediterranean Diet Adherence and Anxiety Symptoms in Chilean Adolescents: A Cross-Sectional Study. LID - 10.3390/children13060825 [doi] LID - 825 AB - BACKGROUND: Adolescent mental health is a global concern, with lifestyle factors such as diet and physical activity (PA) playing a crucial role. While the Mediterranean Diet adherence (MDA) is known for its neuroprotective benefits on mental health, the mechanisms by which they are related remain unclear. Therefore, the aim of this study was twofold: (1) to examine the associations between MDA, PA, and screen time (ST) with anxiety symptoms, depression, stress, and total psychological distress in Chilean adolescents; and (2) to determine whether PA mediates the relationship between MDA and anxiety symptoms. METHODS: A cross-sectional study was conducted with 322 Chilean school-aged adolescents 158 males and 164 females (14.98 +/- 1.96 years). Mental health outcomes (depression, anxiety, and stress) and lifestyle behaviors, including MDA, PA, and ST, were comprehensively assessed using validated self-reported questionnaires. RESULTS: After adjusting for age and sex, multiple linear regression models showed that higher MDA was significantly and inversely associated with anxiety (b = -0.23, p = 0.044), stress (b = -0.25, p = 0.022), and total psychological distress (b = -0.72, p = 0.022). Conversely, ST was identified as a consistent risk factor, positively predicting higher levels of anxiety (b = 0.45, p = 0.008), stress (b = 0.42, p = 0.008), and total distress (b = 1.11, p = 0.014). Furthermore, PA was inversely linked to anxiety (b = -0.35, p = 0.013) and successfully mediated the relationship between MDA and anxiety symptoms (Indirect Effect = -0.047, 95% CI: -0.10 to -0.01). No significant mediation effects were observed for depression or stress. CONCLUSIONS: The present study identifies robust inverse associations between MDA and symptoms of anxiety, depression, and stress in Chilean adolescents. A key finding is the specific pattern of relationships observed: while higher MDA is directly linked to lower levels of depression and stress, its association with anxiety is shared with levels of PA. Despite these findings, the cross-sectional nature of the study limits the establishment of causal relationships, and further longitudinal research is needed to confirm these directional pathways. FAU - Caamano-Navarrete, Felipe AU - Caamano-Navarrete F AUID- ORCID: 0000-0002-6884-589X AD - Physical Education Career, Universidad Autonoma de Chile, Temuco 4780000, Chile. FAU - Hernandez-Mosqueira, Claudio AU - Hernandez-Mosqueira C AUID- ORCID: 0000-0001-9392-2319 AD - Departamento de Ciencias de la Educacion, Universidad del Bio-Bio, Chillan 3780000, Chile. FAU - Contreras-Diaz, Guido AU - Contreras-Diaz G AD - Escuela de Kinesiologia, Facultad de Ciencias de la Rehabilitacion y Calidad de Vida, Universidad San Sebastian, Lago Panguipulli 1390, Puerto Montt 5501842, Chile. FAU - Del-Cuerpo, Indya AU - Del-Cuerpo I AUID- ORCID: 0000-0002-2949-7896 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, 18071 Granada, Spain. FAU - Jerez-Mayorga, Daniel AU - Jerez-Mayorga D AUID- ORCID: 0000-0002-6878-8004 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, 18071 Granada, Spain. AD - Exercise and Rehabilitation Sciences Institute, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile. FAU - Herrera-Valenzuela, Tomas AU - Herrera-Valenzuela T AUID- ORCID: 0000-0002-5219-5896 AD - Department of Physical Activity, Sports and Health Sciences, Faculty of Medical Sciences, Universidad de Santiago de Chile (USACH), Santiago 8370003, Chile. FAU - Guzman-Munoz, Eduardo AU - Guzman-Munoz E AUID- ORCID: 0000-0001-7001-9004 AD - School of Kinesiology, Faculty of Health, Universidad Santo Tomas, Talca 3460000, Chile. FAU - Hernandez-Martinez, Jordan AU - Hernandez-Martinez J AD - Department of Physical Activity Sciences, Universidad de Los Lagos, Osorno 5290000, Chile. AD - Department of Education, Faculty of Humanities, Universidad de la Serena, La Serena 1700000, Chile. FAU - Valdes-Badilla, Pablo AU - Valdes-Badilla P AUID- ORCID: 0000-0002-3948-8280 AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca 3460000, Chile. AD - Sports Coach Career, Faculty of Life Sciences, Universidad Vina del Mar, Vina del Mar 2520000, Chile. FAU - Nunez-Espinosa, Cristian AU - Nunez-Espinosa C AUID- ORCID: 0000-0002-9896-7062 AD - Escuela de Medicina, Universidad de Magallanes, Punta Arenas 6200000, Chile. AD - Centro Asistencial Docente y de Investigacion, Universidad de Magallanes, Punta Arenas 6200000, Chile. AD - Red Interuniversitaria de Envejecimiento Saludable de Latinoamerica y Caribe (RIES-LAC), Punta Arenas 6200000, Chile. FAU - Delgado-Floody, Pedro AU - Delgado-Floody P AUID- ORCID: 0000-0001-9952-993X AD - Department of Physical Education, Sport and Recreation, Universidad de La Frontera, Temuco 4811230, Chile. LA - eng PT - Journal Article DEP - 20260617 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13298326 OTO - NOTNLM OT - adolescents OT - anxiety OT - depression OT - mediation analysis OT - mediterranean diet OT - mental health OT - physical activity COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 13:10 MHDA- 2026/06/26 13:11 PMCR- 2026/06/17 CRDT- 2026/06/26 01:09 PHST- 2026/04/30 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/06/26 13:11 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:09 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - children13060825 [pii] AID - children-13-00825 [pii] AID - 10.3390/children13060825 [doi] PST - epublish SO - Children (Basel). 2026 Jun 17;13(6):825. doi: 10.3390/children13060825. PMID- 42353939 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 6 DP - 2026 Jun 1 TI - Moving Beyond Technique: A Conceptual Perspective for the Cuevas Medek Exercise Aligned with Modern Neuroscience. LID - 10.3390/children13060769 [doi] LID - 769 AB - Despite its increasing use in pediatric neurorehabilitation, Cuevas Medek Exercise (CME) remains rooted in clinical tradition, with limited theoretical articulation in relation to contemporary models of motor development, control, and learning. While clinical observations and reports from practice suggest possible functional benefits in children with motor delays, the absence of a conceptual framework limits its integration into evidence-informed physical therapy practice and education. This perspective proposes a conceptual model for CME that aligns its core principles with current theoretical constructs in motor behavior and developmental neuroscience. By examining key elements of CME-such as distal initiation, postural challenge, and task variability-through the lens of affordances, self-organization, and experience-dependent plasticity, the article presents CME not merely as a technique, but as a conceptual developmental approach informed by embodied action. We argue that such reframing may support more rigorous clinical reasoning, contribute to interdisciplinary dialogue, and inform a theoretical basis for future research exploring the proposed mechanisms and potential effects of CME. More broadly, this perspective contributes to ongoing discussions on how clinically derived interventions can be conceptually integrated within contemporary rehabilitation science. While the present article does not provide empirical validation, it offers a theoretical framework intended to inform future investigation and critical reflection in pediatric physical therapy. FAU - Becker, Cristiano AU - Becker C AD - CB Center Therapies and CME Courses, Cunha Pora 89890-000, SC, Brazil. FAU - Goulardins, Juliana Barbosa AU - Goulardins JB AUID- ORCID: 0000-0003-2639-6122 AD - Escola Bahiana de Medicina e Saude Publica, Salvador 40290-000, BA, Brazil. FAU - Marques, Juliana Cristina Fernandes Bilhar AU - Marques JCFB AUID- ORCID: 0000-0003-0429-1258 AD - Neurologic Rehabilitation Clinic, Sao Paulo 03410-010, SP, Brazil. FAU - Gajardo, Ramon Jeronimo Cuevas AU - Gajardo RJC AD - CME Therapy Spa, Santiago 7550000, Chile. LA - eng PT - Journal Article DEP - 20260601 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13296991 OTO - NOTNLM OT - Cuevas Medek Exercise OT - motor skills OT - neuroplasticity OT - pediatric rehabilitation OT - physical therapy COIS- J.B.G. is a certified Cuevas Medek Exercise (CME) Level 1 therapist, and J.C.B.F.M. is a certified CME Level 2 therapist. C.B. is a CME Level 4 therapist and certified instructor of the method. R.J.C.G., co-author of this manuscript, is the developer of the Cuevas Medek Exercise approach and has family ties to the founder of the method. The authors declare that the present manuscript is a conceptual perspective article and does not report experimental efficacy data or commercial evaluation of CME. The authors further declare that these affiliations did not influence the content or interpretation of this manuscript. EDAT- 2026/06/26 06:39 MHDA- 2026/06/26 06:40 PMCR- 2026/06/01 CRDT- 2026/06/26 01:09 PHST- 2026/04/29 00:00 [received] PHST- 2026/05/28 00:00 [revised] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/06/26 06:40 [medline] PHST- 2026/06/26 06:39 [pubmed] PHST- 2026/06/26 01:09 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - children13060769 [pii] AID - children-13-00769 [pii] AID - 10.3390/children13060769 [doi] PST - epublish SO - Children (Basel). 2026 Jun 1;13(6):769. doi: 10.3390/children13060769. PMID- 42353900 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 6 DP - 2026 May 24 TI - Serum Zonulin and Chitinase (CHI3L1) as Biomarkers of Intestinal Permeability and Disease Activity in Pediatric Celiac Disease. LID - 10.3390/children13060730 [doi] LID - 730 AB - Objectives: To evaluate serum zonulin and CHI3L1 as indicators of intestinal permeability and disease activity in pediatric celiac disease and to explore their associations with histopathological findings and nutritional status. Methods: This prospective cross-sectional study included 131 pediatric patients with CD (aged 2-18 years) and 42 healthy controls. Patients were classified as newly diagnosed, gluten-free diet (GFD)-adherent, or GFD-nonadherent. Body mass index was calculated, and serum levels of micronutrients, zonulin, and CHI3L1 were measured using a sandwich enzyme-linked immunosorbent assay. Associations with histopathological findings, serological markers, and nutritional parameters were analyzed. Results: Age and sex distributions were similar across groups (mean age: 10.9 +/- 4.27 years). Serum zonulin and CHI3L1 levels were moderately positively correlated (r = 0.525, p < 0.001). Both biomarkers showed significant positive correlations with Marsh scores and tissue transglutaminase IgA levels. Zonulin was inversely correlated with hemoglobin, serum iron, and ferritin, whereas CHI3L1 showed negative correlations with hemoglobin and folate. Parathyroid hormone levels were positively correlated with both biomarkers. Receiver operating characteristic analysis demonstrated acceptable discriminatory performance for distinguishing CD from controls (AUC: 0.713 for zonulin and 0.709 for CHI3L1). Conclusions: Serum zonulin and CHI3L1 levels are associated with disease activity and mucosal injury in pediatric CD but do not directly reflect micronutrient status. These biomarkers may complement conventional monitoring parameters by providing additional information on intestinal permeability and inflammatory activity during follow-up. FAU - Tok, Aysegul Cebe AU - Tok AC AD - Department of Pediatric Gastroenterology, Etlik City Hospital, University of Health Sciences, Ankara 06010, Turkiye. FAU - Sayin, Oya AU - Sayin O AUID- ORCID: 0000-0003-0879-9091 AD - Department of Medical Laboratory Techniques, Vocational School of Health Services, Dokuz Eylul University, Izmir 35340, Turkiye. LA - eng PT - Journal Article DEP - 20260524 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13298287 OTO - NOTNLM OT - Marsh classification OT - gluten-free diet adherence OT - intestinal barrier function OT - mucosal injury OT - serological biomarkers COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 10:10 MHDA- 2026/06/26 10:11 PMCR- 2026/05/24 CRDT- 2026/06/26 01:09 PHST- 2026/04/11 00:00 [received] PHST- 2026/05/16 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/06/26 10:11 [medline] PHST- 2026/06/26 10:10 [pubmed] PHST- 2026/06/26 01:09 [entrez] PHST- 2026/05/24 00:00 [pmc-release] AID - children13060730 [pii] AID - children-13-00730 [pii] AID - 10.3390/children13060730 [doi] PST - epublish SO - Children (Basel). 2026 May 24;13(6):730. doi: 10.3390/children13060730. PMID- 42352833 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 6 DP - 2026 Jun 15 TI - Daily Routines and Habits in Individuals with Attention Deficit Hyperactivity Disorder: A Scoping Review. LID - 10.3390/bs16061000 [doi] LID - 1000 AB - This scoping review examined the current literature on routines and habits in individuals with attention deficit hyperactivity disorder (ADHD). To our knowledge, research in this area remains limited. Therefore, this review mapped which areas of daily routines are most affected in children and adults with ADHD and explored related assessments and interventions. A comprehensive search was conducted across four databases: PubMed, Scopus, CINAHL, and PsycINFO, using keywords including "attention deficit hyperactivity disorder," "ADHD," "routine," "habit," and "lifestyle." The findings identified four main domains in which individuals with ADHD experience difficulties: sleep hygiene, feeding, physical activity, and sedentary behaviors, with sleep hygiene addressed in more than half of the included studies. Study habits were addressed in only one included study. Among the 31 included studies, six involved interventions. The review also found that no validated assessment was specifically designed to measure routines or habits in individuals with ADHD, and that broader measures of routines, habits, or lifestyle were often non-validated or developed for a single project. Overall, the existing studies were concentrated primarily in pediatric populations, with limited research involving adults. These findings highlight important gaps in the literature and underscore the need for more research on routines and habits in adults with ADHD. They also support the development of assessments and interventions that specifically address these areas. FAU - Almudayfir, Ibrahim AU - Almudayfir I AD - Occupational Therapy Department, College of Applied Medical Sciences, King Saud bin Abdulaziz University for Health Sciences, Riyadh 1148, Saudi Arabia. AD - Rehabilitation Science Program, University of Alabama at Birmingham, Birmingham, AL 35294, USA. FAU - Abdulkarim, Lama AU - Abdulkarim L AD - Independent Researcher, Riyadh 13343, Saudi Arabia. FAU - Rosenstein, Rachael AU - Rosenstein R AD - Outreach Therapy, Pittsburgh, PA 15213, USA. FAU - Yuen, Hon K AU - Yuen HK AUID- ORCID: 0000-0001-5696-1845 AD - Department of Occupational Therapy, University of Alabama at Birmingham, Birmingham, AL 35294, USA. LA - eng PT - Journal Article PT - Review DEP - 20260615 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13295911 OTO - NOTNLM OT - ADHD OT - habit OT - lifestyle OT - routine OT - scoping review COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 13:10 MHDA- 2026/06/26 13:11 PMCR- 2026/06/15 CRDT- 2026/06/26 01:05 PHST- 2026/02/22 00:00 [received] PHST- 2026/05/07 00:00 [revised] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/06/26 13:11 [medline] PHST- 2026/06/26 13:10 [pubmed] PHST- 2026/06/26 01:05 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - bs16061000 [pii] AID - behavsci-16-01000 [pii] AID - 10.3390/bs16061000 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Jun 15;16(6):1000. doi: 10.3390/bs16061000. PMID- 42352707 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 6 DP - 2026 Jun 1 TI - Predicting Intrinsic Motivation After an Adventure Education Program in Primary Schools: Enjoyment, Self-Confidence and Resilience According to Gender. LID - 10.3390/bs16060874 [doi] LID - 874 AB - This study aimed to describe the pre-post changes in intrinsic motivation observed following the implementation of a parkour-based Adventure Education (AE) program in primary school students, and to examine the role of enjoyment, self-confidence, and resilience as variables statistically associated with intrinsic motivation, considering differences according to time (pre-test-post-test) and gender. The sample consisted of 492 fifth- and sixth-grade primary education students (249 boys and 243 girls) with a mean age of 10.67 years, enrolled in 12 Spanish schools. A quasi-experimental design with pre-test and post-test measures was used following the implementation of a seven-session program based on the Pedagogical Model of Adventure Education. Data were collected using instruments validated in the Spanish population: the intrinsic motivation subscale of the Perceived Locus of Causality Scale, the Physical Activity Enjoyment Scale to measure enjoyment, the self-confidence subscale of the Competitive State Anxiety Inventory, and the Connor-Davidson Resilience Scale to assess resilience. Statistical analysis was performed using SPSS 28.0 software, conducting descriptive analyses, correlations, and hierarchical multiple linear regressions to examine the statistical associations among the variables at each measurement point, along with a 2 x 2 repeated-measures ANOVA (time x gender). Post-test scores were significantly higher than pre-test scores for intrinsic motivation, enjoyment, self-confidence and resilience. Enjoyment was the variable most strongly statistically associated with intrinsic motivation, followed by self-confidence and resilience. The ANOVA showed a significant main effect of time, while no significant time x gender interaction was detected, meaning that the study found no evidence that the pre-post change differed between boys and girls. Given the single-arm pre-post design and the absence of a control group, these findings should be interpreted as preliminary descriptive evidence of pre-post change and associations, and not as a causal test of the program's effectiveness. FAU - Calmaestra-Sanchez, Andres AU - Calmaestra-Sanchez A AUID- ORCID: 0000-0001-6916-2284 AD - Department of Didactics of Musical, Plastic and Bodily Expression, University of Granada, 18015 Granada, Spain. FAU - Baena-Extremera, Antonio AU - Baena-Extremera A AUID- ORCID: 0000-0002-3597-4038 AD - Department of Didactics of Musical, Plastic and Bodily Expression, University of Granada, 18015 Granada, Spain. FAU - Gonzalez-Ruiz, Josue AU - Gonzalez-Ruiz J AUID- ORCID: 0000-0003-4977-9433 AD - Department of Didactics of Musical, Plastic and Bodily Expression, University of Granada, 18015 Granada, Spain. FAU - Sanchez-Fuentes, Jose Antonio AU - Sanchez-Fuentes JA AUID- ORCID: 0000-0003-3575-3507 AD - Research Group Movement Sciences and Sport (MS&SPORT), Department of Physical Activity and Sport, Faculty of Sport Sciences, University of Murcia, 30720 Murcia, Spain. LA - eng PT - Journal Article DEP - 20260601 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13296333 OTO - NOTNLM OT - adventure education OT - motivation OT - parkour COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 06:38 MHDA- 2026/06/26 06:39 PMCR- 2026/06/01 CRDT- 2026/06/26 01:05 PHST- 2026/04/06 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/26 06:39 [medline] PHST- 2026/06/26 06:38 [pubmed] PHST- 2026/06/26 01:05 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - bs16060874 [pii] AID - behavsci-16-00874 [pii] AID - 10.3390/bs16060874 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Jun 1;16(6):874. doi: 10.3390/bs16060874. PMID- 42351663 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260813 IS - 2227-9059 (Print) IS - 2227-9059 (Electronic) IS - 2227-9059 (Linking) VI - 14 IP - 6 DP - 2026 May 29 TI - Organoids in Pediatric Congenital Hepatobiliary Diseases: Current Status and Progress in Clinical Translational Research. LID - 10.3390/biomedicines14061233 [doi] LID - 1233 AB - Organoids are three-dimensional culture systems that self-organize and partially recapitulate the architecture, cellular composition, and functional properties of native tissues. In pediatric congenital hepatobiliary diseases, persistent cholestasis, bile duct maldevelopment, epithelial injury, and progressive fibrosis often lead to cirrhosis, liver failure, or the necessity for liver transplantation. Compared with conventional two-dimensional cell culture and animal models, hepatobiliary organoids provide patient-derived, human-relevant platforms for modeling disease mechanisms, evaluating therapeutic responses, and exploring regenerative strategies. Unlike previous reviews that mainly discuss general organoid culture systems or broad liver disease modeling, this review is organized around clinically oriented translational endpoints, including mechanistic target discovery, prognostic stratification, therapeutic validation, and regenerative reconstruction. We further discuss current barriers to clinical translation, including reproducibility, scalability, vascularization, immune integration, manufacturing standardization, and patient-specific genetic, environmental, and dietary modifiers. By integrating disease-specific mechanisms with translational applications, this review provides a framework for understanding how organoid-based platforms may contribute to future diagnosis, risk assessment, therapeutic decision-making, and regenerative medicine in pediatric congenital hepatobiliary disorders. FAU - Zhang, Shanshan AU - Zhang S AUID- ORCID: 0009-0007-8447-5271 AD - Department of Pediatric Surgery, Shanghai Key Laboratory of Birth Defect, and Key Laboratory of Neonatal Disease, Ministry of Health, Children's Hospital of Fudan University, Shanghai 201102, China. FAU - Jiang, Jingying AU - Jiang J AD - Department of Pediatric Surgery, Shanghai Key Laboratory of Birth Defect, and Key Laboratory of Neonatal Disease, Ministry of Health, Children's Hospital of Fudan University, Shanghai 201102, China. FAU - Zheng, Shan AU - Zheng S AD - Department of Pediatric Surgery, Shanghai Key Laboratory of Birth Defect, and Key Laboratory of Neonatal Disease, Ministry of Health, Children's Hospital of Fudan University, Shanghai 201102, China. LA - eng GR - shslczdzk05703/Shanghai Public Health Clinical Center/ PT - Journal Article PT - Review DEP - 20260529 PL - Switzerland TA - Biomedicines JT - Biomedicines JID - 101691304 PMC - PMC13297528 OTO - NOTNLM OT - congenital hepatobiliary diseases OT - mechanisms and translation OT - organoids COIS- The authors declare no conflicts of interest. EDAT- 2026/06/26 06:40 MHDA- 2026/06/26 06:41 PMCR- 2026/05/29 CRDT- 2026/06/26 01:01 PHST- 2026/03/31 00:00 [received] PHST- 2026/05/14 00:00 [revised] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/06/26 06:41 [medline] PHST- 2026/06/26 06:40 [pubmed] PHST- 2026/06/26 01:01 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - biomedicines14061233 [pii] AID - biomedicines-14-01233 [pii] AID - 10.3390/biomedicines14061233 [doi] PST - epublish SO - Biomedicines. 2026 May 29;14(6):1233. doi: 10.3390/biomedicines14061233. PMID- 42351134 OWN - NLM STAT- MEDLINE DCOM- 20260927 LR - 20260930 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jun 25 TI - Dietary patterns and oral health practices among primary school children aged 6-15 years in urban informal settlements of Eldoret City, Kenya. LID - 10.1186/s12903-026-08778-6 [doi] LID - 1850 AB - BACKGROUND: Dental caries remains one of the most prevalent chronic conditions among school-aged children, disproportionately affecting those in informal settlements where dietary risks and preventive oral health services are limited. AIM: This study assessed dietary patterns, oral hygiene practices, and their association with dental caries among primary school children aged 6-15 years in informal settlements of Eldoret City in Uasin Gishu County, Kenya. METHODS: The study adopted a school-based cross-sectional design and involved 407 primary school children selected using proportionate stratified random sampling. Data was collected using a validated and pretested structured questionnaire, while clinical oral assessment was based on WHO field guidelines for the examination of dental caries. Data was analyzed using SPSS v.26. Chi-square tests assessed associations, and bivariate and multivariate logistic regression models were used to identify independent dietary patterns and oral hygiene practices associated with dental caries. RESULTS: Out of 407 children, 55.3% were females, and their average mean age was 12.15 +/- 2.98 years. The prevalence of dental caries was 26.0% (95% CI: 21.8-30.3). Daily consumption of sugary foods and beverages and suboptimal oral hygiene practices were relatively high. Multivariate logistic regression models revealed daily intake of biscuits, cakes, sweet pies, and buns (AOR = 2.31; 95% CI: 1.36-3.74; p = 0.004), daily consumption of sweets and candy (AOR = 2.42; 95% CI: 1.35-3.91; p = 0.006), brushing less than twice daily (AOR = 2.92; 95% CI: 1.18-3.87; p = 0.023), and not using fluoride toothpaste (AOR = 1.83; 95% CI: 1.12-2.61; p = 0.043) were independently associated with higher odds of dental caries among primary school children. CONCLUSION: Integrated school- and community-based prevention strategies targeting dietary patterns and oral hygiene promotion are urgently needed to reduce preventable oral health inequities among vulnerable schoolchildren. CI - (c) 2026. The Author(s). FAU - Wandia, Florence AU - Wandia F AD - School of Health Sciences, University of Kabianga, Kericho, Kericho County, Kenya. FAU - Wanzala, Joel AU - Wanzala J AD - School of Health Sciences, University of Kabianga, Kericho, Kericho County, Kenya. abbysansiojoel@gmail.com. LA - eng PT - Journal Article DEP - 20260625 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - Child MH - Female MH - Kenya/epidemiology MH - Male MH - Cross-Sectional Studies MH - Adolescent MH - *Dental Caries/epidemiology MH - *Oral Hygiene/statistics & numerical data MH - *Feeding Behavior MH - *Diet/statistics & numerical data MH - Prevalence MH - *Oral Health MH - Toothbrushing/statistics & numerical data MH - Urban Population MH - Fluoride Treatment PMC - PMC13617819 OTO - NOTNLM OT - Dental caries OT - Dietary patterns OT - Informal settlement OT - Kenya OT - Oral health practices OT - School children COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Institutional Scientific Ethics Review Committee (ISERC) of the University of Eastern Africa Baraton (UEAB/ISERC/05/02/2025). The study received a research permit/license for the National Commission for Science, Technology and Innovation (NACOSTI/P/25/4175815). Additionally, permission was sought from the Ministry of Education and selected primary school administration. Informed consent was obtained from the parents or legal guardians of all the participants, as they aged 15 years and below. Researchers explained the aim, benefits, duration, and the activities that the study involved to parents and guardians. Participation was voluntary, and participants were informed that they could withdraw from the study at any time without consequences. Confidentiality and privacy were maintained by using anonymized data and private interviews. Additionally, the study adhered to the principles of the Declaration of Helsinki on ethical research involving human participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/26 00:50 MHDA- 2026/09/28 05:33 PMCR- 2026/06/25 CRDT- 2026/06/25 23:59 PHST- 2026/02/20 00:00 [received] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/09/28 05:33 [medline] PHST- 2026/06/26 00:50 [pubmed] PHST- 2026/06/25 23:59 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1186/s12903-026-08778-6 [pii] AID - 8778 [pii] AID - 10.1186/s12903-026-08778-6 [doi] PST - epublish SO - BMC Oral Health. 2026 Jun 25;26(1):1850. doi: 10.1186/s12903-026-08778-6. PMID- 42351094 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260918 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 25 TI - Strengthening cancer prevention in european schools: a randomized controlled trial of digital interventions in adolescents: the SUNRISE program. LID - 10.1186/s12889-026-28185-4 [doi] LID - 2558 AB - BACKGROUND: Cancer remains a leading cause of mortality worldwide, with a substantial proportion of cases attributable to modifiable lifestyle-related risk factors that emerge during adolescence and often persist into adulthood. Despite the importance of this developmental period for habit formation, evidence on scalable, theory-driven, and sustainable school-based prevention interventions remains limited. The SUNRISE project addresses this gap by evaluating a co-created, digitally supported life-skills programme designed for routine school settings. METHODS: SUNRISE is a pragmatic, multinational, cluster randomised controlled trial conducted in approximately 80 primary and secondary schools across eight European countries (Greece, Switzerland, Slovenia, Spain, Cyprus, Italy, Belgium, and Romania), recruiting around 4,000 students. Classes are randomised at the class level (3:1) to either a six-month digitally enhanced life-skills intervention or standard education. The primary aim of the study is to evaluate the feasibility, implementation, and sustainability of the intervention in real-world school settings, with secondary exploratory assessment of behavioural outcomes. The intervention integrates multiple digital components, including a mobile-based life-skills coaching programme, a conversational assistant, educational and serious games, influencer-led media literacy content, moderated social interaction platforms, and teacher-led educational modules. Intervention design is guided by the Capability-Opportunity-Motivation Behaviour (COM-B) model and developed through systematic co-creation with students, educators, parents, public health experts, and policymakers within a School Living Lab framework. Feasibility, implementation, and sustainability are evaluated using the RE-AIM and PRISM frameworks. Secondary behavioural outcomes include substance use, dietary and physical activity behaviours, mental well-being, stress, social skills, critical thinking towards media and advertising, and critical coping with food-related information, assessed at baseline, 6 months, and 18 months. DISCUSSION: SUNRISE integrates behavioural science, participatory design, and digital innovation to address adolescent health behaviours in real-world educational contexts. By embedding implementation and sustainability evaluation alongside behavioural outcomes, the study aims to generate actionable evidence on how multi-component digital interventions can be adopted, adapted, and maintained across diverse school systems. Findings are expected to inform future large-scale, theory-driven, equitable, and sustainable cancer prevention strategies targeting adolescents across Europe. TRIAL REGISTRATION: NCT06931847 (registration date: 2025-04-09). CI - (c) 2026. The Author(s). FAU - Barasoain, Maitane AU - Barasoain M AUID- ORCID: 0000-0002-9142-4161 AD - Biobizkaia Health Research Institute, Plaza Cruces 12, Barakaldo, Bizkaia, 48903, Spain. FAU - Velez-Del-Burgo, Ainara AU - Velez-Del-Burgo A AUID- ORCID: 0000-0002-1283-2336 AD - Biobizkaia Health Research Institute, Plaza Cruces 12, Barakaldo, Bizkaia, 48903, Spain. FAU - Astigarraga, Itziar AU - Astigarraga I AUID- ORCID: 0000-0002-5012-0137 AD - Cruces University Hospital, Osakidetza, Barakaldo, Bizkaia, Spain. FAU - Haug, Severin AU - Haug S AUID- ORCID: 0000-0002-6539-5045 AD - Swiss Research Institute for Public Health and Addiction ISGF, University of Zurich, Zurich, Switzerland. FAU - Kiselev, Nikolai AU - Kiselev N AUID- ORCID: 0000-0003-0617-0353 AD - Swiss Research Institute for Public Health and Addiction ISGF, University of Zurich, Zurich, Switzerland. FAU - Koutra, Kleio AU - Koutra K AUID- ORCID: 0000-0001-9713-5013 AD - Department of Social Work, Social Applied Research and Social Work Lab, Hellenic Mediterranean University, Chania, Greece. FAU - Kilintzis, Vassilis AU - Kilintzis V AUID- ORCID: 0000-0002-9783-6757 AD - BMI Lab, ECE-HMU & CBML, FORTH-ICS, Thessaloniki, Greece. FAU - Krini, Maria AU - Krini M AUID- ORCID: 0000-0001-8122-963X AD - Pagkyprios Syndesmos Karkinopathon Kai Filon 1986 (PASYKAF), Department of Research and Development, Nicosia, Cyprus. FAU - Pampaka, Theophano AU - Pampaka T AD - Pagkyprios Syndesmos Karkinopathon Kai Filon 1986 (PASYKAF), Department of Research and Development, Nicosia, Cyprus. FAU - Hudders, Liselot AU - Hudders L AUID- ORCID: 0000-0002-9585-7175 AD - Dept. of Communication Sciences, Center for Persuasive Communication, Ghent University, Ghent, Belgium. FAU - De Keyzer, Eline AU - De Keyzer E AUID- ORCID: 0009-0003-9321-0516 AD - Dept. of Communication Sciences, Center for Persuasive Communication, Ghent University, Ghent, Belgium. FAU - Serrano, Polonca AU - Serrano P AUID- ORCID: 0000-0002-5240-7748 AD - Alma Mater Europaea University, Maribor, Slovenia. FAU - Pilotti, Chiara AU - Pilotti C AD - FAVO ETS ODV, Federazione Italiana delle Associazioni di Volontariato in Oncologia ETS - Organizzazione di Volontariato, Rome, Italy. FAU - Del Campo, Laura AU - Del Campo L AD - FAVO ETS ODV, Federazione Italiana delle Associazioni di Volontariato in Oncologia ETS - Organizzazione di Volontariato, Rome, Italy. FAU - Nicoara, Delia AU - Nicoara D AUID- ORCID: 0000-0003-1010-3049 AD - Institute of Oncology Prof. Dr. Ion Chiricuta: Cluj-Napoca, Cluj-Napoca County, Romania. FAU - Nicoara, Niculina AU - Nicoara N AUID- ORCID: 0009-0008-7642-165X AD - Institute of Oncology Prof. Dr. Ion Chiricuta: Cluj-Napoca, Cluj-Napoca County, Romania. FAU - Molina-Barcelo, Ana AU - Molina-Barcelo A AUID- ORCID: 0000-0001-5113-6475 AD - Cancer and Public Health Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, Valencia, Spain. FAU - de Pablo Pardo, Teresa AU - de Pablo Pardo T AUID- ORCID: 0009-0004-7878-9643 AD - Cancer and Public Health Research Unit, Foundation for the Promotion of Health and Biomedical Research in the Valencian Region, Valencia, Spain. FAU - Verduyn, Stefanie AU - Verduyn S AD - GEZOND, Flemish Institute for Healthy Living, Brussels, Belgium. FAU - Cea, Gloria AU - Cea G AUID- ORCID: 0000-0002-6947-4672 AD - BRIDG OU, Tallinn, Estonia. FAU - Katsapi, Chrysoula AU - Katsapi C AUID- ORCID: 0000-0002-3538-0432 AD - Department of Social Work, Social Applied Research and Social Work Lab, Hellenic Mediterranean University, Chania, Greece. FAU - Segal, Lucas Javier AU - Segal LJ AUID- ORCID: 0009-0005-5544-2994 AD - PredictBy Research and Consulting, Barcelona, Spain. FAU - Tsoupouroglou, Iraklis AU - Tsoupouroglou I AUID- ORCID: 0000-0003-4666-1237 AD - Lab of Medical Physics and Digital Innovation, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Guerra, Barbara AU - Guerra B AUID- ORCID: 0000-0003-3389-1973 AD - PARTICLE Summary, Lisbon, Portugal. FAU - Triantafyllidis, Andreas AU - Triantafyllidis A AUID- ORCID: 0000-0002-6938-8256 AD - Information Technologies Institute, Centre for Research and Technology Hellas, Thessaloniki, Greece. FAU - Arana-Arri, Eunate AU - Arana-Arri E AUID- ORCID: 0000-0001-9759-333X AD - Biobizkaia Health Research Institute, Plaza Cruces 12, Barakaldo, Bizkaia, 48903, Spain. eunate.aranaarri@osakidetza.eus. AD - Cruces University Hospital, Osakidetza, Barakaldo, Bizkaia, Spain. eunate.aranaarri@osakidetza.eus. CN - SUNRISE Study Group LA - eng SI - ClinicalTrials.gov/NCT06931847 PT - Journal Article PT - Multicenter Study PT - Pragmatic Clinical Trial PT - Randomized Controlled Trial DEP - 20260625 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - Europe MH - *Health Promotion/methods MH - *Neoplasms/prevention & control MH - Program Evaluation MH - *School Health Services/organization & administration MH - Schools PMC - PMC13555859 OTO - NOTNLM OT - Adolescent health OT - Cancer prevention OT - Cluster randomised controlled trial OT - Digital health intervention OT - Health promotion OT - Implementation science OT - Life skills OT - School-based intervention COIS- Declarations. Ethics approval and consent to participate: All procedures performed in the study adhered to the ethical standards of the institutional research Ethics Committee of each Country and the 1964 Declaration of Helsinki and its subsequent amendments. This article does not contain any studies with animals performed by any authors. Consent to participate will be obtained from patients before their involvement in the study. Age-appropriate participant information sheets and consent/assent forms for different age groups, as well as for parents or legal guardians, are provided in Supplementary Material (Supplementary File 5). The protocol has been approved by the local clinical research ethics committees. Details of ethics approvals, including approval reference numbers, are provided in Supplementary Material (Supplementary File 4). Consent for publication: Not applicable. Competing interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. FIR - Segkouli, Sofia IR - Segkouli S FIR - Laloumis, Nikos IR - Laloumis N FIR - Alexiadis, Anastasios IR - Alexiadis A FIR - Lithoxoidou, Evdoxia-Eirini IR - Lithoxoidou EE FIR - Spirou, Aggeliki IR - Spirou A FIR - Georgiadis, Charalabos IR - Georgiadis C FIR - Kafetzopoulos, Sotirios IR - Kafetzopoulos S FIR - Votis, Konstantinos IR - Votis K FIR - Tzovaras, Dimitrios IR - Tzovaras D FIR - Kondylakis, Haridimos IR - Kondylakis H FIR - Lina, Pelekidou IR - Lina P FIR - Pityanou, Konstantina IR - Pityanou K FIR - Micheli, Katerina IR - Micheli K FIR - Samara, Rafaela IR - Samara R FIR - Konstantinidis, Theocharis IR - Konstantinidis T FIR - Maniadi, Evaggelia IR - Maniadi E FIR - Markakis, Evangelos IR - Markakis E FIR - Tziraki, Charikleia IR - Tziraki C FIR - Marias, Kostas IR - Marias K FIR - Tsiknakis, Emmanouil IR - Tsiknakis E FIR - Philippou, Nicolas IR - Philippou N FIR - Xydia, Stavri IR - Xydia S FIR - Ferentinou, Marisa IR - Ferentinou M FIR - DeJans, Steffi IR - DeJans S FIR - Van de Sompel, Dieneke IR - Van de Sompel D FIR - Beuckels, Emma IR - Beuckels E FIR - Pearce, Hayley IR - Pearce H FIR - Schreiner, Tania IR - Schreiner T FIR - Albert, Yvette IR - Albert Y FIR - Bogataj, David IR - Bogataj D FIR - Inkret, Anja IR - Inkret A FIR - Goswami, Nandu IR - Goswami N FIR - Bamidis, Panagiotis IR - Bamidis P FIR - Reppou, Sofia IR - Reppou S FIR - Spachos, Dimitrios IR - Spachos D FIR - Gallego, Alba IR - Gallego A FIR - Mallo, Irene IR - Mallo I FIR - Buhid, Eduardo IR - Buhid E FIR - Fico, Giuseppe IR - Fico G FIR - Cabrera, Maria Fernanda IR - Cabrera MF FIR - Villanueva, Francisco Lupianez IR - Villanueva FL FIR - Van der Feen, Justine IR - Van der Feen J FIR - Dietrich, Nick IR - Dietrich N FIR - Roca-Umbert, Ana IR - Roca-Umbert A FIR - Manso, Marco IR - Manso M FIR - Pires, Jose IR - Pires J FIR - Vanaclocha, Mercedes IR - Vanaclocha M FIR - Romeo, Paula IR - Romeo P FIR - Manyogil, Belen IR - Manyogil B FIR - Gandia, Mireia IR - Gandia M FIR - Garcia, Oscar IR - Garcia O FIR - Marulanda, Erika IR - Marulanda E FIR - Valentinotti, Rachele IR - Valentinotti R FIR - Iannelli, Elisabetta IR - Iannelli E FIR - De Lorenzo, Francesco IR - De Lorenzo F FIR - De Persis, Davide IR - De Persis D FIR - Summa, Alice IR - Summa A FIR - Sanchez Perez, Alvaro IR - Sanchez Perez A FIR - Peiro Callizo, Enrique IR - Peiro Callizo E FIR - Orcajo-Lago, Janire IR - Orcajo-Lago J FIR - Meijide, Susana IR - Meijide S FIR - Idoyaga-Uribbarrena, Jon Eneko IR - Idoyaga-Uribbarrena JE FIR - Gomez-Sanchez, Veronica IR - Gomez-Sanchez V FIR - Martin-Rodriguez, Haizea IR - Martin-Rodriguez H FIR - de Bareno, Macarena IR - de Bareno M FIR - Llarena, Marta IR - Llarena M FIR - Liakopoulos, Vassilis IR - Liakopoulos V FIR - Panagopoulou, Maria IR - Panagopoulou M FIR - Mavromanolakis, Giorgos IR - Mavromanolakis G FIR - Manteli, Maria IR - Manteli M FIR - Koulouris, Pavlos IR - Koulouris P FIR - Sotiriou, Sofoklis IR - Sotiriou S FIR - Neven, Loes IR - Neven L FIR - Rizvi, Katie IR - Rizvi K FIR - Rusu, Oana IR - Rusu O FIR - Todea, Diana IR - Todea D FIR - Cristea, Laura IR - Cristea L FIR - Trifulescu, Cristina IR - Trifulescu C FIR - Wenger, Andreas IR - Wenger A FIR - Boumparis, Niko IR - Boumparis N FIR - Studhalter, Olivia IR - Studhalter O FIR - Champion, Katrina IR - Champion K FIR - Teesson, Maree IR - Teesson M FIR - Newton, Nicola IR - Newton N EDAT- 2026/06/26 04:10 MHDA- 2026/09/09 07:07 PMCR- 2026/06/25 CRDT- 2026/06/25 23:58 PHST- 2026/01/31 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/09/09 07:07 [medline] PHST- 2026/06/26 04:10 [pubmed] PHST- 2026/06/25 23:58 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1186/s12889-026-28185-4 [pii] AID - 28185 [pii] AID - 10.1186/s12889-026-28185-4 [doi] PST - epublish SO - BMC Public Health. 2026 Jun 25;26(1):2558. doi: 10.1186/s12889-026-28185-4. PMID- 42351021 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260813 IS - 1471-2369 (Electronic) IS - 1471-2369 (Linking) VI - 27 IP - 1 DP - 2026 Jun 25 TI - Screening for urinary abnormalities in healthy school children living in an African urban megacity. LID - 10.1186/s12882-026-05151-1 [doi] LID - 391 AB - BACKGROUND: Urinary screening is a useful and non-invasive tool for identifying occult kidney disease in asymptomatic children and may be an important initial step in preventing progressive kidney disease. However, this screening is not commonly performed in children living in low-resource countries, including the Democratic Republic of the Congo (DRC). This study aimed to determine the prevalence of albuminuria and its associated factors among healthy school children living in DRC. In addition, the study examined the prevalence of urinary abnormalities detected by dipstick in this population. METHODS: This cross-sectional study was conducted in 17 schools in Kinshasa. A multistage sampling procedure was applied, and 497 healthy school children aged 6 to 16 were randomly recruited. Anthropometric and clinical data were collected. Using a single-sample measurement, urinary albumin-to-creatinine ratio (ACR) was determined by an immunoturbidimetric method, and dipstick tests were performed to detect other urinary abnormalities (leukocyturia, nitrituria, proteinuria, hematuria). Albuminuria was defined as ACR >/= 30 mg/g. Logistic regression was used to identify clinical factors associated with albuminuria. RESULTS: Among the 497 school children (208 boys and 289 girls), 58 had single-sample albuminuria, corresponding to a prevalence of 11.7%. There was no significant association between albuminuria and clinical variables based on univariate logistic regression analysis. Dipstick urinary abnormalities were present in 113 children (22.7%). Specifically, leukocyturia, nitrituria, proteinuria, and hematuria were detected in 14.3%, 1.6%, 8.2%, and 1.6% of participants, respectively. Leukocyturia and nitrituria were significantly more common among girls (p < 0.001). CONCLUSION: Urinary abnormalities are common among asymptomatic school children in the DRC. Although a single measurement was performed, these results raise the relevant question of the usefulness of urinary screening in children living in resource-limited settings. However, the feasibility, cost, and potential benefits of such a program warrant further evaluation in these settings. CI - (c) 2026. The Author(s). FAU - Nkoy, Agathe Bikupe AU - Nkoy AB AUID- ORCID: 0000-0002-1563-380X AD - Division of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo. agath.nkoy@gmail.com. FAU - Matoka, Therance Tobo AU - Matoka TT AD - Division of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo. FAU - Minimbu, Orielle Mafuta AU - Minimbu OM AD - Division of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo. FAU - Odio, Bienvenu Matondo AU - Odio BM AD - Division of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo. FAU - Levtchenko, Elena AU - Levtchenko E AD - Department of Pediatric Nephrology, Amsterdam University Medical Centers, Amsterdam, The Netherlands. FAU - Ekulu, Pepe Mfutu AU - Ekulu PM AD - Division of Nephrology, Department of Pediatrics, University Hospital of Kinshasa, University of Kinshasa, Kinshasa, Democratic Republic of Congo. LA - eng PT - Journal Article DEP - 20260625 PL - England TA - BMC Nephrol JT - BMC nephrology JID - 100967793 SB - IM MH - Humans MH - Female MH - Child MH - Male MH - Cross-Sectional Studies MH - *Albuminuria/epidemiology/diagnosis/urine MH - Democratic Republic of the Congo/epidemiology MH - *Mass Screening/methods MH - Adolescent MH - Prevalence MH - *Urban Population MH - Urinalysis MH - Proteinuria/epidemiology/diagnosis PMC - PMC13317383 OTO - NOTNLM OT - African children OT - Albuminuria OT - Dipstick OT - Proteinuria OT - Screening COIS- Declarations. Ethical approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki, approved by the National Ethics Committee of the Kinshasa School of Public Health (ESP/CE/256/2019) and was authorized by the relevant administrative and school authorities. Written informed consent was obtained from parents or legal guardians of children before the recruitment. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/26 00:42 MHDA- 2026/06/30 06:31 PMCR- 2026/06/25 CRDT- 2026/06/25 23:56 PHST- 2026/02/08 00:00 [received] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/06/30 06:31 [medline] PHST- 2026/06/26 00:42 [pubmed] PHST- 2026/06/25 23:56 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1186/s12882-026-05151-1 [pii] AID - 5151 [pii] AID - 10.1186/s12882-026-05151-1 [doi] PST - epublish SO - BMC Nephrol. 2026 Jun 25;27(1):391. doi: 10.1186/s12882-026-05151-1. PMID- 42351010 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260916 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 25 TI - Breaking down breakfast: the relationship between morning meals and learning difficulties in adolescents. LID - 10.1186/s12887-026-07085-x [doi] LID - 856 AB - BACKGROUND: Learning difficulties (LDs) impair academic performance and cognitive function. Dietary factors, particularly the composition of breakfast, may influence LDs. OBJECTIVE: To examine the association between breakfast composition and LDs in adolescents. METHODS: A cross-sectional study was conducted among 501 adolescents aged 10-19 from four schools in Jahrom, Iran. Trained dietitians collected dietary data using three non-consecutive 24-hour recalls (two on weekdays and one on a weekend). Weight and height were measured following a standardized protocol. Additionally, LDs were assessed using the validated Colorado Learning Difficulties Score (CLDS) questionnaire. Higher scores of CLDS reflect greater LDs. RESULTS: Using the CLDS, adolescents were classified into four equal quartiles. In all food group analyses, adolescents who consumed fewer than one serving/day were considered the reference group. Adolescents who consumed more than one serving of dairy had lower odds of being in the highest CLDS quartile (1-2 servings: OR 0.42; 95% CI 0.20-0.87; 3-4 servings: OR 0.19; 95% CI 0.07-0.47; >4 servings: OR 0.22; 95% CI 0.05-0.86). Furthermore, adolescents who consumed more than four servings of simple sugar had higher odds of being in the highest CLDS quartile (> 4 servings: OR 3.60; 95% CI 1.09-11.8). CONCLUSION: Our findings suggest that higher dairy intake and lower consumption of simple sugar waere associated with lower odds of LDs in adolescents. Further longitudinal studies are warranted. CI - (c) 2026. The Author(s). FAU - Rahmanian, Reza AU - Rahmanian R AUID- ORCID: 0009-0004-0125-5096 AD - School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. AD - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Pirbasti, Ali Razeghi AU - Pirbasti AR AUID- ORCID: 0009-0003-7237-5784 AD - Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Shaygantabar, Mohsen AU - Shaygantabar M AUID- ORCID: 0009-0006-5483-9495 AD - Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Javaheri-Tafti, Fatemeh AU - Javaheri-Tafti F AUID- ORCID: 0009-0002-3299-2684 AD - Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Bahreini-Boroujeni, Leyli Zahra AU - Bahreini-Boroujeni LZ AUID- ORCID: 0009-0006-3898-051X AD - Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Hatami, Alireza AU - Hatami A AUID- ORCID: 0009-0001-8712-0165 AD - Department of Clinical Nutrition School of Nutrition and Food Science, Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. AD - Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Khoshrang, Andisheh AU - Khoshrang A AUID- ORCID: 0009-0009-3149-2873 AD - School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Sajedi, Leila AU - Sajedi L AUID- ORCID: 0009-0003-0330-7657 AD - Department of Education, Faculty of Teachers Education, Farhangian University, Shiraz, Iran. FAU - Ajami, Marjan AU - Ajami M AUID- ORCID: 0000-0002-6820-550X AD - Department of Food and Nutrition Policy and Planning Research, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Esmaili, Mina AU - Esmaili M AUID- ORCID: 0000-0002-8422-7864 AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Houshiarrad, Anahita AU - Houshiarrad A AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran. anahrad@yahoo.com. FAU - Doaei, Saeid AU - Doaei S AUID- ORCID: 0000-0002-2532-7478 AD - Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, P.O. Box 19395-4741, Iran. Sdoaei@sbmu.ac.ir. AD - Unit of Nutrition and Cancer, Cancer Epidemiology Research Program Catalan Institute of Oncology, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain. Sdoaei@sbmu.ac.ir. LA - eng PT - Journal Article DEP - 20260625 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Adolescent MH - *Learning Disabilities/etiology/epidemiology MH - Cross-Sectional Studies MH - *Breakfast/psychology MH - Child MH - Female MH - Male MH - Iran MH - *Feeding Behavior PMC - PMC13560118 OTO - NOTNLM OT - Breakfast OT - Cognitive function OT - Diary intake OT - Learning disabilities COIS- Declarations. Ethics approval and consent to participate: The research received approval from the Ethics Committee of the National Nutrition and Food Technology Research Institute at Shahid Beheshti University of Medical Sciences, Iran (IR.SBMU.NNFTRI.REC.1402.052). The study adheres to the principles outlined in the Declaration of Helsinki. All participants provided written informed consent before participating in this study. All personal information about participants will be kept secure in a database. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/26 00:51 MHDA- 2026/09/10 05:36 PMCR- 2026/06/25 CRDT- 2026/06/25 23:55 PHST- 2025/11/26 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/09/10 05:36 [medline] PHST- 2026/06/26 00:51 [pubmed] PHST- 2026/06/25 23:55 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1186/s12887-026-07085-x [pii] AID - 7085 [pii] AID - 10.1186/s12887-026-07085-x [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 25;26(1):856. doi: 10.1186/s12887-026-07085-x. PMID- 42351008 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260916 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 25 TI - Reclassification of SGA and EUGR in very preterm infants after the introduction of Fenton-2025: a retrospective cohort comparison with INTERGROWTH-21st and Fenton-2013. LID - 10.1186/s12887-026-07215-5 [doi] LID - 855 AB - BACKGROUND: In very preterm infants, the classification of small for gestational age (SGA) and extrauterine growth restriction (EUGR) depends on the growth chart used. In this context, the classification implications of the newly introduced Fenton-2025 curves have not yet been evaluated in this population. We compared SGA and EUGR classification across Fenton-2025, INTERGROWTH-21st, and Fenton-2013, and examined chart-specific associations between EUGR and major neonatal morbidities. METHODS: This retrospective single-centre cohort study included 272 infants born at 24-32 weeks' gestation. SGA was defined as birth weight below the 10th percentile. EUGR was defined as discharge weight-for-age Z score below - 2. Associations between chart-defined EUGR and neonatal morbidities were examined using multivariable logistic regression adjusted for gestational age, birth weight, and sex. RESULTS: SGA rates differed in rank order across the three charts, being lowest with Fenton-2013 (9.9%), intermediate with INTERGROWTH-21st (15.8%), and highest with Fenton-2025 (24.3%). For EUGR, the ordering was different: rates were lowest with INTERGROWTH-21st (26.1%), intermediate with Fenton-2013 (33.5%), and highest with Fenton-2025 (40.8%). Despite this difference in rank order, the three charts showed a nested classification pattern. Compared with INTERGROWTH-21st, Fenton-2025 classified 56% more infants (n = 40) as EUGR. Nevertheless, in adjusted analyses, infants classified as EUGR according to the Fenton 2013 and INTERGROWTH-21st charts were associated with higher adjusted odds (aOR 6.37, 95% CI 2.07-19.57, and aOR 5.03, 95% CI 1.82-13.90, respectively) of necrotising enterocolitis (>/= stage II) compared to non-EUGR infants, and this higher adjusted odds persisted after reclassification using the Fenton 2025 chart (aOR 4.96, 95% CI 1.68-14.64). CONCLUSIONS: Fenton-2025 applies a more inclusionary approach in classifying very preterm infants as SGA and EUGR compared with INTERGROWTH-21st and Fenton-2013. The clinical implications of this broader classification require further outcome-linked validation. CI - (c) 2026. The Author(s). FAU - Gur, Kutlay AU - Gur K AUID- ORCID: 0000-0001-6444-8101 AD - Department of Pediatrics, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, University of Health Sciences Turkiye, Istanbul, 34668, Turkiye. kutlaygur@gmail.com. FAU - Topcuoglu, Sevilay AU - Topcuoglu S AUID- ORCID: 0000-0002-1117-196X AD - Division of Neonatology, Department of Pediatrics, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, University of Health Sciences Turkiye, Istanbul, Turkiye. FAU - Dincer, Emre AU - Dincer E AUID- ORCID: 0000-0003-1429-3206 AD - Division of Neonatology, Department of Pediatrics, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, University of Health Sciences Turkiye, Istanbul, Turkiye. FAU - Ozalkaya, Elif AU - Ozalkaya E AUID- ORCID: 0000-0002-0992-1493 AD - Division of Neonatology, Department of Pediatrics, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, University of Health Sciences Turkiye, Istanbul, Turkiye. FAU - Karatekin, Guner AU - Karatekin G AUID- ORCID: 0000-0001-7112-0323 AD - Division of Neonatology, Department of Pediatrics, Zeynep Kamil Women and Children's Diseases Training and Research Hospital, University of Health Sciences Turkiye, Istanbul, Turkiye. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260625 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Retrospective Studies MH - Infant, Newborn MH - *Infant, Small for Gestational Age/growth & development MH - Female MH - Male MH - *Growth Charts MH - *Fetal Growth Retardation/classification/diagnosis MH - *Infant, Premature/growth & development MH - Logistic Models MH - Gestational Age PMC - PMC13560381 OTO - NOTNLM OT - Extrauterine Growth Restriction OT - Fenton Growth Chart OT - Growth Charts OT - INTERGROWTH-21st OT - Infant, Very Premature OT - Small for Gestational Age COIS- Declarations. Ethics approval and consent to participate: Retrospective data collection was approved by the Clinical Research Ethics Committee of Zeynep Kamil Women and Children's Diseases Training and Research Hospital (Decision No. 93, Date: 21 April 2021). The updated Fenton-2025 reanalysis for the current manuscript was approved by the Zeynep Kamil Hospital Non-Interventional Research Ethics Committee (Decision No. 26, Date: 25 February 2026). The study was conducted in accordance with the Declaration of Helsinki. Owing to the retrospective nature of the updated reanalysis and the use of previously recorded hospital data, separate informed consent to participate was not required, as stated in the ethics application approved by the Zeynep Kamil Hospital Non-Interventional Research Ethics Committee. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/26 00:50 MHDA- 2026/09/10 05:36 PMCR- 2026/06/25 CRDT- 2026/06/25 23:55 PHST- 2026/04/22 00:00 [received] PHST- 2026/06/18 00:00 [accepted] PHST- 2026/09/10 05:36 [medline] PHST- 2026/06/26 00:50 [pubmed] PHST- 2026/06/25 23:55 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1186/s12887-026-07215-5 [pii] AID - 7215 [pii] AID - 10.1186/s12887-026-07215-5 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 25;26(1):855. doi: 10.1186/s12887-026-07215-5. PMID- 42350907 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260625 IS - 1742-7843 (Electronic) IS - 1742-7835 (Linking) VI - 139 IP - 2 DP - 2026 Aug TI - Association Between Urinary Heavy Metals and Developmental Disorders in Children Aged 6-15 Years: A Study Based on the NHANES Database. PG - e70266 LID - 10.1111/bcpt.70266 [doi] AB - This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) collected between 1999 and 2018, enrolling a total of 4525 children and adolescents aged 6-15 years. Weighted logistic regression, weighted quantile sum (WQS) regression and quantile g-computation (qgcomp) models were applied to explore the associations between nine urinary heavy metals (UHMs) and developmental disorders (DDs). After full covariate adjustment, urinary lead (Pb) (OR = 1.30, 95% CI: 1.10-1.54) and urinary antimony (Sb) (OR = 1.41, 95% CI: 1.18-1.69) were found to be positively correlated with DDs. Combined exposure models further identified a positive joint relationship between the mixture of UHMs and DDs, with Pb and Sb serving as the major contributing components. Sensitivity analyses that defined DDs solely based on receipt of special education or early intervention services yielded consistent findings. Given the limitations inherent to the cross-sectional design, single-spot urine sampling and heterogeneous outcome definitions, the present findings can only demonstrate correlational relationships, and further longitudinal investigations are required for conclusive validation. CI - (c) 2026 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). Published by John Wiley & Sons Ltd. FAU - Liao, Yanping AU - Liao Y AD - Department of Pediatrics, Longyan First Hospital of Fujian Medical University, Longyan, Fujian, China. FAU - Zhan, Lingling AU - Zhan L AD - Department of Pediatrics, Longyan First Hospital of Fujian Medical University, Longyan, Fujian, China. FAU - Li, Hong AU - Li H AUID- ORCID: 0009-0004-1125-7079 AD - Department of Pediatrics, Longyan First Hospital of Fujian Medical University, Longyan, Fujian, China. LA - eng PT - Journal Article PL - England TA - Basic Clin Pharmacol Toxicol JT - Basic & clinical pharmacology & toxicology JID - 101208422 RN - 0 (Metals, Heavy) RN - 2P299V784P (Lead) RN - 0 (Environmental Pollutants) SB - IM MH - Humans MH - Child MH - Cross-Sectional Studies MH - *Metals, Heavy/urine MH - Adolescent MH - Nutrition Surveys MH - Female MH - Male MH - *Developmental Disabilities/urine/epidemiology MH - United States/epidemiology MH - *Environmental Exposure/adverse effects/analysis MH - Lead/urine MH - Databases, Factual MH - *Environmental Pollutants/urine OAB - Exposure to heavy metals may raise the risk of developmental disorders (DDs) in children. This study analysed urine samples from over 4500 US children aged 6-15 for nine metals. Higher levels of lead and antimony were linked to greater odds of having a DD. When considering all metals together, lead and antimony were the main drivers of increased risk. The link with lead was stronger in boys, while antimony affected both boys and girls. Reducing exposure to these metals could help prevent DDs, especially in vulnerable groups like boys. OABL- eng OTO - NOTNLM OT - NHANES OT - children OT - developmental disorders OT - urinary heavy metals EDAT- 2026/06/26 00:47 MHDA- 2026/06/27 04:10 CRDT- 2026/06/25 23:34 PHST- 2026/06/10 00:00 [revised] PHST- 2026/03/20 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/26 00:47 [pubmed] PHST- 2026/06/25 23:34 [entrez] AID - 10.1111/bcpt.70266 [doi] PST - ppublish SO - Basic Clin Pharmacol Toxicol. 2026 Aug;139(2):e70266. doi: 10.1111/bcpt.70266. PMID- 42350848 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1865-5785 (Electronic) IS - 1868-9256 (Print) IS - 1865-5785 (Linking) VI - 19 IP - 1 DP - 2026 Jun 25 TI - Diagnostic potential of Q-flags (RBC agglutination? and fragments?) in beta thalassemia carriers: a comparative analysis with nutritional anemias. LID - 10.1007/s12308-026-00710-9 [doi] LID - 35 AB - INTRODUCTION: Beta thalassemia carriers have hereditary anemia marked by ineffective erythropoiesis and hemolysis, leading to considerable variation in red blood cell (RBC) morphology. Automated hematology analyzers equipped with quality flags (Q-flags) can identify abnormal RBC populations. This study evaluates the diagnostic performance of two Q-flags (RBC Agglutination? and Fragments?) in differentiating beta thalassemia from common nutritional anemias. METHODS: This study was conducted on complete blood count (CBC) data from 37 patients with beta thalassemia carriers and 3317 patients with nutritional anemias, including 2780 with iron deficiency anemia, 478 with vitamin B12 deficiency, and 59 with folate deficiency. All data were obtained using Sysmex hematology analyzers. The Shapiro-Wilk test assessed the distribution of data, and group comparisons were performed using the Mann-Whitney U test. Receiver operating characteristic (ROC) curve analysis was employed to determine the cutoff values of Q-flag parameters. RESULTS: Patients with beta thalassemia demonstrated significantly lower values for Q-flag (RBC Agglutination?) and significantly higher values for Q-flag (Fragments?) compared to those with nutritional anemias. The median (interquartile range) for Q-flag (RBC Agglutination?) was 40.0 (40.0-50.0), and for Q-flag (Fragments?) it was 40.0 (20.0-60.0). Significant differences were also noted in routinely reported hematological indices such as MCV, MCH, MCHC, and MicroR%. ROC analysis revealed that cutoff value of 60.0 for Q-flag (RBC Agglutination?) and 20.0 for Q-flag (Fragments?) had reasonable sensitivity and specificity for distinguishing beta thalassemia from nutritional anemias. CONCLUSION: There is a possibility that both Q-flags demonstrate strong discriminatory ability for beta thalassemia carriers in comparison to nutritional anemias and serve as useful screening tools within routine hematology workflows. CI - (c) 2026. The Author(s). FAU - Shaikh, Muhammad Shariq AU - Shaikh MS AUID- ORCID: 0000-0003-2938-7416 AD - Section of Hematology & Transfusion Medicine, Department of Pathology and Laboratory Medicine, The Aga Khan University Hospital, Stadium Road, Karachi, 74800, Pakistan. muhammad.shariq@aku.edu. FAU - Nunes, Joao Marcelo Martins AU - Nunes JMM AD - Sysmex Asia Pacific, R & D Centre, 9 Tampines Grande, Asia Green, #06-18, Singapore, 528735, Singapore. FAU - Kono, Mari AU - Kono M AD - Sysmex Asia Pacific, R & D Centre, 9 Tampines Grande, Asia Green, #06-18, Singapore, 528735, Singapore. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260625 PL - Germany TA - J Hematop JT - Journal of hematopathology JID - 101491976 SB - IM MH - Humans MH - *beta-Thalassemia/blood/diagnosis/genetics MH - Female MH - Male MH - Adult MH - Adolescent MH - Anemia, Iron-Deficiency/blood/diagnosis MH - Heterozygote MH - *Erythrocytes, Abnormal/pathology MH - *Anemia/diagnosis/blood MH - Young Adult MH - Child PMC - PMC13303572 OTO - NOTNLM OT - Anemia diagnostics OT - Beta thalassemia carrier OT - Hematology analyzer flagging OT - RBC variation COIS- Declarations. Ethical approval: This study used anonymized laboratory data obtained from routine clinical testing. In accordance with institutional policy, ethical approvals and exemptions were obtained from the Aga Khan University Ethical Review Committee (AKU ERC #2024-9824-29,527) and the Sysmex Ethics Review Committee (Sysmex ERC #2024-025). In addition, approval was granted by the Research Ethics Committee of the National Bioethics Committee for Research, National Institute of Health (Ref No. 4-87/NBC-1138/23/471) for retrospective analyses not involving patient contact or identifiable information. Informed consent: Not applicable. Consent for publication: Not applicable. Conflict of interest: Joao Marcelo Martins Nunes and Mari Kono are employed in Sysmex group. EDAT- 2026/06/26 00:44 MHDA- 2026/06/27 04:10 PMCR- 2026/06/25 CRDT- 2026/06/25 23:32 PHST- 2025/12/10 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2026/06/26 00:44 [pubmed] PHST- 2026/06/25 23:32 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1007/s12308-026-00710-9 [pii] AID - 710 [pii] AID - 10.1007/s12308-026-00710-9 [doi] PST - epublish SO - J Hematop. 2026 Jun 25;19(1):35. doi: 10.1007/s12308-026-00710-9. PMID- 42349796 OWN - NLM STAT- MEDLINE DCOM- 20260807 LR - 20260807 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 226 DP - 2026 Nov 1 TI - Why we eat: Development and validation of a 7-factor Motivations for Eating Profile (MEP-7). PG - 108699 LID - S0195-6663(26)00261-8 [pii] LID - 10.1016/j.appet.2026.108699 [doi] AB - Understanding why people eat is crucial for the prevention and management of overeating and obesity, but existing psychometric tools typically assess a narrow set of motivational constructs. The current study developed a comprehensive, theory-driven questionnaire from a recently validated framework of eating behaviour traits derived from 18 existing eating behaviour scales and evaluated its psychometric properties and external validity. Study 1 used a structured review panel of n = 30 adults and applied item response theory to a survey of n = 1279 adults, to select items from widely used eating behaviour scales and novel items for 'pleasure' and 'health'. Study 2 surveyed a UK-representative adult sample (1042 females, 968 males) to perform exploratory (n = 1005) and confirmatory (n = 1005) factor analyses. Internal consistency, measurement invariance, and associations between latent motives and body mass index (BMI), self-reported weight change, lifetime weight loss attempts, eating rate and physical activity were examined. Exploratory and confirmatory factor analyses revealed a seven-factor, 28-item model (reactive eating, restricted eating, negative emotional eating, positive emotional eating, homeostatic eating, eating for pleasure and eating for health) with good model fit (CFI = 0.993, SRMR = 0.045, RMSEA = 0.046) and good to excellent reliability (omegaT = 0.77-0.93). Scalar invariance by sex, age, and education was supported. Latent motives showed theoretically consistent associations with external outcomes: higher reactive and negative emotional eating related to higher BMI and faster eating rate; homeostatic and health motives related to lower BMI and higher physical activity. The 7-Factor Motivation for Eating Profile (MEP-7) provides a brief, psychometrically robust profile of seven eating behaviour motivations with evidence of predictive validity. The MEP-7 supports research and clinical phenotyping and may inform behaviour change strategies for weight management. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Dakin, Clarissa AU - Dakin C AD - School of Food Science and Nutrition, University of Leeds, Leeds, LS2 9JT, UK. Electronic address: psccda@leeds.ac. FAU - Finlayson, Graham AU - Finlayson G AD - Appetite Control and Energy Balance Research Group (ACEB), School of Psychology, Faculty of Medicine and Health, University of Leeds, Leeds, UK. FAU - James Stubbs, R AU - James Stubbs R AD - Appetite Control and Energy Balance Research Group (ACEB), School of Psychology, Faculty of Medicine and Health, University of Leeds, Leeds, UK. LA - eng PT - Journal Article PT - Validation Study DEP - 20260625 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - *Motivation MH - Male MH - *Feeding Behavior/psychology MH - Adult MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Psychometrics MH - Body Mass Index MH - Emotional Eating MH - Factor Analysis, Statistical MH - Middle Aged MH - Young Adult MH - United Kingdom MH - *Eating/psychology MH - Obesity/psychology MH - Exercise/psychology MH - Adolescent MH - Pleasure OTO - NOTNLM OT - Eating behaviour traits OT - Factor analysis OT - Item response theory OT - Motivations for eating OT - Psychometrics OT - Weight management COIS- Declaration of competing interest Pr. James Stubbs and Dr Clarissa Dakin declare that they consult for Slimming World UK through the University of Leeds. Slimming World were not involved in the analysis or interpretation of this articles. No other authors declare a conflict of interest. EDAT- 2026/06/26 00:47 MHDA- 2026/08/08 00:40 CRDT- 2026/06/25 19:32 PHST- 2026/03/06 00:00 [received] PHST- 2026/06/10 00:00 [revised] PHST- 2026/06/25 00:00 [accepted] PHST- 2026/08/08 00:40 [medline] PHST- 2026/06/26 00:47 [pubmed] PHST- 2026/06/25 19:32 [entrez] AID - S0195-6663(26)00261-8 [pii] AID - 10.1016/j.appet.2026.108699 [doi] PST - ppublish SO - Appetite. 2026 Nov 1;226:108699. doi: 10.1016/j.appet.2026.108699. Epub 2026 Jun 25. PMID- 42348754 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20261006 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Jul 13 TI - An AI-Assisted Tool to Predict Continuous Glucose Monitor Adherence in Children With Type 1 Diabetes in Oman: Protocol for a Multiphase Mixed Methods Translational Study. PG - e99626 LID - 10.2196/99626 [doi] LID - e99626 AB - BACKGROUND: Type 1 diabetes mellitus (T1DM) in children requires sustained self-management to achieve glycemic targets. Continuous glucose monitoring (CGM) has transformed pediatric diabetes care; yet, adherence to device wear remains inconsistent. In May 2024, Oman launched a national initiative distributing CGMs to children with T1DM across all governorates, creating a real-world opportunity to study adherence determinants and to develop a locally validated AI-assisted predictive tool. OBJECTIVE: This multiphase translational research project aims to (1) characterize the population of Omani children with T1DM; (2) identify demographic, psychosocial, dietary, and physical activity correlates of optimal CGM use; (3) develop, train, and validate an AI-assisted behavioral predictive tool "OMNIdiasense" to forecast CGM adherence prior to device dispensing; and (4) pilot test the OMNIdiasense tool. METHODS: Three sequential, interlinked substudies will be conducted. Substudy 1 is a retrospective cohort analysis of routinely collected Al Shifa data for all children who received CGMs between July 2024 and February 2025, with glycemic, anthropometric, and laboratory outcomes compared at baseline and at >/=3 months. Outputs on adherence prevalence, and clinical predictors become the structured input layer for the proposed AI model. Substudy 2 is a cross-sectional, mixed methods study using face-to-face structured interviews with a randomly selected sample of children aged 10-18 years, classified as "CGM optimizers" (>/=6 days/week) or "CGM subusers" (<6 days/week or discontinued); responses across validated behavioral, stress, and dietary instruments are compared. Outputs are the psychosocial and behavioral feature set, qualitative themes, and effect sizes that drive feature selection for the AI model. Substudy 3 develops the AI tool (OMNIdiasense), comprising (1) a quasi-experimental single-arm pilot among 100 existing CGM subusers and (2) a parallel pilot randomized controlled trial (n=50; 25 intervention, 25 control) among newly diagnosed children, with assessments at baseline, 3, 6, and 12 months. The primary outcome is between-group difference in CGM adherence; secondary outcomes include hemoglobin A(1c), anthropometric, cardiovascular, and laboratory measures, and barriers to use. Reporting will follow SPIRIT (Standard Protocol Items: Recommendations for Interventional Trials) 2025 (interventional component), STROBE (Strengthening the Reporting of Observational Studies in Epidemiology; observational component), the CONSORT (Consolidated Standards of Reporting Trials) 2025 extension for pilot and feasibility trials, COREQ (Consolidated Criteria for Reporting Qualitative Research; qualitative component), and TRIPOD+AI (Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis + Artificial Intelligence; predictive model). RESULTS: The proposed AI tool is intended as a decision-support adjunct and not a gatekeeping mechanism for CGM access. CONCLUSIONS: To our knowledge, OMNIdiasense is the first AI tool in the Gulf Cooperation Council region to predict pediatric CGM adherence. By targeting behaviorally vulnerable patients before sensor distribution, OMNIdiasense is expected to support clinical benefit and reduce financial waste. TRIAL REGISTRATION: ISRCTN Registry ISRCTN15827616; https://doi.org/10.1186/ISRCTN15827616. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/99626. CI - (c)Thamra Al Ghafri, Saud Al Harthi, Asma Bait Ishaq, Huwaida Al Harthi, Maryam Al Muaini, Rahma Al-Ghadani, Ahmed Aljufaili, Mohamed Al Harb, Abdullah Al Saadi, Abdelhamid Abdessalem, Noushath Shaffi, Mohamed Ahmed, Said Jaboob, Nadia Al Maqbali, Moza Al-Shehhi, Talib Al Kalbani, Amal Al Shukaili, Jannat Al Harthi. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 13.07.2026. FAU - Al Ghafri, Thamra AU - Al Ghafri T AUID- ORCID: 0000-0002-4818-9565 AD - Directorate General of Health Services, Muscat, Oman. AD - Sultan Qaboos University, Muscat, Muscat, Oman. FAU - Al Harthi, Saud AU - Al Harthi S AUID- ORCID: 0000-0002-5457-4662 AD - Ministry of Health, Directorate General of Khaula Hospital, Muscat, Oman. FAU - Bait Ishaq, Asma AU - Bait Ishaq A AUID- ORCID: 0009-0009-7263-2692 AD - Directorate General of Health Services, Muscat, Oman. FAU - Al Harthi, Huwaida AU - Al Harthi H AUID- ORCID: 0009-0004-1540-5796 AD - Directorate General of Health Services, Muscat, Oman. FAU - Al Muaini, Maryam AU - Al Muaini M AUID- ORCID: 0009-0002-4555-427X AD - Ministry of Health, Ministry of Health, Batina, Oman. FAU - Al-Ghadani, Rahma AU - Al-Ghadani R AUID- ORCID: 0009-0008-1130-7987 AD - Ministry of Health, Ministry of Health, Batina, Oman. FAU - Aljufaili, Ahmed AU - Aljufaili A AUID- ORCID: 0009-0004-0480-3422 AD - Ministry of Health, Ministry of Health, Sharqiyah, Oman. FAU - Al Harb, Mohamed AU - Al Harb M AUID- ORCID: 0009-0007-7035-2350 AD - Ministry of Health, Ministry of Health, Sharqiyah, Oman. FAU - Al Saadi, Abdullah AU - Al Saadi A AUID- ORCID: 0009-0007-8798-0353 AD - Ministry of Health, Ministry of Health, Sharqiyah, Oman. FAU - Abdessalem, Abdelhamid AU - Abdessalem A AUID- ORCID: 0000-0003-2950-2875 AD - Sultan Qaboos University, Muscat, Muscat, Oman. FAU - Shaffi, Noushath AU - Shaffi N AUID- ORCID: 0000-0001-9243-8402 AD - Sultan Qaboos University, Muscat, Muscat, Oman. FAU - Ahmed, Mohamed AU - Ahmed M AUID- ORCID: 0009-0000-9458-9087 AD - Ministry of Health, Ministry of Health, AlWosta, Oman. FAU - Jaboob, Said AU - Jaboob S AUID- ORCID: 0009-0009-6411-7244 AD - Ministry of Health, Ministry of Health, Dhofar, Oman. FAU - Al Maqbali, Nadia AU - Al Maqbali N AUID- ORCID: 0000-0002-9926-6452 AD - Ministry of Health, Ministry of Health, Aldhahira, Oman. FAU - Al-Shehhi, Moza AU - Al-Shehhi M AUID- ORCID: 0000-0002-1001-2043 AD - Ministry of Health, Ministry of Health, Musandam, Oman. FAU - Al Kalbani, Talib AU - Al Kalbani T AUID- ORCID: 0000-0003-4585-0992 AD - Ministry of Health, Ministry of Health, Buraimi, Oman. FAU - Al Shukaili, Amal AU - Al Shukaili A AUID- ORCID: 0009-0002-6884-6689 AD - Ministry of Health, Ministry of Health, Aldakhilyah, Oman. FAU - Al Harthi, Jannat AU - Al Harthi J AUID- ORCID: 0009-0007-4182-5462 AD - National University of Science and Technology, Sohar, Oman. LA - eng SI - ISRCTN/ISRCTN15827616 PT - Clinical Trial Protocol PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260713 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 RN - 0 (Blood Glucose) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Artificial Intelligence MH - Blood Glucose/analysis MH - *Blood Glucose Self-Monitoring MH - *Continuous Glucose Monitoring/methods MH - *Diabetes Mellitus, Type 1/blood/psychology MH - Oman MH - *Patient Compliance/statistics & numerical data MH - Retrospective Studies MH - Observational Studies as Topic PMC - PMC13408470 OTO - NOTNLM OT - adherence OT - adolescent OT - artificial intelligence OT - behavioral prediction OT - continuous glucose monitoring OT - machine learning OT - pediatric OT - type 1 diabetes. COIS- Conflicts of Interest: None declared. EDAT- 2026/06/26 04:10 MHDA- 2026/07/14 12:34 PMCR- 2026/07/13 CRDT- 2026/06/25 14:53 PHST- 2026/04/28 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/06/21 00:00 [revised] PHST- 2026/07/14 12:34 [medline] PHST- 2026/06/26 04:10 [pubmed] PHST- 2026/06/25 14:53 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - v15i1e99626 [pii] AID - 10.2196/99626 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Jul 13;15:e99626. doi: 10.2196/99626. PMID- 42348623 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260629 IS - 2327-2228 (Electronic) VI - 109 IP - 7 DP - 2026 Jul 1 TI - An Open Pilot Trial of a Physical Activity (PA) Intervention Designed to Address Barriers Experienced by Hispanic and Black Mothers. PG - 18-26 AB - INTRODUCTION: Mothers, especially those with marginalized identities, often struggle to meet physical activity (PA) guidelines. We examined feasibility, acceptability, and preliminary efficacy of Moms on the Move (MOMs), a community-based PA promotion intervention targeting Hispanic and Black mothers delivered in partnership with a youth sports organization in Providence, RI. METHODS: Feasibility targets centered around enrollment (i.e., n>30 participants), retention (i.e., >80% of participants through follow-up), and assessment (i.e., collection of PA data from >80% of participants at multiple timepoints), while acceptability targets centered around participant satisfaction (i.e., >80% of participants being satisfied with the intervention). For preliminary efficacy, we assessed weekly minutes of moderate-to- vigorous intensity PA (MVPA) via 7-Day PA Recall (PAR) at baseline, intervention end (8 weeks), and follow-up (12 weeks), and examined within-person changes in MVPA over time using paired T-tests. Stratified analysis was used to examine differences between participants who were already meeting the national guideline of >150 minutes of MVPA per week at baseline and those who were not. RESULTS: We met recruitment (n=35) and retention (94%) targets but only collected PA data at multiple timepoints from 21 participants (64%). Most participants (94%) were satisfied with the intervention, all (100%) said they learned from the program, and all (100%) said they would recommend participation to a friend. Participants who were not meeting the MVPA guideline at baseline (n=12) reported an increase in MVPA at both intervention end (mean change: 110.27 minutes, Cohen's d: 0.89) and follow-up (mean change: 82.09 minutes, Cohen's d: 0.76). CONCLUSIONS: Findings around recruitment, retention, and participant satisfaction were promising, though assessing MVPA via the PAR, which requires a semi-structured interview, proved challenging. Nonetheless, the findings, which also showed that insufficiently active mothers had significantly higher levels of MVPA at intervention end and follow-up, support testing MOMs in a fully powered, randomized controlled trial. FAU - von Ash, Tayla AU - von Ash T AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI. FAU - Gupta-Louis, Sugandha K AU - Gupta-Louis SK AD - Department of Psychology, Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY. FAU - O'Hagan, Belinda AU - O'Hagan B AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI. FAU - Onu, Michael AU - Onu M AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI. FAU - Dunsiger, Shira AU - Dunsiger S AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI. FAU - Maxwell, Zoe AU - Maxwell Z AD - Weight Control and Diabetes Research Center, Brown University, Providence, RI. FAU - Alacron, Ashlie AU - Alacron A AD - Weight Control and Diabetes Research Center, Brown University, Providence, RI. FAU - Brown, Candace S AU - Brown CS AD - Department of Epidemiology and Com- munity Health, University of North Carolina, Charlotte, NC. FAU - Marcus, Bess H AU - Marcus BH AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI. LA - eng PT - Journal Article DEP - 20260701 PL - United States TA - R I Med J (2013) JT - Rhode Island medical journal (2013) JID - 101605827 SB - IM MH - Humans MH - Pilot Projects MH - *Hispanic or Latino MH - Female MH - *Exercise MH - *Black or African American MH - *Mothers/psychology MH - *Health Promotion/methods MH - Adult MH - Feasibility Studies OTO - NOTNLM OT - community-based OT - mothers OT - physical activity OT - pilot OT - youth sports EDAT- 2026/06/26 00:53 MHDA- 2026/06/26 00:54 CRDT- 2026/06/25 13:44 PHST- 2026/06/26 00:54 [medline] PHST- 2026/06/26 00:53 [pubmed] PHST- 2026/06/25 13:44 [entrez] PST - epublish SO - R I Med J (2013). 2026 Jul 1;109(7):18-26. PMID- 42348608 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260811 IS - 1473-6519 (Electronic) IS - 1363-1950 (Linking) VI - 29 IP - 5 DP - 2026 Sep 1 TI - Pediatric and adolescent nutritional and metabolic assessment in the precision era. PG - 441-447 LID - 10.1097/MCO.0000000000001244 [doi] AB - PURPOSE OF REVIEW: To summarize recent methodological and technological advances in assessing nutritional and metabolic status among pediatric and adolescent populations, with emphasis on their translational value within precision and personalized nutrition. This review highlights how integrative, multi-omics, and digital approaches may complement the evaluation of body composition, dietary intake, metabolic profiling, and behavioral monitoring in youth. RECENT FINDINGS: Recent findings suggest that combining compositional imaging (DXA, 3D optical, ultrasound) with bioelectrical and omic biomarkers may improve multidimensional nutritional profiling. Digital dietary assessment, biosensors, and continuous glucose monitoring may enhance real-time dietary and metabolic characterization in selected research or clinical contexts. Moreover, machine-learning models and multi-omic integration show promise individualized risk prediction and adaptive feedback, although their clinical utility requires further validation. However, standardization of protocols and pediatric reference datasets remains a key challenge. SUMMARY: Nutritional and metabolic assessment in children and adolescents is progressively moving toward integrative frameworks that combine imaging, omics, and digital monitoring. These approaches may support more individualized and developmentally sensitive evaluations, but harmonization of protocols, ethical governance, accessibility, and pediatric reference datasets remain essential before broad clinical implementation. CI - Copyright (c) 2026 Wolters Kluwer Health, LLC. All rights reserved. FAU - Jurado-Castro, Jose Manuel AU - Jurado-Castro JM AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba. AD - CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid. AD - Ciencias de la Actividad Fisica y El Deporte, Escuela Universitaria de Osuna (Centro Adscrito a la Universidad de Sevilla), Osuna. FAU - Pastor-Villaescusa, Belen AU - Pastor-Villaescusa B AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba. AD - Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS), RD21/0012/0008, Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS-SAMID, RD24/0013/0007), Instituto de Salud Carlos III, Madrid. FAU - Llorente-Cantarero, Francisco Jesus AU - Llorente-Cantarero FJ AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba. AD - CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid. AD - Department of Specific Didactics, Faculty of Education, University of Cordoba, Cordoba, Spain. FAU - Gil-Campos, Mercedes AU - Gil-Campos M AD - Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba. AD - CIBER Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid. LA - eng PT - Journal Article PT - Review DEP - 20260603 PL - England TA - Curr Opin Clin Nutr Metab Care JT - Current opinion in clinical nutrition and metabolic care JID - 9804399 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Child MH - Adolescent MH - *Nutrition Assessment MH - *Precision Medicine/methods MH - *Nutritional Status MH - Multiomics MH - Digital Health MH - Machine Learning MH - Biomarkers MH - Body Composition OTO - NOTNLM OT - dietary assessment OT - machine learning OT - multi-omics integration OT - pediatric nutrition OT - personalized intervention EDAT- 2026/06/26 00:43 MHDA- 2026/08/06 12:37 CRDT- 2026/06/25 13:44 PHST- 2026/08/06 12:37 [medline] PHST- 2026/06/26 00:43 [pubmed] PHST- 2026/06/25 13:44 [entrez] AID - 00075197-202609000-00004 [pii] AID - 10.1097/MCO.0000000000001244 [doi] PST - ppublish SO - Curr Opin Clin Nutr Metab Care. 2026 Sep 1;29(5):441-447. doi: 10.1097/MCO.0000000000001244. Epub 2026 Jun 3. PMID- 42347433 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260625 LR - 20260813 IS - 2305-6304 (Electronic) IS - 2305-6304 (Linking) VI - 14 IP - 6 DP - 2026 Jun 20 TI - Storage-Dependent Changes in Microplastic-Associated Recoverable Residues in Yogurt Containing Bifidobacterium longum subsp. infantis. LID - 10.3390/toxics14060535 [doi] LID - 535 AB - Microplastics (MPs) are increasingly detected in dairy products, raising food-safety concerns. Their behavior in complex food matrices and interactions with probiotic microorganisms remain poorly understood. This exploratory study evaluated storage-dependent changes in operationally defined, digestion-resistant recoverable residues in yogurt containing Bifidobacterium longum subsp. infantis (ATCC 15697). Yogurt samples were prepared with polypropylene (PP), polyethylene (PE), and polystyrene (PS), individually and in combination, and analyzed over 21 days of refrigerated storage. Gravimetric values served as relative, operational indicators of recoverable residues-not validated absolute polymer masses-while polymer identity was qualitatively confirmed by pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS). B. longum subsp. infantis remained viable throughout storage (6.3-8.2 log(10) CFU/g). All MP-containing groups showed consistent storage-associated decreases in recoverable residue fractions, greatest in PP, followed by PE and PS; probiotic-free controls remained stable. Polymer-specific Py-GC/MS signals were detectable at all time points. Because polymer identity was retained and the workflow was not validated for absolute recovery, findings are interpreted as storage-associated changes in extractability, filterability, and/or residue recovery-not as polymer degradation, mineralization, or biological removal. These in vitro observations are limited to the yogurt matrix and do not support extrapolation to livestock exposure, human dietary risk, or farm-to-fork transfer. Within these limits, the findings provide a preliminary, hypothesis-generating perspective on probiotic-microplastic interactions in fermented dairy products. FAU - Akkemik, Yasin AU - Akkemik Y AUID- ORCID: 0000-0002-9086-0324 AD - Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Kastamonu University, Kastamonu 37100, Turkiye. FAU - Ozcan, Sedat AU - Ozcan S AUID- ORCID: 0000-0001-9235-4049 AD - Department of Veterinary, Menemen Vocational School, Izmir Bakircay University, Izmir 35660, Turkiye. FAU - Dogan, Veysel AU - Dogan V AD - Department of Animal Nutrition and Nutritional Diseases, Faculty of Veterinary Medicine, Kastamonu University, Kastamonu 37100, Turkiye. FAU - Gokmen, Sedat AU - Gokmen S AD - Department of Veterinary Pharmacology, Faculty of Veterinary Medicine, Kastamonu University, Kastamonu 37100, Turkiye. FAU - Tufekci, Enis Fuat AU - Tufekci EF AUID- ORCID: 0000-0001-5051-2694 AD - Department of Basic Medical Sciences, Faculty of Medicine, Kastamonu University, Kastamonu 37100, Turkiye. FAU - Erat, Salih AU - Erat S AUID- ORCID: 0000-0003-4413-6041 AD - Department of Veterinary, Menemen Vocational School, Izmir Bakircay University, Izmir 35660, Turkiye. LA - eng GR - BBAP.2024.007/Izmir Bakircay University/ PT - Journal Article DEP - 20260620 PL - Switzerland TA - Toxics JT - Toxics JID - 101639637 PMC - PMC13307711 OTO - NOTNLM OT - Bifidobacterium longum subsp. infantis OT - Py-GC/MS OT - dairy food safety OT - exploratory study OT - microplastics OT - probiotic-microplastic interactions OT - recoverable residue OT - yogurt COIS- The authors declare no conflicts of interest. EDAT- 2026/06/25 12:38 MHDA- 2026/06/25 12:39 PMCR- 2026/06/20 CRDT- 2026/06/25 09:55 PHST- 2026/05/04 00:00 [received] PHST- 2026/06/12 00:00 [revised] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/06/25 12:39 [medline] PHST- 2026/06/25 12:38 [pubmed] PHST- 2026/06/25 09:55 [entrez] PHST- 2026/06/20 00:00 [pmc-release] AID - toxics14060535 [pii] AID - toxics-14-00535 [pii] AID - 10.3390/toxics14060535 [doi] PST - epublish SO - Toxics. 2026 Jun 20;14(6):535. doi: 10.3390/toxics14060535. PMID- 42347082 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260625 LR - 20260813 IS - 2571-841X (Electronic) IS - 2571-841X (Linking) VI - 9 IP - 2 DP - 2026 May 28 TI - Predictive Analysis of Extubation Failure in the Paediatric Intensive Care Unit in Bloemfontein, South Africa. LID - 10.3390/reports9020169 [doi] LID - 169 AB - Background: Extubation failure (EF) is a significant complication, and it is associated with increased mortality, prolonged hospital stays and extended mechanical ventilation (MV). Determining reliable predictors of EF could improve the clinical decision-making and outcomes. Objectives: Determine the outcomes and predictors of EF in a paediatric intensive care unit (PICU) and develop predictive models using machine learning algorithms. Methods: A retrospective cohort study (n = 824) was conducted in two PICUs in participants who underwent planned extubation (January 2018-December 2022). Demographic characteristics, clinical parameters, ventilator setting, laboratory findings and extubation outcomes were collected. Univariate and multivariate analysis were performed to identify significant predictors of EF. Six machine learning algorithms-Logistic Regression (LR), Artificial Neural Network (ANN), Extreme Gradient Boosting (XGBoost), Random Forest (RF), Support Vector Machine (SVM) and Decision Tree (DT)-were developed and validated for prediction of EF. Results: The overall EF rate was 231 (28%). Multivariate analysis identified a mechanical ventilation for a duration of 3 days or more (aOR 4.49, 95% CI 3.24-6.57, p < 0.001), use of neuromuscular blockade (aOR 1.32, 95% CI 1.07-1.63, p = 0.009), and administration of vasopressors (aOR 1.57, 95% CI 1.24-2.01, p < 0.001) as significant independent predictors of EF. The ANN and LR models demonstrated the highest performance with AUCROC of 0.87 +/- 0.04 and 0.86 +/- 0.02, respectively. Conclusions: Extubation failure was common in our setting (28%) compared to other studies. Days of ventilation, undernutrition, use of neuromuscular blockade, use of vasopressors or inotropes and CNS comorbidity were associated with EF. The main cause of EF was upper airway obstruction. FAU - Buankuna, Mbaya AU - Buankuna M AD - Department of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein 9301, Free State, South Africa. FAU - Sempa, Joseph B AU - Sempa JB AD - Department of Biostatistics, School of Clinical Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein 9301, Free State, South Africa. FAU - Khaliq, Olive P AU - Khaliq OP AD - Department of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein 9301, Free State, South Africa. FAU - Pienaar, Michael A AU - Pienaar MA AUID- ORCID: 0000-0001-6427-0278 AD - Department of Paediatrics and Child Health, School of Clinical Medicine, Faculty of Health Sciences, University of the Free State, Bloemfontein 9301, Free State, South Africa. LA - eng PT - Journal Article DEP - 20260528 PL - Switzerland TA - Reports (MDPI) JT - Reports (MDPI) JID - 101757880 PMC - PMC13306389 OTO - NOTNLM OT - extubation failure OT - intensive care OT - mechanical ventilation OT - paediatrics COIS- The authors declare no conflicts of interest. EDAT- 2026/06/25 12:38 MHDA- 2026/06/25 12:39 PMCR- 2026/05/28 CRDT- 2026/06/25 09:53 PHST- 2026/02/13 00:00 [received] PHST- 2026/03/31 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/06/25 12:39 [medline] PHST- 2026/06/25 12:38 [pubmed] PHST- 2026/06/25 09:53 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - reports9020169 [pii] AID - reports-09-00169 [pii] AID - 10.3390/reports9020169 [doi] PST - epublish SO - Reports (MDPI). 2026 May 28;9(2):169. doi: 10.3390/reports9020169. PMID- 42346830 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260813 IS - 2076-3271 (Electronic) IS - 2076-3271 (Linking) VI - 14 IP - 2 DP - 2026 Jun 5 TI - Virtual Reality-Supported Speech Therapy in Children with Developmental Language Disorder: A Randomized Controlled Trial. LID - 10.3390/medsci14020291 [doi] LID - 291 AB - BACKGROUND/OBJECTIVES: Digital technologies are increasingly explored as complementary tools in speech and language therapy for children with neurodevelopmental disorders. However, evidence on virtual reality-based interventions for children with developmental language disorder (DLD) remains limited. This study aimed to evaluate the effects of a Virtual Reality Rehabilitation System (VRRS)-based language intervention combined with standard speech therapy in preschool children with DLD. Secondary objectives included assessing the feasibility, usability, and safety of the VRRS-integrated intervention. METHODS: A randomized controlled pilot study was conducted in preschool children diagnosed with DLD. Participants were allocated to an experimental group receiving VRRS-based language intervention integrated with conventional therapy or to a control group receiving standard speech therapy alone. Both groups attended two 60 min sessions per week for six months. Clinical language outcomes were assessed at baseline (T0) and post-intervention (T1). Feasibility was evaluated through adherence and retention rates, usability through a therapist-completed questionnaire, and safety through monitoring of adverse events during sessions. RESULTS: All participants in the experimental group completed the intervention (100% retention). No adverse events were observed. Therapists reported good usability of the VRRS system, highlighting ease of exercise customization, intuitive monitoring of progress, and good integration into routine therapy. CONCLUSIONS: VRRS-based activities integrated into conventional speech therapy appear feasible, safe, and well accepted in preschool children with DLD. Further controlled studies with larger samples are needed to confirm these findings. TRIAL REGISTRATION: ClinicalTrials.gov (NCT07438639). FAU - De Domenico, Carmela AU - De Domenico C AUID- ORCID: 0009-0007-8868-8485 AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - La Fauci, Margherita AU - La Fauci M AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Mancuso, Noemi AU - Mancuso N AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Caputo, Mariarita AU - Caputo M AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Di Cara, Marcella AU - Di Cara M AUID- ORCID: 0000-0002-4275-4340 AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Piccolo, Adriana AU - Piccolo A AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Fulgenzi, Alessia AU - Fulgenzi A AUID- ORCID: 0009-0000-4028-1407 AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Borzelli, Daniele AU - Borzelli D AUID- ORCID: 0000-0002-9456-0177 AD - Laboratory of Physiology, Department of Translational Medicine, Universita del Piemonte Orientale, 28100 Novara, Italy. AD - Laboratory of Neuromotor Physiology, IRCCS Santa Lucia Foundation, 00179 Rome, Italy. FAU - Impallomeni, Caterina AU - Impallomeni C AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Tripodi, Emanuela AU - Tripodi E AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Calabro, Rocco Salvatore AU - Calabro RS AUID- ORCID: 0000-0002-8566-3166 AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Quartarone, Angelo AU - Quartarone A AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. FAU - Cucinotta, Francesca AU - Cucinotta F AUID- ORCID: 0000-0001-8477-7826 AD - IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. LA - eng SI - ClinicalTrials.gov/NCT07438639 GR - Ministero della Salute/ PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20260605 PL - Switzerland TA - Med Sci (Basel) JT - Medical sciences (Basel, Switzerland) JID - 101629322 SB - IM MH - Humans MH - *Language Development Disorders/therapy/rehabilitation MH - Child, Preschool MH - Male MH - Female MH - *Virtual Reality MH - *Speech Therapy/methods MH - Pilot Projects MH - Language Therapy/methods MH - Treatment Outcome PMC - PMC13304140 OTO - NOTNLM OT - developmental language disorder OT - neurodevelopmental disorders OT - speech therapy intervention OT - virtual reality rehabilitation system COIS- The authors declare no conflicts of interest. EDAT- 2026/06/25 16:09 MHDA- 2026/06/25 16:10 PMCR- 2026/06/05 CRDT- 2026/06/25 09:45 PHST- 2026/03/24 00:00 [received] PHST- 2026/05/14 00:00 [revised] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/06/25 16:10 [medline] PHST- 2026/06/25 16:09 [pubmed] PHST- 2026/06/25 09:45 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - medsci14020291 [pii] AID - medsci-14-00291 [pii] AID - 10.3390/medsci14020291 [doi] PST - epublish SO - Med Sci (Basel). 2026 Jun 5;14(2):291. doi: 10.3390/medsci14020291. PMID- 42346395 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260625 LR - 20260813 IS - 2218-1989 (Print) IS - 2218-1989 (Electronic) IS - 2218-1989 (Linking) VI - 16 IP - 6 DP - 2026 Jun 14 TI - Discriminative Ability of TyG, TyG-WC, BAI, FGIR, and QUICKI Indexes in Identifying Metabolic Syndrome in a Pediatric Population with Obesity. LID - 10.3390/metabo16060415 [doi] LID - 415 AB - Background/Objectives: Pediatric obesity is closely associated with metabolic syndrome (MetS), a condition linked to increased cardiometabolic risk. Early identification of high-risk individuals remains challenging. This study aimed to evaluate the diagnostic performance of selected anthropometric, metabolic dysfunction and insulin resistance indexes for identifying MetS in children and adolescents with obesity. Methods: In this retrospective, cross-sectional, single-center study, 758 children and adolescents with obesity (mean age 14.8 +/- 2.1 years; 59.9% females) hospitalized for a body weight-reduction program were included. MetS was defined according to International Diabetes Federation criteria, in which central obesity is a mandatory diagnostic component. The triglyceride-glucose (TyG), TyG-waist circumference (TyG-WC), body adiposity index (BAI), fasting glucose-to-insulin ratio (FGIR), and quantitative insulin sensitivity check index (QUICKI) were calculated. Receiver operating characteristic curve analysis was used to assess their discriminative ability. Results: The prevalence of MetS was 27.8% and was significantly higher in males than females (34.9% vs. 23.1%, p < 0.0001). TyG and TyG-WC showed the best discriminative performance (AUC 0.75 and 0.76, respectively), although with only moderate sensitivity and specificity. FGIR and QUICKI demonstrated lower accuracy (AUC 0.64 and 0.63), whereas BAI showed no discriminative ability (AUC 0.48). These findings were consistent across sexes, although sex-specific differences in both MetS prevalence and optimal cut-off values were observed. Correlation analyses confirmed moderate associations between TyG-based indexes and MetS, whereas other indexes showed weaker relationships. Conclusions: In the present cohort of children and adolescents with obesity, TyG and TyG-WC showed the best performance in identifying MetS compared with the other evaluated indexes. However, their performance remained moderate, and the proposed cut-off values require validation in independent populations. These indexes may represent simple supportive screening and risk-stratification tools but should be used alongside comprehensive clinical assessment and established diagnostic criteria rather than as stand-alone diagnostic measures. FAU - Tamini, Sofia AU - Tamini S AUID- ORCID: 0000-0002-2503-5117 AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo, 28824 Verbania, Italy. FAU - Bondesan, Adele AU - Bondesan A AUID- ORCID: 0000-0002-9145-5400 AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo, 28824 Verbania, Italy. FAU - Caroli, Diana AU - Caroli D AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo, 28824 Verbania, Italy. FAU - Frigerio, Francesca AU - Frigerio F AUID- ORCID: 0009-0007-1227-1747 AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo, 28824 Verbania, Italy. FAU - Sartorio, Alessandro AU - Sartorio A AUID- ORCID: 0000-0002-9620-4133 AD - Experimental Laboratory for Auxo-Endocrinological Research, Istituto Auxologico Italiano, IRCCS, Piancavallo, 28824 Verbania, Italy. LA - eng GR - ricerca corrente/Ministry of Health/ PT - Journal Article DEP - 20260614 PL - Switzerland TA - Metabolites JT - Metabolites JID - 101578790 PMC - PMC13303531 OTO - NOTNLM OT - FGIR OT - MetS OT - QUICKI OT - TyG OT - TyG-WC OT - adolescents OT - children OT - metabolic syndrome OT - obesity OT - pediatric obesity COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/25 19:09 MHDA- 2026/06/25 19:10 PMCR- 2026/06/14 CRDT- 2026/06/25 09:43 PHST- 2026/05/06 00:00 [received] PHST- 2026/06/10 00:00 [revised] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/06/25 19:10 [medline] PHST- 2026/06/25 19:09 [pubmed] PHST- 2026/06/25 09:43 [entrez] PHST- 2026/06/14 00:00 [pmc-release] AID - metabo16060415 [pii] AID - metabolites-16-00415 [pii] AID - 10.3390/metabo16060415 [doi] PST - epublish SO - Metabolites. 2026 Jun 14;16(6):415. doi: 10.3390/metabo16060415. PMID- 42345641 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260813 IS - 2543-6031 (Electronic) IS - 2451-4934 (Print) IS - 2451-4934 (Linking) VI - 94 IP - 3 DP - 2026 Jun 5 TI - Impact of Highly Effective CFTR Modulator Therapy on Physical Activity, Sleep, and Sinonasal Symptoms in Preschool Children with Cystic Fibrosis: A Prospective Single-Center Pilot Study. LID - 10.3390/arm94030036 [doi] LID - 36 AB - Background: Highly effective CFTR modulation with Elexacaftor/Tezacaftor/Ivacaftor (ETI) markedly improves clinical outcomes in people with cystic fibrosis (CF). Data on its effects on physical activity, sleep, sinonasal symptoms, and parent-perceived outcomes in preschool-aged children are limited. Methods: In this prospective, observational, single-center cohort study, ten children with cystic fibrosis (aged 2-6 years) and at least one CFTR variant eligible for ETI were included. Data were collected using wrist-worn Garmin vivofit Junior 2 activity trackers and standardized questionnaires one month before ETI initiation and at 1, 3, 6, and 12 months after start of ETI. Outcomes included step count, minutes of moderate-to-vigorous physical activity, sleep parameters, sinonasal symptoms, and parental perceptions. Results: ETI was well tolerated. Sweat chloride levels decreased significantly. Physical activity improved at 3 and 6 months (step count and active minutes/day; p < 0.05) but declined to near-baseline levels at 12 months. Parental assessments of physical and sporting performance showed sustained improvement. Sleep duration remained stable, with no changes in deep or light sleep phases or nighttime awakenings. Sinonasal symptoms remained low. Discussion & Conclusions: Preliminary findings of this exploratory pilot study show that improvement in physical activity after three and six months of ETI therapy might be attributable to seasonality, as therapy was started in winter months. No changes in sleep duration or sleep patterns are reassuring in this small cohort of young children with CF. ETI therapy was safe and well tolerated. Parental appraisal of their children's physical performance improved after start of ETI. Longitudinal, controlled studies involving larger cohorts are required to validate these findings and to account for potential confounding factors, such as age-dependent changes and individual and environmental factors such as seasonal variation. FAU - Schellhorn, Stella AU - Schellhorn S AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. FAU - Schmidt, Hanna AU - Schmidt H AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. FAU - Janda, Ales AU - Janda A AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. FAU - Gulke, Doris AU - Gulke D AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. FAU - Toth, Monika AU - Toth M AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. FAU - Fabricius, Dorit AU - Fabricius D AUID- ORCID: 0000-0002-2019-8101 AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. FAU - Bode, Sebastian F N AU - Bode SFN AUID- ORCID: 0000-0001-7217-3312 AD - Department of Pediatrics and Adolescent Medicin, Ulm University Medical Center, Ulm University, Eythstrasse 24, 89075 Ulm, Germany. LA - eng PT - Journal Article PT - Observational Study DEP - 20260605 PL - Switzerland TA - Adv Respir Med JT - Advances in respiratory medicine JID - 101697329 RN - 0 (Aminophenols) RN - 0 (Quinolones) RN - 126880-72-6 (Cystic Fibrosis Transmembrane Conductance Regulator) RN - 0 (Pyrazoles) RN - 0 (Benzodioxoles) RN - 0 (Indoles) RN - 0 (Pyridines) RN - RRN67GMB0V (elexacaftor) RN - 8RW88Y506K (tezacaftor) RN - 0 (Drug Combinations) RN - 1Y740ILL1Z (ivacaftor) RN - 0 (Thiophenes) RN - 0 (Pyrrolidines) SB - IM MH - Humans MH - Pilot Projects MH - Prospective Studies MH - Child, Preschool MH - Female MH - Male MH - *Cystic Fibrosis/drug therapy/complications/physiopathology MH - Child MH - *Exercise MH - *Aminophenols/therapeutic use MH - *Quinolones/therapeutic use MH - *Cystic Fibrosis Transmembrane Conductance Regulator/genetics MH - *Pyrazoles/therapeutic use MH - *Benzodioxoles/therapeutic use MH - *Indoles/therapeutic use MH - *Pyridines/therapeutic use MH - *Sleep/drug effects MH - Drug Combinations MH - Thiophenes/therapeutic use MH - Pyrrolidines PMC - PMC13296162 OTO - NOTNLM OT - CFTR-modulator OT - actigraphy OT - activity OT - cystic fibrosis OT - preschool children OT - sinonasal symptoms OT - sleep OT - wearables COIS- The authors declare no conflict of interest. EDAT- 2026/06/25 12:38 MHDA- 2026/06/25 12:39 PMCR- 2026/06/05 CRDT- 2026/06/25 09:33 PHST- 2026/04/28 00:00 [received] PHST- 2026/06/01 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/25 12:39 [medline] PHST- 2026/06/25 12:38 [pubmed] PHST- 2026/06/25 09:33 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - arm94030036 [pii] AID - arm-94-00036 [pii] AID - 10.3390/arm94030036 [doi] PST - epublish SO - Adv Respir Med. 2026 Jun 5;94(3):36. doi: 10.3390/arm94030036. PMID- 42344529 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260625 LR - 20260813 IS - 1178-2390 (Print) IS - 1178-2390 (Electronic) IS - 1178-2390 (Linking) VI - 19 DP - 2026 TI - Family Empowerment for Stunting Prevention in Children Aged 0-2 Years: A Concept Analysis. PG - 616138 LID - 10.2147/JMDH.S616138 [doi] LID - 616138 AB - BACKGROUND: Stunting in children aged 0-2 years remains a major global health challenge, particularly in low‑ and middle‑income countries, with long‑term consequences for growth and development. Although family empowerment is widely promoted as a strategy for stunting prevention, its conceptualization within stimulation, early detection, and family‑centered care remains fragmented. METHODS: Guided by Walker and Avant's concept analysis framework, this study systematically examined literature retrieved from PubMed, Scopus, and Google Scholar (July 2025). Studies were screened for relevance to family empowerment, caregiving, health literacy, and growth monitoring in the context of children aged 0-2 years. RESULTS: Twenty‑seven eligible studies were synthesized to refine the construct of family empowerment in stunting prevention. Across the reviewed literature, family empowerment was consistently conceptualized as a multidimensional process characterized by five interrelated attributes-reflective decision‑making, self‑efficacy, participation, health literacy integration, and resource mobilization-positioning families as active agents in growth monitoring, stimulation, and timely intervention during the first 1000 days of life. CONCLUSION: This analysis reframes family empowerment as a strategic, family‑centered pathway for stunting prevention. By advancing conceptual clarity within nursing and culturally diverse caregiving contexts, the findings inform practice and policy through the integration of empowerment indicators alongside growth monitoring and highlight priorities for future research focused on culturally responsive validation of empowerment measures. CI - (c) 2026 Sutini et al. FAU - Sutini, Titin AU - Sutini T AUID- ORCID: 0000-0003-1077-0992 AD - Faculty of Nursing, Universitas Padjadjaran, Bandung, Indonesia. AD - Faculty of Nursing, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia. FAU - Rakhmawati, Windy AU - Rakhmawati W AUID- ORCID: 0000-0001-7173-4886 AD - Faculty of Nursing, Universitas Padjadjaran, Bandung, Indonesia. FAU - Mediani, Henny Suzana AU - Mediani HS AUID- ORCID: 0000-0001-6960-3692 AD - Faculty of Nursing, Universitas Padjadjaran, Bandung, Indonesia. FAU - Permatasari, Tria Astika Endah AU - Permatasari TAE AUID- ORCID: 0000-0001-9589-3814 AD - Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia. LA - eng PT - Journal Article PT - Review DEP - 20260618 PL - New Zealand TA - J Multidiscip Healthc JT - Journal of multidisciplinary healthcare JID - 101512691 PMC - PMC13290388 OTO - NOTNLM OT - child nutrition OT - concept analysis OT - early childhood OT - family empowerment OT - family-centre care OT - stunting prevention COIS- The authors declare no conflicts of interest in this work. EDAT- 2026/06/25 06:37 MHDA- 2026/06/25 06:38 PMCR- 2026/06/18 CRDT- 2026/06/25 04:40 PHST- 2026/04/11 00:00 [received] PHST- 2026/06/06 00:00 [accepted] PHST- 2026/06/25 06:38 [medline] PHST- 2026/06/25 06:37 [pubmed] PHST- 2026/06/25 04:40 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 616138 [pii] AID - 10.2147/JMDH.S616138 [doi] PST - epublish SO - J Multidiscip Healthc. 2026 Jun 18;19:616138. doi: 10.2147/JMDH.S616138. eCollection 2026. PMID- 42344510 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260625 LR - 20260813 IS - 1662-5161 (Print) IS - 1662-5161 (Electronic) IS - 1662-5161 (Linking) VI - 20 DP - 2026 TI - Building an auxiliary diagnostic and treatment efficacy prediction model for adolescent depression using machine learning based on electroencephalography technology. PG - 1774822 LID - 10.3389/fnhum.2026.1774822 [doi] LID - 1774822 AB - BACKGROUND: Adolescent depression, characterized by high incidence rates and significant recurrence risks, has emerged as a major global public health concern. Current diagnosis relies predominantly on subjective questionnaires, lacking objective biomarkers and presenting challenges for early identification. Although exercise intervention is recommended as a safe and effective first-line non-pharmacological treatment, individual responses vary considerably. Approximately 30-40% of patients experience limited symptom improvement, necessitating reliable neurobiological markers to predict intervention response and enable precision exercise prescription. Resting-state electroencephalography (rs-EEG), with its non-invasive nature, low cost, and high temporal resolution, represents an ideal tool for identifying objective markers of depression. This study aims to construct a high-performance auxiliary diagnostic model for adolescent depression based on static and dynamic functional connectivity features of rs-EEG, combined with machine learning algorithms. It further seeks to identify neurophysiological biomarkers capable of predicting exercise intervention efficacy, thereby providing objective and practical technical support for early identification and individualized non-pharmacological interventions. METHODOLOGY: This study employed a machine learning framework combining diagnostic and predictive models. The diagnostic model aimed to identify depressed individuals among healthy adolescents (N = 155) and those with subclinical depression (N = 149), whilst the predictive model focused on the emotional response to a virtual reality-based exercise intervention within the same depressed cohort (N = 149), categorizing participants into high, moderate, and low responders. Six-minute resting-state EEG signals were collected, preprocessed, and segmented into 78 brain regions using the Schaefer template. These regions were then grouped into five core networks (sensory-motor, dorsal attention, salience, default mode, and central executive networks). Forty-five phase-locked functional connectivity features across the theta, alpha, and beta frequency bands were subsequently extracted. A three-stage feature selection method (random forest importance ranking, Pearson correlation redundancy removal, exhaustive search to determine optimal subsets) was employed to screen key neural biomarkers. Four classification models - logistic regression, support vector machines, random forest, and XGBoost - were constructed and compared. Ten-fold cross-validation and grid search were employed to optimize hyperparameters, with performance evaluated using accuracy, recall, precision, F1-score, and AUC-ROC. Finally, the SHAP framework was applied for model interpretability analysis, revealing the contributions and interactions of key brain network features. RESULTS: Diagnostic model: The XGBoost model demonstrated exceptional performance in distinguishing SCD patients from healthy controls (AUC of 0.994, accuracy of 96.7%). Core biomarkers primarily concentrated on connections within the dorsal attention network (DAN), salience network (SN), and sensorimotor network (SMN) across the beta and alpha frequency bands, with intra-DAN connections in the beta band contributing most significantly. SHAP interaction dependency analysis further revealed complex nonlinear interaction patterns that may underlie, including a "fork-collider" synergistic structure centered on beta-DAN and theta-SMN-DAN, cross-frequency inhibition of beta-DAN by alpha-SN, and dynamic gating of beta-DMN by alpha-SMN-DAN. The results of this study indicate that subclinical depression (ScD) manifests as a pattern of synergistic dysregulation involving multiple frequency bands and brain networks. In terms of predictive modeling, support vector machines (SVMs) performed best in predicting the response of ScD patients to exercise intervention, with baseline positive affect (PA) levels and functional connectivity between the somatosensory motor network (SMN) and the dorsal attentional network (DAN) in the beta-band identified as key predictors. Furthermore, the patterns of feature interactions revealed by the model provide a testable framework for understanding the underlying model-derived neurophysiological patterns of subclinical depression from the perspective of multi-frequency, multi-network dyssynchrony; however, these results should still be interpreted as statistical associations rather than direct evidence of biological causality. SHAP analysis revealed an interpretable integration pathway ("behavior-driven --> core coordination --> dynamic gating --> frequency band balance"), providing model-driven insights into the role of behavior-neural integration in personalized interventions. CONCLUSION: This study systematically elucidates for the first time the intricate model-derived neurophysiological patterns of subclinical depression at the multi-frequency brain network level. It confirms the substantial potential of EEG functional connectivity as an objective biomarker while providing an interpretable neurophysiological basis for the precise selection of exercise interventions. These findings deepen our understanding of the early pathophysiology of depression and lay a robust foundation for developing low-cost, non-invasive tools for early screening and personalized treatment decision-making. CI - Copyright (c) 2026 Peng, Chi, Yang, Ren, Li and Fan. FAU - Peng, Ting AU - Peng T AD - School of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China. FAU - Chi, Aiping AU - Chi A AD - School of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China. FAU - Yang, Jinghui AU - Yang J AD - School of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China. FAU - Ren, Yizhong AU - Ren Y AD - School of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China. FAU - Li, Yanru AU - Li Y AD - School of Physical Education, Shaanxi Normal University, Xi'an, Shaanxi, China. FAU - Fan, Jing AU - Fan J AD - Shaanxi Vocational and Technical College, Xi'an, Shaanxi, China. LA - eng PT - Journal Article DEP - 20260609 PL - Switzerland TA - Front Hum Neurosci JT - Frontiers in human neuroscience JID - 101477954 PMC - PMC13286898 OTO - NOTNLM OT - adolescents OT - depressive symptoms OT - diagnostic model OT - electroencephalography OT - machine learning OT - predictive model COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/25 06:37 MHDA- 2026/06/25 06:38 PMCR- 2026/06/09 CRDT- 2026/06/25 04:39 PHST- 2025/12/24 00:00 [received] PHST- 2026/04/28 00:00 [revised] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/06/25 06:38 [medline] PHST- 2026/06/25 06:37 [pubmed] PHST- 2026/06/25 04:39 [entrez] PHST- 2026/06/09 00:00 [pmc-release] AID - 10.3389/fnhum.2026.1774822 [doi] PST - epublish SO - Front Hum Neurosci. 2026 Jun 9;20:1774822. doi: 10.3389/fnhum.2026.1774822. eCollection 2026. PMID- 42344477 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260625 LR - 20260813 IS - 2691-3593 (Electronic) IS - 2691-3593 (Linking) VI - 7 IP - 2 DP - 2026 Jun TI - Patient-Reported Outcomes and Body Mass Index in Adolescents and Young Adults After Gender-Affirming Chest Surgery: A Single-Center Cross-Sectional Study. PG - e679 LID - 10.1097/AS9.0000000000000679 [doi] AB - OBJECTIVE: To assess the impact of body mass index (BMI) on patient-reported outcomes after gender-affirming chest surgery in adolescents. BACKGROUND: Despite most previous studies finding no association between BMI and patient-reported outcomes in adults undergoing gender-affirming chest surgery, BMI eligibility requirements remain widely used. Moreover, little data exists regarding the impact of BMI on these outcomes in adolescents. METHODS: A cross-sectional, patient-reported outcome survey study was conducted at a pediatric hospital from April to July 2024. Eligible individuals were at least 1-year postoperative from gender-affirming chest surgery. The primary outcome was the effect of BMI on scores from 7 validated patient-reported outcome measures, including BODY-Q Chest and Nipple, Gender Congruence and Life Satisfaction, Satisfaction with Decision, and Decision Regret Scale, compared between adolescent and young adult cohorts. RESULTS: Among 77 participants who completed the survey, 42 (54.5%) underwent surgery as adolescents and 35 (45.5%) as young adults. Patient-reported outcomes evaluating appearance satisfaction, psychosocial well-being, and decisional satisfaction were high, whereas decisional regret was low. Scores did not significantly differ between adolescent and young adult cohorts, and most patient-reported outcome measures were not significantly influenced by BMI. CONCLUSION: After gender-affirming chest surgery, both adolescents and young adults reported high appearance satisfaction, psychosocial well-being, and decisional satisfaction, along with low decisional regret. For the majority of patient-reported outcomes, these positive results were not associated with BMI, suggesting that gender-affirming chest surgery is associated with high quality of life for adolescents and young adults regardless of BMI. CI - Copyright (c) 2026 The Author(s). Published by Wolters Kluwer Health, Inc. FAU - Haley, Caleb AU - Haley C AD - From the Section of Plastic Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI. AD - National Clinician Scholars Program, Institute for Healthcare Policy and Innovation, University of Michigan, Ann Arbor, MI. FAU - Younoszai, Maya AU - Younoszai M AD - Division of Plastic Surgery, Seattle Children's Hospital, Seattle, WA. FAU - Roblee, Cole V AU - Roblee CV AD - Department of Surgery, Swedish Medical Center, Seattle, WA. FAU - Haugen, Peter AU - Haugen P AD - Division of Plastic Surgery, Seattle Children's Hospital, Seattle, WA. FAU - Araya-Colvin, Justine AU - Araya-Colvin J AD - Division of Plastic Surgery, Seattle Children's Hospital, Seattle, WA. FAU - Brydges, Hilliard T AU - Brydges HT AD - Division of Plastic Surgery, Department of Surgery, University of Washington Medical Center, Seattle, WA. FAU - Nguyen, Alisha AU - Nguyen A AD - Elson S. Floyd College of Medicine, Washington State University, Spokane, WA. FAU - Tople, Tannon AU - Tople T AD - University of Minnesota Twin Cities School of Medicine, Minneapolis, MN. FAU - Faino, Anna V AU - Faino AV AD - Core for Biostatistics, Epidemiology and Analytics in Research, Seattle Children's Research Institute, Seattle Children's Hospital, Seattle, WA. FAU - Gopalan, Maya AU - Gopalan M AD - Division of Plastic Surgery, Seattle Children's Hospital, Seattle, WA. FAU - Eble, Danielle AU - Eble D AD - Division of Plastic Surgery, Department of Surgery, Oregon Health & Science University, Portland, OR. FAU - Ettinger, Russell E AU - Ettinger RE AD - Division of Plastic Surgery, Seattle Children's Hospital, Seattle, WA. AD - Division of Plastic Surgery, Department of Surgery, University of Washington Medical Center, Seattle, WA. FAU - Morrison, Shane D AU - Morrison SD AD - Division of Plastic Surgery, Seattle Children's Hospital, Seattle, WA. AD - Division of Plastic Surgery, Department of Surgery, University of Washington Medical Center, Seattle, WA. AD - Department of Urology, University of Washington Medical Center, Seattle, WA. LA - eng PT - Journal Article DEP - 20260527 PL - United States TA - Ann Surg Open JT - Annals of surgery open : perspectives of surgical history, education, and clinical approaches JID - 101769928 PMC - PMC13290217 OTO - NOTNLM OT - adolescents OT - body mass index OT - gender-affirming surgery OT - obesity OT - patient-reported outcomes COIS- Disclosure: The authors declare that they have nothing to disclose. EDAT- 2026/06/25 06:36 MHDA- 2026/06/25 06:37 PMCR- 2026/05/27 CRDT- 2026/06/25 04:39 PHST- 2026/01/23 00:00 [received] PHST- 2026/04/25 00:00 [accepted] PHST- 2026/06/25 06:37 [medline] PHST- 2026/06/25 06:36 [pubmed] PHST- 2026/06/25 04:39 [entrez] PHST- 2026/05/27 00:00 [pmc-release] AID - AOSO-D-26-00020 [pii] AID - 10.1097/AS9.0000000000000679 [doi] PST - epublish SO - Ann Surg Open. 2026 May 27;7(2):e679. doi: 10.1097/AS9.0000000000000679. eCollection 2026 Jun. PMID- 42344264 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - The mediating role of perceived physical literacy in the relationship between physical activity and cardiorespiratory fitness among Spanish adolescents: the ENERGYCO Study. PG - 1823971 LID - 10.3389/fpubh.2026.1823971 [doi] LID - 1823971 AB - BACKGROUND: Physical literacy (PL) may help explain the variability in health benefits associated with physical activity (PA) during adolescence. However, evidence examining the mediating role of perceived PL in the relationship between PA and cardiorespiratory fitness (CRF) in adolescents is scarce. OBJECTIVE: To examine whether perceived PL mediates the association between PA and indirectly estimated CRF based on a field test in adolescents. METHODS: Cross-sectional analyses were conducted using baseline data from the ENERGY expenditure of COmmuting to school study (ENERGYCO), which included 273 Spanish adolescents (median: 14.3 years; IQR: 2.1; 46.9% girls in the full sample [n = 273] and 47.7% girls in the analytical sample [n = 262]), 262 of whom had complete data for PA and perceived PL. Perceived PL was assessed via the Spanish Physical Literacy Perception Instrument for Adolescents (S-PPLI; Cronbach's alpha = 0.85). PA was assessed via the Spanish Youth Activity Profile (YAP-S). CRF was assessed via the 20-m shuttle run test and estimated maximum oxygen consumption (VO(2)max). Associations were examined via Spearman correlations and mediation analyses adjusted for sex, years from peak height velocity, body mass index (BMI), and socioeconomic status. RESULTS: Mediation analyses showed a significant indirect effect of PA on VO(2)max through perceived PL (indirect effect = 0.61, 95% bias-corrected and accelerated confidence interval (BCa CI: 0.14-1.16), accounting for 54.2% of the total effect. In domain-specific analyses, communication with others (indirect effect = 0.38, 95% BCa CI: 0.05-0.77) and knowledge and understanding (indirect effect = 0.60, 95% BCa CI: 0.17-1.08) significantly mediated the PA-VO(2)max association, whereas no significant mediation was observed for the sense of self and self-confidence domain (indirect effect = 0.27, 95% BCa CI: -0.08 to 0.68). CONCLUSION: Perceived PL mediated the association between PA and CRF in adolescents. These findings support an indirect pathway linking PA to aerobic fitness through perceived PL, although causal inferences cannot be drawn because of the cross-sectional design. CI - Copyright (c) 2026 Valle-Munoz, Jaakkola, Lopez-Gil and Villa-Gonzalez. FAU - Valle-Munoz, Victor Manuel AU - Valle-Munoz VM AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. FAU - Jaakkola, Timo AU - Jaakkola T AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Ecuador. AD - Faculty of Health Sciences, Universidad Autonoma de Chile, Temuco, Chile. FAU - Villa-Gonzalez, Emilio AU - Villa-Gonzalez E AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. LA - eng PT - Journal Article DEP - 20260609 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Cardiorespiratory Fitness/physiology/psychology MH - Female MH - Spain MH - Adolescent MH - Cross-Sectional Studies MH - Male MH - *Exercise/psychology/physiology MH - *Health Literacy/statistics & numerical data PMC - PMC13287042 OTO - NOTNLM OT - adolescence OT - cardiorespiratory fitness OT - health OT - physical activity OT - physical literacy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/25 06:37 MHDA- 2026/06/25 06:38 PMCR- 2026/06/09 CRDT- 2026/06/25 04:37 PHST- 2026/03/05 00:00 [received] PHST- 2026/05/02 00:00 [revised] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/06/25 06:38 [medline] PHST- 2026/06/25 06:37 [pubmed] PHST- 2026/06/25 04:37 [entrez] PHST- 2026/06/09 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1823971 [doi] PST - epublish SO - Front Public Health. 2026 Jun 9;14:1823971. doi: 10.3389/fpubh.2026.1823971. eCollection 2026. PMID- 42343872 OWN - NLM STAT- MEDLINE DCOM- 20260703 LR - 20260717 IS - 1651-2006 (Electronic) IS - 1401-7431 (Linking) VI - 60 IP - 1 DP - 2026 Dec TI - A novel risk score based on exercise capacity to predict prognosis in adults with congenital heart disease. PG - 2690782 LID - 10.1080/14017431.2026.2690782 [doi] AB - BACKGROUND: Exercise capacity (EC) is a key prognostic indicator in adults with congenital heart disease (ACHD), closely associated with all-cause mortality. Thus, EC may serve a valuable tool for risk-stratification in ACHD. We propose a novel risk score incorporating EC, age, and lesion complexity to improve mortality risk prediction in ACHD. METHODS: This observational study utilized data from the Swedish National Register of Congenital Heart Disease. Adults aged 18 to 60 years who had completed at least one bicycle ergometer exercise test were included. EC was classified according to percentage of predicted capacity (% ECpred): normal (>70%), moderately impaired (50-70%), severely impaired (<50%). Patients were followed for ten years or until death. Odds ratios for mortality were used to derive a 5-point risk-score to estimate 10-year mortality, with the following point allocation: % ECpred 50-70 = 1 point, <50% = 2 points; age 25-40 years = 1 point, 40-60 years = 2 points; moderate/severe lesion complexity = 1 point. Internal validation of risk score resulted in a median AUC of 0.72 for training data, and 0.70 for test data. RESULTS: In total, 1,525 patients (mean age 31.1 +/- 11.8 years; 44% women) were included, where 104 deaths occurred during follow-up. Risk scores ranged from 0 to 5, corresponding to 10-year mortality rates of 1%, 3%, 5%, 10%, 18%, and 34%, respectively. CONCLUSION: A simple risk score incorporating exercise capacity, age, and congenital heart lesion complexity can effectively stratify ACHD patients to 10-year risk of all-cause mortality following an exercise test. FAU - Dalman-Skogby, Sandra AU - Dalman-Skogby S AD - Department of Diagnostics and Intervention, Umea Universitet, Umea, Sweden. AD - Region Vastra Gotaland, Sahlgrenska University Hospital, Children's Heart Center, Gothenburg, Sweden. FAU - Wiklund, Urban AU - Wiklund U AD - Department of Diagnostics and Intervention, Biomedical Engineering and Radiation Physics, Umea University, Umea, Sweden. FAU - Wikner, Anna AU - Wikner A AD - Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden. FAU - Rinnstrom, Daniel AU - Rinnstrom D AD - Department of Diagnostics and Intervention, Umea Universitet, Umea, Sweden. FAU - Christersson, Christina AU - Christersson C AD - Department of Medical Sciences, Cardiology, Uppsala University, Sweden. FAU - Sorensson, Peder AU - Sorensson P AD - Department of Cardiology, Karolinska University Hospital, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden. FAU - Trzebiatowska-Krzynska, Aleksandra AU - Trzebiatowska-Krzynska A AD - Department of Cardiology and Department of Medicine and Health Sciences, Linkoping University, Linkoping, Sweden. FAU - Mandalenakis, Zacharias AU - Mandalenakis Z AD - Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Hlebowicz, Joanna AU - Hlebowicz J AD - Department of Cardiology, Skane University Hospital, Lund, Sweden. AD - Department of Clinical Science, Lund University, Lund, Sweden. FAU - Sandberg, Camilla AU - Sandberg C AD - Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden. AD - Department of Community Health and Rehabilitation, Umea University, Umea, Sweden. FAU - Johansson, Bengt AU - Johansson B AUID- ORCID: 0000-0003-0976-6910 AD - Department of Diagnostics and Intervention, Umea Universitet, Umea, Sweden. LA - eng PT - Journal Article PT - Observational Study DEP - 20260703 PL - England TA - Scand Cardiovasc J JT - Scandinavian cardiovascular journal : SCJ JID - 9708377 SB - IM MH - Humans MH - *Heart Defects, Congenital/physiopathology/mortality/diagnosis MH - *Exercise Tolerance MH - Adult MH - Risk Assessment MH - Female MH - Middle Aged MH - *Exercise Test MH - Predictive Value of Tests MH - Prognosis MH - Sweden MH - Male MH - Registries MH - Young Adult MH - Adolescent MH - Time Factors MH - Age Factors MH - Risk Factors MH - *Decision Support Techniques MH - Reproducibility of Results MH - Odds Ratio MH - Severity of Illness Index MH - Area Under Curve OTO - NOTNLM OT - Congenital OT - exercise test OT - exercise tolerance OT - heart defects OT - mortality OT - risk assessment EDAT- 2026/06/25 06:36 MHDA- 2026/07/03 16:10 CRDT- 2026/06/25 04:22 PHST- 2026/07/03 16:10 [medline] PHST- 2026/06/25 06:36 [pubmed] PHST- 2026/06/25 04:22 [entrez] AID - 10.1080/14017431.2026.2690782 [doi] PST - ppublish SO - Scand Cardiovasc J. 2026 Dec;60(1):2690782. doi: 10.1080/14017431.2026.2690782. Epub 2026 Jul 3. PMID- 42343553 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260911 IS - 1437-4331 (Electronic) IS - 1434-6621 (Linking) VI - 64 IP - 10 DP - 2026 Sep 25 TI - Performance of the European Kidney Function Consortium (EKFC) creatinine-based eGFR equation and other eGFR equations in a north European population. A multicentre study in Norway. PG - 2207-2215 LID - 10.1515/cclm-2026-0464 [doi] AB - OBJECTIVES: Accurate estimation of glomerular filtration rate (eGFR) is necessary for early detection and staging of chronic kidney disease (CKD), risk stratification, and guiding therapies that prevent complications and progression to advanced CKD. This study aimed to evaluate the performance of different eGFR equations in a large national cohort. METHODS: This multicentre study was conducted at six university hospitals in Norway. Retrospective data from patient's medical records from 2005 to 2024 for 5,552 adults and 2,981 children were used to validate several creatinine-based eGFR equations against measured GFR (mGFR) by Iohexol clearance. Performance was assessed using median bias and P30 accuracy (proportion of eGFR within +/-30 % of mGFR). RESULTS: The European Kidney Function Consortium (EKFC) creatinine-based eGFR equation outperformed the CKD-EPI 2009 and 2021, the Modification of Diet in Renal Disease (MDRD) in adults, the Schwarts bedside and the CKiD U25 equations in children >/=2 years and was comparable to the Lund-Malmo equation (LM) in adults. Both CKD-EPI equations had the lowest accuracy and were overestimating GFR in young people (<25 years) and elderly patients (>/=65 years). Replacing the CKD-EPI equations with the EKFC equation will result in lower eGFR values and a higher prevalence of CKD stages 3-5. Replacing the LM and MDRD with the EKFC equation will result in higher eGFR and a lower prevalence of CKD stages 3-5. CONCLUSIONS: The EKFC equation was overall the best suited creatinine-based eGFR equation for this Norwegian population from 2 years of age. Clinicians should be informed about clinical implications of shifting from other equations to the EKFC equation. CI - (c) 2026 the author(s), published by De Gruyter, Berlin/Boston. FAU - Averina, Maria AU - Averina M AUID- ORCID: 0000-0003-0195-1871 AD - Department of Laboratory Medicine, University Hospital of North Norway (UNN), Tromso, Norway. AD - Department of Clinical Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromso, Norway. FAU - Brun, Atle AU - Brun A AD - Department of Medical Biochemistry and Pharmacology, Haukeland University Hospital, Bergen, Norway. FAU - Skadberg, Oyvind AU - Skadberg O AD - Laboratory of Clinical Biochemistry, Stavanger University Hospital, Stavanger, Norway. FAU - Lofblad, Lena AU - Lofblad L AD - Department of Medical Biochemistry, Laboratory Clinic, St. Olavs Hospital, Trondheim, Norway. AD - Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway. FAU - Michaelsen, Anette AU - Michaelsen A AD - Department of Laboratory Medicine, University Hospital of North Norway (UNN), Tromso, Norway. FAU - Bergan, Stein AU - Bergan S AD - Department of Pharmacology, Oslo University Hospital, Oslo, Norway. FAU - Asberg, Anders AU - Asberg A AD - Department of Transplantation Medicine, Division of Surgery and Specialized Medicine, Oslo University Hospital, Rikshospitalet, Oslo, Norway. AD - Department of Pharmacy, University of Oslo, Oslo, Norway. FAU - Lien, Mads Roald AU - Lien MR AD - Department of Medical Biochemistry, Laboratory Medicine Clinic, Oslo University Hospital, Oslo, Norway. FAU - Melsom, Toralf AU - Melsom T AD - Department of Clinical Medicine, Faculty of Health Sciences, UiT, The Arctic University of Norway, Tromso, Norway. AD - Department of Nephrology, University Hospital of North Norway (UNN), Tromso, Norway. FAU - Eide, Ivar Anders AU - Eide IA AD - Department of Kidney Medicine, Akershus University Hospital, Oslo, Norway. AD - Division of Medicine and Laboratory Sciences, University of Oslo, Oslo, Norway. FAU - Keil, Thomas Morten AU - Keil TM AD - Department of Nuclear Medicine, St. Olavs Hospital, Trondheim, Norway. FAU - Skrunes, Rannveig AU - Skrunes R AD - Department of Medicine, Section of Nephrology, Haukeland University Hospital, Bergen, Norway. FAU - Nome, Ragnhild Veline AU - Nome RV AD - Department of Medical Biochemistry, Laboratory Medicine Clinic, Oslo University Hospital, Oslo, Norway. FAU - Vethe, Nils Tore AU - Vethe NT AD - Department of Pharmacology, Oslo University Hospital, Oslo, Norway. AD - Department of Pharmacy, University of Oslo, Oslo, Norway. FAU - Sithiravel, Cindhya AU - Sithiravel C AD - Department of Laboratory Medicine, Akershus University Hospital, Oslo, Norway. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260626 PL - Germany TA - Clin Chem Lab Med JT - Clinical chemistry and laboratory medicine JID - 9806306 RN - AYI8EX34EU (Creatinine) SB - IM MH - Humans MH - *Glomerular Filtration Rate MH - *Creatinine/blood MH - Norway MH - Female MH - Male MH - Adult MH - Child MH - Retrospective Studies MH - Aged MH - Middle Aged MH - Adolescent MH - *Renal Insufficiency, Chronic/diagnosis/physiopathology MH - Child, Preschool MH - Young Adult MH - *Kidney Function Tests MH - Aged, 80 and over OTO - NOTNLM OT - CKD-EPI OT - European Kidney Function Consortium (EKFC) OT - Iohexol OT - Lund-Malmo OT - Modification of Diet in Renal Disease (MDRD) OT - eGFR EDAT- 2026/06/25 06:35 MHDA- 2026/08/27 17:35 CRDT- 2026/06/25 01:03 PHST- 2026/03/24 00:00 [received] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/08/27 17:35 [medline] PHST- 2026/06/25 06:35 [pubmed] PHST- 2026/06/25 01:03 [entrez] AID - cclm-2026-0464 [pii] AID - 10.1515/cclm-2026-0464 [doi] PST - epublish SO - Clin Chem Lab Med. 2026 Jun 26;64(10):2207-2215. doi: 10.1515/cclm-2026-0464. Print 2026 Sep 25. PMID- 42343262 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260916 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 24 TI - Agreement between random upper arm circumference and standard mid-upper arm circumference for identifying acute malnutrition among children aged 6-59 months in Southwest Ethiopia. LID - 10.1186/s12887-026-07125-6 [doi] LID - 851 AB - BACKGROUND: Mid-Upper Arm Circumference (MUAC) is a widely used, rapid, and low-cost anthropometric tool for community-based screening of acute malnutrition among children. However, accurate MUAC assessment requires identification of the midpoint of the upper arm and proper tape placement, which may contribute to inter-observer variability and inconsistencies in field measurements. Random Upper Arm Circumference (RUAC) has been proposed as a simpler alternative for community screening. Nevertheless, evidence regarding the agreement and validity of RUAC compared with standard MUAC for identifying wasting among Ethiopian children remains limited. Therefore, this study aimed to assess the concordance and validity of RUAC compared with MUAC in identifying wasting among children aged 6-59 months in Southwest Ethiopia. METHODS: A community-based cross-sectional study was conducted among 591 children aged 6-59 months in Southwest Ethiopia from June 2 to June 30, 2023. Participants were selected using simple random sampling from child registration lists used as the sampling frame. Paired RUAC and standard MUAC measurements were obtained from each child to assess agreement between the two methods. Children were classified as wasted using the MUAC cut-off value of < 12.5 cm, and RUAC was categorized using the same threshold. Data were analyzed using SPSS version 26. Agreement between RUAC and MUAC was evaluated using Cohen's Kappa for categorical measures and Bland-Altman analysis for continuous measurements. Diagnostic performance was assessed using sensitivity, specificity, positive predictive value, negative predictive value, and receiver operating characteristic (ROC) curve analysis. Assumptions for statistical analyses were checked before analysis. RESULTS: Among the participants, 61 (10.4%) children were classified as wasted using standard MUAC measurements. Significant agreement was observed between RUAC and standard MUAC classifications (kappa = 0.69; 95% CI: 0.60-0.79; p < 0.001). Using standard MUAC as the reference method, RUAC demonstrated a sensitivity of 81.6% (95% CI: 71.9%-89.0%) and specificity of 95.2% (95% CI: 93.1%-96.9%) for identifying wasting among children aged 6-59 months. The positive predictive value and negative predictive value of RUAC were 66.2% (95% CI: 55.0%-76.2%) and 97.8% (95% CI: 96.1%-98.9%), respectively. RUAC also demonstrated excellent diagnostic performance, with an area under the curve of 0.99 (95% CI: 0.98-0.99) for severe acute malnutrition and 0.94 (95% CI: 0.93-0.96) for moderate acute malnutrition. CONCLUSION: RUAC showed substantial agreement with standard MUAC and acceptable diagnostic performance for identifying wasting among children aged 6-59 months in Southwest Ethiopia. However, the evidence is limited to a single-site cross-sectional study, therefore, generalization beyond the study population is not justified. Further validation across different Ethiopian settings is recommended. CI - (c) 2026. The Author(s). FAU - Husen, Anuwar AU - Husen A AD - Masha Health Center, Sheka Zone, Southwest, Ethiopia. AD - Department of Nutrition and Dietetics, Faculty of Public Health, Institute of Health, Jimma University, Jimma, Ethiopia. FAU - Berhane, Anteneh AU - Berhane A AUID- ORCID: 0000-0001-5078-8703 AD - School of Public Health, College of Health and Medical Sciences, Haramaya University, Harer, Ethiopia. antishaction@gmail.com. FAU - Teshome, Melese Sinaga AU - Teshome MS AD - Department of Nutrition and Dietetics, Faculty of Public Health, Institute of Health, Jimma University, Jimma, Ethiopia. AD - Rehabilitation Research Centre (REVAL), Rehabilitation Sciences and Physiotherapy, Hasselt University, Wetenschapspark 7, Diepenbeek, 3590, Belgium. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260624 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Ethiopia MH - *Arm/anatomy & histology MH - Infant MH - Child, Preschool MH - Cross-Sectional Studies MH - Male MH - Female MH - *Anthropometry/methods MH - Reproducibility of Results MH - *Wasting Syndrome/diagnosis MH - Sensitivity and Specificity MH - Mass Screening/methods MH - Acute Disease PMC - PMC13560134 OTO - NOTNLM OT - Concordance OT - Correlation OT - Ethiopia OT - Mid-upper arm circumference OT - Random upper arm circumference OT - Validity OT - Wasting COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and its later amendments. Ethical approval was obtained from the Institutional Review Board of Jimma University, Institute of Health (reference number JUIH/IRB/501/23). Permission to conduct the study was also obtained from the relevant local health authorities. Written informed consent was obtained from the legal guardians of all participating children to data collection. Participation was entirely voluntary, and caregivers were informed of their right to withdraw from the study at any time without any consequences. Confidentiality of the collected information was ensured by assigning anonymized identification codes and restricting data access to the research team only. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/25 06:37 MHDA- 2026/09/10 05:37 PMCR- 2026/06/24 CRDT- 2026/06/25 00:25 PHST- 2026/03/06 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/09/10 05:37 [medline] PHST- 2026/06/25 06:37 [pubmed] PHST- 2026/06/25 00:25 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.1186/s12887-026-07125-6 [pii] AID - 7125 [pii] AID - 10.1186/s12887-026-07125-6 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 24;26(1):851. doi: 10.1186/s12887-026-07125-6. PMID- 42343232 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260911 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jun 25 TI - Predicting the risk of unplanned cesarean delivery at admission to guide labor process management: a retrospective cohort study in Southwest China. LID - 10.1186/s12884-026-09470-x [doi] LID - 1001 AB - BACKGROUND: Following the implementation of the three-child policy in China, an increasing number of pregnant people prefer vaginal delivery over cesarean delivery. However, concerns about unplanned cesarean delivery during labor have increased the demand for a quantitative risk assessment tool. Therefore, developing a prediction model tailored for pregnant Chinese people is essential for assisting clinical decision-making. OBJECTIVE: This study aimed to identify risk factors associated with unplanned cesarean delivery during a trial of labor and to develop a predictive model for determining this risk at admission. METHODS: This single-center retrospective cohort study analyzed 1,532 pregnant people with a term, singleton, cephalic pregnancy without a history of uterine surgery who were admitted for a trial of labor (April-December 2021). Of these, 138 underwent unplanned cesarean delivery and 1,394 achieved vaginal delivery. Predictors were selected via LASSO regression from an initial set of 13 candidate variables and used to build a multivariate logistic nomogram. The model was assessed by its AUC, sensitivity, specificity, accuracy, positive predictive value, negative predictive value and calibration (Hosmer-Lemeshow test). Clinical utility was evaluated via decision curve analysis, and internal validation was conducted via 1,000 bootstrap repetitions. RESULTS: Eight variables were identified as significant predictors of delivery mode: maternal height, maternal BMI, history of vaginal delivery, Bishop score at admission, premature rupture of membranes, gestational age, complications, and estimated fetal weight. The predictive model achieved an AUC of 0.811 (95% CI: 0.774-0.848). The Hosmer-Lemeshow test indicated P = 0.513. Internal validation yielded a mean AUC of 0.804 and a Brier score of 0.071, demonstrating good discrimination and calibration. CONCLUSION: A nomogram-based predictive model was developed to assess the risk of unplanned cesarean delivery during trial of labor. This model provides a quantitative tool to guide clinicians in risk assessment and optimize labor management, potentially reducing complications associated with unplanned cesarean deliveries. CI - (c) 2026. The Author(s). FAU - Yang, Zhuo AU - Yang Z AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Zhang, Huicong AU - Zhang H AD - Whiting School of Engineering, Johns Hopkins University, Baltimore, USA. FAU - Zheng, Yue AU - Zheng Y AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Chang, Shufang AU - Chang S AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Sun, Jiangchuan AU - Sun J AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. sunjiangchuan@126.com. LA - eng PT - Journal Article DEP - 20260625 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Retrospective Studies MH - *Cesarean Section/statistics & numerical data MH - China MH - Adult MH - *Trial of Labor MH - Risk Factors MH - Risk Assessment/methods MH - Nomograms PMC - PMC13555930 OTO - NOTNLM OT - Clinical decision-making OT - LASSO regression OT - Nomogram OT - Predictive factors OT - Risk prediction model OT - Unplanned cesarean delivery OT - Vaginal trial of labor COIS- Declarations. Ethics approval and consent to participate: The Ethics Committee of the Second Affiliated Hospital of Chongqing Medical University approved this study and waived the need for informed consent because of the retrospective nature of this study. The research was conducted according to the ethical standard of the Helsinki Declaration, and the patient data were stored anonymously in a dedicated database. All methods were carried out in accordance with relevant guidelines and regulations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/25 06:38 MHDA- 2026/09/09 07:07 PMCR- 2026/06/25 CRDT- 2026/06/25 00:24 PHST- 2025/09/09 00:00 [received] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/09/09 07:07 [medline] PHST- 2026/06/25 06:38 [pubmed] PHST- 2026/06/25 00:24 [entrez] PHST- 2026/06/25 00:00 [pmc-release] AID - 10.1186/s12884-026-09470-x [pii] AID - 9470 [pii] AID - 10.1186/s12884-026-09470-x [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jun 25;26(1):1001. doi: 10.1186/s12884-026-09470-x. PMID- 42342487 OWN - NLM STAT- Publisher LR - 20260727 IS - 1558-075X (Electronic) IS - 0146-0005 (Linking) VI - 50 IP - 5 DP - 2026 Aug TI - Standardizing outcome measures in preterm infant nutrition research: Use of anthropometry and body composition in the neonatal intensive care unit. PG - 152271 LID - S0146-0005(26)00060-1 [pii] LID - 10.1016/j.semperi.2026.152271 [doi] AB - Nutritional care and growth patterns in the neonatal intensive care unit (NICU) can impact lifelong health. Standardized measurement and reporting of growth outcomes are critical to improve the quality of information generated in research and population surveillance, facilitate comparisons and meta-analyses across individual studies, and strengthen the evidence used to generate clinical practice recommendations. Anthropometrics, specifically weight, length, and head circumference, are feasible and practical methods to monitor nutritional status. For research purposes, we recommend these anthropometrics be measured at birth (as a measure of fetal growth), 28 days old (to assess short-term growth), and 36 weeks postmenstrual age (PMA) (to determine the postnatal growth pattern in the NICU). We also encourage recording number of days to regain birthweight as a measure of short-term growth. Research publications should describe clearly the methods used to measure anthropometrics and reference curves used to calculate z-scores. Body composition is a complementary marker of nutritional status, but currently validated techniques have practical limitations in the NICU. When body composition tools are available, fat-free mass and fat mass should be measured at approximately 36 weeks PMA. We also describe key knowledge gaps and research priorities regarding growth patterns of preterm infants in the NICU. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Bell, Katherine A AU - Bell KA AD - Division of Newborn Medicine, Department of Pediatrics, Brigham and Women's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA. Electronic address: kbell7@bwh.harvard.edu. FAU - Calkins, Kara L AU - Calkins KL AD - Division of Neonatology, Department of Pediatrics, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA. FAU - Gollins, Laura A AU - Gollins LA AD - Department of Pediatrics, Division of Neonatology, Texas Children's Hospital, Houston, TX, USA. FAU - McNelis, Kera AU - McNelis K AD - Division of Neonatology, Department of Pediatrics, Emory University, Children's Healthcare of Atlanta, Atlanta, GA, USA. FAU - Strobel, Katie M AU - Strobel KM AD - Division of Neonatology, Department of Pediatrics, University of Washington, Seattle, WA, USA. LA - eng PT - Journal Article PT - Review DEP - 20260624 PL - United States TA - Semin Perinatol JT - Seminars in perinatology JID - 7801132 SB - IM OTO - NOTNLM OT - Anthropometrics OT - Body composition OT - Growth OT - Infant OT - Malnutrition OT - Neonate OT - Preterm COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Katherine Bell reports a relationship with National Institute of Child Health and Human Development that includes: funding grants. Katherine Bell reports a relationship with Allen Foundation Inc that includes: funding grants. Katie Strobel reports a relationship with National Institute of Child Health and Human Development that includes: funding grants. Katie Strobel reports a relationship with Gerber Foundation that includes: funding grants. Katie Strobel reports a relationship with University of Washington Nutrition Obesity Research Center that includes: funding grants. Katie Strobel reports a relationship with Robert W. Anderson Endowed Fund that includes: funding grants. Katie Strobel reports a relationship with NEC Society that includes: funding grants. Kera McNelis reports a relationship with National Institute of Diabetes and Digestive and Kidney Diseases that includes: funding grants. Kera McNelis reports a relationship with ELGAN Study (site PI) that includes: funding grants and travel reimbursement. Kara Calkins reports a relationship with Fresenius Kabi USA LLC that includes: consulting or advisory and funding grants. Kara Calkins reports a relationship with Mead Johnson Nutrition Company that includes: consulting or advisory, funding grants, and speaking and lecture fees. Kara Calkins reports a relationship with Baxter International Inc that includes: consulting or advisory. Kara Calkins reports a relationship with Premier Research that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/25 00:33 MHDA- 2026/06/25 00:33 CRDT- 2026/06/24 21:55 PHST- 2026/05/11 00:00 [received] PHST- 2026/06/09 00:00 [revised] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/06/25 00:33 [pubmed] PHST- 2026/06/25 00:33 [medline] PHST- 2026/06/24 21:55 [entrez] AID - S0146-0005(26)00060-1 [pii] AID - 10.1016/j.semperi.2026.152271 [doi] PST - ppublish SO - Semin Perinatol. 2026 Aug;50(5):152271. doi: 10.1016/j.semperi.2026.152271. Epub 2026 Jun 24. PMID- 42341672 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260828 IS - 1096-7206 (Electronic) IS - 1096-7192 (Linking) VI - 148 IP - 4 DP - 2026 Aug TI - Ketogenic diet therapy in pyruvate dehydrogenase deficiency: Global clinical practice from literature and survey data. PG - 110190 LID - S1096-7192(26)00473-7 [pii] LID - 10.1016/j.ymgme.2026.110190 [doi] AB - BACKGROUND: Pyruvate dehydrogenase deficiency (PDHD) is a rare mitochondrial disorder characterized by impaired carbohydrate metabolism, resulting in lactic acidosis and neurological dysfunction. Ketogenic diet therapy (KDT) is commonly used to bypass defective glucose metabolism; however, evidence guiding clinical practice remains limited. OBJECTIVE: To evaluate global clinical practice and published evidence regarding the use of KDT in children and young people with PDHD. METHODS: A combined literature review and international clinician survey were conducted. A systematic search identified studies reporting KDT use in PDHD. Two international surveys targeting registered dietitians and medical doctors collected data on clinical practice, diet initiation, monitoring, outcomes, and adverse effects. RESULTS: Forty studies describing 129 patients were identified, predominantly case reports or series. Survey responses were obtained from 41 dietitians (142 patients) and 14 physicians (64 patients) across multiple regions. All physician respondents supported referral for KDT at diagnosis regardless of genotype. Classical ketogenic diets were most commonly prescribed, though modified approaches were frequently used in clinical practice to improve feasibility and palatability. Target beta-hydroxybutyrate levels typically ranged between 2 and 4 mmol/L, although treatment was frequently individualized. Findings demonstrated improvements in seizure control, motor function, cognition, and quality of life. Adverse effects were primarily gastrointestinal. CONCLUSIONS: KDT is a widely used and generally well tolerated therapeutic strategy for PDHD across genotypes and age groups, with reported clinical benefits extending beyond seizure control. Clinical practice demonstrates variability, reflecting the limited high-quality evidence base. Development of standardized but flexible clinical guidelines and further longitudinal studies are needed to optimize patient outcomes. CI - Crown Copyright (c) 2026. Published by Elsevier Inc. All rights reserved. FAU - Madsen, Sarianne AU - Madsen S AD - UCSF Benioff Children's Hospital San Francisco, 1825 Fourth Street, Fifth Floor, 5A, San Francisco, CA 94158, USA. Electronic address: sarianne.madsen@ucsf.edu. FAU - Allender, Brooke AU - Allender B AD - The Royal Children's Hospital Melbourne, Lemington Rd, Parkville, VIC 3052, Australia. Electronic address: brooke.allender@rch.org.au. FAU - Blackford, Robyn AU - Blackford R AD - Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E Chicago Ave, Box 29, Chicago, IL 60611, USA. Electronic address: rblackford@luriechildrens.org. FAU - Bollard, Tessa AU - Bollard T AD - Sydney Children's Hospital, Randwick, High Street, Randwick 2031, NSW, Australia. Electronic address: tessa.bollard@health.nsw.gov.au. FAU - Comerford, Annabel AU - Comerford A AD - Women's and Children's Health Network, 72 King William Road, North Adelaide, South Australia, Australia 5006. Electronic address: annabel.comerford@sa.gov.au. FAU - Johnson, Meredith L AU - Johnson ML AD - Children's Healthcare of Atlanta, 1001 Johnson Ferry Road NE, Atlanta, GA 30342, USA. Electronic address: meredith.johnson2@choa.org. FAU - Sinha, Rachel AU - Sinha R AD - The Royal Children's Hospital Melbourne, Lemington Rd, Parkville, VIC 3052, Australia. Electronic address: rachel.sinha@rch.org.au. FAU - Vanatta, Lisa AU - Vanatta L AD - Barrow Neurological Institute at Phoenix Children's, 1919 E. Thomas Road, Phoenix, AZ 85016, USA. Electronic address: lvanatta@phoenixchildrens.com. FAU - Whiteley, Victoria J AU - Whiteley VJ AD - Royal Manchester Children's Hospital, Oxford Road, Manchester M13 9WL, UK. Electronic address: victoria.whiteley@mft.nhs.uk. FAU - Schoeler, Natasha E AU - Schoeler NE AD - UCL Great Ormond Street Institute of Child Health, University College London, Gower Street, London WC1E 6BT, UK; Great Ormond Street Hospital for Children, Great Ormond St, London WC1N 3JH, UK. Electronic address: n.schoeler@ucl.ac.uk. CN - Ketogenic Dietitians Research Network LA - eng PT - Journal Article PT - Systematic Review DEP - 20260618 PL - United States TA - Mol Genet Metab JT - Molecular genetics and metabolism JID - 9805456 SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - *Diet, Ketogenic/methods/adverse effects MH - *Pyruvate Dehydrogenase Complex Deficiency Disease/diet therapy MH - Surveys and Questionnaires MH - Treatment Outcome OTO - NOTNLM OT - Ketogenic diet therapy OT - Pyruvate dehydrogenase deficiency COIS- Declaration of competing interest SM received scholarship from Charlie Foundation to attend a conference. BA has received grants from Vitaflo and Metabolic Dietary Disorders Australia (NPO) to attend conferences. RB is a consultant to Nutricia North America and received scholarship from Charlie Foundation. TB received funding from Vitaflo Australia and Nutricia Advanced Medical Nutrition for accommodation and flights. AC has received grants from Nutricia Advanced Medical Nutrition and Vitaflo Australia. MLJ is a consultant to Ajinomoto Cambrooke and Nutricia North America and previously received scholarship from Charlie Foundation. RS has received grants from Nutricia Advanced Medical Nutrition and Vitaflo to attend conferences. LV previously received funding for research from Ajinomoto Cambrooke; Consultant to Nutricia North America; scholarship from Charlie Foundation; and honoraria from Keto Hope Foundation, Functional formularies, and Dr. Schaer. VJW has received grants from Nutricia Advanced Medical Nutrition, Vitaflo and Matthew's Friends Charity, and honoraria from Nutricia Advanced Medical Nutrition, Vitaflo, Dr. Schaer and Ajinomoto Cambrooke. NES was previously supported for a research post by Vitaflo. She has received grants from Nutricia Advanced Medical Nutrition, Vitaflo and Matthew's Friends Charity, and honoraria from Nutricia Advanced Medical Nutrition, Vitaflo, Dr. Schaer, Proveca and Grin Therapeutics Inc. EDAT- 2026/06/25 00:33 MHDA- 2026/07/16 12:40 CRDT- 2026/06/24 18:10 PHST- 2026/04/03 00:00 [received] PHST- 2026/05/30 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/07/16 12:40 [medline] PHST- 2026/06/25 00:33 [pubmed] PHST- 2026/06/24 18:10 [entrez] AID - S1096-7192(26)00473-7 [pii] AID - 10.1016/j.ymgme.2026.110190 [doi] PST - ppublish SO - Mol Genet Metab. 2026 Aug;148(4):110190. doi: 10.1016/j.ymgme.2026.110190. Epub 2026 Jun 18. PMID- 42341584 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260909 IS - 1873-3573 (Electronic) IS - 0039-9140 (Linking) VI - 311 DP - 2027 Jan 1 TI - Determination of multiclass contaminants in colostrum by HS-SPME-GC-MS/MS: method development and validation. PG - 130203 LID - S0039-9140(26)00859-3 [pii] LID - 10.1016/j.talanta.2026.130203 [doi] AB - Breast milk is the primary source of nutrition for newborns. In addition to its well-established nutritional and immunological benefits, breast milk may also serve as a pathway for exposure to environmental contaminants, including pesticides and pharmaceuticals and personal care products (PPCPs). In this context, colostrum is especially relevant because it is the first food consumed by neonates, who are highly vulnerable to chemical stressors due to their physiological immaturity. Early-life exposure to these compounds may affect the development of the neurological, endocrine, and immune systems. Therefore, the determination of these contaminants in colostrum is essential to better understand maternal and neonatal exposure. This study aimed to develop a method employing HS-SPME and GC-MS/MS for the determination of multiclass contaminants in colostrum. Under standardized extraction conditions, a polyacrylate fiber was used. The LODs of the method ranged from 0.15 to 0.76 ng mL(-1,) and the LOQs ranged from 0.5 to 2.5 ng mL(-1). Accuracy and precision showed recovery values ranging from 43 to 120%, with RSD <22% for all analytes. Of the 26 analyzed samples, 10 contained at least one detected analyte, including five parabens and atrazine. The proposed method proved to be accurate, precise, solvent-free, and suitable for monitoring contaminants in colostrum. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Meireles, Anna Carolina Nickel AU - Meireles ACN AD - Post-graduate Program in Technological and Environmental Chemistry, Escola de Quimica e Alimentos, Laboratorio de Analise de Compostos Organicos e Metais (LACOM), Universidade Federal do Rio Grande, Rio Grande, RS, 96201-900, Brazil. FAU - Barbosa, Sergiane Caldas AU - Barbosa SC AD - Post-graduate Program in Technological and Environmental Chemistry, Escola de Quimica e Alimentos, Laboratorio de Analise de Compostos Organicos e Metais (LACOM), Universidade Federal do Rio Grande, Rio Grande, RS, 96201-900, Brazil. FAU - Kupski, Larine AU - Kupski L AD - Post-graduate Program in Food Engineering and Science, Escola de Quimica e Alimentos, Laboratorio de Micotoxinas e Ciencias de Alimentos (LAMCA), Universidade Federal do Rio Grande, Rio Grande, RS, 96201-900, Brazil. FAU - Arias, Jean Lucas de Oliveira AU - Arias JLO AD - Post-graduate Program in Technological and Environmental Chemistry, Escola de Quimica e Alimentos, Laboratorio de Analise de Compostos Organicos e Metais (LACOM), Universidade Federal do Rio Grande, Rio Grande, RS, 96201-900, Brazil. FAU - da Hora, Vanusa Pousada AU - da Hora VP AD - Post-graduate Program in Health Sciences, Faculdade de Medicina, Nucleo Interdisciplinar de Virologia e Imunologia (NIVI), Universidade Federal do Rio Grande, Rio Grande, RS, 96203-900, Brazil. FAU - Merib, Josias AU - Merib J AD - Post-graduate Program in Biosciences, Departamento de Farmacociencias, Grupo de Pesquisa em Preparo de Amostras e Cromatografia (GEPAC), Universidade Federal de Ciencias da Saude de Porto Alegre, Porto Alegre, RS, 90050-170, Brazil. FAU - Primel, Ednei Gilberto AU - Primel EG AD - Post-graduate Program in Technological and Environmental Chemistry, Escola de Quimica e Alimentos, Laboratorio de Analise de Compostos Organicos e Metais (LACOM), Universidade Federal do Rio Grande, Rio Grande, RS, 96201-900, Brazil. Electronic address: eprimelfurg@gmail.com. LA - eng PT - Journal Article PT - Validation Study DEP - 20260623 PL - Netherlands TA - Talanta JT - Talanta JID - 2984816R RN - 0 (Pesticides) RN - 0 (Parabens) RN - 0 (Environmental Pollutants) SB - IM MH - *Colostrum/chemistry MH - Humans MH - Gas Chromatography-Mass Spectrometry/methods MH - Female MH - Tandem Mass Spectrometry/methods MH - Solid Phase Microextraction/methods MH - Pesticides/analysis MH - Parabens/analysis MH - Limit of Detection MH - *Environmental Pollutants/analysis MH - Infant, Newborn OTO - NOTNLM OT - Biological sample OT - Emerging contaminants OT - Gas chromatography OT - Human milk OT - Solid-Phase Microextraction COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/25 00:34 MHDA- 2026/09/09 11:38 CRDT- 2026/06/24 18:08 PHST- 2026/05/14 00:00 [received] PHST- 2026/06/16 00:00 [revised] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/09/09 11:38 [medline] PHST- 2026/06/25 00:34 [pubmed] PHST- 2026/06/24 18:08 [entrez] AID - S0039-9140(26)00859-3 [pii] AID - 10.1016/j.talanta.2026.130203 [doi] PST - ppublish SO - Talanta. 2027 Jan 1;311:130203. doi: 10.1016/j.talanta.2026.130203. Epub 2026 Jun 23. PMID- 42340620 OWN - NLM STAT- MEDLINE DCOM- 20260930 LR - 20261003 IS - 1720-8386 (Electronic) IS - 0391-4097 (Print) IS - 0391-4097 (Linking) VI - 49 IP - 10 DP - 2026 Oct TI - Determinants of pubertal progression and final height in premature pubarche. PG - 2795-2802 LID - 10.1007/s40618-026-02957-6 [doi] AB - BACKGROUND: Premature pubarche (PP), defined as the early onset of pubic hair and often associated with mild androgen excess, is a common reason for referral to a pediatric endocrinologist. A small proportion of cases may progress to central precocious puberty (CPP). Data on the factors determining pubertal tempo and associated growth outcomes in these individuals are limited. OBJECTIVE: To identify predictors of pubertal progression and final height (FH) in girls with PP and to evaluate growth outcomes in those progressing to CPP. DESIGN-METHODS: We retrospectively analyzed 88 girls with PP who attained FH; 13 progressed to CPP (PP-to-CPP). Auxological data, bone age (BA), pubertal development, and plasma androgen profiles were evaluated. RESULTS: At presentation, corrected height SDS (CH-SDS) in girls with PP correlated with BA-SDS and BA/chronological age (BA/CA) ratio (p=0.03 and p=0.007). Corrected FH-SDS was positively associated with baseline CH-SDS in both PP and PP-to-CPP groups (p<0.001 and p=0.0002). Compared with PP, the PP-to-CPP group had higher baseline CH-SDS, BA-SDS and BA/CA ratio (all p=0.02). Baseline CH-SDS was the strongest independent predictor of corrected FH-SDS (p<0.001), while BMI-SDS showed a negative association (p=0.003). Baseline dehydroepiandrosterone-sulfate (DHEA-S) was not associated with CH-SDS, BA advancement, progression to CPP, or corrected FH-SDS in either group. Receiver operating characteristic (ROC) analyses for progression to CPP identified a BA/CA cutoff of 1.2; and a CH-SDS cutoff of 1.8 (p=0.01). CONCLUSION: Growth relative to genetic potential and skeletal maturation at presentation were the strongest predictors of progression to CPP and FH outcomes in girls with PP. Although DHEA-S reflects adrenal maturation and early androgen exposure, baseline DHEA-S concentrations were not associated with progression to CPP or long-term growth outcomes in our cohort. CI - (c) 2026. The Author(s). FAU - Helvacioglu, Didem AU - Helvacioglu D AD - Department of Pediatric Endocrinology, Marmara University, School of Medicine, Istanbul, 34854, Turkey. FAU - Canbaz, Aylin Tugba AU - Canbaz AT AD - Department of Pediatric Endocrinology, Marmara University, School of Medicine, Istanbul, 34854, Turkey. FAU - Eltan, Mehmet AU - Eltan M AD - Department of Pediatric Endocrinology, Marmara University, School of Medicine, Istanbul, 34854, Turkey. FAU - Cosar, Feride AU - Cosar F AD - Department of Pediatric Endocrinology, Marmara University, School of Medicine, Istanbul, 34854, Turkey. FAU - Turan, Serap AU - Turan S AD - Department of Pediatric Endocrinology, Marmara University, School of Medicine, Istanbul, 34854, Turkey. FAU - Bereket, Abdullah AU - Bereket A AD - Department of Pediatric Endocrinology, Marmara University, School of Medicine, Istanbul, 34854, Turkey. FAU - Guran, Tulay AU - Guran T AUID- ORCID: 0000-0003-2658-6866 AD - Department of Pediatric Endocrinology, Marmara University, School of Medicine, Istanbul, 34854, Turkey. tulayguran@yahoo.com. LA - eng PT - Journal Article DEP - 20260624 PL - Italy TA - J Endocrinol Invest JT - Journal of endocrinological investigation JID - 7806594 SB - IM MH - Humans MH - Female MH - *Puberty, Precocious/physiopathology/blood/diagnosis MH - Retrospective Studies MH - Child MH - *Body Height/physiology MH - *Puberty/physiology MH - Follow-Up Studies MH - Disease Progression MH - Prognosis PMC - PMC13627192 OTO - NOTNLM OT - Bone age OT - DHEA-S OT - Final height OT - Precocious puberty OT - Premature adrenarche OT - Premature pubarche COIS- Declarations. Disclosure: The authors have nothing to disclose. EDAT- 2026/06/24 12:35 MHDA- 2026/09/30 17:32 PMCR- 2026/06/24 CRDT- 2026/06/24 11:20 PHST- 2026/04/25 00:00 [received] PHST- 2026/06/14 00:00 [accepted] PHST- 2026/09/30 17:32 [medline] PHST- 2026/06/24 12:35 [pubmed] PHST- 2026/06/24 11:20 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.1007/s40618-026-02957-6 [pii] AID - 2957 [pii] AID - 10.1007/s40618-026-02957-6 [doi] PST - ppublish SO - J Endocrinol Invest. 2026 Oct;49(10):2795-2802. doi: 10.1007/s40618-026-02957-6. Epub 2026 Jun 24. PMID- 42340201 OWN - NLM STAT- MEDLINE DCOM- 20260720 LR - 20260818 IS - 1728-0591 (Electronic) IS - 1728-0583 (Linking) VI - 37 IP - 2 DP - 2026 Aug TI - The associations between screen time and mental health in children aged 0-12: A systematic review. PG - 201-231 LID - 10.2989/17280583.2026.2661687 [doi] AB - BACKGROUND: : It is advised that children up to two years of age avoid any screen time (i.e., using digital screens), that those between the ages of two and five years should not exceed one hour per day, and that children aged five to 12 years should only have access to two hours of screen time per day. However, in the digital age, parents find it difficult to control the time their children spend on screens. AIM: : This article aimed to systematically synthesise the evidence on the associations between screen time and mental health outcomes in children aged 0 to 12 years. METHOD: : A systematic literature review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The search was defined according to the Population, Exposure, Comparator, and Outcomes (PECO) strategy, using the descriptors 'children', 'screen time' and 'mental health' when searching the databases PubMed, Scopus, and PsycINFO. Articles were included if they directly evaluated the associations between screen time and mental health, measured the results using validated instruments, included children aged 0 to 12 years, and were published since 2013. The Newcastle-Ottawa scale was used to check the methodological quality of the studies. The results were described by presenting the characteristics of the studies, the quality assessment, and the associations between screen time and mental health in longitudinal and cross-sectional studies. RESULTS: : This review assessed the quality of evidence and the frequency with which different mental health problems have been investigated in relation to screen time in children. Fifty-two studies were included, with most addressing attention deficit-hyperactivity disorder (n = 19), conduct problems (n = 13), externalising symptoms (n = 9), depression (n = 11), and anxiety (n = 9). Symptoms of attention deficit-hyperactivity disorder, oppositional defiant disorder, mood symptoms, emotional and social difficulties, conduct problems, low self-esteem, and sleep disturbances were positively associated with screen time, presenting evidence considered to be of high quality. LIMITATIONS: : Although this review concluded that screen time significantly affects children's mental health, some limitations should be noted. The lack of longitudinal data made it difficult to establish a clear causal relationship in most studies, and screen time measures may have introduced a potentia memory bias, as well as relying on parental recall. CONCLUSION: : Screen time warrants careful consideration in relation to children's mental health. Promoting off-screen activities may be crucial to reducing the risk of unfavourable mental health outcomes associated with exposure to the digital environment. Future research should focus on longitudinal studies to understand the causal relationships between children's psychosocial responses to the different purposes of screen use and the type of content to which they are exposed. FAU - Santos, Renata Maria Silva AU - Santos RMS AUID- ORCID: 0000-0001-5737-7712 AD - Federal University of Minas Gerais, Graduate Program Molecular Medicine, Belo Horizonte, Minas Gerais, Brazil. FAU - Ventura, Samara de Alcantara AU - Ventura SA AUID- ORCID: 0000-0003-4167-8961 AD - Federal University of Minas Gerais, Scientific Research Program Molecular Medicine, Belo Horizonte, Minas Gerais, Brazil. FAU - Goncalves, Maria Eduarda Oliveira de Albuquerque AU - Goncalves MEOA AUID- ORCID: 0009-0007-0839-9529 AD - Federal University of Minas Gerais, Scientific Research Program Molecular Medicine, Belo Horizonte, Minas Gerais, Brazil. FAU - Nogueira, Yago Jean de Almeida AU - Nogueira YJA AUID- ORCID: 0000-0001-6215-4310 AD - Federal University of Minas Gerais, Scientific Research Program Molecular Medicine, Belo Horizonte, Minas Gerais, Brazil. FAU - Mendes, Camila Guimaraes AU - Mendes CG AUID- ORCID: 0000-0001-8176-814X AD - Federal University of Minas Gerais, Graduate Program Children and Adolescent Health, Belo Horizonte, Minas Gerais, Brazil. FAU - Miranda, Debora Marques AU - Miranda DM AUID- ORCID: 0000-0002-7081-8401 AD - Federal University of Minas Gerais, Department of Pediatrics, Belo Horizonte, Minas Gerais, Brazil. FAU - Romano-Silva, Marco Aurelio AU - Romano-Silva MA AUID- ORCID: 0000-0002-6558-4639 AD - Federal University of Minas Gerais, Department of Psychiatry, Belo Horizonte, Minas Gerais, Brazil. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260624 PL - South Africa TA - J Child Adolesc Ment Health JT - Journal of child and adolescent mental health JID - 101242019 SB - IM MH - Child MH - Child, Preschool MH - Humans MH - Infant MH - Digital Media MH - Media Exposure MH - *Mental Health MH - *Screen Time MH - Male MH - Female MH - Infant, Newborn OTO - NOTNLM OT - children OT - media OT - mental health OT - screen time EDAT- 2026/06/24 12:36 MHDA- 2026/07/20 12:40 CRDT- 2026/06/24 09:53 PHST- 2026/07/20 12:40 [medline] PHST- 2026/06/24 12:36 [pubmed] PHST- 2026/06/24 09:53 [entrez] AID - 10.2989/17280583.2026.2661687 [doi] PST - ppublish SO - J Child Adolesc Ment Health. 2026 Aug;37(2):201-231. doi: 10.2989/17280583.2026.2661687. Epub 2026 Jun 24. PMID- 42340009 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260908 IS - 1365-2788 (Electronic) IS - 0964-2633 (Print) IS - 0964-2633 (Linking) VI - 70 IP - 10 DP - 2026 Oct TI - Validation of the Q87.11 ICD Code for Prader-Willi Syndrome. PG - 1125-1129 LID - 10.1111/jir.70140 [doi] AB - BACKGROUND: Prader-Willi syndrome (PWS) is a rare genetic disorder that is identified by the ICD-10 code Q87.11. Although this code has been used in several large studies, its diagnostic validity has not been evaluated. This study assessed the accuracy of the Q87.11 code for identifying individuals with PWS. METHODS: The electronic health record (EHR) of a large health system was reviewed for patients with the Q87.11 code. Additionally, a 10% random sample of patients with free-text evidence of possible PWS but no code was reviewed. All charts were assessed for PWS using expert review. Diagnostic validity of the Q87.11 code was assessed at both the individual level (i.e., using a single diagnostic code at any point in the EHR to define the patient as having PWS) and encounter level (looking at coding behaviour for individual inpatient or outpatient episodes of care) using sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). RESULTS: Of 2 718 218 patients with >/= 4 recorded encounters, 126 had at least one Q87.11 code; 122 were confirmed to have PWS by chart review. This yielded a PPV of 96.8% (95% CI: 92.0%-99.1%). Full-chart review of patients with text evidence of PWS but no code estimated a code sensitivity of 92.4% (95% CI: 68.9%-100%) and specificity and NPV of 100%. On a per-encounter basis, sensitivity was 79.4% (95% CI: 62.6%-91.1%) for inpatient and 46.0% (95% CI: 44.1%-47.9%) for outpatient visits. CONCLUSIONS: A single use of the Q87.11 diagnostic code produces excellent sensitivity, specificity, PPV and NPV for identifying patients with PWS, although sensitivity is lower for individual outpatient encounters compared with inpatient ones. The overall accuracy of the Q87.11 code supports the validity of using this code in the analysis of administrative claims datasets. CI - (c) 2026 MENCAP and John Wiley & Sons Ltd. FAU - Luccarelli, James AU - Luccarelli J AUID- ORCID: 0000-0002-1606-3917 AD - Massachusetts General Hospital, Boston, Massachusetts, USA. AD - Harvard Medical School, Boston, Massachusetts, USA. FAU - Strong, Theresa V AU - Strong TV AUID- ORCID: 0000-0001-6783-8703 AD - Foundation for Prader-Willi Research, Covina, California, USA. FAU - McCoy, Thomas H Jr AU - McCoy TH Jr AD - Massachusetts General Hospital, Boston, Massachusetts, USA. AD - Harvard Medical School, Boston, Massachusetts, USA. LA - eng GR - T32 MH112485/MH/NIMH NIH HHS/United States GR - Foundation for Prader-Willi Research/ GR - T32MH112485/MH/NIMH NIH HHS/United States GR - T32MH112485/MH/NIMH NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20260624 PL - England TA - J Intellect Disabil Res JT - Journal of intellectual disability research : JIDR JID - 9206090 SB - IM MH - Humans MH - *Prader-Willi Syndrome/diagnosis MH - *International Classification of Diseases/standards MH - Female MH - Child MH - Child, Preschool MH - Adolescent MH - Male MH - Adult MH - *Electronic Health Records/statistics & numerical data/standards MH - Young Adult MH - Sensitivity and Specificity MH - Infant MH - Middle Aged PMC - PMC13374534 MID - NIHMS2192231 OTO - NOTNLM OT - Prader-Willi syndrome OT - coding OT - cohort studies OT - detection COIS- J.L. receives funding from Harvard Medical School Dupont Warren Fellowship and Livingston Awards, the Rappaport Foundation, the American Academy of Child and Adolescent Psychiatry and the Foundation for Prader-Willi Research. He has received equity and consulting fees from Revival Therapeutics Inc. and consulting fees from Soleno Therapeutics. T.V.S. is an employee of the Foundation for Prader-Willi Research and has received consulting fees from Soleno Therapeutics. T.H.M. receives funding, through his institution, from National Institute of Health, Telefonica Alfa, InterSystems, Philips Research North America and honoraria from Springer Nature publishing. EDAT- 2026/06/24 12:36 MHDA- 2026/09/08 23:35 PMCR- 2026/09/09 CRDT- 2026/06/24 09:39 PHST- 2026/06/15 00:00 [revised] PHST- 2025/08/20 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/09/08 23:35 [medline] PHST- 2026/06/24 12:36 [pubmed] PHST- 2026/06/24 09:39 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - JIR70140 [pii] AID - 10.1111/jir.70140 [doi] PST - ppublish SO - J Intellect Disabil Res. 2026 Oct;70(10):1125-1129. doi: 10.1111/jir.70140. Epub 2026 Jun 24. PMID- 42339687 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260624 IS - 1471-2865 (Electronic) IS - 1358-2267 (Linking) VI - 31 IP - 3 DP - 2026 Jul TI - Aerobic Exercise Combined With Repetitive Transcranial Magnetic Stimulation in College Students at Suicide Risk: Protocol for a Single-Centre Non-Randomised Controlled Pilot Study. PG - e70263 LID - 10.1002/pri.70263 [doi] AB - BACKGROUND: College students are vulnerable to depressive symptoms, suicidal ideation, sleep disturbance, and stress-related psychological problems. Aerobic exercise and repetitive transcranial magnetic stimulation (rTMS) have each shown therapeutic potential in affective disorders, but evidence on their combined application in college students at suicide risk remains limited, particularly when neurophysiological outcomes are considered. OBJECTIVES: To evaluate the feasibility, safety, and preliminary effects of aerobic exercise combined with rTMS on suicidal ideation, depressive symptoms, sleep, and prefrontal functional activation in college students at suicide risk. METHODS: This prospective single-centre non-randomised controlled pilot study will enrol students aged 18-21 years who are identified as being at suicide risk by the Xinhai University Crisis Intervention System. At-risk participants will enter one of three groups: active rTMS plus aerobic exercise, sham rTMS plus aerobic exercise, or standardised group psychological intervention/usual support. A separately recruited healthy reference cohort will complete the same assessment schedule without active treatment. Active rTMS will be delivered over the left dorsolateral prefrontal cortex at 10 Hz and 120% of the individual motor threshold once daily for 2 weeks. Aerobic exercise will be prescribed at a target heart-rate zone of 135-164 beats/min for 30-60 min per session every 2 days for 2 weeks, with heart rate and adherence objectively monitored. OUTCOME MEASURES: The primary outcomes are changes in the Self-rating Idea of Suicide Scale (SIOSS) total score and Self-rating Depression Scale (SDS) standard score from baseline to week 4. Secondary outcomes include SIOSS and SDS dimensions, total sleep time, task-related and resting-state functional near-infrared spectroscopy (fNIRS) measures, adherence, concomitant care, and adverse events. ETHICS AND DISSEMINATION: The study was approved by the Ethical Review Committee of Yancheng First People's Hospital (Approval No. 2023-K-230) and the Ethics Committee of INTI International University (Approval No. INTI-IU/FHLS-RC/BTCMI/AUGUST2022/003). Findings will be disseminated through peer-reviewed publications and academic conferences. TRIAL REGISTRATION: Chinese Clinical Trial Registry, ChiCTR2400079723. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Yu, Cui AU - Yu C AUID- ORCID: 0009-0005-7604-3992 AD - Jiangsu Medical College, Yancheng, China. FAU - Lu, Yuwen AU - Lu Y AD - Jiangsu Vocational Institute of Commerce, Nanjing, China. FAU - Peng, Cheng AU - Peng C AD - Jiangsu Medical College, Yancheng, China. FAU - Wang, Ziyi AU - Wang Z AD - Jiangsu Medical College, Yancheng, China. FAU - Wong, Ling Shing AU - Wong LS AUID- ORCID: 0000-0002-5869-0804 AD - INTI International University, Nilai, Malaysia. FAU - Dong, Xinchun AU - Dong X AUID- ORCID: 0009-0002-9717-6151 AD - Jiangsu Medical College, Yancheng, China. LA - eng GR - 2022B02/Jiangsu Primary Health Development and General Medicine Education Research Center/ GR - JSS-L-2024024/2024 Jiangsu Provincial Social Education Planning Project/ GR - C/2024/01/98/2024 Jiangsu Provincial Education Science Planning Project Youth Special/ GR - Z202512/The Major Research Project of the Wuxi Municipal Health Commission/ GR - Q202419/Youth Project of the Wuxi Municipal Health Commission/ PT - Journal Article PL - United States TA - Physiother Res Int JT - Physiotherapy research international : the journal for researchers and clinicians in physical therapy JID - 9612022 SB - IM MH - Humans MH - Pilot Projects MH - Young Adult MH - *Transcranial Magnetic Stimulation/methods MH - Female MH - Adolescent MH - Prospective Studies MH - Male MH - *Exercise/psychology MH - *Students/psychology MH - *Suicide Prevention MH - Depression/therapy MH - Suicidal Ideation MH - Feasibility Studies MH - Universities OTO - NOTNLM OT - aerobic exercise OT - college students OT - depression OT - feasibility studies OT - functional near-infrared spectroscopy OT - repetitive transcranial magnetic stimulation OT - sleep OT - suicidal ideation OT - suicide risk EDAT- 2026/06/24 12:35 MHDA- 2026/06/25 00:34 CRDT- 2026/06/24 06:33 PHST- 2026/05/26 00:00 [revised] PHST- 2026/04/19 00:00 [received] PHST- 2026/06/05 00:00 [accepted] PHST- 2026/06/25 00:34 [medline] PHST- 2026/06/24 12:35 [pubmed] PHST- 2026/06/24 06:33 [entrez] AID - 10.1002/pri.70263 [doi] PST - ppublish SO - Physiother Res Int. 2026 Jul;31(3):e70263. doi: 10.1002/pri.70263. PMID- 42339555 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260911 IS - 1365-2788 (Electronic) IS - 0964-2633 (Print) IS - 0964-2633 (Linking) VI - 70 IP - 10 DP - 2026 Oct TI - Assessing the Diagnostic Performance of Triglyceride-Glucose-Based Indices for Early Detection of Metabolic Syndrome in Paediatric Down Syndrome. PG - 1022-1032 LID - 10.1111/jir.70134 [doi] AB - BACKGROUND: Down syndrome (DS) youth have an increased risk of metabolic syndrome (MetS). This study assessed the diagnostic performance of the triglyceride-glucose index (TyG) and its derivatives-TyG-BMI, TyG-waist circumference (WC) and TyG-waist-to-height ratio (WHtR) in detecting MetS compared with traditional markers. METHODS: We retrospectively analysed data from 60 DS patients and 40 controls; IR was estimated using HOMA-IR, TyG, TyG-BMI, TyG-WC and TyG-WHtR indices. MetS was defined by the presence of at least three of the following criteria: BMI z-score >/= 2 SD and/or WC/H ratio >/= 0.5; fasting glucose > 100 mg/dL and/or pathological HOMA-IR; dyslipidaemia; hypertension. RESULTS: MetS prevalence was 15% in DS. HOMA-IR showed the highest sensitivity (0.667) and specificity (0.80) to detect MetS, while TyG demonstrated similar performance (sensitivity 0.667; specificity 0.843) and the best overall accuracy (0.817). Composite indices showed moderate accuracy but high specificity. CONCLUSIONS: TyG, being simple and cost-effective, may be a valuable alternative for early MetS detection in DS. CI - (c) 2026 The Author(s). Journal of Intellectual Disability Research published by MENCAP and John Wiley & Sons Ltd. FAU - Calcaterra, Valeria AU - Calcaterra V AUID- ORCID: 0000-0002-2137-5974 AD - Pediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, Pavia, Italy. AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. FAU - Labati, Lucia AU - Labati L AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. AD - Department of Biomedical and Clinical Science "L. Sacco", University of Milan, Milan, Italy. FAU - Gazzarri, Alessandra Anna AU - Gazzarri AA AD - Associazione Vivi Down Onlus, Milan, Italy. FAU - De Lorenzo, Alice AU - De Lorenzo A AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. FAU - Scavone, Ilaria Anna Maria AU - Scavone IAM AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. FAU - Zuccotti, Gianvincenzo AU - Zuccotti G AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. AD - Department of Biomedical and Clinical Science "L. Sacco", University of Milan, Milan, Italy. LA - eng PT - Journal Article DEP - 20260624 PL - England TA - J Intellect Disabil Res JT - Journal of intellectual disability research : JIDR JID - 9206090 RN - 0 (Triglycerides) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - *Metabolic Syndrome/diagnosis/epidemiology/blood MH - *Triglycerides/blood MH - Female MH - Retrospective Studies MH - Child MH - Early Diagnosis MH - *Down Syndrome/epidemiology/blood MH - Male MH - *Blood Glucose/metabolism MH - Adolescent MH - Sensitivity and Specificity MH - Child, Preschool PMC - PMC13553318 OTO - NOTNLM OT - Down syndrome OT - HOMA-IR OT - children OT - metabolic syndrome OT - paediatrics OT - triglyceride-glucose-based indices COIS- The authors declare no conflicts of interest. EDAT- 2026/06/24 06:39 MHDA- 2026/09/08 23:35 PMCR- 2026/09/09 CRDT- 2026/06/24 05:03 PHST- 2026/05/29 00:00 [revised] PHST- 2025/10/24 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/09/08 23:35 [medline] PHST- 2026/06/24 06:39 [pubmed] PHST- 2026/06/24 05:03 [entrez] PHST- 2026/09/09 00:00 [pmc-release] AID - JIR70134 [pii] AID - 10.1111/jir.70134 [doi] PST - ppublish SO - J Intellect Disabil Res. 2026 Oct;70(10):1022-1032. doi: 10.1111/jir.70134. Epub 2026 Jun 24. PMID- 42339358 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260624 LR - 20260913 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Health-related perceptions and drinking motives as actionable targets for precision prevention of high sugar-sweetened beverage intake among Chinese adolescents. PG - 1803900 LID - 10.3389/fnut.2026.1803900 [doi] LID - 1803900 AB - OBJECTIVE: To quantify the contribution of modifiable individual risk factors (MIRFs)-particularly health-related perceptions and drinking motives-to high sugar-sweetened beverage (SSB) intake among adolescents, and to evaluate their relevance as actionable targets for precision-oriented prevention. METHODS: A school-based survey was conducted among 1,466 Chinese junior high school students to assess SSB consumption and related individual-level factors. Multivariable logistic regression was used to identify factors associated with high SSB intake. To illustrate the practical value of these modifiable factors for identifying and targeting high-risk individuals, a population-based risk stratification approach was applied and evaluated using internal and external datasets. Model performance was assessed using the area under the receiver operating characteristic curve (AUC-ROC), calibration curves, and decision curve analysis (DCA). RESULTS: Four MIRFs-drinking SSBs as water (OR = 13.00, 95% CI: 7.33-23.07, R (2) = 11.12%), belief in no health effects ["Yes": OR = 10.61(4.82-23.34); "Unsure": OR = 2.37 (1.21-4.62); R (2) = 4.99%], a strong desire to consume SSBs (OR = 2.45, 1.49-4.02, R (2) = 1.91%), and drinking due to boredom (OR = 2.27, 1.25-4.13, R (2) = 1.00%)-were strongly associated with high SSB intake (p < 0.05), collectively accounting for 71.1% of the model-explained variance. The full model demonstrated good discrimination, with AUCs of 0.858 in the training set, 0.736 in the internal validation set, and 0.751 in the external validation set, along with satisfactory calibration. A simplified model including only these MIRFs showed comparable net benefit in DCA, supporting their potential utility for efficient screening and risk stratification. CONCLUSION: Health-related perceptions and non-physiological drinking motives are key modifiable correlates of high SSB intake among adolescents. An MIRF-based screening and targeting approach may support precision prevention strategies and more efficient allocation of intervention resources in school- and community-based public health programs. CI - Copyright (c) 2026 Peng, Yi, Yan, Chen, Zhou, Bai, Sheng, Fang, Wang, Lin and Wu. FAU - Peng, Yuting AU - Peng Y AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. AD - Department of Health Management, Changzhou Health Vocational Technology College, Changzhou, China. FAU - Yi, Junyao AU - Yi J AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States. FAU - Yan, Xiaoyun AU - Yan X AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Chen, Xinyi AU - Chen X AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Zhou, Yu AU - Zhou Y AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Bai, Zijun AU - Bai Z AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Sheng, Zuyun AU - Sheng Z AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Fang, Dawei AU - Fang D AD - Jiangsu Defuxiyun Health Technology Co., Ltd, Nanjing, China. FAU - Wang, Danyang AU - Wang D AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Lin, Xiaofang AU - Lin X AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Wu, Jieshu AU - Wu J AD - Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China. LA - eng PT - Journal Article DEP - 20260608 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13283865 OTO - NOTNLM OT - adolescent OT - drinking motives OT - health-related perceptions OT - modifiable individual risk factors OT - nutritional epidemiology OT - precision prevention OT - sugar-sweetened beverage COIS- DF was employed by Jiangsu Defuxiyun Health Technology Co., Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/24 06:38 MHDA- 2026/06/24 06:39 PMCR- 2026/06/08 CRDT- 2026/06/24 04:46 PHST- 2026/02/04 00:00 [received] PHST- 2026/04/07 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/06/24 06:39 [medline] PHST- 2026/06/24 06:38 [pubmed] PHST- 2026/06/24 04:46 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - 10.3389/fnut.2026.1803900 [doi] PST - epublish SO - Front Nutr. 2026 Jun 8;13:1803900. doi: 10.3389/fnut.2026.1803900. eCollection 2026. PMID- 42339296 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260922 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Comparison of Chinese and international birth weight standards in predicting early childhood growth outcomes: a retrospective cohort study. PG - 1810686 LID - 10.3389/fped.2026.1810686 [doi] LID - 1810686 AB - BACKGROUND: Birth weight serves as a key predictor for long-term health trajectories. Currently, both international and Chinese standards are used to evaluate birth weight. This study aims to compare the Chinese Newborn Growth Standards (CNGS) and the INTERGROWTH-21st (IG-21) standards in terms of birth weight classification and their predictive performance for the wasting and possible risk of overweight during infancy and toddlerhood. METHODS: This retrospective cohort study included 1,149 full-term singleton infants with longitudinal growth data recorded at 1, 2, and 3 years of age. Birth weight was categorized according to both the CNGS and IG-21 standards. Wasting and possible risk of overweight during infancy and toddlerhood were assessed according to World Health Organization (WHO) standards. Agreement between the two classification systems was evaluated using the weighted Kappa statistic. The predictive performance of each standard for growth outcomes was compared using modified Poisson regression models. RESULTS: The CNGS and IG-21 standards showed high agreement (Kappa = 0.856). In terms of predictive performance, based on the CNGS, small for gestational age (SGA) was significantly associated with wasting at 1 and 2 years, and large for gestational age (LGA) was significantly associated with possible risk of overweight at 2 years. In contrast, based on the IG-21 standards, only SGA showed a significant association with wasting across all follow-up ages. Overall, the CNGS demonstrated higher specificity in predicting wasting and possible risk of overweight in infants and toddlers. CONCLUSION: Although the CNGS and IG-21 standards showed high agreement, the CNGS demonstrated superior predictive validity for growth outcomes during infancy and toddlerhood, particularly for possible risk of overweight. CI - (c) 2026 Zhang, Zhang, Gao, Li, Zhang, Liu and Li. FAU - Zhang, Ting AU - Zhang T AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Zhang, Zhenyu AU - Zhang Z AD - School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China. FAU - Gao, Mai AU - Gao M AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Li, Ziyun AU - Li Z AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Zhang, Li AU - Zhang L AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Liu, Huijuan AU - Liu H AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. FAU - Li, Yan AU - Li Y AD - Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, Shandong, China. LA - eng PT - Journal Article DEP - 20260608 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 EIN - Front Pediatr. 2026 Jul 20;14:1905752. doi: 10.3389/fped.2026.1905752. PMID: 42549124 PMC - PMC13284055 OTO - NOTNLM OT - birth weight OT - growth standards OT - possible risk of overweight OT - predictive validity OT - wasting COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/24 06:36 MHDA- 2026/06/24 06:37 PMCR- 2026/06/08 CRDT- 2026/06/24 04:45 PHST- 2026/02/13 00:00 [received] PHST- 2026/05/14 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/24 06:36 [pubmed] PHST- 2026/06/24 06:37 [medline] PHST- 2026/06/24 04:45 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - 10.3389/fped.2026.1810686 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 8;14:1810686. doi: 10.3389/fped.2026.1810686. eCollection 2026. PMID- 42339295 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260624 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - A novel nutritional tool to identify infants at risk of stunting. PG - 1782208 LID - 10.3389/fped.2026.1782208 [doi] LID - 1782208 AB - OBJECTIVE: This study aimed to develop and validate a novel scoring system and prediction algorithm integrating growth, nutritional, and biochemical indicators for the identification of infant stunting, defined as length-for-age Z-score < -2 standard deviations according to the World Health Organization (WHO) Child Growth Standards. METHODS: A retrospective cohort of 380 infants (aged 0-12 months) undergoing routine health examinations was enrolled. Participants were randomly allocated to a training set (n = 266) and a internal validation set (n = 114) in a 7:3 ratio. In the training set, univariate analysis identified candidate indicators (P < 0.05). Multivariate logistic regression and Least Absolute Shrinkage and Selection Operator (LASSO) regression were subsequently used to select independent predictors and prevent overfitting. Three machine learning models-Random Forest, Gradient Boosting, and Support Vector Machine-were constructed. Model performance was evaluated using the Area Under the Receiver Operating Characteristic Curve (AUC), calibration curves, and Decision Curve Analysis. Interpretability was assessed via SHapley Additive exPlanations (SHAP) values. A visual nomogram was developed. RESULTS: Baseline characteristics were comparable between the training and internal validation sets (P > 0.05). Five indicators were significantly associated with stunting, including infant weight Z-score, length Z-score, length growth velocity, diversity of complementary foods, and hemoglobin (Hb). Length growth velocity was the strongest predictor (OR=0.340, 95% CI: 0.211-0.548, P < 0.001). LASSO regression confirmed infant weight Z-score, length Z-score, length growth velocity, number of complementary food types, and Hb as the optimal variable combination. The Gradient Boosting model demonstrated superior performance, with an AUC of 0.861 (95% CI: 0.784-0.938) in the training set and 0.850 (95% CI: 0.699-1.000) in the internal validation set. Its calibration was excellent, and decision curve analysis indicated a higher net benefit across a wide risk threshold range. SHAP analysis identified infant weight Z-score as the most critical predictive variable. The nomogram provided a practical tool for quantitative risk assessment. CONCLUSION: The developed nutritional scoring system and Gradient Boosting prediction algorithm exhibited robust performance in identifying infants at risk of stunting. This tool facilitates early quantitative risk assessment and supports targeted clinical interventions. CI - (c) 2026 Wei, Su, Wei and Zhan. FAU - Wei, Qian AU - Wei Q AD - Department of Pediatrics, Affiliated Hospital of Hebei University, Baoding, Hebei Province, China. FAU - Su, Dandan AU - Su D AD - Department of Pediatrics, Affiliated Hospital of Hebei University, Baoding, Hebei Province, China. FAU - Wei, Jihong AU - Wei J AD - Department of Pediatrics, Affiliated Hospital of Hebei University, Baoding, Hebei Province, China. FAU - Zhan, Yaowu AU - Zhan Y AD - Department of Pediatrics, Affiliated Hospital of Hebei University, Baoding, Hebei Province, China. LA - eng PT - Journal Article DEP - 20260608 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13283820 OTO - NOTNLM OT - SHAP values OT - infant growth faltering OT - machine learning OT - nutritional scoring system OT - prediction algorithm COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/24 06:38 MHDA- 2026/06/24 06:39 PMCR- 2026/06/08 CRDT- 2026/06/24 04:45 PHST- 2026/01/06 00:00 [received] PHST- 2026/05/21 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/24 06:39 [medline] PHST- 2026/06/24 06:38 [pubmed] PHST- 2026/06/24 04:45 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - 10.3389/fped.2026.1782208 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 8;14:1782208. doi: 10.3389/fped.2026.1782208. eCollection 2026. PMID- 42339293 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260624 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Baseline gut microbiome features associated with fecal calprotectin response to exclusive enteral nutrition in pediatric Crohn's disease. PG - 1833193 LID - 10.3389/fped.2026.1833193 [doi] LID - 1833193 AB - BACKGROUND AND AIMS: Exclusive enteral nutrition is an established induction therapy for pediatric Crohn's disease, but biochemical response varies across patients. We assessed whether baseline gut microbiome features were associated with fecal calprotectin response and whether treatment-related taxonomic shifts could be interpreted alongside reported fecal biochemical summaries. METHODS: We re-analyzed a public pediatric cohort (PRJEB14084). Paired baseline and end-of-treatment microbiome profiles were summarized as within-subject genus-level changes. Reported stool biochemical summaries were used as contextual data. Baseline model performance was explored by repeated nested cross-validation with calibration assessment. An independent pediatric cohort (PRJEB33603) was used only for summary-level external comparison. RESULTS: Several genera changed consistently during treatment. Stool biochemical summaries showed lower total amino acids and tryptophan and higher secondary bile-acid proportion and hydrophobicity index at the end of treatment. The baseline model showed modest discrimination with broad uncertainty (mean area under the receiver operating characteristic curve, 0.655; 95% confidence interval, 0.450-0.850). In the external comparison, 7 of 12 overlapping genera showed concordant directions. CONCLUSION: In this public cohort, baseline microbiome features showed an exploratory association with fecal calprotectin response, but the estimates were imprecise. External comparison was limited to published summary tables, and all inferences remain association-based. CI - (c) 2026 Zheng and Chen. FAU - Zheng, Hongwei AU - Zheng H AD - School of Medicine, Quanzhou Medical College, Quanzhou, Fujian, China. FAU - Chen, Wenbiao AU - Chen W AD - School of Medicine, Quanzhou Medical College, Quanzhou, Fujian, China. LA - eng PT - Journal Article DEP - 20260608 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13284047 OTO - NOTNLM OT - 16S rRNA gene sequencing OT - exclusive enteral nutrition OT - fecal calprotectin OT - gut microbiome OT - pediatric Crohn's disease COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/24 06:38 MHDA- 2026/06/24 06:39 PMCR- 2026/06/08 CRDT- 2026/06/24 04:45 PHST- 2026/03/18 00:00 [received] PHST- 2026/04/26 00:00 [revised] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/06/24 06:39 [medline] PHST- 2026/06/24 06:38 [pubmed] PHST- 2026/06/24 04:45 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - 10.3389/fped.2026.1833193 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 8;14:1833193. doi: 10.3389/fped.2026.1833193. eCollection 2026. PMID- 42338068 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260813 IS - 2398-9238 (Electronic) IS - 2398-9238 (Linking) VI - 9 IP - 4 DP - 2026 Jul TI - Dietary Phytochemical Index and Its Relationship With Diminished Ovarian Reserve: Evidence From a Case-Control Study. PG - e70201 LID - 10.1002/edm2.70201 [doi] LID - e70201 AB - INTRODUCTION: Diminished ovarian reserve (DOR) represents a significant contributor to female infertility and adverse reproductive outcomes. Although diet may play a role, the specific impact of phytochemical-rich dietary patterns remains underexplored. So, we aimed to investigate the association between adherence to a dietary phytochemical index (DPI) and the likelihood of DOR among women attending fertility clinics. METHODS: This case-control study enrolled 370 women, comprising 120 individuals diagnosed with DOR and 250 age- and body mass index (BMI)-matched controls with normal ovarian reserve. A validated semi-quantitative food frequency questionnaire (FFQ) was applied to assess dietary intakes and, accordingly, DPI was calculated as the proportion of total energy intake obtained from phytochemical-abundant foods. Antral follicle count (AFC) and serum anti-Mullerian hormone (AMH) measurements were utilized as indicators of ovarian reserve. The association between DPI and the odds of DOR was investigated using multivariable logistic regression models. RESULTS: Our findings showed that higher DPI was associated with a reduced odds of DOR (Q4 vs. Q1 OR: 0.79; 95% CI: 0.55-0.93; p-trend = 0.010). After adjustment for physical activity and energy intake, the association remained significant (OR: 0.80; 95% CI: 0.54-0.95; p-trend = 0.033). In the fully adjusted model, which included additional adjustments for fat mass and body mass index, women in the highest DPI quartile had 27% lower odds of DOR compared to those in the lowest quartile (OR: 0.73; 95% CI: 0.42-0.97; p-trend = 0.02). Besides, in the control group, AFC differed significantly across DPI quartiles (p < 0.001), with the highest mean in the second quartile. CONCLUSION: Our findings suggest that a phytochemical-rich diet may help reduce the odds of DOR, highlighting the role of diet in reproductive health. However, further prospective studies and mechanistic research are warranted to confirm these results and clarify underlying pathways. CI - (c) 2026 The Author(s). Endocrinology, Diabetes & Metabolism published by John Wiley & Sons Ltd. FAU - Khodarahmi, Mahdieh AU - Khodarahmi M AUID- ORCID: 0000-0002-0689-6958 AD - Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Askari, Gholamreza AU - Askari G AD - Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Vajdi, Mahdi AU - Vajdi M AD - Department of Community Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Mokari-Yamchi, Amin AU - Mokari-Yamchi A AD - Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran. FAU - Ghasemi-Tehrani, Hatav AU - Ghasemi-Tehrani H AD - Department of Obstetrics and Gynecology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. FAU - Kalatehjari, Maryam AU - Kalatehjari M AD - Obstetrics & Gynecology Department, University of Washington, Seattle, USA. FAU - Ghavami, Abed AU - Ghavami A AD - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. LA - eng GR - 2401257/Isfahan University of Medical Sciences/ PT - Journal Article PT - Observational Study PL - England TA - Endocrinol Diabetes Metab JT - Endocrinology, diabetes & metabolism JID - 101732442 RN - 0 (Phytochemicals) RN - 80497-65-0 (Anti-Mullerian Hormone) SB - IM MH - Case-Control Studies MH - *Diet/adverse effects/statistics & numerical data MH - *Phytochemicals/administration & dosage MH - *Ovarian Reserve/drug effects/physiology MH - *Eating/physiology MH - Humans MH - Female MH - Adult MH - Body Mass Index MH - Infertility, Female/epidemiology/etiology MH - Diet Surveys MH - Anti-Mullerian Hormone/blood MH - Ovarian Follicle/drug effects MH - Adolescent MH - Young Adult MH - Middle Aged PMC - PMC13291195 OTO - NOTNLM OT - dietary phytochemical index OT - diminished ovarian reserve OT - infertility OT - ovarian function OT - phytochemicals COIS- The authors declare no conflicts interest. EDAT- 2026/06/24 06:38 MHDA- 2026/06/25 00:33 PMCR- 2026/06/23 CRDT- 2026/06/24 02:23 PHST- 2026/02/08 00:00 [revised] PHST- 2025/11/04 00:00 [received] PHST- 2026/02/23 00:00 [accepted] PHST- 2026/06/25 00:33 [medline] PHST- 2026/06/24 06:38 [pubmed] PHST- 2026/06/24 02:23 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - EDM270201 [pii] AID - 10.1002/edm2.70201 [doi] PST - ppublish SO - Endocrinol Diabetes Metab. 2026 Jul;9(4):e70201. doi: 10.1002/edm2.70201. PMID- 42337511 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260916 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 24 TI - Nonlinear association between body mass index and physical fitness in primary school children: a single-school cross-sectional study using generalized additive models. LID - 10.1186/s12887-026-07226-2 [doi] LID - 843 AB - BACKGROUND: Body mass index (BMI) is associated with physical fitness in children, but the functional form of this relationship is debated. Using routinely collected fitness-monitoring data from a single primary school, this study examined whether BMI is nonlinearly associated with physical fitness in primary school children, treating the analysis as a methodological, single-school demonstration rather than a population-representative survey. METHODS: We analysed records from 1,572 students (808 boys, 764 girls; Grades 1-6) nested within 37 classes in one school in Tianfu New Area, Sichuan, China. BMI was calculated from measured height and weight. Four fitness indicators available for the whole sample-vital capacity, 50-m sprint, sit-and-reach, and 1-min rope skipping-were analysed as the primary outcomes; a composite index (mean of sex- and grade-standardised z-scores, with the 50-m sprint reverse-coded so that higher scores denote better fitness) was retained as a secondary descriptive summary. Quadratic regression and generalized additive models (GAMs; penalised cubic B-splines) adjusted for sex and grade were used to model BMI. Primary overall and sex-stratified models used cluster-robust standard errors at the class level; grade-stratified exploratory models, each based on only a few classes, were assessed with model-based smooth tests. Nonlinearity was quantified with the effective degrees of freedom (EDF) of the BMI smooth and a Wald test, and exploratory subgroup analyses were corrected for multiple comparisons (Benjamini-Hochberg false discovery rate, FDR). RESULTS: The class-level intraclass correlation was non-negligible for BMI (0.124) and the 50-m sprint (0.085), confirming the need to account for clustering. After cluster-robust adjustment, BMI showed a statistically supported nonlinear association with the 50-m sprint (EDF = 4.4, P < 0.001), 1-min rope skipping (EDF = 5.1, P < 0.001), and the composite index (EDF = 5.7, P < 0.001), but not with vital capacity (EDF = 1.0, P = 0.44). For the 50-m sprint the best predicted performance was well localised at a BMI of about 16.2 kg/m(2); for 1-min rope skipping the optimum was less precisely located, and for the composite index the cluster bootstrap did not identify a stable interior optimum (it spread the maximum across approximately 15.7-21.2 kg/m(2), with a median of approximately 19.7 kg/m(2) well above the full-sample point estimate). Predicted performance declined at both lower and higher BMI. The quadratic turning point (~ 18.5 kg/m(2)) was higher than the GAM peak and moved toward the GAM estimate when sparse BMI tails were trimmed, indicating sensitivity of the parabola to extreme values. In exploratory, FDR-corrected subgroup analyses, nonlinearity remained statistically supported in girls and in Grades 1 and 3 but not in boys or other grades; these subgroup findings are hypothesis-generating only. CONCLUSIONS: In this single-school sample, the BMI-fitness association was nonlinear for speed- and coordination-related tasks; for the 50-m sprint the best predicted performance was well localised at an intermediate BMI (about 16.2 kg/m(2)), whereas for the composite index no stable single optimum could be identified. Because the data come from one school and lack body-composition and physical-activity measures, the estimated optima are sample-specific descriptive features and should not be read as intervention targets. The study illustrates how routine school fitness data and GAMs can describe BMI-fitness patterns beyond categorical comparisons, and motivates multi-school, longitudinal confirmation. CI - (c) 2026. The Author(s). FAU - Zhu, Junhui AU - Zhu J AD - Faculty of Education, Universiti Kebangsaan Malaysia, Bangi, Malaysia. FAU - Zhao, Mingling AU - Zhao M AD - School of Urban Construction, Chengdu Polytechnic, Chengdu, China. FAU - Zheng, Meiling AU - Zheng M AD - Tianfu School of Tsinghua University High School, Meishan, China. FAU - Wang, Ling AU - Wang L AD - Faculty of Education, Universiti Kebangsaan Malaysia, Bangi, Malaysia. FAU - Li, Qiuyue AU - Li Q AD - School of Physical Education and Big Health, Sichuan Technology and Business University, Chengdu, China. 1039571063@qq.com. LA - eng PT - Journal Article DEP - 20260624 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Body Mass Index MH - *Physical Fitness/physiology MH - Male MH - Child MH - Cross-Sectional Studies MH - Female MH - China MH - Schools MH - Nonlinear Dynamics PMC - PMC13555981 OTO - NOTNLM OT - Body mass index OT - Children OT - Cluster-robust inference OT - Generalized additive models OT - Nonlinear association OT - Physical fitness OT - School health COIS- Declarations. Ethics approval and consent to participate: This study involving human participants was reviewed and approved by the Ethics Committee of Yibin University (Approval No. YBULLXS26041601). All procedures were performed in accordance with the Declaration of Helsinki and relevant guidelines and regulations. Written informed consent was obtained from the participants' legal guardians, and assent was obtained from the children where appropriate. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/24 06:37 MHDA- 2026/09/09 11:38 PMCR- 2026/06/24 CRDT- 2026/06/24 00:07 PHST- 2026/04/22 00:00 [received] PHST- 2026/06/22 00:00 [accepted] PHST- 2026/09/09 11:38 [medline] PHST- 2026/06/24 06:37 [pubmed] PHST- 2026/06/24 00:07 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.1186/s12887-026-07226-2 [pii] AID - 7226 [pii] AID - 10.1186/s12887-026-07226-2 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 24;26(1):843. doi: 10.1186/s12887-026-07226-2. PMID- 42337484 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260813 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jun 23 TI - Single-model deep learning approach for simultaneous cervical vertebral maturation staging and skeletal jaw relationship on lateral cephalograms using YOLOv8 and CNN. LID - 10.1186/s12903-026-08578-y [doi] LID - 1107 AB - BACKGROUND: This study aimed to develop an integrated artificial intelligence (AI) pipeline for cervical vertebral maturation (CVM) staging and skeletal jaw relationships and to validate its output against the results of human observers. METHODS: A total of 720 lateral cephalograms were collected from the archives of the orthodontic department. The participants' ages ranged from 8 to 18 years. Cephalograms were categorized into six cervical stages based on McNamara's criteria and classified into skeletal Class I, II, and III patterns based on their ANB angles. The dataset was divided into a training set (n = 540) and a test set (n = 180). The training set was used to train a convolutional neural network (CNN) and a YOLOv8 model. The test set of cephalograms was coded and randomly assigned to two orthodontists for comparison with the AI model results using weighted kappa and Cohen's kappa statistical analyses to verify accuracy. RESULTS: For human observers, the interobserver agreement ranges were as follows: (kappaw approximately 0.976-0.989) for skeletal classification and (kappaw approximately 0.956-0.999) for CVM staging, while the intra-observer reliability was also almost perfect for both methods (kappaw approximately 0.82- 0.85). Substantial agreement was found between the generated AI model and human observers for skeletal classification (kappa = 0.725) and CVM staging (kappa = 0.786). Both results were statistically significant (p < 0.01). CONCLUSIONS: Within the limitations of this study, the AI model exhibited substantial agreement with human observers for CVM staging and skeletal assessment, demonstrating its potential viability as a clinical decision-support tool. CI - (c) 2026. The Author(s). FAU - Alotaibi, Naif Munawir AU - Alotaibi NM AUID- ORCID: 0009-0002-2383-3462 AD - Orthodontic Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt. dr.naifmo@gmail.com. FAU - Kamel, Ahmed Mohamed AU - Kamel AM AUID- ORCID: 0000-0003-1940-5270 AD - Orthodontic Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt. FAU - Khalil, Abeer Twakol AU - Khalil AT AUID- ORCID: 0000-0003-4223-2144 AD - Department of Electronic and Communication Engineering, Faculty of Engineering, Mansoura University, Mansoura, Egypt. FAU - Hammad, Shaza Mohammad AU - Hammad SM AUID- ORCID: 0000-0002-6662-5068 AD - Orthodontic Department, Faculty of Dentistry, Mansoura University, Mansoura, Egypt. LA - eng PT - Journal Article DEP - 20260623 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Cervical Vertebrae/growth & development/diagnostic imaging MH - *Cephalometry/methods MH - Child MH - Adolescent MH - *Deep Learning MH - Convolutional Neural Networks MH - Female MH - *Age Determination by Skeleton/methods MH - Male PMC - PMC13289470 OTO - NOTNLM OT - Artificial intelligence OT - Cervical vertebral maturation OT - Skeletal classification. COIS- Declarations. Ethics approval and consent to participate: This study was approved by the dental research ethics committee of the Faculty of Dentistry at Mansoura University in Egypt (code no. A0703024OR) and conducted in accordance with the Declaration of Helsinki. The need for informed consent was waived by the committee due to the nature of the study and the anonymization of all data. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/24 06:38 MHDA- 2026/06/24 18:35 PMCR- 2026/06/23 CRDT- 2026/06/24 00:06 PHST- 2025/11/12 00:00 [received] PHST- 2026/05/05 00:00 [accepted] PHST- 2026/06/24 18:35 [medline] PHST- 2026/06/24 06:38 [pubmed] PHST- 2026/06/24 00:06 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.1186/s12903-026-08578-y [pii] AID - 8578 [pii] AID - 10.1186/s12903-026-08578-y [doi] PST - epublish SO - BMC Oral Health. 2026 Jun 23;26(1):1107. doi: 10.1186/s12903-026-08578-y. PMID- 42337032 OWN - NLM STAT- Publisher LR - 20260811 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Jun 23 TI - Serum FAM132A/Adipolin correlates with endothelial dysfunction in children with obesity. LID - 10.1038/s41390-026-05240-9 [doi] AB - BACKGROUND: Early cardiovascular risk in children demands biomarkers linking adiposity to vascular injury. We examined whether serum FAM132A (Adipolin) associates with endothelial dysfunction markers in Chinese children with obesity. METHODS: In a STROBE-guided single-center case-control study (Sep 2023-Mar 2024), we enrolled 82 children with obesity and 50 age-matched normal-weight controls; all participants underwent clinical assessment and anthropometry, and serum FAM132A, adiponectin, leptin and endothelial markers VCAM-1, E-selectin and ESM-1 were measured by ELISA. Multiple linear regression tested independent associations with adjustment for age, sex, pubertal stage, HOMA-IR and leptin. RESULTS: Mean FAM132A was higher in the obesity group (0.97 +/- 0.13 vs 0.79 +/- 0.07 ng/ml, p < 0.001) and correlated positively with BMI, SDS-BMI, WHR, ALT and the three endothelial markers. In fully adjusted models FAM132A independently predicted VCAM-1 (beta = 1.110, p = 0.040), E-selectin (beta = 1.210, p = 0.043) and ESM-1 (beta = 1.257, p = 0.041); these associations persisted after accounting for insulin resistance and were independent of classic adipokines. CONCLUSION: Serum FAM132A is paradoxically elevated in pediatric obesity and independently associated with endothelial activation, suggesting compensatory upregulation in early metabolic stress and potential utility as an early vascular injury biomarker and merits longitudinal validation. IMPACT: Serum FAM132A elevated in obese Chinese children. FAM132A correlates with endothelial markers VCAM-1, E-selectin, and ESM-1. Associations independent of insulin resistance and classic adipokines. Suggests compensatory upregulation during early metabolic stress. IMPLICATION: FAM132A as early biomarker for pediatric vascular injury. CI - (c) 2026. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Jin, Yan AU - Jin Y AD - Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. AD - Department of Neonatology, Shaanxi Sen-gong Hospital, Xi'an, Shaanxi, China. FAU - Ding, Yi AU - Ding Y AD - Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Li, Hua AU - Li H AD - Preventive Healthcare Department, Xi'an Children's Hospital, Xi'an, Shaanxi, China. FAU - Lian, Biyao AU - Lian B AD - Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. FAU - Wu, Xiaokang AU - Wu X AD - Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi 'an, Shaanxi, China. FAU - Gao, Ning AU - Gao N AD - Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi 'an, Shaanxi, China. FAU - Zhang, Wen AU - Zhang W AD - Department of Clinical Laboratory Medicine, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi 'an, Shaanxi, China. FAU - Yin, Chunyan AU - Yin C AD - Department of Pediatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China. yinchunyan0624@163.com. LA - eng PT - Journal Article DEP - 20260623 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki. The study protocol was approved by the Institutional Ethics Committee of the Second Affiliated Hospital of Xi'an Jiaotong University (Approval No: 2023144). Written informed consent was obtained from the parents or legal guardians of all participants, and verbal assent was obtained from the children. EDAT- 2026/06/24 00:42 MHDA- 2026/06/24 00:42 CRDT- 2026/06/23 23:21 PHST- 2025/12/08 00:00 [received] PHST- 2026/05/17 00:00 [accepted] PHST- 2026/05/10 00:00 [revised] PHST- 2026/06/24 00:42 [pubmed] PHST- 2026/06/24 00:42 [medline] PHST- 2026/06/23 23:21 [entrez] AID - 10.1038/s41390-026-05240-9 [pii] AID - 10.1038/s41390-026-05240-9 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Jun 23. doi: 10.1038/s41390-026-05240-9. PMID- 42336795 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260813 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 10 IP - 1 DP - 2026 Jun 23 TI - Mealtime behaviours, diet quality and parental stress in children with autism spectrum disorder: a cross-sectional study from Turkiye. LID - 10.1136/bmjpo-2025-004226 [doi] LID - e004226 AB - BACKGROUND: Feeding difficulties in children with Autism Spectrum Disorder (ASD) are prevalent, adversely affecting both the child's nutritional status and the family's psychosocial well-being. This study aimed to examine the interrelationships between mealtime behaviours, diet quality and parental stress in children with ASD. METHODS: A cross-sectional study was conducted with 111 parents of children diagnosed with ASD (mean age: 6.8+/-3.5 years) in Antalya, Turkiye. Data were collected via face-to-face interviews using validated tools (Brief Autism Mealtime Behaviour Inventory (BAMBI), parental mealtime strategies, parental stress scale, Quality of Life questionnaire in autism). Diet quality was evaluated using the Healthy Eating Index-2020, derived from 3-day food consumption records. Multivariate linear regression was used to identify independent predictors of diet quality. RESULTS: The prevalence of poor diet quality was alarmingly high (94.5%). Multivariate regression revealed that problematic mealtime behaviours (BAMBI) were a strong independent predictor of lower diet quality (B=-0.370, p<0.001), even after adjusting for sociodemographic factors. While overall proactive parental strategies positively predicted diet quality, specific accommodative practices like preparing special meals correlated negatively. Furthermore, caregivers of girls reported significantly higher stress (p=0.017) and perceived autism-related burden (p=0.003) compared with caregivers of boys. CONCLUSIONS: Severe mealtime behavioural dysregulation in ASD intrinsically compromises diet quality and elevates parental psychosocial burden. Clinical management requires a multidisciplinary, family-centred approach integrating behavioural feeding support with caregiver stress management. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Ozyildirim, Caner AU - Ozyildirim C AUID- ORCID: 0000-0001-8227-9575 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey. FAU - Karacil Ermumcu, Merve Seyda AU - Karacil Ermumcu MS AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey. FAU - Mutlu, Meryem Ece AU - Mutlu ME AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey. FAU - Baran, Ilgin AU - Baran I AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey. FAU - Salim, Hediye AU - Salim H AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey. FAU - Seremet Kurklu, Nilgun AU - Seremet Kurklu N AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Akdeniz University, Antalya, Turkey nseremetkurklu@akdeniz.edu.tr. LA - eng PT - Journal Article DEP - 20260623 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - *Autism Spectrum Disorder/psychology MH - Child MH - *Stress, Psychological/epidemiology MH - *Feeding Behavior/psychology MH - *Parents/psychology MH - *Meals/psychology MH - Child, Preschool MH - Quality of Life MH - Surveys and Questionnaires MH - *Diet PMC - PMC13295970 OTO - NOTNLM OT - Child Health COIS- Competing interests: None declared. EDAT- 2026/06/24 00:43 MHDA- 2026/06/24 18:35 PMCR- 2026/06/23 CRDT- 2026/06/23 22:33 PHST- 2025/10/30 00:00 [received] PHST- 2026/05/30 00:00 [accepted] PHST- 2026/06/24 18:35 [medline] PHST- 2026/06/24 00:43 [pubmed] PHST- 2026/06/23 22:33 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.1136/bmjpo-2025-004226 [pii] AID - bmjpo-2025-004226 [pii] AID - 10.1136/bmjpo-2025-004226 [doi] PST - epublish SO - BMJ Paediatr Open. 2026 Jun 23;10(1):e004226. doi: 10.1136/bmjpo-2025-004226. PMID- 42336570 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260624 IS - 1001-0742 (Print) IS - 1001-0742 (Linking) VI - 166 DP - 2026 Aug TI - Associations between prenatal exposure to indoor air pollution and ambient particulate matter with infant growth. PG - 648-657 LID - S1001-0742(26)00041-0 [pii] LID - 10.1016/j.jes.2026.01.042 [doi] AB - Despite growing concern, the developmental effects of prenatal exposure to indoor and ambient particulate pollution remain poorly characterized. This study examined their individual and joint associations with infant growth. Embedded in the PKUBC-T birth cohort (initiated in June 2018, China), this study included 1068 mother-infant pairs. The PM(1) and PM(2.5) concentrations from the last menstrual period to delivery were predicted via a validated machine learning model, whereas PM(2.5) constituents' concentrations were derived via a modified Community Multiscale Air Quality Model. Indoor air pollution was assessed via questionnaires covering four dimensions. Infant growth was evaluated using body mass index (BMI) Z-scores and weight-for-length (WFL) Z-scores at one year, with overweight/obesity (OWOB) defined by World Health Organization standards. Generalized linear regression indicated that increased exposure to indoor air pollution was associated with elevated BMI Z-scores (beta = 0.089, 95 % CI: 0.007, 0.171) and WFL Z-scores (beta = 0.094, 95 % CI: 0.013, 0.176) in offspring. PM(1) and PM(2.5) also exhibited positive associations with these growth indicators. Infants whose mothers were exposed to higher levels of organic carbon (OC), elementary carbon (EC), NH(4)(+) and SO(4)(2-) had an elevated risk of overweight/obesity (OWOB). Stratified analyses revealed that joint exposure to PM(1) above the median and indoor air pollution was related to increased infant growth, despite nonsignificant multiplicative interaction effects. Similar joint effects were observed for indoor air pollution and PM(2.5), along with its constituents. This study highlights synergistic harms of combined indoor-outdoor air pollution on infant growth, reinforcing the need for integrated policies targeting indoor combustion and ambient PM reduction to safeguard early-life development. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Lyu, Jinlang AU - Lyu J AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China; Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China. FAU - Li, Tiantian AU - Li T AD - China CDC Key Laboratory of Environment and Population Health, National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China. FAU - Zhou, Shuang AU - Zhou S AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China. FAU - Yuan, Xin AU - Yuan X AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China; Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China. FAU - Bao, Zheng AU - Bao Z AD - Tongzhou Maternal and Child Health Care Hospital of Beijing, Beijing 101101, China. FAU - Han, Na AU - Han N AD - Tongzhou Maternal and Child Health Care Hospital of Beijing, Beijing 101101, China. FAU - Chen, Gongbo AU - Chen G AD - Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne 3800, Australia. FAU - Ji, Yuelong AU - Ji Y AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China; Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China. FAU - Li, Qin AU - Li Q AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China; Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China. FAU - Liu, Jue AU - Liu J AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Wang, Hui AU - Wang H AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China; Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China. FAU - Hu, Jianlin AU - Hu J AD - Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Nanjing University of Information Science & Technology, Nanjing 210044, China. FAU - Liu, Ting AU - Liu T AD - Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control, Collaborative Innovation Center of Atmospheric Environment and Equipment Technology, Nanjing University of Information Science & Technology, Nanjing 210044, China. FAU - Guo, Yuming AU - Guo Y AD - Climate, Air Quality Research Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne 3800, Australia. FAU - Li, Yan AU - Li Y AD - Research Center for Child Health, Department of Child Health Care, Key Laboratory of Birth Regulation and Control Technology of National Health Commission of China, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Qingdao, Shandong 250014, China. FAU - Wang, Hai-Jun AU - Wang HJ AD - Department of Maternal and Child Health, School of Public Health, Peking University, National Health Commission Key Laboratory of Reproductive Health, Beijing 100191, China; Peking University Health Science Center-Weifang Joint Research Center for Maternal and Child Health, Beijing 100191, China. Electronic address: whjun@pku.edu.cn. LA - eng PT - Journal Article DEP - 20260120 PL - Netherlands TA - J Environ Sci (China) JT - Journal of environmental sciences (China) JID - 100967627 RN - 0 (Particulate Matter) RN - 0 (Air Pollutants) SB - IM MH - Humans MH - *Particulate Matter/analysis/adverse effects MH - *Air Pollution, Indoor/statistics & numerical data/adverse effects MH - Female MH - *Maternal Exposure/statistics & numerical data MH - *Air Pollutants/analysis MH - Infant MH - China/epidemiology MH - Pregnancy MH - *Prenatal Exposure Delayed Effects/epidemiology MH - *Child Development/drug effects OTO - NOTNLM OT - Adiposity OT - Air pollution OT - Indoor OT - Infant OT - PM(1) OT - PM(2.5) COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/24 00:45 MHDA- 2026/06/25 00:33 CRDT- 2026/06/23 20:54 PHST- 2025/07/17 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/01/17 00:00 [accepted] PHST- 2026/06/25 00:33 [medline] PHST- 2026/06/24 00:45 [pubmed] PHST- 2026/06/23 20:54 [entrez] AID - S1001-0742(26)00041-0 [pii] AID - 10.1016/j.jes.2026.01.042 [doi] PST - ppublish SO - J Environ Sci (China). 2026 Aug;166:648-657. doi: 10.1016/j.jes.2026.01.042. Epub 2026 Jan 20. PMID- 42336084 OWN - NLM STAT- MEDLINE DCOM- 20260808 LR - 20260808 IS - 1873-6424 (Electronic) IS - 0269-7491 (Linking) VI - 406 DP - 2026 Oct 1 TI - A family-based risk assessment of PBDE exposure using a multi-pathway approach: Integrating diet, dust, air and serum measurements. PG - 128627 LID - S0269-7491(26)00997-8 [pii] LID - 10.1016/j.envpol.2026.128627 [doi] AB - A family-based, multi-matrix exposure assessment for polybrominated diphenyl ethers (PBDEs) was implemented to allow comparison of intake pathways and differentiation between shared household exposure and individual-level determinants. The study comprised 124 participants from 48 South Korean households (48 adolescents, 48 mothers and 28 fathers). PBDEs were analysed in indoor air and dust samples per household, three-day whole-meal composite dietary samples and serum per individual, with sampling conducted between August 2020 and January 2021. Dietary intake was the dominant intake pathway, contributing a median of 85.3% of total summation operatorPBDE estimated daily intake (EDI), followed by dust ingestion (11.9%), air inhalation (1.06%), and dermal absorption (0.026%). Median total EDIs were highest for adolescents (4940 pg/kg body weight/day), followed by fathers (3560 pg/kg bw/day) and mothers (2970 pg/kg bw/day), without significant differences. Exposure variability was primarily individual rather than family-based, with family membership explaining approximately 19% of variability (intraclass correlation coefficient = 0.19). Within families, the median ratio between the highest and lowest exposed individuals was 3.8 and exceeded 10 in the upper quartile. Total EDIs were dominated by higher-brominated congeners, particularly BDE-209, whereas serum profiles showed lower representation of BDE-209, reflecting the differences between short-term intake and longer-term accumulation. Mixture risk characterization using the European Food Safety Authority margin of exposure framework suggested limited population-level health concern. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - McGrath, Thomas J AU - McGrath TJ AD - Institute of Health and Environment, Seoul National University, Seoul, 08826, Republic of Korea. FAU - Mok, Sori AU - Mok S AD - Department of Marine Science and Convergence Technology, Hanyang University ERICA, Ansan, 15588, Republic of Korea. FAU - Lim, Jae-Eun AU - Lim JE AD - Department of Marine Science and Convergence Technology, Hanyang University ERICA, Ansan, 15588, Republic of Korea. FAU - Park, Jeongim AU - Park J AD - Department of Environmental Health Sciences, Soonchunhyang University, Asan, 31538, Republic of Korea. FAU - Choi, Kyungho AU - Choi K AD - Graduate School of Public Health, Seoul National University, Seoul, 08826, Republic of Korea. FAU - Kho, Younglim AU - Kho Y AD - Department of Health, Environment & Safety, Eulji University, Seongnam, 13135, Republic of Korea. FAU - Kim, Sungkyoon AU - Kim S AD - Graduate School of Public Health, Seoul National University, Seoul, 08826, Republic of Korea. FAU - Moon, Hyo-Bang AU - Moon HB AD - Department of Marine Science and Convergence Technology, Hanyang University ERICA, Ansan, 15588, Republic of Korea. Electronic address: hbmoon@hanyang.ac.kr. LA - eng PT - Journal Article DEP - 20260623 PL - England TA - Environ Pollut JT - Environmental pollution (Barking, Essex : 1987) JID - 8804476 RN - 0 (Halogenated Diphenyl Ethers) RN - 0 (Dust) RN - 0 (Environmental Pollutants) RN - 0 (Air Pollutants) SB - IM MH - *Halogenated Diphenyl Ethers/analysis/blood MH - Humans MH - *Dust/analysis MH - Risk Assessment MH - Diet MH - *Environmental Exposure/statistics & numerical data/analysis MH - Republic of Korea MH - Male MH - Adult MH - Female MH - Adolescent MH - Environmental Monitoring MH - *Environmental Pollutants/analysis MH - *Dietary Exposure MH - Air Pollutants/analysis OTO - NOTNLM OT - Human biomonitoring OT - Margin of exposure OT - Multi-pathway exposure OT - Persistent organic pollutants OT - Polybrominated diphenyl ethers (PBDEs) COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/24 00:42 MHDA- 2026/08/08 23:08 CRDT- 2026/06/23 19:32 PHST- 2026/03/25 00:00 [received] PHST- 2026/06/11 00:00 [revised] PHST- 2026/06/21 00:00 [accepted] PHST- 2026/08/08 23:08 [medline] PHST- 2026/06/24 00:42 [pubmed] PHST- 2026/06/23 19:32 [entrez] AID - S0269-7491(26)00997-8 [pii] AID - 10.1016/j.envpol.2026.128627 [doi] PST - ppublish SO - Environ Pollut. 2026 Oct 1;406:128627. doi: 10.1016/j.envpol.2026.128627. Epub 2026 Jun 23. PMID- 42335498 OWN - NLM STAT- MEDLINE DCOM- 20260822 LR - 20260919 IS - 1879-2219 (Electronic) IS - 0966-6362 (Linking) VI - 130 DP - 2026 Oct TI - Effect of the conventional gait model 2 variants on lower-limb kinematics in individuals with cerebral palsy. PG - 110265 LID - S0966-6362(26)00175-X [pii] LID - 10.1016/j.gaitpost.2026.110265 [doi] AB - BACKGROUND: Three-dimensional gait analysis is widely used to support clinical decision-making in individuals with motor impairments. However, kinematic outputs depend strongly on the underlying biomechanical model. The open-source Conventional Gait Model II (CGM2) integrates updates to joint centre estimation (CGM2.1), inverse kinematics (CGM2.2), and cluster-based segment tracking (CGM2.3). While previous work demonstrated consistency among CGM2 variants in typically developing children, their effect in clinical populations remains unknown. This study quantified how CGM2 variants influence gait kinematics in individuals with cerebral palsy (CP). METHODS: Twenty-one individuals with CP (GMFCS I-II) underwent gait analysis using a 12-camera motion capture system and a CGM2.3 marker set. Hip, knee, and ankle kinematics from 487 gait cycles were computed using pyCGM2. Differences between CGM2.1, CGM2.2, and CGM2.3 were evaluated using Mean Absolute Deviation (MAD) and the adjusted coefficient of determination (R(2)). RESULTS: Overall, small differences were observed between model variants. MAD values were typically below 5 degrees for most joints and planes, with high correlation between curves (R(2)>0.7). Hip rotation showed the largest discrepancies, with maximum MAD up to 7.7 degrees when comparing CGM2.2 and CGM2.3. Differences between CGM2.1 and CGM2.3 were greater in the transverse and frontal planes but remained within acceptable limits (<5 degrees ), except for hip rotation. CONCLUSION: The CGM2 variant selection has limited impact on gait kinematics in individuals with CP, and most differences fall within known repeatability error. However, transverse-plane kinematics, particularly hip rotation, should be interpreted with caution when comparing data across CGM2 variants. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Dussault-Picard, C AU - Dussault-Picard C AD - Laboratory of Motion analysis, Physical Medicine and Rehabilitation, University Hospital of Nantes, France. FAU - Sangeux, M AU - Sangeux M AD - Centre for clinical motion analysis, University Children's Hospital Basel, Basel, Switzerland. FAU - Armand, S AU - Armand S AD - Kinesiology Laboratory, Geneva University Hospitals and University of Geneva, Geneva, Switzerland; Centre of Research on skeletal Muscle and Movement, Geneva University Hospitals and University of Geneva, Geneva, Switzerland. FAU - Fonseca, M AU - Fonseca M AD - Centre of Research on skeletal Muscle and Movement, Geneva University Hospitals and University of Geneva, Geneva, Switzerland. FAU - Leboeuf, F AU - Leboeuf F AD - Laboratory of Motion analysis, Physical Medicine and Rehabilitation, University Hospital of Nantes, France; Nantes Universite, CHU de Nantes, Movement - Interactions - Performance, MIP, UR 4334, Nantes 44000, France. Electronic address: fabien.leboeuf@chu-nantes.com. LA - eng PT - Journal Article DEP - 20260619 PL - England TA - Gait Posture JT - Gait & posture JID - 9416830 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology MH - Biomechanical Phenomena MH - Female MH - Male MH - Child MH - *Gait Analysis/methods MH - Hip Joint/physiopathology MH - Adolescent MH - *Lower Extremity/physiopathology MH - Knee Joint/physiopathology MH - Ankle Joint/physiopathology MH - Motion Capture MH - *Gait/physiology MH - *Gait Disorders, Neurologic/physiopathology/etiology MH - Adult OTO - NOTNLM OT - Conventional gait model OT - Gait analysis OT - Inverse kinematics OT - Marker set OT - Segmental pose COIS- Declaration of Competing Interest We confirm that the manuscript has been read and approved by all named authors and that there are no other persons who satisfied the criteria for authorship but are not listed. We further confirm that the order of authors listed in the manuscript has been approved by all of us. We further confirm that any aspect of the work covered in this manuscript that has involved humans has been conducted with the ethical approval of all relevant bodies and that such approvals are acknowledged within the manuscript. EDAT- 2026/06/23 18:34 MHDA- 2026/08/22 23:43 CRDT- 2026/06/23 18:01 PHST- 2026/01/08 00:00 [received] PHST- 2026/04/28 00:00 [revised] PHST- 2026/06/18 00:00 [accepted] PHST- 2026/08/22 23:43 [medline] PHST- 2026/06/23 18:34 [pubmed] PHST- 2026/06/23 18:01 [entrez] AID - S0966-6362(26)00175-X [pii] AID - 10.1016/j.gaitpost.2026.110265 [doi] PST - ppublish SO - Gait Posture. 2026 Oct;130:110265. doi: 10.1016/j.gaitpost.2026.110265. Epub 2026 Jun 19. PMID- 42335426 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260813 IS - 1473-5687 (Electronic) IS - 0954-691X (Linking) VI - 38 IP - 8 DP - 2026 Aug 1 TI - Association between albumin-bilirubin score, model for end-stage liver disease score, platelet-albumin-bilirubin score, and acute-on-chronic liver failure complications: a cross-sectional study in a Chinese population. PG - 959-970 LID - 10.1097/MEG.0000000000003221 [doi] AB - BACKGROUND AND AIMS: Acute-on-chronic liver failure (ACLF) is characterized by acute decompensation and high short-term mortality. We investigated whether the albumin-bilirubin (ALBI) score, model for end-stage liver disease (MELD) score, and platelet-albumin-bilirubin (PALBI) score independently predict major ACLF complications. METHODS: This retrospective cross-sectional study enrolled 2104 ACLF patients (2017-2024) fulfilling Asian Pacific Association for the Study of the Liver 2019 criteria. ALBI, MELD, and PALBI were calculated within 48 h of admission. Multivariable logistic regression, restricted cubic spline, and receiver operating characteristic (ROC) analyses assessed associations with ascites, hepatic encephalopathy, hepatorenal syndrome (HRS), coagulopathy, splenomegaly, and spontaneous bacterial peritonitis. RESULTS: All three scores increased significantly with worsening Child-Pugh class (P < 0.001). Per SD increase, ALBI predicted all six complications with adjusted odds ratios (ORs) ranging from 1.98 to 8.73. MELD showed similar predictive ability (ORs: 2.58-7.26). PALBI quartiles 2 and 3 remained significantly associated with HRS (P = 0.007 and P = 0.011, respectively). Restricted cubic spline revealed nonlinear dose-response relationships (P-nonlinearity < 0.005). ROC area under the curve values were consistently higher for MELD than ALBI and PALBI. Subgroup analyses confirmed stability across age, sex, BMI, smoking, and alcohol use. CONCLUSION: ALBI, MELD, and PALBI scores simply and reliably identify ACLF complications, helping clinicians intensify monitoring and tailor therapy for high-risk patients. CI - Copyright (c) 2026 Wolters Kluwer Health, Inc. All rights reserved. FAU - Xie, Jiejie AU - Xie J AD - Department of Gastroenterology. FAU - Pei, Xiong AU - Pei X AD - Department of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan. FAU - Wang, Longyan AU - Wang L AD - Department of Gastroenterology. FAU - Ma, Xiaopu AU - Ma X AD - Department of Gastroenterology, Affiliated Hospital of Xizang Minzu University, Xianyang City, Shaanxi, China. FAU - Xie, Yan AU - Xie Y AD - Department of Gastroenterology. LA - eng PT - Journal Article DEP - 20260625 PL - England TA - Eur J Gastroenterol Hepatol JT - European journal of gastroenterology & hepatology JID - 9000874 RN - RFM9X3LJ49 (Bilirubin) RN - 0 (Serum Albumin) RN - 0 (Biomarkers) RN - Chinese people SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - *Acute-On-Chronic Liver Failure/blood/complications/diagnosis MH - Retrospective Studies MH - *Bilirubin/blood MH - Middle Aged MH - China/epidemiology MH - Severity of Illness Index MH - *Serum Albumin MH - Predictive Value of Tests MH - ROC Curve MH - Platelet Count MH - Hepatorenal Syndrome/etiology MH - Risk Factors MH - Biomarkers/blood MH - Adult MH - Aged MH - Prognosis MH - Ascites/etiology MH - East Asian People OTO - NOTNLM OT - Albumin-Bilirubin score OT - Chinese cohort OT - Platelet-Albumin-Bilirubin Index score OT - ROC analysis OT - ascites OT - hepatic encephalopathy OT - hepatorenal syndrome OT - model for end-stage liver disease score OT - restricted cubic spline OT - spontaneous bacterial peritonitis OT - threshold effect EDAT- 2026/06/23 18:33 MHDA- 2026/06/23 18:34 CRDT- 2026/06/23 16:03 PHST- 2025/11/15 00:00 [received] PHST- 2026/03/18 00:00 [accepted] PHST- 2026/06/23 18:34 [medline] PHST- 2026/06/23 18:33 [pubmed] PHST- 2026/06/23 16:03 [entrez] AID - 00042737-202608000-00009 [pii] AID - 10.1097/MEG.0000000000003221 [doi] PST - ppublish SO - Eur J Gastroenterol Hepatol. 2026 Aug 1;38(8):959-970. doi: 10.1097/MEG.0000000000003221. Epub 2026 Jun 25. PMID- 42335179 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - Predicting elevated transcranial doppler velocity among patients with sickle cell anemia in Uganda: A cross-sectional study. PG - e0351700 LID - 10.1371/journal.pone.0351700 [doi] LID - e0351700 AB - BACKGROUND: Sickle cell anemia (SCA) is an autosomal recessive blood disorder resulting from a specific point mutation in the beta-globin gene. Over half a million children are born with sickle cell anemia annually. Transcranial Doppler (TCD) velocity is an accurate predictor of the risk of stroke among children with sickle cell anemia. Unfortunately, TCD screening is not routinely done in developing countries due to limited resources. There is a need to develop a model that predicts elevated TCD velocity, utilizing routinely collected data to guide management of children with sickle cell anemia. METHODS: We conducted a cross-sectional study from 1st July 2024-30th August 2024 among children with SCA attending the Sickle Cell Clinic. We developed a risk-prediction model for elevated TCD (>/= 170 cm/s) using sociodemographic, hematological, and clinical factors. We used the least absolute shrinkage and selection operator (LASSO) penalized regression to select the best subset of predictors of increased TCD velocity. Model performance was assessed by determining the discrimination using the area under the curve and calibration by drawing a calibration plot. RESULTS: We enrolled 385 children; the mean age was 10.3 (SD 3.8) years. The prevalence of elevated TCD, defined as >/=170 cm/s was 8.3% (95% CI: 5.8, 11.5; n = 32/385). Using a lambda of 0.008, the final model had 12 predictors. The predictors included neuropathy, red blood cell count, heart rate, age, adherence to hydroxyurea, headache, hematocrit, serum lactate dehydrogenase, gender, malnutrition, blood transfusion, and neutrophils. The model predicted elevated TCD with an AUC of 84.7% (95%CI: 74.7, 90.8). CONCLUSION: We developed and validated a model to predict elevated TCD among children living with SCA in Uganda. Further exploration is needed to assess whether this model predicts stroke. CI - Copyright: (c) 2026 Nayiga et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Nayiga, Doreen AU - Nayiga D AD - Department of Pediatrics and Child Health, Busitema University, Mbale, Uganda. FAU - Mukunya, David AU - Mukunya D AD - Department of Community and Public Health, Busitema University, Mbale, Uganda. FAU - Odoch, Simon AU - Odoch S AD - Department of Pediatrics and Child Health, Busitema University, Mbale, Uganda. FAU - Oguttu, Faith AU - Oguttu F AUID- ORCID: 0009-0006-7481-3321 AD - Department of Community and Public Health, Busitema University, Mbale, Uganda. FAU - Munabi, Ian AU - Munabi I AD - Department of Anatomy, Makerere University, Kampala, Uganda. FAU - Musaba, Milton W AU - Musaba MW AD - Department of Obstetrics and Gynecology, Busitema University, Mbale, Uganda. FAU - Kimbugwe, Charles AU - Kimbugwe C AD - Mbale regional referral hospital, Mbale, Uganda. FAU - Makoko, Brian Tonny AU - Makoko BT AUID- ORCID: 0000-0002-6254-4797 AD - Department of Community and Public Health, Busitema University, Mbale, Uganda. FAU - Babuya, Jonathan AU - Babuya J AUID- ORCID: 0000-0001-7586-3386 AD - Department of Community and Public Health, Busitema University, Mbale, Uganda. FAU - Mugabi, Joshua AU - Mugabi J AD - Department of Community and Public Health, Busitema University, Mbale, Uganda. FAU - Nyalihama, Alain AU - Nyalihama A AD - Department of Pediatrics and Child Health, Busitema University, Mbale, Uganda. FAU - Chebet, Martin AU - Chebet M AD - Department of Pediatrics and Child Health, Busitema University, Mbale, Uganda. FAU - Rynn, Lisa AU - Rynn L AD - Department of Pediatrics and Child Health, Busitema University, Mbale, Uganda. FAU - Kizito, Samuel AU - Kizito S AD - Silver School of Social Work, New York University, New York, New York, United States of America. FAU - Ssentumbwe, Vincent AU - Ssentumbwe V AD - Division of Computational and Data Science, Washington University, St. Louis, Missouri, United States of America. FAU - Kiguli, Sarah AU - Kiguli S AD - Department of Pediatrics and Child Health, Makerere University, Kampala, Uganda. FAU - Olupot, Peter Olupot AU - Olupot PO AUID- ORCID: 0000-0002-5757-609X AD - Department of Community and Public Health, Busitema University, Mbale, Uganda. LA - eng PT - Journal Article DEP - 20260623 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Anemia, Sickle Cell/diagnostic imaging/physiopathology/complications MH - Cross-Sectional Studies MH - Female MH - *Ultrasonography, Doppler, Transcranial/methods MH - Uganda/epidemiology MH - Male MH - Child MH - Blood Flow Velocity MH - Adolescent MH - Stroke/diagnostic imaging/etiology MH - Child, Preschool PMC - PMC13289871 COIS- The authors have declared that no competing interests exist. EDAT- 2026/06/23 18:34 MHDA- 2026/06/23 18:35 PMCR- 2026/06/23 CRDT- 2026/06/23 13:43 PHST- 2025/09/22 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/06/23 18:35 [medline] PHST- 2026/06/23 18:34 [pubmed] PHST- 2026/06/23 13:43 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - PONE-D-25-51516 [pii] AID - 10.1371/journal.pone.0351700 [doi] PST - epublish SO - PLoS One. 2026 Jun 23;21(6):e0351700. doi: 10.1371/journal.pone.0351700. eCollection 2026. PMID- 42335117 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260623 IS - 1533-4287 (Electronic) IS - 1064-8011 (Linking) VI - 40 IP - 7 DP - 2026 Jul 1 TI - Improving Base Running Diagnostics With Foot Pod Technology: Intersession Reliability of Linear and Curvilinear Running Performance. PG - e714-e720 LID - 10.1519/JSC.0000000000005417 [doi] AB - Martinez-Rodriguez, JA, Crotin, RL, Neville, J, Barcelo, RA, and Cronin, JB. Improving base running diagnostics with foot pod technology: Intersession reliability of linear and curvilinear running performance. J Strength Cond Res 40(7): e714-e720, 2026-The purpose of this study was to determine the intersession reliability of foot pod technology for quantifying kinematic measures over the 54.7-m straight-line sprint (linear) and home-to-second base sprint (curvilinear). Twelve, trained male high school baseball position players, performed 3 identical sessions separated by at least 2 days. Eight kinematic measures (maximum speed, average speed and right and left ground contact time, stride length, push-off, and impact) were quantified over 2 linear and 2 curvilinear trials, which were divided into segments-home to first, first to second, and home to second, for a total of 60 comparisons across 3 testing occasions. There was no evidence (p > 0.05) of systematic change in any of the variables between sessions, with 91% of the mean percent changes <2%. In terms of absolute consistency, 94% of coefficients of variation (CVs) were under 10%, with 63% of the CVs under 5%. Regarding relative consistency, for the curvilinear segments 1 and 2, and total segment, 80, 56, and 80% of the between-session comparisons had intraclass correlation coefficients (ICC) greater than 0.74, respectively. The nonsignificant small percentage changes in the mean, low CVs, and good to excellent reliability of the ICCs for the most part indicate that foot pod technology can be used to reliably quantify linear and curvilinear base running performance measures with confidence. Consequently, this information can be used to better quantify base running efficiency and inform exercise prescription to improve base running performance. CI - Copyright (c) 2026 National Strength and Conditioning Association. FAU - Martinez-Rodriguez, Jose Antonio AU - Martinez-Rodriguez JA AUID- ORCID: 0000-0001-8338-2873 AD - Sport Performance Research Institute New Zealand, Auckland University of Technology, Auckland, New Zealand. FAU - Crotin, Ryan L AU - Crotin RL AD - Sport Performance Research Institute New Zealand, Auckland University of Technology, Auckland, New Zealand. AD - Department of Kinesiology, Louisiana Tech University, Ruston, Louisiana. AD - ArmCare.com, Indialantic, Florida; and. FAU - Neville, Jonathon AU - Neville J AD - Sport Performance Research Institute New Zealand, Auckland University of Technology, Auckland, New Zealand. FAU - Barcelo, Roderick A AU - Barcelo RA AD - Athletic Department, Carlos Beltran Baseball Academy, Florida, Puerto Rico. FAU - Cronin, John B AU - Cronin JB AD - Sport Performance Research Institute New Zealand, Auckland University of Technology, Auckland, New Zealand. AD - Athlete Training and Health, Houston, Texas. LA - eng PT - Journal Article DEP - 20260304 PL - United States TA - J Strength Cond Res JT - Journal of strength and conditioning research JID - 9415084 SB - IM MH - Humans MH - *Running/physiology MH - Male MH - Biomechanical Phenomena MH - Reproducibility of Results MH - *Athletic Performance/physiology MH - Adolescent MH - *Baseball/physiology MH - Foot/physiology OTO - NOTNLM OT - high-frequency technology OT - kinematic measures EDAT- 2026/06/23 18:34 MHDA- 2026/06/23 18:35 CRDT- 2026/06/23 13:35 PHST- 2026/06/23 18:35 [medline] PHST- 2026/06/23 18:34 [pubmed] PHST- 2026/06/23 13:35 [entrez] AID - 00124278-202607000-00018 [pii] AID - 10.1519/JSC.0000000000005417 [doi] PST - ppublish SO - J Strength Cond Res. 2026 Jul 1;40(7):e714-e720. doi: 10.1519/JSC.0000000000005417. Epub 2026 Mar 4. PMID- 42334852 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260826 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 9 IP - 6 DP - 2026 Jun 1 TI - Maternal Cardiovascular Health During Pregnancy and Offspring Developmental Delay. PG - e2618804 LID - 10.1001/jamanetworkopen.2026.18804 [doi] LID - e2618804 AB - IMPORTANCE: Developmental delay affects daily living, social functioning, and mental health. Maternal cardiovascular health (CVH) during pregnancy may indicate an adverse intrauterine environment, but its association with developmental delay is unclear. OBJECTIVE: To examine the association between maternal CVH during pregnancy and developmental delay in offspring at 4 years of age. DESIGN, SETTING, AND PARTICIPANTS: This cohort study enrolled patients between July 19, 2013, and March 31, 2017, with 5 years of follow-up, at obstetric hospitals and clinics in Miyagi Prefecture, Japan. Participants included eligible mother and offspring pairs enrolled in the Tohoku Medical Megabank Project Birth and Three-Generation Cohort Study. Offspring were followed up until age 4 years. Data analyses were conducted from November 12, 2024, to March 24, 2026. EXPOSURE: Maternal CVH during pregnancy, which was assessed using Life's Essential 8 metrics (diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, blood glucose, and blood pressure). Each metric was scored on a scale of 0 (least favorable) to 100 (most favorable), and these scores were used to categorize mothers as having high (80-100), moderate (50-79), or low (0-49) CVH. MAIN OUTCOMES AND MEASURES: Developmental delay at age 4 years, which was evaluated by the mother using the validated Japanese version of Ages and Stages Questionnaire, Third Edition. This instrument has 5 domains: communication, gross motor, fine motor, problem solving, and personal-social skills. Domain-specific delay was defined as 2 or more SDs below the mean score, and developmental delay in total was defined as delay in 1 or more of the 5 domains. RESULTS: Among 19 160 eligible mother and offspring pairs, 8238 (43.0%) were analyzed. Offspring were assessed at a mean (SD) age of 4.1 (0.2) years and included 4299 males (52.2%). Among mothers with high, moderate, and low CVH, 154 (8.8%), 763 (12.1%), and 33 (16.8%), respectively, had offspring with developmental delay in total. Compared with high CVH, moderate (risk ratio [RR], 1.30; 95% CI, 1.09-1.54) and low (RR, 1.62; 95% CI, 1.11-2.36) CVH during pregnancy were associated with developmental delay in total. Low CVH was associated with higher prevalence of developmental delay across all 5 domains, with personal-social domain having the largest effect size (RR, 2.23; 95% CI, 1.23-4.07; P for trend = .002) and communication domain having the smallest effect size (RR, 1.40; 95% CI, 0.69-2.85; P for trend = .03). CONCLUSIONS AND RELEVANCE: In this cohort study of mother and offspring pairs in Japan, better maternal CVH during pregnancy was associated with a lower risk of offspring developmental delay at age 4 years. FAU - Ohseto, Hisashi AU - Ohseto H AD - Division of Disaster Public Health, International Research Institute of Disaster Science, Tohoku University, Sendai, Miyagi, Japan. FAU - Ishikuro, Mami AU - Ishikuro M AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Chen, Geng AU - Chen G AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. FAU - Takahashi, Ippei AU - Takahashi I AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. FAU - Shinoda, Genki AU - Shinoda G AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Noda, Aoi AU - Noda A AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Miyagi, Japan. FAU - Murakami, Keiko AU - Murakami K AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Health and Social Behavior, School of Public Health, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. FAU - Orui, Masatsugu AU - Orui M AD - Division of Disaster Public Health, International Research Institute of Disaster Science, Tohoku University, Sendai, Miyagi, Japan. AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Takase, Masato AU - Takase M AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. FAU - Iwama, Noriyuki AU - Iwama N AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Center for Maternal and Perinatal Medicine, Tohoku University Hospital, Sendai, Miyagi, Japan. FAU - Kikuya, Masahiro AU - Kikuya M AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Hygiene and Public Health, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan. FAU - Metoki, Hirohito AU - Metoki H AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Division of Public Health, Hygiene and Epidemiology, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Miyagi, Japan. FAU - Hozawa, Atsushi AU - Hozawa A AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Division of Epidemiology, School of Public Health, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. FAU - Obara, Taku AU - Obara T AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Miyagi, Japan. FAU - Kuriyama, Shinichi AU - Kuriyama S AD - Division of Disaster Public Health, International Research Institute of Disaster Science, Tohoku University, Sendai, Miyagi, Japan. AD - Division of Molecular Epidemiology, Environment and Genome Research Center, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan. AD - Department of Preventive Medicine and Epidemiology, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Miyagi, Japan. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260601 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Adult MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Pregnancy MH - Cohort Studies MH - *Developmental Disabilities/epidemiology/etiology MH - *Developmental Origins of Health and Disease/epidemiology MH - Japan/epidemiology MH - *Maternal Health/statistics & numerical data PMC - PMC13291893 COIS- Conflict of Interest Disclosures: Dr Ishikuro reported receiving grants from Japan Agency for Medical Research and Development and the Ministry of Education, Culture, Sports, Science, and Technology during the conduct of the study. No other disclosures were reported. EDAT- 2026/06/23 12:35 MHDA- 2026/06/23 18:34 PMCR- 2026/06/23 CRDT- 2026/06/23 11:33 PHST- 2026/06/23 18:34 [medline] PHST- 2026/06/23 12:35 [pubmed] PHST- 2026/06/23 11:33 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 2850602 [pii] AID - zoi260523 [pii] AID - 10.1001/jamanetworkopen.2026.18804 [doi] PST - epublish SO - JAMA Netw Open. 2026 Jun 1;9(6):e2618804. doi: 10.1001/jamanetworkopen.2026.18804. PMID- 42334665 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20261010 IS - 1534-3170 (Electronic) IS - 1523-3782 (Linking) VI - 28 IP - 1 DP - 2026 Jun 23 TI - Diagnosis and Management of Loeys-Dietz Syndrome: Evidence Gaps and Future Directions. LID - 61 [pii] LID - 10.1007/s11886-026-02383-3 [doi] AB - PURPOSE OF REVIEW: This review summarizes current knowledge on Loeys-Dietz syndrome (LDS), including its genetic basis, multisystem manifestations, diagnosis, surveillance, and management. It also highlights key evidence gaps in risk stratification, medical therapy, imaging surveillance, surgical thresholds, and care of pregnant and pediatric patients. RECENT FINDINGS: Although understanding of the genetic basis and clinical spectrum of LDS has improved, LDS-specific evidence remains limited. LDS is increasingly recognized as a multisystem disorder with aggressive aortic disease, extra-aortic vascular involvement, skeletal, craniofacial, allergic, gastrointestinal, and neurodevelopmental manifestations. Current recommendations are largely based on expert consensus and experience with related connective tissue disorders. Most available research focuses on the aortic root and ascending aorta, with less evidence guiding management of peripheral vascular disease. LDS requires early diagnosis, individualized risk assessment, and multidisciplinary longitudinal care supported by genetic evaluation, biomarker-based approaches, multimodality imaging, and structured surveillance. Future research should focus on multicenter registries, genotype-phenotype correlations, biomarker validation, advanced imaging, and LDS-specific therapeutic studies to develop evidence-based guidelines and improve long-term outcomes. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Abdalla, Hesham M AU - Abdalla HM AD - Department of Internal Medicine, Mayo Clinic, Phoenix, AZ, USA. FAU - Abdelnabi, Mahmoud AU - Abdelnabi M AD - Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ, USA. Abdelnabi.Mahmoud@mayo.edu. FAU - Khedr, Ahmed AU - Khedr A AD - Department of Cardiovascular Surgery, Mayo Clinic, Phoenix, AZ, USA. FAU - Jamal, Fares AU - Jamal F AD - Department of Hematology and Oncology, Mayo Clinic, Phoenix, AZ, USA. FAU - Nwaezeapu, Karldon Iwuchukwu AU - Nwaezeapu KI AD - Department of Internal Medicine, Trintiy Health, Ann Arbor, MI, USA. FAU - Raslan, Mohammed Alaa AU - Raslan MA AD - Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ, USA. FAU - Ibrahim, Ramzi AU - Ibrahim R AD - Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ, USA. FAU - Pham, Hoang Nhat AU - Pham HN AD - Department of Medicine, University of Arizona, Tucson, AZ, USA. AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. FAU - Pathangey, Girish AU - Pathangey G AD - Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ, USA. FAU - Abdul Nabi, Hussein AU - Abdul Nabi H AD - Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ, USA. FAU - Dreher, Luke AU - Dreher L AD - Department of Internal Medicine, Mayo Clinic, Phoenix, AZ, USA. FAU - Osundiji, Mayowa A AU - Osundiji MA AD - Department of Clinical Genomics, Mayo Clinic, Scottsdale, AZ, 85259, USA. FAU - Coutinho, Thais D AU - Coutinho TD AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN, USA. FAU - Arsanjani, Reza AU - Arsanjani R AD - Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ, USA. FAU - Shamoun, Fadi AU - Shamoun F AD - Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ, USA. FAU - Ayoub, Chadi AU - Ayoub C AD - Department of Cardiovascular Disease, Mayo Clinic, Phoenix, AZ, USA. LA - eng PT - Journal Article PT - Review DEP - 20260623 PL - United States TA - Curr Cardiol Rep JT - Current cardiology reports JID - 100888969 SB - IM MH - Humans MH - *Loeys-Dietz Syndrome/diagnosis/therapy/genetics MH - Female MH - Pregnancy MH - Risk Assessment OTO - NOTNLM OT - Aortic aneurysm OT - Aortic dissection OT - Aortopathies OT - Loeys-dietz syndrome OT - Management OT - Non-skeletal manifestations OT - Pediatric considerations OT - Pregnancy OT - Surveillance OT - TGF-beta signaling COIS- Declarations. Competing interests: The authors declare no competing interests. Human and Animal Rights and Informed Consent: This article does not contain any studies with human, or animal subjects performed by any of the authors. EDAT- 2026/06/23 12:36 MHDA- 2026/06/23 18:34 CRDT- 2026/06/23 11:18 PHST- 2026/06/02 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/06/23 18:34 [medline] PHST- 2026/06/23 12:36 [pubmed] PHST- 2026/06/23 11:18 [entrez] AID - 10.1007/s11886-026-02383-3 [pii] AID - 10.1007/s11886-026-02383-3 [doi] PST - epublish SO - Curr Cardiol Rep. 2026 Jun 23;28(1):61. doi: 10.1007/s11886-026-02383-3. PMID- 42334526 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260922 IS - 2210-6014 (Electronic) IS - 2210-6006 (Print) IS - 2210-6006 (Linking) VI - 16 IP - 1 DP - 2026 Jun 23 TI - Anemia and Cardiometabolic Risk in Indian University Students: Findings from a Health Screening Program. LID - 10.1007/s44197-026-00597-w [doi] LID - 111 AB - BACKGROUND: College students represent a population that is considered clinically at low risk; yet, early adulthood constitutes a crucial time point when nutritional and metabolic risks manifest themselves. This retrospective observational study evaluated anemia, blood pressure, and body mass index (BMI) characteristics of college students undergoing a health screening examination organized by their university in India. METHODS: Anonymized electronic health records were analyzed for 13,628 college students between the ages of 18 and 30 years old attending annual health screening from 1 June 2023 to 31 May 2024. The sample consisted of 77.2% of the eligible students. BMI, blood pressure, and hemoglobin levels were classified according to international standards. Gender-based differences were explored through chi-square tests and Cramer's V measures. Association between anemia and screening-confirmed hypertension was assessed using Pearson correlations and multiple logistic regression. In addition, model discrimination, calibration, classification parameters, and internal validation were evaluated. RESULTS: There were 7,012 (51.5%) female students and 6,616 (48.5%) male students in the sample population. In total, 47.3% of the students were either overweight or obese, 8,081 (59.3%) fulfilled the criteria for high blood pressure according to the ACC/AHA guidelines, while 7,227 (53.0%) fulfilled WHO guidelines for anemia based on gender. Hypertension screening was also more common among men (66.6%) compared to women (52.4%; p < 0.001). In the adjusted models, being male was significantly linked with anemia and hypertension screening, while being overweight was significantly linked with hypertension screening. CONCLUSION: This study showed the high prevalence of undiagnosed anemia and cardiometabolic risks among university students, suggesting the importance of health promoting universities in systematic screening programs and follow-ups. CI - (c) 2026. The Author(s). FAU - Yeravdekar, Rajiv AU - Yeravdekar R AD - Faculty of Medical & Health Sciences, Symbiosis International (Deemed University), Gram Lavale, Pune, Maharashtra, India. FAU - Chandak, Alaka AU - Chandak A AD - Symbiosis Institute of Health Sciences (SIHS), Symbiosis International (Deemed University), Pune, Maharashtra, India. dralaka@sihs.edu.in. AD - , Pune, India. dralaka@sihs.edu.in. LA - eng PT - Journal Article PT - Observational Study DEP - 20260623 PL - Switzerland TA - J Epidemiol Glob Health JT - Journal of epidemiology and global health JID - 101592084 SB - IM MH - Humans MH - Male MH - Female MH - *Students/statistics & numerical data MH - Universities MH - Retrospective Studies MH - Adult MH - Young Adult MH - India/epidemiology MH - *Anemia/epidemiology MH - Mass Screening MH - Adolescent MH - Body Mass Index MH - *Hypertension/epidemiology MH - *Cardiometabolic Risk Factors MH - Blood Pressure PMC - PMC13575005 OTO - NOTNLM OT - Anemia OT - Cardiometabolic risks OT - Electronic medical records OT - Health promoting universities OT - High blood pressure OT - Student health OT - Universities COIS- Declarations. Ethical approval: Ethics approval was obtained from the Institutional Ethics Committee of Symbiosis International (Deemed University), Approval No. SIU/IEC/1137. Consent to participate: The requirement for individual informed consent was waived by the Institutional Ethics Committee because the study used anonymized retrospective EHR data. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 12:36 MHDA- 2026/09/15 05:36 PMCR- 2026/06/23 CRDT- 2026/06/23 11:05 PHST- 2026/03/18 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/09/15 05:36 [medline] PHST- 2026/06/23 12:36 [pubmed] PHST- 2026/06/23 11:05 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.1007/s44197-026-00597-w [pii] AID - 597 [pii] AID - 10.1007/s44197-026-00597-w [doi] PST - epublish SO - J Epidemiol Glob Health. 2026 Jun 23;16(1):111. doi: 10.1007/s44197-026-00597-w. PMID- 42334123 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260905 IS - 1098-240X (Electronic) IS - 0160-6891 (Print) IS - 0160-6891 (Linking) VI - 49 IP - 5 DP - 2026 Oct TI - The Psychometric Properties of the Caregiver Feeding Style Questionnaire: A Cross-Cultural Validation in Spanish Parents. PG - 657-667 LID - 10.1002/nur.70093 [doi] AB - Parental feeding styles are a key dimension of parent-child interactions during mealtimes and have a significant influence on children's development. Through their impact on children's eating behaviours, these styles are a key focus for enhancing the well-being of both the child and the family as a whole. This study aimed to cross-culturally adapt, translate, and validate the Caregiver Feeding Style Questionnaire (CFSQ) in a Spanish sample. This is a cross-sectional study that conducted in a Spanish cohort. Data were collected at four time points, from hospital discharge until the children were aged 7-10 years old. As part of the CFSQ validation study, the original English version underwent linguistic validation, which included 20 cognitive interviews with parents. Confirmatory factor analysis (CFA) of the CFSQ was then conducted using the cohort sample. A total of 194 Spanish parents of children aged 7-10 years old completed the CFSQ. Some items were slightly modified to improve cultural adaptation. Two CFA models were tested: a bidimensional and a unidimensional model. Both showed acceptable fit indices: bidimensional model -X(2) = 3,385.28 (df = 171; p < 0.001), CFI = 0.902, TLI = 0.889, RMSEA = 0.104 (90%CI 0.094-0.115), and SRMR = 0.09; unidimensional model- X(2) = 2,714.22 (df = 78; p < 0.001), CFI = 0.880, TLI = 0.900, RMSEA = 0.145 (90%CI 0.130-0.161), and SRMR = 0.094-. Both models demonstrated adequate internal consistency. In conclusion, the Spanish version of the CFSQ showed adequate structural validity and psychometric properties. While both models were acceptable, the shorter unidimensional version is preferable due to its parsimony and performance. CI - (c) 2026 The Author(s). Research in Nursing & Health published by Wiley Periodicals LLC. FAU - Lozano-Casanova, Mar AU - Lozano-Casanova M AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante, Spain. FAU - Escribano, Silvia AU - Escribano S AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante, Spain. FAU - Oliver-Roig, Antonio AU - Oliver-Roig A AUID- ORCID: 0000-0001-9171-820X AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante, Spain. FAU - Gutierrez-Hervas, Ana AU - Gutierrez-Hervas A AUID- ORCID: 0000-0003-3210-7200 AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante, Spain. FAU - Richart-Martinez, Miguel AU - Richart-Martinez M AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante, Spain. FAU - Sospedra, Isabel AU - Sospedra I AD - Nursing Department, Faculty of Health Sciences, University of Alicante, Alicante, Spain. LA - eng GR - PI14/01549/Instituto de Salud Carlos III/ GR - GRE21-08B/Universidad de Alicante/ PT - Journal Article PT - Validation Study DEP - 20260623 PL - United States TA - Res Nurs Health JT - Research in nursing & health JID - 7806136 SB - IM MH - Humans MH - Child MH - Psychometrics MH - Spain MH - Surveys and Questionnaires/standards MH - Female MH - Cross-Sectional Studies MH - Male MH - Cross-Cultural Comparison MH - Reproducibility of Results MH - *Feeding Behavior/psychology MH - *Parents/psychology MH - *Parent-Child Relations MH - Adult MH - *Caregivers/psychology PMC - PMC13539630 COIS- The authors declare no conflicts of interest. EDAT- 2026/06/23 12:34 MHDA- 2026/09/03 17:36 PMCR- 2026/09/03 CRDT- 2026/06/23 08:32 PHST- 2026/05/18 00:00 [revised] PHST- 2025/11/23 00:00 [received] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/09/03 17:36 [medline] PHST- 2026/06/23 12:34 [pubmed] PHST- 2026/06/23 08:32 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - NUR70093 [pii] AID - 10.1002/nur.70093 [doi] PST - ppublish SO - Res Nurs Health. 2026 Oct;49(5):657-667. doi: 10.1002/nur.70093. Epub 2026 Jun 23. PMID- 42334025 OWN - NLM STAT- Publisher LR - 20260623 IS - 1600-0528 (Electronic) IS - 0301-5661 (Linking) DP - 2026 Jun 23 TI - Implementation of Child Healthy Weight Guidelines in the Dental Setting: A Pilot Study. LID - 10.1111/cdoe.70088 [doi] AB - BACKGROUND: There has been an increasing prevalence of childhood overweight and obesity worldwide and locally, with a quarter of Australian children now considered overweight. To address this, the New South Wales government in Australia released guidelines calling for all public dental services to identify children above a healthy weight and refer them to appropriate services. This study was part of a larger study that aimed to codesign and pilot implementation strategies to facilitate the translation of these guidelines into dental staff's practice. METHODS: A pre-post-test design was used to evaluate the strategies across two health districts in NSW. Strategies were codesigned by dental staff and parents of patients and included linguistically appropriate resources; discharge summaries from referral pathways; refresher training; involvement of dental assistants; templates for longitudinal BMI measures and growth assessment flyers for patients. A validated questionnaire measuring intention to engage in the guidelines and self-reported practice was distributed to interested staff before and after the delivery of strategies (2019-2022). Data describing dental staff's' actual practices over this time were also retrieved from patient information management systems. Descriptive and inferential statistics were used to assess the study outcomes and any differences across districts (n = 16). RESULTS: There was no improvement in behavioural determinants of providing a growth assessment as indicated by the overall intention to engage in Children's Healthy Weight guideline (iCHEW) scale scores, however attitude scores had the largest observed improvement (from 30.1 to 35.2) and this was most pronounced in District 2 (27.2-34.3). A significant improvement in adherence to children's healthy weight guidelines was also seen in District 2 (increase of 20.54%, 95% CI 14.09-27.44). In District 1, children had 1.5 times the odds of receiving a growth assessment if they were treated by a dental officer (OR = 1.54; 95% CI 1.00-1.72). Conversely, children in District 2 had significantly lower odds of receiving a growth assessment if they were treated by a dental officer (OR = 0.203; 95% CI 0.12-0.35) or if they were treated at a satellite clinic (OR = 0.572; 95% CI 0.45-0.73). CONCLUSION: Dental staff can play a key role in addressing childhood overweight and obesity, although this can be challenging. The findings suggested some improvements in behavioural determinants and self-reported behaviours following supportive strategies. Further research to confirm these findings using larger sample sizes is recommended. CI - (c) 2026 The Author(s). Community Dentistry and Oral Epidemiology published by John Wiley & Sons Ltd. FAU - Villarosa, Amy R AU - Villarosa AR AUID- ORCID: 0000-0003-3198-472X AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - National Centre for Epidemiology and Population Health, Australian National University, Canberra, Australian Capital Territory, Australia. AD - Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia. FAU - Maneze, Della AU - Maneze D AUID- ORCID: 0000-0001-6475-8804 AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - School of Nursing, University of Wollongong, Wollongong, New South Wales, Australia. FAU - Ramjan, Lucie AU - Ramjan L AUID- ORCID: 0000-0001-7815-3005 AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia. AD - School of Nursing, University of Wollongong, Wollongong, New South Wales, Australia. FAU - Patterson-Norrie, Tiffany AU - Patterson-Norrie T AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia. AD - School of Medicine, Faculty of Health, Western Sydney University, Sydney, New South Wales, Australia. FAU - Srinivas, Ravi AU - Srinivas R AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia. AD - Oral Health Services, South Western Sydney Local Health District, Sydney, New South Wales, Australia. AD - School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. FAU - Yaacoub, Albert AU - Yaacoub A AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. AD - Oral Health Services, Nepean Blue Mountains Local Health District, Sydney, New South Wales, Australia. FAU - Kumar, Tanya AU - Kumar T AD - School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. AD - Oral Health Services, Nepean Blue Mountains Local Health District, Sydney, New South Wales, Australia. FAU - George, Ajesh AU - George A AUID- ORCID: 0000-0002-6795-2546 AD - Australian Centre for Integration of Oral Health (ACIOH), School of Nursing & Midwifery, Western Sydney University, Sydney, New South Wales, Australia. AD - Ingham Institute for Applied Medical Research, Sydney, New South Wales, Australia. AD - School of Nursing, University of Wollongong, Wollongong, New South Wales, Australia. AD - School of Dentistry, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. LA - eng GR - GNT1168119/National Health and Medical Research Council/ GR - GNT1168119/Western Sydney University/ PT - Journal Article DEP - 20260623 PL - Denmark TA - Community Dent Oral Epidemiol JT - Community dentistry and oral epidemiology JID - 0410263 SB - IM OTO - NOTNLM OT - dental staff OT - dentist OT - guidelines OT - implementation OT - oral health EDAT- 2026/06/23 12:35 MHDA- 2026/06/23 12:35 CRDT- 2026/06/23 08:13 PHST- 2026/04/07 00:00 [revised] PHST- 2024/11/05 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/06/23 12:35 [medline] PHST- 2026/06/23 12:35 [pubmed] PHST- 2026/06/23 08:13 [entrez] AID - 10.1111/cdoe.70088 [doi] PST - aheadofprint SO - Community Dent Oral Epidemiol. 2026 Jun 23. doi: 10.1111/cdoe.70088. PMID- 42333937 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260803 IS - 1758-0854 (Electronic) IS - 1758-0854 (Linking) VI - 18 IP - 3 DP - 2026 Jun TI - Developing a mix-method protocol to assess green space quality for multiage health-related activities. PG - e70176 LID - 10.1111/aphw.70176 [doi] AB - The development of an urban green space (UGS) quality assessment protocol addressing the health-related activities of older adults and children represents a sustainable approach to promoting health and well-being. Although most protocols have been developed for physical activity, few have considered other categories of health-related activities that encompass multiple age groups. This study develops a mixed-method green space for multiage health-related activities (GMHA) protocol to assess UGS quality for older adults, children, and the general population across different health-related activities, including physical activity and social interaction. Five conventional domains of facility, amenity, aesthetics, maintenance, safety, and incivilities audited by systematic observation are integrated with the geospatial domains of natural environments and spatial configuration, supported by unmanned aerial vehicle and space syntax techniques. Seventy UGS samples were tested for interrater reliability via intraclass correlation coefficients. The relative importance of each UGS domain in the protocol was further examined using a spatial autoregressive (SAR) model. Content validity is substantiated by scholarship. Preliminary tests verified quantitative reliability and concurrent validity. SAR results revealed varying associations between UGS domains and multiage health-related activities, highlighting the significance of the environment-individual-activity interaction. GMHA can facilitate targeting UGS quality enhancement across broader contexts and populations to benefit health and well-being. CI - (c) 2026 International Association of Applied Psychology. FAU - Chen, Shuolei AU - Chen S AUID- ORCID: 0000-0002-4891-4077 AD - College of Landscape Architecture, Nanjing Forestry University, Nanjing, China. FAU - Wang, Chongxiao AU - Wang C AUID- ORCID: 0009-0005-8361-8969 AD - College of Environment + Design, University of Georgia, Athens, Georgia, USA. FAU - Cheng, Shi AU - Cheng S AD - College of Architecture, Southeast University, Nanjing, China. FAU - Yang, Zhuoheng AU - Yang Z AD - College of Design and Engineering, National University of Singapore, Singapore, Singapore. FAU - Wang, Yan AU - Wang Y AD - College of Landscape Architecture, Nanjing Forestry University, Nanjing, China. LA - eng GR - 52308066/National Natural Science Foundation of China/ GR - BK20230401/Natural Science Foundation of Jiangsu Province/ GR - 2023M741720/China Postdoctoral Science Foundation/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Appl Psychol Health Well Being JT - Applied psychology. Health and well-being JID - 101502957 SB - IM MH - Humans MH - Reproducibility of Results MH - Aged MH - *Environment Design/standards MH - *Exercise MH - Female MH - Male MH - *Social Interaction OTO - NOTNLM OT - children OT - elder OT - geospatial OT - health and well-beings OT - physical activity OT - social interaction OT - urban green space EDAT- 2026/06/23 12:34 MHDA- 2026/06/23 12:35 CRDT- 2026/06/23 07:54 PHST- 2025/07/07 00:00 [received] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/23 12:35 [medline] PHST- 2026/06/23 12:34 [pubmed] PHST- 2026/06/23 07:54 [entrez] AID - 10.1111/aphw.70176 [doi] PST - ppublish SO - Appl Psychol Health Well Being. 2026 Jun;18(3):e70176. doi: 10.1111/aphw.70176. PMID- 42333529 OWN - NLM STAT- Publisher LR - 20260623 IS - 1536-3724 (Electronic) IS - 1050-642X (Linking) DP - 2026 Jun 24 TI - The Effect of Performance Training on Sideline Concussion Assessments in Adolescent Athletes: A Pilot Investigation. LID - 10.1097/JSM.0000000000001493 [doi] AB - OBJECTIVE: The vestibular ocular motor screen (VOMS) and the Sport Concussion Assessment Tool 6 (SCAT6) are point-of-care concussion assessments administered immediately or soon after sports participation or exercise. To retain validity and accuracy, the results of these tests should not be affected by sporting activity. We assessed the effect on the mVOMS (modified VOMS) and SCAT6 immediately and 20 minutes after performance training in high school athletes. DESIGN: Nonrandomized pilot experimental study. SETTING: High School, Buffalo, NY. PARTICIPANTS: Nonconcussed athletes (n = 23, 39% male, 15.5 +/- 1.0 years). INDEPENDENT VARIABLE: Performance Training (pretraining, post-training, 20 minutes post-training). MAIN OUTCOME MEASURES: mVOMS and SCAT6 scores (standardized assessment of concussion, modified balance error scoring system, timed tandem gait [TTG], dual task tandem gait [DTTG]). RESULTS: TTG (P = 0.005) and DTTG (P = 0.045) improved significantly from prepractice to immediate postpractice and from pretraining to 20 minutes post-training (TTG [P = 0.002], DTTG [P = 0.006]). There were no other differences in SCAT6 or mVOMS scores among the 3 time points. CONCLUSIONS: SCAT6 and mVOMS performance was not adversely affected by moderately intense exercise training in high school athletes. TTG and DTTG performance improved after exercise, consistent with the learning effect. Further research should be conducted across other populations to increase generalizability. Clinicians should be confident that fatigue and exertion from acute performance training activities are not likely to affect the performance of these widely used sideline concussion assessment tools. CI - Copyright (c) 2026 Wolters Kluwer Health, Inc. All rights reserved. FAU - Chizuk, Haley AU - Chizuk H AUID- ORCID: 0000-0003-2113-0536 AD - UBMD Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Amherst, New York. AD - Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Marshall, Kendall AU - Marshall K AD - Sports Medicine Department, Excelsior Orthopaedics, Amherst, New York. FAU - Yunke, Alexander AU - Yunke A AD - Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Kaiser, Ethan AU - Kaiser E AD - Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Thavisin, Tiffany AU - Thavisin T AD - UBMD Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Amherst, New York. FAU - Adebiyi, Halleluyah AU - Adebiyi H AD - Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Sardinia, William AU - Sardinia W AD - Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Tousignant, Joseph R AU - Tousignant JR AD - UBMD Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Amherst, New York. AD - Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Leddy, John AU - Leddy J AD - UBMD Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Amherst, New York. AD - Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Haider, Mohammad N AU - Haider MN AD - UBMD Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Amherst, New York. AD - Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Jain, Rajiv K AU - Jain RK AD - UBMD Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Amherst, New York. AD - Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. LA - eng PT - Journal Article DEP - 20260624 PL - United States TA - Clin J Sport Med JT - Clinical journal of sport medicine : official journal of the Canadian Academy of Sport Medicine JID - 9103300 SB - IM OTO - NOTNLM OT - concussion OT - concussion assessment OT - exercise OT - pediatrics OT - point-of-care assessments COIS- The authors report no conflicts of interest. EDAT- 2026/06/23 11:34 MHDA- 2026/06/23 11:34 CRDT- 2026/06/23 05:52 PHST- 2025/10/27 00:00 [received] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/06/23 11:34 [medline] PHST- 2026/06/23 11:34 [pubmed] PHST- 2026/06/23 05:52 [entrez] AID - 00042752-990000000-00435 [pii] AID - 10.1097/JSM.0000000000001493 [doi] PST - aheadofprint SO - Clin J Sport Med. 2026 Jun 24. doi: 10.1097/JSM.0000000000001493. PMID- 42332988 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260910 IS - 1651-2227 (Electronic) IS - 0803-5253 (Print) IS - 0803-5253 (Linking) VI - 115 IP - 10 DP - 2026 Oct TI - Fasting Biomarkers and Glycated Haemoglobin Identify Children With Excess Weight at Risk of Dysglycaemia and Guide Oral Glucose Tolerance Testing. PG - 2305-2314 LID - 10.1111/apa.70657 [doi] AB - AIM: Childhood obesity has been strongly associated with insulin resistance and dysglycaemia. We aimed to evaluate fasting biomarkers and glycated haemoglobin (HbA1c) for identifying children at risk and guiding the need for oral glucose tolerance testing (OGTT). METHODS: This single-centre study included 475 consecutive children aged 5-18 years with excess weight who underwent OGTT. Insulin resistance and dysglycaemia were defined based on OGTT-derived indices. Fasting glucose (FG), fasting insulin (FI), homeostatic model assessment of insulin resistance (HOMA-IR), homeostatic model assessment of beta-cell function (HOMA-beta), and HbA1c were evaluated. Receiver operating characteristic (ROC) analysis was used to determine optimal cut-offs for predicting dysglycaemia. RESULTS: The cohort comprised 281 girls (59.2%) and 194 boys, with a median age of 13.8 years. Insulin resistance was present in 81.5% (387/475) and dysglycaemia in 18.9% (90/475). FG above the 90th percentile, FI and HOMA-IR above the 97.5th percentile, and HbA1c >/= 39 mmol/mol (5.7%) were significantly associated with dysglycaemia (p < 0.05). ROC analysis for the entire cohort identified FG 5.27 mmol/L, HbA1c 39 mmol/mol, and HOMA-IR 4.88 as significant cut-offs (all p < 0.001). CONCLUSION: Fasting biomarkers and HbA1c identified children with excess weight at risk of dysglycaemia, providing practical thresholds to guide the need for OGTT. CI - (c) 2026 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd. FAU - Sarikaya, Emre AU - Sarikaya E AD - Department of Paediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Turkiye. FAU - Kilci, Fatih AU - Kilci F AUID- ORCID: 0000-0003-4040-7908 AD - Department of Paediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Turkiye. FAU - Murat, Nurhan Ozcan AU - Murat NO AD - Department of Paediatric Endocrinology, Kocaeli City Hospital, Kocaeli, Turkiye. LA - eng PT - Journal Article DEP - 20260622 PL - Norway TA - Acta Paediatr JT - Acta paediatrica (Oslo, Norway : 1992) JID - 9205968 RN - 0 (Biomarkers) RN - 0 (Glycated Hemoglobin) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Female MH - Biomarkers/blood MH - Glucose Tolerance Test MH - Child MH - *Glycated Hemoglobin/analysis/metabolism MH - Male MH - Fasting/blood MH - Child, Preschool MH - Adolescent MH - Insulin Resistance MH - Blood Glucose/analysis MH - *Pediatric Obesity/blood/complications PMC - PMC13552578 OTO - NOTNLM OT - childhood obesity OT - fasting glucose OT - fasting insulin OT - homeostatic model assessment of insulin resistance OT - oral glucose tolerance test COIS- The authors declare no conflicts of interest. EDAT- 2026/06/23 11:37 MHDA- 2026/09/08 17:36 PMCR- 2026/09/08 CRDT- 2026/06/23 03:13 PHST- 2026/04/09 00:00 [revised] PHST- 2026/01/15 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/09/08 17:36 [medline] PHST- 2026/06/23 11:37 [pubmed] PHST- 2026/06/23 03:13 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - APA70657 [pii] AID - 10.1111/apa.70657 [doi] PST - ppublish SO - Acta Paediatr. 2026 Oct;115(10):2305-2314. doi: 10.1111/apa.70657. Epub 2026 Jun 22. PMID- 42332830 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260922 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 12 IP - 1 DP - 2026 Jun 22 TI - Developing new energy intake reference values for the Saudi population. LID - 10.1186/s40795-026-01392-3 [doi] LID - 120 AB - BACKGROUND: This study updates the average requirement for energy intake (AR-EI) for the Saudi population, thereby addressing outdated references. Previous estimates relied on generalized equations and non-specific data, which often led to overestimations. This study aimed to establish new AR-EI values for Saudi population. METHODS: The study methodology combined two complementary approaches to estimate energy requirements. For adults, a factorial approach was used, incorporating physical activity levels observed in the Saudi population along with reference values for body weight and height, applied in published Saudi predictive equations for Basal Metabolic Rate (BMR). For infants, children, and adolescents (0-17 years), the study used Total Energy Expenditure (TEE) predictive equations derived from multi-country doubly labeled water (DLW) studies. RESULTS: After calculating the requirements across different age groups and sexes, the value representing the average that meets the needs of 50% of the population was identified and adopted as the AR-EI. The AR-EI values ranged from 393 kcal/day during the first six months to 778 kcal/day by 12 months for male infants, while female infants required 364-748 kcal/day. Among children and adolescents, AR-EI values ranged from 912 to 3147 kcal/day. For adults, the AR-EI was estimated at 2207 kcal/day for men and 1708 kcal/day for women under current activity levels. With increased physical activity, these requirements rose to 3153 kcal/day for men and 2440 kcal/day for women. CONCLUSIONS: This study identified significant overestimations in previous references owing to the reliance on generalized equations and outdated data. By incorporating Saudi-specific data, these findings provide accurate and practical benchmarks for energy intake. These results serve as a foundation for evidence-based nutritional guidelines, promoting public health and reducing the incidence of diet-related diseases. CI - (c) 2026. The Author(s). FAU - Alhumaidan, Omar AU - Alhumaidan O AD - Saudi Food and Drug Authority (SFDA), Riyadh, Kingdom of Saudi Arabia. oahumaidan@sfda.gov.sa. AD - Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia. oahumaidan@sfda.gov.sa. FAU - Almajwal, Ali AU - Almajwal A AD - Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia. FAU - Alsaif, Mohammed AU - Alsaif M AD - Saudi Food and Drug Authority (SFDA), Riyadh, Kingdom of Saudi Arabia. AD - Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia. LA - eng PT - Journal Article DEP - 20260622 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC13296159 OTO - NOTNLM OT - Body Weight OT - Caloric OT - Energy intake OT - Nutrition OT - Reference Value COIS- Declarations: "The views expressed in this paper are those of the author(s) and do not necessarily reflect those of the SFDA or its stakeholders. Guaranteeing the accuracy and validity of the data is the sole responsibility of the research team." Ethics approval and consent to participate: This study was conducted as a secondary analysis of previously published data on anthropometric reference measurements and reported metabolic rates. No primary data were collected from human participants. The study protocol was reviewed by the Regulatory Research Committee of the Saudi Food and Drug Authority (Reference No. FD-2025-003). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:35 MHDA- 2026/06/23 11:36 PMCR- 2026/06/22 CRDT- 2026/06/23 01:17 PHST- 2025/01/06 00:00 [received] PHST- 2026/06/05 00:00 [accepted] PHST- 2026/06/23 11:36 [medline] PHST- 2026/06/23 11:35 [pubmed] PHST- 2026/06/23 01:17 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1186/s40795-026-01392-3 [pii] AID - 1392 [pii] AID - 10.1186/s40795-026-01392-3 [doi] PST - epublish SO - BMC Nutr. 2026 Jun 22;12(1):120. doi: 10.1186/s40795-026-01392-3. PMID- 42332731 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260921 IS - 1477-7827 (Electronic) IS - 1477-7827 (Linking) VI - 24 IP - 1 DP - 2026 Jun 22 TI - Association of celiac disease with menstrual and hormonal disturbances: a systematic review and meta-analysis. LID - 10.1186/s12958-026-01572-7 [doi] LID - 82 AB - BACKGROUND: Disturbances in the female reproductive system are known extraintestinal manifestations of celiac disease (CD). However, the reliability of the existing literature is limited by small study populations and heterogeneous study designs. This study is the first systematic review and meta-analysis to synthesize all available evidence and provide a comprehensive evaluation of the association between CD and female menstrual and hormonal parameters. METHODS: A systematic literature search was conducted in PubMed, Scopus, and Cochrane Central databases using keywords related to CD, menstrual characteristics, and hormonal markers. Studies published until August 2025 were included. RESULTS: Our analysis demonstrated a significantly higher mean age at menarche in girls with CD compared with controls [pooled mean difference (MD): 0.64 years, 95% confidence interval (CI): 0.32 to 0.95, p = 0.0007), as well as an increased risk of abnormal uterine bleeding [pooled odds ratio (OR): 2.11, 95% CI: 1.23 to 3.63, p < 0.05] and amenorrhea (pooled OR: 4.03, 95% CI: 1.11 to 14.65, p = 0.0394). Menopausal age was not found to be earlier in women with CD (pooled MD: -1.31 years, 95% CI: -3.02 to 0.40, p = 0.1053). Adherence to a gluten-free diet was not associated with age at menarche when adherent and non-adherent patients were compared (pooled MD: 0.56 years, 95% CI: -0.72 to 1.83, p = 0.260). Furthermore, none of the evaluated biochemical hormonal markers (FSH, LH, estradiol, prolactin, and AMH) differed significantly between women with CD and controls. CONCLUSION: This systematic review and meta-analysis reinforces the existing evidence that CD may adversely affect several aspects of menstrual health in women without significantly impacting biochemical hormonal markers. CI - (c) 2026. The Author(s). FAU - Delis, Michail AU - Delis M AD - 1 st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, "Papageorgiou" General Hospital, Thessaloniki, Greece. mdelisa@auth.gr. FAU - Emmanouilidou-Fotoulaki, Elpida AU - Emmanouilidou-Fotoulaki E AD - 1 st Department of Pediatrics, Medical School, Aristotle University of Thessaloniki, "Hippokration" General Hospital, Thessaloniki, Greece. FAU - Iordanidou, Eirini AU - Iordanidou E AD - 1 st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, "Papageorgiou" General Hospital, Thessaloniki, Greece. FAU - Tsimperidis, Achilleas G AU - Tsimperidis AG AD - Gastroenterology and Hepatology Division, 2nd Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, "Hippokration" General Hospital, Thessaloniki, Greece. FAU - Giouleme, Olga AU - Giouleme O AD - Gastroenterology and Hepatology Division, 2nd Propedeutic Department of Internal Medicine, Medical School, Aristotle University of Thessaloniki, "Hippokration" General Hospital, Thessaloniki, Greece. FAU - Goulis, Dimitrios G AU - Goulis DG AD - 1 st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, "Papageorgiou" General Hospital, Thessaloniki, Greece. FAU - Theodoridis, Theodoros AU - Theodoridis T AD - 1 st Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, "Papageorgiou" General Hospital, Thessaloniki, Greece. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260622 PL - England TA - Reprod Biol Endocrinol JT - Reproductive biology and endocrinology : RB&E JID - 101153627 SB - IM MH - Humans MH - *Celiac Disease/complications/physiopathology MH - Female MH - *Menstruation Disturbances/etiology/epidemiology MH - Menarche/physiology PMC - PMC13555964 OTO - NOTNLM OT - Celiac disease OT - Hormonal OT - Menarche OT - Menopause OT - Menstrual OT - Ovarian COIS- Declarations. Ethics approval and consent to participate: Not applicable. This study is a systematic review and meta-analysis of previously published studies and did not involve the collection of new data from human participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:34 MHDA- 2026/09/09 07:07 PMCR- 2026/06/22 CRDT- 2026/06/23 01:12 PHST- 2026/02/17 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/09/09 07:07 [medline] PHST- 2026/06/23 11:34 [pubmed] PHST- 2026/06/23 01:12 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1186/s12958-026-01572-7 [pii] AID - 1572 [pii] AID - 10.1186/s12958-026-01572-7 [doi] PST - epublish SO - Reprod Biol Endocrinol. 2026 Jun 22;24(1):82. doi: 10.1186/s12958-026-01572-7. PMID- 42332665 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260909 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jun 23 TI - Evaluation of the application of three dimensional-printed occlusal splint in conservative treatment of condylar fractures. LID - 10.1186/s12903-026-08927-x [doi] LID - 1505 AB - BACKGROUND: Conservative treatment of condylar fractures requires the use of occlusal splints. However, limited mouth opening, pain, and tooth damage often prevent timely impression taking, which hinders the fabrication of the occlusal splints. Therefore, there is an urgent need for a convenient and new method. The objective of this study is to evaluate the clinical outcomes and feasibility of innovative 3D-printed occlusal splints for the conservative treatment of condylar fractures. METHODS: This was a retrospective observational case series study aimed to investigate the clinical outcomes of 3D-printed occlusal splints in the conservative treatment of condylar fractures. The patients were divided into pediatric, adolescent, and adult groups according to age. The 3D-printed occlusal splint was secured to the maxilla for 2 months. Patients were instructed to perform mouth-opening exercises daily. Mouth opening was recorded before treatment and at the 3-month follow-up. Data were statistically analyzed. RESULTS: After 3 months of follow-up, no patients reported persistent pain, with mouth-opening and masticatory functions recovered. The postoperative mouth opening of all three groups was significantly greater compared with preoperative values, and the difference was statistically significant (P < 0.05). Regarding deviation of the mandible during mouth opening, the adolescent group showed significant improvement postoperatively (P < 0.05), whereas no statistically significant difference was observed in the pediatric group and the adult group. CONCLUSION: The use of a 3D-printed occlusal splint combined with mouth-opening exercises is a feasible approach for the conservative treatment of condylar fractures. CI - (c) 2026. The Author(s). FAU - Zhang, Difei AU - Zhang D AD - State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan, 430079, People's Republic of China. FAU - Lv, Kun AU - Lv K AD - State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan, 430079, People's Republic of China. lvkun@whu.edu.cn. AD - Department of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Wuhan University, Wuhan, 430079, People's Republic of China. lvkun@whu.edu.cn. LA - eng PT - Journal Article PT - Observational Study DEP - 20260623 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Occlusal Splints MH - *Mandibular Condyle/injuries MH - *Printing, Three-Dimensional MH - Adolescent MH - *Mandibular Fractures/therapy MH - Retrospective Studies MH - Female MH - Adult MH - Child MH - Male MH - Young Adult MH - Treatment Outcome MH - *Conservative Treatment PMC - PMC13483849 OTO - NOTNLM OT - Condyle OT - Conservative Treatment OT - Fracture OT - Mandibular OT - Occlusal Splints OT - Three-Dimensional Printing COIS- Declarations. Ethics approval and consent to participate: We have read the Helsinki Declaration and have followed the guidelines in this investigation. A specific informed consent form was designed, and the study was approved by the Medical Ethics Committee of Wuhan University School of Stomatology(No. WDKQ2024C23; No. WDKQ2025C01). All participants in this study provided written informed consent prior to their involvement. Consent for publication: All presentations of case reports have consent for publication. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:36 MHDA- 2026/08/19 14:49 PMCR- 2026/06/23 CRDT- 2026/06/23 01:08 PHST- 2025/11/30 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/08/19 14:49 [medline] PHST- 2026/06/23 11:36 [pubmed] PHST- 2026/06/23 01:08 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.1186/s12903-026-08927-x [pii] AID - 8927 [pii] AID - 10.1186/s12903-026-08927-x [doi] PST - epublish SO - BMC Oral Health. 2026 Jun 23;26(1):1505. doi: 10.1186/s12903-026-08927-x. PMID- 42332646 OWN - NLM STAT- MEDLINE DCOM- 20260924 LR - 20260926 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jun 23 TI - Psychometric properties of the weight self-stigma questionnaire and weight bias internalization scale in postpartum women. LID - 10.1186/s12884-026-09528-w [doi] LID - 1050 AB - BACKGROUND: Weight stigma internalization among postpartum women may differ from other populations owing to childbirth, breastfeeding, and postnatal physical recovery. Two instruments to assess the concept of weight stigma internalization-the Weight Self-Stigma Questionnaire (WSSQ) and the Weight Bias Internalization Scale (WBIS)-have not been validated in postpartum women. This study aims to evaluate and compare the reliability, factor structure, and concurrent validity between the WBIS and WSSQ in Chinese postpartum women. METHODS: A total of 476 postpartum women (mean age 30.96 +/- 4.67 years) completed the WSSQ and WBIS, as well as other relevant measures regarding perceived weight stigma, psychological outcomes, and eating behaviors. Height and weight were used to calculate the body mass index (BMI). Statistical analyses were performed using internal consistency analysis, confirmatory factor analysis, and correlation analysis. RESULTS: Both the WSSQ and the WBIS were found to have excellent internal consistency. In addition, both were associated with postpartum BMI, perceived weight stigma, adverse psychological outcomes, and restrained and emotional eating behaviors. Differently, the two-factor structure of the WSSQ was supported among postpartum women, but the one-factor WBIS was not. CONCLUSION: The WSSQ is a reliable and valid measurement tool for assessing weight stigma internalization in postpartum women. The structure of WBIS requires further validation and modification in future research. CI - (c) 2026. The Author(s). FAU - Pan, Ting AU - Pan T AD - School of Nursing, Changsha Medical University, Changsha, Hunan, China. AD - Xiangya School of Nursing, Central South University, Changsha, Hunan, China. FAU - Peng, Jiayuan AU - Peng J AD - Xiangyin Campus of Xiangxing College, Hunan University of Chinese Medicine, Yueyang, Hunan, China. AD - Hunan Institute of Traffic Engineering, Hengyang, Hunan, China. FAU - Tan, Xiangmin AU - Tan X AD - School of rural health, Monash University, Melbourne, VIC, Australia. FAU - Sun, Mei AU - Sun M AUID- ORCID: 0000-0001-5341-0845 AD - School of Nursing, Changsha Medical University, Changsha, Hunan, China. smnjw2008@126.com. AD - Xiangya School of Nursing, Central South University, Changsha, Hunan, China. smnjw2008@126.com. LA - eng GR - 22-464/China Medical Board Open Competition Program/ GR - 2026RC9046/Hunan Province Science and Technology Innovation Project/ PT - Journal Article PT - Validation Study DEP - 20260623 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - *Postpartum Period/psychology MH - Psychometrics MH - Reproducibility of Results MH - Surveys and Questionnaires MH - *Social Stigma MH - Adult MH - Body Mass Index MH - *Self Concept MH - Factor Analysis, Statistical MH - *Body Weight MH - *Body Image/psychology MH - Emotional Eating MH - China PMC - PMC13602467 OTO - NOTNLM OT - Assessment OT - Postpartum women OT - Psychometric properties OT - Self-stigma OT - Weight bias OT - Weight stigma COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of the School of Nursing, Central South University (Approval No. E2021108). All participants provided verbal and written informed consent before study participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:35 MHDA- 2026/09/24 05:36 PMCR- 2026/06/23 CRDT- 2026/06/23 01:07 PHST- 2024/08/23 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/09/24 05:36 [medline] PHST- 2026/06/23 11:35 [pubmed] PHST- 2026/06/23 01:07 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.1186/s12884-026-09528-w [pii] AID - 9528 [pii] AID - 10.1186/s12884-026-09528-w [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jun 23;26(1):1050. doi: 10.1186/s12884-026-09528-w. PMID- 42332642 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260909 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jun 22 TI - Forensic dental age estimation in a Pakistani population: validation of Atlas methods and development of a population-specific reference model. LID - 10.1186/s12903-026-08994-0 [doi] LID - 1652 AB - BACKGROUND: Accurate age estimation is essential in forensic and clinical contexts, particularly where birth records are unavailable. Dental development assessed through radiographic calcification is considered a reliable indicator. However, atlas-based methods have demonstrated variable accuracy across populations. This study aimed to evaluate the accuracy and agreement of the Schour and Massler chart and the London Atlas, and to develop a population-specific dental development scheme for a Pakistani cohort. METHODS: A cross-sectional forensic validation study was conducted using 700 digital panoramic radiographs of individuals aged 4.0-17.9 years, stratified by age and sex. Dental age was estimated using both methods and compared with the chronological age. The analyses included paired t-tests, correlation, intraclass correlation coefficient, Bland-Altman analysis, and linear regression. The predictive performance was assessed using the mean absolute error and proportions within +/- 1 and +/- 2 years. RESULTS: Both methods demonstrated strong correlations (r > 0.90) and high ICCs (> 0.85). The London Atlas showed lower mean bias (~ 0.2-0.4 years), narrower limits of agreement (+/- 1.5-2.0 years), and higher predictive accuracy (overall R(2) = 0.997; sex-stratified subgroup range: R(2) = 0.92-0.95) than the Schour and Massler method (overall R(2) = 0.982; sex-stratified subgroup range: R(2) = 0.85-0.90). Accuracy within +/- 1 year was higher for the London Atlas (> 75%) compared with Schour and Massler (< 65%), while both exceeded 90% within +/- 2 years. Population-specific analyses revealed a delay in early dental development. CONCLUSIONS: The London Atlas demonstrated superior agreement and predictive performance; however, population-specific variations limit its universal applicability. The newly developed Pak Atlas provides a more accurate reference for forensic age estimation in the Pakistani population, with direct relevance to medico-legal age assessment. CI - (c) 2026. The Author(s). FAU - Faraz, Syed Abul AU - Faraz SA AD - Department of Oral Biology, Liaquat College of Medicine & Dentistry, Karachi, Pakistan. FAU - Ahmed, Imtiaz AU - Ahmed I AD - Department of Orthodontics, Dow Dental College, Dow University of Health Sciences, Karachi, Pakistan. FAU - Zaidi, Syed Jaffar Abbas AU - Zaidi SJA AUID- ORCID: 0000-0002-2564-7818 AD - Department of Oral Biology & Digital Learning Centre, Dow Dental College, Dow University of Health Sciences, Karachi, Sindh, 74200, Pakistan. jaffar.zaidi@duhs.edu.pk. LA - eng PT - Journal Article PT - Validation Study DEP - 20260622 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Radiography, Panoramic MH - Child, Preschool MH - Pakistan MH - Child MH - Female MH - Cross-Sectional Studies MH - Male MH - Adolescent MH - Reference Values MH - *Forensic Dentistry/methods MH - Tooth Calcification PMC - PMC13536816 OTO - NOTNLM OT - Adolescent OT - Age determination by teeth OT - Forensic dentistry OT - Panoramic OT - Radiography OT - Tooth development COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Institutional Review Board of the Dow University of Health Sciences (IRB-843/DUHS/Approval/2017/36). Informed consent was obtained from all participants and/or their legal guardians (s). All experiments were performed in accordance with the relevant guidelines and regulations (such as the Declaration of Helsinki). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:37 MHDA- 2026/09/02 05:36 PMCR- 2026/06/22 CRDT- 2026/06/23 01:07 PHST- 2026/04/19 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/09/02 05:36 [medline] PHST- 2026/06/23 11:37 [pubmed] PHST- 2026/06/23 01:07 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1186/s12903-026-08994-0 [pii] AID - 8994 [pii] AID - 10.1186/s12903-026-08994-0 [doi] PST - epublish SO - BMC Oral Health. 2026 Jun 22;26(1):1652. doi: 10.1186/s12903-026-08994-0. PMID- 42332636 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260908 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 23 TI - Bridging Respiratory Exposures, Asthma, and Environmental Health in Corpus Christi (BREATHE-CC): a prospective cohort study protocol. LID - 10.1186/s12889-026-28265-5 [doi] LID - 2521 AB - BACKGROUND: Childhood asthma disproportionately affects Hispanic children in the United States. Nevertheless, few longitudinal cohorts exist in Gulf Coast communities where environmental exposures may compound sociodemographic vulnerabilities. Corpus Christi, a majority-Hispanic city with high levels of petrochemical industrial operations, reports higher asthma prevalence than state and national averages. BREATHE-CC (Bridging Respiratory Exposures, Asthma, and Environmental Health in Corpus Christi) is a prospective cohort designed to investigate the role of air pollutants, household conditions, and social determinants of health in asthma exacerbations and wheezing phenotypes. METHODS: Approximately 200 children less than 10 years of age with asthma will be enrolled from Driscoll Children's Hospital. Enrolled participants complete baseline assessments and are followed monthly for up to 18 months using a parent-reported modified ISAAC (International Study of Asthma and Allergies in Childhood) questionnaire that captures household exposures, asthma exacerbations, and wheezing episodes. Questionnaire responses will be validated and supplemented with electronic health record (EHR) reviews. Daily air pollutant concentrations (PM(2.5), PM(10), O(3), SO(2)) from the Texas Commission on Environmental Quality (TCEQ) and U.S. Environmental Protection Agency (EPA) monitoring stations will be linked to participants' addresses. Generalized Additive Models (GAMs) and Poisson regressions will assess the associations between air pollutant exposures, household risk factors, asthma exacerbations, and wheezing phenotypes, adjusting for age, sex, body mass index (BMI), and other sociodemographic indicators. Group-Based Trajectory Modeling (GBTM) will identify latent phenotypes of wheezing. DISCUSSION: This is a longitudinal cohort examining Hispanic children residing in the Gulf Coast petrochemical corridor. In particular, the study integrates granular geospatial environmental monitoring to link daily air pollutant exposure levels with asthma exacerbation risk. GBTM will also be used to identify latent wheezing phenotypes, especially focusing on differences between infectious and non-infectious wheezing. Recruitment will occur at a single hospital in the Coastal Bend region with a modest sample size, which may limit generalizability. REGISTRATION: Clinical trial number: not applicable. Open Science Framework [ https://osf.io/tbg6y/overview?view_only=87309518c35b4d78a7bbe79d5fa70ceb ]. CI - (c) 2026. The Author(s). FAU - Warden, Donald E AU - Warden DE AD - College of Nursing and Health Sciences, Texas A&M University - Corpus Christi, Corpus Christi, USA. FAU - Meyers, Aidan AU - Meyers A AD - College of Nursing and Health Sciences, Texas A&M University - Corpus Christi, Corpus Christi, USA. FAU - Almekhlabi, Hiea AU - Almekhlabi H AD - College of Nursing and Health Sciences, Texas A&M University - Corpus Christi, Corpus Christi, USA. FAU - Kuchavaram, Manasa AU - Kuchavaram M AD - College of Nursing and Health Sciences, Texas A&M University - Corpus Christi, Corpus Christi, USA. FAU - Richmond, Erin AU - Richmond E AD - Global Institute for Hispanic Health, Corpus Christi, USA. FAU - Allison-Hoien, Mari AU - Allison-Hoien M AD - Global Institute for Hispanic Health, Corpus Christi, USA. FAU - Jin, Lei AU - Jin L AD - College of Science, Texas A&M University - Corpus Christi, Corpus Christi, USA. FAU - Johnson, Natalie AU - Johnson N AD - School of Public Health, Texas A&M University, College Station, USA. FAU - Roberts, Jon AU - Roberts J AD - Department of Pediatric Pulmonology, Driscoll Children's Hospital, Corpus Christi, USA. FAU - Melaram, Rajesh AU - Melaram R AUID- ORCID: 0000-0001-5223-5993 AD - College of Nursing and Health Sciences, Texas A&M University - Corpus Christi, Corpus Christi, USA. rajesh.melaram@tamucc.edu. LA - eng PT - Journal Article DEP - 20260623 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Air Pollutants) SB - IM MH - Humans MH - *Asthma/epidemiology MH - Prospective Studies MH - *Environmental Exposure/adverse effects/analysis MH - Child MH - Male MH - Child, Preschool MH - Female MH - Air Pollutants/analysis/adverse effects MH - Texas/epidemiology MH - *Environmental Health MH - Respiratory Sounds MH - Infant MH - *Hispanic or Latino/statistics & numerical data MH - Research Design MH - Air Pollution/adverse effects PMC - PMC13540882 OTO - NOTNLM OT - Air pollutants OT - Asthma exacerbation OT - Children OT - Household OT - Wheezing COIS- Declarations. Ethics approval and consent to participate: This study adheres to the Declaration of Helsinki. Ethical approval was granted by the DCHIRB (FY2025-85). Written informed consent is obtained from parents/guardians. Study data are collected and managed using REDCap hosted at Texas A&M University - Corpus Christi. REDCap provides audit trails for tracking data changes and user activity. Furthermore, a data use and management protocol has been developed to secure data access and protect personal identifying information. REDCap study IDs are unique to patients, and the linkage between BREATHE-CC ID and DCH ID will be stored on a separate server accessible only to key study personnel. Patient addresses and date of birth will be anonymized by authorized personnel and transformed into calculated variables (age and geocoded address with a jitter). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:37 MHDA- 2026/09/03 05:37 PMCR- 2026/06/23 CRDT- 2026/06/23 01:07 PHST- 2026/04/25 00:00 [received] PHST- 2026/06/17 00:00 [accepted] PHST- 2026/09/03 05:37 [medline] PHST- 2026/06/23 11:37 [pubmed] PHST- 2026/06/23 01:07 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - 10.1186/s12889-026-28265-5 [pii] AID - 28265 [pii] AID - 10.1186/s12889-026-28265-5 [doi] PST - epublish SO - BMC Public Health. 2026 Jun 23;26(1):2521. doi: 10.1186/s12889-026-28265-5. PMID- 42332628 OWN - NLM STAT- Publisher LR - 20260623 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) DP - 2026 Jun 23 TI - Urinary proteomic profiling identifies candidate biomarkers for pediatric MAFLD in comparison with obesity and healthy controls. LID - 10.1186/s12887-026-07070-4 [doi] AB - PURPOSE: This exploratory pilot study, employing a single-center and cross-sectional design, aimed to characterize urinary protein alterations associated with pediatric metabolic-associated fatty liver disease (MAFLD) and to identify preliminary candidate proteins associated with MAFLD status within a cohort of children with obesity. METHODS: In this single-center, cross-sectional observational study, urine samples were collected from 39 children and assigned to three groups: healthy controls (n = 10), simple obesity (n = 14), and obesity with MAFLD (diagnosed by ultrasonography, n = 15). Data-independent acquisition (DIA)-based quantitative proteomics was performed. After quality control, shared proteins across groups were analyzed by one-way ANOVA and trend clustering. Functional enrichment was conducted using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. Pearson correlation was used to examine associations between key proteins and clinical metabolic indicators. Exploratory discriminatory potential within this cohort was assessed using Receiver operating characteristic (ROC) curves. RESULTS: A total of 2,824 intersecting proteins were identified, and 49 showed significant differences among the three groups. Trend analysis and fold-change filtering (|log(2)FC| > 0.585) identified 19 core proteins with consistent expression gradients across the healthy, obese, and MAFLD groups. Among these, 6-phosphogluconolactonase (PGLS), dipeptidyl peptidase 7 (DPP7), and complement factor I (CFI) demonstrated notable correlations with liver function markers and glucose-lipid metabolic indices. ROC analysis indicated that PGLS provided the strongest discrimination. CONCLUSION: We performed urinary proteomic profiling to characterize metabolic alterations in pediatric MAFLD. Our analysis identified distinct protein signatures across the HC-OB-MAFLD spectrum, highlighting metabolic dysregulation, oxidative stress, and complement activation as primary features of disease progression. While PGLS, DPP7, and CFI emerged as potential biomarkers, PGLS demonstrated the greatest potential for distinguishing MAFLD from simple obesity in this specific cohort. Due to the small sample size (n = 39) and cross-sectional design, these results provide preliminary molecular insights that require large-scale, longitudinal validation to confirm their clinical utility. TRIAL REGISTRATION: International Traditional Medicine Clinical Trial Registry ITMCTR2025001222, December 31, 2024. Retrospectively registered. CI - (c) 2026. The Author(s). FAU - Zhang, Xiaohui AU - Zhang X AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Zhu, Zhongyi AU - Zhu Z AD - Department of Traditional Chinese Medicine, Shenzhen Children's Hospital, Shenzhen, China. FAU - Zhou, Zhaoxin AU - Zhou Z AD - Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China. FAU - Liu, Chang AU - Liu C AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Du, Lina AU - Du L AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Guo, Ziyun AU - Guo Z AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. FAU - Pu, Guowei AU - Pu G AD - Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China. FAU - He, Qiang AU - He Q AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. bch_hq@126.com. FAU - Yang, Yan AU - Yang Y AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China. yy2303@sina.com. LA - eng GR - No. 2024-2-2095/Capital's Funds for Health Improvement and Research/ PT - Journal Article DEP - 20260623 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM OTO - NOTNLM OT - Childhood obesity OT - Metabolic-associated fatty liver disease (MAFLD) OT - Noninvasive biomarkers OT - Pediatrics OT - Urinary proteomics COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Medical Ethics Committee of Beijing Children's Hospital, Capital Medical University (approval No. [2024]-Y-095-D). The study was registered at the International Traditional Medicine Clinical Trial Registry (ITMCTR2025001222) on December 31, 2024 (Retrospectively registered). Written informed consent was obtained from all participating children and their legal guardians prior to enrollment, in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:34 MHDA- 2026/06/23 11:34 CRDT- 2026/06/23 01:07 PHST- 2026/01/27 00:00 [received] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/23 11:34 [medline] PHST- 2026/06/23 11:34 [pubmed] PHST- 2026/06/23 01:07 [entrez] AID - 10.1186/s12887-026-07070-4 [pii] AID - 10.1186/s12887-026-07070-4 [doi] PST - aheadofprint SO - BMC Pediatr. 2026 Jun 23. doi: 10.1186/s12887-026-07070-4. PMID- 42332600 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260904 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jun 22 TI - Self-assessment risk scoring system for early screening of preterm birth in low resource settings. LID - 10.1186/s12884-026-09519-x [doi] LID - 980 AB - INTRODUCTION: Preterm birth is a leading cause of neonatal mortality and morbidity globally. According to the World Health Organization (WHO), 15 million babies were born prematurely in 2010. Indonesia has the fifth-highest number of preterm births in the world, with 675,700 occurring every year. Early screening for preterm birth is crucial, but many health centers in low-resource settings lack the equipment required to do so. This study aims to develop a scoring system that can predict preterm birth based on socio-demographics, nutrition, lifestyle, previous pregnancy history, and maternal condition. The goal is to create a simple, fast, and inexpensive method that can be easily accessed for early screening in low-resource settings. METHODS: This case-control study was conducted between June 2021 and June 2022 at Cipto Mangunkusumo General Hospital, Jakarta. Subjects were categorized into preterm and control groups. Clinical data were obtained through history taking and medical records and analyzed using IBM SPSS 23. Significant variables in bivariate analysis underwent multivariable analysis through logistic regression. The receiver operating characteristics (ROC) indicate how accurately the risk-scoring system performs. The validity of the scoring formula was analyzed using the Hosmer-Lemeshow test. The performance of the score was assessed using the area under the curve parameter. RESULTS: Multivariate analysis showed that socioeconomic level, antenatal visits, history of preterm, hypertension, and weight gain during pregnancy were independent predictors of preterm birth, with an area under the curve of 0.844 (95% CI 0.802-0.885) and p < 0.001, indicating a good predictive ability. Hosmer-Lemeshow test showed a well-fitted model (p = 0.26). Based on the scoring system in this study, the cut-off >/= 4 had a sensitivity and specificity of 81.3% and 82.2%, respectively, in predicting preterm birth. CONCLUSION: Socioeconomic level, history of preterm delivery, antenatal visits, weight gain during pregnancy, and history of hypertension were independent predictors associated with preterm birth. CI - (c) 2026. The Author(s). FAU - Novianti, Lisa AU - Novianti L AUID- ORCID: 0009-0007-5156-8412 AD - Obstetrics and Gynaecology Department, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia. FAU - Irwinda, Rima AU - Irwinda R AUID- ORCID: 0000-0002-6260-6273 AD - Maternal Fetal Division, Obstetrics and Gynaecology Department, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia. rima.irwinda@yahoo.com. FAU - Saroyo, Yudianto Budi AU - Saroyo YB AD - Maternal Fetal Division, Obstetrics and Gynaecology Department, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia. FAU - Hiksas, Rabbania AU - Hiksas R AUID- ORCID: 0000-0001-8740-3918 AD - Obstetrics and Gynaecology Department, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia. LA - eng PT - Journal Article DEP - 20260622 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - *Premature Birth/diagnosis/epidemiology MH - Indonesia/epidemiology MH - Pregnancy MH - Case-Control Studies MH - Risk Assessment/methods MH - Resource-Limited Settings MH - Adult MH - Infant, Newborn MH - ROC Curve MH - Risk Factors PMC - PMC13536780 OTO - NOTNLM OT - Preterm birth OT - Risk-scoring COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethical Committee of the Faculty of Medicine Universitas Indonesia (Letter number S. 71/SPE/IX/2022). This was a retrospective study, thus only clinically relevant information from medical records were restricted. Written informed consent from all participants was waived by the Ethical Committee as this study also did not affect patients' treatment and health. Consent for publication: No consent was taken from patients during their enrollment into the study. Competing interests: The authors declare no competing interests. EDAT- 2026/06/23 11:35 MHDA- 2026/09/02 05:36 PMCR- 2026/06/22 CRDT- 2026/06/23 01:06 PHST- 2024/03/13 00:00 [received] PHST- 2026/06/15 00:00 [accepted] PHST- 2026/09/02 05:36 [medline] PHST- 2026/06/23 11:35 [pubmed] PHST- 2026/06/23 01:06 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1186/s12884-026-09519-x [pii] AID - 9519 [pii] AID - 10.1186/s12884-026-09519-x [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jun 22;26(1):980. doi: 10.1186/s12884-026-09519-x. PMID- 42332536 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260926 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 25 DP - 2026 Jun 19 TI - Association of triglyceride to high-density lipoprotein cholesterol and low-density lipoprotein to high-density lipoprotein cholesterol ratios with glycemic control in type 2 diabetes mellitus: A cross-sectional study from a Libyan clinical cohort. PG - e49337 LID - 10.1097/MD.0000000000049337 [doi] LID - e49337 AB - Poor glycemic control in type 2 diabetes mellitus (T2DM) is frequently associated with adverse lipid profiles, including elevated triglycerides (TG) and low high-density lipoprotein cholesterol (HDL-C). Lipid ratios, including TG/HDL-C (triglycerides/high-density lipoprotein cholesterol) and LDL-C/HDL-C (low-density/ high-density lipoprotein cholesterol), may serve as simple markers of insulin resistance and cardiometabolic risk. This study aimed to investigate the association between glycemic control and lipid parameters, including TG, HDL-C, and lipid ratios, in a Libyan cohort of T2DM patients. In this retrospective cross-sectional study, 363 T2DM patients (140 males, 223 females) aged 18 to 80 years attending a diabetic polyclinic in Benghazi between January 2022 and January 2024 were included. Clinical and biochemical data, including fasting lipid profiles and glycated hemoglobin (HbA1c), were extracted from patient records. Participants were classified according to glycemic control (HbA1c < 7% vs >/=7%). Associations between lipid parameters, lipid ratios, and glycemic control were assessed using multivariable logistic regression adjusted for age, sex, BMI, duration of diabetes, and statin use. Patients with uncontrolled HbA1c (>/=7%) had significantly higher TG/HDL-C ratios (3.79 +/- 2.52 vs 2.92 +/- 2.42; P = .007) and LDL-C/HDL-C ratios (2.55 +/- 1.30 vs 1.95 +/- 1.05; P < .001) compared with those with controlled HbA1c. In multivariable logistic regression analysis, higher low-density lipoprotein cholesterol (LDL-C) levels were significantly associated with uncontrolled HbA1c (OR = 1.02; 95% CI: 1.01-1.03; P < .001). When lipid ratios were evaluated, the LDL-C/HDL-C ratio remained significantly associated with uncontrolled HbA1c (OR = 1.05; 95% CI: 1.02-1.09; P = .003). Lipid ratios, particularly LDL-C/HDL-C, were associated with poor glycemic control in type 2 diabetes mellitus; however, their clinical utility requires further validation in prospective studies. Integrated management of dyslipidemia and glycemic control is essential to reduce cardiovascular complications in this population. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Mahmoud, Sahar H AU - Mahmoud SH AUID- ORCID: 0009-0003-4715-1244 AD - Department of Physiology, Faculty of Medicine, Benghazi University, Benghazi, Libya. FAU - Elfargani, Fatma R AU - Elfargani FR AD - Department of Physiology, Faculty of Medicine, Benghazi University, Benghazi, Libya. FAU - Mohamed, Nagwa AU - Mohamed N AD - Department of Physiology, Faculty of Medicine, Benghazi University, Benghazi, Libya. FAU - Khader, Yousef AU - Khader Y AD - Department of Public Health, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - 0 (Triglycerides) RN - 0 (Cholesterol, HDL) RN - 0 (Glycated Hemoglobin) RN - 0 (Cholesterol, LDL) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/blood MH - Female MH - Male MH - Cross-Sectional Studies MH - *Triglycerides/blood MH - Middle Aged MH - *Cholesterol, HDL/blood MH - Retrospective Studies MH - *Glycemic Control MH - Aged MH - Glycated Hemoglobin/analysis MH - Aged, 80 and over MH - *Cholesterol, LDL/blood MH - Adult MH - Libya MH - Blood Glucose MH - Young Adult MH - Adolescent PMC - PMC13286382 OTO - NOTNLM OT - HDL-C OT - LDL-C/HDL-C ratio OT - TG/HDL-C ratio OT - dyslipidemia OT - glycemic control OT - inflammation OT - triglycerides OT - type 2 diabetes mellitus COIS- The authors have no funding and conflicts of interest to declare. EDAT- 2026/06/23 11:35 MHDA- 2026/06/23 12:34 PMCR- 2026/06/19 CRDT- 2026/06/23 01:02 PHST- 2026/03/12 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/06/23 12:34 [medline] PHST- 2026/06/23 11:35 [pubmed] PHST- 2026/06/23 01:02 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 00005792-202606190-00098 [pii] AID - MD-D-26-03886 [pii] AID - 10.1097/MD.0000000000049337 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jun 19;105(25):e49337. doi: 10.1097/MD.0000000000049337. PMID- 42332484 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260821 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 25 DP - 2026 Jun 19 TI - Agreement and clinical relevance of mid-upper arm circumference in acute, chronic, and concurrent pediatric malnutrition: A retrospective cross-sectional study. PG - e49335 LID - 10.1097/MD.0000000000049335 [doi] LID - e49335 AB - Mid-upper arm circumference (MUAC) is widely used for screening pediatric malnutrition due to its simplicity and feasibility. Although its relationship with anthropometric indicators including weight-for-height (WFH), body mass index (BMI)-for-age, and height-for-age has been previously examined, the degree of agreement and its clinical implications remain variable. This study aimed to evaluate the agreement and clinical relevance of MUAC in assessing acute, chronic, and concurrent malnutrition. This retrospective cross-sectional study included 473 children (0-18 years) evaluated for malnutrition at a tertiary pediatric gastroenterology clinic. Nutritional status was classified using World Health Organization growth standards based on WFH, BMI-for-age, and height-for-age z-scores. MUAC was analyzed as absolute values and MUAC-for-age z-score categories. Acute malnutrition was identified in 72.9% of participants, chronic malnutrition in 18.2%, and concurrent malnutrition in 8.9%. MUAC classified 83.7% of children as malnourished and detected a higher proportion of mild malnutrition than BMI-for-age and WFH classifications. MUAC severity showed a moderate correlation with WFH classifications in children <5 years (rho = 0.447, P <.001) and a strong correlation with BMI-for-age classifications in those >/= 5 years (rho = 0.649, P <.001). Agreement between MUAC-based severity categories and anthropometric classifications was fair for WFH (kappa = 0.33) and moderate for BMI-for-age (kappa = 0.55). Children with concurrent malnutrition were more frequently classified into moderate or severe MUAC categories (P <.01). MUAC showed fair-to-moderate agreement and moderate-to-strong correlations with BMI-for-age and WFH indicators of acute malnutrition, whereas its associations with chronic malnutrition were weaker. It identifies a higher proportion of children with mild malnutrition and reflects the severity of concurrent malnutrition. These findings support the potential complementary role of MUAC in routine anthropometric assessment and suggest that it may contribute to the early identification of pediatric malnutrition. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Arslan, Melike AU - Arslan M AUID- ORCID: 0000-0002-0107-4699 AD - Division of Pediatric Gastroenterology, Department of Pediatrics, Konya City Hospital, Konya, Turkiye. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Cross-Sectional Studies MH - Retrospective Studies MH - Child, Preschool MH - *Arm/anatomy & histology MH - Infant MH - Female MH - Male MH - Body Mass Index MH - Child MH - *Anthropometry/methods MH - Adolescent MH - *Malnutrition/diagnosis MH - *Child Nutrition Disorders/diagnosis MH - Chronic Disease MH - Nutritional Status MH - Acute Disease MH - Infant, Newborn PMC - PMC13286424 OTO - NOTNLM OT - acute malnutrition OT - anthropometric assessment OT - concurrent malnutrition OT - mid-upper arm circumference (muac) OT - pediatric malnutrition COIS- The authors has no funding and conflicts of interest to declare. EDAT- 2026/06/23 11:37 MHDA- 2026/06/23 18:34 PMCR- 2026/06/19 CRDT- 2026/06/23 01:02 PHST- 2026/03/09 00:00 [received] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/06/23 18:34 [medline] PHST- 2026/06/23 11:37 [pubmed] PHST- 2026/06/23 01:02 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 00005792-202606190-00046 [pii] AID - MD-D-26-03621 [pii] AID - 10.1097/MD.0000000000049335 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jun 19;105(25):e49335. doi: 10.1097/MD.0000000000049335. PMID- 42331937 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20261005 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 22 TI - Correlation analysis of blood metabolites and periventricular leukomalacia in preterm infants two weeks postnatally. LID - 10.1038/s41598-026-58150-5 [doi] LID - 28434 AB - Periventricular leukomalacia (PVL) is a neonatal brain injury disease that may cause neurodevelopmental disorders. In this study, our objective was to compare the differences in blood metabolites between preterm infants with and without PVL. We also aimed to screen for potential metabolic markers related to the early identification of PVL. Preterm infants diagnosed with periventricular leukomalacia (PVL) by cranial imaging were assigned to the PVL group (n = 32), while those without a PVL diagnosis were assigned to the control group (n = 68). Blood metabolite levels were measured at 2 weeks postnatally using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Most blood metabolite concentrations were statistically different between the two groups (P < 0.05). The results of the OPLS-DA model identification analysis and validation show that the model is valid. Of the 12 blood metabolites with predicted variable importance (VIP) > 1, those with the highest VIP scores included octadecadienoylcarnitine (C18:2), 3-hydroxy-isovalerylcarnitine (C4DC), 3-oH-octadecylcarnitine (C18OH), 3-hydroxy-cetacylcarnitine (C16OH), Adipylcarnitine (C6DC), and Tyrosine (Tyr). The S-plot shows that the blood metabolites C4DC, Ornithine (Orn), C16OH, and C18:2 are biased towards the two poles. The univariate analysis for cross-validation showed that C18:2, C4DC, C18OH, and C16OH concentrations in blood metabolites were significantly different between the two groups (P < 0.001). The results of multivariate logistic regression analysis showed that a high concentration of Tyr was negatively associated with the occurrence of PVL (P = 0.031), while a longer duration of parenteral nutrition (PN) and a higher Orn concentration were positively correlated with PVL (all P < 0.05). Receiver Operating Characteristic (ROC) curve analysis indicated that C18:2 had a relatively high discriminatory ability for PVL among the detected metabolites, but it did not show independent statistical significance in the multivariate logistic regression analysis. The most significant difference in the blood metabolite concentrations between the two groups was observed for C18:2. Enrichment analysis showed that fatty acid degradation is the most likely major mechanistic pathway involved in the development of PVL. There is a certain correlation between early blood metabolite levels and PVL occurrence in premature infants. Although C18:2 shows a certain discriminatory ability, the value of it as an early detection indicator still needs further research. CI - (c) 2026. The Author(s). FAU - Zhang, Caiyu AU - Zhang C AD - Department of Neonatology, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Henan, China. FAU - Yu, Muchun AU - Yu M AD - Department of Neonatology, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Henan, China. FAU - He, Lu AU - He L AD - Department of Neonatology, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Henan, China. FAU - Sun, Zhihong AU - Sun Z AD - Department of Neonatology, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Henan, China. FAU - Sun, Huiqing AU - Sun H AD - Department of Neonatology, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Henan, China. s_huiqing@sina.com. LA - eng GR - YXKC2021022/Henan Province Young and Middle-Aged Health Science and Technology Innovation Leading Talent Training Project/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260622 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Leukomalacia, Periventricular/blood/diagnosis MH - Infant, Newborn MH - Female MH - Male MH - *Infant, Premature/blood MH - Biomarkers/blood MH - Tandem Mass Spectrometry PMC - PMC13562565 OTO - NOTNLM OT - Gestational age OT - Metabolites OT - Periventricular leukomalacia OT - Preterm infants OT - Tyrosine COIS- Declarations. Competing interests: The authors have no relevant financial or non-financial interests to disclose. Ethical approval: This study was approved by the Ethics Committee of Henan Children's Hospital (approval number: 2024- KY- 0030) and followed the principles of the Declaration of Helsinki. The purpose and details of the study were explained to the families of all infants participating in the study, and written informed consent was signed. Consent for publication: All authors, parents or legal guardians of the child have consented to publication. EDAT- 2026/06/23 00:34 MHDA- 2026/09/11 05:36 PMCR- 2026/06/22 CRDT- 2026/06/22 23:37 PHST- 2025/11/25 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/09/11 05:36 [medline] PHST- 2026/06/23 00:34 [pubmed] PHST- 2026/06/22 23:37 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1038/s41598-026-58150-5 [pii] AID - 58150 [pii] AID - 10.1038/s41598-026-58150-5 [doi] PST - epublish SO - Sci Rep. 2026 Jun 22;16(1):28434. doi: 10.1038/s41598-026-58150-5. PMID- 42331896 OWN - NLM STAT- Publisher LR - 20260622 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) DP - 2026 Jun 22 TI - Comprehensive behavioral and demographic correlates in myopia risk among Tibetan adolescents: a machine learning analysis using non‑cycloplegic refraction. LID - 10.1038/s41598-026-58744-z [doi] AB - Myopia is a global public health concern, especially among children and adolescents. This exploratory study aimed to develop a myopia risk prediction model for Tibetan adolescents using interpretable machine learning, while explicitly acknowledging the methodological limitations of non-cycloplegic refraction and self-reported data. We included 735 Tibetan adolescents. An XGBoost algorithm was used to build a binary classification model, with the SHAP method applied for feature interpretation. Data were split into 80% training and 20% test sets to analyze associations between behavioral, demographic factors, and myopia risk. Myopia was defined using non-cycloplegic autorefraction (uncorrected visual acuity < 5.0 [logMAR 0.0] and spherical equivalent /=50% reduction in seizure frequency or seizure freedom at six months. EEG changes were compared between responders and non-responders, and receiver operating characteristic analysis was performed to evaluate the association between early EEG changes and clinical outcome. RESULTS: Thirty-four patients were included, of whom 23 (67.6%) were classified as responders at six months. Baseline EEG characteristics did not differ between responders and non-responders. At one month, responders showed a significant reduction in IED index, whereas no significant change was observed in non-responders. A reduction in IED index of approximately 40% was associated with clinical response, demonstrating good discriminative performance. Changes in background EEG activity were observed in both groups and were not associated with seizure outcome. CONCLUSION: Early reduction in IED index on routine sleep EEG is associated with favorable clinical response to the ketogenic diet. Routine EEG assessment may offer supportive electrophysiological information during early follow-up of KD therapy in pediatric drug-resistant epilepsy. CI - Copyright (c) 2026 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved. FAU - Yavuz, Merve AU - Yavuz M AD - Izmir University of Health Sciences Dr. Behcet Uz Children's Health and Surgery Hospital, Department of Pediatric Neurology. Electronic address: drmerveyavuz@hotmail.com. FAU - Unalp, Aycan AU - Unalp A AD - Izmir University of Health Sciences Dr. Behcet Uz Children's Health and Surgery Hospital, Department of Pediatric Neurology. Electronic address: aycan.unalp67@gmail.com. FAU - Gulagiz, Feyza AU - Gulagiz F AD - Izmir University of Health Sciences Dr. Behcet Uz Children's Health and Surgery Hospital, Department of Pediatric Neurology. Electronic address: feyzagulagiz@gmail.com. FAU - Guzin, Yigithan AU - Guzin Y AD - Izmir University of Health Sciences Dr. Behcet Uz Children's Health and Surgery Hospital, Department of Pediatric Neurology. Electronic address: yguzin@hotmail.com. FAU - Yilmaz, Unsal AU - Yilmaz U AD - Izmir University of Health Sciences Dr. Behcet Uz Children's Health and Surgery Hospital, Department of Pediatric Neurology. Electronic address: drunsalyilmaz@yahoo.com. LA - eng PT - Journal Article DEP - 20260610 PL - England TA - Seizure JT - Seizure JID - 9306979 SB - IM MH - Humans MH - *Diet, Ketogenic/methods MH - Male MH - *Electroencephalography MH - Female MH - *Drug Resistant Epilepsy/diet therapy/physiopathology MH - Retrospective Studies MH - Child MH - Treatment Outcome MH - Child, Preschool MH - *Brain/physiopathology MH - Adolescent MH - Seizures/physiopathology/diet therapy OTO - NOTNLM OT - Epilepsy OT - Interictal epileptiform discharge index OT - Ketogenic diet COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/22 21:07 MHDA- 2026/07/16 12:40 CRDT- 2026/06/22 18:08 PHST- 2026/02/11 00:00 [received] PHST- 2026/05/02 00:00 [revised] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/07/16 12:40 [medline] PHST- 2026/06/22 21:07 [pubmed] PHST- 2026/06/22 18:08 [entrez] AID - S1059-1311(26)00176-7 [pii] AID - 10.1016/j.seizure.2026.06.004 [doi] PST - ppublish SO - Seizure. 2026 Aug;140:149-156. doi: 10.1016/j.seizure.2026.06.004. Epub 2026 Jun 10. PMID- 42330798 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1878-7487 (Electronic) IS - 1752-928X (Linking) VI - 121 DP - 2026 Jul TI - Dental age estimation in the Chhattisgarhi population: A comparative study of Demirjian and Willems methods. PG - 103195 LID - S1752-928X(26)00127-7 [pii] LID - 10.1016/j.jflm.2026.103195 [doi] AB - BACKGROUND: Forensic identification, pediatric dentistry, and medico-legal investigations all often utilize dental age estimation. Demirjian and Willems methods are frequently used when estimating dental maturity; however, their accuracy varies across different groups, pointing to the need for population specific validation. AIM: Aim of the current study was to compare and assess the reliability of the Demirjian and Willems for estimating dental age in the children from the Indian state of Chhattisgarh. METHODS: A retrospective cross-sectional study was conducted using 142 orthopantomograms of children aged 10-16 years. Dental age was estimated using Demirjian and Willems methods based on the developmental stages of the seven left mandibular permanent teeth. The accuracy was assessed using mean error (ME) and mean absolute error (MAE). Pearson correlation and paired t-tests were used to evaluate statistical analysis. RESULTS: The Demirjian method showed a tendency to overestimate age in younger individuals and underestimate age in older age groups. The Willems method demonstrated comparatively smaller deviations from chronological age and often yielded better and more reliable age estimates. Both methods show positive correlation between chronological age and dental age. CONCLUSION: The Willems method showed higher accuracy than the Demirjian method in this Chhattisgarhi population for dental age estimation. CI - Copyright (c) 2026 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved. FAU - Tiwari, Archana AU - Tiwari A AD - Department of Forensic Medicine and Toxicology All India Institute of Medical Sciences Raipur, Chhattisgarh, 492099, India. Electronic address: stiwari98archana@gmail.com. FAU - Indurkar, Shubham Kumar AU - Indurkar SK AD - Department of Forensic Medicine and Toxicology Raipur Institute of Medical Sciences, Raipur, Chhattisgarh, 493441, India. Electronic address: shubhamindurkar55@gmail.com. FAU - Chavali, Krishnadutt AU - Chavali K AD - Department of Forensic Medicine and Toxicology All India Institute of Medical Sciences Raipur, Chhattisgarh, 492099, India. Electronic address: drkhchavali@aiimsraipur.edu.in. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260621 PL - England TA - J Forensic Leg Med JT - Journal of forensic and legal medicine JID - 101300022 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Child MH - Radiography, Panoramic MH - Adolescent MH - Retrospective Studies MH - India MH - Cross-Sectional Studies MH - Male MH - Female MH - Reproducibility of Results MH - Forensic Dentistry MH - *Tooth/growth & development/diagnostic imaging MH - Tooth Calcification OTO - NOTNLM OT - Demirjian method OT - Dental age estimation OT - Forensic odontology OT - Orthopantomogram OT - Willems method EDAT- 2026/06/22 21:07 MHDA- 2026/07/07 18:56 CRDT- 2026/06/22 18:07 PHST- 2026/05/29 00:00 [received] PHST- 2026/06/18 00:00 [revised] PHST- 2026/06/20 00:00 [accepted] PHST- 2026/07/07 18:56 [medline] PHST- 2026/06/22 21:07 [pubmed] PHST- 2026/06/22 18:07 [entrez] AID - S1752-928X(26)00127-7 [pii] AID - 10.1016/j.jflm.2026.103195 [doi] PST - ppublish SO - J Forensic Leg Med. 2026 Jul;121:103195. doi: 10.1016/j.jflm.2026.103195. Epub 2026 Jun 21. PMID- 42330079 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260824 IS - 1940-087X (Electronic) IS - 1940-087X (Linking) IP - 232 DP - 2026 Jun 2 TI - Mental Health, Sleep, and Eating Patterns Among Saudi Adults During Ramadan Fasting - A Cross-Sectional Study. LID - 10.3791/70640 [doi] AB - Ramadan fasting involves marked shifts in sleep-wake cycles, dietary habits, and daily routines, all of which may influence psychological well-being. Although Ramadan represents a naturalistic model of structured, time-restricted fasting, limited research in Saudi Arabia has explored how sociodemographic factors shape mental health, sleep, and eating behaviors during this period. This study examined these outcomes in adults across multiple regions of the country. A descriptive cross-sectional survey was conducted in March 2025 among adults aged 18-60 years residing in Saudi Arabia who observed daytime fasting during Ramadan. A total of 464 participants were recruited through convenience sampling. Data were collected using a validated, culturally adapted questionnaire that assessed psychological well-being, sleep patterns, and eating behaviors. Analyses included descriptive statistics, chi-square tests, and multivariable logistic regression, with p < 0.05 as the significance threshold. Most respondents were female (56.5%) and aged 18-40 years (77.1%). Female sex was significantly associated with depressive feelings and reduced interest (p < 0.05) and independently predicted psychological distress (AOR = 1.35, 95% CI: 1.08-1.72). Adults aged 26-39 and 40-60 years showed higher odds of sleep disturbance and altered eating behaviors (p < 0.05). Participants from the Eastern region demonstrated elevated odds of psychological distress (AOR = 1.80), sleep disturbances (AOR = 2.05), and changes in eating patterns (AOR = 1.50). Employment status was associated with daytime fatigue and non-hunger-driven eating patterns. Ramadan-related lifestyle changes are associated with measurable variations in psychological well-being, sleep quality, and eating behavior. Women, middle-aged adults, and residents of the eastern region appeared to be more vulnerable to these effects. Tailored public health strategies promoting mental health, sleep hygiene, and healthy eating during altered daily routines may help mitigate these impacts. FAU - Albaik, Mai AU - Albaik M AD - Department of Chemistry, Preparatory Year Program, Batterjee Medical College; mai.albaik@bmc.edu.sa. FAU - Sulaiman, Sarah Ali AU - Sulaiman SA AD - General Medicine Practice Program, Batterjee Medical College. FAU - Alyamani, Shaza Abdullah AU - Alyamani SA AD - Department of Biology, Preparatory Year Program, Batterjee Medical College. FAU - Thalib, Husna Irfan AU - Thalib HI AD - General Medicine Practice Program, Batterjee Medical College. FAU - Tahir, Khadijah AU - Tahir K AD - General Medicine Practice Program, Batterjee Medical College. FAU - Hifni, Badriah Abdullah AU - Hifni BA AD - Department of Biology, Preparatory Year Program, Batterjee Medical College. LA - eng PT - Journal Article PT - Video-Audio Media DEP - 20260602 PL - United States TA - J Vis Exp JT - Journal of visualized experiments : JoVE JID - 101313252 SB - IM MH - Humans MH - Adult MH - Saudi Arabia MH - Cross-Sectional Studies MH - Female MH - Male MH - *Sleep/physiology MH - Young Adult MH - Middle Aged MH - *Feeding Behavior/physiology/psychology MH - Adolescent MH - *Fasting/psychology/physiology MH - *Mental Health MH - *Islam MH - Intermittent Fasting EDAT- 2026/06/22 19:01 MHDA- 2026/06/22 19:02 CRDT- 2026/06/22 14:04 PHST- 2026/06/22 19:02 [medline] PHST- 2026/06/22 19:01 [pubmed] PHST- 2026/06/22 14:04 [entrez] AID - 10.3791/70640 [doi] PST - epublish SO - J Vis Exp. 2026 Jun 2;(232). doi: 10.3791/70640. PMID- 42329961 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - Dietary supplement consumption among active individuals in Saudi Arabia. PG - e0351208 LID - 10.1371/journal.pone.0351208 [doi] LID - e0351208 AB - BACKGROUND: Despite the increasing use of dietary supplements in Saudi Arabia, accurate information on their consumption patterns and predictors is essential for effective policy planning. OBJECTIVE: This study aimed to estimate the prevalence of dietary supplement consumption, assess perceptions regarding their health effects, and identify demographic, health-related, and knowledge- and practice-based factors influencing their use among active individuals in Saudi Arabia. METHODS: This cross-sectional study identified predictors of dietary supplement consumption using a Likert-scale questionnaire adapted from validated local and international tools with minor modifications. Structural equation modeling was conducted by defining multiple sets of regression equations. The analyses were performed using R software (Version 4.1.2) with the lavaan and semPlot packages. A two-tailed p-value < 0.05 was considered statistically significant. RESULTS: A total of 3,800 active individuals from 13 Saudi Arabian regions participated in this study. The prevalence of dietary supplement use among active individuals was 63.82%. Health characteristics and knowledge and practice domains showed a highly significant influence on supplement consumption, whereas the demographic domain did not show a significant association in the structural equation model, although several demographic variables were significantly associated with supplement use in bivariate analysis. CONCLUSION: The prevalence of dietary supplement use among physically active individuals in Saudi Arabia exceeded the prevalence rates reported in several international populations, with more than three out of every five participants indicating use of dietary supplements. CI - Copyright: (c) 2026 Alsayegh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Alsayegh, Abdulrahman A AU - Alsayegh AA AUID- ORCID: 0000-0001-6948-4582 AD - Department of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia. FAU - Alzaben, Abeer S AU - Alzaben AS AUID- ORCID: 0000-0001-9813-1524 AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Abu Haddash, Yahya M AU - Abu Haddash YM AD - Department of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia. FAU - Busayli, Abdulrahman M AU - Busayli AM AD - Department of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia. FAU - Chandika, Rama M AU - Chandika RM AD - Department of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, Jazan, Saudi Arabia. FAU - Alsuhaibani, Munirah N AU - Alsuhaibani MN AD - Saudi Food and Drug Authority, Riyadh, Kingdom of Saudi Arabia. FAU - Albishi, Sara A AU - Albishi SA AUID- ORCID: 0009-0001-7930-2743 AD - Clinical Nutrition Department, College of Applied Medical Sciences, University of Hafr Al Batin, Hafr Al-Batin, Saudi Arabia. FAU - Hanbazaza, Mahitab A AU - Hanbazaza MA AD - Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Abuzaid, Omar I AU - Abuzaid OI AD - Department of Clinical Nutrition, College of Applied Medical Sciences, Imam Abdulrahman bin Faisal University, Dammam, Kingdom of Saudi Arabia. FAU - Alkhalaf, Majed M AU - Alkhalaf MM AD - Executive Directorate of Public Health Policies and Regulations at Saudi Public Health Authority, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260622 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Cross-Sectional Studies MH - *Dietary Supplements/statistics & numerical data MH - Saudi Arabia MH - *Health Knowledge, Attitudes, Practice MH - Surveys and Questionnaires/statistics & numerical data MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - *Exercise/statistics & numerical data PMC - PMC13286177 COIS- The authors have declared that no competing interests exist. EDAT- 2026/06/22 19:00 MHDA- 2026/06/22 19:01 PMCR- 2026/06/22 CRDT- 2026/06/22 13:42 PHST- 2025/05/24 00:00 [received] PHST- 2026/05/24 00:00 [accepted] PHST- 2026/06/22 19:01 [medline] PHST- 2026/06/22 19:00 [pubmed] PHST- 2026/06/22 13:42 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - PONE-D-25-22005 [pii] AID - 10.1371/journal.pone.0351208 [doi] PST - epublish SO - PLoS One. 2026 Jun 22;21(6):e0351208. doi: 10.1371/journal.pone.0351208. eCollection 2026. PMID- 42329656 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260908 IS - 2168-6211 (Electronic) IS - 2168-6203 (Print) IS - 2168-6203 (Linking) VI - 180 IP - 9 DP - 2026 Sep 1 TI - Obesity Management Pharmacotherapies and Lifestyle Treatment for Pediatric Obesity Management: A Systematic Review and Network Meta-Analysis. PG - 961-974 LID - 10.1001/jamapediatrics.2026.2248 [doi] AB - IMPORTANCE: Pediatric obesity is a global health challenge. Although health behavior and lifestyle treatment (HBLT) is foundational, the comparative effectiveness of HBLT, various pharmacotherapies, and their combinations remains unclear. OBJECTIVE: To compare the effectiveness of obesity management pharmacotherapies, structured lifestyle treatment, and their combinations on weight management outcomes in children and adolescents living with obesity. DATA SOURCES: A systematic search was conducted in 4 electronic databases (Embase, CENTRAL, PsycINFO, and PubMed) from inception to June 17, 2025. DATA SELECTION: Randomized clinical trials (RCTs) involving children and adolescents (aged 10-19 years) with obesity were selected. Interventions included lifestyle treatment (HBLT and counseling), obesity management pharmacotherapies (glucagon-like peptide-1 receptor agonists, metformin, orlistat, phentermine topiramate), or their combination vs control. DATA EXTRACTION AND SYNTHESIS: Data were extracted and validity assessed according to PRISMA guidelines. A random-effects network meta-analysis was used to pool data. Meta-regression was used to explore outcome moderators. MAIN OUTCOMES AND MEASURES: Primary outcomes were body mass index (BMI; calculated as weight in kilograms divided by height in meters squared) and BMI z score; secondary outcomes included waist circumference (WC), fat mass (FM), and lean mass (LM). RESULTS: A total of 42 RCTs with 3835 participants (median [IQR] age, 14.5 [13.3-15.1] years; 2270 female [59.2%]) were included. Treatments combining pharmacotherapy and lifestyle treatment demonstrated the greatest efficacy across all adiposity-related outcomes. Semaglutide plus counseling was associated with the largest BMI reduction (mean difference, -8.31; 95% CI, -12.33 to -4.28) and BMI z score reduction (mean difference, -1.80; 95% CI, -2.39 to -1.21), although this estimate was based on a limited number of studies. All pharmacological treatments were more effective when paired with lifestyle treatment, associated with significantly greater BMI and BMI z score reductions than the same medications alone. Based on the primary analysis, HBLT as monotherapy was associated with substantial decreases in BMI (mean difference, -3.85; 95% CI, -4.91 to -2.80) and BMI z score (mean difference, -0.89; 95% CI, -1.17 to -0.61) vs control. CONCLUSIONS AND RELEVANCE: Finding of this systematic review and network meta-analysis suggest that combining lifestyle treatment with obesity management medications was associated with the greatest short-term (typically 6 to 12 months) weight reduction in adolescents with obesity. HBLT remained an indispensable component of any effective weight management, delivering meaningful weight loss and healthier body composition on its own. Combined with lifestyle treatment, pharmacotherapy was a key component, not solely an adjunct, associated with the greatest BMI and BMI z score improvements, and long-term sustainability and safety were monitored. FAU - Wan, Ke-Wen AU - Wan KW AD - Academy of Wellness and Human Development, Faculty of Arts and Social Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. AD - Dr Stephen Hui Research Centre for Physical Recreation and Wellness, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. FAU - Lei, Evander Fung-Chau AU - Lei EF AD - Academy of Wellness and Human Development, Faculty of Arts and Social Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. AD - Dr Stephen Hui Research Centre for Physical Recreation and Wellness, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. FAU - Liu, Ying AU - Liu Y AD - Academy of Wellness and Human Development, Faculty of Arts and Social Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. FAU - Taddese, Asefa Adimasu AU - Taddese AA AD - Academy of Wellness and Human Development, Faculty of Arts and Social Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. FAU - Ip, Patrick AU - Ip P AD - Department of Paediatrics and Adolescent Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. FAU - Torbahn, Gabriel AU - Torbahn G AD - Department of Pediatrics, Paracelsus Medical University, Klinikum Nurnberg, Universitatsklinik der Paracelsus Medizinischen Privatuniversitat Nurnberg, Nuremberg, Germany. AD - Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria. AD - Obesity research unit, Paracelsus Medical University, Salzburg, Austria. FAU - Weghuber, Daniel AU - Weghuber D AD - Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria. AD - Obesity research unit, Paracelsus Medical University, Salzburg, Austria. FAU - Huang, Wendy Y AU - Huang WY AD - Academy of Wellness and Human Development, Faculty of Arts and Social Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. AD - Dr Stephen Hui Research Centre for Physical Recreation and Wellness, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. FAU - Tam, Bjorn T AU - Tam BT AD - Academy of Wellness and Human Development, Faculty of Arts and Social Sciences, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. AD - Dr Stephen Hui Research Centre for Physical Recreation and Wellness, Hong Kong Baptist University, Kowloon Tong, Hong Kong SAR, China. LA - eng PT - Journal Article PT - Network Meta-Analysis PT - Systematic Review PL - United States TA - JAMA Pediatr JT - JAMA pediatrics JID - 101589544 RN - 0 (Anti-Obesity Agents) RN - 9100L32L2N (Metformin) RN - 53AXN4NNHX (Semaglutide) SB - IM MH - Humans MH - Child MH - *Pediatric Obesity/therapy/drug therapy MH - Adolescent MH - *Anti-Obesity Agents/therapeutic use MH - *Life Style MH - *Obesity Management/methods MH - Combined Modality Therapy MH - Body Mass Index MH - Metformin/therapeutic use MH - Semaglutide PMC - PMC13288192 COIS- Conflict of Interest Disclosures: Dr Torbahn reported having a board membership of the Working Group Obesity in Childhood and Adolescence of the German Association for the Study of Obesity; being a co-opted board member of the European Childhood Obesity Group; and receiving travel grants or reimbursements from the European Association for the Study of Obesity, the German Association for the Study of Obesity, and the European Childhood Obesity Group outside the submitted work. Dr Weghuber reported receiving consulting fees from Novo Nordisk, Eli Lilly, and Rhythm Pharmaceuticals outside the submitted work. No other disclosures were reported. EDAT- 2026/06/22 13:42 MHDA- 2026/09/08 17:36 PMCR- 2027/06/22 CRDT- 2026/06/22 11:33 PHST- 2026/09/08 17:36 [medline] PHST- 2026/06/22 13:42 [pubmed] PHST- 2026/06/22 11:33 [entrez] PHST- 2027/06/22 00:00 [pmc-release] AID - 2850145 [pii] AID - poi260032 [pii] AID - 10.1001/jamapediatrics.2026.2248 [doi] PST - ppublish SO - JAMA Pediatr. 2026 Sep 1;180(9):961-974. doi: 10.1001/jamapediatrics.2026.2248. PMID- 42329506 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260813 IS - 1573-7365 (Electronic) IS - 0885-7490 (Print) IS - 0885-7490 (Linking) VI - 41 IP - 1 DP - 2026 Jun 22 TI - Treatment strategies, radiological recovery, and neurodevelopmental outcomes in paediatric Maple Syrup Urine Disease: a 20-year single-centre experience from Turkiye. LID - 10.1007/s11011-026-01896-8 [doi] LID - 140 AB - Maple Syrup Urine Disease (MSUD) is a rare autosomal recessive metabolic disorder characterised by defective branched-chain amino acid (BCAA) catabolism, leading to neurotoxicity, recurrent metabolic crises, and neurodevelopmental impairment. Evidence on long-term outcomes in paediatric cohorts, particularly with pharmacological adjuncts such as sodium phenylbutyrate (NaPBA) and radiological recovery, remains limited. We undertook a retrospective review of 13 paediatric patients with MSUD (69.2% classic phenotype, 30.8% intermittent) followed at a tertiary metabolic centre in Turkiye between 2003 and 2022. Demographic, biochemical, neurodevelopmental, neuroimaging, and genetic data were evaluated, with specific attention to dietary management, haemodialysis during acute decompensation, and NaPBA therapy. All patients exhibited neurodevelopmental delay, which was more pronounced in the classic phenotype. Milestone-level analysis demonstrated delays in walking (85%), sentence formation (92.3%), and toilet training (92.3%). One year after dietary intervention, mean plasma concentrations of leucine, isoleucine, and valine decreased by 60.9%, 55.9%, and 65.0%, respectively (p < 0.01). Haemodialysis during metabolic crises rapidly reduced leucine (- 73.8%) and ammonia (- 66%), though was more frequently required in patients with the classic phenotype. NaPBA treatment was associated with lower leucine levels during follow-up (p < 0.05). Baseline MRI abnormalities were identified in 87% of patients; 57% showed complete resolution post-treatment, with partial radiological improvement observed alongside clinical follow-up. A phenotype-specific approach combining early dietary intervention, timely haemodialysis in acute crises, and selective use of NaPBA may support metabolic stabilisation and radiological improvement in selected patients. Larger multicentre studies are warranted to validate these findings and refine management protocols. CI - (c) 2026. The Author(s). FAU - Uylas, Kemal AU - Uylas K AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Yazici, Havva AU - Yazici H AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Altinok, Yasemin Atik AU - Altinok YA AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Celik, Merve Yoldas AU - Celik MY AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Karapinar, Fehime Erdem AU - Karapinar FE AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Ozkaya, Pinar Yazici AU - Ozkaya PY AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Isik, Esra AU - Isik E AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Eraslan, Cenk AU - Eraslan C AD - Department of Radiology, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Canda, Ebru AU - Canda E AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Cogulu, Ozgur AU - Cogulu O AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Karapinar, Bulent AU - Karapinar B AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Habif, Sara AU - Habif S AD - Department of Biochemistry, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Coker, Mahmut AU - Coker M AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. FAU - Ucar, Sema Kalkan AU - Ucar SK AD - Department of Pediatrics, Ege University Medical Faculty, Bornova, Izmir, Turkiye. semakalkan@hotmail.com. LA - eng PT - Journal Article DEP - 20260622 PL - United States TA - Metab Brain Dis JT - Metabolic brain disease JID - 8610370 RN - 0 (Phenylbutyrates) RN - GMW67QNF9C (Leucine) SB - IM MH - Humans MH - *Maple Syrup Urine Disease/diagnostic imaging/therapy/blood MH - Female MH - Retrospective Studies MH - Male MH - Treatment Outcome MH - Infant MH - Child, Preschool MH - Phenylbutyrates/therapeutic use MH - Magnetic Resonance Imaging MH - Child MH - Leucine/blood PMC - PMC13287102 OTO - NOTNLM OT - Branched-chain amino acids OT - Haemodialysis OT - MRI OT - Maple syrup urine disease OT - Neurodevelopment OT - Sodium phenylbutyrate COIS- Declarations. Ethical declarations: The study protocol was approved by the Ege University Medical Research Ethics Committee (approval date: 09.09.2022, decision number: 22-9 T/30) and was conducted in accordance with the principles of the Declaration of Helsinki. Competing interests: The authors declare no competing interests. EDAT- 2026/06/22 13:43 MHDA- 2026/06/22 19:12 PMCR- 2026/06/22 CRDT- 2026/06/22 11:17 PHST- 2026/01/07 00:00 [received] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/06/22 19:12 [medline] PHST- 2026/06/22 13:43 [pubmed] PHST- 2026/06/22 11:17 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1007/s11011-026-01896-8 [pii] AID - 1896 [pii] AID - 10.1007/s11011-026-01896-8 [doi] PST - epublish SO - Metab Brain Dis. 2026 Jun 22;41(1):140. doi: 10.1007/s11011-026-01896-8. PMID- 42329372 OWN - NLM STAT- MEDLINE DCOM- 20261025 LR - 20261028 IS - 1435-165X (Electronic) IS - 1018-8827 (Print) IS - 1018-8827 (Linking) VI - 35 IP - 10 DP - 2026 Oct TI - The weight concerns scale in Australian adolescents: Factor structure, gender invariance, and screening utility. PG - 3313-3323 LID - 10.1007/s00787-026-03101-8 [doi] AB - Despite the increased incidence of disordered eating among adolescents and low help-seeking rates, there is currently a lack of evidence supporting use of screening tools for this population. The present study aimed to address this gap by examining the factor structure, gender invariance, and psychological correlates of the Weight Concerns Scale (WCS) in a large sample of Australian adolescents to evaluate its potential suitability as a screening tool. Participants (n = 1022) aged 12-17 (M(age) = 14.73; SD = 1.55) were recruited from five public secondary schools in South Australia between May and August 2023. All participants completed the WCS and psychological measures of life satisfaction, resilience, psychological distress, self-injurious thoughts and behaviours. Confirmatory factor analysis replicated the original one-factor structure: chi(2)(5) = 44.83, p < .001, RMSEA = 0.09, CFI = 0.99. Measurement non-invariance was found by gender and socio-economic-status, suggesting the scale functions differently across these subgroups. A cut-off score of >/= 47 on WCS was associated with elevated psychological distress across all groups except for boys from lower socio-economic-status backgrounds. The present study is the first to apply confirmatory factor analysis to the WCS in adolescents. Future research needs to establish validity of the WCS as a screen in adolescents in terms of associations with ED psychopathology and behaviours. In addition, validation against diagnostic interview is crucial to establishing the WCS as a screening tool. CI - (c) 2026. The Author(s). FAU - Radunz, Marcela AU - Radunz M AUID- ORCID: 0000-0002-2858-0313 AD - Discipline of Psychology, Flinders University, GPO Box 2100, Adelaide, South Australia, 5001, Australia. marcela.radunz@flinders.edu.au. FAU - Jabs, Maya AU - Jabs M AUID- ORCID: 0009-0000-8369-1086 AD - Discipline of Psychology, Flinders University, GPO Box 2100, Adelaide, South Australia, 5001, Australia. FAU - King, Daniel L AU - King DL AUID- ORCID: 0000-0002-1762-2581 AD - Discipline of Psychology, Flinders University, GPO Box 2100, Adelaide, South Australia, 5001, Australia. FAU - Wade, Tracey D AU - Wade TD AUID- ORCID: 0000-0003-4402-770X AD - Discipline of Psychology, Flinders University, GPO Box 2100, Adelaide, South Australia, 5001, Australia. LA - eng PT - Journal Article DEP - 20260622 PL - Germany TA - Eur Child Adolesc Psychiatry JT - European child & adolescent psychiatry JID - 9212296 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Factor Analysis, Statistical MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Psychometrics MH - Child MH - Sex Factors MH - Australia MH - *Psychiatric Status Rating Scales/standards MH - Surveys and Questionnaires MH - South Australia MH - Mass Screening MH - *Body Weight MH - Psychological Distress PMC - PMC13696600 OTO - NOTNLM OT - Adolescents OT - Eating disorders OT - Factor structure OT - Screening tool OT - Weight concerns COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/06/22 13:44 MHDA- 2026/10/25 17:31 PMCR- 2026/06/22 CRDT- 2026/06/22 11:13 PHST- 2025/05/07 00:00 [received] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/10/25 17:31 [medline] PHST- 2026/06/22 13:44 [pubmed] PHST- 2026/06/22 11:13 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1007/s00787-026-03101-8 [pii] AID - 3101 [pii] AID - 10.1007/s00787-026-03101-8 [doi] PST - ppublish SO - Eur Child Adolesc Psychiatry. 2026 Oct;35(10):3313-3323. doi: 10.1007/s00787-026-03101-8. Epub 2026 Jun 22. PMID- 42328216 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260622 LR - 20260813 IS - 0974-7052 (Print) IS - 0975-1904 (Electronic) IS - 0974-7052 (Linking) VI - 19 IP - 3 DP - 2026 Mar TI - Association Between Junk Food Consumption and Behavioral Outcomes in 10-15-year-old Children: A Cross-sectional Questionnaire-based Study. PG - 318-323 LID - 10.5005/jp-journals-10005-3474 [doi] AB - BACKGROUND: Dietary habits and food consumption patterns have long been a focus of interest for both researchers and healthcare professionals. In recent years, growing awareness of the role of nutrition in overall well-being, along with a noticeable rise in diet-related health problems, has intensified this focus. Furthermore, increased concern is surfacing regarding the effect of junk food has on the behavior patterns among children; however, there is limited evidence. The present questionnaire study aims to investigate the association between junk food consumption and behavioral issues among 10-15-year-old children attending schools in and around Rajanagaram, Andhra Pradesh. METHODS: A cross-sectional study was conducted among 1,500 students using a validated dietary questionnaire and the Strengths and Difficulties Questionnaire (SDQ) adolescent self-report version. Junk food consumption (based on IAP guidelines) and behavioral categories were evaluated from the reported questionnaires, and the association between the two variables was analyzed statistically using Chi-square and Pearson correlation tests. RESULTS: Moderate junk food consumption was reported by 71.3% of children, with 11.8% reporting severe intake. SDQ revealed 81.6% had abnormal behavior scores, predominantly hyperactivity (54.78%) and conduct problems (67.02%). Although Pearson correlation was statistically nonsignificant (p = 0.963), a trend of increased behavioral issues with higher junk food intake was observed. CONCLUSION: A high prevalence of behavioral disturbances was seen among children with moderate to severe junk food consumption. Educational and policy-based interventions focusing on nutrition are urgently needed. HOW TO CITE THIS ARTICLE: Markapurapu BS, Balakrishnan V, Martha S, et al. Association Between Junk Food Consumption and Behavioral Outcomes in 10-15-year-old Children: A Cross-sectional Questionnaire-based Study. Int J Clin Pediatr Dent 2026;19(3):318-323. CI - Copyright (c) 2026; The Authors. FAU - Markapurapu, Baba S AU - Markapurapu BS AUID- ORCID: 0009-0000-0031-1202 AD - Department of Pediatric and Preventive Dentistry, Dr NTR University of Health Sciences, Vijayawada, Andhra Pradesh, India. FAU - Balakrishnan, Veena AU - Balakrishnan V AUID- ORCID: 0009-0009-1469-6559 AD - Department of Pedodontics and Preventive Dentistry, Lenora Institute of Dental Sciences, Rajamahendravaram, Andhra Pradesh, India. FAU - Martha, Satyam AU - Martha S AUID- ORCID: 0000-0003-4739-3000 AD - Department of Pedodontics and Preventive Dentistry, Lenora Institute of Dental Sciences, Rajamahendravaram, Andhra Pradesh, India. FAU - Maganti, Sri R AU - Maganti SR AD - Department of Pedodontics and Preventive Dentistry, Lenora Institute of Dental Sciences, Rajamahendravaram, Andhra Pradesh, India. FAU - Haritha, K AU - Haritha K AUID- ORCID: 0000-0003-3968-9987 AD - Department of Pedodontics and Preventive Dentistry, Lenora Institute of Dental Sciences, Rajamahendravaram, Andhra Pradesh, India. FAU - Yaramala, Harshitha AU - Yaramala H AUID- ORCID: 0009-0002-3172-2092 AD - Department of Pedodontics and Preventive Dentistry, Lenora Institute of Dental Sciences, Rajamahendravaram, Andhra Pradesh, India. LA - eng PT - Journal Article DEP - 20260302 PL - India TA - Int J Clin Pediatr Dent JT - International journal of clinical pediatric dentistry JID - 101585405 PMC - PMC13280508 OTO - NOTNLM OT - Adolescent behavior OT - Cross-sectional study OT - Junk food OT - Schoolchildren OT - Strengths and Difficulties Questionnaire COIS- Source of support: Nil Conflict of interest: NoneConflict of interest: None EDAT- 2026/06/22 13:43 MHDA- 2026/06/22 13:44 PMCR- 2026/04/01 CRDT- 2026/06/22 07:23 PHST- 2025/06/21 00:00 [received] PHST- 2025/07/21 00:00 [accepted] PHST- 2026/06/22 13:44 [medline] PHST- 2026/06/22 13:43 [pubmed] PHST- 2026/06/22 07:23 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - 10.5005/jp-journals-10005-3474 [doi] PST - ppublish SO - Int J Clin Pediatr Dent. 2026 Mar;19(3):318-323. doi: 10.5005/jp-journals-10005-3474. Epub 2026 Mar 2. PMID- 42327899 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260622 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Recombinant human IGF-1 alleviates dyslipidemia induced by lactational maternal dietary restriction. PG - 1829936 LID - 10.3389/fped.2026.1829936 [doi] LID - 1829936 AB - BACKGROUND: Extrauterine growth restriction (EUGR) critically impacts preterm infants, often due to nutritional deficiency. Lactational protein restriction can disrupt offspring glucose/lipid metabolism by altering gene expression and increasing branched-chain amino acid catabolism. OBJECTIVE: This study aimed to investigate the effects of postpartum maternal dietary restriction (MDR) on growth and lipid metabolism in Sprague-Dawley (SD) rat offspring, and to explore the underlying mechanisms through Agilent microarray-based transcriptomic analysis. METHODS: An EUGR rat model was established by maternal dietary restriction. Body weight, body length, serum insulin-like growth factor-1 (IGF-1), and lipid profiles were monitored from postnatal day 1 to day 21. To evaluate therapeutic effects, a separate cohort of EUGR pups received recombinant human IGF-1 (rhIGF-1) or PBS. Liver transcriptomic analysis was conducted to identify differentially expressed genes. Based on transcriptomic results, lipoprotein lipase (LPL) was overexpressed in HepG2 cells for in vitro functional validation. RESULTS: At 3 weeks of age, EUGR pups showed significantly lower body weight and length than controls (p < 0.01). Serum triglycerides (TG) were reduced in EUGR rats (p < 0.05), whereas total cholesterol and HDL-C were elevated. rhIGF-1 treatment did not improve growth, but significantly reduced HDL-C compared with PBS. Liver transcriptomics revealed altered expression of lipid-metabolism genes in EUGR animals; notably, LPL expression was increased. In HepG2 cells, LPL overexpression significantly downregulated the lipogenic genes ACACA and SCD (p < 0.01). CONCLUSION: Maternal dietary restriction induces EUGR in rats, characterized by growth impairment and dyslipidemia. rhIGF-1 treatment failed to improve growth but modulated HDL-C levels. Liver transcriptomics in EUGR animals show upregulation of LPL, and in vitro experiments demonstrate that LPL can downregulate ACACA and SCD, suggesting that the LPL/ACACA/SCD pathway may underlie the observed triglyceride alterations in EUGR. CI - (c) 2026 Liu, Ma, Cui and Feng. FAU - Liu, Xin AU - Liu X AD - Department of Pediatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, China. AD - Neonatal Intensive Care Unit, Department of Pediatrics, Peking University First Hospital, Beijing, China. FAU - Ma, Yuanyuan AU - Ma Y AD - Laboratory of Animal Facility, Peking University First Hospital, Beijing, China. FAU - Cui, Hong AU - Cui H AD - Department of Pediatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, China. FAU - Feng, Qi AU - Feng Q AD - Neonatal Intensive Care Unit, Department of Pediatrics, Peking University First Hospital, Beijing, China. LA - eng PT - Journal Article DEP - 20260604 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13275451 OTO - NOTNLM OT - IGF-1 OT - extrauterine growth restriction OT - lactational dietary restriction OT - lipid metabolism OT - rat animal model COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/22 13:42 MHDA- 2026/06/22 13:43 PMCR- 2026/06/04 CRDT- 2026/06/22 07:20 PHST- 2026/03/13 00:00 [received] PHST- 2026/05/17 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/06/22 13:43 [medline] PHST- 2026/06/22 13:42 [pubmed] PHST- 2026/06/22 07:20 [entrez] PHST- 2026/06/04 00:00 [pmc-release] AID - 10.3389/fped.2026.1829936 [doi] PST - epublish SO - Front Pediatr. 2026 Jun 4;14:1829936. doi: 10.3389/fped.2026.1829936. eCollection 2026. PMID- 42327482 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260622 LR - 20260813 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 6 DP - 2026 Jun TI - Shear Wave Elastography in Children: Normative Values and the Impact of Healthy Habits in a Cross-Sectional Study. PG - e72653 LID - 10.1002/hsr2.72653 [doi] LID - e72653 AB - OBJECTIVES: Biomechanical properties of the musculoskeletal system are important to understand muscle function, but they are difficult to assess noninvasively. Shear wave elastography (SWE) allows objective quantification of muscle elasticity. However, normative data and the influence of lifestyle habits on muscle elasticity in children remain unclear, particularly across multiple upper and lower limb muscles and in relation to modifiable healthy behaviors. The main objective was to assess muscle elasticity at rest and during maximum passive stretching (MPS) in children using SWE, and to address existing gaps by evaluating multiple muscles from both limbs, as well as to evaluate the influence of lifestyle factors, with particular attention to healthy habits. DESIGN AND METHODS: SWE was used to measure the elasticity of the biceps brachii, pronator teres, adductor longus, lateral gastrocnemius, and soleus in 44 typically developing children (mean age 8.9 years; range 3-14 years; 27 females). Measurements were taken at rest and MPS. Data included anthropometry, physical fitness, Mediterranean diet adherence, moderate-to-vigorous physical activity (MVPA), and sleep duration, allowing the exploration of lifestyle-related determinants of muscle elasticity. RESULTS: Reliability estimates exceeded 0.91, indicating excellent consistency. SWE values increased with higher Mediterranean adherence during MPS in all muscles, while at rest, an inverse relationship appeared in biceps and pronator teres. Sleep time was negatively associated with SWE at rest and positively adductor longus during MPS. MVPA showed some associations without consistent patterns. CONCLUSIONS: SWE is a reliable and objective technique to evaluate muscle elasticity in typically developing children. By providing multi-muscle reference data from both upper and lower limbs and demonstrating associations with diet and sleep, this study extends current pediatric SWE literature beyond feasibility and reliability. These findings suggest that SWE could help quantify the physiological impact of healthy habits on muscle properties during childhood. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Casellas-Vidal, Dolors AU - Casellas-Vidal D AUID- ORCID: 0000-0001-9560-6758 AD - Servei de Pediatria Hospital Universitari Doctor Josep Trueta Girona Spain. AD - Neurodevelopmental Group [Girona Biomedical Research Institute]-IDIBGI Institute of Health Assistance (IAS), Parc Hospitalari Marti i Julia Girona Spain. FAU - Font-Llado, Raquel AU - Font-Llado R AD - University School of Health and Sport (EUSES) University of Girona Girona Spain. AD - Research Group of Culture and Education, Institute of Educational Research University of Girona Girona Spain. FAU - Osiniri, Ines AU - Osiniri I AD - Servei de Pediatria, Clinica Bofill Girona Spain. FAU - Camos-Carreras, Maria AU - Camos-Carreras M AD - Servei de Pediatria Hospital Universitari Doctor Josep Trueta Girona Spain. AD - Neurodevelopmental Group [Girona Biomedical Research Institute]-IDIBGI Institute of Health Assistance (IAS), Parc Hospitalari Marti i Julia Girona Spain. FAU - Ruiz-Eizmendi, Aintzane AU - Ruiz-Eizmendi A AD - Servei de Rehabilitacio Hospital Universitari Doctor Josep Trueta Girona Spain. FAU - Serrano-Ferrer, Juan AU - Serrano-Ferrer J AUID- ORCID: 0009-0001-6080-2772 AD - University School of Health and Sport (EUSES) University of Girona Girona Spain. FAU - Casellas, Joaquim AU - Casellas J AD - Departament de Ciencia Animal i dels Aliments Universitat Autonoma de Barcelona Bellaterra Spain. FAU - Lopez-Bermejo, Abel AU - Lopez-Bermejo A AD - Servei de Pediatria Hospital Universitari Doctor Josep Trueta Girona Spain. AD - Pediatric Endocrinology Group Girona Biomedical Research Institute (IDIBGI) Salt Spain. FAU - Prats-Puig, Anna AU - Prats-Puig A AUID- ORCID: 0000-0002-5253-3808 AD - Research Group of Health and Health Care, Nursing Department University of Girona Girona Spain. LA - eng PT - Journal Article DEP - 20260619 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13281414 OTO - NOTNLM OT - children OT - healthy habits OT - lifestyle factors OT - muscle elasticity OT - shear wave elastography COIS- The authors declare no conflicts of interest. EDAT- 2026/06/22 13:42 MHDA- 2026/06/22 13:43 PMCR- 2026/06/19 CRDT- 2026/06/22 07:15 PHST- 2025/11/13 00:00 [received] PHST- 2026/05/28 00:00 [revised] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/06/22 13:43 [medline] PHST- 2026/06/22 13:42 [pubmed] PHST- 2026/06/22 07:15 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - HSR272653 [pii] AID - 10.1002/hsr2.72653 [doi] PST - epublish SO - Health Sci Rep. 2026 Jun 19;9(6):e72653. doi: 10.1002/hsr2.72653. eCollection 2026 Jun. PMID- 42327477 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260622 LR - 20260813 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 6 DP - 2026 Jun TI - Psychometric Properties of the Participation Motivation Questionnaire Among Hungarian Female Students. PG - e72696 LID - 10.1002/hsr2.72696 [doi] LID - e72696 AB - BACKGROUND AND AIM: Based on the self-determination theory (SDT), this study primarily aimed to examine the reliability and validity of the Hungarian version of the Participation Motivation Questionnaire (PMQ) among 13-15-year-old female students, and secondarily to describe their motivational profiles and the relationships between motives and physical activity level. METHODS: Three hundred twenty-five female students (mean age = 14.07; SD = 0.87) from nine different schools-wealthy, moderate, and lower income- were randomly sampled from Budapest and its suburbs. Exploratory Factor Analysis was used with the maximum likelihood extraction method and varimax rotation. To establish construct validity, Confirmatory Factor Analysis was conducted. Internal consistency of the questionnaire and its subscales was assessed using Cronbach's alpha. RESULTS: A 27‑item, six-factor solution emerged, partially differing from the original eight-factor structure, and showed acceptable internal consistency (alpha = 0.73-0.84). Associations between motivational factors and sociodemographic characteristics (age, socioeconomic status, urban-rural residence) and physical activity level revealed significant effects of sociodemographic factors on motivation. Fitness emerged as the only motivational factor showing a strong, direct relationship with adolescents' physical activity level. In terms of SDT, intrinsic‑oriented, health‑ and mastery‑related reasons appeared more important than ego‑related and extrinsic reasons for encouraging female students to be physically active. Given the cross-sectional design and the urban-skewed sample, these subgroup findings should be interpreted with caution and considered as a means of generating hypotheses. CONCLUSION: In conclusion, the Hungarian version of the PMQ appears suitable for assessing participation motives among female students in school and sport-related settings and may support educators and practitioners in better understanding motivational patterns when planning and evaluating physical activity programmes. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Ghazvini, Narges AU - Ghazvini N AUID- ORCID: 0000-0001-7335-3948 AD - Doctoral School, Hungarian University of Sports Science Budapest Hungary. AD - Department of Pedagogy Hungarian University of Sports Science Budapest Hungary. FAU - Hamar, Pal AU - Hamar P AUID- ORCID: 0009-0008-8651-3013 AD - Department of Pedagogy Hungarian University of Sports Science Budapest Hungary. AD - Sapientia Hungarian University of Transylvania Sf. Gheorghe Romania. AD - Ludovika University of Public Service Budapest Hungary. FAU - Takacs, Johanna AU - Takacs J AUID- ORCID: 0000-0002-8709-8826 AD - Department of Social Sciences Semmelweis University Budapest Hungary. FAU - Petridis, Leonidas AU - Petridis L AUID- ORCID: 0000-0002-8534-7550 AD - Research Center for Sport Physiology Hungarian University of Sport Science Budapest Hungary. FAU - Soos, Istvan AU - Soos I AUID- ORCID: 0000-0002-5511-9477 AD - Department of Pedagogy Hungarian University of Sports Science Budapest Hungary. LA - eng PT - Journal Article DEP - 20260620 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13282752 OTO - NOTNLM OT - Hungarian female students OT - participation motivation questionnaire OT - physical activity OT - self-determination theory OT - sociodemographic factors COIS- The authors declare no conflicts of interest. EDAT- 2026/06/22 13:44 MHDA- 2026/06/22 13:45 PMCR- 2026/06/20 CRDT- 2026/06/22 07:15 PHST- 2025/11/18 00:00 [received] PHST- 2026/03/09 00:00 [revised] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/06/22 13:45 [medline] PHST- 2026/06/22 13:44 [pubmed] PHST- 2026/06/22 07:15 [entrez] PHST- 2026/06/20 00:00 [pmc-release] AID - HSR272696 [pii] AID - 10.1002/hsr2.72696 [doi] PST - epublish SO - Health Sci Rep. 2026 Jun 20;9(6):e72696. doi: 10.1002/hsr2.72696. eCollection 2026 Jun. PMID- 42326953 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Cross-cultural adaptation and validation of the health-promoting lifestyle profile II for Mongolian university students. PG - 1846655 LID - 10.3389/fpubh.2026.1846655 [doi] LID - 1846655 AB - BACKGROUND: University lifestyle can have lasting effects on students' health, yet culturally validated instruments to examine health-promoting lifestyles are lacking in Mongolia. This study aimed to adapt the Health-Promoting Lifestyle Profile II (HPLP-II) and to assess the validity and reliability of its Mongolian version among students in Ulaanbaatar. METHODS: A cross-sectional study was conducted with 827 undergraduate students from three universities in Ulaanbaatar, Mongolia. The instrument was translated from English into Mongolian using standard forward- and backward-translation procedures. The final version retained six dimensions and 51 items. Construct validity was assessed using confirmatory factor analysis for a six-component structure, and internal consistency was evaluated using Cronbach's alpha and McDonald's omega. FINDINGS: Confirmatory factor analysis indicated a good fit for the six-factor structure (chi (2) = 14233.03; df = 1,275; p < 0.001; CFI = 0.95, GFI = 0.95, TLI = 0.95, SRMR = 0.065, and RMSEA = 0.031). The overall HPLP-II demonstrated high internal consistency (omega = 0.92, alpha = 0.91). However, the nutrition dimension exhibited the lowest reliability and factor loadings, suggesting revision for future studies. CONCLUSION: The Mongolian version of the HPLP-II demonstrated acceptable reliability and construct validity, supporting the use of a six-dimensional, 51-item instrument to assess health-promoting lifestyles among Mongolian university students. These findings provide a foundation for future health-promotion interventions in Mongolian university settings. CI - Copyright (c) 2026 Uitumen and Tarko. FAU - Uitumen, Erdenezul AU - Uitumen E AD - Doctoral School of Education, Faculty of Humanities and Social Sciences, University of Szeged, Szeged, Hungary. AD - Department of Nutrition, School of Public Health, Mongolian National University of Medical Sciences, Ulaanbaatar, Mongolia. FAU - Tarko, Klara AU - Tarko K AD - Juhasz Gyula Faculty of Education, Institute of Applied Health Sciences and Environmental Education, University of Szeged, Szeged, Hungary. LA - eng PT - Journal Article PT - Validation Study DEP - 20260605 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Students/statistics & numerical data/psychology MH - Universities MH - Mongolia MH - Female MH - Cross-Sectional Studies MH - Reproducibility of Results MH - Male MH - Young Adult MH - Surveys and Questionnaires/standards MH - *Health Promotion MH - *Healthy Lifestyle MH - *Cross-Cultural Comparison MH - Adult MH - *Life Style MH - Psychometrics MH - Adolescent PMC - PMC13279628 OTO - NOTNLM OT - Mongolia OT - health-promoting lifestyle OT - reliability OT - university students OT - validation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/22 13:43 MHDA- 2026/06/22 13:44 PMCR- 2026/06/05 CRDT- 2026/06/22 07:09 PHST- 2026/04/03 00:00 [received] PHST- 2026/05/12 00:00 [revised] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/22 13:44 [medline] PHST- 2026/06/22 13:43 [pubmed] PHST- 2026/06/22 07:09 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1846655 [doi] PST - epublish SO - Front Public Health. 2026 Jun 5;14:1846655. doi: 10.3389/fpubh.2026.1846655. eCollection 2026. PMID- 42326162 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260622 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 5 DP - 2026 May TI - A Retrospective Comparison of Transcutaneous and End-Tidal Carbon Dioxide Monitoring in Pediatric Polysomnography. PG - e109308 LID - 10.7759/cureus.109308 [doi] LID - e109308 AB - Background Accurate monitoring of carbon dioxide (CO(2)) is important in pediatric polysomnography (PSG), particularly for identifying nocturnal hypoventilation, a condition with significant clinical consequences in children, especially those with neuromuscular or pulmonary disorders. Two primary modalities are available for non-invasive CO(2) estimation: end-tidal CO(2) (EtCO(2)) and transcutaneous CO(2) (TcCO(2)). While both are widely used, their diagnostic equivalence remains unclear. This study aimed to address the clinical question of whether TcCO(2) and EtCO(2) measurements in pediatric PSG can replace each other. Methods A single-center retrospective study was conducted by including pediatric patients who underwent PSG with concurrent EtCO(2) and TcCO(2) monitoring. For each patient, mean, maximum, and minimum CO(2) values, as well as sleep duration with values exceeding 50 mmHg, were extracted and analyzed between the two modalities. The diagnostic rates of nocturnal hypoventilation as defined by the American Academy of Sleep Medicine (AASM) Manual were also compared. Results Among 127 children (median age 11 years, interquartile range age eight to 14), based on the Bland-Altman analysis, a positive mean bias was observed in all three comparisons, suggesting that EtCO(2) measurements were systematically lower than TcCO(2). Wide 95% limits of agreement in all TcCO(2) and EtCO(2) measurements were observed. A weakly positive correlation but with marginal statistical significance was noted between mean TcCO(2) and EtCO(2) values (rs=0.173, p=0.052). Maximum TcCO(2) and EtCO(2) values were also only weakly correlated (rs=0.288, p=0.001). The median of mean TcCO(2) was significantly higher than that of mean EtCO(2): 42.95 mmHg vs. 39.00 mmHg, respectively (Z = -8.06, p < 0.001). The median of maximum TcCO(2) was also significantly higher than that of maximum EtCO(2) values: 47.40 mmHg vs. 44.00 mmHg, respectively (Z = -7.50, p < 0.001). However, no statistically significant difference was observed for the corresponding minimum values (36.60 mmHg vs. 35.00 mmHg; Z = -1.94, p = 0.052). Ten out of 127 (7.9%) patients were diagnosed with hypoventilation by TcCO(2) measurement, none of whom could be diagnosed based on EtCO(2) measurement. Subgroup analysis by age, sex, obstructive sleep apnea (OSA) severity, obesity, craniofacial abnormalities, tonsillar hypertrophy, and syndromic diagnosis yielded no significantly different findings. Conclusions Our study suggested that EtCO(2) and TcCO(2) measurements in pediatric PSG may not be interchangeable, given the observed suboptimal agreement between the two modalities, i.e., the tendency for TcCO(2) values to be higher than EtCO(2), and the weak and mostly statistically insignificant correlation observed for CO(2) measurements. However, in the absence of arterial blood gas (ABG) as a reference standard, it was not possible to determine which modality more accurately reflects true arterial CO(2) levels or was more reliable for identifying nocturnal hypoventilation. CI - Copyright (c) 2026, Tsui et al. FAU - Tsui, Tak Kong AU - Tsui TK AD - Pediatrics, Pamela Youde Nethersole Eastern Hospital, Hong Kong, CHN. LA - eng PT - Journal Article DEP - 20260520 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13282146 OTO - NOTNLM OT - end-tidal co2 monitoring OT - nocturnal hypoventilation OT - obstructive sleep apnoea OT - paedatrics OT - polysomnography OT - trancutaneous co2 monitoring COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Hospital Authority Central Institutional Review Board issued approval PAED-2026-024. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/06/22 13:43 MHDA- 2026/06/22 13:44 PMCR- 2026/05/20 CRDT- 2026/06/22 07:03 PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/22 13:44 [medline] PHST- 2026/06/22 13:43 [pubmed] PHST- 2026/06/22 07:03 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - 10.7759/cureus.109308 [doi] PST - epublish SO - Cureus. 2026 May 20;18(5):e109308. doi: 10.7759/cureus.109308. eCollection 2026 May. PMID- 42325832 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260813 IS - 3006-6514 (Electronic) IS - 3006-6506 (Print) IS - 3006-6506 (Linking) VI - 3 IP - 2 DP - 2026 TI - Harnessing Artificial Intelligence for Hypothesis Generation in Childhood Asthma: Insights from NHANES. LID - 10003 [pii] LID - 10.70322/jrbtm.2026.10003 [doi] AB - Although large language models (LLMs) have undergone substantial development, their applicability to epidemiological research has not been sufficiently examined. This study aims to develop and evaluate an LLM-based framework for hypothesis generation and testing, demonstrating its application in childhood asthma in the National Health and Nutrition Examination Survey (NHANES). Pilot study was conducted to explore factors associated with childhood asthma in the 2001-2020 NHANES cycles. A modular agent system was developed, including Database Query, Statistic, Paper Search, and Paper Download tools, along with two LLM models (Key Generator and Hypothesis Tester). Multivariable logistic regression was used to test for the association between each variable and current asthma, generating a tentative affirmative claim. The Key Generator module produced keywords for literature search, the Paper Search and Paper Download tools queried PubMed and retrieved relevant studies, and the Hypothesis Tester module synthesized evidence and determined the support for claims for each variable. Keywords and conclusions were reviewed by researchers and validated using multiple LLMs (ChatGPT, DeepSeek, and Gemini) to ensure consistency and robustness. 25,839 children with (n = 2928) and without (n = 22,911) current asthma, and 10,359 variables were included in the multivariable analysis, which yielded 100 variables associated with asthma. Of these, 21 were directly related to asthma (supporting published studies), 43 were indirectly related to asthma (based on background knowledge, though not explicitly discussed in the available publications), and 34 were unrelated to asthma. Two variables were excluded due to a lack of discriminative keywords. This study demonstrates the effectiveness of LLM-based models for generating and testing hypotheses about childhood asthma. FAU - Liu, Jing AU - Liu J AD - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA. FAU - Han, Yueh-Ying AU - Han YY AD - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA. FAU - Ye, Xiangyu AU - Ye X AD - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA. FAU - Rosser, Franziska J AU - Rosser FJ AD - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA. FAU - Gaietto, Kristina M AU - Gaietto KM AD - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA. FAU - Zhao, Chongyue AU - Zhao C AD - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA. FAU - Chen, Wei AU - Chen W AD - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA. AD - Department of Biostatistics and Health Data Science, School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. FAU - Celedon, Juan C AU - Celedon JC AD - Division of Pediatric Pulmonary Medicine, UPMC Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA 15224, USA. LA - eng GR - R01 HL152475/HL/NHLBI NIH HHS/United States GR - R01 HL168539/HL/NHLBI NIH HHS/United States GR - T32 HL129949/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260428 PL - China TA - J Respir Biol Transl Med JT - Journal of respiratory biology and translational medicine JID - 9918786787606676 PMC - PMC13278482 MID - NIHMS2180431 OTO - NOTNLM OT - Artificial intelligence OT - Asthma OT - Children OT - Risk factors COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/22 13:43 MHDA- 2026/06/22 13:44 PMCR- 2026/06/19 CRDT- 2026/06/22 07:00 PHST- 2026/06/22 13:44 [medline] PHST- 2026/06/22 13:43 [pubmed] PHST- 2026/06/22 07:00 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10003 [pii] AID - 10.70322/jrbtm.2026.10003 [doi] PST - ppublish SO - J Respir Biol Transl Med. 2026;3(2):10003. doi: 10.70322/jrbtm.2026.10003. Epub 2026 Apr 28. PMID- 42325730 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260813 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 15 DP - 2026 TI - Dietary assessment tools for children and adolescents in Latin America: a scoping review. PG - e46 LID - 10.1017/jns.2026.10116 [doi] LID - e46 AB - Accurately assessing dietary intake in children and adolescents is essential for understanding dietary patterns and informing public health strategies. In Latin America, rapid nutrition transitions and increasing childhood obesity highlight the need for culturally appropriate, validated dietary assessment tools (DATs). However, methodological challenges and limited regional data hinder effective dietary surveillance. This scoping review identified and characterised DATs used among children and adolescents (5-18 years) in Latin America, examining tool types, features, validation and regional coverage. Following Joanna Briggs Institute and PRISMA-ScR guidelines, comprehensive searches were conducted in EMBASE, Web of Science, PubMed, and LILACS (April 2024) in English, Spanish, and Portuguese. Eligible studies included original research developing, validating, or applying DATs in Latin American populations. Of 13,946 records screened, 105 reports met the inclusion criteria. Brazil and Mexico contributed the most studies, while six countries (Paraguay, El Salvador, Nicaragua, Panama, Honduras, and Belize) had none. Forty-three DATs were identified, 77% of which were food frequency questionnaires (FFQs). Half targeted adolescents, 39% children, and 11% both groups. Most were interviewer-administered (58%) and applied in person (49%), with only 19% conducted online, reflecting regional digital limitations. Validation was reported for 70% of tools, primarily against 24 HR. The DAT landscape in Latin America remains dominated by FFQs and traditional administration methods, with limited use of digital platforms. Developing age-appropriate, validated and culturally adapted digital DATs is essential to strengthen dietary surveillance and guide effective nutrition policies across the region. CI - (c) The Author(s) 2026. FAU - Vidal, Milca AU - Vidal M AUID- ORCID: 0009-0002-9328-8981 AD - Food Science and Nutrition, University of Leeds Faculty of Environment, UK. ROR: https://ror.org/024mrxd33 FAU - Iqbal, Muhammed AU - Iqbal M AD - Food Science and Nutrition, University of Leeds Faculty of Environment, UK. ROR: https://ror.org/024mrxd33 AD - Clinical nutrition, Politeknik Negeri Jember, Indonesia. FAU - Cade, Janet AU - Cade J AD - Nutrition Epidemiology Group, University of Leeds, UK. FAU - Nykjaer, Camilla AU - Nykjaer C AD - School of Biomedical Sciences, University of Leeds Faculty of Biological Sciences, UK. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260617 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 SB - IM MH - Humans MH - Child MH - Adolescent MH - Latin America MH - *Nutrition Assessment MH - Child, Preschool MH - *Diet MH - *Diet Surveys/methods PMC - PMC13279971 OTO - NOTNLM OT - Adolescents OT - Children OT - Dietary assessment tool OT - Latin America OT - Scoping Review COIS- The author(s) declare none. EDAT- 2026/06/22 13:42 MHDA- 2026/06/22 19:00 PMCR- 2026/06/17 CRDT- 2026/06/22 06:59 PHST- 2025/11/10 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/22 19:00 [medline] PHST- 2026/06/22 13:42 [pubmed] PHST- 2026/06/22 06:59 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - S2048679026101165 [pii] AID - 10.1017/jns.2026.10116 [doi] PST - epublish SO - J Nutr Sci. 2026 Jun 17;15:e46. doi: 10.1017/jns.2026.10116. eCollection 2026. PMID- 42325327 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260622 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Family sports environment and emotional regulation in Chinese adolescents: the mediating roles of sports lifestyle and parent-child interaction. PG - 1812203 LID - 10.3389/fpsyg.2026.1812203 [doi] LID - 1812203 AB - Against the backdrop of increasingly prominent mental health issues among adolescents, insufficient development of the family sports environment, a key external factor associated with emotional regulation, has emerged as a critical but often overlooked determinant of psychological stability and resilience among Chinese youth. In particular, the absence of an active sports lifestyle and structured parent-child interaction patterns may be associated with impaired emotional regulation processes, highlighting the need to examine the associational pathways. OBJECTIVE: This study aimed to investigate the association between the family sports environment and emotional regulation abilities among Chinese adolescents and to explore the serial indirect associations of sports; lifestyle and parent-child relationship within a theoretically informed mediation model. METHODS: A cluster sampling survey was conducted among 750 Chinese adolescents. Data were collected using the Family Sports Environment Scale, the Adolescent Emotional Regulation Scale, the Sports Lifestyle Scale, and the Parent-Child Relationship Scale. All variables were measured at a single time point using self-report questionnaires. RESULTS: (1) No statistically significant differences were observed across gender or age in family sports environment, emotional regulation, sports lifestyle, or parent-child relationship (p > 0.05); (2) The family sports environment was significantly and positively associated with emotional regulation (r = 0.698, p < 0.001). Regression analyses indicated that the total effect of family sports environment on emotional regulation was significant (unstandardized coefficient, B = 0.292; t = 26.811, p < 0.001). while the direct effect also remained significant (standardized coefficient,beta = 0.207; t = 3.829, p < 0.001). In addition, the family sports environment was significantly associated with variations in sports lifestyle (B = 1.957, t = 37.969, p < 0.001) and parent-child relationship (B = 0.292, t = 8.445, p < 0.001). Sports lifestyle was significantly associated with variations in parent-child relationship (beta = 0.226, t = 15.931, p < 0.001) and emotional regulation (beta = 0.203, t = 8.400, p < 0.001). Moreover, the parent-child relationship was significantly associated with variations in emotional regulation (beta = 0.524, t = 9.175, p < 0.001); (3) Sports lifestyle and parent-child relationship both demonstrated significant mediating associations in the relationship between family sports environment and adolescent emotional regulation, consistent with a serial mediation model of associations. CONCLUSION: The family sports environment was significantly associated with healthier sports lifestyles among Chinese adolescents and more positive parent-child relationships, and was also indirectly associated with emotional regulation abilities through the sequential mediating effects of these two factors. Sports lifestyles and parent-child relationships function as key intermediary pathways linking the family sports environment to adolescents' emotional regulation, thereby providing a theoretically informed explanation of the observed associative pathways. From a practical perspective, these findings suggest that optimizing the family sports environment, encouraging parent-child engagement in physical activities, and fostering regular physical activity habits among adolescents may be supportive contextual factors for improving emotional regulation and supporting mental health development. Such strategies may also provide valuable implications for family-based sports guidance and adolescent mental health support practices. However, this study is subject to limitations related to sample representativeness and cross-sectional research design. Future research is encouraged to employ longitudinal designs and incorporate more comprehensive family-context variables to further examine and validate these associations. CI - Copyright (c) 2026 Zhou, Liu and Xiang. FAU - Zhou, Zhixing AU - Zhou Z AD - School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. FAU - Liu, Weijian AU - Liu W AD - School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. FAU - Xiang, Jun AU - Xiang J AD - School of Physical Education and Health, Zhaoqing University, Zhaoqing, China. LA - eng PT - Journal Article DEP - 20260604 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13275267 OTO - NOTNLM OT - adolescents OT - emotional regulation OT - family sports environment OT - mediating effect OT - mental health OT - parent-child relationship OT - psychological resilience OT - sports lifestyle COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/22 13:42 MHDA- 2026/06/22 13:43 PMCR- 2026/06/04 CRDT- 2026/06/22 06:56 PHST- 2026/02/16 00:00 [received] PHST- 2026/04/27 00:00 [revised] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/06/22 13:43 [medline] PHST- 2026/06/22 13:42 [pubmed] PHST- 2026/06/22 06:56 [entrez] PHST- 2026/06/04 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1812203 [doi] PST - epublish SO - Front Psychol. 2026 Jun 4;17:1812203. doi: 10.3389/fpsyg.2026.1812203. eCollection 2026. PMID- 42325257 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260926 IS - 2046-1402 (Electronic) IS - 2046-1402 (Linking) VI - 14 DP - 2025 TI - Gender and Narrative Writing in Elementary Schools: A Qualitative Study Supporting Inclusive Education. PG - 1317 LID - 10.12688/f1000research.171604.2 [doi] LID - 1317 AB - BACKGROUND: This study investigates gender differences in narrative writing among primary school students to promote inclusive education, as narrative writing reflects embedded gender norms that influence literacy development and classroom equity. By examining these differences, this study aims to highlight how gender stereotypes can marginalize certain narrative styles and inform pedagogical strategies for Indonesian schools. METHODS: This qualitative case study with quantitative analysis examined 33 handwritten narratives from fifth-grade students (12 boys, 21 girls) and interviews with 10 students. SES data were collected through a parent questionnaire covering education, occupation, and home literacy environment. Two blind raters evaluated the narratives, with moderate inter-rater reliability (Cohen's kappa = 0.434). Thematic analysis was supplemented with t-tests and Pearson correlations to examine gender differences and the relationship between SES and narrative quality. RESULTS: The results showed that female students excelled notably in organization (mean score 18,4 vs. 15,1 for males), grammar (9,95 vs. 8,15), and writing conventions (2,7 vs. 2,2), indicating greater coherence, grammatical accuracy, and technical precision in their narratives. In contrast, male students scored slightly higher on content (26 vs. 25,3), driven by a marginally higher focus on characterization, though females led in plot complexity and setting detail. Language scores were comparable between genders. The overall final narrative score favored females (68,95 vs. 63,95). Correlation analysis revealed significant relationships between maternal education, home literacy environment, and narrative quality. CONCLUSIONS: Gender stereotypes shape literacy practices and may perpetuate educational inequalities. The study recommends gender-sensitive rubrics, cross-gender writing exercises, and teacher training to support inclusive education that validates diverse student voices. CI - Copyright: (c) 2026 Wulan Anggraeni S et al. FAU - Wulan Anggraeni, Sri AU - Wulan Anggraeni S AUID- ORCID: 0009-0006-4178-7403 AD - Faculty of Education Sciences, Universitas Pendidikan Indonesia Fakultas Ilmu Pendidikan, Bandung, West Java, 40154, Indonesia. AD - Faculty of Teacher Training and Education, Universitas Buana Perjuangan Karawang, Karawang Regency, West Java, 41361, Indonesia. FAU - Sunendar, Dadang AU - Sunendar D AD - Faculty of Language and Literature Education, Universitas Pendidikan Indonesia Fakultas Pendidikan Bahasa dan Seni, Bandung, West Java, 40154, Indonesia. FAU - Cahyani, Isah AU - Cahyani I AD - Faculty of Language and Literature Education, Universitas Pendidikan Indonesia Fakultas Pendidikan Bahasa dan Seni, Bandung, West Java, 40154, Indonesia. LA - eng SI - figshare/10.6084/m9.figshare.31697821 PT - Journal Article DEP - 20260502 PL - England TA - F1000Res JT - F1000Research JID - 101594320 SB - IM MH - Humans MH - Female MH - *Writing MH - Male MH - *Schools MH - Child MH - *Narration MH - Qualitative Research MH - Students MH - Sex Factors PMC - PMC13282602 OTO - NOTNLM OT - elementary education OT - gender and literacy OT - gender stereotypes OT - inclusive education OT - narrative writing COIS- No competing interests were disclosed. EDAT- 2026/06/22 13:43 MHDA- 2026/06/22 13:44 PMCR- 2026/05/02 CRDT- 2026/06/22 06:55 PHST- 2026/03/14 00:00 [accepted] PHST- 2026/06/22 13:44 [medline] PHST- 2026/06/22 13:43 [pubmed] PHST- 2026/06/22 06:55 [entrez] PHST- 2026/05/02 00:00 [pmc-release] AID - 10.12688/f1000research.171604.2 [doi] PST - epublish SO - F1000Res. 2026 May 2;14:1317. doi: 10.12688/f1000research.171604.2. eCollection 2025. PMID- 42324999 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20260922 IS - 1524-4539 (Electronic) IS - 0009-7322 (Print) IS - 0009-7322 (Linking) VI - 154 IP - 7 DP - 2026 Aug 18 TI - Consumption of Fructose-Containing Food and Beverage Sources in Childhood Through to Adulthood and Risk of Hypertension: A Prospective Cohort Study. PG - 612-623 LID - 10.1161/CIRCULATIONAHA.125.077666 [doi] AB - BACKGROUND: High intakes of fructose-containing sugars among children and adolescents is implicated in obesity and related comorbidities, including hypertension. However, sugar-sweetened beverages (SSBs), fruit juices, and whole fruit have different nutritional profiles and matrices, which may confer different effects on blood pressure. METHODS: GUTS (Growing Up Today Study) is a longitudinal cohort of 25 749 individuals (55% female) drawn from 2 enrollment waves, GUTS 1 (n=16 875; baseline 1996) and GUTS II (n=10 918; baseline 2004), followed up prospectively through 2021 (mean age at enrollment, 12 years; mean age at end of follow-up, 36 years). Participants provided updated information on lifestyle, health status, and habitual diet through validated food frequency questionnaires every 1 to 4 years. We conducted multivariable adjusted Cox proportional hazards regression models to estimate the associations of total fructose and SSB, fruit juice, and whole fruit intake (cumulative averages) with incident hypertension (hazard ratios [HRs] and 95% CIs), adjusting for major diet and lifestyle factors. We also modeled substitutions of SSBs or fruit juice with whole fruit, milk, and water. RESULTS: During up to 25 years of follow-up, 1625 participants (6.3%) reported a hypertension diagnosis. Total fructose intake was not associated with incident hypertension (highest versus lowest quintile HR, 1.07 [95% CI, 0.92, 1.25]; P(trend)<0.001). However, participants with the highest intake of SSBs (>/=2 servings/d versus <3 servings/week) and fruit juice (>/=1.5 servings/d versus <1 serving/wk) had a higher risk of hypertension (HR, 1.52 [95% CI, 1.27, 1.83]; P(trend)<0.001 and HR, 1.35 [95% CI, 1.06, 1.71]; P(trend)=0.018, respectively). In contrast, whole fruit was not associated with hypertension (highest versus lowest category HR, 0.79 [95% CI, 0.59, 1.05]; P(trend)=0.08). Replacing 1 serving/d of SSB with milk, water, or whole fruit was associated with a 13% (95% CI, 5%, 20%), 9% (95% CI, 3%, 15%), and 22% (95% CI, 11%, 31%) lower risk of hypertension, respectively. In addition, replacing fruit juice with whole fruit was associated with a 19% (95% CI, 3%, 32%) lower risk of hypertension. CONCLUSIONS: SSB and fruit juice intakes were positively associated with a higher risk of hypertension independently of overall diet quality, physical activity, and other factors. Our findings support public health guidelines to limit the overconsumption of SSBs and fruit juice starting in childhood to protect against the development of hypertension. FAU - Nguyen, Michelle AU - Nguyen M AD - Department of Nutritional Sciences, Temerty Faculty of Medicine (M.N., A.J.H., C.S.B., J.L.S., V.S.M.). FAU - AlEssa, Hala B AU - AlEssa HB AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Public Health Practice, College of Public Health, Kuwait University, Kuwait City (H.B.A.). FAU - Glenn, Andrea J AU - Glenn AJ AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Nutrition and Food Studies, New York University, New York City (A.J.G.). FAU - Tobias, Deirdre K AU - Tobias DK AUID- ORCID: 0000-0003-0020-9552 AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Medicine, Division of Preventive Medicine (D.K.T.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA. FAU - Chavarro, Jorge E AU - Chavarro JE AUID- ORCID: 0000-0002-4436-9630 AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Epidemiology (J.E.C., W.C.W., F.B.H.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Medicine, Channing Division of Network Medicine (J.E.C., F.B.H.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA. FAU - Willett, Walter C AU - Willett WC AUID- ORCID: 0000-0003-1458-7597 AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Epidemiology (J.E.C., W.C.W., F.B.H.), Harvard T.H. Chan School of Public Health, Boston, MA. FAU - Hu, Frank B AU - Hu FB AUID- ORCID: 0000-0002-8233-6274 AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Epidemiology (J.E.C., W.C.W., F.B.H.), Harvard T.H. Chan School of Public Health, Boston, MA. AD - Department of Medicine, Channing Division of Network Medicine (J.E.C., F.B.H.), Brigham and Women's Hospital and Harvard Medical School, Boston, MA. FAU - Hanley, Anthony J AU - Hanley AJ AD - Department of Nutritional Sciences, Temerty Faculty of Medicine (M.N., A.J.H., C.S.B., J.L.S., V.S.M.). AD - Division of Endocrinology (A.J.H.), University of Toronto, ON Canada. AD - Leadership Sinai Centre for Diabetes, Mount Sinai Hospital, Toronto, ON, Canada (A.J.H.). FAU - Birken, Catherine S AU - Birken CS AUID- ORCID: 0000-0003-0308-8645 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine (M.N., A.J.H., C.S.B., J.L.S., V.S.M.). AD - Department of Paediatrics (C.S.B.), University of Toronto, ON Canada. AD - Department of Medicine, Temerty Faculty of Medicine (C.S.B., J.L.S.), University of Toronto, ON Canada. AD - Child Health Evaluative Sciences, SickKids Research Institute, Toronto, ON, Canada (C.S.B.). FAU - Sievenpiper, John L AU - Sievenpiper JL AUID- ORCID: 0000-0002-3270-5772 AD - Department of Nutritional Sciences, Temerty Faculty of Medicine (M.N., A.J.H., C.S.B., J.L.S., V.S.M.). AD - Department of Medicine, Temerty Faculty of Medicine (C.S.B., J.L.S.), University of Toronto, ON Canada. AD - Toronto 3D Knowledge Synthesis & Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, Division of Endocrinology & Metabolism, and Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, ON, Canada (J.L.S.). FAU - Malik, Vasanti S AU - Malik VS AD - Department of Nutritional Sciences, Temerty Faculty of Medicine (M.N., A.J.H., C.S.B., J.L.S., V.S.M.). AD - Department of Nutrition (H.B.A., A.J.G., D.K.T., J.E.C., W.C.W., F.B.H., V.S.M.), Harvard T.H. Chan School of Public Health, Boston, MA. LA - eng GR - U01 HL145386/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260622 PL - United States TA - Circulation JT - Circulation JID - 0147763 RN - 30237-26-4 (Fructose) SB - IM MH - Humans MH - Female MH - *Fructose/adverse effects/administration & dosage MH - *Hypertension/epidemiology/diagnosis/etiology MH - Child MH - Prospective Studies MH - Male MH - *Sugar-Sweetened Beverages/adverse effects MH - Risk Factors MH - Adolescent MH - *Fruit and Vegetable Juices/adverse effects MH - Adult MH - *Beverages/adverse effects MH - Longitudinal Studies MH - Young Adult MH - Fruit MH - Incidence PMC - PMC13288772 MID - NIHMS2176243 OTO - NOTNLM OT - fructose OT - fruit OT - fruit and vegetable juices OT - hypertension OT - sugar-sweetened beverages COIS- Dr AlEssa is supported by the 2017 Faculty Research grant at the Middle East Initiative, Harvard Kennedy School by the Kuwait Foundation for the Advancement of Sciences, and by the Cardiovascular Health Research Grant 2023 by the Kuwait Heart Foundation. Dr Tobias is funded by the National Institutes of Health/National Institute for National Institute of Diabetes and Digestive and Kidney Diseases for related research. Dr Glenn has received travel support and/or honoraria from the Lawson Centre Nutrition Digital Series (University of Toronto), the Good Food Institute, Vinasoy, and the British Nutrition Society. Dr Hanley has received research grants from the Canadian Institutes of Health Research, Diabetes Canada, the Canadian Foundation for Innovation, the Canada Research Chairs Program, the Canadian Foundation for Innovation, and Dairy Farmers of Canada. Dr Sievenpiper has received research support from the Canadian Foundation for Innovation, Ontario Research Fund, Province of Ontario Ministry of Research and Innovation and Science, Canadian Institutes of Health Research, Diabetes Canada, American Society for Nutrition, National Honey Board (US Department of Agriculture honey "Checkoff" program), Institute for the Advancement of Food and Nutrition Sciences, Pulse Canada, Quaker Oats Center of Excellence, INC International Nut and Dried Fruit Council Foundation, The United Soybean Board (US Department of Agriculture soy "Checkoff" program), Protein Industries Canada (a government of Canada Global Innovation Cluster), Almond Board of California, European Fruit Juice Association, The Tate and Lyle Nutritional Research Fund at the University of Toronto, The Glycemic Control and Cardiovascular Disease in Type 2 Diabetes Fund at the University of Toronto (a fund established by the Alberta Pulse Growers), The Plant Protein Fund at the University of Toronto (a fund that has received contributions from IFF among other donors), The Plant Milk Fund at the University of Toronto (a fund established by the Karuna Foundation through Vegan Grants), and The Nutrition Trialists Network Fund at the University of Toronto (a fund established by donations from the Calorie Control Council, Physicians Committee for Responsible Medicine, and Login5 Foundation). He has received food donations to support randomized controlled trials from the Almond Board of California, California Walnut Commission, Danone, Nutrartis, Soylent, and Dairy Farmers of Canada. He has received travel support, speaker fees, and/or honoraria from FoodMinds LLC, Nestle, Abbott, General Mills, Nutrition Communications, International Food Information Council, Arab Beverage Association, International Sweeteners Association, Calorie Control Council, Phynova, International Stevia Council, Mantra Pharma Inc, Chinese Institute of Food Science and Technology, and Collaborative CME and Research Network. He has or has had ad hoc consulting arrangements with Almond Board of California, Perkins Coie LLP, Tate & Lyle, Ingredion, and Brightseed. He is on the Clinical Practice Guidelines Expert Committees of Diabetes Canada, European Association for the Study of Diabetes, Canadian Cardiovascular Society, and Obesity Canada/Canadian Association of Bariatric Physicians and Surgeons. He serves as an unpaid member of the Board of Trustees of the Institute for the Advancement of Food and Nutrition Sciences. He is a director at large of the Canadian Nutrition Society, founding member of the International Carbohydrate Quality Consortium, Executive Board member of the Diabetes and Nutrition Study Group of the European Association for the Study of Diabetes, and director of the Toronto 3D Knowledge Synthesis and Clinical Trials foundation. His spouse is a former employee of Nestle Health Science and AB InBev. Dr Malik has received funding from the Canada Research Chairs Program; Connaught New Researcher Award, University of Toronto; The Joannah & Brian Lawson Centre for Child Nutrition, University of Toronto; Temerty Faculty of Medicine Pathway Grant, University of Toronto; Canada Foundation for Innovation; Ontario Research Fund, Canadian Institutes of Health Research, National Institutes of Health, and has served as a consultant for the City and County of San Francisco for litigation related to health warning labels on SSBs and on the Robert Wood Johnson Healthy Eating Research Advisory Committee for child beverage guidance. Dr Birken received funding from Canadian Institutes of Health Research, Heart & Stroke Foundation of Canada, Physician Services Inc, The Edwin S.H. Leong Centre for Healthy Children, University of Toronto and Hospital for Sick Children, the Centre for Addiction and Mental Health, Joannah & Brian Lawson Centre for Child Nutrition, University of Toronto, and a Walmart Canada Regional Community Grant, administered through SickKids Foundation. The other authors report no conflicts. EDAT- 2026/06/22 06:45 MHDA- 2026/08/17 17:45 PMCR- 2026/06/24 CRDT- 2026/06/22 05:03 PHST- 2026/08/17 17:45 [medline] PHST- 2026/06/22 06:45 [pubmed] PHST- 2026/06/22 05:03 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - 10.1161/CIRCULATIONAHA.125.077666 [doi] PST - ppublish SO - Circulation. 2026 Aug 18;154(7):612-623. doi: 10.1161/CIRCULATIONAHA.125.077666. Epub 2026 Jun 22. PMID- 42324958 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260911 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 83 IP - 3 DP - 2026 Sep TI - Development and validation of the new French ORALQUEST scale for evaluating feeding difficulties in young children. PG - 528-535 LID - 10.1002/jpn3.70491 [doi] AB - OBJECTIVE: Feeding difficulties are common in children with and without somatic conditions. Our objective was to develop a parent-report questionnaire (ORALQUEST) designed to be administered by a professional and to assess feeding difficulties in children aged 9 months to 6 years. METHODS: The questionnaire explores four domains: eating behavior, oral skills, tactile and oral sensitivity, and family environment. A validation study was done in 338 children seen for feeding difficulties (n = 74) or receiving follow-up for conditions at risk for feeding difficulties (n = 264). We assessed the validity and reliability of the tool and we conducted a receiver operating characteristic (ROC) analysis to determine the best total-score cutoff. RESULTS: The final version of the ORALQUEST has 40 items and produces a total score and four sub-scores. Structural validity, internal consistency, and reliability were excellent; convergent validity was good to acceptable but was challenging to assess given the absence of similar tools for comparisons. The optimal total-score cutoff was 27. Among children seen for feeding difficulties, 85% had a total score >/= 27. Total scores above the cutoff were less common than expected in children with chronic conditions (esophageal atresia, 39%; autism spectrum disorder, 42%; complex congenital heart disease, 29%; Robin sequence, 31%; and cleft palate, 18%). CONCLUSION: ORALQUEST for assessing feeding difficulties in young children demonstrated good psychometric properties in children with and without somatic conditions. The investigation by ORALQUEST of four domains may help to determine the best management strategy. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT04133038 (Clinicaltrials.gov) https://clinicaltrials.gov/study/NCT04133038. CI - (c) 2026 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Thouvenin, Beatrice AU - Thouvenin B AD - General Paediatric Unit, Necker University Hospital, Paris, France. FAU - Ould-Ammar, Redha AU - Ould-Ammar R AD - Unit of Clinical Research, AP-HP, University Necker Hospital, Paris, France. FAU - Ouss, Lisa AU - Ouss L AD - Child Psychiatry Unit, Necker University Hospital, Paris, France. FAU - Gavelle, Pascale AU - Gavelle P AD - Maxillo Facial Surgery Unit, Necker University Hospital, Paris, France. FAU - Disnan, Giulia AU - Disnan G AD - Paediatric Surgery, Necker University Hospital, Paris, France. FAU - Royer, Aurelie AU - Royer A AD - General Paediatric Unit, Necker University Hospital, Paris, France. AD - Reference Centre for Rare Disease <>, Necker University Hospital, Paris, France. FAU - Vegas, Nancy AU - Vegas N AD - General Paediatric Unit, Necker University Hospital, Paris, France. AD - Reference Centre for Rare Disease <>, Necker University Hospital, Paris, France. AD - Paris Cite University, Paris, France. FAU - Fraysseix, Catherine du AU - Fraysseix CD AD - General Paediatric Unit, Necker University Hospital, Paris, France. FAU - Adnot, Pauline AU - Adnot P AD - General Paediatric Unit, Necker University Hospital, Paris, France. AD - Reference Centre for Rare Disease <>, Necker University Hospital, Paris, France. FAU - Barbieri, Valeria AU - Barbieri V AD - General Paediatric Unit, Necker University Hospital, Paris, France. FAU - Hassler, Christine AU - Hassler C AD - CESP Centre of Epidemiology and Population Health, INSERM, Villejuif, France. FAU - Elie, Caroline AU - Elie C AD - Unit of Clinical Research, AP-HP, University Necker Hospital, Paris, France. AD - Universite Paris Cite, Inserm, Pharmacologie et Evaluations Des Therapeutiques Chez L'enfant Et La Femme Enceinte, Paris, France. FAU - Barry, Caroline AU - Barry C AD - CESP Centre of Epidemiology and Population Health, INSERM, Villejuif, France. FAU - Abadie, Veronique AU - Abadie V AUID- ORCID: 0000-0002-3525-1921 AD - General Paediatric Unit, Necker University Hospital, Paris, France. AD - Reference Centre for Rare Disease <>, Necker University Hospital, Paris, France. AD - Paris Cite University, Paris, France. AD - CESP Centre of Epidemiology and Population Health, INSERM, Villejuif, France. LA - eng SI - ClinicalTrials.gov/NCT04133038 GR - Assistance Publique - Hopitaux de Paris/ PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20260622 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - *Feeding and Eating Disorders of Childhood/diagnosis/psychology MH - *Feeding Behavior/psychology MH - Parents MH - Psychometrics MH - Reproducibility of Results MH - ROC Curve MH - Surveys and Questionnaires/standards PMC - PMC13539697 OTO - NOTNLM OT - assessment OT - pediatric nutrition OT - psychometric qualities COIS- The authors declare no conflicts of interest. EDAT- 2026/06/22 06:46 MHDA- 2026/09/03 17:36 PMCR- 2026/09/03 CRDT- 2026/06/22 04:23 PHST- 2026/05/20 00:00 [revised] PHST- 2025/11/23 00:00 [received] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/09/03 17:36 [medline] PHST- 2026/06/22 06:46 [pubmed] PHST- 2026/06/22 04:23 [entrez] PHST- 2026/09/03 00:00 [pmc-release] AID - JPN370491 [pii] AID - 10.1002/jpn3.70491 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Sep;83(3):528-535. doi: 10.1002/jpn3.70491. Epub 2026 Jun 22. PMID- 42324895 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260813 IS - 1097-0142 (Electronic) IS - 0008-543X (Print) IS - 0008-543X (Linking) VI - 132 IP - 13 DP - 2026 Jul 1 TI - Demographic, birth, parental characteristics, and the risk of early-onset colorectal cancer: A population-based nested case-control study in California. PG - e70458 LID - 10.1002/cncr.70458 [doi] LID - e70458 AB - BACKGROUND: The incidence of early-onset colorectal cancer (EOCRC), defined as colorectal cancer diagnosed before the age of 50 years, has been increasing. The relationship between demographic, birth, and parental characteristics and risk of EOCRC has not been elucidated. METHODS: This study included 1221 cases born and diagnosed with EOCRC at the age of 0 to 39 years in California during 1988 through 2021 and 61,050 frequency-matched controls based on birth year. Odds ratios (OR) and 95% CIs were estimated using multivariable logistic regression models. RESULTS: Based on multivariable analysis, males had 34% higher risk of EOCRC compared to females (OR = 1.34; 95% CI, 1.20-1.51), and Hispanic ethnicity was associated with 43% higher risk of EOCRC (OR for Hispanic versus non-Hispanic White = 1.34; 95% CI, 1.20-1.51). Having a foreign-born mother was associated with a lower risk of EOCRC (OR = 0.85; 95% CI, 0.73-0.97). Among females, every 500-g increase in birthweight was associated with 10% increase in EOCRC risk (OR = 1.10; 95% CI, 1.01-1.21) and having a father aged >/=35 years was associated with higher risk of EOCRC (OR = 1.56; 95% CI, 1.08-2.25). No other demographic, birth, and parental characteristic was significantly associated with risk of EOCRC. CONCLUSION: High birthweight, male sex, Hispanic ethnicity, and older paternal age are potential risk factors for EOCRC. Maternal birthplace, which is associated with diet, smoking patterns, other health-promoting characteristics, may be protective against EOCRC. These factors require future research for validation and evaluation of possible mechanisms. CI - (c) 2026 The Author(s). Cancer published by Wiley Periodicals LLC on behalf of American Cancer Society. FAU - Siddique, Sunny AU - Siddique S AUID- ORCID: 0000-0002-5746-1161 AD - Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA. FAU - Wang, Rong AU - Wang R AUID- ORCID: 0000-0002-2169-4174 AD - Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA. FAU - Berardi, Domenica AU - Berardi D AD - Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA. FAU - Johnson, Caroline H AU - Johnson CH AD - Department of Environmental Health Sciences, Yale School of Public Health, New Haven, Connecticut, USA. FAU - Wiemels, Joseph L AU - Wiemels JL AD - Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. FAU - Metayer, Catherine AU - Metayer C AUID- ORCID: 0000-0003-3467-4145 AD - Division of Epidemiology, School of Public Health, University of California, Berkeley, California, USA. FAU - Ma, Xiaomei AU - Ma X AD - Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA. LA - eng GR - F31 CA281335/CA/NCI NIH HHS/United States GR - 2T32CA250803-06/CA/NCI NIH HHS/United States PT - Journal Article PL - United States TA - Cancer JT - Cancer JID - 0374236 SB - IM MH - Humans MH - Female MH - California/epidemiology MH - *Colorectal Neoplasms/epidemiology MH - Male MH - Case-Control Studies MH - Risk Factors MH - Adult MH - Infant MH - Infant, Newborn MH - Adolescent MH - Child, Preschool MH - Child MH - Young Adult MH - Age of Onset MH - Parents MH - Birth Weight MH - Incidence MH - Paternal Age PMC - PMC13284631 OTO - NOTNLM OT - Hispanic ethnicity OT - birth characteristics OT - birthweight OT - colorectal cancer risk factors OT - early-life exposures OT - early-onset colorectal cancer OT - parental characteristics OT - paternal age OT - sex differences COIS- R.W. reported receiving grants from Flatiron Health outside the submitted work. X.M. reported receiving consultation fees from Bristol Myers Squibb outside the submitted work. EDAT- 2026/06/22 06:46 MHDA- 2026/06/22 13:42 PMCR- 2026/06/22 CRDT- 2026/06/22 03:12 PHST- 2026/04/17 00:00 [revised] PHST- 2025/11/21 00:00 [received] PHST- 2026/04/24 00:00 [accepted] PHST- 2026/06/22 13:42 [medline] PHST- 2026/06/22 06:46 [pubmed] PHST- 2026/06/22 03:12 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - CNCR70458 [pii] AID - 10.1002/cncr.70458 [doi] PST - ppublish SO - Cancer. 2026 Jul 1;132(13):e70458. doi: 10.1002/cncr.70458. PMID- 42324459 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260908 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 22 TI - Determinants of out-of-home food consumption: development and validation of a multidimensional scale in a Brazilian sample. LID - 10.1186/s12889-026-28251-x [doi] LID - 2509 AB - BACKGROUND: Out-of-home food consumption has become an integral component of contemporary dietary patterns, particularly in urban contexts. Evidence suggests that eating outside the home is associated with diet quality, nutritional intake, and broader public health outcomes. However, Brazil lacks validated multidimensional instruments capable of comprehensively assessing the economic, behavioral, and experiential determinants underlying this behavior. This study aimed to develop and validate the Scale of Determinant Factors in Out-of-Home Food Consumption (SDF-OHFC) and to examine the structural relationships among its dimensions. METHODS: A cross-sectional study was conducted with 426 Brazilian adults who reported consuming food outside the home at least once per week. Data were collected through an online survey and analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM). The measurement model was assessed for reliability, convergent and discriminant validity. Structural relationships were tested using bootstrapping procedures (5,000 resamples), and predictive performance was evaluated through R(2), Q(2), RMSE, and MAE. Measurement invariance was examined across sex, marital status, and geographic regions. RESULTS: The SDF-OHFC comprises five dimensions: economic aspects, convenience, habits and personal preferences, social and experiential aspects, and perceived food quality. The scale demonstrated satisfactory internal consistency (Cronbach's alpha = 0.705-0.762), composite reliability (> 0.70), and convergent validity (AVE > 0.50). All hypothesized structural relationships were statistically significant (p < 0.05). Economic aspects played a central antecedent role, positively influencing convenience and habits, and negatively influencing social and experiential aspects. Convenience and social and experiential dimensions were positively associated with perceived food quality. Structural invariance was confirmed across all tested demographic groups. CONCLUSIONS: The SDF-OHFC is a valid and reliable multidimensional instrument for assessing determinants of out-of-home food consumption in Brazil. By integrating economic, behavioral, and experiential factors within a single framework, the scale supports public health research and policy development aimed at improving urban food environments, promoting healthier eating practices, and addressing structural determinants of dietary behavior. CI - (c) 2026. The Author(s). FAU - Lopes, Luis Felipe Dias AU - Lopes LFD AUID- ORCID: 0000-0002-2438-0226 AD - Federal University of Santa Maria, Santa Maria, Brazil. lflopes67@yahoo.com.br. FAU - Pegoraro, Daniela AU - Pegoraro D AD - Federal University of Santa Maria, Santa Maria, Brazil. FAU - de Oliveira, Rayssa Cleide AU - de Oliveira RC AD - Federal University of Santa Maria, Santa Maria, Brazil. FAU - Lopes, Eduarda Grando AU - Lopes EG AD - Federal University of Santa Maria, Santa Maria, Brazil. FAU - Saragozo, Rosangela Arruda AU - Saragozo RA AD - Federal University of Santa Maria, Santa Maria, Brazil. FAU - da Silva, Deoclecio Junior Cardoso AU - da Silva DJC AD - Pontifical Catholic University of Parana, Curitiba, Brazil. LA - eng PT - Journal Article PT - Validation Study DEP - 20260622 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Brazil MH - Female MH - Male MH - Cross-Sectional Studies MH - Adult MH - Reproducibility of Results MH - Middle Aged MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires/standards MH - Young Adult MH - Adolescent MH - Socioeconomic Factors PMC - PMC13536861 OTO - NOTNLM OT - Brazil OT - Eating behavior OT - Food environment OT - Out-of-home food consumption OT - Psychometric validation OT - Public health COIS- Declarations. Ethical approval and consent to participate: This study was conducted in accordance with the ethical standards for research involving human participants. The research protocol was reviewed and approved by the Research Ethics Committee of the Federal University of Santa Maria, Brazil (Approval No. 4,469,026; CAAE: 40303720.5.0000.5346). All participants provided informed consent prior to participation. Data collection was anonymous, voluntary, and conducted in compliance with national and international ethical guidelines. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/22 00:43 MHDA- 2026/09/02 05:36 PMCR- 2026/06/22 CRDT- 2026/06/21 23:29 PHST- 2026/02/14 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/09/02 05:36 [medline] PHST- 2026/06/22 00:43 [pubmed] PHST- 2026/06/21 23:29 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - 10.1186/s12889-026-28251-x [pii] AID - 28251 [pii] AID - 10.1186/s12889-026-28251-x [doi] PST - epublish SO - BMC Public Health. 2026 Jun 22;26(1):2509. doi: 10.1186/s12889-026-28251-x. PMID- 42324338 OWN - NLM STAT- Publisher LR - 20260721 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Jun 21 TI - Serum inflammatory and metabolic signatures accelerate precocious puberty in obese children. LID - 10.1038/s41390-026-05214-x [doi] AB - BACKGROUND: This study aimed to characterize the interplay of metabolic, hormonal, and inflammatory factors in precocious puberty and obesity. METHODS: This cross-sectional study enrolled 417 children were included Control (n = 97), Obesity (n = 102), Central Precocious Puberty (CPP, n = 103), and obesity with precocious puberty group (OPP, n = 115) groups. Basic anthropometric, hormonal, metabolic, and inflammatory indicators were analyzed. Group comparisons were performed using ANOVA/Kruskal-Wallis tests. Receiver operating characteristic (ROC) curve was applied to assess biomarkers for predicting precocious puberty in obese children, and Spearman correlation evaluated biomarker relationships. RESULTS: Bone age advancement and elevated levels of LH, FSH, and IGF-1 were observed in both the CPP and OPP group compared to the Controls. ROC curve indicated that IGF-1 had high predictive value (AUC = 0.810) for precocious puberty in obese children. The Obesity and OPP groups exhibited significantly elevated triglycerides, liver enzymes (GGT, ALT), and inflammatory indices (NLR, WBC) relative to the CPP group. OPP correlated positively with LH, FSH, TC, NLR, and IGF-1. CONCLUSION: Obesity-associated precocious puberty involves concurrent elevations in hormonal, metabolic, and inflammatory biomarkers. Clinical management of pubertal disorders in children with obesity should incorporate integrated assessment of inflammatory and metabolic dysregulation alongside endocrine markers. IMPACT: It provides comparative evidence that the obesity-associated precocious puberty exhibits a more severe metabolic and inflammatory profile than the Central Precocious Puberty without obesity, suggesting obesity exacerbates these dysregulations alongside puberty timing. The findings strongly argue that clinical management of precocious puberty in obese children requires an integrated approach, assessing not just hormonal markers but also metabolic health and inflammation for comprehensive evaluation. It underscores the complex interplay and potential shared mechanisms between metabolic dysfunction, inflammation, and the hormonal activation of puberty, emphasizing the need for future research to investigate these interconnected pathways in pediatric endocrine disorders. CI - (c) 2026. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Wang, Li AU - Wang L AD - Reproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, China. FAU - Yan, Heqiu AU - Yan H AD - Reproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, China. FAU - Liu, Jun AU - Liu J AD - Reproductive Medicine Center, Key Laboratory of Reproductive Medicine, Sichuan Provincial Maternity and Child Health Care Hospital, the Affiliated Women's and Children's Hospital of Chengdu Medical College, Chengdu, China. FAU - Zhang, Jing AU - Zhang J AD - Department of Endocrine Genetics and Metabolism, School of Medicine, Chengdu Women's and Children's Center Hospital, University of Electronic Science and Technology of China, Chengdu, China. FAU - Cheng, Xinran AU - Cheng X AD - Department of Endocrine Genetics and Metabolism, School of Medicine, Chengdu Women's and Children's Center Hospital, University of Electronic Science and Technology of China, Chengdu, China. FAU - Yao, Haibo AU - Yao H AD - Department of Medical Records, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Tang, Fang AU - Tang F AD - Department of Endocrine Genetics and Metabolism, School of Medicine, Chengdu Women's and Children's Center Hospital, University of Electronic Science and Technology of China, Chengdu, China. FAU - Luo, Mengjun AU - Luo M AD - Department of Clinical Laboratory, Chengdu Women's and Children's Center Hospital. School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. 462816877@qq.com. LA - eng PT - Journal Article DEP - 20260621 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study was reviewed and approved by the Ethics Committee of Chengdu Women and Children's Central Hospital (Grant No.2021(140)) and conducted in accordance with the Declaration of Helsinki. The parents and/or legal guardian provided their written informed consent to participate in this study. EDAT- 2026/06/22 00:43 MHDA- 2026/06/22 00:43 CRDT- 2026/06/21 23:21 PHST- 2025/07/22 00:00 [received] PHST- 2026/05/22 00:00 [accepted] PHST- 2025/11/04 00:00 [revised] PHST- 2026/06/22 00:43 [pubmed] PHST- 2026/06/22 00:43 [medline] PHST- 2026/06/21 23:21 [entrez] AID - 10.1038/s41390-026-05214-x [pii] AID - 10.1038/s41390-026-05214-x [doi] PST - aheadofprint SO - Pediatr Res. 2026 Jun 21. doi: 10.1038/s41390-026-05214-x. PMID- 42324210 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260621 IS - 1476-4954 (Electronic) IS - 1476-4954 (Linking) VI - 39 IP - 1 DP - 2026 Dec TI - Association between maternal cardiovascular health assessed by modified Life's Essential 8 and risks of adverse pregnancy outcomes. PG - 2682080 LID - 10.1080/14767058.2026.2682080 [doi] AB - BACKGROUND: The American Heart Association (AHA) has updated the definition of cardiovascular health (CVH) from "Life's Simple 7" (LS7) to "Life's Essential 8" (LE8). The association between gestational LE8 CVH status and adverse pregnancy outcomes is unclear. METHODS: We recruited pregnant women from the China birth cohort study during 6-13(+6) gestation weeks and followed them up until delivery to identify pregnancy outcomes. According to the modified AHA definitions, baseline gestational modified LE8 (mLE8) and LS7 CVH scores were calculated based on body mass index, nicotine exposure, physical activity, diet, blood pressure, blood glucose, and lipid levels. Multivariable adjusted logistic regression and receiver operating characteristic (ROC) curves were used to investigate the association between gestational CVH and adverse pregnancy outcomes. RESULTS: Among the 5168 pregnant women finally included, the overall gestational mLE8 CVH score was 81.4 +/- 9.6 points. After multivariate adjustment, each 10-points increase in the total overall gestational mLE8 CVH score was significantly associated with a decreased risk of pregnancy loss [odds ratio (OR) = 0.85, 95% CI: 0.76-0.95), hypertensive disorders of pregnancy (OR = 0.50, 95% CI: 0.44-0.58), gestational diabetes mellitus (GDM) (OR = 0.62, 95% CI: 0.57-0.67), preterm birth (OR = 0.76, 95% CI: 0.67-0.86), large-for-gestational age (LGA) (OR = 0.81, 95% CI: 0.73-0.90), and cesarean delivery (OR = 0.77, 95% CI: 0.72-0.82)]. The areas under the ROC curves (AUC) of mLE8 were higher than those of LS7 for pregnancy loss (0.553 vs. 0.537, p = 0.031), GDM (0.626 vs. 0.615, p = 0.023), LGA (0.575 vs. 0.557, p = 0.016), and cesarean delivery (0.574 vs. 0.564, p = 0.005). CONCLUSIONS: Higher gestational mLE8 CVH scores in the first trimester are significantly associated with a lower risk of adverse pregnancy outcomes. Although the capacity to predict adverse pregnancy outcomes was modest, mLE8 slightly outperformed LS7 in predicting PE, GDM, LGA, and cesarean delivery. FAU - Gao, Shen AU - Gao S AD - Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Su, Shaofei AU - Su S AD - Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Zhang, Enjie AU - Zhang E AD - Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Zhang, Yue AU - Zhang Y AD - Department of Research Management, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Liu, Jianhui AU - Liu J AD - Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Xie, Shuanghua AU - Xie S AD - Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Cui, Yuchen AU - Cui Y AD - Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Li, Shuangying AU - Li S AD - Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Yue, Wentao AU - Yue W AD - Department of Research Management, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Liu, Ruixia AU - Liu R AD - Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. FAU - Yin, Chenghong AU - Yin C AD - Department of Central Laboratory, Beijing Obstetrics and Gynecology Hospital, Capital Medical University. Beijing Maternal and Child Health Care Hospital, Beijing, China. LA - eng PT - Journal Article DEP - 20260621 PL - England TA - J Matern Fetal Neonatal Med JT - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JID - 101136916 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adult MH - *Pregnancy Outcome/epidemiology MH - China/epidemiology MH - Infant, Large for Gestational Age MH - Risk Factors MH - Vascular Health MH - *Maternal Health MH - Infant, Newborn MH - Cohort Studies OTO - NOTNLM OT - Cardiovascular health OT - Life's Essential 8 OT - Life's Simple 7 OT - cohort study OT - pregnancy outcomes EDAT- 2026/06/22 00:43 MHDA- 2026/06/22 13:42 CRDT- 2026/06/21 22:23 PHST- 2026/06/22 13:42 [medline] PHST- 2026/06/22 00:43 [pubmed] PHST- 2026/06/21 22:23 [entrez] AID - 10.1080/14767058.2026.2682080 [doi] PST - ppublish SO - J Matern Fetal Neonatal Med. 2026 Dec;39(1):2682080. doi: 10.1080/14767058.2026.2682080. Epub 2026 Jun 21. PMID- 42323926 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260820 IS - 1873-2364 (Electronic) IS - 0960-8966 (Linking) VI - 65 DP - 2026 Aug TI - Systematic review of outcome measures in facioscapulohumeral dystrophy (FSHD): validated, usable, and feasible tools for assessing function, performance, and strength. PG - 106470 LID - S0960-8966(26)00138-0 [pii] LID - 10.1016/j.nmd.2026.106470 [doi] AB - Facioscapulohumeral dystrophy (FSHD) is a dominantly inherited muscle-wasting condition with no approved therapies. Symptom variability complicates clinical evaluation, and despite the necessity of function-based measures to bridge research and real-world outcomes, no international consensus on a core assessment set exists. This systematic review evaluated the psychometric properties, feasibility, and comprehensiveness of published function-based outcome measures in FSHD, to help guide late-phase trials, and clinical practice. A systematic search of six databases with a data cut in January 2026 identified 366 studies and 51 outcome measures, which were appraised using the COSMIN framework. The results showed that while the FSHD Clinical Score, Clinical Severity Score, and 6-minute walk test are the most frequently utilised, no measure achieved higher than a 'Moderate' rating. Most supporting evidence remains 'Low,' with critical gaps identified for wheelchair users and paediatric populations. Digital outcome measures showed promise for improving responsiveness and enabling remote assessment.Our systematic review highlights an urgent need for a consensus-based approach to harmonize data together with international efforts such as MOVE/RESOLVE-FSHD providing direct support to upcoming initiatives like ENMC-FSHD-outcomes- workshop and the PaLaDIn project. Such efforts will allow researchers to enhance real-world evidence synthesis and improve success of future clinical trials. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Hewamadduma, Channa AU - Hewamadduma C AD - Academic Unit of Neuromuscular Disorders, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, , UK; Sheffield Institute of Translational Neurosciences (SITRAN), School of Medicine and Population Health, University of Sheffield, Sheffield, , UK. Electronic address: chewamadduma1@sheffield.ac.uk. FAU - Street, Jon AU - Street J AD - Academic Unit of Neuromuscular Disorders, Sheffield Teaching Hospitals NHS Foundation Trust, Sheffield, , UK; Sheffield Institute of Translational Neurosciences (SITRAN), School of Medicine and Population Health, University of Sheffield, Sheffield, , UK. FAU - Massey, Charlotte AU - Massey C AD - Sheffield Institute of Translational Neurosciences (SITRAN), School of Medicine and Population Health, University of Sheffield, Sheffield, , UK. FAU - McDermott, Christopher J AU - McDermott CJ AD - Sheffield Institute of Translational Neurosciences (SITRAN), School of Medicine and Population Health, University of Sheffield, Sheffield, , UK. FAU - Weatherley, Emma AU - Weatherley E AD - FSHD Global Research Foundation, Sydney, Australia. FAU - Voermans, Nicol C AU - Voermans NC AD - Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, the Netherlands. FAU - Statland, Jeff AU - Statland J AD - Department of Neurology, University of Kansas Medical Center, Kansas City, KS, USA. FAU - Schoser, Benedikt AU - Schoser B AD - Friedrich-Baur-Institute, Department of Neurology LMU Clinic Munich, Munich, Germany. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260611 PL - England TA - Neuromuscul Disord JT - Neuromuscular disorders : NMD JID - 9111470 SB - IM MH - *Muscular Dystrophy, Facioscapulohumeral/physiopathology/diagnosis/therapy MH - Humans MH - *Outcome Assessment, Health Care MH - *Muscle Strength MH - Psychometrics MH - Severity of Illness Index OTO - NOTNLM OT - COSMIN OT - FSHD OT - Facioscapulohumeral muscular dystrophy OT - Outcome measures OT - Systematic review COIS- Declaration of competing interest CH: NCI/PI in clinical trials sponsored by UCB, Roche, Biogen, Avidity, Dyne, Argenx, JnJ, Remgen, Alexion, and Novartis and have received speaker honoraria and consultancy from UCB, Roche, Biogen, Avidity, Argenx, Alexion and Novartis. JS: received travel grant from FSHD Society CM: discloses the following conflicts of interest: Consultancy: Dyne therapeutics, Avidity, Lupin Neurosciences, Arthex Bio tech, PepGen. CJM: reports no conflicts of interest relevant to this work JS: received grant funding from NIH, CDC, MDA, FSHD Society, FSHD Canada, Friends of FSHD Research, ALSA; consultant or on scientific advisory board or steering committee for Avidity, Dyne, Roche, Novartis, Scholar Rock, Alnylam, Vertex, Souffle, Merck, and Sanofi NV: Consultancy: Avidity, Spolia, Astellas and Souffle (all financial compensation paid to her institution). BS: discloses the following conflicts of interest: Research support: DFG CAESAR, EU Horizon 2022 ComPASS; PaLaDIn; Entry-DM. Lecture support: Amicus, Alexion, Argenx, Astellas, Kedrion, Sanofi. Consultancy: Amicus, Astellas, Avidity, Denali, Dyne, Johnson&Johnson, Sanofi, Souffle, UCB. EDAT- 2026/06/21 22:33 MHDA- 2026/08/04 00:35 CRDT- 2026/06/21 17:59 PHST- 2026/04/18 00:00 [received] PHST- 2026/06/06 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/08/04 00:35 [medline] PHST- 2026/06/21 22:33 [pubmed] PHST- 2026/06/21 17:59 [entrez] AID - S0960-8966(26)00138-0 [pii] AID - 10.1016/j.nmd.2026.106470 [doi] PST - ppublish SO - Neuromuscul Disord. 2026 Aug;65:106470. doi: 10.1016/j.nmd.2026.106470. Epub 2026 Jun 11. PMID- 42323690 OWN - NLM STAT- MEDLINE DCOM- 20260911 LR - 20260913 IS - 1750-1172 (Electronic) IS - 1750-1172 (Linking) VI - 21 IP - 1 DP - 2026 Jun 20 TI - Karyotype-specific cardiovascular and metabolic profiles in Turner syndrome: a retrospective echocardiographic study. LID - 10.1186/s13023-026-04457-5 [doi] LID - 315 AB - BACKGROUND: Turner syndrome (TS) is associated with cardiovascular abnormalities and metabolic risk, but karyotype-specific phenotypes remain incompletely defined, particularly in pediatric and adolescent cohorts assessed by transthoracic echocardiography (TTE). METHODS: We conducted a retrospective cross-sectional study of 289 patients with TS evaluated between October 2016 and October 2023. Patients were grouped as 45,X monosomy (n = 149) or mosaic/structural karyotypes (n = 140). Baseline or preoperative TTE data were used. The primary endpoint was a clinically relevant structural cardiovascular disease (CVD) composite based on explicit baseline/preoperative diagnoses of major lesions; patent foramen ovale, isolated persistent left superior vena cava, and minor valve regurgitation were treated as descriptive findings. Aortic dilatation based on ASI > 20 mm/m(2) was analyzed separately as an aortic-size phenotype. RESULTS: The structural CVD composite was more frequent in the 45,X group than in the mosaic/structural group (49/149 [32.9%] vs. 26/140 [18.6%], p = 0.006). In multivariable logistic regression, 45,X remained associated with the structural CVD composite after adjustment for age, BMI, systolic blood pressure, LDL-C, and HOMA-IR (OR 1.88, 95% CI 1.05-3.35; p = 0.033). Aortic dilatation by ASI > 20 mm/m(2) did not differ significantly between groups (28.9% vs. 32.9%, p = 0.462). Elevated total cholesterol was more frequent in the 45,X group, and LDL-C was independently associated with the structural CVD composite. LVDD was modestly lower in the 45,X group (33.6 +/- 6.6 vs. 35.4 +/- 6.4 mm; p = 0.017). CONCLUSIONS: In this single-center TS cohort, 45,X monosomy was associated with a higher burden of clinically relevant structural cardiovascular abnormalities and an adverse lipid profile, whereas ASI-defined aortic dilatation alone did not differ significantly by karyotype. These findings support karyotype-aware cardiovascular surveillance, while underscoring the need for cautious interpretation of small TTE differences and validation in multicenter longitudinal studies. CI - (c) 2026. The Author(s). FAU - Huang, Yinchun AU - Huang Y AD - Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Luo, Song AU - Luo S AD - Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Qi, Yiying AU - Qi Y AD - Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Qin, Shuang AU - Qin S AD - Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Yue, Chaomin AU - Yue C AD - Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Lu, Qinsheng AU - Lu Q AD - Division of Uterine Vascular Biology, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Lash, Gendie E AU - Lash GE AD - Division of Uterine Vascular Biology, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. FAU - Li, Li AU - Li L AUID- ORCID: 0000-0001-8832-0575 AD - Department of Obstetrics and Gynecology, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Jin Sui Road 9, Guangzhou, Guangdong Province, 510623, China. lilyli1973@126.com. LA - eng GR - 2023A1515010216/Science Fund for Distinguished Young Scholars of Guangdong Province/ GR - 2022B1515120074/Basic and Applied Basic Research Foundation of Guangdong Province/ GR - 2024A03J1175/Guangzhou Science, Technology and Innovation Commission/ PT - Journal Article DEP - 20260620 PL - England TA - Orphanet J Rare Dis JT - Orphanet journal of rare diseases JID - 101266602 SB - IM MH - Humans MH - *Turner Syndrome/genetics/metabolism/diagnostic imaging MH - Female MH - Retrospective Studies MH - Echocardiography/methods MH - Cross-Sectional Studies MH - Adolescent MH - Karyotype MH - Child MH - Cardiovascular Diseases/genetics/metabolism MH - Karyotyping PMC - PMC13563905 OTO - NOTNLM OT - 45,X OT - Aortic size index OT - Cardiovascular disease OT - Dyslipidemia OT - Echocardiography OT - Karyotype OT - Mosaicism OT - Turner syndrome COIS- Declarations. Ethics approval and consent to participate: The study protocol was reviewed and approved by the Scientific Research Ethics Committee of Guangzhou Women and Children's Medical Center, Guangzhou Medical University (approval No. Sui Fu Er Ke Lun Pi Zi [2025] No. 261A01; approval date: 14 August 2025). Informed consent was obtained from participants and/or their legal guardians in accordance with the approved protocol. All data were analyzed in aggregate form without identifying individual participants. Consent for publication: Informed consent for the publication of data was obtained from all participants or their legal caregivers. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/06/21 22:34 MHDA- 2026/09/11 05:36 PMCR- 2026/06/20 CRDT- 2026/06/20 23:27 PHST- 2025/12/24 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/09/11 05:36 [medline] PHST- 2026/06/21 22:34 [pubmed] PHST- 2026/06/20 23:27 [entrez] PHST- 2026/06/20 00:00 [pmc-release] AID - 10.1186/s13023-026-04457-5 [pii] AID - 4457 [pii] AID - 10.1186/s13023-026-04457-5 [doi] PST - epublish SO - Orphanet J Rare Dis. 2026 Jun 20;21(1):315. doi: 10.1186/s13023-026-04457-5. PMID- 42323577 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260917 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 20 TI - Evaluability and feasibility of an intervention combining gaming and social activities to improve mental wellbeing and health behaviour in adolescents facing social challenges. LID - 10.1186/s12887-026-07172-z [doi] LID - 821 AB - BACKGROUND: Adolescents in Denmark increasingly report poor mental wellbeing and health behaviour. Additionally, they spend less time being physically active and being with friends and more time on gaming and social media. The eHOOD intervention was developed to address physical and mental wellbeing of adolescents in vulnerable positions using their motivation for gaming to engage them in a community entailing physical and social activity, and education with peers. This study aimed to assess the evaluability of the eHOOD intervention, to develop an evaluation design, and to test the feasibility and acceptability of the evaluation design and the intervention. METHODS: Evaluability assessment was performed by a working group in a series of workshop-style meetings involving a literature review, creation of a theory of change, and preparation of an evaluation plan including outcome measures, instruments, and data collection procedures. Subsequently the evaluation design and the intervention were tested in a single arm feasibility study. Participants were 13 adolescents aged 13-16 years. The participants met with a coach and a local pedagogue in an after-school club four hours a week for 25 weeks practicing gaming, engaging in physical and social activities, and learning about healthy lifestyle habits through education and communal cooking and dining. Feasibility and acceptability of outcome measures, instruments, and data collection procedures were assessed, and initial changes in outcome measures were measured. Recruitment and retainment of participants were monitored, and participants' motivation for and benefits of participating were explored. Data were collected with qualitative and quantitative methods. RESULTS: An evaluation plan was developed and found to be suitable for use in the subsequent feasibility study. The evaluation design was overall feasible and acceptable, although several important adjustments to measurements and data collection procedures were identified. Initial changes in wellbeing were observed and the World Health Organization-Five Well-Being Index (WHO-5) was deemed relevant as a primary outcome in future evaluation. The intervention was found feasible and acceptable among participants in the present format. CONCLUSIONS: This combined evaluability assessment and feasibility study suggests that the eHOOD intervention is ready for larger-scale evaluation, although refinements to outcome measures and data collection procedures are warranted before effectiveness can be evaluated. TRIAL REGISTRATION: ClinicalTrials.gov, March 23, 2026. Identifier NCT07489365. Retrospectively registered. CI - (c) 2026. The Author(s). FAU - Grew, Julie Christina AU - Grew JC AUID- ORCID: 0000-0001-5770-9174 AD - Center for Clinical Research and Prevention, Copenhagen University Hospital - Frederiksberg, Nordre Fasanvej 57, Hovedvejen 5, Frederiksberg, 2000, Denmark. julie.grew@regionh.dk. FAU - Gotzsche, Nina AU - Gotzsche N AD - Center for Clinical Research and Prevention, Copenhagen University Hospital - Frederiksberg, Nordre Fasanvej 57, Hovedvejen 5, Frederiksberg, 2000, Denmark. FAU - Broberg, Lotte AU - Broberg L AD - Center for Clinical Research and Prevention, Copenhagen University Hospital - Frederiksberg, Nordre Fasanvej 57, Hovedvejen 5, Frederiksberg, 2000, Denmark. AD - Department of Gynecology and Obstetrics, Slagelse Hospital, Faelledvej 14, Slagelse, 4200, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, 2200, Denmark. FAU - Schiotz, Michaela Louise AU - Schiotz ML AD - Center for Clinical Research and Prevention, Copenhagen University Hospital - Frederiksberg, Nordre Fasanvej 57, Hovedvejen 5, Frederiksberg, 2000, Denmark. AD - Department of Public Health, University of Southern Denmark, Campusvej 55, Odense M, 5230, Denmark. LA - eng SI - ClinicalTrials.gov/NCT07489365 PT - Clinical Trial PT - Journal Article DEP - 20260620 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - *Adolescent Behavior/psychology MH - Denmark MH - Exercise/psychology MH - Feasibility Studies MH - *Health Behavior MH - *Health Promotion/methods MH - *Mental Health MH - Motivation MH - Program Evaluation MH - Psychological Well-Being MH - *Video Games/psychology PMC - PMC13536880 OTO - NOTNLM OT - Acceptability OT - Adolescents OT - Evaluability assessment OT - Evaluation design OT - Feasibility OT - Gaming OT - Loneliness OT - Mental wellbeing OT - Physical activity OT - Social activity COIS- Declarations. Ethics approval and consent to participate: The Danish Data Protection Agency assessed the study and categorized it as a quality improvement project, of which registration is redundant. The Regional Health Research Ethics Committees in the Capital Region of Denmark waived the need for ethical approval of the project (ref. no.: F-25073292). Informed consent to participate was obtained from the parents of the participants who were under the age of 16. One participant was 16 years old and, therefore, gave written informed consent herself. The study was performed in accordance with the Declaration of Helsinki. All data were handled in accordance with the GDPR. The study was retrospectively registered at ClinicalTrials.gov (NCT07489365) on March 23, 2026. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/21 22:33 MHDA- 2026/09/02 05:36 PMCR- 2026/06/20 CRDT- 2026/06/20 23:24 PHST- 2026/03/30 00:00 [received] PHST- 2026/06/11 00:00 [accepted] PHST- 2026/09/02 05:36 [medline] PHST- 2026/06/21 22:33 [pubmed] PHST- 2026/06/20 23:24 [entrez] PHST- 2026/06/20 00:00 [pmc-release] AID - 10.1186/s12887-026-07172-z [pii] AID - 7172 [pii] AID - 10.1186/s12887-026-07172-z [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 20;26(1):821. doi: 10.1186/s12887-026-07172-z. PMID- 42322788 OWN - NLM STAT- MEDLINE DCOM- 20260808 LR - 20260808 IS - 1872-8421 (Electronic) IS - 0165-5728 (Linking) VI - 419 DP - 2026 Oct TI - Brain volumetric changes in pediatric seronegative autoimmune encephalitis: A case-control study. PG - 579009 LID - S0165-5728(26)00158-X [pii] LID - 10.1016/j.jneuroim.2026.579009 [doi] AB - Seronegative autoimmune encephalitis (SNAE) is an increasingly recognized entity in pediatric neurology, yet quantitative neuroimaging data remain scarce. This study aimed to evaluate regional brain volumetric differences between children diagnosed with SNAE and age- and sex-matched healthy controls using automated MRI volumetry. Fifteen children with SNAE (median age 12 years; 9 males, 6 females) and 45 age- and sex-matched healthy controls were enrolled. Three-dimensional T1-weighted MRI data were processed using the volBrain automated brain volumetry pipeline. Whole brain, grey matter, white matter, and subcortical structure volumes (thalamus, putamen, caudate, pallidum, hippocampus, amygdala, cerebellum, and brainstem) were compared between groups. Receiver operating characteristic (ROC) curve analysis was performed to determine the discriminative value of significantly different volumetric parameters. Patients with SNAE demonstrated significantly lower absolute grey matter, thalamus, putamen, and pallidum volumes compared with healthy controls after Bonferroni correction. Following ICV-normalization, only putamen and pallidum volumes remained significantly reduced in the patient group. ROC analyses demonstrated significant discriminative performance for several volumetric parameters, with putamen showing the numerically highest AUROC among absolute volumetric measures (AUROC = 0.875) and pallidum showing the highest AUROC among ICV-normalized measures (AUROC = 0.769). Pairwise DeLong comparisons revealed that the ROC performances of these parameters were statistically indistinguishable within this sample. Automated brain volumetry may provide quantitative information complementary to conventional MRI evaluation in pediatric SNAE. Larger prospective studies are needed to validate the clinical significance of these findings. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Deniz, Adnan AU - Deniz A AD - Department of Pediatric Neurology, Kocaeli City Hospital, Kocaeli, Turkiye. Electronic address: adnandeniz85@hotmail.com. FAU - Ozer, Torehan AU - Ozer T AD - Department of Radiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkiye. FAU - Balci, Sibel AU - Balci S AD - Department of Biostatistics, Faculty of Medicine, Marmara University, Istanbul, Turkiye. FAU - Gunes, Ayfer Sakarya AU - Gunes AS AD - Department of Pediatric Neurology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkiye. FAU - Orgun, Leman Tekin AU - Orgun LT AD - Department of Pediatric Neurology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkiye. FAU - Anik, Yonca AU - Anik Y AD - Department of Radiology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkiye. FAU - Kara, Bulent AU - Kara B AD - Department of Pediatric Neurology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkiye. LA - eng PT - Journal Article DEP - 20260619 PL - Netherlands TA - J Neuroimmunol JT - Journal of neuroimmunology JID - 8109498 RN - Hashimoto's encephalitis SB - IM MH - Humans MH - Female MH - Child MH - Male MH - *Brain/diagnostic imaging/pathology MH - Case-Control Studies MH - Magnetic Resonance Imaging/methods MH - Adolescent MH - *Encephalitis/diagnostic imaging/pathology/blood MH - Organ Size MH - *Hashimoto Disease/diagnostic imaging/pathology OTO - NOTNLM OT - Brain volumetry OT - Cerebellum OT - MRI OT - Pediatric OT - Putamen OT - Seronegative autoimmune encephalitis OT - Subcortical structures COIS- Declaration of competing interest The authors declare that they have no competing interests. EDAT- 2026/06/21 22:38 MHDA- 2026/08/09 00:43 CRDT- 2026/06/20 18:04 PHST- 2026/03/30 00:00 [received] PHST- 2026/06/13 00:00 [revised] PHST- 2026/06/19 00:00 [accepted] PHST- 2026/08/09 00:43 [medline] PHST- 2026/06/21 22:38 [pubmed] PHST- 2026/06/20 18:04 [entrez] AID - S0165-5728(26)00158-X [pii] AID - 10.1016/j.jneuroim.2026.579009 [doi] PST - ppublish SO - J Neuroimmunol. 2026 Oct;419:579009. doi: 10.1016/j.jneuroim.2026.579009. Epub 2026 Jun 19. PMID- 42322639 OWN - NLM STAT- MEDLINE DCOM- 20260620 LR - 20260620 IS - 1464-3502 (Electronic) IS - 0735-0414 (Linking) VI - 61 IP - 4 DP - 2026 May 13 TI - Interpretable machine learning for rare events: an inverse probability weighted application to understanding glucagon-like peptide-1 receptor agonists use and incident alcohol-related disorder. LID - agag045 [pii] LID - 10.1093/alcalc/agag045 [doi] AB - OBJECTIVE: Large administrative datasets enable investigation of rare outcomes, but accurate individual-level prediction remains challenging. Emerging evidence suggests that glucagon-like peptide-1 receptor agonists (GLP-1 RAs), used to treat diabetes and obesity, may reduce alcohol craving and intake. We examined predictors of incident alcohol-related disorder (ARD) using inverse probability-weighted (IPW) machine learning models, focusing on GLP-1 RA use. METHODS: We conducted a retrospective cohort study using the MarketScan Multi-State Medicaid Database (N = 96 460). Type 2 diabetic adults aged 18-64 years with GLP-1 RA prescription coverage (2022-2023) and no ARD in 2022 were included. Baseline variables included demographics, social risk factors (Z-codes), comorbidities, insurance characteristics, and GLP-1 RA use. Propensity scores were used to derive stabilized IPW weights to adjust for confounding in GLP-1 RA exposure. An Extreme Gradient Boosting model with IPW was trained using a 70/30 train-test split with five-fold cross-validation and probability calibration. Performance was evaluated using Area Under the Receiver Operating Characteristics Curve (AUROC), recall, and precision. Model interpretability was assessed using SHapley Additive exPlanations (SHAP). RESULTS: GLP-1 RAs were used by 21.7% of individuals; 2.1% (N = 2004) developed incident ARD. The model demonstrated modest discrimination (AUROC = 0.67). Recall and precision were 0.28 and 0.05, respectively. SHAP analysis ranked GLP-1 RA use as the sixth most influential predictor and showed an association with lower predicted ARD risk. CONCLUSION: Predicting rare outcomes remains difficult, particularly for identifying positive cases. Interpretable machine learning identified GLP-1 RA use as an important feature associated with lower predicted ARD risk, warranting further investigation. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Medical Council on Alcohol and Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Gautam, Rinoj AU - Gautam R AD - College of Pharmacy, UNT Health, Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, United States. FAU - Wang, Hao AU - Wang H AUID- ORCID: 0000-0002-5105-0951 AD - Department of Emergency Medicine, JPS Health Network, 1500 S. Main St., Fort Worth, TX 76104, United States. FAU - Zhou, Bo AU - Zhou B AD - College of Pharmacy, UNT Health, Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, United States. FAU - Neba, Rolake AU - Neba R AD - College of Pharmacy, UNT Health, Fort Worth, 3500 Camp Bowie Blvd, Fort Worth, TX 76107, United States. FAU - Sambamoorthi, Usha AU - Sambamoorthi U AD - Health Outcomes Research and AI Innovation, Department of Pharmacy Practice, School of Pharmacy, Temple University, 1801 N. Broad St., Philadelphia, PA 19140, United States. LA - eng GR - 5S21MD012472-05/National Institute on Minority Health and Health Disparities through the Texas Center for Health Disparities (NIMHD)/ GR - 1OT2OD032581-01/National Institutes of Health/Artificial Intelligence/Machine Learning Consortium to Advance Health Equity and Researcher Diversity/ PT - Journal Article PL - England TA - Alcohol Alcohol JT - Alcohol and alcoholism (Oxford, Oxfordshire) JID - 8310684 RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) SB - IM MH - Humans MH - *Glucagon-Like Peptide-1 Receptor Agonists MH - *Machine Learning MH - Retrospective Studies MH - Female MH - Adult MH - Middle Aged MH - Male MH - Predictive Learning Models MH - *Diabetes Mellitus, Type 2/drug therapy MH - *Alcohol-Related Disorders/epidemiology MH - Young Adult MH - United States/epidemiology MH - Adolescent MH - Prediction Algorithms MH - Probability MH - Boosting Machine Learning Algorithms OTO - NOTNLM OT - GLP-1 receptor agonists OT - Medicaid OT - alcohol-related disorder OT - inverse probability weighting OT - machine learning EDAT- 2026/06/21 22:34 MHDA- 2026/06/21 22:35 CRDT- 2026/06/20 14:33 PHST- 2026/03/17 00:00 [received] PHST- 2026/05/14 00:00 [revised] PHST- 2026/05/16 00:00 [accepted] PHST- 2026/06/21 22:35 [medline] PHST- 2026/06/21 22:34 [pubmed] PHST- 2026/06/20 14:33 [entrez] AID - 8712561 [pii] AID - 10.1093/alcalc/agag045 [doi] PST - ppublish SO - Alcohol Alcohol. 2026 May 13;61(4):agag045. doi: 10.1093/alcalc/agag045. PMID- 42322204 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20261016 IS - 1536-4844 (Electronic) IS - 1078-0998 (Print) IS - 1078-0998 (Linking) VI - 32 IP - 8 DP - 2026 Aug 1 TI - Modified Crohn's Disease Exclusion Diet and exclusive enteral nutrition (EEN) resolve oral dysbiosis in pediatric Crohn's disease: a prospective cohort study. PG - 1587-1599 LID - 10.1093/ibd/izag107 [doi] AB - BACKGROUND AND AIMS: Changes to the oral microbiome have been reported in patients with Crohn's disease (CD). The aim of this study was to determine the characteristics and dynamics of the oral microbiome in children randomized to 1 of 2 nutritional treatments for CD. METHODS: Participants (n = 54) in this randomized controlled trial (NCT02843100) received the Crohn's Disease Exclusion Diet (CDED) with either partial enteral nutrition (PEN; n = 28) or exclusive enteral nutrition (EEN; n = 26). The oral microbiome was assessed via swabs from the dorsum of the tongue and the buccal gingiva by 16S rRNA sequencing at 0, 2, 8, 14, 24, and 52 weeks. RESULTS: There were no significant differences in primary or clinical outcomes between the 2 groups. Due to the COVID-19 pandemic, sampling by 24 weeks was limited to 34 participants. At week 0, moderate-severe disease activity (Pediatric Crohn's Disease Activity Index [PCDAI] > 30) was associated with decreased Porphyromonas, Haemophilus, Alloprevotella, Neisseria, and Bergeyella species and increased Actinomyces. As patients entered remission (PCDAI < 10), we observed a restoration in the abundance of these taxa. A modified oral dysbiosis index (MODI) was generated, capable of distinguishing mild from moderate-severe disease activity based on microbiome profiles. Dysbiosis decreased as treatment continued and patients entered remission. Patients on CDED exhibited more significant dysbiosis index changes at weeks 8-24, compared with the EEN group. Application of the index across published oral microbiome data sets validated its ability to discriminate health from CD. CONCLUSION: Oral microbiome changes in pediatric CD reflect disease activity and parallel therapeutic response to CDED and EEN over time. Additional validation of the proposed dysbiosis index should be undertaken in adequately powered future studies. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. FAU - Moran, Gary P AU - Moran GP AUID- ORCID: 0000-0003-0469-1788 AD - School of Dental Science, Trinity College Dublin and Dublin Dental University Hospital, Dublin D02 F859, Ireland. FAU - McQuillan, Adam AU - McQuillan A AD - School of Dental Science, Trinity College Dublin and Dublin Dental University Hospital, Dublin D02 F859, Ireland. FAU - Ho, Gwo-Tzer AU - Ho GT AUID- ORCID: 0000-0002-6014-372X AD - School of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, United Kingdom. FAU - Whelan, Robert J AU - Whelan RJ AD - School of Infection and Immunity, University of Glasgow, Glasgow G12 8TA, United Kingdom. FAU - Navas-Lopez, Victor Manuel AU - Navas-Lopez VM AD - Pediatric Gastroenterology and Nutrition Unit, Hospital Regional Universitario de Malaga, Biomedical Research Institute of Malaga (IBIMA), Malaga 29590, Spain. FAU - Lawrence, Sally AU - Lawrence S AD - Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, British Columbia Children's Hospital, University of British Columbia, Vancouver, BC V6H 3V4, Canada. FAU - Rolandsdotter, Helena AU - Rolandsdotter H AD - Department of Clinical Science and Education, Sodersjukhuset, Karolinska Institutet, 171 77 Stockholm, Sweden. AD - Department of Gastroenterology, Sachs' Children and Youth Hospital, Sodersjukhuset, 118 83 Stockholm, Sweden. FAU - Olen, Ola AU - Olen O AD - Department of Gastroenterology, Sachs' Children and Youth Hospital, Sodersjukhuset, 118 83 Stockholm, Sweden. AD - Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, 171 77 Stockholm, Sweden. FAU - Martin-de-Carpi, Javier AU - Martin-de-Carpi J AD - Department of Pediatric Gastroenterology, Hepatology and Nutrition, Sant Joan de Deu Barcelona, 08950 Barcelona, Spain. FAU - Sigall Boneh, Rotem AU - Sigall Boneh R AD - Pediatric Gastroenterology and Nutrition Unit, The E. Wolfson Medical Center, Holon, 58100, Israel. FAU - Wine, Eytan AU - Wine E AD - Department of Pediatrics, University of Alberta, Edmonton, AB T6G 1C9, Canada. AD - Department of Physiology, University of Alberta, Edmonton, AB T6G 1C9, Canada. AD - Division of Gastroenterology, Hepatology and Nutrition, Hospital for Sick Children, Toronto M5G 1X8, Canada. FAU - Hussey, Seamus AU - Hussey S AD - Department of Paediatrics, University of Medicine and Health Sciences, RCSI Dublin and University College Dublin D02 YN77, Ireland. AD - DOCHAS Group, Children's Health Ireland, Dublin D12 N512, Ireland. LA - eng GR - c/18/2/Children's Health Foundation/ GR - NCRC c/18/2/Children's Health Foundation, Dublin, Ireland/ PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Inflamm Bowel Dis JT - Inflammatory bowel diseases JID - 9508162 RN - Pediatric Crohn's disease SB - IM CIN - Inflamm Bowel Dis. 2026 Sep 1;32(9):1864-1865. doi: 10.1093/ibd/izag149. PMID: 42520306 MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Crohn Disease/microbiology/diet therapy/therapy MH - *Dysbiosis/microbiology/therapy/etiology MH - *Enteral Nutrition/methods MH - Microbiota MH - *Mouth/microbiology MH - Prospective Studies PMC - PMC13414547 OTO - NOTNLM OT - Crohn's Disease Exclusion Diet OT - Crohn's disease OT - exclusive enteral nutrition OT - oral microbiome OT - pediatric COIS- The following authors declare these potential conflicts of interest: S.H.-Research grant from Takeda and Janssen in the past 3 years. No conflict for this study. V.M.N.-L.-Consultation fee, research grant, royalties, or honorarium from Ordesa, Adacyte, Nutricia, Pfizer, AbbVie, Takeda, and Nestle Health Science. S.L.-Educational fees from Takeda and McKesson outside the submitted work. H.J.R.-Nutricia, Semper and Adacyte for research support and speaker fee. None of those have any relation to the present study. A.O.-Research support and advisory board for AbbVie, research site for AbbVie, Janssen, Pfizer, Eli Lilly. F.J.M.C.-Honoraria for talks and advisory from Abbvie, Nestle Health Science, MSD, Adacyte, Janssen. O.O.-Dr. Olen has been PI on projects at Karolinska Institutet financed by grants from Janssen, Takeda, AbbVie, Pfizer, Bristol Myers Squibb, and Ferring, and also report grants from Pfizer, AbbVie, Galapagos, and Janssen in the context of national safety monitoring programs. None of those studies have any relation to the present study. J.V.L.-Nestle Health Sciences consulting/research support/speaker fee and Janssen (Research Support/Travel). R.S.B.-Received funds for consulting or speaker-from Nestle Health Science, Takeda, Megapharm and Janssen; serves on advisory board for Evinature. E.W.-Advisory board: AbbVie, Nestle Health Science, Pfizer, BioJamp; Speaker: AbbVie, Nestle Health Science, Janssen, Mead Johnson Nutrition. G.P.M., A.McQ., G.H., and R.J.W., no conflicts to declare. EDAT- 2026/06/21 22:36 MHDA- 2026/07/30 00:38 PMCR- 2026/06/20 CRDT- 2026/06/20 06:52 PHST- 2025/12/15 00:00 [received] PHST- 2026/05/09 00:00 [accepted] PHST- 2026/07/30 00:38 [medline] PHST- 2026/06/21 22:36 [pubmed] PHST- 2026/06/20 06:52 [entrez] PHST- 2026/06/20 00:00 [pmc-release] AID - 8712085 [pii] AID - izag107 [pii] AID - 10.1093/ibd/izag107 [doi] PST - ppublish SO - Inflamm Bowel Dis. 2026 Aug 1;32(8):1587-1599. doi: 10.1093/ibd/izag107. PMID- 42475469 STAT- Publisher CTDT- 20260620 PB - StatPearls Publishing DP - 2026 Jan TI - Personality Theories. BTI - StatPearls AB - Personality refers to the individual differences and a unique set of traits and characteristics that influence patterns of thinking, feeling, and behaving across various situations and over time. Personality encompasses the unique and relatively stable ways in which people react to situations and interact with others. The core aspects of personality highlight consistency, individual differences, and the interplay of mental and emotional processes. Understanding personality is crucial because this knowledge helps clinicians predict behaviors, improve interpersonal relationships, and foster personal growth. In clinical settings, knowledge of personality theories aids mental health professionals in diagnosing, conceptualizing, and treating mental disorders. For example, therapeutic approaches are tailored to the patient's personality structure. In organizational settings, personality assessments help with employee selection, leadership development, and team building. The study of personality has evolved over centuries, beginning with ancient philosophies and advancing through significant theories developed in the 20th and 21st centuries. Early thoughts on personality can be traced back to Hippocrates' theory of the 4 humors. The modern study of personality began with Freud's psychoanalytic theory in the late 19th century and has since diversified into various schools of thought, each offering unique insights into human nature and behavior.[Hall CS, Lindzey G.Theories of Personality, 3rd ed. John Wiley & Sons, 1978]. Major theoretical frameworks include psychodynamic, trait, humanistic, behavioral, cognitive-social, and biological perspectives. These frameworks differ in their assumptions about the origins, structure, and development of personality, offering diverse yet complementary views that are useful in both research and clinical contexts. Additionally, contemporary formulation models, such as the Five-Factor Model (FFM) and integrative biopsychosocial approaches, have provided empirically grounded tools to link personality traits, psychological variables, and physiological variables in clinical formulations. Major Approaches to Personality Psychoanalytic and psychodynamic theories Psychoanalytic and psychodynamic theories of personality emphasize the influence of unconscious processes and childhood experiences on behavior and personality development. Sigmund Freud was the first to develop a theory of personality, which he called the psychosexual theory of development. Subsequently, psychoanalysts known as Neo-Freudians expanded upon Freud's theory or diverted from it altogether. Major Neo-Freudian theorists include Carl Jung, Alfred Adler, and Erik Erikson. Sigmund Freud, the father of psychoanalysis, proposed that personality consists of 3 interacting components: the id, ego, and superego, in his book [Freud S. The Ego and the Id]. W.W. Norton and Company; 1961] Freud's model explains how internal conflicts and unconscious forces shape personality. Instinctual desires drive the id and operate on the pleasure principle, seeking immediate gratification. The superego represents internalized societal norms and moral standards, striving for ideal behavior. The ego, guided by the reality principle, mediates between the id's impulses and external reality. The ego also employs defense mechanisms to handle anxiety. These unconscious psychological strategies are used to manage anxiety, internal conflict, and threats to self-esteem by distorting or denying reality. The following are several key defense mechanisms proposed by Freud: Repression: Blocking distressing thoughts from conscious awareness (eg, a person who experienced childhood trauma may be unable to recall the event). Denial: Refusing to accept reality or facts that are too threatening (eg, a person with a substance use disorder insisting they do not have a problem). Projection: Attributing one's own unacceptable thoughts or feelings to someone else (eg, a person who is angry at their coworker accuses the coworker of being hostile toward them). Displacement: Redirecting emotions from a threatening target to a safer substitute (eg, yelling at a partner after a frustrating day at work). Rationalization: Creating logical explanations to justify unacceptable behavior (eg, a student blames a poor grade on the teacher disliking them rather than their own lack of preparation). Reaction formation: Behaving in a way that is opposite to one's true feelings (eg, treating someone you dislike with excessive friendliness). Sublimation: Channeling unacceptable impulses into socially acceptable activities (eg, redirecting aggressive impulses into sports or creative work). Regression: Reverting to behaviors characteristic of an earlier developmental stage (eg, an overwhelmed adult throwing a temper tantrum or seeking comfort in childish routines). Freud noted these mechanisms can be adaptive or maladaptive depending on their context and intensity. While these mechanisms serve to shield individuals from guilt and anxiety, they may also alter one's perception of reality in a disruptive manner, potentially leading to maladaptive behavior. Freud's theory also includes 5 stages of psychosexual development-oral, anal, phallic, latency, and genital-that he believed are crucial for personality formation. [Freud S. Three Essays on the Theory of Sexuality. Hogarth Press; 1962]. Each stage is associated with a specific erogenous zone and psychological conflict that must be resolved for healthy development: 1. The oral stage (birth to approximately 18 months) centers on the mouth, with sucking and feeding as primary activities; dependency, trust, and oral gratification are dominant, and fixation may lead to traits such as passivity, dependency, or oral habits like smoking. 2. The anal stage (18 months to approximately 3 years ) involves the anus and the control of bowel movements; conflicts here relate to autonomy and self-control, with fixation potentially resulting in either excessive orderliness (anal-retentive) or messiness (anal-expulsive). 3. The phallic stage (approximately 3 to 6 years) focuses on the genitals and the resolution of the Oedipus or Electra complex, where children develop unconscious desires for the parent of the opposite sex and rivalries with the parent of the same sex; successful resolution leads to identification with the same-sex parent and development of the superego. 4. The latency stage (6 years to puberty) is marked by the sublimation of sexual impulses into socially acceptable activities like school, friendships, and hobbies. This stage is a period of relative psychological calm and ego development. 5. The genital stage (puberty onward) indicates the return of sexual impulses, now directed toward appropriate others outside the family; successful navigation results in mature sexual identity and the capacity for healthy adult relationships. Freud posited that fixation at any of these stages could result in enduring behavioral patterns or personality traits, highlighting his view that early developmental conflicts deeply shape adult personality. This perspective underscores a foundational premise in psychoanalytic theory, that unconscious processes and childhood experiences play a critical role in the formation and structure of personality. Neo-Freudians, expanding on Freud's ideas, began to emphasize social and cultural factors as central to personality development. For example, Carl Jung's analytical psychology introduced influential concepts such as the collective unconscious and archetypes. The collective unconscious refers to the shared, inherited reservoir of memories, archetypes, and instincts that influence human thoughts and behaviors, existing beyond individual experience. Archetypes represent universal, inherited patterns or symbols residing in the unconscious mind that guide human thoughts, emotions, and behaviors.[Jung CG. Man and His Symbols. Doubleday; 1964]. These archetypes include: The Self: representing wholeness and unity. The Shadow: one's darker, unconscious aspects. The Anima/Animus: the feminine side of men and the masculine side of women. The Persona: the social mask one presents to the world. Jung stressed the importance of achieving individuation, a lifelong process of integrating the conscious and unconscious aspects of the self to achieve psychological wholeness. Jung also emphasized the balance between opposing forces within the psyche, such as the Persona and the Shadow, or the thinking and the feeling functions.[Jung CG. Man and His Symbols. Doubleday; 1964]. His typology of introversion and extraversion, along with his theory of psychological functions, laid the groundwork for modern personality typologies, including the Myers-Briggs Type Indicator (MBTI), which categorizes individuals based on 4 dichotomies derived from Jung's work: Introversion-Extraversion. Sensing-Intuition. Thinking-Feeling. Judging-Perceiving [Myers IB, McCaulley MH, Quek NL, Hammer AL. MBTI Manual: A Guide to the Development and Use of the Myers-Briggs Type Indicator. 3rd ed. Consulting Psychologists Press; 1998]. Jung believed that personality continues to evolve throughout life and is deeply shaped by symbolic, spiritual, and cultural experiences, emphasizing a dynamic and developmental view of personality that contrasts with more static trait-based models.[Jung CG. Man and His Symbols. Doubleday; 1964]. His perspective broadened the scope of personality theory by incorporating unconscious processes, lifelong growth, and the influence of archetypal and cultural forces on individual identity. Conversely, Alfred Adler's individual psychology theory emphasized the inherently social nature of human beings and the drive for superiority as a key motivator of behavior. Adler introduced the concept of social interest (gemeinschaftsgefuhl), referring to an individual's sense of belonging and contribution to the welfare of others, as a core element of psychological health.[Adler A. The Science of Living. George Allen & Unwin Ltd; 1930] Adler posited that personality is largely shaped by how individuals strive to overcome feelings of inferiority, which often originate in childhood experiences of helplessness or inadequacy. The ways individuals compensate for these feelings give rise to unique lifestyles that reflect their attitudes, goals, and coping mechanisms. Adler's concept of the inferiority complex remains relevant in contemporary psychology, offering insights into self-esteem, regulation, motivation, and interpersonal dynamics. By emphasizing purposeful striving, social embeddedness, and the formation of unique life patterns, Adler's theory contributes a goal-directed and socially anchored framework to the broader landscape of personality theory. Erik Erikson's psychosocial development theory proposed 8 stages of psychosocial development, each characterized by a specific conflict that contributes to personality. Unlike Freud, Erikson emphasized social and environmental factors and extended his theory into adulthood. Each stage presents a psychosocial crisis that must be resolved for adaptive psychological functioning.[Erikson EH. Childhood and Society. Norton; 1950]. The stages are as follows: 1. Trust vs mistrust (infancy, or 0 to 1 year): Developing secure attachments fosters a sense of safety and reliability in the world. 2. Autonomy vs shame and doubt: (early childhood, 1 to 3 years): Developing personal control and independence. 3. Initiative vs guilt (preschool, 3 to 6 years): During this stage, children begin to assert control and initiative in social and play situations. 4. Industry vs inferiority (school age, 6 to 12 years): Emphasizing competence and achievement through mastery of tasks. 5. Identity vs role confusion (adolescence, 12 to 18 years): centering on developing a cohesive personal identity amid changing roles and expectations. 6. Intimacy vs isolation (young adulthood, 18 to 40 years): Forming meaningful, reciprocal relationships. 7. Generativity vs stagnation (middle adulthood, 40 to 65 years): Contributing to society and guiding the next generation. 8. Integrity vs despair (late adulthood, 65 years and older): reflecting on one's life with a sense of fulfillment or regret. Erikson's model underscores the dynamic and lifelong nature of personality development, offering a stage-based framework that accounts for normative transitions, developmental crises, and stress-related maladjustments. Erikson's work expands personality theory by framing personality as a continually evolving process, deeply embedded in social relationships, cultural expectations, and the individual's efforts to resolve key psychological challenges across the lifespan. Psychoanalytic and psychodynamic theories have had a profound influence on the understanding of personality by emphasizing unconscious processes, early developmental experiences, and intrapsychic conflict. Despite criticisms regarding testability and scientific rigor, these theories have provided rich conceptual frameworks that continue to inform clinical practice and research. Concepts such as defense mechanisms, fixation, and unconscious motivation offer enduring value in explaining complex personality patterns and psychopathology. Personality psychology has evolved, and these foundational theories remain essential for appreciating the depth and dynamism of human behavior. Trait theories Trait theories of personality focus on identifying and measuring individual differences in consistent patterns of thoughts, feelings, and behaviors known as traits. Notable trait theorists include Gordon Allport, Raymond Cattell, and Hans Eysenck. These early theorists laid the foundation for the development of the FFM, also known as the Big Five, which organizes personality into 5 broad domains. Trait theories hold that personality traits are relatively stable over time, differ among individuals, and influence behavior across various situations. Consequently, trait theories offer a robust framework for predicting behavioral tendencies, informing clinical assessment, and guiding interventions across diverse life contexts. Gordon Allport's trait theory identified central and secondary traits that define personality, emphasizing the uniqueness of the individual. Central traits are core characteristics that form the foundation of personality, such as honesty, sociability, or optimism, and are consistent across various situations.[Allport GW. Personality: A Psychological Interpretation. Holt; 1937] Secondary traits are more situation-specific and less consistent, such as preferences for particular styles of clothing or tastes in music. Allport also proposed cardinal traits, or dominant traits that can shape nearly all of a person's behavior, though he noted these are rare. For example, a person whose life is strongly defined by altruism or ambition might exhibit a cardinal trait that permeates their thoughts, decisions, and actions. Raymond Cattell's 16 personality factors model used factor analysis to identify 16 basic personality traits, which he believed could predict behavior. Cattell's theory laid the groundwork for later trait theories and emphasized the importance of empirical research in personality psychology. Cattell distinguished between surface traits (observable behaviors) and source traits (underlying structures), arguing that source traits form the building blocks of personality.[Cattell RB. The Description and Measurement of Personality. World Book Company; 1946] The 16 personality factors are: Warmth: The degree of friendliness and affection toward others. Reasoning: Abstract thinking and problem-solving ability. Emotional stability: Calmness and resilience under stress. Dominance: Assertiveness and forcefulness in social situations. Liveliness: Enthusiasm and spontaneity. Rule-consciousness: Adherence to rules and social norms. Social boldness: Comfort with social interactions and risk-taking. Sensitivity: Aesthetic appreciation and emotional responsiveness. Vigilance: Suspicion and tendency to question others' motives. Abstractedness: Preference for imagination and introspective thinking. Privateness: Discretion and reservation in self-disclosure. Apprehension: Self-doubt and insecurity. Openness to change: Flexibility and adaptability to new experiences. Self-reliance: Independence and preference for solitude. Perfectionism: Organization, thoroughness, and desire for precision. Tension: Impatience and high drive or restlessness. These traits offered a more nuanced view of personality structure and provided a foundation for the development of personality assessment tools still in use today. Hans Eysenck's psychoticism, extraversion, neuroticism (PEN) model posited 3 distinct dimensions of personality that he stated have a biological basis and can be measured reliably.[Eysenck HJ. The Biological Basis of Personality. Charles C Thomas; 1967]. These 3 dimensions exist along a continuum, with traits ranging between the following poles: Psychoticism-Normality: The most controversial of the 3, captures traits associated with aggressiveness, impulsivity, creativity, and a lack of empathy. Extraversion-Introversion: Reflects the degree to which individuals are outgoing, energetic, and sociable versus reserved, quiet, and introspective. Neuroticism-Stability: Pertains to emotional reactivity and vulnerability to stress. Eysenck posited that individuals with extraversion have lower baseline levels of cortical arousal, leading them to seek external stimulation. In contrast, individuals with introversion have higher baseline arousal and thus prefer less stimulating environments to maintain optimal functioning. Individuals with high neuroticism tend to experience heightened emotional responses, anxiety, and mood instability, potentially because of greater autonomic nervous system reactivity. Those low in neuroticism-closer to emotional stability-demonstrate greater resilience and calmness in stressful situations. Eysenck theorized that this dimension was linked to dopaminergic activity and shared a potential relationship with vulnerability to certain psychiatric conditions, such as schizophrenia. High scores on psychoticism do not imply clinical psychosis but may reflect a greater disposition toward nonconformity and unconventional thinking. Eysenck's trait theory offered an early biologically informed framework for understanding broad patterns of behavior and temperament. One of the most influential and empirically supported trait theories is the Big Five, also known as the FFM, which provides a comprehensive framework for understanding personality across cultures and life stages.[McCrae RR, Costa PT. The Five-Factor Theory of Personality. In: John OP, Robins RW, eds. Handbook of Personality: Theory and Research. 4th ed. Guilford Press; 2018:79-102] The Big Five factors include: Openness to experience: Creativity and willingness to try new things. Conscientiousness: Organization and dependability. Extraversion: Sociability and assertiveness. Agreeableness: Compassion and cooperativeness. Neuroticism: Tendency toward emotional instability. According to this theory, psychologically healthy individuals typically present with high levels of openness, conscientiousness, extraversion, and agreeableness, along with low levels of neuroticism. The FFM is supported by robust cross-cultural and longitudinal research and has clinical utility in identifying trait vulnerabilities to psychiatric conditions such as mood, anxiety, and personality disorders. Moreover, the FFM's widespread use in both clinical and organizational settings underscores its predictive validity across life domains, offering a reliable structure for assessment, intervention, and personal development. Trait theories contribute a robust empirical framework for identifying and measuring the stable characteristics that differentiate individuals. From Allport's focus on central and secondary traits, to Cattell's data-driven 16-factor model, and Eysenck's biologically grounded dimensions, each theorist has helped shape the understanding of how personality traits operate across time and situations. The development of the FFM has provided a comprehensive and widely accepted taxonomy that has demonstrated predictive validity across clinical, occupational, and interpersonal domains. Trait theories are instrumental in capturing the enduring structure of personality, offering clarity, consistency, and practical utility in both research and applied settings. Humanistic theories Humanistic theories of personality emphasize self-actualization, personal growth, and the intrinsic goodness of individuals, focusing on subjective experience and individual potential. Psychological health, according to humanistic theorists, stems from living authentically and maintaining internal coherence, guided by core values. Carl Rogers, Abraham Maslow, George Kelly, and Rollo May were instrumental in shaping this perspective. Unlike deterministic frameworks such as psychoanalysis or behaviorism, humanistic theories highlight free will, intrinsic motivation, and the ability to make conscious choices in shaping one's life and identity. Carl Rogers' person-centered theory emphasized the self-concept and the need for unconditional positive regard for healthy development. Rogers believed that people are inherently good and capable of self-actualization when provided with the right conditions. The self-concept is an organized, consistent set of perceptions and beliefs about oneself and plays a central role in behavior and mental health. A positive self-concept leads to a healthier personality, while discrepancies between self-perceptions and experiences can lead to psychological concerns. Conditions of worth are expectations placed on oneself for receiving acceptance from others, which can influence self-esteem and personal growth. When individuals perceive conditional love and acceptance, they may distort their true feelings and experiences to meet these conditions. For optimal psychological functioning, Rogers emphasized 3 core conditions in the therapeutic relationship: genuineness (congruence), unconditional positive regard, and accurate empathic understanding. Abraham Maslow's hierarchy of needs ranges from basic physiological needs to self-actualization, where individuals realize their full potential.[Maslow AH. A Theory of Human Motivation. Psychol Rev. 1943;50(4):370-396] He proposed that higher-level needs become relevant only after lower-level needs are satisfied. Self-actualization is the process of fulfilling one's potential and achieving the highest level of human functioning. Self-actualization involves the pursuit of personal growth, creativity, and peak experiences. Maslow's original hierarchy consists of five levels: 1. Physiological needs: Basic survival necessities such as food, water, warmth, and rest. 2. Safety needs: Protection from harm, stability, law and order, and personal security. 3. Love and belongingness needs: Emotional relationships such as friendships, intimacy, and family connections. 4. Esteem needs: Feelings of accomplishment, respect from others, self-respect, and recognition. 5. Self-actualization: The drive to realize one's full potential through personal growth, creativity, and meaning-making. Self-actualization involves the pursuit of peak experiences-profound moments of love, understanding, happiness, or rapture-which contribute to a sense of transcendence and fulfillment. Maslow later introduced a sixth level: 6. **Self-transcendence**: A state in which individuals go beyond their own self-interest to experience unity with something greater, such as altruism, spiritual enlightenment, or service to others Maslow's model remains a cornerstone in understanding motivational influences on personality development and personal meaning across the lifespan. George Kelly's personal construct theory proposed that individuals act as scientists, continuously developing and revising personal constructs-cognitive frameworks for interpreting and predicting experiences.[Kelly GA. The Psychology of Personal Constructs. Vol 1. Norton; 1955] These constructs are binary dimensions (eg, friendly-hostile, competent-incompetent) through which people perceive themselves, others, and the world. According to Kelly, personality is shaped by the unique ways in which individuals organize and apply these constructs, making each person's experience of reality subjective and personal. Because constructs are learned and modifiable, personality is viewed as an open, evolving system, allowing for change and adaptation across the lifespan. This theory underscores the humanistic emphasis on agency and meaning-making, as well as the individual's role in constructing their identity. Rollo May, another key figure in existential-humanistic psychology, emphasized the role of anxiety, choice, and authenticity in personality development.[May R, Existential Psychology. 2nd ed. Random House, 1969] Drawing on existential philosophy, May viewed personality as shaped by how individuals confront fundamental human concerns such as freedom, isolation, meaning, and death. He proposed that healthy personality functioning involves the courage to face existential anxiety and make authentic choices that align with one's values. In contrast, avoidance of these realities can lead to alienation and neurosis. May's concept of the daimonic-the innate force within each person that can be both creative and destructive-reflects his belief in the complexity of the human condition. His work deepened the humanistic emphasis on meaning-making and underscored the moral and existential dimensions of personality. Together, the humanistic theories of Rogers, Maslow, Kelly, and May emphasize the centrality of personal growth, self-awareness, and authenticity in shaping personality. While each theorist offers a distinct framework-ranging from hierarchical needs to existential choice-they all converge on the belief that individuals are inherently motivated to realize their fullest potential. Humanistic theory enriches our understanding of personality by highlighting the subjective, experiential, and aspirational aspects of human nature, positioning personality not as a fixed set of traits but as a dynamic, evolving process of becoming. Behavioral and social cognitive theories Behavioral and social cognitive theories of personality emphasize the role of environmental influences, learning, and cognitive processes in shaping behavior and personality. The most notable behavioral and social cognitive theorists include B.F. Skinner, Albert Bandura, and Julian Rotter. These approaches reject the notion of internal traits or unconscious motives as central explanations, instead prioritizing observable behavior and the context in which it occurs. B.F. Skinner's behaviorism theory emphasized the role of external stimuli in shaping behavior through operant conditioning.[Skinner BF. Science and Human Behavior. Macmillan; 1953] He argued that behavior is determined by its consequences, which can reinforce or diminish specific behaviors. Operant conditioning involves learning through rewards and punishments, reinforcing desired behaviors and discouraging undesirable behaviors. Positive reinforcement increases the likelihood of a behavior by providing a rewarding consequence, while negative reinforcement increases the likelihood of a behavior by removing an aversive stimulus. Conversely, positive punishment decreases the likelihood of a behavior by introducing an aversive consequence, while negative punishment reduces behavior by removing a rewarding stimulus. Skinner maintained that personality is essentially a pattern of learned responses shaped by environmental contingencies over time. He rejected the use of internal mental states, such as motives or traits, as explanatory constructs, arguing instead that observable behavior and environmental conditions are the only valid units of psychological analysis. In this view, personality is the cumulative outcome of an individual's unique reinforcement history, leading to consistent behavior patterns across similar environmental contexts-a radically empirical approach to understanding stable individual differences. Albert Bandura's social learning theory introduced the concept of reciprocal determinism, the idea that behavior, personal factors (ie, cognition, emotions, and biological events), and environmental influences all interact and shape one another. He emphasized the importance of observational learning-learning by watching others-and modeling, which explains how individuals acquire new behaviors by observing the actions and consequences of others. This social-cognitive process not only shapes behavior but also contributes to the formation of enduring personality patterns over time. A central concept in Bandura's theory is self-efficacy, or an individual's belief in their capacity to execute behaviors necessary to produce specific outcomes. High self-efficacy promotes motivation, resilience, and adaptive functioning, whereas low self-efficacy can lead to avoidance, passivity, and psychological distress. Bandura's work bridged the gap between behaviorism and cognitive psychology, highlighting the role of internal cognitive processes such as forethought, self-reflection, and symbolic thinking in shaping behavior. Social learning theory provides a powerful framework for understanding personality as a dynamic and socially embedded system of learned behaviors, cognitive appraisals, and self-regulatory mechanisms. Julian Rotter's social learning theory and locus of control framework describe the degree to which individuals believe they have control over events affecting them. An internal locus of control suggests that individuals believe they can influence outcomes through their own efforts, decisions, and actions. In contrast, an external locus of control indicates a belief that outcomes are determined by external forces such as fate, luck, or powerful others. This concept has broad implications for motivation, decision-making, coping strategies, and psychological resilience. Individuals with a strong internal locus of control tend to take greater responsibility for their behavior, engage in more proactive problem-solving, and exhibit higher levels of achievement orientation and self-efficacy. In contrast, those with an external locus of control may be more prone to passivity, learned helplessness, and maladaptive coping in the face of adversity. Rotter's theory contributes to personality psychology by emphasizing how individuals' perceived control over life events forms a stable cognitive trait that influences behavior, emotional regulation, and interpersonal functioning across time and situations. Behavioral and social cognitive theories collectively underscore the powerful influence of environmental contingencies, learning experiences, and cognitive processes in shaping personality. While behaviorists like Skinner emphasized observable actions and reinforcement histories, theorists such as Bandura and Rotter integrated internal cognitive factors-like beliefs, expectations, and self-perceptions-into the understanding of behavior. Together, these perspectives highlight that personality is not solely an internal construct but a dynamic, context-dependent pattern shaped by the reciprocal interaction of individuals and their environments. Biological, environmental, and evolutionary theories Biological and evolutionary theories of personality focus on the inherent, biological underpinnings and evolutionary roots that shape individual differences in behavior and traits. These approaches emphasize that genetic factors, brain structures, and evolutionary processes play a critical role in the development and manifestation of personality. This perspective integrates findings from genetics, neuroscience, and evolutionary psychology to provide a comprehensive understanding of how biological processes influence personality. Biological perspectives challenge purely environmental or intrapsychic models by positing that personality is, at least in part, biologically encoded. Additionally, environmental factors such as early life experiences, socialization, and cultural background interact with biology to shape personality development across the lifespan. Genetic influences on personality are significant, as evidenced by twin and adoption studies. Results from these studies suggest that many personality traits have a heritable component, affecting factors such as temperament and predispositions. For example, identical twins, who share the same genetic makeup, exhibit more similar personality traits compared to fraternal twins, who share only about half of their genetic variation. This genetic influence underscores the importance of heredity in shaping individual personality differences. However, heritability does not imply immutability; genetic predispositions interact dynamically with environmental conditions to influence outcomes. Strongly heritable traits can be expressed differently depending on life context, stress exposure, and social interactions-reinforcing the need for an integrative biopsychosocial understanding of personality. Neuroscience research highlights the brain's role in personality, indicating that brain structures and functions correlate with various personality traits. Differences in brain activity and anatomy can be linked to specific traits, offering a biological basis for personality. For example, the prefrontal cortex is involved in impulse control and decision-making, while the amygdala is associated with emotional processing and regulation. Individuals with higher levels of activity in the prefrontal cortex tend to exhibit traits such as conscientiousness and self-control. In contrast, those with a more reactive amygdala may display higher levels of neuroticism and emotional sensitivity. These findings highlight the significant role that brain biology plays in shaping our personalities. Moreover, functional connectivity between brain regions, including the default mode and salience networks, is increasingly being studied as a correlate of broader personality dimensions such as openness and extraversion. Findings from neuroimaging studies provide insights into the neural correlates of personality, revealing how brain structure and function are linked to individual differences in behavior. Differences in the volume and activity of the prefrontal cortex, amygdala, and other brain regions have been associated with traits such as impulsivity, emotional regulation, and social behavior. These findings have important implications for understanding the biological bases of personality and for developing treatments for personality disorders. As neuroimaging techniques continue to advance, researchers are uncovering increasingly nuanced associations between neural circuits and complex personality dimensions. Neuroimaging research also offers potential for early identification of risk factors for psychopathology based on stable personality features. Results from ongoing studies continue to refine the understanding of how personality traits develop and interact with environmental factors throughout the lifespan. Specifically, cultural research in personality psychology examines how cultural contexts influence the expression and development of personality traits. Results from these studies have shown that cultural norms and values can shape personality traits and their behavioral manifestations. For example, collectivist cultures often cultivate traits such as agreeableness and conformity, emphasizing group harmony and social cohesion. Understanding these cultural differences is essential for developing culturally sensitive assessment tools and interventions. These insights also underscore the importance of contextualizing personality within broader sociocultural frameworks. In this view, personality is not only a biological construct but a culturally embedded phenomenon that evolves in response to shifting environmental demands and cultural expectations. Lastly, evolutionary perspectives on personality traits explore how certain characteristics may have been advantageous for survival and reproduction. Traits such as sociability, aggression, and altruism are examined through the lens of evolutionary pressures and adaptation. For example, sociability might have been advantageous in forming alliances and gaining social support, while aggression could have played a role in defending resources and ensuring survival. By understanding these evolutionary functions, clinicians and researchers gain insights into why certain traits persist and how they contribute to human behavior. The evolutionary approach provides a long-term, functional perspective on personality development, highlighting how traits may have conferred reproductive or social advantages in ancestral environments. Evolutionary theory also helps explain the universality and cross-cultural stability of core personality dimensions such as extraversion and conscientiousness, which may have historically enhanced fitness in predictable ways. Biological, environmental, and evolutionary theories offer a multidimensional framework for understanding personality by integrating genetic, neurobiological, environmental, cultural, and evolutionary factors. These perspectives emphasize that personality is not solely a product of experience or cognition, but rather the result of dynamic interactions between inherited traits, brain mechanisms, developmental contexts, and adaptive functions. By accounting for both biological constraints and environmental influences, this approach provides a rich and scientifically grounded understanding of how and why individual personality differences emerge and persist across time and cultures. Critique of Personality Theories Each personality theory has its strengths and limitations, offering unique insights but also facing criticisms. Psychoanalytic theories provide deep insights into unconscious processes, such as repressed memories and internal conflicts, which can help explain complex behaviors and psychological disorders.[Freud S. The Ego and the Id. W. W. Norton & Co.; 1961.][Freud S. Three Essays on the Theory of Sexuality. Hogarth Press; 1962.] However, they lack empirical support due to their reliance on subjective interpretation and the difficulty of scientifically testing unconscious phenomena.[Skinner BF. Critique of Psychoanalytic Concepts and Theories. Sci Mon. 1954;79(5):300-305.] Additionally, these theories often overlook the role of social and environmental influences on personality. Psychoanalytic concepts, such as the id, ego, and superego, are difficult to operationalize and test, limiting their utility in empirical research and clinical application. Psychoanalytic theories are also heavily rooted in historical, culturally specific assumptions about human development, which may reduce their generalizability across diverse populations. In contrast, trait theories offer measurable and testable constructs, making it easier to quantify and compare individual differences. The Big Five model, for example, provides a clear and concise framework for understanding personality traits. Despite this, trait theories may oversimplify personality by focusing primarily on stable traits and neglecting the dynamic and situational aspects of behavior. Trait theories also struggle to explain how and why these traits develop over time. Moreover, trait theories do not account for the influence of context or shifting motivations, which can lead to variability in personality expression across situations. Critics further note that trait descriptors tend to describe behavior rather than explain it, offering limited insight into the psychological mechanisms driving personality Humanistic theories emphasize individual potential and personal growth, highlighting the importance of self-actualization and the inherent goodness of people. These theories promote a positive view of human nature and focus on subjective experiences and individual potential. However, humanistic theories are often criticized for lacking scientific rigor and empirical support, because their concepts can be abstract and difficult to measure. While humanistic approaches are valuable in therapeutic settings for fostering empathy and personal insight, their lack of falsifiability poses challenges for systematic investigation. Additionally, critics argue that the emphasis on individual autonomy and self-fulfillment may underrepresent the influence of structural or sociocultural constraints on personality development. Behavioral theories focus on observable behavior and environmental influences, providing a solid foundation for understanding how behavior is learned and maintained through reinforcement and punishment. Behavioral theories are supported by extensive empirical research and practical applications, particularly in behavior modification and therapy. However, behavioral theories may neglect internal processes such as thoughts and emotions, which also play a crucial role in shaping personality. These limitations led to the emergence of cognitive-behavioral approaches, which seek to integrate internal mental processes with behavioral principles. Furthermore, strict behaviorist models have difficulty accounting for spontaneous or novel behavior that arises without a clear reinforcement history. Lastly, biological and evolutionary theories offer a robust framework for understanding the genetic and adaptive bases of personality. These theories emphasize the role of genetic factors, brain structures, and evolutionary processes in shaping behavior. Biological and evolutionary theories provide valuable insights into the biological underpinnings of personality traits, but they can be reductionist, sometimes oversimplifying the complex interplay between biology and environment. Additionally, these theories may not fully account for the influence of cultural and social factors on personality development. Critics also argue that emphasizing innate predispositions can minimize the importance of learning, experience, and personal agency in shaping personality. Moreover, evolutionary explanations can be speculative and difficult to test empirically, raising questions about their scientific falsifiability and application to contemporary psychological challenges. In sum, while each personality theory contributes valuable insights into human behavior and individual differences, none offers a fully comprehensive account on its own. Their strengths lie in their explanatory power within specific domains-whether unconscious motivation, trait measurement, personal growth, learned behavior, or biological mechanisms. However, each theory's limitations underscore the complexity of personality as a construct shaped by multifaceted, interacting influences. A truly integrative understanding of personality must account for the dynamic interplay between biology, environment, cognition, development, culture, and personal agency-highlighting the ongoing need for theoretical integration and empirical refinement in personality psychology. Integration and Synthesis of Theories Modern approaches to personality theory often integrate elements from multiple frameworks to provide a more comprehensive understanding of personality. One prominent example is the biopsychosocial model, which combines biological, psychological, and social factors to explain personality development and behavior. The biopsychosocial model acknowledges the complexity of personality and the interplay among various influences, offering a more holistic perspective. By considering the strengths and limitations of each theory, researchers and clinicians can develop more nuanced and effective interventions to understand and improve human behavior. Additionally, the biopsychosocial model fosters interdisciplinary collaboration, bridging fields such as psychology, neuroscience, sociology, and medicine, and supports tailored approaches to assessment and treatment by recognizing the interplay of internal traits, environmental influences, and contextual variability. The integration of theories is evident in models that incorporate multiple dimensions of personality. For example, the diathesis-stress model integrates biological predispositions (diathesis) with environmental stressors (stress) to explain the onset of psychological disorders. The diathesis-stress model helps in understanding how genetic vulnerabilities interact with life experiences to influence personality and mental health outcomes. Similarly, Bronfenbrenner's ecological systems theory examines how different environmental systems, from immediate family to broader societal influences, interact and shape individual personality development. This perspective highlights how personality does not develop in isolation, but rather within nested contexts that exert simultaneous and cumulative effects, emphasizing developmental timing and context. Building on these perspectives, interactionism challenges traditional trait models by highlighting the significance of within-person variability and person-situation fit in personality expression. Rather than viewing personality as fixed, modern approaches emphasize its dynamic nature, highlighting how behavior emerges from the continuous interplay of genetic and environmental influences. Results from studies demonstrate that factors such as parenting styles, socioeconomic status, and nonshared environmental conditions contribute to individual differences, particularly in internalizing problem behavior. Findings from twin studies further illustrate that, while traits such as extraversion and neuroticism have a genetic basis, environmental influences play a crucial role in their development over time. Recognizing these interactions is essential for developing personalized interventions that account for both genetic and environmental contexts, ensuring that psychological assessments reflect the complexity of human behavior. One example of an integrative framework that reflects this dynamic approach is Mischel's cognitive-affective personality system (CAPS) theory. The CAPS theory proposes that individual responses to situations are influenced by cognitive and affective units, such as competencies, encoding strategies, and self-regulatory plans, which interact with situational contexts to produce behavior. By incorporating trait and social-cognitive perspectives, the CAPS theory provides a structured yet flexible explanation for intraindividual variability and personality consistency. Unlike traditional trait models, the CAPS theory acknowledges the conditional nature of behavior, emphasizing that personality is adaptive and context-sensitive rather than rigidly stable. In doing so, the CAPS theory addresses criticisms of both trait theory and purely behavioral models, highlighting the importance of context in shaping individual behavioral patterns. Integrative approaches to personality theory reflect a growing recognition that no single framework can fully account for the complexity of human behavior. By integrating insights from biological, psychological, and social models, modern theories offer a more nuanced understanding of personality as a dynamic, evolving construct. The synthesis of these theories not only advances theoretical development but also enhances practical applications across clinical, educational, and organizational settings, allowing for more precise personality assessments and interventions. As personality science continues to evolve, integrative models will be essential for capturing the multifaceted nature of individual differences, informing more personalized and effective interventions, and promoting interdisciplinary collaboration. CI - Copyright (c) 2026, StatPearls Publishing LLC. FAU - Gallios, Jacqueline M AU - Gallios JM AD - John Jay College of Criminal Justice FAU - Iyer, Veeraraghavan AU - Iyer V AD - Psychiatry Baystate Medical Center FAU - Kaylor, Leah E AU - Kaylor LE AD - Saint Louis University LA - eng PT - Study Guide PT - Book Chapter PL - Treasure Island (FL) COIS- Disclosure: Jacqueline M Gallios declares no relevant financial relationships with ineligible companies. Disclosure: Veeraraghavan Iyer declares no relevant financial relationships with ineligible companies. Disclosure: Leah E Kaylor declares no relevant financial relationships with ineligible companies. EDAT- 2026/06/20 00:00 CRDT- 2026/06/20 00:00 AID - NBK623739 [bookaccession] PMID- 42321957 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260830 LR - 20260902 IS - 2662-2211 (Electronic) IS - 2662-2211 (Linking) VI - 7 IP - 1 DP - 2026 Jun 19 TI - Roll-Out Implementation Optimization (ROIO) trial to develop and test the implementation of a food security screening and referral process: a study protocol. LID - 10.1186/s43058-026-01025-7 [doi] LID - 171 AB - BACKGROUND: Food insecurity (FI) is associated with poorer physical and mental health outcomes, exacerbation of chronic diseases, and decreased access to healthcare. Children experiencing FI face additional risks, including lower psychosocial functioning and reduced academic achievement. Although national initiatives call for integrating nutrition support services into healthcare, clinical workflows for FI screening and referral remain inconsistently implemented and difficult to sustain. The goal of this study is to refine, adapt, and optimize a comprehensive FI screening and referral program, and identify effective implementation strategies for pediatric healthcare systems. METHODS: We will use a RollOut Implementation and Optimization (ROIO) trial design to iteratively implement and refine the implementation strategies for our FI screening and referral program (I-FRESH: Implementing Food Referrals for Equity and Sustained Health) across 4 pediatric clinics. I-FRESH includes: (1) FI screening; (2) assessment of family needs and readiness to access services; (3) referral and navigation support to community nutrition programs; and (4) follow-up to assess fit, utilization, and ongoing needs. The Pragmatic, Robust Implementation and Sustainability Model (PRISM) will guide adaptation and evaluation of contextual determinants, while RE-AIM will guide assessment of outcomes (implementation feasibility and acceptability, fidelity, adoption, reach, effectiveness, and maintenance). We will identify several implementation strategies to increase the likelihood that I-FRESH can be successfully implemented and sustained in a pediatric healthcare system. We will enroll 240 participants and assess preliminary effectiveness on family‑level food security and pediatric nutrition‑related health outcomes (e.g. weight status, blood pressure, lipids, HbA1c, liver function tests). The information gathered in this trial will be utilized in the development of a fully powered Type 2 Hybrid Effectiveness-Implementation Trial that will test the effectiveness of the identified implementation strategies and impact of the FI program on clinical outcomes. DISCUSSION: By integrating PRISM and RE-AIM within an iterative ROIO design, this study will generate a scalable, contextresponsive implementation model for addressing FI in pediatric healthcare settings. Findings will inform sustainable strategies that link families to highquality nutrition support programs and improve nutritionrelated health outcomes for lowincome children. TRIAL REGISTRATION: NCT06661538. CI - (c) 2026. The Author(s). FAU - Rhee, Kyung E AU - Rhee KE AD - Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. K1rhee@health.ucsd.edu. AD - Rady Children's Health, San Diego, CA, USA. K1rhee@health.ucsd.edu. AD - Department of Pediatrics, UC San Diego School of Medicine, 9500 Gilman Drive, MC 0874, La Jolla, CA, 92093, USA. K1rhee@health.ucsd.edu. FAU - Hiller-Venegas, Sarah AU - Hiller-Venegas S AD - Herbert Wertheim School of Public Health, University of California San Diego, La Jolla, CA, USA. FAU - Viglione, Clare AU - Viglione C AD - Herbert Wertheim School of Public Health, University of California San Diego, La Jolla, CA, USA. FAU - Polich, Michelle A AU - Polich MA AD - Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. AD - Rady Children's Health, San Diego, CA, USA. FAU - Huang, Jeannie S AU - Huang JS AD - Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. AD - Rady Children's Health, San Diego, CA, USA. FAU - Kim, Jane J AU - Kim JJ AD - Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. AD - Rady Children's Health, San Diego, CA, USA. FAU - Bajwa, Mandeep S AU - Bajwa MS AD - Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. AD - Rady Children's Health, San Diego, CA, USA. FAU - Zive, Michelle AU - Zive M AD - Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. FAU - Eichen, Dawn M AU - Eichen DM AD - Department of Pediatrics, University of California San Diego, La Jolla, CA, USA. FAU - Strong, David R AU - Strong DR AD - Herbert Wertheim School of Public Health, University of California San Diego, La Jolla, CA, USA. AD - Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. FAU - Stadnick, Nicole A AU - Stadnick NA AD - Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. AD - UC San Diego ACTRI Dissemination and Implementation Science Center, La Jolla, CA, USA. AD - Child and Adolescent Services Research Center, San Diego, CA, USA. FAU - Brookman-Frazee, Lauren AU - Brookman-Frazee L AD - Department of Psychiatry, University of California San Diego, La Jolla, CA, USA. AD - UC San Diego ACTRI Dissemination and Implementation Science Center, La Jolla, CA, USA. AD - Child and Adolescent Services Research Center, San Diego, CA, USA. LA - eng SI - ClinicalTrials.gov/NCT06661538 GR - R01 DK140573/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20260619 PL - England TA - Implement Sci Commun JT - Implementation science communications JID - 101764360 PMC - PMC13528015 OTO - NOTNLM OT - Food insecurity OT - Nutrition insecurity OT - PRISM OT - Pediatrics OT - RE-AIM OT - Roll-Out Implementation and Optimization (ROIO) trial COIS- Declarations. Ethics approval and consent to participate: This study obtained ethics approval from the University of California San Diego Institutional Review Board (protocol # 810869). Consent for publication: Not applicable Competing interests: The authors declare no competing interests. EDAT- 2026/06/20 00:39 MHDA- 2026/06/20 00:40 PMCR- 2026/06/19 CRDT- 2026/06/19 23:53 PHST- 2026/05/01 00:00 [received] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/06/20 00:40 [medline] PHST- 2026/06/20 00:39 [pubmed] PHST- 2026/06/19 23:53 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10.1186/s43058-026-01025-7 [pii] AID - 1025 [pii] AID - 10.1186/s43058-026-01025-7 [doi] PST - epublish SO - Implement Sci Commun. 2026 Jun 19;7(1):171. doi: 10.1186/s43058-026-01025-7. PMID- 42321687 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260904 IS - 1471-2415 (Electronic) IS - 1471-2415 (Linking) VI - 26 IP - 1 DP - 2026 Jun 19 TI - Agreement between Pentacam HR and Visionix VX650 system for corneal and anterior chamber parameters. LID - 10.1186/s12886-026-05054-7 [doi] LID - 534 AB - PURPOSE: To evaluate the agreement in anterior segment measurements obtained with Pentacam HR and Visionix VX650 topographers, in terms of keratometry, pachymetry and anterior chamber parameters in healthy eyes. METHODS: Inclusion criteria consisted of healthy eyes with no history of ocular pathology or surgery. Measurements of central corneal thickness (CCT), minimum corneal thickness (MCT), anterior and posterior keratometry (K1, K2), anterior chamber depth (ACD), and anterior chamber angle (ACA) were taken using the Pentacam HR and Visionix VX650. Differences between devices were assessed with paired Student's t-tests, and agreement was evaluated using Bland-Altman plots. RESULTS: Fifty-five eyes from 55 healthy participants mean age 32.55 +/- 12.60 years) were examined. Anterior keratometry and MCT showed clinically acceptable agreement between devices, with no significant differences (p > 0.164). Pentacam HR reported steeper posterior keratometry, smaller ACD, lower CCT and larger ACA values compared with VX650 (p < 0.001). For CCT and MCT, ranges of agreement were large, with values of +/- 27.07 and 55.41 mum, respectively. However, the ranges of agreement for anterior K1 and K2 were smaller, with values of +/- 0.11 and 0.11 mm, respectively. Likewise, the ranges of agreement for ACD and ACA were also clinically significant, with a clear trend of VX650 to provide longer ACD measurements and lower ACA estimates. CONCLUSIONS: Anterior corneal keratometry measured with the Pentacam HR and Visionix VX650 exhibit acceptable inter-device agreement. However, caution should be exercised regarding their interchangeability, especially when making decisions that require precise thickness (refractive surgery screening) or anterior chamber parameters (phakic intraocular lens implantation). CI - (c) 2026. The Author(s). FAU - Barberan-Bernardos, Laura AU - Barberan-Bernardos L AD - Department of Optics, Pharmacology and Anatomy, University of Alicante, Crta San Vicente del Raspeig s/n, San Vicente del Raspeig, Alicante, 03016, Spain. FAU - Ariza-Gracia, Miguel Angel AU - Ariza-Gracia MA AD - ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland. FAU - Pinero, David P AU - Pinero DP AD - Department of Optics, Pharmacology and Anatomy, University of Alicante, Crta San Vicente del Raspeig s/n, San Vicente del Raspeig, Alicante, 03016, Spain. david.pinyero@ua.es. AD - Department of Ophthalmology (IMQO-Oftalmar), Vithas Medimar International Hospital, Alicante, Spain. david.pinyero@ua.es. LA - eng GR - CIACIF/2022/073/Generalitat Valenciana/ PT - Comparative Study PT - Journal Article DEP - 20260619 PL - England TA - BMC Ophthalmol JT - BMC ophthalmology JID - 100967802 SB - IM MH - Humans MH - *Corneal Topography/instrumentation MH - *Anterior Chamber/anatomy & histology MH - Female MH - Adult MH - *Cornea/anatomy & histology MH - Male MH - Corneal Pachymetry/instrumentation MH - Middle Aged MH - Young Adult MH - Reproducibility of Results MH - Healthy Volunteers MH - Adolescent MH - Prospective Studies PMC - PMC13536767 OTO - NOTNLM OT - Anterior segment imaging OT - Corneal topography OT - Keratometry OT - Pachymetry OT - Pentacam HR OT - Visionix VX650 COIS- Declarations. Ethical approval: The study followed the tenets of the Declaration of Helsinki and was approved by the ethics committee of the University of Alicante (UA-2023-01-19_2). Consent to participate: All recruited patients were informed about the nature of the study and provided written informed consent prior to their inclusion. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/20 00:38 MHDA- 2026/09/02 05:36 PMCR- 2026/06/19 CRDT- 2026/06/19 23:45 PHST- 2026/02/27 00:00 [received] PHST- 2026/06/16 00:00 [accepted] PHST- 2026/09/02 05:36 [medline] PHST- 2026/06/20 00:38 [pubmed] PHST- 2026/06/19 23:45 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10.1186/s12886-026-05054-7 [pii] AID - 5054 [pii] AID - 10.1186/s12886-026-05054-7 [doi] PST - epublish SO - BMC Ophthalmol. 2026 Jun 19;26(1):534. doi: 10.1186/s12886-026-05054-7. PMID- 42321595 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261014 IS - 1098-108X (Electronic) IS - 0276-3478 (Print) IS - 0276-3478 (Linking) VI - 59 IP - 10 DP - 2026 Oct TI - Comparative Properties of Two Self-Report Measures of Avoidant/Restrictive Food Intake Disorder: Psychometric and Clinical Utility. PG - 2226-2236 LID - 10.1002/eat.70151 [doi] AB - OBJECTIVES: We compared two measures of Avoidant/Restrictive Food Intake Disorder (ARFID)-the NIAS and the PARDI-AR-Q to determine which demonstrates better psychometric and clinical utility. METHODS: The study was pre-registered (OSF; DOI 10.17605/OSF.IO/N8WBF). Participants (aged >/= 18 years, BMI > 18.5) were recruited via Prolific and screened via a short written description of their fussy eating behaviors. After review, eligible participants (N = 156) were invited to complete a second online survey, consisting of the NIAS, PARDI-AR-Q, GAD-7, PHQ-9, CIA, and EDE-Q7. Exploratory factor analyses were conducted separately for the NIAS and PARDI-AR-Q dimensions, and then on combined items. Pearson's correlations examined associations within and across both ARFID measures. Categorical agreement between measures was examined. Correlations and multiple regressions determined the extent to which ARFID subscales accounted for variance across the broader clinical outcomes. RESULTS: All subscales within and across the NIAS and PARDI-AR-Q were significantly and positively correlated. The weakest association was observed between the NIAS Picky Eating subscale and the PARDI-AR-Q Sensory Sensitivity subscale-a pattern supported by the combined exploratory factor analysis, which yielded a four-factor model. The NIAS and PARDI-AR-Q showed significant, moderate case agreement. The PARDI-AR-Q showed much stronger evidence of clinical validity. DISCUSSION: Overall, the PARDI-AR-Q demonstrated greater clinical validity than the NIAS. The weak association between Picky Eating and Sensory Sensitivity suggests these measures capture distinct behavioral and motivational components of ARFID. CI - (c) 2026 The Author(s). International Journal of Eating Disorders published by Wiley Periodicals LLC. FAU - Nicholls-Clow, Rebecca AU - Nicholls-Clow R AUID- ORCID: 0009-0007-9941-5415 AD - School of Psychology, University of Sheffield, Sheffield, UK. FAU - Prudenzi, Arianna AU - Prudenzi A AUID- ORCID: 0000-0002-5185-2807 AD - School of Psychology, University of Sheffield, Sheffield, UK. FAU - Waller, Glenn AU - Waller G AUID- ORCID: 0000-0001-7794-9546 AD - Department of Psychology, University of Warwick, Coventry, UK. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260619 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - Psychometrics MH - Female MH - Adult MH - Male MH - *Self Report MH - *Avoidant Restrictive Food Intake Disorder/diagnosis/psychology MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - Middle Aged MH - Reproducibility of Results MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Factor Analysis, Statistical PMC - PMC13655934 OTO - NOTNLM OT - Avoidant/Restrictive Food Intake Disorder (ARFID) OT - NIAS OT - PARDI-AR-Q OT - clinical utility OT - eating disorders OT - psychometrics OT - self-report measures COIS- The authors declare no conflicts of interest. EDAT- 2026/06/20 00:37 MHDA- 2026/10/12 11:41 PMCR- 2026/10/12 CRDT- 2026/06/19 23:26 PHST- 2026/04/29 00:00 [revised] PHST- 2026/02/26 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/10/12 11:41 [medline] PHST- 2026/06/20 00:37 [pubmed] PHST- 2026/06/19 23:26 [entrez] PHST- 2026/10/12 00:00 [pmc-release] AID - EAT70151 [pii] AID - 10.1002/eat.70151 [doi] PST - ppublish SO - Int J Eat Disord. 2026 Oct;59(10):2226-2236. doi: 10.1002/eat.70151. Epub 2026 Jun 19. PMID- 42321360 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20261007 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 19 TI - Medicine ball throw distance weighted with height-to-mass ratio aligns with other physical fitness tasks. LID - 10.1038/s41598-026-58353-w [doi] LID - 28114 AB - The traditional Medicine Ball Throw (MBT(T)) for assessing upper-extremity explosive strength inherently favours heavier and taller participants. We designed three alternative indices to adjust for this anthropometric bias: (1) multiplying MBT(T) by the height-to-mass ratio (MBT(A1)), (2) dividing MBT(T) by the product of mass and height (MBT(A2)), and (3) dividing MBT(T) by the body mass index (MBT(A3)). Using age- and sex-adjusted LMS-based z-scores from two independent cohorts (821 children, aged 8.3 +/- 0.7 years; 354 adolescents, aged 14.4 +/- 2.2 years), we compared the variants' alignment with the concave BMI-profiles of five standard fitness tests (6-minute run, standing long jump, jump sideways, 4 x 10 m shuttle run, push-ups). The three anthropometrically enriched variants yielded significantly better goodness of fit than MBT(T) with MBT(A1) performing best overall. Furthermore, when deployed as independent covariates, the enriched indices demonstrated systematically higher predictive power for standard fitness tasks than the unadjusted distance. We recommend adjusting MBT(T) via the height-to-mass ratio for a fairer assessment, though its structural overlap with BMI requires caution in predictive models. CI - (c) 2026. The Author(s). FAU - Jarnig, Gerald AU - Jarnig G AUID- ORCID: 0000-0003-0885-5866 AD - Department of Human Movement Science, Sport and Health, University of Graz, Mozartgasse 14, Graz, Austria. gerald.jarnig@uni-graz.at. FAU - Kliegl, Reinhold AU - Kliegl R AUID- ORCID: 0000-0002-0180-8488 AD - Department of Sports and Health Sciences, Division of Training and Movement Sciences, University of Potsdam, Potsdam, Germany. FAU - Kerbl, Reinhold AU - Kerbl R AUID- ORCID: 0009-0007-3567-2877 AD - Department of Pediatrics and Adolescent Medicine, LKH Hochsteiermark, Leoben, Austria. FAU - van Poppel, Mireille N M AU - van Poppel MNM AUID- ORCID: 0000-0001-5694-4324 AD - Department of Human Movement Science, Sport and Health, University of Graz, Mozartgasse 14, Graz, Austria. LA - eng GR - GZ:2025-0.021.608/Austrian Federal Ministry for Arts, Culture, Civil Service and Sport/ GR - GZ:2024-0.780.614/Austrian Federal Ministry of Education, Science and Research/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260619 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Physical Fitness/physiology MH - Body Mass Index MH - Adolescent MH - Female MH - Male MH - Child MH - *Body Height MH - Exercise Test/methods MH - Anthropometry PMC - PMC13554187 OTO - NOTNLM OT - Anthropometry OT - Athletic performance OT - Height-to-mass ratio OT - Medicine ball throw OT - Model validation OT - Physical fitness OT - Upper body strength COIS- Declarations. Competing interests: The authors declare no competing interests. Institutional review board: The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Research Ethics Committee of the University of Graz, Styria, Austria (GZ. 39/68/63 ex 2021/22). Informed consent: Informed consent was obtained from all the subjects involved in the study. EDAT- 2026/06/20 00:37 MHDA- 2026/09/09 07:07 PMCR- 2026/06/19 CRDT- 2026/06/19 23:20 PHST- 2026/02/07 00:00 [received] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/09/09 07:07 [medline] PHST- 2026/06/20 00:37 [pubmed] PHST- 2026/06/19 23:20 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10.1038/s41598-026-58353-w [pii] AID - 58353 [pii] AID - 10.1038/s41598-026-58353-w [doi] PST - epublish SO - Sci Rep. 2026 Jun 19;16(1):28114. doi: 10.1038/s41598-026-58353-w. PMID- 42321344 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20261005 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 19 TI - Associations of lifestyle and biological factors with body image among reproductive-aged women: a cross-sectional study. LID - 10.1038/s41598-026-56798-7 [doi] LID - 28125 AB - This study aimed to identify lifestyle and biological factors associated with body image among reproductive-aged women, focusing on physical activity, sedentary time, sleep, BMI, premenstrual symptoms (PMS), and sleep quality. A secondary aim was to explore interrelationships among these factors to contextualise their combined association with body image. In this cross-sectional online survey, 291 women aged 18-45 years participated (mean age: 27.16 +/- 0.36 years). Validated questionnaires were used to assess body image (Body Appreciation Scale), physical activity (Global Physical Activity Questionnaire), sleep quality (Sleep Quality Scale), BMI, and PMS (Premenstrual Assessment Form-Short Form). Data were analysed with IBM SPSS 28.0 using multivariable linear regression and correlation analyses (p < 0.05). Higher BMI, greater PMS severity, poorer sleep quality and longer sedentary time were significantly associated with lower body appreciation. Correlations were found between PMS and sleep quality (r = 0.309; p < 0.001), PMS and work-related moderate activity (r = 0.119; p = 0.043), and sleep quality and work-related moderate activity (r = 0.169; p = 0.004). No significant associations were observed for recreational physical activity with PMS (r=-0.041; p = 0.544) or sleep quality (r=-0.040; p = 0.498). Body image in reproductive-aged women was associated with both lifestyle behaviours and biological symptom burden. The findings suggest that supporting positive body image may benefit from integrated approaches addressing sedentary behaviour, sleep quality and menstrual health alongside weight-related factors. CI - (c) 2026. The Author(s). FAU - Dozsa-Juhasz, Olivia AU - Dozsa-Juhasz O AD - Institute of Physiotherapy and Sport Science, Faculty of Health Sciences, University of Pecs, Pecs, Hungary. FAU - Premusz, Viktoria AU - Premusz V AD - Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pecs, Pecs, Hungary. FAU - Acs, Pongrac AU - Acs P AD - Physical Activity Research Group, Szentagothai Research Centre, University of Pecs, Pecs, Hungary. FAU - Hock, Marta AU - Hock M AD - Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pecs, Pecs, Hungary. FAU - Makai, Alexandra AU - Makai A AD - Doctoral School of Health Sciences, Faculty of Health Sciences, University of Pecs, Pecs, Hungary. alexandra.makai@etk.pte.hu. LA - eng PT - Journal Article DEP - 20260619 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Adult MH - Cross-Sectional Studies MH - *Body Image/psychology MH - *Life Style MH - Middle Aged MH - Body Mass Index MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - Exercise MH - Sleep Quality MH - Sedentary Behavior MH - Premenstrual Syndrome/psychology MH - Sleep MH - Body Satisfaction PMC - PMC13554112 OTO - NOTNLM OT - 24-hour movement behaviours OT - Body image OT - Premenstrual syndrome OT - Sleep quality OT - Women's health COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: The study was registered by the U.S. National Institute of Health (clinicaltrial.gov, Identifier: NCT06146673; date of registration: 23/11/2023) and approved by the Medical Research Council of Hungary (Identifier: BM/23899-1/2023). A research protocol adhering to the principles of the Helsinki Declaration was followed. Participants provided voluntary, uninfluenced consent for the anonymous use and publication of their data following appropriate information provision. EDAT- 2026/06/20 00:38 MHDA- 2026/09/09 07:07 PMCR- 2026/06/19 CRDT- 2026/06/19 23:19 PHST- 2025/11/04 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/09/09 07:07 [medline] PHST- 2026/06/20 00:38 [pubmed] PHST- 2026/06/19 23:19 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10.1038/s41598-026-56798-7 [pii] AID - 56798 [pii] AID - 10.1038/s41598-026-56798-7 [doi] PST - epublish SO - Sci Rep. 2026 Jun 19;16(1):28125. doi: 10.1038/s41598-026-56798-7. PMID- 42320787 OWN - NLM STAT- MEDLINE DCOM- 20260812 LR - 20260923 IS - 1559-2030 (Electronic) IS - 1551-7144 (Print) IS - 1551-7144 (Linking) VI - 168 DP - 2026 Sep TI - Protocol for a randomized, controlled trial of a bioactive dietary polyphenol preparation to promote resilience in healthy individuals. PG - 108382 LID - S1551-7144(26)00168-0 [pii] LID - 10.1016/j.cct.2026.108382 [doi] AB - Botanicals and nutritional supplements have gained tremendous popularity as natural approaches to enhancing physical and mental health. However, alongside this trend, there is a growing recognition of the importance of rigorous human studies to validate the absorption, bioavailability, safety and physiological effects of these botanicals. Understanding the effects of these compounds on stress-related outcomes is crucial for ensuring their efficacy and safety to promote stress resilience and overall health. This report describes the design of a parallel arm, randomized, double-blind, placebo-controlled clinical trial to assess the absorption and bioavailability of a 5-week intervention of a daily Bioactive Dietary Polyphenol Preparation (BDPP) consisting of Concord grape juice (CGJ), grape seed polyphenol extract (GSPE), and trans-resveratrol (RSV). Healthy adults (ages 18-55 years) are randomized to receive low, medium, or high doses of BDPP or matching placebo. In addition to pharmacokinetic profiling, the study will evaluate the effects of BDPP on immune function and behavioral measures of stress. The trier social stress test (TSST) will probe acute response to stress. Findings from this trial are intended to lay the foundation for future, larger studies of BDPP and other natural polyphenol-rich products investigating the clinical utility of phenolic supplements for stress resilience and health. CI - Published by Elsevier Inc. FAU - Marchidan, M M AU - Marchidan MM AD - The Dennis S Charney, MD, Depression and Anxiety Discovery Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States. FAU - Rizk, M M AU - Rizk MM AD - The Dennis S Charney, MD, Depression and Anxiety Discovery Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States. FAU - Karpman, E AU - Karpman E AD - The Dennis S Charney, MD, Depression and Anxiety Discovery Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States. FAU - Lizzano, A AU - Lizzano A AD - The Dennis S Charney, MD, Depression and Anxiety Discovery Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States. FAU - Fremont, R AU - Fremont R AD - The Dennis S Charney, MD, Depression and Anxiety Discovery Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States. FAU - Dobbs, M F AU - Dobbs MF AD - The Dennis S Charney, MD, Depression and Anxiety Discovery Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States. FAU - Lee, J H AU - Lee JH AD - Centers for Biostatistics, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, United States. FAU - Irizar, H AU - Irizar H AD - Centers for Biostatistics, Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, NY, United States. FAU - Lyu, W AU - Lyu W AD - New Use Agriculture and Natural Plant Products Program, Department of Plant Biology and the Rutgers Core Facility for Natural Products and Bioanalysis, New Brunswick, NJ, United States; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, United States. FAU - Yin, Z AU - Yin Z AD - New Use Agriculture and Natural Plant Products Program, Department of Plant Biology and the Rutgers Core Facility for Natural Products and Bioanalysis, New Brunswick, NJ, United States. FAU - Wu, Q AU - Wu Q AD - New Use Agriculture and Natural Plant Products Program, Department of Plant Biology and the Rutgers Core Facility for Natural Products and Bioanalysis, New Brunswick, NJ, United States; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, United States. FAU - Simon, J E AU - Simon JE AD - New Use Agriculture and Natural Plant Products Program, Department of Plant Biology and the Rutgers Core Facility for Natural Products and Bioanalysis, New Brunswick, NJ, United States; Department of Medicinal Chemistry, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, United States. FAU - Ferruzzi, M AU - Ferruzzi M AD - Department of Food, Bioprocessing and Nutrition Sciences, Plants for Human Health Institute, North Carolina State University, Kannapolis, NC, United States. FAU - Pasinetti, G M AU - Pasinetti GM AD - Geriatrics Research, Education and Clinical Center (GRECC), James J. Peters VA Medical Center, Bronx, NY, United States; The Bronx Veterans Medical Research Foundation, Bronx, NY, USA; VA Sequencing Collaborations United for Research and Epidemiology (seqCURE), James J. Peters VA Medical Center, Bronx, NY, USA. Electronic address: giulio.pasinetti@va.gov. FAU - Murrough, J W AU - Murrough JW AD - The Dennis S Charney, MD, Depression and Anxiety Discovery Center, Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States; Nash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States; VISN 2 Mental Illness Research, Education, and Clinical Centers (MIRECC), James J. Peters VA Medical Center, Bronx, New York, United States. Electronic address: james.murrough@mssm.edu. LA - eng GR - R01 MH104559/MH/NIMH NIH HHS/United States GR - U19 AT010835/AT/NCCIH NIH HHS/United States GR - UL1 TR004419/TR/NCATS NIH HHS/United States PT - Clinical Trial Protocol PT - Journal Article DEP - 20260619 PL - United States TA - Contemp Clin Trials JT - Contemporary clinical trials JID - 101242342 RN - 0 (Grape Seed Extract) RN - 0 (Polyphenols) RN - Q369O8926L (Resveratrol) RN - 0 (Stilbenes) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Biological Availability MH - Dietary Supplements MH - Double-Blind Method MH - Fruit and Vegetable Juices MH - *Grape Seed Extract/pharmacokinetics/administration & dosage MH - *Polyphenols/pharmacokinetics/administration & dosage MH - Research Design MH - *Resilience, Psychological MH - Resveratrol MH - *Stilbenes/pharmacokinetics MH - *Stress, Psychological/drug therapy PMC - PMC13405406 MID - NIHMS2194333 OTO - NOTNLM OT - Clinical trial OT - Complementary and alternative medicine OT - Immune system OT - Inflammation OT - Methodology OT - Polyphenols OT - Stress COIS- Declaration of competing interest Mario G. Ferruzzi reports funding provided by NIH-NCCIH. MGF serves as a trustee/director on the boards of non-profit societies the Institute for the Advancement of Food and Nutrition Sciences and the International Food Information Council. MGF serves as a member of the board of directors for Sensient Technologies which manufactures food ingredients including flavors and colors If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. James E. Simon reports funds from the New Jersey Agricultural Experiment Station (NJAES) via a 5-year HATCH project #NJ12170; Accession #1025914 which supports a broad range of research with natural products and health and at times some lab supplies in support of this project were purchased. James W. Murrough is a full-time employee of the Icahn School of Medicine at Mount Sinai and a part-time employee of the U.S. Department of Veterans Affairs. In the past 36 months, Dr. Murrough has provided paid consultation services for Acadia Pharmaceuticals, Autobahn Therapeutics, Inc., Biohaven Pharmaceuticals, Inc., Clexio Biosciences, Definium Therapeutics, Frontier Pharma, LLC, HMP Collective, Janssen Pharmaceuticals, Merck & Co., Inc., Otsuka Pharmaceutical, Ltd, WCG Clinical, and Inc., Xenon Pharmaceuticals, Inc. Dr. Murrough is a named inventor on patent applications filed by the Icahn School of Medicine at Mount Sinai covering methods for the treatment of mood and anxiety disorders, including approaches involving KCNQ channel openers, psychedelic compounds, immunotherapeutic strategies, and digital/sensor-based interventions for emotion regulation. None of these applications has been issued as a patent or licensed, and Dr. Murrough has received no royalties or financial benefit from them. All other authors report no conflicts of interest. EDAT- 2026/06/20 00:39 MHDA- 2026/08/12 23:34 PMCR- 2026/07/28 CRDT- 2026/06/19 19:36 PHST- 2025/03/01 00:00 [received] PHST- 2026/06/09 00:00 [revised] PHST- 2026/06/18 00:00 [accepted] PHST- 2026/08/12 23:34 [medline] PHST- 2026/06/20 00:39 [pubmed] PHST- 2026/06/19 19:36 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - S1551-7144(26)00168-0 [pii] AID - 10.1016/j.cct.2026.108382 [doi] PST - ppublish SO - Contemp Clin Trials. 2026 Sep;168:108382. doi: 10.1016/j.cct.2026.108382. Epub 2026 Jun 19. PMID- 42318005 OWN - NLM STAT- MEDLINE DCOM- 20260619 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Machine learning-based prediction models for severe Mycoplasma pneumoniae pneumonia in Chinese children: a systematic review and meta-analysis of prediction model performance. PG - 1793116 LID - 10.3389/fpubh.2026.1793116 [doi] LID - 1793116 AB - OBJECTIVES: This study aimed to systematically evaluate the predictive performance and methodological characteristics of machine learning-based models for predicting progression to severe Mycoplasma pneumoniae pneumonia (SMPP) in pediatric patients. METHODS: A comprehensive literature search was conducted in PubMed, EMBASE, Web of Science, Cochrane Library, CNKI, and Wanfang databases from inception to November 2025 to identify studies developing or validating prediction models for SMPP in children. Data on study characteristics, modeling algorithms, predictors, and performance metrics were extracted. A narrative synthesis was performed to summarize model characteristics, predictors, and modeling approaches, while model discrimination was quantitatively synthesized using pooled area under the receiver operating characteristic curve (AUC). Subgroup analyses were conducted according to modeling algorithms. Methodological quality and risk of bias were assessed using the PROBAST tool. RESULTS: A total of 13 studies were included. The reported prevalence of hypoglycemia ranged from 17 to 33%. The AUC for predictive models ranged from 0.81 to 0.90. Subgroup analyses showed that machine learning-based models such as XGBoost and random forest generally reported higher AUC values compared with other modeling approaches. Commonly reported predictors included age, insulin use, body mass index, HbA1c, creatinine, and history of hypoglycemia. CONCLUSION: Research on risk prediction models for SMPP in children is still at a developmental stage. Although current models demonstrate high discriminatory performance, methodological limitations and limited clinical translation remain. Future studies should focus on developing robust, interpretable machine learning models and facilitating their integration into pediatric clinical practice. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/PROSPERO/ CRD42020190338. CI - Copyright (c) 2026 Cao, Nie, Wu and Liu. FAU - Cao, Juan AU - Cao J AD - College of Medicine and Health Sciences, China Three Gorges University, Yichang, Hubei, China. FAU - Nie, Jiao AU - Nie J AD - Department of Nursing, Jiangxi Provincial Children's Hospital, Nanchang, Jiangxi, China. FAU - Wu, Danxia AU - Wu D AD - Department of Respiratory Medicine, Jiangxi Provincial Children's Hospital, Nanchang, Jiangxi, China. FAU - Liu, Huiqin AU - Liu H AD - The First College of Clinical Medicine, China Three Gorges University, Yichang Central People's Hospital, Yichang, China. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260603 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Chinese people SB - IM MH - Child MH - Humans MH - Boosting Machine Learning Algorithms MH - China/epidemiology MH - *Machine Learning MH - Mycoplasma pneumoniae MH - *Pneumonia, Mycoplasma/diagnosis/epidemiology MH - Predictive Learning Models MH - East Asian People PMC - PMC13272165 OTO - NOTNLM OT - machine learning OT - meta-analysis OT - pediatrics OT - prediction model OT - severe Mycoplasma pneumoniae pneumonia COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/19 06:32 MHDA- 2026/06/19 06:33 PMCR- 2026/06/03 CRDT- 2026/06/19 04:53 PHST- 2026/01/21 00:00 [received] PHST- 2026/05/13 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/19 06:33 [medline] PHST- 2026/06/19 06:32 [pubmed] PHST- 2026/06/19 04:53 [entrez] PHST- 2026/06/03 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1793116 [doi] PST - epublish SO - Front Public Health. 2026 Jun 3;14:1793116. doi: 10.3389/fpubh.2026.1793116. eCollection 2026. PMID- 42317576 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260619 LR - 20260813 IS - 2753-6130 (Electronic) IS - 2753-6130 (Linking) VI - 15 DP - 2026 Jan-Dec TI - Increasing Physical, Emotional, and Social Wellbeing in Adolescents Following a Multi-Week Indian Classical Dance Program: Results From a Single-Arm Pilot Study. PG - 27536130261459352 LID - 10.1177/27536130261459352 [doi] LID - 27536130261459352 AB - BACKGROUND: The physical, emotional, and social wellbeing of U.S. high school-aged adolescents is a growing public health concern. OBJECTIVE: To describe the development and initial effects of an 8-week Bharatanatyam (Indian Classical Dance) intervention on wellbeing indicators in Midwestern high school students. METHODS: Using a single arm design, freshmen at a Midwestern high school completed an ethics-approved 8-week Bharatanatyam program teaching movements rooted in social cognitive theory and cultural foundations. At baseline, four, and 8 weeks, participants completed PROMIS Pediatric Profile-25 (Physical Function Mobility, Anxiety, Depressive Symptoms, Fatigue, Peer Relations, Pain Interference, and Pain Intensity), Body Appreciation Scale, Anti-Bias Behavior Scale (PSABBS), State Mindfulness Scale, and an 8-item acceptability questionnaire. Analyses included descriptive statistics, paired t-tests, Cohen's d effect sizes, Pearson's correlations, and linear regressions. RESULTS: Forty-six students provided assent and parental consent and completed the intervention. Most were female (62%) and Caucasian (80%). Feasibility and retention indicators were high (83-89%). Fifty-nine percent reported independent exercise 2-5 times weekly. Controlling for exercise frequency, significant decreases (P < 0.05) were observed between baseline and 8 weeks in PROMIS Anxiety (d = .80), Depressive Symptoms (d = .51), Fatigue (d = .61), and Pain Intensity (d = .77), with significant increases in Peer Relations (d = .80) and Body Appreciation (d = .97). Positive associations were found between anti-bias attitudes and lower anxiety (r = .485, P < .05), depressive symptoms (r = .510, P < .01), fatigue (r = .395, P < .05), and pain intensity (r = .567, P < .05). Anti-bias attitudes had significant associations with pain intensity, depression, and anxiety, and mindfulness was significantly associated with (P < .05) body appreciation. CONCLUSION: This study provides initial evidence that an 8-week Bharatanatyam program improved emotional health and physical symptoms (ie, fatigue and pain) among adolescents, with mindfulness and anti-bias attitudes associated with overall wellbeing. Further testing with more rigorous study designs is warranted. CI - (c) The Author(s) 2026. FAU - Parthasarathy, Shruti AU - Parthasarathy S AUID- ORCID: 0009-0000-3523-3128 AD - Yale School of Public Health, Yale University, New Haven, CT, USA. AD - Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. RINGGOLD: 12244 FAU - Sauer, Christina AU - Sauer C AD - Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. RINGGOLD: 12244 FAU - Horowitz, Bruriah AU - Horowitz B AD - Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. RINGGOLD: 12244 FAU - Victorson, David AU - Victorson D AUID- ORCID: 0000-0002-3530-8633 AD - Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. RINGGOLD: 12244 LA - eng PT - Journal Article DEP - 20260616 PL - United States TA - Glob Adv Integr Med Health JT - Global advances in integrative medicine and health JID - 9918556687906676 PMC - PMC13272864 OTO - NOTNLM OT - adolescent OT - bharatanatyam OT - wellbeing COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/06/19 06:32 MHDA- 2026/06/19 06:33 PMCR- 2026/06/16 CRDT- 2026/06/19 04:49 PHST- 2025/11/23 00:00 [received] PHST- 2026/05/20 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/06/19 06:33 [medline] PHST- 2026/06/19 06:32 [pubmed] PHST- 2026/06/19 04:49 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 10.1177_27536130261459352 [pii] AID - 10.1177/27536130261459352 [doi] PST - epublish SO - Glob Adv Integr Med Health. 2026 Jun 16;15:27536130261459352. doi: 10.1177/27536130261459352. eCollection 2026 Jan-Dec. PMID- 42316462 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260619 LR - 20260813 IS - 1738-3684 (Print) IS - 1976-3026 (Electronic) IS - 1738-3684 (Linking) VI - 23 IP - 6 DP - 2026 Jun TI - Paraben and Phthalate Exposure in Adolescents With Attention-Deficit/Hyperactivity Disorder: A Case-Control Study. PG - 773-789 LID - 10.30773/pi.2025.0444 [doi] AB - OBJECTIVE: This case-control study compared urinary concentrations of parabens and phthalate metabolites between adolescents with attention-deficit/hyperactivity disorder (ADHD) and healthy peers and examined whether product-use behaviors accounted for observed exposure differences. METHODS: Adolescents aged 12-17 years with clinically diagnosed ADHD (n=39) and age- and sex-matched healthy controls (n=41) were recruited. Urinary concentrations of seven parabens and ten phthalate metabolites were quantified using validated high-performance liquid chromatography and gas chromatography-mass spectrometry protocols. ADHD symptoms were assessed using Conners Parent and Adolescent Rating Scales. Group comparisons were conducted using t-tests with effect sizes (Cohen's d). Multivariable logistic regression, factorial analysis of covariance (ANCOVA) models (reporting partial eta(2)), and multiple mediation analyses were performed, adjusting for household income, parental education, and body mass index. RESULTS: Differences in the urinary concentrations of several parabens and phthalate metabolites were observed between adolescents with ADHD and controls. However, detection frequencies varied across analytes, and findings for compounds with low detection frequency should be interpreted with caution. In multivariable logistic regression, an association between dimethyl phthalate and ADHD status was observed (odds ratio=6.13; 95% confidence interval, 1.10-34.34), with improved model discrimination (Deltachi(2)=17.2, p=0.002; area under the receiver operating characteristic curve, 0.856-->0.921); however, this finding should be interpreted with caution given its low detection frequency. In ANCOVA models adjusting for product-use behaviors, group differences remained significant only for dimethyl phthalate (F(1, 71)=7.97, p=0.006, eta(2)=0.099); however, this finding should likewise be interpreted with caution due to its low detection frequency. Mediation analyses indicated that recent personal care product use did not substantially mediate the association between ADHD status and chemical exposure levels. CONCLUSION: Adolescents with ADHD showed differences in internal exposure to selected parabens and phthalate metabolites. These findings should be interpreted with caution, particularly for analytes with low detection frequency. Overall, these findings suggest that exposure differences may reflect behavior-linked vulnerability patterns during adolescence rather than short-term cosmetic use alone. Longitudinal studies are needed to clarify temporal and causal pathways. FAU - Terzioglu, Merve Aktas AU - Terzioglu MA AD - Pamukkale University, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Denizli, Turkiye. merveaktasterzioglu@gmail.com. FAU - Patlar, Seyfiye AU - Patlar S AD - Pamukkale University, Faculty of Medicine, Department of Child and Adolescent Psychiatry, Denizli, Turkiye. FAU - Onac, Canan AU - Onac C AD - Pamukkale University, Faculty of Science, Department of Chemistry and Advanced Technology Application and Research Center, Denizli, Turkiye. FAU - Cort, Aysegul AU - Cort A AD - Pamukkale University, Faculty of Medicine, Department of Biochemistry, Denizli, Turkiye. FAU - Ata, Melek Tunc AU - Ata MT AD - Pamukkale University, Faculty of Medicine, Department of Physiology, Denizli, Turkiye. LA - eng GR - 2023IAP003/Pamukkale University/ PT - Journal Article DEP - 20260608 PL - Korea (South) TA - Psychiatry Investig JT - Psychiatry investigation JID - 101242994 PMC - PMC13284555 OTO - NOTNLM OT - ADHD OT - Adolescent mental health OT - Paraben exposure OT - Personal care products OT - Phthalate exposure COIS- Conflicts of Interest The authors have no potential conflicts of interest to disclose. EDAT- 2026/06/19 06:33 MHDA- 2026/06/19 06:34 PMCR- 2026/06/01 CRDT- 2026/06/19 00:39 PHST- 2025/12/04 00:00 [received] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/06/19 06:34 [medline] PHST- 2026/06/19 06:33 [pubmed] PHST- 2026/06/19 00:39 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - pi.2025.0444 [pii] AID - pi-2025-0444 [pii] AID - 10.30773/pi.2025.0444 [doi] PST - ppublish SO - Psychiatry Investig. 2026 Jun;23(6):773-789. doi: 10.30773/pi.2025.0444. Epub 2026 Jun 8. PMID- 42316387 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260906 IS - 1472-6823 (Electronic) IS - 1472-6823 (Linking) VI - 26 IP - 1 DP - 2026 Jun 18 TI - Metabolic risk profiling in childhood obesity through hormonal dysfunction and genetic variants: findings from a retrospective study. LID - 10.1186/s12902-026-02336-5 [doi] LID - 253 AB - BACKGROUND: Childhood obesity is frequently accompanied by endocrine dysfunction and genetic susceptibility, but their combined contribution to metabolic risk remains insufficiently defined. This retrospective study evaluated hormonal, metabolic, and genetic determinants of metabolic syndrome (MetS) in children and adolescents with obesity. METHODS: Electronic medical records from January 2021 to May 2025 were reviewed. A total of 429 children and adolescents with obesity were included. Clinical, biochemical, endocrine, and targeted SNP genotyping data for FTO rs9939609, MC4R rs17782313, and LEPR rs1137101 were analyzed. MetS was defined according to pediatric criteria. Multivariable logistic regression and receiver operating characteristic analysis were performed. RESULTS: MetS was present in 187 participants (43.6%). Fasting glucose averaged 5.3 +/- 0.5 mmol/L, HbA1c averaged 5.24 +/- 0.22%, and median HOMA-IR was 4.4 (2.7-5.7). Insulin resistance was observed in 68.0% of Tanner stage I participants and 73.3% of Tanner stage II-V participants. Elevated HOMA-IR was strongly associated with MetS (OR = 2.89, 95% CI: 1.71-4.99, P < 0.001). Leptin was positively associated with MetS risk (OR = 1.32, 95% CI: 1.02-1.70, P = 0.033), whereas adiponectin was inversely associated (OR = 0.63, 95% CI: 0.49-0.80, P < 0.001). FTO and MC4R risk allele carriage independently predicted MetS, with ORs of 1.88 and 1.71, respectively. The combined endocrine-genetic model showed acceptable discrimination (AUC = 0.751). CONCLUSION: Insulin resistance, adipokine imbalance, and FTO/MC4R variants were independently associated with MetS in pediatric obesity. Integrated endocrine-genetic profiling may improve early metabolic risk stratification. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2026. The Author(s). FAU - Shi, Xueqin AU - Shi X AD - Department of Adolescent Health, Yancheng Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yancheng, Jiangsu, 224002, China. FAU - Wang, Qianqian AU - Wang Q AD - Department of Adolescent Health, Yancheng Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yancheng, Jiangsu, 224002, China. FAU - Yin, Wenli AU - Yin W AD - Department of Adolescent Health, Yancheng Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yancheng, Jiangsu, 224002, China. FAU - Zhou, Chong AU - Zhou C AD - Department of Adolescent Health, Yancheng Maternal and Child Health Care Hospital Affiliated to Yangzhou University, Yancheng, Jiangsu, 224002, China. zyx15189379320@163.com. LA - eng PT - Journal Article DEP - 20260618 PL - England TA - BMC Endocr Disord JT - BMC endocrine disorders JID - 101088676 RN - EC 1.14.11.33 (FTO protein, human) RN - EC 1.14.11.33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO) RN - 0 (Receptor, Melanocortin, Type 4) RN - 0 (MC4R protein, human) RN - 0 (Receptors, Leptin) RN - 0 (LEPR protein, human) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Retrospective Studies MH - *Metabolic Syndrome/genetics/epidemiology/etiology/metabolism MH - Child MH - Male MH - *Pediatric Obesity/genetics/complications/metabolism MH - *Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics MH - Adolescent MH - *Polymorphism, Single Nucleotide MH - Insulin Resistance MH - Receptor, Melanocortin, Type 4/genetics MH - Receptors, Leptin/genetics MH - Genetic Predisposition to Disease MH - Follow-Up Studies MH - Risk Factors MH - Prognosis MH - *Biomarkers/analysis PMC - PMC13543467 OTO - NOTNLM OT - Adipokines OT - Childhood obesity OT - FTO OT - Insulin resistance OT - MC4R OT - Metabolic syndrome COIS- Declarations. Ethical approval: This study has been approved by the Ethics Committee of Yancheng Maternal and Child Health Care Hospital Affiliated to Yangzhou University (Approval Number: 2025-LW-016). The Ethics Committee reviewed and approved the retrospective use of anonymized clinical and biochemical data, as well as the targeted genotyping of predefined obesity-related SNPs for the archived remaining blood samples. No additional sample collection was conducted. Since the risk of this study was extremely low, de-identified retrospective data and remaining biological samples were used, and it would not affect the diagnosis, treatment or clinical management of patients. Therefore, the Ethics Committee waived the requirement for individual informed consent. Consent to participate: Ethical approval was obtained from the Institutional Review Board of the hospital, and, as the study was retrospective and all data were anonymized, the requirement for informed consent was waived. Competing interests: The authors declare no competing interests. EDAT- 2026/06/19 06:33 MHDA- 2026/09/04 05:36 PMCR- 2026/06/18 CRDT- 2026/06/19 00:20 PHST- 2026/01/21 00:00 [received] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/09/04 05:36 [medline] PHST- 2026/06/19 06:33 [pubmed] PHST- 2026/06/19 00:20 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1186/s12902-026-02336-5 [pii] AID - 2336 [pii] AID - 10.1186/s12902-026-02336-5 [doi] PST - epublish SO - BMC Endocr Disord. 2026 Jun 18;26(1):253. doi: 10.1186/s12902-026-02336-5. PMID- 42316363 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260619 LR - 20260813 IS - 3059-4057 (Electronic) IS - 3059-4057 (Linking) VI - 12 IP - 1 DP - 2026 Jun 19 TI - Pulmonary adverse events associated with GLP-1 receptor agonists: a systematic review of respiratory safety signals. LID - 10.1186/s40842-026-00311-6 [doi] LID - 43 AB - BACKGROUND: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are among the most rapidly growing drug classes in contemporary medicine, approved for type 2 diabetes mellitus (T2DM) and obesity management. Although gastrointestinal adverse effects are well characterised, the pulmonary safety profile of GLP-1 RAs remains incompletely defined, representing an important evidence gap given the scale of global prescribing. OBJECTIVE: This systematic review aims to synthesise published evidence on respiratory adverse events temporally associated with GLP-1 RA therapy in adults, characterise their patterns and severity, appraise the risk of bias using validated design-appropriate tools, describe proposed pathophysiological mechanisms, and grade the certainty of evidence using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) framework. Given the heterogeneity of the included evidence-spanning case reports, pharmacovigilance analyses, and observational cohorts-this review is framed primarily as a signal-detection and evidence-mapping exercise rather than a causal-inference analysis. ELIGIBILITY CRITERIA: Adults (>/= 18 years) receiving any approved GLP-1 RA for any indication. Eligible study designs included randomised controlled trials (RCTs), retrospective and prospective observational cohorts, pharmacovigilance disproportionality analyses, and case reports or series. Studies were excluded if they enrolled paediatric populations, involved animal or in vitro experiments, reported only metabolic or cardiovascular outcomes without respiratory adverse-event data, or were narrative reviews, editorials, or commentaries without primary data. METHODS: A systematic review was conducted following PRISMA 2020 guidelines (PROSPERO: CRD420261305875). PubMed, Embase, and Scopus were searched from inception to January 2026. Risk of bias was assessed using the Cochrane Risk of Bias 2 (RoB2) tool for RCTs, the Newcastle-Ottawa Scale (NOS) for cohort studies, and Joanna Briggs Institute (JBI) checklists for case reports, case series, and pharmacovigilance studies. GRADE was applied at the outcome-domain level; evidence from uncontrolled designs (case reports, case series, pharmacovigilance analyses) was initially rated very low certainty, as these designs are inherently uncontrolled and start below the lowest GRADE tier. Given substantial heterogeneity, meta-analytic pooling was not performed; a pre-specified narrative synthesis following the Synthesis Without Meta-Analysis (SWiM) reporting guideline was conducted. RESULTS: Nineteen studies met inclusion criteria: four RCTs (n = 1,884 participants), five retrospective cohort studies (n = 1,122,653 participants), three pharmacovigilance analyses (n = 498,892 spontaneous adverse-event reports), and seven case reports or case series (n = 13 patients). Spontaneous reports do not represent unique exposed individuals and were not pooled with participant counts. Risk of bias: all four RCTs were rated low risk by RoB2 (with some concerns for open-label outcome ascertainment in three trials, a domain-specific issue that does not alter the overall RoB2 category from low); three of five cohort studies were rated moderate and one high risk by NOS (one cohort study rating not reported, classified as not reported/unable to rate); all three pharmacovigilance studies were rated high risk by JBI; and case reports were rated as methodologically adequate by JBI, though these instruments cannot overcome the inherent anecdotal nature and very limited generalisability of single-case designs. Upper respiratory tract infections (URTIs) were the most frequently reported adverse event (8 of 12 reporting studies, 66.7%), occurring at rates comparable to controls across RCTs (GRADE: MODERATE certainty). Pharmacovigilance analyses identified disproportionate reporting signals for dyspnoea and asthma-like events, particularly with exenatide, using the reporting odds ratio (ROR 2.14, 95% CI 1.88-2.43; Cazzola 2024); these signals are hypothesis-generating only and do not establish causality or incidence. Serious adverse events reported in temporal association with GLP-1 RA exposure included anaphylaxis with bronchospasm (n = 4 cases), acute eosinophilic pneumonia (n = 1), perioperative aspiration pneumonitis or pneumonia (multiple perioperative cases across two cohort studies and one case series), acute respiratory distress syndrome (ARDS; n = 2, one fatal requiring extracorporeal membrane oxygenation [ECMO]), and spontaneous pneumomediastinum (n = 1). A large global retrospective cohort study (n = 331,863 matched patients; Henney 2024) demonstrated a potentially meaningful reduction in incident pneumonia with GLP-1 RAs compared with dipeptidyl peptidase-4 (DPP-4) inhibitors (hazard ratio [HR] 0.60, 95% confidence interval [CI] 0.58-0.62; GRADE: LOW certainty); this finding should be interpreted cautiously given the retrospective design, active and non-inert comparator, and likelihood of residual confounding. Evidence certainty for serious respiratory events was very low, driven by sparse case reports and high-risk pharmacovigilance data. CONCLUSION: GLP-1 RA therapy has a respiratory safety profile that is neither uniformly benign nor hazardous, stratified by mechanism, agent subclass, and clinical context. Common upper airway symptoms are mild and comparable to controls. Rare but clinically consequential events-including anaphylaxis, eosinophilic pneumonia, perioperative aspiration, and ARDS-have been reported in temporal association with GLP-1 RA exposure, predominantly in case reports and pharmacovigilance data of very low certainty; these signals are hypothesis-generating and should not be interpreted as confirmed causal risks. Exendin-4-based agents (exenatide and lixisenatide) appear to carry the highest reported risk of hypersensitivity reactions, attributable to their non-human structural origin. Clinicians should maintain heightened awareness for aspiration risk in perioperative settings; individualised, extended pre-procedural fasting intervals calibrated to the specific agent's pharmacokinetic profile should be considered. Prospective, standardised, and adequately powered studies with pre-specified respiratory endpoints are required to move from signal detection to causal inference. CI - (c) 2026. The Author(s). FAU - Ahuja, Aarushi AU - Ahuja A AD - Department of Internal Medicine, Maulana Azad Medical College, New Delhi, Delhi, India. FAU - Prasad, Sai AU - Prasad S AD - Department of Internal Medicine, S. Nijalingappa Medical College, Navanagar, Bagalkote, Karnataka, 587102, India. saiprasad.jadi@gmail.com. FAU - Manoharan, Sahana AU - Manoharan S AD - Department of Internal Medicine, Tirunelveli Medical College, Tirunelveli, Tamil Nadu, India. FAU - Sen, Arya AU - Sen A AD - Department of Internal Medicine, Medical College and Hospital Kolkata, Kolkata, West Bengal, India. FAU - Rana, Richa AU - Rana R AD - Department of Internal Medicine, GMERS Medical College Sola, Ahmedabad, Gujarat, India. FAU - Mody, Mansi AU - Mody M AD - Department of Internal Medicine, MP Shah Government Medical College, Jamnagar, Gujarat, India. FAU - Paras, Fnu AU - Paras F AD - Department of Internal Medicine, Government Medical College Patiala, Patiala, Punjab, India. FAU - Archita, Archita AU - Archita A AD - Department of Internal Medicine, Ziauddin University, Karachi, Pakistan. FAU - Shaik, Sana AU - Shaik S AD - Department of Internal Medicine, Tbilisi State Medical University, Tbilisi, Georgia. FAU - Mehta, Kartik AU - Mehta K AD - Department of Internal Medicine, Maulana Azad Medical College, New Delhi, Delhi, India. FAU - Manoj, Rachel AU - Manoj R AD - Department of Internal Medicine, Nicolae Testemitanu State University of Medicine and Pharmacy, Chisinau, Republic of Moldova. FAU - Mishra, Prakashini AU - Mishra P AD - Department of Internal Medicine, Government Medical College, Chandigarh, India. FAU - Mehta, Subhi AU - Mehta S AD - Department of Internal Medicine, LLRM Medical College, Meerut, Uttar Pradesh, India. FAU - Kapoor, Pulkit AU - Kapoor P AD - Department of Internal Medicine, Punjab Institute of Medical Sciences, Jalandhar, Punjab, India. LA - eng PT - Journal Article PT - Review DEP - 20260619 PL - England TA - Cardiovasc Diabetol Endocrinol Rep JT - Cardiovascular diabetology. Endocrinology reports JID - 9918994893106676 PMC - PMC13281493 OTO - NOTNLM OT - Aspiration pneumonia OT - Exenatide OT - GLP-1 receptor agonists OT - GRADE OT - Liraglutide OT - Pharmacovigilance OT - Pulmonary adverse events OT - Respiratory safety OT - Semaglutide OT - Systematic review COIS- Declarations. Ethics approval and consent to participate: Not applicable. This study is a systematic review of previously published data and does not involve human participants or patient-level identifiable data. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/19 06:33 MHDA- 2026/06/19 06:34 PMCR- 2026/06/19 CRDT- 2026/06/19 00:19 PHST- 2026/03/27 00:00 [received] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/06/19 06:34 [medline] PHST- 2026/06/19 06:33 [pubmed] PHST- 2026/06/19 00:19 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - 10.1186/s40842-026-00311-6 [pii] AID - 311 [pii] AID - 10.1186/s40842-026-00311-6 [doi] PST - epublish SO - Cardiovasc Diabetol Endocrinol Rep. 2026 Jun 19;12(1):43. doi: 10.1186/s40842-026-00311-6. PMID- 42316345 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260905 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 26 IP - 1 DP - 2026 Jun 18 TI - Suicidal ideation and suicide attempts among adolescents and youth in the aftermath of the Tigray war, 2024: prevalence and associated factors. LID - 10.1186/s12888-026-08284-7 [doi] LID - 687 AB - BACKGROUND: Suicide is a leading cause of death among adolescents and youth globally and represents an important public health concern in low- and middle-income and conflict-affected settings. Prior evidence from Ethiopia showed substantial levels of suicidal behavior among young populations even before the recent conflict. Exposure to war-related trauma, violence, displacement, and disruption of health and social systems may further increase the risk of suicidality among adolescents and youth. However, there is limited evidence regarding suicidal ideation and suicide attempts among adolescents and youth in post-war Tigray, Ethiopia. Therefore, this study aimed to assess the prevalence and associated factors of suicidal ideation and suicide attempts among adolescents and youth in the aftermath of the Tigray War. METHODS: A school-based cross-sectional study was conducted among 599 adolescents and youth aged 15-24 years in post-war Tigray, Ethiopia, of whom 57.4% were female. Data were collected using validated tools assessing suicidal ideation, suicide attempts, depression, anxiety, post-traumatic stress disorder, and exposure to violence. Bivariate and multivariable logistic regression analyses were performed to identify factors associated with suicidal ideation and suicide attempts. RESULTS: The prevalence of suicidal ideation was 19.9% (95% CI: 16.7%, 23.3%), while the prevalence of suicide attempts was 9.7% (95% CI: 7.4%, 12.3%).Depression, anxiety, and post-traumatic stress disorder were significantly associated with both suicidal ideation and attempts. Sexual abuse and witnessing physical violence increased the odds of suicidal Attempts. However, physical activity was protective against suicidal ideation. CONCLUSION: The findings suggest that suicidal ideation and suicidal attempts represent important mental health concerns among adolescents and youth in post-war Tigray. Depression, anxiety, PTSD symptoms, and trauma-related experiences were significantly associated with suicidality in this study. Given the cross-sectional nature of the study, causal relationships cannot be inferred. Nevertheless, the findings underscore the need for strengthened adolescent mental health services and trauma-informed support programs in conflict-affected settings. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2026. The Author(s). FAU - Gebrehiwot, Tesfay Gebreslassie AU - Gebrehiwot TG AD - Department of Nursing, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. gslassie2023@gmail.com. FAU - Woldemariam, Guesh Teklu AU - Woldemariam GT AD - Department of Nursing, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. FAU - Tadese, Haileslassie Tesfay AU - Tadese HT AD - Department of Nursing, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. FAU - Gebremedhin, Haftom Tesfay AU - Gebremedhin HT AD - Department of Psychiatry, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. FAU - Beraki, Mulu Ftwi AU - Beraki MF AD - Department of Midwifery, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. FAU - Berhe, Abadi Kidanemariam AU - Berhe AK AD - Department of Public Health, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. AD - Tigray Health Research Institute, Mekelle, Tigray, Ethiopia. FAU - Gebremariam, Alem AU - Gebremariam A AD - Department of Public Health, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. AD - Tigray Health Research Institute, Mekelle, Tigray, Ethiopia. FAU - Gebre, Yemane Gebremariam AU - Gebre YG AD - Department of Pediatrics, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. FAU - Alemseged, Embay Amare AU - Alemseged EA AD - Department of Public Health, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. FAU - Tesfau, Yemane Berhane AU - Tesfau YB AD - Department of Public Health, College of Medicine and Health Sciences, Adigrat University, Adigrat, Ethiopia. LA - eng PT - Journal Article DEP - 20260618 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 SB - IM MH - Humans MH - *Suicidal Ideation MH - Ethiopia/epidemiology MH - Female MH - Adolescent MH - *Suicide, Attempted/statistics & numerical data/psychology MH - Prevalence MH - Male MH - Cross-Sectional Studies MH - Young Adult MH - Stress Disorders, Post-Traumatic/epidemiology/psychology MH - Exposure to Violence/statistics & numerical data/psychology MH - Risk Factors MH - Depression/epidemiology MH - Anxiety/epidemiology PMC - PMC13539823 OTO - NOTNLM OT - Ethiopia OT - Post-war OT - Suicidal ideation OT - Suicide attempt OT - Tigray OT - Youth COIS- Declarations. Ethical approval and consent to participate: The study was conducted after Ethical approval was secured from the Adigrat University College of Medicine and Health Sciences Health Research Ethics Review Committee (Reference Number: ADU.CMHS/HRERC/0009/2024) and permission letters were secured from the relevant education offices. Written informed consent was obtained from participants, and assent was obtained from those under 18 years of age in accordance with ethical guidelines. All participants were assured that their involvement was voluntary, would not impact their academic standing, and that the confidentiality of their data would be strictly maintained. A trained and qualified facilitator was available on-site for students to consult with any study-related questions. During the data collection process, privacy was ensured through appropriate seating arrangements and supervision procedures to maintain confidentiality and minimize peer influence during questionnaire completion. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/19 06:32 MHDA- 2026/09/03 05:37 PMCR- 2026/06/18 CRDT- 2026/06/19 00:18 PHST- 2025/12/17 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/09/03 05:37 [medline] PHST- 2026/06/19 06:32 [pubmed] PHST- 2026/06/19 00:18 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1186/s12888-026-08284-7 [pii] AID - 8284 [pii] AID - 10.1186/s12888-026-08284-7 [doi] PST - epublish SO - BMC Psychiatry. 2026 Jun 18;26(1):687. doi: 10.1186/s12888-026-08284-7. PMID- 42316329 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260827 LR - 20260829 IS - 2055-5784 (Print) IS - 2055-5784 (Electronic) IS - 2055-5784 (Linking) VI - 12 IP - 1 DP - 2026 Jun 18 TI - The feasibility of a novel exercise therapy and activity modification intervention for patients with Sever's disease. LID - 10.1186/s40814-026-01850-6 [doi] LID - 125 AB - BACKGROUND: Sever's disease (calcaneal apophysitis) is a common cause of heel pain in physically active youth. Evidence-based treatment options are limited, with no consensus for the standard of care. This study aimed to assess the feasibility of delivering an intervention comprising exercise therapy and pain-guided activity modification for youth patients with Sever's disease and to describe patient symptoms, functional limitations, psychosocial factors, and ultrasound imaging findings to inform future clinical trials. METHODS: This single-cohort study enrolled patients between 7 and 17 years old with Sever's disease. Participants received a comprehensive 12-week intervention combining daily Achilles-tendon loading exercises, activity modification using a pain-monitoring model, and patient education. Training diaries were provided to monitor adherence, daily activities, and pain. Feasibility was assessed via recruitment and retention rates, daily activity modification adherence, rehabilitation adherence, and safety. Secondary outcomes (patient-reported outcome measures, functional test battery, and ultrasound imaging) were collected at baseline and at 4-, 8-, and 12 weeks and were reported descriptively to characterize the biopsychosocial burden of the condition and inform selection of outcomes and hypotheses for future clinical trials. RESULTS: Of the 13 participants enrolled (7F/6 M, (mean +/- SD) age 11.5 +/- 2.5 years, BMI 21.6 +/- 4.6 kg/m(2)), recruitment and retention rate was 65% and 69%, respectively. Activity modification adherence was 91 +/- 28% (range 37-100%), and rehabilitation adherence was 91 +/- 25% (range 25-100%). Three adverse events occurred and each was unrelated to participation. All participants expressed satisfaction with the intervention (75% [10/10] very satisfied). CONCLUSIONS: Our findings support that this exercise therapy and activity modification intervention is feasible, safe, and appropriate for the treatment of Sever's disease. Intervention satisfaction ratings and favorable global rating of change scores reported imply that educating patients to use a pain-monitoring model, allowing for modified physical activity, is not detrimental to patients with Sever's disease. A larger randomized controlled trial is warranted to evaluate the effectiveness of this intervention. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT04816188. Registered 18th of March, 2021 retrospectively. CI - (c) 2026. The Author(s). FAU - Hanlon, Shawn L AU - Hanlon SL AUID- ORCID: 0000-0002-5866-9853 AD - Department of Kinesiology, California State University, Fullerton, CA, USA. shanlon@fullerton.edu. AD - Department of Physical Therapy, University of Delaware, Newark, DE, USA. shanlon@fullerton.edu. FAU - Seymore, Kayla D AU - Seymore KD AD - Department of Physical Therapy, University of Delaware, Newark, DE, USA. FAU - Potter, Morgan N AU - Potter MN AD - Department of Physical Therapy, University of Delaware, Newark, DE, USA. FAU - Bley, Bradley C AU - Bley BC AD - Delaware Sports Medicine, Wilmington, DE, USA. FAU - Silbernagel, Karin Gravare AU - Silbernagel KG AD - Department of Physical Therapy, University of Delaware, Newark, DE, USA. LA - eng SI - ClinicalTrials.gov/NCT04816188 GR - 001_2021/Eastern Athletic Trainer's Association/ GR - R01AR07203401/AR/NIAMS NIH HHS/United States GR - T32HD007490/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ GR - 1920DGP08/National Athletic Trainer's Association Research and Education Foundation/ GR - R01 AR072034/AR/NIAMS NIH HHS/United States GR - T32 HD007490/HD/NICHD NIH HHS/United States GR - R01AR07203401/AR/NIAMS NIH HHS/United States PT - Journal Article DEP - 20260618 PL - England TA - Pilot Feasibility Stud JT - Pilot and feasibility studies JID - 101676536 PMC - PMC13520403 OTO - NOTNLM OT - Apophysitis OT - Overuse injury OT - Pediatric OT - Treatment OT - Ultrasound COIS- Declarations. Ethics approval and consent to participate: This study was approved by the University of Delaware Institutional Review Board (ID: 1652996-3) and is registered with ClinicalTrials.gov (ID: NCT04816188). Written parental permission and child assent were required for all participants before enrollment. Consent for publication: Not applicable. Competing interests: All authors declare that they have no competing interests. EDAT- 2026/06/19 06:33 MHDA- 2026/06/19 06:34 PMCR- 2026/06/18 CRDT- 2026/06/19 00:17 PHST- 2024/11/15 00:00 [received] PHST- 2026/05/14 00:00 [accepted] PHST- 2026/06/19 06:34 [medline] PHST- 2026/06/19 06:33 [pubmed] PHST- 2026/06/19 00:17 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1186/s40814-026-01850-6 [pii] AID - 1850 [pii] AID - 10.1186/s40814-026-01850-6 [doi] PST - epublish SO - Pilot Feasibility Stud. 2026 Jun 18;12(1):125. doi: 10.1186/s40814-026-01850-6. PMID- 42316104 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260830 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 18 TI - Consumption of ultra-processed foods and associated factors in Spanish children aged 8-12 years: a cross-sectional analysis within the INMA cohort study. LID - 10.1186/s12889-026-28008-6 [doi] LID - 2471 AB - BACKGROUND: The consumption of ultra-processed foods (UPF) has been associated with adverse health effects. The predictors of consumption, particularly in high-intake groups like children and adolescents, are scarcely understood. METHODS: We evaluated UPF consumption and associated factors among male and female Spanish children aged 8-12 years participating in the INMA birth cohort. We cross-sectionally analyzed data from 1565 mother-child pairs at age 8 and 314 pairs at age 12. Children's diets were assessed using validated food frequency questionnaires. UPF consumption was defined using the NOVA classification and categorized into tertiles. The associations between maternal-child characteristics and children's UPF consumption were analyzed using multinomial logistic regression to estimate relative risk ratios (RRR) and 95% confidence intervals (95%CI). RESULTS: At age 8, high UPF consumption was associated with low maternal social class, RRR = 2.22 (1.46-3.37), moderate maternal UPF consumption during pregnancy, RRR = 1.87 (1.35-2.58), high maternal UPF consumption during pregnancy, RRR = 3.47 (2.40-4.99), being male, RRR = 1.76 (1.34-2.30), and high children's TV viewing, RRR = 1.76 (1.19-2.60). At age 12, high UPF consumption was associated with high maternal UPF consumption during pregnancy, RRR = 3.09 (1.27-7.50), and high children's TV viewing, RRR = 2.34 (1.05-5.21), although it was inversely associated with maternal university education, RRR = 0.21 (0.06-0.69), and high children's physical activity, RRR = 0.43 (0.20-0.93). CONCLUSIONS: Maternal factors such as high UPF consumption during pregnancy, low social class and low education level, and low physical activity and TV watching during childhood and adolescence, were predictors of higher UPF consumption at the age of 8 and 12 years. CI - (c) 2026. The Author(s). FAU - Compan-Gabucio, Laura-Maria AU - Compan-Gabucio LM AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. AD - Department of Surgery and Pathology, Miguel Hernandez University, Sant Joan d'Alacant, Valencian Community, Alicante, 03550, Spain. FAU - Oncina-Canovas, Alejandro AU - Oncina-Canovas A AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. FAU - Torres-Collado, Laura AU - Torres-Collado L AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. FAU - Fernandez-Tardon, Guillermo AU - Fernandez-Tardon G AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. AD - Health Research Institute of the Principality of Asturias (ISPA), Asturias, Asturias, Principality of Asturias, Oviedo, 33011, Spain. AD - Faculty of Medicine, Community of Madrid, Universidad Nebrija, Hoyo de Manzanares, Community of Madrid, Madrid, 28015, Spain. FAU - Tardon, Adonina AU - Tardon A AD - Health Research Institute of the Principality of Asturias (ISPA), Asturias, Asturias, Principality of Asturias, Oviedo, 33011, Spain. AD - Faculty of Medicine, Community of Madrid, Universidad Nebrija, Hoyo de Manzanares, Community of Madrid, Madrid, 28015, Spain. FAU - Santa-Marina Rodriguez, Loreto AU - Santa-Marina Rodriguez L AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. FAU - Barroeta, Ziortza AU - Barroeta Z AD - Department of Preventive Medicine and Public Health, University of the Basque Country UPV/EHU, Basque Country, Leioa, Biscay, Basque Country, 48940, Spain. FAU - Vrijheid, Martine AU - Vrijheid M AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. AD - ISGlobal, Barcelona, Catalonia, 08036, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, 08005, Spain. FAU - Warkentin, Sarah AU - Warkentin S AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. AD - ISGlobal, Barcelona, Catalonia, 08036, Spain. AD - Universitat Pompeu Fabra (UPF), Barcelona, Catalonia, 08005, Spain. FAU - Llop, Sabrina AU - Llop S AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. AD - Epidemiology and Environmental Health Joint Research Unit, FISABIO, Valencian Community, Valencian Community, Valencia, 46020, Spain. FAU - Soler-Blasco, Raquel AU - Soler-Blasco R AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. AD - Epidemiology and Environmental Health Joint Research Unit, FISABIO, Valencian Community, Valencian Community, Valencia, 46020, Spain. FAU - Ojeda-Belokon, Carolina AU - Ojeda-Belokon C AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. FAU - Garcia-de-la-Hera, Manuela AU - Garcia-de-la-Hera M AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. FAU - Vioque, Jesus AU - Vioque J AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. vioque@umh.es. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. vioque@umh.es. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. vioque@umh.es. AD - Department of Preventive Medicine and Public Health, University of the Basque Country UPV/EHU, Basque Country, Leioa, Biscay, Basque Country, 48940, Spain. vioque@umh.es. AD - H feminine de la Ciencia y Ginecologia, Facultad de Medicina, Avda. Ramon y Cajal s/n. 03550-Sant Joan d'Alacant, Valencian Community, Alicante, Spain. vioque@umh.es. FAU - Gonzalez-Palacios, Sandra AU - Gonzalez-Palacios S AD - Grupo de Epidemiologia de la Nutricion, Universidad Miguel Hernandez (UMH), Sant Joan d'Alacant, Alicante, Valencian Community, 03550, Spain. AD - Instituto de Investigacion Sanitaria y Biomedica de Alicante (ISABIAL), Valencian Community, Alicante, Valencian Community, 03010, Spain. AD - Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Community of Madrid, Instituto de Salud Carlos III, Community of Madrid, Madrid, 28029, Spain. LA - eng GR - CEX2023-0001290-S/MCIN/AEI/ 10.13039/501100011033, and support from the Generalitat de Catalunya/ GR - 2021 BP 00058/Agency for Management of University and Research Grants with a Beatriu de Pinos post-doctoral fellowship/ GR - CIGE2023/142/Generalitat Valenciana/ GR - PROMETEO-CIPROM/2024/66/Generalitat Valenciana/ GR - grant code PN22_CGE45/General Council of Official Nursing Boards of Spain and the Spanish Institute of Nursing Research/ GR - 04-541-6-2024-0153-N/"Personal Investigador en Formacion" from the "Universidad Miguel Hernandez de Elche"/ GR - PI11/01007/Instituto de Salud Carlos III/ GR - Project PI23/01568/Instituto de Salud Carlos III/ GR - ESP24PI02/2024/Consorcio Centro de Investigacion Biomedica en Red/ PT - Journal Article DEP - 20260618 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Child MH - Female MH - Spain MH - Male MH - Cross-Sectional Studies MH - *Fast Foods/statistics & numerical data MH - *Diet/statistics & numerical data MH - Cohort Studies MH - Birth Cohort PMC - PMC13523201 OTO - NOTNLM OT - Adolescents OT - Birth cohort study OT - Children OT - Determinants OT - Sex-specific OT - Ultra-Processed Foods COIS- Declarations. Ethics approval and consent to participate: All pregnant women provided written informed consent prior to their inclusion in the study. In the case of their offspring, written informed consent was obtained from their parents or legal guardians. The study was conducted in accordance with the principles of the Declaration of Helsinki and its later amendments. The study protocol was approved by the following Ethics Committees: the Clinical Research Ethics Committee of Hospital Universitario La Fe (Valencia, Spain); the Clinical Research Ethics Committee of Area Sanitaria de Gipuzkoa (Gipuzkoa, Spain); the Clinical Research Ethics Committee of Parc de Salut del Mar (Barcelona, Spain); and the Clinical Research Ethics Committee of the Principado de Asturias (Spain). The present work was additionally approved by the Clinical Research Ethics Committee of the Alicante Health Department - Hospital General (Ref.: PI2024-087, June 19, 2024). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/19 06:33 MHDA- 2026/08/28 11:46 PMCR- 2026/06/18 CRDT- 2026/06/19 00:07 PHST- 2026/03/20 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/08/28 11:46 [medline] PHST- 2026/06/19 06:33 [pubmed] PHST- 2026/06/19 00:07 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1186/s12889-026-28008-6 [pii] AID - 28008 [pii] AID - 10.1186/s12889-026-28008-6 [doi] PST - epublish SO - BMC Public Health. 2026 Jun 18;26(1):2471. doi: 10.1186/s12889-026-28008-6. PMID- 42316044 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260829 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jun 18 TI - Machine learning to improve the prediction of Large for Gestational Age (LGA) neonates: a cohort study. LID - 10.1186/s12884-026-09411-8 [doi] LID - 956 AB - BACKGROUND: Prediction of Large for Gestational Age (LGA) risk is important as it can enable earlier, more effective interventions, and avoid or mitigate cumulative injury to both mother and baby at the time of delivery. The goal of this research is to improve the prediction of LGA using machine learning (ML) models and variables that are widely available as that allow for broad intervention in late pregnancy and during delivery. METHODS: An improved prediction of LGA was achieved using twelve ML models with hyperparameter optimization. Also, to improve the LGA prediction a data augmentation method was employed in the training set. Additionally, improvement in LGA prediction was obtained with four variable selection methods employed to identify the most significant variables. To rank the best models on the validation set after training, the Area under the Receiver Operating Characteristic Curve (AUROC) was used. Finally, to assess the generalization performance, the best models were evaluated on the test set. RESULTS: Our method enabled us to identify several models with high sensitivity and specificity. The best models included those that achieved a sensitivity of 0.84, a specificity of 0.84, an accuracy of 0.84, and AUCROC 0.83, requiring 14 variables. Another model reached an accuracy of 0.87, a sensitivity of 0.71, and a specificity of 0.90 with an AUCROC of 0.83 (14 variables). Additionally, a model with a sensitivity of 0.58, the same as that described by Hadlock et al. [1] for ultrasound, required 10 variables, and reached an accuracy of 0.91, a specificity of 0.97, and an AUCROC of 0.86. Both models included maternal BMI (body mass index), First Control, Maternal Weight, BMI Last Control, and EFW (estimated fetal weight) as the most important variables. CONCLUSIONS: The main contributions of our study include the prediction of LGA using data obtained from standard clinical evaluations during prenatal care, as well as the development ML models, tuning the hyperparameters to improve prediction results, thus achieving high levels of sensitivity and specificity. To achieve optimal LGA prediction outcomes across different models, a data augmentation approach is introduced, an important improvement in LGA prediction over using only Hadlock's ultrasound formula. CI - (c) 2026. The Author(s). FAU - Cubillos, Gabriel AU - Cubillos G AD - Department of Electrical Engineering, Universidad de Chile, Av. Tupper 2007, Santiago, 8370451, Chile. AD - IMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Santiago, Chile. FAU - Monckeberg, Max AU - Monckeberg M AD - Department of Obstetrics and Gynecology and Laboratory of Reproductive Biology, Faculty of Medicine, Universidad de los Andes, San Carlos de Apoquindo 2200, Santiago, 7620001, Chile. FAU - Plaza, Alejandra AU - Plaza A AD - Department of Obstetrics and Gynecology and Laboratory of Reproductive Biology, Faculty of Medicine, Universidad de los Andes, San Carlos de Apoquindo 2200, Santiago, 7620001, Chile. FAU - Morgan, Maria AU - Morgan M AD - Department of Obstetrics and Gynecology and Laboratory of Reproductive Biology, Faculty of Medicine, Universidad de los Andes, San Carlos de Apoquindo 2200, Santiago, 7620001, Chile. FAU - Estevez, Pablo A AU - Estevez PA AD - Department of Electrical Engineering, Universidad de Chile, Av. Tupper 2007, Santiago, 8370451, Chile. AD - IMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Santiago, Chile. FAU - Choolani, Mahesh AU - Choolani M AD - Department of Obstetrics and Gynaecology, NUS Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. FAU - Kemp, Matthew W AU - Kemp MW AD - Department of Obstetrics and Gynaecology, NUS Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. FAU - Li, Sarah W L AU - Li SWL AD - Department of Obstetrics and Gynaecology, NUS Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. FAU - Illanes, Sebastian E AU - Illanes SE AD - IMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Santiago, Chile. sillanes@uandes.cl. AD - Department of Obstetrics and Gynecology and Laboratory of Reproductive Biology, Faculty of Medicine, Universidad de los Andes, San Carlos de Apoquindo 2200, Santiago, 7620001, Chile. sillanes@uandes.cl. AD - Department of Obstetrics and Gynaecology, NUS Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 12, Singapore, 119228, Singapore. sillanes@uandes.cl. FAU - Perez, Claudio A AU - Perez CA AD - Department of Electrical Engineering, Universidad de Chile, Av. Tupper 2007, Santiago, 8370451, Chile. clperez@ing.uchile.cl. AD - IMPACT, Center of Interventional Medicine for Precision and Advanced Cellular Therapy, Santiago, Chile. clperez@ing.uchile.cl. LA - eng GR - IMPACT, #FB210024/Agencia Nacional de Investigacion y Desarrollo (ANID)/ PT - Journal Article DEP - 20260618 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Infant, Large for Gestational Age MH - Predictive Learning Models MH - Infant, Newborn MH - *Machine Learning MH - Prediction Algorithms MH - ROC Curve MH - Sensitivity and Specificity MH - Gestational Age MH - Cohort Studies MH - Area Under Curve MH - Adult MH - Classification Algorithms MH - Ultrasonography, Prenatal MH - *Fetal Macrosomia/diagnosis PMC - PMC13520273 OTO - NOTNLM OT - Commonly accessible variables OT - Data augmentation techniques OT - LGA prediction OT - Large for Gestational Age (LGA) OT - Machine learning algorithms OT - Ultrasound COIS- Declarations. Ethics approval and consent to participate: The data usage was approved by the by the institutional review board (IRB) of Hospital Parroquial de San Bernardo, Santiago, Chile, who determined that the research does not involve human subjects because the study uses previously collected, de-identified data. The "Comite de Etica del Hospital Parroquial de San Bernardo" waived the need for informed consent. All methods were carried out in accordance with relevant guidelines and regulations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/19 06:32 MHDA- 2026/08/27 05:35 PMCR- 2026/06/18 CRDT- 2026/06/19 00:05 PHST- 2024/09/17 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/08/27 05:35 [medline] PHST- 2026/06/19 06:32 [pubmed] PHST- 2026/06/19 00:05 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1186/s12884-026-09411-8 [pii] AID - 9411 [pii] AID - 10.1186/s12884-026-09411-8 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jun 18;26(1):956. doi: 10.1186/s12884-026-09411-8. PMID- 42315960 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20261008 IS - 1476-5640 (Electronic) IS - 0954-3007 (Linking) VI - 80 IP - 9 DP - 2026 Sep TI - Comparative machine learning modeling of resting energy expenditure estimation in mechanically ventilated children after cardiac surgery. PG - 949-957 LID - 10.1038/s41430-026-01775-6 [doi] AB - OBJECTIVE: Nutrition status is vital for children's recovery following cardiac surgery, with substantial inter-individual variability in metabolic demands. We aimed to develop machine learning (ML) models of postoperative resting energy expenditure (REE) by analysing the influential factors. METHODS: We retrospectively analyzed children who underwent indirect calorimetry (IC) for valid REE measurements within 4 to 24 h after cardiac surgery between January 2021 and December 2022 at our center. Nine ML algorithms were trained to predict REE. Bland-Altman analysis assessed agreement with measured REE, and SHAP was used for population-level interpretation and a representative patient case. RESULTS: A total of 278 mechanically ventilated children were analyzed. REE measured by IC ranged from 387 to 2642 kcal/d (715 [550, 964]). The root mean square error (RMSE) of the ML models ranged from 226 (95% CI: 184-267) to 281 (95% CI: 225-344) kcal/d, while the range for conventional equations was 249 (95% CI: 215-287) to 282 (95% CI: 252-315) kcal/d. Regularized linear models achieved the highest R(2) of 0.64 (95% CI: 0.49-0.76). The top 10 most important variables associated with REE in the optimal model are weight, age, height, preoperative serum albumin, preoperative CK-MB, vasoactive inotropic score (VIS), CPB time, postoperative LVEDD Z-score, gender, and postoperative NT-proBNP. CONCLUSIONS: This study developed ML models to predict REE in children after cardiac surgery, with some models outperforming conventional equations. These findings highlight the potential of machine learning to optimize postoperative nutritional management by accurately capturing the non-linear metabolic response to surgical stress. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Li, Chenyu AU - Li C AUID- ORCID: 0009-0002-0211-0441 AD - Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Zhu, Zhiyuan AU - Zhu Z AD - Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Wang, Shilin AU - Wang S AD - Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Li, Chao AU - Li C AD - Capital Center for Children's Health, Capital Institute of Pediatrics, Capital Medical University, Beijing, China. FAU - Lu, Zhongyuan AU - Lu Z AD - Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Chen, Qinnan AU - Chen Q AD - Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. FAU - Wang, Xu AU - Wang X AUID- ORCID: 0000-0002-4887-3367 AD - Department of Pediatric Intensive Care Unit, National Center for Cardiovascular Disease and Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. fwpicu@163.com. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260618 PL - England TA - Eur J Clin Nutr JT - European journal of clinical nutrition JID - 8804070 SB - IM MH - Humans MH - Female MH - *Machine Learning MH - *Respiration, Artificial MH - Male MH - *Cardiac Surgical Procedures MH - Retrospective Studies MH - Calorimetry, Indirect MH - Child, Preschool MH - Infant MH - *Basal Metabolism/physiology MH - Postoperative Period MH - Child MH - Nutritional Status MH - Predictive Learning Models MH - *Energy Metabolism COIS- Competing interests: The authors declare no competing interests. Ethical approval: This study was approved by the Ethics Committee of the Fuwai Hospital in 2022 (ID: 2022-1859). This study complied with the ethical principles laid out in the Helsinki Declaration of 1975, as revised in 2008. Informed consent: In this study, the ethics committee approved the waiver of informed consent. EDAT- 2026/06/19 00:36 MHDA- 2026/09/10 05:37 CRDT- 2026/06/18 23:34 PHST- 2025/08/12 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/05/01 00:00 [revised] PHST- 2026/09/10 05:37 [medline] PHST- 2026/06/19 00:36 [pubmed] PHST- 2026/06/18 23:34 [entrez] AID - 10.1038/s41430-026-01775-6 [pii] AID - 10.1038/s41430-026-01775-6 [doi] PST - ppublish SO - Eur J Clin Nutr. 2026 Sep;80(9):949-957. doi: 10.1038/s41430-026-01775-6. Epub 2026 Jun 18. PMID- 42315803 OWN - NLM STAT- MEDLINE DCOM- 20260618 LR - 20260922 IS - 2730-7174 (Electronic) IS - 2730-7166 (Print) IS - 2730-7166 (Linking) VI - 54 IP - 4 DP - 2026 Jun 18 TI - Feasibility and Acceptability of a Smartphone and Wearable Assessment Protocol for Adolescents with Depression. LID - 10.1007/s10802-026-01464-9 [doi] LID - 78 AB - Smartphones and wearables are low-burden tools for assessing real-time mood and behavior. Although these methods have been used with adolescents for behavioral tracking (e.g., activity, sleep), less is known about longer-term use (beyond one week) with adolescents with depression and about mobile sensing for monitoring mood for any adolescent population. This study examined acceptability and feasibility of a one-month EMA, actigraphy, and mobile sensing protocol for adolescents with elevated depressive symptoms. Adolescents aged 12 to 18 (N = 69; Mage = 15.46; 67% assigned female at birth; 42% White; 71% Hispanic or Latine; 38% sexual minority) completed EMA surveys on depressive symptoms, processes, and affect multiple times daily via a smartphone app that also collected passive sensor data (e.g., motion, geolocation). An actigraph measured physical activity and sleep. A feedback interview assessed protocol acceptability. Most participants (91%) completed all components, were willing to participate again (91%), and would recommend participation to peers (93%). EMA response rates improved (mean completion 57% to 66%) after shifting to a semi-personalized schedule with extended response windows. Actigraph wear time was high (> 70%) despite device-related issues. Sensor data availability varied by operating system, and privacy concerns influenced participation. Adherence was correlated within and between modalities, suggesting that individual compliance played a central role in consistent engagement. Findings support the feasibility and acceptability of smartphone and wearable methods for capturing real-world mood and behavior in adolescents, however careful attention to design, engagement, and ethical considerations remains essential. CI - (c) 2026. The Author(s). FAU - Guo, Jenny AU - Guo J AUID- ORCID: 0000-0002-3535-5181 AD - Department of Psychology and Center for Children and Families, Florida International University, Miami, FL, USA. jguo033@fiu.edu. FAU - Frederick, Jennifer AU - Frederick J AUID- ORCID: 0000-0001-9411-4284 AD - Department of Psychology and Center for Children and Families, Florida International University, Miami, FL, USA. FAU - Cunningham, Lindsey AU - Cunningham L AUID- ORCID: 0000-0003-4700-5231 AD - Department of Psychology and Center for Children and Families, Florida International University, Miami, FL, USA. FAU - Jacobson, Nicholas C AU - Jacobson NC AUID- ORCID: 0000-0002-8832-4741 AD - Center for Technology and Behavioral Health, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA. AD - Quantitative Biomedical Sciences Program, Dartmouth College, Hanover, NH, USA. AD - Department of Biomedical Data Science, Geisel School of Medicine, Dartmouth College, Lebanon, NH, USA. AD - Department of Psychiatry, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA. FAU - Fisher, Aaron J AU - Fisher AJ AUID- ORCID: 0000-0001-9754-4618 AD - Department of Psychology, University of California, Berkeley, Berkeley, CA, USA. FAU - Pettit, Jeremy W AU - Pettit JW AUID- ORCID: 0000-0002-7426-9411 AD - Department of Psychology and Center for Children and Families, Florida International University, Miami, FL, USA. FAU - McMakin, Dana L AU - McMakin DL AUID- ORCID: 0000-0002-6954-4204 AD - Department of Psychology and Center for Children and Families, Florida International University, Miami, FL, USA. FAU - Ng, Mei Yi AU - Ng MY AUID- ORCID: 0000-0002-1399-0133 AD - Department of Psychology and Center for Children and Families, Florida International University, Miami, FL, USA. LA - eng GR - R21 MH126394/MH/NIMH NIH HHS/United States GR - R21MH126394/MH/NIMH NIH HHS/United States PT - Journal Article PT - Research Support, U.S. Gov't, P.H.S. DEP - 20260618 PL - United States TA - Res Child Adolesc Psychopathol JT - Research on child and adolescent psychopathology JID - 101773609 SB - IM MH - Humans MH - Female MH - Adolescent MH - *Smartphone MH - Feasibility Studies MH - *Actigraphy/instrumentation MH - Child MH - *Wearable Electronic Devices MH - *Depression/diagnosis MH - Male MH - *Mobile Applications MH - *Ecological Momentary Assessment MH - Sleep MH - Digital Health MH - *Patient Acceptance of Health Care PMC - PMC13279485 OTO - NOTNLM OT - Actigraphy OT - Depressive disorder OT - Ecological momentary assessment OT - Feasibility study OT - Mobile sensing OT - Smartphone COIS- Declarations. Ethical Approval: The study was approved by the Institutional Review Board of Florida International University in April 2020 (IRB-20-0257) and renewed annually thereafter. The study was conducted in accordance with the ethical standards of the American Psychological Association. Informed consent was obtained from all individual participants included in the study. Conflict of Interest: The authors declare that they have no conflicts of interest to disclose. EDAT- 2026/06/19 00:36 MHDA- 2026/06/19 00:37 PMCR- 2026/06/18 CRDT- 2026/06/18 23:26 PHST- 2025/11/24 00:00 [received] PHST- 2026/04/14 00:00 [accepted] PHST- 2026/06/19 00:37 [medline] PHST- 2026/06/19 00:36 [pubmed] PHST- 2026/06/18 23:26 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1007/s10802-026-01464-9 [pii] AID - 1464 [pii] AID - 10.1007/s10802-026-01464-9 [doi] PST - epublish SO - Res Child Adolesc Psychopathol. 2026 Jun 18;54(4):78. doi: 10.1007/s10802-026-01464-9. PMID- 42315727 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261011 IS - 1476-5497 (Electronic) IS - 0307-0565 (Print) IS - 0307-0565 (Linking) VI - 50 IP - 9 DP - 2026 Sep TI - Toward an intergenerational model of metabolic and bariatric surgery: reframing the household as the unit of care. PG - 1893-1898 LID - 10.1038/s41366-026-02131-1 [doi] AB - Obesity is a chronic, relapsing disease that increasingly spans generations within households, yet contemporary metabolic and bariatric surgery (MBS) models remain oriented toward individuals or single-generation patients. A growing body of evidence demonstrates that obesity risk, behaviors, and treatment responses cluster within family systems, and that MBS produces measurable metabolic and behavioral effects among untreated spouses, partners, and children. Concurrently, decades of pediatric research confirm that caregiver engagement and integration is one of the strongest determinants of successful obesity treatment. Together, these observations support a paradigm shift toward an intergenerational, family-centered model of MBS, in which the household becomes the unit of care. This perspective synthesizes evidence supporting the biological, behavioral, and environmental interdependence of obesity within families and outlines a comprehensive framework for implementing household-level bariatric care. Core components include integrated pediatric-adult clinical infrastructure; combined multidisciplinary teams trained across the age spectrum; harmonized protocols for evaluation, education, and follow-up; coordinated scheduling and workflow alignment; and family-based behavioral strategies that promote shared goals, consistent routines, and mutual accountability. Operational and policy innovations, such as cross-departmental agreements, unified electronic health records, and coordinated billing can facilitate sustainable implementation. We further identify research priorities, including quantifying metabolic ripple effects among untreated family members, evaluating bundled household-level interventions, and developing validated metrics to assess changes in the home environment. Treating the household as the patient offers a promising strategy to enhance medical obesity treatment, surgical durability, improve adherence, and disrupt intergenerational transmission of obesity. As obesity increasingly presents as a family condition, an intergenerational MBS model may help realign treatment with the realities of lived experience and improve outcomes across generations. CI - (c) 2026. The Author(s). FAU - Vidmar, Alaina P AU - Vidmar AP AUID- ORCID: 0000-0003-3790-6255 AD - Department of Pediatrics, Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles and Keck School of Medicine of USC, Los Angeles, CA, USA. avidmar@chla.usc.edu. FAU - Samakar, Kamran AU - Samakar K AUID- ORCID: 0000-0002-1710-6245 AD - Division of Pediatric Surgery, Department of Surgery, Children's Hospital Los Angeles and Keck School of Medicine of USC,, Los Angeles, CA, USA. AD - Division of Upper Gastrointestinal and General Surgery, Department of Surgery, Keck Medical Center of University of Southern California, Los Angeles, CA, USA. FAU - Martin, Matthew J AU - Martin MJ AD - Division of Pediatric Surgery, Department of Surgery, Children's Hospital Los Angeles and Keck School of Medicine of USC,, Los Angeles, CA, USA. AD - Division of Upper Gastrointestinal and General Surgery, Department of Surgery, Keck Medical Center of University of Southern California, Los Angeles, CA, USA. FAU - Morton, John Magana AU - Morton JM AD - Department of Surgery, Yale School of Medicine, New Haven, CT, USA. LA - eng PT - Journal Article PT - Review DEP - 20260618 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM MH - Humans MH - *Bariatric Surgery MH - Child MH - *Intergenerational Relations MH - *Obesity/surgery MH - Female PMC - PMC13649551 COIS- Competing interests: The authors have no pertinent financial interests/personal relationships relevant to the submitted manuscript. Financial interests/personal relationships not relevant to the submitted manuscript include: APV: Soleno Pharmaceuticals: consulting; Lilly and Company: funding research grant; Rhythm Pharmaceuticals: funding research grant. All other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/19 00:36 MHDA- 2026/10/09 05:30 PMCR- 2026/06/18 CRDT- 2026/06/18 23:23 PHST- 2026/02/17 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/05/05 00:00 [revised] PHST- 2026/10/09 05:30 [medline] PHST- 2026/06/19 00:36 [pubmed] PHST- 2026/06/18 23:23 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1038/s41366-026-02131-1 [pii] AID - 2131 [pii] AID - 10.1038/s41366-026-02131-1 [doi] PST - ppublish SO - Int J Obes (Lond). 2026 Sep;50(9):1893-1898. doi: 10.1038/s41366-026-02131-1. Epub 2026 Jun 18. PMID- 42315306 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260902 IS - 1535-5667 (Electronic) IS - 0161-5505 (Linking) VI - 67 IP - 9 DP - 2026 Sep 2 TI - Pediatric Reference Ranges for Glomerular Filtration Rate Determined by a Single Injection of (99m)Tc-DTPA. PG - 1469-1473 LID - 10.2967/jnumed.125.271392 [doi] AB - Determination of glomerular filtration rate (GFR) with (99m)Tc-labeled diethylenetriaminepentaacetic acid ((99m)Tc-DTPA) is a validated method to assess renal function, but there are no well-established pediatric reference ranges for GFR. The aim of this study was to establish reference GFRs in children and young adults. Methods: GFR was calculated for 235 reference subjects (median age, 4.86 y; range, 20 d to 24.8 y) using (99m)Tc-DTPA at Boston Children's Hospital between 2000 and 2020. This included 220 patients for prechemotherapy evaluation and 15 potential kidney donors. GFR was determined using a single-compartment model after a single intravenous injection technique and serial blood sampling at 2, 3, and 4 h. Data were analyzed by age, corrected for body surface area, and normalized to a body surface area of 1.73 m(2) The 95% reference ranges were calculated as mean +/- 1.96 SD. Results: GFR increased with age, likely reflecting increased functional renal mass. Lower normalized GFR in children younger than 1 y may reflect renal immaturity. Conclusion: The use of a single injection of (99m)Tc-DTPA revealed that GFR increases with age, likely reflecting increased renal mass. Further, in patients younger than 1 y, GFR rapidly increases initially, with a subsequent more gradual increase, reaching the adult level by approximately 2 y of age. Between 2 and 10 y of age, the GFR slightly exceeds the adult level, stabilizing at a slightly lower adult level by 10 y of age. CI - (c) 2026 by the Society of Nuclear Medicine and Molecular Imaging. FAU - Zukotynski, Katherine A AU - Zukotynski KA AD - Department of Medical Imaging, University of Toronto, Toronto, Ontario, Canada; katherine.zukotynski@utoronto.ca. AD - Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada. AD - Department of Diagnostic and Interventional Radiology, Roswell Park Comprehensive Cancer Center, Buffalo, New York. FAU - Grant, Frederick D AU - Grant FD AD - Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. FAU - Du, Leanne AU - Du L AD - Department of Medical Imaging, Gold Coast University Hospital, Southport, Queensland, Australia. FAU - Hsiao, Edward AU - Hsiao E AD - Melanoma Institute Australia, University of Sydney, Sydney, New South Wales, Australia. AD - Royal North Shore Hospital, Sydney, New South Wales, Australia. FAU - Zurakowski, David AU - Zurakowski D AD - Boston Children's Hospital, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts; and. FAU - Valencia, Valentina Ferrer AU - Valencia VF AD - Boston Children's Hospital, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts; and. FAU - Treves, S Ted AU - Treves ST AD - Harvard Medical School, Boston, Massachusetts; and. AD - Brigham and Women's Hospital, Boston, Massachusetts. FAU - Fahey, Frederic H AU - Fahey FH AD - Boston Children's Hospital, Boston, Massachusetts. AD - Harvard Medical School, Boston, Massachusetts; and. LA - eng PT - Journal Article DEP - 20260902 PL - United States TA - J Nucl Med JT - Journal of nuclear medicine : official publication, Society of Nuclear Medicine JID - 0217410 RN - VW78417PU1 (Technetium Tc 99m Pentetate) RN - 0 (Radiopharmaceuticals) SB - IM MH - Humans MH - *Technetium Tc 99m Pentetate/administration & dosage MH - *Glomerular Filtration Rate MH - Reference Values MH - Child, Preschool MH - Child MH - Female MH - Male MH - Infant MH - Adolescent MH - Young Adult MH - Kidney Function Tests/standards MH - Infant, Newborn MH - Radiopharmaceuticals/administration & dosage OTO - NOTNLM OT - 99mTc-DTPA OT - glomerular filtration rate OT - pediatric reference ranges OT - renal function OT - single-injection technique EDAT- 2026/06/19 00:36 MHDA- 2026/09/03 01:19 CRDT- 2026/06/18 21:33 PHST- 2026/01/05 00:00 [received] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/09/03 01:19 [medline] PHST- 2026/06/19 00:36 [pubmed] PHST- 2026/06/18 21:33 [entrez] AID - jnumed.125.271392 [pii] AID - 10.2967/jnumed.125.271392 [doi] PST - epublish SO - J Nucl Med. 2026 Sep 2;67(9):1469-1473. doi: 10.2967/jnumed.125.271392. PMID- 42315145 OWN - NLM STAT- Publisher LR - 20260618 IS - 1741-2889 (Electronic) IS - 1367-4935 (Linking) DP - 2026 Jun 18 TI - Validation of a parent-report version of the Emotional Eating Scale Adapted for Children and Adolescents Short-Form in American mothers. PG - 13674935261459838 LID - 10.1177/13674935261459838 [doi] AB - Emotional eating is associated with negative outcomes in children, including elevated weight status and disordered eating. The current study assessed the preliminary psychometric properties of a 10-item parent-report version of the Emotional Eating Scale Adapted for Children (EES-C) Short-Form. Participants were 324 mothers of children ages 5-12 years. The parent-report version of the EES-C Short-Form and the Child Feeding Questionnaire were administered to mothers in the United States online. Cronbach's alpha for the parent-report version of the EES-C-Short-Form was in the excellent range (alpha = .94). Mothers reported significantly higher levels of emotional eating in overweight/obese children than healthy weight children eating (effect size = 0.45, p < .001). Maternal reports of their child's emotional eating on the EES-C-Short-Form were associated with maternal concern about their child's weight (r = .285; 95% confidence interval = .18-.39), restricted eating (r = .238; 95% confidence interval = .13-.35), and monitoring of their child's food intake (r = .136; 95% confidence interval = .02-.25) on the Child Feeding Questionnaire, supporting convergent validity. A unidimensional model produced a good fit (chi(2) (35) = 70.31, p = 0.00, CFI = .999, SRMR = .036). Taken as a whole, this study provides preliminary support for the reliability and validity of the parent version of the EES-C Short-Form. FAU - Summers, Emma AU - Summers E AUID- ORCID: 0009-0003-2562-5189 AD - Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA. RINGGOLD: 14643 FAU - Limbers, Christine A AU - Limbers CA AUID- ORCID: 0000-0002-4880-1865 AD - Department of Psychology and Neuroscience, Baylor University, Waco, TX, USA. RINGGOLD: 14643 LA - eng PT - Journal Article DEP - 20260618 PL - England TA - J Child Health Care JT - Journal of child health care : for professionals working with children in the hospital and community JID - 9806360 SB - IM OTO - NOTNLM OT - child OT - emotional eating OT - parents OT - psychometrics EDAT- 2026/06/19 00:36 MHDA- 2026/06/19 00:36 CRDT- 2026/06/18 19:53 PHST- 2026/06/19 00:36 [medline] PHST- 2026/06/19 00:36 [pubmed] PHST- 2026/06/18 19:53 [entrez] AID - 10.1177/13674935261459838 [doi] PST - aheadofprint SO - J Child Health Care. 2026 Jun 18:13674935261459838. doi: 10.1177/13674935261459838. PMID- 42314901 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20260918 IS - 2212-2672 (Print) IS - 2212-2672 (Linking) VI - 126 IP - 10 DP - 2026 Oct TI - Construct and Criterion Validity of the Comprehensive Food Skills Questionnaire. PG - 156396 LID - S2212-2672(26)00111-5 [pii] LID - 10.1016/j.jand.2026.156396 [doi] AB - BACKGROUND: Increased implementation of teaching kitchens requires a tool with adequate psychometric properties for assessing food skills. One such tool is the 39-item Food Skills Questionnaire, with established face and content validity, and interitem and test-retest reliability. Recently, 8 items were added to create the Comprehensive Food Skills Questionnaire (CFSQ), requiring further validation. OBJECTIVE: The objective of this study was to assess the construct and criterion validity of the CFSQ. DESIGN: This study used a pre-post study design. PARTICIPANTS/SETTING: Year 1 (n = 234; September 2023 and January 2024) and 2 (n = 88; September 2022) students in foods and nutrition courses at a Canadian university completed the CFSQ precourse, with n = 177 (December 2023 and April 2024) and n = 80 postcourse responses (April 2023), respectively. MAIN OUTCOME MEASURES: The primary outcome was total food skills, assessed in 3 domains: Food Selection and Planning, Food Preparation, and Food Safety and Storage. STATISTICAL ANALYSIS: t Tests and analyses of variance were used to test known-group construct validity, and criterion validity was assessed using a 1-sample t test, Bland-Altman plot, and linear regression. RESULTS: Total food skills (mean +/- SD) were significantly higher in known groups: women vs men (Year 1, 70.1 +/- 11.5 vs 63.0 +/- 14.7, respectively; P = .02); those with vs without a previous foods/nutrition/cooking course (Year 1, 70.2 +/- 11.3 vs 66.3 +/- 14.0, respectively; P = .048); primary vs nonprimary cooks (Year 1, 74.1 +/- 12.2 vs 66.5 +/- 11.5; P < .001; Year 2, 80.8 +/- 9.4 vs 69.4 +/- 14.1, respectively; P < .001), greater vs less teen meal preparation (Year 1, 74.4 +/- 11.5 vs 64.1 +/- 12.5, respectively; P < .001; Year 2, 80.2 +/- 9.3 vs 67.9 +/- 17.2, respectively; P < .01), and post- vs precourse (Year 1, 71.8 +/- 11.5 vs 68.9 +/- 12.1; P < .001 and Year 2, 82.1 +/- 9.8 vs 76.0 +/- 12.8; P < .001, respectively). A hypothesized group, greater vs less teen grocery shopping, was also significantly higher (Year 1, 73.8 +/- 10.4 vs 64.3 +/- 12.2; P < .001 and Year 2, 78.7 +/- 10.0 vs 65.5 +/- 17.4 ; P < .01, respectively). A 1-sample t test comparing the mean difference of total food skills and course evaluations (-0.89 +/- 13.4) to 0 was not significant (P = .58). Bland-Altman plot and linear regression (unstandardized beta coefficient = -.084; P = .71) indicated no proportional bias. CONCLUSIONS: The CFSQ demonstrates good construct and criterion validity and is appropriate for assessing food skills in research or practice-based teaching kitchens. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Ulloa, Tahlia AU - Ulloa T AD - Community Health Centres of Northumberland, Port Hope, Ontario, Canada. FAU - Wang, Jinghan AU - Wang J AD - Brescia School of Food and Nutritional Sciences, Faculty of Health Sciences, Western University, London, Ontario, Canada. FAU - Yang, Ying Tong AU - Yang YT AD - Seasons Care Inc, Tecumseh, Ontario, Canada. FAU - Dworatzek, Paula D N AU - Dworatzek PDN AD - Brescia School of Food and Nutritional Sciences, Faculty of Health Sciences, Western University, London, Ontario, Canada. Electronic address: pdworatz@uwo.ca. LA - eng PT - Journal Article PT - Validation Study DEP - 20260618 PL - United States TA - J Acad Nutr Diet JT - Journal of the Academy of Nutrition and Dietetics JID - 101573920 SB - IM MH - Humans MH - Female MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Male MH - Psychometrics MH - Young Adult MH - *Cooking MH - Canada MH - Adult MH - Food Preferences MH - Food Safety MH - Students/statistics & numerical data/psychology MH - Food Handling MH - *Nutritional Sciences/education OTO - NOTNLM OT - Culinary medicine OT - Food literacy OT - Food skills OT - Teaching kitchen OT - Validity EDAT- 2026/06/19 00:36 MHDA- 2026/09/18 23:36 CRDT- 2026/06/18 19:31 PHST- 2025/03/20 00:00 [received] PHST- 2026/02/17 00:00 [revised] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/09/18 23:36 [medline] PHST- 2026/06/19 00:36 [pubmed] PHST- 2026/06/18 19:31 [entrez] AID - S2212-2672(26)00111-5 [pii] AID - 10.1016/j.jand.2026.156396 [doi] PST - ppublish SO - J Acad Nutr Diet. 2026 Oct;126(10):156396. doi: 10.1016/j.jand.2026.156396. Epub 2026 Jun 18. PMID- 42314767 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20260916 IS - 1678-4782 (Electronic) IS - 0021-7557 (Print) IS - 0021-7557 (Linking) VI - 102 IP - 5 DP - 2026 Sep-Oct TI - Evaluation of ChatGPT's reliability in answering questions about short stature and growth failure. PG - 101577 LID - S0021-7557(26)00079-3 [pii] LID - 10.1016/j.jped.2026.101577 [doi] LID - 101577 AB - OBJECTIVE: To evaluate ChatGPT's performance in responding to questions related to short stature and growth failure, which are common concerns in clinical practice. METHODS: Answers provided by the GPT-4 and GPT-4o models to a 36-item questionnaire administered at three different time points (baseline, after 3 months, and after 1 year) were assessed. Each response was rated on a 0-6 Likert scale according to their agreement with those given by pediatric endocrinology specialists. RESULTS: ChatGPT showed an overall satisfactory performance, with high agreement in conceptual questions and in respect of common causes, but lower accuracy in diagnostic and therapeutic topics that require more specialized knowledge. The mean score was 4.6 (SD = 1.3), with a mode of 6. Using a threshold of scores 3-6 as correct, 96.9% of responses were classified as satisfactory; applying stricter thresholds of scores 4-6 and 5-6 yielded rates of 77.2% and 46.3%, respectively. An improvement was observed after the update to GPT-4o, suggesting model evolution over time. However, there was a significant decrease in recommendations to seek medical care in the more recent model. CONCLUSION: ChatGPT demonstrated high reliability and potential as a supportive tool for issues related to short stature; however, its lower accuracy in therapeutic topics and reduced emphasis on the importance of seeking professional medical advice highlight the need for further improvements to ensure its safe use in healthcare. Both professionals and lay users be aware of the limitations of AI and verify information through reliable medical sources. CI - Copyright (c) 2026 The Authors. Published by Elsevier Espana S.L.U. All rights reserved. FAU - Avancini, Rebeca Cricca AU - Avancini RC AD - Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo, SP, Brazil. Electronic address: rebecaca26@gmail.com. FAU - Longui, Carlos Alberto AU - Longui CA AD - Faculdade de Ciencias Medicas da Santa Casa de Sao Paulo, SP, Brazil. Electronic address: carloslongui@msn.com. LA - eng PT - Journal Article DEP - 20260702 PL - Brazil TA - J Pediatr (Rio J) JT - Jornal de pediatria JID - 2985188R SB - IM MH - Humans MH - Reproducibility of Results MH - Surveys and Questionnaires MH - *Growth Disorders/diagnosis MH - Child MH - Female MH - Male MH - Generative Artificial Intelligence MH - *Failure to Thrive/diagnosis PMC - PMC13352365 OTO - NOTNLM OT - AI OT - ChatGPT OT - Pediatric endocrinology OT - Short stature COIS- Conflicts of interest Nothing to declare. EDAT- 2026/06/19 00:36 MHDA- 2026/09/16 23:34 PMCR- 2026/07/02 CRDT- 2026/06/18 19:21 PHST- 2026/03/20 00:00 [received] PHST- 2026/05/24 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/09/16 23:34 [medline] PHST- 2026/06/19 00:36 [pubmed] PHST- 2026/06/18 19:21 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - S0021-7557(26)00079-3 [pii] AID - 101577 [pii] AID - 10.1016/j.jped.2026.101577 [doi] PST - ppublish SO - J Pediatr (Rio J). 2026 Sep-Oct;102(5):101577. doi: 10.1016/j.jped.2026.101577. Epub 2026 Jul 2. PMID- 42313808 OWN - NLM STAT- MEDLINE DCOM- 20260618 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - Implementation research to develop and optimize delivery models for evidence-based anemia control interventions in India: Protocol for the precision-driven response for anemia control and sustainable health (PRAKASH) study. PG - e0351414 LID - 10.1371/journal.pone.0351414 [doi] LID - e0351414 AB - BACKGROUND: Government of India launched Anemia Mukt Bharat (AMB) program in 2018. Despite its implementation, the prevalence of anemia remains high. To address the gaps in coverage, adherence and effective implementation, the Indian Council of Medical Research (ICMR) initiated the Precision driven Response for Anemia Control and Sustainable Health (PRAKASH) study. It is an implementation research study aimed at co-developing and optimizing a district-level model of evidence-based anemia control interventions. The intended goal is to reduce anemia prevalence to 20% or lower through scalable, context-specific, and sustainable strategies. METHODS: This multi-site study targets six key population groups: children (aged 6-59 months and 5-9 years), adolescents boys and girls (10-19 years), women of reproductive age (20-49 years) and pregnant women. Interventions are anchored in six pillar i. Test-Treat-Track until resolution, ii. prophylactic iron and folic acid supplementation, ensuring high complianceiii. anemia-relevant health interventions, iv. fortified rice distribution, v. dietary diversification and promotion of iron-rich foods, and vi. behavior change communication through Jan Andolan. Anemia prevalence will be estimated through a series of community-based cross-sectional surveys. Mixed methods approach will be employed to assess barriers and enablers at the individual, household, facility, and community levels. The study will utilize implementation science frameworks, including Consolidated Framework for Implementation Research (CFIR) and Expert Recommendations for Implementing Change (ERIC), to guide iterative implementation, real-time model refinement, and monitoring of performance. Information on outcome indicators will be collected to evaluate anemia prevalence, fidelity, feasibility, and service delivery improvements. CONCLUSION: The study will try to readdress the implementation challenges across diverse regions and aims to develop a comprehensive and replicable model for the AMB 2.0 program. The study is likely to contribute to the global evidence base on implementation science for anemia reduction in low- and middle-income countries. CI - Copyright: (c) 2026 Bansal et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Bansal, Priyanka Gupta AU - Bansal PG AUID- ORCID: 0000-0002-1058-0956 AD - Division of Reproductive, Child Health and Nutrition, Indian Council of Medical Research, New Delhi, India. FAU - Mazumder, Sarmila AU - Mazumder S AD - Society for Applied Studies, New Delhi, India. FAU - Sharma, Neeraj AU - Sharma N AUID- ORCID: 0000-0003-1006-6321 AD - Society for Applied Studies, New Delhi, India. FAU - Kulkarni, Ragini AU - Kulkarni R AD - Department of Operational and Implementation Research, Indian Council of Medical Research - National Institute for Research in Reproductive and Child Health, Mumbai, Maharashtra, India. FAU - Thankachan, Prashanth AU - Thankachan P AD - Division of Nutrition, St. John's Research Institute, Bangalore, Karnataka, India. FAU - Prasad, Pankaj AU - Prasad P AD - Department of Community and Family Medicine, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India. FAU - Panda, Bhuputra AU - Panda B AD - School of Public Health, KIIT Deemed to be University, Bhubaneswar, Odisha, India. FAU - Banjara, Santosh Kumar AU - Banjara SK AUID- ORCID: 0000-0002-0893-9552 AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, Telangana, India. FAU - Kulkarni, Bharati AU - Kulkarni B AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, Telangana, India. FAU - Chowdhury, Ranadip AU - Chowdhury R AD - Society for Applied Studies, New Delhi, India. FAU - Chandiok, Ketaki AU - Chandiok K AD - Division of Reproductive, Child Health and Nutrition, Indian Council of Medical Research, New Delhi, India. CN - Zaozianlungliu Gonmei CN - PRAKASH Study Group LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260618 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 935E97BOY8 (Folic Acid) RN - E1UOL152H7 (Iron) SB - IM MH - Adolescent MH - Adult MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Middle Aged MH - Pregnancy MH - Young Adult MH - *Anemia/prevention & control/epidemiology MH - Dietary Supplements MH - Folic Acid MH - India/epidemiology MH - Iron MH - Prevalence MH - Multicenter Studies as Topic MH - Observational Studies as Topic PMC - PMC13278398 COIS- The authors have declared that no competing interests exist. EDAT- 2026/06/18 18:32 MHDA- 2026/06/18 18:33 PMCR- 2026/06/18 CRDT- 2026/06/18 13:42 PHST- 2025/12/16 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/06/18 18:33 [medline] PHST- 2026/06/18 18:32 [pubmed] PHST- 2026/06/18 13:42 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - PONE-D-25-62936 [pii] AID - 10.1371/journal.pone.0351414 [doi] PST - epublish SO - PLoS One. 2026 Jun 18;21(6):e0351414. doi: 10.1371/journal.pone.0351414. eCollection 2026. PMID- 42313740 OWN - NLM STAT- MEDLINE DCOM- 20260618 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - The validity and reliability of a biometrically accurate, photorealistic set of young adult body size scales based on 3D scans of White Europeans. PG - e0351658 LID - 10.1371/journal.pone.0351658 [doi] LID - e0351658 AB - Young adults are a high-risk group for weight-related health problems but are often overlooked in weight management intervention design. Validated visual tools that accurately depict body size are needed to improve communication and intervention strategies. This study validated innovative, photo-realistic, gender-specific body size scales of young adults (aged 18), created from 3D scans to depict systematic changes in adiposity. A total of 110 young adults (aged 18-25) completed two behavioural tasks: (1) estimating the relative size of the bodies and (2) ranking them in ascending order of weight. To assess reliability, participants repeated the tasks three days later. Participants accurately estimated relative body sizes and ranked the images in line with the systematic BMI changes across the scales. Test-retest analyses showed good to excellent reliability for both tasks. The young adult body size scales are anthropometrically accurate, reliable, and valid tools for body size estimation tasks. They provide a robust resource for research, clinical communication, and intervention design focused on young adults. CI - Copyright: (c) 2026 Ridley et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Ridley, Bethany J AU - Ridley BJ AD - Department of Psychology, Northumbria University, Newcastle upon Tyne, United Kingdom. FAU - Cornelissen, Piers L AU - Cornelissen PL AD - Department of Psychology, Northumbria University, Newcastle upon Tyne, United Kingdom. FAU - Kramer, Robin S S AU - Kramer RSS AD - School of Psychology, Sport Science and Wellbeing, University of Lincoln, Lincoln, United Kingdom. FAU - Maalin, Nadia AU - Maalin N AUID- ORCID: 0000-0001-7055-1658 AD - Department of Psychology and Counselling, Birmingham City University, Birmingham, United Kingdom. FAU - Mohamed, Sophie AU - Mohamed S AD - Aberdeen Royal Infirmary, NHS Grampian, Aberdeen, United Kingdom. FAU - Tovee, Martin J AU - Tovee MJ AUID- ORCID: 0000-0001-9642-4462 AD - Department of Psychology, Northumbria University, Newcastle upon Tyne, United Kingdom. LA - eng PT - Journal Article PT - Validation Study DEP - 20260618 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - Male MH - *Body Size MH - Young Adult MH - Adult MH - Adolescent MH - Reproducibility of Results MH - *Imaging, Three-Dimensional/methods MH - White People MH - Body Mass Index MH - *Anthropometry/methods PMC - PMC13278476 COIS- The authors have declared that no competing interests exist. EDAT- 2026/06/18 18:33 MHDA- 2026/06/18 18:34 PMCR- 2026/06/18 CRDT- 2026/06/18 13:33 PHST- 2025/10/23 00:00 [received] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/06/18 18:34 [medline] PHST- 2026/06/18 18:33 [pubmed] PHST- 2026/06/18 13:33 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - PONE-D-25-54538 [pii] AID - 10.1371/journal.pone.0351658 [doi] PST - epublish SO - PLoS One. 2026 Jun 18;21(6):e0351658. doi: 10.1371/journal.pone.0351658. eCollection 2026. PMID- 42312671 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260910 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Jun 18 TI - Development and validation of the Brazilian Dietary Guidelines Adherence Score (BraScore): a novel index to assess the adherence to the Dietary Guidelines for the Brazilian Population. PG - e141 LID - 10.1017/S1368980026102936 [doi] LID - e141 AB - OBJECTIVE: We aimed to describe the development and evaluation of the Brazilian Dietary Guidelines Adherence Score (BraScore). DESIGN: The process comprised multiple steps: defining guiding principles, identifying food components, setting scoring cut-off points and assessing validity and reliability. SETTING: Nationally representative sample of the Brazilian population. PARTICIPANTS: 46 164 Brazilians aged >/= 10 years. RESULTS: The BraScore has ten components: to be consumed (legumes; fruits; vegetables and diversity), to be limited (red meat; other animal-based foods; processed foods; table sugar and cooking salt) and to be avoided (ultra-processed foods). Scores range from 0 to 100, with higher values indicating greater adherence to the Dietary Guidelines. Analyses showed a weak correlation with energy intake (coefficient: -0.12) and substantial variability among individuals (1st percentile: 20.5; 99th: 77.7). Scree plot analysis revealed multidimensionality, indicating four distinct patterns. The scores differentiated population groups (older adults and rural residents had higher scores) and were high for diets developed by nutritionists (84.6-97.6 points). The reliability analysis yielded a coefficient of 0.6, suggesting acceptable internal consistency. CONCLUSIONS: The BraScore is a valid and reliable tool to assess adherence to the Dietary Guidelines for the Brazilian Population. FAU - Souza, Thays Nascimento AU - Souza TN AUID- ORCID: 0000-0001-5405-5398 AD - Department of Nutrition, https://ror.org/036rp1748University of Sao Paulo, Brazil. AD - https://ror.org/036rp1748Centre for Epidemiological Research in Nutrition and Health at the University of Sao Paulo (NUPENS/USP), Brazil. AD - Programa de Pos Graduacao em Nutricao em Saude Publica, Faculdade de Saude Publica, https://ror.org/036rp1748Universidade de Sao Paulo, Brazil. FAU - Gabe, Kamila Tiemann AU - Gabe KT AUID- ORCID: 0000-0001-5138-9552 AD - Department of Nutrition, https://ror.org/036rp1748University of Sao Paulo, Brazil. AD - https://ror.org/036rp1748Centre for Epidemiological Research in Nutrition and Health at the University of Sao Paulo (NUPENS/USP), Brazil. AD - Programa de Pos Graduacao em Nutricao em Saude Publica, Faculdade de Saude Publica, https://ror.org/036rp1748Universidade de Sao Paulo, Brazil. FAU - Cacau, Leandro Teixeira AU - Cacau LT AUID- ORCID: 0000-0003-1681-5960 AD - Department of Nutrition, https://ror.org/036rp1748University of Sao Paulo, Brazil. AD - https://ror.org/036rp1748Centre for Epidemiological Research in Nutrition and Health at the University of Sao Paulo (NUPENS/USP), Brazil. AD - Programa de Pos Graduacao em Nutricao em Saude Publica, Faculdade de Saude Publica, https://ror.org/036rp1748Universidade de Sao Paulo, Brazil. FAU - Carneiro, Leticia Barroso Vertulli AU - Carneiro LBV AUID- ORCID: 0000-0003-0832-2293 AD - Universidade Federal do Rio de Janeiro, Instituto de Estudos em Saude Coletiva, Brazil. FAU - Lassale, Camille AU - Lassale C AD - Barcelona Institute for Global Health, Spain. AD - Pompeu Fabra University, Spain. AD - Instituto de Salud Carlos III, Spain. FAU - Levy, Renata Bertazzi AU - Levy RB AUID- ORCID: 0000-0001-5388-7002 AD - https://ror.org/036rp1748Centre for Epidemiological Research in Nutrition and Health at the University of Sao Paulo (NUPENS/USP), Brazil. AD - Department of Preventive Medicine, University of Sao Paulo, Brazil. AD - Institute for Biomedical Research of Salamanca, Spain. FAU - Castro, Ines Rugani Ribeiro de AU - Castro IRR AD - Universidade Estadual do Rio de Janeiro, Brazil. FAU - Louzada, Maria Laura da Costa AU - Louzada MLDC AD - Department of Nutrition, https://ror.org/036rp1748University of Sao Paulo, Brazil. AD - https://ror.org/036rp1748Centre for Epidemiological Research in Nutrition and Health at the University of Sao Paulo (NUPENS/USP), Brazil. AD - Programa de Pos Graduacao em Nutricao em Saude Publica, Faculdade de Saude Publica, https://ror.org/036rp1748Universidade de Sao Paulo, Brazil. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20260618 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Brazil MH - *Nutrition Policy MH - Female MH - Adult MH - Reproducibility of Results MH - Middle Aged MH - Male MH - Child MH - *Diet/standards/statistics & numerical data MH - Young Adult MH - Adolescent MH - *Guideline Adherence/statistics & numerical data MH - Aged MH - *Diet Surveys MH - Energy Intake PMC - PMC13434578 OTO - NOTNLM OT - Diet index OT - Food guide OT - Healthy eating indices OT - Nutritional epidemiology OT - Ultra-processed foods COIS- There are no conflicts of interest. EDAT- 2026/06/18 12:33 MHDA- 2026/07/11 01:09 PMCR- 2026/06/18 CRDT- 2026/06/18 07:34 PHST- 2026/07/11 01:09 [medline] PHST- 2026/06/18 12:33 [pubmed] PHST- 2026/06/18 07:34 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - S1368980026102936 [pii] AID - 10.1017/S1368980026102936 [doi] PST - epublish SO - Public Health Nutr. 2026 Jun 18;29(1):e141. doi: 10.1017/S1368980026102936. PMID- 42312484 OWN - NLM STAT- Publisher LR - 20260618 IS - 1557-1246 (Electronic) IS - 1087-0547 (Linking) DP - 2026 Jun 18 TI - Association of Inflammatory Biomarkers With ADHD and Moderating Effect of Leisure-Time Physical Activity in Adolescents: A Cross-Sectional Study Based on NHANES. PG - 10870547261458103 LID - 10.1177/10870547261458103 [doi] AB - INTRODUCTION: Research findings on specific inflammatory markers (e.g., CRP) in ADHD show considerable heterogeneity. Meanwhile, the potential moderating role of leisure-time physical activity (LTPA) in this relationship is underexplored. METHODS: Based on data from the National Health and Nutrition Examination Survey (NHANES) conducted between 1999 and 2004, 4,817 adolescents aged 12 to 19 were included. This study used logistic regression analysis and restricted cubic splines (RCS) to explore the association between inflammatory biomarkers and ADHD. Interactive analyses were performed to assess the moderating effect of LTPA on this relationship. Furthermore, subgroup analyses were conducted to validate the robustness of the observed effects. RESULTS: After adjusting for all confounding factors, each 1 mg/L increment in C-reactive protein (CRP) was associated with a 9% higher ADHD risk (OR = 1.09, 95% CI [1.01, 1.18]). The chronic low-grade inflammation (CLGI) group exhibited a 57% higher risk of ADHD (OR = 1.57, 95% CI [1.14, 2.15]) compared to the non-GLGI group. The non-linear analysis further revealed that the risk of ADHD reached its peak when CRP was 2.75 mg/L (OR = 1.89, 95% CI [1.39, 2.57]). Compared with the group engaging in less than 60 min of LTPA daily, the association between ADHD and CRP was moderated in the "LTPA >/=60 min/day" group (p for interaction = .04). CONCLUSIONS: Elevated CRP levels are positively associated with ADHD. More than 60 min/day LTPA may moderate the association between CRP and the risk of ADHD. FAU - Pan, Keyu AU - Pan K AUID- ORCID: 0009-0004-9716-7970 AD - School of Exercise and Health, Shanghai University of Sport, China. FAU - Jin, Shanru AU - Jin S AD - School of Exercise and Health, Shanghai University of Sport, China. FAU - Gao, Xiang AU - Gao X AD - School of Exercise and Health, Shanghai University of Sport, China. FAU - He, Changshuang AU - He C AD - School of Exercise and Health, Shanghai University of Sport, China. FAU - Shi, Beibei AU - Shi B AD - School of Exercise and Health, Shanghai University of Sport, China. AD - School of Physical Education, Shandong University, China. FAU - Zhang, Meng AU - Zhang M AD - School of Exercise and Health, Shanghai University of Sport, China. FAU - Wei, Yiting AU - Wei Y AD - School of Exercise and Health, Shanghai University of Sport, China. FAU - Quan, Minghui AU - Quan M AD - School of Exercise and Health, Shanghai University of Sport, China. LA - eng PT - Journal Article DEP - 20260618 PL - United States TA - J Atten Disord JT - Journal of attention disorders JID - 9615686 SB - IM OTO - NOTNLM OT - ADHD OT - CLGI OT - CRP OT - LTPA OT - inflammatory biomarkers EDAT- 2026/06/18 06:31 MHDA- 2026/06/18 06:31 CRDT- 2026/06/18 05:53 PHST- 2026/06/18 06:31 [medline] PHST- 2026/06/18 06:31 [pubmed] PHST- 2026/06/18 05:53 [entrez] AID - 10.1177/10870547261458103 [doi] PST - aheadofprint SO - J Atten Disord. 2026 Jun 18:10870547261458103. doi: 10.1177/10870547261458103. PMID- 42312170 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260618 LR - 20260813 IS - 2575-9108 (Electronic) IS - 2575-9108 (Linking) VI - 9 IP - 6 DP - 2026 Jun 12 TI - Age-Driven Physiologically Based Pharmacokinetic Modeling of Empagliflozin: Toward Precision Dosing in Youth. PG - 1412-1425 LID - 10.1021/acsptsci.5c00772 [doi] AB - Type 2 diabetes mellitus (T2DM) is a multifactorial disease that affects both adults and children. Treating T2DM in children poses a challenge because of the difficulties in conducting clinical trials in this special population. Empagliflozin (EMPA) is an antidiabetic drug belonging to the class of sodium-glucose cotransporter 2 (SGLT2) inhibitors and reversibly inhibits glucose reabsorption in the proximal tubules of the kidneys. This drug is a great candidate for treating T2DM in children due to its action on diabetes and other effects such as cardio- and nephroprotection. Despite its therapeutic advantages, the most appropriate dose for the treatment of T2DM in children is still unknown. In this context, new methodological approaches (NAMs) are necessary to overcome these obstacles. Physiologically based pharmacokinetic modeling (PBPK) emerges as a promising and regulatory-accepted approach that can be used to predict the most suitable dose for children. Therefore, the aim of this study was to construct the PBPK model for the oral administration of EMPA in children with healthy and obese weights. Following a literature search, pharmacokinetic and physicochemical parameters of the drug, along with physiological characteristics from selected studies for validation, were obtained for the model development. A PBPK model of EMPA was developed and verified in the adult population by comparing the simulated plasma exposure to the observed data. After validation for healthy adults, the model was scaled for children with healthy and obese weights according to the WHO metrics. The parameters that showed the most significant changes were the C (max) and AUC values. In children with healthy weights, C (max) was 1.93 and 1.39 times higher in the 10-12 year-old and 13-14 year-old groups, respectively, compared to adults receiving a 10 mg dose. Similarly, AUC increased by 1.81 and 1.48 times in the 10-12 year-old and 13-14 year-old groups, respectively, among healthy children. In obese children aged 10-12, C (max) and AUC were altered, showing increases of 1.77 and 1.81 times, respectively. The developed and validated empagliflozin PBPK model in adults provided a robust basis for extending research to pediatric populations. Simulations indicated the need for dose adjustments in pediatric patients, particularly for healthy children aged 10-14 and obese children aged 10-12. These adjustments are essential to minimizing adverse effects, ensuring the safe and effective use of empagliflozin in these age groups. CI - (c) 2026 The Authors. Published by American Chemical Society. FAU - Milhm, Gabriela Pereira AU - Milhm GP AUID- ORCID: 0009-0007-4517-5305 AD - Laboratory of Molecular Modeling & QSAR (ModMolQSAR), Faculty of Pharmacy, Federal University of Rio de Janeiro (UFRJ), Av. Carlos Chagas Filho, 373, bloco L subsolo, Cidade Universitaria, Rio de Janeiro, Brazil 21941-902. FAU - Moreira, Fernanda de Lima AU - Moreira FL AUID- ORCID: 0000-0001-7699-2665 AD - Laboratory of Pharmacometrics, Faculty of Pharmacy, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil 21941-902. FAU - Abrahim-Vieira, Barbara de Azevedo AU - Abrahim-Vieira BA AUID- ORCID: 0000-0001-6444-0169 AD - Laboratory of Molecular Modeling & QSAR (ModMolQSAR), Faculty of Pharmacy, Federal University of Rio de Janeiro (UFRJ), Av. Carlos Chagas Filho, 373, bloco L subsolo, Cidade Universitaria, Rio de Janeiro, Brazil 21941-902. LA - eng PT - Journal Article DEP - 20260529 PL - United States TA - ACS Pharmacol Transl Sci JT - ACS pharmacology & translational science JID - 101721411 PMC - PMC13270446 OTO - NOTNLM OT - PBPK (physiologically based pharmacokinetic model) OT - SGLT2 (sodium-glucose cotransporter 2) OT - T2DM OT - empagliflozin OT - pediatric OT - type 2 diabetes mellitus EDAT- 2026/06/18 06:32 MHDA- 2026/06/18 06:33 PMCR- 2026/05/29 CRDT- 2026/06/18 04:45 PHST- 2025/11/26 00:00 [received] PHST- 2026/05/06 00:00 [revised] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/18 06:33 [medline] PHST- 2026/06/18 06:32 [pubmed] PHST- 2026/06/18 04:45 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - 10.1021/acsptsci.5c00772 [doi] PST - epublish SO - ACS Pharmacol Transl Sci. 2026 May 29;9(6):1412-1425. doi: 10.1021/acsptsci.5c00772. eCollection 2026 Jun 12. PMID- 42311940 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260618 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Comparing food literacy by grade, sex, and food education exposure: construct validation of the food literacy BITE scale. PG - 1819437 LID - 10.3389/fnut.2026.1819437 [doi] LID - 1819437 AB - BACKGROUND: Food literacy provides a framework for understanding dietary behaviors in children and can inform priorities for and evaluate the effectiveness of food education interventions. The 4-dimension Food Literacy BITE scale is built on a child-centered food literacy framework and has been structurally validated in U.S. elementary schoolchildren. We conducted additional validity testing to assess the tool's generalizability, ability to differentiate mean food literacy by grade, sex, and food education exposure, and the association of food literacy score with food group consumption frequencies. MATERIALS AND METHODS: We administered the Food Literacy BITE scale and food frequency questionnaires to n = 690 4 (th) and 5 (th) -grade students from 10 elementary schools in Washington, DC, and Kentucky (52.5% 4 (th) grade, 55.8% 4+ years of food education, 52.8% girls). Stepwise series of multiple-group confirmatory factor analysis models assessed measurement invariance by grade, sex, and school-level food education history. We examined group differences in overall food literacy score and dimension scores using latent means and used multilevel modeling for the food education exposure analysis to account for clustering within schools. We used weighted regression with robust standard errors to investigate associations between food literacy scores and food group consumption frequencies, aggregated by school and grade (n = 20). RESULTS: Item interpretation was consistent across groups, with full scalar invariance established by grade and partial scalar invariance by sex and food education history (4+years vs. new/none). Girls scored higher than boys in the "confidence in everyday food skills" dimension (p = 0.03). Mean food literacy was higher in the group from schools offering 4+ years of experiential food education (p = 0.03), driven by higher scores in the "valuing shared food experiences" (p = 0.02) and "food systems and nutrition knowledge" (p = 0.04) dimensions. In the multilevel models, only the difference in "valuing shared food experiences" remained significant. CONCLUSION: Results support generalizable use of the Food Literacy BITE scale in the U.S. and areas with similar food practices and environments. The tool's ability to differentiate between food education exposure history suggests it may be useful in identifying best practices for food education interventions targeting late childhood. CI - Copyright (c) 2026 St. Pierre, Bingenheimer, van Dam and Sacheck. FAU - St Pierre, Christine AU - St Pierre C AD - Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States. FAU - Bingenheimer, Jeffrey B AU - Bingenheimer JB AD - Department of Prevention and Community Health, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States. FAU - van Dam, Rob M AU - van Dam RM AD - Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States. FAU - Sacheck, Jennifer M AU - Sacheck JM AD - Department of Exercise and Nutrition Sciences, Milken Institute School of Public Health, The George Washington University, Washington, DC, United States. AD - Department of Behavioral and Social Sciences, School of Public Health, Brown University, Providence, RI, United States. LA - eng PT - Journal Article DEP - 20260602 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13268878 OTO - NOTNLM OT - children OT - food education OT - food literacy OT - measurement properties OT - scale development COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/18 06:32 MHDA- 2026/06/18 06:33 PMCR- 2026/06/02 CRDT- 2026/06/18 04:42 PHST- 2026/02/27 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/06/18 06:33 [medline] PHST- 2026/06/18 06:32 [pubmed] PHST- 2026/06/18 04:42 [entrez] PHST- 2026/06/02 00:00 [pmc-release] AID - 10.3389/fnut.2026.1819437 [doi] PST - epublish SO - Front Nutr. 2026 Jun 2;13:1819437. doi: 10.3389/fnut.2026.1819437. eCollection 2026. PMID- 42310262 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260910 IS - 1573-6628 (Electronic) IS - 1092-7875 (Print) IS - 1092-7875 (Linking) VI - 30 IP - 8 DP - 2026 Aug TI - Baby-Feed Pilot Trial for Improving Diet and Weight Gain in Infants and Toddlers. PG - 1017-1027 LID - 10.1007/s10995-026-04282-z [doi] AB - OBJECTIVE: To pilot test the initial efficacy of the Baby-Feed website for improving infant diet quality (main outcome) and weight gain (exploratory outcome) compared to usual care. METHODS: This was a 3-month randomized clinical trial, in which two healthcare providers and 50 caregivers of healthy-term infants (4-12 months) in a community health center were recruited. Participants were randomized to usual care or access to the Baby-Feed website, which assesses infants' diets, provides automated results, and delivers feedback. Measures were assessed at baseline and at the end of the study: diet quality from a validated infant food frequency questionnaire (FFQ), self-reported weight/length to calculate rate of weight gain, and a validated self-efficacy questionnaire. Changes were compared using analysis of covariance or Chi-square/Fisher's Exact test. RESULTS: Baseline characteristics were similar between groups (n = 25 intervention; n = 25 control). Most caregivers were mothers (92%) and Hispanic (86%). Change in total diet quality scores was higher in the intervention (-2.95 +/- 6.53) vs. controls (-7.69 +/- 7.84; p = 0.031). Healthy weight gain was higher in the intervention group (n = 21, 95%) vs. controls (n = 14, 58%; p = 0.006). Changes in the self-efficacy score for promoting healthy foods were associated with changes in the fruit score (r = 0.46; p = 0.03), and changes in the self-efficacy score for limiting unhealthy foods were associated with changes in the juice score (r = 0.45; p = 0.04) only in the intervention group. CONCLUSIONS: Using Baby-Feed for 3 months improved diet quality and the rate of weight gain compared with controls in this small and short pilot trial. A larger, longer trial with a more diverse population is needed to confirm the results. TRIAL REGISTRY: https://clinicaltrials.gov/ : NCT05062824. CI - (c) 2026. The Author(s). FAU - Bolton, Jennifer AU - Bolton J AUID- ORCID: 0000-0002-8324-9113 AD - Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA. FAU - Wang, Wenjia AU - Wang W AUID- ORCID: 0000-0002-1967-0405 AD - Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA. AD - Vertically Integrated Projects, Knight Foundation School of Computing and Information Sciences, Florida International University, 11200 SW 8th Street, Miami, FL, 33199, USA. FAU - Coccia, Catherine AU - Coccia C AUID- ORCID: 0000-0002-8086-4479 AD - Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA. FAU - Narayanan, Vijaya AU - Narayanan V AUID- ORCID: 0009-0003-6685-1430 AD - Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA. FAU - Varella, Marcia AU - Varella M AUID- ORCID: 0000-0003-2626-8825 AD - Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street AHC1, Miami, FL, 33199, USA. FAU - Hannan, Jean AU - Hannan J AUID- ORCID: 0000-0003-3740-620X AD - Nicole Wertheim College of Nursing & Health Sciences, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA. FAU - Palacios, Cristina AU - Palacios C AUID- ORCID: 0000-0001-9437-0376 AD - Department of Dietetics and Nutrition, Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street AHC5, Miami, FL, 33199, USA. crpalaci@fiu.edu. AD - Department of Dietetics and Nutrition in the Robert Stempel College of Public Health & Social Work, Florida International University, 11200 SW 8th Street, AHC 5-313, Miami, 33199, FL, USA. crpalaci@fiu.edu. LA - eng SI - ClinicalTrials.gov/NCT05062824 GR - Children's Trust/Children's Trust/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20260618 PL - United States TA - Matern Child Health J JT - Maternal and child health journal JID - 9715672 SB - IM MH - Humans MH - Infant MH - *Weight Gain/physiology MH - Pilot Projects MH - Female MH - Male MH - *Diet/standards MH - *Infant Food MH - Surveys and Questionnaires MH - Infant Nutritional Physiological Phenomena MH - Internet PMC - PMC13503433 OTO - NOTNLM OT - Diet quality OT - Infant OT - Intervention OT - Website OT - Weight gain COIS- Declarations. Competing Interests: The authors have not disclosed any competing interests. Ethical Approval: Study procedures were approved by the IRB at Florida International University (Protocol Number: 20-0498). Data Sharing: Deidentified individual participant data (including the data dictionary) underlying the results reported in this study will be made available upon reasonable request to the corresponding author. EDAT- 2026/06/18 00:31 MHDA- 2026/08/25 05:34 PMCR- 2026/06/18 CRDT- 2026/06/17 23:26 PHST- 2025/03/08 00:00 [received] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/08/25 05:34 [medline] PHST- 2026/06/18 00:31 [pubmed] PHST- 2026/06/17 23:26 [entrez] PHST- 2026/06/18 00:00 [pmc-release] AID - 10.1007/s10995-026-04282-z [pii] AID - 4282 [pii] AID - 10.1007/s10995-026-04282-z [doi] PST - ppublish SO - Matern Child Health J. 2026 Aug;30(8):1017-1027. doi: 10.1007/s10995-026-04282-z. Epub 2026 Jun 18. PMID- 42310167 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260831 LR - 20260903 IS - 2731-4383 (Electronic) IS - 2731-4383 (Linking) VI - 6 IP - 1 DP - 2026 Jun 17 TI - A is for ___ : Narrative Medicine Framework for Mental Health Empowerment and Self-Authorship in Asian American Communities. LID - 10.1007/s44192-026-00490-9 [doi] LID - 164 AB - Mental health stigma and underutilization of psychiatric care remain significant challenges in Asian American, Native Hawaiian, and Pacific Islander (AANHPI) communities, driven by cultural norms of silence, the model minority myth, and structural barriers to care. Narrative medicine, a clinical approach that utilizes storytelling, reflective writing, and deep listening, offers a promising approach to address these challenges by centering identity, voice, and meaning making in mental health engagement, processes that are foundational to psychological healing. In this Perspective, we describe "A is for ___", a novel narrative medicine-based empowerment framework developed through A-Team Med, a community-based nonprofit organization. The framework is left intentionally blank to symbolize the tremendous diversity of the AANHPI experience and counter monolithic representations of Asian American identity. Applied in community settings, the framework invites participants to complete the prompt "A is for ___" by selecting a personally meaningful word beginning with the letter "A" that reflects the individual's AANHPI lived experience. This open-ended structure serves as an accessible entry point for self-authorship, critical reflection, and dialogue about the AANHPI experience and mental health topics traditionally underdiscussed within this community. We situate this intervention within theories of narrative identity, cultural psychiatry, and the social determinants of mental health. We describe the implementation of this framework in a community workshop with over 50 AANHPI adolescents across multiple underserved community centers in Los Angeles. Author observations of participant experiences suggest that the exercise facilitated emotional expression, reduced stigma surrounding mental health conversations, and fostered validation and a sense of belonging. We further discuss practical applications of this framework in clinical encounters, community psychoeducation, and youth programs, as well as its potential for digital and telehealth adaptation. By reframing mental health engagement through narrative agency rather than pathology, "A is for ___" offers a low-cost, scalable, and culturally responsive tool to support mental health destigmatization and empowerment in AANHPI and other marginalized communities. CI - (c) 2026. The Author(s). FAU - Yan, Matthew J AU - Yan MJ AUID- ORCID: 0000-0001-8301-1941 AD - A-Team Med, Los Angeles, CA, USA. matthewyan@mednet.ucla.edu. AD - , . matthewyan@mednet.ucla.edu. AD - David Geffen School of Medicine, University of California, Los Angeles (UCLA), 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA. matthewyan@mednet.ucla.edu. AD - Harvard Business School, Boston, MA, USA. matthewyan@mednet.ucla.edu. AD - Department of Stem Cell and Regenerative Biology, Harvard Graduate School of Arts and Sciences, Boston, MA, USA. matthewyan@mednet.ucla.edu. AD - Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston, MA, USA. matthewyan@mednet.ucla.edu. FAU - Lee, Hannah J AU - Lee HJ AD - A-Team Med, Los Angeles, CA, USA. AD - . AD - David Geffen School of Medicine, University of California, Los Angeles (UCLA), 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA. AD - Department of Health Policy and Management, UCLA Fielding School of Public Health, Los Angeles, CA, USA. FAU - Yan, Alexander J AU - Yan AJ AD - A-Team Med, Los Angeles, CA, USA. AD - . FAU - Yan, Victoria C AU - Yan VC AUID- ORCID: 0000-0003-0837-5184 AD - A-Team Med, Los Angeles, CA, USA. AD - . AD - University of Texas Southwestern Medical Center, Dallas, TX, USA. FAU - Bahk, Jason E AU - Bahk JE AD - A-Team Med, Los Angeles, CA, USA. AD - . AD - David Geffen School of Medicine, University of California, Los Angeles (UCLA), 10833 Le Conte Avenue, Los Angeles, CA, 90095, USA. FAU - Chen, Justin A AU - Chen JA AUID- ORCID: 0000-0002-1504-0094 AD - Department of Psychiatry, Weill Cornell Medicine/New York-Presbyterian, New York, NY, USA. FAU - Trinh, Nhi-Ha T AU - Trinh NT AUID- ORCID: 0000-0001-7812-9187 AD - Depression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA. FAU - Ng, Warren Y K AU - Ng WYK AD - Columbia University Irving Medical Center, New York-Presbyterian Hospital, New York, NY, USA. FAU - Lu, Francis G AU - Lu FG AUID- ORCID: 0000-0002-2032-2379 AD - Department of Psychiatry, University of California Davis, Davis, CA, USA. LA - eng PT - Journal Article PT - Review DEP - 20260617 PL - Switzerland TA - Discov Ment Health JT - Discover mental health JID - 9918350483906676 PMC - PMC13530052 OTO - NOTNLM OT - A is for ___ OT - A-Team Med OT - AANHPI OT - Asian American OT - Community health OT - Cultural psychiatry OT - Destigmatization OT - Empowerment OT - Identity OT - Mental health OT - Narrative medicine OT - Public health OT - Self-authorship OT - Storytelling COIS- Declarations. Ethics approval and consent to participate: This manuscript is a Perspective article and does not involve human subjects research. No identifiable participant data were collected or analyzed. As such, ethical approval was not required. Consent for publication: Not applicable. This manuscript does not include patient data, personal identifiers, or images requiring consent for publication. Competing interests: The authors declare no competing interests. EDAT- 2026/06/18 00:31 MHDA- 2026/06/18 00:32 PMCR- 2026/06/17 CRDT- 2026/06/17 23:22 PHST- 2025/10/21 00:00 [received] PHST- 2026/05/14 00:00 [accepted] PHST- 2026/06/18 00:32 [medline] PHST- 2026/06/18 00:31 [pubmed] PHST- 2026/06/17 23:22 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - 10.1007/s44192-026-00490-9 [pii] AID - 490 [pii] AID - 10.1007/s44192-026-00490-9 [doi] PST - epublish SO - Discov Ment Health. 2026 Jun 17;6(1):164. doi: 10.1007/s44192-026-00490-9. PMID- 42309663 OWN - NLM STAT- MEDLINE DCOM- 20260617 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 6 DP - 2026 Jun 17 TI - Measuring multisector nutrition and health intervention coverage using composite coverage analysis methods: a scoping review and methodological guidance. PG - e111298 LID - 10.1136/bmjopen-2025-111298 [doi] LID - e111298 AB - OBJECTIVES: Composite indices provide an opportunity to measure the reach of multisector strategies as countries progress towards Sustainable Development Goals and the achievement of nutrition, health and other sectoral targets. Composite measures allow for the measurement of nutrition and health intervention coverage across sectors and can be used to benchmark progress, track nutrition goals and assess inequities of multisector nutrition interventions. Of the many composite indices in use to measure health and nutrition intervention coverage and population status as a means of assessing progress in achieving health and nutrition targets, few have been previously documented in the nutrition and health literature, nor have these indicators been described in detail. This scoping review aimed to identify composite coverage indices that capture nutrition and health intervention coverage or status, summarise their estimation methodologies and validation approaches and evaluate their strengths and weaknesses. DESIGN: Scoping review conducted in accordance with the Joanna Briggs Institute Reviewer Manual following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) verification list. DATA SOURCES: PubMed, EMBASE, Scopus, Google Scholar and Global Health registries were searched from 1980 to 3 March 2026. ELIGIBILITY CRITERIA: We included studies of any design that described, used or developed a composite measurement of health or nutrition intervention coverage or status. DATA EXTRACTION AND SYNTHESIS: One reviewer screened the titles and abstracts and full text using Covidence and abstracted data from each article using Microsoft Excel using standardised methods. RESULTS: We retrieved and screened a total of 7120 records of which 154 articles were included. We identified a total of 56 unique indices (25 universal healthcare coverage; 14 reproductive, maternal, newborn, child health (RMNCH) coverage; 10 nutritional status, food security or nutrition intervention coverage; 6 health service coverage and 1 combined universal healthcare, health risk factors and nutrition coverage measure). We identified three major formula construction methodologies: normative (n=34), statistical (n=13) and participatory (n=10). Together, the indices employed six different aggregation methods: weighted linear mean (n=28), geometric mean (n=13), linear mean (n=9), random-effects meta-analysis (n=6), summation (n=2) and weighted geometric mean (n=1). More than one third of the indices identified have not been validated in the literature (n=21). CONCLUSIONS: Our review identified a significant gap in composite nutrition intervention coverage index availability, methodological frameworks for index design and index validation. There is a need for additional resources for guiding policy and programme actors to develop validated, fit for purpose composite nutrition-specific and nutrition-sensitive coverage indices. We propose that a framework be developed for stakeholders to guide composite index construction for multisectoral nutrition intervention coverage measurement. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Morrison, Taylor AU - Morrison T AUID- ORCID: 0009-0006-5346-5946 AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA tmorri45@alumni.jh.edu. FAU - Akseer, Nadia AU - Akseer N AUID- ORCID: 0000-0002-3802-7298 AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Heidkamp, Rebecca AU - Heidkamp R AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Maiga, Abdoulaye AU - Maiga A AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Tasic, Hana AU - Tasic H AUID- ORCID: 0009-0006-0589-3612 AD - Modern Scientist Global, St Catharines, Ontario, Canada. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260617 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Nutritional Status PMC - PMC13288883 OTO - NOTNLM OT - Health Equity OT - Health Services Accessibility OT - Health policy COIS- Competing interests: None declared. EDAT- 2026/06/18 00:32 MHDA- 2026/06/18 00:33 PMCR- 2026/06/17 CRDT- 2026/06/17 21:12 PHST- 2026/06/18 00:33 [medline] PHST- 2026/06/18 00:32 [pubmed] PHST- 2026/06/17 21:12 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - bmjopen-2025-111298 [pii] AID - 10.1136/bmjopen-2025-111298 [doi] PST - epublish SO - BMJ Open. 2026 Jun 17;16(6):e111298. doi: 10.1136/bmjopen-2025-111298. PMID- 42308182 OWN - NLM STAT- MEDLINE DCOM- 20260617 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - A risk assessment indicator system for common diseases in children and adolescents. PG - e0351870 LID - 10.1371/journal.pone.0351870 [doi] LID - e0351870 AB - BACKGROUND: Adolescence is a critical stage for healthy development. Currently, common diseases such as myopia, obesity, dental caries, and spinal curvature abnormalities are highly prevalent among children and adolescents, with an obvious trend of younger onset. These diseases are caused by the complex interaction of multi-dimensional factors. However, existing interventions are mostly limited to individual diseases, lacking systematic prevention and control tools. Therefore, there is an urgent need to construct a scientific evaluation index system for health-influencing factors. OBJECTIVE: Targeting the four key common diseases emphasized in China's national health policies - myopia, obesity, dental caries, and spinal curvature abnormalities - among children and adolescents aged 7-19 years, this study constructed a multi-dimensional risk assessment indicator system to support evidence-based prevention and policy-making for this population. METHODS: Guided by the National Program of Action for Children's Development in China (2021-2030) and the "Healthy China 2030" Planning Outline, a three-level indicator framework was initially formulated through literature research and expert meetings. The Delphi expert consultation method was adopted for two rounds of screening and optimization of indicators. Experts scored each indicator on a scale of 1-5 in terms of importance, feasibility, and sensitivity, with indicators excluded if their mean score was < 3.5 and coefficient of variation >0.3. RESULTS: The effective return rate of the two-round Delphi is 100.0%, the mean expert familiarity coefficient (Cs) was 0.83, and the mean judgment coefficient (Ca) was 0.93, and the expert authoritative coefficient (Cr) value is 0.88. In the second round of consultation, the importance coordination coefficient is 0.284, the feasibility coordination coefficient is 0.185, and the sensitivity coordination coefficient is 0.314, all of which are statistically significant (P < 0.001). This indicator system consists of a total of 55 three-level indicators. CONCLUSION: Validated through two rounds of expert deliberation, the indicator system demonstrates sound scientific rigor. The preliminary development of a risk assessment indicator system for common diseases in children and adolescents can be used for the measurement of the level of factors affecting the health of common diseases in children and adolescents after its reliability and validity are verified in practical applications. CI - Copyright: (c) 2026 Shao et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Shao, Yun AU - Shao Y AD - School of Public Health, Fudan University, Shanghai, China. AD - Shanghai Putuo District Center for Disease Control and Prevention, Shanghai, China. FAU - Hu, Bohan AU - Hu B AD - School of Public Health, Fudan University, Shanghai, China. AD - Shanghai Putuo District Center for Disease Control and Prevention, Shanghai, China. FAU - Lu, Yuting AU - Lu Y AD - School of Public Health, Fudan University, Shanghai, China. AD - Shanghai Putuo District Center for Disease Control and Prevention, Shanghai, China. FAU - Yu, Shuo AU - Yu S AD - NHC Key Laboratory of Health Technology Assessment (Fudan University), Shanghai, China. FAU - Liang, Ji AU - Liang J AUID- ORCID: 0000-0002-6844-5036 AD - School of Public Health, Fudan University, Shanghai, China. AD - Shanghai Putuo District Center for Disease Control and Prevention, Shanghai, China. LA - eng PT - Journal Article DEP - 20260617 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Child MH - Adolescent MH - Risk Assessment/methods MH - China/epidemiology MH - Female MH - Male MH - *Dental Caries/epidemiology/prevention & control MH - *Myopia/epidemiology/prevention & control MH - *Obesity/epidemiology/prevention & control MH - Young Adult PMC - PMC13274816 COIS- The authors have declared that no competing interests exist. EDAT- 2026/06/17 18:35 MHDA- 2026/06/17 18:36 PMCR- 2026/06/17 CRDT- 2026/06/17 13:33 PHST- 2025/11/08 00:00 [received] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/06/17 18:36 [medline] PHST- 2026/06/17 18:35 [pubmed] PHST- 2026/06/17 13:33 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - PONE-D-25-58634 [pii] AID - 10.1371/journal.pone.0351870 [doi] PST - epublish SO - PLoS One. 2026 Jun 17;21(6):e0351870. doi: 10.1371/journal.pone.0351870. eCollection 2026. PMID- 42307362 OWN - NLM STAT- MEDLINE DCOM- 20260617 LR - 20260813 IS - 1474-7049 (Electronic) IS - 1474-7049 (Linking) VI - 24 IP - 2 DP - 2026 Apr-Jun TI - Buttocks or Breasts? Identifying Latent Subgroups in Male Preferences for Female Bodily Features. PG - 14747049261452897 LID - 10.1177/14747049261452897 [doi] LID - 14747049261452897 AB - Among the various physical traits that serve as secondary sexual characteristics, breasts and buttocks are visually conspicuous cues used in male mate evaluation because they signal youth, fertility, developmental stability, and nutritional status. Although these features have been extensively studied, less is known about the extent to which men differ in the relative importance they place on each trait. Latent Profile Analysis (LPA) identified distinct subgroups of Norwegian men (N = 395) based on how much importance they placed on breasts and buttocks in their evaluations of romantic partners. A four-class solution emerged, comprising Highly Body-Oriented (53%), Moderately Body-Oriented (20%), Buttocks-Oriented (18%), and Body-Unoriented (9%) subgroups. Predictors such as egalitarianism, materialism, and preferences for sexiness were, as expected, significantly associated with class membership, providing support for the validity of the typology. Notably, a consistent buttocks-oriented class emerged across all LPA solutions, whereas no distinct breasts-oriented group was found, as ratings of breasts persistently co-occurred with high ratings of buttocks, suggesting that breasts do not function as a primary preference in isolation. These findings reveal that buttocks may occupy a more central and stable role than breasts in male mate preferences, offering novel insights into the structure of physical attraction and heterogeneity in the male mating mind. FAU - Mehmetoglu, Mehmet AU - Mehmetoglu M AUID- ORCID: 0000-0002-6092-8551 AD - Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway. RINGGOLD: 8018 LA - eng PT - Journal Article DEP - 20260617 PL - England TA - Evol Psychol JT - Evolutionary psychology : an international journal of evolutionary approaches to psychology and behavior JID - 101219668 SB - IM MH - Humans MH - Male MH - Adult MH - *Breast MH - Young Adult MH - Buttocks MH - *Sexual Partners/psychology MH - *Choice Behavior/physiology MH - Norway MH - Female PMC - PMC13276209 OTO - NOTNLM OT - LPA OT - attractiveness OT - bodily OT - breasts OT - buttocks OT - male preference OT - physical COIS- Declaration of Conflicting InterestsThe author declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/06/17 13:28 MHDA- 2026/06/17 13:29 PMCR- 2026/06/17 CRDT- 2026/06/17 09:23 PHST- 2026/06/17 13:29 [medline] PHST- 2026/06/17 13:28 [pubmed] PHST- 2026/06/17 09:23 [entrez] PHST- 2026/06/17 00:00 [pmc-release] AID - 10.1177_14747049261452897 [pii] AID - 10.1177/14747049261452897 [doi] PST - ppublish SO - Evol Psychol. 2026 Apr-Jun;24(2):14747049261452897. doi: 10.1177/14747049261452897. Epub 2026 Jun 17. PMID- 42307272 OWN - NLM STAT- MEDLINE DCOM- 20260617 LR - 20260813 IS - 1807-3107 (Electronic) IS - 1806-8324 (Print) IS - 1806-8324 (Linking) VI - 40 DP - 2026 TI - Evaluation of the impacted upper canine and maxillary sinus dimensions using cone beam computed tomography. PG - e031 LID - S1806-83242026000108601 [pii] LID - 10.1590/1807-3107bor-2026.vol40.031 [doi] LID - e031 AB - This study aimed use cone beam computed tomography (CBCT) to compare the maxillary sinus volume and transverse dimensions between sides with and without palatally impacted maxillary canines. The CBCT records of 47 patients with unilateral palatally impacted canines (18 males, 29 females; mean age: 22.19 +/- 7.71 years) were included. The maxillary sinus volume was measured using semiautomatic segmentation, and transversal maxillary dimensions were assessed in the posterior region. Deviation of the nasal septum and alveolar pneumatization were also evaluated. Statistical analyses were performed using SPSS 25.0 with a significance level set at p < 0.05. As compared with the nonimpacted side, the maxillary and molar basal widths were significantly smaller and the septum deviation angle was greater on the impacted side (p < 0.05). A one-unit increase in the septal deviation angle increased the probability of impaction by 1.177 times. A negative correlation was detected between the maxillary sinus intensity and zygomatic width, molar basal width, and molar alveolar width (r = 0.431, 0.316, and 0.351, respectively). The incidence of pathological sinus findings did not differ significantly between sides (38.3% vs. 51.06%). Similarly, the rates of alveolar pneumatization were comparable (51.06% vs. 48.94%). The mean sinus volumes were 13,147.96 voxels on the impacted side and 13,194.38 voxels on the nonimpacted side, with no significant difference (p > 0.05). In conclusion, although palatally impacted maxillary canines are associated with narrower posterior maxillary transverse dimensions and increased septal deviation, they do not have a considerable effect on the maxillary sinus volume. These findings provide clinically relevant information for orthodontic diagnosis and surgical planning. FAU - Kurnaz, Merve AU - Kurnaz M AUID- ORCID: 0000-0003-2945-755X AD - Istanbul Kent University, School of Dentistry, Department of Orthodontics, Istanbul, Turkey. FAU - Kaygisiz, Emine AU - Kaygisiz E AUID- ORCID: 0000-0003-2087-7048 AD - Private Practice, Bursa, Turkey. FAU - Akay, Gulsun AU - Akay G AUID- ORCID: 0000-0002-1767-1383 AD - Gazi University, School of Dentistry, Department of Dentomaxillofacial Radiology, Ankara, Turkey. FAU - Gungor, Kahraman AU - Gungor K AUID- ORCID: 0000-0001-6336-4424 AD - Gazi University, School of Dentistry, Department of Dentomaxillofacial Radiology, Ankara, Turkey. FAU - Tortop, Tuba AU - Tortop T AUID- ORCID: 0000-0001-6153-2412 AD - Gazi University, School of Dentistry, Department of Orthodontics, Ankara, Turkey. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20260612 PL - Brazil TA - Braz Oral Res JT - Brazilian oral research JID - 101307187 SB - IM MH - Humans MH - *Cone-Beam Computed Tomography/methods MH - Female MH - *Maxillary Sinus/diagnostic imaging/pathology MH - *Tooth, Impacted/diagnostic imaging/pathology MH - Reference Values MH - Male MH - *Cuspid/diagnostic imaging MH - Young Adult MH - Adult MH - Reproducibility of Results MH - Adolescent MH - Statistics, Nonparametric MH - Maxilla/diagnostic imaging MH - Organ Size PMC - PMC13263044 COIS- Declaration of interest: The authors certify that they have no commercial or associative interest that represents a conflict of interest in connection with the manuscript. EDAT- 2026/06/17 13:28 MHDA- 2026/06/17 13:29 PMCR- 2026/06/12 CRDT- 2026/06/17 09:22 PHST- 2025/08/28 00:00 [received] PHST- 2026/01/08 00:00 [accepted] PHST- 2026/06/17 13:29 [medline] PHST- 2026/06/17 13:28 [pubmed] PHST- 2026/06/17 09:22 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - S1806-83242026000108601 [pii] AID - 10.1590/1807-3107bor-2026.vol40.031 [doi] PST - epublish SO - Braz Oral Res. 2026 Jun 12;40:e031. doi: 10.1590/1807-3107bor-2026.vol40.031. eCollection 2026. PMID- 42307182 OWN - NLM STAT- MEDLINE DCOM- 20260617 LR - 20260813 IS - 1552-5783 (Electronic) IS - 0146-0404 (Print) IS - 0146-0404 (Linking) VI - 67 IP - 6 DP - 2026 Jun 1 TI - Early Prediction Model for Retinopathy of Prematurity Using Placental and Neonatal Risk Factors. PG - 35 LID - 10.1167/iovs.67.6.35 [doi] LID - 35 AB - PURPOSE: Existing prediction models for retinopathy of prematurity (ROP) primarily focus on screening reduction which occur 5 to 7 weeks after birth. We hypothesized that high-risk neonates could be identified much earlier if placental and early postnatal risk factors are incorporated, so that this high risk can be considered during neonatal treatment well before ROP screening begins. METHODS: We included 591 neonates born 1.0). Induction remission, TRM, complications, and treatment toxicity were compared across the three groups. Multivariate logistic regression analysis was performed to identify the associations between nutritional indicator changes and induction treatment outcomes. Receiver operating characteristic (ROC) curves were evaluated the predictive performance of weight Z-score decline for treatment toxicities and remission-phase mortality. RESULTS: Clinical data of a total of 62 pediatric patients (34 males, 28 females; mean age 7.3 +/- 3.6 years) were analyzed. Longitudinal monitoring revealed a consistent decline - then - recovery trend for weight Z-score, BMI Z-score, and serum albumin: all indicators decreased continuously from T0 to T2, followed by gradual recovery from T2 to T3. Weight Z-score and BMI Z-score reached their nadirs at T2, while serum albumin bottomed out at T1. Patients with severe weight Z-score decline showed significantly lower remission rates (56.3% vs. 88.5% in mild and 75.0% in moderate groups) and higher TRM (18.8%) and complication rates (87.5%). They also experienced more frequent gastrointestinal, hepatic, and infectious toxicities, and higher remission-phase mortality (12.5% vs. 0.0 and 5.0%). Multivariate analysis identified weight Z-score decline > 1.0 (OR = 4.826, 95%CI: 2.673-8.725) and serum albumin decline > 10 g/L (OR = 3.715, 95%CI: 2.012-6.857) as independent risk factors for poor outcomes. ROC analysis confirmed strong predictive value of weight Z-score decline for gastrointestinal toxicity (AUC = 0.823), hepatic toxicity (AUC = 0.812), infectious toxicity (AUC = 0.854), and remission-phase mortality (AUC = 0.881). CONCLUSION: The nutritional status of pediatric patients with newly diagnosed AML follows a distinct decline-then-recovery longitudinal pattern during induction chemotherapy. Greater decline and slower recovery are significantly associated with worse treatment outcomes. Weight Z-score decline serves as a robust predictor of subsequent toxicities and mortality, supporting its use alongside traditional static assessments. These findings provide an evidence-based rationale for initiating nutritional support by the time chemotherapy ends. CI - Copyright (c) 2026 Liu, Yan and Li. FAU - Liu, Chun-Lei AU - Liu CL AD - Department of Information Technology, Children's Hospital Affiliated to Shandong University (Jinan Children's Hospital), Jinan, Shandong, China. FAU - Yan, Fan-Ling AU - Yan FL AD - Department of Pediatrics, Children's Hospital Affiliated to Shandong University (Jinan Children's Hospital), Jinan, Shandong, China. FAU - Li, Xiao-Ling AU - Li XL AD - Department of Pediatrics, Children's Hospital Affiliated to Shandong University (Jinan Children's Hospital), Jinan, Shandong, China. LA - eng PT - Journal Article DEP - 20260601 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC13265345 OTO - NOTNLM OT - induction chemotherapy OT - longitudinal changes OT - nutritional status OT - pediatric acute myeloid leukemia OT - serum albumin OT - treatment outcomes OT - treatment toxicity OT - weight Z-score COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/17 06:31 MHDA- 2026/06/17 06:32 PMCR- 2026/06/01 CRDT- 2026/06/17 05:16 PHST- 2026/03/26 00:00 [received] PHST- 2026/05/12 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/17 06:32 [medline] PHST- 2026/06/17 06:31 [pubmed] PHST- 2026/06/17 05:16 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - 10.3389/fmed.2026.1839597 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Jun 1;13:1839597. doi: 10.3389/fmed.2026.1839597. eCollection 2026. PMID- 42304432 OWN - NLM STAT- MEDLINE DCOM- 20260618 LR - 20260813 IS - 1868-7083 (Electronic) IS - 1868-7075 (Print) IS - 1868-7075 (Linking) VI - 18 IP - 1 DP - 2026 Jun 16 TI - Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study. LID - 10.1186/s13148-026-02177-y [doi] LID - 118 AB - BACKGROUND: Blood-based DNA methylation has been linked to obesity and metabolic health, yet its relationship to adipose tissue function remains incompletely understood. This study aimed to investigate the epigenetic regulation of EIF5A (Eukaryotic translation initiation factor 5A-1) and TGIF1 (TGFB Induced Factor Homeobox 1) across blood and adipose tissue in obesity. METHODS: Candidate genes were identified using a multi-step gene selection approach integrating transcriptomic and epigenomic data from blood and adipose tissue samples obtained from children and adults across four diverse population- and disease-focused cohorts. Genes were prioritized based on differential DNA methylation and gene expression in obesity. Targeted bisulfite sequencing of EIF5A and TGIF1 was conducted in blood samples from adults across BMI-defined groups and from children prior to the development of obesity, to validate candidate loci and to examine associations with metabolic and adipocyte-related phenotypes. RESULTS: In adults from the Leipzig Obesity BioBank, blood DNA methylation (N = 150) of both EIF5A and TGIF1 was significantly increased in individuals with obesity. EIF5A mRNA expression (N = 1554) was significantly higher in omental-visceral adipose tissue compared with subcutaneous adipose tissue. Blood DNA methylation of EIF5A was associated with body mass index (BMI), glycated hemoglobin (HbA1c), and leukocyte counts, particularly among individuals with type 2 diabetes mellitus. In children, blood DNA methylation (N = 75) of EIF5A was associated with longitudinal HbA1c trajectories. For TGIF1, DNA methylation levels were increased in subcutaneous adipose tissue (N = 219) of children with obesity and correlated with fasting serum insulin concentrations. Across cohorts, TGIF1 regulation in both blood and adipose tissue showed consistent associations with adipocyte size. Notably, blood DNA methylation of TGIF1 in childhood was associated with body fat mass and HbA1c at later follow-up despite normal weight at baseline. CONCLUSION: EIF5A and TGIF1 DNA methylation represent cross-tissue epigenetic signatures linking blood-based DNA methylation to adipose tissue dysfunction, adipocyte hypertrophy, and early metabolic risk. These findings support the potential of blood DNA methylation markers to reflect adipose tissue health and metabolic outcomes across the lifespan. CI - (c) 2026. The Author(s). FAU - Ruf, Sophie AU - Ruf S AD - Medical Department III - Endocrinology, Nephrology and Rheumatology, Leipzig University, Liebigstrasse 19, 04103, Leipzig, Germany. FAU - Hoffmann, Anne AU - Hoffmann A AD - Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at Leipzig University and University of Leipzig Medical Center, Philipp-Rosenthal Str. 27, 04103, Leipzig, Germany. FAU - Muller, Luise AU - Muller L AD - Medical Department III - Endocrinology, Nephrology and Rheumatology, Leipzig University, Liebigstrasse 19, 04103, Leipzig, Germany. FAU - Landgraf, Kathrin AU - Landgraf K AD - Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at Leipzig University and University of Leipzig Medical Center, Philipp-Rosenthal Str. 27, 04103, Leipzig, Germany. AD - Center for Pediatric Research, Leipzig University, Medical Faculty, University Hospital for Children and Adolescents, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig, Germany. FAU - Vogel, Mandy AU - Vogel M AD - Center for Pediatric Research, Leipzig University, Medical Faculty, University Hospital for Children and Adolescents, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig, Germany. AD - LIFE - Leipzig Research Centre for Civilization Diseases, Leipzig University, Leipzig, Germany. FAU - Jorsboe, Emil AU - Jorsboe E AD - Nuffield Department of Population Health, University of Oxford, Oxford, UK. AD - Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK. AD - Faculty of Health and Medical Sciences, Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. AD - Center for Liver Research, Department of Gastroenterology and Hepatology, Odense University Hospital, Odense, Denmark. FAU - Kubitz, Phil AU - Kubitz P AD - Else Kroner-Fresenius-Center for Nutritional Medicine, Chair of Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising-Weihenstephan, Germany. AD - Institute for Nutritional Medicine, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Dietrich, Arne AU - Dietrich A AD - Medical Department of Visceral, Transplantation, Thoracic and Vascular Surgery, University of Leipzig, Leipzig, Germany. FAU - Ghosh, Adhideb AU - Ghosh A AD - Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland. FAU - Noe, Falko AU - Noe F AD - Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland. FAU - Wolfrum, Christian AU - Wolfrum C AD - Institute of Food, Nutrition and Health, ETH Zurich, Schwerzenbach, Switzerland. FAU - Claussnitzer, Melina AU - Claussnitzer M AD - Medical and Population Genetics Program & Broad Diabetes Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA. AD - Novo Nordisk Foundation Center for Genomic Mechanisms of Disease, Broad Institute of MIT and Harvard, Cambridge, MA, USA. AD - Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA, USA. FAU - Hauner, Hans AU - Hauner H AD - Else Kroner-Fresenius-Center for Nutritional Medicine, Chair of Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising-Weihenstephan, Germany. AD - Institute for Nutritional Medicine, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Stumvoll, Michael AU - Stumvoll M AD - Medical Department III - Endocrinology, Nephrology and Rheumatology, Leipzig University, Liebigstrasse 19, 04103, Leipzig, Germany. AD - Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at Leipzig University and University of Leipzig Medical Center, Philipp-Rosenthal Str. 27, 04103, Leipzig, Germany. AD - LeiCeM - Leipzig Center of Metabolism, Leipzig University, Leipzig, Germany. FAU - Baber, Ronny AU - Baber R AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig, Germany. AD - LIFE - Leipzig Research Centre for Civilization Diseases, Leipzig University, Leipzig, Germany. AD - Institute of Laboratory Medicine, Clinical Chemistry, and Molecular Diagnostics, Leipzig University, Leipzig, Germany. FAU - Bluher, Matthias AU - Bluher M AD - Medical Department III - Endocrinology, Nephrology and Rheumatology, Leipzig University, Liebigstrasse 19, 04103, Leipzig, Germany. AD - Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at Leipzig University and University of Leipzig Medical Center, Philipp-Rosenthal Str. 27, 04103, Leipzig, Germany. AD - LeiCeM - Leipzig Center of Metabolism, Leipzig University, Leipzig, Germany. AD - German Center for Diabetes Research (DZD), Neuherberg, Germany. FAU - Korner, Antje AU - Korner A AD - Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at Leipzig University and University of Leipzig Medical Center, Philipp-Rosenthal Str. 27, 04103, Leipzig, Germany. AD - Center for Pediatric Research, Leipzig University, Medical Faculty, University Hospital for Children and Adolescents, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden, Leipzig, Germany. AD - LIFE - Leipzig Research Centre for Civilization Diseases, Leipzig University, Leipzig, Germany. AD - LeiCeM - Leipzig Center of Metabolism, Leipzig University, Leipzig, Germany. FAU - Kovacs, Peter AU - Kovacs P AD - Medical Department III - Endocrinology, Nephrology and Rheumatology, Leipzig University, Liebigstrasse 19, 04103, Leipzig, Germany. peter.kovacs@medizin.uni-leipzig.de. AD - German Center for Diabetes Research (DZD), Neuherberg, Germany. peter.kovacs@medizin.uni-leipzig.de. FAU - Keller, Maria AU - Keller M AD - Medical Department III - Endocrinology, Nephrology and Rheumatology, Leipzig University, Liebigstrasse 19, 04103, Leipzig, Germany. maria.keller@helmholtz-munich.de. AD - Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG), Helmholtz Munich at Leipzig University and University of Leipzig Medical Center, Philipp-Rosenthal Str. 27, 04103, Leipzig, Germany. maria.keller@helmholtz-munich.de. AD - German Center for Diabetes Research (DZD), Neuherberg, Germany. maria.keller@helmholtz-munich.de. LA - eng PT - Journal Article DEP - 20260616 PL - Germany TA - Clin Epigenetics JT - Clinical epigenetics JID - 101516977 RN - 0 (Homeodomain Proteins) RN - 0 (RNA-Binding Proteins) RN - 0 (Eukaryotic Translation Initiation Factor 5A) RN - 0 (Peptide Initiation Factors) RN - 0 (Repressor Proteins) RN - 0 (TGIF1 protein, human) RN - 0 (Glycated Hemoglobin) SB - IM MH - Humans MH - *DNA Methylation MH - Female MH - Male MH - *Homeodomain Proteins/genetics/blood MH - *Obesity/genetics/blood/metabolism MH - *RNA-Binding Proteins/genetics/blood MH - Eukaryotic Translation Initiation Factor 5A MH - *Peptide Initiation Factors/genetics/blood MH - *Repressor Proteins/genetics/blood MH - *Adipose Tissue/metabolism MH - Child MH - Cohort Studies MH - Adult MH - Epigenesis, Genetic MH - Body Mass Index MH - Middle Aged MH - Glycated Hemoglobin PMC - PMC13274240 OTO - NOTNLM OT - Adipose tissue OT - Blood OT - Childhood OT - DNA methylation OT - Epigenetics OT - Metabolism OT - Obesity OT - mRNA expression COIS- Declarations. Ethics approval and consent to participate: All participants or their parents gave written informed consent to participate in the studies. Procedures were approved by the University of Leipzig's ethics committee (LIFE Adult: Reg. No. 263-2009-14122009; LOBB: Reg. No. 159-12-21052012, 017ek-2012; LIFE Child: Reg. No. 264-10-19042010; Leipzig AT Childhood cohort: Reg. No. 265-08, 265-08-ff, NCT02208141) and conducted according to the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: MB received honoraria as a consultant and speaker from Amgen, AstraZeneca, Bayer, Boehringer Ingelheim, Lilly, Novo Nordisk, Novartis, and Sanofi. All other authors declare no conflicts of interest. The funders had no role in the design of the study, the collection, analyses, or interpretation of data, in the decision to publish the results and the writing of the manuscript. EDAT- 2026/06/17 06:31 MHDA- 2026/06/18 06:32 PMCR- 2026/06/16 CRDT- 2026/06/17 00:13 PHST- 2026/02/27 00:00 [received] PHST- 2026/05/30 00:00 [accepted] PHST- 2026/06/18 06:32 [medline] PHST- 2026/06/17 06:31 [pubmed] PHST- 2026/06/17 00:13 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 10.1186/s13148-026-02177-y [pii] AID - 2177 [pii] AID - 10.1186/s13148-026-02177-y [doi] PST - epublish SO - Clin Epigenetics. 2026 Jun 16;18(1):118. doi: 10.1186/s13148-026-02177-y. PMID- 42304284 OWN - NLM STAT- MEDLINE DCOM- 20260617 LR - 20260813 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jun 16 TI - Timing of primary maxillary tooth eruption in preterm compared to term infants: a retrospective longitudinal cohort study. LID - 10.1186/s12903-026-08851-0 [doi] LID - 1064 AB - BACKGROUND: Reported eruption times of primary teeth in term and preterm infants are largely based on detection of visible tooth structure at the gingival level by parents, paediatricians, or dentists. Furthermore, there is a lack of quantitative data on primary tooth eruption velocity in the literature. This study aimed to compare eruption timing, eruption velocity, and maximum crown length by modelling longitudinal crown eruption trajectories in term and preterm infants. METHODS: This retrospective longitudinal cohort study included 100 infants (51 preterm, 49 full-term) who were followed from the first weeks after birth with quarterly assessments over four years. A total of 626 serial maxillary plaster casts were obtained as part of a prospective clinical trial registered at clinicaltrials.gov (NCT00408746). The crown length of 1,885 primary teeth (central and lateral incisors, canines, first molars) was measured by one investigator on digitised casts using Blender software. Intrarater reliability was evaluated using intraclass correlation coefficients (ICC). Timing and velocity of eruption were estimated using a non-linear asymptotic growth model. RESULTS: Measurement reliability was excellent (ICC = 0.996). Comparing chronological age revealed that preterm infants had a mean eruption delay of 2.7 months compared to full-term infants, with a significant delay observed for canines (4.5 months). However, when corrected age (chronological age minus days born before 37 gestational weeks) was used, a mean delay of only 1.4 months with no significant differences was found. Model-derived eruption preceded commonly reported clinical eruption ages by 6.2 months in preterm and 7.7 months in full-term infants. The model-estimated maximum crown lengths were slightly smaller in preterm infants, though these differences were not statistically significant. Eruption velocity followed a non-linear pattern, with preterm infants showing a tendency towards higher eruption rates, suggesting catch-up growth. CONCLUSIONS: Based on our model, eruption timings reported in the literature likely correspond to clinical observations made when primary teeth have attained about half of their final crown height. Consequently, crown exposure through gingiva appears to occur on average about six months prior to clinically visible eruption. Although preterm infants show a delay in tooth eruption when assessed by their chronological age, this difference resolves after correction for prematurity. CI - (c) 2026. The Author(s). FAU - Hohoff, Ariane AU - Hohoff A AD - Department of Orthodontics, University of Munster, Albert-Schweitzer-Campus 1, Gebaude W 30, Munster, 48149, Germany. FAU - Bosse, Linda AU - Bosse L AD - Department of Orthodontics, University of Munster, Albert-Schweitzer-Campus 1, Gebaude W 30, Munster, 48149, Germany. FAU - Stamm, Thomas AU - Stamm T AD - Department of Orthodontics, University of Munster, Albert-Schweitzer-Campus 1, Gebaude W 30, Munster, 48149, Germany. FAU - Schmid, Jonas Q AU - Schmid JQ AD - Department of Orthodontics, University of Munster, Albert-Schweitzer-Campus 1, Gebaude W 30, Munster, 48149, Germany. FAU - Kanemeier, Moritz AU - Kanemeier M AD - Department of Orthodontics, University of Munster, Albert-Schweitzer-Campus 1, Gebaude W 30, Munster, 48149, Germany. kanemeier@uni-muenster.de. LA - eng SI - ClinicalTrials.gov/NCT00408746 PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20260616 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Female MH - Humans MH - Infant MH - Infant, Newborn MH - Male MH - *Infant, Premature/physiology MH - Longitudinal Studies MH - Maxilla MH - Odontometry/methods MH - Retrospective Studies MH - Time Factors MH - Tooth Crown/anatomy & histology/growth & development MH - *Tooth Eruption/physiology MH - *Tooth, Deciduous/growth & development PMC - PMC13273975 OTO - NOTNLM OT - Preterm OT - Term OT - Tooth eruption COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of the Medical Association Westphalia-Lippe (vdl/Ro, 13.04.1999). Informed consent to participate was obtained from the parents of infants involved in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/17 06:32 MHDA- 2026/06/17 06:33 PMCR- 2026/06/16 CRDT- 2026/06/17 00:06 PHST- 2026/03/27 00:00 [received] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/06/17 06:33 [medline] PHST- 2026/06/17 06:32 [pubmed] PHST- 2026/06/17 00:06 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 10.1186/s12903-026-08851-0 [pii] AID - 8851 [pii] AID - 10.1186/s12903-026-08851-0 [doi] PST - epublish SO - BMC Oral Health. 2026 Jun 16;26(1):1064. doi: 10.1186/s12903-026-08851-0. PMID- 42304271 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 16 TI - Base deficit and alactic base excess are promising early biological markers in pediatric sepsis. LID - 10.1186/s12887-026-07152-3 [doi] LID - 712 AB - BACKGROUND AND AIMS: The diagnosis and management of pediatric sepsis remain challenging and time-sensitive. Early biological markers that may identify patients at risk of progression to septic shock are needed. Base deficit (BD) has been associated with adverse outcomes in adult sepsis, while alactic base excess (ABE) reflects non-lactate metabolic acidosis. This study aimed to evaluate the performance of BD and ABE compared with lactate in pediatric sepsis and to assess their association with time to progression to septic shock. METHODS: This retrospective single-center cohort study included pediatric patients with sepsis between January 1, 2020, and September 1, 2024. Biomarkers were obtained at initial presentation prior to resuscitation. BD and ABE were categorized into normal, abnormal, and extremely abnormal groups based on distribution thresholds, while lactate was classified as normal (2.2 mmol/L). Diagnostic performance was assessed using ROC curve analysis. Time-to-event analyses were performed using Kaplan-Meier curves and multivariable Cox regression models adjusted for BMI, CRP, albumin, and Phoenix Sepsis Score. RESULTS: A total of 44 patients were included, of whom 30 (68.18%) developed septic shock. Lactate demonstrated lower discriminative performance (AUC 0.624, 95% CI 0.447-0.800) compared with BD (AUC 0.940, 95% CI 0.875-0.999) and ABE (AUC 0.905, 95% CI 0.813-0.997). Both BD and ABE showed higher sensitivity and specificity for identifying patients who progressed to septic shock. In adjusted analyses, abnormal and extremely abnormal ABE and BD were associated with an increased hazard of progression to septic shock. Median time to shock was shortest in patients with extremely abnormal BD and ABE (approximately 8-9 hours), followed by abnormal lactate (13 hours), abnormal ABE (17 hours), and abnormal BD (18 hours). CONCLUSIONS: BD and ABE were associated with progression to septic shock in pediatric sepsis and may provide clinically relevant information for early risk stratification. In this cohort, these markers demonstrated stronger discriminative performance than lactate and may reflect metabolic disturbances present earlier in the disease course. However, these findings should be interpreted cautiously given the retrospective design and require prospective multicenter validation before clinical implementation. CI - (c) 2026. The Author(s). FAU - Assaad, Amani AU - Assaad A AD - Division of Pediatric Critical Care Medicine, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon. FAU - Majdalani, Marianne AU - Majdalani M AD - Division of Pediatric Critical Care Medicine, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon. FAU - Ismail, Ali AU - Ismail A AD - Division of Pediatric Critical Care Medicine, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon. FAU - Moukhaiber, Jihane AU - Moukhaiber J AUID- ORCID: 0009-0008-4370-9809 AD - Division of Pediatric Critical Care Medicine, Department of Pediatrics and Adolescent Medicine, American University of Beirut Medical Center, Beirut, Lebanon. jm88@aub.edu.lb. LA - eng PT - Journal Article DEP - 20260616 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 0 (Biomarkers) RN - 33X04XA5AT (Lactic Acid) SB - IM MH - Humans MH - Biomarkers/blood MH - Retrospective Studies MH - Female MH - *Sepsis/blood/diagnosis/complications MH - Male MH - Child MH - *Lactic Acid/blood MH - Shock, Septic/diagnosis/blood/etiology MH - Child, Preschool MH - Disease Progression MH - Infant MH - ROC Curve MH - *Acid-Base Imbalance/diagnosis/blood PMC - PMC13445687 OTO - NOTNLM OT - Alactic base excess. OT - Base deficit OT - Lactate OT - Pediatrics OT - Sepsis OT - Septic shock COIS- Declarations. Ethical approval and consent to participate: The Institutional Review Board at AUBMC approved this study (BIO-2024-0043) on October 24, 2024, in accordance with the ethical principles of Belmont, 1979. Waiver for consent was approved by the Institutional Review Board as this is a retrospective observational study, and the research team are not involved in the clinical care of the collected patients. The waiver did not adversely affect the rights or welfare of the subjects, as their information was coded and handled with confidentiality, ensuring privacy and compliance with the ethical standards. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/17 06:32 MHDA- 2026/08/06 11:36 PMCR- 2026/06/16 CRDT- 2026/06/17 00:05 PHST- 2025/08/22 00:00 [received] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/08/06 11:36 [medline] PHST- 2026/06/17 06:32 [pubmed] PHST- 2026/06/17 00:05 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 10.1186/s12887-026-07152-3 [pii] AID - 7152 [pii] AID - 10.1186/s12887-026-07152-3 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 16;26(1):712. doi: 10.1186/s12887-026-07152-3. PMID- 42304257 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260917 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 16 TI - Cross-cultural adaptation of the Spanish version of the Swimming with Independent Measure (SWIM). LID - 10.1186/s12887-026-07054-4 [doi] LID - 796 AB - BACKGROUND: Assessing aquatic functional abilities is essential for designing effective interventions for children and adolescents who undergo aquatic activities and/or therapy. However, there is a lack of validated instruments in Spanish addressing this need. The Swimming with Independent Measure (SWIM) assesses functional performance in aquatic environments across typical and atypical development. This study aimed to cross-culturally adapt and to evaluate content equivalence and face validity of the SWIM for use with Spanish-speaking professionals working in aquatic environments with children and adolescents. METHOD: A methodological study was conducted to perform the cross-cultural adaptation of the SWIM and evaluate its content equivalence and face validity. Cross-cultural adaptation followed Beaton's six-phase methodology: translation, synthesis, back-translation, expert committee review, and pilot testing. Two translators and two back-translators performed the linguistic adaptation. A multidisciplinary expert committee (n = 5) evaluated content equivalence, and 20 professionals meeting predefined eligibility criteria participated in pilot testing. Content equivalence was assessed during the expert committee review, while face validity was evaluated during pilot testing. RESULTS: After two expert committee rounds, 83.6% of items were classified as conceptually equivalent and 16.4% as similar. Content equivalence indices improved from Ave-CVI = 0.93 to 1.00 and UA-CVI = 0.73 to 1.00. Pilot testing with 20 professionals confirmed adequate comprehensibility, requiring minor revisions to a few items. The final Spanish version showed adequate content equivalence and satisfactory face validity. CONCLUSIONS: The Spanish version of the SWIM was cross-culturally adapted, demonstrating semantic, conceptual, idiomatic, and content equivalence with the original, and showed adequate face validity. CI - (c) 2026. The Author(s). FAU - Gavina-Barroso, Maria Isabel AU - Gavina-Barroso MI AUID- ORCID: 0000-0002-5685-7252 AD - Universidad Europea de Madrid. Faculty of Medicine, Health and Sports. Department of Physiotherapy. Campus de Villaviciosa, Calle Tajo s/n, Villaviciosa de Odon, Madrid, 28670, Spain. FAU - Pacheco-da-Costa, Soraya AU - Pacheco-da-Costa S AUID- ORCID: 0000-0002-2226-3560 AD - Universidad de Alcala. Faculty of Medicine and Health Sciences. Department of Nursing and Physiotherapy. Neuromusculoskeletal Physical Therapy in Stages of Life Research Group (FINEMEV). Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), Campus Universitario Externo, Autovia A2, km 33,200, Alcala de Henares, 28805, Spain. soraya.pacheco@uah.es. FAU - Rodriguez-Costa, Isabel AU - Rodriguez-Costa I AUID- ORCID: 0000-0002-6645-2187 AD - Universidad de Alcala. Faculty of Medicine and Health Sciences, Department of Nursing and Physical Therapy, Humanization in the Intervention of Physiotherapy for the Integral Attention to the People (HIPATIA) Research Group, Campus Universitario Externo, Autovia A2, km 33,200, Alcala de Henares, 28805, Spain. FAU - Garcia-Perez-de-Sevilla, Guillermo AU - Garcia-Perez-de-Sevilla G AUID- ORCID: 0000-0002-2689-1767 AD - Universidad Europea de Madrid. Faculty of Medicine, Health and Sports. Department of Physiotherapy, Campus de Villaviciosa, Calle Tajo s/n, Villaviciosa de Odon, Madrid, 28670, Spain. FAU - Martinez-Caro, Leticia AU - Martinez-Caro L AUID- ORCID: 0000-0003-3486-4678 AD - Faculty of Health Sciences, UNIR., Avda. de La Paz, 137, Logrono, La Rioja, 26006, Spain. FAU - Sanchez-Sanchez, Beatriz AU - Sanchez-Sanchez B AUID- ORCID: 0000-0002-0223-9707 AD - Universidad de Alcala. Faculty of Medicine and Health Sciences. Department of Nursing and Physiotherapy, Physiotherapy in Women's Health (FPSM) Research Group, Campus Universitario Externo, Autovia A2, km 33,200, Alcala de Henares, 28805, Spain. AD - Ramon y Cajal Institute of Health Research - IRYCIS, Hospital Universitario Ramon y Cajal, Madrid, 28034, Spain. LA - eng PT - Journal Article PT - Validation Study DEP - 20260616 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Swimming/physiology MH - *Cross-Cultural Comparison MH - Child MH - Reproducibility of Results MH - Adolescent MH - Translations MH - Spain MH - Male MH - Female MH - Pilot Projects PMC - PMC13520382 OTO - NOTNLM OT - Aquatic functional abilities OT - Aquatic therapy OT - Content equivalence OT - Cross-cultural adaptation OT - Face validity OT - Halliwick concept OT - Motor function in water COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Hospital Clinico San Carlos Ethics Committee, under the reference number CI 19/495-E. All procedures were conducted in accordance with established ethical standards and relevant guidelines. Competing interests: The authors declare no competing interests. EDAT- 2026/06/17 06:32 MHDA- 2026/08/27 05:35 PMCR- 2026/06/16 CRDT- 2026/06/17 00:05 PHST- 2025/07/30 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/08/27 05:35 [medline] PHST- 2026/06/17 06:32 [pubmed] PHST- 2026/06/17 00:05 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 10.1186/s12887-026-07054-4 [pii] AID - 7054 [pii] AID - 10.1186/s12887-026-07054-4 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 16;26(1):796. doi: 10.1186/s12887-026-07054-4. PMID- 42302825 OWN - NLM STAT- Publisher LR - 20260616 IS - 1098-8785 (Electronic) IS - 0735-1631 (Linking) DP - 2026 Jun 16 TI - Association between Gestational Weight Gain and Neonatal Hypoxic and Traumatic Events: Results from a Large Retrospective Cohort. LID - 10.1055/a-2884-9010 [doi] AB - OBJECTIVE: Most of the published studies focus on the relationship between gestational weight gain (GWG) and maternal outcomes, and less so on the neonatal outcomes. Furthermore, optimal GWG ranges defined by the Institute of Medicine were challenged by research showing the benefits of smaller GWG for overweight and obese mothers. Therefore, we intended to assess whether there is an association between GWG and hypoxic or traumatic events in the neonate, especially among overweight and obese mothers, as we sought the best methodological approach to study GWG. STUDY DESIGN: We used the Consortium on Safe Labor data, a retrospective cohort study collecting pregnancy data from 2002 to 2008 in 12 U.S. centers. The association between GWG and neonatal morbidity was estimated in singleton gestations >/= 37 weeks' gestation using binomial logistic regression models. GWG was analyzed as a continuous linear, continuous quadratic, categorical, and binary variable. The Hosmer-Lemeshow test (HL) assessed calibration of the models, the Brier score evaluated calibration and the overall model performance, whereas the area under the receiver-operating characteristic curve (AUC) measured discrimination. RESULTS: Among 104,599 mothers 24,609 (23.5%) were overweight and 19,324 (18.5%) obese; 7,974 (7.6%) infants experienced hypoxic, whereas 2,031 (1.9%) developed traumatic morbidity. The risk of infant morbidity increased with GWG, with thresholds of 6 to 23 kg for ischemic events, and 4 to 21 kg for traumatic events (p < 0.05). Multivariable models showed adequate calibration for traumatic, and for hypoxic events, the latter only when GWG was analyzed as a quadratic or categorical variable (HL tests, p > 0.01). In contrast, discrimination was poor for all models (AUCs 0.05). Gender-specific analysis revealed significant differences between the control group and all three AIS subgroups in women (p < 0.05), while in males, significant differences were seen solely between the mild and moderate AIS groups and the control group (p < 0.05). CONCLUSION: The results of this study suggest elevated 2D:4D ratios may signify reduced androgen or increased estrogen exposure during the prenatal phase and are correlated with AIS. The 2D:4D ratio may function as an economical, non-invasive biomarker for AIS. Subsequent research should investigate the viability of this biomarker for clinical screening and therapeutic strategizing. This work is among the first in the literature to assess the 2D:4D ratio in relation to AIS, indicating its potential to significantly enhance the existing body of research. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Isik, Mustafa AU - Isik M AD - Department of Orthopedics and Traumatology, School of Medicine, Gaziantep University, Gaziantep, Turkey. FAU - Unat, Beytullah AU - Unat B AD - Department of Orthopedics and Traumatology, School of Medicine, Gaziantep Islam Science and Technology University, Gaziantep, Turkey. FAU - Gonder, Nevzat AU - Gonder N AD - Department of Orthopedics and Traumatology, School of Medicine, Gaziantep University, Gaziantep, Turkey. FAU - Kaya, Onur AU - Kaya O AD - Department of Orthopaedics and Traumatology, Gaziantep City Hospital, Gaziantep, Turkey. FAU - Ozturk, Cansu AU - Ozturk C AD - Department of Anatomy, School of Medicine, Gaziantep Islam Science and Technology University, Gaziantep, Turkey; Gaziantep University Graduate School of Health Sciences, Gaziantep, Turkey. FAU - Tasdemir, Rabia AU - Tasdemir R AD - Department of Anatomy, School of Medicine, Gaziantep Islam Science and Technology University, Gaziantep, Turkey. Electronic address: rabia.tasdemir@gibtu.edu.tr. LA - eng PT - Journal Article DEP - 20260610 PL - Ireland TA - Early Hum Dev JT - Early human development JID - 7708381 SB - IM MH - Humans MH - *Scoliosis/diagnostic imaging/epidemiology MH - Adolescent MH - Female MH - Child MH - Male MH - *Fingers/diagnostic imaging/anatomy & histology MH - *Digit Ratios MH - Case-Control Studies MH - Retrospective Studies MH - Cross-Sectional Studies OTO - NOTNLM OT - 2D:4D ratio OT - Adolescent idiopathic scoliosis OT - Biomarker OT - Cobb angle OT - Prenatal hormones COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/17 00:36 MHDA- 2026/09/04 23:36 CRDT- 2026/06/16 18:07 PHST- 2026/04/27 00:00 [received] PHST- 2026/06/08 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/09/04 23:36 [medline] PHST- 2026/06/17 00:36 [pubmed] PHST- 2026/06/16 18:07 [entrez] AID - S0378-3782(26)00133-7 [pii] AID - 10.1016/j.earlhumdev.2026.106608 [doi] PST - ppublish SO - Early Hum Dev. 2026 Nov;222:106608. doi: 10.1016/j.earlhumdev.2026.106608. Epub 2026 Jun 10. PMID- 42302445 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260907 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 90 DP - 2026 Sep-Oct TI - Adaptation of the Mindful Eating Scale to Turkish for the adolescent population: A validity and reliability study. PG - 184-192 LID - S0882-5963(26)00275-7 [pii] LID - 10.1016/j.pedn.2026.06.010 [doi] AB - PURPOSE: This study aimed to examine the psychometric properties of the Turkish version of the Mindful Eating Scale among adolescents. METHOD: The research was conducted methodologically with a sample of 800 adolescents. Data were collected using a Sociodemographic Information Form and the Mindful Eating Scale. Statistical analyses included language, content, and construct validity (Confirmatory Factor Analysis), as well as internal consistency and test-retest reliability. RESULTS: The mean age of the adolescents participating in the study was 15.72 +/- 0.87. the final scale consisted of 24 item and six sub-dimensions. Of the adolescents, 94.3% did not have any nutrition-related diseases, 58.1% had knowledge about mindful eating, and 83.3% had not received nutrition education. Factor loadings of the scale were found to range between 0.317 and 0.846. All items significantly contributed to their respective factors. Fit indices were found to be chi2/df = 3.489, GFI = 0.91, IFI = 0.90, CFI = 0.90, RMSEA = 0.05, and SRMR = 0.06. These values indicate that the scale's fit is acceptable and at a good level. Cronbach's alpha coefficient of the scale was 0.78, indicating good internal consistency. CONCLUSION: The Mindful Eating Scale, presented in its Turkish version, is a valid and reliable tool. It can be effectively used by school counselors, dietitians, pediatric nurses and healthcare providers and researchers to assess nutritional behaviors in adolescent populations and develop mindful awareness-based interventions. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Arslan, Nurten AU - Arslan N AD - Department of Pediatric Nursing, Faculty of Health Sciences, Zonguldak Bulent Ecevit University, Zonguldak, Turkey. Electronic address: nurten.arslan@beun.edu.tr. FAU - Kurtuncu, Meltem AU - Kurtuncu M AD - Department of Pediatric Nursing, Faculty of Health Sciences, Zonguldak Bulent Ecevit University, Zonguldak, Turkey. FAU - Celik, Melike Yavas AU - Celik MY AD - Department of Midwifery, Faculty of Health Sciences, Gazianetep University, Turkey. LA - eng PT - Journal Article PT - Validation Study DEP - 20260616 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM MH - Humans MH - Adolescent MH - Turkey MH - Reproducibility of Results MH - Female MH - Psychometrics MH - Male MH - Surveys and Questionnaires MH - *Mindfulness MH - *Feeding Behavior/psychology MH - *Adolescent Behavior/psychology OTO - NOTNLM OT - Adolescent OT - Adolescent nutrition OT - Awareness OT - Mindful eating OT - Psychometric properties OT - Validity and reliability COIS- Declaration of competing interest There is no conflict of interest between the authors. EDAT- 2026/06/17 00:36 MHDA- 2026/09/07 23:34 CRDT- 2026/06/16 18:04 PHST- 2026/01/07 00:00 [received] PHST- 2026/06/09 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/09/07 23:34 [medline] PHST- 2026/06/17 00:36 [pubmed] PHST- 2026/06/16 18:04 [entrez] AID - S0882-5963(26)00275-7 [pii] AID - 10.1016/j.pedn.2026.06.010 [doi] PST - ppublish SO - J Pediatr Nurs. 2026 Sep-Oct;90:184-192. doi: 10.1016/j.pedn.2026.06.010. Epub 2026 Jun 16. PMID- 42301711 OWN - NLM STAT- MEDLINE DCOM- 20260616 LR - 20260827 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 9 IP - 6 DP - 2026 Jun 1 TI - Sociodemographic, Health Care, and Clinical Factors Associated With Metabolic Bariatric Surgery Uptake Among US Adults With Obesity. PG - e2618686 LID - 10.1001/jamanetworkopen.2026.18686 [doi] LID - e2618686 AB - IMPORTANCE: Metabolic bariatric surgery (MBS) is a highly effective but underused treatment for obesity. Greater understanding of diagnosis and referral pathways are needed to help inform appropriate treatment options for obesity. OBJECTIVE: To examine factors associated with uptake of MBS among individuals with incident obesity diagnosis. DESIGN, SETTING, AND PARTICIPANTS: This cohort study used insurance claims data from the Merative MarketScan Commercial Claims and Encounters Database to identify a cohort of individuals aged 18 to 64 years with an incident obesity diagnosis (index) in inpatient and outpatient settings between January 1, 2018, and December 31, 2022, as well as MBS uptake within 12 months of index to December 31, 2023. EXPOSURES: Diagnoses classified using Agency for Healthcare Research and Quality Clinical Classifications Software Refined and therapeutic classes (Red Book) of drugs taken within the 12-month period prior to index date, as well as sociodemographic and health care factors determined at the index date. MAIN OUTCOMES AND MEASURES: Factors associated with MBS uptake were examined using machine learning methods and multivariable logistic regression. Exclusion criteria included pregnancy-related visits; missing International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, body mass index (BMI) Z-code; or prior MBS. The top 25 factors identified by a random forest model were ranked by Shapley Additive Explanation (SHAP) values, and odds ratios (ORs) were estimated for each top factor in a multivariable logistic regression model. RESULTS: In this study of 109 849 individuals (mean [SD] age, 41.4 [11.8] years; 63 992 women [58.3%]) with an initial obesity diagnosis, 3268 (3.0%) received MBS within 12 months of index. The area under the receiver operating characteristic curve score was 0.88 (95% CI, 0.87-0.90). The top factors identified by the random forest model included surgeon (not elsewhere classified [NEC]) as provider (which includes medical institutions and organizations as well as health care professionals) (mean SHAP value, 0.00918 [95% CI, 0.00893-0.00945]), BMI category (mean SHAP value, 0.00501 [95% CI, 0.00499-0.00503]), family practice as provider (mean SHAP value, 0.00372 [95% CI, 0.00370-0.00374]), and female sex (mean SHAP value, 0.00370 [95% CI, 0.00368-0.00371]). Surgeon (NEC) as provider had the largest OR (18.97 [95% CI, 17.11-21.02]), followed by other provider types (orthopedic surgeon: OR, 5.33 [95% CI, 4.54-6.24]; dietitian: OR, 2.51 [95% CI, 1.97-3.20]). Several medication (antidiabetic agents, miscellaneous: OR, 1.42 [95% CI, 1.25-1.62]; psychotherapeutics, antidepressants: OR, 1.13 [95% CI, 1.01-1.25]), diagnostic (depressive disorders: OR, 1.16 [95% CI, 1.02-1.33]), and sociodemographic variables (female sex: OR, 2.45 [95% CI, 2.22-2.71]) were also significantly associated with MBS. There was a significant decrease in MBS uptake for individuals with incident obesity diagnosis in more recent year-quarters from 2019 through 2022. CONCLUSIONS AND RELEVANCE: In this cohort study of individuals with an initial obesity diagnosis, uptake of MBS was patterned by demographic, clinical, and health care factors. This finding suggests substantial opportunity to improve access to MBS through targeted policies and interventions. FAU - Raquib, Rafeya V AU - Raquib RV AD - Department of Global Health, Boston University School of Public Health, Boston, Massachusetts. FAU - Tokarski, Allison AU - Tokarski A AD - Johnson & Johnson MedTech, Cincinnati, Ohio. FAU - Doshi, Ishita AU - Doshi I AD - Johnson & Johnson MedTech, Raritan, New Jersey. FAU - Afolabi, Mosadoluwa AU - Afolabi M AD - Johnson & Johnson MedTech, New Brunswick, New Jersey. FAU - Tomaszewski, Jorg AU - Tomaszewski J AD - Johnson & Johnson MedTech, Raritan, New Jersey. FAU - Johnston, Stephen AU - Johnston S AD - Johnson & Johnson MedTech, New Brunswick, New Jersey. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260601 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Humans MH - *Bariatric Surgery/statistics & numerical data MH - Female MH - Adult MH - *Obesity/surgery/epidemiology MH - United States/epidemiology MH - Middle Aged MH - Male MH - Adolescent MH - Young Adult MH - Cohort Studies MH - Socioeconomic Factors PMC - PMC13273493 COIS- Conflict of Interest Disclosures: Ms Tokarski reported being an employee of Johnson & Johnson Inc during the conduct of the study. Ms Doshi reported being an employee and stockholder of Johnson & Johnson Inc. Ms Afolabi reported being an employee of Johnson & Johnson Inc during the conduct of the study. Dr Tomaszewski reported being an employee and shareholder of Johnson & Johnson MedTech Surgery. Dr Johnston reported being an employee of Johnson & Johnson during the conduct of the study. No other disclosures were reported. EDAT- 2026/06/16 13:32 MHDA- 2026/06/16 13:33 PMCR- 2026/06/16 CRDT- 2026/06/16 11:33 PHST- 2026/06/16 13:33 [medline] PHST- 2026/06/16 13:32 [pubmed] PHST- 2026/06/16 11:33 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - 2850418 [pii] AID - zoi260521 [pii] AID - 10.1001/jamanetworkopen.2026.18686 [doi] PST - epublish SO - JAMA Netw Open. 2026 Jun 1;9(6):e2618686. doi: 10.1001/jamanetworkopen.2026.18686. PMID- 42299688 OWN - NLM STAT- Publisher LR - 20260616 IS - 1477-0873 (Electronic) IS - 0269-2155 (Linking) DP - 2026 Jun 16 TI - Trajectories of physical fitness following paediatric burn injury: A two-year longitudinal and predictive analysis. PG - 2692155261459618 LID - 10.1177/02692155261459618 [doi] AB - ObjectiveTo analyse physical fitness trajectories in paediatric burn survivors from discharge to 2 years post-injury, compare them with an age- and gender-matched control group, and identify baseline demographic and clinical determinants.DesignProspective and longitudinal cohort study.ParticipantsThe study included participants with burn injuries (burn group, n = 45), aged 10-17 years, with burns involving >/=25% of total body surface area, and an age- and gender-matched group of healthy children (control group, n = 45).Main measuresParticipants underwent standardised fitness assessments at discharge and 24 months later. Health-related physical fitness was quantitatively assessed using the validated EUROFIT physical fitness test battery.ResultsLongitudinal analysis revealed significant improvements in seven of nine fitness domains for participants with burn injuries over two years (pFDR < 0.001). Despite these gains, these participants exhibited persistent fitness deficits compared to healthy controls across all domains at follow-up (all p < 0.001). Among those with burn injuries, greater total body surface area (beta = -0.007, p = 0.03) and third-degree burn percentage (beta = -0.57, p < 0.001) predicted lower overall fitness, while longer rehabilitation predicted higher fitness (beta = 0.50, p < 0.001). No baseline clinical factors significantly predicted the rate of fitness change over time (all interaction p > 0.05).ConclusionPaediatric burn survivors demonstrated significant improvements in physical fitness over 2 years but failed to close the performance gap with their healthy peers. Injury severity and rehabilitation duration were strong determinants of fitness level, but they did not predict the rate of improvement. FAU - Basha, Maged A AU - Basha MA AUID- ORCID: 0000-0002-3422-6193 AD - Department of Physical Therapy, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia. RINGGOLD: 89660 FAU - Elnaggar, Ragab K AU - Elnaggar RK AUID- ORCID: 0000-0001-5080-702X AD - Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia. RINGGOLD: 63526 AD - Department of Physical Therapy for Pediatrics, Faculty of Physical Therapy, Cairo University, Giza, Egypt. RINGGOLD: 531226 FAU - Aloraini, Saleh M AU - Aloraini SM AUID- ORCID: 0000-0001-7939-8098 AD - Department of Physical Therapy, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia. RINGGOLD: 89660 FAU - Alsultan, Feras AU - Alsultan F AUID- ORCID: 0000-0002-3470-8272 AD - Department of Physical Therapy, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia. RINGGOLD: 89660 FAU - Alharbi, Amal AU - Alharbi A AUID- ORCID: 0009-0008-7260-5486 AD - Department of Physical Therapy, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia. RINGGOLD: 89660 FAU - Alqahtani, Ashwaq AU - Alqahtani A AD - Department of Physical Therapy, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia. RINGGOLD: 89660 FAU - El-Keblawy, Mohamed Maher AU - El-Keblawy MM AUID- ORCID: 0000-0003-1588-7452 AD - Department of Research on Children with Special Needs, National Research Center, Cairo, Egypt. RINGGOLD: 68787 FAU - Azab, Alshimaa R AU - Azab AR AUID- ORCID: 0000-0002-9533-0699 AD - Department of Health and Rehabilitation Sciences, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia. RINGGOLD: 63526 AD - Department of Physical Therapy for Pediatrics, Faculty of Physical Therapy, Cairo University, Giza, Egypt. RINGGOLD: 531226 FAU - Kamel, FatmaAlzahraa H AU - Kamel FH AUID- ORCID: 0000-0003-1546-6666 AD - Department of Physical Therapy, College of Applied Medical Sciences, Qassim University, Buraydah, Saudi Arabia. RINGGOLD: 89660 AD - Department of Physical Therapy for Surgery, Faculty of Physical Therapy, Cairo University, Giza, Egypt. RINGGOLD: 531226 LA - eng PT - Journal Article DEP - 20260616 PL - England TA - Clin Rehabil JT - Clinical rehabilitation JID - 8802181 SB - IM OTO - NOTNLM OT - Paediatric burn injury OT - health-related physical fitness OT - longitudinal and predictive analysis OT - rehabilitation EDAT- 2026/06/16 06:35 MHDA- 2026/06/16 06:35 CRDT- 2026/06/16 05:14 PHST- 2026/06/16 06:35 [medline] PHST- 2026/06/16 06:35 [pubmed] PHST- 2026/06/16 05:14 [entrez] AID - 10.1177/02692155261459618 [doi] PST - aheadofprint SO - Clin Rehabil. 2026 Jun 16:2692155261459618. doi: 10.1177/02692155261459618. PMID- 42298961 OWN - NLM STAT- Publisher LR - 20260708 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) DP - 2026 Jun 16 TI - Diet quality and risk of using medication for hypertension up to 11 years after delivery: testing the predictive validity of a proposed revision of the Nutri-Score and the current Nutri-Score in the NewTools project. PG - 1-9 LID - 10.1017/S0007114526107697 [doi] AB - The aim of this study was to investigate the predictive validity of a proposed revision of the Nutri-Score and the current Nutri-Score by investigating associations between the diet quality scores measured in mid-pregnancy and the risk of dispensed prescription of medications for hypertension up to 11 years following delivery and blood pressure mid-pregnancy. The study population (n 70 730) were participants in the Norwegian Mother, Father and Child Cohort Study. Food intake was assessed in mid-pregnancy using a validated FFQ. Nutritional scores for each food item were calculated based on content of energy, sugars, saturated fat, salt, fibre, protein, fruit, vegetables and legumes. Diet quality scores were derived using energy-weighted means of nutritional scores. Anti-hypertensive medications were registered in the national prescription database. We estimated hazard ratios (HRs) with 95 % CIs using Cox regression models. During a mean follow-up of 6 years, 4736 (6.7 %) women were dispensed prescription for medications for hypertension. There was a non-linear association between diet quality and hypertension medication. Compared with the median diet quality score, poorer diet quality (90th percentile of the score) was associated with higher risk of medications for hypertension (HR = 1.08, 95 % CI 1.02, 1.14) and cross-sectional high diastolic blood pressure (OR = 1.18, 95 % CI 1.03, 1.32). Both diet quality scores yielded similar results overall. Poorer diet quality during pregnancy, assessed with a proposed version, and the current Nutri-Score, was associated with a higher risk of medications for hypertension, indicating its usefulness as a valuable tool for guiding consumers and improving public health. FAU - Amberntsson, Anna AU - Amberntsson A AUID- ORCID: 0000-0003-3510-9789 AD - Department of Food Safety, https://ror.org/046nvst19Norwegian Institute of Public Health, Norway. AD - Centre for Sustainable Diets, https://ror.org/046nvst19Norwegian Institute of Public Health, Norway. FAU - Abel, Marianne Hope AU - Abel MH AD - Centre for Sustainable Diets, https://ror.org/046nvst19Norwegian Institute of Public Health, Norway. AD - Centre for Evaluation of Public Health Measures, Norwegian Institute of Public Health, Norway. AD - Department of Physical Health and Ageing, Norwegian Institute of Public Health, Norway. FAU - Paulsen, Mari Mohn AU - Paulsen MM AD - Department of Food Safety, https://ror.org/046nvst19Norwegian Institute of Public Health, Norway. AD - Centre for Sustainable Diets, https://ror.org/046nvst19Norwegian Institute of Public Health, Norway. FAU - Andersen, Lene Frost AU - Andersen LF AD - Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Norway. FAU - Oyen, Jannike AU - Oyen J AD - Department of Seafood and Nutrition, Institute of Marine Research, Norway. AD - Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Norway. FAU - Rosendahl-Riise, Hanne AU - Rosendahl-Riise H AUID- ORCID: 0000-0002-1497-416X AD - Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Norway. FAU - Brantsaeter, Anne Lise AU - Brantsaeter AL AUID- ORCID: 0000-0001-6315-7134 AD - Department of Food Safety, https://ror.org/046nvst19Norwegian Institute of Public Health, Norway. AD - Centre for Sustainable Diets, https://ror.org/046nvst19Norwegian Institute of Public Health, Norway. LA - eng PT - Journal Article DEP - 20260616 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM OTO - NOTNLM OT - Food rating system OT - Front-of-pack nutrition label OT - MoBa OT - Nutri-Score OT - Nutrient profiling OT - Nutritional quality OT - Predictive validity EDAT- 2026/06/16 06:35 MHDA- 2026/06/16 06:35 CRDT- 2026/06/16 02:43 PHST- 2026/06/16 06:35 [pubmed] PHST- 2026/06/16 06:35 [medline] PHST- 2026/06/16 02:43 [entrez] AID - S0007114526107697 [pii] AID - 10.1017/S0007114526107697 [doi] PST - aheadofprint SO - Br J Nutr. 2026 Jun 16:1-9. doi: 10.1017/S0007114526107697. PMID- 42298737 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260821 LR - 20260823 IS - 2055-5784 (Print) IS - 2055-5784 (Electronic) IS - 2055-5784 (Linking) VI - 12 IP - 1 DP - 2026 Jun 15 TI - GAIN: a multicenter pilot protocol for early initiation of enteral feeds in neonates with simple gastroschisis. LID - 10.1186/s40814-026-01860-4 [doi] LID - 123 AB - BACKGROUND: Gastroschisis is a congenital abdominal wall defect characterized by severe gut dysmotility. These neonates often face lengthy hospital stays, prolonged parenteral nutrition dependence, and complications such as growth faltering, sepsis, and intestinal failure. Feeding practices for neonates with gastroschisis vary and emphasize extended bowel rest and delayed feeding initiation. Usual practices in determining timing to start feeds include awaiting return of bowel function which typically consists of low Replogle output volume, color changing from bilious to clear and/or passing stool. However, emerging studies suggest that early initiation of feeds through standardized protocols may improve outcomes. The Gastroschisis And Early Infant Nutrition (GAIN) Study aims to test the feasibility of an early feeding approach in neonates with simple gastroschisis. METHODS: This two-site single-arm feasibility trial aims to enroll neonates with presumed simple gastroschisis over 30 months. The intervention has two main components: Replogle suction tube removal within 24 h of abdominal closure and starting small-volume human milk feeds within 48 h of abdominal closure. Feeding volume will be advanced as tolerated, following the University of California Fetal Consortium pathway, which is standard care. Feasibility outcomes include enrollment rate, protocol adherence, fidelity, and withdrawal rate. Exploratory outcomes include hospitalization length, time to full feeds, duration of parenteral nutrition, use of human milk, breastfeeding rates, and anthropometric measurements. Safety measures involve monitoring for feeding-related complications, infections, and unexpected surgical interventions. DISCUSSION: This feasibility trial of early feeding initiation in neonates with gastroschisis is a critical step towards addressing the need for a standardized feeding approach. Findings will inform future clinical trials and challenge the need for prolonged bowel rest. Standardizing early feeding practices could reduce practice variation, improve gut motility, and the overall health of neonates with gastroschisis. SYSTEMATIC REVIEW REGISTRATION: NCT06878950. CI - (c) 2026. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. FAU - Cacho, Nicole T AU - Cacho NT AD - Department of Pediatrics, University of California Davis, Sacramento, CA, 95817, USA. FAU - Cera, Anjali J AU - Cera AJ AD - Department of Pediatrics, Kaiser Permanente, Roseville, CA, 95661, USA. FAU - Tancredi, Daniel J AU - Tancredi DJ AD - Department of Pediatrics, University of California Davis, Sacramento, CA, 95817, USA. FAU - Wieck, Minna M AU - Wieck MM AD - Department of Surgery, University of California Davis, Sacramento, CA, 95817, USA. FAU - Anderson, Jamie E AU - Anderson JE AD - Department of Surgery, University of California Davis, Sacramento, CA, 95817, USA. FAU - Leegwater, Alexandra J AU - Leegwater AJ AD - Department of Pediatrics, University of California Davis, Sacramento, CA, 95817, USA. FAU - Uy, Cherry C AU - Uy CC AD - Department of Pediatrics, University of California, Irvine, Irvine, CA, 92697, USA. FAU - Guner, Yigit S AU - Guner YS AD - Department of Surgery, Children's Hospital of Orange County, Orange, CA, 92868, USA. FAU - DeUgarte, Daniel A AU - DeUgarte DA AD - Department of Surgery, University of California, Los Angeles, CA, 90095, USA. FAU - Rosenthal, Jennifer L AU - Rosenthal JL AD - Department of Pediatrics, University of California Davis, Sacramento, CA, 95817, USA. FAU - Calkins, Kara L AU - Calkins KL AD - Department of Pediatrics, University of California, Los Angeles, CA, 90095, USA. FAU - Bautista, Geoanna M AU - Bautista GM AUID- ORCID: 0000-0003-0245-9272 AD - Department of Pediatrics, University of California Davis, Sacramento, CA, 95817, USA. gmbautista@health.ucdavis.edu. CN - University of California Fetal Consortium (UCfC) LA - eng SI - ClinicalTrials.gov/NCT06878950 GR - K08 DK143334/DK/NIDDK NIH HHS/United States GR - KL2 TR001859/TR/NCATS NIH HHS/United States GR - L40 DK137356/DK/NIDDK NIH HHS/United States GR - UL1 TR001860/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20260615 PL - England TA - Pilot Feasibility Stud JT - Pilot and feasibility studies JID - 101676536 PMC - PMC13495323 OTO - NOTNLM OT - Early feeds OT - Feasibility trial OT - Gastroschisis OT - Neonatal intensive care unit OT - Rare disease COIS- Declarations. Ethics approval and consent to participate: If the parent is eligible and agrees to participate, they must sign a paper consent form within the first 24 h of abdominal closure. If signed during pregnancy, the infant will undergo additional screening at delivery to ensure they meet study criteria. The signed form, containing identifiable information, will be stored in a locked cabinet in the NICU, accessible only to study staff. A copy will be uploaded to the electronic medical records of either the mother, the infant, or both. Parents will receive a signed copy for their records. Obtaining local IRB-approved informed consent is a basic ethical obligation and a legal requirement for researchers unless waived by the IRB. Informed consent is a key protection defined by: HHS regulations at 45 CFR part 46 and FDA regulations at 21 CFR part 50. Competing interests: KLC has received research support from Fresenius Kabi, Mead Johnson, and Premier Research. KLC has served as an advisor for Fresenius Kabi, Mead Johnson, Baxter, and Prolacta. KLC serves as an institutional principal investigator, with no salary funding, for a consortium database sponsored by Mead Johnson. All other authors declare that they have no competing interests. FIR - Ong, Twila IR - Ong T FIR - Bedford-Mu, Christa IR - Bedford-Mu C FIR - Wright, Katy IR - Wright K FIR - Usher, Kenzie IR - Usher K EDAT- 2026/06/16 06:35 MHDA- 2026/06/16 06:36 PMCR- 2026/06/15 CRDT- 2026/06/16 00:49 PHST- 2025/09/10 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/06/16 06:36 [medline] PHST- 2026/06/16 06:35 [pubmed] PHST- 2026/06/16 00:49 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.1186/s40814-026-01860-4 [pii] AID - 1860 [pii] AID - 10.1186/s40814-026-01860-4 [doi] PST - epublish SO - Pilot Feasibility Stud. 2026 Jun 15;12(1):123. doi: 10.1186/s40814-026-01860-4. PMID- 42298718 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260825 LR - 20260827 IS - 1756-0381 (Print) IS - 1756-0381 (Electronic) IS - 1756-0381 (Linking) VI - 19 IP - 1 DP - 2026 Jun 15 TI - Clinically actionable classification tool for childhood and adult atopic dermatitis via explainable AI: a retrospective cross-sectional study optimizing diagnostic accuracy. LID - 10.1186/s13040-026-00565-x [doi] LID - 66 AB - BACKGROUND: Despite the critical role of early identification in managing atopic dermatitis (AD), current studies are limited by the absence of adult-specific risk stratification models and imbalanced cohort data, hindering effective risk profiling. OBJECTIVE: We aimed to address this deficiency by developing models for AD diagnostic classification through robust machine learning techniques, with a focus on integrating personalized risk factors to improve the identification and characterization of AD in both children and adults. METHODS: The study employed multiracial cross-sectional data from the National Health And Nutrition Examination Survey (NHANES) in which children (age < 20) and adults (age >/= 20) with self-reported AD endpoints were extracted from 1999 to 2006. Comprehensive class balancing and machine learning techniques were employed to develop a set of AD classification models for different age groups. The models were assessed using five-fold cross-validation for internal validation and internal hold-out validations using a test set composed of raw data. The optimal model for each subgroup, with the best accuracy to classify AD presence, was determined and assessed by ACC, F1-score, MCC, and ROC curve. Key features and their contributions to each classification decision are interpreted by permutation feature importance (PFI) and SHapley Additive explanations (SHAP). We compared and further analyzed demographic and nutritional indicators that have significant associations. RESULTS: Of 22,635 qualified participants, 1118 (13.47%) children and 1732 (12.80%) adults were identified as having AD. The pronounced class imbalance within the dataset led to baseline models yielding accuracies in the range of merely 0.500-0.503. Following the implementation of class balancing techniques and diverse modeling methods, the refined model, utilizing accessible variables from both children and adults, achieved markedly enhanced performance (ACC: 0.835-0.885, F1-score: 0.834-0.884, AUC: 0.913-0.957). Explainable AI revealed opposing effects of dietary antioxidants between children and adults, highlighting age-specific associated mechanisms. CONCLUSION: The classification models for both childhood and adult AD have demonstrated robust discriminative ability and potential utility for case identification in both internal and internal hold-out validations. These models address the challenge in accurate, individualized classification for childhood and adult AD, demonstrating strong discriminative potential in our validation cohorts. We have developed a novel AD diagnostic identification system specifically for both children and adults based on readily accessible demographic, clinical, and nutritional features, which enable the characterization of individuals with a high probability of having AD and the pinpointing of their associated features. This provides a methodological foundation for future research into early management strategies for AD, which could ultimately aim to minimize adverse impacts and modify disease progression. CI - (c) 2026. The Author(s). FAU - Zhou, Rong AU - Zhou R AD - Department of Dermatology, the Second Affiliated Hospital, The Domestic First-Class Discipline Construction Project of Hunan University of Chinese Medicine, Changsha, Hunan, 410005, China. FAU - Zhang, Weiming AU - Zhang W AD - Department of Dermatology, Wuhan No.1 Hospital, Wuhan, Hubei, 430022, China. FAU - Zhou, Lingyue AU - Zhou L AD - Institute of Innovation and Applied Research, Hunan University of Chinese Medicine, Changsha, 410208, China. FAU - Zhu, Qin AU - Zhu Q AD - Department of Dermatology, the Second Affiliated Hospital, The Domestic First-Class Discipline Construction Project of Hunan University of Chinese Medicine, Changsha, Hunan, 410005, China. FAU - Zhang, Jinqing AU - Zhang J AD - Department of Dermatology, the Second Affiliated Hospital, The Domestic First-Class Discipline Construction Project of Hunan University of Chinese Medicine, Changsha, Hunan, 410005, China. FAU - Wang, Shiyu AU - Wang S AD - Department of Dermatology, the Second Affiliated Hospital, The Domestic First-Class Discipline Construction Project of Hunan University of Chinese Medicine, Changsha, Hunan, 410005, China. FAU - Wang, Chang AU - Wang C AD - Department of Dermatology, the Second Affiliated Hospital, The Domestic First-Class Discipline Construction Project of Hunan University of Chinese Medicine, Changsha, Hunan, 410005, China. 2005040@hnucm.edu.cn. LA - eng PT - Journal Article DEP - 20260615 PL - England TA - BioData Min JT - BioData mining JID - 101319161 PMC - PMC13505055 OTO - NOTNLM OT - Atopic dermatitis OT - Class imbalance OT - Classification model OT - Explainable artificial intelligence OT - Machine learning COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/16 06:35 MHDA- 2026/06/16 06:36 PMCR- 2026/06/15 CRDT- 2026/06/16 00:48 PHST- 2025/12/03 00:00 [received] PHST- 2026/05/14 00:00 [accepted] PHST- 2026/06/16 06:36 [medline] PHST- 2026/06/16 06:35 [pubmed] PHST- 2026/06/16 00:48 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.1186/s13040-026-00565-x [pii] AID - 565 [pii] AID - 10.1186/s13040-026-00565-x [doi] PST - epublish SO - BioData Min. 2026 Jun 15;19(1):66. doi: 10.1186/s13040-026-00565-x. PMID- 42298498 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260909 IS - 1472-6874 (Electronic) IS - 1472-6874 (Linking) VI - 26 IP - 1 DP - 2026 Jun 15 TI - Health-promoting lifestyle among women living in suburban areas of northeastern Iran: A cross-sectional study. LID - 10.1186/s12905-026-04605-w [doi] LID - 423 AB - INTRODUCTION: Women, especially in urban marginalized areas, face a set of challenges and limitations in the field of health promotion. Considering the key role of women in family and community health, and their vulnerability in marginalized conditions, this study aimed to examine health-promoting lifestyle in women living in urban marginalized areas, to identify their needs and provide a foundation for designing evidence-based interventions and effective policies to improve women's health. METHODS: This cross-sectional, descriptive-analytical study was conducted in 2025 on 295 women living in a suburban area of Mashhad, northeastern Iran, using multi-stage sampling. After ethical approval and written informed consent, participants completed a demographic questionnaire and the Health-Promoting Lifestyle Profile II (HPLP-II), whose Persian version has confirmed validity and reliability in Iran (Cronbach's alpha = 0.82). Data were analyzed in SPSS version 25 using descriptive and analytical statistics including Kruskal-Wallis, Mann-Whitney U, and Spearman correlation tests with a significance level of p < 0.05. RESULTS: The mean age of the women was 37.25 +/- 10.63 years and mean total health-promoting lifestyle score was 127.87 +/- 26.91, with the highest mean score in the spiritual growth dimension (26.02 +/- 5.58). Analyses showed a significant inverse relationship between age, number of children, BMI, and lifestyle score (P < 0.05), and lower lifestyle scores among women with chronic diseases such as hypertension and hyperlipidemia (P < 0.05). A significant increase in lifestyle score with higher family income (P < 0.05), and differences in mean lifestyle scores based on marital status and educational level (P < 0.05). DISCUSSION AND CONCLUSION: The findings indicate that the overall level of health-promoting lifestyle among women living in marginalized areas is moderate and associated with various individual and social factors. These findings suggest that improving women's health in such settings requires attention to both personal behaviors and broader economic and educational contexts. Further studies are recommended to design and assess interventions that effectively address these factors. CI - (c) 2026. The Author(s). FAU - Rastgoo, Faezeh AU - Rastgoo F AD - Student Research Committee, Faculty of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Davoudi, Nayyereh AU - Davoudi N AD - Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Najafi, Samane AU - Najafi S AD - Student Research Committee, Faculty of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Talab, HamidReza Zendeh AU - Talab HZ AD - Department of Community Health Nursing, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran. zendehtalabhr@mums.ac.ir. LA - eng GR - 4040112/Mashhad University of Medical Sciences/ PT - Journal Article DEP - 20260615 PL - England TA - BMC Womens Health JT - BMC women's health JID - 101088690 SB - IM MH - Humans MH - Female MH - Iran MH - Cross-Sectional Studies MH - Adult MH - Middle Aged MH - *Suburban Population/statistics & numerical data MH - *Healthy Lifestyle MH - *Health Promotion MH - *Women's Health MH - Surveys and Questionnaires MH - *Life Style PMC - PMC13495348 OTO - NOTNLM OT - Health Promotion OT - Iran OT - Life Style OT - Suburban Population OT - Women COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Mashhad University of Medical Sciences, Mashhad, Iran, under the ethics code IR.MUMS.NURSE.REC.1404.041. All procedures were conducted in accordance with the Declaration of Helsinki and relevant ethical guidelines and regulations. Eligible women were invited to participate after receiving information about the study objectives and procedures, and written informed consent was obtained from all participants prior to data collection. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/16 06:35 MHDA- 2026/08/21 05:35 PMCR- 2026/06/15 CRDT- 2026/06/16 00:38 PHST- 2025/09/07 00:00 [received] PHST- 2026/06/06 00:00 [accepted] PHST- 2026/08/21 05:35 [medline] PHST- 2026/06/16 06:35 [pubmed] PHST- 2026/06/16 00:38 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.1186/s12905-026-04605-w [pii] AID - 4605 [pii] AID - 10.1186/s12905-026-04605-w [doi] PST - epublish SO - BMC Womens Health. 2026 Jun 15;26(1):423. doi: 10.1186/s12905-026-04605-w. PMID- 42298474 OWN - NLM STAT- Publisher LR - 20260616 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) DP - 2026 Jun 15 TI - First trimester, one-tube screening for pregnancy complications via placental biomarkers. LID - 10.1186/s12884-026-09417-2 [doi] AB - BACKGROUND: Early pregnancy screening to identify high-risk women for targeted prevention is effective for reducing pregnancy complications. Placental biomarkers, including PlGF and PAPP-A, are linked to adverse outcomes, yet their combined predictive value for pregnancy complications remains unclear. Here, a retrospective cohort study was conducted to assess first-trimester prediction models incorporating PlGF, PAPP-A, and maternal factors for major obstetric complications. METHODS: This was a retrospective cohort study using data that were prospectively collected during first-trimester screening. A cohort study was conducted at the International Peace Maternity and Child Health Hospital of China Welfare Institution (Shanghai, China) from December 2021 to October 2022. A total of 4046 participants were recruited during the first-trimester screening, excluding those with miscarriages and those without delivery data. In our routine screening, all pregnant women were tested for placental growth factor (PlGF) and pregnancy-associated plasma protein A (PAPP-A). The mean arterial pressure (MAP) and uterine artery pulsatility index (UTPI) were also measured in accordance with the Fetal Medicine Foundation guidelines, along with maternal characteristics and medical history collected via face-to-face interviews. Multivariable logistic regression was used for model development. Model performance was evaluated by the area under the receiver operating characteristic curve (AUC). RESULTS: Among 4046 initially recruited participants, data from 3910 participants regarding fetal growth restriction (FGR), gestational diabetes mellitus (GDM), placenta previa and preterm birth (PTB) were analyzed. For the PE analysis, a subgroup of 1,588 women with available UTPI measurements was evaluated. The best models for predicting FGR were the indicator height, PAPP-A levels, and PlGF levels, with an AUC of 0.742 (95% CI: 0.633-0.851). Regarding GDM prediction, the model including BMI and PAPP-A levels had the best AUC (0.667, 95% CI: 0.622-0.713). With respect to placenta previa prediction, the model including age and PlGF levels had the best AUC (0.765, 95% CI: 0.588-0.941). For PTB, indicators such as the PlGF multiples of the median (MoM), PAPP-A, type I diabetes and systemic lupus erythematosus had the best performance, with an AUC of 0.665 (95% CI: 0.553-0.776). For PE screening using the Fetal Medicine Foundation (FMF) competing-risk model (PAPP-A, PIGF, MAP, and UTPI), the model achieved an AUC of 0.847 for preterm PE (< 37 weeks), with a detection rate of 50.00%, and an AUC of 0.777 for term PE (>/= 37 weeks), with a detection rate of 95.12% at the recommended risk cutoff of 1 in 100. CONCLUSION: First-trimester screening using PlGF, PAPP-A, and maternal factors shows preliminary associations with common obstetric complications, suggesting the potential utility of these biomarkers in early risk stratification, providing a proof-of-concept tool for early risk stratification and improved management of high-risk pregnancies to reduce maternal and fetal morbidity. However, these models require validation in larger, more diverse populations before clinical consideration. CI - (c) 2026. The Author(s). FAU - Hua, Renyi AU - Hua R AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Li, Shuyuan AU - Li S AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Han, Xu AU - Han X AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Tang, Ziyuan AU - Tang Z AD - Revvity, Ltd., Women and Children Diagnosis, Shanghai, China. FAU - Ye, Baoying AU - Ye B AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Tan, Yuru AU - Tan Y AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Wang, Shan AU - Wang S AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Sun, Jinling AU - Sun J AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Cheng, Weiwei AU - Cheng W AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. wwcheng29@163.com. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. wwcheng29@163.com. FAU - Wang, Yanlin AU - Wang Y AD - International Peace Maternity and Child Health Hospital of China Welfare Institution (IPMCH), 910 Heng Shan Road, Shanghai, 200030, China. wyanlin@163.com. AD - School of Medicine, Shanghai Jiao Tong University, Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. wyanlin@163.com. LA - eng PT - Journal Article DEP - 20260615 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM OTO - NOTNLM OT - Fetal growth restriction OT - First trimester OT - Placenta previa OT - Placental biomarkers OT - Pre-eclampsia OT - Pregnancy OT - Preterm birth COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Review Board of the International Peace Maternity and Child Health Hospital Affiliated with the Shanghai JiaoTong University School of Medicine (Approval No. GKLW2019-20).Written informed consent was obtained from all participants prior to enrollment. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/16 06:35 MHDA- 2026/06/16 06:35 CRDT- 2026/06/16 00:37 PHST- 2025/02/13 00:00 [received] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/06/16 06:35 [medline] PHST- 2026/06/16 06:35 [pubmed] PHST- 2026/06/16 00:37 [entrez] AID - 10.1186/s12884-026-09417-2 [pii] AID - 10.1186/s12884-026-09417-2 [doi] PST - aheadofprint SO - BMC Pregnancy Childbirth. 2026 Jun 15. doi: 10.1186/s12884-026-09417-2. PMID- 42298466 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260828 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jun 15 TI - Impact of early postoperative enteral nutrition initiation timing on infection rate and nutritional status in children with congenital heart disease. LID - 10.1186/s12887-026-06975-4 [doi] LID - 784 AB - BACKGROUND: The optimal timing for initiating enteral nutrition after congenital heart disease surgery remains controversial. This study aimed to evaluate the impact of early versus delayed enteral nutrition initiation on postoperative infection rate and nutritional status in pediatric congenital heart disease patients. METHODS: A retrospective cohort study was conducted on 246 children (aged 1 month to 3 years) who underwent congenital heart disease surgery between January 2021 and December 2023. Patients were divided into early enteral nutrition group (enteral nutrition initiated 24 h postoperatively, n = 118). Primary outcomes included postoperative infection rate and nutritional parameters. Secondary outcomes included ICU length of stay, hospital length of stay, and mechanical ventilation duration. RESULTS: The early enteral nutrition group demonstrated significantly lower nosocomial infection rate (14.84% vs. 27.12%, P = 0.016) and surgical site infection rate (3.91% vs. 10.17%, P = 0.047). Postoperative day 7 serum albumin (35.62 +/- 4.18 vs. 32.47 +/- 5.23 g/L, P < 0.001) and prealbumin levels (168.35 +/- 42.67 vs. 142.58 +/- 38.94 mg/L, P < 0.001) were significantly higher in the early enteral nutrition group. The early enteral nutrition group also showed shorter ICU stay (5.38 +/- 2.14 vs. 7.25 +/- 3.42 days, P < 0.001) and hospital stay (12.45 +/- 4.36 vs. 16.82 +/- 5.78 days, P < 0.001). Multivariate logistic regression identified delayed enteral nutrition initiation as an independent risk factor for nosocomial infection (OR = 2.18, 95% CI: 1.12-4.24, P = 0.022). CONCLUSIONS: In this retrospective cohort study, early enteral nutrition initiation within 24 h after congenital heart disease surgery was associated with reduced infection rates, improved nutritional status, and shorter hospital stay in pediatric patients, predominantly those undergoing repair of septal defects. These observations suggest a potential benefit of early enteral nutrition in selected pediatric cardiac surgery patients; however, prospective validation is warranted before broad implementation, given the inherent limitations of the retrospective design and the predominantly lower-complexity patient population studied. CI - (c) 2026. The Author(s). FAU - Ye, Li AU - Ye L AD - Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China. xiaoyeer2025@163.com. FAU - Chen, Maoting AU - Chen M AD - Department of Nursing, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China. FAU - Wei, Qianling AU - Wei Q AD - Department of Nursing, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China. FAU - Wang, Yue AU - Wang Y AD - Department of Nursing, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, China. LA - eng PT - Journal Article DEP - 20260615 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Heart Defects, Congenital/surgery MH - Retrospective Studies MH - Infant MH - *Enteral Nutrition/methods MH - *Nutritional Status MH - Female MH - Child, Preschool MH - Length of Stay/statistics & numerical data MH - Male MH - Time Factors MH - *Postoperative Care/methods MH - *Cross Infection/epidemiology/prevention & control MH - *Surgical Wound Infection/epidemiology/prevention & control MH - *Postoperative Complications/prevention & control/epidemiology MH - Respiration, Artificial/statistics & numerical data MH - Cardiac Surgical Procedures PMC - PMC13508520 OTO - NOTNLM OT - Congenital heart disease OT - Enteral nutrition OT - Infection OT - Nutritional status OT - Pediatric cardiac surgery COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Institutional Review Board of West China Hospital of Sichuan University (approval number: 2025PS1899K). Given the retrospective nature of this study, the requirement for informed consent was waived by the Institutional Review Board of West China Hospital of Sichuan University in accordance with the national regulations for medical research involving human subjects. All study participants were minors (under the age of 16 years), and although individual informed consent was waived for this retrospective analysis, all included patients' parents or legal guardians had provided written informed consent for the original medical procedures and the use of anonymized medical data for research purposes at the time of hospital admission, as per institutional policy. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/16 06:35 MHDA- 2026/08/26 05:36 PMCR- 2026/06/15 CRDT- 2026/06/16 00:36 PHST- 2026/01/22 00:00 [received] PHST- 2026/05/05 00:00 [accepted] PHST- 2026/08/26 05:36 [medline] PHST- 2026/06/16 06:35 [pubmed] PHST- 2026/06/16 00:36 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.1186/s12887-026-06975-4 [pii] AID - 6975 [pii] AID - 10.1186/s12887-026-06975-4 [doi] PST - epublish SO - BMC Pediatr. 2026 Jun 15;26(1):784. doi: 10.1186/s12887-026-06975-4. PMID- 42298014 OWN - NLM STAT- Publisher LR - 20260615 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Jun 15 TI - Nutritional screening predicts prolonged stay in LMIC pediatric oncology settings: SCAN validation in Brazilian children. LID - 10.1038/s41390-026-05200-3 [doi] AB - BACKGROUND: Malnutrition affects 50-90% of children with cancer in low- and middle-income countries (LMICs) and worsens clinical outcomes. The Nutrition Screening Tool for Childhood Cancer (SCAN) is cancer-specific but has not been validated in Brazilian Portuguese. We aimed to evaluate the diagnostic accuracy of the Brazilian Portuguese SCAN (SCAN pt-BR) against STRONGkids and to examine its association with prolonged hospitalization and ICU admission. METHODS: Prospective diagnostic-accuracy study at a tertiary pediatric oncology center in Brazil (February-December 2021). Consecutive inpatients aged 1-18 years with expected stay >/=48 h were screened within 24-48 h of admission by pediatric dietitians using SCAN pt-BR and STRONGkids. RESULTS: Of 262 children (median age 8.8 years, 52.7% male, 41.2% hematologic malignancies), 70.2% were classified as at risk by SCAN pt-BR. Against STRONGkids >/=4, SCAN showed sensitivity 94.6%, specificity 43.2%, and ROC-AUC 0.863. SCAN risk independently predicted prolonged stay (adjusted OR 2.33, 95% CI 1.29-4.30, p = 0.006) but not ICU admission (adjusted OR 0.96, p = 0.899). CONCLUSION: SCAN pt-BR showed adequate screening performance and independently predicted prolonged hospitalization in Brazilian children with cancer. These results support its use for admission nutritional triage in LMIC pediatric oncology settings. IMPACT: SCAN identified 70.2% of children as at nutritional risk and predicted prolonged hospitalization (adjusted OR 2.33, 95% CI 1.29-4.30) independently of age, tumor group, and STRONGkids classification. Against STRONGkids high-risk classification, SCAN pt-BR showed high sensitivity (94.6%), high negative predictive value (93.6%), and ROC-AUC of 0.863. Gastrointestinal symptoms, poor oral intake, and recent weight loss were the most frequently endorsed symptom-related items that children classified as at nutritional risk, suggesting that SCAN detects acute nutritional deterioration rather than static disease characteristics. Routine application at admission could direct early dietetic referral to children most likely to require prolonged inpatient care. CI - (c) 2026. The Author(s). FAU - Duarte, Mariana Murra AU - Duarte MM AD - Department of Clinical Nutrition, Children's Cancer Hospital, Barretos Cancer Hospital, Barretos, SP, Brazil. FAU - da Silva, Marielle Ferreira AU - da Silva MF AD - Department of Clinical Nutrition, Children's Cancer Hospital, Barretos Cancer Hospital, Barretos, SP, Brazil. FAU - Alexandre, Maynara Cristina AU - Alexandre MC AD - Department of Clinical Nutrition, Children's Cancer Hospital, Barretos Cancer Hospital, Barretos, SP, Brazil. FAU - Fermino, Marise Lopes AU - Fermino ML AD - Barretos Medical School, Faculdade de Ciencias da Saude "Dr Paulo Prata" (FACISB), Barretos, SP, Brazil. FAU - do Nascimento, Ana Laura Balduino AU - do Nascimento ALB AD - Barretos Medical School, Faculdade de Ciencias da Saude "Dr Paulo Prata" (FACISB), Barretos, SP, Brazil. AD - "Innovation in Healthcare" Post-graduation Program, Barretos Cancer Hospital, Barretos, SP, Brazil. FAU - de Oliveira, Wilson Elias Jr AU - de Oliveira WE Jr AUID- ORCID: 0000-0001-9812-6282 AD - "Innovation in Healthcare" Post-graduation Program, Barretos Cancer Hospital, Barretos, SP, Brazil. woliveirajr.cipe@gmail.com. AD - Department of Pediatric Surgery, Children's Cancer Hospital, Barretos Cancer Hospital, Barretos, SP, Brazil. woliveirajr.cipe@gmail.com. LA - eng PT - Journal Article DEP - 20260615 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Consent statement: This study was conducted in accordance with the Declaration of Helsinki and Brazilian national research ethics guidelines. The protocol was approved by the Research Ethics Committee of the Hospital de Cancer de Barretos (REB #3.827.548/2019). Written informed consent was obtained from all parents or legal guardians before enrollment. EDAT- 2026/06/16 00:33 MHDA- 2026/06/16 00:33 CRDT- 2026/06/15 23:37 PHST- 2026/02/11 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/05/12 00:00 [revised] PHST- 2026/06/16 00:33 [medline] PHST- 2026/06/16 00:33 [pubmed] PHST- 2026/06/15 23:37 [entrez] AID - 10.1038/s41390-026-05200-3 [pii] AID - 10.1038/s41390-026-05200-3 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Jun 15. doi: 10.1038/s41390-026-05200-3. PMID- 42298003 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20261023 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 15 TI - Dietary patterns are associated with premenstrual symptoms: a cross-sectional study among women from Central Europe. LID - 10.1038/s41598-026-58236-0 [doi] LID - 27317 AB - To date, only a few studies have examined the relationship between dietary patterns and premenstrual syndrome (PMS), and these have been limited to Asian populations with inconclusive results, while studies in European populations are lacking. Therefore, this study aimed to examine the associations between dietary patterns and the severity of PMS in young women from a European population. This cross-sectional study included 609 women aged 18-35 years. Premenstrual symptoms and their severity were assessed using the validated Premenstrual Symptoms Screening Tool, dietary intake data were collected using a semiquantitative food frequency questionnaire, and dietary patterns were determined via K-means clustering of 13 food groups. Three dietary patterns (DPs) were identified: Healthy-DP, Western-DP, and Low-food-DP (characterized by low consumption of all food groups). In the multivariable-adjusted logistic regression model, compared with the Healthy-DP, women adhering to the Western-DP had significantly higher odds of being classified into the Severe-PMS group (OR:2.35, 95%CI:1.02-5.44). Similarly, those following the Low-food-DP had higher odds of both Moderate-PMS (OR:2.92, 95%CI:1.09-7.84) and Severe-PMS (OR:3.01, 95% CI:1.14-7.92). These findings highlight potential associations between dietary patterns and PMS severity; however, due to the cross-sectional design of the study, no causal conclusions can be drawn. CI - (c) 2026. The Author(s). FAU - Granda, Dominika AU - Granda D AD - Department of Nutrition Physiology, Institute of Sport, National Research Institute, Trylogii 2/16, Warsaw, 01-982, Poland. dominika.granda@insp.pl. AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Nowoursynowska 166, Warsaw, 02-787, Poland. dominika.granda@insp.pl. FAU - Szmidt, Maria Karolina AU - Szmidt MK AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Nowoursynowska 166, Warsaw, 02-787, Poland. maria_szmidt@sggw.edu.pl. FAU - Jarmuzek-Orska, Patrycja AU - Jarmuzek-Orska P AD - Department of Gynecology and Obstetrics with Gynecologic Oncology, Ludwik Rydygier Memorial Specialized Hospital, Zlotej Jesieni 1, Cracow, 31-826, Poland. FAU - Kaluza, Joanna AU - Kaluza J AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Nowoursynowska 166, Warsaw, 02-787, Poland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260615 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - *Premenstrual Syndrome/epidemiology/etiology MH - Cross-Sectional Studies MH - Adult MH - Young Adult MH - Adolescent MH - *Diet/adverse effects MH - Europe/epidemiology MH - *Feeding Behavior MH - Surveys and Questionnaires PMC - PMC13530195 OTO - NOTNLM OT - Cluster analysis OT - Diet OT - Dietary patterns OT - Nutrition OT - Premenstrual syndrome OT - Premenstrual syndrome screening tool COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/06/16 00:33 MHDA- 2026/09/01 05:41 PMCR- 2026/06/15 CRDT- 2026/06/15 23:37 PHST- 2025/10/23 00:00 [received] PHST- 2026/06/12 00:00 [accepted] PHST- 2026/09/01 05:41 [medline] PHST- 2026/06/16 00:33 [pubmed] PHST- 2026/06/15 23:37 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.1038/s41598-026-58236-0 [pii] AID - 58236 [pii] AID - 10.1038/s41598-026-58236-0 [doi] PST - epublish SO - Sci Rep. 2026 Jun 15;16(1):27317. doi: 10.1038/s41598-026-58236-0. PMID- 42297455 OWN - NLM STAT- MEDLINE DCOM- 20260615 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 6 DP - 2026 Jun 15 TI - Tuberculosis death prediction calculator for prospective use at diagnosis in resource-constrained programme settings: a statewide cohort study. PG - e116110 LID - 10.1136/bmjopen-2025-116110 [doi] LID - e116110 AB - OBJECTIVES: To develop predictive models for early and overall tuberculosis (TB) deaths for prospective use at TB diagnosis in resource-constrained TB programme settings. DESIGN: Statewide cohort study using routinely captured secondary data. SETTING: With the majority of TB deaths being early (within 2 months), India's TB programme's information management system (Ni-kshay)-dependent death prediction models (using age, gender, TB site, previous treatment, microbiological confirmation, HIV, diabetes and bank account availability) are not feasible for prospective use, as few variables are captured at diagnosis. Utilising routinely captured triage variables for severe illness at diagnosis (body mass index, pedal oedema, respiratory rate, oxygen saturation and ability to stand without support) from an ongoing statewide and state-specific differentiated TB care initiative to reduce TB deaths in Tamil Nadu state (southern India, 80 million population with 0.1 million annual notifications), robust models for prospective use were developed. PARTICIPANTS: Adults (aged >/=15 years) with TB (not known to be drug-resistant at diagnosis) that were notified from public facilities of Tamil Nadu from July 2022 to June 2023. OUTCOME MEASURES: Early and overall (within 12 months of notification) TB deaths. Area under the receiver operating characteristic curve (AUC) was used to assess accuracy of models built using modified Poisson regression. RESULTS: Among 55 971 adults, the overall death rate was 7.4%, and 67.9% of the deaths were early. In predicting overall deaths, accuracy of the model using all Ni-kshay variables (AUC 0.716 (95% CI 0.707 to 0.725)) was as good as the model using triage variables for severe illness only (AUC 0.701 (95% CI 0.691 to 0.711)). To the latter, adding potentially capturable Ni-kshay variables at diagnosis (age, gender, TB site, previous treatment and microbiological confirmation) significantly improved model accuracy (AUC 0.754 (95% CI 0.745 to 0.763)). Further addition of remaining Ni-kshay variables did not improve accuracy significantly. Death prediction equations were generated for these models. CONCLUSION: Simple and easily measurable triage variables for severe illness should be routinely captured at TB diagnosis. A death prediction calculator (http://44.208.93.99/) based on these variables (specifically triage variables for severe illness combined with age, gender, TB site, previous treatment and microbiological confirmation) may be used by Indian states and high TB burden countries seeking scalable, data-driven interventions to reduce TB deaths. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Shanmugasundaram, Suseendar AU - Shanmugasundaram S AD - Health Systems Research, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Shewade, Hemant Deepak AU - Shewade HD AUID- ORCID: 0000-0002-8242-1911 AD - Health Systems Research, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India hemantjipmer@gmail.com. FAU - Srinivasan, Ramalingam AU - Srinivasan R AD - Infectious Disease Epidemiology, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Frederick, Asha AU - Frederick A AD - State TB Office, Government of Tamil Nadu, Chennai, India. FAU - Sabarinathan, Ramasamy AU - Sabarinathan R AD - Computing and Information Sciences, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Harish, Premkumar AU - Harish P AD - ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Balu, Deepan AU - Balu D AD - S.A. Engineering College, Chennai, Chennai, India. FAU - Melfha, Jeen M AU - Melfha JM AD - Health Systems Research, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Gayathri, Kumari AU - Gayathri K AD - School of Public Health, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Vijayaprabha, Radhakrishnan AU - Vijayaprabha R AD - Health Systems Research, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Jeyakumar, Annadurai AU - Jeyakumar A AD - School of Public Health, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Kabir, Dilsadh AU - Kabir D AD - Health Systems Research, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Eraivan, Meikappan AU - Eraivan M AD - State TB Office, Government of Tamil Nadu, Chennai, India. FAU - Bhatnagar, Tarun AU - Bhatnagar T AUID- ORCID: 0000-0002-5603-1418 AD - School of Public Health, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. FAU - Murhekar, Manoj V AU - Murhekar MV AUID- ORCID: 0000-0002-1720-7628 AD - Infectious Disease Epidemiology, ICMR National Institute of Epidemiology (ICMR-NIE), Chennai, India. LA - eng PT - Journal Article DEP - 20260615 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - India/epidemiology MH - *Tuberculosis/mortality/diagnosis MH - Adult MH - Male MH - Resource-Limited Settings MH - Female MH - Prospective Studies MH - Middle Aged MH - Young Adult MH - Triage MH - Adolescent MH - Cohort Studies MH - ROC Curve PMC - PMC13319640 OTO - NOTNLM OT - Differentiated TB care OT - Operational Research OT - Predictive models OT - Risk stratification OT - TB mortality OT - Triaging for severe illness COIS- Competing interests: None. EDAT- 2026/06/16 00:33 MHDA- 2026/06/16 00:34 PMCR- 2026/06/15 CRDT- 2026/06/15 20:53 PHST- 2026/06/16 00:34 [medline] PHST- 2026/06/16 00:33 [pubmed] PHST- 2026/06/15 20:53 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - bmjopen-2025-116110 [pii] AID - 10.1136/bmjopen-2025-116110 [doi] PST - epublish SO - BMJ Open. 2026 Jun 15;16(6):e116110. doi: 10.1136/bmjopen-2025-116110. PMID- 42297336 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260915 IS - 1097-6833 (Electronic) IS - 0022-3476 (Linking) VI - 297 DP - 2026 Oct TI - Ambulatory Blood Pressure Thresholds and Left Ventricular Hypertrophy in Children Aged 6-12 Years: A Pediatric Nephrology Research Consortium Study. PG - 115194 LID - S0022-3476(26)00222-2 [pii] LID - 10.1016/j.jpeds.2026.115194 [doi] AB - OBJECTIVE: To evaluate the diagnostic performance of ambulatory blood pressure monitoring (ABPM) thresholds for predicting left ventricular hypertrophy (LVH) in children aged 6-12 years. STUDY DESIGN: A retrospective, multicenter study was conducted across 11 Pediatric Nephrology Research Consortium sites and included children aged 6-12 years who underwent ABPM and 2-dimensional echocardiography for diagnostic assessment of elevated BP. The diagnostic accuracy of fixed ABPM thresholds and the current 95th percentile for sex and height were assessed using area under the receiver operating characteristic, sensitivity, specificity, and Youden index. Multivariable logistic regression models, adjusted for age, sex, and body mass index z-score, were used to evaluate associations of ABPM thresholds with LVH. RESULTS: Among 279 children, hypertension was present in 51% and LVH in approximately 20%. Across all systolic and diastolic ABPM thresholds tested, area under the receiver operating characteristic values ranged from 0.5 to 0.6, indicating poor discriminatory performance, including analyses restricted to children without chronic kidney disease or obesity. Although daytime and 24-hour BP thresholds were not significantly associated with LVH, a night-time systolic BP of >/=110 mm Hg and a night-time diastolic BP of >/=70 mm Hg both increased the odds of LVH by approximately 2-fold (OR for night-time SBP, 1.93; 95% CI, 1.07-3.50; P = .03; and OR for night-time DBP, 2.27; 95% CI, 1.08-4.76; P = .03). CONCLUSIONS: In this multicenter cohort of US children aged 6-12 years, percentile-based and fixed ABPM thresholds demonstrated limited ability to discriminate LVH. Night-time systolic and diastolic BPs showed the strongest associations with LVH, underscoring the importance of nocturnal BP assessment. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Jahan, Afsana AU - Jahan A AD - Division of Pediatric Nephrology, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY. FAU - Schuchman, Matthew AU - Schuchman M AD - Division of Pediatric Nephrology, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY. FAU - Abdullah, Mahie AU - Abdullah M AD - Division of Pediatric Nephrology, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY. FAU - McLaughlin, Meghan AU - McLaughlin M AD - Department of Pediatrics, University of Rochester Medical Center, Rochester, NY. FAU - Cadiz, Emilia Maria AU - Cadiz EM AD - Department of Pediatric Nephrology, Phoenix Children Hospital, Phoenix, AZ. FAU - Manchanda, Eshanika AU - Manchanda E AD - Department of Nephrology, Children's Mercy Hospital, University of Missouri School of Medicine, Kansas City, MO. FAU - Chishti, Aftab AU - Chishti A AD - Division of Pediatric Nephrology, Golisano Children's at the University of Kentucky, Lexington, KY. FAU - Murphy, Maggie AU - Murphy M AD - Division of Pediatric Nephrology, Golisano Children's at the University of Kentucky, Lexington, KY. FAU - Twichell, Sarah AU - Twichell S AD - Division pf Pediatric Nephrology, Larner College of Medicine, University of Vermont, Burlington, VT. FAU - Mazo, Alexandra AU - Mazo A AD - Pediatric Nephrology Division, Maria Fareri Children's Hospital, Westchester Medical Center, Boston Children's Health Physicians, New York Medical College, New York, NY; Division of Pediatric Nephrology, Loma Linda University Children's Hospital, Loma Linda, CA. FAU - Samsonov, Dmitry AU - Samsonov D AD - Pediatric Nephrology Division, Maria Fareri Children's Hospital, Westchester Medical Center, Boston Children's Health Physicians, New York Medical College, New York, NY. FAU - Maniar, Aesha AU - Maniar A AD - Division of Pediatric Nephrology, Atrium Health Levine Children's Specialty Center, a Facility of Carolinas Medical Center, Wake Forest, NC. FAU - Kim, Hannah AU - Kim H AD - Division of Pediatric Nephrology, Weill Cornell Medicine, New York, NY. FAU - Lomanta, Francis AU - Lomanta F AD - Division of Pediatric Nephrology & Hypertension, University of Utah, Salt Lake City, UT. FAU - Patibandla, Ashok Chakravarthy AU - Patibandla AC AD - Division of Pediatric Nephrology & Hypertension, University of Utah, Salt Lake City, UT. FAU - Frank, Rachel AU - Frank R AD - Division of Pediatric Nephrology, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY. FAU - Srivastava, Tarak AU - Srivastava T AD - Department of Nephrology, Children's Mercy Hospital, University of Missouri School of Medicine, Kansas City, MO. FAU - Yamaguchi, Ikuyo AU - Yamaguchi I AD - Division of Pediatric Nephrology & Hypertension, University of Utah, Salt Lake City, UT. FAU - Sethna, Christine AU - Sethna C AD - Division of Pediatric Nephrology, Northwell Health, Cohen Children's Medical Center, New Hyde Park, NY. Electronic address: csethna@northwell.edu. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260615 PL - United States TA - J Pediatr JT - The Journal of pediatrics JID - 0375410 SB - IM MH - Humans MH - Child MH - *Hypertrophy, Left Ventricular/diagnosis/physiopathology MH - Female MH - Male MH - *Blood Pressure Monitoring, Ambulatory MH - Retrospective Studies MH - *Hypertension/diagnosis/complications MH - Blood Pressure MH - ROC Curve MH - Echocardiography MH - Sensitivity and Specificity OTO - NOTNLM OT - ambulatory blood pressure monitoring OT - blood pressure thresholds OT - childhood hypertension OT - left ventricular hypertrophy COIS- Declaration of Competing Interest C.S. is funded by NIH/NHLBI1R01HL162912-01A1 and NIH/NIDDKR01DK131091. C.S. has served on the advisory board for Novo Nordisk, Otsuka, and Apellis and as a consultant to Travere Therapeutics. EDAT- 2026/06/16 00:33 MHDA- 2026/09/15 23:35 CRDT- 2026/06/15 19:35 PHST- 2026/02/04 00:00 [received] PHST- 2026/05/19 00:00 [revised] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/09/15 23:35 [medline] PHST- 2026/06/16 00:33 [pubmed] PHST- 2026/06/15 19:35 [entrez] AID - S0022-3476(26)00222-2 [pii] AID - 10.1016/j.jpeds.2026.115194 [doi] PST - ppublish SO - J Pediatr. 2026 Oct;297:115194. doi: 10.1016/j.jpeds.2026.115194. Epub 2026 Jun 15. PMID- 42297042 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20260916 IS - 1678-4782 (Electronic) IS - 0021-7557 (Print) IS - 0021-7557 (Linking) VI - 102 IP - 5 DP - 2026 Sep-Oct TI - Validity of the Khamis-Roche method, relative to bone age, in Portuguese children and adolescents from 11 to 15 years. PG - 101578 LID - S0021-7557(26)00080-X [pii] LID - 10.1016/j.jped.2026.101578 [doi] LID - 101578 AB - OBJECTIVE: to validate maturity status classification, based on %PAH, relative to SA, in a sample of Portuguese children and adolescents of both sexes. METHODS: BA was measured by the Tanner-Whitehouse-3 method, the PAH and %PAH were estimated by the Tanner-Whitehouse-3 method (BA- PAH, % BA-PAH) and the Khamis-Roche method (KR- PAH, %KR- PAH) in 371 children (171 girls). Intraclass Correlation Coefficients and Bland-Altman plots were performance between BA-PAH / BA-%PAH and KR- PAH/%KR- PAH methods. Two-way Analysis of Variance (ANOVA) was made to evaluate the effect of sex and maturity status. RESULTS: The average mean differences between BA-PAH and KR-PAH was 0.2 +/- 4.2 cm in boys and 0.6 +/- 3.1 cm in girls (p > 0.05) and between BA-% PAH and KR-% PAH was -0.1 +/- 2.1% in boys and 0.4 +/- 1.8% in girls (p > 0.05). A high interclass correlation coefficient was higher than 0.91 for BA-% PAH and KR-% PAH. Early maturity status was related to negative differences between BA- KR PAH. CONCLUSION: KR % PAH presented a good agreement and might be a valid estimate of biological maturity status in average maturing children and adolescents. CI - Copyright (c) 2026 The Authors. Published by Elsevier Espana S.L.U. All rights reserved. FAU - Fragoso, Isabel AU - Fragoso I AD - Universidade de Lisboa, Faculdade de Motricidade Humana, Laboratory of Physiology and Biochemistry of Exercise, CIPER, Lisboa, Portugal. Electronic address: ifragoso@fmh.ulisboa.pt. FAU - Albuquerque, Joao AU - Albuquerque J AD - Universidade de Lisboa, Faculdade de Ciencias, Centro de Estatistica e Aplicacoes, Lisboa, Portugal. FAU - Teles, Julia AU - Teles J AD - Universidade de Lisboa, Faculdade de Motricidade Humana, Mathematical Methods Unit, CIPER, Lisboa, Portugal. FAU - Bonito, Fabiana AU - Bonito F AD - Universidade de Lisboa, Faculdade de Motricidade Humana, Laboratory of Physiology and Biochemistry of Exercise, CIPER, Lisboa, Portugal. FAU - Massuca, Luis Miguel AU - Massuca LM AD - Universidade Lusofona de Humanidades e Tecnologias, Faculdade de Educacao Fisica e Desporto, CIEFDES, Lisboa, Portugal; Instituto Superior de Ciencias Policiais e Seguranca Interna, ICPOL, Lisboa, Portugal. FAU - Moura, Fernando Paiva AU - Moura FP AD - Universidade de Lisboa, Faculdade de Motricidade Humana, Laboratory of Physiology and Biochemistry of Exercise, CIPER, Lisboa, Portugal. FAU - Barrigas, Carlos AU - Barrigas C AD - Universidade de Lisboa, Faculdade de Motricidade Humana, Laboratory of Physiology and Biochemistry of Exercise, CIPER, Lisboa, Portugal. FAU - Flores, Luis Alberto AU - Flores LA AD - Autonomous University of Chihuahua, Faculty of Physical Culture Sciences, Chihuahua, Mexico. LA - eng PT - Journal Article PT - Validation Study DEP - 20260703 PL - Brazil TA - J Pediatr (Rio J) JT - Jornal de pediatria JID - 2985188R SB - IM MH - Humans MH - Female MH - Portugal MH - Male MH - Child MH - Adolescent MH - *Age Determination by Skeleton/methods MH - Reproducibility of Results PMC - PMC13355637 OTO - NOTNLM OT - Anthropometry OT - Biological maturation OT - Percentage of adult stature OT - Somatic maturity OT - TW3 COIS- Conflicts of interest The authors report no conflict of interest. EDAT- 2026/06/16 00:33 MHDA- 2026/09/16 23:34 PMCR- 2026/07/03 CRDT- 2026/06/15 19:21 PHST- 2026/01/13 00:00 [received] PHST- 2026/05/17 00:00 [revised] PHST- 2026/05/22 00:00 [accepted] PHST- 2026/09/16 23:34 [medline] PHST- 2026/06/16 00:33 [pubmed] PHST- 2026/06/15 19:21 [entrez] PHST- 2026/07/03 00:00 [pmc-release] AID - S0021-7557(26)00080-X [pii] AID - 101578 [pii] AID - 10.1016/j.jped.2026.101578 [doi] PST - ppublish SO - J Pediatr (Rio J). 2026 Sep-Oct;102(5):101578. doi: 10.1016/j.jped.2026.101578. Epub 2026 Jul 3. PMID- 28520347 STAT- Publisher DRDT- 20260616 CTDT- 20120308 PB - National Center for Biotechnology Information (US) DP - 2012 TI - Warfarin Therapy and VKORC1 and CYP Genotype. BTI - Medical Genetics Summaries AB - Warfarin (brand name Coumadin) is an anticoagulant (blood thinner). Warfarin acts by inhibiting the synthesis of vitamin K-dependent clotting factors II, VII, IX and X, and is used in the prevention and treatment of various thrombotic disorders (1). Warfarin is a drug with narrow therapeutic index; thus, a small change in its plasma levels can result in concentration-dependent adverse drug reactions or therapeutic failure. As such, the therapeutic dose of warfarin must be tailored for each individual based on response, which is measured by the INR (International Normalized Ratio), and the condition being treated (1). There is a wide inter-individual variability -up to twenty-fold-in the dose of warfarin required to achieve therapeutic anticoagulation, and the time it takes to reach target INR. Approximately half of this variability is caused by both clinical or lifestyle factors (for example, an individual's age, body mass index, gender, diet, smoking status, ethnicity/race, existing conditions, and concomitant medications) and by genetic variants in the VKORC1, CYP2C9 and CYP4F2 genes, and the CYP2C gene cluster rs12777823 variant (1). The VKORC1 and CYP2C9 variants are the most important known genetic determinants of warfarin dosing. Warfarin targets VKORC1, an enzyme involved in vitamin K recycling. A common VKORC1 variant, c.-1639G>A, is associated with warfarin sensitivity and lower dose requirements. The CYP2C9 enzyme metabolizes S-warfarin, the more potent stereoisomer, and CYP2C9 variants with reduced activity are also associated with lower dose requirements (2). The FDA-approved drug label for warfarin states that CYP2C9 and VKORC1 genotype information, when available, can assist in the selection of the initial and maintenance dose of warfarin. The label provides 2 sets of warfarin dosing recommendations, for when the CYP2C9 and VKORC1 genotypes are either known (Table 1) or not known (taking into account clinical factors, the initial dose of warfarin is usually 2-5 mg once daily and maintenance doses are typically 2-10 mg daily) (1). The 2017 Update of the Clinical Pharmacogenetics Implementation Consortium (CPIC) Guideline for Pharmacogenetics-Guided Warfarin Dosing provides warfarin dosing recommendations for adults and pediatric individuals. Recommendations from CPIC state that these dosing guidelines are applied after a warfarin dose has been calculated using a validated pharmacogenetic algorithm, which includes genotype information for VKORC1, c.-1639G>A and CYP2C9 (Figure 1) (2). More recently, the Dutch Pharmacogenetics Working Group (DPWG) of the Royal Dutch Association for the Advancement of Pharmacy (KNMP) has published recommendations for the initial standard dose of warfarin (3). A dose reduction is recommended for individuals who are CYP2C9 poor (PM) and intermediate metabolizers (IM) (with the exception of IM with the CYP2C9*1/*2 genotype, no dose change is required), and a dose reduction is recommended for individuals who have 2 copies of the VKORC1 c.-1639G>A variant allele (c.-1639G>A/A) (Table 2) (4, 5). In addition, genetic variation in the CYP4F2 gene and a variant near the CYP2C gene cluster, rs12777823, have been associated with warfarin dosing. The CYP4F2*3 variant is associated with a modest increase in warfarin dose requirements, notably in individuals with European or Asian ancestry who are more likely to have this variant allele than other ancestral populations. Individuals with African ancestry are more likely than other ancestral groups to have the rs12777823 A/G or A/A genotype that has been associated with decreased warfarin dose requirements. FAU - Dean, Laura AU - Dean L AD - NCBI FAU - Kane, Megan AU - Kane M AD - NCBI LA - eng PT - Review PT - Book Chapter PL - Bethesda (MD) OTO - NLM OT - Warfarin OT - warfarin therapy OT - Coumadin OT - warfarin response OT - coumadin response OT - anticoagulation OT - blood thinner OT - VKORC1 OT - CYP2C9 OT - CYP4F2 OT - INR EDAT- 2026/06/16 00:00 CRDT- 2026/06/16 00:00 AID - NBK84174 [bookaccession] PMID- 42296607 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20261006 IS - 1879-1409 (Electronic) IS - 0305-4179 (Linking) VI - 52 IP - 8 DP - 2026 Nov TI - Burning questions: ED management of pediatric burns at a non-burn health care system. PG - 108071 LID - S0305-4179(26)00223-8 [pii] LID - 10.1016/j.burns.2026.108071 [doi] AB - INTRODUCTION: American Burn Association (ABA) referral criteria help identify patients to be transferred. Limited data exist on characteristics of patients being transferred and utilization of these criteria at non-burn centers (NBC). OBJECTIVES: To describe pediatric emergency department (ED) disposition practices at a non-burn center and compare these practices to ABA referral criteria. DESIGN/METHODS: Retrospective review of electronic records of patients < 18 years old, with discharge diagnosis of burn at a non-burn healthcare system, from December 2016 to June 2022, was performed. Descriptive statistics and multivariable logistic regression was used to analyze transfer rates and determine odds ratios of different factors, comparing transferred and discharged patients. RESULTS: 1231 cases were identified with 35% transferred. Of the 65% of patients discharged, 52% met ABA referral criteria. For all visits, 64% met at least one ABA criterion, of which 47% were transferred. Infants had greatest odds of transfer (OR 9.62, 95% CI 4.6 - 20.1). Burns to high-risk anatomical zones (OR 5.89, 95% CI 4.1 - 8.4), those with > 20% total body surface area (OR 16.86, 95% CI 4.3 - 66.7) and full/partial thickness burns (OR 11.47, 95% CI 5.5 - 23.9) were also all associated with highest odds of transfer. CONCLUSION: The majority of visits met ABA criteria for transfer to a burn center; however, only about half those qualified were transferred. Some may have been appropriately discharged. Infants, large burns, burns to high-risk anatomic zones, or full/partial thickness burns were more often transferred indicating appropriate adherence to the established guideline. These data suggest that ABA criteria are very broad for pediatrics and do not have face validity for community physicians. Further work is needed to refine pediatric ABA referral criteria. CI - Copyright (c) 2026 Elsevier Ltd and International Society of Burns Injuries. All rights reserved. FAU - Nandavar, Akshay Vivek AU - Nandavar AV AD - Department of Pediatric Emergency Medicine, Corewell Health/William Beaumont University Hospital, Royal Oak, MI, USA. Electronic address: akshayvivek.nandavar@ochsner.org. FAU - Seo, David Seungwoo AU - Seo DS AD - Oakland University William Beaumont School of Medicine, Rochester, MI, USA. FAU - Swor, Robert A AU - Swor RA AD - Department of Emergency Medicine, Corewell Health/William Beaumont University Hospital, Royal Oak, MI, USA. FAU - Menoch, Margaret J A AU - Menoch MJA AD - Department of Pediatric Emergency Medicine, Corewell Health/William Beaumont University Hospital, Royal Oak, MI, USA. LA - eng PT - Journal Article DEP - 20260518 PL - Netherlands TA - Burns JT - Burns : journal of the International Society for Burn Injuries JID - 8913178 SB - IM MH - Humans MH - *Burns/therapy/epidemiology MH - Retrospective Studies MH - Female MH - Child MH - *Emergency Service, Hospital/statistics & numerical data/organization & administration MH - Infant MH - Child, Preschool MH - Male MH - Adolescent MH - *Referral and Consultation/statistics & numerical data MH - *Patient Transfer/statistics & numerical data MH - Emergency Room Visits MH - Logistic Models MH - Body Surface Area MH - Infant, Newborn MH - Patient Discharge/statistics & numerical data MH - Odds Ratio OTO - NOTNLM OT - Burn OT - Emergency department OT - Non-burn center OT - Pediatric OT - Transfer COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/15 18:34 MHDA- 2026/09/16 23:34 CRDT- 2026/06/15 18:01 PHST- 2025/06/25 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/09/16 23:34 [medline] PHST- 2026/06/15 18:34 [pubmed] PHST- 2026/06/15 18:01 [entrez] AID - S0305-4179(26)00223-8 [pii] AID - 10.1016/j.burns.2026.108071 [doi] PST - ppublish SO - Burns. 2026 Nov;52(8):108071. doi: 10.1016/j.burns.2026.108071. Epub 2026 May 18. PMID- 42296558 OWN - NLM STAT- MEDLINE DCOM- 20260615 LR - 20260922 IS - 2291-5222 (Electronic) IS - 2291-5222 (Linking) VI - 14 DP - 2026 Jun 15 TI - A Pilot mHealth Text Messaging Program Targeting Parents During the First 2000 Days: Nonrandomized Repeat Cross-Sectional Analysis to Evaluate Feasibility, Engagement, Acceptability, and Potential Effectiveness. PG - e83162 LID - 10.2196/83162 [doi] LID - e83162 AB - BACKGROUND: The first 2000 days can profoundly influence long-term health. Healthy Beginnings for Hunter New England Kids (HB4HNEKids) is an SMS text messaging program delivered alongside routine Child and Family Health Nursing (CFHN) care, which provides families with evidence-based, age- and stage-related preventive health information across the first 2000 days. OBJECTIVE: This pilot study aimed to explore the feasibility, engagement, and acceptability of the HB4HNEKids program. It also aimed to explore the potential effectiveness of the program at 6 and/or 12 months post partum on outcomes including breastfeeding, child diet, child movement, and parental mental well-being. METHODS: During the pilot phase (October 2021 to July 2024), project records were used to assess the number of families enrolled, number of SMS text messages sent (feasibility), and the number of opt outs (engagement). Repeat cross-sectional surveys were conducted at 5-7 months post partum and again at 12-14 months post partum using validated survey instruments. Using convenience sampling methods, survey participants consisted of birthing parents who had received HB4HNEKids and a concurrent nonrandomized comparison group that did not receive the program. Surveys assessed parental self-reported engagement with the messages, program acceptability, breastfeeding status, child diet, child movement, and parental mental well-being. Mixed linear regression analyses were conducted to calculate mean differences and odds ratios. RESULTS: During the pilot phase, HB4HNEKids was delivered to 6243 families (73.4% of families contacted by CFHN). A total of 383 birthing parents completed the survey at 6 months (99/383, 26% receiving HB4HNEKids), and 283 completed the survey at 12 months (104/283, 37% receiving HB4HNEKids). Of the survey participants who received HB4HNEKids (n=200), between 76% and 83% reported that they always or very often read the SMS text messages, spending on average 5-7 minutes engaged with the content. At both survey time points, more than 90% of participants receiving HB4HNEKids agreed that the program was acceptable. Child daily intake of vegetables was significantly higher in the HB4HNEKids group (adjusted mean difference 0.23, 95% CI 0.07-0.40; P=.006) than in the comparison group at 12 months. Parents receiving HB4HNEKids also reported significantly better mental well-being scores (P=.005). While HB4HNEKids participants reported breastfeeding rates 5 percentage points greater than comparison participants at 6 and 12 months, this result was not statistically significant. There were no statistically significant differences between HB4HNEKids, and comparison participant responses related to child movement behaviors. CONCLUSIONS: The HB4HNEKids SMS text messaging program is feasible to deliver at scale alongside routine CFHN care and is highly acceptable and engaging to parents. This pragmatic evaluation of the pilot, embedded into usual care, indicates potential effectiveness of the program for improving child vegetable intakes and parental mental well-being. Further evaluation of this program using robust methodology is needed to determine the effectiveness of this innovative mHealth program across the first 2000 days. CI - (c) Jacklyn Jackson, Nayerra Hudson, Tessa Delaney, Alison L Brown, Sienna Kavalec, Jessica Pinfold, Rebecca Sewter, Hannah McCormick, Rebecca Liackman, Christophe Lecathelinais, Lynda Davies, Luke Wolfenden, Daniel Groombridge, Belinda Tully, Sinead Redman, Tauri Smart, Nafiseh Ghafournia, Paul David Craven, Rachel Sutherland. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org). FAU - Jackson, Jacklyn AU - Jackson J AUID- ORCID: 0000-0001-7633-0418 AD - School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, Australia, 61 0249246499. AD - Hunter Medical Research Institute, Newcastle, Australia. AD - Hunter New England Local Health District, New Lambton, Australia. AD - National Centre of Implementation Science, The University of Newcastle, Callaghan, Australia. FAU - Hudson, Nayerra AU - Hudson N AUID- ORCID: 0000-0002-0069-1564 AD - School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, Australia, 61 0249246499. AD - Hunter Medical Research Institute, Newcastle, Australia. AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Delaney, Tessa AU - Delaney T AUID- ORCID: 0000-0002-2756-4821 AD - School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, Australia, 61 0249246499. AD - Hunter Medical Research Institute, Newcastle, Australia. AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Brown, Alison L AU - Brown AL AUID- ORCID: 0000-0002-4233-7467 AD - School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, Australia, 61 0249246499. AD - Hunter Medical Research Institute, Newcastle, Australia. AD - Hunter New England Local Health District, New Lambton, Australia. AD - National Centre of Implementation Science, The University of Newcastle, Callaghan, Australia. FAU - Kavalec, Sienna AU - Kavalec S AUID- ORCID: 0009-0003-7605-4646 AD - School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, Australia, 61 0249246499. AD - National Centre of Implementation Science, The University of Newcastle, Callaghan, Australia. FAU - Pinfold, Jessica AU - Pinfold J AUID- ORCID: 0009-0006-4308-9430 AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Sewter, Rebecca AU - Sewter R AUID- ORCID: 0009-0008-4388-1334 AD - Hunter New England Local Health District, New Lambton, Australia. FAU - McCormick, Hannah AU - McCormick H AUID- ORCID: 0009-0009-2157-244X AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Liackman, Rebecca AU - Liackman R AUID- ORCID: 0009-0008-0958-4598 AD - School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, Australia, 61 0249246499. AD - Hunter Medical Research Institute, Newcastle, Australia. AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Lecathelinais, Christophe AU - Lecathelinais C AUID- ORCID: 0000-0002-8931-473X AD - School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, Australia, 61 0249246499. AD - Hunter Medical Research Institute, Newcastle, Australia. AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Davies, Lynda AU - Davies L AUID- ORCID: 0000-0002-2747-5589 AD - Hunter Medical Research Institute, Newcastle, Australia. AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Wolfenden, Luke AU - Wolfenden L AUID- ORCID: 0000-0002-6178-3868 AD - School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, Australia, 61 0249246499. AD - Hunter Medical Research Institute, Newcastle, Australia. AD - Hunter New England Local Health District, New Lambton, Australia. AD - National Centre of Implementation Science, The University of Newcastle, Callaghan, Australia. FAU - Groombridge, Daniel AU - Groombridge D AUID- ORCID: 0000-0002-8393-6431 AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Tully, Belinda AU - Tully B AUID- ORCID: 0009-0006-4626-7466 AD - Hunter New England Local Health District, New Lambton, Australia. AD - Armajun Health Service Aboriginal Corporation, Inverell, Australia. FAU - Redman, Sinead AU - Redman S AUID- ORCID: 0009-0006-8960-5568 AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Smart, Tauri AU - Smart T AUID- ORCID: 0009-0008-9204-1788 AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Ghafournia, Nafiseh AU - Ghafournia N AUID- ORCID: 0000-0002-7688-5138 AD - Hunter Medical Research Institute, Newcastle, Australia. AD - School of Humanities, Creative Industries and Social Sciences, The University of Newcastle, Callaghan, Australia. AD - Western Sydney Local Health District, Paramatta, Australia. FAU - Craven, Paul David AU - Craven PD AUID- ORCID: 0009-0005-5343-0893 AD - Hunter New England Local Health District, New Lambton, Australia. FAU - Sutherland, Rachel AU - Sutherland R AUID- ORCID: 0000-0003-0470-7663 AD - School of Medicine and Public Health, The University of Newcastle, University Drive, Callaghan, 2308, Australia, 61 0249246499. AD - Hunter Medical Research Institute, Newcastle, Australia. AD - Hunter New England Local Health District, New Lambton, Australia. AD - National Centre of Implementation Science, The University of Newcastle, Callaghan, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260615 PL - Canada TA - JMIR Mhealth Uhealth JT - JMIR mHealth and uHealth JID - 101624439 SB - IM MH - Humans MH - *Text Messaging/statistics & numerical data/standards/instrumentation MH - Pilot Projects MH - Cross-Sectional Studies MH - Female MH - Male MH - *Parents/psychology MH - Feasibility Studies MH - Adult MH - Surveys and Questionnaires MH - Telemedicine/standards/statistics & numerical data MH - Program Evaluation/methods PMC - PMC13270169 OTO - NOTNLM OT - acceptability OT - child health OT - cross-sectional OT - digital health OT - feasibility OT - first 2000 days OT - mHealth OT - text message COIS- Conflicts of Interest: None declared. EDAT- 2026/06/15 18:34 MHDA- 2026/06/16 00:33 PMCR- 2026/06/15 CRDT- 2026/06/15 17:53 PHST- 2025/08/28 00:00 [received] PHST- 2026/02/05 00:00 [revised] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/06/16 00:33 [medline] PHST- 2026/06/15 18:34 [pubmed] PHST- 2026/06/15 17:53 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - v14i1e83162 [pii] AID - 83162 [pii] AID - 10.2196/83162 [doi] PST - epublish SO - JMIR Mhealth Uhealth. 2026 Jun 15;14:e83162. doi: 10.2196/83162. PMID- 42295709 OWN - NLM STAT- MEDLINE DCOM- 20260615 LR - 20260813 IS - 0971-5916 (Print) IS - 0971-5916 (Linking) VI - 163 IP - 6 DP - 2026 Jun TI - Household food insecurity in urban slums and its association with nutritional status of under-five children in Salem District, Tamil Nadu. PG - 838-846 LID - 10.25259/IJMR_2123_2025 [pii] AB - Background and objectives Household food security is defined as physical and economic access to sufficient, safe, and nutritious food for an active and healthy life. Evidence suggests that urban poor are more food insecure (51%-Delhi and 74.6%-Vellore) than rural poor. Food insecurity adversely affects under-five children's nutritional status. This study aimed to assess prevalence, determinants, and its association with child-nutrition in urban slums of Salem district, Tamil Nadu. Methods A community-based cross-sectional study was conducted among 363 randomly selected households between January to September 2023 using multi-stage random sampling. Data were collected from primary-care-givers using a validated-semi-structured-questionnaire (USAID-HFIAS) followed by measurement of daily raw food consumption and anthropometry of under-five children. Statistical analysis was performed in SPSSv16.0 using Chi-square/Fisher's test, ANOVA and regression with P<0.05 taken as significant. Results Household food insecurity prevalence was 82.1%, with 20.1% severe. Mean food consumption was significantly lower among insecure households. Determinants included age/gender of household head, single earning member, dependents, and irregular use of public distribution system. Children with normal nutrition had 2.75 [P<0.05;95% confidence interval (C.I):1.31-5.75] times odds of belonging to secure households. Interpretation and conclusions Food insecurity was closely linked to under-five malnutrition, underscoring the need for interventions addressing affordability and structural factors such as housing, healthcare access, and resource distribution. FAU - Arumugam, Daivik Padmavathi AU - Arumugam DP AD - Department of Community Medicine, Government Namakkal Medical College, Chennai, Tamil Nadu, India. FAU - Ramasamy, Umamaheswari AU - Ramasamy U AD - Institute of Community Medicine, Madras Medical College, Chennai, Tamil Nadu, India. LA - eng PT - Journal Article PL - United States TA - Indian J Med Res JT - The Indian journal of medical research JID - 0374701 SB - IM MH - Humans MH - *Food Insecurity MH - *Nutritional Status MH - Female MH - India/epidemiology MH - Poverty Areas MH - Child, Preschool MH - Male MH - Infant MH - Urban Population MH - Cross-Sectional Studies MH - Family Characteristics MH - Food Supply MH - Rural Population MH - Poverty MH - Malnutrition/epidemiology MH - Socioeconomic Factors PMC - PMC13289621 OTO - NOTNLM OT - Food insecurity OT - Nutritional status OT - Preschool OT - Socio-economic factors OT - Urban population COIS- None. EDAT- 2026/06/15 12:55 MHDA- 2026/06/15 12:56 PMCR- 2026/06/01 CRDT- 2026/06/15 11:22 PHST- 2025/08/11 00:00 [received] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/06/15 12:56 [medline] PHST- 2026/06/15 12:55 [pubmed] PHST- 2026/06/15 11:22 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - 10.25259/IJMR_2123_2025 [pii] AID - 10.25259/IJMR_2123_2025 [doi] PST - ppublish SO - Indian J Med Res. 2026 Jun;163(6):838-846. doi: 10.25259/IJMR_2123_2025. PMID- 42295494 OWN - NLM STAT- MEDLINE DCOM- 20260615 LR - 20260922 IS - 1573-2649 (Electronic) IS - 0962-9343 (Print) IS - 0962-9343 (Linking) VI - 35 IP - 8 DP - 2026 Jun 15 TI - Trends in cardiometabolic disease and health-related quality of life in the United States, 2001-2022. LID - 10.1007/s11136-026-04300-1 [doi] LID - 195 AB - PURPOSE: To examine associations between cardiometabolic conditions and health-related quality of life (HRQoL) and evaluate temporal trends in condition-associated HRQoL decrements from 2001 to 2022. METHODS: We analyzed nationally representative data from U.S. adults aged >/= 18 years in the Medical Expenditure Panel Survey (2001-2022), excluding years without BMI data collection (2017, 2019, 2021). HRQoL was measured using EQ-5D utilities mapped from SF-12 scores with a validated algorithm. For each year, survey-weighted multivariable regression models estimated associations of sociodemographic characteristics, BMI, and six cardiometabolic conditions with HRQoL. Temporal trends in condition-associated HRQoL decrements were assessed using meta-regression. To estimate recent average associations, we pooled data from 2015, 2016, 2018, and 2022. RESULTS: HRQoL improved over time, with lower values in 2001-2012 than 2013-2022 and an increase from its lowest value in 2012 (0.873) to highest in 2018 (0.888). Stroke contributed the greatest adjusted HRQoL decrement, followed by heart disease, diabetes, high blood pressure, obesity, and high cholesterol. Diabetes- and heart disease-associated decrements attenuated linearly over time (-0.0500 in 2001 to -0.0414 in 2022 and -0.0611 to -0.0487, respectively) , whereas high blood pressure-associated decrement was greatest around 2012 (-0.0361 in 2001, -0.0404 in 2012, and - 0.0313 in 2022) and obesity-associated decrement was smallest around 2012 (- 0.0311, - 0.0290, and - 0.0370). CONCLUSIONS: Changes in condition-associated HRQoL decrements over time suggest that utility values may not remain constant across calendar years. Smaller decrements for diabetes and heart disease may reflect better treatment and management, whereas the growing obesity-related decrement may indicate changes in the national severity of obesity. These patterns highlight the need for current, nationally representative utility estimates in population health research. CI - (c) 2026. The Author(s). FAU - Yang, Danwei AU - Yang D AUID- ORCID: 0000-0003-3858-4673 AD - Department of Public Health Sciences, University of Chicago, Chicago, IL, USA. FAU - Kim, David D AU - Kim DD AUID- ORCID: 0000-0002-3383-8972 AD - Department of Public Health Sciences, University of Chicago, Chicago, IL, USA. David.Kim@bsd.uchicago.edu. AD - Department of Medicine, University of Chicago, Chicago, IL, USA. David.Kim@bsd.uchicago.edu. LA - eng GR - R01 MD019094/MD/NIMHD NIH HHS/United States GR - R01MD019094/NH/NIH HHS/United States PT - Journal Article DEP - 20260615 PL - Netherlands TA - Qual Life Res JT - Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation JID - 9210257 SB - IM MH - Humans MH - *Quality of Life MH - United States/epidemiology MH - Female MH - Middle Aged MH - Adult MH - Male MH - *Cardiovascular Diseases/epidemiology MH - Aged MH - *Health Status MH - Young Adult MH - Body Mass Index MH - Adolescent MH - Obesity/epidemiology MH - Surveys and Questionnaires PMC - PMC13269321 OAB - Cardiometabolic conditions such as diabetes, heart disease, stroke, high blood pressure, obesity, and high cholesterol are common chronic diseases in the United States and can reduce health-related quality of life. However, it is unclear whether their impact on health-related quality of life has changed over time as disease management and treatment have improved. Using nationally representative survey data from U.S. adults collected between 2001 and 2022, we estimated how much each cardiometabolic condition reduced health-related quality of life and whether the condition-specific estimates have changed over time. Overall health-related quality of life improved between 2001 and 2022, with the greatest gains among older adults. Stroke had the largest negative impact on health-related quality of life, followed by heart disease, diabetes, high blood pressure, obesity, and high cholesterol. The health-related quality-of-life gap between adults with and without diabetes or heart disease has narrowed over time, a pattern consistent with improved disease management and treatment. In contrast, the quality-of-life gap associated with obesity increased in recent years, a pattern consistent with the rise in severe obesity nationally. Researchers and policymakers may use up to date quality of life estimates rather than older figures when evaluating the burden of cardiometabolic disease. Using updated disease-attributable health-related quality of life estimates would better reflect the current burden of cardiometabolic disease. OABL- eng OTO - NOTNLM OT - Cardiometabolic diseases OT - EQ-5D OT - Health-related quality of life (HRQoL) OT - Temporal trends COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: This study used de-identified, publicly available data from the Medical Expenditure Panel Survey, which is conducted by the Agency for Healthcare Research and Quality. No identifiable human subjects data were used. Consent to participate: Not applicable. Consent for publication: Not applicable. Preprint server: A previous version of this manuscript was posted on medRxiv as a preprint. The current manuscript has been revised in response to peer-review comments and differs from the posted preprint. DOI: 10.64898/2026.02.20.26346754. EDAT- 2026/06/15 12:52 MHDA- 2026/06/15 12:53 PMCR- 2026/06/15 CRDT- 2026/06/15 11:18 PHST- 2026/04/01 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/06/15 12:53 [medline] PHST- 2026/06/15 12:52 [pubmed] PHST- 2026/06/15 11:18 [entrez] PHST- 2026/06/15 00:00 [pmc-release] AID - 10.1007/s11136-026-04300-1 [pii] AID - 4300 [pii] AID - 10.1007/s11136-026-04300-1 [doi] PST - epublish SO - Qual Life Res. 2026 Jun 15;35(8):195. doi: 10.1007/s11136-026-04300-1. PMID- 42295221 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20261008 IS - 1939-134X (Electronic) IS - 1040-3590 (Linking) VI - 38 IP - 10 DP - 2026 Oct TI - Maladaptive exercise: A psychometric investigation. PG - 716-728 LID - 10.1037/pas0001479 [doi] AB - There are multiple conceptualizations of maladaptive exercise with each being assessed by different measures. This has led to challenges in integrating the literature. Better understanding of the underlying processes of maladaptive exercise is needed to better conceptualize the construct. The present study used data from two independent samples, a college student sample (n = 497), identified primarily as female (72%), male (22%), White (38%), and Black (22%), and a sample recruited for their exercise engagement (n = 500), identified primarily as female (41%), male (56%), White (57%), and Black (20%). All participants completed self-report measures, including measures of maladaptive exercise (i.e., the Exercise Dependence Scale-Revised, Exercise Addiction Inventory-3, and Compulsive Exercise Test) and assessments of focal criterion variables for the problematic behavior (i.e., impulsivity, compulsivity, and eating disorder pathology). We used exploratory factor analysis to examine the overlapping and distinct content across measures of maladaptive exercise. We then examined correlations between the focal criterion variables and the measures of maladaptive exercise and latent factors. In both samples, the exploratory factor analysis suggested a four-factor solution reflecting tolerance and structure, impairment, exercise worries, and affect regulation. Our findings highlight the overlapping and distinct qualities of the varying assessment instruments and how those qualities map onto the potential underlying processes of maladaptive exercise. Future work should continue to refine the features of a broad definition of maladaptive exercise and develop a self-report measure that integrates the content from the existing measures. (PsycInfo Database Record (c) 2026 APA, all rights reserved). FAU - Schleyer, Brooke AU - Schleyer B AUID- ORCID: 0009-0008-0375-0487 AD - Department of Psychology and Neuroscience, Temple University. FAU - Olino, Thomas M AU - Olino TM AUID- ORCID: 0000-0001-5139-8571 AD - Department of Psychology and Neuroscience, Temple University. LA - eng PT - Journal Article DEP - 20260615 PL - United States TA - Psychol Assess JT - Psychological assessment JID - 8915253 SB - IM MH - Humans MH - Female MH - Male MH - Psychometrics MH - Young Adult MH - *Exercise/psychology MH - Adult MH - Adolescent MH - Factor Analysis, Statistical MH - *Behavior, Addictive/psychology/diagnosis MH - *Feeding and Eating Disorders/psychology MH - Impulsive Behavior MH - Compulsive Exercise MH - Self Report MH - Students/psychology EDAT- 2026/06/15 12:52 MHDA- 2026/09/21 17:47 CRDT- 2026/06/15 11:03 PHST- 2026/09/21 17:47 [medline] PHST- 2026/06/15 12:52 [pubmed] PHST- 2026/06/15 11:03 [entrez] AID - 2027-83726-001 [pii] AID - 10.1037/pas0001479 [doi] PST - ppublish SO - Psychol Assess. 2026 Oct;38(10):716-728. doi: 10.1037/pas0001479. Epub 2026 Jun 15. PMID- 42294390 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 1662-5153 (Print) IS - 1662-5153 (Electronic) IS - 1662-5153 (Linking) VI - 20 DP - 2026 TI - Physical activity, sedentary behavior, and cognitive function in children and adolescents: a scoping review of dose-response relationships, screen time interactions, and public health implications. PG - 1848119 LID - 10.3389/fnbeh.2026.1848119 [doi] LID - 1848119 AB - BACKGROUND: Physical inactivity among children and adolescents has reached critical levels worldwide, with approximately 81% of school-aged youth failing to meet the World Health Organization recommendation of at least 60 min of moderate-to-vigorous physical activity per day. At the same time, screen-based sedentary behaviors have increased substantially, raising concerns about their combined impact on brain development, cognitive processes, and behavioral regulation. Although extensive research exists, evidence regarding dose-response relationships, neurobiological mechanisms, and the moderating role of screen-related behaviors remains fragmented. OBJECTIVES: This scoping review aimed to systematically map the evidence linking physical activity and sedentary behavior with cognitive outcomes in children and adolescents, examine dose-response patterns, synthesize underlying neurobiological mechanisms (including brain-derived neurotrophic factor and neuroplasticity), and evaluate the moderating influence of screen time and smartphone-related behaviors. METHODS: The review followed PRISMA-ScR guidelines and the Joanna Briggs Institute methodology. Six electronic databases (PubMed/MEDLINE, Scopus, Web of Science, SPORTDiscus, PsycINFO, and CINAHL) were searched for studies published between January 2000 and March 2026. Eligibility criteria were defined using the Population-Concept-Context framework. Two independent reviewers conducted screening, achieving strong inter-rater reliability (kappa = 0.84). RESULTS: Of 2,843 records identified, 60 studies met inclusion criteria across four thematic domains: physical activity and cognitive outcomes, dose-response parameters, neurobiological mechanisms, and screen-based sedentary behavior including nomophobia. Chronic physical activity, particularly in school-based and clinical ADHD settings, was consistently associated with executive function improvements across included systematic reviews and trials. Screen time exceeding 4 h per day was associated with anxiety, depressive symptoms, and attentional deficits in observational data. Evidence on exercise-induced BDNF upregulation, contingent on structured exposure (>/=3 sessions/week, >/=12 weeks), is restricted to five pediatric RCTs and warrants cautious interpretation. CONCLUSION: This scoping review maps consistent associations between physical activity and improved cognitive function in youth, mediated through neurobiological pathways that vary in strength across study designs and populations. Excessive screen exposure is associated with cognitive risk in observational data. Integrated public health frameworks addressing physical activity, screen time, and sleep represent a priority direction for future longitudinal research and policy development. CI - Copyright (c) 2026 Dergaa, Dhahbi, Dergaa, Razzak, Ceylan, Stefanica, Muntean and Guelmami. FAU - Dergaa, Ismail AU - Dergaa I AD - Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Manouba, Tunisia. AD - Research Unit of Physical Activity, Sport, and Health, UR18JS01, National Observatory on Sport, Tunis, Tunisia. AD - Higher Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef, Tunisia. FAU - Dhahbi, Wissem AU - Dhahbi W AD - Higher Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef, Tunisia. FAU - Dergaa, Mohamed Amine AU - Dergaa MA AD - Higher Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef, Tunisia. FAU - Razzak, Mortadha AU - Razzak M AD - Higher Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef, Tunisia. FAU - Ceylan, Halil Ibrahim AU - Ceylan HI AD - Department of Physical Education and Sports Teaching, Faculty of Sport Sciences, Ataturk University, Erzurum, Turkiye. FAU - Stefanica, Valentina AU - Stefanica V AD - Department of Physical Education and Sport, Faculty of Sciences, Physical Education and Informatics, National University of Science and Technology Politehnica Bucharest, Pitesti University Center, Pitesti, Romania. FAU - Muntean, Raul Ioan AU - Muntean RI AD - Department of Physical Education and Sport, Faculty of Law and Social Sciences, University "1 Decembrie 1918" of Alba Iulia, Alba Iulia, Romania. FAU - Guelmami, Noomen AU - Guelmami N AD - Higher Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef, Tunisia. LA - eng PT - Journal Article PT - Review DEP - 20260529 PL - Switzerland TA - Front Behav Neurosci JT - Frontiers in behavioral neuroscience JID - 101477952 PMC - PMC13260285 OTO - NOTNLM OT - BDNF OT - academic performance OT - brain development OT - children OT - cognitive function OT - dose-response OT - executive function OT - neuroplasticity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/15 12:50 MHDA- 2026/06/15 12:51 PMCR- 2026/05/29 CRDT- 2026/06/15 07:45 PHST- 2026/04/05 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/06/15 12:51 [medline] PHST- 2026/06/15 12:50 [pubmed] PHST- 2026/06/15 07:45 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - 10.3389/fnbeh.2026.1848119 [doi] PST - epublish SO - Front Behav Neurosci. 2026 May 29;20:1848119. doi: 10.3389/fnbeh.2026.1848119. eCollection 2026. PMID- 42293510 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2517-729X (Print) IS - 2517-729X (Electronic) IS - 2517-729X (Linking) VI - 39 IP - 3 DP - 2026 Jun TI - Exercise type, dose and mental health outcomes in youth: Which types and doses are sufficient? PG - e70031 LID - 10.1002/gps3.70031 [doi] LID - e70031 AB - BACKGROUND: Although experimental evidence supports links between exercise and certain mental health indicators, epidemiological research has focused primarily on the dose-response effect of a single type of exercise, overlooking potential differences across exercise types in their associations with overall and specific mental health outcomes. AIMS: To examine the associations between different types of exercise and multiple mental health outcomes, including depression, anxiety, post-traumatic stress disorder, suicidal ideation, suicide attempts and nonsuicidal self-injury, and to explore their dose-response relationships in terms of exercise frequency and duration. METHODS: Data were drawn from a large-scale, cross-sectional study of 79 011 university students in Jilin Province, China, in 2021 via an online survey. Mental health outcomes were evaluated using validated scales and diagnoses. Propensity score matching was first applied to balance covariates between exercise types. Logistic regression analysis was then used to examine the associations between exercise types and mental health outcomes. Additionally, generalised additive models were employed to explore the dose-response relationships between exercise frequency/duration and mental health outcomes, adjusting for sociodemographic factors. RESULTS: Among the 79 011 students reporting participation in physical exercise, team ball sports showed the strongest protective associations, followed by single anaerobic activities, two-player racket sports, single moderate-intensity aerobic sports and single low-intensity aerobic sports. U-shaped associations were observed between exercise frequency, duration and mental health outcomes. Exercising three to four times per week for 90-120 min was associated with a lower probability of reporting mental health problems, whereas excessive exercise was associated with poorer outcomes. CONCLUSION: Participation in different types of exercise is differentially associated with mental health outcomes, with team ball sports showing the most favourable associations. Optimal levels of exercise dosage vary between exercise types, suggesting that individuals may benefit from selecting exercise patterns that best support their mental health. CI - (c) 2026 The Author(s). General Psychiatry published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Mental Health Center. FAU - Wang, Huagen AU - Wang H AUID- ORCID: 0000-0002-1532-9365 AD - Department of Psychology, School of Humanities and Social Sciences Beijing Forestry University Beijing China. FAU - Aku, Yisheng AU - Aku Y AD - Vanke School of Public Health Tsinghua University Beijing China. AD - College of Athletic Training Chengdu Sports University Chengdu Sichuan China. FAU - Xu, Shicun AU - Xu S AD - Northeast Asian Research Center Jilin University Changchun Jilin China. AD - Department of Population, Resources and Environment, Northeast Asian Studies College Jilin University Changchun Jilin China. FAU - Ren, Zhanbing AU - Ren Z AD - College of Physical Education Shenzhen University Shenzhen Guangdong China. FAU - Zhang, Yingjie AU - Zhang Y AD - Tsinghua University Hospital Beijing China. FAU - Chen, Runsen AU - Chen R AUID- ORCID: 0000-0003-3398-5750 AD - Vanke School of Public Health Tsinghua University Beijing China. AD - Institute for Healthy China Tsinghua University Beijing China. FAU - An, Jing AU - An J AUID- ORCID: 0009-0005-6539-4981 AD - Beijing Huilongguan Hospital, Capital Medical University Beijing China. AD - Huilongguan Clinical Medical School Peking University Beijing China. AD - WHO Collaborating Center for Research and Training in Suicide Prevention Beijing China. LA - eng PT - Journal Article DEP - 20260612 PL - United States TA - Gen Psychiatr JT - General psychiatry JID - 101735271 PMC - PMC13261303 COIS- The authors declare no conflicts of interest. EDAT- 2026/06/15 12:53 MHDA- 2026/06/15 12:54 PMCR- 2026/06/12 CRDT- 2026/06/15 07:39 PHST- 2025/06/05 00:00 [received] PHST- 2026/03/25 00:00 [revised] PHST- 2026/04/15 00:00 [accepted] PHST- 2026/06/15 12:54 [medline] PHST- 2026/06/15 12:53 [pubmed] PHST- 2026/06/15 07:39 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - GPS370031 [pii] AID - 10.1002/gps3.70031 [doi] PST - ppublish SO - Gen Psychiatr. 2026 Jun;39(3):e70031. doi: 10.1002/gps3.70031. Epub 2026 Jun 12. PMID- 42293213 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Integrating health promotion into biology education: effects of classroom and extracurricular interventions in rural adolescents. PG - 1813900 LID - 10.3389/fnut.2026.1813900 [doi] LID - 1813900 AB - OBJECTIVE: Aim to explore the feasibility and preliminary impact of classroom-based and extracurricular interventions within eighth-grade biology curriculum to improve health promotion behavior (HPB) and multidimensional health of rural adolescents in China. METHODS: An exploratory study with two surveys was conducted at eighth-grade students in a Chinese rural middle school. The intervention combined theoretical classroom instruction with practical extracurricular activities, all embedded within the biology curriculum. Given the incomplete pairing of the two survey samples, the data were analyzed as independent samples. Statistical significance was assessed using the Chi-square test for categorical variables and the Mann-Whitney U test for continuous variables. RESULTS: Analyses indicated that the intervention was associated with significant positive outcomes. Compared with the first survey, the second had significantly higher overall HPB scores (p = 0.006, r = 0.155). Specifically, significant increases were observed in exercise behavior (p < 0.001, r = 0.231) and health responsibility (p = 0.004, r = 0.162). Additionally, the second survey group reported significantly better outcomes across multidimensional health, including self-reported health (p = 0.030, r = 0.121), physical health (p = 0.003, r = 0.167), and mental health (p = 0.009, r = 0.146). Subgroup analyses across both survey time points further revealed that the HPB-high group consistently scored significantly higher than the HPB-low group across all three health dimensions (all p < 0.001, r >/= 0.460). CONCLUSION: This exploratory study confirmed the feasibility of classroom-based and extracurricular intervention and its potential to improve adolescent health. The observed correlation between high HPB and better health outcomes only suggests an association and the need for targeted support. Our findings recommend a collaborative model in which educators and health professionals jointly develop and implement interventions to advance the holistic development of rural adolescents. CI - Copyright (c) 2026 Chen, Dang and Tian. FAU - Chen, Jie AU - Chen J AD - School of Marxism, Xinyang Normal University, Xinyang, Henan, China. FAU - Dang, Ruiping AU - Dang R AD - College of Life Science, Xinyang Normal University, Xinyang, Henan, China. FAU - Tian, Hua AU - Tian H AD - College of Tea and Food Science, Xinyang Normal University, Xinyang, Henan, China. LA - eng PT - Journal Article DEP - 20260528 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13253422 OTO - NOTNLM OT - biology teacher OT - health promotion behaviors OT - intervention OT - multidimensional health OT - rural school students OT - school nurses COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/15 12:53 MHDA- 2026/06/15 12:54 PMCR- 2026/05/28 CRDT- 2026/06/15 07:36 PHST- 2026/02/19 00:00 [received] PHST- 2026/05/04 00:00 [revised] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/06/15 12:54 [medline] PHST- 2026/06/15 12:53 [pubmed] PHST- 2026/06/15 07:36 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - 10.3389/fnut.2026.1813900 [doi] PST - epublish SO - Front Nutr. 2026 May 28;13:1813900. doi: 10.3389/fnut.2026.1813900. eCollection 2026. PMID- 42292924 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2377-9608 (Electronic) IS - 2377-9608 (Linking) VI - 12 DP - 2026 Jan-Dec TI - Innovations in Pediatric Nursing: Emerging Technologies Including Virtual Reality, Telehealth, Artificial Intelligence, and Digital Mental Health-A Scoping Review. PG - 23779608261433684 LID - 10.1177/23779608261433684 [doi] LID - 23779608261433684 AB - BACKGROUND: Pediatric nursing is rapidly evolving with the integration of innovative technologies aimed at improving healthcare delivery and outcomes for children. OBJECTIVES: To map the extent and characteristics of pediatric nursing literature on (1) virtual reality (VR) for procedural care, (2) telehealth models, (3) artificial intelligence (AI)-supported diagnostics, (4) technology-enabled obesity interventions, and (5) digital mental-health tools; and to identify outcomes studied, populations/settings, study designs, and research gaps. METHODS: A scoping review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines was conducted. Peer-reviewed articles published from 2010 to 2024 were retrieved from PubMed, CINAHL, Scopus, Cochrane Library, and Google Scholar. Inclusion criteria were studies involving pediatric populations and addressing one of the specified technologies or interventions. RESULTS: Twenty-five studies were included. VR was effective in reducing procedural pain and anxiety. Telehealth improved care access, especially in underserved areas. AI-supported early diagnosis of diseases such as congenital heart defects. Nursing interventions for childhood obesity were most effective when multidisciplinary and personalized. Digital tools helped pediatric patients manage mental health conditions associated with chronic illness. However, gaps exist in long-term effectiveness, scalability, and integration. CONCLUSIONS: Emerging technologies in pediatric nursing offer substantial benefits but require further validation and structured implementation. Future research should focus on standardizing protocols, assessing cost-effectiveness, and addressing equity in access. CI - (c) The Author(s) 2026. FAU - Mohamed, Shimmaa Mansour Moustafa AU - Mohamed SMM AUID- ORCID: 0000-0002-2956-610X AD - Department of Nursing, College of Applied Medical Sciences, University of Bisha, Bisha, Saudi Arabia. RINGGOLD: 488770 LA - eng PT - Journal Article PT - Review DEP - 20260612 PL - United States TA - SAGE Open Nurs JT - SAGE open nursing JID - 101724853 PMC - PMC13263502 OTO - NOTNLM OT - children OT - new graduate/graduate nurse OT - pediatrics OT - scoping review COIS- The author declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/06/15 12:50 MHDA- 2026/06/15 12:51 PMCR- 2026/06/12 CRDT- 2026/06/15 07:33 PHST- 2025/08/05 00:00 [received] PHST- 2026/02/27 00:00 [revised] PHST- 2026/03/02 00:00 [accepted] PHST- 2026/06/15 12:51 [medline] PHST- 2026/06/15 12:50 [pubmed] PHST- 2026/06/15 07:33 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - 10.1177_23779608261433684 [pii] AID - 10.1177/23779608261433684 [doi] PST - epublish SO - SAGE Open Nurs. 2026 Jun 12;12:23779608261433684. doi: 10.1177/23779608261433684. eCollection 2026 Jan-Dec. PMID- 42292640 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 5 DP - 2026 May 31 TI - Combining bioinformatics and machine learning to identify common mechanisms and biomarkers of childhood asthma and obesity. PG - 182 LID - 10.21037/tp-2026-1-0108 [doi] LID - 182 AB - BACKGROUND: Childhood asthma (CA), a chronic inflammatory disorder of the airways, and childhood obesity (CO), characterized by low-grade systemic inflammation, frequently coexist. This study seeks to elucidate shared biological mechanisms underlying CA and CO and to identify potential biomarkers via comprehensive bioinformatics analyses of public datasets. METHODS: CA and CO gene expression datasets were retrieved from the Gene Expression Omnibus (GEO). Differentially expressed genes (DEGs) common to both conditions were identified, with hub genes (HGs) screened via four machine learning (ML) algorithms. The diagnostic performance of candidate HGs was evaluated utilizing receiver operating characteristic (ROC) curve analysis. Functional characterization was conducted utilizing Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis, and single-gene gene set enrichment analysis (GSEA). In addition, competitive endogenous RNA (ceRNA) networks were constructed to further explore regulatory relationships and shared pathogenic mechanisms. RESULTS: There were 25 key genes closely linked to CA and CO identified. Enrichment analyses indicated the main involvement of these genes in immune and inflammatory responses, as well as extracellular matrix organization and tissue remodeling. ML analyses ultimately identified NTRK2 and RGS1 as HGs, which demonstrated favorable diagnostic performance in ROC analyses. Furthermore, a ceRNA regulatory network comprising 104 long noncoding RNAs (lncRNAs), 80 microRNAs (miRNAs), and the two HGs was constructed. CONCLUSIONS: This study identified NTRK2 and RGS1 as key HGs shared between CA and CO, presenting fresh insights into their common pathogenic mechanisms. These findings possibly contribute to developing improved diagnostic biomarkers and targeted therapeutic strategies for CA comorbid with obesity. CI - (c) AME Publishing Company. FAU - Gou, Hao AU - Gou H AD - Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, China. AD - Department of Pediatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China. FAU - Zhou, Hongyun AU - Zhou H AD - Department of Pediatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China. FAU - Zhao, Mengjie AU - Zhao M AD - Department of Pediatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China. FAU - Zhang, Xiaojin AU - Zhang X AD - Department of Library, Chengdu University of Traditional Chinese Medicine, Chengdu, China. FAU - Zhao, Qiong AU - Zhao Q AD - Clinical Medical College, Chengdu University of Traditional Chinese Medicine, Chengdu, China. AD - Department of Pediatrics, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China. LA - eng PT - Journal Article DEP - 20260424 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13263428 OTO - NOTNLM OT - Childhood asthma (CA) OT - bioinformatics OT - childhood obesity (CO) OT - machine learning (ML) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-1-0108/coif). The authors have no conflicts of interest to declare. EDAT- 2026/06/15 12:48 MHDA- 2026/06/15 12:49 PMCR- 2026/05/31 CRDT- 2026/06/15 07:29 PHST- 2026/01/27 00:00 [received] PHST- 2026/04/03 00:00 [accepted] PHST- 2026/06/15 12:49 [medline] PHST- 2026/06/15 12:48 [pubmed] PHST- 2026/06/15 07:29 [entrez] PHST- 2026/05/31 00:00 [pmc-release] AID - tp-15-05-182 [pii] AID - 10.21037/tp-2026-1-0108 [doi] PST - ppublish SO - Transl Pediatr. 2026 May 31;15(5):182. doi: 10.21037/tp-2026-1-0108. Epub 2026 Apr 24. PMID- 42291859 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 5 DP - 2026 May TI - Caregiver Feeding Practices and Their Association With Nutritional Status in Children Aged 0-5 Years: A Descriptive Cross-Sectional Study From a Tertiary Care Center in North India. PG - e108756 LID - 10.7759/cureus.108756 [doi] LID - e108756 AB - Background Adequate nutrition in the first five years of life is critical for optimal physical growth, cognitive development, and long-term health outcomes. Caregiver feeding practices are an important factor associated with nutritional outcomes in young children with a spectrum of behaviors ranging from responsive feeding to more controlling strategies. While responsive feeding has been linked to better growth outcomes, the impact of specific feeding behaviors on child nutritional status in tertiary pediatric settings in North India remains poorly characterized. Therefore, this study aimed to evaluate caregiver feeding practices using a validated tool and examine their association with nutritional status in children aged 0-5 years. Objectives The objective of this study is to assess caregiver feeding practices using the Feeding Practices and Structure Questionnaire (FPSQ) and examine their association with nutritional status (Indian Academy of Pediatrics IAP grading) in children aged 0-5 years attending the outpatient department of a tertiary care pediatric center, in order to identify feeding behaviors associated with malnutrition in this setting. Materials and methods A descriptive cross-sectional study was carried out over a period of three months in the outpatient department of pediatrics at Christian Medical College, Ludhiana. A total of 150 caregivers of children aged 0-5 years were enrolled. After obtaining informed consent, each caregiver was administered a structured questionnaire (Feeding Practices and Structure Questionnaire FPSQ), which is a validated tool assessing both feeding practices and feeding patterns. Simultaneously, anthropometric measurements of the children were recorded, and their nutritional status was classified using the Indian Academy of Pediatrics (IAP) grading system. The collected data were analyzed to assess the association between feeding behavior and nutritional status. Results Out of 150 children, 83.3% were normally nourished, 16% had mild malnutrition, and 0.7% had moderate malnutrition. Responsive feeding behaviors such as feeding on demand and shared family meals were the most commonly reported practices. In the milk-feeding group, feeding on demand showed a significant association with better nutritional status (p = 0.015). In the semi-solid group, parent-led feeding was significantly associated with malnutrition (p = 0.008). Conclusion Feeding on demand was associated with better nutritional outcomes in milk-fed children, while parent-led feeding was associated with malnutrition in the semi-solid-feeding group. These findings are hypothesis-generating, given the cross-sectional design, and reverse causality cannot be excluded. Responsive feeding counseling may be a relevant avenue for nutritional improvement in routine pediatric outpatient care. CI - Copyright (c) 2026, John et al. FAU - John, Sharon R AU - John SR AD - Pediatrics and Child Health, Christian Medical College and Hospital, Ludhiana, Ludhiana, IND. FAU - Singh, Ruby AU - Singh R AD - Pediatrics and Child Health, Christian Medical College and Hospital, Ludhiana, Ludhiana, IND. LA - eng PT - Journal Article DEP - 20260512 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13260016 OTO - NOTNLM OT - anthropometry OT - caregivers' influence OT - children OT - feeding pattern OT - malnutrition COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. The Institutional Ethics Committee of Christian Medical College, Ludhiana, issued approval IECBMHR/202411-506/Apprvl-STS-Proj/CMC&H. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/06/15 12:50 MHDA- 2026/06/15 12:51 PMCR- 2026/05/12 CRDT- 2026/06/15 07:23 PHST- 2026/04/02 00:00 [received] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/06/15 12:51 [medline] PHST- 2026/06/15 12:50 [pubmed] PHST- 2026/06/15 07:23 [entrez] PHST- 2026/05/12 00:00 [pmc-release] AID - 10.7759/cureus.108756 [doi] PST - epublish SO - Cureus. 2026 May 12;18(5):e108756. doi: 10.7759/cureus.108756. eCollection 2026 May. PMID- 42291790 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2667-3681 (Electronic) IS - 2667-3681 (Linking) VI - 19 DP - 2026 Sep TI - Development of program requirements for obesity medicine fellowship training in the U.S. PG - 100282 LID - 10.1016/j.obpill.2026.100282 [doi] LID - 100282 AB - BACKGROUND: Subspecialty fellowship training programs typically adhere to program requirements for graduate medical education for their field, which are established by accreditation organizations. However, US-based obesity medicine fellowships currently lack this guidance. Therefore, our objective was to develop and validate subspecialty fellowship program requirements for both adult and pediatric obesity medicine in the US. METHODS: A work group from the Obesity Medicine Fellowship Council (OMFC) was convened to define program requirements for obesity medicine (OM) fellowships, including standards for curricular and clinical experiences during training. Draft program requirements for adult OM and pediatric OM fellowships were developed through an iterative consensus group process with repeated cycles of drafting and revising by an expert work group who then gained input from the American Board of Obesity Medicine and leadership from all OMFC-recognized fellowship programs. The draft documents were subsequently revised and then validated through a national survey to all US-based OM fellowship programs, where adult OM fellowships evaluated the adult OM program requirements and pediatric OM fellowships evaluated the pediatric OM program requirements. Respondents were asked to 'approve'/'not approve' each proposed section with space for comments. An agreement of at least 75% among respondents was set as the threshold a priori for retaining a program requirement. RESULTS: Representatives from all adult and pediatric OM fellowship programs participated in the survey (n = 31). All items met the minimum threshold of >/=75% approving the requirement for both adult and pediatric OM fellowship programs. Comments for revisions on specific elements were primarily related to changes in language and formatting rather than conceptual underpinnings. CONCLUSION: A group consensus method strengthened by inclusion of a national survey of OM fellowship program directors resulted in carefully-developed and broadly-vetted program requirements. These OM fellowship program requirements offer educators and trainees a roadmap to develop comprehensive OM training. CI - (c) 2026 The Authors. FAU - Schmidt, Stacy L AU - Schmidt SL AD - Obesity Medicine Fellowship Council, Denver, CO, USA. FAU - Sabet, Amin AU - Sabet A AD - University of Massachusetts Chan Medical School, Worcester, MA, USA. FAU - Wong, Denise H AU - Wong DH AD - Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. FAU - Gilden, Adam H AU - Gilden AH AD - University of Colorado School of Medicine, Aurora, CO, USA. FAU - Wickham, Edmond P AU - Wickham EP AD - Virginia Commonwealth University School of Medicine, Richmond, VA, USA. FAU - Raatz, Sarah AU - Raatz S AD - University of Minnesota Medical School, Minneapolis, MN, USA. FAU - Fox, Claudia K AU - Fox CK AD - University of Minnesota Medical School, Minneapolis, MN, USA. FAU - Gudzune, Kimberly A AU - Gudzune KA AD - Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. LA - eng PT - Journal Article DEP - 20260608 PL - United States TA - Obes Pillars JT - Obesity pillars JID - 9918697364706676 PMC - PMC13263674 OTO - NOTNLM OT - Clinical competence OT - Obesity management OT - Specialty boards COIS- The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Stacy Schmidt reports financial support was provided by Novo Nordisk Inc. Edmond P. Wickham 3rd reports a relationship with Novo Nordisk that includes: funding grants. Sarah Raatz reports a relationship with Novo Nordisk that includes: funding grants. Sarah Raatz reports a relationship with Eli Lilly and Company that includes: funding grants. Claudia K. Fox reports a relationship with Novo Nordisk Inc that includes: funding grants. Claudia K. Fox reports a relationship with Eli Lilly and Company that includes: funding grants. Amin Sabet reports a relationship with Abbott Laboratories that includes: equity or stocks. Amin Sabet reports a relationship with AbbVie that includes: equity or stocks. Amin Sabet reports a relationship with Eli Lilly and Company that includes: equity or stocks. Amin Sabet reports a relationship with Johnson and Johnson that includes: equity or stocks. Amin Sabet reports a relationship with Merck & Co Inc that includes: equity or stocks. Amin Sabet reports a relationship with Novo Nordisk that includes: equity or stocks. Kimberly A. Gudzune reports a relationship with Novo Nordisk Inc that includes: consulting or advisory, funding grants, and travel reimbursement. Kimberly A. Gudzune reports a relationship with Eli Lilly and Company that includes: consulting or advisory and travel reimbursement. Kimberly A. Gudzune has patent with royalties paid to Johns Hopkins ACG System. Given his role as an editor for Obesity Pillars, Amin Sabet had no involvement in the peer review of this article and had no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to another journal editor. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/15 12:50 MHDA- 2026/06/15 12:51 PMCR- 2026/06/08 CRDT- 2026/06/15 07:22 PHST- 2026/05/06 00:00 [received] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/06/15 12:51 [medline] PHST- 2026/06/15 12:50 [pubmed] PHST- 2026/06/15 07:22 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - S2667-3681(26)00038-0 [pii] AID - 100282 [pii] AID - 10.1016/j.obpill.2026.100282 [doi] PST - epublish SO - Obes Pillars. 2026 Jun 8;19:100282. doi: 10.1016/j.obpill.2026.100282. eCollection 2026 Sep. PMID- 42291610 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 1682-024X (Print) IS - 1681-715X (Electronic) IS - 1681-715X (Linking) VI - 42 IP - 5 DP - 2026 May TI - Development and validation of a nomogram for predicting recurrence in epithelial ovarian cancer after primary cytoreductive surgery: A single-center retrospective study. PG - 1148-1156 LID - 10.12669/pjms.42.5.14519 [doi] AB - OBJECTIVE: To explore the risk factors for recurrence of epithelial ovarian cancer (EOC) after primary cytoreductive surgery, and to develop and validate a risk prediction model based on the identified factors. METHODOLOGY: Clinical data of 213 patients with epithelial ovarian cancer (EOC) who underwent primary cytoreductive surgery (CRS) in Huzhou Maternity & Child Health Care Hospital, China from January 2020 to July 2025 were retrospectively collected. Patients were randomly divided into a training (n=128) and a validation cohort (n=85) at a ratio of 6:4. The Least Absolute Shrinkage and Selection Operator (LASSO) regression and multivariable logistic regression were utilized for feature selection in the training cohort to construct a nomogram for predicting postoperative recurrence. The discriminative performance and calibration of the nomogram were evaluated in both cohorts utilizing the area under the receiver operating characteristic curve (AUC) and the Hosmer-Lemeshow test. RESULTS: The EOC recurrence rate was 40.8% (87/213). The analysis identified six independent risk factors for predicting recurrence, including International Federation of Gynecology and Obstetrics (FIGO) stage, differentiation grade, residual lesions, positive ascites cytology, carbohydrate antigen 125 (CA125) positive, and positive Risk of Ovarian Malignancy Algorithm (ROMA) index. The nomogram model demonstrated sufficient predictive accuracy, with AUC values of 0.861 (95%CI: 0.795-0.928) and 0.801 (95%CI: 0.697-0.904) in the training and validation cohorts, respectively. The results of the H-L test showed good fitness. CONCLUSIONS: The nomogram model developed in this study exhibits good predictive performance and applicability, and can be used to screen for the risk of recurrence in this population. CI - Copyright: (c) Pakistan Journal of Medical Sciences. FAU - Zhang, Weifeng AU - Zhang W AD - Weifeng Zhang Department of Gynecology, Huzhou Maternity & Child Health Care Hospital,Huzhou, Zhejiang Province 313000, P.R. China. FAU - Shu, Yan AU - Shu Y AD - Yan Shu Department of Ultrasound, Huzhou Maternity & Child Health Care Hospital,Huzhou, Zhejiang Province 313000, P.R. China. FAU - Wan, Zeqiu AU - Wan Z AD - Zeqiu Wan Department of Gynecology, Huzhou Maternity & Child Health Care Hospital,Huzhou, Zhejiang Province 313000, P.R. China. FAU - Yang, Shuying AU - Yang S AD - Shuying Yang, Huzhou Maternity & Child Health Care Hospital,Huzhou, Zhejiang Province 313000, P.R. China. LA - eng PT - Journal Article PL - Pakistan TA - Pak J Med Sci JT - Pakistan journal of medical sciences JID - 100913117 PMC - PMC13263576 OTO - NOTNLM OT - Cytoreductive surgery OT - Epithelial ovarian cancer OT - Prediction OT - Primary OT - Recurrence EDAT- 2026/06/15 12:53 MHDA- 2026/06/15 12:54 PMCR- 2026/05/01 CRDT- 2026/06/15 07:21 PHST- 2025/11/21 00:00 [received] PHST- 2025/11/27 00:00 [revised] PHST- 2026/03/23 00:00 [revised] PHST- 2026/04/08 00:00 [accepted] PHST- 2026/06/15 12:54 [medline] PHST- 2026/06/15 12:53 [pubmed] PHST- 2026/06/15 07:21 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - PJMS-42-5-1148 [pii] AID - 10.12669/pjms.42.5.14519 [doi] PST - ppublish SO - Pak J Med Sci. 2026 May;42(5):1148-1156. doi: 10.12669/pjms.42.5.14519. PMID- 42290922 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2673-6101 (Electronic) IS - 2673-6101 (Print) IS - 2673-6101 (Linking) VI - 7 DP - 2026 TI - An online program focusing on modifiable lifestyle and environmental interventions was associated with improved pediatric eczema symptoms: results from a retrospective observational study. PG - 1759379 LID - 10.3389/falgy.2026.1759379 [doi] LID - 1759379 AB - BACKGROUND: Pediatric eczema is a highly prevalent condition that often causes substantial suffering among affected children and their families. The goal of this study was to evaluate the effects of an integrative program for parents of children with eczema that simultaneously addressed multiple modifiable lifestyle and environmental risk factors. METHODS: Children with eczema diagnosis who began the online eczema program and provided outcomes data from May 2024 to May 2025 were eligible. The primary outcome was the Patient-Oriented Scoring Atopic Dermatitis (PO-SCORAD), a validated measure of eczema symptoms and burden. Outcomes were assessed at baseline and at one month, two months, and six months after beginning the program. Changes in mean PO-SCORAD scores from baseline throughout the duration of the study were assessed with analysis of variance (ANOVA). Multivariate linear regression modeling of PO-SCORAD scores using population-averaged generalized estimating equations (GEE) were also constructed accounting for baseline PO-SCORAD scores and adjusting for age, sex, presence of any allergy, use of topical corticosteroids, and use of antihistamines. RESULTS: 197 participants were included in the study. The mean baseline PO-SCORAD score was 51.4, which is considered severe eczema. PO-SCORAD scores improved over the course of the study (p < 0.0001) and there were statistically significant and clinically meaningful improvements noted after one month (11.3 points, 22.0% improvement), two months (17.8 points, 34.6% improvement), and six months (27.2 points, 52.9% improvement) in the program (p < 0.0001). After accounting for baseline PO-SCORAD scores and covariates in regression modeling, there was a 22.5-point (p < 0.0001) improvement in PO-SCORAD scores from baseline to final assessment. There was a 31.4-point decrease in PO-SCORAD scores from baseline to final assessment (p < 0.0001, 47.2% improvement) among the subgroup of participants with severe eczema symptoms at baseline. CONCLUSIONS: An online program focusing on modifiable lifestyle and environmental modifications was associated with clinically meaningful symptom improvements among children with eczema. Symptoms improved relatively quickly and the greatest improvements were noted among children with severe symptoms at baseline. Further prospective studies will help generate more conclusive evidence of the causal effects of multimodal intervention focused on modifiable lifestyle factors and environmental exposures on pediatric eczema symptoms. CI - (c) 2026 Temple, Golden, Temple and D'Adamo. FAU - Temple, Ana-Maria AU - Temple AM AD - Integrative Health Carolinas, Charlotte, NC, United States. FAU - Golden, Desta AU - Golden D AD - Global Integrative Health Institute, Charlotte, NC, United States. FAU - Temple, John D AU - Temple JD AD - Integrative Health Carolinas, Charlotte, NC, United States. FAU - D'Adamo, Christopher R AU - D'Adamo CR AD - OvationLab, Richmond, VA, United States. AD - Documenting Hope, Windsor, CT, United States. AD - Department of Family and Community Medicine, University of Maryland School of Medicine, Baltimore, MD, United States. LA - eng SI - figshare/10.6084/m9.figshare.30647390 PT - Journal Article DEP - 20260529 PL - Switzerland TA - Front Allergy JT - Frontiers in allergy JID - 9918227355906676 PMC - PMC13260383 OTO - NOTNLM OT - eczema OT - environmental toxins OT - functional medicine OT - integrative medicine OT - microbiome OT - nutrition OT - pediatric OT - stress COIS- AMT and JT are owners of Integrative Health Courses. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/15 12:51 MHDA- 2026/06/15 12:52 PMCR- 2026/05/29 CRDT- 2026/06/15 07:16 PHST- 2025/12/02 00:00 [received] PHST- 2026/04/13 00:00 [revised] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/06/15 12:52 [medline] PHST- 2026/06/15 12:51 [pubmed] PHST- 2026/06/15 07:16 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - 10.3389/falgy.2026.1759379 [doi] PST - epublish SO - Front Allergy. 2026 May 29;7:1759379. doi: 10.3389/falgy.2026.1759379. eCollection 2026. PMID- 42290744 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260615 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Translation, cross-cultural adaptation and preliminary application of the premature infant oral motor intervention in Chinese neonatal nursing practice: a pilot randomized controlled trial. PG - 1784065 LID - 10.3389/fped.2026.1784065 [doi] LID - 1784065 AB - BACKGROUND: Oral motor intervention plays a critical role in facilitating nutritional intake and supporting neurodevelopmental outcomes in preterm infants. The Premature Infant Oral Motor Intervention (PIOMI) is a standardized, five-minute, eight-step manual protocol designed to enhance oral-motor skills and sucking performance in very preterm infants. AIM: To translate, culturally adapt, and preliminarily validate the PIOMI for neonatal nurses in mainland China, and to pilot-test its clinical feasibility and preliminary efficacy on oral sucking performance in very-preterm infants. DESIGN: This study employed a two-phase translation and testing approach. Phase 1 comprised Brislin's six-step translation, a two-round electronic Delphi (e-Delphi) process, and assessment of content validity and implementation consistency. Phase 2 involved a parallel-group pilot randomized controlled trial. METHODS: This study cross-culturally adapted the Premature Infant Oral Motor Intervention (PIOMI) into Chinese using Brislin's framework, finalized the mainland Chinese version (CMV-PIOMI) via a two-round e-Delphi expert consensus (n = 21), assessed its implementation consistency (n = 117), and evaluated its efficacy on preterm infants' oral sucking ability through a randomized controlled trial (n = 76). RESULTS: The Delphi response rate was 85.71% (n = 18), I-CVI ranged from 0.88 to 1.00, and S-CVI/Ave was 0.96, with six amendments incorporated. Among the 117 NICU nurses, the Pearson correlation coefficient for implementation consistency was 0.68 (p < 0.001), and paired CMV-PIOMI operational scores did not differ systematically (27.95 +/- 0.48 vs. 27.99 +/- 0.45, p = 0.266). In the pilot RCT (n = 76), baseline characteristics were comparable, and the proportion of preterm infants with normal sucking patterns was higher in the intervention group (50.0%) than in the control group (21.1%) (95% CI: 7.0% to 47.2%; p = 0.008). CONCLUSIONS: The Chinese PIOMI shows satisfactory content validity and acceptable implementation consistency and is feasible for delivery by bedside nurses. Preliminary evidence suggests improved oral sucking performance in very preterm infants, but larger, fully powered multicenter trials are needed to confirm these initial findings.Clinical Trial Registration: Chinese Clinical Trial Registry (ChiCTR) ID: ChiCTR2300070320. CI - (c) 2026 Wu, Chen, Fu, Ding, Wu, Yuan and Zhou. FAU - Wu, Nana AU - Wu N AD - Neonatal Intensive Care Unit, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Chen, Xia AU - Chen X AD - Neonatal Intensive Care Unit, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Fu, Jie AU - Fu J AD - Neonatal Intensive Care Unit, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Ding, Liwen AU - Ding L AD - Neonatal Intensive Care Unit, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Wu, Shuang AU - Wu S AD - Neonatal Intensive Care Unit, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Yuan, Sushan AU - Yuan S AD - Neonatal Intensive Care Unit, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. FAU - Zhou, Hong AU - Zhou H AD - Neonatal Intensive Care Unit, Chengdu Women's and Children's Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China. LA - eng PT - Journal Article DEP - 20260529 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13260545 OTO - NOTNLM OT - PIOMI OT - cross-cultural adaptation OT - e-Delphi OT - premature infants OT - translation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/15 12:50 MHDA- 2026/06/15 12:51 PMCR- 2026/05/29 CRDT- 2026/06/15 07:15 PHST- 2026/01/09 00:00 [received] PHST- 2026/03/23 00:00 [revised] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/06/15 12:51 [medline] PHST- 2026/06/15 12:50 [pubmed] PHST- 2026/06/15 07:15 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - 10.3389/fped.2026.1784065 [doi] PST - epublish SO - Front Pediatr. 2026 May 29;14:1784065. doi: 10.3389/fped.2026.1784065. eCollection 2026. PMID- 42290410 OWN - NLM STAT- MEDLINE DCOM- 20260615 LR - 20260918 IS - 1879-8365 (Electronic) IS - 0926-9630 (Linking) VI - 337 DP - 2026 Jun 15 TI - Side-Shift Therapy as Translation-Dominant 3D Auto-Correction in Adolescent Idiopathic Scoliosis: A Clinical-Mathematical Framework for Stratified PSSE. PG - 6-10 LID - 10.3233/SHTI260733 [doi] AB - Adolescent idiopathic scoliosis (AIS) is a three-dimensional deformity characterised by coronal curvature, axial rotation, and altered trunk translation. Radiographic indices (e.g., Cobb angle) quantify structure but incompletely represent functional correctability, a core target of physiotherapeutic scoliosis-specific exercises (PSSE). Side-Shift Therapy (SST), originating from the RNOH tradition (Mehta, 1985) and operationalised via a mobility classification (Betts et al., 2014), is a voluntary lateral translation of the trunk relative to the pelvis (not a side-bend). This paper presents a biomechanics-first teaching framework linking functional spinal unit (FSU) mechanics, thoracic ring behaviour, motor control sequencing, and growth-modulation hypotheses. FSUs are modelled as 6-DOF systems with translation-rotation coupling; in simplified terms, Ktt represents resistance to translation and Ktr represents how rotation changes when translation is performed (short note: coupling = rotation response during translation). Load-path optimisation is framed via an apical bending moment approximation M approximately Fg.dlat (dlat = lateral moment arm). Time-under-load is explained using viscoelastic forms where eta captures time-dependence. In growing spines, a Hueter-Volkmann-type simplification gdot = g0 - ksigma is used to describe stress-sensitive growth (k = stress sensitivity). Clinically, original mobility Types (1: beyond midline; 2: to midline; 3: cannot reach midline) are retained with reported substantial reliability (kappa approximately 0.76-0.77). A multiplanar update adds transverse modifiers for Types 1-2: A (rotation reduces), B (rotation persists), C (rotation worsens), providing a pragmatic proxy for coupling behaviour and thoracic compliance. The framework supports stratified PSSE prescription and outlines testable targets for reliability, responsiveness, and predictive validity. FAU - Betts, Tony AU - Betts T AD - Royal National Orthopaedic Hospital (RNOH), Stanmore, UK. CN - Scoliosis Interest Group (SIG) LA - eng PT - Journal Article PL - Netherlands TA - Stud Health Technol Inform JT - Studies in health technology and informatics JID - 9214582 SB - IM MH - *Scoliosis/physiopathology/therapy/rehabilitation MH - Humans MH - Adolescent MH - Biomechanical Phenomena MH - *Exercise Therapy/methods OTO - NOTNLM OT - PSSE OT - Side Shift Therapy EDAT- 2026/06/15 11:37 MHDA- 2026/06/15 12:49 CRDT- 2026/06/15 05:43 PHST- 2026/06/15 12:49 [medline] PHST- 2026/06/15 11:37 [pubmed] PHST- 2026/06/15 05:43 [entrez] AID - SHTI260733 [pii] AID - 10.3233/SHTI260733 [doi] PST - ppublish SO - Stud Health Technol Inform. 2026 Jun 15;337:6-10. doi: 10.3233/SHTI260733. PMID- 42290215 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261012 IS - 1098-108X (Electronic) IS - 0276-3478 (Linking) VI - 59 IP - 10 DP - 2026 Oct TI - Structural Validity of a Short Form of the Eating Disorder Examination Questionnaire in Adolescents Diagnosed With an Eating Disorder. PG - 2196-2206 LID - 10.1002/eat.70146 [doi] AB - OBJECTIVE: This study aimed to assess the structural validity and readability of a brief 7-item version of the Eating Disorder Examination Questionnaire (the EDE-Q7) among adolescents. METHOD: Latent variable analysis was used in a sample of 263 adolescents (age range = 13-17.99y) diagnosed with an eating disorder and recruited from treatment centres in the United States of America and Australia. Several indices were used to provide different estimates of overall model fit. RESULTS: The EDE-Q7 showed good fit to the data, although absolute fit indices suggested some evidence of imperfect fit. Several other models (both brief and full-item versions) failed to meet most criteria indicating good fit. The subscales of the EDE-Q7 showed significant correlations with several disordered eating behaviors, suggesting convergent validity. Review of the EDE-Q7 suggests ease of readability for adolescents from at least 11 years of age. DISCUSSION: This is one of the first clinical studies to support the EDE-Q7 as a brief, valid assessment of eating psychopathology that can be used with adolescents as well as adults. The results indicate that the EDE-Q7 might be appropriate for assessing eating pathology among adolescents from the age of 13 years. CI - (c) 2026 The Author(s). International Journal of Eating Disorders published by Wiley Periodicals LLC. FAU - Jenkins, Paul E AU - Jenkins PE AUID- ORCID: 0000-0003-1673-2903 AD - School of Psychology and Clinical Language Sciences, University of Reading, Reading, UK. FAU - Gorrell, Sasha AU - Gorrell S AUID- ORCID: 0000-0002-8861-8547 AD - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA. FAU - Accurso, Erin C AU - Accurso EC AUID- ORCID: 0000-0002-5521-6381 AD - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA. AD - Philip R. Lee Institute for Health Policy Studies, University of California San Francisco, San Francisco, California, USA. FAU - Eckhardt, Sarah AU - Eckhardt S AUID- ORCID: 0000-0003-0824-4328 AD - Center for the Treatment of Eating Disorders, Children's Minnesota, St Paul, Minnesota, USA. FAU - Hughes, Elizabeth K AU - Hughes EK AUID- ORCID: 0000-0002-4377-5610 AD - Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia. AD - Murdoch Children's Research Institute, Parkville, Victoria, Australia. FAU - Le Grange, Daniel AU - Le Grange D AUID- ORCID: 0000-0001-7293-9496 AD - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, California, USA. FAU - Sawyer, Susan M AU - Sawyer SM AUID- ORCID: 0000-0002-9095-358X AD - Department of Paediatrics, The University of Melbourne, Parkville, Victoria, Australia. AD - Murdoch Children's Research Institute, Parkville, Victoria, Australia. AD - Centre for Adolescent Health, Royal Children's Hospital, Parkville, Victoria, Australia. FAU - Rienecke, Renee D AU - Rienecke RD AUID- ORCID: 0000-0003-0423-7403 AD - Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, Illinois, USA. LA - eng GR - Baker Foundation/ GR - Victorian Government's Operational Infrastructure Support Program/ GR - Goven Family Foundation/ PT - Journal Article PT - Validation Study DEP - 20260615 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - Adolescent MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Surveys and Questionnaires/standards MH - Female MH - Reproducibility of Results MH - Psychometrics MH - Male MH - Australia OTO - NOTNLM OT - assessment OT - eating disorder examination-questionnaire OT - latent variable analysis OT - patient-reported outcome measures OT - psychometrics OT - readability EDAT- 2026/06/15 11:37 MHDA- 2026/10/12 11:41 CRDT- 2026/06/15 03:33 PHST- 2026/05/28 00:00 [revised] PHST- 2026/02/27 00:00 [received] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/10/12 11:41 [medline] PHST- 2026/06/15 11:37 [pubmed] PHST- 2026/06/15 03:33 [entrez] AID - 10.1002/eat.70146 [doi] PST - ppublish SO - Int J Eat Disord. 2026 Oct;59(10):2196-2206. doi: 10.1002/eat.70146. Epub 2026 Jun 15. PMID- 42290012 OWN - NLM STAT- MEDLINE DCOM- 20260615 LR - 20260813 IS - 2314-6141 (Electronic) IS - 2314-6133 (Print) VI - 2026 IP - 1 DP - 2026 TI - Accuracy and Reliability of Dental Age Estimation Methods in Iranian Children: A Systematic Review and Meta-Analysis. PG - e9351167 LID - 10.1155/bmri/9351167 [doi] LID - 9351167 AB - OBJECTIVES: This study is aimed at systematically evaluating the accuracy and reliability of dental age (DA) estimation methods and conducting a meta-analysis of studies on different DA estimation methods in Iranian children. METHODS: A systematic search of English and Persian literature from database inception to March 2024 was conducted across international and national databases to identify eligible studies on DA estimation using radiographs in Iranian children. Studies that used dental radiographs from healthy individuals aged 3-18 years and reported the mean difference (MD) between DA and chronological age (CA) were included. The meta-analysis calculated the MD between dental and chronological age, with 95% confidence intervals (CIs), to assess the applicability of the DA method for estimating CA in the Iranian population. RESULTS: Twenty-seven eligible published articles were included in this study. Demirjian's method overestimated age (overall MD: males: +0.784 years; females: +0.323 years). Among the alternative methods studied in the systematic review, Moorrees and Nolla's methods tended to underestimate age, whereas Cameriere, Smith, and London Atlas'methods tended to overestimate age. CONCLUSION: Most methods studied consistently overestimated age and should be used cautiously in forensic age estimation, underscoring the importance of tailoring methods such as the Demarjian method for the Iranian population to ensure accuracy and relevance in professional practice. Additional studies employing similar methodologies and focusing on the customization of dental age estimation methods are recommended to improve accuracy and applicability across diverse populations. CI - Copyright (c) 2026 Razieh Jabbarian et al. BioMed Research International published by John Wiley & Sons Ltd. FAU - Jabbarian, Razieh AU - Jabbarian R AUID- ORCID: 0000-0002-9142-8998 AD - Department of Pediatric Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran, qums.ac.ir. FAU - Ranjbaran, Mehdi AU - Ranjbaran M AUID- ORCID: 0000-0002-0313-3373 AD - Department of Epidemiology and Biostatistics, Non-Communicable Diseases Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran, qums.ac.ir. FAU - Mokhlesi, Aida AU - Mokhlesi A AUID- ORCID: 0000-0003-1612-1571 AD - Social Determinants of Health Research Center, Research Institute for Prevention of Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran, qums.ac.ir. AD - USERN Office, Qazvin University of Medical Sciences, Qazvin, Iran, qums.ac.ir. AD - Student Research Committee, School of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran, qums.ac.ir. AD - Network of Interdisciplinarity in Neonates and Infants (NINI), Universal Scientific Education and Research Network (USERN), Tehran, Iran, usern.tums.ac.ir. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review PL - United States TA - Biomed Res Int JT - BioMed research international JID - 101600173 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Child MH - Iran MH - Child, Preschool MH - Reproducibility of Results MH - Adolescent MH - Female MH - Male MH - *Tooth/diagnostic imaging PMC - PMC13265831 OTO - NOTNLM OT - Demirjian's method OT - Iranian children OT - chronological age OT - dental age estimation OT - meta-analysis OT - systematic review COIS- The authors declare no conflicts of interest. EDAT- 2026/06/15 11:37 MHDA- 2026/06/15 11:38 PMCR- 2026/06/14 CRDT- 2026/06/15 01:53 PHST- 2026/02/08 00:00 [revised] PHST- 2024/07/29 00:00 [received] PHST- 2026/03/04 00:00 [accepted] PHST- 2026/06/15 11:38 [medline] PHST- 2026/06/15 11:37 [pubmed] PHST- 2026/06/15 01:53 [entrez] PHST- 2026/06/14 00:00 [pmc-release] AID - BMRI9351167 [pii] AID - 10.1155/bmri/9351167 [doi] PST - ppublish SO - Biomed Res Int. 2026;2026(1):e9351167. doi: 10.1155/bmri/9351167. PMID- 42289808 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260824 IS - 1522-726X (Electronic) IS - 1522-1946 (Print) IS - 1522-1946 (Linking) VI - 108 IP - 2 DP - 2026 Aug TI - Percutaneous Deployment of the Sinus-SuperFlex-DS Stent for Hybrid Stage I Palliation in Neonates Weighing 0.70), and both EFA and CFA supported the scale's overall construct validity. In terms of performance patterns, students scored relatively higher in the dimensions related to cherishing food and reducing waste as well as food culture inheritance, while comparatively lower scores were observed in balanced dietary concepts and local production-local consumption. Differences in food literacy were also associated with school types, regional contexts, and family food practices. CONCLUSIONS: The Food Education Scale provides a validated instrument for assessing food literacy among upper elementary school students in Taiwan. The findings provide a validated, policy-aligned instrument for assessing children's food literacy and offer practical guidance for curriculum design and sustainability-oriented food education policies. CI - (c) 2026. The Author(s). FAU - Lai, Li-Jiuan AU - Lai LJ AD - Department of Environmental and Cultural Resources, National Tsing Hua University, No.101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan, R. O. C. FAU - Tseng, Tzuhui Angie AU - Tseng TA AD - Department of Environmental and Cultural Resources, National Tsing Hua University, No.101, Section 2, Kuang-Fu Road, Hsinchu, 30013, Taiwan, R. O. C.. thtseng@mx.nthu.edu.tw. LA - eng PT - Journal Article PT - Validation Study DEP - 20260613 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - Taiwan MH - Child MH - Female MH - Surveys and Questionnaires/standards MH - Male MH - *Students MH - Reproducibility of Results MH - Schools MH - Psychometrics MH - *Health Literacy MH - *Health Education/methods MH - Factor Analysis, Statistical PMC - PMC13491723 OTO - NOTNLM OT - Elementary school students OT - Food education OT - Food literacy OT - Scale development OT - Sustainability education COIS- Declarations. Ethics approval and consent to participate: The study was reviewed and approved by the Institutional Review Board of National Tsing Hua University, Taiwan (Approval No. 11204HT042), ensuring adherence to ethical standards. Consent for publication: All authors have read and approved the final version of this manuscript and consent to its publication in the journal. The authors confirm that the work has not been published previously and is not under consideration for publication elsewhere. Competing interests: The authors declare no competing interests. EDAT- 2026/06/15 11:32 MHDA- 2026/08/20 05:43 PMCR- 2026/06/13 CRDT- 2026/06/13 23:36 PHST- 2025/11/25 00:00 [received] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/08/20 05:43 [medline] PHST- 2026/06/15 11:32 [pubmed] PHST- 2026/06/13 23:36 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 10.1186/s12966-026-01925-w [pii] AID - 1925 [pii] AID - 10.1186/s12966-026-01925-w [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2026 Jun 13;23(1):77. doi: 10.1186/s12966-026-01925-w. PMID- 42288815 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 13 TI - Exploring the relationship between social media use, eating behaviors, and depression in young women: a machine learning-based cross-sectional study. LID - 10.1186/s12889-026-28138-x [doi] LID - 2247 AB - BACKGROUND: The increasing prevalence of social media use among young adults has raised concerns regarding its potential associations with mental health and eating behaviors. The aim of this study was to investigate the associations between social media use, eating behaviors, and depressive symptoms among young women and to evaluate the performance of machine learning algorithms in modeling these cross-sectional associations compared with conventional regression approaches. METHODS: A cross-sectional study was conducted among young women aged 18-34 years (n = 4,692) using a multi-site, face-to-face convenience sampling strategy. The survey collected data on BMI, patterns of social media use, the Beck Depression Inventory (BDI), and the Scale of Effects of Social Media on Eating Behavior (SESMEB). In addition to standard statistical analyses, various ML models, including Random Forest and Extreme Gradient Boosting (XGBoost), were applied to model SESMEB and BDI scores. Model performance was evaluated using internal validation procedures, including a train-test split and cross-validation, and assessed using root mean square error (RMSE) and mean absolute error (MAE). RESULTS: The mean age of participants was 23.8 years, and the mean BMI was 22.3 kg/m(2). Significant differences in BMI, SESMEB, and BDI scores were observed across social media platform use groups. Users of Facebook, TikTok, and Snapchat reported significantly lower SESMEB scores (p < 0.001). ML models identified BMI, snack intake, and social media use as influential variables associated with SESMEB and BDI scores. Random Forest showed the best modeling performance in the test set for both SESMEB and BDI scores, with XGBoost performing comparably. CONCLUSIONS: Social media use was associated with eating-related behaviors and depressive symptoms in young women. Within the study sample, ML models demonstrated modest modeling performance for SESMEB and BDI scores and may provide a complementary framework for examining complex associations among behavioral and psychological variables. However, these findings were based on internal validation only and require confirmation in independent external samples. Further research is warranted to clarify the direction of these associations, explore platform-specific differences, and evaluate the external validity of these models. CI - (c) 2026. The Author(s). FAU - Altan, Murat AU - Altan M AUID- ORCID: 0000-0002-9561-4755 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Firat University, Elazig, Turkiye. FAU - Kocaman, Semsi Gul Yilmaz AU - Kocaman SGY AUID- ORCID: 0000-0002-2825-7401 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Karamanoglu Mehmetbey University, Karaman, Turkiye. semsigul10@gmail.com. FAU - Ulger, Taha Gokmen AU - Ulger TG AUID- ORCID: 0000-0002-7751-9789 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Bolu Abant Izzet Baysal University, Bolu, Turkiye. FAU - Onal, Seda AU - Onal S AUID- ORCID: 0000-0002-8074-5584 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Firat University, Elazig, Turkiye. FAU - Yildirim, Hasan AU - Yildirim H AUID- ORCID: 0000-0003-4582-9018 AD - Department of Data Science and Analytics, Kamil Ozdag Faculty of Science, Karamanoglu Mehmetbey University, Karaman, Turkiye. LA - eng PT - Journal Article DEP - 20260613 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - *Social Media/statistics & numerical data MH - Young Adult MH - Adult MH - *Depression/epidemiology MH - Adolescent MH - *Feeding Behavior/psychology MH - *Machine Learning MH - Predictive Learning Models MH - Digital Media MH - Media Exposure PMC - PMC13420861 OTO - NOTNLM OT - Artificial intelligence OT - Beck Depression Inventory OT - Body mass index OT - Eating behavior OT - Machine learning OT - Social media COIS- Declarations. Ethics approval and consent to participate: All procedures involving human participants were conducted in accordance with the principles of the Declaration of Helsinki. To protect participant privacy, all names and identifying information were anonymised. Participation was voluntary, and written informed consent was obtained from all participants prior to data collection. No financial compensation was provided for participation. Ethical approval for the study was granted by the Scientific Research and Publication Ethics Committee of Social and Human Sciences, Karamanoglu Mehmetbey University (Decision No: 02-2024/38; approval date: 23/01/2024). The official ethics approval document has been provided as supplementary material for editorial verification (Additional File 1). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/15 11:31 MHDA- 2026/07/31 06:37 PMCR- 2026/06/13 CRDT- 2026/06/13 23:35 PHST- 2026/04/05 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/31 06:37 [medline] PHST- 2026/06/15 11:31 [pubmed] PHST- 2026/06/13 23:35 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 10.1186/s12889-026-28138-x [pii] AID - 28138 [pii] AID - 10.1186/s12889-026-28138-x [doi] PST - epublish SO - BMC Public Health. 2026 Jun 13;26(1):2247. doi: 10.1186/s12889-026-28138-x. PMID- 42288643 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20261023 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 13 TI - Micronutrient intake and food insecurity among mothers of infants with orofacial clefts: a cross-sectional study in Iran. LID - 10.1038/s41598-026-57977-2 [doi] LID - 27066 AB - Cleft lip with or without cleft palate is a common congenital craniofacial anomaly influenced by genetic and environmental factors. This cross-sectional study investigated maternal micronutrient intake and household food insecurity among Iranian mothers of infants with orofacial clefts. Mothers of infants aged 0-12 months with cleft lip (CL), cleft palate (CP), or both were recruited from a referral hospital in Tehran (2019-2020). Dietary intake was assessed using a validated food frequency questionnaire, and food security was evaluated with a standardized instrument. Multinomial logistic regression was performed to examine associations. High prevalences of inadequate intake were observed for iron (91.0%), vitamin D (73.6%), vitamin A (70.6%), folate (60.2%), calcium (56.7%), and vitamin B6 (50.7%). Vitamin B12 inadequacy differed significantly across cleft types (p = 0.023), with higher prevalence in CP (35.8%) and CL/P (38.6%) compared with CL (19.2%). Food insecurity also differed significantly by cleft type (p = 0.024), with hunger reported in 42.9% of the CL/P, 24.5% of the CP, and 20.5% of the CL groups. In multinomial logistic regression (reference: CL), food insecurity without hunger was associated with lower odds of CL/P in the crude model (OR = 0.30, 95% CI: 0.14-0.65), although this association was attenuated after adjustment. However, a significant trend between increasing food insecurity and cleft severity persisted across all models (P-trend = 0.028). These findings highlight the importance of maternal nutrition and food security in preventive strategies. CI - (c) 2026. The Author(s). FAU - Kalantar-Hormozi, Abdoljalil AU - Kalantar-Hormozi A AD - Research and Development Center, 15 Khordad Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Hojaji, Elham AU - Hojaji E AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. elhamhojaji@gmail.com. FAU - Avani, Anita AU - Avani A AD - Research and Development Center, 15 Khordad Educational Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran. anita.41724@gmail.com. FAU - Alijani, Sepideh AU - Alijani S AD - Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. FAU - Abaj, Faezeh AU - Abaj F AD - Department of Nutrition, Dietetics and Food, Faculty of Medicine, Nursing and Health Sciences, Monash University, Notting Hill, Australia. AD - Victorian Heart Institute, Victoria Heart Hospital, Clayton, VIC, Australia. FAU - Ebrahimian, Setayesh AU - Ebrahimian S AD - Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. AD - Student research committee, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260613 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Micronutrients) SB - IM MH - Humans MH - *Cleft Palate/epidemiology MH - *Cleft Lip/epidemiology MH - Iran/epidemiology MH - Cross-Sectional Studies MH - Female MH - *Food Insecurity MH - *Micronutrients MH - *Mothers MH - Infant MH - Adult MH - Infant, Newborn PMC - PMC13522343 OTO - NOTNLM OT - Cleft lip OT - Cleft palate OT - Dietary intake OT - Food insecurity OT - Orofacial clefts COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/06/15 11:34 MHDA- 2026/08/28 11:46 PMCR- 2026/06/13 CRDT- 2026/06/13 23:19 PHST- 2026/03/30 00:00 [received] PHST- 2026/06/10 00:00 [accepted] PHST- 2026/08/28 11:46 [medline] PHST- 2026/06/15 11:34 [pubmed] PHST- 2026/06/13 23:19 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 10.1038/s41598-026-57977-2 [pii] AID - 57977 [pii] AID - 10.1038/s41598-026-57977-2 [doi] PST - epublish SO - Sci Rep. 2026 Jun 13;16(1):27066. doi: 10.1038/s41598-026-57977-2. PMID- 42288024 OWN - NLM STAT- MEDLINE DCOM- 20260810 LR - 20260810 IS - 1532-3099 (Electronic) IS - 0266-6138 (Linking) VI - 161 DP - 2026 Oct TI - Psychometric properties of the paternal support scale for breastfeeding in the Iranian fathers population. PG - 104893 LID - S0266-6138(26)00197-X [pii] LID - 10.1016/j.midw.2026.104893 [doi] AB - PROBLEM: The support of fathers is a crucial factor for successful breastfeeding. However, there has been a lack of a validated tool to measure this in Iran, which has impeded targeted assessment and intervention. BACKGRUND: Breastfeeding provides essential health benefits for infants. Paternal support plays a significant role in its continuation, highlighting the importance of having a culturally adapted measurement instrument within the Iranian context. METHODS: This methodological study used a cross-sectional design and selected 460 Iranian fathers through multi‑stage cluster sampling (detailed in Methods). It examined the scale's face validity, content validity, construct validity, and reliability after translation and cultural adaptation. RESULTS: First, confirmatory factor analysis (CFA) on the original 21‑item unidimensional model showed poor fit (chi(2)/df = 10.95, CFI = 0.45, RMSEA = 0.20), indicating that the original structure was not appropriate for the Iranian population. Therefore, exploratory factor analysis (EFA) was conducted, following which two items were removed from the original 21-item Turkish scale. The final Persian version comprised 19 items loading on four dimensions: cooperation, empowerment, caring, and facilitation. EFA extracted these factors explaining 62.507% of the total variance, and Confirmatory Factor Analysis (CFA) confirmed the model's adequacy. The scale demonstrated strong internal consistency (Cronbach's alpha=0.89) and excellent test-retest reliability (ICC=0.95). DISCUSSION: The study has successfully culturally adapted the PSSB into Persian, resulting in a culturally relevant, multidimensional tool. The four identified dimensions capture the holistic nature of paternal support in breastfeeding, aligning with the Iranian family context. The strong psychometric properties confirm its robustness for application in similar urban, educated populations. CONCLUSION: In this sample of Iranian fathers from Ardabil, the Persian version of the Paternal Support Scale for Breastfeeding (PSSB) demonstrated strong psychometric properties. The 19‑item, four‑factor structure showed excellent internal consistency, test‑retest reliability, and convergent/discriminant validity. The scale shows promise for use in similar urban and educated populations, pending further validation in rural, less educated, and low‑income groups. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Dastafkan, Sakine AU - Dastafkan S AD - Pediatric Nursing Student, Department of Pediatric Nursing, School of Nursing and Midwifery, Ardabil University of Medical Science, Ardabil, Iran. Electronic address: sakinedastafkan409@gmail.com. FAU - Vosoghi, Nazila AU - Vosoghi N AD - Department of Pediatric Nursing, School of Nursing and Midwifery, Ardabil University of Medical Sciences, Ardabil, Iran. Electronic address: Vosoghi2015@yahoo.com. FAU - Belil, Fatemeh Ebrahimi AU - Belil FE AD - Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Ardabil University of Medical Sciences, Ardabil, Iran. Electronic address: sara.1381@yahoo.com. FAU - Shahmari, Mehraban AU - Shahmari M AD - Nursing, Department of Medical-Surgical Nursing, School of Nursing and Midwifery, Ardabil University of Medical Sciences, Ardabil, Iran. Electronic address: mehrabanshahmari@yahoo.com. LA - eng PT - Journal Article DEP - 20260607 PL - Scotland TA - Midwifery JT - Midwifery JID - 8510930 SB - IM MH - Humans MH - *Psychometrics/instrumentation/methods/standards MH - Iran MH - *Breast Feeding/psychology/methods MH - Male MH - Reproducibility of Results MH - Adult MH - *Fathers/psychology MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Factor Analysis, Statistical MH - *Social Support OTO - NOTNLM OT - Breastfeeding OT - Paternal support OT - Psychometric properties OT - Scale COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2026/06/15 11:33 MHDA- 2026/08/11 00:35 CRDT- 2026/06/13 18:08 PHST- 2025/12/13 00:00 [received] PHST- 2026/05/03 00:00 [revised] PHST- 2026/06/06 00:00 [accepted] PHST- 2026/08/11 00:35 [medline] PHST- 2026/06/15 11:33 [pubmed] PHST- 2026/06/13 18:08 [entrez] AID - S0266-6138(26)00197-X [pii] AID - 10.1016/j.midw.2026.104893 [doi] PST - ppublish SO - Midwifery. 2026 Oct;161:104893. doi: 10.1016/j.midw.2026.104893. Epub 2026 Jun 7. PMID- 42287854 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260901 IS - 1873-4898 (Electronic) IS - 1477-5131 (Linking) VI - 22 IP - 5 DP - 2026 Oct TI - Stretched penile length in boys with hypospadias: Population-based analysis using validated nomogram. PG - 106058 LID - S1477-5131(26)00337-2 [pii] LID - 10.1016/j.jpurol.2026.106058 [doi] AB - BACKGROUND: Hypospadias affects 1 in 200-300 male births. Parents are often concerned about penile adequacy beyond the urethral defect itself, yet few studies have systematically compared stretched penile length (SPL) in hypospadias against population-based reference standards. OBJECTIVE: To evaluate SPL distribution patterns in boys with Types I and II hypospadias and compare them with established normative data. METHODS: The authors studied 876 consecutive boys aged 1-14 years with unoperated Types I (distal) and II (mid-shaft) hypospadias. Two observers independently measured SPL using the validated SPLINT technique. The SPL measurements were compared against age-matched normative data from 1276 Indian children. Exact binomial probability tests were used for percentile distributions, chi-square tests for subtype comparisons and t-tests for mean deviations. RESULTS: The cohort included 479 Type I and 397 Type II cases. SPL distribution showed a marked leftward shift: 71% fell below the 50th percentile (expected 50%, p < 0.001) and 41.5% below the 25th percentile. Lower percentiles were overrepresented, 20.7% were below the 10th percentile and 20.8% in the 10th-25th range. Upper percentiles were depleted: only 7.4% in the 75th-90th range and 1.7% above the 90th percentile (all p < 0.001). Mean SPL was reduced by 6.8% (95% CI: -8.18 to -5.42%) in Type I and 7.5% (95% CI: -9.05 to -5.92%) in Type II. The two subtypes showed no significant distributional difference (chi(2) = 6.22, p = 0.18), suggesting that meatal position does not predict SPL reduction. CONCLUSIONS: Boys with distal and mid-shaft hypospadias show clinically meaningful SPL reduction that follows a continuous distribution rather than an all-or-none pattern. SPL reduction appears independent of meatal position. These findings support routine SPL assessment using population-specific references and can guide preoperative counselling. CI - Copyright (c) 2026 Journal of Pediatric Urology Company. Published by Elsevier Ltd. All rights reserved. FAU - Goel, Prabudh AU - Goel P AD - Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: drprabudhgoel@gmail.com. FAU - Choudhury, Prativa AU - Choudhury P AD - Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: prativachoudhury1998@gmail.com. FAU - Yadav, Devendra Kumar AU - Yadav DK AD - Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: drdevendra@hotmail.com. FAU - Kaur, Punit AU - Kaur P AD - Department of Biophysics & All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: punitkaur@aiims.edu. FAU - Singh, Harpreet AU - Singh H AD - Indian Council of Medical Research, New Delhi, India. Electronic address: hsingh@bmi.icmr.org.in. FAU - Mani, Kalaivani AU - Mani K AD - Department of Biostatistics, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: manikalaivani@gmail.com. FAU - Bajpai, Minu AU - Bajpai M AD - Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: bajpai2b@gmail.com. FAU - Agarwala, Sandeep AU - Agarwala S AD - Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi 110029, India. Electronic address: sandpagr@hotmail.com. LA - eng PT - Journal Article DEP - 20260603 PL - England TA - J Pediatr Urol JT - Journal of pediatric urology JID - 101233150 SB - IM MH - Humans MH - Male MH - *Hypospadias/surgery/pathology MH - *Penis/pathology MH - Child, Preschool MH - Infant MH - *Nomograms MH - Child MH - Adolescent MH - Reference Values MH - Organ Size MH - Retrospective Studies OTO - NOTNLM OT - Hypospadias OT - Nomogram OT - Pediatric Urology OT - Penile Anthropometry OT - SPLINT Technique OT - Stretched Penile Length EDAT- 2026/06/15 11:34 MHDA- 2026/09/01 05:41 CRDT- 2026/06/13 18:03 PHST- 2026/01/02 00:00 [received] PHST- 2026/05/25 00:00 [revised] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/09/01 05:41 [medline] PHST- 2026/06/15 11:34 [pubmed] PHST- 2026/06/13 18:03 [entrez] AID - S1477-5131(26)00337-2 [pii] AID - 10.1016/j.jpurol.2026.106058 [doi] PST - ppublish SO - J Pediatr Urol. 2026 Oct;22(5):106058. doi: 10.1016/j.jpurol.2026.106058. Epub 2026 Jun 3. PMID- 42287140 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 1748-2631 (Electronic) IS - 1748-2623 (Print) IS - 1748-2623 (Linking) VI - 21 IP - 1 DP - 2026 Dec 31 TI - Physical activity, sleep, dietary habits, and screen time in Bogota's children post-pandemic lockdown: a mixed-methods study. PG - 2683936 LID - 10.1080/17482631.2026.2683936 [doi] LID - 2683936 AB - PURPOSE: This study explored how Bogota's children reconfigured their post-lockdown routines as part of their lived experience after returning to in-person activities. METHODS: A mixed-methods design was applied to capture behavioral patterns and their meanings. Quantitatively, 217 children aged 8-12 years attending pediatric clinics (Oct 2022-Sep 2023) completed validated questionnaires assessing physical activity, sleep, diet, and screen exposure. Qualitatively, semi-structured interviews were conducted with 15 children selected through purposive sampling to deepen insight into their daily routines and perceptions. Quantitative data were analyzed descriptively and by sex, while thematic analysis of interviews provided contextual interpretation. Integration occurred through a narrative weaving approach. RESULTS: Quantitative findings indicated moderate physical activity (66% met >/= 3 days/week), widespread sleep disturbances (49.7%), recreational screen use (median= 6 hours/day), and poor dietary intake (>90% consumed fewer than two vegetable servings daily). Narratives revealed that play was often replaced by structured adult-imposed activities, screen time served as both emotional refuge and behavioral reward, and sleep was self-managed through distractions such as eating or watching TV. Children viewed these habits as normal despite feelings of fatigue, frustration, and a longing for autonomy. CONCLUSION: Children's post-lockdown routines reflect adaptation rather than behavioral lapses, requiring interventions focus on emotional regulation, time balance, quality rest, and active play (not merely a return to pre-pandemic norms). FAU - Castrellon-Vergara, Shirley AU - Castrellon-Vergara S AUID- ORCID: 0009-0002-2359-9282 AD - Programa de Especializacion en Pediatria - Facultad de Medicina, Fundacion Universitaria Sanitas, Bogota D.C., Colombia. FAU - Rueda-Alfonso, Blanca Nathalia AU - Rueda-Alfonso BN AUID- ORCID: 0000-0003-1976-5495 AD - Programa de Especializacion en Pediatria - Facultad de Medicina, Fundacion Universitaria Sanitas, Bogota D.C., Colombia. FAU - Palacios-Ariza, Maria Alejandra AU - Palacios-Ariza MA AUID- ORCID: 0000-0002-9795-0285 AD - Unidad de Investigacion, Fundacion Universitaria Sanitas, Bogota D.C., Colombia. FAU - Guevara-Santamaria, Fabian Ricardo AU - Guevara-Santamaria FR AUID- ORCID: 0000-0003-0993-745X AD - Versania Primera Infancia, Grupo Keralty, Bogota, D.C., Colombia. LA - eng PT - Journal Article DEP - 20260613 PL - United States TA - Int J Qual Stud Health Well-being JT - International journal of qualitative studies on health and well-being JID - 101256506 SB - IM MH - Humans MH - Child MH - Female MH - *Screen Time MH - Male MH - *Sleep MH - *COVID-19/epidemiology MH - *Exercise MH - *Feeding Behavior MH - Colombia/epidemiology MH - *Diet MH - Surveys and Questionnaires MH - SARS-CoV-2 MH - *Quarantine/psychology MH - Sleep Duration MH - Qualitative Research PMC - PMC13267027 OTO - NOTNLM OT - COVID-19 OT - Child health OT - dietary habits OT - lifestyle OT - physical activity OT - screen time OT - sleep COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/15 11:31 MHDA- 2026/06/15 11:32 PMCR- 2026/06/13 CRDT- 2026/06/13 07:03 PHST- 2026/06/15 11:32 [medline] PHST- 2026/06/15 11:31 [pubmed] PHST- 2026/06/13 07:03 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 2683936 [pii] AID - 10.1080/17482631.2026.2683936 [doi] PST - ppublish SO - Int J Qual Stud Health Well-being. 2026 Dec 31;21(1):2683936. doi: 10.1080/17482631.2026.2683936. Epub 2026 Jun 13. PMID- 42286760 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260621 LR - 20260813 IS - 1753-2000 (Print) IS - 1753-2000 (Electronic) IS - 1753-2000 (Linking) VI - 20 IP - 1 DP - 2026 Jun 13 TI - Feasibility and acceptability of a multi-level school-based intervention for adolescent mental health in Nepal: a mixed-methods study. LID - 10.1186/s13034-026-01111-7 [doi] LID - 86 AB - BACKGROUND: Adolescence is a crucial developmental stage characterized by rapid biological, psychological, and social changes, that increase vulnerability to mental health issues. Nearly half of all mental health conditions have their onset during this period and are influenced by individual, family, and environmental factors. Schools play a key role in promoting mental well-being among adolescents due to their accessibility and reach. While school-based mental health prevention interventions have shown positive outcomes in high-income countries, evidence from low- and middle-income countries (LMICs) is limited. This study aimed to assess the feasibility and acceptability of Health Action in Schools for a Thriving Adolescent Generation (HASHTAG), a comprehensive school-based intervention for adolescents aged 13-16 years in Nepal. METHODS: A feasibility cluster-randomized controlled trial was conducted in four secondary schools in Morang district, Nepal. Adolescents completed surveys at baseline and at a 3-month follow-up to evaluate mental well-being, emotional and behavioral outcomes, social support, school climate, and functioning. The intervention comprised two components: Thriving Environment in Schools (TES), implemented over three months and Thriving Together (TT), delivered through six weekly sessions. Quantitative data were collected electronically and analyzed descriptively. Qualitative data were gathered through focus group discussions and in-depth interviews with adolescents, teachers, and facilitators to explore implementation experiences and were analyzed thematically. RESULTS: Both the TES and TT components were well received, with TT sessions achieving an average attendance rate exceeding 70%, and being delivered as planned by trained facilitators, indicating good acceptability and feasibility. Explanatory analysis suggested a positive trend in anxiety outcomes in the intervention group while, social support showed a modest increase. Other outcomes showed small, non-significant changes. Qualitative findings highlighted perceived benefits such as improvements in school cleanliness, staff-student relationships, bullying and discrimination reduction, and positive social and behavioral changes. Participants found breathing exercises, games, the workbook, and the 'feeling box' particularly helpful. Implementation challenges included limited space, logistical constraints, COVID-19 related disruptions, and session length. CONCLUSION: HASHTAG demonstrated feasibility and accessibility as a school-based intervention for adolescents in Nepal, with preliminary indications of potential benefits. Addressing identified implementation challenges will be important for optimizing delivery in future studies. A fully powered randomized controlled trial is warranted to evaluate effectiveness. CI - (c) 2026. The Author(s). FAU - Luitel, Nagendra Prasad AU - Luitel NP AD - Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. nagendra.luitel@ki.se. AD - Research Department, Transcultural Psychosocial Organization Nepal (TPO Nepal), Baluwatar, Kathmandu, Nepal. nagendra.luitel@ki.se. AD - Center for Global Mental Health Equity, Department of Psychiatry and Behavioural Health, The George Washington University, Washington, DC, USA. nagendra.luitel@ki.se. FAU - Pradhan, Indira AU - Pradhan I AD - Research Department, Transcultural Psychosocial Organization Nepal (TPO Nepal), Baluwatar, Kathmandu, Nepal. FAU - Lamichhane, Bishnu AU - Lamichhane B AD - Research Department, Transcultural Psychosocial Organization Nepal (TPO Nepal), Baluwatar, Kathmandu, Nepal. FAU - Dulal, Nishan AU - Dulal N AD - Research Department, Transcultural Psychosocial Organization Nepal (TPO Nepal), Baluwatar, Kathmandu, Nepal. FAU - Melendez-Torres, G J AU - Melendez-Torres GJ AD - University of Exeter, Exeter, UK. FAU - Shi, Emily AU - Shi E AD - University of Illinois Chicago College of Medicine, Peoria, IL, USA. FAU - Dhillon, Malka AU - Dhillon M AD - Columbia University, Columbia, NY, USA. FAU - Gautam, Kamal AU - Gautam K AD - Research Department, Transcultural Psychosocial Organization Nepal (TPO Nepal), Baluwatar, Kathmandu, Nepal. AD - Center for Global Mental Health Equity, Department of Psychiatry and Behavioural Health, The George Washington University, Washington, DC, USA. FAU - Skeen, Sarah AU - Skeen S AD - Department of Global Health, Institute for Life Course Health Research, Stellenbosch University, Cape Town, South Africa. AD - Mental Health, Alcohol, Substance useand Tobacco Research Unit, South African Medical Research Council, Cape Town, South Africa. FAU - Tomlinson, Mark AU - Tomlinson M AD - Department of Global Health, Institute for Life Course Health Research, Stellenbosch University, Cape Town, South Africa. AD - School of Nursing and Midwifery, Queens University, Belfast, UK. FAU - Jordans, Mark J D AU - Jordans MJD AD - Research Department, Transcultural Psychosocial Organization Nepal (TPO Nepal), Baluwatar, Kathmandu, Nepal. AD - Health Service and Population Research Department, Centre for Global Mental Health, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. LA - eng GR - MR/ S02400X/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article DEP - 20260613 PL - England TA - Child Adolesc Psychiatry Ment Health JT - Child and adolescent psychiatry and mental health JID - 101297974 PMC - PMC13282874 OTO - NOTNLM OT - Depression and anxiety OT - Mental health promotion OT - Nepal OT - School climate OT - School-based COIS- Declarations. Ethics approval and consent to participate: This study was carried out in accordance with the Declaration of Helsinki and was granted ethical approval by the Nepal Health Research Council (NHRC) (Registration number: 342/2020P). Prior to participating in the study, each participant provided written informed consent. Only individuals who willingly agreed to take part were included in the study. Caregivers provided written consent and adolescents provided written assent before the study commenced. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/13 06:39 MHDA- 2026/06/13 06:40 PMCR- 2026/06/13 CRDT- 2026/06/13 00:12 PHST- 2026/01/21 00:00 [received] PHST- 2026/05/24 00:00 [accepted] PHST- 2026/06/13 06:40 [medline] PHST- 2026/06/13 06:39 [pubmed] PHST- 2026/06/13 00:12 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 10.1186/s13034-026-01111-7 [pii] AID - 1111 [pii] AID - 10.1186/s13034-026-01111-7 [doi] PST - epublish SO - Child Adolesc Psychiatry Ment Health. 2026 Jun 13;20(1):86. doi: 10.1186/s13034-026-01111-7. PMID- 42286440 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260925 IS - 2719-535X (Electronic) IS - 2719-6488 (Print) IS - 1428-345X (Linking) VI - 30 IP - 1 DP - 2026 Jan 1 TI - Comparative Performance of Machine Learning Models Using Food Intake Frequency Versus Vegetable Intake Data to Predict Problematic Mealtime Behaviour in Japanese Preschool Children. PG - 106-115 LID - 10.34763/jmotherandchild.20263001.d-25-00036 [doi] AB - BACKGROUND: Selective eating often leads to nutritional imbalance and mealtime stress, making early identification essential. OBJECTIVE: This study aimed to compare the predictive performance of machine learning (ML) models using two types of input data-namely, vegetable intake and food frequency questionnaire (FFQ) responses-to identify children with selective eating behaviour (cutoff score >/=1.59). MATERIAL AND METHODS: We analysed a cross-sectional dataset of 283 children aged 3-6 years using up to 8 predictors selected from 15 food-frequency items or 15 designated vegetables, along with age and sex. Selective eating behaviour was defined as a selective eating score of >/= 1.59. Eleven ML algorithms were trained and evaluated, resulting in 11,253 feature-model combinations. Model performance was assessed using 5-fold cross-validation based on accuracy, precision, recall, F1 score, and ROC-AUC. Permutation importance analysis was conducted to identify key predictive features. RESULTS: Among the 11 ML algorithms tested, vegetable intake-based L1 logistic regression showed the best performance (ROC-AUC = 0.717, accuracy = 0.647, precision = 0.722, recall = 0.659, F1 = 0.808). Permutation importance further identified tomato, green onion, and taro as key contributors in the vegetable intake-based L1 logistic regression model. In contrast, the FFQ-based Naive Bayes model showed relatively good discrimination (ROC-AUC = 0.619) despite moderate recall. CONCLUSION: Vegetable intake-based ML models were more effective than those using FFQ data in identifying children with selective eating behaviour. Detailed dietary assessment aids early detection. CI - (c) 2026 Naoki Sakane et al., published by Institute of Mother and Child. FAU - Sakane, Naoki AU - Sakane N AUID- ORCID: 0000-0002-2625-571X AD - Division of Preventive Medicine, Clinical Research Institute, National Hospital Organisation NHO Kyoto Medical Centre, Kyoto, Japan. FAU - Kawaguchi, Yaeko AU - Kawaguchi Y AD - Division of Preventive Medicine, Clinical Research Institute, National Hospital Organisation NHO Kyoto Medical Centre, Kyoto, Japan. FAU - Somei, Junichiro AU - Somei J AUID- ORCID: 0009-0007-0804-0831 AD - Division of Preventive Medicine, Clinical Research Institute, National Hospital Organisation NHO Kyoto Medical Centre, Kyoto, Japan. FAU - Suganuma, Akiko AU - Suganuma A AUID- ORCID: 0000-0002-2005-5151 AD - Division of Preventive Medicine, Clinical Research Institute, National Hospital Organisation NHO Kyoto Medical Centre, Kyoto, Japan. FAU - Domichi, Masayuki AU - Domichi M AUID- ORCID: 0000-0002-6157-8151 AD - Division of Preventive Medicine, Clinical Research Institute, National Hospital Organisation NHO Kyoto Medical Centre, Kyoto, Japan. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260608 PL - Poland TA - J Mother Child JT - Journal of mother and child JID - 101771247 RN - Japanese people SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - Classification Algorithms MH - Cross-Sectional Studies MH - East Asian People/psychology/statistics & numerical data MH - *Feeding Behavior/psychology MH - Japan MH - *Machine Learning MH - *Meals/psychology MH - Predictive Learning Models MH - Surveys and Questionnaires/statistics & numerical data MH - *Vegetables MH - Prediction Algorithms PMC - PMC13263313 OTO - NOTNLM OT - food OT - machine learning OT - machine performance OT - mealtime behaviour OT - preschool children OT - vegetable COIS- Conflicts of interest The authors declare that there are no conflicts of interest. EDAT- 2026/06/13 00:40 MHDA- 2026/06/13 06:38 PMCR- 2026/06/08 CRDT- 2026/06/12 23:53 PHST- 2025/09/10 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/06/13 06:38 [medline] PHST- 2026/06/13 00:40 [pubmed] PHST- 2026/06/12 23:53 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - jmotherandchild.20263001.d-25-00036 [pii] AID - 10.34763/jmotherandchild.20263001.d-25-00036 [doi] PST - epublish SO - J Mother Child. 2026 Jun 8;30(1):106-115. doi: 10.34763/jmotherandchild.20263001.d-25-00036. eCollection 2026 Jan 1. PMID- 42286347 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260821 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Jun 12 TI - Development and initial validation of the Mindful Eating Behaviour Scale for children and parents. LID - 10.1007/s40519-026-01881-1 [doi] LID - 75 AB - PURPOSE: This research aimed to address existing methodological limitations in research on mindful eating behaviours in children, to enhance future research in this area. This manuscript presents the development and the assessment of the validity and reliability of a Mindful Eating Behaviour Scale for children and parents across five studies. METHODS: Study 1 assessed the scale's content validity using ratings from experts in the field. Study 2 evaluated the internal consistency of the scales. Study 3 explored temporal stability using a test-retest design with a 2-week interval. Studies 4 and 5 examined the criterion-related validity of the scales. RESULTS: Study 1 demonstrated that the items reflected the definition of mindful eating behaviour and were suitable for children. Study 2 showed that the scale and the subscales, "sensory attention" and "non-judgemental awareness" demonstrated good internal consistency. Using exploratory factor analysis, the scale supported the presence of two factors, "sensory attention" and "non-judgemental awareness". Study 3 showed that the scale was a reliable measure over time. Studies 4 and 5 showed that the scales are suitable measures for mindful eating behaviour. The scales demonstrated correlations between mindfulness and other eating behaviours, but further research is required, as only limited associations were observed. CONCLUSIONS: The current research presents new psychometric scales for mindful eating in children. The studies show that the scale is valid and reliable. LEVEL OF EVIDENCE: No level of evidence: basic science. CI - (c) 2026. The Author(s). FAU - Dunsmore, Natasha AU - Dunsmore N AD - Department of Psychology, School of Health and Life Sciences, Birmingham City University, The Curzon Building, 4 Cardigan St, Birmingham, B4 7BD, UK. natasha.dunsmore@mail.bcu.ac.uk. FAU - Hussain, Misba AU - Hussain M AD - Department of Psychology, School of Health and Life Sciences, Birmingham City University, The Curzon Building, 4 Cardigan St, Birmingham, B4 7BD, UK. FAU - Giannou, Kyriaki AU - Giannou K AD - Department of Psychology, Faculty of Health and Life Sciences, De Montfort University, Leicester, UK. FAU - Mantzios, Michail AU - Mantzios M AD - Department of Psychology, School of Health and Life Sciences, Birmingham City University, The Curzon Building, 4 Cardigan St, Birmingham, B4 7BD, UK. LA - eng PT - Journal Article PT - Validation Study DEP - 20260612 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - *Feeding Behavior/psychology MH - *Mindfulness MH - Child MH - Reproducibility of Results MH - Psychometrics MH - *Parents/psychology MH - Female MH - Male MH - Surveys and Questionnaires MH - *Child Behavior/psychology PMC - PMC13486019 OTO - NOTNLM OT - Children OT - Children's eating behaviours OT - Eating behaviours OT - Mindful Eating Behaviour Scale OT - Mindful eating OT - Mindful eating behaviour COIS- Declarations. Ethical approval: Ethical approval was obtained by the host University's Ethical Committee corresponding ethical guidelines. Application approval number: Dunsmore/#13801/sub3/R(B)/2024/Dec/BLSS FAEC. Participants were presented with information sheets and consent forms, following specific instructions set in the guidelines of the British Psychological Society (BPS), where a designated consent page used checkboxes to allow participants to indicate that they have read and understood each statement and key aspects of the consent information before proceeding with the study. The BPS ethical guidelines were followed when collecting the research and specified the retention of data for 10 years in a secure institutional server, to which participants also provided consent. Consent to participate: Informed consent was obtained from all individual participants included in the study. Consent for publication: Informed consent was obtained from all individual participants to publish the findings of this research. Competing interests: The authors declare no competing interests. EDAT- 2026/06/13 00:39 MHDA- 2026/08/19 14:49 PMCR- 2026/06/12 CRDT- 2026/06/12 23:26 PHST- 2025/12/12 00:00 [received] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/08/19 14:49 [medline] PHST- 2026/06/13 00:39 [pubmed] PHST- 2026/06/12 23:26 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - 10.1007/s40519-026-01881-1 [pii] AID - 1881 [pii] AID - 10.1007/s40519-026-01881-1 [doi] PST - epublish SO - Eat Weight Disord. 2026 Jun 12;31(1):75. doi: 10.1007/s40519-026-01881-1. PMID- 42286317 OWN - NLM STAT- MEDLINE DCOM- 20260827 LR - 20260831 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Jun 13 TI - Development and validation of the Japanese version of Sociocultural Attitudes Towards Appearance Questionnaire-4-Revised (SATAQ-4R) among Japanese adolescents. LID - 10.1007/s40519-026-01877-x [doi] LID - 76 AB - PURPOSE: Internalization of appearance ideals and sociocultural pressures contribute to body dissatisfaction and eating disorders. Japanese adolescents report high levels of body dissatisfaction despite relatively low body mass index compared to peers in other countries, highlighting potential cultural influences. However, the Sociocultural Attitudes Towards Appearance Questionnaire-4-Revised (SATAQ-4R) has not been validated in Japan. This study aimed to develop a Japanese version of the SATAQ-4R and examine its psychometric properties among Japanese adolescents. METHODS: A nationwide population-based study was conducted in 2023 among 1,368 adolescents aged 11-17 years (girls: n = 694; boys: n = 674). Participants completed self-reported questionnaires. The factor structure of the SATAQ-4R was evaluated using exploratory and confirmatory factor analyses (EFA and CFA), internal consistency was assessed using Cronbach's alpha, and convergent validity was examined using eating-related measures. RESULTS: EFA suggested a five-factor 23-item structure for girls and a seven-factor 23-item structure for boys. CFA showed suboptimal fit for the female model and comparatively better fit for the male model. Most subscales showed acceptable internal consistency, although one female pressure-related subscale showed inadequate reliability. Correlations with external measures provided partial evidence of convergent validity, with associations varying by sex and subscale. CONCLUSION: These findings provide preliminary evidence for psychometric properties of the Japanese SATAQ-4R. However, suboptimal female model fit, inadequate reliability of one female subscale, and mixed convergent validity evidence indicate that the resulting Japanese models should be used with caution. LEVEL OF EVIDENCE: Level III, cross-sectional observational study. CI - (c) 2026. The Author(s). FAU - Saito, Takumi AU - Saito T AD - Center for Postgraduate Education and Training, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. AD - Department of Life Course Epidemiology, Integrated Center for Women's Health, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. FAU - Ishitsuka, Kazue AU - Ishitsuka K AD - Department of Life Course Epidemiology, Integrated Center for Women's Health, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. ishitsuka-k@ncchd.go.jp. FAU - Piedvache, Aurelie AU - Piedvache A AD - Department of Social Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. FAU - Yamaguchi, Satoshi AU - Yamaguchi S AD - Unit for Mental Health Promotion, Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan. FAU - Yamasaki, Syudo AU - Yamasaki S AD - Unit for Mental Health Promotion, Research Center for Social Science & Medicine, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan. FAU - Usami, Satoshi AU - Usami S AD - Graduate School of Education, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. FAU - Ishiguro, Akira AU - Ishiguro A AD - Department of Pediatrics, National Disaster Medical Center, 3256 Midoricho, Tachikawa, Tokyo, 190-0014, Japan. FAU - Morisaki, Naho AU - Morisaki N AD - Department of Social Medicine, National Center for Child Health and Development, 2-10-1 Okura, Setagaya-ku, Tokyo, 157-8535, Japan. LA - eng GR - 23K12759/Japan Society for the Promotion of Science/ GR - 22H03362/Japan Society for the Promotion of Science/ GR - JPCA24DA1234/Children and Families Agency Program/ GR - 2023B-13/The Grant of National Center for Child Health and Development/ GR - 2025A-3/The Grant of National Center for Child Health and Development/ GR - JPJSJRP20211709/JRP-LEAD with UKRI/ GR - 23FB1003/Health Labour Sciences Research Grants/ PT - Journal Article PT - Validation Study DEP - 20260613 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 RN - Japanese people SB - IM MH - Humans MH - Male MH - Adolescent MH - Female MH - Japan MH - Psychometrics MH - Child MH - *Body Image/psychology MH - Reproducibility of Results MH - Surveys and Questionnaires MH - *Attitude MH - Factor Analysis, Statistical MH - Body Satisfaction MH - *Body Dissatisfaction/psychology MH - East Asian People PMC - PMC13518460 OTO - NOTNLM OT - Adolescents OT - Body image OT - SATAQ-4R OT - Social media OT - Thin internalization OT - Validation COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki and the Ethical Guidelines for Clinical/Epidemiological Studies of the Japanese Ministry of Health, Labour, and Welfare. Ethical approval was obtained from the Ethics Committee of the National Center for Child Health, Japan (No. 2021-133). Consent to participate: Written informed consent was obtained from the participants and their guardians. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/13 00:40 MHDA- 2026/08/27 05:35 PMCR- 2026/06/13 CRDT- 2026/06/12 23:25 PHST- 2026/03/13 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/08/27 05:35 [medline] PHST- 2026/06/13 00:40 [pubmed] PHST- 2026/06/12 23:25 [entrez] PHST- 2026/06/13 00:00 [pmc-release] AID - 10.1007/s40519-026-01877-x [pii] AID - 1877 [pii] AID - 10.1007/s40519-026-01877-x [doi] PST - epublish SO - Eat Weight Disord. 2026 Jun 13;31(1):76. doi: 10.1007/s40519-026-01877-x. PMID- 42285845 OWN - NLM STAT- MEDLINE DCOM- 20260629 LR - 20260723 IS - 2212-1692 (Electronic) IS - 1875-9572 (Linking) VI - 67 IP - 4 DP - 2026 Jul TI - Pediatric post-acute sequelae of SARS-CoV-2 infection in Taiwan: Insights from the DISCOVER cohort. PG - 343-349 LID - S1875-9572(26)00072-0 [pii] LID - 10.1016/j.pedneo.2026.03.007 [doi] AB - The post-acute sequelae of SARS-CoV-2 infection (PASC), or long COVID, represent a multifaceted challenge in pediatric populations, characterized by symptoms persisting beyond the acute phase. In Taiwan, where early public health measures initially contained the pandemic, the 2022 Omicron surge prompted focused investigation into pediatric PASC, highlighting the critical need for longitudinal data in this specific demographic. To address this challenge, the Diagnosis and Support for COVID Children to Enhance Recovery (DISCOVER) study was established as a prospective, multidisciplinary cohort. By employing a multimodal approach, this study characterizes the clinical landscape of pediatric PASC in Taiwan through validated screening instruments, AI-driven diagnostics, and pulmonary assessments, while concurrently evaluating immune biomarkers, vaccination protection, and vitamin D intervention. This review synthesizes comprehensive findings from the cohort. While the acute phase of infection was predominantly mild, a substantial proportion of children experienced persistent multisystem symptoms, with fatigue, respiratory issues, and somatic complaints being most prevalent. Vaccination was found to significantly modify the disease trajectory, offering protection against subsequent gastrointestinal sequelae and preserving pulmonary function by mitigating small airway resistance. Furthermore, advanced diagnostic modalities, including impulse oscillometry and deep learning-assisted echocardiography, successfully unmasked subclinical organ dysfunction that conventional methods often failed to detect. Mechanistic investigations revealed that symptom severity was closely linked to elevated anti-nucleocapsid antibody titers, while markers of T-cell exhaustion evidenced persistent immune dysregulation, rather than ongoing viral replication. Notably, a preliminary single-center randomized controlled trial within this cohort provided early evidence that vitamin D supplementation may reduce the overall symptom burden and modulate pro-inflammatory cytokine profiles in children with PASC. Collectively, these findings underscore the multisystem nature and immune-driven mechanism of pediatric PASC, while highlighting the role of vaccination, advanced diagnostics, and targeted nutritional interventions in improving recovery. CLINICAL TRIAL REGISTRATION: NCT05426291 (ClinicalTrials.gov). CI - Copyright (c) 2026 Taiwan Pediatric Association. Published by Elsevier B.V. All rights reserved. FAU - Chen, Pei-Chi AU - Chen PC AD - Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. FAU - Hsu, Yu-Lung AU - Hsu YL AD - Department of Pediatrics Infectious Diseases, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404327, Taiwan. FAU - Wu, Lawrence Shih-Hsin AU - Wu LS AD - Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404327, Taiwan. FAU - Liu, Xiao-Ling AU - Liu XL AD - Center of Allergy, Immunology and Microbiome (A.I.M), China Medical University Hospital and Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FAU - Tsai, Hui-Ju AU - Tsai HJ AD - Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan; Department of Medical Science, National Tsing-Hua University, Hsinchu, Taiwan. FAU - Wang, Jiu-Yao AU - Wang JY AD - Department of Pediatrics Allergy, Immunology, and Rheumatology, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan; Center of Allergy, Immunology and Microbiome (A.I.M), China Medical University Hospital and Children's Hospital, China Medical University, Taichung, 404327, Taiwan; Department of Pediatrics Infectious Diseases, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. Electronic address: a122@mail.ncku.edu.tw. CN - DISCOVER Study Group LA - eng SI - ClinicalTrials.gov/NCT05426291 PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20260529 PL - Singapore TA - Pediatr Neonatol JT - Pediatrics and neonatology JID - 101484755 SB - IM MH - Humans MH - Taiwan/epidemiology MH - *COVID-19/complications/diagnosis/epidemiology MH - Post-Acute COVID-19 Syndrome MH - Child MH - Cohort Studies MH - SARS-CoV-2 OTO - NOTNLM OT - COVID-19 OT - Pediatrics OT - Post-acute sequelae of SARS-CoV-2 infection (PASC) OT - Vitamin D COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. FIR - Wei, Gi-Hong IR - Wei GH IRAD- Division of Medical Research, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Liu, Pan-Yuan IR - Liu PY IRAD- Division of Medical Research, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Hsieh, Kai-Sheng IR - Hsieh KS IRAD- Department of Pediatric Cardiology, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Lai, Huan-Cheng IR - Lai HC IRAD- Department of Pediatrics Infectious Diseases, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Lin, Chien-Heng IR - Lin CH IRAD- Division of Pediatric Pulmonology and Intensive Care, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Lin, Hsiao-Chuan IR - Lin HC IRAD- Department of Pediatrics Infectious Diseases, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Chen, An-Chyi IR - Chen AC IRAD- Division of Pediatric Gastroenterology, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Lin, Hung-Chih IR - Lin HC IRAD- Division of Neonatology, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Chou, I-Ching IR - Chou IC IRAD- Division of Pediatric Neurology, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Soong, Wen-Jue IR - Soong WJ IRAD- Division of Pediatric Pulmonology and Intensive Care, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Hwang, Kao-Pin IR - Hwang KP IRAD- Department of Pediatrics Infectious Diseases, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Lu, Henry Horng-Shing IR - Lu HH IRAD- Institute of Statistics, National Yang Ming Chiao Tung University, Hsinchu, Taiwan. FIR - Liu, Shu-Tsen IR - Liu ST IRAD- Department of Pediatric Psychiatry, China Medical University Children's Hospital, China Medical University, Taichung, 404327, Taiwan. FIR - Lin, Chung-Ying IR - Lin CY IRAD- Institute of Allied Health Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan; Biostatistics Consulting Center, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, 1 University Rd., Tainan, 701401, Taiwan; School of Nursing, College of Nursing, Kaohsiung Medical University, Kaohsiung, 807378, Taiwan. EDAT- 2026/06/13 00:39 MHDA- 2026/06/30 00:32 CRDT- 2026/06/12 21:58 PHST- 2025/12/10 00:00 [received] PHST- 2026/03/02 00:00 [revised] PHST- 2026/03/04 00:00 [accepted] PHST- 2026/06/30 00:32 [medline] PHST- 2026/06/13 00:39 [pubmed] PHST- 2026/06/12 21:58 [entrez] AID - S1875-9572(26)00072-0 [pii] AID - 10.1016/j.pedneo.2026.03.007 [doi] PST - ppublish SO - Pediatr Neonatol. 2026 Jul;67(4):343-349. doi: 10.1016/j.pedneo.2026.03.007. Epub 2026 May 29. PMID- 42285612 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 10 IP - 1 DP - 2026 Jun 12 TI - Smartphone-based support for early childhood development in a rural low-resource setting: an individually randomised pilot feasibility trial from Guatemala. LID - 10.1136/bmjpo-2025-003979 [doi] LID - e003979 AB - OBJECTIVE: To test the feasibility of a smartphone app, BebeApp, that provides evidence-based early childhood development (ECD) guidance in rural Guatemala and pilot procedures for an adequately powered randomised controlled trial. DESIGN: We conducted an individually randomised pilot feasibility trial to compare BebeApp to printed ECD guidance. SETTING: This trial was conducted in Tecpan, Chimaltenango, a semi-rural community that is 95% Kaqchikel Indigenous Maya. PATIENTS: First-time primary caregiver-infant (0-28 days) dyads. INTERVENTIONS: BebeApp provides age-dependent, evidence-based caregiver guidance for breastfeeding and complementary feeding, sleep and developmental support. MAIN OUTCOME MEASURES: A mixed-methods evaluation of BebeApp's implementation and acceptability using the Reach, Effectiveness, Adoption, Implementation, Maintenance framework. App usability, usefulness and satisfaction were assessed via questionnaires, semi-structured interviews and app interaction data. RESULTS: 41 infant-caregiver dyads were enrolled with 40 completing the study. Engagement was high with caregivers opening BebeApp a median (IQR) 11 (6-21) times per month. Usability was found to be acceptable but no difference was found between pre-measurements and post-measurements. In interviews, caregivers expressed some initial difficulty using BebeApp but were able to gain confidence with a training session. App usefulness and satisfaction responses were positive. Caregivers often noted that BebeApp was their only source of ECD information outside of their family. CONCLUSIONS: We found that caregivers in rural Guatemala responded positively to a smartphone ECD app and engaged with it throughout the trial. Given the urgent need for ECD programmes in low- and middle-income settings, smartphone apps may be a method to deliver services directly to caregivers. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Tschida, Scott AU - Tschida S AUID- ORCID: 0000-0002-1821-6702 AD - Center for Indigenous Health Research, Maya Health Alliance, Guatemala, Chimaltenango Department, Guatemala scott.tschida@wuqukawoq.org. FAU - Tuiz, Eva Leticia AU - Tuiz EL AUID- ORCID: 0009-0005-4995-8273 AD - Center for Indigenous Health Research, Maya Health Alliance, Guatemala, Chimaltenango Department, Guatemala. FAU - Lopez, Duglas AU - Lopez D AUID- ORCID: 0009-0008-9117-3228 AD - Center for Indigenous Health Research, Maya Health Alliance, Guatemala, Chimaltenango Department, Guatemala. FAU - Canu, Meylin AU - Canu M AD - Center for Indigenous Health Research, Maya Health Alliance, Guatemala, Chimaltenango Department, Guatemala. FAU - Boron, Vilma AU - Boron V AUID- ORCID: 0009-0003-2862-2848 AD - Center for Indigenous Health Research, Maya Health Alliance, Guatemala, Chimaltenango Department, Guatemala. FAU - Zarazua, Javier AU - Zarazua J AUID- ORCID: 0009-0008-8813-1529 AD - Proyecto Aigle Guatemala, Guatemala City, Guatemala Department, Guatemala. FAU - Grazioso, Maria Del Pilar AU - Grazioso MDP AD - Proyecto Aigle Guatemala, Guatemala City, Guatemala Department, Guatemala. FAU - Smith, Beth A AU - Smith BA AUID- ORCID: 0000-0003-2531-5394 AD - Developmental Neuroscience and Neurogenetics Program, Children's Hospital Los Angeles, The Saban Research Institute, Los Angeles, California, USA. AD - Division of Developmental-Behavioral Pediatrics, Children's Hospital Los Angeles, Los Angeles, California, USA. AD - Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA. FAU - Rohloff, Peter AU - Rohloff P AUID- ORCID: 0000-0001-7274-8315 AD - Center for Indigenous Health Research, Maya Health Alliance, Guatemala, Chimaltenango Department, Guatemala. AD - Division of Global Health Equity, Brigham and Women's Hospital, Boston, Massachusetts, USA. AD - Department of Global Health and Social Medicine, Harvard Medical School, Boston, Massachusetts, USA. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260612 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Guatemala MH - Pilot Projects MH - *Smartphone MH - Infant MH - Feasibility Studies MH - Female MH - Male MH - Rural Population MH - *Child Development MH - *Mobile Applications MH - Infant, Newborn MH - Resource-Limited Settings MH - Breast Feeding MH - Caregivers/education PMC - PMC13289361 OTO - NOTNLM OT - Child Health OT - Information Technology OT - Low and Middle Income Countries OT - Qualitative research OT - Technology EDAT- 2026/06/13 00:39 MHDA- 2026/06/13 00:40 PMCR- 2026/06/12 CRDT- 2026/06/12 21:03 PHST- 2025/08/15 00:00 [received] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/13 00:40 [medline] PHST- 2026/06/13 00:39 [pubmed] PHST- 2026/06/12 21:03 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - 10.1136/bmjpo-2025-003979 [pii] AID - bmjpo-2025-003979 [pii] AID - 10.1136/bmjpo-2025-003979 [doi] PST - epublish SO - BMJ Paediatr Open. 2026 Jun 12;10(1):e003979. doi: 10.1136/bmjpo-2025-003979. PMID- 42285572 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 6 DP - 2026 Jun 12 TI - Association of 24-hour movement guideline adherence with mental health symptoms among Colombian university students: a cross-sectional study. PG - e118611 LID - 10.1136/bmjopen-2026-118611 [doi] LID - e118611 AB - OBJECTIVE: This study aimed to determine the associations between adherence to the 24-hour movement guidelines and symptoms of anxiety and depression among Colombian university students. STUDY DESIGN: Cross-sectional study. PARTICIPANTS: 1125 individuals (mean age 20.2+/-2.5 years; 56.7% female). SETTING: Students sampled from a single public university. PRIMARY AND SECONDARY OUTCOME MEASURES: Participants completed validated self-report instruments: the International Physical Activity Questionnaire-Short Form to assess physical activity (PA), sedentary behaviour (SB) and the Pittsburgh Sleep Quality Index to assess sleep duration. Symptoms of depression and anxiety were measured using the Hospital Anxiety and Depression Scale, with a score of >/=11 used to classify elevated symptoms. Binary logistic regression models were used to estimate associations between adherence to the 24-hour movement guidelines (meeting all three, two, one or none) and mental health outcomes, adjusting for potential confounders. RESULTS: Only 15.5% of students met all three components of the 24-hour movement guidelines. Meeting a greater number of components was significantly associated with lower odds of depressive and anxiety symptoms. In fully adjusted analyses, students who met all three guidelines were less likely to report anxiety symptoms (OR=0.26; 95%CI 0.13 to 0.54) and depressive symptoms (OR=0.42; 95%CI 0.22 to 0.79) compared with those who met none. Among individual behaviours, sufficient PA and adequate sleep were independently associated with lower odds of both outcomes, whereas high SB was associated with higher odds of elevated symptoms. CONCLUSIONS: In this cross-sectional study, adherence to a greater number of 24-hour movement guideline components was associated with lower levels of anxiety and depressive symptoms in a graded manner. However, the cross-sectional design precludes inference regarding directionality or causality, and bidirectional associations or residual confounding remain possible. Longitudinal and interventional studies are needed to determine whether integrated daily movement behaviours influence mental health outcomes in young adults, particularly in Latin American populations. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Romero-Martinez, Gonzalo AU - Romero-Martinez G AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Urriago-Fontal, Juan Carlos AU - Urriago-Fontal JC AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Quirama-Garcia, Hector Mario AU - Quirama-Garcia HM AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Ortiz-Lopez, Julian David AU - Ortiz-Lopez JD AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Arias-Alzate, Carolina AU - Arias-Alzate C AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Gutierrez-Quintero, Gustavo Adolfo AU - Gutierrez-Quintero GA AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Palma Pulido, Luis Hebert AU - Palma Pulido LH AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Calderon-Gonzalez, Juan Carlos AU - Calderon-Gonzalez JC AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia. FAU - Ramirez-Velez, Robinson AU - Ramirez-Velez R AUID- ORCID: 0000-0003-3075-6960 AD - Facultad de Ciencias de la Educacion, Unidad Central del Valle del Cauca (UCEVA), Tulua, Colombia robin640@hotmail.com robinson.ramirez@unavarra.es. AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Universidad Publica de Navarra (UPNA), Pamplona, Spain. AD - CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain. LA - eng PT - Journal Article DEP - 20260612 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Colombia/epidemiology MH - Young Adult MH - *Students/psychology MH - *Depression/epidemiology/prevention & control MH - *Anxiety/epidemiology/prevention & control MH - Male MH - *Exercise/psychology MH - Universities MH - *Guideline Adherence MH - Sedentary Behavior MH - *Mental Health MH - Sleep Duration MH - Adult MH - Adolescent MH - Logistic Models MH - Surveys and Questionnaires MH - Self Report PMC - PMC13289006 OTO - NOTNLM OT - Anxiety disorders OT - Depression & mood disorders OT - Exercise OT - Health OT - SLEEP MEDICINE OT - Young Adult COIS- Competing interests: None declared. EDAT- 2026/06/13 00:38 MHDA- 2026/06/13 06:38 PMCR- 2026/06/12 CRDT- 2026/06/12 20:43 PHST- 2026/06/13 06:38 [medline] PHST- 2026/06/13 00:38 [pubmed] PHST- 2026/06/12 20:43 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - bmjopen-2026-118611 [pii] AID - 10.1136/bmjopen-2026-118611 [doi] PST - epublish SO - BMJ Open. 2026 Jun 12;16(6):e118611. doi: 10.1136/bmjopen-2026-118611. PMID- 42285221 OWN - NLM STAT- MEDLINE DCOM- 20260923 LR - 20260929 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 75 DP - 2026 Oct TI - Nutritional intake in children with cerebral palsy and typically developing peers: A comprehensive study using a novel smartphone application. PG - 103401 LID - S2405-4577(26)00498-5 [pii] LID - 10.1016/j.clnesp.2026.103401 [doi] AB - BACKGROUND & AIMS: Nutrition might play a key role in addressing structural alterations in children with cerebral palsy (CP). However, a comprehensive description of their nutritional intake, and comparison to typically developing (TD) peers, using a low-burden assessment method, is lacking. The aim was to (1) propose a novel smartphone application to register nutritional intake; (2) comprehensively describe nutritional intake in children with CP in comparison to the nutritional guidelines; and (3) in comparison to TD peers. METHODS: A prospective cross-sectional observational study was conducted in ambulant children with spastic CP and TD peers. Nutritional intake was assessed using a 3-day estimated food record, logged in a novel smartphone application 'Digital Diary'. The intra-rater inter-session reliability of the Digital Diary was analyzed using the Intraclass Correlation Coefficient (ICC) and Standard Error of Measurements (SEM). The independent t-test investigated differences between the total samples of children with CP and TD children, and between the different age and CP-severity groups. RESULTS: Fifty-five children with spastic CP (6.51 +/- 3.10 years) and 50 TD children (7.26 +/- 2.85 years) were included. ICC varied from poor to good reliability, depending on the nutritional parameter. All children with CP and TD children met the daily protein intake guideline, but only half had a sufficient daily energy intake. This insufficient energy intake was not mirrored in their weight-for-height standard deviations. No significant differences (p > 0.05) exceeding the calculated SEM values were present between different CP-severity levels or between TD children and children with CP. CONCLUSIONS: The Digital Diary offers a time-efficient way to record nutritional intake. Although its test-retest reliability varied, key SEM values were reported to support more accurate interpretation. This study underscores the need to investigate the basal metabolic rate and overall energy requirements of children with CP in order to develop accurate, population-specific nutritional guidelines. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Verreydt, Ineke AU - Verreydt I AD - Department of Rehabilitation Sciences, KU Leuven, Belgium. Electronic address: ineke.verreydt@kuleuven.be. FAU - Rymen, Daisy AU - Rymen D AD - Department of Development and Regeneration, Faculty of Medicine, KU Leuven, Belgium. FAU - Staut, Lauraine AU - Staut L AD - Department of Rehabilitation Sciences, KU Leuven, Belgium; Clinical Motion Analysis Laboratory, University Hospitals Leuven, Belgium. FAU - Vanhauwaert, Erika AU - Vanhauwaert E AD - University Colleges Leuven-Limburg (UCLL), Centre of Expertise Health Innovation, Leuven, Belgium. FAU - Maes, Gitte AU - Maes G AD - Department of Rehabilitation Sciences, KU Leuven, Belgium. FAU - Lambrechts, Charlotte AU - Lambrechts C AD - Department of Rehabilitation Sciences, KU Leuven, Belgium. FAU - Campenhout, Anja Van AU - Campenhout AV AD - Department of Development and Regeneration, Faculty of Medicine, KU Leuven, Belgium; Pediatric Orthopedics, Department of Orthopedics, University Hospitals Leuven, Belgium. FAU - Desloovere, Kaat AU - Desloovere K AD - Department of Rehabilitation Sciences, KU Leuven, Belgium; Clinical Motion Analysis Laboratory, University Hospitals Leuven, Belgium. FAU - Ortibus, Els AU - Ortibus E AD - Department of Development and Regeneration, Faculty of Medicine, KU Leuven, Belgium; Leuven Child and Youth Institute, KU Leuven, Belgium. LA - eng PT - Journal Article PT - Observational Study DEP - 20260612 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology MH - Child MH - Female MH - Cross-Sectional Studies MH - *Smartphone MH - Prospective Studies MH - Male MH - Reproducibility of Results MH - Diet Records MH - *Mobile Applications MH - *Nutrition Assessment MH - Energy Intake MH - *Nutritional Status MH - Child, Preschool OTO - NOTNLM OT - Cerebral palsy OT - Dietary OT - Digital diary OT - Macronutrients OT - Nutrition OT - Typically developing COIS- Conflicts of interest The authors declare no conflict of interest. EDAT- 2026/06/13 00:38 MHDA- 2026/09/23 05:35 CRDT- 2026/06/12 19:32 PHST- 2026/01/27 00:00 [received] PHST- 2026/06/01 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/09/23 05:35 [medline] PHST- 2026/06/13 00:38 [pubmed] PHST- 2026/06/12 19:32 [entrez] AID - S2405-4577(26)00498-5 [pii] AID - 10.1016/j.clnesp.2026.103401 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2026 Oct;75:103401. doi: 10.1016/j.clnesp.2026.103401. Epub 2026 Jun 12. PMID- 42285031 OWN - NLM STAT- MEDLINE DCOM- 20260810 LR - 20260810 IS - 1532-3099 (Electronic) IS - 0266-6138 (Linking) VI - 161 DP - 2026 Oct TI - Strengthening breastfeeding with fatherly care: Transcultural validation of the Chinese version of the Paternal Support Scale for Breastfeeding (PSSB-C). PG - 104891 LID - S0266-6138(26)00195-6 [pii] LID - 10.1016/j.midw.2026.104891 [doi] AB - BACKGROUND: Fathers play a significant role in breastfeeding by providing emotional, informational, and practical support. However, few validated instruments assess fathers' self-perceived supportive behaviors. The Paternal Support Scale for Breastfeeding (PSSB) evaluates paternal support in breastfeeding settings. This study examines the reliability and validity of the Chinese version (PSSB-C) and explores links between paternal characteristics and support levels. METHODS: The PSSB was translated and adapted using an enhanced Brislin model. A convenience sample of 301 fathers was recruited from pediatric clinics in a tertiary hospital in Fujian, China. Participants completed a general questionnaire and the PSSB-C. The total sample was randomly split into two: Sample 1 (n = 151) for an Exploratory Factor Analysis (EFA) and Sample 2 (n = 150) for a Confirmatory Factor Analysis (CFA). Descriptive statistics, internal consistency, reliability, and regression of the PSSB-C scores were conducted using the total sample. The reliability of the instrument was verified using Cronbach's alpha and the intraclass correlation coefficient (ICC). RESULTS: The final PSSB-C comprised 18 items and had a one-factor structure. Internal consistency was high (Cronbach's alpha = 0.976; ICC = 0.813). The EFA accounted for 71.0% of the variance, and the CFA confirmed a good model fit with factor loadings ranged from 0.77 to 0.87. Item content validity index (I-CVI) ranging from 0.83 to 1.00. The PSSB-C scores were significantly different by father's age, infant's age, and place of residence (p < 0.05). CONCLUSIONS: The findings indicate that the 18-item PSSB-C reliably measures fathers' self-perceived supportive behaviors in breastfeeding. Using this scale in clinical settings can help identify fathers who provide inadequate support, guide personalized interventions, and encourage sustained breastfeeding, thereby improving health outcomes for mothers and infants. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Fu, Jie AU - Fu J AD - School of Nursing, Fujian Medical University, Fuzhou 350122, China. Electronic address: fujie0628@163.com. FAU - Zhang, Kun AU - Zhang K AD - School of Nursing, Shanxi Medical University, Taiyuan 030001, China. Electronic address: 17860487212@163.com. FAU - Liu, Fangyi AU - Liu F AD - School of Nursing, Fujian Medical University, Fuzhou 350122, China. Electronic address: fangyiliu2000@163.com. FAU - Zhang, Xueling AU - Zhang X AD - Department of Obstetrics and Gynecology Clinic, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China. Electronic address: zxl6120@163.com. FAU - Zeng, Yuxuan AU - Zeng Y AD - School of Nursing, Fujian Medical University, Fuzhou 350122, China. Electronic address: zzzyyxx02@163.com. FAU - Qin, Yaling AU - Qin Y AD - School of Nursing, Fujian Medical University, Fuzhou 350122, China. Electronic address: Yaling_Qin0202@163.com. FAU - Wang, Qiaosong AU - Wang Q AD - School of Medicine, Tongji University, Shanghai 200092, China. Electronic address: WQS1765790647@163.com. FAU - Lin, Rongjin AU - Lin R AD - School of Nursing, Fujian Medical University, Fuzhou 350122, China; Department of Nursing, the First Affiliated Hospital, Fujian Medical University, Fuzhou 350005, China. Electronic address: nplrj@126.com. LA - eng PT - Journal Article DEP - 20260607 PL - Scotland TA - Midwifery JT - Midwifery JID - 8510930 SB - IM MH - Humans MH - *Breast Feeding/psychology/methods MH - Male MH - *Psychometrics/instrumentation/methods/standards MH - China MH - Surveys and Questionnaires MH - Reproducibility of Results MH - Adult MH - *Fathers/psychology MH - Translating MH - Social Support OTO - NOTNLM OT - Breastfeeding OT - Paternal support OT - Psychometrics OT - Translation OT - Validation COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/13 00:39 MHDA- 2026/08/11 00:35 CRDT- 2026/06/12 18:10 PHST- 2025/11/19 00:00 [received] PHST- 2026/05/13 00:00 [revised] PHST- 2026/06/06 00:00 [accepted] PHST- 2026/08/11 00:35 [medline] PHST- 2026/06/13 00:39 [pubmed] PHST- 2026/06/12 18:10 [entrez] AID - S0266-6138(26)00195-6 [pii] AID - 10.1016/j.midw.2026.104891 [doi] PST - ppublish SO - Midwifery. 2026 Oct;161:104891. doi: 10.1016/j.midw.2026.104891. Epub 2026 Jun 7. PMID- 42284454 OWN - NLM STAT- Publisher LR - 20260612 IS - 1537-6613 (Electronic) IS - 0022-1899 (Linking) DP - 2026 Jun 12 TI - Induction of beta-Defensin 1 (DEFB1) via synthetic mRNA reduces Cryptosporidium parvum infection in human intestinal cells. LID - jiag302 [pii] LID - 10.1093/infdis/jiag302 [doi] AB - BACKGROUND: Cryptosporidiosis, caused by the protozoan parasite Cryptosporidium, is a leading cause of severe diarrhea, morbidity, and mortality in immunocompromised patients and malnourished children. Because the only FDA-approved treatment, nitazoxanide, shows limited efficacy in malnourished children and is ineffective in the immunodeficient, novel therapeutics for vulnerable populations are urgently needed. Host-directed therapy (HDT) is a promising strategy that utilizes the induction of endogenous protective molecules. For example, intestinal epithelial cells defend the mucosa by upregulating antimicrobial peptides like beta-defensins (DEFBs). Previous work has demonstrated that human DEFB1 possesses anti-cryptosporidial activity. In this work we used synthetic DEFB1-mRNA to induce DEFB1 protein in human intestinal cells and evaluate its protection against Cryptosporidium parvum infection in vitro. METHODS: HCT-8 cells were transfected with synthetic, co-transcriptionally capped DEFB1-mRNA or control mRNAs complexed with Lipofectamine MessengerMAX. Transfection efficiency was validated via EGFP expression. Twenty-four hours post-transfection, cells were challenged with excysted C. parvum sporozoites. DEFB1 protein induction was quantified by ELISA, while parasite burden and cell viability were assessed via microscopy, RT-qPCR, and MTT assays. RESULTS: Our results show that transfecting HCT-8 cells with synthetic mRNA results in a twofold increase in DEFB1 protein expression. This induction protects cells from C. parvum infection, achieving an approximate 80% reduction in parasite burden with no detectable cytotoxicity. CONCLUSIONS: These findings highlight the potential of mRNA technology for developing HDTs against cryptosporidiosis and other enteric pathogens. Moreover, this study establishes a foundation for utilizing synthetic mRNA as a rapid platform to evaluate intestinal gene function during parasitic infections. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Infectious Diseases Society of America. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Ortega-Mendez, Justine AU - Ortega-Mendez J AUID- ORCID: 0009-0008-4642-8914 AD - Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA. AD - Department of Internal Medicine-Division of Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA. FAU - Rojas, Jose M AU - Rojas JM AD - Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA. FAU - White, A Clinton Jr AU - White AC Jr AUID- ORCID: 0000-0002-9668-4632 AD - Department of Internal Medicine-Division of Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA. AD - Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas, USA. FAU - Castellanos-Gonzalez, Alejandro AU - Castellanos-Gonzalez A AUID- ORCID: 0000-0001-9092-153X AD - Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA. AD - Department of Internal Medicine-Division of Infectious Diseases, University of Texas Medical Branch, Galveston, Texas, USA. AD - Center for Tropical Diseases, University of Texas Medical Branch, Galveston, Texas, USA. LA - eng PT - Journal Article DEP - 20260612 PL - United States TA - J Infect Dis JT - The Journal of infectious diseases JID - 0413675 SB - IM OTO - NOTNLM OT - Cryptosporidium parvum OT - Cryptosporidiosis OT - DEFB1 OT - HCT-8 cells OT - Host-directed therapy OT - RNA therapeutics OT - Synthetic mRNA OT - antimicrobial peptides OT - beta-defensin 1 EDAT- 2026/06/12 18:41 MHDA- 2026/06/12 18:41 CRDT- 2026/06/12 14:42 PHST- 2026/02/16 00:00 [received] PHST- 2026/06/02 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/06/12 18:41 [medline] PHST- 2026/06/12 18:41 [pubmed] PHST- 2026/06/12 14:42 [entrez] AID - 8707192 [pii] AID - 10.1093/infdis/jiag302 [doi] PST - aheadofprint SO - J Infect Dis. 2026 Jun 12:jiag302. doi: 10.1093/infdis/jiag302. PMID- 42282294 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 0973-2063 (Print) IS - 0973-2063 (Electronic) IS - 0973-2063 (Linking) VI - 22 IP - 4 DP - 2026 TI - Weight-for-age and mid-upper arm circumference versus weight-for-length as severe acute malnutrition indicators: A validation study in under-6-month infants. PG - 2305-2309 LID - 10.6026/973206300222305 [doi] AB - Infants are more susceptible to malnutrition than older children. The prevalence of severe wasting among Indian infants under-6 months of age is 14.8% according to the National Family Health Survey-4. The myth of complete protection by exclusive breastfeeding is debated when the prevalence of severe acute malnutrition (SAM) sprang up as high as 23.8% in a cross sectional study from Central India among 600 infants. Area under the curve for MUAC <11 cm was 0.936 (95% confidence interval); its sensitivity and specificity were 69.23% and 73.09%, respectively; area under the curve for weight-for-age had higher sensitivity at (88.81%), but lower specificity (61.1%). The highlighted modifiable risk factors were low birth weight and adverse feeding practices. Combined MUAC and weight-for-length screening strategies should be used specifically in low-resource, community-based contexts for SAM in infants aged under six months. CI - (c) 2026 Biomedical Informatics. FAU - Pinky, Kumari AU - Pinky K AD - Department of Paediatrics, Government Medical College, Satna, Madhya Pradesh, India. FAU - Mahore, Rashmi Randa AU - Mahore RR AD - Department of Pediatrics, GMC Bhopal, Madhya Pradesh, India. FAU - Thakur, Shiva Saloni AU - Thakur SS AD - Department of Pediatrics, Civil hospital Amarwara, Chhindwara, Madhya Pradesh, India. FAU - Parmar, Sachin AU - Parmar S AD - Department of Community Medicine, V.K.S. Government Medical College, Neemuch, India. LA - eng PT - Journal Article DEP - 20260430 PL - Singapore TA - Bioinformation JT - Bioinformation JID - 101258255 PMC - PMC13252213 OTO - NOTNLM OT - Severe acute malnutrition (SAM) OT - infants under six months OT - mid-upper arm circumference (MUAC) EDAT- 2026/06/12 06:38 MHDA- 2026/06/12 06:39 PMCR- 2026/04/30 CRDT- 2026/06/12 05:02 PHST- 2026/04/01 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/06/12 06:39 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 05:02 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - 973206300222305 [pii] AID - 10.6026/973206300222305 [doi] PST - epublish SO - Bioinformation. 2026 Apr 30;22(4):2305-2309. doi: 10.6026/973206300222305. eCollection 2026. PMID- 42281579 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 6 DP - 2026 Jun TI - Dietary Index for Gut Microbiota and the Odds of Metabolic Dysfunction-Associated Fatty Liver Disease in Overweight and Obese Children and Adolescents: A Cross-Sectional Study. PG - e72640 LID - 10.1002/hsr2.72640 [doi] LID - e72640 AB - BACKGROUND AND AIMS: Metabolic dysfunction-associated fatty liver disease (MAFLD) is increasingly prevalent among children and adolescents with overweight or obesity, posing a growing public health challenge. Emerging evidence highlights the gut microbiota as a critical mediator in MAFLD pathogenesis, yet few studies have explored dietary factors influencing this axis in pediatric populations. This cross-sectional study investigated the association between the Dietary Index for Gut Microbiota (DI-GM) and MAFLD. METHODS: A total of 505 Iranian youths aged 7-18 years enrolled in a national obesity registry. Dietary intake was assessed via a validated 147-item Food Frequency Questionnaire. MAFLD was diagnosed according to international expert consensus, requiring ultrasound‑confirmed hepatic steatosis in the presence of overweight/obesity or other metabolic abnormalities. RESULTS: Multivariable logistic regression models revealed that higher DI-GM scores were significantly associated with lower odds of MAFLD (OR per unit increase: 0.80, 95% CI: 0.71-0.91; p < 0.001). Participants in the highest DI-GM quartile had markedly reduced risk compared to the lowest quartile (OR: 0.42, 95% CI: 0.22-0.81). Notably, the inverse association was significant only among post-pubertal participants. Mediation analysis indicated that liver enzymes-alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), and aspartate aminotransferase (AST)-partially explained this relationship, accounting for 20.0%, 19.2%, and 6.7% of the association, respectively. CONCLUSION: These findings underscore the potential of microbiota-oriented dietary strategies to mitigate MAFLD risk in pediatric populations with obesity. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Kamrani, Farzam AU - Kamrani F AUID- ORCID: 0009-0001-2460-4218 AD - Department of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran. FAU - Nikparast, Ali AU - Nikparast A AUID- ORCID: 0000-0003-2686-2584 AD - Student Research Committee, Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition & Food Technology Research Institute Shahid Beheshti University of Medical Sciences Tehran Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology Shahid Beheshti University of Medical Sciences Tehran Iran. FAU - Tabatabaeyan, Ali AU - Tabatabaeyan A AUID- ORCID: 0009-0005-9974-3537 AD - Department of Clinical Nutrition, School of Nutrition and Food Science, Nutrition and Food Security Research Center, Students' Research Committee Isfahan University of Medical Sciences Isfahan Iran. FAU - Etesami, Elahe AU - Etesami E AD - Department of Nutrition SR.C., Islamic Azad University Tehran Iran. FAU - Rohani, Pejman AU - Rohani P AD - Pediatric Gastroenterology and Hepatology Research Center, Pediatrics Center of Excellence, Children's Medical Center Tehran University of Medical Sciences Tehran Iran. FAU - Asghari, Golaleh AU - Asghari G AUID- ORCID: 0000-0002-7925-5158 AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology Shahid Beheshti University of Medical Sciences Tehran Iran. LA - eng PT - Journal Article DEP - 20260610 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13250465 OTO - NOTNLM OT - Dietary Index for Gut Microbiota OT - MAFLD OT - adolescent OT - children OT - metabolic dysfunction-associated fatty liver disease COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/12 06:40 PMCR- 2026/06/10 CRDT- 2026/06/12 04:54 PHST- 2025/10/10 00:00 [received] PHST- 2026/03/30 00:00 [revised] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/06/12 06:40 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 04:54 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - HSR272640 [pii] AID - 10.1002/hsr2.72640 [doi] PST - epublish SO - Health Sci Rep. 2026 Jun 10;9(6):e72640. doi: 10.1002/hsr2.72640. eCollection 2026 Jun. PMID- 42281577 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 6 DP - 2026 Jun TI - Household Water and Sanitation Practices and Their Association With Diarrheal and Acute Respiratory Infections Among Children Under Five in Ghana: A Cross-Sectional Predictive Model and Spatial Analysis. PG - e72628 LID - 10.1002/hsr2.72628 [doi] LID - e72628 AB - BACKGROUND AND AIMS: Diarrhea and acute respiratory infections (ARI) remain leading causes of under-five morbidity in low- and middle-income countries. Although Ghana achieved improved drinking water and sanitation coverage, significant regional and socioeconomic inequities persist. This study examined the associations between household water, sanitation, and hygiene (WASH) practices and diarrhea, ARI, and their comorbidity among under-five children in Ghana. METHODS: A cross-sectional analysis of 6344 children aged 0-59 months from the 2022 Ghana Demographic and Health Survey was conducted. Survey-weighted descriptive statistics and multilevel logistic regression were applied. Predictive performance was assessed using fivefold cluster-preserving cross-validation, Brier scores, calibration slopes, calibration plots, and cross-validated area under the curve (AUC). Spatial patterns were described using choropleth maps, Global Moran's I, Getis-Ord Gi*, and Local Moran's I (LISA). Counterfactual WASH reductions were estimated with bootstrap confidence intervals (200 replicates). A complementary random-effects meta-analysis quantified between-region heterogeneity (I(2)). RESULTS: Two-week prevalence of diarrhea, ARI, and comorbidity was 14.4% (95% CI: 12.7%-16.3%), 5.6% (95% CI: 4.7%-6.6%), and 1.8% (95% CI: 1.3%-2.5%), respectively, with a pronounced north-south gradient. No WASH variable reached significance in adjusted multilevel models. Diarrhea was associated with child age 6-35 months, maternal secondary and higher education, and household wealth. ARI was associated with co-occurring diarrhea and stunting. Stunting was the sole significant predictor of comorbidity. Community-level factors explained 21%-35% of variance. Cross-validated AUC was 0.787 (diarrhea), 0.896 (ARI), and 0.577 (comorbidity); calibration slopes were 3.68-11.68 (all poor). Global Moran's I showed no significant spatial autocorrelation for all three outcomes. Improving cooking fuel universally was the only scenario associated with a statistically significant absolute reduction in diarrhea prevalence: 1.4% points (relative reduction 13.9%; 95% CI: 6.2%-21.6%). CONCLUSIONS: Household WASH infrastructure showed no significant adjusted association with childhood diarrhea, ARI, or comorbidity after controlling for socioeconomic and nutritional confounders. A pronounced north-south disease gradient calls for geographically targeted, multisectoral interventions. Predictive models demonstrated adequate discrimination but poor calibration, limiting their use to population-level risk stratification. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Salifu, Yula AU - Salifu Y AUID- ORCID: 0000-0003-1223-1765 AD - Department of Population, Family and Reproductive Health, School of Public Health University of Ghana Legon Ghana. FAU - Gyan, Paul AU - Gyan P AD - Health Facilities Regulatory Agency Ashanti Region Ghana. FAU - Lasong, Joseph AU - Lasong J AD - Department of Population and Reproductive Health University for Development Studies Tamale Ghana. FAU - Walana, Williams AU - Walana W AUID- ORCID: 0000-0002-2938-1332 AD - Department of Clinical Microbiology, School of Medicine University for Development Studies Tamale Ghana. LA - eng PT - Journal Article DEP - 20260609 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13250393 OTO - NOTNLM OT - Ghana OT - WASH OT - acute respiratory infections OT - children under five OT - demographic and health survey OT - diarrhea OT - multilevel modeling OT - predictive modeling OT - spatial analysis COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/12 06:40 PMCR- 2026/06/09 CRDT- 2026/06/12 04:54 PHST- 2025/10/24 00:00 [received] PHST- 2026/04/04 00:00 [revised] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/06/12 06:40 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 04:54 [entrez] PHST- 2026/06/09 00:00 [pmc-release] AID - HSR272628 [pii] AID - 10.1002/hsr2.72628 [doi] PST - epublish SO - Health Sci Rep. 2026 Jun 9;9(6):e72628. doi: 10.1002/hsr2.72628. eCollection 2026 Jun. PMID- 42281323 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260612 IS - 1526-3711 (Electronic) IS - 1526-3711 (Linking) VI - 27 IP - 3 DP - 2026 Mar 1 TI - Evaluation of a Novel Zygomatic-based Cephalometric Angle for Sagittal Skeletal Discrepancy: A Retrospective Study. PG - 304-309 LID - 10.5005/jp-journals-10024-4036 [doi] AB - AIM: To evaluate the diagnostic accuracy of a novel zygomatic-based cephalometric parameter, the ZYen angle, for assessing sagittal skeletal discrepancies. MATERIALS AND METHODS: This retrospective cross-sectional study analyzed 369 pretreatment lateral cephalograms of subjects aged 18-25 years, equally distributed into skeletal class I (n = 123), class II (n = 123), and class III (n = 123) groups. Skeletal classification was performed using the A point-nasion-B point angle (ANB) and Wits appraisal. The ZYen angle, defined using points M, Z (zygomatic point), and D, was measured, and its diagnostic performance was assessed using one-way analysis of variance (ANOVA) and receiver operating characteristic (ROC) curve analysis to determine sensitivity, specificity, and area under the curve (AUC). RESULTS: The ZYen angle showed significant differences among skeletal classes (p < 0.001). Receiver operating characteristic analysis demonstrated excellent discrimination between skeletal class I and class III (AUC = 0.908), with a cut-off value of 29.5 degrees providing balanced sensitivity (78.9%) and specificity (82.9%). In contrast, discrimination between class I and class II was poor (AUC = 0.594), indicating limited diagnostic ability for identifying class II patterns. CONCLUSION: The ZYen angle is a reliable sagittal skeletal parameter with high diagnostic accuracy for distinguishing class I from class III relationships but limited utility in differentiating class II malocclusions. CLINICAL SIGNIFICANCE: Accurate sagittal skeletal diagnosis is essential for orthodontic treatment planning and prognosis. The ZYen angle utilizes stable zygomatic landmarks and minimizes reliance on cranial base and dental reference points, enhancing diagnostic confidence in class III cases. It may serve as a clinically useful adjunct to conventional cephalometric parameters, particularly in borderline or ambiguous sagittal discrepancies. CI - (c) The Author(s). 2026 Open Access. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/). This license permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited, a link to the license is included, and any changes are indicated. FAU - Shetty, Subramanya AU - Shetty S AUID- ORCID: 0009-0001-0803-7938 AD - Department of Orthodontics and Dentofacial Orthopaedics, Yenepoya Dental College, Yenepoya University, Mangaluru, Karnataka, India. FAU - Umar, Dilshad AU - Umar D AUID- ORCID: 0000-0002-1130-9359 AD - Department of Orthodontics and Dentofacial Orthopaedics, Yenepoya Dental College, Yenepoya University, Mangaluru, Karnataka, India, e-mail: orthodil@gmail.com. FAU - Egipsy, Kelly Ctm AU - Egipsy KC AUID- ORCID: 0009-0002-6999-8123 AD - Department of Orthodontics and Dentofacial Orthopaedics, Yenepoya Dental College, Yenepoya University, Mangaluru, Karnataka, India. FAU - Khais, Mohammed AU - Khais M AUID- ORCID: 0009-0001-4697-8499 AD - Department of Orthodontics and Dentofacial Orthopaedics, Yenepoya Dental College, Yenepoya University, Mangaluru, Karnataka, India. LA - eng PT - Journal Article DEP - 20260301 PL - India TA - J Contemp Dent Pract JT - The journal of contemporary dental practice JID - 101090552 SB - IM MH - Humans MH - *Cephalometry/methods MH - Retrospective Studies MH - *Zygoma/diagnostic imaging/anatomy & histology MH - Adolescent MH - Cross-Sectional Studies MH - Adult MH - Female MH - Young Adult MH - Male MH - Sensitivity and Specificity MH - ROC Curve MH - *Malocclusion/diagnosis/diagnostic imaging MH - Malocclusion, Angle Class II MH - Malocclusion, Angle Class III MH - Malocclusion, Angle Class I OTO - NOTNLM OT - Cephalometry OT - Malocclusion OT - Sagittal skeletal discrepancy OT - Zygoma COIS- None EDAT- 2026/06/12 06:39 MHDA- 2026/06/13 00:39 CRDT- 2026/06/12 02:44 PHST- 2026/02/03 00:00 [received] PHST- 2026/04/02 00:00 [accepted] PHST- 2026/06/13 00:39 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 02:44 [entrez] AID - 10.5005/jp-journals-10024-4036 [doi] PST - epublish SO - J Contemp Dent Pract. 2026 Mar 1;27(3):304-309. doi: 10.5005/jp-journals-10024-4036. PMID- 42281312 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260612 IS - 1526-3711 (Electronic) IS - 1526-3711 (Linking) VI - 27 IP - 3 DP - 2026 Mar 1 TI - Morphometric Evaluation of Cervical Vertebral Age and Mandibular Growth in Skeletal Class II Individuals Using Digital Cephalometry: A Cross-sectional Study. PG - 231-236 LID - 10.5005/jp-journals-10024-4008 [doi] AB - AIMS: This study examined the association between morphometric cervical vertebral bone (CVB) age and mandibular growth in Saudi individuals with skeletal class II malocclusion. MATERIALS AND METHODS: A retrospective cross-sectional analysis was performed using archived digital lateral cephalograms of 56 Saudi patients with skeletal class II malocclusion. Radiographs were categorized into a pubertal group (8-13 years; n = 28) and a postpubertal group (17-21 years; n = 28), with each group equally stratified by gender (14 males and 14 females). Mandibular length estimates calculated during the pubertal phase were compared with measured mandibular dimensions in postpubertal subjects, and sex-related growth differences were evaluated. Cervical vertebral bone age was calculated using vertebral morphometric measurements, and mandibular length (Condylion-Gnathion) was digitally assessed. Predicted mandibular lengths derived from CVB age were statistically compared with observed postpubertal values using independent t-tests, Cohen's d, and descriptive Bland-Altman analysis. RESULTS: Chronological age (CA) demonstrated no significant discrepancy from CVB age in either males (p = 0.28) or females (p = 0.63). Mandibular lengths predicted during the pubertal phase did not differ significantly from observed mandibular dimensions in the postpubertal group, for both sexes (p > 0.05). Bland-Altman analysis demonstrated minimal bias and acceptable group-level agreement, with higher precision in females. Males exhibited greater but more variable estimated growth potential than females. CONCLUSION: Morphometric CVB age showed good group-level agreement between mandibular length predicted during the pubertal phase (8-13 years) and measured postpubertal values (17-21 years) in Saudi skeletal class II subjects. CLINICAL SIGNIFICANCE: Accurate assessment of mandibular growth timing remains essential for optimizing orthopedic intervention in skeletal class II malocclusion. This study highlights the clinical applicability of CVB morphometric assessment as a practical, radiation-free approach using routine cephalograms to estimate mandibular growth potential and support informed treatment timing decisions. CI - (c) The Author(s). 2026 Open Access. This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (https://creativecommons.org/licenses/by-nc/4.0/). This license permits non-commercial use, distribution, and reproduction in any medium, provided the original author and source are credited, a link to the license is included, and any changes are indicated. FAU - Almugla, Yousef M AU - Almugla YM AD - Department of Preventive Dental Sciences, College of Dentistry, King Faisal University, Al Ahsa, Saudi Arabia, Phone: +966558555548, e-mail: yalmugla@kfu.edu.sa. LA - eng PT - Journal Article DEP - 20260301 PL - India TA - J Contemp Dent Pract JT - The journal of contemporary dental practice JID - 101090552 SB - IM MH - Humans MH - *Cervical Vertebrae/growth & development/diagnostic imaging/anatomy & histology MH - Adolescent MH - Cross-Sectional Studies MH - *Cephalometry/methods MH - *Malocclusion, Angle Class II/diagnostic imaging/physiopathology MH - Female MH - *Mandible/growth & development/diagnostic imaging MH - Child MH - Male MH - Retrospective Studies MH - *Age Determination by Skeleton/methods MH - Young Adult MH - Saudi Arabia OTO - NOTNLM OT - Cephalometric analysis OT - Cervical vertebral age OT - Class II malocclusion OT - Jaw bone OT - Mandibular growth OT - Orthodontics OT - Prediction COIS- None EDAT- 2026/06/12 06:37 MHDA- 2026/06/12 06:38 CRDT- 2026/06/12 02:44 PHST- 2025/12/25 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/06/12 06:38 [medline] PHST- 2026/06/12 06:37 [pubmed] PHST- 2026/06/12 02:44 [entrez] AID - 10.5005/jp-journals-10024-4008 [doi] PST - epublish SO - J Contemp Dent Pract. 2026 Mar 1;27(3):231-236. doi: 10.5005/jp-journals-10024-4008. PMID- 42280894 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 11 DP - 2026 May 26 TI - Estimation of Vertical Ground Reaction Forces During Vertical Jumping in Children Using OpenCap. LID - 10.3390/s26113375 [doi] LID - 3375 AB - Vertical ground reaction force is an important parameter for describing the developmental characteristics of young children's vertical jumping. However, its application in large-scale physical fitness monitoring and routine teaching practice is greatly limited. Previous studies have used OpenCap to estimate vertical ground reaction force during adult jumping tasks and have provided preliminary validation, but its effectiveness in young children remains unclear. To examine the correlation and agreement of vertical ground reaction force (GRF) estimated by the OpenCap markerless motion capture system during young children's vertical jumping and to explore the characteristics of vertical GRF estimated by OpenCap during the vertical jump. Kinematic and kinetic data during vertical jumping were synchronously collected from 16 young children using the OpenCap markerless motion capture system and a three-dimensional force platform, with each child completing three trials. Kinematic data were acquired using the OpenCap markerless motion capture system, and the vertical acceleration of the whole-body center of mass was calculated to estimate vertical GRF based on Newton's second law. Pearson linear correlation analysis and Bland-Altman analysis were used to examine the differences in characteristics between the estimated vertical GRF and the measured vertical GRF. The vertical GRF characteristics estimated by OpenCap showed moderate-to-high correlations with the measured values. Specifically, the time and mean impulse during the push-off phase, flight phase, and landing stabilization phase were highly correlated (r > 0.85), while the peak force and mean force during the push-off phase showed moderate-to-high correlations (r > 0.7). Bland-Altman analysis showed that the bias in time and impulse during the vertical jump was less than 15%, indicating relatively high agreement; however, the bias in peak force during the landing phase exceeded 40%, indicating weak agreement. These results suggest that the OpenCap markerless motion capture system can effectively estimate vertical GRF characteristics during young children's vertical jumping, with the best performance observed for vertical GRF variables in the push-off phase. The method used in this study may be applied to obtain vertical GRF during young children's vertical jumping in non-laboratory settings and to assist in evaluating the developmental level of young children's vertical jump performance. Nevertheless, OpenCap-derived rapid impact variables, particularly landing peak force, should be interpreted with caution. FAU - You, Jiongyi AU - You J AD - School of Sports, Southwest University, Chongqing 400715, China. FAU - Lin, Zhicheng AU - Lin Z AD - School of Sports, Southwest University, Chongqing 400715, China. FAU - Zhang, Baifa AU - Zhang B AUID- ORCID: 0000-0002-6746-0066 AD - School of Sports, Southwest University, Chongqing 400715, China. LA - eng GR - 23CTY017/Chinese Academy of Social Sciences/ PT - Journal Article DEP - 20260526 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - Biomechanical Phenomena/physiology MH - Motion Capture MH - Child MH - Male MH - Female MH - Movement/physiology PMC - PMC13259095 OTO - NOTNLM OT - OpenCap OT - children OT - markerless motion capture OT - vertical ground reaction force OT - vertical jump COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/06/12 06:39 MHDA- 2026/06/12 18:40 PMCR- 2026/05/26 CRDT- 2026/06/12 01:13 PHST- 2026/04/11 00:00 [received] PHST- 2026/05/21 00:00 [revised] PHST- 2026/05/22 00:00 [accepted] PHST- 2026/06/12 18:40 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 01:13 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - s26113375 [pii] AID - sensors-26-03375 [pii] AID - 10.3390/s26113375 [doi] PST - epublish SO - Sensors (Basel). 2026 May 26;26(11):3375. doi: 10.3390/s26113375. PMID- 42280454 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 Jun 4 TI - Exploring Subpopulations for Epidemiological Precision Nutrition Research: The Example of Phenylalanine Hydroxylase (PAH) Genetic Variation. LID - 10.3390/nu18111811 [doi] LID - 1811 AB - Background/Objectives: Biological factors such as genetics contribute to nutrition-related outcomes, but nutritional epidemiological studies often lack consideration of genetics despite evidence of their functional impacts on health and cognition. Phenylalanine hydroxylase (PAH) genetic variation has been hypothesized to influence health and cognitive outcomes due to evidence of metabolic perturbations in L-phenylalanine to L-tyrosine hydroxylation, including plausible downstream effects on catecholamine neurotransmitters among not only individuals with phenylketonuria (PKU) [homozygotes for PAH mutations] but also PKU carriers [heterozygotes]. Related to these metabolic perturbations, diminished executive functioning has been observed in individuals with PKU, even when treated, but research is lacking exploring this outcome in PKU carriers. The present study aims to detail methods for stratifying populations based on genetic variation, for use in epidemiological precision nutrition research. It further provides an exploratory exemplar of such research through population stratification by PAH genetic variation (i.e., PKU carriers vs. non-carriers), while providing the first descriptive data on executive functioning skills using the validated Executive Skills Questionnaire-Revised (ESQ-R) tool with PAH-genetically stratified groups (PKU carriers and non-carriers). Methods: Participants were >/=18 years of age and PAH heterozygotes (PKU carriers) or non-carriers. Levels of executive functioning were self-reported anonymously online and included the validated Executive Skills Questionnaire-Revised (ESQ-R) tool. Data were analyzed using t-tests, chi-square tests, ANOVAs, and ANCOVAs. Results: Respondents (n = 99, n = 79 carriers and n = 20 non-carriers) consisted of males (22.2%) and females (77.8%), primarily of European ancestry. There were no significant differences between groups (carriers vs. non-carriers) for total scores (mean +/- SD ESQ-R score carriers = 17.41 +/- 14.01; non-carriers = 14.95 +/- 10.00), but carriers scored significantly worse than non-carriers for the ESQ-R item "I have trouble making a plan" in the adjusted model. Conclusions: This study provides a methodological exemplar for exploring genetically stratified subpopulations in epidemiological precision nutrition research. FAU - Dhawan, Anoushka AU - Dhawan A AD - Department of Human Health Sciences, College of Biological Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. FAU - Khan, Sophia M AU - Khan SM AD - Department of Human Health Sciences, College of Biological Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. FAU - Fennell, Madison L AU - Fennell ML AD - Department of Human Health Sciences, College of Biological Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. FAU - Cho, Clara E AU - Cho CE AUID- ORCID: 0000-0002-9733-2516 AD - Department of Human Health Sciences, College of Biological Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. FAU - Monk, Jennifer M AU - Monk JM AD - Department of Human Health Sciences, College of Biological Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. FAU - Keathley, Justine R AU - Keathley JR AUID- ORCID: 0000-0002-9176-9645 AD - Department of Human Health Sciences, College of Biological Sciences, University of Guelph, Guelph, ON N1G 2W1, Canada. LA - eng PT - Journal Article DEP - 20260604 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - EC 1.14.16.1 (Phenylalanine Hydroxylase) SB - IM MH - Humans MH - *Phenylalanine Hydroxylase/genetics MH - *Phenylketonurias/genetics MH - Female MH - *Genetic Variation MH - Male MH - Adult MH - Heterozygote MH - Executive Function MH - Young Adult MH - Adolescent MH - Middle Aged PMC - PMC13259265 OTO - NOTNLM OT - PKU OT - PKU parents OT - executive functioning OT - heterozygotes OT - phenylketonuria COIS- The authors declare no conflict of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/15 11:34 PMCR- 2026/06/04 CRDT- 2026/06/12 01:11 PHST- 2026/04/28 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/06/15 11:34 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/06/04 00:00 [pmc-release] AID - nu18111811 [pii] AID - nutrients-18-01811 [pii] AID - 10.3390/nu18111811 [doi] PST - epublish SO - Nutrients. 2026 Jun 4;18(11):1811. doi: 10.3390/nu18111811. PMID- 42280414 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 30 TI - Cultural and Sex-Related Differences in Free-Word Associations with "Sweets": A Multinational Online Study. LID - 10.3390/nu18111771 [doi] LID - 1771 AB - Background: Free-word association (FWA) captures the most accessible lexical responses to a stimulus, providing a window into automatic cognitive representations of food categories that may differ across cultures and between sexes. Objectives: To examine whether the dominant cognitive associations evoked by the word "sweets" differ across three language groups (Hungarian, English, Spanish), whether they vary by sex, and whether they relate to body mass index (BMI) and self-reported eating disorder risk. Methods: A total of 1349 participants completed an online survey including a single FWA prompt. Responses were classified into 10 semantic categories and analyzed using chi-square tests. Effect sizes (Cramer's V) were reported for all tests. Height and weight were converted to uniform metric units, and BMI was calculated. Results: The association profile differed significantly across language groups (chi(2)[18] = 210.05, p < 0.001, V = 0.28). Chocolate dominated Hungarian responses, while Baked goods/Desserts and Sugar/Candy dominated English, and Positive emotion and Baked goods/Desserts predominated among Spanish speakers. Sex differences were significant overall (chi(2)[9] = 43.72, p < 0.001, V = 0.18). BMI distributions differed markedly across nations (chi(2)[6] = 157.17, p < 0.001, V = 0.26), and sweets categories were significantly associated with eating disorder risk (chi(2)[27] = 48.04, p = 0.008, V = 0.11); however, this result should be interpreted with caution given the extreme skew toward the lowest-risk category [84.2%], with Negative/Health associations overrepresented among higher-risk participants. Conclusions: Cultural context plays a significant role in shaping automatic cognitive associations with sweet foods. The exploratory association between sweets categories and self-reported eating disorder risk warrants further investigation using validated instruments before any substantive conclusions can be drawn. FAU - Avena, Nicole AU - Avena N AD - Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. AD - Health Psychology, Princeton University, Princeton, NJ 08544, USA. FAU - Kovacs, Reka Erika AU - Kovacs RE AUID- ORCID: 0009-0007-0243-6878 AD - Faculty of Health and Sport Sciences, Szechenyi Istvan University, 9026 Gyor, Hungary. FAU - Somogyi, Angela AU - Somogyi A AD - Faculty of Health and Sport Sciences, Szechenyi Istvan University, 9026 Gyor, Hungary. FAU - de la Vega, Ricardo AU - de la Vega R AUID- ORCID: 0000-0002-7395-3297 AD - Departamento de Educacion Fisica, Deporte y Motricidad Humana, Universidad Autonoma de Madrid, 28049 Madrid, Spain. FAU - Szabo, Attila AU - Szabo A AUID- ORCID: 0000-0003-2788-4304 AD - Faculty of Health and Sport Sciences, Szechenyi Istvan University, 9026 Gyor, Hungary. LA - eng PT - Journal Article DEP - 20260530 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Female MH - Body Mass Index MH - Sex Factors MH - Adult MH - Feeding and Eating Disorders/psychology MH - Young Adult MH - Language MH - *Food Preferences/psychology/ethnology MH - *Cross-Cultural Comparison MH - Adolescent MH - Surveys and Questionnaires MH - Cognition PMC - PMC13258868 OTO - NOTNLM OT - BMI OT - cross-cultural OT - eating behavior OT - eating disorders OT - free-word association OT - sex differences COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:38 MHDA- 2026/06/13 00:38 PMCR- 2026/05/30 CRDT- 2026/06/12 01:11 PHST- 2026/04/03 00:00 [received] PHST- 2026/05/27 00:00 [revised] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/06/13 00:38 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - nu18111771 [pii] AID - nutrients-18-01771 [pii] AID - 10.3390/nu18111771 [doi] PST - epublish SO - Nutrients. 2026 May 30;18(11):1771. doi: 10.3390/nu18111771. PMID- 42280409 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 30 TI - Oral Mycobiome Alterations in Children with Phenylketonuria: Associations with Dietary Intake and Metabolic Context-A Pilot Study. LID - 10.3390/nu18111764 [doi] LID - 1764 AB - BACKGROUND: Phenylketonuria (PKU) is a metabolic disorder requiring a strict low-phenylalanine diet. Oral health impairment, including bacteriome dysbiosis, is common in PKU, yet the mycobiome remains poorly defined. This pilot study aimed to characterise the salivary oral mycobiome of children with PKU compared with controls and to explore associations with dietary intake. METHODS: Saliva samples from 18 children, including 8 patients with PKU and 10 age-matched controls, were profiled using internal transcribed spacer (ITS) amplicon sequencing. Alpha/beta diversity, taxonomic composition, diet-fungi correlations, discriminative taxa and LEfSe were analysed. RESULTS: Alpha diversity did not differ significantly between groups after correction for multiple comparisons, although exploratory subgroup analyses suggested lower evenness in PKU children aged <10 years compared with older controls. Beta diversity differed by diagnosis (PERMANOVA: F = 1.7251, p = 0.0062) and in the age-diagnosis model (F = 1.8502, p = 0.0004). Taxonomic analyses identified nominal differences in several fungal taxa, including Candida (p = 0.011), Saccharomycetales_fam_Incertae_sedis (p = 0.011), Naganishia (p = 0.020), and Aspergillaceae (p = 0.036) in PKU samples; however, these findings should be interpreted as exploratory because many did not remain significant after FDR correction. Diet-mycobiome analyses identified selected FDR-supported associations, including an inverse relationship between phenylalanine intake and Naganishia in PKU. CONCLUSIONS: This pilot study suggests preliminary compositional differences in the oral mycobiome of children with PKU that may be related to dietary therapy and metabolic context. These exploratory findings require validation in larger cohorts with detailed oral health assessment and control of confounders. FAU - Ostrowska, Malgorzata AU - Ostrowska M AUID- ORCID: 0000-0002-1218-3225 AD - Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, 20-704 Lublin, Poland. FAU - Komon-Janczara, Elwira AU - Komon-Janczara E AUID- ORCID: 0000-0003-4579-4994 AD - Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, 20-704 Lublin, Poland. FAU - Mikoluc, Bozena AU - Mikoluc B AUID- ORCID: 0000-0002-8284-6426 AD - Department of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Medical University of Bialystok, 15-274 Bialystok, Poland. FAU - Ilowiecka, Katarzyna AU - Ilowiecka K AD - Nutrition Clinic, Department of Clinical Dietetics, Medical University of Lublin, 20-093 Lublin, Poland. FAU - Jarczak, Justyna AU - Jarczak J AUID- ORCID: 0000-0002-4357-7681 AD - Laboratory of Regenerative Medicine, Preclinical Research and Technology Center, Medical University of Warsaw, 02-097 Warsaw, Poland. FAU - Zagorska, Justyna AU - Zagorska J AUID- ORCID: 0000-0002-7869-2882 AD - Department of Food and Nutrition, Medical University of Lublin, 20-093 Lublin, Poland. FAU - Zambrzycka, Paulina AU - Zambrzycka P AD - Metabolic Clinic, Department of Pediatrics, Rheumatology, Immunology and Metabolic Bone Diseases, Ludwig Zamenhoff University Children's Clinical Hospital, Medical University of Bialystok, 15-274 Bialystok, Poland. FAU - Turroni, Silvia AU - Turroni S AUID- ORCID: 0000-0003-2345-9482 AD - Unit of Microbiome Science and Biotechnology, Department of Pharmacy and Biotechnology, University of Bologna, 40126 Bologna, Italy. FAU - Szczerba, Hubert AU - Szczerba H AD - Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, 20-704 Lublin, Poland. LA - eng GR - 2022/06/X/NZ9/00519/National Science Centre/ PT - Journal Article DEP - 20260530 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Phenylketonurias/microbiology/metabolism MH - Pilot Projects MH - Male MH - Female MH - Child MH - *Diet MH - *Saliva/microbiology MH - *Mycobiome MH - Child, Preschool MH - Case-Control Studies MH - *Mouth/microbiology MH - *Fungi/classification PMC - PMC13259183 OTO - NOTNLM OT - fungal community shifts OT - metabolic disorders OT - nutrient-microbiome interactions OT - oral mycobiome OT - pediatric nutrition OT - phenylketonuria (PKU) COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/15 11:36 PMCR- 2026/05/30 CRDT- 2026/06/12 01:11 PHST- 2026/04/30 00:00 [received] PHST- 2026/05/24 00:00 [revised] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/06/15 11:36 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - nu18111764 [pii] AID - nutrients-18-01764 [pii] AID - 10.3390/nu18111764 [doi] PST - epublish SO - Nutrients. 2026 May 30;18(11):1764. doi: 10.3390/nu18111764. PMID- 42280399 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 29 TI - Ponderal Status, Eating and Lifestyle Habits in Rural School Children: A Pilot Survey of the SBAM-ONFOODS Cohort Study. LID - 10.3390/nu18111756 [doi] LID - 1756 AB - Background/Objectives: The rising prevalence of overweight and obesity reflects a trend towards worsening eating habits and reduced physical activity, with significant implications for public health and life expectancy. This pilot survey aimed to evaluate weight status, food habits and lifestyle in primary school children from under-researched rural areas of the Lazio region, Italy. Methods: A total of 182 children aged 6-10 years from the municipalities of Monte Romano and Tolfa were enrolled. Body Mass Index (BMI), calculated from measured weight and height, was classified by IOTF and WHO definitions. Food habits, socioeconomic factors and lifestyle were evaluated by a standard questionnaire, and adherence to the Mediterranean diet (MD) was assessed by the KIDMED test. Results: Data showed a high prevalence of overweight, including obesity (33.3%), based on IOTF criteria, with slightly higher rates in boys than girls (38.3% vs. 26.9%). According to the WHO definition, the rate of overweight/obesity was 39.5% with significant differences between males and females (46% vs. 30.8%). Only 19.9% of children had high adherence to MD (67.3% moderate, 12.9% low), and 29.5% of the sample did not eat breakfast every day. In addition, 25.4% met international physical activity recommendations, while around 40% exceeded the recommended screen time on weekend days, and 19.3% did not sleep the recommended hours. Conclusions: Preliminary data show high rates of excess weight, poor diet quality and unhealthy lifestyles. Extending the sampling to other municipalities in the study area will help validate these findings and provide deeper insights to inform targeted intervention strategies. FAU - Galfo, Myriam AU - Galfo M AUID- ORCID: 0000-0003-4037-2979 AD - Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agraria (CREA), Centro di Ricerca Alimenti e Nutrizione (Council for Agricultural Research and Economics, Research Centre for Food and Nutrition), Via Ardeatina 546, 00178 Rome, Italy. FAU - D'Addezio, Laura AU - D'Addezio L AUID- ORCID: 0000-0003-3392-5539 AD - Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agraria (CREA), Centro di Ricerca Alimenti e Nutrizione (Council for Agricultural Research and Economics, Research Centre for Food and Nutrition), Via Ardeatina 546, 00178 Rome, Italy. FAU - Roccaldo, Romana AU - Roccaldo R AUID- ORCID: 0000-0003-2976-3864 AD - Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agraria (CREA), Centro di Ricerca Alimenti e Nutrizione (Council for Agricultural Research and Economics, Research Centre for Food and Nutrition), Via Ardeatina 546, 00178 Rome, Italy. FAU - Censi, Laura AU - Censi L AUID- ORCID: 0000-0002-8769-6914 AD - Consiglio per la Ricerca in Agricoltura e l'Analisi dell'Economia Agraria (CREA), Centro di Ricerca Alimenti e Nutrizione (Council for Agricultural Research and Economics, Research Centre for Food and Nutrition), Via Ardeatina 546, 00178 Rome, Italy. LA - eng GR - PE00000003/European Union/ PT - Journal Article DEP - 20260529 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Pilot Projects MH - *Feeding Behavior MH - *Life Style MH - *Rural Population/statistics & numerical data MH - Italy/epidemiology MH - Body Mass Index MH - Prevalence MH - Diet, Mediterranean MH - Overweight/epidemiology MH - *Pediatric Obesity/epidemiology MH - Cohort Studies MH - Exercise MH - Socioeconomic Factors MH - Surveys and Questionnaires PMC - PMC13258498 OTO - NOTNLM OT - children OT - food habits OT - lifestyle OT - ponderal status COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/15 11:31 PMCR- 2026/05/29 CRDT- 2026/06/12 01:11 PHST- 2026/04/21 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/06/15 11:31 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - nu18111756 [pii] AID - nutrients-18-01756 [pii] AID - 10.3390/nu18111756 [doi] PST - epublish SO - Nutrients. 2026 May 29;18(11):1756. doi: 10.3390/nu18111756. PMID- 42280396 OWN - NLM STAT- MEDLINE DCOM- 20260614 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 29 TI - Effect of a Theory-Informed, Six-Week Gamified Educational Intervention on Hydration Knowledge, Behavior, and Status in School Children: A Randomized Controlled Trial. LID - 10.3390/nu18111753 [doi] LID - 1753 AB - Aim: This study assessed the effects of a six-week educational intervention using an adapted "Snakes and Ladders" board game on hydration knowledge, behavior, and status among Tunisian elementary school children during physical education (PE) lessons. Method: A randomized controlled trial involving 207 children was conducted, with participants assigned to either the educational group (EG, n = 99) or the control group (CG, n = 108). The EG participated in six weekly 30-min board game sessions, while the CG continued regular activities. Knowledge of hydration was assessed using a validated questionnaire. Hydration status was monitored indirectly by the percentage change in body mass from pre- to post-PE session. Perceived thirst was evaluated using a 9-point scale, and hydration behavior was evaluated based on water consumption during PE lessons. Results: Following the intervention, the EG demonstrated a significant improvement in overall hydration knowledge (DeltaMean = +0.30 +/- 0.11 vs. -0.05 +/- 0.08 in CG; p < 0.001). Water intake during PE sessions increased progressively from week 2 (83.6 +/- 127.2 mL) to week 6 (311.2 +/- 204 mL) in the EG, whereas it remained unchanged in the CG (p < 0.001). Body mass loss after PE sessions decreased significantly in the EG (-0.03 kg) compared with the CG (-0.16 kg; p < 0.001), and perceived thirst before and after PE sessions was markedly lower (Cohen's d = 0.75-1.32). Conclusions. The six-week board-game intervention appeared effective in increasing hydration knowledge, promoting healthier drinking behaviors during PE, and improving indirect indicators of hydration status. These findings provide preliminary evidence for the feasibility and educational value of a gamified, low-cost approach to hydration promotion in schools. Further research should examine long-term retention, include objective hydration biomarkers, and evaluate applicability across diverse school settings and environmental conditions. FAU - Kacem, Sana AU - Kacem S AUID- ORCID: 0009-0008-9542-3511 AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. AD - Research Laboratory, Education, Motricity, Sport and Health (EM2S), LR15JS01, High Institute of Sport and Physical Education, University of Sfax, Sfax 3000, Tunisia. FAU - Trabelsi, Khaled AU - Trabelsi K AUID- ORCID: 0000-0003-2623-9557 AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. AD - Research Laboratory, Education, Motricity, Sport and Health (EM2S), LR15JS01, High Institute of Sport and Physical Education, University of Sfax, Sfax 3000, Tunisia. AD - Department of Movement Sciences and Sports Training, School of Sport Science, The University of Jordan, Amman 11942, Jordan. FAU - Ceylan, Halil Ibrahim AU - Ceylan HI AUID- ORCID: 0009-0005-2214-4667 AD - Department of Physical Education of Sports Teaching, Faculty of Sports Sciences, Ataturk University, 25240 Erzurum, Turkiye. FAU - Khacharem, Aimen AU - Khacharem A AUID- ORCID: 0000-0001-9088-3967 AD - College of Sport Sciences, Qatar University, Doha 2713, Qatar. FAU - Ammar, Achraf AU - Ammar A AUID- ORCID: 0000-0003-0347-8053 AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax 3000, Tunisia. AD - Department of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, 55122 Mainz, Germany. AD - Research Laboratory, Molecular Bases of Human Pathology, LR19ES13, Faculty of Medicine, University of Sfax, Sfax 3000, Tunisia. AD - Department of Nutrition and Food Technology, School of Agriculture, The University of Jordan, Amman 11942, Jordan. FAU - Clark, Cain C T AU - Clark CCT AUID- ORCID: 0000-0002-6610-4617 AD - School of Life and Health Sciences, Birmingham City University, Birmingham B15 3TN, UK. FAU - Abed, Kais El AU - Abed KE AUID- ORCID: 0000-0001-9085-6379 AD - Research Laboratory, Education, Motricity, Sport and Health (EM2S), LR15JS01, High Institute of Sport and Physical Education, University of Sfax, Sfax 3000, Tunisia. FAU - Jahrami, Haitham AU - Jahrami H AUID- ORCID: 0000-0001-8990-1320 AD - Department of Psychiatry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama 329, Bahrain. FAU - Muntean, Raul Ioan AU - Muntean RI AUID- ORCID: 0000-0003-4615-6687 AD - Department of Physical Education and Sport, Faculty of Law and Social Sciences, University "1 Decembrie 1918" of Alba Iulia, 510009 Alba Iulia, Romania. FAU - Dergaa, Ismail AU - Dergaa I AUID- ORCID: 0000-0001-8091-1856 AD - High Institute of Sport and Physical Education of Kef, University of Jendouba, Jendouba 7100, Tunisia. AD - Physical Activity Research Unit, Sport and Health (UR18JS01), National Observatory of Sports, Tunis 1003, Tunisia. FAU - Bragazzi, Nicola Luigi AU - Bragazzi NL AD - Department of Clinical Pharmacy, Saarland University, 66123 Saarbrucken, Germany. FAU - Aziz, Abdul Rashid AU - Aziz AR AUID- ORCID: 0000-0002-7727-7484 AD - Sport Science and Sports Medicine, Singapore Sport Institute, Singapore 397630, Singapore. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260529 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Female MH - *Health Knowledge, Attitudes, Practice MH - Male MH - *Drinking MH - *Physical Education and Training/methods MH - *Dehydration/prevention & control MH - Thirst MH - Surveys and Questionnaires MH - Schools MH - Child Behavior PMC - PMC13259264 OTO - NOTNLM OT - behavior OT - board game OT - body hydration status OT - children OT - game-based intervention OT - health promotion COIS- All authors declare no conflicts of interest. EDAT- 2026/06/12 06:38 MHDA- 2026/06/15 11:33 PMCR- 2026/05/29 CRDT- 2026/06/12 01:11 PHST- 2026/04/16 00:00 [received] PHST- 2026/05/14 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/06/15 11:33 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - nu18111753 [pii] AID - nutrients-18-01753 [pii] AID - 10.3390/nu18111753 [doi] PST - epublish SO - Nutrients. 2026 May 29;18(11):1753. doi: 10.3390/nu18111753. PMID- 42280338 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 26 TI - Development of a Metagenomics-Guided Personalized Synbiotic Protocol for Children with Autism Spectrum Disorder: An Exploratory Case Series. LID - 10.3390/nu18111694 [doi] LID - 1694 AB - BACKGROUND/OBJECTIVES: Gut microbiota dysregulation has been increasingly implicated in the pathophysiology of autism spectrum disorder (ASD), yet clinical responses to standardized probiotic interventions remain inconsistent, likely reflecting substantial inter-individual variability in baseline microbiome composition, host-microbe interactions, immune tone, and metabolic function. Here, we present a pilot implementation of a metagenomics-guided, personalized synbiotic intervention in children with ASD using the Systematic Microbiome Assessment and Reconstruction Therapy (SMART) framework. METHODS: Seven children (aged 5-12 years) underwent longitudinal fecal shotgun metagenomic profiling, and dietary habits, food sensitivities, and regional dietary background were recorded as contextual factors potentially influencing microbiome composition and response to intervention. Individualized synbiotic formulations were constructed based on microbial taxonomic composition and inferred functional capacity and iteratively refined over time. Gastrointestinal outcomes were assessed through caregiver-reported clinical observations, whereas behavioral changes were evaluated using standardized instruments. RESULTS: Several participants demonstrated improvements in gastrointestinal symptoms and selected behavioral domains. Notably, in a subset of participants, improvements in gastrointestinal function preceded measurable behavioral changes. CONCLUSIONS: Although limited by a small sample size and lack of a control group, these findings provide preliminary evidence supporting the feasibility of implementing a metagenomics-guided personalized synbiotic framework in ASD and generate hypotheses for future investigation. This work presents a preliminary conceptual framework for integrating microbial composition and inferred functional profiling into individualized intervention design and highlights the potential value of microbiome-informed stratification in future studies of treatment response. Larger controlled studies with objective outcome measures are warranted to further evaluate feasibility, reproducibility, and potential clinical utility. FAU - Zhang, Shaohan AU - Zhang S AUID- ORCID: 0009-0009-4106-4928 AD - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA. FAU - Liu, Kevin AU - Liu K AUID- ORCID: 0000-0002-8754-3504 AD - Fetal-Neonatal Neuroimaging and Developmental Science Center, Department of Newborn Medicine, Boston Children's Hospital, 300 Longwood Ave., Boston, MA 02115, USA. FAU - Shi, Leo AU - Shi L AUID- ORCID: 0009-0001-6741-7746 AD - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA. FAU - Yan, Chuyao AU - Yan C AUID- ORCID: 0009-0008-8933-5224 AD - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA. FAU - Wang, Alma AU - Wang A AUID- ORCID: 0009-0000-1366-9051 AD - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA. FAU - Liu, Ashley AU - Liu A AUID- ORCID: 0009-0002-4208-425X AD - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA. FAU - Guo, Haiyi AU - Guo H AUID- ORCID: 0009-0000-3777-4892 AD - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA. AD - Fetal-Neonatal Neuroimaging and Developmental Science Center, Department of Newborn Medicine, Boston Children's Hospital, 300 Longwood Ave., Boston, MA 02115, USA. FAU - Xie, Alex AU - Xie A AUID- ORCID: 0009-0005-5431-8764 AD - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA. FAU - Kong, Xue-Jun AU - Kong XJ AUID- ORCID: 0000-0001-8551-8877 AD - Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA 02129, USA. AD - Fetal-Neonatal Neuroimaging and Developmental Science Center, Department of Newborn Medicine, Boston Children's Hospital, 300 Longwood Ave., Boston, MA 02115, USA. AD - Department of Medicine and Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA. LA - eng GR - 92436/Boston Children's Hospital/ GR - 233263/Massachusetts General Hospital/ PT - Journal Article DEP - 20260526 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Synbiotics/administration & dosage MH - *Metagenomics/methods MH - Child, Preschool MH - *Autism Spectrum Disorder/microbiology/therapy MH - Male MH - Child MH - Female MH - Pilot Projects MH - Feces/microbiology MH - *Gastrointestinal Microbiome MH - Treatment Outcome MH - *Precision Medicine/methods PMC - PMC13257912 OTO - NOTNLM OT - autism spectrum disorder OT - gut-brain axis OT - metagenomics OT - microbiota OT - personalized microbiome intervention OT - precision psychiatry OT - synbiotics COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/13 00:38 PMCR- 2026/05/26 CRDT- 2026/06/12 01:11 PHST- 2026/04/16 00:00 [received] PHST- 2026/05/21 00:00 [revised] PHST- 2026/05/23 00:00 [accepted] PHST- 2026/06/13 00:38 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - nu18111694 [pii] AID - nutrients-18-01694 [pii] AID - 10.3390/nu18111694 [doi] PST - epublish SO - Nutrients. 2026 May 26;18(11):1694. doi: 10.3390/nu18111694. PMID- 42280337 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 26 TI - Maternal Methyl-Group Donor Intake and Neonatal Birth Size in Singleton IVF Pregnancies. LID - 10.3390/nu18111693 [doi] LID - 1693 AB - Background/Objectives: Maternal intake of methyl-group donors (MGD) during pregnancy may influence fetal development, yet its role in in vitro fertilization (IVF) pregnancies remains poorly understood. The aim of the present study was to investigate maternal intake of MGDs during late pregnancy and its association with neonatal outcomes in IVF versus spontaneously (S) conceived pregnancies. Methods: We assessed third-trimester, daily maternal intake of MGD (folate, betaine, choline, methionine, and folic acid) using a validated food-frequency questionnaire, and maternal supplement intake using a structured questionnaire. Methyl-donor nutrient score (MDNS) was calculated based on deciles of MGD intake. Serum folic acid and vitamin B12 concentrations were measured using standardized immunochemical assay. Predefined inclusion and exclusion criteria were applied. Anthropometric data were measured from singleton newborns (weight, length, head- and waist circumference, body composition) and mothers (height, weight, body composition) after delivery. Statistical analysis was conducted using R (4.1.2v). Results: 265 mother-child pairs were included in the study (IVF n = 83). Daily dietary intake of MGDs was similar between groups, but IVF mothers reported significantly higher daily folic acid (668.7 +/- 1050.9 vs. 418.8 +/- 419.2 microg, p = 0.0034) and vitamin B12 (11.07 +/- 31.58 vs. 7.95 +/- 29.00 microg, p = 0.0078) supplementation. Serum analyses were available in a subgroup (n = 131, IVF n = 61) of mothers, showing higher postpartum folate (IVF: 10.96 +/- 5.54 vs. S: 8.29 +/- 4.72 microg/L, p = 0.0064) and vitamin B12 (IVF: 288.22 +/- 113.82 vs. S: 233.70 +/- 78.23 ng/L, p = 0.0053). Maternal daily dietary choline intakes were significantly below recommendations (IVF: 251.9 +/- 98.5 mg, S: 243.8 +/- 106.8 mg). Among 151 singleton neonates (IVF n = 57), anthropometric parameters did not differ between IVF and spontaneously conceived groups and were not associated with MDNS tertiles. Conclusions: Maternal MGD intake during third trimester of pregnancy was not associated with neonatal anthropometric outcomes in singleton pregnancies. Consistently low dietary choline intake highlights a potential nutritional gap warranting improved dietary guidance and supplementation strategies. FAU - Bokor, Szilvia AU - Bokor S AD - Department of Pediatrics, Medical School, University of Pecs, 7623 Pecs, Hungary. AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Molecular Medicine Research Group, Szentagothai Research Centre, University of Pecs, 7623 Pecs, Hungary. FAU - Felso, Regina AU - Felso R AUID- ORCID: 0000-0001-5646-2093 AD - Department of Pediatrics, Medical School, University of Pecs, 7623 Pecs, Hungary. AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Hungarian Centre of Genomics and Bioinformatics, Szentagothai Research Centre, University of Pecs, 7623 Pecs, Hungary. FAU - Csolle, Ildiko AU - Csolle I AUID- ORCID: 0000-0003-3582-2541 AD - Department of Pediatrics, Medical School, University of Pecs, 7623 Pecs, Hungary. AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Cochrane Hungary, Medical School, University of Pecs, 7623 Pecs, Hungary. FAU - Olah, Ticia AU - Olah T AD - Department of Pediatrics, Medical School, University of Pecs, 7623 Pecs, Hungary. FAU - Szabo, Noemi AU - Szabo N AD - Department of Pediatrics, Medical School, University of Pecs, 7623 Pecs, Hungary. FAU - Herczeg, Robert AU - Herczeg R AD - Hungarian Centre of Genomics and Bioinformatics, Szentagothai Research Centre, University of Pecs, 7623 Pecs, Hungary. FAU - Gyenesei, Attila AU - Gyenesei A AD - Hungarian Centre of Genomics and Bioinformatics, Szentagothai Research Centre, University of Pecs, 7623 Pecs, Hungary. FAU - Vass, Reka Anna AU - Vass RA AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Department of Obstetrics and Gynecology, Medical School, University of Pecs, 7623 Pecs, Hungary. FAU - Funke, Simone AU - Funke S AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Department of Obstetrics and Gynecology, Medical School, University of Pecs, 7623 Pecs, Hungary. FAU - Ertl, Tibor AU - Ertl T AUID- ORCID: 0000-0003-3650-7084 AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Department of Obstetrics and Gynecology, Medical School, University of Pecs, 7623 Pecs, Hungary. FAU - Molnar, Denes AU - Molnar D AUID- ORCID: 0000-0002-3675-7019 AD - Department of Pediatrics, Medical School, University of Pecs, 7623 Pecs, Hungary. AD - National Laboratory on Human Reproduction, University of Pecs, 7623 Pecs, Hungary. AD - Molecular Medicine Research Group, Szentagothai Research Centre, University of Pecs, 7623 Pecs, Hungary. LA - eng PT - Journal Article DEP - 20260526 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 935E97BOY8 (Folic Acid) RN - N91BDP6H0X (Choline) RN - P6YC3EG204 (Vitamin B 12) RN - AE28F7PNPL (Methionine) RN - 3SCV180C9W (Betaine) SB - IM MH - Humans MH - Female MH - *Fertilization in Vitro MH - Pregnancy MH - Infant, Newborn MH - Adult MH - Folic Acid/administration & dosage/blood MH - *Birth Weight MH - Choline/administration & dosage MH - Vitamin B 12/blood/administration & dosage MH - *Maternal Nutritional Physiological Phenomena MH - *Dietary Supplements MH - Methionine/administration & dosage MH - Betaine/administration & dosage MH - Pregnancy Trimester, Third MH - Diet PMC - PMC13259345 OTO - NOTNLM OT - choline OT - folic acid OT - in vitro fertilization OT - methyl-group donor OT - newborn COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/06/12 06:38 MHDA- 2026/06/15 11:35 PMCR- 2026/05/26 CRDT- 2026/06/12 01:11 PHST- 2026/03/20 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/05/23 00:00 [accepted] PHST- 2026/06/15 11:35 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - nu18111693 [pii] AID - nutrients-18-01693 [pii] AID - 10.3390/nu18111693 [doi] PST - epublish SO - Nutrients. 2026 May 26;18(11):1693. doi: 10.3390/nu18111693. PMID- 42280306 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 22 TI - GLP-1 Receptor Agonists and Dual GIP/GLP-1 Receptor Agonists in Children and Adolescents with Obesity: Clinical Outcomes and the Impact of Nutritional and Behavioral Co-Interventions-A Systematic Review. LID - 10.3390/nu18111662 [doi] LID - 1662 AB - Introduction: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), originally developed for the treatment of type 2 diabetes (T2D), are increasingly used for the management of overweight and obesity in children and adolescents. However, the impact of concomitant lifestyle interventions, which vary in scope, structure, and intensity, remains unclear. Methods: A systematic search of PubMed, Scopus, and ClinicalTrials.gov was conducted from April to December 2025 (last update: 12 December 2025), in accordance with the PRISMA 2020 statement. Randomized and observational studies including patients aged 6-19 years with overweight or obesity, with or without T2D, treated with GLP-1 RAs or dual GIP/GLP-1 agonists, were included. Anthropometric outcomes, metabolic parameters, and the scope and structure of concomitant nutritional and behavioral interventions were assessed. Results: Fifteen studies (12 interventional [RCT/non-RCT] and 3 observational), including 1448 participants, were analyzed: liraglutide (n = 6), exenatide (n = 5), semaglutide (n = 1), dulaglutide (n = 1), tirzepatide (n = 1), and lixisenatide (n = 1). Intervention duration ranged from 6 to 68 weeks. Reported BMI reductions varied across studies and pharmacological agents, with semaglutide trials reporting reductions of up to -16.1%. Lifestyle interventions were heterogeneously reported, ranging from general dietary advice to structured, multidisciplinary programs including nutritional counseling, physical activity, and behavioral or family support. Due to heterogeneity in study design and reporting, the independent contribution of lifestyle interventions could not be determined. Conclusions: Available evidence suggests that GLP-1 RAs may represent an effective therapeutic option for children and adolescents with obesity and metabolic disorders. However, available evidence is largely derived from studies incorporating inconsistently reported lifestyle interventions, limiting the ability to disentangle pharmacological and lifestyle effects. Standardized reporting and studies specifically designed to assess their independent and combined effects are needed. Future research should standardize the reporting of lifestyle protocols (e.g., using TIDieR), incorporate validated measures of eating behavior, food preferences, and dietary intake, and use designs (e.g., factorial or stratified randomization of lifestyle intensity) that allow for the pharmacological and behavioral contributions to be quantified separately. This review highlights a critical and previously underexplored methodological gap regarding the structure and reporting of lifestyle co-interventions in pediatric GLP-1 trials. FAU - Mysliwczyk, Dominika AU - Mysliwczyk D AUID- ORCID: 0009-0004-2331-4106 AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, Marii Sklodowskiej-Curie 3a, 80-210 Gdansk, Poland. FAU - Gofron, Krzysztof Ksawery AU - Gofron KK AD - Student Scientific Circle at Department of Clinical Nutrition, Medical University of Gdansk, Marii Sklodowskiej-Curie 3a, 80-210 Gdansk, Poland. FAU - Wasilewski, Andrzej AU - Wasilewski A AUID- ORCID: 0000-0001-9908-6921 AD - Student Scientific Association of Medical Chemistry and Immunochemistry, Wroclaw Medical University, Marii Sklodowskiej-Curie 48/50, 59-369 Wroclaw, Poland. FAU - Mysliwiec, Malgorzata AU - Mysliwiec M AUID- ORCID: 0000-0002-1533-8544 AD - Department of Pediatrics, Diabetology and Endocrinology, Medical University of Gdansk, Marii Sklodowskiej-Curie 3a, 80-210 Gdansk, Poland. FAU - Wasilewska, Eliza AU - Wasilewska E AUID- ORCID: 0000-0002-5288-0586 AD - Department of Allergology, Medical University of Gdansk, Marii Sklodowskiej-Curie 3a, 80-210 Gdansk, Poland. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260522 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - WTT295HSY5 (dulaglutide) RN - 9P1872D4OL (Exenatide) RN - 59392-49-3 (Gastric Inhibitory Polypeptide) RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) RN - 62340-29-8 (Glucagon-Like Peptides) RN - 839I73S42A (Liraglutide) RN - 74O62BB01U (lixisenatide) RN - 53AXN4NNHX (Semaglutide) RN - OYN3CCI6QE (Tirzepatide) RN - 0 (Immunoglobulin Fc Fragments) RN - 0 (Recombinant Fusion Proteins) RN - 89750-14-1 (Glucagon-Like Peptide 1) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Young Adult MH - *Behavior Therapy MH - Exenatide/therapeutic use MH - *Gastric Inhibitory Polypeptide/agonists MH - *Glucagon-Like Peptide-1 Receptor Agonists/therapeutic use MH - Glucagon-Like Peptides/analogs & derivatives/therapeutic use MH - Life Style MH - Liraglutide/therapeutic use MH - *Pediatric Obesity/therapy/drug therapy MH - Semaglutide/therapeutic use MH - Tirzepatide/therapeutic use MH - Treatment Outcome MH - Immunoglobulin Fc Fragments MH - Recombinant Fusion Proteins MH - Glucagon-Like Peptide 1/analogs & derivatives PMC - PMC13258732 OTO - NOTNLM OT - GLP-1 receptor agonists OT - adolescents OT - children OT - dulaglutide OT - exenatide OT - lifestyle intervention OT - liraglutide OT - nutritional counseling OT - pediatric obesity OT - semaglutide OT - systematic review OT - tirzepatide COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/13 00:38 PMCR- 2026/05/22 CRDT- 2026/06/12 01:11 PHST- 2026/04/14 00:00 [received] PHST- 2026/05/20 00:00 [revised] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/13 00:38 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - nu18111662 [pii] AID - nutrients-18-01662 [pii] AID - 10.3390/nu18111662 [doi] PST - epublish SO - Nutrients. 2026 May 22;18(11):1662. doi: 10.3390/nu18111662. PMID- 42280305 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 11 DP - 2026 May 22 TI - Methodological Approaches to Assess Disordered Eating Behaviors Related to Gluten-Free Diet Management in Children and Adolescents with Celiac Disease: A Scoping Review. LID - 10.3390/nu18111661 [doi] LID - 1661 AB - Objective: This scoping review aimed to map the methodological approaches used to assess disordered eating attitudes and behaviors in children and adolescents with celiac disease (CD). Methods: This review followed the Joanna Briggs Institute scoping review methodology and the PRISMA-ScR guidelines, including studies of children and adolescents with CD that used methodological approaches to assess disordered eating attitudes and behaviors in the context of the gluten-free diet (GFD). No restrictions were applied regarding geography, language, or year. Searches were conducted across 10 electronic databases. Data were descriptively analyzed and presented in tables or diagrams, with a narrative synthesis aligned to the review objective. Results: Studies from 13 countries were included and classified as quantitative (n = 16; 51.6%), qualitative (n = 11; 35.5%), or mixed-methods (n = 4; 12.9%). A total of 34 instruments were used, but only one was specifically designed to evaluate eating attitudes and behaviors in children and adolescents with CD. Conclusions: Analysis of disordered eating in children and adolescents with CD remains methodologically heterogeneous and evolving. Quantitative studies predominate but often rely on non-specific instruments that blur the distinction between adaptive dietary vigilance and disordered eating. Qualitative and mixed-methods approaches highlight lived experiences and reveal measurement gaps despite their higher costs. Progress depends on developing specific instruments for this population that better capture the complexity of GFD management across development. FAU - Schwantes, Marina de Cesaro AU - Schwantes MC AD - Department of Nutrition, Faculty of Health Sciences, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Dusi, Rafaella AU - Dusi R AD - Department of Nutrition, Faculty of Health Sciences, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Uenishi, Rosa Harumi AU - Uenishi RH AUID- ORCID: 0000-0002-2352-4355 AD - Interdisciplinary Laboratory of Biosciences, Faculty of Medicine, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Ribeiro, Camila Dos Santos AU - Ribeiro CDS AUID- ORCID: 0000-0002-2770-1603 AD - Department of Nutrition, Faculty of Health Sciences, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Zandonadi, Renata Puppin AU - Zandonadi RP AUID- ORCID: 0000-0003-0370-3089 AD - Department of Nutrition, Faculty of Health Sciences, Darcy Ribeiro University Campus, University of Brasilia, Brasilia 70910-900, Brazil. LA - eng GR - 00193-00000325/2026-83/Foundation for Research Support of the Federal District/ PT - Journal Article PT - Scoping Review DEP - 20260522 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Diet, Gluten-Free/psychology MH - *Celiac Disease/diet therapy/psychology MH - Adolescent MH - Child MH - *Feeding and Eating Disorders/diagnosis/psychology/etiology MH - *Feeding Behavior/psychology MH - Female MH - Male MH - Adolescent Behavior MH - Child Behavior PMC - PMC13258312 OTO - NOTNLM OT - behavioral nutrition OT - disordered eating OT - gluten-free diet OT - psychometrics COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:38 MHDA- 2026/06/13 06:38 PMCR- 2026/05/22 CRDT- 2026/06/12 01:11 PHST- 2026/04/14 00:00 [received] PHST- 2026/05/18 00:00 [revised] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/06/13 06:38 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 01:11 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - nu18111661 [pii] AID - nutrients-18-01661 [pii] AID - 10.3390/nu18111661 [doi] PST - epublish SO - Nutrients. 2026 May 22;18(11):1661. doi: 10.3390/nu18111661. PMID- 42279021 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 11 DP - 2026 May 28 TI - The ALT/AST Ratio as a Predictor of MASLD in Obese Children: A Comparative Analysis with Metabolic Indices Including HOMA-IR and TyG. LID - 10.3390/jcm15114160 [doi] LID - 4160 AB - Background/Objectives: Metabolic dysfunction-associated steatotic liver disease (MASLD) is getting more prevalent in children with obesity, and simple and non-invasive biomarkers are needed for early detection. In this study, the discriminative performance of the ALT/AST ratio (AT index) for MASLD was evaluated in comparison with metabolic indices such as HOMA-IR and TyG derivatives. Methods: A total of 410 children with obesity aged 5-18 years were included in this prospective, multicenter cross-sectional study. Anthropometric measurements, laboratory data, and abdominal ultrasonography findings of the participants were evaluated. MASLD was diagnosed based on ultrasonographic findings. The discriminative performance of the indices was evaluated using ROC analysis, and factors independently associated with MASLD were assessed using multivariate logistic regression analysis. Results: BMI SDS, ALT, AT index, insulin, HOMA-IR, and TyG/ALT values were found to be significantly higher in the MASLD (+) group (p < 0.05). The AT index demonstrated statistically significant but modest discriminative ability for MASLD (AUC = 0.621; p < 0.001) and showed 70.5% sensitivity and 50.7% specificity at a cutoff value of >0.88. In the multivariate analysis, the AT index (OR: 3.401; 95% CI: 1.717-6.735; p < 0.001) and BMI SDS were identified as factors independently associated with MASLD.HOMA-IR and prolactin-related indices were not found to be significant as independent predictors. Conclusions: The ALT/AST ratio is a simple and accessible biomarker associated with MASLD in children with obesity. Although its discriminative performance is modest, its association with hepatic involvement and metabolic dysfunction suggests that it may provide supportive exploratory information in the evaluation of MASLD. However, further validation studies are required before broader clinical application. FAU - Kabukcu, Hilmi Onur AU - Kabukcu HO AUID- ORCID: 0000-0001-6869-9397 AD - Department of Pediatrics, Private Kastamonu Anatolia Hospital, 37200 Kastamonu, Turkey. FAU - Hazer, Ilhan AU - Hazer I AD - Department of Pediatric Endocrinology, Kutahya Health Sciences University, 43100 Kutahya, Turkey. LA - eng PT - Journal Article DEP - 20260528 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13257721 OTO - NOTNLM OT - AT index OT - MASLD OT - non-invasive biomarker COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:38 MHDA- 2026/06/12 06:39 PMCR- 2026/05/28 CRDT- 2026/06/12 01:06 PHST- 2026/05/06 00:00 [received] PHST- 2026/05/24 00:00 [revised] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/06/12 06:39 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 01:06 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - jcm15114160 [pii] AID - jcm-15-04160 [pii] AID - 10.3390/jcm15114160 [doi] PST - epublish SO - J Clin Med. 2026 May 28;15(11):4160. doi: 10.3390/jcm15114160. PMID- 42278890 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 11 DP - 2026 May 22 TI - Cardiovascular Risk and Modifiable Risk Factors in Shift-Working Healthcare Workers: A Gender-Stratified Cross-Sectional Study. LID - 10.3390/jcm15114028 [doi] LID - 4028 AB - Background: Shift-working healthcare workers (HCWs) are at elevated cardiovascular (CV) risk due to chronic circadian disruption; however, gender-stratified data on CV risk profiles and modifiable risk factor distribution by occupational exposure duration remain scarce in the Italian hospital setting. This cross-sectional study aimed to characterise the 10-year CV risk profile and the distribution of modifiable risk factors in a hospital-based sample of shift-working HCWs. Methods: A retrospective cross-sectional study was conducted using data from routine occupational health surveillance of shift-working HCWs at a large Italian hospital in Salento, Southern Italy (survey year: 2025). The 10-year CV risk was estimated using the CUORE Project algorithm, validated for the Italian population. Risk was stratified by gender, age group, and shift work duration. Multivariable logistic regression models, adjusted for age, marital status, and presence of children at home, evaluated associations between selected risk factors and CV risk category. The study was reported in accordance with STROBE guidelines. Results: Of 765 HCWs included (320 males, 445 females; mean age 49.3 +/- 8.5 years), male workers showed a significantly higher mean 10-year CV risk score (4.98 +/- 2.8 vs. 1.34 +/- 0.9; p < 0.05). Among male workers, the odds of moderate/high CV risk increased progressively with shift work duration (aOR 6.4 for >30 years). Males also showed significantly higher prevalence of arterial hypertension, overweight, and obesity across all strata. Conclusions: Male shift-working HCWs represent a higher-risk subgroup, characterised by a greater burden of modifiable cardiovascular risk factors. Integration of validated risk assessment tools into occupational health surveillance may support targeted preventive strategies in hospital settings. FAU - d'Ettorre, Gabriele AU - d'Ettorre G AUID- ORCID: 0000-0001-8714-1612 AD - Department of Occupational Medicine, Local Health Authority of Lecce, 73100 Lecce, Italy. FAU - Giannelli, Gianmarco AU - Giannelli G AD - Department of Occupational Medicine, Local Health Authority of Lecce, 73100 Lecce, Italy. FAU - Branda, Francesco AU - Branda F AUID- ORCID: 0000-0002-9485-3877 AD - Unit of Medical Statistics and Molecular Epidemiology, University Campus Bio-Medico of Rome, 00128 Rome, Italy. FAU - Loiacono, Giuseppe AU - Loiacono G AD - Department of Occupational Medicine, Local Health Authority of Lecce, 73100 Lecce, Italy. FAU - Calcagnile, Gianluigi AU - Calcagnile G AD - Department of Occupational Medicine, Local Health Authority of Lecce, 73100 Lecce, Italy. FAU - Centonze, Anna A AU - Centonze AA AD - Department of Occupational Medicine, Local Health Authority of Lecce, 73100 Lecce, Italy. FAU - Faggiano, Danilo AU - Faggiano D AD - Department of Occupational Medicine, Local Health Authority of Lecce, 73100 Lecce, Italy. FAU - d'Ettorre, Gabriella AU - d'Ettorre G AUID- ORCID: 0000-0002-3571-5677 AD - Department of Public Health and Infectious Diseases, University of Rome Sapienza, 00185 Rome, Italy. FAU - Ceccarelli, Giancarlo AU - Ceccarelli G AUID- ORCID: 0000-0001-5921-3180 AD - Department of Public Health and Infectious Diseases, University of Rome Sapienza, 00185 Rome, Italy. LA - eng PT - Journal Article DEP - 20260522 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13258224 OTO - NOTNLM OT - Italy OT - cardiovascular risk OT - cross-sectional study OT - healthcare workers OT - shift work COIS- The authors declare no conflicts of interest. EDAT- 2026/06/12 06:39 MHDA- 2026/06/12 06:40 PMCR- 2026/05/22 CRDT- 2026/06/12 01:06 PHST- 2026/04/13 00:00 [received] PHST- 2026/05/16 00:00 [revised] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/12 06:40 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 01:06 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - jcm15114028 [pii] AID - jcm-15-04028 [pii] AID - 10.3390/jcm15114028 [doi] PST - epublish SO - J Clin Med. 2026 May 22;15(11):4028. doi: 10.3390/jcm15114028. PMID- 42278755 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 11 DP - 2026 May 28 TI - Iterative Adaptations in a Physical Activity Program for Children with Autism: A Feasibility and Implementation Study. LID - 10.3390/healthcare14111502 [doi] LID - 1502 AB - Background: Children and adolescents with autism spectrum disorder (ASD) are generally more sedentary and engage less in physical activity (PA) than their peers. Despite increasing evidence of benefits, practical guidance on implementing adapted PA programs in real-world settings remains limited. This study aimed to document iterative adaptations, implementation processes, and participant experiences in a structured PA intervention for children with ASD. Methods: Nineteen children aged 10-14 years with ASD participated in an adapted PA intervention delivered across three cohorts. The program was progressively modified based on observed barriers and participant feedback. Post-intervention conversations with participants and/or parents were used to assess feasibility and experiences. Results: Most participants trained on-site in small groups and were predominantly boys, many with comorbid ADHD/ADD. Baseline engagement in organized PA was low. Adaptations included adjustments to session structure, group size, instructor-to-participant ratio, and activity content to enhance predictability and autonomy. Individual tailoring and flexible delivery were essential to accommodate neurodevelopmental diversity and fluctuating motivation. Post-intervention feedback suggested generally positive acceptability, while findings should be interpreted descriptively. Conclusions: This study provides preliminary, practice-based insights into how structured PA programs may be iteratively adapted for children with ASD in a supportive clinical context. The findings highlight practical considerations for implementing adapted PA in clinical and community settings. FAU - Richter, Miriam AU - Richter M AD - Division of Clinical Neurophysiology, Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden. AD - Division of Child and Adolescent Psychiatry, Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden. AD - Clinical Neurophysiology, Department of Medical Imaging and Physiology, Skane University Hospital, SE-221 85 Lund, Sweden. FAU - Taylor, Marie K AU - Taylor MK AUID- ORCID: 0000-0001-9391-1070 AD - Division of Clinical Neurophysiology, Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden. AD - Clinical Neurophysiology, Department of Medical Imaging and Physiology, Skane University Hospital, SE-221 85 Lund, Sweden. AD - Epilepsy Center, Department of Clinical Sciences, Lund University, SE-221 85 Lund, Sweden. FAU - Lindstedt, Teresa AU - Lindstedt T AD - Division of Pediatrics, Skane University Hospital, SE-221 84 Lund, Sweden. FAU - Lundkvist Josenby, Annika AU - Lundkvist Josenby A AUID- ORCID: 0000-0001-9694-9349 AD - Division of Pediatrics, Skane University Hospital, SE-221 84 Lund, Sweden. AD - Department of Health Sciences, Lund University, SE-221 85 Lund, Sweden. FAU - Rask, Olof AU - Rask O AUID- ORCID: 0000-0003-0565-3812 AD - Division of Child and Adolescent Psychiatry, Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden. FAU - Ekdahl, Christine T AU - Ekdahl CT AUID- ORCID: 0000-0002-1894-1955 AD - Division of Clinical Neurophysiology, Department of Clinical Sciences, Lund University, SE-221 84 Lund, Sweden. AD - Clinical Neurophysiology, Department of Medical Imaging and Physiology, Skane University Hospital, SE-221 85 Lund, Sweden. AD - Epilepsy Center, Department of Clinical Sciences, Lund University, SE-221 85 Lund, Sweden. LA - eng GR - Tore Nilsson Stiftelse for Medicinsk forskning/ GR - RSID 130567/Swedish medical ALF grant/ PT - Journal Article DEP - 20260528 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13256154 OTO - NOTNLM OT - adapted physical activity OT - autism spectrum disorder OT - feasibility study OT - implementation OT - physical activity COIS- The authors declare no conflict of interest. EDAT- 2026/06/12 06:38 MHDA- 2026/06/12 06:39 PMCR- 2026/05/28 CRDT- 2026/06/12 01:05 PHST- 2026/04/02 00:00 [received] PHST- 2026/05/16 00:00 [revised] PHST- 2026/05/23 00:00 [accepted] PHST- 2026/06/12 06:39 [medline] PHST- 2026/06/12 06:38 [pubmed] PHST- 2026/06/12 01:05 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - healthcare14111502 [pii] AID - healthcare-14-01502 [pii] AID - 10.3390/healthcare14111502 [doi] PST - epublish SO - Healthcare (Basel). 2026 May 28;14(11):1502. doi: 10.3390/healthcare14111502. PMID- 42277916 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260818 LR - 20260819 IS - 2055-5784 (Print) IS - 2055-5784 (Electronic) IS - 2055-5784 (Linking) VI - 12 IP - 1 DP - 2026 Jun 11 TI - Protocol for the Southeast Asian Healthy Habits, Healthy Kids (SEAHK) study, a culturally tailored family-based pilot randomized controlled trial to improve dietary quality. LID - 10.1186/s40814-026-01863-1 [doi] LID - 118 AB - BACKGROUND: Southeast Asian (SEA) children are burdened by high rates of diet-related chronic conditions and diseases. These burdens partly result from socioeconomic disadvantages and refugee migration trajectories. Yet, to our knowledge, no dietary interventions exist for this population. This protocol paper describes the rationale, study design, intervention and study evaluation for the SEA Healthy Habits, Healthy Kids Study. METHODS: The study enrollment goal was 75 parent-child dyads recruited in Providence, Rhode Island, in the United States. A SEA parent/guardian and one of their 6-to-11-year-old children were randomized to (1) a monthly financial incentive only group; (2) an enhanced financial incentive group that receives additional interventions including family-based group nutrition education, three motivational interviewing (MI) phone calls, and weekly text messages on healthy eating norms and other nutrition topics; or (3) a structurally equivalent attention-matched control group. The primary study goals were to assess feasibility and acceptability, conduct process evaluation to determine implementation fidelity and intervention dose, and determine preliminary efficacy. Feasibility was assessed based on attendance (primary) and secondary measures, recruitment, enrollment, intervention dose, and retention at 6 months. Acceptability was measured using satisfaction questionnaires on study favorability. Preliminary efficacy (i.e., comparing changes in children's diet quality (Healthy Eating Index and dermal carotenoids)) will be determined via longitudinal mixed effects models. Regression models will investigate the relationship between dose, implementation measures and study outcomes. RESULTS: This intervention received Institutional Review Board approval on February 16, 2023. We conducted intervention development from July 2022 to August 2022 with 62 SEA parents and children. For the intervention, we began participant recruitment in April 2023, which concluded January 2025. DISCUSSION: This study will demonstrate whether a culturally tailored healthy eating intervention for SEA families is feasible and acceptable and whether it leads to changes on key efficacy indicators. The intervention is informed by theories and frameworks relevant for the population and utilizes a family-centered approach. If this innovative pilot intervention achieves the study objectives, then we will refine it and pursue a larger randomized control trial. TRIAL REGISTRATION: This study is registered at ClinicalTrials.gov under registration number NCT05817838. The trial was registered on April 17, 2023. The trial registry record is available at https://clinicaltrials.gov/study/NCT05817838 . CI - (c) 2026. The Author(s). FAU - Dulin, Akilah AU - Dulin A AUID- ORCID: 0000-0002-0769-1014 AD - Department of Social, Behavioral and Population Sciences, Tulane University, Celia Scott Weatherhead School of Public Health, 1400 Canal St, New Orleans, LA, 70112, USA. adulin@tulane.edu. FAU - Tovar, Alison AU - Tovar A AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, 02903, USA. FAU - Dunsiger, Shira AU - Dunsiger S AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, 02903, USA. AD - Department of Biostatistics, Brown University School of Public Health, Providence, RI, 02903, USA. FAU - Carey, Kate B AU - Carey KB AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, RI, 02903, USA. FAU - Gans, Kim M AU - Gans KM AD - Department of Biostatistics, Brown University School of Public Health, Providence, RI, 02903, USA. AD - Department of Human Development and Family Sciences, University of Connecticut, Storrs, CT, 06269, USA. LA - eng SI - ClinicalTrials.gov/NCT05817838 GR - R01 DK128197/DK/NIDDK NIH HHS/United States GR - 5R01DK128197/DK/NIDDK NIH HHS/United States GR - 5R01DK128197/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20260611 PL - England TA - Pilot Feasibility Stud JT - Pilot and feasibility studies JID - 101676536 PMC - PMC13479714 OTO - NOTNLM OT - Diet OT - Family OT - Intervention study OT - Southeast Asian people OT - Type 2 diabetes COIS- Declarations. Ethics approval and consent to participate : This study received approval from the Brown University Institutional Review Board (protocol 2022003499). All adult participants provided informed consent (verbal or written) and children provided assent to participate. Consent for publication: This is included as part of the participant consent and assent forms. Competing interests : The authors declare that they do not have any financial competing interests in the study. Author AD is a long-time board member of the community partner organization where the study is occurring, and has provided continuous, in-kind support for the past 12 years. EDAT- 2026/06/12 06:39 MHDA- 2026/06/12 06:40 PMCR- 2026/06/11 CRDT- 2026/06/12 00:57 PHST- 2025/01/12 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/06/12 06:40 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 00:57 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - 10.1186/s40814-026-01863-1 [pii] AID - 1863 [pii] AID - 10.1186/s40814-026-01863-1 [doi] PST - epublish SO - Pilot Feasibility Stud. 2026 Jun 11;12(1):118. doi: 10.1186/s40814-026-01863-1. PMID- 42277719 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260909 IS - 1471-2334 (Electronic) IS - 1471-2334 (Linking) VI - 26 IP - 1 DP - 2026 Jun 11 TI - Machine learning-based prediction of bronchiolitis in children under two years: a multicenter study within a single metropolitan area. LID - 10.1186/s12879-026-13802-9 [doi] LID - 1516 AB - BACKGROUND: Bronchiolitis is a leading cause of hospitalization in infants, yet early and accurate risk prediction remains a clinical challenge. Traditional models often lack the complexity to capture nonlinear interactions or the transparency required for clinical trust. OBJECTIVE: This multicenter study aimed to develop, validate, and interpret machine learning (ML) models for predicting bronchiolitis risk in children under two years of age using clinical and socioeconomic determinants. METHODS: In this retrospective study, data from 1,260 children (529 with bronchiolitis and 731 without) were collected at 5 pediatric centers within a single metropolitan area, from January 2023 through December 2024. Seventeen predictors were analyzed. After rigorous preprocessing and K-NN imputation, eight ML algorithms, including four base learners and four ensemble methods, were developed. Model performance was evaluated using AUC and metrics derived from confusion matrices. Clinical utility was assessed via Decision Curve Analysis (DCA) and calibration plots. Explainable AI (XAI) was implemented using Shapley Additive exPlanations (SHAP) to interpret model decisions. RESULTS: XGBoost achieved an AUC of 0.863 [0.828-0.897] in the test set, demonstrating higher predictive performance than base learners such as NB (AUC: 0.583 [0.529-0.638]). DCA and calibration plots confirmed that XGBoost provides superior net benefit and calibration performance across a range of threshold probabilities. SHAP analysis identified overcrowding, severe acute malnutrition, and maternal smoking as the most influential predictors, highlighting the critical role of socioeconomic and environmental factors in disease susceptibility. CONCLUSION: The integration of XGBoost with SHAP values provides a robust, transparent, and clinically actionable framework for early prediction of bronchiolitis based on variables available at initial clinical presentation. By identifying high-risk infants through interpretable AI, this model supports early triage and optimized resource allocation, fostering the transition toward precision pediatric medicine. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2026. The Author(s). FAU - Nopour, Raoof AU - Nopour R AUID- ORCID: 0000-0003-3770-2375 AD - Social Determinants of Health Research Center, Semnan University of Medical Sciences, Semnan, Iran. nopour.r70@gmail.com. FAU - Barzegari, Saeed AU - Barzegari S AD - Department of Paramedicine, Amol School of Paramedical Sciences, Mazandaran University of Medical Sciences, Sari, Iran. FAU - Shanbehzadeh, Mostafa AU - Shanbehzadeh M AD - Department of Health Information Technology, School of Allied Medical Sciences, Ilam University of Medical Sciences, Ilam, Iran. FAU - Mahmoudvand, Zahra AU - Mahmoudvand Z AD - Department of Health Information Technology, School of Allied Medical Sciences, Mazandaran University of Medical Sciences, Sari, Iran. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260611 PL - England TA - BMC Infect Dis JT - BMC infectious diseases JID - 100968551 SB - IM MH - Humans MH - *Bronchiolitis/diagnosis/epidemiology MH - Retrospective Studies MH - Infant MH - *Machine Learning MH - Predictive Learning Models MH - Female MH - Boosting Machine Learning Algorithms MH - Male MH - Prediction Algorithms MH - Classification Algorithms MH - Infant, Newborn MH - Hospitalization MH - Algorithms PMC - PMC13483499 OTO - NOTNLM OT - Bronchiolitis OT - Explainable AI OT - Machine learning OT - Pediatric triage OT - SHAP OT - Socioeconomic determinants OT - XGBoost COIS- Declarations. Ethics approval and consent to participate: This study was approved by the ethics committee of the Mazandaran University of Medical Sciences (IR.MAZUMS.REC.1405.023). Ethical approval was obtained from the investigators' affiliated institution (Mazandaran University of Medical Sciences), although data collection was conducted at collaborating pediatric centers in Tehran. All methods were carried out in accordance with relevant guidelines and regulations. Informed consent was obtained from all subjects and/or their legal guardian(s). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/12 06:39 MHDA- 2026/08/19 14:49 PMCR- 2026/06/11 CRDT- 2026/06/12 00:47 PHST- 2026/04/29 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/08/19 14:49 [medline] PHST- 2026/06/12 06:39 [pubmed] PHST- 2026/06/12 00:47 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - 10.1186/s12879-026-13802-9 [pii] AID - 13802 [pii] AID - 10.1186/s12879-026-13802-9 [doi] PST - epublish SO - BMC Infect Dis. 2026 Jun 11;26(1):1516. doi: 10.1186/s12879-026-13802-9. PMID- 42275809 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260901 IS - 1873-4898 (Electronic) IS - 1477-5131 (Linking) VI - 22 IP - 5 DP - 2026 Oct TI - Quality of life and gender identity in females with congenital adrenal hyperplasia after genital restoration surgery: A single-center experience. PG - 106051 LID - S1477-5131(26)00330-X [pii] LID - 10.1016/j.jpurol.2026.106051 [doi] AB - BACKGROUND: Legislation restricting surgical interventions in children with differences of sex development (DSD) has intensified debate about female genital restoration surgery (FGRS) in patients with congenital adrenal hyperplasia (CAH). Long-term patient-reported outcomes are needed regarding the optimal timing of surgery. OBJECTIVE: We aimed to assess health-related quality of life (HRQoL), gender identity, and family satisfaction regarding surgical timing and outcome in females with CAH following genital restoration surgery. STUDY DESIGN: Cross-sectional survey of CAH patients who underwent surgery between January 2007 to December 2016 at our institution. Validated instruments (KINDL questionnaire for HRQoL, Utrecht Gender Dysphoria Scale, UGDS) and structured telephone interviews were employed. RESULTS: Data on HRQoL was available for 25 patients (self- and/or parent-reported) out of 56 eligible patients (45% response rate). Median age at first surgery was 6 months (range: 3-137 months). Patients' age at time of participation ranged from 2 to 28 years. All had 21-hydroxylase deficiency (92% salt-wasting form) with Prader grades ranging from II-V. Wound dehiscence requiring secondary suturing occurred in 15% of patients with primary surgery at our center, while only one (4%) patient developed vaginal stenosis after early primary vaginoplasty. Two additional patients (8%) with prior outside surgery required vaginal revision after FGRS at age 12. HRQoL scores were comparable to healthy reference populations across most age groups. Children aged 3-6 and adolescents and young adults showed no significant difference from reference values, while children aged 7-13 showed a slight elevation. None of five patients >/=14 years demonstrated gender dysphoria (all UGDS scores <40, threshold >/=40). 14 patients and families were also interviewed by telephone. All preferred early surgical timing. No family expressed regret about the decision or preferred delayed surgery. DISCUSSION: This study provides validated intermediate-term patient- and parent-reported outcomes after FGRS in CAH. Key limitations include the small sample size, single-center design, and young age of most patients. Selection bias may exist, though participating families included those who underwent revision surgery. The absence of a non-operated comparison group reflects current clinical reality, as nearly all CAH patients with urogenital sinus underwent surgical correction. CONCLUSIONS: Females with CAH reported normal HRQoL and a comfortable female gender identity after early FGRS. The patients and their families expressed a preference for early surgery. However, there is need for longer-term follow-up to assess sexual function and reproductive outcomes as well comparison of outcomes with a non-operated group. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Heidtmann, Friederike AU - Heidtmann F AD - Department of Pediatric Surgery, Jena University Hospital, 07747 Jena, Germany. Electronic address: friederike.heidtmann@med.uni-jena.de. FAU - Umbreit, Saskia AU - Umbreit S AD - Department of Pediatric Surgery, Jena University Hospital, 07747 Jena, Germany. Electronic address: saskia.umbreit@live.de. FAU - Eckoldt, Felicitas AU - Eckoldt F AD - Department of Pediatric Surgery, Jena University Hospital, 07747 Jena, Germany. Electronic address: felicitas.eckoldt@med.uni-jena.de. LA - eng PT - Journal Article DEP - 20260530 PL - England TA - J Pediatr Urol JT - Journal of pediatric urology JID - 101233150 SB - IM MH - Humans MH - Female MH - *Adrenal Hyperplasia, Congenital/surgery/psychology MH - Cross-Sectional Studies MH - Child MH - *Quality of Life MH - Adolescent MH - Child, Preschool MH - Adult MH - *Gender Identity MH - Young Adult MH - Infant MH - *Genitalia, Female/surgery MH - Gender Dysphoria MH - Treatment Outcome MH - *Plastic Surgery Procedures/methods MH - Retrospective Studies OTO - NOTNLM OT - Congenital adrenal hyperplasia OT - Female genital restoration surgery OT - Gender dysphoria OT - Patient reported outcomes OT - Quality of life OT - Urogenital sinus COIS- Conflict of interest statement None. EDAT- 2026/06/12 00:37 MHDA- 2026/09/01 05:41 CRDT- 2026/06/11 18:04 PHST- 2026/01/14 00:00 [received] PHST- 2026/04/26 00:00 [revised] PHST- 2026/05/23 00:00 [accepted] PHST- 2026/09/01 05:41 [medline] PHST- 2026/06/12 00:37 [pubmed] PHST- 2026/06/11 18:04 [entrez] AID - S1477-5131(26)00330-X [pii] AID - 10.1016/j.jpurol.2026.106051 [doi] PST - ppublish SO - J Pediatr Urol. 2026 Oct;22(5):106051. doi: 10.1016/j.jpurol.2026.106051. Epub 2026 May 30. PMID- 42275593 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2359-4292 (Electronic) IS - 2359-3997 (Print) IS - 2359-3997 (Linking) VI - 70 IP - 4 DP - 2026 Jun 10 TI - Age-related changes in METS-IR and HOMA-IR in obese adults and their relationship with cardiometabolic comorbidities. LID - 10.20945/2359-4292-2026-0059 [doi] LID - e260059 AB - OBJECTIVE: Insulin resistance (IR) is central to cardiometabolic risk in obesity, but the clinical utility of IR indices may vary by age. We compared homeostasis model assessment for insulin resistance (HOMA-IR) and metabolic score for insulin resistance (METS-IR) across age groups in obese adults and examined comorbidity burden and discriminatory performance for type 2 diabetes mellitus (T2DM) and hypertension (HT). SUBJECTS AND METHODS: This retrospective, single-center study included adults with a BMI >/= 30 kg/m2 (n = 481) across four age strata (18-40, 40-65, 65-75, and >/=75 years). Spearman correlation assessed the association between HOMA-IR and METS-IR. Comorbidity burden (0-3 chronic conditions) was modeled using ordinal logistic regression per 1-SD increase in z-scores, adjusted for age, sex, and BMI. Receiver operating characteristic analysis and multivariable logistic regression assessed T2DM and HT. RESULTS: HOMA-IR and METS-IR were moderately correlated (rho = 0.342 and p < 0.001, respectively). METS-IR was associated with comorbidity burden (adjusted odds ratio [OR] 1.84; 95% confidence interval [CI] 1.26-2.69; p < 0.01), whereas HOMA-IR was not (OR 1.12; 95% CI 0.92-1.36; p = 0.256). Discriminatory performance was limited for T2DM (area under curve [AUC] 0.500 vs. 0.537) and HT (AUC 0.471 vs. 0.519). METS-IR remained associated with T2DM (OR 2.51; 95% CI 1.60-3.93; p < 0.001) and HT (OR 1.81; 95% CI 1.13-2.91; p < 0.05). CONCLUSION: In obese adults, METS-IR demonstrated a stronger association with comorbidity burden than HOMA-IR. However, because both indices showed limited discriminatory performance for T2DM and HT, they should not be used as standalone tools for treatment guidance or diagnostic classification. Rather, they should be interpreted alongside age, clinical, and biochemical findings, as isolated use may be misleading and fail to identify disease in specific patient subgroups. FAU - Timurkaan, Esra Suay AU - Timurkaan ES AUID- ORCID: 0000-0001-5654-7070 AD - Department of Internal Medicine Clinic, Fethi Sekin City Hospital, Elazig, Turkey. FAU - Altuntas, Gulsum AU - Altuntas G AUID- ORCID: 0000-0002-2673-8594 AD - Department of Intensive Care Clinic, Firat University, Elazig, Turkey. FAU - Uslu, Muhammed Fuad AU - Uslu MF AUID- ORCID: 0000-0001-6300-5130 AD - Department of Internal Medicine Clinic, Fethi Sekin City Hospital, Elazig, Turkey. FAU - Ayyildiz, Hakan AU - Ayyildiz H AUID- ORCID: 0000-0002-3133-9862 AD - Department of Internal Medicine Clinic, Fethi Sekin City Hospital, Elazig, Turkey. FAU - Timurkaan, Mustafa AU - Timurkaan M AUID- ORCID: 0000-0003-1950-0489 AD - Department of Internal Medicine Clinic, Fethi Sekin City Hospital, Elazig, Turkey. LA - eng PT - Journal Article DEP - 20260610 PL - Brazil TA - Arch Endocrinol Metab JT - Archives of endocrinology and metabolism JID - 101652058 SB - IM MH - Humans MH - Female MH - *Insulin Resistance/physiology MH - Male MH - Retrospective Studies MH - *Obesity/metabolism/complications/epidemiology MH - Middle Aged MH - *Diabetes Mellitus, Type 2/epidemiology/metabolism MH - Aged MH - Adult MH - Comorbidity MH - Age Factors MH - *Hypertension/epidemiology/metabolism MH - *Metabolic Syndrome/epidemiology/metabolism MH - Young Adult MH - Adolescent MH - Body Mass Index MH - Homeostasis PMC - PMC13327391 OTO - NOTNLM OT - HOMA-IR OT - METS-IR OT - comorbidity burden. OT - insulin resistance OT - obesity COIS- Disclosure: no potential conflict of interest relevant to this article was reported. EDAT- 2026/06/11 18:35 MHDA- 2026/06/13 00:38 PMCR- 2026/06/08 CRDT- 2026/06/11 15:26 PHST- 2026/06/13 00:38 [medline] PHST- 2026/06/11 18:35 [pubmed] PHST- 2026/06/11 15:26 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - 10.20945/2359-4292-2026-0059 [doi] PST - epublish SO - Arch Endocrinol Metab. 2026 Jun 10;70(4):e260059. doi: 10.20945/2359-4292-2026-0059. PMID- 42275010 OWN - NLM STAT- Publisher LR - 20260611 IS - 2168-3824 (Electronic) IS - 0270-1367 (Linking) DP - 2026 Jun 11 TI - Examining Native Hawaiian and Pacific Islander Youth Attitudes Toward Physical Activity and Physical Education. PG - 1-8 LID - 10.1080/02701367.2026.2676647 [doi] AB - Native Hawaiian and Pacific Islander (NHPI) populations experience persistent disparities in physical activity (PA) and chronic disease, however, little is known about NHPI youths affective orientations toward PA and physical education (PE). The purpose of this study was to examine NHPI youths' attitudes toward PA and PE and their associations with intentions and behavior. Participants included 1,163 students in grades 4-12 from 11 schools (5 elementary, 6 secondary) across 2 islands in Hawai'i, with 57% identifying as NHPI. Students completed validated measures of PA attitudes, PE attitudes, PA intention, and self-reported PA. No differences emerged between NHPI and non-NHPI students across attitudes, intentions, or PA behavior. Within NHPI youth, positive PA attitudes were significantly associated with both PA intention and behavior, whereas PE attitudes were not. Findings challenge deficit-based assumptions that NHPI youth possess negative orientations toward PA. Instead, NHPI youth demonstrate positive PA attitudes that appear to operate independently of school-based PE experiences. This study contributes to the literature by highlighting the importance of distinguishing PA and PE attitudes within TPB-informed research and by underscoring the need for culturally responsive approaches that sustain positive PA dispositions across development. FAU - Hafoka, Crystal K AU - Hafoka CK AD - University of Hawai'i at Manoa. FAU - Centeio, Erin E AU - Centeio EE AUID- ORCID: 0000-0001-5465-4243 AD - University of Hawai'i at Manoa. FAU - Simonton, Kelly L AU - Simonton KL AUID- ORCID: 0000-0001-7261-2047 AD - University of Wyoming. FAU - Serna, A Ku'ulei AU - Serna AK AUID- ORCID: 0000-0001-9991-3544 AD - University of Hawai'i at Manoa. FAU - Mercier, Kevin J AU - Mercier KJ AUID- ORCID: 0000-0003-3505-2495 AD - Adelphi University. LA - eng PT - Journal Article DEP - 20260611 PL - United States TA - Res Q Exerc Sport JT - Research quarterly for exercise and sport JID - 8006373 SB - IM OTO - NOTNLM OT - Attitudes OT - Native Hawaiian and Pacific Islander Youth OT - culture OT - physical activity EDAT- 2026/06/11 12:38 MHDA- 2026/06/11 12:38 CRDT- 2026/06/11 11:33 PHST- 2026/06/11 12:38 [medline] PHST- 2026/06/11 12:38 [pubmed] PHST- 2026/06/11 11:33 [entrez] AID - 10.1080/02701367.2026.2676647 [doi] PST - aheadofprint SO - Res Q Exerc Sport. 2026 Jun 11:1-8. doi: 10.1080/02701367.2026.2676647. PMID- 42274851 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 7 DP - 2026 Jun 11 TI - Incidence and associated factors of metachronous contralateral cryptorchidism after unilateral cryptorchidism: a retrospective cohort study. LID - 486 [pii] LID - 10.1007/s00431-026-07154-4 [doi] AB - Acquired cryptorchidism is an increasingly recognized condition and may present bilaterally with a metachronous pattern. The objective of this study was to evaluate the incidence of acquired contralateral metachronous cryptorchidism and to identify associated factors in patients undergoing surgery for unilateral cryptorchidism. This retrospective cohort descriptive study included patients who underwent surgery for unilateral cryptorchidism in the Paediatric Surgery departments of Consorci Sanitari Alt Penedes-Garraf and Hospital Universitari Mutua Terrassa between 2005 and 2024. Demographic data, characteristics of cryptorchidism, and intraoperative findings from the initial surgery were recorded. A history of prematurity and obesity were also collected. A total of 275 patients were included. Contralateral acquired cryptorchidism developed in 11 of 111 patients with congenital cryptorchidism (9.9%; 95% CI 5.1%-17%) and in 29 of 164 patients with acquired cryptorchidism (17.7%; 95% CI 12.2%-24.4%). Multivariate analysis identified the following associated factors for metachronous contralateral cryptorchidism: acquired cryptorchidism at initial presentation (aOR = 4.00, 95% CI 1.60-9.99; p = 0.003), persistence of the processus vaginalis on the initially operated side (aOR = 5.94, 95% CI 2.44-14.48; p < 0.001) and prematurity (aOR = 6.38, 95% CI 1.75-23.25; p = 0.005). CONCLUSION: The overall incidence of metachronous cryptorchidism in patients with unilateral disease was 15%. A higher incidence was observed among patients with acquired cryptorchidism than among those with congenital cryptorchidism, although this difference did not reach statistical significance. These findings suggest that periodic follow-up until adolescence may be warranted in patients with unilateral cryptorchidism, particularly in those with acquired forms. Patients with congenital cryptorchidism require periodic follow-up until adolescence, while those with acquired unilateral cryptorchidism should be carefully monitored before surgery to detect bilateral involvement and allow simultaneous treatment. WHAT IS KNOWN: * Cryptorchidism affects 1-4% of full-term newborns, with long-term consequences for fertility and testicular cancer risk. Acquired cryptorchidism, the ascent of a previously descended testis, accounts for more than half of all cases. * The risk factors for metachronous contralateral cryptorchidism after unilateral disease remain poorly characterized, and no consensus exists on the appropriate follow-up strategy for these patients. WHAT IS NEW: * Metachronous contralateral cryptorchidism occurred in 15% of patients. The incidence was higher in patients with acquired cryptorchidism than in those with congenital cryptorchidism althouh the difference was not statistically significant. Persistence of the processus vaginalis at the time of surgery on the first side, and prematurity were other associated factors. * Prospective studies are needed to validate these associated factors and to determine whether active observation before surgery enables earlier detection of bilateral disease and synchronous orchidopexy. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Grande-Moreillo, C AU - Grande-Moreillo C AUID- ORCID: 0000-0002-8243-777X AD - Paediatric Surgery Unit Consorci Sanitari Alt Penedes I Garraf, Ronda de Sant Camil S/N. 08810, Sant Pere de Ribes, Spain. cgrande@csapg.cat. AD - Department of Paediatric Surgery Hospital, Universitari Mutua Terrassa, Placa Doctor Robert, 5. 08221, Terrassa, Spain. cgrande@csapg.cat. FAU - Perez-Lopez, C AU - Perez-Lopez C AUID- ORCID: 0000-0001-7400-4360 AD - Research Area, Consorci Sanitari Alt Penedes I Garraf, Ronda de Sant Camil S/N. 08810, Sant Pere de Ribes, Spain. FAU - Vicente-Sanchez, N AU - Vicente-Sanchez N AUID- ORCID: 0009-0001-7878-6918 AD - Department of Paediatric Surgery Hospital, Universitari Mutua Terrassa, Placa Doctor Robert, 5. 08221, Terrassa, Spain. FAU - Fuentes-Carretero, S AU - Fuentes-Carretero S AUID- ORCID: 0000-0002-0285-681X AD - Department of Paediatric Surgery Hospital, Universitari Mutua Terrassa, Placa Doctor Robert, 5. 08221, Terrassa, Spain. LA - eng PT - Journal Article DEP - 20260611 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Cryptorchidism/surgery/epidemiology MH - Male MH - Retrospective Studies MH - Incidence MH - Risk Factors MH - Infant MH - Child, Preschool MH - Infant, Newborn MH - Child OTO - NOTNLM OT - Acquired cryptorchidism OT - Cryptorchidism OT - Follow-up studies OT - Metachronous disease OT - Paediatrics OT - Undescended testis COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. The protocol was approved by the Research Ethics Committee of Hospital Universitari de Bellvitge (ref. PR030/24). Due to the retrospective nature of the study, informed consent was waived. Competing interests: The authors declare no competing interests. EDAT- 2026/06/11 12:41 MHDA- 2026/06/13 00:39 CRDT- 2026/06/11 11:17 PHST- 2026/02/09 00:00 [received] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/05/20 00:00 [revised] PHST- 2026/06/13 00:39 [medline] PHST- 2026/06/11 12:41 [pubmed] PHST- 2026/06/11 11:17 [entrez] AID - 10.1007/s00431-026-07154-4 [pii] AID - 10.1007/s00431-026-07154-4 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jun 11;185(7):486. doi: 10.1007/s00431-026-07154-4. PMID- 42274442 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260804 IS - 1878-2620 (Electronic) IS - 1499-4046 (Linking) VI - 58 IP - 8 DP - 2026 Aug TI - Creation and Psychometric Evaluation of the Teen Moms Child Feeding Readiness to Change Questionnaire for Teenage Mothers in Rural Suburbs of Nigeria. PG - 770-784 LID - S1499-4046(26)00125-9 [pii] LID - 10.1016/j.jneb.2026.05.001 [doi] AB - OBJECTIVE: To develop and validate the Teen Moms Child Feeding Readiness to Change Questionnaire for Sub-Saharan Africa for evaluating the transtheoretical stages of behavioral change related to infant and young child feeding. DESIGN: Cross-sectional study. SETTING: Communities with populations with low income in rural suburban areas of Abuja, Nigeria. PARTICIPANTS: Ten nutrition experts and 156 teenage mothers. METHODS: Nineteen items were generated on a 5-point Likert scale for responses. Two questions were eliminated after content evaluation by a panel of 10 nutrition experts and comprehensibility assessment by 6 teenage mothers. Unidimensionality and internal consistency reliability of the subscales were determined by factor loadings, Loevinger's scalability coefficient H and Molenaar Sijtsma rho coefficients. Construct validity was established via polytomous item response theory in 150 teenage mothers in rural suburbs of Abuja, Nigeria. RESULTS: The final questionnaire contained 11 questions in 3 subscales. All retained items had factor loadings > 0.4, Loevinger's coefficient H > 0.3, and rho coefficients > 0.6. All items displayed good discrimination (>/= 1) and difficulty parameters. Response characteristic curves indicated that the Likert option neither agree nor disagree was not frequently selected; thus, it was deleted. From scale information curves, it was observed that the contemplation, action, and maintenance subscales precisely estimated information for respondents with average ability to perform the latent construct. The precontemplation subscale contained more information for respondents with less than average abilities. CONCLUSIONS AND IMPLICATIONS: The Teen Moms Child Feeding Readiness to Change Questionnaire for Sub-Saharan Africa demonstrated promising preliminary evidence of validity and reliability for assessing Transtheoretical stages of change in teenage mothers. Further validation in larger and more diverse samples is warranted. CI - Copyright (c) 2026 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved. FAU - Sosanya, Mercy E AU - Sosanya ME AD - Department of Exercise and Nutrition Sciences, University at Buffalo, NY; Department of Nutrition and Dietetics, The Federal Polytechnic, Bauchi, Bauchi, Nigeria. Electronic address: mercysosanya@utexas.edu. FAU - Samuel, Temitope C AU - Samuel TC AD - Centre for Family Health Initiative, Abuja, Nigeria. FAU - Ugwu-Anyanwu, Krystal C AU - Ugwu-Anyanwu KC AD - Centre for Family Health Initiative, Abuja, Nigeria. FAU - Freeland-Graves, Jeanne H AU - Freeland-Graves JH AD - Department of Nutritional Sciences, University of Texas at Austin, Austin, TX. LA - eng PT - Journal Article PT - Validation Study DEP - 20260611 PL - United States TA - J Nutr Educ Behav JT - Journal of nutrition education and behavior JID - 101132622 SB - IM MH - Humans MH - Female MH - Nigeria MH - Adolescent MH - *Psychometrics MH - Surveys and Questionnaires/standards MH - Cross-Sectional Studies MH - Rural Population MH - Reproducibility of Results MH - *Adolescent Mothers/psychology/statistics & numerical data MH - Infant MH - *Feeding Behavior/psychology MH - Mothers OTO - NOTNLM OT - adolescent mothers OT - infant and young child feeding OT - psychometric validation OT - readiness to change OT - transtheoretical model EDAT- 2026/06/11 12:39 MHDA- 2026/08/09 15:17 CRDT- 2026/06/11 10:45 PHST- 2025/03/17 00:00 [received] PHST- 2026/04/09 00:00 [revised] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/08/09 15:17 [medline] PHST- 2026/06/11 12:39 [pubmed] PHST- 2026/06/11 10:45 [entrez] AID - S1499-4046(26)00125-9 [pii] AID - 10.1016/j.jneb.2026.05.001 [doi] PST - ppublish SO - J Nutr Educ Behav. 2026 Aug;58(8):770-784. doi: 10.1016/j.jneb.2026.05.001. Epub 2026 Jun 11. PMID- 42273503 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260611 LR - 20260813 IS - 2250-0685 (Print) IS - 2321-3817 (Electronic) IS - 2250-0685 (Linking) VI - 16 IP - 6 DP - 2026 Jun TI - Creatine Supplementation in Pediatric Orthopedic Rehabilitation: A Translational Review and Proposed Clinical Trial Framework. PG - 293-299 LID - 10.13107/jocr.2026.v16.i06.7450 [doi] AB - INTRODUCTION: Knee arthroscopy is a commonly performed minimally invasive orthopedic procedure in pediatric and adolescent populations, particularly for sports-related injuries such as ligament tears and meniscal pathology. Optimization of post-operative recovery is essential in this age group to preserve muscle mass, restore neuromuscular control, and facilitate safe return to activity during a critical period of musculoskeletal development. Perioperative nutritional strategies represent a modifiable adjunct to rehabilitation; however, their role in pediatric orthopedic recovery remains insufficiently defined. MATERIALS AND METHODS: This comprehensive narrative review synthesizes mechanistic, translational, and clinical literature on creatine supplementation to evaluate its potential role in enhancing post-operative recovery following pediatric and adolescent knee arthroscopy. Relevant literature was identified through structured searches of PubMed, Scopus, and Google Scholar, emphasizing adult orthopedic rehabilitation trials, experimental studies of skeletal muscle metabolism, perioperative nutrition research, and limited pediatric supplementation data. Although not conducted as a formal systematic review, a structured and targeted search strategy was used to enhance methodological rigor and reproducibility. RESULTS: Across adult surgical and immobilization models, creatine supplementation has demonstrated preservation of muscle mass, enhanced strength recovery, improved GLUT4-mediated glucose uptake, augmented glycogen storage, reduced inflammatory signaling, and attenuation of disuse-related muscle atrophy. Although direct pediatric surgical data are lacking, consistent mechanistic and clinical findings, combined with creatine's endogenous production and favorable safety profile in youth athletic populations, provide a biologically plausible rationale for investigation in pediatric orthopedic settings. CONCLUSION: The convergence of adult evidence and the absence of pediatric-specific clinical trials highlights a critical gap in the literature. Creatine supplementation represents a promising adjunct to post-operative rehabilitation following pediatric knee arthroscopy, warranting prospective clinical trials to determine its efficacy, safety, and optimal perioperative use. CI - Copyright: (c) Indian Orthopaedic Research Group. FAU - Hoffman, Isaiah D AU - Hoffman ID AD - College of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, California. FAU - Combs, Kristen AU - Combs K AD - Department of Orthopedic Surgery, Shriners Hospitals for Children, Pasadena, California. LA - eng PT - Journal Article PT - Review PL - India TA - J Orthop Case Rep JT - Journal of orthopaedic case reports JID - 101641392 PMC - PMC13248198 OTO - NOTNLM OT - Creatine supplementation OT - knee arthroscopy OT - muscle recovery OT - pediatric orthopedics OT - rehabilitation OT - sports medicine COIS- Conflict of Interest: Nil EDAT- 2026/06/11 06:37 MHDA- 2026/06/11 06:38 PMCR- 2026/06/01 CRDT- 2026/06/11 04:54 PHST- 2026/03/13 00:00 [received] PHST- 2026/04/03 00:00 [revised] PHST- 2026/06/11 06:38 [medline] PHST- 2026/06/11 06:37 [pubmed] PHST- 2026/06/11 04:54 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - JOCR-16-6-293 [pii] AID - 10.13107/jocr.2026.v16.i06.7450 [doi] PST - ppublish SO - J Orthop Case Rep. 2026 Jun;16(6):293-299. doi: 10.13107/jocr.2026.v16.i06.7450. PMID- 42273093 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260611 LR - 20260813 IS - 2223-4292 (Print) IS - 2223-4306 (Electronic) IS - 2223-4306 (Linking) VI - 16 IP - 6 DP - 2026 Jun 1 TI - Comparative study of Gd-EOB-DTPA-enhanced magnetic resonance imaging signal intensity parameters and albumin-bilirubin grade for liver function assessment based on early and middle-stage of liver dysfunction. PG - 456 LID - 10.21037/qims-2025-aw-2463 [doi] LID - 456 AB - BACKGROUND: Gadolinium-ethoxy benzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) enables not only liver lesion detection but also a one-stop assessment of hepatic function. Among the commonly used liver function scoring systems, the albumin-bilirubin (ALBI) grade is more objective than the Child-Turcotte-Pugh (CTP) grade and is particularly suitable for evaluating liver function in patients with early and middle-stage chronic liver disease. However, although various Gd-EOB-DTPA-enhanced MRI signal intensity (SI) parameters have been employed for liver function assessment, a comprehensive comparison of their efficacy is lacking, and no consensus exists on the optimal parameter. This study aimed to compare the efficacy of eight Gd-EOB-DTPA-enhanced MRI SI parameters in assessing liver function based on the ALBI grading system and identify the optimal imaging biomarker for clinical application. METHODS: A total of 99 high-risk patients with hepatitis B-related hepatocellular carcinoma (HCC) in the early or middle stages (61 with ALBI grade 1 and 38 with ALBI grades 2-3) underwent Gd-EOB-DTPA-enhanced MRI. Eight parameters were analyzed, including the relative enhancement rate of hepatic parenchyma, liver-muscle contrast ratio, liver-spleen contrast ratio, liver-portal vein contrast ratio, liver-muscle ratio growth rate, liver-spleen ratio growth rate, relative SI of biliary tract, and portal vein-spleen contrast ratio. Statistical analyses included receiver operating characteristic (ROC) curves evaluation, Spearman correlation, and independent-samples t-test to compare diagnostic performance and correlate parameters with ALBI scores. RESULTS: Liver-portal vein contrast ratio showed the numerically highest discriminative power for distinguishing ALBI grade 1 from grades 2-3 in all MRI parameters [area under the curve (AUC): 0.806, 95% confidence interval (CI): 0.715-0.897; sensitivity: 85.2%, specificity: 63.2%, cutoff value: 1.4763], followed by liver-spleen contrast ratio (AUC: 0.799, cutoff value: 1.7536) and relative enhancement rate of hepatic parenchyma (AUC: 0.765, cutoff value: 0.7874). Liver-muscle ratio growth rate exhibited moderate efficacy (AUC: 0.730, cutoff value: 0.9116). Parameters showed significant correlations with ALBI scores (|r|: 0.368-0.532, P<0.001), except for portal vein-spleen contrast ratio (r=0.116, P=0.253). The AUC of relative SI of biliary tract was 0.678. The cutoff value of relative SI of biliary tract was 4.3656. The assessment of portal vein-spleen contrast ratio did not show a significant association with functional differences (P=0.589). CONCLUSIONS: Liver-portal vein contrast ratio showed the numerically best performance among all MRI parameters for differentiating ALBI grades in this study population, offering superior sensitivity for early-stage liver dysfunction assessment. Gd-EOB-DTPA-enhanced MRI not only enables a more accurate prediction of postoperative functional liver reserve but also provides a comprehensive foundation for clinicians to formulate optimal, individualized treatment strategies, thereby potentially reducing the incidence of postoperative complications. Meanwhile, we caution against reliance on portal vein-spleen contrast ratio or biliary signal measurements. CI - (c) AME Publishing Company. FAU - Xia, Ruike AU - Xia R AD - Department of Nuclear Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. FAU - Wu, Xiaoxiao AU - Wu X AUID- ORCID: 0009-0007-2523-4849 AD - Medical Imaging College, Shanghai University of Medicine and Health Sciences, Shanghai, China. AD - School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China. FAU - Zheng, Jun AU - Zheng J AD - Department of Radiology, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. FAU - Wang, Xiaoyang AU - Wang X AD - Department of Nuclear Medicine, The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. FAU - Peng, Wenxian AU - Peng W AUID- ORCID: 0000-0001-9889-3537 AD - Medical Imaging College, Shanghai University of Medicine and Health Sciences, Shanghai, China. LA - eng PT - Journal Article DEP - 20260508 PL - China TA - Quant Imaging Med Surg JT - Quantitative imaging in medicine and surgery JID - 101577942 PMC - PMC13247879 OTO - NOTNLM OT - Gadolinium-ethoxy benzyl-diethylenetriamine penta-acetic acid (Gd-EOB-DTPA) OT - albumin-bilirubin grade (ALBI grade) OT - contrast-enhanced scan OT - liver function OT - magnetic resonance imaging (MRI) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://qims.amegroups.com/article/view/10.21037/qims-2025-aw-2463/coif). The authors have no conflicts of interest to declare. EDAT- 2026/06/11 06:39 MHDA- 2026/06/11 06:40 PMCR- 2026/06/01 CRDT- 2026/06/11 04:50 PHST- 2025/11/18 00:00 [received] PHST- 2026/04/03 00:00 [accepted] PHST- 2026/06/11 06:40 [medline] PHST- 2026/06/11 06:39 [pubmed] PHST- 2026/06/11 04:50 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - qims-16-06-456 [pii] AID - 10.21037/qims-2025-aw-2463 [doi] PST - ppublish SO - Quant Imaging Med Surg. 2026 Jun 1;16(6):456. doi: 10.21037/qims-2025-aw-2463. Epub 2026 May 8. PMID- 42272737 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260611 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Longitudinal analysis of behavioral addictions among children and adolescents in the context of the COVID-19 pandemic. PG - 1791527 LID - 10.3389/fpsyg.2026.1791527 [doi] LID - 1791527 AB - INTRODUCTION: Behavioral addictions in childhood and adolescence remain understudied, particularly beyond digital media use. The COVID-19 pandemic introduced substantial disruptions to youths' daily routines, social functioning, and emotional well-being, potentially increasing vulnerability to maladaptive behavioral patterns. This three-wave longitudinal study examined trajectories and correlates of gambling, shopping, exercise, and eating addiction symptoms among children and adolescents across the pandemic period. METHODS: The study included 1,665 Israeli students aged 9-16.7 years assessed before the COVID-19 pandemic (October 2019), after the first wave (November 2020), and after the fifth wave and return to regular schooling (April 2022). Participants completed validated measures of behavioral addiction symptoms, psychiatric symptoms, negative and positive affect, sensation seeking, life satisfaction, social support, secure attachment, hope, future orientation, grit, and gratitude. Structural equation modeling tested indirect effects of protective factors on behavioral addictions via risk factors at baseline, and linear growth-curve models estimated change in addiction symptoms over time. RESULTS: Symptoms of exercise, gambling, and shopping addictions increased significantly across the three time points, whereas eating addiction symptoms remained stable. Negative affect, psychiatric symptoms, and sensation seeking predicted higher levels of behavioral addiction, and social support was unexpectedly associated with higher exercise, gambling, and eating addiction symptoms. In contrast, future orientation, life satisfaction, hope, positive emotions, and secure attachment were linked to fewer symptoms. Protective factors were related to lower behavioral addiction symptoms only indirectly, through their associations with reduced negative affect and psychiatric symptoms, indicating full mediation. Girls reported more shopping and eating addiction symptoms, whereas boys reported more gambling and exercise symptoms; older age was linked to fewer shopping, exercise, and eating symptoms but more gambling symptoms. DISCUSSION: These findings suggest that youth behavioral addictions intensified during and after the pandemic, even when most symptoms remained subclinical. Emotional and social resources functioned as resilience factors primarily by shaping mental health, highlighting negative affect and psychiatric distress as key intervention targets to prevent behavioral addictions in children and adolescents. CI - Copyright (c) 2026 Farbstein-Yavin, Shoshani, Gvion and Kor. FAU - Farbstein-Yavin, Shaked AU - Farbstein-Yavin S AD - Department of Psychology, Bar-Ilan University, Ramat-Gan, Israel. FAU - Shoshani, Anat AU - Shoshani A AD - Baruch Ivcher School of Psychology, Reichman University, Herzliya, Israel. FAU - Gvion, Yari AU - Gvion Y AD - Department of Psychology, Bar-Ilan University, Ramat-Gan, Israel. FAU - Kor, Ariel AU - Kor A AD - Baruch Ivcher School of Psychology, Reichman University, Herzliya, Israel. LA - eng PT - Journal Article DEP - 20260526 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13246624 OTO - NOTNLM OT - COVID-19 pandemic OT - behavioral addictions OT - children and adolescents OT - developmental pathways OT - longitudinal study OT - risk and protective factors OT - youth mental health COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/11 06:35 MHDA- 2026/06/11 06:36 PMCR- 2026/05/26 CRDT- 2026/06/11 04:46 PHST- 2026/01/19 00:00 [received] PHST- 2026/04/21 00:00 [revised] PHST- 2026/04/23 00:00 [accepted] PHST- 2026/06/11 06:36 [medline] PHST- 2026/06/11 06:35 [pubmed] PHST- 2026/06/11 04:46 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1791527 [doi] PST - epublish SO - Front Psychol. 2026 May 26;17:1791527. doi: 10.3389/fpsyg.2026.1791527. eCollection 2026. PMID- 42272568 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260611 LR - 20260922 IS - 2472-1972 (Electronic) IS - 2472-1972 (Linking) VI - 10 IP - 7 DP - 2026 Jul TI - Feasibility, reproducibility, and cold-induced energy expenditure using whole-room calorimetry in adults and children. PG - bvag102 LID - 10.1210/jendso/bvag102 [doi] LID - bvag102 AB - CONTEXT: To understand energy balance, whole-room indirect calorimetry (WRIC) allows for accurate measurement of energy expenditure (EE). OBJECTIVE: To examine the relationship between cold-induced resting EE and brown adipose tissue (BAT) activity measured by magnetic resonance imaging (MRI) and to evaluate WRIC system (WRICS) performance and feasibility of use in children and adults. METHODS: The WRICS was equipped with a Promethion High-Definition Room Calorimetry System. Technical validation utilized nitrogen (N(2)) and carbon dioxide (CO(2)) gas infusions. Healthy adults (n = 21) and children aged 8-17 years (n = 17) attended two 4-hour WRIC visits (one week apart) and one MRI visit. Resting EE at 25 degrees C (REE(25)) was compared between visits and to REE at 18 degrees C (REE(18)). Recruitment and completion rates were examined. BAT activity was assessed by MRI as the decline in supraclavicular proton density fat fraction during 18 degrees C cold exposure. RESULTS: Gas infusion testing confirmed high accuracy (respiratory exchange ratio [RER] = 0.99; 95% CI 0.991-0.996). Study completion rates were high (adults: 20/21; children: 17/18). REE(25) over a 10-minute period was consistent between visits (adults: 1.68 +/- 0.462 vs 1.66 +/- 0.301 kcal/min, P = 0.77; children: 1.50 +/- 0.358 vs 1.58 +/- 0.348 kcal/min, P = .25). Cold exposure increased fasting EE by 0.21 kcal/min (adults) and 0.14 kcal/min (children). BAT activity was correlated with REE(18) in adults (r = 0.49, P = .04). CONCLUSION: WRICS use was feasible in adults and children. Changes in EE during cold (ie, cold-induced thermogenesis) were measurable and related to BAT activity, supporting the usefulness of this system in the assessment of EE in response to interventions in adults and children. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Endocrine Society. FAU - Cheveldayoff, Paige AU - Cheveldayoff P AUID- ORCID: 0000-0003-4907-3019 AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Department of Pediatrics, McMaster University, Hamilton, ON, Canada L8N 3Z5. FAU - Alamri, Bader AU - Alamri B AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Division of Endocrinology, Department of Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5. FAU - Wang, Dongdong AU - Wang D AUID- ORCID: 0000-0002-6195-4428 AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Division of Endocrinology, Department of Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5. FAU - Gonzalez, Rogelio Cruz AU - Gonzalez RC AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Department of Pediatrics, McMaster University, Hamilton, ON, Canada L8N 3Z5. FAU - Thomas, Aaron C Q AU - Thomas ACQ AUID- ORCID: 0009-0003-4985-586X AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Department of Pediatrics, McMaster University, Hamilton, ON, Canada L8N 3Z5. FAU - Konyer, Norm AU - Konyer N AD - Imaging Research Centre, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada L8P 3B7. FAU - Noseworthy, Michael D AU - Noseworthy MD AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Imaging Research Centre, St. Joseph's Healthcare Hamilton, Hamilton, ON, Canada L8P 3B7. AD - Electrical and Computer Engineering, McMaster University, Hamilton, ON, Canada L8N 3Z5. FAU - Gerstein, Hertzel C AU - Gerstein HC AUID- ORCID: 0000-0001-8072-2836 AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Division of Endocrinology, Department of Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5. FAU - Punthakee, Zubin AU - Punthakee Z AUID- ORCID: 0000-0003-4894-3617 AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Division of Endocrinology, Department of Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5. FAU - Steinberg, Gregory R AU - Steinberg GR AUID- ORCID: 0000-0001-5425-8275 AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Division of Endocrinology, Department of Medicine, McMaster University, Hamilton, ON, Canada L8N 3Z5. FAU - Morrison, Katherine M AU - Morrison KM AUID- ORCID: 0000-0002-1737-256X AD - Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, ON, Canada L8N 3Z5. AD - Department of Pediatrics, McMaster University, Hamilton, ON, Canada L8N 3Z5. LA - eng PT - Journal Article DEP - 20260505 PL - United States TA - J Endocr Soc JT - Journal of the Endocrine Society JID - 101697997 PMC - PMC13248870 OTO - NOTNLM OT - BAT activity OT - cold exposure OT - energy expenditure OT - indirect calorimetry OT - obesity OT - pediatrics EDAT- 2026/06/11 06:37 MHDA- 2026/06/11 06:38 PMCR- 2026/05/05 CRDT- 2026/06/11 04:44 PHST- 2025/09/16 00:00 [received] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/06/11 06:38 [medline] PHST- 2026/06/11 06:37 [pubmed] PHST- 2026/06/11 04:44 [entrez] PHST- 2026/05/05 00:00 [pmc-release] AID - bvag102 [pii] AID - 10.1210/jendso/bvag102 [doi] PST - epublish SO - J Endocr Soc. 2026 May 5;10(7):bvag102. doi: 10.1210/jendso/bvag102. eCollection 2026 Jul. PMID- 42271514 OWN - NLM STAT- MEDLINE DCOM- 20260816 LR - 20260825 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 27 IP - 1 DP - 2026 Jun 11 TI - Efficacy and safety of SarogLItazar as an add-on medication to Metformin and lifestyle intervention in women with PolyCystic Ovary Syndrome (SLIM-PCOS trial): study protocol for a randomized, open-label, parallel group clinical trial. LID - 10.1186/s13063-026-09534-5 [doi] LID - 532 AB - BACKGROUND: Emerging concepts on the role of insulin resistance (IR) in the pathogenesis of polycystic ovary syndrome (PCOS) have driven a shift in the therapeutic approach towards interventions targeting IR. SarogLItazar as an add-on to Metformin in PolyCystic Ovary Syndrome (SLIM-PCOS) trial aims to test the efficacy and safety of saroglitazar, a dual peroxisome proliferator-activated receptor (PPAR alpha/gamma) agonist belonging to "glitazar" class of drugs, on top of metformin and lifestyle intervention in PCOS. METHODS: SLIM-PCOS is an investigator-initiated, randomized, open label, parallel group, superiority, clinical trial. Around 140 PCOS patients will be randomized in 1:1 ratio to either of the two study groups: Group A: tablet saroglitazar (4 mg daily) + tablet metformin (500 mg twice daily) + lifestyle intervention; and Group B: tablet metformin + lifestyle intervention. Lifestyle intervention will comprise of dietary intervention and physical activity. Treatment will be given for 24 weeks and post-treatment follow up done at 36 weeks. The primary outcome is to compare the change in serum sex hormone binding globulin (SHBG) levels at 24 weeks from baseline between the two groups. Secondary efficacy outcomes include clinical (anthropometry, hirsutism, menstrual cycles); metabolic and gonadal parameters (lipid profile, IR, ovarian hormones and androgens, metabolic syndrome); hepatic steatosis on transabdominal scan and quality of life. Safety outcomes include patient reported adverse events, hematological and biochemical safety parameters. Data will be analysed as per intention to treat (ITT) principle using validated statistical software. Two-tailed P-value < 0.05 will be considered statistically significant. DISCUSSION: SLIM-PCOS trial will provide evidence on the potential therapeutic application of saroglitazar in PCOS. Based on the study outcomes and the drug's mechanism of action, future studies may be planned to investigate into the role of this novel glitazar in PCOS patients having diabetes, dyslipidemia, non-alcoholic fatty liver disease and other associated co-morbidities. TRIAL REGISTRATION: Prospectively registered with the Clinical Trials Registry of India (Trial ID: CTRI/2025/09/094653); registered September 12, 2025. https://ctri.nic.in/Clinicaltrials/rmaindet.php?trialid=142027&EncHid=25944.27666&modid=1&compid=19 . CI - (c) 2026. The Author(s). FAU - Mittal, Niti AU - Mittal N AD - Department of Pharmacology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences (PGIMS), Rohtak, Haryana, 124001, India. drnitimittal@uhsr.ac.in. FAU - Singhal, Savita AU - Singhal S AD - Department of Obstetrics & Gynecology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences (PGIMS), Rohtak, Haryana, 124001, India. FAU - Mittal, Rakesh AU - Mittal R AD - Department of Pharmacology, Pt. B.D. Sharma Postgraduate Institute of Medical Sciences (PGIMS), Rohtak, Haryana, 124001, India. LA - eng GR - HSCSIT/R&D/2025/1558/Haryana State Council for Science, Innovation and Technology, Government of Haryana/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20260611 PL - England TA - Trials JT - Trials JID - 101263253 RN - 9100L32L2N (Metformin) RN - 0 (Phenylpropionates) RN - E0YMX3S4JD (saroglitazar) RN - 0 (Hypoglycemic Agents) RN - 0 (PPAR-gamma Agonists) RN - 0 (PPAR alpha) RN - 0 (PPAR gamma) RN - 0 (Pyrroles) SB - IM MH - Humans MH - Female MH - *Metformin/adverse effects/therapeutic use/administration & dosage MH - *Polycystic Ovary Syndrome/therapy/diagnosis/blood/drug therapy/physiopathology MH - *Phenylpropionates/adverse effects/therapeutic use/administration & dosage MH - *Hypoglycemic Agents/adverse effects/therapeutic use MH - Treatment Outcome MH - Randomized Controlled Trials as Topic MH - Drug Therapy, Combination MH - Insulin Resistance MH - Adult MH - Time Factors MH - Young Adult MH - PPAR-gamma Agonists MH - Adolescent MH - PPAR alpha/agonists MH - *Risk Reduction Behavior MH - PPAR gamma/agonists MH - Life Style MH - Pyrroles PMC - PMC13480098 OTO - NOTNLM OT - Lifestyle intervention OT - Metformin OT - Polycystic ovary syndrome OT - Randomised trial OT - Saroglitazar OT - Study protocol COIS- Declarations. Ethics approval and consent to participate: This study is approved by the by Biomedical Research Ethics Committee of our institute vide letter no. BREC/25/278 dated 09.09.2025 in accordance with the ethical standards defined under Declaration of Helsinki and New Drugs and Clinical Trials Rules, 2019. Written informed consent will be obtained from all the participants before their inclusion in the study. The participants will be provided with detailed information regarding the purpose, procedures, potential risks, and benefits of the study, and their voluntary participation and right to withdraw at any time will be emphasized. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/11 06:39 MHDA- 2026/08/17 05:38 PMCR- 2026/06/11 CRDT- 2026/06/11 00:17 PHST- 2025/11/16 00:00 [received] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/08/17 05:38 [medline] PHST- 2026/06/11 06:39 [pubmed] PHST- 2026/06/11 00:17 [entrez] PHST- 2026/06/11 00:00 [pmc-release] AID - 10.1186/s13063-026-09534-5 [pii] AID - 9534 [pii] AID - 10.1186/s13063-026-09534-5 [doi] PST - epublish SO - Trials. 2026 Jun 11;27(1):532. doi: 10.1186/s13063-026-09534-5. PMID- 42271444 OWN - NLM STAT- MEDLINE DCOM- 20260816 LR - 20260819 IS - 1477-7525 (Electronic) IS - 1477-7525 (Linking) VI - 24 IP - 1 DP - 2026 Jun 10 TI - Predicting poor health-related quality of life among Chinese adolescents using explainable machine learning: the role of school adjustment, family context, and lifestyle factors. LID - 10.1186/s12955-026-02568-y [doi] LID - 105 AB - BACKGROUND: Adolescents' health-related quality of life (HRQoL) is influenced by multiple domains, including school, family, and individual lifestyle. However, evidence remains limited on accurately predicting adolescent HRQoL and identifying modifiable determinants. This study aimed to develop a machine-learning prediction model for adolescent HRQoL and to determine key contextual factors associated with low quality of life. METHODS: This cross-sectional study included 20,236 adolescents (51.71% female; mean age 15.97 years). HRQoL was assessed using the validated Quality of Life Scale for Children and Adolescents (QLSCA). Twenty predictors covering school adjustment, family characteristics, and health behaviours were entered into 9 machine-learning classifiers and logistic regression. Feature contributions were examined using permutation importance, partial dependence plots (PDPs), and SHapley Additive exPlanations (SHAP). Stratified analyses by sex and school stage were conducted to identify group-specific determinants. RESULTS: School adjustment was the primary predictor of HRQoL, with self-management and peer relations contributing most. Family factors ranked next, particularly more frequent exercise with parents, which was associated with higher HRQoL. Among lifestyle behaviours, higher physical activity and healthier dietary patterns were associated with better HRQoL, whereas excessive screen time was associated with poorer HRQoL. In stratified analyses, peer relations and physical activity were more influential among boys, while self-management, exercising with parents, and adequate sleep contributed more among girls. Middle school students showed more adverse associations with disruptive/antisocial behaviours and screen time, whereas high school students derived greater benefits from family interaction and health behaviours. CONCLUSIONS: Explainable machine-learning analyses highlight school adjustment as a central correlate of adolescent HRQoL, alongside family characteristics and health behaviours. These findings provide multidimensional evidence to support targeted interventions in educational, family, and public health settings to improve adolescents' HRQoL. CI - (c) 2026. The Author(s). FAU - Zhao, Liangyu AU - Zhao L AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Gao, Yan AU - Gao Y AD - School of Physical Education, Shandong University, Jinan, 250061, China. gaoyanluck@sdu.edu.cn. FAU - Liu, Chenchen AU - Liu C AD - School of Medical Information Engineering, Jining Medical University, Jining, 272067, China. FAU - Zhang, Zeqi AU - Zhang Z AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Yang, Yuke AU - Yang Y AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Hu, Yining AU - Hu Y AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Sui, Wenze AU - Sui W AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Ma, Sen AU - Ma S AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Zhang, Shuoqin AU - Zhang S AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Lai, Xinxin AU - Lai X AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Wang, Zhiying AU - Wang Z AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Yang, Zhiwen AU - Yang Z AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Yi, Xiangren AU - Yi X AD - School of Physical Education, Shandong University, Jinan, 250061, China. LA - eng GR - 21BTY054/National Social Science Fund of China/ GR - 2024YFC3607603/National Key Research and Development Program of China/ GR - 202409A07/National Population Health Data Center/ PT - Journal Article DEP - 20260610 PL - England TA - Health Qual Life Outcomes JT - Health and quality of life outcomes JID - 101153626 RN - Chinese people SB - IM MH - Humans MH - Female MH - Adolescent MH - *Quality of Life/psychology MH - Male MH - Cross-Sectional Studies MH - China MH - *Life Style MH - *Machine Learning MH - Health Behavior MH - Schools MH - East Asian People PMC - PMC13479416 OTO - NOTNLM OT - Adolescents OT - Family characteristics OT - Health-related quality of life OT - Healthy lifestyle OT - Machine learning OT - School adjustment COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Shandong University [Approval No. 20180517]. Adolescents and their parents/guardians gave informed consent prior to taking part in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/11 06:37 MHDA- 2026/08/17 05:38 PMCR- 2026/06/10 CRDT- 2026/06/11 00:14 PHST- 2026/02/06 00:00 [received] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/08/17 05:38 [medline] PHST- 2026/06/11 06:37 [pubmed] PHST- 2026/06/11 00:14 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.1186/s12955-026-02568-y [pii] AID - 2568 [pii] AID - 10.1186/s12955-026-02568-y [doi] PST - epublish SO - Health Qual Life Outcomes. 2026 Jun 10;24(1):105. doi: 10.1186/s12955-026-02568-y. PMID- 42271415 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260821 IS - 1750-1172 (Electronic) IS - 1750-1172 (Linking) VI - 21 IP - 1 DP - 2026 Jun 10 TI - The impacts of caring for children with inherited metabolic diseases for families: a cross-sectional study. LID - 10.1186/s13023-026-04434-y [doi] LID - 286 AB - BACKGROUND: Children with inherited metabolic diseases (IMDs) often have high care needs that require extensive involvement of family caregivers. This study aimed to describe caregiver experiences, including management of children's needs at home, and the impacts of that management on family time, finances, and caregiver and child health-related quality of life (HRQoL). METHODS: In this sub-study within a larger cohort study, participants were family caregivers of children /= 4 extra hours per week assisting their child with care supports at home and 28 reported >/= 6 missed days of work by caregivers in the past year for IMD care. All participants reported fulfillment from caregiving tasks, although 82% reported mental struggles related to caregiving. Based on caregiver reports, children with IMDs had lower HRQoL relative to population normative data. We observed lower median scores for several HRQoL subscales among children with IMDs classified as progressive with multi-system involvement relative to other IMDs. CONCLUSION: We identified important impacts of IMD care for family caregivers. Relief from high levels of caregiving responsibility and time should be a priority for the development of healthcare policies and interventions, to improve health and well-being for both children and their caregivers. CI - (c) 2026. The Author(s). FAU - Chow, Andrea J AU - Chow AJ AUID- ORCID: 0000-0003-1683-2912 AD - School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Crescent, Office 207C, Ottawa, ON, K1G 5Z3, Canada. FAU - Jordan, Isabel AU - Jordan I AD - Patient partner, Squamish, Canada. FAU - Pallone, Nicole AU - Pallone N AD - Patient Partner, Sparwood, Canada. FAU - Smith, Maureen AU - Smith M AUID- ORCID: 0000-0002-2885-7028 AD - Patient Partner, Ottawa, Canada. FAU - Chakraborty, Pranesh AU - Chakraborty P AD - Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Canada. FAU - Brehaut, Jamie AU - Brehaut J AD - Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, Canada. FAU - Chan, Alicia K J AU - Chan AKJ AD - Department of Medical Genetics, University of Alberta, Edmonton, Canada. FAU - Cohen, Eyal AU - Cohen E AUID- ORCID: 0000-0003-0112-7188 AD - Department of Pediatrics, University of Toronto, Hospital for Sick Children, Toronto, Canada. FAU - Dyack, Sarah AU - Dyack S AD - Department of Pediatrics, Dalhousie University, Halifax, Canada. FAU - Graham, Ian D AU - Graham ID AUID- ORCID: 0000-0002-3669-1216 AD - School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Crescent, Office 207C, Ottawa, ON, K1G 5Z3, Canada. AD - Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, Canada. FAU - Greenberg, Cheryl R AU - Greenberg CR AD - Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada. FAU - Hayeems, Robin AU - Hayeems R AD - Child Health Evaluative Sciences, University of Toronto, Hospital for Sick Children, Toronto, Canada. FAU - Inbar-Feigenberg, Michal AU - Inbar-Feigenberg M AUID- ORCID: 0000-0001-8128-5789 AD - Division of Clinical & Metabolic Genetics, The Hospital for Sick Children, Toronto, Canada. FAU - Jain-Ghai, Shailly AU - Jain-Ghai S AD - Department of Medical Genetics, University of Alberta, Edmonton, Canada. FAU - Khangura, Sara AU - Khangura S AUID- ORCID: 0000-0003-0094-6771 AD - School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Crescent, Office 207C, Ottawa, ON, K1G 5Z3, Canada. FAU - MacKenzie, Jennifer J AU - MacKenzie JJ AUID- ORCID: 0000-0002-3374-8619 AD - Department of Medicine, Queen's University, Kingston, Canada. FAU - Major, Nathalie AU - Major N AUID- ORCID: 0000-0003-3655-7460 AD - Department of Pediatrics, Children's Hospital of Eastern Ontario, Ottawa, Canada. FAU - Mitchell, John J AU - Mitchell JJ AD - Montreal Children's Hospital, Montreal, Canada. FAU - Nicholls, Stuart G AU - Nicholls SG AUID- ORCID: 0000-0003-0485-9069 AD - School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Crescent, Office 207C, Ottawa, ON, K1G 5Z3, Canada. AD - Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, Canada. AD - Office for Patient Engagement in Research Activities, Ottawa Hospital Research Institute, Ottawa, Canada. FAU - Pender, Amy AU - Pender A AD - Genetics & Metabolics Clinic, McMaster Children's Hospital, Hamilton, Canada. FAU - Potter, Murray AU - Potter M AUID- ORCID: 0000-0003-0577-362X AD - Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Canada. FAU - Prasad, Chitra AU - Prasad C AD - Department of Pediatrics, Western University, London, Canada. FAU - Schulze, Andreas AU - Schulze A AUID- ORCID: 0000-0001-8491-1095 AD - Division of Clinical & Metabolic Genetics, The Hospital for Sick Children, Toronto, Canada. AD - Department of Biochemistry, University of Toronto, Toronto, Canada. FAU - Siriwardena, Komudi AU - Siriwardena K AD - Department of Medical Genetics, University of Alberta, Edmonton, Canada. FAU - Speechley, Kathy N AU - Speechley KN AUID- ORCID: 0000-0002-5563-2377 AD - Department of Pediatrics, Western University, London, Canada. FAU - Stockler, Sylvia AU - Stockler S AUID- ORCID: 0000-0002-6542-423X AD - BC Children's Hospital, Vancouver, Canada. FAU - Taljaard, Monica AU - Taljaard M AD - Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, Canada. FAU - Trakadis, Yannis AU - Trakadis Y AD - Medical Genetics, Montreal Children's Hospital, Montreal, Canada. FAU - Walia, Jagdeep AU - Walia J AD - Department of Pediatrics, Queen's University, Kingston, Canada. FAU - Wilson, Kumanan AU - Wilson K AUID- ORCID: 0000-0002-1741-7705 AD - Methodological and Implementation Research, Ottawa Hospital Research Institute, Ottawa, Canada. AD - Department of Medicine, University of Ottawa, Ottawa, Canada. AD - Bruyere Health Research Institute, Ottawa, Canada. FAU - Potter, Beth K AU - Potter BK AUID- ORCID: 0000-0001-8374-6542 AD - School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Crescent, Office 207C, Ottawa, ON, K1G 5Z3, Canada. bpotter@uottawa.ca. LA - eng GR - PJT-153230/CAPMC/CIHR/Canada GR - PJT-153230/CAPMC/CIHR/Canada PT - Journal Article DEP - 20260610 PL - England TA - Orphanet J Rare Dis JT - Orphanet journal of rare diseases JID - 101266602 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Child MH - Female MH - Caregivers/psychology MH - Male MH - Quality of Life MH - *Metabolic Diseases MH - Surveys and Questionnaires MH - Child, Preschool MH - Adult MH - Infant PMC - PMC13487924 OTO - NOTNLM OT - Family-centred care OT - Healthcare management OT - Inherited metabolic diseases OT - Pediatrics OT - Rare diseases COIS- Declarations. Ethics approval and consent to participate: The study received ethics approval from the Children's Hospital of Eastern Ontario Research Ethics Board (CTO Project #1955), the University of Ottawa Research Ethics Board, and the Research Ethics Boards of the eleven participating centres. Written informed consent was obtained from all participants. Consent for publication: Not applicable. Competing interests: MIF has received: grant/research support from Sanofi Genzyme, Shire, Passage Bio, Ultragenyx pharmaceuticals, Denali Therapeutics Inc, Aeglea Biotherapeutics Inc, PTC Therapeutics, Moderna, Vtesse Inc. (Mallinckrodt Pharmaceuticals), conducted research (no funding) with the International Niemann Pick Disease Registry and the MLD Initiative; speaker honoraria from Horizon Therapeutics and the Canadian Fabry Disease Association; consulting fees from Shire, Sanofi Genzyme, Cyclo Therapeutics, and Simon Kutcher; and participated an advisory board of Horizon Therapeutics, Sanofi Genzyme, Shire, Ultragenyx Pharmaceuticals, Alexion Pharmaceuticals, and Recordati Rare Disease. JJ Mitchell has received: educational grants from Biomarin; consulting fees from Ultragenyx, PTC, Biomarin, Takeda, Sanofi, Beam Therapeutics, Moderna; and travel support from Biomarin. SGN received payment from the Health and Medical Research Fund of Hong Kong for peer review of a research study on the Views towards dried blood spot cards storage and its usage for extended genetic testing among parents and healthcare providers in Hong Kong. AP has participated in Dietitian advisory boards for: Ultragenyx (June 2024, April 2022 and March 2021) and Horizon (April 2022 and April 2021). MP is on the advisory board for Ultragenyx, PTC Therapeutics and BioMarin and is the clinical trial site-PI for PTC Therapeutics. KW is the co-founder of CANImmunize Inc and has previously served as a member of the independent safety advisory board for Moderna. The remaining authors have nothing to declare. EDAT- 2026/06/11 06:39 MHDA- 2026/08/19 14:48 PMCR- 2026/06/10 CRDT- 2026/06/11 00:12 PHST- 2025/12/09 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/08/19 14:48 [medline] PHST- 2026/06/11 06:39 [pubmed] PHST- 2026/06/11 00:12 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.1186/s13023-026-04434-y [pii] AID - 4434 [pii] AID - 10.1186/s13023-026-04434-y [doi] PST - epublish SO - Orphanet J Rare Dis. 2026 Jun 10;21(1):286. doi: 10.1186/s13023-026-04434-y. PMID- 42271315 OWN - NLM STAT- MEDLINE DCOM- 20260820 LR - 20260822 IS - 1471-2474 (Electronic) IS - 1471-2474 (Linking) VI - 27 IP - 1 DP - 2026 Jun 10 TI - Video-based gait analysis for clinical monitoring of genotype-specific functional patterns in osteogenesis imperfecta. LID - 10.1186/s12891-026-10056-z [doi] LID - 710 AB - BACKGROUND: Osteogenesis imperfecta (OI) is characterized by substantial genetic and functional heterogeneity, yet low-burden objective tools for repeated gait monitoring in routine outpatient care remain limited. This study investigated whether routine smartphone videos combined with markerless pose estimation could capture genotype-associated gait patterns in children with IFITM5- and WNT1-related OI, with COL1-related OI included as a cross-sectional reference cohort. METHODS: This single-center retrospective cohort study screened 237 pediatric patients with genetically confirmed IFITM5- or WNT1-related OI between 2014 and 2024. The main analytic cohort included 71 patients: 48 with IFITM5 mutations and 23 with WNT1 mutations. During the same period, 107 patients with COL1-related OI were screened, of whom 26 were included as a cross-sectional reference cohort. MediaPipe Pose was used to extract spatiotemporal and postural gait parameters from outpatient walking videos. Algorithmic consistency under simulated video perturbations was assessed, and gait phenotypes were evaluated using multivariable models, linear mixed-effects models, Kaplan-Meier analysis, and exploratory machine-learning analysis. RESULTS: Step_Width and Trunk_Lean showed high algorithmic consistency under perturbation testing, with ICC ranges of 0.966-0.980 and 0.923-0.983, respectively. At baseline, WNT1 patients showed greater Step_Width (0.265 +/- 0.073 vs. 0.203 +/- 0.062 m), Trunk_Lean (4.53 degrees +/- 2.10 degrees vs. 2.72 degrees +/- 1.63 degrees ), and Normalized_Step_Width (0.377 +/- 0.103 vs. 0.270 +/- 0.083) than IFITM5 patients (all P < 0.001). These differences remained after adjustment for age, sex, documented medication exposure, and surgical history, with adjusted differences of 0.046 m for Step_Width, 1.612 degrees for Trunk_Lean, and 0.087 for Normalized_Step_Width. In the COL1-related reference analysis, WNT1 patients retained higher Step_Width and Normalized_Step_Width than COL1-related OI patients, whereas Trunk_Lean did not differ significantly between these groups. Longitudinal analysis showed no significant age-related gait changes in the WNT1 group, whereas IFITM5 patients showed mild annual decreases in Step_Width (- 0.0026 m/year) and Normalized_Step_Width (- 0.0046/year). Surgery-free survival declined earlier in the WNT1 group than in the IFITM5 group (log-rank P = 0.007). The exploratory genotype classification model achieved an AUC of 0.804 (95% CI, 0.678-0.914). CONCLUSIONS: Routine outpatient smartphone videos combined with markerless pose estimation can capture genotype-associated gait patterns in pediatric OI. WNT1-related OI was characterized by a wider base of support and coronal-plane compensation, whereas IFITM5-related OI showed mild longitudinal changes in spatial gait metrics. Video-derived gait parameters may provide low-burden adjunctive measures for outpatient functional monitoring, although prospective reference-standard validation and larger multi-genotype cohorts are needed. CI - (c) 2026. The Author(s). FAU - Li, Yahao AU - Li Y AD - Suzhou Key Laboratory of Pediatric Hereditary Skeletal Diseases, Children's Hospital of Soochow University, Suzhou, Jiangsu, 215000, China. AD - Suzhou New Century Children's Hospital, Suzhou, Jiangsu, 215000, China. FAU - Yu, Sheng AU - Yu S AD - Suzhou Key Laboratory of Pediatric Hereditary Skeletal Diseases, Children's Hospital of Soochow University, Suzhou, Jiangsu, 215000, China. AD - Suzhou New Century Children's Hospital, Suzhou, Jiangsu, 215000, China. FAU - Sun, Qinglin AU - Sun Q AD - Suzhou Key Laboratory of Pediatric Hereditary Skeletal Diseases, Children's Hospital of Soochow University, Suzhou, Jiangsu, 215000, China. AD - Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, Jiangsu, 215025, China. AD - Suzhou New Century Children's Hospital, Suzhou, Jiangsu, 215000, China. FAU - Wang, Mingxing AU - Wang M AD - Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. FAU - Ren, Xiuzhi AU - Ren X AD - Suzhou Key Laboratory of Pediatric Hereditary Skeletal Diseases, Children's Hospital of Soochow University, Suzhou, Jiangsu, 215000, China. renxiuzhi7320@suda.edu.cn. AD - Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, Jiangsu, 215025, China. renxiuzhi7320@suda.edu.cn. FAU - Zhu, Zhenhong AU - Zhu Z AD - Suzhou Key Laboratory of Pediatric Hereditary Skeletal Diseases, Children's Hospital of Soochow University, Suzhou, Jiangsu, 215000, China. aman_zzh@126.com. AD - Children's Hospital of Soochow University, No. 92 Zhongnan Street, Suzhou, Jiangsu, 215025, China. aman_zzh@126.com. LA - eng GR - Szlcyxzxj202105/Suzhou Clinical Center for Rare Disease/ GR - SYW2025013/Suzhou Key Project of Applied Basic Research in Medical and Health/ PT - Journal Article DEP - 20260610 PL - England TA - BMC Musculoskelet Disord JT - BMC musculoskeletal disorders JID - 100968565 RN - 0 (Membrane Proteins) RN - 0 (IFITM5 protein, human) RN - 0 (Wnt1 Protein) RN - 0 (WNT1 protein, human) SB - IM MH - Humans MH - *Osteogenesis Imperfecta/genetics/physiopathology/diagnosis MH - Female MH - Retrospective Studies MH - Male MH - Membrane Proteins/genetics MH - *Gait Analysis/methods MH - *Video Recording/methods MH - Child MH - Mutation MH - Child, Preschool MH - Genotype MH - Wnt1 Protein/genetics MH - Cross-Sectional Studies MH - Adolescent MH - Phenotype MH - *Gait PMC - PMC13491806 OTO - NOTNLM OT - Genotype-phenotype correlation OT - Machine learning OT - Markerless gait analysis OT - Osteogenesis imperfecta COIS- Declarations. Ethics approval and consent to participate: The authors are accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved. The study was conducted in accordance with the Declaration of Helsinki (as revised in 2013). This study was approved by the Ethics Committee of the Children's Hospital of Soochow University (Approval No.: 2024CS146). Given the retrospective nature of the study and the use of anonymized data, the requirement for informed consent was waived by the Ethics Committee. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/11 06:37 MHDA- 2026/08/20 05:43 PMCR- 2026/06/10 CRDT- 2026/06/11 00:08 PHST- 2026/03/20 00:00 [received] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/08/20 05:43 [medline] PHST- 2026/06/11 06:37 [pubmed] PHST- 2026/06/11 00:08 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.1186/s12891-026-10056-z [pii] AID - 10056 [pii] AID - 10.1186/s12891-026-10056-z [doi] PST - epublish SO - BMC Musculoskelet Disord. 2026 Jun 10;27(1):710. doi: 10.1186/s12891-026-10056-z. PMID- 42270889 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1179-2019 (Electronic) IS - 1174-5878 (Print) IS - 1174-5878 (Linking) VI - 28 IP - 4 DP - 2026 Jul TI - Discontinuing Colchicine in Pediatric Familial Mediterranean Fever: Real-Life Experience from a Long-Term Follow-Up Cohort. PG - 405-415 LID - 10.1007/s40272-026-00755-4 [doi] AB - BACKGROUND: Colchicine is the cornerstone of treatment in familial Mediterranean fever and is generally recommended as lifelong therapy. However, a subset of pediatric patients may experience a milder disease course, raising questions about the feasibility and safety of colchicine discontinuation. Evidence guiding this decision remains limited, and no consensus exists on patient selection criteria or monitoring strategies. OBJECTIVE: The objective of this study was to evaluate long-term outcomes after colchicine discontinuation in a large pediatric familial Mediterranean fever cohort and to identify clinical and genetic factors associated with sustained colchicine-free remission. METHODS: We retrospectively analyzed medical records of 2316 pediatric patients diagnosed with familial Mediterranean fever and followed at the Pediatric Rheumatology Unit of Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkiye. Patients fulfilling at least one of the Tel-Hashomer or Eurofever/Pediatric Rheumatology International Trials Organization (PRINTO) classification criteria and carrying at least one pathogenic or likely pathogenic MEFV (Mediterranean fever) gene mutation were eligible. Colchicine was discontinued in 127 patients (5.48%), who were classified into two groups: Group 1 (n = 31), patients who required colchicine re-initiation because of recurrent attacks, and Group 2 (n = 96), patients who maintained sustained colchicine-free remission during follow-up. A contemporaneous comparator group of 118 patients who continued colchicine therapy without any attempt at discontinuation (Group 3) was included to provide clinical and genetic context. Demographic, clinical, genetic, and disease severity characteristics were compared across groups. RESULTS: Sustained colchicine-free remission was maintained in 96 of 2316 patients (4.14%; Group 2). Among all patients who discontinued colchicine (Groups 1 and 2 combined), the median duration of colchicine treatment before discontinuation was 3.85 years (interquartile range 1.84-7.10), and the median follow-up after cessation was 4.91 years (interquartile range 1.92-7.23). Baseline clinical, demographic, and genetic characteristics were largely similar between Group 1 and Group 2, and no robust independent predictor of sustained remission was identified. Biallelic pathogenic exon 10 MEFV variants were significantly more prevalent in Group 3 (32.2%) compared with Group 1 (12.9%) and Group 2 (3.1%), reflecting a progressive genetic gradient across the three groups. Patients in Group 3 also exhibited higher frequencies of fever, chest pain, arthritis, arthralgia, erysipelas-like erythema, and exercise-induced leg pain compared with the discontinuation groups. Fulfillment of Eurofever/PRINTO classification criteria was significantly lower in Groups 1 (54.8%) and 2 (54.2%) than in Group 3 (87.3%), consistent with a milder phenotypic profile in patients considered for discontinuation. No patient in the discontinuation cohort developed amyloidosis during follow-up. CONCLUSIONS: Colchicine discontinuation is achievable in a small but consistent subset of patients with pediatric familial Mediterranean fever (4.14% of the total cohort), the majority of whom maintain sustained remission over a long-term follow-up. While patients requiring continuous therapy exhibit a more severe clinical and genetic profile, no robust baseline predictor reliably distinguishes those who will remain in remission from those who will relapse. These findings highlight the need for individualized withdrawal decisions guided by rigorous longitudinal monitoring, and underscore the importance of prospective studies incorporating emerging biomarkers of subclinical inflammation. CI - (c) 2026. The Author(s). FAU - Arik, Selen Duygu AU - Arik SD AUID- ORCID: 0000-0001-7648-1195 AD - Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Turgut Ozal Millet Avenue, 118S, Emniyet-Fatih Metro Station, Istanbul, Turkey. FAU - Kayaalp, Gulsah Kavrul AU - Kayaalp GK AUID- ORCID: 0000-0001-7490-7076 AD - Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Turgut Ozal Millet Avenue, 118S, Emniyet-Fatih Metro Station, Istanbul, Turkey. FAU - Kilinc, Aysenur Dogru AU - Kilinc AD AUID- ORCID: 0000-0001-8091-8417 AD - Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Turgut Ozal Millet Avenue, 118S, Emniyet-Fatih Metro Station, Istanbul, Turkey. FAU - Menentoglu, Bengisu AU - Menentoglu B AUID- ORCID: 0000-0003-2774-9591 AD - Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Turgut Ozal Millet Avenue, 118S, Emniyet-Fatih Metro Station, Istanbul, Turkey. FAU - Taskin, Busra Baser AU - Taskin BB AUID- ORCID: 0009-0003-5097-4479 AD - Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Turgut Ozal Millet Avenue, 118S, Emniyet-Fatih Metro Station, Istanbul, Turkey. FAU - Dudakli, Asli AU - Dudakli A AUID- ORCID: 0000-0001-5454-0182 AD - Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Turgut Ozal Millet Avenue, 118S, Emniyet-Fatih Metro Station, Istanbul, Turkey. FAU - Tanatar, Ayse AU - Tanatar A AUID- ORCID: 0000-0002-1386-4575 AD - Department of Pediatric Rheumatology, Ministry of Health Marmara University, Pendik Training and Research Hospital, Istanbul, Turkey. FAU - Akgun, Ozlem AU - Akgun O AUID- ORCID: 0000-0001-7216-0562 AD - Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Turgut Ozal Millet Avenue, 118S, Emniyet-Fatih Metro Station, Istanbul, Turkey. FAU - Ayaz, Nuray Aktay AU - Ayaz NA AUID- ORCID: 0000-0003-3594-7387 AD - Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University, Turgut Ozal Millet Avenue, 118S, Emniyet-Fatih Metro Station, Istanbul, Turkey. nurayaktay@gmail.com. LA - eng PT - Journal Article DEP - 20260610 PL - Switzerland TA - Paediatr Drugs JT - Paediatric drugs JID - 100883685 RN - SML2Y3J35T (Colchicine) RN - 0 (Pyrin) RN - 0 (MEFV protein, human) SB - IM MH - Humans MH - *Colchicine/administration & dosage/therapeutic use MH - *Familial Mediterranean Fever/drug therapy/genetics MH - Female MH - Child MH - Retrospective Studies MH - Male MH - Follow-Up Studies MH - Adolescent MH - Child, Preschool MH - Pyrin/genetics MH - Mutation MH - Remission Induction MH - Treatment Interruption MH - Treatment Outcome PMC - PMC13379450 COIS- Declarations. Conflicts of Interest/Competing Interests: Selen Duygu Arik, Gulsah Kavrul Kayaalp, Aysenur Dogru Kilinc, Bengisu Menentoglu, Busra Baser Taskin, Asli Dudakli, Ayse Tanatar, Ozlem Akgun, and Nuray Aktay Ayaz have no conflicts of interest that are directly relevant to the content of this article. Ethics Approval: The study was approved by the Ethical Committee of Istanbul University, Istanbul Medicinal Faculty (date: 05.02.2024; No: 2405744). The study was carried out and complied with the Declaration of Helsinki. Consent to Participate: Written informed consent was obtained from all patients and/or their parents or legal guardians prior to inclusion in this study. Consent for Publication: Not applicable. Availability of Data and Material: The datasets generated and/or analyzed during the current study are available from the corresponding author on reasonable request. Code Availability: Not applicable. Authors' Contributions: All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by SDA, OA, and NAA. The first draft of the manuscript was written by SDA, and all authors commented on earlier versions. All authors read and approved the final manuscript. EDAT- 2026/06/11 05:43 MHDA- 2026/07/17 19:17 PMCR- 2026/06/10 CRDT- 2026/06/10 23:29 PHST- 2026/02/25 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/07/17 19:17 [medline] PHST- 2026/06/11 05:43 [pubmed] PHST- 2026/06/10 23:29 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.1007/s40272-026-00755-4 [pii] AID - 755 [pii] AID - 10.1007/s40272-026-00755-4 [doi] PST - ppublish SO - Paediatr Drugs. 2026 Jul;28(4):405-415. doi: 10.1007/s40272-026-00755-4. Epub 2026 Jun 10. PMID- 42270572 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260911 IS - 1473-2300 (Electronic) IS - 0300-0605 (Print) IS - 0300-0605 (Linking) VI - 54 IP - 6 DP - 2026 Jun TI - Evaluation of body mass index, waist-to-hip ratio, and waist-to-height ratio as predictors of insulin resistance in Syrian adult women: A cross-sectional study. PG - 3000605261455139 LID - 10.1177/03000605261455139 [doi] LID - 03000605261455139 AB - ObjectiveBody mass index, waist-to-hip ratio, and waist-to-height ratio are widely used anthropometric indices for assessing obesity-related metabolic risk; however, their relative contributions to insulin resistance remain debated and vary across different ethnicities.MethodsThis prospective cross-sectional study evaluated the correlations of body mass index, waist-to-hip ratio, and waist-to-height ratio with insulin resistance, measured by the homeostasis model assessment of insulin resistance, among 70 Syrian adult women aged 17-46 years who were consecutively recruited from the outpatient clinic in Homs governorate.ResultsScatter plots and correlation analyses were performed indicating that different anthropometric parameters are associated, to varying degrees, with the occurrence and progression of insulin resistance. Among studied anthropometric obesity indicators, body mass index has a weak, non-significant correlation with homeostasis model assessment of insulin resistance (r = 0.18, p = 0.1338), whereas waist-to-height ratio (r = 0.62, p = 0.0001) was found to be the most closely associated with occurrence of insulin resistance. Receiver operating characteristic analysis further demonstrated that waist-to-height ratio had the highest predictive accuracy for insulin resistance (area under the curve = 0.82), outperforming body mass index (area under the curve = 0.78) and waist-to-hip ratio (area under the curve = 0.74).ConclusionTherefore, waist-to-height ratio appears to be a simple and effective anthropometric tool for identifying individuals at higher risk of insulin resistance in Syrian adult women. However, as our study was only conducted on women, further investigations in men are warranted to justify its widespread adoption in clinical practice. FAU - Zam, Wissam AU - Zam W AUID- ORCID: 0000-0002-2733-1884 AD - Analytical and Food Chemistry Department, Faculty of Pharmacy, Tartous University, Syria. AD - Analytical and Food Chemistry Department, Faculty of Pharmacy, Al-Wadi International University, Syria. FAU - Farkoh, Haya AU - Farkoh H AD - Analytical and Food Chemistry Department, Faculty of Pharmacy, Al-Wadi International University, Syria. FAU - Makhoul, Jana AU - Makhoul J AD - Analytical and Food Chemistry Department, Faculty of Pharmacy, Al-Wadi International University, Syria. FAU - Youssef, Jouel AU - Youssef J AD - Analytical and Food Chemistry Department, Faculty of Pharmacy, Al-Wadi International University, Syria. LA - eng PT - Journal Article DEP - 20260610 PL - England TA - J Int Med Res JT - The Journal of international medical research JID - 0346411 SB - IM MH - Humans MH - Female MH - *Insulin Resistance MH - *Waist-Hip Ratio MH - *Body Mass Index MH - Cross-Sectional Studies MH - Adult MH - *Waist-Height Ratio MH - Syria/epidemiology MH - Middle Aged MH - Prospective Studies MH - Adolescent MH - Young Adult MH - *Obesity/diagnosis/physiopathology MH - ROC Curve PMC - PMC13554508 OTO - NOTNLM OT - Body mass index OT - Syrian adult women OT - homeostasis model assessment of insulin resistance OT - waist-to-height ratio OT - waist-to-hip ratio COIS- Declaration of conflicting interestsThe authors declare no potential conflicts of interest. EDAT- 2026/06/11 05:42 MHDA- 2026/06/12 18:41 PMCR- 2026/06/10 CRDT- 2026/06/10 22:52 PHST- 2026/06/12 18:41 [medline] PHST- 2026/06/11 05:42 [pubmed] PHST- 2026/06/10 22:52 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.1177_03000605261455139 [pii] AID - 10.1177/03000605261455139 [doi] PST - ppublish SO - J Int Med Res. 2026 Jun;54(6):3000605261455139. doi: 10.1177/03000605261455139. Epub 2026 Jun 10. PMID- 42270539 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260624 IS - 2341-2879 (Electronic) IS - 2341-2879 (Linking) VI - 104 IP - 6 DP - 2026 Jun TI - Neck circumference in screening for elevated blood pressure. PG - 504226 LID - S2341-2879(26)00183-3 [pii] LID - 10.1016/j.anpede.2026.504226 [doi] AB - INTRODUCTION: Elevated blood pressure (EBP) in childhood is associated with excess adiposity. The aim was to compare anthropometric and body composition indicators to identify EBP (>/=90th percentile) in schoolchildren. MATERIALS AND METHODS: Cross-sectional study in 497 rural Andalusian schoolchildren (6-15 years). Weight, height, circumferences (waist and neck) and skinfolds (bicipital, tricipital, subscapular, and suprailiac) were recorded to calculate body mass index, waist-to-height ratio, the sum of 4 skinfolds and body fat percentage. Blood pressure was measured by oscillometry (3 readings; mean of the last 2) and classified using Spanish age- and sex-specific references (>/=90th percentile for systolic and/or diastolic blood pressure). Age- and sex-adjusted logistic models and sex-stratified analyses of discrimination and calibration were performed; optimal cut-offs were derived using the Youden index. RESULTS: The prevalence of EBP was 5.8% and increased with excess weight, particularly in girls. After multivariable adjustment, neck circumference (NC) was the indicator most consistently associated with EBP. Discriminative ability was moderate in boys and high in girls, with optimal cut-offs of 29.15 cm and 30.65 cm, respectively. CONCLUSIONS: NC is a simple, low-cost measure that may complement traditional indicators for EBP screening in school settings and primary care; the proposed cut-offs require external validation. CI - Copyright (c) 2026 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Recio Anon, Carlos AU - Recio Anon C AD - Dispositivo de Cuidados Criticos y Urgencias, Distrito Sanitario Cordoba Guadalquivir, Cordoba, Spain; Grupo de Investigacion EPINUT Ref. 929325, Universidad Complutense de Madrid, Madrid, Spain. Electronic address: crecio02@ucm.es. FAU - Sastre Dominguez, Manuel Alejandro AU - Sastre Dominguez MA AD - Servicio de Pediatria, Hospital Universitario Reina Sofia de Cordoba, Cordoba, Spain. FAU - Carracedo Anon, Julia AU - Carracedo Anon J AD - Departamento de Genetica, Fisiologia y Microbiologia, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, Instituto de Investigacion Sanitaria Hospital 12 de Octubre (IMAS12), Madrid, Spain. FAU - Gonzalez Martin, Antonio AU - Gonzalez Martin A AD - Departamento de Biodiversidad, Ecologia y Evolucion, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, Madrid, Spain. FAU - Marrodan Serrano, Maria Dolores AU - Marrodan Serrano MD AD - Grupo de Investigacion EPINUT Ref. 929325, Universidad Complutense de Madrid, Madrid, Spain; Departamento de Biodiversidad, Ecologia y Evolucion, Facultad de Ciencias Biologicas, Universidad Complutense de Madrid, Madrid, Spain. LA - eng PT - Journal Article DEP - 20260610 PL - Spain TA - An Pediatr (Engl Ed) JT - Anales de pediatria JID - 101765626 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - *Neck/anatomy & histology MH - Female MH - Child MH - *Hypertension/diagnosis/epidemiology MH - Adolescent MH - Mass Screening/methods OTO - NOTNLM OT - Anthropometry OT - Antropometria OT - Blood pressure OT - Cuello OT - Neck OT - Obesidad infantil OT - Pediatric obesity OT - Pediatrics OT - Pediatria OT - Presion arterial COIS- Declaration of competing interest The authors have no conflicts of interest to declare. EDAT- 2026/06/11 05:42 MHDA- 2026/06/25 00:33 CRDT- 2026/06/10 22:51 PHST- 2026/02/04 00:00 [received] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/06/25 00:33 [medline] PHST- 2026/06/11 05:42 [pubmed] PHST- 2026/06/10 22:51 [entrez] AID - S2341-2879(26)00183-3 [pii] AID - 10.1016/j.anpede.2026.504226 [doi] PST - ppublish SO - An Pediatr (Engl Ed). 2026 Jun;104(6):504226. doi: 10.1016/j.anpede.2026.504226. Epub 2026 Jun 10. PMID- 42269963 OWN - NLM STAT- MEDLINE DCOM- 20260724 LR - 20260821 IS - 1878-1780 (Electronic) IS - 1262-3636 (Linking) VI - 52 IP - 4 DP - 2026 Jul TI - Persistent burden and management gaps of hypoglycemia in pediatric type 1 diabetes: insights from the Epi-GLUREDIA Study. PG - 101774 LID - S1262-3636(26)00053-4 [pii] LID - 10.1016/j.diabet.2026.101774 [doi] AB - BACKGROUND/OBJECTIVES: - Despite advances in automated insulin delivery, hypoglycemia remains a major challenge in pediatric type 1 diabetes. We aimed to characterize, in real-world practice, the burden, awareness, and daily-life impact of hypoglycemia and severe hypoglycemia (SH), and to identify gaps in perception and management. METHODS: - We conducted a prospective, descriptive, multicenter study using the new GLUREDIA questionnaire, administered during routine pediatric diabetes visits across six centers in Belgium and Luxembourg. This structured, study-specific, semi-quantitative tool assessed hypoglycemia frequency, symptom severity, perceived glycemic thresholds, SH history and management, and post-SH behavioral adaptations. Hypoglycemia awareness was evaluated using items aligned with Clarke score domains. RESULTS: - Among 232 participants, 55.9% reported hypoglycemia at least weekly, with moderate-to-high symptom severity. Cognitive and daily-life symptoms (impaired focus, fatigue, hunger, tremor) were reported by >60% and interfered with activities. Hypoglycemia was identified as the dominant disease burden by 39.7% of participants. Hypoglycemia-related symptom burden remained substantial and was not fully explained by CGM-derived metrics. SH was reported by 45.7%, without clear cause in 29.1%. Recommended management, including glucagon use, was inconsistently applied, even in recurrent SH. Following SH, participants reported insulin dose reductions (27.4%), increased sugar intake (21.1%), and avoidance of physical activities (22.1%), as adaptations. The Epi-GLUREDIA questionnaire demonstrated promising discriminative ability against the Clarke score (AUC = 0.84), supporting its construct validity. CONCLUSIONS: - Despite advances in diabetes technology, hypoglycemia remains highly prevalent, impactful, and often poorly anticipated in pediatric type 1 diabetes. Gaps in SH management and hypoglycemia awareness, together with post-event adaptations, highlight the need for integrated strategies combining education, behavioral support, optimized use of technologies, and improved implementation of guidelines, including appropriate glucagon use, to improve hypoglycemia safety, recognition, and long-term outcomes in pediatric type 1 diabetes. SUMMARY: Hypoglycemia remains frequent and impactful in pediatric type 1 diabetes, with variable symptom thresholds, unexplained severe hypoglycemia, management gaps, and post-event adaptations that may impair glycemic control. CI - Copyright (c) 2026 The Authors. Published by Elsevier Masson SAS.. All rights reserved. FAU - Beckers, Maude AU - Beckers M AD - Specialized Pediatrics Service, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium; UCLouvain, Institut de Recherche Experimentale et Clinique, EDIN laboratory, Avenue Hippocrate 55, 1200 Brussels, Belgium. FAU - Harvengt, Antoine AU - Harvengt A AD - Specialized Pediatrics Service, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium; UCLouvain, Institut de Recherche Experimentale et Clinique, EDIN laboratory, Avenue Hippocrate 55, 1200 Brussels, Belgium. FAU - Schoenmaeckers, Gaetan de Valensart AU - Schoenmaeckers GV AD - Specialized Pediatrics Service, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium. FAU - Beckers, Dominique AU - Beckers D AD - Pediatric Endocrinology and Diabetology, CHU UCL Namur, Rue Dr Gaston Therasse 1, 5530 Yvoir. FAU - Boutsen, Laure AU - Boutsen L AD - Pediatric Endocrinology and Diabetology, CHU UCL Namur, Rue Dr Gaston Therasse 1, 5530 Yvoir; UCLouvain, Institut de Recherche Experimentale et Clinique, EDIN laboratory, Avenue Hippocrate 55, 1200 Brussels, Belgium. FAU - Mouraux, Thierry AU - Mouraux T AD - Pediatric Endocrinology and Diabetology, CHU UCL Namur, Rue Dr Gaston Therasse 1, 5530 Yvoir. FAU - Gies, Inge AU - Gies I AD - Pediatric Department, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium; Vitality Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels. FAU - Staels, Willem AU - Staels W AD - Pediatric Department, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium; Beta Cell Neogenesis (BENE) research group, Genetics Reproduction and Development (GRAD), Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels. FAU - Vanbesien, Jesse AU - Vanbesien J AD - Pediatric Department, Universitair Ziekenhuis Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium; Vitality Research Group, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090 Brussels. FAU - Lysy, Philippe A AU - Lysy PA AD - Specialized Pediatrics Service, Cliniques universitaires Saint-Luc, Avenue Hippocrate 10, 1200 Brussels, Belgium; UCLouvain, Institut de Recherche Experimentale et Clinique, EDIN laboratory, Avenue Hippocrate 55, 1200 Brussels, Belgium. Electronic address: philippe.lysy@uclouvain.be. LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260610 PL - France TA - Diabetes Metab JT - Diabetes & metabolism JID - 9607599 RN - 0 (Hypoglycemic Agents) RN - 0 (Insulin) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Cost of Illness MH - *Diabetes Mellitus, Type 1/drug therapy/complications/blood MH - *Hypoglycemia/epidemiology/chemically induced/therapy MH - *Hypoglycemic Agents/adverse effects/therapeutic use/administration & dosage MH - Insulin/adverse effects/administration & dosage/therapeutic use MH - Prospective Studies MH - Surveys and Questionnaires OTO - NOTNLM OT - Adolescents/Children OT - Glucagon OT - Hypoglycemia OT - Hypoglycemia Awareness OT - Pediatric Diabetes OT - Severe Hypoglycemia OT - Type 1 Diabetes COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Philippe A. Lysy reports financial support was provided by The Leona M and Harry B Helmsley Charitable Trust. Maude Beckers reports financial support was provided by Fund for Scientific Research. Philippe A. Lysy reports financial support was provided by Saint-Luc Foundation. Willem Staels reports a relationship with Research Foundation Flanders that includes: funding grants. Willem Staels reports a relationship with Breakthrough T1D that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/11 05:41 MHDA- 2026/07/25 00:35 CRDT- 2026/06/10 19:58 PHST- 2026/04/02 00:00 [received] PHST- 2026/05/29 00:00 [revised] PHST- 2026/06/08 00:00 [accepted] PHST- 2026/07/25 00:35 [medline] PHST- 2026/06/11 05:41 [pubmed] PHST- 2026/06/10 19:58 [entrez] AID - S1262-3636(26)00053-4 [pii] AID - 10.1016/j.diabet.2026.101774 [doi] PST - ppublish SO - Diabetes Metab. 2026 Jul;52(4):101774. doi: 10.1016/j.diabet.2026.101774. Epub 2026 Jun 10. PMID- 42269926 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260702 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 74 DP - 2026 Aug TI - Age-dependent diagnostic performance of mid-upper arm circumference Z-score in pediatric neurology: A multicenter study with a cerebral palsy subgroup. PG - 103388 LID - S2405-4577(26)00485-7 [pii] LID - 10.1016/j.clnesp.2026.103388 [doi] AB - BACKGROUND: Malnutrition is a common but frequently underrecognized comorbidity in children with neurological disorders. Accurate nutritional assessment is often challenging in pediatric neurology practice due to motor impairment, skeletal deformities, and unreliable height and weight measurements. Mid-upper arm circumference Z-score (MUAC-Z) has emerged as a practical anthropometric alternative; however, its age-dependent diagnostic performance in neurologically affected children remains insufficiently defined. OBJECTIVE: To evaluate the age-specific diagnostic accuracy of MUAC-Z for detecting malnutrition in a large pediatric neurology outpatient cohort and in a predefined subgroup of children with cerebral palsy (CP). METHODS: This multicenter, analytical cross-sectional study included 3668 children aged 6 months to 19 years attending pediatric neurology outpatient clinics, including 242 children with CP. Participants were stratified into two age groups (6-60 months and 5-19 years). Malnutrition was defined as weight-for-age Z-score (WAZ) < -2 in children under 5 years and body mass index-for-age Z-score (BMI-Z) < -2 in older children. Anthropometric measurements, laboratory parameters, and enteral feeding status were recorded. Diagnostic performance of MUAC-Z was assessed using receiver operating characteristic (ROC) curve analysis. RESULTS: MUAC-Z demonstrated moderate diagnostic accuracy in children aged 6-60 months (AUC 0.772), with marked variability across early childhood subgroups. In contrast, MUAC-Z showed excellent diagnostic performance in children aged 5-19 years (AUC 0.907). In the CP subgroup, malnutrition prevalence was substantially higher across all indices. MUAC-Z showed limited accuracy in CP children under 5 years (AUC 0.668) but good diagnostic performance in those aged 5-19 years (AUC 0.774). Older malnourished children, particularly those with CP, exhibited more frequent laboratory abnormalities consistent with chronic nutritional impairment. CONCLUSIONS: The diagnostic utility of MUAC-Z in pediatric neurology is strongly age-dependent. MUAC-Z represents a reliable and practical screening tool in school-aged children and adolescents, including those with cerebral palsy, while its use in early childhood should be complementary to conventional anthropometric indices. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Dilber, Beril AU - Dilber B AD - Department of Pediatric Neurology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkiye. Electronic address: berildilber@ktu.edu.tr. FAU - Kucukali̇oglu, Burcu Pariltan AU - Kucukali̇oglu BP AD - Department of Pediatric Neurology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkiye. Electronic address: bpariltankucukalioglu@gmail.com. FAU - Emral, Hasan AU - Emral H AD - Department of Pediatric Neurology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkiye. Electronic address: hasanemral.md@gmail.com. FAU - Cansu, Ali AU - Cansu A AD - Department of Pediatric Neurology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkiye. Electronic address: acansu2011@hotmail.com. FAU - Sahin, Sevim AU - Sahin S AD - Department of Pediatric Neurology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkiye. Electronic address: sevimsahin1@yahoo.com. FAU - Tekin, Emine AU - Tekin E AD - Department of Pediatric Neurology, Faculty of Medicine, Giresun University, Giresun, Turkiye. Electronic address: dreminetekin@yahoo.com. FAU - Di̇ler Durgut, Betul AU - Di̇ler Durgut B AD - Department of Pediatric Neurology, Faculty of Medicine, Giresun University, Giresun, Turkiye. Electronic address: betuldlr@hotmail.com. FAU - Ozkan Kart, Pinar AU - Ozkan Kart P AD - Department of Pediatric Neurology, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkiye. Electronic address: drpinar_ozkan@yahoo.com. FAU - Hanci, Fatma AU - Hanci F AD - Department of Pediatric Neurology, Faculty of Medicine, Trabzon University, Trabzon, Turkiye. Electronic address: fatmah.arslan@gmail.com. FAU - Esenulku, Gulnur AU - Esenulku G AD - Department of Pediatric Neurology, Trabzon Kanuni Training and Research Hospital, Trabzon, Turkiye. Electronic address: drgesenulku@gmail.com. FAU - Bulut, Tuba AU - Bulut T AD - Department of Pediatric Neurology, Hatay Training and Research Hospital, Hatay, Turkiye. Electronic address: tubaa_bulut@hotmail.com. FAU - Ozpinar, Esra AU - Ozpinar E AD - Department of Pediatric Neurology, Faculty of Medicine, Hatay Mustafa Kemal University Hospital, Hatay, Turkiye. Electronic address: dr.esraozpinar@gmail.com. FAU - Kilic, Betul AU - Kilic B AD - Department of Pediatric Neurology, Faculty of Medicine, Medipol University Hospital, Istanbul, Turkiye. FAU - Topcu, Yasemin AU - Topcu Y AD - Department of Pediatric Neurology, Faculty of Medicine, Medipol University Hospital, Istanbul, Turkiye. Electronic address: yasmintopcu35@gmail.com. FAU - Aydin, Kursad AU - Aydin K AD - Department of Pediatric Neurology, Faculty of Medicine, Medipol University Hospital, Istanbul, Turkiye. Electronic address: kursadaydin@hotmail.com. FAU - Oz Dagdelen, Zeynep AU - Oz Dagdelen Z AD - Department of Pediatric Neurology, Istanbul Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, Istanbul, Turkiye. Electronic address: zeynep._oz@hotmail.com. FAU - Akyuz Yucel, Gulcan AU - Akyuz Yucel G AD - Department of Pediatric Neurology, Istanbul Sancaktepe Sehit Prof. Dr. Ilhan Varank Training and Research Hospital, Istanbul, Turkiye. Electronic address: gulcan.akyuz@hotmail.com. FAU - Baykan, Muge AU - Baykan M AD - Department of Pediatric Neurology, Recep Tayyip Erdogan University Rize Training and Research Hospital, Rize, Turkiye. Electronic address: dr.mugebaykan@gmail.com. FAU - Cetin, Huriye AU - Cetin H AD - Department of Pediatric Neurology, Faculty of Medicine, Gazi University, Ankara, Turkiye. Electronic address: huriyeecetin@gmail.com. FAU - Tas, Elif Nalan AU - Tas EN AD - Department of Pediatric Neurology, Faculty of Medicine, Gazi University, Ankara, Turkiye. Electronic address: en_kibarkaya@icloud.com. FAU - Petek Arhan, Ebru AU - Petek Arhan E AD - Department of Pediatric Neurology, Faculty of Medicine, Gazi University, Ankara, Turkiye. Electronic address: ebruarhan@gazi.edu.tr. FAU - Demir, Ercan AU - Demir E AD - Department of Pediatric Neurology, Faculty of Medicine, Gazi University, Ankara, Turkiye. Electronic address: ercandemir@gazi.edu.tr. FAU - Tutuncu Toker, Rabia AU - Tutuncu Toker R AD - Department of Pediatric Neurology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkiye. Electronic address: rabiatoker@uludag.edu.tr. FAU - Doganc, Tugba AU - Doganc T AD - Department of Pediatric Neurology, Faculty of Medicine, Bursa Uludag University, Bursa, Turkiye. Electronic address: tugbadoganc@uludag.edu.tr. FAU - Turkmen, Dilek AU - Turkmen D AD - Department of Pediatric Neurology, Faculty of Medicine, Erciyes University Hospital, Kayseri, Turkiye. Electronic address: dilek_bldk@hotmail.com. FAU - Per, Huseyin AU - Per H AD - Department of Pediatric Neurology, Faculty of Medicine, Erciyes University Hospital, Kayseri, Turkiye. Electronic address: huseyinper@yahoo.com. FAU - Ayanoglu, Muge AU - Ayanoglu M AD - Department of Pediatric Neurology, Faculty of Medicine, Aydin Adnan Menderes University Hospital, Aydin, Turkiye. Electronic address: mugeayanoglu_05@hotmail.com. FAU - Kamasak, Tulay AU - Kamasak T AD - Department of Pediatric Neurology, Faculty of Medicine, Aydin Adnan Menderes University Hospital, Aydin, Turkiye. Electronic address: tkamasak@hotmail.com. FAU - Guven, Burcu AU - Guven B AD - Department of Pediatric Gastroenterology, Faculty of Medicine, Karadeniz Technical University, Trabzon, Turkiye. Electronic address: burcuguven55@gmail.com. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260610 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM MH - Humans MH - Child, Preschool MH - Child MH - Adolescent MH - *Cerebral Palsy/complications/diagnosis MH - Infant MH - Cross-Sectional Studies MH - Male MH - Female MH - *Arm MH - *Malnutrition/diagnosis/epidemiology MH - *Anthropometry/methods MH - Nutrition Assessment MH - Age Factors MH - Nutritional Status MH - Young Adult MH - Body Mass Index MH - ROC Curve OTO - NOTNLM OT - Anthropometry OT - Cerebral palsy OT - MUAC-Z OT - Malnutrition OT - Mid-upper arm circumference OT - Nutritional screening OT - Pediatric neurology COIS- Conflict of interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/11 05:42 MHDA- 2026/06/27 00:57 CRDT- 2026/06/10 19:58 PHST- 2026/02/24 00:00 [received] PHST- 2026/04/26 00:00 [revised] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/06/27 00:57 [medline] PHST- 2026/06/11 05:42 [pubmed] PHST- 2026/06/10 19:58 [entrez] AID - S2405-4577(26)00485-7 [pii] AID - 10.1016/j.clnesp.2026.103388 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2026 Aug;74:103388. doi: 10.1016/j.clnesp.2026.103388. Epub 2026 Jun 10. PMID- 42269380 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260722 IS - 1618-131X (Electronic) IS - 1438-4639 (Linking) VI - 276 DP - 2026 Jul TI - Uncovering hidden beta-adrenergic agonist exposure from meat consumption through nationally representative human biomonitoring in Taiwan. PG - 114849 LID - S1438-4639(26)00109-4 [pii] LID - 10.1016/j.ijheh.2026.114849 [doi] AB - BACKGROUND: Despite stringent bans on clenbuterol in livestock production, its prolonged half-life poses a potential risk for human bioaccumulation. Conversely, legally permitted additives like ractopamine undergo rapid metabolism. This study utilized human biomonitoring (HBM) to uncover hidden beta-adrenergic agonist exposures in Taiwan, contrasting internal body burdens with traditional market surveillance data. METHODS: We analyzed data from a nationally representative sample of 1554 participants in the 2019 Taiwan Human BioMonitoring Program. Spot urine samples were tested for eight beta-adrenergic agonists using ultra-trace isotope dilution online SPE-LC-MS/MS. Dietary habits, including meat and egg consumption frequencies, were assessed via validated food frequency questionnaires. Associations were evaluated using survey-weighted logistic regression models. RESULTS: Clenbuterol was the most frequently detected beta-adrenergic agonist (31.4%), starkly contrasting with its zero-detection rate in recent official market surveillance. In contrast, the legally permitted ractopamine was detected in only 4.2% of samples. After adjusting for confounders, urinary clenbuterol detection showed a significant association with red meat consumption (adjusted odds ratio = 1.39, 95% CI: 1.08-1.79, p = 0.011). CONCLUSIONS: A significant portion of the Taiwanese general population experiences hidden, low-dose exposure to clenbuterol. This prevalence highlights a critical gap between routine regulatory testing limits and the bioaccumulation potential of clenbuterol from red meat consumption. HBM proves essential for uncovering these hidden exposures. Integrating ultra-trace HBM data into public health frameworks is necessary to accurately assess dietary risks and effectively manage food safety policies. CI - Copyright (c) 2026 Elsevier GmbH. All rights reserved. FAU - Liao, Ho-Tang AU - Liao HT AD - National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan. FAU - Peng, Tzu-Hsuan AU - Peng TH AD - Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan. FAU - Wang, Chien-Jen AU - Wang CJ AD - National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan. FAU - Hsu, Jing-Fang AU - Hsu JF AD - Department of Occupational Safety and Health, Chung Shan Medical University, Taichung, Taiwan; Department of Occupational Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan. FAU - Lin, Ching-Chun AU - Lin CC AD - Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan. FAU - Pan, Wen-Harn AU - Pan WH AD - College of Public Health, Taipei Medical University, New Taipei, Taiwan. FAU - Chia, Shu-Lih AU - Chia SL AD - Ministry of Health and Welfare, Taipei, Taiwan. FAU - Chen, Pau-Chung AU - Chen PC AD - National Institute of Environmental Health Sciences, National Health Research Institutes, Miaoli, Taiwan; Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Public Health, National Taiwan University College of Public Health, Taipei, Taiwan; Department of Environmental and Occupational Medicine, National Taiwan University College of Medicine and Hospital, Taipei, Taiwan. Electronic address: pchen@ntu.edu.tw. LA - eng PT - Journal Article DEP - 20260610 PL - Germany TA - Int J Hyg Environ Health JT - International journal of hygiene and environmental health JID - 100898843 RN - 0 (Adrenergic beta-Agonists) RN - XTZ6AXU7KN (Clenbuterol) RN - 57370OZ3P1 (ractopamine) RN - 0 (Phenethylamines) SB - IM MH - Humans MH - *Adrenergic beta-Agonists/urine MH - Taiwan MH - Biological Monitoring MH - Female MH - Adult MH - Male MH - *Meat MH - Middle Aged MH - Clenbuterol/urine MH - Food Contamination/analysis MH - Young Adult MH - *Dietary Exposure/analysis MH - Aged MH - Phenethylamines/urine MH - Adolescent MH - Environmental Exposure OTO - NOTNLM OT - Dietary exposure OT - General population OT - Human biomonitoring OT - Leanness-enhancing agent OT - beta-adrenergic agonist COIS- Declaration of competing interest The authors declare no conflict of interest. EDAT- 2026/06/11 05:43 MHDA- 2026/07/23 05:36 CRDT- 2026/06/10 18:06 PHST- 2026/03/18 00:00 [received] PHST- 2026/05/30 00:00 [revised] PHST- 2026/06/09 00:00 [accepted] PHST- 2026/07/23 05:36 [medline] PHST- 2026/06/11 05:43 [pubmed] PHST- 2026/06/10 18:06 [entrez] AID - S1438-4639(26)00109-4 [pii] AID - 10.1016/j.ijheh.2026.114849 [doi] PST - ppublish SO - Int J Hyg Environ Health. 2026 Jul;276:114849. doi: 10.1016/j.ijheh.2026.114849. Epub 2026 Jun 10. PMID- 42269336 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260813 IS - 1878-9307 (Electronic) IS - 1878-9293 (Print) IS - 1878-9293 (Linking) VI - 80 DP - 2026 Aug TI - ABCD-ReproNim: An educational program for responsible and reproducible analyses of ABCD data. PG - 101755 LID - S1878-9293(26)00092-7 [pii] LID - 10.1016/j.dcn.2026.101755 [doi] LID - 101755 AB - ABCD-ReproNim is a research educational course that provides training in responsible and reproducible analyses of data from the Adolescent Brain Cognitive Development (ABCD) Study. ABCD-ReproNim was established in 2020 and structured as a collaborative partnership between ABCD investigators and ReproNim, a NIBIB-funded P41 center for reproducible neuroimaging whose vision is to help researchers achieve more reproducible data analysis workflows and outcomes. With over 1.1 K registered students and > 18 K YouTube views, ABCD-ReproNim has been well-received by the community and is providing ABCD data training while promoting skill development in reproducible analyses that support efficient, re-executable design and FAIR practices. Participants first receive didactic training across a semester-long online course that includes lectures, readings, and data exercises. We use an innovative curricular approach that is grounded in modern, transformational methods of STEM pedagogy, which includes philosophies and features drawn from active learning, inverted classrooms, and hack weeks. At the completion of the course, participants contribute to team-based, collaborative data analysis projects during an in-person hackathon at the host institution, Florida International University, in Miami, Florida. Through this research educational program, we provide (i) a comprehensive understanding of the ABCD dataset; (ii) instructional techniques that enhance the validity and reproducibility of research methods; (iii) support of interdisciplinary, team-based collaborations; and (iv) dissemination of the course, project materials, and research findings. Our overall goal is to contribute to the generation of a cadre of investigators that are well trained in the techniques that support responsible, reproducible, and valid analyses of ABCD data. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Laird, Angela R AU - Laird AR AD - Department of Physics, Florida International University, Miami, FL, USA. Electronic address: alaird@fiu.edu. FAU - Bartley, Jessica E AU - Bartley JE AD - Department of Physics, Florida International University, Miami, FL, USA. FAU - Peraza, Julio A AU - Peraza JA AD - Department of Physics, Florida International University, Miami, FL, USA. FAU - Poline, Jean-Baptiste AU - Poline JB AD - McConnell Brain Imaging Centre, The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada. FAU - Ghosh, Satrajit S AU - Ghosh SS AD - McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA, USA. FAU - Kennedy, David N AU - Kennedy DN AD - Departments of Psychiatry and Radiology, University of Massachusetts Chan Medical School, Worcester, MA, USA. LA - eng PT - Journal Article DEP - 20260605 PL - Netherlands TA - Dev Cogn Neurosci JT - Developmental cognitive neuroscience JID - 101541838 SB - IM MH - Humans MH - Reproducibility of Results MH - Adolescent MH - *Adolescent Development/physiology MH - *Neuroimaging MH - *Brain/diagnostic imaging/growth & development MH - *Cognition/physiology MH - Curriculum PMC - PMC13273906 OTO - NOTNLM OT - ABCD OT - ABCD-ReproNim OT - Hackathon OT - ReproNim OT - Research educational course COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/11 05:43 MHDA- 2026/08/11 23:35 PMCR- 2026/06/05 CRDT- 2026/06/10 18:04 PHST- 2025/12/01 00:00 [received] PHST- 2026/02/09 00:00 [revised] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/08/11 23:35 [medline] PHST- 2026/06/11 05:43 [pubmed] PHST- 2026/06/10 18:04 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - S1878-9293(26)00092-7 [pii] AID - 101755 [pii] AID - 10.1016/j.dcn.2026.101755 [doi] PST - ppublish SO - Dev Cogn Neurosci. 2026 Aug;80:101755. doi: 10.1016/j.dcn.2026.101755. Epub 2026 Jun 5. PMID- 42269021 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260923 IS - 2369-1999 (Electronic) IS - 2369-1999 (Linking) VI - 12 DP - 2026 Jun 10 TI - Monitoring Steps and Heart Rate Using a Withings Smartwatch in Children and Adolescents With Cancer: Validation Study. PG - e77766 LID - 10.2196/77766 [doi] LID - e77766 AB - BACKGROUND: Consumer smartwatches offer potential for continuous monitoring of physical activity during childhood cancer treatment. However, their validity for measuring step count and heart rate in this population has not been established. OBJECTIVE: This study examined the validity of a Withings smartwatch for monitoring step count and heart rate in children and adolescents undergoing cancer treatment. METHODS: Children and adolescents aged 8 to 18 years under active cancer treatment wore a Withings smartwatch for 12 weeks. For validation purposes, children and adolescents simultaneously wore an ActiGraph wGT3X-BT accelerometer for 1 week under free-living conditions to assess step count agreement and were connected to a clinical heart rate monitor under resting conditions to assess heart rate agreement. Linear mixed models with participant ID as a random effect were used to estimate mean differences and derive 95% limits of agreement for repeated measurements. RESULTS: A total of 14 children and adolescents participated in each of the validation analyses. The smartwatch recorded significantly fewer steps than the ActiGraph accelerometer for both steps per hour (mean difference 174 steps per hour; 95% limits of agreement=-283 to 633; P<.001) and steps per day (mean difference 3154 steps per day; 95% limits of agreement=-394 to 6702; P<.001), with increasing discrepancy at higher activity levels, suggesting proportional bias. No statistically significant difference in heart rate was observed between the smartwatch and the clinical heart rate monitor under resting conditions (mean difference -1.07 beats per minute; 95% limits of agreement=-17.55 to 15.41; P=.24). CONCLUSIONS: In children and adolescents undergoing cancer treatment, the Withings smartwatch showed minimal systematic bias for resting heart rate assessment, although individual variability was considerable. In contrast, step counts demonstrated systematic underestimation and wide limits of agreement compared with a research-grade accelerometer. The use of smartwatch-derived step counts for clinical benchmarking or goal setting in this population cannot currently be recommended. CI - (c)Emma den Hartog, Marta Fiocco, Patrick van der Torre, Wim J E Tissing, Emma J Verwaaijen. Originally published in JMIR Cancer (https://cancer.jmir.org). FAU - den Hartog, Emma AU - den Hartog E AUID- ORCID: 0009-0005-6373-2625 AD - Princess Maxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, 3584 CS, The Netherlands, 31 0889727272. FAU - Fiocco, Marta AU - Fiocco M AUID- ORCID: 0000-0001-5588-0277 AD - Princess Maxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, 3584 CS, The Netherlands, 31 0889727272. AD - Mathematical Institute, Leiden University, Leiden, The Netherlands. FAU - van der Torre, Patrick AU - van der Torre P AUID- ORCID: 0000-0001-9697-2418 AD - Princess Maxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, 3584 CS, The Netherlands, 31 0889727272. FAU - Tissing, Wim J E AU - Tissing WJE AUID- ORCID: 0000-0001-9101-507X AD - Princess Maxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, 3584 CS, The Netherlands, 31 0889727272. AD - Department of Pediatric Oncology and Hematology, University of Groningen, Beatrix Children's Hospital, Groningen, The Netherlands. FAU - Verwaaijen, Emma J AU - Verwaaijen EJ AUID- ORCID: 0000-0003-1350-3363 AD - Princess Maxima Center for Pediatric Oncology, Heidelberglaan 25, Utrecht, 3584 CS, The Netherlands, 31 0889727272. LA - eng PT - Journal Article PT - Validation Study DEP - 20260610 PL - Canada TA - JMIR Cancer JT - JMIR cancer JID - 101666844 SB - IM MH - Humans MH - Adolescent MH - Child MH - *Heart Rate/physiology MH - Female MH - Male MH - *Neoplasms/physiopathology/therapy MH - *Exercise/physiology MH - Accelerometry/instrumentation/methods MH - Reproducibility of Results PMC - PMC13252708 OTO - NOTNLM OT - heart rate OT - pediatric oncology OT - smartwatch OT - steps OT - validity COIS- Conflicts of Interest: None declared. EDAT- 2026/06/11 05:39 MHDA- 2026/06/12 13:01 PMCR- 2026/06/10 CRDT- 2026/06/10 14:43 PHST- 2025/05/19 00:00 [received] PHST- 2026/03/10 00:00 [revised] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/06/12 13:01 [medline] PHST- 2026/06/11 05:39 [pubmed] PHST- 2026/06/10 14:43 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - v12i1e77766 [pii] AID - 77766 [pii] AID - 10.2196/77766 [doi] PST - epublish SO - JMIR Cancer. 2026 Jun 10;12:e77766. doi: 10.2196/77766. PMID- 42268871 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - Geospatial variation and machine learning approaches to predict open defecation practice in Zambia. PG - e0350923 LID - 10.1371/journal.pone.0350923 [doi] LID - e0350923 AB - BACKGROUND: Open defecation is the disposal of human feces in fields, bushes, forests, open waterways, beaches, and other open areas. It worsens the environment, contaminates drinking water sources, causes malnutrition and low school attendance in children, and aids in the spread of diseases like cholera, diarrhea, dysentery, typhoid, polio, and hepatitis A. The purpose of this study was geospatial variation and machine learning approaches to predict open defecation in Zambia. METHODS: This study used secondary data analysis from the cross-sectional Zambia Demographic and Health Survey (ZMDHS) 2024. Spatial distribution, spatial autocorrelation, incremental autocorrelation, spatial interpolation, and hot spot area detection were all examined using ArcGIS 10.7. Python was used to identify the features of open defecation practice using machine-learning algorithms. We carried out an 80/20% data split, one-hot data encoding, data transformation and integration, data cleaning, and 10-fold stratified cross-validation. This study employed seven machine-learning algorithms, including adaptive boosting, cat boosting, random forest, light boosting, extreme gradient boosting, decision tree and logistic regression. RESULTS: Among 12,808 households in Zambia, 12.1% were practiced open defecation. Spatial analysis revealed significant clustering, with hot spots concentrated in Southern, Western and Eastern regions, highlighting areas in urgent need of intervention. Machine learning models were applied to predict open defecation practices, with light gradient boost performing the best model with AUC of 83.83%. From this study, 198 true positives were generated by the model for the classification of open defecation practice, accurately identifying those who reported engaging in this behavior. CONCLUSION: Wealth index, access to treated water, access to electricity, educational level, and age of household head, access to media, and region were the most significant features of open defecation practice. Governments, NGOs, policy makers, and researchers can use these data to create targeted interventions for improving health and environmental sanitation based on the gaps and disparities discovered. CI - Copyright: (c) 2026 Birlie et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Birlie, Andualem Addisu AU - Birlie AA AUID- ORCID: 0009-0000-2337-0192 AD - Department of Health Informatics, College of Medicine and Health Science, Samara University, Samara, Ethiopia. FAU - Meshesha, Nega Abebe AU - Meshesha NA AD - Department of Public Health, Institute of Health, Dambi Dollo University, Dambi Dollo, Ethiopia. FAU - Tizie, Sefefe Birhanu AU - Tizie SB AD - Department of Health Informatics, College of Medicine and Health Science, Debre Markos University, Debre Markos, Ethiopia. FAU - Wondie, Smegnew Gichew AU - Wondie SG AD - Department of Public Health, College of Medicine and Health Science, Mizan Tepi University, Mizan Aman, Ethiopia. FAU - Teshome, Selamawit Gashaw AU - Teshome SG AD - School of Public Health, Health Science Campus, Debre Berhan University, Debre Berhan, Ethiopia. FAU - Bedada, Tesfaye Deribe AU - Bedada TD AUID- ORCID: 0009-0003-7102-5790 AD - Department of Health Informatics, School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. FAU - Muluneh, Ayana Alebachew AU - Muluneh AA AD - Department of Health Informatics, College of Medicine and Health Science, Wollo University, Dessie, Ethiopia. FAU - Eticha, Biruktawit Lelisa AU - Eticha BL AD - Department of Health Informatics, School of Public Health, College of Medicine and Health Science, Wachemo University, Hossana, Ethiopia. FAU - Dube, Geleta Nenko AU - Dube GN AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. FAU - Wodessa, Gelgelo AU - Wodessa G AD - School of Public Health, Institute of Health, Bule Hora University, Bule Hora, Ethiopia. FAU - Mengistie, Muluken Belachew AU - Mengistie MB AUID- ORCID: 0000-0002-0606-9477 AD - Department of Health Informatics, College of Medicine and Health Science, Debre Markos University, Debre Markos, Ethiopia. LA - eng PT - Journal Article DEP - 20260610 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Zambia MH - Humans MH - *Machine Learning MH - Boosting Machine Learning Algorithms MH - Random Forest MH - *Defecation MH - Predictive Learning Models MH - Cross-Sectional Studies MH - Classification Algorithms MH - Prediction Algorithms MH - Spatial Analysis PMC - PMC13252813 COIS- The authors declare that there are no competing interests. EDAT- 2026/06/11 05:39 MHDA- 2026/06/15 11:31 PMCR- 2026/06/10 CRDT- 2026/06/10 13:43 PHST- 2026/03/05 00:00 [received] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/15 11:31 [medline] PHST- 2026/06/11 05:39 [pubmed] PHST- 2026/06/10 13:43 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - PONE-D-26-11222 [pii] AID - 10.1371/journal.pone.0350923 [doi] PST - epublish SO - PLoS One. 2026 Jun 10;21(6):e0350923. doi: 10.1371/journal.pone.0350923. eCollection 2026. PMID- 42268692 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260624 IS - 1938-2359 (Electronic) IS - 0090-4481 (Linking) VI - 55 IP - 6 DP - 2026 Jun TI - Risks and Benefits of Social Media on Adolescent Health. PG - e222-e228 LID - 10.3928/19382359-20260223-02 [doi] AB - Adolescents increasingly construct aspects of their identity and form relationships by interacting on social media; yet, clinical frameworks lag behind technological change. This review synthesizes recent evidence on how platform design, usage patterns, and individual differences influence both benefits and harms. Problematic use is associated with sleep disturbance, mood and attention disorders, body image concerns, cyberbul-lying, and exposure to self-harm content, with disproportionate burdens for female patients and youth who are marginalized. Meanwhile, online communities can foster connection, coping, and help seeking, particularly for adolescents facing stigma or isolation. We propose a structured, developmentally informed workflow incorporating brief screening, targeted use of validated tools, and collaborative family media planning. Rather than centering total screen time, we emphasize function-focused, harm-reduction approaches to harness digital platforms as a tool for adolescent health. FAU - Sellars, Suzanna E AU - Sellars SE AD - Department of Pediatrics, Craig Dalsimer Division of Adolescent Medicine, Children's Hospital of Philadelphia, Pennsylvania. FAU - Kabra, Rashi AU - Kabra R AD - Department of Pediatrics, Craig Dalsimer Division of Adolescent Medicine, Children's Hospital of Philadelphia, Pennsylvania. LA - eng PT - Journal Article PT - Review DEP - 20260601 PL - United States TA - Pediatr Ann JT - Pediatric annals JID - 0356657 SB - IM MH - Adolescent MH - Humans MH - *Adolescent Behavior/psychology MH - *Adolescent Health MH - *Digital Media MH - *Media Exposure MH - *Social Media COIS- Disclosure: SES has received support for attending meetings and travel from Children's Hospital of Philadelphia (CHOP) GME (Graduate Medical Education) and Leadership and Education in Adolescent Health Program at CHOP. RK has received support for attending meetings and travel from CHOP. EDAT- 2026/06/11 05:39 MHDA- 2026/06/13 00:40 CRDT- 2026/06/10 12:04 PHST- 2026/06/13 00:40 [medline] PHST- 2026/06/11 05:39 [pubmed] PHST- 2026/06/10 12:04 [entrez] AID - 10.3928/19382359-20260223-02 [doi] PST - ppublish SO - Pediatr Ann. 2026 Jun;55(6):e222-e228. doi: 10.3928/19382359-20260223-02. Epub 2026 Jun 1. PMID- 42268165 OWN - NLM STAT- MEDLINE DCOM- 20261005 LR - 20261005 IS - 1878-2620 (Electronic) IS - 1499-4046 (Linking) VI - 58 IP - 10 DP - 2026 Oct TI - Development and Application of the Paced Bottle-Feeding Checklist. PG - 997-1004 LID - S1499-4046(26)00105-3 [pii] LID - 10.1016/j.jneb.2026.04.012 [doi] AB - OBJECTIVE: Characterize the paced bottle-feeding (PBF) Checklist, evaluate its preliminary reliability and validity, and examine associations between PBF adherence, feeding practices, and sociodemographic characteristics. METHODS: Interrater reliability of the coding scheme was assessed using intraclass correlations from a secondary analysis of data from a within-subject experimental study of mother-infant feeding interactions. General linear models determined associations between PBF and key variables. RESULTS: Coders achieved good interrater reliability (intraclass correlation = 0.81). Paced bottle-feeding scores significantly higher during the PBF condition than in the typical bottle-feeding condition (P = 0.01). Scores associated with family income (P = 0.009) and federal assistance program participation (P < 0.001), with higher scores for mothers with higher income and those not participating in federal assistance programs. CONCLUSIONS AND IMPLICATIONS: The checklist is a practical tool for clinical use, enabling tailored education for bottle-feeding families. Future research can explore its impact on infant growth trajectories and expand its use to other caregivers. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Richardson, Taylor N AU - Richardson TN AD - College of Nursing, East Carolina University, Greenville, NC. Electronic address: nelsonta22@ecu.edu. FAU - Kay, Melissa C AU - Kay MC AD - Department of Pediatrics and Epidemiology and Prevention, School of Medicine, Wake Forest University, Winston-Salem, NC. FAU - Ventura, Alison K AU - Ventura AK AD - Department of Kinesiology and Public Health and Center for Health Research, California Polytechnic State University, San Luis Obispo, CA. LA - eng PT - Journal Article DEP - 20260610 PL - United States TA - J Nutr Educ Behav JT - Journal of nutrition education and behavior JID - 101132622 SB - IM MH - Humans MH - *Bottle Feeding/methods/statistics & numerical data MH - *Checklist/methods MH - Infant MH - Female MH - Reproducibility of Results MH - Mother-Child Relations MH - Adult MH - Mothers OTO - NOTNLM OT - bottle feeding OT - feeding behavior OT - infant food OT - parent-child relations COIS- Conflict of Interest Disclosure The authors have not stated any conflicts of interest. EDAT- 2026/06/10 11:43 MHDA- 2026/10/05 23:29 CRDT- 2026/06/10 10:29 PHST- 2025/01/17 00:00 [received] PHST- 2026/04/17 00:00 [revised] PHST- 2026/04/19 00:00 [accepted] PHST- 2026/10/05 23:29 [medline] PHST- 2026/06/10 11:43 [pubmed] PHST- 2026/06/10 10:29 [entrez] AID - S1499-4046(26)00105-3 [pii] AID - 10.1016/j.jneb.2026.04.012 [doi] PST - ppublish SO - J Nutr Educ Behav. 2026 Oct;58(10):997-1004. doi: 10.1016/j.jneb.2026.04.012. Epub 2026 Jun 10. PMID- 42267872 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2639-8028 (Electronic) IS - 2639-8028 (Linking) VI - 8 IP - 6 DP - 2026 Jun 1 TI - Divergence Between Net Fluid and Weight-Based Evaluation in Calculating Cumulative Fluid Balance. PG - e1411 LID - 10.1097/CCE.0000000000001411 [doi] LID - e1411 AB - OBJECTIVE: Although efforts have been made to standardize fluid balance calculations in the ICU, there is a limited understanding of how different calculation methods relate to one another across an ICU admission. We quantified the agreement between the cumulative fluid balance calculated from fluid intake and output (CFBf) and cumulative fluid balance calculated from serial weights (CFBw) in critically ill children during the first week of ICU admission. DESIGN: Retrospective, multicenter, federated observational study. SETTING: Four pediatric medical-SICUs (PICU) and two pediatric cardiac ICUs (PCICU) from four tertiary care centers. PATIENTS: Analysis included 8,895 pediatric patients (younger than 19 yr) representing 12,388 ICU encounters from 2023 to 2024. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: A patient's anchor weight was the weight closest to ICU admission. CFBf and CFBw were calculated at the time of new weight measurements. We assessed agreement between CFBf and CFBw using Bland-Altman analyses, stratified by ICU day and patient subgroups (neonates, early anchor weights [weight on ICU day 0], and encounters with unmeasured urine occurrences). Across all units and subgroups, CFBf exceeded CFBw (mean difference: all patients = 4.7 %CFB, early anchor weight = 4.7 %CFB, neonates = 5.9 %CFB). The mean difference increased significantly over time (days 0-3: 2.7% vs. days 4-7: 8.1%, p < 0.05), with greater divergence in neonates and those with early anchor weights. CONCLUSIONS: CFBf consistently exceeded CFBw across all subgroups, with a greater divergence on ICU days 4-7. Clinicians should understand these differences, prioritizing early and frequent patient weights throughout ICU admission. Future studies should assess each method's association with patient outcomes to identify the most clinically informative CFB method. CI - Copyright (c) 2026 The Authors. Published by Wolters Kluwer Health, Inc. on behalf of the Society of Critical Care Medicine. FAU - Shinnick, Finley J AU - Shinnick FJ AD - Department of Pediatrics, Golisano Children's Hospital, University of Rochester School of Medicine, Rochester, NY. FAU - Hasson, Denise C AU - Hasson DC AD - Department of Pediatrics, Hassenfeld Children's Hospital at NYU Langone Health, New York, NY. FAU - Kothari, Ulka AU - Kothari U AD - Department of Pediatrics, NYU Long Island School of Medicine, Mineola, NY. FAU - Shah, Ami AU - Shah A AD - Department of Pediatrics, Hassenfeld Children's Hospital at NYU Langone Health, New York, NY. FAU - Odum, James D AU - Odum JD AD - Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL. FAU - Braun, Chloe G AU - Braun CG AD - Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY. FAU - Dixon, Celeste G AU - Dixon CG AD - Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. FAU - Fitzgerald, Julie C AU - Fitzgerald JC AD - Department of Anesthesiology and Critical Care Medicine, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA. FAU - Martin, Susan D AU - Martin SD AD - Department of Pediatrics, Golisano Children's Hospital, University of Rochester School of Medicine, Rochester, NY. FAU - Terry, Nina AU - Terry N AD - Department of Pediatrics, Golisano Children's Hospital, University of Rochester School of Medicine, Rochester, NY. FAU - Dziorny, Adam C AU - Dziorny AC AUID- ORCID: 0000-0002-3392-2795 AD - Department of Pediatrics, Golisano Children's Hospital, University of Rochester School of Medicine, Rochester, NY. CN - Evidence-Driven Evaluation and Management of fluid Accumulation (EDEMA) Collaborative LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260610 PL - United States TA - Crit Care Explor JT - Critical care explorations JID - 101746347 SB - IM UOF - medRxiv. 2025 Nov 04:2025.10.22.25338544. doi: 10.1101/2025.10.22.25338544. PMID: 41282779 MH - Humans MH - *Water-Electrolyte Balance/physiology MH - Retrospective Studies MH - Critical Illness/therapy MH - Infant MH - Intensive Care Units, Pediatric MH - Male MH - Female MH - Child MH - *Body Weight/physiology MH - Child, Preschool MH - Infant, Newborn PMC - PMC13252996 OTO - NOTNLM OT - cumulative fluid balance OT - fluid balance assessment OT - fluid overload OT - pediatric intensive care unit COIS- The authors have disclosed that they do not have any potential conflicts of interest. FIR - Barbera, Andrew IR - Barbera A IRAD- (University of Alabama Birmingham, Birmingham, AL). FIR - Clifford, Rebecca IR - Clifford R IRAD- (Nemours Children's Health, Wilmington, DE). FIR - Dapul, Heda M IR - Dapul HM IRAD- (NYU Langone Health, New York, NY). FIR - Fitts, Brittany IR - Fitts B IRAD- (Nemours Children's Health, Wilmington, DE). FIR - Gettelfinger, Jacquelyn IR - Gettelfinger J IRAD- (Norton Healthcare, Louisville, KY). FIR - Grey, Erin IR - Grey E IRAD- (Nemours Children's Health, Wilmington, DE). FIR - Hopwood, Andrew IR - Hopwood A IRAD- (UNC School of Medicine, Chapel Hill, NC). FIR - Kavanaugh, Taylor IR - Kavanaugh T IRAD- (University of Louisville, Louisville, KY). FIR - Lapira, Jenna IR - Lapira J IRAD- (Nemours Children's Health, Wilmington, DE). FIR - Levenbrown, Yosef IR - Levenbrown Y IRAD- (Nemours Children's Health, Wilmington, DE). FIR - Martinez, Michael IR - Martinez M IRAD- (NYU Langone Health, New York, NY). FIR - Weiss, Scott IR - Weiss S IRAD- (Nemours Children's Health, Wilmington, DE). FIR - Weyback, Caroline IR - Weyback C IRAD- (NYU Langone Health, New York, NY). FIR - Williams, Allison IR - Williams A IRAD- (University of Alabama Birmingham, Birmingham, AL). EDAT- 2026/06/10 11:44 MHDA- 2026/06/13 00:38 PMCR- 2026/06/10 CRDT- 2026/06/10 09:33 PHST- 2026/06/13 00:38 [medline] PHST- 2026/06/10 11:44 [pubmed] PHST- 2026/06/10 09:33 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 02107256-202606000-00015 [pii] AID - CCE-D-26-00047 [pii] AID - 10.1097/CCE.0000000000001411 [doi] PST - epublish SO - Crit Care Explor. 2026 Jun 10;8(6):e1411. doi: 10.1097/CCE.0000000000001411. eCollection 2026 Jun 1. PMID- 42267217 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260610 LR - 20260813 IS - 2071-9736 (Electronic) IS - 1025-9848 (Print) IS - 1025-9848 (Linking) VI - 31 DP - 2026 TI - Prevalence of overweight, obesity and central adiposity among grade seven adolescents in urban Tshwane, South Africa. PG - 3328 LID - 10.4102/hsag.v31i0.3328 [doi] LID - 3328 AB - BACKGROUND: The global increase in overweight and obesity among adolescents is a significant public health priority, especially in low- and middle-income countries. In South Africa, urbanisation and lifestyle changes have exacerbated this challenge, but there is a lack of disaggregated data available to inform effective local responses. AIM: To assess and describe the prevalence of overweight, obesity and central adiposity in Grade seven adolescents in urban Tshwane, South Africa, and explore its association with socioeconomic characteristics. SETTING: The study was conducted in five diverse fee-paying public primary schools in urban Tshwane, Gauteng province. METHODS: A quantitative, descriptive cross-sectional design recruited 164 adolescents aged 11-14 years. Anthropometric measures were performed according to World Health Organization (WHO) standards. These included a survey of height and weight to derive body mass index (BMI-for-age) z-scores, as well as waist circumference to height ratio (WHtR). Socioeconomic status was assessed using the validated Family Affluence Scale. Data analysis included descriptive statistics and chi-square tests to determine the association between categorical variables. RESULTS: The combined prevalence of overweight and obesity was 23.7%, with a greater burden among girls (36.4% of 12 year olds) compared to boys (16.7%). The risk of central adiposity (WHtR >/= 0.5) was found in 25% of participants, with 7.3% at very high risk. Household income was significantly associated with obesity (p = 0.043), while parental education was not statistically significant. CONCLUSION: The high prevalence of excess adiposity, particularly among female adolescents, indicates an emerging cardiometabolic risk profile among the group. CONTRIBUTION: This study addresses a critical gap in South African public health literature by providing locally specific, disaggregated data on the nutritional status of urban adolescents in Tshwane, a cohort that is underrepresented in contrast to conventional rural or national surveys. CI - (c) 2026. The Authors. FAU - Mokose, Nonie M AU - Mokose NM AUID- ORCID: 0009-0009-8300-0869 AD - Department of Sustainable Food Systems and Development, Faculty of Natural and Agricultural Sciences, University of the Free State, Bloemfontein, South Africa. FAU - Swanepoel, Jan W AU - Swanepoel JW AUID- ORCID: 0000-0002-0812-2657 AD - Department of Sustainable Food Systems and Development, Faculty of Natural and Agricultural Sciences, University of the Free State, Bloemfontein, South Africa. FAU - Oldewage-Theron, Wilna AU - Oldewage-Theron W AUID- ORCID: 0000-0001-8975-5693 AD - Department of Sustainable Food Systems and Development, Faculty of Natural and Agricultural Sciences, University of the Free State, Bloemfontein, South Africa. LA - eng PT - Journal Article DEP - 20260526 PL - South Africa TA - Health SA JT - Health SA = SA Gesondheid JID - 101213385 PMC - PMC13243840 OTO - NOTNLM OT - South Africa OT - Urban health OT - adolescent obesity OT - central adiposity OT - overweight OT - socioeconomic status COIS- The authors declare that they have no financial or personal relationships that may have inappropriately influenced them in writing this article. EDAT- 2026/06/10 06:52 MHDA- 2026/06/10 06:53 PMCR- 2026/05/26 CRDT- 2026/06/10 04:45 PHST- 2025/11/11 00:00 [received] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/06/10 06:53 [medline] PHST- 2026/06/10 06:52 [pubmed] PHST- 2026/06/10 04:45 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - HSAG-31-3328 [pii] AID - 10.4102/hsag.v31i0.3328 [doi] PST - epublish SO - Health SA. 2026 May 26;31:3328. doi: 10.4102/hsag.v31i0.3328. eCollection 2026. PMID- 42266680 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Immunogenetic HLA-DQ and IgG serological profiles in individuals with self-reported wheat/gluten sensitivity: a retrospective real-world evidence study. PG - 1814097 LID - 10.3389/fimmu.2026.1814097 [doi] LID - 1814097 AB - INTRODUCTION: Many patients report adverse symptoms following wheat/gluten consumption. As "Self-Reported Wheat/Gluten Sensitivity" lacks gold-standard biomarkers, characterizing biological profiles in Western populations is essential for precision management. This study analyzes immunogenetic (HLA-DQ) and serological (IgG) patterns in a real-world clinical cohort. METHODS: A retrospective observational study used Real-World Evidence (RWE) from 100 symptomatic individuals (2019-2024) selected via non-probabilistic convenience sampling. Participants underwent HLA-DQ genotyping and serum IgG reactivity testing for wheat/gluten via a validated ELISA-based assay. Data normality was formally assessed using the Shapiro-Wilk test, revealing a non-parametric distribution (W=0.59, p<0.001). Consequently, inferential analyses included Chi-square (X (2)) tests for categorical associations, Spearman's rank correlation (r(s) ), and Odds Ratio (OR) calculations with 95% Confidence Intervals (95% CI). RESULTS: A 100% cumulative frequency of HLA-DQ susceptibility variants was observed. The immunogenetic landscape revealed complex heterozygosity: DQ1 was most prevalent (56%), followed by DQ2 (54%), DQ3 (40%), and DQ8 (33%). DQ8 (X(2) = 10.24; p=0.001) and DQ3 (X(2) = 4.84; p=0.028) were significant markers. Specific IgG reactivity occurred in 68% of cases, showing strong wheat-gluten correlation (r(s)=0.887; p<0.001) and extraordinary cross-reactivity (OR=88.2; 95% CI: 25.8-301.4; p<0.001). DISCUSSION: Findings reveal a ubiquitous HLA-DQ frequency, suggesting a consistent genetic background in symptomatic individuals that significantly exceeds prevalence in the general Western population. This enriched 'mosaic' may facilitate immune activation. Furthermore, the observed IgG cross-reactivity validates the 'wheat/gluten complex' as a synchronized immunological unit, supporting a transition toward biomarker-informed nutrition in real-world settings. CI - Copyright (c) 2026 White, Verzura, White, Rodriguez, White and Garcia Bravo. FAU - White, Andreina AU - White A AD - Universidad Central de Venezuela (UCV), Caracas, Venezuela. AD - Autonomous University of Barcelona, Barcelona, Spain. AD - University of Barcelona, Barcelona, Spain. AD - NutriWhite Headquarters, Madrid, Spain. FAU - Verzura, Julie AU - Verzura J AD - Universidad de Carabobo (UC), Valencia, Venezuela. AD - Venezuelan Institute for Scientific Research (IVIC), Caracas, Venezuela. AD - National Association of Nutritional Professionals, Berkeley, CA, United States. FAU - White, Mariana AU - White M AD - NutriWhite - International Organization of Immune Nutrition Specialists, Pompano Beach, FL, United States. AD - Universidad Simon Bolivar (USB), Caracas, Venezuela. FAU - Rodriguez, Carol AU - Rodriguez C AD - NutriWhite Headquarters, Caracas, Venezuela. AD - Regis College, Weston, MA, United States. FAU - White, Mercedes AU - White M AD - Department of Assistance and Nutrition, School of Nutrition and Dietetics, Faculty of Medicine, University of Los Andes (ULA), Merida, Venezuela. FAU - Garcia Bravo, Milaidi AU - Garcia Bravo M AD - Department of Assistance and Nutrition, School of Nutrition and Dietetics, Faculty of Medicine, University of Los Andes (ULA), Merida, Venezuela. LA - eng PT - Journal Article PT - Observational Study DEP - 20260525 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (HLA-DQ Antigens) RN - 0 (Immunoglobulin G) RN - 8002-80-0 (Glutens) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *HLA-DQ Antigens/genetics/immunology MH - Female MH - *Immunoglobulin G/blood/immunology MH - Retrospective Studies MH - Male MH - Adult MH - Middle Aged MH - *Wheat Hypersensitivity/immunology/genetics/blood/diagnosis MH - *Glutens/immunology MH - Genetic Predisposition to Disease MH - Triticum/immunology MH - Genotype MH - Biomarkers/blood MH - *Celiac Disease/immunology/genetics/blood MH - Young Adult MH - Adolescent PMC - PMC13243097 OTO - NOTNLM OT - HLA-DQ antigens OT - cross-reactions OT - genetic predisposition to disease OT - immunoglobulin G OT - innate immunity OT - precision medicine OT - real world evidence OT - wheat hypersensitivity COIS- MaW, MeW, and JV are employed by nutriWhite immunonutrition clinic. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/10 06:53 MHDA- 2026/06/15 11:31 PMCR- 2026/05/25 CRDT- 2026/06/10 04:39 PHST- 2026/02/19 00:00 [received] PHST- 2026/03/28 00:00 [revised] PHST- 2026/04/02 00:00 [accepted] PHST- 2026/06/15 11:31 [medline] PHST- 2026/06/10 06:53 [pubmed] PHST- 2026/06/10 04:39 [entrez] PHST- 2026/05/25 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1814097 [doi] PST - epublish SO - Front Immunol. 2026 May 25;17:1814097. doi: 10.3389/fimmu.2026.1814097. eCollection 2026. PMID- 42266546 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260610 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Association between the albumin-to-lymphocyte ratio and short-term mortality in critically Ill pediatric patients: a retrospective cohort study and machine learning analysis. PG - 1795057 LID - 10.3389/fped.2026.1795057 [doi] LID - 1795057 AB - BACKGROUND: Albumin-to-lymphocyte ratio (ALR), integrating nutritional status and immune-inflammatory response, has been proposed as a potential prognostic biomarker in various clinical settings. However, evidence regarding its prognostic value in critically ill pediatric patients remains limited. This study aimed to investigate the association between early ALR and short-term all-cause mortality in pediatric intensive care unit (PICU) patients and to evaluate its predictive utility. METHODS: Clinical data were extracted from a large single-center PICU database including critically ill children admitted between 2010 and 2019. Patients were stratified into tertiles according to ALR measured within the first 24 hours after PICU admission. The primary outcome was 28-day all-cause mortality. Cox proportional hazards models were applied to assess the association between ALR and mortality after adjusting for potential confounders. Restricted cubic spline analyses were conducted to explore potential non-linear relationships. Kaplan-Meier survival curves were used to compare survival across ALR groups. Subgroup analyses were performed to evaluate the robustness of the association. In addition, multiple machine learning models incorporating ALR and other clinical variables were developed to predict 28-day mortality, and model performance was assessed using the area under the receiver operating characteristic curve (AUC). RESULTS: A total of 7,591 critically ill children were included, with an overall 28-day mortality rate of 4.53%. Across ALR tertiles, the intermediate group showed the lowest observed 28-day mortality and the highest survival probability. In the fully adjusted Cox model, both the intermediate and highest tertiles were associated with lower mortality risk than the lowest tertile, with the strongest association observed in the intermediate tertile (T2: HR 0.55, 95% CI 0.42-0.74; T3: HR 0.65, 95% CI 0.49-0.86). Restricted cubic spline analysis revealed a significant non-linear association between ALR and mortality, characterized by a rapid decline in risk at low ALR levels, a nadir in the intermediate range, and a slight increase at higher ALR levels. This pattern was consistent with the Kaplan-Meier analysis, which showed the highest survival probability in the middle ALR tertile. Subgroup analyses showed consistent associations across different clinical strata. Among the machine learning models, the XGBoost model achieved the best discriminative performance, with an AUC of 0.835. In the SHAP-based interpretation, ALR contributed to model prediction and ranked tenth among the selected features. CONCLUSION: As a simple, readily available, and cost-effective biomarker derived from routine laboratory tests, ALR may serve as a complementary tool for early risk stratification and prognostic assessment in the PICU setting. CI - (c) 2026 Chen, Tang, Ye, Chen and Liu. FAU - Chen, Kai AU - Chen K AD - Department of Pediatrics, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang, China. FAU - Tang, Huiyan AU - Tang H AD - Department of Pediatrics, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang, China. FAU - Ye, Yuanyuan AU - Ye Y AD - Department of Pediatrics, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang, China. FAU - Chen, Jie AU - Chen J AD - Department of Biology, Jiaxing Construction Industry School, Jiaxing, Zhejiang, China. FAU - Liu, Jie AU - Liu J AD - Department of Critical Care Medicine, Jiaxing Hospital of Traditional Chinese Medicine, Jiaxing, Zhejiang, China. LA - eng PT - Journal Article DEP - 20260525 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13243273 OTO - NOTNLM OT - albumin-to-lymphocyte ratio OT - machine learning OT - mortality OT - pediatric intensive care unit OT - risk stratification COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/10 06:52 MHDA- 2026/06/10 06:53 PMCR- 2026/05/25 CRDT- 2026/06/10 04:37 PHST- 2026/01/24 00:00 [received] PHST- 2026/04/17 00:00 [revised] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/06/10 06:53 [medline] PHST- 2026/06/10 06:52 [pubmed] PHST- 2026/06/10 04:37 [entrez] PHST- 2026/05/25 00:00 [pmc-release] AID - 10.3389/fped.2026.1795057 [doi] PST - epublish SO - Front Pediatr. 2026 May 25;14:1795057. doi: 10.3389/fped.2026.1795057. eCollection 2026. PMID- 42265933 OWN - NLM STAT- MEDLINE DCOM- 20260808 LR - 20260903 IS - 1600-0412 (Electronic) IS - 0001-6349 (Print) IS - 0001-6349 (Linking) VI - 105 IP - 9 DP - 2026 Sep TI - Population-specific validation of fetal weight formulas: Evidence from a multicenter near-delivery cohort. PG - 1680-1688 LID - 10.1111/aogs.70278 [doi] AB - INTRODUCTION: Accurate ultrasound estimated fetal weight (EFW) supports key perinatal decisions. This study aimed to compare the accuracy of a population-specific formula with that of a widely used global model in pregnancies examined near delivery. MATERIAL AND METHODS: This was a secondary analysis of a prospective Japanese cohort study to develop a new fetal ultrasound biometry reference chart. Fetal ultrasound measurements were obtained by Japan Society of Ultrasonics in Medicine-certified sonographers or under their supervision and submitted to the coordinating center, where EFW was calculated using the Shinozuka and Hadlock-3 formulas. Analyses were restricted to cases with EFW available from both formulas. The primary analysis included examinations within 7 days before delivery; a sensitivity analysis restricted the interval to /= 2 mL.kg(-)(1).d(-)(1)), limiting early drain removal or selective omission under close monitoring. This study aimed to develop and validate an intuitive preoperative nomogram using readily available clinical indicators (e.g., cyst diameter, age) to predict high-drainage risk after robot-assisted RYHJ and support individualized drainage management. METHODS: This single-center retrospective cohort study enrolled 129 children with CDC who underwent da Vinci robot-assisted RYHJ. Based on weight-adjusted daily drain output, patients were divided into low-drainage (< 2 mL.kg(-)(1).d(-)(1), n = 30) and high-drainage (>/= 2 mL.kg(-)(1).d(-)(1), n = 99) groups. Potential predictors were identified via univariate and multivariate logistic regression and incorporated into a nomogram. Model performance was assessed using the area under the receiver operating characteristic curve (AUC) and calibration plots. RESULTS: Multivariate analysis identified younger age as an independent predictor of high drainage output (OR = 0.983, 95% CI: 0.972-0.994), and larger cyst diameter as a potential predictor showing a trend toward association (OR = 1.321, 95% CI: 0.979-1.783). The final nomogram, incorporating cyst diameter, age, body mass index (BMI), hemoglobin (HGB), and globulin (GLB), showed good discrimination (AUC = 0.753) and calibration. The optimal risk threshold was 79.88%, yielding a specificity of 75.9%, and, using an optimal threshold, identifies low-risk patients suitable for early drain removal protocols to guide individualized drainage management. CONCLUSION: We have developed and validated a nomogram model based on "cyst diameter + age" (supplemented by BMI, HGB, and GLB) that enables noninvasive, precise assessment of high-drainage risk following robot-assisted RYHJ. Notably, the model identifies a low-risk subset-older children with smaller cysts-for whom early drain removal (e.g., within 24-48 h) is safe, and in whom selective drain omission could be prospectively evaluated under rigorous monitoring. This risk-stratified approach has the potential to reduce drain-related complications and optimize ERAS pathways following robot-assisted RYHJ. As this is an internal validation only, external validation in independent cohorts is warranted before clinical implementation. CI - (c) 2026. The Author(s). FAU - Zhang, Jing AU - Zhang J AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - You, Tao AU - You T AD - Medical Department, School of Medicine, Wuhan University of Science and Technology, Wuhan, Hubei, 430070, China. FAU - Qin, Xinke AU - Qin X AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - Liang, Chong AU - Liang C AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - Zhu, Zhenchuang AU - Zhu Z AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - Liu, Xin AU - Liu X AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - Ji, Siqi AU - Ji S AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - He, Xiaoqiong AU - He X AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - Duan, Xufei AU - Duan X AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. FAU - Yan, Xueqiang AU - Yan X AD - Department of Hepatobiliary and Oncology Surgery, Wuhan Children's Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, 430016, China. yanxueqiang1@163.com. LA - eng GR - 2025FEYJS005/the Laboratory of Hepatobiliary and Pancreatic Diseases in Children/ PT - Journal Article PT - Validation Study DEP - 20260610 PL - England TA - BMC Surg JT - BMC surgery JID - 100968567 SB - IM MH - Humans MH - *Nomograms MH - *Choledochal Cyst/surgery/pathology MH - Retrospective Studies MH - *Drainage MH - Infant MH - Female MH - *Anastomosis, Roux-en-Y/methods MH - Male MH - Child, Preschool MH - Child MH - *Robotic Surgical Procedures MH - *Postoperative Complications/etiology MH - *Jejunostomy/methods MH - Age Factors PMC - PMC13474786 OTO - NOTNLM OT - Choledochal cyst (CDC) OT - Enhanced recovery after surgery (ERAS) OT - High drainage output OT - Nomogram OT - Pediatric surgery OT - Robot-assisted Roux-en-Y hepaticojejunostomy (RYHJ) COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Wuhan Children's Hospital of Huazhong University of Science and Technology (Approval No. 2024R030-E01). Owing to the retrospective design of the study, the need for informed consent was waived. Owing to the retrospective design of the study, the need for informed consent was waived by the ethics committee of Wuhan Children's Hospital of Huazhong University of Science and Technology. The study was conducted according to the principles of the Declaration of Helsinki. Consent for publication: Not Applicable. This is a retrospective study. Competing interests: The authors declare no competing interests. EDAT- 2026/06/10 06:54 MHDA- 2026/08/14 05:38 PMCR- 2026/06/10 CRDT- 2026/06/10 00:10 PHST- 2025/11/17 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/08/14 05:38 [medline] PHST- 2026/06/10 06:54 [pubmed] PHST- 2026/06/10 00:10 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - 10.1186/s12893-026-03912-1 [pii] AID - 3912 [pii] AID - 10.1186/s12893-026-03912-1 [doi] PST - epublish SO - BMC Surg. 2026 Jun 10;26(1):543. doi: 10.1186/s12893-026-03912-1. PMID- 42264886 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261027 IS - 1541-3144 (Electronic) IS - 0194-2638 (Linking) VI - 46 IP - 6 DP - 2026 TI - Functional Exercise Performance in Children with Cerebral Palsy: Is the 1-Minute Sit-to-Stand Test an Alternative to the 6-Minute Walk Test? PG - 1390-1405 LID - 10.1080/01942638.2026.2682292 [doi] AB - OBJECTIVES: This study examined the validity, test-retest reliability, and clinical feasibility of the 1-minute sit-to-stand test (1MSTS) as a practical alternative to the 6-minute walk test (6MWT) for assessing functional exercise capacity in children with cerebral palsy (CP). METHODS: Seventy-eight children aged 5-18 years with spastic hemiplegic CP (Gross Motor Function Classification System I-II) completed the 1MSTS and 6MWT in random order on the same day. Test-retest reliability of the 1MSTS was evaluated using the intraclass correlation coefficient (ICC), standard error of measurement (SEM), and minimal detectable change (MDC). Construct validity was assessed using correlation and linear regression analyses. RESULTS: The 1MSTS demonstrated good test-retest reliability (ICC = 0.78), with an SEM of 1.49 repetitions and an MDC(95) of 4.12 repetitions. A very strong association was observed between 1MSTS and 6MWT performances (rho = 0.886, p < .001). Linear regression analysis further demonstrated that 6MWT distance explained approximately 80% of the variance in 1MSTS repetitions (R(2) = 0.799). These findings indicate that the 1MSTS captures functional exercise capacity assessed by the 6MWT. CONCLUSION: The 1MSTS is a valid, reliable, and clinically feasible alternative to the 6MWT for evaluating functional exercise capacity in children with spastic hemiplegic CP. TRIAL REGISTRATION: ClinicalTrials.gov (NCT07136129). FAU - Ergun, Betul AU - Ergun B AUID- ORCID: 0000-0001-7212-2937 AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Firat University, Elazig, Turkey. FAU - Baykan Copuroglu, Ozge AU - Baykan Copuroglu O AUID- ORCID: 0000-0003-1014-8845 AD - Incesu Ayse ve Saffet Arslan Health Services Vocational School, Kayseri University, Kayseri, Turkey. FAU - Baykan, Muge AU - Baykan M AUID- ORCID: 0000-0002-8299-6926 AD - Recep Tayyip Erdogan University Training and Research Hospital, Rize, Turkey. FAU - Gurer, Feyza AU - Gurer F AUID- ORCID: 0000-0002-8539-607X AD - Department of Health Management, Faculty of Health Sciences, Yuksek Ihtisas University, Ankara, Turkey. FAU - Abakay, Hanife AU - Abakay H AUID- ORCID: 0000-0003-4047-7965 AD - Physiotherapy Program, Incesu Ayse ve Saffet Arslan Health Services Vocational School, Kayseri University, Kayseri, Turkey. LA - eng SI - ClinicalTrials.gov/NCT07136129 PT - Journal Article DEP - 20260609 PL - England TA - Phys Occup Ther Pediatr JT - Physical & occupational therapy in pediatrics JID - 8109120 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology MH - Child MH - Female MH - Male MH - Reproducibility of Results MH - Adolescent MH - Child, Preschool MH - *Exercise Test/methods MH - Walk Test MH - Feasibility Studies MH - *Exercise Tolerance/physiology OTO - NOTNLM OT - Cerebral palsy OT - functional exercise capacity OT - sit-to-stand test OT - test-retest reliability EDAT- 2026/06/10 06:52 MHDA- 2026/10/27 05:29 CRDT- 2026/06/09 21:04 PHST- 2026/10/27 05:29 [medline] PHST- 2026/06/10 06:52 [pubmed] PHST- 2026/06/09 21:04 [entrez] AID - 10.1080/01942638.2026.2682292 [doi] PST - ppublish SO - Phys Occup Ther Pediatr. 2026;46(6):1390-1405. doi: 10.1080/01942638.2026.2682292. Epub 2026 Jun 9. PMID- 42264873 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260612 IS - 1558-0776 (Electronic) IS - 1071-9091 (Linking) VI - 58 DP - 2026 Jul TI - Improving concussion recognition in youth sports: the role of parents, coaches, and community education. PG - 101293 LID - S1071-9091(26)00037-9 [pii] LID - 10.1016/j.spen.2026.101293 [doi] AB - The lifelong benefits of youth sports include physical fitness and improved psychological and social skills. However, sports related risks, such as sport related concussion (SRC), must be continuously evaluated. The developing brain is uniquely vulnerable to SRC, with potential negative impacts across three fundamental domains: cognition, emotion, and learning. Surprisingly, SRC remains significantly underreported and clinically underestimated. This trend can be reversed through education focused on two critical pillars: early detection and timely reporting. However, the passive transfer of information, where athletes may feel pressured to suppress symptoms, is of limited value. SRC underreporting is heavily influenced by cultural and social factors, peer pressure, and coaching attitudes. While international legislation and guidelines vary, outcomes are optimized when legislative efforts are integrated with rigorous supervision, formal education, and medical infrastructure. The leadership of coaches and health professionals enhances team communication, athlete assertiveness, and reporting rates. In the absence of healthcare professionals, adults managing a suspected SRC should immediately remove the athlete from play and utilize the Concussion Recognition Tool 6 (CRT6) for assessment. Ultimately, effective pediatric SRC prevention requires a holistic strategy encompassing education, validated guidelines, medical support, and safety culture. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Baltar Yanes, Federico AU - Baltar Yanes F AD - Unidad Academica de Neuropediatria, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay. Electronic address: fedebaltar@gmail.com. FAU - Vidarte, Florencia Perez AU - Vidarte FP AD - Unidad Academica de Neuropediatria, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay. FAU - Rivandeneira-Limongi, Alina AU - Rivandeneira-Limongi A AD - Boston University Chobanian and Avedisian School of Medicine, Boston Medical Center. FAU - Piccardo, Pedro AU - Piccardo P AD - Unidad Academica de Neuropediatria, Facultad de Medicina, Universidad de la Republica, Montevideo, Uruguay. FAU - Torres, Alcy AU - Torres A AD - Boston University Chobanian and Avedisian School of Medicine, Boston Medical Center. LA - eng PT - Journal Article PT - Review DEP - 20260425 PL - United States TA - Semin Pediatr Neurol JT - Seminars in pediatric neurology JID - 9441351 SB - IM MH - Humans MH - *Brain Concussion/diagnosis/prevention & control MH - *Athletic Injuries/diagnosis/prevention & control MH - *Parents MH - *Youth Sports/injuries MH - *Mentoring MH - *Health Education OTO - NOTNLM OT - Brain concussion OT - Healthcare education OT - Safety culture OT - Sports COIS- Declaration of competing interest The authors declare that they have no conflicts of interest related to the work presented. EDAT- 2026/06/10 06:52 MHDA- 2026/06/12 13:01 CRDT- 2026/06/09 21:04 PHST- 2026/03/24 00:00 [received] PHST- 2026/04/24 00:00 [revised] PHST- 2026/04/24 00:00 [accepted] PHST- 2026/06/12 13:01 [medline] PHST- 2026/06/10 06:52 [pubmed] PHST- 2026/06/09 21:04 [entrez] AID - S1071-9091(26)00037-9 [pii] AID - 10.1016/j.spen.2026.101293 [doi] PST - ppublish SO - Semin Pediatr Neurol. 2026 Jul;58:101293. doi: 10.1016/j.spen.2026.101293. Epub 2026 Apr 25. PMID- 42264869 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260612 IS - 1558-0776 (Electronic) IS - 1071-9091 (Linking) VI - 58 DP - 2026 Jul TI - Age-appropriate assessment of concussion in children and adolescents. PG - 101267 LID - S1071-9091(26)00011-2 [pii] LID - 10.1016/j.spen.2026.101267 [doi] AB - Sport-related concussion (SRC) in children and adolescents presents unique diagnostic challenges due to heterogeneous clinical presentations and rapid neurodevelopmental trajectories. This focused review emphasizes that diagnosis fundamentally relies on symptomatic reporting and objective physiological assessments spanning multiple domains, integrating age-specific tools such as the revised Sport Concussion Assessment Tool 6 (SCAT6) and the Sport Concussion Office Assessment Tool 6 (SCOAT6). While the SCAT6 (ages >13) and Child SCAT6 (ages 8-12) are optimized for acute evaluation within the initial 72 hours, the SCOAT6 framework facilitates comprehensive multidomain assessment during the subacute phase (3-30 days). Clinicians must prioritize visio-vestibular and oculomotor screenings, as dysfunction in these areas is highly prevalent and associated with protracted recovery. For younger children (ages 5-9), the specialized VOMS-Child (VOMS-C) uses developmentally appropriate binary symptom reporting to accurately identify injury. Management paradigms have shifted toward active rehabilitation; the cornerstone of modern care is Sub-Symptom Threshold Aerobic Exercise (STTAE), which, when initiated within 2-10 days post-injury, significantly accelerates recovery. While computerized neurocognitive testing and emerging biomarkers offer insights, clinical decision-making must remain anchored in validated functional assessments while accounting for suboptimal effort in youth populations. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Beletanga, Maria AU - Beletanga M AD - Universidad Internacional del Ecuador, Quito, Ecuador. Electronic address: lola.beletanga@gmail.com. FAU - Vaca, Andrea AU - Vaca A AD - Universidad Internacional del Ecuador, Quito, Ecuador. FAU - Mohanty, Mugdha AU - Mohanty M AD - University of Massachusetts (UMASS), Worcester, MA, USA. FAU - Garrido, Gabriel AU - Garrido G AD - Universidad de las Americas (UDLA), Quito, Ecuador. FAU - Lopez, Dennis AU - Lopez D AD - Hospital Metropolitano, Quito, Ecuador. FAU - Roman, Marcelo AU - Roman M AD - Hospital Metropolitano, Quito, Ecuador. FAU - Torres, Alcy R AU - Torres AR AD - Boston University Chobanian & Avedisian School of Medicine, Boston, MA, USA. LA - eng PT - Journal Article PT - Review DEP - 20260322 PL - United States TA - Semin Pediatr Neurol JT - Seminars in pediatric neurology JID - 9441351 SB - IM MH - Humans MH - Child MH - *Brain Concussion/diagnosis MH - Adolescent MH - *Athletic Injuries/diagnosis MH - Age Factors OTO - NOTNLM OT - Adolescent OT - Brain concussion OT - Child OT - Exercise OT - Pediatric neurology OT - Rehabilitation OT - SCAT6 OT - SCOAT6 OT - Sport-related concussion OT - Vestibular/Ocular Motor Screening (VOMS) COIS- Declaration of competing interest There are no personal, professional, or financial affiliations with sports organizations that could bias the clinical recommendations presented in this manuscript. EDAT- 2026/06/10 06:54 MHDA- 2026/06/13 00:38 CRDT- 2026/06/09 21:04 PHST- 2026/02/07 00:00 [received] PHST- 2026/03/21 00:00 [revised] PHST- 2026/03/21 00:00 [accepted] PHST- 2026/06/13 00:38 [medline] PHST- 2026/06/10 06:54 [pubmed] PHST- 2026/06/09 21:04 [entrez] AID - S1071-9091(26)00011-2 [pii] AID - 10.1016/j.spen.2026.101267 [doi] PST - ppublish SO - Semin Pediatr Neurol. 2026 Jul;58:101267. doi: 10.1016/j.spen.2026.101267. Epub 2026 Mar 22. PMID- 42264793 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260612 IS - 1532-9283 (Electronic) IS - 1360-8592 (Linking) VI - 47 DP - 2026 Jul TI - Kinetic-functional assessment of the adolescent idiopathic scoliosis: a cohort study. PG - 199-204 LID - S1360-8592(26)00051-3 [pii] LID - 10.1016/j.jbmt.2026.03.036 [doi] AB - INTRODUCTION: It is estimated that 1 to 3% of the world's population is diagnosed with idiopathic scoliosis, with a higher prevalence in females and a higher index of curves in the right thoracic region. Diagnosis and clinical follow-up are based on radiographic analysis and measurement of the Cobb angle, which is considered the gold standard for classifying scoliotic severity. OBJECTIVE: This study investigated the applicability and feasibility of the kinetic-functional examination in patients with adolescent idiopathic scoliosis, considering the main functional tests described in the literature. METHODS: It was a cross-sectional, quantitative cohort study (CAAE xxxxxxxxxxxxxxxxx) involving individuals of both sexes, aged between 10 and 14 years, who had a diagnosis of idiopathic scoliosis of the adolescent confirmed by radiographic examination (Cobb angle between 10 degrees and 50 degrees ). Statistical significance was set p < 0.05. RESULTS: A total of 157 individuals participated in the study, 77.7% were female and 57.9% were considered underweight according to body mass index. Regarding the degree of severity of the curve, 61.8% of the adolescents had a moderate scoliotic curve. A trend towards a reduction in spine flexibility was observed as the severity of the curvature increased, especially in mild and moderate curves, while the strength tests showed negative values, with no marked differences between the severity groups. CONCLUSION: The standardized application of functional tests ensures reliability and reproducibility of the results, and ensures the patient's performance, reducing biases, favoring clinical validity and assisting in the accurate identification of functional deficits. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Silva, Darlan Gonzaga da AU - Silva DGD AD - State University of Bahia (UNEB), Salvador, BA, Brazil. Electronic address: darlagfisio@gmail.com. FAU - Nascimento, Lara Galvao AU - Nascimento LG AD - Scoliosis Rehabilitation Clinical Center, Bahia, BA, Brazil. Electronic address: laragalvao26@gmail.com. FAU - da Silva, Beatriz Cerqueira AU - da Silva BC AD - Scoliosis Rehabilitation Clinical Center, Bahia, BA, Brazil. Electronic address: beatrizcerqueira.fisio@gmail.com. FAU - Andrade, Rodrigo Mantelatto AU - Andrade RM AD - Scoliosis Rehabilitation Clinical Center, Sao Paulo, SP, Brazil. Electronic address: rodrigoandradefisioterapia@gmail.com. FAU - Paineiras-Domingos, Laisa Liane AU - Paineiras-Domingos LL AD - Postgraduate Program in Medicine and Health, Faculty of Medicine of Bahia, Federal University of Bahia (UFBA), Salvador, BA, Brazil. Electronic address: laisa.liane@ufba.br. FAU - Lessa, Paulo Itamar Ferraz AU - Lessa PIF AD - State University of Bahia (UNEB), Salvador, BA, Brazil; Scoliosis Rehabilitation Clinical Center, Bahia, BA, Brazil. Electronic address: plessa@uneb.br. LA - eng PT - Journal Article DEP - 20260401 PL - United States TA - J Bodyw Mov Ther JT - Journal of bodywork and movement therapies JID - 9700068 SB - IM MH - Humans MH - *Scoliosis/physiopathology/diagnosis MH - Female MH - Adolescent MH - Cross-Sectional Studies MH - Child MH - Male MH - Cohort Studies MH - Range of Motion, Articular/physiology MH - Severity of Illness Index MH - Muscle Strength/physiology MH - Spine/physiopathology MH - Body Mass Index OTO - NOTNLM OT - Adolescent idiopathic scoliosis OT - Flexibility OT - Functional tests OT - Mobility OT - Muscle strength COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/10 06:52 MHDA- 2026/06/12 18:40 CRDT- 2026/06/09 21:02 PHST- 2026/02/24 00:00 [received] PHST- 2026/03/30 00:00 [revised] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/06/12 18:40 [medline] PHST- 2026/06/10 06:52 [pubmed] PHST- 2026/06/09 21:02 [entrez] AID - S1360-8592(26)00051-3 [pii] AID - 10.1016/j.jbmt.2026.03.036 [doi] PST - ppublish SO - J Bodyw Mov Ther. 2026 Jul;47:199-204. doi: 10.1016/j.jbmt.2026.03.036. Epub 2026 Apr 1. PMID- 42263736 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20260918 IS - 1938-2480 (Electronic) IS - 1538-8506 (Linking) VI - 39 IP - 12 DP - 2026 Oct TI - Comparison of Long-Term Tunnel Widening in Anterior Cruciate Ligament Reconstruction Using Allograft and Hamstring Autograft: More Than 10 Years' Mean Follow-Up. PG - 654-661 LID - 10.1055/a-2886-8283 [doi] AB - Bone tunnel widening following anterior cruciate ligament reconstruction (ACLR) is a well-recognized radiological phenomenon with multifactorial etiology. While concerns have been raised regarding potentially greater tunnel enlargement with allografts due to immune-mediated responses, evidence remains inconsistent. This study compared long-term femoral and tibial tunnel widening between hamstring autograft and allograft reconstruction at a mean follow-up exceeding 10 years. A retrospective analysis was conducted on 60 patients who underwent primary ACLR between 2011 and 2016 by a single surgeon. Group I consisted of 29 patients receiving soft tissue allografts (Achilles, tibialis anterior, or peroneus longus tendons), while Group II included 31 patients with four-strand hamstring autografts. All procedures utilized identical fixation: adjustable-loop suspension device (femur) and bioabsorbable interference screw with tibial staple. Patients with previous knee surgery, re-rupture, clinical graft failure, concomitant ligament procedures, or significant chondral lesions were excluded. Computed tomography scans at final follow-up (mean: 10.7 years) were analyzed using standardized oblique reformatted sections perpendicular to tunnel axes. Six measurements per tunnel (three levels x two planes) were averaged. Tunnel widening was expressed as absolute change (Deltamm) and percentage relative to intraoperative drill bit diameter. Two blinded orthopedic surgeons performed independent measurements. Statistical analysis included Mann-Whitney U test, analysis of covariance adjusted for body mass index (BMI) and follow-up duration, categorical threshold analysis, and correlation analysis with Bonferroni correction. No significant differences were observed between groups for tibial widening (allograft 2.07 +/- 1.75 mm vs. autograft 2.31 +/- 1.72 mm, p = 0.500) or femoral widening (1.73 +/- 1.48 mm vs. 2.30 +/- 1.63 mm, p = 0.157). After adjustment for BMI and follow-up duration, between-group differences remained nonsignificant (all adjusted p > 0.0125 after Bonferroni correction). Categorical distribution across predefined thresholds showed similar patterns. Initial tunnel diameter inversely correlated with tibial percentage widening (r =-0.373, p = 0.003). Interobserver reliability was excellent (intraclass correlation coefficient: 0.89-0.92). At long-term follow-up, allograft and hamstring autograft demonstrated comparable tunnel widening patterns, suggesting graft selection should prioritize clinical factors beyond tunnel enlargement concerns. CI - Thieme. All rights reserved. FAU - Ipek, Enver AU - Ipek E AUID- ORCID: 0000-0001-6205-1207 AD - Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Department of Orthopedics and Traumatology, Turkey. FAU - Altuntas, Yusuf AU - Altuntas Y AD - Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Department of Orthopedics and Traumatology, Turkey. FAU - Balkanli, Bahadir AU - Balkanli B AD - Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Department of Orthopedics and Traumatology, Turkey. FAU - Yuksel, Mehmet Alp AU - Yuksel MA AD - Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Department of Orthopedics and Traumatology, Turkey. FAU - Akbas, Harun AU - Akbas H AD - Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Department of Orthopedics and Traumatology, Turkey. FAU - Eren, Osman Tugrul AU - Eren OT AD - Istanbul Sisli Hamidiye Etfal Training and Research Hospital, Department of Orthopedics and Traumatology, Turkey. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260609 PL - Germany TA - J Knee Surg JT - The journal of knee surgery JID - 101137599 SB - IM MH - Humans MH - Retrospective Studies MH - *Anterior Cruciate Ligament Reconstruction/methods MH - Female MH - Follow-Up Studies MH - *Hamstring Tendons/transplantation MH - Adult MH - Allografts MH - Male MH - Autografts MH - *Tibia/surgery/diagnostic imaging MH - Transplantation, Autologous MH - *Femur/surgery/diagnostic imaging MH - *Anterior Cruciate Ligament Injuries/surgery MH - Young Adult MH - Tomography, X-Ray Computed MH - Transplantation, Homologous MH - Adolescent COIS- The authors declare that they have no conflict of interest. EDAT- 2026/06/10 06:52 MHDA- 2026/09/18 23:36 CRDT- 2026/06/09 19:03 PHST- 2026/09/18 23:36 [medline] PHST- 2026/06/10 06:52 [pubmed] PHST- 2026/06/09 19:03 [entrez] AID - 10.1055/a-2886-8283 [doi] PST - ppublish SO - J Knee Surg. 2026 Oct;39(12):654-661. doi: 10.1055/a-2886-8283. Epub 2026 Jun 9. PMID- 42262874 OWN - NLM STAT- MEDLINE DCOM- 20260910 LR - 20260922 IS - 1555-905X (Electronic) IS - 1555-9041 (Print) IS - 1555-9041 (Linking) VI - 21 IP - 9 DP - 2026 Sep 1 TI - Evaluation of the Association between Age, Sex, and d -Amino Acid-Based Estimation of GFR. PG - 1545-1553 LID - 10.2215/CJN.0000001108 [doi] AB - KEY POINTS: Blood d -serine and d -asparagine reflect GFR, reportedly with stable kinetics minimally influenced by age and tubular transport. d -Amino acid-based eGFR minimizes age and sex biases, a distinct advantage over conventional models. d -Amino acid-based eGFR holds broad clinical potential across all ages and populations. BACKGROUND: eGFR is challenging because of its dependence on age and body composition, especially in pediatric and elderly populations. Recently, d -serine and d -asparagine, rare amino acid enantiomers, have been identified as GFR biomarkers characterized by their ideal kidney clearance and minimal impacts of body size. We investigated the impact of age and sex on GFR estimation using these d -amino acids. METHODS: We analyzed data from a cross-sectional observational cohort: 366 adult Japanese living kidney transplant donors and recipients. Using a dataset of 244 patients, we developed GFR estimation formulae on the basis of blood levels of d -serine and d -asparagine using linear regression analyses and validated the formulas' performance in 122 patients. RESULTS: The d -amino acid - based equation was established as 60.4x d -Ser -0.450 x d -Asn -0.304 x0.916 (if female), in which age did not significantly improve model performance and the impact of sex was minor. The performance of the established equations was equivalent to that of creatinine-based equations: bias (absolute difference), 9.1 (8.0-11.2); precision (interquartile range of bias), 11.1 (8.8-14.2); and accuracy (ratios of 30% different from measured GFR [P 30 ]), 0.82 (0.73-0.89). CONCLUSIONS: d -Amino acid-based estimation of GFR exhibits minimal empirical association with age and sex, offering a distinct advantage over models dependent on these demographic variables. This stability may support its broad clinical utility as a reliable diagnostic tool across all age groups and diverse populations. CI - Copyright (c) 2026 by the American Society of Nephrology. FAU - Fukae, Shota AU - Fukae S AD - Department of Urology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Sakai, Shinsuke AU - Sakai S AUID- ORCID: 0009-0004-3295-0390 AD - Department of Nephrology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Tanaka, Ryo AU - Tanaka R AUID- ORCID: 0000-0003-1144-7820 AD - Department of Urology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Taniguchi, Ayumu AU - Taniguchi A AUID- ORCID: 0000-0001-7869-1786 AD - Department of Urology, Juntendo University Urayasu Hospital, Chiba, Japan. FAU - Kawamura, Masataka AU - Kawamura M AUID- ORCID: 0000-0003-1454-0588 AD - Department of Urology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Kimura-Ohba, Shihoko AU - Kimura-Ohba S AD - Department of Virology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Nakazawa, Shigeaki AU - Nakazawa S AUID- ORCID: 0000-0001-5857-3483 AD - Department of Urology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Horio, Masaru AU - Horio M AD - Department of Nephrology, Kansai Medical Hospital, Osaka, Japan. FAU - Takahara, Shiro AU - Takahara S AD - Department of Renal Transplantation, Kansai Medical Clinic, Osaka, Japan. FAU - Imamura, Ryoichi AU - Imamura R AUID- ORCID: 0000-0002-8782-9852 AD - Department of Urology, Nagasaki University Graduate School of Medicine, Nagasaki, Japan. FAU - Yamada, Muneharu AU - Yamada M AUID- ORCID: 0000-0003-0483-0012 AD - Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan. FAU - Oda, Takashi AU - Oda T AUID- ORCID: 0000-0002-6131-7752 AD - Department of Nephrology and Blood Purification, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan. FAU - Konno, Osamu AU - Konno O AUID- ORCID: 0000-0001-7706-0616 AD - Department of Kidney Transplantation Surgery, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan. FAU - Iwamoto, Hitoshi AU - Iwamoto H AD - Department of Kidney Transplantation Surgery, Kidney Disease Center, Tokyo Medical University Hachioji Medical Center, Tokyo, Japan. FAU - Isaka, Yoshitaka AU - Isaka Y AUID- ORCID: 0000-0002-0820-7167 AD - Department of Nephrology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Mizui, Masayuki AU - Mizui M AUID- ORCID: 0000-0003-2543-8108 AD - Department of Nephrology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Nonomura, Norio AU - Nonomura N AD - Department of Urology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Kakuta, Yoichi AU - Kakuta Y AUID- ORCID: 0000-0001-5339-4312 AD - Department of Urology, The University of Osaka Graduate School of Medicine, Osaka, Japan. FAU - Kimura, Tomonori AU - Kimura T AUID- ORCID: 0000-0001-8186-094 AD - Department of Nephrology, The University of Osaka Graduate School of Medicine, Osaka, Japan. AD - Department of Nephrology, Kansai Medical Hospital, Osaka, Japan. AD - Department of Renal Transplantation, Kansai Medical Clinic, Osaka, Japan. LA - eng GR - 21H02935/Japan Society for the Promotion of Science/ GR - NA/Manpei Suzuki Diabetes Foundation/ PT - Journal Article PT - Observational Study DEP - 20260609 PL - United States TA - Clin J Am Soc Nephrol JT - Clinical journal of the American Society of Nephrology : CJASN JID - 101271570 RN - 452VLY9402 (Serine) RN - 7006-34-0 (Asparagine) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Glomerular Filtration Rate MH - Female MH - Male MH - Age Factors MH - Cross-Sectional Studies MH - Sex Factors MH - Kidney Transplantation MH - Middle Aged MH - *Serine/blood MH - Adult MH - *Asparagine/blood MH - Aged MH - Biomarkers/blood MH - Linear Models PMC - PMC13549483 OTO - NOTNLM OT - CKD OT - transplantation COIS- Disclosure forms, as provided by each author, are available with the online version of the article at http://links.lww.com/CJN/C758. EDAT- 2026/06/09 18:44 MHDA- 2026/09/10 17:42 PMCR- 2026/09/01 CRDT- 2026/06/09 12:03 PHST- 2026/01/28 00:00 [received] PHST- 2026/06/04 00:00 [accepted] PHST- 2026/09/10 17:42 [medline] PHST- 2026/06/09 18:44 [pubmed] PHST- 2026/06/09 12:03 [entrez] PHST- 2026/09/01 00:00 [pmc-release] AID - 01277230-990000000-00942 [pii] AID - CJASN-2026-000141 [pii] AID - 10.2215/CJN.0000001108 [doi] PST - ppublish SO - Clin J Am Soc Nephrol. 2026 Sep 1;21(9):1545-1553. doi: 10.2215/CJN.0000001108. Epub 2026 Jun 9. PMID- 42261973 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260821 IS - 2153-2176 (Electronic) IS - 2153-2168 (Print) IS - 2153-2168 (Linking) VI - 22 IP - 4 DP - 2026 Jun TI - Family-Based Behavioral Treatment for Childhood Obesity Adapted to Align with the MOHealthNet Medicaid Benefit: Results of the Missouri Childhood Obesity Research Demonstration Study. PG - 211-222 LID - 10.1177/21532176261450310 [doi] AB - BACKGROUND: This study leveraged a novel Missouri Medicaid (MOHealthNet) benefit to adapt and implement evidence-based family-based behavioral treatment (FBT) within health care settings in alignment with policy requirements. METHODS: In a nonrandomized matched-comparison trial, 108 parent-child dyads participated in FBT, and 92 dyads attended at least one session. Licensed Clinical Social Workers or Registered Dietitian Nutritionists offered 26-33 FBT hours delivered virtually over 6-12 months to Medicaid-insured patients in an urban and rural pediatric health system in Missouri. The matched-comparison group included 186 participants. The Reach, Effectiveness, Adoption, Implementation, and Maintenance framework (RE-AIM) framework was used to evaluate effectiveness (primary) and reach (secondary) and explore adoption, implementation, and maintenance. RESULTS: Children in the FBT group reduced their percent over median body mass index (BMI) compared with the matched comparison group (mean reduction: -3.9 +/- 1.4, d = -0.42). Within the FBT group, participants also demonstrated improvements in coping with teasing, health-related quality of life, and family health habits (all p < 0.05). Families rated the program as highly acceptable. Reach data indicated enrolled patients had similar BMI, sex, and ethnic backgrounds compared with eligible but non-enrolled patients (ps > 0.301). CONCLUSIONS: Data demonstrate the feasibility of adopting and implementing FBT within health care systems and inform efforts to support maintenance. FBT reached a diverse population of families receiving Medicaid in pediatric primary care settings and was associated with greater improvements in youth weight outcomes compared with a matched comparison group. Adaptations made to align with the benefit may have reduced the magnitude of effects; however, this policy provides an opportunity to deliver FBT within primary care settings and expand access. FAU - Dreyer Gillette, Meredith L AU - Dreyer Gillette ML AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Kansas City, University of Missouri Kansas City, Kansas City, MO, USA. FAU - Button, Alyssa M AU - Button AM AD - Children's Hospital of Richmond, Healthy Lifestyles Center, Virginia Commonwealth University, Richmond, VA, USA. FAU - Staiano, Amanda E AU - Staiano AE AD - Department of Population and Public Health Sciences, Pennington Biomedical Research Center, Baton Rouge, LA, USA. FAU - Nelson, Lisa C AU - Nelson LC AD - Freeman Health System, Joplin, MO, USA. FAU - Carlson, Jordan A AU - Carlson JA AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Hospital, Children's Mercy Kansas City, University of Missouri Kansas City, Kansas City, MO, USA. FAU - Dean, Kelsey M AU - Dean KM AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Kansas City, Kansas City, MO, USA. FAU - Bullard, Sarah E AU - Bullard SE AD - Children's Mercy Kansas City, Kansas City, MO, USA. FAU - Monocello, Lawrence T AU - Monocello LT AD - Department of Anthropology, Texas A&M University, College Station, TX, USA. FAU - Beyl, Robbie AU - Beyl R AD - Pennington Biomedical Research Center, Baton Rouge, LA, USA. FAU - Welch, R Robinson AU - Welch RR AD - Washington University in St. Louis, St. Louis, MO, USA. FAU - Hampl, Sarah E AU - Hampl SE AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Kansas City, University of Missouri Kansas City, Kansas City, MO, USA. FAU - Wilfley, Denise E AU - Wilfley DE AUID- ORCID: 0000-0002-3599-8689 AD - Washington University in St. Louis, St. Louis, MO, USA. CN - MO CORD Research Group LA - eng GR - T32 HL130357/HL/NHLBI NIH HHS/United States GR - U18 DP006425/DP/NCCDPHP CDC HHS/United States GR - P30 DK072476/DK/NIDDK NIH HHS/United States GR - U54 GM104940/GM/NIGMS NIH HHS/United States GR - UL1 TR002345/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20260609 PL - United States TA - Child Obes JT - Childhood obesity (Print) JID - 101542497 SB - IM MH - Humans MH - *Medicaid MH - Female MH - Male MH - Missouri/epidemiology MH - United States MH - Child MH - *Pediatric Obesity/therapy/psychology MH - *Behavior Therapy/methods MH - *Family Therapy/methods MH - Adolescent PMC - PMC13372312 MID - NIHMS2178626 OTO - NOTNLM OT - Medicaid OT - adoption OT - behavioral health OT - family-based treatment OT - obesity treatment OT - reach COIS- Author Disclosure StatementNo competing financial interests exist. EDAT- 2026/06/09 12:49 MHDA- 2026/06/25 06:37 PMCR- 2026/07/15 CRDT- 2026/06/09 08:03 PHST- 2026/06/25 06:37 [medline] PHST- 2026/06/09 12:49 [pubmed] PHST- 2026/06/09 08:03 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - 10.1177/21532176261450310 [doi] PST - ppublish SO - Child Obes. 2026 Jun;22(4):211-222. doi: 10.1177/21532176261450310. Epub 2026 Jun 9. PMID- 42261970 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20260817 IS - 1939-3229 (Electronic) IS - 1939-3210 (Linking) VI - 19 IP - 3 DP - 2026 Sep TI - Heavy metals and preservatives in commercial yoghurt from northern Iraq. PG - 251-261 LID - 10.1080/19393210.2026.2679459 [doi] AB - Pb and Cd occurrence, as well as sodium benzoate, potassium sorbate and nitrate concentrations, were investigated in 75 commercially available yogurts from the Kurdistan region of Iraq. Validated ICP-MS and HPLC-UV methods revealed good linearity (R(2) > 0.995), satisfactory recoveries (90-108%) and appropriate limits of detection. Pb and Cd levels were below maximum limits as established by the European Commission and the Codex Alimentarius. Detection of preservatives in plain yoghurt was not interpreted as straightforward regulatory compliance, as it may indicate unauthorized additive use, carry-over, or product-category/labelling inconsistency. Exposure assessment indicated low non-carcinogenic risk for adults. However, children showed higher relative exposure due to lower body weight, with only the HI value for children in the Sulaymaniyah region marginally exceeding 1. These findings highlight the importance of continuous monitoring and refined evaluation of cumulative dietary exposure. It also provides baseline data for regional food safety assessment and risk management. FAU - Qader, Muzhda Qasim AU - Qader MQ AUID- ORCID: 0000-0002-3561-7137 AD - Department of Public Health, Hawler Medical University, Erbil, Iraq. FAU - Othman, Ahmed Jamal AU - Othman AJ AD - Department of Public Health, Hawler Medical University, Erbil, Iraq. FAU - Rahman, Basoz Tariq AU - Rahman BT AUID- ORCID: 0009-0009-9472-3923 AD - Department of Public Health, Hawler Medical University, Erbil, Iraq. FAU - Mohamad, Soma M AU - Mohamad SM AD - Department of Public Health, Hawler Medical University, Erbil, Iraq. FAU - Haini, Clara Samad AU - Haini CS AD - Department of Public Health, Hawler Medical University, Erbil, Iraq. FAU - Fatah, Kaiwan Kareemkhan AU - Fatah KK AD - Department of Earth Science and Petroleum, College of Science, Salahaddin University, Erbil, Iraq. LA - eng PT - Journal Article DEP - 20260609 PL - England TA - Food Addit Contam Part B Surveill JT - Food additives & contaminants. Part B, Surveillance JID - 101317183 RN - 0 (Metals, Heavy) RN - 0 (Food Preservatives) RN - X045WJ989B (Sorbic Acid) RN - OJ245FE5EU (Sodium Benzoate) SB - IM MH - *Yogurt/analysis/economics MH - *Food Contamination/analysis MH - Humans MH - Iraq MH - *Metals, Heavy/analysis MH - *Food Preservatives/analysis MH - Chromatography, High Pressure Liquid MH - Limit of Detection MH - Sorbic Acid/analysis MH - Sodium Benzoate/analysis MH - Reproducibility of Results OTO - NOTNLM OT - Yoghurt OT - estimated daily intake OT - food safety OT - health risk OT - heavy metals OT - preservatives EDAT- 2026/06/09 12:49 MHDA- 2026/08/17 23:39 CRDT- 2026/06/09 08:03 PHST- 2026/08/17 23:39 [medline] PHST- 2026/06/09 12:49 [pubmed] PHST- 2026/06/09 08:03 [entrez] AID - 10.1080/19393210.2026.2679459 [doi] PST - ppublish SO - Food Addit Contam Part B Surveill. 2026 Sep;19(3):251-261. doi: 10.1080/19393210.2026.2679459. Epub 2026 Jun 9. PMID- 42261265 OWN - NLM STAT- MEDLINE DCOM- 20260908 LR - 20260909 IS - 1944-7922 (Electronic) IS - 1060-3271 (Linking) VI - 109 IP - 5 DP - 2026 Sep 1 TI - Analysis of Taurine in Infant Formula and Adult Nutritionals by HILIC-MS/MS, Collaborative Study, AOAC Official Method 2022.03:2026, Final Action. PG - 828-832 LID - 10.1093/jaoacint/qsag049 [doi] AB - BACKGROUND: Taurine is recognized as an essential growth factor and as being critical in the maintenance of functional tissue regulation. The fortification of taurine to infant formulas is necessary to provide sufficient nutrient to maintain serum levels equivalent to those of their counterparts fed on their mother's milk. OBJECTIVE: To evaluate method reproducibility of AOAC First Action Official MethodSM 2022.03 for compliance with the performance requirements described in AOAC Standard Method Performance Requirements (SMPR(R)) 2014.013. METHODS: Following protein precipitation with Carrez solutions, taurine is extracted and analyzed by hydrophilic interaction liquid chromatography-tandem mass spectrometry using multiple reaction monitoring. Stable isotope-labeled taurine internal standard is used for quantification to correct for losses in extraction and variations in ionization in the ion source. RESULTS: Thirteen laboratories participated in the analysis of blind-duplicate samples of seven nutritional products. After outliers were removed, precision as reproducibility was found to be within limits set in SMPR 2014.013 (/= 1 cardiovascular risk factor and 39% had >/= 2 risk factors. CONCLUSIONS: One in four early CCS lives with food insecurity. These children concurrently experience multiple cardiovascular risk factors and suboptimal dietary quality. Interventions targeting food and nutrition insecurity and other modifiable cardiovascular risk factors have potential to mitigate late effects and advance equity in survivorship outcomes. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Aziz-Bose, Rahela AU - Aziz-Bose R AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. rahela_aziz-bose@dfci.harvard.edu. AD - Harvard Medical School, Boston, MA, USA. rahela_aziz-bose@dfci.harvard.edu. AD - Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. rahela_aziz-bose@dfci.harvard.edu. FAU - Paul, Morgan A AU - Paul MA AD - Department of Data Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. FAU - Lokko, Lucille AU - Lokko L AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. FAU - Jones, Emily AU - Jones E AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. FAU - Meng, Julie AU - Meng J AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. FAU - Fry, Callie AU - Fry C AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. AD - Harvard Medical School, Boston, MA, USA. FAU - Kelly, Colleen A AU - Kelly CA AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. AD - Harvard Medical School, Boston, MA, USA. AD - Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. FAU - Umaretiya, Puja J AU - Umaretiya PJ AD - Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. FAU - Duhaney, Leanne AU - Duhaney L AD - Division of Cardiology, Boston Children's Hospital, Boston, MA, USA. FAU - Kenney, Lisa B AU - Kenney LB AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. AD - Harvard Medical School, Boston, MA, USA. AD - Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. FAU - Zhang, Fang Fang AU - Zhang FF AD - Friedman School of Nutrition and Public Policy, Tufts University, Boston, MA, USA. FAU - Bona, Kira AU - Bona K AD - Dana-Farber/Boston Children's Cancer and Blood Disorders Center, Boston, MA, USA. AD - Harvard Medical School, Boston, MA, USA. AD - Division of Population Sciences, Dana-Farber Cancer Institute, Boston, MA, USA. LA - eng GR - T32 CA136432/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20260609 PL - Germany TA - Support Care Cancer JT - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer JID - 9302957 SB - IM MH - Humans MH - *Food Insecurity MH - Male MH - Female MH - Child MH - Heart Disease Risk Factors MH - *Cancer Survivors/statistics & numerical data MH - *Diet/standards/statistics & numerical data MH - *Cardiovascular Diseases/epidemiology/etiology MH - Child, Preschool MH - *Neoplasms/therapy MH - Infant MH - Cohort Studies MH - Adolescent MH - Risk Factors MH - Prevalence PMC - PMC13384394 MID - NIHMS2190528 OTO - NOTNLM OT - Cardiovascular disease OT - Childhood cancer survivors OT - Food insecurity OT - Nutrition insecurity OT - Social determinants of health COIS- Declarations. Ethics Approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Institutional Review Board of Dana-Farber Cancer Institute (protocol DFCI 23-398). Consent to participate: Informed consent was obtained from all study participants, with a waiver of written documentation of informed consent. Consent to publish: N/A Role of the Funder: The funders did not play a role in the design of the study; the collection, analysis, and interpretation of the data; the writing of the manuscript; or the decision to submit the manuscript for publication. Competing interests: The authors declare no competing interests. EDAT- 2026/06/09 00:34 MHDA- 2026/06/13 06:39 PMCR- 2027/06/09 CRDT- 2026/06/08 23:33 PHST- 2026/03/27 00:00 [received] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/06/13 06:39 [medline] PHST- 2026/06/09 00:34 [pubmed] PHST- 2026/06/08 23:33 [entrez] PHST- 2027/06/09 00:00 [pmc-release] AID - 10.1007/s00520-026-10870-0 [pii] AID - 10.1007/s00520-026-10870-0 [doi] PST - epublish SO - Support Care Cancer. 2026 Jun 9;34(7):631. doi: 10.1007/s00520-026-10870-0. PMID- 42259585 OWN - NLM STAT- MEDLINE DCOM- 20260609 LR - 20260624 IS - 1756-1833 (Electronic) IS - 0959-8138 (Linking) VI - 393 DP - 2026 Jun 8 TI - Advances in the management of ADHD in children and adolescents. PG - e082507 LID - 10.1136/bmj-2024-082507 [doi] AB - This review synthesizes evidence on managing attention deficit/hyperactivity disorder (ADHD) in children and adolescents, focusing on studies published between 2019 and 2025. Recent research supports a dimensional, pleiotropic model of ADHD characterized by heterogeneity, developmental fluctuation, and frequent comorbidity. ADHD is a chronic, fluctuating condition, underscoring the need for sustained and individualized care. Diagnostic strategies favor semi-structured interviews over rating scales, with neuroimaging or biological tests offering limited diagnostic utility. Neuropsychological testing situates symptoms within broader cognitive developmental profiles. Psychosocial interventions-particularly behavioral parent training, school focused interventions, and cognitive behavioral therapy-produce small but meaningful improvements in functioning, with outcomes strongly shaped by rater, expectancy, and context. Lifestyle interventions targeting physical activity and sleep show modest adjunctive benefits. Cognitive training does not generalize beyond trained tasks, and effects on neurofeedback are predominantly non-specific and contextual. Digital tools are expanding, but few are rigorously validated. Pharmacological treatment remains central, with stimulants showing robust short term efficacy and non-stimulants providing effective second line options. Advances in titration strategies, formulation design, and pharmacogenetics support movement towards precision oriented and personalized prescribing. Overall, the evidence supports a multimodal, pragmatic approach to care aligned with current international guidelines. CI - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions. FAU - Robaey, Philippe AU - Robaey P AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada probaey@cheo.on.ca. AD - Department of Psychiatry, University of Ottawa, Ottawa, ON, Canada. FAU - Rogers, Maria A AU - Rogers MA AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. AD - Department of Psychology, Carleton University, Ottawa, ON, Canada. FAU - Schachar, Russell J AU - Schachar RJ AD - Department of Psychiatry, University of Toronto, Toronto, ON, Canada. AD - Department of Psychiatry, The Hospital for Sick Children, Toronto, ON, Canada. LA - eng PT - Journal Article PT - Review DEP - 20260608 PL - England TA - BMJ JT - BMJ (Clinical research ed.) JID - 8900488 RN - 0 (Central Nervous System Stimulants) SB - IM MH - Adolescent MH - Child MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/diagnosis/therapy MH - Central Nervous System Stimulants/therapeutic use MH - Cognitive Behavioral Therapy/methods MH - Cognitive Training COIS- Competing interests: We have read and understood the BMJ policy on declaration of interests and declare the following interests: none. EDAT- 2026/06/09 00:34 MHDA- 2026/06/10 06:53 CRDT- 2026/06/08 20:52 PHST- 2026/06/10 06:53 [medline] PHST- 2026/06/09 00:34 [pubmed] PHST- 2026/06/08 20:52 [entrez] AID - 10.1136/bmj-2024-082507 [doi] PST - epublish SO - BMJ. 2026 Jun 8;393:e082507. doi: 10.1136/bmj-2024-082507. PMID- 42259520 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2190-6009 (Electronic) IS - 2190-5991 (Print) IS - 2190-5991 (Linking) VI - 17 IP - 3 DP - 2026 Jun TI - Diagnostic Utility of Muscle Ultrasound for Sarcopenia in Prader-Willi Syndrome: A Cross-Sectional Study. PG - e70326 LID - 10.1002/jcsm.70326 [doi] LID - e70326 AB - BACKGROUND: Prader-Willi syndrome (PWS) is characterized by sarcopenic obesity; however, validated screening tools for muscle mass in clinical settings are lacking. This study aimed to evaluate the diagnostic utility of muscle ultrasound (US) for detecting low muscle mass in individuals with PWS. METHODS: This observational, cross-sectional study recruited 48 individuals with genetically confirmed PWS (International Classification of Diseases, 10th Revision Code Q87.1) from a specialized clinic (October 2022-June 2024). Appendicular skeletal muscle index (ASMI) via dual-energy x-ray absorptiometry (DXA) served as the primary outcome. Sarcopenia was defined based on Asian Working Group for Sarcopenia (AWGS) 2019 criteria. US predictors included muscle thickness (MT) of the rectus femoris (RF), vastus lateralis and gastrocnemius medialis (GM); pennation angle; and RF cross-sectional area (CSA). Analysis included Spearman's correlation (rho), multivariable linear regression (B) and receiver operating characteristic (ROC) curves. RESULTS: The cohort (n = 48; 47.9% women; median age 19.5 years, interquartile range [IQR] 12.3-26.8) had a 100% prevalence of obesity (median BMI 27.1 kg/m(2), IQR 22.2-31.4). All participants (100%) had a history of growth hormone treatment; 62.5% exhibited the deletion subtype. Low muscle mass was observed in 60.4% (n = 29), confirmed sarcopenia in 52.1% (n = 25) and severe sarcopenia (including low physical performance) in 20.8% (n = 10) participants. GM MT showed the strongest correlation with ASMI (rho = 0.689, p < 0.001, 95% confidence interval [CI] 0.50-0.81), followed by RF CSA (rho = 0.587, p < 0.001). Multivariable regression identified GM MT as a significant independent predictor of ASMI (B = 0.957, p = 0.011) after adjusting for BMI (B = 0.128, p < 0.001), age (B = 0.020, p = 0.044) and sex (B = -0.376, p = 0.029; R(2) = 0.67). ROC analysis for detecting low muscle mass yielded an area under the curve for GM MT of 0.759 (95% CI 0.616-0.901, p = 0.003), with an optimal cut-off of 1.69 cm (sensitivity 86.2%, specificity 63.2%). CONCLUSIONS: Sarcopenia affects 52.1% of patients with PWS, with 20.8% meeting criteria for severe sarcopenia. Ultrasound of the gastrocnemius medialis is a valid, radiation-free predictor of skeletal muscle mass and serves as a practical diagnostic tool for sarcopenic obesity in PWS. CI - (c) 2026 The Author(s). Journal of Cachexia, Sarcopenia and Muscle published by Wiley Periodicals LLC. FAU - Yu, Luo-Hua AU - Yu LH AD - Department of Physical Medicine and Rehabilitation, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. FAU - Wu, Hsin-Chi AU - Wu HC AD - Department of Physical Medicine and Rehabilitation, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. AD - Department of Medicine, Tzu Chi University, Hualien, Taiwan. FAU - Tzeng, I-Shiang AU - Tzeng IS AD - Department of Research, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. FAU - Luo, Yan-Ting AU - Luo YT AD - Department of Physical Medicine and Rehabilitation, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. FAU - Tsai, Li-Ping AU - Tsai LP AD - Department of Pediatrics, Heping Fuyou Branch, Taipei City Hospital, Taipei, Taiwan. AD - Department of Molecular Biology and Human Genetics, College of Medicine, Tzu Chi University, Hualien, Taiwan. FAU - Chiu, Valeria AU - Chiu V AUID- ORCID: 0000-0002-5170-2964 AD - Department of Physical Medicine and Rehabilitation, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, New Taipei City, Taiwan. AD - Department of Medicine, Tzu Chi University, Hualien, Taiwan. LA - eng GR - TCRD-TPE-112-28/Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation/ GR - TCRD-TPE-112-RT-5/Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation/ PT - Journal Article PT - Observational Study PL - Germany TA - J Cachexia Sarcopenia Muscle JT - Journal of cachexia, sarcopenia and muscle JID - 101552883 SB - IM MH - Humans MH - *Prader-Willi Syndrome/complications MH - *Sarcopenia/etiology/diagnosis/diagnostic imaging MH - Female MH - Cross-Sectional Studies MH - Ultrasonography/methods MH - Male MH - *Muscle, Skeletal/diagnostic imaging MH - Adult MH - Adolescent MH - Young Adult MH - Child PMC - PMC13246224 OTO - NOTNLM OT - Prader-Willi syndrome OT - body composition OT - sarcopenia OT - ultrasonography COIS- The authors declare no conflicts of interest. EDAT- 2026/06/09 00:33 MHDA- 2026/06/12 04:10 PMCR- 2026/06/08 CRDT- 2026/06/08 20:13 PHST- 2026/05/02 00:00 [revised] PHST- 2024/06/20 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/06/12 04:10 [medline] PHST- 2026/06/09 00:33 [pubmed] PHST- 2026/06/08 20:13 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - JCSM70326 [pii] AID - 10.1002/jcsm.70326 [doi] PST - ppublish SO - J Cachexia Sarcopenia Muscle. 2026 Jun;17(3):e70326. doi: 10.1002/jcsm.70326. PMID- 42259208 OWN - NLM STAT- MEDLINE DCOM- 20260724 LR - 20260724 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 268 DP - 2026 Aug TI - A study on the impact of AI health monitoring devices on exercise persistence among physical education students. PG - 107176 LID - S0001-6918(26)00977-7 [pii] LID - 10.1016/j.actpsy.2026.107176 [doi] AB - OBJECTIVE: This study investigates how the use motivations of AI health monitoring devices influence exercise persistence in physical education students, focusing on the mediating role of exercise enjoyment and exercise commitment. METHOD: The researchers conducted a survey among 764 Chinese university students using the Motivation for Use Scale, the Physical Activity Enjoyment Scale, the Exercise Commitment Scale, and the Physical Exercise Adherence Scale. The proposed chain mediation model was subsequently tested and validated. RESULTS: (1) The use motivations of AI health monitoring devices show a significant positive association with exercise persistence. (2) Exercise enjoyment and exercise commitment demonstrate both independent and sequential mediation effects in the model, with the mediation effect of exercise commitment being relatively stronger. CONCLUSION: The study identifies important associations among use motivations, exercise enjoyment, exercise commitment, and exercise persistence, offering useful insights for future practices and research aimed at supporting exercise-related behaviors among physical education students. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Wang, Chunxiao AU - Wang C AD - College of Sports Science and Health, Harbin Sport University, Harbin, Heilongjiang, 150008, China. FAU - Meng, Nijia AU - Meng N AD - College of Sports Science and Health, Harbin Sport University, Harbin, Heilongjiang, 150008, China. FAU - Han, Peng AU - Han P AD - College of Sports Science and Health, Harbin Sport University, Harbin, Heilongjiang, 150008, China. FAU - Liu, Chunhua AU - Liu C AD - Center of Training and Competition, Harbin Sport University, Harbin, Heilongjiang, 150008, China. Electronic address: hrbipe2019@163.com. LA - eng PT - Journal Article DEP - 20260608 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM MH - Humans MH - Female MH - *Students/psychology MH - *Exercise/psychology MH - *Motivation MH - Male MH - *Physical Education and Training MH - Young Adult MH - Universities MH - Adult MH - Digital Health MH - Adolescent OTO - NOTNLM OT - Exercise commitment OT - Exercise enjoyment OT - Exercise persistence OT - Physical education students OT - The use motivations of AI health monitoring devices COIS- Declaration of competing interest The authors have no competing interests to declare that are relevant to the content of this article. EDAT- 2026/06/09 00:34 MHDA- 2026/07/24 06:35 CRDT- 2026/06/08 18:10 PHST- 2025/07/23 00:00 [received] PHST- 2026/05/26 00:00 [revised] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/07/24 06:35 [medline] PHST- 2026/06/09 00:34 [pubmed] PHST- 2026/06/08 18:10 [entrez] AID - S0001-6918(26)00977-7 [pii] AID - 10.1016/j.actpsy.2026.107176 [doi] PST - ppublish SO - Acta Psychol (Amst). 2026 Aug;268:107176. doi: 10.1016/j.actpsy.2026.107176. Epub 2026 Jun 8. PMID- 42259017 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1096-7206 (Electronic) IS - 1096-7192 (Linking) VI - 148 IP - 4 DP - 2026 Aug TI - Analysis of clinical pedigree characteristics in Chinese patients with ataxia with vitamin E deficiency. PG - 110167 LID - S1096-7192(26)00450-6 [pii] LID - 10.1016/j.ymgme.2026.110167 [doi] AB - The clinical and genetic features of ataxia with isolated vitamin E deficiency (AVED) patients in Chinese are remain not well understood. We enrolled 120 unrelated probands with clinically suspected autosomal recessive cerebellar ataxia (ARCA) at the Department of Neurology, China-Japan Friendship Hospital between 2014 and 2024. all probands underwent Whole-exome sequencing (WES), with candidate variants validated by Sanger sequencing and family cosegregation analysis. In silico pathogenicity analysis, including protein structure homology modeling and multispecies conservation analysis, was performed for novel variants. Plasma vitamin E levels were measured using high-performance liquid chromatography with diode array detection(HPLC-DAD). We identified 4 probands with biallelic TTPA variants, accounting for 3.33% of the ARCA cohort. Three probands were from consanguineous families, and 1 was from non- consanguineous family. The median age at onset was 15years (range 14-23years), with gait instability/ataxia as the universal initial symptom. Core clinical features included cerebellar ataxia (4/4), dysarthria (4/4), areflexia (2/4), scoliosis (4/4), foot deformity (3/4), and head titubation (3/4). Brain MRI revealed cerebellar atrophy in 3 patients, and all had markedly reduced serum vitamin E levels. We identified 2 novel missense variants (c.265C>A(p.P89T) and c.790A>G(p.M264V)). All patients received high-dose vitamin E supplementation, with 3/4 improved ataxia symptoms at 2-years follow-up. Our findings expand the clinical and genetic spectrum of AVED in China and support early evaluation of plasma vitamin E status and TTPA variants in patients with unexplained sporadic or recessive ataxia, as well as proactive screening of siblings and other at-risk relatives, even before symptom onset. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Lv, Pu AU - Lv P AD - Department of Geriatric, China-Japan Friendship Hospital, Beijing 100029, China. FAU - Liu, Lu AU - Liu L AD - Department of Geriatric, China-Japan Friendship Hospital, Beijing 100029, China. FAU - Hao, Ying AU - Hao Y AD - Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 10029, China. FAU - Zhou, Zhi AU - Zhou Z AD - Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, China. FAU - Chen, Xin AU - Chen X AD - Department of Geriatric, China-Japan Friendship Hospital, Beijing 100029, China. FAU - Zhang, Linwei AU - Zhang L AD - Department of Neurology, China-Japan Friendship Hospital, Beijing 100029, China. Electronic address: zhanglw999@hotmail.com. LA - eng PT - Journal Article DEP - 20260603 PL - United States TA - Mol Genet Metab JT - Molecular genetics and metabolism JID - 9805456 RN - 0 (alpha-tocopherol transfer protein) RN - 1406-18-4 (Vitamin E) RN - 0 (Carrier Proteins) RN - Ataxia with vitamin E deficiency RN - Chinese people SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - *Cerebellar Ataxia/genetics/pathology MH - China MH - Exome Sequencing MH - Mutation MH - Pedigree MH - Vitamin E/blood MH - *Vitamin E Deficiency/genetics/pathology/blood MH - East Asian People/genetics MH - Ataxia MH - Carrier Proteins OTO - NOTNLM OT - Cerebellar ataxia OT - Cerebellar atrophy OT - Mutation OT - Phenotype OT - TTPA gene COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/09 00:34 MHDA- 2026/07/16 12:40 CRDT- 2026/06/08 18:04 PHST- 2026/03/05 00:00 [received] PHST- 2026/05/23 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/07/16 12:40 [medline] PHST- 2026/06/09 00:34 [pubmed] PHST- 2026/06/08 18:04 [entrez] AID - S1096-7192(26)00450-6 [pii] AID - 10.1016/j.ymgme.2026.110167 [doi] PST - ppublish SO - Mol Genet Metab. 2026 Aug;148(4):110167. doi: 10.1016/j.ymgme.2026.110167. Epub 2026 Jun 3. PMID- 42258993 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260803 IS - 1532-2653 (Electronic) IS - 0967-5868 (Linking) VI - 152 DP - 2026 Oct TI - Quantitative hippocampal subfield volumetry using AID-HS in mesial temporal lobe epilepsy: correlation with histopathology. PG - 112129 LID - S0967-5868(26)00280-8 [pii] LID - 10.1016/j.jocn.2026.112129 [doi] AB - PURPOSE: To evaluate the diagnostic accuracy of the AID-HS pipeline in characterizing hippocampal subfield volumetric patterns and distinguishing HS subtypes, using histopathology as the reference standard in mesial temporal lobe epilepsy (mTLE). METHODS: Thirty patients with surgically treated mTLE underwent 3.0 T MRI. Volumetric subfield analysis was performed using the automated AID-HS tool.Hippocampal subfield volumes were compared between typical HS type 1 and atypical HS, including HS types 2 and 3, with validation against the 2013 ILAE histopathological criteria. Subfields of the sclerotic hippocampus were categorized as volume-reduced or volume-preserved based on the asymmetry index. RESULTS: HS type 1 was predominant, accounting for 83.3% of cases. In typical HS type 1, volume reduction in CA2 and CA3 was more frequently observed than in atypical HS on volumetric comparison, and MRI-detected volume reduction in CA2, CA3, and CA4 was significantly associated with histopathological sclerosis (p < 0.01) . Diagnostic accuracy showed fair to good classification performance for distinguishing HS subtypes, with AUC values ranging from 0.73 to 0.83. The CA3 subfield achieved the highest accuracy, with an AUC of 0.83 and 100% sensitivity. CONCLUSION: The AID-HS pipeline may provide quantitative support for subtype-oriented evaluation of HS. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Hung, Nguyen Duy AU - Hung ND AD - Department of Radiology, Hanoi Medical University, Ha Noi, Viet Nam; Department of Radiology, Viet Duc Hospital, Ha Noi, Viet Nam. Electronic address: duyhung@hmu.edu.vn. FAU - Minh Chau, Nguyen Thu AU - Minh Chau NT AD - Department of Radiology, Hanoi Medical University, Ha Noi, Viet Nam. Electronic address: thuminhchou@gmail.com. FAU - Van, Tran Dinh AU - Van TD AD - Department of Neurosurgery 1, Viet Duc Hospital, Ha Noi, Viet Nam. Electronic address: tranvanpttk@gmail.com. FAU - Ngan, Vuong Kim AU - Ngan VK AD - Department of Radiology, Hanoi Medical University, Ha Noi, Viet Nam; Department of Radiology, Vinmec Times City International Hospital, Vinmec Healthcare System, Ha Noi, Viet Nam. Electronic address: drkimngan.rad@gmail.com. LA - eng PT - Journal Article DEP - 20260608 PL - Scotland TA - J Clin Neurosci JT - Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia JID - 9433352 SB - IM MH - Humans MH - *Epilepsy, Temporal Lobe/pathology/diagnostic imaging/surgery MH - Female MH - Male MH - *Hippocampus/pathology/diagnostic imaging/surgery MH - *Magnetic Resonance Imaging/methods MH - Adult MH - Young Adult MH - Hippocampal Sclerosis/pathology MH - Middle Aged MH - Adolescent MH - Organ Size MH - Image Processing, Computer-Assisted/methods OTO - NOTNLM OT - Hippocampal sclerosis OT - Hippocampal subfields OT - Histopathology correlation OT - Magnetic resonance imaging OT - Mesial temporal lobe epilepsy OT - Quantitative MRI COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/08 19:43 MHDA- 2026/08/04 00:35 CRDT- 2026/06/08 18:03 PHST- 2026/02/20 00:00 [received] PHST- 2026/05/27 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/08/04 00:35 [medline] PHST- 2026/06/08 19:43 [pubmed] PHST- 2026/06/08 18:03 [entrez] AID - S0967-5868(26)00280-8 [pii] AID - 10.1016/j.jocn.2026.112129 [doi] PST - ppublish SO - J Clin Neurosci. 2026 Oct;152:112129. doi: 10.1016/j.jocn.2026.112129. Epub 2026 Jun 8. PMID- 42258969 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260915 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 90 DP - 2026 Sep-Oct TI - Development and initial validation of the nursing practices, perceptions and barriers questionnaire for childhood obesity: A cross-sectional observational study. PG - 77-86 LID - S0882-5963(26)00252-6 [pii] LID - 10.1016/j.pedn.2026.05.045 [doi] AB - AIM: To develop and preliminarily validate a questionnaire assessing primary care nurses' practices, perceptions, and perceived barriers in managing childhood obesity. DESIGN: Sequential exploratory study conducted in three phases: item development, content validation, and a cross-sectional observational study with an initial psychometric validation. METHODS: Items were generated through a literature review, focus groups, and adaptation of an existing adult obesity instrument. A panel of six experts assessed content validity, clarity, coherence, and item adequacy. The final version 39-item questionnaire was distributed online to primary care nurses in Madrid, Spain; 253 complete responses were analyzed. Descriptive statistics were calculated. A preliminary Exploratory Factor Analysis was conducted on selected items. RESULTS: The overall content validity index was 0.96. The final instrument identified three areas: training and experience, practices and barriers, and knowledge of childhood obesity. Factor analyses supported coherent underlying dimensions for selected items, with acceptable internal consistency. Nurses reported positive attitudes toward addressing pediatric obesity but identified barriers such as limited consultation time, low treatment adherence, and intervention complexity. CONCLUSION: The NPPBQ-CO is a structured instrument with initial evidence of content validity, preliminary psychometric support and acceptable internal consistency. Further validation is warranted. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Miguel-Atanes, Cristina AU - Miguel-Atanes C AD - Department of Biological and Health Psychology, Faculty of Psychology, Autonomous University of Madrid, Spain. Electronic address: cristina.miguelatanes@gmail.com. FAU - Gomez-Lobo, Andrea Gil AU - Gomez-Lobo AG AD - Department of Biological and Health Psychology, Faculty of Psychology, Autonomous University of Madrid, Spain. Electronic address: andrea.gilg@uam.es. FAU - Solar, Maria AU - Solar M AD - TEA EDICIONES SAU, Madrid, Spain. FAU - Sepulveda, Ana Rosa AU - Sepulveda AR AD - Department of Biological and Health Psychology, Faculty of Psychology, Autonomous University of Madrid, Spain. Electronic address: anarosa.sepulveda@uam.es. LA - eng PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20260608 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Female MH - *Pediatric Obesity/nursing/diagnosis MH - Psychometrics MH - Reproducibility of Results MH - Child MH - Spain MH - Male MH - *Pediatric Nursing MH - Adult MH - Attitude of Health Personnel MH - *Primary Care Nursing OTO - NOTNLM OT - Nursing care OT - Nursing, practical OT - Pediatric obesity OT - Primary health care OT - Surveys and questionnaires COIS- Declaration of competing interest There is no conflict of interest regarding the publication of this article. EDAT- 2026/06/08 19:42 MHDA- 2026/09/07 23:34 CRDT- 2026/06/08 18:02 PHST- 2025/11/25 00:00 [received] PHST- 2026/05/28 00:00 [revised] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/09/07 23:34 [medline] PHST- 2026/06/08 19:42 [pubmed] PHST- 2026/06/08 18:02 [entrez] AID - S0882-5963(26)00252-6 [pii] AID - 10.1016/j.pedn.2026.05.045 [doi] PST - ppublish SO - J Pediatr Nurs. 2026 Sep-Oct;90:77-86. doi: 10.1016/j.pedn.2026.05.045. Epub 2026 Jun 8. PMID- 42258963 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260806 IS - 1878-5506 (Electronic) IS - 1389-9457 (Linking) VI - 146 DP - 2026 Oct TI - Performance of three consumer sleep-tracking devices compared with Actigraphy and Polysomnography. PG - 109059 LID - S1389-9457(26)00298-4 [pii] LID - 10.1016/j.sleep.2026.109059 [doi] AB - PURPOSE: To compare the performance of three consumer wearables (Apple Watch Series 7, Fitbit Charge 5, Polar Vantage M2) against home polysomnography (PSG) and actigraphy using complementary metrics of accuracy, agreement, and reliability. METHODS: This prospective observational study was conducted at King Abdulaziz University Hospital on healthy adults aged 18-45 years. Participants were allocated to one wearable (Fitbit n = 20; Apple Watch n = 19; Polar n = 15). PSG performed during a home visit and a research-grade actigraph was worn concurrently (7 days) for ambulatory reference. Primary outcomes were wearable-PSG differences for time in bed (TIB), total sleep time (TST), and stage durations (Rapid Eye Movement (REM), light, deep). Agreement was assessed using intraclass correlation coefficients (ICCs) and Bland-Altman analyses. RESULTS: Across devices, agreement with PSG was generally weak with wide LOA. Compared with PSG, Fitbit overestimated light sleep (+57.7 +/- 80.5 min, P = .009). Apple Watch underestimated light sleep (-73.8 +/- 61.6 min, P < .001) and overestimated REM (+30.3 +/- 36.3 min, P = .003). Polar showed a positive REM bias (+32.3 +/- 43.6 min, P = .026) without significant differences for other parameters. Overall ranking favored Apple Watch, followed by Fitbit and Polar. CONCLUSIONS: Apple Watch Series 7, Fitbit Charge 5, and Polar Vantage M2 demonstrated parameter-specific bias and limited agreement with PSG and actigraphy. These devices may be appropriate for longitudinal self-monitoring rather than clinical-grade assessment of sleep architecture. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Alhejaili, Faris AU - Alhejaili F AD - Respiratory Section, Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Sleep Medicine and Research Center, Sleep Medicine Research Group, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. Electronic address: Falhejaili@kau.edu.sa. FAU - Alshumrani, Ranya AU - Alshumrani R AD - Sleep Medicine and Research Center, Sleep Medicine Research Group, King Abdulaziz University Hospital, Jeddah, Saudi Arabia; Respiratory Section, Pediatrics Department, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Alamoudi, Wail AU - Alamoudi W AD - Sleep Medicine and Research Center, Sleep Medicine Research Group, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. FAU - Wali, Siraj AU - Wali S AD - Respiratory Section, Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Sleep Medicine and Research Center, Sleep Medicine Research Group, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. FAU - Bamagoos, Ahmad AU - Bamagoos A AD - Sleep Medicine and Research Center, Sleep Medicine Research Group, King Abdulaziz University Hospital, Jeddah, Saudi Arabia; Physiology Department, Faculty of Medicine in Rabigh, King Abdulaziz University, Rabigh, Saudi Arabia. FAU - Wazira, Lamar AU - Wazira L AD - Internal Medicine Resident, Dr. Soliman Fakeeh Hospital, Jeddah, SA, Saudi Arabia. FAU - Ahmad, Hanin AU - Ahmad H AD - Obstetrics and Gynecology Resident, Dr. Soliman Fakeeh Hospital, Jeddah, SA, Saudi Arabia. FAU - Azab, Ehda AU - Azab E AD - Medical Intern, Faculty of Medicine, King Abdulaziz University, Jeddah, SA, Saudi Arabia. FAU - Banjer, Hanin AU - Banjer H AD - ENT Resident, Ministry of Health, Jeddah, SA, Saudi Arabia. FAU - Alzahrani, Asayel AU - Alzahrani A AD - Diagnostic Radiology Resident, Ministry of National Guard Health Affairs, Jeddah, SA, Saudi Arabia. FAU - Baghdadi, Ebtihal AU - Baghdadi E AD - General Practitioner, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Gozal, David AU - Gozal D AD - Departments of Pediatrics, Dentistry and Oral and Maxillofacial Surgery, and Biomedical Sciences, and Office of the Dean, Joan C. Edwards School of Medicine, Marshall University, Huntington, WV, USA. LA - eng PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20260604 PL - Netherlands TA - Sleep Med JT - Sleep medicine JID - 100898759 SB - IM MH - Humans MH - *Polysomnography/instrumentation MH - *Actigraphy/instrumentation MH - Adult MH - Female MH - Male MH - Prospective Studies MH - Reproducibility of Results MH - Sleep Duration MH - Middle Aged MH - *Wearable Electronic Devices MH - Young Adult MH - Adolescent MH - *Sleep/physiology OTO - NOTNLM OT - Actigraphy OT - Activity trackers OT - Bio-sensing techniques OT - Polysomnography OT - Sleep stages OT - Wearable electronic devices COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. D.G. is supported by National Institutes of Health grants. EDAT- 2026/06/08 19:42 MHDA- 2026/07/12 00:54 CRDT- 2026/06/08 18:02 PHST- 2026/03/02 00:00 [received] PHST- 2026/05/17 00:00 [revised] PHST- 2026/06/03 00:00 [accepted] PHST- 2026/07/12 00:54 [medline] PHST- 2026/06/08 19:42 [pubmed] PHST- 2026/06/08 18:02 [entrez] AID - S1389-9457(26)00298-4 [pii] AID - 10.1016/j.sleep.2026.109059 [doi] PST - ppublish SO - Sleep Med. 2026 Oct;146:109059. doi: 10.1016/j.sleep.2026.109059. Epub 2026 Jun 4. PMID- 42258527 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 6 DP - 2026 TI - Spurious effects in random-intercept cross-lagged panel models: Results from simulations and reanalyses of data on self-esteem and problematic eating behaviors used by Beckers et al. (2023). PG - e0351302 LID - 10.1371/journal.pone.0351302 [doi] LID - e0351302 AB - The random-intercept cross-lagged panel model (RI-CLPM) is an extension of the traditional cross-lagged panel model. The RI-CPLM specifically addresses prospective effects within individuals. In the present simulations, we found that the RI-CLPM is susceptible to spurious findings when observed scores on the two variables are affected by common auto-correlated state factors. In reanalyses of empirical data, we found contradictory decreasing, increasing, and null prospective effects between within-individual levels of self-esteem and problematic eating behaviors among Dutch teenagers (N = 1856). These contradictory findings indicated that previously reported prospective effects may have been statistical artifacts. Caution is advised when using the RI-CLPM, as it may produce misleading results. Researchers are recommended to validate findings using alternative analyses, e.g., by examining person-mean centered scores. CI - Copyright: (c) 2026 Sorjonen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Sorjonen, Kimmo AU - Sorjonen K AUID- ORCID: 0000-0001-9930-057X AD - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. FAU - Nilsonne, Gustav AU - Nilsonne G AD - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. AD - Department of Psychology, Stockholm University, Stockholm, Sweden. FAU - Ghaderi, Ata AU - Ghaderi A AD - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. FAU - Melin, Bo AU - Melin B AD - Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. LA - eng PT - Journal Article DEP - 20260608 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Self Concept MH - Adolescent MH - *Feeding Behavior/psychology MH - Female MH - *Feeding and Eating Disorders/psychology PMC - PMC13245769 COIS- The authors have declared that no competing interests exist. EDAT- 2026/06/08 19:39 MHDA- 2026/06/15 11:30 PMCR- 2026/06/08 CRDT- 2026/06/08 13:44 PHST- 2025/08/04 00:00 [received] PHST- 2026/05/22 00:00 [accepted] PHST- 2026/06/15 11:30 [medline] PHST- 2026/06/08 19:39 [pubmed] PHST- 2026/06/08 13:44 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - PONE-D-25-39381 [pii] AID - 10.1371/journal.pone.0351302 [doi] PST - epublish SO - PLoS One. 2026 Jun 8;21(6):e0351302. doi: 10.1371/journal.pone.0351302. eCollection 2026. PMID- 42258366 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260903 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Jun 8 TI - Social Partner Effects on Type 2 Diabetes Prevention, Management, and Spillover Health Outcomes: Single-Arm Pre-Post Pilot Intervention. PG - e82438 LID - 10.2196/82438 [doi] LID - e82438 AB - BACKGROUND: South Asian Americans are at high risk of prediabetes and type 2 diabetes mellitus (T2DM). South Asian populations are typically close-knit communities, with support networks that could be leveraged in lifestyle interventions. OBJECTIVE: This study was a single-arm, pre-post pilot study to evaluate the feasibility and efficacy of a culturally tailored telehealth intervention for South Asian adults with prediabetes or T2DM and their social partners (trusted household members) who agreed to complete preintervention and postintervention surveys. METHODS: Participants attended 5-hour-long health education sessions delivered in English and Bengali. Participant outcomes included pre-post changes in hemoglobin A1c (HbA1c), BMI, blood pressure (BP), self-reported minutes of physical activity, and dietary choices at baseline and at the 6-month follow-up. For social partners, outcomes included pre-post survey changes in physical activity and dietary choices. We used Pearson chi-square tests and paired 2-tailed t tests to compare baseline measures with postintervention outcomes. RESULTS: This pilot study included 54 participants and 106 social partners in Atlanta, Georgia, between March 2021 and November 2023. All participants were Bangladeshi and spoke native Bengali. Social partners were most commonly participants' children (39/106, 36.8%) or spouses (34/106, 32.1%). The participant baseline HbA1c level was 7.5% (SD 1.48%), which decreased by -0.83% (95% CI 0.42%-1.30%; P<.001). Participants also improved systolic BP by -5.8 mm Hg (95% CI 0.196-11.37; P=.04) with no change in diastolic BP (-0.451 mm Hg, 95% CI -1.49 to 2.39; P=.60) or BMI (-0.642 kg/m2, 95% CI -1.87 to 0.59; P=.17). Compared with baseline, 39% more participants exercised at least 150 minutes weekly (P<.001), but there was no difference in self-reported fruit and vegetable intake. However, the social partners increased fruit and vegetable intake (P=.02), decreased soda intake (P<.001), and increased daily moderate exercise (P=.003). CONCLUSIONS: Including social partners in T2DM prevention and management is feasible and potentially beneficial, but comparative studies are needed to determine the incremental effects of social partners' participation vs individual-focused lifestyle interventions. CI - (c) Natalie B Connell, Sakila Nasrin, Zohra Amin, Nazneen Akhet, Mohammed K Ali, K M Venkat Narayan, Megha Shah. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Connell, Natalie B AU - Connell NB AUID- ORCID: 0009-0002-6834-0143 AD - Department of Family and Preventive Medicine, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA, 30306, United States, 1 1-404-727-4018. FAU - Nasrin, Sakila AU - Nasrin S AUID- ORCID: 0009-0006-6127-0903 AD - Department of Family and Preventive Medicine, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA, 30306, United States, 1 1-404-727-4018. FAU - Amin, Zohra AU - Amin Z AUID- ORCID: 0009-0003-2246-5378 AD - Department of Family and Preventive Medicine, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA, 30306, United States, 1 1-404-727-4018. FAU - Akhter, Nazneen AU - Akhter N AUID- ORCID: 0009-0008-2871-0609 AD - Department of Family and Preventive Medicine, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA, 30306, United States, 1 1-404-727-4018. FAU - Ali, Mohammed K AU - Ali MK AUID- ORCID: 0000-0001-7266-2503 AD - Emory University, Emory Global Diabetes Research Center, Woodruff Health Sciences Center, Atlanta, GA, United States. FAU - Narayan, K M Venkat AU - Narayan KMV AUID- ORCID: 0000-0001-8621-5405 AD - Emory University, Emory Global Diabetes Research Center, Woodruff Health Sciences Center, Atlanta, GA, United States. FAU - Shah, Megha AU - Shah M AUID- ORCID: 0000-0002-6722-7846 AD - Department of Family and Preventive Medicine, Emory University School of Medicine, 100 Woodruff Circle, Atlanta, GA, 30306, United States, 1 1-404-727-4018. LA - eng SI - ClinicalTrials.gov/NCT05275231 GR - K23 MD015088/MD/NIMHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260608 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 RN - 0 (Glycated Hemoglobin) SB - IM MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - *Diabetes Mellitus, Type 2/prevention & control/therapy/ethnology/psychology MH - Exercise MH - Glycated Hemoglobin/analysis MH - Pilot Projects MH - Asian MH - United States PMC - PMC13245547 OTO - NOTNLM OT - diabetes OT - household health benefits OT - lifestyle intervention OT - social networks OT - social partners COIS- Conflicts of Interest: None declared. EDAT- 2026/06/08 19:40 MHDA- 2026/06/11 12:40 PMCR- 2026/06/08 CRDT- 2026/06/08 12:44 PHST- 2025/08/14 00:00 [received] PHST- 2026/02/15 00:00 [revised] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/06/11 12:40 [medline] PHST- 2026/06/08 19:40 [pubmed] PHST- 2026/06/08 12:44 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - v10i1e82438 [pii] AID - 82438 [pii] AID - 10.2196/82438 [doi] PST - epublish SO - JMIR Form Res. 2026 Jun 8;10:e82438. doi: 10.2196/82438. PMID- 42258187 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260803 IS - 2168-6211 (Electronic) IS - 2168-6203 (Print) IS - 2168-6203 (Linking) VI - 180 IP - 8 DP - 2026 Aug 1 TI - Smartphone Acquisition and Use at Age 13 Years and Health Outcomes at Age 14 Years. PG - 858-866 LID - 10.1001/jamapediatrics.2026.2118 [doi] AB - IMPORTANCE: Smartphone acquisition and use under age 13 years is common and has been linked to adverse health implications. Although delaying acquisition until after age 13 years is often recommended, evidence supporting this guideline remains limited. OBJECTIVE: To quantify the associations of smartphone acquisition around age 13 years and smartphone use with depression, obesity, and insufficient sleep at age 14 years. DESIGN, SETTING, AND PARTICIPANTS: In this cohort study of youth from the Adolescent Brain Cognitive Development Study, eligible participants were study participants who did not have a smartphone by the 13-year-old assessment. Mixed-effects regression models were applied to quantify associations of past-year smartphone acquisition and use with health outcomes adjusting for pre-exposure depression, obesity and sleep, multiple socioeconomic and parental confounders, and use of other devices. Analyses were conducted between November 2025 and April 2026. EXPOSURES: Smartphone acquisition and self-reported smartphone use duration (smartphone time). MAIN OUTCOMES: Odds ratios (ORs) for associations with depression diagnosis (based on a validated computerized diagnostic assessment), obesity (body mass index above 95th percentile), and insufficient sleep (less than 8 hours/night). RESULTS: Participants included 1959 youth (803 girls [41.0%]; 292 Black [14.9%], 314 Hispanic [16.0%], 1661 White [84.8%]) followed up from the 3-year (mean [SD] age, 12.7 [0.6] years) to the 4-year (mean [SD] age, 14.0 [0.7] years) assessment. Between the 3- and 4-year assessments, 1230 participants acquired a smartphone and 729 did not. Smartphone acquisition was not significantly associated with depression (OR, 1.45; 95% CI, 0.98-2.14) or obesity (OR, 1.02; 95% CI, 0.71-1.46), but was associated with insufficient sleep (OR, 1.29; 95% CI, 1.03-1.62) at follow-up. Among those who had acquired a smartphone, total smartphone time (standardized z score) was associated with depression (OR, 1.22; 95% CI, 1.01-1.80), obesity (OR, 1.34; 95% CI, 1.09-1.65), and insufficient sleep (OR, 1.28; 95% CI, 1.12-1.47). Placing smartphones outside the bedroom at bedtime was associated with lower odds of insufficient sleep (OR, 0.64; 95% CI, 0.47-0.87). CONCLUSIONS AND RELEVANCE: The results of this cohort study suggest that simply smartphone acquisition at age 13 years was not associated with depression or with obesity, but was associated with insufficient sleep at age 14 years; however, the amount of smartphone use was associated with higher odds of all 3 outcomes. Behavioral interventions like limiting smartphone time and keeping smartphones out of bedrooms at night may protect adolescents from potential adverse health outcomes. Findings offer insights to guide caregivers on adolescent smartphone use and inform policies aimed at protecting youth, such as delaying smartphone acquisition until age 13 years. FAU - Bren, Ziv AU - Bren Z AD - Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania. AD - Lifespan Brain Institute of CHOP and Penn Medicine, Philadelphia, Pennsylvania. FAU - Tran, Kate T AU - Tran KT AD - Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania. AD - Lifespan Brain Institute of CHOP and Penn Medicine, Philadelphia, Pennsylvania. FAU - Visoki, Elina AU - Visoki E AD - Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania. AD - Lifespan Brain Institute of CHOP and Penn Medicine, Philadelphia, Pennsylvania. FAU - Waasdorp, Tracy E AU - Waasdorp TE AD - Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania. AD - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia. FAU - Moore, Tyler M AU - Moore TM AD - Lifespan Brain Institute of CHOP and Penn Medicine, Philadelphia, Pennsylvania. AD - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia. FAU - Pimentel, Samuel D AU - Pimentel SD AD - Department of Statistics, University of California, Berkeley. FAU - Barzilay, Ran AU - Barzilay R AD - Department of Child and Adolescent Psychiatry and Behavioral Sciences, Children's Hospital of Philadelphia (CHOP), Philadelphia, Pennsylvania. AD - Lifespan Brain Institute of CHOP and Penn Medicine, Philadelphia, Pennsylvania. AD - Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia. LA - eng PT - Journal Article PL - United States TA - JAMA Pediatr JT - JAMA pediatrics JID - 101589544 SB - IM MH - Humans MH - *Smartphone/statistics & numerical data MH - Adolescent MH - Female MH - Male MH - *Depression/epidemiology/etiology MH - *Obesity/epidemiology MH - Cohort Studies MH - *Pediatric Obesity/epidemiology MH - *Sleep Deprivation/epidemiology MH - Sleep Duration PMC - PMC13247848 COIS- Conflict of Interest Disclosures: Dr Visoki reported that her spouse is the founder and CEO of Kidas. Dr Barzilay reported grants from National Institute of Mental Health (NIMH) during the conduct of the study; he reported advisory board service with Children and Screens and with Taliaz Health, in which he also holds equity, outside the submitted work. No other disclosures were reported. EDAT- 2026/06/08 12:39 MHDA- 2026/08/03 12:42 PMCR- 2027/06/08 CRDT- 2026/06/08 11:33 PHST- 2026/08/03 12:42 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 11:33 [entrez] PHST- 2027/06/08 00:00 [pmc-release] AID - 2849461 [pii] AID - poi260030 [pii] AID - 10.1001/jamapediatrics.2026.2118 [doi] PST - ppublish SO - JAMA Pediatr. 2026 Aug 1;180(8):858-866. doi: 10.1001/jamapediatrics.2026.2118. PMID- 42257889 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261028 IS - 1435-165X (Electronic) IS - 1018-8827 (Linking) VI - 35 IP - 9 DP - 2026 Sep TI - Impact of school physical activity on physical and mental health in children and adolescents: A Meta-analysis based on RE-AIM. PG - 2685-2702 LID - 10.1007/s00787-026-03069-5 [doi] AB - The RE-AIM framework was used to assess and analyze the impact of school physical activity on children and adolescents' physical and mental health. A search of PubMed, Cochrane Library, Embase, Scopus, EBSCO, and Web of Science was conducted from when the databases were created until December 2024. Articles included studies on school-based physical activity interventions and physical and mental health of children and adolescents. The screened literature was evaluated for quality, data extraction, standardized mean difference (SMD), Mean difference(MD) and confidence intervals (95% CI) were used as effect indicators. Two researchers independently screened the literature, extracted data, and assessed the risk of bias for the included studies. Preferred reporting items were used using systematic evaluation and meta-analysis guidelines combined with meta-analysis with the RE-AIM framework. A total of 19 studies that met the inclusion criteria were included in the meta-analysis, and the results of the meta-analysis showed that school physical activity improved adolescents' and children's athletic ability (SMD = 0.33, 95% CI = 0.23 ~ 0.43), reduced BMI (MD=-0.50, 95% CI=-0.81~-0.19) and improved Fitness self-perceptions (SMD = 0.31, 95% CI = 0.22 ~ 0.40). In terms of mental health, school physical activity improved children and adolescents' self-reported questionnaire scores (SMD = 0.21,95%CI = 0.12 ~ 0.30) and reduced anxiety, depression and stress levels (MD=-0.53,95%CI=-0.85~-0.22). That is, school physical activity is associated with improvements in both physical health and the mental health of adolescents and children. In addition, the RE-AIM framework reported the effectiveness of sports interventions on health, with higher proportions of the Reach, Efficacy, and Adoption dimensions in the RE-AIM framework than in Implementation and Maintenance. A comprehensive assessment of the impact of school physical activity was conducted through meta-analysis and RE-AIM framework, which showed that school physical activity is associated with improvements in both the physical and mental health of children and adolescents and that RE-AIM framework reported the quality of physical activity interventions to improve the physical and mental health of children and adolescents, achieving a balance of internal and external validity in comparison. CI - (c) 2026. Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Li, Congcong AU - Li C AD - College of Sports Science, Shenyang Normal University, Shenyang, China. AD - Department of Physical Education, Shanghai University of Medicine & Health Science, Shanghai, China. FAU - Wang, Yezheng AU - Wang Y AD - College of Sports Science, Shenyang Normal University, Shenyang, China. FAU - Zhao, Wei AU - Zhao W AD - College of Sports Science, Shenyang Normal University, Shenyang, China. FAU - Yan, Xu AU - Yan X AD - College of Sports Science, Shenyang Normal University, Shenyang, China. FAU - Liu, Kaihang AU - Liu K AD - College of Sports Science, Shenyang Normal University, Shenyang, China. FAU - Zhong, Jingyi AU - Zhong J AD - College of Sports Science, Shenyang Normal University, Shenyang, China. FAU - Wang, Liyan AU - Wang L AD - College of Rehabilitation, Shanghai University of Medicine & Health Science, Shanghai, China. FAU - Wang, Hongbiao AU - Wang H AD - Department of Physical Education, Shanghai University of Medicine & Health Science, Shanghai, China. FAU - Wang, Lijuan AU - Wang L AD - College of Sports Science, Shenyang Normal University, Shenyang, China. wlj_sunny@synu.edu.cn. LA - eng PT - Journal Article PT - Meta-Analysis PT - Review DEP - 20260608 PL - Germany TA - Eur Child Adolesc Psychiatry JT - European child & adolescent psychiatry JID - 9212296 SB - IM MH - Humans MH - Adolescent MH - Child MH - *Exercise/psychology MH - *Mental Health MH - *Schools MH - *Physical Fitness OTO - NOTNLM OT - Adolescents OT - Children OT - Mental health OT - Physical activity OT - Physical health OT - School interventions COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/06/08 12:39 MHDA- 2026/10/25 03:35 CRDT- 2026/06/08 11:13 PHST- 2025/05/22 00:00 [received] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/10/25 03:35 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 11:13 [entrez] AID - 10.1007/s00787-026-03069-5 [pii] AID - 10.1007/s00787-026-03069-5 [doi] PST - ppublish SO - Eur Child Adolesc Psychiatry. 2026 Sep;35(9):2685-2702. doi: 10.1007/s00787-026-03069-5. Epub 2026 Jun 8. PMID- 42257240 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260612 IS - 1473-0766 (Electronic) IS - 0951-3590 (Linking) VI - 42 IP - 1 DP - 2026 Dec 31 TI - Association between GLM7 and female infertility: a cross-sectional analysis of NHANES 2013-2018. PG - 2686485 LID - 10.1080/09513590.2026.2686485 [doi] AB - OBJECTIVE: Female infertility is a common reproductive disorder influenced by metabolic dysfunction. The glycolipid metabolism 7 factors (GLM7) is a composite metabolic index integrating age, BMI, glucose, insulin, and lipid profiles. This study aimed to examine its association with female infertility in a nationally representative population. METHODS: Data from 1,405 female participants aged 18-45 years from the 2013-2018 cycles of the National Health and Nutrition Examination Survey were analyzed. We used survey-weighted logistic regression models and restricted cubic splines to assess the association between GLM7 and infertility. Receiver operating characteristic (ROC) curves were used to assess the diagnostic accuracy. RESULTS: A total of 167 participants (11.9%) reported infertility. After full adjustment, higher GLM7 levels were independently associated with increased odds of infertility (odds ratio (OR) = 1.401, 95% CI: 1.028-1.909, p = 0.034). A positive linear association was observed, with a potential plateau effect at GLM7 approximately 6.98. GLM7 showed modest discriminative ability (AUC = 0.596, 95%CI: 0.552-0.639). CONCLUSIONS: GLM7 was positively associated with female infertility. As a multidimensional metabolic indicator, GLM7 may provide complementary information for reproductive health research. However, its modest discriminative performance suggests limited value as a standalone screening tool, warranting further validation in longitudinal and clinical studies. FAU - Dong, Tingting AU - Dong T AUID- ORCID: 0000-0003-1035-6687 AD - Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province, People's Republic of China. FAU - Gao, Jie AU - Gao J AUID- ORCID: 0009-0006-8586-0772 AD - School of Nursing and Rehabilitation, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, People's Republic of China. FAU - Wang, Xietong AU - Wang X AUID- ORCID: 0009-0006-3301-9105 AD - Department of Obstetrics and Gynecology, Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province, People's Republic of China. AD - Shandong Provincial Maternal and Child Health Care Hospital, Jinan, Shandong Province, People's Republic of China. AD - Key Laboratory of Maternal-Fetal Medicine of National Health Commission of China, Maternal and Child Health Care Hospital of Shandong Province Affiliated with Qingdao University, Qingdao University, Jinan, Shandong Province, People's Republic of China. LA - eng PT - Journal Article DEP - 20260608 PL - England TA - Gynecol Endocrinol JT - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JID - 8807913 RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Female MH - Adult MH - *Infertility, Female/blood/epidemiology/metabolism MH - Cross-Sectional Studies MH - Young Adult MH - Nutrition Surveys MH - Adolescent MH - Middle Aged MH - United States/epidemiology MH - Body Mass Index MH - Blood Glucose/metabolism OTO - NOTNLM OT - Female OT - GLM7 OT - glycolipid metabolism OT - infertility OT - reproductive health EDAT- 2026/06/08 12:39 MHDA- 2026/06/12 06:37 CRDT- 2026/06/08 07:47 PHST- 2026/06/12 06:37 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 07:47 [entrez] AID - 10.1080/09513590.2026.2686485 [doi] PST - ppublish SO - Gynecol Endocrinol. 2026 Dec 31;42(1):2686485. doi: 10.1080/09513590.2026.2686485. Epub 2026 Jun 8. PMID- 42257148 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 2249-4863 (Print) IS - 2278-7135 (Electronic) IS - 2249-4863 (Linking) VI - 15 IP - 3 DP - 2026 Mar TI - Exploring the effects of high fat, salt, and sugar (HFSS) food consumption among undergraduate medical students: A cross-sectional study. PG - 1306-1314 LID - 10.4103/jfmpc.jfmpc_94_25 [doi] AB - BACKGROUND: Adolescents who are overweight or obese are more likely to develop non-communicable diseases (NCDs) in their early adult years, including diabetes, cardiovascular disease, hypertension, and dyslipidaemia. To address the growing epidemic of childhood and adult obesity, immediate action is needed. Obesity and the prevalence of non-communicable diseases are strongly linked to eating habits. METHODOLOGY: A pre-tested, validated questionnaire was circulated among undergraduate MBBS students from various medical colleges. RESULTS: One hundred seventy MBBS students from four other medical colleges participated in this online survey. The questionnaire was circulated via Google Forms. The mean age of participants was 21.57 (+1.47). Zomato (57, 33%) and Swiggy (52, 31%) were the most used applications by the participants. One hundred thirty-four (79%) participants had incorrect knowledge about added sugar in the diet cola drinks. One hundred nineteen (70%) participants had incorrect knowledge about added salt in bread. Thirty-five of 107 (33%) females had a waist hip ratio (WHR) of more than 0.85, and 15/63 (24%) males had a WHR of more than 0.90, which implies an increased chance of obesity, cardiovascular risks, and other non-communicable diseases in the future. CONCLUSION: The study reveals a high prevalence of HFSS food consumption among undergraduate medical students, with online food delivery platforms playing a central role in facilitating this dietary behaviour. CI - Copyright: (c) 2026 Journal of Family Medicine and Primary Care. FAU - Singh, Garima AU - Singh G AD - Department of Community Medicine, Heritage Institute of Medical Sciences, Varanasi, Uttar Pradesh, India. FAU - Jaiswal, Abhishek AU - Jaiswal A AD - Department of Community Medicine, Banaras Hindu University, Varanasi, Uttar Pradesh, India. LA - eng PT - Journal Article DEP - 20260420 PL - India TA - J Family Med Prim Care JT - Journal of family medicine and primary care JID - 101610082 PMC - PMC13241118 OTO - NOTNLM OT - Fast food consumption OT - non-communicable diseases OT - obesity COIS- There are no conflicts of interest. EDAT- 2026/06/08 12:38 MHDA- 2026/06/08 12:39 PMCR- 2026/03/01 CRDT- 2026/06/08 07:46 PHST- 2025/01/15 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/02/11 00:00 [accepted] PHST- 2026/06/08 12:39 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 07:46 [entrez] PHST- 2026/03/01 00:00 [pmc-release] AID - JFMPC-15-1306 [pii] AID - 10.4103/jfmpc.jfmpc_94_25 [doi] PST - ppublish SO - J Family Med Prim Care. 2026 Mar;15(3):1306-1314. doi: 10.4103/jfmpc.jfmpc_94_25. Epub 2026 Apr 20. PMID- 42257122 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 2249-4863 (Print) IS - 2278-7135 (Electronic) IS - 2249-4863 (Linking) VI - 15 IP - 3 DP - 2026 Mar TI - Screen time and its determinants among adolescents in Chennai: A cross-sectional study. PG - 1160-1164 LID - 10.4103/jfmpc.jfmpc_442_25 [doi] AB - BACKGROUND: Screen time (ST) has become a critical factor influencing adolescent health. With the rapid expansion of smartphones, tablets, computers and internet access, the ways in which they interact with their environment have undergone massive transformation. This study focuses on the use of screen time and its association with demographic and lifestyle factors in Chennai, India. METHODS: The study was a descriptive cross-sectional study among 610 adolescents (53.3% from government aided schools and 46.7% from private school) from Chennai. Data was collected using structured proforma and validated questionnaire (QueST) that was then analysed for ST determinants. RESULTS: The study revealed an average ST of 2.45 +/- 1.19 hours on weekdays and 4.21 +/- 1.94 hours on weekends. Recreational activities such as video, gaming and social media were the predominant contributors. Increased ST (>2 hours/day) was significantly associated with age (17 years), gender (female), type of school (private), decreased sleep duration, absence of physical activity, incomplete homework, lack of peer interaction, spectacle use and overweight/obesity. CONCLUSION: The average ST spent by adolescents is more than the recommendation. This study highlights the need for optimal ST practices for promoting a balanced lifestyle among Adolescents. CI - Copyright: (c) 2026 Journal of Family Medicine and Primary Care. FAU - Amuthan, Shwetha AU - Amuthan S AD - Senior Resident, Department of Paediatrics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India. FAU - Mohan, Ram AU - Mohan R AD - Assistant Professor, Department of Paediatrics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India. FAU - Ravichandran, Latha AU - Ravichandran L AD - Professor, Department of Paediatrics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India. FAU - Premkumar, Sarala AU - Premkumar S AD - Professor, Department of Paediatrics, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India. LA - eng PT - Journal Article DEP - 20260420 PL - India TA - J Family Med Prim Care JT - Journal of family medicine and primary care JID - 101610082 PMC - PMC13241144 OTO - NOTNLM OT - Adolescents OT - BMI OT - Chennai OT - physical activity OT - screentime COIS- There are no conflicts of interest. EDAT- 2026/06/08 12:39 MHDA- 2026/06/08 12:40 PMCR- 2026/03/01 CRDT- 2026/06/08 07:46 PHST- 2025/03/17 00:00 [received] PHST- 2025/10/25 00:00 [revised] PHST- 2025/11/03 00:00 [accepted] PHST- 2026/06/08 12:40 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 07:46 [entrez] PHST- 2026/03/01 00:00 [pmc-release] AID - JFMPC-15-1160 [pii] AID - 10.4103/jfmpc.jfmpc_442_25 [doi] PST - ppublish SO - J Family Med Prim Care. 2026 Mar;15(3):1160-1164. doi: 10.4103/jfmpc.jfmpc_442_25. Epub 2026 Apr 20. PMID- 42256855 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 1662-5153 (Print) IS - 1662-5153 (Electronic) IS - 1662-5153 (Linking) VI - 20 DP - 2026 TI - Quantum-entangled feature selection and spiking graph transformer networks for early detection of childhood behavioral markers. PG - 1797210 LID - 10.3389/fnbeh.2026.1797210 [doi] LID - 1797210 AB - INTRODUCTION: Early identification of childhood behavioural markers using wearable sensing is important for timely intervention in developmental and sleep-related disorders. Wrist-worn accelerometer data provide objective measures of behavioural regulation by capturing actigraphy-derived states such as Sleep, Wake, and Transitional periods. However, existing deep learning methods for behavioural state detection often face challenges related to redundant features, sensitivity to sensor noise, limited robustness in long-term wearable deployment, and high energy consumption. METHODS: This study proposes a Quantum Variational Feature Selection-Spiking Graph Transformer Network (QVFS-SGTN), a hybrid quantum-neuromorphic framework for robust and energy-efficient behavioural state classification. The prediction task was defined as a three-class classification problem involving Sleep, Wake, and Transitional behavioural states from high-frequency wrist-worn accelerometer data. The proposed model integrates a parameterized quantum circuit-based feature selector to identify non-linear and entangled sensor correlations. Selected features are then processed by a spiking graph transformer network, which models temporal dependencies through event-driven self-attention and neuromorphic neuron dynamics. Experiments were conducted using the Child Mind Institute wearable dataset, with additional cross-dataset validation performed on the external Multi-Ethnic Study of Atherosclerosis sleep dataset. RESULTS: The proposed QVFS-SGTN framework achieved state-of-the-art performance on the Child Mind Institute wearable dataset, with an accuracy of 0.968, an F1-score of 0.968, and an AUC of 0.991. Robustness evaluation demonstrated stable performance under significant Gaussian noise, maintaining accuracy above 92%. Energy analysis showed a 40-55% reduction in computational cost compared with conventional deep learning models. In cross-dataset evaluation using the MESA sleep dataset, the model achieved an accuracy of 0.931 without fine-tuning, indicating strong generalization capability. DISCUSSION: The findings demonstrate that combining quantum-enhanced feature selection with spiking graph-based temporal modelling can improve the robustness, accuracy, and energy efficiency of wearable behavioural state detection. The QVFS-SGTN framework effectively addresses key limitations of existing deep learning approaches, including feature redundancy, sensor noise sensitivity, and computational cost. These results support the potential of the proposed hybrid quantum-neuromorphic model for scalable, long-term, real-world paediatric behavioural monitoring. CI - Copyright (c) 2026 M, Joseph, Patil and K. FAU - M, Karthiga AU - M K AD - Department of Computer Science and Engineering, Bannari Amman Institute of Technology, Sathyamangalam, Tamil Nadu, India. AD - Postdoctoral Researcher, Multimedia University, Melaka, Malaysia. FAU - Joseph, Emerson Raja AU - Joseph ER AD - Faculty of Engineering and Technology Centre for Advanced Analytics, COE of Artificial Intelligence, Multimedia University, Melaka, Malaysia. FAU - Patil, Subhash AU - Patil S AD - Department of Surgery, International Medical University, Management and Science University, Shah Alam, Malaysia. FAU - K, Saranya AU - K S AD - Department of Computer Science and Engineering, Bannari Amman Institute of Technology, Sathyamangalam, Tamil Nadu, India. LA - eng PT - Journal Article DEP - 20260522 PL - Switzerland TA - Front Behav Neurosci JT - Frontiers in behavioral neuroscience JID - 101477952 PMC - PMC13236668 OTO - NOTNLM OT - childhood behavioral markers OT - graph transformer OT - neuromorphic computing OT - quantum variational feature selection OT - sleep-wake detection OT - spiking neural networks OT - wearable accelerometers COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/08 12:39 MHDA- 2026/06/08 12:40 PMCR- 2026/05/22 CRDT- 2026/06/08 07:44 PHST- 2026/01/27 00:00 [received] PHST- 2026/04/27 00:00 [revised] PHST- 2026/04/29 00:00 [accepted] PHST- 2026/06/08 12:40 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 07:44 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - 10.3389/fnbeh.2026.1797210 [doi] PST - epublish SO - Front Behav Neurosci. 2026 May 22;20:1797210. doi: 10.3389/fnbeh.2026.1797210. eCollection 2026. PMID- 42256484 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2421-4248 (Electronic) IS - 1121-2233 (Print) IS - 1121-2233 (Linking) VI - 66 IP - 4 DP - 2025 Dec TI - The digital tether: a SA-SV based survey on smartphone addiction among young adults in Southern Italy. PG - E466-E478 LID - 10.15167/2421-4248/jpmh2025.66.4.3771 [doi] AB - INTRODUCTION: In the post-pandemic era, smartphone usage has surged globally, particularly among young adults. While these devices offer convenience and connectivity, their excessive use has raised concerns about behavioral addiction and psychological well-being. This study investigates the prevalence of problematic smartphone use among young adults in Southern Italy, focusing on usage patterns and socio-demographic correlations. METHODS: A cross-sectional survey was conducted between March and June 2025 using an anonymous online questionnaire. The instrument combined ad hoc questions on lifestyle and digital habits with the validated Smartphone Addiction Scale-Short Version (SAS-SV). Participants aged 18-40 were recruited primarily from Sicily and Calabria via university and community networks. Data were analyzed using non-parametric statistical tests and chi-square analysis. RESULTS: The final sample included 451 respondents (average age: 22.42 years), predominantly Italian and non-working students. The SAS-SV identified smartphone addiction in 21.3% of participants, with no significant gender differences. Most users engaged with smartphones for leisure, social media, and entertainment. Significant associations were found between SAS scores and variables such as region, education level, and income. Notably, higher scores correlated with emotional reliance on smartphones and difficulty disengaging from use. CONCLUSION: Problematic smartphone use affects over one-fifth of young adults in Southern Italy, driven more by app features than screen time alone. These findings underscore the need for targeted public health strategies, including early screening and behavioral interventions, to address digital dependency and promote healthier technology habits in this demographic. CI - (c)2026 Pacini Editore SRL, Pisa, Italy. FAU - Venuto, Roberto AU - Venuto R AD - Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy. AD - Department of Prevention, Local Health Authority of Messina, Messina, Italy. FAU - Rizzo, Caterina Elisabetta AU - Rizzo CE AD - Department of Prevention, Local Health Authority of Messina, Messina, Italy. AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. FAU - Genovese, Giovanni AU - Genovese G AD - Department of Prevention, Local Health Authority of Messina, Messina, Italy. AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. FAU - Trimarchi, Giuseppe AU - Trimarchi G AD - SIR, University of Messina, Messina, Italy. FAU - LA Spada, Giuseppe AU - LA Spada G AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. FAU - Squeri, Raffaele AU - Squeri R AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. FAU - LA Fauci, Vincenza AU - LA Fauci V AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. FAU - Genovese, Cristina AU - Genovese C AD - Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina, Italy. LA - eng PT - Journal Article DEP - 20260228 PL - Italy TA - J Prev Med Hyg JT - Journal of preventive medicine and hygiene JID - 9214440 SB - IM MH - Humans MH - *Smartphone/statistics & numerical data MH - Italy/epidemiology MH - Female MH - Young Adult MH - Male MH - Cross-Sectional Studies MH - Adolescent MH - Surveys and Questionnaires MH - *Internet Addiction Disorder/epidemiology MH - Adult MH - *Behavior, Addictive/epidemiology MH - Prevalence MH - Digital Media PMC - PMC13235401 OTO - NOTNLM OT - Digital behavior OT - SAS-SV OT - Smartphone addiction OT - Smartphone problematic use OT - Young adults COIS- The authors declare no conflict of interest. EDAT- 2026/06/08 12:38 MHDA- 2026/06/12 06:39 PMCR- 2026/02/28 CRDT- 2026/06/08 07:41 PHST- 2026/06/12 06:39 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 07:41 [entrez] PHST- 2026/02/28 00:00 [pmc-release] AID - 10.15167/2421-4248/jpmh2025.66.4.3771 [doi] PST - epublish SO - J Prev Med Hyg. 2026 Feb 28;66(4):E466-E478. doi: 10.15167/2421-4248/jpmh2025.66.4.3771. eCollection 2025 Dec. PMID- 42256013 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 2641-7804 (Electronic) IS - 2641-7804 (Linking) VI - 7 IP - 4 DP - 2025 TI - Associations Between Social Media Usage, Physical Activity and Flourishing in Rural University Students. PG - 128-136 LID - 10.13023/jah.0704.08 [doi] AB - INTRODUCTION: Most adolescents and young adults report significant use of social media.1-3 However, there is limited research on the effect of social media use, specifically on physical activity and flourishing. PURPOSE: This pilot research study examines the correlation between social media usage and the physical activity and flourishing levels of college students at a rural university in Appalachia. METHODS: The authors conducted a survey including the validated Secure Flourishing Index and Stanford Leisure-Time Activity Categorical Item, containing questions on social media use and demographics. Spearman's rho was used for nonparametric correlations. Pearson's correlation was used to determine the correlation of flourishing with physical activity levels. RESULTS: Time spent on Threads per login was positively associated with higher physical activity (pppp <0.001). Implications: Social media use, both frequency and time spent on the platforms, can impact how college students attending a rural university flourish and participate in physical activity. Continued research in this area should investigate the content on social media for its impact on different domains of flourishing including physical and mental health. CI - Copyright (c) 2025 Anna Dysart and Minu Sara Thomas. FAU - Dysart, Anna AU - Dysart A AD - Western Carolina University. FAU - Thomas, Minu Sara AU - Thomas MS AD - Western Carolina University. LA - eng PT - Journal Article DEP - 20251201 PL - United States TA - J Appalach Health JT - Journal of Appalachian health JID - 101747123 PMC - PMC13239628 OTO - NOTNLM OT - Appalachia OT - college students OT - flourishing OT - health OT - physical activity OT - social media COIS- Cover Page Footnote: No competing financial or editorial interests were reported by the authors of this paper. EDAT- 2026/06/08 12:39 MHDA- 2026/06/08 12:40 PMCR- 2025/12/01 CRDT- 2026/06/08 07:37 PHST- 2026/06/08 12:40 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 07:37 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - jah-7-4-128 [pii] AID - 10.13023/jah.0704.08 [doi] PST - epublish SO - J Appalach Health. 2025 Dec 1;7(4):128-136. doi: 10.13023/jah.0704.08. eCollection 2025. PMID- 42255899 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Genotype-phenotype correlations in EPCAM-associated congenital tufting enteropathy: a case report and systematic review. PG - 1830464 LID - 10.3389/fped.2026.1830464 [doi] LID - 1830464 AB - BACKGROUND: Congenital tufting enteropathy (CTE) is a rare autosomal-recessive enteropathy caused by EPCAM variants. While the clinical spectrum ranges from intractable diarrhea to manageable outcomes, the genotype-phenotype correlation remains undefined. METHODS: We report a case of an infant diagnosed with CTE carrying a novel frameshift variant (c.315delT), and present a systematic review of previously published molecularly confirmed cases. Genotypes were stratified into truncating (nonsense, frameshift, large deletions) and non-truncating (missense, splicing, in-frame indel) groups to assess their impact on intestinal failure severity. RESULTS: The index patient, carrying a homozygous truncating variant, presented with severe malnutrition and intestinal failure. In the pooled cohort (n = 150), truncating variants were significantly associated with dependency on total parenteral nutrition (TPN) compared to non-truncating variants (OR 2.37, 95% CI 1.15-4.90, p = 0.020). Sensitivity analysis supported this association (OR 2.42, 95% CI 1.07-5.47, p = 0.045). Geographically, truncating variants were enriched in the Eastern Mediterranean Region (OR 9.32, p < 0.001). CONCLUSIONS: Truncating EPCAM variants showed a preliminary but significant clinical association with severe intestinal failure requiring TPN. These findings support early risk stratification for aggressive nutritional management but warrant further validation in prospective cohorts. CI - (c) 2026 Zhao, Zheng, Liu, Liu, Lu and Yan. FAU - Zhao, Liqian AU - Zhao L AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Zheng, Yucan AU - Zheng Y AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Liu, Hao AU - Liu H AD - Department of Infection, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Liu, Zhifeng AU - Liu Z AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Lu, Yan AU - Lu Y AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Yan, Kunlong AU - Yan K AD - Department of Gastroenterology, Children's Hospital of Nanjing Medical University, Nanjing, China. LA - eng PT - Journal Article DEP - 20260521 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13233504 OTO - NOTNLM OT - EPCAM OT - congenital tufting enteropathy OT - genotype-phenotype analysis OT - intestinal failure OT - parenteral nutrition COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/08 12:38 MHDA- 2026/06/08 12:39 PMCR- 2026/05/21 CRDT- 2026/06/08 07:36 PHST- 2026/03/14 00:00 [received] PHST- 2026/05/01 00:00 [revised] PHST- 2026/05/01 00:00 [accepted] PHST- 2026/06/08 12:39 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 07:36 [entrez] PHST- 2026/05/21 00:00 [pmc-release] AID - 10.3389/fped.2026.1830464 [doi] PST - epublish SO - Front Pediatr. 2026 May 21;14:1830464. doi: 10.3389/fped.2026.1830464. eCollection 2026. PMID- 42254656 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260813 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Fecal microbiota composition concerning body mass index and early-life factors in Mexican preschool-aged children: a cross-sectional study. PG - e21253 LID - 10.7717/peerj.21253 [doi] LID - e21253 AB - BACKGROUND: The gut microbiota maturation extends beyond the first two years of life. Early perinatal and postnatal factors may influence the child's nutritional status, which, in turn, can affect the composition of their gut microbiota. METHODS: This cross-sectional study characterized the gut microbiota of 84 preschool children (ages 3 to 5) from semi-urban and urban areas in Veracruz, Mexico. Fecal samples were analyzed using 16S rRNA gene sequencing. Perinatal and early-life exposures were retrieved retrospectively using a validated, interviewer-administered questionnaire, while current anthropometric measurements and dietary patterns were evaluated. Children were classified by Body Mass Index (BMI) as underweight (UW), normal weight (NW), or overweight/obese (OW). RESULTS: Clinical factors such as prematurity and early feeding showed weak associations with BMI. The dietary patterns exhibited general homogeneity, showing a Western diet with no significant changes in relation to BMI. The predominant bacterial phyla were Bacillota and Bacteroidota across all BMI groups. Alpha diversity showed significant differences according to BMI categories, while no significant differences in beta diversity, or the relative abundance of major phyla, were observed. At the family level, Prevotellaceae was more abundant in underweight children, while Lachnospiraceae was more prevalent in those with higher BMI. However, these trends were not statistically significant. The findings suggest that, within this narrow age range and shared environment, gut microbiota composition is broadly similar regardless of BMI and dietary patterns, highlighting the complexity of microbiota-host interactions in early childhood. Further studies integrating functional analyses are needed to clarify the causal links between gut microbiota and a child's weight status. CI - (c)2026 Hernandez-Rodriguez et al. FAU - Hernandez-Rodriguez, Dolores AU - Hernandez-Rodriguez D AD - Instituto de Ciencias Basicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico. FAU - Contreras, Astrid AU - Contreras A AD - Centro de Investigaciones Biomedicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico. FAU - Melgar Lalanne, Guiomar AU - Melgar Lalanne G AD - Instituto de Ciencias Basicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico. FAU - Lara Arellano, Silvia Socorro AU - Lara Arellano SS AD - Facultad de Enfermeria, Universidad Veracruzana, Xalapa, Veracruz, Mexico. FAU - Meza, Jose Enrique AU - Meza JE AD - Centro de Investigaciones Biomedicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico. FAU - Licona Cassani, Cuauhtemoc AU - Licona Cassani C AD - Departamento de Ingenieria Celular y Biocatalisis, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico. FAU - Viveros, Rubi AU - Viveros R AD - Centro de Investigaciones Biomedicas, Universidad Veracruzana, Xalapa, Veracruz, Mexico. LA - eng SI - figshare/10.6084/m9.figshare.30290248.v1 PT - Journal Article DEP - 20260603 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 RN - 0 (RNA, Ribosomal, 16S) SB - IM MH - Humans MH - Cross-Sectional Studies MH - Child, Preschool MH - Mexico MH - *Body Mass Index MH - Male MH - Female MH - *Feces/microbiology MH - *Gastrointestinal Microbiome MH - RNA, Ribosomal, 16S/genetics MH - Thinness/microbiology MH - Nutritional Status MH - Overweight/microbiology MH - Retrospective Studies PMC - PMC13242193 OTO - NOTNLM OT - Body mass index OT - Childhood OT - Clinical data OT - Gut microbiota OT - Nutritional status COIS- The authors declare there are no competing interests. EDAT- 2026/06/08 12:39 MHDA- 2026/06/11 18:36 PMCR- 2026/06/03 CRDT- 2026/06/08 07:25 PHST- 2025/10/15 00:00 [received] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/06/11 18:36 [medline] PHST- 2026/06/08 12:39 [pubmed] PHST- 2026/06/08 07:25 [entrez] PHST- 2026/06/03 00:00 [pmc-release] AID - 21253 [pii] AID - 10.7717/peerj.21253 [doi] PST - epublish SO - PeerJ. 2026 Jun 3;14:e21253. doi: 10.7717/peerj.21253. eCollection 2026. PMID- 42254612 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Ontology-based dietary recommendation system for Chinese children and adolescents: development and a pilot validation study. PG - 1780898 LID - 10.3389/fpubh.2026.1780898 [doi] LID - 1780898 AB - BACKGROUND: Dietary imbalances among Chinese children and adolescents are prevalent, but most recommender systems are adult-oriented and not adapted to Chinese dietary patterns or school-family meal contexts. This study aims to developed and evaluated an ontology-based dietary recommendation system for Chinese children and adolescents to improve their dietary status. METHODS: An ontology knowledge base was constructed from dietary guidelines, expert knowledge, and food and meal data. A multi-criteria decision framework generated feasible meal plans, optimized portion sizes with a genetic algorithm, and selected solutions that promote food diversity. We conducted a preliminary evaluation of the system in two pilot settings: (1) a group-level experiment using 30 days of school lunch data from a primary school, and (2) an individual-level experiment using 30 days of dietary records and health check-up data from 30 middle school students. Diet quality was assessed using the Chinese Children Dietary Index (CCDI), nutrient adequacy rates, and food-group diversity. RESULTS: In the group experiment, system-recommended lunches achieved a significantly higher average CCDI score (117.39 +/- 6.61) than actual school lunches (103.41 +/- 9.44, p < 0.001). In the individual experiment, recommended full-day meals scored higher in CCDI (110.91 +/- 9.70) compared with self-selected diets (90.61 +/- 10.77, p < 0.001). Across both settings, the system reduced deficiencies in vegetables, fruits, and aquatic products with consistent improvements in nutrient adequacy and food diversity, while maintaining alignment with dietary guidelines. CONCLUSION: To the best of our knowledge, this study presents the first ontology-driven dietary recommendation system tailored for Chinese children and adolescents. By integrating structured knowledge representation with advanced decision-making algorithms, the system demonstrates promising improvements in dietary quality, nutritional balance, and food diversity across both school and family scenarios. These findings highlight the system's potential as a practical tool for promoting healthy eating behaviors, and informing nutrition education. CI - Copyright (c) 2026 Zhang, Xu, An, Yang, Xie and Deng. FAU - Zhang, Zhiyu AU - Zhang Z AD - College of Biomedical Engineering and Instrument Science, Ministry of Education Key Laboratory of Biomedical Engineering, Zhejiang University, Hangzhou, China. FAU - Xu, Dongdong AU - Xu D AD - College of Biomedical Engineering and Instrument Science, Ministry of Education Key Laboratory of Biomedical Engineering, Zhejiang University, Hangzhou, China. FAU - An, Jiye AU - An J AD - College of Biomedical Engineering and Instrument Science, Ministry of Education Key Laboratory of Biomedical Engineering, Zhejiang University, Hangzhou, China. FAU - Yang, Min AU - Yang M AD - Department of Nutrition and Food Hygiene, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China. AD - Center of Clinical Big Data and Analytics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. FAU - Xie, Sasa AU - Xie S AD - Department of Nutrition and Food Hygiene, School of Public Health, Zhejiang University School of Medicine, Hangzhou, China. AD - Center of Clinical Big Data and Analytics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. FAU - Deng, Ning AU - Deng N AD - College of Biomedical Engineering and Instrument Science, Ministry of Education Key Laboratory of Biomedical Engineering, Zhejiang University, Hangzhou, China. AD - Binjiang Institute, Zhejiang University, Hangzhou, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260522 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Chinese people SB - IM MH - Humans MH - Pilot Projects MH - Child MH - Adolescent MH - China MH - Female MH - Male MH - *Nutrition Policy MH - *Diet MH - Schools MH - Knowledge Bases MH - East Asian People PMC - PMC13236952 OTO - NOTNLM OT - artificial intelligence OT - children and adolescents OT - dietary recommendation OT - multi-criteria decision-making OT - ontology COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/08 12:38 MHDA- 2026/06/12 06:38 PMCR- 2026/05/22 CRDT- 2026/06/08 07:25 PHST- 2026/01/05 00:00 [received] PHST- 2026/05/01 00:00 [revised] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/06/12 06:38 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 07:25 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1780898 [doi] PST - epublish SO - Front Public Health. 2026 May 22;14:1780898. doi: 10.3389/fpubh.2026.1780898. eCollection 2026. PMID- 42253746 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260608 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Serum BDNF as an integrative neuro-immunometabolic marker in adolescent polycystic ovary syndrome: divergent dietary and inflammatory associations across weight phenotypes. PG - 1830074 LID - 10.3389/fnut.2026.1830074 [doi] LID - 1830074 AB - BACKGROUND: Polycystic ovary syndrome (PCOS) in adolescence is characterized by hormonal imbalance, low-grade inflammation, oxidative stress, and metabolic dysfunction. Brain-derived neurotrophic factor (BDNF) regulates energy homeostasis and neuroimmune signaling and may act as a neuroimmunometabolic integrator in PCOS. METHODS: Forty adolescent females with PCOS (26 normal weight and 14 with overweight and obesity) were evaluated. Serum BDNF, omega-3 fatty acids (EPA, DHA), uric acid, metabolic and hormonal indices, and total antioxidant capacity (T-AOC) were measured. Dietary intake and physical activity were assessed using validated tools. RESULTS: Serum BDNF concentrations did not differ between BMI phenotypes. After FDR correction, significant dietary associations were observed only in normal-weight participants, including energy, protein, fat, and unsaturated fatty acids. No dietary associations remained significant in patients with overweight and obesity. Across both phenotypes, BDNF was positively associated with IL-1beta, MDA, T-AOC, EPA, and uric acid. IL-6, TNF-alpha, and DHA remained significant only in normal-weight participants. No associations were found with CRP, lipid profile, sex hormones, or glucose-insulin parameters. CONCLUSION: Circulating BDNF was associated with dietary, inflammatory, and oxidative parameters, with limited evidence for endocrine associations. These findings suggest that BDNF may reflect an integrated neuroimmunometabolic profile in adolescent PCOS and should be considered exploratory, requiring confirmation in longitudinal studies. CI - Copyright (c) 2026 Mizgier, Formanowicz, Sansoni, Jarzabek-Bielecka, Lombardi, Kedzia and Opydo-Szymaczek. FAU - Mizgier, Malgorzata AU - Mizgier M AD - Department of Sports Dietetics, Faculty of Health Sciences, Poznan University of Physical Education, Poznan, Poland. FAU - Formanowicz, Dorota AU - Formanowicz D AD - Chair and Department of Medical Chemistry and Laboratory Medicine, Poznan University of Medical Sciences, Poznan, Poland. FAU - Sansoni, Veronica AU - Sansoni V AD - Laboratory of Experimental Biochemistry and Advanced Diagnostics, I.R.C.C.S. Ospedale Galeazzi-Sant'Ambrogio, Milano, Italy. FAU - Jarzabek-Bielecka, Grazyna AU - Jarzabek-Bielecka G AD - Division of Gynecology, Department of Gynecology, Center of General Sexology and Sexology of Developmental Age, Poznan University of Medical Sciences, Poznan, Poland. FAU - Lombardi, Giovanni AU - Lombardi G AD - Laboratory of Experimental Biochemistry and Advanced Diagnostics, I.R.C.C.S. Ospedale Galeazzi-Sant'Ambrogio, Milano, Italy. AD - Department of Athletics, Strength and Conditioning, Poznan University of Physical Education, Poznan, Poland. FAU - Kedzia, Witold AU - Kedzia W AD - Division of Gynecology, Department of Gynecology, Center of General Sexology and Sexology of Developmental Age, Poznan University of Medical Sciences, Poznan, Poland. FAU - Opydo-Szymaczek, Justyna AU - Opydo-Szymaczek J AD - Department of Pediatric Dentistry, Poznan University of Medical Sciences, Poznan, Poland. LA - eng PT - Journal Article DEP - 20260521 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13233441 OTO - NOTNLM OT - BDNF OT - adolescence OT - antioxidant defence OT - diet OT - inflammation OT - insulin sensitivity OT - omega-3 fatty acids OT - oxidative stress COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author MM declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/06/08 12:38 MHDA- 2026/06/08 12:39 PMCR- 2026/05/21 CRDT- 2026/06/08 07:18 PHST- 2026/03/13 00:00 [received] PHST- 2026/04/17 00:00 [revised] PHST- 2026/04/24 00:00 [accepted] PHST- 2026/06/08 12:39 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 07:18 [entrez] PHST- 2026/05/21 00:00 [pmc-release] AID - 10.3389/fnut.2026.1830074 [doi] PST - epublish SO - Front Nutr. 2026 May 21;13:1830074. doi: 10.3389/fnut.2026.1830074. eCollection 2026. PMID- 42253219 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261020 IS - 1467-1107 (Electronic) IS - 1047-9511 (Print) IS - 1047-9511 (Linking) VI - 36 IP - 6 DP - 2026 Jun TI - Assessment of improvements in exercise tolerance following pulmonary valve replacement using physical accelerometry. PG - 1208-1214 LID - 10.1017/S1047951126113493 [doi] AB - BACKGROUND: Pulmonary valve replacement may be required for patients with pulmonary valve disease. Exertional symptoms related to cardiovascular disease are an indication for pulmonary valve replacement; however, quantification of symptom improvement postoperatively is challenging, and previous studies have yielded mixed data. Accelerometry has the potential to remotely monitor changes in exercise tolerance following pulmonary valve replacement. METHODS: Individuals (n = 18) age >13 years scheduled for catheter-based or surgical pulmonary valve replacement were prospectively enrolled. Participants were instructed to wear two Link GT9X accelerometers, placed on dominant wrist and one ankle, for seven days and nights before pulmonary valve replacement and again 3-6 months after the procedure. RESULTS: The cohort's median age was 26.5 [16.0, 35.0] years old. Compliance of both wrist and ankle accelerometers had a median of 96% or greater at both timepoints suggesting adequate participation. Accelerometry showed stability between participants. Quantitative analysis using pre-and post-pulmonary valve replacement accelerometer-derived measures yielded no significant differences. There was a significant decrease in the average score for items "Shortness of Breath with Strenuous Activity," "Extent Symptoms Impact Daily Activities," and "Challenges with Activities of Daily Living." Furthermore, all 9 individuals with baseline exertional intolerance had resolution of symptom in postoperative assessment. CONCLUSION: Reliability of accelerometer-derived activity measurements supports usage of physical accelerometry as a remote outcome measure to reduce patient burden for onsite assessment. Mixed qualitative versus quantitative improvement in physical activity tolerance observed in this study aligns with previous studies on variable improvement in exercise tolerance following pulmonary valve replacement. This discrepancy suggests the need for a different quantitative mechanism to measure benefit. FAU - Joy, Nicholas AU - Joy N AUID- ORCID: 0009-0005-1400-797X AD - Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, USA. ROR: https://ror.org/05dq2gs74 FAU - Soslow, Jonathan H AU - Soslow JH AUID- ORCID: 0000-0001-9194-5330 AD - Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, USA. ROR: https://ror.org/05dq2gs74 FAU - Crum, Kimberly AU - Crum K AD - Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, USA. ROR: https://ror.org/05dq2gs74 FAU - Killian, Mary AU - Killian M AD - Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, USA. ROR: https://ror.org/05dq2gs74 AD - Division of Pediatric Cardiology, Department of Pediatrics, University of Louisville School of Medicine, USA. FAU - Sunthankar, Sudeep AU - Sunthankar S AUID- ORCID: 0000-0002-2687-8204 AD - Division of Pediatric Cardiology, Department of Pediatrics, Vanderbilt University Medical Center, USA. ROR: https://ror.org/05dq2gs74 LA - eng GR - R01 HL167969/HL/NHLBI NIH HHS/United States GR - P50 HD106446/HD/NICHD NIH HHS/United States GR - R01 FD006649/FD/FDA HHS/United States GR - R56 HL141248/HL/NHLBI NIH HHS/United States GR - K23 HL123938/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260608 PL - England TA - Cardiol Young JT - Cardiology in the young JID - 9200019 SB - IM MH - Humans MH - *Exercise Tolerance/physiology MH - Female MH - Male MH - *Accelerometry/methods MH - *Heart Valve Prosthesis Implantation MH - *Pulmonary Valve/surgery MH - Adult MH - Prospective Studies MH - Adolescent MH - Young Adult PMC - PMC13311448 MID - NIHMS2175068 OTO - NOTNLM OT - accelerometry OT - exercise tolerance OT - pulmonary valve replacement OT - tetralogy of Fallot COIS- Dr Soslow has received a grant from Ametris, LLC. to conduct an observational study, however no associated data was used in development of this manuscript. EDAT- 2026/06/08 12:38 MHDA- 2026/10/20 17:34 PMCR- 2026/06/29 CRDT- 2026/06/08 06:43 PHST- 2026/10/20 17:34 [medline] PHST- 2026/06/08 12:38 [pubmed] PHST- 2026/06/08 06:43 [entrez] PHST- 2026/06/29 00:00 [pmc-release] AID - S1047951126113493 [pii] AID - 10.1017/S1047951126113493 [doi] PST - ppublish SO - Cardiol Young. 2026 Jun;36(6):1208-1214. doi: 10.1017/S1047951126113493. Epub 2026 Jun 8. PMID- 42253056 OWN - NLM STAT- MEDLINE DCOM- 20260608 LR - 20260813 IS - 1918-1523 (Electronic) IS - 1203-6765 (Print) IS - 1203-6765 (Linking) VI - 2026 IP - 1 DP - 2026 TI - Prevalence and Determinants of Neck and Shoulder Pain Among Saudi Adults: A Cross-Sectional Study. PG - e9087950 LID - 10.1155/prm/9087950 [doi] LID - 9087950 AB - BACKGROUND: Neck and/or shoulder pain (NSP) represents a significant public health burden worldwide. However, nationally representative data from Saudi Arabia remain limited as most existing studies have focused on specific occupational groups or localized populations. This study examines the prevalence, determinants, and risk factors of NSP among Saudi adults. MATERIALS AND METHODS: A cross-sectional study was conducted between May and September 2024 among 2171 adults across Saudi Arabia. Data were collected from participants aged >/= 18 years using a structured, validated questionnaire assessing NSP prevalence, sociodemographic characteristics, lifestyle factors, and comorbidities. RESULT: Among 2171 participants (mean age of 29 +/- 12), 54% were females. The overall point prevalence of neck pain was 39.1%, while shoulder pain affected 38.6% of participants. Higher odds of neck pain were associated with use of electronic devices (OR = 1.82, p = 0.003), occupational tasks with extended standing (OR = 1.53, p = 0.003), and history of trauma (OR = 2.52, p < 0.001). Shoulder pain was associated with prolonged use of electronic devices (OR = 2.14, p < 0.001) and history of trauma (OR = 4.77, p < 0.001). Notably, regular exercise and male sex were protective against both neck pain and shoulder pain compared to females. CONCLUSION: NSP is common among Saudi adults and linked to modifiable lifestyle and work-related factors, underscoring the need for prevention, ergonomic measures, and regular pain management. Long-term studies are needed to evaluate its impact and treatment outcomes. CI - Copyright (c) 2026 Mohammad A. Jareebi et al. Pain Research and Management published by John Wiley & Sons Ltd. FAU - Jareebi, Mohammad A AU - Jareebi MA AUID- ORCID: 0000-0002-4525-1191 AD - Department of Family and Community Medicine, College of Medicine, Jazan University, Jazan, Saudi Arabia, jazanu.edu.sa. FAU - Abutaleb, Yazeed Bader AU - Abutaleb YB AUID- ORCID: 0009-0006-7960-9354 AD - Department of Surgery, Faculty of Medicine, Jazan University, Jazan, Saudi Arabia, jazanu.edu.sa. FAU - Aldalbahi, Sultan Sayil Ghazi AU - Aldalbahi SSG AUID- ORCID: 0009-0009-1003-5681 AD - Department of Surgery, Faculty of Medicine, Shaqra University, Dawadmi, Saudi Arabia, su.edu.sa. FAU - Alharfi, Adel Ali AU - Alharfi AA AUID- ORCID: 0009-0002-7038-5519 AD - Department of Surgery, Faculty of Medicine, Tabuk University, Tabuk, Saudi Arabia, ut.edu.sa. FAU - Althobaiti, Faisal Mayudh AU - Althobaiti FM AUID- ORCID: 0009-0005-7379-5224 AD - Department of Surgery, Faculty of Medicine, Tabuk University, Tabuk, Saudi Arabia, ut.edu.sa. FAU - Barnawi, Lama Mohammad AU - Barnawi LM AD - Department of Surgery, Faculty of Medicine, Tabuk University, Tabuk, Saudi Arabia, ut.edu.sa. FAU - Alateeq, Noura Mohammed AU - Alateeq NM AUID- ORCID: 0009-0007-5642-4530 AD - Department of Surgery, Faculty of Medicine, Almaarefa University, Riyadh, Saudi Arabia, um.edu.sa. FAU - Alrabea, Hajer Othman AU - Alrabea HO AD - Department of Surgery, Faculty of Medicine, Almaarefa University, Riyadh, Saudi Arabia, um.edu.sa. FAU - Hakami, Ibrahim A AU - Hakami IA AUID- ORCID: 0000-0002-9795-477X AD - Department of Orthopedic Surgery, Dawadmi College of Medicine, Shaqra University, Shaqra, Saudi Arabia, su.edu.sa. FAU - Ryani, Majed A AU - Ryani MA AUID- ORCID: 0000-0003-1457-3064 AD - Department of Family and Community Medicine, College of Medicine, Jazan University, Jazan, Saudi Arabia, jazanu.edu.sa. FAU - Bahri, Ahmed A AU - Bahri AA AUID- ORCID: 0000-0001-5849-6238 AD - Department of Family and Community Medicine, College of Medicine, Jazan University, Jazan, Saudi Arabia, jazanu.edu.sa. FAU - Maslamani, Yahya A AU - Maslamani YA AUID- ORCID: 0000-0002-7241-7222 AD - Public Health Authority-Southern Sector, Jazan, Saudi Arabia. FAU - Masmali, Ali Abdullah AU - Masmali AA AD - Radiology Department, King Fahd Central Hospital, Jazan, Saudi Arabia. FAU - Aqeeli, Abdulwahab A AU - Aqeeli AA AUID- ORCID: 0000-0003-0841-6724 AD - Department of Family and Community Medicine, College of Medicine, Jazan University, Jazan, Saudi Arabia, jazanu.edu.sa. FAU - Alasmari, Mohammed AU - Alasmari M AUID- ORCID: 0000-0002-5388-7579 AD - Orthopaedic Surgery Department, Majmaah University, Al Majma'ah, Saudi Arabia, mu.edu.sa. LA - eng PT - Journal Article PL - United States TA - Pain Res Manag JT - Pain research & management JID - 9612504 SB - IM MH - Humans MH - Female MH - Saudi Arabia/epidemiology MH - Cross-Sectional Studies MH - *Shoulder Pain/epidemiology MH - Prevalence MH - *Neck Pain/epidemiology MH - Male MH - Risk Factors MH - Adult MH - Young Adult MH - Middle Aged MH - Surveys and Questionnaires MH - Adolescent PMC - PMC13244136 OTO - NOTNLM OT - NSP prevalence OT - Saudi Arabia OT - electronic device use OT - neck pain OT - risk factors OT - shoulder pain COIS- The authors declare no conflicts of interest. EDAT- 2026/06/08 06:35 MHDA- 2026/06/08 19:38 PMCR- 2026/06/08 CRDT- 2026/06/08 05:03 PHST- 2026/03/24 00:00 [revised] PHST- 2025/08/07 00:00 [received] PHST- 2026/05/16 00:00 [accepted] PHST- 2026/06/08 19:38 [medline] PHST- 2026/06/08 06:35 [pubmed] PHST- 2026/06/08 05:03 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - PRM9087950 [pii] AID - 10.1155/prm/9087950 [doi] PST - ppublish SO - Pain Res Manag. 2026;2026(1):e9087950. doi: 10.1155/prm/9087950. PMID- 42252548 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20260819 IS - 1440-1754 (Electronic) IS - 1034-4810 (Print) IS - 1034-4810 (Linking) VI - 62 IP - 8 DP - 2026 Aug TI - Role of Skinfold Thickness and MUAC in Predicting Insulin Resistance: ROC And Regression Analysis. PG - 1482-1488 LID - 10.1111/jpc.70456 [doi] AB - INTRODUCTION: Early detection of insulin resistance (IR) in children is essential to prevent long-term metabolic complications. Simple anthropometric measures-mid-upper arm circumference (MUAC) and skinfold thickness-are widely used, but their predictive value, especially when age-standardized, remains unclear. This study aimed to evaluate the performance of raw, SDS, and percentile MUAC and skinfold measurements in predicting IR in patients with obesity and adolescents. METHODS: A cross-sectional study was conducted with 171 participants with obesity aged 6-18 years. Anthropometric measurements were recorded and converted to SDS and percentile values. Insulin resistance was evaluated using HOMA-IR with pubertal-stage-adjusted cutoffs. Logistic regression and ROC analyses were applied. RESULTS: Insulin resistance was present in 56.1% of participants. Both MUAC and skinfold thickness showed significant positive associations with IR; however, standardized measures (SDS and percentiles) demonstrated markedly stronger predictive value than raw measurements. Skinfold thickness SDS emerged as the strongest independent predictor of IR (OR = 12.04, p < 0.001), followed by MUAC SDS (OR = 7.28, p < 0.001). ROC analysis showed excellent discriminatory power for skinfold SDS (AUC = 0.82), with an optimal cutoff of 1.48 (76% sensitivity, 80% specificity). MUAC SDS also performed well (AUC = 0.76; cutoff = 1.10). CONCLUSION: Skinfold thickness SDS and MUAC SDS are strong, practical, and non-invasive markers for predicting insulin resistance in paediatric patients with obesity. Standardized measurements clearly outperform raw values and should be integrated into routine clinical assessment to enhance early detection of metabolic risk. CI - (c) 2026 Paediatrics and Child Health Division (The Royal Australasian College of Physicians). FAU - Gurcan Kaya, Neslihan AU - Gurcan Kaya N AUID- ORCID: 0000-0002-1813-7780 AD - Depatmament of Pediatric Gastroenterology, Ankara Training and Research Hospital, Ankara, Turkey. FAU - Kinali Cetin, Yasemin AU - Kinali Cetin Y AUID- ORCID: 0009-0000-5604-5759 AD - Depatmament of Pediatric Endocrinology, Ankara Training and Research Hospital, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260607 PL - Australia TA - J Paediatr Child Health JT - Journal of paediatrics and child health JID - 9005421 SB - IM MH - Humans MH - *Insulin Resistance MH - Child MH - *Skinfold Thickness MH - Female MH - Cross-Sectional Studies MH - Male MH - Adolescent MH - ROC Curve MH - Predictive Value of Tests MH - *Anthropometry/methods MH - *Arm/anatomy & histology MH - Regression Analysis MH - *Pediatric Obesity PMC - PMC13480573 OTO - NOTNLM OT - HOMA-IR OT - MUAC OT - anthropometry OT - insulin resistance OT - paediatric obesity OT - skinfold thickness COIS- The authors declare no conflicts of interest. EDAT- 2026/06/08 06:36 MHDA- 2026/08/17 17:45 PMCR- 2026/08/17 CRDT- 2026/06/08 00:22 PHST- 2026/05/04 00:00 [revised] PHST- 2026/03/06 00:00 [received] PHST- 2026/05/25 00:00 [accepted] PHST- 2026/08/17 17:45 [medline] PHST- 2026/06/08 06:36 [pubmed] PHST- 2026/06/08 00:22 [entrez] PHST- 2026/08/17 00:00 [pmc-release] AID - JPC70456 [pii] AID - 10.1111/jpc.70456 [doi] PST - ppublish SO - J Paediatr Child Health. 2026 Aug;62(8):1482-1488. doi: 10.1111/jpc.70456. Epub 2026 Jun 7. PMID- 42252458 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260812 LR - 20260815 IS - 2055-5784 (Print) IS - 2055-5784 (Electronic) IS - 2055-5784 (Linking) VI - 12 IP - 1 DP - 2026 Jun 8 TI - Combining self-regulation and poverty reduction to prevent depression and anxiety among adolescents experiencing multi-dimensional poverty in Colombia, Nepal and South Africa: study protocol of a pilot 4-arm cluster randomised controlled trial. LID - 10.1186/s40814-026-01858-y [doi] LID - 113 AB - BACKGROUND: Poverty is associated with depression and anxiety among adolescents, but evidence of interventions that prevent adolescent depression and anxiety among adolescents living in poverty is weak. Interventions either focus on reducing poverty or addressing depression and anxiety, but an approach that combines both may offer larger benefit. This multi-site parallel pilot cluster randomised controlled trial (cRCT) evaluates the feasibility and acceptability of a selective preventive intervention for depression and anxiety that simultaneously intervenes on both poverty and self-regulation among adolescents living in urban poverty. METHODS: The study takes place in Bogota (Colombia), Kathmandu (Nepal) and Cape Town (South Africa). The pilot cRCT has four arms: (i) self-regulation intervention, (ii) economic intervention, (iii) combined (self-regulation + economic) intervention, and (iv) control group (care as usual). Interventions consist of 20 weekly group sessions with adolescents, and 6 monthly group sessions with their caregivers. The self-regulation intervention for adolescents includes psychological activities (mindfulness breathing, problem solving, biofeedback and goal setting) and a physical activity. The economic intervention includes three dimensions (financial training, negotiation training, education information) and a monthly cash transfer. In each site, the aim was to recruit 240 adolescents and their caregivers across eight schools (clusters), with two schools randomised to each arm. Adolescents residing in areas at risk of multidimensional poverty and who had symptoms of depression or anxiety, but who did not meet thresholds indicating depression and anxiety disorders, were considered for enrolment. Recruitment into the study is complete: a total of 628 adolescents and 536 caregivers were enrolled. Participants will be assessed four times: at enrolment, post-intervention and at 12 and 18 months post-enrolment. Primary outcomes include feasibility and acceptability criteria for study and intervention delivery procedures (i.e. randomisation, masking, recruitment, retention, missingness, fidelity, attendance, adverse events) defined as traffic light criteria to assess progression to an adequately powered trial. Secondary outcomes include self-report instruments, physiological measures and neuropsychological tasks. DISCUSSION: The effectiveness of combining self-regulation and anti-poverty interventions remains untested. This study will establish the feasibility and acceptability of delivering such an intervention, as well as test the trial procedures to inform a future adequately powered trial. TRIAL REGISTRATION: ISRCTN 14601588. Retrospectively registered. Date: 19 May 2024. CI - (c) 2026. The Author(s). FAU - Jordans, Mark J D AU - Jordans MJD AUID- ORCID: 0000-0001-5925-8039 AD - Center for Global Mental Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, 16 De Crespigny Park, London, SE5 8AB, UK. mark.jordans@kcl.ac.uk. FAU - Lund, Crick AU - Lund C AUID- ORCID: 0000-0002-5159-8220 AD - Center for Global Mental Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, 16 De Crespigny Park, London, SE5 8AB, UK. AD - Alan J Flisher Centre for Public Mental Health, University of Cape Town, Department of Psychiatry and Mental Health, Cape Town, South Africa. FAU - Garman, Emily C AU - Garman EC AUID- ORCID: 0000-0002-8128-5997 AD - Alan J Flisher Centre for Public Mental Health, University of Cape Town, Department of Psychiatry and Mental Health, Cape Town, South Africa. FAU - Bonifaz, Manuel Seifert AU - Bonifaz MS AUID- ORCID: 0009-0003-3458-2440 AD - Center for Global Mental Health, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, 16 De Crespigny Park, London, SE5 8AB, UK. FAU - Avendano, Mauricio AU - Avendano M AD - Center for Primary Care and Public Health (Unisante), University of Lausanne, Lausanne, Switzerland. AD - Department of Social and Behavioral Sciences, Harvard School of Public Health, Boston, USA. FAU - Bauer, Annette AU - Bauer A AD - Care Policy and Evaluation Centre, London, School of Economics and Political Science, London, UK. FAU - Dedios Sanguineti, Maria Cecilia AU - Dedios Sanguineti MC AUID- ORCID: 0000-0002-6141-304X AD - School of Government, Universidad de los Andes, Bogota, Colombia. AD - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA. FAU - Eleftheriou, Georgia AU - Eleftheriou G AD - Center for Global Mental Health Equity, George Washington University, Washington, DC, USA. FAU - Evans-Lacko, Sara AU - Evans-Lacko S AD - Care Policy and Evaluation Centre, London, School of Economics and Political Science, London, UK. FAU - Jaramillo, Sandra Garcia AU - Jaramillo SG AD - School of Government, Universidad de los Andes, Bogota, Colombia. FAU - Garcia, Juan Felipe AU - Garcia JF AD - Innovations for Poverty Action (IPA) Colombia, Bogota, Colombia. FAU - Gautam, Kamal AU - Gautam K AD - Transcultural Psychosocial Organization (TPO) Nepal, Baluwatar Kathmandu, Nepal. FAU - Gevonden, Martin AU - Gevonden M AUID- ORCID: 0000-0001-7867-1443 AD - Department of Biological Psychology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. FAU - Jacobs, Roxanne AU - Jacobs R AUID- ORCID: 0000-0002-0922-1286 AD - Alan J Flisher Centre for Public Mental Health, University of Cape Town, Department of Psychiatry and Mental Health, Cape Town, South Africa. FAU - Kohrt, Brandon A AU - Kohrt BA AUID- ORCID: 0000-0002-3829-4820 AD - Center for Global Mental Health Equity, George Washington University, Washington, DC, USA. FAU - Krabbendam, Lydia AU - Krabbendam L AD - Department Clinical Neuro- and Developmental Psychology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. FAU - Luitel, Nagendra P AU - Luitel NP AUID- ORCID: 0000-0002-8291-0205 AD - Center for Global Mental Health Equity, George Washington University, Washington, DC, USA. AD - Transcultural Psychosocial Organization (TPO) Nepal, Baluwatar Kathmandu, Nepal. FAU - van der Merwe, Nicci AU - van der Merwe N AD - Waves for Change, Muizenberg, South Africa. FAU - Piedrahita, Juan Jose Castellanos AU - Piedrahita JJC AUID- ORCID: 0009-0007-9471-2322 AD - War Child Alliance, Bogota, Colombia. FAU - Singh, Rakesh AU - Singh R AUID- ORCID: 0000-0002-0016-6903 AD - Center for Global Mental Health, Institute of Psychiatry Psychology & Neuroscience, King's College London, London, UK. AD - Department of Research, Transcultural Psychosocial Organization (TPO) Nepal, Kathmandu, Nepal. FAU - Sinichi, Mohammadamin AU - Sinichi M AD - Department Clinical Neuro- and Developmental Psychology, Faculty of Behavioural and Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. FAU - Trujillo, Daniela AU - Trujillo D AD - Innovations for Poverty Action (IPA) Colombia, Bogota, Colombia. AD - Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Sorsdahl, Katherine AU - Sorsdahl K AD - Alan J Flisher Centre for Public Mental Health, University of Cape Town, Department of Psychiatry and Mental Health, Cape Town, South Africa. FAU - Roy, Sanchari AU - Roy S AD - Department of Economics, University of Exeter, Exeter, UK. AD - Department of International Development, King's College London, London, UK. FAU - Tol, Wietse A AU - Tol WA AD - Section of Global Health, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. AD - Athena Institute, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. AD - ARQ International, ARQ Psychotrauma Centre, Diemen, the Netherlands. FAU - Rojas, Daniela AU - Rojas D AD - Innovations for Poverty Action (IPA) Colombia, Bogota, Colombia. FAU - Yarrow, Paula AU - Yarrow P AD - Waves for Change, Muizenberg, South Africa. LA - eng GR - WT_/Wellcome Trust/United Kingdom GR - 221940/Z/20/Z/WT_/Wellcome Trust/United Kingdom PT - Journal Article DEP - 20260608 PL - England TA - Pilot Feasibility Stud JT - Pilot and feasibility studies JID - 101676536 PMC - PMC13465900 OTO - NOTNLM OT - Adolescence OT - Anxiety OT - Cash transfer OT - Depression OT - Poverty OT - Prevention OT - Self-regulation COIS- Declarations. Ethics approval and consent to participate: This study received ethics approval on 18 March 2024 from the King's College London's Health Faculty Research Ethics Subcommittee (reference HR/DP-23/24-40543) (rec@kcl.ac.uk; tel: + 44207848 4070/4077/3871). Ethics approval was also obtained by each of the data collection sites' Institutional Review Boards: The Faculty of Health Sciences' Human Research Ethics Committee at the University of Cape Town (South Africa) (reference number HREC315/2022), Innovations for Poverty Action's Institutional Review Board (Colombia) (reference number 4062) and the Ethical Review Board of the Nepal Health Research Council (Nepal) (reference number 1938, protocol reg. no. 167_2024). All participants recruited in the study provided informed written consent/assent to take part in the study and for publication. Approval for any amendments to the study will be sought from all Ethics Committees, and this will be communicated to ISRCTN and the DSMB. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/06/08 00:35 MHDA- 2026/06/08 00:36 PMCR- 2026/06/08 CRDT- 2026/06/07 23:38 PHST- 2024/10/10 00:00 [received] PHST- 2026/05/22 00:00 [accepted] PHST- 2026/06/08 00:36 [medline] PHST- 2026/06/08 00:35 [pubmed] PHST- 2026/06/07 23:38 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - 10.1186/s40814-026-01858-y [pii] AID - 1858 [pii] AID - 10.1186/s40814-026-01858-y [doi] PST - epublish SO - Pilot Feasibility Stud. 2026 Jun 8;12(1):113. doi: 10.1186/s40814-026-01858-y. PMID- 42252390 OWN - NLM STAT- MEDLINE DCOM- 20260812 LR - 20260814 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Jun 8 TI - Construction and validation of interpersonal violence in terms of the hot weather scale for university students. LID - 10.1186/s40359-026-04929-0 [doi] LID - 1179 AB - The development and validation of interpersonal violence in terms of hot weather scale is the goal of the current study. The initial pool of items was developed by reviewing the literature and taking into account the results of semi-structured interviews (inductive & deductive approach). After expert opinion and ensuring content validity, 25 Items were finalized for further analysis. To run an exploratory factor analysis, data were collected from 1,000 university students. EFA revealed a unidimensional factor structure with 16 retained items, explaining 80.2% of the variance. The scale's 0.98 Cronbach's alpha demonstrates a good level of internal consistency. Confirmatory factor analysis confirmed a unidimensional factor structure with 16 items retained on an independent sample of 350 university students. Convergent and divergent validity of the scale was assessed through an independent sample (n = 440). The results showed that there was a strong positive relationship of interpersonal violence in terms of hot weather, with aggression, and a non-significant relationship with eating behavior. The scale can be regarded as a psychometrically reliable tool to assess interpersonal violence in terms of hot weather. CI - (c) 2026. The Author(s). FAU - Ghayas, Saba AU - Ghayas S AD - Department of Psychology, University of Sargodha, Sargodha, Pakistan. saba.ghayas@uos.edu.pk. FAU - Varrasi, Simone AU - Varrasi S AD - Department of Educational Sciences, University of Catania, Via Teatro Greco 84, Catania, 95124, Italy. FAU - Platania, Giuseppe Alessio AU - Platania GA AD - Department of Educational Sciences, University of Catania, Via Teatro Greco 84, Catania, 95124, Italy. FAU - Guerrera, Claudia Savia AU - Guerrera CS AD - Department of Educational Sciences, University of Catania, Via Teatro Greco 84, Catania, 95124, Italy. FAU - Boccaccio, Francesco Maria AU - Boccaccio FM AD - Department of Educational Sciences, University of Catania, Via Teatro Greco 84, Catania, 95124, Italy. FAU - Torre, Vittoria AU - Torre V AD - Department of Educational Sciences, University of Catania, Via Teatro Greco 84, Catania, 95124, Italy. FAU - Pirrone, Concetta AU - Pirrone C AD - Department of Educational Sciences, University of Catania, Via Teatro Greco 84, Catania, 95124, Italy. FAU - Coco, Emanuele AU - Coco E AD - Department of Educational Sciences, University of Catania, Via Teatro Greco 84, Catania, 95124, Italy. FAU - Castellano, Sabrina AU - Castellano S AD - Department of Educational Sciences, University of Catania, Via Teatro Greco 84, Catania, 95124, Italy. FAU - Ferraioli, Francesca AU - Ferraioli F AD - Laboratory of Cognitive and Social Neuroscience, Department of Cognitive Science, Psychology, Education and Cultural Studies (COSPECS), University of Messina, Messina, Italy. FAU - Massimino, Simona AU - Massimino S AD - Laboratory of Cognitive and Social Neuroscience, Department of Cognitive Science, Psychology, Education and Cultural Studies (COSPECS), University of Messina, Messina, Italy. FAU - Mahar, Amama AU - Mahar A AD - Department of Psychology, University of Sargodha, Sargodha, Pakistan. FAU - Akmal, Rashida AU - Akmal R AD - Department of Psychology, University of Sargodha, Sargodha, Pakistan. LA - eng PT - Journal Article PT - Validation Study DEP - 20260608 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - *Psychometrics/instrumentation MH - *Students/psychology MH - Female MH - Universities MH - Reproducibility of Results MH - Young Adult MH - Male MH - *Violence/psychology MH - *Interpersonal Relations MH - Adult MH - Factor Analysis, Statistical MH - *Weather MH - Aggression/psychology MH - Surveys and Questionnaires MH - Adolescent MH - *Hot Temperature PMC - PMC13466488 OTO - NOTNLM OT - Confirmatory factor analysis OT - Exploratory factor analysis OT - Hot weather OT - Interpersonal violence OT - Psychometric properties OT - Scale development COIS- Declarations. Ethics approval and consent to participate: The research process was planned and executed in accordance with the Declaration of Helsinki. Ethical approval was taken from the IRB, University of Sargodha (IRB 22/ 2023). Moreover, the topic was also reviewed by the departmental ethical committee, Department of Educational Science, University of Catania, Italy. Lastly, Written informed consent was taken from participants. Consent for publication: NA. Competing interests: The authors declare no competing interests. EDAT- 2026/06/08 00:35 MHDA- 2026/08/12 06:05 PMCR- 2026/06/08 CRDT- 2026/06/07 23:23 PHST- 2025/10/07 00:00 [received] PHST- 2026/06/01 00:00 [accepted] PHST- 2026/08/12 06:05 [medline] PHST- 2026/06/08 00:35 [pubmed] PHST- 2026/06/07 23:23 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - 10.1186/s40359-026-04929-0 [pii] AID - 4929 [pii] AID - 10.1186/s40359-026-04929-0 [doi] PST - epublish SO - BMC Psychol. 2026 Jun 8;14(1):1179. doi: 10.1186/s40359-026-04929-0. PMID- 42251767 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20261001 IS - 1935-5548 (Electronic) IS - 0149-5992 (Print) IS - 0149-5992 (Linking) VI - 49 IP - 10 DP - 2026 Oct 1 TI - Early Pregnancy Glycemic Testing for Prediction of Gestational Diabetes Mellitus and Large-for-Gestational-Age Birth Weight. PG - 1779-1789 LID - 10.2337/dc26-0302 [doi] AB - OBJECTIVE: We evaluated whether early pregnancy oral glucose tolerance testing (OGTT) or continuous glucose monitoring (CGM) improves gestational diabetes mellitus (GDM) or large-for-gestational-age (LGA) birth prediction over clinical factors alone. RESEARCH DESIGN AND METHODS: In the Glycemic Observation and Metabolic Outcomes in Mothers and Offspring (GO MOMs) study, a prospective observational study at nine U.S. sites (2021-2025), participants with singleton gestation and without preexisting diabetes underwent blinded 75-g OGTT and CGM at 10-14 weeks' gestation. Predictive models for GDM at 24-28 weeks and LGA were developed using these data and clinical factors (maternal age, BMI, GDM or macrosomia history). New glycemic criteria maximized the area under the receiver operating characteristic curve in training data from four sites and were validated in five. Models incorporating OGTT or CGM criteria versus clinical factors alone compared positive predictive value (PPV) at a prespecified negative predictive value (NPV) at a reported 8.3% national GDM prevalence and 10% for LGA. RESULTS: Of 2,178 participants, 93.3% who were pregnant at 24-28 weeks completed OGTTs (15.4% GDM), and 98.1% with live births had data to determine LGA (11.2% LGA). At NPV >/=96% and 8.3% GDM prevalence, PPV for GDM was 12.2% (95% CI 11.0-13.3%) for clinical factors alone, 26.5% (23.1-30.3%) for OGTT plus clinical factors, and 19.8% (17.2-22.5%) for CGM plus clinical factors. For LGA, neither glycemic model improved PPV. Validation confirmed findings. CONCLUSIONS: In a U.S.-representative population, adding 10- to 14-week OGTT or CGM criteria to clinical factors improved GDM but not LGA prediction. Future studies should determine whether predicting GDM in the first trimester facilitates interventions that improve GDM-related pregnancy outcomes. CI - (c) 2026 by the American Diabetes Association. CN - GO MOMs Study Group* LA - eng GR - U01 DK123783/DK/NIDDK NIH HHS/United States GR - U01 DK123759/DK/NIDDK NIH HHS/United States GR - U01 DK123745/DK/NIDDK NIH HHS/United States GR - U01DK123795/DK/NIDDK NIH HHS/United States GR - U01DK123791/DK/NIDDK NIH HHS/United States GR - U01DK123745/DK/NIDDK NIH HHS/United States GR - U01 DK123799/DK/NIDDK NIH HHS/United States GR - U01 DK123795/DK/NIDDK NIH HHS/United States GR - U01 DK123791/DK/NIDDK NIH HHS/United States GR - U01DK123783/DK/NIDDK NIH HHS/United States GR - U01DK123759/DK/NIDDK NIH HHS/United States GR - U01DK123799/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Observational Study PL - United States TA - Diabetes Care JT - Diabetes care JID - 7805975 RN - 0 (Blood Glucose) SB - IM CIN - Diabetes Care. 2026 Oct 1;49(10):1768-1770. doi: 10.2337/dci26-0079. PMID: 42766766 MH - Humans MH - Female MH - Pregnancy MH - *Diabetes, Gestational/diagnosis/blood MH - Infant, Large for Gestational Age MH - Glucose Tolerance Test MH - Adult MH - Continuous Glucose Monitoring MH - Blood Glucose/metabolism MH - Prospective Studies MH - *Birth Weight/physiology MH - Infant, Newborn PMC - PMC13594796 COIS- Duality of Interest. C.E.P. reported receiving speaker fees and honoraria from Mediflix and Medscape, speaker fees from the Endocrine Society, royalties from Wolters Kluwer/UpToDate, honoraria from the American Diabetes Association, and research funding to her institution from Dexcom. No other potential conflicts of interest relevant to this article were reported. FIR - Scholtens, Denise IR - Scholtens D FIR - Siddique, Juned IR - Siddique J FIR - Bustamante, Patricia IR - Bustamante P FIR - Cheung, Ying Jennifer IR - Cheung YJ FIR - Grott, Tania IR - Grott T FIR - Kuang, Alan IR - Kuang A FIR - Banker, Margaret IR - Banker M FIR - Tull, Mary Beth IR - Tull MB FIR - Guachichullca, Jessica IR - Guachichullca J EDAT- 2026/06/07 18:43 MHDA- 2026/09/21 17:47 PMCR- 2026/06/07 CRDT- 2026/06/07 17:33 PHST- 2026/02/06 00:00 [received] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/09/21 17:47 [medline] PHST- 2026/06/07 18:43 [pubmed] PHST- 2026/06/07 17:33 [entrez] PHST- 2026/06/07 00:00 [pmc-release] AID - 170064 [pii] AID - 260302 [pii] AID - 10.2337/dc26-0302 [doi] PST - ppublish SO - Diabetes Care. 2026 Oct 1;49(10):1779-1789. doi: 10.2337/dc26-0302. PMID- 42251728 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260813 IS - 2057-4347 (Electronic) IS - 2057-4347 (Linking) VI - 12 IP - 3 DP - 2026 Jun TI - Applying Automated Artificial Intelligence Models on Lateral Cephalometric Parameters to Accurately Classify Arab Orthodontic Patient Patterns. PG - e70372 LID - 10.1002/cre2.70372 [doi] LID - e70372 AB - OBJECTIVES: Malocclusion and the treatment process can affect the person's quality of life, which includes physical and psychological effects. Classifying the patient accurately is critical to achieving the desired output. This study aimed to improve the current diagnostic process with artificial-intelligence algorithms using the lateral cephalogram. MATERIALS AND METHODS: The study sample consisted of 1014 Arab patients diagnosed with skeletal class I, II, or III. In this study, we used linear discriminant analysis (LDA), random forest (RF), decision tree (DT), K-nearest neighbors (KNN), support vector machine (SVM), and naive Bayes (NB) as classification models. In addition, we calculated the parameters' importance using two techniques-the impurity decreases and the leave-one-feature-out (LOFO) technique. Finally, we applied an artificial neural network (ANN) to classify the patients accurately. RESULTS: One of the influential models presented in this study was the model that included only the parameters Wits appraisal, SNB, SNA, and ML-NSL angles. It could classify the patients with an accuracy of 0.98. In addition, we applied the leave-one-feature-out technique (LOFO) for multiple random forest models and found that the Calculated_ANB (ANB angle-individualized ANB) and Wits appraisal were the most important parameters in the random forest models. Besides, age and gender were in 8th and 21st places (out of 26 variables). Furthermore, the decision tree results demonstrated the distinct characteristics of this ethnic group, which were presented by different ranges of ANB angles that define every skeletal class. The results showed that the tree's root classified the patient as skeletal class III when the ANB angle is less than 0.084 degrees, and skeletal class II if the ANB angle is greater than 1.23. CONCLUSIONS: In summary, this research presented a model enabling orthodontists to precisely classify orthodontic patients. Further research should include different ethnic groups to validate our findings. CI - (c) 2026 The Author(s). Clinical and Experimental Dental Research published by John Wiley & Sons Ltd. FAU - Midlej, Kareem AU - Midlej K AD - Department of Clinical Microbiology and Immunology, Gray Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Proff, Peter AU - Proff P AD - Department of Orthodontics, University Hospital of Regensburg, University of Regensburg, Regensburg, Germany. FAU - Watted, Nezar AU - Watted N AD - Center for Dentistry Research and Aesthetics, Jatt, Israel. AD - Department of Orthodontics, Faculty of Dentistry, Arab American University, Jenin, Palestine. FAU - Iraqi, Fuad A AU - Iraqi FA AUID- ORCID: 0000-0001-5525-206X AD - Department of Clinical Microbiology and Immunology, Gray Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel. AD - Department of Orthodontics, University Hospital of Regensburg, University of Regensburg, Regensburg, Germany. LA - eng GR - Tel Aviv University, Israel/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Clin Exp Dent Res JT - Clinical and experimental dental research JID - 101692332 SB - IM MH - Humans MH - *Cephalometry/methods MH - Female MH - *Malocclusion/diagnosis/classification MH - Random Forest MH - Male MH - Classification Algorithms MH - Arabs MH - Decision Trees MH - *Artificial Intelligence MH - Discriminant Analysis MH - Neural Networks, Computer MH - Adolescent MH - Bayes Theorem MH - Support Vector Machine MH - Child MH - Algorithms PMC - PMC13242863 OTO - NOTNLM OT - cephalometric parameters OT - deep-learning OT - diagnosis OT - machine-learning OT - personalized medicine OT - skeletal malocclusion COIS- The authors declare no conflicts of interest. EDAT- 2026/06/07 18:41 MHDA- 2026/06/11 06:37 PMCR- 2026/06/07 CRDT- 2026/06/07 14:22 PHST- 2026/03/26 00:00 [revised] PHST- 2025/11/17 00:00 [received] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/06/11 06:37 [medline] PHST- 2026/06/07 18:41 [pubmed] PHST- 2026/06/07 14:22 [entrez] PHST- 2026/06/07 00:00 [pmc-release] AID - CRE270372 [pii] AID - 10.1002/cre2.70372 [doi] PST - ppublish SO - Clin Exp Dent Res. 2026 Jun;12(3):e70372. doi: 10.1002/cre2.70372. PMID- 42251514 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260611 IS - 0975-4466 (Electronic) IS - 0256-4947 (Linking) VI - 46 IP - 3 DP - 2026 May-Jun TI - Establishment and validation of reference intervals for the neutrophil CD64 index in a healthy adult population from Guangxi, China. PG - 216-224 LID - 10.5144/0256-4947.2026.216 [doi] AB - BACKGROUND: The neutrophil CD64 (nCD64) index is a potent biomarker for infectious diseases; however, the lack of standardized reference intervals (RIs) limits its clinical utility. OBJECTIVES: This study aimed to establish and validate reference intervals (RIs) for the nCD64 index specifically for the Guangxi population using flow cytometry. DESIGN: Cross-sectional study. SETTINGS: Conducted in Guangxi, China. PATIENTS AND METHODS: A total of 494 healthy adults (aged 18-83 years) were enrolled. Peripheral blood nCD64 expression was measured via flow cytometry. Reference intervals were determined using the non-parametric 95th percentile method (2.5th-97.5th) per CLSI EP28-A3c guidelines. Validation was performed in an independent cohort (n=30). MAIN OUTCOME MEASURES: The primary outcome was the 95% reference interval for the nCD64 index. Secondary outcomes included correlations between nCD64 index and sex, age, BMI, and primary hematological parameters. SAMPLE SIZE: 494 healthy adults for establishment, plus 30 independent subjects for validation. RESULTS: No clinically significant differences in the nCD64 index were found between sexes or across age groups, and partitioning was not required. The nCD64 index exhibited a skewed distribution. Although sex showed a weak positive correlation with nCD64 expression (r=.115, P=.011), the standard normal deviation test (z/= 2) posture saw a 1.76 +/- 2.9 mm and 3.29 +/- 6.5 mm decrease in RMS and MaxDev, respectively. In contrast, RMS and MaxDev increased by 1.03 +/- 3.0 mm and 1.26 +/- 5.6 mm, respectively, among individuals who stated that their posture had deteriorated or not changed (GRC < 2). Using ROC analysis, MCICs for RMS and MaxDev were determined to be -0.27 mm (area under the curve (AUC) 0.746, sensitivity 67%, specificity 74%) and - 0.49 mm (AUC 0.717, sensitivity 64%, specificity 68%), respectively, for overall improvement perception. Having met both thresholds reduced sensitivity to 62% and achieved 74% specificity. MCICs for thoracic curve types were - 0.58 mm (AUC 0.618, sensitivity 60%, specificity 53%) for RMS and - 1.32 mm (AUC 0.632, sensitivity 73%, specificity 92%) for MaxDev. MCICs for lumbar curve types were - 0.26 mm for RMS (AUC 0.881, sensitivity 73%, specificity 92%) and - 0.61 mm for MaxDev (AUC 0.811, sensitivity 68%, specificity 83%). CONCLUSION: Changes in RMS and MaxDev were aligned to GRC score reflecting perceived improvements in back condition. Stronger associations were observed between ST parameters and perceived improvement in lumbar than thoracic or combining all curves. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Mohamed, Nada AU - Mohamed N AD - Department of Mechanical Engineering, University of Alberta, Edmonton, Canada. FAU - Gonzalez Ruiz, Jose Maria AU - Gonzalez Ruiz JM AD - Department of Mechanical Engineering, University of Alberta, Edmonton, Canada. josemar1@ualberta.ca. AD - 3D-Data Department, Society for the Advancement of Applied Computer Science, Berlin, Germany. josemar1@ualberta.ca. FAU - Schreiber, Sanja AU - Schreiber S AD - Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada. FAU - Parent, Eric AU - Parent E AD - Department of Physical Therapy, Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada. FAU - Mei, Qipei AU - Mei Q AD - Department of Civil and Environmental Engineering, University of Alberta, Edmonton, Canada. FAU - Westover, Lindsey AU - Westover L AD - Department of Mechanical Engineering, University of Alberta, Edmonton, Canada. LA - eng PT - Journal Article DEP - 20260606 PL - Germany TA - Eur Spine J JT - European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society JID - 9301980 SB - IM OTO - NOTNLM OT - Adolescent idiopathic scoliosis OT - Patient-reported outcome measures OT - Postural asymmetry OT - Schroth exercises OT - Surface topography COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/06/06 12:34 MHDA- 2026/06/06 12:34 CRDT- 2026/06/06 11:03 PHST- 2025/10/24 00:00 [received] PHST- 2026/06/02 00:00 [accepted] PHST- 2026/05/29 00:00 [revised] PHST- 2026/06/06 12:34 [medline] PHST- 2026/06/06 12:34 [pubmed] PHST- 2026/06/06 11:03 [entrez] AID - 10.1007/s00586-026-10071-7 [pii] AID - 10.1007/s00586-026-10071-7 [doi] PST - aheadofprint SO - Eur Spine J. 2026 Jun 6. doi: 10.1007/s00586-026-10071-7. PMID- 42249465 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260902 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 27 IP - 1 DP - 2026 Jun 5 TI - Remote, bivariate prior elicitation for a Bayesian non-inferiority randomized controlled trial. LID - 10.1186/s13063-026-09828-8 [doi] LID - 520 AB - BACKGROUND: Prior distributions must be specified for the parameters of interest in a Bayesian clinical trial. When existing evidence on the effects of the trial interventions is limited or inconclusive, prior distributions can be constructed with expert elicitation. However, conventional elicitation requires face-to-face interactions and intensive pre-elicitation training, which can be infeasible and costly. Our remote elicitation was based on an established expert elicitation methodology, and we incorporated bivariate prior distributions to introduce dependencies between the elicited probabilities. We aimed to elicit a prior distribution for the Croup Dosing Trial, which assesses the efficacy of two separate doses of dexamethasone on the number of return visits to the emergency department within 7 days in children with croup. This trial evaluates the non-inferiority of 0.15 mg/kg of dexamethasone, compared to the standard dose of 0.60 mg/kg to treat croup. METHODS: We conducted three remote workshops to elicit expert beliefs on the efficacy of the two doses of dexamethasone. Each workshop consisted of two survey rounds, separated by a group discussion. Prior to the workshop, experts reviewed the same current literature that was provided on the effects of the two doses of dexamethasone. Beliefs were aggregated using expert-specific bivariate distributions with latent effects. The aggregated distribution, along with the surveyed non-inferiority margin, determined the sample size for the Bayesian non-inferiority trial design. RESULTS: Twelve emergency medicine physicians participated in our remote elicitation exercise. The elicitation generated a prior distribution centered at 6% for the 0.60 mg/kg dose and 8% for the 0.15 mg/kg dose. The aggregated prior distribution produced a sample size of 1850, based on a non-inferiority margin of 4%. CONCLUSIONS: We elicited a prior distribution that incorporated past evidence and expert opinion. The elicited prior is consistent with previous literature on the efficacy of the dexamethasone doses in treating croup. Our approach demonstrates the feasibility of remotely eliciting bivariate distributions to design clinical trials. TRIAL REGISTRATION: NCT06272383 (Registered May 8, 2024). CI - (c) 2026. The Author(s). FAU - Jiang, Arlene AU - Jiang A AUID- ORCID: 0009-0000-3158-8650 AD - Child Health Evaluative Sciences, The Hospital for Sick Children, 686 Bay Street, Toronto, ON, M5G 0A4, Canada. arlene.jiang@sickkids.ca. FAU - Aregbesola, Alex AU - Aregbesola A AD - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. AD - Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. FAU - Gangwani, Apoorva AU - Gangwani A AD - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. FAU - Klassen, Terry P AU - Klassen TP AD - College of Medicine, University of Saskatchewan and Jim Pattison Children's Hospital, Saskatchewan Health Authority, Saskatoon, SK, Canada. FAU - Plint, Amy C AU - Plint AC AD - Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada. AD - Division of Emergency Medicine, Children's Hospital of Eastern Ontario, Ottawa, ON, Canada. FAU - Doyle, Elisabete AU - Doyle E AD - Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. FAU - Craig, William AU - Craig W AD - Department of Medicine and Dentistry, University of Alberta, Edmonton, AB, Canada. FAU - Eltorki, Mohamed AU - Eltorki M AD - Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. FAU - Oketola, Banke AU - Oketola B AD - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. FAU - Badran, Hoda AU - Badran H AD - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. AD - Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. FAU - Ouyang, Yongdong AU - Ouyang Y AD - Department of Biostatistics and Bioinformatics, Roswell Park Comprehensive Cancer Center, Buffalo, NY, USA. FAU - Heath, Anna AU - Heath A AD - Child Health Evaluative Sciences, The Hospital for Sick Children, 686 Bay Street, Toronto, ON, M5G 0A4, Canada. AD - Division of Biostatistics, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. AD - Department of Statistical Science, University College London, London, UK. LA - eng SI - ClinicalTrials.gov/NCT06272383 GR - RGPIN-2021-03366/Canada Research Chairs/ GR - 2024 New Investigator Operating Grant #6456/Research Manitoba/ PT - Clinical Trial, Phase III PT - Equivalence Trial PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20260605 PL - England TA - Trials JT - Trials JID - 101263253 RN - 7S5I7G3JQL (Dexamethasone) RN - 0 (Glucocorticoids) SB - IM MH - Child MH - Humans MH - Bayes Theorem MH - *Croup/drug therapy/diagnosis MH - *Dexamethasone/administration & dosage/adverse effects MH - Emergency Service, Hospital MH - *Glucocorticoids/administration & dosage/adverse effects MH - *Research Design MH - Time Factors MH - Treatment Outcome PMC - PMC13459373 OTO - NOTNLM OT - Bayesian statistics OT - Expert elicitation OT - Non-inferiority trial OT - Prior probability distribution OT - Randomized controlled trials OT - Sample size determination OT - Trial design COIS- Declarations. Ethics approval and consent to participate: The elicitation of the Croup Dosing Trial has ethics approval from Health Canada (# CDS0923) as well as University of Manitoba Health Research Ethics Board & Shared Health (# HS26166 (B2023:092)) approval. The Hospital for Sick Children Research Ethics Board approved a secondary use of the elicitation data (# 1000081720). Implied consent was used in this study. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/06/06 00:35 MHDA- 2026/08/11 06:36 PMCR- 2026/06/05 CRDT- 2026/06/05 23:38 PHST- 2024/11/15 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/08/11 06:36 [medline] PHST- 2026/06/06 00:35 [pubmed] PHST- 2026/06/05 23:38 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - 10.1186/s13063-026-09828-8 [pii] AID - 9828 [pii] AID - 10.1186/s13063-026-09828-8 [doi] PST - epublish SO - Trials. 2026 Jun 5;27(1):520. doi: 10.1186/s13063-026-09828-8. PMID- 42248933 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20260820 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 5 TI - Evaluating chest-worn light logger adherence: development and application of a wear/non-wear model. LID - 10.1038/s41598-026-54493-1 [doi] LID - 25733 AB - Light exposure plays an important role in overall health because it entrains circadian rhythms. Recent technological advances in wearable light loggers allow measurement daily light exposure habits. Using a chest-worn light logger, our goal was to (1) develop methodology for differentiating adherent versus non-adherent use, and (2) define differences in lighting intensity in indoor and outdoor environments, to improve data reliability in future clinical studies using this technology. Four testers used a 10-channel chest worn light logging device under different conditions of wear and non-wear (experiment 1), and another tester made measurements with the light logger across a variety of indoor and outdoor lighting environments (experiment 2). In experiment 1, measurements from the light logger (photopic illuminance, device orientation, accelerometer data, time of day) were used to train models to differentiate wear from non-wear and correct nighttime placement. The most accurate model was then tested with the remaining data from testers (T1 - T4). This model was then applied to 20 adolescents and young adults with migraine who wore the light logger device for one week. In experiment 2, measurements of photopic illuminance and melanopic equivalent daytime illuminance (mEDI) of darker indoor versus brighter outdoor lighting environments were compared to identify the optimal indoor/outdoor distinction point for the chest-worn light logger. Movement, device orientation, light, and time-of-day used as predictors in a random forest model had excellent differentiation between wear, non-wear and nighttime use (overall accuracy 0.95), and retained good-to-excellent differentiation when applied to the test dataset (overall accuracy 0.76). When this model was applied to 20 participants with migraine, we found that 92.1% of participant-days and 77.9% of participant-nights demonstrated at least 80% appropriate use. Applying the wear/non-wear model to this dataset led to modest changes in light exposure measurements but did not change conclusions of our prior study. For differentiating indoor and outdoor lighting environments, the optimal cut-point was 442 lx for photopic illuminance, and 412 lx for mEDI. We demonstrate that internal measurements from a chest-worn light logging device can reliably differentiate wear from non-wear. We also found that the optimal cut-off to differentiate indoor and outdoor lighting environments was lower than 1,000 lx cut-offs traditionally used to define bright light conditions. These findings can be used to improve data reliability in studies of everyday light exposure in clinical populations using chest-worn light loggers. CI - (c) 2026. The Author(s). FAU - Patterson Gentile, Carlyn AU - Patterson Gentile C AD - Children's Hospital of Philadelphia, Philadelphia, PA, USA. pattersonc@chop.edu. AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. pattersonc@chop.edu. FAU - Thomas, Adah AU - Thomas A AD - Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Shah, Ryan AU - Shah R AD - Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA. FAU - Marquez De Prado, Blanca AU - Marquez De Prado B AD - Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Raj, Nichelle AU - Raj N AD - Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Szperka, Christina L AU - Szperka CL AD - Children's Hospital of Philadelphia, Philadelphia, PA, USA. AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. FAU - Aguirre, Geoffrey K AU - Aguirre GK AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. LA - eng GR - K23 NS124986/NS/NINDS NIH HHS/United States GR - R25 HD101365/HD/NICHD NIH HHS/United States GR - Foerderer/Children's Hospital of Philadelphia/ GR - R01EY036255/EY/NEI NIH HHS/United States GR - R25HD101365/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ GR - R01 EY036255/EY/NEI NIH HHS/United States GR - K23NS124986/NS/NINDS NIH HHS/United States PT - Journal Article DEP - 20260605 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM UOF - medRxiv. 2025 Sep 30:2025.09.29.25336898. doi: 10.1101/2025.09.29.25336898. PMID: 41256166 MH - Humans MH - *Lighting MH - Adolescent MH - *Light MH - Circadian Rhythm/physiology MH - *Wearable Electronic Devices MH - Male MH - Young Adult MH - Female MH - *Patient Compliance MH - Adult PMC - PMC13482094 OTO - NOTNLM OT - Continuous light measurements OT - Daily light exposure OT - Data reliability OT - Melanopic equivalent daylight illuminance OT - Photopic illuminance COIS- Declarations. Conflict of interest: Commercial Relationships Disclosures: C.P.G.: Dr. Patterson Gentile is currently funded by the National Institutes of Health/National Institute of Neurological Disorders and Stroke (K23 NS124986). C.L.S.: Dr. Szperka has received research/grant support from the PCORI. Dr. Szperka or her institution have received compensation for her consulting work for Eli Lilly; Teva Pharmaceutical Industries Ltd; Upsher-Smith Laboratories, LLC; Abbvie; and Lundbeck. Dr. Szperka has intellectual property as the inventor of the text-based headache diary used in the study. She did not receive any financial compensation related to this paper. G.K.A.: Dr. Aguirre receives funding/grant support from the National Institute of Neurological Disorders and Stroke, the National Eye Institute, and the Binational Science Foundation. A.T., R.S., B.M.P., and N.R. do not have conflicts of interest. EDAT- 2026/06/06 00:35 MHDA- 2026/08/18 07:46 PMCR- 2026/06/05 CRDT- 2026/06/05 23:17 PHST- 2025/10/07 00:00 [received] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/08/18 07:46 [medline] PHST- 2026/06/06 00:35 [pubmed] PHST- 2026/06/05 23:17 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - 10.1038/s41598-026-54493-1 [pii] AID - 54493 [pii] AID - 10.1038/s41598-026-54493-1 [doi] PST - epublish SO - Sci Rep. 2026 Jun 5;16(1):25733. doi: 10.1038/s41598-026-54493-1. PMID- 42247777 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1878-0539 (Electronic) IS - 1748-6815 (Linking) VI - 118 DP - 2026 Jul TI - Quantitative preliminary indication criteria and clinical outcomes of Abbe Flap repair for secondary cleft lip deformities. PG - 313-324 LID - S1748-6815(26)00316-5 [pii] LID - 10.1016/j.bjps.2026.05.050 [doi] AB - OBJECTIVE: Secondary nasolabial deformities are common after primary cleft lip repair, yet objective preliminary quantitative indication criteria for Abbe flap repair remain lacking. This study aimed to establish preliminary quantitative indication thresholds for Abbe flap repair, evaluate its clinical efficacy, and explore preoperative predictors for optimal postoperative outcomes. METHODS: This STROBE-compliant retrospective cohort study enrolled 102 patients with secondary cleft lip deformities (21 in Abbe flap group, 81 in non-Abbe flap group) and 36 healthy controls. Standardized anthropometric measurements, phenotypic stratification via cluster analysis, and ROC curve analysis for diagnostic efficacy were conducted. RESULTS: The Abbe flap group showed significant postoperative improvements in all core morphological parameters (all P < 0.05), while conventional non-Abbe repair yielded minimal improvement in patients with significant upper lip tissue deficiency. The optimal preliminary cut-off values for Abbe flap indication were upper-to-lower lip projection ratio (ULR) /=108 degrees (sensitivity 95.24%, specificity 93.15%). Stratified analysis confirmed the therapeutic superiority of Abbe flap was independent of initial cleft type, and preoperative lip height index (LHI) and intercanthal width to medial upper lip height ratio (IMWH) were independent predictors for optimal postoperative outcomes. CONCLUSION: Preoperative ULR /=108 degrees can be used as preliminary objective quantitative reference criteria for Abbe flap selection in secondary cleft lip deformity patients, with prospective multi-center validation required for further clinical generalization. The Abbe flap can achieve significant correction of morphological abnormalities caused by upper lip tissue deficiency, and preoperative LHI and IMWH can assist in prognostic evaluation for surgical candidates. CI - Copyright (c) 2026 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved. FAU - He, Wen AU - He W AD - Department of Burn and Plastic Surgery, Children's Hospital of Chongqing Medical University, No. 136 Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China. Electronic address: 1738591282@qq.com. FAU - Qiu, Lin AU - Qiu L AD - Department of Burn and Plastic Surgery, Children's Hospital of Chongqing Medical University, No. 136 Zhongshan 2nd Road, Yuzhong District, Chongqing 400014, China. LA - eng PT - Journal Article DEP - 20260529 PL - Netherlands TA - J Plast Reconstr Aesthet Surg JT - Journal of plastic, reconstructive & aesthetic surgery : JPRAS JID - 101264239 SB - IM MH - Humans MH - *Cleft Lip/surgery MH - *Surgical Flaps MH - Female MH - Retrospective Studies MH - Male MH - Treatment Outcome MH - *Plastic Surgery Procedures/methods MH - Child MH - Child, Preschool MH - Lip/surgery MH - Adolescent MH - Infant OTO - NOTNLM OT - Abbe flap OT - Anthropometric measurement OT - Quantitative indication OT - Secondary cleft lip deformity OT - Surgical outcome COIS- Declaration of Competing Interest None declared. EDAT- 2026/06/06 00:34 MHDA- 2026/06/27 00:53 CRDT- 2026/06/05 18:03 PHST- 2026/04/01 00:00 [received] PHST- 2026/05/24 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/06/27 00:53 [medline] PHST- 2026/06/06 00:34 [pubmed] PHST- 2026/06/05 18:03 [entrez] AID - S1748-6815(26)00316-5 [pii] AID - 10.1016/j.bjps.2026.05.050 [doi] PST - ppublish SO - J Plast Reconstr Aesthet Surg. 2026 Jul;118:313-324. doi: 10.1016/j.bjps.2026.05.050. Epub 2026 May 29. PMID- 42247677 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260911 IS - 2291-5222 (Electronic) IS - 2291-5222 (Linking) VI - 14 DP - 2026 Jun 5 TI - Automated Physical Activity Support for Adults and Youth From Low-Income Communities: Single-Arm Pilot Study. PG - e76991 LID - 10.2196/76991 [doi] LID - e76991 AB - BACKGROUND: Mobile health (mHealth) interventions are growing in popularity, but less research has focused on low-income families, particularly interventions integrating wearable devices with automated personalized messages. OBJECTIVE: We tested a preliminary wearable-integrated mHealth intervention with initial personalization elements among adults and youth from low-income urban communities, focusing on feasibility, acceptability, and preliminary evidence of physical activity behavior. METHODS: Participants were 83 adults and 31 youth recruited through community health events held in low-income urban communities. Using a single-arm pre-post design, participants were enrolled into a 7-week beta-version mHealth intervention that integrated a Garmin activity monitor with automated text messages. Messages were sent 4 days/week and focused on increasing step counts using theory-based behavior change techniques related to goal setting, self-monitoring, reinforcement, contextual factors, and self-efficacy. Most messages were personalized by including calculations based on the step-count and step-goal data, using branching logic, and using 2-way question-and-response messages. Feasibility measures included enrollment, retention, fidelity of message delivery, and adherence to wearing the Garmin device. Acceptability measures included survey items and engagement with responding to 2-way messages. Changes in daily steps were explored using mixed-effects linear regression. RESULTS: Enrollment and eligibility rates were 64% (84/132, adults) and 63% (31/49, youth), retention for physical activity measures was 84% (70/83) and 77% (24/31), and 99% (3910/3955) of the intended messages were delivered. Adults and youth adhered to wearing the Garmin on 82% (45/56) and 79% (44/56) of the study days, respectively. Overall acceptability ratings were 83% to 100%, with 97% (75/77) of adults and 100% (27/27) of youth indicating they would recommend the program. Adults and youth replied to a mean of 2.6 (SD 2.2) and 3.2 (SD 2.7) of the 7 text messages that asked for a reply, with higher engagement among adults who participated with their child. Pre-post changes in daily steps were beta=240 (95% CI -387 to 866) for adults and beta=413 (95% CI -877 to 1703) among youth, with larger changes observed among those in the highest tertile of engagement (adults: beta=584, 95% CI -784 to 1952; n=19; youth: beta=941, 95% CI -827 to 2709; n=11) and those who were meeting less than two-thirds of the physical activity guideline at baseline (adults: beta=609, 95% CI -30 to 1247; n=47; youth: beta=1406, 95% CI -94 to 2907; n=22). CONCLUSIONS: Personalized mHealth physical activity interventions integrating wearable step trackers with automated text messaging appear to be feasible and acceptable among adults and youth from low-income communities. Step-count findings show promise for the intervention's ability to support individuals who are further from meeting physical activity guidelines and warrant more research among parent-child dyads. Overall, findings support additional research to optimize and evaluate similar interventions within this population group using fully powered randomized controlled trials. TRIAL REGISTRATION: ClinicalTrials.gov NCT05110508; https://clinicaltrials.gov/ct2/show/NCT05110508. CI - (c)Jordan A Carlson, Frank Materia, Mallory Moon, Suryeon Ryu, Cory Yeager, Chelsea Steel, Kacee Shields, Harpreet Singh Gill, Jannette Berkley-Patton, Delwyn Catley. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org), 05.06.2026. FAU - Carlson, Jordan A AU - Carlson JA AUID- ORCID: 0000-0002-6008-7983 AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Hospital, Kansas City, MO, United States. FAU - Materia, Frank AU - Materia F AUID- ORCID: 0000-0002-8015-1743 AD - Department of Otolaryngology-Head and Neck Surgery, University of Kansas Medical Center, Kansas City, KS, United States. AD - Department of Population Health, University of Kansas Medical Center, Kansas City, KS, United States. FAU - Moon, Mallory AU - Moon M AUID- ORCID: 0009-0008-3332-7049 AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Hospital, Kansas City, MO, United States. FAU - Ryu, Suryeon AU - Ryu S AUID- ORCID: 0000-0002-8080-8821 AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Hospital, Kansas City, MO, United States. FAU - Yeager, Cory AU - Yeager C AUID- ORCID: 0009-0005-9273-9519 AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Hospital, Kansas City, MO, United States. FAU - Steel, Chelsea AU - Steel C AUID- ORCID: 0000-0002-7119-5840 AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Hospital, Kansas City, MO, United States. FAU - Shields, Kacee AU - Shields K AUID- ORCID: 0009-0006-9302-3093 AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy Hospital, Kansas City, MO, United States. FAU - Gill, Harpreet Singh AU - Gill HS AUID- ORCID: 0009-0001-9512-7615 AD - Research Informatics, Children's Mercy Hospital, Kansas City, MO, United States. FAU - Berkley-Patton, Jannette AU - Berkley-Patton J AUID- ORCID: 0000-0003-0235-7057 AD - Department of Biomedical and Health Informatics, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, United States. FAU - Catley, Delwyn AU - Catley D AUID- ORCID: 0000-0002-7270-8732 AD - Department of Psychology, San Diego State University, San Diego, CA, United States. LA - eng SI - ClinicalTrials.gov/NCT05110508 PT - Journal Article DEP - 20260605 PL - Canada TA - JMIR Mhealth Uhealth JT - JMIR mHealth and uHealth JID - 101624439 SB - IM MH - Humans MH - Pilot Projects MH - Female MH - *Poverty/statistics & numerical data/psychology MH - Adult MH - Male MH - *Exercise/psychology MH - Adolescent MH - Middle Aged MH - Digital Health MH - Text Messaging/instrumentation/statistics & numerical data MH - Telemedicine/instrumentation MH - Wearable Electronic Devices/statistics & numerical data/standards PMC - PMC13282599 OTO - NOTNLM OT - African American OT - community engagement OT - medically underserved OT - text messaging OT - wearables COIS- Conflicts of Interest: None declared. EDAT- 2026/06/05 18:36 MHDA- 2026/06/11 06:39 PMCR- 2026/06/05 CRDT- 2026/06/05 16:53 PHST- 2025/05/20 00:00 [received] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/05/07 00:00 [revised] PHST- 2026/06/11 06:39 [medline] PHST- 2026/06/05 18:36 [pubmed] PHST- 2026/06/05 16:53 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - v14i1e76991 [pii] AID - 10.2196/76991 [doi] PST - epublish SO - JMIR Mhealth Uhealth. 2026 Jun 5;14:e76991. doi: 10.2196/76991. PMID- 42247675 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260908 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Jun 5 TI - Evaluating the Effectiveness of the School-Based Sustainable Innovation for Children Transporting Actively Intervention: Protocol for an Age-Cohort Study. PG - e92946 LID - 10.2196/92946 [doi] LID - e92946 AB - BACKGROUND: Few children achieve the recommended daily levels of physical activity. Active school transportation (AST) offers a valuable opportunity to increase children's physical activity. Initiatives promoting AST in early childhood are important and have the potential to reverse the decline in physical activity. OBJECTIVE: This study protocol outlines an age-cohort design to evaluate the effectiveness of the Sustainable Innovation for Children Transporting Actively (SICTA) intervention on children's AST. METHODS: SICTA is a 4-week school-based intervention that incorporates gamification elements to enhance motivation and aims to increase AST in children. The intervention involves children and their parents as gatekeepers, as well as teachers delivering the intervention. All children, parents, and teachers in all schools, from grades 4 to 6 in one municipality in the southern part of Sweden, will be invited to participate in the evaluation. Following the age-cohort design, students at baseline (late fall 2024) will be compared with students of the same age from the same schools 1 year later at follow-up (late fall 2025) after receiving the intervention (implemented in late fall 2025). Using questionnaires at baseline and follow-up, this study will examine the effects of the intervention on children's levels of AST. Children's independent mobility and several mediators related to AST in both children and parents, based on the theory of planned behavior, the transtheoretical model of change, and self-determination theory, will also be examined. The intervention will also be evaluated from a sustainable perspective using the sustainable value equation. At follow-up, data collection will include a questionnaire for teachers assessing the feasibility of the intervention. RESULTS: The project is funded for the period 2024-2026, and follow-up data collection is ongoing following completion of the intervention in late fall 2025. Results will be reported according to the predefined outcomes, including changes in AST, children's independent mobility, psychosocial determinants among children and parents, and sustainability outcomes, as well as feasibility. CONCLUSIONS: The findings are expected to provide valuable insights into the effectiveness of the SICTA intervention, facilitating knowledge dissemination among end users and policymakers. TRIAL REGISTRATION: Swedish National Research Database Researchweb.org 283668; https://tinyurl.com/496rc6r4. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/92946. CI - (c)Hanna Forsberg, Anna-Karin Lindqvist, Stina Rutberg, Palma Chillon, Veronica Sjoberg, Annie Palstam. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 05.06.2026. FAU - Forsberg, Hanna AU - Forsberg H AUID- ORCID: 0000-0002-1239-9675 AD - Department of Health, Education and Technology, Lulea University of Technology, Lulea, Norrbotten, Sweden. FAU - Lindqvist, Anna-Karin AU - Lindqvist AK AUID- ORCID: 0000-0003-3145-7698 AD - Department of Health, Education and Technology, Lulea University of Technology, Lulea, Norrbotten, Sweden. FAU - Rutberg, Stina AU - Rutberg S AUID- ORCID: 0000-0001-9376-6053 AD - Department of Health, Education and Technology, Lulea University of Technology, Lulea, Norrbotten, Sweden. FAU - Chillon, Palma AU - Chillon P AUID- ORCID: 0000-0003-0862-8989 AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), Universidad de Granada, Granada, Andalusia, Spain. FAU - Sjoberg, Veronica AU - Sjoberg V AUID- ORCID: 0000-0002-3843-0407 AD - School of Health and Welfare, Dalarna University, Falun, Dalarna, Sweden. FAU - Palstam, Annie AU - Palstam A AUID- ORCID: 0000-0002-7127-213X AD - School of Health and Welfare, Dalarna University, Falun, Dalarna, Sweden. AD - Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Shalgrenska Academy, University of Gothenburg, Gothenburg, Vastra Gotaland, Sweden. AD - Rehabilitation Medicine, Sahlgrenska University Hospital, Gothenburg, Vastra Gotaland, Sweden. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260605 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Sweden MH - *Transportation/methods/standards MH - Child MH - Cohort Studies MH - Schools MH - *Exercise/psychology MH - Surveys and Questionnaires MH - Female MH - Male MH - Program Evaluation/methods MH - Research Design MH - Students/statistics & numerical data/psychology MH - *Health Promotion/methods PMC - PMC13282597 OTO - NOTNLM OT - active commuting OT - age cohort OT - feasibility OT - physical activity OT - sustainability COIS- Conflicts of Interest: None declared. EDAT- 2026/06/05 18:36 MHDA- 2026/06/11 18:35 PMCR- 2026/06/05 CRDT- 2026/06/05 16:52 PHST- 2026/02/14 00:00 [received] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/04/25 00:00 [revised] PHST- 2026/06/11 18:35 [medline] PHST- 2026/06/05 18:36 [pubmed] PHST- 2026/06/05 16:52 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - v15i1e92946 [pii] AID - 10.2196/92946 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Jun 5;15:e92946. doi: 10.2196/92946. PMID- 42247658 OWN - NLM STAT- MEDLINE DCOM- 20260610 LR - 20260908 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Jun 5 TI - Screen-Free Time With Friends to Promote Face-to-Face Peer Interaction and Reduce Recreational Screen Use Among Children Aged 9-11 Years: Protocol for a Cluster Randomized Controlled Trial. PG - e84831 LID - 10.2196/84831 [doi] LID - e84831 AB - BACKGROUND: Children's leisure time has changed in recent decades-with more time spent on screen media and less time face-to-face with peers-potentially affecting their physical and mental well-being. OBJECTIVE: This protocol outlines a cluster randomized controlled trial evaluating the Screen-Free Time With Friends intervention, which aims to promote face-to-face peer interaction and reduce recreational screen media use among children aged 9-11 years. METHODS: The study is conducted as a cluster randomized controlled trial involving 9-11-year-old children and their parents from 18 schools in Denmark. Schools are randomized (1:1) to either a control or an intervention group. The intervention includes five core components: (1) curricular activities, (2) two family meetings, (3) a brief parent exercise, (4) a development program for after-school clubs, and (5) two community workshops. It is designed to allow local adaptation while maintaining fidelity to the core components. Primary and key secondary outcomes, including face-to-face peer interaction across leisure domains and solitary screen time, are assessed at baseline, 6-10 months, and 13-15 months follow-up. Additional exploratory outcomes (e.g., leisure activities, social relations, and well-being) are measured at baseline and follow-up. Time spent in face-to-face interactions with peers was assessed using a short SMS-based questionnaire sent to registered parents. The instrument has not been formally validated but was tested in a feasibility study. A comprehensive process evaluation explores implementation, context, and mechanisms of change. RESULTS: The project was funded in July 2020. Schools were recruited from July 2023 to January 2024, while children and parents were recruited from November 2023 to April 2024. At baseline, 685 children were enrolled at the participating schools, with 343 (50%) having at least one parent enrolled in the questionnaire. The primary outcome is therefore assessed among a subset of participants, which may affect the effective sample size. Baseline data were collected from December 2023 to June 2024, and follow-up data from March to August 2025. As of March 2026, data analysis has not yet commenced, and no study results are currently available. Findings are expected to be published by the end of 2026. CONCLUSIONS: Regardless of the findings, this study will generate important knowledge about the intervention's potential effectiveness, complemented by insights into its implementation, context, and mechanisms of change. These insights can assist municipalities, schools, after-school clubs, community stakeholders, and parents in shaping everyday environments that foster children's face-to-face interaction and encourage balanced screen use. The findings may inform policy decisions, guide the development of new national and local initiatives, and inspire future research into feasible, real-world interventions that support meaningful and enriching leisure experiences for children. CI - (c) Sara Kruse Lange, Sarah Overgaard Slater, Teresa Victoria Hoy, Kristian Traberg Larsen, Anders Blaedel Gottlieb Hansen, Russell Jago, Peter Lund Kristensen, Anders Grontved, Mette Toftager, Anne Kaer Gejl. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Lange, Sara Kruse AU - Lange SK AUID- ORCID: 0009-0003-6477-2325 AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. FAU - Sorensen, Sarah Overgaard AU - Sorensen SO AUID- ORCID: 0000-0002-3953-3387 AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. FAU - Hoy, Teresa Victoria AU - Hoy TV AUID- ORCID: 0000-0002-2452-1535 AD - National Institute of Public Health, Faculty of Health Sciences, University of Southern Denmark, Copenhagen, Denmark. FAU - Larsen, Kristian Traberg AU - Larsen KT AUID- ORCID: 0000-0002-3918-6645 AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. FAU - Hansen, Anders Blaedel Gottlieb AU - Hansen ABG AUID- ORCID: 0000-0001-6777-2257 AD - Center for Clinical Research and Prevention, Copenhagen University Hospital, Frederiksberg, Denmark. FAU - Jago, Russell AU - Jago R AUID- ORCID: 0000-0002-3394-0176 AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom. FAU - Kristensen, Peter Lund AU - Kristensen PL AUID- ORCID: 0000-0002-5666-9614 AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. FAU - Grontved, Anders AU - Grontved A AUID- ORCID: 0000-0003-1584-679X AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. FAU - Toftager, Mette AU - Toftager M AUID- ORCID: 0000-0002-6736-3725 AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. FAU - Gejl, Anne Kaer AU - Gejl AK AUID- ORCID: 0000-0001-6781-2263 AD - Department of Sports Science and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Campusvej 55, Odense, 5230, Denmark, 45 65507908. LA - eng SI - ClinicalTrials.gov/NCT06163495 PT - Clinical Trial Protocol PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260605 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Child MH - Female MH - Humans MH - Male MH - Denmark MH - *Friends/psychology MH - Interpersonal Relations MH - Leisure Activities MH - *Peer Group MH - *Screen Time MH - Surveys and Questionnaires MH - Randomized Controlled Trials as Topic PMC - PMC13240986 OTO - NOTNLM OT - after-school programs OT - child OT - community participation OT - digital media use OT - interpersonal relations OT - mental health OT - physical activity OT - screen time OT - social interaction OT - well-being COIS- Conflicts of Interest: None declared. EDAT- 2026/06/05 18:36 MHDA- 2026/06/11 05:42 PMCR- 2026/06/05 CRDT- 2026/06/05 16:12 PHST- 2025/09/26 00:00 [received] PHST- 2026/03/30 00:00 [revised] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/06/11 05:42 [medline] PHST- 2026/06/05 18:36 [pubmed] PHST- 2026/06/05 16:12 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - v15i1e84831 [pii] AID - 84831 [pii] AID - 10.2196/84831 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Jun 5;15:e84831. doi: 10.2196/84831. PMID- 42247646 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260813 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 28 DP - 2026 Jun 5 TI - Digital and Blended Lifestyle Interventions for Preschool-Aged Children and Families With a Low Socioeconomic Position and the General Population: Scoping Review. PG - e86596 LID - 10.2196/86596 [doi] LID - e86596 AB - BACKGROUND: Many unhealthy habits develop in early childhood and can lead to long-term health risks, which disproportionately affect children with low socioeconomic position (SEP). Digital and blended lifestyle interventions can promote healthier lifestyles, yet families with lower SEP remain underrepresented and face unique barriers to healthy behaviors and intervention access. As a result, it remains unclear which intervention characteristics are most effective for these populations. OBJECTIVE: This study aimed to identify and map digital and blended lifestyle interventions targeting preschool-aged children and explore how intervention characteristics and reported effectiveness patterns differ between interventions for the general population and low SEP families. METHODS: A search across Scopus, Web of Science, Cochrane Library, ERIC, and ACM Digital Library was conducted. Studies were eligible if they (1) targeted preschool-aged children (6 months to 5 years) or caregivers, (2) evaluated a digital or blended lifestyle intervention, and (3) addressed at least one behavioral domain (nutrition, physical activity, sedentary behavior, sleep, and oral health). Studies focusing on pregnant women, children aged >5 years, or interventions delivered solely nondigitally were excluded. Screening and prioritization were supported by artificial intelligence-assisted software (ASReview; Utrecht University). Data covered intervention targets, populations, theoretical and guideline foundations, delivery modes and settings, and persuasive systems design features. Intervention characteristics and effectiveness categories were synthesized descriptively. The methodological quality of quasi-experimental studies was assessed using the Joanna Briggs Institute critical appraisal tools. RESULTS: A total of 77 studies describing 54 interventions were included. Of these, 35 targeted the general population, and 19 focused solely on low SEP families. Interventions were similar across groups: typically parent-focused, targeting multiple lifestyle domains, and informed by theories, frameworks, or evidence-based guidelines. Low SEP interventions more often used text messaging, included fewer persuasive design features, and tended toward single delivery channels. Effectiveness findings were mixed; no consistent patterns emerged when interventions were grouped by their characteristics. Among low SEP interventions only, less effective interventions more often targeted multiple behaviors and included more persuasive systems design features. CONCLUSIONS: To our knowledge, this is one of the first reviews to map digital and blended lifestyle interventions for preschool-aged children while comparing intervention characteristics and descriptive effectiveness patterns across general and low SEP populations. The review highlights heterogeneity in intervention characteristics and outcomes and identifies gaps where evidence is limited. These findings underscore the need to better represent low SEP families in intervention research, strengthen understanding of feasibility and contextual fit, and support multilevel approaches that reflect families' everyday contexts. However, the findings should be interpreted in light of several limitations, including the exclusion of gray literature, partial double-screening, the possibility that artificial intelligence-assisted prioritization may have omitted relevant studies, and variation in the reporting of intervention components across studies. CI - (c) Lea Hohendorf, Tessa Dekkers, Hanneke Kip, Laurence Alpay, Saskia M Kelders. Originally published in the Journal of Medical Internet Research (https://www.jmir.org). FAU - Hohendorf, Lea AU - Hohendorf L AUID- ORCID: 0009-0000-3738-6320 AD - Health Psychology & Technology, Faculty of Behavioural, Management and Social Sciences, University of Twente, Drienerlolaan 5, Enschede, Overijssel, 7522 NB, The Netherlands, 49 1708162426. AD - Medical Technology Research Group, Faculty of Healthcare, Sport & Well-being, Inholland University of Applied Sciences, Haarlem, The Netherlands. FAU - Dekkers, Tessa AU - Dekkers T AUID- ORCID: 0000-0003-2787-3293 AD - Health Psychology & Technology, Faculty of Behavioural, Management and Social Sciences, University of Twente, Drienerlolaan 5, Enschede, Overijssel, 7522 NB, The Netherlands, 49 1708162426. FAU - Kip, Hanneke AU - Kip H AUID- ORCID: 0000-0002-6661-2128 AD - Health Psychology & Technology, Faculty of Behavioural, Management and Social Sciences, University of Twente, Drienerlolaan 5, Enschede, Overijssel, 7522 NB, The Netherlands, 49 1708162426. AD - Department of Research, Stichting Transfore, Deventer, The Netherlands. FAU - Alpay, Laurence AU - Alpay L AUID- ORCID: 0000-0002-8243-0607 AD - Medical Technology Research Group, Faculty of Healthcare, Sport & Well-being, Inholland University of Applied Sciences, Haarlem, The Netherlands. FAU - Kelders, Saskia M AU - Kelders SM AUID- ORCID: 0000-0001-8949-6871 AD - Health Psychology & Technology, Faculty of Behavioural, Management and Social Sciences, University of Twente, Drienerlolaan 5, Enschede, Overijssel, 7522 NB, The Netherlands, 49 1708162426. AD - Optentia Research Focus Area, Vaal Triangle Campus, North-West University, Vanderbijlpark, South Africa. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260605 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 SB - IM MH - Humans MH - Child, Preschool MH - *Life Style MH - Low Socioeconomic Status MH - *Health Promotion/methods MH - Digital Media MH - Digital Health MH - Infant PMC - PMC13240985 OTO - NOTNLM OT - digital health interventions OT - eHealth OT - effectiveness OT - health behaviors OT - intervention characteristics OT - intervention evaluation OT - lifestyle interventions OT - low socioeconomic position OT - persuasive systems design OT - preschool-aged children COIS- Conflicts of Interest: None declared. EDAT- 2026/06/05 18:36 MHDA- 2026/06/11 06:36 PMCR- 2026/06/05 CRDT- 2026/06/05 16:03 PHST- 2025/10/27 00:00 [received] PHST- 2026/04/10 00:00 [revised] PHST- 2026/04/11 00:00 [accepted] PHST- 2026/06/11 06:36 [medline] PHST- 2026/06/05 18:36 [pubmed] PHST- 2026/06/05 16:03 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - v28i1e86596 [pii] AID - 86596 [pii] AID - 10.2196/86596 [doi] PST - epublish SO - J Med Internet Res. 2026 Jun 5;28:e86596. doi: 10.2196/86596. PMID- 42247287 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260711 IS - 1744-8409 (Electronic) IS - 1744-666X (Linking) VI - 22 IP - 6 DP - 2026 Jun TI - Measuring disease activity in juvenile systemic sclerosis: a multidisciplinary consensus from the Hamburg 2024 symposium. PG - 645-660 LID - 10.1080/1744666X.2026.2685050 [doi] AB - INTRODUCTION: Assessment of disease activity in juvenile systemic sclerosis (jSSc) is essential for clinical care and trial readiness, yet no validated pediatric activity measures exist. Adult systemic sclerosis activity tools, including the Scleroderma Clinical Trials Consortium Activity Index, revised CRISS, and revised EUSTAR, provide conceptual frameworks but require adaptation for developmental, physiologic, and feasibility considerations for children. At the 17th Hamburg Symposium on JSSc, an international multidisciplinary panel reviewed adult indices, evaluated corresponding variables in the jSSc Inception Cohort and the NRCOS registry, and conducted a structured Delphi process to define organ-specific indicators of clinically meaningful activity in jSSc. AREAS COVERED: Across skin, pulmonary, cardiac, vascular, musculoskeletal, gastrointestinal, renal, and global domains, the panel reached broad and often unanimous consensus on variables reflecting active, potentially reversible disease. Key endorsed measures included mRSS progression, new ILD on HRCT, >/=10% declines in FVC or DLCO, new cardiac abnormalities, active digital ulcers, synovitis, myositis, nutritional decline, and physician global assessment. Patient-reported outcomes were strongly supported across domains. EXPERT OPINION: These consensus-derived indicators provide the first comprehensive pediatric-specific foundation for defining disease activity in jSSc and represent a critical step toward developing and validating a unified pediatric activity index suitable for future clinical trials. FAU - Foeldvari, Ivan AU - Foeldvari I AUID- ORCID: 0000-0003-0659-5298 AD - Hamburg Centre for Pediatric and Adolescent Rheumatology, Schon Klinik Hamburg Eilbek, Hamburg, Germany. FAU - Torok, Kathryn S AU - Torok KS AD - Division of Pediatric Rheumatology, UPMC & University of Pittsburgh Scleroderma Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Klotsche, Jens AU - Klotsche J AD - German Rheumatism Research Center, Berlin, Germany. FAU - Li, Jonathan C AU - Li JC AD - Division of Pediatric Rheumatology, UPMC & University of Pittsburgh Scleroderma Center, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Bruni, Cosimo AU - Bruni C AD - Department of Rheumatology, University Hospital Zurich, University of Zurich, Zurich, Switzerland. FAU - Costa-Reis, Patricia AU - Costa-Reis P AD - Pediatrics Department, Hospital de Santa Maria, Faculdade de Medicina, Universidade de Lisboa, Lisbon, Portugal. FAU - Cutolo, Maurizio AU - Cutolo M AD - Laboratory of Experimental Rheumatology and Academic Division of Clinical Rheumatology-Department of Internal Medicine and Specialties, University of Genoa and IRCCS San Martino Polyclinic Hospital, Genoa, Italy. FAU - Denton, Christopher P AU - Denton CP AD - UCL Division of Medicine, Royal Free London NHS Foundation Trust, London, UK. FAU - Fligelstone, Kim AU - Fligelstone K AD - Scleroderma & Raynaud's United Kindgom (SRUK) (Research Subcommittee, Patient Research Partner), FESCA, London, UK. FAU - Del Galdo, Francesco AU - Del Galdo F AD - Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, and NIHR Biomedical Research Centre, Leeds Teaching Hospital Trust, Leeds, UK. FAU - Gimenez-Roca, Clara AU - Gimenez-Roca C AD - Department of Pediatric Rheumatology, Hospital Sant Joan de Deu, Esplugues de Llobregat (Barcelona), Spain. FAU - Henes, Jorg AU - Henes J AD - Centre for Interdisciplinary Clinical Immunology, Rheumatology and Autoinflammatory Diseases and Department for Internal Medicine II, University Hospital Tubingen, Tubingen, Germany. FAU - Kasapcopur, Ozgur AU - Kasapcopur O AD - Department of Pediatric Rheumatology, Cerrahpasa Medical School, Istanbul University - Cerrahpasa, Istanbul, Turkey. FAU - Li, Suzanne C AU - Li SC AD - Joseph M Sanzari Children's Hospital, Hackensack Meridian School of Medicine, Hackensack, NJ, USA. FAU - Marrani, Edoardo AU - Marrani E AD - Pediatric Rheumatology, Meyer Children's Hospital IRCCS, Firenze, Italy. FAU - Orteu, Catherine H AU - Orteu CH AD - UCL Institute of Immunity and Transplantation, Royal Free London NHS Foundation Trust, London, UK. FAU - Pauling, John D AU - Pauling JD AD - North Bristol NHS Trust, Bristol, UK. FAU - Pilkington, Clarissa AU - Pilkington C AD - Pediatric Rheumatology, Great Ormond Street Hospital, London, UK. FAU - Ross, Laura AU - Ross L AD - Department of Medicine, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia. AD - Department of Rheumatology, St Vincent's Hospital Melbourne, Fitzroy, Australia. FAU - Schonenberg-Meinema, Dieneke AU - Schonenberg-Meinema D AD - Department of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands. FAU - Furst, Daniel E AU - Furst DE AD - Rheumatology, University of California, Los Angeles, CA, USA. AD - University of Washington, Seattle, WA, USA. AD - Pediatric Rheumatology, University of Florence, Florence, Italy. FAU - Smith, Vanessa AU - Smith V AD - Department of Internal Medicine, Ghent University, Ghent, Belgium. AD - Department of Rheumatology, Ghent University Hospital, Ghent, Belgium. AD - Unit for Molecular Immunology and Inflammation, VIB Inflammation Research Center (IRC), Ghent, Belgium. AD - Rheumatology, ERN ReCONNET, Ghent, Belgien. LA - eng GR - Scleroderma Clinical Trial Consortium/ GR - National Scleroderma Foundation/ PT - Consensus Statement PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20260622 PL - England TA - Expert Rev Clin Immunol JT - Expert review of clinical immunology JID - 101271248 RN - Juvenile systemic scleroderma SB - IM MH - Child MH - Humans MH - Disease Progression MH - *Scleroderma, Systemic/diagnosis MH - Severity of Illness Index OTO - NOTNLM OT - Clinical trials OT - consensus OT - disease activity OT - disease activity index OT - juvenile systemic sclerosis OT - outcome measures OT - pediatric rheumatology EDAT- 2026/06/05 18:36 MHDA- 2026/06/30 06:30 CRDT- 2026/06/05 12:33 PHST- 2026/06/30 06:30 [medline] PHST- 2026/06/05 18:36 [pubmed] PHST- 2026/06/05 12:33 [entrez] AID - 10.1080/1744666X.2026.2685050 [doi] PST - ppublish SO - Expert Rev Clin Immunol. 2026 Jun;22(6):645-660. doi: 10.1080/1744666X.2026.2685050. Epub 2026 Jun 22. PMID- 42246427 OWN - NLM STAT- MEDLINE DCOM- 20260917 LR - 20260917 IS - 1525-6073 (Electronic) IS - 0742-0528 (Linking) VI - 43 IP - 10 DP - 2026 Oct TI - L5 onset as a proxy for circadian phase in infants. PG - 1518-1523 LID - 10.1080/07420528.2026.2681616 [doi] AB - Chronotype is commonly assessed using the mid-sleep point as an indicator of circadian phase. In infants, however, this assessment typically relies on actigraphy, and most available sleep-scoring algorithms have been developed and validated for adolescents and adults, limiting their applicability in early childhood. The aim of this study was to examine the relationship between the mid-sleep point and L5 onset, a nonparametric measure derived from rest-activity rhythms that reflects the start of the least active 5-h period. A total of 502 nights from 81 six-month-old infants were analyzed. Sleep onset and offset were determined by visual inspection of actograms, and the mid-sleep point was subsequently calculated. A positive correlation was observed between mid-sleep point and L5 onset (r = 0.22, p < 0.001). Linear mixed-effects models indicated significant associations both between infants (beta = 0.63, p < 0.001) and within infants (beta = 0.10, p < 0.001). These findings suggest that L5 onset may serve as a practical proxy for circadian phase in 6-month-old infants, offering an alternative to sleep parameters derived from algorithms not specifically validated for this age group. FAU - Buest de Mesquita Silva, Rebeca AU - Buest de Mesquita Silva R AUID- ORCID: 0000-0002-8288-7391 AD - Physiology Department, Federal University of Parana, Curitiba, Brazil. FAU - Holler Pykocz, Adrielle AU - Holler Pykocz A AUID- ORCID: 0009-0008-7761-6176 AD - Physiology Department, Federal University of Parana, Curitiba, Brazil. FAU - Victoria Leal, Hanna AU - Victoria Leal H AD - Physiology Department, Federal University of Parana, Curitiba, Brazil. FAU - Leocadio-Miguel, Mario Andre AU - Leocadio-Miguel MA AUID- ORCID: 0000-0002-7248-3529 AD - School of Psychology, Northumbria University, Newcastle Upon Tyne, UK. FAU - Louzada, Fernando Mazzilli AU - Louzada FM AUID- ORCID: 0000-0002-4982-8082 AD - Physiology Department, Federal University of Parana, Curitiba, Brazil. FAU - Group, Cpapi AU - Group C AD - Brazilian Center for Early Childhood Development, Insper, Sao Paulo, Brazil. LA - eng PT - Journal Article DEP - 20260605 PL - England TA - Chronobiol Int JT - Chronobiology international JID - 8501362 SB - IM MH - Humans MH - Infant MH - *Circadian Rhythm/physiology MH - *Sleep/physiology MH - Female MH - Male MH - Actigraphy MH - Chronotype MH - Algorithms OTO - NOTNLM OT - L5 onset OT - circadian phase OT - infant sleep OT - mid-sleep point EDAT- 2026/06/05 12:41 MHDA- 2026/09/17 15:36 CRDT- 2026/06/05 07:34 PHST- 2026/09/17 15:36 [medline] PHST- 2026/06/05 12:41 [pubmed] PHST- 2026/06/05 07:34 [entrez] AID - 10.1080/07420528.2026.2681616 [doi] PST - ppublish SO - Chronobiol Int. 2026 Oct;43(10):1518-1523. doi: 10.1080/07420528.2026.2681616. Epub 2026 Jun 5. PMID- 42245835 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260605 LR - 20260813 IS - 1664-042X (Print) IS - 1664-042X (Electronic) IS - 1664-042X (Linking) VI - 17 DP - 2026 TI - Sex-specific BMI, 24-hour movement behaviors, motor skills, and executive functions in Tunisian preschool children: an observational cross-sectional study. PG - 1853244 LID - 10.3389/fphys.2026.1853244 [doi] LID - 1853244 AB - BACKGROUND: Early childhood is a critical period for motor, cognitive, and behavioral development, and the rising prevalence of overweight and obesity are associated with differences in physical activity (PA), motor skills (MS), and executive functions (EF). This study aimed to examine associations between sex-specific BMI categories, 24-hour movement behaviors (MB), MS, and EF in Tunisian preschool children. METHODS: A cross-sectional observational study included 112 children aged 4-5 years (50 boys, 62 girls) from urban and rural kindergartens. Anthropometric measures classified children into sex-specific BMI categories (below normal, normal, above normal). PA, sedentary behavior (SB), and sleep were objectively assessed via accelerometry over five consecutive days. EF (inhibition, working memory) and MS (functional mobility, balance, upper and lower limb strength, manual dexterity) were evaluated using standardized and validated tests. RESULTS: Overall, BMI showed limited associations with MB, EF, and MS, but some sex-specific associations were observed. Statistically significant differences were found for upper-body strength (girls, p = 0.003), moderate intensity PA (girls, p = 0.040), and screen-based SB (boys, p = 0.049). No statistically significant differences were observed for functional mobility, balance, lower limb strength, manual dexterity, other PA measures, sleep, or EF. Anthropometric scores were higher in BMI > normal groups, most children met MVPA and sleep recommendations, but total PA compliance was low. CONCLUSION: This study provides novel evidence from a North African context on sex-specific associations between BMI, MB, MS, and EF in preschool children. Findings indicate limited but domain-specific functional implications of BMI and emphasize the need for longitudinal, sex-stratified studies with larger samples to clarify developmental trajectories. However, due to the cross-sectional design, these findings reflect associations only, and no causal inferences can be drawn from these results. CI - Copyright (c) 2026 Meksi, Ltifi, Alfawaz, Alotaibi and Chelly. FAU - Meksi, Sonia AU - Meksi S AD - Research Laboratory (LR23JS01), Sport Performance, Health & Society, Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Tunis, Tunisia. FAU - Ltifi, Mohamed Amine AU - Ltifi MA AD - Research Laboratory (LR23JS01), Sport Performance, Health & Society, Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Tunis, Tunisia. AD - University of Gafsa, Higher Institute of Sport and Physical Education of Gafsa, Gafsa, Tunisia. FAU - Alfawaz, Waad AU - Alfawaz W AD - Community Health Sciences Department, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia. FAU - Alotaibi, Abdulazeem AU - Alotaibi A AD - Department of Physical Education and Kinesiology, College of Education, Qassim University, Qassim, Saudi Arabia. FAU - Chelly, Mohamed Souhaiel AU - Chelly MS AD - Research Laboratory (LR23JS01), Sport Performance, Health & Society, Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Tunis, Tunisia. LA - eng PT - Journal Article DEP - 20260520 PL - Switzerland TA - Front Physiol JT - Frontiers in physiology JID - 101549006 PMC - PMC13229776 OTO - NOTNLM OT - 24-hour movement behaviors OT - BMI OT - North Africa OT - executive functions OT - motor skills OT - observational study OT - preschool children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor SH declared a past co-authorship with the author ML. The author MSC declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/06/05 06:36 MHDA- 2026/06/05 06:37 PMCR- 2026/05/20 CRDT- 2026/06/05 05:08 PHST- 2026/04/11 00:00 [received] PHST- 2026/05/01 00:00 [revised] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/06/05 06:37 [medline] PHST- 2026/06/05 06:36 [pubmed] PHST- 2026/06/05 05:08 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - 10.3389/fphys.2026.1853244 [doi] PST - epublish SO - Front Physiol. 2026 May 20;17:1853244. doi: 10.3389/fphys.2026.1853244. eCollection 2026. PMID- 42245271 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260605 LR - 20260813 IS - 1178-7007 (Print) IS - 1178-7007 (Electronic) IS - 1178-7007 (Linking) VI - 19 DP - 2026 TI - Plasma Melanin-Concentrating Hormone in Childhood Obesity and Its Association with Metabolic Parameters: A Clinical Observational Study. PG - 590517 LID - 10.2147/DMSO.S590517 [doi] LID - 590517 AB - INTRODUCTION: Obesity is a global public health problem associated with complex neuroendocrine dysregulation. Melanin-concentrating hormone (MCH), a hypothalamic regulator of energy balance, promotes appetite and positive energy balance and has been linked to metabolic disturbances in adults. However, its clinical relevance in childhood obesity, where neuroendocrine alterations may precede overt metabolic complications, remains insufficiently characterized. AIM: This study aimed to determine whether plasma MCH levels are associated with metabolic alterations in children and adolescents with obesity. METHODS: In this clinical observational study, 283 participants were classified according to World Health Organization BMI-for-age criteria into obese and normal-weight groups. Plasma MCH concentrations were measured using a validated high-sensitivity radioimmunoassay (analytical detection limit: 0.2 fmol/mL). Anthropometric parameters, glucose-insulin homeostasis markers (glucose, insulin, C-peptide, HOMA-IR), lipid profile, thyroid hormones, and liver enzymes were assessed. Associations were analyzed using Spearman correlation after non-parametric distribution testing. RESULTS: Plasma MCH exhibited limited and selective associations with metabolic parameters in obese children and adolescents. Modest correlations were observed within the glucose-insulin and thyroid-related domains, whereas associations with lipid profile measures were weak or inverse. These patterns suggest age-dependent neuroendocrine involvement in pediatric obesity. CONCLUSION: Elevated plasma MCH levels in childhood obesity are associated with selective neuroendocrine and metabolic alterations rather than overt dyslipidemia. In view of the cross-sectional design and modest effect sizes, these findings should be considered exploratory and require confirmation in longitudinal pediatric studies. CI - (c) 2026 Leiter et al. FAU - Leiter, Imre AU - Leiter I AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Lelesz, Beata AU - Lelesz B AUID- ORCID: 0009-0001-4922-7359 AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Hegedus, Csaba AU - Hegedus C AUID- ORCID: 0000-0001-8067-2701 AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Nemeth, Jozsef AU - Nemeth J AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Pelles-Tasko, Beata AU - Pelles-Tasko B AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Ujlaki, Gyula AU - Ujlaki G AUID- ORCID: 0000-0001-8376-3940 AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Bhattoa, Harjit Pal AU - Bhattoa HP AD - Institute of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Felszeghy, Eniko Noemi AU - Felszeghy EN AD - Institute of Pediatrics, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Lengyel, Szabolcs AU - Lengyel S AD - Department of Clinical Pharmacology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Pall, Denes AU - Pall D AD - Department of Clinical Pharmacology, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Balla, Gyorgy AU - Balla G AD - Institute of Pediatrics, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Szilvassy, Zoltan AU - Szilvassy Z AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Juhasz, Bela AU - Juhasz B AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. FAU - Kiss, Rita AU - Kiss R AUID- ORCID: 0000-0003-1208-366X AD - Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Debrecen, Debrecen, Hungary. LA - eng PT - Journal Article DEP - 20260529 PL - New Zealand TA - Diabetes Metab Syndr Obes JT - Diabetes, metabolic syndrome and obesity : targets and therapy JID - 101515585 PMC - PMC13231885 OTO - NOTNLM OT - MCH OT - appetite regulation OT - energy homeostasis OT - insulin OT - juvenile obesity OT - neuropeptide signaling OT - radioimmunoassay COIS- The author(s) report no conflicts of interest in this work. EDAT- 2026/06/05 06:35 MHDA- 2026/06/05 06:36 PMCR- 2026/05/29 CRDT- 2026/06/05 05:02 PHST- 2026/01/01 00:00 [received] PHST- 2026/03/03 00:00 [accepted] PHST- 2026/06/05 06:36 [medline] PHST- 2026/06/05 06:35 [pubmed] PHST- 2026/06/05 05:02 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - 590517 [pii] AID - 10.2147/DMSO.S590517 [doi] PST - epublish SO - Diabetes Metab Syndr Obes. 2026 May 29;19:590517. doi: 10.2147/DMSO.S590517. eCollection 2026. PMID- 42245268 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260605 LR - 20260813 IS - 1178-7007 (Print) IS - 1178-7007 (Electronic) IS - 1178-7007 (Linking) VI - 19 DP - 2026 TI - Body Appreciation and Weight Control Behaviors in Overweight Adolescents: A Cross-Sectional Study Informing a CBT-Based Health Promotion Model. PG - 594983 LID - 10.2147/DMSO.S594983 [doi] LID - 594983 AB - BACKGROUND: Overweight and obesity in adolescents have become significant public health issues, with traditional interventions showing limited effectiveness. Cognitive behavioral therapy (CBT) offers a novel approach to adolescent health promotion by altering individuals' cognitive and behavioral patterns. OBJECTIVE: This study was designed to construct a health behavior promotion model for overweight adolescents integrating CBT theory and to empirically validate it based on multidimensional behavioral scoring. METHODS: A cross-sectional study was conducted among 294 adolescents aged 13-16 from three secondary schools. Participants were classified into overweight/obese (n = 86) and normal weight (n = 208) groups based on BMI criteria. Data were collected using the Body Appreciation Scale-2, Weight Control Practices Questionnaire, and Comprehensive Lifestyle Assessment Scale. Statistical analyses included independent t-tests, Pearson correlation, structural equation modeling (SEM), and multiple regression. RESULTS: Overweight adolescents scored significantly lower in body appreciation cognition (t = 4.32, p < 0.001) and healthy weight control behaviors (t = 3.87, p < 0.001), and higher in unhealthy weight control behaviors (t = 4.96, p < 0.001). SEM revealed that body appreciation cognition had a direct negative effect on BMI (beta = -0.18, p < 0.01) and an indirect effect through healthy weight control behaviors (beta = -0.12, p < 0.05). The model demonstrated good fit (chi(2)/df = 2.36, CFI = 0.94, RMSEA = 0.06). CONCLUSION: The findings support the applicability of a CBT-based health behavior promotion model for overweight adolescents. The model, encompassing cognitive restructuring, behavioral activation, self-monitoring, and relapse prevention, provides a theoretical foundation for school- and community-based interventions. CI - (c) 2026 Wu et al. FAU - Wu, Xiaoqiu AU - Wu X AD - Department of Nursing, The Second Hospital of Jinhua, Jinhua, 321016, People's Republic of China. FAU - Xu, Qunying AU - Xu Q AD - Department of Supervision Ward, The Second Hospital of Jinhua, Jinhua, 321016, People's Republic of China. FAU - Wu, Zhen AU - Wu Z AD - Department of Nursing, The Second Hospital of Jinhua, Jinhua, 321016, People's Republic of China. FAU - Zheng, Lanzhen AU - Zheng L AD - Department of Nursing, The Second Hospital of Jinhua, Jinhua, 321016, People's Republic of China. LA - eng PT - Journal Article DEP - 20260529 PL - New Zealand TA - Diabetes Metab Syndr Obes JT - Diabetes, metabolic syndrome and obesity : targets and therapy JID - 101515585 PMC - PMC13231876 OTO - NOTNLM OT - adolescents OT - behavioral intervention OT - cognitive behavioral therapy OT - health behaviors OT - overweight COIS- All of the authors had no any personal, financial, commercial, or academic conflicts of interest separately. EDAT- 2026/06/05 06:36 MHDA- 2026/06/05 06:37 PMCR- 2026/05/29 CRDT- 2026/06/05 05:02 PHST- 2026/01/15 00:00 [received] PHST- 2026/03/26 00:00 [accepted] PHST- 2026/06/05 06:37 [medline] PHST- 2026/06/05 06:36 [pubmed] PHST- 2026/06/05 05:02 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - 594983 [pii] AID - 10.2147/DMSO.S594983 [doi] PST - epublish SO - Diabetes Metab Syndr Obes. 2026 May 29;19:594983. doi: 10.2147/DMSO.S594983. eCollection 2026. PMID- 42244490 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 1552-3799 (Electronic) IS - 1054-7738 (Linking) VI - 35 IP - 6 DP - 2026 Jul TI - Breastfeeding Counseling Protocol During Hospitalization of Mother/Infant Dyads in Rooming-in: A Methodological Development Study. PG - 291-299 LID - 10.1177/10547738261451530 [doi] AB - Breastfeeding counseling is an effective public health intervention. However, there is a scarcity of studies detailing protocols, especially those applied during the dyad's stay in the Rooming-In Unit. Thus, this research aimed to describe a breastfeeding counseling protocol during the dyad's hospitalization in Rooming-in. A methodological development study was carried out from June to September 2022 in four stages: discovering from a bibliographical survey; defining the target audience, contexts, and answers to the research question; developing from the construction of the instrument; and delivering the final product after content validation by eight experts. The intervention components protocol includes items necessary for execution; intervention script; breastfeeding assessment instrument; adverse situations, solutions, and initial difficulties in breastfeeding; and counseling approach in the face of situations. For each item of the protocol, a Likert scale was applied, and the Content Validity Index was calculated to verify the agreement between the experts. Items with agreement above 80% were considered valid. Content validation was performed in a single evaluation round. The final version of the protocol consisted of 11 sections. It describes in detail the necessary conditions, expected and unexpected procedures, and how to intervene using the counseling approach in the initial difficulties presented during the hospitalization of the dyad in Rooming-in. FAU - Ruiz, Mariana Torreglosa AU - Ruiz MT AUID- ORCID: 0000-0002-5199-7328 AD - Federal University of Triangle Mineiro, Uberaba, Brazil. FAU - Rodrigues, Elisa da Conceicao AU - Rodrigues EDC AUID- ORCID: 0000-0001-6131-8272 AD - Anna Nery School of Nursing, Rio de Janeiro, Brazil. FAU - Peixoto Oliveira da Silva, Karine Emanuelle AU - Peixoto Oliveira da Silva KE AUID- ORCID: 0000-0002-1189-1107 AD - State University of Feira de Santana, Brazil. FAU - Viana de Resende, Cynthya AU - Viana de Resende C AUID- ORCID: 0000-0003-1203-2504 AD - Federal University of Triangle Mineiro, Uberaba, Brazil. FAU - Cavalcanti, Michele Curcino AU - Cavalcanti MC AUID- ORCID: 0000-0002-8607-8081 AD - Anna Nery School of Nursing, Rio de Janeiro, Brazil. FAU - Marques Dos Santos, Luciano AU - Marques Dos Santos L AUID- ORCID: 0000-0001-7866-6353 AD - State University of Feira de Santana, Brazil. FAU - Wernet, Monika AU - Wernet M AD - University of Sao Carlos, Brazil. FAU - Gomes, Ana Leticia Monteiro AU - Gomes ALM AUID- ORCID: 0000-0001-6220-5261 AD - Anna Nery School of Nursing, Rio de Janeiro, Brazil. FAU - Christoffel, Marialda Moreira AU - Christoffel MM AUID- ORCID: 0000-0002-4037-8759 AD - Federal University of Rio de Janeiro, Macae, Brazil. FAU - Raponi, Maria Beatriz Guimaraes AU - Raponi MBG AUID- ORCID: 0000-0003-4487-9232 AD - Federal University of Uberlandia, Brazil. FAU - Aparecida da Silva, Jessica AU - Aparecida da Silva J AUID- ORCID: 0000-0002-4308-5978 AD - Federal University of Triangle Mineiro, Uberaba, Brazil. FAU - Faria de Oliveira, Jacqueline AU - Faria de Oliveira J AUID- ORCID: 0000-0002-2829-1837 AD - Federal University of Triangle Mineiro, Uberaba, Brazil. FAU - Contim, Divanice AU - Contim D AUID- ORCID: 0000-0001-5213-1465 AD - Federal University of Triangle Mineiro, Uberaba, Brazil. FAU - Linares, Ana Maria AU - Linares AM AD - University of Kentucky, Lexington, USA. LA - eng PT - Journal Article DEP - 20260605 PL - United States TA - Clin Nurs Res JT - Clinical nursing research JID - 9208508 SB - IM MH - *Breast Feeding MH - Humans MH - *Counseling/methods MH - Female MH - *Hospitalization MH - *Rooming-in Care MH - Infant MH - *Mothers/psychology MH - Infant, Newborn MH - Surveys and Questionnaires OTO - NOTNLM OT - breastfeeding OT - clinical protocol OT - counseling OT - education OT - guideline OT - methods COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/06/05 06:36 MHDA- 2026/07/01 18:34 CRDT- 2026/06/05 04:33 PHST- 2026/07/01 18:34 [medline] PHST- 2026/06/05 06:36 [pubmed] PHST- 2026/06/05 04:33 [entrez] AID - 10.1177/10547738261451530 [doi] PST - ppublish SO - Clin Nurs Res. 2026 Jul;35(6):291-299. doi: 10.1177/10547738261451530. Epub 2026 Jun 5. PMID- 42244362 OWN - NLM STAT- Publisher LR - 20260622 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) DP - 2026 Jun 5 TI - Association of lifestyle behaviours and socio-economic disparities with overweight and obesity among school-aged children and adolescents: a population-based cross-sectional study. PG - 1-14 LID - 10.1017/S0007114526107715 [doi] AB - This population-based cross-sectional study investigated the associations of sleep, nutrition and physical activity with overweight and obesity among 4108 school-aged children and adolescents (9-17 years) in Punjab, Pakistan, alongside 3371 parental responses. BMI was calculated using anthropometric measurements, and weight status was classified according to the 2007 WHO growth reference. Socio-economic status was determined through parental education, occupation and household income, while lifestyle behaviours were assessed via validated questionnaires. Multivariate logistic regression analyses were conducted, adjusting for sex, grade and socio-economic variables. The prevalence of overweight and obesity was 19.4 % and 10.7 %, respectively. Girls had a higher obesity prevalence than boys (12.3 % v. 8.9 %), whereas boys showed a higher combined prevalence of overweight and obesity. Among boys, obesity was significantly associated with urban residence (adjusted OR (aOR) 1.37; 95 % CI 1.13, 1.83), being an only child (aOR 2.74; 95 % CI 1.92, 3.92), frequent fast-food consumption (>/= 3 times/week; aOR 1.56; 95 % CI 1.23, 1.97) and lower parental education (aOR 1.22; 95 % CI 1.05, 1.41). Among girls, long weekend sleep duration increased obesity risk (aOR 1.38; 95 % CI 1.14, 1.67), while being an only child (aOR 0.36; 95 % CI 0.25, 0.52), frequent fast-food consumption (aOR 0.64; 95 % CI 0.50, 0.80) and lower parental education (aOR 0.81; 95 % CI 0.70, 0.94) were linked to lower odds. Physical activity and soft drink intake were not significant after adjustment. These findings underscore complex, gender-specific relationships between lifestyle and socio-economic factors, highlighting the need for targeted interventions promoting healthy sleep, nutrition and equity-focused strategies. FAU - Tanveer, Moazzam AU - Tanveer M AD - School of Physical Education and Sport Training, https://ror.org/0056pyw12Shanghai University of Sport, Shanghai, People's Republic of China. AD - Department of Allied Health Sciences, https://ror.org/02a37xs76Health Services Academy, Islamabad, Pakistan. AD - School of Health Professionals' Education Research & Entrepreneurship, https://ror.org/02a37xs76Health Services Academy, Islamabad, Pakistan. FAU - Alsabih, Ahmed Othman AU - Alsabih AO AD - Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia. FAU - Cai, Yujun AU - Cai Y AD - School of Physical Education and Sport Training, https://ror.org/0056pyw12Shanghai University of Sport, Shanghai, People's Republic of China. FAU - Alsharidah, Ashwag Saleh AU - Alsharidah AS AD - Department of Physiology, College of Medicine, Qassim University, Buraydah, Saudi Arabia. FAU - Badicu, Georgian AU - Badicu G AD - Department of Physical Education and Special Motricity, Faculty of Physical Education and Mountain Sports, Transilvania University of Brasov, Brasov, Romania. FAU - Asghar, Ejaz AU - Asghar E AD - Department of Allied Health Sciences, https://ror.org/02a37xs76Health Services Academy, Islamabad, Pakistan. AD - School of Health Professionals' Education Research & Entrepreneurship, https://ror.org/02a37xs76Health Services Academy, Islamabad, Pakistan. FAU - Tanveer, Umar AU - Tanveer U AD - School of Allied Health Sciences, The University of Lahore, Lahore, Pakistan. FAU - Roy, Nadeem AU - Roy N AD - School of Physical Education, Shanxi University, Taiyuan, People's Republic of China. FAU - Albaridi, Najla A AU - Albaridi NA AD - Department of Health Science, College of Health and Rehabilitation, Princess Noura bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alsharari, Zayed D AU - Alsharari ZD AD - Department of Health Rehabilitation Sciences, Faculty of Applied Medical Sciences, University of Tabuk, Tabuk, Saudi Arabia. FAU - Saraiva, Ariana AU - Saraiva A AD - Research in Veterinary Medicine (I-MVET), Faculty of Veterinary Medicine, Lisbon University Centre, Lusofona University, Lisboa, Portugal. AD - Veterinary and Animal Research Centre (CECAV), Faculty of Veterinary Medicine, Lisbon University Centre, Lusofona University, Lisboa, Portugal. FAU - Raposo, Antonio AU - Raposo A AUID- ORCID: 0000-0002-5286-2249 AD - CBIOS (Research Center for Biosciences and Health Technologies), ECTS (School of Health Sciences and Technologies), https://ror.org/05xxfer42Lusofona University, Lisboa, Portugal. LA - eng PT - Journal Article DEP - 20260605 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM OTO - NOTNLM OT - Childhood obesity OT - Nutrition OT - Physical activity OT - Sleep OT - Socio-economic status EDAT- 2026/06/05 06:36 MHDA- 2026/06/05 06:36 CRDT- 2026/06/05 03:13 PHST- 2026/06/05 06:36 [pubmed] PHST- 2026/06/05 06:36 [medline] PHST- 2026/06/05 03:13 [entrez] AID - S0007114526107715 [pii] AID - 10.1017/S0007114526107715 [doi] PST - aheadofprint SO - Br J Nutr. 2026 Jun 5:1-14. doi: 10.1017/S0007114526107715. PMID- 42244291 OWN - NLM STAT- MEDLINE DCOM- 20260610 LR - 20260813 IS - 1672-7347 (Print) IS - 1672-7347 (Linking) VI - 51 IP - 3 DP - 2026 Mar 28 TI - Risk factors and interaction analysis of severe diastasis recti abdominis within 6 months postpartum. PG - 459-469 LID - 1672-7347(2026)03-0459-11 [pii] LID - 10.11817/j.issn.1672-7347.2026.250611 [doi] AB - OBJECTIVES: Severe diastasis recti abdominis (DRA) in the postpartum period may lead to long‑term functional impairment in women. However, the independent effects and interactions of perinatal risk factors during the early postpartum recovery window have not been fully elucidated. This study aims to analyze the risk factors and interaction effects associated with severe postpartum DRA and to identify characteristics of high‑risk populations. METHODS: This retrospective cohort study included postpartum women who underwent postpartum rehabilitation treatment at Hengyang Maternal and Child Health Hospital between January 2019 and August 2022, with a postpartum interval of 42 to 180 d. The inter-rectus distance was measured using palpation combined with caliper assessment. According to the inter-rectus distance, participants were divided into 4 groups: A severe DRA group (separation distance >/=4 cm), a moderate DRA group (3.0 to 3.9 cm), a mild DRA group (2.0 to 2.9 cm), and a normal group (<2 cm). The moderate DRA, mild DRA, and normal groups were combined as the control group. Receiver operating characteristic (ROC) curve analysis was used to evaluate continuous variables and determine optimal cutoff values for stratification. The chi-square test was used to compare differences in influencing factors between the severe DRA group and the control group. Binary Logistic regression analysis was further performed to investigate the effects of various factors on severe DRA, and interaction analysis within the binary Logistic regression model was used to identify high-risk populations. RESULTS: A total of 525 postpartum women were ultimately included, including 112 in the severe DRA group, 257 in the moderate DRA group, 98 in the mild DRA group, and 58 in the normal group. The overall incidence of DRA was 89.0%, while the incidence of severe DRA was 21.3%. The diagnostic cutoff values for body mass index (BMI), neonatal birth weight, and gestational weight gain were 22.55 kg/m(2), 3 350 g, and 12.25 kg, respectively. Participants with BMI >/=22.55 kg/m(2), neonatal birth weight >/=3 350 g, gestational weight gain >/=12.25 kg, multiparity, cesarean delivery, or number of fetuses >/=2 had significantly higher incidences of severe DRA (all P<0.05). Binary Logistic regression analysis showed that neonatal birth weight >/=3 350 g, gestational weight gain >/=12.25 kg, cesarean delivery, and multiparity were independent risk factors for severe DRA (all P<0.05). The interaction among neonatal birth weight >/=3 350 g, multiparity, and cesarean delivery showed the strongest association with severe DRA (OR=7.10, 95% CI 3.43 to 14.71). When all 3 risk factors were present simultaneously, the incidence of severe DRA reached 61.76%. CONCLUSIONS: Neonatal birth weight >/=3 350 g, gestational weight gain >/=12.25 kg, cesarean delivery, and multiparity are important independent risk factors for severe postpartum DRA, and significant synergistic amplification effects exist among these factors. This study clarified the characteristics of high-risk populations and may provide a basis for targeted early screening and intervention. FAU - Shan, Hongjie AU - Shan H AD - Department of Nursing, Hengyang Maternal and Child Health Hospital, Hengyang 421001. 1527233421@qq.com. FAU - Xiao, Min AU - Xiao M AD - Department of Emergency, Hengyang Maternal and Child Health Hospital, Hengyang 421001. FAU - Chen, Chao AU - Chen C AD - Quality Management Office, Hengyang Maternal and Child Health Hospital, Hengyang 421001. FAU - Gao, Hong AU - Gao H AD - Department of Scientific Research, Second Affiliated Hospital, University of South China, Hengyang 421001, China. gaoh988@qq.com. LA - eng GR - 2024JJ7069/the Natural Science Foundation of Hunan Province, China/ PT - Journal Article PL - China TA - Zhong Nan Da Xue Xue Bao Yi Xue Ban JT - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences JID - 101230586 SB - IM MH - Humans MH - Female MH - Risk Factors MH - Retrospective Studies MH - *Postpartum Period MH - Pregnancy MH - Adult MH - *Rectus Abdominis/physiopathology MH - *Diastasis, Muscle/etiology/epidemiology MH - Gestational Weight Gain MH - *Puerperal Disorders PMC - PMC13229952 OTO - NOTNLM OT - 6 months postpartum OT - cesarean section OT - diastasis recti abdominis OT - interaction effects OT - multiparity OT - risk factors COIS- The authors declare that they have no conflicts of interest to disclose. EDAT- 2026/06/05 06:36 MHDA- 2026/06/11 05:41 PMCR- 2026/03/28 CRDT- 2026/06/05 02:43 PHST- 2026/06/11 05:41 [medline] PHST- 2026/06/05 06:36 [pubmed] PHST- 2026/06/05 02:43 [entrez] PHST- 2026/03/28 00:00 [pmc-release] AID - 1672-7347(2026)03-0459-11 [pii] AID - 1672-7347（2026）03-0459-11 [pii] AID - 10.11817/j.issn.1672-7347.2026.250611 [doi] PST - ppublish SO - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2026 Mar 28;51(3):459-469. doi: 10.11817/j.issn.1672-7347.2026.250611. PMID- 42243691 OWN - NLM STAT- MEDLINE DCOM- 20260809 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jun 4 TI - A Bayesian multilevel joint model for predicting neonatal head circumference and body mass index: a case study in Dalahu County, Iran. LID - 10.1186/s12884-026-09377-7 [doi] LID - 862 AB - BACKGROUND: Newborn anthropometry is an essential research tool for assessing newborn growth and studying the factors that influence inadequate or excessive fetal growth. Newborn Body Mass Index (BMI) and Head Circumference (HC) are among the anthropometric measurements that are important to monitor from early infancy. This study aimed to identify the maternal, paternal, and pregnancy-related factors associated with newborn BMI and HC in Dalahoo County, Iran. METHODS: This retrospective cohort study included all pregnant women who attended primary health centers in Dalahoo County, located in the central regions of the western half of Kermanshah Province, Iran, from March 21, 2022, to May 19, 2024. The response variables included newborn HC as a continuous variable and newborn BMI as an ordinal variable. BMI was categorized based on sex-and age-specific reference values provided by World Health Organization (WHO). Newborn BMI and HC were examined concurrently to assess factors influencing newborn development using a Bayesian multilevel joint modeling approach. RESULTS: For each additional week of gestation, the odds of being in a higher BMI category increased (OR 1.45; 95% HPD 1.31-1.65). Newborns with smoking fathers had lower odds of being in a higher BMI category than those with non-smoking fathers (OR 0.41; 95% HPD 0.36-0.47). Newborns of mothers with Gestational Diabetes Mellitus (GDM) had higher odds of being in a higher BMI category than those of non-diabetic mothers (OR 2.56; 95% HPD 2.18-2.92). Male newborns had higher odds of being in a higher BMI category than females (OR 1.40; 95% HPD 1.22-1.60). For head circumference, each additional week of gestation increased the mean by 0.44 cm (posterior mean, 0.44; 95% HPD, 0.42-0.45). Male newborns had a larger mean head circumference (posterior mean difference, 0.24 cm; 95% HPD, 0.05-0.38). All associations were interpreted while holding other variables constant. CONCLUSIONS: In this cohort study, gestational age (per week), Gestational Diabetes Mellitus (GDM), and male sex were associated with higher odds of being in a higher newborn BMI category, whereas paternal smoking was associated with lower odds. Gestational age and male sex were associated with a larger mean Head Circumference (HC). Joint modeling of BMI and HC within a Bayesian multilevel framework allowed simultaneous estimation of both outcomes while accounting for outcome correlation, supporting the assessment of BMI and HC together in newborn growth. However, given the limitations of external validity, these findings should be interpreted with caution and are not intended as direct clinical recommendations. CI - (c) 2026. The Author(s). FAU - Fallah, Sahar AU - Fallah S AD - Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Andayeshgar, Bahare AU - Andayeshgar B AD - Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Amini, Payam AU - Amini P AD - School of Medicine, Keele University, Keele, Staffordshire, UK. FAU - Mahaki, Behzad AU - Mahaki B AD - Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. AD - Health Data Science Research Center, Health Research Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. FAU - Shahsavari, Soodeh AU - Shahsavari S AD - Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. soodeh_shahsavari@yahoo.com. AD - Health Data Science Research Center, Health Research Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran. soodeh_shahsavari@yahoo.com. FAU - Hashemian, Amir Hossein AU - Hashemian AH AD - Department of Biostatistics, School of Health, Kermanshah University of Medical Sciences, Kermanshah, Iran. dr.ahashemian@gmail.com. FAU - Fournier, Andrew AU - Fournier A AD - College of Doctoral Studies, Grand Canyon University, Phoenix, AZ, USA. LA - eng PT - Journal Article DEP - 20260604 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Bayes Theorem MH - Iran MH - *Body Mass Index MH - Infant, Newborn MH - Retrospective Studies MH - Pregnancy MH - *Head/anatomy & histology MH - Male MH - *Cephalometry/methods MH - Adult MH - Gestational Age MH - Smoking/epidemiology PMC - PMC13455485 OTO - NOTNLM OT - Bayesian Joint Model OT - Body Mass Index OT - Head Circumference OT - Multilevel OT - Random Intercept COIS- Declarations. Ethics approval and consent to participate: Approved by the ethics committee of Kermanshah University of Medical Sciences (ID: IR.KUMS.REC.1402.034). Participant confidentiality was maintained; informed consent was obtained. Procedures adhered to the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/05 00:35 MHDA- 2026/08/10 00:40 PMCR- 2026/06/04 CRDT- 2026/06/04 23:55 PHST- 2025/09/16 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/08/10 00:40 [medline] PHST- 2026/06/05 00:35 [pubmed] PHST- 2026/06/04 23:55 [entrez] PHST- 2026/06/04 00:00 [pmc-release] AID - 10.1186/s12884-026-09377-7 [pii] AID - 9377 [pii] AID - 10.1186/s12884-026-09377-7 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jun 4;26(1):862. doi: 10.1186/s12884-026-09377-7. PMID- 42243577 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261015 IS - 1437-1596 (Electronic) IS - 0937-9827 (Print) IS - 0937-9827 (Linking) VI - 140 IP - 6 DP - 2026 Nov TI - Improving reliability of permanent tooth staging for dental age estimation using the crown-root ratio method. PG - 3993-4001 LID - 10.1007/s00414-026-03861-7 [doi] AB - OBJECTIVE: Root staging for dental age estimation is subjective when no standard reference is available. This study developed a quantitative approach for Moorrees root stages (R1/4, R1/2, R3/4 and Rc) using crown-root ratio (CRR) measurements and stage-specific bounds. MATERIALS AND METHODS: The development phase included 269 Malaysian subjects (145 males, 124 females) aged 16-25 years. A total of 1,502 mature permanent mandibular left teeth (I1-M3) were measured on panoramic radiographs using ImageJ software to determine mean CRR values for mature roots (Rc), the fraction stages and stage-specific bounds, where [Formula: see text], [Formula: see text], and lower bound=succeeding stage CRR + 0.01. Sex differences were analysed using independent t-tests. Validation used 161 additional radiographs (78 males, 83 females) aged 3-24 years, with 774 developing and mature permanent mandibular left teeth measured and independently staged according to Moorrees' method. Measured CRR values were compared with stage-specific bounds and considered accurate when within the expected range. Accuracy was calculated as: [Formula: see text]. RESULTS: Mean CRR values ranged from 0.50 to 0.82, with M3 showing the greatest variability. Significant sex differences were observed for C, P1, M1 and M2 (p < 0.05). Overall staging accuracy was 89.9% (84.6%-95.7%) and declined progressively from R1/4 to Rc. M3 (95.7%) and C (91.3%) showed the highest accuracy, whereas I1 (85.7%) and M1 (88.0%) showed the lowest. CONCLUSION: The CRR method provides an objective approach for defining Moorrees root stages and improving staging consistency. CI - (c) 2026. The Author(s). FAU - Abdul Rahim, Amir H AU - Abdul Rahim AH AUID- ORCID: 0000-0002-9085-0804 AD - Department of Oral and Maxillofacial Clinical Sciences, Faculty of Dentistry, Universiti Malaya, Kuala Lumpur, Malaysia. amirhazwan@um.edu.my. AD - Dental Institute, Queen Mary University of London, London, UK. amirhazwan@um.edu.my. FAU - Davies, Janet A AU - Davies JA AD - Dental Institute, Queen Mary University of London, London, UK. FAU - Liversidge, Helen M AU - Liversidge HM AD - Dental Institute, Queen Mary University of London, London, UK. LA - eng PT - Journal Article DEP - 20260605 PL - Germany TA - Int J Legal Med JT - International journal of legal medicine JID - 9101456 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Adolescent MH - *Tooth Root/diagnostic imaging/growth & development MH - Female MH - Male MH - *Tooth Crown/diagnostic imaging/growth & development MH - Young Adult MH - Radiography, Panoramic MH - Reproducibility of Results MH - Adult MH - *Dentition, Permanent MH - Child MH - Child, Preschool PMC - PMC13658346 OTO - NOTNLM OT - Crown-root ratio OT - Dental age estimation OT - Moorrees technique OT - Quantitative method OT - Reliability OT - Root staging COIS- Declarations. Ethics approval: Ethics approval was granted by the Medical Ethics Committee, Faculty of Dentistry (IRB Reference Number: DF OS 1909/0042(P)). All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008 (5). Human ethics and consent to participate: Participants were informed of the potential use of their radiological data for teaching and research purposes, and written consent was obtained from the participants (or their parent or legal guardian in the case of children under 16). Clinical trial number: Not applicable. Financial interests: The authors have no relevant financial or non-financial interests to disclose. Competing interests: The authors declare no competing interests. EDAT- 2026/06/05 00:35 MHDA- 2026/10/12 17:30 PMCR- 2026/06/05 CRDT- 2026/06/04 23:37 PHST- 2026/03/25 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/10/12 17:30 [medline] PHST- 2026/06/05 00:35 [pubmed] PHST- 2026/06/04 23:37 [entrez] PHST- 2026/06/05 00:00 [pmc-release] AID - 10.1007/s00414-026-03861-7 [pii] AID - 3861 [pii] AID - 10.1007/s00414-026-03861-7 [doi] PST - ppublish SO - Int J Legal Med. 2026 Nov;140(6):3993-4001. doi: 10.1007/s00414-026-03861-7. Epub 2026 Jun 5. PMID- 42243551 OWN - NLM STAT- MEDLINE DCOM- 20260605 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 7 DP - 2026 Jun 4 TI - Hepatic steatosis in pediatric obesity: association with cardiometabolic profile and considerations regarding alanine aminotransferase screening. LID - 468 [pii] LID - 10.1007/s00431-026-07132-w [doi] AB - PURPOSE: Hepatic steatosis is the most common chronic liver disease in children with obesity and is associated with an adverse cardiometabolic profile. This study aimed to estimate the prevalence of cardiometabolic risk factors and ultrasound-guided attenuation parameter (UGAP)-diagnosed hepatic steatosis in children with obesity, evaluate variables associated with steatosis, and explore the diagnostic performance of alanine aminotransferase (ALT). METHODS: This single-center, cross-sectional study included 91 children aged >/= 9 years with obesity recruited from pediatric endocrinology and gastroenterology outpatient clinics between July 2023 and July 2025. Anthropometric, blood pressure, biochemical, and UGAP measurements were collected. Hepatic steatosis was defined as UGAP >/= 0.680 dB/cm/MHz. Elevated ALT was defined as >/= 44 U/L in females and >/= 52 U/L in males. Associations with hepatic steatosis were assessed using Poisson regression. RESULTS: The prevalence of UGAP-diagnosed hepatic steatosis was 28.6%. Higher BMI z-score, larger waist circumference, elevated ALT, arterial hypertension, dyslipidemia, insulin resistance, and metabolic syndrome were significantly associated with hepatic steatosis. Elevated ALT showed low sensitivity (19.2%) and high specificity (93.8%) for detecting hepatic steatosis. ALT discriminatory performance differed by sex, with an AUC of 0.816 in females and 0.582 in males. Exploratory ALT cutoffs showed limited clinical applicability, particularly in males because of very low specificity. CONCLUSION: Children with obesity and UGAP-diagnosed hepatic steatosis showed a more unfavorable cardiometabolic profile. ALT alone may miss a substantial proportion of children with hepatic steatosis, supporting the need for improved screening strategies. WHAT IS KNOWN: * Pediatric hepatic steatosis is associated with an adverse cardiometabolic profile in children with obesity. * Screening strategies based on ALT and imaging techniques show variable diagnostic performance in pediatric populations. WHAT IS NEW: * UGAP-diagnosed hepatic steatosis in children with obesity was associated with an unfavorable cardiometabolic profile in a Spanish secondary-care cohort. * ALT showed sex-specific differences and limited usefulness as a standalone screening tool for hepatic steatosis, particularly in males, when UGAP was used as the reference method. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Recio Linares, Aranzazu AU - Recio Linares A AUID- ORCID: 0000-0003-2794-1719 AD - 1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Hospital Universitario Fundacion de Alcorcon, Madrid, Spain. aranzazu.recio@salud.madrid.org. FAU - Botija, Gonzalo AU - Botija G AD - 1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Hospital Universitario Fundacion de Alcorcon, Madrid, Spain. FAU - Bezanilla Lopez, Carolina AU - Bezanilla Lopez C AD - 2Division of Pediatric Endocrinology, Department of Pediatrics, Hospital Universitario Fundacion de Alcorcon, Madrid, Spain. FAU - Barasoain Millan, Alberto AU - Barasoain Millan A AD - 2Division of Pediatric Endocrinology, Department of Pediatrics, Hospital Universitario Fundacion de Alcorcon, Madrid, Spain. FAU - Del Olmo Segura, Patricia AU - Del Olmo Segura P AD - 1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Hospital Universitario Fundacion de Alcorcon, Madrid, Spain. FAU - Ferreo Santos, Paula AU - Ferreo Santos P AD - 1Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Hospital Universitario Fundacion de Alcorcon, Madrid, Spain. FAU - Cano Dorao, Fidel Cano AU - Cano Dorao FC AD - 3Department of Radiology, Hospital Universitario Fundacion de Alcorcon, Madrid, Spain. FAU - Gonzalez-Hoyuela, Maritza AU - Gonzalez-Hoyuela M AD - 3Department of Radiology, Hospital Universitario Fundacion de Alcorcon, Madrid, Spain. FAU - Carrero Alvaro, Juan Carrero AU - Carrero Alvaro JC AD - 3Department of Radiology, Hospital Universitario Fundacion de Alcorcon, Madrid, Spain. FAU - Garcia Hernando, Thais AU - Garcia Hernando T AD - 3Department of Radiology, Hospital Universitario Fundacion de Alcorcon, Madrid, Spain. FAU - Perez Fernandez, Elia Perez AU - Perez Fernandez EP AD - 4Research Unit, Hospital Universitario Fundacion de Alcorcon, Madrid, Spain. LA - eng PT - Journal Article DEP - 20260604 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - EC 2.6.1.2 (Alanine Transaminase) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Male MH - Child MH - Cross-Sectional Studies MH - *Alanine Transaminase/blood MH - *Fatty Liver/epidemiology/diagnosis/etiology/blood MH - *Pediatric Obesity/complications MH - Ultrasonography MH - Prevalence MH - Cardiometabolic Risk Factors MH - Adolescent MH - Metabolic Syndrome/epidemiology MH - Sensitivity and Specificity MH - Risk Factors MH - Biomarkers/blood OTO - NOTNLM OT - Alanine Aminotransferase OT - Fatty Liver OT - Metabolic Syndrome OT - Pediatric Obesity OT - Risk Factors OT - Ultrasonography COIS- Declarations. Ethics approval: The study was approved by the Clinical Research Ethics Committee of Hospital Universitario Fundacion de Alcorcon (approval number: 23/102). All procedures were performed in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments. Informed consent was obtained from the children's parents or guardians before enrolment. Conflicts of interest: The authors declare no competing interests. EDAT- 2026/06/05 00:35 MHDA- 2026/06/06 00:35 CRDT- 2026/06/04 23:36 PHST- 2026/04/04 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/05/22 00:00 [revised] PHST- 2026/06/06 00:35 [medline] PHST- 2026/06/05 00:35 [pubmed] PHST- 2026/06/04 23:36 [entrez] AID - 10.1007/s00431-026-07132-w [pii] AID - 10.1007/s00431-026-07132-w [doi] PST - epublish SO - Eur J Pediatr. 2026 Jun 4;185(7):468. doi: 10.1007/s00431-026-07132-w. PMID- 42242500 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 74 DP - 2026 Aug TI - Development and internal validation of a bioimpedance-based predictive model for assessing fat-free mass in infants, children and adolescents: Accuracy meets practicality. PG - 103367 LID - S2405-4577(26)00463-8 [pii] LID - 10.1016/j.clnesp.2026.103367 [doi] AB - BACKGROUND AND AIMS: Accurate evaluation of body composition in infants, children and adolescents is essential for monitoring growth and nutritional status. Reference methods such as air displacement plethysmography (ADP) and dual-energy X-ray absorptiometry (DXA) offer high accuracy but are costly and limited to specialized settings. Bioelectrical impedance analysis (BIA) provides a portable, non-invasive alternative; however, predictive equations for estimating fat-free mass (FFM) in pediatric populations require further validation. Considering this, our study aimed to develop and validate a BIA-based predictive model for estimating FFM in healthy subjects from birth to 18 years, using ADP as reference method. METHODS: An exploratory cross-sectional study was conducted on 142 participants (86 aged 0-1 year; 56 aged 2-18 years). Anthropometric and bioelectrical impedance parameters were collected following standardized protocols. Participants were randomly assigned to training (70%) and validation (30%) cohorts. Multiple linear regression models incorporating weight, length/height, sex, and impedance variables were tested. Model performance was evaluated using adjusted R(2) and root mean square error (RMSE); agreement with ADP-derived FFM was assessed through Bland-Altman analysis. RESULTS: In both age groups, models including impedance-index outperformed anthropometry-only models. The best model (weight + sex + impedance index [L(2)/R(50)]) achieved excellent predictive accuracy (0-1 year: adjusted R(2) = 0.953, RMSE = 0.183 kg; 2-18 years: adjusted R(2) = 0.987, RMSE = 1.409 kg). Bland-Altman analysis showed minimal bias and narrow limits of agreement. CONCLUSIONS: the proposed developed BIA-based equation provides a practical, reliable, and highly accurate tool for estimating FFM across pediatric ages, supporting its potential application in clinical practice. However, the present findings are based on an internal validation using a split-sample strategy, and external validation in independent cohorts is warranted to confirm the generalizability of the proposed equation. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Perrone, Michela AU - Perrone M AD - NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. FAU - Roggero, Paola AU - Roggero P AD - NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. Electronic address: paola.roggero@unimi.it. FAU - Nicora, Arianna AU - Nicora A AD - NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. FAU - Torcasio, Benedetta AU - Torcasio B AD - NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. FAU - Pesenti, Nicola AU - Pesenti N AD - Division of Biostatistics, Epidemiology, and Public Health, Department of Statistics and Quantitative Methods, University of Milano-Bicocca, Milan, Italy. FAU - Tabasso, Chiara AU - Tabasso C AD - NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. FAU - Fumagalli, Monica AU - Fumagalli M AD - NICU, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy; Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, Universita degli Studi di Milano, 20122 Milan, Italy. LA - eng PT - Journal Article PT - Validation Study DEP - 20260603 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM MH - Humans MH - Adolescent MH - *Electric Impedance MH - Child MH - Child, Preschool MH - Female MH - Male MH - *Body Composition MH - Infant MH - Cross-Sectional Studies MH - Reproducibility of Results MH - Absorptiometry, Photon MH - Anthropometry MH - Infant, Newborn MH - Nutritional Status MH - Linear Models OTO - NOTNLM OT - Bioimpedance OT - Body composition OT - Growth OT - Nutritional status COIS- Declaration of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/05 00:34 MHDA- 2026/06/27 00:57 CRDT- 2026/06/04 19:35 PHST- 2025/11/24 00:00 [received] PHST- 2026/04/24 00:00 [revised] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/06/27 00:57 [medline] PHST- 2026/06/05 00:34 [pubmed] PHST- 2026/06/04 19:35 [entrez] AID - S2405-4577(26)00463-8 [pii] AID - 10.1016/j.clnesp.2026.103367 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2026 Aug;74:103367. doi: 10.1016/j.clnesp.2026.103367. Epub 2026 Jun 3. PMID- 42239493 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260604 LR - 20260813 IS - 2468-0249 (Electronic) IS - 2468-0249 (Linking) VI - 11 IP - 7 DP - 2026 Jul TI - AKI and Mortality in Children Hospitalized With Malnutrition. PG - 106564 LID - 10.1016/j.ekir.2026.106564 [doi] LID - 106564 AB - INTRODUCTION: Acute kidney injury (AKI) is a common complication of pediatric hospitalizations. We evaluated the prevalence of AKI in children hospitalized with acute malnutrition, examined how AKI definitions influence risk stratification, and assessed the performance of the STOP AKI risk score. METHODS: We enrolled 185 Ugandan children hospitalized with acute malnutrition. AKI was defined using the Kidney Disease: Improving Global Outcomes (KDIGO) criteria based on serial creatinine measurements, with the nadir creatinine during hospitalization as baseline. Because children with malnutrition have low baseline creatinine levels, we evaluated whether applying minimum absolute creatinine thresholds improved identification of clinically meaningful AKI, defined by its association with mortality. RESULTS: The median age was 1.2 years, and 13.5% of children died. KDIGO-defined AKI without a minimum creatinine threshold was not associated with mortality. Applying a minimum absolute creatinine threshold of 0.4 mg/dl to the KDIGO criteria identified AKI in 23.2% of participants and was independently associated with mortality (adjusted odds ratio [OR, aOR]: 4.06, 95% confidence interval [CI]: 1.39-11.84). A threshold of 0.5 mg/dl identified fewer children but predominantly severe AKI. Clinical risk factors included diarrhea, vomiting, and sepsis. The ISN STOP AKI risk score did not discriminate AKI risk (area under the receiver operating characteristic curve [AUROC]: 0.50, 95% CI: 0.40-0.60). CONCLUSION: AKI is common in children hospitalized with acute malnutrition and is strongly associated with mortality when clinically meaningful creatinine thresholds are applied. Existing AKI risk tools perform poorly in this population, thereby underscoring the need for adapted approaches to AKI identification in malnourished children. CI - (c) 2026 The Author(s). FAU - Batte, Anthony AU - Batte A AD - Child Health and Development Center, College of Health Sciences, Makerere University, Kampala, Uganda. AD - Facultat de Medicina i Ciencies de la Salut, Universitat de Barcelona, Barcelona, Spain. AD - Global Health Uganda, Kampala, Uganda. AD - Department of Paediatrics, College of Health Sciences, Makerere University, Kampala, Uganda. FAU - Namugumya, Aidah AU - Namugumya A AD - Department of Paediatrics, College of Health Sciences, Makerere University, Kampala, Uganda. FAU - Hasson, Denise C AU - Hasson DC AD - Hassenfeld Children's Hospital at NYU Langone Health, New York, New York, USA. FAU - Desmarais, Aline AU - Desmarais A AD - Hassenfeld Children's Hospital at NYU Langone Health, New York, New York, USA. FAU - Goings, Michael J AU - Goings MJ AD - Ryan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, Indiana, USA. FAU - Mpimbaza, Arthur AU - Mpimbaza A AD - Child Health and Development Center, College of Health Sciences, Makerere University, Kampala, Uganda. FAU - Babikako, Harriet M AU - Babikako HM AD - Child Health and Development Center, College of Health Sciences, Makerere University, Kampala, Uganda. AD - Child and Family Foundation Uganda, Kampala, Uganda. FAU - Bassat, Quique AU - Bassat Q AD - Facultat de Medicina i Ciencies de la Salut, Universitat de Barcelona, Barcelona, Spain. AD - ISGlobal, Hospital Clinic - Universitat de Barcelona, Barcelona, Spain. AD - Centro de Investigacao em Saude de Manhica, Maputo, Mozambique. AD - ICREA, Pg. Lluis Companys 23, Barcelona, Spain. FAU - Conroy, Andrea L AU - Conroy AL AD - Facultat de Medicina i Ciencies de la Salut, Universitat de Barcelona, Barcelona, Spain. AD - Global Health Uganda, Kampala, Uganda. AD - Ryan White Center for Pediatric Infectious Disease and Global Health, Indiana University School of Medicine, Indianapolis, Indiana, USA. LA - eng PT - Journal Article DEP - 20260422 PL - United States TA - Kidney Int Rep JT - Kidney international reports JID - 101684752 PMC - PMC13227193 OTO - NOTNLM OT - acute kidney injury OT - acute malnutrition OT - children OT - definitions OT - mortality OT - risk score EDAT- 2026/06/04 06:33 MHDA- 2026/06/04 06:34 PMCR- 2026/04/22 CRDT- 2026/06/04 05:40 PHST- 2026/02/18 00:00 [received] PHST- 2026/04/09 00:00 [revised] PHST- 2026/04/13 00:00 [accepted] PHST- 2026/06/04 06:34 [medline] PHST- 2026/06/04 06:33 [pubmed] PHST- 2026/06/04 05:40 [entrez] PHST- 2026/04/22 00:00 [pmc-release] AID - S2468-0249(26)02796-8 [pii] AID - 106564 [pii] AID - 10.1016/j.ekir.2026.106564 [doi] PST - epublish SO - Kidney Int Rep. 2026 Apr 22;11(7):106564. doi: 10.1016/j.ekir.2026.106564. eCollection 2026 Jul. PMID- 42239487 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260604 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Infant gut microbiota following cesarean section in the Middle East: a multidisciplinary expert consensus based on a targeted narrative review. PG - 1809889 LID - 10.3389/fped.2026.1809889 [doi] LID - 1809889 AB - BACKGROUND: Early-life dysbiosis associated with Cesarean section (C-section) delivery is increasingly recognized as a modifiable risk factor influencing short- and long-term health outcomes. This multidisciplinary expert consensus summarizes the clinical implications of C-section on infant gut microbiota. It proposes evidence-based strategies to mitigate these effects, with a focus on the critical window of the first 1,000 days of life. METHODS: A multidisciplinary panel of 16 pediatricians, neonatologists, pediatric gastroenterologists, and nutrition experts conducted a targeted narrative review of the literature to inform a structured expert consensus process and participated in an online structured consensus process. Seventeen consensus statements were developed and validated through discussion, expert voting, and commentary, supported by a targeted review of current scientific evidence. RESULTS: The expert panel reached consensus on the impact of C-section delivery on early microbiota composition and its clinical relevance, emphasizing that the rising prevalence of C-sections worldwide demands urgent attention. Experts unanimously emphasized the importance of exclusive breastfeeding as the primary strategy to support healthy microbiota development in infants born by cesarean section. When exclusive breastfeeding is not possible, evidence-based nutritional approaches, including selected prebiotics and probiotic strains with documented clinical efficacy, are recognized as promising alternatives for supporting microbial balance. Notably, the panel underscored that not all probiotics are equally effective and recommended shifting toward evidence-based strains shown to help restore gut dysbiosis in this population. Also, experts advocated for continuing microbiota-targeted support throughout the first 1,000 days of life, viewing this developmental window as a critical continuum rather than a limited early-life phase, while acknowledging the need for more long-term data. Additionally, education for healthcare professionals and parents about the long-term implications of C-section delivery was emphasized as a key enabler of the broader adoption of eubiosis-targeted strategies. CONCLUSIONS: Optimizing microbial colonization in infants born by cesarean section requires a multifaceted approach that prioritizes breastfeeding, supports judicious use of evidence-based nutritional interventions when needed, and emphasizes education and continuity of care across early life. By aligning clinical practice with emerging microbiome science, early-life interventions may reduce dysbiosis-associated risks and improve long-term health outcomes. CI - (c) 2026 Aldekhail, Al-Beltagi, Indrio, Al-Nemri, Tomerak, Al Sawai, Al-Refaee, Al-Ghanem, Rozi, Alallah, Khan, Abouhazima, Al-Mannaei, El-Atawi, Sleiman and Miqdady. FAU - Aldekhail, Wajeeh AU - Aldekhail W AD - Department of Pediatric Gastroenterology & Hepatology, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia. FAU - Al-Beltagi, Mohammed AU - Al-Beltagi M AD - Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta, Alghrabia, Egypt. AD - Department of Pediatrics, University Hospital, Arabian Gulf University, Manama, Bahrain. FAU - Indrio, Flavia AU - Indrio F AD - Department of Experimental Medicine, University of Salento, Lecce, Italy. FAU - Al-Nemri, Abdulrahman M AU - Al-Nemri AM AD - College of Medicine, King Saud University, Riyadh, Saudi Arabia. AD - Department of Pediatric, King Saud University Medical City, Riyadh, Saudi Arabia. FAU - Tomerak, Ahmed AU - Tomerak A AD - Department of Neonatal Intensive Care Unit, Al Wakra Hospital, Hamad Medical Corporation, Doha, Qatar. FAU - Al Sawai, Ali AU - Al Sawai A AD - Department of Child Health, Royal Hospital, Ministry of Health, Muscat, Oman. FAU - Al-Refaee, Fawaz AU - Al-Refaee F AD - Department of Pediatrics, Al-Adan Hospital, Ministry of Health, Kuwait, Kuwait. FAU - Al-Ghanem, Ghanem AU - Al-Ghanem G AD - Department of Neonatal Perinatal Medicine, Adan Hospital, Ahmadi, Kuwait. FAU - Rozi, Ibrahim Hosamuddin AU - Rozi IH AD - Department of Pediatrics, King Fahd Armed Forces Hospital, Jeddah, Saudi Arabia. FAU - Alallah, Jubara AU - Alallah J AD - Department of Pediatrics, King Abdulaziz Medical City-Jeddah, Ministry of National Guard Health Affairs (MNGHA), Jeddah, Saudi Arabia. AD - College of Medicine-Jeddah, King Saud Bin Abdul Aziz University for Health Sciences (KSAU-HS), Jeddah, Saudi Arabia. AD - King Abdullah International Medical Research Centre (KAIMRC), Ministry of National Guard Health Affairs (MNGHA), Riyadh, Saudi Arabia. FAU - Khan, Junaid Muhib AU - Khan JM AD - Department of Neonatal Intensive Care Unit, Shakhbout Medical City/Mayo Clinics, Abu Dhabi, United Arab Emirates. FAU - Abouhazima, Khaled AU - Abouhazima K AD - Division of Gastroenterology, Hepatology, and Nutrition, Sidra Medicine, Doha, Qatar. FAU - Al-Mannaei, Khaled AU - Al-Mannaei K AD - Department of Paediatrics, Al Salam International Hospital, Dasma, Kuwait. FAU - El-Atawi, Khaled AU - El-Atawi K AD - Department of Pediatrics, Latifa Women and Children Hospital, Dubai, United Arab Emirates. FAU - Sleiman, Rola AU - Sleiman R AD - Al Habib Medical Group, Al Rayyan Hospital, Riyadh, Saudi Arabia. FAU - Miqdady, Mohammed AU - Miqdady M AD - Pediatric Gastroenterology, Hepatology, and Nutrition, Sheikh Khalifa Medical City (SKMC), Abu Dhabi, United Arab Emirates. AD - Pediatric Gastroenterology, Hepatology, and Nutrition, College of Medicine and Health Sciences, Khalifa University, Abu Dhabi, United Arab Emirates. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260519 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13227540 OTO - NOTNLM OT - breastfeeding (BF) OT - cesarean section OT - early-life dysbiosis OT - first 1,000 days OT - gut microbiota OT - probiotics OT - term infant COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. AT was employed by NICU, Al Wakra Hospital, Hamad Medical Corporation. The remaining author(s) declared that that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/04 06:34 MHDA- 2026/06/04 06:35 PMCR- 2026/05/19 CRDT- 2026/06/04 05:40 PHST- 2026/02/12 00:00 [received] PHST- 2026/04/27 00:00 [revised] PHST- 2026/04/29 00:00 [accepted] PHST- 2026/06/04 06:35 [medline] PHST- 2026/06/04 06:34 [pubmed] PHST- 2026/06/04 05:40 [entrez] PHST- 2026/05/19 00:00 [pmc-release] AID - 10.3389/fped.2026.1809889 [doi] PST - epublish SO - Front Pediatr. 2026 May 19;14:1809889. doi: 10.3389/fped.2026.1809889. eCollection 2026. PMID- 42238922 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260604 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Effects of Halliwick-based aquatic exercise on social and motor skills of children with autism spectrum disorder: a pilot study. PG - 1832876 LID - 10.3389/fpsyg.2026.1832876 [doi] LID - 1832876 AB - Limited evidence is available regarding the effects and duration of Halliwick-based aquatic exercise intervention in children with autism spectrum disorder (ASD). This pilot study aimed to investigate the feasibility, initial effects and short-term persistence of Halliwick-based aquatic exercise on social and motor skills in children with ASD. Twelve children with ASD were randomly assigned into either intervention group or control group. Assessments were conducted at baseline (T0), after 6 weeks of intervention (T1), at the end of intervention (T2), and 4 weeks after cessation of the intervention (T3). Outcome measures included balance performance (standing on one leg with eyes open and closed, intensive Romberg tests), the Autism Treatment Evaluation Checklist (ATEC), Children's Autism Rating Scale (CARS), Children's Sensory Integration Rating Scale (CSIS), and the Humphries Assessment of Aquatic Readiness (HAAR). In the intervention group, ATEC health/behavior and total score were significantly reduced at T1 compared to T0, and speech/language/communication scores were significantly lower than those of the control group. CARS scores showed significant reductions at T1, T2, and T3 compared to T0. In contrast, CSIS scores, balance performance and HAAR scores demonstrated significant increases from T1 to T3 compared to both baseline and the control group. This pilot study suggested that a 12-week Halliwick-based aquatic exercise program may be associated with improvements in social and motor skills in children with ASD, with some benefits maintained for at least 4 weeks. Large-scale studies are needed to confirm the preliminary findings. CI - Copyright (c) 2026 Liu, Feng, Zhu, Li, Zhou and Wang. FAU - Liu, Yu AU - Liu Y AD - School of Physical Education, Guangxi University, Nanning, China. FAU - Feng, Junyang AU - Feng J AD - School of Physical Education, Guangxi University, Nanning, China. FAU - Zhu, Yantao AU - Zhu Y AD - School of Physical Education, Guangxi University, Nanning, China. FAU - Li, Chengyang AU - Li C AD - School of Physical Education, Guangxi University, Nanning, China. FAU - Zhou, Yong AU - Zhou Y AD - School of Physical Education, Guangxi University, Nanning, China. FAU - Wang, Xuebing AU - Wang X AD - School of Physical Education, Guangxi University, Nanning, China. LA - eng PT - Journal Article DEP - 20260519 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13226205 OTO - NOTNLM OT - ASD OT - aquatic exercise OT - balance OT - motor skill OT - social interaction COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/04 06:32 MHDA- 2026/06/04 06:33 PMCR- 2026/05/19 CRDT- 2026/06/04 05:33 PHST- 2026/03/17 00:00 [received] PHST- 2026/04/29 00:00 [revised] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/06/04 06:33 [medline] PHST- 2026/06/04 06:32 [pubmed] PHST- 2026/06/04 05:33 [entrez] PHST- 2026/05/19 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1832876 [doi] PST - epublish SO - Front Psychol. 2026 May 19;17:1832876. doi: 10.3389/fpsyg.2026.1832876. eCollection 2026. PMID- 42238837 OWN - NLM STAT- MEDLINE DCOM- 20260610 LR - 20260921 IS - 1319-6138 (Print) IS - 1319-6138 (Electronic) IS - 1319-6138 (Linking) VI - 31 IP - 1 DP - 2026 Jan TI - Identifying Risk Factors for the Rising Prevalence of Multiple Sclerosis in Saudi Arabia: A case-control analysis. PG - 18-25 LID - 10.17712/1658-3183.1002 [doi] AB - OBJECTIVE: This study aims to identify risk factors linked to the increasing prevalence of multiple sclerosis (MS) in Saudi Arabia. Multiple sclerosis is a chronic autoimmune condition affecting the central nervous system, marked by inflammation and damage to nerves and the myelin sheath. METHOD: A case-control study conducted from September 2022 to January 2024 included 832 participants-263 diagnosed with MS and 569 controls. Controls were matched by age, gender, residence, and employment status. Data was collected using a validated questionnaire, with written consent obtained from participants aged 18 and older. Logistic regression analysis was used to ascertain risk factors. RESULTS: Out of 832 participants, 263 (31.6%) were diagnosed with MS. The greatest percentage of MS cases occurred in the 25-34 age range (37.7%). After adjusting for potential confounders, smoking was significantly associated with increased MS risk (AOR = 2.34, 95% CI: [1.22-4.48], p = 0.01), as were vitamin D deficiency (AOR = 1.97, 95% CI: [1.31-2.98], p<0.00), and a history of childhood sexual abuse (AOR = 1.96, 95% CI: [1.11-3.45], p = 0.02). Conversely, vitamin D supplementation was associated with a substantial reduction in MS risk (AOR = 0.17, 95% CI: [0.10-0.28], p < 0.001), as was coffee consumption (AOR = 0.53, 95% CI: [0.30-0.96], p < 0.04). CONCLUSION: Smoking, vitamin D deficiency, and a history of childhood sexual abuse increase MS risk, while vitamin D supplementation and coffee consumption reduce it. Further research is essential to confirm these findings. CI - Copyright: (c) Neurosciences. FAU - Babateen, Omar AU - Babateen O AUID- ORCID: 0000-0002-1341-2616 AD - Department of Physiology, Faculty of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia. FAU - Samkari, Jamil Adnan AU - Samkari JA AUID- ORCID: 0000-0002-4784-3086 AD - Department of Family and Community Medicine, Faculty of Medicine, King Abdulaziz University, Rabigh, Saudi Arabia. FAU - Abdulaziz Alkaki, Rewaa AU - Abdulaziz Alkaki R AD - College of Medicine, Umm Al-Qura University, Makkah, Kingdom of Saudi Arabia. FAU - Ayman Alamri, Sadin AU - Ayman Alamri S AD - College of Medicine, University of Jeddah, Jeddah, Kingdom of Saudi Arabia. FAU - Mutlaq Alzahrani, Manal AU - Mutlaq Alzahrani M AD - College of Medicine, University of Jeddah, Jeddah, Kingdom of Saudi Arabia. FAU - Saleh Alharbi, Mussaed AU - Saleh Alharbi M AD - Department of Internal Medicine, King Fahad Armed Forces Hospital, Jeddah, Kingdom of Saudi Arabia. FAU - Abdulrazaq Alghamdi, Ali AU - Abdulrazaq Alghamdi A AD - College of Medicine, King Faisal University, Al-Ahsa, Kingdom of Saudi Arabia. FAU - Sultan Aljurays, Amwaj AU - Sultan Aljurays A AD - Department of Medicine, Almithnab General Hospital, Qassim, Kingdom of Saudi Arabia. FAU - Faleh Aldosari, Amjad AU - Faleh Aldosari A AD - College of Medicine, Taif University, Taif, Kingdom of Saudi Arabia. FAU - Makkawi, Seraj AU - Makkawi S AUID- ORCID: 0000-0002-0892-8669 AD - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Jeddah, Kingdom of Saudi Arabia. AD - King Abdullah International Medical Research Center, Jeddah, Kingdom of Saudi Arabia. AD - Department of Neurology, Ministry of the National Guard-Health Affairs, Jeddah, Kingdom of Saudi Arabia. LA - eng PT - Journal Article DEP - 20260327 PL - Saudi Arabia TA - Neurosciences (Riyadh) JT - Neurosciences (Riyadh, Saudi Arabia) JID - 101252453 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Risk Factors MH - Female MH - *Multiple Sclerosis/epidemiology MH - Male MH - Case-Control Studies MH - Adult MH - Prevalence MH - Middle Aged MH - Young Adult MH - Smoking/epidemiology MH - Vitamin D Deficiency/epidemiology MH - Adolescent PMC - PMC13169298 OTO - NOTNLM OT - Case-control study OT - Multiple sclerosis OT - Prevalence OT - Risk factors OT - Saudi Arabia EDAT- 2026/06/04 06:35 MHDA- 2026/06/11 05:40 PMCR- 2026/01/01 CRDT- 2026/06/04 05:32 PHST- 2025/04/13 00:00 [received] PHST- 2025/09/09 00:00 [accepted] PHST- 2026/06/11 05:40 [medline] PHST- 2026/06/04 06:35 [pubmed] PHST- 2026/06/04 05:32 [entrez] PHST- 2026/01/01 00:00 [pmc-release] AID - neurosciences-31-1-18 [pii] AID - 10.17712/1658-3183.1002 [doi] PST - ppublish SO - Neurosciences (Riyadh). 2026 Jan;31(1):18-25. doi: 10.17712/1658-3183.1002. Epub 2026 Mar 27. PMID- 42238684 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260604 LR - 20260813 IS - 2055-2076 (Print) IS - 2055-2076 (Electronic) IS - 2055-2076 (Linking) VI - 12 DP - 2026 Jan-Dec TI - The association between digital health literacy and healthy lifestyle behaviors among youth: Systematic review of cross-sectional studies. PG - 20552076261456577 LID - 10.1177/20552076261456577 [doi] LID - 20552076261456577 AB - OBJECTIVE: To systematically identify and critically evaluate research evidence on the association between digital health literacy (DHL) and healthy lifestyle behaviors (HLB) among youth. METHODS: A systematic search was conducted of five English-language databases-Web of Science, Scopus, ProQuest, EBSCO, and PubMed-covering publications from January 2006 to October 2025. This search was supplemented by reference list screening, resulting in the inclusion of 33 studies in the final review. RESULTS: Overall, youth exhibit a relatively high level of DHL, and the eHealth Literacy Scale (eHEALS) is the most frequently employed instrument for its assessment. HLB associated with DHL primarily encompassed domains such as physical activity, sleep, diet and nutrition, as well as mental health and stress management. Higher levels of DHL among youth were associated with more favorable HLB, but the magnitude and consistency of these associations varied across behavioral domains. CONCLUSION: This study aims to examine variations in the role of DHL across different HLB domains, guided by the COM-B behavior change model, which emphasizes the interaction of capability, opportunity, and motivation. Further research is warranted to clarify the mechanisms linking DHL with specific HLB, particularly through high-quality longitudinal and intervention studies. In addition, DHL measurement instruments should be refined to ensure their validity and applicability within the rapidly evolving digital health environment. CI - (c) The Author(s) 2026. FAU - Xu, Ruilin AU - Xu R AUID- ORCID: 0009-0009-0141-2545 AD - College of Physical Education and Health, East China Normal University, Shanghai, China. RINGGOLD: 12655 FAU - Jiang, Jiajun AU - Jiang J AUID- ORCID: 0009-0006-5834-0712 AD - College of Physical Education and Health, East China Normal University, Shanghai, China. RINGGOLD: 12655 FAU - Yin, Zhihua AU - Yin Z AD - College of Physical Education and Health, East China Normal University, Shanghai, China. RINGGOLD: 12655 FAU - Zhong, Qiying AU - Zhong Q AD - College of Physical Education and Health, East China Normal University, Shanghai, China. RINGGOLD: 12655 FAU - Liu, Duoer AU - Liu D AD - College of Physical Education and Health, East China Normal University, Shanghai, China. RINGGOLD: 12655 FAU - Sun, Mingzhu AU - Sun M AD - College of Physical Education and Health, East China Normal University, Shanghai, China. RINGGOLD: 12655 FAU - Xiong, Mingliang AU - Xiong M AD - College of Physical Education and Health, East China Normal University, Shanghai, China. RINGGOLD: 12655 AD - College of Physical Education, Hunan First Normal University, Changsha, China. LA - eng PT - Journal Article PT - Review DEP - 20260531 PL - United States TA - Digit Health JT - Digital health JID - 101690863 PMC - PMC13226989 OTO - NOTNLM OT - digital health literacy OT - healthy lifestyle behaviors OT - systematic review OT - youth COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/06/04 06:33 MHDA- 2026/06/04 06:34 PMCR- 2026/05/31 CRDT- 2026/06/04 05:30 PHST- 2026/01/30 00:00 [received] PHST- 2026/04/22 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/04 06:34 [medline] PHST- 2026/06/04 06:33 [pubmed] PHST- 2026/06/04 05:30 [entrez] PHST- 2026/05/31 00:00 [pmc-release] AID - 10.1177_20552076261456577 [pii] AID - 10.1177/20552076261456577 [doi] PST - epublish SO - Digit Health. 2026 May 31;12:20552076261456577. doi: 10.1177/20552076261456577. eCollection 2026 Jan-Dec. PMID- 42238253 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260604 LR - 20260813 IS - 2472-1972 (Electronic) IS - 2472-1972 (Linking) VI - 10 IP - 6 DP - 2026 Jun TI - Real-world growth outcomes of vosoritide in children with achondroplasia: a single-center cohort study. PG - bvag072 LID - 10.1210/jendso/bvag072 [doi] LID - bvag072 AB - CONTEXT: Vosoritide, a C-type natriuretic peptide analogue, is the first approved therapy targeting the pathophysiology of achondroplasia. While clinical trials demonstrate efficacy, individuals with prior orthopedic surgeries are typically excluded, and real-world data remain limited. OBJECTIVE: To evaluate real-world growth outcomes of vosoritide therapy in children with achondroplasia, including those with prior surgical interventions. METHODS: This retrospective analysis included 25 children with achondroplasia (17 boys, age range 2.9-14.3 years) treated with vosoritide for a mean duration of 12.7 months at a multidisciplinary center. Z-scores were calculated using an AI-assisted growth assessment tool previously validated for children with achondroplasia. Delta z-scores for height, sitting height, arm span, and body mass index (BMI) were calculated from baseline to follow-up. Multiple linear regression analyses assessed predictors of response. RESULTS: Mean height z-scores improved from -0.62 +/- 1.09 to -0.24 +/- 1.20 (P < .001). Mean arm span z-score increased from -1.28 +/- 0.93 to -0.96 +/- 0.91 (P = .007). Sitting height z-scores showed a non-significant trend toward improvement; BMI z-scores remained stable. Mean Delta height and Delta arm span z-score gains were +0.38 +/- 0.45 and +0.32 +/- 0.48, respectively. A subgroup analysis of 8 patients with vs 17 without prior limb-lengthening surgery showed no significant differences. Regression analyses adjusted for sex, age, BMI z-scores, and surgical history were likely underpowered to detect meaningful predictors of response. There were no serious treatment-related adverse events. CONCLUSION: Vosoritide therapy enhanced linear and appendicular growth in a real-world cohort of children with achondroplasia, including post-surgical patients. These findings align with clinical trial data and support the therapy's applicability across diverse clinical profiles. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Endocrine Society. FAU - Regev, Ravit AU - Regev R AUID- ORCID: 0000-0002-0846-733X AD - Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel, affiliated to The Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Waksman, Yarden AU - Waksman Y AD - Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel, affiliated to The Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Cohen-Sela, Eyal AU - Cohen-Sela E AUID- ORCID: 0009-0008-0083-9443 AD - Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel, affiliated to The Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Brener, Avivit AU - Brener A AUID- ORCID: 0000-0002-2742-8264 AD - Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel, affiliated to The Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Dechovich, Nechama AU - Dechovich N AD - Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel, affiliated to The Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Gal, Maya AU - Gal M AD - Department of Occupational Therapy, The Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv 6997801, Israel. FAU - Borger, Ophir AU - Borger O AUID- ORCID: 0000-0001-6019-4159 AD - Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel, affiliated to The Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. AD - The Nutrition & Dietetics Unit, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel. FAU - Zeitlin, Leonid AU - Zeitlin L AD - Pediatric Orthopedic Department, Dana-Dwek Children's Hospital, Tel Aviv 6423906, Israel. FAU - Lebenthal, Yael AU - Lebenthal Y AUID- ORCID: 0000-0001-5963-0574 AD - Institute of Pediatric Endocrinology, Diabetes and Metabolism, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv 6423906, Israel, affiliated to The Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, Israel. LA - eng PT - Journal Article DEP - 20260328 PL - United States TA - J Endocr Soc JT - Journal of the Endocrine Society JID - 101697997 PMC - PMC13227001 OTO - NOTNLM OT - C-type natriuretic peptide (CNP) analog OT - achondroplasia OT - body proportions OT - growth-promoting therapy OT - skeletal dysplasia OT - vosoritide EDAT- 2026/06/04 06:32 MHDA- 2026/06/04 06:33 PMCR- 2026/03/28 CRDT- 2026/06/04 05:26 PHST- 2025/12/03 00:00 [received] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/06/04 06:33 [medline] PHST- 2026/06/04 06:32 [pubmed] PHST- 2026/06/04 05:26 [entrez] PHST- 2026/03/28 00:00 [pmc-release] AID - bvag072 [pii] AID - 10.1210/jendso/bvag072 [doi] PST - epublish SO - J Endocr Soc. 2026 Mar 28;10(6):bvag072. doi: 10.1210/jendso/bvag072. eCollection 2026 Jun. PMID- 42238241 OWN - NLM STAT- MEDLINE DCOM- 20260607 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Glycometabolic profiles and pregnancy outcomes across pathophysiological subtypes of gestational diabetes mellitus. PG - 1836589 LID - 10.3389/fendo.2026.1836589 [doi] LID - 1836589 AB - BACKGROUND: Gestational diabetes mellitus (GDM) exhibits profound pathophysiological heterogeneity, but current management fails to account for subtype-specific differences in clinical features and pregnancy prognoses. This study aimed to characterize the glycometabolic profiles and pregnancy outcomes of GDM subtypes defined by insulin resistance and beta-cell function, and provide a foundation for precision medicine in GDM. METHODS: In this 1:1 case-control study, 330 singleton women with GDM and 330 healthy singleton controls were enrolled. Using control-derived quartiles of HOMA-IR and HOMA-beta, GDM patients were classified into four subtypes: insulin resistance (GDM-IR), insulin secretory defect (GDM-IS), combined defect (GDM-M), and unclassified (GDM-N). Clinical characteristics, glycometabolic parameters, and pregnancy outcomes were compared across groups, and multivariate logistic regression identified independent risk factors for adverse pregnancy outcomes. RESULTS: Subtype distribution was: GDM-IR 36.4% (120/330), GDM-IS 22.7% (75/330), GDM-M 17.9% (59/330), GDM-N 23.0% (76/330). GDM-M showed the most severe glycometabolic derangements: highest first-trimester fasting glucose, all OGTT glucose values, HbA1c, insulin use rate (18.6%, 11/59), and poor glycemic control rate (22.0%, 13/59). It also had the highest rates of cesarean delivery (72.9%, 43/59), postpartum hemorrhage (8.5%, 5/59), preterm birth (18.6%, 11/59), macrosomia (17.0%, 10/59), and neonatal hypoglycemia (11.9%, 7/59) (all P < 0.05). Multivariate regression identified age (OR = 1.067, 95% CI: 1.028-1.108), pre-pregnancy BMI (OR = 1.073, 95% CI: 1.014-1.136), GDM-IS (OR = 2.013, 95% CI: 1.134-3.574), GDM-M (OR = 8.417, 95% CI: 2.661-26.627), and GDM-N (OR = 1.831, 95% CI: 1.076-3.115) as independent risk factors for adverse pregnancy outcomes, with GDM-M conferring the highest risk. CONCLUSIONS: GDM subtypes defined by insulin resistance and beta-cell function exhibit marked heterogeneity in glycometabolic profiles and pregnancy outcomes. The combined defect subtype (GDM-M) carries the highest risk of adverse maternal-neonatal events and may warrant the most intensive monitoring. These findings support pathophysiological subtyping for risk stratification, but causal inference is limited by the observational, single-center design; validation in multicenter, multi-ethnic prospective cohorts is required. CI - Copyright (c) 2026 Su, Luo, Huang, Huang and Wang. FAU - Su, Junyou AU - Su J AD - Department of Obstetrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. FAU - Luo, Jing AU - Luo J AD - Department of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China. FAU - Huang, Xiaoting AU - Huang X AD - Department of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China. FAU - Huang, Yan AU - Huang Y AD - Department of Obstetrics, The Second Affiliated Hospital of Guangxi Medical University, Nanning, China. FAU - Wang, Sumei AU - Wang S AD - Department of Obstetrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, China. LA - eng PT - Journal Article DEP - 20260519 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Blood Glucose) RN - 0 (Insulin) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Diabetes, Gestational/metabolism/physiopathology/blood/classification MH - *Pregnancy Outcome MH - Case-Control Studies MH - *Insulin Resistance/physiology MH - Adult MH - *Blood Glucose/metabolism/analysis MH - Risk Factors MH - Insulin/metabolism MH - Prognosis MH - Infant, Newborn PMC - PMC13225975 OTO - NOTNLM OT - gestational diabetes mellitus OT - glycometabolism OT - insulin resistance OT - pregnancy outcomes OT - subtypes COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/04 06:34 MHDA- 2026/06/07 18:43 PMCR- 2026/05/19 CRDT- 2026/06/04 05:26 PHST- 2026/03/23 00:00 [received] PHST- 2026/05/02 00:00 [revised] PHST- 2026/05/05 00:00 [accepted] PHST- 2026/06/07 18:43 [medline] PHST- 2026/06/04 06:34 [pubmed] PHST- 2026/06/04 05:26 [entrez] PHST- 2026/05/19 00:00 [pmc-release] AID - 10.3389/fendo.2026.1836589 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 May 19;17:1836589. doi: 10.3389/fendo.2026.1836589. eCollection 2026. PMID- 42237981 OWN - NLM STAT- MEDLINE DCOM- 20260609 LR - 20260813 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 15 DP - 2026 TI - Identifying healthy and sustainable high-impact eating behaviour in French children aged 6-15 years: a combined multidisciplinary and living lab participatory approach. PG - e38 LID - 10.1017/jns.2026.10105 [doi] LID - e38 AB - A growing standardisation of eating behaviours worldwide is observed, especially in children, notably characterised by the increasing consumption of both unsustainable animal- and plant-based ultra-processed foods (UPFs). The objective of this study was to identify five high-impact eating behaviours (HIBs) in a French child population (living in Clermont-Ferrand city and surroundings, n = 92, aged 6-15), that is, behaviours to change for the strongest positive impact on health and sustainability. For this, both multidisciplinary top-down and participatory bottom-up approaches has been carried out. First, from European and French dietary guidelines, desk research, European researchers' evaluation, and expert interviews and workshops the technical potential (for their impact on health and environment), plasticity and feasibility of 40 HIB were first quantified (top-down approach). Secondly, in the French living lab (LL), from photo-voice and focus groups with children, online surveys, meetings with families and children, interviews with stakeholders, and assessments of the behavioural change potential of the French LL children's target, five HIB were finally selected (bottom-up approach). Therefore, among the initial 342 European recommended eating behaviours, the selected HIBs for our specific population were: limiting the consumption of UPFs (notably those high in added salt, sugars and/or fats), eating 0-3 servings of meat/week, eating three servings of legumes/week, choosing primarily wholegrain than refined cereals, and choose water instead of sweetened beverages. These five HIBs constitutes a solid basis to perform next LL participatory actions, notably to test HIB feasibility/plasticity, and implement them in real life conditions through transversal actions with non-researcher. CI - (c) The Author(s) 2026. FAU - Fardet, Anthony AU - Fardet A AUID- ORCID: 0000-0003-4972-9217 AD - INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand & Clermont Auvergne Universite, Universite d'Auvergne, Unite de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France. ROR: https://ror.org/003vg9w96 FAU - Planchat-Hery, Claire AU - Planchat-Hery C AD - INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand & Clermont Auvergne Universite, Universite d'Auvergne, Unite de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France. ROR: https://ror.org/003vg9w96 FAU - Rock, Edmond AU - Rock E AD - INRA, UMR 1019, UNH, CRNH Auvergne, F-63000 Clermont-Ferrand & Clermont Auvergne Universite, Universite d'Auvergne, Unite de Nutrition Humaine, BP 10448, F-63000 Clermont-Ferrand, France. ROR: https://ror.org/003vg9w96 FAU - Bochan, Laureen AU - Bochan L AD - Department of Consumer Research, Communication, and Food Sociology, Justus-Liebig University, 35390 Giessen, Germany. LA - eng PT - Journal Article DEP - 20260526 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 SB - IM MH - Humans MH - Child MH - *Feeding Behavior MH - France MH - Female MH - Adolescent MH - Male MH - *Diet, Healthy MH - Nutrition Policy MH - *Diet MH - Food, Processed MH - Fast Foods MH - Focus Groups PMC - PMC13227139 OTO - NOTNLM OT - Children OT - Eating behaviours OT - Health OT - Living lab OT - Sustainability COIS- The authors declare none. EDAT- 2026/06/04 06:34 MHDA- 2026/06/09 06:36 PMCR- 2026/05/26 CRDT- 2026/06/04 05:24 PHST- 2025/05/13 00:00 [received] PHST- 2026/02/28 00:00 [revised] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/06/09 06:36 [medline] PHST- 2026/06/04 06:34 [pubmed] PHST- 2026/06/04 05:24 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - S2048679026101050 [pii] AID - 10.1017/jns.2026.10105 [doi] PST - epublish SO - J Nutr Sci. 2026 May 26;15:e38. doi: 10.1017/jns.2026.10105. eCollection 2026. PMID- 42237980 OWN - NLM STAT- MEDLINE DCOM- 20260609 LR - 20260813 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 15 DP - 2026 TI - Nutritional knowledge of team sport athletes. PG - e39 LID - 10.1017/jns.2026.10107 [doi] LID - e39 AB - Adequate nutritional knowledge (NK) is an essential aspect of team sport athletes (TSA) meeting their nutritional requirements, yet limited research has examined the NK of TSA using validated tools. This study aimed to assess the NK of male and female TSA using the validated Nutrition for Sport Knowledge Questionnaire (NSKQ) which was administered via the online platform REDCap. A total of 920 athletes (male n = 576 [62.6%], female n = 344 [37.4%]) from a range of sports including, Gaelic football n = 576 (62.6%), hurling & camogie n = 133 (14.5%), rugby n = 107 (11.6%) and soccer n = 104 (11.3%) completed the study. Participants were recruited from elite (county, country, province, professional) n = 343 (37.3%) and non-elite (club, university) n = 577 (62.7%) teams. The mean total score was 50.4 +/- 12.78%, considered 'average' using accepted cut-offs. Across sports, rugby players' total score was significantly higher when compared to Gaelic field sport athletes (p =.002). Scores in all NSKQ sub-sections fell within the 'average' or 'poor' category. NK was classified as 'poor' in the micronutrients (42.77 +/- 19.89%), sports nutrition (46.93 +/- 17.55%) and supplementation (35.42 +/- 18.86%) sub-sections, with 'poor' scoring in these sub-sections observed across all sports. In this study, NK was sub-optimal in 89.8% (n = 826) of participants and although 74.9% of participants expressed a desire for access to nutritional resources, the majority (64.3%) reported having no such access, as indicated by participant responses from the demographic section of NSKQ. These findings suggest TSA may benefit from tailored nutrition education interventions to enhance NK, potentially improving dietary intake and subsequently health and performance outcomes. CI - (c) The Author(s) 2026. FAU - McDonald, Chris V AU - McDonald CV AD - Nutrition Innovation Centre for Food & Health (NICHE), Ulster University, Coleraine, UK. ROR: https://ror.org/03hab3x36 FAU - McSorley, Emeir M AU - McSorley EM AUID- ORCID: 0000-0003-1861-3991 AD - Nutrition Innovation Centre for Food & Health (NICHE), Ulster University, Coleraine, UK. ROR: https://ror.org/03hab3x36 FAU - McNeilly, Andrea M AU - McNeilly AM AD - School of Sport and Exercise Sciences, Ulster University, Belfast, UK. FAU - Magee, Pamela J AU - Magee PJ AUID- ORCID: 0000-0002-0479-3314 AD - Nutrition Innovation Centre for Food & Health (NICHE), Ulster University, Coleraine, UK. ROR: https://ror.org/03hab3x36 LA - eng PT - Journal Article DEP - 20260601 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 SB - IM MH - Humans MH - Male MH - Female MH - *Athletes MH - *Health Knowledge, Attitudes, Practice MH - Surveys and Questionnaires MH - Young Adult MH - Adult MH - Nutritional Requirements MH - Gaelic Football MH - Soccer MH - *Sports Nutritional Physiological Phenomena MH - *Team Sports MH - Adolescent PMC - PMC13227125 OTO - NOTNLM OT - GAA OT - Nutritional knowledge OT - Rugby OT - Soccer OT - Team sport athlete EDAT- 2026/06/04 06:33 MHDA- 2026/06/10 06:52 PMCR- 2026/06/01 CRDT- 2026/06/04 05:24 PHST- 2025/12/08 00:00 [received] PHST- 2026/03/26 00:00 [revised] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/06/10 06:52 [medline] PHST- 2026/06/04 06:33 [pubmed] PHST- 2026/06/04 05:24 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - S2048679026101074 [pii] AID - 10.1017/jns.2026.10107 [doi] PST - epublish SO - J Nutr Sci. 2026 Jun 1;15:e39. doi: 10.1017/jns.2026.10107. eCollection 2026. PMID- 42237963 OWN - NLM STAT- MEDLINE DCOM- 20260604 LR - 20260813 IS - 1658-3175 (Electronic) IS - 0379-5284 (Print) IS - 0379-5284 (Linking) VI - 47 IP - 4 DP - 2026 Apr TI - A Comprehensive Analysis of Overweight, Obesity, and Failure to Thrive in Pediatric Inpatients: Prevalence, Diagnostic Practices, and Management Approaches at a Tertiary Hospital in Riyadh, Saudi Arabia. PG - 663-672 LID - 10.15537/1658-3175.1063 [doi] AB - OBJECTIVE: This study aimed to assess the prevalence, diagnostic accuracy, and inpatient management of pediatric weight abnormalities at a tertiary children's hospital in Riyadh, Saudi Arabia, using a retrospective cohort design. METHODS: The study analyzed medical records of pediatric inpatients aged 2-14 years admitted to King Abdullah Specialized Children's Hospital (KASCH) in 2023. Data collected included anthropometrics, dietary history, physical activity, diagnostic workup, and treatment plans. Overweight and obesity were classified using BMI percentiles, while FTT was identified via weight-for-age and growth percentile criteria. Descriptive statistics were used to analyze diagnostic accuracy and factors influencing missed diagnoses. RESULTS: Of 7,771 admissions, 760 patients (9.6%) had weight abnormalities: 60.3% with FTT, 24.2% obese, and 15.5% overweight. FTT was more accurately diagnosed (38%) than obesity (28%) or overweight (13%). Documentation of dietary intake was detailed in only 9.6% of cases; physical activity and screen time were universally undocumented. Obese children more frequently underwent metabolic testing and were referred to endocrinology, while FTT patients often received high-calorie formulas and follow-up with dietitians. Logistic regression revealed age group and dietary history documentation were significantly associated with diagnostic accuracy (p < 0.05). CONCLUSION: The study highlights underdiagnosis of overweight and obesity, suboptimal documentation practices, and inconsistent inpatient management of pediatric weight disorders. Despite standard anthropometric measurements, weight abnormalities are often overlooked during acute hospital care. FTT receives comparatively more clinical attention, while overweight and obesity remain underrecognized. CI - Copyright: (c) Saudi Medical Journal. FAU - Al Alwan, Ibrahim A AU - Al Alwan IA AUID- ORCID: 0000-0002-8982-6348 AD - Department of Pediatrics, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. AD - King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. FAU - AlShammari, Elaf A AU - AlShammari EA AD - Department of Pediatrics, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. AD - King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. FAU - AlAbdulkarim, Ahmed A AU - AlAbdulkarim AA AD - Department of Pediatrics, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. AD - King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. FAU - Ajeebi, Abdulaziz A AU - Ajeebi AA AD - Department of Pediatrics, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. AD - King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. FAU - AlHazimi, Afnan A AU - AlHazimi AA AD - Department of Pediatrics, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. AD - King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. FAU - AlHamied, Nawaf A AU - AlHamied NA AD - Department of Pediatrics, Ministry of the National Guard - Health Affairs, Riyadh, Saudi Arabia. AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. AD - King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. FAU - AlAsmari, Deema Y AU - AlAsmari DY AD - College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. AD - King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260320 PL - Saudi Arabia TA - Saudi Med J JT - Saudi medical journal JID - 7909441 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Child MH - Child, Preschool MH - Prevalence MH - Tertiary Care Centers MH - Male MH - Female MH - Retrospective Studies MH - *Overweight/epidemiology/diagnosis/therapy MH - Adolescent MH - *Pediatric Obesity/epidemiology/diagnosis/therapy MH - Inpatients/statistics & numerical data MH - Obesity/epidemiology/diagnosis PMC - PMC13227405 OTO - NOTNLM OT - FTT OT - Obesity OT - Overweight EDAT- 2026/06/04 06:33 MHDA- 2026/06/05 00:35 PMCR- 2026/04/01 CRDT- 2026/06/04 05:23 PHST- 2025/05/29 00:00 [received] PHST- 2025/11/13 00:00 [accepted] PHST- 2026/06/05 00:35 [medline] PHST- 2026/06/04 06:33 [pubmed] PHST- 2026/06/04 05:23 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - saudimedj-47-4-663 [pii] AID - 10.15537/1658-3175.1063 [doi] PST - ppublish SO - Saudi Med J. 2026 Apr;47(4):663-672. doi: 10.15537/1658-3175.1063. Epub 2026 Mar 20. PMID- 42237838 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260813 IS - 0971-5916 (Print) IS - 0971-5916 (Linking) VI - 163 IP - 5 DP - 2026 May TI - Untangling weight from height: A generalised body mass index (gBMI) approach to evaluating child and adolescent nutritional status in India. PG - 655-663 LID - 10.25259/IJMR_2555_2025 [pii] AB - Background and objectives Weight-for-height (WHZ) and body mass index (BMI)-for-age (BAZ) are commonly used to assess child overnutrition but have limitations: they conflate skeletal growth with body weight, correlate with height, and inadequately distinguish fat from lean mass, particularly during puberty. This study proposes an India-specific generalised body mass index (gBMI), an age- and sex-specific power-type index adapted from Benn's concept, to better capture adiposity. Methods Exponent parameters for gBMI were estimated using healthy-child data, selected by WHO selection criteria, from the National Family Health Survey (NFHS-3,4,5) and the Comprehensive National Nutrition Survey (CNNS), comprising 12,466 children under 5 years and 6,487 aged 5-19 years. Polynomial regression to model age- and sex-specific variation in the weight-height relationship was used to estimate the exponents of height, and growth curves were generated using generalised additive models for location, scale, and shape (GAMLSS) with location scale and shape (LMS) methods. Validation employed independent data from 457 urban schoolchildren aged 5-16 years in Bengaluru, including fat and lean mass measured by dual-energy X-ray absorptiometry (DXA). Results The exponent varied with age (1.3 in infancy, approximately 2.9 in pubertal boys, 2.7 in girls, stabilising at approximately 2 in late adolescence). Unlike BMI, gBMI residuals showed near-zero correlation with height. gBMI-for-age Z-scores (gBAZ) showed lower wasting in children under 5 years (10.7% vs. 19.2% using WHZ) and higher adolescent overnutrition (8.7% vs. <1% using BAZ). Validation showed stronger association of gBAZ with body fat (r=0.70) than BAZ (r=0.65). Interpretation and conclusions The gBMI provides an adaptable, height-independent, and adiposity-sensitive index for assessing malnutrition and obesity in children and adolescents. Its use could refine nutritional surveillance and interventions, with potential wider applicability with longitudinal evaluations. FAU - Majumder, Rajesh AU - Majumder R AD - Department of Biostatistics, Manipal Academy of Higher Education, Manipal, Karnataka, India. AD - Division of Biostatistics and Epidemiology, St John's Research Institute, Bengaluru, Karnataka, India. FAU - Kurpad, Anura Viswanath AU - Kurpad AV AD - Department of Physiology, St John's Medical College, Bengaluru, Karnataka, India. FAU - Sachdev, Harshpal Singh AU - Sachdev HS AD - Department of Pediatrics, Sitaram Bhartia Institute of Science and Research, New Delhi, India. FAU - Kuriyan, Rebecca AU - Kuriyan R AD - Division of Nutrition, St John's Research Institute, Bengaluru, Karnataka, India. AD - Department of Physiology, St John's Medical College, Bengaluru, Karnataka, India. FAU - Thomas, Tinku AU - Thomas T AD - Department of Biostatistics, St John's Medical College, Bengaluru, Karnataka, India. FAU - Ghosh, Santu AU - Ghosh S AD - Department of Biostatistics, St John's Medical College, Bengaluru, Karnataka, India. LA - eng PT - Journal Article PL - United States TA - Indian J Med Res JT - The Indian journal of medical research JID - 0374701 SB - IM MH - Humans MH - Body Mass Index MH - Child MH - India/epidemiology MH - Male MH - Adolescent MH - *Nutritional Status/physiology MH - Child, Preschool MH - Female MH - *Body Weight/physiology MH - *Body Height/physiology MH - Adiposity/physiology MH - Nutrition Surveys MH - Young Adult MH - *Obesity/epidemiology/physiopathology MH - Absorptiometry, Photon PMC - PMC13235558 OTO - NOTNLM OT - Anthropometry OT - BMI OT - Obesity OT - Z-score OT - gBMI COIS- None. EDAT- 2026/06/04 06:34 MHDA- 2026/06/11 06:36 PMCR- 2026/05/01 CRDT- 2026/06/04 04:19 PHST- 2025/09/17 00:00 [received] PHST- 2025/12/09 00:00 [accepted] PHST- 2026/06/11 06:36 [medline] PHST- 2026/06/04 06:34 [pubmed] PHST- 2026/06/04 04:19 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 10.25259/IJMR_2555_2025 [pii] AID - 10.25259/IJMR_2555_2025 [doi] PST - ppublish SO - Indian J Med Res. 2026 May;163(5):655-663. doi: 10.25259/IJMR_2555_2025. PMID- 42237280 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260915 IS - 1475-2840 (Electronic) IS - 1475-2840 (Linking) VI - 25 IP - 1 DP - 2026 Jun 3 TI - Adolescent obesity and risk of serious chronic morbidity and mortality in young adulthood: a systematic review of cohorts from national registries. LID - 10.1186/s12933-026-03221-0 [doi] LID - 213 AB - BACKGROUND: The rising prevalence of adolescent obesity necessitates a precise understanding of its corresponding risks for severe chronic morbidity and premature mortality during young adulthood and midlife. METHODS: We conducted a systematic review of nationwide longitudinal cohort studies, using validated national registries, aimed at assessing the short- and long-term risk of morbidity and mortality associated with adolescent overweight and obesity. RESULTS: We included 38 studies in this systematic review. Adolescent overweight and obesity were associated with severe morbidity and disease related mortality, from young adulthood. Within < 4 years of follow-up and before the age of 25 years, severe adolescent obesity was associated with increased risk of serious morbidity (hazard ratio (HR) = 5.1 among men and HR = 7.3 among women), type 2 diabetes (HR = 27.0 among men, and HR = 45.3 among women), and obesity was associated with type 1 diabetes (HR = 2.0). Before the age of 30 years, adolescent severe obesity was associated with chronic kidney disease (CKD), obesity was associated with colorectal cancer (CRC) and with cardiovascular disease (CVD) mortality. Before the age of 40 years adolescent overweight and obesity were associated with ischemic stroke. Last, before the age of 50 years, adolescent severe obesity was associated with all-cause mortality, obesity was associated with diabetes mortality, and cancer. CONCLUSIONS: Adolescent obesity is strongly associated with an elevated hazard for severe disease morbidity and mortality beginning in young adulthood, with associations progressing with obesity severity and time. The findings of this study demonstrate the need for public health mitigation and preventive strategies, which may yield substantial short, and long-term health benefits in this population. CI - (c) 2026. The Author(s). FAU - Fliss Isakov, Naomi AU - Fliss Isakov N AD - Nutrition Division, Public Health Directorate, Ministry of Health, Jerusalem, Israel. naomi.fliss@moh.gov.il. AD - Department of Health Promotion, School of Public Health, Gray Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. naomi.fliss@moh.gov.il. AD - The Gertner Institute for Epidemiology & Health Policy Research, Sheba Medical Center, Ramat Gan, Israel. naomi.fliss@moh.gov.il. FAU - Balmakov, Yulia AU - Balmakov Y AD - Department of Military Medicine and "Tzameret", Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. AD - Israel Defense Forces Medical Corps, Ramat Gan, Israel. FAU - Grinshpan, Laura Sol AU - Grinshpan LS AD - Nutrition Division, Public Health Directorate, Ministry of Health, Jerusalem, Israel. AD - School of Public Health, Haifa University, Haifa, Israel. FAU - Tsur, Eyal AU - Tsur E AD - Department of Military Medicine and "Tzameret", Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. AD - Israel Defense Forces Medical Corps, Ramat Gan, Israel. FAU - Issler, Nitzan AU - Issler N AD - Gray Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Blaychfeld Magnazi, Moran AU - Blaychfeld Magnazi M AD - Nutrition Division, Public Health Directorate, Ministry of Health, Jerusalem, Israel. AD - Faculty of Health Sciences, Department of Nutrition Sciences, Ariel University, Ariel, Israel. FAU - Aviad Beer, Zivan AU - Aviad Beer Z AD - Department of Military Medicine and "Tzameret", Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. AD - Israel Defense Forces Medical Corps, Ramat Gan, Israel. FAU - Pinhas-Hamiel, Orit AU - Pinhas-Hamiel O AD - Gray Faculty of Medicine and Health Sciences, Tel Aviv University, Tel Aviv, Israel. AD - Pediatric Endocrine and Diabetes Division, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel-Hashomer, Ramat Gan, Israel. AD - Juvenile Diabetes Center, Maccabi Health Care Services, Ra'anana, Israel. FAU - Twig, Gilad AU - Twig G AD - The Gertner Institute for Epidemiology & Health Policy Research, Sheba Medical Center, Ramat Gan, Israel. AD - Department of Preventive Medicine and Epidemiology, School of Public Health, Gray Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel. AD - The Division of Endocrinology Diabetes and Metabolism, Sheba Medical Center, Ramat Gan, Israel. AD - Incumbent of the Hella Gertner Chair for Research in Hypertension, Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Shina, Avi AU - Shina A AD - Department of Military Medicine and "Tzameret", Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. AD - Israel Defense Forces Medical Corps, Ramat Gan, Israel. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260603 PL - England TA - Cardiovasc Diabetol JT - Cardiovascular diabetology JID - 101147637 SB - IM MH - Humans MH - Risk Factors MH - Female MH - Adolescent MH - Male MH - Registries MH - Young Adult MH - Risk Assessment MH - Time Factors MH - Age Factors MH - Adult MH - *Pediatric Obesity/mortality/diagnosis/epidemiology MH - Prevalence MH - Diabetes Mellitus, Type 2/mortality/diagnosis/epidemiology MH - Chronic Disease MH - Prognosis MH - Cause of Death MH - Age of Onset PMC - PMC13419026 OTO - NOTNLM OT - Adolescent obesity OT - Life course epidemiology OT - Nationwide cohort studies COIS- Declarations. Ethics approval: The study protocol was approved by the ethics committee of the Israeli Ministry of health Consent for publication: not applicable EDAT- 2026/06/04 06:35 MHDA- 2026/07/30 06:41 PMCR- 2026/06/03 CRDT- 2026/06/04 00:37 PHST- 2026/02/26 00:00 [received] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/07/30 06:41 [medline] PHST- 2026/06/04 06:35 [pubmed] PHST- 2026/06/04 00:37 [entrez] PHST- 2026/06/03 00:00 [pmc-release] AID - 10.1186/s12933-026-03221-0 [pii] AID - 3221 [pii] AID - 10.1186/s12933-026-03221-0 [doi] PST - epublish SO - Cardiovasc Diabetol. 2026 Jun 3;25(1):213. doi: 10.1186/s12933-026-03221-0. PMID- 42236840 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260815 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 3 TI - The normal distance from soft tissue nasion to the arbitrary axis-orbital plane is similar in pediatric, adolescent, and young adult samples. LID - 10.1038/s41598-026-56184-3 [doi] LID - 25260 AB - Anatomical facebows establish the arbitrary axis-orbital plane by assessing both the hinge axis points and landmark orbitale. The estimated point orbitale results from the facebow's nasion relator height of 25.4 mm. This height was investigated in adults but it is unclear if their anthropometric dimensions adequately translate to children and adolescents. The present cross-sectional study aimed to evaluate the validity of this height retrospectively for the ages 6 to19.9 years. We used lateral cephalometric radiographs of 420 individuals (210 males, 210 females,) and divided the sample into 7 age groups. A single investigator measured the perpendicular distance of soft tissue nasion to a line connecting the averaged arbitrary hinge axis point and the averaged point orbitale. Data were analyzed using an ordinary least squares linear regression model (p < 0.05). The perpendicular distances ranged from 11 to 33.5 mm (mean 22.8, standard deviation 3.5). There were no significant differences of the distance between age groups, or sex within age groups, or sex between age groups. The use of a fixed 25.4 mm nasion relator height in children and adolescents was not associated with more instrumental error in assessing point orbitale than in the adult age group. The present study's data did not preclude application of this nasion relator height from age 6 years onward. CI - (c) 2026. The Author(s). FAU - Celar, Ales AU - Celar A AD - Medical University of Vienna, University Clinic of Dentistry, Sensengasse 2a, 1090, Wien, Austria. ales.celar@meduniwien.ac.at. FAU - Lettner, Stefan AU - Lettner S AD - Medical University of Vienna, University Clinic of Dentistry, Sensengasse 2a, 1090, Wien, Austria. FAU - Jonke, Erwin AU - Jonke E AD - Medical University of Vienna, University Clinic of Dentistry, Sensengasse 2a, 1090, Wien, Austria. LA - eng PT - Journal Article DEP - 20260603 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Child MH - Adolescent MH - Female MH - *Orbit/anatomy & histology/diagnostic imaging MH - Male MH - *Cephalometry/methods MH - Young Adult MH - Cross-Sectional Studies MH - Adult MH - Retrospective Studies PMC - PMC13470210 OTO - NOTNLM OT - Anatomical facebow OT - Arbitrary facebow OT - Axis-orbital plane OT - Nasion relator height OT - Orbitale COIS- Declarations. Competing interests: Regarding the Competing Interests Statement, all authors declare that there are none and that no financial and non-financial conflicts of interest exist with respect to the authorship and/or publication of this article. EDAT- 2026/06/04 00:37 MHDA- 2026/08/13 05:35 PMCR- 2026/06/03 CRDT- 2026/06/03 23:34 PHST- 2026/03/06 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/08/13 05:35 [medline] PHST- 2026/06/04 00:37 [pubmed] PHST- 2026/06/03 23:34 [entrez] PHST- 2026/06/03 00:00 [pmc-release] AID - 10.1038/s41598-026-56184-3 [pii] AID - 56184 [pii] AID - 10.1038/s41598-026-56184-3 [doi] PST - epublish SO - Sci Rep. 2026 Jun 3;16(1):25260. doi: 10.1038/s41598-026-56184-3. PMID- 42234621 OWN - NLM STAT- MEDLINE DCOM- 20260702 LR - 20260702 IS - 1531-698X (Electronic) IS - 1040-8703 (Linking) VI - 38 IP - 4 DP - 2026 Aug 1 TI - Assessment and treatment of adolescent hair loss. PG - 348-357 LID - 10.1097/MOP.0000000000001582 [doi] AB - PURPOSE OF REVIEW: Hair loss in adolescents carries significant psychosocial impact, and it is often underrecognized and managed without adolescent-specific approaches. This review describes recent advances in diagnostics, pathophysiology, and therapies to improve diagnosis and management of adolescent alopecia. RECENT FINDINGS: Trichoscopy and ultraviolet-enhanced follicular dermoscopy improve diagnostic accuracy and reduce invasive testing. Androgenetic alopecia is linked to obesity and genetic predisposition; topical minoxidil remains first-line with low-dose oral minoxidil use supported in some cases. Alopecia areata severity frameworks now include chronicity, relapse, nonscalp involvement, refractoriness, and psychosocial burden. Systemic JAK inhibitors have emerged as treatment options for adolescents with sustained regrowth and patient-reported improvements. Psychogenic hair loss is often comorbid with anxiety, obsessive-compulsive disorder, or attention-deficit/hyperactivity disorder. SUMMARY: Early, etiology-driven assessment and multidisciplinary care are critical for adolescent hair loss. Adolescent-specific data support more individualized systemic treatments for some types of hair loss, while gaps remain in preventive strategies and long-term outcomes, highlighting priorities for future research. CI - Copyright (c) 2026 Wolters Kluwer Health, Inc. All rights reserved. FAU - Conza, Adrienne AU - Conza A AD - UMass Chan Medical School, Worcester. FAU - Alzahrani, Nujood AU - Alzahrani N AD - Dermatology Section, Division of Immunology, Boston Children's Hospital. AD - Harvard Medical School, Boston, Massachusetts, USA. FAU - Damji, Yasin AU - Damji Y AD - Dermatology Section, Division of Immunology, Boston Children's Hospital. AD - Harvard Medical School, Boston, Massachusetts, USA. LA - eng PT - Journal Article PT - Review DEP - 20260605 PL - United States TA - Curr Opin Pediatr JT - Current opinion in pediatrics JID - 9000850 RN - 5965120SH1 (Minoxidil) SB - IM MH - Humans MH - Adolescent MH - *Alopecia/diagnosis/therapy/etiology/psychology MH - Minoxidil/therapeutic use MH - Dermoscopy/methods OTO - NOTNLM OT - adolescent OT - alopecia OT - hair loss OT - pediatrics EDAT- 2026/06/03 18:38 MHDA- 2026/07/02 06:40 CRDT- 2026/06/03 13:32 PHST- 2026/07/02 06:40 [medline] PHST- 2026/06/03 18:38 [pubmed] PHST- 2026/06/03 13:32 [entrez] AID - 00008480-202608000-00005 [pii] AID - 10.1097/MOP.0000000000001582 [doi] PST - ppublish SO - Curr Opin Pediatr. 2026 Aug 1;38(4):348-357. doi: 10.1097/MOP.0000000000001582. Epub 2026 Jun 5. PMID- 42233991 OWN - NLM STAT- MEDLINE DCOM- 20260924 LR - 20261008 IS - 1432-198X (Electronic) IS - 0931-041X (Linking) VI - 41 IP - 11 DP - 2026 Nov TI - Weight changes and variability in the first week of life: associations with mortality in extremely preterm newborns. PG - 4005-4015 LID - 10.1007/s00467-026-07371-x [doi] AB - BACKGROUND: In extremely preterm newborns (ELGANs, < 28 weeks' gestational age [GA]), early weight trajectories reflect fluid balance, yet thresholds for early risk stratification are lacking. We aimed to evaluate whether percentage weight change (DeltaW%) from birth weight (BW) and week-1 weight variability were independently associated with death by postnatal day 7 and to identify clinically relevant thresholds. METHODS: We performed a retrospective single-center secondary analysis of the Golden Week Program (University of Alabama at Birmingham NICU, 2014-2021). Newborns < 28 weeks' GA with BW >/= 400 g and receiving active treatment were included; exclusion criteria were death 5% of BW are at increased risk of early mortality. These weight-derived metrics may support early risk stratification but require prospective validation. CI - (c) 2026. The Author(s), under exclusive licence to International Pediatric Nephrology Association. FAU - Vigezzi, Serena AU - Vigezzi S AUID- ORCID: 0009-0005-8359-1145 AD - Pediatric Nephrology Unit, Department of Women's and Children's Health, Padua University Hospital, Via Giustiniani 2, Padua, 35128, Italy. serenavigezzi@gmail.com. FAU - Resnick, Elad AU - Resnick E AUID- ORCID: 0000-0003-0270-678X AD - Department of Pediatrics, University of Alabama at Birmingham, 1700 6Th Avenue South, WIC, Suite 9380, Birmingham, AL, 35233, USA. FAU - Vidal, Enrico AU - Vidal E AUID- ORCID: 0000-0003-3963-0803 AD - Pediatric Nephrology Unit, Department of Women's and Children's Health, Padua University Hospital, Via Giustiniani 2, Padua, 35128, Italy. FAU - Ambalavanan, Namasivayam AU - Ambalavanan N AUID- ORCID: 0000-0003-0731-9092 AD - Department of Pediatrics, University of Alabama at Birmingham, 1700 6Th Avenue South, WIC, Suite 9380, Birmingham, AL, 35233, USA. FAU - Travers, Colm P AU - Travers CP AUID- ORCID: 0000-0002-3218-1024 AD - Department of Pediatrics, University of Alabama at Birmingham, 1700 6Th Avenue South, WIC, Suite 9380, Birmingham, AL, 35233, USA. FAU - Askenazi, David J AU - Askenazi DJ AUID- ORCID: 0000-0002-6840-9887 AD - Department of Pediatrics, University of Alabama at Birmingham, 1700 6Th Avenue South, WIC, Suite 9380, Birmingham, AL, 35233, USA. LA - eng GR - NHLBI K23HL157618/NH/NIH HHS/United States GR - NHLBI K23HL157618/NH/NIH HHS/United States PT - Journal Article DEP - 20260603 PL - Germany TA - Pediatr Nephrol JT - Pediatric nephrology (Berlin, Germany) JID - 8708728 SB - IM MH - Humans MH - Infant, Newborn MH - *Infant, Extremely Premature/physiology MH - Retrospective Studies MH - Female MH - Male MH - Gestational Age MH - Birth Weight MH - *Infant Mortality MH - Risk Assessment/methods MH - *Weight Gain MH - Risk Factors MH - Alabama/epidemiology MH - *Body-Weight Trajectory OTO - NOTNLM OT - ELGANs OT - Fluid overload OT - Mortality OT - Neonate OT - Weight loss COIS- Declarations. Conflict of interest: Namasivayam Ambalavanan reports financial support provided by National Institutes of Health. David J. Askenazi reports research funding from Vantive; consulting/advisory roles with Nuwellis Inc. and SeaStar Medical; equity/stock ownership in Zorro-Flow Inc.; is an inventor on an issued patent for a female non-invasive urine collection device; and is an inventor on a pending patent for "Fluid Aviator," a device to help monitor, prescribe, and project cumulative fluid balance. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/03 12:40 MHDA- 2026/09/25 05:31 CRDT- 2026/06/03 11:03 PHST- 2026/02/17 00:00 [received] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/04/17 00:00 [revised] PHST- 2026/09/25 05:31 [medline] PHST- 2026/06/03 12:40 [pubmed] PHST- 2026/06/03 11:03 [entrez] AID - 10.1007/s00467-026-07371-x [pii] AID - 10.1007/s00467-026-07371-x [doi] PST - ppublish SO - Pediatr Nephrol. 2026 Nov;41(11):4005-4015. doi: 10.1007/s00467-026-07371-x. Epub 2026 Jun 3. PMID- 42233406 OWN - NLM STAT- MEDLINE DCOM- 20260605 LR - 20260609 IS - 1464-5033 (Electronic) IS - 0301-4460 (Linking) VI - 53 IP - 1 DP - 2026 Dec TI - Body composition phenotyping of obesity in children aged 6-18 years: multi-strategy clustering and interpretable machine learning. PG - 2661592 LID - 10.1080/03014460.2026.2661592 [doi] AB - BACKGROUND: Body composition heterogeneity in childhood obesity is not fully captured by BMI, motivating operational phenotyping using non-invasive measures. AIM: To identify body composition-based phenotypes of obesity in children aged 6-18 years using complementary clustering approaches and characterise their discriminative structure through interpretable machine learning. SUBJECTS AND METHODS: We enrolled 78 obese children (6-18 years) from a single-centre outpatient clinic in a cross-sectional design. Thirteen BIA-derived indices were Z-standardised and analysed using parallel unsupervised strategies (PCA-K-means, HCPC, UMAP-DBSCAN). Cluster quality, stability, and agreement were evaluated by mean silhouette, Jaccard bootstrap (100 resamples), and adjusted Rand index (ARI). Separability was assessed with a random forest classifier using five-fold cross-validation (out-of-fold accuracy; macro/micro AUC), with SHAP for interpretability. RESULTS: Four phenotypes were consistently supported: low-fat/high-muscle, balanced, high-fat/low-muscle, and mixed high-fat/high-muscle. Cross-validated performance was 85.9% accuracy, macro AUC 0.953, and micro AUC 0.965. Structural metrics were silhouette 0.41 and ARI 0.94, with cluster-wise Jaccard 0.789/0.812/0.835/0.858 (range 0.78-0.86). SHAP prioritised fat mass and BMI; BIA-derived basal metabolic indices contributed as device-estimated outputs, while lean mass and skeletal muscle mass showed opposing contributions. CONCLUSIONS: This exploratory, single-centre framework is hypothesis-generating and requires external validation with outcome-linked markers and imaging before any clinical applicability is considered. FAU - Wang, Yuhang AU - Wang Y AUID- ORCID: 0009-0000-0454-3449 AD - Yiwu Maternity and Children Hospital, Yiwu, Zhejiang, China. AD - Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China. FAU - Shi, Shuang AU - Shi S AD - Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China. AD - Zhumadian Central Hospital, Zhumadian, Henan, China. FAU - Cai, Jin AU - Cai J AD - Department of Pediatrics, Affiliated Hospital of Nantong University, Nantong, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260603 PL - England TA - Ann Hum Biol JT - Annals of human biology JID - 0404024 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Body Composition/physiology MH - Cluster Analysis MH - *Clustering Algorithms MH - Cross-Sectional Studies MH - *Machine Learning MH - *Pediatric Obesity/diagnosis/physiopathology MH - *Phenotype OTO - NOTNLM OT - Childhood obesity OT - SHAP OT - bioelectrical impedance analysis OT - body composition OT - random forest OT - unsupervised clustering EDAT- 2026/06/03 12:38 MHDA- 2026/06/06 00:35 CRDT- 2026/06/03 07:13 PHST- 2026/06/06 00:35 [medline] PHST- 2026/06/03 12:38 [pubmed] PHST- 2026/06/03 07:13 [entrez] AID - 10.1080/03014460.2026.2661592 [doi] PST - ppublish SO - Ann Hum Biol. 2026 Dec;53(1):2661592. doi: 10.1080/03014460.2026.2661592. Epub 2026 Jun 3. PMID- 42233337 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260730 IS - 2153-2176 (Electronic) IS - 2153-2168 (Linking) VI - 22 IP - 6 DP - 2026 Sep TI - Cost-Effectiveness of Access to Obesity Care and Treatments for Adolescents. PG - 379-388 LID - 10.1177/21532176261454487 [doi] AB - BACKGROUND: Inadequate care access may exacerbate the childhood obesity epidemic. Obesity treatments are recommended for adolescents, but the health-economic impacts of unequal treatment access are unclear. This study aims to evaluate the cost-effectiveness of improving access levels to adolescent obesity care and treatment. METHODS: In this economic evaluation, we used a decision-analytic model to simulate a synthetic cohort of 1000 US adolescents from ages 12 to 26 on an annual basis. Modeled treatment strategies included phentermine-topiramate, semaglutide, bariatric surgery, and lifestyle modification (usual care). Primary analysis modeled perfect care access for reproducibility with prior studies. Secondary analyses modeled imperfect access to primary care visits, specialty visits, and treatment initiation among distinct groups by insurance coverage or race and ethnicity. Uncertainty analyses tested model parameter estimates. Outcomes were costs, health effects [averted obesity cases, quality-adjusted life years (QALYs)], and incremental cost-effectiveness ratios (ICERs) from health care sector and limited societal perspectives, including caregiver time. RESULTS: Phentermine-topiramate (vs. lifestyle) yielded an ICER of 2025 US$112,141/QALY, and semaglutide (vs. phentermine-topiramate) yielded $166,513/QALY under perfect access. Under imperfect access, cost-effectiveness and health gains were reduced. Cost-effectiveness was reduced by 11%, and averted obesity cases decreased from 57% to 3% for semaglutide. Health gains were lowest in Medicaid-insured, Black, or Hispanic youth. ICERs were sensitive to medication characteristics (costs, efficacy, discontinuation) and health utilities. CONCLUSIONS: In this economic evaluation, phentermine-topiramate and semaglutide were cost-effective under $200,000/QALY, using 2025 pricing. Care access disparities limit health-economic gains for adolescents. Improving care access is critical to addressing the childhood obesity epidemic. FAU - Doan, Tran T AU - Doan TT AUID- ORCID: 0000-0001-8862-5707 AD - Department of Health Systems, Management, and Policy, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Mueller, Heeseung J AU - Mueller HJ AD - Health Outcomes Division, The University of Texas at Austin College of Pharmacy, Austin, Texas, USA. FAU - Avancena, Anton L V AU - Avancena ALV AD - Health Outcomes Division, The University of Texas at Austin College of Pharmacy, Austin, Texas, USA. AD - Department of Internal Medicine, The University of Texas at Austin Dell Medical School, Austin, Texas, USA. FAU - Peyyety, Vaishnavi AU - Peyyety V AD - Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania, USA. FAU - Bensignor, Megan O AU - Bensignor MO AD - Department of Pediatrics, Center for Pediatric Obesity Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA. FAU - Vajravelu, Mary Ellen AU - Vajravelu ME AD - Division of Pediatric Endocrinology, Center for Pediatric Research in Obesity and Metabolism, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. LA - eng PT - Journal Article DEP - 20260603 PL - United States TA - Child Obes JT - Childhood obesity (Print) JID - 101542497 RN - 53AXN4NNHX (Semaglutide) RN - 0 (Anti-Obesity Agents) RN - C045TQL4WP (Phentermine) RN - 0H73WJJ391 (Topiramate) RN - 62340-29-8 (Glucagon-Like Peptides) SB - IM MH - Humans MH - *Cost-Effectiveness Analysis MH - *Cost-Benefit Analysis MH - Adolescent MH - Semaglutide MH - *Health Services Accessibility/economics/statistics & numerical data MH - *Pediatric Obesity/therapy/economics MH - Female MH - Anti-Obesity Agents/therapeutic use/economics MH - United States MH - Child MH - Male MH - Phentermine/economics/therapeutic use MH - Topiramate/therapeutic use/economics MH - Glucagon-Like Peptides/therapeutic use/economics MH - Young Adult MH - Quality-Adjusted Life Years MH - Bariatric Surgery/economics OTO - NOTNLM OT - access to care OT - adolescent obesity OT - cost-effectiveness OT - economic evaluation OT - semaglutide OT - treatment COIS- Author Disclosure StatementThe authors declared no conflicts of interest. EDAT- 2026/06/03 12:38 MHDA- 2026/07/30 06:41 CRDT- 2026/06/03 06:23 PHST- 2026/07/30 06:41 [medline] PHST- 2026/06/03 12:38 [pubmed] PHST- 2026/06/03 06:23 [entrez] AID - 10.1177/21532176261454487 [doi] PST - ppublish SO - Child Obes. 2026 Sep;22(6):379-388. doi: 10.1177/21532176261454487. Epub 2026 Jun 3. PMID- 42233315 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260813 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Jun 3 TI - Adapting and validating the FOODLIT-Tool in Turkish: a psychometric study on food literacy for sustainability. PG - e128 LID - 10.1017/S1368980026102821 [doi] LID - e128 AB - OBJECTIVE: This study aimed to adapt and validate the FOODLIT-Tool in Turkish to assess sustainable food literacy among Turkish adults. The adaptation addresses a lack of psychometrically validated instruments for measuring food literacy and sustainability-oriented eating behaviours in Turkey. DESIGN: A psychometric evaluation was conducted, including forward-translation, back-translation and cultural adaptation steps, followed by expert review for content validation. Construct validity was assessed using confirmatory factor analysis (CFA), and internal consistency was evaluated to ensure reliability. SETTING: Data collection was conducted online via Google Forms between July and August 2024. PARTICIPANTS: A total of 482 participants aged 18 to 65 years residing in Turkey voluntarily completed the Turkish version of the FOODLIT-Tool, along with a general information form and the Sustainable and Healthy Eating Behavior Scale. RESULTS: CFA results demonstrated an acceptable model fit (chi(2)/df = 3.67, CFI = 0.91, RMSEA = 0.07). Cronbach's alpha values ranged from 0.60 to 0.91 across the sub-dimensions, indicating adequate to excellent internal consistency. Significant positive correlations were found between FOODLIT subscales and sustainable eating behaviours. Women scored significantly higher in culinary competence, production quality and environmental awareness. CONCLUSIONS: The adapted Turkish version of the FOODLIT-Tool demonstrates satisfactory validity and reliability for evaluating food literacy and sustainable dietary practices among Turkish adults. The scale serves as a useful assessment tool for future research and intervention studies focusing on sustainable nutrition. Further validation using representative samples and longitudinal designs is warranted before its application in public health or policy-making contexts. FAU - Atar, Aslihan AU - Atar A AUID- ORCID: 0000-0003-2941-4269 AD - Nutrition and Dietetics, Istanbul Beykent Universitesi, Turkiye. AD - Istanbul Medipol University - Kavacik Campus, Turkiye. FAU - Sahin Anilgan, Irem Nur AU - Sahin Anilgan IN AUID- ORCID: 0000-0002-5446-9467 AD - https://ror.org/054xkpr46Gazi University, Turkiye. AD - https://ror.org/03dcvf827Istanbul Beykent University - Beylikduzu Campus, Turkiye. FAU - Pulat Demir, Halime AU - Pulat Demir H AD - Nutrition and Dietetics, Istanbul Beykent Universitesi, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20260603 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Turkey MH - *Psychometrics MH - Female MH - Reproducibility of Results MH - Adult MH - Middle Aged MH - *Health Literacy MH - Adolescent MH - Male MH - *Diet, Healthy/psychology MH - Young Adult MH - Surveys and Questionnaires/standards MH - Aged MH - *Feeding Behavior/psychology MH - Factor Analysis, Statistical PMC - PMC13434619 OTO - NOTNLM OT - Food literacy OT - Turkish adults OT - nutrition OT - psychometric validation OT - sustainability COIS- None. EDAT- 2026/06/03 12:40 MHDA- 2026/06/23 18:33 PMCR- 2026/06/03 CRDT- 2026/06/03 06:13 PHST- 2026/06/23 18:33 [medline] PHST- 2026/06/03 12:40 [pubmed] PHST- 2026/06/03 06:13 [entrez] PHST- 2026/06/03 00:00 [pmc-release] AID - S1368980026102821 [pii] AID - 10.1017/S1368980026102821 [doi] PST - epublish SO - Public Health Nutr. 2026 Jun 3;29(1):e128. doi: 10.1017/S1368980026102821. PMID- 42232628 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260603 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - A prediction nomogram for faltering catch-up growth in full-term small-for-gestational-age infants: a retrospective cohort study. PG - 1792285 LID - 10.3389/fped.2026.1792285 [doi] LID - 1792285 AB - BACKGROUND AND OBJECTIVE: Catch-up growth (CUG) before two years of age in small-for-gestational-age (SGA) infants is a key predictor of adult short stature. We aimed to establish and temporally validate a prediction nomogram for faltering CUG (FCUG) in full-term SGA infants before two years of age. METHODS: We conducted a retrospective cohort study of full-term SGA infants at West China Second University Hospital, with cohorts defined as: development (January 1996-December 2019) and temporal validation (January 2020-July 2023). Full-term SGA infants, defined by birth weight or length below 10th percentile per INTERGROWTH-21st standards (n = 1,185 in development; n = 294 in validation). FCUG was defined as failure to increase length-for-age Z score by >/=0.67 above birth Z score by 24 months. Sex, birth weight Z, birth length Z and target height Z scores were entered into a multivariable logistic model. Discrimination (AUC, sensitivity, specificity), calibration (Hosmer-Lemeshow, calibration plot), internal (1,000 bootstrap resamples) and temporal (2020-2023 cohort) validations were performed. RESULTS: In the development cohort, 280 of 1,185 (23.6%) of SGA infants experienced FCUG before age two, compared with 60 of 294 (20.4%) in the temporal validation cohort. In multivariable logistic regression analyses, male sex, lower birth length Z score, lower birth weight Z score, and lower target height Z score were all significantly associated with FCUG (all p < 0.05). These four predictors were incorporated into a nomogram. In the development cohort, the model demonstrated excellent discrimination (AUC = 0.810, 95% CI: 0.785-0.835) with a sensitivity of 74% and specificity of 74% at the optimal cut-off. Bootstrap validation (1,000 resamples) confirmed a stable AUC of 0.810. When applied to the temporal cohort, the nomogram achieved an AUC of 0.784 (95% CI: 0.730-0.838), with sensitivity of 93% and specificity of 56%. CONCLUSIONS: We have developed and temporally validated a clinically applicable nomogram that reliably identifies full-term SGA infants at high risk of failing to achieve catch-up growth by age two. With robust discrimination and calibration, this tool can support early risk stratification and guide targeted nutritional or developmental interventions. CI - (c) 2026 Hu, Yang, Li, Luo and Yang. FAU - Hu, Qian AU - Hu Q AD - Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Department of Ministry of Education, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Chengdu, China. FAU - Yang, Sufei AU - Yang S AD - Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Department of Ministry of Education, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Chengdu, China. FAU - Li, Ping AU - Li P AD - Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Department of Ministry of Education, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Chengdu, China. FAU - Luo, Jiawei AU - Luo J AD - West China Biomedical Big Data Center, West China Hospital/West China School of Medicine, Sichuan University, Chengdu, China. FAU - Yang, Fan AU - Yang F AD - Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Department of Ministry of Education, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Chengdu, China. LA - eng PT - Journal Article DEP - 20260518 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13223142 OTO - NOTNLM OT - birth length Z score OT - birth weight Z score OT - catch-up growth OT - prediction nomogram OT - small-for-gestational-age OT - target height Z score COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/03 06:35 MHDA- 2026/06/03 06:36 PMCR- 2026/05/18 CRDT- 2026/06/03 04:52 PHST- 2026/01/20 00:00 [received] PHST- 2026/04/13 00:00 [revised] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/06/03 06:36 [medline] PHST- 2026/06/03 06:35 [pubmed] PHST- 2026/06/03 04:52 [entrez] PHST- 2026/05/18 00:00 [pmc-release] AID - 10.3389/fped.2026.1792285 [doi] PST - epublish SO - Front Pediatr. 2026 May 18;14:1792285. doi: 10.3389/fped.2026.1792285. eCollection 2026. PMID- 42231839 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260813 IS - 1941-2444 (Electronic) IS - 0148-6071 (Print) IS - 0148-6071 (Linking) VI - 50 IP - 6 DP - 2026 Aug TI - The association between nutritional intakes and growth trajectories among infants with congenital diaphragmatic hernia: A retrospective cohort study. PG - 864-872 LID - 10.1002/jpen.70111 [doi] AB - BACKGROUND: Congenital diaphragmatic hernia is a critical neonatal condition frequently associated with growth impairment. Nutritional strategies to support adequate growth remain poorly defined. OBJECTIVE: To evaluate the association between caloric and protein intake, timing of parenteral and enteral nutrition, and changes in anthropometric z-scores during neonatal hospitalization in infants with congenital diaphragmatic hernia. METHODS: Retrospective cohort study including infants with congenital diaphragmatic hernia who underwent surgical repair at a single center between 2018 and 2023. Data were collected from birth to discharge or 12th week of hospitalization. Weekly deltas in anthropometric z-scores-weight-for-age, length-for-age, and head circumference-for-age-were calculated. Daily caloric and protein intakes were estimated and averaged weekly; timing of parenteral and enteral nutrition and disease-related factors were obtained and associations with anthropometric z-score deltas were analyzed. RESULTS: A total of 117 infants were included. Overall, 65% experienced z-score declines >/=0.8 across all anthropometric z-scores. Receiver operating characteristic (ROC) curve analysis identified a caloric intake of 113 kcal/kg/day as predictive of positive weight-for-age z-score deltas (area under curve 0.67) with improved specificity at 118 kcal/kg/day. In multivariable linear mixed-effects model, higher caloric intake (p < 0.001) and longer duration of mechanical ventilation (p = 0.01) were independently associated with positive weekly weight-for-age z-score deltas. Additionally, higher caloric intake was independently associated with positive weekly head circumference-for-age z-score deltas (p = 0.02). CONCLUSIONS: Growth impairment during hospitalization was highly prevalent among infants with congenital diaphragmatic hernia. A caloric intake of at least 113 kcal/kg/day, with an optimal threshold near 118 kcal/kg/day, may help prevent further deterioration in weight status. CI - (c) 2026 American Society for Parenteral and Enteral Nutrition. FAU - Villarreal, Grisell AU - Villarreal G AUID- ORCID: 0009-0006-8503-6572 AD - Department of Pediatric Gastroenterology and Nutrition, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile. FAU - Luco, Matias AU - Luco M AUID- ORCID: 0000-0002-7698-8065 AD - Department of Neonatology, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile. FAU - De Toro, Valeria AU - De Toro V AUID- ORCID: 0000-0003-4488-8753 AD - Department of Pediatric Gastroenterology and Nutrition, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile. LA - eng PT - Journal Article DEP - 20260603 PL - United States TA - JPEN J Parenter Enteral Nutr JT - JPEN. Journal of parenteral and enteral nutrition JID - 7804134 RN - 0 (Dietary Proteins) SB - IM MH - Humans MH - Retrospective Studies MH - *Hernias, Diaphragmatic, Congenital/physiopathology/therapy MH - *Energy Intake MH - Female MH - *Enteral Nutrition MH - Male MH - Infant, Newborn MH - Infant MH - *Parenteral Nutrition MH - Dietary Proteins/administration & dosage PMC - PMC13431861 OTO - NOTNLM OT - congenital diaphragmatic hernia OT - growth trajectories OT - neonatal nutrition COIS- The authors declare no conflicts of interest. EDAT- 2026/06/03 06:34 MHDA- 2026/08/03 18:37 PMCR- 2026/08/03 CRDT- 2026/06/03 04:24 PHST- 2026/03/20 00:00 [revised] PHST- 2025/06/25 00:00 [received] PHST- 2026/05/14 00:00 [accepted] PHST- 2026/08/03 18:37 [medline] PHST- 2026/06/03 06:34 [pubmed] PHST- 2026/06/03 04:24 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - JPEN70111 [pii] AID - 10.1002/jpen.70111 [doi] PST - ppublish SO - JPEN J Parenter Enteral Nutr. 2026 Aug;50(6):864-872. doi: 10.1002/jpen.70111. Epub 2026 Jun 3. PMID- 42231323 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Jun 3 TI - Artificial intelligence for predicting the pubertal growth spurt using cephalometric and hand-wrist radiographs: a systematic review and meta-analysis. LID - 10.1186/s12903-026-08627-6 [doi] LID - 1116 AB - INTRODUCTION: The optimal timing of dentofacial orthopedic and growth-modifying orthodontic interventions depends on accurate assessment of skeletal maturation, particularly the pubertal growth spurt (PGS). This systematic review and meta-analysis evaluated the performance of artificial intelligence (AI) models for identifying the PGS from cephalometric and hand-wrist radiographs and compared their diagnostic performance across imaging modalities and algorithm types. METHODS: A PRISMA 2020-guided systematic review and meta-analysis was conducted and prospectively registered in PROSPERO (CRD42024594040). PubMed, Embase, Web of Science, and LILACS were searched through December 2025. Eligible studies included individuals aged /= 41 years. Illiterate women had markedly lower odds of high knowledge (Aor = 0.280; p = 0.016) and more likely positive attitude (Aor = 3.567; p = 0.041) than those hold postgraduate certificates. Receiving breastfeeding education from relatives was significantly associated with lower odds of a positive attitude (Aor = 0.345; 95% CI: 0.167-0.715; p = 0.004), whereas a monthly income of 400,000-600,000 IQD had a positive association (COR = 1.972; 95% CI: 1.049 - 3.707; p = 0.035). CONCLUSION: Younger and less-educated mothers exhibit poorer breastfeeding knowledge and attitudes. Thus targeted health education is essential to improve breastfeeding outcomes in the region. CI - (c) 2026. The Author(s). FAU - Karim, Sharmin Abdalrahman AU - Karim SA AUID- ORCID: 0009-0001-7754-9064 AD - College of Nursing, University of Raparin, Rania, Sulaymaniyah, Kurdistan Region, Iraq. sharmn.baram@uor.edu.krd. FAU - Hamad, Sumaya Ali AU - Hamad SA AD - College of Nursing, University of Raparin, Rania, Sulaymaniyah, Kurdistan Region, Iraq. FAU - Abdulrahman, Awin Mahmud AU - Abdulrahman AM AD - College of Nursing, University of Raparin, Rania, Sulaymaniyah, Kurdistan Region, Iraq. LA - eng PT - Journal Article PT - Observational Study DEP - 20260602 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Adult MH - Female MH - Humans MH - Young Adult MH - *Breast Feeding/psychology/statistics & numerical data MH - Cross-Sectional Studies MH - *Health Knowledge, Attitudes, Practice MH - Iraq MH - *Mothers/psychology/statistics & numerical data MH - Socioeconomic Factors MH - Surveys and Questionnaires PMC - PMC13445759 OTO - NOTNLM OT - Age OT - Attitude OT - Breastfeeding OT - Infant nutrition OT - Knowledge OT - Positive predictors COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Scientific and Ethics Committees of the College of Nursing, University of Raparin, Kurdistan Region, Iraq (No. RPN/IRB/2024 - 112). Administrative permissions were also obtained from the General Directorates of Health in Raparin and Sulaimani prior to data collection. The study adheres to the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist guidelines for the transparent and standardized reporting of cross-sectional observational research. Written informed consent was obtained from all participants. The study also adhered to the ethical principles of the Declaration of Helsinki (2013), including voluntary participation, confidentiality, and the right to withdraw at any time without giving reasons. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/03 06:35 MHDA- 2026/08/06 11:36 PMCR- 2026/06/02 CRDT- 2026/06/03 01:00 PHST- 2026/02/22 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/08/06 11:36 [medline] PHST- 2026/06/03 06:35 [pubmed] PHST- 2026/06/03 01:00 [entrez] PHST- 2026/06/02 00:00 [pmc-release] AID - 10.1186/s12889-026-28031-7 [pii] AID - 28031 [pii] AID - 10.1186/s12889-026-28031-7 [doi] PST - epublish SO - BMC Public Health. 2026 Jun 2;26(1):2289. doi: 10.1186/s12889-026-28031-7. PMID- 42230735 OWN - NLM STAT- MEDLINE DCOM- 20260812 LR - 20260814 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jun 1 TI - A nomogram for risk stratification of protein-energy malnutrition in pediatric cancer patients: development and internal validation. LID - 10.1038/s41598-026-56183-4 [doi] LID - 25042 AB - To develop and internally validate a nomogram for predicting the risk of protein-energy malnutrition (PEM) in pediatric cancer patients and to evaluate its clinical utility. A total of 375 pediatric cancer patients admitted to a tertiary hospital in Xinjiang (January-May 2025) were enrolled. Nutritional status was assessed using the WHO BMI-for-age Z-score. Candidate variables (P < 0.01 in univariate analysis) were entered into the least absolute shrinkage and selection operator (LASSO) model, and multivariate logistic regression was applied to construct the prediction model. Model performance was assessed using the area under the receiver operating characteristic curve (AUC), calibration plots with the Hosmer-Lemeshow test, and decision curve analysis (DCA). Six readily obtainable variables were retained in the final model. Protective factors included being an only child (OR = 0.278), time since diagnosis of 0-6 months (OR = 0.264) or > 12 months (OR = 0.351), caregiver education of high school or above (OR = 0.406), and household per-capita income >/= 1,000 yuan (OR = 0.255). Rural residence (OR = 2.643) and >/= 6 chemotherapy cycles (OR = 2.259) were risk factors for PEM. The nomogram demonstrated robust discrimination in both the modeling (AUC = 0.823, 95% CI: 0.767-0.868) and validation (AUC = 0.779, 95% CI: 0.685-0.859) cohorts. Calibration curves showed close agreement between predicted and observed probabilities, and Hosmer-Lemeshow tests indicated good fit (all P > 0.05). DCA confirmed meaningful net clinical benefit across a wide range of threshold probabilities. The nomogram provides an interpretable and clinically practical tool for early identification of PEM risk in pediatric cancer patients, supporting targeted nutritional screening and timely intervention. CI - (c) 2026. The Author(s). FAU - Zhang, Hong AU - Zhang H AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China. FAU - Ho, Ka Yan AU - Ho KY AD - School of Nursing, The Hong Kong Polytechnic University, HKSAR, Hung Hom, China. FAU - Yorke, Janelle AU - Yorke J AD - School of Nursing, The Hong Kong Polytechnic University, HKSAR, Hung Hom, China. FAU - Mao, Ting AU - Mao T AD - School of Nursing, The Hong Kong Polytechnic University, HKSAR, Hung Hom, China. FAU - Abulaiti, Gulisumuhan AU - Abulaiti G AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China. FAU - Dong, Shuwan AU - Dong S AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, 830000, Xinjiang, China. dongshuwan2025@163.com. LA - eng GR - 2023D01C108/Natural Science Foundation of Xinjiang Uygur Autonomous Region/ PT - Journal Article DEP - 20260601 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Nomograms MH - Female MH - Child MH - Male MH - *Neoplasms/complications MH - Child, Preschool MH - *Protein-Energy Malnutrition/etiology/epidemiology/diagnosis MH - Risk Factors MH - Risk Assessment MH - Infant MH - Adolescent MH - ROC Curve MH - Nutritional Status PMC - PMC13463097 OTO - NOTNLM OT - Nomogram OT - Pediatric cancer OT - Prediction model OT - Protein-energy malnutrition COIS- Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study was approved by the Ethics Committee of the First Affiliated Hospital of Xinjiang Medical University (K202504-38), and written informed consent was obtained from all patients. EDAT- 2026/06/03 00:37 MHDA- 2026/08/12 06:05 PMCR- 2026/06/01 CRDT- 2026/06/02 23:37 PHST- 2026/01/26 00:00 [received] PHST- 2026/05/29 00:00 [accepted] PHST- 2026/08/12 06:05 [medline] PHST- 2026/06/03 00:37 [pubmed] PHST- 2026/06/02 23:37 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - 10.1038/s41598-026-56183-4 [pii] AID - 56183 [pii] AID - 10.1038/s41598-026-56183-4 [doi] PST - epublish SO - Sci Rep. 2026 Jun 1;16(1):25042. doi: 10.1038/s41598-026-56183-4. PMID- 42230619 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260813 IS - 2041-1723 (Electronic) IS - 2041-1723 (Linking) VI - 17 IP - 1 DP - 2026 Jun 2 TI - An agent-based platform for simulating the impact of chlamydia vaccine in the US population. LID - 10.1038/s41467-026-74025-9 [doi] LID - 7099 AB - Chlamydia trachomatis (CT) remains the most reported bacterial sexually transmitted infection in the United States (US), underscoring the urgent need for an effective vaccine. An agent-based model calibrated to the US National Survey of Family Growth (NSFG) and National Health and Nutrition Examination Survey (NHANES) datasets was developed and used to study the impact of vaccine on the CT and all-cause pelvic inflammatory disease (PID) burden. The model was further validated against independent epidemiological data. Here we show that a conventional vaccine with 50% efficacy and 60% coverage can achieve a 64.2% [95%CI: 43.0-68.1] reduction in chlamydia prevalence and a 14.3% [95%CI: 10.1-29.4] reduction in the prevalence of women with one or more lifetime episodes of all-cause PID. Prioritizing vaccination among individuals aged 15-24 yielded the greatest impact, even with moderate vaccine performance, highlighting the importance of age-targeted, gender-inclusive strategies. These findings provide quantitative evidence to support the design and implementation of chlamydia vaccination programs and highlight the value of agent-based modeling frameworks for evaluating complex intervention strategies in sexually transmitted infections. CI - (c) 2026. The Author(s). FAU - Deng, Qi AU - Deng Q AD - Centre of Excellence in Artificial Intelligence for Public Health Advancement, York University, Toronto, Canada. AD - Laboratory for Industrial and Applied Mathematics, York University, Toronto, Canada. FAU - Ranson, Gregoire AU - Ranson G AD - Laboratory for Industrial and Applied Mathematics, York University, Toronto, Canada. AD - Institut Camille Jordan, Universite Claude Bernard Lyon 1, Villeurbanne, France. FAU - Bragazzi, Nicola Luigi AU - Bragazzi NL AUID- ORCID: 0000-0001-8409-868X AD - Laboratory for Industrial and Applied Mathematics, York University, Toronto, Canada. AD - Department of Food and Drugs, University of Parma, Parma, Italy. AD - Department of Clinical Pharmacy, Saarland University, Saarbrucken, Germany. FAU - Castells, Valerie Bosch AU - Castells VB AD - Sanofi, Lyon, France. FAU - Chaves, Sandra S AU - Chaves SS AD - Sanofi, Lyon, France. FAU - Thommes, Edward AU - Thommes E AD - Sanofi, Toronto, Canada. AD - University of Guelph, Guelph, Ontario, Canada. FAU - Wu, Jianhong AU - Wu J AUID- ORCID: 0000-0003-0052-5336 AD - Centre of Excellence in Artificial Intelligence for Public Health Advancement, York University, Toronto, Canada. wujh@yorku.ca. AD - Laboratory for Industrial and Applied Mathematics, York University, Toronto, Canada. wujh@yorku.ca. LA - eng GR - 517504/Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (NSERC Canadian Network for Research and Innovation in Machining Technology)/ GR - 481502654/Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (NSERC Canadian Network for Research and Innovation in Machining Technology)/ PT - Journal Article DEP - 20260602 PL - England TA - Nat Commun JT - Nature communications JID - 101528555 RN - 0 (Bacterial Vaccines) SB - IM MH - Female MH - Humans MH - United States/epidemiology MH - *Chlamydia Infections/prevention & control/epidemiology/immunology/microbiology MH - *Chlamydia trachomatis/immunology MH - *Bacterial Vaccines/immunology/administration & dosage MH - Adolescent MH - Young Adult MH - Pelvic Inflammatory Disease/prevention & control/epidemiology/microbiology MH - Prevalence MH - Adult MH - Male MH - Vaccination PMC - PMC13392383 COIS- Competing interests: VBC, SSC and EWT are employees of Sanofi and may hold shares and/or stock options. The remaining authors declare no competing interests. EDAT- 2026/06/03 00:37 MHDA- 2026/07/23 05:36 PMCR- 2026/06/02 CRDT- 2026/06/02 23:27 PHST- 2025/10/30 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/07/23 05:36 [medline] PHST- 2026/06/03 00:37 [pubmed] PHST- 2026/06/02 23:27 [entrez] PHST- 2026/06/02 00:00 [pmc-release] AID - 10.1038/s41467-026-74025-9 [pii] AID - 74025 [pii] AID - 10.1038/s41467-026-74025-9 [doi] PST - epublish SO - Nat Commun. 2026 Jun 2;17(1):7099. doi: 10.1038/s41467-026-74025-9. PMID- 42230396 OWN - NLM STAT- MEDLINE DCOM- 20260605 LR - 20260922 IS - 1433-7339 (Electronic) IS - 0941-4355 (Print) IS - 0941-4355 (Linking) VI - 34 IP - 6 DP - 2026 Jun 2 TI - Nutritional status, dietary antioxidant capacity, and dietary diversity in patients with newly diagnosed hematological malignancies: a case-control study. LID - 10.1007/s00520-026-10817-5 [doi] LID - 604 AB - PURPOSE: Nutritional status and dietary antioxidant capacity are important determinants of clinical resilience in cancer; however, data in hematological malignancies remain limited. We aimed to compare nutritional status, dietary total antioxidant capacity (DTAC), and dietary diversity between patients with newly diagnosed hematological malignancies and healthy controls. METHODS: This case-control study included 34 patients with newly diagnosed hematological malignancies (12 lymphoma, 11 leukaemia, 11 multiple myeloma) and 34 age- and sex-matched healthy controls aged 18-65 years. DTAC was estimated using the ferric reducing antioxidant power (FRAP) method based on a validated food frequency questionnaire. Nutrient intakes and the dietary diversity score (DDS) were derived from 3-day dietary records. Nutritional status was assessed using the Global Leadership Initiative on Malnutrition (GLIM) criteria, along with fat-free mass index (FFMI), and mid-upper arm circumference (MUAC). RESULTS: Patients had significantly lower DTAC levels than controls (3.85 +/- 1.58 vs. 8.68 +/- 3.21 mmol/day, p < 0.05). According to GLIM criteria, 35.3% of patients had moderate malnutrition and 26.5% had severe malnutrition, A declining trend in DTAC was observed with worsening malnutrition (p = 0.034), although this did not reach the significance threshold after multiplicity adjustment. Low muscle mass was more prevalent in patients as assessed by both FFMI and MUAC. Energy, protein, zinc, vitamin E, and folate intakes were significantly lower in patients (all p < 0.05), whereas DDS did not differ (p > 0.05). DTAC was positively correlated with intakes of coffee, whole-grain bread, green vegetables, citrus fruits, and fresh fruit (p 1.28 from birth to discharge. Receiver operating characteristic (ROC) analysis was used to assess the predictive value of early feeding variables for EUGR. RESULTS: Of 1235 VLBWIs admitted, 511 (41.3%) met inclusion criteria. Mean gestational age was 28.6 +/- 1.7 weeks, and mean birth weight was 1061.2 +/- 204.3 g. Median birth weight Z-score was -0.2 (IQR -0.9 to 0.5). Mean weight growth velocity (WGV) was 13.4 +/- 6.6 g/kg/d. Median discharge weight Z-score was -0.7 (IQR -2.0 to 1.9). At discharge or transfer, 166 infants (32.4%) met the DeltaZ > 1.28 definition of EUGR, while 196 infants (38.4%) had a discharge/transfer weight Z-score below -1.28. EUGR was associated with lower birth weight, IUGR, late-onset sepsis, and longer time to regain birth weight. CONCLUSIONS: Despite successful early advancement of enteral feeding, suboptimal growth and declining Z-scores remained common. Achieving enteral feed volumes alone was insufficient to prevent EUGR, highlighting the importance of early protein and energy optimisation, timely advancement to full fortification, and routine growth monitoring in resource-limited settings. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Satardien, Muneerah AU - Satardien M AD - Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: muneerah@sun.ac.za. FAU - Van Niekerk, Evette AU - Van Niekerk E AD - Division of Human Nutrition, Department of Global Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: evettev@sun.ac.za. FAU - van Weissenbruch, Mirjam AU - van Weissenbruch M AD - Emma Children's Hospital, Division of Intensive Care Neonatology, Amsterdam UMC, Vrije Universiteit, Amsterdam, the Netherlands. Electronic address: m.vanweissenbruch@amsterdamumc.nl. FAU - Van Wyk, Lizelle AU - Van Wyk L AD - Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa. Electronic address: lizelle@sun.ac.za. LA - eng PT - Journal Article DEP - 20260601 PL - Ireland TA - Early Hum Dev JT - Early human development JID - 7708381 SB - IM MH - Humans MH - *Infant, Very Low Birth Weight/growth & development MH - South Africa MH - Infant, Newborn MH - Female MH - Retrospective Studies MH - Male MH - Parenteral Nutrition MH - *Enteral Nutrition/statistics & numerical data MH - Intensive Care Units, Neonatal/statistics & numerical data MH - Resource-Limited Settings OTO - NOTNLM OT - Enteral feeds OT - Extrauterine growth restriction OT - Growth OT - Nutrition OT - Post-natal growth failure OT - Very low birth weight infant COIS- Declaration of competing interest The authors declare that they have no competing interests. EDAT- 2026/06/03 00:39 MHDA- 2026/08/11 23:35 CRDT- 2026/06/02 18:08 PHST- 2026/04/21 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/05/31 00:00 [accepted] PHST- 2026/08/11 23:35 [medline] PHST- 2026/06/03 00:39 [pubmed] PHST- 2026/06/02 18:08 [entrez] AID - S0378-3782(26)00125-8 [pii] AID - 10.1016/j.earlhumdev.2026.106600 [doi] PST - ppublish SO - Early Hum Dev. 2026 Oct;221:106600. doi: 10.1016/j.earlhumdev.2026.106600. Epub 2026 Jun 1. PMID- 42228924 OWN - NLM STAT- Publisher LR - 20260602 IS - 1538-9774 (Electronic) IS - 1538-2931 (Linking) DP - 2026 May 27 TI - Supporting Home Care of Turkish Premature Infants: A Mobile Application Development Study. LID - 10.1097/CIN.0000000000001539 [doi] AB - The aim of this study is to develop and evaluate a mobile application called "PreBaby" adapted to the needs of Turkish mothers of premature babies. The application was developed using the analysis, design, development, implementation, and evaluation model. In the analysis phase, the topics and training areas needed by 71 mothers of premature babies during home care were determined. In the design phase, written training and 13 skill training videos were created, and the validity and comprehensibility of the content were verified by 9 experts. In the analysis phase, the following training topics were determined: nutrition, baby care, possible health problems, growth and development, baby room, sleep and dressing, vaccinations, and traditional practices. The content validity index of the training material was found to be 0.92. It was confirmed that the main menu, written training, baby care skill training videos, and sending messages to the administrator section worked well. The interface was understandable, there were simple transitions between interfaces, and ease of use. "PreBaby" has the potential to serve as an effective training tool to improve mothers' knowledge and skills regarding the care of premature babies. It is anticipated that it will contribute to the discharge education of mothers with premature babies. CI - Copyright (c) 2026 Wolters Kluwer Health, Inc. All rights reserved. FAU - Korkmaz Yenice, Gulcin AU - Korkmaz Yenice G AUID- ORCID: 0000-0002-5447-2164 AD - Department of Nursing, Yozgat Bozok University Akdagmadeni High School, Yozgat,Turkey. FAU - Esenay, Figen Isik AU - Esenay FI AUID- ORCID: 0000-0001-7576-6500 AD - Department of Pediatric Nursing, Ankara University Faculty of Nursing, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260527 PL - United States TA - Comput Inform Nurs JT - Computers, informatics, nursing : CIN JID - 101141667 SB - IM OTO - NOTNLM OT - Home care OT - Information OT - Mobile application OT - Premature COIS- There is no "conflict of interest" among the authors. EDAT- 2026/06/02 18:44 MHDA- 2026/06/02 18:44 CRDT- 2026/06/02 16:42 PHST- 2025/05/03 00:00 [received] PHST- 2026/03/05 00:00 [accepted] PHST- 2026/06/02 18:44 [medline] PHST- 2026/06/02 18:44 [pubmed] PHST- 2026/06/02 16:42 [entrez] AID - 00024665-990000000-00544 [pii] AID - 10.1097/CIN.0000000000001539 [doi] PST - aheadofprint SO - Comput Inform Nurs. 2026 May 27. doi: 10.1097/CIN.0000000000001539. PMID- 42227782 OWN - NLM STAT- MEDLINE DCOM- 20260606 LR - 20261021 IS - 2219-6749 (Electronic) IS - 0258-414X (Print) IS - 0258-414X (Linking) VI - 44 IP - 1 DP - 2026 Apr 30 TI - Assessment of the coming of age using the Caggiano method based on Demirijian stages and the Cameriere method applied to third molars in a Brazilian population. PG - 17-24 LID - 10.5281/zenodo.19689686 [doi] AB - Age estimation can be carried out through dental methods to determine whether an individual has attained legal majority. The aim of the study was to apply the methods proposed by Caggiano et al. (2022) based on Demirjian et al. (1973) stages and Cameriere et al. (2008), to third molars to estimate the legal age of 18 years, through the evaluation of panoramic radiographs in a Brazilian sample. The final sample of this study comprised 270 radiographs, including 188 from females and 82 from males, belonging to individuals aged between 16.00 and 23.99 years. After data collection, the information was organized in Microsoft Excel(c) spreadsheets and subjected to descriptive statistical analysis. The method proposed by Caggiano et al. (2022) method based on Demirjian et al. (1973) stages, proved to be more sensitive than specific. In contrast, the method proposed by Cameriere et al. (2008) showed the opposite pattern, demonstrating greater specificity than sensitivity. It can be concluded that the results showed moderate accuracy for both methods. CI - Copyright(c) 2026 IOFOS This work is published and licensed by International Organization for Forensic Odonto-Stomatology. FAU - da Silva, Mirela Cristina AU - da Silva MC AD - Department of Pathology and Legal Medicine, Ribeirao Preto Medical School, USP - University of Sao Paulo. Ribeirao Preto, Brazil. FAU - Dos Santos Moreira, Isabela AU - Dos Santos Moreira I AD - Department of Pathology and Legal Medicine, Ribeirao Preto Medical School, USP - University of Sao Paulo. Ribeirao Preto, Brazil. FAU - Jacometti, Victor AU - Jacometti V AD - Department of Pathology and Legal Medicine, Ribeirao Preto Medical School, USP - University of Sao Paulo. Ribeirao Preto, Brazil. FAU - Magri, Lais Valencise AU - Magri LV AD - Department of Restorative Dentistry, Ribeirao Preto School of Dentistry, USP - University of Sao Paulo. Ribeirao Preto, Brazil. FAU - Alves da Silva, Ricardo Henrique AU - Alves da Silva RH AUID- ORCID: 0000-0002-1532-1670 AD - Department of Stomatology, Public Health and Forensic Odontology, Ribeirao Preto School of Dentistry, USP - University of Sao Paulo. Ribeirao Preto, Brazil. LA - eng PT - Journal Article DEP - 20260430 PL - Australia TA - J Forensic Odontostomatol JT - The Journal of forensic odonto-stomatology JID - 8501421 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - *Molar, Third/diagnostic imaging/growth & development MH - *Radiography, Panoramic MH - Brazil MH - Female MH - Male MH - Adolescent MH - Young Adult MH - Forensic Dentistry/methods MH - Sensitivity and Specificity PMC - PMC13248808 OTO - NOTNLM OT - Criminal Liability OT - Dental Age Estimation OT - Forensic Odontology OT - Third Molar COIS- The authors report no conflicts of interest in this work. EDAT- 2026/06/02 12:47 MHDA- 2026/06/06 06:36 PMCR- 2026/08/01 CRDT- 2026/06/02 09:23 PHST- 2026/06/06 06:36 [medline] PHST- 2026/06/02 12:47 [pubmed] PHST- 2026/06/02 09:23 [entrez] PHST- 2026/08/01 00:00 [pmc-release] AID - JFOS-44-1-17 [pii] AID - 10.5281/zenodo.19689686 [doi] PST - epublish SO - J Forensic Odontostomatol. 2026 Apr 30;44(1):17-24. doi: 10.5281/zenodo.19689686. PMID- 42226154 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jun 1 TI - Testing the Turkish version of the breastfeeding literacy assessment instrument: a validity and reliability study. LID - 10.1186/s12884-026-09378-6 [doi] LID - 835 AB - BACKGROUND: Breastfeeding literacy is an essential component of maternal and child health, as it enables women to make informed decisions about breastfeeding practices. The objective of this study was to adapt the Breastfeeding Literacy Assessment Instrument for women in the perinatal period into Turkish and to conduct validity and reliability analyses. METHODS: This study was conducted face-to-face between September 2023 and February 2024 and involved 470 women in the perinatal period. The data were analysed and evaluated using factor analysis, Cronbach's alpha coefficients, and item-total correlations. The level of statistical significance was accepted at 0.05. RESULTS: The scale has 26 items within four subdimensions, namely Access, Understand, Appraise, and Apply. According to the factor analysis, the scale explains 55.65% of the variance with four factors. While the Cronbach's alpha value for the scale as a whole is 0.935, it varies between 0.773 and 0.860 for the subdimensions. The fit indices are as follows: chi2 = 613.82, p < 0.001, chi2/SD = 2.09, GFI = 0.82, CFI = 0.88, and RMSEA = 0.069 (95% CI: 0.061-0.077). The model fit of the Turkish version of the Breastfeeding Literacy Assessment Instrument is at an acceptable level and the scale maintained its original four-factor structure, demonstrating a robust factor structure. CONCLUSION: The Breastfeeding Literacy Assessment Instrument is a validated and reliable tool for the assessment of breastfeeding literacy among Turkish women in the perinatal period, and it can be used by health professionals. CI - (c) 2026. The Author(s). FAU - Yesilcicek Calik, Kiymet AU - Yesilcicek Calik K AUID- ORCID: 0000-0001-7146-3385 AD - Department of Obstetrics and Gynaecology Nursing, Faculty of Health Science, Karadeniz Technical University, Trabzon, Turkiye. FAU - Kucuk Erdol, Ebru AU - Kucuk Erdol E AUID- ORCID: 0000-0003-1182-7807 AD - Department of Obstetrics and Gynaecology Nursing, Faculty of Health Science, Karadeniz Technical University, Trabzon, Turkiye. ebrukucuk@ktu.edu.tr. FAU - Aygun, Ozcan AU - Aygun O AUID- ORCID: 0000-0002-4566-3292 AD - Department of Nursing, Mugla Sitki Kocman University, Mugla, Turkiye. FAU - Tayar Ozturk, Nazan AU - Tayar Ozturk N AUID- ORCID: 0000-0002-1618-8429 AD - Farabi Hospital, Karadeniz Technical University, Trabzon, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20260601 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - *Breast Feeding/psychology MH - Female MH - Turkey MH - *Health Literacy MH - Reproducibility of Results MH - Adult MH - Surveys and Questionnaires MH - Psychometrics MH - *Health Knowledge, Attitudes, Practice MH - Factor Analysis, Statistical MH - Young Adult PMC - PMC13435410 OTO - NOTNLM OT - Breastfeeding OT - Health literacy OT - Validity and reliability COIS- Declarations. Ethics approval and consent to participate: Written permission was obtained from the author of the BLAI via email to adapt it to Turkish. Prior approval for the study was obtained from the Karadeniz Technical University Health Sciences Scientific Research Ethics Committee (approval number: E-13562490-051.99-380450). Additionally, institutional permission was obtained from the institution where the study was conducted. Prior to the collection of data, all women in the study were informed about the subject matter, objective, and methodology of the research. Prior to their participation, all individuals provided written informed consent for inclusion. The study was conducted in accordance with the fundamental principles of scientific research and ethical standards for publication. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/06/02 06:36 MHDA- 2026/08/04 06:37 PMCR- 2026/06/01 CRDT- 2026/06/02 00:14 PHST- 2024/12/29 00:00 [received] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/08/04 06:37 [medline] PHST- 2026/06/02 06:36 [pubmed] PHST- 2026/06/02 00:14 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - 10.1186/s12884-026-09378-6 [pii] AID - 9378 [pii] AID - 10.1186/s12884-026-09378-6 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jun 1;26(1):835. doi: 10.1186/s12884-026-09378-6. PMID- 42226132 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jun 1 TI - Psychological correlates of mindful eating: the role of mindfulness and eating behaviors among health sciences students. LID - 10.1186/s12889-026-27982-1 [doi] LID - 2256 AB - OBJECTIVE: This study aimed to examine the associations between psychological factors, eating attitudes, and mindful eating among undergraduate health sciences students. METHODS: A cross-sectional correlational design was employed with 468 university students. Data were collected using validated self-report instruments, including the Mindful Attention Awareness Scale, Mindful Eating Questionnaire, Rosenberg Self-Esteem Scale, and Psychological Well-Being Scale-Short Form. Descriptive statistics, Spearman correlation analyses, and multiple linear regression analyses were conducted using SPSS 25.0. RESULTS: Significant positive correlations were found between mindful eating and psychological well-being (r = .298, p < .001) and mindfulness (r = .266, p < .001). Mindfulness was also positively associated with psychological well-being (r = .283, p < .001). A strong negative correlation was observed between psychological well-being and self-esteem (r = - .795, p < .001), while weak negative correlations were identified between self-esteem and both mindful eating (r = - .219, p < .001) and mindfulness (r = - .252, p < .001). In regression analyses, the overall model was statistically significant and explained a small but meaningful proportion of the variance in mindful eating (R(2) = 0.104, p < .001). Emotional eating related variables and body perception accounted for additional variance in mindful eating (R(2) = 0.047, p < .001). CONCLUSION: Mindfulness and psychological well-being were significantly associated with mindful eating, whereas self-esteem was not independently associated with mindful eating in the regression model. These findings suggest the potential importance of incorporating mindfulness- and emotion-focused components into interventions targeting eating behaviors among health sciences students. CI - (c) 2026. The Author(s). FAU - Sari, Tugba AU - Sari T AUID- ORCID: 0000-0002-5172-8662 AD - Faculty of Health Sciences, Nursing Department, Atilim University, Ankara, Turkey. tugba.sari@atilim.edu.tr. FAU - Ozel, Irem Cagla AU - Ozel IC AUID- ORCID: 0000-0002-1557-3114 AD - Faculty of Health Sciences, Nutrition and Dietetics Department, Atilim University, Ankara, Turkey. FAU - Pars, Hatice AU - Pars H AUID- ORCID: 0000-0003-4795-244X AD - Faculty of Health Sciences, Nursing Department, Yuksek Ihtisas University, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260601 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Mindfulness MH - Female MH - Cross-Sectional Studies MH - *Feeding Behavior/psychology MH - Male MH - Young Adult MH - Self Concept MH - Psychological Well-Being MH - Surveys and Questionnaires MH - *Students, Health Occupations/psychology/statistics & numerical data MH - Adult MH - Adolescent MH - *Students/psychology/statistics & numerical data MH - Universities PMC - PMC13435875 OTO - NOTNLM OT - Emotional eating OT - Mindful eating OT - Mindfulness OT - Psychological well-being OT - Self-esteem COIS- Declarations. Ethics approval and consent to participate: The study received approval from the Atilim University Ethics Committee (Approval No: 604.01-103099 Date: 10.01.2025). All participants provided written informed consent prior to participation. Participation was voluntary, and data were collected anonymously and confidentially in accordance with ethical guidelines. Consent for publication: Not applicable. The manuscript does not contain any individual person's data in any form (including individual details, images or videos). Competing interests: The authors declare no competing interests. EDAT- 2026/06/02 06:35 MHDA- 2026/08/04 06:37 PMCR- 2026/06/01 CRDT- 2026/06/02 00:13 PHST- 2025/11/17 00:00 [received] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/08/04 06:37 [medline] PHST- 2026/06/02 06:35 [pubmed] PHST- 2026/06/02 00:13 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - 10.1186/s12889-026-27982-1 [pii] AID - 27982 [pii] AID - 10.1186/s12889-026-27982-1 [doi] PST - epublish SO - BMC Public Health. 2026 Jun 1;26(1):2256. doi: 10.1186/s12889-026-27982-1. PMID- 42226021 OWN - NLM STAT- Publisher LR - 20260601 IS - 1944-7922 (Electronic) IS - 1060-3271 (Linking) DP - 2026 Jun 2 TI - Simultaneous Determination of Four Per- and Polyfluoroalkyl Substances (PFAS) in DHA Products using LC-MS/MS for Quality Control and Risk Assessment. LID - qsag045 [pii] LID - 10.1093/jaoacint/qsag045 [doi] AB - BACKGROUND: Docosahexaenoic acid (DHA) is a critical dietary supplement for vulnerable populations (e.g., infants, pregnant women), but contamination by per- and polyfluoroalkyl substances (PFAS)-persistent "forever chemicals"-poses potential health risks. Currently, no standardized methods exist for PFAS detection in DHA products, hindering quality control and risk assessment. OBJECTIVE: To develop and validate a sensitive LC-MS/MS method for simultaneous determination of four PFAS (PFOA, PFODA, PFOS, and PFBS) in DHA matrices (algal oil and fish oil) and support product safety evaluation. METHODS: Samples were extracted with 50% methanol/acetonitrile (v/v) via ultrasonication (40 degrees C, 20 min), followed by centrifugation and filtration. Chromatographic separation was achieved on a Phenomenex Kinetex F5 column (100 x 3.0 mm, 2.6 mum) with gradient elution (mobile phase: 2 mmol/L ammonium formate aqueous solution-methanol) in 12 min. Detection was performed via negative electrospray ionization (ESI-) in multiple reaction monitoring (MRM) mode. Method validation included linearity, limits of detection (LODs)/quantitation (LOQs), accuracy, precision, matrix effects, and stability. Thirteen commercial DHA products (11 algal oil, 2 fish oil) were analyzed. RESULTS: Linearity (r >/= 0.99) were achieved for PFAS; LODs/LOQs: 0.02/0.04 ng/mL. Recoveries at three spiking levels (0.1, 0.5, 1.0, 1.5 ng/mL) were ranged from 92.1%-108.4%, with RSDs of 2.8%-5.6%. Matrix effects were effectively corrected via matrix-matched calibration. Trace PFAS were detected in 3/13 samples, all below regulatory limits. CONCLUSIONS: The developed method is reliable for routine PFAS detection in DHA matrixes, providing practical technical support for quality control and risk assessment for DHA supplements for vulnerable populations. HIGHLIGHTS: Rapid (12 min), sensitive, and applicable to both algal oil and fish oil matrixes. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of AOAC INTERNATIONAL. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Zhang, Jiayi AU - Zhang J AD - Nanjing Medical University, Nanjing, 210029 China. FAU - Cao, Yanping AU - Cao Y AD - Shandong Dyne Marine Biopharmaceutical Co., Ltd, Beijing, 100176 China. FAU - Xi, Xuee AU - Xi X AD - Shandong Dyne Marine Biopharmaceutical Co., Ltd, Beijing, 100176 China. FAU - Xiao, Chaoqiang AU - Xiao C AD - Shandong Dyne Marine Biopharmaceutical Co., Ltd, Beijing, 100176 China. FAU - Zhu, Li AU - Zhu L AD - National Institutes for Food and Drug Control, Beijing, 102629 P.R. China. LA - eng PT - Journal Article DEP - 20260602 PL - England TA - J AOAC Int JT - Journal of AOAC International JID - 9215446 SB - IM OTO - NOTNLM OT - DHA OT - LC-MS/MS OT - dietary supplement OT - food safety OT - per- and polyfluoroalkyl substances (PFAS) OT - quality control EDAT- 2026/06/02 00:35 MHDA- 2026/06/02 00:35 CRDT- 2026/06/01 23:44 PHST- 2026/01/26 00:00 [received] PHST- 2026/05/06 00:00 [revised] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/06/02 00:35 [medline] PHST- 2026/06/02 00:35 [pubmed] PHST- 2026/06/01 23:44 [entrez] AID - 8699617 [pii] AID - 10.1093/jaoacint/qsag045 [doi] PST - aheadofprint SO - J AOAC Int. 2026 Jun 2:qsag045. doi: 10.1093/jaoacint/qsag045. PMID- 42226018 OWN - NLM STAT- Publisher LR - 20260601 IS - 1944-7922 (Electronic) IS - 1060-3271 (Linking) DP - 2026 Jun 2 TI - Determination of Fatty Acids at the sn-2 Position of Triacylglycerol Molecules in Infant Formula and Adult/Pediatric Nutritionals by Enzymatic Transesterification, Single-Laboratory Validation Study: First Action 2025.09. LID - qsag046 [pii] LID - 10.1093/jaoacint/qsag046 [doi] AB - BACKGROUND: The positional distribution of the fatty acids on the triacylglycerol influences uptake of calcium, fat, and energy. The positional distribution of breast milk is similar, but not identical, to that of cow and goat milk, and is different to that of vegetable oil. Often, in infant formula a mixture of milk fat with certain vegetable oils is used, to mimic the positional distribution of breast milk. A method for the analysis of fatty acids at the sn-2 position in infant formula and adult/pediatric nutritionals by enzymatic transesterification is presented. OBJECTIVE: The aim of this study is to demonstrate the suitability and applicability of the method to determine fatty acids at the sn-2 position of triacylglycerol molecules in infant formula and adult/pediatric nutritionals by enzymatic transesterification. METHODS: The sample is extracted to isolate the fat, which is treated with a regiospecific enzyme to remove the sn-1(3) positions of the triacylglycerol, resulting in 2-monoacylglycerols. These are then separated using solid phase extraction, transesterified to fatty acid methyl esters, and analyzed using gas chromatography with flame ionization detection. RESULTS: The relative standard deviation repeatability (RSDr) and intermediate precision (RSDiR) were in the range of 1.2-5.2% (RSDr) and 2.0-13.3% (RSDiR). The accuracy was assessed by spiking experiments and model triglycerides, and recoveries were on average 95% (spiked addition) and 97% (model triglycerides). The limit of quantification (LOQ) was found at 0.003 g/100g on reconstituted product. CONCLUSION: The SLV demonstrates that it meets the criteria set in the Standard Method Performance Requirements (SMPRSM) 2022.004. HIGHLIGHTS: A method to determine the content of fatty acids at the sn-2 position by use of an enzyme with good 1(3) regiospecificity was developed. The method complies to international and governmental regulations. The method was evaluated by the Expert Review Panel on Nutrient Methods, and granted first action status. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of AOAC INTERNATIONAL. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Holt, Daniella AU - Holt D AUID- ORCID: 0009-0001-2967-2682 AD - Royal FrieslandCampina, Stationsplein 4, 3818 LE Amersfoort, the Netherlands. FAU - Watanabe, Yomi AU - Watanabe Y AUID- ORCID: 0000-0003-4458-8865 AD - Osaka Research Institute of Industrial Science and Technology, 1-6-50 Morinomiya, Jotoku, Osaka, 536-8553 Japan. FAU - Golay, Pierre-Alain AU - Golay PA AUID- ORCID: 0000-0001-5328-8827 AD - Nestle Research, Vers-chez-les-Blanc, 1000 Lausanne 26, Switzerland. FAU - Cruijsen, Hans AU - Cruijsen H AUID- ORCID: 0000-0003-2405-6730 AD - Osaka Research Institute of Industrial Science and Technology, 1-6-50 Morinomiya, Jotoku, Osaka, 536-8553 Japan. FAU - Giuffrida, Francesca AU - Giuffrida F AUID- ORCID: 0000-0002-9816-3814 AD - Nestle Research, Vers-chez-les-Blanc, 1000 Lausanne 26, Switzerland. FAU - Griffon, Hugues AU - Griffon H AUID- ORCID: 0009-0006-2565-1258 AD - ITERG-Institut Des Corps Gras, Pessac, Nouvelle-Aquitaine, 33600 France, FR. LA - eng PT - Journal Article DEP - 20260602 PL - England TA - J AOAC Int JT - Journal of AOAC International JID - 9215446 SB - IM EDAT- 2026/06/02 00:35 MHDA- 2026/06/02 00:35 CRDT- 2026/06/01 23:44 PHST- 2025/12/10 00:00 [received] PHST- 2026/05/27 00:00 [revised] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/06/02 00:35 [medline] PHST- 2026/06/02 00:35 [pubmed] PHST- 2026/06/01 23:44 [entrez] AID - 8699618 [pii] AID - 10.1093/jaoacint/qsag046 [doi] PST - aheadofprint SO - J AOAC Int. 2026 Jun 2:qsag046. doi: 10.1093/jaoacint/qsag046. PMID- 42225576 OWN - NLM STAT- MEDLINE DCOM- 20260602 LR - 20260813 IS - 2005-8330 (Electronic) IS - 1229-6929 (Print) IS - 1229-6929 (Linking) VI - 27 IP - 6 DP - 2026 Jun TI - Deep Learning-Based Bone Age Assessment for Predicting Final Adult Height in Girls With Central Precocious Puberty. PG - 568-577 LID - 10.3348/kjr.2025.1221 [doi] AB - OBJECTIVE: This study aimed to evaluate the accuracy of predicting final adult height (FAH) in Korean girls with central precocious puberty (CPP) using artificial intelligence (AI)-derived bone age assessments integrated into the Bayley-Pinneau (BP) or Korean National Growth Chart (KGC) prediction models. MATERIALS AND METHODS: This single-center, retrospective study included 122 Korean girls with CPP who received gonadotropin-releasing hormone agonist (GnRHa) treatment for at least two years between January 2000 and November 2022. We assessed bone age and predicted adult height at the initiation and completion of GnRHa treatment. We used three bone age assessment methods: human expert assessment based on the Greulich-Pyle (GP) atlas (Human-GP), AI-derived GP (AI-GP), and AI-weighted GP scoring (AI-GPw). We calculated predicted adult heights (PAHs) using both the BP and KGC models, generating 12 PAH estimates per patient (2 time points x 3 bone-age methods x 2 height-prediction models). We assessed prediction accuracy and agreement with FAH using linear regression analysis and Bland-Altman plots and performed multivariable analysis to identify significant predictors of FAH. RESULTS: Human-GP, AI-GP, and AI-GPw demonstrated comparable overall performance in predicting FAH (R(2): 0.470-0.646 and 0.691-0.822 for treatment initiation and completion, respectively). AI-GPw combined with BP yielded slightly better point estimates but showed no statistically significant differences. At both time points, the BP model demonstrated consistently narrower 95% limits of agreement (LoA) than the KGC model. Multivariable analysis identified AI-GPw-BP and height percentile score as significant predictors of FAH at both time points; mid-parental height was significant only at treatment initiation. CONCLUSION: Human-GP, AI-GP, and AI-GPw demonstrated comparable accuracy in predicting FAH. The BP model demonstrated consistently narrower 95% LoA than did the KGC model. AI-GPw-BP was an independent predictor of FAH. These findings support the clinical utility of AI-derived bone age assessments for individualized FAH prediction in patients with CPP. CI - Copyright (c) 2026 The Korean Society of Radiology. FAU - Song, Jeong Min AU - Song JM AUID- ORCID: 0009-0009-0335-6903 AD - Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. FAU - Kim, Pyeong Hwa AU - Kim PH AUID- ORCID: 0000-0003-4276-8803 AD - Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. FAU - Cho, Young Ah AU - Cho YA AUID- ORCID: 0000-0001-6722-121X AD - Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. FAU - Jung, Ah Young AU - Jung AY AUID- ORCID: 0000-0002-7427-6240 AD - Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. FAU - Lee, Jin Seong AU - Lee JS AUID- ORCID: 0000-0002-8470-4595 AD - Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. FAU - Kim, Ja Hye AU - Kim JH AUID- ORCID: 0000-0002-2477-5199 AD - Department of Pediatrics, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. pedkjh@amc.seoul.kr. FAU - Yoon, Hee Mang AU - Yoon HM AUID- ORCID: 0000-0001-6491-5734 AD - Department of Radiology and Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea. espoirhm@gmail.com. LA - eng GR - HI22C1723/Korea Health Industry Development Institute/Republic of Korea GR - RS-2024-00439977/Korea Health Industry Development Institute/Republic of Korea GR - NRF-2022R1C1C1005979/NRF/National Research Foundation of Korea/Korea PT - Journal Article PL - Korea (South) TA - Korean J Radiol JT - Korean journal of radiology JID - 100956096 RN - 33515-09-2 (Gonadotropin-Releasing Hormone) SB - IM MH - Humans MH - *Puberty, Precocious/drug therapy MH - Female MH - *Deep Learning MH - Retrospective Studies MH - *Age Determination by Skeleton/methods MH - *Body Height MH - Child MH - Republic of Korea MH - Gonadotropin-Releasing Hormone/agonists MH - Predictive Value of Tests PMC - PMC13236441 OTO - NOTNLM OT - Body height OT - Bone age OT - Deep learning OT - Growth prediction OT - Precocious puberty COIS- The authors have no potential conflicts of interest to disclose. EDAT- 2026/06/02 00:36 MHDA- 2026/06/02 18:41 PMCR- 2026/06/01 CRDT- 2026/06/01 22:43 PHST- 2025/08/22 00:00 [received] PHST- 2026/02/25 00:00 [revised] PHST- 2026/02/27 00:00 [accepted] PHST- 2026/06/02 18:41 [medline] PHST- 2026/06/02 00:36 [pubmed] PHST- 2026/06/01 22:43 [entrez] PHST- 2026/06/01 00:00 [pmc-release] AID - 27.568 [pii] AID - 10.3348/kjr.2025.1221 [doi] PST - ppublish SO - Korean J Radiol. 2026 Jun;27(6):568-577. doi: 10.3348/kjr.2025.1221. PMID- 42224958 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 1873-1600 (Electronic) IS - 1466-853X (Linking) VI - 80 DP - 2026 Jul TI - Examining longitudinal changes in physical activity from 6 to 9 months after adolescent ACL reconstruction using the ACL Reasons survey. PG - 101939 LID - S1466-853X(26)00060-X [pii] LID - 10.1016/j.ptsp.2026.101939 [doi] AB - OBJECTIVES: The ACL Reasons is validated to characterize barriers to physical activity (PA) after anterior cruciate ligament reconstruction (ACLR). Understanding how perceptions of PA change after ACLR can improve patient-centered care. DESIGN: Cross-Sectional. SETTING: Academic sports medicine centers. PARTICIPANTS: 125 adolescent patients after primary ACLR (15.9 +/- 1.7years; 45.6% female). MAIN OUTCOME MEASURES: Participants completed the ACL Reasons at 6.4 +/- 0.6 months and 9.5 +/- 0.9 months post-ACLR. Individuals were categorized as 'as active', 'more challenging', and 'less active' at both time points. Activity groups were compared based on demographics and patient-reported outcome measures using one-way ANOVA and change in activity status was characterized using the Stuart-Maxwell test. RESULTS: 24.8% of participants were 'as active' as prior to injury 6 months after ACLR and 51.2% of participants were 'as active' as prior to injury at 9 months after ACLR. When grouped by activity level, there were no differences by age or sex. The pattern of change of activity level differed based on activity group at the 6 month assessment (p < .001). CONCLUSIONS: Patient-reported PA categories improve from 6-to-9 months, but 50% of patients remain less active or find activity more challenging at 9 months. Age and sex did not impact perceptions of PA. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Weaver, Adam P AU - Weaver AP AD - Department of Sports Physical Therapy, Connecticut Children's, Farmington, CT, USA; Department of Orthopedics, Connecticut Children's, Farmington, CT, USA. Electronic address: aweaver@connecticutchildrens.org. FAU - Baez, Shelby E AU - Baez SE AD - Department of Exercise Science and Sport Science, University of North Carolina, Chapel Hill, NC, USA. FAU - Rodu, Jordan Scott AU - Rodu JS AD - Department of Statistics, University of Virginia, Charlottesville, VA, USA. FAU - Kuenze, Christopher AU - Kuenze C AD - Department of Kinesiology, University of Virginia, Charlottesville, VA, USA. LA - eng PT - Journal Article DEP - 20260528 PL - England TA - Phys Ther Sport JT - Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine JID - 100940513 SB - IM MH - Humans MH - Female MH - *Anterior Cruciate Ligament Reconstruction/rehabilitation MH - Male MH - Cross-Sectional Studies MH - Adolescent MH - *Anterior Cruciate Ligament Injuries/surgery MH - *Exercise MH - Surveys and Questionnaires MH - Patient Reported Outcome Measures MH - Longitudinal Studies OTO - NOTNLM OT - ACL OT - Physical activity OT - Physical therapy OT - Psychological readiness OT - Rehabilitation COIS- Declaration of competing interest Adam Weaver, Shelby Baez, and Jordan Scott Rodu have nothing to declare. Christopher Kuenze is a paid consultant for INOVA health systems. EDAT- 2026/06/02 00:35 MHDA- 2026/07/10 18:44 CRDT- 2026/06/01 18:08 PHST- 2026/01/12 00:00 [received] PHST- 2026/05/22 00:00 [revised] PHST- 2026/05/23 00:00 [accepted] PHST- 2026/07/10 18:44 [medline] PHST- 2026/06/02 00:35 [pubmed] PHST- 2026/06/01 18:08 [entrez] AID - S1466-853X(26)00060-X [pii] AID - 10.1016/j.ptsp.2026.101939 [doi] PST - ppublish SO - Phys Ther Sport. 2026 Jul;80:101939. doi: 10.1016/j.ptsp.2026.101939. Epub 2026 May 28. PMID- 42224872 OWN - NLM STAT- MEDLINE DCOM- 20260620 LR - 20260625 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 1042 DP - 2026 Aug 1 TI - A scalable Earth observation-based machine learning framework for high-resolution mapping and uncertainty assessment of climate-sensitive child health vulnerability in Bangladesh. PG - 181919 LID - S0048-9697(26)00583-8 [pii] LID - 10.1016/j.scitotenv.2026.181919 [doi] AB - Bangladesh remains highly vulnerable to climate-induced hazards that disproportionately affect child health, yet spatially explicit assessments of these risks remain limited. This study develops a scalable Earth observation-driven machine learning framework to map climate-sensitive child health vulnerability across Bangladesh at 1-km spatial resolution. Anthropometric and health indicators from the 2022 Bangladesh Demographic and Health Survey (DHS) were integrated with multi-sensor satellite-derived environmental variables to generate high-resolution vulnerability surfaces and quantify prediction uncertainty. Georeferenced data from 674 DHS clusters (n = 8784 children) were combined with environmental covariates, including Land Surface Temperature (MODIS), precipitation (CHIRPS), vegetation indices (NDVI and EVI), and population density. Three supervised learning algorithms-Random Forest, Gradient Boosting Machine, and XGBoost-were trained using 80% of the dataset, with hyperparameters optimized through 5-fold cross-validation. The ensemble framework achieved the strongest predictive performance (R(2) = 0.683; RMSE = 7.65), outperforming individual models by 3.8%. Thermal stress, rainfall variability, and ecological productivity emerged as the dominant environmental determinants of vulnerability, collectively explaining 62% of model variance. The resulting maps revealed pronounced spatial disparities, with Rangpur exhibiting the highest vulnerability levels (67.3), while comparatively lower scores were observed in parts of Barishal and Sylhet (39.1). Bootstrap-based uncertainty analysis using 1000 iterations produced a mean uncertainty index of 4.8 +/- 1.2, with elevated uncertainty concentrated in topographically complex regions. Hotspot analysis identified vulnerable clusters encompassing approximately 6.3 million children under five. The proposed framework provides a transferable approach for precision-oriented climate-health surveillance in data-constrained regions. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Moniruzzaman, Md AU - Moniruzzaman M AD - Department of Geography and Environmental Studies, University of Rajshahi, Bangladesh. Electronic address: mzges@ru.ac.bd. LA - eng PT - Journal Article DEP - 20260601 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 SB - IM MH - Humans MH - Bangladesh MH - *Boosting Machine Learning Algorithms MH - *Child Health/statistics & numerical data MH - Climate MH - *Climate Change MH - Environmental Monitoring/methods MH - Predictive Learning Models MH - Random Forest MH - Uncertainty OTO - NOTNLM OT - Bangladesh OT - Child health vulnerability OT - Climate change impacts OT - Earth Observation OT - Ensemble machine learning OT - High-resolution mapping COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/02 00:35 MHDA- 2026/06/21 22:31 CRDT- 2026/06/01 18:04 PHST- 2026/03/16 00:00 [received] PHST- 2026/05/20 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/06/21 22:31 [medline] PHST- 2026/06/02 00:35 [pubmed] PHST- 2026/06/01 18:04 [entrez] AID - S0048-9697(26)00583-8 [pii] AID - 10.1016/j.scitotenv.2026.181919 [doi] PST - ppublish SO - Sci Total Environ. 2026 Aug 1;1042:181919. doi: 10.1016/j.scitotenv.2026.181919. Epub 2026 Jun 1. PMID- 42224506 OWN - NLM STAT- Publisher LR - 20260601 IS - 2168-6602 (Electronic) IS - 0890-1171 (Linking) DP - 2026 Jun 1 TI - Mixed Methods Evaluation of a Community-Based Weight Management Program for Latino Children. PG - 8901171261454826 LID - 10.1177/08901171261454826 [doi] AB - PurposeTo describe acceptability, feasibility, and preliminary effectiveness of a community-based weight management program for overweight/obese Latino children in immigrant families.DesignMixed methods evaluation of an exploratory single-arm pragmatic intervention trial.SettingCommunity sites in Maryland and Colorado.SampleLatino immigrant families with 5-12-year-old overweight/obese children with 93 participants (39 index children, their parents and siblings).InterventionCommunity Active and Healthy Families, an adaptation of an evidence- and behavioral-theory based, culturally tailored weight management program delivered in Spanish.Measures(1) Height and weight; (2) Surveys of sociodemographics, diet, and physical activity (PA) and (3) Parent/child interviews.Analysis(1) Pre and post means, standard deviations, differences in means and the P-value of the difference. (2) Thematic analysis of interviews.ResultsMean index child age was 9.8 years. Mean change in %BMI(p95) was -2.24 (7.49), P = 0.12. Families attended a mean of 4.5/8 program sessions. Interviews with 15 parents and 5 children demonstrated program content was acceptable, and both parent/child respondents reported liking the hands-on learning activities and child PA time. Parents reported making some recommended dietary changes and increased physical activity via family outings. Barriers to change included fresh food costs, child diet preferences and time.ConclusionOur evaluation demonstrated a preliminary signal of effectiveness, acceptability and feasibility of Community Active and Healthy Families demonstrating readiness for a larger-scale implementation and effectiveness trial. FAU - DeCamp, Lisa Ross AU - DeCamp LR AUID- ORCID: 0000-0002-5210-4675 AD - Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA. RINGGOLD: 12225 AD - Adult and Child Center for Outcomes Research and Delivery Science (ACCORDS), Aurora, CO, USA. FAU - Valdez-Vormezeele, Jenifer AU - Valdez-Vormezeele J AD - Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA. RINGGOLD: 12225 AD - Adult and Child Center for Outcomes Research and Delivery Science (ACCORDS), Aurora, CO, USA. FAU - Molino, Ellen AU - Molino E AD - Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. AD - Centro SOL, Johns Hopkins University, Baltimore, MD, USA. FAU - Musci, Rashelle AU - Musci R AD - Johns Hopkins Bloomberg School of Public Health Department of Mental Health, Baltimore, MD, USA. FAU - Vuillier, Jonathan AU - Vuillier J AD - Adult and Child Center for Outcomes Research and Delivery Science (ACCORDS), Aurora, CO, USA. FAU - Delgado Hernandez, Marina AU - Delgado Hernandez M AD - Aurora Community Connection 9801 E, Aurora, CO, USA. FAU - Marroquin Miranda, Maria Yessica AU - Marroquin Miranda MY AD - Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. AD - Centro SOL, Johns Hopkins University, Baltimore, MD, USA. FAU - Caicedo, Isabella Perea AU - Caicedo IP AD - Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD, USA. AD - Centro SOL, Johns Hopkins University, Baltimore, MD, USA. FAU - Garcia-Hernandez, Sandra AU - Garcia-Hernandez S AD - Adult and Child Center for Outcomes Research and Delivery Science (ACCORDS), Aurora, CO, USA. FAU - Huebschmann, Amy G AU - Huebschmann AG AD - Adult and Child Center for Outcomes Research and Delivery Science (ACCORDS), Aurora, CO, USA. AD - Department of Medicine, University of Colorado School of Medicine, Aurora, CO, USA. RINGGOLD: 12225 FAU - Fort, Meredith P AU - Fort MP AD - Colorado School of Public Health, Health Systems, Management and Policy, Aurora, CO, USA. RINGGOLD: 144805 FAU - Thompson, Darcy A AU - Thompson DA AD - Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA. RINGGOLD: 12225 AD - Adult and Child Center for Outcomes Research and Delivery Science (ACCORDS), Aurora, CO, USA. FAU - Perrin, Eliana AU - Perrin E AD - Department of Pediatrics, School of Medicine and School of Nursing, Johns Hopkins University, Baltimore, MD, USA. FAU - Polk, Sarah AU - Polk S AD - Department of Pediatrics, University of Colorado School of Medicine, Aurora, CO, USA. RINGGOLD: 12225 AD - Centro SOL, Johns Hopkins University, Baltimore, MD, USA. LA - eng PT - Journal Article DEP - 20260601 PL - United States TA - Am J Health Promot JT - American journal of health promotion : AJHP JID - 8701680 SB - IM OTO - NOTNLM OT - community OT - education/communications OT - health promoting community designs OT - nutrition OT - qualitative research OT - racial minority groups OT - weight control EDAT- 2026/06/01 18:49 MHDA- 2026/06/01 18:49 CRDT- 2026/06/01 15:43 PHST- 2026/06/01 18:49 [medline] PHST- 2026/06/01 18:49 [pubmed] PHST- 2026/06/01 15:43 [entrez] AID - 10.1177/08901171261454826 [doi] PST - aheadofprint SO - Am J Health Promot. 2026 Jun 1:8901171261454826. doi: 10.1177/08901171261454826. PMID- 42223658 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 6 DP - 2026 Jun 1 TI - Clinical utility of a novel index for predicting metabolic dysfunction-associated steatotic liver disease risk in children. LID - 454 [pii] LID - 10.1007/s00431-026-07107-x [doi] AB - Visceral adiposity is a key driver of metabolic dysfunction. Although indices such as the Visceral Adiposity Index (VAI) are widely used in adults, no standardized, practical tool exists for assessing visceral fat accumulation in children and adolescents. We aimed to develop a simple, clinically applicable model for the early identification of metabolic dysfunction-associated steatotic liver disease (MASLD) in pediatric obesity. We retrospectively analyzed 219 children and adolescents with obesity. Clinical, anthropometric, laboratory, and imaging data were collected. Hepatosteatosis and its severity were assessed by ultrasonography. Multivariable logistic regression models were constructed to identify independent predictors and to develop a parsimonious prediction model. The mean age was 13.34 +/- 3.17 years, and 63% were female. Anthropometric measures (body weight, BMI, waist circumference, and waist-to-height ratio) increased across steatosis grades. Metabolic markers, including insulin, AST, ALT, and HOMA-IR, showed a progressive increase with disease severity. A parsimonious model (Model 1), incorporating only age, sex, BMI SDS, and waist circumference SDS, demonstrated robust discriminative performance and outperformed HOMA-IR and adult-derived indices (VAI and TyG), which showed limited predictive utility in this population. CONCLUSION: We present a novel, anthropometry-based model that accurately identifies MASLD in children with obesity using readily available clinical parameters. This pragmatic approach enables early risk stratification and may facilitate implementation in routine pediatric practice. WHAT IS KNOWN: * Visceral adiposity is closely associated with metabolic dysfunction and increased cardiometabolic risk in children with obesity. * Anthropometric and biochemical markers have been proposed as noninvasive tools for predicting metabolic associated steatotic liver disease (MASLD) in pediatric populations. WHAT IS NEW: * Visceral adiposity-related indices were significantly associated with the presence and severity of MASLD in children and adolescents with obesity. * The study highlights the potential utility of simple anthropometric and metabolic markers in the early identification of pediatric patients at higher risk for MASLD. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Arslan, Gulcin AU - Arslan G AUID- ORCID: 0000-0003-4506-2654 AD - Department of Pediatric Endocrinology, Izmir City Hospital, Izmir, Turkey. gulcinak_005@hotmail.com. FAU - Deveci, Muge AU - Deveci M AD - Department of Pediatric Endocrinology, Izmir City Hospital, Izmir, Turkey. FAU - Er, Eren AU - Er E AD - Department of Pediatric Endocrinology, Izmir City Hospital, Izmir, Turkey. FAU - Dundar, Bumin Nuri AU - Dundar BN AD - Department of Pediatric Endocrinology, Izmir Katip Celebi Univercity, Izmir, Turkey. LA - eng PT - Journal Article DEP - 20260601 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Adolescent MH - Male MH - Retrospective Studies MH - Child MH - *Fatty Liver/etiology/diagnosis MH - *Pediatric Obesity/complications MH - Risk Factors MH - Severity of Illness Index MH - Anthropometry/methods MH - Body Mass Index MH - *Intra-Abdominal Fat MH - Risk Assessment/methods MH - Predictive Value of Tests MH - Biomarkers/blood MH - Logistic Models MH - Ultrasonography OTO - NOTNLM OT - Adiposity indices OT - Childhood obesity OT - Hepatosteatosis OT - MASLD COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/06/01 12:39 MHDA- 2026/06/01 12:40 CRDT- 2026/06/01 11:15 PHST- 2026/03/21 00:00 [received] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/05/05 00:00 [revised] PHST- 2026/06/01 12:40 [medline] PHST- 2026/06/01 12:39 [pubmed] PHST- 2026/06/01 11:15 [entrez] AID - 10.1007/s00431-026-07107-x [pii] AID - 10.1007/s00431-026-07107-x [doi] PST - epublish SO - Eur J Pediatr. 2026 Jun 1;185(6):454. doi: 10.1007/s00431-026-07107-x. PMID- 42222071 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Lipid metabolism-based machine learning models for predicting large for gestational age in non-diabetic pregnancies. PG - 1758008 LID - 10.3389/fendo.2026.1758008 [doi] LID - 1758008 AB - OBJECTIVE: The majority of LGA occurs in normoglycemic pregnancies, yet prediction models integrating lipid metabolism for this population are lacking. This study aimed to develop and validate machine learning models based on lipid metabolic profiles to predict LGA risk in non-diabetic pregnant women. METHODS: We retrospectively analyzed 1,968 singleton pregnancies without diabetes. Lipid profiles were assessed at early pregnancy (11-14 weeks) and mid-pregnancy (20-24 weeks). The dataset was randomly divided into training (n = 1,574) and independent test sets (n = 394) using stratified sampling. Four machine learning algorithms-logistic regression (LR), random forest (RF), support vector machine (SVM), and extreme gradient boosting (XGBoost)-were developed using nested 5x5 cross-validation to prevent overfitting and ensure unbiased performance estimation. Model performance was evaluated using area under the receiver operating characteristic curve (AUC), and feature importance was assessed using SHAP analysis. RESULTS: Hyperparameter optimization demonstrated stable convergence across outer folds (coefficient of variation < 1.5% for all models). On the independent test set, XGBoost achieved the highest performance with an AUC of 0.776 (95% CI: 0.730-0.822), significantly outperforming LR (AUC 0.688, P < 0.001). SHAP analysis identified pre-pregnancy BMI (mean SHAP value: 1.48), gestational weight gain (0.93), and mid-pregnancy triglycerides (0.73) as the strongest predictors. Lipid metabolism-related parameters collectively accounted for approximately 40% of the model's predictive capacity. CONCLUSIONS: Machine learning models incorporating lipid metabolic profiles demonstrated superior performance in predicting LGA among non-diabetic pregnancies. This approach enables early risk stratification and may guide personalized prenatal management. CI - Copyright (c) 2026 Liu, Xu, Mi and Yan. FAU - Liu, Wanqing AU - Liu W AD - Department of Obstetrics and Gynecology, Deyang People's Hospital, Deyang, Sichuan, China. FAU - Xu, Ya AU - Xu Y AD - Department of Obstetrics and Gynecology, Deyang People's Hospital, Deyang, Sichuan, China. FAU - Mi, Chen AU - Mi C AD - Department of Obstetrics and Gynecology, Deyang People's Hospital, Deyang, Sichuan, China. FAU - Yan, Shanling AU - Yan S AD - Department of Ultrasound, Deyang People's Hospital, Deyang, Sichuan, China. LA - eng PT - Journal Article DEP - 20260515 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Lipid Metabolism/physiology MH - Infant, Large for Gestational Age MH - Predictive Learning Models MH - Retrospective Studies MH - *Machine Learning MH - Adult MH - Boosting Machine Learning Algorithms MH - Prediction Algorithms MH - Random Forest MH - Classification Algorithms MH - Gestational Age PMC - PMC13218891 OTO - NOTNLM OT - large for gestational age OT - lipid metabolism OT - machine learning OT - non-diabetic pregnancy OT - prediction COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/01 12:38 MHDA- 2026/06/01 12:39 PMCR- 2026/05/15 CRDT- 2026/06/01 06:11 PHST- 2025/12/01 00:00 [received] PHST- 2026/04/19 00:00 [revised] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/06/01 12:39 [medline] PHST- 2026/06/01 12:38 [pubmed] PHST- 2026/06/01 06:11 [entrez] PHST- 2026/05/15 00:00 [pmc-release] AID - 10.3389/fendo.2026.1758008 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 May 15;17:1758008. doi: 10.3389/fendo.2026.1758008. eCollection 2026. PMID- 42221031 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260601 LR - 20260813 IS - 1663-4365 (Print) IS - 1663-4365 (Electronic) IS - 1663-4365 (Linking) VI - 18 DP - 2026 TI - Shaping the cognitive reserve: the role of lifelong enrichment and education in the Alzheimer's disease continuum. PG - 1736047 LID - 10.3389/fnagi.2026.1736047 [doi] LID - 1736047 AB - BACKGROUND: Leisure activities (LAs) are recognized as major contributors to cognitive reserve (CR), potentially mitigating age-related cognitive decline and dementia progression. However, the specific associations between lifelong engagement in different types of LAs, education (as a proxy of CR), and cognitive functioning along the Alzheimer's disease (AD) continuum remain poorly defined. This study aimed to investigate the association between education and LAs in relation to current cognitive performance in healthy subjects (HS), individuals with subjective cognitive decline (SCD), amnestic mild cognitive impairment (a-MCI), and AD patients. METHODS: Two hundred eighty-six participants (82 AD, 98 a-MCI, 39 SCD, 67 HS) underwent comprehensive neuropsychological testing and completed a validated questionnaire assessing the frequency of cognitive (C1-C8), social (S1-S5), and physical (P1-P5) activities during youth, middle, and late adulthood. Associations among education, LAs, and cognitive outcomes were analyzed using Spearman's correlations and moderation analyses, while between-group differences were explored with Kruskal-Wallis ANOVAs. RESULTS: Education showed significant correlations with most LA domains across all groups. Distinct activity-cognition patterns emerged along the disease continuum. In HS, participation in individual sports during youth and midlife correlated with global cognitive efficiency and memory. In SCD individuals, pet care during midlife was associated with memory, whereas in a-MCI patients, attending lectures and sewing/knitting were related to current cognitive efficiency. No significant associations were observed in AD patients. Moderation analyses revealed that education was significantly associated with the relationship between LA engagement and cognitive outcomes in HS, SCD, and a-MCI, but not in AD. Kruskal-Wallis analyses indicated reduced engagement in cognitive and social activities across disease stages compared with HS, particularly during youth and midlife. DISCUSSION: Differences in lifelong LA engagement were evident across diagnostic groups, and education was associated with variations in cognition-activity relationships. These findings suggest that the role of CR through leisure engagement may vary across disease stages. CONCLUSION: Education-related cognitive reserve was linked to the relationship between lifelong leisure activities and cognitive performance in healthy individuals and early-stage AD conditions, but not in advanced AD, highlighting the potential role of early-life cognitive, social, and physical enrichment in supporting preserved cognitive function. CI - Copyright (c) 2026 Serra, Bonarota, Di Domenico, Caruso, Rizzuti, Sperati, Tamigi, Di Lorenzo, Ricci, Laudadio, Koch, Giove, Caltagirone and Bozzali. FAU - Serra, Laura AU - Serra L AD - Department of Human Sciences, Universita degli Studi Guglielmo Marconi, Rome, Italy. AD - Neuroimaging Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy. FAU - Bonarota, Sabrina AU - Bonarota S AD - Neuroimaging Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy. FAU - Di Domenico, Carlotta AU - Di Domenico C AD - Neuroimaging Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy. AD - Department of Psychology, Sapienza University of Rome, Rome, Italy. FAU - Caruso, Giulia AU - Caruso G AD - Neuroimaging Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy. FAU - Rizzuti, Martina AU - Rizzuti M AD - Department of Human Sciences, Universita degli Studi Guglielmo Marconi, Rome, Italy. AD - Experimental and Behavioral Neurophysiology Laboratory, Fondazione Santa Lucia, Rome, Italy. FAU - Sperati, Sofia AU - Sperati S AD - Neuroimaging Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy. FAU - Tamigi, Federico Maria AU - Tamigi FM AD - Neuroimaging Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy. FAU - Di Lorenzo, Francesco AU - Di Lorenzo F AD - Experimental Neuropsychophysiology Laboratory, Fondazione Santa Lucia IRCCS, Roma, Italy. FAU - Ricci, Francesco AU - Ricci F AD - Experimental Neuropsychophysiology Laboratory, Fondazione Santa Lucia IRCCS, Roma, Italy. FAU - Laudadio, Marco AU - Laudadio M AD - Neurology 2 Unit, Department of Neurosciences "Rita Levi Montalcini", University of Turin, Torino, Italy. AD - A.O.U. Citta della Salute e Della Scienza di Torino, Turin, Italy. FAU - Koch, Giacomo AU - Koch G AD - Experimental Neuropsychophysiology Laboratory, Fondazione Santa Lucia IRCCS, Roma, Italy. AD - Department of Neuroscience and Rehabilitation University of Ferrara, Ferrara, Italy. FAU - Giove, Federico AU - Giove F AD - Neuroimaging Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy. AD - Museo Storico della Fisica e Centro Studi e Ricerche Enrico Fermi, Rome, Italy. FAU - Caltagirone, Carlo AU - Caltagirone C AD - Scientific Direction, Fondazione Santa Lucia IRCCS, Rome, Italy. FAU - Bozzali, Marco AU - Bozzali M AD - Neurology 2 Unit, Department of Neurosciences "Rita Levi Montalcini", University of Turin, Torino, Italy. AD - A.O.U. Citta della Salute e Della Scienza di Torino, Turin, Italy. LA - eng PT - Journal Article DEP - 20260514 PL - Switzerland TA - Front Aging Neurosci JT - Frontiers in aging neuroscience JID - 101525824 PMC - PMC13216489 OTO - NOTNLM OT - Alzheimer's disease OT - cognitive activities OT - cognitive reserve OT - leisure activities OT - mild cognitive impairment OT - physical activities OT - social activities OT - subjective cognitive decline COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors LS, MB declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/06/01 08:04 MHDA- 2026/06/01 08:05 PMCR- 2026/05/14 CRDT- 2026/06/01 06:00 PHST- 2025/10/30 00:00 [received] PHST- 2026/04/14 00:00 [revised] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/06/01 08:05 [medline] PHST- 2026/06/01 08:04 [pubmed] PHST- 2026/06/01 06:00 [entrez] PHST- 2026/05/14 00:00 [pmc-release] AID - 10.3389/fnagi.2026.1736047 [doi] PST - epublish SO - Front Aging Neurosci. 2026 May 14;18:1736047. doi: 10.3389/fnagi.2026.1736047. eCollection 2026. PMID- 42221003 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260601 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - The dose-response relationship between physical activity and school scoliosis screening positive in children and adolescents: a preliminary cross-sectional study. PG - 1742234 LID - 10.3389/fped.2026.1742234 [doi] LID - 1742234 AB - BACKGROUND: While physical inactivity is an established risk factor for adolescent idiopathic scoliosis (AIS), dose-response relationships for physical activity (PA) parameters remain unquantified. This study examined associations between PA dose (amount, duration, frequency, type) and scoliosis screening positive (SSP), exploring optimal thresholds. METHODS: In this cross-sectional analysis, 1,051 students (mean age 10.69 +/- 2.45 years) from 8 Shanghai schools underwent scoliometer screening (ATR >/=5 degrees defined as SSP). PA was assessed via validated The Physical Activity Questionnaire for Older Children(PAQ-C) questionnaire[scores 3: vigorous PA(VPA)]. Logistic regression modeled scoliosis risk across PA strata. Restricted cubic splines (RCS) characterized dose-response curves. Subgroup analyses explored age-specific effects. RESULTS: In two multivariable-adjusted models, both LPA and VPA demonstrated significantly elevated risks for SSP compared to MPA (adjusted OR = 3.30, 95% CI 1.92-5.68 and OR = 3.65, 95% CI 2.14-6.24, respectively), revealing a U-shaped dose-response relationship with risk nadir at PAQ-C scores approximately 2.7(p < 0.05). Exercise frequency <3 sessions/week (OR = 4.68, 95% CI 2.75-7.98), session duration < approximately 54 min or >90 min (OR = 3.43 and 2.75), and cumulative participation >2 years (OR = 3.37, 95% CI 1.89-6.01) were positively associated with SSP (p < 0.05). Aquatic sports were inversely associated with SSP(OR = 0.29, 95% CI 0.12-0.71)(p < 0.05). In addition,age-stratified analyses further indicated children (6-11y) exhibited heightened vulnerability to LPA(OR = 5.34, 95% CI 2.62-10.89), both age groups faced elevated risks fromVPA (Children OR = 5.03; Adolescents OR = 3.63), and bilateral sports (e.g., basketball) and aquatic activities universally reduced risk (OR = 0.09-0.19)(p < 0.05). CONCLUSIONS: The amount of physical activity in children and adolescents shows a U-shaped association with SSP, with moderate PA (approximately 54 min/day, 3-4 days/week) being associated with the lowest SSP odds, while low and vigorous PA are associated with higher odds. Participation in water sports and team sports is inversely associated with SSP.These findings highlight potential associations that warrant further longitudinal investigation. CI - (c) 2026 Chen, Yang, Chen and Yuan. FAU - Chen, Chen AU - Chen C AD - School of Physical Education, Sports Kinesiology, Shanghai Normal University, Shanghai, China. AD - Department of Rehabilitation Medicine, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Yang, Yang AU - Yang Y AD - School of Physical Education, Sports Kinesiology, Shanghai Normal University, Shanghai, China. FAU - Chen, Zhen AU - Chen Z AD - Department of Rehabilitation Medicine, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Yuan, Lingyan AU - Yuan L AD - School of Physical Education, Sports Kinesiology, Shanghai Normal University, Shanghai, China. LA - eng PT - Journal Article DEP - 20260514 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13216475 OTO - NOTNLM OT - adolescents OT - children OT - dose-response relationship OT - physical activity OT - scoliosis screening positive COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/06/01 08:04 MHDA- 2026/06/01 08:05 PMCR- 2026/05/14 CRDT- 2026/06/01 06:00 PHST- 2025/11/27 00:00 [received] PHST- 2026/03/19 00:00 [revised] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/06/01 08:05 [medline] PHST- 2026/06/01 08:04 [pubmed] PHST- 2026/06/01 06:00 [entrez] PHST- 2026/05/14 00:00 [pmc-release] AID - 10.3389/fped.2026.1742234 [doi] PST - epublish SO - Front Pediatr. 2026 May 14;14:1742234. doi: 10.3389/fped.2026.1742234. eCollection 2026. PMID- 42220936 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260601 LR - 20260813 IS - 2219-2808 (Print) IS - 2219-2808 (Electronic) IS - 2219-2808 (Linking) VI - 15 IP - 2 DP - 2026 Jun 9 TI - Medical treatment of autism spectrum disorder in children: Current evidence, controversies, and clinical challenges. PG - 117274 LID - 10.5409/wjcp.v15.i2.117274 [doi] LID - 117274 AB - BACKGROUND: Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition associated with debilitating comorbidities [e.g., aggression, irritability, gastrointestinal (GI) issues]. Medical management primarily targets these symptoms, as no drug is Food and Drug Administration-approved for core social-communication deficits. AIM: To synthesize the efficacy and safety of five major pharmacological classes and evaluate the emerging evidence for biomarker-driven (precision medicine) interventions in pediatric ASD. METHODS: Following PRISMA guidelines, we systematically reviewed randomized controlled trials (RCTs) for five classes: Atypical antipsychotics, stimulants, selective serotonin reuptake inhibitors, metabolic/nutritional, and microbiota-gut-brain axis agents. Quantitative meta-analysis for antipsychotics (n = 5 RCTs pooled) used the random-effects model, reporting I (2) to quantify heterogeneity. RESULTS: Atypical antipsychotics are the only drugs with robust, established efficacy for severe irritability: Pooled analysis for risperidone (n = 3 RCTs) showed a significant mean difference of approximately -11.0 on Aberrant Behavior Checklist-Irritability subscale (I (2) approximately 72%). Risperidone carries a greater metabolic burden (e.g., weight gain) than aripiprazole. Stimulants and selective serotonin reuptake inhibitors, respectively. Emerging therapies demonstrate targeted potential: Microbiota transfer therapy significantly improved GI and behavioral symptoms in cohorts with GI disease. Similarly, the efficacy of High-dose folinic acid was concentrated in the subgroup with folate receptor-alpha autoantibodies. CONCLUSION: The management of ASD demands a shift to a precision medicine model, as the efficacy of interventions is highly variable and concentrated in specific patient subgroups. Future research must prioritize the validation of biological biomarkers (metabolic, genetic, neurophysiological) to reliably predict treatment response, guiding the selection of targeted therapies, and addressing current evidence gaps. CI - (c)Author(s) 2026. FAU - Elbeltagi, Yousif M AU - Elbeltagi YM AD - Department of Medicine, The Royal College of Surgeons in Ireland - Bahrain, Busaiteen 15503, Muharraq, Bahrain. FAU - Abd Rab El Rasool, Ahmed Osama AU - Abd Rab El Rasool AO AD - Department of Neuropsychiatry, Faculty of Medicine, Tanta University, Tanta 31511, Alghrabia, Egypt. FAU - Elkashlan, Ahmed Mohammed AU - Elkashlan AM AD - Department of Medicine, Faculty of Medicine, Tanta University, Tanta 31511, Algharbia, Egypt. FAU - Al-Beltagi, Mohammed AU - Al-Beltagi M AD - Department of Pediatrics, Faculty of Medicine, Tanta University, Tanta 31511, Algharbia, Egypt. AD - Department of Paediatrics, University Hospital, Arabian Gulf University, Manama 26671, Bahrain. mohamed.elbeltagi@med.tanta.edu.eg. LA - eng PT - Journal Article DEP - 20260609 PL - United States TA - World J Clin Pediatr JT - World journal of clinical pediatrics JID - 101627548 PMC - PMC13217184 OTO - NOTNLM OT - Aripiprazole OT - Autism spectrum disorder OT - Fecal microbiota transplantation OT - Folinic acid OT - Methylcobalamin OT - Microbiota-gut-brain axis OT - Pediatric OT - Pharmacological OT - Precision medicine OT - Risperidone COIS- Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article. EDAT- 2026/06/01 08:04 MHDA- 2026/06/01 08:05 PMCR- 2026/06/09 CRDT- 2026/06/01 05:59 PHST- 2025/12/03 00:00 [received] PHST- 2025/12/13 00:00 [revised] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/06/01 08:05 [medline] PHST- 2026/06/01 08:04 [pubmed] PHST- 2026/06/01 05:59 [entrez] PHST- 2026/06/09 00:00 [pmc-release] AID - 10.5409/wjcp.v15.i2.117274 [doi] PST - epublish SO - World J Clin Pediatr. 2026 Jun 9;15(2):117274. doi: 10.5409/wjcp.v15.i2.117274. eCollection 2026 Jun 9. PMID- 42220538 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - miRNA profiling shows shared signatures in pediatric asthma, obesity and their comorbidity. PG - 1792996 LID - 10.3389/fimmu.2026.1792996 [doi] LID - 1792996 AB - RATIONALE: Childhood obesity is a known risk factor for asthma and contributes to increased disease severity and reduced corticosteroid responsiveness. However, the molecular mechanisms underlying this comorbidity remain unclear. Using a cross-sectional design, we aimed to identify microRNA (miRNA) signatures associated with asthma-obesity comorbidity in children to shed light on potential shared molecular drivers. METHODS: Whole blood samples were collected from four pediatric groups: normal weight with asthma (NW-A, n = 11), overweight/obesity with asthma (OO-A, n = 10), overweight/obesity without asthma (OO, n = 10), and normal weight without asthma (NW, n = 12). Circulating miRNA profiles were assessed using the NanoString nCounter platform. Differential expression and pathway enrichment analyses were performed using Enrichr and other bioinformatic tools. Correlation with clinical and cytokine data was assessed by Pearson's correlation and multiple regression analyses. RESULTS: miRNA expression profiles differed markedly across the four groups. Five miRNAs (miR- 423-3p, -92a-3p, -4536-5p, -197-3p, -891a-5p) were consistently upregulated, and two (miR-144-3p, -641) were downregulated across asthma alone, obesity alone, and asthma-obesity comorbidity. Target gene analysis of OO-A-associated miRNAs highlighted involvement in IL-4, IL-13, and PIP3/AKT signaling, as well as pathways linked to innate immunity and metabolism. In OO-A, miRNA dysregulation was correlated with elevated neutrophils, pro-inflammatory cytokines, and reduced lung function. CONCLUSION: In this exploratory study, we identified a shared circulating miRNA signature in asthma-obesity comorbidity. These miRNAs may serve as biomarkers and potential therapeutic targets for stratifying and managing asthma in children with obesity, pending validation in longitudinal studies. CI - Copyright (c) 2026 Shailesh, Djekidel, Noor, Hayati, Worgall, Al Khodor and Janahi. FAU - Shailesh, Harshita AU - Shailesh H AD - Department of Pediatric Medicine, Division of Pulmonology, Sidra Medicine, Doha, Qatar. FAU - Djekidel, Mohamed Nadhir AU - Djekidel MN AD - Research Department, Sidra Medicine, Doha, Qatar. FAU - Noor, Safa AU - Noor S AD - Department of Pediatric Medicine, Division of Pulmonology, Sidra Medicine, Doha, Qatar. FAU - Hayati, Lena AU - Hayati L AD - Department of Pediatric Medicine, Division of Pulmonology, Sidra Medicine, Doha, Qatar. FAU - Worgall, Stefan AU - Worgall S AD - Department of Pediatrics, Weill Cornel Medical College, New York, NY, United States. FAU - Al Khodor, Souhaila AU - Al Khodor S AD - Research Department, Sidra Medicine, Doha, Qatar. FAU - Janahi, Ibrahim AU - Janahi I AD - Department of Pediatric Medicine, Division of Pulmonology, Sidra Medicine, Doha, Qatar. AD - Department of Pediatrics, Weill Cornel Medicine-Qatar (WCM-Q), Doha, Qatar. LA - eng PT - Journal Article DEP - 20260513 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (MicroRNAs) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Asthma/genetics/epidemiology/blood MH - Female MH - Child MH - *MicroRNAs/genetics/blood MH - Gene Expression Profiling MH - Male MH - *Pediatric Obesity/genetics/epidemiology/blood MH - Comorbidity MH - Cross-Sectional Studies MH - Biomarkers MH - *Transcriptome MH - Adolescent PMC - PMC13216767 OTO - NOTNLM OT - asthma OT - biomarkers OT - children OT - miRNA profiling OT - obesity OT - pediatric COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author SK declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/06/01 08:04 MHDA- 2026/06/01 14:26 PMCR- 2026/05/13 CRDT- 2026/06/01 05:56 PHST- 2026/01/21 00:00 [received] PHST- 2026/04/24 00:00 [revised] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/06/01 14:26 [medline] PHST- 2026/06/01 08:04 [pubmed] PHST- 2026/06/01 05:56 [entrez] PHST- 2026/05/13 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1792996 [doi] PST - epublish SO - Front Immunol. 2026 May 13;17:1792996. doi: 10.3389/fimmu.2026.1792996. eCollection 2026. PMID- 42220022 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1108-7161 (Print) IS - 1108-7161 (Linking) VI - 26 IP - 2 DP - 2026 Jun 1 TI - Does a Validated Circum-menarcheal Arm Bone-Loading Index Predict Post-menarcheal Muscle Function in Adolescent Females? PG - 165-180 AB - OBJECTIVE: In this exploratory analysis, we evaluated our validated 3-year circum-menarcheal arm bone loading index (ᴀRᴍBLI) as a predictor of upper extremity muscle function indices in post-menarcheal females. METHODS: Forty-eight participants met inclusion criteria for non-dominant arm analyses, 1 to 2.5 years post-menarche: 1) menarche date (GYNAGE: yrs, menarche-centered age); 2) ᴀRᴍBLI (3-yrs prior loading exposure); 2) grip strength (kg; primary outcome), 3) Biodex peak torques (Nm: shoulder, elbow; flexion, extension; secondary outcomes), 4) DXA arm non-bone fat-free mass (ᴀRᴍNBꜰꜰᴍ, kg), 5) anthropometry [ulna length (mm), height (cm), weight (kg)]. Multiple linear regression evaluated muscle function in the total sample (n=48), gymnasts (n=24), and non-gymnasts (n=24), accounting for key factors: 1) whole-body model (GYNAGE, height, weight, ᴀRᴍBLI); 2) hypertrophy model (GYNAGE, ulna length, ᴀRᴍNBꜰꜰᴍ, ᴀRᴍBLI). RESULTS: After accounting for key factors, ᴀRᴍBLI was an independent negative predictor of grip strength in the total sample [hypertrophy model B= -0.202, p=0.029] and non-gymnast subsample [hypertrophy model B= -0.935, p=0.030; whole-body model B= -1.127, p=0.005]. Conversely, ᴀRᴍBLI was an independent positive predictor of shoulder flexion peak torque in the total sample [whole-body model B= +0.270, p=0.036]. CONCLUSIONS: Despite prior work showing ᴀRᴍBLI predicts ᴀRᴍNBꜰꜰᴍ, ᴀRᴍBLI showed inconsistent predictive value for muscle function indices. FAU - Josephson, Brian AU - Josephson B AD - Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY, USA. FAU - Chan, Timothy AU - Chan T AD - Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY, USA. FAU - Sames, Carol A AU - Sames CA AD - College of Health Professions, SUNY Upstate Medical University, Syracuse, NY, USA. FAU - Scerpella, Tamara A AU - Scerpella TA AD - Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY, USA. AD - Department of Orthopedics & Rehabilitation, University of Wisconsin-Madison, Madison, WI, USA. FAU - Dowthwaite, Jodi N AU - Dowthwaite JN AD - Department of Orthopedic Surgery, SUNY Upstate Medical University, Syracuse, NY, USA. AD - Department of Orthopedics & Rehabilitation, University of Wisconsin-Madison, Madison, WI, USA. LA - eng PT - Journal Article PL - Greece TA - J Musculoskelet Neuronal Interact JT - Journal of musculoskeletal & neuronal interactions JID - 101084496 SB - IM MH - Humans MH - Female MH - *Muscle, Skeletal/physiology MH - *Menarche/physiology MH - Adolescent MH - *Arm Bones/physiology MH - *Hand Strength/physiology MH - Child PMC - PMC13223780 OTO - NOTNLM OT - Adolescent OT - Exercise OT - Female OT - Grip Strength OT - Peak Torque COIS- The authors have no conflict of interest. EDAT- 2026/06/01 08:04 MHDA- 2026/06/01 08:05 PMCR- 2026/01/01 CRDT- 2026/06/01 03:23 PHST- 2026/06/01 08:05 [medline] PHST- 2026/06/01 08:04 [pubmed] PHST- 2026/06/01 03:23 [entrez] PHST- 2026/01/01 00:00 [pmc-release] AID - JMNI-26-02-165 [pii] AID - 10.22540/JMNI-26-165 [doi] PST - ppublish SO - J Musculoskelet Neuronal Interact. 2026 Jun 1;26(2):165-180. doi: 10.22540/JMNI-26-165. PMID- 42219649 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260717 IS - 1399-3038 (Electronic) IS - 0905-6157 (Linking) VI - 37 IP - 6 DP - 2026 Jun TI - Parental self-efficacy in food allergy management: Determinants and challenges. PG - e70391 LID - 10.1111/pai.70391 [doi] AB - BACKGROUND: Food allergy management requires dietary adherence, prevention of accidental exposures, and prompt reaction management. Identifying sociodemographic factors linked to low self-efficacy may improve management. METHODS: This study was conducted among parents of children diagnosed with food allergy who presented to our clinic. Participants completed the Turkish version of the Food Allergy Self-Efficacy Scale for Parents (T-FASE-P, previously validated as EBA-OZ) and the General Self-Efficacy Scale (GSES). RESULTS: A total of 280 parents (mothers, 85.4%; fathers, 14.6%) were included in the study. Of the children, 64.6% were boys and 35.4% were girls. The median parental age was 33 years (20-59), and the median child age was 25.5 months (3-213). Parents of children with egg and cow's milk allergy had lower T-FASE-P scores, while carrying an epinephrine auto-injector and baked egg tolerance were associated with higher scores (p < .05). Lowest scores related to school safety, cross-contamination, and travel. In multivariable analyses, only school attendance (p = .004) and cow's milk allergy (p = .002) remained significant. Subscale analyses showed that school attendance was associated with prevention and recognition/management (p = .002), parental employment with social activities (p < .001), and IgE-mediated allergy with recognition/management (p = .027), whereas cow's milk allergy was consistently associated with lower scores across all subscales (p < .05). CONCLUSION: This study evaluated parental self-efficacy in relation to demographics. Cow's milk allergy was associated with lower, and carrying an adrenaline auto-injector with higher self-efficacy. These findings emphasize the need for targeted support for families managing high-risk allergens. CI - (c) 2026 The Author(s). Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. FAU - Caliskan, Nilay AU - Caliskan N AUID- ORCID: 0000-0002-5546-0034 AD - Department of Pediatric Allergy and Immunology, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey. FAU - Sahin, Merve Karaca AU - Sahin MK AUID- ORCID: 0000-0001-8783-0514 AD - Department of Pediatric Allergy and Immunology, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey. FAU - Yildirim, Guler AU - Yildirim G AUID- ORCID: 0000-0001-7852-9252 AD - Department of Pediatric Allergy and Immunology, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey. FAU - Topcak, Asli Berivan AU - Topcak AB AD - Department of Pediatric Allergy and Immunology, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey. FAU - Karadag, Sefika Ilknur Kokcu AU - Karadag SIK AUID- ORCID: 0000-0001-9234-633X AD - Department of Pediatric Allergy and Immunology, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey. FAU - Sarman, Hasan Tunc AU - Sarman HT AUID- ORCID: 0009-0000-7234-5516 AD - Department of Pediatric Allergy and Immunology, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey. FAU - Erbay, Muhammed Fatih AU - Erbay MF AUID- ORCID: 0000-0002-4128-3081 AD - Department of Pediatric Allergy and Immunology, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey. FAU - Gungor, Hilal AU - Gungor H AUID- ORCID: 0000-0002-8923-1897 AD - Department of Pediatric Allergy and Immunology, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey. FAU - Bologur, Hamit AU - Bologur H AUID- ORCID: 0000-0003-1092-8833 AD - Department of Pediatric Allergy and Immunology, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey. FAU - Ceyhan, Zeliha AU - Ceyhan Z AUID- ORCID: 0009-0005-4960-538X AD - Department of Public Health, Ondokuz Mayis University, Samsun, Turkey. FAU - Terzi, Ozlem AU - Terzi O AUID- ORCID: 0000-0002-9524-5582 AD - Department of Public Health, Ondokuz Mayis University, Samsun, Turkey. FAU - Ozceker, Deniz AU - Ozceker D AUID- ORCID: 0000-0002-0032-6727 AD - Department of Pediatric Allergy and Immunology, Prof. Dr. Cemil Tascioglu City Hospital, Istanbul, Turkey. LA - eng PT - Journal Article PL - England TA - Pediatr Allergy Immunol JT - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JID - 9106718 RN - YKH834O4BH (Epinephrine) SB - IM MH - Humans MH - Female MH - Adult MH - Male MH - *Parents/psychology MH - *Self Efficacy MH - Infant MH - Child, Preschool MH - *Food Hypersensitivity/therapy MH - Young Adult MH - Middle Aged MH - Turkey MH - Child MH - Surveys and Questionnaires MH - Adolescent MH - Epinephrine OTO - NOTNLM OT - allergy management OT - caregiver confidence OT - cultural validation OT - food allergy OT - parental self-efficacy EDAT- 2026/06/01 08:04 MHDA- 2026/06/01 08:05 CRDT- 2026/06/01 00:32 PHST- 2026/05/06 00:00 [revised] PHST- 2025/10/11 00:00 [received] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/06/01 08:05 [medline] PHST- 2026/06/01 08:04 [pubmed] PHST- 2026/06/01 00:32 [entrez] AID - 10.1111/pai.70391 [doi] PST - ppublish SO - Pediatr Allergy Immunol. 2026 Jun;37(6):e70391. doi: 10.1111/pai.70391. PMID- 42218893 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260714 IS - 1872-7654 (Electronic) IS - 0301-2115 (Linking) VI - 324 DP - 2026 Aug TI - Maternal fragmented sleep in late pregnancy is associated with higher birthweight. PG - 115196 LID - S0301-2115(26)00264-2 [pii] LID - 10.1016/j.ejogrb.2026.115196 [doi] AB - BACKGROUND: Sleep disturbances are common during pregnancy and tend to worsen as gestation progresses. Although poor maternal sleep has been suggested to adversely affect fetal and newborn health, existing evidence remains limited and inconsistent. OBJECTIVES: To examine associations between maternal sleep disturbances during pregnancy and newborn birthweight and standardized birthweight (primary outcomes) and selected indicators of neonatal health at birth (secondary outcomes). METHODS: A total of 2,750 mothers were included in this prospective cohort study. Validated sleep questionnaires concerning sleep duration, sleep quality, insomnia symptoms, sleepiness and snoring were administered three times during pregnancy and at delivery. Associations between maternal sleep disturbances and neonatal outcomes (birthweight, standardized birthweight, 1-minute Apgar score, umbilical artery pH, and NICU admission) were evaluated using cross-sectional and exploratory longitudinal (post hoc) models, adjusted for a comprehensive set of clinically relevant covariates and corrected for multiple comparisons using FDR. RESULTS: The cohort comprised predominantly low-risk pregnant women with approximately equal proportions of nulliparous and multiparous women. Sleep quality deteriorated across gestation, with slightly shorter sleep duration, increased nocturnal awakenings, and higher insomnia scores, while changes in daytime sleepiness and perceived sleep loss were modest; neonatal outcomes were largely within normal ranges. In covariate-adjusted and FDR-corrected cross-sectional analyses, in late pregnancy, frequent nocturnal awakenings (>3 per night) were associated with higher birthweight (beta = 54.1 g, 95% CI 15.9-92.3; FDR-adjusted p = 0.012), with a similar association observed at delivery (beta = 71.0 g, 95% CI 28.6-113.4; FDR-adjusted p = 0.0049. For standardized birthweight, frequent nocturnal awakenings were associated with a higher z-score (beta = 0.15, 95% CI 0.05-0.25; FDR-adjusted p = 0.012) at delivery. A modest association between early pregnancy nocturnal awakenings and higher umbilical artery pH was observed (beta = 0.015; 95% CI 0.005-0.026; FDR-adjusted p = 0.016), within the normal physiological range. No other associations were observed in cross-sectional or longitudinal models after adjusting for confounding factors and correction for multiple testing. CONCLUSIONS: Maternal sleep quality worsened across gestation, particularly toward late pregnancy. Fragmented sleep in late pregnancy was associated with modest increases in birthweight. Nevertheless, the observed effect sizes were small, and the overall findings suggest that maternal sleep disturbances and insomnia symptoms during pregnancy are unlikely to substantially compromise fetal growth. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Parttimaa, Hilla AU - Parttimaa H AD - Department of Obstetrics and Gynecology, Turku University Hospital and University of Turku, Turku, Finland. Electronic address: himape@utu.fi. FAU - Paavonen, E Juulia AU - Paavonen EJ AD - Department of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland; Pediatric Research Center, Child Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. FAU - Perasto, Laura AU - Perasto L AD - FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku and Turku University Hospital, Turku, Finland; Centre for Population Health Research, Turku University Hospital and University of Turku, Turku, Finland. FAU - Karlsson, Hasse AU - Karlsson H AD - FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku and Turku University Hospital, Turku, Finland; Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland; Centre for Population Health Research, Turku University Hospital and University of Turku, Turku, Finland; Department of Child Psychiatry, Turku University Hospital and University of Turku, Turku, Finland. FAU - Karlsson, Linnea AU - Karlsson L AD - FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku and Turku University Hospital, Turku, Finland; Department of Public Health, University of Turku and Turku University Hospital, Turku, Finland; Centre for Population Health Research, Turku University Hospital and University of Turku, Turku, Finland; Department of Child Psychiatry, Turku University Hospital and University of Turku, Turku, Finland. FAU - Polo-Kantola, Paivi AU - Polo-Kantola P AD - Department of Obstetrics and Gynecology, Turku University Hospital and University of Turku, Turku, Finland. LA - eng PT - Journal Article DEP - 20260518 PL - Ireland TA - Eur J Obstet Gynecol Reprod Biol JT - European journal of obstetrics, gynecology, and reproductive biology JID - 0375672 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Birth Weight MH - Adult MH - Cross-Sectional Studies MH - Sleep Duration MH - *Pregnancy Complications/physiopathology MH - Infant, Newborn MH - Prospective Studies MH - *Sleep Wake Disorders/complications MH - Sleep Quality OTO - NOTNLM OT - Birthweight OT - Insomnia OT - Newborn OT - Nocturnal awakenings OT - Pregnancy OT - Sleep OT - Snoring COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/06/01 00:33 MHDA- 2026/07/14 14:02 CRDT- 2026/05/31 18:03 PHST- 2026/01/29 00:00 [received] PHST- 2026/05/13 00:00 [revised] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/07/14 14:02 [medline] PHST- 2026/06/01 00:33 [pubmed] PHST- 2026/05/31 18:03 [entrez] AID - S0301-2115(26)00264-2 [pii] AID - 10.1016/j.ejogrb.2026.115196 [doi] PST - ppublish SO - Eur J Obstet Gynecol Reprod Biol. 2026 Aug;324:115196. doi: 10.1016/j.ejogrb.2026.115196. Epub 2026 May 18. PMID- 42218482 OWN - NLM STAT- MEDLINE DCOM- 20260802 LR - 20260825 IS - 2045-709X (Electronic) IS - 2045-709X (Linking) VI - 34 IP - 1 DP - 2026 May 30 TI - Motor control exercise program versus standard care in the treatment of lumbopelvic pain in pregnant women: a randomized controlled pilot trial. LID - 10.1186/s12998-026-00655-x [doi] LID - 30 AB - BACKGROUND: Lumbopelvic pain is highly prevalent in pregnant women and although exercises are part of the strategies used to manage pregnancy-related lumbopelvic pain (PLBPP), available evidence regarding their effectiveness is inconclusive. The primary objective of this pilot study was to assess the feasibility of implementing a motor control exercise program for pregnant women presenting with a history of, or currently experiencing lumbopelvic pain. The secondary objective of the study was to explore the preliminary effectiveness of the program. METHODS: Women aged 18-40 years with a singleton pregnancy at gestational age 132.9. It had a sensitivity and specificity of 75%, but the p-value was not significant (p = 0.145). FABP4 had a cut-off of > 8.47, with a sensitivity of 86% and specificity of 68% (AUC: 0.690, 95% CI: 0.551-0.829, p = 0.015). CRI had a cut-off value of > 3.27, with a sensitivity of 60% and specificity of 79% (AUC: 0.726, 95% CI: 0.620-0.832, p = 0.001). AIP showed a cut-off value of > 0.66, with sensitivity of 59% and specificity of 73% (AUC: 0.695, 95% CI: 0.587-0.803, p = 0.001). CONCLUSION: The findings suggest that biomarkers like FABP4, AIP, and CRI may provide insights into cardiovascular risk assessment in Graves' disease. However, further studies with larger cohorts are needed to validate these associations. CI - (c) 2026. The Author(s). FAU - Bulbul, Nese AU - Bulbul N AD - Department of Endocrinology and Metabolism, Gaziantep Islam Science and Technology University, Gaziantep, Turkey. drnesebulbul@yahoo.com.tr. FAU - Yilmaz, Muge Ozsan AU - Yilmaz MO AD - Department of Endocrinology and Metabolism, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey. FAU - Oguzman, Hamdi AU - Oguzman H AD - Department of Medical Biochemistry, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey. FAU - Dogan, Serdar AU - Dogan S AD - Department of Medical Biochemistry, Faculty of Medicine, Hatay Mustafa Kemal University, Hatay, Turkey. LA - eng PT - Journal Article DEP - 20260530 PL - England TA - BMC Cardiovasc Disord JT - BMC cardiovascular disorders JID - 100968539 RN - 0 (Biomarkers) RN - 0 (Fatty Acid-Binding Proteins) RN - 63CV1GEK3Y (N,N-dimethylarginine) RN - 94ZLA3W45F (Arginine) RN - 0 (FABP4 protein, human) SB - IM MH - Humans MH - Pilot Projects MH - Female MH - Middle Aged MH - Male MH - Adult MH - Biomarkers/blood MH - Cross-Sectional Studies MH - *Fatty Acid-Binding Proteins/blood MH - Heart Disease Risk Factors MH - *Graves Disease/blood/diagnosis/complications MH - Young Adult MH - Adolescent MH - Aged MH - *Arginine/analogs & derivatives/blood MH - Risk Assessment MH - *Cardiovascular Diseases/blood/diagnosis/epidemiology/etiology MH - Risk Factors PMC - PMC13440005 OTO - NOTNLM OT - Asymmetric dimethylarginine OT - Atherogenic Index of Plasma OT - Fatty acid-binding protein 4 OT - Graves' disease OT - cardiovascular disease risk COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Mustafa Kemal University. The Declaration of Helsinki protocol was followed in the research protocol (Approval: 2022/57, Date: 01/11/2022). All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors. Study subjects were recruited only after written informed consent was obtained. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/30 00:32 MHDA- 2026/08/05 06:42 PMCR- 2026/05/30 CRDT- 2026/05/29 23:43 PHST- 2024/11/20 00:00 [received] PHST- 2026/05/28 00:00 [accepted] PHST- 2026/08/05 06:42 [medline] PHST- 2026/05/30 00:32 [pubmed] PHST- 2026/05/29 23:43 [entrez] PHST- 2026/05/30 00:00 [pmc-release] AID - 10.1186/s12872-026-06047-6 [pii] AID - 6047 [pii] AID - 10.1186/s12872-026-06047-6 [doi] PST - epublish SO - BMC Cardiovasc Disord. 2026 May 30;26(1):658. doi: 10.1186/s12872-026-06047-6. PMID- 42216059 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260827 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 27 IP - 1 DP - 2026 May 29 TI - Aerobic exercise as a therapeutic intervention for post-traumatic stress disorder in women who have experienced intimate partner violence: study protocol for an open-label randomised controlled trial. LID - 10.1186/s13063-026-09796-z [doi] LID - 513 AB - BACKGROUND: Women with a history of intimate partner violence (IPV) are at risk for post-traumatic stress disorder (PTSD). The effectiveness of aerobic exercise in reducing PTSD symptom burden has been established in other patient populations; however, its utility in the context of IPV victim-survivors has received little investigation. Therefore, the primary aim of this study is to determine if 4 weeks of daily structured aerobic exercise compared to daily stretching can reduce PTSD symptom burden in women IPV victim-survivors, offering a potential accessible and self-directed treatment avenue. METHODS: The target sample size of 120 women (aged 18-70) with a history of IPV (last instance > 3 months ago) and probable PTSD (via the PTSD Checklist for DSM-5; PCL-5) will be recruited via community advertisement in Melbourne, Australia. The trial will be completed at the Alfred Centre, Monash University. Participants will complete an exercise tolerance test via the Buffalo Concussion Bike Test and then will be randomised into either aerobic exercise or passive stretching. Participants will be instructed to complete 20 min of allocated aerobic exercise or stretching for 4 weeks and given a written diary and a Fitbit smartwatch to track program adherence. The primary outcome, PTSD symptoms via the PCL-5, will be collected at baseline, 1, 2, 3, and 4 weeks (primary endpoint). Secondary outcomes, including additional determinants of health (i.e. sleep, pain, substance use), cognitive testing, concussion-like symptoms in participants with a history of IPV-related brain injury, blood-based biomarkers, and feasibility and adherence to the prescribed program, will also be collected weekly at baseline, 1-, 2-, 3-, and 4-week follow-ups. DISCUSSION: This trial is an open-label randomised controlled trial to compare the effectiveness of a structured aerobic exercise program to passive stretching in women victim-survivors of IPV with probable PTSD. Results from this trial will help guide the development of individualised, financially accessible, and self-directed care plans for women living with PTSD and other persisting mental and physical health impacts of IPV. TRIAL REGISTRATION: ACTRN12624000893505. Trial registered retrospectively. Registered on 22/07/2024. https://anzctr.org.au/Trial/Registration/TrialReview.aspx?ACTRN=12624000893505. CI - (c) 2026. The Author(s). FAU - Copas, Charlotte AU - Copas C AD - Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia. FAU - Knight, Jen Makovec AU - Knight JM AD - Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia. AD - Monash-Epworth Rehabilitation Research Centre, Richmond, VIC, Australia. FAU - Griffith, Sarah AU - Griffith S AD - Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia. FAU - Astridge, Abigail AU - Astridge A AD - Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia. FAU - Martins, Beatriz Duarte AU - Martins BD AD - Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia. AD - Centre for Trauma and Mental Health Research, Health Sciences and Human Services, Vancouver Island University, Nanaimo, BC, Canada. FAU - McDonald, Stuart J AU - McDonald SJ AD - Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia. FAU - Chen, Zhibin AU - Chen Z AD - Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia. FAU - O'Brien, Terence J AU - O'Brien TJ AD - Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia. AD - Department of Neurology, Alfred Hospital, Melbourne, VIC, Australia. FAU - Shultz, Sandy R AU - Shultz SR AD - Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia. AD - Centre for Trauma and Mental Health Research, Health Sciences and Human Services, Vancouver Island University, Nanaimo, BC, Canada. AD - Institute on Aging & Lifelong Health, Faculty of Health, University of Victoria, Victoria, BC, Canada. FAU - Symons, Georgia F AU - Symons GF AUID- ORCID: 0000-0003-0854-7994 AD - Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, Australia. Georgia.fullersymons1@monash.edu. AD - Centre for Trauma and Mental Health Research, Health Sciences and Human Services, Vancouver Island University, Nanaimo, BC, Canada. Georgia.fullersymons1@monash.edu. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260529 PL - England TA - Trials JT - Trials JID - 101263253 SB - IM MH - Humans MH - *Stress Disorders, Post-Traumatic/therapy/psychology/diagnosis MH - Female MH - *Intimate Partner Violence/psychology MH - Adult MH - Randomized Controlled Trials as Topic MH - *Exercise Therapy/methods MH - Adolescent MH - Young Adult MH - Middle Aged MH - Treatment Outcome MH - *Exercise MH - Aged MH - Time Factors MH - Australia PMC - PMC13410850 OTO - NOTNLM OT - Domestic and family violence OT - Exercise OT - Intimate partner violence OT - Post-traumatic stress disorder COIS- Declarations. Ethics approval and consent to participate: This study has been approved by the Monash University Human Research Ethics Committee (#40295). Written, informed consent will be obtained from all participants. Competing interests: The authors declare no competing interests. EDAT- 2026/05/30 00:33 MHDA- 2026/07/30 12:43 PMCR- 2026/05/29 CRDT- 2026/05/29 23:38 PHST- 2025/11/26 00:00 [received] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/07/30 12:43 [medline] PHST- 2026/05/30 00:33 [pubmed] PHST- 2026/05/29 23:38 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - 10.1186/s13063-026-09796-z [pii] AID - 9796 [pii] AID - 10.1186/s13063-026-09796-z [doi] PST - epublish SO - Trials. 2026 May 29;27(1):513. doi: 10.1186/s13063-026-09796-z. PMID- 42215178 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260717 IS - 1876-4452 (Electronic) IS - 1355-0306 (Linking) VI - 66 IP - 3 DP - 2026 May TI - Footprint analysis in a subadult Slovak population (aged 10-18 years) for stature estimation: a preliminary study. PG - 101442 LID - S1355-0306(26)00048-1 [pii] LID - 10.1016/j.scijus.2026.101442 [doi] AB - Footprints are commonly recovered from crime scenes and accident sites. Stature estimation remains a fundamental parameter in the biological profiling of unidentified individuals, and footprint‑based methods act as an established and supplementary approach in person identification. The present cross-sectional study aims to examine the relationship between stature and footprint morphometrics in Slovak subadults and to explore their applicability in forensic anthropology caseworks and human growth research. The research included 110 subadults (58 females and 52 males) aged 10-18 years. Morphometric static footprint parameters, comprising five toe length (FPT1-FPT5), ball breadth (FPBB) and heel breadth (FPHB), along with stature, were obtained. Results indicated positive correlations of stature with all footprint variables (R = 0.366-0.894, p < 0.001), with toe lengths showing stronger associations than breadth measurements. Multiple regression models with age as a covariate demonstrated superior predictive accuracy, achieving coefficient values (R(2)) up to 0.910 in males and 0.820 in females. Footprints show potential for stature estimation in the subadult population, particularly when multiple footprint variables are included in regression models. Further investigations on larger and more diverse subadult populations along with age-based stratifications are recommended to validate and extend the outcomes of this research. CI - Copyright (c) 2026 The Chartered Society of Forensic Sciences. Published by Elsevier B.V. All rights reserved. FAU - Svabova Nee Uhrova, Petra AU - Svabova Nee Uhrova P AD - Department of Anthropology, Faculty of Natural Sciences, Comenius University, Mlynska dolina, 84215 Bratislava, Slovak Republic. Electronic address: petra.svabova@uniba.sk. FAU - Seal, Saumya AU - Seal S AD - Department of Anthropology, Faculty of Natural Sciences, Comenius University, Mlynska dolina, 84215 Bratislava, Slovak Republic. Electronic address: seal1@uniba.sk. FAU - Falbova, Darina AU - Falbova D AD - Department of Anthropology, Faculty of Natural Sciences, Comenius University, Mlynska dolina, 84215 Bratislava, Slovak Republic. Electronic address: darina.falbova@uniba.sk. FAU - Bodorikova, Silvia AU - Bodorikova S AD - Department of Anthropology, Faculty of Natural Sciences, Comenius University, Mlynska dolina, 84215 Bratislava, Slovak Republic. Electronic address: silvia.bodorikova@uniba.sk. FAU - Phamova, Dominika AU - Phamova D AD - Department of Anthropology, Faculty of Natural Sciences, Comenius University, Mlynska dolina, 84215 Bratislava, Slovak Republic. Electronic address: dphamova@hotmail.com. FAU - Fuchsova, Maria AU - Fuchsova M AD - Department of Didactics of Mathematics and Science Subjects, Faculty of Education, Comenius University Bratislava, Racianska 59, 813 34 Bratislava, Slovak Republic. Electronic address: fuchsova@fedu.uniba.sk. FAU - Benus, Radoslav AU - Benus R AD - Department of Anthropology, Faculty of Natural Sciences, Comenius University, Mlynska dolina, 84215 Bratislava, Slovak Republic; Forensic.sk Institute of Forensic Medical Expertise, Expert Institute, Bratislava, Slovak Republic. Electronic address: radoslav.benus@uniba.sk. LA - eng PT - Journal Article DEP - 20260416 PL - England TA - Sci Justice JT - Science & justice : journal of the Forensic Science Society JID - 9508563 SB - IM MH - Humans MH - Child MH - Adolescent MH - Female MH - Slovakia MH - Male MH - *Body Height MH - Forensic Anthropology MH - Cross-Sectional Studies MH - *Foot/anatomy & histology MH - Regression Analysis OTO - NOTNLM OT - Biological profile OT - Footprint morphometry OT - Forensic anthropology OT - Stature estimation OT - Subadult Slovaks COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/30 00:32 MHDA- 2026/05/30 00:33 CRDT- 2026/05/29 20:55 PHST- 2026/02/06 00:00 [received] PHST- 2026/04/05 00:00 [revised] PHST- 2026/04/15 00:00 [accepted] PHST- 2026/05/30 00:33 [medline] PHST- 2026/05/30 00:32 [pubmed] PHST- 2026/05/29 20:55 [entrez] AID - S1355-0306(26)00048-1 [pii] AID - 10.1016/j.scijus.2026.101442 [doi] PST - ppublish SO - Sci Justice. 2026 May;66(3):101442. doi: 10.1016/j.scijus.2026.101442. Epub 2026 Apr 16. PMID- 42214894 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260625 IS - 1878-5506 (Electronic) IS - 1389-9457 (Linking) VI - 145 DP - 2026 Sep TI - The impact of actigraphy parameter choices on sleep estimates in one-month-old infants. PG - 109046 LID - S1389-9457(26)00285-6 [pii] LID - 10.1016/j.sleep.2026.109046 [doi] AB - INTRODUCTION: Actigraphy is a non-invasive method of recording sleep-wake cycles. Accurate detection depends on the choice of algorithm parameters, particularly the time window and activity threshold. This study aims to compare different combination of these parameters for estimating total sleep duration and the number of sleep bouts in one-month-old infants. METHODS: Forty-nine breastfed infants (aged 24.9 +/- 3.6 days) were monitored at home for seven days. Sleep was recorded using an actigraph (MotionWatch8). Raw 60-s epochs were cross-checked with parental sleep report to correct artefactual immobility. Sleep-wake classification used 3- or 5-min windows and thresholds of 15, 20, or 40 counts. For each valid day, total sleep duration, number of sleep bouts, mean sleep bout duration and sleep-period durations were extracted. Analyses included linear mixed-effects models, Poisson regression, and plausibility screening based on pediatric literature values for sleep duration (9.3-20 h). A focused comparison between W3-T15 and W5-T15 configurations assessed sleep bout duration. RESULTS: Among the tested configurations, estimated sleep duration ranged from 15.9 to 18.1 h per day, with higher activity thresholds systematically inflating sleep duration. Threshold choice had a strong effect on total sleep duration (p < 0.001), whereas window length had minimal influence. Five-minute windows identified 50% fewer sleep bouts (p < 0.001), and produced substantially longer bout durations (p < 0.001). The W5-T15 configuration increased the proportion of sleep periods lasting 45-60-min sleep periods (7.8% vs. 5.2%, p < 0.001) and reduced the proportion of shorter periods (57.5% vs. 76.9%, p < 0.001). Overall, a threshold of 15 counts yielded the most coherent estimates. CONCLUSION: Actigraphy-derived sleep estimates in one-month-old infants are strongly influenced by the choice of activity threshold and time-window duration. Comparing six configurations revealed clear trade-offs: shorter windows increased sensitivity to brief transitions, whereas longer windows reduced fragmentation artefacts and yielded more consolidated sleep periods. These findings underscore the need for standardized parameter settings in early-infancy actigraphy and provide a reproducible basis for future methodological and validation work. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Halbouty, Zeina AU - Halbouty Z AD - PeriTox laboratory (UMR_I 01), UPJV/INERIS, Jules Verne University of Picardy, Amiens, France. Electronic address: zeinahalbouty16@gmail.com. FAU - Youbi, Lamine AU - Youbi L AD - PeriTox laboratory (UMR_I 01), UPJV/INERIS, Jules Verne University of Picardy, Amiens, France. FAU - Bach, Veronique AU - Bach V AD - PeriTox laboratory (UMR_I 01), UPJV/INERIS, Jules Verne University of Picardy, Amiens, France. FAU - Delanaud, Stephane AU - Delanaud S AD - PeriTox laboratory (UMR_I 01), UPJV/INERIS, Jules Verne University of Picardy, Amiens, France. FAU - Haraux, Elodie AU - Haraux E AD - PeriTox laboratory (UMR_I 01), UPJV/INERIS, Jules Verne University of Picardy, Amiens, France; Paediatric Surgery Unit, Amiens University Hospital, Amiens, France. FAU - Chardon, Karen AU - Chardon K AD - PeriTox laboratory (UMR_I 01), UPJV/INERIS, Jules Verne University of Picardy, Amiens, France. LA - eng PT - Journal Article DEP - 20260527 PL - Netherlands TA - Sleep Med JT - Sleep medicine JID - 100898759 SB - IM MH - Humans MH - *Actigraphy/methods MH - Infant MH - Sleep Duration MH - Female MH - Male MH - *Sleep/physiology MH - Algorithms MH - Wakefulness/physiology MH - Time Factors OTO - NOTNLM OT - Actigraphy OT - Activity threshold OT - Methodological standardization OT - One month old: time window OT - Parameter selection OT - Sleep COIS- Declaration of competing interest There is nothing to declare. EDAT- 2026/05/30 00:32 MHDA- 2026/06/13 00:38 CRDT- 2026/05/29 19:50 PHST- 2026/03/09 00:00 [received] PHST- 2026/05/26 00:00 [revised] PHST- 2026/05/26 00:00 [accepted] PHST- 2026/06/13 00:38 [medline] PHST- 2026/05/30 00:32 [pubmed] PHST- 2026/05/29 19:50 [entrez] AID - S1389-9457(26)00285-6 [pii] AID - 10.1016/j.sleep.2026.109046 [doi] PST - ppublish SO - Sleep Med. 2026 Sep;145:109046. doi: 10.1016/j.sleep.2026.109046. Epub 2026 May 27. PMID- 42214857 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260924 IS - 1873-7358 (Electronic) IS - 1471-0153 (Print) IS - 1471-0153 (Linking) VI - 62 DP - 2026 Aug TI - Athletes' relationships to training: Validation of an assessment tool across female and male athletes. PG - 102100 LID - S1471-0153(26)00033-4 [pii] LID - 10.1016/j.eatbeh.2026.102100 [doi] AB - OBJECTIVE: Reasons for exercise training are often adaptive (e.g., athletic achievement), but for some athletes, their relationship with training can include a maladaptive desire for weight loss, which can increase risk for eating-disorder pathology. Prior validation of the Athletes' Relationships to Training scale (ART) supported its validity among female athletes. The current study extended this work to compare psychometric properties of the ART among female and male athletes; we expected the measure to perform similarly across sexes. METHODS: We conducted confirmatory factor analyses (CFA) in the full sample and measurement invariance tests separated by self-reported sex in young-adult athletes from three universities (N = 424, 44.3% male, M[SD]age = 18.9[1.3] years). Pearson correlations tested associations among ART scores with other psychological symptoms to evaluate construct validity, and t-tests evaluated mean group differences in ART scores between males and females. RESULTS: The ART's four-factor structure replicated in the full sample, and in males and females separately with good fit. Results from multi-group CFA analyses supported measurement invariance between males and females. There was support for construct validity, such that overall correlations among the ART, maladaptive exercise measures, and eating-disorder pathology were higher relative to correlations with anxiety and depression. Compared to females, males scored significantly higher on the ART total and all subscale scores, with the exception of Body Dissatisfaction. DISCUSSION: Results provided preliminary evidence that the ART can be used to assess maladaptive training behaviors among both male and female young-adult athletes, thereby informing interventions designed to improve exercise motivation. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Chapa, Danielle A N AU - Chapa DAN AD - Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: iversonchapada@upmc.edu. FAU - Hagan, Kelsey E AU - Hagan KE AD - Department of Psychiatry, Virginia Commonwealth University, Richmond, VA, USA. Electronic address: kelsey.hagan@vcuhealth.org. FAU - Brown, Tiffany A AU - Brown TA AD - Department of Psychological Sciences, Auburn University, Auburn, AL, USA. Electronic address: tiffanybrown@auburn.edu. FAU - Harriger, Jennifer A AU - Harriger JA AD - Department of Social Sciences, Pepperdine University, Malibu, CA, USA. Electronic address: jennifer.harriger@pepperdine.edu. FAU - Sanzari, Christina M AU - Sanzari CM AD - Department of Psychology, University at Albany, State University of New York, Albany, NY, USA. Electronic address: csanzari@albany.edu. FAU - Hanss, Kaitlin AU - Hanss K AD - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. Electronic address: kaitlin.hanss@ucsf.edu. FAU - Flatt, Rachael E AU - Flatt RE AD - Division of Sports Medicine, Department of Orthopedics and Division of Psychology, Department of Psychiatry, Boston Children's Hospital, Boston, MA, USA. Electronic address: rachaeleflatt@gmail.com. FAU - Forbush, Kelsie T AU - Forbush KT AD - Department of Clinical Child Psychology, University of Kansas, Lawrence, KS, USA; Life Span Institute, University of Kansas, Lawrence, KS, USA. Electronic address: kforbush@ku.edu. FAU - Becker, Carolyn B AU - Becker CB AD - Department of Psychology, Trinity University, San Antonio. TX, USA. Electronic address: cbecker@trinity.edu. FAU - Farrell, Jennifer I AU - Farrell JI AD - Department of Kinesiology, University of North Carolina Greensboro, Greensboro, NC, USA. Electronic address: j_gapin@uncg.edu. FAU - Stewart, Tiffany M AU - Stewart TM AD - Pennington Biomedical Research Center/Louisiana State University, Baton Rouge, LA, USA. Electronic address: tiffany.stewart@pbrc.edu. FAU - Gorrell, Sasha AU - Gorrell S AD - Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, San Francisco, CA, USA. Electronic address: sasha.gorrell@ucsf.edu. LA - eng GR - K23 MH126201/MH/NIMH NIH HHS/United States GR - T32 MH018269/MH/NIMH NIH HHS/United States GR - R01 AG086777/AG/NIA NIH HHS/United States GR - K12 AR084233/AR/NIAMS NIH HHS/United States GR - R25 MH060482/MH/NIMH NIH HHS/United States GR - R61 MH133710/MH/NIMH NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20260528 PL - United States TA - Eat Behav JT - Eating behaviors JID - 101090048 SB - IM MH - Humans MH - Male MH - Female MH - *Athletes/psychology MH - Adolescent MH - Psychometrics MH - Young Adult MH - Reproducibility of Results MH - *Exercise/psychology MH - Surveys and Questionnaires MH - Sex Factors MH - Factor Analysis, Statistical MH - Feeding and Eating Disorders/psychology MH - Motivation PMC - PMC13344084 MID - NIHMS2190693 OTO - NOTNLM OT - Athletes OT - College athletes OT - Eating disorders OT - Male athletes OT - Motivation OT - Training COIS- Declaration of competing interest This work received no specific grant from any funding agency, commercial or not-for-profit sectors. Dr. Chapa (T32MH018269), and Dr. Brown (R61MH133710) are supported by the National Institute of Mental Health. Dr. Hagan is supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (K12AR084233). Ms. Sanzari is supported by the National Science Foundation Graduate Research Fellowship (Grant No. 1645421). Dr. Becker is supported by the National Institute of Aging (R01AG086777-01). Dr. Stewart is supported by the Department of Defense (HT94252311015) and the Wu Tsai Alliance. EDAT- 2026/05/30 00:33 MHDA- 2026/08/28 23:34 PMCR- 2026/07/09 CRDT- 2026/05/29 19:49 PHST- 2026/02/25 00:00 [received] PHST- 2026/05/26 00:00 [revised] PHST- 2026/05/27 00:00 [accepted] PHST- 2026/08/28 23:34 [medline] PHST- 2026/05/30 00:33 [pubmed] PHST- 2026/05/29 19:49 [entrez] PHST- 2026/07/09 00:00 [pmc-release] AID - S1471-0153(26)00033-4 [pii] AID - 10.1016/j.eatbeh.2026.102100 [doi] PST - ppublish SO - Eat Behav. 2026 Aug;62:102100. doi: 10.1016/j.eatbeh.2026.102100. Epub 2026 May 28. PMID- 42214814 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260728 IS - 1873-1600 (Electronic) IS - 1466-853X (Linking) VI - 80 DP - 2026 Jul TI - Assessing side-to-side injury risk and reliability of the modified landing error scoring system (LESS-M) in youth basketball athletes. PG - 101937 LID - S1466-853X(26)00058-1 [pii] LID - 10.1016/j.ptsp.2026.101937 [doi] AB - OBJECTIVE: To explore the risk of non-contact anterior cruciate ligament (ACL) injury in basketball players, with a specific focus on comparing dominant (DL) and non-dominant limbs (NDL) assessed with the LESS-M and tested the LESS-M reliability. DESIGN: Observational study. SETTING: Field-based testing. PARTICIPANTS: Thirty-six youth basketball players (31 males, 5 females; average BMI 21.35 +/- 1.98 kg/m(2)). MAIN OUTCOME MEASURES: LESS-M total scores of DL and NDL, and intraclass correlation coefficient ICC((2,1)) and ICC((2,k)) reliability. RESULTS: The LESS-M total scores were no statistically significant side-to-side difference (p = 0.327) between DL (4.11 +/- 1.16) and NDL (4.28 +/- 1.36). The LESS-M demonstrated good intra- and inter-rater reliability, with ICC((2,1)) = 0.789 and ICC((2,k)) = 0.803, respectively. CONCLUSION: The risk of non-contact ACL injury assessed using the LESS-M was similar between the DL and NDL in basketball players. The LESS-M demonstrated good reliability and may be a practical screening tool for movement assessment in basketball athletes. Future prospective studies are needed to establish cut-off values and explore its application in injured populations. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Gao, Yu AU - Gao Y AD - Biomechanics and Sports Research Unit, Faculty of Physical Therapy, Mahidol University, Nakhon Pathom, Thailand. FAU - Sinsurin, Komsak AU - Sinsurin K AD - Biomechanics and Sports Research Unit, Faculty of Physical Therapy, Mahidol University, Nakhon Pathom, Thailand. Electronic address: komsak.sin@mahidol.ac.th. FAU - Vachalathiti, Roongtiwa AU - Vachalathiti R AD - Musculoskeletal Physical Therapy Research Unit, Faculty of Physical Therapy, Mahidol University, Nakhon Pathom, Thailand. FAU - Areerak, Kantheera AU - Areerak K AD - Biomechanics and Sports Research Unit, Faculty of Physical Therapy, Mahidol University, Nakhon Pathom, Thailand. FAU - Sondang Irawan, Dimas AU - Sondang Irawan D AD - Physical Therapy Department, Faculty of Health Sciences, University of Muhammadiyah Malang, Malang, Indonesia. LA - eng PT - Journal Article PT - Observational Study DEP - 20260527 PL - England TA - Phys Ther Sport JT - Physical therapy in sport : official journal of the Association of Chartered Physiotherapists in Sports Medicine JID - 100940513 SB - IM MH - Humans MH - *Basketball/injuries MH - Reproducibility of Results MH - Female MH - Adolescent MH - *Anterior Cruciate Ligament Injuries/diagnosis MH - Male MH - Risk Assessment/methods MH - *Athletic Injuries MH - Exercise Test OTO - NOTNLM OT - Injury risk assessment OT - Jump landing OT - Lower-limb dominance OT - Movement error OT - Movement screening COIS- Declaration of competing interest The authors declare no conflicts of interest. All authors have read and agreed to the published version of the manuscript. EDAT- 2026/05/30 00:33 MHDA- 2026/07/10 12:46 CRDT- 2026/05/29 19:48 PHST- 2025/10/21 00:00 [received] PHST- 2026/05/18 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/07/10 12:46 [medline] PHST- 2026/05/30 00:33 [pubmed] PHST- 2026/05/29 19:48 [entrez] AID - S1466-853X(26)00058-1 [pii] AID - 10.1016/j.ptsp.2026.101937 [doi] PST - ppublish SO - Phys Ther Sport. 2026 Jul;80:101937. doi: 10.1016/j.ptsp.2026.101937. Epub 2026 May 27. PMID- 42214620 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260615 IS - 2341-1929 (Electronic) IS - 2341-1929 (Linking) VI - 73 IP - 6 DP - 2026 Jun-Jul TI - KETOMED Study Protocol: Ketonemia and emergence delirium in a multicenter study. PG - 502131 LID - S2341-1929(26)00119-8 [pii] LID - 10.1016/j.redare.2026.502131 [doi] AB - INTRODUCTION: Emergence Delirium (ED) following general anaesthesia affects up to a third of paediatric patients. Its multifactorial aetiology suggests that the metabolic state derived from preoperative fasting plays a significant role. Ketonemia, a physiological state associated with fasting, has been minimally investigated as an independent risk factor for ED. The KETOMED study aims to determine whether preoperative ketonemia is independently associated with the development of emergence delirium in the paediatric population. MATERIAL AND METHODS: Multicentre observational study in paediatric patients under general anaesthesia. Participants will be grouped based on the presence or absence of ED, defined using the Paediatric Anaesthesia Emergence Delirium (PAED) scale. Inclusion and exclusion criteria have been based on age, surgical type, and anaesthesia protocol. Main outcome will be ED and its association with ketone levels. Secondary outcomes include other clinical and sociodemographic risk factors and parental satisfaction. DISCUSSION: Despite the number of studies showing the beneficial role of ketone bodies in cerebral development, little is known of their potential role in the induction of ED. KETOMED addresses this issue in a robust prospective study using validated tools, including the Spanish translation of the PAED scale. CONCLUSION: KETOMED is expected to establish evidence supporting the implementation of low-cost preoperative ketonemia screening. The results have the potential to guide clinical practice regarding fasting management and clear fluid administration, ultimately aiming to reduce the incidence of ED and improve the quality and safety of paediatric anaesthetic recovery. CI - Copyright (c) 2026 Sociedad Espanola de Anestesiologia, Reanimacion y Terapeutica del Dolor. Publicado por Elsevier Espana, S.L.U. All rights reserved. FAU - Poves Alvarez, R AU - Poves Alvarez R AD - Servicio de Anestesiologia, Hospital Clinico Universitario de Valladolid, Valladolid, Spain; BioCritic. Group for Biomedical Research in Critical Care Medicine; Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain; Departamento de Cirugia, Universidad de Valladolid, Valladolid, Spain; Instituto de Investigacion Biosanitaria (IBioVall), Valladolid, Spain. FAU - Lopez-Santin, E AU - Lopez-Santin E AD - Servicio de Anestesiologia, Hospital Clinico Universitario de Valladolid, Valladolid, Spain; BioCritic. Group for Biomedical Research in Critical Care Medicine; Instituto de Investigacion Biosanitaria (IBioVall), Valladolid, Spain. Electronic address: elopezsant@saludcastillayleon.es. FAU - Martinez-Rafael, B AU - Martinez-Rafael B AD - Servicio de Anestesiologia, Hospital Clinico Universitario de Valladolid, Valladolid, Spain; BioCritic. Group for Biomedical Research in Critical Care Medicine; Departamento de Cirugia, Universidad de Valladolid, Valladolid, Spain; Instituto de Investigacion Biosanitaria (IBioVall), Valladolid, Spain. FAU - Badenes, R AU - Badenes R AD - Servicio de Anestesiologia, Hospital Clinic Universitari, Valencia, Spain; Departamento de Cirugia, Facultad de Medicina, Universidad de Valencia, Valencia, Spain; INCLIVA - Instituto de Investigacion Sanitaria, Valencia, Spain. FAU - Varela, M AU - Varela M AD - Departamento de Cirugia, Facultad de Medicina, Universidad de Santiago de Compostela, Santiago de Compostela, A Coruna, Spain; Servicio de Anestesiologia, Hospital Universitario de Pontevedra, Pontevedra, Spain; Instituto de Investigacion Sanitaria Galicia Sur (IISGS), Vigo, Pontevedra, Spain. FAU - Abad-Gurumeta, A AU - Abad-Gurumeta A AD - Servicio de Anestesiologia, Hospital Universitario Infanta Leonor, Madrid, Spain; Universidad Complutense de Madrid, Madrid, Spain. FAU - de Miguel-Manso, S AU - de Miguel-Manso S AD - Servicio de Anestesiologia, Hospital Clinico Universitario de Valladolid, Valladolid, Spain; BioCritic. Group for Biomedical Research in Critical Care Medicine; Instituto de Investigacion Biosanitaria (IBioVall), Valladolid, Spain. FAU - Minambres-Villar, M A AU - Minambres-Villar MA AD - Servicio de Anestesiologia, Hospital Clinico Universitario de Valladolid, Valladolid, Spain; BioCritic. Group for Biomedical Research in Critical Care Medicine; Instituto de Investigacion Biosanitaria (IBioVall), Valladolid, Spain. FAU - Carrasco Serrano, E AU - Carrasco Serrano E AD - Servicio de Anestesiologia, Hospital Clinico Universitario de Valladolid, Valladolid, Spain; BioCritic. Group for Biomedical Research in Critical Care Medicine; Instituto de Investigacion Biosanitaria (IBioVall), Valladolid, Spain. FAU - Fernandez-Urbon, A AU - Fernandez-Urbon A AD - Servicio de Anestesiologia, Hospital Clinico Universitario de Valladolid, Valladolid, Spain; BioCritic. Group for Biomedical Research in Critical Care Medicine; Instituto de Investigacion Biosanitaria (IBioVall), Valladolid, Spain. FAU - Tamayo, E AU - Tamayo E AD - Servicio de Anestesiologia, Hospital Clinico Universitario de Valladolid, Valladolid, Spain; BioCritic. Group for Biomedical Research in Critical Care Medicine; Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain; Departamento de Cirugia, Universidad de Valladolid, Valladolid, Spain; Instituto de Investigacion Biosanitaria (IBioVall), Valladolid, Spain. FAU - Gomez Pesquera, E AU - Gomez Pesquera E AD - Servicio de Anestesiologia, Hospital Clinico Universitario de Valladolid, Valladolid, Spain; BioCritic. Group for Biomedical Research in Critical Care Medicine; Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain; Departamento de Cirugia, Universidad de Valladolid, Valladolid, Spain; Instituto de Investigacion Biosanitaria (IBioVall), Valladolid, Spain. LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260528 PL - Spain TA - Rev Esp Anestesiol Reanim (Engl Ed) JT - Revista espanola de anestesiologia y reanimacion JID - 101778594 SB - IM MH - Humans MH - *Emergence Delirium/etiology/epidemiology MH - Pediatric Anesthesia MH - Prospective Studies MH - Child MH - *Ketosis/complications/blood/diagnosis MH - Fasting MH - *Anesthesia, General/adverse effects MH - Risk Factors MH - Child, Preschool MH - Clinical Protocols MH - Infant OTO - NOTNLM OT - Agitacion al despertar OT - Anestesia pediatrica OT - Ayuno preoperatorio OT - Cetonemia OT - Cirugia pediatrica OT - Emergence delirium OT - Ketonemia OT - Paediatric anaesthesia OT - Paediatric surgery OT - Preoperative fasting COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2026/05/30 00:33 MHDA- 2026/06/15 11:32 CRDT- 2026/05/29 19:33 PHST- 2025/12/17 00:00 [received] PHST- 2026/02/09 00:00 [revised] PHST- 2026/02/11 00:00 [accepted] PHST- 2026/06/15 11:32 [medline] PHST- 2026/05/30 00:33 [pubmed] PHST- 2026/05/29 19:33 [entrez] AID - S2341-1929(26)00119-8 [pii] AID - 10.1016/j.redare.2026.502131 [doi] PST - ppublish SO - Rev Esp Anestesiol Reanim (Engl Ed). 2026 Jun-Jul;73(6):502131. doi: 10.1016/j.redare.2026.502131. Epub 2026 May 28. PMID- 42214494 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260803 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 124 IP - 2 DP - 2026 Aug TI - Comparative lipidomic study reveals distinct triacylglycerol composition and molecular species in human milk and maternal-fetal circulation. PG - 101381 LID - S0002-9165(26)00190-5 [pii] LID - 10.1016/j.ajcnut.2026.101381 [doi] AB - BACKGROUND: The structural organization of fatty acids within triacylglycerols (TAGs), particularly at the sn-2 position, determines their metabolic fate. Whether the TAG architecture in human milk, the sole nutrition for infants, is distinct from that in maternal and fetal circulation remains unclear. OBJECTIVES: We conducted a comparative lipidomic analysis to characterize the molecular and regioisomeric profiles of TAGs across human milk (at 3 lactation stages) and paired maternal/cord plasma. METHODS: TAGs from milk (colostrum, transitional, mature; n = 87) and plasma (maternal and cord; n = 58) of 29 mother-infant dyads were analyzed using ultraperformance supercritical fluid chromatography quadrupole time-of-flight mass spectrometry. Regioisomers were quantified via a validated computational model. RESULTS: Human milk TAGs exhibited a unique compositional and structural profile compared with circulatory TAGs. A key finding was the preferential positioning of docosahexaenoic acid (DHA) at the sn-2 position in major human milk TAGs (e.g., >65% in DHA/O/O), whereas in cord plasma, DHA in analogous TAGs was exclusively at the sn-1/3 positions (P < 0.001). Similarly, palmitic acid (16:0) was predominantly at sn-2 in milk TAGs (>90% in major species) but not in plasma (<35%). Cord plasma was enriched in long-chain polyunsaturated fatty acids (8.2% compared with 2.5% in maternal plasma, P < 0.05; all tests 2-sided) carried by distinct TAG species. CONCLUSIONS: Human milk shows a unique TAG architecture characterized by a conserved sn-2 enrichment of both DHA and palmitic acid, fundamentally different from the TAG regioisomer profiles in maternal-fetal circulation. This sn-2-DHA-rich structure in milk lipids may represent a tailored metabolic design to support neonatal development. CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Jiang, Chenyu AU - Jiang C AD - State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi, China. FAU - Zhang, Xinghe AU - Zhang X AD - State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi, China. FAU - Wang, Xingguo AU - Wang X AD - State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi, China. FAU - Zhu, Huilian AU - Zhu H AD - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China. FAU - Yang, Mengtao AU - Yang M AD - Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, China. Electronic address: yangmt27@mail.sysu.edu.cn. FAU - Wei, Wei AU - Wei W AD - State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi, China; Collaborative Innovation Center of Food Safety and Quality Control in Jiangsu Province, School of Food Science and Technology, Jiangnan University, Wuxi, China. Electronic address: weiw@jiangnan.edu.cn. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260528 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 RN - 0 (Triglycerides) RN - 25167-62-8 (Docosahexaenoic Acids) RN - 0 (Fatty Acids) SB - IM MH - Humans MH - *Milk, Human/chemistry MH - *Triglycerides/chemistry/blood/metabolism MH - Female MH - Lipidomics MH - *Fetal Blood/chemistry MH - Adult MH - Docosahexaenoic Acids/blood MH - Infant, Newborn MH - Pregnancy MH - Lactation MH - Fatty Acids/chemistry MH - Infant MH - Colostrum/chemistry OTO - NOTNLM OT - DHA OT - cord plasma OT - human milk OT - infant nutrition OT - lipidomics OT - maternal plasma OT - sn-2 position OT - triacylglycerol COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/05/30 00:33 MHDA- 2026/08/04 00:35 CRDT- 2026/05/29 19:32 PHST- 2026/02/02 00:00 [received] PHST- 2026/05/18 00:00 [revised] PHST- 2026/05/23 00:00 [accepted] PHST- 2026/08/04 00:35 [medline] PHST- 2026/05/30 00:33 [pubmed] PHST- 2026/05/29 19:32 [entrez] AID - S0002-9165(26)00190-5 [pii] AID - 10.1016/j.ajcnut.2026.101381 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Aug;124(2):101381. doi: 10.1016/j.ajcnut.2026.101381. Epub 2026 May 28. PMID- 42214444 OWN - NLM STAT- Publisher LR - 20260529 IS - 1098-8947 (Electronic) IS - 0743-684X (Linking) DP - 2026 May 29 TI - Beyond the Chest X-Ray: Comparative Performance of Preoperative Tests for Phrenic Nerve Dysfunction in Brachial Plexus Injuries. LID - 10.1055/a-2880-0545 [doi] AB - BACKGROUND: The phrenic nerve, arising from C3-C5 and innervating the diaphragm, is frequently affected in brachial plexus injuries (BPI). Given its role in respiration, preoperative assessment is essential to anticipate respiratory compromise in high-risk patients (e.g., elderly, obese, pediatric, smokers) and to determine its suitability as a donor nerve in selected cases. Traditional tests such as inspiratory-expiratory chest radiographs (CXR) are commonly used but have limited sensitivity. More recent modalities-including chest sonography, pulmonary function testing (PFT), and magnetic resonance neurography (MRN)-have been described, though their relative performance in BPI remains unclear. This study systematically compared these methods against intraoperative phrenic nerve stimulation as the reference standard. METHODS: A retrospective review was performed of patients undergoing brachial plexus reconstruction between 2020 and 2024. Inclusion required documented intraoperative phrenic nerve stimulation and at least one preoperative diagnostic test. Sensitivity, specificity, accuracy, and area under the receiver operating characteristic curve (AUC) were calculated. McNemar's test assessed diagnostic agreement, DeLong's test compared AUCs, and logistic regression identified predictors of phrenic nerve injury. RESULTS: Among 113 patients, chest sonography provided the highest diagnostic accuracy, with 100% sensitivity, 80% specificity, and an AUC of 0.900. CXR showed the greatest specificity (93%) but low sensitivity (44%), yielding an AUC of 0.687. PFT demonstrated moderate sensitivity (86%) and low specificity (58%), with an AUC of 0.718. MRN performed poorly: MRN of the injured C4 root showed 22.2% sensitivity, 84.4% specificity, and an AUC of 0.533, while MRN of the injured C5 root yielded high sensitivity (87%) but very low specificity (6.5%), with an AUC of 0.467. CONCLUSION: Chest sonography provides the most reliable assessment of phrenic nerve function in BPI. Although CXR offers high specificity, its low sensitivity limits its use as a standalone test. A combined approach with sonography and CXR may enhance diagnostic accuracy. CI - Thieme. All rights reserved. FAU - Yen, Patrick Szu-Ying AU - Yen PS AD - Taiwan, and Chang Gung University, Chang Gung Memorial Hospital, Department of Plastic and Reconstructive Surgery, Taiwan. FAU - Lee, Che-Hsiung AU - Lee CH AD - Taiwan, and Chang Gung University, Chang Gung Memorial Hospital, Department of Plastic and Reconstructive Surgery, Taiwan. FAU - Adidharma, Widya AU - Adidharma W AD - University of Michigan Medical School, Section of Plastic Surgery, Department of Surgery, United States. FAU - Hu, Han-Chung AU - Hu HC AD - Chang Gung University, Chang Gung Memorial Hospital, Division of Pulmonary Medicine, Department of Internal Medicine, Taiwan. FAU - Chang, Tommy Nai-Jen AU - Chang TN AD - Taiwan, and Chang Gung University, Chang Gung Memorial Hospital, Department of Plastic and Reconstructive Surgery, Taiwan. FAU - Chuang, David Chwei-Chin AU - Chuang DC AUID- ORCID: 0000-0002-6117-5600 AD - Taipei Medical University, Wan Fang Hospital, Division of Plastic and Reconstructive Surgery, Department of Surgery, Taiwan. FAU - Lu, Johnny Chuieng-Yi AU - Lu JC AD - Taiwan, and Chang Gung University, Chang Gung Memorial Hospital, Department of Plastic and Reconstructive Surgery, Taiwan. AD - Memorial Sloan Kettering Cancer Center, Division of Plastic Surgery, Department of Surgery, United States. LA - eng PT - Journal Article DEP - 20260529 PL - United States TA - J Reconstr Microsurg JT - Journal of reconstructive microsurgery JID - 8502670 SB - IM COIS- The authors declare that they have no conflict of interest. EDAT- 2026/05/30 00:32 MHDA- 2026/05/30 00:32 CRDT- 2026/05/29 19:14 PHST- 2026/05/30 00:32 [medline] PHST- 2026/05/30 00:32 [pubmed] PHST- 2026/05/29 19:14 [entrez] AID - 10.1055/a-2880-0545 [doi] PST - aheadofprint SO - J Reconstr Microsurg. 2026 May 29. doi: 10.1055/a-2880-0545. PMID- 42214131 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260611 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 149 DP - 2026 Sep TI - Orthorexia nervosa prevalence and associated factors in individuals attending a diet outpatient clinic: A cross-sectional study. PG - 113258 LID - S0899-9007(26)00166-8 [pii] LID - 10.1016/j.nut.2026.113258 [doi] AB - BACKGROUND: Orthorexia nervosa (ON) is characterized by an excessive preoccupation with consuming healthy foods, which may lead to dietary restrictions, psychological distress, and social isolation. Despite its increasing recognition, ON is not yet formally classified in the diagnostic and statistical manual of mental disorders (DSM), and its prevalence among individuals seeking dietary guidance remains underexplored. This study aims to evaluate the prevalence of orthorexic tendencies and their associated factors among individuals attending a diet outpatient clinic. METHODS: A cross-sectional study was conducted at the Yalova Governmental Hospital Outpatient Diet Polyclinic. A total of 265 participants were recruited using a convenience sampling method. Data were collected through a socio-demographic questionnaire and the ORTO-15 Scale, a widely used tool for assessing ON tendencies. Statistical analyses were performed using SPSS 22.0, with chi-square tests and ANOVA applied to examine relationships between ON and body mass index (BMI). A p-value <.05 was considered statistically significant. In addition, a multivariable logistic regression analysis was conducted to identify factors associated with orthorexic tendencies. RESULTS: The prevalence of orthorexic tendencies among participants was 17%, exceeding the rates reported in the general population. No significant relationship was found between BMI and ON tendencies (p = .27), supporting previous research suggesting that ON is more concerned with food quality than body image. In the multivariable logistic regression analysis, none of the examined variables were significantly associated with orthorexic tendencies. Participants relied primarily on mass media and dietitians for nutritional information, indicating potential influences on dietary behaviors. CONCLUSIONS: This study identified orthorexic tendencies in 17% of individuals attending a diet outpatient clinic, exceeding general population estimates. However, given the psychometric limitations of the ORTO-15, this figure should be interpreted cautiously. No significant sociodemographic or clinical predictors were identified. These findings suggest that orthorexic tendencies may be clinically relevant in dietary settings and highlight the need for validated assessment tools and further research. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Atabay, Fatma Ebru AU - Atabay FE AD - Yalova Governmental Hospital Diet Outpatient Clinic, Yalova, Turkey. FAU - Altin, Duygu AU - Altin D AD - Department of Psychology, University of Amsterdam, Amsterdam, the Netherlands. Electronic address: d.altin@uva.nl. LA - eng PT - Journal Article DEP - 20260502 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Adult MH - Prevalence MH - Male MH - Body Mass Index MH - Young Adult MH - Surveys and Questionnaires MH - *Feeding and Eating Disorders/epidemiology/psychology MH - *Feeding Behavior/psychology MH - Middle Aged MH - Adolescent MH - *Diet, Healthy/psychology MH - Logistic Models MH - *Diet/psychology MH - Ambulatory Care Facilities OTO - NOTNLM OT - Body mass index (BMI) OT - Dietary behavior OT - Eating disorders OT - Healthy eating obsession OT - ORTO-15 scale OT - Orthorexia nervosa COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/30 00:33 MHDA- 2026/06/12 00:38 CRDT- 2026/05/29 18:03 PHST- 2025/06/20 00:00 [received] PHST- 2026/04/20 00:00 [revised] PHST- 2026/04/23 00:00 [accepted] PHST- 2026/06/12 00:38 [medline] PHST- 2026/05/30 00:33 [pubmed] PHST- 2026/05/29 18:03 [entrez] AID - S0899-9007(26)00166-8 [pii] AID - 10.1016/j.nut.2026.113258 [doi] PST - ppublish SO - Nutrition. 2026 Sep;149:113258. doi: 10.1016/j.nut.2026.113258. Epub 2026 May 2. PMID- 42214087 OWN - NLM STAT- MEDLINE DCOM- 20261014 LR - 20261014 IS - 1545-9632 (Electronic) IS - 1545-9624 (Print) IS - 1545-9624 (Linking) VI - 23 IP - 9 DP - 2026 Sep TI - A customized system for whole-body vibration measurement. PG - 607-617 LID - 10.1080/15459624.2026.2659859 [doi] AB - This manuscript describes the technical components and performance of a custom whole-body vibration (WBV) instrumentation system designed for autonomous, prolonged field measurement. The study demonstrated the technical readiness of the system's accelerometers. The system integrates a Teensy 4.1 microcontroller, triaxial microelectromechanical system accelerometers, force sensing resistors, global positioning system module, and microSD data storage. The accelerometers were validated against reference accelerometers commonly used in field-based WBV measurement using a motion simulator programmed with complex vibration input profiles specified in ISO 7096:2020 Earth-Moving Machinery-Laboratory Evaluation of Operator Seat Vibration for testing operator seat vibration in earth moving machinery. In the time domain, accelerometers in the custom WBV instrumentation system exhibited /= 10 h of daily sedentary time had a higher risk of poor sleep quality (OR = 1.308, 95% CI: 1.169-1.465) than those with < 10 h. Those with poor mental health had a significantly elevated risk (OR = 7.434, 95% CI: 6.535-8.456) compared to those with good mental health. A multiplicative interaction was observed between daily sedentary time and mental health on adolescents' sleep quality (p < 0.05, OR = 0.791, 95% CI: 0.651-0.961), but no additive interaction (RERI = - 0.052, 95% CI: -4.033-3.930; AP = - 0.007, 95% CI : -0.526 - 0.512; S = 0.992, 95% CI : 0.549-1.794). Mental health levels moderated the relationship between daily sedentary time and sleep quality. CONCLUSIONS: Daily sedentary time and mental health were independently associated with sleep quality, and mental health moderated this relationship. These findings suggest that strategies targeting both factors may hold potential for improving adolescent sleep. CI - (c) 2026. The Author(s). FAU - Xiang, Weiwei AU - Xiang W AD - School of Public Health, Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. AD - Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Zheng, Lijuan AU - Zheng L AD - School of Public Health, Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. AD - Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Zhou, Chenghao AU - Zhou C AD - Department of dermatology, TaiHe Hospital, Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Liu, Xiang AU - Liu X AD - Health Management Center, Renmin Hospital, Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Dai, Li AU - Dai L AD - Dongfeng Stomatological Hospital, Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Min, Xinwen AU - Min X AD - Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Yang, Handong AU - Yang H AD - Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Chen, Jun AU - Chen J AD - Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Chen, Jishun AU - Chen J AD - Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Li, Dongfeng AU - Li D AD - Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. FAU - Xu, Hao AU - Xu H AD - Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. 18372660141@139.com. FAU - Wu, Wenwen AU - Wu W AD - School of Public Health, Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. wuwenwen108@126.com. AD - Sinopharm Dongfeng General Hospital (Hubei Clinical Research Center of Hypertension), Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. wuwenwen108@126.com. AD - Center of Health Administration and Development Studies, Hubei University of Medicine, Shiyan, Hubei Province, 442000, China. wuwenwen108@126.com. LA - eng PT - Journal Article DEP - 20260528 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - *Sedentary Behavior MH - Adolescent MH - Female MH - China/epidemiology MH - Cross-Sectional Studies MH - *Mental Health/statistics & numerical data MH - *Sleep Quality MH - Male PMC - PMC13397720 OTO - NOTNLM OT - Blood pressure OT - Chinese adolescents OT - Daily sedentary time OT - Mental health OT - Sleep quality COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the principles of the Declaration of Helsinki and was approved by the Humanities Research Ethics Committee of the Hubei University of Medicine (Approval No. 2023-RE-027). Permission to conduct the survey was obtained from each school administration. In addition, written informed consent was obtained from all participating students and their legal guardians prior to data collection. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/29 15:45 MHDA- 2026/07/24 06:35 PMCR- 2026/05/28 CRDT- 2026/05/29 00:07 PHST- 2025/10/26 00:00 [received] PHST- 2026/05/22 00:00 [accepted] PHST- 2026/07/24 06:35 [medline] PHST- 2026/05/29 15:45 [pubmed] PHST- 2026/05/29 00:07 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - 10.1186/s40359-026-04877-9 [pii] AID - 4877 [pii] AID - 10.1186/s40359-026-04877-9 [doi] PST - epublish SO - BMC Psychol. 2026 May 28;14(1):1102. doi: 10.1186/s40359-026-04877-9. PMID- 42210272 OWN - NLM STAT- MEDLINE DCOM- 20260805 LR - 20260910 IS - 1741-7015 (Electronic) IS - 1741-7015 (Linking) VI - 24 IP - 1 DP - 2026 May 28 TI - Machine learning and natural language processing for the identification of potential mental disorders among school-age children: a prospective birth cohort study. LID - 10.1186/s12916-026-04927-4 [doi] LID - 413 AB - BACKGROUND: Early identification of childhood mental health disorders is a critical public health objective. Existing screening approaches, largely dependent on observer reports, are resource-intensive and may overlook subtle internalized symptoms. The analysis of children's linguistic expression presents a scalable and potentially more objective alternative. This study evaluates whether combining natural language processing (NLP) of children's essays with conventional risk factors improves the detection of mental health difficulties in school-age populations, relative to models based on a single data source. METHODS: We conducted a prospective analysis using data from the UK-based National Child Development Study (NCDS), a national birth cohort initiated in 1958. Data from birth, age 7, and age 11 assessments were analyzed. The final sample included 8,981 children (4,428 [49.3%] female) who completed a creative writing essay at age 11 describing their imagined life at age 25. Predictors comprised traditional risk factors (perinatal, socioeconomic, and parental engagement variables) and linguistic features computationally extracted from the essays. The primary outcome was potential mental health disorder at age 11, defined as scoring above the 95th or 90th percentile on the teacher-completed Bristol Social Adjustment Guide (BSAG). The mother-completed Rutter A Scale was used for sensitivity analysis. Machine learning models incorporating various predictor combinations were developed, and their predictive performance was evaluated using area under the receiver operating characteristic (AUROC) values. RESULTS: Using BSAG 95th percentile threshold, models combining top five selected variables with essay features achieved significantly higher predictive capability (AUROC:0.77, 95%CI:0.71-0.83) compared to models using all variables (AUROC:0.70, 95%CI:0.63-0.76) or essay features alone (AUROC:0.67, 95%CI:0.60-0.74). At 90th percentile threshold, this integrated approach showed similar improvement (AUROC:0.81, 95%CI:0.78-0.85). Key predictors included gestational length, maternal parity, parental age, residential characteristics, parental engagement metrics, and children's body mass index. Sensitivity analyses using Rutter A Scale confirmed these findings. CONCLUSIONS: In this prospective birth cohort study, integrating NLP analysis of children's essays with a small set of key risk factors substantially improved the identification of potential mental health disorders. This integrated approach represents a potential paradigm for developing scalable, objective screening tools, but requires validation in contemporary, diverse pediatric populations before clinical consideration. CI - (c) 2026. The Author(s). FAU - Chen, Shanquan AU - Chen S AD - School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. shanquan.chen@hku.hk. FAU - Dang, Ting AU - Dang T AD - School of Computing and Information Systems, University of Melbourne, Melbourne, VIC, 3010, Australia. FAU - Qian, Mengjie AU - Qian M AD - Department of Engineering, University of Cambridge, Cambridge, CB2 1PZ, UK. FAU - Liang, Huizhi AU - Liang H AD - School of Computing, Newcastle University, Newcastle upon Tyne, UK. FAU - Bedada, Diribsa Tsegaye AU - Bedada DT AD - Department of Health and Rehabilitation Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 7505, South Africa. AD - Department of Statistics and Actuarial Science, University of Waterloo, Waterloo, Canada. FAU - Louw, Quinette Abegail AU - Louw QA AD - Department of Health and Rehabilitation Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, 7505, South Africa. FAU - Moore, Anna AU - Moore A AD - Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK. FAU - Cardinal, Rudolf N AU - Cardinal RN AD - Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK. AD - Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, CB21 5EF, UK. FAU - Ford, Tamsin J AU - Ford TJ AD - Department of Psychiatry, University of Cambridge, Cambridge, CB2 0SZ, UK. AD - Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, CB21 5EF, UK. FAU - Jiang, Fan AU - Jiang F AD - School of public health, Shandong ENT Hospital, Shandong University, Jinan, Shandong, China, 250012. Jiang.fan@sdu.edu.cn. LA - eng GR - NIHR203312/NIHR Cambridge Biomedical Research Centre/ GR - 72204143/National Natural Science Foundation of China/ GR - ZR2022QG081/Natural Science Foundation of Shandong Province of China/ GR - MR/Z504816/1/MRC_/Medical Research Council/United Kingdom PT - Journal Article DEP - 20260528 PL - England TA - BMC Med JT - BMC medicine JID - 101190723 SB - IM MH - Humans MH - *Natural Language Processing MH - Female MH - *Machine Learning MH - Prospective Studies MH - Child MH - *Mental Disorders/diagnosis MH - Birth Cohort MH - Male MH - United Kingdom MH - Risk Factors MH - Predictive Learning Models PMC - PMC13439860 OTO - NOTNLM OT - Children OT - Machine learning OT - Mental health screening OT - Natural language processing COIS- Declarations. Ethics approval and consent to participate: This study uses data from the National Child Development Study (NCDS), a nationally representative longitudinal cohort initiated in 1958. Informed consent was obtained for all data collections, with parental consent provided for assessments conducted during childhood, including the age-11 survey and essay-writing task. Formal ethical approval for NCDS follow-ups has been obtained from the UK NHS Multi-Centre Research Ethics Committee (MREC) for all surveys conducted since 2000. Earlier waves, including those in 1958, 1965, 1969, 1974, 1981, and 1991, were conducted prior to the establishment of formal ethics committees or the MREC system. Available documentation indicates that internal ethical review processes were in place for these early waves. For example, the Biomedical Survey and age-55 follow-up were approved by the NHS London-Central Research Ethics Committee (REC) in 2012 (Ref: 12/LO/2010). The current study is a secondary analysis of de-identified public data accessed via the UK Data Service (Study No. 5790). As such, it is exempt from further institutional ethical review, as it does not involve human participants or identifiable private information. Consent for publication: Not applicable. Competing interests: RNC consults for Campden Instruments Ltd; receives royalties from Cambridge University Press, Cambridge Enterprise, and Routledge; and is an unpaid non-executive director of Cambridge University Health Partners. TJF's research group receives funding for methodology consulting from Place2Be, a third sector organisation that provides mental health training and interventions to UK schools. SC and other authors declare no conflict of interest with this work. EDAT- 2026/05/29 15:44 MHDA- 2026/08/05 06:42 PMCR- 2026/05/28 CRDT- 2026/05/29 00:02 PHST- 2025/11/20 00:00 [received] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/08/05 06:42 [medline] PHST- 2026/05/29 15:44 [pubmed] PHST- 2026/05/29 00:02 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - 10.1186/s12916-026-04927-4 [pii] AID - 4927 [pii] AID - 10.1186/s12916-026-04927-4 [doi] PST - epublish SO - BMC Med. 2026 May 28;24(1):413. doi: 10.1186/s12916-026-04927-4. PMID- 42210252 OWN - NLM STAT- MEDLINE DCOM- 20260805 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 May 28 TI - Parents' physical literacy is associated with children's physical activity through parental support. LID - 10.1186/s12889-026-27914-z [doi] LID - 2277 AB - BACKGROUND: Physical activity provides multifaceted physical and mental health benefits for children; however, many children do not achieve the recommended levels. As children spend much of their time with their families, parental support is a key facilitator of physical activity engagement. Physical literacy is related to an individual's physical activity, which may, in turn, affect parental support and, consequently, children's activity levels. Nonetheless, knowledge of how parents' physical literacy relates to parental support and children's activities remains scarce. We aimed to examine the associations between parents' physical literacy, parental support, and children's physical activity. We hypothesized that parents' physical literacy is positively associated with their children's physical activity, directly and indirectly, through supportive behavior. METHODS: In this cross-sectional study, we analyzed data from 2,000 parents (mean age, 40.2 +/- 5.4 years) of children aged 4-9 years from the follow-up survey of the Japan Sports Agency Project for Promoting Physical Activity Habits from Early Childhood. Parents' physical literacy was assessed using the Physical Literacy for Life self-assessment tool, parental support was assessed using five validated items, and children's physical activity was assessed using two parent-reported questions. Structural equation modeling with bootstrapping and bias-corrected confidence intervals (5,000 samples) was used to examine the direct and indirect associations among these variables. RESULTS: Structural equation modeling demonstrated an acceptable model fit (comparative fit index = 0.980, goodness-of-fit index = 0.981, adjusted goodness-of-fit index = 0.968, root mean square error of approximation = 0.047). Parents' physical literacy was positively associated with both parental support (beta = 0.28, p < 0.01) and children's physical activity (beta = 0.09, p < 0.01). Parental support was also associated with children's physical activity (beta = 0.60, p < 0.01). CONCLUSIONS: Parents' physical literacy was positively associated with parental support and children's physical activity, suggesting a mediating role of parental support in this relationship. Enhancing parents' physical literacy may encourage supportive behaviors that contribute to children's physical activity through family-based approaches. CI - (c) 2026. The Author(s). FAU - Matsunaga, Misaki AU - Matsunaga M AD - Juntendo Administration for Sports, Health and Medical Sciences, Juntendo University, Tokyo, Japan. FAU - Matsui, Masahiro AU - Matsui M AD - Faculty of Health and Sports Science, Juntendo University, Chiba, Japan. AD - Department of Child Psychiatry, Yokohama City University Hospital, Kanagawa, Japan. FAU - Toyama, Kenta AU - Toyama K AD - Faculty of Health and Sports Science, Juntendo University, Chiba, Japan. FAU - Someya, Yuki AU - Someya Y AD - Juntendo Administration for Sports, Health and Medical Sciences, Juntendo University, Tokyo, Japan. AD - Faculty of Health and Sports Science, Juntendo University, Chiba, Japan. AD - Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. FAU - Kawata, Yujiro AU - Kawata Y AD - Faculty of Health and Sports Science, Juntendo University, Chiba, Japan. AD - Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. AD - Institute of Health and Sports Science & Medicine, Juntendo University, Chiba, Japan. FAU - Kito, Tomonori AU - Kito T AD - Faculty of Health and Sports Science, Juntendo University, Chiba, Japan. AD - Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. FAU - Nakamura, Emi AU - Nakamura E AD - Juntendo Administration for Sports, Health and Medical Sciences, Juntendo University, Tokyo, Japan. AD - Faculty of Health and Sports Science, Juntendo University, Chiba, Japan. AD - Department of Physical Therapy, Faculty of Health Science, Juntendo University, Tokyo, Japan. FAU - Shoji, Hiromichi AU - Shoji H AD - Juntendo Administration for Sports, Health and Medical Sciences, Juntendo University, Tokyo, Japan. AD - Department of Pediatrics, Faculty of Medicine, Juntendo University, Tokyo, Japan. FAU - Suzuki, Koya AU - Suzuki K AD - Juntendo Administration for Sports, Health and Medical Sciences, Juntendo University, Tokyo, Japan. ko-suzuki@juntendo.ac.jp. AD - Faculty of Health and Sports Science, Juntendo University, Chiba, Japan. ko-suzuki@juntendo.ac.jp. AD - Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. ko-suzuki@juntendo.ac.jp. AD - Institute of Health and Sports Science & Medicine, Juntendo University, Chiba, Japan. ko-suzuki@juntendo.ac.jp. LA - eng GR - JP25K24347/Japan Society for the Promotion of Science/ GR - JP25K14727/Japan Society for the Promotion of Science/ PT - Journal Article DEP - 20260528 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Child MH - Cross-Sectional Studies MH - *Parents/psychology MH - Female MH - Child, Preschool MH - Male MH - *Exercise/psychology MH - *Parent-Child Relations MH - Family Support MH - *Health Literacy/statistics & numerical data MH - Adult MH - Japan PMC - PMC13439896 OTO - NOTNLM OT - Parental Support OT - Parent-Child Relationship OT - Physical Activity Promotion OT - Physical Literacy OT - Structural Equation Modeling COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the principles of the Declaration of Helsinki. The study was a secondary analysis of data collected from the Japan Sports Agency Project for Promoting Physical Activity Habits from Early Childhood. All participants provided informed consent for the use of their data at the time of the original survey. The secondary analysis of the dataset was approved by the Research Ethics Committee of the Juntendo University School of Health and Sports Science and Graduate School of Health and Sports Science (approval no. 2024-69) with permission from the Japan Sports Agency. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/29 15:46 MHDA- 2026/08/05 06:41 PMCR- 2026/05/28 CRDT- 2026/05/29 00:01 PHST- 2026/01/09 00:00 [received] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/08/05 06:41 [medline] PHST- 2026/05/29 15:46 [pubmed] PHST- 2026/05/29 00:01 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - 10.1186/s12889-026-27914-z [pii] AID - 27914 [pii] AID - 10.1186/s12889-026-27914-z [doi] PST - epublish SO - BMC Public Health. 2026 May 28;26(1):2277. doi: 10.1186/s12889-026-27914-z. PMID- 42208609 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260925 IS - 1543-5474 (Electronic) IS - 1543-3080 (Linking) VI - 23 IP - 10 DP - 2026 Oct 1 TI - Parents' Interpretation of Physical Activity Recommendations for Preschool Children: A Qualitative Study of Everyday Family Practices and Contextual Influences. PG - 1417-1423 LID - 10.1123/jpah.2026-0112 [doi] AB - BACKGROUND: Early childhood physical activity is a core component of 24-hour movement behaviors and plays a critical role in children's health and development. Although global guidelines provide recommendations for preschool-aged children, less is known about how parents interpret and translate these recommendations into everyday family practices. This study aimed to explore parents' perceptions and experiences regarding physical activity recommendations for preschool children and how these are implemented within daily family contexts. METHODS: A qualitative descriptive phenomenological study was conducted with 17 parents of preschool children recruited from early childhood education settings in southern Chile. Semistructured interviews were audio recorded, transcribed verbatim, and analyzed using Colaizzi's method. Reporting followed the Consolidated Criteria for Reporting Qualitative Research (COREQ). Data were organized into themes and categories reflecting parental experiences and contextual influences on physical activity promotion. RESULTS: Three interrelated themes were identified: (1) meanings attributed to physical activity recommendations, (2) parental role and practices, and (3) contextual facilitators and barriers. Parents primarily conceptualized physical activity through play, coparticipation, and relational engagement rather than structured exercise. Awareness of formal recommendations was limited, with caregiving practices guided mainly by intuitive beliefs about child development. Environmental conditions, time constraints, and housing characteristics strongly influenced opportunities for movement. CONCLUSIONS: Parents do not implement physical activity recommendations as prescriptive guidelines but reinterpret them through relational and contextual practices. Physical activity promotion strategies for preschool children should emphasize family-based engagement and context-sensitive physical activity promotion approaches to enhance the relevance and feasibility of guideline implementation. FAU - Altamirano, Catalina AU - Altamirano C AUID- ORCID: 0009-0005-1212-8559 AD - School of Kinesiology, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile. FAU - Lorca, Paola AU - Lorca P AUID- ORCID: 0009-0008-0680-1577 AD - School of Kinesiology, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile. FAU - Barria, R Mauricio AU - Barria RM AUID- ORCID: 0000-0002-3764-5254 AD - Instituto de Ciencias del Movimiento y la Ocupacion Humana, Facultad de Medicina, Universidad Austral de Chile, Valdivia, Chile. LA - eng PT - Journal Article DEP - 20260527 PL - United States TA - J Phys Act Health JT - Journal of physical activity & health JID - 101189457 SB - IM MH - Humans MH - Child, Preschool MH - Male MH - Female MH - *Parents/psychology MH - Qualitative Research MH - Chile MH - *Exercise/psychology MH - Adult MH - Parent-Child Relations MH - Interviews as Topic MH - Parenting OTO - NOTNLM OT - child, preschool OT - health behavior OT - motor activity OT - parents OT - qualitative research EDAT- 2026/05/29 15:46 MHDA- 2026/09/25 17:32 CRDT- 2026/05/28 19:32 PHST- 2026/02/12 00:00 [received] PHST- 2026/03/21 00:00 [revised] PHST- 2026/04/19 00:00 [accepted] PHST- 2026/09/25 17:32 [medline] PHST- 2026/05/29 15:46 [pubmed] PHST- 2026/05/28 19:32 [entrez] AID - 10.1123/jpah.2026-0112 [doi] PST - epublish SO - J Phys Act Health. 2026 May 27;23(10):1417-1423. doi: 10.1123/jpah.2026-0112. Print 2026 Oct 1. PMID- 42207771 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 5 DP - 2026 TI - Physical activity and depressive symptoms among Chinese university students: Grit as a mediator. PG - e0350277 LID - 10.1371/journal.pone.0350277 [doi] LID - e0350277 AB - BACKGROUND: While physical activity is widely recognized for its protective role against depressive symptoms, the specific psychological mechanisms that explain this relationship, particularly among Chinese university students, require further exploration. The present study seeks to clarify whether grit as a hypothesized mediator explaining how physical activity is linked to depressive symptoms severity within this population. METHODS: In this cross-sectional investigation, 3,140 Chinese university students were recruited to complete an online survey. Assessments included demographic variables, physical activity levels, grit, and depressive symptoms, each measured with validated instruments. The hypothesized mediation pathway-wherein grit serves as the mediating variable-was tested via the PROCESS macro for SPSS, with bias-corrected bootstrapping (5,000 resamples) used to assess the indirect effect. RESULTS: Analyses demonstrated a significant negative association between physical activity and depressive symptoms. Crucially, grit was found to completely mediate this association. The indirect pathway through grit was statistically significant (ab = -0.013, 95% CI [-0.016, -0.010]), whereas the direct effect of physical activity was non-significant (c' = -0.002, p > 0.05, 95% CI [-0.011, 0.007]). CONCLUSIONS: These findings indicate that the beneficial effect of physical activity on depressive symptoms is primarily channeled through grit. Intervention strategies aimed at improving mental well-being in this population may be more effective if they combine physical activity promotion with grit-fostering components. CI - Copyright: (c) 2026 Chen, Zhang. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Chen, Yizhou AU - Chen Y AUID- ORCID: 0009-0007-8363-1340 AD - Department of Physical Education, Quzhou University, Quzhou, Zhejiang, China. FAU - Zhang, Jie AU - Zhang J AD - College of Physical Education, Anhui Normal University, Wuhu, Anhui, China. LA - eng PT - Journal Article DEP - 20260528 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Students/psychology MH - *Depression/psychology/epidemiology MH - Universities MH - Female MH - China/epidemiology MH - Young Adult MH - Male MH - *Exercise/psychology MH - Cross-Sectional Studies MH - Adult MH - Adolescent MH - Surveys and Questionnaires PMC - PMC13218493 COIS- The authors have declared that no competing interests exist. EDAT- 2026/05/29 15:44 MHDA- 2026/05/29 15:45 PMCR- 2026/05/28 CRDT- 2026/05/28 13:35 PHST- 2026/01/15 00:00 [received] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/05/29 15:45 [medline] PHST- 2026/05/29 15:44 [pubmed] PHST- 2026/05/28 13:35 [entrez] PHST- 2026/05/28 00:00 [pmc-release] AID - PONE-D-25-61526 [pii] AID - 10.1371/journal.pone.0350277 [doi] PST - epublish SO - PLoS One. 2026 May 28;21(5):e0350277. doi: 10.1371/journal.pone.0350277. eCollection 2026. PMID- 42207271 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260927 IS - 1432-198X (Electronic) IS - 0931-041X (Print) IS - 0931-041X (Linking) VI - 41 IP - 11 DP - 2026 Nov TI - Development and validation of a cuff size prediction model for pediatric blood pressure measurement outside the office. PG - 3923-3930 LID - 10.1007/s00467-026-07344-0 [doi] AB - BACKGROUND: Mid-arm circumference (AC) is typically measured in person to determine cuff size for ambulatory blood pressure monitoring (ABPM). Our objective was to develop a model to predict cuff size using electronic health record (EHR) data to enable virtual ABPM programs. METHODS: We developed a prediction model for youth 3-21 years in the National Health and Nutrition Examination Survey. Using linear regression, we considered piecewise and polynomial effects of age, sex, height, and weight as predictors of AC. We selected the model with the lowest bootstrapped root-mean-square error (RMSE) and predicted residual error sum of squares with leave-one-out cross-validation. We validated the model in pediatric hypertension clinics at an academic medical center. RESULTS: Based on 34,517 youth in the derivation cohort (median 12 years (25th, 75th percentiles: 7, 16), 49.0% female, 16.6% obesity), the final model included age, age(2), sex, height, weight, weight(2), weight(3), and all possible interactions between age and height and between age and weight (adjusted R(2), 0.97; RMSE, 1.20). In the external validation cohort of 107 youth (median 14 years (25th, 75th percentiles: 10, 17), 35.5% female, 61.7% obesity), observed and predicted AC were highly concordant (⍴(c), 0.94) with mean bias of -0.5 cm (95% limits of agreement, -5.2; 4.1). Overall agreement for the correct cuff size was 87.5% in the derivation cohort (weighted kappa, 0.92) and 83.2% in the validation cohort (weighted kappa, 0.90). CONCLUSIONS: We found substantial agreement between observed and predicted AC using basic EHR data. This model may facilitate ABPM when in-person visits are not feasible. CI - (c) 2026. The Author(s), under exclusive licence to International Pediatric Nephrology Association. FAU - Nugent, James T AU - Nugent JT AUID- ORCID: 0000-0001-9707-5102 AD - Section of Pediatric Nephrology, Department of Pediatrics, Yale School of Medicine, 60 Temple Street, Suite 6C, New Haven, CT, 06510, USA. james.nugent@yale.edu. AD - Section of General Pediatrics, Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA. james.nugent@yale.edu. AD - Clinical and Translational Research Accelerator, Department of Medicine, Yale School of Medicine, New Haven, CT, USA. james.nugent@yale.edu. FAU - Cueto, Victoria AU - Cueto V AD - Section of General Pediatrics, Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA. FAU - Medvecky, Hugh AU - Medvecky H AD - Yale Center for Clinical Investigation, Yale School of Medicine, New Haven, CT, USA. FAU - Harper, Morgan AU - Harper M AD - Section of General Pediatrics, Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA. FAU - Batti, Varshini AU - Batti V AD - Clinical and Translational Research Accelerator, Department of Medicine, Yale School of Medicine, New Haven, CT, USA. FAU - Greenberg, Jason H AU - Greenberg JH AD - Section of Pediatric Nephrology, Department of Pediatrics, Yale School of Medicine, 60 Temple Street, Suite 6C, New Haven, CT, 06510, USA. AD - Clinical and Translational Research Accelerator, Department of Medicine, Yale School of Medicine, New Haven, CT, USA. FAU - Shabanova, Veronika AU - Shabanova V AD - Section of General Pediatrics, Department of Pediatrics, Yale School of Medicine, New Haven, CT, USA. AD - Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA. LA - eng GR - K23 HL177261/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20260528 PL - Germany TA - Pediatr Nephrol JT - Pediatric nephrology (Berlin, Germany) JID - 8708728 SB - IM MH - Humans MH - Female MH - Adolescent MH - Child MH - *Blood Pressure Monitoring, Ambulatory/instrumentation/methods MH - Child, Preschool MH - Male MH - *Hypertension/diagnosis MH - Young Adult MH - Nutrition Surveys MH - Arm/anatomy & histology MH - Electronic Health Records/statistics & numerical data MH - Blood Pressure MH - Prediction Algorithms MH - Reproducibility of Results PMC - PMC13488455 MID - NIHMS2183132 OTO - NOTNLM OT - Ambulatory blood pressure monitoring OT - Arm circumference OT - Blood pressure OT - Cuff size OT - Hypertension OT - Pediatrics COIS- Declarations. Ethics approval: The study was deemed exempt by the Yale University IRB (HIC #2000033952) because the study was conducted retrospectively from medical record review. Competing interests: The authors declare no competing interests. Disclaimer: The content is solely the responsibility of the authors and does not necessarily represent the official views of the AHA or NIH. EDAT- 2026/05/28 12:34 MHDA- 2026/09/25 05:31 PMCR- 2026/08/20 CRDT- 2026/05/28 11:14 PHST- 2026/01/17 00:00 [received] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/04/21 00:00 [revised] PHST- 2026/09/25 05:31 [medline] PHST- 2026/05/28 12:34 [pubmed] PHST- 2026/05/28 11:14 [entrez] PHST- 2026/08/20 00:00 [pmc-release] AID - 10.1007/s00467-026-07344-0 [pii] AID - 10.1007/s00467-026-07344-0 [doi] PST - ppublish SO - Pediatr Nephrol. 2026 Nov;41(11):3923-3930. doi: 10.1007/s00467-026-07344-0. Epub 2026 May 28. PMID- 42207172 OWN - NLM STAT- MEDLINE DCOM- 20260528 LR - 20260813 IS - 2190-6009 (Electronic) IS - 2190-5991 (Print) IS - 2190-5991 (Linking) VI - 16 IP - 5 DP - 2025 Oct TI - Handgrip Strength Thresholds to Detect Cardiometabolic Risk in Youth: Cross-Sectional Study and Meta-Analysis. PG - e70091 LID - 10.1002/jcsm.70091 [doi] LID - e70091 AB - BACKGROUND: Muscular fitness, particularly handgrip strength, is increasingly recognized as a robust marker of cardiometabolic risk (CMR) in children and adolescents. However, evidence-based diagnostic thresholds for identifying at-risk individuals remain scarce, particularly in children. This study aimed to (1) establish sex-specific diagnostic thresholds for handgrip strength normalized to body weight to identify elevated CMR in children aged 8-11 years, and (2) synthesize existing evidence through a systematic review and meta-analysis across pediatric age groups, integrating the new data with existing evidence. METHODS: We analyzed cross-sectional data from 1124 Spanish children (49.7% girls) aged 8-11 years participating in the MOVI-2 study. Normalized handgrip strength was associated with a CMR index composed of waist circumference, triglyceride-to-HDL ratio, mean arterial pressure and fasting insulin. Diagnostic accuracy was assessed using receiver operating characteristic curves and optimized with the Youden Index. Results from the MOVI-2 study and other diagnostic accuracy studies were combined in a meta-analysis for identifying the optimal threshold for normalized handgrip strength to identify elevated CMR in youth. RESULTS: In the MOVI-2 study, thresholds were 0.38 for boys and 0.34 for girls, with area under the curve (AUC) of 0.77 (95% CI: 0.73-0.81) and 0.75 (95% CI: 0.70-0.79), respectively. The systematic review and meta-analysis followed PRISMA-DTA guidelines and included nine additional studies (n = 10 588). Meta-analytic thresholds for normalized handgrip strength were 0.30 for girls and 0.39 for boys in childhood (6-12 years), and 0.36 for girls and 0.42 for boys in adolescence (13-18 years), with the highest diagnostic accuracy observed in adolescent girls (AUC = 0.80, 95% CI: 0.77-0.83; Youden Index = 0.60). Children showed greater heterogeneity, particularly in specificity. CONCLUSIONS: Despite certain limitations, our findings provide clinically relevant, sex- and age-specific thresholds for normalized handgrip strength to identify elevated CMR in youth. These thresholds may serve as a valuable starting point for CMR screening in both boys and girls. CI - (c) 2025 The Author(s). Journal of Cachexia, Sarcopenia and Muscle published by Wiley Periodicals LLC. FAU - Garcia-Hermoso, Antonio AU - Garcia-Hermoso A AUID- ORCID: 0000-0002-1397-7182 AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona, Spain. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AD - Faculty of Education and Social Sciences, Universidad Andres Bello, Vina del Mar, Chile. AD - School of Medicine, Universidad Espiritu Santo (UEES), Samborondon, Ecuador. FAU - Hormazabal-Aguayo, Ignacio AU - Hormazabal-Aguayo I AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona, Spain. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de La Serena, La Serena, Chile. FAU - Munoz-Pardeza, Jacinto AU - Munoz-Pardeza J AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona, Spain. FAU - Martinez-Vizcaino, Vicente AU - Martinez-Vizcaino V AD - Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain. AD - Universidad Autonoma de Chile, Facultad de Ciencias de la Salud, Talca, Chile. FAU - Hurtado-Almonacid, Juan AU - Hurtado-Almonacid J AD - eFidac Research Group, School of Physical Education, Pontificia Universidad Catolica de Valparaiso, Chile. FAU - Ezzatvar, Yasmin AU - Ezzatvar Y AD - Lifestyle factors with impact on Ageing and overall Health (LAH) Research Group, Department of Nursing, University of Valencia, Valencia, Spain. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno, Chile. LA - eng GR - PII1I09-0259-9898/Ministry of Education and Science-Junta de Comunidades de Castilla-La Mancha/ GR - POII10-0208-5325/Ministry of Education and Science-Junta de Comunidades de Castilla-La Mancha/ GR - FIS PI081297/Ministry of Health/ GR - RD06/0018/0038/Research Network on Preventative Activities and Health Promotion/ GR - FEDER (Fondo Europeo de Desarrollo Regional)/ PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Systematic Review PL - Germany TA - J Cachexia Sarcopenia Muscle JT - Journal of cachexia, sarcopenia and muscle JID - 101552883 SB - IM MH - Child MH - Female MH - Humans MH - Male MH - *Cardiometabolic Risk Factors MH - *Cardiovascular Diseases/diagnosis/epidemiology MH - Cross-Sectional Studies MH - *Hand Strength/physiology MH - ROC Curve PMC - PMC12536247 OTO - NOTNLM OT - cut-off OT - grip strength OT - metabolic syndrome OT - receiver operating characteristic curves COIS- The authors declare no conflicts of interest. EDAT- 2026/05/28 12:33 MHDA- 2026/05/28 12:34 PMCR- 2025/10/20 CRDT- 2026/05/28 10:54 PHST- 2025/07/25 00:00 [revised] PHST- 2025/06/13 00:00 [received] PHST- 2025/08/19 00:00 [accepted] PHST- 2026/05/28 12:34 [medline] PHST- 2026/05/28 12:33 [pubmed] PHST- 2026/05/28 10:54 [entrez] PHST- 2025/10/20 00:00 [pmc-release] AID - JCSM70091 [pii] AID - 10.1002/jcsm.70091 [doi] PST - ppublish SO - J Cachexia Sarcopenia Muscle. 2025 Oct;16(5):e70091. doi: 10.1002/jcsm.70091. PMID- 42206997 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260825 IS - 1365-3016 (Electronic) IS - 0269-5022 (Print) IS - 0269-5022 (Linking) VI - 40 IP - 4 DP - 2026 May TI - Influence of Gestational Age Measurement Technique on the Associations Between Maternal Characteristics and Birth Outcomes. PG - 465-470 LID - 10.1111/ppe.70135 [doi] AB - BACKGROUND: Associations of factors of interest with preterm birth and small for gestational age (SGA) may be impacted by the technique used to measure gestational age at birth. OBJECTIVE: To compare the associations of several factors with preterm birth and SGA when gestational age was measured with three different techniques. METHODS: Among participants with a live birth in the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial, this study used three methods to estimate gestational age: 1) prospective fertility monitor ovulation, 2) prospective LMP, and 3) early ultrasound. The study assigned the outcomes of preterm birth and SGA by each method among participants with complete gestational age information (N = 392). The study reported unadjusted prevalence differences (PDs) and 95% confidence intervals (CIs) for preterm birth and SGA, by each method, with two commonly measured maternal characteristics: age >/= 35 years (versus < 35) and body mass index >/= 25 kg/m(2) (versus < 25), and with aspirin treatment (versus placebo). RESULTS: For all but one characteristic-outcome pair examined, unadjusted PDs were similar, within 3 percentage points, for all gestational age measurement techniques. The largest discrepancy among the PDs was in the association of age >/= 35 years with preterm birth: PD = 6% (95% CI: -6, 17) when defined by ovulation, 1% (95% CI: -10, 11) by ultrasound, and 2% (95% CI: -8, 11) by LMP. Precision of the PDs, as assessed by their confidence limit differences, did not identify a consistently more precise gestational age measurement technique. CONCLUSIONS: Even when gestational age was measured prospectively and early in pregnancy, small differences in the classification of preterm birth and SGA were found. These differences have the potential to bias the association of maternal characteristics with these outcomes. This should be considered by researchers, particularly in populations where the gestational age assignment technique is unknown. CI - (c) 2026 John Wiley & Sons Ltd. This article has been contributed to by U.S. Government employees and their work is in the public domain in the USA. FAU - Doss, Ginna L AU - Doss GL AUID- ORCID: 0000-0001-5795-9763 AD - Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), North Carolina, USA. AD - Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, North Carolina, USA. FAU - Daniels, Julie L AU - Daniels JL AD - Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, North Carolina, USA. FAU - Mumford, Sunni L AU - Mumford SL AUID- ORCID: 0000-0003-0133-3176 AD - Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. FAU - Poole, Charles AU - Poole C AD - Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, North Carolina, USA. FAU - Steiner, Anne Z AU - Steiner AZ AD - Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, North Carolina, USA. FAU - Schisterman, Enrique F AU - Schisterman EF AUID- ORCID: 0000-0003-3757-641X AD - Department of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. FAU - Silver, Robert M AU - Silver RM AD - Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, Utah, USA. FAU - Jukic, Anne Marie Z AU - Jukic AMZ AD - Epidemiology Branch, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), North Carolina, USA. LA - eng GR - HHSN26700603426/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ GR - NH/NIH HHS/United States GR - Z01ES1033333/ES/NIEHS NIH HHS/United States GR - HHSN26700603424/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ GR - ZIA ES103333/ImNIH/Intramural NIH HHS/United States GR - Intramural Research Program/ GR - HHSN267200603423/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ GR - University of North Carolina/ PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Paediatr Perinat Epidemiol JT - Paediatric and perinatal epidemiology JID - 8709766 RN - R16CO5Y76E (Aspirin) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Gestational Age MH - *Infant, Small for Gestational Age MH - *Premature Birth/epidemiology MH - Adult MH - Infant, Newborn MH - Aspirin/therapeutic use MH - Pregnancy Outcome MH - Maternal Age MH - Ultrasonography, Prenatal MH - Body Mass Index MH - Prospective Studies PMC - PMC13220909 MID - NIHMS2156473 OTO - NOTNLM OT - SGA OT - gestational age OT - measurement error OT - outcome misclassification OT - preterm COIS- The authors declare no conflicts of interest. EDAT- 2026/05/28 12:34 MHDA- 2026/05/28 12:35 PMCR- 2026/05/29 CRDT- 2026/05/28 10:03 PHST- 2026/03/02 00:00 [revised] PHST- 2025/07/29 00:00 [received] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/05/28 12:35 [medline] PHST- 2026/05/28 12:34 [pubmed] PHST- 2026/05/28 10:03 [entrez] PHST- 2026/05/29 00:00 [pmc-release] AID - 10.1111/ppe.70135 [doi] PST - ppublish SO - Paediatr Perinat Epidemiol. 2026 May;40(4):465-470. doi: 10.1111/ppe.70135. PMID- 42206090 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260528 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Athlete-focused eating disorder programming in higher levels of care: feasibility and clinical outcomes from a naturalistic setting. PG - 1734726 LID - 10.3389/fnut.2026.1734726 [doi] LID - 1734726 AB - Eating disorders (EDs) are a significant public health concern associated with psychiatric, physical, and functional impairments. Athletes experience elevated ED prevalence compared to non-athletes, with rates up to 19% in men and 45% in women. Among athletes, EDs present additional concerns including increased injury risk, impaired performance, prolonged illness, and potential premature athletic career termination. Dysfunctional exercise-a maladaptive pattern characterized by rigid rules, guilt, compulsivity, and inability to stop despite harm-is common in this population and linked to poorer outcomes. Despite increasing recognition of these risks, few studies have systematically evaluated athlete-focused interventions in higher levels of care. This study examined the feasibility and preliminary effectiveness of specialized athlete programming within partial hospitalization and intensive outpatient ED treatment programs. Participants included 182 adolescent and adult patients who self-identified as athletes and attended at least four athlete-focused therapy groups. Outcomes included dysfunctional exercise symptoms (EPSI), ED symptoms (EDE-Q), ED-related impairment (CIA), depression (PHQ-9), and anxiety (STAI). Linear mixed-effects models evaluated changes across admission, mid-treatment, discharge, and 6- and 12-month follow-ups. Pairwise comparisons of estimated marginal means were conducted using Tukey-adjusted contrasts to identify significant decreases between specific time points. Significant decreases were observed in dysfunctional exercise, ED symptoms, ED-related impairment, depression, and anxiety. The steepest improvements occurred between admission and mid-treatment for all outcomes except anxiety, which remained stable at first and declined sharply by discharge; all outcomes showed stabilization through 12-month follow-up. Findings provide preliminary empirical support for the feasibility and clinical utility of integrating athlete-focused programming into higher-level ED care, highlighting the importance of addressing the unique challenges and treatment needs of athletes. CI - Copyright (c) 2026 Dunbar, Palermo, Abber, Anderson, Felonis, Karam Jones, Bohrer, Wierenga, Rockwell and Claudat. FAU - Dunbar, Eva-Molly Petitto AU - Dunbar EP AD - Department of Psychiatry, Eating Disorder Treatment and Research Program, University of California San Diego, San Diego, CA, United States. FAU - Palermo, Madeline AU - Palermo M AD - Department of Pediatrics, Rady Children's Hospital, University of California San Diego School of Medicine, San Diego, CA, United States. FAU - Abber, Sophie R AU - Abber SR AD - Department of Psychiatry, Eating Disorder Treatment and Research Program, University of California San Diego, San Diego, CA, United States. FAU - Anderson, Leslie K AU - Anderson LK AD - Department of Psychiatry, Eating Disorder Treatment and Research Program, University of California San Diego, San Diego, CA, United States. FAU - Felonis, Christina R AU - Felonis CR AD - Department of Psychiatry, Eating Disorder Treatment and Research Program, University of California San Diego, San Diego, CA, United States. FAU - Karam Jones, Anna M AU - Karam Jones AM AD - Department of Psychiatry, Eating Disorder Treatment and Research Program, University of California San Diego, San Diego, CA, United States. FAU - Bohrer, Brittany K AU - Bohrer BK AD - Department of Psychiatry, Eating Disorder Treatment and Research Program, University of California San Diego, San Diego, CA, United States. FAU - Wierenga, Christina E AU - Wierenga CE AD - Department of Psychiatry, Eating Disorder Treatment and Research Program, University of California San Diego, San Diego, CA, United States. FAU - Rockwell, Roxanne E AU - Rockwell RE AD - Department of Psychiatry, Eating Disorder Treatment and Research Program, University of California San Diego, San Diego, CA, United States. FAU - Claudat, Kimberly AU - Claudat K AD - Department of Psychiatry, Eating Disorder Treatment and Research Program, University of California San Diego, San Diego, CA, United States. LA - eng PT - Journal Article DEP - 20260512 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13201481 OTO - NOTNLM OT - athletes OT - dysfunctional exercise OT - eating disorders OT - higher level of care OT - treatment outcomes COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/28 06:34 MHDA- 2026/05/28 06:35 PMCR- 2026/05/12 CRDT- 2026/05/28 04:43 PHST- 2025/10/29 00:00 [received] PHST- 2026/03/13 00:00 [revised] PHST- 2026/04/03 00:00 [accepted] PHST- 2026/05/28 06:35 [medline] PHST- 2026/05/28 06:34 [pubmed] PHST- 2026/05/28 04:43 [entrez] PHST- 2026/05/12 00:00 [pmc-release] AID - 10.3389/fnut.2026.1734726 [doi] PST - epublish SO - Front Nutr. 2026 May 12;13:1734726. doi: 10.3389/fnut.2026.1734726. eCollection 2026. PMID- 42206075 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260528 LR - 20260813 IS - 2673-253X (Electronic) IS - 2673-253X (Linking) VI - 8 DP - 2026 TI - Feasibility testing of a home-based exercise intervention in children with cerebral palsy who are ambulant-a study protocol of the HOME-EX study. PG - 1811789 LID - 10.3389/fdgth.2026.1811789 [doi] LID - 1811789 AB - Children gain increased health and well-being by participating in physical activity. Children with cerebral palsy who are ambulatory (CP-A) are known to be less physically active than children without physical disabilities, making them an important group of children to support in becoming more physically active. Assistive technologies, such as eHealth, may support physical exercise in children with CP-A. The overall aim of this study protocol will be to describe the procedures of the HOME-EX feasibility study to develop, feasibility test, and map the conditions for future implementation of a home-based exercise intervention using an eHealth solution in children with CP-A. METHODS: The HOME-EX feasibility study will use a mixed methods approach with an adapted participatory design. The study is informed by "The behaviour change wheel" framework to support health related behavioural changes. The development and the feasibility testing will follow three phases: 1) development; 2) refinement; and 3) finalising, where the children will perform two six-week periods of home-based exercises using an eHealth solution with eight weeks of washout in-between. Ten children with CP-A and ten children without disabilities, aged 10-16 years, living in the southern regions of Sweden will be recruited. The feasibility of the eHealth solution, the home-based exercise intervention, and the exercise testing will be assessed throughout the study. Field notes, questioners, data from the eHealth solution and semi-structured interviews will be used to collect data. DISCUSSION: Findings from the HOME-EX study have the potential to increase knowledge about the development and feasibility of a home-based exercise intervention, supported by the eHealth solution, to promote exercise in children with CP-A. CLINICAL TRAILS REGISTRATION: https://clinicaltrials.gov/expert-search?term=NCT07025694, identifier NCT07025694. CI - (c) 2026 Jakobsson, Lauruschkus, Johnsson, Andersson, Hansson, Holmberg and Tornberg. FAU - Jakobsson, Trille AU - Jakobsson T AD - Department of Health Sciences, Lund University, Lund, Sweden. FAU - Lauruschkus, Katarina AU - Lauruschkus K AD - Department of Health Sciences, Lund University, Lund, Sweden. AD - Department of Nursing and Integrated Health, Kristianstad University, Kristianstad, Sweden. FAU - Johnsson, Bjorn A AU - Johnsson BA AD - Department of Health Sciences, Lund University, Lund, Sweden. AD - Itacih, Lund, Sweden. FAU - Andersson, Asa AU - Andersson A AD - Department of Environmental- and Biosciences, FIH, Halmstad University, Halmstad, Sweden. FAU - Hansson, Ola AU - Hansson O AD - Department of Clinical Sciences, Malmo, Lund University, Malmo, Sweden. FAU - Holmberg, Robert AU - Holmberg R AD - Department of Psychology, Lund University, Lund, Sweden. FAU - Tornberg, Asa B AU - Tornberg AB AD - Department of Health Sciences, Lund University, Lund, Sweden. LA - eng SI - ClinicalTrials.gov/NCT07025694 PT - Journal Article DEP - 20260512 PL - Switzerland TA - Front Digit Health JT - Frontiers in digital health JID - 101771889 PMC - PMC13202785 OTO - NOTNLM OT - cerebral palsy OT - children OT - eHealth OT - exercise intervention OT - mixed methods design OT - participatory approach COIS- Author BJ was employed by company Itacih. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/28 06:31 MHDA- 2026/05/28 06:32 PMCR- 2026/05/12 CRDT- 2026/05/28 04:43 PHST- 2026/02/15 00:00 [received] PHST- 2026/04/01 00:00 [revised] PHST- 2026/04/06 00:00 [accepted] PHST- 2026/05/28 06:32 [medline] PHST- 2026/05/28 06:31 [pubmed] PHST- 2026/05/28 04:43 [entrez] PHST- 2026/05/12 00:00 [pmc-release] AID - 10.3389/fdgth.2026.1811789 [doi] PST - epublish SO - Front Digit Health. 2026 May 12;8:1811789. doi: 10.3389/fdgth.2026.1811789. eCollection 2026. PMID- 42205995 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260528 LR - 20260813 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Comparative efficacy of non-pharmacological therapies in adolescents with subthreshold depression: a systematic review and network meta-analysis. PG - 1799128 LID - 10.3389/fpsyt.2026.1799128 [doi] LID - 1799128 AB - BACKGROUND: Subthreshold depression (SD) is highly prevalent in adolescents and young adults aged 11-25 years, leading to impaired psychosocial functioning and a high risk of progression to major depressive disorder (MDD). Non-pharmacological therapies are the mainstay of intervention for adolescent SD, yet the comparative efficacy of different interventions remains unclear. This study aimed to compare the relative effectiveness of various non-pharmacological interventions for adolescent SD via network meta-analysis (NMA). METHODS: We initially retrieved 5,297 records from six databases (PubMed, Embase, Web of Science, Cochrane, PsycINFO, CINAHL) for randomized controlled trials (RCTs) of non-pharmacological interventions for SD in individuals aged 11-25 years who did not meet the DSM-IV/ICD-10 diagnostic criteria for MDD or depressive episode. The control groups received waitlist control or usual care, and the primary outcome was depressive symptoms assessed by validated scales (BDI-II, CES-D, CDI, HAMD). Two reviewers independently conducted study selection, data extraction and risk of bias assessment (RoB 2.0). Heterogeneity was analyzed using the I(2) statistic; NMA was performed under a Bayesian framework with consistency assessment, and the CINeMA tool was used to grade the certainty of evidence. This study was registered in PROSPERO (CRD42023456264) and reported in accordance with the PRISMA 2020 statement. RESULTS: A total of 30 RCTs involving 3,471 participants were included. Traditional meta-analysis showed that non-pharmacological interventions significantly improved depressive symptoms in adolescents with SD (pooled SMD = -0.93, 95% CI: -1.20 to -0.66, P < 0.0001), with high heterogeneity across studies (I(2) = 92%) driven by intervention type, delivery mode, intervention duration and participant age. NMA results indicated that behavioral activation (BA) was the most effective intervention (SMD = -3.45, 95% CI: -4.89 to -2.02), followed by physical exercise intervention (PEI) (SMD = -1.34, 95% CI: -2.68 to -0.03) and light therapy (LT) (SMD = -1.24, 95% CI: -2.17 to -0.31). No significant overall inconsistency was detected in the study (chi(2)=6.72, df=9, P = 0.651). CONCLUSIONS: Non-pharmacological interventions are effective for adolescents with SD, and BA is recommended as the first-line clinical option. Clinical selection of interventions should take into account individual patient characteristics and intervention features. This study has several limitations, including high heterogeneity across studies, single-study evidence for some interventions (e.g., LT, PEI), a broad age range of participants and the lack of long-term follow-up data. Further large-scale, multi-center RCTs are needed to validate these findings. CI - Copyright (c) 2026 Ji, Wang, Wang, Zhou, Lou, Su, Gao, Jiang, Qiu and Luo. FAU - Ji, Qipei AU - Ji Q AD - Department of Rehabilitation Medicine, The People's Hospital of Leshan, Leshan, China. FAU - Wang, Zhenbo AU - Wang Z AD - Department of Rehabilitation Medicine, The People's Hospital of Leshan, Leshan, China. FAU - Wang, Xiaobo AU - Wang X AD - Department of Rehabilitation Medicine, The People's Hospital of Leshan, Leshan, China. FAU - Zhou, Ling AU - Zhou L AD - Department of Rehabilitation Medicine, The People's Hospital of Leshan, Leshan, China. FAU - Lou, Zhenkui AU - Lou Z AD - Department of Rehabilitation Medicine, The People's Hospital of Leshan, Leshan, China. FAU - Su, Meiling AU - Su M AD - Department of Rehabilitation Medicine, The People's Hospital of Leshan, Leshan, China. FAU - Gao, Xin AU - Gao X AD - Department of Rehabilitation Medicine, The People's Hospital of Leshan, Leshan, China. FAU - Jiang, Shufang AU - Jiang S AD - Department of Rehabilitation Medicine, The People's Hospital of Leshan, Leshan, China. FAU - Qiu, Hongfei AU - Qiu H AD - Department of Rehabilitation Medicine, The People's Hospital of Leshan, Leshan, China. FAU - Luo, Zhongchun AU - Luo Z AD - Department of Rehabilitation Medicine, The People's Hospital of Leshan, Leshan, China. LA - eng PT - Journal Article PT - Review DEP - 20260512 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13202787 OTO - NOTNLM OT - adolescents OT - network meta-analysis OT - non-pharmacological therapies OT - subthreshold depression OT - systematic review COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/28 06:31 MHDA- 2026/05/28 06:32 PMCR- 2026/05/12 CRDT- 2026/05/28 04:43 PHST- 2026/01/29 00:00 [received] PHST- 2026/03/31 00:00 [revised] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/05/28 06:32 [medline] PHST- 2026/05/28 06:31 [pubmed] PHST- 2026/05/28 04:43 [entrez] PHST- 2026/05/12 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1799128 [doi] PST - epublish SO - Front Psychiatry. 2026 May 12;17:1799128. doi: 10.3389/fpsyt.2026.1799128. eCollection 2026. PMID- 42205725 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260528 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - A decade-long real-world cohort (2016-2025): development of an individualized risk-stratification nomogram and evaluation of clinical utility for recurrent respiratory tract infections in children. PG - 1806366 LID - 10.3389/fped.2026.1806366 [doi] LID - 1806366 AB - BACKGROUND: Recurrent respiratory tract infections (RRTIs) are common in children and are associated with substantial healthcare costs and reduced quality of life. A practical tool for individualized risk assessment may facilitate the early identification of high-risk children and support targeted prevention. METHODS: In this 10-year real-world cohort study (2016-2025), eligible children were screened and followed according to predefined criteria. After exclusions, 6,026 children were included, of whom 1,227 (20.4%) developed RRTIs. The cohort was randomly divided into a training set (n = 4,219; events = 859) and a testing set (n = 1,807; events = 368). Multivariable logistic regression was used in the training set to identify independent predictors and develop a customized nomogram. Bootstrap resampling was used for internal validation, and model performance was assessed in terms of discrimination, calibration, and clinical utility using decision-curve analysis. RESULTS: Multivariable analysis identified history of allergy (OR 5.187), history of asthma (OR 2.522), lower vitamin A level (OR 0.458 per 0.1 mg/L increase), lower vitamin D level (OR 0.556 per 10 ng/mL increase), lower birth weight (OR 0.283 per kg increase), passive smoking exposure (OR 2.061), and lower hemoglobin level (OR 0.425 per 10 g/L increase) as independent predictors of RRTI (all P < 0.001). The nomogram demonstrated good discrimination and calibration in both the training and testing sets. Decision-curve analysis supported its potential clinical utility by showing a favorable net benefit across clinically relevant threshold probabilities. Risk stratification based on predicted-probability cutoffs further separated children into low-, intermediate-, and high-risk groups with clearly different observed event rates. CONCLUSION: We developed and validated a nomogram based on routinely available clinical history and nutritional indicators to predict individualized RRTI risk in children. This tool demonstrated robust predictive performance and may support early risk stratification and preventive decision-making in pediatric practice. CI - (c) 2026 Cai, Li and Wang. FAU - Cai, Hehua AU - Cai H AD - Department of Pediatrics, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China. FAU - Li, Juan AU - Li J AD - Department of Pediatrics, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China. FAU - Wang, Hui AU - Wang H AD - Department of Pediatrics, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China. LA - eng PT - Journal Article DEP - 20260512 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13201507 OTO - NOTNLM OT - children OT - clinical utility OT - logistic regression OT - nomogram OT - prediction model OT - recurrent respiratory tract infections OT - risk stratification COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/28 06:32 MHDA- 2026/05/28 06:33 PMCR- 2026/05/12 CRDT- 2026/05/28 04:40 PHST- 2026/02/07 00:00 [received] PHST- 2026/03/21 00:00 [revised] PHST- 2026/04/14 00:00 [accepted] PHST- 2026/05/28 06:33 [medline] PHST- 2026/05/28 06:32 [pubmed] PHST- 2026/05/28 04:40 [entrez] PHST- 2026/05/12 00:00 [pmc-release] AID - 10.3389/fped.2026.1806366 [doi] PST - epublish SO - Front Pediatr. 2026 May 12;14:1806366. doi: 10.3389/fped.2026.1806366. eCollection 2026. PMID- 42205619 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260528 LR - 20260813 IS - 2753-4294 (Electronic) IS - 2753-4294 (Linking) VI - 4 IP - 2 DP - 2026 TI - Factors associated with knowledge, attitude and practice of micronutrients among adolescents in Madhyabindu Municipality: a cross-sectional study. PG - e002189 LID - 10.1136/bmjph-2024-002189 [doi] LID - e002189 AB - INTRODUCTION: Micronutrients, which include essential vitamins and minerals required in trace amounts, play crucial roles in various physiological processes, such as immune function, cognitive development and overall health. Several previous studies in Nepal have addressed general nutrition and malnutrition trends, few have specifically explored micronutrient-related knowledge and dietary behaviours, particularly among adolescents with attention given to micronutrients in particular. Therefore, this study aims to assess the level of awareness, perceptions and dietary practices related to micronutrients among adolescents. METHODS: A school-based cross-sectional study was conducted between October and December 2022 among 755 adolescents in Madhyabindu Municipality, Nepal. The study employed multistage random sampling with a validated self-administered questionnaire distributed to participants. Statistical analyses, including chi(2) tests and logistic regression, were performed with significance set at p values <0.05 and <0.001 via the SPSS V.16.0. RESULTS: Adequate knowledge of micronutrient-rich foods was observed in 51.52% of the participants, whereas 47.94% had positive attitudes and 42.38% demonstrated good consumption practices. Higher knowledge levels were linked to higher grades (adjusted OR (AOR)=1.47, 95% CI 0.90 to 2.37), belonging to the advantageous ethnic group (AOR=2.40, 95% CI 1.14 to 3.65), maternal education (primary: AOR=1.91, 95% CI 1.06 to 3.47; secondary: AOR=3.02, 95% CI 1.44 to 6.32) and curriculum nutrition content (AOR=1.92, 95% CI 1.30 to 2.81). Good dietary practices were associated with ethnicity (AOR=3.59, 95% CI 1.89 to 6.79), family income (AOR=2.14, 95% CI 1.18 to 3.86), maternal occupation (AOR=1.73, 95% CI 1.05 to 2.86) and paternal occupation (AOR=1.71, 95% CI 1.01 to 2.90). CONCLUSION: This study highlights a significant gap between adolescents' knowledge and their actual consumption or the dietary practices related to micronutrients. There is a pressing need for targeted educational interventions, particularly those involving parents. Enhancing school curricula to include comprehensive and detailed education on micronutrients-especially folate, zinc and vitamins C and D-is crucial for improving adolescent health outcomes. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. Published by BMJ Group. FAU - Shrestha, Tripti AU - Shrestha T AD - Department of Public Health, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal. FAU - Pokhrel, Poonam AU - Pokhrel P AUID- ORCID: 0009-0002-0974-7664 AD - Department of Public Health, Manmohan Memorial Institute of Health Sciences, Kathmandu, Nepal. AD - Public Health Arena, Kathmandu, Nepal. AD - Central Department of International Relations and Diplomacy, Tribhuvan University, Kathmandu, Nepal. FAU - Thapa, Milan AU - Thapa M AUID- ORCID: 0009-0004-0148-4956 AD - Public Health Arena, Kathmandu, Nepal. AD - Nepal Health Frontiers, Kathmandu, Bagmati, Nepal. AD - Progress Inc, Maharajgunj, Kathmandu, Nepal. FAU - Paudel, Kiran AU - Paudel K AUID- ORCID: 0000-0002-5590-4133 AD - Nepal Health Frontiers, Kathmandu, Bagmati, Nepal. FAU - Bhusal, Sandesh AU - Bhusal S AUID- ORCID: 0000-0002-3060-5823 AD - Nepal Health Frontiers, Kathmandu, Bagmati, Nepal. FAU - Adhikari, Tara Ballav AU - Adhikari TB AUID- ORCID: 0000-0002-7654-5483 AD - Nepal Health Frontiers, Kathmandu, Bagmati, Nepal. LA - eng PT - Journal Article DEP - 20260522 PL - England TA - BMJ Public Health JT - BMJ public health JID - 9918697578906676 PMC - PMC13202188 OTO - NOTNLM OT - Adolescent OT - Cross-Sectional Studies OT - Public Health COIS- Competing interests: None declared. EDAT- 2026/05/28 06:32 MHDA- 2026/05/28 06:33 PMCR- 2026/05/22 CRDT- 2026/05/28 04:38 PHST- 2024/10/15 00:00 [received] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/05/28 06:33 [medline] PHST- 2026/05/28 06:32 [pubmed] PHST- 2026/05/28 04:38 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - bmjph-2024-002189 [pii] AID - 10.1136/bmjph-2024-002189 [doi] PST - epublish SO - BMJ Public Health. 2026 May 22;4(2):e002189. doi: 10.1136/bmjph-2024-002189. eCollection 2026. PMID- 42205492 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260528 LR - 20260813 IS - 2516-5410 (Electronic) IS - 2096-6938 (Print) IS - 2516-5410 (Linking) VI - 9 IP - 3 DP - 2026 TI - Feasibility of neonatal intravenous nutrition for the management of gastroschisis in sub-Saharan Africa. PG - e001133 LID - 10.1136/wjps-2025-001133 [doi] LID - e001133 AB - INTRODUCTION: Parenteral nutrition (PN) is a life-saving intervention for neonates with gastroschisis. As most low and middle-income countries lack access to comprehensive neonatal PN, we evaluated the feasibility and safety of a pragmatic intravenous nutrition strategy for neonates with gastroschisis in sub-Saharan Africa. METHODS: Local protocols for partial parenteral nutritional support and early enteral feeding were developed across the seven pediatric surgery centers participating in the Gastroschisis Interventional Study (n=192). Protocols aimed to provide up to 100 kcal/kg/day using 10% dextrose as maintenance fluid, with amino acid preparations and lipid emulsions added when locally available. Trophic breastmilk was commenced on admission, with enteral feeds advanced from the day following defect closure. RESULTS: In the postintervention phase (n=127), all centers administered 10% dextrose as maintenance fluid. Six centers provided parenteral amino acid, and two centers additionally provided parenteral lipid. The proportion of neonates receiving parenteral nutritional support with 10% dextrose and amino acids increased from 18.5% to 66.1% between the pre- and postintervention phases. The median duration of parenteral nutritional support among survivors was 14 days (interquartile range (IQR): 9-22 days). Intravenous nutritional support was mainly administered by peripheral venous access, with no major clinical complications observed. CONCLUSIONS: Partial neonatal intravenous nutritional support using locally available products was feasible and safe across study centers. This approach represents a pragmatic interim strategy in settings where neonatal PN is unavailable. Expanding access to neonatal PN remains essential to achieving Sustainable Development Goal 3.2 to end preventable neonatal deaths by 2030. CI - Copyright (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Wright, Naomi AU - Wright N AD - Department of Paediatric Surgery, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. FAU - Alberti, Piero AU - Alberti P AUID- ORCID: 0000-0002-5429-3473 AD - Department of Paediatric Surgery, King's College Hospital, London, UK. FAU - Olaiya, Aarinola AU - Olaiya A AD - Department of Paediatric Surgery, King's College Hospital, London, UK. FAU - Abantanga, Francis AU - Abantanga F AD - Department of Surgery, Tamale Teaching Hospital, Tamale, Ghana. FAU - Abdul-Mumin, Alhassan AU - Abdul-Mumin A AD - Department of Surgery, Tamale Teaching Hospital, Tamale, Ghana. FAU - Amoah, Michael AU - Amoah M AD - Department of Surgery, Komfo Anokye Teaching Hospital, Kumasi, Ghana. FAU - Appeadu-Mensah, William AU - Appeadu-Mensah W AD - Department of Paediatric Surgery, Korle Bu Teaching Hospital, Accra, Ghana. FAU - Bokhary, Zaitun AU - Bokhary Z AD - Department of Paediatric Surgery, Muhimbili National Hospital, Dar es Salaam, Tanzania. FAU - Bvulani, Bruce AU - Bvulani B AD - Department of Paediatric Surgery, University Teaching Hospital, Lusaka, Zambia. FAU - Mulewa, Mulenga AU - Mulewa M AD - Department of Paediatric Surgery, Arthur Davison Children Hospital, Ndola, Zambia. FAU - Nandi, Bip AU - Nandi B AD - Department of Paediatric Surgery, Kamuzu Central Hospital, Lilongwe, Malawi. FAU - Nimako, Boateng AU - Nimako B AD - Department of Surgery, Komfo Anokye Teaching Hospital, Kumasi, Ghana. FAU - Sama Philipo, Godfrey AU - Sama Philipo G AD - Department of Paediatric Surgery, Muhimbili National Hospital, Dar es Salaam, Tanzania. FAU - Tabiri, Stephen AU - Tabiri S AD - Department of Surgery, Tamale Teaching Hospital, Tamale, Ghana. FAU - Yifieyeh, Abiboye AU - Yifieyeh A AD - Department of Surgery, Komfo Anokye Teaching Hospital, Kumasi, Ghana. FAU - Arnold, Kate AU - Arnold K AD - Department of Nutrition and Dietetics, King's College Hospital, London, UK. FAU - Greenough, Anne AU - Greenough A AD - Department of Women and Children's Health, School of Life Sciences, Faculty of Life Science and Medicine, King's College London, London, UK. FAU - Sevdalis, Nick AU - Sevdalis N AD - Centre for Behavioural and Implementation Science Interventions, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. FAU - Leather, Andrew AU - Leather A AD - Department of Population Health Sciences, King's College London, London, UK. FAU - Naik, Sandhia AU - Naik S AD - Department of Paediatric Gastroenterology, The Royal London Hospital, London, UK. FAU - Ade-Ajayi, Niyi AU - Ade-Ajayi N AD - Department of Paediatric Surgery, King's College Hospital, London, UK. LA - eng PT - Journal Article DEP - 20260522 PL - England TA - World J Pediatr Surg JT - World journal of pediatric surgery JID - 101761337 PMC - PMC13202163 OTO - NOTNLM OT - Child Health OT - Child Nutrition Sciences OT - Health services research OT - Infant Nutrition Disorders COIS- NS is the director of London Safety and Training Solutions Ltd, which offers training and improvement and implementation solutions to healthcare organizations and the pharmaceutical industry. EDAT- 2026/05/28 06:33 MHDA- 2026/05/28 06:34 PMCR- 2026/05/22 CRDT- 2026/05/28 04:37 PHST- 2025/11/18 00:00 [received] PHST- 2026/03/29 00:00 [accepted] PHST- 2026/05/28 06:34 [medline] PHST- 2026/05/28 06:33 [pubmed] PHST- 2026/05/28 04:37 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - wjps-2025-001133 [pii] AID - 10.1136/wjps-2025-001133 [doi] PST - epublish SO - World J Pediatr Surg. 2026 May 22;9(3):e001133. doi: 10.1136/wjps-2025-001133. eCollection 2026. PMID- 42205458 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260528 LR - 20260813 IS - 1792-1015 (Electronic) IS - 1792-0981 (Print) IS - 1792-0981 (Linking) VI - 32 IP - 1 DP - 2026 Jul TI - Genetic etiology and phenotypic characteristics of fetuses with 11q deletion syndrome (11q23.3-q25). PG - 185 LID - 10.3892/etm.2026.13180 [doi] LID - 185 AB - The 11q deletion (11q-) syndrome is a rare consecutive polygenic deletion disorder. Characterization of the clinical features, genetic etiology and diagnostic strategies associated with 11q deletion syndrome in the prenatal setting is important to understand this syndrome in its entirety. A retrospective review at Longgang District Maternity & Child Healthcare Hospital of Shenzhen City (Shenzhen, China) involving four fetuses diagnosed with 11q- syndrome was conducted to examine the clinical features of this syndrome. The cases were identified through prenatal screening, including maternal serum biochemistry, non-invasive prenatal screening (NIPS), chromosomal microarray analysis (CMA) and karyotyping. Pregnant women with high-risk results from NIPS or prenatal serological screening received early interventional prenatal diagnosis and genetic counseling. Of the two cases that showed a high-risk of 11q- by NIPS, invasive diagnostic procedures confirmed the presence of large terminal deletions on chromosome 11q, encompassing telomeric regions. CMA identified the deletions while karyotyping revealed underlying structural rearrangements, including balanced translocations in both cases. Prenatal ultrasound identified cardiac anomalies, such as ventricular septal defects and truncus arteriosus. The variability and incomplete penetrance of these malformations suggest the influence of polygenic (e.g., modifier genes, genetic background, copy number variations), epigenetic (e.g., DNA methylation, histone modification) and environmental factors (e.g., diet, lifestyle, exposure to toxins). The results demonstrated that the phenotypic expression of 11q- syndrome varies according to the size and gene content of the deleted region. The integration of CMA and karyotyping improves diagnostic accuracy and elucidates the origin of chromosomal alterations. In the single case present in the current study that involved a parental chromosomal translocation, karyotyping was essential for determining the risk of recurrence. These findings contribute to a more precise understanding of genotype-phenotype associations and support the provision of informed prenatal counseling and the clinical management of 11q- syndrome. CI - Copyright: (c) 2026 Zhang et al. FAU - Zhang, Tong AU - Zhang T AD - Central Laboratory (Genetics Laboratory), Longgang District Maternity and Child Healthcare Hospital of Shenzhen City [Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College], Shenzhen, Guangdong 518172, P.R. China. FAU - Cong, Xiaoyi AU - Cong X AD - Central Laboratory (Genetics Laboratory), Longgang District Maternity and Child Healthcare Hospital of Shenzhen City [Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College], Shenzhen, Guangdong 518172, P.R. China. FAU - Li, Zhenming AU - Li Z AD - Central Laboratory (Genetics Laboratory), Longgang District Maternity and Child Healthcare Hospital of Shenzhen City [Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College], Shenzhen, Guangdong 518172, P.R. China. FAU - Cao, Xianzhen AU - Cao X AD - Central Laboratory (Genetics Laboratory), Longgang District Maternity and Child Healthcare Hospital of Shenzhen City [Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College], Shenzhen, Guangdong 518172, P.R. China. FAU - Hu, Liang AU - Hu L AD - Central Laboratory (Genetics Laboratory), Longgang District Maternity and Child Healthcare Hospital of Shenzhen City [Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College], Shenzhen, Guangdong 518172, P.R. China. FAU - Luo, Xiaojin AU - Luo X AD - Central Laboratory (Genetics Laboratory), Longgang District Maternity and Child Healthcare Hospital of Shenzhen City [Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College], Shenzhen, Guangdong 518172, P.R. China. FAU - Liu, Yanan AU - Liu Y AD - Central Laboratory (Genetics Laboratory), Longgang District Maternity and Child Healthcare Hospital of Shenzhen City [Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College], Shenzhen, Guangdong 518172, P.R. China. FAU - Liu, Weiqiang AU - Liu W AD - Central Laboratory (Genetics Laboratory), Longgang District Maternity and Child Healthcare Hospital of Shenzhen City [Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College], Shenzhen, Guangdong 518172, P.R. China. FAU - Wei, Fengxiang AU - Wei F AD - Central Laboratory (Genetics Laboratory), Longgang District Maternity and Child Healthcare Hospital of Shenzhen City [Affiliated Shenzhen Women and Children's Hospital (Longgang) of Shantou University Medical College], Shenzhen, Guangdong 518172, P.R. China. LA - eng PT - Journal Article DEP - 20260508 PL - Greece TA - Exp Ther Med JT - Experimental and therapeutic medicine JID - 101531947 PMC - PMC13203314 OTO - NOTNLM OT - 11q- syndrome OT - Jacobsen syndrome OT - balanced translocation OT - congenital heart abnormalities COIS- The authors declare that they have no competing interests. EDAT- 2026/05/28 06:31 MHDA- 2026/05/28 06:32 PMCR- 2026/05/08 CRDT- 2026/05/28 04:37 PHST- 2025/04/07 00:00 [received] PHST- 2025/08/18 00:00 [accepted] PHST- 2026/05/28 06:32 [medline] PHST- 2026/05/28 06:31 [pubmed] PHST- 2026/05/28 04:37 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - ETM-32-1-13180 [pii] AID - 10.3892/etm.2026.13180 [doi] PST - epublish SO - Exp Ther Med. 2026 May 8;32(1):185. doi: 10.3892/etm.2026.13180. eCollection 2026 Jul. PMID- 42205435 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Association between multiple health behaviors and mental health in Chinese college students: a cross-sectional study. PG - 1792272 LID - 10.3389/fpubh.2026.1792272 [doi] LID - 1792272 AB - BACKGROUND: College students face significant psychological pressures, yet the cumulative effects of multiple concurrent health behaviors on their mental health remain underexplored, particularly in the Chinese context. METHODS: A cross-sectional survey was conducted among 521 college students from Shandong and Guangdong provinces, China. Health behaviors, including physical activity (IPAQ-C), sedentary behavior (SBQ), sleep quality (PSQI), smoking, and alcohol use, were assessed via validated self-report questionnaires. Mental health outcomes were measured using the Personal Wellbeing Index (PWI) and the Depression, Anxiety, and Stress Scales-21 (DASS-21). Multiple linear regression analyses, adjusting for key demographic covariates, were employed to examine associations. RESULTS: Prolonged screen time was consistently associated with poorer mental health, showing negative correlations with personal wellbeing (beta = -0.03, P = 0.036) and positive correlations with stress (beta = 0.24, P = 0.030), depression (beta = 0.32, P = 0.005), and anxiety (beta = 0.25, P = 0.020). Alcohol consumption was negatively associated with personal wellbeing (beta = -0.16, P = 0.040). Interestingly, smoking was negatively associated with stress (beta = -1.37, P = 0.020) and depression (beta = -1.44, P = 0.016). Physical activity (MVPA) showed no statistically significant associations with stress (beta = 0.01, P = 0.750), depression (beta = 0.01, P = 0.630), or anxiety (beta = -0.001, P = 0.490) in the regression models. Furthermore, no significant gender differences were observed in the key health behaviors or mental health scores. CONCLUSION: Unhealthy behaviors, particularly high screen time and alcohol use, are significantly associated with adverse mental health outcomes among Chinese college students. The findings suggest that smoking might be used as a maladaptive coping mechanism. Public health interventions should adopt an integrated approach, simultaneously targeting these co-occurring behavioral risk factors to promote student wellbeing. CI - Copyright (c) 2026 Wang, Mu, Liu, Lyu, Liang and Zhou. FAU - Wang, Qingchun AU - Wang Q AD - School of Sport and Health, Shandong Sport University, Jinan, China. FAU - Mu, Liu AU - Mu L AD - School of Graduate Education, Shandong Sport University, Jinan, China. FAU - Liu, Guifang AU - Liu G AD - School of Physical Education, Shenzhen University, Shenzhen, China. FAU - Lyu, Junming AU - Lyu J AD - School of Physical Education, Shenzhen University, Shenzhen, China. FAU - Liang, Wei AU - Liang W AD - School of Physical Education, Shenzhen University, Shenzhen, China. FAU - Zhou, Lin AU - Zhou L AD - School of Sport and Health, Shandong Sport University, Jinan, China. LA - eng PT - Journal Article DEP - 20260512 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Students/psychology/statistics & numerical data MH - Male MH - Female MH - China/epidemiology MH - *Health Behavior MH - *Mental Health/statistics & numerical data MH - Universities MH - Young Adult MH - Alcohol Drinking/epidemiology MH - Smoking/epidemiology MH - Stress, Psychological/epidemiology MH - Exercise/psychology MH - Sedentary Behavior MH - Surveys and Questionnaires MH - Anxiety/epidemiology MH - Adolescent MH - Depression/epidemiology MH - Screen Time MH - Adult MH - Sleep Quality PMC - PMC13201420 OTO - NOTNLM OT - college students OT - health behaviors OT - mental health OT - screen time OT - sedentary behavior COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author WL declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/05/28 06:32 MHDA- 2026/05/28 06:33 PMCR- 2026/05/12 CRDT- 2026/05/28 04:36 PHST- 2026/01/20 00:00 [received] PHST- 2026/04/04 00:00 [revised] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/05/28 06:33 [medline] PHST- 2026/05/28 06:32 [pubmed] PHST- 2026/05/28 04:36 [entrez] PHST- 2026/05/12 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1792272 [doi] PST - epublish SO - Front Public Health. 2026 May 12;14:1792272. doi: 10.3389/fpubh.2026.1792272. eCollection 2026. PMID- 42204355 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260813 IS - 1476-5543 (Electronic) IS - 0743-8346 (Print) IS - 0743-8346 (Linking) VI - 46 IP - 7 DP - 2026 Jul TI - Bedside ultrasound imaging to measure muscle cross-sectional area in preterm and term infants: a feasibility study. PG - 1216-1223 LID - 10.1038/s41372-026-02730-w [doi] AB - BACKGROUND/OBJECTIVE: Lean body mass is linked to improved outcomes, but infant muscle-specific tools are limited. Bedside ultrasound measurements of muscle cross-sectional area (CSA) may overcome these limitations. STUDY DESIGN: A prospective cohort of 60 infants at two neonatal intensive care units (NICUs) underwent serial ultrasound biceps CSA, rectus femoris CSA, and anthropometric measurements. Intraclass correlation coefficients (ICC) assessed measurement reliability. Spline mixed models examined associations between muscle CSA and birth gestational age, growth, postmenstrual age (PMA), and nutrition. RESULTS: Intra- and inter-rater ICCs ranged from 0.92 to 0.99 and from 0.77 to 0.91. No safety events occurred. Biceps CSA correlated with birth gestational age, PMA, weight, length, head circumference, and mid-upper arm circumference (p /=50% seizure reduction at 24 months, n = 9) or non-responders (n = 8). Thalamic volumes were manually segmented on preoperative T2-weighted magnetic resonance imaging by 2 blinded raters, and we used the rater-averaged values to calculate the left/right volume ratio and asymmetry index. The mean thalamic volume ratio (left/right) was significantly higher in responders than non-responders (1.00 [95% confidence interval 0.97-1.03] vs 0.96 [95% confidence interval 0.92-0.99], p = 0.027), and the asymmetry index also differed between groups (0.00 [95% confidence interval -0.015 to 0.017] vs -0.023 [95% confidence interval -0.040 to -0.006], p = 0.027). Inter-rater reliability was acceptable for absolute volumes but was lower for ratio-based asymmetry indices, suggesting that these derived metrics may be more suitable for group-level comparisons than for single-patient prediction. Epileptogenic laterality determined by electroencephalography did not predict thalamic asymmetry. Relative left thalamic volume reduction was associated with poor vagus nerve stimulation treatment response. Assessment of preoperative thalamic asymmetry on routine structural magnetic resonance imaging may represent a candidate biomarker for predicting vagus nerve stimulation efficacy, pending validation in larger cohorts. FAU - Ujihara, Masaki AU - Ujihara M AD - Department of Neurosurgery, Hokkaido University. FAU - Kawabori, Masahito AU - Kawabori M AD - Department of Neurosurgery, Hokkaido University. FAU - Nakajima, Midori AU - Nakajima M AD - Department of Pediatrics, Hokkaido University. FAU - Ueda, Yuki AU - Ueda Y AD - Department of Pediatrics, Hokkaido University. FAU - Horinouchi, Toru AU - Horinouchi T AD - Department of Psychiatry and Neurology, Hokkaido University. FAU - Egawa, Kiyoshi AU - Egawa K AD - Department of Pediatrics, Hokkaido University. FAU - Kato, Takahiro A AU - Kato TA AD - Department of Psychiatry and Neurology, Hokkaido University. FAU - Fujimura, Miki AU - Fujimura M AD - Department of Neurosurgery, Hokkaido University. LA - eng PT - Journal Article DEP - 20260527 PL - Japan TA - Neurol Med Chir (Tokyo) JT - Neurologia medico-chirurgica JID - 0400775 SB - IM MH - Humans MH - *Vagus Nerve Stimulation MH - *Drug Resistant Epilepsy/therapy/diagnostic imaging MH - *Thalamus/diagnostic imaging/pathology MH - Female MH - Retrospective Studies MH - Male MH - Magnetic Resonance Imaging MH - Treatment Outcome MH - Adult MH - Adolescent MH - Organ Size MH - Young Adult PMC - PMC13441519 OTO - NOTNLM OT - MRI OT - VNS OT - asymmetry OT - epilepsy OT - thalamus COIS- All authors have no conflict of interest. EDAT- 2026/05/28 00:29 MHDA- 2026/07/16 12:40 PMCR- 2026/05/27 CRDT- 2026/05/27 21:13 PHST- 2026/07/16 12:40 [medline] PHST- 2026/05/28 00:29 [pubmed] PHST- 2026/05/27 21:13 [entrez] PHST- 2026/05/27 00:00 [pmc-release] AID - 10.2176/jns-nmc.2025-0409 [doi] PST - ppublish SO - Neurol Med Chir (Tokyo). 2026 Jul 15;66(7):490-499. doi: 10.2176/jns-nmc.2025-0409. Epub 2026 May 27. PMID- 42203160 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2156-5376 (Electronic) IS - 2161-8313 (Print) IS - 2161-8313 (Linking) VI - 17 IP - 7 DP - 2026 Jul TI - Skinfolds Measurement Protocols and Standards: A Narrative Review. PG - 100662 LID - S2161-8313(26)00076-1 [pii] LID - 10.1016/j.advnut.2026.100662 [doi] LID - 100662 AB - Skinfold thickness assessment is one of the most widely used anthropometric methods for estimating subcutaneous adipose tissue and overall body adiposity in clinical, epidemiological, and sports settings. Despite its long-standing application, substantial heterogeneity persists across measurement protocols and standardization systems, potentially affecting reproducibility and comparability across studies. This narrative review aims to critically synthesize the historical, conceptual, methodological, and technical development of the main skinfold measurement protocols and standards, systematically compare their characteristics, and examine their methodological and practical implications for research and clinical applications. A targeted bibliographic synthesis of classic textbooks, consensus manuals, and original peer-reviewed studies on surface anthropometry was conducted. Seventeen anatomical skinfold sites and 31 distinct technical descriptions were identified, including 22 site-selection protocols and 9 measurement standards. Five established standards were comparatively analyzed, with emphasis on anatomical landmarking, fold orientation, spatial pinching procedures, and temporal reading control. Similarities were observed in general technical principles, including right-side assessment, perpendicular caliper application, controlled reading time, and maintenance of fold elevation. However, persistent divergences were identified in anatomical definitions, fold orientation, landmark precision, spatial positioning of pinch and caliper jaws, and recommended reading time, with greater heterogeneity at trunk sites than limb sites. Although the reviewed protocols and standards were developed for broad application across age groups, this review primarily reflected their use in adolescents and adults, as skinfold assessment in infants and young children involves additional considerations related to growth dynamics and rapid changes in adipose tissue. Skinfold measurement protocols and standards are not interchangeable and reflect pluralistic, complementary international initiatives rather than a single institutional standardization process. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Cintra, Joaquim H AU - Cintra JH AD - Postgraduate Program in Translational Medicine, Department of Endocrinology, Federal University of Ceara, Fortaleza, Brazil. Electronic address: joaquimcintra@hotmail.com. FAU - Costa-Pereira, Jarson P AU - Costa-Pereira JP AD - Postgraduate Program in Nutrition, Department of Nutrition, Federal University of Pernambuco, Recife, Brazil. FAU - Ripka, Wagner L AU - Ripka WL AD - Graduation Program in Biomedical Engineering, Federal University of Technology - Parana, Curitiba, Brazil. FAU - Freire-Correia, Maria I AU - Freire-Correia MI AD - University of Fortaleza, Fortaleza, Brazil. FAU - Jesus, Filipe A AU - Jesus FA AD - Exercise and Health Laboratory, Interdisciplinary Center for the Study of Human Performance, Faculdade Motricidade Humana, Universidade de Lisboa, Cruz-Quebrada, Portugal; Atlantica, Fabrica da Polvora de Barcarena, Instituto Universitario, Barcarena, Portugal. FAU - Silva, Analiza M AU - Silva AM AD - Exercise and Health Laboratory, Interdisciplinary Center for the Study of Human Performance, Faculdade Motricidade Humana, Universidade de Lisboa, Cruz-Quebrada, Portugal; Department of Movement Sciences and Sports Training, School of Sport Sciences, The University of Jordan, Amman, Jordan. FAU - Sardinha, Luis B AU - Sardinha LB AD - Exercise and Health Laboratory, Interdisciplinary Center for the Study of Human Performance, Faculdade Motricidade Humana, Universidade de Lisboa, Cruz-Quebrada, Portugal. FAU - Lohman, Timothy G AU - Lohman TG AD - Emeritus Faculty, University of Arizona, Tucson, AZ, United States. FAU - Heymsfield, Steven B AU - Heymsfield SB AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. LA - eng PT - Journal Article PT - Review DEP - 20260526 PL - United States TA - Adv Nutr JT - Advances in nutrition (Bethesda, Md.) JID - 101540874 SB - IM MH - Humans MH - *Skinfold Thickness MH - *Anthropometry/methods MH - Reproducibility of Results MH - Adiposity PMC - PMC13276579 OTO - NOTNLM OT - anthropometry OT - body composition OT - protocols OT - reference standards OT - skinfold thickness COIS- Conflict of interest JHC is a Level 3 instructor at the International Society for the Advancement of Kinanthropometry. JPC-P has received speaking fees/honoraria from Fresenius Kabi, Danone Nutricia Brazil, and Prodiet Medical Nutrition. SBH serves on the Medical Advisory Boards of Tanita Corporation, Novo Nordisk, Abbott, Novartis, Versanis, and Medifast. EDAT- 2026/05/28 00:30 MHDA- 2026/07/17 12:41 PMCR- 2026/05/26 CRDT- 2026/05/27 19:35 PHST- 2026/03/06 00:00 [received] PHST- 2026/05/13 00:00 [revised] PHST- 2026/05/21 00:00 [accepted] PHST- 2026/07/17 12:41 [medline] PHST- 2026/05/28 00:30 [pubmed] PHST- 2026/05/27 19:35 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - S2161-8313(26)00076-1 [pii] AID - 100662 [pii] AID - 10.1016/j.advnut.2026.100662 [doi] PST - ppublish SO - Adv Nutr. 2026 Jul;17(7):100662. doi: 10.1016/j.advnut.2026.100662. Epub 2026 May 26. PMID- 42202864 OWN - NLM STAT- Publisher LR - 20260625 IS - 1439-3964 (Electronic) IS - 0172-4622 (Linking) DP - 2026 Jun 25 TI - Concurrent Validity and Reliability of an On-Floor 12 m Shuttle Run Test for Young Gymnasts. LID - 10.1055/a-2884-0287 [doi] AB - Adequate endurance capacity is crucial for training quality, recovery, and long-term development of gymnasts. The shuttle run test is a valid and efficient field test for estimating aerobic capacity (i.e., maximum oxygen uptake) in children and adolescents. Adapted to the indoor restrictions of an artistic gymnastics floor, a feasible 12 m shuttle run test was examined for its validity and absolute and relative reliability. Young gymnasts (n = 69; age: 12.3+/-1.6 y; body mass index: 17.6+/-2.0 kg*m(-2); training experience: 6.6+/-2.3 y), competing at trained and highly trained levels in artistic, trampoline, and rhythmic gymnastics, initially performed a laboratory treadmill test and two further 12 m shuttle run tests on a gymnastics floor. Oxygen uptake during laboratory and on-floor testing was assessed until objective exhaustion criteria were reached. The 12 m shuttle run test demonstrated good validity for relative maximal oxygen uptake (intraclass correlation coefficient(2,1): 0.82 and 95% confidence interval: 0.72-0.88) with moderate limits of agreement (95% confidence interval: -10.7-9.2 mL*kg(-1)*min(-1)) between the treadmill and the 12 m shuttle run test. The test-retest reliability of the 12 m shuttle run test for relative maximal oxygen uptake was good (intraclass correlation coefficient(2,1): 0.79, 95% confidence interval: 0.64-0.89). The on-floor 12 m shuttle run test serves as a sufficiently valid and reliable endurance testing tool, enabling the regular assessment with a potential classification of aerobic capacity requirements. CI - Thieme. All rights reserved. FAU - Fay, Lina AU - Fay L AUID- ORCID: 0009-0005-9164-8420 AD - Institute for Exercise Science and Sport Informatics, Department of Interventional Research in Exercise Science, Germany, Cologne. FAU - Rappelt, Ludwig AU - Rappelt L AD - Institute for Exercise Science and Sport Informatics, Department of Interventional Research in Exercise Science, Germany, Cologne. FAU - Held, Steffen AU - Held S AD - IST University of Applied Sciences, Sport and Management, Germany, Dusseldorf. FAU - Donath, Lars AU - Donath L AD - Institute for Exercise Science and Sport Informatics, Department of Interventional Research in Exercise Science, Germany, Cologne. LA - eng GR - 072019/23/Bundesinstitut fur Sportwissenschaft/ PT - Journal Article DEP - 20260625 PL - Germany TA - Int J Sports Med JT - International journal of sports medicine JID - 8008349 SB - IM COIS- The authors declare that they have no conflict of interest. EDAT- 2026/05/28 00:29 MHDA- 2026/05/28 00:29 CRDT- 2026/05/27 19:03 PHST- 2026/05/28 00:29 [pubmed] PHST- 2026/05/28 00:29 [medline] PHST- 2026/05/27 19:03 [entrez] AID - 10.1055/a-2884-0287 [doi] PST - aheadofprint SO - Int J Sports Med. 2026 Jun 25. doi: 10.1055/a-2884-0287. PMID- 42201038 OWN - NLM STAT- MEDLINE DCOM- 20260527 LR - 20260813 IS - 2076-3271 (Electronic) IS - 2076-3271 (Linking) VI - 14 IP - 2 DP - 2026 May 8 TI - Telerehabilitation and Face-to-Face Exergame Delivery Modalities to Improve Postural Control in Children with Cerebral Palsy: A Randomised Controlled Trial. LID - 10.3390/medsci14020246 [doi] LID - 246 AB - Background: Low-cost virtual reality exergames may help maintain and improve postural control in children with spastic hemiplegia cerebral palsy (CP). This study aimed to evaluate the comparative effectiveness of the same six-week, low-cost exergame programme delivered via telerehabilitation (TR) and face-to-face (FF) in CP children. Methods: In this randomised controlled trial, 15 CP patients completed 18 sessions over 6 weeks. The TR group received remotely delivered sessions, whereas the FF control group completed in-person sessions with a physiotherapist. Outcomes were assessed at baseline; weeks 2, 4, and 6; and follow-ups at weeks 8 and 10. Postural control (centre-of-pressure sway area; CoP(sway)) was measured during eyes open (EO), eyes closed (EC), voluntary mediolateral sway to a 30 bpm auditory cue (EO/EC), and during exergames targeting mediolateral (ML-WS) and anteroposterior (AP-WS) weight-shifting. Timed Up and Go (TUG) and Modified Modified Ashworth Scale (MMAS) were also assessed. Results: At week 6, both TR and FF significantly reduced CoP(sway) (TR: p = 0.001, EC; FF: p = 0.01, EO). TR also improved dynamic postural control (p < 0.05) and TUG scores (p = 0.03), with functional gains sustained until week 10. Between-group comparisons revealed that TR achieved significantly greater reductions in AP weight-shifting (SD(ML), p = 0.001; V(ML), p = 0.004) and TUG (p = 0.009) than FF, with these advantages persisting throughout follow-up as revealed by post hoc analysis. Conversely, only FF significantly reduced ankle muscle tone (MMAS, p = 0.05). TR demonstrated broader improvements in secondary CoP metrics and superior long-term retention of functional mobility gains. Conclusions: Both six-week exergame interventions led to improvements in postural control. This trial demonstrated that telerehabilitation is a viable, comparable alternative to face-to-face delivery. Long-term retention suggests both modalities are complementary, offering flexible solutions to enhance routine physiotherapy service pathways. These findings provide a basis for validating these models across larger clinical cohorts. FAU - Gatica-Rojas, Valeska AU - Gatica-Rojas V AD - Human Motor Control Laboratory, Faculty of Health Sciences, Universidad de Talca, Av. Lircay S/N, Talca 3460000, Chile. FAU - Cofre Lizama, L Eduardo AU - Cofre Lizama LE AUID- ORCID: 0000-0002-3490-4521 AD - Department of Allied Health, School of Health Sciences, Swinburne University of Technology, Melbourne, VIC 3122, Australia. AD - Department of Medicine (Royal Melbourne Hospital), The University of Melbourne, Melbourne, VIC 3052, Australia. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20260508 PL - Switzerland TA - Med Sci (Basel) JT - Medical sciences (Basel, Switzerland) JID - 101629322 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology/rehabilitation MH - Child MH - Female MH - *Postural Balance/physiology MH - Male MH - Telerehabilitation MH - *Exergaming MH - Video Games MH - *Exercise Therapy/methods MH - Treatment Outcome PMC - PMC13214957 OTO - NOTNLM OT - balance control OT - cerebral palsy OT - children OT - exergame OT - physical therapy OT - postural control OT - telerehabilitation OT - virtual reality COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/05/27 12:35 MHDA- 2026/05/27 12:36 PMCR- 2026/05/08 CRDT- 2026/05/27 10:14 PHST- 2026/03/25 00:00 [received] PHST- 2026/04/27 00:00 [revised] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/05/27 12:36 [medline] PHST- 2026/05/27 12:35 [pubmed] PHST- 2026/05/27 10:14 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - medsci14020246 [pii] AID - medsci-14-00246 [pii] AID - 10.3390/medsci14020246 [doi] PST - epublish SO - Med Sci (Basel). 2026 May 8;14(2):246. doi: 10.3390/medsci14020246. PMID- 42200642 OWN - NLM STAT- MEDLINE DCOM- 20260527 LR - 20260813 IS - 1948-965X (Electronic) IS - 1682-3141 (Print) IS - 1682-3141 (Linking) VI - 34 IP - 3 DP - 2026 Jun 1 TI - Effects of Applying Gamified Exercise in Health Education Classes on Physical Activity Levels in School-Aged Children: A Randomized Controlled Pilot Study. PG - e461 LID - 10.1097/jnr.0000000000000746 [doi] AB - BACKGROUND: Declining physical activity (PA) among schoolchildren is a global issue. Schools play a crucial role in children's PA, as they spend most of their waking hours at school. Therefore, developing an easy-to-implement school-based physical activity program is important. PURPOSE: This study was designed to evaluate the effectiveness of using gamified exercise in health education classes to enhance PA levels among schoolchildren. METHODS: A randomized controlled pilot design was applied. Two elementary schools were randomly assigned, respectively, to an experimental group (EG; n = 47) that received a gamified fitness program with reciprocal physical education and a control group (CG; n = 44) that received reciprocal physical education only. The gamified fitness program, developed and validated by a multidisciplinary team, was delivered during health education classes. PA levels were measured using AI-wireless wrist sensors worn during schooltime at three points, including the first week (T1), sixth week (T2), and 12th week (T3) of the program. Program feasibility was assessed using participant satisfaction and analyzed using Generalized Estimating Equations (GEE). RESULTS: PA levels at the three time points (T3-T1) were significantly different between the two groups. The results of GEE analysis revealed that daily steps (mean difference +/- SE: 4,068.4 +/- 1,144.1 steps), total PA (84.4 +/- 16.0 min), light PA (LPA; 72.6 +/- 15.3 min), and moderate to vigorous PA (MVPA; 12.1 +/- 2.9 min) increased significantly more over time in the EG than the CG. Moreover, approximately 85% of the EG identified the PA program as being satisfactory and feasible. CONCLUSIONS/IMPLICATIONS FOR PRACTICE: The results of the pilot trial conducted in this study demonstrate the feasibility of integrating gamified exercise into school health education classes and the potential of this program to increase physical activity levels in schoolchildren significantly. The success of the developed program is attributable to its multidisciplinary approach, engaging design, and focus on core strength and cardiorespiratory endurance. Gamified fitness in health education may be used to promote activity, support inclusive policies, and reduce disparities among school-age students. CI - Copyright (c) 2026 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the Taiwan Nurses Association. FAU - Hsiao, Li-Chun AU - Hsiao LC AD - Department of Nursing, College of Medicine, National Cheng Kung University, Tainan, Taiwan. FAU - Wang, Chi-Jane AU - Wang CJ AUID- ORCID: 0000-0001-8204-8574 AD - Department of Nursing, College of Medicine, National Cheng Kung University, Tainan, Taiwan. FAU - Yang, Ya-Ping AU - Yang YP AD - Department of Nursing, National Tainan Junior College of Nursing, Tainan, Taiwan. FAU - Lin, Jong-Ni AU - Lin JN AUID- ORCID: 0000-0003-3414-809 AD - Department of Post-Baccalaureate Nursing, and Department of Nursing, Da-Yeh University, Changhua, Taiwan. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260601 PL - China (Republic : 1949- ) TA - J Nurs Res JT - The journal of nursing research : JNR JID - 101128757 SB - IM MH - Humans MH - Pilot Projects MH - Child MH - Male MH - Female MH - *Exercise/psychology MH - *Health Education/methods/standards MH - *Gamification MH - Schools/organization & administration PMC - PMC13200866 OTO - NOTNLM OT - gamification OT - inclusive curriculum OT - multidisciplinary OT - physical activity OT - school-age children COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 12:34 MHDA- 2026/05/27 12:35 PMCR- 2026/05/25 CRDT- 2026/05/27 09:03 PHST- 2024/11/12 00:00 [received] PHST- 2025/08/22 00:00 [accepted] PHST- 2026/05/27 12:35 [medline] PHST- 2026/05/27 12:34 [pubmed] PHST- 2026/05/27 09:03 [entrez] PHST- 2026/05/25 00:00 [pmc-release] AID - 00134372-202606000-00009 [pii] AID - JNR-D-24-00451 [pii] AID - 10.1097/jnr.0000000000000746 [doi] PST - epublish SO - J Nurs Res. 2026 Jun 1;34(3):e461. doi: 10.1097/jnr.0000000000000746. PMID- 42200165 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 1177-889X (Print) IS - 1177-889X (Electronic) IS - 1177-889X (Linking) VI - 20 DP - 2026 TI - Digital Health Engagement Regarding Lumbar Disc Herniation in Terms of Exercise Adherence: Integrating Variable-Centered and Person-Centered Perspectives. PG - 603051 LID - 10.2147/PPA.S603051 [doi] LID - 603051 AB - BACKGROUND: Exercise adherence is pivotal for Lumbar Disc Herniation (LDH) rehabilitation, yet remains suboptimal. Digital health offers support, but patient engagement varies significantly. Current research lacks an integrated perspective examining variable-centered general mechanisms and person-centered heterogeneity in digital health engagement and adherence. AIM: This study aimed to: (1) elucidate the variable-centered mechanism by testing the mediating role of health information seeking behavior (HISB) between eHealth literacy and exercise adherence; and (2) identify person-centered latent profiles of digital health engagement to predict adherence levels. METHODS: This cross-sectional study (from July to November 2025) involved 346 LDH patients. Digital health engagement was operationalized using the eHealth Literacy Scale (eHEALS) and the Health Information Seeking Behavior Scale (HISB). Exercise adherence was assessed using a validated LDH-specific scale. Data were analyzed using Structural Equation Modeling (SEM) and Latent Profile Analysis (LPA). RESULTS: SEM confirmed eHealth literacy positively predicted adherence directly and indirectly via HISB (mediation effect: 30.6%). LPA identified four profiles: "Digital Disengaged" (36.4%), "Passive Spectators" (36.1%), "Digital Champions" (22.3%), and "Distress-Driven Seekers" (5.2%). While youth and higher socioeconomic status predicted "Digital Champions", severe functional disability (ODI) was the strongest predictor for "Distress-Driven Seekers" (OR=2.76, P<0.05). "Distress-Driven Seekers" achieved high adherence, comparable to "Digital Champions" (P>0.05) and superior to others (P<0.001). CONCLUSION: HISB serves as a crucial mechanism linking eHealth literacy to rehabilitation adherence. Severe disability distress drives high-intensity information seeking, compensating for low literacy and enabling high adherence in "Distress-Driven Seekers". Personalized digital health interventions should be developed to accommodate diverse engagement patterns. Notably, "Distress-Driven Seekers" require targeted clinical guidance and "information prescriptions" to mitigate risks of medical misinformation, health anxiety, and potential secondary injuries caused by inappropriate self-management. CI - (c) 2026 Xu et al. FAU - Xu, Xingxing AU - Xu X AD - Department of TCM Nursing Clinic, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, People's Republic of China. FAU - Qu, Qing AU - Qu Q AD - Department of Massage, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, People's Republic of China. FAU - Chen, Tingting AU - Chen T AD - Department of TCM Nursing Clinic, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, People's Republic of China. FAU - Shao, Xueying AU - Shao X AD - Department of TCM Nursing Clinic, Hangzhou TCM Hospital Affiliated to Zhejiang Chinese Medical University, Hangzhou, Zhejiang Province, People's Republic of China. LA - eng PT - Journal Article DEP - 20260520 PL - New Zealand TA - Patient Prefer Adherence JT - Patient preference and adherence JID - 101475748 PMC - PMC13199742 OTO - NOTNLM OT - digital health OT - eHealth literacy OT - exercise adherence OT - health information-seeking behavior OT - latent profile analyses OT - lumbar disc herniation OT - person-centered and variable-centered COIS- The authors confirm that there are no conflicts of interest for this work. EDAT- 2026/05/27 12:20 MHDA- 2026/05/27 12:21 PMCR- 2026/05/20 CRDT- 2026/05/27 04:36 PHST- 2026/02/12 00:00 [received] PHST- 2026/05/14 00:00 [accepted] PHST- 2026/05/27 12:21 [medline] PHST- 2026/05/27 12:20 [pubmed] PHST- 2026/05/27 04:36 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - 603051 [pii] AID - 10.2147/PPA.S603051 [doi] PST - epublish SO - Patient Prefer Adherence. 2026 May 20;20:603051. doi: 10.2147/PPA.S603051. eCollection 2026. PMID- 42198548 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 2305-6304 (Electronic) IS - 2305-6304 (Linking) VI - 14 IP - 5 DP - 2026 May 12 TI - Early Pregnancy Targeted Exposome: Biological Response and Maternal BMI. LID - 10.3390/toxics14050421 [doi] LID - 421 AB - Physiological and metabolic adaptations during pregnancy may increase susceptibility to harmful environmental chemicals. High maternal BMI that perturbs the metabolic, inflammatory, and hormonal milieus could modulate toxicant effects on pregnancy outcomes. First-trimester targeted urinary exposomes of 119 women (BMI >/= 25 = 55; BMI < 25 = 64) from the Michigan Mother-Infant Pair cohort were profiled to assess how BMI influences urinary exposomes and related biological responses. A validated approach measured 96 chemicals and biomarkers of oxidative stress and glucocorticoids. Women in both groups reported similar lifestyles and consumer product use. Women with high BMI had lower urinary concentrations of several chemicals than women with low BMI. Phytoestrogens, polycyclic aromatic hydrocarbons, and insect repellants showed a higher magnitude of positive associations with other markers of exposure, oxidative and glucocorticoid stress in the high-BMI group, while UV filters, flame retardants, and phthalates showed a higher magnitude of positive associations with oxidative stress markers in the low-BMI group. The patterns of associations of exposure markers with stress markers and pregnancy outcomes (gestational age and birthweight) differed by maternal BMI. This highlights the importance of incorporating maternal BMI into the evaluation of exposure burden and its effects, as a factor that may actively shape biological responses. FAU - Saadat, Nadia AU - Saadat N AUID- ORCID: 0000-0001-8726-9245 AD - Department of Pediatrics, University of Michigan, 7510 MSRB 1, 1500 W. Medical Center Drive, Ann Arbor, MI 48109, USA. FAU - Thangaraj, Soundara Viveka AU - Thangaraj SV AUID- ORCID: 0000-0003-4902-468X AD - Department of Pediatrics, University of Michigan, 7510 MSRB 1, 1500 W. Medical Center Drive, Ann Arbor, MI 48109, USA. FAU - Chovatiya, Jasmin AU - Chovatiya J AUID- ORCID: 0009-0007-9925-7795 AD - Institute for Exposomic Research, Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Jagani, Ravikumar AU - Jagani R AUID- ORCID: 0000-0002-7680-860X AD - Institute for Exposomic Research, Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Andra, Syam S AU - Andra SS AUID- ORCID: 0000-0003-2839-6417 AD - Institute for Exposomic Research, Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. FAU - Padmanabhan, Vasantha AU - Padmanabhan V AUID- ORCID: 0000-0002-8443-7212 AD - Department of Pediatrics, University of Michigan, 7510 MSRB 1, 1500 W. Medical Center Drive, Ann Arbor, MI 48109, USA. LA - eng GR - Institutional Funding from the Department of Pediatrics/University of Michigan/ PT - Journal Article DEP - 20260512 PL - Switzerland TA - Toxics JT - Toxics JID - 101639637 PMC - PMC13211517 OTO - NOTNLM OT - exposome OT - glucocorticoids OT - maternal BMI OT - oxidative stress OT - pregnancy COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:40 MHDA- 2026/05/27 06:41 PMCR- 2026/05/12 CRDT- 2026/05/27 01:24 PHST- 2026/04/13 00:00 [received] PHST- 2026/05/05 00:00 [revised] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/05/27 06:41 [medline] PHST- 2026/05/27 06:40 [pubmed] PHST- 2026/05/27 01:24 [entrez] PHST- 2026/05/12 00:00 [pmc-release] AID - toxics14050421 [pii] AID - toxics-14-00421 [pii] AID - 10.3390/toxics14050421 [doi] PST - epublish SO - Toxics. 2026 May 12;14(5):421. doi: 10.3390/toxics14050421. PMID- 42198440 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 1424-8247 (Print) IS - 1424-8247 (Electronic) IS - 1424-8247 (Linking) VI - 19 IP - 5 DP - 2026 May 13 TI - Dosing Strategies for High-Alert Medications in Obese Pediatric Patients: A Systematic Review. LID - 10.3390/ph19050766 [doi] LID - 766 AB - Background/Objective: Childhood obesity induces physiological changes that alter drug distribution and clearance; however, these patients are often excluded from clinical trials, creating a critical safety gap for high-alert medications (HAM). The Objective was to evaluate HAM dosing strategies and pharmacokinetic (PK) alterations in overweight and obese pediatric patients. Methods: A systematic review was conducted and registered in PROSPERO (CRD42023452126). A search of MEDLINE, EMBASE, Web of Science, and Cochrane CENTRAL (1990-March 2026) identified studies reporting dosing strategies or PK of HAM in obese or overweight pediatric patients. Studies were included if they reported dosing recommendations or PK parameters. Eligible designs comprised prospective and retrospective, randomized and non-randomized, observational (cohort, case-control, and cross-sectional), case series, case reports, and narrative and systematic reviews. Study selection, data extraction, and quality assessment were conducted independently by two reviewers. Methodological quality was assessed using validated tools, and results were synthesized qualitatively. Results: Of 5801 records, 91 studies were included, providing evidence for only 27% of the evaluated HAM. Total body weight (TBW) appeared to be appropriate for insulin and vancomycin, although close monitoring was required. TBW-based dosing was associated with approximately 20% overexposure for enoxaparin, supporting the use of fat-free mass (FFM) or reduced dosing strategies. Increased clearance may justify higher doses for amlodipine and consideration of adult-equivalent dosing for metformin in adolescents. For gentamicin, FFM appeared to be the most appropriate descriptor, while adjusted body weight was used for valproic acid. In anesthetics and sedatives, reduced TBW-based dosing may be considered for propofol, whereas ideal body weight (IBW) or FFM were generally preferred for ketamine and dexmedetomidine. Analgesics such as fentanyl and morphine may require IBW- or FFM-based dosing, and maintenance dosing of paracetamol may require adjustment. Conclusions: Evidence remains limited and heterogeneous, with no standardized dosing approach. Model-informed strategies-such as population PK (PopPK) and physiologically based PK model (PBPK) approaches-may be useful for hypothesis generation and exploring PK variability; however, their clinical applicability is constrained by the limited and heterogeneous evidence base, and they should be considered exploratory. FAU - Hernandez-Gago, Yolanda AU - Hernandez-Gago Y AUID- ORCID: 0000-0001-5074-8728 AD - Department of Hospital Pharmacy, Insular Maternal and Child University Hospital Complex, 35016 Las Palmas de Gran Canaria, Spain. FAU - Minagorre, Pedro J Alcala AU - Minagorre PJA AUID- ORCID: 0000-0003-4737-5638 AD - Department of Pediatric, Dr. Balmis University General Hospital, Alicante Institute for Health and Biomedical Research (ISABIAL), 03010 Alicante, Spain. FAU - Sanchez-Hernandez, Jose German AU - Sanchez-Hernandez JG AUID- ORCID: 0000-0002-2985-3686 AD - Department of Hospital Pharmacy, University Hospital of Salamanca, 37007 Salamanca, Spain. FAU - Marrodan, Belen Rodriguez AU - Marrodan BR AD - Department of Hospital Pharmacy, Puerta de Hierro University Hospital, 28222 Majadahonda, Spain. FAU - Hernandez Sabater, Laura AU - Hernandez Sabater L AD - Department of Pediatric, Northwest Regional Hospital, 30400 Caravaca de la Cruz, Spain. FAU - Negrin, Ana Cristina Rodriguez AU - Negrin ACR AD - Department of Hospital Pharmacy, Insular Maternal and Child University Hospital Complex, 35016 Las Palmas de Gran Canaria, Spain. FAU - Rodriguez-Suarez, Claudio-Alberto AU - Rodriguez-Suarez CA AUID- ORCID: 0000-0001-6226-7374 AD - Research Support Department, Insular Maternal and Child University Hospital Complex, 35016 Las Palmas de Gran Canaria, Spain. AD - Nursing Department, Faculty of Healthcare Science, University of Las Palmas de Gran Canaria (ULPGC), 35016 Las Palmas de Gran Canaria, Spain. CN - Research Group on High-Alert Medication Dosing in Obese Pediatric Patients, Spanish Society of Hospital Pharmacy (SEFH) and The Spanish Society of Hospital Pediatric Internal Medicine (SEPIH) LA - eng GR - No grant number is associated with this study/The Spanish Foundation of Hospital Pharmacy (FEFH)/ PT - Journal Article PT - Review DEP - 20260513 PL - Switzerland TA - Pharmaceuticals (Basel) JT - Pharmaceuticals (Basel, Switzerland) JID - 101238453 PMC - PMC13209847 OTO - NOTNLM OT - body size descriptors OT - dose adjustment OT - drug safety OT - high-alert medications OT - pediatric obesity OT - pharmacokinetics OT - therapeutic drug monitoring COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:39 MHDA- 2026/05/27 06:40 PMCR- 2026/05/13 CRDT- 2026/05/27 01:24 PHST- 2026/04/11 00:00 [received] PHST- 2026/05/07 00:00 [revised] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/05/27 06:40 [medline] PHST- 2026/05/27 06:39 [pubmed] PHST- 2026/05/27 01:24 [entrez] PHST- 2026/05/13 00:00 [pmc-release] AID - ph19050766 [pii] AID - pharmaceuticals-19-00766 [pii] AID - 10.3390/ph19050766 [doi] PST - epublish SO - Pharmaceuticals (Basel). 2026 May 13;19(5):766. doi: 10.3390/ph19050766. PMID- 42197860 OWN - NLM STAT- MEDLINE DCOM- 20260601 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 10 DP - 2026 May 12 TI - Prediction of Center-of-Mass Kinematics of Sensopro Exercises with Neural Network Models. LID - 10.3390/s26103051 [doi] LID - 3051 AB - Monitoring center-of-mass is crucial for assessing postural control, but field measurements are often impractical or cost-prohibitive. This study investigates the feasibility of predicting center-of-mass kinematics from the motion of an unstable base-the Sensopro Luna-using deep learning, eliminating the need for wearable sensors. We conducted a cross-sectional study in which 64 participants were recorded performing three coordination exercises (Single-Leg Stance, Stepping, and Waves). Marker-based motion capture and auxiliary inertial sensors were used to record reference and tape kinematics. The model inputs consisted of IMU- and motion-capture-derived tape segment orientations, IMU accelerations and angular velocities, and algorithmic estimates of the lowest tape positions. Nine axis-specific exercise models were developed using a hybrid Encoder-LSTM-Decoder architecture and compared against linear regression baselines. Our results indicate that the deep learning models successfully predicted horizontal center-of-mass displacements (DNN Mean Absolute Errors of 16.1-23.7 mm for X-axis and 4.4-31.3 mm for Y-axis) and exhibited descriptively lower errors than linear models in mean absolute error and signal morphology. However, vertical predictions were less reliable, likely due to the physical constraints inherent to the kinematics of the unstable base. Error analysis revealed that prediction accuracy was highest within common postural ranges, but decreased for extreme displacements. These findings provide a proof-of-concept for wearable-free postural monitoring, particularly for movement along the mediolateral and sagittal axes. Such a system could facilitate automated, cost-effective postural feedback and performance tracking in rehabilitation and fitness environments, supporting autonomous coordination training without the practical constraints of traditional measurement systems. FAU - Hegi, Heinz AU - Hegi H AUID- ORCID: 0000-0001-8230-5251 AD - Institute of Sport Science, University of Bern, 3012 Bern, Switzerland. FAU - Single, Michael AU - Single M AUID- ORCID: 0000-0002-4883-9484 AD - Gerontechnology and Rehabilitation Group, ARTORG Center for Biomedical Engineering Research, University of Bern, 3010 Bern, Switzerland. FAU - Nef, Tobias AU - Nef T AUID- ORCID: 0000-0002-8069-9450 AD - Gerontechnology and Rehabilitation Group, ARTORG Center for Biomedical Engineering Research, University of Bern, 3010 Bern, Switzerland. FAU - Kredel, Ralf AU - Kredel R AUID- ORCID: 0000-0001-6279-8132 AD - Institute of Sport Science, University of Bern, 3012 Bern, Switzerland. LA - eng GR - 38795.1 IP-LS/Innosuisse - Swiss Innovation Agency/ PT - Journal Article DEP - 20260512 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - *Biomechanical Phenomena MH - Neural Networks, Computer MH - Computer Simulation MH - Deep Learning MH - Cross-Sectional Studies MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Motion Capture MH - Postural Balance MH - *Exercise MH - Walking PMC - PMC13211100 OTO - NOTNLM OT - center of mass OT - coordination training OT - deep learning OT - time-series analysis COIS- This study was funded as part of an InnoSuisse project with Sensopro AG. Since Innosuisse projects have the explicit goal of promoting science-based innovations, the authors were in contact with and advised by representatives of Sensopro AG during the planning phase of the study, which specifically affected the choice of included exercises. The funders had no role in the collection, analysis, or interpretation of the data. The authors have no relevant financial or non-financial interests to disclose. EDAT- 2026/05/27 06:43 MHDA- 2026/05/27 06:44 PMCR- 2026/05/12 CRDT- 2026/05/27 01:22 PHST- 2026/04/03 00:00 [received] PHST- 2026/05/01 00:00 [revised] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/05/27 06:44 [medline] PHST- 2026/05/27 06:43 [pubmed] PHST- 2026/05/27 01:22 [entrez] PHST- 2026/05/12 00:00 [pmc-release] AID - s26103051 [pii] AID - sensors-26-03051 [pii] AID - 10.3390/s26103051 [doi] PST - epublish SO - Sensors (Basel). 2026 May 12;26(10):3051. doi: 10.3390/s26103051. PMID- 42197085 OWN - NLM STAT- MEDLINE DCOM- 20260527 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 10 DP - 2026 May 20 TI - Dietary Carbohydrates and ADHD Symptoms: A Systematic Review. LID - 10.3390/nu18101625 [doi] LID - 1625 AB - BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental condition with psychosocial impact. Dietary carbohydrates, particularly added sugars, refined starches, and high-glycemic index/load (GI/GL) patterns, have been proposed as modifiable exposures that may relate to attention and behavioral regulation. This systematic review synthesized evidence linking carbohydrate quantity and quality to ADHD-related outcomes. METHODS: Following PRISMA 2020, PubMed, Scopus, and Web of Science were searched for English-language studies published from January 2015 to December 2025. Eligible studies included observational and interventional designs in children, adolescents, or adults with a clinical ADHD diagnosis or validated symptom assessment. Risk of bias was assessed using NOS/NOS-adapted criteria, RoB 2, and ROBINS-I. Findings were synthesized narratively by exposure domain. RESULTS: Of 1174 records identified, 48 studies were included: 38 observational and 10 interventional. Sugar-related exposures showed the most consistent pattern: 15 of 16 studies examining added sugars, sugar-sweetened beverages, sweets, candy, or sweet dietary patterns reported positive associations with ADHD diagnosis, symptom severity, hyperactivity, or less favorable ADHD-related outcomes. Findings for total carbohydrate intake were inconsistent. GI/GL-specific evidence was limited but generally adverse in direction. Among intervention studies, symptom improvement after modification was reported in 6 of 10 studies, whereas 4 studies showed mixed, preliminary, non-significant, or non-superior findings. Most observational studies showed moderate to high risk of bias, while interventional studies showed variable risk across domains. CONCLUSIONS: Poorer carbohydrate quality may be associated with greater ADHD-related symptom burden, whereas total carbohydrate intake showed inconsistent associations. Certainty remains limited by heterogeneity, residual confounding, risk of bias, and limited carbohydrate-specific intervention evidence. FAU - Panayotova, Gabriela Georgieva AU - Panayotova GG AUID- ORCID: 0000-0003-1404-8884 AD - Division of Physiology, Department of Physiology and Pathophysiology, Medical University of Varna, 9002 Varna, Bulgaria. FAU - Hachmeriyan, Antoniya AU - Hachmeriyan A AUID- ORCID: 0000-0003-1275-876X AD - Division of Physiology, Department of Physiology and Pathophysiology, Medical University of Varna, 9002 Varna, Bulgaria. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260520 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Dietary Carbohydrates) SB - IM MH - Adolescent MH - Adult MH - Child MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/etiology MH - *Dietary Carbohydrates/adverse effects/administration & dosage MH - Glycemic Index MH - Glycemic Load PMC - PMC13209895 OTO - NOTNLM OT - ADHD OT - added sugars OT - dietary carbohydrates OT - glycemic index OT - glycemic load OT - systematic review COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:41 MHDA- 2026/05/27 06:42 PMCR- 2026/05/20 CRDT- 2026/05/27 01:19 PHST- 2026/04/09 00:00 [received] PHST- 2026/05/16 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/05/27 06:42 [medline] PHST- 2026/05/27 06:41 [pubmed] PHST- 2026/05/27 01:19 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - nu18101625 [pii] AID - nutrients-18-01625 [pii] AID - 10.3390/nu18101625 [doi] PST - epublish SO - Nutrients. 2026 May 20;18(10):1625. doi: 10.3390/nu18101625. PMID- 42197082 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 10 DP - 2026 May 20 TI - Development and Construct Validation of a Food-Based Diet Quality Score Using Image-Based Food Records. LID - 10.3390/nu18101622 [doi] LID - 1622 AB - Background/Objectives: Diet quality indices (DQIs) are commonly used to evaluate the alignment of dietary intake with national dietary guidelines. However, few methods have been developed to apply DQIs to image-based dietary assessment tools. This study aimed to develop a novel food-based Diet Quality Score (DQS) and examine its construct validity in Australian adults aged 18-65 years living with a higher weight (BMI 30-45 kg/m(2)), using the validated Healthy Eating Index for Australians 2013 (HEIFA-2013) for comparison. Methods: This cross-sectional study assessed dietary intake in 260 adults (mean age 48 +/- 12 years; BMI 35.0 +/- 4.2) collected over 4 days using the mobile Food Record (mFR) and scored using the HEIFA-2013 and DQS (both scored out of 100). Descriptive statistics summarised participant characteristics with DQS and HEIFA-2013 scores. Construct validity was examined by assessing the associations between sociodemographic, health behaviour, anthropometric, and clinical blood marker variables and DQS and HEIFA-2013 scores. Multivariable binary logistic regression identified variables associated with being in the lowest diet quality tertile for both DQIs. Results: The mean scores were 47.4 +/- 8.7 for the DQS and 52.0 +/- 8.6 for HEIFA-2013. Both scores were positively associated with age (DQS: r = 0.216, p < 0.001; HEIFA-2013: r = 0.265, p < 0.001) and attention paid to the health aspects of their diet (DQS: p < 0.023; HEIFA-2013: p < 0.010). Increasing age (OR = 0.958, 95% CI: 0.932-0.985, p = 0.003) and moderate versus low physical activity (OR = 0.40, 95% CI: 0.21-0.80, p = 0.009) decreased odds of being in the lowest diet quality tertile for both DQI scores. Conclusions: The DQS demonstrated acceptable construct validity, providing a valid method for using image-based dietary assessments to evaluate diet quality in Australian populations. FAU - Hassan, Amira AU - Hassan A AUID- ORCID: 0000-0001-7563-2457 AD - Curtin School of Population Health, Curtin University, Perth, WA 6102, Australia. AD - Curtin Medical Research Institute, Curtin University, Perth, WA 6102, Australia. FAU - Dhaliwal, Satvinder S AU - Dhaliwal SS AD - Curtin School of Population Health, Curtin University, Perth, WA 6102, Australia. AD - Office of the Provost, Singapore University of Social Sciences, 463 Clementi Road, Singapore 599494, Singapore. AD - Health & Social Sciences, Singapore Institute of Technology, 1 Punggol Coast Road, Singapore 828608, Singapore. AD - Obstetrics & Gynaecology Academic Clinical Program, Duke NUS Medical School, National University of Singapore, 8 College Road, Singapore 169857, Singapore. FAU - Pollard, Christina M AU - Pollard CM AUID- ORCID: 0000-0003-4261-4601 AD - Curtin School of Population Health, Curtin University, Perth, WA 6102, Australia. AD - Curtin Medical Research Institute, Curtin University, Perth, WA 6102, Australia. AD - Enable Institute, Faculty of Health Sciences, Curtin University, Perth, WA 6102, Australia. FAU - Begley, Andrea AU - Begley A AUID- ORCID: 0000-0002-5448-8932 AD - Curtin School of Population Health, Curtin University, Perth, WA 6102, Australia. AD - Curtin Medical Research Institute, Curtin University, Perth, WA 6102, Australia. FAU - James, Anthony P AU - James AP AUID- ORCID: 0000-0002-0873-3714 AD - Curtin School of Population Health, Curtin University, Perth, WA 6102, Australia. AD - Curtin Medical Research Institute, Curtin University, Perth, WA 6102, Australia. FAU - Roy, Rajshri AU - Roy R AUID- ORCID: 0000-0002-7939-1790 AD - Discipline of Nutrition and Dietetics, Susan Wakil School of Nursing and Midwifery, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW 2006, Australia. AD - Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia. FAU - Legrand, Samara AU - Legrand S AD - Department of Nutrition, Dietetics and Food, Monash University, Melbourne, VIC 3168, Australia. FAU - McCaffrey, Tracy A AU - McCaffrey TA AUID- ORCID: 0000-0001-9699-3083 AD - Department of Nutrition, Dietetics and Food, Monash University, Melbourne, VIC 3168, Australia. FAU - Kerr, Deborah A AU - Kerr DA AUID- ORCID: 0000-0002-1094-1299 AD - Curtin School of Population Health, Curtin University, Perth, WA 6102, Australia. AD - Curtin Medical Research Institute, Curtin University, Perth, WA 6102, Australia. LA - eng GR - MRF2006647/National Health and Medical Research Council Medical Research Future Fund/ PT - Journal Article PT - Validation Study DEP - 20260520 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Middle Aged MH - Cross-Sectional Studies MH - Adult MH - *Diet Records MH - Female MH - Male MH - Australia MH - *Diet, Healthy MH - Reproducibility of Results MH - Young Adult MH - *Nutrition Assessment MH - Adolescent MH - Aged MH - *Diet/standards PMC - PMC13209993 OTO - NOTNLM OT - adults OT - construct validity OT - diet quality OT - diet quality score OT - image-based dietary assessment OT - mobile food record COIS- D.A.K. holds 2 patents for the mFR as follows: C. Boushey, E.J. Delp, D.S. Ebert, K.D. Lutes, D. Kerr, "Dietary Assessment System and Method," U.S. Patent 8 605 952 B2, 10 December 2013; C. Boushey, E.J. Delp, D.S. Ebert, K.D. Lutes, D. Kerr, "Dietary Assessment System and Method," U.S. Patent 8 363 913 B2, 29 January 2013. All other authors report no conflicts of interest. EDAT- 2026/05/27 06:32 MHDA- 2026/05/27 06:33 PMCR- 2026/05/20 CRDT- 2026/05/27 01:19 PHST- 2026/01/15 00:00 [received] PHST- 2026/05/08 00:00 [revised] PHST- 2026/05/14 00:00 [accepted] PHST- 2026/05/27 06:33 [medline] PHST- 2026/05/27 06:32 [pubmed] PHST- 2026/05/27 01:19 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - nu18101622 [pii] AID - nutrients-18-01622 [pii] AID - 10.3390/nu18101622 [doi] PST - epublish SO - Nutrients. 2026 May 20;18(10):1622. doi: 10.3390/nu18101622. PMID- 42197077 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 10 DP - 2026 May 20 TI - Ultra-Processed Food Consumption Patterns and Their Association with Blood Pressure Among Young Adults: A Cross-Sectional Study. LID - 10.3390/nu18101617 [doi] LID - 1617 AB - Background: Hypertension is being increasingly observed among young adults in urban India, alongside rapid dietary transitions and rising consumption of ultra-processed foods (UPFs). The current study aimed to assess the frequency and patterns of UPF consumption and examine their association with high blood pressure among urban college students. Methods: A cross-sectional study was conducted among 311 undergraduate students aged 18-24 years from three colleges in Hyderabad, India. Our study used a validated automated device to measure blood pressure. Dietary intake over the previous month was assessed using a 24-item food frequency questionnaire capturing commonly consumed UPFs. After adjusting for age, sex, and socioeconomic variables, multivariable logistic regression was performed to assess the relationships between UPF consumption categories and high blood pressure. Ninety-five percent confidence intervals (CIs) for adjusted odds ratios (AORs) were reported. Results: Overall, 12.5% of participants had high BP (>/=140/90 mmHg). The prevalence was higher among males and those aged >20 years. In the adjusted analyses, males had significantly higher odds of having high BP (AOR: 4.96; 95% CI: 1.64-15.01), as did students from higher-income households (AOR: 3.22; 95% CI: 1.07-9.66). Consumption of high-fat and/or high-salt UPFs at or above the median was independently associated with high BP (AOR: 2.85; 95% CI: 1.16-6.99). Taste, availability, and low cost were common drivers of UPF intake. Conclusions: Higher consumption of high-fat and/or high-salt ultra-processed foods was associated with higher odds of elevated blood pressure among urban young adults. These findings warrant further longitudinal investigation and may help inform the development of targeted dietary awareness and food environment interventions in college settings. FAU - Ramanujam, Karthikeyan AU - Ramanujam K AUID- ORCID: 0000-0002-1970-8696 AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Mahathi, Abhigna AU - Mahathi A AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Pawar, Jarupula Namrathaa AU - Pawar JN AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Matla, Maheshwari AU - Matla M AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Ponnapalli, Harichandana AU - Ponnapalli H AUID- ORCID: 0000-0001-5494-2368 AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Soma, Vinay Kumar AU - Soma VK AUID- ORCID: 0009-0006-5925-658X AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Gajjala, Keerthana AU - Gajjala K AUID- ORCID: 0009-0006-7852-8309 AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Chukkala, SuryaGoud S AU - Chukkala SS AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Mummadi, Mahesh Kumar AU - Mummadi MK AUID- ORCID: 0000-0002-0412-425X AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Gavaravarapu, SubbaRao M AU - Gavaravarapu SM AUID- ORCID: 0000-0003-4524-9646 AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Reddy, G Bhanuprakash AU - Reddy GB AUID- ORCID: 0000-0003-4787-3944 AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Geddam, Jagajeevan Babu AU - Geddam JB AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. FAU - Reddy, Samarasimha Nusi AU - Reddy SN AD - ICMR-National Institute of Nutrition, Hyderabad 500007, India. LA - eng GR - INTR-IG/NIN/02/2023/Indian Council of Medical Research/ PT - Journal Article DEP - 20260520 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Cross-Sectional Studies MH - Female MH - Young Adult MH - Adolescent MH - *Blood Pressure MH - *Hypertension/epidemiology/etiology MH - *Fast Foods/adverse effects MH - India/epidemiology MH - *Feeding Behavior MH - Prevalence MH - Students MH - Odds Ratio MH - Logistic Models MH - Adult MH - *Diet/adverse effects PMC - PMC13209713 OTO - NOTNLM OT - college students OT - hypertension OT - sodium intake OT - ultra-processed foods OT - young adults COIS- The authors declare no competing interests. EDAT- 2026/05/27 06:40 MHDA- 2026/05/27 06:41 PMCR- 2026/05/20 CRDT- 2026/05/27 01:19 PHST- 2026/03/24 00:00 [received] PHST- 2026/04/15 00:00 [revised] PHST- 2026/04/23 00:00 [accepted] PHST- 2026/05/27 06:41 [medline] PHST- 2026/05/27 06:40 [pubmed] PHST- 2026/05/27 01:19 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - nu18101617 [pii] AID - nutrients-18-01617 [pii] AID - 10.3390/nu18101617 [doi] PST - epublish SO - Nutrients. 2026 May 20;18(10):1617. doi: 10.3390/nu18101617. PMID- 42197074 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 10 DP - 2026 May 20 TI - Update on Vitamin D Status and Seasonal Variation in a Non-Supplemented Population Living in a High Polluted Urban Area-A Cross-Sectional Study. LID - 10.3390/nu18101614 [doi] LID - 1614 AB - Background: Serum concentrations of 25-hydroxyvitamin D [25(OH)D] are associated with the risk of several chronic and acute diseases. However, updated data on vitamin D status in Mediterranean countries, including Italy, remain limited, hindering effective public health strategies. Objective: To assess serum 25(OH)D levels and their seasonal variation in healthy blood donors aged 18-65 years living in Northern Italy and not taking vitamin D supplements. Given the latitude and the high levels of environmental pollution, cutaneous vitamin D synthesis may be impaired in this population. Recent Italian guidelines on supplementation emphasize the need for updated data on the prevalence of hypovitaminosis D and seasonal variation in endogenous vitamin D synthesis. Methods: In this exploratory retrospective cross-sectional study, 534 blood donors (268 men and 266 women) attending the Transfusion Medicine Unit of the Verona University Hospital were enrolled between April 2016 and May 2018. Serum 25(OH)D concentrations were analyzed by season. Clinical, lifestyle, pharmacological and dietary characteristics were also collected. Results: Among healthy, normal-weight individuals, the prevalence of vitamin D insufficiency (25(OH)D < 50 nmol/L) was low and limited to one-two months per year. Overweight and obesity significantly reduced the likelihood of achieving adequate 25(OH)D levels through cutaneous synthesis for several months. Mean 25(OH)D concentrations were higher than those previously reported in the same area, while seasonal variation remained preserved. Conclusions: In a relatively small non-supplemented population of blood donors living in a high polluted urban area of Northern Italy, seasonal vitamin D synthesis seems to be preserved. These updated data show higher 25(OH)D levels compared to past findings. Although these data certainly warrant further validation through a national survey involving other regions of Italy and in not selected population, they appear to be in line with the SIOMMMS recommendations against indiscriminate serum 25(OH)D testing and against routine supplementation for healthy normal-weight individuals under 70 years. FAU - Bertoldo, Francesco AU - Bertoldo F AUID- ORCID: 0000-0002-5175-7340 AD - Unit of Internal Medicine D, Department of Medicine, University of Verona, 37124 Verona, Italy. FAU - Bortolus, Renata AU - Bortolus R AUID- ORCID: 0000-0003-3857-4133 AD - Office for Research Promotion, Azienda Ospedaliera Universitaria Integrata AOUI Verona, 37126 Verona, Italy. FAU - Filippini, Francesca AU - Filippini F AUID- ORCID: 0000-0001-5884-8635 AD - Office for Research Promotion, Azienda Ospedaliera Universitaria Integrata AOUI Verona, 37126 Verona, Italy. FAU - Chiaffarino, Francesca AU - Chiaffarino F AUID- ORCID: 0000-0001-6009-8108 AD - Gynaecology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Ospedale Maggiore Policlinico, 20122 Milan, Italy. FAU - Udali, Silvia AU - Udali S AUID- ORCID: 0000-0003-1259-497X AD - Unit of Internal Medicine B, "Epigenomics and Gene-Nutrient Interactions" Laboratory, Department of Medicine, University of Verona, 37124 Verona, Italy. FAU - Rizzi, Monica AU - Rizzi M AD - Unit of Transfusion Medicine, Azienda Ospedaliera Universitaria Integrata AOUI Verona, 37126 Verona, Italy. FAU - Montemezzi, Rachele AU - Montemezzi R AD - Unit of Transfusion Medicine, Azienda Ospedaliera Universitaria Integrata AOUI Verona, 37126 Verona, Italy. FAU - Gandini, Giorgio AU - Gandini G AUID- ORCID: 0000-0002-5574-0714 AD - Unit of Transfusion Medicine, Azienda Ospedaliera Universitaria Integrata AOUI Verona, 37126 Verona, Italy. FAU - Montagnana, Martina AU - Montagnana M AUID- ORCID: 0000-0001-8999-0001 AD - Department of Medicine-DIMED, University of Padua, 35122 Padua, Italy. FAU - Lippi, Giuseppe AU - Lippi G AUID- ORCID: 0000-0001-9523-9054 AD - Section of Clinical Biochemistry, Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, 37124 Verona, Italy. FAU - Moruzzi, Sara AU - Moruzzi S AUID- ORCID: 0009-0009-5016-1113 AD - Unit of Internal Medicine B, "Epigenomics and Gene-Nutrient Interactions" Laboratory, Department of Medicine, University of Verona, 37124 Verona, Italy. FAU - Parazzini, Fabio AU - Parazzini F AUID- ORCID: 0000-0001-5624-4854 AD - Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, 20122 Milan, Italy. FAU - Martinelli, Nicola AU - Martinelli N AUID- ORCID: 0000-0001-6465-5119 AD - Unit of Internal Medicine B, "Epigenomics and Gene-Nutrient Interactions" Laboratory, Department of Medicine, University of Verona, 37124 Verona, Italy. FAU - Lombini, Matteo AU - Lombini M AUID- ORCID: 0000-0001-5813-0391 AD - Unit of Internal Medicine D, Department of Medicine, University of Verona, 37124 Verona, Italy. FAU - De Marchi, Sergio AU - De Marchi S AUID- ORCID: 0000-0001-5775-9614 AD - Unit of Angiology, Department of Medicine, University of Verona, 37124 Verona, Italy. FAU - Pizzolo, Francesca AU - Pizzolo F AUID- ORCID: 0000-0003-4419-3994 AD - Unit of Internal Medicine B, "Epigenomics and Gene-Nutrient Interactions" Laboratory, Department of Medicine, University of Verona, 37124 Verona, Italy. FAU - Friso, Simonetta AU - Friso S AUID- ORCID: 0000-0002-9606-6711 AD - Unit of Internal Medicine B, "Epigenomics and Gene-Nutrient Interactions" Laboratory, Department of Medicine, University of Verona, 37124 Verona, Italy. LA - eng GR - 5587/Bayer (Italy)/ PT - Journal Article DEP - 20260520 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Humans MH - *Seasons MH - Male MH - Cross-Sectional Studies MH - Adult MH - Female MH - Middle Aged MH - *Vitamin D/blood/analogs & derivatives MH - Italy/epidemiology MH - *Vitamin D Deficiency/epidemiology/blood MH - Young Adult MH - Adolescent MH - Retrospective Studies MH - Aged MH - *Urban Population MH - Prevalence MH - *Nutritional Status MH - *Environmental Pollution/adverse effects MH - Blood Donors PMC - PMC13210335 OTO - NOTNLM OT - Italy OT - air pollution OT - seasonality OT - serum sample OT - vitamin D COIS- The authors declare no conflicts of interest. The authors declare that this study received funding from Bayer S.p.A. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/05/27 06:35 MHDA- 2026/05/27 06:36 PMCR- 2026/05/20 CRDT- 2026/05/27 01:19 PHST- 2026/03/31 00:00 [received] PHST- 2026/05/11 00:00 [revised] PHST- 2026/05/13 00:00 [accepted] PHST- 2026/05/27 06:36 [medline] PHST- 2026/05/27 06:35 [pubmed] PHST- 2026/05/27 01:19 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - nu18101614 [pii] AID - nutrients-18-01614 [pii] AID - 10.3390/nu18101614 [doi] PST - epublish SO - Nutrients. 2026 May 20;18(10):1614. doi: 10.3390/nu18101614. PMID- 42197048 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 10 DP - 2026 May 16 TI - Eating Disorder Risk and Its Biobehavioural Correlates in Italian University Students: The UniFoodWaste Study. LID - 10.3390/nu18101588 [doi] LID - 1588 AB - Background/Objectives: To assess the prevalence of eating disorder (ED) risk in a sample of Italian university students and to examine its independent associations with mental health indicators, self-rated health, body mass index (BMI), lifestyle behaviours, and engagement with digital food-related applications. Methods: Of the 2779 Italian university students who accessed the survey, 2691 completed and were included in the analysis. ED risk was assessed with the validated 5-item SCOFF questionnaire. Exposure included socio-demographics, BMI, depressive symptoms (PHQ-9), self-rated health, adherence to the Mediterranean diet (Medi-Lite), smoking, alcohol use (AUDIT-C), and use of food delivery and food waste apps. Multivariable logistic regression models, stratified by sex, and adjusted by age and education, estimated associations with ED risk. Results: Overall, 34.6% of participants screened positive for ED risk (women 39.5%, men 21.8%). Smoking and use of food delivery apps and food waste apps were independently associated with ED risk. Clinically relevant depressive symptoms (PHQ-9 >/= 10) (aOR 3.37, 95% CI 2.82-4.02) and poor/fair self-rated health (aOR 2.45, 95% CI 1.93-3.11) showed the strongest association. Overweight (aOR 1.47, 95% CI 1.06-2.03) and obesity (aOR 2.48, 95% CI 1.53-4.01) increased the likelihood of ED risk. Risky alcohol use was also associated (aOR 1.42, 95% CI 1.15-1.75). Conclusions: More than one in three Italian university students is at risk for an ED, highlighting a substantial public health concern. Strong links with depression, perceived poor health, digital food app use, and unhealthy behaviours underscore the need for early screening and integrated mental health and nutrition interventions within university settings. FAU - Pennisi, Flavia AU - Pennisi F AUID- ORCID: 0009-0001-9185-9747 AD - Faculty of Medicine, University Vita-Salute San Raffaele, 20132 Milan, Italy. AD - PhD National Program in One Health Approaches to Infectious Diseases and Life Science Research Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Pinto, Antonio AU - Pinto A AUID- ORCID: 0009-0006-4315-0481 AD - Faculty of Medicine, University Vita-Salute San Raffaele, 20132 Milan, Italy. FAU - Nucci, Daniele AU - Nucci D AUID- ORCID: 0000-0003-4546-213X AD - PhD National Program in One Health Approaches to Infectious Diseases and Life Science Research Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. AD - Struttura Semplice Dipartimentale Igiene Alimenti e Nutrizione, Dipartimento di Igiene e Prevenzione Sanitaria, Agenzia di Tutela Della Salute (ATS) Brescia, Via Duca Degli Abruzzi, 15, 25124 Brescia, Italy. FAU - Stacchini, Lorenzo AU - Stacchini L AUID- ORCID: 0000-0002-7405-4904 AD - Department of Community Healthcare Network, Health District "Toscana ASL Nord Ovest", Pisa, Via Fleming 1, 56025 Pontedera, Italy. FAU - Garzitto, Marco AU - Garzitto M AUID- ORCID: 0000-0001-7565-420X AD - Unit of Psychiatry, Department of Medicine (DMED), University of Udine, 33100 Udine, Italy. FAU - Veronese, Nicola AU - Veronese N AUID- ORCID: 0000-0002-9328-289X AD - Faculty of Medicine, Saint Camillus International University of Health Sciences, 00131 Rome, Italy. FAU - Maggi, Stefania AU - Maggi S AUID- ORCID: 0000-0002-0453-8663 AD - Institute of Neuroscience, Aging Unit, National Research Council, 35127 Padova, Italy. FAU - Signorelli, Carlo AU - Signorelli C AUID- ORCID: 0000-0002-0960-9563 AD - Faculty of Medicine, University Vita-Salute San Raffaele, 20132 Milan, Italy. FAU - Baldo, Vincenzo AU - Baldo V AUID- ORCID: 0000-0001-6012-9453 AD - Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy. FAU - Colizzi, Marco AU - Colizzi M AUID- ORCID: 0000-0001-6139-1920 AD - Unit of Psychiatry, Department of Medicine (DMED), University of Udine, 33100 Udine, Italy. AD - Department of Psychosis Studies, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London SE5 8AF, UK. FAU - Gianfredi, Vincenza AU - Gianfredi V AUID- ORCID: 0000-0003-3848-981X AD - Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padua, 35128 Padua, Italy. LA - eng GR - PSR-LINEA2-2022/University of Milan/ PT - Journal Article DEP - 20260516 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Italy/epidemiology MH - Male MH - *Students/psychology/statistics & numerical data MH - Universities MH - Young Adult MH - Risk Factors MH - *Feeding and Eating Disorders/epidemiology/psychology MH - Adult MH - Adolescent MH - Prevalence MH - Surveys and Questionnaires MH - Depression/epidemiology MH - Body Mass Index MH - Life Style MH - Cross-Sectional Studies MH - Mental Health PMC - PMC13209805 OTO - NOTNLM OT - Italy OT - digital food environment OT - eating disorders OT - lifestyle factors OT - mental health OT - university students COIS- The authors declare the following financial interests/personal relationships, which may be considered as potential competing interests: Marco Colizzi reports honoraria from Janssen-Cilag S.p.A. and Epitech Group S.p.A. for scientific communication and outreach activities and has served as a consultant/advisor for GW Pharma Limited, F. Hoffmann-La Roche Limited, GW Pharma Italy S.r.l., Idorsia Pharmaceuticals Italy S.r.l., and Insights Driven Research (IDR); Vincenza Gianfredi reports that financial support was provided by the University of Milan. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article. EDAT- 2026/05/27 06:38 MHDA- 2026/05/27 06:39 PMCR- 2026/05/16 CRDT- 2026/05/27 01:19 PHST- 2026/04/07 00:00 [received] PHST- 2026/05/07 00:00 [revised] PHST- 2026/05/13 00:00 [accepted] PHST- 2026/05/27 06:39 [medline] PHST- 2026/05/27 06:38 [pubmed] PHST- 2026/05/27 01:19 [entrez] PHST- 2026/05/16 00:00 [pmc-release] AID - nu18101588 [pii] AID - nutrients-18-01588 [pii] AID - 10.3390/nu18101588 [doi] PST - epublish SO - Nutrients. 2026 May 16;18(10):1588. doi: 10.3390/nu18101588. PMID- 42197036 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 10 DP - 2026 May 15 TI - Influence of Parental Lifestyle and Dietary Patterns on Mediterranean Diet Adherence in Children and Adolescents: A Cross-Sectional Study. LID - 10.3390/nu18101576 [doi] LID - 1576 AB - Background/Objectives: Adherence to the Mediterranean diet (MD) is associated with reduced risk of non-communicable diseases but has declined among children, even in traditionally high-adherence settings such as Greece. As parental lifestyle behaviors strongly influence children's dietary patterns, this study examined the associations between parental lifestyle factors and children's MD adherence in Crete, Greece. Methods: A total of 760 parent-child dyads participated in this cross-sectional study. Children's adherence to the MD was assessed using the KIDMED index. Parents completed validated instruments, including the MEDAS (MD adherence), IPAQ (physical activity), PSQI (sleep quality), and NLS (nutrition literacy), along with questions on dietary habits and screen time behaviors. ANOVA/Kruskal-Wallis tests and multivariable linear regression identified predictors of KIDMED scores. Results: Mean KIDMED score was 5.95 +/- 2.65; 32% achieved optimal adherence. Younger children showed higher adherence. Higher children's adherence to MD was positively associated with parental MD adherence (beta = 0.493), urban residence (beta = 0.544), higher parental education (beta = 0.493), consistent daily meal routines (breakfast and mid-morning and mid-afternoon snacks), higher water intake, and fresh juice consumption (all p < 0.05) were positively associated with parental MD adherence. Conversely, lower adherence was associated with parental age >/= 45 years (beta = 0.987), higher parental BMI (beta = 0.072), consumption of sugar-sweetened (beta = 0.390) or artificially sweetened beverages (beta = 0.497), and weekend screen time >/= 3 h/day (beta = 0.383) (all p < 0.05). Conclusions: Children's adherence to the MD is strongly associated with parental dietary behaviors and structured meal routines. These findings support family-focused interventions that emphasize parental dietary role modeling to counter declining MD adherence among Mediterranean youth. FAU - Peraki, Sevasti AU - Peraki S AUID- ORCID: 0009-0004-1516-7126 AD - Department of Social Medicine, School of Medicine, University of Crete, 71500 Heraklion, Greece. FAU - Bouloukaki, Izolde AU - Bouloukaki I AUID- ORCID: 0000-0001-5903-3550 AD - Department of Social Medicine, School of Medicine, University of Crete, 71500 Heraklion, Greece. FAU - Christodoulakis, Antonios AU - Christodoulakis A AUID- ORCID: 0000-0003-0544-851X AD - Department of Social Medicine, School of Medicine, University of Crete, 71500 Heraklion, Greece. FAU - Vavoulas, Dimitrios AU - Vavoulas D AUID- ORCID: 0009-0007-3077-1585 AD - Department of Social Medicine, School of Medicine, University of Crete, 71500 Heraklion, Greece. FAU - Tsiligianni, Ioanna AU - Tsiligianni I AUID- ORCID: 0000-0001-7922-7491 AD - Department of Social Medicine, School of Medicine, University of Crete, 71500 Heraklion, Greece. AD - Department of Primary Care and Population Health, Medical School, University of Nicosia, 2417 Nicosia, Cyprus. LA - eng PT - Journal Article DEP - 20260515 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Diet, Mediterranean MH - Cross-Sectional Studies MH - Male MH - Female MH - Child MH - Greece MH - *Life Style MH - Adolescent MH - *Parents/psychology MH - *Feeding Behavior MH - Parent-Child Relations MH - *Patient Compliance MH - Child Behavior PMC - PMC13209914 OTO - NOTNLM OT - KIDMED OT - Mediterranean diet OT - adolescents OT - child obesity OT - dietary patterns OT - family environment OT - health behaviors OT - lifestyle behaviors OT - parents OT - pediatric nutrition COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:41 MHDA- 2026/05/27 06:42 PMCR- 2026/05/15 CRDT- 2026/05/27 01:19 PHST- 2026/04/08 00:00 [received] PHST- 2026/05/14 00:00 [revised] PHST- 2026/05/14 00:00 [accepted] PHST- 2026/05/27 06:42 [medline] PHST- 2026/05/27 06:41 [pubmed] PHST- 2026/05/27 01:19 [entrez] PHST- 2026/05/15 00:00 [pmc-release] AID - nu18101576 [pii] AID - nutrients-18-01576 [pii] AID - 10.3390/nu18101576 [doi] PST - epublish SO - Nutrients. 2026 May 15;18(10):1576. doi: 10.3390/nu18101576. PMID- 42197001 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 10 DP - 2026 May 13 TI - Early Gut Microbiota and Neurodevelopmental Trajectories: Implications for Pediatric Neuropsychiatric Vulnerability-A Narrative Review. LID - 10.3390/nu18101541 [doi] LID - 1541 AB - Neurodevelopment is a dynamic and multifactorial process, critical in the early stages of life, involving the formation of neural networks, the establishment of synapses, and the maturation of cognitive, social and emotional circuits. In this context, the gut microbiome emerges as an essential regulator of neurodevelopment, exerting influences through multiple biochemical and immunological mechanisms that define the "gut-brain axis". The microbiota modulates neurodevelopment by regulating neurotransmitters (serotonin, dopamine, GABA), the production of microbial metabolites, including short-chain fatty acids, the modulation of inflammatory cytokines, and vagal signaling to the central nervous system. Recent evidence highlights the role of microbiota in modulating microglia, synaptogenesis, dendritic maturation, and neuronal plasticity, emphasizing how these processes are influenced by microbial activity rather than providing a comprehensive treatise on plasticity itself. Gut microbiota disturbances, or dysbiosis, have been associated with various neuropsychiatric and neurodevelopmental disorders, contributing to cognitive, behavioral, and emotional dysfunctions. This article summarizes, in a narrative manner, the main dysbiosis patterns identified in these disorders and the biological mechanisms by which the microbiome influences neuronal development and function, including immune-neuronal interactions, metabolomic modulation, and neuroendocrine signaling. Finally, emerging directions of intervention aimed at adjusting the microbial profile, such as dietary adjustment, the use of probiotics, prebiotics, symbiotics, and fecal microbiota transplantation, are presented with the aim of positively influencing neurodevelopment and preventing or ameliorating associated dysfunctions. This review emphasizes the need for longitudinal, rigorous, and controlled clinical trials to validate the efficacy of microbiota modulation strategies and to substantiate their integration into individualized pediatric management protocols. FAU - Lupu, Vasile Valeriu AU - Lupu VV AUID- ORCID: 0000-0003-2640-8795 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. FAU - Nedelcu, Alin Horatiu AU - Nedelcu AH AUID- ORCID: 0000-0002-0024-0237 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. FAU - Miron, Ingrith AU - Miron I AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. FAU - Anton, Sorana Caterina AU - Anton SC AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. FAU - Sasaran, Maria Oana AU - Sasaran MO AUID- ORCID: 0000-0001-8156-7460 AD - Department of Pediatrics, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology, 540142 Targu Mures, Romania. FAU - Frasinariu, Otilia Elena AU - Frasinariu OE AUID- ORCID: 0000-0002-5836-1517 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. FAU - Jechel, Elena AU - Jechel E AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. FAU - Bozomitu, Laura Iulia AU - Bozomitu LI AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. FAU - Chisnoiu, Tatiana AU - Chisnoiu T AUID- ORCID: 0000-0002-4996-2484 AD - Department of Pediatrics, Faculty of Medicine, "Ovidius" University, 900470 Constanta, Romania. FAU - Anton, Carmen Rodica AU - Anton CR AUID- ORCID: 0000-0001-7717-1738 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. FAU - Marginean, Cristina Oana AU - Marginean CO AUID- ORCID: 0000-0003-2119-1726 AD - Department of Pediatrics, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology, 540142 Targu Mures, Romania. FAU - Morariu, Ionela Daniela AU - Morariu ID AUID- ORCID: 0000-0002-7083-8197 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. FAU - Mihai, Cristina Maria AU - Mihai CM AUID- ORCID: 0000-0001-8844-0593 AD - Department of Pediatrics, Faculty of Medicine, "Ovidius" University, 900470 Constanta, Romania. FAU - Anton, Emil AU - Anton E AUID- ORCID: 0000-0002-8244-0522 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. FAU - Lupu, Ancuta AU - Lupu A AUID- ORCID: 0000-0001-8147-3632 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. LA - eng PT - Journal Article PT - Review DEP - 20260513 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Prebiotics) SB - IM MH - Humans MH - Neurodevelopment MH - *Gastrointestinal Microbiome/physiology MH - *Neurodevelopmental Disorders/microbiology MH - Dysbiosis/microbiology MH - Child MH - Brain/growth & development MH - Probiotics MH - Prebiotics/administration & dosage MH - Neuronal Plasticity PMC - PMC13209934 OTO - NOTNLM OT - early life programming OT - gut microbiota OT - gut-brain axis OT - neurodevelopment OT - nutrition OT - pediatric neuropsychiatric disorders COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:42 MHDA- 2026/05/27 06:43 PMCR- 2026/05/13 CRDT- 2026/05/27 01:19 PHST- 2026/03/23 00:00 [received] PHST- 2026/05/04 00:00 [revised] PHST- 2026/05/09 00:00 [accepted] PHST- 2026/05/27 06:43 [medline] PHST- 2026/05/27 06:42 [pubmed] PHST- 2026/05/27 01:19 [entrez] PHST- 2026/05/13 00:00 [pmc-release] AID - nu18101541 [pii] AID - nutrients-18-01541 [pii] AID - 10.3390/nu18101541 [doi] PST - epublish SO - Nutrients. 2026 May 13;18(10):1541. doi: 10.3390/nu18101541. PMID- 42196959 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 10 DP - 2026 May 8 TI - Emotional Influences on Eating Behavior and Hunger Awareness Among Generation Z University Students in Greece. LID - 10.3390/nu18101500 [doi] LID - 1500 AB - BACKGROUND: Emotional determinants of eating behavior are increasingly recognized as critical components of behavioral nutrition, particularly among Generation Z, a population characterized by heightened emotional reactivity and rapidly shifting dietary patterns. OBJECTIVES: This cross-sectional study examined the multidimensional structure of emotional influences on eating behavior among 411 university students in Greece and explored which emotional mechanisms are most closely associated with emotional hunger awareness. METHODS: Using the Emotional Influence on Eating Behavior Questionnaire (EIEBQ), four constructs were assessed. Exploratory Factor Analysis supported a refined four-factor structure explaining 63.23% of variance, following the removal of one low-communality item. RESULTS: Participants reported moderate emotional undereating (M = 3.17) and reduced enjoyment of food under emotional distress (M = 3.38), lower reliance on food for emotional overeating (M = 2.86), and high emotional awareness (M = 3.76). Regression analyses, although explaining a small proportion of variance (R(2) = 0.042), indicated that emotional undereating (beta = 0.155, p = 0.017) and emotional overeating (beta = 0.135, p = 0.027) were the most consistent predictors of emotional hunger awareness. CONCLUSIONS: These findings suggest that emotional responses-rather than cognitive appraisal-may play a meaningful role in distinguishing emotional from physical hunger. By providing an initial psychometric evaluation and a behavior-focused framework, this study offers preliminary insights into emotional eating mechanisms among Generation Z university students and contributes to the development of targeted interventions promoting healthier and more sustainable dietary behaviors. FAU - Koliou, Maria P AU - Koliou MP AUID- ORCID: 0009-0009-1751-5629 AD - Laboratory of Food Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. FAU - Karaiskou, Chrysoula AU - Karaiskou C AD - Sidroco Holdings Ltd., Nicosia 1082, Cyprus. FAU - Eleftheriadis, Charalampos AU - Eleftheriadis C AUID- ORCID: 0000-0002-0726-4127 AD - Sidroco Holdings Ltd., Nicosia 1082, Cyprus. FAU - Kontogeorgos, Achilleas AU - Kontogeorgos A AUID- ORCID: 0000-0002-4186-0379 AD - Department of Agriculture, International University of Greece, 57001 Thessaloniki, Greece. FAU - Skalkos, Dimitris AU - Skalkos D AUID- ORCID: 0000-0002-7771-2845 AD - Laboratory of Food Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. LA - eng PT - Journal Article DEP - 20260508 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Greece MH - Female MH - *Students/psychology MH - *Hunger MH - *Feeding Behavior/psychology MH - Universities MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - *Emotions MH - Surveys and Questionnaires MH - Emotional Eating MH - Adult MH - Adolescent MH - Awareness MH - Hyperphagia/psychology PMC - PMC13209663 OTO - NOTNLM OT - Generation Z OT - behavioral nutrition OT - eating behavior OT - emotional awareness OT - emotional eating OT - emotional hunger OT - emotional regulation OT - food enjoyment OT - overeating OT - undereating COIS- C.K. and C.E. were employed by Sidroco Holdings Ltd. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/27 06:34 MHDA- 2026/05/27 06:35 PMCR- 2026/05/08 CRDT- 2026/05/27 01:19 PHST- 2026/04/17 00:00 [received] PHST- 2026/04/30 00:00 [revised] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/05/27 06:35 [medline] PHST- 2026/05/27 06:34 [pubmed] PHST- 2026/05/27 01:19 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - nu18101500 [pii] AID - nutrients-18-01500 [pii] AID - 10.3390/nu18101500 [doi] PST - epublish SO - Nutrients. 2026 May 8;18(10):1500. doi: 10.3390/nu18101500. PMID- 42196723 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 5 DP - 2026 May 10 TI - Feasibility and Acceptability of a School-Based Nutrition Education Toolkit: Findings from an Expert Review. LID - 10.3390/ijerph23050630 [doi] LID - 630 AB - Helping Early Adolescents Live Their Healthiest Youth (HEALTHY) is a theory-driven, school-based nutrition education program grounded in frozen-fruit smoothie taste tests that has been shown to improve fruit intake and promote nutrition security among rural adolescents. To support broader dissemination, a comprehensive implementation toolkit and website were developed. This study conducted an expert review to evaluate the feasibility, clarity, and acceptability of the HEALTHY Toolkit. A survey collected quantitative (Likert-scale) and qualitative (open-ended) data, which were analyzed using descriptive statistics and content analysis. Experts (N = 15) primarily included Registered Dietitians (40%, n = 6) and school nutrition professionals (33%, n = 5). Experts reported high agreement that the HEALTHY Toolkit provided sufficient detail and guidance for implementation, indicating strong feasibility, clarity, and acceptability. Mean scores across Toolkit sections were high: Part I. Foundations (4.70 +/- 0.26), Part II. Program Design and Implementation (4.64 +/- 0.41), and Part III. Tools and Resources (4.14 +/- 0.17). These findings support the use of formative evaluation approaches, such as expert review, to optimize implementation resources and strengthen readiness before dissemination. Overall, the HEALTHY Toolkit was perceived as a promising resource for supporting the implementation of the HEALTHY program. FAU - Sullivan, Amelia AU - Sullivan A AUID- ORCID: 0009-0003-9729-5721 AD - School of Food and Agriculture, University of Maine, Orono, ME 04469, USA. FAU - Kubinsky, Bryn AU - Kubinsky B AUID- ORCID: 0009-0007-8442-7595 AD - School of Food and Agriculture, University of Maine, Orono, ME 04469, USA. FAU - McNamara, Jade AU - McNamara J AD - School of Food and Agriculture, University of Maine, Orono, ME 04469, USA. LA - eng GR - NA/Wyman's Wild Blueberry Research and Innovation Center Fund/ PT - Journal Article DEP - 20260510 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - *Health Education/methods MH - Schools MH - Adolescent MH - Feasibility Studies PMC - PMC13206662 OTO - NOTNLM OT - adolescents OT - expert review OT - implementation resource OT - nutrition education OT - nutrition security OT - rural health OT - school nutrition OT - toolkit COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:39 MHDA- 2026/05/27 06:40 PMCR- 2026/05/10 CRDT- 2026/05/27 01:18 PHST- 2026/04/08 00:00 [received] PHST- 2026/05/07 00:00 [revised] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/05/27 06:40 [medline] PHST- 2026/05/27 06:39 [pubmed] PHST- 2026/05/27 01:18 [entrez] PHST- 2026/05/10 00:00 [pmc-release] AID - ijerph23050630 [pii] AID - ijerph-23-00630 [pii] AID - 10.3390/ijerph23050630 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 May 10;23(5):630. doi: 10.3390/ijerph23050630. PMID- 42195977 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20261019 IS - 2304-8158 (Print) IS - 2304-8158 (Electronic) IS - 2304-8158 (Linking) VI - 15 IP - 10 DP - 2026 May 17 TI - Valorization of Bread Waste Hydrolysates and Plant-Based Nitrogen Sources for Mycoprotein Production by Pleurotus salmoneostramineus. LID - 10.3390/foods15101773 [doi] LID - 1773 AB - Mycoprotein production by Pleurotus salmoneostramineus was evaluated using the bread industry by-products wheat bran hydrolysate (WBH) and stale bread hydrolysate (SBH) as carbon sources, with mung bean protein hydrolysate (MBH) as a nitrogen source, within a circular bioeconomy framework. Enzymatic hydrolysis effectively converted these food industry waste streams into fermentable substrates with complementary nutritional profiles: SBH provided the highest total sugar content (57.53 g/L), while MBH contributed the highest total nitrogen (3.58 g/L) and essential amino acid content (215.05 mg/100 mL). Of 11 WBH:SBH ratio formulations evaluated under static cultivation, WB4 (WBH:SBH 70:30; C/N 27.32:1) was identified as the optimal carbon source formulation, producing the highest biomass (3.46 g/L) and protein content (23.19 g/100 g) after 14 days. Subsequent nitrogen source optimization under dynamic cultivation (200 rpm, 5 days) showed that MBH supplementation at 5 g/L produced the highest biomass (16.59 g/L), protein content (66.71 g/100 g), and absolute protein production (11.07 g/L). The amino acid profile of mycoprotein produced under optimized conditions met or exceeded the FAO/WHO-recommended essential amino acid requirements for older children, adolescents, and adults; the essential amino acid content (354.72 mg/g protein) was comparable to soy protein isolate and exceeded that of wheat gluten. Mycelial morphology shifted from filamentous networks under static conditions to fragmented clump structures under dynamic cultivation with MBH supplementation. These findings indicate the feasibility of producing nutritionally complete mycoprotein from food industry waste streams, with potential applications in plant-based food formulations. FAU - Sawetchayanont, Patchana AU - Sawetchayanont P AD - Division of Biochemical Technology, School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkok 10150, Thailand. FAU - Laohakunjit, Natta AU - Laohakunjit N AUID- ORCID: 0000-0002-2833-6273 AD - Division of Biochemical Technology, School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkok 10150, Thailand. FAU - Uthairatanakij, Apiradee AU - Uthairatanakij A AUID- ORCID: 0000-0003-4623-7241 AD - Division of Postharvest Technology, School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkok 10150, Thailand. FAU - Selamassakul, Orrapun AU - Selamassakul O AUID- ORCID: 0000-0002-3536-0888 AD - Pilot Plant Development and Training Institute, King Mongkut's University of Technology Thonburi, Bangkok 10150, Thailand. FAU - Ratanakanokchai, Kanok AU - Ratanakanokchai K AD - Division of Biochemical Technology, School of Bioresources and Technology, King Mongkut's University of Technology Thonburi, Bangkok 10150, Thailand. FAU - Mekvichitsaeng, Phenjun AU - Mekvichitsaeng P AD - Pilot Plant Development and Training Institute, King Mongkut's University of Technology Thonburi, Bangkok 10150, Thailand. FAU - Vongsawasdi, Punchira AU - Vongsawasdi P AUID- ORCID: 0000-0002-3053-1262 AD - Department of Microbiology, Faculty of Science, King Mongkut's University of Technology Thonburi, Bangkok 10140, Thailand. LA - eng PT - Journal Article DEP - 20260517 PL - Switzerland TA - Foods JT - Foods (Basel, Switzerland) JID - 101670569 PMC - PMC13206093 OTO - NOTNLM OT - bread waste OT - enzymatic hydrolysis OT - mung bean protein OT - submerged fermentation OT - sustainability COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/27 06:33 MHDA- 2026/05/27 06:34 PMCR- 2026/05/17 CRDT- 2026/05/27 01:15 PHST- 2026/04/12 00:00 [received] PHST- 2026/05/05 00:00 [revised] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/05/27 06:34 [medline] PHST- 2026/05/27 06:33 [pubmed] PHST- 2026/05/27 01:15 [entrez] PHST- 2026/05/17 00:00 [pmc-release] AID - foods15101773 [pii] AID - foods-15-01773 [pii] AID - 10.3390/foods15101773 [doi] PST - epublish SO - Foods. 2026 May 17;15(10):1773. doi: 10.3390/foods15101773. PMID- 42195965 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 2304-8158 (Print) IS - 2304-8158 (Electronic) IS - 2304-8158 (Linking) VI - 15 IP - 10 DP - 2026 May 15 TI - Survey of Pesticide Residues in Vegetables in the Albanian Market and Associated Dietary Exposure. LID - 10.3390/foods15101761 [doi] LID - 1761 AB - Vegetables constitute an essential component of the daily diet in Albania; however, they also represent a major pathway of human exposure to pesticide residues. This study investigates the presence of pesticide residues in widely used vegetables, including leafy, fruity, root, and bulb types, and evaluates the potential dietary health risks associated with their consumption. Vegetable samples were analyzed using gas chromatography-tandem mass spectrometry (GC-MS/MS) and liquid chromatography-tandem mass spectrometry (LC-MS/MS), for the presence of 417 pesticide analytes, ensuring high analytical sensitivity and reliability. Pesticide residues were present, with 42 distinct compounds, including metabolites, found in all the analyzed samples. Notably, some of the detected substances are not currently authorized for use as plant protection products, suggesting either environmental persistence or regulatory non-compliance. Exceedances of European Union maximum residue limits (MRLs) were most frequently detected in leafy vegetables (42.31%), followed by fruity vegetables (18.75%), whereas no MRL exceedances were observed in root and bulb vegetables. According to the dietary exposure assessment conducted using European Food Safety Authority Pesticide Residue Intake Model (EFSA PRIMo model v.3.1), chronic dietary exposure to pesticide residues was below the acceptable daily intake (ADI). According to this assessment, the acute exposure exceeded the acute reference dose (ARfD) for several pesticide-vegetable combinations, particularly among children. This highlights the need for ongoing monitoring and better agricultural management techniques to reduce potential health risks related to pesticide residues in vegetables. The study results indicate the need to strengthen national monitoring programs, enforce pesticide regulations more strictly, and promote the wider adoption of integrated pest management strategies to reduce dietary pesticide exposure and protect public health in Albania. FAU - Marku, Elda AU - Marku E AUID- ORCID: 0000-0003-1199-8737 AD - Faculty of Natural Sciences, University of Tirana, 1000 Tirana, Albania. FAU - Likaj, Matilda AU - Likaj M AUID- ORCID: 0009-0000-6105-3964 AD - Faculty of Natural Sciences, University of Tirana, 1000 Tirana, Albania. FAU - Mediu, Ridvana AU - Mediu R AUID- ORCID: 0000-0001-6568-9003 AD - Faculty of Applied Science, University College LOGOS, 1000 Tirana, Albania. FAU - Tahiraj, Jonida AU - Tahiraj J AUID- ORCID: 0000-0002-2539-6430 AD - Faculty of Natural Sciences, University of Tirana, 1000 Tirana, Albania. FAU - Shehu, Sonila AU - Shehu S AD - Faculty of Natural Sciences, University of Tirana, 1000 Tirana, Albania. FAU - Nuro, Aurel AU - Nuro A AD - Faculty of Natural Sciences, University of Tirana, 1000 Tirana, Albania. FAU - Vladi, Vjollca AU - Vladi V AD - Food Safety and Veterinary Institute, 1000 Tirana, Albania. LA - eng GR - Contract number 999_8/2024/The National Agency for Scientific Research and Innovation (NASRI), Albania/ PT - Journal Article DEP - 20260515 PL - Switzerland TA - Foods JT - Foods (Basel, Switzerland) JID - 101670569 PMC - PMC13205158 OTO - NOTNLM OT - Albania OT - acceptable daily intake OT - chromatography-tandem mass spectrometry OT - dietary exposure OT - maximum residue limits OT - multi-residue analysis OT - pesticide OT - vegetables COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:33 MHDA- 2026/05/27 06:34 PMCR- 2026/05/15 CRDT- 2026/05/27 01:15 PHST- 2026/03/23 00:00 [received] PHST- 2026/04/20 00:00 [revised] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/05/27 06:34 [medline] PHST- 2026/05/27 06:33 [pubmed] PHST- 2026/05/27 01:15 [entrez] PHST- 2026/05/15 00:00 [pmc-release] AID - foods15101761 [pii] AID - foods-15-01761 [pii] AID - 10.3390/foods15101761 [doi] PST - epublish SO - Foods. 2026 May 15;15(10):1761. doi: 10.3390/foods15101761. PMID- 42195133 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 62 IP - 5 DP - 2026 May 4 TI - Sleep Quality and Associated Lifestyle Factors Among Medical Students Before and After the COVID-19 Era-A Comparative Study from Romania. LID - 10.3390/medicina62050880 [doi] LID - 880 AB - Background and Objectives: Sleep is a vital psychological function for health and well-being in all age groups, from children to adolescents, to adults and the elderly, and impacts quality of life. This study evaluated temporal changes in sleep quality and lifestyle behaviors among medical students in North-Western Romania (Transylvania) between the COVID-19 pandemic and the post-pandemic period. Materials and Methods: A cross-sectional design was employed involving 709 medical students assessed during the first pandemic wave (2020) and the 2023-2024 academic year. Online questionnaires collected data on demographics, body mass index (BMI), substance use, and physical activity. Sleep quality was measured using the validated Athens Insomnia Scale (AIS), and multiple linear regression was performed to identify predictors of sleep outcomes. Results: Post-pandemic data revealed a significant decline in sleep quality, with female gender and lower academic performance identified as significant predictors of insomnia symptoms (R(2) of 0.258, p < 0.05). While physical activity levels improved significantly in 2024 compared to the confinement period, this was accompanied by increased fast-food consumption and a rise in overweight and obesity rates. Conversely, illicit drug use decreased, and alcohol consumption patterns shifted, characterized by reduced weekly frequency among females but persistent binge drinking episodes. Conclusions: The transition to post-pandemic education yielded mixed health outcomes; while physical activity rebounded, sleep quality and nutritional status deteriorated. These findings highlight the necessity for university-based interventions focusing on sleep hygiene, nutrition, and stress management to support the well-being of medical students. FAU - Nasui, Bogdana Adriana AU - Nasui BA AUID- ORCID: 0000-0001-5682-0225 AD - Department of Community Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. AD - Research Center in Preventive Medicine, Health Promotion and Sustainable Development, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. FAU - Gorgan, Lorena AU - Gorgan L AD - Department of Community Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. FAU - Popescu, Codruta Alina AU - Popescu CA AUID- ORCID: 0000-0002-3691-8871 AD - Department of Human Sciences, Iuliu Hatieganu University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania. FAU - Ciuciuc, Nina AU - Ciuciuc N AUID- ORCID: 0000-0001-5504-7031 AD - Department of Community Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. AD - Research Center in Preventive Medicine, Health Promotion and Sustainable Development, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. FAU - Rosioara, Alexandra-Ioana AU - Rosioara AI AUID- ORCID: 0000-0002-8914-8137 AD - Department of Community Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. AD - Research Center in Preventive Medicine, Health Promotion and Sustainable Development, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. FAU - Sirbu, Dana Manuela AU - Sirbu DM AUID- ORCID: 0009-0001-0514-5829 AD - Department of Community Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. AD - Research Center in Preventive Medicine, Health Promotion and Sustainable Development, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. FAU - Popa, Monica AU - Popa M AD - Department of Community Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. AD - Research Center in Preventive Medicine, Health Promotion and Sustainable Development, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. FAU - Curseu, Daniela AU - Curseu D AD - Department of Community Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. AD - Research Center in Preventive Medicine, Health Promotion and Sustainable Development, Iuliu Hatieganu University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania. FAU - Borda, Ileana Monica AU - Borda IM AUID- ORCID: 0000-0002-6337-8831 AD - Department of Medical Specialties, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania. FAU - Ungur, Rodica Ana AU - Ungur RA AD - Department of Medical Specialties, Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, 8 Victor Babes Street, 400012 Cluj-Napoca, Romania. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260504 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 SB - IM MH - Humans MH - Romania/epidemiology MH - Female MH - Male MH - *Sleep Quality MH - *Students, Medical/psychology/statistics & numerical data MH - *Life Style MH - Cross-Sectional Studies MH - *COVID-19/epidemiology/psychology MH - Adult MH - Surveys and Questionnaires MH - Young Adult MH - Sleep Initiation and Maintenance Disorders/epidemiology MH - Exercise MH - Quality of Life MH - SARS-CoV-2 PMC - PMC13209030 OTO - NOTNLM OT - alcohol consumption OT - diet OT - illicit drugs OT - lifestyle choices OT - nutritional status OT - physical activity OT - risky behaviors OT - sleep quality OT - students OT - wellbeing COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:33 MHDA- 2026/05/27 06:34 PMCR- 2026/05/04 CRDT- 2026/05/27 01:12 PHST- 2026/03/08 00:00 [received] PHST- 2026/04/16 00:00 [revised] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/05/27 06:34 [medline] PHST- 2026/05/27 06:33 [pubmed] PHST- 2026/05/27 01:12 [entrez] PHST- 2026/05/04 00:00 [pmc-release] AID - medicina62050880 [pii] AID - medicina-62-00880 [pii] AID - 10.3390/medicina62050880 [doi] PST - epublish SO - Medicina (Kaunas). 2026 May 4;62(5):880. doi: 10.3390/medicina62050880. PMID- 42194890 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 10 DP - 2026 May 20 TI - Interferon-gamma and Interleukin-10 Profiles Correlate with Disease Severity in Sudanese Children with Plasmodium falciparum Malaria. LID - 10.3390/jcm15103929 [doi] LID - 3929 AB - Background/Objectives: Severe Plasmodium falciparum malaria remains a leading cause of childhood morbidity and mortality in sub-Saharan Africa. The clinical outcome is largely driven by the balance between pro-inflammatory and anti-inflammatory cytokines. However, immunological data from Sudanese children remain limited and the diagnostic utility of cytokine biomarkers has not been formally evaluated in this population. Therefore, this study aims to compare plasma levels of IFN-gamma and IL-10 among Sudanese children with severe malaria (SM), uncomplicated malaria (UM) and healthy controls (HC) and to evaluate their diagnostic accuracy using in differentiating SM from UM cases. Methods: A hospital-based case-control study was conducted at Mohamed Elamin Hamid Pediatric Hospital, Omdurman, Sudan. The study enrolled 105 children (aged 3 months to 16 years) divided into three age- and sex-matched groups (n = 35 per group): SM, UM and HC. Plasma cytokines IFN-gamma and IL-10 were measured by ELISA. Results: The anthropometric measurements did not differ significantly across the groups. SM was significantly associated with lower hemoglobin and markedly reduced platelet counts. Both IFN-gamma and IL-10 were significantly elevated in SM versus UM and HC (p < 0.001). A strong positive correlation was observed between IFN-gamma and IL-10 (rho = 0.688, p < 0.001) in malaria patients. Additionally, a significant correlation was observed between IL-10 and platelet count (rho = -0.338, p = 0.009). Both IL-10 (AUC = 0.0.720) and IFN-gamma (AUC = 0.687) demonstrated moderate diagnostic performance in discriminating between SM vs. UM. Conclusions: Elevated levels of IFN-gamma and IL-10 strongly associated with severe P. falciparum malaria in Sudanese children. Measuring IL-10 and IFN-gamma at the time of presentation may differentiate between SM and UM cases. Further studies are needed. FAU - Hajali, Tassneem Awad AU - Hajali TA AUID- ORCID: 0009-0000-4159-9572 AD - Department of Clinical Science, College of Medicine, Sulaiman AlRajhi University, AlBukayriah 51941, Qassim, Saudi Arabia. FAU - Mekki, Muna Ismail Elmisbah AU - Mekki MIE AD - Department of Pediatrics, College of Medicine, Sudan University for Science and Technology, Khartoum 11111, Sudan. FAU - Alaagib, Nouralsalhin A AU - Alaagib NA AD - Department of Basic Science, College of Medicine, Sulaiman AlRajhi University, AlBukayriyah 51941, Qassim, Saudi Arabia. FAU - Omer, Islamia Ibrahim Ahmed AU - Omer IIA AUID- ORCID: 0009-0002-0806-1628 AD - Department of Clinical Science, College of Medicine, Sulaiman AlRajhi University, AlBukayriah 51941, Qassim, Saudi Arabia. FAU - Yahia, Rabab Mahadi AU - Yahia RM AD - Department of Pediatrics, Maternity and Children Hospital, Buraidah 52384, Qassim, Saudi Arabia. FAU - Hamdan, Hamdan Z AU - Hamdan HZ AUID- ORCID: 0000-0001-9269-8239 AD - Department of Pathology, College of Medicine, Qassim University, Buraidah 51452, Qassim, Saudi Arabia. LA - eng GR - (QU-APC-2026)/Qassim University/ PT - Journal Article DEP - 20260520 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13207029 OTO - NOTNLM OT - Plasmodium falciparum OT - Sudanese children OT - biomarkers OT - cytokines OT - interferon-gamma OT - interleukin 10 OT - severe malaria COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:36 MHDA- 2026/05/27 06:37 PMCR- 2026/05/20 CRDT- 2026/05/27 01:11 PHST- 2026/04/12 00:00 [received] PHST- 2026/05/14 00:00 [revised] PHST- 2026/05/16 00:00 [accepted] PHST- 2026/05/27 06:37 [medline] PHST- 2026/05/27 06:36 [pubmed] PHST- 2026/05/27 01:11 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - jcm15103929 [pii] AID - jcm-15-03929 [pii] AID - 10.3390/jcm15103929 [doi] PST - epublish SO - J Clin Med. 2026 May 20;15(10):3929. doi: 10.3390/jcm15103929. PMID- 42194659 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 10 DP - 2026 May 11 TI - Relative Trunk Adipopenia Is Associated with the Severity of Liver Disease and Outcome in Patients with Cirrhosis. LID - 10.3390/jcm15103697 [doi] LID - 3697 AB - Background/Objectives: Regional adipose tissue has been studied as a prognostic factor in various extra-hepatic diseases, but data in the setting of cirrhosis is scarce. Our aim was to evaluate the association of regional adipose tissue indices with the severity of liver disease and its impact on the outcome of patients with cirrhosis. Methods: Three hundred and thirty-seven patients with cirrhosis were prospectively enrolled in the study. Clinical and laboratory data were recorded, and MELD-Na and Child-Turcotte-Pugh scores were calculated. Physical performance was evaluated with handgrip strength, the Short Physical Performance Battery test, and the Liver Frailty Index. Dual-energy X-ray absorptiometry was used for the evaluation of total and regional lean and fat mass. Results: A low trunk fat percentage was found to be independently associated with a MELD-Na score >/= 15 (Odds Ratio: 0.92, p = 0.007). MELD-Na score and trunk fat percentage were the only factors independently associated with mortality [Hazard Ratio (HR): 1.078, p = 0.02 and HR: 0.95, p = 0.03, respectively], while a separate analysis based on gender confirmed this finding only in men. In the total cohort, patients with a trunk fat percentage < 27.5% had worse outcomes (log-rank 11.4; p < 0.001). Conclusions: This study marks the first effort to examine the association of indices related to regional adipose tissue distribution with the severity of liver disease and outcome. Trunk fat percentage was the only body composition parameter independently associated with advanced liver disease and prognosis in the total cohort specifically in men, but not in women. Further studies are needed to validate the predictive role of adipose tissue in patients with cirrhosis. FAU - Kamiliou, Aikaterini AU - Kamiliou A AUID- ORCID: 0009-0009-7254-4617 AD - First Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Adamantou, Magdalini AU - Adamantou M AUID- ORCID: 0009-0000-3306-050X AD - First Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Pergantina, Eleni AU - Pergantina E AD - First Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Rachiotis, Nikolaos AU - Rachiotis N AD - First Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Bali, Triada AU - Bali T AD - First Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Mouziouras, Dimitrios AU - Mouziouras D AD - First Department of Gastroenterology, General Hospital of Athens "Laiko", Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Lakiotaki, Dimitra AU - Lakiotaki D AD - First Department of Gastroenterology, General Hospital of Athens "Laiko", Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Lekakis, Vasileios AU - Lekakis V AUID- ORCID: 0000-0002-6105-4147 AD - First Department of Gastroenterology, General Hospital of Athens "Laiko", Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Alexopoulou, Alexandra AU - Alexopoulou A AD - Second Department of Internal Medicine, "Hippokration" General Hospital of Athens, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Papatheodoridis, George V AU - Papatheodoridis GV AUID- ORCID: 0000-0002-3518-4060 AD - First Department of Gastroenterology, General Hospital of Athens "Laiko", Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Cholongitas, Evangelos AU - Cholongitas E AUID- ORCID: 0000-0002-3645-582X AD - First Department of Internal Medicine, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. AD - First Department of Gastroenterology, General Hospital of Athens "Laiko", Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece. LA - eng PT - Journal Article DEP - 20260511 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13207654 OTO - NOTNLM OT - adipopenia OT - adipose tissue OT - body composition OT - end-stage liver disease OT - fat OT - frailty OT - liver transplantation OT - prognosis OT - sarcopenia COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:39 MHDA- 2026/05/27 06:40 PMCR- 2026/05/11 CRDT- 2026/05/27 01:10 PHST- 2026/03/27 00:00 [received] PHST- 2026/05/04 00:00 [revised] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/05/27 06:40 [medline] PHST- 2026/05/27 06:39 [pubmed] PHST- 2026/05/27 01:10 [entrez] PHST- 2026/05/11 00:00 [pmc-release] AID - jcm15103697 [pii] AID - jcm-15-03697 [pii] AID - 10.3390/jcm15103697 [doi] PST - epublish SO - J Clin Med. 2026 May 11;15(10):3697. doi: 10.3390/jcm15103697. PMID- 42194591 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 10 DP - 2026 May 9 TI - Growth Patterns and Factors Associated with Short Stature in Saudi Children and Adolescents with Type 1 Diabetes Mellitus: A Retrospective Cross-Sectional Study. LID - 10.3390/jcm15103629 [doi] LID - 3629 AB - Background: The impact of Type 1 Diabetes Mellitus (T1DM) on linear growth in children remains unclear, with conflicting evidence regarding the roles of glycemic control, disease duration, and nutritional factors. This study aimed to assess growth patterns and identify factors independently associated with short stature among Saudi school-age children and adolescents with T1DM, comparing them to a healthy control group. Methods: A retrospective cross-sectional study was conducted at an endocrinology clinic, including 250 patients with T1DM aged 5-18 years and 267 healthy controls. After propensity score matching, 231 patients were matched to 231 controls. Data were extracted from electronic medical records using a standardized form. Anthropometric measurements were converted to Z-scores and percentiles using validated Saudi growth charts. Short stature was defined as height below the third percentile for age and gender. Univariate and multivariable logistic regression analyses were performed to identify factors associated with short stature among T1DM participants. Results: The median age of the 250 T1DM participants was 13.0 [10.0-15.0] years, with a slight male predominance (58.0%). Of them, 6 (2.4%) children were tall, 30 (12.0% were short), and 214 (85.6%) were normal. A significantly higher proportion of short stature was observed in the T1DM group compared with the control group (6.1% vs. 1.7%; p = 0.016). Among T1DM participants, the proportion of short stature increased progressively with diabetes duration: 3.0% in new-onset disease, 14.9% in intermediate duration (2-5 years), and 25.0% in long-standing disease (>5 years) (p = 0.001). Age at onset of T1DM was also significantly associated with having short stature (p = 0.036). In multivariable analysis, intermediate duration (adjusted odds ratio [aOR] = 5.72, 95% CI (1.02-32.1); p = 0.047) and long-standing duration (aOR = 11.03, 95% CI: (1.09-111.45); p = 0.042) remained significant independent predictors of short stature. In contrast, glycemic control (HbA1c), vitamin D status, time in range, and treatment adherence were not significantly associated with short stature after adjustment. Conclusions: Children and adolescents with T1DM have significantly lower height percentiles and a higher prevalence of short stature compared to their controls. Diabetes duration is a strong, independent predictor of short stature in this population, with progressively higher risk as disease duration lengthens, regardless of glycemic control status. These findings underscore the necessity of systematic longitudinal growth monitoring, particularly in patients with disease duration exceeding five years, to enable early identification and intervention for those at highest risk of growth impairment. FAU - Alqahtani, Youssef A AU - Alqahtani YA AUID- ORCID: 0009-0001-8162-6288 AD - Department of Child Health, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. FAU - A Shati, Ayed AU - A Shati A AUID- ORCID: 0000-0003-0444-5595 AD - Department of Child Health, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. FAU - Alshaikh, Ayoub Ali AU - Alshaikh AA AD - Family and Community Medicine Department, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. FAU - Fardan, Zeinh Hussein AU - Fardan ZH AD - Department of Child Health, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. FAU - Alhuwail, Roaa Saad AU - Alhuwail RS AD - Asser Health Cluster, Ministry of Health, Abha 62523, Saudi Arabia. FAU - Almosleh, Dalia Salem A AU - Almosleh DSA AD - College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. FAU - Alshehri, Abeer Mohammed AU - Alshehri AM AUID- ORCID: 0009-0002-5076-030X AD - College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. FAU - Asiri, Maram Hadi A AU - Asiri MHA AD - College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. FAU - Hammati, Shaden Essa AU - Hammati SE AUID- ORCID: 0009-0002-4921-2189 AD - College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. FAU - Alsharif, Reema Abdullah S AU - Alsharif RAS AUID- ORCID: 0009-0009-6316-8461 AD - College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. FAU - Ghazy, Ramy Mohamed AU - Ghazy RM AUID- ORCID: 0000-0001-7611-706X AD - Family and Community Medicine Department, College of Medicine, King Khalid University, Abha 61421, Saudi Arabia. AD - Health and Medical Research Centre, King Khalid University, Abha 61421, Saudi Arabia. AD - Tropical Health Department, High Institute of Public Health, Alexandria University, Alexandria 21526, Egypt. LA - eng GR - y, grant number RGP2/461/46/King Khalid University/ PT - Journal Article DEP - 20260509 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13206814 OTO - NOTNLM OT - HbA1c OT - Saudi Arabia OT - children and adolescents OT - diabetes duration OT - growth impairment OT - short stature OT - type 1 diabetes mellitus OT - vitamin D COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:34 MHDA- 2026/05/27 06:35 PMCR- 2026/05/09 CRDT- 2026/05/27 01:10 PHST- 2026/04/13 00:00 [received] PHST- 2026/05/05 00:00 [revised] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/05/27 06:35 [medline] PHST- 2026/05/27 06:34 [pubmed] PHST- 2026/05/27 01:10 [entrez] PHST- 2026/05/09 00:00 [pmc-release] AID - jcm15103629 [pii] AID - jcm-15-03629 [pii] AID - 10.3390/jcm15103629 [doi] PST - epublish SO - J Clin Med. 2026 May 9;15(10):3629. doi: 10.3390/jcm15103629. PMID- 42194143 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 5 DP - 2026 Apr 29 TI - Development and Validation of Non-Invasive Machine-Learning Screening Models for Pediatric Malnutrition in Hospitalized Children: A Single-Center Study. LID - 10.3390/children13050617 [doi] LID - 617 AB - Background/Objectives: Child malnutrition is a global health challenge linked to poor growth, impaired development, weakened immunity, and adverse outcomes. Early risk detection is essential, but current screening tools differ in accuracy and feasibility. This study aimed to develop and validate new bedside pediatric malnutrition screening models based on machine learning and evolutionary computation methods that can capture complex patterns in non-invasive clinical indicators while remaining practical for routine ward use. Methods: We conducted a cross-sectional study including 180 hospitalized children (1 month-18 years) recruited consecutively from six pediatric wards. The required sample size (minimum 138 participants) was calculated a priori using national prevalence estimates of pediatric undernutrition (4-9.5%) to ensure adequate precision at a 95% confidence level. Data collection included a questionnaire, anthropometry, subjective malnutrition risk assessment, and the Subjective Global Nutritional Assessment (SGNA) tool. Screening models were developed using decision trees, random forests, XGBoost, lasso regression, artificial neural networks, ANFIS, and genetic programming. Their performance was evaluated against the SGNA tool and physician-based subjective malnutrition risk assessment using sensitivity, specificity, AUC, and Cohen's kappa. Results: Machine learning and intelligent evolutionary models (GP, ANN, and ANFIS) showed the best performance in this sample, with substantial to high agreement (kappa = 0.81-1.00) and high diagnostic accuracy (AUC = 0.92-1.00) with the subjective malnutrition risk assessment. The GP model demonstrated the highest apparent accuracy in this dataset, but also higher complexity, whereas simpler models such as decision trees showed lower accuracy but greater interpretability and feasibility for routine clinical use. However, validation was performed on a relatively small independent sample, and no external validation was conducted, which may limit the generalizability of the findings. Conclusions: While complex models may serve as digital assessment instruments, simpler models are rapid and more suitable for bedside screening. All developed models are non-invasive and cost-effective and show potential for supportive approaches for early detection of malnutrition risk at hospital admission. However, given the limited validation sample and the absence of external validation, these findings should be interpreted with caution, and further large-scale, multicenter studies are required to confirm generalizability and clinical applicability. FAU - Klanjsek, Petra AU - Klanjsek P AD - Faculty of Health Sciences, University of Maribor, Zitna ulica 15, 2000 Maribor, Slovenia. FAU - Brzan, Petra Povalej AU - Brzan PP AUID- ORCID: 0000-0001-7872-586X AD - Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia. AD - Faculty of Electrical Engineering and Computer Science, University of Maribor, Koroska cesta 46, 2000 Maribor, Slovenia. FAU - Varda, Natasa Marcun AU - Varda NM AUID- ORCID: 0000-0003-0634-3576 AD - Faculty of Medicine, University of Maribor, Taborska ulica 8, 2000 Maribor, Slovenia. AD - University Division of Paediatrics, University Medical Centre Maribor, Ljubljanska ulica 5, 2000 Maribor, Slovenia. FAU - Mocnik, Mirjam AU - Mocnik M AD - University Division of Paediatrics, University Medical Centre Maribor, Ljubljanska ulica 5, 2000 Maribor, Slovenia. FAU - Golob Jancic, Sonja AU - Golob Jancic S AUID- ORCID: 0000-0002-6201-7321 AD - University Division of Paediatrics, University Medical Centre Maribor, Ljubljanska ulica 5, 2000 Maribor, Slovenia. FAU - Kovacic, Miha AU - Kovacic M AD - Faculty of Mechanical Engineering, University of Ljubljana, Askerceva cesta 6, 1000 Ljubljana, Slovenia. AD - College of Industrial Engineering, Mariborska cesta 2, 3000 Celje, Slovenia. AD - Store Steel d.o.o., Zelezarska cesta 3, 3220 Store, Slovenia. FAU - Pajnkihar, Majda AU - Pajnkihar M AD - Faculty of Health Sciences, University of Maribor, Zitna ulica 15, 2000 Maribor, Slovenia. LA - eng PT - Journal Article DEP - 20260429 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13204657 OTO - NOTNLM OT - SGNA OT - evolutionary computation OT - genetic programming OT - machine learning OT - malnutrition risk screening OT - nutritional assessment tool OT - nutritional risk screening/assessment OT - nutritional screening tools OT - pediatric malnutrition OT - pediatric undernutrition COIS- Author Miha Kovacic was employed by the company Store Steel d.o.o. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/27 06:33 MHDA- 2026/05/27 06:34 PMCR- 2026/04/29 CRDT- 2026/05/27 01:09 PHST- 2026/03/27 00:00 [received] PHST- 2026/04/24 00:00 [revised] PHST- 2026/04/25 00:00 [accepted] PHST- 2026/05/27 06:34 [medline] PHST- 2026/05/27 06:33 [pubmed] PHST- 2026/05/27 01:09 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - children13050617 [pii] AID - children-13-00617 [pii] AID - 10.3390/children13050617 [doi] PST - epublish SO - Children (Basel). 2026 Apr 29;13(5):617. doi: 10.3390/children13050617. PMID- 42194127 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 5 DP - 2026 Apr 27 TI - Developing a Mindfulness Program for Families in a Pediatric Weight Management Clinic. LID - 10.3390/children13050601 [doi] LID - 601 AB - Background/Objectives: Pediatric obesity is a public health epidemic in the United States and in many countries worldwide. Due to the interrelatedness of obesity and toxic stress, mindfulness is a promising practice to support healthful eating behaviors and combat stress in the management of this condition. In this pilot study we evaluated the acceptability and feasibility of implementing a brief mindfulness-based program for pediatric patients seeking treatment for overweight and obesity, with an assessment of exploratory outcomes. Methods: Nineteen children (ages 8-17 with body mass indices (BMIs) >/= the 85th percentile) and caregiver dyads (n = 19) were recruited from a multidisciplinary pediatric weight management clinic. Four thirty-minute psychoeducational mindfulness-based sessions were provided via telehealth. Qualitative feedback was sought during and after program completion. Child and caregiver mindful eating and general mindfulness measures were collected from participant dyads at baseline, and one month and three months after program completion. Results: Qualitative program feedback from participants was generally positive. Session attendance rates were high (89%), with most participants highly engaged during sessions and the follow-up clinic visits. An analysis of exploratory measures data revealed no significant changes in child or caregiver dyad mindful eating or general mindfulness scores at one month (n = 9) or three months (n = 7) post-program completion compared to baseline (n = 10). Conclusions: This pilot, mindfulness-based program was feasible and acceptable to implement as a scalable behavioral intervention in long-term pediatric obesity treatment. Study of a larger, controlled sample is needed to determine the impact of program participation on mindful eating and general mindfulness, along with clinical obesity-related outcomes, in the management of pediatric obesity. FAU - Lane, Megan AU - Lane M AUID- ORCID: 0009-0001-5339-968X AD - Department of Developmental Behavioral Pediatrics, University of California Los Angeles, Los Angeles, CA 90095, USA. AD - Division of Developmental Pediatrics, University of Tennessee Health Science Center, Memphis, TN 38163, USA. FAU - Verdugo, Bobby AU - Verdugo B AD - Department of Developmental Behavioral Pediatrics, University of California Los Angeles, Los Angeles, CA 90095, USA. FAU - Emerson, Natacha D AU - Emerson ND AUID- ORCID: 0000-0002-4702-9412 AD - Department of Psychiatry & Biobehavioral Sciences, University of California Los Angeles, Los Angeles, CA 90095, USA. FAU - Kim, Miranda AU - Kim M AD - Semel Healthy Campus Initiative Center, University of California Los Angeles, Los Angeles, CA 90095, USA. FAU - Zhang, Qiang AU - Zhang Q AD - David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. FAU - Thang, Christine K AU - Thang CK AUID- ORCID: 0000-0002-5264-2107 AD - Department of Pediatrics, University of California Los Angeles, Los Angeles, CA 90095, USA. FAU - Garell, Cambria L AU - Garell CL AUID- ORCID: 0000-0002-6399-5370 AD - Department of Pediatrics, University of California Los Angeles, Los Angeles, CA 90095, USA. FAU - Depas, Allison Gabriella AU - Depas AG AD - David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA. FAU - Slusser, Wendelin M AU - Slusser WM AUID- ORCID: 0000-0003-3831-2192 AD - Semel Healthy Campus Initiative Center, University of California Los Angeles, Los Angeles, CA 90095, USA. FAU - Boyce, Shanika AU - Boyce S AUID- ORCID: 0000-0002-7568-2785 AD - Department of Pediatrics, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA. FAU - Guerrero, Alma D AU - Guerrero AD AD - Department of Pediatrics, University of California Los Angeles, Los Angeles, CA 90095, USA. LA - eng GR - 21-10317/California Department of Health Care Services University of California-Los Angeles (UCLA)/ University of California-San Francisco (UCSF) ACEs Aware Family Resilience Network/ GR - R01 MD016135-01/National Institute of Child Health and Human Development/ PT - Journal Article DEP - 20260427 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13204384 OTO - NOTNLM OT - mindfulness OT - multidisciplinary clinic OT - pediatric obesity OT - program evaluation COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/05/27 06:36 MHDA- 2026/05/27 06:37 PMCR- 2026/04/27 CRDT- 2026/05/27 01:09 PHST- 2026/03/05 00:00 [received] PHST- 2026/04/01 00:00 [revised] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/05/27 06:37 [medline] PHST- 2026/05/27 06:36 [pubmed] PHST- 2026/05/27 01:09 [entrez] PHST- 2026/04/27 00:00 [pmc-release] AID - children13050601 [pii] AID - children-13-00601 [pii] AID - 10.3390/children13050601 [doi] PST - epublish SO - Children (Basel). 2026 Apr 27;13(5):601. doi: 10.3390/children13050601. PMID- 42194120 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 5 DP - 2026 Apr 24 TI - Impact of Gastric pH on Milk Protein Hydrolysis: A Pilot In Vitro Study Using Pediatric Human Gastric Juice in the Context of Infant Digestive Physiology. LID - 10.3390/children13050595 [doi] LID - 595 AB - BACKGROUND/OBJECTIVES: Gastroesophageal reflux disease (GERD) is prevalent in infants and frequently managed with acid-suppressive medications that elevate gastric pH. This pilot study aimed to evaluate how varying gastric pH levels (2.5, 4.0 and 6.0) influence the hydrolysis of milk proteins in human milk (HM), cow's milk-based infant formula (CMF), and goat milk-based infant formula (GMF). METHODS: Samples were subjected to a 30 min in vitro gastric digestion using pediatric human gastric juice obtained from clinical donors. Protein degradation was analyzed via SDS-PAGE densitometry, comparing digested aliquots to undigested controls. RESULTS: At pH 2.5, caseins were highly digested in all samples, especially in HM and GMF. At pH 4.0, GMF displayed an apparent 51% greater casein degradation relative to CMF and HM in this pilot analysis. alpha-lactalbumin degradation was markedly higher in GMF at all pH levels; notably, at pH 4.0 and 6.0, only GMF exhibited digestion of this protein. Albumin showed almost complete degradation in HM and GMF at pH 2.5, and GMF maintained greater degradation at higher pH levels. beta-lactoglobulin (absent in HM) was better digested in GMF at pH 2.5, whereas CMF showed higher hydrolysis observed at pH 4.0 and 6.0. Lactoferrin digestion was most efficient in HM and GMF at pH 2.5, with no differences observed at higher pH levels. CONCLUSIONS: These preliminary findings suggest that GMF may offer digestive advantages for infants with GERD under pharmacological acid suppression, particularly regarding casein and alpha-lactalbumin breakdown at higher pH. The distinct digestion kinetics of CMF and GMF at different pH levels provide a physiological basis for targeted infant feeding strategies. Further large-scale studies are required to validate these exploratory observations. FAU - Del Nogal Avila, Maria AU - Del Nogal Avila M AUID- ORCID: 0000-0003-3544-1423 AD - Instituto de Medicina Molecular Aplicada (IMMA) Nemesio Diez, Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Urbanizacion Monteprincipe, 28660 Boadilla del Monte, Spain. FAU - Soria Lopez, Marta AU - Soria Lopez M AD - Pediatrics Department, HM Hospitales, 28938 Madrid, Spain. FAU - Sanchez-Vera, Isabel AU - Sanchez-Vera I AD - Instituto de Medicina Molecular Aplicada (IMMA) Nemesio Diez, Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Urbanizacion Monteprincipe, 28660 Boadilla del Monte, Spain. FAU - Plaza-Clavero, Rosa AU - Plaza-Clavero R AD - Instituto de Medicina Molecular Aplicada (IMMA) Nemesio Diez, Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Urbanizacion Monteprincipe, 28660 Boadilla del Monte, Spain. FAU - Cabello-Rivera, Daniel AU - Cabello-Rivera D AUID- ORCID: 0000-0001-7628-0000 AD - Instituto de Medicina Molecular Aplicada (IMMA) Nemesio Diez, Facultad de Medicina, Universidad San Pablo-CEU, CEU Universities, Urbanizacion Monteprincipe, 28660 Boadilla del Monte, Spain. FAU - Knipping, Karen AU - Knipping K AUID- ORCID: 0000-0002-3700-9047 AD - Ausnutria B.V., 8025 Zwolle, The Netherlands. FAU - Lopez-Escobar, Alejandro AU - Lopez-Escobar A AUID- ORCID: 0000-0002-9052-1429 AD - Facultad de Ciencias de la Salud, Universidad Internacional de la Rioja (UNIR), 28224 Pozuelo de Alarcon, Spain. LA - eng PT - Journal Article DEP - 20260424 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13204711 OTO - NOTNLM OT - gastric pH OT - gastroesophageal reflux (GERD) OT - goat milk formula OT - human gastric juice OT - infant digestion OT - milk protein hydrolysis OT - pediatric nutrition OT - alpha-lactalbumin COIS- Author A.L.-E. has received research grants and participated in clinical trials funded by Ausnutria and has served as a consultant or collaborator for Laboratorios Ordesa and other infant formula manufacturers. Author M.D.N.A. has conducted experimental research supported by funding from Ausnutria. Author M.S.L. has participated in clinical trials funded by Ausnutria and has served as a consultant or collaborator for infant formula manufacturers. Author K.K. is a current employee of Ausnutria. The remaining authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/05/27 06:41 MHDA- 2026/05/27 06:42 PMCR- 2026/04/24 CRDT- 2026/05/27 01:09 PHST- 2026/03/24 00:00 [received] PHST- 2026/04/13 00:00 [revised] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/05/27 06:42 [medline] PHST- 2026/05/27 06:41 [pubmed] PHST- 2026/05/27 01:09 [entrez] PHST- 2026/04/24 00:00 [pmc-release] AID - children13050595 [pii] AID - children-13-00595 [pii] AID - 10.3390/children13050595 [doi] PST - epublish SO - Children (Basel). 2026 Apr 24;13(5):595. doi: 10.3390/children13050595. PMID- 42194009 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2218-273X (Electronic) IS - 2218-273X (Linking) VI - 16 IP - 5 DP - 2026 Apr 28 TI - Inverse Correlation Between Nesfatin-1 and Ghrelin O-Acyltransferase (GOAT) in Adolescents with Epilepsy: A Cross-Sectional Study. LID - 10.3390/biom16050658 [doi] LID - 658 AB - Nesfatin-1 and ghrelin O-acyltransferase (GOAT) have established roles in metabolic regulation and neuronal excitability, yet their relationship in epilepsy remains conflicted. This cross-sectional study compared 22 adolescent epilepsy patients (13.1 +/- 2.0 years; 11 women/11 men) with 20 age-matched healthy controls (HCs) (12.3 +/- 2.2 years; 8 women/12 men). Serum and salivary nesfatin-1 and GOAT levels were measured by enzyme-linked immunosorbent assay; Spearman's rank correlation assessed inter-neuropeptide relationships. Serum nesfatin-1 was markedly elevated in patients with epilepsy compared to HCs (44.04 (interquartile range 38.19-76.72) vs. 8.65 (interquartile range 7.82-9.01) ng/mL, p < 0.001; ~5-fold). Serum GOAT was similarly elevated (4.90 (interquartile range 4.17-6.66) vs. 1.41 (interquartile range 1.21-1.79) ng/mL, p < 0.001; 3.5-fold). A significant inverse correlation between serum nesfatin-1 and GOAT levels was identified in patients with epilepsy (rho = -0.68, 95% CI [-0.86, -0.36], p < 0.001) but not in HCs (p = 0.53) and remained independent of age, sex, body mass index and epilepsy type. This inverse correlation was significant in women (rho = -0.68, p = 0.021) with a similar trend in men (rho = -0.53, p = 0.096). Salivary nesfatin-1 mirrored serum patterns (2.3-fold increase; p < 0.001), while salivary GOAT showed a 9-fold reduction (p < 0.001). This study provides the first evidence of an inverse nesfatin-1/GOAT correlation in adolescent epilepsy, suggesting disease-specific neuroendocrine dysregulation. These exploratory findings support the potential of these neuropeptides as candidate biomarkers warranting further validation and offer new insights into the metabolic-excitability axis in epilepsy. FAU - Sojka, Anna AU - Sojka A AD - Department of Prosthodontics and Gerostomatology, Poznan University of Medical Sciences, 60-812 Poznan, Poland. FAU - Yetkin, Ozgun AU - Yetkin O AUID- ORCID: 0000-0003-4110-8002 AD - Department of Developmental Neurology, Poznan University of Medical Sciences, 60-355 Poznan, Poland. AD - Doctoral School, Poznan University of Medical Sciences, 60-812 Poznan, Poland. FAU - Bartosik, Yasmin AU - Bartosik Y AD - Department of Prosthodontics and Gerostomatology, Poznan University of Medical Sciences, 60-812 Poznan, Poland. FAU - Steinborn, Barbara AU - Steinborn B AD - Department of Developmental Neurology, Poznan University of Medical Sciences, 60-355 Poznan, Poland. FAU - Dorocka-Bobkowska, Barbara AU - Dorocka-Bobkowska B AUID- ORCID: 0000-0003-3659-7761 AD - Department of Prosthodontics and Gerostomatology, Poznan University of Medical Sciences, 60-812 Poznan, Poland. FAU - Zarowski, Marcin AU - Zarowski M AUID- ORCID: 0000-0002-9800-9446 AD - Department of Developmental Neurology, Poznan University of Medical Sciences, 60-355 Poznan, Poland. LA - eng PT - Journal Article DEP - 20260428 PL - Switzerland TA - Biomolecules JT - Biomolecules JID - 101596414 RN - 0 (Nucleobindins) RN - 0 (NUCB2 protein, human) RN - EC 2.3.- (Acyltransferases) RN - EC 2.3.- (MBOAT4 protein, human) RN - 0 (Nerve Tissue Proteins) RN - 0 (DNA-Binding Proteins) RN - 0 (Calcium-Binding Proteins) SB - IM MH - Humans MH - Female MH - *Nucleobindins/blood/metabolism MH - Male MH - Adolescent MH - Cross-Sectional Studies MH - *Epilepsy/blood/metabolism MH - Child MH - *Acyltransferases/blood/metabolism MH - *Nerve Tissue Proteins/blood MH - Case-Control Studies MH - *DNA-Binding Proteins/blood MH - Saliva/metabolism MH - Calcium-Binding Proteins/blood PMC - PMC13204653 OTO - NOTNLM OT - adolescents OT - biomarkers OT - epilepsy OT - ghrelin OT - ghrelin o-acyltransferase OT - nesfatin-1 OT - neuropeptides COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:34 MHDA- 2026/05/27 06:35 PMCR- 2026/04/28 CRDT- 2026/05/27 01:08 PHST- 2026/03/05 00:00 [received] PHST- 2026/04/18 00:00 [revised] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/05/27 06:35 [medline] PHST- 2026/05/27 06:34 [pubmed] PHST- 2026/05/27 01:08 [entrez] PHST- 2026/04/28 00:00 [pmc-release] AID - biom16050658 [pii] AID - biomolecules-16-00658 [pii] AID - 10.3390/biom16050658 [doi] PST - epublish SO - Biomolecules. 2026 Apr 28;16(5):658. doi: 10.3390/biom16050658. PMID- 42193668 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 5 DP - 2026 May 15 TI - Determinants of Physical Activity Engagement Among Male Adolescents in Riyadh, Saudi Arabia: A Comparative Study of Athletes and Non-Athletes. LID - 10.3390/bs16050789 [doi] LID - 789 AB - Background: Physical inactivity among Saudi Arabian adolescents is a critical public health concern due to its contribution to the rising prevalence of overweight, obesity, and non-communicable diseases. Despite this, the motivational profiles and perceived barriers that differentiate athletic from non-athletic adolescents remain understudied in the Saudi literature, particularly within the school Physical Education (PE) context. Grounded in Self-Determination Theory (SDT), the present study examined the factors preventing and motivating Saudi adolescents to engage in physical activity (PA) and discusses findings in terms of their implications for PE teachers and school-based intervention. Method: A cross-sectional study was conducted with 124 male high school students in Riyadh (mean age: 16.79 +/- 0.66 years). Participants were categorized as either athletes (n = 70) or non-athletes (n = 54) based on pre-defined engagement criteria: athletes were required to report vigorous-intensity sport participation on three or more days per week for a minimum of 60 min per session. Anthropometric measurements, lifestyle behaviors (diet, screen time, sleep), motivations, and barriers were assessed using the validated Arab Teens Lifestyle Study (ATLS) questionnaire. Independent samples t-tests and chi-square tests were used to compare between-group differences; effect sizes are reported. Result: Non-athletes had a significantly higher mean BMI (29.40 +/- 6.77 kg/m(2)) and waist circumference (98.65 +/- 21.63 cm) compared to athletes (BMI: 22.19 +/- 4.44 kg/m(2); waist: 78.84 +/- 9.51 cm; both p < 0.001). No significant differences were observed in screen time, sleep duration, or dietary habits. The primary motivations for PA among athletes were health benefits (27.1%), recreation (25.7%), and competition (20.0%), reflecting an autonomous motivational profile consistent with SDT. Among non-athletes, the predominant barriers were the lack of suitable facilities (25.9%) and the absence of an exercise partner (22.2%); reflecting unmet SDT needs for competence and relatedness respectively, while only 9.3% cited having a lack of time. Conclusions: Non-athletic participants face a significant health disadvantage characterized by higher rates of overweight and central obesity. In contrast to global trends, where academic commitments dominate barriers to PA, the principal barriers in this population are environmental and social, reflecting unmet psychological needs that PE teachers are uniquely positioned to address. Rather than focusing solely on infrastructure, PE promoters should implement need-supportive teaching practices, including competence-building tasks and cooperative peer structures, to foster the intrinsic motivational profile observed in the athletes and promote long-term PA adherence among non-athletic students, in alignment with the health objectives of Saudi Vision 2030. FAU - Alaqil, Abdulrahman I AU - Alaqil AI AUID- ORCID: 0000-0003-0458-2354 AD - Department of Physical Education, College of Education, King Faisal University, Al-Ahsa 31982, Saudi Arabia. FAU - Bin Radhyan, Fahad AU - Bin Radhyan F AUID- ORCID: 0000-0003-3037-0435 AD - Department of Physical Education, College of General Studies, King Fahd University of Petroleum and Minerals, Dhahran 31261, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260515 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13203752 OTO - NOTNLM OT - Saudi Arabia OT - Self-Determination Theory OT - adolescents OT - barriers OT - motivation OT - obesity OT - physical activity COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:37 MHDA- 2026/05/27 06:38 PMCR- 2026/05/15 CRDT- 2026/05/27 01:07 PHST- 2026/03/31 00:00 [received] PHST- 2026/05/06 00:00 [revised] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/05/27 06:38 [medline] PHST- 2026/05/27 06:37 [pubmed] PHST- 2026/05/27 01:07 [entrez] PHST- 2026/05/15 00:00 [pmc-release] AID - bs16050789 [pii] AID - behavsci-16-00789 [pii] AID - 10.3390/bs16050789 [doi] PST - epublish SO - Behav Sci (Basel). 2026 May 15;16(5):789. doi: 10.3390/bs16050789. PMID- 42193600 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 5 DP - 2026 May 7 TI - Adolescent Sports Learning Interest and Subjective Well-Being: The Chain Mediating Role of Social Anxiety and Sleep Quality. LID - 10.3390/bs16050721 [doi] LID - 721 AB - OBJECTIVE: While the benefits of physical activity are well-documented, the internal mechanisms linking sports interest to adolescent Subjective Well-being (SWB) remain under-explored. This study addresses this gap by investigating the association between Sports Learning Interest and SWB and examining the serial mediating roles of Social Anxiety and Sleep Quality. METHODS: Using a stratified random sampling method, 1764 primary and secondary students were surveyed with validated instruments, including the PSQI and the Index of Well-Being. Data were analyzed using Hayes' PROCESS macro (Model 6) to test the hypothesized chain mediation effects. RESULTS: Sports Learning Interest significantly and positively predicted SWB. The model identified three significant indirect pathways: independent mediation by Social Anxiety, independent mediation by Sleep Quality, and a serial chain from Social Anxiety --> Sleep Quality (total indirect effect = 0.18, 95% CI [0.15, 0.21]). Notably, Sleep Quality emerged as the core mediator, accounting for 29.9% of the total effect. CONCLUSIONS: Enhancing sports interest is positively associated with SWB through a "psychological-physiological" dual channel-specifically by its association with lower social anxiety and subsequently better sleep. These findings provide empirical evidence for designing school-based interventions that integrate physical education with mental health promotion. FAU - Qi, Hanlin AU - Qi H AD - Faculty of Psychology, Shinawatra University, Bang Toey, Sam Khok, Pathum Thani 12160, Thailand. FAU - Bhutasang, Natchana AU - Bhutasang N AD - Faculty of Psychology, Shinawatra University, Bang Toey, Sam Khok, Pathum Thani 12160, Thailand. FAU - Liu, Shixiang AU - Liu S AD - Department of Psychology, Teachers College of Beijing Union University, Beijing 100011, China. FAU - Zhang, Wen AU - Zhang W AD - School of Psychology, Qufu Normal University, No. 57 Jingxuan West Road, Qufu 273165, China. LA - eng GR - JK202506/Education Science Research Project of Beijing Union University/ PT - Journal Article DEP - 20260507 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC13203127 OTO - NOTNLM OT - adolescent OT - chain mediation OT - sleep quality OT - social anxiety OT - sports learning interest OT - subjective well-being COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:34 MHDA- 2026/05/27 06:35 PMCR- 2026/05/07 CRDT- 2026/05/27 01:07 PHST- 2026/03/12 00:00 [received] PHST- 2026/04/21 00:00 [revised] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/05/27 06:35 [medline] PHST- 2026/05/27 06:34 [pubmed] PHST- 2026/05/27 01:07 [entrez] PHST- 2026/05/07 00:00 [pmc-release] AID - bs16050721 [pii] AID - behavsci-16-00721 [pii] AID - 10.3390/bs16050721 [doi] PST - epublish SO - Behav Sci (Basel). 2026 May 7;16(5):721. doi: 10.3390/bs16050721. PMID- 42193371 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260527 LR - 20260813 IS - 2227-9059 (Print) IS - 2227-9059 (Electronic) IS - 2227-9059 (Linking) VI - 14 IP - 5 DP - 2026 May 4 TI - Environmental Radon Exposure and Inflammatory Responses in Children and Adolescents: Evidence from a High-Radon Region in Kazakhstan. LID - 10.3390/biomedicines14051045 [doi] LID - 1045 AB - Background/Objectives: Radon is a naturally occurring radioactive gas and the leading source of natural radiation exposure worldwide; however, its systemic biological effects in children remain poorly understood. This study examined the association between cumulative indoor radon exposure and inflammatory biomarkers among children residing in rural communities of the Aqmola region in Kazakhstan. Methods: The study included 87 children and adolescents (42 exposed and 45 controls). Radon exposure was measured in residential and school environments, and a composite Radon Exposure Index (REI) was constructed to estimate cumulative exposure over time. Serum concentrations of inflammatory biomarkers, including C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and interleukin-8 (IL-8), were measured using validated immunoassay methods. Multivariable linear regression models adjusted for age, sex, body mass index, pubertal development stage, and heating type were used to evaluate associations between REI and biomarker levels. Results: Children and adolescents living in the radon-exposed community had significantly higher REI values than controls (7.75 +/- 0.85 vs.4.83 +/- 0.41, respectively). Among the biomarkers examined, CRP, TNF-alpha, IL-1beta, IL-8 and IL-6 were not significantly associated with radon exposure. Conclusions: These findings do not support the use of the evaluated inflammatory biomarkers as indicators of early biological effects of environmental radon exposure in this population. However, the clear exposure contrast observed between study settings underscores the ongoing public health relevance of radon as an environmental hazard. Continued efforts to monitor and mitigate radon exposure in high-risk regions remain essential, particularly in environments where children spend substantial amounts of time. FAU - Lesbek, Anel AU - Lesbek A AUID- ORCID: 0009-0005-1231-2946 AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Omori, Yasutaka AU - Omori Y AUID- ORCID: 0000-0003-3629-8761 AD - Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki 036-8564, Japan. FAU - Bakhtin, Meirat AU - Bakhtin M AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Miura, Tomisato AU - Miura T AUID- ORCID: 0000-0003-3104-2134 AD - Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki 036-8564, Japan. FAU - Tokonami, Shinji AU - Tokonami S AUID- ORCID: 0000-0002-6617-7402 AD - Institute of Radiation Emergency Medicine, Hirosaki University, 66-1 Hon-cho, Hirosaki 036-8564, Japan. FAU - Kazymbet, Polat AU - Kazymbet P AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Ibrayeva, Danara AU - Ibrayeva D AUID- ORCID: 0000-0002-1640-1728 AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Altaeva, Nursulu AU - Altaeva N AD - Department of Medical Genetics and Molecular Biology NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Kazhiyakhmetova, Baglan AU - Kazhiyakhmetova B AUID- ORCID: 0009-0009-0357-5989 AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Saifulina, Elena AU - Saifulina E AUID- ORCID: 0000-0002-1791-0137 AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Shokabayeva, Aigerim AU - Shokabayeva A AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Mussayeva, Elvira AU - Mussayeva E AUID- ORCID: 0000-0001-8012-2590 AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Mulkat, Yelshenbek AU - Mulkat Y AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. FAU - Kashkinbayev, Yerlan AU - Kashkinbayev Y AUID- ORCID: 0000-0002-6095-459X AD - Institute of Radiobiology and Radiation Protection NJSC, Astana Medical University, Astana 010000, Kazakhstan. LA - eng GR - grant number IRN AP22786933/Committee of Science of the Ministry of Science and Higher Education of the Republic of Kazakhstan/ PT - Journal Article DEP - 20260504 PL - Switzerland TA - Biomedicines JT - Biomedicines JID - 101691304 PMC - PMC13203900 OTO - NOTNLM OT - Kazakhstan OT - Radon Exposure Index OT - adolescents OT - environmental health OT - environmental radiation OT - inflammatory biomarkers OT - interleukin-8 OT - radon exposure OT - rural populations OT - serum biomarkers COIS- The authors declare no conflicts of interest. EDAT- 2026/05/27 06:39 MHDA- 2026/05/27 06:40 PMCR- 2026/05/04 CRDT- 2026/05/27 01:06 PHST- 2026/04/11 00:00 [received] PHST- 2026/04/29 00:00 [revised] PHST- 2026/05/01 00:00 [accepted] PHST- 2026/05/27 06:40 [medline] PHST- 2026/05/27 06:39 [pubmed] PHST- 2026/05/27 01:06 [entrez] PHST- 2026/05/04 00:00 [pmc-release] AID - biomedicines14051045 [pii] AID - biomedicines-14-01045 [pii] AID - 10.3390/biomedicines14051045 [doi] PST - epublish SO - Biomedicines. 2026 May 4;14(5):1045. doi: 10.3390/biomedicines14051045. PMID- 42192480 OWN - NLM STAT- MEDLINE DCOM- 20260721 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 May 26 TI - Digital addiction comorbidity patterns and their differential links to internalizing symptoms, suicidal behaviors and non-suicidal self-injury in vocational high school students. LID - 10.1186/s40359-026-04873-z [doi] LID - 1077 AB - BACKGROUND: Digital addiction is a growing public health concern among adolescents, yet evidence on co-occurring addiction patterns and their differential associations with mental health outcomes remains limited, particularly in vocational students. METHODS: A cross-sectional survey of 15,311 vocational high school students was conducted in Zigong, China. Smartphone, gaming, and social media addiction were assessed using validated scales. Participants were classified into no addiction, single addiction, and multiple addictions groups. Outcomes included internalizing symptoms (clinically significant depression or anxiety), suicidal behaviors (ideation, planning, or attempts), and non-suicidal self-injury (NSSI). Hierarchical regression models with progressive adjustment were supplemented by sensitivity analyses using continuous scores and operating characteristic (ROC)-derived alternative cut-offs. RESULTS: A total of 20.9% of participants met the criteria for one form of digital addiction, with smartphone-only addiction being the most prevalent pattern (19.4%). A graded association was observed, with the prevalence of all adverse outcomes increasing progressively with the number of addictions (all p < 0.001). In fully adjusted models, single addiction was associated with internalizing symptoms (OR = 1.77, 95% CI: 1.54-2.04), suicidal behaviors (OR = 1.38, 95% CI: 1.24-1.52), and NSSI (OR = 1.42, 95% CI: 1.24-1.63). Multiple addictions were associated with internalizing symptoms (OR = 5.58, 95% CI: 3.71-8.41) and suicidal behaviors (OR = 2.56, 95% CI: 1.74-3.77), but the association with NSSI was attenuated (OR = 1.17, 95% CI: 0.81-1.70, p = 0.404). When the three continuous addiction scores were mutually adjusted, smartphone addiction severity remained independently associated only with internalizing symptoms (OR = 1.05, 95% CI: 1.04-1.06), whereas gaming and social media addiction severities were independently associated with both suicidal behaviors and NSSI. Triple addiction was associated with the highest risk of suicidal behaviors (OR = 3.42, 95% CI: 1.62-7.21). Sensitivity analyses using data-driven ROC-optimal cut-offs preserved the core graded pattern. CONCLUSION: Co-occurring digital addictions are common among vocational students and exhibit graded associations with adverse mental health outcomes. Smartphone addiction appears primarily linked to internalizing distress, while gaming and social media addictions are independently associated with self-harm, underscoring the importance of assessing specific digital activities rather than total screen time. CI - (c) 2026. The Author(s). FAU - Wen, Liping AU - Wen L AD - Department of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, 666 Gongshu Road, Zigong, Sichuan Province, 643020, China. FAU - Xu, Lu AU - Xu L AD - Department of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, 666 Gongshu Road, Zigong, Sichuan Province, 643020, China. FAU - Bai, Li AU - Bai L AD - Department of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, 666 Gongshu Road, Zigong, Sichuan Province, 643020, China. FAU - Zhu, Lingyan AU - Zhu L AD - Department of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, 666 Gongshu Road, Zigong, Sichuan Province, 643020, China. FAU - Liao, Liangxue AU - Liao L AD - Department of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, 666 Gongshu Road, Zigong, Sichuan Province, 643020, China. FAU - He, Ruini AU - He R AD - Department of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, 666 Gongshu Road, Zigong, Sichuan Province, 643020, China. FAU - Liu, Kezhi AU - Liu K AD - Department of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, 666 Gongshu Road, Zigong, Sichuan Province, 643020, China. liukezhi@swmu.edu.cn. AD - Department of Psychiatry, Affliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China. liukezhi@swmu.edu.cn. FAU - Wang, Yilin AU - Wang Y AD - Department of Psychiatry, Zigong Mental Health Center, the Zigong Affiliated Hospital, Southwest Medical University, 666 Gongshu Road, Zigong, Sichuan Province, 643020, China. wangyilinzg0321@163.com. LA - eng GR - 2025-NKY-01-01/the Zigong Key Science and Technology Plan (Collaborative Innovation Project of Zigong Institute of Brain Sciences)/ PT - Journal Article DEP - 20260526 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Adolescent MH - *Students/psychology/statistics & numerical data MH - China/epidemiology MH - Comorbidity MH - Female MH - *Self-Injurious Behavior/epidemiology/psychology MH - *Internet Addiction Disorder/epidemiology/psychology MH - Cross-Sectional Studies MH - *Behavior, Addictive/epidemiology/psychology MH - Male MH - Smartphone MH - Digital Media MH - Suicidal Ideation MH - *Social Media MH - *Depression/epidemiology MH - *Anxiety/epidemiology PMC - PMC13386748 OTO - NOTNLM OT - Digital addiction OT - Gaming disorder OT - Sleep disturbance OT - Smartphone addiction OT - Social media addiction OT - Suicidal behaviors OT - Vocational high school students COIS- Declarations. Ethics approval and consent to participate: This investigation strictly followed the Declaration of Helsinki, and received ethical approval from received ethical approval from the Zigong Mental Health Center in China (Approval No. 2020-8-01). Written informed consent was obtained from all participants aged 18 or above, while in the case of minors, parental or legal guardian consent was obtained, alongside student assent. All data were anonymized and stored securely. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/27 06:34 MHDA- 2026/07/21 06:34 PMCR- 2026/05/26 CRDT- 2026/05/27 00:35 PHST- 2026/03/12 00:00 [received] PHST- 2026/05/22 00:00 [accepted] PHST- 2026/07/21 06:34 [medline] PHST- 2026/05/27 06:34 [pubmed] PHST- 2026/05/27 00:35 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - 10.1186/s40359-026-04873-z [pii] AID - 4873 [pii] AID - 10.1186/s40359-026-04873-z [doi] PST - epublish SO - BMC Psychol. 2026 May 26;14(1):1077. doi: 10.1186/s40359-026-04873-z. PMID- 42191258 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260728 IS - 1873-4324 (Electronic) IS - 0003-2670 (Linking) VI - 1410 DP - 2026 Aug 8 TI - CARES-Net: a channel-attention residual network for multi-disease classification in small-sample (1)H NMR metabolomics data. PG - 345614 LID - S0003-2670(26)00564-7 [pii] LID - 10.1016/j.aca.2026.345614 [doi] AB - BACKGROUND: NMR-based metabolomics is widely used in disease diagnosis due to its non-destructive and quantitative advantages. However, its analytical performance is often limited by the high-dimensional feature space derived from segmented 1D (1)H NMR spectra, excessive feature variables, and small sample sizes. These characteristics impede accurate correlation analysis, reduce model robustness, and frequently cause overfitting and unstable classification results. Existing statistical and machine learning methods struggle to effectively capture nonlinear metabolic patterns under such conditions. Therefore, there is a clear need for a more robust and intelligent analytical framework to improve disease classification accuracy in small-sample NMR-based metabolomics. RESULTS: We propose CARES-Net, a channel-attention residual network specifically designed for (1)H NMR-based small-sample metabolomics disease classification. The model integrates residual connections with a channel attention mechanism to adaptively reweight spectral features, thereby enhancing informative metabolite signals while suppressing noise and redundant variables. Serum (1)H NMR datasets from children with malnutrition and patients with pancreatic ductal adenocarcinoma (PDAC) were used to evaluate the model. To address sample imbalance and feature redundancy, the SMOTE algorithm was applied for data augmentation and XGBoost was employed for feature selection. CARES-Net achieved classification accuracies of 86.25% for malnutrition and 92.50% for PDAC, significantly outperforming traditional machine learning models and representative deep learning approaches, demonstrating superior feature learning and generalization capabilities under small-sample conditions. SIGNIFICANCE: This study demonstrate that CARES-Net provides an effective solution to the challenges of high dimensionality and limited sample sizes in NMR-based metabolomics. By improving feature representation and classification stability, the proposed method enhances diagnostic reliability and accuracy. This work offers a promising analytical framework for small-sample metabolomics studies and supports the development of intelligent diagnostic systems. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Ye, Zihang AU - Ye Z AD - Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, 361005, China. FAU - Guo, Yucheng AU - Guo Y AD - Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, 361005, China. FAU - Ji, Zhicheng AU - Ji Z AD - Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, 361005, China. FAU - Zhu, Hongwei AU - Zhu H AD - Department of Pediatric, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, China. FAU - Feng, Jianghua AU - Feng J AD - Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, 361005, China. FAU - Shen, Guiping AU - Shen G AD - Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen, 361005, China. Electronic address: gpshen@xmu.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260505 PL - Netherlands TA - Anal Chim Acta JT - Analytica chimica acta JID - 0370534 SB - IM MH - *Metabolomics/methods MH - Humans MH - *Proton Magnetic Resonance Spectroscopy OTO - NOTNLM OT - Channel attention OT - Deep learning OT - Metabolomics OT - Multi-disease classification OT - Nuclear magnetic resonance COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/27 00:30 MHDA- 2026/05/27 00:31 CRDT- 2026/05/26 20:59 PHST- 2025/12/23 00:00 [received] PHST- 2026/04/22 00:00 [revised] PHST- 2026/05/03 00:00 [accepted] PHST- 2026/05/27 00:31 [medline] PHST- 2026/05/27 00:30 [pubmed] PHST- 2026/05/26 20:59 [entrez] AID - S0003-2670(26)00564-7 [pii] AID - 10.1016/j.aca.2026.345614 [doi] PST - ppublish SO - Anal Chim Acta. 2026 Aug 8;1410:345614. doi: 10.1016/j.aca.2026.345614. Epub 2026 May 5. PMID- 42191217 OWN - NLM STAT- MEDLINE DCOM- 20260526 LR - 20260813 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 10 IP - 1 DP - 2026 May 26 TI - Temporal trends, geographic patterns and predictors of chronic health conditions in Australian children: a mixed multilevel analysis. LID - 10.1136/bmjpo-2025-003969 [doi] LID - e003969 AB - OBJECTIVE: This study examined temporal trends, spatial distribution and multilevel predictors of chronic conditions using nationally representative data from the Longitudinal Study of Australian Children. STUDY DESIGN: Longitudinal population-based cohort study using multilevel and spatial analyses. METHODS: Multilevel mixed-effects logistic regression models were used to identify child-level, parent-level and context-level predictors across waves 2-8. Model fit was assessed using the intraclass correlation coefficient and Akaike Information Criterion. Spatial mapping was performed using Statistical Area Level 2. Significance was set at p < 0.05. RESULTS: The prevalence of chronic conditions rose from 32.1% to 58.7%. Significant child-level predictors included severe sleep problems (adjusted odd ratio (AOR) = 2.98), sedentary behaviour (AOR = 1.27), poor diet (low fruit/vegetable intake: AOR = 1.14; high-fat foods: AOR = 1.88), sugary drink intake (AOR = 1.23) and obesity (AOR = 1.43). Parental and contextual predictors included Indigenous status (AOR = 1.68), financial hardship (AOR = 1.16), maternal medical conditions (AOR = 1.48), paternal depression (AOR = 1.61), low household income ($A <500: AOR = 1.26), paternal smoking (AOR = 1.41), heavy alcohol consumption by mothers (AOR = 1.77) and fathers (AOR = 1.72), residence in non-metropolitan areas (AOR = 1.53) and living in moderately to very remote areas (AOR = 2.01). CONCLUSION: Chronic conditions among Australian children are increasing, driven by interconnecting child, family and geographic risk factors. Multilevel interventions are needed to address these rising inequalities. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Abebe, Ayele Mamo AU - Abebe AM AUID- ORCID: 0000-0002-1801-8167 AD - Pediatric & Child Health Nursing Department, Debre Berhan University, Debre Berhan, Amhara, Ethiopia ayelemamo12@gmail.com. AD - University of Southern Queensland, Toowoomba, Queensland, Australia. FAU - Hoque, Zahirul AU - Hoque Z AD - University of Southern Queensland, Toowoomba, Queensland, Australia. FAU - Khanam, Rasheda AU - Khanam R AD - University of Southern Queensland, Toowoomba, Queensland, Australia. LA - eng PT - Journal Article DEP - 20260526 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - Australia/epidemiology MH - *Chronic Disease/epidemiology MH - Logistic Models MH - Longitudinal Studies MH - Multilevel Analysis MH - Prevalence MH - Risk Factors MH - Sedentary Behavior MH - Socioeconomic Factors MH - *Health Status PMC - PMC13218166 OTO - NOTNLM OT - Adolescent Health OT - Child Health OT - Health services research COIS- Competing interests: No, there are no competing interests. EDAT- 2026/05/27 00:30 MHDA- 2026/05/27 00:31 PMCR- 2026/05/26 CRDT- 2026/05/26 20:43 PHST- 2025/08/11 00:00 [received] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/05/27 00:31 [medline] PHST- 2026/05/27 00:30 [pubmed] PHST- 2026/05/26 20:43 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - 10.1136/bmjpo-2025-003969 [pii] AID - bmjpo-2025-003969 [pii] AID - 10.1136/bmjpo-2025-003969 [doi] PST - epublish SO - BMJ Paediatr Open. 2026 May 26;10(1):e003969. doi: 10.1136/bmjpo-2025-003969. PMID- 42190641 OWN - NLM STAT- MEDLINE DCOM- 20260526 LR - 20260813 IS - 2561-1011 (Electronic) IS - 2561-1011 (Linking) VI - 10 DP - 2026 May 26 TI - Sleep and Cardiovascular Health Among Women With a History of Hypertensive Disorders of Pregnancy: Pilot Observational Study. PG - e81118 LID - 10.2196/81118 [doi] LID - e81118 AB - BACKGROUND: Both poor sleep health and hypertensive disorders of pregnancy (HDP) are independent risk factors for cardiovascular disease. Whether poor postpartum sleep contributes to the relationship between HDP and future cardiovascular disease is unknown. This pilot study evaluated the feasibility and acceptability of studying sleep health using a wearable device (Oura ring) among mothers of young children. OBJECTIVE: We evaluated indices of sleep health both objectively with the Oura ring and subjectively via questionnaires and qualitative interviews among mothers with and without a history of HDP. We also aimed to compare cardiovascular health (CVH) among mothers with vs without a prior history of HDP. METHODS: Women who were 3 to 7 years after childbirth completed baseline questionnaires (the Pittsburgh Sleep Quality Index [PSQI], Mediterranean Eating Pattern for Americans tool, and 7-item International Physical Activity Questionnaire) and wore the Oura ring continuously for 2 weeks to monitor sleep. Optimal sleep health was defined as a sleep duration of >/=7 hours, a PSQI score of 85%, and a sleep onset variability of <60 minutes. CVH was assessed using the Life's Essential 8 score, with 8 factors assessed via questionnaires (diet, physical activity, and nicotine exposure) and objective measurements (BMI, blood pressure, blood lipids, blood glucose, and sleep duration). Semistructured interviews were conducted. RESULTS: In total, among 49 women, 28 (57%) with prior HDP and 21 (43%) with prior normotensive pregnancy were included, with an average of 4.9 (SD 1.2) years after delivery. Average sleep quality was suboptimal in both groups (mean PSQI score 7.0, SD 3.5 in the HDP group vs mean PSQI score 5.9, SD 2.4 in the control group; P=.22). Average sleep duration was suboptimal (6.7, SD 0.8 hours), with no difference between groups. Approximately half (n=23, 47%) had abnormal sleep timing, which was more common among those with a prior normotensive pregnancy. Sleep onset variability was high (mean 1.2, SD 0.5 hours), with no significant differences by HDP status. The mean CVH score fell within the moderate range (70.7, SD 12.8), with no differences between groups. The components of the CVH score that were lowest (ie, worst) among the entire cohort were diet (mean 37.3, SD 25.6) and BMI (mean 50.8, SD 35.4 kg/m2). Common barriers to sleep included parenting, work, and household responsibilities. The study met our criteria for the feasibility and acceptability of using the Oura ring to study sleep in this population. CONCLUSIONS: Among postpartum women, sleep health was suboptimal regardless of HDP history. Interventions to improve sleep and CVH should target all mothers during the first decade after childbirth. CI - (c) Anais Hausvater, Elianna Shwayder, Marie-Pierre St-Onge, Linda G Kahn, Manuela Plazas-Montana, Lillian Na, Amanda Joa, Leonardo Trasande, Harmony R Reynolds. Originally published in JMIR Cardio (https://cardio.jmir.org). FAU - Hausvater, Anais AU - Hausvater A AUID- ORCID: 0000-0001-8649-9137 AD - Sarah Ross Soter Center for Women's Cardiovascular Research, Cardiovascular Clinical Research Center, Leon H Charney Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, 550 First Ave, New York, NY, 10016, United States, 1 6465012828. FAU - Shwayder, Elianna AU - Shwayder E AUID- ORCID: 0009-0004-1961-240X AD - Department of Medicine, Brigham and Women's Hospital, Boston, NY, United States. FAU - St-Onge, Marie-Pierre AU - St-Onge MP AUID- ORCID: 0000-0003-1354-1749 AD - Division of General Medicine and Center of Excellence for Sleep and Circadian Research, Columbia University Irving Medical Center, New York, NY, United States. FAU - Kahn, Linda G AU - Kahn LG AUID- ORCID: 0000-0002-6512-6160 AD - Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, United States. AD - Department of Population Health, New York University Grossman School of Medicine, New York, NY, United States. FAU - Plazas-Montana, Manuela AU - Plazas-Montana M AUID- ORCID: 0009-0002-6182-2481 AD - Sarah Ross Soter Center for Women's Cardiovascular Research, Cardiovascular Clinical Research Center, Leon H Charney Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, 550 First Ave, New York, NY, 10016, United States, 1 6465012828. FAU - Na, Lillian AU - Na L AUID- ORCID: 0009-0008-8702-5628 AD - Sarah Ross Soter Center for Women's Cardiovascular Research, Cardiovascular Clinical Research Center, Leon H Charney Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, 550 First Ave, New York, NY, 10016, United States, 1 6465012828. FAU - Joa, Amanda AU - Joa A AUID- ORCID: 0009-0008-7133-9307 AD - Sarah Ross Soter Center for Women's Cardiovascular Research, Cardiovascular Clinical Research Center, Leon H Charney Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, 550 First Ave, New York, NY, 10016, United States, 1 6465012828. FAU - Trasande, Leonardo AU - Trasande L AUID- ORCID: 0000-0002-1928-597X AD - Department of Pediatrics, New York University Grossman School of Medicine, New York, NY, United States. AD - Department of Population Health, New York University Grossman School of Medicine, New York, NY, United States. FAU - Reynolds, Harmony R AU - Reynolds HR AUID- ORCID: 0000-0003-0284-0655 AD - Sarah Ross Soter Center for Women's Cardiovascular Research, Cardiovascular Clinical Research Center, Leon H Charney Division of Cardiology, Department of Medicine, NYU Grossman School of Medicine, 550 First Ave, New York, NY, 10016, United States, 1 6465012828. LA - eng PT - Journal Article PT - Observational Study DEP - 20260526 PL - Canada TA - JMIR Cardio JT - JMIR cardio JID - 101718325 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Pilot Projects MH - Adult MH - *Hypertension, Pregnancy-Induced/physiopathology/epidemiology MH - *Cardiovascular Diseases/epidemiology/etiology/physiopathology MH - *Sleep/physiology MH - Surveys and Questionnaires MH - Sleep Quality MH - Sleep Duration MH - Risk Factors MH - *Sleep Wake Disorders/epidemiology PMC - PMC13211945 OTO - NOTNLM OT - cardiovascular health OT - digital health OT - hypertensive disorders of pregnancy OT - postpartum OT - sleep health OT - sleep quality COIS- Conflicts of Interest: None declared. EDAT- 2026/05/27 00:30 MHDA- 2026/05/27 00:31 PMCR- 2026/05/26 CRDT- 2026/05/26 18:22 PHST- 2025/07/22 00:00 [received] PHST- 2026/04/29 00:00 [revised] PHST- 2026/04/29 00:00 [accepted] PHST- 2026/05/27 00:31 [medline] PHST- 2026/05/27 00:30 [pubmed] PHST- 2026/05/26 18:22 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - v10i1e81118 [pii] AID - 81118 [pii] AID - 10.2196/81118 [doi] PST - epublish SO - JMIR Cardio. 2026 May 26;10:e81118. doi: 10.2196/81118. PMID- 42190578 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260706 IS - 1878-5506 (Electronic) IS - 1389-9457 (Linking) VI - 145 DP - 2026 Sep TI - The Italian registry for narcolepsy and central disorders of hypersomnolence (ReN&IS): Baseline clinical and diagnostic findings. PG - 109021 LID - S1389-9457(26)00260-1 [pii] LID - 10.1016/j.sleep.2026.109021 [doi] AB - OBJECTIVE: Central disorders of hypersomnolence, a wide and heterogeneous group of neurological disorders including narcolepsy type 1 (NT1), narcolepsy type 2 (NT2), and idiopathic hypersomnia (IH), are chronic, rare, under-recognized, and disabling conditions characterized by excessive daytime sleepiness (EDS) and other symptoms adversely impacting patients' lives. Large, harmonized real-world datasets are needed to improve phenotypic characterization, diagnostic accuracy, and translational research. METHODS: The Italian Registry for Narcolepsy and Central Disorders of Hypersomnolence (ReN&IS) is a national, multicenter, observational registry established in 2022. This preliminary analysis presents and compares demographic features, disease presentation, diagnostic assessment, medical comorbidities, current treatment patterns, and symptoms' evolution across diagnostic NT1, NT2, and IH groups of patients enrolled across 20 Italian referral centers. RESULTS: From March 2022 to September 2025, 480 cases were entered in the ReN&IS. NT1 accounted for 80.0% of cases, NT2 for 14.6%, and IH for 5.4%. NT1 showed younger age at onset and enrollment than NT2 and IH, as well as the highest burden of REM-sleep-related symptoms and clear biomarker profiles (HLA DQB1 *06:02 positivity and low cerebrospinal fluid orexin-A levels). Although most patients were treated with non-pharmacological (58-77%) and pharmacological (88-94%) interventions, residual EDS was common in the different groups (65-85%). Obesity and medical comorbidities, including cardiovascular, pulmonary, and connective tissue diseases did not significantly differ across groups. CONCLUSIONS: ReN&IS provides the first nationwide, real-world characterization of central disorders of hypersomnolence in Italy, highlighting diagnostic and therapeutic gaps, and offering a robust platform for future longitudinal and translational studies. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Torreri, Paola AU - Torreri P AD - National Center Rare Diseases - Istituto Superiore di Sanita, Rome, Italy. FAU - Buoncuore, Giorgia AU - Buoncuore G AD - National Center Rare Diseases - Istituto Superiore di Sanita, Rome, Italy. Electronic address: giorgia.buoncuore@iss.it. FAU - Rocchetti, Adele AU - Rocchetti A AD - National Center Rare Diseases - Istituto Superiore di Sanita, Rome, Italy. FAU - Facciaroni, Lorenzo AU - Facciaroni L AD - National Center Rare Diseases - Istituto Superiore di Sanita, Rome, Italy. FAU - Carta, Claudio AU - Carta C AD - National Center Rare Diseases - Istituto Superiore di Sanita, Rome, Italy. FAU - Pizza, Fabio AU - Pizza F AD - IRCCS - Institute of Neurological Science, Bologna, Italy; Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy. FAU - Vignatelli, Luca AU - Vignatelli L AD - IRCCS - Institute of Neurological Science, Bologna, Italy. FAU - Strambi, Luigi Ferini AU - Strambi LF AD - Sleep Disorders Center, Department of Neurology, Scientific Institute Ospedale San Raffaele, Vita-Salute University, Milan, Italy. FAU - Biscarini, Francesco AU - Biscarini F AD - IRCCS - Institute of Neurological Science, Bologna, Italy; Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy. FAU - Zenti, Massimo AU - Zenti M AD - Associazione Italiana Narcolettici e Ipersonni, AIN, Florence, Italy. FAU - Ferri, Raffaele AU - Ferri R AD - Sleep Research Centre, OASI Research Institute-IRCCS, Troina, Italy. FAU - Plazzi, Giuseppe AU - Plazzi G AD - IRCCS - Institute of Neurological Science, Bologna, Italy; Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy. CN - ReN&IS Group LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260518 PL - Netherlands TA - Sleep Med JT - Sleep medicine JID - 100898759 RN - Narcolepsy 1 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Comorbidity MH - *Idiopathic Hypersomnia/diagnosis/epidemiology MH - Italy/epidemiology MH - *Narcolepsy/diagnosis/epidemiology MH - *Registries OTO - NOTNLM OT - Biomarkers OT - Central disorders of hypersomnolence OT - Idiopathic hypersomnia OT - Narcolepsy type 1 OT - Narcolepsy type 2 OT - Registry COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. FIR - Angriman, Marco IR - Angriman M IRAD- South Tyrolean Healthcare Service, Ospedale Centrale di Bolzano, Bolzano, Italy. Electronic address: marco.angriman@sabes.it. FIR - Arico, Irene IR - Arico I IRAD- Sleep Medicine Center - Neurophysiopathology, AOU "G. Martino", Messina, Italy. Electronic address: irene.arico@polime.it. FIR - Arnaldi, Dario IR - Arnaldi D IRAD- Dept. of Neuroscience (DINOGMI) - Clinical Neurophysiology, IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy. Electronic address: dario.arnaldi@unige.it. FIR - Biscarini, Francesco IR - Biscarini F IRAD- Institute of Neurological Science, Bologna, Italy; Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy. Electronic address: francesco.biscarini2@unibo.it. FIR - Bonanni, Enrica IR - Bonanni E IRAD- Neurology Unit, Sleep Disorder Center - Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy. Electronic address: enrica.bonanni@unipi.it. FIR - Brunetti, Valerio IR - Brunetti V IRAD- UOC di Neurologia - Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. Electronic address: valerio.brunetti@policlinicogemelli.it. FIR - Buoncuore, Giorgia IR - Buoncuore G IRAD- National Center Rare Diseases - Istituto Superiore di Sanita, Rome, Italy. Electronic address: giorgia.buoncuore@iss.it. FIR - Francesca, Burrachi Torresi IR - Francesca BT IRAD- Neurology Unit, Sleep Disorder Center - Azienda Ospedaliero-Universitaria Pisana, Pisa, Italy. Electronic address: f.burrachitorresi@studenti.unipi.it. FIR - Canevini, Maria Paola IR - Canevini MP IRAD- Department of Health Sciences, University of Milan, Italy; Epilepsy Center - Sleep Medicine Center, Childhood and Adolescence Neuropsychiatry Unit, ASST Santi Paolo e Carlo, San Paolo Hospital, Milan, Italy. Electronic address: maria.canevini@asst-santipaolocarlo.it. FIR - Carta, Claudio IR - Carta C IRAD- National Center Rare Diseases - Istituto Superiore di Sanita, Rome, Italy. Electronic address: caudio.carta@iss.it. FIR - Cerroni, Gianluigi IR - Cerroni G IRAD- Center of Sleep Medicine, Dept. Neurology, Villa Serena Hospital, Citta S. Angelo, Pescara, Italy; Villaserena Foundation for the Research, Citta S. Angelo, Pescara, Italy. Electronic address: cerronigianluigi@gmail.com. FIR - Congiu, Patrizia IR - Congiu P IRAD- Department of Medical Sciences and Public Health, Interdipartimental Sleep Centre - University of Cagliari, Cagliari, Italy. Electronic address: patcongiu@gmail.com. FIR - Cosentino, Filomena I I IR - Cosentino FII IRAD- Sleep Research Centre, OASI Research Institute-IRCCS, Troina, Italy. Electronic address: nuccos3@gmail.com. FIR - Barbara, Costi Ilaria Rosa IR - Barbara CIR IRAD- Department of Neuroscience, Center of Sleep Medicine - Niguarda Hospital, Milan, Italy. Electronic address: ilariarosabarbara.costi@ospedaleniguarda.it. FIR - De Scisciolo, Martina IR - De Scisciolo M IRAD- UOC di Neurologia - Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. Electronic address: martinades1@hotmail.com. FIR - Di Giacomo, Roberta IR - Di Giacomo R IRAD- Epilepsy Unit, Sleep Disorders Unit - Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. Electronic address: roberta.digiacomo@istituto-besta.it. FIR - Didato, Giuseppe IR - Didato G IRAD- Epilepsy Unit, Sleep Disorders Unit - Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. Electronic address: giuseppe.didato@istituto-besta.it. FIR - Facciaroni, Lorenzo IR - Facciaroni L IRAD- National Center Rare Diseases - Istituto Superiore di Sanita, Rome, Italy. Electronic address: lorenzo.facciaroni@guest.iss.it. FIR - Ferini Strambi, Luigi IR - Ferini Strambi L IRAD- Sleep Disorders Center - Department of Neurology, Scientific Institute Ospedale San Raffaele, Vita-Salute University, Milan, Italy. Electronic address: ferinistrambi.luigi@hsr.it. FIR - Ferrazzoli, Chiara IR - Ferrazzoli C IRAD- Sleep Medicine Centre - Department of Systems Medicine, University Hospital of Rome "Tor Vergata", Rome, Italy. Electronic address: chiaraferrazzoli@gmail.com. FIR - Ferri, Raffaele IR - Ferri R IRAD- Sleep Research Centre, OASI Research Institute-IRCCS, Troina, Italy. Electronic address: rferri@oasi.en.it. FIR - Gnazzo, Martina IR - Gnazzo M IRAD- IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy; Clinic of Child and Adolescent Neuropsychiatry, Department of Mental Health, Physical and Preventive Medicine, University of Campania "Luigi Vanvitelli", Naples, Italy. Electronic address: martignazzo@hotmail.it. FIR - Guarnieri, Biancamaria IR - Guarnieri B IRAD- Center of Sleep Medicine, Dept. Neurology, Villa Serena Hospital, Citta S. Angelo, Pescara, Italy; Villaserena Foundation for the Research, Citta S. Angelo, Pescara, Italy. Electronic address: bmariaguarnieri@villaserena.it. FIR - Ingravallo, Francesca IR - Ingravallo F IRAD- Dipartimento di Scienze Mediche e Chirurgiche, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy. Electronic address: francesca.ingravallo@unibo.it. FIR - Lanuzza, Bartolo IR - Lanuzza B IRAD- Sleep Research Centre, OASI Research Institute-IRCCS, Troina, Italy. Electronic address: blanuzza@oasi.en.it. FIR - Lombardi, Carolina IR - Lombardi C IRAD- Center of Sleep Disorders, Department of Cardiovascular, Neural and Metabolic Sciences, Istituto Auxologico Italiano IRCCS, Milano, Italy; Dept of Medicine and Surgery, University of Milano-Bicocca, Milan, Italy. Electronic address: c.lombardi@auxologico.it. FIR - Longaretti, Francesca IR - Longaretti F IRAD- Child and Adolescence Neuropsychiatry Service, S. Croce and Carle Hospital, Cuneo, Italy. Electronic address: longaretti.f@ospedale.cuneo.it. FIR - Mattioli, Pietro IR - Mattioli P IRAD- Dept. of Neuroscience (DINOGMI) - Clinical Neurophysiology, IRCCS Azienda Ospedaliera Metropolitana, Genoa, Italy. Electronic address: pietro.mattioli@aomliguria.it. FIR - Mattaliano, Paola IR - Mattaliano P IRAD- Center of Sleep Disorders, Department of Cardiovascular, Neural and Metabolic Sciences, Istituto Auxologico Italiano Milan, Italy. Electronic address: p.mattaliano@auxologico.it. FIR - Menna, Elisa IR - Menna E IRAD- South Tyrolean Healthcare Service, Ospedale Centrale di Bolzano, Bolzano, Italy. Electronic address: elisa.menna@sabes.it. FIR - Nobili, Lino IR - Nobili L IRAD- UOC Neuropsichiatria Infantile, IRCCS Istituto G. Gaslini, Italy; DINOGMI, University of Genoa, Genoa, Italy. Electronic address: lino.nobili@unige.it. FIR - Pizza, Fabio IR - Pizza F IRAD- Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy; IRCCS - Institute of Neurological Science, Bologna, Italy. Electronic address: fabio.pizza@unibo.it. FIR - Placidi, Fabio IR - Placidi F IRAD- Sleep Medicine Centre - Department of Systems Medicine, University Hospital of Rome "Tor Vergata", Rome, Italy. Electronic address: fabio.placidi@uniroma2.it. FIR - Plazzi, Giuseppe IR - Plazzi G IRAD- Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, Italy; IRCCS - Institute of Neurological Science, Bologna, Italy. Electronic address: giuseppe.plazzi@unibo.it. FIR - Podesta, Barbara IR - Podesta B IRAD- Child and Adolescence Neuropsychiatry Service, S. Croce and Carle Hospital, Cuneo, Italy. Electronic address: podesta.b@ospedale.cuneo.it. FIR - Puligheddu, Monica IR - Puligheddu M IRAD- Department of Medical Sciences and Public Health, Interdipartimental Sleep Centre - University of Cagliari, Cagliari, Italy. Electronic address: puligheddu@unica.it. FIR - Rocchetti, Adele IR - Rocchetti A IRAD- National Center Rare Diseases - Istituto Superiore di Sanita, Rome, Italy. Electronic address: adele.rocchetti@iss.it. FIR - Romigi, Andrea IR - Romigi A IRAD- Departmental Faculty of Medicine, IRCCS Neuromed Istituto Neurologico Mediterraneo, Pozzilli, IS, Italy; UniCamillus, Rome, Italy. Electronic address: andrea.romigi@neuromed.it. FIR - Savarese, Maria Antonietta IR - Savarese MA IRAD- Centro Dei Disturbi Del Sonno, AOU Policlinico di Bari, Bari, Italy. Electronic address: centrosonno.neurologia@uniba.it. FIR - Silvestri, Rosalia IR - Silvestri R IRAD- Sleep Medicine Center - Neurophysiopathology, AOU "G. Martino", Messina, Italy. Electronic address: rosalia.silvestri@unime.it. FIR - Solbiati, Michela IR - Solbiati M IRAD- Unit of Sleep Medicine and Epilepsy, IRCCS C. Mondino Foundation, Pavia, Italy. Electronic address: michela.solbiati01@universitadipavia.it. FIR - Terzaghi, Michele IR - Terzaghi M IRAD- Unit of Sleep Medicine and Epilepsy, IRCCS C. Mondino Foundation, Pavia, Italy. Electronic address: michele.terzaghi@mondino.it. FIR - Torreri, Paola IR - Torreri P IRAD- National Center Rare Diseases - Istituto Superiore di Sanita, Rome, Italy. Electronic address: paola.torreri@iss.it. FIR - Veneruso, Marco IR - Veneruso M IRAD- UOC Neuropsichiatria Infantile, IRCCS Istituto G. Gaslini, Italy; DINOGMI, University of Genoa, Genoa, Italy. Electronic address: marc.veneruso@gmail.com. FIR - Vignatelli, Luca IR - Vignatelli L IRAD- IRCCS - Institute of Neurological Science, Bologna, Italy. Electronic address: l.vignatelli@ausl.bologna.it. FIR - Zambrelli, Elena IR - Zambrelli E IRAD- Epilepsy Center - Sleep Medicine Center - ASST Santi Paolo e Carlo, San Paolo Hospital, Milan, Italy. Electronic address: elena.zambrelli@asst-santipaolocarlo.it. FIR - Zenti, Massimo IR - Zenti M IRAD- Associazione Italiana Narcolettici e Ipersonni (AIN), Florence, Italy. Electronic address: massimo.zenti@gmail.com. EDAT- 2026/05/27 00:30 MHDA- 2026/06/13 06:37 CRDT- 2026/05/26 18:10 PHST- 2026/03/13 00:00 [received] PHST- 2026/04/28 00:00 [revised] PHST- 2026/05/14 00:00 [accepted] PHST- 2026/06/13 06:37 [medline] PHST- 2026/05/27 00:30 [pubmed] PHST- 2026/05/26 18:10 [entrez] AID - S1389-9457(26)00260-1 [pii] AID - 10.1016/j.sleep.2026.109021 [doi] PST - ppublish SO - Sleep Med. 2026 Sep;145:109021. doi: 10.1016/j.sleep.2026.109021. Epub 2026 May 18. PMID- 42190145 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260926 IS - 1526-632X (Electronic) IS - 0028-3878 (Print) IS - 0028-3878 (Linking) VI - 106 IP - 12 DP - 2026 Jun 23 TI - A Validated Prognostic Score for Time to Loss of Ambulation in Patients With Duchenne Muscular Dystrophy. PG - e214705 LID - 10.1212/WNL.0000000000214705 [doi] LID - e214705 AB - BACKGROUND AND OBJECTIVES: Development of a prognostic score for time to loss of ambulation (LoA) may help guide treatment of patients with Duchenne muscular dystrophy (DMD). Information from clinical data sources was used to create a prognostic score for LoA for use in practice. METHODS: Data used included 4 natural history databases and 3 clinical trial placebo arms. Inclusion criteria were as follows: (1) 6-minute walk distance >/=75 m; (2) a subsequent visit with an outcome assessment that identified LoA; (3) current corticosteroid use; and (4) available data on prognostic factors. Classification and regression tree models for time to LoA were used to classify patients into 5 risk groups (group 5 = highest risk), prioritizing the easily obtained rise from floor (RFF) and 10-m walk/run (10MWR) times as predictors. The prognostic score was validated in the Cooperative International Neuromuscular Research Group data. RESULTS: Data from 608 boys were analyzed (mean age 9.1 years). Kaplan-Meier curves for time to LoA for each risk group were well separated, describing meaningful differences in time to LoA. Median time to LoA for risk group 1 was not reached during a median of 2.0 years of follow-up. Median times to LoA for risk groups 2-5 were 4.4 (95% CI 4.0-inf), 3.0 (2.1-4.1), 2.0 (1.6-2.1), and 0.9 (0.8-1.6) years, respectively. These risk groups showed concordant times to LoA among 226 patients in the validation data and provided finer separation of patients across different levels of LoA risk than thresholds based on individual functional tests. DISCUSSION: Patients with DMD were classified into 5 risk groups for LoA using a simple, easy-to-use prognostic score based on RFF and 10MWR thresholds. The prognostic score replicated well in validation data and performed better than previously proposed classifications used in practice. Incorporating the prognostic score for time to LoA into a clinical visit may allow clinicians to counsel patients on trial eligibility, need for mobility devices, home adjustments, financial accommodations, and psychosocial needs. The prognostic score may also be used in trials to inform inclusion criteria and stratification. Study limitations included limited data for prediction of LoA risk beyond 4 years. FAU - McDonald, Craig M AU - McDonald CM AUID- ORCID: 0000-0002-8779-3220 AD - Department of Physical Medicine and Rehabilitation and Department of Pediatrics, University of California Davis Health, The Cooperative International Neuromuscular Research Group, Sacramento, CA. FAU - Signorovitch, James AU - Signorovitch J AD - Analysis Group, Inc., Boston, MA. AD - Collaborative Trajectory Analysis Project, Cambridge, MA. FAU - Goemans, Nathalie Marie AU - Goemans NM AUID- ORCID: 0000-0002-5157-7155 AD - Child Neurology, University Hospitals Leuven, Leuven, Belgium. FAU - Mercuri, Eugenio AU - Mercuri E AUID- ORCID: 0000-0002-9851-5365 AD - Child Neurology Unit e Centro Nemo, IRCCS Fondazione Policlinico Gemelli, Universita Cattolica del Sacro Cuore, Rome, Italy. FAU - Gordish-Dressman, Heather AU - Gordish-Dressman H AUID- ORCID: 0000-0002-2330-5427 AD - Department of Physical Medicine and Rehabilitation and Department of Pediatrics, University of California Davis Health, The Cooperative International Neuromuscular Research Group, Sacramento, CA. AD - Children's National Hospital, Washington, DC. FAU - Vandenborne, Krista AU - Vandenborne K AD - University of Florida, Gainseville, FL. FAU - Sajeev, Gautam AU - Sajeev G AUID- ORCID: 0000-0002-1827-8938 AD - Analysis Group, Inc., Boston, MA. FAU - Ward, Susan J AU - Ward SJ AD - Collaborative Trajectory Analysis Project, Cambridge, MA. FAU - Fillbrunn, Mirko AU - Fillbrunn M AD - Analysis Group, Inc., Boston, MA. FAU - Frean, Molly AU - Frean M AUID- ORCID: 0000-0002-5770-4266 AD - Analysis Group, Inc., Boston, MA. FAU - Servais, Laurent AU - Servais L AUID- ORCID: 0000-0001-9270-4061 AD - MDUK Oxford Neuromuscular Centre, Department of Paediatrics, University of Oxford and NIHR Oxford Biomedical Research Center, United Kingdom. AD - Neuromuscular Center of Liege, Division of Paediatrics, CHU and University of Liege, Belgium. FAU - Niks, Erik H AU - Niks EH AUID- ORCID: 0000-0001-5892-5143 AD - Department of Neurology, Leiden University Medical Center, the Netherlands. FAU - Straub, Volker AU - Straub V AUID- ORCID: 0000-0001-9046-3540 AD - John Walton Muscular Dystrophy Research Centre, Newcastle University and Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom. FAU - De Groot, Imelda J M AU - De Groot IJM AUID- ORCID: 0000-0003-1634-1427 AD - Department of Rehabilitation, Donders Centre of Neuroscience, Radboud University Nijmegen Medical Center, the Netherlands; and. FAU - Muntoni, Francesco AU - Muntoni F AUID- ORCID: 0000-0002-9102-5232 AD - UCL Great Ormond Street Institute of Child Health and Biomedical Research Centre, London, United Kingdom. CN - iMDEX, for the PRO-DMD-01 Study, ImagingDMD, CINRG DNHS, and Universitaire Ziekenhuizen Leuven Group LA - eng PT - Journal Article DEP - 20260526 PL - United States TA - Neurology JT - Neurology JID - 0401060 SB - IM CIN - Neurology. 106:e214882. PMID: 42190149 MH - Humans MH - *Muscular Dystrophy, Duchenne/diagnosis/physiopathology MH - Male MH - Prognosis MH - *Walking/physiology MH - Child MH - Adolescent MH - Time Factors MH - Kaplan-Meier Estimate PMC - PMC13312938 EDAT- 2026/05/26 23:33 MHDA- 2026/05/27 00:30 PMCR- 2026/05/26 CRDT- 2026/05/26 16:02 PHST- 2026/05/27 00:30 [medline] PHST- 2026/05/26 23:33 [pubmed] PHST- 2026/05/26 16:02 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - WNL-2025-204418 [pii] AID - 10.1212/WNL.0000000000214705 [doi] PST - ppublish SO - Neurology. 2026 Jun 23;106(12):e214705. doi: 10.1212/WNL.0000000000214705. Epub 2026 May 26. PMID- 42189299 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20261010 IS - 1573-7373 (Electronic) IS - 0167-594X (Linking) VI - 178 IP - 1 DP - 2026 May 26 TI - Role of tumor momentum in neurocognitive deficits among pediatric brainstem glioma prior to treatment: a pilot study. LID - 23 [pii] LID - 10.1007/s11060-026-05644-x [doi] AB - PURPOSE: To investigate the association between tumor momentum indices and pretreatment neurocognitive function in children with brainstem gliomas (BSGs), and to evaluate their prognostic value for overall survival (OS). METHODS: This prospective pilot study enrolled 34 treatment-naive children with histopathologically confirmed BSGs and 30 age-matched healthy controls at Beijing Tiantan Hospital, Capital Medical University. Neurocognitive function was assessed using the Wechsler Intelligence Scale for Children-Fourth Edition (WISC-IV), and emotional-behavioral performance was screened with the Child Behavior Checklist (CBCL). Tumor momentum was characterized by the MRS-derived Cho/Cr ("image momentum") and the Ki-67 proliferative index ("pathological momentum"). Kaplan-Meier analysis was performed to evaluate OS. RESULTS: Patients scored significantly lower than controls across all WISC-IV composite scores and subtests (p < 0.001). The Cho/Cr ratio was inversely correlated with verbal comprehension (rho = -0.412, p = 0.015) and independently predicted potential verbal function deficit (OR = 4.281, 95% CI 1.146-15.994, p = 0.031). The Ki-67 index was positively associated with CBCL attention problems in high- versus low-Ki-67 subgroups (p = 0.036). Ki-67 was significantly associated with OS (p = 0.027), whereas neither Cho/Cr nor baseline cognitive status demonstrated prognostic value. CONCLUSION: Our study provides the first direct evidence that treatment-naive children with BSGs harbor significant neurocognitive impairment assessed by a standardized intelligence scale. The Cho/Cr ratio and the Ki-67 index capture complementary dimensions of tumor biology: the former may serve as a non-invasive biomarker for cognitive risk stratification, while the latter retains its established prognostic value for survival. CI - (c) 2026. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Mai, Yi-Ying AU - Mai YY AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. AD - Department of Neurosurgery, Xuanwu Hospital, International Neuroscience Institute, Capital Medical University, Beijing, 100053, China. FAU - Liu, Zhi-Ming AU - Liu ZM AUID- ORCID: 0000-0002-4030-862X AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. FAU - Zhou, Hang AU - Zhou H AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. FAU - Jiang, Kai AU - Jiang K AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. FAU - Jia, He-Yuan AU - Jia HY AD - School of Instrumentation and Optoelectronic Engineering, Beihang University, Beijing, China. jhy13161190599@163.com. FAU - Zhang, Peng AU - Zhang P AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. zhangpeng@bjtth.org. FAU - Zhang, Li-Wei AU - Zhang LW AUID- ORCID: 0000-0003-1919-3765 AD - Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. zhangliweittyy@163.com. AD - Beijing Neurosurgical Institute, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, China. zhangliweittyy@163.com. LA - eng GR - 2021ZD0200201/Science and Technology Innovation 2030-Brain Science and Brain-Inspired Intelligence Project of China/ GR - JYY2018-7/Beijing Municipal Public Welfare Development and Reform Pilot Project for Medical Research Institutes/ PT - Journal Article DEP - 20260526 PL - United States TA - J Neurooncol JT - Journal of neuro-oncology JID - 8309335 RN - 0 (Ki-67 Antigen) RN - 0 (Biomarkers, Tumor) SB - IM MH - Prospective Studies MH - Pilot Projects MH - *Neurocognitive Disorders/epidemiology/etiology MH - *Glioma/metabolism/pathology/psychology MH - *Brain Stem Neoplasms/metabolism/pathology/psychology MH - Prognosis MH - Case-Control Studies MH - Intelligence Tests MH - Ki-67 Antigen/metabolism MH - Neuropsychological Tests MH - Risk Factors MH - *Biomarkers, Tumor/metabolism MH - *Tumor Burden/physiology MH - Humans MH - Male MH - Female MH - Child MH - Adolescent MH - Follow-Up Studies MH - Predictive Value of Tests OTO - NOTNLM OT - Brainstem glioma OT - Ki-67 OT - Magnetic resonance spectroscopy OT - Neurocognitive deficit OT - Tumor momentum COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Beijing Tiantan Hospital, Capital Medical University (KY 2020-087-02). Consent to participate: Informed consent was obtained from all participants and their legal guardians included in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/05/26 17:42 MHDA- 2026/05/26 23:33 CRDT- 2026/05/26 11:18 PHST- 2026/03/17 00:00 [received] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/05/26 23:33 [medline] PHST- 2026/05/26 17:42 [pubmed] PHST- 2026/05/26 11:18 [entrez] AID - 10.1007/s11060-026-05644-x [pii] AID - 10.1007/s11060-026-05644-x [doi] PST - epublish SO - J Neurooncol. 2026 May 26;178(1):23. doi: 10.1007/s11060-026-05644-x. PMID- 42189092 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260730 IS - 2153-2176 (Electronic) IS - 2153-2168 (Linking) VI - 22 IP - 6 DP - 2026 Sep TI - A Qualitative Assessment of Preoperative Educational Needs Among Adolescent Metabolic and Bariatric Surgery Patients and Parents or Guardians. PG - 359-366 LID - 10.1177/21532176261453154 [doi] AB - BACKGROUND: Metabolic and bariatric surgery (MBS) is a safe and effective treatment option for adolescents with severe obesity; however, some health care providers are hesitant to refer adolescents due to concerns regarding decisional capacity. Structured educational materials provided prior to MBS have the potential to improve informed decision-making. The objective of this study was to characterize topics that may not be adequately addressed in existing structured educational materials for adolescents seeking MBS. METHODS: Semi-structured, qualitative interviews were conducted with adolescents who had undergone MBS and with parents or guardians of postoperative adolescents. Thematic saturation was assessed by considering properties from a base number of interviews (n = 7) and a run length (n = 2). Interrater reliability was established at the theme level. An adolescent citizen scientist was approached to provide feedback on the codebook. RESULTS: In total, six adolescents and six parents or guardians diverse in race and ethnicity were interviewed. For adolescents, the average age at the time of the procedure was 16 years (standard deviation = 2.37). Most participants (n = 5) underwent vertical sleeve gastrectomy. Five key themes were identified that provide additional information on the preferred format of delivery (interactive materials, teen-specific materials) and topics that may not be adequately addressed (physical aspects of surgery, psychosocial well-being, and specific resources for parents or guardians). CONCLUSIONS: This current study identified gaps in the format of delivery and topics covered in structured preoperative educational materials. Future work should determine if these gaps are widespread across accredited MBS centers. Furthermore, the development of additional materials should be considered. FAU - Heeren, Faith Anne N AU - Heeren FAN AUID- ORCID: 0000-0002-6819-8258 AD - Department of Health Outcomes and Biomedical Informatics, University of Florida College of Medicine, Gainesville, Florida, USA. FAU - Bylund, Carma L AU - Bylund CL AD - Department of Health Outcomes and Biomedical Informatics, University of Florida College of Medicine, Gainesville, Florida, USA. FAU - Menon, Sarada AU - Menon S AD - College of Medicine, University of Oklahoma, Oklahoma City, Oklahoma, USA. FAU - Dwaram, Nehal AU - Dwaram N AD - Department of Health Outcomes and Biomedical Informatics, University of Florida College of Medicine, Gainesville, Florida, USA. FAU - Gilbert, Ashton AU - Gilbert A AD - Cauble School of Nursing and Health Sciences, Reinhardt University, Waleska, Georgia, USA. FAU - Lemas, Dominick J AU - Lemas DJ AD - Department of Health Outcomes and Biomedical Informatics, University of Florida College of Medicine, Gainesville, Florida, USA. FAU - Ayzengart, Alexander AU - Ayzengart A AD - Department of Surgery, Renown Health, Reno, Nevada, USA. FAU - Janicke, David AU - Janicke D AD - Department of Clinical and Health Psychology, University of Florida College of Public Health and Health Professions, Gainesville, Florida, USA. FAU - Cardel, Michelle I AU - Cardel MI AD - Department of Health Outcomes and Biomedical Informatics, University of Florida College of Medicine, Gainesville, Florida, USA. AD - WW International Inc., New York, New York, USA. LA - eng PT - Journal Article DEP - 20260526 PL - United States TA - Child Obes JT - Childhood obesity (Print) JID - 101542497 SB - IM MH - Humans MH - *Bariatric Surgery MH - Adolescent MH - Female MH - *Parents/education/psychology MH - Male MH - *Patient Education as Topic/methods MH - *Pediatric Obesity/surgery/psychology MH - Qualitative Research MH - *Preoperative Care MH - *Needs Assessment MH - *Obesity, Morbid/surgery OTO - NOTNLM OT - clinical counseling OT - community-engaged OT - patient-centered care OT - shared-decision making COIS- Author Disclosure StatementF.A.N.H. reports serving on the Obesity Society's Finance Committee, consulting fees from WW, receiving an honorarium for speaking from the American Academy of Pediatrics, institutional support for travel, and membership on the Obesity Action Coalition's Membership and Access to Care committees, outside the scope of the submitted work. M.I.C. is a shareholder and employee of WW International Inc. EDAT- 2026/05/26 17:41 MHDA- 2026/07/30 06:41 CRDT- 2026/05/26 10:52 PHST- 2026/07/30 06:41 [medline] PHST- 2026/05/26 17:41 [pubmed] PHST- 2026/05/26 10:52 [entrez] AID - 10.1177/21532176261453154 [doi] PST - ppublish SO - Child Obes. 2026 Sep;22(6):359-366. doi: 10.1177/21532176261453154. Epub 2026 May 26. PMID- 42189046 OWN - NLM STAT- MEDLINE DCOM- 20260703 LR - 20260929 IS - 2153-2176 (Electronic) IS - 2153-2168 (Linking) VI - 22 IP - 5 DP - 2026 Jul TI - Interactive Text Messaging to Promote Responsive Bottle-Feeding Among Mothers of Infants Enrolled in the Special Supplemental Nutrition Program for Women, Infants and Children: A 12-Week Randomized Attention Control Trial. PG - 320-333 LID - 10.1177/21532176261450308 [doi] AB - BACKGROUND: Responsive feeding supports healthy growth and may reduce obesity risk, yet bottle-feeding can promote nonresponsive feeding practices such as pressuring infants to finish their bottle. Because the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) serves many U.S. infants and bottle-feeding is common, scalable strategies are needed. We tested feasibility, acceptability, and preliminary effectiveness of GrowWell, an automated text-messaging program to support responsive bottle-feeding. METHODS: We conducted a 12-week randomized attention-control trial among mothers of bottle-fed infants /=80% agreement across items), with consistently higher ratings in the intervention group. Overall changes in IFSQ scores did not differ between groups (n = 58, 31 intervention, 27 control); however, within-group analyses showed reductions in pressuring to finish (p = 0.012) and pressuring to soothe (p = 0.002) among intervention participants at 12 weeks. Exploratory interaction analyses suggested heterogeneity by select sociodemographic characteristics. Interviews among intervention participants (n = 16) indicated high satisfaction, increased awareness of cues, and adoption of responsive practices. CONCLUSIONS: GrowWell was feasible and highly acceptable, with promising preliminary signals for reducing pressuring bottle-feeding practices. FAU - Kay, Melissa C AU - Kay MC AUID- ORCID: 0000-0002-9695-3126 AD - Wake Forest University School of Medicine, Winston-Salem, NC, USA. FAU - Richardson, Taylor N AU - Richardson TN AD - College of Nursing, East Carolina University, Greenville, NC, USA. FAU - Bell, Lucy AU - Bell L AD - Wake Forest University School of Medicine, Winston-Salem, NC, USA. FAU - Shelton, Sarah M AU - Shelton SM AUID- ORCID: 0009-0002-2517-1722 AD - Wake Forest University School of Medicine, Winston-Salem, NC, USA. FAU - Wasser, Heather AU - Wasser H AD - University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. LA - eng GR - KL2 TR002554/TR/NCATS NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial DEP - 20260526 PL - United States TA - Child Obes JT - Childhood obesity (Print) JID - 101542497 SB - IM MH - Humans MH - Female MH - Infant MH - *Bottle Feeding/statistics & numerical data/psychology MH - *Text Messaging MH - *Mothers/psychology/education MH - *Food Assistance MH - Adult MH - Male MH - Infant, Newborn MH - *Health Promotion/methods MH - United States MH - Feasibility Studies MH - Feeding Behavior MH - Pediatric Obesity/prevention & control OTO - NOTNLM OT - WIC OT - bottle-feeding OT - responsive feeding OT - text messaging COIS- Author Disclosure StatementThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/05/26 17:41 MHDA- 2026/07/03 22:38 CRDT- 2026/05/26 10:33 PHST- 2026/07/03 22:38 [medline] PHST- 2026/05/26 17:41 [pubmed] PHST- 2026/05/26 10:33 [entrez] AID - 10.1177/21532176261450308 [doi] PST - ppublish SO - Child Obes. 2026 Jul;22(5):320-333. doi: 10.1177/21532176261450308. Epub 2026 May 26. PMID- 42188566 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260526 LR - 20260813 IS - 2075-4663 (Electronic) IS - 2075-4663 (Linking) VI - 14 IP - 5 DP - 2026 May 6 TI - Preliminary Evidence of Motor Outcomes in Children with Autism Spectrum Disorder Following Equine-Assisted Therapy and Dual-Task Training: A Pilot Study. LID - 10.3390/sports14050190 [doi] LID - 190 AB - BACKGROUND: Equine-assisted therapy (EAT) is a supportive intervention for children with autism spectrum disorder (ASD). AIM: This pilot study evaluated the feasibility of a cognitive-motor EAT intervention to explore its preliminary effects on motor coordination in children with ASD. METHODS: A single-group pre-test-post-test design was adopted. Twelve children (mean age: 10.08 +/- 1.51 years; ASD level 1-2) participated in a 16-week EAT program. The intervention integrated EAT with cognitive dual-task activities targeting attention and perceptual processing. Motor performance was assessed before and after the intervention using the Movement Assessment Battery for Children (MABC-2). RESULTS: The RM-ANOVA examined pre-post changes. A significant improvement in the MABC-2 Total Test Score was observed (p = 0.036; etap(2) = 0.34; 95% CI [0.541, 13.792]), indicating a trend of improvement of global motor coordination. No significant improvements were observed in Manual Dexterity, Aiming and Catching, and Balance subscale scores. CONCLUSIONS: A cognitively enriched EAT program promoted improvements in overall motor competence in ASD children, even without measurable changes in specific motor skills. The intervention was feasible and well-tolerated, with high adherence and no adverse events. These preliminary findings support the feasibility and potential value of integrating cognitive-motor demands into EAT and provide a rationale for larger randomized controlled studies. FAU - Della Valle, Carlo AU - Della Valle C AUID- ORCID: 0009-0004-5345-0045 AD - Department of Neurosciences, Biomedicine and Movement, University of Verona, 37314 Verona, Italy. AD - Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy. FAU - Di Martino, Giulia AU - Di Martino G AUID- ORCID: 0000-0003-1468-7491 AD - Department of Human Sciences, Guglielmo Marconi University, 00193 Rome, Italy. FAU - Melis, Alessio AU - Melis A AD - Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy. FAU - Persichini, Lorenzo AU - Persichini L AD - Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy. FAU - De Santis Del Tavano, Chiara AU - De Santis Del Tavano C AD - ASD Sociale "Il Giardino di Filippo-Agriland", 01100 Viterbo, Italy. FAU - Cerulli, Claudia AU - Cerulli C AUID- ORCID: 0000-0003-2637-7968 AD - Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy. FAU - Fiorilli, Giovanni AU - Fiorilli G AUID- ORCID: 0000-0002-3786-7818 AD - Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy. FAU - Calcagno, Giuseppe AU - Calcagno G AUID- ORCID: 0000-0003-4680-1535 AD - Department of Medicine and Health Sciences, University of Molise, 86100 Campobasso, Italy. FAU - Iuliano, Enzo AU - Iuliano E AD - Department of Theoretical and Applied Sciences, eCampus University, 22060 Novedrate, Italy. FAU - di Cagno, Alessandra AU - di Cagno A AUID- ORCID: 0000-0003-4517-3100 AD - Department of Human Sciences, Guglielmo Marconi University, 00193 Rome, Italy. AD - Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", 00135 Rome, Italy. LA - eng PT - Journal Article DEP - 20260506 PL - Switzerland TA - Sports (Basel) JT - Sports (Basel, Switzerland) JID - 101722684 PMC - PMC13210957 OTO - NOTNLM OT - autism OT - cognitive-motor intervention OT - executive function OT - hippotherapy OT - motor skills OT - physical activity COIS- The authors declare no conflicts of interest. EDAT- 2026/05/26 17:41 MHDA- 2026/05/26 17:42 PMCR- 2026/05/06 CRDT- 2026/05/26 09:53 PHST- 2026/02/05 00:00 [received] PHST- 2026/04/02 00:00 [revised] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/05/26 17:42 [medline] PHST- 2026/05/26 17:41 [pubmed] PHST- 2026/05/26 09:53 [entrez] PHST- 2026/05/06 00:00 [pmc-release] AID - sports14050190 [pii] AID - sports-14-00190 [pii] AID - 10.3390/sports14050190 [doi] PST - epublish SO - Sports (Basel). 2026 May 6;14(5):190. doi: 10.3390/sports14050190. PMID- 42188554 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260526 LR - 20260813 IS - 2075-4663 (Electronic) IS - 2075-4663 (Linking) VI - 14 IP - 5 DP - 2026 Apr 29 TI - Construction and Validation of a Specific Balance Test for Rhythmic Gymnasts: A Pilot Study. LID - 10.3390/sports14050178 [doi] LID - 178 AB - BACKGROUND: Balance is a key ability in rhythmic gymnastics, affecting not only technical performance but also the aesthetic and expressive quality of routines. Standard tests often do not reflect the real demands of the sport, where gymnasts must simultaneously maintain stability, manipulate apparatus, and follow the musical rhythm. Therefore, there is a need for a specific test that combines motor and cognitive challenges to provide a precise and reliable assessment of athletes' functional abilities. METHODS: The study involved 12 girls with an average age of 9 years. Participants underwent anthropometric measurements and were tested using standard motor tests as well as a specific balance test for rhythmic gymnasts (BTRG). Test reliability was assessed using a test-retest procedure, and construct validity was evaluated through factor analysis in comparison with existing balance tests. RESULTS: The BTRG demonstrated high reliability (ICC = 0.96; CV = 6.4%; SEM = 0.18) and the ability to distinguish gymnasts from different programs. Factor analysis confirmed that the BTRG effectively measures specific balance in accordance with theoretical expectations. CONCLUSIONS: The new test provides a potentially valid and reliable tool for assessing specific balance in rhythmic gymnasts and maybe useful in the training process, athlete evaluation, and talent development; however, these finding should be interpreted with caution as they are preliminary and derived from pilot study. FAU - Stojkovic, Rebeka AU - Stojkovic R AD - Faculty of Kinesiology, University of Josip Juraj Strossmayer in Osijek, Drinska 16a, 31000 Osijek, Croatia. FAU - Peric, Ivan AU - Peric I AUID- ORCID: 0000-0002-4897-0925 AD - Faculty of Kinesiology, University of Josip Juraj Strossmayer in Osijek, Drinska 16a, 31000 Osijek, Croatia. FAU - Tomac, Zvonimir AU - Tomac Z AD - Faculty of Kinesiology, University of Josip Juraj Strossmayer in Osijek, Drinska 16a, 31000 Osijek, Croatia. FAU - Ajman, Hrvoje AU - Ajman H AUID- ORCID: 0000-0003-3663-4008 AD - Faculty of Kinesiology, University of Josip Juraj Strossmayer in Osijek, Drinska 16a, 31000 Osijek, Croatia. FAU - Spoljaric, Zoran AU - Spoljaric Z AD - Faculty of Kinesiology, University of Josip Juraj Strossmayer in Osijek, Drinska 16a, 31000 Osijek, Croatia. LA - eng PT - Journal Article DEP - 20260429 PL - Switzerland TA - Sports (Basel) JT - Sports (Basel, Switzerland) JID - 101722684 PMC - PMC13210542 OTO - NOTNLM OT - balance assessment OT - construct validity OT - reliability OT - rhythmic gymnastics OT - sport-specific testing COIS- The authors declare no conflicts of interest. EDAT- 2026/05/26 17:42 MHDA- 2026/05/26 17:43 PMCR- 2026/04/29 CRDT- 2026/05/26 09:53 PHST- 2026/03/07 00:00 [received] PHST- 2026/04/20 00:00 [revised] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/05/26 17:43 [medline] PHST- 2026/05/26 17:42 [pubmed] PHST- 2026/05/26 09:53 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - sports14050178 [pii] AID - sports-14-00178 [pii] AID - 10.3390/sports14050178 [doi] PST - epublish SO - Sports (Basel). 2026 Apr 29;14(5):178. doi: 10.3390/sports14050178. PMID- 42188085 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260526 LR - 20260813 IS - 2308-3425 (Electronic) IS - 2308-3425 (Linking) VI - 13 IP - 5 DP - 2026 May 7 TI - The FOOTLOOSE App: Evaluation of a Gamified App-Based Exercise Intervention for Children and Adolescents with Congenital Heart Disease-A Mixed-Methods Feasibility Study. LID - 10.3390/jcdd13050199 [doi] LID - 199 AB - BACKGROUND: A physically active lifestyle is crucial for long-term cardiovascular health; however, access to supervised exercise programs for children and adolescents with congenital heart disease (CHD) remains limited. Although prior digital exercise interventions for this population have demonstrated safety and feasibility, adherence has often been low. Mobile health approaches integrating gamification may enhance motivation and engagement, particularly among young "digital natives." FOOTLOOSE is an app-based home exercise program developed specifically for children and adolescents with CHD. This study aimed to evaluate user experience, usability, and perceived impact using a multimethod approach. METHODS: Children and adolescents aged 10-18 years with simple, moderate, or complex CHD were recruited between July and December 2025 mainly during routine outpatient visits at the TUM Klinikum Deutsches Herzzentrum. Participants used the FOOTLOOSE app in their daily lives over a two-week period. Evaluation included semi-structured qualitative interviews and standardized questionnaires assessing physical activity self-efficacy, enjoyment of physical activity (PACES-S), user experience (UEQ), and health-related quality of life (KINDL((R))). Interviews were conducted digitally, transcribed verbatim, and analyzed using qualitative content analysis according to Kuckartz until thematic saturation was reached. RESULTS: A total of 22 participants (mean age 13.4 +/- 2.3 years; 54.5% female) were included. Overall, the FOOTLOOSE app was perceived positively, with participants highlighting enjoyment, intuitive usability, and personalized workout creation. Participants contributed diverse and creative suggestions for further app development, particularly regarding more advanced gamification features (e.g., games or rankings). Most participants reported self-perceived increase in physical activity during the intervention period (n = 15). UEQ scores (mean +/- SD) were as follows: attractiveness (1.3 +/- 0.8), perspicuity (1.7 +/- 1.1), efficiency (1.2 +/- 0.9), dependability (1.4 +/- 0.7), stimulation (1.0 +/- 1.1), and novelty (0.6 +/- 1.0). CONCLUSIONS: This study demonstrates the feasibility and user acceptance of a gamified, app-based home exercise program for children and adolescents with CHD. User-centered feedback highlights important directions for iterative refinement, particularly regarding age-appropriate and engaging gamification elements. These findings provide a foundation for future studies evaluating long-term engagement and effectiveness in larger samples. FAU - Schoneburg, Charlotte AU - Schoneburg C AD - Institute of Preventive Pediatrics, Technische Universitat Munchen, 80809 Munchen, Germany. AD - Department of Congenital Heart Disease and Pediatric Cardiology, Deutsches Herzzentrum Munchen, Technische Universitat Munchen, 80636 Munchen, Germany. FAU - Uphoff, Isabel AU - Uphoff I AD - Department of Congenital Heart Disease and Pediatric Cardiology, Deutsches Herzzentrum Munchen, Technische Universitat Munchen, 80636 Munchen, Germany. FAU - Thussbas, Anna AU - Thussbas A AD - Institute of Preventive Pediatrics, Technische Universitat Munchen, 80809 Munchen, Germany. FAU - Willinger, Laura AU - Willinger L AUID- ORCID: 0000-0002-8577-4480 AD - Institute of Preventive Pediatrics, Technische Universitat Munchen, 80809 Munchen, Germany. FAU - Oberhoffer, Renate AU - Oberhoffer R AUID- ORCID: 0000-0002-3166-0488 AD - Institute of Preventive Pediatrics, Technische Universitat Munchen, 80809 Munchen, Germany. AD - Department of Congenital Heart Disease and Pediatric Cardiology, Deutsches Herzzentrum Munchen, Technische Universitat Munchen, 80636 Munchen, Germany. FAU - Ewert, Peter AU - Ewert P AUID- ORCID: 0000-0003-0253-1190 AD - Department of Congenital Heart Disease and Pediatric Cardiology, Deutsches Herzzentrum Munchen, Technische Universitat Munchen, 80636 Munchen, Germany. FAU - Muller, Jan AU - Muller J AUID- ORCID: 0000-0002-7530-2025 AD - Institute of Preventive Pediatrics, Technische Universitat Munchen, 80809 Munchen, Germany. LA - eng GR - no number/kinderherzen Fordergemeinschaft Deutsche Kinderherzzentren e.V./ GR - no number/Anneliese Pfannenberg-Stiftung/ PT - Journal Article DEP - 20260507 PL - Switzerland TA - J Cardiovasc Dev Dis JT - Journal of cardiovascular development and disease JID - 101651414 PMC - PMC13207293 OTO - NOTNLM OT - congenital heart disease OT - gamification OT - health promotion OT - mobile health OT - pediatric cardiology COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/05/26 17:41 MHDA- 2026/05/26 17:42 PMCR- 2026/05/07 CRDT- 2026/05/26 09:44 PHST- 2026/04/08 00:00 [received] PHST- 2026/05/04 00:00 [revised] PHST- 2026/05/05 00:00 [accepted] PHST- 2026/05/26 17:42 [medline] PHST- 2026/05/26 17:41 [pubmed] PHST- 2026/05/26 09:44 [entrez] PHST- 2026/05/07 00:00 [pmc-release] AID - jcdd13050199 [pii] AID - jcdd-13-00199 [pii] AID - 10.3390/jcdd13050199 [doi] PST - epublish SO - J Cardiovasc Dev Dis. 2026 May 7;13(5):199. doi: 10.3390/jcdd13050199. PMID- 42187309 OWN - NLM STAT- MEDLINE DCOM- 20260909 LR - 20260915 IS - 1539-2570 (Electronic) IS - 0271-6798 (Linking) VI - 46 IP - 9 DP - 2026 Oct 1 TI - Sports Participation Among Children and Adolescents Following Treatment With the Ponseti Method for Idiopathic Clubfoot: A Multicenter Survey Study. PG - e836-e841 LID - 10.1097/BPO.0000000000003323 [doi] AB - BACKGROUND: Idiopathic clubfoot is a complex congenital foot and ankle anomaly commonly treated with the Ponseti method. While gross motor function and activity level are similar in children with clubfoot treated with this method compared with children without clubfoot, data are lacking on sports participation following this treatment. This study aimed to describe the prevalence of sports participation among children with idiopathic clubfoot treated with the Ponseti method. METHODS: This was a multicenter retrospective cross-sectional study. Patients aged 5 to 17 years were included if they had been diagnosed with idiopathic clubfoot and treated with the Ponseti method during infancy. Parents of subjects were asked to complete a 1-time REDCap survey that included basic demographic questions, 2 validated activity scores (PROMIS Physical Activity Short Form and PACE+), and questions relating to sports participation. The comparison group consisted of the siblings of patients with clubfoot. RESULTS: One hundred fifty-one patients with clubfoot and 45 siblings without clubfoot were included from 4 institutions. In the clubfoot group, 72.2% of participants were male compared with 60% in the sibling group ( P =0.12). Median PROMIS-PA t-scores were 53.3 [interquartile range (IQR) 8.6] and 56.3 (IQR 13.2) in the clubfoot and sibling groups, respectively ( P =0.016). The median PACE+ scores were 4 (IQR 3.5) in the clubfoot group and 4.75 (IQR 2.75) ( P =0.261) in the sibling group. Sports participation was reported in 120 (79.5%) patients with clubfoot and 43 siblings (95.6%) ( P =0.006). Soccer, baseball, basketball, football, and swimming were the most commonly played sports in both groups. CONCLUSIONS: Children treated for idiopathic clubfoot with the Ponseti method remain active and participate in sports similar to their siblings. Further prospective studies examining sports participation and injury prevalence are needed to better understand long-term clinical and functional outcomes in patients treated with the Ponseti method for idiopathic clubfoot. STUDY DESIGN: Retrospective. LEVEL OF EVIDENCE: Level IV. CI - Copyright (c) 2026 Wolters Kluwer Health, LLC. All rights reserved. FAU - Weihe, James AU - Weihe J AD - Children's Mercy Kansas, Kansas City, MO. FAU - Bent, Melissa AU - Bent M AD - Children's Hospital Los Angeles, Los Angeles, CA. FAU - Kent, Lindsey AU - Kent L AD - Children's Hospital of Wisconsin, Milwaukee, Medical College of Wisconsin Affiliated Hospitals. FAU - Padilla, Abigail AU - Padilla A AD - Children's Hospital Los Angeles, Los Angeles, CA. FAU - Margherio, Shannon AU - Margherio S AD - Children's Mercy Kansas, Kansas City, MO. FAU - Carl, Rebecca AU - Carl R AD - Lurie Children's Hospital, Chicago, IL. FAU - Masrouha, Karim AU - Masrouha K AD - NYU Langone Orthopaedic Hospital, New York, NY. FAU - Lang, Pamela AU - Lang P AD - Shriners Children's Hospital, Twin Cities, Woodbury. FAU - Nemeth, Blaise AU - Nemeth B AD - Department of Orthopaedics and Rehabilitation, University of Wisconsin, Madison, WI. FAU - Stork, Natalie AU - Stork N AD - Department of Pediatrics, University of Minnesota, Gillette Children's Hospital, St. Paul, MN. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260526 PL - United States TA - J Pediatr Orthop JT - Journal of pediatric orthopedics JID - 8109053 SB - IM MH - Humans MH - *Clubfoot/surgery/therapy MH - Child MH - Retrospective Studies MH - Male MH - Cross-Sectional Studies MH - Adolescent MH - Female MH - Child, Preschool MH - *Sports/statistics & numerical data MH - Casts, Surgical MH - Treatment Outcome MH - Surveys and Questionnaires OTO - NOTNLM OT - Ponseti method OT - clubfoot OT - sports participation COIS- The authors declare no conflicts of interest. EDAT- 2026/05/26 17:41 MHDA- 2026/09/09 11:38 CRDT- 2026/05/26 09:13 PHST- 2025/10/16 00:00 [received] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/09/09 11:38 [medline] PHST- 2026/05/26 17:41 [pubmed] PHST- 2026/05/26 09:13 [entrez] AID - 01241398-990000000-01179 [pii] AID - 10.1097/BPO.0000000000003323 [doi] PST - ppublish SO - J Pediatr Orthop. 2026 Oct 1;46(9):e836-e841. doi: 10.1097/BPO.0000000000003323. Epub 2026 May 26. PMID- 42187247 OWN - NLM STAT- Publisher LR - 20260526 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 May 26 TI - Parents' perception of child's weight status, key to dietary habits' shaping: An epidemiological study. PG - 2601060261444653 LID - 10.1177/02601060261444653 [doi] AB - BackgroundDietary habits are one of the main factors in the prevention of chronic diseases, starting in childhood.AimThe present study investigated the possibility of an association between parents' perception of their children's body weight and their daily macronutrients and energy intakes.MethodsThe study sample consisted of 1073 parent-child pairs in Greece, with a mean age of the latter 11.18 +/- 0.818 years. The body mass index of children was calculated using weight and height, and classified using the cut-off criteria established by the World Obesity Federation. Dietary habits were evaluated with the semi-quantitative validated food frequency questionnaire, containing 21 items. Parental body weight perception of children determined by a researcher-made questionnaire. After anthropometric assessment, children were classified into two categories (normal vs. overweight/obesity).ResultsTwo hundred sixty-two children (24.4%) were living with an increased body weight. However, only 52.3% of the parents stated that they were aware of the fact, with the remaining percentage considering the weight as normal. Linear regression analysis showed a statistically significant correlation only between the parents' perception and the children's protein and fat intake (p = 0.021 and 0.015, respectively), an association that remained after the inclusion of confounding factors (p = 0.016 and p = 0.016, respectively).ConclusionParents' perceptions of their child's weight status appear to influence their child's dietary intake. Recognizing the existence of this relationship provides the impetus for reshaping children's diets and preventing childhood obesity. FAU - Kokkou, Stamatia AU - Kokkou S AUID- ORCID: 0000-0003-0717-3222 AD - Department of Public and Community Health, Laboratory of Hygiene and Epidemiology, School of Public Health, University of West Attica, Athens, Greece. RINGGOLD: 607347 FAU - Kanellopoulou, Aikaterini AU - Kanellopoulou A AUID- ORCID: 0000-0002-4766-6040 AD - Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, Athens, Greece. RINGGOLD: 68996 FAU - Antonogeorgos, George AU - Antonogeorgos G AUID- ORCID: 0000-0002-0515-7256 AD - Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, Athens, Greece. RINGGOLD: 68996 FAU - Rojas-Gil, Andrea Paola AU - Rojas-Gil AP AUID- ORCID: 0000-0002-9812-2131 AD - Department of Nursing, Faculty of Health Sciences, University of Peloponnese, Tripoli, Greece. FAU - Kornilaki, Ekaterina N AU - Kornilaki EN AUID- ORCID: 0000-0003-1723-7453 AD - Department of Preschool Education, School of Education, University of Crete, Rethimno, Greece. FAU - Lagiou, Areti AU - Lagiou A AUID- ORCID: 0000-0002-6687-358X AD - Department of Public and Community Health, Laboratory of Hygiene and Epidemiology, School of Public Health, University of West Attica, Athens, Greece. RINGGOLD: 607347 FAU - Panagiotakos, Demosthenes AU - Panagiotakos D AUID- ORCID: 0000-0001-8583-153X AD - Department of Nutrition and Dietetics, School of Health Sciences and Education, Harokopio University, Athens, Greece. RINGGOLD: 68996 FAU - Notara, Venetia AU - Notara V AUID- ORCID: 0000-0002-4080-8392 AD - Department of Public and Community Health, Laboratory of Hygiene and Epidemiology, School of Public Health, University of West Attica, Athens, Greece. RINGGOLD: 607347 LA - eng PT - Journal Article DEP - 20260526 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - Children OT - body weight OT - overweight/obesity OT - parents OT - weight perception EDAT- 2026/05/26 17:41 MHDA- 2026/05/26 17:41 CRDT- 2026/05/26 09:03 PHST- 2026/05/26 17:41 [medline] PHST- 2026/05/26 17:41 [pubmed] PHST- 2026/05/26 09:03 [entrez] AID - 10.1177/02601060261444653 [doi] PST - aheadofprint SO - Nutr Health. 2026 May 26:2601060261444653. doi: 10.1177/02601060261444653. PMID- 42187188 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260922 IS - 2314-6141 (Electronic) IS - 2314-6133 (Print) VI - 2026 IP - 1 DP - 2026 TI - Differential Effects of Individually Adapted Challenge-Oriented Heidelberg Ballschule Activities Versus Static Version on Motor Competence and Affective Engagement in 9-11-Year-Old Female Children. PG - e5244454 LID - 10.1155/bmri/5244454 [doi] LID - 5244454 AB - The widespread decline in motor competence and habitual physical activity (PA) among children underscores the need for innovative, intrinsically motivating pedagogical interventions. This quasiexperimental study examined the differential effects of two variants of the Heidelberg Ballschule program-one featuring individually adapted, challenge-oriented progression aligned with participants' optimal challenge points, and the other using static, nonprogressive tasks-on motor competence, affective engagement (enjoyment of PA), and weekly PA levels in 9-11-year-old female children in Kermanshah, Iran. Thirty girls aged 9-11 years were randomly assigned to either the challenge-oriented group (n = 15) or the static group (n = 15). Both groups engaged in Heidelberg Ballschule ball activities for 8 weeks (three sessions/week, 45-60 min/session). Motor competence was assessed pre- and postintervention using a standardized tool (e.g., Bruininks-Oseretsky Test of Motor Proficiency), affective engagement via a validated enjoyment questionnaire, and PA levels throughout the intervention period via self-report (Physical Activity Questionnaire for Children [PAQ-C]). Results indicated that the challenge-oriented group significantly outperformed the static group in overall motor competence (including gross and fine motor components), reported higher levels of affective engagement/enjoyment during PA, and exhibited greater weekly PA levels. These findings provide preliminary evidence that individually adapted, challenge-oriented Heidelberg Ballschule activities-grounded in the challenge point framework-effectively enhance motor competence, foster positive affective responses to PA, and promote increased PA participation in preadolescent girls. Such approaches hold promise for integration into school-based physical education programs to address motor and activity deficits. CI - Copyright (c) 2026 Neda Mohammad Veysi et al. BioMed Research International published by John Wiley & Sons Ltd. FAU - Veysi, Neda Mohammad AU - Veysi NM AD - Department of Motor Behaviour, Faculty of Sport Sciences, Razi University, Kermanshah, Iran, razi.ac.ir. FAU - Sabaghi, Ayoob AU - Sabaghi A AUID- ORCID: 0000-0002-5599-1986 AD - Department of Motor Behaviour, Faculty of Sport Sciences, Razi University, Kermanshah, Iran, razi.ac.ir. FAU - Ebrahimi, Behrooz AU - Ebrahimi B AUID- ORCID: 0000-0002-1250-3313 AD - Department of Motor Behaviour, Faculty of Sport Sciences, Razi University, Kermanshah, Iran, razi.ac.ir. LA - eng PT - Journal Article PL - United States TA - Biomed Res Int JT - BioMed research international JID - 101600173 SB - IM MH - Humans MH - Child MH - Female MH - *Motor Skills/physiology MH - *Exercise/physiology MH - *Affect/physiology MH - Iran PMC - PMC13202726 OTO - NOTNLM OT - Heidelberg Ballschule OT - affective engagement OT - challenge point framework OT - motor competence OT - physical activity OT - preadolescent girls COIS- The authors declare no conflicts of interest. EDAT- 2026/05/26 17:41 MHDA- 2026/05/26 23:33 PMCR- 2026/05/26 CRDT- 2026/05/26 08:33 PHST- 2025/12/13 00:00 [revised] PHST- 2024/11/14 00:00 [received] PHST- 2026/02/20 00:00 [accepted] PHST- 2026/05/26 23:33 [medline] PHST- 2026/05/26 17:41 [pubmed] PHST- 2026/05/26 08:33 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - BMRI5244454 [pii] AID - 10.1155/bmri/5244454 [doi] PST - ppublish SO - Biomed Res Int. 2026;2026(1):e5244454. doi: 10.1155/bmri/5244454. PMID- 42186028 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260813 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 25 IP - 1 DP - 2026 May 25 TI - Gut microbiota and western dietary patterns associated with behavioral problems in children and adolescents: a cross-sectional study. LID - 10.1186/s12937-026-01335-5 [doi] LID - 80 AB - BACKGROUND: Childhood and adolescence are crucial periods for brain development, during which multiple environmental factors, including gut microbiota and dietary habits, play important roles. However, the combined impact of those factors on neurodevelopment and mental disease risk remains largely unexplored. Here, we aimed to investigate the relationships between gut microbiota and diet and their role in classifying behavioral problems that may precede mental disorders in children and adolescents. METHODS: We performed a cross-sectional study, including data from 335 subjects, including 202 children (5-10 years) and 133 adolescents (11-17 years). Gut microbiota was analysed in stools by shotgun metagenomics. Dietary habits, lifestyle factors and emotional and behavioral difficulties were screened using validated questionnaires. Penalized Logistic Regression models were trained to classify individuals into Healthy and Behavioral Problem groups based on microbial diversity, differential abundance of bacterial species, dietary patterns, and food and nutrient intakes. Mediation analyses were applied to assess whether gut microbiota mediates the effect of diet on behavioral problems. RESULTS: A Western diet characterized by poor adherence to dietary recommendations was consistently associated with behavioral problems in all age groups. Individuals with behavioral problems exhibited distinct gut microbiota profiles characterized by lower levels of short-chain fatty acid-producing bacteria (particularly butyrate-producing species) and higher levels of potential pathogens (e.g., Campylobacter coli and Lautropia mirabilis), linked to poor dietary choices. Furthermore, we evidenced the mediation role of the gut microbiota in the association between dietary patterns and food groups and behavioral problems. In adolescents, L. mirabilis was identified as a mediator of the relationship between a Western diet and behavioral problems, while Anaerostipes rhamnosivorans mediated the relationship between fish consumption and behavioral problems. Gut microbiota data enhanced the classification accuracy of logistic regression models for identifying individuals with behavioral problems over models based solely on dietary data. CONCLUSION: Integrating dietary habits and gut microbiota data enables more accurate stratification of children and adolescents at risk for behavioral problems. Our findings may help to refine dietary interventions targeting the gut microbiota to improve mental health outcomes in these vulnerable populations. CI - (c) 2026. The Author(s). FAU - Larroya, A AU - Larroya A AD - Microbiome Innovation in Nutrition & Health, Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), Avda. Agustin Escardino, 7, Valencia, Paterna, 46980, Spain. FAU - Romera-Giner, S AU - Romera-Giner S AD - Microbiome Innovation in Nutrition & Health, Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), Avda. Agustin Escardino, 7, Valencia, Paterna, 46980, Spain. FAU - Tolosa-Enguis, V AU - Tolosa-Enguis V AD - Microbiome Innovation in Nutrition & Health, Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), Avda. Agustin Escardino, 7, Valencia, Paterna, 46980, Spain. FAU - Rodriguez-Ruano, S M AU - Rodriguez-Ruano SM AD - Microbiome Innovation in Nutrition & Health, Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), Avda. Agustin Escardino, 7, Valencia, Paterna, 46980, Spain. FAU - Andres-Garcia, S AU - Andres-Garcia S AD - Neurological Rehabilitation Center, Limbic, Valencia, 46015, Spain. FAU - Soro-Conde, I AU - Soro-Conde I AD - Neurological Rehabilitation Center, Limbic, Valencia, 46015, Spain. FAU - Codoner, P AU - Codoner P AD - Deparment of Pediatrics, Dr. Peset University Hospital, Avd. De Gaspar Aguilar, 80, Valencia, 46017, Spain. AD - Deparment of Pediatrics, Obstetrics and Gynecology, University of Valencia, Valencia, Spain. FAU - Sanz, Y AU - Sanz Y AD - Microbiome Innovation in Nutrition & Health, Institute of Agrochemistry and Food Technology, Spanish National Research Council (IATA-CSIC), Avda. Agustin Escardino, 7, Valencia, Paterna, 46980, Spain. yolsanz@iata.csic.es. LA - eng PT - Journal Article DEP - 20260525 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Child MH - Adolescent MH - Female MH - Male MH - *Gastrointestinal Microbiome/physiology MH - *Diet, Western/adverse effects MH - Child, Preschool MH - Feces/microbiology MH - Feeding Behavior MH - *Problem Behavior PMC - PMC13412121 OTO - NOTNLM OT - Behavior OT - Fibers OT - Gut-brain axis OT - Microbiota OT - Short-chain fatty acids OT - Western diet COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Medical Ethical Committee of Hospital Dr Peset in Valencia (approval number 131/20). The study was conducted following the code of ethics of the World Medical Association (Declaration of Helsinki) and ensuring data protection. All parents of children and adolescents provided written informed consent. In addition, participants over 12 years of age also provided their consent. Clinical trial number not applicable. STROBE recommendations were followed for data reporting. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/26 06:31 MHDA- 2026/07/30 12:42 PMCR- 2026/05/25 CRDT- 2026/05/26 00:06 PHST- 2025/05/09 00:00 [received] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/07/30 12:42 [medline] PHST- 2026/05/26 06:31 [pubmed] PHST- 2026/05/26 00:06 [entrez] PHST- 2026/05/25 00:00 [pmc-release] AID - 10.1186/s12937-026-01335-5 [pii] AID - 1335 [pii] AID - 10.1186/s12937-026-01335-5 [doi] PST - epublish SO - Nutr J. 2026 May 25;25(1):80. doi: 10.1186/s12937-026-01335-5. PMID- 42185601 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260828 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 May 25 TI - Sonographic evaluation of fetal abdominal subcutaneous tissue in pregnancies complicated by gestational and type 1 diabetes mellitus. LID - 10.1038/s41598-026-54402-6 [doi] LID - 23825 AB - To perform a comparative analysis of fetal abdominal fat mass (AFM) thickness in women diagnosed with gestational (GDM) and type 1 diabetes mellitus (T1DM), and to evaluate the efficacy of the ultrasonographic AFM measurement in the estimation of the fetal birth-weight (FBW) and prediction of fetal macrosomia. A total of 245 participants were recruited for this prospective observational cohort study, including women with diet-controlled GDM (GDMG1) (n = 50), insulin-controlled GDM (GDMG2) (n = 50), T1DM (n = 50) as well as non-diabetic control patients (n = 95). In each participant measurements of the AFM in conjunction with the standard fetal biometric parameters were performed within the 72 h period prior to delivery. Fetal macrosomia was defined as birth-weight >/= 4000 g irrespective of gestational age. After adjustment for confounding factors, median AFM and abdominal circumference (AC) measurements as well as the FBW were significantly higher among patients with T1DM as compared to other groups (p < 0.05). In each group both AFM and AC measurements showed strong positive correlations with the FBW (p < 0.001). Two new models comprising maternal (body mass index) and/or ultrasound-derived parameters (biparietal diameter, AC, AFM) for the FBW estimation were constructed. Both equations provided significantly lower mean absolute percent error among GDMG1 and T1DM women as compared to the Hadlock formula (p < 0.05). In addition novel equation for the prediction of fetal macrosomia, utilizing both AC and AFM measurements, yielded sensitivity of 84.8%, specificity 91.9%, positive predictive value 62.2% and negative predictive value of 97.5% within the total study population. In women with GDM/T1DM, the incorporation of the AFM measurement into equations for the FBW estimation provided better accuracy compared to standard formulas and increased the detection of fetal macrosomia. Further validation in large-scale multicenter studies is necessary prior to clinical implementation. CI - (c) 2026. The Author(s). FAU - Sliwka, Aleksandra AU - Sliwka A AD - 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Sq. 1/3, 02-015, Warsaw, Poland. FAU - Makowska, Katarzyna AU - Makowska K AD - 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Sq. 1/3, 02-015, Warsaw, Poland. FAU - Litwinska-Korcz, Ewelina AU - Litwinska-Korcz E AD - 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Sq. 1/3, 02-015, Warsaw, Poland. FAU - Litwinska, Magdalena AU - Litwinska M AD - 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Sq. 1/3, 02-015, Warsaw, Poland. FAU - Stanirowski, Pawel Jan AU - Stanirowski PJ AUID- ORCID: 0000-0001-7445-7546 AD - 1st Department of Obstetrics and Gynecology, Medical University of Warsaw, Starynkiewicza Sq. 1/3, 02-015, Warsaw, Poland. stanirowski@gmail.com. LA - eng PT - Journal Article PT - Observational Study DEP - 20260525 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Diabetes Mellitus, Type 1/diagnostic imaging/complications MH - Adult MH - *Fetal Macrosomia/diagnostic imaging MH - *Ultrasonography, Prenatal/methods MH - *Diabetes, Gestational/diagnostic imaging MH - Birth Weight MH - Prospective Studies MH - *Subcutaneous Fat, Abdominal/diagnostic imaging MH - *Fetus/diagnostic imaging MH - Infant, Newborn PMC - PMC13434002 OTO - NOTNLM OT - Fetal abdominal subcutaneous tissue OT - Fetal birth-weight OT - Fetal macrosomia OT - Fetal soft-tissue OT - Gestational diabetes mellitus OT - Type 1 diabetes mellitus OT - Ultrasound COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki Ethical Principles and Good Clinical Practices. The Local Ethics Committee of the Medical University of Warsaw approved the study, and all participants signed their written informed consent (ref no. KB/36/2022). Competing interests: The authors declare no competing interests. EDAT- 2026/05/26 00:29 MHDA- 2026/08/04 00:35 PMCR- 2026/05/25 CRDT- 2026/05/25 23:29 PHST- 2025/10/26 00:00 [received] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/08/04 00:35 [medline] PHST- 2026/05/26 00:29 [pubmed] PHST- 2026/05/25 23:29 [entrez] PHST- 2026/05/25 00:00 [pmc-release] AID - 10.1038/s41598-026-54402-6 [pii] AID - 54402 [pii] AID - 10.1038/s41598-026-54402-6 [doi] PST - epublish SO - Sci Rep. 2026 May 25;16(1):23825. doi: 10.1038/s41598-026-54402-6. PMID- 42184479 OWN - NLM STAT- MEDLINE DCOM- 20260610 LR - 20260610 IS - 1095-6867 (Electronic) IS - 0018-506X (Linking) VI - 182 DP - 2026 Jun TI - Demasculinized digit ratios in a sample of boys with childhood autism. PG - 105950 LID - S0018-506X(26)00075-9 [pii] LID - 10.1016/j.yhbeh.2026.105950 [doi] AB - Some theories have proposed that children with autism spectrum disorder (ASD) may be exposed to increased levels of androgens during prenatal development, resulting in greater androgenization of testosterone-dependent traits including both peripheral (bodily) and central (brain-related) traits. Empirical support for this hypothesis is scant and inconsistent. In the present work, we studied an ostensible anatomical marker of testosterone exposure (sexually differentiated finger lengths) which develops during the first trimester or early second trimester of gestation. Participants were 25 boys with classic autism, recruited from the clinical practice of a local physician specializing in childhood autism, who met the standardized DSM (Diagnostic and Statistical Manual) criteria for ASD, and 57 normally-developing age- and sex-matched male and female controls (32 males, 25 females); N = 82; M(age) = 7.30 yrs., SD = 4.18. Finger length was measured to the nearest 0.5 mm from digital images of the ventral surface of the hands using a validated measurement protocol. Consistent with past reports from adult samples, several of the finger length ratios were confirmed to display sex differences among control children, but the group of boys with ASD showed a female-like finger growth pattern, not the hypermasculine pattern predicted, and were found to differ statistically from the male controls. Boys with ASD thus showed a demasculinized pattern of finger differentiation. Our data do not support theories which suggest that greater fetal testosterone exposure occurs in boys with autism. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Hampson, Elizabeth AU - Hampson E AD - Department of Psychology, University of Western Ontario, London, ON, Canada; Department of Psychiatry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada. Electronic address: ehampson@uwo.ca. FAU - Waxman, Samantha E AU - Waxman SE AD - Department of Psychology, University of Western Ontario, London, ON, Canada. FAU - Nicolson, Robert AU - Nicolson R AD - Department of Psychiatry, Schulich School of Medicine and Dentistry, University of Western Ontario, London, ON, Canada. LA - eng PT - Journal Article DEP - 20260525 PL - United States TA - Horm Behav JT - Hormones and behavior JID - 0217764 RN - 3XMK78S47O (Testosterone) SB - IM MH - Humans MH - Male MH - Female MH - Child MH - *Digit Ratios MH - Testosterone MH - *Fingers/anatomy & histology MH - *Autistic Disorder/pathology MH - *Autism Spectrum Disorder/pathology MH - Sex Characteristics MH - Child, Preschool OTO - NOTNLM OT - 2D:4D OT - ASD OT - Androgen OT - Autism spectrum disorder OT - Estradiol OT - Estrogens OT - Finger length ratio OT - Prenatal OT - Testosterone COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: R. Nicolson reports a relationship with Brain Canada Foundation that includes: funding grants. R. Nicolson reports a relationship with Hoffmann-La Roche Limited that includes: funding grants. R. Nicolson reports a relationship with Otsuka Pharmaceutical Co., Ltd. that includes: funding grants. R. Nicolson reports a relationship with MapLight Therapeutics Inc. that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/25 18:30 MHDA- 2026/06/11 05:41 CRDT- 2026/05/25 17:59 PHST- 2025/11/10 00:00 [received] PHST- 2026/05/19 00:00 [revised] PHST- 2026/05/20 00:00 [accepted] PHST- 2026/06/11 05:41 [medline] PHST- 2026/05/25 18:30 [pubmed] PHST- 2026/05/25 17:59 [entrez] AID - S0018-506X(26)00075-9 [pii] AID - 10.1016/j.yhbeh.2026.105950 [doi] PST - ppublish SO - Horm Behav. 2026 Jun;182:105950. doi: 10.1016/j.yhbeh.2026.105950. Epub 2026 May 25. PMID- 42184215 OWN - NLM STAT- Publisher LR - 20260525 IS - 2156-535X (Electronic) IS - 2156-5333 (Linking) DP - 2026 May 25 TI - Influence of Personalized Advice on Cardiovascular Management in Childhood Cancer Survivors. PG - 21565333261454210 LID - 10.1177/21565333261454210 [doi] AB - PURPOSE: This study aimed to evaluate the cardiovascular medical management of young adults who had viewed the massive open online course (MOOC) "Childhood Cancer, Living Well, After" four years earlier during the feasibility study (START-MOOC1), compared with those who had not. METHODS: A retrospective, descriptive, French multicenter study was conducted involving 322 childhood cancer survivors (CCS) (range, 20-36 years) eligible to view the cardiovascular health module of the MOOC. Participants were divided into two groups those who had viewed the MOOC (MOOC+) four years earlier and those who had not (MOOC-). We collected data on medical follow-up, cardiovascular care, and lifestyle habits using a short questionnaire. We analyzed it using descriptive statistics and comparative tests. RESULTS: Of the 322 eligible CCS, 95 completed the questionnaire (34 MOOC+ and 61 MOOC-). The participation rate was significantly higher in the MOOC+ group (55.7% vs. 23.4%, p < 0.0001). We found no significant difference between the groups regarding general medical care and cardiologist follow-up. However, 20% of MOOC+ participants began cardiological follow-up after the MOOC, 15% increased their physical activity, and 6% improved their diet. In addition, 25% of MOOC+ participants began complementary therapies. CONCLUSION: The MOOC "Childhood Cancer, Living Well, After" did not result in any significant difference in cardiovascular follow-up behaviors compared with patients who did not view the MOOC. However, the MOOC+ group promoted positive lifestyle changes. Further research with a larger cohort is necessary to assess the full impact of the MOOC on the long-term medical follow-up. FAU - Fremont, Lea AU - Fremont L AD - Department of Pediatric Hematology and Oncology, University-Hospital of Saint-Etienne, Saint-Etienne, France. FAU - Casagranda, Leonie AU - Casagranda L AUID- ORCID: 0000-0001-9297-6278 AD - Department of Pediatric Hematology and Oncology, University-Hospital of Saint-Etienne, Saint-Etienne, France. AD - UMR-S1153, Inserm, Paris Descartes University, Paris, France. FAU - Sudour-Bonnange, Helene AU - Sudour-Bonnange H AD - Department of Pediatric Oncology, AYA Unit, Oscar Lambret Institute, Lille, France. FAU - Massoubre, Catherine AU - Massoubre C AD - Department of Psychiatry, University-Hospital of Saint-Etienne, Saint-Etienne, France. FAU - Dalle, Jean-Hugues AU - Dalle JH AD - Department of Immunology and Hematology, Robert Debre Hospital, GHU APHP-Nord Universite Paris Cite, Paris, France. FAU - Teinturier, Cecile AU - Teinturier C AD - Department of Pediatric Endocrinology and Diabetology, Bicetre Hospital, Paris Sud University, Kremlin Bicetre, France. AD - Inserm U 1018, CESP, Cancer and Radiation Team, University of Paris-Saclay, Paris-Sud University, Villejuif, France. FAU - Guillot, Pascale AU - Guillot P AD - Department of Rheumatology, University Hospital Nantes, Nantes, France. FAU - Lanlo, Virginie AU - Lanlo V AD - Consultant Communication and Pedagogical Designer Specialized in MOOC, Pantin, France. FAU - Dal Molin, Bernard AU - Dal Molin B AD - Advita Productions, Grenoble, France. FAU - Dal Molin, Michele AU - Dal Molin M AD - Advita Productions, Grenoble, France. FAU - Garcin, Arnauld AU - Garcin A AD - Department of Research, University Hospital, Saint-Etienne, France. AD - Host Research Team EA4607 SNA-EPIS, Jean Monnet University of Saint-Etienne, PRES Lyon, Saint-Etienne, France. FAU - Fresneau, Brice AU - Fresneau B AD - Inserm U 1018, CESP, Cancer and Radiation Team, University of Paris-Saclay, Paris-Sud University, Villejuif, France. AD - Department of Pediatric Oncology, Gustave Roussy, University of Paris-Saclay, Villejuif, France. FAU - Poulalhon, Claire AU - Poulalhon C AD - UMR-S1153, Inserm, Paris Descartes University, Paris, France. FAU - Demoor-Goldschmidt, Charlotte AU - Demoor-Goldschmidt C AD - Inserm U 1018, CESP, Cancer and Radiation Team, University of Paris-Saclay, Paris-Sud University, Villejuif, France. AD - Department of Pediatric Hematology and Oncology, University-Hospital of Angers, Angers, France. FAU - Berger, Claire AU - Berger C AD - UMR-S1153, Inserm, Paris Descartes University, Paris, France. AD - Department of Public Health and Medical Informatics, University-Hospital, Saint-Etienne, France. LA - eng PT - Journal Article DEP - 20260525 PL - United States TA - J Adolesc Young Adult Oncol JT - Journal of adolescent and young adult oncology JID - 101543508 SB - IM OTO - NOTNLM OT - MOOC OT - cardiovascular follow-up OT - childhood cancer survivors OT - health literacy OT - long-term care OT - therapeutic education EDAT- 2026/05/25 18:30 MHDA- 2026/05/25 18:30 CRDT- 2026/05/25 13:03 PHST- 2026/05/25 18:30 [medline] PHST- 2026/05/25 18:30 [pubmed] PHST- 2026/05/25 13:03 [entrez] AID - 10.1177/21565333261454210 [doi] PST - aheadofprint SO - J Adolesc Young Adult Oncol. 2026 May 25:21565333261454210. doi: 10.1177/21565333261454210. PMID- 42184096 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260825 IS - 1600-0838 (Electronic) IS - 0905-7188 (Linking) VI - 36 IP - 6 DP - 2026 Jun TI - Dose-Response Effects of a 4-Month FIT FIRST 10 School-Based Multisport Programme on Physical Fitness and Psychosocial Well-Being in Children Aged 7-11: A Three-Arm Cluster-Randomized Controlled Trial. PG - e70311 LID - 10.1111/sms.70311 [doi] AB - Low physical activity (PA) and fitness in childhood are linked to adverse health outcomes, yet many Danish children do not meet national guidelines. The FIT FIRST 10 (FF10) multisport PE programme was developed to increase PA in primary schools. To evaluate dose-response effects of a 4-month FF10 intervention on physical fitness and psychosocial well-being. Three-arm, cluster-randomized trial (1:1:1). 1357 pupils (7-11 years) from 68 classes in 27 schools were allocated to control (CON, n = 529), 1.5 FF10 sessions/week (1.5INT, n = 495), or 3 FF10 sessions/week (3INT, n = 333); 1175 provided consent. The primary outcome was cardiorespiratory fitness via the Yo-Yo Intermittent Recovery Level 1 Children's test (YYIR1C). Secondary outcomes included cardiometabolic health, muscular fitness, and psychosocial well-being. No between-group effects were observed for the primary outcome (1.5INT vs. CON: 17 m [-19, 52]; 3INT vs. CON: -8 m [-47, 31]). Among secondary outcomes, 1.5INT showed small favorable effects on body composition (body fat percentage -0.4%; fat mass -0.2 kg; fat mass index -0.1 kg/m(2); BMI -0.1 kg/m(2)) and handgrip strength (+0.4 kg) (all p < 0.05). No intervention effects were observed for cardiovascular or psychosocial domains. Small differences favoring CON over 3INT emerged in standing long jump (-5 cm), postural balance (-0.5 s) and perceived flexibility (-0.3 AU) (all p < 0.05). In conclusion, a moderate, feasible dose of approximately 1.5 FF10 sessions per week appeared more effective than a higher-frequency implementation, highlighting the importance of feasibility and implementation fidelity in real-world school settings. ClinicalTrials.gov (NCT06180772). CI - (c) 2026 The Author(s). Scandinavian Journal of Medicine & Science In Sports published by John Wiley & Sons Ltd. FAU - Eckert, Caroline AU - Eckert C AD - Department of Sports Sciences and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. FAU - Thogersen-Ntoumani, Cecilie AU - Thogersen-Ntoumani C AD - Department of Sports Sciences and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. AD - Danish Centre for Motivation and Behaviour Science (DRIVEN), University of Southern Denmark, Odense, Denmark. AD - School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK. FAU - Larsen, Malte Nejst AU - Larsen MN AD - Department of Sports Sciences and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. FAU - Koch, Sofie AU - Koch S AD - Department of Sports Sciences and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. FAU - Christiansen, Lars Breum AU - Christiansen LB AD - Department of Sports Sciences and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. FAU - Meiner, Christina Birch AU - Meiner CB AUID- ORCID: 0000-0001-5780-565X AD - Department of Sports Sciences and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. FAU - Cimenti, Chiara AU - Cimenti C AUID- ORCID: 0009-0002-7302-4911 AD - Department of Sports Sciences and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. AD - Danish Centre for Motivation and Behaviour Science (DRIVEN), University of Southern Denmark, Odense, Denmark. FAU - Tarantino, Giampiero AU - Tarantino G AD - Department of Sports Sciences and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. AD - Danish Centre for Motivation and Behaviour Science (DRIVEN), University of Southern Denmark, Odense, Denmark. FAU - Ntoumanis, Nikos AU - Ntoumanis N AD - Department of Sports Sciences and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. AD - Danish Centre for Motivation and Behaviour Science (DRIVEN), University of Southern Denmark, Odense, Denmark. AD - School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK. AD - Danish Institute for Advanced Study (DIAS), University of Southern Denmark, Odense, Denmark. FAU - Krustrup, Peter AU - Krustrup P AUID- ORCID: 0000-0002-1461-9838 AD - Department of Sports Sciences and Clinical Biomechanics, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. AD - Danish Centre for Motivation and Behaviour Science (DRIVEN), University of Southern Denmark, Odense, Denmark. AD - Danish Institute for Advanced Study (DIAS), University of Southern Denmark, Odense, Denmark. AD - Sport and Health Sciences, University of Exeter, Exeter, UK. LA - eng SI - ClinicalTrials.gov/NCT06180772 GR - NNF22SH0077612/Novo Nordisk Fonden/ PT - Journal Article PT - Randomized Controlled Trial PL - Denmark TA - Scand J Med Sci Sports JT - Scandinavian journal of medicine & science in sports JID - 9111504 SB - IM MH - Humans MH - Child MH - *Cardiorespiratory Fitness MH - Male MH - Female MH - Schools MH - Denmark MH - Psychological Well-Being MH - *Physical Fitness MH - *Physical Education and Training/methods MH - Muscle Strength MH - *Exercise OTO - NOTNLM OT - cluster-randomized controlled trial OT - dose-response OT - health OT - multisport programme OT - physical fitness OT - primary school children OT - school-based physical activity OT - well-being EDAT- 2026/05/25 12:35 MHDA- 2026/05/25 12:36 CRDT- 2026/05/25 11:23 PHST- 2026/05/15 00:00 [revised] PHST- 2025/11/21 00:00 [received] PHST- 2026/05/17 00:00 [accepted] PHST- 2026/05/25 12:36 [medline] PHST- 2026/05/25 12:35 [pubmed] PHST- 2026/05/25 11:23 [entrez] AID - 10.1111/sms.70311 [doi] PST - ppublish SO - Scand J Med Sci Sports. 2026 Jun;36(6):e70311. doi: 10.1111/sms.70311. PMID- 42183855 OWN - NLM STAT- MEDLINE DCOM- 20260712 LR - 20261010 IS - 1432-1998 (Electronic) IS - 0301-0449 (Linking) VI - 56 IP - 7 DP - 2026 Jun TI - Increased parotid microvascularity without stiffness differences in children with celiac disease. PG - 1536-1546 LID - 10.1007/s00247-026-06641-y [doi] AB - BACKGROUND: Celiac disease is a systemic autoimmune disorder that can affect salivary glands, yet subclinical involvement in children is under-investigated. Conventional ultrasound often lacks sensitivity for detecting early inflammatory or subtle microvascular changes in asymptomatic patients. OBJECTIVE: We aimed to evaluate subclinical parotid gland involvement in children with celiac disease using microvascular imaging and shear wave elastography (SWE), hypothesizing that these tools could detect early parenchymal and microcirculatory alterations. MATERIALS AND METHODS: This prospective, cross-sectional case-control study included 78 children with biopsy-confirmed celiac disease and 72 age- and body mass index-matched healthy controls. Bilateral parotid microvascularity index (MVI, %) and tissue stiffness (SWE, kPa) were assessed using high-resolution ultrasonography by an experienced radiologist who was blinded to the group allocation and clinical data. Between-group comparisons were performed using two-sided Mann-Whitney U tests. Within the celiac disease group, imaging metrics were explored according to gluten-free diet duration, serum tissue transglutaminase IgA (tTG-IgA) levels, and modified Marsh grade. RESULTS: The MVI was higher in the celiac disease group for both the left (median [interquartile range], 5.29 [3.12-10.80] vs 2.00 [1.03-4.78]; P<0.001) and right (4.55 [2.42-10.82] vs 3.25 [0.90-5.48]; P=0.001) parotid glands. However, SWE did not differ significantly between groups (left P=0.21; right P=0.09). Within the celiac disease group, imaging metrics were not significantly associated with tTG-IgA levels or Marsh subtypes (all P>0.05). CONCLUSION: Pediatric celiac disease is associated with increased parotid microvascularity without detectable stiffness differences, suggesting subclinical microvascular alterations. These exploratory findings warrant longitudinal validation to clarify temporal dynamics and clinical relevance. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Ergen, Yasin Maruf AU - Ergen YM AD - Department of Pediatric Gastroenterology, Gulhane Training and Research Hospital, General Dr. Tevfik Saglam Cad. No: 11, Etlik, Kecioren, Ankara, 06018, Turkey. yasinmaruf@gmail.com. FAU - Teke, Selcuk AU - Teke S AD - Department of Pediatric Gastroenterology, Gulhane Training and Research Hospital, General Dr. Tevfik Saglam Cad. No: 11, Etlik, Kecioren, Ankara, 06018, Turkey. FAU - Cavis, Tugba AU - Cavis T AD - Gulhane Training and Research Hospital, Department of Radiology, Saglik Bilimleri Universitesi, Ankara, Turkey. FAU - Basaran, Edibe Gozde AU - Basaran EG AD - Department of Pediatric Gastroenterology, Gulhane Training and Research Hospital, General Dr. Tevfik Saglam Cad. No: 11, Etlik, Kecioren, Ankara, 06018, Turkey. FAU - Akcay, Birce Izgi AU - Akcay BI AD - Department of Pediatric Gastroenterology, Gulhane Training and Research Hospital, General Dr. Tevfik Saglam Cad. No: 11, Etlik, Kecioren, Ankara, 06018, Turkey. FAU - Balamtekin, Necati AU - Balamtekin N AD - Department of Pediatric Gastroenterology, Gulhane Training and Research Hospital, General Dr. Tevfik Saglam Cad. No: 11, Etlik, Kecioren, Ankara, 06018, Turkey. LA - eng PT - Journal Article DEP - 20260525 PL - Germany TA - Pediatr Radiol JT - Pediatric radiology JID - 0365332 SB - IM MH - Humans MH - *Celiac Disease/diagnostic imaging/pathology MH - Female MH - Male MH - *Elasticity Imaging Techniques/methods MH - *Parotid Gland/diagnostic imaging/blood supply MH - Cross-Sectional Studies MH - Prospective Studies MH - Case-Control Studies MH - Child MH - *Microvessels/diagnostic imaging MH - Child, Preschool MH - Adolescent MH - Microcirculation OTO - NOTNLM OT - Celiac disease OT - Children OT - Microvascular imaging OT - Parotid gland OT - Shear wave elastography COIS- Declarations. Consent to participate: Written informed consent was obtained from parents or legal guardians prior to participation, and assent was obtained from children whenever applicable. Conflicts of interest: None EDAT- 2026/05/25 12:35 MHDA- 2026/07/13 00:32 CRDT- 2026/05/25 11:02 PHST- 2025/12/30 00:00 [received] PHST- 2026/05/03 00:00 [accepted] PHST- 2026/04/07 00:00 [revised] PHST- 2026/07/13 00:32 [medline] PHST- 2026/05/25 12:35 [pubmed] PHST- 2026/05/25 11:02 [entrez] AID - 10.1007/s00247-026-06641-y [pii] AID - 10.1007/s00247-026-06641-y [doi] PST - ppublish SO - Pediatr Radiol. 2026 Jun;56(7):1536-1546. doi: 10.1007/s00247-026-06641-y. Epub 2026 May 25. PMID- 42183740 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261020 IS - 1879-3479 (Electronic) IS - 0020-7292 (Print) IS - 0020-7292 (Linking) VI - 175 IP - 2 DP - 2026 Nov TI - An external validation study of a practical scoring system for identifying patients at risk of pelvic floor dysfunction following childbirth. PG - 807-816 LID - 10.1002/ijgo.71099 [doi] AB - OBJECTIVE: To prospectively evaluate the perineal card, a risk-based scoring system, for identifying women at increased risk of postpartum urinary incontinence (UI). METHODS: This prospective observational study included women without previous vaginal delivery who underwent vaginal birth at a tertiary referral center between June 2023 and October 2024. The perineal card was completed at hospital discharge to assess obstetric and perineal risk factors and classify patients into low-, intermediate-, and high-risk groups. Postpartum pelvic floor outcomes were assessed at follow-up using a standardized screening tool with validated questionnaires. Logistic regression identified factors independently associated with UI, and discriminative performance was evaluated by receiver operating characteristic analysis. RESULTS: Of 296 enrolled women, 265 were included in the final analysis. At follow-up, 18.3% reported UI. Women with UI had higher median perineal card scores than asymptomatic women. UI during pregnancy, pre-pregnancy body mass index (BMI), labor induction, and postpartum urinary retention lasting more than 24 h were independently associated with postpartum UI. The perineal card showed moderate discriminative ability, with an area under the curve of 0.65. CONCLUSION: Use of the perineal card at discharge may help identify women at increased risk of postpartum UI and support timely referral for pelvic floor rehabilitation. CI - (c) 2026 The Author(s). International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics. FAU - Arcieri, Martina AU - Arcieri M AUID- ORCID: 0000-0002-8257-0618 AD - Clinic of Obstetrics and Gynecology, "Santa Maria Della Misericordia" University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy. FAU - Segatti, Michela AU - Segatti M AD - Department of Medicine (DMED), University of Udine, Udine, Italy. FAU - Bordin, Filippo AU - Bordin F AD - Clinic of Obstetrics and Gynecology, "Santa Maria Della Misericordia" University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy. AD - Department of Medicine (DMED), University of Udine, Udine, Italy. FAU - Armenise, Doriana AU - Armenise D AUID- ORCID: 0009-0007-9531-8159 AD - Clinic of Obstetrics and Gynecology, "Santa Maria Della Misericordia" University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy. AD - Department of Medicine (DMED), University of Udine, Udine, Italy. FAU - De Martino, Maria AU - De Martino M AD - Department of Medicine (DMED), Institute of Statistics, University of Udine, Udine, Italy. FAU - Isola, Miriam AU - Isola M AD - Department of Medicine (DMED), Institute of Statistics, University of Udine, Udine, Italy. FAU - Mattiussi, Chiara AU - Mattiussi C AD - Clinic of Obstetrics and Gynecology, "Santa Maria Della Misericordia" University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy. FAU - Barbui, Elisa AU - Barbui E AD - Clinic of Obstetrics and Gynecology, "Santa Maria Della Misericordia" University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy. FAU - Filippin, Sara AU - Filippin S AD - Clinic of Obstetrics and Gynecology, "Santa Maria Della Misericordia" University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy. AD - Department of Medicine (DMED), University of Udine, Udine, Italy. FAU - Tius, Veronica AU - Tius V AD - Clinic of Obstetrics and Gynecology, "Santa Maria Della Misericordia" University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy. AD - Department of Medicine (DMED), University of Udine, Udine, Italy. FAU - Delneri, Cristina AU - Delneri C AD - Rehabilitation Medicine Unit Trieste, "San Polo" Hospital - Monfalcone, Azienda Sanitaria Universitaria Giuliano Isontina, Monfalcone, Italy. FAU - Dialti, Valeria AU - Dialti V AD - Physical Medicine and Rehabilitation - Severe Brain Injury Unit / General Rehabilitation, Institute of Physical Medicine and Rehabilitation "Gervasutta," Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy. FAU - Restaino, Stefano AU - Restaino S AUID- ORCID: 0000-0002-7848-0329 AD - Clinic of Obstetrics and Gynecology, "Santa Maria Della Misericordia" University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy. AD - PhD School in Biomedical Sciences, Gender Medicine, Child and Women Health, University of Sassari, Sassari, Italy. FAU - Driul, Lorenza AU - Driul L AD - Clinic of Obstetrics and Gynecology, "Santa Maria Della Misericordia" University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy. AD - Department of Medicine (DMED), University of Udine, Udine, Italy. FAU - Vizzielli, Giuseppe AU - Vizzielli G AD - Clinic of Obstetrics and Gynecology, "Santa Maria Della Misericordia" University Hospital, Azienda Sanitaria Universitaria Friuli Centrale, Udine, Italy. AD - Department of Medicine (DMED), University of Udine, Udine, Italy. LA - eng PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20260525 PL - United States TA - Int J Gynaecol Obstet JT - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JID - 0210174 SB - IM MH - Humans MH - Female MH - Adult MH - Prospective Studies MH - Pregnancy MH - *Urinary Incontinence/etiology/epidemiology/diagnosis MH - Risk Factors MH - *Pelvic Floor Disorders/etiology/diagnosis MH - *Delivery, Obstetric/adverse effects MH - Surveys and Questionnaires MH - Postpartum Period MH - Risk Assessment/methods MH - ROC Curve MH - Pelvic Floor/physiopathology MH - *Puerperal Disorders/diagnosis/etiology PMC - PMC13674847 OTO - NOTNLM OT - pelvic floor dysfunction OT - perineal card OT - postpartum rehabilitation OT - urinary incontinence OT - vaginal delivery COIS- The authors declare no conflicts of interest. EDAT- 2026/05/25 12:35 MHDA- 2026/10/16 19:04 PMCR- 2026/10/16 CRDT- 2026/05/25 09:32 PHST- 2026/05/03 00:00 [revised] PHST- 2026/03/21 00:00 [received] PHST- 2026/05/09 00:00 [accepted] PHST- 2026/10/16 19:04 [medline] PHST- 2026/05/25 12:35 [pubmed] PHST- 2026/05/25 09:32 [entrez] PHST- 2026/10/16 00:00 [pmc-release] AID - IJGO71099 [pii] AID - 10.1002/ijgo.71099 [doi] PST - ppublish SO - Int J Gynaecol Obstet. 2026 Nov;175(2):807-816. doi: 10.1002/ijgo.71099. Epub 2026 May 25. PMID- 42183553 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260525 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - The role of physical exercise in promoting bystander intervention in school bullying: evidence from cross-sectional and longitudinal studies. PG - 1718104 LID - 10.3389/fpsyg.2026.1718104 [doi] LID - 1718104 AB - BACKGROUND: School bullying is a pervasive global concern that profoundly affects teenagers' development and mental health. This study examines the influence of physical exercise on bystander intervention in bullying, analyzing the psychological mechanisms that underpin this relationship through the frameworks of embodied cognition and mind-body interaction theories. OBJECTIVE: The study aims to determine if physical exercise facilitates bystander intervention in school bullying by improving physical self-efficacy and a sense of justice. METHODS: In 2024, a cross-sectional survey was administered with 954 middle school students (566 males, 388 females; mean age 13.85 years) in Jiangxi, China. Participants completed validated instruments measuring physical exercise, self-efficacy, sense of justice, and bystander intervention behavior. Data were analyzed utilizing SPSS and AMOS structural equation modeling (SEM) to evaluate the correlation between physical exercise and bystander conduct, along with the mediating effects of physical self-efficacy and sense of justice. A duration of 8 weeks involving martial arts with 51 male pupils was employed to investigate potential causal links. A Repeated-Measures ANOVA was performed to assess the impact of the intervention. RESULTS: Structural equation modeling indicated that physical exercise strongly predicts bystander intervention behavior (beta = 0.124, p < 0.01), with physical self-efficacy (beta = 0. 118, p < 0.01) and sense of justice (beta = 0.095, p < 0.01) acting as mediators. The intervention outcomes indicated enhancements in physical self-efficacy and sense of justice, resulting in a rise in bystander intervention. CONCLUSION: These findings indicate that physical exercise can significantly facilitate the transition of bystanders from passive viewers to proactive helpers, providing essential insights for the mitigation and prevention of school bullying. CI - Copyright (c) 2026 Zhou, Chen and Xiao. FAU - Zhou, Xinwei AU - Zhou X AD - School of Physical Education and Health, Jiangxi Science and Technology Normal University, Nanchang, Jiangxi, China. FAU - Chen, Yanlan AU - Chen Y AD - School of Physical Education, Guangdong University of Education, Guangzhou, Guangdong, China. FAU - Xiao, Hui AU - Xiao H AD - School of Physical Education and Health, Jiangxi Science and Technology Normal University, Nanchang, Jiangxi, China. LA - eng PT - Journal Article DEP - 20260508 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13193937 OTO - NOTNLM OT - bystander intervention behavior OT - embodied cognition OT - physical exercise OT - physical self-efficacy OT - sense of justice COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/25 12:35 MHDA- 2026/05/25 12:36 PMCR- 2026/05/08 CRDT- 2026/05/25 08:19 PHST- 2025/10/03 00:00 [received] PHST- 2026/04/20 00:00 [revised] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/05/25 12:36 [medline] PHST- 2026/05/25 12:35 [pubmed] PHST- 2026/05/25 08:19 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1718104 [doi] PST - epublish SO - Front Psychol. 2026 May 8;17:1718104. doi: 10.3389/fpsyg.2026.1718104. eCollection 2026. PMID- 42183298 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Serum and cerebrospinal fluid neuroinflammatory biomarkers and trimethylamine N-oxide: associations with white matter lesion severity. PG - 1799968 LID - 10.3389/fimmu.2026.1799968 [doi] LID - 1799968 AB - INTRODUCTION: This study aimed to investigate the association between a multi-panel biomarker profile across the blood-brain barrier and the severity of white matter lesions (WML) in 42 patients [mean age: 60.3 +/- 12.1 years; 45.2% male], suggesting a potential inflammatory endotype rather than defining a distinct phenotype due to the cross-sectional design and limited sample size. We assessed the gut-brain axis role in WML pathogenesis through analysis of paired serum and cerebrospinal fluid samples. METHODS: In this cross-sectional clinical study, 42 patients (aged 16-78 years; inclusion of younger subjects was based on radiological confirmation of WML unrelated to acute cerebrovascular events) with radiologically confirmed WML were stratified into four severity groups based on combined Fazekas global score (range 0-3, incorporating both periventricular and deep white matter hyperintensities). Levels of six biomarkers-interleukin-1beta (IL-1beta), matrix metalloproteinase-2 (MMP-2), tumor necrosis factor-alpha (TNF-alpha), trimethylamine N-oxide (TMAO), S100 calcium-binding protein beta (S100beta), and immunoglobulin G (IgG)-were simultaneously quantified in paired serum and cerebrospinal fluid (CSF) samples using ELISA. Statistical analyses included: (1) group comparisons using one-way ANOVA with LSD post-hoc tests; (2) Spearman correlation analyses; (3) multivariable ordinal logistic regression adjusting for age, sex, hypertension, diabetes, and BMI to control confounding; (4) False Discovery Rate (FDR) correction for multiple comparisons (Benjamini-Hochberg method). Post-hoc power analysis and effect sizes (eta(2), Cohen's d) were reported. RESULTS: Severity-dependent increases in IL-1beta, TNF-alpha, and the gut-derived metabolite TMAO were observed in both serum and CSF. After adjustment for confounders, CSF TNF-alpha (adjusted OR = 1.95, 95% CI: 1.42-2.68, P<0.001) and serum MMP-2 (adjusted OR = 1.72, 95% CI: 1.28-2.31, P<0.001) demonstrated the strongest correlations with WML severity among all biomarkers, establishing them as primary candidate biomarkers. An inverse concentration pattern (elevated serum/decreased CSF) was observed for MMP-2, suggesting stage-specific roles in blood-brain barrier dynamics. CSF S100beta levels increased with severity (r=0.487, P<0.001), consistent with parenchymal injury. Regarding IgG, while univariate analysis showed marginal significance in CSF (P = 0.045), FDR correction rendered this non-significant (q=0.12), and no significant correlation was found with Fazekas grade (P = 0.068), suggesting limited association with WML severity in this cohort. CONCLUSION: This study suggests a potential neuroinflammatory profile in WML, characterized by coupled peripheral and central inflammation associated with gut-derived TMAO, though causality cannot be inferred from this cross-sectional design. CSF TNF-alpha and serum MMP-2 are proposed as precision biomarkers for stratifying WML severity. These findings should be interpreted as a hypothesis-generating framework integrating dysregulated gut-brain axis signaling, central cytokine surges, and blood-brain barrier disruption into a unified pathogenic cascade, providing mechanistic insights for targeted anti-inflammatory strategies in cerebrovascular disease. However, the clinical applicability requires further validation given the invasive nature of CSF collection. CI - Copyright (c) 2026 Cheng, Luo, Zhang, Xiao, An and Qu. FAU - Cheng, Xinxin AU - Cheng X AD - Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. FAU - Luo, Changjiang AU - Luo C AD - Department of Neurology, Jinan Shizhong District People's Hospital, Jinan, China. FAU - Zhang, Xudong AU - Zhang X AD - Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. FAU - Xiao, Huicong AU - Xiao H AD - Department of Neurology, The Third Affiliated Hospital of Shandong First Medical University, Jinan, China. FAU - An, Qi AU - An Q AD - Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. FAU - Qu, Chuanqiang AU - Qu C AD - Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China. LA - eng PT - Journal Article DEP - 20260508 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Biomarkers) RN - 0 (Methylamines) RN - FLD0K1SJ1A (trimethyloxamine) RN - 0 (Tumor Necrosis Factor-alpha) SB - IM MH - Humans MH - Male MH - Middle Aged MH - *Biomarkers/cerebrospinal fluid/blood MH - Female MH - Adult MH - *Methylamines/blood/cerebrospinal fluid MH - Cross-Sectional Studies MH - Aged MH - *White Matter/pathology/diagnostic imaging MH - Adolescent MH - *Neuroinflammatory Diseases/cerebrospinal fluid/blood MH - Severity of Illness Index MH - Young Adult MH - Blood-Brain Barrier/metabolism MH - Tumor Necrosis Factor-alpha/blood/cerebrospinal fluid PMC - PMC13193994 OTO - NOTNLM OT - blood-brain barrier OT - gut-brain axis OT - neuroinflammation biomarkers OT - trimethylamine N-oxide OT - white matter lesions COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/25 12:35 MHDA- 2026/05/25 12:36 PMCR- 2026/05/08 CRDT- 2026/05/25 08:17 PHST- 2026/01/30 00:00 [received] PHST- 2026/03/27 00:00 [revised] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/05/25 12:36 [medline] PHST- 2026/05/25 12:35 [pubmed] PHST- 2026/05/25 08:17 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1799968 [doi] PST - epublish SO - Front Immunol. 2026 May 8;17:1799968. doi: 10.3389/fimmu.2026.1799968. eCollection 2026. PMID- 42182060 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260525 LR - 20260813 IS - 1662-4548 (Print) IS - 1662-453X (Electronic) IS - 1662-453X (Linking) VI - 20 DP - 2026 TI - Estimation of head motion in structural MRI and its impact on cortical morphometry. PG - 1817743 LID - 10.3389/fnins.2026.1817743 [doi] LID - 1817743 AB - Motion-related artifacts are inevitable in Magnetic Resonance Imaging (MRI) and can bias automated neuroanatomical metrics such as cortical thickness. These biases can interfere with statistical analysis which is a major concern as motion has been shown to be more prominent in certain populations such as children or individuals with ADHD. Manual review cannot objectively quantify motion in anatomical scans, and existing quantitative automated approaches often require specialized hardware or custom acquisition protocols. Here, we train a 3D convolutional neural network to estimate a summary motion metric in retrospective routine research scans by leveraging a large training dataset of synthetically motion-corrupted volumes. We validate our method with one held-out site from our training cohort and with 14 fully independent datasets, including one with manual ratings, achieving a Spearman Rank correlation of 0.71 vs. manual labels. We also tested the correlation of our predicted motion score with morphometric measurements known to be impacted by motion, achieving significant correlation on most datasets. Furthermore, our predicted motion correlates with subject age in line with prior studies. Our approach shows good generalization across scanner brands and protocols, enabling objective, scalable motion assessment in structural MRI studies without prospective motion correction. Finally, we provide empirical evidence that our motion estimator significantly improve model fitness when studying cortical thickness and volume. Our final model is made openly and freely available through "Agitation," a tool usable as a CLI, python package and integrated in Nipoppy and Boutiques. By providing reliable motion estimates, our method offers researchers a tool to assess and account for potential biases in cortical morphometric analyses. CI - Copyright (c) 2026 Bricout, Ebrahimi Kahou and Bouix. FAU - Bricout, Charles AU - Bricout C AD - Ecole de Technologie Superieure, Montreal, QC, Canada. FAU - Ebrahimi Kahou, Samira AU - Ebrahimi Kahou S AD - Department of Electrical and Software Engineering, University of Calgary, Calgary, AB, Canada. AD - Canada Canadian Institute for Advanced Research (CIFAR) Artificial Intelligence (AI) Chair/Mila, Montreal, QC, Canada. FAU - Bouix, Sylvain AU - Bouix S AD - Ecole de Technologie Superieure, Montreal, QC, Canada. LA - eng PT - Journal Article DEP - 20260508 PL - Switzerland TA - Front Neurosci JT - Frontiers in neuroscience JID - 101478481 PMC - PMC13194591 OTO - NOTNLM OT - brain MRI OT - computer vision OT - cortical morphometry OT - deep learning OT - motion artifacts COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/25 12:35 MHDA- 2026/05/25 12:36 PMCR- 2026/05/08 CRDT- 2026/05/25 08:06 PHST- 2026/02/25 00:00 [received] PHST- 2026/04/06 00:00 [revised] PHST- 2026/04/07 00:00 [accepted] PHST- 2026/05/25 12:36 [medline] PHST- 2026/05/25 12:35 [pubmed] PHST- 2026/05/25 08:06 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - 10.3389/fnins.2026.1817743 [doi] PST - epublish SO - Front Neurosci. 2026 May 8;20:1817743. doi: 10.3389/fnins.2026.1817743. eCollection 2026. PMID- 42181574 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260525 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Diagnostic performance of wearable acoustic-electrocardiographic indices for screening secundum atrial septal defect in children. PG - 1774994 LID - 10.3389/fped.2026.1774994 [doi] LID - 1774994 AB - OBJECTIVE: To evaluate the diagnostic performance of acoustic-electrocardiographic indices derived from a wearable phonocardiogram-electrocardiogram (ECG) sensor for screening secundum atrial septal defect (ASD) in children. METHODS: In this cross-sectional study, 50 children (4-12 years) with secundum ASD and 50 age- and sex-matched healthy controls were enrolled. A wearable patch device recorded synchronized single-lead ECG and phonocardiogram, and S2 splitting time, S1-S2, S1-S2/RR (%), EMAT and EMAT/RR (%) were derived from artifact-free sinus beats at end-expiration. Group differences were assessed using independent-samples t-tests or chi (2) tests. Receiver operating characteristic analysis evaluated the ability of S2 splitting time and S1-S2/RR (%) to detect ASD, with optimal cut-offs defined by the Youden index. Multivariable logistic regression examined the independent association of these indices with ASD. RESULTS: Baseline demographic, anthropometric, and hemodynamic variables were well balanced between ASD and control groups. Compared with healthy controls, children with ASD had significantly prolonged S2 splitting time (39.65 +/- 8.37 vs. 28.20 +/- 8.91 ms; t = 6.623, P < 0.001) and an increased systolic fraction S1-S2/RR (%) (37.53 +/- 2.39% vs. 34.47 +/- 2.99%; t = 5.653, P < 0.001), whereas S1-S2 interval, EMAT, and EMAT/RR (%) did not differ significantly between groups. ROC analysis showed that S2 splitting time had good discriminative ability for detecting ASD, with an area under the curve (AUC) of 0.831 [95% confidence interval (CI): 0.752-0.910]. A cut-off value of >/=31.75 ms yielded a sensitivity of 0.90 and a specificity of 0.66. S1-S2/RR (%) demonstrated acceptable discrimination, with an AUC of 0.776 (95% CI 0.686-0.866) and an optimal cut-off of >/=35.25% (sensitivity 0.88, specificity 0.60). In multivariable logistic regression, both S2 splitting time [odds ratio (OR): 1.19 per 1-ms increase; 95% CI: 1.09-1.29; P < 0.001] and S1-S2/RR (%) (OR: 1.58 per 1% increase; 95% CI: 1.25-2.00; P < 0.001) remained independently associated with ASD. CONCLUSIONS: Wearable acoustic-electrocardiographic monitoring enables quantitative assessment of S2 splitting and systolic time fractions in children. Prolonged S2 splitting time and increased S1-S2/RR (%) are characteristic of secundum ASD and show good diagnostic performance, supporting these simple indices from a patch-type phonocardiogram-ECG sensor as a practical non-invasive tool for pediatric ASD screening. CI - (c) 2026 Pan, Zhang, Guo, Li, Chen, Niu, Zhang and Xiong. FAU - Pan, Jinyong AU - Pan J AD - Department of Pediatrics, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, China. FAU - Zhang, Fengling AU - Zhang F AD - Department of Pediatrics, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, China. FAU - Guo, Yan AU - Guo Y AD - Department of Pediatrics, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, China. FAU - Li, Hu AU - Li H AD - Department of Pediatrics, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, China. FAU - Chen, Yonglin AU - Chen Y AD - Department of Pediatrics, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, China. FAU - Niu, Muqing AU - Niu M AD - Department of Pediatrics, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, China. FAU - Zhang, Yan AU - Zhang Y AD - Department of Pediatrics, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, China. FAU - Xiong, Heyun AU - Xiong H AD - Department of Pediatrics, The First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang Uygur Autonomous Region, China. LA - eng PT - Journal Article DEP - 20260508 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13194352 OTO - NOTNLM OT - S2 splitting OT - atrial septal defect OT - electrocardiography OT - phonocardiography OT - systolic time intervals OT - wearable device COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/25 12:35 MHDA- 2026/05/25 12:36 PMCR- 2026/05/08 CRDT- 2026/05/25 08:01 PHST- 2025/12/24 00:00 [received] PHST- 2026/03/31 00:00 [revised] PHST- 2026/04/15 00:00 [accepted] PHST- 2026/05/25 12:36 [medline] PHST- 2026/05/25 12:35 [pubmed] PHST- 2026/05/25 08:01 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - 10.3389/fped.2026.1774994 [doi] PST - epublish SO - Front Pediatr. 2026 May 8;14:1774994. doi: 10.3389/fped.2026.1774994. eCollection 2026. PMID- 42181569 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260525 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Treatment of pediatric flatfoot: a systematic review-based consensus and guidelines by CPAM-LRC. PG - 1825355 LID - 10.3389/fped.2026.1825355 [doi] LID - 1825355 AB - The purpose of this clinical practice guideline is to provide evidence-based recommendations for the treatment of pediatric flexible flatfoot, developed in accordance with the Appraisal of Guidelines for Research and Evaluation II framework and with evidence certainty assessed using the GRADE framework and the Oxford Centre for Evidence-Based Medicine levels of evidence system. A multidisciplinary guideline development group under the Limb Reconstruction Committee of the Orthopedics Branch of China International Exchange and Promotion Association for Medical and Health Care systematically searched and reviewed evidence from primary studies including randomized controlled trials, cohort studies, and comparative studies, supplemented by existing systematic reviews and expert society surveys, to evaluate the effectiveness of conservative and surgical interventions and to guide clinicians and families on the content of an optimal treatment pathway. The guideline targets children and teenagers with flexible flatfoot and addresses interventions available to orthopedic surgeons, podiatrists, rehabilitation physicians, and orthotists, including observation, rehabilitative exercises, foot orthoses, subtalar arthroereisis, calcaneal osteotomy, and criterion-based progression to surgery. Structured conservative management should be considered the mainstay of care for all symptomatic children, with a minimum 6-month trial before surgical referral. However, there is limited evidence on the optimal type, dose, and duration of conservative treatment, and what constitutes an adequate trial of nonoperative care remains undefined. Foot orthoses can be helpful for symptomatic relief when pain or functional limitation is present, and rehabilitative exercise programs may allow superior normalization rates compared to orthoses alone. Pain-free ambulation and return to unrestricted sport are key milestones for both conservative and surgical pathways. However, no validated progression or discharge criteria exist to guide the transition from one treatment phase to the next. While the certainty of evidence was low to very low for most components of the treatment pathway, all 15 recommendation statements were formulated through two rounds of Delphi consensus polling, with 13 achieving the predefined >/=75% agreement threshold. This guideline also highlights the need for standardized diagnostic definitions, multicenter registry data, and age-stratified surgical indications not systematically addressed in previously published literature. CI - (c) 2026 Sharula, Zhao, Wu, Kang, Geng, Qin, Zhang, He, Huang, Xu and Lu. FAU - Sharula AU - Sharula AD - Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhao, Fei AU - Zhao F AD - Department of Orthopedics, Taihe Hospital Affiliated to Hubei University of Medicine, Shiyan, Hubei, China. FAU - Wu, Tianyi AU - Wu T AD - Department of Foot and Ankle Surgery, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Kang, Qinglin AU - Kang Q AD - Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Geng, Xiang AU - Geng X AD - Department of Foot and Ankle Surgery, Huashan Hospital, Fudan University, Shanghai, China. FAU - Qin, Hui AU - Qin H AD - Department of Pediatric Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhang, Yan AU - Zhang Y AD - Department of Pediatric Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - He, Jin AU - He J AD - Department of Orthopedics, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Huang, Lihua AU - Huang L AD - Department of Rehabilitation, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Xu, Jia AU - Xu J AD - Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Lu, Shengdi AU - Lu S AD - Department of Orthopedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Chronic Disease Epidemiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, United States. LA - eng PT - Journal Article PT - Review DEP - 20260508 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13194422 OTO - NOTNLM OT - calcaneal osteotomy OT - clinical practice guideline OT - delphi consensus OT - flexible pes planus OT - foot orthoses OT - pediatric flatfoot OT - subtalar arthroereisis COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/25 12:34 MHDA- 2026/05/25 12:35 PMCR- 2026/05/08 CRDT- 2026/05/25 08:01 PHST- 2026/03/07 00:00 [received] PHST- 2026/04/16 00:00 [revised] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/05/25 12:35 [medline] PHST- 2026/05/25 12:34 [pubmed] PHST- 2026/05/25 08:01 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - 10.3389/fped.2026.1825355 [doi] PST - epublish SO - Front Pediatr. 2026 May 8;14:1825355. doi: 10.3389/fped.2026.1825355. eCollection 2026. PMID- 42179331 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260813 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 83 IP - 2 DP - 2026 Aug TI - Improving nutritional assessment in pediatric anorexia nervosa: Clinical value of key serum biomarkers. PG - 324-330 LID - 10.1002/jpn3.70465 [doi] AB - OBJECTIVES: Reliable biochemical markers of starvation are needed to improve detection and monitoring of starvation in pediatric anorexia nervosa (AN), thus we explored new and revisited old potential serum biochemical markers. METHODS: In this prospective cohort study we included 65 pediatric patients with AN. Clinical data and serum at diagnosis were collected. Measured analytes included calcium, inorganic phosphate, alkaline phosphatase, albumin, transferrin, ceruloplasmin, prealbumin, C3 and C4 complement, ferritin, and vitamin D. Groups were compared by phenotype (classical AN vs. atypical anorexia nervosa [AAN]) and by severity of starvation (body mass index z-score: severe Z -2.0) using the Mann-Whitney test. Receiver operating characteristic (ROC) analysis assessed discriminatory performance. Moreover, sensitivity, specificity, positive predictive value, and negative predictive value were calculated. RESULTS: Median age was 15 years, 63 participants were female. Median symptom duration was 6 months and median weight loss 19.8% (z-score -2.03 +/- 1.40). Compared with classical AN, AAN patients had higher transferrin and C3 (p = 0.019 and p = 0.009). Severe malnutrition (Z 91%), NPVs varied significantly, being lowest in outpatient visits (41.3%). Temporally, NPV and sensitivity were lowest during April-June 2022 (57.7% and 14.9%, respectively), coinciding with the peak outbreak and the transition toward antigen-based diagnostic policies. Sensitivity was markedly higher among inpatients (84.4%) and older adults aged >/= 80 years (60.5%) compared to younger populations. CONCLUSION: ICD-10-CM U07.1 is a highly reliable marker for identifying confirmed COVID-19 cases in Taiwan's claims data. However, the low overall sensitivity and substantial variability in NPV suggest significant under-capture of mild infections, particularly in outpatient settings. Researchers should exercise caution when using this code to estimate total disease burden or when defining code-negative control cohorts. CI - (c) 2026. The Author(s). FAU - Chang, Wei-Lun AU - Chang WL AD - Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan. FAU - Wu, Chia-Ling AU - Wu CL AD - Center for Big Data Analytics and Statistics, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan. FAU - Chiu, Cheng-Hsun AU - Chiu CH AD - Division of Pediatric Infectious Diseases, Department of Pediatrics, Chang Gung Memorial Hospital, Linkou, Chang Gung University College of Medicine, Taoyuan, Taiwan. AD - Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan. FAU - Huang, Yu-Tung AU - Huang YT AD - National Center for Geriatrics and Welfare Research, National Health Research Institutes, No. 95-1, Xuefu Rd., Huwei Township, Yunlin County, 632007, Taiwan. anton.huang@gmail.com. LA - eng GR - CGRPG3Q0021/Chang Gung Medical Foundation, Taiwan/ PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20260523 PL - England TA - BMC Infect Dis JT - BMC infectious diseases JID - 100968551 SB - IM MH - Humans MH - Taiwan/epidemiology MH - *COVID-19/diagnosis/epidemiology MH - *International Classification of Diseases/standards MH - Female MH - SARS-CoV-2/isolation & purification/genetics MH - Middle Aged MH - Male MH - Aged MH - Adult MH - Sensitivity and Specificity MH - Aged, 80 and over MH - Adolescent MH - Young Adult MH - Databases, Factual PMC - PMC13383511 OTO - NOTNLM OT - Administrative claims data OT - COVID-19 OT - ICD-10-CM OT - Validation COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the Institutional Review Board of the Chang Gung Medical Foundation (IRB No. 202500368B0C6001). All data were fully de-identified prior to access and analysis; therefore, the requirement for informed consent was waived. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/24 04:38 MHDA- 2026/07/20 00:37 PMCR- 2026/05/23 CRDT- 2026/05/23 23:53 PHST- 2026/01/26 00:00 [received] PHST- 2026/05/13 00:00 [accepted] PHST- 2026/07/20 00:37 [medline] PHST- 2026/05/24 04:38 [pubmed] PHST- 2026/05/23 23:53 [entrez] PHST- 2026/05/23 00:00 [pmc-release] AID - 10.1186/s12879-026-13613-y [pii] AID - 13613 [pii] AID - 10.1186/s12879-026-13613-y [doi] PST - epublish SO - BMC Infect Dis. 2026 May 23;26(1):1368. doi: 10.1186/s12879-026-13613-y. PMID- 42177369 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260821 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 May 23 TI - Effects of exergames on depression, anxiety, and sleep in adolescents with subthreshold depression: a randomized controlled trial. LID - 10.1038/s41598-026-54710-x [doi] LID - 23603 AB - Subthreshold depression (SD) is highly prevalent among adolescents and increases the risk of developing major depressive disorder. Exergaming, an interactive form of digital physical activity, may enhance engagement and improve adherence compared with traditional exercise, making it a promising approach for adolescent mental-health promotion. This randomized controlled trial investigated the effects of an eight-week exergame intervention on depressive symptoms, anxiety, and sleep quality among adolescents with SD. A total of 51 students were randomly assigned to an exergame group (n = 26) or a control group (n = 25). Participants in the exergame group completed moderate-intensity exergaming for 40 min, two to three times per week, while the control group continued routine school activities. Mental-health outcomes were assessed before and after the intervention using validated self-report questionnaires, including the Self-Rating Depression Scale (SDS), the Self-Rating Anxiety Scale (SAS), and the Pittsburgh Sleep Quality Index (PSQI) for subjective sleep quality. After the 8-week intervention, the exergame group showed significantly greater improvements than the control group in depressive symptoms, anxiety, and sleep quality (all p < 0.05). These findings indicate that exergames are an engaging, feasible, and effective school-based strategy for improving mental health in adolescents with SD. As a low-threshold and scalable digital exercise modality, exergaming may offer meaningful benefits for early intervention and mental-health promotion in youth populations. CI - (c) 2026. The Author(s). FAU - Liu, Guofeng AU - Liu G AD - Department of Physical Education, Capital University of Physical Education and Sports, Beijing, China. AD - Department of Technician Education, Shandong Labor Vocational and Technical College, Jinan, Shandong, China. FAU - Jing, Yang AU - Jing Y AD - Department of Fundamental Education, Shandong Labor Vocational and Technical College, Jinan, Shandong, China. FAU - Xie, Jinjian AU - Xie J AD - Department of Technician Education, Shandong Labor Vocational and Technical College, Jinan, Shandong, China. FAU - Xie, Fei AU - Xie F AD - Department of Technician Education, Shandong Labor Vocational and Technical College, Jinan, Shandong, China. FAU - Chen, Dan AU - Chen D AD - Shengjing Primary School, Lixia District, Jinan, Shandong, China. FAU - Zhang, Junping AU - Zhang J AD - Department of Technician Education, Shandong Labor Vocational and Technical College, Jinan, Shandong, China. 13573147555@163.com. LA - eng GR - 2025SZ05/Shandong Labor Vocational and Technical College/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20260523 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Adolescent MH - *Anxiety/therapy MH - *Video Games MH - *Depression/therapy MH - Female MH - Male MH - *Sleep/physiology MH - Sleep Quality MH - *Exercise MH - *Exercise Therapy/methods MH - Surveys and Questionnaires PMC - PMC13421659 OTO - NOTNLM OT - Adolescents OT - Anxiety OT - Exergames OT - Sleep quality OT - Subthreshold depression COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/05/24 04:38 MHDA- 2026/07/30 00:38 PMCR- 2026/05/23 CRDT- 2026/05/23 23:20 PHST- 2025/11/26 00:00 [received] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/07/30 00:38 [medline] PHST- 2026/05/24 04:38 [pubmed] PHST- 2026/05/23 23:20 [entrez] PHST- 2026/05/23 00:00 [pmc-release] AID - 10.1038/s41598-026-54710-x [pii] AID - 54710 [pii] AID - 10.1038/s41598-026-54710-x [doi] PST - epublish SO - Sci Rep. 2026 May 23;16(1):23603. doi: 10.1038/s41598-026-54710-x. PMID- 42177225 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 May 23 TI - Longitudinal effects of physical activity on university students' mental health via self-efficacy and the moderating role of peer support. LID - 10.1038/s41598-026-53221-z [doi] LID - 23533 AB - To investigate the longitudinal mechanisms through which physical activity (PA) impacts students' mental health (well-being and emotional problems), and to systematically test the mediating role of self-efficacy alongside the moderating role of peer support. A two-wave longitudinal panel design with a 5-month time lag was conducted among 847 Chinese university students. Validated and culturally adapted scales were utilized to precisely assess physical activity (incorporating PE course exertion), well-being, emotional problems, general self-efficacy, and perceived peer support. Data were analyzed using Mplus 8.3 to construct cross-lagged panel models and longitudinal moderated mediation models, rigorously controlling for baseline variables and demographic covariates. (1) Cross-lagged analyses demonstrated that T1 physical activity significantly and positively predicted T2 well-being (beta = 0.15, p < 0.01) and negatively predicted T2 emotional problems (beta = -0.12, p < 0.01), with no significant reverse causality paths identified. (2) Longitudinal mediation analyses revealed that T2 self-efficacy fully mediated the pathways from physical activity to both mental health indicators, accounting for 61.8% and 64.3% of the total effects, respectively. Upon the inclusion of this mediator, the direct effects of physical activity on mental health were rendered non-significant. (3) Moderated mediation models confirmed that peer support significantly moderated the initial segment of the mediational chain (Physical Activity --> Self-efficacy; interaction term beta = 0.09, p < 0.01). Simple slope and conditional indirect effect analyses indicated that a high-level peer network synergistically amplified the efficiency with which physical activity translated into self-efficacy. Physical activity exerts a robust temporal protective effect on university students' mental health, a macro-level benefit realized primarily through the cultivation of deep-seated self-efficacy. Furthermore, a high-quality peer support environment serves as a critical socio-ecological catalyst that amplifies these psychological dividends. By partially addressing the temporal limitations of cross-sectional designs, this study provides empirical foundations for a psychologically-oriented paradigm shift in PE curricula and the development of cross-departmental synergistic interventions. CI - (c) 2026. The Author(s). FAU - Ma, Renjie AU - Ma R AD - School of Marxism, Zhengzhou University, Zhengzhou, 450001, China. FAU - Liu, Hongyuan AU - Liu H AD - Supercomputing Center in Zhengzhou, Zhengzhou University, Zhengzhou, 450001, China. AD - INTI International University Malaysia, Nilai, 71800, Malaysia. FAU - Shi, Mengyu AU - Shi M AD - Physical Education and Training Institute, Capital University of Physical Education and Sports, Beijing, 102600, China. FAU - Zhu, Qiuhan AU - Zhu Q AD - School of Kinesiology and Physical Education, Zhengzhou University, Zhengzhou, 450001, China. zhuqiuhan@zzu.edu.cn. LA - eng GR - 23CTY011/Research on the Resilience of Urban Community Sports Social Organizations in China and the Modernization of Their Governance Capacity/ PT - Journal Article DEP - 20260523 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Self Efficacy MH - *Students/psychology MH - *Mental Health MH - Female MH - Male MH - *Exercise/psychology MH - Universities MH - Longitudinal Studies MH - *Social Support MH - *Peer Group MH - Young Adult MH - Adult MH - Adolescent PMC - PMC13415835 OTO - NOTNLM OT - Cross-lagged panel model OT - Longitudinal study OT - Mental health OT - Peer support OT - Physical activity OT - Self-efficacy COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics: The studies involving human participants were reviewed and approved by the Ethics Committee of Zhengzhou University. The study was conducted in accordance with the Declaration of Helsinki. The participants provided their written informed consent to participate in this study. Financial disclosure: This research is funded by the project "Research on the Resilience of Urban Community Sports Social Organizations in China and the Modernization of Their Governance Capacity" (Grant No. 23CTY011). EDAT- 2026/05/24 04:38 MHDA- 2026/07/30 00:38 PMCR- 2026/05/23 CRDT- 2026/05/23 23:15 PHST- 2026/02/12 00:00 [received] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/07/30 00:38 [medline] PHST- 2026/05/24 04:38 [pubmed] PHST- 2026/05/23 23:15 [entrez] PHST- 2026/05/23 00:00 [pmc-release] AID - 10.1038/s41598-026-53221-z [pii] AID - 53221 [pii] AID - 10.1038/s41598-026-53221-z [doi] PST - epublish SO - Sci Rep. 2026 May 23;16(1):23533. doi: 10.1038/s41598-026-53221-z. PMID- 42176987 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260823 IS - 1541-6100 (Electronic) IS - 0022-3166 (Print) IS - 0022-3166 (Linking) VI - 156 IP - 7 DP - 2026 Jul TI - Total Sugars Misreporting in Self-Reported 24-Hour Recalls in the Study of Latinos: Nutrition and Physical Activity Assessment Study. PG - 101608 LID - S0022-3166(26)00257-9 [pii] LID - 10.1016/j.tjnut.2026.101608 [doi] AB - BACKGROUND: Hispanic and Latinos living in the United States bear a disproportionate burden of chronic diseases previously associated with sugars intake. However, due to measurement error (ME) in self-reported diet, these associations have been difficult to establish. OBJECTIVES: To study ME of self-reported total sugars (TSs) intake, as well as its determinates and effect on estimating diet-disease associations in Hispanics and Latinos living in the United States, we apply the 24-h urinary sucrose and fructose predictive biomarker previously confirmed in a feeding study under United States diet. METHODS: We used data from 443 males and females aged 18 to 74 y of Central American, Cuban, Dominican, Mexican, Puerto Rican, and South American origin living across 4 United States communities who participated in the Study of Latinos: Nutrition and Physical Activity Assessment Study (SOLNAS). Participants completed 3 24-h recalls (24HR) and 1 24-h urine collection for measurement of 24-h urinary sucrose and fructose biomarker. Doubly labeled water was administered once to estimate energy intake. Measures were repeated 6 mo later in a reliability sample (n = 81). ME structure in self-reported TSs was investigated using a time-varying intake ME model adjusted for sex, age, and body mass index. RESULTS: The biomarker-based TSs intake was 171.3 g/d (95% confidence interval: 158.3-185.3) compared with 96.3 g/d (95% confidence interval: 91.7-101.2) estimated by 3 24HRs. The correlation of true intake with mean TSs from 2 24HRs as a measure of usual intake over 0 to 12 mo ranged from 0.19 to 0.21. The attenuation factors for the average of 2 24HRs ranged from 0.08 to 0.16. Age and Hispanic and Latino background were significantly associated with TSs misreporting, whereas, age, Hispanic and Latino background, being male and supplement user were associated with misreporting of TSs density. CONCLUSIONS: In this Hispanic and Latino population, we observed large ME in 24HR-measured TSs consumption that would lead to severe attenuation of estimated risk in future sugars-disease association studies. Applying biomarker-based ME correction approaches may alleviate bias. CI - Copyright (c) 2026 American Society for Nutrition. All rights reserved. FAU - Tasevska, Natasha AU - Tasevska N AD - College of Health Solutions, Arizona State University, Phoenix, AZ, United States. Electronic address: Natasha.Tasevska@asu.edu. FAU - Mossavar-Rahmani, Yasmin AU - Mossavar-Rahmani Y AD - Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, United States. FAU - Midthune, Douglas AU - Midthune D AD - Division of Cancer Prevention, National Cancer Institute, Rockville, MD, United States. FAU - Barrett, Brian AU - Barrett B AD - Information Management Services Inc., Rockville, MD, United States. FAU - Razis, Spiro AU - Razis S AD - Information Management Services Inc., Rockville, MD, United States. FAU - Kipnis, Victor AU - Kipnis V AD - Division of Cancer Prevention, National Cancer Institute, Rockville, MD, United States. FAU - Kaplan, Robert AU - Kaplan R AD - Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, United States. FAU - O'Brien, Diane AU - O'Brien D AD - Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK, United States. FAU - Park, Yikyung AU - Park Y AD - Division of Public Health Sciences, Washington University School of Medicine in St. Louis, St. Louis, MO, United States. FAU - Beasley, Jeannette AU - Beasley J AD - Department of Medicine, New York University, New York, NY, United States. FAU - Van Horn, Linda AU - Van Horn L AD - Feinberg School of Medicine, Northwestern University, Chicago, IL, United States. FAU - Daviglus, Martha AU - Daviglus M AD - Department of Medicine, University of Illinois Chicago, Chicago, IL, United States. FAU - Sotres-Alvarez, Daniela AU - Sotres-Alvarez D AD - Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States. FAU - Freedman, Laurence S AU - Freedman LS AD - Gertner Institute for Epidemiology and Health Policy Research, Sheba Medical Center, Tel Hashomer, Israel. LA - eng GR - HHSN268201300005C/HL/NHLBI NIH HHS/United States GR - HHSN268201300004C/HL/NHLBI NIH HHS/United States GR - HHSN268201300003I/HL/NHLBI NIH HHS/United States GR - N01 HC065233/HL/NHLBI NIH HHS/United States GR - N01 HC065236/HL/NHLBI NIH HHS/United States GR - N01 HC065235/HL/NHLBI NIH HHS/United States GR - HHSN268201300001C/HB/NHLBI NIH HHS/United States GR - N01 HC065234/HL/NHLBI NIH HHS/United States GR - R01 HL095856/HL/NHLBI NIH HHS/United States GR - U01 CA197902/CA/NCI NIH HHS/United States GR - HHSN268201300003C/HG/NHGRI NIH HHS/United States GR - N01 HC065237/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260522 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 RN - 0 (Biomarkers) RN - 0 (Dietary Sugars) RN - 30237-26-4 (Fructose) SB - IM MH - Humans MH - Female MH - Male MH - *Hispanic or Latino MH - *Self Report MH - Middle Aged MH - Adult MH - Mental Recall MH - Biomarkers/urine MH - Adolescent MH - Aged MH - *Dietary Sugars/administration & dosage MH - Young Adult MH - United States MH - Nutrition Assessment MH - Fructose/urine MH - Energy Intake MH - Diet MH - Reproducibility of Results PMC - PMC13410787 MID - NIHMS2186708 OTO - NOTNLM OT - 24-h urine biomarker OT - Hispanics OT - SOLNAS OT - measurement error OT - total sugars COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/05/24 04:38 MHDA- 2026/07/08 12:55 PMCR- 2026/07/28 CRDT- 2026/05/23 19:33 PHST- 2026/01/28 00:00 [received] PHST- 2026/04/21 00:00 [revised] PHST- 2026/05/18 00:00 [accepted] PHST- 2026/07/08 12:55 [medline] PHST- 2026/05/24 04:38 [pubmed] PHST- 2026/05/23 19:33 [entrez] PHST- 2026/07/28 00:00 [pmc-release] AID - S0022-3166(26)00257-9 [pii] AID - 10.1016/j.tjnut.2026.101608 [doi] PST - ppublish SO - J Nutr. 2026 Jul;156(7):101608. doi: 10.1016/j.tjnut.2026.101608. Epub 2026 May 22. PMID- 42176141 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260523 LR - 20260813 IS - 2194-7791 (Print) IS - 2194-7791 (Electronic) IS - 2194-7791 (Linking) VI - 13 IP - 1 DP - 2026 May 23 TI - LEF1 gene mutation impairs the intestinal barrier and causes diarrhea. LID - 10.1186/s40348-026-00240-5 [doi] LID - 29 AB - Whole-exome sequencing identified a novel de novo heterozygous LEF1 variant (c.880 C > T; p.Pro294Ser) in a male pediatric patient who presented with intractable chronic yellow-green watery diarrhea with onset at 18 months of age. The condition persisted for 4 years and was complicated by protein-energy malnutrition and growth failure refractory to standard therapy. Gastrointestinal endoscopy showed mucosal edema accompanied by mild chronic inflammation, and this variant was not present in public population genomic databases. Functional validation was performed in Lef1 (c.876 C > G; p.Pro292Ser) knock-in mice (the murine ortholog of the human LEF1 p.Pro294Ser variant), and revealed increased susceptibility to dextran sulfate sodium (DSS)-induced diarrhea, intrinsic intestinal structural abnormalities, and impaired intestinal barrier integrity. Molecular and proteomic analyses revealed downregulated expression of tight junction proteins and aquaporin - 4 in both mutant mice and patient-derived intestinal tissues, concomitant with dysregulated ion transport, and aberrant inflammatory pathways. Mechanistically, the LEF1 variant enhances its own expression and nuclear accumulation, driving Epithelial-Mesenchymal Transition (EMT) and subsequent intestinal barrier disruption. Collectively, these findings establish LEF1 variant as a pathogenic driver of pediatric chronic diarrhea, broaden the functional role of LEF1 in intestinal homeostasis, and identifies its potential utility as a diagnostic biomarker and therapeutic target for this disorder. CI - (c) 2026. The Author(s). FAU - Jie, Jianan AU - Jie J AD - Department of Gastroenterology, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510120, China. FAU - Qiu, Mengling AU - Qiu M AD - Department of Gastroenterology, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510120, China. FAU - Liu, Xing AU - Liu X AD - Department of Gastroenterology, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510120, China. FAU - Zhang, Qingqing AU - Zhang Q AD - Department of Gastroenterology, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510120, China. FAU - Xie, Jing AU - Xie J AD - Department of Gastroenterology, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510120, China. FAU - Geng, Lanlan AU - Geng L AD - Department of Gastroenterology, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510120, China. genglan_2001@hotmail.com. FAU - Gong, Sitang AU - Gong S AD - Department of Gastroenterology, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510120, China. sitangg@126.com. FAU - Cheng, Yang AU - Cheng Y AD - Department of Gastroenterology, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510120, China. chengyang2872@sina.com. LA - eng PT - Journal Article DEP - 20260523 PL - Germany TA - Mol Cell Pediatr JT - Molecular and cellular pediatrics JID - 101660689 PMC - PMC13198594 OTO - NOTNLM OT - Diarrhea OT - Intestinal Barrier OT - LEF1 OT - Mutation COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/05/24 04:36 MHDA- 2026/05/24 04:37 PMCR- 2026/05/23 CRDT- 2026/05/23 11:07 PHST- 2025/12/29 00:00 [received] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/05/24 04:37 [medline] PHST- 2026/05/24 04:36 [pubmed] PHST- 2026/05/23 11:07 [entrez] PHST- 2026/05/23 00:00 [pmc-release] AID - 10.1186/s40348-026-00240-5 [pii] AID - 240 [pii] AID - 10.1186/s40348-026-00240-5 [doi] PST - epublish SO - Mol Cell Pediatr. 2026 May 23;13(1):29. doi: 10.1186/s40348-026-00240-5. PMID- 42175408 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 21 DP - 2026 May 22 TI - Red blood cell distribution width in pediatric congenital heart disease: A review of clinical applications. PG - e48937 LID - 10.1097/MD.0000000000048937 [doi] LID - e48937 AB - Congenital heart disease (CHD) encompasses a heterogeneous spectrum of anatomical lesions ranging from simple shunts to complex cyanotic malformations, representing the most common congenital anomaly in children with variable clinical outcomes. Red blood cell distribution width (RDW), an indicator of erythrocyte volume heterogeneity, has demonstrated associations with cardiac dysfunction across diverse CHD phenotypes. This review synthesizes evidence (2015-2023) from PubMed, Web of Science, Cochrane Library, and China National Knowledge Infrastructure regarding RDW's clinical utility in pediatric CHD. Current evidence indicates that elevated RDW correlates with disease severity, particularly in heart failure and pulmonary hypertension cohorts, and shows potential for perioperative risk stratification (e.g., prolonged mechanical ventilation). However, reported cutoff values vary substantially across studies (13.9%-16.0%), likely reflecting the anatomical and physiological heterogeneity of CHD populations - wherein RDW elevation in cyanotic lesions may reflect chronic hypoxia-driven erythropoiesis, while in acyanotic shunts it indicates volume overload-mediated inflammation. Existing data predominantly derive from retrospective, single-center studies lacking anatomical stratification, limiting causal inference. RDW serves as an inexpensive, accessible biomarker for risk assessment in resource-limited settings, though interpretation requires contextualization by specific CHD subtype and confounding factors (anemia, nutritional status). Future prospective multicenter studies must establish anatomy-specific reference ranges and validate temporal predictive utility through stratified analyses of simple versus complex lesions, cyanotic versus acyanotic physiology, and preoperative versus postoperative stages. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Xu, Shuqiong AU - Xu S AD - Department of Pediatrics, West China Hospital Sichuan University Jintang/Jintang First People's Hospital, Chengdu, Sichuan, China. FAU - Wang, Junru AU - Wang J AD - Department of Pediatrics, West China Hospital Sichuan University Jintang/Jintang First People's Hospital, Chengdu, Sichuan, China. FAU - Yin, Jun AU - Yin J AD - Department of Ultrasound, West China Hospital Sichuan University Jintang/Jintang First People's Hospital, Chengdu, Sichuan, China. FAU - Cao, Yongyu AU - Cao Y AD - Pediatric Cardiology Center, Medical Sichuan Provincial Women's and Children's Hospital/The Affiliated Women's and Children's Hospital of Chengdu College, Chengdu, Sichuan, China. FAU - Luo, Tongyong AU - Luo T AD - Pediatric Cardiology Center, Medical Sichuan Provincial Women's and Children's Hospital/The Affiliated Women's and Children's Hospital of Chengdu College, Chengdu, Sichuan, China. FAU - Wang, Xianmin AU - Wang X AUID- ORCID: 0009-0001-3993-8480 AD - Pediatric Cardiology Center, Medical Sichuan Provincial Women's and Children's Hospital/The Affiliated Women's and Children's Hospital of Chengdu College, Chengdu, Sichuan, China. FAU - Wang, Qingsong AU - Wang Q AUID- ORCID: 0009-0006-8574-7737 AD - Department of Pediatrics, West China Hospital Sichuan University Jintang/Jintang First People's Hospital, Chengdu, Sichuan, China. LA - eng PT - Journal Article PT - Review PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Heart Defects, Congenital/blood/physiopathology MH - *Erythrocyte Indices/physiology MH - Child MH - *Erythrocytes MH - Biomarkers/blood MH - Risk Assessment PMC - PMC13201050 OTO - NOTNLM OT - cardiac function OT - congenital heart disease OT - red blood cell distribution width COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2026/05/23 06:33 MHDA- 2026/05/23 06:34 PMCR- 2026/05/22 CRDT- 2026/05/23 01:03 PHST- 2025/01/02 00:00 [received] PHST- 2026/05/03 00:00 [accepted] PHST- 2026/05/23 06:34 [medline] PHST- 2026/05/23 06:33 [pubmed] PHST- 2026/05/23 01:03 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - 00005792-202605220-00013 [pii] AID - MD-D-24-16457 [pii] AID - 10.1097/MD.0000000000048937 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 May 22;105(21):e48937. doi: 10.1097/MD.0000000000048937. PMID- 42174679 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260827 IS - 1749-799X (Electronic) IS - 1749-799X (Linking) VI - 21 IP - 1 DP - 2026 May 22 TI - Comparison of radiographic parameters between sciatic scoliosis and Lenke 5/6 type idiopathic scoliosis in young patients: a LASSO and nomogram analysis. LID - 10.1186/s13018-026-06893-2 [doi] LID - 503 AB - OBJECTIVES: To compare radiographic parameters between sciatic scoliosis (SS) and Lenke 5/6 idiopathic scoliosis (IS) in young patients and to develop a predictive model. METHODS: A total of 148 patients (SS: IS = 75:73) were retrospectively enrolled. Demographic data and preoperative radiographic parameters were recorded. Univariate analysis was conducted between the two groups. Least Absolute Shrinkage and Selection Operator (LASSO) regression and logistic regression were used to screen for risk factors, and a nomogram designed to differentiate the two types of scoliosis was further constructed. Model performance was evaluated using the area under the receiver operating characteristic curve (AUC), calibration curves, and decision curve analysis (DCA), with bootstrap resampling (1000 iterations). RESULTS: Compared with the IS group, the SS group was found to have a smaller lumbar lordosis (LL) and vertebral rotation, but larger pelvic tilt (PT) and coronal trunk shift (all p < 0.05). LASSO regression retained five variables, while logistic regression identified body mass index (BMI), LL, and mean vertebrae rotation (MVR) as independent predictors. The nomogram based on these predictors achieved an AUC of 0.957 (95% CI: 0.930-0.983) and showed good calibration (mean absolute error = 0.019). CONCLUSIONS: BMI, LL, and MVR are accurate, reliable predictors for distinguishing SS from Lenke 5/6 IS in young patients, providing a diagnostic basis for clinical practice. CI - (c) 2026. The Author(s). FAU - Xu, Zhongning AU - Xu Z AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, No. 31, Xinjiekou East Street, Xicheng District, Beijing, 100035, China. FAU - Ao, Jintao AU - Ao J AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, No. 31, Xinjiekou East Street, Xicheng District, Beijing, 100035, China. FAU - Zhang, Yanbin AU - Zhang Y AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, No. 31, Xinjiekou East Street, Xicheng District, Beijing, 100035, China. FAU - Xiao, Bin AU - Xiao B AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, No. 31, Xinjiekou East Street, Xicheng District, Beijing, 100035, China. FAU - Jiang, Jile AU - Jiang J AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, No. 31, Xinjiekou East Street, Xicheng District, Beijing, 100035, China. jile.jiang@gmail.com. FAU - Sun, Yuqing AU - Sun Y AD - Department of Spine Surgery, Beijing Jishuitan Hospital, Capital Medical University, No. 31, Xinjiekou East Street, Xicheng District, Beijing, 100035, China. syuqing2004@126.com. LA - eng GR - YGLX202511/Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support/ PT - Comparative Study PT - Journal Article DEP - 20260522 PL - England TA - J Orthop Surg Res JT - Journal of orthopaedic surgery and research JID - 101265112 SB - IM MH - Humans MH - *Scoliosis/diagnostic imaging/classification MH - *Nomograms MH - Female MH - Retrospective Studies MH - Male MH - Adolescent MH - Child MH - Radiography/methods MH - Lumbar Vertebrae/diagnostic imaging PMC - PMC13505042 OTO - NOTNLM OT - EOS images OT - Idiopathic scoliosis OT - LASSO analysis OT - Nomogram OT - Sciatic scoliosis COIS- Declarations. Ethical approval and consent to participate: The study received approval from the Ethics Committee of Beijing Jishuitan Hospital (JL-K2024-172-00) and adhered to the Declaration of Helsinki. All participants included in this study have obtained informed consent and agreed to the publication of the article. Consent for publication: All authors have read and approved the final manuscript. Competing interests: The authors declare no competing interests. EDAT- 2026/05/23 06:32 MHDA- 2026/08/25 05:34 PMCR- 2026/05/22 CRDT- 2026/05/23 00:21 PHST- 2025/11/26 00:00 [received] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/08/25 05:34 [medline] PHST- 2026/05/23 06:32 [pubmed] PHST- 2026/05/23 00:21 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - 10.1186/s13018-026-06893-2 [pii] AID - 6893 [pii] AID - 10.1186/s13018-026-06893-2 [doi] PST - epublish SO - J Orthop Surg Res. 2026 May 22;21(1):503. doi: 10.1186/s13018-026-06893-2. PMID- 42174583 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261021 IS - 1741-7015 (Electronic) IS - 1741-7015 (Linking) VI - 24 IP - 1 DP - 2026 May 22 TI - Quantitative assessment of efficacy and evaluation of feasibility of exercise training protocols in adult and pediatric primary mitochondrial disease. LID - 10.1186/s12916-026-04944-3 [doi] LID - 555 AB - BACKGROUND: Exercise has been demonstrated to be effective in the general population and in a small number of Primary Mitochondrial Disease (PMD) human studies, raising the potential of exercise as standard of care in PMD. However, standardized exercise prescriptions have not been established in this heterogeneous patient population. This study aimed to identify effective and feasible exercise training protocols, to inform the design of rigorous exercise studies in adults and/or children with PMD. This was achieved through integration of a structured feasibility evaluation preceded by a quantitative review of published PMD studies, with specific focus on subgroup analyses by exercise type (aerobic, resistance, interval, and combination exercise). METHODS: A systematic literature review was conducted to identify published exercise studies in PMD cohorts. Due to the limited number of PMD exercise studies, the search was expanded to include disorders with secondary mitochondrial dysfunction (SMD), with similar symptoms of muscle weakness, muscle fatigue and exercise intolerance, as occurs in PMD. In total, 77 studies comprising 109 exercise training protocols were identified. Of those, a quantitative analysis was performed on 37 PMD and SMD studies reporting key outcome measures to assess the effects of aerobic, resistance, combination or interval exercise training. All 109 exercise training protocols were then systematically evaluated for feasibility, as defined by the likelihood of successful implementation in future exercise studies of PMD, using a standardized scoring system. RESULTS: Results of our quantitative analysis demonstrate the significant effect of distinct exercise types including aerobic exercise training on relative peak oxygen consumption (VO(2)), peak work, and Short-Form 36 (SF-36) physical summary score; and combination (interval/resistance/inspiratory muscle training) exercise training on relative peak VO(2) and SF-36 across PMD studies. Feasibility evaluation across PMD and SMD studies involving expert group consensus review identified high-intensity circuit training (HICT), low-intensity steady-state (LISS) aerobic exercise, low-intensity resistance training, and blood flow restriction resistance training (BFR-RT) as being potentially feasible and effective in PMD. CONCLUSIONS: Results of this study highlight specific exercise training protocols that merit assessment in future rigorously designed exercise studies to determine their feasibility and therapeutic efficacy in adults and/or children with PMD. CI - (c) 2026. The Author(s). FAU - Martin, Isaac AU - Martin I AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Flickinger, Jean AU - Flickinger J AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. AD - Center for Rehabilitation, Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Rahaman, Imon AU - Rahaman I AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Sarna, Tejas AU - Sarna T AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Ballance, Elizabeth B AU - Ballance EB AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. AD - Center for Rehabilitation, Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Ginelli, Nicholas AU - Ginelli N AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Peterson, James T AU - Peterson JT AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. FAU - Uryash, Arkady AU - Uryash A AD - Division of Neonatology, Mount Sinai Medical Center, Miami Beach, FL, USA. AD - Semyon and Janna Friedman Advanced Research Institute, Miami Beach, FL, USA. FAU - Adams, Jose A AU - Adams JA AD - Division of Neonatology, Mount Sinai Medical Center, Miami Beach, FL, USA. AD - Semyon and Janna Friedman Advanced Research Institute, Miami Beach, FL, USA. FAU - Xiao, Rui AU - Xiao R AD - Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania Philadelphia, Philadelphia, PA, USA. AD - Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. FAU - Zolkipli-Cunningham, Zarazuela AU - Zolkipli-Cunningham Z AD - Mitochondrial Medicine Frontier Program, Division of Genetic and Genomic Medicine, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. zolkipliz@chop.edu. AD - Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. zolkipliz@chop.edu. AD - Center for Epigenomic and Mitochondrial Medicine, The Children's Hospital of Philadelphia, Philadelphia, PA, USA. zolkipliz@chop.edu. LA - eng GR - R01 AR083552/AR/NIAMS NIH HHS/United States GR - U54 NS078059/NS/NINDS NIH HHS/United States GR - 1R01AR083552-01A1/AR/NIAMS NIH HHS/United States GR - NIH U54NS078059/North American Mitochondrial Disease Consortium/ PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Systematic Review DEP - 20260522 PL - England TA - BMC Med JT - BMC medicine JID - 101190723 SB - IM MH - Humans MH - *Mitochondrial Diseases/therapy/rehabilitation/physiopathology MH - Child MH - Adult MH - *Exercise Therapy/methods MH - Feasibility Studies MH - Treatment Outcome PMC - PMC13651422 OTO - NOTNLM OT - Aerobic training OT - Exercise intervention OT - Mitochondrial Myopathy OT - Outcome measures. OT - Primary Mitochondrial Disease OT - Resistance training COIS- Declarations. Ethical approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Authors information: Not applicable. EDAT- 2026/05/23 06:33 MHDA- 2026/10/09 05:30 PMCR- 2026/05/22 CRDT- 2026/05/23 00:18 PHST- 2025/08/18 00:00 [received] PHST- 2026/05/14 00:00 [accepted] PHST- 2026/10/09 05:30 [medline] PHST- 2026/05/23 06:33 [pubmed] PHST- 2026/05/23 00:18 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - 10.1186/s12916-026-04944-3 [pii] AID - 4944 [pii] AID - 10.1186/s12916-026-04944-3 [doi] PST - epublish SO - BMC Med. 2026 May 22;24(1):555. doi: 10.1186/s12916-026-04944-3. PMID- 42174517 OWN - NLM STAT- Publisher LR - 20260523 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) DP - 2026 May 22 TI - Impact of sugar consumption on dental caries in children and adolescents: a systematic review of frequency versus quantity. LID - 10.1186/s12889-026-27780-9 [doi] AB - BACKGROUND: Excessive sugar consumption is a well-established risk factor for dental caries, particularly in pediatric populations. This systematic review explores the relationship between sugar consumption and the development of dental caries in children and adolescents. METHODS: This review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was prospectively registered (PROSPERO, CRD420250619741). A comprehensive search of PubMed, Web of Science, Scopus, Embase, and SciELO was performed. Observational studies involving children and adolescents (/= 100 ml and preoperative hypothalamic injury and T-type tumors were higher in HO group. Small tumors (< 5 cm(3)) were less frequent in HO group (all P < 0.05). Logistic regression analysis showed that preoperative high BMI and intraoperative blood loss >/= 100 ml were independent risk factors for postoperative HO, while older age at onset and smaller tumor size were protective factors (all P < 0.05). The model developed from the training cohort showed that the area under the receiver operating characteristic curve (AUC) was 0.865(95%CI of 0.793 ~ 0.937), with a sensitivity of 79.5% and a specificity of 80.8%, the validation cohort had an AUC of 0.864(95%CI:0.744-0.983), with a sensitivity of 90.9% and a specificity of 72.2%. The calibration curve and Hosmer-Lemeshow test demonstrated that the predicted value of the model was in agreement with the observed values in both the training and verification cohorts (P > 0.05). CONCLUSION: Preoperative high BMI and intraoperative blood loss >/= 100 ml are independent risk factors for HO after craniopharyngioma surgery. A predictive model based on preoperative BMI, age at onset, intraoperative blood loss, and tumor size shows potential for predicting the risk of postoperative HO, aiding in early identification for high-risk patients. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2026. The Author(s). FAU - Li, Qianshuai AU - Li Q AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Zhao, Linlin AU - Zhao L AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Huang, Fengjuan AU - Huang F AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Gong, Xuyang AU - Gong X AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Pan, Mengxing AU - Pan M AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Liu, Xinjing AU - Liu X AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Wang, Tianfang AU - Wang T AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Li, Xulong AU - Li X AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Xie, Yijing AU - Xie Y AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Gao, Ankang AU - Gao A AD - Department of Magnetic Resonance, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Zhang, Yong AU - Zhang Y AD - Department of Magnetic Resonance, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. FAU - Zhao, Yanyan AU - Zhao Y AD - Department of Endocrinology and Metabolic Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China. fcczhaoyy1@zzu.edu.cn. AD - Henan Key Laboratory of Chronic Disease Prevention and Therapy & Intelligent Health Management, Zhengzhou, Henan, 450052, China. fcczhaoyy1@zzu.edu.cn. AD - Henan Institute of Interconnected Intelligent Health Management, Zhengzhou, Henan, 450052, China. fcczhaoyy1@zzu.edu.cn. LA - eng GR - 242300421272/Natural Science Foundation of Henan Province/ GR - QNCXTD2023015/Research and Innovation Team Project of the First Affiliated Hospital of Zhengzhou University/ GR - 82470876/National Natural Science Foundation of China/ PT - Journal Article PT - Validation Study DEP - 20260522 PL - England TA - BMC Endocr Disord JT - BMC endocrine disorders JID - 101088676 SB - IM MH - Humans MH - *Craniopharyngioma/surgery/pathology MH - Female MH - Retrospective Studies MH - *Pituitary Neoplasms/surgery/pathology MH - *Postoperative Complications/diagnosis/etiology/epidemiology MH - *Obesity/etiology/diagnosis/epidemiology MH - Male MH - Risk Factors MH - *Hypothalamic Diseases/etiology/diagnosis MH - Follow-Up Studies MH - Prognosis MH - Body Mass Index MH - Adolescent MH - Adult MH - Young Adult MH - Child MH - *Neurosurgical Procedures/adverse effects PMC - PMC13218063 OTO - NOTNLM OT - Body mass index OT - Hypothalamic obesity OT - Postoperative craniopharyngioma OT - Predictive model COIS- Declarations. Human ethics and consent to participate: The study was performed in line with the principles of the Decleration of Helsinki. The study was approved by the ethics committee of the First Affiliated Hospital of Zhengzhou University (No. KY-2024-KY-1086). In compliance with national law and institutional standards, written informed consent was not required and was waived by the ethics committee for this retrospective study. Consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/23 06:31 MHDA- 2026/05/29 15:44 PMCR- 2026/05/22 CRDT- 2026/05/23 00:16 PHST- 2026/02/23 00:00 [received] PHST- 2026/05/13 00:00 [accepted] PHST- 2026/05/29 15:44 [medline] PHST- 2026/05/23 06:31 [pubmed] PHST- 2026/05/23 00:16 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - 10.1186/s12902-026-02322-x [pii] AID - 2322 [pii] AID - 10.1186/s12902-026-02322-x [doi] PST - epublish SO - BMC Endocr Disord. 2026 May 22;26(1):164. doi: 10.1186/s12902-026-02322-x. PMID- 42174465 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 May 22 TI - Development of an interpretable machine learning model for predicting stress urinary incontinence following the delivery of a first child. LID - 10.1186/s12884-026-09285-w [doi] LID - 725 AB - INTRODUCTION: The goal of this research is to use machine learning (ML) techniques to create a risk prediction model for postpartum stress urinary incontinence (PSUI). To improve screening accuracy and optimize clinical care techniques, the goal is to determine the best model for clinical screening. METHODS: Telephone interviews and computerized medical records were used in this study to gather data, which was then combined into a follow-up data form. We recruited women who underwent surface electromyography (sEMG) at Xinjiang Production and Construction Corps Hospital's postpartum rehabilitation clinic between January 2020 and January 2025. A total of 449 primiparous women were included in the study after the inclusion and exclusion criteria were applied. A training set and a validation set were randomly selected from the dataset in a 7:3 ratio. Predictive models for persistent postpartum stress urinary incontinence (PSUI) were created using five machine learning algorithms: logistic regression, decision tree, random forest, support vector machine (SVM), and extreme gradient boosting (XGBoost). Model performance was evaluated using metrics including the area under the receiver operating characteristic curve (AUC). Model interpretability was achieved through SHapley Additive exPlanations (SHAP) analysis. RESULTS: Eight features were kept in the final model: neonatal birth weight, pre-pregnancy BMI, age at delivery, perineal laceration, mean pre-resting phase, mean post-resting phase, maximum fast-twitch phase, and mean slow-twitch phase. Out of the five algorithms, the Random Forest model performed the best, with a test set AUC of 0.920 (95% CI 0.8704-0.9688, P < 0.05), accuracy of 0.8444, precision of 0.6341, recall of 0.8125, specificity of 0.8544, and an F1 score of 0.7123. Ten-fold cross-test and the test set were used to confirm the model's strong generalizability. CONCLUSION: Strong clinical potential for PSUI risk prediction and screening is demonstrated by the random forest model. To further improve the model's clinical usefulness, future research should increase the sample size and include multicenter data. CI - (c) 2026. The Author(s). FAU - Tian, Siwen AU - Tian S AD - The Graduate School of Xinjiang Medical University, Urumqi, 830011, China. FAU - Sha, Jing AU - Sha J AD - Xinjiang Production and Construction Corps Hospital, Urumqi, 830002, China. 13999965869@qq.com. LA - eng PT - Journal Article DEP - 20260522 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - *Urinary Incontinence, Stress/diagnosis/etiology MH - Predictive Learning Models MH - Adult MH - Pregnancy MH - Boosting Machine Learning Algorithms MH - Random Forest MH - Logistic Models MH - Electromyography MH - Prediction Algorithms MH - *Machine Learning MH - Classification Algorithms MH - Support Vector Machine MH - Postpartum Period MH - Risk Assessment/methods MH - ROC Curve MH - *Puerperal Disorders/diagnosis MH - Risk Factors MH - *Delivery, Obstetric/adverse effects PMC - PMC13343770 OTO - NOTNLM OT - Machine learning OT - Postpartum period OT - Predictive model OT - Risk assessment OT - Stress urinary incontinence COIS- Declarations. Ethics approval and consent to participate: This study protocol was reviewed and approved by the Ethics Committee of Xinjiang Production and Construction Corps Hospital (Approval No.: 202408601). The committee confirmed that the study qualified for an exemption from full ethical review due to its retrospective nature, and consequently waived the requirement for informed consent. All procedures performed in this study were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki Declaration and its later amendments. Competing interests: The authors declare no competing interests. EDAT- 2026/05/23 06:33 MHDA- 2026/07/08 18:52 PMCR- 2026/05/22 CRDT- 2026/05/23 00:14 PHST- 2026/02/17 00:00 [received] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/07/08 18:52 [medline] PHST- 2026/05/23 06:33 [pubmed] PHST- 2026/05/23 00:14 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - 10.1186/s12884-026-09285-w [pii] AID - 9285 [pii] AID - 10.1186/s12884-026-09285-w [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 May 22;26(1):725. doi: 10.1186/s12884-026-09285-w. PMID- 42174365 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1550-9397 (Electronic) IS - 1550-9389 (Print) IS - 1550-9389 (Linking) VI - 22 IP - 1 DP - 2026 May 22 TI - Actigraphic estimates of sleep duration in those reporting sleeping less than 7 h. LID - 10.1007/s44470-026-00072-0 [doi] LID - 83 AB - OBJECTIVES: Sleep duration < 7 h increases risk for chronic disease, which makes identifying short sleep duration critical to public health. The goal of this study is to evaluate objective short sleep duration among individuals who self-report insufficient sleep to test and evaluate predictors of the subjective-objective sleep duration difference. METHODS: This study presents baseline data from a sleep extension study involving adults aged 18-65, fluency in English, and self-reported sleep duration 1 year who are homozygous for the F508del variant, targeting the underlying molecular defect. Despite evidence from clinical trials, real-world data in preschool-aged children remain limited. This study evaluated the effectiveness, safety, and tolerability of LUM-IVA in this population over 12 months of follow-up. METHODS: We conducted a multicenter, prospective study in Italy including 69 children with CF aged 1-6 years treated with LUM-IVA. Anthropometric, laboratory, microbiological, and functional parameters were collected at baseline, and after 3, 6 and 12 months. RESULTS: The median age was 3.82 years. LUM-IVA treatment was associated with significant reductions in sweat chloride concentration and pulmonary exacerbation frequency between baseline and 3/6 months. Weight improved significantly between T0 and T3 and between T1 and T2. Lung Clearance Index (LCI) also showed significant improvement between baseline and 6-12 months. Adverse events were mild and manageable; temporary treatment interruptions occurred, with no permanent discontinuations. CONCLUSION: In conclusion, in this real-world cohort of preschool children with CF homozygous for F508del, LUM-IVA therapy was associated with improvements in sweat chloride, pulmonary exacerbation frequency, and weight over 12 months, with an acceptable safety profile. These observational findings support the feasibility of early CFTR modulator therapy. IMPACT: LUM-IVA therapy in preschool children with CF shows significant real-world improvements in sweat chloride, exacerbations, weight, and LCI over 12 months, with an acceptable safety profile. It provides crucial real-world, observational data on LUM-IVA effectiveness and safety. The findings support the early use of LUM-IVA in young children with CF and potentially mitigate early progressive CF damage. CI - (c) 2026. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Presti, Santiago AU - Presti S AD - Pediatric Respiratory Unit, Department of Clinical and Experimental Medicine, San Marco Hospital, University of Catania, Catania, Italy. FAU - Cimbalo, Chiara AU - Cimbalo C AD - Cystic Fibrosis Regional Reference Centre, Department of Paediatric Medicine, Meyer Children's Hospital IRCCS, Viale Gaetano Pieraccini 24, Florence, Italy. AD - Paediatric Unit, Department of Maternal and Child Health, University of Naples Federico II, Naples, Italy. FAU - Terminiello, Alberto AU - Terminiello A AD - Pediatric Pulmonary Unit, Meyer Children's Hospital IRCCS, Florence, Italy. FAU - Fevola, Cristina AU - Fevola C AD - Cystic Fibrosis Regional Reference Centre, Department of Paediatric Medicine, Meyer Children's Hospital IRCCS, Viale Gaetano Pieraccini 24, Florence, Italy. FAU - Dacco, Valeria AU - Dacco V AD - Pediatric Department, Cystic Fibrosis Pediatric Center, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. FAU - Sepe, Angela AU - Sepe A AD - Paediatric Unit, Department of Maternal and Child Health, University of Naples Federico II, Naples, Italy. FAU - Troiani, Patrizia AU - Troiani P AD - Lazio Reference Center for Cystic Fibrosis, Hospital "Policlinico Umberto I", "Sapienza" University of Rome, Rome, Italy. FAU - Casciaro, Rosaria AU - Casciaro R AD - Cystic Fibrosis Center, IRCCS Istituto Giannina Gaslini, Genova, Italy. FAU - Di Dio, Noemi AU - Di Dio N AD - Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genoa, Genoa, Italy. FAU - Castellani, Chiara AU - Castellani C AD - Rehabilitation Unit, Meyer Children's Hospital, IRCCS, Florence, Italy. FAU - Esposito, Irene AU - Esposito I AD - Paediatric Pulmonology Unit, Regina Margherita Hospital AOU Citta della Salute e della Scienza, Torino, Italy. FAU - Ficili, Francesca AU - Ficili F AD - Cystic Fibrosis Center, Ospedale Giovanni Di Cristina, Palermo, Italy. FAU - De Venuto, Domenica AU - De Venuto D AD - Cystic Fibrosis Regional Center, Department of Biomedical and Human Oncology, Pediatrics Section, U.O. "B. Trambusti", Policlinico, University of Bari, Bari, Italy. FAU - Calderazzo, Maria Adelaide AU - Calderazzo MA AD - Cystic Fibrosis Regional Reference Center, Ospedale Giovanni Paolo II Lamezia Terme, ASP Catanzaro, Italy. FAU - Ripani, Pietro AU - Ripani P AD - Cystic Fibrosis Centre, San Liberatore Hospital, Atri, Italy. FAU - Salvatore, Donatello AU - Salvatore D AD - Cystic Fibrosis Centre, San Carlo Hospital, Potenza, Italy. FAU - Terlizzi, Vito AU - Terlizzi V AD - Cystic Fibrosis Regional Reference Centre, Department of Paediatric Medicine, Meyer Children's Hospital IRCCS, Viale Gaetano Pieraccini 24, Florence, Italy. vito.terlizzi@meyer.it. LA - eng PT - Journal Article DEP - 20260522 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Consent statement: Patients' parents provided informed consent for participation. EDAT- 2026/05/23 05:36 MHDA- 2026/05/23 05:36 CRDT- 2026/05/22 23:24 PHST- 2025/12/03 00:00 [received] PHST- 2026/04/29 00:00 [accepted] PHST- 2026/04/01 00:00 [revised] PHST- 2026/05/23 05:36 [pubmed] PHST- 2026/05/23 05:36 [medline] PHST- 2026/05/22 23:24 [entrez] AID - 10.1038/s41390-026-05121-1 [pii] AID - 10.1038/s41390-026-05121-1 [doi] PST - aheadofprint SO - Pediatr Res. 2026 May 22. doi: 10.1038/s41390-026-05121-1. PMID- 42174051 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 May 22 TI - Radiographic root pulp visibility of the mandibular left second molar as an indicator of legal adulthood (>/= 18 Years): a panoramic study. LID - 10.1038/s41598-026-53748-1 [doi] LID - 23443 AB - This study aimed to evaluate the diagnostic performance of mandibular left second molar root pulp visibility (RPV) for legal age classification (>/= 18 years) using panoramic radiographs. A total of 983 orthopantomograms (492 males, 491 females) were retrospectively analyzed. Root pulp visibility was classified according to the staging system described by Olze et al. Diagnostic performance measures, logistic regression analysis, and receiver operating characteristic (ROC) analysis were performed. A p-value < 0.05 was considered statistically significant. A statistically significant association was observed between pulp stage and legal age classification (p < 0.001). Logistic regression analysis demonstrated a stage-dependent increase in the odds of being classified as >/= 18 years, with Stage 2 and Stage 3 showing strong predictive effects (OR = 6.04 and OR = 19.13, respectively). Diagnostic performance analysis indicated that Stage >/= 2 demonstrated high specificity (0.94). ROC analysis revealed moderate discriminatory performance (AUC = 0.676; 95% CI: 0.647-0.705). Mandibular second molar root pulp visibility may serve as a useful radiographic marker for legal age threshold assessment, particularly at higher pulp stages. CI - (c) 2026. The Author(s). FAU - Akyuz, Mehmet AU - Akyuz M AD - Dentomaxillofacial Radiology Department, Faculty of Dentistry, Erzincan Binali Yildirim University, Erzincan, Turkey. mehmet.akyuz@erzincan.edu.tr. FAU - Magat, Guldane AU - Magat G AD - Dentomaxillofacial Radiology Department, Faculty of Dentistry, Necmettin Erbakan University, Konya, Turkey. gul_dent@hotmail.com. LA - eng PT - Journal Article DEP - 20260522 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Radiography, Panoramic/methods MH - *Molar/diagnostic imaging MH - Female MH - *Dental Pulp/diagnostic imaging MH - *Tooth Root/diagnostic imaging MH - *Mandible/diagnostic imaging MH - Male MH - *Age Determination by Teeth/methods MH - Adult MH - Retrospective Studies MH - Adolescent MH - Middle Aged MH - ROC Curve MH - Young Adult PMC - PMC13408855 OTO - NOTNLM OT - Age Determination by Teeth OT - Dental Pulp OT - Molar OT - Radiography, Panoramic OT - Sensitivity and Specificity COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/05/23 05:34 MHDA- 2026/07/30 12:42 PMCR- 2026/05/22 CRDT- 2026/05/22 23:20 PHST- 2026/03/06 00:00 [received] PHST- 2026/05/14 00:00 [accepted] PHST- 2026/07/30 12:42 [medline] PHST- 2026/05/23 05:34 [pubmed] PHST- 2026/05/22 23:20 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - 10.1038/s41598-026-53748-1 [pii] AID - 53748 [pii] AID - 10.1038/s41598-026-53748-1 [doi] PST - epublish SO - Sci Rep. 2026 May 22;16(1):23443. doi: 10.1038/s41598-026-53748-1. PMID- 42173662 OWN - NLM STAT- MEDLINE DCOM- 20260817 LR - 20260826 IS - 1473-0480 (Electronic) IS - 0306-3674 (Linking) VI - 60 IP - 16 DP - 2026 Aug 16 TI - Effectiveness and feasibility of home-based physical exercise interventions for children and adolescents with chronic diseases: a systematic review and meta-analysis. PG - 1259-1269 LID - 10.1136/bjsports-2025-110204 [doi] AB - OBJECTIVE: (1) To synthesise the available evidence on the clinical effectiveness of home-based physical exercise interventions in improving aerobic capacity, functional capacity, muscle strength and quality of life in children and adolescents with chronic diseases, as well as to evaluate their feasibility; and (2) to assess the reporting quality of these interventions using the Consensus on Exercise Reporting Template, with the aim of identifying gaps in methodological transparency that may limit reproducibility and scalability. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Medline (via PubMed), Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL), SportDiscus and CINAHL database (via EBSCOhost) were searched until 31 December 2025. ELIGIBILITY CRITERIA: Eligible studies included intervention designs (randomised controlled trials (RCTs), non-randomised trials and before-after studies) that evaluated home-based physical exercise interventions in children and adolescents with chronic diseases. Studies were required to include a comparator (eg, centre-based interventions, alternative home-based interventions, such as motor imagery, constraint-induced movement therapy or hand-arm bimanual intensive therapy or no intervention) or to report within-group (baseline-to-follow-up) comparisons. Outcomes of interest were aerobic capacity, functional capacity, muscle strength and quality of life. RESULTS: A total of 81 studies were included, comprising 2923 children and adolescents. The most frequently represented conditions were cerebral palsy (n=26; 32.1%), cystic fibrosis (n=10; 12.3%) and idiopathic arthritis (n=8; 9.8%). Of the 45 RCTs identified, 19 met the criteria for inclusion in the meta-analysis. Home-based physical exercise interventions were effective in increasing aerobic capacity (p<0.0001; standardised mean differences: 0.53; 95% CI 0.32 to 0.74) compared with the control group. No significant differences were observed between home-based interventions and control conditions for functional capacity or quality of life. However, functional capacity gains are similar when comparing centre-based and home-based approaches. A meta-analysis of muscle strength could not be performed due to insufficient data. Adherence to home-based physical exercise interventions was higher than 80% in 27 of the 50 studies that reported this information. Most studies reported no adverse events of home-based physical exercise interventions, with few studies reporting only mild adverse effects (eg, muscle soreness, stiffness and fatigue). CONCLUSIONS: Our meta-analysis of randomised controlled trials comparing home-based interventions with control conditions suggests that home-based physical exercise is feasible and improves aerobic capacity, but does not confer significant benefits for functional capacity, muscle strength or quality of life in children and adolescents with chronic diseases. Suboptimal reporting quality, risk of bias and inconsistent adherence/safety data necessitate cautious interpretation. PROSPERO REGISTRATION NUMBER: CRD42022330567. CI - (c) Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Sieczkowska, Sofia Mendes AU - Sieczkowska SM AUID- ORCID: 0000-0002-4869-318X AD - Applied Physiology & Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil sofiamsieczkowska@gmail.com. AD - Center of Lifestyle Medicine; Laboratory of Assessment and Conditioning in Rheumatology; Hospital das Clinicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil. AD - Federal University of Juiz de Fora, School of Physical Education and Sports, Department of Sports, Juiz de Fora, Brazil. FAU - Coimbra, Danilo Reis AU - Coimbra DR AUID- ORCID: 0000-0002-6055-0667 AD - Federal University of Juiz de Fora, School of Physical Education and Sports, Department of Sports, Juiz de Fora, Brazil. FAU - Infante Smaira, Fabiana AU - Infante Smaira F AUID- ORCID: 0000-0003-4218-4779 AD - Applied Physiology & Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil. AD - Center of Lifestyle Medicine; Laboratory of Assessment and Conditioning in Rheumatology; Hospital das Clinicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil. FAU - Mazzolani, Bruna Caruso AU - Mazzolani BC AUID- ORCID: 0000-0002-4687-3128 AD - Applied Physiology & Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil. AD - Center of Lifestyle Medicine; Laboratory of Assessment and Conditioning in Rheumatology; Hospital das Clinicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil. FAU - Paticcie, Gabriela AU - Paticcie G AUID- ORCID: 0000-0002-6189-6491 AD - Federal University of Juiz de Fora, School of Physical Education and Sports, Department of Sports, Juiz de Fora, Brazil. FAU - Astley, Camila AU - Astley C AUID- ORCID: 0000-0003-4033-2432 AD - Applied Physiology & Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil. AD - Center of Lifestyle Medicine; Laboratory of Assessment and Conditioning in Rheumatology; Hospital das Clinicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil. FAU - Iraha, Amanda AU - Iraha A AD - Applied Physiology & Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil. AD - Center of Lifestyle Medicine; Laboratory of Assessment and Conditioning in Rheumatology; Hospital das Clinicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil. FAU - Roschel, Hamilton AU - Roschel H AUID- ORCID: 0000-0002-9513-6132 AD - Applied Physiology & Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil. AD - Center of Lifestyle Medicine; Laboratory of Assessment and Conditioning in Rheumatology; Hospital das Clinicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil. FAU - Pecanha, Tiago AU - Pecanha T AUID- ORCID: 0000-0003-4968-5525 AD - Manchester Metropolitan University, Institute of Sport, Manchester, UK. FAU - Gualano, Bruno AU - Gualano B AUID- ORCID: 0000-0001-7100-8681 AD - Applied Physiology & Nutrition Research Group - School of Physical Education and Sport and Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil. AD - Center of Lifestyle Medicine; Laboratory of Assessment and Conditioning in Rheumatology; Hospital das Clinicas HCFMUSP, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260816 PL - England TA - Br J Sports Med JT - British journal of sports medicine JID - 0432520 SB - IM MH - Humans MH - Child MH - Adolescent MH - Chronic Disease/therapy MH - *Exercise Therapy/methods MH - Quality of Life MH - Muscle Strength MH - Feasibility Studies MH - *Home Care Services MH - Exercise Tolerance OTO - NOTNLM OT - Child Health OT - Exercise Therapy OT - Meta-analysis OT - Systematic review COIS- Competing interests: None declared. EDAT- 2026/05/23 05:35 MHDA- 2026/08/17 23:39 CRDT- 2026/05/22 21:12 PHST- 2026/05/08 00:00 [accepted] PHST- 2026/08/17 23:39 [medline] PHST- 2026/05/23 05:35 [pubmed] PHST- 2026/05/22 21:12 [entrez] AID - bjsports-2025-110204 [pii] AID - 10.1136/bjsports-2025-110204 [doi] PST - epublish SO - Br J Sports Med. 2026 Aug 16;60(16):1259-1269. doi: 10.1136/bjsports-2025-110204. PMID- 42172880 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 1879-1271 (Electronic) IS - 0268-0033 (Print) IS - 0268-0033 (Linking) VI - 137 DP - 2026 Jul TI - Automated gait classification: Comparison of automated algorithms to expert classification. PG - 106864 LID - S0268-0033(26)00119-1 [pii] LID - 10.1016/j.clinbiomech.2026.106864 [doi] AB - BACKGROUND: Accurate classification of gait patterns in children with cerebral palsy (CP) is critical for guiding treatment but requires expert interpretation of data. Automated methods have potential to improve consistency and scalability; however, clinically meaningful automated tools are limited. This work aimed to determine if automated algorithms based on established gait classifications can reproduce expert clinical classification in children with CP. METHODS: An automated MATLAB algorithm was developed to assign gait classifications using two established systems (Rodda & Graham and Rozumalski & Schwartz). A sample of children with CP who met criteria for crouch gait underwent automated classification. Three expert gait analysts independently classified all trials using standardized definitions corresponding to each system. Fleiss's kappa quantified inter-rater reliability, while Cohen's kappa, weighted kappa, percent agreement, and macro F1 scores quantified agreement between each reviewer and the automated classifications. FINDINGS: Inter-rater reliability among reviewers was substantial for Rodda & Graham (kappa = 0.753), with high agreement between reviewers. Inter-rater reliability among reviewers was moderate for Rozumalski & Schwartz (kappa = 0.456) and agreement between raters was lower and more variable, with some classifications demonstrating full disagreement among reviewers. INTERPRETATION: Automated gait classification based on quantitative gait criteria can achieve agreement with gait analysis experts for systems with clear biomechanical boundaries. More complex cluster-based systems yield lower agreement, reflecting inherent ambiguity in cluster overlap. These findings support use of automated tools as reliable, objective ground-truth for large-scale analyses and for training markerless or video-based assessment algorithms aimed at expanding gait evaluation beyond specialized motion laboratories. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Kruger, Karen M AU - Kruger KM AD - Shriners Children's Chicago, 2211 N. Oak Park Ave., Chicago, IL 60707, USA; Orthopedic and Rehabilitation Engineering Center, Marquette University & Medical College of Wisconsin, 1250 W. Wisconsin Ave., Milwaukee, WI 53233, USA. Electronic address: karen.kruger@marquette.edu. FAU - Krzak, Joseph J AU - Krzak JJ AD - Shriners Children's Chicago, 2211 N. Oak Park Ave., Chicago, IL 60707, USA; Midwestern University, Physical Therapy Program, 555 31(st) St., Downers Grove, IL 60515, USA. FAU - Chafetz, Ross S AU - Chafetz RS AD - Shiners Children's Philadelphia, 3551 N Broad St, Philadelphia, PA 19140, USA. FAU - Sienko, Susan AU - Sienko S AD - Shriners Children's Portland, 3101 SW Sam Jackson Park Rd, Portland, OR 97239, USA. FAU - Bauer, Jeremy P AU - Bauer JP AD - Shriners Children's Portland, 3101 SW Sam Jackson Park Rd, Portland, OR 97239, USA. LA - eng GR - R01 HD118205/HD/NICHD NIH HHS/United States PT - Comparative Study PT - Journal Article DEP - 20260509 PL - England TA - Clin Biomech (Bristol) JT - Clinical biomechanics (Bristol, Avon) JID - 8611877 SB - IM MH - Child MH - Female MH - Humans MH - Male MH - Automation MH - Biomechanical Phenomena MH - *Cerebral Palsy/physiopathology MH - *Classification Algorithms MH - *Gait Analysis/methods MH - *Gait Disorders, Neurologic/physiopathology MH - Observer Variation MH - *Pattern Recognition, Automated/methods MH - Reproducibility of Results PMC - PMC13288829 MID - NIHMS2178823 OTO - NOTNLM OT - Automated classification OT - Cerebral palsy OT - Clinical decision support OT - Gait analysis OT - Motion analysis COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Karen Kruger reports financial support was provided by National Institutes of Health. Karen Kruger reports financial support was provided by Shriners Children's. Joseph Krzak reports financial support was provided by Shriners Children's. Susan Sienko reports financial support was provided by Shriners Children's. Jeremy Bauer reports financial support was provided by Shriners Children's. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/23 05:35 MHDA- 2026/06/12 13:01 PMCR- 2026/06/23 CRDT- 2026/05/22 18:05 PHST- 2026/01/05 00:00 [received] PHST- 2026/04/21 00:00 [revised] PHST- 2026/04/29 00:00 [accepted] PHST- 2026/06/12 13:01 [medline] PHST- 2026/05/23 05:35 [pubmed] PHST- 2026/05/22 18:05 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - S0268-0033(26)00119-1 [pii] AID - 10.1016/j.clinbiomech.2026.106864 [doi] PST - ppublish SO - Clin Biomech (Bristol). 2026 Jul;137:106864. doi: 10.1016/j.clinbiomech.2026.106864. Epub 2026 May 9. PMID- 42172710 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260611 IS - 1090-2414 (Electronic) IS - 0147-6513 (Linking) VI - 319 DP - 2026 Jul 1 TI - Ecotoxicological insights into fluoride pollution affecting soil, plant and human health. PG - 120295 LID - S0147-6513(26)00624-X [pii] LID - 10.1016/j.ecoenv.2026.120295 [doi] AB - Fluoride contamination impacts the water-soil-plant continuum, with consequences for soil functions, crop performance, and dietary exposure. Although fluoride occurrence data are extensive, interpretation and cross-study comparability remain constrained by inconsistent reporting of total fluoride versus fluoride fractions up taken in edible plant parts, limited co-measurement across matched water-soil-plant compartments, and a shortage of long-term field evaluations of mitigation impacts on soil fertility and ecosystem services. To address these limitations, we (i) consolidate dominant sources and transfer pathways linking groundwater, soils, crops, and food webs; (ii) summarize the geochemical and soil controls governing the fluoride mobility and uptake, including pH/alkalinity, major-ion chemistry, Ca/Al/Fe-mediated complexation and precipitation, and sorption to clays and metal (hydr)oxides; (iii) integrate ecotoxicological evidence for soil processes and crop-relevant physiological endpoints; and (iv) critically assess the remediation and management options. Across the literature, a central finding is that risk is governed less by total soil fluoride inventories than by the fluoride concentrations up-taken in edible plant parts, which increases under alkaline conditions and in bicarbonate-, and sodium-rich systems and can be sustained through chronic irrigation loading. Evidences indicate that elevated fluoride suppresses microbial activity and enzyme functions essential for nutrient cycling, disrupts Ca-P homeostasis, reduces photosynthetic capacity in sensitive crops, and transfers to edible tissues and beverages, thereby increasing dietary exposure, including in vulnerable populations such as children. Hotspot assessments require explicit consideration of co-contaminant stressors and confounding geochemical conditions. We conclude that effective management should emphasize source control, mechanism-based immobilization (e.g., Ca-based amendments and targeted sorbents), and integrated approaches validated through multi-season field trials. Future priorities include standardized fraction metrics, matched compartment monitoring, crop dose-response datasets, and evaluation of remediation durability, agronomic trade-offs, and cost-effectiveness. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Farooqi, Zia Ur Rahman AU - Farooqi ZUR AD - Yunnan Provincial Key Lab of Soil Carbon Sequestration and Pollution Control, Faculty of Environmental Science and Engineering, Kunming University of Science and Technology, Kunming 650500, China; Yunnan International Joint Laboratory for Emission Reduction and Carbon Sequestration in Agricultural Soils, Kunming 650500, China. FAU - Karim, Abdul AU - Karim A AD - Institute of Soil and Environmental Sciences, University of Agriculture Faisalabad, 38040, Pakistan. FAU - Qadir, Ayesha Abdul AU - Qadir AA AD - School of Earth System Science, Tianjin University, Tianjin 300072, China. FAU - Sonia, Ayesha AU - Sonia A AD - School of Earth System Science, Tianjin University, Tianjin 300072, China. FAU - Mohy-Ud-Din, Waqas AU - Mohy-Ud-Din W AD - School of Earth System Science, Tianjin University, Tianjin 300072, China. FAU - Wambu, Enos Wamalwa AU - Wambu EW AD - Department of Chemistry and Biochemistry, University of Eldoret, P.O. Box 1125, Eldoret 30100, Kenya. FAU - Ali, Qasim AU - Ali Q AD - Department of Soil Science, Faculty of Agriculture and Environment, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan. FAU - Haider, Fasih Ullah AU - Haider FU AD - State Key Laboratory of Black Soils Conservation and Utilization, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun, China. FAU - Gururani, Mayank Anand AU - Gururani MA AD - Department of Biology, College of Science, United Arab Emirates University, Al Ain, United Arab Emirates. Electronic address: gururani@uaeu.ac.ae. FAU - Zulfiqar, Usman AU - Zulfiqar U AD - Department of Agronomy, Faculty of Agriculture and Environment, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan; Department of Biology, Nakhchivan State University, Nakhchivan, Azerbaijan. Electronic address: usman.zulfiqar@iub.edu.pk. LA - eng PT - Journal Article PT - Review DEP - 20260522 PL - Netherlands TA - Ecotoxicol Environ Saf JT - Ecotoxicology and environmental safety JID - 7805381 RN - Q80VPU408O (Fluorides) RN - 0 (Soil Pollutants) RN - 0 (Soil) SB - IM MH - *Fluorides/toxicity/analysis MH - *Soil Pollutants/toxicity/analysis MH - Humans MH - *Soil/chemistry MH - Ecotoxicology MH - *Plants/drug effects MH - Crops, Agricultural/drug effects MH - Environmental Monitoring MH - Food Chain OTO - NOTNLM OT - Agriculture OT - Apatite OT - Fluoride pollution OT - Fluorite OT - Human health OT - Pesticides COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/22 19:21 MHDA- 2026/06/11 18:36 CRDT- 2026/05/22 17:59 PHST- 2026/01/29 00:00 [received] PHST- 2026/05/16 00:00 [revised] PHST- 2026/05/19 00:00 [accepted] PHST- 2026/06/11 18:36 [medline] PHST- 2026/05/22 19:21 [pubmed] PHST- 2026/05/22 17:59 [entrez] AID - S0147-6513(26)00624-X [pii] AID - 10.1016/j.ecoenv.2026.120295 [doi] PST - ppublish SO - Ecotoxicol Environ Saf. 2026 Jul 1;319:120295. doi: 10.1016/j.ecoenv.2026.120295. Epub 2026 May 22. PMID- 42172607 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260522 LR - 20260813 IS - 1929-073X (Print) IS - 1929-073X (Electronic) IS - 1929-073X (Linking) VI - 15 DP - 2026 May 22 TI - Pulse Discovery Toolkit, a Multicomponent Nutrition Intervention for Preschool Children in Childcare Centers: Mixed Methods Pilot Study. PG - e55866 LID - 10.2196/55866 [doi] LID - e55866 AB - BACKGROUND: Children's eating habits are formed at an early age, making childhood a crucial period for introducing novel foods, such as pulse-based food products. Pulse Discovery Toolkit (PDTK) intervention was designed to increase familiarity with pulses and to eventually contribute to the consumption of pulse-based foods among preschool children in childcare centers (CCs). OBJECTIVE: To determine PDTK's impact on knowledge, acceptability, and consumption of pulse-based foods among preschool children attending CCs, and to assess its feasibility and acceptability by early childhood educators (ECE) and cooks. The nutrient contents and food group servings of pulse-based intervention recipes in the PDTK were also compared with regular CC recipes. METHODS: The PDTK intervention was delivered over a 3-month period in 2 CCs in Saskatoon (50 children, 8 staff). The intervention, which integrated taste exposure and nutrition education, consisted of 12 child-friendly weekly lessons, a food service guide for cooks, 15 recipes for pulse-based foods, 4 intervention recipes incorporated in the CC menu, and 4 parent newsletters. Mixed methods were used with pre- and postintervention knowledge tests, plate waste measurement, sensory evaluation, ECE and cook's perspective, and nutrient content comparison of the intervention and control foods from the regular childcare menu to evaluate the intervention's impact. Improvements in correct identification of chickpeas (2/21 [10%] at preintervention to 7/21 [33%] at postintervention, P=.074), beans (8/21 [38%] to 11/21 [52%], P=.68), and peas (6/21 [27%] to 8/21 [38%], P=.61) were not statistically significant. Children consumed higher amounts of the regular recipes (293.54, SD 27.65; 178.46, SD 24.33) than the intervention recipes (211.56, SD 25.61; 108.83, SD 21.97) at both times, respectively. However, at the end of the intervention, significant differences were only observed in the amount of total food consumption (P=.049) and the protein content (P=.04) when consumption proportion was examined, with both being higher for the control recipes in comparison to the intervention recipes. The majority (92% and 72%) of the children rated the refried bean wrap and lentil smoothie, "yummy," respectively. Most of the intervention recipes have lower energy, fat, and sodium content compared with the regular CC recipes. Findings from ECE semistructured interviews and the lesson plan evaluations revealed that the ECEs reacted favorably to the curriculum. The cooks from the participating CCs did not report any barriers to cooking pulses in their facility. However, the need for modification to make the recipes easier to cook in CCs was noted in our study. CONCLUSIONS: With a few modifications to make some of the lessons more age-appropriate and some of the recipes easier to cook, it is feasible to implement the PDTK in CCs in order to promote regular consumption of pulses. CI - (c) Hiwot Abebe Haileslassie, Renee Ramikie, Hassan Vatanparast, D Dan Ramdath, Amanda Froehlich Chow, Phyllis Shand, Rachel Engler-Stringer, Jessica R L Lieffers, Shannon Hood-Niefer, Carol Henry. Originally published in the Interactive Journal of Medical Research (https://www.i-jmr.org/). FAU - Haileslassie, Hiwot Abebe AU - Haileslassie HA AUID- ORCID: 0000-0002-1975-1811 AD - College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada. AD - Agricultural, Food and Nutritional Science, University of Alberta, 8602-112 St, Edmonton, AB, T6G 2E1, Canada, 1 780 492 7742. FAU - Ramikie, Renee AU - Ramikie R AUID- ORCID: 0000-0001-5479-5281 AD - College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada. FAU - Vatanparast, Hassan AU - Vatanparast H AUID- ORCID: 0000-0003-2621-8385 AD - College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada. AD - School of Public Health, University of Saskatchewan, Saskatoon, Saskatoon, SK, Canada. FAU - Ramdath, D Dan AU - Ramdath DD AUID- ORCID: 0000-0002-7368-3127 AD - College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada. FAU - Froehlich Chow, Amanda AU - Froehlich Chow A AUID- ORCID: 0000-0002-7576-0237 AD - School of Public Health, University of Saskatchewan, Saskatoon, Saskatoon, SK, Canada. FAU - Shand, Phyllis AU - Shand P AUID- ORCID: 0000-0003-2985-5670 AD - College of Agriculture and Bioresources, University of Saskatchewan, Saskatoon, SK, Canada. FAU - Engler-Stringer, Rachel AU - Engler-Stringer R AUID- ORCID: 0000-0003-1976-1339 AD - Department of Community Health and Epidemiology, University of Saskatchewan, Saskatoon, SK, Canada. FAU - Lieffers, Jessica R L AU - Lieffers JRL AUID- ORCID: 0000-0003-4380-1011 AD - College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada. FAU - Hood-Niefer, Shannon AU - Hood-Niefer S AUID- ORCID: 0000-0002-0707-2512 AD - Saskatchewan Food Industry Development Centre Inc, Saskatoon, SK, Canada. FAU - Henry, Carol AU - Henry C AUID- ORCID: 0000-0002-5982-2936 AD - College of Pharmacy and Nutrition, University of Saskatchewan, Saskatoon, SK, Canada. LA - eng PT - Journal Article DEP - 20260522 PL - Canada TA - Interact J Med Res JT - Interactive journal of medical research JID - 101598421 PMC - PMC13197110 OTO - NOTNLM OT - child OT - childcare center OT - children OT - dietary OT - nutrition OT - nutrition intervention OT - nutritional OT - pediatric OT - preschool children OT - pulse OT - sensory evaluation COIS- Conflicts of Interest: None declared. EDAT- 2026/05/22 19:21 MHDA- 2026/05/22 19:22 PMCR- 2026/05/22 CRDT- 2026/05/22 16:52 PHST- 2023/12/27 00:00 [received] PHST- 2026/03/29 00:00 [revised] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/05/22 19:22 [medline] PHST- 2026/05/22 19:21 [pubmed] PHST- 2026/05/22 16:52 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - v15i1e55866 [pii] AID - 55866 [pii] AID - 10.2196/55866 [doi] PST - epublish SO - Interact J Med Res. 2026 May 22;15:e55866. doi: 10.2196/55866. PMID- 42172263 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 5 DP - 2026 TI - Association between different atherogenic and insulin resistance indices and infertility in polycystic ovary syndrome patients. PG - e0343783 LID - 10.1371/journal.pone.0343783 [doi] LID - e0343783 AB - BACKGROUND: This study aimed to assess the association between multiple atherogenic and insulin resistance indices-including TyG, TyG-BMI, AIP, TG-HDL, and METS-IR-and infertility in women with PCOS, and to evaluate their clinical utility. METHODS: In this cross-sectional study, we analyzed data from 669 sexually active women aged 18-45 with PCOS treated at a tertiary center in Iran (2021-2023). We compared infertile women with PCOS (>/=12 months unsuccessful conception, n = 274) to fertile women with PCOS (n = 395). Logistic regression, restricted cubic spline, and receiver operating characteristic (ROC) analysis were used to assess associations and predictive performance. RESULTS: Infertile women had significantly worse metabolic profiles across all indices (P < 0.001). AIP showed the largest point estimate of association (adjusted OR = 9.065, 95% CI: 1.722-47.721). TG-HDL showed a significant non-linear relationship, with ORs rising steeply up to a ratio of ~2.5. Predictive ability was modest, with AUCs ranging from 0.598 (TyG-BMI) to 0.625 (AIP, TG-HDL). CONCLUSION: Several metabolic indices, particularly AIP, are associated with infertility in women with PCOS, though their standalone predictive utility remains limited. CI - Copyright: (c) 2026 Jafari et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Jafari, Kasra AU - Jafari K AD - Research Development Center, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran. AD - Department of Epidemiology, School of Health, Iran University of Medical Sciences, Tehran, Iran. FAU - Azmi-Naei, Nazanin AU - Azmi-Naei N AD - Department of Epidemiology, School of Public Health, Shahroud University of Medical Sciences, Shahroud, Iran. FAU - Tajik, Nooshan AU - Tajik N AD - Department of Obstetrics and Gynecology, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran. FAU - Moini, Ashraf AU - Moini A AD - Department of Obstetrics and Gynecology, Endocrinology and Female Infertility Unit, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran. AD - Breast Disease Research Center (BDRC), Tehran University Of Medical Sciences, Tehran, Iran. AD - Department of Endocrinology and Female Infertility, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. FAU - Abiri, Amene AU - Abiri A AUID- ORCID: 0000-0002-0207-5677 AD - Department of Obstetrics and Gynecology, School of Medicine, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article DEP - 20260522 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/complications/metabolism MH - *Insulin Resistance MH - Adult MH - Cross-Sectional Studies MH - *Infertility, Female/metabolism/etiology MH - *Atherosclerosis/complications/metabolism MH - Young Adult MH - Adolescent MH - Middle Aged MH - ROC Curve MH - Body Mass Index MH - Iran/epidemiology PMC - PMC13196974 COIS- The authors have declared that no competing interests exist. EDAT- 2026/05/22 19:21 MHDA- 2026/05/22 19:22 PMCR- 2026/05/22 CRDT- 2026/05/22 13:44 PHST- 2025/10/16 00:00 [received] PHST- 2026/02/10 00:00 [accepted] PHST- 2026/05/22 19:22 [medline] PHST- 2026/05/22 19:21 [pubmed] PHST- 2026/05/22 13:44 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - PONE-D-25-55841 [pii] AID - 10.1371/journal.pone.0343783 [doi] PST - epublish SO - PLoS One. 2026 May 22;21(5):e0343783. doi: 10.1371/journal.pone.0343783. eCollection 2026. PMID- 42172186 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261021 IS - 1748-3115 (Electronic) IS - 1748-3107 (Linking) VI - 21 IP - 7 DP - 2026 Oct TI - Design and feasibility implementation of an interactive learning room for children with down syndrome to promote inclusive educational access in Indonesia. PG - 3795-3811 LID - 10.1080/17483107.2026.2674282 [doi] AB - OBJECTIVE: This study aims to design and evaluate the feasibility of an interactive multisensory learning room to support engagement and school readiness among children with Down syndrome (DS) and autism spectrum disorder (ASD) in Indonesia. METHODS: A qualitative observational design was employed involving 10 participants aged 3-15 years. The system integrates four interactive components: mimic stimulation, motor coordination, colour recognition, and auditory feedback. Participants engaged in supervised sessions lasting 30-45 minutes. Behavioural responses were assessed using a four-point Likert-type observational scale and supported by semi-structured interviews with parents, caregivers, therapists, and a primary school teacher. Since 2022, the system has been implemented twice weekly with rotating small groups, with additional observations conducted between January 2023 and June 2025. RESULTS: Findings indicate that the motor coordination component significantly increased physical activity and engagement. The music and video components contributed to emotional comfort and improved willingness to participate. Sustained observations suggest consistent engagement patterns over time, supporting the system's usability and adaptability in real-world settings. CONCLUSION: The study demonstrates the feasibility and sustainability of implementing an affordable multisensory learning environment in under-resourced contexts. The findings provide a foundation for future controlled and outcome-based studies and contribute to broader efforts toward inclusive education aligned with Sustainable Development Goals (SDGs) 4, 9, 10, and 17. FAU - Hedwig, Rinda AU - Hedwig R AD - Department of Computer Engineering, Faculty of Engineering, Bina Nusantara University, Jakarta, Indonesia. FAU - Alfianto, Ade Septian AU - Alfianto AS AD - Ukrida Science Center, Krida Wacana Christian University, Jakarta, Indonesia. FAU - Purnama, Louis Putra AU - Purnama LP AD - Ukrida Science Center, Krida Wacana Christian University, Jakarta, Indonesia. FAU - Tanra, Ivan AU - Tanra I AD - Department of Electrical Engineering, Faculty of Smart Technology, Krida Wacana Christian University, Jakarta, Indonesia. FAU - Rombot, Olifia AU - Rombot O AD - Department of Primary Teacher Education, Faculty of Humanity, Bina Nusantara University, Jakarta, Indonesia. FAU - Linggarjati, Jimmy AU - Linggarjati J AD - Department of Computer Engineering, Faculty of Engineering, Bina Nusantara University, Jakarta, Indonesia. FAU - Sondhi, Savita AU - Sondhi S AD - Bina Nusantara Group, Jakarta, Indonesia. FAU - Kosasih, Wibowo AU - Kosasih W AD - Bina Nusantara Group, Jakarta, Indonesia. FAU - Tanuwijaya, Evan AU - Tanuwijaya E AD - PT Jendela Lentera Dunia, Bogor, Indonesia. FAU - Sutjiawan, Kenneth AU - Sutjiawan K AD - Department of Computer Engineering, Faculty of Engineering, Bina Nusantara University, Jakarta, Indonesia. FAU - Susanto, Rudy AU - Susanto R AD - Department of Computer Engineering, Faculty of Engineering, Bina Nusantara University, Jakarta, Indonesia. FAU - Saputra, Marcel AU - Saputra M AD - Business Engineering Department, BINUS ASO School of Engineering, Bina Nusantara University, Tangerang, Indonesia. FAU - Wishnoebroto, Wishnoebroto AU - Wishnoebroto W AD - School of Computer Science, Bina Nusantara University, Jakarta, Indonesia. LA - eng PT - Journal Article PT - Observational Study DEP - 20260522 PL - England TA - Disabil Rehabil Assist Technol JT - Disability and rehabilitation. Assistive technology JID - 101255937 SB - IM MH - Humans MH - Child MH - Indonesia MH - *Down Syndrome/rehabilitation MH - Child, Preschool MH - Feasibility Studies MH - Male MH - Adolescent MH - Female MH - *Autism Spectrum Disorder/rehabilitation MH - Qualitative Research MH - *Mainstreaming, Education OAB - Children with disabilities, particularly those with Down syndrome (DS), often face significant barriers to accessing formal education in developing countries.Due to the limited availability of specialised educational facilities, many parents choose to keep their children with disabilities at home, resulting in reduced opportunities for learning and social development.Although the government has introduced initiatives to enhance accessibility and inclusivity in public services for individuals with disabilities, such programmes remain limited in reach, especially in rural and remote regions of Indonesia.Implementing interactive learning rooms for children with DS has the potential to support the development of essential skills, including motor coordination, speech, auditory processing, memory and cognitive recognition. OABL- eng OTO - NOTNLM OT - Children with disabilities OT - Sustainable Development goal OT - affordable technology OT - down syndrome OT - interactive learning room EDAT- 2026/05/22 19:21 MHDA- 2026/10/19 17:31 CRDT- 2026/05/22 13:23 PHST- 2026/10/19 17:31 [medline] PHST- 2026/05/22 19:21 [pubmed] PHST- 2026/05/22 13:23 [entrez] AID - 10.1080/17483107.2026.2674282 [doi] PST - ppublish SO - Disabil Rehabil Assist Technol. 2026 Oct;21(7):3795-3811. doi: 10.1080/17483107.2026.2674282. Epub 2026 May 22. PMID- 42172083 OWN - NLM STAT- MEDLINE DCOM- 20260702 LR - 20260813 IS - 1365-2788 (Electronic) IS - 0964-2633 (Print) IS - 0964-2633 (Linking) VI - 70 IP - 8 DP - 2026 Aug TI - Design and Development of 'Building Opportunities for Optimal physical activity Skills Training in children with Down Syndrome (BOOST-DS)' Programme and its Content Validation through Consensus using Modified Delphi method. PG - 811-822 LID - 10.1111/jir.70119 [doi] AB - BACKGROUND: Children with Down syndrome (DS) often do not meet daily physical activity requirements, which affects their participation in daily activities and overall quality of life. Structured physical activity programmes could address these issues, but accessible, participation-based activities are limited. METHOD: The Building Opportunities for Optimal physical activity Skills Training in children with Down Syndrome (BOOST-DS) programme was designed, developed and content validated in three phases. A conceptual framework was developed from the relevant literature, followed by the identification physical activity components through brainstorming and discussions. The final content validation phase involved expert consensus using a modified Delphi method. RESULTS: The BOOST-DS identified 62 active play items across six domains of physical activity. After three Delphi rounds, 53 items achieved expert agreement. CONCLUSION: The content-validated BOOST-DS programme includes 53 play-based activities across six physical activity domains to enhance participation outcomes in children with DS. TRIAL REGISTRATION: The study was registered in the Clinical Trial Registry of India: CTRI/2023/08/056291 on 5 August 2023. CI - (c) 2026 The Author(s). Journal of Intellectual Disability Research published by MENCAP and John Wiley & Sons Ltd. FAU - Megha Jain, V AU - Megha Jain V AD - Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka, India. FAU - Rao, Bhamini K AU - Rao BK AUID- ORCID: 0000-0002-2708-0245 AD - Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka, India. FAU - Ramachandran, Selvam AU - Ramachandran S AUID- ORCID: 0000-0001-7227-9547 AD - Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka, India. CN - Delphi Expert Panel LA - eng PT - Journal Article DEP - 20260522 PL - England TA - J Intellect Disabil Res JT - Journal of intellectual disability research : JIDR JID - 9206090 SB - IM MH - Humans MH - *Down Syndrome/rehabilitation MH - Delphi Technique MH - Child MH - *Exercise Therapy/methods/standards MH - Consensus MH - *Exercise MH - *Program Development/standards MH - Female MH - Male PMC - PMC13327175 OTO - NOTNLM OT - agility OT - balance OT - children with Down syndrome OT - coordination OT - endurance OT - exercise programme OT - flexibility OT - physical activity participation OT - strength COIS- The authors declare no conflicts of interest. FIR - Expert Panel, Delphi IR - Expert Panel D FIR - Kanna, B S Santhosh IR - Kanna BSS FIR - Poojari, Deepalaxmi Paresh IR - Poojari DP FIR - Metgud, Deepa IR - Metgud D FIR - Joshi, Kirti IR - Joshi K FIR - Vijaykumar, Mithula IR - Vijaykumar M FIR - Attal, Radhika IR - Attal R FIR - Alva, Rajitha IR - Alva R FIR - Parmar, Sanjay Tejraj IR - Parmar ST FIR - Karnad, Shreekanth D IR - Karnad SD FIR - Joseph, Smitha Elizabeth IR - Joseph SE FIR - Mohanty, Tanochni IR - Mohanty T EDAT- 2026/05/22 19:21 MHDA- 2026/07/02 18:32 PMCR- 2026/07/02 CRDT- 2026/05/22 12:12 PHST- 2026/04/01 00:00 [revised] PHST- 2024/10/29 00:00 [received] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/07/02 18:32 [medline] PHST- 2026/05/22 19:21 [pubmed] PHST- 2026/05/22 12:12 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - JIR70119 [pii] AID - 10.1111/jir.70119 [doi] PST - ppublish SO - J Intellect Disabil Res. 2026 Aug;70(8):811-822. doi: 10.1111/jir.70119. Epub 2026 May 22. PMID- 42172045 OWN - NLM STAT- MEDLINE DCOM- 20260731 LR - 20260821 IS - 1365-2672 (Electronic) IS - 1364-5072 (Linking) VI - 137 IP - 6 DP - 2026 Jun 3 TI - Development of a synbiotic potential score as a quantitative approach for selecting putative synergistic strain-prebiotic candidates. LID - lxag124 [pii] LID - 10.1093/jambio/lxag124 [doi] AB - AIMS: Synbiotics are increasingly being examined for their potential to enhance host health. Synergistic synbiotics are specifically designed such that the prebiotic component is selectively utilized by co-administered microorganisms, thereby providing enhanced benefits to the host. In this study, we propose a synbiotic potential score (SPS), a quantitative, high-throughput method for assessing bacterial proliferation on selected dietary fibres that incorporates growth curve values. This score was applied to both rich and minimal media to assess the utilization of difficult-to-digest fibres, such as resistant maltodextrin (RM). METHODS AND RESULTS: The SPS score was first calculated for eight putative probiotic strains grown on short chain fructooligosaccharides (scFOS), RM, and their combination. Lactiplantibacillus plantarum DSM 20205, Bifidobacterium breve JCM 7017, Bifidobacterium longum APC 1472, Bifidobacterium adolescentis DSM 20083, and Bifidobacterium animalis subsp. lactis ATCC 27536 scored highest for scFOS, whereas their growth on RM compared to that on media without carbohydrates was minimal. Four strains were selected for further experiments in minimal MRS medium. All four bacteria demonstrated improved utilization of RM, as indicated by a higher SPS score, suggesting that minimal media better supports the specific utilization of target prebiotics. CONCLUSIONS: Our approach reduces confounding factors, enabling clearer insights into prebiotic-probiotic interactions. This supports the systematic selection of effective strain-prebiotic pairs, guiding targeted synbiotic development for personalized nutrition and improved health outcomes. Future studies should validate our approach across multiple strains within the same species and using in vivo models. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Applied Microbiology International. FAU - Wasiewska, Luiza A AU - Wasiewska LA AD - APC Microbiome Ireland, University College Cork, Cork T12 YT20, Ireland. FAU - Kareem, Lamiah AU - Kareem L AD - APC Microbiome Ireland, University College Cork, Cork T12 YT20, Ireland. FAU - Linares, Ainhoa G AU - Linares AG AD - APC Microbiome Ireland, University College Cork, Cork T12 YT20, Ireland. FAU - Gunnigle, Eoin AU - Gunnigle E AD - APC Microbiome Ireland, University College Cork, Cork T12 YT20, Ireland. FAU - Risso, Davide AU - Risso D AD - Tate & Lyle, PLC, 5 Marble Arch, London W1H 7EJ, United Kingdom. FAU - Laurie, Ieva AU - Laurie I AD - Tate & Lyle, PLC, 5 Marble Arch, London W1H 7EJ, United Kingdom. FAU - van Sinderen, Douwe AU - van Sinderen D AUID- ORCID: 0000-0003-1823-7957 AD - APC Microbiome Ireland, University College Cork, Cork T12 YT20, Ireland. AD - School of Microbiology, University College Cork, Cork T12 YT20, Ireland. FAU - Clarke, Gerard AU - Clarke G AD - APC Microbiome Ireland, University College Cork, Cork T12 YT20, Ireland. AD - Department of Psychiatry and Neurobehavioural Science, University College Cork, Cork T12 YT20, Ireland. FAU - Schellekens, Harriet AU - Schellekens H AD - APC Microbiome Ireland, University College Cork, Cork T12 YT20, Ireland. AD - Department of Anatomy and Neuroscience, University College Cork, Cork T12 XF62, Ireland. LA - eng GR - 12/RC/2273_P2/Research Ireland in the form of a Research Centre/ GR - APC Microbiome Ireland/ PT - Journal Article PL - England TA - J Appl Microbiol JT - Journal of applied microbiology JID - 9706280 RN - 0 (Prebiotics) RN - 0 (Culture Media) RN - 0 (fructooligosaccharide) RN - 0 (Oligosaccharides) SB - IM EIN - J Appl Microbiol. 2026 Aug 4;137(8):lxag196. doi: 10.1093/jambio/lxag196. PMID: 42627682 MH - *Synbiotics/analysis MH - *Prebiotics/analysis MH - Bifidobacterium/growth & development/metabolism MH - Lactiplantibacillus plantarum/growth & development/metabolism MH - Culture Media MH - Oligosaccharides/metabolism OTO - NOTNLM OT - Bifidobacterium OT - Fibres OT - Microbiota OT - Synbiotic potential score (SPS) OT - Synergistic synbiotics EDAT- 2026/05/22 12:34 MHDA- 2026/06/06 06:35 CRDT- 2026/05/22 11:42 PHST- 2025/12/19 00:00 [received] PHST- 2026/03/21 00:00 [revised] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/06/06 06:35 [medline] PHST- 2026/05/22 12:34 [pubmed] PHST- 2026/05/22 11:42 [entrez] AID - 8690710 [pii] AID - 10.1093/jambio/lxag124 [doi] PST - ppublish SO - J Appl Microbiol. 2026 Jun 3;137(6):lxag124. doi: 10.1093/jambio/lxag124. PMID- 42172017 OWN - NLM STAT- Publisher LR - 20260522 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) DP - 2026 May 22 TI - From selective eating to rigid healthy eating: Childhood picky eating, perfectionism, and orthorexic tendencies in adulthood. PG - 2601060261454264 LID - 10.1177/02601060261454264 [doi] AB - Background: Orthorexic tendencies involve rigid, rule-governed "healthy eating" and are associated with perfectionism, yet their developmental correlates are less understood. Aim: This study examined whether retrospectively reported childhood picky eating is associated with orthorexic tendencies in adulthood, whether maladaptive perfectionism dimensions mediate these associations, and whether associations vary by gender. Methods: Adults (N = 209) completed validated self-report measures of childhood picky eating, orthorexic tendencies (Eating Habits Questionnaire), and multidimensional perfectionism. Correlations, bootstrapped mediation models (2000 resamples), and gender-moderation analyses were conducted, controlling for age and gender. Results: Childhood picky eating was modestly associated with orthorexic tendencies (r = .18, p = .009). Indirect effects were statistically significant via doubts about actions (beta = .06, 95% CI [.02, .10]) and parental expectations/criticism (beta = .05, 95% CI [.01, .10]). The association was significant among men but not women. Conclusion: Retrospectively reported childhood picky eating may function as a developmental correlate, rather than a deterministic risk factor, for orthorexic tendencies. FAU - Grabois, Maya AU - Grabois M AD - The Nutritional Psychology Laboratory, Tel-Hai Academic College, North District, Israel. RINGGOLD: 54625 AD - Psychology Department, Tel-Hai Academic College, North District, Israel. FAU - Horovitz, Omer AU - Horovitz O AUID- ORCID: 0000-0003-2094-7448 AD - The Nutritional Psychology Laboratory, Tel-Hai Academic College, North District, Israel. RINGGOLD: 54625 AD - Psychology Department, Tel-Hai Academic College, North District, Israel. LA - eng PT - Journal Article DEP - 20260522 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 SB - IM OTO - NOTNLM OT - Orthorexic tendencies OT - developmental correlates OT - eating behavior OT - perfectionism OT - picky eating EDAT- 2026/05/22 12:35 MHDA- 2026/05/22 12:35 CRDT- 2026/05/22 11:33 PHST- 2026/05/22 12:35 [medline] PHST- 2026/05/22 12:35 [pubmed] PHST- 2026/05/22 11:33 [entrez] AID - 10.1177/02601060261454264 [doi] PST - aheadofprint SO - Nutr Health. 2026 May 22:2601060261454264. doi: 10.1177/02601060261454264. PMID- 42171301 OWN - NLM STAT- MEDLINE DCOM- 20260616 LR - 20260617 IS - 2042-650X (Electronic) IS - 2042-6496 (Linking) VI - 17 IP - 11 DP - 2026 Jun 8 TI - Associations of dietary diversity with type 2 diabetes in two Chinese cohorts: a multi-omics study. PG - 5142-5151 LID - 10.1039/d6fo01294a [doi] AB - Background: The role of overall dietary diversity in type 2 diabetes (T2D) risk remains uncertain, and the potential associations involving the gut microbiota and metabolism are poorly understood. We therefore aimed to elucidate the associations between dietary diversity and T2D development and to explore the roles of gut microbiota and metabolism in two large-scale Chinese cohorts. Methods: This study included 8103 participants aged 18-80 years from the WELL-China cohort as the discovery cohort and 2020 from the Lanxi cohort as the validation cohort. Dietary diversity score (DDS) was calculated using a validated food frequency questionnaire and categorized as high-, medium-, or low-DDS groups. The primary outcome was incident T2D during a median follow-up period of 6.2 years. 16S rRNA sequencing was used to analyze the gut microbiota, while untargeted metabolomics was employed for plasma metabolite profiling. Cox regression was applied in all analyses. Results: High DDS was associated with a lower risk of T2D, with a hazard ratio of 0.71 [p = 0.039; 95% CI: 0.50 to 0.98] compared with low DDS. Eleven bacterial genera and 15 metabolites were identified between the high- and low- DDS groups. Among them, two genera (e.g., Blautia) and four metabolites, such as L-pipecolic acid, enriched in the high-DDS group were negatively correlated with incident T2D, whereas two genera and two metabolites depleted in the high-DDS group showed positive associations. Furthermore, most metabolites enriched in the high-DDS group were positively associated with high-DDS-enriched genera and linked to protective pathways (e.g., vitamin B6 metabolism); opposite associations were observed for depleted metabolites, which were linked to steroid hormone biosynthesis, a pathway whose dysregulation is closely linked to insulin resistance. Conclusions: Higher dietary diversity was associated with a lower risk of T2D, which might be partially due to the combined effects and interactions of beneficial bacteria and anti-inflammatory metabolites. Our findings position DDS as an easily modifiable lifestyle factor for T2D prevention, supporting its integration into public health guidelines. FAU - Zhao, Boya AU - Zhao B AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, 866 Yu-hang-tang Road, Hangzhou, Zhejiang, 310058 China. zjuhewei@zju.edu.cn. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Li, Yuwei AU - Li Y AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, 866 Yu-hang-tang Road, Hangzhou, Zhejiang, 310058 China. zjuhewei@zju.edu.cn. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Li, Siyu AU - Li S AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, 866 Yu-hang-tang Road, Hangzhou, Zhejiang, 310058 China. zjuhewei@zju.edu.cn. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Xu, Nuo AU - Xu N AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, 866 Yu-hang-tang Road, Hangzhou, Zhejiang, 310058 China. zjuhewei@zju.edu.cn. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Shi, Yuwei AU - Shi Y AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, 866 Yu-hang-tang Road, Hangzhou, Zhejiang, 310058 China. zjuhewei@zju.edu.cn. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Yu, Yuji AU - Yu Y AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, 866 Yu-hang-tang Road, Hangzhou, Zhejiang, 310058 China. zjuhewei@zju.edu.cn. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Zheng, Weifang AU - Zheng W AD - Lanxi Hospital of Traditional Chinese Medicine, Lanxi, Zhejiang, China. FAU - Wu, Yi-Hsuan AU - Wu YH AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, CA, USA. AD - Department of Epidemiology and Population Health, Stanford School of Medicine, Stanford University, Stanford, CA, USA. FAU - Hu, Emily AU - Hu E AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, CA, USA. FAU - Huang, Po-Kai AU - Huang PK AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, CA, USA. FAU - Lee, Eunhye AU - Lee E AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, CA, USA. FAU - Chang, Chi AU - Chang C AD - Office of Medical Education Research and Development, and Department of Epidemiology and Biostatistics, College of Human Medicine, Michigan State University, East Lansing, MI, USA. FAU - Lu, Ying AU - Lu Y AD - Department of Biomedical Data Science, Stanford School of Medicine, Stanford University, Stanford, CA, USA. FAU - John, Esther M AU - John EM AD - Department of Epidemiology and Population Health, Stanford School of Medicine, Stanford University, Stanford, CA, USA. FAU - Hsing, Ann W AU - Hsing AW AD - Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Stanford University, Stanford, CA, USA. AD - Department of Epidemiology and Population Health, Stanford School of Medicine, Stanford University, Stanford, CA, USA. AD - Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA, USA. FAU - He, Wei AU - He W AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, 866 Yu-hang-tang Road, Hangzhou, Zhejiang, 310058 China. zjuhewei@zju.edu.cn. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Binjiang Institute of Zhejiang University, Hangzhou, Zhejiang, China. FAU - Zhu, Shankuan AU - Zhu S AUID- ORCID: 0000-0002-9509-7364 AD - Department of Endocrinology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Chronic Disease Research Institute, School of Public Health, School of Medicine, Zhejiang University, 866 Yu-hang-tang Road, Hangzhou, Zhejiang, 310058 China. zjuhewei@zju.edu.cn. AD - Department of Nutrition and Food Hygiene, School of Public Health, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. AD - Binjiang Institute of Zhejiang University, Hangzhou, Zhejiang, China. LA - eng PT - Journal Article DEP - 20260608 PL - England TA - Food Funct JT - Food & function JID - 101549033 RN - 0 (RNA, Ribosomal, 16S) RN - Chinese people SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/epidemiology/microbiology/metabolism MH - Middle Aged MH - China/epidemiology MH - Female MH - Aged MH - Male MH - Adult MH - Gastrointestinal Microbiome MH - Multiomics MH - Aged, 80 and over MH - *Diet MH - Young Adult MH - Adolescent MH - Cohort Studies MH - RNA, Ribosomal, 16S MH - Bacteria/classification/genetics/isolation & purification MH - Metabolomics MH - East Asian People EDAT- 2026/05/22 12:34 MHDA- 2026/06/16 13:31 CRDT- 2026/05/22 08:38 PHST- 2026/06/16 13:31 [medline] PHST- 2026/05/22 12:34 [pubmed] PHST- 2026/05/22 08:38 [entrez] AID - 10.1039/d6fo01294a [doi] PST - epublish SO - Food Funct. 2026 Jun 8;17(11):5142-5151. doi: 10.1039/d6fo01294a. PMID- 42170221 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260522 LR - 20260813 IS - 2306-9740 (Print) IS - 2306-9740 (Electronic) IS - 2306-9740 (Linking) VI - 12 DP - 2026 TI - mHealth apps for maternal mental well-being among pregnant and postpartum women: a systematic review. PG - 23 LID - 10.21037/mhealth-2025-72 [doi] LID - 23 AB - BACKGROUND: Maternal mental well-being during and after pregnancy is often overlooked, posing serious long-term risks to mothers and children. This systematic review aims to synthesize research on mobile health (mHealth) applications (apps) designed to support perinatal and postpartum mental well-being, with a focus on their design characteristics, intervention approaches, and reported effectiveness. METHODS: We conducted a systematic review following the PRISMA 2020 guidelines. PubMed and Scopus were searched up to August 2025. Studies were included if they reported original research on mHealth apps targeting maternal mental well-being during or after pregnancy with a diagnostic or intervention component for mental health. Review papers, conference abstracts, and studies without an mHealth component were excluded. RESULTS: From 2,127 articles, 15 met the inclusion criteria. These studies, published between 2017 and 2024, evaluated 13 distinct mHealth apps targeting primarily anxiety (12 studies), depression (8 studies), and stress (4 studies). Across all 15 studies, 24 screening methods were reported. Apps delivered interventions including mindfulness and guided meditation (7 studies) and cognitive behavioral therapy (CBT)-based tools and mood tracking (7 studies). Six app feature categories were identified: mental health screening, physical and mental well-being exercises and meditation, health education, visual design elements, healthcare support, and additional support features. Usability and engagement were most commonly evaluated using questionnaires and surveys (4 studies) and the Mobile Application Rating Scale (MARS) (3 studies). Six studies reported positive outcomes for depression symptoms. Common methodological limitations included small sample sizes, high dropout rates, and lack of long-term follow-up, constraining the generalizability of findings. CONCLUSIONS: This review demonstrates the potential of mHealth apps as accessible tools for supporting maternal mental well-being during pregnancy and the postpartum period. Clinicians should regard these tools as supplementary rather than standalone interventions until larger-scale efficacy trials are available. App developers are encouraged to design solutions that span both prenatal and postnatal periods, address multiple mental health conditions simultaneously, integrate validated screening methods, and combine health education, therapeutic, and behavioral support within a single platform. Future research should prioritize robust, longitudinal trials with diverse populations and standardized outcome measures to establish the evidence base needed for broader integration of mHealth into perinatal care. CI - (c) AME Publishing Company. FAU - Mohtasim, Syed Niaz AU - Mohtasim SN AD - Center for Computational & Data Sciences, Independent University, Bangladesh, Dhaka, Bangladesh. FAU - Arpita, Faiza Omar AU - Arpita FO AD - Center for Computational & Data Sciences, Independent University, Bangladesh, Dhaka, Bangladesh. FAU - Ahmed, Istiaq AU - Ahmed I AD - Center for Computational & Data Sciences, Independent University, Bangladesh, Dhaka, Bangladesh. FAU - Islam, Ashraful AU - Islam A AD - Center for Computational & Data Sciences, Independent University, Bangladesh, Dhaka, Bangladesh. FAU - Amin, M Ashraful AU - Amin MA AD - Center for Computational & Data Sciences, Independent University, Bangladesh, Dhaka, Bangladesh. FAU - Chaudhry, Beenish Moalla AU - Chaudhry BM AD - School of Computing and Informatics, University of Louisiana at Lafayette, Lafayette, LA, USA. LA - eng PT - Journal Article PT - Review DEP - 20260424 PL - China TA - Mhealth JT - mHealth JID - 101678564 PMC - PMC13187566 OTO - NOTNLM OT - Mobile health (mHealth) OT - digital health OT - mental well-being OT - postpartum OT - pregnancy COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://mhealth.amegroups.com/article/view/10.21037/mhealth-2025-72/coif). B.M.C. serves as an unpaid editorial board member of mHealth from March 2025 to December 2026. The other authors have no conflicts of interest to declare. EDAT- 2026/05/22 06:37 MHDA- 2026/05/22 06:38 PMCR- 2026/04/24 CRDT- 2026/05/22 04:30 PHST- 2025/11/05 00:00 [received] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/05/22 06:38 [medline] PHST- 2026/05/22 06:37 [pubmed] PHST- 2026/05/22 04:30 [entrez] PHST- 2026/04/24 00:00 [pmc-release] AID - mh-12-2025-72 [pii] AID - 10.21037/mhealth-2025-72 [doi] PST - epublish SO - Mhealth. 2026 Apr 24;12:23. doi: 10.21037/mhealth-2025-72. eCollection 2026. PMID- 42168995 OWN - NLM STAT- MEDLINE DCOM- 20260719 LR - 20260824 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 May 21 TI - Prevalence and determinants of sedentary behavior among university students in Yemen: a national multicenter cross-sectional study. LID - 10.1186/s12889-026-27767-6 [doi] LID - 2182 AB - BACKGROUND: Sedentary behavior is increasingly recognized as an independent risk factor for adverse physical and mental health outcomes. University students are particularly vulnerable due to prolonged sitting associated with academic demands. However, data on SB among university students in Yemen remain limited. This study aimed to assess the prevalence, patterns, and determinants of sedentary behavior among Yemeni university students. METHODS: A multicenter cross-sectional study was conducted among 8,312 university students aged 18-30 years from 28 public and private universities across 10 Yemeni cities. Participants were recruited using a non-probability convenience sampling approach via online platforms, which may introduce selection bias. Data were collected using a web-based, self-administered questionnaire including sociodemographic characteristics and the validated Arabic version of the Sedentary Behavior Questionnaire (SBQ). Average daily sedentary time was calculated, and prolonged sedentary behavior was defined as >/= 7 h/day. Descriptive statistics and logistic regression analyses were performed to identify factors associated with prolonged sedentary behavior. RESULTS: The mean daily sedentary time was 326.3 +/- 211.4 min, and 28.6% of students reported prolonged sedentary behavior. Watching television was the most common sedentary activity, followed by academic work and phone use. Sedentary time was higher among females and younger students in descriptive analyses. In multivariable analysis, enrollment in private universities (OR = 1.87, 95% CI: 1.68-2.08), studying in scientific/engineering/technical (OR = 1.48, 95% CI: 1.30-1.68) or administrative/economic disciplines (OR = 1.31, 95% CI: 1.12-1.53), smoking (OR = 1.28, 95% CI: 1.12-1.47), and lack of access to university physical activity facilities (OR = 1.30, 95% CI: 1.16-1.47) were independently associated with higher odds of prolonged sedentary behavior. Older age was associated with lower odds (21-24 years: OR = 0.82; >/=25 years: OR = 0.64). CONCLUSION: Sedentary behavior is common among Yemeni university students, with certain groups at higher risk. These findings suggest that university-based strategies, such as improving access to physical activity facilities and promoting active lifestyles, may help reduce sedentary time and support student health. CI - (c) 2026. The Author(s). FAU - Al-Bawah, Naji AU - Al-Bawah N AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. Najialbawah@gmail.com. FAU - Baklola, Mohamed AU - Baklola M AUID- ORCID: 0000-0002-5572-0852 AD - Faculty of Medicine, Mansoura University Hospitals, Mansoura Universiry, Mansoura, Egypt. Mohamedbaklola2000@gmail.com. FAU - Arrabyee, Mohammed R AU - Arrabyee MR AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. mohammedarrabyee@gmail.com. FAU - Benmelouka, Amira Yasmine AU - Benmelouka AY AD - Faculty of Medicine, University of Algiers, Algiers, Algeria. FAU - Ramadan, Alaa AU - Ramadan A AD - Faculty of Medicine, South Valley University, Qena, Egypt. FAU - Mousa, Mariam Mohamed AU - Mousa MM AD - Faculty of Medicine, Menoufia University, Menoufia, Egypt. FAU - Al-Hemiary, Abdulrahman Saeed AU - Al-Hemiary AS AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Homil, Osamah AU - Homil O AD - Faculty of Medicine, Emirates International University, Sana'a, Yemen. FAU - Aladimi, Mohammed AU - Aladimi M AD - Faculty of Medicine, Emirates International University, Sana'a, Yemen. FAU - Ban Rafuid, Husam Addin AU - Ban Rafuid HA AD - Faculty of Medicine, Emirates International University, Sana'a, Yemen. FAU - Al-Tashi, Ibrahim Isam AU - Al-Tashi II AD - Faculty of Medicine, Emirates International University, Sana'a, Yemen. FAU - Almagrami, Abdulrhman Abdo AU - Almagrami AA AD - Faculty of Medicine, Saba Region University, Marib, Yemen. FAU - Al-Shaaby, Abdulkareem AU - Al-Shaaby A AD - Faculty of Medicine, 21 September University, Sana'a, Yemen. FAU - Al-Hamzi, Abdullah AU - Al-Hamzi A AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Al-Othrubi, Ziad Mohammed AU - Al-Othrubi ZM AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Sharyan, Ehab AU - Sharyan E AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Alaribi, Saif AU - Alaribi S AD - Faculty of Medicine, Emirates International University, Sana'a, Yemen. FAU - Ali, Ismail AU - Ali I AD - Faculty of Medicine, Jiblah University for Health and Medical Sciences, Ibb, Yemen. FAU - Arrabyee, Waseem B AU - Arrabyee WB AD - Faculty of Medicine, 21 September University, Sana'a, Yemen. FAU - Alharazi, Abdulmalik AU - Alharazi A AD - Faculty of Medicine, Emirates International University, Sana'a, Yemen. FAU - Al-Hendi, Mohammed AU - Al-Hendi M AD - Faculty of Medicine, Jiblah University for Health and Medical Sciences, Ibb, Yemen. FAU - Yahia, Fekri AU - Yahia F AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Alwajeeh, Tarheeb AU - Alwajeeh T AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Al-Jahmi, Amjed AU - Al-Jahmi A AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Al-Eryani, Ahmed AU - Al-Eryani A AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Qarih, Naqib AU - Qarih N AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Rashed, Mujahed AU - Rashed M AD - Faculty of Medicine and Health Sciences, Amran University, Amran, Yemen. FAU - Youssef, Youssef T AU - Youssef YT AD - Faculty of Medicine, Mansoura University Hospitals, Mansoura Universiry, Mansoura, Egypt. FAU - Helal, Mohamed Basyouni AU - Helal MB AD - Faculty of Medicine, Menoufia University, Menoufia, Egypt. FAU - Abdelrahman, Mahitab Mohamed AU - Abdelrahman MM AD - Nursing administration and education department, College of Nursing, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia. FAU - Elsehrawy, Mohamed Gamal AU - Elsehrawy MG AD - Nursing administration and education department, College of Nursing, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260521 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - *Sedentary Behavior MH - Cross-Sectional Studies MH - Universities MH - *Students/statistics & numerical data/psychology MH - Young Adult MH - Yemen/epidemiology MH - Adolescent MH - Male MH - Adult MH - Prevalence MH - Surveys and Questionnaires PMC - PMC13383506 OTO - NOTNLM OT - Lifestyle factors OT - Physical inactivity OT - Public health OT - Sedentary behavior OT - University students OT - Yemen OT - Young adults COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Institutional Review Board (IRB) of Amran University prior to study initiation (protocol code: 825). The study was conducted in accordance with established ethical standards for human research and adhered to the principles of the Declaration of Helsinki. Participation was voluntary, and participants were informed about the study objectives, the confidentiality and anonymity of their responses, and their right to withdraw at any time without consequences. Electronic informed consent was obtained from all participants before completing the questionnaire. No personally identifiable information was collected. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/22 06:32 MHDA- 2026/07/20 00:37 PMCR- 2026/05/21 CRDT- 2026/05/22 00:27 PHST- 2026/03/18 00:00 [received] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/07/20 00:37 [medline] PHST- 2026/05/22 06:32 [pubmed] PHST- 2026/05/22 00:27 [entrez] PHST- 2026/05/21 00:00 [pmc-release] AID - 10.1186/s12889-026-27767-6 [pii] AID - 27767 [pii] AID - 10.1186/s12889-026-27767-6 [doi] PST - epublish SO - BMC Public Health. 2026 May 21;26(1):2182. doi: 10.1186/s12889-026-27767-6. PMID- 42168987 OWN - NLM STAT- MEDLINE DCOM- 20260805 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 May 21 TI - Prevalence of overweight and obesity and their associations with lifestyle habits among late adolescents in the Northern Border Region of Saudi Arabia: a cross‑sectional study. LID - 10.1186/s12889-026-27537-4 [doi] LID - 2272 AB - BACKGROUND: Adolescent obesity is a growing public health problem worldwide, and Saudi data show a high and rising burden of excess weight among youth with marked regional and gender disparities. Late adolescence is a critical window in which lifestyle behaviours consolidate and track into adulthood. AIM: To estimate the prevalence of overweight and obesity (primary outcome) and to examine their associations with lifestyle habits, including physical activity, sedentary behaviour, sleep, and dietary patterns (secondary outcomes), among late adolescents in the Northern Border Region of Saudi Arabia. METHODS: A cross‑sectional study was conducted among 352 late adolescents (18-21 years) enrolled in high schools and universities in the Northern Border Region, selected from a finite population of 51,461 using Cochran's formula. Body mass index (BMI) was calculated from self‑reported weight/height, and classified according to WHO cut‑offs. Lifestyle habits were assessed using the validated Arab Teens Lifestyle (ATLS) questionnaire, which covers sociodemographic characteristics, physical activity, sedentary behaviour, sleep, and dietary habits. Associations between BMI categories and covariates were examined using Pearson's Chi-square tests and t‑tests/ANOVA, and multiple linear regression was used to identify factors independently associated with BMI. RESULTS: Among participants, 54.1% of those aged 18 years or younger were overweight, while 68.8% of those >18 years were obese (p =0.004). Males predominated in the overweight group (72.1%), whereas females accounted for most obese participants (59.7%; p <0.001). Lower family income (5,000 to less than 10,000 SAR) was associated with overweight (73.8%) and obesity (57.1%; p < 0.001). High screen time (>2 hours/day) was reported by 82.8% of overweight adolescents (p <0.001). High consumption of sugary and energy drinks was associated with higher BMI, whereas frequent fruit and vegetable intake was associated with significantly lower BMI (all p <0.001). In multivariable analysis, total physical activity was independently associated with lower BMI (B = -0.16, p<0.001), whereas a higher composite dietary score was modestly positively associated with BMI (B = 0.12, p<0.001). CONCLUSION: Overweight and obesity are common among late adolescents in the Saudi Northern Border Region and are closely linked to sociodemographic, behavioural, and dietary factors. Physical activity emerged as the key modifiable protective factor. In contrast, high screen time and frequent consumption of sugary drinks were associated with higher BMI, underscoring the need for targeted changes in food environments and opportunities for safe physical activity. CI - (c) 2026. The Author(s). FAU - Negm, Lobna Mohamed Mohamed Abu AU - Negm LMMA AUID- ORCID: 0000-0002-3824-1438 AD - Medical Surgical Nursing Department, Faculty of Nursing, Ain Shams University, Cairo, Egypt. dr.lubna.mohmmed@nursing.asu.edu.eg. AD - Emergency and Intensive Care Nursing Department, Faculty of Nursing, Northern Border University, Arar, Saudi Arabia. dr.lubna.mohmmed@nursing.asu.edu.eg. FAU - Aboelola, Taghreed Hussien AU - Aboelola TH AUID- ORCID: 0000-0002-7996-697X AD - Public Health Nursing Department, Faculty of Nursing, Northern Border University, Arar, Saudi Arabia. FAU - Mersal, Fathia Ahmed AU - Mersal FA AUID- ORCID: 0000-0002-6450-5097 AD - Public Health Nursing Department, Faculty of Nursing, Northern Border University, Arar, Saudi Arabia. FAU - Alanazi, Jawaher Mohammed AU - Alanazi JM AUID- ORCID: 0009-0009-8807-7785 AD - Bone marrow and stem cells Transplantation Department, Comprehensive Cancer Center, Second Health Cluster, King Fahad Medical City, Riyadh, Saudi Arabia. FAU - Alanazi, Rawan Khalid AU - Alanazi RK AUID- ORCID: 0009-0006-6874-7049 AD - Faculty of Nursing, Northern Border University, Arar, Saudi Arabia. FAU - Al-Shammari, Reem Ali Jalawi AU - Al-Shammari RAJ AUID- ORCID: 0009-0008-6736-0680 AD - Maternity and Pediatric Hospital, Northern Borders Health Cluster, Rafha, Saudi Arabia. FAU - Alanazi, Raghad Saad AU - Alanazi RS AUID- ORCID: 0009-0008-7373-8395 AD - Faculty of Nursing, Northern Border University, Arar, Saudi Arabia. FAU - Fawzy, Manal S AU - Fawzy MS AUID- ORCID: 0000-0003-1252-8403 AD - Center for Health Research, Northern Border University, Arar, Saudi Arabia. manal.darwish@nbu.edu.sa. FAU - Eltaib, Fatma Abdou Ahmed AU - Eltaib FAA AD - Medical Surgical Nursing Department, Faculty of Nursing, Ain Shams University, Cairo, Egypt. AD - Medical Surgical Nursing, Faculty of Nursing, Northern Border University, Arar, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260521 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Adolescent MH - Cross-Sectional Studies MH - Male MH - Female MH - *Life Style MH - Young Adult MH - Prevalence MH - *Overweight/epidemiology MH - Body Mass Index MH - Sedentary Behavior MH - *Pediatric Obesity/epidemiology MH - Exercise MH - Feeding Behavior PMC - PMC13440119 OTO - NOTNLM OT - Arab Teens Lifestyle Study (ATLS), Northern Border Region OT - Late-adolescent OT - Lifestyle habits OT - Obesity OT - Saudi Arabia COIS- Declarations. Ethics approval and consent to participate: "The study was approved by the Local Committee of Bioethics at Northern Border University, Saudi Arabia (approval number: 121/24/H). Informed consent was obtained from all participants before taking part." Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/22 06:32 MHDA- 2026/08/05 06:41 PMCR- 2026/05/21 CRDT- 2026/05/22 00:26 PHST- 2025/12/21 00:00 [received] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/08/05 06:41 [medline] PHST- 2026/05/22 06:32 [pubmed] PHST- 2026/05/22 00:26 [entrez] PHST- 2026/05/21 00:00 [pmc-release] AID - 10.1186/s12889-026-27537-4 [pii] AID - 27537 [pii] AID - 10.1186/s12889-026-27537-4 [doi] PST - epublish SO - BMC Public Health. 2026 May 21;26(1):2272. doi: 10.1186/s12889-026-27537-4. PMID- 42168392 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260921 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 6 DP - 2026 May 21 TI - Maternal PPI therapy during lactation: pantoprazole levels in human milk and possible neonatal implications. LID - 10.1007/s00431-026-07046-7 [doi] LID - 425 AB - Proton pump inhibitors (PPIs) are widely used for acid-related disorders, but limited data exist regarding their excretion into human breast milk. This study aimed to quantify pantoprazole levels in plasma and breast milk of lactating women and to assess potential infant exposure. Sixteen mothers who had discontinued breastfeeding and were prescribed 40 mg pantoprazole once daily participated. Blood and breast milk samples were collected on days 1 and 7 at 0, 1.5, 3, 4.5, and 6 h post-dose. Pantoprazole was quantified using a validated high-performance liquid chromatography (HPLC) method with omeprazole as the internal standard. Samples were extracted via liquid-liquid extraction, and the method was validated over a linear range of 0.03-1 microg/mL (LOQ 0.03 microg/mL). Pantoprazole was detected in 46% (69/150) of plasma samples and 17.4% (26/149) of breast milk samples. Plasma levels peaked at ~ 4.5 h, whereas breast milk concentrations peaked at 3-4.5 h on day 1 and at 3 h on day 7. The low detectability and consistently lower breast milk concentrations suggest limited transfer into breast milk. Pantoprazole levels in breast milk were consistently lower than plasma and infrequently detectable. CONCLUSION: This study, representing the largest series to date examining pantoprazole excretion during lactation, suggests that infant exposure via breast milk is low. These findings suggest that breastfeeding may be compatible with pantoprazole therapy, although caution is warranted. The data provide supportive evidence for clinical decision-making. WHAT IS KNOWN: * Proton pump inhibitors (PPIs) are widely prescribed during lactation, but robust safety and pharmacokinetic data for pantoprazole transfer into breast milk remain limited. * Current breastfeeding recommendations for PPIs are based largely on expert opinion and isolated case reports with limited milk sampling. WHAT IS NEW: * Peak concentrations occurred 3-4.5 hours post-dose, and milk levels were consistently much lower than plasma levels. * Pantoprazole was detected in few milk samples and at concentrations markedly lower than plasma levels, indicating negligible infant exposure and supporting breastfeeding compatibility during therapy. CI - (c) 2026. The Author(s). FAU - Bor, Serhat AU - Bor S AUID- ORCID: 0000-0001-5766-9598 AD - Ege Reflux Study Group, Division of Gastroenterology, Ege University School of Medicine, Izmir, Turkey. serhat.bor@ege.edu.tr. FAU - Ergun, Pelin AU - Ergun P AUID- ORCID: 0000-0002-3155-0633 AD - Ege Reflux Study Group, Division of Gastroenterology, Ege University School of Medicine, Izmir, Turkey. AD - Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, USA. FAU - Sahin, Selma AU - Sahin S AD - Ege University, ARGEFAR, Izmir, Turkey. FAU - Kipcak, Sezgi AU - Kipcak S AUID- ORCID: 0000-0003-0615-3844 AD - Ege Reflux Study Group, Division of Gastroenterology, Ege University School of Medicine, Izmir, Turkey. AD - Department of Medical Biology, Ege University School of Medicine, Izmir, Turkey. FAU - Tuncal, Akile AU - Tuncal A AUID- ORCID: 0000-0002-7442-1874 AD - Department of Medical Biochemistry, Cyprus Health and Social Sciences, University School of Medicine, Morphou, Republic of Cyprus. FAU - Karasulu, Ercument AU - Karasulu E AUID- ORCID: 0000-0002-3992-6201 AD - Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, Milwaukee, USA. LA - eng PT - Journal Article DEP - 20260521 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - D8TST4O562 (Pantoprazole) RN - 0 (Proton Pump Inhibitors) SB - IM MH - Humans MH - *Milk, Human/chemistry MH - Female MH - *Pantoprazole/blood/pharmacokinetics MH - *Proton Pump Inhibitors/pharmacokinetics/blood/analysis/therapeutic use MH - *Lactation/metabolism MH - Infant, Newborn MH - Adult MH - Breast Feeding MH - Chromatography, High Pressure Liquid PMC - PMC13194337 OTO - NOTNLM OT - Breast-feeding OT - Human breast milk OT - Lactation OT - Pantoprazole OT - Proton pump inhibitors COIS- Declarations. Ethical approval: Ethical approval was provided by Ege University Clinical Research Ethics Committee, Izmir, Turkiye (Approval No: 13-9/27). This study was conducted in accordance with the ethical principles of the Declaration of Helsinki. Competing interests: The authors declare no competing interests. EDAT- 2026/05/22 00:33 MHDA- 2026/05/22 00:34 PMCR- 2026/05/21 CRDT- 2026/05/21 23:31 PHST- 2026/01/28 00:00 [received] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/04/27 00:00 [revised] PHST- 2026/05/22 00:34 [medline] PHST- 2026/05/22 00:33 [pubmed] PHST- 2026/05/21 23:31 [entrez] PHST- 2026/05/21 00:00 [pmc-release] AID - 10.1007/s00431-026-07046-7 [pii] AID - 7046 [pii] AID - 10.1007/s00431-026-07046-7 [doi] PST - epublish SO - Eur J Pediatr. 2026 May 21;185(6):425. doi: 10.1007/s00431-026-07046-7. PMID- 42167926 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2472-1727 (Electronic) VI - 118 IP - 5 DP - 2026 May TI - Developmental Toxicity Evaluation of the Dietary Supplement Vinpocetine Using Mouse and Human 3D Gastruloids. PG - e70060 LID - 10.1002/bdr2.70060 [doi] AB - BACKGROUND: Vinpocetine is marketed as a dietary supplement for cognitive enhancement, despite the absence of regulatory requirements for comprehensive toxicity testing. The FDA has issued a warning against vinpocetine use by individuals of childbearing potential based on animal studies demonstrating impaired embryonic development. However, the relevance of these findings to human embryogenesis, as well as the contribution of vinpocetine's activity as a cyclic nucleotide metabolism modulator, remains unclear. To address these gaps, gastruloids derived from pluripotent stem cells may provide in vitro models of embryogenesis for investigating chemical impacts. METHODS: Gastruloids were generated from mouse P19C5 and human H9 pluripotent stem cells to evaluate the effects of vinpocetine, its major metabolite apovincaminic acid, and additional modulators of cyclic nucleotide metabolism. Morphological effects were measured using established morphometric parameters, and molecular effects were evaluated based on a previously validated panel of developmental regulator genes as sensitive biomarkers. RESULTS: Vinpocetine induced distinct morphological changes in mouse gastruloids at concentrations >/= 1 muM, whereas apovincaminic acid produced similar effects only at substantially higher concentrations. Other cyclic nucleotide-modulating compounds, including ITI-214, IBMX, forskolin, and cinaciguat, did not phenocopy vinpocetine-induced defects. In human gastruloids, vinpocetine impaired morphogenesis and altered developmental regulator expression at concentrations >/= 0.2 muM. CONCLUSIONS: Vinpocetine disrupts gastruloid development in both mouse and human models at concentrations commonly used to elicit purported neuroprotective effects, supporting animal-based evidence of developmental toxicity and demonstrating human relevance. These findings highlight reproductive safety concerns associated with vinpocetine and underscore the need for systematic toxicity evaluation of dietary supplements. CI - (c) 2026 Wiley Periodicals LLC. FAU - Maki, Alexia AU - Maki A AD - Yanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii, USA. FAU - Marikawa, Yusuke AU - Marikawa Y AUID- ORCID: 0000-0001-5720-5806 AD - Yanagimachi Institute for Biogenesis Research, Department of Anatomy, Biochemistry and Physiology, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii, USA. LA - eng GR - R03 ES037055/ES/NIEHS NIH HHS/United States GR - R03 HD120740/HD/NICHD NIH HHS/United States GR - HD120740/National Institute of Child Health and Human Development/ GR - ES037055/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PL - United States TA - Birth Defects Res JT - Birth defects research JID - 101701004 RN - 543512OBTC (vinpocetine) RN - 0 (Vinca Alkaloids) SB - IM MH - *Vinca Alkaloids/toxicity/pharmacology MH - Animals MH - Humans MH - Mice MH - *Dietary Supplements/toxicity/adverse effects MH - *Embryonic Development/drug effects MH - Pluripotent Stem Cells/drug effects MH - Toxicity Tests/methods MH - Cell Line PMC - PMC13249007 MID - NIHMS2179890 COIS- Conflict of Interest The authors declare no conflict of interest. EDAT- 2026/05/22 00:33 MHDA- 2026/05/22 00:34 PMCR- 2026/06/09 CRDT- 2026/05/21 21:52 PHST- 2026/05/04 00:00 [revised] PHST- 2026/01/28 00:00 [received] PHST- 2026/05/10 00:00 [accepted] PHST- 2026/05/22 00:34 [medline] PHST- 2026/05/22 00:33 [pubmed] PHST- 2026/05/21 21:52 [entrez] PHST- 2026/06/09 00:00 [pmc-release] AID - 10.1002/bdr2.70060 [doi] PST - ppublish SO - Birth Defects Res. 2026 May;118(5):e70060. doi: 10.1002/bdr2.70060. PMID- 42167647 OWN - NLM STAT- Publisher LR - 20261020 IS - 1527-5418 (Electronic) IS - 0890-8567 (Linking) DP - 2026 May 20 TI - Optimizing Pharmacological Treatment in Children and Adolescents With Major Depressive Disorder: An Individual Participant Data Analysis. LID - S0890-8567(26)00233-9 [pii] LID - 10.1016/j.jaac.2026.05.010 [doi] AB - OBJECTIVE: The specific influence of individual characteristics on antidepressant efficacy and tolerability in pediatric major depressive disorder (MDD) remains unclear. This study aimed to characterize subgroup-specific treatment efficacy and to establish a preliminary scientific foundation for precision psychiatry in pediatric MDD management based on available data. METHOD: An individual participant data (IPD) analysis of double-blind randomized trials (RCTs) was conducted to compare antidepressants with placebo for the acute treatment of MDD in children and adolescents. Subgroup analyses identified treatment outcome differences by participant characteristics, with mixed-effects models used to examine effect modifiers. Primary outcomes were efficacy (depressive symptom change, mean difference [MD]) and tolerability (adverse event-related withdrawals, odds ratio [OR]). Secondary outcomes included deterioration and suicide-related outcomes. The protocol is registered with PROSPERO (CRD42016051657). RESULTS: IPD from 10 of 40 eligible RCTs (2,584 participants) on 5 antidepressants (fluoxetine [n = 475], imipramine [n = 95], paroxetine [n = 413], desvenlafaxine [n = 358], duloxetine [n = 341]), and placebo [n = 902] were analyzed. Most trials had "some concerns" for risk of bias. There was also substantial missing data for key covariates (eg, 53% for family history of psychiatric disorders). Inconsistencies in the reporting and collection of suicide-related outcomes (ideation and attempts) limited our analyses. In the individual participant meta-analysis, subgroup analysis showed that fluoxetine was the only agent significantly more effective than placebo (MD = -2.43). Imipramine (OR = 5.43) and paroxetine (OR = 1.85) showed poor tolerability. In terms of subgroup analyses based on individual participant characteristics, fluoxetine demonstrated superior efficacy in children, female participants, White participants, healthy weight participants, and those with severe symptoms (MDs = -3.90 to -2.60). Fluoxetine also showed less deterioration in female participants (OR = 0.55, 95% CI = 0.37 to 0.83). No significant differences in suicide-related outcomes were observed across subgroups based on individual characteristics. CONCLUSION: These provide a preliminary understanding of one possible precision medicine framework for pediatric MDD, indicating that individual characteristics (age, sex, ethnicity, body mass index [BMI], symptom severity, family history) may influence treatment outcomes. Exploratory subgroup analyses suggest fluoxetine's efficacy may be more pronounced in certain populations: children, female participants, White individuals, healthy weight participants, and those with severe symptoms. These findings should be interpreted with caution as IPD was only available from a quarter of eligible clinical trials, introducing data availability bias. These findings also require further validation in more diverse cohorts. Universal suicide-related outcome assessment across all subgroups (regardless of individual characteristics) remains essential. Broader data sharing is needed to improve representativeness in future IPD analyses. STUDY REGISTRATION INFORMATION: Comparative efficacy and tolerability of new-generation antidepressants for major depressive disorder in children and adolescents: protocol of an individual patient data meta-analysis; https://www.crd.york.ac.uk/PROSPERO/view/CRD42016051657. CI - Copyright (c) 2026 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved. FAU - Xiang, Yajie AU - Xiang Y AD - Yongchuan Hospital of Chongqing Medical University, Chongqing, China; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Cuijpers, Pim AU - Cuijpers P AD - Amsterdam Public Health research institute, Vrije Universiteit Amsterdam, the Netherlands. FAU - Li, Wei AU - Li W AD - The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Chengdu Third People's Hospital, Chengdu, China. FAU - Bao, Qingyan AU - Bao Q AD - The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Weisz, John R AU - Weisz JR AD - Harvard University, Cambridge, Massachusetts. FAU - Shi, Jie AU - Shi J AD - National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China. FAU - Du, Xiaoyan AU - Du X AD - Yongchuan Hospital of Chongqing Medical University, Chongqing, China; The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Yang, Hongmei AU - Yang H AD - The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Barth, Jurgen AU - Barth J AD - Institute for Complementary and Integrative Medicine, University Hospital Zurich and University of Zurich, Zurich, Switzerland. FAU - Coghill, David AU - Coghill D AD - Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia. FAU - Leucht, Stefan AU - Leucht S AD - School of Medicine and Health, Technische Universitat Munchen, Munich, Germany. FAU - Hazell, Philip AU - Hazell P AD - Discipline of Psychiatry, Sydney Medical School, Concord West, New South Wales, Australia. FAU - Cohen, David AU - Cohen D AD - Hopital Pitie-Salpetriere, Institut des Systemes Intelligents et Robotiques, Sorbonne Universite, Paris, France. FAU - Ravindran, Arun V AU - Ravindran AV AD - Campbell Family Mental Health Research Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; University of Toronto, Toronto, Ontario, Canada. FAU - Michael, Kurt D AU - Michael KD AD - The Jed Foundation, New York, New York; Huntsman Mental Health Institute, University of Utah, Child Psychiatry, Salt Lake City, Utah. FAU - Teng, Teng AU - Teng T AD - The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Zhou, Xinyu AU - Zhou X AD - The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Lu, Lin AU - Lu L AD - National Institute on Drug Dependence and Beijing Key Laboratory of Drug Dependence, Peking University, Beijing, China; Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health (Peking University), National Clinical Research Center for Mental Disorders (Peking University Sixth Hospital), Beijing, China; Institute of Brain Science and Brain-inspired Research, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China. FAU - Xie, Peng AU - Xie P AD - The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: xiepeng@cqmu.edu.cn. LA - eng PT - Journal Article DEP - 20260520 PL - United States TA - J Am Acad Child Adolesc Psychiatry JT - Journal of the American Academy of Child and Adolescent Psychiatry JID - 8704565 SB - IM EIN - J Am Acad Child Adolesc Psychiatry. 2026 Jul 24:S0890-8567(26)01538-8. doi: 10.1016/j.jaac.2026.07.1226. PMID: 42498220 EIN - J Am Acad Child Adolesc Psychiatry. 2026 Oct 20:S0890-8567(26)02197-0. doi: 10.1016/j.jaac.2026.10.014. PMID: 42901237 OTO - NOTNLM OT - antidepressant OT - child and adolescent OT - depression OT - individual participant data EDAT- 2026/05/22 00:33 MHDA- 2026/05/22 00:33 CRDT- 2026/05/21 19:40 PHST- 2025/10/23 00:00 [received] PHST- 2026/04/05 00:00 [revised] PHST- 2026/05/13 00:00 [accepted] PHST- 2026/05/22 00:33 [pubmed] PHST- 2026/05/22 00:33 [medline] PHST- 2026/05/21 19:40 [entrez] AID - S0890-8567(26)00233-9 [pii] AID - 10.1016/j.jaac.2026.05.010 [doi] PST - aheadofprint SO - J Am Acad Child Adolesc Psychiatry. 2026 May 20:S0890-8567(26)00233-9. doi: 10.1016/j.jaac.2026.05.010. PMID- 42167393 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260903 IS - 1878-5476 (Electronic) IS - 1878-5476 (Linking) VI - 86 DP - 2026 Sep TI - Feasibility and acceptability of a social media-based physical activity intervention for college women. PG - 103154 LID - S1469-0292(26)00095-6 [pii] LID - 10.1016/j.psychsport.2026.103154 [doi] AB - College women are less physically active than male peers, highlighting the need for tailored physical activity (PA) interventions that address women's unique needs in collegiate settings. Social media platforms (e.g., Instagram) offer a promising avenue to deliver PA interventions using freely-available fitness influencer content. This single-arm study tested the feasibility of an 8-week social media-based intervention leveraging fitness influencer content to promote moderate-to-vigorous PA (MVPA) and muscle-strengthening activities. Researchers recruited insufficiently physically active college women aged 18-24. Intervention components included: 1) researcher-generated Instagram posts, 2) group chat, 3) content identification tool (Green or Red Flags), 4) researcher-selected fitness influencer content, and 5) Fitbit(R) accounts. Participants completed surveys at baseline, weeks 4 and 8 and a subset completed a semi-structured post-intervention interview. The primary outcomes were feasibility and acceptability (e.g., enrollment, retention, engagement); changes in possible outcomes of interest for a future efficacy trial were explored as secondary outcomes (e.g., increases in PA and psychosocial constructs (e.g. self-regulation)). Benchmarks of success were predefined for each outcome (e.g., retention: more than 75% complete the intervention). Of 25 who enrolled, 23 participants (M(age) = 20.3 +/- 1.8 years) completed the intervention. Enrollment (75.8% > 50%) and retention (92.0% > 75%) were successful, though not all primary outcome benchmarks were achieved (e.g., engagement). PA results were mixed (MVPA and muscle-strengthening activities) and some significant improvements in self-regulation (p = 0.02, 0.005) were observed. Findings suggest preliminary feasibility and acceptability of this novel approach. Results provide an important foundation for refinements to enhance engagement prior to further testing and development. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Lavoie, Hannah A AU - Lavoie HA AD - University of Florida, College of Health and Human Performance, Department of Health Education & Behavior, Gainesville, FL, United States. Electronic address: hlavoie@ufl.edu. FAU - McVay, Megan A AU - McVay MA AD - University of Florida, College of Health and Human Performance, Department of Health Education & Behavior, Gainesville, FL, United States. FAU - Pearl, Rebecca L AU - Pearl RL AD - University of Florida, College of Public Health and Health Professions, Department of Clinical and Health Psychology, Gainesville, FL, United States. FAU - Fisher, Carla L AU - Fisher CL AD - University of Florida, College of Medicine, Health Outcomes and Biomedical Informatics, Gainesville, FL, United States. FAU - Wilkins, Francesca L AU - Wilkins FL AD - University of Florida, College of Health and Human Performance, Department of Health Education & Behavior, Gainesville, FL, United States. FAU - Jake-Schoffman, Danielle E AU - Jake-Schoffman DE AD - University of Florida, College of Health and Human Performance, Department of Health Education & Behavior, Gainesville, FL, United States. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260520 PL - Netherlands TA - Psychol Sport Exerc JT - Psychology of sport and exercise JID - 101088724 SB - IM MH - Humans MH - Female MH - *Social Media MH - Feasibility Studies MH - *Exercise/psychology MH - Young Adult MH - Universities MH - Adolescent MH - *Health Promotion/methods MH - Students/psychology MH - Media Exposure OTO - NOTNLM OT - College women OT - Digital health OT - Intervention OT - Muscle-strengthening activity OT - Physical activity OT - Social media COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/22 00:33 MHDA- 2026/07/23 05:37 CRDT- 2026/05/21 19:37 PHST- 2025/11/01 00:00 [received] PHST- 2026/04/21 00:00 [revised] PHST- 2026/05/12 00:00 [accepted] PHST- 2026/07/23 05:37 [medline] PHST- 2026/05/22 00:33 [pubmed] PHST- 2026/05/21 19:37 [entrez] AID - S1469-0292(26)00095-6 [pii] AID - 10.1016/j.psychsport.2026.103154 [doi] PST - ppublish SO - Psychol Sport Exerc. 2026 Sep;86:103154. doi: 10.1016/j.psychsport.2026.103154. Epub 2026 May 20. PMID- 42166858 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260813 IS - 1879-0453 (Electronic) IS - 0163-6383 (Print) IS - 0163-6383 (Linking) VI - 83 DP - 2026 Jun TI - Assessing the feasibility of a wearable consumer device for capturing newborns' sleep patterns in naturalistic environments. PG - 102200 LID - S0163-6383(26)00023-8 [pii] LID - 10.1016/j.infbeh.2026.102200 [doi] AB - Newborn sleep plays a vital role in early neurological and physiological development and may have lasting consequences for infants' developmental trajectories. However, few methods capture high-density sleep data in naturalistic settings during the newborn period. We address this by assessing the utility of the Owlet Dream Sock for capturing sleep patterns, timing, and duration in the home. Thirty-nine newborns (51.30% female, M age = 9.38 days old, SD = 6.40) wore the Owlet Dream Sock for fourteen days during all sleep periods. Newborns exhibited two common types of sleep bouts, light-only bouts (awake --> light sleep --> awake sequences) and full sleep cycles (awake --> light sleep --> deep sleep --> light sleep --> awake sequences). On average, sleep bouts began around 11:48 AM, and newborns spent approximately 172 monitoring minutes awake, 536 in light sleep, and 54 in deep sleep per day. The duration of time spent awake and in light sleep did not change over the assessment period; however, both the duration of deep sleep and the number of full sleep cycles increased each week. While nighttime sleep minutes did not change, daytime sleep minutes decreased. The Owlet Dream Sock shows acceptable feasibility for capturing high-density newborn sleep data to capture developmental changes in sleep patterns over the first weeks of life. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Speck, Bailey AU - Speck B AD - Department of Psychology, University of Oregon, United States. Electronic address: bspeck@uoregon.edu. FAU - Matsunaga, Eric AU - Matsunaga E AD - Department of Psychology, University of Oregon, United States. FAU - El-Arabaty, S Amr AU - El-Arabaty SA AD - Department of Psychology, University of Oregon, United States. FAU - Aringer, Alexandra S AU - Aringer AS AD - Department of Psychology, University of Oregon, United States. FAU - Deboeck, Pascal R AU - Deboeck PR AD - Department of Psychology, University of Utah, United States. FAU - Salisbury, Amy L AU - Salisbury AL AD - School of Nursing, Virginia Commonwealth University, United States. FAU - Conradt, Elisabeth AU - Conradt E AD - Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, United States. FAU - Crowell, Sheila E AU - Crowell SE AD - Department of Psychology, University of Oregon, United States. LA - eng GR - RF1 MH132210/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20260521 PL - United States TA - Infant Behav Dev JT - Infant behavior & development JID - 7806016 SB - IM MH - Female MH - Humans MH - Infant, Newborn MH - Male MH - Actigraphy/instrumentation MH - Feasibility Studies MH - *Sleep Duration MH - Wakefulness/physiology MH - *Wearable Electronic Devices PMC - PMC13335413 MID - NIHMS2179647 OTO - NOTNLM OT - Actigraphy OT - Newborn OT - Owlet OT - Sleep OT - Sleep states OT - Sleep timing EDAT- 2026/05/22 00:33 MHDA- 2026/06/11 12:41 PMCR- 2026/07/06 CRDT- 2026/05/21 18:02 PHST- 2026/01/31 00:00 [received] PHST- 2026/04/24 00:00 [revised] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/06/11 12:41 [medline] PHST- 2026/05/22 00:33 [pubmed] PHST- 2026/05/21 18:02 [entrez] PHST- 2026/07/06 00:00 [pmc-release] AID - S0163-6383(26)00023-8 [pii] AID - 10.1016/j.infbeh.2026.102200 [doi] PST - ppublish SO - Infant Behav Dev. 2026 Jun;83:102200. doi: 10.1016/j.infbeh.2026.102200. Epub 2026 May 21. PMID- 42166361 OWN - NLM STAT- MEDLINE DCOM- 20260914 LR - 20260914 IS - 2769-707X (Electronic) IS - 2769-7061 (Linking) VI - 45 IP - 7 DP - 2026 Sep-Oct TI - Cell Membrane Capacitance and Characteristic Frequency Among Youth and Adults: Reference Data From NHANES 1999-2000. PG - 622-631 LID - 10.1080/27697061.2026.2665157 [doi] AB - OBJECTIVE: Cell membrane capacitance (Cm) and characteristic frequency (fc) are two lesser-studied bioelectrical characteristics that may provide valuable insight into cell membrane integrity, yet reference data on these variables are scant. This study aimed to report normative data for Cm and fc among youth and adult populations. Secondary aims were to compare Cm and fc between subgroups, compare 50 kHz to fc, and explore relationships between fc and fat-free mass (FFM). METHOD: A secondary analysis was performed using data from the 1999-2000 U.S. National Health and Nutrition Examination Survey data set, including bioelectrical impedance spectroscopy data from male and female youth (8-17 years) and adults (18-49 years) to report reference data. Mann-Whitney U comparisons between sex and age subgroups and one-sample Wilcoxon rank test comparing fc to the common 50-kHz approximation were also conducted. RESULTS: Cm and fc ranged among youth (Cm = 0.43-4.57 nF; fc = 20.0-95.0 kHz) and adults (Cm = 0.65-4.68 nF; fc = 26.0-89.0 kHz). The youth group had significantly lower Cm (p < .001) and higher fc (p < .001) than the adults, while males had significantly higher Cm (p < .001) and lower fc (p < .001) than females. Compared to 50 kHz, fc was 9.0 kHz higher in youth (p < .001) and 7.0 kHz lower in adults (p < .001), while being 4.0 kHz lower with all ages combined (p < .001). CONCLUSIONS: Cm appears to mirror expected FFM differences between youths and adults and between males and females, while fc appears to have a largely inverse relationship with FFM, although the relationship is quadratic with a nadir near 35 to 40 kHz in adulthood. Cm and fc may have potential as noninvasive and clinically practical indicators of cell membrane functionality and maturation, although more research is needed to examine longitudinal validity of these measures alongside direct cellular observation. FAU - Lafontant, Kworweinski AU - Lafontant K AUID- ORCID: 0000-0002-8756-9827 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. FAU - Robinson, Marcus AU - Robinson M AUID- ORCID: 0009-0008-3817-8695 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. FAU - Sterner, Danielle A AU - Sterner DA AUID- ORCID: 0009-0007-4701-4070 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. FAU - Lebron, Modesto A AU - Lebron MA AUID- ORCID: 0000-0002-2636-4318 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. AD - Department of Kinesiology, Mississippi State University, Starkville, Mississippi, USA. FAU - Antonio, Brandi AU - Antonio B AUID- ORCID: 0009-0009-1083-8281 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. FAU - Livingston, Jack AU - Livingston J AUID- ORCID: 0009-0009-0356-9749 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. FAU - Smith, Sofea AU - Smith S AUID- ORCID: 0009-0005-7673-4697 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. FAU - Rossi, Carlo AU - Rossi C AUID- ORCID: 0000-0002-1208-1034 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. AD - Sport and Exercise Research Unit, Department of Psychology, Educational Science, and Human Movement, University of Palermo, Palermo, Italy. FAU - Stout, Jeffrey R AU - Stout JR AUID- ORCID: 0000-0001-6114-1649 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. FAU - Fukuda, David H AU - Fukuda DH AUID- ORCID: 0000-0002-4299-7764 AD - Physiology of Work and Exercise Response (POWER) Lab, Institute of Exercise Physiology and Rehabilitation Science, University of Central Florida, Orlando, Florida, USA. LA - eng PT - Journal Article DEP - 20260521 PL - United States TA - J Am Nutr Assoc JT - Journal of the American Nutrition Association JID - 9918300687506676 SB - IM MH - Humans MH - Female MH - Male MH - Nutrition Surveys MH - Adolescent MH - Electric Impedance MH - Adult MH - Reference Values MH - Child MH - *Cell Membrane/physiology MH - Middle Aged MH - Young Adult MH - *Body Composition MH - *Electric Capacitance MH - United States OTO - NOTNLM OT - Bioimpedance OT - bioelectrical impedance analysis OT - bioelectrical impedance spectroscopy OT - life-span OT - normative EDAT- 2026/05/21 18:32 MHDA- 2026/09/14 17:40 CRDT- 2026/05/21 13:03 PHST- 2026/09/14 17:40 [medline] PHST- 2026/05/21 18:32 [pubmed] PHST- 2026/05/21 13:03 [entrez] AID - 10.1080/27697061.2026.2665157 [doi] PST - ppublish SO - J Am Nutr Assoc. 2026 Sep-Oct;45(7):622-631. doi: 10.1080/27697061.2026.2665157. Epub 2026 May 21. PMID- 42166107 OWN - NLM STAT- MEDLINE DCOM- 20261023 LR - 20261025 IS - 2212-1358 (Electronic) IS - 2212-134X (Print) IS - 2212-134X (Linking) VI - 14 IP - 6 DP - 2026 Nov TI - Predicting pulmonary function in adolescent idiopathic scoliosis: is a simple 2D radiograph still the winner? PG - 2223-2231 LID - 10.1007/s43390-026-01433-8 [doi] AB - PURPOSE: While 3D radiographic parameters are increasingly used to assess adolescent idiopathic scoliosis (AIS), barriers to 3D imaging limit their routine use. 2D-to-3D prediction algorithms have been proposed as a substitute. This study sought to determine if a predicted 3D kyphosis, derived from 2D images, is a more robust predictor of FEV1 in patients with AIS than a traditional 2D analysis. METHODS: A retrospective, cross-sectional review of 259 AIS patients with surgical-range thoracic curves (> 40 degrees ) was performed. We built two multivariate linear regression models to predict FEV1. Due to structural multicollinearity, the deformity measures were tested separately. Model A included Main Thoracic Cobb, BMI, and Age. Model B included Predicted 3D T5-T12 Kyphosis, BMI, and Age. The models were compared using the Akaike Information Criterion (AIC) and adjusted. RESULTS: The cohort (87% female, mean age 15.7 +/- 3.3 years) presented with severe deformities (mean Main Thoracic Cobb 68.4 degrees +/- 16.5 degrees ) and widespread restrictive impairment (71%). Multivariate Analysis revealed that Model A, (2D Main Thoracic Cobb) was statistically superior to Model B (Predicted 3D T5 - T12 Kyphosis) with a lower AIC (-292.5 vs. -265.9) and a higher adjusted R(2) (0.241 vs. 0.159). All factors were significant independent predictors. CONCLUSION: The predicted 3D-based model was not superior, while a parsimonious 2D-based multivariate model including Main Thoracic Cobb, BMI, and Age explained a significantly larger proportion of the variance in FEV1. This specific 2D-to-3D prediction algorithm is an imperfect proxy and is not a valid substitute for true 3D imaging in predicting pulmonary risk. CI - (c) 2026. The Author(s). FAU - de Oliveira, Rafael Garcia AU - de Oliveira RG AUID- ORCID: 0000-0002-9160-9246 AD - Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil. rafagaroli@gmail.com. AD - Yale University, New Haven, USA. rafagaroli@gmail.com. FAU - de Barros Filho, Tarcisio Eloy Pessoa AU - de Barros Filho TEP AD - Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil. FAU - de Oliveira Araujo, Alex AU - de Oliveira Araujo A AD - Department of Orthopedic Surgery, Pediatrics and Rehabilitation, SARAH Network of Rehabilitation Hospitals, Brasilia, Brazil. FAU - Marcon, Raphael Martus AU - Marcon RM AD - Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil. FAU - Varthi, Arya AU - Varthi A AD - Yale University, New Haven, USA. FAU - Tuason, Dominick AU - Tuason D AD - Yale University, New Haven, USA. FAU - Gomes, Cicero Ricardo AU - Gomes CR AD - Department of Orthopedic Surgery, Pediatrics and Rehabilitation, SARAH Network of Rehabilitation Hospitals, Brasilia, Brazil. FAU - Cristante, Alexandre Fogaca AU - Cristante AF AD - Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil. LA - eng PT - Journal Article DEP - 20260521 PL - England TA - Spine Deform JT - Spine deformity JID - 101603979 SB - IM MH - Humans MH - *Scoliosis/diagnostic imaging/physiopathology MH - Adolescent MH - Female MH - Retrospective Studies MH - Cross-Sectional Studies MH - Male MH - *Kyphosis/diagnostic imaging/physiopathology MH - Imaging, Three-Dimensional/methods MH - *Radiography/methods MH - Respiratory Function Tests MH - Predictive Value of Tests MH - Thoracic Vertebrae/diagnostic imaging MH - *Lung/physiopathology/diagnostic imaging MH - Forced Expiratory Volume PMC - PMC13690850 OTO - NOTNLM OT - 2D-to-3D prediction OT - Adolescent idiopathic scoliosis OT - Multivariate regression OT - Pulmonary function COIS- Declarations. Ethical approval: This study was approved by the appropriate institutional ethics committee EDAT- 2026/05/21 12:37 MHDA- 2026/10/23 23:30 PMCR- 2026/05/21 CRDT- 2026/05/21 11:15 PHST- 2025/11/04 00:00 [received] PHST- 2026/05/10 00:00 [accepted] PHST- 2026/10/23 23:30 [medline] PHST- 2026/05/21 12:37 [pubmed] PHST- 2026/05/21 11:15 [entrez] PHST- 2026/05/21 00:00 [pmc-release] AID - 10.1007/s43390-026-01433-8 [pii] AID - 1433 [pii] AID - 10.1007/s43390-026-01433-8 [doi] PST - ppublish SO - Spine Deform. 2026 Nov;14(6):2223-2231. doi: 10.1007/s43390-026-01433-8. Epub 2026 May 21. PMID- 42165931 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260828 IS - 1864-6433 (Electronic) IS - 0914-7187 (Print) IS - 0914-7187 (Linking) VI - 40 IP - 9 DP - 2026 Sep TI - 18 F-FDG PET/CT Derived Volumetric Parameters Can Predict Outcome in Pediatric Ewing Sarcoma. PG - 1121-1130 LID - 10.1007/s12149-026-02229-6 [doi] AB - OBJECTIVE: To evaluate the prognostic and predictive value of metabolic and volumetric parameters obtained from baseline (PET1) and post-chemotherapy (PET2) 18 F-FDG PET/CT in pediatric Ewing sarcoma (EWS) patients, focusing on their associations with histopathologic response, metastatic presentation, overall survival (OS), and progression-free survival (PFS). METHODS: This retrospective single tertiary academic center study included 55 pediatric EWS patients who underwent PET1. Twenty-four patients also had PET2. SUVmax, SUVpeak, metabolic tumor volume (MTV), total lesion glycolysis (TLG) and their percentage changes (∆) between PET scans were calculated using absolute (SUV 2.0 and 2.5) and relative (40% and 45%) thresholds. Anatomic tumor volume was also measured. Histopathologic evaluation was available for 40 patients with PET1 and 18 patients with PET2. Associations were analyzed using logistic and Cox regression models. RESULTS: Baseline metabolic and volumetric PET parameters were significantly higher in patients with presenting metastasis. Among these, TLG (45%) was identified as the only independent predictor of metastatic presentation (OR = 1.026, p = 0.019). Baseline MTV (2.0) was independently associated with shorter OS (HR = 1.026, p = 0.003) and PFS (HR = 1.035, p = 0.038). Combined stratification using MTV (2.0) and histologic response revealed that patients with an unfavorable histologic response but low MTV demonstrated superior OS and PFS rates than those with an unfavorable response and high MTV. The survival outcomes of patients with a favorable histologic response and high MTV were comparable to those with an unfavorable response and low MTV. However, PET parameters did not reliably predict histopathologic response in this cohort. CONCLUSIONS: Baseline MTV (2.0) demonstrated prognostic value for OS and PFS, while TLG (45%) independently predicted metastatic presentation in pediatric EWS. The combination of MTV (2.0) and histologic response appears to provide complementary prognostic information. Prospective, multicenter studies with standardized imaging and treatment protocols are warranted to validate the role of volumetric 18 F-FDG PET parameters in clinical risk stratification. CI - (c) 2026. The Author(s). FAU - Soydas-Turan, Basak AU - Soydas-Turan B AUID- ORCID: 0000-0003-3425-751X AD - Department of Nuclear Medicine, Kastamonu Education and Research Hospital, Kastamonu, Turkiye. basaksoydas@hotmail.com. AD - Faculty of Medicine, Department of Nuclear Medicine, Hacettepe University, Ankara, Turkiye. basaksoydas@hotmail.com. FAU - Volkan-Salanci, Bilge AU - Volkan-Salanci B AD - Faculty of Medicine, Department of Nuclear Medicine, Hacettepe University, Ankara, Turkiye. FAU - Aydin, Burca AU - Aydin B AD - Faculty of Medicine, Department of Pediatric Oncology, Hacettepe University, Ankara, Turkiye. FAU - Kiratli, Pinar AU - Kiratli P AD - Faculty of Medicine, Department of Nuclear Medicine, Hacettepe University, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260521 PL - Japan TA - Ann Nucl Med JT - Annals of nuclear medicine JID - 8913398 RN - 0Z5B2CJX4D (Fluorodeoxyglucose F18) SB - IM MH - Humans MH - Female MH - *Sarcoma, Ewing/diagnostic imaging/pathology MH - *Fluorodeoxyglucose F18 MH - *Positron Emission Tomography Computed Tomography MH - Male MH - Child MH - Retrospective Studies MH - Adolescent MH - Tumor Burden MH - Prognosis MH - Treatment Outcome MH - Child, Preschool MH - *Bone Neoplasms/diagnostic imaging/pathology PMC - PMC13506628 OTO - NOTNLM OT - 18F-FDG PET/CT OT - Ewing sarcoma OT - Histopathologic response OT - Metabolic OT - Pediatric OT - Survival OT - Volumetric EDAT- 2026/05/21 12:34 MHDA- 2026/08/25 17:35 PMCR- 2026/05/21 CRDT- 2026/05/21 11:05 PHST- 2026/03/18 00:00 [received] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/08/25 17:35 [medline] PHST- 2026/05/21 12:34 [pubmed] PHST- 2026/05/21 11:05 [entrez] PHST- 2026/05/21 00:00 [pmc-release] AID - 10.1007/s12149-026-02229-6 [pii] AID - 2229 [pii] AID - 10.1007/s12149-026-02229-6 [doi] PST - ppublish SO - Ann Nucl Med. 2026 Sep;40(9):1121-1130. doi: 10.1007/s12149-026-02229-6. Epub 2026 May 21. PMID- 42165722 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 0971-5916 (Print) IS - 0971-5916 (Linking) VI - 163 IP - 4 DP - 2026 Apr TI - Machine learning-based prediction of inflammation adjusted iron deficiency anaemia using blood cell indices. PG - 469-476 LID - 10.25259/IJMR_1500_2025 [pii] AB - Background and objectives Diagnosis of iron deficiency anaemia (IDA), where both anaemia and iron deficiency coexist, is essential to improve the precision of iron treatment. The serum ferritin, a marker of iron deficiency, is an acute phase protein, requires adjustment for inflammation prior to using it for diagnosis of IDA. The blood cell indices (referred as complete blood counts, CBC) help in identifying the underlying cause of anaemia and presence of inflammation, both of which could be utilised for differential diagnosis of IDA. We conducted this study to evaluate machine learning (ML) models for predicting inflammation-adjusted IDA from CBC data. Methods We utilised CBC data from National Health and Nutrition Examination Survey (NHANES 2017-2023) of women of reproductive age (15-50 yr age, n=3604) and evaluated the performance of ML models to predict the inflammation adjusted IDA, in terms of sensitivity and specificity. We validated the performance of the optimised random forest (RF)- ML model, on women of reproductive age data set from India (n=381) in predicting the IDA, and haemoglobin response to iron treatment. Results The optimised RF model predicted the inflammation adjusted IDA, solely based on CBC, with sensitivity and specificity of approximately 95% either on the test or validation data. In those predicted to have IDA (2.3+/-1.6 g/dL, n=283), the haemoglobin increments due to iron therapy was markedly higher compared to those predicted to have non-IDA (0.31+/-0.67 g/dL, n=98). Interpretation and conclusions These findings suggest that it is possible to predict inflammation adjusted IDA with high sensitivity and specificity with ML models using CBC data. FAU - Palika, Ravindranadh AU - Palika R AD - ICMR-National Institute of Nutrition, Hyderabad, Telangana, India. FAU - Dasi, Teena AU - Dasi T AD - ICMR-National Institute of Nutrition, Hyderabad, Telangana, India. FAU - Parasannanavar, Devraj J AU - Parasannanavar DJ AD - ICMR-National Institute of Nutrition, Hyderabad, Telangana, India. FAU - Banjara, Santosh Kumar AU - Banjara SK AD - ICMR-National Institute of Nutrition, Hyderabad, Telangana, India. FAU - Kulkarni, Bharati AU - Kulkarni B AD - ICMR-National Institute of Nutrition, Hyderabad, Telangana, India. FAU - Pullakhandam, Raghu AU - Pullakhandam R AD - ICMR-National Institute of Nutrition, Hyderabad, Telangana, India. LA - eng PT - Journal Article PL - United States TA - Indian J Med Res JT - The Indian journal of medical research JID - 0374701 RN - 9007-73-2 (Ferritins) RN - E1UOL152H7 (Iron) SB - IM MH - Humans MH - Female MH - *Anemia, Iron-Deficiency/blood/diagnosis/epidemiology/pathology MH - *Machine Learning MH - *Inflammation/blood/pathology/diagnosis MH - Adult MH - Middle Aged MH - Ferritins/blood MH - Blood Cell Count MH - Adolescent MH - Random Forest MH - Iron/blood MH - Young Adult MH - Predictive Learning Models MH - India/epidemiology MH - Nutrition Surveys MH - Prediction Algorithms MH - Classification Algorithms PMC - PMC13224302 OTO - NOTNLM OT - Anaemia OT - Blood cell indices OT - Complete blood counts OT - Iron deficiency OT - Machine learning OT - Random forest OT - Serum ferritin OT - Women of reproductive age COIS- None. EDAT- 2026/05/21 12:36 MHDA- 2026/05/21 12:37 PMCR- 2026/04/01 CRDT- 2026/05/21 10:04 PHST- 2025/06/11 00:00 [received] PHST- 2025/12/21 00:00 [accepted] PHST- 2026/05/21 12:37 [medline] PHST- 2026/05/21 12:36 [pubmed] PHST- 2026/05/21 10:04 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - 10.25259/IJMR_1500_2025 [pii] AID - 10.25259/IJMR_1500_2025 [doi] PST - ppublish SO - Indian J Med Res. 2026 Apr;163(4):469-476. doi: 10.25259/IJMR_1500_2025. PMID- 42165382 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260901 IS - 1099-0496 (Electronic) IS - 1099-0496 (Linking) VI - 61 IP - 5 DP - 2026 May TI - Reliability of Home Sleep Apnea Test as a Diagnostic Modality in Children With Obstructive Sleep Apnea- a Systematic Review. PG - e71674 LID - 10.1002/ppul.71674 [doi] AB - BACKGROUND: The incidence of pediatric sleep disordered breathing has increased in the last decade because of many factors, such as childhood obesity, metabolic syndrome, and access to better diagnostic methods. OSA peaks between 2 and 8 years in children. Early diagnosis is recommended to prevent long-term complications. While PSG is the gold standard for diagnosis, it may not be feasible in certain circumstances; hence, HSAT is now being increasingly used to screen and diagnose OSA. METHODS: This review was conducted using the methodology in the "Cochrane handbook on systematic reviews". PRISMA flowchart was used to report the results. The risk of bias assessment was done using the "Cochrane handbook for systematic review reviews tool for Interventional studies". All studies were analysed using the Joanna Briggs Institute's critical appraisal tool. RESULTS: A total of nine studies were included in this review. Of these, only three studies employed simultaneous HSAT and PSG testing to evaluate the validity of HSAT indices. In one of the largest studies comparing HSAT with PSG, the mean AHI observed was 2.5 +/- 3 for HSAT and 2.7 +/- 2.9 for PSG (p > 0.05), indicating that the diagnostic yields of both methods were nearly equivalent. In studies utilizing HSAT alone, the mean apnea-hypopnea index (AHI) ranged from 0.8 to 10.3 events per hour in healthy children, compared to 2.2 to 13 events per hour in children with Down syndrome. CONCLUSIONS: Diagnosing sleep disordered breathing in children can be challenging in a laboratory setting. HSAT is cost-effective and better tolerated in the younger population compared to PSG. It is a reliable alternative to PSG when used with multiple channels, including EEG and capnography. CI - (c) 2026 Wiley Periodicals LLC. FAU - Zafar, Adnan AU - Zafar A AUID- ORCID: 0000-0002-9886-6819 AD - Pediatric Pulmonology Department, John Hopkins Aramco Healthcare, Dhahran, Saudi Arabia. FAU - Roman, Umme AU - Roman U AD - Karachi Medical and Dental College, Karachi, Pakistan. FAU - Haseeb, Abdul AU - Haseeb A AD - Karachi Medical and Dental College, Karachi, Pakistan. FAU - Akhtar, Taslim AU - Akhtar T AD - Pediatric Department, John Hopkins Aramco Healthcare, Dhahran, Saudi Arabia. LA - eng PT - Journal Article PT - Systematic Review PL - United States TA - Pediatr Pulmonol JT - Pediatric pulmonology JID - 8510590 SB - IM MH - Humans MH - *Sleep Apnea, Obstructive/diagnosis MH - Child MH - Polysomnography/methods MH - Reproducibility of Results MH - Child, Preschool OTO - NOTNLM OT - HSAT (home sleep apnea test) OT - PSG OT - apnea hypopnea index) OT - pediatric sleep EDAT- 2026/05/21 12:37 MHDA- 2026/05/21 12:38 CRDT- 2026/05/21 07:52 PHST- 2026/05/05 00:00 [revised] PHST- 2025/11/22 00:00 [received] PHST- 2026/05/13 00:00 [accepted] PHST- 2026/05/21 12:38 [medline] PHST- 2026/05/21 12:37 [pubmed] PHST- 2026/05/21 07:52 [entrez] AID - 10.1002/ppul.71674 [doi] PST - ppublish SO - Pediatr Pulmonol. 2026 May;61(5):e71674. doi: 10.1002/ppul.71674. PMID- 42165172 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260922 IS - 1751-7176 (Electronic) IS - 1524-6175 (Print) IS - 1524-6175 (Linking) VI - 28 IP - 5 DP - 2026 May TI - Risk Factors and Adverse Perinatal Outcomes in Severe Preeclampsia Complicated by HELLP Syndrome. PG - e70289 LID - 10.1111/jch.70289 [doi] LID - e70289 AB - This study investigated the risk factors and adverse perinatal outcomes of severe preeclampsia complicated with HELLP (Hemolysis, Elevated Liver Enzymes, and Low Platelet Count syndrome). A total of 170 patients with severe preeclampsia and 30 healthy pregnant women admitted to Wuxi Maternal and Child Health Hospital from January 2020 to October 2023 were enrolled. Of the 170 patients, 30 were complicated by HELLP syndrome and 140 were not; 30 healthy women served as controls. Clinical data, laboratory results, and pregnancy outcomes were compared. Risk factors were analyzed by logistic regression, and predictive efficacy was evaluated by ROC curves. Maternal and neonatal outcomes were assessed, and correlations with risk factors were analyzed. Patients with severe preeclampsia had higher age, BMI, and blood pressure but lower gestational weeks than controls (p < 0.05). In the HELLP group, D-dimer, bilirubin, liver enzymes, and lactate dehydrogenase (LDH) were significantly elevated, while platelets, albumin, and globulin were reduced compared with the non-HELLP group (p < 0.05). Multivariate analysis identified D-dimer and LDH as independent risk factors. ROC analysis showed AUCs of 0.929 for D-dimer, 0.937 for LDH, and 0.956 for their combination, with cutoffs of 3.26 mg/L and 261.60 U/L, yielding 94.4% sensitivity and 92.6% specificity. Adverse outcomes, including stillbirth, preterm labor, neonatal asphyxia, and MICU transfer, were more frequent in HELLP patients (p < 0.05). Elevated D-dimer and LDH correlated with fetal growth restriction and neonatal asphyxia. In conclusion, D-dimer and LDH are independent predictors of HELLP syndrome and adverse perinatal outcomes. CI - (c) 2026 The Author(s). The Journal of Clinical Hypertension published by Wiley Periodicals LLC. FAU - Sun, Chengfang AU - Sun C AD - Department of Toxicology, School of Public Health, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, China, Wuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Wuxi, China. FAU - Chen, Jiaying AU - Chen J AD - Department of Women Health Care, Wuxi School of Medicine, Wuxi Maternal and Child Health Hospital, Jiangnan University, Wuxi, Jiangsu Province, PR China. FAU - Gu, Hao AU - Gu H AD - Department of Women Health Care, Wuxi School of Medicine, Wuxi Maternal and Child Health Hospital, Jiangnan University, Wuxi, Jiangsu Province, PR China. FAU - Gu, Ying AU - Gu Y AD - Department of Obstetrics, Wuxi School of Medicine, Wuxi Maternal and Child Health Hospital, Jiangnan University, Wuxi, Jiangsu Province, PR China. FAU - Jiang, Minhui AU - Jiang M AD - Department of Women Health Care, Wuxi School of Medicine, Wuxi Maternal and Child Health Hospital, Jiangnan University, Wuxi, Jiangsu Province, PR China. FAU - Wu, Hongqin AU - Wu H AD - Department of Women Health Care, Wuxi School of Medicine, Wuxi Maternal and Child Health Hospital, Jiangnan University, Wuxi, Jiangsu Province, PR China. FAU - Sang, Xue AU - Sang X AD - Department of Women Health Care, Wuxi School of Medicine, Wuxi Maternal and Child Health Hospital, Jiangnan University, Wuxi, Jiangsu Province, PR China. FAU - Zhu, Hualong AU - Zhu H AD - Department of Toxicology, School of Public Health, Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, China, Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of The People's Republic of China, Hefei, Anhui, China. FAU - Feng, Yaling AU - Feng Y AD - Department of Toxicology, School of Public Health, Anhui Medical University, China; Wuxi Maternity and Child Health Care Hospital, Affiliated Women's Hospital of Jiangnan University, Wuxi, China. LA - eng GR - F202135/Jiangsu Maternal and Child Health Research Project/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Clin Hypertens (Greenwich) JT - Journal of clinical hypertension (Greenwich, Conn.) JID - 100888554 RN - EC 1.1.1.27 (L-Lactate Dehydrogenase) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *HELLP Syndrome/epidemiology/diagnosis/physiopathology MH - *Pre-Eclampsia/epidemiology/physiopathology/diagnosis MH - Adult MH - Risk Factors MH - Pregnancy Outcome/epidemiology MH - Infant, Newborn MH - China/epidemiology MH - ROC Curve MH - Severity of Illness Index MH - Case-Control Studies MH - Gestational Age MH - L-Lactate Dehydrogenase/blood PMC - PMC13240364 OTO - NOTNLM OT - HELLP syndrome OT - perinatal outcomes OT - risk factors OT - severe preeclampsia COIS- The authors declare no conflicts of interest. EDAT- 2026/05/21 06:32 MHDA- 2026/05/21 06:33 PMCR- 2026/05/21 CRDT- 2026/05/21 05:22 PHST- 2026/04/05 00:00 [revised] PHST- 2025/09/29 00:00 [received] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/05/21 06:33 [medline] PHST- 2026/05/21 06:32 [pubmed] PHST- 2026/05/21 05:22 [entrez] PHST- 2026/05/21 00:00 [pmc-release] AID - JCH70289 [pii] AID - 10.1111/jch.70289 [doi] PST - ppublish SO - J Clin Hypertens (Greenwich). 2026 May;28(5):e70289. doi: 10.1111/jch.70289. PMID- 42164096 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260521 LR - 20260813 IS - 2772-6533 (Electronic) IS - 2772-6533 (Linking) VI - 8 DP - 2026 Jun TI - Development and validation of risk factors lifestyle disorders scale (RFLDS): A cohort study. PG - 100307 LID - 10.1016/j.dialog.2026.100307 [doi] LID - 100307 AB - BACKGROUND: Adolescents are presumed to be healthy, but being a vulnerable group they are threatened with morbidities. Management of risk factors which concern and affect lifestyle disorders must begin during adolescence. The aim of study is to develop and validate a scale to assess risk factors leading to lifestyle disorders in quick and concise manner. METHODS: Risk Factor Lifestyle Disorders Scale (RFLDS) has been developed to identify risk factors of lifestyle disorders on low, borderline and high risk zones based on scientific exhaustive review of literature and expert consensus. Cross-sectional baseline data from planned cohort of 1000 school-based adolescents aged between 16 and 18 years from Tricity- Chandigarh, Panchkula and Mohali (India) was carried out. Three phase validation of content, construct and criterion validity has been conducted to develop the scale. Analyses were done through Item Total Reliability, Exploratory Factor Analysis, Cronbach's Alpha and Pearsons Correlation. FINDINGS: Results layout a structure of developed and validated scale. KMO measure of 0.720, Bartlett test of p < 0.0001, leading to seven factors consisting of 19 items of 64.75% variance and Cronbach's alpha of 0.68 was observed. Final scale consists of seven factors that emerged out of 19 identified items namely Socio-Economic Criteria (SEC), Nutritional Status (NS), Body Composition (BC), Low Risk Factor Foods (LRF), High Risk Factor Foods (HRF), Mental Health and Family and Personal History (MHFPH) and Sleep and Physical Activity (SPA). INTERPRETATION: Lifestyle disorders lead to deterioration in quality of life. Comprehensive RFLDS- Risk Factors Lifestyle Disorders Scale, validated in adolescents only, may be used for easy and quick assessment, addressal and prevention of lifestyle disorders. It may also be used as a screening tool in institutes, clinical and public health care systems to improve overall well-being, aligning with WHO's Sustainable Development Goal 3.4. CI - (c) 2026 The Authors. Published by Elsevier Inc. FAU - Singh, Kalyani AU - Singh K AD - Department of Foods and Nutrition, Government Home Science College, Chandigarh, India. FAU - Pradhan, Ritu AU - Pradhan R AD - Department of Foods and Nutrition, Government Home Science College, Chandigarh, India. LA - eng PT - Journal Article DEP - 20260503 PL - United States TA - Dialogues Health JT - Dialogues in health JID - 9918506184906676 PMC - PMC13186033 OTO - NOTNLM OT - Adolescents OT - Health OT - Lifestyle OT - Lifestyle disorders OT - Scale OT - Sustainable development goal 3.4 OT - WHO COIS- The authors have no declared conflicts of interest. EDAT- 2026/05/21 06:33 MHDA- 2026/05/21 06:34 PMCR- 2026/05/03 CRDT- 2026/05/21 04:37 PHST- 2025/04/30 00:00 [received] PHST- 2026/05/01 00:00 [revised] PHST- 2026/05/01 00:00 [accepted] PHST- 2026/05/21 06:34 [medline] PHST- 2026/05/21 06:33 [pubmed] PHST- 2026/05/21 04:37 [entrez] PHST- 2026/05/03 00:00 [pmc-release] AID - S2772-6533(26)00032-8 [pii] AID - 100307 [pii] AID - 10.1016/j.dialog.2026.100307 [doi] PST - epublish SO - Dialogues Health. 2026 May 3;8:100307. doi: 10.1016/j.dialog.2026.100307. eCollection 2026 Jun. PMID- 42163956 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260521 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Development and validation of an explainable machine learning-based risk prediction model for obesity in Chinese children and adolescents: a population-based study. PG - 1816724 LID - 10.3389/fnut.2026.1816724 [doi] LID - 1816724 AB - BACKGROUND: Childhood obesity represents a significant global public health challenge. Accurate and rapid prediction models for identifying obesity risk in children and adolescents are essential for facilitating early prevention and enabling timely interventions. However, interpretable and user-friendly obesity risk prediction models based on nationally representative data remain limited. This study aimed to develop and validate a model to predict current obesity risk among children and adolescents in China. METHODS: The models were developed using cross-sectional data from the 2017-2018 Physical Activity and Fitness in China-The Youth Study (PAFCTYS; n = 35,016) and were temporally validated with 2020 data (n = 3,495). Candidate predictors (n = 38), primarily encompassing physical activity, sedentary behavior, and sociodemographic variables, were measured concurrently with the outcome. The participants included individuals from 31 administrative regions across China. Features were identified using the Least Absolute Shrinkage and Selection Operator (LASSO) with recursive feature elimination (RFE), and predictive models were developed using eight different machine learning algorithms. The model's performance was evaluated using metrics such as AUC, sensitivity, specificity, Matthews Correlation Coefficient (MCC), and Brier score. The model was interpreted using the SHapley Additive exPlanation (SHAP) method. RESULTS: The random forest (RF) model outperformed all other models, achieving an AUC of 1.000 on the training set and 0.946 on the testing set. It also maintained good discriminative performance on the temporal validation dataset, with an AUC of 0.810. The RF model also shows the highest accuracy, specificity, and MCC, and the lowest Brier score. SHAP analysis indicates that parental BMI, using mobile electronic devices on weekdays, MVPA (moderate-to-vigorous physical activity), watching TV on weekdays, and sex are the top 5 most important features in the obesity risk prediction model. A web-based risk calculator based on the RF model has been successfully deployed. CONCLUSION: Using a large, nationally representative sample and readily available variables, we successfully developed and validated an obesity risk prediction model for Chinese children and adolescents using explainable machine learning techniques. The model can quickly and accurately assess an individual's current obesity risk, enabling healthcare agencies, schools, and parents to conduct large-scale obesity risk screening. CI - Copyright (c) 2026 Chen, Zhu and Chen. FAU - Chen, Zekai AU - Chen Z AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. FAU - Zhu, Lin AU - Zhu L AD - School of Sport and Health, Guangzhou Sport University, Guangzhou, China. AD - Innovative Research Center for Sports Science in the Guangdong-Hong Kong-Macao Greater Bay Area, Guangzhou Sport University, Guangzhou, China. FAU - Chen, Peijie AU - Chen P AD - School of Exercise and Health, Shanghai University of Sport, Shanghai, China. LA - eng PT - Journal Article DEP - 20260505 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13183532 OTO - NOTNLM OT - SHAP OT - children and adolescents OT - machine learning OT - obesity OT - prediction model COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/21 06:32 MHDA- 2026/05/21 06:33 PMCR- 2026/05/05 CRDT- 2026/05/21 04:35 PHST- 2026/02/24 00:00 [received] PHST- 2026/04/16 00:00 [revised] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/05/21 06:33 [medline] PHST- 2026/05/21 06:32 [pubmed] PHST- 2026/05/21 04:35 [entrez] PHST- 2026/05/05 00:00 [pmc-release] AID - 10.3389/fnut.2026.1816724 [doi] PST - epublish SO - Front Nutr. 2026 May 5;13:1816724. doi: 10.3389/fnut.2026.1816724. eCollection 2026. PMID- 42163895 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260521 LR - 20260921 IS - 3067-3534 (Electronic) IS - 3067-3518 (Linking) VI - 1 IP - 2 DP - 2026 Mar-Apr TI - Learning to Breathe with Type 2 Diabetes: A Pilot Feasibility and Acceptability Study of a Mindfulness-Based Intervention in Youth with Type 2 Diabetes or Prediabetes. PG - 211-218 LID - 10.2337/doc25-0047 [doi] AB - OBJECTIVE: Mindfulness-based interventions (MBI) support mental health. We evaluated the feasibility and acceptability of a 12-week MBI in adolescents with obesity and type 2 diabetes or prediabetes. METHODS: This was an uncontrolled, pilot, feasibility and acceptability evaluation in youth aged 15-17 years with type 2 diabetes or prediabetes. The Learning to BREATHE (L2B) curriculum was delivered via 12 virtual group sessions. Recruitment, retention, and attendance were tracked to measure feasibility. Acceptability was measured via post-intervention satisfaction surveys. Questionnaires were administered: pre- and post-intervention, and after 12 months for depression and anxiety symptoms and quality of life (PedsQL()). RESULTS: Sixty-eight of 73 (93%) screened participants were eligible. By design, we enrolled the first 30 eligible participants who agreed and consented to participate. Three (10%) withdrew prior to L2B participation. Twenty-seven completed L2B (90% retention, 18 female; 44% White, 41% Black, 1% Hispanic). The mean attendance was 8 of 12 sessions (67%). Survey completion was 100% pre-L2B, 93% post-L2B, and 81% 12 months post-L2B. Most participants agreed/strongly agreed that they felt supported (80%) and enjoyed the sessions (76%). Baseline depression and anxiety scores were within normal for the population and didn't change from pre- to post-intervention. Immediately following the intervention, the PedsQL() score was higher (65 +/- 20 to 70 +/- 19). Sixteen participants had HbA1c and BMI measures corresponding to all three time points and these were unchanged. CONCLUSION: A 12-week virtual group MBI was feasible and acceptable in adolescents with obesity and type 2 diabetes or prediabetes. FAU - Pike, Julie M AU - Pike JM AD - Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN. FAU - Yorgason, Jessica AU - Yorgason J AD - Kentucky College of Osteopathic Medicine, Pikeville, KY. FAU - Machuca, Luz A AU - Machuca LA AD - Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN. FAU - Broderick, Patricia C AU - Broderick PC AD - Edna Bennett Pierce Prevention Research Center, Pennsylvania State University, University Park, PA. FAU - Hannon, Tamara S AU - Hannon TS AD - Department of Pediatrics, Indiana University School of Medicine, Indianapolis, IN. LA - eng GR - UL1 TR002529/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20260310 PL - United States TA - Diabetes Obes Cardiometab CARE JT - Diabetes, obesity, and cardiometabolic CARE JID - 9919229522706676 PMC - PMC13186448 MID - NIHMS2167959 OTO - NOTNLM OT - adolescent OT - diabetes education OT - mindfulness OT - mindfulness-based intervention OT - obesity OT - prediabetes OT - quality of life OT - type 2 diabetes COIS- Conflict of Interest Patricia Broderick owns the copyright to Learning to BREATHE(R)(c). There are no other relevant conflicts of interest to disclose. EDAT- 2026/05/21 06:33 MHDA- 2026/05/21 06:34 CRDT- 2026/05/21 04:34 PHST- 2026/05/21 06:34 [medline] PHST- 2026/05/21 06:33 [pubmed] PHST- 2026/05/21 04:34 [entrez] AID - 10.2337/doc25-0047 [doi] PST - ppublish SO - Diabetes Obes Cardiometab CARE. 2026 Mar-Apr;1(2):211-218. doi: 10.2337/doc25-0047. Epub 2026 Mar 10. PMID- 42163360 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 2045-709X (Electronic) IS - 2045-709X (Linking) VI - 34 IP - 1 DP - 2026 May 20 TI - The UQTR university-based chiropractic clinic cohort (UQTRChiCo): description and summary of an available data source for research collaborations. LID - 10.1186/s12998-026-00642-2 [doi] LID - 25 AB - BACKGROUND: Musculoskeletal disorders are the leading cause of disability in Canada, and chiropractic care is among the most commonly used healthcare services for their management. Despite this, little is known about the quality of care and adherence to clinical practice guidelines in chiropractic educational settings. This study aimed to describe the Universite du Quebec a Trois-Rivieres university-based chiropractic clinic cohort (UQTRChiCo) and summarize its patient characteristics, care provided, and available outcome data. METHODS: We conducted a retrospective cohort study of patients who first consulted at the Universite du Quebec a Trois-Rivieres (UQTR) chiropractic clinic in 2017, with longitudinal follow-up through 2019. Reasons for clinical consultation (i.e., specific chief complaints) were treated as separate observations. Data were extracted from clinical records and included patient demographics, clinical presentations, care provided, and outcomes measured using validated questionnaires. Follow-up assessments were obtained from re-evaluations conducted at multiple time points between 1 January 2017 and 31 December 2019. RESULTS: The UQTRChiCo comprises 2,148 distinct reasons for consultation from 1,305 unique patients (59% female, mean age 31 +/- 18 years). The most common presentations were lumbar spine (28%), cervical spine (18%), and thoracic spine complaints (10%). Multiple concurrent complaints were reported in 44% of patients, and 43% of conditions were chronic. Care commonly included spinal manipulative therapy (88%) and soft tissue treatments (93%). Patient education and exercise prescription were documented in 67% and 48% of consultations, respectively. Diagnostic imaging was performed in 19% of consultations. Follow-up outcome documentation was available for 58% of consultations at the first re-evaluation, decreasing to 16% by the third re-evaluation. CONCLUSION: The UQTRChiCo provides a comprehensive description of an academic chiropractic clinical population primarily seeking care for spinal musculoskeletal complaints. Care delivery reflected a multimodal approach with restrained use of diagnostic imaging. While short-term outcome monitoring proved feasible, substantial attrition over time underscores a key challenge for longitudinal practice-based research in educational clinics. The UQTRChiCo represents a valuable resource for advancing research on care quality, guideline adherence, and patient outcomes in chiropractic training environments. CI - (c) 2026. The Author(s). FAU - Blanchette, Marc-Andre AU - Blanchette MA AD - Departement chiropratique, Universite du Quebec a Trois-Rivieres, 3351 boul. des Forges, C.P. 500, Trois- Rivieres, QC, G9A 5H7, Canada. marc-andre.blanchette1@uqtr.ca. AD - Departement des sciences de la sante, Universite du Quebec en Abitibi- Temiscamingue (UQAT), Rouyn-Noranda, QC, Canada. marc-andre.blanchette1@uqtr.ca. FAU - Hincapie, Cesar A AU - Hincapie CA AD - Musculoskeletal Epidemiology Research Group-Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich, Zurich, Switzerland. AD - Dalla Lana School of Public Health, University of Toronto, Toronto, Canada. FAU - Theroux, Jean AU - Theroux J AD - CHU Sainte-Justine Research Center, Montreal, QC, Canada. FAU - Guerin, Lisanne AU - Guerin L AD - Departement chiropratique, Universite du Quebec a Trois-Rivieres, 3351 boul. des Forges, C.P. 500, Trois- Rivieres, QC, G9A 5H7, Canada. FAU - Basta, Sandra AU - Basta S AD - Departement chiropratique, Universite du Quebec a Trois-Rivieres, 3351 boul. des Forges, C.P. 500, Trois- Rivieres, QC, G9A 5H7, Canada. FAU - Bezeau, Arianne AU - Bezeau A AD - Departement chiropratique, Universite du Quebec a Trois-Rivieres, 3351 boul. des Forges, C.P. 500, Trois- Rivieres, QC, G9A 5H7, Canada. FAU - Gauthier, Jean-Luc AU - Gauthier JL AD - Departement chiropratique, Universite du Quebec a Trois-Rivieres, 3351 boul. des Forges, C.P. 500, Trois- Rivieres, QC, G9A 5H7, Canada. FAU - Bussieres, Andre AU - Bussieres A AD - Departement chiropratique, Universite du Quebec a Trois-Rivieres, 3351 boul. des Forges, C.P. 500, Trois- Rivieres, QC, G9A 5H7, Canada. AD - Faculty of Medicine and Health Sciences, McGill University, Montreal, QC, Canada. LA - eng PT - Journal Article DEP - 20260520 PL - England TA - Chiropr Man Therap JT - Chiropractic & manual therapies JID - 101551481 SB - IM MH - Humans MH - Female MH - Male MH - Retrospective Studies MH - Adult MH - *Musculoskeletal Diseases/therapy/epidemiology MH - Quebec MH - *Chiropractic/statistics & numerical data MH - Middle Aged MH - *Manipulation, Chiropractic/statistics & numerical data MH - Young Adult MH - Adolescent MH - Referral and Consultation MH - Aged PMC - PMC13366984 OTO - NOTNLM OT - Academic clinic cohort OT - Cata resource OT - Chiropractic education OT - Clinical practice guidelines OT - Musculoskeletal disorders OT - Quality of care COIS- Declarations. Ethics approval and consent to participate: This study received ethics approval from the UQTR Research Ethics Board (CER-20-266-07.05) and complies with all applicable privacy and data protection regulations. Use of artificial intelligence tools: During the preparation of this manuscript, the authors used Claude Sonnet 4.6 (Anthropic, 2026) to assist with text editing and language refinement. All content was subsequently reviewed and verified by the authors, who take full responsibility for the accuracy and integrity of the published work. Competing interests: MAB has received research grants from: Canadian Chiropractic Research foundation (CCRF), Fondation Chiropratique du Quebec (FCQ), Association des chiropraticiens du Quebec (ACQ), Ordre des chiropraticiens du Quebec, and Fondation de l'Universite du Quebec a Trois-Rivieres. MAB has also received speaker honorarium from the Canadian Chiropractic Association, OCQ and ACQ. CAH reports grants from the Swiss National Science Foundation (SNSF) and the European Centre for Chiropractic Research Excellence (ECCRE) outside the submitted work. All the other authors report no conflict of interest. EDAT- 2026/05/21 06:31 MHDA- 2026/07/14 16:10 PMCR- 2026/05/20 CRDT- 2026/05/21 01:12 PHST- 2025/11/01 00:00 [received] PHST- 2026/04/07 00:00 [accepted] PHST- 2026/07/14 16:10 [medline] PHST- 2026/05/21 06:31 [pubmed] PHST- 2026/05/21 01:12 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - 10.1186/s12998-026-00642-2 [pii] AID - 642 [pii] AID - 10.1186/s12998-026-00642-2 [doi] PST - epublish SO - Chiropr Man Therap. 2026 May 20;34(1):25. doi: 10.1186/s12998-026-00642-2. PMID- 42163356 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260825 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 23 IP - 1 DP - 2026 May 20 TI - Effect of parent-focused interventions for screen use on developmental outcomes in young children: a systematic review and meta-analysis. LID - 10.1186/s12966-026-01919-8 [doi] LID - 71 AB - INTRODUCTION: Parents are a key target for interventions promoting healthy screen use in young children, but no review has evaluated the effect of such parent-focused interventions on developmental outcomes in early childhood. The objective of this study was to conduct a systematic review and meta-analyses of the effects of parent-focused interventions for screen use on young children's social-emotional, cognitive, and physical development, as well as proximal indicators of development including sleep and physical activity. A secondary objective was to assess their impact on children's screen use. METHODS: Eight databases were searched with publication dates between 2007 and March 2025. Randomised controlled trials of parent-focused interventions targeting screen use in children (birth-5.99 years) were included if they reported outcomes related to both child screen use and development. Stata was used to undertake meta-analyses using multilevel random effects models to estimate effects for outcomes with data from at least three papers. RESULTS: In total, 10 studies (11 papers) were eligible for inclusion, with eight studies (n = 1,776 participants) providing sufficient data to be included in meta-analyses of at least one outcome. Interventions targeted screen use duration (n = 8 studies), screen use before bed (n = 1 study) and screen content (n = 1 study; 2 papers). Interventions achieved reductions in social-emotional problems (ES=-0.32 (95%CI:-0.51,-0.12)), externalizing behaviors (ES=-0.31 (95%CI:-0.56,-0.05)) and screen time (ES=-0.92 (95%CI:-1.66,-0.18)). Few interventions (n = 2) targeted aspects of screen use other than duration (e.g. content quality and timing). Larger effects were achieved for interventions that were underpinned by a theory and incorporated a range of established behavior change techniques, compared to interventions that did not incorporate these aspects. Few studies explored intervention effects on physical activity, body mass index, cognitive development and/or motor skills, and heterogenous sleep outcomes were reported, making it difficult to draw definitive conclusions regarding these outcomes. CONCLUSIONS: Few parent-focused interventions for screen use were identified and most targeted screen use duration. Future intervention studies may consider targeting aspects of screen use other than duration (e.g. content quality), and evaluating their feasibility and acceptability for parents, compared to interventions targeting screen use duration. The protocol was prospectively registered on PROSPERO (ID: CRD420250654905). CI - (c) 2026. The Author(s). FAU - Machell, Amanda AU - Machell A AD - Institute for Physical Activity and Nutrition (IPAN), Deakin University, Geelong, VIC, Australia. a.machell@deakin.edu.au. FAU - Ewin, Carrie AU - Ewin C AD - School of Psychology, Deakin University, Geelong, VIC, Australia. FAU - Horwood, Sharon AU - Horwood S AD - School of Psychology, Deakin University, Geelong, VIC, Australia. FAU - Downing, Katherine L AU - Downing KL AD - Institute for Physical Activity and Nutrition (IPAN), Deakin University, Geelong, VIC, Australia. FAU - Hesketh, Kylie D AU - Hesketh KD AD - Institute for Physical Activity and Nutrition (IPAN), Deakin University, Geelong, VIC, Australia. LA - eng GR - 105929/National Heart Foundation of Australia/ PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260520 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - *Screen Time MH - *Child Development MH - Child, Preschool MH - *Parents MH - Infant MH - Exercise MH - Randomized Controlled Trials as Topic MH - Sleep MH - Cognition MH - *Health Promotion/methods PMC - PMC13374355 OTO - NOTNLM OT - Cognitive development OT - Early childhood OT - Physical development. OT - Screen context OT - Social-emotional development COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/21 06:33 MHDA- 2026/07/17 19:17 PMCR- 2026/05/20 CRDT- 2026/05/21 01:12 PHST- 2025/10/30 00:00 [received] PHST- 2026/04/12 00:00 [accepted] PHST- 2026/07/17 19:17 [medline] PHST- 2026/05/21 06:33 [pubmed] PHST- 2026/05/21 01:12 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - 10.1186/s12966-026-01919-8 [pii] AID - 1919 [pii] AID - 10.1186/s12966-026-01919-8 [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2026 May 20;23(1):71. doi: 10.1186/s12966-026-01919-8. PMID- 42163318 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260714 LR - 20260813 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2026 May 20 TI - Psychometric properties of the Night Eating Questionnaire (NEQ) in a clinical sample of Turkish adolescents. LID - 10.1186/s40337-026-01633-7 [doi] LID - 160 AB - BACKGROUND: This study aimed to examine the psychometric properties of the Turkish version of the Night Eating Questionnaire (NEQ) in an adolescent clinical sample. METHODS: The sample consisted of 267 adolescents aged 13-17 years (64.8% girls; mean age = 15.23 +/- 1.29 years) recruited from child and adolescent psychiatry outpatient clinics of two university hospitals in Turkiye. The NEQ, Eating Attitudes Test-26 (EAT-26), Revised Child Anxiety and Depression Scale - Child Version (RCADS-CV), and Sleep Quality Scale and Sleep Variables Questionnaire (SQS-SVQ) were administered. Exploratory factor analysis (EFA), confirmatory factor analysis (CFA), internal consistency, and convergent validity were examined. RESULTS: EFA identified a four-factor structure accounting for 62.39% of the total variance, consistent with the original factor solution. CFA supported the four-factor structure of the NEQ (CMIN/df = 1.606, RMSEA = 0.048, CFI = 0.964, TLI = 0.951), consisting of nocturnal ingestions, evening hyperphagia, morning anorexia, and mood/sleep disturbances. Internal consistency was acceptable for the total scale (Cronbach's alpha = 0.73). The NEQ demonstrated meaningful convergent validity through significant positive correlations with sleep quality, anxiety, depression, and disordered eating attitudes. Adolescents in the overweight group reported significantly higher NEQ total scores, particularly on the evening hyperphagia and mood/sleep disturbances subscales. Girls showed higher scores on morning anorexia and mood/sleep disturbances compared with boys. CONCLUSIONS: The Turkish NEQ demonstrated satisfactory psychometric properties in an adolescent clinical sample and appears to be a valid and reliable instrument for assessing night eating symptoms in Turkish adolescent clinical populations. CI - (c) 2026. The Author(s). FAU - Akinci, Mehmet Akif AU - Akinci MA AUID- ORCID: 0000-0002-6436-4394 AD - Department of Child and Adolescent Psychiatry, Ataturk University, Erzurum, Turkiye. akinci_mehmetakif@hotmail.com. FAU - Turan, Bahadir AU - Turan B AUID- ORCID: 0000-0003-1190-9589 AD - Department of Child and Adolescent Psychiatry, Karadeniz Technical University, Trabzon, Turkiye. AD - Cambridgeshire and Peterborough NHS Foundation Trust, Cambridge, UK. FAU - Bayindir, Kubra AU - Bayindir K AUID- ORCID: 0009-0004-6558-3515 AD - Department of Child and Adolescent Psychiatry, Ataturk University, Erzurum, Turkiye. FAU - Tuzcu, Furkan Can AU - Tuzcu FC AUID- ORCID: 0009-0008-3173-9429 AD - Department of Child and Adolescent Psychiatry, Karadeniz Technical University, Trabzon, Turkiye. FAU - Yildirim Demirdogen, Esen AU - Yildirim Demirdogen E AUID- ORCID: 0000-0002-2457-5832 AD - Department of Child and Adolescent Psychiatry, Ataturk University, Erzurum, Turkiye. FAU - Bozkurt, Abdullah AU - Bozkurt A AUID- ORCID: 0000-0002-8359-6131 AD - Department of Child and Adolescent Psychiatry, Ataturk University, Erzurum, Turkiye. LA - eng PT - Journal Article DEP - 20260520 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC13366900 OAB - Night Eating Syndrome (NES) is a condition in which people eat a large portion of their daily food late in the evening or during the night. To better understand and identify these behaviors, researchers often use questionnaires that measure the severity of night eating symptoms. In this study, we examined whether the Turkish version of the Night Eating Questionnaire (NEQ) is a reliable and useful tool for assessing night eating behaviors in adolescents. A total of 267 adolescents aged 13-17 years who were receiving care at child and adolescent psychiatry clinics participated in the study. They completed the NEQ along with several questionnaires about eating habits, sleep quality, and emotional well-being. Our findings showed that the Turkish NEQ works well in adolescents and can reliably measure different aspects of night eating, such as eating during the night, eating large amounts in the evening, loss of appetite in the morning, and sleep or mood-related difficulties. We also found that adolescents with higher body weight tended to report more severe night eating symptoms, and girls reported more sleep- and mood-related symptoms than boys. These results suggest that the NEQ can help clinicians identify night eating symptoms in adolescents and may support earlier recognition of eating-related problems in young people. OABL- eng OTO - NOTNLM OT - Adolescents OT - Night Eating Questionnaire OT - Night eating syndrome OT - Psychometric properties OT - Reliability OT - Validity COIS- Declarations. Ethics approval and consent to participate: Ethical committee approval was received from the Research Ethics Committee (REC) of Ataturk University (approval no: B.30.2.ATA.0.01.00/33; date: 21.02.2024). The study procedures were conducted in accordance with the principles of the Declaration of Helsinki. Written informed consent was obtained from all the participants and their parents. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/21 06:31 MHDA- 2026/05/21 06:32 PMCR- 2026/05/20 CRDT- 2026/05/21 01:10 PHST- 2026/03/13 00:00 [received] PHST- 2026/05/01 00:00 [accepted] PHST- 2026/05/21 06:32 [medline] PHST- 2026/05/21 06:31 [pubmed] PHST- 2026/05/21 01:10 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - 10.1186/s40337-026-01633-7 [pii] AID - 1633 [pii] AID - 10.1186/s40337-026-01633-7 [doi] PST - epublish SO - J Eat Disord. 2026 May 20;14(1):160. doi: 10.1186/s40337-026-01633-7. PMID- 42163093 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20261012 IS - 1471-2253 (Electronic) IS - 1471-2253 (Linking) VI - 26 IP - 1 DP - 2026 May 20 TI - Predictors of early extubation after pediatric liver transplantation: a single-center retrospective cohort study. LID - 10.1186/s12871-026-03915-8 [doi] LID - 421 AB - BACKGROUND: Liver transplantation is a cornerstone therapy for pediatric end-stage liver disease. While Enhanced Recovery After Surgery (ERAS) protocols, including early extubation, are well-established in adult liver transplantation, their application in children is more cautious due to unique challenges like malnutrition and poor postoperative cooperation. This study aimed to identify predictors of successful early extubation (within 3 h postoperatively) in pediatric liver transplant recipients. METHODS: This was a single-center retrospective cohort study. We analyzed data from 256 patients under 18 years who underwent liver transplantation between September 2019 and November 2022. Patients were divided into Early Extubation (EE, 3 h) groups. Univariate and multivariate logistic regression analyses were performed to identify factors associated with EE. The efficacy of relevant parameters in predicting early extubation was evaluated using receiver operating characteristic (ROC) curve analysis. RESULTS: Of the 256 patients, 155 (61%) were successfully extubated early. Multivariate analysis identified the following independent predictors: favorable factors were higher preoperative albumin (ALB) level (adjusted OR 1.167, p = 0.008) and greater intraoperative urine output (adjusted OR 4.686, p < 0.001); unfavorable factors were higher preoperative white blood cell (WBC) count (adjusted OR 0.806, p = 0.038), higher end-of-surgery serum lactate level (adjusted OR 0.548, p < 0.001), presence of a concurrent respiratory tract infection (adjusted OR 0.307, p = 0.021), and receiving a donation after circulatory death (DCD) graft (adjusted OR 0.260, p = 0.030). ROC curve analysis identified optimal cutoff values for predicting early extubation: total urine output showed strong discriminative ability (AUC 0.898, 95% CI 0.859-0.938, sensitivity 79.4%, specificity 88.1%); EOS serum lactate showed moderate discriminative ability (AUC 0.725, 95% CI 0.659-0.791, sensitivity 49.5%, specificity 91.0%); pre-op ALB and pre-op WBC showed modest discriminative ability (AUC 0.663 and 0.623, respectively). Optimal cutoff values were: pre-op ALB >/= 36.15 g/L, pre-op WBC /= 3.05 mL/kg/h, and EOS lactate /= 85 years) is steadily increasing. Despite their vulnerability, the existing evidence base for prophylaxis is heavily derived from younger populations, creating a significant extrapolation gap. Current guidelines for the prevention of Post-ERCP pancreatitis (PEP) advocate for universal measures-such as aggressive hydration and rectal nonsteroidal anti-inflammatory drugs-based on trials that frequently exclude frail patients with significant comorbidities. This perspective piece challenges the "one-size-fits-all" application of these protocols in the geriatric demographic, proposing a hypothetical clinical practice approach. We conducted a targeted review of peer-reviewed literature focusing on the pathophysiology of the aging pancreas and the safety of prophylactic interventions. Key findings reveal a "risk-outcome dissociation": while pancreatic senescence biologically lowers PEP incidence, frailty increases mortality when it occurs. Regarding fluid management, we propose a hypothesis-driven, restrictive hydration rate of 1.7 mL/kg/h without a bolus for patients with heart failure. This rate is physiologically grounded (adapted from the Holliday-Segar pediatric maintenance formula for the altered body composition of the elderly) to provide "enhanced maintenance" to cover fasting deficits while avoiding the volume surge (>/= 3 mL/kg/h) that precipitates pulmonary edema in non-compliant ventricles. Treating the elderly requires a paradigm shift to "Precision Geriatric Endoscopy", utilizing biomarker-driven triage and bedside frailty tools. Most critically, this proposed protocol represents a pathophysiological hypothesis and framework rather than established evidence. Future prospective randomized controlled trials are urgently needed to validate this approach. CI - (c) 2026 Japan Geriatrics Society. FAU - Takahashi, Koji AU - Takahashi K AUID- ORCID: 0000-0001-8134-8524 AD - Department of Gastroenterology, Eastern Chiba Medical Center, Togane, Japan. AD - Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Japan. FAU - Yamada, Nana AU - Yamada N AD - Department of Gastroenterology, Eastern Chiba Medical Center, Togane, Japan. AD - Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Japan. FAU - Iwanaga, Terunao AU - Iwanaga T AD - Department of Gastroenterology, Eastern Chiba Medical Center, Togane, Japan. AD - Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Japan. FAU - Sakuma, Takafumi AU - Sakuma T AD - Department of Gastroenterology, Eastern Chiba Medical Center, Togane, Japan. AD - Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Japan. FAU - Kamezaki, Hidehiro AU - Kamezaki H AUID- ORCID: 0000-0003-2238-9558 AD - Department of Gastroenterology, Eastern Chiba Medical Center, Togane, Japan. AD - Department of General Medical Science, Graduate School of Medicine, Chiba University, Chiba, Japan. LA - eng PT - Journal Article PT - Review PL - Japan TA - Geriatr Gerontol Int JT - Geriatrics & gerontology international JID - 101135738 SB - IM MH - Humans MH - *Cholangiopancreatography, Endoscopic Retrograde/adverse effects MH - *Pancreatitis/etiology/prevention & control/epidemiology MH - Aged, 80 and over MH - *Postoperative Complications/prevention & control OTO - NOTNLM OT - BNP OT - NSAIDs OT - POCUS OT - elderly OT - frailty OT - hydration OT - post-ERCP pancreatitis EDAT- 2026/05/21 05:33 MHDA- 2026/05/21 05:34 CRDT- 2026/05/20 20:02 PHST- 2026/05/03 00:00 [revised] PHST- 2026/03/24 00:00 [received] PHST- 2026/05/14 00:00 [accepted] PHST- 2026/05/21 05:34 [medline] PHST- 2026/05/21 05:33 [pubmed] PHST- 2026/05/20 20:02 [entrez] AID - 10.1111/ggi.70548 [doi] PST - ppublish SO - Geriatr Gerontol Int. 2026 May;26(5):e70548. doi: 10.1111/ggi.70548. PMID- 42161005 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260717 IS - 1873-7358 (Electronic) IS - 1471-0153 (Linking) VI - 61 DP - 2026 Apr TI - Validation and measurement invariance of the Intuitive Eating Scale-3 among Brazilian adolescents. PG - 102093 LID - S1471-0153(26)00026-7 [pii] LID - 10.1016/j.eatbeh.2026.102093 [doi] AB - Intuitive eating is an evidence-based, non-diet approach to nutrition that heals individuals' relationship with food by listening to internal body cues rather than external rules. The Intuitive Eating Scale is a widely used measure that has been validated across diverse cultural contexts and among individuals of different sociocultural backgrounds. However, its third version (IES-3) is not available for adolescents, an at-risk population for eating disorders and body image disturbances. In the present study, we perform the validation of the IES-3 in a sample of 295 Brazilian adolescents. Confirmatory factor analysis (CFA) and exploratory structural equation modeling (ESEM) supported the original four-factor structure of the measure, after excluding IES-3 Item #6. Bifactor CFA support a global scale score. Full measurement invariance was found between male and female adolescents. Additionally, we found good convergent validity with measures of emotional eating, external eating, restrained eating, body acceptance by others, body appreciation, and body dissatisfaction. Finally, we found good internal consistency for IES-3 total scores and two subscales. Results support the use of the measure in Brazilian adolescents, allowing for future studies on eating disorder prevention and intervention. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - de Fialho, Daena Cunha AU - de Fialho DC AD - Body Image and Eating Disorders Research Group (NICTA), Federal University of Juiz de Fora, Governador Valadares, Brazil. Electronic address: daena.cunha@estudante.ufjf.br. FAU - Tylka, Tracy L AU - Tylka TL AD - Department of Psychology, Ohio State University, United States. Electronic address: tylka.2@osu.edu. FAU - Resende, Thaina Richelli Oliveira AU - Resende TRO AD - Body Image and Eating Disorders Research Group (NICTA), Federal University of Juiz de Fora, Governador Valadares, Brazil. Electronic address: thaina.richelli@gmail.com. FAU - da Silva, Wanderson Roberto AU - da Silva WR AD - Eating Disorders Program, Institute of Psychiatry (AMBULIM), University of Sao Paulo, Sao Paulo, Brazil. Electronic address: wandersonroberto22@gmail.com. FAU - Alvarenga, Marle Dos Santos AU - Alvarenga MDS AD - Post-graduation Program in Public Health Nutrition, School of Public Health, University of Sao Paulo, Brazil. Electronic address: marlealvarenga@gmail.com. FAU - de Carvalho, Pedro Henrique Berbert AU - de Carvalho PHB AD - Body Image and Eating Disorders Research Group (NICTA), Federal University of Juiz de Fora, Governador Valadares, Brazil; Eating Disorders Program, Institute of Psychiatry (AMBULIM), University of Sao Paulo, Sao Paulo, Brazil. Electronic address: pedro.berbert@ufjf.br. LA - eng PT - Journal Article PT - Validation Study DEP - 20260518 PL - United States TA - Eat Behav JT - Eating behaviors JID - 101090048 SB - IM MH - Humans MH - Adolescent MH - Female MH - Brazil MH - Male MH - Psychometrics MH - Reproducibility of Results MH - *Body Image/psychology MH - *Feeding Behavior/psychology MH - Factor Analysis, Statistical MH - *Feeding and Eating Disorders/psychology/diagnosis MH - Surveys and Questionnaires MH - Body Satisfaction MH - Body Dissatisfaction/psychology MH - *Intuition MH - Emotional Eating OTO - NOTNLM OT - Body acceptance OT - Body appreciation OT - Body dissatisfaction OT - Disordered eating OT - Intuitive eating OT - Measurement OT - Psychometrics COIS- Declaration of competing interest The authors have no conflicts of interest to declare that are relevant to the content of this article. EDAT- 2026/05/21 05:33 MHDA- 2026/05/29 15:45 CRDT- 2026/05/20 18:07 PHST- 2026/03/21 00:00 [received] PHST- 2026/05/13 00:00 [revised] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/05/29 15:45 [medline] PHST- 2026/05/21 05:33 [pubmed] PHST- 2026/05/20 18:07 [entrez] AID - S1471-0153(26)00026-7 [pii] AID - 10.1016/j.eatbeh.2026.102093 [doi] PST - ppublish SO - Eat Behav. 2026 Apr;61:102093. doi: 10.1016/j.eatbeh.2026.102093. Epub 2026 May 18. PMID- 42160824 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260611 IS - 1873-491X (Electronic) IS - 0020-7489 (Linking) VI - 181 DP - 2026 Sep TI - Tailored profiles of physical activity in children with asthma: Insights from a mixed methods study. PG - 105575 LID - S0020-7489(26)00247-6 [pii] LID - 10.1016/j.ijnurstu.2026.105575 [doi] AB - BACKGROUND: Physical activity participation among children with asthma is highly variable and cannot be explained by disease severity alone. Understanding distinct patterns of activity engagement and their underlying mechanisms may help inform more tailored support strategies. OBJECTIVE: To identify distinct physical activity profiles in children with asthma and to explore the lived experiences and family processes underlying these profiles using a mixed-methods design. METHODS: An explanatory sequential mixed-methods study was conducted in two phases. In the quantitative phase, 243 children with asthma aged 6-17 years were consecutively recruited between March 2024 and February 2025 from respiratory outpatient clinics of two tertiary hospitals in Zhejiang Province, China. Measures assessed physical activity, asthma control, breathlessness-related fear, perceived physical competence, and parental activity support. Person-centered profile modeling was used to identify distinct profiles. In the qualitative phase, 16 child-parent dyads (4 per profile) were purposively selected for semi-structured interviews between June and September 2025. Joint display analysis was used to integrate quantitative patterns with lived experiences. RESULTS: Four distinct profiles were identified. Profile 1, Fearful Avoiders (14.4%), showed the lowest activity, poorest asthma control, highest symptom fear, and lowest physical competence; qualitative findings suggested a self-reinforcing cycle of fear, avoidance, and reduced confidence. Profile 2, Unsupported Potentials (15.6%), showed predominantly moderate activity, the lowest parental support, and predominantly partial asthma control; interviews suggested that symptom stability was often interpreted as "good enough," leading families to disengage from active lifestyle support. Profile 3, Struggling Strivers (21.4%), maintained moderate activity despite elevated symptom fear and intermediate psychosocial outcomes; qualitative data suggested that activity was often sustained under peer and family pressure rather than through genuine confidence. Profile 4, Supported Thrivers (48.6%), demonstrated the most favorable pattern, with higher activity, better asthma control, lower fear, stronger perceived competence, and greater parental support. External validation supported the clinical relevance of the profiles, with significant between-profile differences in depression, anxiety, quality of life, and exercise adherence (all p < .001). CONCLUSION: Physical activity participation in children with asthma appears to be shaped by interacting physiological, psychological, and family processes rather than by disease severity alone. Similar activity levels may reflect very different underlying mechanisms, including disengagement, fear-driven persistence, or adaptive self-management. These findings suggest that support for physical activity in pediatric asthma may need to be tailored to profile-specific behavioral and family mechanisms. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Lin, Nan AU - Lin N AD - Department of Nursing, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang, China. FAU - Sun, Ye AU - Sun Y AD - Department of Nursing, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang, China. FAU - Jin, Jingyi AU - Jin J AD - Department of Neonatal Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang, China. FAU - Lai, Dengming AU - Lai D AD - Department of Neonatal Surgery, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang, China. Electronic address: dengming_lai@zju.edu.cn. FAU - Chen, Zhimin AU - Chen Z AD - Department of Pulmonology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang, China. Electronic address: zmchen@zju.edu.cn. FAU - Xu, Hongzhen AU - Xu H AD - Department of Nursing, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, Zhejiang, China. Electronic address: 6184020@zju.edu.cn. LA - eng PT - Journal Article DEP - 20260520 PL - England TA - Int J Nurs Stud JT - International journal of nursing studies JID - 0400675 SB - IM MH - Humans MH - Child MH - *Asthma/physiopathology/psychology MH - Adolescent MH - Male MH - *Exercise MH - Female OTO - NOTNLM OT - Asthma OT - Children OT - Family support OT - Mixed-methods research OT - Person-centered profiles OT - Physical activity COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Hongzhen Xu reports article publishing charges was provided by Zhejiang University School of Medicine Children's Hospital. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/21 05:33 MHDA- 2026/06/11 18:35 CRDT- 2026/05/20 18:02 PHST- 2026/01/06 00:00 [received] PHST- 2026/05/05 00:00 [revised] PHST- 2026/05/10 00:00 [accepted] PHST- 2026/06/11 18:35 [medline] PHST- 2026/05/21 05:33 [pubmed] PHST- 2026/05/20 18:02 [entrez] AID - S0020-7489(26)00247-6 [pii] AID - 10.1016/j.ijnurstu.2026.105575 [doi] PST - ppublish SO - Int J Nurs Stud. 2026 Sep;181:105575. doi: 10.1016/j.ijnurstu.2026.105575. Epub 2026 May 20. PMID- 42160790 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260914 IS - 1872-6976 (Electronic) IS - 0167-4943 (Linking) VI - 149 DP - 2026 Oct TI - Development and validation of a GDF-15-albumin-CRP score for predicting Cachexia in Asian patients with decompensated cirrhosis. PG - 106305 LID - S0167-4943(26)00175-5 [pii] LID - 10.1016/j.archger.2026.106305 [doi] AB - BACKGROUND & AIMS: Cachexia is prevalent and prognostically adverse in decompensated cirrhosis. Diagnosis is challenging, especially in Asian populations, due to limitations of current criteria and scoring systems. This study aimed to develop and validate a biomarker-based model for predicting cachexia defined by the Asian Working Group for Cachexia (AWGC) in cirrhotic patients. METHODS: In this retrospective cohort study, 420 patients with decompensated cirrhosis were enrolled (295 in the training cohort, 125 in the external validation cohort). Cachexia was diagnosed according to AWGC criteria. LASSO regression selected predictive serum biomarkers. A nomogram-derived GDF-15-Albumin-CRP score was constructed, and its performance was evaluated using the area under the receiver operating characteristic curve (AUC), calibration, and decision curve analysis (DCA). RESULTS: In the training cohort, 158 patients (53.56%) had cachexia. LASSO regression identified serum growth differentiation factor-15 (GDF-15), albumin, and C-reactive protein (CRP) as the strongest predictors. The resulting GDF-15-Albumin-CRP score achieved an AUC of 0.736 (95% CI: 0.680-0.792) for cachexia prediction, significantly outperforming Child-Turcotte-Pugh (CTP), Model for End-Stage Liver Disease (MELD), and MELD-Na scores (all P < 0.05). DCA demonstrated clinical net benefit across a wide range of threshold probabilities. The score exhibited a strong risk gradient for cachexia (adjusted OR for the high- vs. low-risk group: 7.58; 95% CI: 2.68-21.46). External validation confirmed its performance (AUC = 0.723, 95% CI: 0.630-0.810). CONCLUSIONS: The GDF-15-Albumin-CRP score is a validated and clinically feasible tool predicting AWGC-defined cachexia in Asian cirrhotic patients, superior to traditional severity scores and potentially enabling earlier targeted intervention. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Yao, Shuangzhe AU - Yao S AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin, China. FAU - Peng, Binbin AU - Peng B AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin, China. FAU - Ren, Lingyu AU - Ren L AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin, China. FAU - Yang, Ziyi AU - Yang Z AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin, China. FAU - Jiang, Kui AU - Jiang K AD - Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Anshan Road 154, Heping District, Tianjin, China. Electronic address: kjiang@tmu.edu.cn. FAU - Sun, Chao AU - Sun C AD - Department of Gastroenterology, The First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi, 710077, China. Electronic address: chaosun@tmu.edu.cn. LA - eng PT - Journal Article PT - Validation Study DEP - 20260516 PL - Netherlands TA - Arch Gerontol Geriatr JT - Archives of gerontology and geriatrics JID - 8214379 RN - 0 (Growth Differentiation Factor 15) RN - 9007-41-4 (C-Reactive Protein) RN - 0 (Biomarkers) RN - 0 (GDF15 protein, human) RN - 0 (Serum Albumin) SB - IM MH - Humans MH - Female MH - *Liver Cirrhosis/complications/blood MH - Retrospective Studies MH - *Growth Differentiation Factor 15/blood MH - Male MH - *Cachexia/diagnosis/etiology/blood MH - *C-Reactive Protein/analysis/metabolism MH - Middle Aged MH - Biomarkers/blood MH - Aged MH - *Serum Albumin/analysis MH - Predictive Value of Tests MH - ROC Curve MH - Prognosis MH - Asian People OTO - NOTNLM OT - AWGC consensus OT - Cachexia OT - Growth differentiation factor-15 OT - Liver cirrhosis OT - Predictive model COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/20 18:33 MHDA- 2026/06/12 18:41 CRDT- 2026/05/20 18:00 PHST- 2026/03/17 00:00 [received] PHST- 2026/05/09 00:00 [revised] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/06/12 18:41 [medline] PHST- 2026/05/20 18:33 [pubmed] PHST- 2026/05/20 18:00 [entrez] AID - S0167-4943(26)00175-5 [pii] AID - 10.1016/j.archger.2026.106305 [doi] PST - ppublish SO - Arch Gerontol Geriatr. 2026 Oct;149:106305. doi: 10.1016/j.archger.2026.106305. Epub 2026 May 16. PMID- 42160712 OWN - NLM STAT- Publisher LR - 20260520 IS - 1529-4242 (Electronic) IS - 0032-1052 (Linking) DP - 2026 May 20 TI - "Comparative Effectiveness of PLANA and Nasal Elevator in Presurgical Orthopedics: A 3D Anthropometric Study of Unilateral Cleft Lip.". LID - 10.1097/PRS.0000000000013220 [doi] AB - BACKGROUND: As limitations of nasoalveolar molding (NAM), including labor intensity and reliance on specialized expertise and infrastructure, have become increasingly evident, interest has shifted toward simplified presurgical infant orthopedics (PSIO). Nasal Elevator (NE)-based protocols and the recently introduced Presurgical Lip-Alveolus-Nose Approximation (PLANA) represent such alternatives. However, these two simplified approaches have not been directly compared using objective three-dimensional analysis and a validated anthropometric grading system. This study compared NE-based PSIO and PLANA in infants with unilateral cleft lip. METHODS: Consecutive cohorts of 26 infants treated with NE (2023-2024) and 23 infants treated with PLANA (2024-2025) were analyzed; all PSIO was performed by the same surgeon. Cleft severity (four levels) and PSIO outcomes (Excellent/Good/Poor) were assessed using a validated anthropometric grading system based on nostril width ratio (NWR), columellar angle (CA), and subnasale lateral displacement (SN). Groups were compared using Fisher's exact test, chi-square testing, and Mann-Whitney U test (p < 0.05). RESULTS: Baseline characteristics were comparable between groups. PLANA achieved a more favorable post-PSIO severity distribution (p = 0.049) and a higher proportion of Excellent outcomes with fewer Poor outcomes (chi(2) = 7.48, p = 0.024). Improvement in SN was significantly greater with PLANA (p = 0.04), whereas improvements in NWR and CA were comparable between techniques. CONCLUSIONS: Both NE-based PSIO and PLANA improved nasolabial morphology in unilateral cleft lip. However, PLANA demonstrated superior presurgical orthopedic effectiveness, particularly in subnasale alignment, supporting its role as an effective and scalable PSIO strategy. CI - Copyright (c) 2026 by the American Society of Plastic Surgeons. FAU - Tanikawa, Daniela Y S AU - Tanikawa DYS AD - . Cleft Lip and Palate Team, Menino Jesus Municipal Hospital; Cleft Lip and Palate Center, Sabara Children's Hospital; Smile Train's Latin America Medical Advisory Council; Sao Paulo, Brazil. FAU - Figueroa, Alvaro A AU - Figueroa AA AD - . Figueroa Orthodontics; Smile Train's Global Medical Advisory Board; Winnetka, Illinois, United States. LA - eng PT - Journal Article DEP - 20260520 PL - United States TA - Plast Reconstr Surg JT - Plastic and reconstructive surgery JID - 1306050 SB - IM EDAT- 2026/05/20 18:33 MHDA- 2026/05/20 18:33 CRDT- 2026/05/20 16:13 PHST- 2026/05/20 18:33 [medline] PHST- 2026/05/20 18:33 [pubmed] PHST- 2026/05/20 16:13 [entrez] AID - 00006534-990000000-03280 [pii] AID - 10.1097/PRS.0000000000013220 [doi] PST - aheadofprint SO - Plast Reconstr Surg. 2026 May 20. doi: 10.1097/PRS.0000000000013220. PMID- 42160200 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260802 IS - 1532-7914 (Electronic) IS - 0163-5581 (Linking) VI - 78 IP - 6 DP - 2026 TI - Treatment-Associated Changes in Taste Perception and PROP Bitterness Responsiveness in Children with Solid Tumors: Associations with Gastrointestinal Symptoms and Nutritional Risk. PG - 435-443 LID - 10.1080/01635581.2026.2674928 [doi] AB - Taste dysfunction is increasingly recognized as a treatment-related adverse effect in pediatric oncology and may contribute to nutritional vulnerability. This prospective longitudinal study evaluated 60 children aged 8-18 years with solid tumors at an early-treatment baseline, defined as within the first month after diagnosis and following completion of the first chemotherapy cycle, and during treatment at months 2 and 4. Twenty healthy peers served as baseline controls. Self-reported taste alterations were assessed using a validated self-report instrument, and gastrointestinal symptoms and nutritional risk were evaluated using standardized scales. Subjective taste alterations increased during therapy, while objective PROP testing indicated progressively reduced bitterness responsiveness. Gastrointestinal symptom burden also increased significantly over time. Nutritional risk scores were positively correlated with both gastrointestinal symptom severity (r = 0.30-0.42, p < 0.05) and taste alteration scores (r = 0.28-0.43, p < 0.05). Children receiving multimodal treatment tended to exhibit more pronounced sensory alterations and higher nutritional risk. These findings suggest that treatment-associated taste changes co-occur with greater gastrointestinal symptom burden and higher nutritional risk in children with solid tumors. Longitudinal assessment of sensory changes may help identify patients at increased nutritional vulnerability during oncological therapy. FAU - Misirlioglu, Penbe Ecem AU - Misirlioglu PE AD - Department of Nutrition and Dietetics, Avrasya University, Trabzon, Turkiye. FAU - Kose, Beril AU - Kose B AD - Department of Nutrition and Dietetics, Baskent University, Ankara, Turkiye. FAU - Kantar, Mehmet AU - Kantar M AD - Department of Pediatric Oncology, Ege University Faculty of Medicine, Tulay Aktas Oncology Hospital, Izmir, Turkiye. FAU - Hopanci Bicakli, Derya AU - Hopanci Bicakli D AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Mugla Sitki Kocman University, Mugla, Turkiye. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260520 PL - United States TA - Nutr Cancer JT - Nutrition and cancer JID - 7905040 RN - 0 (Antineoplastic Agents) SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Adolescent MH - Prospective Studies MH - Longitudinal Studies MH - *Neoplasms/drug therapy/therapy MH - *Taste Perception/drug effects MH - *Taste Disorders/chemically induced/etiology MH - *Gastrointestinal Diseases/etiology/chemically induced MH - Nutritional Status MH - *Taste/drug effects MH - *Antineoplastic Agents/adverse effects EDAT- 2026/05/20 18:33 MHDA- 2026/05/28 00:30 CRDT- 2026/05/20 12:53 PHST- 2026/05/28 00:30 [medline] PHST- 2026/05/20 18:33 [pubmed] PHST- 2026/05/20 12:53 [entrez] AID - 10.1080/01635581.2026.2674928 [doi] PST - ppublish SO - Nutr Cancer. 2026;78(6):435-443. doi: 10.1080/01635581.2026.2674928. Epub 2026 May 20. PMID- 42159937 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2509-9280 (Electronic) IS - 2509-9280 (Linking) VI - 10 IP - 1 DP - 2026 May 20 TI - Predicting resistance to neoadjuvant chemotherapy in osteosarcoma using machine learning with clinical data and T2-weighted MRI radiomics. LID - 10.1186/s41747-026-00732-z [doi] LID - 69 AB - OBJECTIVES: Identifying patients at risk of chemoresistant osteosarcoma enables risk-adapted management. This study aimed to predict chemoresistant osteosarcoma using baseline clinical and magnetic resonance (MRI)-derived radiomics features, with histological response as the reference standard and external validation included. MATERIALS AND METHODS: This retrospective single-center study included 115 patients with osteosarcoma from an institutional registry as the internal cohort, divided into training and test sets, and 49 patients from another institution as an external validation cohort. Tumor and peritumoral regions were manually segmented on baseline fat-suppressed T2-weighted MRI. Radiomics features were extracted using PyRadiomics, followed by two feature selection methods to identify potential predictors. Six machine learning models with varying feature combinations were trained to classify histologic chemoresistance in the internal training set. Model performance was assessed in the internal test set, and the best model was externally validated. RESULTS: The support vector machine model combining eight tumor radiomics features and four clinical-imaging parameters (presence of tumor necrosis > 50% on contrast-enhanced MRI, age, body mass index, and presence of metastasis at presentation) demonstrated the best performance. In the internal test set, it achieved a sensitivity of 83.3%, a specificity of 72.7%, an area under the receiver operating characteristic curve (AUROC) of 0.84, and a positive likelihood ratio of 3.06. External validation yielded a sensitivity of 88.5%, a specificity of 47.8%, and an AUROC of 0.77. CONCLUSION: A model combining tumor radiomics and clinical parameters at diagnosis showed strong performance in predicting chemoresistant osteosarcoma, with results confirmed by external validation. This approach may support personalized treatment strategies in high-grade osteosarcoma. RELEVANCE STATEMENT: The validated model may support early, individualized osteosarcoma management. KEY POINTS: Baseline T2-weighted MRI radiomics and clinical data can predict chemoresistant osteosarcoma. Tumor radiomics combined with clinical features achieved strong predictive accuracy. The support vector machine model reached an AUROC of 0.84 for the internal testing and of 0.77 for the external validation. The validated model may support early, individualized osteosarcoma management. CI - (c) 2026. The Author(s). FAU - Inkeaw, Papangkorn AU - Inkeaw P AD - Data Science Research Center, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand. AD - Global Health and Chronic Conditions Research Group, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. AD - Department of Computer Science, Faculty of Science, Chiang Mai University, Chiang Mai, Thailand. FAU - Pruksakorn, Dumnoensun AU - Pruksakorn D AD - Department of Orthopedics, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. AD - Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Angkurawaranon, Salita AU - Angkurawaranon S AD - Global Health and Chronic Conditions Research Group, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. AD - Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Morakote, Wipawee AU - Morakote W AD - Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Boonsri, Pattira AU - Boonsri P AD - Department of Radiology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand. FAU - Phettom, Rattanathon AU - Phettom R AD - Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. FAU - Kanthawang, Thanat AU - Kanthawang T AUID- ORCID: 0000-0002-1980-1903 AD - Center of Multidisciplinary Technology for Advanced Medicine (CMUTEAM), Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. thanatkanthawang@gmail.com. AD - Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. thanatkanthawang@gmail.com. LA - eng PT - Journal Article DEP - 20260520 PL - England TA - Eur Radiol Exp JT - European radiology experimental JID - 101721752 SB - IM MH - Humans MH - *Osteosarcoma/drug therapy/diagnostic imaging MH - *Radiomics MH - *Magnetic Resonance Imaging/methods MH - Retrospective Studies MH - *Drug Resistance, Neoplasm MH - Female MH - *Bone Neoplasms/drug therapy/diagnostic imaging MH - *Machine Learning MH - *Neoadjuvant Therapy MH - Male MH - Adolescent MH - Adult MH - Young Adult MH - Child MH - Predictive Learning Models PMC - PMC13191004 OTO - NOTNLM OT - Artificial intelligence OT - Drug resistance (neoplasm) OT - Magnetic resonance imaging OT - Osteosarcoma OT - Radiomics COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Institutional Review Board of Chiang Mai University (approval no. RAD-2566-0535) and the Institutional Review Board of Prince of Songkla University (approval no. 68-111-7-1). A data-sharing agreement was established between both institutions. The requirement for written informed consent was waived because this study involved retrospective data collection. Consent for publication: Written informed consent for publication of de-identified clinical information and imaging data was obtained from all patients in the internal dataset cohort. For the external dataset, all data and images were fully anonymized, and no directly or indirectly identifiable information is presented. Therefore, consent for publication is not applicable for the external dataset. Competing interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/20 12:39 MHDA- 2026/05/20 12:40 PMCR- 2026/05/20 CRDT- 2026/05/20 11:20 PHST- 2025/10/21 00:00 [received] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/03/24 00:00 [revised] PHST- 2026/05/20 12:40 [medline] PHST- 2026/05/20 12:39 [pubmed] PHST- 2026/05/20 11:20 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - 10.1186/s41747-026-00732-z [pii] AID - 732 [pii] AID - 10.1186/s41747-026-00732-z [doi] PST - epublish SO - Eur Radiol Exp. 2026 May 20;10(1):69. doi: 10.1186/s41747-026-00732-z. PMID- 42159483 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260730 IS - 1539-2570 (Electronic) IS - 0271-6798 (Linking) VI - 46 IP - 7 DP - 2026 Aug 1 TI - Is the Greulich and Pyle Bone Atlas Suitable When Measuring Bone Age for Pediatric ACL Reconstruction in the Modern US Population? Analysis Within the PLUTO Prospective Multicenter Cohort Study. PG - 442-449 LID - 10.1097/BPO.0000000000003340 [doi] AB - BACKGROUND: A reliable measure of bone age is of critical importance when planning anterior cruciate ligament reconstruction (ACLR) in a pediatric population. The Greulich and Pyle (G&P) method is still the most common method for bone age determination; however, it is based on radiographs from healthy Caucasian children of high socioeconomic status (SES) in Cleveland, Ohio, in the 1920s to 1940s and may not reflect the modern diverse United States population. The aim of our study was therefore to assess the degree of agreement between chronological age and bone age measured using G&P and further investigate whether there are any systematic differences across race, ethnicity, or SES. METHODS: This was a retrospective subanalysis of PLUTO (Pediatric ACL: Understanding Treatment Options), a prospective multicenter cohort study investigating outcomes in pediatric ACLR. All patients with bone age scores using the G&P method preoperatively were included. Data on race, ethnicity, biological sex, BMI, and SES [using a composite marker known as the area deprivation index (ADI)] were collected. Bland-Altman analysis was used to assess the agreement between chronological-measured and G&P-measured age. Systematic bias was defined as a significant mean difference between chronological-measured and G&P-measured age and was determined using Student t test for the cohort and within strata; and differences across strata were determined using a one-way ANOVA. P -values across strata were adjusted using the method of Benjamini and Hochberg to control the false discovery rate. RESULTS: A total of 472 patients were included in the final analysis. Chronological age at evaluation was lower than the determined bone age for the cohort with a systematic bias of 2.9 months (SD, 12.8) ( P <0.001). The Bland-Altman 95% limits of agreement between bone age and chronological age were approximately 2 years. There was significant variation in agreement in those aged 11 to 12 ( P <0.001), 13 ( P =0.008), and 15 years ( P =0.008). Female patients had a 3.9-month greater bias compared with males ( P =0.003). Underweight patients exhibited nearly 15.9 months lower bone age versus chronological age ( P =0.008). No systematic biases were detected across ethnicity ( P =0.21), race (0.13), or ADI index quartiles ( P =0.23). CONCLUSION: Our study supports the continued use of G&P for bone age assessment across different racial, ethnic, and sociodemographic groups, with no significant differences detected across these strata. The observed approximately 2-year limits of agreement between G&P bone age and chronological age reinforce the importance of skeletal age assessment in this cohort, particularly during the peripubertal period where large differences between chronological and skeletal age can exist. Systematic biases were found in certain age strata, between sexes, and in patients with low BMI. Clinicians should be aware of these variations and consider using multiple methods of assessing skeletal maturity when making growth-sensitive clinical decisions. LEVEL OF EVIDENCE: Level III-retrospective cohort. CI - Copyright (c) 2026 Wolters Kluwer Health, Inc. All rights reserved. FAU - Guevel, Borna AU - Guevel B AUID- ORCID: 0000-0002-7750-3197 AD - Boston Children's Hospital, Harvard Medical School, Boston, MA. FAU - Hutchinson, Lauren AU - Hutchinson L AD - Boston Children's Hospital, Harvard Medical School, Boston, MA. FAU - Miller, Patricia AU - Miller P AD - Boston Children's Hospital, Harvard Medical School, Boston, MA. FAU - Anderson, Christian N AU - Anderson CN AD - Tennessee Orthopaedic Alliance, Nashville, TN. FAU - Busch, Michael T AU - Busch MT AD - Children's Healthcare of Atlanta, Atlanta, GA. FAU - Chambers, Henry G AU - Chambers HG AD - Department of Orthopaedic Surgery, Rady Children's Hospital, University of California San Diego, San Diego. FAU - Christino, Melissa A AU - Christino MA AD - Boston Children's Hospital, Harvard Medical School, Boston, MA. FAU - Cordasco, Frank A AU - Cordasco FA AD - Hospital for Special Surgery, New York, NY. FAU - Edmonds, Eric W AU - Edmonds EW AD - Department of Orthopaedic Surgery, Rady Children's Hospital, University of California San Diego, San Diego. FAU - Fabricant, Peter D AU - Fabricant PD AD - Hospital for Special Surgery, New York, NY. FAU - Ganley, Theodore J AU - Ganley TJ AD - Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA. FAU - Green, Daniel W AU - Green DW AD - Hospital for Special Surgery, New York, NY. FAU - Heyworth, Benton E AU - Heyworth BE AD - Boston Children's Hospital, Harvard Medical School, Boston, MA. FAU - Lawrence, J Todd R AU - Lawrence JTR AD - Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA. FAU - Matava, Matthew J AU - Matava MJ AD - Department of Orthopaedic Surgery, Washington University in St Louis, St Louis, MO. FAU - Micheli, Lyle J AU - Micheli LJ AD - Boston Children's Hospital, Harvard Medical School, Boston, MA. FAU - Milewski, Matthew D AU - Milewski MD AD - Boston Children's Hospital, Harvard Medical School, Boston, MA. FAU - Nepple, Jeffrey J AU - Nepple JJ AD - Department of Orthopaedic Surgery, Washington University in St Louis, St Louis, MO. FAU - Parikh, Shital N AU - Parikh SN AD - Cincinnati Children's Hospital Medical Center, Cincinnati. FAU - Pennock, Andrew T AU - Pennock AT AD - Department of Orthopaedic Surgery, Rady Children's Hospital, University of California San Diego, San Diego. FAU - Perkins, Crystal A AU - Perkins CA AD - Children's Healthcare of Atlanta, Atlanta, GA. FAU - Saluan, Paul M AU - Saluan PM AD - Cleveland Clinic, Cleveland, OH. FAU - Shea, Kevin G AU - Shea KG AD - Stanford University, Stanford, CA. FAU - Wall, Eric J AU - Wall EJ AD - Cincinnati Children's Hospital Medical Center, Cincinnati. FAU - Willimon, Samuel C AU - Willimon SC AD - Children's Healthcare of Atlanta, Atlanta, GA. FAU - Kocher, Mininder S AU - Kocher MS AD - Boston Children's Hospital, Harvard Medical School, Boston, MA. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260520 PL - United States TA - J Pediatr Orthop JT - Journal of pediatric orthopedics JID - 8109053 SB - IM MH - Humans MH - *Age Determination by Skeleton/methods MH - Female MH - Male MH - Child MH - Prospective Studies MH - Adolescent MH - Retrospective Studies MH - *Anterior Cruciate Ligament Reconstruction/methods MH - United States MH - Cohort Studies MH - Anterior Cruciate Ligament/surgery OTO - NOTNLM OT - Greulich and Pyle OT - PLUTO OT - bone age OT - pediatric anterior cruciate ligament reconstruction OT - skeletal maturity COIS- The authors declare no conflicts of interest. EDAT- 2026/05/20 12:39 MHDA- 2026/07/09 00:40 CRDT- 2026/05/20 09:53 PHST- 2025/09/06 00:00 [received] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/07/09 00:40 [medline] PHST- 2026/05/20 12:39 [pubmed] PHST- 2026/05/20 09:53 [entrez] AID - 01241398-990000000-01167 [pii] AID - 10.1097/BPO.0000000000003340 [doi] PST - ppublish SO - J Pediatr Orthop. 2026 Aug 1;46(7):442-449. doi: 10.1097/BPO.0000000000003340. Epub 2026 May 20. PMID- 42159251 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261009 IS - 2044-835X (Electronic) IS - 0261-510X (Linking) VI - 44 IP - 4 DP - 2026 Nov TI - 24-h movement behaviours and inhibitory control in Chinese preschoolers: A compositional data analysis approach. PG - 801-817 LID - 10.1111/bjdp.70051 [doi] AB - This study investigated the relationships between 24-h movement behaviours and both 'cool' and 'hot' inhibitory control in Chinese preschoolers. Sixty-six children aged 3-6 years participated in this study. Twenty-four hours movement behaviours were assessed using validated questionnaires measuring moderate-to-vigorous physical activity (MVPA), light physical activity (LPA), sedentary behaviour (SB), and sleep duration (SLP). 'Cool' inhibitory control was measured using the Fish Flanker task, while 'hot' inhibitory control was assessed via the Emotion Flanker task. Compositional data analysis (CoDA) and isotemporal substitution modelling were employed for statistical analysis. The results showed that 24-h movement behaviours were significantly associated with both 'cool' and 'hot' inhibitory control. Increased SB was negatively associated with both 'cool' and 'hot' inhibitory control. Longer SLP was positively associated with both 'cool' and 'hot' inhibitory control. LPA showed a significant negative association with 'hot' inhibitory control. Isotemporal substitution analyses revealed that increasing MVPA and SLP while reducing SB and LPA was associated with enhanced control performance. This study demonstrates significant associations between 24-h movement behaviour and inhibitory control in preschoolers. The findings support the development of comprehensive movement guidelines that optimize the balance between physical activity, sedentary time, and sleep to promote cognitive development in early childhood. CI - (c) 2026 British Psychological Society. FAU - Zhu, Zhaohong AU - Zhu Z AD - School of Exercise and Health Sciences, Xi'an Physical Education University, Xi'an, China. FAU - Zhang, Shichen AU - Zhang S AUID- ORCID: 0009-0001-8415-8977 AD - School of Exercise and Health Sciences, Xi'an Physical Education University, Xi'an, China. FAU - Xu, Qinyu AU - Xu Q AD - School of Exercise and Health Sciences, Xi'an Physical Education University, Xi'an, China. FAU - Chen, Yuanyuan AU - Chen Y AD - School of Exercise and Health Sciences, Xi'an Physical Education University, Xi'an, China. FAU - Mao, Junxi AU - Mao J AD - School of Exercise and Health Sciences, Xi'an Physical Education University, Xi'an, China. LA - eng PT - Journal Article DEP - 20260520 PL - England TA - Br J Dev Psychol JT - The British journal of developmental psychology JID - 8308022 RN - Chinese people SB - IM MH - Humans MH - Female MH - Male MH - Child, Preschool MH - *Inhibition, Psychological MH - Child MH - *Child Behavior/physiology MH - *Exercise/physiology MH - Sleep Duration MH - *Sedentary Behavior MH - *Executive Function/physiology MH - China MH - East Asian People OTO - NOTNLM OT - 24-h movement behaviours OT - compositional data analysis OT - isotemporal substitution OT - preschool children OT - 'cool' inhibitory control OT - 'hot' inhibitory control EDAT- 2026/05/20 12:39 MHDA- 2026/10/08 17:35 CRDT- 2026/05/20 07:53 PHST- 2025/11/17 00:00 [received] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/10/08 17:35 [medline] PHST- 2026/05/20 12:39 [pubmed] PHST- 2026/05/20 07:53 [entrez] AID - 10.1111/bjdp.70051 [doi] PST - ppublish SO - Br J Dev Psychol. 2026 Nov;44(4):801-817. doi: 10.1111/bjdp.70051. Epub 2026 May 20. PMID- 42159103 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260720 IS - 1099-0496 (Electronic) IS - 1099-0496 (Linking) VI - 61 IP - 5 DP - 2026 May TI - Applicability of the Global Lung Initiative 2022 Spirometry Reference Equation Among Healthy Preschool-Aged Children in Jordan: A Comparative Study With GLI-2012 Equations. PG - e71675 LID - 10.1002/ppul.71675 [doi] AB - BACKGROUND: The Global Lung Initiative (GLI) Global 2022 spirometry equations do not require race selection at the point of interpretation, but their applicability in Middle Eastern preschool populations remains uncertain. Therefore, the present study aims to assess the applicability of the GLI global (2022) (GLI-2022) reference equations in a large sample of healthy Jordanian preschool-aged children and compare them with historically labeled GLI-2012 Caucasian (GLI-C) and Other/Mixed (GLI-O) equations. METHODS: A cross-sectional study was conducted with 911 healthy children (461 boys, 450 girls; age range 3-6 years) recruited from various regions in Jordan. Anthropometric and spirometric data (FEV(1), FVC, FEV(1)/FVC) were collected according to ATS/ERS standards. Race and ethnicity were not collected and were not used to assign equations. Instead, all participants were evaluated using each of the three equation sets. Z-Scores for each parameter were derived using the GLI-2022, GLI-C, and GLI-O equations. The validity of each equation set was evaluated by analyzing Z-score normality, performing regression analyses to detect residual bias from age and height, and assessing agreement in diagnostic classifications using Cohen's Kappa and Bland-Altman plots. RESULTS: The GLI-C equations demonstrated the closest statistical fit, with mean FEV(1) and FVC Z-scores closely centered on zero for both boys and girls. In contrast, the GLI-2022 and GLI-O equations produced significantly positive mean Z-scores for FEV(1) and FVC in both sexes (p < 0.001), indicating a systematic overestimation of lung function. The GLI-2022 equations showed significant residual anthropometric bias, with Z-scores remaining dependent on height and/or age (p < 0.01). Furthermore, the results indicated that diagnostic agreement between equations was inconsistent. CONCLUSION: The GLI-2022 race-neutral equations are not a suitable fit for preschool Jordanian children, and their use may lead to clinically significant misinterpretation of spirometric tests. These findings emphasize the critical need for population-specific reference equations for this population. CI - (c) 2026 Wiley Periodicals LLC. FAU - Al-Qerem, Walid AU - Al-Qerem W AUID- ORCID: 0000-0001-9831-7572 AD - Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman, Jordan. LA - eng PT - Comparative Study PT - Journal Article PL - United States TA - Pediatr Pulmonol JT - Pediatric pulmonology JID - 8510590 SB - IM MH - Humans MH - Jordan MH - Female MH - Male MH - *Spirometry/standards/methods MH - Child, Preschool MH - Cross-Sectional Studies MH - Reference Values MH - Child MH - *Lung/physiology MH - Forced Expiratory Volume MH - Vital Capacity OTO - NOTNLM OT - Global Lung Initiative (GLI) OT - Jordanian OT - lung function OT - preschool children OT - reference equations OT - spirometry EDAT- 2026/05/20 12:38 MHDA- 2026/05/20 12:39 CRDT- 2026/05/20 06:34 PHST- 2026/03/05 00:00 [revised] PHST- 2025/08/11 00:00 [received] PHST- 2026/05/15 00:00 [accepted] PHST- 2026/05/20 12:39 [medline] PHST- 2026/05/20 12:38 [pubmed] PHST- 2026/05/20 06:34 [entrez] AID - 10.1002/ppul.71675 [doi] PST - ppublish SO - Pediatr Pulmonol. 2026 May;61(5):e71675. doi: 10.1002/ppul.71675. PMID- 42158714 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260520 LR - 20260813 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 4 DP - 2026 Apr 30 TI - Incremental value of body composition indices in discriminating poorly controlled asthma in children: a cross-sectional study. PG - 102 LID - 10.21037/tp-2026-1-0102 [doi] LID - 102 AB - BACKGROUND: Asthma is the most common chronic respiratory disease in children, yet a considerable proportion of children have poorly controlled asthma despite advances in treatment. Traditional assessment models based on clinical indicators and lung function parameters show limited discriminatory ability. This study evaluated whether bioelectrical impedance analysis (BIA)-derived body composition indices-extracellular water-to-total body water ratio (ECW/TBW), phase angle (PhA), and visceral fat area (VFA)-improve the discrimination of poorly controlled asthma in children beyond traditional clinical assessments. METHODS: This cross-sectional study enrolled 103 children aged 6-14 years with asthma, categorized into poorly controlled (n=41) and well-controlled (n=62) groups. Two logistic regression models were constructed: a base model [age, sex, forced expiratory volume in 1 second (FEV(1)) % predicted, FEV(1)/forced vital capacity (FVC)] and an enhanced model adding body composition indices (ECW/TBW, PhA, VFA). Performance was evaluated using the area under the curve (AUC), net reclassification index (NRI), integrated discrimination improvement (IDI), and decision curve analysis. RESULTS: Children with poorly controlled asthma had elevated ECW/TBW (0.40 vs. 0.38, P<0.001) and decreased PhA (4.6 degrees vs. 5.2 degrees , P<0.001). In multivariable analysis, ECW/TBW was associated with increased risk of poorly controlled asthma [odds ratio (OR) =9.83, 95% confidence interval (CI): 3.53-27.37] and PhA was inversely associated (OR =0.17, 95% CI: 0.06-0.45). The enhanced model achieved an AUC of 0.893 vs. 0.618 for the base model (P<0.001), with sensitivity improving from 39.0% to 70.7% and specificity from 77.4% to 90.3%. The NRI was 0.446. CONCLUSIONS: BIA-derived body composition indices provided incremental discriminatory value for poorly controlled asthma beyond traditional assessment, potentially reflecting underlying systemic inflammation and metabolic disturbances. These findings warrant confirmation through multicenter studies with external validation. CI - (c) AME Publishing Company. FAU - Wang, Zhiyuan AU - Wang Z AUID- ORCID: 0000-0001-7990-9740 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. FAU - Zhao, Junlin AU - Zhao J AUID- ORCID: 0009-0002-9080-9622 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. FAU - Wang, Yanan AU - Wang Y AUID- ORCID: 0009-0008-3176-160X AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. FAU - Dai, Qianqian AU - Dai Q AUID- ORCID: 0009-0005-7647-0812 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. FAU - Wang, Xueli AU - Wang X AUID- ORCID: 0009-0003-3150-069X AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. FAU - Cui, Jianjiang AU - Cui J AUID- ORCID: 0009-0003-9767-7420 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. FAU - Ru, Liang AU - Ru L AUID- ORCID: 0009-0002-2200-3889 AD - Department of Pediatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China. LA - eng PT - Journal Article DEP - 20260428 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13181688 OTO - NOTNLM OT - Asthma OT - bioelectrical impedance analysis (BIA) OT - body composition OT - child OT - cross-sectional study COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-1-0102/coif). The authors have no conflicts of interest to declare. EDAT- 2026/05/20 06:31 MHDA- 2026/05/20 06:32 PMCR- 2026/04/30 CRDT- 2026/05/20 04:43 PHST- 2026/01/26 00:00 [received] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/05/20 06:32 [medline] PHST- 2026/05/20 06:31 [pubmed] PHST- 2026/05/20 04:43 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - tp-15-04-102 [pii] AID - 10.21037/tp-2026-1-0102 [doi] PST - ppublish SO - Transl Pediatr. 2026 Apr 30;15(4):102. doi: 10.21037/tp-2026-1-0102. Epub 2026 Apr 28. PMID- 42158673 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260520 LR - 20260813 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 4 DP - 2026 Apr 30 TI - Nursing management of deep vein thrombosis in children: a narrative review of challenges, evidence-based strategies, and systematic pathways. PG - 157 LID - 10.21037/tp-2026-1-0096 [doi] LID - 157 AB - BACKGROUND AND OBJECTIVE: Pediatric deep vein thrombosis (DVT) is an increasingly recognized vascular condition with potentially life-threatening consequences. Despite growing clinical awareness, nursing care remains challenging due to the lack of standardized, age-appropriate protocols-often defaulting to adult-oriented approaches. This review aims to synthesize current evidence on the multifactorial etiology, diagnostic challenges, and optimal nursing strategies for pediatric DVT, with a focus on improving early detection, individualized management, and long-term outcomes. METHODS: A narrative review was conducted to analyze peer-reviewed studies and clinical guidelines on pediatric DVT published in recent years, focusing on etiology, risk factors, diagnostic difficulties, and nursing interventions. KEY CONTENT AND FINDINGS: Pediatric DVT arises from a complex interplay of genetic thrombophilias, acquired triggers [e.g., central venous catheters (CVCs), infection], and immune-inflammatory mechanisms. Clinical presentation is highly variable and age-dependent, complicating early diagnosis. Effective nursing strategies include: (I) validated pediatric risk assessment; (II) individualized anticoagulation monitoring; (III) meticulous catheter care; (IV) early mobilization; and (V) nutritional support. Multidisciplinary collaboration, family-centered education, and psychological support are crucial for preventing post-thrombotic syndrome (PTS) and promoting recovery. CONCLUSIONS: A tailored, evidence-based nursing framework-grounded in pediatric physiology and centered on family engagement-is essential for optimizing DVT care in children. This review provides a practical foundation for developing standardized, high-quality nursing protocols to enhance safety, efficacy, and long-term outcomes in pediatric DVT management. CI - (c) AME Publishing Company. FAU - Huang, Yufen AU - Huang Y AD - Department of Emergency, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Hu, Yangchen AU - Hu Y AD - Department of Emergency, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Gao, Caina AU - Gao C AUID- ORCID: 0009-0005-5641-1209 AD - Department of Surgical Intensive Care Unit, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. FAU - Bao, Yiyao AU - Bao Y AUID- ORCID: 0009-0003-2185-2122 AD - Department of Surgical Intensive Care Unit, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China. LA - eng PT - Journal Article PT - Review DEP - 20260428 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13181668 OTO - NOTNLM OT - Children OT - deep vein thrombosis (DVT) OT - evidence-based strategies OT - nursing management OT - risk factors COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2026-1-0096/coif). The authors have no conflicts of interest to declare. EDAT- 2026/05/20 06:31 MHDA- 2026/05/20 06:32 PMCR- 2026/04/30 CRDT- 2026/05/20 04:42 PHST- 2026/01/25 00:00 [received] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/05/20 06:32 [medline] PHST- 2026/05/20 06:31 [pubmed] PHST- 2026/05/20 04:42 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - tp-15-04-157 [pii] AID - 10.21037/tp-2026-1-0096 [doi] PST - ppublish SO - Transl Pediatr. 2026 Apr 30;15(4):157. doi: 10.21037/tp-2026-1-0096. Epub 2026 Apr 28. PMID- 42158662 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260520 LR - 20260813 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 4 DP - 2026 Apr 30 TI - Comparison of DLIR-H and ASIR algorithms for image reconstruction in low-dose chest CT of pediatric mycoplasma pneumoniae pneumonia: a cross-sectional study. PG - 101 LID - 10.21037/tp-2025-1-923 [doi] LID - 101 AB - BACKGROUND: Pediatric Mycoplasma pneumoniae pneumonia (MPP) accounts for a significant number of cases of community-acquired pneumonia, and chest computed tomography (CT) is critical for its early diagnosis and prognosis assessment. However, clinical utilization is restricted due to concerns regarding radiation exposure. Adaptive statistical iterative reconstruction (ASIR) has been extensively employed in low-dose pediatric CT but suffers from noise texture distortion. In contrast, deep learning image reconstruction (DLIR) has shown promise for enhancing image quality in adult CT. Nevertheless, the comparative effectiveness of DLIR and ASIR in low-dose chest CT for pediatric MPP remains unvalidated, presenting a significant knowledge gap that this study endeavours to bridge. METHODS: In this retrospective cross-sectional study, consecutive pediatric patients who underwent low-dose chest CT (September 2023-March 2024) who were positive for MP-IgM and negative for other respiratory pathogen antibodies were included; patients with incomplete data, poor scan cooperation or a body mass index (BMI) >/=25 kg/m(2) were excluded. The raw CT data were reconstructed via ASIR at 0%, 50%, and 80% blending factors and DLIR at low, medium, and high-strength (DLIR-H) levels, using a standard kernel and a 1.25 mm slice thickness/interval. The standard deviation value of subcutaneous fat, the signal-to-noise ratio (SNR) of the lung parenchyma, and the contrast-to-noise ratio (CNR) of MPP were used to objectively evaluate the image quality. The subjective evaluation was scored by two senior radiologists using a 5-point scoring method, and the intraclass correlation coefficient (ICC) was determined for consistency analysis. RESULTS: Among the 235 screened patients, 142 (77 males and 65 females) were included (8.427+/-3.706 years), with a mean BMI of 16.19+/-1.83 kg/m(2). The mean effective dose was 1.17 (0.84-2.53 mSv), which met the Chinese low-dose guidelines. DLIR-H exhibited the lowest background noise (21.69, 38.3% lower than that of ASIR-80%) and the highest CNR of MPP (28.22, 14.7% higher than that of ASIR-80%). ASIR-80% had the highest SNR of the lung parenchyma (-14.46). DLIR-H achieved the highest subjective score (4.83+/-0.400, all P<0.001 vs. others) with substantial observer consistency (ICC >0.7). CONCLUSIONS: DLIR-H outperforms ASIR variants in low-dose pediatric chest CT, with minimal background noise, the highest lesion CNR and the best subjective quality at a clinically low effective dose, enhancing radiologists' diagnostic confidence and balancing radiation safety with imaging quality. Limitations include the retrospective design, DLIR-H's inferior lung parenchyma SNR, GE-only equipment compatibility, and unassessed MPP diagnostic accuracy. Prospective multicentre validation is required for broader clinical translation. CI - (c) AME Publishing Company. FAU - Zou, Ying AU - Zou Y AD - Department of Radiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. AD - Department of Radiology, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China. FAU - Bi, Hai AU - Bi H AD - Department of Radiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. AD - Department of Radiology, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China. FAU - Yang, Shouhong AU - Yang S AD - Department of Radiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. AD - Department of Radiology, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China. FAU - Li, Ruishi AU - Li R AD - Department of Pediatrics, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. AD - Department of Pediatrics, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China. FAU - Tan, Junyan AU - Tan J AD - Department of Radiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. AD - Department of Radiology, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China. FAU - Guo, Qingwei AU - Guo Q AD - Department of Radiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. AD - Department of Radiology, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China. FAU - Lu, Xiudi AU - Lu X AD - Department of Radiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. AD - Department of Radiology, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China. FAU - Liu, Jihua AU - Liu J AD - Department of Radiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China. AD - Department of Radiology, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China. LA - eng PT - Journal Article DEP - 20260428 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC13181691 OTO - NOTNLM OT - Mycoplasma pneumoniae OT - X-ray computed tomography OT - deep learning OT - qualitative evaluation OT - radiation dosage COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2025-1-923/coif). The authors have no conflicts of interest to declare. EDAT- 2026/05/20 06:31 MHDA- 2026/05/20 06:32 PMCR- 2026/04/30 CRDT- 2026/05/20 04:42 PHST- 2025/12/19 00:00 [received] PHST- 2026/03/18 00:00 [accepted] PHST- 2026/05/20 06:32 [medline] PHST- 2026/05/20 06:31 [pubmed] PHST- 2026/05/20 04:42 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - tp-15-04-101 [pii] AID - 10.21037/tp-2025-1-923 [doi] PST - ppublish SO - Transl Pediatr. 2026 Apr 30;15(4):101. doi: 10.21037/tp-2025-1-923. Epub 2026 Apr 28. PMID- 42158295 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260520 LR - 20260813 IS - 2055-7647 (Print) IS - 2055-7647 (Electronic) IS - 2055-7647 (Linking) VI - 12 IP - 2 DP - 2026 TI - Exercise as a preventive and therapeutic strategy for non-communicable diseases in people living with HIV: evidence, mechanisms and clinical implications. PG - e003128 LID - 10.1136/bmjsem-2025-003128 [doi] LID - e003128 AB - OBJECTIVE: To synthesise evidence on exercise for preventing and managing non-communicable diseases (NCDs) among HIV clients, emphasising sub-Saharan Africa. DESIGN: Narrative review. DATA SOURCES: Meta-analyses, randomised trials, cohort studies, mechanistic investigations and implementation reports involving adolescents and adults aged 15+ Priority was given to cardiometabolic, musculoskeletal, neurocognitive, immunological, behavioural, safety, feasibility and low- and middle-income country outcomes. RATIONALE: People living with HIV face elevated risk of cardiovascular disease, heart failure and type 2 diabetes due to persistent immune activation, chronic inflammation and treatment related metabolic effects. Exercise is a scalable, low-cost intervention with broad benefits. RESULTS: Aerobic and combined aerobic plus resistance training performed >/=3 times weekly for >/=5 weeks improves cardiorespiratory fitness and functional capacity with moderate effects, without adverse effects on CD4 or viral load. Resistance and concurrent training increase strength and lean mass and may attenuate bone mineral density loss. Exercise reduces depressive symptoms, improves quality of life and benefits attention and executive function. Mechanistic studies report reduced pro inflammation, improved endothelial function, enhanced mitochondrial capacity and greater antioxidant defence. Feasibility is high with appropriate screening and progression and with adaptations for neuropathy, frailty, pregnancy, low bone density and multimorbidity. Task shifting, digital or community delivery improve uptake despite limited evidence. CONCLUSIONS: Exercise should be integrated into HIV and NCD care using frequency, intensity, time and type principles. Programmes require risk stratification, age and sex sensitivity and behaviour change support. Further research should evaluate mechanistic endpoints, high-intensity interval training dosing, pragmatic delivery models and economic outcomes in low- and middle-income countries. CI - Copyright (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Mwebaze, Nicholas AU - Mwebaze N AUID- ORCID: 0009-0002-5893-2428 AD - Sports Science, Kyambogo University, Kampala, Central Region, Uganda. FAU - Makubuya, Timothy AU - Makubuya T AUID- ORCID: 0000-0002-9236-0876 AD - Kyambogo University, Kampala, Uganda. FAU - Nahwera, Loyce AU - Nahwera L AUID- ORCID: 0009-0001-3155-313X AD - Sports Science, Kyambogo University, Kampala, Central Region, Uganda. FAU - Nankwanga, Annet AU - Nankwanga A AUID- ORCID: 0009-0004-1564-640X AD - Physiotherapy, Soroti University, Soroti, Eastern Region, Uganda. FAU - Bwayo, Denis AU - Bwayo D AUID- ORCID: 0009-0003-5548-679X AD - Medicine, Busitema University Faculty of Health Sciences, Mbale, Uganda. AD - Medicine, Mbale Regional Referral Hospital, Mbale, Germany. FAU - Verhagen, Evert AU - Verhagen E AUID- ORCID: 0000-0001-9227-8234 AD - Medical & Anti-doping, UEFA, Nyon, Switzerland. AD - Amsterdam Collaboration on Health and Safety in Sports, Department of Public and Occupational Health, Amsterdam Movement Sciences, Amsterdam UMC Location VUmc, Amsterdam, Netherlands. LA - eng PT - Journal Article PT - Review DEP - 20260514 PL - England TA - BMJ Open Sport Exerc Med JT - BMJ open sport & exercise medicine JID - 101681007 PMC - PMC13182413 OTO - NOTNLM OT - Exercise OT - Exercise physiology OT - Non-communicable disease COIS- None declared. EDAT- 2026/05/20 06:32 MHDA- 2026/05/20 06:33 PMCR- 2026/05/14 CRDT- 2026/05/20 04:39 PHST- 2025/12/12 00:00 [received] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/05/20 06:33 [medline] PHST- 2026/05/20 06:32 [pubmed] PHST- 2026/05/20 04:39 [entrez] PHST- 2026/05/14 00:00 [pmc-release] AID - bmjsem-2025-003128 [pii] AID - 10.1136/bmjsem-2025-003128 [doi] PST - epublish SO - BMJ Open Sport Exerc Med. 2026 May 14;12(2):e003128. doi: 10.1136/bmjsem-2025-003128. eCollection 2026. PMID- 42157370 OWN - NLM STAT- Publisher LR - 20260520 IS - 1976-1902 (Print) IS - 1976-1902 (Linking) DP - 2026 May 20 TI - Effects of conservative exercise-based interventions on spinal curvature, respiratory function, and quality of life in patients with idiopathic scoliosis: a systematic review and meta-analysis. LID - 10.31616/asj.2025.0554 [doi] AB - STUDY DESIGN: Systematic review and meta-analysis. PURPOSE: This systematic review and meta-analysis aimed to evaluate the effectiveness of Schroth method (SM) on the spinal curvature, respiratory function, and quality of life (QoL) in patients with idiopathic scoliosis (IS). OVERVIEW OF LITERATURE: IS can cause substantial physical and psychological problems in both pediatric and juvenile populations, with significant repercussions in adulthood. The SM-based exercise intervention is a noninvasive therapeutic approach used for the conservative management of IS. METHODS: Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, we searched databases for studies evaluating Cobb angle, respiratory outcomes, and QoL in IS treated with exercise-based interventions. Rigorous methods of data extraction and risk of bias assessment were employed to assess methodological quality, followed by statistical analyses using a random-effects model to assess heterogeneity and perform subgroup analyses. The inverse of the variance was used as the statistical method, and the mean difference was used as the measure of effect. The robustness of the findings was validated using sensitivity analysis. RESULTS: Ten clinical trials were evaluated in this study. The meta-analysis revealed significant changes in the following outcomes using therapeutic exercise for IS: reduction in the Cobb angle, increases in the forced vital capacity (p =0.01), forced expiratory volume in one second (p =0.008), peak expiratory flow (p =0.000), and a decrease in pain intensity. Due to the limited number of bracing-related studies, no definitive conclusions regarding the effect of orthosis could be drawn. High heterogeneity was observed in the exercise subgroups, limiting the reliability and clinical interpretability of pooled estimates. CONCLUSIONS: Exercise-based interventions for IS, particularly the SM, are associated with small but statistically significant improvements in Cobb angle, respiratory function, pain, and functional capacity. However, the magnitude of change in spinal curvature reduction does not reach commonly accepted thresholds for clinical significance (PROSPERO registry number: CRD42024547664). FAU - Saornil, Jorge Velazquez AU - Saornil JV AD - UPSALUD Group, Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Pontificia de Salamanca, Salamanca, Spain. FAU - Reina, Maria Dolores Sosa AU - Reina MDS AD - Universidad Europea de Madrid, Faculty of Medicine, Health and Sports, Department of Physiotherapy, Madrid, Spain. FAU - de la Cruz, Sagrario Perez AU - de la Cruz SP AD - Department of Nursery, Physiotherapy and Medicine, University of Almeria, Almeria, Spain. FAU - Mila, Zacarias Sanchez AU - Mila ZS AD - NEUMUSK Group, Departamento de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Catolica de Avila, Avila, Spain. zacarias.sanchez@ucav.es. LA - eng PT - Journal Article DEP - 20260520 PL - Korea (South) TA - Asian Spine J JT - Asian spine journal JID - 101314177 OTO - NOTNLM OT - Exercise therapy OT - Lung function OT - Posture OT - Quality of life OT - Rehabilitation OT - Scoliosis EDAT- 2026/05/20 06:32 MHDA- 2026/05/20 06:32 CRDT- 2026/05/20 00:23 PHST- 2025/09/10 00:00 [received] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/05/20 06:32 [medline] PHST- 2026/05/20 06:32 [pubmed] PHST- 2026/05/20 00:23 [entrez] AID - asj.2025.0554 [pii] AID - 10.31616/asj.2025.0554 [doi] PST - aheadofprint SO - Asian Spine J. 2026 May 20. doi: 10.31616/asj.2025.0554. PMID- 42156949 OWN - NLM STAT- MEDLINE DCOM- 20260721 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 May 19 TI - Prevalence of irritable bowel syndrome and its association with lifestyle factors among medical students in Jordan: a cross-sectional survey. LID - 10.1038/s41598-026-52741-y [doi] LID - 22751 AB - Irritable Bowel Syndrome (IBS) is a common functional gastrointestinal disorder marked by chronic abdominal discomfort and altered bowel habits, including constipation, diarrhea, or a combination of both. It significantly impacts quality of life and is often linked to psychological stress and dietary factors. Given the scarcity of multi-university data from Jordan, this study aimed to determine the prevalence of IBS among medical students across three Jordanian universities and to identify associated lifestyle, psychological, and demographic risk factors using validated instruments. A cross-sectional survey was conducted among medical students from the University of Jordan, Mutah University, and Jordan University of Science and Technology across all academic levels. The Rome III criteria were employed to diagnose IBS. Sleep quality was evaluated using the SATED (Satisfaction, Alertness, Timing, Efficiency, and Duration) scale, and mental health status was assessed using the Hospital Anxiety and Depression Scale (HADS). A total of 572 students completed the questionnaire. IBS was identified in 33.74% of respondents. Among those with IBS, 31.1% had the constipation-predominant subtype, 18.1% had the diarrhea-predominant subtype, and 50.8% experienced mixed symptoms. Binary logistic regression revealed that a family history of IBS significantly increased the likelihood of having the disorder (OR: 1.95; 95% CI: 1.34-2.83). Other significant risk factors included smoking (OR: 1.43; 95% CI: 1.08-2.40) and anxiety borderline anxiety (OR: 1.76; 95% CI: 1.11-2.80; p = 0.01). Established anxiety (OR: 1.53; p = 0.06) did not reach statistical significance. Sixth-year students were found to be at highest risk (OR: 5.16; 95% CI: 1.84-14.41), possibly due to greater academic pressure. Regular physical activity was associated with lower IBS odds, though this did not reach statistical significance (OR: 0.6; p = 0.07). No significant association was found with gender, BMI, sleep quality, junk food consumption, or depression. IBS is prevalent among Jordanian medical students and is associated with both genetic predisposition and lifestyle factors. These findings underscore the importance of targeted mental health and lifestyle interventions - particularly for sixth-year students - and highlight the need for longitudinal research to establish causal pathways. To our knowledge, this is the first multi-university study in Jordan to simultaneously assess psychological, sleep, and lifestyle correlates of IBS in medical students using validated instruments, providing a foundation for evidence-based student health policy in the region. CI - (c) 2026. The Author(s). FAU - Alzoubi, Mohammad Nasri AU - Alzoubi MN AD - Department of General Surgery, Jordan University Hospital, The University of Jordan, Amman, Jordan. FAU - Aldhliki, Ameer Burhan AU - Aldhliki AB AD - School of Medicine, The University of Jordan, Amman, Jordan. FAU - Salameh, Hussam Eyad AU - Salameh HE AD - School of Medicine, The University of Jordan, Amman, Jordan. FAU - Al-Raymoony, Sara AU - Al-Raymoony S AD - School of Medicine, The University of Jordan, Amman, Jordan. FAU - Enayah, Majd AU - Enayah M AD - School of Medicine, The University of Jordan, Amman, Jordan. FAU - Ahmad, Hanan AU - Ahmad H AD - School of Medicine, The University of Mutah, Al-Karak, Jordan. FAU - Madi, Anas AU - Madi A AD - School of Medicine, The University of Jordan, Amman, Jordan. FAU - Al Kasem, Ahmad AU - Al Kasem A AD - School of Medicine, The University of Mutah, Al-Karak, Jordan. FAU - Abdallah, Noon AU - Abdallah N AD - School of Medicine, The University of Mutah, Al-Karak, Jordan. FAU - Safi, Yasmin AU - Safi Y AD - Department of Surgery, King Hussein Cancer Center, P.O. Box 1269, Amman, 11941, Jordan. FAU - Aljalabneh, Basim AU - Aljalabneh B AD - Department of Surgery, King Hussein Cancer Center, P.O. Box 1269, Amman, 11941, Jordan. DA.10229@KHCC.JO. LA - eng PT - Journal Article DEP - 20260519 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Jordan/epidemiology MH - *Students, Medical/psychology/statistics & numerical data MH - Female MH - Cross-Sectional Studies MH - Male MH - *Life Style MH - Prevalence MH - *Irritable Bowel Syndrome/epidemiology/psychology MH - Adult MH - Young Adult MH - Risk Factors MH - Surveys and Questionnaires MH - Quality of Life MH - Adolescent PMC - PMC13385915 OTO - NOTNLM OT - Irritable bowel syndrome OT - Jordan OT - Lifestyle factors OT - Medical students OT - Mental health OT - Prevalence COIS- Declarations. Consent to participate: Digital written consent was obtained from all participants after providing a detailed explanation of the study objectives and procedures. Participants were informed that their participation was voluntary and that they could withdraw at any time without any consequences. All completed questionnaires were kept anonymous and confidential, and all responses were used strictly for research purposes only. Access to the data was restricted to the research team, and all data were securely stored in compliance with institutional and ethical guidelines. Consent to publish: No personally identifiable information or images are included in this manuscript. Therefore, separate consent for publication was not required. Participants provided implied consent for the use of anonymized data for publication through their voluntary completion and submission of the survey. Ethics approval: This study was performed in accordance with the principles of the Declaration of Helsinki. The study was approved by the Ethics Committee of Research Council of the Faculty of Medicine at the University of Jordan (2682/2023/67). Competing interests: The authors declare no competing interests. EDAT- 2026/05/20 00:32 MHDA- 2026/07/21 06:34 PMCR- 2026/05/19 CRDT- 2026/05/19 23:41 PHST- 2025/06/29 00:00 [received] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/07/21 06:34 [medline] PHST- 2026/05/20 00:32 [pubmed] PHST- 2026/05/19 23:41 [entrez] PHST- 2026/05/19 00:00 [pmc-release] AID - 10.1038/s41598-026-52741-y [pii] AID - 52741 [pii] AID - 10.1038/s41598-026-52741-y [doi] PST - epublish SO - Sci Rep. 2026 May 19;16(1):22751. doi: 10.1038/s41598-026-52741-y. PMID- 42156871 OWN - NLM STAT- MEDLINE DCOM- 20260719 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 May 19 TI - Urinary miR-221-3p and miR-324-5p in combination with albuminuria as a promising model for non-invasive diagnosis of pediatric celiac disease. LID - 10.1038/s41598-026-53245-5 [doi] LID - 22635 AB - Celiac disease (CD) is a chronic autoimmune enteropathy triggered by gluten ingestion that can cause intestinal damage and extra-intestinal complications, including renal involvement in children. MicroRNAs (miRNAs) are small, stable, non-coding RNAs detectable in body fluids, and urinary miRNAs are particularly promising biomarkers due to their non-invasive collection and ability to reflect kidney function. While circulating miRNAs have been proposed as diagnostic markers of CD and indicators of adherence to a gluten-free diet (GFD), their role in monitoring renal alterations in pediatric patients remains unclear. Conventional measures, such as albuminuria, detect kidney damage but lack specificity for disease-related changes. Therefore, we aimed at exploring the possibility that urinary miRNAs coupled to albuminuria could be used to diagnose both CD and the presence of renal alterations. We analyzed urinary miRNA profiles in pediatric CD patients at diagnosis, on GFD, and in healthy controls. We found that urinary miR-221-3p and miR-324-5p and albuminuria are significantly dysregulated in children with CD compared to GFD and controls, identifying them as candidate biomarkers for diagnostic applications. Under GFD, their expression normalized supporting their potential role not only in monitoring renal recovery but also in objectively assessing dietary adherence. These findings highlight urinary miRNAs in combination with albuminuria as clinically relevant, non-invasive predictors for a non-invasive diagnosis of pediatric CD. More broadly, they suggest that urinary miRNA profiling could serve as a promising translational method to improve early detection, patient stratification, and longitudinal management across pediatric autoimmune disorders once fully validated in future larger cohorts. CI - (c) 2026. The Author(s). FAU - Paolini, Alessandro AU - Paolini A AD - Bambino Gesu Children's Hospital-IRCCS, Research Laboratories, Rome, Italy. FAU - Bruno, Stefania Paola AU - Bruno SP AD - Bambino Gesu Children's Hospital-IRCCS, Research Laboratories, Rome, Italy. FAU - Felli, Cristina AU - Felli C AD - Bambino Gesu Children's Hospital-IRCCS, Research Laboratories, Rome, Italy. FAU - Sandal, Semih AU - Sandal S AD - Department of Pediatric Gastroenterology, Ankara Training and Research Hospital, Altindag, 06230, Ankara, Turkey. FAU - Rostami-Nejad, Mohammad AU - Rostami-Nejad M AD - Celiac Disease and Gluten Related Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Muzi, Chantal AU - Muzi C AD - Bambino Gesu Children's Hospital-IRCCS, Research Laboratories, Rome, Italy. FAU - Cheri, Elena AU - Cheri E AD - Bambino Gesu Children's Hospital-IRCCS, Research Laboratories, Rome, Italy. FAU - Ferretti, Francesca AU - Ferretti F AD - Bambino Gesu Children's Hospital-IRCCS, Research Laboratories, Rome, Italy. AD - Gastroenterology and Nutritional Rehabilitation Unit, Bambino Gesu Children's Hospital-IRCCS, Rome, Italy. FAU - Masotti, Andrea AU - Masotti A AD - Bambino Gesu Children's Hospital-IRCCS, Research Laboratories, Rome, Italy. andrea.masotti@opbg.net. FAU - Baldassarre, Antonella AU - Baldassarre A AD - Bambino Gesu Children's Hospital-IRCCS, Research Laboratories, Rome, Italy. LA - eng GR - PNRR-POC-2022-12375779/European Union - Next Generation EU - NRRP M6C2 - Investment 2.1 Enhancement and strengthening of biomedical research in the NHS/ PT - Journal Article DEP - 20260519 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (MicroRNAs) RN - 0 (Biomarkers) RN - 0 (MIR221, human) SB - IM MH - Humans MH - *Celiac Disease/diagnosis/urine MH - *MicroRNAs/urine MH - Biomarkers/urine MH - *Albuminuria/urine/diagnosis MH - Child MH - Female MH - Male MH - Diet, Gluten-Free MH - Adolescent MH - Child, Preschool PMC - PMC13381913 OTO - NOTNLM OT - Albuminuria OT - Biomarkers OT - Celiac disease OT - Gluten-free diet OT - MicroRNAs OT - Urine COIS- Competing interests: The authors declare no competing interests. Ethical approval: The study was conducted in accordance with the Declaration of Helsinki, and approved by the Institutional Review Board (or Ethics Committee) of Bambino Gesu Children's Hospital-IRCCS (protocol code Progetto PNRR-POC-2022-12375779; 15/03/2023). Informed consent: Written informed consent was obtained from a parent and/or legal guardian of all subjects involved in the study for study participation and to publish this paper. EDAT- 2026/05/20 00:34 MHDA- 2026/07/20 00:37 PMCR- 2026/05/19 CRDT- 2026/05/19 23:38 PHST- 2026/01/08 00:00 [received] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/07/20 00:37 [medline] PHST- 2026/05/20 00:34 [pubmed] PHST- 2026/05/19 23:38 [entrez] PHST- 2026/05/19 00:00 [pmc-release] AID - 10.1038/s41598-026-53245-5 [pii] AID - 53245 [pii] AID - 10.1038/s41598-026-53245-5 [doi] PST - epublish SO - Sci Rep. 2026 May 19;16(1):22635. doi: 10.1038/s41598-026-53245-5. PMID- 42156819 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 May 19 TI - The impact of physical activity on rumination: a chain mediation model of executive function and metacognitive dysfunction and the examination of suppression effects. LID - 10.1038/s41598-026-51571-2 [doi] LID - 21002 AB - The present study aimed to examine the mediating roles of executive function and metacognitive dysfunction in the relationship between physical activity and rumination, as well as the suppressing effect within their parallel mediating pathways. From a cognitive architecture perspective, this study further explored the association pattern between physical activity and rumination among adolescents. A cross-sectional design was adopted in the present study, and data on physical activity, rumination, executive function and metacognitive dysfunction among adolescents were collected via a questionnaire survey and computerized neuropsychological tasks. A total of 603 Chinese adolescents were enrolled in the study (Mage = 16.058, SD = 0.828, male = 47.9%). Statistical analyses including reliability and validity analysis, confirmatory factor analysis, partial correlation analysis and structural equation model construction were conducted using SPSS 27.0 and AMOS 27.0, and the mediating effects were examined via the Bootstrap method. Physical activity was significantly associated with lower levels of rumination, with executive function and metacognitive dysfunction showing significant mediating associations. Specifically, higher levels of physical activity were associated with better executive function, which in turn was associated with lower rumination (beta = -0.141, 95% Confidence Interval [- 0.210, - 0.078]). In addition, physical activity was positively associated with metacognitive dysfunction, which was further associated with higher levels of rumination (beta = 0.091, 95% Confidence Interval [0.055, 0.133]). Similarly, higher levels of physical activity were associated with better executive function, which was further associated with lower levels of metacognitive dysfunction, and subsequently with lower rumination, and the reduction of metacognitive dysfunction can further decrease the occurrence of rumination (beta = -0.051, 95% Confidence Interval [- 0.078, - 0.029]). Furthermore, the parallel mediating pathways in the present study show inconsistent directions, presenting a statistically significant suppression effect, and the total indirect pathway effect is partially offset. The present study reveals that the relationship between physical activity and rumination may operate through multiple cognitive pathways with opposing directions, highlighting the structural roles of executive function and metacognitive dysfunction in this association. These findings provide a novel structural perspective for understanding the complexity of the psychological effects of physical activity and offer empirical references for the design of subsequent longitudinal or intervention studies. CI - (c) 2026. The Author(s). FAU - Cai, Dongsheng AU - Cai D AD - Institute of Sports Science, Nantong University, Nantong, China. FAU - Shi, Liteng AU - Shi L AD - Institute of Sports Science, Nantong University, Nantong, China. FAU - Yang, Yang AU - Yang Y AD - Institute of Sports Science, Nantong University, Nantong, China. FAU - Zhou, Yuan AU - Zhou Y AD - Institute of Sports Science, Nantong University, Nantong, China. FAU - Lu, Bochun AU - Lu B AD - Institute of Sports Science, Nantong University, Nantong, China. lubochun@ntu.edu.cn. FAU - Wang, Shimeng AU - Wang S AD - Institute of Sports Science, Nantong University, Nantong, China. wangsm@ntu.edu.cn. LA - eng GR - 23YJC890039/Humanities and Social Science Research Youth Fund, the Ministry of Education of China/ GR - 25KJD190001/Basic Science (Natural Science) Research Project for Higher Education Institutions in Jiangsu Province/ PT - Journal Article DEP - 20260519 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Executive Function/physiology MH - *Metacognition/physiology MH - *Exercise/psychology/physiology MH - Adolescent MH - *Rumination, Cognitive/physiology MH - Female MH - Male MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Neuropsychological Tests PMC - PMC13342091 OTO - NOTNLM OT - Adolescents OT - Chain mediation OT - Cognitive structure OT - Executive function OT - Metacognitive dysfunction OT - Physical activity OT - Rumination OT - Suppressing effect COIS- Declarations. Competing interests: The authors declare no competing interests. Consent for publication: Not applicable. EDAT- 2026/05/20 00:33 MHDA- 2026/07/08 12:56 PMCR- 2026/05/19 CRDT- 2026/05/19 23:36 PHST- 2026/02/12 00:00 [received] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/07/08 12:56 [medline] PHST- 2026/05/20 00:33 [pubmed] PHST- 2026/05/19 23:36 [entrez] PHST- 2026/05/19 00:00 [pmc-release] AID - 10.1038/s41598-026-51571-2 [pii] AID - 51571 [pii] AID - 10.1038/s41598-026-51571-2 [doi] PST - epublish SO - Sci Rep. 2026 May 19;16(1):21002. doi: 10.1038/s41598-026-51571-2. PMID- 42156442 OWN - NLM STAT- MEDLINE DCOM- 20260721 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 May 20 TI - Feasibility of mobile-based noncommunicable disease risk factor data collection using WhatsApp and interactive voice response in Colombia. LID - 10.1038/s41598-026-52589-2 [doi] LID - 22872 AB - The global increase in mobile phone usage, specifically in low- and middle-income countries (LMICs) provides opportunities for making non-communicable disease (NCD) data collection more efficient and economical. We investigated the feasibility of WhatsApp surveys and compared their population representativeness and NCD risk factor estimates with interactive voice response (IVR) surveys in Colombia. Participants were randomized to receive the NCD survey either via IVR or WhatsApp as the survey mode. Adults aged 18 years and over with a working mobile phone were sampled using random digit dialing (RDD). The survey included questions on demographics, tobacco use, alcohol consumption, and diet, with the primary difference in study arms being that visual examples (e.g., showcards) were used in the WhatsApp survey. We compared the demographic representativeness and NCD indicator estimates of the two surveys using log-binomial regression. The study was conducted between March 8 and March 12, 2023. Approximately 627 completed IVR surveys and 602 completed WhatsApp surveys were analyzed from 127,592 IVR and 2,632 WhatsApp calls (from 245,620 IVR enrollment calls). Overall, the WhatsApp arm had a higher proportion of young (18-44-year-olds: 81.9% vs. 74.2%), high-school educated (90.0% vs. 80.9%), and urban residents (80.4% vs. 73.4%) than IVR respondents. The overall prevalence/mean of most studied indicators was similar. For instance, with an adjusted risk ratio of 1.08 (95% CI: 0.83-1.40), the prevalence of tobacco smoking was 14.4% (95% CI: 11.7-17.3) and 16.4% (95% CI: 13.6-19.7) among IVR (ref.) and WhatsApp arms, respectively. The prevalence/mean differed for only two indicators: "number of vegetable servings consumed per day" and "<5 servings of fruits and/or vegetables consumed per day." Despite the inclusion of images in WhatsApp surveys, only minor differences in NCD indicators were found compared to IVR. Persistent gaps in rural and older populations must be addressed to ensure equitable monitoring in Colombia. CI - (c) 2026. The Author(s). FAU - Talwar, Amit AU - Talwar A AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe Street W5501, Baltimore, MD, 21205, USA. FAU - Al Kibria, Gulam Muhammed AU - Al Kibria GM AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe Street W5501, Baltimore, MD, 21205, USA. gkibria1@jhu.edu. FAU - Saavedra, Carolina AU - Saavedra C AD - Pontificia Universidad Javeriana, Bogota, Colombia. FAU - Agudelo-Londono, Sandra AU - Agudelo-Londono S AD - Pontificia Universidad Javeriana, Bogota, Colombia. FAU - Vecino-Ortiz, Andres AU - Vecino-Ortiz A AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe Street W5501, Baltimore, MD, 21205, USA. FAU - Kaufman, Michelle R AU - Kaufman MR AD - Department of Health, Behavior and Society, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD, 21205, USA. FAU - Nino, Julian Fernandez AU - Nino JF AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe Street W5501, Baltimore, MD, 21205, USA. FAU - Ruiz-Vallejo, Fernando AU - Ruiz-Vallejo F AD - Pontificia Universidad Javeriana, Bogota, Colombia. FAU - Gibson, Dustin G AU - Gibson DG AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, 615 N Wolfe Street W5501, Baltimore, MD, 21205, USA. LA - eng PT - Journal Article DEP - 20260520 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Colombia/epidemiology MH - Adult MH - Female MH - *Cell Phone MH - Adolescent MH - *Noncommunicable Diseases/epidemiology MH - Risk Factors MH - Middle Aged MH - Young Adult MH - Male MH - Feasibility Studies MH - *Data Collection/methods MH - *Mobile Applications MH - Surveys and Questionnaires MH - Aged PMC - PMC13389065 OTO - NOTNLM OT - Data collection OT - Interactive voice response OT - Mobile phone survey OT - Survey methods COIS- Declarations. Ethical approval and consent to participate: Ethical approval was received from the institutional review boards of the institutions involved in the study, namely the Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, U.S; and Pontificia Universidad Javeriana, Bogota, Colombia. All participants provided informed consent by pressing a number on their keypad. We only included adult individuals. Competing interests: The authors declare no competing interests. EDAT- 2026/05/20 00:34 MHDA- 2026/07/22 12:37 PMCR- 2026/05/20 CRDT- 2026/05/19 23:20 PHST- 2025/12/04 00:00 [received] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/07/22 12:37 [medline] PHST- 2026/05/20 00:34 [pubmed] PHST- 2026/05/19 23:20 [entrez] PHST- 2026/05/20 00:00 [pmc-release] AID - 10.1038/s41598-026-52589-2 [pii] AID - 52589 [pii] AID - 10.1038/s41598-026-52589-2 [doi] PST - epublish SO - Sci Rep. 2026 May 20;16(1):22872. doi: 10.1038/s41598-026-52589-2. PMID- 42155958 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260624 IS - 1879-1506 (Electronic) IS - 0003-9969 (Linking) VI - 188 DP - 2026 Aug TI - Assessing convolutional neural networks architectures for orthopantomography image analysis: Judicial dental age threshold classification. PG - 106626 LID - S0003-9969(26)00132-9 [pii] LID - 10.1016/j.archoralbio.2026.106626 [doi] AB - OBJECTIVE: Forensic dental age assessment is required when documentary evidence is absent or unreliable, and judicial decisions often depend on whether an individual falls below or above legally defined age thresholds. This pilot study evaluates ImageNet pretrained convolutional neural network architectures for binary age threshold classification. DESIGN: Orthopantomograms from individuals aged 0-25 years (1887 males and 1664 females) was selected using predefined inclusion criteria and labelled by chronological age. For each legal threshold (10, 12, 14, 16, 18 and 21 years), images were stratified into training and validation sets using an 80 20 split while preserving class distributions. Preprocessing included contrast enhancement with contrast limited adaptive histogram equalization, automated cropping, resizing to model specific input dimensions and ImageNet normalisation. Data augmentation was applied only to training images. Seven convolutional neural network architectures (ResNet 50, ResNet 152, VGG19, DenseNet 121, DenseNet 169, EfficientNetV2 M and Xception) were fine tuned in PyTorch using binary cross entropy loss with early stopping. Hyperparameters were optimised through Bayesian search targeting macro F1 score. Model interpretability was assessed using Grad CAM heatmaps reviewed by dental experts. RESULTS: EfficientNetV2 M showed the best performance for the 10-year threshold (accuracy: 0.935), DenseNet 169 for the 12-year threshold (accuracy: 0.945) and Xception for the remaining thresholds (accuracy: 14-year: 0.924; 16-year: 0.947; 18-year: 0.906; 21-year: 0.890). Errors clustered near age cut offs and increased at higher thresholds. Grad CAM highlighted posterior dento alveolar regions associated with root development. CONCLUSION: These results support convolutional neural network based orthopantomogram analysis as a judicial decision support approach and guided model selection for large scale evaluation. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Palmela Pereira, Cristiana AU - Palmela Pereira C AD - Faculdade de Medicina Dentaria da Universidade de Lisboa, Portugal; Centro de Estatistica e Aplicacoes da Universidade de Lisboa, Portugal. Electronic address: cpereira@edu.ulisboa.pt. FAU - Figueiras, Antonio AU - Figueiras A AD - Instituto Superior Tecnico, Universidade de Lisboa, Portugal. Electronic address: alpfigueiras@gmail.com. FAU - Nushi, Valon AU - Nushi V AD - Centro de Estatistica e Aplicacoes da Universidade de Lisboa, Portugal; Faculdade de Medicina da Universidade de Lisboa, Portugal. Electronic address: nushi.valon@gmail.com. FAU - Elbawab, Mohamed AU - Elbawab M AD - Instituto Superior Tecnico, Universidade de Lisboa, Portugal. Electronic address: mohamed.elbawab@tecnico.ulisboa.pt. FAU - Francisco, Alexandre AU - Francisco A AD - INESC-ID, Portugal. Electronic address: aplf@tecnico.ulisboa.pt. FAU - Oliveira, Arlindo AU - Oliveira A AD - INESC-ID, Portugal. Electronic address: arlindo.oliveira@tecnico.ulisboa.pt. FAU - Vaz, Catia AU - Vaz C AD - ISEL, Portugal. Electronic address: cvaz@cc.isel.ipl.pt. FAU - Santos, Rui AU - Santos R AD - Centro de Estatistica e Aplicacoes da Universidade de Lisboa, Portugal; Instituto Politecnico de Leiria, Portugal. Electronic address: rui.santos@ipleiria.pt. LA - eng PT - Journal Article DEP - 20260513 PL - England TA - Arch Oral Biol JT - Archives of oral biology JID - 0116711 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - *Radiography, Panoramic/methods MH - *Convolutional Neural Networks MH - Adolescent MH - Child MH - Male MH - Female MH - Infant MH - Child, Preschool MH - Pilot Projects MH - Young Adult MH - Adult MH - Infant, Newborn MH - *Image Processing, Computer-Assisted/methods MH - *Forensic Dentistry/methods OTO - NOTNLM OT - Age-threshold classification OT - Convolutional neural networks OT - Decision support systems OT - Forensic age assessment OT - Orthopantomography COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/20 00:35 MHDA- 2026/06/13 06:38 CRDT- 2026/05/19 19:40 PHST- 2026/01/03 00:00 [received] PHST- 2026/04/14 00:00 [revised] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/06/13 06:38 [medline] PHST- 2026/05/20 00:35 [pubmed] PHST- 2026/05/19 19:40 [entrez] AID - S0003-9969(26)00132-9 [pii] AID - 10.1016/j.archoralbio.2026.106626 [doi] PST - ppublish SO - Arch Oral Biol. 2026 Aug;188:106626. doi: 10.1016/j.archoralbio.2026.106626. Epub 2026 May 13. PMID- 42155862 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260923 IS - 1534-4436 (Electronic) IS - 1081-1206 (Print) IS - 1081-1206 (Linking) VI - 137 IP - 2 DP - 2026 Aug TI - Predictors of psychosocial burden in parents of children with food allergy. PG - 232-242.e8 LID - S1081-1206(26)00208-5 [pii] LID - 10.1016/j.anai.2026.05.010 [doi] AB - BACKGROUND: The psychosocial burden of food allergy (FA) impacts the entire family, particularly the affected child and their parents. OBJECTIVE: To evaluate psychosocial parental burden (PB) in families of children with FA, identify factors associated with PB, and assess its relationship with child-reported and parent-proxy food allergy quality of life (FAQOL). METHODS: A total of 114 children aged 2 to 17 years with IgE-mediated FA and their parents (mothers = 86.5%) completed validated age-specific FAQOL and PB questionnaires. Associations between demographic and clinical variables and scores were analyzed. RESULTS: Greater PB was associated with more frequent and/or severe reactions, reactions to trace allergen exposures, multiple FAs, wheat or unbaked milk or egg allergy, and/or a history of oral food challenge (regardless of outcome). Strict allergen avoidance practices were associated with worse PB; a parent working in healthcare was associated with better PB. The age, sex, ethnicity, and/or race of the child had no significant association. The PB scores correlated with FAQOL scores in children younger than 13 years, but not in children aged 13 years and older. Where both parental-proxy FAQOL and self-reported child FAQOL forms were available (age 8-12 years), scores were similar for questions pertaining to allergen avoidance and dietary restrictions, but parents reported less emotional impact of FA on their children than the children themselves reported. CONCLUSION: The number and severity of reactions, the type and number of FA, parents in the medical profession, and avoidance practices are associated with impacts on PB. The psychosocial well-being of parents was correlated with that of their children until age 13 years, but not after. Parents may underestimate the emotional impact of FA on their older children. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT02504853; Natural History and Genetics of Food Allergy and Related Conditions; https://clinicaltrials.gov/study/NCT02504853. CI - Published by Elsevier Inc. FAU - Kubala, Stephanie A AU - Kubala SA AD - Food Allergy Research Section, National Institute of Allergy and Infectious Diseases/National Institutes of Health, Bethesda, Maryland. FAU - Young, Fernanda D AU - Young FD AD - Food Allergy Research Section, National Institute of Allergy and Infectious Diseases/National Institutes of Health, Bethesda, Maryland. FAU - Callier, Viviane AU - Callier V AD - Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland. FAU - Rasooly, Marjohn M AU - Rasooly MM AD - Food Allergy Research Section, National Institute of Allergy and Infectious Diseases/National Institutes of Health, Bethesda, Maryland. FAU - Dempsey, Caeden AU - Dempsey C AD - Food Allergy Research Section, National Institute of Allergy and Infectious Diseases/National Institutes of Health, Bethesda, Maryland. FAU - Mateja, Allyson AU - Mateja A AD - Clinical Monitoring Research Program Directorate, Frederick National Laboratory for Cancer Research, Frederick, Maryland. FAU - Brittain, Erica AU - Brittain E AD - Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases/National Institutes of Health, North Bethesda, Maryland. FAU - Frischmeyer-Guerrerio, Pamela A AU - Frischmeyer-Guerrerio PA AD - Food Allergy Research Section, National Institute of Allergy and Infectious Diseases/National Institutes of Health, Bethesda, Maryland. Electronic address: pamela.guerrerio@nih.gov. LA - eng SI - ClinicalTrials.gov/NCT02504853 GR - 75N91019D00024/OD/NIH HHS/United States GR - Z99 AI999999/ImNIH/Intramural NIH HHS/United States GR - ZIA AI001202/ImNIH/Intramural NIH HHS/United States PT - Journal Article DEP - 20260520 PL - United States TA - Ann Allergy Asthma Immunol JT - Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology JID - 9503580 RN - 0 (Allergens) SB - IM MH - Humans MH - Child MH - Female MH - Male MH - *Food Hypersensitivity/psychology/epidemiology/immunology MH - Adolescent MH - *Parents/psychology MH - Child, Preschool MH - *Quality of Life MH - Surveys and Questionnaires MH - *Cost of Illness MH - Allergens/immunology PMC - PMC13276776 MID - NIHMS2185886 COIS- Disclosures The authors have no conflicts of interest to report. EDAT- 2026/05/20 00:35 MHDA- 2026/07/30 00:38 PMCR- 2026/06/19 CRDT- 2026/05/19 19:38 PHST- 2025/12/12 00:00 [received] PHST- 2026/04/17 00:00 [revised] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/07/30 00:38 [medline] PHST- 2026/05/20 00:35 [pubmed] PHST- 2026/05/19 19:38 [entrez] PHST- 2026/06/19 00:00 [pmc-release] AID - S1081-1206(26)00208-5 [pii] AID - 10.1016/j.anai.2026.05.010 [doi] PST - ppublish SO - Ann Allergy Asthma Immunol. 2026 Aug;137(2):232-242.e8. doi: 10.1016/j.anai.2026.05.010. Epub 2026 May 20. PMID- 42155401 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1873-7358 (Electronic) IS - 1471-0153 (Linking) VI - 61 DP - 2026 Apr TI - Sleep, mood, and binge eating: Evidence from a student sample. PG - 102092 LID - S1471-0153(26)00025-5 [pii] LID - 10.1016/j.eatbeh.2026.102092 [doi] AB - OBJECTIVE: Binge eating is a transdiagnostic symptom that occurs along a continuum and is common in the general population. Sleep difficulties are widespread in clinical eating disorders populations and carry important implications for treatment and outcome; yet it remains unclear if similar difficulties occur in individuals with undiagnosed binge eating. The present study investigated the relationship between binge eating and sleep in an undiagnosed student sample, using both objective and subjective measures of sleep quality and duration. A secondary aim was to examine whether difficulties in emotional regulation contribute to this relationship. METHOD: Sixty-nine participants without a diagnosis of an eating disorder were classified into low or moderate-to-high binge eating groups and completed a 7-day protocol in which sleep was continuously monitored via the MotionWatch 8. Validated self-report questionnaires were administered to assess low mood, sleep quality, eating disorder symptomatology, worry, daytime sleepiness, and chronotype. RESULTS: Individuals with moderate-to-high binge eating reported poorer perceived sleep alongside higher levels of low mood and worry, despite no detectable differences in actigraphy derived sleep. Low mood - but not worry - emerged as a significant mediator of the relationship between sleep and binge eating. DISCUSSION: Together, these findings highlight the importance of considering affective processes and sleep perception, rather than objective sleep alone, when examining sleep-binge eating links in undiagnosed populations. This may have important implications for sleep research in at-risk and undiagnosed eating disorders samples, as well as for the development of public health interventions. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Martinelli, Cristina AU - Martinelli C AD - City St Georges, University of London, United Kingdom; Kingston University, United Kingdom. Electronic address: cristina.martinelli@citystgeorges.ac.uk. FAU - Spano, Goffredina AU - Spano G AD - City St Georges, University of London, United Kingdom. LA - eng PT - Journal Article DEP - 20260514 PL - United States TA - Eat Behav JT - Eating behaviors JID - 101090048 SB - IM MH - Humans MH - Female MH - *Affect/physiology MH - *Bulimia/psychology/physiopathology MH - Male MH - Students/psychology MH - Young Adult MH - Adult MH - Sleep Quality MH - *Sleep/physiology MH - Chronotype MH - Surveys and Questionnaires MH - Actigraphy MH - Adolescent MH - *Sleep Wake Disorders/psychology MH - Binge-Eating Disorder/psychology MH - Anxiety/psychology MH - Emotional Regulation/physiology OTO - NOTNLM OT - Actigraphy OT - Affective symptoms OT - Binge eating OT - Eating disorders OT - Sleep COIS- Declaration of competing interest The authors report no conflict of interest to disclose. EDAT- 2026/05/20 00:35 MHDA- 2026/05/29 15:42 CRDT- 2026/05/19 18:19 PHST- 2026/01/27 00:00 [received] PHST- 2026/05/10 00:00 [revised] PHST- 2026/05/11 00:00 [accepted] PHST- 2026/05/29 15:42 [medline] PHST- 2026/05/20 00:35 [pubmed] PHST- 2026/05/19 18:19 [entrez] AID - S1471-0153(26)00025-5 [pii] AID - 10.1016/j.eatbeh.2026.102092 [doi] PST - ppublish SO - Eat Behav. 2026 Apr;61:102092. doi: 10.1016/j.eatbeh.2026.102092. Epub 2026 May 14. PMID- 42154887 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2177-6709 (Electronic) IS - 2176-9451 (Print) IS - 2176-9451 (Linking) VI - 31 IP - 2 DP - 2026 TI - Pediatric validation of an AI-assisted smartphone application (WebCeph) for cephalometric analysis: reliability, reproducibility and time-efficiency assessment. PG - e2625274 LID - S2176-94512026000200603 [pii] LID - 10.1590/2177-6709.31.2.e2625274.oar [doi] LID - e2625274 AB - INTRODUCTION: Although AI-assisted cephalometric applications are widely used, most validation studies involve adult radiographs. Pediatric craniofacial landmarks show greater variability due to growth, which may influence automated landmark accuracy. Therefore, pediatric-specific validation of AI-based smartphone cephalometry is essential. OBJECTIVE: This study evaluated the reliability, reproducibility, and time-efficiency of an AI-assisted smartphone application (WebCeph) compared with manual cephalometric tracing in children. METHODS: A retrospective cross-sectional study was conducted on 51 lateral cephalograms of children aged 7-12 years. Manual tracings were performed by a calibrated examiner, and digital tracings were obtained using the WebCeph Android application. Linear and angular measurements were recorded for both methods. Intra-examiner reliability was assessed using intraclass correlation coefficients (ICC). Agreement between methods was evaluated using paired t-tests and Cohen's d. Tracing time was documented, and normality was confirmed using the Shapiro-Wilk test. RESULTS: Both methods demonstrated high reliability. Most parameters showed no significant differences, although a few (SNA, ANB, L1-MP) showed statistically significant but clinically negligible discrepancies. ICC values indicated excellent agreement. WebCeph significantly reduced analysis time (9.4 +/- 1.82 minutes), compared with manual tracing (19.4 +/- 2.65 minutes). CONCLUSION: The WebCeph AI-assisted smartphone application provides reliable and clinically comparable cephalometric measurements to manual tracing in pediatric patients, with substantial time savings. It may serve as an efficient adjunct to routine pediatric orthodontic diagnostics, with consideration for growth-related landmark variability. FAU - Shinde, Rohan AU - Shinde R AUID- ORCID: 0009-0009-2914-7552 AD - Pacific Dental College & Hospital, Department of Pediatric Dentistry (Udaipur, Rajasthan State, India). FAU - Rao, Dinesh AU - Rao D AUID- ORCID: 0000-0002-1794-3334 AD - Pacific Dental College & Hospital, Department of Pediatric Dentistry (Udaipur, Rajasthan State, India). FAU - Panwar, Sunil AU - Panwar S AUID- ORCID: 0000-0003-3642-5863 AD - Pacific Dental College & Hospital, Department of Pediatric Dentistry (Udaipur, Rajasthan State, India). FAU - Phalke, Manan AU - Phalke M AUID- ORCID: 0000-0001-9735-3387 AD - Pacific Dental College & Hospital, Department of Pediatric Dentistry (Udaipur, Rajasthan State, India). LA - eng PT - Journal Article PT - Validation Study DEP - 20260518 PL - Brazil TA - Dental Press J Orthod JT - Dental press journal of orthodontics JID - 101532240 SB - IM MH - Humans MH - Child MH - *Cephalometry/methods MH - *Smartphone MH - Reproducibility of Results MH - Retrospective Studies MH - Cross-Sectional Studies MH - Female MH - *Mobile Applications MH - Male MH - Time Factors MH - Anatomic Landmarks MH - Observer Variation PMC - PMC13185514 COIS- The authors report no commercial, proprietary or financial interest in the products or companies described in this article. EDAT- 2026/05/19 18:32 MHDA- 2026/05/19 18:33 PMCR- 2026/05/18 CRDT- 2026/05/19 14:05 PHST- 2025/10/10 00:00 [received] PHST- 2025/12/09 00:00 [accepted] PHST- 2026/05/19 18:33 [medline] PHST- 2026/05/19 18:32 [pubmed] PHST- 2026/05/19 14:05 [entrez] PHST- 2026/05/18 00:00 [pmc-release] AID - S2176-94512026000200603 [pii] AID - 10.1590/2177-6709.31.2.e2625274.oar [doi] PST - epublish SO - Dental Press J Orthod. 2026 May 18;31(2):e2625274. doi: 10.1590/2177-6709.31.2.e2625274.oar. eCollection 2026. PMID- 42154860 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260730 IS - 1943-7722 (Electronic) IS - 0002-9173 (Linking) VI - 165 IP - 5 DP - 2026 May 5 TI - Defining baseline high-sensitivity cardiac troponin levels in healthy collegiate athletes. LID - aqag042 [pii] LID - 10.1093/ajcp/aqag042 [doi] AB - OBJECTIVES: Cardiac troponin (cTn) is a critical biomarker for diagnosing myocardial injury; however, intense physical activity can transiently elevate cTn concentrations, creating diagnostic challenges in athletic populations. High-sensitivity cardiac troponin assays (hs-cTn) further complicate discrimination between physiologic and pathologic elevations. METHODS: This study characterized baseline high-sensitivity cardiac troponin I (hs-cTnI) distributions in collegiate athletes and evaluated associations with sex, time since exercise, sport type, and creatine kinase-MB (CK-MB). We analyzed baseline hs-cTnI values from 173 elite collegiate athletes (98 women, 75 men) representing 21 sports. RESULTS: The median hs-cTnI concentration (<4 ng/L) was identical between sexes, but divergence emerged in the upper distribution tail, with hs-cTnI values exceeding population-derived 99th percentile upper reference limits occurring at lower percentiles in men than women (73rd vs 85th percentile), resulting in a higher prevalence of abnormal classifications in men (28% vs 17%, P < .01). Ninety-fifth percentile values were similar between sexes, whereas divergence was confined to the extreme upper tail (99th percentile). Abnormal hs-cTnI values were more frequent when samples were collected <48 hours after exercise compared with >/=48 hours (29% vs 16%, P = .04). No association was observed between hs-cTnI and CK-MB (P = .37). Significant differences emerged between sports (P = .02), with the highest proportions of abnormal hs-cTnI observed among cross-country (80%), sailing (44%), and rowing (35%) athletes. CONCLUSIONS: These findings support athlete-focused interpretation of hs-cTnI incorporating sex-specific thresholds, standardized postexercise sampling, and sport context. Such tailored approaches may reduce false-positive results and unnecessary evaluations while preserving diagnostic accuracy for true myocardial pathology. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of American Society for Clinical Pathology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Jamal, Yaseen A AU - Jamal YA AUID- ORCID: 0009-0009-0565-1682 AD - Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States. FAU - Montiel, Avery AU - Montiel A AD - Department of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, United States. FAU - Jones, Skyler AU - Jones S AD - Department of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, United States. FAU - Nair, Priyanka AU - Nair P AD - Department of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, United States. FAU - Parikh, Victoria AU - Parikh V AD - Department of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, United States. FAU - Haddad, Francois AU - Haddad F AUID- ORCID: 0000-0002-9648-7671 AD - Department of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, United States. FAU - Wheeler, Matthew T AU - Wheeler MT AD - Department of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, United States. FAU - Hwang, Calvin AU - Hwang C AD - Department of Orthopedic Surgery, Stanford University School of Medicine, Stanford, CA, United States. FAU - Tso, Jason V AU - Tso JV AD - Department of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, United States. FAU - Bowen, Raffick A R AU - Bowen RAR AUID- ORCID: 0000-0002-7652-8560 AD - Department of Pathology, Stanford University School of Medicine, Stanford, CA, United States. LA - eng GR - Department of Pathology, Stanford University School of Medicine/ PT - Journal Article PL - England TA - Am J Clin Pathol JT - American journal of clinical pathology JID - 0370470 RN - 0 (Troponin I) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Male MH - Female MH - *Troponin I/blood MH - *Athletes MH - Biomarkers/blood MH - Young Adult MH - Reference Values MH - Adult MH - Adolescent MH - Sports MH - Exercise/physiology OTO - NOTNLM OT - high-sensitivity cardiac troponin I OT - hs-cTnI OT - troponin EDAT- 2026/05/19 18:32 MHDA- 2026/05/19 18:33 CRDT- 2026/05/19 14:04 PHST- 2026/01/28 00:00 [received] PHST- 2026/04/04 00:00 [accepted] PHST- 2026/05/19 18:33 [medline] PHST- 2026/05/19 18:32 [pubmed] PHST- 2026/05/19 14:04 [entrez] AID - 8687580 [pii] AID - 10.1093/ajcp/aqag042 [doi] PST - ppublish SO - Am J Clin Pathol. 2026 May 5;165(5):aqag042. doi: 10.1093/ajcp/aqag042. PMID- 42154372 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20261012 IS - 1399-3038 (Electronic) IS - 0905-6157 (Linking) VI - 37 IP - 5 DP - 2026 May TI - Nutritional intervention with a partially hydrolyzed formula during the first 6 months of life may reduce the risk of food allergy and atopic dermatitis up to the age of 5 years. PG - e70354 LID - 10.1111/pai.70354 [doi] AB - BACKGROUND: Evidence on the effectiveness of partially hydrolyzed formulas (pHF) as a nutritional intervention to prevent Allergic Manifestations (AM) is limited. Provided that not all pHF are the same in terms of allergenicity and immunogenicity, their role in reducing the risk of the Atopic March progression should be individually and longitudinally examined. OBJECTIVE: To investigate whether the risk-reduction effect of a specific pHF compared to a standard formula (SF) on Atopic Dermatitis (AD) within the first 6 months of life observed in the Allergy Reduction Trial (A.R.T.) persists at the age of 5 years and, if it applies to other AM. METHODS: Parents/legal guardians of participants within the multicenter double-blinded randomized controlled clinical Allergy Reduction Trial (A.R.T.) who constituted the Intention-to-Treat population set (N = 551) were invited at the age of 5 years for an observational follow-up, to answer an enriched validated questionnaire regarding doctor diagnosis of AM between 1 and 5 years of age, including AD, Food Allergy (FA), Asthma, and Allergic Rhinitis (AR). The prevalence and cumulative incidence of outcomes were calculated and Relative Risks, 95% Confidence Interval (RR, 95% CI) were estimated by Poisson Generalized Estimating Equations adjusted for study center, sex, family history of AD, family history of AR, family history of Asthma, and mode of delivery. RESULTS: Four hundred and fifty-five subjects (83%) completed the 5-year follow-up (pHF: 131/160, SF: 145/171 and EBF: 179/220). The RR from birth to 5 years was significantly lower in the pHF group, for the development of any AM [32.7% vs. 51.7%, RR 0.73 (0.57-0.94), p = .02], AD [22.1% vs. 38.5%, RR 0.58 (0.41-0.83), p = .003] and, FA [10.5% vs. 20.4%, RR 0.53 (0.29-0.95), p = .03] compared to the SF group. Infant feeding with the pHF resulted in 87% risk-reduction of FA [1.5% vs. 12.4%, RR 0.13 (0.03-0.58), p = .007] between the ages of 1-5 years. CONCLUSION: In non-exclusively breastfed infants at high-risk for allergy, mixed-feeding with a specific whey-based pHF during the first 6 months of life may reduce the risk of atopic dermatitis and food allergy from birth up to the age of 5 years. However, further A.R.T. follow-ups and other longitudinal studies with larger sample size are needed to provide additional evidence for the long-term effectiveness of pHF in allergy prevention. CI - (c) 2026 The Author(s). Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. FAU - Sekkidou, Mikaela AU - Sekkidou M AUID- ORCID: 0009-0001-8796-8334 AD - Asthma and Allergy Center, Limassol, Cyprus. AD - Department of Basic and Clinical Sciences, University of Nicosia Medical School, Nicosia, Cyprus. FAU - Karglani, Eva AU - Karglani E AD - Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece. AD - European Centre for Obesity, Harokopio University, Athens, Greece. FAU - Pancheva, Rouzha AU - Pancheva R AD - Department of Hygiene and Epidemiology, Faculty of Public Health, "Prof. Dr. Paraskev Stoyanov" Medical University - Varna, Varna, Bulgaria. FAU - Kantaras, Paris AU - Kantaras P AD - Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece. FAU - Popova, Simoneta AU - Popova S AD - Department of Hygiene and Epidemiology, Faculty of Public Health, "Prof. Dr. Paraskev Stoyanov" Medical University - Varna, Varna, Bulgaria. FAU - Zhelyazkova, Desislava AU - Zhelyazkova D AD - Department of Hygiene and Epidemiology, Faculty of Public Health, "Prof. Dr. Paraskev Stoyanov" Medical University - Varna, Varna, Bulgaria. FAU - Yiallouros, Panayiotis K AU - Yiallouros PK AUID- ORCID: 0000-0002-8339-9285 AD - Medical School, University of Cyprus, Nicosia, Cyprus. FAU - Philippou, Elena AU - Philippou E AD - Department of Life Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus. FAU - Daniil, Vasiliki AU - Daniil V AD - Neonatal Department, National and Kapodistrian University of Athens, Aretaieio Hospital, Athens, Greece. FAU - Boutsikou, Theodora AU - Boutsikou T AD - Neonatal Department, National and Kapodistrian University of Athens, Aretaieio Hospital, Athens, Greece. FAU - Iliodromiti, Zoi AU - Iliodromiti Z AD - Neonatal Department, National and Kapodistrian University of Athens, Aretaieio Hospital, Athens, Greece. FAU - Iacovidou, Nicoletta AU - Iacovidou N AD - Neonatal Department, National and Kapodistrian University of Athens, Aretaieio Hospital, Athens, Greece. FAU - Papaevangelou, Vassiliki AU - Papaevangelou V AD - Third Department of Pediatrics, National and Kapodistrian University of Athens, ATTIKON General University Hospital, Athens, Greece. FAU - Manios, Yannis AU - Manios Y AD - Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece. AD - Department of Life Sciences, School of Life and Health Sciences, University of Nicosia, Nicosia, Cyprus. AD - Institute of Agri-Food and Life Sciences, Hellenic Mediterranean University Research Centre, Crete, Greece. FAU - van Lee, Linde AU - van Lee L AD - FrieslandCampina, Amersfoort, the Netherlands. FAU - Nicolaou, Nicolaos AU - Nicolaou N AD - Asthma and Allergy Center, Limassol, Cyprus. AD - Department of Basic and Clinical Sciences, University of Nicosia Medical School, Nicosia, Cyprus. LA - eng GR - FrieslandCampina Nederland B.V./ PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - England TA - Pediatr Allergy Immunol JT - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JID - 9106718 SB - IM EIN - Pediatr Allergy Immunol. 2026 Oct;37(10):e70494. doi: 10.1111/pai.70494. PMID: 42860873 MH - Humans MH - *Dermatitis, Atopic/epidemiology/prevention & control MH - Infant MH - *Food Hypersensitivity/epidemiology/prevention & control MH - Female MH - Male MH - Child, Preschool MH - *Infant Formula MH - Double-Blind Method MH - Follow-Up Studies MH - Infant, Newborn MH - Prevalence MH - Incidence MH - Hydrolysis OTO - NOTNLM OT - allergy prevention OT - atopic dermatitis OT - breastfeeding OT - food allergy OT - partially hydrolyzed formula EDAT- 2026/05/19 12:36 MHDA- 2026/05/19 12:37 CRDT- 2026/05/19 11:17 PHST- 2026/03/27 00:00 [revised] PHST- 2025/11/18 00:00 [received] PHST- 2026/04/13 00:00 [accepted] PHST- 2026/05/19 12:37 [medline] PHST- 2026/05/19 12:36 [pubmed] PHST- 2026/05/19 11:17 [entrez] AID - 10.1111/pai.70354 [doi] PST - ppublish SO - Pediatr Allergy Immunol. 2026 May;37(5):e70354. doi: 10.1111/pai.70354. PMID- 42153348 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260908 IS - 1365-3156 (Electronic) IS - 1360-2276 (Print) IS - 1360-2276 (Linking) VI - 31 IP - 9 DP - 2026 Sep TI - Epidemiological, Spatial and Predictive Analysis of Tuberculosis-Related Mortality in the Department of Risaralda (Colombia), 2020-2024. PG - 1284-1290 LID - 10.1111/tmi.70168 [doi] AB - OBJECTIVE: To analyse the epidemiological characteristics, spatial distribution and predictors of TB-related mortality in Risaralda from 2020 to 2024. METHODS: A retrospective observational study was conducted using secondary data from the National Public Health Surveillance System (SIVIGILA). Descriptive statistics, spatial analysis (choropleth maps) and binary logistic regression were used to identify sociodemographic and clinical factors associated with TB case fatality. Model performance was evaluated using ROC curves, sensitivity, specificity and 5-fold cross-validation. RESULTS: A total of 2081 confirmed TB cases were analysed, with a case fatality rate of 13.2%. Mortality was higher among individuals >/= 65 years (OR: 3.87), hospitalized patients (OR: 7.33), HIV-positive individuals (OR: 3.49), those with undernutrition (OR: 1.89), males (OR: 1.45) and Indigenous persons (OR: 1.67). The logistic model showed good discrimination (AUC: 0.82), with sensitivity of 79.2% and specificity of 73.8%. Cross-validation confirmed model stability (AUC: 0.81). Spatial analysis revealed high mortality in rural municipalities with low case burden, suggesting health inequities. CONCLUSION: TB mortality in Risaralda is influenced by age, comorbidities and social determinants, with pronounced territorial disparities. These findings support the integration of spatial and predictive tools in TB surveillance to strengthen targeted interventions and reduce mortality in high-risk populations. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Patino-Palma, Brayan Esneider AU - Patino-Palma BE AUID- ORCID: 0000-0002-6932-0980 AD - ZIPATEFI Research Group, Fundacion Universitaria del Area Andina, Pereira, Colombia. FAU - Chacon-Bambague, Sandra Yineth AU - Chacon-Bambague SY AUID- ORCID: 0009-0000-2196-8190 AD - ZIPATEFI Research Group, Fundacion Universitaria del Area Andina, Pereira, Colombia. FAU - Bermudez-Moreno, Farhlyn Paola AU - Bermudez-Moreno FP AD - GIER Research Group, Fundacion Universitaria del Area Andina, Pereira, Colombia. LA - eng PT - Journal Article PT - Observational Study DEP - 20260519 PL - England TA - Trop Med Int Health JT - Tropical medicine & international health : TM & IH JID - 9610576 SB - IM MH - Humans MH - Male MH - Retrospective Studies MH - Female MH - *Tuberculosis/mortality/epidemiology MH - Aged MH - Colombia/epidemiology MH - Middle Aged MH - Adult MH - Spatial Analysis MH - Adolescent MH - Young Adult MH - Risk Factors MH - Logistic Models MH - Child, Preschool MH - Infant PMC - PMC13533626 OTO - NOTNLM OT - Colombia OT - epidemiology OT - logistic models OT - mortality OT - risk factors OT - spatial analysis OT - tuberculosis COIS- The authors declare no conflicts of interest. EDAT- 2026/05/19 06:30 MHDA- 2026/09/01 23:34 PMCR- 2026/09/02 CRDT- 2026/05/19 05:33 PHST- 2026/02/04 00:00 [revised] PHST- 2025/07/13 00:00 [received] PHST- 2026/04/06 00:00 [accepted] PHST- 2026/09/01 23:34 [medline] PHST- 2026/05/19 06:30 [pubmed] PHST- 2026/05/19 05:33 [entrez] PHST- 2026/09/02 00:00 [pmc-release] AID - TMI70168 [pii] AID - 10.1111/tmi.70168 [doi] PST - ppublish SO - Trop Med Int Health. 2026 Sep;31(9):1284-1290. doi: 10.1111/tmi.70168. Epub 2026 May 19. PMID- 42152555 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261020 IS - 1467-1107 (Electronic) IS - 1047-9511 (Linking) VI - 36 IP - 5 DP - 2026 May TI - The 3-minute Step Test predicts cardiometabolic health in children. PG - 950-954 LID - 10.1017/S1047951126112888 [doi] AB - BACKGROUND: This study evaluated whether the 3-minute Step Test, a submaximal measure of cardiorespiratory fitness, can predict cardiometabolic and arterial health in youth with atherosclerosis-promoting cardiometabolic risk factors. METHODS: Children and adolescents attended a paediatric preventive cardiology clinic for management of cardiometabolic risk factors. Cardiorespiratory fitness was assessed using a 3-minute Step Test, where an individual steps up/down on a 6-inch step at 24 steps/min for 3 minutes. The percentage of age-predicted maximum heart rate that was attained at the end of the Step Test was recorded as a measure of physiological work (cardiorespiratory fitness). Lifestyle-influenced cardiometabolic risk factors included: body anthropometrics [body mass index z-score, waist-to-height ratio z-score], systolic blood pressure, and serum markers [triglycerides, high-density lipoprotein cholesterol, haemoglobin A1C, alanine aminotransferase, vitamin D]. Arterial function was assessed by measuring pulse wave velocity and was normalised to sex and height-specific z-score. RESULTS: The sample included 482 patients [age 14.31 +/- 2.38 years, 261 (53%) male]. A higher percent predicted peak heart rate strongly correlated with worse lifestyle-influenced cardiometabolic risk factors and with higher pulse wave velocity, suggesting increased arterial stiffness. CONCLUSION: Percent predicted peak heart rate from the 3-minute Step Test was associated with cardiometabolic and arterial health. The 3-minute Step Test is an inexpensive, quick, and low-resource-intensive method to estimate cardiorespiratory fitness, cardiometabolic and arterial health in an outpatient clinical setting. FAU - Watson, Jessica S AU - Watson JS AUID- ORCID: 0000-0002-9235-9672 AD - Children's Mercy Hospital and Clinics, Kansas City, MO, USA. ROR: https://ror.org/04zfmcq84 AD - School of Medicine, University of Missouri-Kansas City, USA. ROR: https://ror.org/01w0d5g70 FAU - Riforgiate, Elizabeth AU - Riforgiate E AD - School of Medicine, University of Kansas, Kansas City, KS, USA. FAU - Helmick, MacKenzie AU - Helmick M AD - Children's Mercy Hospital and Clinics, Kansas City, MO, USA. ROR: https://ror.org/04zfmcq84 FAU - White, David A AU - White DA AUID- ORCID: 0000-0002-4320-5351 AD - Children's Mercy Hospital and Clinics, Kansas City, MO, USA. ROR: https://ror.org/04zfmcq84 AD - School of Medicine, University of Missouri-Kansas City, USA. ROR: https://ror.org/01w0d5g70 FAU - Sherman, Ashley K AU - Sherman AK AD - Children's Mercy Hospital and Clinics, Kansas City, MO, USA. ROR: https://ror.org/04zfmcq84 FAU - Raghuveer, Geetha AU - Raghuveer G AD - Children's Mercy Hospital and Clinics, Kansas City, MO, USA. ROR: https://ror.org/04zfmcq84 AD - School of Medicine, University of Missouri-Kansas City, USA. ROR: https://ror.org/01w0d5g70 LA - eng PT - Journal Article DEP - 20260519 PL - England TA - Cardiol Young JT - Cardiology in the young JID - 9200019 SB - IM MH - Humans MH - Male MH - Female MH - *Cardiorespiratory Fitness/physiology MH - Adolescent MH - *Exercise Test/methods MH - Child MH - Cardiometabolic Risk Factors MH - *Heart Rate/physiology MH - Pulse Wave Analysis MH - Blood Pressure/physiology MH - *Cardiovascular Diseases/physiopathology MH - Predictive Value of Tests MH - Risk Factors OTO - NOTNLM OT - Step test OT - arterial health OT - cardiometabolic health OT - children OT - lipid profile EDAT- 2026/05/19 06:30 MHDA- 2026/10/20 17:34 CRDT- 2026/05/19 02:03 PHST- 2026/10/20 17:34 [medline] PHST- 2026/05/19 06:30 [pubmed] PHST- 2026/05/19 02:03 [entrez] AID - S1047951126112888 [pii] AID - 10.1017/S1047951126112888 [doi] PST - ppublish SO - Cardiol Young. 2026 May;36(5):950-954. doi: 10.1017/S1047951126112888. Epub 2026 May 19. PMID- 42152436 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260824 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 5 DP - 2026 May 15 TI - Couples problem-solving therapy for perinatal women living with HIV and male partners in Malawi: a study protocol for a pilot trial of Mphatso. PG - e115210 LID - 10.1136/bmjopen-2025-115210 [doi] LID - e115210 AB - INTRODUCTION: Perinatal depression is a common, yet understudied, mental health disorder among women and contributes to poor engagement in prevention of mother-to-child transmission (PMTCT) of HIV in sub-Saharan Africa. Male partners are positioned to provide critical forms of social and economic support during pregnancy and postpartum, and also may contribute to women's stress, depression and anxiety through intimate partner violence and withholding of social support. Despite the critical role of men in pregnancy outcomes and HIV prevention, few interventions have engaged men around women's depressive symptoms, nutrition and health, and engagement in PMTCT. We will conduct a pilot trial of Mphatso, a couple-based intervention based on problem-solving therapy with couple relationship skills to reduce depressive symptoms in perinatal women, improve food insecurity and prevent HIV transmission to the infant. METHODS AND ANALYSIS: We will employ a two-arm pilot randomised controlled trial in the Zomba district of Malawi to assess the feasibility and acceptability of Mphatso (meaning 'gift' or the child) and explore health impacts on depressive symptoms, PMTCT engagement and food insecurity. We will enrol 60 pregnant women in the second or third trimester who are living with HIV and meet criteria for probable depression based on the Edinburgh Postnatal Depression Scale and their male partners. Couples will be randomised to receive either five sessions of Mphatso (problem-management skills plus health education and relationship skills) or enhanced usual care. Feasibility and acceptability outcomes will include session attendance rates, satisfaction levels and retention at 3 months and 6 months postpartum. Exploratory analyses using regression models including time and treatment arm will be conducted to explore effects on the mothers' and fathers' depressive symptoms, adherence to PMTCT (antiretroviral therapy, nevirapine use, HIV testing and exclusive breastfeeding) and food insecurity. ETHICS AND DISSEMINATION: The pilot trial has been approved by the University of California, San Francisco (Human Research Protection Program (HRPP); Protocol Number 23-40685), and the study has also been approved by the National Health Sciences Research Committee in Malawi (NHSRC; Protocol Number 24/05/4431). Results will be disseminated to study participants, health officials, policymakers, community leaders and care providers, as well as through presentations at conferences and publications in peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT06659315. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Conroy, Amy A AU - Conroy AA AUID- ORCID: 0000-0002-0609-5077 AD - Department of Medicine, University of California San Francisco, San Francisco, California, USA amy.conroy@ucsf.edu. FAU - Butterfield, Rita M AU - Butterfield RM AD - Department of Medicine, University of California San Francisco, San Francisco, California, USA. FAU - Mkandawire, James AU - Mkandawire J AD - Invest in Knowledge (IKI), Zomba, Malawi. FAU - Mulauzi, Nancy AU - Mulauzi N AD - Invest in Knowledge (IKI), Zomba, Malawi. FAU - Bengtson, Angela M AU - Bengtson AM AD - Rollins School of Public Health, Emory University, Atlanta, Georgia, USA. FAU - Neilands, Torsten B AU - Neilands TB AD - Department of Medicine, University of California San Francisco, San Francisco, California, USA. FAU - Weiser, Sheri D AU - Weiser SD AUID- ORCID: 0000-0002-7807-4072 AD - Department of Medicine, University of California San Francisco, San Francisco, California, USA. FAU - Johnson, Mallory O AU - Johnson MO AD - Department of Medicine, University of California San Francisco, San Francisco, California, USA. LA - eng SI - ClinicalTrials.gov/NCT06659315 GR - R34 MH134725/MH/NIMH NIH HHS/United States PT - Clinical Trial Protocol PT - Journal Article DEP - 20260515 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Female MH - *HIV Infections/transmission/psychology/prevention & control MH - Pilot Projects MH - Malawi MH - Pregnancy MH - Male MH - *Infectious Disease Transmission, Vertical/prevention & control MH - *Problem Solving MH - *Depression/therapy MH - *Couples Therapy/methods MH - *Sexual Partners/psychology MH - Randomized Controlled Trials as Topic MH - Adult MH - Food Supply MH - *Pregnancy Complications, Infectious/psychology PMC - PMC13182488 OTO - NOTNLM OT - Africa South of the Sahara OT - Depression, Postpartum OT - HIV & AIDS COIS- Competing interests: None declared. EDAT- 2026/05/19 06:30 MHDA- 2026/05/19 06:31 PMCR- 2026/05/15 CRDT- 2026/05/19 01:02 PHST- 2026/05/19 06:31 [medline] PHST- 2026/05/19 06:30 [pubmed] PHST- 2026/05/19 01:02 [entrez] PHST- 2026/05/15 00:00 [pmc-release] AID - bmjopen-2025-115210 [pii] AID - 10.1136/bmjopen-2025-115210 [doi] PST - epublish SO - BMJ Open. 2026 May 15;16(5):e115210. doi: 10.1136/bmjopen-2025-115210. PMID- 42152169 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260712 LR - 20260813 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 12 IP - 1 DP - 2026 May 18 TI - Whole and refined grains consumption and social interaction in children: a cross-sectional study. LID - 10.1186/s40795-026-01350-z [doi] LID - 133 AB - BACKGROUND: Social interaction is fundamental to a child's mental health and development. While diet is a known modulator of brain function, the specific roles of refined versus whole grain intake on social behaviors in children are not well understood. This study aimed to investigate association between refined and whole grain consumption and social interaction scores among Iranian children. METHODS: This cross-sectional study recruited 313 children aged 7-13 years from Kashan, Iran. Dietary intake was assessed using a validated 168-item food frequency questionnaire (FFQ). Social interaction was evaluated using the 40-item Social Communication Questionnaire (SCQ), where higher scores indicate greater difficulties with communication. Multivariable linear regression models were used to assess association between grain intake and SCQ scores, adjusting for a comprehensive set of demographics, socioeconomic, anthropometric, and dietary confounders. RESULTS: In the fully adjusted model, total refined grains intake was significantly associated with higher SCQ scores (beta‌: 0.007, 95% CI: 0.005, 0.009; P < 0.001). Conversely, total whole grain was associated with lower SCQ scores (beta‌: -0.006, 95% CI: -0.009, -0.002; P < 0.001). CONCLUSION: In this study, higher intake of refined grains was associated with poorer social interaction, while greater consumption of whole grains was associated with more favorable social behaviors in Iranian children. Future longitudinal and interventional studies are required to clarify the causal relationship between grain quality and social interaction in children of different countries. CI - (c) 2026. The Author(s). FAU - Aliakbari, Mohammadreza AU - Aliakbari M AD - Student Scientific Research Center (SSRC), Tehran University of Medical Sciences, Tehran, Iran. FAU - Haghighat Lari, Mohammad Mehdi AU - Haghighat Lari MM AD - Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran. AD - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. FAU - Nouri, Pania AU - Nouri P AD - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. FAU - Mollaei, Maryam AU - Mollaei M AD - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. FAU - Kermanizadeh Jamkarani, Zahra AU - Kermanizadeh Jamkarani Z AD - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. FAU - Nematolahi, Faezeh AU - Nematolahi F AD - Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran. AD - Department of Nutrition, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Milajerdi, Alireza AU - Milajerdi A AD - Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran. amkhv@yahoo.com. LA - eng PT - Journal Article DEP - 20260518 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC13359884 OTO - NOTNLM OT - Children OT - Dietary patterns OT - Refined grains OT - SCQ OT - Social interaction OT - Whole grains COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Kashan University of Medical Sciences (IR.KAUMS.MEDNT.REC.1403.117). The study was conducted in accordance with the principles of the Declaration of Helsinki. Written informed consent was obtained from the parents of all participants prior to enrollment in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/19 06:30 MHDA- 2026/05/19 06:31 PMCR- 2026/05/18 CRDT- 2026/05/19 00:19 PHST- 2026/02/20 00:00 [received] PHST- 2026/05/05 00:00 [accepted] PHST- 2026/05/19 06:31 [medline] PHST- 2026/05/19 06:30 [pubmed] PHST- 2026/05/19 00:19 [entrez] PHST- 2026/05/18 00:00 [pmc-release] AID - 10.1186/s40795-026-01350-z [pii] AID - 1350 [pii] AID - 10.1186/s40795-026-01350-z [doi] PST - epublish SO - BMC Nutr. 2026 May 18;12(1):133. doi: 10.1186/s40795-026-01350-z. PMID- 42152104 OWN - NLM STAT- MEDLINE DCOM- 20260913 LR - 20260916 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 25 IP - 1 DP - 2026 May 18 TI - Feeding problems in infancy and diet quality in later childhood: a prospective cohort study. LID - 10.1186/s12937-026-01311-z [doi] LID - 99 AB - BACKGROUND: Feeding problems affect many children, yet their connection with diet quality in later childhood is unknown, despite the important role of diet quality on health outcomes, such as obesity. OBJECTIVE: To examine feeding problem behaviors and diet quality in later childhood. DESIGN: The frequency of problematic feeding behaviors (i.e., items related to food refusal, feeding difficulties, and distress) were parent-reported at 18 and 24 months in a birth cohort (2008-2010) from New York state (n = 4,989). In this previously validated feeding behaviors scale, parents responded to how often their child engaged in behaviors such as crying/screaming during meals and food refusal, to create an average feeding problems score. Typical daily servings of food items that a child consumed were parent-reported at 30 months, 36 months, 7 years, and 9 years and diet quality using the Youth Healthy Eating Index (YHEI) was calculated, with a higher score indicating better diet quality. Mixed effects analyses calculated mean differences in YHEI per unit increase in feeding problem scores, adjusting for sociodemographic and health-related factors, such as parental education, gestational age, and any breastfeeding duration. RESULTS: Feeding problem scores at 18 and 24 months were prospectively associated with lower YHEI scores at 30/36 months (18 months: B = -1.10, 95% CI: -1.93, -0.27; 24 months: B = -1.56, 95% CI: -2.33, -0.79). Similar associations were observed at 7/9 years (18 months: B = -1.30, 95% CI: -2.61, 0.00; 24 months: B = -1.65, 95% CI: -2.96, -0.34). CONCLUSIONS: Higher feeding problems in infancy (18 and 24 months) were associated with lower quality diets in childhood, even after children started school. These findings highlight the importance of feeding behaviors to long-term diet quality even with observations as early as 18 months. TRIAL REGISTRATION: NCT03106493 in clinicaltrials.gov (Dates: 07/2008-11/2019, Study Registration Date: 2017-04-10). CI - (c) 2026. Akhgar Ghassabian. Parts of this work were authored by US Federal Government authors and are not under copyright protection in the US; foreign copyright protection may apply. FAU - Jankowski, Emma AU - Jankowski E AD - Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6710B Rockledge Dr, MSC 7004, Bethesda, MD, 20817, USA. AD - Division of Epidemiology, College of Public Health, The Ohio State University, Columbus, OH, 43210, USA. FAU - Putnick, Diane L AU - Putnick DL AD - Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6710B Rockledge Dr, MSC 7004, Bethesda, MD, 20817, USA. FAU - Ghassabian, Akghar AU - Ghassabian A AD - Grossman School of Medicine, New York University, New York, NY, 10016, USA. FAU - Clayton, Priscilla K AU - Clayton PK AD - Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6710B Rockledge Dr, MSC 7004, Bethesda, MD, 20817, USA. FAU - Lin, Tzu-Chun AU - Lin TC AD - Glotech, Inc., 1801 Research Boulevard #605, Rockville, MD, 20850, USA. FAU - Yeung, Edwina H AU - Yeung EH AUID- ORCID: 0000-0002-3851-2613 AD - Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH, 6710B Rockledge Dr, MSC 7004, Bethesda, MD, 20817, USA. yeungedw@mail.nih.gov. LA - eng SI - ClinicalTrials.gov/NCT03106493 GR - contracts #HHSN275201200005C, #HHSN267200700019C, #HHSN275201400013C, #HHSN275201300026I/27500004, #HHSN275201300023I/27500017/the Intramural Research Program of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, NIH/ GR - HHSN267200700019C/HD/NICHD NIH HHS/United States GR - HHSN275201300026I/HD/NICHD NIH HHS/United States GR - HHSN275201400013C/HD/NICHD NIH HHS/United States GR - HHSN275201200005C/HD/NICHD NIH HHS/United States PT - Journal Article PT - Observational Study DEP - 20260518 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - *Diet MH - *Diet, Healthy/statistics & numerical data MH - *Feeding Behavior/psychology MH - New York/epidemiology MH - Prospective Studies PMC - PMC13573370 OTO - NOTNLM OT - Children OT - Diet quality OT - Feeding problems OT - Healthy eating COIS- Declarations. Ethics approval and consent to participate: Human subjects approval was obtained from all participating institutions (NYSDOH IRB #07-097; UAlbany #08-179), and informed consent was obtained prior to data collection. Informed consent to participate for minors (participants under the age of 16) was obtained from parents or legal guardians. All procedures performed in this study were in accordance with the ethical standards of the 1964 Helsinki Declaration and its later amendments. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/19 06:30 MHDA- 2026/09/14 05:35 PMCR- 2026/05/18 CRDT- 2026/05/19 00:16 PHST- 2025/09/11 00:00 [received] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/09/14 05:35 [medline] PHST- 2026/05/19 06:30 [pubmed] PHST- 2026/05/19 00:16 [entrez] PHST- 2026/05/18 00:00 [pmc-release] AID - 10.1186/s12937-026-01311-z [pii] AID - 1311 [pii] AID - 10.1186/s12937-026-01311-z [doi] PST - epublish SO - Nutr J. 2026 May 18;25(1):99. doi: 10.1186/s12937-026-01311-z. PMID- 42151309 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 May 18 TI - Longitudinal associations between adherence to 24-h movement guidelines and physical fitness and body composition in pediatric overweight and obesity. LID - 10.1038/s41598-026-53270-4 [doi] LID - 22375 AB - This study investigated the longitudinal associations between adherence to the 24-h Movement Guidelines (24-HMG), specifically, meeting the recommendations for moderate-to-vigorous physical activity (MVPA) (>/= 60 min/day), recreational screen time ( 0.05). The mean operative time was comparable between groups (TULAA: 54.94 +/- 24.97 min vs. TPLA: 58.65 +/- 25.58 min, p = 0.356). However, the TULAA group demonstrated a significantly shorter average hospital stay (4.83 +/- 1.53 days vs. 5.35 +/- 1.19 days, p = 0.022). Conversely, the time to first postoperative flatus was significantly longer in the TULAA group (25.81 +/- 11.00 h vs. 21.13 +/- 10.01 h, p = 0.006). The overall complication rate showed no significant difference (TULAA: 4.6% vs. TPLA: 6.5%, p > 0.05), with all cases managed conservatively. CONCLUSION: For pediatric acute appendicitis, TULAA is a safe and feasible minimally invasive technique, resulting in a significantly reduced hospital stay compared to TPLA despite a slightly delayed return of bowel function. Both techniques demonstrate comparable operative times and overall complication rates. TULAA represents a valuable surgical option within the pediatric minimally invasive arsenal. CI - (c) 2026 Li. FAU - Li, Yifan AU - Li Y AD - Department of Pediatric Surgery, Maternity & Child Healthcare Hospital of Longgang District, Shenzhen City (Longgang Maternity and Child Institute of Shantou University Medical College), Shenzhen, China. LA - eng PT - Journal Article DEP - 20260501 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13176303 OTO - NOTNLM OT - acute appendicitis OT - children OT - laparoscopic appendectomy OT - minimally invasive surgery OT - transumbilical laparoscopic-assisted appendectomy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/18 12:43 MHDA- 2026/05/18 12:44 PMCR- 2026/05/01 CRDT- 2026/05/18 06:49 PHST- 2025/10/14 00:00 [received] PHST- 2026/02/19 00:00 [revised] PHST- 2026/02/20 00:00 [accepted] PHST- 2026/05/18 12:44 [medline] PHST- 2026/05/18 12:43 [pubmed] PHST- 2026/05/18 06:49 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 10.3389/fped.2026.1724445 [doi] PST - epublish SO - Front Pediatr. 2026 May 1;14:1724445. doi: 10.3389/fped.2026.1724445. eCollection 2026. PMID- 42146861 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260928 IS - 2309-995X (Electronic) IS - 2076-4243 (Print) IS - 2076-4243 (Linking) VI - 18 IP - 2 DP - 2026 TI - Neural Network Technologies for Age Estimation in Children from Orthopantomograms (a Pilot Study). PG - 15-21 LID - 10.17691/stm2026.18.2.02 [doi] AB - The aim of the study was to investigate the potential of using artificial intelligence technologies for age estimation in children from dental radiographs. MATERIALS AND METHODS: A retrospective study was conducted, analyzing orthopantomograms of 322 children (173 female, 149 male) aged 4-16 years. Fourteen permanent mandibular teeth were annotated on each radiograph. Neural network training was performed by splitting the data into training and test sets at a ratio of 80:20; 5-fold cross-validation was used. Age estimation was approached as a regression task. The neural network training and validation were conducted in Python using the PyTorch library. The accuracy of age prediction was assessed using the coefficient of determination (R(2)), mean squared error (MSE), and mean absolute error (MAE). RESULTS: The study showed that the developed machine learning model was highly accurate in age estimation in children. The mean absolute error across cross-validation was 0.92 years, which was significantly lower than the error associated with traditional manual methods. FAU - Poletaeva, M P AU - Poletaeva MP AD - MD, PhD, Associate Professor, Department of Forensic Medicine, N.V. Sklifosovsky Institute of Clinical Medicine; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya St., Moscow, 119991, Russia. FAU - Vasilevsky, Yu V AU - Vasilevsky YV AD - DSc, Professor, Corresponding Member of the Russian Academy of Sciences, Head of the Department of Higher Mathematics, Mechanics, and Mathematical Modeling, Institute of Computer Science and Mathematical Modeling, Biomedical Science and Technology Park; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya St., Moscow, 119991, Russia. FAU - Valetov, D K AU - Valetov DK AD - Assistant, Department of Higher Mathematics, Mechanics, and Mathematical Modeling, Institute of Computer Science and Mathematical Modeling, Biomedical Science and Technology Park; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya St., Moscow, 119991, Russia. FAU - Angelakopoulos, N AU - Angelakopoulos N AD - DDS, MSc, Department of Orthodontics and Dentofacial Orthopaedics; University of Bern, 7 Freiburgstrasse, Bern, 3010, Switzerland. FAU - Zolotenkova, G V AU - Zolotenkova GV AD - MD, DSc, Professor, Department of Forensic Medicine, N.V. Sklifosovsky Institute of Clinical Medicine; I.M. Sechenov First Moscow State Medical University (Sechenov University), 8/2 Trubetskaya St., Moscow, 119991, Russia. LA - eng PT - Journal Article DEP - 20260430 PL - Russia (Federation) TA - Sovrem Tekhnologii Med JT - Sovremennye tekhnologii v meditsine JID - 101604515 SB - IM MH - Humans MH - Child MH - *Radiography, Panoramic/methods MH - *Age Determination by Teeth/methods MH - *Neural Networks, Computer MH - Female MH - Child, Preschool MH - Pilot Projects MH - Male MH - Adolescent MH - Retrospective Studies PMC - PMC13178086 OTO - NOTNLM OT - artificial neural network OT - deep learning OT - dental age estimation OT - dental status OT - medical imaging OT - orthopantomogram COIS- Study funding and conflict of interest. The study received no funding from any sources, and there are no conflicts of interest associated with this research. EDAT- 2026/05/18 12:43 MHDA- 2026/05/18 12:44 PMCR- 2026/01/01 CRDT- 2026/05/18 06:49 PHST- 2025/05/19 00:00 [received] PHST- 2026/05/18 12:44 [medline] PHST- 2026/05/18 12:43 [pubmed] PHST- 2026/05/18 06:49 [entrez] PHST- 2026/01/01 00:00 [pmc-release] AID - 10.17691/stm2026.18.2.02 [doi] PST - ppublish SO - Sovrem Tekhnologii Med. 2026;18(2):15-21. doi: 10.17691/stm2026.18.2.02. Epub 2026 Apr 30. PMID- 42146840 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260518 LR - 20260813 IS - 2325-9671 (Print) IS - 2325-9671 (Electronic) IS - 2325-9671 (Linking) VI - 14 IP - 5 DP - 2026 May TI - Validation of the ACL Return to Sport after Injury (ACL-RSI) Scale in Pediatric and Adolescent Patients After Medial Patellofemoral Ligament Reconstruction. PG - 23259671261426987 LID - 10.1177/23259671261426987 [doi] LID - 23259671261426987 AB - BACKGROUND: The Anterior Cruciate Ligament Return to Sport after Injury (ACL-RSI) scale assesses psychological readiness for return to sport (RTS) following anterior cruciate ligament reconstruction (ACLR). Although developed and validated in accordance with ACLR recovery, psychological responses may apply to those recovering from medial patellofemoral ligament reconstruction (MPFLR). PURPOSE: To validate the use of the ACL-RSI scale in pediatric and adolescent patients who underwent MPFLR. STUDY DESIGN: Cohort study (diagnosis); Level of evidence, 3. METHODS: Scores of the 12-item and shortened 6-item ACL-RSI for patients who underwent their first RTS readiness assessment after MPFLR were analyzed. Statistical analysis was performed using Spearman correlation for convergent validity testing against the International Knee Documentation Committee (IKDC)/Pediatric (Pedi-)IKDC score, Single Assessment Numeric Evaluation (SANE) score, and peak strength symmetry of knee extension and flexion. Discriminant validity testing was performed comparing ACL-RSI with age (Spearman correlation), body mass index (BMI) (Spearman correlation), and sex (Mann-Whitney U tests). Internal consistency reliability was tested using Cronbach alpha. Floor and ceiling effect testing was performed by calculating the proportion of minimum and maximum scores in the cohort. RESULTS: A total of 32 patients (59% female; mean age, 15.6 +/- 1.7 years) were included. Both 12-item and 6-item ACL-RSI scale versions demonstrated significant correlations of moderate to strong strength with the IKDC/Pedi-IKDC (R = 0.69 and R = 0.67, respectively; P < .001) and with the SANE score (R = 0.56 and R = 0.54, respectively; P = .002). Neither scale version was significantly correlated with peak strength symmetry of knee flexion or extension. Age, BMI, and sex were not significantly correlated with either scale. The 12-item ACL-RSI and 6-item short version demonstrated excellent internal reliability with a Cronbach alpha of .94 and .88, respectively, across individual items. No floor or ceiling effects were found with either scale as the minimum score, 0, was not observed and the maximum score, 100, was only observed twice in both versions (6%). CONCLUSION: The ACL-RSI scale may be valid for use in pediatric and adolescent patients who undergo MPFLR. Both the 12-item and the 6-item versions demonstrated convergent validity, discriminant validity, and internal reliability with no floor or ceiling effects. The 6-item scale version may be preferred, as it is able to quantify these vital psychological data but with minimal questionnaire burden and low redundancy. CI - (c) The Author(s) 2026. FAU - Matsuzaki, Yukiko AU - Matsuzaki Y AD - Hospital for Special Surgery, New York, New York, USA. FAU - Jones, Ruth H AU - Jones RH AUID- ORCID: 0009-0006-3097-0747 AD - Hospital for Special Surgery, New York, New York, USA. FAU - Tracey, Olivia C AU - Tracey OC AUID- ORCID: 0000-0002-3563-6696 AD - Hospital for Special Surgery, New York, New York, USA. FAU - Beber, Samuel A AU - Beber SA AUID- ORCID: 0009-0009-8477-9413 AD - Hospital for Special Surgery, New York, New York, USA. FAU - Adhiyaman, Akshitha AU - Adhiyaman A AD - Hospital for Special Surgery, New York, New York, USA. AD - Atlantic Health System-Morristown Medical Center, Morristown, New Jersey, USA. FAU - Lijesen, Emilie AU - Lijesen E AD - Hospital for Special Surgery, New York, New York, USA. AD - University of Florida College of Medicine, Gainesville, Florida, USA. Y.M. and R.H.J. are co-authors of this article. FAU - Propp, Bennett E AU - Propp BE AD - Hospital for Special Surgery, New York, New York, USA. FAU - Jones, Debi AU - Jones D AD - Hospital for Special Surgery, New York, New York, USA. FAU - Shubin Stein, Beth AU - Shubin Stein B AD - Hospital for Special Surgery, New York, New York, USA. FAU - Green, Daniel W AU - Green DW AUID- ORCID: 0000-0001-7286-6864 AD - Hospital for Special Surgery, New York, New York, USA. FAU - Fabricant, Peter D AU - Fabricant PD AUID- ORCID: 0000-0002-8070-685X AD - Hospital for Special Surgery, New York, New York, USA. LA - eng PT - Journal Article DEP - 20260512 PL - United States TA - Orthop J Sports Med JT - Orthopaedic journal of sports medicine JID - 101620522 PMC - PMC13172679 OTO - NOTNLM OT - ACL-RSI OT - MPFL reconstruction OT - pediatric OT - return to sport COIS- One or more of the authors has declared the following potential conflict of interest or source of funding: B.S.S. has received royalties from CONMED Corporation and educational support from Arthrex and is on the medical publishing board of AOSSM. D.W.G. has received hospitality payments from Orthopediatrics and is on the board of the Patellofemoral Foundation and the NY State Society of Orthopaedic Surgeons and is a consultant for Arthrex Inc. D.W.G. also receives royalties from Arthrex Inc. and faculty/speaker fees from Synthes. P.D.F. has received consulting fees from BICMD Inc and OssoVR and publishing royalties from Springer Nature; he serves as associate editor of Clinical Orthopedics and Related Research. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto. EDAT- 2026/05/18 12:43 MHDA- 2026/05/18 12:44 PMCR- 2026/05/12 CRDT- 2026/05/18 06:48 PHST- 2026/01/23 00:00 [received] PHST- 2026/02/06 00:00 [accepted] PHST- 2026/05/18 12:44 [medline] PHST- 2026/05/18 12:43 [pubmed] PHST- 2026/05/18 06:48 [entrez] PHST- 2026/05/12 00:00 [pmc-release] AID - 10.1177_23259671261426987 [pii] AID - 10.1177/23259671261426987 [doi] PST - epublish SO - Orthop J Sports Med. 2026 May 12;14(5):23259671261426987. doi: 10.1177/23259671261426987. eCollection 2026 May. PMID- 42146087 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260518 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Dietary intakes of cysteine, glutamate, proline, and tryptophan are associated with hypertension risk in Chinese children and adolescents: a national cross-sectional study integrating machine learning. PG - 1798822 LID - 10.3389/fnut.2026.1798822 [doi] LID - 1798822 AB - OBJECTIVE: The aim of the study was to examine the relationships between dietary intake of amino acids and the risk of hypertension and to find some important amino acids as the targets of intervention in Chinese children and adolescents. METHODS: The 2016-2019 China Children and Lactating Women Nutrition and Health Surveillance (CCLWNHS) was used to draw data and included 12,187 children and adolescents aged 6-18 years. A validated food frequency questionnaire (FFQ) was used to determine dietary intake with a weighing procedure. After the process of feature selection based on the Boruta algorithm, multivariate logistic regression was used to determine the relationships between amino acids and hypertension. The predictive performance was assessed through the development of XGBoost, LightGBM, NB and NN models. The SHapley Additive exPlanations (SHAP) approach was used to identify key features. Stratified analyses, interaction tests, and restricted cubic spline analyses were done as well. RESULTS: Cysteine, phenylalanine, histidine, glutamic acid, and proline were positively related to the risk of hypertension in the fully adjusted multivariate model (ORs: 2.000, 1.649, 1.387, 1.052, and 1.105, respectively), and threonine, valine, alanine, and tryptophan were negatively related (ORs: 0.587, 0.704, 0.809, and 0.516). LightGBM was the most successful predictive model (AUC = 0.793). SHAP analysis revealed that the core amino acids that affected the risk of hypertension were cysteine, glutamic acid, tryptophan, and proline. Sensitivity analyses showed that the relationships of these amino acids with hypertension were different in the subgroups based on age, sex, school type, physical activity level, and energy intake, and had a linear dose-response relationship. CONCLUSION: A greater intake of cysteine, glutamic acid and proline through the diet is linked to a higher risk of hypertension among Chinese children and adolescents but tryptophan is protective. Such results give a scientific foundation on the development of specific nutritional intervention programs and optimization of protein consumption to prevent early hypertension in life. CI - Copyright (c) 2026 Yu, Wang, Lv, Liu, Liu, Tian, Zhu, Tang and Chen. FAU - Yu, Lianlong AU - Yu L AD - Shandong Center for Disease Control and Prevention, Jinan, China. FAU - Wang, Hongwei AU - Wang H AD - Department of Health Care, People's Hospital of Rizhao, Rizhao, China. FAU - Lv, Zhimin AU - Lv Z AD - Department of Clinical Nutrition, People's Hospital of Rizhao, Rizhao, China. FAU - Liu, Changqing AU - Liu C AD - Hebei Center for Disease Control and Prevention, Shijiazhuang, China. FAU - Liu, Yiya AU - Liu Y AD - Guizhou Center for Disease Control and Prevention, Guiyang, China. FAU - Tian, Meina AU - Tian M AD - Hebei Center for Disease Control and Prevention, Shijiazhuang, China. FAU - Zhu, Qianrang AU - Zhu Q AD - Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China. FAU - Tang, Zhenchuang AU - Tang Z AD - Institute of Food and Nutrition Development, Ministry of Agriculture and Rural Affairs, Beijing, China. FAU - Chen, Yao AU - Chen Y AD - Department of Clinical Nutrition, People's Hospital of Rizhao, Rizhao, China. LA - eng PT - Journal Article DEP - 20260430 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13171856 OTO - NOTNLM OT - adolescents OT - children OT - dietary amino acids OT - hypertension OT - machine learning OT - national survey COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/18 12:43 MHDA- 2026/05/18 12:44 PMCR- 2026/04/30 CRDT- 2026/05/18 06:40 PHST- 2026/01/29 00:00 [received] PHST- 2026/03/28 00:00 [revised] PHST- 2026/04/07 00:00 [accepted] PHST- 2026/05/18 12:44 [medline] PHST- 2026/05/18 12:43 [pubmed] PHST- 2026/05/18 06:40 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - 10.3389/fnut.2026.1798822 [doi] PST - epublish SO - Front Nutr. 2026 Apr 30;13:1798822. doi: 10.3389/fnut.2026.1798822. eCollection 2026. PMID- 42145952 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Comparisons of kinanthropometric variables and physical performance in adolescent soccer players of different biological maturation. PG - e21203 LID - 10.7717/peerj.21203 [doi] LID - e21203 AB - Biological maturation is a crucial factor in the physical development of adolescent soccer players, affecting key performance-related variables essential for talent development. This study investigated differences across maturation stages in kinanthropometric and physical performance parameters in young male soccer players. Forty-three players (13.26 +/- 1.03 years) were classified into pre-, circa-, and post-peak height velocity (PHV) groups, with maturation status assessed using a validated AI-based method (China-05). Participants then completed a series of kinanthropometric assessments, including height, body mass, and body composition measured via dual-energy X-ray absorptiometry (DEXA). Additionally, they performed physical performance tests, which consisted of the countermovement jump (CMJ), isometric mid-thigh pull (IMTP), maximal oxygen uptake (VO(2max)) test, Wingate anaerobic test (WAT), 10-meter and 30-meter sprint times, and the Yo-Yo intermittent recovery test (Yo-Yo IR1). Results showed significant differences in fat mass and skeletal muscle mass, particularly between post- and pre-PHV players (p < 0.001), with post-PHV players exhibiting higher skeletal muscle mass. In terms of performance, the post-PHV group recorded significantly lower VO(2max) (p < 0.05) but higher CMJ heights (p < 0.001), while sprint times showed no significant variation across maturity stages (p > 0.05). Fatigue index and peak force also differed notably, with post-PHV players displaying higher fatigue levels and peak force (p < 0.001). Significant differences in IMTP impulse at 100 ms and 300 ms (p < 0.001) indicated greater strength and power with advanced maturation. These findings underscore the influence of biological maturation on kinanthropometric and physical performance metrics, linking advanced maturation with increased strength and power but reduced aerobic capacity in post-PHV players, likely due to greater body mass. The results highlight the need for tailored training programs that consider both chronological and biological age to optimize player development, supporting more effective talent identification and training strategies. CI - (c)2026 Wang et al. FAU - Wang, Rou AU - Wang R AD - Sports Coaching College, Beijing Sport University, Beijing, China. FAU - Liu, Meng AU - Liu M AD - Department of Physical Education, University of Jinan, Jinan, China. FAU - Nugent, Frank AU - Nugent F AD - Physical Education & Sport Sciences, University of Limerick, Limerick, Ireland. FAU - Kearney, Philip AU - Kearney P AD - Physical Education & Sport Sciences, University of Limerick, Limerick, Ireland. FAU - Ho, Indy Man Kit AU - Ho IMK AD - Faculty of Management and Hospitality, Technological and Higher Education Institute of Hong Kong, Hong Kong, China. AD - Faculty of Kinesiology, University of Zagreb, Zagreb, Croatia. FAU - Li, Cong AU - Li C AD - Facilitate Healthy Developments for Children (Hebei) Technology Co., Ltd., Shijiazhuang, Hebei, China. FAU - Pang, Hai AU - Pang H AD - Facilitate Healthy Developments for Children (Hebei) Technology Co., Ltd., Shijiazhuang, Hebei, China. FAU - Li, Weiming AU - Li W AD - Sports Coaching College, Beijing Sport University, Beijing, China. FAU - Xu, Yaohui AU - Xu Y AD - Sports Coaching College, Beijing Sport University, Beijing, China. FAU - Liu, Haochong AU - Liu H AD - Sports Coaching College, Beijing Sport University, Beijing, China. AD - Physical Education & Sport Sciences, University of Limerick, Limerick, Ireland. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260513 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - Male MH - *Soccer/physiology MH - Adolescent MH - *Athletic Performance/physiology MH - Body Composition MH - Oxygen Consumption/physiology MH - Absorptiometry, Photon MH - Muscle, Skeletal/physiology MH - Exercise Test MH - Anthropometry PMC - PMC13179742 OTO - NOTNLM OT - Development OT - Growth OT - Kinanthropometry OT - Performance OT - Puberty OT - Skeletal maturation COIS- Cong Li and Hai Pang are employed by Facilitate Healthy Developments for Children (Hebei) Technology Co., Ltd. The authors declare that no other competing interests exist. EDAT- 2026/05/18 12:42 MHDA- 2026/05/18 12:43 PMCR- 2026/05/13 CRDT- 2026/05/18 06:39 PHST- 2025/08/27 00:00 [received] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/05/18 12:43 [medline] PHST- 2026/05/18 12:42 [pubmed] PHST- 2026/05/18 06:39 [entrez] PHST- 2026/05/13 00:00 [pmc-release] AID - 21203 [pii] AID - 10.7717/peerj.21203 [doi] PST - epublish SO - PeerJ. 2026 May 13;14:e21203. doi: 10.7717/peerj.21203. eCollection 2026. PMID- 42145476 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Obesity and its relationship with lifestyle behaviors among Kuwaiti adolescents revisited after 15 years: a study protocol. PG - 1808837 LID - 10.3389/fpubh.2026.1808837 [doi] LID - 1808837 AB - BACKGROUND: Lifestyle behaviors such as physical activity, sedentary time, sleep, and dietary habits play a central role in shaping adolescent health. In Kuwait, the Arab Teens Lifestyle Study (ATLS), conducted in 2009/2010, reported that nearly half of adolescents were overweight or obese, with physical inactivity and unhealthy dietary patterns emerging as key correlates. Over the past 15 years, profound societal changes, including accelerated digitalisation and shifts in food environments, may have further altered these patterns, yet updated nationally representative data are lacking. OBJECTIVES: This study will reassess the prevalence of overweight, obesity, and lifestyle behaviors among Kuwaiti adolescents and directly compare findings with the 2009/2010 ATLS using the same methodological framework. For the first time in Kuwait, psychological wellbeing, grip strength, and objectively measured physical activity and sleep will also be assessed. METHODS: A school-based cross-sectional survey designed as a methodological revisit to the 2009/2010 ATLS will be conducted among a representative sample of 14-19-year-old students from public and private secondary schools across Kuwait using a multistage stratified cluster sampling design (target n approximately 1,320-1,350). Data collection will include standardized anthropometric measurements, validated questionnaires covering physical activity, sedentary behaviors, sleep, dietary habits, and psychological wellbeing, grip strength dynamometry, and wrist-worn accelerometery where funding permits. All inferential analyses will be conducted using survey-adjusted procedures accounting for the complex sampling design. EXPECTED OUTCOMES: This study will generate nationally representative, contemporary evidence on adolescent health behaviors in Kuwait, enable direct temporal comparisons with 2009/2010 baseline findings, and support the development of targeted public health strategies aimed at reducing obesity and improving the wellbeing of Kuwaiti adolescents. CI - Copyright (c) 2026 Alosaimi, Al-Farhan, Alkazemi and Al-Hazzaa. FAU - Alosaimi, Noura AU - Alosaimi N AD - Food and Nutrition Administration, Ministry of Health, Kuwait City, Kuwait. FAU - Al-Farhan, Abdulaziz Kh AU - Al-Farhan AK AD - Biomedical Science Department, College of Nursing, Public Authority for Applied Education and Training, Kuwait City, Kuwait. FAU - Alkazemi, Dalal U Z AU - Alkazemi DUZ AD - Department of Food Science and Nutrition, College of Life Sciences, Kuwait University, Sabah Al-Salem University, Kuwait City, Kuwait. FAU - Al-Hazzaa, Hazzaa M AU - Al-Hazzaa HM AD - Lifestyle and Health Research Center, Health Sciences Research Center, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. AD - School of Sport Sciences, University of Jordan, Amman, Jordan. LA - eng PT - Journal Article DEP - 20260501 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Adolescent MH - Kuwait/epidemiology MH - *Life Style MH - Female MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - *Obesity/epidemiology MH - Prevalence MH - Sedentary Behavior MH - Exercise MH - Sleep MH - *Health Behavior MH - *Adolescent Behavior MH - Surveys and Questionnaires PMC - PMC13176217 OTO - NOTNLM OT - Kuwait OT - accelerometry OT - adolescent OT - dietary habit OT - grip strength OT - obesity OT - physical activity OT - psychological health COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/18 12:43 MHDA- 2026/05/18 12:44 PMCR- 2026/05/01 CRDT- 2026/05/18 06:35 PHST- 2026/02/11 00:00 [received] PHST- 2026/03/06 00:00 [revised] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/05/18 12:44 [medline] PHST- 2026/05/18 12:43 [pubmed] PHST- 2026/05/18 06:35 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1808837 [doi] PST - epublish SO - Front Public Health. 2026 May 1;14:1808837. doi: 10.3389/fpubh.2026.1808837. eCollection 2026. PMID- 42145280 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260717 IS - 0035-7715 (Print) IS - 0035-7715 (Linking) VI - 76 IP - 4 DP - 2025 Dec 31 TI - Association of sweet taste perception and dietary habits with body mass index among public school children of Belagavi district, South India. PG - 315-322 LID - 220379 [pii] LID - 10.32394/rpzh/220379 [doi] AB - BACKGROUND: Healthy diet is significant for growth, development, and prevention from dietary related diseases in children and adults. Dietary imbalance can lead to many general and oral diseases and sugar rich diet can affect the teeth at an early age and continues towards adolescence causing several oral problems such as dental caries. Frequent consumption of a certain food causes changes in taste perception and leads to preference for that food. Taste perception may also be affected by several environmental, cultural, and genetic factors and has been found to be linked to oral health and body mass index (BMI). OBJECTIVE: This study evaluated the association between sweet taste perception, dietary habits, and body mass index among 13-15-year-old public school children in the Belagavi district. MATERIAL AND METHODS: A descriptive cross-sectional study was conducted among 1300 school children aged 13-15 years. Data were collected using a self-designed and validated questionnaire to assess dietary habits. Sweet taste perception was evaluated using sweet taste threshold (TT) and sweet taste preference (TP). Based on the sweet taste perception scores, participants were categorized into low, medium, and high groups. Body mass index was calculated using standard criteria. Descriptive statistics, Spearman's correlation test and ANOVA were performed. Statistical significance was considered for p-value /=2 vs 1 medicine, 95% CI [1.12-16.85], p = .034). A dose-response relationship was observed, with AKI odds increasing 4-fold per additional contaminated medicine (p-trend = .018). Promethazine oral solution showed strongest toxicity (aOR=4.15, 95% CI [1.15-15.82]), consistent with highest DEG concentration (19.4 mg/mL). Multivitamin effects were strongest in children <18 months (aOR=0.15, 95% CI [0.02-0.81]). Findings remained robust across propensity score-matched analyses. Study limitations include small sample size of resistant children (n = 16), potential recall bias, wide confidence intervals, and possible residual confounding of multivitamin associations by socioeconomic and health literacy factors. Substantial heterogeneity exists in pediatric DEG susceptibility. Younger age, polypharmacy with multiple contaminated products, and absence of multivitamin supplementation were independently associated with increased AKI risk. These findings suggest potential targets for risk stratification and prophylactic strategies, though observed multivitamin associations require prospective validation with attention to confounding before clinical implementation. CI - Copyright: (c) 2026 Barrow et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Barrow, Amadou AU - Barrow A AUID- ORCID: 0000-0002-6006-9355 AD - Department of Epidemiology, College of Public Health & Health Professions, College of Medicine, University of Florida, Gainesville, Florida, United States of America. AD - Department of Public & Environmental Health, School of Medicine & Allied Health Sciences, The University of the Gambia, Faraba Campus, Faraba, West Coast Region, The Gambia. FAU - Bittaye, Mustapha AU - Bittaye M AD - Edward Francis Small Teaching Hospital, Independence Drives, Banjul, The Gambia. AD - School of Medicine & Allied Health Sciences, The University of the Gambia, Independence Drives, Banjul, The Gambia. FAU - Bittaye, Sheikh Omar AU - Bittaye SO AUID- ORCID: 0000-0001-8162-7363 AD - Edward Francis Small Teaching Hospital, Independence Drives, Banjul, The Gambia. AD - School of Medicine & Allied Health Sciences, The University of the Gambia, Independence Drives, Banjul, The Gambia. FAU - Oguche, Sunday Musa AU - Oguche SM AD - Edward Francis Small Teaching Hospital, Independence Drives, Banjul, The Gambia. AD - School of Medicine & Allied Health Sciences, The University of the Gambia, Independence Drives, Banjul, The Gambia. LA - eng PT - Journal Article DEP - 20260515 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC13178974 COIS- The authors have declared that no competing interests exist. EDAT- 2026/05/15 18:33 MHDA- 2026/05/15 18:34 PMCR- 2026/05/15 CRDT- 2026/05/15 13:53 PHST- 2025/11/05 00:00 [received] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/05/15 18:34 [medline] PHST- 2026/05/15 18:33 [pubmed] PHST- 2026/05/15 13:53 [entrez] PHST- 2026/05/15 00:00 [pmc-release] AID - PGPH-D-25-03302 [pii] AID - 10.1371/journal.pgph.0005512 [doi] PST - epublish SO - PLOS Glob Public Health. 2026 May 15;6(5):e0005512. doi: 10.1371/journal.pgph.0005512. eCollection 2026. PMID- 42139221 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 5 DP - 2026 TI - Nutritional status and associated factors among hospitalized adult patients in comprehensive specialized hospitals of Western Ethiopia. PG - e0348796 LID - 10.1371/journal.pone.0348796 [doi] LID - e0348796 AB - BACKGROUND: Malnutrition is common among hospitalized patients but is often overlooked in low- and middle-income countries like Ethiopia. Therefore, this study aims to determine its prevalence and identify associated factors among adult patients admitted to comprehensive specialized hospitals in Western Ethiopia. METHODS: A facility-based cross-sectional study was conducted among 1,106 randomly selected adult patients admitted to comprehensive specialized hospitals from December 16, 2023 to April 16, 2024. The sample was proportionally allocated by patient population. Data were collected using Kobo Toolbox, then exported from Microsoft Excel to Stata version 17 for analysis. Nutritional status was assessed at admission using the Subjective Global Assessment (SGA). Ordinal logistic regression was applied after verifying the proportional odds assumption, with the Brant test used for model validation. Adjusted odds ratios (AORs) alongside 95% confidence intervals (CIs) were computed, and statistical significance was set at p < 0.05. RESULTS: Among all study participants, 24.5% (95% CI: 21.8%, 27.4%) were severely malnourished, while 34.4% (95% CI: 31.4%, 37.6%) were moderately malnourished. In the multivariable ordinal logistic regression analyses, factors significantly associated with both moderate and severe malnutrition included age greater or equal to 65 years [(AOR = 4.32; 95% CI: (2.02, 9.28)], age 41-64 years [(AOR = 3.36; (1.58, 7.16)], male sex [(AOR = 1.46,95% CI:(1.085,1.953)], urban residence [(AOR = 0.49; 95% CI: (0.32, 0.76)], lack of formal education [(AOR = 5.37; 95% CI: (3.32, 8.69)], comorbidities at admission [(AOR = 1.50;95%CI:(1.04,2.16)], and inadequate dietary diversity [(AOR = 1.37;95% CI:1.01,1.86)]. CONCLUSION: Malnutrition among hospitalized adult patients remains high and is strongly associated with age, sex, urban residence, educational status, comorbidities at admission, and dietary diversity. Therefore, hospital-based nutritional interventions should adopt a multidisciplinary approach, including early screening and identification, proper management of comorbidities, dietary counseling, and the development of comprehensive care plans and guidelines to improve clinical outcomes. CI - Copyright: (c) 2026 Moti et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Moti, Birtukan Kebede AU - Moti BK AUID- ORCID: 0000-0002-9365-8666 AD - Department of Public Health, Institute of Health Sciences, Wollega University, Nekemte, Ethiopia. FAU - Egata, Gudina AU - Egata G AD - Department of Nutrition & Dietetics, School of Public Health, College of Health Sciences, Addis Ababa University, Addis Ababa, Ethiopia. FAU - Tesso, Desalegn Wirtu AU - Tesso DW AD - Department of Public Health, Institute of Health Sciences, Wollega University, Nekemte, Ethiopia. LA - eng PT - Journal Article DEP - 20260515 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Ethiopia/epidemiology MH - Male MH - Female MH - Adult MH - *Nutritional Status MH - Middle Aged MH - *Malnutrition/epidemiology MH - Cross-Sectional Studies MH - *Hospitalization/statistics & numerical data MH - *Hospitals, Special MH - Aged MH - Young Adult MH - Prevalence MH - Adolescent MH - Risk Factors PMC - PMC13178860 COIS- The authors declare that they have no financial or non-financial competing interests. EDAT- 2026/05/15 18:33 MHDA- 2026/05/15 18:34 PMCR- 2026/05/15 CRDT- 2026/05/15 13:33 PHST- 2025/11/03 00:00 [received] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/05/15 18:34 [medline] PHST- 2026/05/15 18:33 [pubmed] PHST- 2026/05/15 13:33 [entrez] PHST- 2026/05/15 00:00 [pmc-release] AID - PONE-D-25-57131 [pii] AID - 10.1371/journal.pone.0348796 [doi] PST - epublish SO - PLoS One. 2026 May 15;21(5):e0348796. doi: 10.1371/journal.pone.0348796. eCollection 2026. PMID- 42138684 OWN - NLM STAT- MEDLINE DCOM- 20260929 LR - 20260929 IS - 2405-5018 (Electronic) IS - 2405-500X (Linking) VI - 12 IP - 9 DP - 2026 Sep TI - Epinephrine Challenge: Long-Term Evaluation of Test Performance for the Evaluation of Unexplained Cardiac Arrest and Familial Sudden Death. PG - 2251-2263 LID - S2405-500X(26)00318-X [pii] LID - 10.1016/j.jacep.2026.03.033 [doi] AB - BACKGROUND: The diagnostic implications of a positive epinephrine challenge for long QT syndrome (LQTS) or catecholaminergic polymorphic ventricular tachycardia (CPVT) are not well understood. Test interpretation is challenging, and false positives may be substantial. OBJECTIVES: This study sought to assess the test performance of epinephrine challenge for the diagnosis of LQTS and CPVT, utilizing long-term follow up. METHODS: The sensitivity, specificity, positive likelihood ratio (LR+), and negative likelihood ratio (LR-) of epinephrine challenge for the diagnosis of LQTS and CPVT were assessed in consecutive patients from the Hearts in Rhythm Organization registry, comparing to final working diagnosis according to guideline-derived diagnostic criteria, incorporating repeat phenotyping, and informed by targeted genetic testing over long-term follow-up. RESULTS: A total of 376 consecutive patients undergoing epinephrine challenge were followed for a mean duration of 8.6 +/- 5.3 years (250 patients with unexplained cardiac arrest [UCA] and 176 first-degree relatives). The sensitivity, specificity, LR+, and LR- of epinephrine for the diagnosis of LQTS, compared with final working diagnosis, were 90%, 79%, 4.4 (95% CI: 3.4-5.6), and 0.1 (95% CI: 0.0-0.4), respectively. QT prolongation with epinephrine demonstrated no significant correlation with end-recovery QTc on exercise stress testing. The sensitivity, specificity, LR+, and LR- of epinephrine for the diagnosis of CPVT, compared with final working diagnosis, were 62%, 93%, 8.9 (95% CI: 5.2-16.6), and 0.4 (95% CI: 0.2-0.8), respectively. A pathogenic LQTS variant was identified in only 15% of genotyped patients with a positive epinephrine challenge for LQTS, and a pathogenic CPVT variant in only 13% of patients with a positive epinephrine challenge for CPVT. Most patients with a positive epinephrine challenge for LQTS or CPVT had a "non-LQTS/CPVT" final working diagnosis (either UCA, unaffected, or an alternative Inherited arrhythmia syndrome). CONCLUSIONS: A positive epinephrine challenge demonstrated mild-moderate agreement with a final diagnosis of LQTS and CPVT. Most patients with an initial positive test result had their diagnosis revised to UCA, unaffected, or an alternative diagnosis over long-term follow-up. This study suggests that epinephrine challenge has limited utility as a "rule-in" test but may retain value in its negative predictive value for the UCA population. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Moore, Benjamin M AU - Moore BM AD - Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Steinberg, Christian AU - Steinberg C AD - Institut Universitaire de Cardiologie et Pneumologie de Quebec, Laval University, Quebec City, Quebec, Canada. FAU - Tadros, Rafik AU - Tadros R AD - Cardiovascular Genetics Center, Montreal Heart Institute, Montreal, Quebec, Canada. FAU - Cadrin-Tourigny, Julia AU - Cadrin-Tourigny J AD - Cardiovascular Genetics Center, Montreal Heart Institute, Montreal, Quebec, Canada. FAU - Chan, Douglas AU - Chan D AD - Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Davies, Brianna AU - Davies B AD - Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Laksman, Zachary W M AU - Laksman ZWM AD - Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Roberts, Jason D AU - Roberts JD AD - Population Health Research Institute, Hamilton, Ontario, Canada. FAU - Sanatani, Shubhayan AU - Sanatani S AD - Children's Heart Centre, BC Children's Hospital, Vancouver, British Columbia, Canada. FAU - MacIntyre, Ciorsti AU - MacIntyre C AD - Division of Cardiology, QEII Health Sciences Center, Halifax, Nova Scotia, Canada. FAU - Lee, David AU - Lee D AD - Division of Cardiology, QEII Health Sciences Center, Halifax, Nova Scotia, Canada. FAU - Green, Martin S AU - Green MS AD - University of Ottawa Heart Institute, Ottawa, Ontario, Canada. FAU - Khan, Habib R AU - Khan HR AD - Section of Cardiac Electrophysiology, Division of Cardiology, Department of Medicine, Western University, London, Ontario, Canada. FAU - Roston, Thomas M AU - Roston TM AD - Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Makanjee, Bhavanesh AU - Makanjee B AD - Heart Health Institute, Scarborough Health Network, Scarborough, Ontario, Canada. FAU - Ilhan, Erkan AU - Ilhan E AD - Libin Cardiovascular Institute, University of Calgary, Calgary, Alberta, Canada. FAU - Hansom, Simon AU - Hansom S AD - University of Ottawa Heart Institute, Ottawa, Ontario, Canada. FAU - Arbour, Laura AU - Arbour L AD - Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Seifer, Colette AU - Seifer C AD - Section of Cardiology, Department of Internal Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. FAU - Angaran, Paul AU - Angaran P AD - St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. FAU - Simpson, Christopher S AU - Simpson CS AD - Department of Medicine, Queen's University, Kingston, Ontario, Canada. FAU - Chauhan, Vijay S AU - Chauhan VS AD - Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada. FAU - Healey, Jeffrey S AU - Healey JS AD - Population Health Research Institute, Hamilton, Ontario, Canada. FAU - Krahn, Andrew D AU - Krahn AD AD - Division of Cardiology, Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: andrew.krahn@ubc.ca. LA - eng PT - Journal Article DEP - 20260514 PL - United States TA - JACC Clin Electrophysiol JT - JACC. Clinical electrophysiology JID - 101656995 RN - YKH834O4BH (Epinephrine) SB - IM MH - Humans MH - *Epinephrine MH - Female MH - Male MH - *Death, Sudden, Cardiac MH - *Long QT Syndrome/diagnosis/genetics MH - Adult MH - *Tachycardia, Ventricular/diagnosis/genetics MH - Sensitivity and Specificity MH - *Heart Arrest/diagnosis MH - Polymorphic Catecholaminergic Ventricular Tachycardia MH - Middle Aged MH - Electrocardiography MH - Follow-Up Studies MH - Adolescent MH - Young Adult OTO - NOTNLM OT - diagnosis OT - epinephrine challenge OT - sudden cardiac death OT - unexplained cardiac arrest COIS- Funding Support and Author Disclosures Dr Krahn has received support from the Paul Brunes Chair in Heart Rhythm Disorders (Vancouver, British Columbia, Canada). The study was supported by the Heart in Rhythm Organization (Dr Krahn, Principal Investigator) that receives support from the Canadian Institute of Health Research (RN380020-406814). The authors had full access to the data and take full responsibility for its integrity. All authors have read and agreed to the manuscript as written. The authors have reported that they have no relationships relevant to the contents of this paper to disclose. EDAT- 2026/05/15 17:36 MHDA- 2026/09/29 12:26 CRDT- 2026/05/15 10:28 PHST- 2025/12/17 00:00 [received] PHST- 2026/03/17 00:00 [revised] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/09/29 12:26 [medline] PHST- 2026/05/15 17:36 [pubmed] PHST- 2026/05/15 10:28 [entrez] AID - S2405-500X(26)00318-X [pii] AID - 10.1016/j.jacep.2026.03.033 [doi] PST - ppublish SO - JACC Clin Electrophysiol. 2026 Sep;12(9):2251-2263. doi: 10.1016/j.jacep.2026.03.033. Epub 2026 May 14. PMID- 42138210 OWN - NLM STAT- Publisher LR - 20260515 IS - 1748-3115 (Electronic) IS - 1748-3107 (Linking) DP - 2026 May 15 TI - Promoting healthy behaviours in young people with intellectual disabilities: a pilot RCT of an mHealth-based intervention targeting physical activity and sedentary behaviour. PG - 1-13 LID - 10.1080/17483107.2026.2671844 [doi] AB - Introduction and Purpose: Young individuals with intellectual disabilities (ID) often exhibit low levels of physical activity and high sedentary behaviour, increasing their risk of chronic health conditions. Digital health interventions may offer promising alternatives, although evidence in this population remains limited. This pilot randomised controlled trial (RCT) examined the effectiveness of a gamified mobile health (mHealth) intervention (IDHEApp) in promoting physical activity and reducing sedentary behaviour among youth with ID. Methods: 38 participants with ID (mean age = 20.4 years) were recruited in Rome (Italy) and Rijeka (Croatia) and randomised to an 8-week mHealth intervention or a control condition. Physical activity and sedentary behaviour were assessed using Fitbit Charge 6 devices. The intervention delivered daily gamified activity challenges and feedback tailored to users' cognitive needs. Effects were analysed using ANCOVA with post-intervention values as outcomes and baseline values as covariates, using complete-case analyses. Results: A significant between-group effect was observed for daily step count in favour of the intervention group (adjusted mean difference = 2,326.72 steps/day, 95% CI:763.97 to 3,461.23; p = 0.001; d = 0.97). No significant between-group effects were found for light, moderate, or vigorous physical activity, or for sitting and standing time; these outcomes were considered exploratory. Interaction analyses did not reveal differential effects between participants with Down syndrome and those with other forms of ID. Conclusion: This pilot RCT suggests that a gamified mHealth intervention is feasible and may increase daily ambulatory activity in young people with ID. Although effects were limited to step count, the findings provide hypothesis-generating evidence to inform future adequately powered trials in this underserved population. FAU - Sanudo, B AU - Sanudo B AD - Department of Physical Education and Sport, University of Seville, Seville, Spain. FAU - Sanudo, J I AU - Sanudo JI AD - Department of Physical Education and Sport, University of Seville, Seville, Spain. FAU - Feria, A AU - Feria A AD - Department of Physical Education and Sport, University of Seville, Seville, Spain. FAU - Schwarz, D AU - Schwarz D AD - Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany. FAU - Langbein, E AU - Langbein E AD - Department of Sport and Health Sciences, Technical University of Munich, Munich, Germany. FAU - Sanchez-Oliver, A J AU - Sanchez-Oliver AJ AD - Departamento de Motricidad Humana y Rendimiento Deportivo, University of Seville, Seville, Spain. LA - eng PT - Journal Article DEP - 20260515 PL - England TA - Disabil Rehabil Assist Technol JT - Disability and rehabilitation. Assistive technology JID - 101255937 SB - IM OAB - Gamified mHealth interventions may represent a feasible and acceptable strategy to support increases in daily ambulatory activity, such as step count, among young people with intellectual disabilities when appropriately adapted to their cognitive and communication needs.The observed between-group increase in daily step count suggests that digital tools could complement, rather than replace, traditional exercise- and rehabilitation-based approaches, particularly in real-world community and institutional settings.Although no statistically significant between-group effects were observed for sedentary behaviour or higher-intensity physical activity, wearable-supported monitoring may help raise awareness of daily movement patterns, highlighting these behaviours as relevant targets for future rehabilitation interventions.Exploratory analyses did not identify differential responses between participants with Down syndrome and those with other forms of intellectual disability; however, rehabilitation professionals should interpret these findings cautiously, as subgroup analyses were not powered to detect diagnostic-specific effects.To maximise feasibility and potential impact, mHealth-based rehabilitation interventions should prioritise user-centered design, accessible communication strategies, and caregiver or staff involvement, particularly to address barriers related to digital literacy, device management, and long-term engagement. OABL- eng OTO - NOTNLM OT - Intellectual disabilities OT - down syndrome OT - gamification OT - mHealth OT - physical activity OT - sedentary behaviour OT - wearable technology OT - youth EDAT- 2026/05/15 17:36 MHDA- 2026/05/15 17:36 CRDT- 2026/05/15 07:23 PHST- 2026/05/15 17:36 [medline] PHST- 2026/05/15 17:36 [pubmed] PHST- 2026/05/15 07:23 [entrez] AID - 10.1080/17483107.2026.2671844 [doi] PST - aheadofprint SO - Disabil Rehabil Assist Technol. 2026 May 15:1-13. doi: 10.1080/17483107.2026.2671844. PMID- 42138209 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1118-4841 (Print) IS - 1118-4841 (Linking) VI - 30 IP - 9 DP - 2026 May 15 TI - The social context of exclusive breastfeeding among mothers in Bulukumba, Indonesia: The role of the theory of planned behavior. PG - 88-99 LID - (Afr J Reprod Health 2026; 30 [9]:88-99). [pii] LID - 10.29063/ajrh2026/v30i9.8 [doi] AB - Exclusive breastfeeding is scientifically known to reduce child mortality; however, coverage remains low in Bulukumba Regency, which has the lowest rates in South Sulawesi Province, Indonesia. This study aimed to examine the influence of the Theory of Planned Behavior (TPB) on exclusive breastfeeding behavior among mothers in the region. A quantitative cross-sectional study was conducted with 161 mothers of infants aged 6-12 months. Data were collected using a validated and reliable questionnaire and analyzed using Structural Equation Modeling-Partial Least Squares (SEM-PLS). The findings indicate that maternal attitudes towards exclusive breastfeeding (beta=0.619) and perceived control (beta=0.338) had significantly positive effects on breastfeeding intention, whereas subjective norms were not significantly associated with breastfeeding intention (p=1.000). Furthermore, attitudes, subjective norms, perceived control, and intentions did not have a significant direct effect on exclusive breastfeeding behavior (p>0.05). The results highlight a gap between intention and actual breastfeeding practice, suggesting that strong intentions alone are insufficient to ensure exclusive breastfeeding. These findings underscore the importance of strengthening maternal attitudes and perceived control while addressing contextual and social barriers to behavior change. CI - African Journal of Reproductive Health (c) 2026. FAU - Idris, Fairus P AU - Idris FP AD - Department of Public Health, Faculty of Public Health, Universitas Muslim Indonesia, Indonesia. FAU - Sharief, Suchi A AU - Sharief SA AD - Department of Midwifery, Faculty of Public Health, Universitas Muslim Indonesia. FAU - Atmajaya, Dedy AU - Atmajaya D AD - Department of Informatics Engineering, Faculty of Computer Science, Universitas Muslim Indonesia, Indonesia3. FAU - Asrina, Andi AU - Asrina A AD - Department of Public Health, Faculty of Public Health, Universitas Muslim Indonesia, Indonesia. LA - eng PT - Journal Article PL - Nigeria TA - Afr J Reprod Health JT - African journal of reproductive health JID - 9712263 SB - IM MH - Humans MH - *Breast Feeding/psychology/statistics & numerical data/ethnology MH - Theory of Planned Behavior MH - Female MH - Indonesia MH - Cross-Sectional Studies MH - Infant MH - *Mothers/psychology MH - Adult MH - *Intention MH - Surveys and Questionnaires MH - *Health Knowledge, Attitudes, Practice MH - Young Adult OTO - NOTNLM OT - Maternal intention OT - behavioral determinant OT - infant feeding practice COIS- The Authors declared no conflict of interest EDAT- 2026/05/15 17:36 MHDA- 2026/05/15 17:37 CRDT- 2026/05/15 07:21 PHST- 2026/05/15 17:37 [medline] PHST- 2026/05/15 17:36 [pubmed] PHST- 2026/05/15 07:21 [entrez] AID - (Afr J Reprod Health 2026; 30 [9]:88-99). [pii] AID - 10.29063/ajrh2026/v30i9.8 [doi] PST - ppublish SO - Afr J Reprod Health. 2026 May 15;30(9):88-99. doi: 10.29063/ajrh2026/v30i9.8. PMID- 42138026 OWN - NLM STAT- Publisher LR - 20260515 IS - 1475-2700 (Electronic) IS - 0954-4224 (Linking) DP - 2026 May 15 TI - The validity of parent-report dietary assessment tools for estimating young children's intake of macronutrients and micronutrients: A systematic review. PG - 1-37 LID - 10.1017/S0954422426100456 [doi] AB - Obtaining accurate estimates of children's dietary intake is important because these estimates are used to characterize diet-disease relationships and inform nutrition interventions. This systematic review synthesized findings from validation studies of dietary assessment tools for children (aged 1-10 years), in which parents were proxy-reporters. Database searches (Ovid Medline, Embase, Web of Science, Cochrane) in January 2026 for validation studies of dietary assessment tools used for estimating daily intake of macronutrients and micronutrients yielded 4,545 citations. Articles were uploaded to Covidence for screening. Sixty-six articles met the inclusion criteria. Median sample size was 103. Eighty-six percent of studies (n=57) validated a food frequency questionnaire; the remainder validated dietary recalls (11%, n=8) or food diaries (2%, n=1). Many studies (67%, n=44) used another parent-proxy report tool as the reference method. For most nutrients, over a quarter of the 66 studies failed to find a significant correlation between the assessment tool and reference method. Among the 69% of analyses that did show a significant correlation, the median correlation for each nutrient ranged from 0.37 to 0.40 for macronutrients and 0.29 to 0.55 for micronutrients. Studies were limited by lack of generalizability, use of reference methods prone to error, and misalignment between the assessment tool and reference method. Overall, this review found no correlation or low-to-moderate correlations between dietary assessments and the reference method. The studies had significant methodological limitations. Future studies should validate parent-proxy report dietary assessments against objective measures, such as biomarkers. The development of novel assessment tools may also be warranted. FAU - Gomez Diaz Barreiro, Roberta AU - Gomez Diaz Barreiro R AD - Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO. FAU - Chehadeh, Fadia AU - Chehadeh F AD - Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO. FAU - Alderson, Bryce AU - Alderson B AD - Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO. FAU - Barbosa, Greg AU - Barbosa G AD - Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO. FAU - Carey, John AU - Carey J AD - Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO. FAU - Cohen, Catherine C AU - Cohen CC AD - Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO. FAU - Connell, Celeste P AU - Connell CP AD - Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO. FAU - Hollander, Christopher AU - Hollander C AD - Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO. FAU - Moding, Kameron J AU - Moding KJ AD - Department of Human Development & Family Science, Purdue University, West Lafayette, Indiana. FAU - Piper, Christi AU - Piper C AD - Strauss Health Sciences Library, University of Colorado Anschutz Medical Campus, Aurora, Colorado. FAU - Stamatoiu, Alexandra AU - Stamatoiu A AD - Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO. FAU - Zavala, Cindy I AU - Zavala CI AD - Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO. FAU - Bekelman, Traci A AU - Bekelman TA AUID- ORCID: 0000-0003-0840-1186 AD - Lifecourse Epidemiology of Adiposity and Diabetes (LEAD) Center, University of Colorado Anschutz Medical Campus, Aurora, CO. LA - eng PT - Journal Article PT - Review DEP - 20260515 PL - England TA - Nutr Res Rev JT - Nutrition research reviews JID - 9113797 SB - IM OTO - NOTNLM OT - children OT - nutrient intake OT - parent-proxy report OT - validation studies EDAT- 2026/05/15 06:29 MHDA- 2026/05/15 06:29 CRDT- 2026/05/15 05:42 PHST- 2026/05/15 06:29 [medline] PHST- 2026/05/15 06:29 [pubmed] PHST- 2026/05/15 05:42 [entrez] AID - S0954422426100456 [pii] AID - 10.1017/S0954422426100456 [doi] PST - aheadofprint SO - Nutr Res Rev. 2026 May 15:1-37. doi: 10.1017/S0954422426100456. PMID- 42138006 OWN - NLM STAT- MEDLINE DCOM- 20260603 LR - 20260813 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 May 15 TI - Defining and measuring food literacy in late childhood and adolescence: a scoping review. PG - e111 LID - 10.1017/S1368980026102651 [doi] LID - e111 AB - OBJECTIVE: Food literacy is a multidimensional concept capturing interrelated factors driving individuals' food behaviours. Conceptualisation to date has focused on adults without considering developmental limitations of childhood. This scoping review clarifies conceptualisation and measurement of food literacy in late childhood and adolescence. DESIGN: We searched the literature in seven electronic databases, following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews for article screening and selection. We conducted an inductive content analysis to identify the primary dimensions and indicators of food literacy for children and adolescents and examined assessment of these dimensions in existing measurement tools. SETTING: Articles covering late childhood and adolescent populations. PARTICIPANTS: Older children and adolescents (9-18 years). RESULTS: The initial search in November 2023 yielded 1319 articles with thirteen meeting inclusion criteria, and a search update in February 2026 yielded four additional recently published articles for inclusion. We identified four dimensions and twenty-three reflective indicators of child and adolescent food literacy. Conceptualisation and measurement of food literacy in children to date have heavily emphasised dimensions pertaining to food systems and nutrition knowledge and confidence in everyday food skills relative to valuing shared food experiences and purposeful engagement with food. CONCLUSIONS: Valuing shared food experiences and purposeful engagement with food are understudied dimensions of food literacy, despite evidence that they are important determinants of food behaviours. Future research should focus on further conceptual development and validation of age-appropriate indicators for these dimensions. FAU - St Pierre, Christine AU - St Pierre C AUID- ORCID: 0000-0003-1810-1777 AD - Department of Exercise and Nutrition Sciences, https://ror.org/00y4zzh67The George Washington University Milken Institute School of Public Health, USA. FAU - van Dam, Rob M AU - van Dam RM AD - Department of Exercise and Nutrition Sciences, https://ror.org/00y4zzh67The George Washington University Milken Institute School of Public Health, USA. FAU - Bingenheimer, Jeffrey B AU - Bingenheimer JB AD - Department of Prevention and Community Health, The George Washington University Milken Institute School of Public Health, USA. FAU - Sacheck, Jennifer M AU - Sacheck JM AD - Department of Exercise and Nutrition Sciences, https://ror.org/00y4zzh67The George Washington University Milken Institute School of Public Health, USA. AD - Department of Social and Behavioral Sciences, Brown University School of Public Health, USA. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260515 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Child MH - Adolescent MH - *Health Literacy MH - *Health Knowledge, Attitudes, Practice MH - *Feeding Behavior/psychology PMC - PMC13434494 OTO - NOTNLM OT - Adolescents OT - Children OT - Concept OT - Food literacy OT - Measurement indicators COIS- There are no conflicts of interest. EDAT- 2026/05/15 06:29 MHDA- 2026/06/03 18:36 PMCR- 2026/05/15 CRDT- 2026/05/15 05:33 PHST- 2026/06/03 18:36 [medline] PHST- 2026/05/15 06:29 [pubmed] PHST- 2026/05/15 05:33 [entrez] PHST- 2026/05/15 00:00 [pmc-release] AID - S1368980026102651 [pii] AID - 10.1017/S1368980026102651 [doi] PST - epublish SO - Public Health Nutr. 2026 May 15;29(1):e111. doi: 10.1017/S1368980026102651. PMID- 42137901 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260515 LR - 20260921 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 5 DP - 2026 May TI - Exploration of the Temporal Trends, Prevalence, and Factors of Acute Respiratory Infection or Diarrhoea: A Cross-Sectional Analysis of Three National Surveys. PG - e72529 LID - 10.1002/hsr2.72529 [doi] LID - e72529 AB - BACKGROUND AND AIMS: Numerous interventions have been targeted to reduce the burden of acute respiratory infection (ARI) and diarrhoea in Bangladesh. Both remain the leading causes of mortality in children under 5 (U5C). We aimed to examine the temporal trends, prevalence, and factors associated with ARI and diarrhoea using three nationally representative surveys. METHODS: We utilised data from three nationally representative surveys in Bangladesh: the Bangladesh Demographic and Health Survey (BDHS) 2017-2018, BDHS 2022, and the Multiple Indicator Cluster Survey (MICS) 2019. Analyses included the Cochran-Armitage test for trend, a multiple-adjusted binomial logistic regression model, slope and relative indices of inequality (RII), and the Mantel-Haenszel test with an approximate test of homogeneity of odds ratios. A p-value of < 0.05 was considered statistically significant. RESULTS: A total of 39,919 U5C were included for ARI and 39,875 U5C for diarrhoea. A downward, monotonic trend was observed in ARI prevalence from 3.1% in 2017-2018 to 1.4% in 2022. In contrast, diarrhoea prevalence increased from 4.9% in 2017-2018 to 6.9% in 2019 and declined to 4.8% in 2022. Male children were associated with higher odds of ARI (aOR: 1.37, 95% CI: 1.04-1.82), and younger children were associated with lower odds of diarrhoea (aOR: 0.97, 95% CI: 0.96-0.98 in 2017-2018). Relative inequality remained significant for both ARI (RII: 2.36 in 2017-2018) and diarrhoea (RII: 1.92 in 2022), indicating disparities across wealth groups. Heterogeneity across survey years was observed only for the association of underweight status and wealth index with diarrhoea. CONCLUSION: ARI prevalence declined by a 2.2-fold over 5 years, suggesting effectiveness of existing child health strategies, including immunisation and IMCI. Diarrhoea showed no consistent decline. Risk remained higher among male and younger children, with persistent socioeconomic inequalities. Steps should also be taken to consider wealth-related accessibility and feasibility for future policy-focused recommendations. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Ahmed, Mahdia AU - Ahmed M AD - Cornell University Ithaca New York USA. AD - Nutrition Research Division, icddr,b, Mohakhali Dhaka. FAU - Fidah, Md Fuad Al AU - Fidah MFA AUID- ORCID: 0000-0002-6695-6342 AD - Nutrition Research Division, icddr,b, Mohakhali Dhaka. AD - NIPSOM, Mohakhali Dhaka. FAU - Zaman, Mahabub Uz AU - Zaman MU AD - Nutrition Research Division, icddr,b, Mohakhali Dhaka. FAU - Islam, Md Ridwan AU - Islam MR AD - Nutrition Research Division, icddr,b, Mohakhali Dhaka. FAU - Ahmed, Tahmeed AU - Ahmed T AD - Nutrition Research Division, icddr,b, Mohakhali Dhaka. FAU - Mahfuz, Mustafa AU - Mahfuz M AD - Nutrition Research Division, icddr,b, Mohakhali Dhaka. LA - eng PT - Journal Article DEP - 20260513 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13169161 COIS- The authors declare no conflicts of interest. EDAT- 2026/05/15 06:29 MHDA- 2026/05/15 06:30 PMCR- 2026/05/13 CRDT- 2026/05/15 04:57 PHST- 2025/12/06 00:00 [received] PHST- 2026/04/06 00:00 [revised] PHST- 2026/05/07 00:00 [accepted] PHST- 2026/05/15 06:30 [medline] PHST- 2026/05/15 06:29 [pubmed] PHST- 2026/05/15 04:57 [entrez] PHST- 2026/05/13 00:00 [pmc-release] AID - HSR272529 [pii] AID - 10.1002/hsr2.72529 [doi] PST - epublish SO - Health Sci Rep. 2026 May 13;9(5):e72529. doi: 10.1002/hsr2.72529. eCollection 2026 May. PMID- 42137348 OWN - NLM STAT- MEDLINE DCOM- 20260918 LR - 20260918 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Postoperative serum oxidative stress measures in women with papillary thyroid cancer. PG - 1810839 LID - 10.3389/fendo.2026.1810839 [doi] LID - 1810839 AB - Papillary thyroid carcinoma (PTC) is the most common thyroid malignancy, with a steadily rising incidence worldwide and a marked female predominance. While prognosis is generally favorable, certain histopathological features, particularly angioinvasion, are associated with increased recurrence risk and reduced responsiveness to radioactive iodine (RAI) therapy. Emerging evidence implicates oxidative stress in thyroid tumorigenesis and progression, potentially influencing tumor aggressiveness. Given the higher disease burden in women and the potential influence of hormonal status on oxidative balance, this hypothesis-generating study focused exclusively on female patients to minimize hormonal variability and to explore associations between peripheral oxidative stress measures, DXA-derived body composition parameters, and angioinvasion as a feature of tumor aggressiveness in PTC. A total of 80 women were enrolled, including 36 with angioinvasive PTC, 15 with non-angioinvasive PTC, and 29 healthy controls. Blood samples were collected post-thyroidectomy. A broad panel of biochemical, hormonal, and oxidative stress markers including 3-nitrotyrosine (3-NT), 8-hydroxy-2'-deoxyguanosine (8-OHdG), malondialdehyde (MDA), protein carbonyls, 8-oxoguanine DNA glycosylase-1 (OGG1), and total antioxidant/oxidant capacity (TAS/TAC, TOS) was assessed. Among oxidative stress markers, OGG1 and MDA were significantly elevated in the PTC groups (both, p < 0.001). Additionally, android fat distribution and the android-to-gynoid fat ratio were significantly higher in the angioinvasive group (p = 0.03 and p = 0.01, respectively). Among the evaluated models, the panel combining MDA and TOS demonstrated the highest diagnostic performance (AUC = 0.83), suggesting its potential exploratory value for distinguishing angioinvasive from non-angioinvasive PTC in a postoperative setting. CI - Copyright (c) 2026 Buczynska-Backiel, Sidorkiewicz, Kosciuszko, Siewko, Poplawska-Kita, Rusak, Adamski, Dzieciol-Anikiej, Dzieciol, Szymczuk, Hady, Mysliwiec, Kretowski and Adamska. FAU - Buczynska-Backiel, Angelika AU - Buczynska-Backiel A AD - Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland. FAU - Sidorkiewicz, Iwona AU - Sidorkiewicz I AD - Clinical Research Support Centre, Medical University of Bialystok, Bialystok, Poland. FAU - Kosciuszko, Maria AU - Kosciuszko M AD - Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland. FAU - Siewko, Katarzyna AU - Siewko K AD - Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland. FAU - Poplawska-Kita, Anna AU - Poplawska-Kita A AD - Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland. FAU - Rusak, Malgorzata AU - Rusak M AD - Department of Haematological Diagnostics, Medical University of Bialystok, Bialystok, Poland. FAU - Adamski, Marcin AU - Adamski M AD - Faculty of Computer Science, Bialystok University of Technology, Bialystok, Poland. FAU - Dzieciol-Anikiej, Zofia AU - Dzieciol-Anikiej Z AD - Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland. AD - Department of Rehabilitation, Medical University of Bialystok, Bialystok, Poland. FAU - Dzieciol, Janusz AU - Dzieciol J AD - Department of Human Anatomy, Medical University of Bialystok, Bialystok, Poland. FAU - Szymczuk, Jaroslaw AU - Szymczuk J AD - 1st Clinical Department of General and Endocrine Surgery, Medical University of Bialystok, Bialystok, Poland. FAU - Hady, Hady Razak AU - Hady HR AD - 2nd Clinical Department of General and Gastroenterological Surgery, Medical University of Bialystok, Bialystok, Poland. FAU - Mysliwiec, Piotr AU - Mysliwiec P AD - 1st Clinical Department of General and Endocrine Surgery, Medical University of Bialystok, Bialystok, Poland. FAU - Kretowski, Adam Jacek AU - Kretowski AJ AD - Clinical Research Centre, Medical University of Bialystok, Bialystok, Poland. AD - Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland. FAU - Adamska, Agnieszka AU - Adamska A AD - Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Bialystok, Poland. LA - eng PT - Journal Article DEP - 20260429 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Biomarkers, Tumor) RN - EC 3.2.2.- (oxoguanine glycosylase 1, human) RN - 4Y8F71G49Q (Malondialdehyde) RN - 0 (Oxidants) RN - 0 (Antioxidants) RN - EC 3.2.2.- (DNA Glycosylases) SB - IM MH - Female MH - Humans MH - *Oxidative Stress/physiology MH - Postoperative Period MH - *Thyroid Cancer, Papillary/blood/surgery MH - *Thyroid Neoplasms/blood/surgery MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged MH - Aged MH - Thyroidectomy MH - *Biomarkers, Tumor/blood MH - Neoplasm Invasiveness/physiopathology MH - Malondialdehyde/blood MH - Predictive Value of Tests MH - Clinical Relevance MH - Oxidants/blood MH - Antioxidants/metabolism MH - DNA Glycosylases/blood MH - Body Composition/physiology MH - Neoplasm Recurrence, Local/etiology MH - Risk Assessment MH - Risk Factors PMC - PMC13167515 OTO - NOTNLM OT - 8-oxoguanine DNA glycosylase OT - ROC analysis OT - angioinvasion OT - lipid peroxidation OT - non-invasive biomarkers OT - oxidative stress OT - papillary thyroid cancer COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/15 06:29 MHDA- 2026/05/15 06:30 PMCR- 2026/04/29 CRDT- 2026/05/15 04:51 PHST- 2026/02/13 00:00 [received] PHST- 2026/03/31 00:00 [revised] PHST- 2026/04/06 00:00 [accepted] PHST- 2026/05/15 06:30 [medline] PHST- 2026/05/15 06:29 [pubmed] PHST- 2026/05/15 04:51 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - 10.3389/fendo.2026.1810839 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Apr 29;17:1810839. doi: 10.3389/fendo.2026.1810839. eCollection 2026. PMID- 42137006 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260515 LR - 20260813 IS - 2472-0054 (Electronic) IS - 2472-0054 (Linking) VI - 10 IP - 6 DP - 2025 Nov-Dec TI - Evidence-based Evaluation to Promote High-value Care in Pediatric Critical Care: It Is Time to Fully Adopt. PG - e863 LID - 10.1097/pq9.0000000000000863 [doi] LID - e863 AB - INTRODUCTION: Evidence-based recommendations for high-value care in pediatric critical care are needed. We sought to develop recommendations to identify unnecessary interventions, enhance outcomes, and promote efficient, patient-centered practices. METHODS: Using a modified Delphi process, a multi-institutional panel of pediatric intensivists from a national pediatric critical care quality improvement group identified 30 potential topics and selected 20 high- and medium-priority topics for further evaluation, and narrowed them to 10 by consensus voting. A structured scoping review of literature published between 2014 and 2023 identified 10 practices, which were critically assessed using the PICOST framework. The panel selected 5 priority recommendations based on evidence strength, feasibility, and potential impact. RESULTS: The panel developed 5 evidence-based recommendations: (1) prioritize early and progressive mobilization in the pediatric intensive care unit, (2) avoid reflexive culture testing in febrile children without clinical signs of infection, (3) conduct daily tracheal extubation readiness assessments to prevent unnecessary delays, (4) limit red blood cell transfusions in stable, nonbleeding patients with hemoglobin greater than 7 g/dL, and (5) initiate enteral nutrition within 48 hours when clinically safe and feasible. Each recommendation is grounded in current best evidence and aims to minimize harm while optimizing resource use and outcomes. CONCLUSIONS: Incorporating high-value care principles into pediatric critical care holds promise for reducing unwarranted variation, minimizing harm, and improving the efficiency and effectiveness of care. Future efforts should focus on implementation strategies, practice integration, and ongoing evaluation to sustain improvements and close the gap between evidence and adoption. CI - Copyright (c) 2025 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Dewan, Maya AU - Dewan M AD - Division of Critical Care Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio. FAU - Basu, Rajit K AU - Basu RK AD - Division of Critical Care Medicine, Department of Pediatrics, Ann & Robert Lurie Children's Hospital of Chicago, Feinberg School of Medicine, Northwestern University, Chicago, Ill. FAU - Bennett, Erin AU - Bennett E AD - Division of Critical Care Medicine, Department of Pediatrics, University of Arkansas for Medical Sciences, Arkansas Children's Hospital, Little Rock, Ark. FAU - Glater-Welt, Lily B AU - Glater-Welt LB AD - Department of Pediatrics, Division of Critical Care, Zucker School of Medicine, Cohen Children's Medical Center, New Hyde Park, N.Y. FAU - Hall, Mark AU - Hall M AD - Department of Pediatrics, Division of Critical Care Medicine, Nationwide Children's Hospital, Columbus, Ohio. FAU - Hsu, Benson S AU - Hsu BS AD - Department of Pediatrics, University of South Dakota Sanford School of Medicine, Sioux Falls, S.Dak. FAU - Lowrie, Lia AU - Lowrie L AD - Division of Critical Care Medicine, Department of Pediatrics, Saint Louis University School of Medicine, SSM Health Cardinal Glennon Children's Hospital, St. Louis, Mo. FAU - Pinto, Venessa Lynn AU - Pinto VL AD - Division of Critical Care Medicine, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Tex. FAU - Rotta, Alexandre T AU - Rotta AT AD - Division of Pediatric Critical Care Medicine, Duke University Medical Center, Durham, N.C. FAU - Seferian, Edward AU - Seferian E AD - Department of Anesthesiology and Critical Care Medicine, The Johns Hopkins Hospital, The Johns Hopkins University School of Medicine, Baltimore, Md. FAU - Siegel, Linda AU - Siegel L AD - Department of Pediatrics, Division of Critical Care, Zucker School of Medicine, Cohen Children's Medical Center, New Hyde Park, N.Y. FAU - Wolfe, Heather A AU - Wolfe HA AD - Division of Anesthesiology and Critical Care Medicine, The Children's Hospital of Philadelphia, University of Pennsylvania Perlman School of Medicine, Philadelphia, Pa. FAU - Srinivasan, Vijay AU - Srinivasan V AD - Division of Pediatric Critical Care Medicine, Department of Pediatrics, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Ga. LA - eng PT - Journal Article DEP - 20251223 PL - United States TA - Pediatr Qual Saf JT - Pediatric quality & safety JID - 101702480 PMC - PMC13169143 EDAT- 2026/05/15 06:29 MHDA- 2026/05/15 06:30 PMCR- 2025/12/23 CRDT- 2026/05/15 04:48 PHST- 2025/06/09 00:00 [received] PHST- 2025/12/02 00:00 [accepted] PHST- 2026/05/15 06:30 [medline] PHST- 2026/05/15 06:29 [pubmed] PHST- 2026/05/15 04:48 [entrez] PHST- 2025/12/23 00:00 [pmc-release] AID - PQS-D-25-00067 [pii] AID - 10.1097/pq9.0000000000000863 [doi] PST - epublish SO - Pediatr Qual Saf. 2025 Dec 23;10(6):e863. doi: 10.1097/pq9.0000000000000863. eCollection 2025 Nov-Dec. PMID- 42136614 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Associations between exercise motivation and self-efficacy through leisure satisfaction and psychological resilience in college students: a PLS-SEM study. PG - 1763971 LID - 10.3389/fpubh.2026.1763971 [doi] LID - 1763971 AB - OBJECTIVE: Growing concern has emerged regarding the mental health of young adults, particularly within university settings where academic and psychosocial pressures are prominent. Exercise motivation (EM), conceptualized within self-determination theory (SDT), especially intrinsic and identified regulation, has been associated with psychological well-being. However, the structural associations among exercise motivation (EM), leisure satisfaction (LS), psychological resilience (PR), and self-efficacy (SE) in young adults remain insufficiently clarified. METHODS: This cross-sectional study examined these associations in a sample of 437 university students aged 18-23 years in China. Data were collected through validated self-report instruments and analyzed using partial least squares structural equation modeling (PLS-SEM). RESULTS: The results indicated that exercise motivation was positively associated with leisure satisfaction (beta = 0.794, p < 0.001), leisure satisfaction was positively associated with psychological resilience (beta = 0.342, p < 0.001), and PR was positively associated with self-efficacy (beta = 0.228, p < 0.001). Sequential mediation analysis showed that leisure satisfaction and PR jointly accounted for a significant indirect association between EM and SE (beta = 0.062, p = 0.001). Model fit indices (SRMR = 0.055; NFI = 0.847) indicated an acceptable level of fit within the prediction-oriented PLS-SEM approach. CONCLUSION: These findings indicate that exercise motivation is statistically associated with psychological resources among young adults. Although causal inferences cannot be drawn due to the cross-sectional design, the study contributes to understanding motivational processes within the SDT framework and provides directions for future longitudinal research. CI - Copyright (c) 2026 Li, Ye, Yuan, Dong and Yan. FAU - Li, Taiping AU - Li T AD - Guangdong University of Science and Technology, Dongguan, Guangdong, China. FAU - Ye, Qiuxian AU - Ye Q AD - Zhuhai College of Science and Technology, Zhuhai, Guangdong, China. FAU - Yuan, Yafei AU - Yuan Y AD - Army Special Operations College, Guilin, Guangxi, China. FAU - Dong, Jifeng AU - Dong J AD - Guangdong University of Science and Technology, Dongguan, Guangdong, China. FAU - Yan, Yanqing AU - Yan Y AD - Guangdong University of Science and Technology, Dongguan, Guangdong, China. LA - eng PT - Journal Article DEP - 20260429 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Motivation MH - Cross-Sectional Studies MH - *Self Efficacy MH - Female MH - Young Adult MH - Male MH - *Personal Satisfaction MH - *Resilience, Psychological MH - *Students/psychology/statistics & numerical data MH - *Exercise/psychology MH - Adolescent MH - *Leisure Activities/psychology MH - China MH - Universities PMC - PMC13168066 OTO - NOTNLM OT - exercise motivation OT - leisure satisfaction OT - mood disorders OT - psychological resilience OT - self-efficacy OT - young adults COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/15 06:29 MHDA- 2026/05/15 06:30 PMCR- 2026/04/29 CRDT- 2026/05/15 04:43 PHST- 2025/12/09 00:00 [received] PHST- 2026/03/01 00:00 [revised] PHST- 2026/04/13 00:00 [accepted] PHST- 2026/05/15 06:30 [medline] PHST- 2026/05/15 06:29 [pubmed] PHST- 2026/05/15 04:43 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1763971 [doi] PST - epublish SO - Front Public Health. 2026 Apr 29;14:1763971. doi: 10.3389/fpubh.2026.1763971. eCollection 2026. PMID- 42136603 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Challenges, salutogenic resources and adolescent agency: a qualitative study in a public school in Peru. PG - 1824105 LID - 10.3389/fpubh.2026.1824105 [doi] LID - 1824105 AB - INTRODUCTION: Adolescents living in socioeconomically vulnerable environments face multiple interrelated academic, emotional, relational, and economic challenges that shape their well-being and development. Research has largely prioritised risk-based and adult-centred perspectives, often overlooking adolescents' capacities and strengths. This study explored how adolescents in a Peruvian public school perceive daily challenges, mobilise General Resistance Resources (GRRs), and exercise agency from a salutogenic perspective. METHODS: A qualitative study was conducted in a public secondary school in Acobamba, Peru. Twenty-eight adolescents (21 females and 7 males) and 6 teachers participated. Data were collected through month-long personal diaries, adolescent focus groups, and semi-structured interviews with teachers. A reflective thematic analysis was applied with equal rigour to adolescent and teacher data, enabling comparative analysis. Coding was inductive and supported by ATLAS.ti, integrating gender and salutogenesis as analytical lenses. RESULTS: Adolescents identified academic, relational, economic, family, and everyday challenges. They mobilised diverse GRRs (personal, social, spiritual, digital, and institutional) for emotional regulation, problem-solving, and meaning-making. Agency emerged as a dynamic context-dependent capacity shaped by the perceived impact of challenges and available resources, consistent with bounded agency. Gender differences were observed in the recognition of challenges, resources, and agency. Teachers recognised some resources and emerging agency in adolescents however emphasised risk, dependency, and limited autonomy, contrasting with adolescents' more active accounts. CONCLUSION: Adolescent well-being reflects the interaction between structural conditions, relational contexts, and resource mobilisation. Resources must be recognised, activated, and socially validated within a constrained agency. Bridging the gap between adolescent and adult perspectives is essential. Health promotion should strengthen adolescent capacities, address structural barriers, and incorporate gender and contextual perspectives. CI - Copyright (c) 2026 Guevara-Cabello, Huamancayo, Juvinya-Canal and Reig-Garcia. FAU - Guevara-Cabello, Maricela M AU - Guevara-Cabello MM AD - Doctoral Program in Molecular Biology, Biomedicine and Health, Universitat de Girona, Girona, Catalonia, Spain. FAU - Huamancayo, Bily Vargas AU - Huamancayo BV AD - Faculty of Science and Engineering, School of Nutrition, Universidad Peruana Cayetano Heredia, Lima, Peru. FAU - Juvinya-Canal, Dolors AU - Juvinya-Canal D AD - Nursing Department, Research Group on Health and Healthcare, University of Girona, Girona, Catalonia, Spain. FAU - Reig-Garcia, Gloria AU - Reig-Garcia G AD - Nursing Department, Research Group on Health and Healthcare, University of Girona, Girona, Catalonia, Spain. LA - eng PT - Journal Article DEP - 20260429 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Peru MH - Female MH - Adolescent MH - Male MH - *Schools MH - Qualitative Research MH - Sense of Agency MH - Focus Groups MH - Interviews as Topic PMC - PMC13170679 OTO - NOTNLM OT - adolescence OT - agency OT - daily challenges OT - general resistance resources OT - health promotion OT - salutogenesis COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/15 06:29 MHDA- 2026/05/15 06:30 PMCR- 2026/04/29 CRDT- 2026/05/15 04:43 PHST- 2026/03/05 00:00 [received] PHST- 2026/03/29 00:00 [revised] PHST- 2026/04/15 00:00 [accepted] PHST- 2026/05/15 06:30 [medline] PHST- 2026/05/15 06:29 [pubmed] PHST- 2026/05/15 04:43 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1824105 [doi] PST - epublish SO - Front Public Health. 2026 Apr 29;14:1824105. doi: 10.3389/fpubh.2026.1824105. eCollection 2026. PMID- 42136168 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 2239-253X (Electronic) IS - 0003-469X (Linking) VI - 97 IP - 5 DP - 2026 May 10 TI - Factors Influencing Wound Complications After Cesarean Section in Women With Gestational Diabetes Mellitus: Development and Validation of a Prediction Model. PG - 885-894 LID - 10.62713/aic.4468 [doi] AB - AIM: To investigate factors influencing wound complications after cesarean section in women with gestational diabetes mellitus (GDM) and to develop a predictive model. METHODS: A retrospective study was conducted, including 600 women with GDM who underwent cesarean delivery at The Maternal and Child Health Care Hospital of Tongxiang between January 2022 and February 2025. Participants were randomly divided into a training set (n = 420) and a validation set (n = 180) at a 7:3 ratio. Clinical variables for model development included age, body mass index (BMI), hypertension status, glycated hemoglobin (HbA1c), albumin level, and time to first postoperative ambulation. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors and establish the predictive model. The discriminative performance of the model was evaluated using the receiver operating characteristic (ROC) curve, while calibration curves and decision curve analysis (DCA) were applied to evaluate calibration and clinical utility, respectively. RESULTS: Wound complications occurred in 108 patients (18%). Multivariate analysis identified concurrent hypertension (odds ratio (OR) = 2.63, 95% CI: 1.30-5.33), elevated BMI (OR = 1.07, 95% CI: 1.01-1.15), increased HbA1c (OR = 1.76, 95% CI: 1.34-2.33), decreased albumin level (OR = 0.84, 95% CI: 0.78-0.91), and delayed time to first ambulation (OR = 1.17, 95% CI: 1.07-1.28) as independent risk factors for wound complications (all p < 0.05). The multivariable logistic regression model demonstrated good discrimination, with an area under the curve (AUC) of 0.78 (95% CI: 0.72-0.83) in the training set and 0.78 (95% CI: 0.69-0.87) in the validation set. Calibration and decision curve analyses indicated good agreement and clinical net benefit. CONCLUSIONS: This study developed and internally validated a predictive model incorporating five readily available clinical indicators. The model may assist in identifying women with GDM at increased risk of poor incision outcomes following cesarean section and support risk stratification and early clinical decision-making. CI - (c) Copyright: (c) 2026 The Author(s). FAU - Lu, Juefei AU - Lu J AD - Department of Obstetrics, The Maternal and Child Health Care Hospital of Tongxiang, 314500 Jiaxing, Zhejiang, China. FAU - Gao, Caifen AU - Gao C AD - Department of Obstetrics, The Maternal and Child Health Care Hospital of Tongxiang, 314500 Jiaxing, Zhejiang, China. LA - eng PT - Journal Article PT - Validation Study PL - Italy TA - Ann Ital Chir JT - Annali italiani di chirurgia JID - 0372343 RN - 0 (Glycated Hemoglobin) SB - IM MH - Humans MH - Female MH - *Diabetes, Gestational/blood MH - Pregnancy MH - *Cesarean Section/adverse effects MH - Retrospective Studies MH - Adult MH - Risk Factors MH - Glycated Hemoglobin/analysis MH - ROC Curve MH - Body Mass Index MH - Prediction Algorithms MH - *Surgical Wound Infection/etiology/epidemiology MH - Hypertension/complications/epidemiology MH - Logistic Models MH - *Postoperative Complications/etiology/epidemiology OTO - NOTNLM OT - cesarean section OT - gestational diabetes mellitus OT - nomogram OT - risk prediction OT - wound complications EDAT- 2026/05/15 06:30 MHDA- 2026/05/15 06:31 CRDT- 2026/05/15 02:43 PHST- 2025/12/04 00:00 [received] PHST- 2026/03/24 00:00 [revised] PHST- 2026/03/26 00:00 [accepted] PHST- 2026/05/15 06:31 [medline] PHST- 2026/05/15 06:30 [pubmed] PHST- 2026/05/15 02:43 [entrez] AID - S0003-469X(26)00089-0 [pii] AID - 10.62713/aic.4468 [doi] PST - ppublish SO - Ann Ital Chir. 2026 May 10;97(5):885-894. doi: 10.62713/aic.4468. PMID- 42136148 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260820 IS - 1471-0528 (Electronic) IS - 1470-0328 (Print) IS - 1470-0328 (Linking) VI - 133 IP - 10 DP - 2026 Sep TI - Phenotyping Preeclampsia Using Unsupervised Machine Learning: A Prospective Cohort Study. PG - 1926-1936 LID - 10.1111/1471-0528.70262 [doi] AB - OBJECTIVE: To explore clinically meaningful phenotypes of preeclampsia using unsupervised machine learning. DESIGN: Prospective cohort study. SETTING: BCNatal, a tertiary maternal-foetal medicine centre (Barcelona, Spain). POPULATION: A total of 482 pregnant women diagnosed with preeclampsia between August 2013 and April 2024. METHODS: Maternal demographic, clinical, ultrasound and laboratory data were prospectively collected, together with delivery details and maternal and neonatal complications. We generated a patient representation using maternal age, height, weight, body-mass index, blood pressure, angiogenic factors, urinary albumin/creatinine ratio, gestational age at birth and birthweight centile. Dimensionality reduction was performed using Uniform Manifold Approximation and Projection, followed by k-means clustering to identify phenotypes. MAIN OUTCOME MEASURES: Maternal and neonatal characteristics and complication rates were compared across clusters to evaluate the clinical significance of the data-driven phenotypes. RESULTS: Three phenotypes were identified. Cluster A (n = 223; 46.2%) showed earlier delivery (mean 33.1 +/- SD 3.3 weeks), marked angiogenic imbalance, prevalent foetal growth restriction (64%) and the highest rates of maternal (23%) and neonatal (41%) complications. Cluster B (n = 147; 30.5%) had later delivery (37.0 +/- 2.1 weeks), moderate angiogenic imbalance and intermediate birthweight centiles (15.5 +/- 9.7). Cluster C (n = 112; 23.2%) comprised mostly term cases (38.2 +/- 1.5 weeks) with the lowest angiogenic imbalance and the highest birthweight centile (67.9 +/- 27.3); obesity (31%) and diabetes (15%) were most prevalent and maternal (4%) and neonatal (9%) complications were least frequent. CONCLUSIONS: Unsupervised learning delineated three preeclampsia phenotypes. These phenotypes could support the need for future risk stratification and more personalised management; prospective external validation is warranted. CI - (c) 2026 The Author(s). BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd. FAU - Houri, Ohad AU - Houri O AUID- ORCID: 0000-0002-3393-813X AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain. FAU - Youssef, Lina AU - Youssef L AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain. FAU - Crovetto, Francesca AU - Crovetto F AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain. AD - Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin RD21/0012/0003, Instituto de Salud Carlos III, Madrid, Spain. FAU - Borrell, Maria AU - Borrell M AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain. FAU - Crimella, Maddalena AU - Crimella M AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain. FAU - Ferrante, Maria Giulia AU - Ferrante MG AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain. FAU - Novoa, Rommy H AU - Novoa RH AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain. FAU - Casas, Irene AU - Casas I AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain. FAU - Encabo, Noelia AU - Encabo N AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain. FAU - Benitez, Leticia AU - Benitez L AUID- ORCID: 0000-0002-4950-036X AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain. FAU - Larroya, Marta AU - Larroya M AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain. AD - Dexeus Mujer (Hospital Universitari Dexeus), Barcelona, Spain. FAU - Peguero, Anna AU - Peguero A AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain. FAU - Meler, Eva AU - Meler E AUID- ORCID: 0000-0002-5975-9834 AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain. FAU - Castro-Barquero, Sara AU - Castro-Barquero S AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Madrid, Spain. FAU - Bijnens, Bart AU - Bijnens B AD - BCN Medtech, Department of Information and Communication Technologies, Universitat Pompeu Fabra, Barcelona, Spain. AD - ICREA, Barcelona, Spain. FAU - Figueras, Francesc AU - Figueras F AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain. FAU - Gratacos, Eduard AU - Gratacos E AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain. AD - Centre for Biomedical Research on Rare Diseases (CIBERER), Barcelona, Spain. FAU - Bernardino, Gabriel AU - Bernardino G AD - ICREA, Barcelona, Spain. FAU - Crispi, Fatima AU - Crispi F AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), IDIBAPS, University of Barcelona, Barcelona, Spain. AD - Centre for Biomedical Research on Rare Diseases (CIBERER), Barcelona, Spain. LA - eng GR - 2021-SGR-01422/Departament de Recerca i Universitats de la Generalitat de Catalunya/ GR - PI22/00684/Instituto de Salud Carlos III/ GR - PI22/00109/Instituto de Salud Carlos III/ GR - PI24/00127/Instituto de Salud Carlos III/ GR - CM23/00118/Instituto de Salud Carlos III/ GR - CM21/00058/Instituto de Salud Carlos III/ GR - CD24/00244/Instituto de Salud Carlos III/ GR - INT25/00064/Instituto de Salud Carlos III/ GR - European Union/ GR - AP180722022/Fundacio Mutua Madrilena/ GR - AP16002/2024/Fundacio Mutua Madrilena/ GR - 202415-30-31/Fundacio La Marato de TV3/ GR - 82/257/Fundacio La Marato de TV3/ GR - BITRECS fellowship programme/ GR - LCF/PR/SP23/52950012/'la Caixa' Foundation/ GR - Fundacion Alfonso Martin Escudero/ GR - FSE+/ GR - RYC2022-035960-I/Agencia Estatal de investigacion/ GR - PID2023-149959OA-100/Agencia Estatal de investigacion/ GR - MICIU/AEI/10.13039/501100011033/ GR - Hospita Clinic Barcelona (Intensificacio Interna)/ GR - Fundacio Occident, Spain/ PT - Journal Article DEP - 20260514 PL - England TA - BJOG JT - BJOG : an international journal of obstetrics and gynaecology JID - 100935741 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Pre-Eclampsia/epidemiology/diagnosis MH - Prospective Studies MH - *Phenotype MH - *Unsupervised Machine Learning MH - Adult MH - Clustering Algorithms MH - Gestational Age MH - Spain/epidemiology MH - Infant, Newborn MH - Birth Weight PMC - PMC13485454 OTO - NOTNLM OT - cluster analysis OT - preeclampsia OT - pregnancy complications OT - unsupervised machine learning COIS- The authors declare no conflicts of interest. EDAT- 2026/05/15 06:29 MHDA- 2026/08/18 23:36 PMCR- 2026/08/18 CRDT- 2026/05/15 02:33 PHST- 2026/04/14 00:00 [revised] PHST- 2025/10/31 00:00 [received] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/08/18 23:36 [medline] PHST- 2026/05/15 06:29 [pubmed] PHST- 2026/05/15 02:33 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - BJO70262 [pii] AID - 10.1111/1471-0528.70262 [doi] PST - ppublish SO - BJOG. 2026 Sep;133(10):1926-1936. doi: 10.1111/1471-0528.70262. Epub 2026 May 14. PMID- 42136086 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260827 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 3 DP - 2026 Jul TI - Feasibility and Acceptability of a Breastfeeding Support Intervention Among Mothers of Infants Under Six Months Old Discharged From Malnutrition Treatment in Kilifi County. PG - e70202 LID - 10.1111/mcn.70202 [doi] LID - e70202 AB - Malnourished infants under 6 months experience poor growth and development. A pilot study applied the WHO guideline for treatment of acute malnutrition and found that it was possible to re-establish exclusive breastfeeding during inpatient treatment. However, weight gain could not be sustained 6 weeks after discharge suggesting that follow-up breastfeeding support may be required. Our study aimed to pilot the feasibility and acceptability of a follow-up intervention among infants discharged from malnutrition treatment. A home-based post-discharge breastfeeding support intervention was developed to be delivered by breastfeeding peer supporters in a series of three home visits and three intervention phone calls over a period of 7 weeks after discharge from the hospital. The intervention was piloted among 20 mother-infant pairs providing quantitative and qualitative data from a standardized questionnaire and in-depth interviews. Data was analyzed descriptively and using thematic analysis. The median infant birth weight was 2.07 kg and > 50% of the mothers had primary education or less. The intervention was feasible with 100% reach of the target participants with a geographic spread of 25% urban and 75% rural areas. All intervention components were applied consistently, resulting in 100% adherence over a 6-month period. The intervention was accepted by mothers, perceived to be beneficial, and reported to increase breastfeeding confidence. It was adaptable, adjusting to emerging challenges, and was successfully integrated into existing health services. The pilot demonstrated high feasibility and widespread acceptance of the intervention. Its effectiveness to improve weight gain among recovering infants is being determined in a trial. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Unda, Jackson AU - Unda J AD - Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme (KWTRP), Kilifi, Kenya, Kenya. FAU - Munene, Fridah AU - Munene F AD - Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme (KWTRP), Kilifi, Kenya, Kenya. FAU - Kagwanja, Nancy AU - Kagwanja N AD - Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme (KWTRP), Kilifi, Kenya, Kenya. FAU - Jones, Caroline AU - Jones C AD - Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme (KWTRP), Kilifi, Kenya, Kenya. AD - Oxford University - Nuffield Department of Medicine (NDM), Oxford, UK. FAU - Mwangome, Martha AU - Mwangome M AUID- ORCID: 0000-0003-4806-1307 AD - Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme (KWTRP), Kilifi, Kenya, Kenya. AD - Oxford University - Nuffield Department of Medicine (NDM), Oxford, UK. AD - Kenya Medical Research Institute (KEMRI)- Centre for Geographic Medicine Research (CGMRC), Kilifi, Kenya. LA - eng GR - 221997/Z/20/Z/WT_/Wellcome Trust/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - *Breast Feeding MH - Female MH - Infant MH - Pilot Projects MH - Feasibility Studies MH - *Mothers MH - Adult MH - Kenya MH - Infant, Newborn MH - Patient Discharge MH - Weight Gain MH - *Infant Nutrition Disorders/therapy MH - Surveys and Questionnaires MH - *Malnutrition/therapy MH - Social Support MH - Follow-Up Studies MH - Male PMC - PMC13176648 OTO - NOTNLM OT - Breastfeeding support OT - breastfeeding peer supporters OT - infant nutrition OT - infants under 6 months OT - malnutrition OT - wasting COIS- The authors declare no conflicts of interest. EDAT- 2026/05/15 06:30 MHDA- 2026/05/15 06:31 PMCR- 2026/05/14 CRDT- 2026/05/15 02:13 PHST- 2026/04/10 00:00 [revised] PHST- 2025/12/09 00:00 [received] PHST- 2026/04/14 00:00 [accepted] PHST- 2026/05/15 06:31 [medline] PHST- 2026/05/15 06:30 [pubmed] PHST- 2026/05/15 02:13 [entrez] PHST- 2026/05/14 00:00 [pmc-release] AID - MCN70202 [pii] AID - 10.1111/mcn.70202 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jul;22(3):e70202. doi: 10.1111/mcn.70202. PMID- 42136081 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1097-0258 (Electronic) IS - 0277-6715 (Print) IS - 0277-6715 (Linking) VI - 45 IP - 10-12 DP - 2026 May TI - Correcting Measurement Error and Zero Inflation in Functional Covariates for Scalar-on-Function Quantile Regression. PG - e70598 LID - 10.1002/sim.70598 [doi] AB - Wearable devices collect time-varying biobehavioral data, offering opportunities to investigate how behaviors influence health outcomes. However, these data often contain measurement error and excess zeros (due to nonwear, sedentary behavior, or connectivity issues), each characterized by subject-specific distributions. Current statistical methods fail to address these issues simultaneously. We introduce a novel modeling framework for zero-inflated and error-prone functional data by incorporating a subject-specific time-varying validity indicator that explicitly distinguishes structural zeros from intrinsic values. We iteratively estimate the latent functional covariates and zero-inflation probabilities via maximum likelihood, using basis expansions and linear mixed models to adjust for measurement error. To assess the effects of the recovered latent covariates, we apply joint quantile regression across multiple quantile levels. Through extensive simulations, we demonstrate that our approach significantly improves estimation accuracy over methods that only address measurement error, and joint estimation yields substantial improvements compared with fitting separate quantile regressions. Applied to a childhood obesity study, our approach effectively corrects for zero inflation and measurement error in step counts, yielding results that closely align with energy expenditure and supporting their use as a proxy for physical activity. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Qin, Caihong AU - Qin C AUID- ORCID: 0000-0002-9529-0500 AD - Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, Indiana, USA. FAU - Xue, Lan AU - Xue L AD - Department of Statistics, Oregon State University, Corvallis, Oregon, USA. FAU - Beyaztas, Ufuk AU - Beyaztas U AD - Department of Statistics, Marmara University, Istanbul, Turkey. FAU - Zoh, Roger S AU - Zoh RS AUID- ORCID: 0000-0002-8066-1153 AD - Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, Indiana, USA. FAU - Benden, Mark AU - Benden M AD - Department of Environmental and Occupational Health, School of Public Health, Texas A&M University, College Station, Texas, USA. FAU - Goldsmith, Jeff AU - Goldsmith J AD - Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, New York, USA. FAU - Tekwe, Carmen D AU - Tekwe CD AUID- ORCID: 0000-0002-1857-2416 AD - Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, Indiana, USA. LA - eng GR - R01 DK132385/DK/NIDDK NIH HHS/United States GR - R01 DK136994/DK/NIDDK NIH HHS/United States GR - 1R01DK136994-01A1/National Institutes of Diabetes, Digestive, and Kidney Diseases/ GR - R01DK132385/National Institutes of Diabetes, Digestive, and Kidney Diseases/ PT - Journal Article PL - England TA - Stat Med JT - Statistics in medicine JID - 8215016 SB - IM MH - Humans MH - Computer Simulation MH - Likelihood Functions MH - Pediatric Obesity MH - Regression Analysis MH - Exercise MH - *Models, Statistical MH - Wearable Electronic Devices MH - Linear Models MH - Child MH - Energy Metabolism PMC - PMC13215663 MID - NIHMS2177779 OTO - NOTNLM OT - childhood obesity OT - excess zeros OT - functional data OT - physical activity OT - wearable devices COIS- Conflicts of Interest The authors declare no conflicts of interest. EDAT- 2026/05/15 06:29 MHDA- 2026/05/15 06:30 PMCR- 2026/05/27 CRDT- 2026/05/15 02:12 PHST- 2025/11/24 00:00 [revised] PHST- 2025/06/11 00:00 [received] PHST- 2026/05/05 00:00 [accepted] PHST- 2026/05/15 06:30 [medline] PHST- 2026/05/15 06:29 [pubmed] PHST- 2026/05/15 02:12 [entrez] PHST- 2026/05/27 00:00 [pmc-release] AID - 10.1002/sim.70598 [doi] PST - ppublish SO - Stat Med. 2026 May;45(10-12):e70598. doi: 10.1002/sim.70598. PMID- 42136020 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260921 IS - 1550-2783 (Electronic) IS - 1550-2783 (Linking) VI - 23 IP - 1 DP - 2026 Dec 31 TI - Dietary intake, nutrition knowledge, and behavior in youth team sport athletes: a scoping review and call to advance research and practice. PG - 2671431 LID - 10.1080/15502783.2026.2671431 [doi] LID - 2671431 AB - BACKGROUND: Youth team sport athletes face unique nutritional challenges due to the combined demands of growth, development and exercise. This scoping review systematically mapped the literature on dietary intake, nutrition knowledge, education interventions and factors influencing dietary behaviors in male and female team sport athletes aged 12-19 years. The review aimed to identify knowledge gaps, highlight methodological limitations and inform recommendations for advancing both research and practice in this population. METHODS: The review followed PRISMA-ScR guidelines and was pre-registered on the Open Science Framework. Eligible studies examined dietary intake, nutrition knowledge, education interventions and factors influencing dietary behavior in youth team sport athletes. Searches were conducted across PubMed, MEDLINE, PsycINFO, SPORTDiscus and gray literature sources. Study selection and data charting were conducted by the lead reviewer, with independent verification by a second reviewer. Findings were synthesized using descriptive analysis and thematic synthesis across these four domains. RESULTS: Fifty-seven studies involving 4,369 youth team sport athletes were included. Cross-sectional designs predominated (59.6%) and the evidence base was characterized by significant methodological inconsistencies, including wide variation in dietary assessment methods, limited adjustment for misreporting and substantial underrepresentation of female athletes who accounted for 26.9% of the total sample. Energy and carbohydrate intake were frequently reported below recommended levels, most evident during periods of intensive training and competition. However, findings from studies using doubly labeled water suggest that the magnitude of reported deficits may be overestimated due to dietary underreporting and imprecise estimation of energy expenditure. Protein and fat intake generally met recommendations although micronutrient intake often fell short, particularly for vitamins A, D, and E, calcium and iron. Nutrition knowledge was limited, particularly for sport-specific topics and none of the questionnaires used were validated for adolescent populations. Twelve education interventions were identified; education-only approaches rarely produced changes in dietary behavior, whereas interventions incorporating behavior change components tended to report improvements. Only five studies examined factors influencing dietary behavior, finding that parents, coaches and peers acted as both enablers and barriers to dietary adherence, and that environmental constraints compromised dietary quality. CONCLUSIONS: Youth team sport athletes commonly exhibit inadequate reported energy and carbohydrate intake alongside frequent micronutrient shortfalls, although the reliability of these estimates is limited by methodological constraints. Nutrition knowledge is generally poor, particularly in sport-specific areas. Dietary behaviors are shaped by individual, social and environmental influences that extend beyond knowledge alone and education interventions rarely produce sustained dietary change without the integration of behavior change strategies. Future research should prioritize more rigorous and consistent methodological approaches, improved representation of female athletes and the development of youth-specific validated assessment tools. Given the scope and persistence of the methodological inconsistencies identified, the development of an expert-led consensus statement on standards for dietary assessment, nutrition knowledge measurement, intervention design and participant characterization may help advance the quality and comparability of future research in this population. FAU - Irwin, Neil AU - Irwin N AUID- ORCID: 0000-0002-4465-7376 AD - Department of Sport and Health Science, Technological University of the Shannon, Athlone, Ireland. AD - SHE Research Group, Technological University of the Shannon, Athlone, Ireland. FAU - O Cathain, Ciaran AU - O Cathain C AUID- ORCID: 0000-0002-8526-8924 AD - Department of Sport and Health Science, Technological University of the Shannon, Athlone, Ireland. AD - SHE Research Group, Technological University of the Shannon, Athlone, Ireland. AD - Department of Sport Science and Nutrition, Maynooth University, Maynooth, Ireland. FAU - Ward, Cormac AU - Ward C AUID- ORCID: 0000-0001-7343-2179 AD - Department of Sport and Health Science, Technological University of the Shannon, Athlone, Ireland. FAU - Kelly, David AU - Kelly D AUID- ORCID: 0000-0002-6131-4834 AD - Department of Sport and Health Science, Technological University of the Shannon, Athlone, Ireland. AD - SHE Research Group, Technological University of the Shannon, Athlone, Ireland. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260514 PL - United States TA - J Int Soc Sports Nutr JT - Journal of the International Society of Sports Nutrition JID - 101234168 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Young Adult MH - *Athletes MH - *Diet MH - Energy Intake MH - Evidence Gaps MH - *Feeding Behavior MH - *Health Knowledge, Attitudes, Practice MH - Sports Nutritional Physiological Phenomena MH - *Youth Sports PMC - PMC13182181 OTO - NOTNLM OT - adolescent OT - dietary intake OT - nutrition knowledge OT - scoping review OT - team sports OT - youth athletes COIS- The authors report there are no competing interests to declare. EDAT- 2026/05/15 06:29 MHDA- 2026/05/15 06:30 PMCR- 2026/05/14 CRDT- 2026/05/15 01:33 PHST- 2026/05/15 06:30 [medline] PHST- 2026/05/15 06:29 [pubmed] PHST- 2026/05/15 01:33 [entrez] PHST- 2026/05/14 00:00 [pmc-release] AID - 2671431 [pii] AID - 10.1080/15502783.2026.2671431 [doi] PST - ppublish SO - J Int Soc Sports Nutr. 2026 Dec 31;23(1):2671431. doi: 10.1080/15502783.2026.2671431. Epub 2026 May 14. PMID- 42135987 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1550-2783 (Electronic) IS - 1550-2783 (Linking) VI - 23 IP - 1 DP - 2026 Dec 31 TI - The development and validation of a football-specific nutrition knowledge questionnaire for use within adolescent footballers. PG - 2671429 LID - 10.1080/15502783.2026.2671429 [doi] LID - 2671429 AB - BACKGROUND: Elite adolescent footballers experience periods of rapid growth and maturation alongside their intense training programs. Therefore, their nutritional habits should reflect this and be tailored to support healthy growth and recovery [1]. Research has shown that U12/13 and U15 footballers within Category One Academy require approximately 2859 +/- 265 kcal.d (range 2275-3903 kcal.d) and 3029 +/- 262 kcal.d (range 2738-3726 kcal.d), respectively, to fuel their training programs [2]. Food choices can be influenced by a range of physiological, psychological, and social factors, with nutrition knowledge being recognized as an important determinant of nutritional adherence among elite adolescent footballers. However, an ongoing limitation regarding assessing nutrition knowledge is the availability of high-quality, valid procedures, as well as a lack of specificity for certain sports and cohorts. Therefore, the aim of this study was to develop and validate a nutrition knowledge tool, which is based on the most recent football/youth nutrition guidelines, for use with English football academies. METHODS: Recruitment of participants involved three different cohorts: (1) an expert panel for the initial item development of the questionnaire via modifying a previously validated tool, the A-NSKQ, (2) an adolescent football player cohort in which much of the analysis would be conducted, and (3) a university student cohort to provide a construct validity comparison. A robust methodology was followed, incorporating content and face validity and item analysis with techniques from classical test theory (CTT). Content validity involved recruiting experts from the industry (nutrition/sport science/academia) to review the initial items and provide objective feedback via a content validity index (CVI) score. Once this was complete, a sample of the adolescent cohort the tool was intended for was recruited to complete the questionnaire and provide live feedback on readability (face validity). Finally, both the full adolescent cohorts completed the questionnaire (n = 66), alongside a cohort of university-educated students (n = 109), to prove the construct validity of the tool. RESULTS: The resulting tool has 32 items, split across two subsections: general nutrition knowledge (GNK) and sport nutrition knowledge (SNK), and takes around eight minutes to complete. Content and face validity were confirmed by field experts and a sample of participants from whom the tool was intended, respectively. Modifications to the items were made due to the findings of the difficulty index, distractor utility and discrimination index. Evidence of construct validity was examined for the tool by comparing the results from nutrition-educated participants (63 +/- 10%) vs non-nutrition-educated participants (52 +/- 11%) (p = < 0.001). The test-retest reliability of the tool was confirmed, with a strong correlation (r = 0.77, p = < 0.001) between the individual scores of the adolescent footballers on the two attempts of the test, approximately three weeks apart. CONCLUSION: The final version of the tool presents a valid and reliable tool, specific to the sport of football, that practitioners can use to measure the effectiveness of nutrition curriculums within English football academies. FAU - Morgan, Dean K AU - Morgan DK AUID- ORCID: 0000-0002-9368-4960 AD - School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom. AD - Department of Sport Science and Medical, West Bromwich Albion Football Club, West Bromwich, United Kingdom. FAU - Trakman, Gina L AU - Trakman GL AUID- ORCID: 0000-0002-2483-0899 AD - Department of Sports, Exercise and Nutrition Sciences, La Trobe University, Melbourne, Australia. FAU - Boardley, Ian D AU - Boardley ID AUID- ORCID: 0000-0001-5651-7816 AD - School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom. FAU - Page, Tom AU - Page T AD - Department of Sport Science and Medical, West Bromwich Albion Football Club, West Bromwich, United Kingdom. FAU - Drust, Barry AU - Drust B AUID- ORCID: 0000-0003-2092-6962 AD - School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom. FAU - Brownlee, Thomas AU - Brownlee T AD - School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, United Kingdom. LA - eng PT - Journal Article PT - Validation Study DEP - 20260514 PL - United States TA - J Int Soc Sports Nutr JT - Journal of the International Society of Sports Nutrition JID - 101234168 SB - IM MH - Humans MH - Adolescent MH - Surveys and Questionnaires/standards MH - *Health Knowledge, Attitudes, Practice MH - *Soccer MH - *Sports Nutritional Physiological Phenomena MH - Male MH - Reproducibility of Results MH - Sports Nutritional Sciences PMC - PMC13182167 OTO - NOTNLM OT - Nutrition knowledge OT - adolescent athletes OT - classical test theory OT - football OT - questionnaire OT - sports nutrition COIS- No potential conflict of interest was reported by the author(s). EDAT- 2026/05/15 06:30 MHDA- 2026/05/15 06:31 PMCR- 2026/05/14 CRDT- 2026/05/15 01:24 PHST- 2026/05/15 06:31 [medline] PHST- 2026/05/15 06:30 [pubmed] PHST- 2026/05/15 01:24 [entrez] PHST- 2026/05/14 00:00 [pmc-release] AID - 2671429 [pii] AID - 10.1080/15502783.2026.2671429 [doi] PST - ppublish SO - J Int Soc Sports Nutr. 2026 Dec 31;23(1):2671429. doi: 10.1080/15502783.2026.2671429. Epub 2026 May 14. PMID- 42135841 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 23 IP - 1 DP - 2026 May 14 TI - Physical activity and mood in daily life - a multi-burst ambulatory assessment study disentangling state and trait components of within-person associations. LID - 10.1186/s12966-026-01932-x [doi] LID - 70 AB - BACKGROUND: Physical activity (PA) and mood are associated in daily life. Prior studies showed that these associations are moderated by contextual factors (e.g., weather conditions) and differ between individuals. Yet, it remains unclear to what extent associations between PA and mood reflect stable, person-specific characteristics or fluctuate over time. METHODS: We examined the temporal stability of within-person PA-mood associations derived from three one-week ambulatory assessments across three consecutive years in 65 adolescents and young adults. Mood was assessed via e-diaries, and PA was recorded with accelerometers. Multilevel models estimated the effects of preceding PA on mood. Between-person differences and within-person stability were quantified by random-effect variances and correlations across participants and weeks. RESULTS: As hypothesized, PA was positively associated with subsequent energetic arousal (beta = 4.88, p < .001) and valence (beta = 1.27, p = .042) but negatively with calmness (beta = -1.86, p = .003). Intraclass Correlation Coefficients indicate that 64%, 44%, and 80% of variance of the weekly PA-mood associations of individuals are attributable to between-person differences, while 36%, 56%, and 20% of variance are accounted for by within-person fluctuations in associations of PA with energetic arousal, valence, and calmness, respectively. CONCLUSIONS: For the first time, we show that PA-mood associations reflect a combination of both stable 'trait' components (between subjects) and 'state' variability (within subjects). Both have important implications for personalized and context-sensitive intervention approaches, such as just-in-time adaptive interventions. Future research is needed to unravel which situational components and person characteristics shape the variability of associations. CI - (c) 2026. The Author(s). FAU - Olfermann, Robin AU - Olfermann R AD - Department of Sport and Exercise Science, Research Group Sport and Exercise Psychology, Paris Lodron University Salzburg, Salzburg, Austria. robin.olfermann@kit.edu. AD - Faculty of Sport Science, Junior Research Group eHealth and sports analytics, Ruhr University Bochum, Bochum, Germany. robin.olfermann@kit.edu. AD - Department of Sports and Sports Science, Mental mHealth Lab, Karlsruhe Institute of Technology, Karlsruhe, Germany. robin.olfermann@kit.edu. FAU - Reinhard, Iris AU - Reinhard I AD - Department of Biostatistics, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany. FAU - Benedyk, Anastasia AU - Benedyk A AD - Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany. FAU - Berhe, Oksana AU - Berhe O AD - Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany. FAU - Rehder, Johanna AU - Rehder J AD - Department of Sport and Exercise Science, Research Group Sport and Exercise Psychology, Paris Lodron University Salzburg, Salzburg, Austria. AD - Faculty of Sport Science, Junior Research Group eHealth and sports analytics, Ruhr University Bochum, Bochum, Germany. FAU - Giurgiu, Marco AU - Giurgiu M AD - Institute of Movement Therapy and movement-oriented Prevention and Rehabilitation, German Sport University Cologne, Cologne, Germany. FAU - Braun, Urs AU - Braun U AD - Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany. FAU - Ebner-Priemer, Ulrich AU - Ebner-Priemer U AD - Department of Sports and Sports Science, Mental mHealth Lab, Karlsruhe Institute of Technology, Karlsruhe, Germany. AD - Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany. FAU - Tost, Heike AU - Tost H AD - Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany. FAU - Meyer-Lindenberg, Andreas AU - Meyer-Lindenberg A AD - Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany. FAU - Reichert, Markus AU - Reichert M AD - Department of Sport and Exercise Science, Research Group Sport and Exercise Psychology, Paris Lodron University Salzburg, Salzburg, Austria. AD - Faculty of Sport Science, Junior Research Group eHealth and sports analytics, Ruhr University Bochum, Bochum, Germany. AD - Department of Sports and Sports Science, Mental mHealth Lab, Karlsruhe Institute of Technology, Karlsruhe, Germany. AD - Department of Psychiatry and Psychotherapy, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Mannheim, Germany. LA - eng PT - Journal Article DEP - 20260514 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - *Affect/physiology MH - Female MH - *Exercise/psychology MH - Adolescent MH - Accelerometry MH - Male MH - Young Adult MH - Adult PMC - PMC13343692 OTO - NOTNLM OT - Accelerometry OT - Affective well-being OT - Ambulatory assessment OT - Ecological momentary assessment OT - Non-exercise activity OT - States OT - Traits OT - Wearables COIS- Declarations. Ethics approval and consent to participate: All participants provided written informed consent for a study protocol approved by the institutional review board of Heidelberg University. The Medical Ethics Committee II of the Medical Faculty Mannheim at the Ruprecht-Karls-University in Heidelberg, Germany, approved the study (approval no. 2014-555 N-MA). Consent for publication: Not applicable. Competing interests: A.M.-L. has received consultant fees from the American Association for the Advancement of Science, Atheneum Partners, Blueprint Partnership, Boehringer Ingelheim, Daimler und Benz Stiftung, Elsevier, F. Hoffmann-La Roche, ICARE Schizophrenia, K. G. Jebsen Foundation, L.E.K. Consulting, Lundbeck International Foundation (LINF), R. Adamczak, Roche Pharma, Science Foundation, Sumitomo Dainippon Pharma, Synapsis Foundation - Alzheimer Research Switzerland, System Analytics, and has received lecture fees, including travel fees, from Boehringer Ingelheim, Fama Public Relations, Institut d'investigacions Biomediques August Pi i Sunyer (IDIBAPS), Janssen-Cilag, Klinikum Christophsbad, Goppingen, Lilly Deutschland, Luzerner Psychiatrie, LVR Klinikum Dusseldorf, LWL PsychiatrieVerbund Westfalen-Lippe, Otsuka Pharmaceuticals, Reunions i Ciencia S. L., the Spanish Society of Psychiatry, Sudwestrundfunk Fernsehen, Stern TV and Vitos Klinikum Kurhessen. U.E.-P. receives fees for consulting from Boehringer-Ingelheim and speaker honorarium from Angelini Pharma, which are not related to the submitted work.All other authors have no competing interests. EDAT- 2026/05/15 06:29 MHDA- 2026/07/09 08:36 PMCR- 2026/05/14 CRDT- 2026/05/15 00:02 PHST- 2025/12/09 00:00 [received] PHST- 2026/05/05 00:00 [accepted] PHST- 2026/07/09 08:36 [medline] PHST- 2026/05/15 06:29 [pubmed] PHST- 2026/05/15 00:02 [entrez] PHST- 2026/05/14 00:00 [pmc-release] AID - 10.1186/s12966-026-01932-x [pii] AID - 1932 [pii] AID - 10.1186/s12966-026-01932-x [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2026 May 14;23(1):70. doi: 10.1186/s12966-026-01932-x. PMID- 42135754 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 May 14 TI - Voices on a multicomponent school-based physical activity intervention: a qualitative study with school leaders, teachers, and students from the MOVESCHOOL study. LID - 10.1186/s12889-026-27718-1 [doi] LID - 2069 AB - BACKGROUND: Adolescent physical inactivity is a global public health priority, and schools are identified as a critical setting for health promotion. While multicomponent "whole-school" interventions are recommended, there is a lack of qualitative evidence regarding their implementation and the experiences of key agents, particularly in secondary education settings. This research explored the perceptions and experiences of school leaders, teachers, and students regarding the MOVESCHOOL study. METHODS: A qualitative study was conducted as part of the MOVESCHOOL study, a 29-week multicomponent intervention that integrated physically active learning, active break, and active recess in secondary education. A total of five school leaders, 20 teachers, and 141 students participated through semi-structured interviews and focus groups. Data were analysed using a hybrid qualitative content analysis, combining deductive and inductive coding. RESULTS: The findings indicated that the intervention, in addition to increasing students' physical activity levels, contributed positively to their social interactions, motivation towards school, attention capacity, and enjoyment during the school day, which in turn influenced their academic performance. Furthermore, four key pillars for the feasibility and sustainability of the intervention were identified: the commitment and engagement to the intervention of school leaders and teachers, sustained student involvement determined by enjoyment, the availability of resources, and the presence of an intervention specialist as a catalytic factor. CONCLUSIONS: The intervention provided both social and academic benefits, alongside increased physical activity, although its long-term feasibility and sustainability will depend on how this approach can be adapted to the contextual and structural conditions of each school, going beyond the intervention design itself. TRIAL REGISTRATION: ClinicalTrials.gov, identifier NCT06254638. Registered on 12 February 2024. CI - (c) 2026. The Author(s). FAU - Bandera-Campos, Francisco J AU - Bandera-Campos FJ AD - GALENO Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Puerto Real, Spain. AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. FAU - Sanchez-Oliva, David AU - Sanchez-Oliva D AD - GALENO Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Puerto Real, Spain. davidsanchez@unex.es. AD - ACAFYDE Research Group, Department of Didactics of Musical, Plastic and Body Expression, Faculty of Sports Sciences, University of Extremadura, Av. de la Universidad, s/n, Caceres, 10071, Spain. davidsanchez@unex.es. AD - University Institute for Research and Innovation in Sport, University of Extremadura, Caceres, Spain. davidsanchez@unex.es. FAU - Gonzalez-Perez, Maria AU - Gonzalez-Perez M AD - GALENO Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Puerto Real, Spain. AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. FAU - Martin-Acosta, Fatima AU - Martin-Acosta F AD - GALENO Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Puerto Real, Spain. AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. FAU - Camiletti-Moiron, Daniel AU - Camiletti-Moiron D AD - GALENO Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Puerto Real, Spain. AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. FAU - Grao-Cruces, Alberto AU - Grao-Cruces A AD - GALENO Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Puerto Real, Spain. AD - Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. LA - eng SI - ClinicalTrials.gov/NCT06254638 GR - FPU21/03385/Ministerio de Ciencia, Innovacion y Universidades/ GR - CNS2022-135604/Ministerio de Ciencia, Innovacion y Universidades/ GR - FPU22/01430/Ministerio de Ciencia, Innovacion y Universidades/ GR - PID2022-137450OA-I00/Ministerio de Ciencia, Innovacion y Universidades/ GR - PU/EPIF-FPI-CT/CP/2023-046/Universidad de Cadiz/ PT - Clinical Study PT - Journal Article DEP - 20260514 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - *Exercise/psychology MH - Focus Groups MH - *Health Promotion/organization & administration/methods MH - Interviews as Topic MH - *Leadership MH - Qualitative Research MH - *School Health Services/organization & administration MH - *School Teachers/psychology/statistics & numerical data MH - *Schools MH - *Students/psychology/statistics & numerical data PMC - PMC13340252 OTO - NOTNLM OT - Active break OT - Active recess OT - Adolescents OT - Feasibility OT - Physically active learning OT - School-level physical activity intervention OT - Sustainability COIS- Declarations. Ethics approval and consent to participate: Ethical approval for this study was obtained from the Bioethics Committees of the University of Cadiz (Cadiz, Spain; approval n masculine CEENB006-2023), and the Bioethics and Biosafety Committess of the University of Extremadura (Caceres, Spain; n masculine 174/2023). It was also conducted in accordance with the local legislation and institutional requirements. Written informed consent was obtained from the participants and the minors' legal guardians for their participation in this study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/15 00:31 MHDA- 2026/07/08 20:01 PMCR- 2026/05/14 CRDT- 2026/05/14 23:58 PHST- 2026/02/09 00:00 [received] PHST- 2026/05/06 00:00 [accepted] PHST- 2026/07/08 20:01 [medline] PHST- 2026/05/15 00:31 [pubmed] PHST- 2026/05/14 23:58 [entrez] PHST- 2026/05/14 00:00 [pmc-release] AID - 10.1186/s12889-026-27718-1 [pii] AID - 27718 [pii] AID - 10.1186/s12889-026-27718-1 [doi] PST - epublish SO - BMC Public Health. 2026 May 14;26(1):2069. doi: 10.1186/s12889-026-27718-1. PMID- 42135646 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 May 14 TI - Behavioral and parental predictors of infant and toddler sleep quality. LID - 10.1186/s12887-026-06713-w [doi] LID - 631 AB - BACKGROUND: Sleep is critical for early development, yet sleep disturbances are prevalent. In low- and middle-income countries (LMICs) like Iran, cultural practices can significantly shape sleep behaviors. This study aimed to identify behavioral and parental factors associated with sleep quality among infants and toddlers aged 0-36 months in Iran. METHODS: This cross-sectional study surveyed 358 parents using the validated Persian version of the Brief Infant Sleep Questionnaire-Revised (BISQ-R). Multiple linear regression was conducted to examine associations between behavioral and parental factors and the BISQ-R Total Sleep Score. RESULTS: The mean Total Sleep Score was 64.2 (SD = 14.3), indicating moderate overall sleep quality. The final regression model explained 28% of the variance in sleep scores (Adjusted R(2) =0.28, p<.001). Pre-sleep screen time, bed-sharing, and increasing child age were significantly negatively associated with sleep quality, whereas higher birth weight and greater parental education were positively associated. CONCLUSION: Modifiable behaviors, particularly screen use before bedtime and bed-sharing, were significantly associated with poorer parent-reported sleep quality in this cultural context. These findings highlight the need for culturally sensitive parental education and anticipatory guidance to support healthy sleep hygiene. CI - (c) 2026. The Author(s). FAU - Alavi, Mousa AU - Alavi M AUID- ORCID: 0000-0003-4847-2915 AD - Nursing and Midwifery Care Research Center, Isfahan university of Medical Sciences, Isfahan, Iran. FAU - Kalhor, Faramarz AU - Kalhor F AUID- ORCID: 0000-0002-9436-0546 AD - Nursing and Midwifery Care Research Center, Isfahan university of Medical Sciences, Isfahan, Iran. faramaraz@nm.mui.ac.ir. AD - Trauma Nursing Research Center, Kashan university of medical sciences, Kashan, Iran. faramaraz@nm.mui.ac.ir. FAU - Khaksar, Sajjad AU - Khaksar S AUID- ORCID: 0000-0002-7374-5877 AD - Critical care Department, Shariati Hospital, Social Security Organization, Isfahan, Iran. FAU - Ghanavatpour, Afarin AU - Ghanavatpour A AUID- ORCID: 0000-0002-3932-0736 AD - Department of Nursing and Midwifery, Isf. C., Islamic Azad University, Isfahan, Iran. LA - eng PT - Journal Article DEP - 20260514 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Sleep Quality MH - Infant MH - *Parents/psychology MH - Male MH - Female MH - Child, Preschool MH - Iran MH - Infant, Newborn MH - Surveys and Questionnaires MH - Screen Time MH - *Sleep MH - Linear Models PMC - PMC13344015 OTO - NOTNLM OT - Bed-sharing OT - Brief Infant Sleep Questionnaire (BISQ-R) OT - Infant sleep OT - Parent OT - Screen exposure OT - Sleep hygiene OT - Toddler COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Research Ethics Committee of the Schools of Nursing, Rehabilitation, and Management at Isfahan University of Medical Sciences (Approval ID: IR.MUI.NUREMA.REC.1401.031; Scientific Code: 2400282; Approval Date: 2024-05-07). Ethical principles were observed throughout the study in accordance with the Declaration of Helsinki. Informed consent was obtained from all participating parents or legal guardians prior to data collection. Participant confidentiality and data anonymity were strictly maintained. Consent for publication: Written informed consent for the publication of anonymized data was obtained from the parents or legal guardians of all participants. Competing interests: The authors declare no competing interests. EDAT- 2026/05/15 00:31 MHDA- 2026/07/09 08:36 PMCR- 2026/05/14 CRDT- 2026/05/14 23:54 PHST- 2025/08/05 00:00 [received] PHST- 2026/03/04 00:00 [accepted] PHST- 2026/07/09 08:36 [medline] PHST- 2026/05/15 00:31 [pubmed] PHST- 2026/05/14 23:54 [entrez] PHST- 2026/05/14 00:00 [pmc-release] AID - 10.1186/s12887-026-06713-w [pii] AID - 6713 [pii] AID - 10.1186/s12887-026-06713-w [doi] PST - epublish SO - BMC Pediatr. 2026 May 14;26(1):631. doi: 10.1186/s12887-026-06713-w. PMID- 42135615 OWN - NLM STAT- MEDLINE DCOM- 20260912 LR - 20260914 IS - 1531-4995 (Electronic) IS - 0023-852X (Print) IS - 0023-852X (Linking) VI - 136 IP - 10 DP - 2026 Oct TI - Identifying High-Risk Children Safe for Same-Day Discharge After Tonsillectomy. PG - 4497-4504 LID - 10.1002/lary.70629 [doi] AB - OBJECTIVE: Current guidelines recommend overnight admission for children with severe obstructive sleep apnea (OSA) and obesity undergoing tonsillectomy, although most have uneventful postoperative courses. We aimed to identify low-risk subgroups within this high-risk population who may be candidates for same-day discharge. METHODS: Retrospective cohort study of children aged 2-18 years with obesity (>/= 95th BMI percentile) and severe OSA (AHI >/= 10 events/h and/or SpO(2) nadir < 80%) undergoing tonsillectomy at a tertiary children's hospital (2021-2024). The primary outcome was a severe perioperative event: ICU admission, prolonged hospitalization (> 48 h), or need for advanced respiratory support. Bayesian logistic regression using informative priors identified predictors. Model-based risk stratification and simplified clinical rules were evaluated using sensitivity, specificity, and negative predictive value. RESULTS: Among 304 children, 36 (11.8%) experienced a severe event. SpO(2) nadir was the strongest predictor (beta = -0.668, 95% CrI [-1.164, -0.172], directional probability 99.6%), followed by Class III obesity (97.0%) and AHI (95.0%). Model-derived stratification identified 33% of patients with < 5% predicted probability of severe events. A clinical rule combining AHI < 25 events/h and SpO(2) nadir > 85% showed sensitivity 85.7% and negative predictive value 99.5%, corresponding to an observed event rate < 5%. CONCLUSION: Most obese children with severe OSA do not experience severe perioperative events. Simple polysomnographic criteria can identify very low-risk patients who may be candidates for same-day discharge planning. These findings support a more individualized approach to postoperative admission; prospective validation is needed before implementation. CI - (c) 2026 The Author(s). The Laryngoscope published by Wiley Periodicals LLC on behalf of The American Laryngological, Rhinological and Otological Society, Inc. FAU - Ho, Amy AU - Ho A AD - Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA. FAU - Kou, Yann-Fuu AU - Kou YF AUID- ORCID: 0000-0001-6801-7544 AD - Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA. AD - Division of Pediatric Otolaryngology, Children's Health Dallas, Dallas, Texas, USA. FAU - Liu, Christopher AU - Liu C AUID- ORCID: 0000-0001-7871-4060 AD - Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA. AD - Division of Pediatric Otolaryngology, Children's Health Dallas, Dallas, Texas, USA. FAU - Wang, Cynthia S AU - Wang CS AD - Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA. AD - Division of Pediatric Otolaryngology, Children's Health Dallas, Dallas, Texas, USA. FAU - Lenes-Voit, Felicity AU - Lenes-Voit F AD - Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA. AD - Division of Pediatric Otolaryngology, Children's Health Dallas, Dallas, Texas, USA. FAU - Chorney, Stephen R AU - Chorney SR AUID- ORCID: 0000-0003-1419-6019 AD - Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA. AD - Division of Pediatric Otolaryngology, Children's Health Dallas, Dallas, Texas, USA. FAU - Lee, Kenneth AU - Lee K AUID- ORCID: 0000-0001-6148-1133 AD - Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA. AD - Division of Pediatric Otolaryngology, Children's Health Dallas, Dallas, Texas, USA. FAU - Ulualp, Seckin AU - Ulualp S AUID- ORCID: 0000-0002-0503-7051 AD - Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA. AD - Division of Pediatric Otolaryngology, Children's Health Dallas, Dallas, Texas, USA. FAU - Mitchell, Ron B AU - Mitchell RB AUID- ORCID: 0000-0001-7890-0541 AD - Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA. AD - Division of Pediatric Otolaryngology, Children's Health Dallas, Dallas, Texas, USA. FAU - Johnson, Romaine F AU - Johnson RF AUID- ORCID: 0000-0002-2322-5347 AD - Department of Otolaryngology-Head and Neck Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA. AD - Division of Pediatric Otolaryngology, Children's Health Dallas, Dallas, Texas, USA. LA - eng PT - Journal Article DEP - 20260514 PL - United States TA - Laryngoscope JT - The Laryngoscope JID - 8607378 SB - IM MH - Humans MH - *Tonsillectomy/adverse effects MH - Retrospective Studies MH - Child MH - Female MH - *Sleep Apnea, Obstructive/surgery/complications MH - Child, Preschool MH - *Patient Discharge/statistics & numerical data MH - Male MH - Adolescent MH - *Postoperative Complications/epidemiology/etiology MH - Risk Assessment/methods MH - Polysomnography MH - *Pediatric Obesity/complications PMC - PMC13569659 OTO - NOTNLM OT - Bayesian analysis OT - T&A outcomes OT - obstructive sleep apnea OT - pediatric obesity OT - polysomnography OT - postoperative complications OT - risk assessment COIS- Presented as a poster at the Triological Society Combined Sections Meeting, Orlando, Florida, January 20-23, 2025. Stephen R. Chorney is an education consultant for Smith and Nephew. Kenneth Lee is the Chief Medical Officer of Qualio Oto. The other authors declare no conflicts of interest. EDAT- 2026/05/15 00:31 MHDA- 2026/09/13 00:50 PMCR- 2026/09/12 CRDT- 2026/05/14 23:43 PHST- 2026/04/03 00:00 [revised] PHST- 2026/02/01 00:00 [received] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/09/13 00:50 [medline] PHST- 2026/05/15 00:31 [pubmed] PHST- 2026/05/14 23:43 [entrez] PHST- 2026/09/12 00:00 [pmc-release] AID - LARY70629 [pii] AID - 10.1002/lary.70629 [doi] PST - ppublish SO - Laryngoscope. 2026 Oct;136(10):4497-4504. doi: 10.1002/lary.70629. Epub 2026 May 14. PMID- 42134963 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20261007 IS - 1478-5242 (Electronic) IS - 0960-1643 (Linking) VI - 76 IP - suppl 1 DP - 2026 May TI - Implementation of a therapeutic education programme for paediatric feeding disorders in primary care: a first experience in Hauts-de-France. LID - bjgp26X745569 [pii] LID - 10.3399/bjgp26X745569 [doi] AB - BACKGROUND: Paediatric feeding disorders (PFDs) are common but often underrecognised in primary care. Families frequently face long diagnostic delays and fragmented management. Therapeutic patient education (TPE) programmes exist in hospital settings but remain rare in community care. AIM: To design and implement a structured, multidisciplinary TPE programme for children with PFD and their parents, adapted to a primary care context. METHOD: The pilot programme was launched in February 2025 within the Maison de Sante Pluriprofessionnelle Universitaire Corneille (MSPU; Hauts-de-France). It was developed by a primary care team in partnership with the regional CPTS (Communaute Professionnelle Territoriale de Sante), which will provide ongoing financial support to extend the initiative. This programme consists of five 2-hour workshops involving one child (aged 3-8 years) and at least one parent per session. Each group includes six children and 14 parents, supervised by three health professionals - always including a speech therapist - trained in TPE and non-violent communication. Sessions cover eating mechanisms, posture, nutrition, sensory exploration, and emotional regulation. RESULTS: The first cycle involved six children and their families. Early feedback indicates high engagement, improved parental confidence, and observed progress in children's mealtime comfort. Twenty-four additional families are already registered and awaiting the next series of workshops planned for late 2025. CONCLUSION: This first TPE programme for PFD implemented in primary care demonstrates feasibility, strong acceptability, and interprofessional collaboration. It offers a promising model for community-based management of complex paediatric feeding issues. CI - (c) British Journal of General Practice 2026. FAU - Chardonnet, Isabelle AU - Chardonnet I AD - MSPU Corneille, Wattrelos, France and CPTS des 7 villes, Wattrelos, France isabellechardonnet4@gmail.com. FAU - Calafiore, Matthieu AU - Calafiore M AD - University of Lille, Lille, France; MSPU Corneille, Wattrelos, France; and CPTS des 7 villes, Wattrelos, France. FAU - Baran, Jan AU - Baran J AD - University of Lille, Lille, France; MSPU Corneille, Wattrelos, France; and CPTS des 7 villes, Wattrelos, France. LA - eng PT - Journal Article DEP - 20260514 PL - England TA - Br J Gen Pract JT - The British journal of general practice : the journal of the Royal College of General Practitioners JID - 9005323 SB - IM MH - Humans MH - Child MH - France MH - Child, Preschool MH - *Primary Health Care/organization & administration MH - *Patient Education as Topic/methods/organization & administration MH - *Feeding and Eating Disorders of Childhood/therapy MH - Female MH - Pilot Projects MH - *Parents/education MH - Male MH - Program Evaluation EDAT- 2026/05/15 00:31 MHDA- 2026/05/15 00:32 CRDT- 2026/05/14 21:03 PHST- 2026/05/15 00:32 [medline] PHST- 2026/05/15 00:31 [pubmed] PHST- 2026/05/14 21:03 [entrez] AID - 76/suppl_1/bjgp26X745569 [pii] AID - 10.3399/bjgp26X745569 [doi] PST - epublish SO - Br J Gen Pract. 2026 May 14;76(suppl 1):bjgp26X745569. doi: 10.3399/bjgp26X745569. Print 2026 May. PMID- 42133935 OWN - NLM STAT- MEDLINE DCOM- 20260515 LR - 20260910 IS - 2291-5222 (Electronic) IS - 2291-5222 (Linking) VI - 14 DP - 2026 May 14 TI - Smartphone Apps for Cannabis Cessation: Quality Assessment and Content Analysis. PG - e58908 LID - 10.2196/58908 [doi] LID - e58908 AB - BACKGROUND: Over the past 2 decades, global rates of cannabis use have risen significantly, especially among young adults. This has corresponded to an increase in cannabis-related problems and hospitalizations. Thus, there has been significant interest in developing new interventions that can help facilitate cannabis cessation and reduce hospitalization rates. Specifically, mobile apps have emerged as scalable and accessible stand-alone or adjunct interventions that can help individuals with cannabis use disorders. OBJECTIVE: This study aimed to evaluate the quality of free cannabis cessation apps available on both the Apple App Store and Google Play Store, focusing on the analysis of their features, content, and adherence to evidence-based practices. METHODS: A systematic search was conducted in April 2023 using a variety of keywords. The apps were deemed eligible if they were free, available in English, accessible on both the Apple App Store and the Google Play Store, and related to cannabis cessation. Eligible apps were used for at least 1 month and were rated on the Mobile App Rating Scale by 2 reviewers. Interrater reliability was excellent, with a weighted Cohen kappa of 0.893 (95% CI 0.835-0.943). RESULTS: Four apps were included in the analysis, namely, "Grounded-Quit Weed," "Quit Weed," "Marijuana Addiction Calendar," and "Marijuana Anonymous." The mean overall quality score of the apps was 3.4 out of 5, indicating poor to acceptable quality. The apps scored the highest on the "functionality" section and the lowest on the "information" section. Of the 4 apps, 3 focused on tracking cannabis use and duration of abstinence, whereas 1 focused on peer support. A limited number of cannabis cessation apps were identified, and those that were available were of low quality due to a lack of evidence-based information. CONCLUSIONS: This study is the first to evaluate the current availability and quality of mobile apps designed for cannabis cessation. Unlike previous research that broadly assessed cannabis-related mobile apps, this study focuses on the limited number of free cannabis cessation tools, reflecting what is most available to the general population. The findings highlight a significant gap between the growing demand for virtual cessation tools and the quality of existing options. With the rising global prevalence of cannabis use disorders, there is an increasing need for robust, accessible, and evidence-based therapeutic options. While mobile health apps may be a viable option to support cannabis cessation, the current landscape is limited by poor quality apps and a lack of evidence-based information. From a real-world perspective, this study highlights the need for users to exercise caution when relying on current cannabis cessation apps and underscores the urgent need for the development and evaluation of new evidence-based digital interventions. CI - (c)Siddharth Seth, Sumedha Kushwaha, Reshma Prashad, Michael Chaiton. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org), 14.05.2026. FAU - Seth, Siddharth AU - Seth S AUID- ORCID: 0009-0003-1216-5152 AD - Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. AD - Centre for Addiction and Mental Health, Toronto, ON, Canada. FAU - Kushwaha, Sumedha AU - Kushwaha S AUID- ORCID: 0000-0001-9145-7257 AD - Centre for Addiction and Mental Health, Toronto, ON, Canada. AD - Institute of Medical Science, University of Toronto, Toronto, ON, Canada. FAU - Prashad, Reshma AU - Prashad R AUID- ORCID: 0000-0002-1130-1808 AD - Faculty of Health Sciences, Ontario Tech University, Oshawa, ON, Canada. FAU - Chaiton, Michael AU - Chaiton M AUID- ORCID: 0000-0002-9589-2122 AD - Centre for Addiction and Mental Health, Toronto, ON, Canada. AD - Institute of Medical Science, University of Toronto, Toronto, ON, Canada. AD - Dalla Lana School of Public health, University of Toronto, Toronto, ON, Canada. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20260514 PL - Canada TA - JMIR Mhealth Uhealth JT - JMIR mHealth and uHealth JID - 101624439 SB - IM MH - *Mobile Applications/standards/statistics & numerical data MH - *Marijuana Abuse/economics/therapy MH - Smartphone MH - *Marijuana Smoking/economics/therapy MH - Canada MH - *Smoking Cessation/economics/methods/statistics & numerical data MH - Humans MH - *Digital Health/standards/statistics & numerical data MH - Young Adult MH - Adolescent MH - Adult MH - Time Factors MH - Evidence-Based Practice/methods/standards PMC - PMC13219983 OTO - NOTNLM OT - cannabis OT - cessation OT - mHealth interventions OT - mobile apps OT - mobile health interventions COIS- Conflicts of Interest: None declared. EDAT- 2026/05/14 18:36 MHDA- 2026/05/14 18:37 PMCR- 2026/05/14 CRDT- 2026/05/14 16:53 PHST- 2024/04/21 00:00 [received] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/05/14 18:37 [medline] PHST- 2026/05/14 18:36 [pubmed] PHST- 2026/05/14 16:53 [entrez] PHST- 2026/05/14 00:00 [pmc-release] AID - v14i1e58908 [pii] AID - 10.2196/58908 [doi] PST - epublish SO - JMIR Mhealth Uhealth. 2026 May 14;14:e58908. doi: 10.2196/58908. PMID- 42133083 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 6 DP - 2026 May 14 TI - Association of compliance-normalized airway and transpulmonary mechanical power with mortality in PARDS. LID - 393 [pii] LID - 10.1007/s00431-026-07048-5 [doi] AB - The prognostic significance of mechanical power (MP) and the optimal normalization strategy in pediatric acute respiratory distress syndrome (PARDS) remains uncertain. We evaluated the association between airway and transpulmonary mechanical power normalized using different strategies and 28-day mortality in children with PARDS. In this multicenter retrospective observational study, 128 invasively ventilated subjects with PARDS were included from four tertiary pediatric intensive care units between June 2020 and December 2025. Airway MP and transpulmonary mechanical power (MPL) were calculated during pressure-controlled ventilation and normalized to predicted body weight (PBW), body surface area (BSA), and static respiratory system compliance (Cstat). The primary outcome was 28-day mortality. Associations were examined using multivariable logistic regression adjusted for age, sex, ARDS severity (PALICC-2), and Pediatric Index of Mortality-3 (PIM-3). Discriminative performance was assessed using receiver operating characteristic analysis with DeLong comparisons, and optimal thresholds were identified using the Youden index. The 28-day mortality rate was 20.3%. Absolute airway MP was not associated with mortality. In adjusted analyses, only compliance-normalized airway MP (MP/Cstat) was associated with mortality (adjusted OR 6.8, 95% CI 1.0-44.8; p = 0.044). Compliance-normalized transpulmonary MP (MPL/Cstat) was also associated with mortality (adjusted OR 30.6, 95% CI 1.5-615.7; p = 0.03). PBW- and BSA-normalized indices were not significant. Compliance-normalized indices showed numerically higher AUC values (MP/Cstat 0.68; MPL/Cstat 0.70), although the differences were not significant by DeLong testing. Mortality increased stepwise across MP/Cstat tertiles (p for trend = 0.01). Among MP components, only the compliance-normalized elastic component was significantly associated with mortality. CONCLUSIONS: Mechanical power, normalized to static respiratory system compliance rather than anthropometric parameters, was associated with mortality and showed a graded dose-response relationship in PARDS. Compliance-based normalization may provide additional physiological insight into mechanical power assessment in PARDS. WHAT IS KNOWN: * Mechanical power integrates multiple ventilatory variables and has been associated with outcomes in adult ARDS. * Different normalization approaches, including anthropometric and physiologic methods, have been proposed to account for variability in body size and lung mechanics. The clinical relevance of these normalization strategies in PARDS remains uncertain. WHAT IS NEW: * In a multicenter cohort of subjects with PARDS, mechanical power normalized to static respiratory system compliance was independently associated with 28-day mortality for both airway and transpulmonary measurements. In contrast, normalization to predicted body weight or body surface area was not independently associated with mortality after adjustment. * Mortality increased progressively across tertiles of compliance-normalized airway mechanical power. Among mechanical power components, only the compliance-normalized elastic component was independently associated with mortality. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Soydan, Ekin AU - Soydan E AUID- ORCID: 0000-0003-2626-5499 AD - Aydin Maternity and Children's Hospital, Pediatric Intensive Care Unit, Aydin, Turkey. dr-ekinsoydan@hotmail.com. FAU - Demirel, Ozlem AU - Demirel O AUID- ORCID: 0000-0002-8356-4383 AD - Aydin Maternity and Children's Hospital, Pediatric Intensive Care Unit, Aydin, Turkey. FAU - Yay, Ece Dorsan AU - Yay ED AUID- ORCID: 0009-0004-2114-7623 AD - Aydin Maternity and Children's Hospital, Pediatric Intensive Care Unit, Aydin, Turkey. FAU - Atakul, Gulhan AU - Atakul G AUID- ORCID: 0000-0002-3832-9691 AD - University of Health Sciences, Dr. Behcet Uz Children's Hospital, Pediatric Intensive Care Unit, Izmir, Turkey. FAU - Topal, Sevgi AU - Topal S AUID- ORCID: 0000-0002-7725-5509 AD - Acibadem University, Acibadem Altunizade Hospital, Pediatric Intensive Care Unit, Istanbul, Turkey. FAU - Colak, Mustafa AU - Colak M AUID- ORCID: 0000-0001-8310-3766 AD - University of Health Sciences, Cam Sakura Research and Training Hospital, Pediatric Intensive Care Unit, Istanbul, Turkey. FAU - Sarac, Ozlem AU - Sarac O AUID- ORCID: 0000-0002-5414-4670 AD - University of Health Sciences, Dr. Behcet Uz Children's Hospital, Pediatric Intensive Care Unit, Izmir, Turkey. FAU - Karaarslan, Utku AU - Karaarslan U AUID- ORCID: 0000-0002-3267-6983 AD - University of Health Sciences, Dr. Behcet Uz Children's Hospital, Pediatric Intensive Care Unit, Izmir, Turkey. FAU - Agin, Hasan AU - Agin H AUID- ORCID: 0000-0003-3306-8899 AD - University of Health Sciences, Dr. Behcet Uz Children's Hospital, Pediatric Intensive Care Unit, Izmir, Turkey. FAU - Ceylan, Gokhan AU - Ceylan G AUID- ORCID: 0000-0002-1730-6968 AD - University of Health Sciences, Dr. Behcet Uz Children's Hospital, Pediatric Intensive Care Unit, Izmir, Turkey. LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260514 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Female MH - Male MH - Retrospective Studies MH - *Respiratory Distress Syndrome/mortality/therapy/physiopathology MH - Child, Preschool MH - Infant MH - Child MH - Lung Compliance MH - *Respiration, Artificial/methods MH - Prognosis MH - Intensive Care Units, Pediatric MH - ROC Curve OTO - NOTNLM OT - Lung compliance OT - Mechanical power OT - Mechanical ventilation OT - Mortality OT - Normalization OT - Pediatric ARDS OT - Transpulmonary pressure COIS- Declarations. Ethics approval: The study was approved by the Institutional Review Board of Behcet Uz Children's Hospital (Protocol No: 02020/431; Approval Date: January 25, 2020). All participating centers obtained local institutional approval. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/14 14:49 MHDA- 2026/05/14 14:50 CRDT- 2026/05/14 11:16 PHST- 2026/03/22 00:00 [received] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/04/25 00:00 [revised] PHST- 2026/05/14 14:50 [medline] PHST- 2026/05/14 14:49 [pubmed] PHST- 2026/05/14 11:16 [entrez] AID - 10.1007/s00431-026-07048-5 [pii] AID - 10.1007/s00431-026-07048-5 [doi] PST - epublish SO - Eur J Pediatr. 2026 May 14;185(6):393. doi: 10.1007/s00431-026-07048-5. PMID- 42133072 OWN - NLM STAT- MEDLINE DCOM- 20260822 LR - 20261008 IS - 1437-1596 (Electronic) IS - 0937-9827 (Linking) VI - 140 IP - 5 DP - 2026 Sep TI - Comparing an Indian dataset with BioAlder using Demirjian's staging of the third molar. PG - 3057-3066 LID - 10.1007/s00414-026-03828-8 [doi] AB - This study evaluated third molar development in a northern Indian dataset from Uttar Pradesh (UP) using Demirjian staging and compared the results with another northern Indian dataset from Rajasthan (RS) and with the BioAlder model. The inter-rater reliability in the UP dataset was assessed using linear weighted Cohen's kappa and showed strong agreement. Development patterns were compared conditional on age to avoid age-mimicry bias: UP versus RS was assessed using age-stratified Fisher's exact tests and an overall ordinal-regression likelihood ratio test, and UP versus BioAlder was assessed using G-tests across all ages and within age groups. The UP versus RS datasets differed significantly overall, but age-specific differences were confined to isolated ages (12 years in males and 13 years in females). In contrast, UP diverged substantially from BioAlder, including higher stage H probabilities around age 18. Using Bayesian inversion with identical uniform age priors, the UP model yielded two- to threefold higher probabilities of being below key forensic thresholds than BioAlder: P(Age < 16|G) and P(Age < 18|H). These findings indicate that direct application of BioAlder to this Indian dataset would systematically underestimate the probability of being underage, increasing the risk of classifying minors as adults. For stage H, posterior probabilities were highly sensitive to the prior's upper age bound; in our analysis, the upper bound had a greater impact on the resulting probabilities than the difference between the reference datasets. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Bleka, Oyvind AU - Bleka O AUID- ORCID: 0000-0001-8456-1507 AD - Department of Forensic Sciences, Oslo University Hospital, Oslo, Norway. FAU - Khare, Parul AU - Khare P AUID- ORCID: 0000-0001-5773-015X AD - School of Dental Sciences, Sharda University, Greater Noida, Uttar Pradesh, India. Parul.khare@sharda.ac.in. FAU - Kvaal, Sigrid I AU - Kvaal SI AUID- ORCID: 0000-0002-3825-9048 AD - Faculty of Dentistry, University of Oslo, Oslo, Norway. FAU - Siddharth, M AU - Siddharth M AUID- ORCID: 0000-0001-5233-7092 AD - School of Dental Sciences, Sharda University, Greater Noida, Uttar Pradesh, India. FAU - Rastogi, Pooja AU - Rastogi P AUID- ORCID: 0000-0002-2750-1943 AD - Department of Forensic Medicine & Toxicology, Kalyan Singh Government Medical College, Bulandshahr, Uttar Pradesh, India. FAU - Kopperud, Simen E AU - Kopperud SE AUID- ORCID: 0000-0003-4689-4452 AD - Faculty of Dentistry, University of Oslo, Oslo, Norway. LA - eng GR - NA/NA/ PT - Comparative Study PT - Journal Article DEP - 20260514 PL - Germany TA - Int J Legal Med JT - International journal of legal medicine JID - 9101456 SB - IM MH - Humans MH - Male MH - Child MH - *Age Determination by Teeth/methods MH - Female MH - *Molar, Third/growth & development/diagnostic imaging MH - Adolescent MH - India MH - Bayes Theorem MH - Reproducibility of Results MH - Forensic Dentistry/methods MH - Datasets as Topic EDAT- 2026/05/14 14:50 MHDA- 2026/08/22 22:41 CRDT- 2026/05/14 11:15 PHST- 2025/12/22 00:00 [received] PHST- 2026/04/25 00:00 [accepted] PHST- 2026/08/22 22:41 [medline] PHST- 2026/05/14 14:50 [pubmed] PHST- 2026/05/14 11:15 [entrez] AID - 10.1007/s00414-026-03828-8 [pii] AID - 10.1007/s00414-026-03828-8 [doi] PST - ppublish SO - Int J Legal Med. 2026 Sep;140(5):3057-3066. doi: 10.1007/s00414-026-03828-8. Epub 2026 May 14. PMID- 42131588 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260514 LR - 20260813 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 13 DP - 2026 TI - Development and validation of a risk prediction model for dry eye disease in myopic children. PG - 1768592 LID - 10.3389/fmed.2026.1768592 [doi] LID - 1768592 AB - INTRODUCTION: To identify independent risk factors for dry eye disease (DED) and to develop and validate a predictive model for DED among myopic schoolchildren aged 8-16 years in northern China. METHODS: A cross-sectional study was conducted among myopic children in Zhangjiakou, Hebei Province. The children underwent comprehensive ocular surface evaluations, including corneal fluorescein staining, tear film break-up time (FBUT), Schirmer I test, lipid layer thickness (LLT), and partial blink rate (PBR). DED was diagnosed using the 2022 Chinese Expert Consensus criteria. Behavioral and environmental risk factors were assessed via validated questionnaires. Logistic regression identified independent factors, and a nomogram was constructed and validated for individualized DED risk estimation. RESULTS: A total of 1,303 myopic children were included for analysis, and the prevalence of objectively diagnosed DED was 31.2%. Tear film instability, reduced LLT, and increased PBR were the predominant ocular surface abnormalities. The children were divided into training and validation sets according to the community. Among the 912 children in the training set, multivariate analysis identified orthokeratology (Ortho-K) lens use (OR = 4.74), daily screen time >/= 4 h (OR = 4.21), near work >/= 4 h (OR = 3.53), BMI >/= 24 (OR = 3.20), and sleep duration < 6 h (OR = 2.26) as independent risk factors (all p < 0.05). The risk prediction nomogram demonstrated acceptable discriminative ability (AUC: 0.74 in the training set and 0.70 in the validation set). CONCLUSION: Dry eye disease is common and under-recognized among myopic children in northern China, with risk closely linked to modifiable behavioral and lifestyle factors and Ortho-K lens use. The developed nomogram can facilitate early identification and targeted interventions for high-risk children. CI - Copyright (c) 2026 Li, Wen, Qin, Gao, Liu and Zhang. FAU - Li, Bingqing AU - Li B AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. AD - Department of Refraction, Shijiazhuang Aier Eye Hospital, Shijiazhuang, China. FAU - Wen, Jie AU - Wen J AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. FAU - Qin, Jie AU - Qin J AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. FAU - Gao, Ran AU - Gao R AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. FAU - Liu, Hanruo AU - Liu H AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. FAU - Zhang, Fengju AU - Zhang F AD - Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. AD - Department of Refraction, Beijing Aier-Intech Eye Hospital, Beijing, China. LA - eng PT - Journal Article DEP - 20260428 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC13162332 OTO - NOTNLM OT - blink OT - body mass index OT - child OT - dry eye disease OT - myopia OT - orthokeratologic procedures OT - predictive value of tests OT - risk factors COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/14 14:21 MHDA- 2026/05/14 14:22 PMCR- 2026/04/28 CRDT- 2026/05/14 04:55 PHST- 2025/12/16 00:00 [received] PHST- 2026/03/25 00:00 [revised] PHST- 2026/04/06 00:00 [accepted] PHST- 2026/05/14 14:22 [medline] PHST- 2026/05/14 14:21 [pubmed] PHST- 2026/05/14 04:55 [entrez] PHST- 2026/04/28 00:00 [pmc-release] AID - 10.3389/fmed.2026.1768592 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Apr 28;13:1768592. doi: 10.3389/fmed.2026.1768592. eCollection 2026. PMID- 42131447 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260514 LR - 20260813 IS - 2632-2897 (Electronic) IS - 2632-2897 (Linking) VI - 7 DP - 2026 TI - Machine learning identifies differences between breast milk and formula in the gut microbiome. PG - e7 LID - 10.1017/gmb.2026.10020 [doi] LID - e7 AB - In this study, we analysed differences in the infant gut microbiome between breastfed and formula-fed infants using novel machine learning techniques. Breast milk, rich in bioactive agents, supports microbiota composition and immune development, while formulas aim to replicate its nutritional profile. We applied a methodology combining the DADA2 pipeline for 16S rRNA sequencing with the Recursive Ensemble Feature Selection (REFS) algorithm for biomarker discovery. We analysed three publicly available 16S rRNA datasets: PRJNA633365 (70 stool samples from China), PRJDB7295 (40 stool samples from the Philippines), and PRJNA562650 (40 stool samples from China). The discovery dataset (PRJNA633365) revealed 16 significant taxa out of 1,227, validated across the other two datasets. Next, we compared REFS performance with another feature selection algorithm, SelectKBest. Finally, we conducted a literature review to explore links between identified taxa and medical conditions. Additionally, we used MicrobiomeAnalyst to examine associations with diseases, diet, and lifestyle. Our results show differences in the bacterial composition between breastfed and formula-fed infants, and these findings were validated in two independent datasets. Future research should explore the functional roles of these taxa and consider regional and dietary variability to enhance understanding of microbiome dynamics and long-term health outcomes. CI - (c) The Author(s) 2026. FAU - Chia Liu, Ting AU - Chia Liu T AD - Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht, The Netherlands. ROR: https://ror.org/04pp8hn57 FAU - Rojas-Velazquez, David AU - Rojas-Velazquez D AUID- ORCID: 0000-0003-4402-4736 AD - Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht, The Netherlands. ROR: https://ror.org/04pp8hn57 AD - Department of Data Science, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands. FAU - Kidwai, Sarah AU - Kidwai S AD - Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht, The Netherlands. ROR: https://ror.org/04pp8hn57 FAU - Hogenkamp, Astrid AU - Hogenkamp A AD - Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht, The Netherlands. ROR: https://ror.org/04pp8hn57 FAU - Garssen, Johan AU - Garssen J AD - Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht, The Netherlands. ROR: https://ror.org/04pp8hn57 AD - Danone Global Research & Innovation Center, Utrecht, The Netherlands. ROR: https://ror.org/04hxnp039 FAU - Kraneveld, Aletta D AU - Kraneveld AD AD - Department of Neuroscience, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. FAU - Lopez-Rincon, Alejandro AU - Lopez-Rincon A AD - Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht, The Netherlands. ROR: https://ror.org/04pp8hn57 LA - eng PT - Journal Article DEP - 20260508 PL - England TA - Gut Microbiome (Camb) JT - Gut microbiome (Cambridge, England) JID - 9918556685506676 PMC - PMC13161719 OTO - NOTNLM OT - biomarker discovery OT - deep learning OT - feature selection OT - machine learning COIS- J.G. is employed in part by the company Danone Nutricia Research. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/14 14:21 MHDA- 2026/05/14 14:22 PMCR- 2026/05/08 CRDT- 2026/05/14 04:53 PHST- 2025/07/18 00:00 [received] PHST- 2026/02/17 00:00 [revised] PHST- 2026/02/21 00:00 [accepted] PHST- 2026/05/14 14:22 [medline] PHST- 2026/05/14 14:21 [pubmed] PHST- 2026/05/14 04:53 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - S2632289726100206 [pii] AID - 10.1017/gmb.2026.10020 [doi] PST - epublish SO - Gut Microbiome (Camb). 2026 May 8;7:e7. doi: 10.1017/gmb.2026.10020. eCollection 2026. PMID- 42131230 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260514 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Food insecurity as an underexplored pathway linking ethnic enclave contexts and anxiety among Dominicans in the United States. PG - 1778246 LID - 10.3389/fnut.2026.1778246 [doi] LID - 1778246 AB - INTRODUCTION: Migration shapes access to food environments and practices, with implications for both nutritional and mental health. Although neighborhood ethnic concentration has been linked to mental health among Latino populations, the findings remain inconsistent, and the mechanisms are not well understood. Food insecurity, a common experience among immigrant households, may represent a key psychosocial pathway linking the neighborhood context to anxiety. Caribbean Latino populations, including Dominicans, remain underrepresented in this literature. This study examined whether Dominican ethnic concentration is associated with anxiety symptoms and whether household food insecurity mediates this relationship. METHODS: We analyzed data from a representative multi-state sample of Dominican adults in the United States (n = 662), 53% of whom were immigrants. Dominican ethnic concentration was operationalized using location quotients at the ZIP Code Tabulation Area level to capture enclave-like contexts in the data. Household food insecurity was assessed using a validated measure (low/very low; mild/high), and anxiety symptoms were measured using the Generalized Anxiety Disorder-4 scale (0 = not at all to 4 = nearly every day). Survey-weighted generalized structural equation models were used to test mediation, adjusting for age, sex, income, nativity, state of residence, and presence of children in the household. RESULTS: Nearly 30% of the respondents experienced low household food security. Higher Dominican ethnic concentration was associated with lower anxiety symptoms overall, with mean GAD-4 scores being highest in low-concentration areas and lower in higher-concentration and ethnic enclaves. In survey-weighted generalized structural equation models, low household food security was strongly associated with higher anxiety symptoms (beta = 0.586, P < 0.001). Mediation analysis indicated that household food security partially mediated the association between Dominican concentration and anxiety (p = 0.034). DISCUSSION: Greater Dominican concentration may protect against anxiety by reducing household food insecurity, highlighting food insecurity as a key pathway linking ethnic concentration to mental health. These findings underscore the importance of culturally sustaining food environments for the wellbeing of immigrants and subsequent generations born in the US. CI - Copyright (c) 2026 Florez, Bi, D'Agostino, Agarwal, Albrecht, Marrara, Abraido-Lanza and Hernandez. FAU - Florez, Karen R AU - Florez KR AD - Graduate School of Public Health and Health Policy (CUNY SPH), Center for Systems Science and Community Design, City University of New York, New York, NY, United States. FAU - Bi, Yuntian AU - Bi Y AD - Nicholas School of the Environment, Duke University, Durham, NC, United States. FAU - D'Agostino, Emily M AU - D'Agostino EM AD - Department of Population Health Sciences, Duke University School of Medicine, Durham, NC, United States. AD - Duke Center for Childhood Obesity Research, Duke University School of Medicine, Durham, NC, United States. AD - Department of Orthopedic Surgery, Occupational Therapy Division, Duke University School of Medicine, Durham, NC, United States. AD - Duke Clinical Research Institute, Duke University School of Medicine, Durham, NC, United States. AD - Duke Global Health Institute, Duke University School of Medicine, Durham, NC, United States. FAU - Agarwal, Khushboo R AU - Agarwal KR AD - Graduate School of Public Health and Health Policy (CUNY SPH), Epidemiology and Biostatistics, City University of New York, New York, NY, United States. FAU - Albrecht, Sandra S AU - Albrecht SS AD - Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY, United States. FAU - Marrara, Sarah AU - Marrara S AD - School of Social Work, Columbia University, New York, NY, United States. FAU - Abraido-Lanza, Ana F AU - Abraido-Lanza AF AD - School of Social Work, Columbia University, New York, NY, United States. FAU - Hernandez, Ramona AU - Hernandez R AD - City College of New York, CUNY Dominican Studies Institute, New York, NY, United States. LA - eng PT - Journal Article DEP - 20260428 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13160777 OTO - NOTNLM OT - Dominican immigrants OT - anxiety OT - food insecurity OT - neighborhoods OT - residential segregation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/14 14:21 MHDA- 2026/05/14 14:22 PMCR- 2026/04/28 CRDT- 2026/05/14 04:51 PHST- 2025/12/30 00:00 [received] PHST- 2026/03/15 00:00 [revised] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/05/14 14:22 [medline] PHST- 2026/05/14 14:21 [pubmed] PHST- 2026/05/14 04:51 [entrez] PHST- 2026/04/28 00:00 [pmc-release] AID - 10.3389/fnut.2026.1778246 [doi] PST - epublish SO - Front Nutr. 2026 Apr 28;13:1778246. doi: 10.3389/fnut.2026.1778246. eCollection 2026. PMID- 42130456 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260723 IS - 2191-0251 (Electronic) IS - 0334-018X (Linking) VI - 39 IP - 7 DP - 2026 Jul 24 TI - Parent-perceived stressors and stress-dosing practices during suspected adrenal crisis in children with congenital adrenal hyperplasia: a cross-sectional, parent-reported study. PG - 670-680 LID - 10.1515/jpem-2025-0604 [doi] AB - OBJECTIVES: Adrenal crisis (AC) is a life-threatening complication in children with congenital adrenal hyperplasia (CAH). While physiological stressors are well-recognized precipitants, the contribution of psycho-emotional stressors remains poorly understood. This study evaluated the prevalence of parent-reported adrenal crises associated with psycho-emotional stressors in children with CAH and examined associations with child age, sex, and CAH phenotype. METHODS: This cross-sectional observational study enrolled parents of children under 18 years of age with CAH living in the United States (IRB H25-0397; n=131). Parent-perceived psycho-emotional adrenal crisis (PEAC) prevalence was assessed, and associations with child age, sex, and phenotype were evaluated. Parents also reported perceived triggers, symptoms, and management strategies for suspected PEAC events. RESULTS: A total of 115 parents representing 118 children with clinically diagnosed CAH participated. Children were predominantly female (58.5 %), had a median age of 6 years, and most had salt-wasting CAH (76.1 %). Lifetime parent-reported AC prevalence was 85.5 %, with 47.0 % reporting at least one AC in the prior year. Suspected PEAC events were reported in 24.3 % of children, and 11.3 % experienced a suspected event within the previous 12 months. Overall AC rates did not differ by sex; however, recent suspected PEAC events were more frequently reported in female children. Half of parents reported proactively increasing glucocorticoid doses during psycho-emotional stress, a practice strongly associated with prior PEAC history. Most suspected PEAC episodes were managed at home, though approximately one-third required emergency medical care. CONCLUSIONS: Psycho-emotional stressors may contribute to suspected adrenal crises in children with CAH, particularly among female or older children. Further research involving both parents and clinicians is needed to validate these findings and to optimize guidance for PEAC recognition and management. CI - (c) 2026 Walter de Gruyter GmbH, Berlin/Boston. FAU - Cubberley, Sarah K AU - Cubberley SK AD - Department of Clinical Research, School of Nursing, University of North Carolina Wilmington, Wilmington, NC, USA. FAU - Minns, Laurie A AU - Minns LA AD - Department of Clinical Research, School of Nursing, University of North Carolina Wilmington, Wilmington, NC, USA. LA - eng PT - Journal Article PT - Observational Study DEP - 20260515 PL - Germany TA - J Pediatr Endocrinol Metab JT - Journal of pediatric endocrinology & metabolism : JPEM JID - 9508900 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - *Adrenal Hyperplasia, Congenital/psychology/drug therapy/complications MH - Male MH - Child MH - *Parents/psychology MH - *Stress, Psychological/psychology MH - Child, Preschool MH - Adolescent MH - Follow-Up Studies MH - Subjective Stress MH - Prognosis MH - Infant MH - Prevalence MH - *Adrenal Insufficiency/etiology/psychology/drug therapy OTO - NOTNLM OT - adrenal crisis OT - congenital adrenal hyperplasia OT - glucocorticoids OT - psychological OT - stress EDAT- 2026/05/14 06:51 MHDA- 2026/07/08 01:10 CRDT- 2026/05/14 04:23 PHST- 2025/10/21 00:00 [received] PHST- 2026/04/26 00:00 [accepted] PHST- 2026/07/08 01:10 [medline] PHST- 2026/05/14 06:51 [pubmed] PHST- 2026/05/14 04:23 [entrez] AID - jpem-2025-0604 [pii] AID - 10.1515/jpem-2025-0604 [doi] PST - epublish SO - J Pediatr Endocrinol Metab. 2026 May 15;39(7):670-680. doi: 10.1515/jpem-2025-0604. Print 2026 Jul 24. PMID- 42129371 OWN - NLM STAT- Publisher LR - 20260513 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 May 7 TI - Shared decision-making for preventive sports cardiology in youth with heart disease: a pilot study. LID - 10.1038/s41390-026-05012-5 [doi] AB - BACKGROUND: Many youth with heart disease remain inactive despite the recognized benefits of physical activity. Shared decision-making (SDM) between patients, families, and care teams has been proposed to support exercise guidance, but implementation models are scarce. This pilot study evaluated the feasibility, acceptability, and safety of the Young Heart and Sport Clinic, an SDM-based preventive sports cardiology consultation. METHODS: A prospective, single-center study enrolled participants (6-25 years) with heart disease. The consultation comprised: well-being assessment (patient-reported outcomes); sports cardiology evaluation (cardiopulmonary exercise test, electrocardiogram, echocardiography, spirometry, muscle strength testing, accelerometry); and multidisciplinary consultation (pediatric sports cardiologist, specialist nurse, adapted physical activity educator). The team reviewed findings and used a semi-structured interview to identify barriers, motivators, and goals for tailored exercise prescriptions. Post-consultation orientation included cardiac rehabilitation, community-based activity, or referral to other specialists. RESULTS: Of 35 referred patients, 34 completed the program. Families and cardiologists endorsed its relevance and feasibility. No exercise-related adverse events were reported. At 6-month, 82% adhered to recommendations; 53% engaged in community-based activity, 44% in cardiac rehabilitation. CONCLUSIONS: This pilot study supports the feasibility, safety, and acceptability of an SDM-based model integrating exercise guidance. This approach may help bridge gaps between adult guidelines and pediatric practice. IMPACT: A multidisciplinary, shared decision-making-based sports cardiology consultation is feasible, acceptable, and safe for youth with heart disease. This study introduces a pragmatic framework that adapts adult preventive cardiology guidelines to pediatric practice, addressing a major gap in structured exercise counseling and rehabilitation pathways for this population. Implementation of this model may improve physical activity adherence, long-term cardiovascular prevention, and quality of life in children and young adults living with heart disease. CI - (c) 2026. The Author(s). FAU - Petrault, Manon AU - Petrault M AD - Department of Pediatric and Congenital Cardiology, National M3C Reference Center for Complex Congenital Heart Disease, Bordeaux University Hospital, Pessac, France. FAU - Andrianoely, Mathieu AU - Andrianoely M AD - INSERM U1045, IHU Liryc, Electrophysiology and Heart Modelling Institute, University of Bordeaux, Pessac, France. AD - Just Coaching, Paris, France. FAU - Audie, Marion AU - Audie M AD - Department of Pediatric and Congenital Cardiology, National M3C Reference Center for Complex Congenital Heart Disease, Bordeaux University Hospital, Pessac, France. AD - Le Hillot Cardiac Rehabilitation Center, Pessac, France. FAU - Werner, Oscar AU - Werner O AD - INSERM U1045, IHU Liryc, Electrophysiology and Heart Modelling Institute, University of Bordeaux, Pessac, France. AD - Department of Pediatric Cardiology and Pediatric Cardiac Surgery, FHU PRECICARE, Nantes University Hospital, Nantes, France. FAU - Lagorce, Stephanie AU - Lagorce S AD - Department of Pediatric and Congenital Cardiology, National M3C Reference Center for Complex Congenital Heart Disease, Bordeaux University Hospital, Pessac, France. FAU - Froger, Stephanie AU - Froger S AD - Siel Bleu Organization, Bordeaux, France. FAU - Chabaneix, Julie AU - Chabaneix J AD - Department of Pediatric and Congenital Cardiology, National M3C Reference Center for Complex Congenital Heart Disease, Bordeaux University Hospital, Pessac, France. AD - ATENA Registry, Bordeaux University Hospital, Bordeaux, France. FAU - Hasselot, Julien AU - Hasselot J AD - Patient Advocacy Organization "Les Liens Du Coeur", Pessac, France. FAU - Jouenne, Yannick AU - Jouenne Y AD - Patient Advocacy Organization "Les Liens Du Coeur", Pessac, France. FAU - Jore, Cecile AU - Jore C AD - Department of Pediatric and Congenital Cardiology, National M3C Reference Center for Complex Congenital Heart Disease, Bordeaux University Hospital, Pessac, France. FAU - Viton Le Mao, Lisa AU - Viton Le Mao L AD - Department of Pediatric and Congenital Cardiology, National M3C Reference Center for Complex Congenital Heart Disease, Bordeaux University Hospital, Pessac, France. FAU - Apheceixborde, Marc AU - Apheceixborde M AD - Department of Pediatric and Congenital Cardiology, National M3C Reference Center for Complex Congenital Heart Disease, Bordeaux University Hospital, Pessac, France. FAU - Iriart, Xavier AU - Iriart X AD - Department of Pediatric and Congenital Cardiology, National M3C Reference Center for Complex Congenital Heart Disease, Bordeaux University Hospital, Pessac, France. FAU - Mouton, Jean-Baptiste AU - Mouton JB AD - Department of Pediatric and Congenital Cardiology, National M3C Reference Center for Complex Congenital Heart Disease, Bordeaux University Hospital, Pessac, France. FAU - Gotchac, Julien AU - Gotchac J AD - Department of Pediatric and Congenital Cardiology, National M3C Reference Center for Complex Congenital Heart Disease, Bordeaux University Hospital, Pessac, France. AD - INSERM U1045, IHU Liryc, Electrophysiology and Heart Modelling Institute, University of Bordeaux, Pessac, France. FAU - Ferrer-Sargues, Francisco-Jose AU - Ferrer-Sargues FJ AD - Regeneration and Heart Transplant Research Group (RETRACAR), Health Research Institute La Fe (IISLAFE), Valencia, Spain. AD - Department of Physiotherapy, Universidad Cardenal Herrera CEU, CEU Universities, Valencia, Spain. FAU - Thambo, Jean-Benoit AU - Thambo JB AD - Department of Pediatric and Congenital Cardiology, National M3C Reference Center for Complex Congenital Heart Disease, Bordeaux University Hospital, Pessac, France. AD - INSERM U1045, IHU Liryc, Electrophysiology and Heart Modelling Institute, University of Bordeaux, Pessac, France. FAU - Amedro, Pascal AU - Amedro P AUID- ORCID: 0000-0003-3649-0294 AD - Department of Pediatric and Congenital Cardiology, National M3C Reference Center for Complex Congenital Heart Disease, Bordeaux University Hospital, Pessac, France. pascal.amedro@gmail.com. AD - INSERM U1045, IHU Liryc, Electrophysiology and Heart Modelling Institute, University of Bordeaux, Pessac, France. pascal.amedro@gmail.com. AD - Heart & Lung Center, Heart Research Institute, Children's National Hospital, Washington, DC, USA. pascal.amedro@gmail.com. AD - Department of Pediatrics, The George Washington University School of Medicine & Health Sciences, Washington, DC, USA. pascal.amedro@gmail.com. CN - QUALIREHAB study group LA - eng PT - Journal Article DEP - 20260507 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Consent for publication: Informed consent was obtained from all participants and/or their legal guardians. FIR - Guillaumont, Sophie IR - Guillaumont S FIR - Oubari, Omar IR - Oubari O FIR - Bourreau, Jerome IR - Bourreau J FIR - Calderon, Johanna IR - Calderon J FIR - Moniotte, Stephane IR - Moniotte S FIR - Hubrechts, Jelena IR - Hubrechts J FIR - Peiro-Molina, Esteban IR - Peiro-Molina E FIR - Rezola, Erika IR - Rezola E FIR - Manso, Begona IR - Manso B FIR - Onoro, Gonzalo IR - Onoro G FIR - Bordessoule, Alice IR - Bordessoule A FIR - Gavotto, Arthur IR - Gavotto A FIR - Matecki, Stephan IR - Matecki S FIR - Neyraud, Caroline IR - Neyraud C FIR - Huby, Anne-Cecile IR - Huby AC FIR - Tortigue, Marine IR - Tortigue M FIR - Venna, Alyssia IR - Venna A FIR - Desir, Arielle IR - Desir A FIR - Hershenson, Jared IR - Hershenson J FIR - Burton, Justin IR - Burton J EDAT- 2026/05/14 00:31 MHDA- 2026/05/14 00:31 CRDT- 2026/05/13 23:38 PHST- 2025/10/28 00:00 [received] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/02/25 00:00 [revised] PHST- 2026/05/14 00:31 [medline] PHST- 2026/05/14 00:31 [pubmed] PHST- 2026/05/13 23:38 [entrez] AID - 10.1038/s41390-026-05012-5 [pii] AID - 10.1038/s41390-026-05012-5 [doi] PST - aheadofprint SO - Pediatr Res. 2026 May 7. doi: 10.1038/s41390-026-05012-5. PMID- 42128497 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 5 DP - 2026 May 13 TI - HealthyPregnancy: development and feasibility of a digital care guide to promote recommended gestational weight gain in pregnant women living with overweight in Denmark. PG - e112204 LID - 10.1136/bmjopen-2025-112204 [doi] LID - e112204 AB - OBJECTIVES: Excessive gestational weight gain increases the risk of complications in pregnancy, childbirth and later in life among pregnant women living with overweight and their offspring. Therefore, this study aimed to develop and examine the feasibility of a digital intervention supporting recommended gestational weight gain and the recommended level of physical activity, targeting pregnant women with a body mass index (BMI) of 27 or above. DESIGN: Intervention development was guided by the Medical Research Council guideline on the development and evaluation of complex interventions, and subsequent feasibility testing was conducted in a non-randomised design. SETTING: The obstetric department at Copenhagen University Hospital-North Zealand, Denmark. PARTICIPANTS: 98 pregnant women living with overweight participated in feasibility testing. INTERVENTIONS: The intervention developed in this study was a mobile phone application with a digital care guide containing text and video information supporting recommended gestational weight gain and physical activity levels. The video material featured multiple healthcare professionals and a pregnant woman from the target group. MAIN OUTCOME MEASURES: The main feasibility measures were participant recruitment and engagement with the digital care guide throughout pregnancy. RESULTS: Recruitment rates were satisfactory, with 69% of eligible pregnant women consenting to participation. The participants used the application and engaged with the digital care guide; however, use of the care guide diminished as pregnancy progressed. CONCLUSIONS: We developed a digital care guide supporting recommended gestational weight gain and physical activity levels for pregnant women with a BMI of 27 or higher. Feasibility testing indicated that there is sufficient interest in participating in a study promoting recommended weight gain and physical activity to warrant a larger effectiveness trial. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Hansen, Mette Kabell AU - Hansen MK AUID- ORCID: 0000-0001-5393-1552 AD - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg University Hospital, Frederiksberg, Denmark mette.kabell.hansen@regionh.dk. FAU - Bendix, Jane Marie AU - Bendix JM AD - Department of Gynecology and Obstetrics, Nordsjaellands Hospital, Hillerod, Denmark. FAU - Lokkegaard, Ellen Christine Leth AU - Lokkegaard ECL AUID- ORCID: 0000-0003-4149-5663 AD - Department of Gynecology and Obstetrics, Nordsjaellands Hospital, Hillerod, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark. FAU - Schiotz, Michaela Louise AU - Schiotz ML AUID- ORCID: 0000-0002-2575-6686 AD - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg University Hospital, Frederiksberg, Denmark. AD - Department of Public Health, Research Unit of General Practice, University of Southern Denmark, Odense, Region Syddanmark, Denmark. FAU - Broberg, Lotte AU - Broberg L AUID- ORCID: 0000-0002-1778-7941 AD - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg University Hospital, Frederiksberg, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Capital Region of Denmark, Denmark. AD - Department of Gynecology and Obstetrics, Slagelse Hospital, Slagelse, Denmark. LA - eng PT - Journal Article DEP - 20260513 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Gestational Weight Gain MH - Denmark MH - Adult MH - Feasibility Studies MH - *Overweight/therapy MH - Exercise MH - Body Mass Index MH - *Pregnancy Complications/prevention & control MH - *Mobile Applications MH - *Prenatal Care/methods MH - Digital Health MH - Young Adult MH - *Health Promotion/methods PMC - PMC13182374 OTO - NOTNLM OT - Exercise OT - Feasibility Studies OT - Health OT - Mobile Applications OT - Overweight OT - Pregnancy COIS- Competing interests: All authors declare that they have no conflicts of interest. EDAT- 2026/05/14 00:31 MHDA- 2026/05/14 00:32 PMCR- 2026/05/13 CRDT- 2026/05/13 20:52 PHST- 2026/05/14 00:32 [medline] PHST- 2026/05/14 00:31 [pubmed] PHST- 2026/05/13 20:52 [entrez] PHST- 2026/05/13 00:00 [pmc-release] AID - bmjopen-2025-112204 [pii] AID - 10.1136/bmjopen-2025-112204 [doi] PST - epublish SO - BMJ Open. 2026 May 13;16(5):e112204. doi: 10.1136/bmjopen-2025-112204. PMID- 42128082 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260730 IS - 1531-5037 (Electronic) IS - 0022-3468 (Linking) VI - 61 IP - 8 DP - 2026 Aug TI - Do congenital heart diseases or chromosomal anomalies influence the surgical outcomes of esophagocoloplasty in esophageal atresia patients? PG - 163202 LID - S0022-3468(26)00285-X [pii] LID - 10.1016/j.jpedsurg.2026.163202 [doi] AB - BACKGROUND: Esophageal atresia (EA) is frequently associated with congenital heart disease (CHD) and chromosomal anomalies, mainly Down syndrome (DS). While these conditions affect outcomes following primary repair, their specific impact on esophageal substitution procedure remains poorly defined. This study aimed to evaluate the influence of CHD and chromosomal anomalies on surgical outcomes following esophagocoloplasty for failed repair of EA patients. METHODS: Retrospective study including patients who underwent esophagocoloplasty between January 2015 and January 2025 at a single center divided into 4 groups: HD (CHD and DS), D (isolated DS), H (isolated CHD) and C (isolated EA). Demographic, clinical and surgical data, postoperative complications, length of stay, and mortality were analyzed. RESULTS: 105 patients were included (mean age 31.2 months; 57.1% male). VACTERL-associated anomalies were present in 53.3% of patients, with CHD being the most frequent (33.3%). DS was identified in 7.6% of the cohort. Postoperative complications occurred in 40% of cases, (87.9% minor complications). Multivariate analysis demonstrated that CHD was independently associated with impaired postoperative weight gain (OR = 3.62; p = 0.008). DS was not associated with major complications or mortality, although a trend toward an increased risk of sepsis was observed. Overall mortality was 0.95% (one case). No significant differences in the incidence of major complications among the study groups were observed. CONCLUSIONS: CHD negatively affected postoperative nutritional recovery but did not increase major morbidity or mortality in esophagocoloplasty patients. Chromosomal anomalies did not compromise overall surgical safety, supporting the feasibility of esophagocoloplasty in this complex patient population. CI - Published by Elsevier Inc. FAU - Tannuri, Ana Cristina Aoun AU - Tannuri ACA AD - Pediatric Surgery and Liver Transplantation Division, University of Sao Paulo Medical School, Sao Paulo, Brazil. FAU - Abe Takahasi, Bianca Namie AU - Abe Takahasi BN AD - Pediatric Surgery and Liver Transplantation Division, University of Sao Paulo Medical School, Sao Paulo, Brazil. FAU - de Almeida Estrambk, Gabriel AU - de Almeida Estrambk G AD - Pediatric Surgery and Liver Transplantation Division, University of Sao Paulo Medical School, Sao Paulo, Brazil. FAU - Ortega Ramos, Grace Raira AU - Ortega Ramos GR AD - Pediatric Surgery and Liver Transplantation Division, University of Sao Paulo Medical School, Sao Paulo, Brazil. FAU - Saraiva Santos, Maria Eduarda AU - Saraiva Santos ME AD - Pediatric Surgery and Liver Transplantation Division, University of Sao Paulo Medical School, Sao Paulo, Brazil. FAU - de Lima Silva, Melissa AU - de Lima Silva M AD - Pediatric Surgery and Liver Transplantation Division, University of Sao Paulo Medical School, Sao Paulo, Brazil. FAU - Marques Dos Anjos, Raphaela AU - Marques Dos Anjos R AD - Pediatric Surgery and Liver Transplantation Division, University of Sao Paulo Medical School, Sao Paulo, Brazil. FAU - Troici, Vinicius Camargo AU - Troici VC AD - Pediatric Surgery and Liver Transplantation Division, University of Sao Paulo Medical School, Sao Paulo, Brazil. FAU - Reis Freitas, Joao Luis AU - Reis Freitas JL AD - Pediatric Surgery and Liver Transplantation Division, University of Sao Paulo Medical School, Sao Paulo, Brazil. FAU - Tannuri, Uenis AU - Tannuri U AD - Pediatric Surgery and Liver Transplantation Division, University of Sao Paulo Medical School, Sao Paulo, Brazil. Electronic address: uenist@usp.br. LA - eng PT - Journal Article DEP - 20260512 PL - United States TA - J Pediatr Surg JT - Journal of pediatric surgery JID - 0052631 SB - IM MH - Humans MH - *Esophageal Atresia/surgery/complications MH - Female MH - Retrospective Studies MH - *Heart Defects, Congenital/complications MH - Male MH - *Postoperative Complications/epidemiology/etiology MH - Infant MH - Treatment Outcome MH - *Down Syndrome/complications MH - Child, Preschool MH - *Esophagoplasty MH - *Esophagus/surgery/abnormalities MH - *Chromosome Aberrations MH - *Colon/surgery OTO - NOTNLM OT - Congenital heart disease OT - Esophageal atresia, Esophagocoloplasty OT - Surgical outcomes OT - Trisomy 21 COIS- Conflict of interests The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/14 00:31 MHDA- 2026/07/31 00:38 CRDT- 2026/05/13 19:12 PHST- 2026/03/10 00:00 [received] PHST- 2026/05/01 00:00 [revised] PHST- 2026/05/08 00:00 [accepted] PHST- 2026/07/31 00:38 [medline] PHST- 2026/05/14 00:31 [pubmed] PHST- 2026/05/13 19:12 [entrez] AID - S0022-3468(26)00285-X [pii] AID - 10.1016/j.jpedsurg.2026.163202 [doi] PST - ppublish SO - J Pediatr Surg. 2026 Aug;61(8):163202. doi: 10.1016/j.jpedsurg.2026.163202. Epub 2026 May 12. PMID- 42127649 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 201 DP - 2026 Aug TI - Impact of pediatric chronic kidney disease on brain integrity: A combined volumetric and MR spectroscopy analysis. PG - 112929 LID - S0720-048X(26)00277-9 [pii] LID - 10.1016/j.ejrad.2026.112929 [doi] AB - PURPOSE: Investigation of structural brain volume alterations and metabolic changes in stages 3-5 pCKD using volumetric MRI with MR spectroscopy. METHODS: In this cross-sectional study, 63 children with pCKD (stages 3-5; age range: 2-12 years), including 29 on dialysis and 34 not on dialysis, were compared to 63 age- and sex-matched healthy controls (age range: 3-11 years). All participants underwent brain MRI with automated volumetric segmentation (volBrain) and single-voxel spectroscopy to quantify N-acetylaspartate/creatine (NAA/Cr) and choline/creatine (Cho/Cr) ratios in the basal ganglia and pons. Group comparisons and correlation analyses between brain volumes and metabolite ratios were performed using independent t-tests, one-way ANOVA, Pearson/Spearman correlation, and analysis of covariance (ANCOVA) with grey matter volume as a covariate. RESULTS: Patients with pCKD (stage 3-5) demonstrated significant, widespread reductions in brain volume, affecting total brain, grey matter, cerebrum, cerebellum, and subcortical structures compared to controls (p < 0.05), with the most pronounced changes in the dialysis subgroup. Metabolically, pCKD patients showed significantly decreased NAA/Cr in the basal ganglia and increased Cho/Cr in both the basal ganglia and pons (p < 0.01), alterations that were most severe in dialysis patients. Crucially, pontine metabolite ratios correlated strongly with brain volumes: NAA/Cr showed a significant negative correlation (p = 0.01), while Cho/Cr showed a significant positive correlation(p = 0.014). Metabolic basal ganglia changes remained statistically significant after covariation for grey matter volume (p /=3.1 pg/mL, the 95th percentile of IL-6 levels in the healthy control group). Clinical, inflammatory, and lung function characteristics were compared between the two subgroups. Spearman's rank correlation analysis was conducted to explore the associations between cytokine levels and lung function/airway inflammation indices. Multivariate logistic regression analysis was performed to identify variables associated with asthma phenotypic characteristics, and subsequent feature selection was carried out using Least Absolute Shrinkage and Selection Operator (LASSO) regression with fivefold cross-validation. A priori sample size estimation and sex-stratified analyses were conducted, and all methods followed STROBE reporting guidelines. RESULTS: Compared with healthy controls, pediatric asthma patients had significantly elevated serum IgE levels, peripheral blood eosinophil counts, and plasma concentrations of IL-4, IL-6, and IL-12 (all p < 0.05). Among the asthma cohort, the "IL-6-high" subgroup (n = 20, 19.0%) had significantly higher body mass index (BMI) and plasma IL-12 levels relative to the "IL-6-normal" subgroup (n = 85). Sex-stratified analyses demonstrated consistent patterns of elevated IL-6-related airway inflammation and reduced lung function across male and female children, without significant subgroup divergence. Correlation analysis showed that plasma IL-4 levels were significantly negatively correlated with percent predicted forced expiratory volume in 1 s (FEV(1); r = -0.245, p = 0.025), and plasma IL-6 levels were significantly positively correlated with fractional exhaled nitric oxide (FeNO) levels (r = 0.214, p = 0.021). Multivariate logistic regression analysis identified asthma onset after 4 years of age, oral corticosteroid use, blood eosinophil count, FeNO level, and percent predicted FEV(1) as variables independently associated with asthma phenotypic characteristics. Notably, LASSO regression selected circulating IL-6 as the most prominent predictive biomarker for asthma phenotypic characteristics among all evaluated clinical, inflammatory, and lung function variables. A predictive nomogram incorporating key variables showed excellent discriminative performance in the training cohort (C-index = 0.85, 95%CI: 0.79-0.91) and was validated in an independent cohort (C-index = 0.82, 95%CI: 0.75-0.89). CONCLUSIONS: Elevated circulating IL-6 is a prominent feature associated with a distinct phenotypic subgroup of pediatric asthma, and is correlated with impaired lung function and increased airway inflammation in asthmatic children. These findings support the potential of IL-6 as a significant predictive biomarker for phenotypic risk stratification in pediatric asthma, and suggest its potential utility in phenotypic subtyping of asthmatic patients and as a promising therapeutic target for the IL-6-high pediatric asthma subgroup. All conclusions are interpreted cautiously, given the study's methodological limitations, and further large-cohort prospective validation is required. FAU - Liu, Yuyang AU - Liu Y AD - Department of pediatrics, Xi'an No.3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, China. FAU - Cheng, Lina AU - Cheng L AD - Department of Neonatology, Second Affiliated Hospital of Xi'an Medical College. FAU - Wang, Lu AU - Wang L AD - Department of pediatrics, Xi'an No.3 Hospital, the Affiliated Hospital of Northwest University, Xi'an, China. LA - eng PT - Journal Article PT - Observational Study DEP - 20260601 PL - England TA - J Asthma JT - The Journal of asthma : official journal of the Association for the Care of Asthma JID - 8106454 RN - 0 (Interleukin-6) RN - 0 (Biomarkers) RN - 0 (IL6 protein, human) SB - IM MH - Humans MH - *Asthma/blood/physiopathology/immunology/diagnosis/classification MH - *Interleukin-6/blood MH - Male MH - Female MH - Child MH - Cross-Sectional Studies MH - Biomarkers/blood MH - Adolescent MH - Risk Assessment MH - Respiratory Function Tests MH - Child, Preschool MH - Phenotype OAB - What is already known on this topicChildhood asthma is a heterogeneous condition, and systemic inflammation is only present in a subset of patients. While type 2 inflammatory biomarkers such as IL-4 are often elevated in asthma, the role of nontype 2 cytokines such as IL-6 remains less clearly defined in pediatric asthma.What this study addsThis study reveals that elevated IL-6 is a key feature associated with a distinct subgroup of children with asthma and is significantly correlated with impaired lung function and airway inflammation. Furthermore, IL-6 was identified as a prominent potential predictive biomarker among all evaluated inflammatory and clinical variables via LASSO regression, with a validated predictive model showing good discriminative ability. This provides a basis for its potential application in pediatric asthma phenotypic subtyping and risk stratification.How this study might affect research, practice or policyThese findings suggest that IL-6 could serve as a potential predictive biomarker for asthma phenotypic sub-phenotyping and a promising therapeutic target for the IL-6-high pediatric asthma subgroup. The results may guide more personalized phenotypic stratification and treatment strategies for this specific subgroup and inform future research into anti-cytokine therapies for severe or corticosteroid-resistant non-type 2 asthma in children. OABL- eng OTO - NOTNLM OT - Asthma OT - LASSO regression OT - biomarker OT - interleukin-6 OT - pediatrics OT - phenotypic stratification EDAT- 2026/05/13 06:32 MHDA- 2026/09/17 05:35 CRDT- 2026/05/13 05:03 PHST- 2026/09/17 05:35 [medline] PHST- 2026/05/13 06:32 [pubmed] PHST- 2026/05/13 05:03 [entrez] AID - 10.1080/02770903.2026.2666086 [doi] PST - ppublish SO - J Asthma. 2026 Oct;63(10):1317-1328. doi: 10.1080/02770903.2026.2666086. Epub 2026 Jun 1. PMID- 42125621 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260513 LR - 20260926 IS - 1687-9740 (Print) IS - 1687-9759 (Electronic) IS - 1687-9740 (Linking) VI - 2026 DP - 2026 TI - The Double Burden: Understanding the Impact of Malnutrition on Childhood Cancer Outcomes in Resource-Limited Settings. PG - 8860996 LID - 10.1155/ijpe/8860996 [doi] LID - 8860996 AB - Childhood cancer disproportionately affects low- and middle-income countries (LMICs), where over 80% of cases occur, and malnutrition affects approximately 70% of pediatric oncology patients, substantially compromising treatment tolerance, immune function, and survival. This review integrates current evidence on the impact of malnutrition in LMICs, evaluates assessment methodologies and interventions, and identifies knowledge gaps that hinder optimal nutritional care. The A-B-C-D (anthropometric, biochemical, clinical, and dietary assessments) framework provides a systematic assessment, with mid-upper arm circumference and handgrip dynamometry offering practical evaluation in resource-limited settings. Prealbumin is the most sensitive early biochemical marker (54%-87% sensitivity vs. 7.4%-45.8% for albumin), and nutritional screening tools like SCAN demonstrate high validity for risk identification (> 80% sensitivity and specificity). Interventions such as ready-to-use therapeutic foods improved weight gain (77.8% vs. 64.2%) and reduced severe infections (10.6% vs. 31%) in trials. We emphasize a multidisciplinary approach and research priorities centered on standardized assessments, long-term effects of malnutrition, and culturally appropriate nutritional programs for LMICs. CI - Copyright (c) 2026 Michael Asare-Baah and Michael Lauzardo. International Journal of Pediatrics published by John Wiley & Sons Ltd. FAU - Asare-Baah, Michael AU - Asare-Baah M AUID- ORCID: 0000-0003-2409-2061 AD - Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA, ufl.edu. AD - Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA, ufl.edu. FAU - Lauzardo, Michael AU - Lauzardo M AUID- ORCID: 0000-0002-7096-4185 AD - Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA, ufl.edu. AD - Division of Infectious Diseases and Global Medicine, College of Medicine, University of Florida, Gainesville, Florida, USA, ufl.edu. AD - Keira Grace Foundation, Gainesville, Florida, USA. LA - eng PT - Journal Article PT - Review DEP - 20260511 PL - United States TA - Int J Pediatr JT - International journal of pediatrics JID - 101517077 PMC - PMC13159538 OTO - NOTNLM OT - cancer outcomes OT - low- and middle-income countries OT - malnutrition OT - nutritional interventions OT - pediatric cancer OT - pediatric oncology COIS- The authors declare no conflicts of interest. EDAT- 2026/05/13 06:31 MHDA- 2026/05/13 06:32 PMCR- 2026/05/11 CRDT- 2026/05/13 04:46 PHST- 2025/02/12 00:00 [received] PHST- 2026/03/12 00:00 [revised] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/05/13 06:32 [medline] PHST- 2026/05/13 06:31 [pubmed] PHST- 2026/05/13 04:46 [entrez] PHST- 2026/05/11 00:00 [pmc-release] AID - IJPE8860996 [pii] AID - 10.1155/ijpe/8860996 [doi] PST - epublish SO - Int J Pediatr. 2026 May 11;2026:8860996. doi: 10.1155/ijpe/8860996. eCollection 2026. PMID- 42125593 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260513 LR - 20260813 IS - 0970-0218 (Print) IS - 1998-3581 (Electronic) IS - 0970-0218 (Linking) VI - 51 IP - 2 DP - 2026 Mar-Apr TI - Development of a Microsoft Excel Calculator for Infant and Young Child Feeding Indicators. PG - 419-422 LID - 10.4103/ijcm.ijcm_610_24 [doi] AB - The accurate assessment of infant and young child feeding (IYCF) practices is critical for evaluating nutritional status and guiding public health interventions. The study was planned to develop and validate a Microsoft Excel-based IYCF calculator based on the World Health Organization (WHO)-United Nations Children's Fund (UNICEF) 2021 IYCF indicators for its accuracy, consistency, and user-friendliness. The tool incorporated calculations of all 16 essential indicators. Logical and conditional functions were used to automate calculations. Validations were done using simulated and real databases from urban slums. The IYCF Excel Calculator was developed using Microsoft Excel on Windows 11 and compatible with Excel 2016 or later. The tool accurately calculated IYCF indicators and was user-friendly for individuals with basic knowledge of Microsoft Excel. It reduced the time and complexity of calculations. The developed Excel-based IYCF calculator is an accurate, accessible, and freely available tool for researchers and practitioners for academic and non-commercial use. CI - Copyright: (c) 2026 Indian Journal of Community Medicine. FAU - Sabale, Rupali AU - Sabale R AD - Department of Community Medicine, Seth GS Medical College and KEM Hospital, Maharashtra, India. FAU - Velhal, Gajanan AU - Velhal G AD - Department of Community Medicine, Seth GS Medical College and KEM Hospital, Maharashtra, India. LA - eng PT - Journal Article DEP - 20260326 PL - India TA - Indian J Community Med JT - Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine JID - 9315574 PMC - PMC13160210 OTO - NOTNLM OT - Excel calculator OT - Infant and Young Child Feeding (IYCF) OT - WHO-UNICEF indicators OT - nutritional assessment OT - public health COIS- There are no conflicts of interest. EDAT- 2026/05/13 06:31 MHDA- 2026/05/13 06:32 PMCR- 2026/03/01 CRDT- 2026/05/13 04:46 PHST- 2024/08/25 00:00 [received] PHST- 2025/12/20 00:00 [accepted] PHST- 2026/05/13 06:32 [medline] PHST- 2026/05/13 06:31 [pubmed] PHST- 2026/05/13 04:46 [entrez] PHST- 2026/03/01 00:00 [pmc-release] AID - IJCM-51-419 [pii] AID - 10.4103/ijcm.ijcm_610_24 [doi] PST - ppublish SO - Indian J Community Med. 2026 Mar-Apr;51(2):419-422. doi: 10.4103/ijcm.ijcm_610_24. Epub 2026 Mar 26. PMID- 42125007 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260513 LR - 20260813 IS - 3005-7590 (Electronic) IS - 3005-7590 (Linking) VI - 3 IP - 5 DP - 2026 May TI - The use of urinary lateral-flow lipoarabinomannan assays for TB diagnosis in children. PG - 327-334 LID - 10.5588/ijtldopen.25.0667 [doi] AB - BACKGROUND: Detection of lipoarabinomannan (LAM) in urine is a promising non-sputum-based test for TB. We aimed to evaluate Fujifilm SILVAMP TB-LAM (FujiLAM) for the diagnosis of TB in children, using AlereLAM as a comparator. METHODS: Between January 2019 to July 2021, children and young adolescents with presumptive TB disease were enrolled in five countries as part of the RaPaed-TB study. Standardised microbiological, radiologic, and clinical data were used to define TB category following published consensus criteria. FujiLAM and AlereLAM were performed on a single urine sample at enrolment. RESULTS: Of 975 children enrolled, 818 (83.9%) had FujiLAM results available. Median age was 5.5 years (interquartile range 2.4-9.4), 83 (10.1%) had severe acute malnutrition, and 138 (16.9%) were living with HIV. Using a microbiological reference standard, overall sensitivity of FujiLAM was 31.0% (95% confidence interval [CI]: 24.7-37.9) and that of AlereLAM 13.3% (95% CI: 9.0-18.8), whereas the overall specificity was 89.8% (95% CI: 86.3-92.7) and 92.7% (95% CI: 89.6-95.1), respectively. Marked differences in FujiLAM accuracy were noted between production lots. CONCLUSION: FujiLAM remains a promising non-invasive, urine-based biomarker for childhood TB diagnosis. However, the observed lot-to-lot variability underscores the need for improved assays with rigorous multi-lot evaluations to ensure reliability in future studies. CI - (c) 2026 The Authors. FAU - Sabi, I AU - Sabi I AD - Mbeya Medical Research Centre, National Institute for Medical Research, Mbeya, Tanzania. AD - Department of Paediatrics and Child Health, School of Medicine and Dentistry, University of Dodoma, Dodoma, Tanzania. FAU - Olbrich, L AU - Olbrich L AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, Ludwig Maximilian University of Munich, Munich, Germany. AD - Fraunhofer Institute for Translational Medicine and Pharmacology, Immunology, Infection and Pandemic Research, Munich, Germany. AD - German Centre for Infection Research (DZIF), Partner Site Munich, Munich, Germany. FAU - Olomi, W AU - Olomi W AD - Mbeya Medical Research Centre, National Institute for Medical Research, Mbeya, Tanzania. FAU - Mfinanga, A AU - Mfinanga A AD - Mbeya Medical Research Centre, National Institute for Medical Research, Mbeya, Tanzania. FAU - Zar, H J AU - Zar HJ AD - Department of Paediatrics and Child Health, SA-MRC Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa. FAU - Nicol, M P AU - Nicol MP AD - Marshall Centre, School of Biomedical Sciences, University of Western Australia, Perth, WA, Australia. FAU - Franckling-Smith, Z AU - Franckling-Smith Z AD - Department of Paediatrics and Child Health, SA-MRC Unit on Child and Adolescent Health, University of Cape Town, Cape Town, South Africa. FAU - Khosa, C AU - Khosa C AD - Instituto Nacional de Saude (INS), Marracuene, Mozambique. AD - Department of Physiological Science, Clinical Pharmacology, Faculty of Medicine, Eduardo Mondlane University, Maputo, Mozambique. AD - Departments of Clinical Science and International Public Health, Liverpool School of Tropical Medicine, Liverpool, UK. FAU - Banze, D AU - Banze D AD - Instituto Nacional de Saude (INS), Marracuene, Mozambique. FAU - Nliwasa, M AU - Nliwasa M AD - TB/HIV Research Group, College of Medicine, Blantyre, Malawi. FAU - Corbett, E L AU - Corbett EL AD - TB/HIV Research Group, College of Medicine, Blantyre, Malawi. AD - TB Centre, London School of Hygiene and Tropical Medicine, London, UK. FAU - Semphere, R AU - Semphere R AD - TB/HIV Research Group, College of Medicine, Blantyre, Malawi. FAU - Verghese, V P AU - Verghese VP AD - Pediatric Infectious Diseases, Department of Pediatrics, Christian Medical College (CMC), Vellore, India. FAU - Michael, J S AU - Michael JS AD - Department of Clinical Microbiology, Christian Medical College (CMC), Vellore, India. FAU - Larsson, L AU - Larsson L AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, Ludwig Maximilian University of Munich, Munich, Germany. FAU - Graham, S M AU - Graham SM AD - University of Melbourne Department of Paediatrics and Murdoch Children's Research Institute, Royal Children's Hospital, Melbourne, VIC, Australia. FAU - Song, R AU - Song R AD - Oxford Vaccine Group, Department of Paediatrics and National Institute for Health and Care Research Oxford Biomedical Research Centre, University of Oxford, Oxford, UK. FAU - Nabeta, P AU - Nabeta P AD - FIND (Foundation for Innovative New Diagnostics), Geneva, Switzerland. FAU - Trollip, A AU - Trollip A AD - FIND (Foundation for Innovative New Diagnostics), Geneva, Switzerland. FAU - Hoelscher, M AU - Hoelscher M AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, Ludwig Maximilian University of Munich, Munich, Germany. AD - Fraunhofer Institute for Translational Medicine and Pharmacology, Immunology, Infection and Pandemic Research, Munich, Germany. AD - German Centre for Infection Research (DZIF), Partner Site Munich, Munich, Germany. FAU - Geldmacher, C AU - Geldmacher C AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, Ludwig Maximilian University of Munich, Munich, Germany. AD - German Centre for Infection Research (DZIF), Partner Site Munich, Munich, Germany. FAU - Ntinginya, N E AU - Ntinginya NE AD - Mbeya Medical Research Centre, National Institute for Medical Research, Mbeya, Tanzania. FAU - Heinrich, N AU - Heinrich N AD - Institute of Infectious Diseases and Tropical Medicine, LMU University Hospital, Ludwig Maximilian University of Munich, Munich, Germany. AD - Fraunhofer Institute for Translational Medicine and Pharmacology, Immunology, Infection and Pandemic Research, Munich, Germany. AD - German Centre for Infection Research (DZIF), Partner Site Munich, Munich, Germany. CN - RaPaed-AIDA-TB Consortium LA - eng PT - Journal Article DEP - 20260511 PL - France TA - IJTLD Open JT - IJTLD open JID - 9918803487706676 PMC - PMC13160273 OTO - NOTNLM OT - FujiLAM OT - India OT - LAM OT - Malawi OT - Mozambique OT - South Africa OT - Tanzania OT - paediatric TB OT - tuberculosis COIS- Conflicts of interest: none declared. EDAT- 2026/05/13 06:31 MHDA- 2026/05/13 06:32 PMCR- 2026/05/11 CRDT- 2026/05/13 04:39 PHST- 2025/10/12 00:00 [received] PHST- 2026/02/18 00:00 [accepted] PHST- 2026/05/13 06:32 [medline] PHST- 2026/05/13 06:31 [pubmed] PHST- 2026/05/13 04:39 [entrez] PHST- 2026/05/11 00:00 [pmc-release] AID - 25-0667 [pii] AID - 10.5588/ijtldopen.25.0667 [doi] PST - epublish SO - IJTLD Open. 2026 May 11;3(5):327-334. doi: 10.5588/ijtldopen.25.0667. eCollection 2026 May. PMID- 42124549 OWN - NLM STAT- MEDLINE DCOM- 20260527 LR - 20260529 IS - 1365-2036 (Electronic) IS - 0269-2813 (Linking) VI - 63 IP - 12 DP - 2026 Jun TI - Clinical trial: Efficacy of a Low FODMAP Diet in Paediatric Irritable Bowel Syndrome-A Randomised Crossover Trial With Exploratory Metabolomic Analysis. PG - 1592-1604 LID - 10.1111/apt.70718 [doi] AB - BACKGROUND: Evidence supporting the low fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) diet in paediatric irritable bowel syndrome (IBS) remains limited. Mechanisms underlying inter-individual variability in dietary response in children are poorly understood. AIM: To compare the clinical efficacy of a low FODMAP diet (LFD) versus a dietitian-guided habitual diet (HD; standard FODMAP intake) in children with IBS and to identify faecal and urinary metabolomic signatures associated with treatment response. METHODS: Single-centre, randomised assessor-blinded crossover trial. Children with Rome IV-defined IBS underwent a 2-week run-in, followed by 14 days of LFD or dietitian-guided HD, a 2-week washout, and crossover to the alternate diet. The primary outcome was treatment success (>/= 50% reduction in abdominal pain; period-specific baseline VAS). Secondary outcomes included IBS Severity Scoring System (IBS-SSS), stool pattern, and metabolomic profiling. RESULTS: Sixty-six children (mean age 10.2 years) completed the trial. Treatment success was achieved in 57.6% during LFD versus 30.3% during HD (p = 0.024), with the greatest benefit observed in children with severe baseline pain (VAS > 5). LFD was associated with significant reductions in IBS-SSS scores and bloating. Targeted SCFA analyses showed lower faecal acetic acid during LFD than during HD, while exploratory faecal and urinary volatilome analyses identified candidate features associated with response categories. CONCLUSION: In this randomised crossover trial, a LFD improved abdominal pain and symptom severity in children with IBS, with the greatest benefit in those with severe baseline pain. Exploratory faecal and urinary metabolomic analyses identified candidate features associated with non-response, warranting further validation. TRIAL REGISTRATION: ClinicalTrials.gov identifier: NCT06618677. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Cristofori, Fernanda AU - Cristofori F AD - Interdisciplinary Department of Medicine, Paediatric Section, Children's Hospital' Giovanni XXIII', University of Bari Aldo Moro, Bari, Italy. FAU - Celano, Giuseppe AU - Celano G AD - Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy. FAU - Dargenio, Vanessa Nadia AU - Dargenio VN AD - Interdisciplinary Department of Medicine, Paediatric Section, Children's Hospital' Giovanni XXIII', University of Bari Aldo Moro, Bari, Italy. FAU - Apa, Carmen Aurora AU - Apa CA AUID- ORCID: 0009-0002-4898-9850 AD - Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy. FAU - Amendolara, Monica AU - Amendolara M AD - Ecclesiastical Entity General Regional Hospital Francesco Miulli, Acquaviva Delle Fonti, Italy. FAU - Stella, Maria AU - Stella M AD - Endocrinology-Diabetology Unit, Cittadella della Salute (Health Centre), Lecce Local Health Authority, Lecce, Italy. FAU - Castellaneta, Stefania AU - Castellaneta S AD - Interdisciplinary Department of Medicine, Paediatric Section, Children's Hospital' Giovanni XXIII', University of Bari Aldo Moro, Bari, Italy. FAU - Barone, Michele AU - Barone M AUID- ORCID: 0000-0001-8284-5127 AD - Department of Precision and Regenerative Medicine and Jonian Area, University of Bari Aldo Moro, Bari, Italy. FAU - Vacca, Mirco AU - Vacca M AUID- ORCID: 0000-0003-0813-169X AD - Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy. FAU - De Angelis, Maria AU - De Angelis M AD - Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy. FAU - Francavilla, Ruggiero AU - Francavilla R AD - Interdisciplinary Department of Medicine, Paediatric Section, Children's Hospital' Giovanni XXIII', University of Bari Aldo Moro, Bari, Italy. LA - eng SI - ClinicalTrials.gov/NCT06618677 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260513 PL - England TA - Aliment Pharmacol Ther JT - Alimentary pharmacology & therapeutics JID - 8707234 SB - IM MH - Humans MH - *Irritable Bowel Syndrome/diet therapy/metabolism MH - Cross-Over Studies MH - *FODMAP Diet MH - Female MH - Treatment Outcome MH - Child MH - Metabolomics/methods MH - Feces/chemistry MH - Male MH - Adolescent MH - Abdominal Pain/diet therapy EDAT- 2026/05/13 06:31 MHDA- 2026/05/27 12:36 CRDT- 2026/05/13 04:33 PHST- 2026/04/29 00:00 [revised] PHST- 2026/02/24 00:00 [received] PHST- 2026/05/03 00:00 [accepted] PHST- 2026/05/27 12:36 [medline] PHST- 2026/05/13 06:31 [pubmed] PHST- 2026/05/13 04:33 [entrez] AID - 10.1111/apt.70718 [doi] PST - ppublish SO - Aliment Pharmacol Ther. 2026 Jun;63(12):1592-1604. doi: 10.1111/apt.70718. Epub 2026 May 13. PMID- 42124036 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 9 DP - 2026 Apr 30 TI - From Growth Trajectory to Functional Decline: Age-Contextualized Nutritional Strategies for Muscle Vulnerability. A Narrative Review. LID - 10.3390/nu18091437 [doi] LID - 1437 AB - Muscle vulnerability occurs at both extremes of the human lifespan, although its biological significance differs substantially between developmental growth and late-life decline. During childhood and adolescence, insufficient muscle accretion reflects disruption of physiological anabolic trajectories driven by inadequate energy availability, inflammatory burden, endocrine imbalance, or disease-associated catabolism. In older adults, muscle deterioration is characterized by anabolic resistance, neuromuscular remodeling, chronic low-grade inflammation, and hormonal decline, culminating in sarcopenia and loss of functional independence. The absence of harmonized diagnostic frameworks across age groups limits direct translational extrapolation. A lifespan-informed perspective distinguishing growth-supportive from function-preserving nutritional approaches is, therefore, required. This narrative review examines how major classes of nutritional bioactive interact with molecular pathways regulating skeletal muscle homeostasis in fragile populations across the lifespan. The analysis encompasses energy adequacy, protein quantity and quality, amino acid-dependent anabolic signaling, vitamin D status, lipid-derived mediators, redox-modulating phytochemicals, and micronutrients supporting mitochondrial bioenergetics. In pediatric contexts, nutritional interventions primarily aim to restore anabolic permissiveness within a structurally intact growth environment. In aging individuals, strategies focus on mitigating anabolic resistance through optimized protein intake, correction of micronutrient insufficiencies, and integration with resistance exercise to preserve functional capacity. This narrative review emphasizes the need to distinguish mechanistic rationale from clinically validated interventions, as improvements in molecular pathways do not consistently translate into meaningful functional outcomes. FAU - Malaguarnera, Luisa AU - Malaguarnera L AD - Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy. FAU - Sortino, Vincenzo AU - Sortino V AUID- ORCID: 0000-0002-0188-8430 AD - PhD Program in Innovative Technologies in Biomedical Sciences, University Kore of Enna, 94100 Enna, Italy. AD - National Council of Research, Institute for Research and Biomedical Innovation (IRIB), Unit of Catania, 95123 Catania, Italy. FAU - Surdo, Sofia AU - Surdo S AD - Assotiations ABC OdV Catania, 95027 Catania, Italy. FAU - Piro, Salvatore AU - Piro S AUID- ORCID: 0000-0002-1781-0902 AD - Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy. LA - eng PT - Journal Article PT - Review DEP - 20260430 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Micronutrients) SB - IM MH - Humans MH - *Muscle, Skeletal/growth & development/metabolism/physiology MH - *Aging/physiology MH - *Sarcopenia/prevention & control/physiopathology MH - Child MH - Adolescent MH - Micronutrients MH - Nutritional Status MH - Aged MH - Energy Metabolism MH - Adult PMC - PMC13164821 OTO - NOTNLM OT - age-contextualized nutrition OT - anabolic resistance OT - geriatric sarcopenia OT - impaired muscle accretion OT - inflammaging OT - pediatric growth OT - protein density OT - skeletal muscle COIS- The authors declare no conflict of interest. EDAT- 2026/05/13 06:31 MHDA- 2026/05/13 06:32 PMCR- 2026/04/30 CRDT- 2026/05/13 01:13 PHST- 2026/04/07 00:00 [received] PHST- 2026/04/27 00:00 [revised] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/05/13 06:32 [medline] PHST- 2026/05/13 06:31 [pubmed] PHST- 2026/05/13 01:13 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - nu18091437 [pii] AID - nutrients-18-01437 [pii] AID - 10.3390/nu18091437 [doi] PST - epublish SO - Nutrients. 2026 Apr 30;18(9):1437. doi: 10.3390/nu18091437. PMID- 42124016 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 9 DP - 2026 Apr 29 TI - Dietary and Oral Hygiene Behaviors Associated with Prevalent Caries Status in School-Aged Children of Northern Italy. LID - 10.3390/nu18091416 [doi] LID - 1416 AB - Background/Objectives: Unhealthy dietary behaviors and suboptimal oral hygiene practices remain common among Italian children, potentially affecting both nutritional and oral health. Dental caries, a preventable yet highly prevalent condition in pediatric populations, has a multifactorial etiology in which lifestyle factors play a key role. This study aimed to assess the prevalence of dental caries, dietary habits, and oral hygiene behaviors in school-aged children in Lombardy, and to identify factors associated with prevalent caries status. Methods: A cross-sectional study was conducted on 307 schoolchildren aged 9-10 years from ten schools in Northern Italy. Oral health status was evaluated through the plaque index and the DMFT/dmft index during school-based dental examinations. Dietary habits, lifestyle, and oral hygiene practices were collected through structured questionnaires. A mixed-effects logistic regression model was developed to explore potential associations between variables and prevalent caries status. Results: The dietary patterns, weight status, oral hygiene behaviors, and oral health conditions were generally consistent with the national data. Higher plaque index, skipping breakfast, consuming mid-morning snacks, and parental reports of previous caries experiences were retained in the final model. Internal validation suggested reasonable discriminatory ability overall, whereas calibration shows heterogeneity across schools. Conclusions: The findings highlight suboptimal dietary and oral hygiene behaviors among Lombardy schoolchildren and confirm their association with dental caries. Lifestyle-related factors, particularly oral hygiene practices and eating patterns, showed a relevant association with prevalent caries status in the analyzed sample. These results underscore the need for targeted preventive strategies integrating nutritional education and oral health promotion in pediatric populations. FAU - Troiani, Virginia AU - Troiani V AD - School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy. FAU - Ratti, Edoardo AU - Ratti E AUID- ORCID: 0009-0003-9818-795X AD - School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy. FAU - Gonnella, Daniel AU - Gonnella D AD - School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy. FAU - Panzeri, Maria Cristina AU - Panzeri MC AUID- ORCID: 0009-0000-4663-8542 AD - School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy. FAU - Palestini, Paola AU - Palestini P AUID- ORCID: 0000-0002-1045-8838 AD - School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy. AD - Master's Programme in Applied Food and Nutritional Sciences, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy. FAU - Cazzaniga, Emanuela AU - Cazzaniga E AUID- ORCID: 0000-0002-5006-2280 AD - School of Medicine and Surgery, University of Milano-Bicocca, Via Cadore 48, 20900 Monza, Italy. AD - Master's Programme in Applied Food and Nutritional Sciences, School of Medicine and Surgery, University of Milano-Bicocca, 20900 Monza, Italy. LA - eng PT - Journal Article DEP - 20260429 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Dental Caries/epidemiology MH - Child MH - Italy/epidemiology MH - *Oral Hygiene/statistics & numerical data MH - Female MH - Male MH - Cross-Sectional Studies MH - Prevalence MH - *Feeding Behavior MH - Oral Health MH - *Diet MH - Life Style MH - *Health Behavior PMC - PMC13164890 OTO - NOTNLM OT - children OT - dental caries OT - educational program OT - nutrition OT - oral health OT - prevention COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/05/13 06:31 MHDA- 2026/05/13 06:32 PMCR- 2026/04/29 CRDT- 2026/05/13 01:13 PHST- 2026/03/23 00:00 [received] PHST- 2026/04/23 00:00 [revised] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/05/13 06:32 [medline] PHST- 2026/05/13 06:31 [pubmed] PHST- 2026/05/13 01:13 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - nu18091416 [pii] AID - nutrients-18-01416 [pii] AID - 10.3390/nu18091416 [doi] PST - epublish SO - Nutrients. 2026 Apr 29;18(9):1416. doi: 10.3390/nu18091416. PMID- 42123978 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 9 DP - 2026 Apr 27 TI - Weekday Sleep Duration and Perceived Restorative Sleep, but Not Dietary Intake, Are Associated with Lower Skin Autofluorescence in Japanese Early Adolescent Girls: A Cross-Sectional Study. LID - 10.3390/nu18091377 [doi] LID - 1377 AB - BACKGROUND: Advanced glycation end products (AGEs) accumulate in tissues with age and are associated with the risk of chronic diseases. However, evidence regarding lifestyle factors related to AGE accumulation in healthy adolescents is limited. The aim of this study was to explore dietary and lifestyle factors that may attenuate tissue AGE accumulation, using skin autofluorescence (SAF) as a noninvasive proxy marker, in healthy Japanese early adolescent girls. METHODS: This cross-sectional study included 315 first-year junior high school girls aged 12-13 years from a private school in Japan. SAF was measured on the volar forearm using an AGE Reader MU. Dietary intake was assessed using a validated brief diet history questionnaire (BDHQ-15y). Lifestyle factors, including weekday sleep duration, were assessed using a self-administered questionnaire. Health-related variables (including weight-loss dieting) were also collected. Associations between SAF and each factor were analyzed using generalized linear models and nonparametric tests, with multivariable adjustment for potential confounders. RESULTS: The mean SAF was 1.06 +/- 0.13 arbitrary units. No significant associations were observed between SAF and health-related characteristics, nutrient intakes, or major food-group intakes. Longer weekday sleep duration was significantly associated with lower SAF (p for trend = 0.019) and remained significant after multivariable adjustment (p for trend = 0.018). A similar association was observed for better perceived restorative sleep (p for trend = 0.033; adjusted p for trend = 0.048). CONCLUSIONS: In healthy early adolescent girls, longer weekday sleep duration and better perceived restorative sleep were associated with lower SAF, whereas dietary intake was not. Given the largely irreversible age-related accumulation of AGEs, promoting healthy sleep during adolescence may help attenuate AGE accumulation early in life and reduce long-term AGE-related disease risk. Prospective studies with more detailed dietary assessments are needed to clarify dietary influences and confirm temporality. FAU - Kohri, Toshiyuki AU - Kohri T AD - Department of Clinical Nutrition and Dietetics, Faculty of Clinical Nutrition and Dietetics, Konan Women's University, 6-2-23 Morikita-machi Higashinada-ku, Kobe 658-0001, Japan. FAU - Okamoto, Nozomi AU - Okamoto N AD - Department of School Psychology, Developmental Science and Health Education, Hyogo University of Teacher Education, 942-1 Shimokume, Kato 673-1494, Japan. FAU - Myojin, Chiho AU - Myojin C AD - Department of Food and Nutrition, Faculty of Agriculture, Kindai University, 3327-204 Nakamachi, Nara 631-8505, Japan. FAU - Kawanishi, Masako AU - Kawanishi M AD - Department of Food and Nutrition, Faculty of Agriculture, Kindai University, 3327-204 Nakamachi, Nara 631-8505, Japan. FAU - Makita, Yumika AU - Makita Y AD - Department of Food and Nutrition, Faculty of Agriculture, Kindai University, 3327-204 Nakamachi, Nara 631-8505, Japan. FAU - Yamamoto, Mako AU - Yamamoto M AD - Department of Clinical Nutrition and Dietetics, Faculty of Clinical Nutrition and Dietetics, Konan Women's University, 6-2-23 Morikita-machi Higashinada-ku, Kobe 658-0001, Japan. FAU - Higashine, Yuko AU - Higashine Y AD - Department of Clinical Nutrition and Dietetics, Faculty of Clinical Nutrition and Dietetics, Konan Women's University, 6-2-23 Morikita-machi Higashinada-ku, Kobe 658-0001, Japan. FAU - Nakamoto, Mariko AU - Nakamoto M AUID- ORCID: 0000-0001-7548-7499 AD - Department of Public Health and Applied Nutrition, Institute of Biomedical Sciences, Tokushima University Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan. LA - eng PT - Journal Article DEP - 20260427 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Glycation End Products, Advanced) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Cross-Sectional Studies MH - *Diet MH - *Eating/physiology MH - *Glycation End Products, Advanced/metabolism MH - Japan MH - Life Style MH - Optical Imaging MH - *Skin/metabolism/diagnostic imaging MH - *Sleep/physiology MH - *Sleep Duration MH - Surveys and Questionnaires PMC - PMC13164999 OTO - NOTNLM OT - AGE OT - advanced glycation end product OT - dietary intake OT - early adolescence OT - perceived restorative sleep OT - skin autofluorescence OT - sleep duration COIS- The authors declare no conflicts of interest. EDAT- 2026/05/13 06:31 MHDA- 2026/05/13 06:32 PMCR- 2026/04/27 CRDT- 2026/05/13 01:13 PHST- 2026/03/13 00:00 [received] PHST- 2026/04/18 00:00 [revised] PHST- 2026/04/24 00:00 [accepted] PHST- 2026/05/13 06:32 [medline] PHST- 2026/05/13 06:31 [pubmed] PHST- 2026/05/13 01:13 [entrez] PHST- 2026/04/27 00:00 [pmc-release] AID - nu18091377 [pii] AID - nutrients-18-01377 [pii] AID - 10.3390/nu18091377 [doi] PST - epublish SO - Nutrients. 2026 Apr 27;18(9):1377. doi: 10.3390/nu18091377. PMID- 42123915 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 9 DP - 2026 Apr 22 TI - Pre-Diagnosis Dietary Pattern Differences in Australian Children with Inflammatory Bowel Disease: Exposure Across Ethnicities. LID - 10.3390/nu18091313 [doi] LID - 1313 AB - BACKGROUND/OBJECTIVES: The pre-diagnosis dietary intake in newly diagnosed multi-ethnic paediatric inflammatory bowel disease (PIBD) is not well understood. This study aimed to describe the pre-diagnosis diet and environmental factors in children with newly diagnosed PIBD attending a single Australian tertiary children's hospital. METHODS: A pilot cross-sectional study was conducted from February 2022 to February 2023 involving children with newly diagnosed PIBD. RESULTS: Of 56 children confirmed with PIBD, 54% had Crohn's disease (CD)-mean +/- SD age, 11.55 years +/- 2.84-and 46% had Ulcerative Colitis (UC)-11.50 years +/- 2.94 (45%, non-Caucasian). More Caucasians had an IBD family history (48.3% vs. 20%; p = 0.02 *). Non-Caucasian children demonstrated significantly lower mean serum vitamin D levels than Caucasian children (42.5 vs. 69 nmol/L; p 6 months. Dietary habits were assessed through a Mediterranean diet (MD) adherence validated index: the KIDMED. Associations between BF duration and KIDMED items were assessed using ANOVA, Chi-squared tests, and logistic regression models. RESULTS: Longer BF duration was associated with higher adherence to MD in both surveys. In 2019-2020, mean (SD) KIDMED scores were: no BF 6.5 (2.4), BF6 months 7.0 (2.4), (p<0.001); in 2022-2023, corresponding values were 6.2 (2.4), 6.4 (2.5), and 6.7 (2.4), (p<0.001). Logistic regression analyses showed that in both 2019-2020 and 2022-2023, BF>6 months was associated with lower odds of skipping breakfast and higher odds of consuming cereals at breakfast, vegetables, and rice or pasta. Several associations remained significant after adjustment for exclusive BF and parents' education, employment status, and age, although effect sizes were attenuated. CONCLUSIONS: Longer BF duration was associated with healthier dietary habits and higher adherence to the MD in children and adolescents, but these associations may reflect broader early-life family and socio-educational contexts rather than a direct causal effect of BF itself. CLINICAL TRIAL REGISTRATION: The trial was officially recorded in 2019 with the International Standard Randomized Controlled Trial (ISRCT), bearing the identification number 34,251,612 accessed on 08/08/2019 https//www.isrctn.com/ISRCTN34251612 (21). CI - (c) 2026. The Author(s). FAU - Garcia, Silvia AU - Garcia S AD - Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS, Palma de Mallorca, E-07122, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, Madrid, 28029, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), Palma, Balearic Islands, E-07120, Spain. FAU - Rodenas-Munar, Marina AU - Rodenas-Munar M AD - Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS, Palma de Mallorca, E-07122, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, Madrid, 28029, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), Palma, Balearic Islands, E-07120, Spain. FAU - Carmona-Rosado, Luis AU - Carmona-Rosado L AD - Public Health and Epidemiology Research Group, School of Medicine and Health Sciences, Universidad de Alcala, Alcala de Henares, Madrid, 28871, Spain. FAU - Sevilla-Sanchez, Marta AU - Sevilla-Sanchez M AD - Faculty of Sports Sciences and Physical Education, Universidade da Coruna, A Coruna, Spain. FAU - Gusi, Narcis AU - Gusi N AD - Physical Activity and Quality of Life Research Group (AFYCAV), Faculty of Sport Sciences, University of Extremadura, Caceres, Spain. AD - Instituto de Investigacion e Innovacion en el Deporte (INIDE), Caceres, 10003, Spain. FAU - Gomez, Santiago F AU - Gomez SF AD - Gasol Foundation Europe, Sant Boi de Llobregat, Barcelona, 08830, Spain. AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. AD - Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Research Institute, Barcelona, Spain. AD - Nursing and Physiotherapy Department, University of Lleida, Lleida, Spain. FAU - Gonzalez-Gross, Marcela AU - Gonzalez-Gross M AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, Madrid, 28029, Spain. AD - ImFINE Research Group, Department of Health and Human Performance, Universidad Politecnica de Madrid, Madrid, Spain. FAU - Warnberg, Julia AU - Warnberg J AD - EpiPHAAN Research Group, Faculty of Health Sciences, Universidad de Malaga - Instituto de Investigacion Biomedica de Malaga (IBIMA Bionand), Malaga, Spain. FAU - Aznar, Susana AU - Aznar S AD - PAFS Research Group, Faculty of Sports Sciences, University of Castilla-La Mancha- Toledo Campus, Toledo, Spain. FAU - Pulgar, Susana AU - Pulgar S AD - Regional Unit of Sports Medicine of Principado de Asturias, Fundacion Deportiva Municipal de Aviles, Aviles, Spain. FAU - Serra-Majem, Lluis AU - Serra-Majem L AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, Madrid, 28029, Spain. AD - Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas, Spain. AD - Preventive Medicine Service, Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health Service, Las Palmas, Spain. FAU - Martin-Oliveros, Adela AU - Martin-Oliveros A AD - Sociedad Espanola de Farmacia Clinica, Familiar y Comunitaria (SEFAC), Madrid, Spain. FAU - Marin-Cascales, Elena AU - Marin-Cascales E AD - UCAM Research Center for High Performance Sport, Universidad Catolica de Murcia, Murcia, 30107, Spain. AD - Faculty of Sport, Universidad Catolica de Murcia, Murcia, 30107, Spain. FAU - Fito, Montse AU - Fito M AD - Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Institute for Medical Research, Barcelona, 08003, Spain. FAU - Diez, Julia AU - Diez J AD - Public Health and Epidemiology Research Group, School of Medicine and Health Sciences, Universidad de Alcala, Alcala de Henares, Madrid, 28871, Spain. FAU - Gonzalez-Valeiro, Miguel Angel AU - Gonzalez-Valeiro MA AD - Faculty of Sports Sciences and Physical Education, Universidade da Coruna, A Coruna, Spain. FAU - Gomez, Jesus Sanchez AU - Gomez JS AD - Physical Activity and Quality of Life Research Group (AFYCAV), Faculty of Sport Sciences, University of Extremadura, Caceres, Spain. AD - Instituto de Investigacion e Innovacion en el Deporte (INIDE), Caceres, 10003, Spain. FAU - Berruezo, Paula AU - Berruezo P AD - Public Health and Epidemiology Research Group, School of Medicine and Health Sciences, Universidad de Alcala, Alcala de Henares, Madrid, 28871, Spain. AD - Gasol Foundation Europe, Sant Boi de Llobregat, Barcelona, 08830, Spain. FAU - Zapico, Augusto G AU - Zapico AG AD - ImFINE Research Group, Department of Health and Human Performance, Universidad Politecnica de Madrid, Madrid, Spain. FAU - Oostrom-Rodriguez, Alvaro AU - Oostrom-Rodriguez A AD - EpiPHAAN Research Group, Faculty of Health Sciences, Universidad de Malaga - Instituto de Investigacion Biomedica de Malaga (IBIMA Bionand), Malaga, Spain. FAU - Martin-Moraleda, Evelyn AU - Martin-Moraleda E AD - PAFS Research Group, Faculty of Sports Sciences, University of Castilla-La Mancha- Toledo Campus, Toledo, Spain. FAU - Herrera-Ramos, Estefania AU - Herrera-Ramos E AD - Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas, Spain. FAU - Mateos-Lardies, Ana AU - Mateos-Lardies A AD - Sociedad Espanola de Farmacia Clinica, Familiar y Comunitaria (SEFAC), Madrid, Spain. FAU - Alcaraz, Pedro E AU - Alcaraz PE AD - UCAM Research Center for High Performance Sport, Universidad Catolica de Murcia, Murcia, 30107, Spain. AD - Faculty of Sport, Universidad Catolica de Murcia, Murcia, 30107, Spain. FAU - Schroder, Helmut AU - Schroder H AD - Gasol Foundation Europe, Sant Boi de Llobregat, Barcelona, 08830, Spain. AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. AD - Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Institute for Medical Research, Barcelona, 08003, Spain. FAU - Labayen, Idoia AU - Labayen I AD - ELIKOS Group, Department of Health Sciences, Institute for Sustainability and Food Chain Innovation (IS-FOOD), Public University of Navarre, Pamplona, Spain. FAU - Bouzas, Cristina AU - Bouzas C AD - Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS, Palma de Mallorca, E-07122, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, Madrid, 28029, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), Palma, Balearic Islands, E-07120, Spain. FAU - Tur, Josep A AU - Tur JA AD - Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS, Palma de Mallorca, E-07122, Spain. pep.tur@uib.es. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, Madrid, 28029, Spain. pep.tur@uib.es. AD - Health Research Institute of Balearic Islands (IdISBa), Palma, Balearic Islands, E-07120, Spain. pep.tur@uib.es. AD - Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, IDISBA & CIBEROBN, Guillem Colom Bldg, Campus, Palma de Mallorca, E-07122, Spain. pep.tur@uib.es. LA - eng GR - N/A/Fundacion PROBITAS/ GR - N/A/Gasol Foundation/ GR - N/A/FC Barcelona Foundation/ GR - N/A/Banco Santander/ GR - N/A/IFA/ GR - N/A/Vienna/ GR - N/A/Fundacion Deporte Joven/ GR - N/A/European Regional Development Fund/ GR - CIBEROBN CB12/03/30038 and CIBERESP CB22/03/00058/Instituto de Salud Carlos III/ GR - FOLIUM, PRIMUS, SYNERGIA and LIBERI/IDISBA Grants/ GR - RED2022-134800-T/Ministerio de Ciencias e Innovacion, Spain/ PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260512 PL - England TA - Int Breastfeed J JT - International breastfeeding journal JID - 101251562 SB - IM MH - Humans MH - Female MH - Child MH - Adolescent MH - Cross-Sectional Studies MH - *Breast Feeding/statistics & numerical data MH - Male MH - *Feeding Behavior MH - Diet, Mediterranean/statistics & numerical data MH - Time Factors MH - Surveys and Questionnaires PMC - PMC13340382 OTO - NOTNLM OT - Adolescents OT - Breastfeeding OT - Children OT - Dietary habits OT - Mediterranean diet OT - PASOS study COIS- Declarations. Institutional review board statement: The PASOS study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Ethics Committee of the Fundacio Sant Joan de Deu, Barcelona, Spain (ref. PIC 179 - 18; 17 December 2018). Informed consent: A signed informed consent form was obtained from the parent or legal guardian of each participant. Competing interests: The authors declare no competing interests. EDAT- 2026/05/13 06:31 MHDA- 2026/07/07 12:34 PMCR- 2026/05/12 CRDT- 2026/05/13 00:16 PHST- 2026/02/11 00:00 [received] PHST- 2026/05/05 00:00 [accepted] PHST- 2026/07/07 12:34 [medline] PHST- 2026/05/13 06:31 [pubmed] PHST- 2026/05/13 00:16 [entrez] PHST- 2026/05/12 00:00 [pmc-release] AID - 10.1186/s13006-026-00851-8 [pii] AID - 851 [pii] AID - 10.1186/s13006-026-00851-8 [doi] PST - epublish SO - Int Breastfeed J. 2026 May 12;21(1):66. doi: 10.1186/s13006-026-00851-8. PMID- 42120340 OWN - NLM STAT- Publisher LR - 20260601 IS - 1475-2662 (Electronic) IS - 0007-1145 (Linking) DP - 2026 May 13 TI - Mean corpuscular Hb and red cell distribution width for early screening of non-anaemic Fe deficiency in children: a retrospective study. PG - 1-8 LID - 10.1017/S0007114526107168 [doi] AB - Fe deficiency (ID) is a common nutritional disorder, especially among children and women of reproductive age. Detecting ID before it progresses to Fe deficiency anaemia (IDA) is critical for prevention. This study assessed mean corpuscular Hb (MCH) and red cell distribution width (RDW) as complete blood count (CBC) based markers for early non-anaemic Fe deficiency (NAID). We retrospectively analysed records of children aged 2 months to 6 years who underwent regular general health checks at Fujian Provincial Maternal and Child Health Hospital between July 2022 and July 2024. ID was defined by serum ferritin < 15 microg/l. Children with thalassemia, inflammatory conditions (C-reactive protein > 5 mg/l) or incomplete data were excluded. Logistic regression was used to evaluate associations between CBC indices and ID. Model discrimination was assessed by the area under the receiver operating characteristic curve and externally validated using National Health and Nutrition Examination Survey (August 2021-August 2023, Cycle 12) data. A total of 2018 children were included (training: n 1413, testing: n 605; external validation: n 232). MCH (OR = 0.63; 95 % CI, 0.52, 0.76; P < 0.001) and RDW (OR = 1.44; 95 % CI, 1.16, 1.79; P = 0.001) were independent predictors of ID. The model showed consistent performance, with AUC of 0.77 (training), 0.81 (testing) and 0.87 (validation). MCH and RDW are practical markers for early NAID detection in Chinese and US children, offering a valuable tool for any setting with an automated haematology analyser, particularly when access to advanced Fe studies is restricted. FAU - Guo, Chong AU - Guo C AD - College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical Universityhttps://ror.org/050s6ns64, Fuzhou, Fujian, People's Republic of China. FAU - Zhou, Fei AU - Zhou F AD - College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical Universityhttps://ror.org/050s6ns64, Fuzhou, Fujian, People's Republic of China. FAU - Qu, Zhi AU - Qu Z AUID- ORCID: 0000-0003-0578-939X AD - Institute for Epidemiology, Social Medicine and Health System, Hannover Medical School, Hannover30625, Germany. FAU - Ma, Mei AU - Ma M AD - College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical Universityhttps://ror.org/050s6ns64, Fuzhou, Fujian, People's Republic of China. FAU - Qiu, Jun AU - Qiu J AD - College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical Universityhttps://ror.org/050s6ns64, Fuzhou, Fujian, People's Republic of China. FAU - Ge, Pin AU - Ge P AD - College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical Universityhttps://ror.org/050s6ns64, Fuzhou, Fujian, People's Republic of China. FAU - Guo, Jingmin AU - Guo J AD - College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Maternity and Child Health Hospital, Fujian Medical Universityhttps://ror.org/050s6ns64, Fuzhou, Fujian, People's Republic of China. LA - eng PT - Journal Article DEP - 20260513 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM OTO - NOTNLM OT - Complete blood count OT - Fe deficiency OT - Mean corpuscular Hb OT - Non-anaemic Fe deficiency OT - Red cell distribution width EDAT- 2026/05/13 00:28 MHDA- 2026/05/13 00:28 CRDT- 2026/05/12 22:53 PHST- 2026/05/13 00:28 [pubmed] PHST- 2026/05/13 00:28 [medline] PHST- 2026/05/12 22:53 [entrez] AID - S0007114526107168 [pii] AID - 10.1017/S0007114526107168 [doi] PST - aheadofprint SO - Br J Nutr. 2026 May 13:1-8. doi: 10.1017/S0007114526107168. PMID- 42119870 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1879-0003 (Electronic) IS - 0141-8130 (Linking) VI - 366 DP - 2026 Jun TI - Salecan improves diet-induced obesity and hepatic steatosis by regulating citrate cycle intermediates. PG - 152496 LID - S0141-8130(26)02423-2 [pii] LID - 10.1016/j.ijbiomac.2026.152496 [doi] AB - Salecan, a naturally occurring beta-glucan, represents an approved novel food ingredient in China. Although its numerous health benefits are acknowledged, the underlying mechanisms addressing obesity and hepatic steatosis remain uncertain. This investigation integrated a mouse model of diet-induced obesity with clinical observations in obese children to investigate the effects and underlying mechanisms of Salecan. In the animal model, obese mice were administered Salecan by gavage for 8 weeks. Salecan significantly promoted weight loss, reduced blood glucose levels, and improved insulin resistance in obese mice. It also reduced food intake without altering systemic energy metabolism, as evidenced by unchanged overall energy expenditure and maintained substrate utilization patterns. Notably, Salecan suppressed adipocyte hypertrophy within white adipose tissue and mitigated hepatic lipid accumulation. Metabolomic analysis revealed that Salecan markedly altered the serum metabolic profile of obese mice, particularly by elevating the levels of citrate cycle cycle intermediates, including alpha-ketoglutarate (AKG), fumarate, and malate. In the clinical component, serum AKG levels were significantly lower in obese children relative to healthy controls. They exhibited inverse correlations with body mass index, abdominal circumference, and triglyceride levels. The findings validate that Salecan mediates anti-obesity effects by regulating the citrate cycle in murine models, thereby strengthening its potential as a nutritional intervention for obesity and hepatic steatosis. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Liu, Kerong AU - Liu K AD - Department of Endocrinology, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, China. FAU - Chen, Sha AU - Chen S AD - Nanjing Medical University, Wuxi Medical Center, Wuxi, China. FAU - Cao, Minkai AU - Cao M AD - Department of Obstetrics and Gynecology, Affiliated Women's Hospital of Jiangnan University, Wuxi Maternity and Child Health Care Hospital, Wuxi, Jiangsu, China. FAU - Xu, Xu AU - Xu X AD - Department of Endocrinology, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, China. FAU - Jiang, Li AU - Jiang L AD - Department of Endocrinology, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, China. FAU - Liu, Zhenzhen AU - Liu Z AD - Department of Endocrinology, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, China. FAU - Lai, Jinxin AU - Lai J AD - Department of Medical Laboratory, Wuxi Eighth People's Hospital, Wuxi, China. FAU - Pan, Xiaoxiao AU - Pan X AD - Clinical Medical College, Jinzhou Medical University, The first People's hospital of Lianyungang, Lianyungang, Jiangsu, China. FAU - Zhang, Yu AU - Zhang Y AD - School of Food Science and Technology, Jiangnan University, Wuxi, China. FAU - Xu, Lulian AU - Xu L AD - Department of Endocrinology, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, China. Electronic address: xllgzw@126.com. FAU - Zhang, Le AU - Zhang L AD - Department of Neonatology, Affiliated Children's Hospital of Jiangnan University, Wuxi Children's Hospital, Wuxi, Jiangsu, China. Electronic address: zhangle@jiangnan.edu.cn. FAU - Gu, Ying AU - Gu Y AD - Department of Obstetrics and Gynecology, Affiliated Wuxi Maternity and Child Health Care Hospital of Nanjing Medical University, Wuxi, China. Electronic address: 13861870460@163.com. LA - eng PT - Journal Article DEP - 20260511 PL - Netherlands TA - Int J Biol Macromol JT - International journal of biological macromolecules JID - 7909578 RN - 0 (beta-Glucans) RN - 0 (salecan) SB - IM MH - Animals MH - *Obesity/drug therapy/metabolism/etiology/blood MH - Mice MH - *Fatty Liver/drug therapy/metabolism/etiology MH - *beta-Glucans/pharmacology/therapeutic use MH - Male MH - Humans MH - *Citric Acid Cycle/drug effects MH - Energy Metabolism/drug effects MH - Diet, High-Fat/adverse effects MH - Liver/drug effects/metabolism/pathology MH - Insulin Resistance MH - Disease Models, Animal MH - Mice, Inbred C57BL MH - Lipid Metabolism/drug effects OTO - NOTNLM OT - Citrate cycle OT - Hepatic steatosis OT - Obesity OT - Salecan OT - alpha-ketoglutarate COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/13 00:29 MHDA- 2026/05/29 15:44 CRDT- 2026/05/12 19:23 PHST- 2025/05/21 00:00 [received] PHST- 2026/01/10 00:00 [revised] PHST- 2026/05/10 00:00 [accepted] PHST- 2026/05/29 15:44 [medline] PHST- 2026/05/13 00:29 [pubmed] PHST- 2026/05/12 19:23 [entrez] AID - S0141-8130(26)02423-2 [pii] AID - 10.1016/j.ijbiomac.2026.152496 [doi] PST - ppublish SO - Int J Biol Macromol. 2026 Jun;366:152496. doi: 10.1016/j.ijbiomac.2026.152496. Epub 2026 May 11. PMID- 42119424 OWN - NLM STAT- MEDLINE DCOM- 20260603 LR - 20260605 IS - 1873-7072 (Electronic) IS - 0308-8146 (Linking) VI - 518 DP - 2026 Jul 30 TI - In-vitro digestion assessment of DIAAR, protein digestibility, and ACE/COX inhibitory activity of solid-state fermented beans. PG - 149582 LID - S0308-8146(26)01740-1 [pii] LID - 10.1016/j.foodchem.2026.149582 [doi] AB - Adequate protein intake is critical during childhood to support growth, development, and immune function. This in vitro study evaluated the effect of solid-state fermentation with Pleurotus ostreatus on protein digestibility, amino acid profile, and bioactivity (ACE and COX inhibition) in two local bean varieties. Fermentation enhanced gastric-phase protein digestibility; however, only Roget beans showed a notable increase after intestinal stage (67% in fermented vs. 57% autoclaved samples, representing a 17.5% relative increase). Additionally, bioaccessible amino acid profile improved significantly in fermented Roget beans, with increases in hydrophobic and aromatic amino acids. Correspondingly, DIAAR values for lysine, valine, and isoleucine rose, while sulfur amino acids decreased, whereas Herradura beans showed limited or negative changes. Fermentation preserved COX-2 inhibition while reducing COX-1 activity. Overall, fermented Roget beans showed enhanced digestion and functional properties, suggesting nutritional benefits for consumers of local legume-based foods, particularly in child-oriented formulations, pending in vivo validation. CI - Copyright (c) 2024. Published by Elsevier Ltd. FAU - Munoz-Pina, Sara AU - Munoz-Pina S AD - University Institute of Food Engineering - FoodUPV. Universitat Politecnica de Valencia. Camino de Vera s/n, 46022, Valencia, Spain. Electronic address: samuopi@upvnet.upv.es. FAU - Khvostenko, Kateryna AU - Khvostenko K AD - University Institute of Food Engineering - FoodUPV. Universitat Politecnica de Valencia. Camino de Vera s/n, 46022, Valencia, Spain. FAU - Garcia-Hernandez, Jorge AU - Garcia-Hernandez J AD - Applied Microbiology Advanced Research Centre (CAMA) - UPV, Universitat Politecnica de Valencia, Camino de Vera s/n, 46022, Valencia, Spain. FAU - Heredia, Ana AU - Heredia A AD - University Institute of Food Engineering - FoodUPV. Universitat Politecnica de Valencia. Camino de Vera s/n, 46022, Valencia, Spain. FAU - Andres, Ana AU - Andres A AD - University Institute of Food Engineering - FoodUPV. Universitat Politecnica de Valencia. Camino de Vera s/n, 46022, Valencia, Spain. LA - eng PT - Journal Article DEP - 20260511 PL - England TA - Food Chem JT - Food chemistry JID - 7702639 RN - 0 (Amino Acids) RN - 0 (Angiotensin-Converting Enzyme Inhibitors) RN - 0 (Cyclooxygenase Inhibitors) SB - IM MH - Humans MH - Amino Acids/metabolism/chemistry MH - *Angiotensin-Converting Enzyme Inhibitors/metabolism/chemistry/analysis MH - *Cyclooxygenase Inhibitors/metabolism/chemistry/analysis MH - Digestion MH - *Fabaceae/chemistry/metabolism/microbiology MH - Fermentation MH - *Food, Processed MH - Models, Biological MH - *Pleurotus/metabolism MH - Seeds/chemistry/metabolism OTO - NOTNLM OT - Anti-hypertensive activity OT - Anti-inflammatory activity OT - Beans OT - Digestibility in vitro DIAAS OT - Fermentation OT - Pleurotus Ostreatus OT - Total amino acids COIS- Declaration of competing interest The authors have no affiliation with any organization with a direct or indirect financial interest in the subject matter discussed in the manuscript. EDAT- 2026/05/13 00:29 MHDA- 2026/06/03 06:35 CRDT- 2026/05/12 18:20 PHST- 2025/11/11 00:00 [received] PHST- 2026/04/20 00:00 [revised] PHST- 2026/05/09 00:00 [accepted] PHST- 2026/06/03 06:35 [medline] PHST- 2026/05/13 00:29 [pubmed] PHST- 2026/05/12 18:20 [entrez] AID - S0308-8146(26)01740-1 [pii] AID - 10.1016/j.foodchem.2026.149582 [doi] PST - ppublish SO - Food Chem. 2026 Jul 30;518:149582. doi: 10.1016/j.foodchem.2026.149582. Epub 2026 May 11. PMID- 42119087 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20261007 IS - 1879-8365 (Electronic) IS - 0926-9630 (Linking) VI - 335 DP - 2026 May 7 TI - Development of an Exergaming-Intervention for Children and Adolescents During Hemodialysis: A Pilot Study. PG - 34-39 LID - 10.3233/SHTI260051 [doi] AB - BACKGROUND: Children and adolescents with chronic kidney failure undergoing hemodialysis are frequently physically inactive. Intradialytic exergaming may provide a motivating approach; however, it has not yet been evaluated in pediatric dialysis settings. METHODS: Intervention development was guided by requirements from nurses, physicians, psychologists, and evidence from the literature. Six exergaming devices (hardware) and six game applications (software) were screened. Following structured evaluation, the ICAROS games and their control principle were identified as promising, while the available hardware was not suitable for the target group. Therefore, the ICAROS Seated Trainer (I.S.T.) was developed in an iterative process and tested in a pilot phase. RESULTS: Nine children (11.6 s 3.8 years) participated twice weekly for 20 minutes over 8 weeks. The intervention was well accepted by participants and nursing staff. No relevant medical adverse events and no motivational dropouts occurred. DISCUSSION: These findings provide initial evidence for feasibility and high acceptability of intradialytic exergaming using the I.S.T.. FAU - Kerstin, Marleen AU - Kerstin M AD - German Sport University Cologne, Institute of Cardiology and Sports Medicine, Cologne, Germany. FAU - Stegelmann, Lene AU - Stegelmann L AD - German Sport University Cologne, Institute of Cardiology and Sports Medicine, Cologne, Germany. FAU - Schalk, Gesa AU - Schalk G AD - Bonn Center of Pediatric Nephrology, Bonn, Germany. FAU - Hoppe, Bernd AU - Hoppe B AD - Bonn Center of Pediatric Nephrology, Bonn, Germany. FAU - Peer, Oliver AU - Peer O AD - Nephrokids Nordrhein-Westfalen e.V., Cologne, Germany. FAU - Klein, Luisa AU - Klein L AD - Pediatric Nephrology, University Hospital of Cologne, Germany. FAU - Taylan, Christina AU - Taylan C AD - Pediatric Nephrology, University Hospital of Cologne, Germany. FAU - Brixius, Klara AU - Brixius K AD - German Sport University Cologne, Institute of Cardiology and Sports Medicine, Cologne, Germany. FAU - Schmidt, Thomas AU - Schmidt T AD - German Sport University Cologne, Institute of Cardiology and Sports Medicine, Cologne, Germany. AD - Schuchtermann-Klinik Bad Rothenfelde, Bad Rothenfelde, Germany. LA - eng PT - Journal Article PL - Netherlands TA - Stud Health Technol Inform JT - Studies in health technology and informatics JID - 9214582 SB - IM MH - Humans MH - Pilot Projects MH - Child MH - *Renal Dialysis/methods MH - Adolescent MH - *Video Games MH - Female MH - *Exercise Therapy/methods/instrumentation MH - Male MH - *Kidney Failure, Chronic/therapy/psychology MH - Treatment Outcome OTO - NOTNLM OT - Adolescent OT - Child OT - Exercise therapy OT - Exergaming OT - Hemodialysis EDAT- 2026/05/12 18:35 MHDA- 2026/05/12 18:36 CRDT- 2026/05/12 16:32 PHST- 2026/05/12 18:36 [medline] PHST- 2026/05/12 18:35 [pubmed] PHST- 2026/05/12 16:32 [entrez] AID - SHTI260051 [pii] AID - 10.3233/SHTI260051 [doi] PST - ppublish SO - Stud Health Technol Inform. 2026 May 7;335:34-39. doi: 10.3233/SHTI260051. PMID- 42118079 OWN - NLM STAT- MEDLINE DCOM- 20260907 LR - 20260907 IS - 1878-2620 (Electronic) IS - 1499-4046 (Linking) VI - 58 IP - 9 DP - 2026 Sep TI - Exploring Perceptions and Practices Toward Sustainable Diets Among College Students in Lebanon. PG - 883-891 LID - S1499-4046(26)00093-X [pii] LID - 10.1016/j.jneb.2026.03.014 [doi] AB - OBJECTIVE: To assess college students' knowledge, attitudes, and practices (KAP) toward sustainable diets and their potential relationship with food security status, and to explore the associations between the KAP variables, adjusting for socioeconomic correlates. METHODS: A cross-sectional online survey was conducted among a convenience sample of 701 university students in Lebanon. The KAP of sustainable diets was assessed using previously validated tools and served as dependent variables, with socioeconomic characteristics, including food security status, as independent variables in multiple stepwise logistic regression models. RESULTS: Majority of students exhibited poor knowledge of sustainable diets (71.7%) and unsustainable practices (75.7%), whereas attitudes were predominantly positive (89.3%). Regression models showed that higher knowledge scores, not attitudes, were significantly associated with sustainable practices (P < 0.001). Other correlates of KAP included female sex, university major, financial aid, and food security status, among others (all P-values < 0.05). CONCLUSIONS AND IMPLICATIONS: This study can help inform educational strategies, public health programs, and food policies promoting sustainable diets among young adults. CI - Copyright (c) 2026 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved. FAU - Saade, Elyssa AU - Saade E AD - Food Security Program, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon. FAU - Kharroubi, Samer AU - Kharroubi S AD - Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon. FAU - Nasreddine, Lara AU - Nasreddine L AD - Department of Nutrition and Food Sciences, Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon. FAU - Zurayk, Rami AU - Zurayk R AD - Landscape Design and Ecosystem Management Department, Maroun Semaan Faculty of Engineering and Architecture, American University of Beirut, Beirut, Lebanon. FAU - Jomaa, Lamis AU - Jomaa L AD - Department of Nutrition, Gillings School of Global Public Health, the University of North Carolina at Chapel Hill, North Carolina, NC; Faculty of Agricultural and Food Sciences, American University of Beirut, Beirut, Lebanon. Electronic address: lamisj@unc.edu. LA - eng PT - Journal Article DEP - 20260512 PL - United States TA - J Nutr Educ Behav JT - Journal of nutrition education and behavior JID - 101132622 SB - IM MH - Humans MH - Lebanon MH - Female MH - *Students/statistics & numerical data/psychology MH - *Health Knowledge, Attitudes, Practice MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - Universities MH - Adult MH - Adolescent MH - *Diet/statistics & numerical data MH - Surveys and Questionnaires OTO - NOTNLM OT - college students OT - knowledge, attitudes, practices OT - sustainable diets COIS- CONFLICT OF INTEREST DISCLOSURE The authors have not stated any conflicts of interest. EDAT- 2026/05/12 12:35 MHDA- 2026/09/07 23:34 CRDT- 2026/05/12 10:27 PHST- 2025/07/10 00:00 [received] PHST- 2026/03/25 00:00 [revised] PHST- 2026/03/28 00:00 [accepted] PHST- 2026/09/07 23:34 [medline] PHST- 2026/05/12 12:35 [pubmed] PHST- 2026/05/12 10:27 [entrez] AID - S1499-4046(26)00093-X [pii] AID - 10.1016/j.jneb.2026.03.014 [doi] PST - ppublish SO - J Nutr Educ Behav. 2026 Sep;58(9):883-891. doi: 10.1016/j.jneb.2026.03.014. Epub 2026 May 12. PMID- 42117563 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260819 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) VI - 5 IP - 5 DP - 2026 May 12 TI - Pharmacological treatments for Friedreich ataxia. PG - CD007791 LID - 10.1002/14651858.CD007791.pub5 [doi] LID - CD007791 AB - RATIONALE: Friedreich ataxia (FRDA) is a rare inherited autosomal recessive neurological disorder, characterised initially by unsteadiness in standing and walking, and slowly progressing to wheelchair dependency, usually in the late teens or early twenties. Scoliosis, pes cavus and cardiomyopathy are often present at diagnosis. As the disease progresses, individuals usually develop slurred speech, auditory impairment (especially in a noisy environment), urinary tract morbidity, diabetes, anxiety, depression, muscle spasticity and visual disturbances. Cardiac abnormalities cause premature death in 60% of people with FRDA. There is no easily defined clinical or biochemical marker to assess progression and no known curative treatment. This is the third update of a review published in 2009 and updated in 2012 and 2016. OBJECTIVES: To assess the effects of pharmacological treatments for people with Friedreich ataxia (FRDA) after 12 months of treatment. SEARCH METHODS: To identify studies for inclusion in this review, we searched CENTRAL, MEDLINE, Embase, CINAHL Plus, TRIP, Orphanet, WHO International Clinical Trials Registry Platform (ICTRP) and ClinicalTrials.gov. We also checked reference lists of relevant studies and contacted study authors. The most recent search was on 4 February 2025. ELIGIBILITY CRITERIA: We were interested in randomised controlled trials (RCTs) and quasi-RCTs of pharmacological treatments (including vitamins) in people with genetically-confirmed FRDA. To be included in the review, studies had to last at least 12 months. OUTCOMES: We assessed the following outcomes after 12 months of treatment: change in score on a validated ataxia rating scale; change in interventricular septal thickness in diastole (IVSTd) by cardiac magnetic resonance imaging or echocardiogram; change in activities of daily living (ADL) using a validated questionnaire; change in upper limb dexterity; and change in cardiopulmonary exercise testing (CPET). We also assessed treatment-related adverse events with medication continued for the study period, and treatment-emergent adverse events leading to cessation of medication or death during the study period. RISK OF BIAS: Using the Cochrane risk of bias tool RoB 2, we assessed the risk of bias in the seven outcomes reported in our summary of findings tables. SYNTHESIS METHODS: We synthesised the results of the studies for each outcome using meta-analysis, where possible. We calculated the mean difference (MD) or standardised mean difference (SMD) for continuous outcomes, and the risk ratio (RR) for dichotomous outcomes, all with 95% confidence intervals (CIs). We used GRADE to assess the certainty of evidence for our prespecified outcomes as high, moderate, low or very low. INCLUDED STUDIES: We included eight RCTs in this updated review. We included seven of them in meta-analysis, and these studies enroled a total of 574 participants, with sample sizes ranging from 29 to 232 participants per study. One study was international, with centres in North America, Europe and Australia. There were four other multicentre studies (three in Europe and one in North America). Single-centre studies were conducted in the UK, Italy and France. Participants in the studies ranged from eight to 70 years of age at enrolment, with the mean age in each study being between 18 years and 35 years (with an unweighted pooled mean age across studies of 25.9 years). All of the studies enroled both males and females, with the proportion of female participants ranging from 21% to 58%. Sixty-eight per cent of participants had severe ataxia, while the other 32% had moderate ataxia. The studies tested epoetin alpha, CoQ10 and vitamin E, idebenone, leriglitazone, omaveloxolone, and RT001. One study tested pioglitazone but has not published any results. Four of the studies were pharmaceutical-industry-controlled. SYNTHESIS OF RESULTS: Meta-analysis of seven studies demonstrated that pharmacological treatment probably makes little or no difference to scores on the ataxia rating scale after 12 months of treatment (SMD 0.02, 95% CI -0.23 to 0.26; I(2) = 42%; 7 studies, 513 participants; moderate-certainty evidence). The evidence was very uncertain about the effects of treatment on IVSTd (MD -0.51, 95% CI -1.10 to 0.09; I(2) = 80%; 2 studies, 72 participants; very low-certainty evidence) and on ADL (MD -0.59, 95% CI -1.39 to 0.21; I(2) = 24%; 3 studies, 167 participants; very low-certainty evidence). Meta-analysis of three studies showed that treatment probably improves upper limb dexterity (SMD -0.42, 95% CI -0.73 to -0.11; I(2) = 0%; 3 studies, 166 participants; moderate-certainty evidence). We are very uncertain about the effect of pharmacological treatment on CPET (SMD -0.16, 95% CI -0.46 to 0.13; I(2) = 0%; 3 studies, 181 participants; very low-certainty evidence). We are very uncertain whether pharmacological treatment has any effect on treatment-related adverse events (RR 0.88, 95% CI 0.63 to 1.22; I(2) = 0%; 2 studies, 104 participants; very low-certainty evidence). There were only 104 participants in this analysis out of a total of 545 participants, so the result may have little relevance. Meta-analysis of six studies found that there may be little to no difference between pharmacological treatment and placebo in treatment-emergent adverse events leading to cessation of medication or death (RR 1.24, 95% CI 0.44 to 3.48; I(2) = 0%; 6 studies, 313 participants; low-certainty evidence). Our certainty in the evidence ranged from very low to moderate. We downgraded all outcomes by one or two levels for imprecision, with further downgrades for inconsistency (for the outcomes of IVSTd, ADL, CPET) and suspected publication bias (for the outcomes of IVSTd, ADL, CPET and adverse events). AUTHORS' CONCLUSIONS: In this updated Cochrane systematic review, meta-analysis of results on the ataxia rating scale showed that pharmacological treatments probably make little or no difference compared with placebo after 12 months of treatment. Given this result, the probable improvement that we found in upper limb dexterity was unexpected. Treatment-emergent adverse events leading to cessation of medication or death may be no more common in treatment groups than placebo groups as there were few adverse events detected in the treated groups. However, the studies may not have detected all rare and serious adverse events. FUNDING: The authors in this review received no funding. REGISTRATION: Protocol (2009) DOI: 10.1002/14651858.CD007791 Original review (2009) DOI: 10.1002/14651858.CD99791.pub2 Update (2012) DOI: 10.1002/14651858.CD007791.pub3 Update (2016) DOI: 10.1002/14651858.CD007791.pub4. CI - Copyright (c) 2026 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. FAU - Lyons, Shane AU - Lyons S AD - Department of Neurology, University Hospital Waterford, Waterford, Ireland. FAU - Kearney, Mary AU - Kearney M AUID- ORCID: 0009-0002-4915-285X AD - Department of Neurology, National Ataxia Centre, Tallaght University Hospital, Dublin, Ireland. AD - General Practitioner, Irish College of General Practitioners, Dublin, Ireland. FAU - Fahey, Michael C AU - Fahey MC AD - Department of Paediatrics, Monash University, Clayton, Australia. FAU - Janjal, Prashant AU - Janjal P AD - Adjunct Professor, Department of Conservative Dentistry and Endodontics, Saveetha Institute of Medical and Technical Sciences, Chennai, India. FAU - Pandolfo, Massimo AU - Pandolfo M AD - Department of Neurology and Neurosurgery, Lakeshore Hospital, Co-Director, Clinical Research Unit (CRU) The Neuro (Montreal Neurological Institute/Hospital), McGill University, Montreal, Canada. FAU - Patton, Patricia AU - Patton P AD - Research, Policy & Information Department, Irish College of General Practitioners, Dublin, Ireland. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260512 PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 RN - 1339-63-5 (Ubiquinone) RN - HB6PN45W4J (idebenone) RN - 0 (Pyridones) RN - 2BTY8KH53L (Deferiprone) SB - IM UOF - Cochrane Database Syst Rev. 2016 Aug 30;(8):CD007791. doi: 10.1002/14651858.CD007791.pub4. PMID: 27572719 MH - Humans MH - *Friedreich Ataxia/drug therapy MH - Randomized Controlled Trials as Topic MH - Ubiquinone/therapeutic use/analogs & derivatives MH - Pyridones/therapeutic use MH - Deferiprone PMC - PMC13162314 COIS- Shane Lyons: none known Mary Kearney: MK attended a Biogen Advisory Board meeting. Prashant Janjal: none known Michael Fahey: MF sees people with FRDA in a private clinic. Massimo Pandolfo: MP is the owner of a patent on the molecular diagnosis of Friedreich ataxia. He was involved in two industry-controlled studies in this review. He was not involved in evaluating either of these studies in the review process. Patricia Patton: none known EDAT- 2026/05/12 12:36 MHDA- 2026/05/12 12:37 PMCR- 2027/05/12 CRDT- 2026/05/12 08:12 PHST- 2026/05/12 12:37 [medline] PHST- 2026/05/12 12:36 [pubmed] PHST- 2026/05/12 08:12 [entrez] PHST- 2027/05/12 00:00 [pmc-release] AID - CD007791.pub5 [pii] AID - 10.1002/14651858.CD007791.pub5 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2026 May 12;5(5):CD007791. doi: 10.1002/14651858.CD007791.pub5. PMID- 42117476 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1758-8111 (Electronic) IS - 1758-8103 (Linking) VI - 16 IP - 3 DP - 2026 Jun TI - Prediction of Cardiovascular Risk Using Machine Learning Based on Maximal Oxygen Consumption, Physical Fitness, and Anthropometry. PG - e70081 LID - 10.1111/cob.70081 [doi] AB - Cardiovascular risk factors in adolescence, often persist into adulthood, with low cardiorespiratory fitness representing one of the strongest predictors of future cardiovascular disease. We aimed to classify cardiovascular risk associated with low cardiorespiratory fitness in adolescents using machine learning models based on anthropometric and muscular fitness variables. A cross-sectional dataset of 7,852 adolescents aged 13-16 years was analysed. Predictors included body mass index, waist circumference, waist-to-height ratio, standing long jump, push-ups, and sit-ups, while the binary outcome was cardiovascular risk derived from maximal oxygen consumption (VO(2) (max)) cut-points. Data were standardised, class imbalance was addressed using Synthetic Minority Over-sampling TEchnique (SMOTE), and eight supervised classifiers were trained with stratified five-fold cross-validation and grid search. Ensemble tree-based methods outperformed kernel-based models. Gradient Boosting achieved the best balance between predictive performance (area under the curve-receiver operating curve [AUC-ROC] 0.716, F1-score 0.857, recall 0.760, accuracy 0.755), followed by Random Forest. SHapley Additive exPlanations (SHAP) analyses indicated that muscular fitness measures, particularly push-ups, sit-ups and standing long jump, contributed most to risk classification, whereas anthropometric indicators showed lower importance. These findings suggest that machine learning models built from school-based muscular fitness tests and basic anthropometry can discriminate adolescents at cardiovascular risk due to low cardiorespiratory fitness, offering a feasible, low-cost strategy to support early identification and targeted physical activity interventions. CI - (c) 2026 World Obesity Federation. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AUID- ORCID: 0000-0002-9311-6576 AD - Faculty Education and Humanities, Universidad Andres Bello, Vina del Mar, Chile. FAU - Olivares, Rodrigo AU - Olivares R AD - Escuela de Ingenieria Informatica, Universidad de Valparaiso, Valparaiso, Chile. FAU - Guzman-Munoz, Eduardo AU - Guzman-Munoz E AD - Escuela de Kinesiologia, Facultad de Salud, Universidad Santo Tomas, Talca, Chile. AD - Escuela de Pedagogia en Educacion Fisica, Facultad de Educacion, Universidad Autonoma de Chile, Talca, Chile. FAU - Concha-Cisternas, Yeny AU - Concha-Cisternas Y AD - Escuela de Kinesiologia, Facultad de Salud, Universidad Santo Tomas, Talca, Chile. AD - Vicerrectoria de Investigacion e Innovacion, Universidad Arturo Prat, Iquique, Chile. FAU - de Souza-Lima, Josivaldo AU - de Souza-Lima J AD - Faculty Education and Humanities, Universidad Andres Bello, Vina del Mar, Chile. FAU - Garcia-Carrillo, Exal AU - Garcia-Carrillo E AUID- ORCID: 0000-0001-6190-938X AD - Department of Physical Activity Sciences, Faculty of Education Sciences, Universidad Catolica del Maule, Talca, Chile. AD - School of Education, Faculty of Human Sciences, Universidad Bernardo O'Higgins, Santiago, Chile. FAU - Paez-Herrera, Jacqueline AU - Paez-Herrera J AD - Grupo eFidac, Escuela de Educacion Fisica, Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile. FAU - Rojas-Valverde, Daniel AU - Rojas-Valverde D AD - Centro de Investigacion, Desarrollo e Innovacion en Salud y Deporte (CIDISAD), Escuela Ciencias del Movimiento Humano y Calidad e Vida (CIEMHCAVI), Universidad Nacional, Oriente, Costa Rica. FAU - Cortes-Roco, Guillermo AU - Cortes-Roco G AD - Facultad de Ciencias de la Vida, Universidad Vina del Mar, Vina del Mar, Chile. FAU - Clemente-Suarez, Vicente AU - Clemente-Suarez V AD - Grupo de Investigacion en Cultura, Educacion y Sociedad, Universidad de la Costa, Barranquilla, Colombia. AD - Universidad Europea de Madrid, Faculty of Sports Sciences, Tajo Street s/n, Madrid, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AUID- ORCID: 0000-0002-7412-7624 AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Ecuador. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno, Chile. LA - eng PT - Journal Article PL - England TA - Clin Obes JT - Clinical obesity JID - 101560587 SB - IM MH - Humans MH - Adolescent MH - *Oxygen Consumption/physiology MH - *Physical Fitness/physiology MH - *Machine Learning MH - *Cardiovascular Diseases MH - Cross-Sectional Studies MH - Female MH - Heart Disease Risk Factors MH - Male MH - *Cardiorespiratory Fitness/physiology MH - Predictive Learning Models MH - *Anthropometry MH - Body Mass Index MH - Classification Algorithms MH - Prediction Algorithms MH - Random Forest MH - Waist Circumference MH - Risk Factors MH - Boosting Machine Learning Algorithms OTO - NOTNLM OT - cardiovascular diseases OT - exercise OT - machine learning OT - physical fitness EDAT- 2026/05/12 12:36 MHDA- 2026/05/12 12:37 CRDT- 2026/05/12 07:12 PHST- 2025/12/29 00:00 [revised] PHST- 2025/11/19 00:00 [received] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/05/12 12:37 [medline] PHST- 2026/05/12 12:36 [pubmed] PHST- 2026/05/12 07:12 [entrez] AID - 10.1111/cob.70081 [doi] PST - ppublish SO - Clin Obes. 2026 Jun;16(3):e70081. doi: 10.1111/cob.70081. PMID- 42116681 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260917 IS - 1945-7189 (Electronic) IS - 0163-769X (Print) IS - 0163-769X (Linking) VI - 47 IP - 5 DP - 2026 Sep 16 TI - Epigenetics and childhood obesity: DNA methylation coordinates environment and gene regulation. PG - 608-636 LID - 10.1210/endrev/bnag013 [doi] AB - Childhood obesity is a complex disorder which results from the combined contribution of genetics, the environment, and development, which is programmed and coordinated by epigenetic mechanisms. Of them, DNA methylation has emerged as an important molecular interface between environmental inputs and changes in gene expression. In this review, we provide an overview of the role of DNA methylation in childhood obesity during the key developmental stages, from prenatal life and childhood to adolescence. We also highlight the available evidence from candidate genes and genome-wide association studies implicating critical loci involved in energy homeostasis and adipogenesis, where DNA methylation is altered. Further, we also provide an overview of how maternal obesity, nutritional status, and bariatric surgery shape offspring's methylation profiles and contribute to the increased risk of programming obesity across generations. Although aberrant methylation patterns are consistently associated with altered metabolic phenotypes, disentangling causality remains a significant challenge. Herein, we highlight emerging approaches, such as rigorous longitudinal cohorts, epigenetic Mendelian randomization, and CRISPR-based epigenome editing, that are beginning to provide the analytical clarity needed to move beyond association. Finally, we examine the potential of DNA methylation signatures to inform early risk stratification and prevention possibilities. Although yet to be clinically validated, whole-genome methylation profiling is increasingly integrated with systems biology and multi-omics frameworks, making the identification of robust, clinically actionable markers more promising. A more precise understanding of how epigenetic processes shape susceptibility to childhood obesity could ultimately support strategies capable of altering lifelong metabolic trajectories. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Endocrine Society. FAU - Kaimala, Suneesh AU - Kaimala S AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi 15551, United Arab Emirates. FAU - Leow, Melvin Khee-Shing AU - Leow MK AD - Institute for Human Development and Potential (IHDP), Agency for Science, Technology and Research (A*STAR), 30 Medical Drive, Singapore 117609, Republic of Singapore. AD - Singapore Institute of Food and Biotechnology Innovation, A*STAR, Singapore 138634, Republic of Singapore. AD - Department of Endocrinology, Tan Tock Seng Hospital, Singapore 308433, Republic of Singapore. AD - Cardiovascular and Metabolic Diseases Program, Duke-NUS Medical School, Singapore 169857, Republic of Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Republic of Singapore. FAU - Ansari, Suraiya Anjum AU - Ansari SA AD - Department of Biochemistry and Molecular Biology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi 15551, United Arab Emirates. AD - Zayed Center for Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi 15551, United Arab Emirates. AD - ASPIRE Precision Medicine, Research Institute Abu Dhabi, Al Ain, Abu Dhabi 15551, United Arab Emirates. FAU - Emerald, Bright Starling AU - Emerald BS AUID- ORCID: 0000-0001-6875-2258 AD - Department of Anatomy, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi 15551, United Arab Emirates. AD - Zayed Center for Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi 15551, United Arab Emirates. AD - ASPIRE Precision Medicine, Research Institute Abu Dhabi, Al Ain, Abu Dhabi 15551, United Arab Emirates. LA - eng GR - #12R110/United Arab Emirates University/ GR - #12R206/United Arab Emirates University/ GR - #12R365/United Arab Emirates University/ GR - Zayed Bin Sultan Charitable and Humanitarian Foundation/ GR - Abu Dhabi's Advanced Technology Research Council/ GR - ASPIRE Precision Medicine Research Institute/ PT - Journal Article PT - Review PL - United States TA - Endocr Rev JT - Endocrine reviews JID - 8006258 SB - IM MH - Humans MH - *DNA Methylation MH - *Epigenesis, Genetic MH - *Pediatric Obesity/genetics MH - Child MH - Developmental Origins of Health and Disease MH - Female MH - *Gene Expression Regulation MH - Animals PMC - PMC13577769 OTO - NOTNLM OT - DNA methylation OT - childhood obesity OT - early environment OT - epigenetic regulation OT - gene expression EDAT- 2026/05/12 06:33 MHDA- 2026/09/16 03:34 PMCR- 2026/05/11 CRDT- 2026/05/12 02:13 PHST- 2025/12/30 00:00 [received] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/09/16 03:34 [medline] PHST- 2026/05/12 06:33 [pubmed] PHST- 2026/05/12 02:13 [entrez] PHST- 2026/05/11 00:00 [pmc-release] AID - 8676198 [pii] AID - bnag013 [pii] AID - 10.1210/endrev/bnag013 [doi] PST - ppublish SO - Endocr Rev. 2026 Sep 16;47(5):608-636. doi: 10.1210/endrev/bnag013. PMID- 42116676 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2046-4924 (Electronic) IS - 1366-5278 (Print) IS - 1366-5278 (Linking) VI - 30 IP - 36 DP - 2026 May TI - Olanzapine for young people with anorexia nervosa: a synopsis of the main results from the OPEN open-label feasibility study. PG - 1-17 LID - 10.3310/GJHH0812 [doi] AB - BACKGROUND: In clinical practice, olanzapine is commonly used in young people with anorexia nervosa, although the underpinning evidence-base is limited. However, its efficacy, tolerability, acceptability and adherence rate, and the patients', carers' and clinicians' views of olanzapine treatment are unclear. This synopsis article summarises the methods and results of the OPEN feasibility study, overarching the findings and drawing comprehensive conclusions from a quantitative feasibility outcome paper and two qualitative research papers. METHODS: The OPEN study assessed the feasibility of a future randomised controlled trial on olanzapine in young people with anorexia nervosa in an open-label, one-armed feasibility study. In this study, we aimed to include 55 patients with anorexia nervosa or atypical anorexia nervosa aged 12-24 who gained < 2 kg within at least 1 month of treatment as usual. Time points for assessments were at baseline, 8 weeks, 16 weeks, and 6 or 12 months. We estimated recruitment, adherence and attrition rates and mean changes in body weight, body mass index and eating disorder psychopathology. In addition, we explored the views on and experiences with olanzapine treatment within a clinical trial setting using qualitative interviews with young people with anorexia nervosa, their families and clinicians. RESULTS: Fifty-two people were pre-screened, 35 were eligible and 20 participants were recruited and started olanzapine. Of these, 15 continued olanzapine for >/= 16 weeks. Participants experienced, on average, a decrease in their eating disorder psychopathology, and body weight and body mass index increased during treatment with olanzapine as an adjunct to treatment as usual. Important themes derived from semi-structured qualitative interviews with young people and their parents were: moving away from the illness towards recovery, evaluating information on olanzapine, consent and trust in shared decision-making and the ambivalence around recovery. The main themes expressed by clinicians included: acknowledging the concerns of young people with anorexia nervosa and their families, prioritising person-centred care, the limited service capacity and strict study eligibility criteria. LIMITATIONS: The study failed to meet the recruitment target and showed low adherence rates for treatment with olanzapine. Possible reasons for the recruitment difficulties and the low adherence rate include the high clinical workload of eating disorder services during and after the COVID-19 pandemic, the heterogeneity of eating disorder service setup across the country, and the reluctance of patients to agree to take olanzapine under the relatively restricted conditions of a clinical study. CONCLUSIONS: A realistic time schedule for site-preparation, recruitment, treatment and follow-up, realistic recruitment targets and easy access to medical and laboratory examinations may improve the success of future feasibility studies and randomised controlled trials in this patient group. FUTURE WORK: The difficulties in conducting the OPEN study will inform the planning for future pharmacological and non-pharmacological studies in anorexia nervosa. Therefore, we developed a checklist with action points for the planning of pharmacological trials in eating disorders. Furthermore, novel pharmacological options such as typical and atypical psychedelic drugs (e.g. psilocybin and ketamine) might be more acceptable for people with anorexia nervosa as they do not have the side effect of immediate weight gain. FUNDING: This synopsis presents independent research funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme as award number NIHR130780. FAU - Filiz, Ece Sengun AU - Filiz ES AUID- ORCID: 0000-0002-8779-3351 AD - Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK. FAU - Stringer, Dominic AU - Stringer D AUID- ORCID: 0000-0001-5624-1733 AD - King's Clinical Trials Unit, King's College London, London, UK. AD - Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Kellermann, Vanessa AU - Kellermann V AUID- ORCID: 0009-0004-5969-3769 AD - Department of Health Service and Population Research, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Olive, Rachel Rowan AU - Olive RR AUID- ORCID: 0000-0002-0871-9859 AD - Department of Health Service and Population Research, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Said, Olena AU - Said O AUID- ORCID: 0000-0003-1090-839X AD - King's Clinical Trials Unit, King's College London, London, UK. AD - Centre for Research in Eating and Weight Disorders (CREW), Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Mutwalli, Hiba AU - Mutwalli H AUID- ORCID: 0000-0001-9267-6283 AD - Centre for Research in Eating and Weight Disorders (CREW), Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. AD - Department of Clinical Nutrition, College of Applied Medical Sciences, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. FAU - Bektas, Sevgi AU - Bektas S AUID- ORCID: 0000-0002-0613-5032 AD - Centre for Research in Eating and Weight Disorders (CREW), Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. AD - Department of Psychology, Hacettepe University, Ankara, Turkiye. FAU - Akkese, Melahat Nur AU - Akkese MN AUID- ORCID: 0009-0009-2866-4849 AD - Centre for Research in Eating and Weight Disorders (CREW), Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Ireland, Katie AU - Ireland K AUID- ORCID: 0009-0001-2772-0628 AD - South London and Maudsley NHS Foundation Trust, London, UK. FAU - Beishon-Murley, Demelza AU - Beishon-Murley D AUID- ORCID: 0000-0002-0987-3890 AD - South West London and St George's Mental Health NHS Trust, London, UK. FAU - Khor, Joel W T AU - Khor JWT AUID- ORCID: 0000-0001-7860-6131 AD - South West London and St George's Mental Health NHS Trust, London, UK. FAU - Allman, Lee AU - Allman L AUID- ORCID: 0009-0002-9890-0236 AD - Sussex Partnership NHS Foundation Trust, Hampshire, UK. AD - Hampshire and Isle of Wight Healthcare NHS Foundation Trust, Winchester, UK. FAU - Kotze, Nicus AU - Kotze N AUID- ORCID: 0009-0000-5430-5086 AD - Dorset Healthcare University NHS Foundation Trust, Poole, UK. FAU - Carter, Ben AU - Carter B AUID- ORCID: 0000-0003-0318-8865 AD - King's Clinical Trials Unit, King's College London, London, UK. AD - Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Tyrrell-Bunge, Elizabeth AU - Tyrrell-Bunge E AUID- ORCID: 0009-0006-5112-3811 AD - South London and Maudsley NHS Foundation Trust, London, UK. FAU - Rowlands, Katie AU - Rowlands K AUID- ORCID: 0000-0002-9671-4344 AD - Centre for Research in Eating and Weight Disorders (CREW), Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Keeler, Johanna Louise AU - Keeler JL AUID- ORCID: 0000-0002-3905-9857 AD - Centre for Research in Eating and Weight Disorders (CREW), Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Ivin, Glynis AU - Ivin G AUID- ORCID: 0009-0004-3599-1315 AD - South London and Maudsley NHS Foundation Trust, London, UK. FAU - Simic, Mima AU - Simic M AUID- ORCID: 0000-0003-4900-1429 AD - South London and Maudsley NHS Foundation Trust, London, UK. FAU - Sually, Dilveer Singh AU - Sually DS AUID- ORCID: 0000-0002-4112-6502 AD - Centre for Research in Eating and Weight Disorders (CREW), Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Bentley, Jessica AU - Bentley J AUID- ORCID: 0000-0003-2991-4757 AD - Centre for Research in Eating and Weight Disorders (CREW), Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Young, Allan H AU - Young AH AUID- ORCID: 0000-0003-2291-6952 AD - Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK. AD - Centre for Research in Eating and Weight Disorders (CREW), Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. AD - South London and Maudsley NHS Foundation Trust, London, UK. FAU - Madden, Sloane AU - Madden S AUID- ORCID: 0000-0001-5903-6647 AD - The University of Sydney, Sydney, NSW, Australia. FAU - Byford, Sarah AU - Byford S AUID- ORCID: 0000-0001-7084-1495 AD - Department of Health Service and Population Research, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Landau, Sabine AU - Landau S AUID- ORCID: 0000-0002-3615-8075 AD - King's Clinical Trials Unit, King's College London, London, UK. AD - Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Treasure, Janet AU - Treasure J AUID- ORCID: 0000-0003-0871-4596 AD - Centre for Research in Eating and Weight Disorders (CREW), Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. AD - South London and Maudsley NHS Foundation Trust, London, UK. FAU - Schmidt, Ulrike AU - Schmidt U AUID- ORCID: 0000-0003-1335-1937 AD - Centre for Research in Eating and Weight Disorders (CREW), Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. AD - South London and Maudsley NHS Foundation Trust, London, UK. FAU - Nicholls, Dasha AU - Nicholls D AUID- ORCID: 0000-0001-7257-6605 AD - Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK. FAU - Lawrence, Vanessa AU - Lawrence V AUID- ORCID: 0000-0001-7852-2018 AD - Department of Health Service and Population Research, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Himmerich, Hubertus AU - Himmerich H AUID- ORCID: 0000-0003-1209-6073 AD - Centre for Research in Eating and Weight Disorders (CREW), Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. AD - South London and Maudsley NHS Foundation Trust, London, UK. LA - eng PT - Journal Article PL - England TA - Health Technol Assess JT - Health technology assessment (Winchester, England) JID - 9706284 RN - N7U69T4SZR (Olanzapine) RN - 0 (Antipsychotic Agents) RN - 12794-10-4 (Benzodiazepines) SB - IM MH - Humans MH - *Anorexia Nervosa/drug therapy MH - *Olanzapine/therapeutic use MH - Adolescent MH - Feasibility Studies MH - Female MH - *Antipsychotic Agents/therapeutic use/adverse effects MH - Young Adult MH - Child MH - Male MH - Benzodiazepines/therapeutic use PMC - PMC13181506 OAB - Better treatments are needed for severely underweight young people (age 12-24) with anorexia who do not respond to the standard psychotherapies to support their physical and psychological recovery. Many doctors prescribe olanzapine, because olanzapine has been reported to help with weight gain. However, it has not been approved for treating anorexia yet, because it is unclear whether it is helpful and whether it is safe to be used for young people. Before this study, we did not know what proportion of young people with anorexia would consider olanzapine in addition to usual treatment or participate in a study assessing this. We also wanted to know how long patients might be willing to take it. We had hoped to include 55 patients with anorexia aged 12-24 years into a study testing olanzapine. We documented how many patients agreed to participate and receive olanzapine alongside their usual treatment. For adolescent patients, their parents or guardians also needed to consent. We used questionnaires, physical examinations and laboratory investigations. We examined patients before they started olanzapine, after 8 and 16 weeks, and after 6 and 12 months. However, we were only able to identify 52 potential patients for study. Of these, 35 would have been suitable, but only 20 participants chose to start olanzapine. Of these, 15 continued olanzapine for 16 weeks or longer. Participants experienced, on average, a beneficial effect on their psychological symptoms and some weight gain. Patients and their parents expressed the importance of moving away from the illness and towards recovery, getting accurate in-depth information about olanzapine, and being actively involved in treatment decisions. Clinicians highlighted the importance of acknowledging the concerns of young people with anorexia and their families and providing person-centred care. Staff shortages and other challenges for eating disorder services during and after the COVID-19 pandemic and the strict criteria for entering the study may have been the main reasons for why we were unable to recruit 55 patients with anorexia into this study. OABL- eng OTO - NOTNLM OT - ADHERENCE OT - ANOREXIA NERVOSA OT - ATTRITION OT - FEASIBILITY OT - OLANZAPINE OT - RECRUITMENT OT - SIDE EFFECTS EDAT- 2026/05/12 06:34 MHDA- 2026/05/12 06:35 PMCR- 2026/05/18 CRDT- 2026/05/12 02:13 PHST- 2026/05/12 06:35 [medline] PHST- 2026/05/12 06:34 [pubmed] PHST- 2026/05/12 02:13 [entrez] PHST- 2026/05/18 00:00 [pmc-release] AID - 10.3310/GJHH0812 [doi] PST - ppublish SO - Health Technol Assess. 2026 May;30(36):1-17. doi: 10.3310/GJHH0812. PMID- 42116062 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 May 11 TI - Criterion validity of a self-reported web-based data collection tool to measure daily school travel in middle school children. LID - 10.1186/s12889-026-27628-2 [doi] LID - 1517 AB - BACKGROUND: Various interventions have been developed with the intention to increase the amount of physical activity among children, including those promoting active school travel (AST). However, no gold standard currently exists for measuring different travel modes in AST. This study evaluates the criterion validity of a web-based data collection tool designed for children to self-report their school travel. PURPOSE: To assess the criterion validity of a web-based data collection tool for daily self-registration of commuting mode, time, and distance among middle school children in Sweden. METHODS: Thirty children (10-12 years old) from six schools in Falun, Sweden, were recruited using snowball sampling. The children self-reported their school travel data for one day, including travel mode, commuting time, and distance. Their reports were compared to a criterion standard based on direct observations. Spearman correlation and the Wilcoxon signed-rank test were used to analyze the accuracy of the self-reported data. RESULT: The web-based data collection tool demonstrated 100% agreement between self-reported and observed travel modes, with high correlations for commuting time and distance (r(s)=0.953-0.989, p < 0.001). The Wilcoxon signed rank test showed no significant differences between self-reported data and criterion standard (p = 0.243-0.903). CONCLUSION: The strong agreement between self-reported and observed travel data indicates high criterion validity, suggesting that the web-based data collection tool is a reliable method for middle school children to self-report their daily school travel. CI - (c) 2026. The Author(s). FAU - Andersson, Mathias AU - Andersson M AD - Department of Medical Sciences, School of Health and Welfare, Dalarna University, Falun, Sweden. maae@du.se. FAU - Tseli, Elena AU - Tseli E AD - Department of Medical Sciences, School of Health and Welfare, Dalarna University, Falun, Sweden. AD - Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institutet, Huddinge, Sweden. FAU - Lindqvist, Anna-Karin AU - Lindqvist AK AD - Department of Health, Education and Technology, Lulea University of Technology, Lulea, Sweden. FAU - Palstam, Annie AU - Palstam A AD - Department of Medical Sciences, School of Health and Welfare, Dalarna University, Falun, Sweden. AD - Sahlgrenska Academy, Institute of Neuroscience and Physiology, Department of Clinical Neuroscience, University of Gothenburg, Gothenburg, Sweden. AD - Department of Occupational Therapy and Physiotherapy, Sahlgrenska University Hospital, Gothenburg, Sweden. LA - eng PT - Journal Article PT - Validation Study DEP - 20260511 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Child MH - Sweden MH - *Schools MH - *Internet MH - *Self Report MH - *Transportation/methods/statistics & numerical data MH - Female MH - Reproducibility of Results MH - Male MH - *Data Collection/methods PMC - PMC13159230 OTO - NOTNLM OT - Active school transport OT - Commuting OT - Measurement methods OT - Physical activity OT - Transportation COIS- Declarations. Ethics approval and consent to participate: The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Swedish Ethical Review Authority (Dnr. 2021-03783). During recruitment, it was emphasized that participation was voluntary and could be discontinued without giving reasons. The children received both oral and written information about the study. Written informed consent for participation and publication was obtained from the child and parent/legal guardian prior to participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/12 06:33 MHDA- 2026/05/12 06:34 PMCR- 2026/05/11 CRDT- 2026/05/12 00:38 PHST- 2025/12/16 00:00 [received] PHST- 2026/04/28 00:00 [accepted] PHST- 2026/05/12 06:34 [medline] PHST- 2026/05/12 06:33 [pubmed] PHST- 2026/05/12 00:38 [entrez] PHST- 2026/05/11 00:00 [pmc-release] AID - 10.1186/s12889-026-27628-2 [pii] AID - 27628 [pii] AID - 10.1186/s12889-026-27628-2 [doi] PST - epublish SO - BMC Public Health. 2026 May 11;26(1):1517. doi: 10.1186/s12889-026-27628-2. PMID- 42116057 OWN - NLM STAT- MEDLINE DCOM- 20260823 LR - 20260826 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 May 11 TI - Associations of general and abdominal adiposity with incident elevated blood pressure among Tianjin adolescents: a school-based longitudinal study. LID - 10.1186/s12889-026-27691-9 [doi] LID - 2426 AB - BACKGROUND: Because elevated blood pressure during adolescence often persists into adulthood and increases the risk of cardiovascular diseases, early identification of modifiable risk factors for elevated blood pressure is critical for timely prevention. This study compared the predictive performance of body mass index (BMI) and waist-to-height ratio (WHtR) in identifying incident elevated blood pressure among Tianjin adolescents. METHOD: This longitudinal analysis included 4,694 students aged 11-18 years from the 2023-2024 National Student Common Diseases and Risk Factors Surveillance in Tianjin, China. Modified Poisson regression with false discovery rate (FDR) correction and restricted cubic splines (RCS) were used to assess associations of BMI and WHtR with incident elevated blood pressure, stratified by sex. Predictive performance was evaluated using area under the receiver operating characteristic curves (AUC), integrated discrimination improvement (IDI), calibration plots, and decision curve analysis (DCA). RESULTS: During the one-year interval, 13.2% of girls and 13.5% of boys developed elevated blood pressure. Adjusting for sociodemographic and lifestyle factors, both general and abdominal obesity were significantly associated with incident elevated blood pressure in girls (general obesity: RR 2.25 [95% CI: 1.75-2.88]; abdominal obesity: 1.92 [1.57-2.36]) and boys (general obesity: 2.07 [1.59-2.71]; abdominal obesity: 1.83 [1.48-2.25]). RCS revealed linear associations except for WHtR in girls. AUCs for BMI (girls: 0.640; boys: 0.669) and the combination with WHtR (girls: 0.641; boys: 0.670) were comparable in both sexes; both were similar to WHtR in girls (0.633) but slightly higher than WHtR alone in boys (0.641; DeLong's test p < 0.05). Adding BMI to the basic model improved discrimination more than adding WHtR (IDI: girls 0.0272 vs. 0.0222; boys 0.0242 vs. 0.0179), while including both indices provided no additional improvement. All expanded models showed good calibration and higher net benefits than the basic model, with no additional clinical advantage observed for the combined model. CONCLUSION: Both BMI and WHtR were associated with incident elevated blood pressure and showed comparable discriminative ability. However, BMI provided a greater incremental improvement in risk prediction than WHtR across sexes, with no additional incremental value from combining both indices. CI - (c) 2026. The Author(s). FAU - Feng, Yuqian AU - Feng Y AD - Public Health Research Center, Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. FAU - Sun, Panying AU - Sun P AD - Public Health Research Center, Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. FAU - Zhang, Xianwei AU - Zhang X AD - Institute of Environmental and Public Health, Tianjin Center of Disease Control and Prevention, Tianjin, China. FAU - Zhao, Dan AU - Zhao D AD - Public Health Research Center, Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. FAU - Chu, Yunqi AU - Chu Y AD - Public Health Research Center, Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. FAU - Liu, Zhonghui AU - Liu Z AD - Institute of Environmental and Public Health, Tianjin Center of Disease Control and Prevention, Tianjin, China. FAU - Ferrari, Gerson AU - Ferrari G AD - Escuela de Ciencias de la Actividad Fisica, el Deporte y la Salud, Universidad de Santiago de Chile (USACH), Santiago, Region Metropolitana de Santiago, Chile. AD - Facultad de Ciencias de la Salud, Universidad Autonoma de Chile, Providencia, Chile. FAU - Rezende, Leandro F M AU - Rezende LFM AD - Chronic Disease Epidemiology Research Center, Department of Preventive Medicine, Universidade Federal de Sao Paulo, Sao Paulo, Brazil. AD - Faculty of Health Sciences, Universidad Autonoma de Chile, Providencia, Chile. FAU - Ge, Yuqiu AU - Ge Y AD - Public Health Research Center, Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. FAU - Zhang, Heng AU - Zhang H AD - Department of Child Health Care, Wuxi Maternity and Child Health Care Hospital, Wuxi, Jiangsu, China. FAU - Wu, Yu AU - Wu Y AD - Public Health Research Center, Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. FAU - Wang, Fang AU - Wang F AD - Department of Biostatistics, School of Public Health, Xuzhou Medical University, Xuzhou, Jiangsu, China. fwang@xzhmu.edu.cn. FAU - Wang, Yafeng AU - Wang Y AD - Public Health Research Center, Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. fljfe71518@126.com. AD - Department of Child Health Care, Wuxi Maternity and Child Health Care Hospital, Wuxi, Jiangsu, China. fljfe71518@126.com. LA - eng GR - TJWJ2024QN089/Tianjin Health Research Project/ GR - YXZDXK-3-034C/Tianjin Key Medical Discipline Construction Project/ GR - 72204211/National Natural Science Foundation of China/ GR - JUSRP123076/Fundamental Research Funds for the Central Universities/ PT - Journal Article DEP - 20260511 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Male MH - China/epidemiology MH - Female MH - Longitudinal Studies MH - Adolescent MH - Child MH - Body Mass Index MH - *Hypertension/epidemiology MH - Waist-Height Ratio MH - Risk Factors MH - *Obesity, Abdominal/epidemiology MH - Incidence MH - *Adiposity PMC - PMC13501553 OTO - NOTNLM OT - Adolescents OT - Body mass index OT - Elevated blood pressure OT - Waist-to-height ratio COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki. This study was approved by the Medical Ethics Review Board of Jiangnan University (Approval No. JNU202412RB026) and the Tianjin Center for Disease Control and Prevention (Approval No. TJCDC-R-2023-001). Written informed consent was obtained from all participants and their parents or legal guardians prior to data collection. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/12 06:34 MHDA- 2026/08/24 05:34 PMCR- 2026/05/11 CRDT- 2026/05/12 00:38 PHST- 2025/12/20 00:00 [received] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/08/24 05:34 [medline] PHST- 2026/05/12 06:34 [pubmed] PHST- 2026/05/12 00:38 [entrez] PHST- 2026/05/11 00:00 [pmc-release] AID - 10.1186/s12889-026-27691-9 [pii] AID - 27691 [pii] AID - 10.1186/s12889-026-27691-9 [doi] PST - epublish SO - BMC Public Health. 2026 May 11;26(1):2426. doi: 10.1186/s12889-026-27691-9. PMID- 42115985 OWN - NLM STAT- MEDLINE DCOM- 20260703 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 May 11 TI - Clinimetric evaluation of the 1-minute sit-to-stand test as a functional performance measure associated with quadriceps strength in children with spastic hemiplegic cerebral palsy. LID - 10.1186/s12887-026-06967-4 [doi] LID - 615 AB - PURPOSE: To evaluate the construct validity, test-retest reliability, and clinical applicability of the 1-minute sit-to-stand test (1-MSTST) as a functional performance-based measure associated with quadriceps strength in ambulatory children with spastic hemiplegic cerebral palsy (GMFCS I-II). Despite its validity, instrumented strength assessment is not always feasible in routine pediatric rehabilitation, highlighting the need for simple functional alternatives. METHODS: In this cross-sectional methodological study with a test-retest design, 78 children aged 12-18 years were assessed. Quadriceps strength was measured using hand-held dynamometry. Functional performance was evaluated using the 1-MSTST, and a work score was calculated by multiplying repetitions by body weight. Construct validity was examined through correlations between work score and quadriceps strength. RESULTS: The 1-MSTST work score correlated strongly with affected limb strength (r = 0.72, p < 0.001) and moderately-to-strongly with the unaffected limb (r = 0.65, p < 0.001). Test-retest reliability was good (ICC = 0.78; 95% CI: 0.69-0.85). The standard error of measurement was 92.6 kg.repetitions and the minimal detectable change at the 95% confidence level was 256.7 kg.repetitions. No adverse events occurred. These findings indicate that the 1-MSTST is significantly associated with quadriceps muscle strength and may reflect functional lower limb performance, rather than serving as a direct measure of isolated muscle strength capacity. CONCLUSION: The 1-MSTST is a valid, reliable, and clinically feasible tool for assessing functional performance related to quadriceps strength in ambulatory children with spastic hemiplegic cerebral palsy. It may serve as a practical complementary tool to instrumented strength assessment, particularly in routine and resource-limited clinical settings. CI - (c) 2026. The Author(s). FAU - Baykan, Muge AU - Baykan M AUID- ORCID: 0000-0002-8299-6926 AD - Department of Pediatric Neurology, Recep Tayyip Erdogan University Training and Research Hospital, Rize, Turkey. dr.mugebaykan@gmail.com. FAU - Baykan Copuroglu, Ozge AU - Baykan Copuroglu O AUID- ORCID: 0000-0003-1014-8845 AD - Department of Therapy and Rehabilitation, Incesu Ayse and Saffet Arslan Health Services Vocational School, Kayseri University, Kayseri, Turkey. FAU - Ergun, Betul AU - Ergun B AUID- ORCID: 0000-0001-7212-2937 AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Firat University, Elazig, Turkey. LA - eng PT - Journal Article PT - Validation Study DEP - 20260511 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology/complications MH - Child MH - *Quadriceps Muscle/physiopathology MH - Male MH - Female MH - *Muscle Strength/physiology MH - Cross-Sectional Studies MH - Reproducibility of Results MH - Adolescent MH - *Hemiplegia/physiopathology MH - *Exercise Test/methods MH - Muscle Strength Dynamometer MH - *Physical Functional Performance PMC - PMC13330457 OTO - NOTNLM OT - 1-minute sit-to-stand test OT - Cerebral palsy OT - Pediatric rehabilitation OT - Quadriceps muscle strength OT - Validity and reliability COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the principles of the Declaration of Helsinki. Ethical approval was obtained from the Non-Interventional Research Ethics Committee of Firat University (approval date: 04 September 2025; decision number: 2025/12-20). Written informed consent was obtained from the parents or legal guardians of all participants, and verbal assent was obtained from the children prior to participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/12 06:33 MHDA- 2026/07/03 06:30 PMCR- 2026/05/11 CRDT- 2026/05/12 00:35 PHST- 2026/03/17 00:00 [received] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/07/03 06:30 [medline] PHST- 2026/05/12 06:33 [pubmed] PHST- 2026/05/12 00:35 [entrez] PHST- 2026/05/11 00:00 [pmc-release] AID - 10.1186/s12887-026-06967-4 [pii] AID - 6967 [pii] AID - 10.1186/s12887-026-06967-4 [doi] PST - epublish SO - BMC Pediatr. 2026 May 11;26(1):615. doi: 10.1186/s12887-026-06967-4. PMID- 42115918 OWN - NLM STAT- MEDLINE DCOM- 20260703 LR - 20260813 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 45 IP - 1 DP - 2026 May 11 TI - Examining the spread of nutrition-based misinformation by TikTok influencers: an experimental analysis of trust among young adults. LID - 10.1186/s41043-026-01321-x [doi] LID - 163 AB - BACKGROUND: Nutrition misinformation spreads rapidly on social media. Young adults particularly rely on influencers and platforms, such as TikTok, for nutrition information. This study examined young adult TikTok users' trust in nutrition information and nutrition influencers, exploring whether influencer qualifications and message accuracy influence trust. METHODS: We conducted an online experiment using Prolific and Centiment. A total of 1,035 TikTok users aged 18-26 years were recruited from four countries (USA, UK, Australia, Canada), with 1,016 included in the final analysis. Participants were randomly assigned to view one of six TikTok videos manipulating (1) influencer qualification (qualified vs neutral vs not qualified) and (2) information accuracy (accurate vs misinformation). Outcomes were self-reported trust in the influencer and trust in the message content, measured using validated multi-item scales. Differences across conditions were analysed using factorial ANCOVA models in SPSS. RESULTS: Trust in the influencer and trust in the message differed by qualification condition, with the highest trust observed when the influencer reported a nutrition qualification. Trust in both outcomes was also higher when the video contained accurate information compared with misinformation, with mean differences across conditions ranging from approximately 0.47 to 0.50 points on the scale. Post hoc analyses indicated lower trust in both the influencer and the message among Canadian participants relative to other countries. CONCLUSIONS: Influencer qualifications and information accuracy independently increase young adults' trust in TikTok nutrition content. These findings support encouraging qualified nutrition professionals to prominently disclose relevant credentials, ensure accuracy in original posts, and actively counter inaccurate nutrition content shared by others. CI - (c) 2026. The Author(s). FAU - Fox, Grace AU - Fox G AD - School of Modeling, Simulation and Training, University of Central Florida, Orlando, USA. grace.fox@ucf.edu. FAU - van der Werff, Lisa AU - van der Werff L AD - TrustLab, DCU Institute for Business and Society, Dublin City University, Dublin, Ireland. FAU - Santos, Guto AU - Santos G AD - TrustLab, DCU Institute for Business and Society, Dublin City University, Dublin, Ireland. FAU - Egli, Antonia AU - Egli A AD - School of Modeling, Simulation and Training, University of Central Florida, Orlando, USA. AD - University of Applied Sciences of the Grisons, Chur, Switzerland. FAU - Wood, Charles AU - Wood C AD - Collins College of Business, University of Tulsa, Tulsa, USA. FAU - Lynn, Theo AU - Lynn T AD - TrustLab, DCU Institute for Business and Society, Dublin City University, Dublin, Ireland. theo.lynn@dcu.ie. LA - eng PT - Journal Article DEP - 20260511 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Humans MH - *Trust MH - Young Adult MH - Adolescent MH - Adult MH - Female MH - Male MH - *Social Media MH - Canada MH - *Communication MH - Australia MH - United Kingdom MH - United States MH - Media Exposure MH - Digital Media PMC - PMC13330236 OTO - NOTNLM OT - Misinformation OT - Nutrition OT - Social media OT - TikTok OT - Trust COIS- Declarations. Ethics approval: This study was reviewed and approved by the Research Ethics Committee of Dublin City University (DCUREC/2023/220) and adheres to the WMA Declaration of Helsinki. All participants provided their informed consent prior to participation. Clinical trial number: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/12 06:33 MHDA- 2026/07/03 06:31 PMCR- 2026/05/11 CRDT- 2026/05/12 00:25 PHST- 2026/01/05 00:00 [received] PHST- 2026/04/03 00:00 [accepted] PHST- 2026/07/03 06:31 [medline] PHST- 2026/05/12 06:33 [pubmed] PHST- 2026/05/12 00:25 [entrez] PHST- 2026/05/11 00:00 [pmc-release] AID - 10.1186/s41043-026-01321-x [pii] AID - 1321 [pii] AID - 10.1186/s41043-026-01321-x [doi] PST - epublish SO - J Health Popul Nutr. 2026 May 11;45(1):163. doi: 10.1186/s41043-026-01321-x. PMID- 42115837 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261010 IS - 1532-0987 (Electronic) IS - 0891-3668 (Print) IS - 0891-3668 (Linking) VI - 45 IP - 11 DP - 2026 Nov 1 TI - Risk of Infective Endocarditis in Pediatric Staphylococcal Bacteremia: A 20-Year Cohort Study. PG - 925-928 LID - 10.1097/INF.0000000000005257 [doi] AB - OBJECTIVE: The prevalence of Staphylococcus aureus endocarditis (SAE) in children with S. aureus bacteremia (SAB) varies widely and is generally lower than that in adults. This study aimed to determine the prevalence of SAE in pediatric patients with SAB and to identify the associated clinical risk factors. METHODS: This retrospective study included all children 0-18 years old diagnosed with SAB at a university hospital in Thailand between 2003 and 2023, identified using International Statistical Classification of Diseases and Related Health Problems 10th Revision codes. Endocarditis was defined using the modified Duke criteria, in accordance with the 2023 European Society of Cardiology guidelines for the management of endocarditis. RESULTS: Among the 171 children with SAB, 15 (8.8%) met the criteria for definite infective endocarditis. Methicillin-sensitive S. aureus was the predominant pathogen in both uncomplicated SAB and SAB complicated by endocarditis. Congenital heart disease was significantly associated with SAE ( P = 0.02). Additional risk factors included protein-energy malnutrition (PEM) ( P = 0.04) and more than 2 positive blood cultures ( P = 0.001), whereas immunocompromised status was associated with a reduced risk ( P < 0.001). Both SAB and SAE were associated with prolonged hospitalization and increased mortality. CONCLUSIONS: SAE occurred in 8.8% of pediatric SAB cases. Congenital heart disease, protein-energy malnutrition and persistent bacteremia were key predictors of SAE. In settings where echocardiography is not immediately accessible, these clinical risk factors can guide the early identification of high-risk patients and support decisions regarding monitoring intensity and timely referral. Larger prospective studies are needed to validate these associations and to facilitate the development of practical prediction tools for pediatric SAE. CI - Copyright (c) 2026 The Author(s). Published by Wolters Kluwer Health, LLC. FAU - Pakotiprapha, Apisara AU - Pakotiprapha A AD - From the Division of Pediatric Cardiology, Department of Pediatrics, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. FAU - Chungsomprasong, Paweena AU - Chungsomprasong P AUID- ORCID: 0000-0003-0261-7007 FAU - Vijarnsorn, Chodchanok AU - Vijarnsorn C AUID- ORCID: 0000-0001-7124-2064 FAU - Chanthong, Prakul AU - Chanthong P AUID- ORCID: 0009-0006-1707-9378 FAU - Pacharapakornpong, Thita AU - Pacharapakornpong T AUID- ORCID: 0000-0001-9642-4614 FAU - Thammasate, Ploy AU - Thammasate P AUID- ORCID: 0009-0003-6155-0305 FAU - Srivichean, Auttapol AU - Srivichean A AUID- ORCID: 0009-0005-3925-8695 FAU - Durongpisitkul, Kritvikrom AU - Durongpisitkul K AUID- ORCID: 0000-0001-9295-516 FAU - Soongswang, Jarupim AU - Soongswang J AUID- ORCID: 0000-0001-7356-3881 LA - eng PT - Journal Article DEP - 20260512 PL - United States TA - Pediatr Infect Dis J JT - The Pediatric infectious disease journal JID - 8701858 SB - IM MH - Humans MH - Child MH - Child, Preschool MH - *Bacteremia/epidemiology/microbiology/complications MH - *Staphylococcal Infections/epidemiology/complications/microbiology MH - Female MH - Male MH - Infant MH - Retrospective Studies MH - Adolescent MH - Risk Factors MH - *Endocarditis, Bacterial/epidemiology/microbiology MH - Thailand/epidemiology MH - Infant, Newborn MH - Staphylococcus aureus MH - Prevalence PMC - PMC13649274 OTO - NOTNLM OT - bacteremia OT - infective endocarditis OT - pediatric COIS- The authors have no funding or conflicts of interest to disclose. EDAT- 2026/05/12 06:34 MHDA- 2026/10/09 05:30 PMCR- 2026/10/08 CRDT- 2026/05/12 00:03 PHST- 2026/04/01 00:00 [accepted] PHST- 2026/10/09 05:30 [medline] PHST- 2026/05/12 06:34 [pubmed] PHST- 2026/05/12 00:03 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - 00006454-990000000-01715 [pii] AID - PIDJ-264 [pii] AID - 10.1097/INF.0000000000005257 [doi] PST - ppublish SO - Pediatr Infect Dis J. 2026 Nov 1;45(11):925-928. doi: 10.1097/INF.0000000000005257. Epub 2026 May 12. PMID- 42115793 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260821 IS - 1578-1267 (Electronic) IS - 0301-0546 (Linking) VI - 54 IP - 3 DP - 2026 TI - Utility of the immunoglobulin E crosslinking-induced luciferase expression assay in buckwheat allergy diagnosis. PG - 42-48 LID - 10.15586/aei.v54i3.1395 [doi] AB - BACKGROUND: Buckwheat allergy carries a high risk of anaphylaxis. Although the oral food challenge (OFC) is the diagnostic gold standard, it can provoke severe reactions, leading many patients to adopt elimination diets. Conventional markers, including buckwheat-specific IgE (Bw-sIgE) and skin prick testing, have limited accuracy. The IgE crosslinking-induced luciferase expression (EXiLE) assay is a serum-based in vitro cell-activation test that has shown high accuracy for other food allergies. We evaluated its utility for buckwheat allergy. METHODS: This multicenter observational study in Japan enrolled participants with buckwheat-specific IgE >/= 0.35 U(A)/mL (n = 25), categorized as buckwheat allergy (BwA) or non-buckwheat allergy (non-BwA) based on OFC results. The EXiLE assay used crude buckwheat antigen at 0.1-1000 ng/mL. Diagnostic performance was compared using receiver operating characteristic (ROC) curves for EXiLE, Bw-sIgE, and the Bw-sIgE/total IgE ratio. RESULTS: Among 25 participants, the EXiLE assay demonstrated superior diagnostic performance compared to Bw-sIgE and the Bw-sIgE/total IgE ratio. The area under the ROC curve (AUC) was 0.96 at 10 ng/mL (1 ng/mL, 0.94), exceeding Bw-sIgE (0.68) and the Bw-sIgE/total IgE ratio (0.72). At optimal cutoffs, EXiLE achieved sensitivity 0.92, specificity 0.92, and LR+ 11.1 (versus LR+ 3.2 for Bw-sIgE and 2.5 for the IgE ratio), indicating fewer false positives and better overall accuracy. CONCLUSION: The EXiLE assay provides high diagnostic accuracy for IgE-mediated buckwheat allergy and, as a serum-based in vitro assay, may reduce reliance on OFC and help avoid unnecessary elimination diets. CI - Copyright: Kono T, et al. FAU - Kono, Toya AU - Kono T AD - Department of Pediatrics, Fujita Health University, Bantane Hospital, Aichi, Japan. FAU - Okamoto, Kaoru AU - Okamoto K AD - Department of Pediatrics, School of Medicine, Fujita Health University, Aichi, Japan. FAU - Mori, Yuji AU - Mori Y AD - Department of Pediatrics, Fujita Health University, Bantane Hospital, Aichi, Japan. FAU - Yoshikawa, Tetsushi AU - Yoshikawa T AD - Department of Pediatrics, School of Medicine, Fujita Health University, Aichi, Japan. FAU - Kondo, Yasuto AU - Kondo Y AD - Department of Pediatrics, Fujita Health University, Bantane Hospital, Aichi, Japan; ykondo@fujita-hu.ac.jp. LA - eng GR - This study was supported by a grant from the Consumer Affairs Agency, Government of Japan (grant for analysis of various food allergens and revision of materials to prevent health damage caused by immediate-type food allergies)./ PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260501 PL - Singapore TA - Allergol Immunopathol (Madr) JT - Allergologia et immunopathologia JID - 0370073 RN - 37341-29-0 (Immunoglobulin E) RN - EC 1.13.12.- (Luciferases) RN - 0 (Allergens) RN - 0 (Antigens, Plant) SB - IM MH - Humans MH - *Fagopyrum/immunology MH - *Immunoglobulin E/blood/immunology MH - *Food Hypersensitivity/diagnosis/immunology MH - Female MH - Male MH - *Luciferases/genetics/metabolism MH - Adult MH - Allergens/immunology MH - Antigens, Plant/immunology MH - Skin Tests MH - Japan MH - Sensitivity and Specificity MH - ROC Curve MH - Adolescent MH - Young Adult MH - Middle Aged OTO - NOTNLM OT - EXiLE OT - ROC curve OT - allergy OT - buckwheat OT - luciferase COIS- The authors declare no potential conflicts of interest with respect to research, authorship and/or publication of this article. EDAT- 2026/05/12 00:32 MHDA- 2026/05/12 06:34 CRDT- 2026/05/11 23:54 PHST- 2025/09/11 00:00 [received] PHST- 2025/12/01 00:00 [accepted] PHST- 2026/05/12 06:34 [medline] PHST- 2026/05/12 00:32 [pubmed] PHST- 2026/05/11 23:54 [entrez] AID - 10.15586/aei.v54i3.1395 [doi] PST - epublish SO - Allergol Immunopathol (Madr). 2026 May 1;54(3):42-48. doi: 10.15586/aei.v54i3.1395. eCollection 2026. PMID- 42115236 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 May 11 TI - Sports participation and obesity incidence in chinese adolescents: a 7-year prospective cohort study. LID - 10.1038/s41598-026-50212-y [doi] LID - 21526 AB - Adolescent obesity has risen to become a critical public health challenge around the world. According to the World Health Organization, roughly 340 million children and adolescents aged 5-19 were overweight or obese by 2016, representing a nearly sixfold increase since 1975. In China, rapid urbanization and shifting dietary patterns have accelerated this trend among school-age populations. Although physical activity is broadly considered protective against weight gain, longitudinal evidence that quantifies the magnitude of sports participation's effect on obesity incidence during adolescence remains sparse. We aimed to examine the dose-response relationship between sports participation intensity and seven-year obesity incidence among Chinese adolescents, and to identify subgroup-specific effect modification by sex, age, and baseline body mass index. We conducted a prospective cohort study drawing on data from the National Adolescent Health Surveillance System. A total of 89,532 initially non-obese Chinese adolescents aged 12-15 years were followed from 2016 to 2023. Sports participation intensity was assessed biannually through validated questionnaires, and obesity incidence was ascertained using WHO age- and sex-specific BMI criteria. Cox proportional hazards regression models were fitted with adjustment for demographic, socioeconomic, and time-varying behavioral confounders. Propensity score matching and marginal structural models served as supplementary analytical approaches to strengthen causal inference. Over 523,847 person-years of observation, 8,947 incident obesity cases were identified (17.1 per 1,000 person-years). Compared with minimal physical activity, high sports participation (>/= 300 min/week) was associated with a 58% lower obesity risk (HR = 0.42, 95% CI 0.37-0.48), and a clear dose-response gradient was observed. Moderate and low participation showed intermediate protective effects (HR = 0.61 and 0.73, respectively). These associations held up across multiple sensitivity analyses and were stronger among boys than girls. Sustained sports participation during adolescence substantially reduces obesity incidence in a dose-dependent manner. These findings offer compelling support for physical activity promotion policies and school-based interventions targeting this critical developmental period. This study was reported following the STROBE guidelines for observational studies. CI - (c) 2026. The Author(s). FAU - Qiu, Derun AU - Qiu D AD - College of P.E and Sports, Beijing Normal University, Beijing, Beijing, 100875, China. FAU - Dai, Chunmin AU - Dai C AD - International Football Education School, Jilin Agriculture University, Changchun, 130118, Jilin, China. dcm075213@163.com. LA - eng PT - Journal Article DEP - 20260511 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - Chinese people SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Incidence MH - Prospective Studies MH - China/epidemiology MH - Child MH - *Sports MH - Body Mass Index MH - *Pediatric Obesity/epidemiology MH - *Exercise MH - Proportional Hazards Models MH - East Asian People PMC - PMC13351051 OTO - NOTNLM OT - Adolescent obesity OT - Cox proportional hazards model OT - Dose-response relationship OT - Physical activity OT - Prospective cohort study OT - Sports participation COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval and consent to participate: This study was approved by the Research Ethics Committee of Beijing Normal University (Reference Number: BNU-IRB-2016-037) and the Ethics Review Board of Jilin Agriculture University (Reference Number: JAU-ERB-2016-024). All procedures were conducted in accordance with the Declaration of Helsinki and relevant Chinese national regulations. Written informed consent was obtained from all participants and their legal guardians prior to enrollment. Consent for publication: All authors have reviewed and approved the final manuscript for publication. No identifiable individual participant data or images are included. All participants provided consent for their anonymized data to be used for research purposes and publication. EDAT- 2026/05/12 00:33 MHDA- 2026/07/11 04:10 PMCR- 2026/05/11 CRDT- 2026/05/11 23:16 PHST- 2025/11/16 00:00 [received] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/07/11 04:10 [medline] PHST- 2026/05/12 00:33 [pubmed] PHST- 2026/05/11 23:16 [entrez] PHST- 2026/05/11 00:00 [pmc-release] AID - 10.1038/s41598-026-50212-y [pii] AID - 50212 [pii] AID - 10.1038/s41598-026-50212-y [doi] PST - epublish SO - Sci Rep. 2026 May 11;16(1):21526. doi: 10.1038/s41598-026-50212-y. PMID- 42114847 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260511 LR - 20260813 IS - 2005-3711 (Print) IS - 1598-7876 (Electronic) IS - 1225-8245 (Linking) VI - 69 IP - 3 DP - 2026 May TI - Wearable Technologies for Clinical Assessment and Monitoring in Pediatric Neurodevelopmental Disorders : A Narrative Review. PG - 361-370 LID - 10.3340/jkns.2026.0036 [doi] AB - Pediatric neurodevelopmental disorders (NDDs) as defined by the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Text Revision : intellectual disabilities, communication disorders, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder (ASD), specific learning disorder, and motor disorders together with closely associated pediatric neurological conditions such as cerebral palsy (CP) and epilepsy, present with symptom fluctuations and variable performance, making longitudinal assessment challenging. Conventional clinical scales, questionnaires, and caregiver diaries are largely subjective and offer limited temporal coverage. This review examines wearable technologies applicable to these conditions, focusing on measurable digital biomarkers and real-world clinical application. A narrative review was performed. Wearable technologies were categorized into motion trackers (accelerometers/gyroscopes, inertial measurement units [IMUs]), physiological monitors (photoplethysmography-derived heart rate and heart rate variability, and electrodermal activity), wearable electroencephalography (EEG)/brain sensors, smart glasses/cameras, and textile-based wearables. IMU and accelerometer based systems achieved posture and gait classification accuracies of approximately 85%, distinguished children with ADHD from controls with 80-90% accuracy, and detected stereotyped behaviors in children with ASD with sensitivities exceeding 90%. Wearable EEG demonstrated high performance for ASD classification (accuracy, 96%; sensitivity, 100%) and for automated sleep staging in epilepsy(accuracy, 80.8-83.5%), and also enabled seizure-related signal monitoring through detection of ictal fast activity. For tonic-clonic seizures, wearable devices achieved sensitivities of 89-94%, whereas tonic-seizure detection performance remains limited. Smartwatch vibrotactile stimulation reduced stereotyped behaviors and improved task performance, and wrist-worn biosignals enabled prediction of aggressive behavior approximately three minutes before onset. Augmented reality based smart glasses supported social-communication coaching in children with ASD. In children with CP, smart-shoe systems classified daily activities with high accuracy and quantified gait asymmetry. Wearables enable objective and continuous assessment of symptoms and behaviors in children with NDDs and related pediatric neurological conditions across real-world environments and are expanding toward personalized intervention. Remaining challenges include integration into clinical workflows (electronic medical record [EMR] linkage, clinician-friendly data summarisation, and reimbursement pathways), ethical and privacy considerations, and standardisation of validation protocols. FAU - Lee, Eun Jae AU - Lee EJ AD - Division of Pediatric Neurology, Department of Pediatrics, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul, Korea. AD - Department of Community Health Nursing, Ewha Womans University, Seoul, Korea. FAU - Kim, Woojoong AU - Kim W AD - Division of Pediatric Neurology, Department of Pediatrics, Pediatric Clinical Neuroscience Center, Seoul National University Children's Hospital, Seoul, Korea. LA - eng PT - Journal Article DEP - 20260430 PL - Korea (South) TA - J Korean Neurosurg Soc JT - Journal of Korean Neurosurgical Society JID - 101467054 PMC - PMC13172776 OTO - NOTNLM OT - Biomarkers OT - Neurodevelopmental disorders OT - Remote patient monitoring OT - Wearable electronic devices COIS- Conflicts of interest No potential conflict of interest relevant to this article was reported. EDAT- 2026/05/12 00:32 MHDA- 2026/05/12 00:33 PMCR- 2026/05/01 CRDT- 2026/05/11 20:31 PHST- 2026/02/04 00:00 [received] PHST- 2026/04/26 00:00 [accepted] PHST- 2026/05/12 00:33 [medline] PHST- 2026/05/12 00:32 [pubmed] PHST- 2026/05/11 20:31 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - jkns.2026.0036 [pii] AID - jkns-2026-0036 [pii] AID - 10.3340/jkns.2026.0036 [doi] PST - ppublish SO - J Korean Neurosurg Soc. 2026 May;69(3):361-370. doi: 10.3340/jkns.2026.0036. Epub 2026 Apr 30. PMID- 42114824 OWN - NLM STAT- MEDLINE DCOM- 20261026 LR - 20261028 IS - 1543-3072 (Electronic) IS - 1056-6716 (Linking) VI - 35 IP - 8 DP - 2026 Nov 1 TI - A Slim-Fit Knee Brace for Young Adults With a Symptomatic Knee Following Anterior Cruciate Ligament Reconstruction: A Feasibility Randomized Controlled Trial. PG - 641-651 LID - 10.1123/jsr.2025-0430 [doi] AB - CONTEXT: Early-onset osteoarthritis and associated symptoms are common after anterior cruciate ligament reconstruction (ACLR), but evidence for effective treatments is limited. We aimed to assess the feasibility of a slim-fit knee brace in young adults with a symptomatic knee post-ACLR. DESIGN: 6-week feasibility randomized controlled trial. METHODS: Participants (aged 18-45, 1-8 y post-ACLR) with a symptomatic knee were randomized (2:1) to (1) a slim-fit knee brace group, to wear >/=1 hour daily and during aggravating activities; or (2) a no brace control group. Feasibility was assessed via eligibility, enrollment, recruitment, dropouts, adverse events, and adherence (temperature sensor). Acceptability was assessed via treatment satisfaction (100-point scale) and explored in semistructured interviews and analyzed thematically. Secondary outcomes included 6-week change in Knee injury and Osteoarthritis Outcome Score, Tampa Scale of Kinesiophobia, and hop performance. RESULTS: Of 48 participants screened, 24 (50%) were eligible and 21 (88%) enrolled over 6 months (52% male, mean age 31 [6] y, n = 14 brace, n = 7 control). One control participant was lost to follow-up (5% dropout). In the brace group, there were 2 serious and 3 minor unrelated adverse events, and 6 minor skin-related events; the control group had 2 minor events. Brace adherence averaged >/=1 hour per day on 43% of days (participant range 0%-78%). For acceptability, satisfaction was rated 70/100 (19). Fourteen interviews identified themes of perceived effectiveness (eg, improved confidence, pain relief), practical challenges to brace wear (eg, fit, clothing compatibility), and integration into daily life (eg, ease of use, social perceptions). The brace showed potential for worthwhile treatment effects for hop performance, and most Knee injury and Osteoarthritis Outcome Score subscales, but not for kinesiophobia. CONCLUSIONS: A full-scale randomized controlled trial is feasible, as recruitment and retention targets were met, although adherence requires refinement. The brace showed promising functional benefits, supporting further evaluation as a low-burden intervention for young adults with a symptomatic knee post-ACLR. FAU - Savage, Matthew AU - Savage M AUID- ORCID: 0009-0009-0807-6249 AD - La Trobe Sport and Exercise Medicine Research Center, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC, Australia. AD - Australian IOC Research Center, La Trobe University, Melbourne, VIC, Australia. FAU - Mentiplay, Benjamin F AU - Mentiplay BF AUID- ORCID: 0000-0002-4360-8310 AD - La Trobe Sport and Exercise Medicine Research Center, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC, Australia. AD - Australian IOC Research Center, La Trobe University, Melbourne, VIC, Australia. AD - Sport and Exercise Science, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC, Australia. FAU - Bruder, Andrea M AU - Bruder AM AUID- ORCID: 0000-0001-5422-5756 AD - La Trobe Sport and Exercise Medicine Research Center, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC, Australia. AD - Australian IOC Research Center, La Trobe University, Melbourne, VIC, Australia. AD - Department of Physiotherapy, Podiatry and Prosthetics and Orthotics, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC, Australia. FAU - Slater, Harriette AU - Slater H AD - La Trobe Sport and Exercise Medicine Research Center, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC, Australia. AD - Australian IOC Research Center, La Trobe University, Melbourne, VIC, Australia. FAU - Serighelli, Fernanda AU - Serighelli F AUID- ORCID: 0000-0002-0057-8596 AD - La Trobe Sport and Exercise Medicine Research Center, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC, Australia. AD - Australian IOC Research Center, La Trobe University, Melbourne, VIC, Australia. FAU - Couch, Jamon L AU - Couch JL AUID- ORCID: 0009-0009-6481-041X AD - La Trobe Sport and Exercise Medicine Research Center, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC, Australia. AD - Australian IOC Research Center, La Trobe University, Melbourne, VIC, Australia. AD - Arthritis Research Canada, Vancouver, BC, Canada. FAU - Bullock, Laurna AU - Bullock L AUID- ORCID: 0000-0002-4193-1835 AD - Centre for Musculoskeletal Research, School of Medicine, Keele University, Keele, United Kingdom. FAU - Culvenor, Adam G AU - Culvenor AG AUID- ORCID: 0000-0001-9491-0264 AD - La Trobe Sport and Exercise Medicine Research Center, School of Allied Health, Human Services and Sport, La Trobe University, Melbourne, VIC, Australia. AD - Australian IOC Research Center, La Trobe University, Melbourne, VIC, Australia. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260511 PL - United States TA - J Sport Rehabil JT - Journal of sport rehabilitation JID - 9206500 SB - IM MH - Humans MH - *Braces MH - Female MH - Male MH - *Anterior Cruciate Ligament Reconstruction/adverse effects MH - Young Adult MH - Adult MH - Feasibility Studies MH - Patient Satisfaction MH - Adolescent MH - Kinesiophobia MH - *Osteoarthritis, Knee/therapy/etiology MH - Patient Compliance MH - *Anterior Cruciate Ligament Injuries/surgery OTO - NOTNLM OT - ACL reconstruction OT - hop performance OT - osteoarthritis OT - physical activity OT - physiotherapy EDAT- 2026/05/12 00:32 MHDA- 2026/10/26 23:26 CRDT- 2026/05/11 19:32 PHST- 2025/11/02 00:00 [received] PHST- 2026/03/12 00:00 [revised] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/10/26 23:26 [medline] PHST- 2026/05/12 00:32 [pubmed] PHST- 2026/05/11 19:32 [entrez] AID - 10.1123/jsr.2025-0430 [doi] PST - epublish SO - J Sport Rehabil. 2026 May 11;35(8):641-651. doi: 10.1123/jsr.2025-0430. Print 2026 Nov 1. PMID- 42114675 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 74 DP - 2026 Aug TI - Assessing the validity of a portable indirect calorimetry device in a pediatric sample. PG - 103320 LID - S2405-4577(26)00416-X [pii] LID - 10.1016/j.clnesp.2026.103320 [doi] AB - BACKGROUND & AIMS: Accurate and scalable tools to measure metabolic markers, such as resting energy expenditure (REE) and respiratory quotient (RQ) are essential for the success of personalized nutrition and weight management programs. These measures are particularly relevant for children, as their metabolism and energy needs fluctuate widely during development. Predictive equations are limited due to their poor precision at the individual level, particularly in children. While the Douglas Bag method remains the gold standard for measuring REE and gas exchange, it is impractical for routine pediatric use due to high monetary cost, long measurement time, and expertise requirements. The Breezing Med device could potentially serve as a portable, non-invasive alternative for accurately assessing metabolism, but it has not been validated in children. METHODS: The purpose of this study was to validate the Breezing Med device, a handheld, portable indirect calorimetry tool, against the gold-standard Douglas Bag method for measuring REE and gas exchange parameters in a pediatric sample. Nineteen children (mean age: 10.5 +/- 3.7 years; range: 5-17 years) completed resting, fasted testing with the Breezing Med and Douglas Bag system. Agreement was assessed using concordance correlation coefficients (CCC), bias analyses, and Bland-Altman plots. Root mean square error (RMSE) and +/-10% accuracy thresholds were also calculated to evaluate overall prediction error. Results were also compared to predictive energy expenditure equations that are commonly used for pediatric populations. RESULTS: Breezing Med demonstrated good agreement with Douglas Bag for REE (CCC = 0.88; bias correction factor = 0.93), although it systematically overestimated REE by 126.8 kcal/day (9.8%) and REE/kg by 4.5 kcal/kg/day (12.0%). Compared to the Douglas Bag, the Breezing Med overestimated VO(2) by 13.8%, while differences in VCO(2) were negligible (mean bias = -1.1 mL/min, -0.6%). In contrast, predictive equations showed smaller mean bias but greater variability, lower CCC values, and weaker overall agreement compared to Breezing Med. Breezing Med demonstrated lower overall prediction error than predictive equations. RQ showed negative bias (mean difference = -0.10) with poor categorical agreement (kappa(w) = 0.12). CONCLUSIONS: Breezing Med provides a scalable, non-invasive approach for measuring REE and gas exchange in children but appears to systematically overestimate VO(2) magnitudes. This led to overestimations of REE and poor RQ agreement in our sample. These findings suggest the device demonstrates good precision but reduced accuracy relative to the Douglas Bag method. Software calibration or correction factors would need to be developed to correct these overestimates before widespread use in clinical settings can be recommended. Testing on a larger and more diverse pediatric sample would be needed to develop and validate appropriate correction factors. With appropriate calibration, Breezing Med holds promise as a useful and accessible tool for individualized metabolic assessment, particularly in settings where traditional gold-standard methods are impractical. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Neuwald, Nicholas V AU - Neuwald NV AD - Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA; Center for Ingestive Behaviors, University at Buffalo, Buffalo, NY, USA. Electronic address: nneuwald@buffalo.edu. FAU - Temple, Jennifer L AU - Temple JL AD - Center for Ingestive Behaviors, University at Buffalo, Buffalo, NY, USA; Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY, USA. FAU - Epstein, Leonard H AU - Epstein LH AD - Department of Pediatrics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA; Center for Ingestive Behaviors, University at Buffalo, Buffalo, NY, USA. LA - eng PT - Journal Article PT - Validation Study DEP - 20260509 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM MH - Humans MH - *Calorimetry, Indirect/instrumentation/methods MH - Child MH - Child, Preschool MH - Adolescent MH - Reproducibility of Results MH - Female MH - Male MH - Energy Metabolism MH - Basal Metabolism OTO - NOTNLM OT - Breezing Med OT - Indirect calorimetry OT - Pediatric metabolism OT - Point of care OT - Respiratory quotient OT - Resting energy expenditure COIS- Conflict of interest The authors declare no conflicts of interest related to this work. EDAT- 2026/05/12 00:33 MHDA- 2026/06/27 00:56 CRDT- 2026/05/11 19:14 PHST- 2025/10/16 00:00 [received] PHST- 2026/04/13 00:00 [revised] PHST- 2026/05/01 00:00 [accepted] PHST- 2026/06/27 00:56 [medline] PHST- 2026/05/12 00:33 [pubmed] PHST- 2026/05/11 19:14 [entrez] AID - S2405-4577(26)00416-X [pii] AID - 10.1016/j.clnesp.2026.103320 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2026 Aug;74:103320. doi: 10.1016/j.clnesp.2026.103320. Epub 2026 May 9. PMID- 42114063 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260511 LR - 20260813 IS - 2152-7202 (Electronic) IS - 2152-7202 (Linking) VI - 18 DP - 2026 May 11 TI - Theorizing How Context Influences School-Based Interventions That Support Children's Weight Management: Co-Producing a Refined Logic Model. PG - e80309 LID - 10.2196/80309 [doi] LID - e80309 AB - BACKGROUND: Schools can play an important role in supporting child weight management, with evidence suggesting that school-based interventions can be effective, albeit with substantial variation. Part of this variation could reflect the different contexts in which interventions are implemented. Our previous work found that co-production of research and adopting a complex systems model of evidence can be transformative for understanding this context. However, less is known about how co-production helps prioritize elements for exploration or how we should assess the value of co-production in research development. This study addresses these gaps by co-producing a refined logic model (a graphical representation of a theory) of the contextual influencers on school-based weight management to support public health research and policymaking. OBJECTIVE: This study aimed to (1) identify critical contextual features to consider when planning school-based weight management interventions targeting the intersection of physical activity, healthy eating, and mental well-being; (2) understand the difference that we, as co-producers, make when working together; and (3) identify learning about the process of producing and refining a logic model. METHODS: Through collaborative workshops, we refined an existing theoretical framework identifying contextual influences. We critically reviewed existing frameworks for evaluating co-production, creating a new evaluation approach for our collaborative practices, complemented by surveys and workshop feedback. RESULTS: Six criteria were identified and applied to refine the original logic model, significantly reducing complexity. The revised model prioritized systemic and policy factors, emphasizing environmental structuring rather than individual behaviors, and incorporated a stronger emphasis on life course factors. We used a tool and process developed specifically for this project, which may have broader utility for other research projects, to understand the value of working together. Many of us recognized that the impacts of the project and working together were unexpected and, for some of us, transformational. Nevertheless, we did identify some factors that could support co-production in future. These included the need for clearer initial discussions on positionalities, role expectations, and autonomy. CONCLUSIONS: Our refined model aligns with broader calls to shift away from narratives centered on personal responsibility in children's health. This research further demonstrates the practical value and feasibility of co-produced theoretical frameworks, effectively reshaping the focus of research from the outset and challenging established assumptions. CI - (c) Dylan Kneale, Rachael C Edwards, Meena Khatwa, Phuong Tu Nguyen, Sajid Saleem, Sylvia Chaires, Lisa Richardson, Vanessa Bennett, Tabitha Evans, Alison O'Mara-Eves. Originally published in Journal of Participatory Medicine (https://jopm.jmir.org). FAU - Kneale, Dylan AU - Kneale D AUID- ORCID: 0000-0002-7016-978X AD - EPPI Centre, UCL Social Research Institute, University College London, C/O: 20 Bedford Way, London, WC1H 0AL, United Kingdom, 44 02076126020. FAU - Edwards, Rachael C AU - Edwards RC AUID- ORCID: 0000-0003-4717-7615 AD - EPPI Centre, UCL Social Research Institute, University College London, C/O: 20 Bedford Way, London, WC1H 0AL, United Kingdom, 44 02076126020. FAU - Khatwa, Meena AU - Khatwa M AUID- ORCID: 0000-0002-2392-6258 AD - EPPI Centre, UCL Social Research Institute, University College London, C/O: 20 Bedford Way, London, WC1H 0AL, United Kingdom, 44 02076126020. FAU - Nguyen, Phuong Tu AU - Nguyen PT AUID- ORCID: 0009-0009-6761-0261 AD - Co-Production Collective, UCL Culture, University College London, London, United Kingdom. FAU - Saleem, Sajid AU - Saleem S AUID- ORCID: 0000-0001-6021-077X AD - Co-Production Collective, UCL Culture, University College London, London, United Kingdom. FAU - Chaires, Sylvia AU - Chaires S AUID- ORCID: 0009-0009-6612-3517 AD - Co-Production Collective, UCL Culture, University College London, London, United Kingdom. FAU - Richardson, Lisa AU - Richardson L AUID- ORCID: 0000-0002-9753-0184 AD - Co-Production Collective, UCL Culture, University College London, London, United Kingdom. FAU - Bennett, Vanessa AU - Bennett V AUID- ORCID: 0000-0001-9710-9042 AD - Co-Production Collective, UCL Culture, University College London, London, United Kingdom. FAU - Evans, Tabitha AU - Evans T AUID- ORCID: 0009-0000-6240-0091 AD - EPPI Centre, UCL Social Research Institute, University College London, C/O: 20 Bedford Way, London, WC1H 0AL, United Kingdom, 44 02076126020. FAU - O'Mara-Eves, Alison AU - O'Mara-Eves A AUID- ORCID: 0000-0002-0359-6423 AD - EPPI Centre, UCL Social Research Institute, University College London, C/O: 20 Bedford Way, London, WC1H 0AL, United Kingdom, 44 02076126020. LA - eng PT - Journal Article DEP - 20260511 PL - Canada TA - J Particip Med JT - Journal of participatory medicine JID - 101539422 PMC - PMC13160485 OTO - NOTNLM OT - children's health OT - co-production OT - logic model OT - prioritisation OT - social determinants of health COIS- Conflicts of Interest: None declared. EDAT- 2026/05/11 18:32 MHDA- 2026/05/11 18:33 PMCR- 2026/05/11 CRDT- 2026/05/11 16:53 PHST- 2025/07/08 00:00 [received] PHST- 2026/03/05 00:00 [revised] PHST- 2026/03/06 00:00 [accepted] PHST- 2026/05/11 18:33 [medline] PHST- 2026/05/11 18:32 [pubmed] PHST- 2026/05/11 16:53 [entrez] PHST- 2026/05/11 00:00 [pmc-release] AID - v18i1e80309 [pii] AID - 80309 [pii] AID - 10.2196/80309 [doi] PST - epublish SO - J Particip Med. 2026 May 11;18:e80309. doi: 10.2196/80309. PMID- 42114021 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260511 LR - 20260813 IS - 2369-2529 (Print) IS - 2369-2529 (Electronic) IS - 2369-2529 (Linking) VI - 13 DP - 2026 May 11 TI - Smartphone App-Delivered Mindfulness-Based Intervention for Concussion in Adolescents (MBI-4-mTBI): Feasibility Randomized Controlled Trial. PG - e84623 LID - 10.2196/84623 [doi] LID - e84623 AB - BACKGROUND: Persisting symptoms affect about one-third of youth following concussion. Mental health history, distress, and coping style are key predictors of prolonged recovery. Early and scalable psychological interventions, such as mindfulness-based intervention (MBI) delivered via smartphones, may improve patients' ability to regulate their emotions and neurophysiologically recover, reducing overall symptom burden. However, no digital therapeutic (DTx) trials in adolescents experiencing concussion exist. OBJECTIVE: This study primarily aimed to assess the feasibility of conducting a larger randomized controlled trial (RCT) evaluating the effectiveness of a DTx-MBI in adolescents with a concussion compared with an attention-matched sham intervention. METHODS: This was a Health Canada-regulated, parallel-group, blinded, single-crossover feasibility RCT. Adolescents aged 12 to <18 years presenting to a Pediatric Emergency Department or interdisciplinary concussion clinic within 7 days of a physician-diagnosed concussion were approached for participation from November 2022 to June 2024. After providing consent, participants were randomized (1:1), stratified by sex, to either the experimental group (DTx-MBI) or the control group (sham, attention-matched math puzzle game). The DTx-MBI was delivered via the AmDTx platform (Mobio Interactive Pte Ltd, Singapore) as a custom-designed 4-to-8-week program of 8 standardized modules for adolescents with concussion, including audio-recorded guided mindfulness exercises, goal setting, journaling, and psychoeducation. The control intervention, delivered through the same interface, excluded mindfulness content and instead featured the open-source game "2048". Participants in both groups were encouraged to engage with the app for at least 10 minutes/day, at least 4 days/week. Feasibility criteria to support progression to a full-scale RCT included: eligibility rate >40% of those screened; recruitment rate >50% of eligible participants randomized; intervention credibility >70% scoring above the midpoint on the credibility and expectancy questionnaire (CEQ) at 1 week; retention >75% of randomized participants completing 4-week outcomes; and adherence >70% completing 10 minutes of intervention on at least 4 days/week for 4 weeks. RESULTS: A total of 124 out of 195 (63.6%) screened youth met eligibility criteria. Of these, 99/124 (79.8%) consented and were randomized to either the DTx-MBI group (n=49, median [IQR] age=15.28 [13.66-16.19] years, 30 [61.2%] female) or the Sham group (n=50, median [IQR] age=14.92 [13.32-16.71] years, 30 [60.0%] female). Credibility was high, with 62/83 (74.7%) of participants scoring above the credibility midpoint (DTx-MBI: 75.0%; Sham: 74.4%). Retention was strong, with 89/99 (89.9%) of participants completing the 4-week outcomes (DTx-MBI: 89.8%; control: 90.0%). Overall adherence was moderate (54/99 [54.5%]; DTx-MBI: 59.2%; control: 50.0%), and a little higher among outcome assessment completers (53/89 [59.6%]; DTx-MBI: 63.6%; Sham: 55.6%). Feasibility indicators were similar between groups. CONCLUSIONS: This feasibility trial supports the implementation of a larger RCT, with modifications to enhance adherence, to rigorously evaluate the clinical efficacy of the DTx-MBI. By targeting modifiable psychological risk factors through a scalable digital platform, DTx-MBI could be a low-burden, cost-effective adjunct to pediatric concussion care. CI - (c) Veronik Sicard, Molly Cairncross, Roger Zemek, Noah D Silverberg, Gary S Goldfield, Nick Reed, Bechara J Saab, Andra Smith, Andree-Anne Ledoux. Originally published in JMIR Rehabilitation and Assistive Technology (https://rehab.jmir.org). FAU - Sicard, Veronik AU - Sicard V AUID- ORCID: 0000-0003-2452-934X AD - Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON, K1H 5B2, Canada, 1 613-737-7600, 1 613-738-4804. FAU - Cairncross, Molly AU - Cairncross M AUID- ORCID: 0000-0003-1926-0569 AD - Department of Psychology, Simon Fraser University, Burnaby, BC, Canada. AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. AD - Rehabilitation Research Program, Centre for Aging SMART, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada. FAU - Zemek, Roger AU - Zemek R AUID- ORCID: 0000-0001-7807-2459 AD - Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON, K1H 5B2, Canada, 1 613-737-7600, 1 613-738-4804. AD - Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada. FAU - Silverberg, Noah D AU - Silverberg ND AUID- ORCID: 0000-0001-6378-148X AD - Rehabilitation Research Program, Centre for Aging SMART, Vancouver Coastal Health Research Institute, Vancouver, BC, Canada. AD - Department of Psychology, University of British Columbia, Vancouver, BC, Canada. AD - Djavad Mowafaghian Centre for Brain Health, Vancouver, BC, Canada. FAU - Goldfield, Gary S AU - Goldfield GS AUID- ORCID: 0000-0001-6216-7824 AD - Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON, K1H 5B2, Canada, 1 613-737-7600, 1 613-738-4804. AD - Department of Pediatrics, University of Ottawa, Ottawa, ON, Canada. AD - School of Psychology, University of Ottawa, Ottawa, ON, Canada. FAU - Reed, Nick AU - Reed N AUID- ORCID: 0000-0001-9360-7888 AD - Department of Occupational Science & Occupational Therapy, University of Toronto, Toronto, ON, Canada. FAU - Saab, Bechara J AU - Saab BJ AUID- ORCID: 0000-0003-1673-129X AD - Mobio Interactive, Singapore, Singapore. FAU - Smith, Andra AU - Smith A AUID- ORCID: 0000-0002-1212-2473 AD - School of Psychology, University of Ottawa, Ottawa, ON, Canada. FAU - Ledoux, Andree-Anne AU - Ledoux AA AUID- ORCID: 0000-0002-3163-0844 AD - Children's Hospital of Eastern Ontario Research Institute, 401 Smyth Road, Ottawa, ON, K1H 5B2, Canada, 1 613-737-7600, 1 613-738-4804. AD - Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, ON, Canada. AD - University of Ottawa Brain and Mind Research Institute, University of Ottawa, Ottawa, ON, Canada. LA - eng PT - Journal Article DEP - 20260511 PL - Canada TA - JMIR Rehabil Assist Technol JT - JMIR rehabilitation and assistive technologies JID - 101703412 PMC - PMC13160406 OTO - NOTNLM OT - clinical trial OT - concussion OT - digital therapeutics OT - eHealth OT - mHealth OT - mild traumatic brain injury OT - mindfulness OT - pediatric OT - psychological intervention OT - youth COIS- Conflicts of Interest: VS is supported by a Canadian Institutes of Health Research postdoctoral fellowship and receives royalties for the publication of a book on concussion by Flammarion. MC is one of the authors of the Mindfulness-Based Intervention for Concussion protocol used in this study, but she did not receive any financial benefit. She has received competitively funded research grants from the Canadian Institutes of Health Research (CIHR) and Michael Smith Health Research BC. RZ received financial support through competitively funded research grants from the Canadian Institutes of Health Research, Ontario Neurotrauma Foundation, Physician Services Incorporated Foundation, Children's Hospital of Eastern Ontario Foundation, University of Ottawa Brain and Mind Research Institute, Ontario Brain Institute, National Football League, Ontario Ministry of Health, Public Health Agency of Canada, Health Canada, Parachute Canada, and Ontario SPOR Support Unit. RZ was supported by a Tier 1 Clinical Research Chair in Pediatric Concussion from the University of Ottawa. All grant funding goes directly to the institution. RZ sits on the board of directors for the North American Brain Injury Society, which is a volunteer (unpaid) role. RZ is a founding partner and a minority shareholder of 360 Concussion Care (a learning health system and network of interdisciplinary concussion clinics in Ontario); no proceeds have been transferred to RZ. NR holds a Canada Research Chair (Tier 2) in Pediatric Concussion and has received research funding from the Canadian Institutes of Health Research (CIHR), Social Sciences and Humanities Research Council (SSHRC), Ontario Neurotrauma Foundation (ONF), Public Health Agency of Canada (PHAC), Parachute Canada, Special Olympics Canada, Greater Toronto Hockey League, Dr. Tom Pashby Sport Safety Fund, Holland Bloorview Kids Rehabilitation Hospital and Scotiabank. NR is an Executive Board Member for the International Pediatric Brain Injury Society (IPIBS), which is an unpaid and volunteer role. All other authors declare no other conflicts of interest. BJS is the Chief Scientist and CEO of Mobio Interactive PTE LTD (Singapore), the parent company of Mobio Interactive Inc. (Toronto, Canada), and he owned approximately 22% of the company at the time of manuscript submission. BJS exclusively served as a technical liaison for the study and did not contribute to the specific study design, select the outcome measures, nor did he directly contribute to, or have influence over, data collection or analysis. AAL is one of the authors of the Mindfulness-Based Intervention for Concussion protocol used in this study, but she did not receive any financial benefit. Andree-Anne Ledoux has received competitively funded research grants from the Canadian Institutes of Health Research (CIHR), Ontario Neurotrauma Foundation (ONF), Physician Services Incorporated (PSI) Foundation, CHEO Foundation, Ontario Brain Institute (OBI), and University of Ottawa Brain and Mind Research. AAL received funding from the Ontario Brain Institute Neurotech Early Research & Development Program for a separate component of the study. AAL has no other conflict of interest to disclose. EDAT- 2026/05/11 18:33 MHDA- 2026/05/11 18:34 PMCR- 2026/05/11 CRDT- 2026/05/11 15:53 PHST- 2025/09/22 00:00 [received] PHST- 2026/03/12 00:00 [revised] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/05/11 18:34 [medline] PHST- 2026/05/11 18:33 [pubmed] PHST- 2026/05/11 15:53 [entrez] PHST- 2026/05/11 00:00 [pmc-release] AID - v13i1e84623 [pii] AID - 84623 [pii] AID - 10.2196/84623 [doi] PST - epublish SO - JMIR Rehabil Assist Technol. 2026 May 11;13:e84623. doi: 10.2196/84623. PMID- 42113963 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260511 LR - 20260813 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 9 DP - 2026 May 11 TI - Usability and Acceptability of a Digital Health App to Support Infant Feeding and Lifestyle Behaviors: Mixed Methods Pilot Study. PG - e86139 LID - 10.2196/86139 [doi] LID - e86139 AB - BACKGROUND: Childhood obesity is a global health concern with long-term cardiometabolic and psychosocial consequences. Establishing healthy feeding and lifestyle behaviors from infancy is critical to population health efforts with a life course perspective. Recently, digital health applications have gained traction in reaching out to parents and promoting healthy feeding behaviors. OBJECTIVE: The aim of this study was to evaluate the usability and acceptability of the Feeding, Lifestyle, Activity Goals app in providing parents with evidence-based guidance and tailored advice to promote healthier eating behaviors and lifestyle habits among infants. METHODS: We conducted a mixed methods pilot study among parents of infants aged 0 to 24 months recruited from a tertiary maternity and children's hospital in Singapore. Participants used the digital health app for 7 days. Usability was assessed using the validated System Usability Scale (score range 0-100, with >/=70 indicating acceptable usability). Acceptability was explored via open-ended questionnaires on satisfaction, relevance, and user experience, with qualitative data analyzed thematically by 2 independent coders to ensure rigor. RESULTS: A total of 26 parents of infants aged 3 weeks to 23 months completed the study. The app demonstrated good usability, with a mean System Usability Scale score of 71.3 (SD 11.0). Parents valued its role in organizing infant care; promoting self-reflection on parenting practices; and providing personalized, evidence-based recommendations. These benefits were particularly appreciated by first-time parents and those with multiple caregiving responsibilities. Challenges included an unintuitive user interface, high manual data entry burden, and advisory content that was occasionally overly general or text heavy. These insights highlight clear priorities for onward efforts in optimization. CONCLUSIONS: Results of our mixed methods evaluation indicate that our digital health app demonstrated good usability and acceptability among parents of infants. Targeted refinements to the interface, data entry processes, and content delivery are warranted before large-scale evaluation to determine its impact on early-life health behaviors and obesity prevention. CI - (c) Madhumitha Ayyappan, Nowel Tan, Sarithra Jayasekaran, Chee Wai Ku, Chengsi Ong, Chua Mei Chien, Jerry Kok Yen Chan, Fabian Yap, See Ling Loy, Daniel Chan. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org). FAU - Ayyappan, Madhumitha AU - Ayyappan M AUID- ORCID: 0009-0006-7474-3028 AD - Duke-NUS Medical School, 8 College Rd, Singapore, 169857, Singapore, 65 93871908. FAU - Tan, Nowel AU - Tan N AUID- ORCID: 0009-0004-3894-344X AD - Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Jayasekaran, Sarithra AU - Jayasekaran S AUID- ORCID: 0009-0007-9889-1639 AD - Endocrinology Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Ku, Chee Wai AU - Ku CW AUID- ORCID: 0000-0003-3719-3005 AD - Duke-NUS Medical School, 8 College Rd, Singapore, 169857, Singapore, 65 93871908. AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Ong, Chengsi AU - Ong C AUID- ORCID: 0000-0002-5093-2848 AD - Duke-NUS Medical School, 8 College Rd, Singapore, 169857, Singapore, 65 93871908. AD - Department of Nutrition and Dietetics, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Mei Chien, Chua AU - Mei Chien C AUID- ORCID: 0000-0002-7471-751X AD - Duke-NUS Medical School, 8 College Rd, Singapore, 169857, Singapore, 65 93871908. AD - Department of Neonatology, KK Women's and Children's Hospital, Singapore, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. FAU - Chan, Jerry Kok Yen AU - Chan JKY AUID- ORCID: 0000-0002-0246-2159 AD - Duke-NUS Medical School, 8 College Rd, Singapore, 169857, Singapore, 65 93871908. AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Yap, Fabian AU - Yap F AUID- ORCID: 0000-0003-1083-7958 AD - Duke-NUS Medical School, 8 College Rd, Singapore, 169857, Singapore, 65 93871908. AD - Endocrinology Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. FAU - Loy, See Ling AU - Loy SL AUID- ORCID: 0000-0002-9205-5580 AD - Duke-NUS Medical School, 8 College Rd, Singapore, 169857, Singapore, 65 93871908. AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, Singapore. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Chan, Daniel AU - Chan D AUID- ORCID: 0000-0001-8191-5330 AD - Duke-NUS Medical School, 8 College Rd, Singapore, 169857, Singapore, 65 93871908. AD - Endocrinology Service, Department of Paediatrics, KK Women's and Children's Hospital, Singapore, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. LA - eng PT - Journal Article DEP - 20260511 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC13160257 OTO - NOTNLM OT - acceptability OT - childhood obesity OT - early-life behaviors OT - infant feeding OT - mHealth OT - mobile apps OT - mobile health OT - obesity prevention OT - usability COIS- Conflicts of Interest: None declared. EDAT- 2026/05/11 18:32 MHDA- 2026/05/11 18:33 PMCR- 2026/05/11 CRDT- 2026/05/11 14:52 PHST- 2025/10/19 00:00 [received] PHST- 2026/04/11 00:00 [revised] PHST- 2026/04/13 00:00 [accepted] PHST- 2026/05/11 18:33 [medline] PHST- 2026/05/11 18:32 [pubmed] PHST- 2026/05/11 14:52 [entrez] PHST- 2026/05/11 00:00 [pmc-release] AID - v9i1e86139 [pii] AID - 86139 [pii] AID - 10.2196/86139 [doi] PST - epublish SO - JMIR Pediatr Parent. 2026 May 11;9:e86139. doi: 10.2196/86139. PMID- 42113776 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260902 IS - 1365-2060 (Electronic) IS - 0785-3890 (Print) IS - 0785-3890 (Linking) VI - 58 IP - 1 DP - 2026 Dec TI - Knowledge, attitudes, and practices regarding vitamin D among university students in Quzhou, China: a cross-sectional study. PG - 2665503 LID - 10.1080/07853890.2026.2665503 [doi] LID - 2665503 AB - BACKGROUND: Vitamin D deficiency remains common in China, yet recent evidence on university students is limited. METHODS: We conducted a cross-sectional online survey among 397 undergraduates at Quzhou University from November to December 2025 using convenience sampling. A validated questionnaire assessed vitamin D knowledge, attitudes, and practices (KAP) with pre-specified adequacy thresholds (knowledge >/=6/11; attitude >/=3/5; practice >/=4/7). Associations with good practice were examined using logistic regression; item-level subgroup contrasts were explored by sex, attitude, and monthly pocket money. RESULTS: Awareness of vitamin D, defined as prior recognition of vitamin D, was universal (100%). Only 58.4% (232/397) had adequate knowledge; 66.8% (265/397) had a positive attitude; and 69.5% (276/397) achieved good practice. In multivariable models, women had lower odds of good practice than men (OR 0.57, 95% CI 0.35-0.90); monthly pocket money >/=2000 RMB was associated with higher odds of good practice (OR 3.74, 95% CI 1.70-8.24); and a positive attitude was independently associated with good practice (OR 3.02, 95% CI 1.91-4.79). Knowledge adequacy was not independently associated with practice. Item-level gaps clustered in sun-related behaviors (less daily outdoor walking, <15 min/day exposure, and sun-protection factor use), particularly among women, students with non-positive attitudes, and those with lower pocket money. CONCLUSION: Vitamin D KAP was suboptimal in this single-university sample in China. Practice was associated with sex, attitude, and economic means, but not knowledge adequacy alone. Future practice-oriented strategies may prioritize safe sun exposure, affordable supplementation, and on-campus testing for women, economically disadvantaged students, and students with non-positive attitudes. FAU - Wang, Jian AU - Wang J AD - Department of Gastroenterology, Jiaxing Second Hospital, Jiaxing, Zhejiang, China. FAU - Xu, Yanwen AU - Xu Y AD - Department of Neurology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, China. FAU - Wang, Weiguo AU - Wang W AD - Department of Gastroenterology, Jiaxing Second Hospital, Jiaxing, Zhejiang, China. FAU - Ma, Cuifang AU - Ma C AD - Department of Infectious Diseases, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260511 PL - England TA - Ann Med JT - Annals of medicine JID - 8906388 RN - 1406-16-2 (Vitamin D) SB - IM MH - Humans MH - Female MH - *Health Knowledge, Attitudes, Practice MH - Male MH - Cross-Sectional Studies MH - China/epidemiology MH - *Students/statistics & numerical data/psychology MH - *Vitamin D Deficiency/epidemiology/prevention & control/psychology MH - *Vitamin D/administration & dosage MH - Young Adult MH - Universities MH - Surveys and Questionnaires MH - Adult MH - Adolescent MH - Sex Factors PMC - PMC13162561 OTO - NOTNLM OT - Attitudes OT - awareness OT - knowledge OT - practices OT - students OT - vitamin D COIS- This study was approved by the Ethics Committee of Quzhou People's Hospital (Approval No. 2025-134). The requirement for written (signed) informed consent was waived by the Ethics Committee due to the anonymous, minimal-risk online survey design; consent was indicated by participants' decision to proceed with the questionnaire after reading the study information. EDAT- 2026/05/11 18:33 MHDA- 2026/05/11 18:34 PMCR- 2026/05/11 CRDT- 2026/05/11 13:33 PHST- 2026/05/11 18:34 [medline] PHST- 2026/05/11 18:33 [pubmed] PHST- 2026/05/11 13:33 [entrez] PHST- 2026/05/11 00:00 [pmc-release] AID - 2665503 [pii] AID - 10.1080/07853890.2026.2665503 [doi] PST - ppublish SO - Ann Med. 2026 Dec;58(1):2665503. doi: 10.1080/07853890.2026.2665503. Epub 2026 May 11. PMID- 42112945 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 2204-2091 (Electronic) IS - 2204-2091 (Linking) VI - 36 IP - 2 DP - 2026 Jun 25 TI - To what extent is air pollution associated with cardiorespiratory hospitalisations across Australia? A whole-of-population ecological study. LID - PU25054 [pii] LID - 10.1071/PU25054 [doi] AB - OBJECTIVES AND IMPORTANCE OF STUDY: This study aimed to examine the extent to which residential ambient air pollution across Australia, globally a relatively low-pollution setting, is associated with cardiovascular and respiratory hospitalisations. STUDY TYPE: A national, cross-sectional, ecological study. METHODS: This whole-of-population study used national air pollution estimates from 2016 and administrative hospitalisation data aggregated across 1155 public health areas from 2016 to 2017, representing 23,236,046 of the Australian population. Population-weighted median concentrations from 2016 of particulate matter 0.08 with sFLRV < mFLRV (Group A) remained associated with PHLF (OR 2.54, 95% CI 1.41-4.57). Delta alone had limited discrimination, but performance improved when combined with liver function variables in a multivariable model. CONCLUSIONS: A locally calibrated STLV equation reduces bias in volume standardization. Discordance where standardized FLRV is lower than measured FLRV is associated with higher PHLF risk after major hepatectomy and may refine preoperative risk stratification alongside functional markers. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Ding, Shijie AU - Ding S AD - General surgery, Cancer Center, Department of Hepatobiliary& Pancreatic Surgery and Minimally Invasive Surgery, Zhe Jiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, zhejiang, China; Department of Postgraduate Training, Base Alliance of Wenzhou Medical University, Wenzhou, Zhejiang, China. FAU - Tong, Haihang AU - Tong H AD - General surgery, Cancer Center, Department of Hepatobiliary& Pancreatic Surgery and Minimally Invasive Surgery, Zhe Jiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, zhejiang, China; Department of the Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. FAU - Xu, Zhenghao AU - Xu Z AD - General surgery, Cancer Center, Department of Hepatobiliary& Pancreatic Surgery and Minimally Invasive Surgery, Zhe Jiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, zhejiang, China; Department of the Second School of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. FAU - Gao, Yu-Lin AU - Gao YL AD - Hangzhou Dehetang Sanshentai Traditional Chinese Medicine Clinic, Hangzhou, China. FAU - Jin, Liming AU - Jin L AD - General surgery, Cancer Center, Department of Hepatobiliary& Pancreatic Surgery and Minimally Invasive Surgery, Zhe Jiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, zhejiang, China. FAU - Shen, Guo-Liang AU - Shen GL AD - General surgery, Cancer Center, Department of Hepatobiliary& Pancreatic Surgery and Minimally Invasive Surgery, Zhe Jiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, zhejiang, China. FAU - Liu, Junwei AU - Liu J AD - General surgery, Cancer Center, Department of Hepatobiliary& Pancreatic Surgery and Minimally Invasive Surgery, Zhe Jiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, zhejiang, China. FAU - Huang, Jing AU - Huang J AD - Department of Hepatopancreatobiliary Surgery, The Affiliated Lihuili Hospital of Ningbo University, Ningbo University, Ningbo, Zhejiang, China. FAU - Yao, Weifeng AU - Yao W AD - General surgery, Cancer Center, Department of Hepatobiliary& Pancreatic Surgery and Minimally Invasive Surgery, Zhe Jiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, zhejiang, China; Department of Hepatobiliary & Pancreatic Surgery, Zhejiang Provincial People's Hospital Bijie Hospital, Bijie, Guizhou, China. Electronic address: joe2118@126.com. FAU - Xiao, Zun-Qiang AU - Xiao ZQ AD - General surgery, Cancer Center, Department of Hepatobiliary& Pancreatic Surgery and Minimally Invasive Surgery, Zhe Jiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, zhejiang, China. Electronic address: zqxiao@zcmu.edu.cn. LA - eng PT - Journal Article DEP - 20260505 PL - England TA - Eur J Surg Oncol JT - European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology JID - 8504356 SB - IM MH - Humans MH - *Hepatectomy/adverse effects MH - *Liver Failure/etiology/epidemiology MH - Retrospective Studies MH - Female MH - Male MH - Organ Size MH - *Liver Neoplasms/surgery MH - *Postoperative Complications/etiology MH - Middle Aged MH - Magnetic Resonance Imaging MH - Tomography, X-Ray Computed MH - *Liver/diagnostic imaging/pathology MH - China MH - Aged OTO - NOTNLM OT - Future liver remnant OT - Liver volumetry OT - Major hepatectomy OT - Posthepatectomy liver failure OT - Volumetric discordance COIS- Declaration of interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/11 00:30 MHDA- 2026/06/15 11:30 CRDT- 2026/05/10 18:03 PHST- 2026/03/15 00:00 [received] PHST- 2026/05/03 00:00 [revised] PHST- 2026/05/04 00:00 [accepted] PHST- 2026/06/15 11:30 [medline] PHST- 2026/05/11 00:30 [pubmed] PHST- 2026/05/10 18:03 [entrez] AID - S0748-7983(26)00475-0 [pii] AID - 10.1016/j.ejso.2026.111856 [doi] PST - ppublish SO - Eur J Surg Oncol. 2026 Jul;52(7):111856. doi: 10.1016/j.ejso.2026.111856. Epub 2026 May 5. PMID- 42106166 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1365-2834 (Electronic) IS - 0966-0429 (Print) IS - 0966-0429 (Linking) VI - 2026 IP - 1 DP - 2026 TI - Factors Influencing ICU Nurses' Proficiency in Point-of-Care Gastrointestinal Ultrasound: A National Cross-Sectional Study. PG - e3178958 LID - 10.1155/jonm/3178958 [doi] LID - 3178958 AB - AIMS: To evaluate point-of-care gastrointestinal ultrasound (GI-POCUS) proficiency, identify influencing factors, and examine its clinical application among intensive care unit (ICU) nurses in China. BACKGROUND: GI-POCUS supports gastrointestinal function assessment, enteral nutrition guidance, and dysfunction detection in patients who are critically ill. However, its use among ICU nurses remains limited, and the factors influencing proficiency are unclear. METHODS: A national cross-sectional survey was conducted among 2009 ICU nurses from 21 provinces in China using a structured online questionnaire covering their demographic and unit characteristics, GI-POCUS training, practice, skills, proficiency, and clinical application. Participants were recruited from various ICU settings, with the majority from adult ICUs and a small proportion from pediatric and neonatal ICUs. Data were analyzed using SPSS 27.0 with descriptive statistics, chi-square tests, t-tests, and multivariate logistic regression. RESULTS: Only 297/2009 (14.8%) of ICU nurses rated their GI-POCUS proficiency as "good," whereas 1205/2009 (59.9%) rated it as "poor." GI-POCUS proficiency was significantly associated with billability, training participation, usage frequency, documentation of GI-POCUS findings in nursing charts, proficiency in probe operations, ability to perform qualitative and quantitative analyses, and diagnostic accuracy and sensitivity (p < 0.05). Clinically, only 492/2009 (24.5%) of ICU nurses could identify intestinal necrosis or ischemia. 1232/2009 (61.3%) applied GI-POCUS to assess gastric emptying and residual volume, and 1069/2009 (53.2%) used it to guide feeding tube placement. 1032/2009 (51.4%) of ICU nurses could identify gastric transverse and longitudinal section images, whereas the recognition rate for intestinal wall blood flow signals was the lowest at only 369/2009 (18.4%). CONCLUSION: GI-POCUS proficiency among ICU nurses in China is low. Promoting sustainable implementation requires organizational support, leadership engagement, and integration into routine critical care nursing practice. IMPLICATIONS FOR LEADERS: Nursing leaders should establish structured GI-POCUS training pathways, integrate ultrasound use into routine ICU workflows and electronic documentation systems, and advocate for institutional recognition including billing mechanisms. These leadership actions can enhance nurses' proficiency and promote sustainable nurse-led GI-POCUS implementation. CI - Copyright (c) 2026 Gang Wang et al. Journal of Nursing Management published by John Wiley & Sons Ltd. FAU - Wang, Gang AU - Wang G AD - Department of Critical Care Medicine, Affiliated Hospital of Qingdao University, Qingdao, China, qdu.edu.cn. FAU - Liu, Yingying AU - Liu Y AUID- ORCID: 0009-0000-4073-0567 AD - Department of Critical Care Medicine, Affiliated Hospital of Qingdao University, Qingdao, China, qdu.edu.cn. FAU - Wang, Shengyun AU - Wang S AD - Organizational Management Department, Shandong Provincial Nursing Association, Jinan, China. FAU - Gao, Silong AU - Gao S AD - Department of Critical Care Medicine, Affiliated Hospital of Qingdao University, Qingdao, China, qdu.edu.cn. FAU - Lin, Hui AU - Lin H AD - Liver Disease Center Intensive Care Unit, Affiliated Hospital of Qingdao University, Qingdao, China, qdu.edu.cn. FAU - Wu, Qian AU - Wu Q AD - Department of Neonatal, Affiliated Hospital of Qingdao University, Qingdao, China, qdu.edu.cn. FAU - Huang, Debin AU - Huang D AD - Department of Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China, gxmu.edu.cn. FAU - Pan, Yueshuai AU - Pan Y AUID- ORCID: 0000-0002-9157-3765 AD - Department of Nursing, Affiliated Hospital of Qingdao University, Qingdao, China, qdu.edu.cn. FAU - Zhao, Yuxiao AU - Zhao Y AD - Department of Critical Care Medicine, Affiliated Hospital of Qingdao University, Qingdao, China, qdu.edu.cn. FAU - Wei, Huimin AU - Wei H AUID- ORCID: 0009-0001-2149-3719 AD - Department of Critical Care Medicine, Affiliated Hospital of Qingdao University, Qingdao, China, qdu.edu.cn. FAU - Wei, Lili AU - Wei L AUID- ORCID: 0000-0003-2891-5889 AD - Office of Dean, Affiliated Hospital of Qingdao University, Qingdao, China, qdu.edu.cn. LA - eng PT - Journal Article PL - England TA - J Nurs Manag JT - Journal of nursing management JID - 9306050 SB - IM MH - Humans MH - Cross-Sectional Studies MH - China MH - *Point-of-Care Systems/standards MH - Ultrasonography/standards/methods MH - Intensive Care Units/organization & administration MH - Female MH - *Clinical Competence/standards/statistics & numerical data MH - Surveys and Questionnaires MH - Adult MH - Male MH - *Gastrointestinal Tract/diagnostic imaging PMC - PMC13157328 OTO - NOTNLM OT - cross-sectional study OT - gastrointestinal ultrasound OT - influencing factors OT - intensive care unit OT - nurses COIS- The authors declare no conflicts of interest. EDAT- 2026/05/10 05:18 MHDA- 2026/05/10 05:19 PMCR- 2026/05/09 CRDT- 2026/05/09 20:53 PHST- 2026/04/04 00:00 [revised] PHST- 2025/11/14 00:00 [received] PHST- 2026/04/07 00:00 [accepted] PHST- 2026/05/10 05:19 [medline] PHST- 2026/05/10 05:18 [pubmed] PHST- 2026/05/09 20:53 [entrez] PHST- 2026/05/09 00:00 [pmc-release] AID - JONM3178958 [pii] AID - 10.1155/jonm/3178958 [doi] PST - ppublish SO - J Nurs Manag. 2026;2026(1):e3178958. doi: 10.1155/jonm/3178958. PMID- 42105725 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260810 IS - 1879-2219 (Electronic) IS - 0966-6362 (Linking) VI - 128 DP - 2026 Jul TI - Wearable inertial sensors for paediatric gait assessment: A systematic review. PG - 110188 LID - S0966-6362(26)00098-6 [pii] LID - 10.1016/j.gaitpost.2026.110188 [doi] AB - BACKGROUND: Instrumented gait analysis is an important tool for evaluating ambulatory function in children with gait impairments, yet conventional laboratory-based systems require specialised facilities and personnel, limiting availability in some settings. Wearable inertial measurement units (IMUs) provide a practical means of capturing gait parameters in clinical and real-world environments. OBJECTIVES: To systematically review the literature on IMU-based gait assessment in children, with a focus on readiness for clinical implementation, examining sensor configurations, reported gait metrics, and experimental methodologies. METHODS: A systematic search of six databases (PubMed, EMBASE, Scopus, Web of Science, IEEE Xplore, CINAHL) was conducted to identify English-language studies assessing spatiotemporal, kinematic, or kinetic gait parameters using IMUs in children (<18 years) under typical walking conditions. Two reviewers independently screened studies, extracted data, and evaluated methodological quality using the AXIS tool. RESULTS: Forty-five studies met inclusion criteria. Twenty-eight involved children with gait-affecting conditions (e.g. cerebral palsy). Single-sensor lumbar setups were common for spatiotemporal assessment (e.g. stride-time, cadence and speed), while multi-sensor configurations enabled kinematic analysis. Thirteen studies validated IMU-derived metrics against optical motion capture or pressure-sensitive walkways. Spatiotemporal parameters often showed high agreement with reference standards. Sagittal-plane joint angles demonstrated moderate-to-high accuracy, with poorer accuracy in frontal and transverse planes. Agreement and reliability were lower in children with gait impairments than in typically developing cohorts. Reporting of setup and processing methods was often incomplete. CONCLUSION: IMUs demonstrate strong potential as accessible, cost-effective tools for paediatric gait assessment. Progress toward clinical translation requires standardised reporting, paediatric-focused algorithm development, and broader validation across ages and diagnoses. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Bavan, Luckshman AU - Bavan L AD - The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G1X8, Canada; Holland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, 150 Kilgour Road, Toronto, ON M4G 1R8, Canada; Department of Surgery, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address: luckshman.bavan@sickkids.ca. FAU - Ng, Kelvin AU - Ng K AD - Department of Surgery, University of Toronto, Toronto, ON M5S 1A8, Canada. FAU - Gardner, Richard AU - Gardner R AD - The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G1X8, Canada; Holland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, 150 Kilgour Road, Toronto, ON M4G 1R8, Canada; Department of Surgery, University of Toronto, Toronto, ON M5S 1A8, Canada. FAU - Andrysek, Jan AU - Andrysek J AD - Holland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, 150 Kilgour Road, Toronto, ON M4G 1R8, Canada; Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto, ON M5S 3G9, Canada. FAU - Narayanan, Unni AU - Narayanan U AD - The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G1X8, Canada; Holland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, 150 Kilgour Road, Toronto, ON M4G 1R8, Canada; Department of Surgery, University of Toronto, Toronto, ON M5S 1A8, Canada. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260409 PL - England TA - Gait Posture JT - Gait & posture JID - 9416830 SB - IM MH - Humans MH - Child MH - *Gait Analysis/instrumentation MH - *Wearable Electronic Devices MH - Biomechanical Phenomena MH - *Gait/physiology MH - *Gait Disorders, Neurologic/diagnosis/physiopathology OTO - NOTNLM OT - Gait analysis OT - Inertial measurement units OT - Kinematics OT - Paediatric gait OT - Spatiotemporal parameters OT - Wearable sensors COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/10 05:19 MHDA- 2026/05/16 00:37 CRDT- 2026/05/09 18:11 PHST- 2025/11/23 00:00 [received] PHST- 2026/02/25 00:00 [revised] PHST- 2026/04/07 00:00 [accepted] PHST- 2026/05/16 00:37 [medline] PHST- 2026/05/10 05:19 [pubmed] PHST- 2026/05/09 18:11 [entrez] AID - S0966-6362(26)00098-6 [pii] AID - 10.1016/j.gaitpost.2026.110188 [doi] PST - ppublish SO - Gait Posture. 2026 Jul;128:110188. doi: 10.1016/j.gaitpost.2026.110188. Epub 2026 Apr 9. PMID- 42104686 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1742-7843 (Electronic) IS - 1742-7835 (Print) IS - 1742-7835 (Linking) VI - 138 IP - 6 DP - 2026 Jun TI - Maternal Dyslipidaemia Aggravates Offspring Metabolic Dysfunction-Associated Steatotic Liver Disease. PG - e70235 LID - 10.1111/bcpt.70235 [doi] LID - e70235 AB - Paediatric metabolic dysfunction-associated steatotic liver disease (MASLD) and steatohepatitis (MASH) display a distinct and severe histopathology. Maternal metabolic status may program offspring susceptibility to MASLD. This study investigated if maternal dyslipidaemia and low vitamin C (VitC) status influence offspring MASLD using a validated guinea pig model. Thirty female guinea pigs received a low-fat (LF) diet until pregnancy was confirmed, then remained on LF or switched to a high-fat (HF) diet with or without reduced VitC. Offspring were evaluated at birth and after 10 weeks on postweaning HF or LF diets. In dams, HF diet induced dyslipidaemia and elevated hepatic triglycerides and alanine aminotransferase (ALT) compared to LF dams, without causing obesity. Newborns exposed to maternal HF diet showed increased hepatic triglycerides, liver-to-body weight ratio and ALT. By 10 weeks, liver fibrosis and MASLD activity scores were higher in offspring maintained on a postnatal HF diet compared to LF. Notably, offspring viability was markedly reduced on maternal HF diet with low VitC. These findings demonstrate that even short exposure to maternal HF diet, independent of obesity, can adversely affect offspring MASLD risk and highlight the need for early prevention. Additionally, findings support the need to investigate interactions between maternal diet, VitC status and offspring survival. CI - (c) 2026 The Author(s). Basic & Clinical Pharmacology & Toxicology published by John Wiley & Sons Ltd on behalf of Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society). FAU - Pedersen, Kamilla AU - Pedersen K AUID- ORCID: 0000-0003-2852-2882 AD - Section of Biomedicine, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark. FAU - Buhl, Sanne Fredslund AU - Buhl SF AD - Section of Biomedicine, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark. FAU - Hojgaard-Jensen, Cecilie AU - Hojgaard-Jensen C AD - Section of Biomedicine, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark. FAU - Lykkesfeldt, Jens AU - Lykkesfeldt J AUID- ORCID: 0000-0002-6514-8407 AD - Section of Biomedicine, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark. FAU - Tveden-Nyborg, Pernille AU - Tveden-Nyborg P AUID- ORCID: 0000-0002-5574-5742 AD - Section of Biomedicine, Department of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg, Denmark. LA - eng GR - 1001109652/LifePharm Centre for In Vivo Pharmacology/ PT - Journal Article PL - England TA - Basic Clin Pharmacol Toxicol JT - Basic & clinical pharmacology & toxicology JID - 101208422 RN - 0 (Triglycerides) RN - EC 2.6.1.2 (Alanine Transaminase) RN - PQ6CK8PD0R (Ascorbic Acid) SB - IM MH - Animals MH - Female MH - Guinea Pigs MH - Pregnancy MH - *Dyslipidemias/complications/metabolism MH - *Prenatal Exposure Delayed Effects MH - Diet, High-Fat/adverse effects MH - Liver/pathology/metabolism MH - *Fatty Liver/etiology MH - Disease Models, Animal MH - Developmental Origins of Health and Disease MH - *Ascorbic Acid Deficiency/complications MH - Triglycerides/metabolism MH - Diet, Fat-Restricted/adverse effects MH - Alanine Transaminase/metabolism MH - *Non-alcoholic Fatty Liver Disease/etiology MH - Maternal Nutritional Physiological Phenomena MH - Animals, Newborn MH - Ascorbic Acid PMC - PMC13156527 OAB - This study investigated if a mother's diet during pregnancy affects her offspring's risk of developing fatty liver disease. Using guinea pigs, which develop fatty liver disease in ways very similar to humans, we showed that a maternal high-fat diet for the second half of pregnancy led to increased liver fat and injury in newborns. When these offspring continued on a high-fat diet after weaning, they developed worse liver disease than those not exposed during pregnancy. Our results suggest that even without maternal obesity, an unhealthy diet during pregnancy may increase the risk of liver disease in offspring. OABL- eng OTO - NOTNLM OT - developmental origins of disease OT - dyslipidaemia OT - guinea pigs OT - steatohepatitis OT - vitamin C COIS- The LifePharm Centre for In Vivo Pharmacology is partly funded by Novo Nordisk, a pharmaceutical company developing treatments for MASLD/MASH. The company was not involved in study design, data collection, analysis, interpretation, manuscript preparation or the decision to publish. EDAT- 2026/05/09 06:33 MHDA- 2026/05/09 06:34 PMCR- 2026/05/09 CRDT- 2026/05/09 02:44 PHST- 2026/03/27 00:00 [revised] PHST- 2025/12/16 00:00 [received] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/05/09 06:34 [medline] PHST- 2026/05/09 06:33 [pubmed] PHST- 2026/05/09 02:44 [entrez] PHST- 2026/05/09 00:00 [pmc-release] AID - BCPT70235 [pii] AID - 10.1111/bcpt.70235 [doi] PST - ppublish SO - Basic Clin Pharmacol Toxicol. 2026 Jun;138(6):e70235. doi: 10.1111/bcpt.70235. PMID- 42104484 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260509 LR - 20260813 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2026 May 8 TI - Validation of the German Child Eating Behaviour Questionnaire (CEBQ) in children and adolescents with eating disorders and ADHD. LID - 10.1186/s40337-026-01589-8 [doi] LID - 108 AB - BACKGROUND: The Child Eating Behaviour Questionnaire (CEBQ) is an internationally applied, parent-report questionnaire on children's eating behaviors, but has mainly been validated in population-based samples or children with obesity. This study presents a first comprehensive validation of the German version of the CEBQ in a treatment-seeking and community-based sample including anorexia nervosa (AN), avoidant-restrictive food intake disorder (ARFID), loss of control (LOC) eating, attention-deficit/hyperactivity disorder (ADHD), and a healthy control group. METHODS: The German version of the CEBQ was completed by 226 parents of children and adolescents (9 months to 17 years) in Germany and Switzerland. Factorial, convergent, and discriminant validity, internal consistency, as well as sociodemographic correlates were assessed, using objectively measured anthropometrics and well-established clinical interviews and questionnaires on eating disorders and associated psychopathology in parent- and self-report. RESULTS: The original 8-factor structure showed acceptable model fit and acceptable to excellent internal consistency. Convergent validity was mostly supported by weight status and interview- and questionnaire-measured eating behaviors. The CEBQ subscales differentiated between groups associated with overeating (ADHD, LOC eating) versus restrictive eating (ARFID and AN). CONCLUSION: The results support the German version of the CEBQ as a valid and reliable tool for assessing eating behavior in youth with eating disorders and ADHD. Future research using larger and age-specific samples should examine psychometric comparability across developmental stages and may provide norms for the CEBQ to enhance its utility as a screening tool. CI - (c) 2026. The Author(s). FAU - Ulbrich, Julia AU - Ulbrich J AUID- ORCID: 0009-0008-2949-6675 AD - Department of Psychosomatic Medicine and Psychotherapy, Behavioral Medicine Research Unit, Integrated Research and Treatment Center AdiposityDiseases, Leipzig University Medical Center, Philipp-Rosenthal- Strasse 55, 04103, Leipzig, Germany. julia.ulbrich@medizin.uni-leipzig.de. FAU - Hilbert, Anja AU - Hilbert A AUID- ORCID: 0000-0003-2775-1296 AD - Department of Psychosomatic Medicine and Psychotherapy, Behavioral Medicine Research Unit, Integrated Research and Treatment Center AdiposityDiseases, Leipzig University Medical Center, Philipp-Rosenthal- Strasse 55, 04103, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), partner site Leipzig/Dresden, Leipzig, Germany. FAU - Munsch, Simone AU - Munsch S AUID- ORCID: 0000-0002-6187-8912 AD - Department of Psychology, Clinical Psychology and Psychotherapy, University of Fribourg, Fribourg, Switzerland. AD - Food Research and Innovation Center, Cluster Food and Mental Health/Psychology, University of Fribourg, Fribourg, Switzerland. FAU - Schmidt, Ricarda AU - Schmidt R AUID- ORCID: 0000-0001-7794-2897 AD - Department of Psychosomatic Medicine and Psychotherapy, Behavioral Medicine Research Unit, Integrated Research and Treatment Center AdiposityDiseases, Leipzig University Medical Center, Philipp-Rosenthal- Strasse 55, 04103, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), partner site Leipzig/Dresden, Leipzig, Germany. LA - eng PT - Journal Article DEP - 20260508 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC13156854 OAB - The Child Eating Behaviour Questionnaire (CEBQ) is an internationally used questionnaire completed by parents to describe different eating behaviors in children. This study tested whether the German version of the questionnaire is suitable not only for healthy children or children with obesity, as shown previously, but also for children and adolescents with eating disorders or eating difficulties, such as anorexia nervosa (AN), avoidant-restrictive food intake disorder (ARFID), loss of control (LOC) eating, and attention-deficit/hyperactivity disorder (ADHD). A total of 226 parents of children and adolescents in Germany and Switzerland completed the questionnaire. The results, as expected, showed that the questionnaire measured eight aspects of eating behavior in a reliable and consistent way. The parents' answers corresponded well with the children's weight and information from clinical interviews and conceptually related questionnaires. The CEBQ also revealed differences between groups of children or adolescents who tend to overeat (ADHD, LOC eating) compared to those who restrict their eating (ARFID and AN). Overall, the findings provide support for the German CEBQ as a useful tool for assessing eating behaviors in youth across clinical groups, including eating disorders and ADHD. OABL- eng OTO - NOTNLM OT - ADHD OT - Assessment OT - Child eating behavior questionnaire (CEBQ) OT - Eating disorders OT - Factor analysis OT - Psychometric properties OT - Validation COIS- Declarations. Ethics approval and consent to participate: The studies were approved by the local Ethics Committees (Leipzig, Germany/ Fribourg, Switzerland), and informed consent and assent was provided by parents and children >/= 8 years old. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/09 00:34 MHDA- 2026/05/09 00:35 PMCR- 2026/05/08 CRDT- 2026/05/08 23:54 PHST- 2025/10/29 00:00 [received] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/05/09 00:35 [medline] PHST- 2026/05/09 00:34 [pubmed] PHST- 2026/05/08 23:54 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - 10.1186/s40337-026-01589-8 [pii] AID - 1589 [pii] AID - 10.1186/s40337-026-01589-8 [doi] PST - epublish SO - J Eat Disord. 2026 May 8;14(1):108. doi: 10.1186/s40337-026-01589-8. PMID- 42104437 OWN - NLM STAT- MEDLINE DCOM- 20260702 LR - 20260813 IS - 1868-7083 (Electronic) IS - 1868-7075 (Print) IS - 1868-7075 (Linking) VI - 18 IP - 1 DP - 2026 May 8 TI - Body mass index, physical activity, and epigenetic aging: a cross-population study. LID - 10.1186/s13148-026-02149-2 [doi] LID - 127 AB - BACKGROUND: Observational studies have suggested that body mass index (BMI) is associated with accelerated epigenetic aging; however, the age at which this association begins and the duration of its effects have not been fully established. This study evaluated the effects of BMI and physical activity on epigenetic aging from early life to adulthood. METHODS: We integrated multi-source data from populations of different racial backgrounds, including genome-wide association study (GWAS) data, the National Health and Nutrition Examination Survey (NHANES), clinical visceral adipose tissue, and blood samples from obese and physically active populations. Specifically, Mendelian randomization (MR) analysis was used to infer the causal relationship between early-life BMI and epigenetic age acceleration and to identify potential mediators. NHANES data were then analyzed to validate this association at the population level. Finally, biomarkers in blood and adipose tissue were examined to assess whether physical activity is associated with reduced aging-related signatures. RESULTS: The Mendelian randomization analyses indicated that high early-life BMI was causally associated with accelerated epigenetic aging across multiple epigenetic clocks, with beta ranging from 0.231 to 0.506; similar associations were also observed for childhood obesity, with beta ranging from 0.139 to 0.231. Physical activity was identified as an important mediator that attenuated epigenetic aging acceleration, with mediation effects accounting for 10.70% to 16.22%. Analysis of the NHANES dataset further confirmed that epigenetic age acceleration increases progressively with increasing BMI: [25 /= 40: beta = 4.64, 95% CI (4.30, 4.99)]. Subgroup analysis showed that, at the same BMI level, female exhibited more severe PhenoAA acceleration than male. Validation using multi-tissue samples showed that obesity accelerates DNA damage and significantly upregulates genes involved in cell cycle regulation. Physical activity significantly inhibited the upregulation of aging-related genes and reduced oxidative stress. CONCLUSION: BMI is strongly associated with accelerated epigenetic aging. This association is evident in children with obesity, becomes stronger with higher BMI, and is also observed in adults, whereas physical activity may partially attenuate this process. Trial registration Name of the registry: China-Japan Friendship Hospital National Integrated Chinese and Western Medicine Medical Center. Unique identifying number or registration ID: NCT06452303. Hyperlink to your specific registration (must be publicly accessible and will be checked): https://www.centerwatch.com/clinical-trials/listings/NCT06452303/the-patient-cohort-for-bariatric-surgery . CI - (c) 2026. The Author(s). FAU - Zhou, Bojun AU - Zhou B AD - Department of Exercise Physiology, Beijing Sport University, Beijing, 100091, Beijing, China. AD - Department of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, 100029, Beijing, China. FAU - Wu, Dongzhe AU - Wu D AD - Department of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, 100029, Beijing, China. FAU - Chen, Shuting AU - Chen S AD - Department of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, 100029, Beijing, China. AD - School of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, 100091, Beijing, China. FAU - Zhang, Shiyan AU - Zhang S AD - Department of Exercise Physiology, Beijing Sport University, Beijing, 100091, Beijing, China. AD - Department of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, 100029, Beijing, China. FAU - Ge, Xiaochuan AU - Ge X AD - Department of Exercise Physiology, Beijing Sport University, Beijing, 100091, Beijing, China. AD - Department of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, 100029, Beijing, China. FAU - Li, Jiaming AU - Li J AD - Department of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, 100029, Beijing, China. FAU - Zhu, Lianghao AU - Zhu L AD - Key Laboratory of Competitive Sport Psychological and Psychological Regulation, Tianjin University of Sport, Tianjin, 300211, Tianjin, China. FAU - Zhou, Shijie AU - Zhou S AD - School of Laboratory Medicine and School of Biological Engineering, Hangzhou Medical College, Zhejiang, 310059, Hangzhou, China. FAU - Chang, Ninghao AU - Chang N AD - The High School Affiliated to Beijing Normal University, Beijing, 100051, Beijing, China. FAU - Zhou, Biao AU - Zhou B AD - Department of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, 100029, Beijing, China. zhoubiao327@163.com. FAU - Zhang, Lei AU - Zhang L AD - Department of Oncology, Sinopharm Tongmei General Hospital, Shanxi, 037000, Datong, China. zhanglei412625@163.com. FAU - Meng, Hua AU - Meng H AD - Department of General Surgery and Obesity and Metabolic Disease Center, China-Japan Friendship Hospital, Beijing, 100029, Beijing, China. menghuade@hotmail.com. LA - eng SI - ClinicalTrials.gov/NCT06452303 GR - 82470857/National Natural Science Foundation of China/ GR - 7242125/Beijing Natural Science Foundation/ PT - Journal Article PT - Observational Study DEP - 20260508 PL - Germany TA - Clin Epigenetics JT - Clinical epigenetics JID - 101516977 SB - IM MH - Adult MH - Child MH - Female MH - Humans MH - Male MH - Middle Aged MH - *Aging/genetics MH - *Body Mass Index MH - DNA Methylation MH - *Epigenesis, Genetic MH - *Exercise/physiology MH - Genome-Wide Association Study/methods MH - Mendelian Randomization Analysis/methods MH - Nutrition Surveys MH - Obesity/genetics PMC - PMC13326471 OTO - NOTNLM OT - Aging clock OT - Body mass index OT - Epigenetics OT - Physical activity COIS- Declarations. Ethics approval and consent to participate: All the cohorts and samples involved in the study adhered to national and international guidelines, including the Deontological Code and the Declaration of Helsinki, and complied with current personal data protection regulations. The research using publicly available data was approved by the relevant authorities, with all participants having provided informed consent. For the multi-biomarker studies, ethical approval was obtained from China-Japan Friendship Hospital and Beijing Sport University, and all participants signed informed consent forms (Ethics approval number: 2021-112-K70). Consent for publication: Written informed consent for publication was obtained from every patient; for minors, consent was secured from their parents or legal guardians. Competing interests: The authors declare no competing interests. EDAT- 2026/05/09 00:33 MHDA- 2026/07/02 06:40 PMCR- 2026/05/08 CRDT- 2026/05/08 23:52 PHST- 2026/01/24 00:00 [received] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/07/02 06:40 [medline] PHST- 2026/05/09 00:33 [pubmed] PHST- 2026/05/08 23:52 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - 10.1186/s13148-026-02149-2 [pii] AID - 2149 [pii] AID - 10.1186/s13148-026-02149-2 [doi] PST - epublish SO - Clin Epigenetics. 2026 May 8;18(1):127. doi: 10.1186/s13148-026-02149-2. PMID- 42103989 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 6 DP - 2026 May 8 TI - Pediatric continuous reference intervals of coronary artery diameter by echocardiography in healthy Chinese children population. LID - 373 [pii] LID - 10.1007/s00431-026-07012-3 [doi] AB - The aim of this study was to establish body surface area (BSA)-dependent Z-score continuous reference intervals of coronary artery diameter measured by Echocardiography in healthy Chinese children population. Echocardiography measured 1221 healthy Chinese children's coronary artery diameters, including the LMCA, LAD, LCX, RCA-pro, RCA-mid, and RCA-dis. We employed the LMS (Lambda-Mu-Sigma) method for the model and the Haycock equation for the BSA estimation. The coronary artery diameter Z-score continuous reference intervals were established using the LMS method and passed the internal and external validation. CONCLUSIONS: The study outcome provides BSA-dependent Z-score continuous reference intervals for the coronary artery diameters in healthy Chinese children. There is a web Z-score calculator with convenient application for clinicians and ultrasound doctors, facilitating subsequent external validations in a larger population. WHAT IS KNOWN: * Echocardiography is the primary non‑invasive modality for assessing coronary artery (CA) diameter in children, and body surface area (BSA)‑dependent Z‑scores provide a more objective evaluation than absolute values. * The LMS (Lambda‑Mu‑Sigma) method is an internationally accepted approach for establishing continuous reference intervals, as used in the WHO child growth standards. WHAT IS NEW: * This study establishes BSA‑dependent Z‑score continuous reference intervals for six coronary artery segments (LMCA, LAD, LCX, RCA‑pro, RCA‑mid, RCA‑dis) specifically in healthy Chinese children aged 0 days to 18 years. * It provides a validated, LMS‑based model along with an online Z‑score calculator and a fully reproducible computational procedure, addressing the lack of updated, ethnicity‑specific continuous reference intervals for the Chinese pediatric population. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Zheng, Lin AU - Zheng L AD - Department of Echocardiography, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. FAU - Peng, Ya-Guang AU - Peng YG AD - Center for Clinical Epidemiology and Evidence-Based Medicine, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. FAU - Yang, Jiao AU - Yang J AD - Department of Echocardiography, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. FAU - Li, Jing-Ya AU - Li JY AD - Department of Echocardiography, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. FAU - Zhang, Xin AU - Zhang X AD - Department of Echocardiography, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. FAU - Sun, Yan AU - Sun Y AD - Department of Echocardiography, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. FAU - Liu, Guo-Wen AU - Liu GW AD - Department of Echocardiography, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. FAU - Ma, Ning AU - Ma N AD - Department of Echocardiography, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, 100045, China. echo_mn@163.com. LA - eng PT - Journal Article DEP - 20260508 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - Chinese people SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Body Surface Area MH - China MH - *Coronary Vessels/diagnostic imaging/anatomy & histology MH - *Echocardiography/methods MH - Reference Values MH - East Asian People OTO - NOTNLM OT - Z-score OT - Continuous reference intervals OT - Coronary artery OT - KD OT - LMS method COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/05/09 00:33 MHDA- 2026/05/09 00:34 CRDT- 2026/05/08 23:22 PHST- 2025/11/27 00:00 [received] PHST- 2026/04/26 00:00 [accepted] PHST- 2026/04/12 00:00 [revised] PHST- 2026/05/09 00:34 [medline] PHST- 2026/05/09 00:33 [pubmed] PHST- 2026/05/08 23:22 [entrez] AID - 10.1007/s00431-026-07012-3 [pii] AID - 10.1007/s00431-026-07012-3 [doi] PST - epublish SO - Eur J Pediatr. 2026 May 8;185(6):373. doi: 10.1007/s00431-026-07012-3. PMID- 42102665 OWN - NLM STAT- MEDLINE DCOM- 20260527 LR - 20260528 IS - 1879-0739 (Electronic) IS - 0271-5317 (Linking) VI - 150 DP - 2026 Jun TI - Moderate coffee intake does not significantly affect short-term bioelectrical impedance measurements in healthy women. PG - 62-71 LID - S0271-5317(26)00041-2 [pii] LID - 10.1016/j.nutres.2026.04.002 [doi] AB - Bioelectrical impedance analysis (BIA) is a widely used, noninvasive method for assessing body composition. However, its sensitivity to acute changes in water consumption and coffee intake raises concerns about measurement reliability. This study hypothesized that the short-term consumption of 200 mL caffeinated or decaffeinated coffee would result in measurable changes in BIA-derived body composition parameters compared to water intake. Twenty-seven healthy female participants (aged 18-35 years; body mass index 18.5-29.9 kg/m(2)) were randomly assigned to one of three groups: caffeinated coffee, decaffeinated coffee, or water (n = 9 per group). After all groups consumed 200 mL of the assigned beverage, BIA measurements were performed at baseline, 30, 60, 90, and 120 minutes using the InBody 270 analyzer. Nonparametric tests (Kruskal-Wallis, Friedman) and Quade ANCOVA were applied to assess between- and within-group differences, adjusting for baseline values. Significant within-group changes were observed in body weight and body mass index across all groups (P < .05). Between-group differences emerged in fat mass, fat percentage, and body mass index at multiple time points (P < .05); however, none remained significant after adjusting for baseline using Quade ANCOVA (all P > .05). Notably, several parameters showed medium to large effect sizes, despite nonsignificant P values. Under controlled conditions, moderate caffeine intake ( approximately 95 to 100 mg) or 200 mL fluid volume does not induce significant short-term alterations in BIA-derived body composition in healthy women. Visual trends suggest transient fluctuations within the first 60 minutes, though these were not clinically meaningful. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Sabuncular, Guleren AU - Sabuncular G AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Marmara University, Maltepe, Istanbul, Turkiye. Electronic address: guleren.sabuncular@marmara.edu.tr. FAU - Agopyan, Ani AU - Agopyan A AD - Training and Movement Science, Department of Coaching Education, Faculty of Sport Sciences, Marmara University, Istanbul, Turkiye. FAU - Acikgoz, Ayse AU - Acikgoz A AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Marmara University, Maltepe, Istanbul, Turkiye. FAU - Karatay, Habibe Nur AU - Karatay HN AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Marmara University, Maltepe, Istanbul, Turkiye. FAU - Ali Ozturk, Muhammet AU - Ali Ozturk M AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Marmara University, Maltepe, Istanbul, Turkiye. FAU - Yildiz, Ruveyda Gulce AU - Yildiz RG AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Marmara University, Maltepe, Istanbul, Turkiye. FAU - Aktac, Sule AU - Aktac S AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Marmara University, Maltepe, Istanbul, Turkiye. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260413 PL - United States TA - Nutr Res JT - Nutrition research (New York, N.Y.) JID - 8303331 RN - 0 (Coffee) RN - 3G6A5W338E (Caffeine) SB - IM MH - Humans MH - Female MH - *Coffee/chemistry MH - Adult MH - *Electric Impedance MH - Young Adult MH - *Caffeine/pharmacology/administration & dosage MH - *Body Composition/drug effects MH - Adolescent MH - Body Mass Index MH - Drinking MH - Body Weight MH - Reproducibility of Results OTO - NOTNLM OT - Bioelectrical impedance analysis OT - Body composition OT - Caffeinated coffee OT - Decaffeinated coffee OT - Water COIS- Author declarations The authors declare no competing interests. EDAT- 2026/05/09 00:34 MHDA- 2026/05/28 00:29 CRDT- 2026/05/08 18:10 PHST- 2025/08/14 00:00 [received] PHST- 2026/04/02 00:00 [revised] PHST- 2026/04/06 00:00 [accepted] PHST- 2026/05/28 00:29 [medline] PHST- 2026/05/09 00:34 [pubmed] PHST- 2026/05/08 18:10 [entrez] AID - S0271-5317(26)00041-2 [pii] AID - 10.1016/j.nutres.2026.04.002 [doi] PST - ppublish SO - Nutr Res. 2026 Jun;150:62-71. doi: 10.1016/j.nutres.2026.04.002. Epub 2026 Apr 13. PMID- 42102625 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260714 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 89 DP - 2026 Jul-Aug TI - Nurse-led Buteyko versus diaphragmatic breathing retraining in hospitalized children with asthma: A three-group quasi-experimental study. PG - 330-340 LID - S0882-5963(26)00203-4 [pii] LID - 10.1016/j.pedn.2026.04.031 [doi] AB - BACKGROUND: Pediatric asthma may involve dysfunctional breathing patterns and autonomic dysregulation not directly addressed by pharmacotherapy. Comparative evidence on breathing retraining in hospitalized children remains limited. PURPOSE: To compare nurse-led Buteyko Breathing Technique (BBT) and Diaphragmatic Breathing Technique (DBT) versus routine care on heart rate (HR), respiratory rate (RR), systolic blood pressure (SBP), peripheral oxygen saturation (SpO(2)), Control Pause (CP) time, and Modified Becker's Score (MBS) in hospitalized children with bronchial asthma. DESIGN AND METHODS: A three-group quasi-experimental pretest-posttest study enrolled 90 hospitalized children aged 6-12 years in BBT, DBT, or routine care groups (30/group) at the inpatient pediatric department of a university hospital in Upper Egypt, preceded by a small pilot study with nine children (three per group) not included in the main analysis, which confirmed feasibility and informed sample-size refinement. Two nurse-delivered sessions (30-45 min each) were initiated 24-48 h after stabilization with prescribed pharmacotherapy. RESULTS: Both intervention groups were associated with significant reductions in HR and RR versus controls on adjusted analyses: HR (F = 6.72, p = .002, partial eta(2) = 0.136) and RR (F = 9.18, p < .001, partial eta(2) = 0.178). BBT was associated with the largest CP improvement; normalization (>/= 40 s) occurred in 60.0% of BBT versus 0% in DBT and controls (F = 12.05, p < .001, partial eta(2) = 0.221). SpO(2) normalized in 56.7% of BBT, 23.3% of DBT, and 0% of controls. Adjusted SBP differences were not significant (p = .250). CONCLUSIONS: Nurse-led breathing retraining was associated with short-term physiological improvement during pediatric asthma hospitalization, with BBT showing a greater association with improvement in CP and oxygenation. Given the non-randomized design, baseline severity imbalance, brief dose, and absence of follow-up, findings are preliminary and require confirmation in rigorously designed randomized controlled trials. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Ramadan, Osama Mohamed Elsayed AU - Ramadan OME AD - Pediatric Nursing Department, Faculty of Nursing, Cairo University, Cairo 11562, Egypt. Electronic address: osama_ramadan_85@cu.edu.eg. FAU - Mohamed, Aziza Ibrahim Abd El Kader AU - Mohamed AIAEK AD - Department of Nursing, Al Ghad College for Applied Medical Sciences, Jeddah 23344, Saudi Arabia; Department of Medical- Surgical Nursing, Faculty of Nursing, University, Cairo 11562, Egypt. Electronic address: Egypt.azizaibrahim@cu.edu.eg. FAU - Osman, Atiat AU - Osman A AD - Department of Pediatric Nursing, Faculty of Nursing, Aswan University, Sahary 81528, Egypt. Electronic address: dratiat.osman@nurs.svu.edu.eg. FAU - Mohamed, Fatma Abdellah AU - Mohamed FA AD - Department of Pediatric Nursing, Faculty of Nursing, South Valley University, Qena 83523, Egypt. Electronic address: fatmaabdellah@nurs.svu.edu.eg. FAU - Hafiz, Alaa AU - Hafiz A AD - Department of Maternity and Child Health, Faculty of Nursing, King Abdulaziz University, Jeddah 24123, Saudi Arabia. Electronic address: ahhafidh@kau.edu.sa. FAU - Abunar, Areej AU - Abunar A AD - Department of Maternity and Child Health, Faculty of Nursing, King Abdulaziz University, Jeddah 24123, Saudi Arabia. Electronic address: aabunaar@kau.edu.sa. FAU - Katooa, Nouran Essam AU - Katooa NE AD - Department of Maternity and Child Health, Faculty of Nursing, King Abdulaziz University, Jeddah 24123, Saudi Arabia. Electronic address: nkuttouaha@kau.edu.sa. FAU - Elsharkawya, Nadia Bassuoni AU - Elsharkawya NB AD - Department of Maternal and Child Health Nursing, College of Nursing, Jouf University, Sakaka 72388, Saudi Arabia. Electronic address: nelsharkawy@ju.edu.sa. FAU - Mahdy, Noura Mohammed AU - Mahdy NM AD - Department of Pediatric Nursing, Faculty of Nursing, New Valley University, El-Kharga 72511, Egypt. Electronic address: NoraM.Mahdy@Nrs.nvu.edu.eg. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260507 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM MH - Humans MH - Child MH - *Asthma/nursing/therapy/physiopathology/diagnosis MH - Male MH - Female MH - *Breathing Exercises/methods MH - Egypt MH - Child, Hospitalized MH - Treatment Outcome MH - Pilot Projects MH - Heart Rate MH - Diaphragm OTO - NOTNLM OT - Asthma OT - Breathing exercises OT - Child OT - Hospitalization OT - Pediatric nursing COIS- Declaration of competing interest The authors declare no known competing financial interests or personal relationships that could have appeared to influence the work reported in this manuscript. EDAT- 2026/05/09 00:34 MHDA- 2026/07/14 12:34 CRDT- 2026/05/08 18:08 PHST- 2026/03/09 00:00 [received] PHST- 2026/04/23 00:00 [revised] PHST- 2026/04/24 00:00 [accepted] PHST- 2026/07/14 12:34 [medline] PHST- 2026/05/09 00:34 [pubmed] PHST- 2026/05/08 18:08 [entrez] AID - S0882-5963(26)00203-4 [pii] AID - 10.1016/j.pedn.2026.04.031 [doi] PST - ppublish SO - J Pediatr Nurs. 2026 Jul-Aug;89:330-340. doi: 10.1016/j.pedn.2026.04.031. Epub 2026 May 7. PMID- 42102276 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260901 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 May 8 TI - Feasibility of Integrating Wearable Devices and Ecological Momentary Assessment for Real-Time Environmental Exposure Estimation: Proof-of-Concept Study. PG - e86615 LID - 10.2196/86615 [doi] LID - e86615 AB - BACKGROUND: Environmental exposures such as heat and air pollution are critical determinants of health, yet traditional assessment methods rely on stationary monitors or residential address proxies that fail to capture the exposures that individuals experience throughout the day. OBJECTIVE: This pilot study aimed to assess the feasibility of integrating ecological momentary assessment (EMA), wearable devices, and continuous GPS tracking to capture real-time environmental exposures and to explore associations with concurrent health outcomes. METHODS: In total, 7 young adults (aged approximately 16 to 24 years; 5/7, 71% female) wore Fitbit Charge 6 watches from July 2025 to August 2025 (mean 28.1, SD 1.1 days), recording sleep quality and duration, resting heart rate, breathing rate, heart rate variability, and physical activity. GPS location measured at up to 5-minute intervals (mean 19.7, SD 25.8 measurements per day) was linked to ambient temperature, humidity, and air pollution data (particulate matter <2.5 um or <10 um in diameter, nitrogen dioxide, sulfur dioxide, ozone, and carbon monoxide) derived from monitoring stations, satellites, and climate models using data-integration algorithms accessed via an application programming interface. EMA surveys administered 3 times per day captured participants' emotional states and location (inside or outside). Feasibility targets were >/=3 GPS measurements per day, >/=1 survey completed per day, and complete sleep data on >/=50% of days. We examined exploratory bivariate correlations between environmental exposures, physiological measures, and self-reported mood, adjusting for multiple comparisons using false discovery rate correction. RESULTS: Of the 7 participants, 5 (71%) met predefined feasibility targets. Mean compliance included 565 (SD 457) GPS coordinates per participant, 1.4 (SD 0.2) EMA surveys per day, and complete Fitbit sleep data on 64% (SD 27%) of days. Surveys identified barriers to compliance, including perceived complexity of the system and forgetting to put the Fitbit watch back on after removing it. Exploratory correlations (6/7, 86% of participants with complete Fitbit data) revealed associations between nitrogen dioxide and heat exposure and reduced heart rate variability (a marker of parasympathetic tone), and between air pollutants (sulfur dioxide) and increased negative emotions. Heat exposure showed a paradoxical pattern of lower self-reported sadness but reduced heart rate variability with higher levels of heat exposure. Given the small sample size, these correlations should be considered preliminary and hypothesis generating rather than definitive findings. CONCLUSIONS: This study demonstrates that the multimodal integration of wearable devices, GPS tracking, and EMA is feasible for capturing real-time environmental exposures and concurrent health outcomes in young adults. This approach addresses critical exposure misclassification issues in environmental health research that relies on residential addresses as proxies. Preliminary patterns suggest complex relationships between environmental exposures and both physiological and emotional outcomes, warranting further investigation in larger, more diverse samples. This approach could inform future personalized environmental health interventions. CI - (c) Sameera Ramjan, Rung-Yu Tseng, Katherine Davey, Ahmed Duke Shereen, Yoko Nomura. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Ramjan, Sameera AU - Ramjan S AUID- ORCID: 0000-0003-4311-5353 AD - Department of Psychology, Queens College, CUNY, 65-30 Kissena Blvd, Flushing, NY, 11367, United States, 1 718-997-3164. AD - Department of Psychology, The Graduate Center, CUNY, New York, NY, United States. FAU - Blum, Melissa AU - Blum M AUID- ORCID: 0000-0001-5372-9004 AD - Department of Psychology, Queens College, CUNY, 65-30 Kissena Blvd, Flushing, NY, 11367, United States, 1 718-997-3164. AD - Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States. FAU - Tseng, Rung-Yu AU - Tseng RY AUID- ORCID: 0009-0007-9779-8280 AD - Department of Psychology, Queens College, CUNY, 65-30 Kissena Blvd, Flushing, NY, 11367, United States, 1 718-997-3164. AD - Department of Psychology, The Graduate Center, CUNY, New York, NY, United States. AD - CUNY Advanced Science Research Center, New York, NY, United States. FAU - Davey, Katherine AU - Davey K AUID- ORCID: 0009-0001-5315-2505 AD - CUNY Advanced Science Research Center, New York, NY, United States. FAU - Shereen, Ahmed Duke AU - Shereen AD AUID- ORCID: 0000-0002-2293-5611 AD - Department of Psychology, The Graduate Center, CUNY, New York, NY, United States. AD - CUNY Advanced Science Research Center, New York, NY, United States. FAU - Nomura, Yoko AU - Nomura Y AUID- ORCID: 0000-0002-2143-3257 AD - Department of Psychology, Queens College, CUNY, 65-30 Kissena Blvd, Flushing, NY, 11367, United States, 1 718-997-3164. AD - Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States. AD - CUNY Advanced Science Research Center, New York, NY, United States. AD - Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, United States. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260508 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - *Wearable Electronic Devices/standards/statistics & numerical data MH - Female MH - *Ecological Momentary Assessment MH - Feasibility Studies MH - *Environmental Exposure/analysis/statistics & numerical data MH - Pilot Projects MH - Male MH - Adolescent MH - Young Adult MH - Proof of Concept Study MH - Digital Health PMC - PMC13155499 OTO - NOTNLM OT - air pollution OT - autonomic nervous system OT - digital health OT - eHealth OT - ecological momentary assessment OT - electronic health OT - environmental exposures OT - exposomics OT - geographic information systems OT - heat OT - mHealth OT - mental health OT - mobile health OT - mood OT - wearable devices COIS- Conflicts of Interest: None declared. EDAT- 2026/05/08 18:33 MHDA- 2026/05/08 18:34 PMCR- 2026/05/08 CRDT- 2026/05/08 14:42 PHST- 2025/11/10 00:00 [received] PHST- 2026/02/20 00:00 [revised] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/05/08 18:34 [medline] PHST- 2026/05/08 18:33 [pubmed] PHST- 2026/05/08 14:42 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - v10i1e86615 [pii] AID - 86615 [pii] AID - 10.2196/86615 [doi] PST - epublish SO - JMIR Form Res. 2026 May 8;10:e86615. doi: 10.2196/86615. PMID- 42102099 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 5 DP - 2026 TI - Research on the development and differentiation of the physical literacy scale for Chinese college students. PG - e0348776 LID - 10.1371/journal.pone.0348776 [doi] LID - e0348776 AB - OBJECTIVES: To understand the current status and characteristics of physical literacy among Chinese college students, develop a measurement scale suitable for this population, and provide an appropriate assessment tool for related research. METHODS: The Delphi method and a questionnaire survey were initially employed to screen and evaluate the reliability and validity of 53 preliminary items. Subsequently, the finalized measurement tool, which had been assessed for reliability, was administered to 3,077 Chinese college students via a questionnaire survey to identify population variation characteristics. RESULTS: Following a systematic screening process, the reliability coefficients for the four dimensions ranged from 0.731 to 0.821, and a reliable measurement tool for assessing physical literacy among Chinese college students was established. The final scale comprises four dimensions-physical activity capacity, physical activity behavior, physical activity cognition, and emotional experience-with a total of 32 items. The survey revealed significant differences in physical literacy among Chinese college students across the following dimensions: gender (t = 24.914, P < 0.001), household registration (t = 11.464, P < 0.001), grade (F = 30.811, P < 0.001), university category (F = 17.305, P < 0.001), and university district (F = 4.957, P < 0.01). Furthermore, significant differences were observed to varying degrees across all four dimensions-physical activity capacity, physical activity behavior, physical activity cognition, and emotional experience. CONCLUSION: The developed Physical Literacy Scale for Chinese College Students is suitable for research targeting this population. The survey revealed significant differences in physical literacy levels among Chinese college students based on gender, grade, household registration, university category, and university district. CI - Copyright: (c) 2026 Ni, Yu. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Ni, Rongjing AU - Ni R AUID- ORCID: 0000-0001-6133-9743 AD - Physical Education Institute, Liaoning Normal University, Dalian, China. FAU - Yu, Ying AU - Yu Y AUID- ORCID: 0000-0002-0810-3886 AD - Physical Education Institute, Liaoning Normal University, Dalian, China. LA - eng PT - Journal Article DEP - 20260508 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Students/psychology MH - Female MH - Male MH - Universities MH - Surveys and Questionnaires MH - China MH - Young Adult MH - Reproducibility of Results MH - Adolescent MH - *Exercise MH - Adult MH - *Health Literacy PMC - PMC13155614 COIS- The authors have declared that no competing interests exist. EDAT- 2026/05/08 18:33 MHDA- 2026/05/08 18:34 PMCR- 2026/05/08 CRDT- 2026/05/08 13:43 PHST- 2025/12/21 00:00 [received] PHST- 2026/04/19 00:00 [accepted] PHST- 2026/05/08 18:34 [medline] PHST- 2026/05/08 18:33 [pubmed] PHST- 2026/05/08 13:43 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - PONE-D-25-65782 [pii] AID - 10.1371/journal.pone.0348776 [doi] PST - epublish SO - PLoS One. 2026 May 8;21(5):e0348776. doi: 10.1371/journal.pone.0348776. eCollection 2026. PMID- 42102058 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260818 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 5 DP - 2026 TI - Prevalence, diagnostic methods, and clinical outcomes of wasting/cachexia among pediatric cancer patients in Africa: A protocol for a systematic review and meta-analysis. PG - e0349113 LID - 10.1371/journal.pone.0349113 [doi] LID - e0349113 AB - INTRODUCTION: Pediatric cancer is an emerging public health priority in Africa, where survival rates remain critically low compared to high-income regions. Malnutrition; specifically wasting and cachexia; is the most prevalent, yet modifiable comorbidity that compromises treatment tolerance and increases mortality. Recent primary studies from 2025 indicate a significant discrepancy between wasting diagnosed via clinical assessment versus anthropometrically defined wasting, suggesting a "hidden burden" of malnutrition in African oncology wards. However, no comprehensive synthesis of data exists regarding the prevalence of wasting across the continent using modern assessment standards, nor its specific impact on clinical outcomes in the current treatment era. METHODS AND ANALYSIS: We will conduct a systematic review and meta-analysis of observational studies (cross-sectional, cohort, and case-control) published from January 1, 2000, to the present. Data sources will include PubMed/MEDLINE, EMBASE, Web of Science and CINAHL. We will include studies involving children and adolescents (0-19 years) diagnosed with malignancies in African healthcare settings. Two independent reviewers will screen studies, extract data, and assess risk of bias using Covidence systematic review software. The risk of bias will be assessed using the Joanna Briggs Institute (JBI) critical appraisal tools. The primary outcome will be the pooled prevalence of wasting/cachexia. Secondary outcomes will include diagnostic accuracy of assessment methods (such as Mid-Upper Arm Circumference [MUAC] vs. Weight-for-Height vs. clinical assessment) and associations with adverse clinical events (neutropenia, sepsis, treatment abandonment, and mortality). A random-effects meta-analysis will be performed using R software. Heterogeneity will be assessed using the I2 statistic and explored via subgroup analyses (region, tumor type, and assessment tool). ETHICS AND DISSEMINATION: Ethical approval is not required as this study relies on secondary data. Findings will be disseminated through a peer-reviewed publication and conference presentations to inform nutritional guidelines for pediatric oncology in resource-limited settings. PROSPERO REGISTRATION NUMBER: Registration Number: CRD420251237859. CI - Copyright: (c) 2026 Pitua et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Pitua, Ivaan AU - Pitua I AUID- ORCID: 0000-0003-0768-1315 AD - School of Medicine, College of Health Sciences, Makerere University, Kampala, Uganda. FAU - Wannyana, Daisy AU - Wannyana D AUID- ORCID: 0009-0005-4401-5225 AD - Faculty of Health Sciences, Victoria University, Kampala, Uganda. FAU - Abila, Derrick Bary AU - Abila DB AUID- ORCID: 0000-0002-6763-5612 AD - Uganda Child Cancer Foundation, Kampala, Uganda. AD - Uganda Cancer Institute, Kampala, Uganda. FAU - Bongomin, Felix AU - Bongomin F AD - Department of Medical Microbiology, Faculty of Health Sciences, Gulu University, Gulu, Uganda. LA - eng PT - Journal Article DEP - 20260508 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Systematic Reviews as Topic MH - *Neoplasms/complications/epidemiology MH - Meta-Analysis as Topic MH - Child MH - Prevalence MH - *Cachexia/epidemiology/diagnosis/etiology MH - Africa/epidemiology MH - Adolescent MH - Child, Preschool MH - *Wasting Syndrome/epidemiology/diagnosis MH - Infant MH - Female MH - Research Design PMC - PMC13155595 COIS- The authors have declared that no competing interests exist. EDAT- 2026/05/08 18:33 MHDA- 2026/05/08 18:34 PMCR- 2026/05/08 CRDT- 2026/05/08 13:36 PHST- 2025/11/25 00:00 [received] PHST- 2026/04/26 00:00 [accepted] PHST- 2026/05/08 18:34 [medline] PHST- 2026/05/08 18:33 [pubmed] PHST- 2026/05/08 13:36 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - PONE-D-25-63072 [pii] AID - 10.1371/journal.pone.0349113 [doi] PST - epublish SO - PLoS One. 2026 May 8;21(5):e0349113. doi: 10.1371/journal.pone.0349113. eCollection 2026. PMID- 42101410 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260922 IS - 1878-2620 (Electronic) IS - 1499-4046 (Print) IS - 1499-4046 (Linking) VI - 58 IP - 8 DP - 2026 Aug TI - Bringing WISE Home: Feasibility and Effectiveness of a Preschool Nutrition Curriculum in Rural Home Visits. PG - 810-817 LID - S1499-4046(26)00072-2 [pii] LID - 10.1016/j.jneb.2026.03.008 [doi] AB - OBJECTIVE: To pilot Together, We Inspire Smart Eating(8) (WISE) curriculum in home visiting METHODS: We conducted a nonrandomized pilot trial with baseline and 6-month follow-up in Parents as Teachers programs in 2 rural counties. Eleven home visitors and 46 families with children aged 3-5 years participated. Intervention visitors delivered 6 monthly WISE lessons; controls received standard services. Outcomes included implementation measures, home visitor confidence, and parent and child fruit and vegetable intake via Veggie Meter. Linear regression tested intervention effects, controlling for baseline. RESULTS: Home visitors reported positive acceptability (3.56), feasibility (3.25), and appropriateness (3.22). Fidelity was moderate to high, with hands-on exposure observed in all lessons. The intervention was associated with child Veggie Meter scores (beta = 0.43, P = 0.007), yielding an 18.2% increase vs no change in controls; no effect was observed for parents (beta = 0.21, P = 0.20). CONCLUSIONS AND IMPLICATIONS: Together, We Inspire Smart Eating was feasible and acceptable in home visiting with promising effects. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Massey-Swindle, Taren AU - Massey-Swindle T AD - Arkansas Children's Nutrition Center, Little Rock, AR; Arkansas Children's Research Institute, Arkansas Children's Hospital, Little Rock, AR; Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR; Department of Family and Preventive Medicine, University of Arkansas for Medical Sciences, Little Rock, AR. Electronic address: tswindle@uams.edu. FAU - McKelvey, Lorraine AU - McKelvey L AD - Department of Family and Preventive Medicine, University of Arkansas for Medical Sciences, Little Rock, AR. FAU - Waller, Emily AU - Waller E AD - College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR. FAU - Waymire, Madison AU - Waymire M AD - College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR. FAU - Hamilton, Alecia AU - Hamilton A AD - Department of Family and Preventive Medicine, University of Arkansas for Medical Sciences, Little Rock, AR. FAU - Zhang, Dong AU - Zhang D AD - Department of Family and Preventive Medicine, University of Arkansas for Medical Sciences, Little Rock, AR. LA - eng GR - P20 GM109096/GM/NIGMS NIH HHS/United States GR - R01 DK138153/DK/NIDDK NIH HHS/United States GR - UL1 TR003107/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20260507 PL - United States TA - J Nutr Educ Behav JT - Journal of nutrition education and behavior JID - 101132622 SB - IM MH - Humans MH - Child, Preschool MH - *House Calls MH - Rural Population MH - Male MH - Feasibility Studies MH - Female MH - Pilot Projects MH - *Curriculum MH - *Health Education/methods MH - *Child Nutrition Sciences/education MH - *Health Promotion/methods MH - Fruit MH - Vegetables MH - Parents/education PMC - PMC13182775 MID - NIHMS2174507 OTO - NOTNLM OT - child OT - fruit and vegetable intake OT - home visits OT - nutrition education OT - preschool COIS- Conflict of Interest Disclosure Dr Taren Massey-Swindle and University of Arkansas for Medical Sciences have a financial interest in the technology (WISE) discussed in this presentation. These financial interests have been reviewed and approved in accordance with the UAMS conflict of interest policies. The remaining authors have not stated any conflicts of interest. EDAT- 2026/05/08 12:38 MHDA- 2026/08/09 15:14 PMCR- 2026/05/19 CRDT- 2026/05/08 10:29 PHST- 2025/05/08 00:00 [received] PHST- 2026/02/27 00:00 [revised] PHST- 2026/03/15 00:00 [accepted] PHST- 2026/08/09 15:14 [medline] PHST- 2026/05/08 12:38 [pubmed] PHST- 2026/05/08 10:29 [entrez] PHST- 2026/05/19 00:00 [pmc-release] AID - S1499-4046(26)00072-2 [pii] AID - 10.1016/j.jneb.2026.03.008 [doi] PST - ppublish SO - J Nutr Educ Behav. 2026 Aug;58(8):810-817. doi: 10.1016/j.jneb.2026.03.008. Epub 2026 May 7. PMID- 42101376 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1542-4758 (Electronic) IS - 1492-7535 (Print) IS - 1492-7535 (Linking) VI - 30 IP - 3 DP - 2026 Jul TI - Bioelectrical Impedance in Pediatric Dialysis: Clinical Applications, Limitations, and Opportunities. PG - 486-498 LID - 10.1111/hdi.70073 [doi] AB - BACKGROUND: Optimizing fluid and nutritional management is a cornerstone of care for children with end-stage kidney disease on dialysis. Inaccurate assessment of hydration status contributes to hypertension, fluid overload, and increased cardiovascular risk, while masking important changes in muscle and fat compartments that affect growth and long-term outcomes. Bioelectrical impedance analysis (BIA) offers clinicians a noninvasive, rapid, and practical tool to support decision-making in this setting. AIMS: This review aims to provide clinicians with a practical framework for the use of BIA in pediatric dialysis, including its clinical applications, limitations, and opportunities for integration into routine care. MATERIALS AND METHODS: A narrative review of the literature was conducted, and findings were synthesized focusing on the principles of BIA, device technologies, and clinical studies evaluating its use in pediatric dialysis populations. Emphasis was placed on studies addressing fluid assessment, body composition, and clinical implementation. Adult literature was included where pediatric literature was lacking. RESULTS: Available evidence suggests BIA can provide useful estimates of total body water, fat mass, and lean tissue that may support ultrafiltration strategies, nutritional assessment, and longitudinal monitoring. Key limitations include variability related to growth, delayed maturation, obesity, malnutrition, and reliance on adult-derived prediction equations. Current evidence supports BIA as an adjunctive tool integrated with clinical assessment rather than a standalone measure. DISCUSSION: BIA may enhance individualized fluid and nutritional management when interpreted within the clinical context and standardized measurement protocols. Broader implementation requires awareness of pediatric-specific limitations, interdisciplinary interpretation, and cautious use of device-derived estimates. CONCLUSION: BIA is a practical adjunct for pediatric dialysis care with potential to improve fluid management and nutritional monitoring. Pediatric-specific validation studies, standardized protocols, and integration with clinical outcomes is needed to optimize its utility. CI - (c) 2026 The Author(s). Hemodialysis International published by Wiley Periodicals LLC on behalf of International Society for Hemodialysis. FAU - Juarez-Calderon, Marisa AU - Juarez-Calderon M AD - Department of Renal & Pheresis Services, Texas Children's Hospital, Houston, Texas, USA. FAU - Geer, Jessica AU - Geer J AD - Department of Renal & Pheresis Services, Texas Children's Hospital, Houston, Texas, USA. AD - Department of Pediatrics, Section of Pediatric Nephrology, Baylor College of Medicine, Houston, Texas, USA. FAU - Wong Vega, Molly AU - Wong Vega M AUID- ORCID: 0000-0003-4732-4996 AD - Department of Renal & Pheresis Services, Texas Children's Hospital, Houston, Texas, USA. AD - Department of Pediatrics, Section of Pediatric Nephrology, Baylor College of Medicine, Houston, Texas, USA. LA - eng PT - Journal Article PT - Review DEP - 20260508 PL - Canada TA - Hemodial Int JT - Hemodialysis international. International Symposium on Home Hemodialysis JID - 101093910 SB - IM MH - Humans MH - *Electric Impedance MH - *Renal Dialysis/methods MH - Child MH - Body Composition MH - *Kidney Failure, Chronic/therapy PMC - PMC13350307 OTO - NOTNLM OT - dry weight assessment OT - fluid overload OT - fluid status OT - hydration status OT - nutritional risk COIS- The authors declare no conflicts of interest. EDAT- 2026/05/08 12:38 MHDA- 2026/07/10 12:46 PMCR- 2026/07/10 CRDT- 2026/05/08 10:23 PHST- 2026/04/02 00:00 [revised] PHST- 2025/09/25 00:00 [received] PHST- 2026/04/26 00:00 [accepted] PHST- 2026/07/10 12:46 [medline] PHST- 2026/05/08 12:38 [pubmed] PHST- 2026/05/08 10:23 [entrez] PHST- 2026/07/10 00:00 [pmc-release] AID - HDI70073 [pii] AID - 10.1111/hdi.70073 [doi] PST - ppublish SO - Hemodial Int. 2026 Jul;30(3):486-498. doi: 10.1111/hdi.70073. Epub 2026 May 8. PMID- 42101192 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1473-0766 (Electronic) IS - 0951-3590 (Linking) VI - 42 IP - 1 DP - 2026 Dec 31 TI - Inflammatory markers mediate the association of the Zhejiang University index with gestational diabetes mellitus: data from NHANES 2007-2020. PG - 2668870 LID - 10.1080/09513590.2026.2668870 [doi] AB - BACKGROUND: Gestational diabetes mellitus (GDM) threatens maternal and infant health, yet early prediction is challenging. The Zhejiang University (ZJU) index, reflecting insulin resistance and hepatic lipid metabolism, predicts metabolic diseases, but its role in GDM across multiethnic populations is unclear. METHODS: This study analyzed NHANES 2007-2020 data from US women aged 20-45. Weighted logistic regression, restricted cubic spline (RCS), subgroup, and ROC analyses assessed ZJU index and GDM. Mediation analysis evaluated inflammatory ratios. Sensitivity analysis excluded women with chronic diseases or medication use. RESULTS: Among 2240 women, 10% had GDM. Higher ZJU index was linearly associated with increased GDM risk; highest quartile had over twice the odds (OR = 2.25, 95% CI: 1.10-3.41). ZJU index outperformed BMI, FPG, ALT, AST (AUC = 0.718). PHR and LHR partially mediated the association. Sensitivity analysis confirmed robustness. CONCLUSION: ZJU index is a strong, independent predictor of GDM, outperforming traditional markers. HDL‑related inflammatory markers partially mediate this association, suggesting immunometabolic pathways. Further studies are needed for validation in broader populations. FAU - Ye, Mengmeng AU - Ye M AD - Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People's Republic of China. FAU - Wu, Haochan AU - Wu H AD - Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People's Republic of China. FAU - Shan, Fangfang AU - Shan F AD - Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People's Republic of China. FAU - Zhou, Hui AU - Zhou H AD - Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People's Republic of China. AD - Human Genetic and Reproduction Center, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People's Republic of China. FAU - Yu, Jinjin AU - Yu J AD - Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People's Republic of China. FAU - Wu, Yibo AU - Wu Y AD - Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People's Republic of China. AD - Human Genetic and Reproduction Center, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People's Republic of China. FAU - Hao, Tingting AU - Hao T AD - Department of Laboratory Medicine, Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, People's Republic of China. LA - eng PT - Journal Article DEP - 20260508 PL - England TA - Gynecol Endocrinol JT - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JID - 8807913 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Diabetes, Gestational/blood/epidemiology/diagnosis MH - Pregnancy MH - Adult MH - Biomarkers/blood MH - Nutrition Surveys MH - *Insulin Resistance/physiology MH - *Inflammation/blood MH - Young Adult MH - United States/epidemiology OTO - NOTNLM OT - Zhejiang University (ZJU) index OT - gestational diabetes mellitus (GDM) OT - inflammation OT - lymphocyte-to-HDL ratio (LHR) OT - platelet-to-HDL ratio (PHR) EDAT- 2026/05/08 12:37 MHDA- 2026/05/08 12:38 CRDT- 2026/05/08 09:23 PHST- 2026/05/08 12:38 [medline] PHST- 2026/05/08 12:37 [pubmed] PHST- 2026/05/08 09:23 [entrez] AID - 10.1080/09513590.2026.2668870 [doi] PST - ppublish SO - Gynecol Endocrinol. 2026 Dec 31;42(1):2668870. doi: 10.1080/09513590.2026.2668870. Epub 2026 May 8. PMID- 42101071 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260906 IS - 1601-6343 (Electronic) IS - 1601-6335 (Print) IS - 1601-6335 (Linking) VI - 29 IP - 5 DP - 2026 Oct TI - Three Data-Driven Lip Soft-Tissue Phenotypes and Their Dento-Skeletal Associations in Orthodontic Patients: An Exploratory Unsupervised Learning Study. PG - 888-898 LID - 10.1111/ocr.70138 [doi] AB - BACKGROUND: Conventional facial diagnosis emphasizes skeletal and dental measures while lip features are assessed piecemeal. We aimed to identify data-driven lip soft-tissue phenotypes using unsupervised machine learning and examine their associations with skeletal and dental characteristics. METHODS: In a retrospective cross-sectional study, 10 lip measurements were extracted from standardized lateral cephalometric radiographs. Variables were z-score standardized and analysed using k-means clustering. Of 26 NbClust validation indices, 14 (53.8%) supported a three-cluster solution. Cluster stability was assessed by bootstrap resampling (B = 100) and 10-fold cross-validation. Post hoc feature importance was evaluated using PCA, Random Forest, SVM and XGBoost. A decision tree was trained and evaluated by 10-fold cross-validation repeated five times. Associations with craniofacial parameters were examined via within-class ANOVA, Cramer's V and hierarchical regression. Concordant pairings were defined as Cluster 1-Class I, Cluster 2-Class II and Cluster 3-Class III; all others were classified as discordant. RESULTS: Three phenotypes emerged-Thin-Straight (n = 638), Protrusive-Convex (n = 644) and Thick-Concave (n = 389)-showing broad correspondence with skeletal Classes I, II and III, respectively (Cramer's V = 0.386; overall concordance 52.8%). Lip protrusion and thickness were the primary discriminators (4/4 method consensus for UL_EP_mm, Cm_Sn_Ls, SSD; 3/4 for ULT). Within each skeletal class, all lip variables differed significantly across phenotypes (all p < 0.001; eta(2) = 0.10-0.54 for lip variables), and lip phenotype independently predicted incisor inclination beyond skeletal covariates (DeltaR(2)adj = 0.058-0.078, p < 0.001). An interpretable decision tree achieved 88.0% cross-validated accuracy (macro-F1 = 0.876) for phenotype assignment. CONCLUSIONS: Unsupervised learning identified three reproducible lip soft-tissue phenotypes that complement conventional dentoskeletal description by capturing within-class soft-tissue heterogeneity. The framework is exploratory and requires prospective external validation and outcome-based studies before clinical triage application. CI - (c) 2026 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Zhang, Xiaoqi AU - Zhang X AUID- ORCID: 0000-0003-0707-0928 AD - State Key Laboratory of Oral Diseases, National Clinical Research Center of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. FAU - Xing, Lu AU - Xing L AD - State Key Laboratory of Oral Diseases, National Clinical Research Center of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. FAU - Ai-Gumaei, Waseem AU - Ai-Gumaei W AUID- ORCID: 0000-0001-7873-9516 AD - State Key Laboratory of Oral Diseases, National Clinical Research Center of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. FAU - Zhang, Xiaoqian AU - Zhang X AUID- ORCID: 0000-0003-4056-0080 AD - Yunnan Key Laboratory of Stomatology Affiliated Hospital of Stomatology School of Stomatology Kunming Medical University, Kunming, China. FAU - Long, Hu AU - Long H AUID- ORCID: 0000-0002-6020-6559 AD - State Key Laboratory of Oral Diseases, National Clinical Research Center of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. FAU - Li, Minqi AU - Li M AUID- ORCID: 0000-0001-9980-1382 AD - Department of Bone Metabolism, School and Hospital of Stomatology, Shandong University, Jinan, China. FAU - Lai, Wenli AU - Lai W AUID- ORCID: 0000-0002-7652-739X AD - State Key Laboratory of Oral Diseases, National Clinical Research Center of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. LA - eng PT - Journal Article DEP - 20260508 PL - England TA - Orthod Craniofac Res JT - Orthodontics & craniofacial research JID - 101144387 SB - IM MH - Humans MH - *Lip/anatomy & histology/diagnostic imaging MH - Phenotype MH - Retrospective Studies MH - Cross-Sectional Studies MH - Cephalometry MH - *Unsupervised Machine Learning MH - Clustering Algorithms MH - Female MH - *Malocclusion MH - Random Forest MH - Cluster Analysis MH - Adolescent MH - Boosting Machine Learning Algorithms PMC - PMC13543179 OTO - NOTNLM OT - facial profile OT - lip OT - machine learning OT - orthodontics OT - orthognathic surgery OT - soft tissue OT - unsupervised clustering COIS- The authors declare no conflicts of interest. EDAT- 2026/05/08 12:38 MHDA- 2026/09/04 17:40 PMCR- 2026/09/04 CRDT- 2026/05/08 08:24 PHST- 2026/04/07 00:00 [revised] PHST- 2025/11/09 00:00 [received] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/09/04 17:40 [medline] PHST- 2026/05/08 12:38 [pubmed] PHST- 2026/05/08 08:24 [entrez] PHST- 2026/09/04 00:00 [pmc-release] AID - OCR70138 [pii] AID - 10.1111/ocr.70138 [doi] PST - ppublish SO - Orthod Craniofac Res. 2026 Oct;29(5):888-898. doi: 10.1111/ocr.70138. Epub 2026 May 8. PMID- 42100063 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260508 LR - 20260813 IS - 2529-198X (Electronic) IS - 2529-198X (Linking) VI - 37 IP - 1 DP - 2026 Mar TI - Translation and Validation of the Greek Version of the Revised Fibromyalgia Impact Questionnaire (FIQR). PG - 156-163 LID - 10.31138/mjr.190525.ria [doi] AB - OBJECTIVE: Increasing awareness of chronic pain conditions, such as fibromyalgia, requires validated tools to monitor the impact of the disease and response to treatment. This study aimed to translate and validate the Revised Fibromyalgia Impact Questionnaire (FIQR) in Greek patients with fibromyalgia. METHODS: The FIQR was translated into Greek (FIQR-GR) using the forward-backward-forward method. A total of 311 adults participated in this validation study by completing questionnaires and reporting their demographic characteristics (age, gender, weight, height, education, profession, and number of children). Internal consistency was evaluated using Cronbach's alpha, and confirmatory factor analysis (CFA) was conducted to assess the structural validity of the tool. Regression models were used to test the association between FIQR and demographic characteristics. RESULTS: The FIQR-GR demonstrated excellent internal consistency (Cronbach's alpha=0.94, function domain 0.92, Overall Impact domain 0.85, symptoms domain 0.85). CFA revealed goodness of fit (CFI=0.900, RMSEA=0.080, SRMR=0.056) and confirmed the original three-factor model. Most items had high standardised factor loadings (0.51 to 0.86), providing strong evidence for validity, although two items had lower values than expected (0.40 for energy levels, 0.48 for depression). There was a significant positive association between FIQR and body mass index (BMI) (p<0.001), suggesting that patients with a higher BMI experienced more severe fibromyalgia symptoms. CONCLUSION: The FIQR-GR is a valid and reliable tool for Greek patients with fibromyalgia and a valuable tool in clinical and research settings. CI - (c) 2026 The Author(s). FAU - Gkouvi, Arriana AU - Gkouvi A AD - Immunonutrition Unit, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, Larissa, Greece. FAU - Pardali, Eleni C AU - Pardali EC AD - Immunonutrition Unit, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, Larissa, Greece. FAU - Kontouli, Katerina Maria AU - Kontouli KM AD - Laboratory of Hygiene and Epidemiology, Faculty of Medicine, University of Thessaly, Larissa, Greece. AD - Department of Primary Education, School of Education, University of Ioannina, Ioannina, Greece. FAU - Patrikiou, Eleni AU - Patrikiou E AD - Immunonutrition Unit, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, Larissa, Greece. FAU - Bogdanos, Dimitrios P AU - Bogdanos DP AD - Immunonutrition Unit, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, Larissa, Greece. FAU - Goulis, Dimitrios G AU - Goulis DG AD - Unit of Reproductive Endocrinology, 1 Department of Obstetrics and Gynaecology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Grammatikopoulou, Maria G AU - Grammatikopoulou MG AD - Immunonutrition Unit, Department of Rheumatology and Clinical Immunology, Faculty of Medicine, School of Health Sciences, University of Thessaly, Biopolis, Larissa, Greece. LA - eng PT - Journal Article DEP - 20260301 PL - Greece TA - Mediterr J Rheumatol JT - Mediterranean journal of rheumatology JID - 101730166 PMC - PMC13145287 OTO - NOTNLM OT - FIQR OT - Revised Fibromyalgia Impact Questionnaire OT - fibromyalgia OT - pain OT - validation COIS- None. EDAT- 2026/05/08 06:33 MHDA- 2026/05/08 06:34 PMCR- 2026/03/01 CRDT- 2026/05/08 05:01 PHST- 2025/05/19 00:00 [received] PHST- 2025/07/14 00:00 [revised] PHST- 2025/07/28 00:00 [accepted] PHST- 2026/05/08 06:34 [medline] PHST- 2026/05/08 06:33 [pubmed] PHST- 2026/05/08 05:01 [entrez] PHST- 2026/03/01 00:00 [pmc-release] AID - MJR-37-1-156 [pii] AID - 10.31138/mjr.190525.ria [doi] PST - epublish SO - Mediterr J Rheumatol. 2026 Mar 1;37(1):156-163. doi: 10.31138/mjr.190525.ria. eCollection 2026 Mar. PMID- 42100015 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260508 LR - 20260813 IS - 2296-875X (Print) IS - 2296-875X (Electronic) IS - 2296-875X (Linking) VI - 13 DP - 2026 TI - Optimal exercise prescription parameters in Schroth training for adolescent idiopathic scoliosis: a systematic review and meta-analysis. PG - 1796813 LID - 10.3389/fsurg.2026.1796813 [doi] LID - 1796813 AB - BACKGROUND: Adolescent idiopathic scoliosis (AIS) affects 0.5%-5% of the adolescent population, representing the most common spinal deformity in this age group. This systematic review and meta-analysis aimed to determine optimal exercise prescription parameters for Schroth training in AIS by examining dose-response relationships between exercise frequency, duration, and clinical outcomes. METHODS: Systematic searches of PubMed, Scopus, Web of Science, and SPORTDiscus were conducted following PRISMA 2020 guidelines. Randomized controlled trials examining Schroth interventions in adolescents aged 10-18 years with idiopathic scoliosis were included. Network meta-analysis was performed using MetaInsight platform for Cobb angle outcomes, with traditional pairwise meta-analyses conducted for all outcomes using standardized mean differences with 95% confidence intervals. RESULTS: 15 randomized controlled trials encompassing 620 participants were included. The overall meta-analysis demonstrated Schroth exercises produced statistically significant Cobb angle improvements (SMD = -0.52, p < 0.0001; I(2) = 0%). Subgroup analysis revealed dose-response relationships favouring moderate exercise frequencies (3-4 sessions/week), which showed the largest pooled effect (SMD = -0.58, I(2) = 3%). Duration analysis demonstrated medium duration interventions (46-75 min) provided the most precise improvements (MD = -2.92 degrees ), while optimal frequency was the moderate (MD = -2.79 degrees , 95% CI: -4.05, -1.48). Combined subgroup analysis identified moderate frequency plus medium duration as the most robust combination (SMD = -0.65, I(2) = 10%). Health-related quality of life outcomes showed non-significant improvements with substantial heterogeneity (SMD = 0.52, p = 0.43; I(2) = 93%). Secondary outcomes showed statistically significant improvements in trunk rotation (SMD = -0.86, p = 0.002; I(2) = 22%) and cosmetic appearance perception (SMD = -0.73, p = 0.01; I(2) = 0%), while postural stability measures showed non-significant effects (SMD = 0.08; p = 0.81; I(2) = 68%). Publication bias assessment using Egger's test shows no statistically significant funnel plot asymmetry (p = 0.745). CONCLUSIONS: Exploratory subgroup and network meta-analyses suggest that moderate frequency Schroth exercises (3-4 sessions/week) combined with medium duration sessions (46-75 min) may represent optimal parameters for Cobb angle improvement in AIS. Non-linear dose-response patterns show diminishing returns at higher frequencies, challenging conventional exercise prescription assumptions. These findings require validation through prospective studies with pre-specified dose-stratification examining long-term effectiveness, cost-effectiveness, and patient adherence across diverse healthcare contexts before broad clinical implementation. CI - (c) 2026 Guan, Liu, Yu and Cheng. FAU - Guan, Daoquan AU - Guan D AD - Anhui Communications Vocational & Technical College, Hefei, China. FAU - Liu, Yahui AU - Liu Y AD - Kyungwoon University, Gumi-si, Republic of Korea. FAU - Yu, Tongwu AU - Yu T AD - Capital University of Physical Education and Sports, Beijing, China. FAU - Cheng, Wen AU - Cheng W AD - Shinhan University, Uijeongbu-si, Gyeonggi-do, Republic of Korea. LA - eng PT - Journal Article PT - Review DEP - 20260422 PL - Switzerland TA - Front Surg JT - Frontiers in surgery JID - 101645127 PMC - PMC13143934 OTO - NOTNLM OT - Cobb angle OT - Schroth exercises OT - adolescent idiopathic scoliosis OT - dose response OT - meta-analysi OT - quality of life OT - systematic review COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/08 06:33 MHDA- 2026/05/08 06:34 PMCR- 2026/04/22 CRDT- 2026/05/08 05:01 PHST- 2026/01/27 00:00 [received] PHST- 2026/02/23 00:00 [revised] PHST- 2026/02/27 00:00 [accepted] PHST- 2026/05/08 06:34 [medline] PHST- 2026/05/08 06:33 [pubmed] PHST- 2026/05/08 05:01 [entrez] PHST- 2026/04/22 00:00 [pmc-release] AID - 10.3389/fsurg.2026.1796813 [doi] PST - epublish SO - Front Surg. 2026 Apr 22;13:1796813. doi: 10.3389/fsurg.2026.1796813. eCollection 2026. PMID- 42099720 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260508 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Acute psychological responses to official match outcomes in male youth volleyball: an observational repeated-measures study within a single national-level team. PG - 1826372 LID - 10.3389/fpsyg.2026.1826372 [doi] LID - 1826372 AB - BACKGROUND: Official match outcomes may be associated with acute psychological responses in youth athletes, particularly in team sports characterized by high emotional and interpersonal demands. OBJECTIVE: To examine acute psychological responses in male youth volleyball athletes during official matches in a national-level competition, focusing on associations with match outcome (win vs. loss), playing status (starter vs. substitute), and assessment moment (pre- vs. post-match). METHODS: Fourteen male athletes (mean age 16.5 +/- 0.82 years) from a single Brazilian national-level team were followed across 20 official matches (14 wins and 6 losses). Psychological responses were assessed before and/or after matches using validated instruments: State Anxiety (STAI-IDATE), Brunel Mood Scale (BRUMS), Feeling Scale, Physical Activity Enjoyment Scale (PACES), and Total Quality Recovery (TQR). Generalized estimating equations (GEE) were used with an independent working correlation structure and robust (sandwich) standard errors. Fixed effects included match outcome, playing status, assessment moment, and their interactions. Candidate marginal models were compared via Independence Model Criterion under a parsimonious strategy suitable for small samples. RESULTS: Losses were associated with increased post-match state anxiety, tension, depression, anger, and confusion, whereas wins were generally associated with stability or more favorable responses in these dimensions. Affective valence also showed an outcomexmoment interaction, declining after losses but remaining relatively stable after wins. Vigor demonstrated a three-way interaction between playing status, outcome, and moment, with substitutes showing a more pronounced decline after losses. Fatigue showed main effects of playing status, match outcome, and moment. Enjoyment was higher in wins than losses and higher in starters than substitutes. Perceived recovery showed a playing statusxoutcome interaction, with starters reporting higher pre-match recovery before matches that resulted in wins. CONCLUSION: In this single-team observational sample, acute psychological responses appeared to vary according to match outcome, playing status, and assessment moment. These findings should be interpreted as exploratory associations and may support the practical value of psychological monitoring in youth competitive volleyball. CI - Copyright (c) 2026 Do Nascimento, Sa Filho, Aprigliano, Clemente, Vieira, Campos, Rocha, Arantes, Pedrosa, Noll, Kawczynski, Laporta and Costa. FAU - Do Nascimento, Marcos Henrique AU - Do Nascimento MH AD - Programa de Pos-Graduacao em Ciencias da Saude, Faculdade de Medicina, Universidade Federal de Goias, Goiania, Brazil. FAU - Sa Filho, Alberto Souza AU - Sa Filho AS AD - Human Movement and Rehabilitation, Universidade Evangelica de Goias, Anapolis, Brazil. AD - Graduate Program at the Federal University of Rio de Janeiro, UFRJ, Rio de Janeiro, Brazil. FAU - Aprigliano, Vicente AU - Aprigliano V AD - Escuela de Ingenieria de Construccion y Transporte, Pontificia Universidad Catolica de Valparaiso, Valparaiso, Chile. FAU - Clemente, Filipe Manuel AU - Clemente FM AD - Department of Biomechanics, Gdansk University of Physical Education and Sport, Gdansk, Poland. AD - Applied Research Institute (i2A), Polytechnic University of Coimbra, Coimbra, Portugal. AD - Sport Physical Activity and Health Research & Innovation Center, Coimbra, Portugal. FAU - Vieira, Carlos Alexandre AU - Vieira CA AD - Programa de Pos-Graduacao em Ciencias da Saude, Faculdade de Medicina, Universidade Federal de Goias, Goiania, Brazil. FAU - Campos, Mario Hebling AU - Campos MH AD - Programa de Pos-Graduacao em Ciencias da Saude, Faculdade de Medicina, Universidade Federal de Goias, Goiania, Brazil. FAU - Rocha, Augusto Cezar Rodrigues AU - Rocha ACR AD - Programa de Pos-Graduacao em Ciencias da Saude, Faculdade de Medicina, Universidade Federal de Goias, Goiania, Brazil. FAU - Arantes, Debora Darck Lopes Costa AU - Arantes DDLC AD - Programa de Pos-Graduacao em Ciencias da Saude, Faculdade de Medicina, Universidade Federal de Goias, Goiania, Brazil. FAU - Pedrosa, Gustavo Ferreira AU - Pedrosa GF AD - Centro de Educacao Fisica e Desportos, Universidade Federal de Santa Maria, Santa Maria, Brazil. FAU - Noll, Matias AU - Noll M AD - Instituto Federal de Educacao, Ciencia e Tecnologia Goiano, Ceres, Brazil. FAU - Kawczynski, Adam AU - Kawczynski A AD - Faculty of Medicine, Wroclaw University of Science and Technology, Wroclaw, Poland. FAU - Laporta, Lorenzo AU - Laporta L AD - Centro de Educacao Fisica e Desportos, Universidade Federal de Santa Maria, Santa Maria, Brazil. FAU - Costa, Gustavo De Conti Teixeira AU - Costa GCT AD - Programa de Pos-Graduacao em Ciencias da Saude, Faculdade de Medicina, Universidade Federal de Goias, Goiania, Brazil. LA - eng PT - Journal Article DEP - 20260422 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13143687 OTO - NOTNLM OT - Brunel Mood Scale OT - Physical Activity Enjoyment Scale OT - Total Quality Recovery OT - affective valence OT - ecological validity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/08 06:32 MHDA- 2026/05/08 06:33 PMCR- 2026/04/22 CRDT- 2026/05/08 04:58 PHST- 2026/03/09 00:00 [received] PHST- 2026/04/03 00:00 [revised] PHST- 2026/04/10 00:00 [accepted] PHST- 2026/05/08 06:33 [medline] PHST- 2026/05/08 06:32 [pubmed] PHST- 2026/05/08 04:58 [entrez] PHST- 2026/04/22 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1826372 [doi] PST - epublish SO - Front Psychol. 2026 Apr 22;17:1826372. doi: 10.3389/fpsyg.2026.1826372. eCollection 2026. PMID- 42099518 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260508 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Status Quo analysis of an exercise therapy care model in pediatric oncology during acute therapy: perspectives from patients, parents, siblings, and staff. PG - 1791439 LID - 10.3389/fped.2026.1791439 [doi] LID - 1791439 AB - BACKGROUND: In oncological pediatrics, exercise therapy is still not part of regular medical care in Germany and exercise therapy projects are currently financed by charity organizations. Nevertheless, the scientific evidence for the benefit of exercise therapy in pediatric oncology has led to the implementation of exercise therapy programs at most of the German hospitals. At the Pediatric Oncology Department of the University Hospital of Cologne the exercise therapy program was established in 2021. Between 2023 and 2025 a comprehensive survey was carried out to assess the perception of various groups such as patients, family and staff with offered program. METHODS: A monocentric survey was conducted to assess the perception of patients, parents, siblings, and staff members regarding the exercise project using non-validated questionnaires. The questionnaires addressed the exercise project during intensive medical therapy in both the outpatient and inpatient phases. The questionnaires contained both open and closed questions and were evaluated using the following categories: "Communication/Education", "Participation", "Satisfaction", "Need for Support", "Online Exercise Sessions", and "Barriers and Motives". RESULTS: The survey was completed by 33 patients, 63 parents, 14 siblings and 48 staff members. The evaluation of the survey showed that more than 50% of the patients and parents surveyed were satisfied with the existing program. Parents and staff have particularly noted the lack of exercise therapy programs for patients during their outpatient phases. DISCUSSION: Despite the generally positive evaluation, patients, parents, siblings and staff still see potential for further development of the exercise therapy program, especially for the outpatient phases. CONCLUSION: Although the physical activity program is highly regarded, its potential is limited by gaps in outpatient care and inadequate sibling integration. To improve exercise therapy further, a holistic, family-centered approach must expand beyond the inpatient setting. Overcoming skepticism toward telehealth is crucial to ensuring accessible, sustainable exercise therapy outside the hospital.Clinical Trial Registration: https://drks.de/search/de/trial/DRKS00034629/details, identifier (DRKS00034629). CI - (c) 2026 Bohlke, Simon, Hero, Reinke, Friedrich, Zoth and Baumann. FAU - Bohlke, Lena AU - Bohlke L AD - Department of Pediatric Hematology and Oncology, University Hospital of Cologne, Cologne, Germany. FAU - Simon, Thorsten AU - Simon T AD - Department of Pediatric Hematology and Oncology, University Hospital of Cologne, Cologne, Germany. FAU - Hero, Barbara AU - Hero B AD - Department of Pediatric Hematology and Oncology, University Hospital of Cologne, Cologne, Germany. FAU - Reinke, Dana AU - Reinke D AD - Department of Pediatric Hematology and Oncology, University Hospital of Cologne, Cologne, Germany. FAU - Friedrich, Amrei AU - Friedrich A AD - Department of Pediatric Hematology and Oncology, University Hospital of Cologne, Cologne, Germany. FAU - Zoth, Nora AU - Zoth N AD - Department I of Internal Medicine, Center for Integrated Oncology Cologne Bonn, University Hospital of Cologne, Cologne, Germany. FAU - Baumann, Freerk T AU - Baumann FT AD - Department I of Internal Medicine, Center for Integrated Oncology Cologne Bonn, University Hospital of Cologne, Cologne, Germany. LA - eng PT - Journal Article DEP - 20260422 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13144044 OTO - NOTNLM OT - acute medical treatment OT - childhood cancer OT - exercise therapy OT - pediatric oncology OT - physical activity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/08 06:32 MHDA- 2026/05/08 06:33 PMCR- 2026/04/22 CRDT- 2026/05/08 04:55 PHST- 2026/01/19 00:00 [received] PHST- 2026/04/03 00:00 [revised] PHST- 2026/04/07 00:00 [accepted] PHST- 2026/05/08 06:33 [medline] PHST- 2026/05/08 06:32 [pubmed] PHST- 2026/05/08 04:55 [entrez] PHST- 2026/04/22 00:00 [pmc-release] AID - 10.3389/fped.2026.1791439 [doi] PST - epublish SO - Front Pediatr. 2026 Apr 22;14:1791439. doi: 10.3389/fped.2026.1791439. eCollection 2026. PMID- 42099515 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260508 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Co-occurrence of suspected scoliosis and sagittal spinal deviations among early adolescents: a school-based cross-sectional study of prevalence and associated factors. PG - 1769144 LID - 10.3389/fped.2026.1769144 [doi] LID - 1769144 AB - AIMS: This study aimed to investigate the prevalence and patterns of spinal postural abnormalities, particularly the co-occurrence of suspected scoliosis and sagittal spinal deviation, and to identify associated biological, behavioral, and psychosocial factors among early adolescents aged 12 to14 years. METHODS: A school-based, cross-sectional study was conducted among 255 school children aged 12 to 14 years. The standardized postural assessments and validated questionnaires were used to obtain data on the spinal alignment, anthropometric measures, pain location, and behavioral and psychosocial characteristics. Frontal and sagittal deviations were assessed through standardized visual inspection procedures. Frontal deviations indicating suspected scoliosis were further examined using the Adam's forward bending test and the angle of trunk rotation (ATR) measured with a scoliometer. Behavioral variables included screen time and preferred posture during screen use, while psychosocial variables comprised knowledge, attitude, and practice (KAP) and self-postural awareness questionnaires. Associated factors were identified by performing comparative analyses and binary logistic regression. RESULTS: Combined suspected scoliosis and sagittal spinal deviations were found in 21.2 percent of participants, with flattened thoracic curvature being the most frequent sagittal abnormality. Logistic regression revealed greater body height (AOR = 1.06, 95% CI: 1.02-1.11), lower KAP scores (AOR = 0.80, 95% CI: 0.72-0.89), while screen time (AOR = 1.22, 95% CI: 1.01-1.49) showed a more limited association with combined spinal deviations. Participants with suspected scoliosis reported more frequent upper back pain and lower self-postural awareness than those without deviations. CONCLUSION: A noteworthy proportion of early adolescents exhibited combined spinal deformities associated with biological and psychosocial-behavioral factors. Greater body height and lower KAP scores showed clearer associations with these conditions, whereas screen time demonstrated a tendency toward an association. These findings highlight the importance of incorporating posture assessment and health education into school-based initiatives. Improving early identification and encouraging healthy lifestyle behaviors may contribute to better spinal health and help reduce the risk of long-term musculoskeletal problems during adolescence. CI - (c) 2026 Nilmart and Vongsirinavarat. FAU - Nilmart, Patcharin AU - Nilmart P AD - Faculty of Physical Therapy, Srinakharinwirot University, Ongkharak, Nakhon Nayok, Thailand. FAU - Vongsirinavarat, Mantana AU - Vongsirinavarat M AD - Faculty of Physical Therapy, Mahidol University, Putthamonthon, Nakhon Pathom, Thailand. LA - eng PT - Journal Article DEP - 20260422 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13144105 OTO - NOTNLM OT - adolescents OT - health behavior OT - musculoskeletal health OT - school health OT - scoliosis OT - spinal curvature COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/08 06:32 MHDA- 2026/05/08 06:33 PMCR- 2026/04/22 CRDT- 2026/05/08 04:55 PHST- 2025/12/16 00:00 [received] PHST- 2026/01/28 00:00 [revised] PHST- 2026/04/08 00:00 [accepted] PHST- 2026/05/08 06:33 [medline] PHST- 2026/05/08 06:32 [pubmed] PHST- 2026/05/08 04:55 [entrez] PHST- 2026/04/22 00:00 [pmc-release] AID - 10.3389/fped.2026.1769144 [doi] PST - epublish SO - Front Pediatr. 2026 Apr 22;14:1769144. doi: 10.3389/fped.2026.1769144. eCollection 2026. PMID- 42098660 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 May 7 TI - Does stunting modify the impact of salivary factors and early childhood caries on oral health-related quality of life? LID - 10.1186/s12889-026-27304-5 [doi] LID - 1987 AB - BACKGROUND: Stunting, a form of chronic malnutrition, is associated with impaired growth and potential changes in salivary function that may increase susceptibility to early childhood caries (ECC). These oral conditions may further influence a child's oral health-related quality of life (OHRQoL). However, the extent to which stunting modifies the impact of salivary factors and ECC on OHRQoL remains unclear. METHODS: This analytical cross-sectional study included 210 preschool children aged 24-59 months in Bandung, Indonesia, equally divided into stunted and non-stunted groups based on height-for-age z-scores (HAZ <-2 SD for stunted). Dental caries was assessed using the deft index, while salivary pH and buffering capacity were measured using the GC Saliva Check Buffer Test. OHRQoL was evaluated using a modified Early Childhood Oral Health Impact Scale (ECOHIS) with a dichotomous response format (never = 0, ever = 1) validated through pilot testing (Cronbach's alpha = 0.870). Statistical analyses included Mann-Whitney U, Chi-square, and t-tests, followed by logistic regression with interaction terms to examine effect modification by stunting. RESULTS: Non-stunted children had higher mean deft scores (6.50 +/- 4.43) compared to stunted children (5.12 +/- 4.38, p = 0.020). Acidic Saliva was more frequent among stunted children (11.4%) than non-stunted children (3.8%, p = 0.037). However, no significant differences were observed in ECOHIS total scores or in the impact of OHRQoL between groups (p > 0.05). Logistic regression revealed no significant interactions between stunting, ECC, salivary pH, or buffering capacity (all p > 0.05). CONCLUSION: Stunting did not affect the association between salivary factors, early childhood caries, and oral health-related quality of life in preschool children. Although children with stunted had slightly higher salivary acidity, these differences did not result in measurable differences in quality of life. Prevention should combine oral health education and nutritional interventions to comprehensively address the risk of stunting and dental caries. CI - (c) 2026. The Author(s). FAU - Setiawan, Arlette Suzy AU - Setiawan AS AUID- ORCID: 0000-0001-5005-8081 AD - Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia. arlette.puspa@unpad.ac.id. FAU - Caesarini, Meitty AU - Caesarini M AD - Pediatric Dentistry Residency Program, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia. FAU - Musnamirwan, Iwan Ahmad AU - Musnamirwan IA AUID- ORCID: 0000-0002-2077-0630 AD - Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia. FAU - Primarti, Risti Saptarini AU - Primarti RS AUID- ORCID: 0009-0007-4456-3162 AD - Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia. FAU - Indriyanti, Ratna AU - Indriyanti R AUID- ORCID: 0000-0003-1864-5301 AD - Department of Pediatric Dentistry, Faculty of Dentistry, Universitas Padjadjaran, Bandung, Indonesia. LA - eng PT - Journal Article DEP - 20260507 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Dental Caries/epidemiology MH - Cross-Sectional Studies MH - Male MH - Female MH - *Quality of Life MH - Child, Preschool MH - *Saliva/chemistry/physiology MH - Indonesia/epidemiology MH - *Oral Health/statistics & numerical data MH - *Growth Disorders/complications/epidemiology MH - Hydrogen-Ion Concentration PMC - PMC13321754 OTO - NOTNLM OT - Child OT - Dental Caries OT - Growth Disorders OT - Hydrogen-Ion Concentration OT - Preschool OT - Quality of Life OT - Saliva COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical standards of the Health Research Ethics Committee of Universitas Padjadjaran and with the 1964 Helsinki Declaration and its later amendments. Ethical approval was obtained under reference number 125/UN6.KEP/EC/2025. Written informed consent was obtained from all participants and/or their legal guardians prior to participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. Clinical trial number: not applicable. EDAT- 2026/05/08 00:32 MHDA- 2026/07/01 12:47 PMCR- 2026/05/07 CRDT- 2026/05/07 23:45 PHST- 2025/12/24 00:00 [received] PHST- 2026/04/02 00:00 [accepted] PHST- 2026/07/01 12:47 [medline] PHST- 2026/05/08 00:32 [pubmed] PHST- 2026/05/07 23:45 [entrez] PHST- 2026/05/07 00:00 [pmc-release] AID - 10.1186/s12889-026-27304-5 [pii] AID - 27304 [pii] AID - 10.1186/s12889-026-27304-5 [doi] PST - epublish SO - BMC Public Health. 2026 May 7;26(1):1987. doi: 10.1186/s12889-026-27304-5. PMID- 42098338 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260921 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 6 DP - 2026 May 8 TI - Characterisation and non-pharmacological treatment of Complex Regional Pain Syndrome in under-18-year-olds: a scoping review. LID - 10.1007/s00431-026-07027-w [doi] LID - 364 AB - The aim of this review was to explore the published literature describing the presentation, characteristics, and non-pharmacological treatments of Complex Regional Pain Syndrome (CRPS) in under 18-year-olds. This scoping review was conducted in line with the Preferred Reporting Guidelines for Scoping Reviews (PRISMA-ScR). Five online databases (AMED, CINAHL + , EMBASE, EBSCO, and MEDLINE) were systematically searched with identified key terms for relevant records and screened against the eligibility criteria. Extracted data from the included studies informed a narrative synthesis. The PAGER framework was used to succinctly present gaps in the field and recommend future directions for research. Online searches yielded 140 articles. Following screening, 30 articles were included for review. Findings suggest primary symptoms included extreme pain, allodynia, and nail changes. The Budapest criteria, radiography, bone scans and laboratory examinations were commonly used diagnostic methods. Various non-pharmacological interventions were used, such as physiotherapy (home exercise), hydrotherapy, desensitisation, and cognitive behavioural therapy. CONCLUSION: The most common symptom in children is severe pain that is disproportionate to the inciting event. Critical gaps in the evidence base such as the absence of age appropriate, validated diagnostic criteria, lack of research understanding the lived experience and impact of the condition or exploring treatment efficacy, were identified as knowledge gaps within the field. WHAT IS KNOWN: * Complex Regional Pain Syndrome is a difficult to diagnose and hard to treat pain condition. Among children, it is not well documented or understood, there are no agreed diagnostic criteria or treatment guidelines. WHAT IS NEW: * This scoping review summarises and presents the published research regarding presentation, diagnosis and non-pharmacological treatment of paediatric CRPS. * Issues relating to the use of treatments lacking demonstrable efficacy and the need for quick and reliable diagnoses are discussed. * Using the PAGER Framework, this review exposes critical gaps in both research (the lack of research around condition experience and treatment efficacy) and practice (the lack of validated diagnostic criteria and treatment pathways) outlining clear and urgent recommendations. CI - (c) 2026. The Author(s). FAU - Budhraja, Mahira AU - Budhraja M AUID- ORCID: 0000-0001-6211-1580 AD - School of Health and Social Wellbeing, Centre for Health and Clinical Research, University of the West of England, Glenside Campus, Blackberry Hill, Bristol, BS16 1DD, UK. mahira.budhraja@uwe.ac.uk. FAU - Purvis, Ryan AU - Purvis R AUID- ORCID: 0009-0009-0711-627X AD - School of Health and Social Wellbeing, Centre for Health and Clinical Research, University of the West of England, Glenside Campus, Blackberry Hill, Bristol, BS16 1DD, UK. FAU - Tang, Katrina AU - Tang K AD - School of Health and Social Wellbeing, Centre for Health and Clinical Research, University of the West of England, Glenside Campus, Blackberry Hill, Bristol, BS16 1DD, UK. FAU - Lewis, Jennifer AU - Lewis J AUID- ORCID: 0000-0002-6503-3749 AD - School of Health and Social Wellbeing, Centre for Health and Clinical Research, University of the West of England, Glenside Campus, Blackberry Hill, Bristol, BS16 1DD, UK. AD - Bath National Pain Centre, Royal United Hospitals NHS Trust, Bath, UK. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260508 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Complex Regional Pain Syndromes/therapy/diagnosis MH - Adolescent MH - Child MH - Physical Therapy Modalities MH - Cognitive Behavioral Therapy PMC - PMC13152901 OTO - NOTNLM OT - CRPS OT - Children and young people OT - Clinical presentation OT - Complex Regional Pain Syndrome OT - Diagnosis OT - Occupational therapy OT - Paediatric OT - Paediatric chronic pain OT - Pediatric OT - Physiotherapy OT - Rehabilitation OT - Treatment COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/05/08 00:32 MHDA- 2026/05/08 00:33 PMCR- 2026/05/08 CRDT- 2026/05/07 23:27 PHST- 2026/01/20 00:00 [received] PHST- 2026/04/29 00:00 [accepted] PHST- 2026/04/27 00:00 [revised] PHST- 2026/05/08 00:33 [medline] PHST- 2026/05/08 00:32 [pubmed] PHST- 2026/05/07 23:27 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - 10.1007/s00431-026-07027-w [pii] AID - 7027 [pii] AID - 10.1007/s00431-026-07027-w [doi] PST - epublish SO - Eur J Pediatr. 2026 May 8;185(6):364. doi: 10.1007/s00431-026-07027-w. PMID- 42098264 OWN - NLM STAT- MEDLINE DCOM- 20260912 LR - 20261029 IS - 1476-5578 (Electronic) IS - 1359-4184 (Print) IS - 1359-4184 (Linking) VI - 31 IP - 10 DP - 2026 Oct TI - Physiological Age and Homeostatic Dysregulation Following Child Maltreatment in Youth. PG - 5586-5594 LID - 10.1038/s41380-026-03642-z [doi] AB - Child maltreatment has been associated with biological hallmarks of aging, including telomere shortening and epigenetic instability; however, its influence on physiological age and homeostatic dysregulation in early life remains unclear. The current study examined pediatric versions of physiological age and homeostatic dysregulation in children aged 8-13 with and without exposure to maltreatment. Maltreatment exposure was determined based on investigational records within 12 months prior to enrollment. Physiological measures were trained and validated utilizing external datasets - the National Health and Nutrition Examination Survey III and IV, respectively. Physiological age was computed using the Klemera-Doubal Method to indicate physiological developmental status. Homeostatic dysregulation level was computed as the Mahalanobis distance from an external reference group. 216 females and 245 males with a mean age of 11.4 years (SD 1.5) were included (76.6% White, 13.2% Black, and 13.0% Hispanic, 76.6% with maltreatment). Exposure to maltreatment was not associated with changes in physiological age but was associated with greater homeostatic dysregulation. Further analyses by maltreatment type and sex revealed that physical abuse was associated with greater homeostatic dysregulation, while sexual abuse was associated with delayed physiological development, specifically in males. Exposure to multiple types of maltreatment was associated with greater homeostatic dysregulation among males, but not among females. This study revealed that recent exposure to certain types of maltreatment may impair physiological development or regulation in children, with sex-specific patterns suggesting greater effects in males. Findings further indicate that physiological development composites in youth are sensitive to the impact of child maltreatment and can be incorporated in future work to evaluate the long-term sequelae of adverse exposures in pediatric populations. As the impact of maltreatment was only nominally significant after correction for multiple testing, validation work in other samples is needed. CI - (c) 2026. The Author(s). FAU - Ye, Qiaofeng AU - Ye Q AD - Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA. FAU - Apsley, Abner T AU - Apsley AT AD - National Science Foundation Science and Technology Center for Quantitative Cell Biology, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA. FAU - Etzel, Laura AU - Etzel L AD - Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA. FAU - Hastings, Waylon J AU - Hastings WJ AUID- ORCID: 0000-0003-0875-2568 AD - Department of Nutrition, Texas A&M University, College Station, TX, 77843, USA. AD - Institute for Advancing Health Through Agriculture, Texas A&M AgriLife, College Station, TX, 77843, USA. FAU - Chiaro, Christopher R AU - Chiaro CR AD - Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA. FAU - Schreier, Hannah M C AU - Schreier HMC AD - Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA. FAU - Claus, Eric D AU - Claus ED AUID- ORCID: 0000-0002-1800-0813 AD - Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA. FAU - Cohen, Alan A AU - Cohen AA AUID- ORCID: 0000-0003-4113-3988 AD - Department of Environmental Health Sciences and Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, 10032, USA. FAU - Fisher, Zachary AU - Fisher Z AD - Department of Psychology and Neuroscience, The University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA. FAU - Heim, Christine M AU - Heim CM AUID- ORCID: 0000-0002-6580-6326 AD - Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, Institute of Medical Psychology, Berlin, 10117, Germany. AD - Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt-Universitat zu Berlin, NeuroCure Cluster of Excellence, Berlin, 10117, Germany. AD - German Center for Mental Health, Berlin Potsdam partner site, Berlin, 10117, Germany. FAU - Noll, Jennie G AU - Noll JG AD - Department of Psychology, University of Rochester, Rochester, NY, 14627, USA. AD - Mt. Hope Family Center, University of Rochester, Rochester, NY, 14627, USA. FAU - Shenk, Chad E AU - Shenk CE AD - Department of Psychology, University of Rochester, Rochester, NY, 14627, USA. AD - Mt. Hope Family Center, University of Rochester, Rochester, NY, 14627, USA. FAU - Shalev, Idan AU - Shalev I AUID- ORCID: 0000-0003-0773-4835 AD - Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA. ius14@psu.edu. LA - eng GR - P50 HD089922/HD/NICHD NIH HHS/United States GR - P50HD089922/U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)/ GR - R44 TR000045/TR/NCATS NIH HHS/United States GR - UL1 TR00045/U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS)/ GR - UL1 TR002014/TR/NCATS NIH HHS/United States GR - UL1 TR002014/U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS)/ PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260508 PL - England TA - Mol Psychiatry JT - Molecular psychiatry JID - 9607835 SB - IM MH - Humans MH - Female MH - Male MH - Child MH - *Homeostasis/physiology MH - *Child Abuse/psychology MH - Adolescent MH - *Aging/physiology MH - Nutrition Surveys PMC - PMC13160224 MID - NIHMS2162078 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/05/08 00:32 MHDA- 2026/09/12 05:36 PMCR- 2026/05/08 CRDT- 2026/05/07 23:25 PHST- 2025/08/04 00:00 [received] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/03/31 00:00 [revised] PHST- 2026/09/12 05:36 [medline] PHST- 2026/05/08 00:32 [pubmed] PHST- 2026/05/07 23:25 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - 10.1038/s41380-026-03642-z [pii] AID - 3642 [pii] AID - 10.1038/s41380-026-03642-z [doi] PST - ppublish SO - Mol Psychiatry. 2026 Oct;31(10):5586-5594. doi: 10.1038/s41380-026-03642-z. Epub 2026 May 8. PMID- 42097861 OWN - NLM STAT- Publisher LR - 20260510 IS - 1932-2968 (Electronic) IS - 1932-2968 (Linking) DP - 2026 May 7 TI - The Automatic Correction Boluses in an Advanced Hybrid Closed-Loop System: Algorithm Performance and Clinical Implications. PG - 19322968261446967 LID - 10.1177/19322968261446967 [doi] LID - 19322968261446967 AB - BACKGROUND: Automatic correction boluses (ABs) are a key feature of advanced hybrid closed-loop systems, yet their clinical relevance remains incompletely characterized. METHODS: We retrospectively analyzed insulin delivery and continuous glucose monitoring (CGM) data from 287 individuals with type 1 diabetes using the MiniMed 780G for >/=6 months with >/=80% auto-mode usage, recruited from four diabetes centers in Sicily. We quantified the contribution of ABs to total daily insulin dose (TDD) and total bolus insulin and evaluated associations with demographic factors, pump settings, and dietary habits using multivariate regression and receiver operating characteristic (ROC) analyses. RESULTS: ABs accounted for 18.3% of TDD and 33.1% of total bolus insulin. AB/TDD was higher in pediatric participants and inversely associated with diabetes duration and AID use. Active insulin time and carbohydrate intake independently predicted AB/TDD. Higher AB/TDD was associated with lower time in range, higher glucose variability, time above range, and GMI; in pediatric participants, it was also associated with reduced time below range. An AB/TDD 70% (AUC 0.785) and /=20 is oft used to identify a probable eating disorder, previous work has shown that some items may reflect T1D management struggles, rather than DEB, with other work indicating that different response profiles (e.g., overeating vs. diabulimia) correspond to varying DEB risks. To identify DEPS-R items of greatest utility in detecting DEB in T1D, we used a form of item response theory to evaluate item variation in difficulty and discrimination, as well as scale precision across the latent DEB continuum. Participants were 329 adults with T1D who completed the DEPS-R when joining a participant registry or enrolling in a study on eating and weight concerns in T1D. We found a number of DEPS-R items (e.g., "I skip meals or snacks") that demonstrated low difficulty and low-to-moderate discrimination. These items were often endorsed by even the lowest severity participants yet provided relatively limited information for differentiating the DEB construct. Other items with high difficulty and moderate discrimination (e.g., "I make myself vomit") provided relatively modest information even at the highest pathology levels, as they were unlikely to be endorsed even by the most severe cases. Most high-discrimination items provided the most diagnostic information at the highest pathology levels (e.g., "I try to eat to the point of spilling ketones in my urine"). Results suggest revising the DEPS-R scale, as several items provided limited contribution to DEB detection. (PsycInfo Database Record (c) 2026 APA, all rights reserved). FAU - Dmitrieva, Natalia O AU - Dmitrieva NO AUID- ORCID: 0000-0001-7813-9131 AD - Department of Psychological Sciences, Northern Arizona University. FAU - Zhao, Corina Y AU - Zhao CY AD - Department of Counseling and Clinical Psychology, Teachers College, Columbia University. FAU - Moskovich, Ashley A AU - Moskovich AA AD - Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine. FAU - Roberts, Max Z AU - Roberts MZ AUID- ORCID: 0000-0002-5906-3992 AD - Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine. FAU - Merwin, Rhonda M AU - Merwin RM AUID- ORCID: 0000-0002-3729-0297 AD - Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine. LA - eng GR - R01 DK089329/DK/NIDDK NIH HHS/United States GR - DK/NIDDK NIH HHS/United States GR - JDRF/Breakthrough T1D/United States PT - Journal Article DEP - 20260507 PL - United States TA - Psychol Assess JT - Psychological assessment JID - 8915253 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/psychology/complications MH - Female MH - Adult MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Male MH - Middle Aged MH - Psychometrics MH - Young Adult MH - Surveys and Questionnaires MH - Adolescent PMC - PMC13152005 MID - NIHMS2153512 COIS- Conflicts of Interest: No authors nor their immediate family have a significant conflict of interest, nor any potential bias against another product or service. EDAT- 2026/05/07 12:37 MHDA- 2026/09/21 17:47 PMCR- 2026/05/08 CRDT- 2026/05/07 11:04 PHST- 2026/09/21 17:47 [medline] PHST- 2026/05/07 12:37 [pubmed] PHST- 2026/05/07 11:04 [entrez] PHST- 2026/05/08 00:00 [pmc-release] AID - 2027-65075-001 [pii] AID - 10.1037/pas0001471 [doi] PST - ppublish SO - Psychol Assess. 2026 Oct;38(10):704-715. doi: 10.1037/pas0001471. Epub 2026 May 7. PMID- 42095875 OWN - NLM STAT- MEDLINE DCOM- 20260831 LR - 20260921 IS - 1939-1536 (Electronic) IS - 0033-3204 (Print) IS - 0033-3204 (Linking) VI - 63 IP - 3 DP - 2026 Sep TI - Cognitive behavioral telehealth treatment for adolescents with loss-of-control eating: A randomized controlled feasibility study. PG - 340-351 LID - 10.1037/pst0000621 [doi] AB - This study aimed to develop and test the feasibility and acceptability of a telehealth treatment for adolescent loss-of-control (LOC) eating, including the feasibility of attaining clinically meaningful outcomes. LOC-eating episodes occur when experiencing a sense of LOC while eating a subjectively or objectively large amount of food. Participants were 55 adolescents (aged 12-17) with recurrent LOC-eating episodes and elevated weight (based on age and sex-normed percentiles) who enrolled in a feasibility trial of cognitive behavioral therapy (CBT). Five participants enrolled in the treatment development "open series" and provided feedback. Fifty participants were randomized to the subsequent randomized controlled trial and received either CBT-LOC or nutrition education. Treatment fidelity was checked. CBT-LOC for adolescents with LOC eating demonstrated treatment feasibility and acceptability. Retention (M = 15.3 of 16 sessions), treatment credibility (M = 5.26 of 6), and treatment fidelity (92%-100% of broad topics covered) were high. Treatment satisfaction was higher in CBT-LOC than nutrition education (ps < .001). Time x Intervention effects revealed greater improvements for CBT-LOC than nutrition education for binge eating, LOC eating, secretive eating, and global eating-disorder psychopathology. Weight change was minimal for both interventions. Among adolescents with weekly or greater baseline LOC-eating episodes, overvaluation of weight/shape and depression also improved. Overall, this feasibility randomized controlled trial testing CBT-LOC for adolescents experiencing LOC eating and elevated weight demonstrated feasibility and acceptability. Initial evidence demonstrated that it was feasible to produce clinically significant improvements in LOC-eating episodes, eating behaviors, and eating-disorder psychopathology. Few participants attained decreased weight, which may limit motivation to seek treatment from parents and adolescents. (PsycInfo Database Record (c) 2026 APA, all rights reserved). FAU - Lydecker, Janet A AU - Lydecker JA AUID- ORCID: 0000-0001-6425-514X AD - Department of Psychiatry, Yale University School of Medicine. FAU - Kamody, Rebecca AU - Kamody R AD - Department of Psychiatry, Yale University School of Medicine. FAU - Ozbardakci, Elise AU - Ozbardakci E AD - Department of Psychiatry, Yale University School of Medicine. FAU - Silverman, Wendy K AU - Silverman WK AUID- ORCID: 0000-0003-4415-4098 AD - Child Study Center, Yale University School of Medicine. FAU - Tanofsky-Kraff, Marian AU - Tanofsky-Kraff M AD - Department of Medical and Clinical Psychiatry, Uniformed Services University of the Health Sciences. FAU - Gueorguieva, Ralitza AU - Gueorguieva R AD - Department of Psychiatry, Yale University School of Medicine. FAU - Grilo, Carlos M AU - Grilo CM AD - Department of Psychiatry, Yale University School of Medicine. LA - eng GR - K23 DK115893/DK/NIDDK NIH HHS/United States GR - UL1 TR001863/TR/NCATS NIH HHS/United States GR - NH/NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial DEP - 20260507 PL - United States TA - Psychotherapy (Chic) JT - Psychotherapy (Chicago, Ill.) JID - 2984829R SB - IM MH - Humans MH - Adolescent MH - *Cognitive Behavioral Therapy/methods MH - Feasibility Studies MH - Female MH - Mental Health Teletherapy MH - Male MH - Child MH - *Feeding and Eating Disorders/therapy MH - Telemedicine MH - *Feeding Behavior/psychology MH - *Adolescent Behavior PMC - PMC13155366 MID - NIHMS2158347 EDAT- 2026/05/07 12:37 MHDA- 2026/08/31 19:42 PMCR- 2026/05/09 CRDT- 2026/05/07 11:03 PHST- 2026/08/31 19:42 [medline] PHST- 2026/05/07 12:37 [pubmed] PHST- 2026/05/07 11:03 [entrez] PHST- 2026/05/09 00:00 [pmc-release] AID - 2027-65835-001 [pii] AID - 10.1037/pst0000621 [doi] PST - ppublish SO - Psychotherapy (Chic). 2026 Sep;63(3):340-351. doi: 10.1037/pst0000621. Epub 2026 May 7. PMID- 42095152 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260507 LR - 20260813 IS - 2297-055X (Print) IS - 2297-055X (Electronic) IS - 2297-055X (Linking) VI - 13 DP - 2026 TI - Cardiopulmonary parameters in patients with Tetralogy of Fallot: the reference values for treadmill and cycle ergometer. PG - 1673478 LID - 10.3389/fcvm.2026.1673478 [doi] LID - 1673478 AB - BACKGROUND: The aim of this study was to establish sex- and age-specific reference values for ramp cycle-ergometer and treadmill cardiopulmonary exercise testing (CPET) in patients with Tetralogy of Fallot (ToF). Despite successful surgical repair, residual pulmonary regurgitation remains common in repaired ToF (rToF), often leading to right or left ventricular dysfunction and reduced exercise capacity. CPET is a reliable tool for evaluating cardiopulmonary function. Although both treadmill and cycle ergometer protocols are used interchangeably, reference value ranges for each method in this population remain unclear. METHOD: CPET data were collected from asymptomatic rToF patients who had undergone cardiac magnetic resonance imaging (CMR) and performed CPET on a treadmill or cycle ergometer between 2020 and 2024. Physical activity was assessed using the International Physical Activity Questionnaire (IPAQ). RESULTS: Among 290 patients, median age at CPET was 21.6 years (15.9-29.3), and median BMI was 22.5 kg/m(2) (20.0-24.9). Nearly all participants (99%) were in NYHA class I. Physical activity was classified as sedentary in 29%, moderate in 61%, and high in 9%. Median VO(2) peak was 26.4 mL/min/kg (23.0-31.5), corresponding to 72.9% predicted (62.4-83.2). Median oxygen pulse at peak was 9.9 mL/beat (8.2-12.0), with 76.9% predicted (68.0-87.5). Median VE/VCO(2) slope at the respiratory compensation point was 29.0 (26.0-32.6), and median oxygen uptake efficiency slope (OUES) was 1,792.5 mL/min/log(L/min) (1,535.0-2,181.5). VO(2) peak and percent-predicted VO(2) were significantly higher with treadmill testing in both sexes (p < 0.05); oxygen pulse was higher only in females. VE/VCO(2) slope and OUES were unaffected by modality. When stratified by age (<18 vs. >/=18 years), treadmill-related differences in VO(2) peak and percent-predicted VO(2) remained significant in both sexes >/=18 years, and in females <18 years. Oxygen pulse was significantly higher with treadmill only in females >/=18 years. VE/VCO(2) slope and OUES remained unchanged across modalities and age groups. CONCLUSION: This study provides CPET values stratified by modality and sex in a large cohort of asymptomatic rToF patients, offering valuable reference data for clinical assessment. Future studies should validate pediatric normative CPET values through prospective, inclusive, statistically powered cohorts using standardized protocols and cross-center comparability. CI - (c) 2026 Leonardi, Gentili, Tranchita, Montanaro, Butera, Palmieri, Di Gia, Secinaro, Antonelli, Lioncino and Giordano. FAU - Leonardi, Benedetta AU - Leonardi B AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Gentili, Federica AU - Gentili F AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Tranchita, Eliana AU - Tranchita E AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Montanaro, Claudia AU - Montanaro C AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Butera, Gianfranco AU - Butera G AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Palmieri, Rosalinda AU - Palmieri R AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Di Gia, Giulia AU - Di Gia G AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Secinaro, Aurelio AU - Secinaro A AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Antonelli, Giovanni AU - Antonelli G AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Lioncino, Michele AU - Lioncino M AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Giordano, Ugo AU - Giordano U AD - Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. LA - eng PT - Journal Article DEP - 20260421 PL - Switzerland TA - Front Cardiovasc Med JT - Frontiers in cardiovascular medicine JID - 101653388 PMC - PMC13139358 OTO - NOTNLM OT - Tetralogy of Fallot OT - VE/VCO(2) slope OT - VO2 peak OT - cardiopulmonary test OT - cyclo-ergometer OT - treadmil COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The authors BL, CM, GB declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/05/07 06:35 MHDA- 2026/05/07 06:36 PMCR- 2026/04/21 CRDT- 2026/05/07 05:21 PHST- 2025/07/25 00:00 [received] PHST- 2026/02/08 00:00 [revised] PHST- 2026/02/23 00:00 [accepted] PHST- 2026/05/07 06:36 [medline] PHST- 2026/05/07 06:35 [pubmed] PHST- 2026/05/07 05:21 [entrez] PHST- 2026/04/21 00:00 [pmc-release] AID - 10.3389/fcvm.2026.1673478 [doi] PST - epublish SO - Front Cardiovasc Med. 2026 Apr 21;13:1673478. doi: 10.3389/fcvm.2026.1673478. eCollection 2026. PMID- 42094888 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Optimal dose of aerobic exercise for improving postpartum depression, anxiety, and quality of life: a meta-analysis of randomized controlled trials and dose-response analysis. PG - 1807903 LID - 10.3389/fpubh.2026.1807903 [doi] LID - 1807903 AB - BACKGROUND: Postpartum depression, anxiety, and reduced health related quality of life (HRQoL) are common in the first year after childbirth, a period characterized by marked hormonal fluctuations, sleep disruption, and psychosocial role transitions that increase vulnerability to emotional distress, and have substantial consequences for maternal and child well-being. Aerobic exercise is increasingly recommended as a low-risk behavioral strategy, as it has been shown to improve mood, reduce stress, and modulate neurobiological pathways associated with depression, yet its effectiveness and optimal prescription parameters for postpartum mental health remain unclear. This study evaluated the effects of aerobic exercise on depressive symptoms, anxiety, and HRQoL, and characterized corresponding dose response patterns. METHODS: PubMed, Embase, CENTRAL, Web of Science, and Google Scholar were searched from inception to 31 October 2025. Randomized controlled trials lasting at least four weeks and comparing structured aerobic exercise with inactive or minimal control conditions were included. Outcomes were depressive symptoms, anxiety, and HRQoL assessed using validated instruments. Random effects meta-analyses generated standardized mean differences (SMDs). Dose response relationships were examined using model-based methods. RESULTS: Seventeen trials involving 2,865 women met inclusion criteria. Aerobic exercise significantly reduced depressive symptoms (SMD - 0.37, 95% CI - 0.60 to -0.14), with larger improvements in women with baseline depression and in interventions delivered postpartum. Dose response analysis showed a U-shaped pattern, with maximal benefit at approximately 570 MET minutes per week. No significant effect was found for anxiety (SMD - 0.11, 95% CI - 0.31 to 0.09). Aerobic exercise improved HRQoL (SMD 0.45, 95% CI 0.29 to 0.60), and an inverted U-shaped dose response indicated optimal gains near 420 MET minutes per week. CONCLUSION: Aerobic exercise reduces postpartum depressive symptoms and improves HRQoL. Optimal effects were observed at approximately 570 MET minutes per week for depression and 420 MET minutes per week for HRQoL, suggesting that a weekly volume of 400 to 600 MET minutes may be a practical target in postpartum care. Evidence remains insufficient to confirm anxiolytic effects. CI - Copyright (c) 2026 Cai, Du, Huang and Yang. FAU - Cai, Luqiong AU - Cai L AD - Department of Rehabilitation, Ningbo Rehabilitation Hospital, Ningbo, China. FAU - Du, Yuqing AU - Du Y AD - Department of Rehabilitation, Ningbo Rehabilitation Hospital, Ningbo, China. FAU - Huang, Yihui AU - Huang Y AD - Ningbo Psychiatric Hospital, Ningbo, China. FAU - Yang, Renjun AU - Yang R AD - Department of Rehabilitation, Jintang First People's Hospital, Chengdu, China. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260421 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - *Depression, Postpartum/therapy/prevention & control MH - *Quality of Life/psychology MH - *Anxiety/therapy/prevention & control MH - *Exercise/psychology MH - Randomized Controlled Trials as Topic PMC - PMC13139009 OTO - NOTNLM OT - aerobic exercise OT - dose-response analysis OT - postpartum anxiety OT - postpartum depression OT - quality of life COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/07 06:35 MHDA- 2026/05/07 06:36 PMCR- 2026/04/21 CRDT- 2026/05/07 05:18 PHST- 2026/02/10 00:00 [received] PHST- 2026/03/21 00:00 [revised] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/05/07 06:36 [medline] PHST- 2026/05/07 06:35 [pubmed] PHST- 2026/05/07 05:18 [entrez] PHST- 2026/04/21 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1807903 [doi] PST - epublish SO - Front Public Health. 2026 Apr 21;14:1807903. doi: 10.3389/fpubh.2026.1807903. eCollection 2026. PMID- 42094680 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260507 LR - 20260813 IS - 2673-4842 (Electronic) IS - 2673-4842 (Linking) VI - 7 DP - 2026 TI - Salivary pH within multifactorial caries risk assessment in children: observational clinical evidence using the Cariogram platform. PG - 1822466 LID - 10.3389/froh.2026.1822466 [doi] LID - 1822466 AB - INTRODUCTION: Dental caries is a multifactorial disease influenced by biological, behavioral, and preventive factors. Salivary pH has been proposed as a non-invasive biomarker for caries risk assessment, however, its independent clinical relevance within structured digital risk models remains unclear. This study school-aged pediatric cohort using the Cariogram platform as a structured, multifactorial caries risk assessment tool, and to evaluate the role of digitally measured salivary pH in relation to caries risk stratification and clinical caries indicators within this framework. METHODS: A total of 66 children aged 6-12 years were included. Unstimulated salivary pH was measured using both a digital pH meter and colorimetric strips. Caries risk was assessed using the Cariogram platform. Agreement between pH measurement methods was evaluated using Bland-Altman analysis. Associations between salivary pH, dietary intake frequency, and caries risk were explored using Spearman's rank correlation. A multivariable linear regression model was constructed using the Cariogram-derived chance to avoid new caries (%) as the dependent variable, including mean digitally measured salivary pH, dietary intake frequency, oral hygiene status, fluoride toothpaste use, age, gender, and saliva collection timing as predictors. RESULTS: Digital salivary pH values ranged from 6.1 to 7.2, with a peak between 6.6 and 6.8. Strip-based measurements systematically underestimated pH, with a mean bias of approximately 0.24 pH units. Salivary pH showed weak or negligible associations with Cariogram risk categories. In the multivariable model, dietary intake frequency, oral hygiene status, fluoride toothpaste use, and saliva collection timing were significant predictors of caries risk, whereas salivary pH was not independently associated after adjustment for behavioral and preventive factors. CONCLUSIONS: Salivary pH is a biologically relevant but insufficient standalone marker of caries risk in children. Its clinical value emerges when measured reliably and interpreted within a multifactorial, caries risk-assessment framework supported by digital tools, particularly the Cariogram platform and digital pH measurement. CI - (c) 2026 Barbulescu, Cristache, Vacarel and Nimigean. FAU - Barbulescu, Eliza Denisa AU - Barbulescu ED AD - Doctoral School, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. FAU - Cristache, Corina Marilena AU - Cristache CM AD - Department of Dental Techniques, Faculty of Midwifery and Nursing, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. FAU - Vacarel, Elena Valentina AU - Vacarel EV AD - Doctoral School, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. FAU - Nimigean, Vanda Roxana AU - Nimigean VR AD - Department of Oral Rehabilitation, Faculty of Dentistry, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. LA - eng PT - Journal Article DEP - 20260421 PL - Switzerland TA - Front Oral Health JT - Frontiers in oral health JID - 9918227262706676 PMC - PMC13139144 OTO - NOTNLM OT - Cariogram OT - caries risk assessment OT - digital diagnostics OT - pediatric dentistry OT - preventive dentistry COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author CC declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/05/07 06:37 MHDA- 2026/05/07 06:38 PMCR- 2026/04/21 CRDT- 2026/05/07 05:15 PHST- 2026/03/03 00:00 [received] PHST- 2026/03/25 00:00 [revised] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/05/07 06:38 [medline] PHST- 2026/05/07 06:37 [pubmed] PHST- 2026/05/07 05:15 [entrez] PHST- 2026/04/21 00:00 [pmc-release] AID - 10.3389/froh.2026.1822466 [doi] PST - epublish SO - Front Oral Health. 2026 Apr 21;7:1822466. doi: 10.3389/froh.2026.1822466. eCollection 2026. PMID- 42094652 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260507 LR - 20260813 IS - 2753-4294 (Electronic) IS - 2753-4294 (Linking) VI - 4 IP - 2 DP - 2026 TI - Evaluating a community-based care package delivered by trained nurses to improve preconception and maternal-child health: protocol of a stepped-wedge cluster randomised trial. PG - e003266 LID - 10.1136/bmjph-2025-003266 [doi] LID - e003266 AB - INTRODUCTION: Preconception care (PCC) plays a pivotal role in improving maternal and child health outcomes by addressing health risks and promoting healthy behaviours before pregnancy. This study aimed to evaluate the impact of village-level PCC delivered by trained auxiliary nurse midwives on preconception health and maternal-child health outcomes among eligible women in central Maharashtra, India. It also sought to identify factors influencing the implementation and utilisation of the PCC package, assess the feasibility of the intervention using the Reach, Effectiveness, Adoption, Implementation, and Maintenance(RE-AIM) framework and analyse the unit cost of delivering community-based PCC interventions. METHODS AND ANALYSIS: This study follows an open cohort stepped-wedge cluster randomised design with repeated cross-sectional sampling over 3 years, allowing phased implementation of the PCC package and systematic evaluation. It is being carried out in rural villages of the Wardha Community Development block, working closely with the District Health System and local Village Councils. The study includes 96 villages (clusters) under four primary health centres that agreed to a social franchisee model and an estimated 3200 eligible women. Women aged 19-45 years who had not completed their families, gave consent and had lived in the area for at least 2 years were eligible to participate. The PCC package, delivered through village clinics by trained community nurses, focuses on improving nutrition, reproductive health, vaccination coverage and mental health. This will be compared with routine government services provided before the intervention. Information collected includes participants' background, lifestyle habits such as diet and physical activity, stress levels, physical measurements, haemoglobin levels and how well the intervention was followed. The data will be analysed using regression models, including subgroup analysis based on participation and outcomes. The PCC package is expected to help reduce undernutrition, anaemia and maternal depression. The implementation will be evaluated using the RE-AIM framework, and final results are expected by the end of 2026, demonstrating the effectiveness and practicality of providing PCC through community health systems in rural areas. ETHICS AND DISSEMINATION: Ethical approval was obtained from the Institutional Ethics Committee of Mahatma Gandhi Institute of Medical Sciences, India (IEC/406/2023, dated 30 December 2023) prior to trial initiation. Study findings will be disseminated through peer-reviewed publications and presentations at national and international conferences. In addition, results will be shared with participating communities, Village Health, Nutrition and Sanitation Committees, district and state health authorities through stakeholder meetings. TRIAL REGISTRATION NUMBER: CTRI/2024/03/064582. CI - Copyright (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. Published by BMJ Group. FAU - Kalai, Sophiya AU - Kalai S AD - Department of Community Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India. FAU - Kalantri, Ashwini AU - Kalantri A AD - Department of Community Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India. FAU - Misra, Swati AU - Misra S AUID- ORCID: 0000-0003-1020-1239 AD - Department of Community Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India. FAU - Mundra, Anuj AU - Mundra A AD - Department of Community Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India. FAU - Kolhe, Rutuja AU - Kolhe R AD - Department of Community Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India. FAU - Jakasania, Arjunkumar AU - Jakasania A AD - Department of Community Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India. FAU - Mahajan, Kamlesh AU - Mahajan K AD - Department of Community Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India. FAU - Sathe, Harshal AU - Sathe H AD - Department of Psychiatry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India. FAU - Patil, Bharat AU - Patil B AD - Department of Pathology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India. FAU - Raut, Abhishek V AU - Raut AV AD - Department of Community Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India. FAU - Maliye, Chetna AU - Maliye C AD - Department of Community Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India. FAU - Jain, Shuchi AU - Jain S AD - Department of Obstetrics & Gynecology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India. FAU - Kumar, Satish AU - Kumar S AD - Department of Biochemistry, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India. FAU - Paradkar, Rameshwar J AU - Paradkar RJ AD - Zilla Parishad, District Health Office, Wardha, Maharashtra, India. FAU - Gupta, Subodh S AU - Gupta SS AD - Department of Community Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India. FAU - Varma, Poonam AU - Varma P AD - Department of Obstetrics & Gynecology, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India. FAU - Garg, Bishan S AU - Garg BS AD - Department of Community Medicine, Mahatma Gandhi Institute of Medical Sciences, Sevagram, Maharashtra, India. LA - eng PT - Journal Article DEP - 20260420 PL - England TA - BMJ Public Health JT - BMJ public health JID - 9918697578906676 PMC - PMC13141123 OTO - NOTNLM OT - Community Health OT - Community-Based Participatory Research OT - Public Health COIS- None declared. EDAT- 2026/05/07 06:36 MHDA- 2026/05/07 06:37 PMCR- 2026/04/20 CRDT- 2026/05/07 05:15 PHST- 2025/05/23 00:00 [received] PHST- 2026/03/06 00:00 [accepted] PHST- 2026/05/07 06:37 [medline] PHST- 2026/05/07 06:36 [pubmed] PHST- 2026/05/07 05:15 [entrez] PHST- 2026/04/20 00:00 [pmc-release] AID - bmjph-2025-003266 [pii] AID - 10.1136/bmjph-2025-003266 [doi] PST - epublish SO - BMJ Public Health. 2026 Apr 20;4(2):e003266. doi: 10.1136/bmjph-2025-003266. eCollection 2026. PMID- 42093997 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - Diagnostic and metabolic insights into secondary lactose intolerance in infants via fecal lactose quantification and gut microbiome profiling. PG - 1711945 LID - 10.3389/fimmu.2026.1711945 [doi] LID - 1711945 AB - BACKGROUND: Secondary Lactose intolerance (SLI) is common among infants in China, primarily resulting from secondary lactase deficiency due to mucosal damage. Current diagnostic methods are limited by poor sensitivity and specificity. OBJECTIVE: To investigate gut microbial composition and metabolic dysfunction in infants with SLI and to explore the potential utility of residual fecal lactose as a non-invasive indicator related to SLI. RESULTS: SLI infants exhibited significantly higher residual fecal lactose and lactate levels accompanied by reduced fecal short-chain fatty acid (SCFA) availability, consistent with incomplete lactose digestion and altered microbial fermentation. Microbiota profiling revealed marked depletion of Bacteroidetes and certain Firmicutes (e.g. Ruminococcaceae, Erysipelotrichaceae, Peptostreptococcaceae, Megasphaera), along with reduced glycolysis pathways. In vitro fermentation assays demonstrated a consistent reduction in total acid, acetate, and propionate production across multiple media, while lactate and gas production were significantly elevated in SLI samples under lactose, FOS, GOS, and starch-enriched conditions. Butyrate synthesis was partially preserved under protein-rich or minimal carbon media, indicating selective resilience of butyrogenic pathways. Microbial beta-diversity analysis confirmed structural dysbiosis, with increased abundance of gas-associated taxa, including Clostridium. CONCLUSION: Residual fecal lactose, when interpreted alongside microbial and metabolic profiles, may serve as a non-invasive indicator associated with secondary lactose intolerance in infants. These findings delineate microbiota-metabolism features consistent with SLI pathophysiology and provide a conceptual framework for future validation studies and the development of nutritional or probiotic interventions. CI - Copyright (c) 2026 Kuang, Zhang, Bian, Wang, Li, Wu and Li. FAU - Kuang, Jian AU - Kuang J AD - State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou, China. AD - Key Laboratory of Postharvest Preservation and Processing of Vegetables (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Hangzhou, China. AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Zhejiang Academy of Agricultural Sciences, Hangzhou, China. FAU - Zhang, Mengmei AU - Zhang M AD - Department of Gastroenterology, Children's Hospital of Soochow University, Suzhou, China. FAU - Bian, Xiangyu AU - Bian X AD - State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou, China. AD - Key Laboratory of Postharvest Preservation and Processing of Vegetables (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Hangzhou, China. AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Zhejiang Academy of Agricultural Sciences, Hangzhou, China. FAU - Wang, Xin AU - Wang X AD - State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou, China. AD - Key Laboratory of Postharvest Preservation and Processing of Vegetables (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Hangzhou, China. AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Zhejiang Academy of Agricultural Sciences, Hangzhou, China. FAU - Li, Xiaoqiong AU - Li X AD - State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou, China. AD - Key Laboratory of Postharvest Preservation and Processing of Vegetables (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Hangzhou, China. AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Zhejiang Academy of Agricultural Sciences, Hangzhou, China. FAU - Wu, Qingbin AU - Wu Q AD - Department of Gastroenterology, Children's Hospital of Soochow University, Suzhou, China. FAU - Li, Jinjun AU - Li J AD - State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-Products, Institute of Food Science, Zhejiang Academy of Agricultural Sciences, Hangzhou, China. AD - Key Laboratory of Postharvest Preservation and Processing of Vegetables (Co-construction by Ministry and Province), Ministry of Agriculture and Rural Affairs, Hangzhou, China. AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, Zhejiang Academy of Agricultural Sciences, Hangzhou, China. LA - eng PT - Journal Article DEP - 20260421 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - J2B2A4N98G (Lactose) RN - 0 (Fatty Acids, Volatile) SB - IM MH - Humans MH - *Feces/chemistry MH - *Lactose Intolerance/diagnosis/metabolism/microbiology/etiology MH - *Lactose/metabolism/analysis MH - *Gastrointestinal Microbiome MH - Infant MH - Female MH - Male MH - Dysbiosis MH - Fatty Acids, Volatile/metabolism MH - Fermentation PMC - PMC13139010 OTO - NOTNLM OT - 16s rRNA OT - SCFAs OT - gut microbiota OT - in vitro fermentation OT - lactose glycolysis metabolism OT - secondary lactose intolerance COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/07 06:34 MHDA- 2026/05/07 06:35 PMCR- 2026/04/21 CRDT- 2026/05/07 05:09 PHST- 2025/09/24 00:00 [received] PHST- 2026/01/13 00:00 [revised] PHST- 2026/01/20 00:00 [accepted] PHST- 2026/05/07 06:35 [medline] PHST- 2026/05/07 06:34 [pubmed] PHST- 2026/05/07 05:09 [entrez] PHST- 2026/04/21 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1711945 [doi] PST - epublish SO - Front Immunol. 2026 Apr 21;17:1711945. doi: 10.3389/fimmu.2026.1711945. eCollection 2026. PMID- 42093526 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260925 IS - 1552-5732 (Electronic) IS - 0890-3344 (Linking) VI - 42 IP - 3 DP - 2026 Aug TI - In Situ Simulation in Prenatal Breastfeeding Education: A Pilot Study. PG - 703-716 LID - 10.1177/08903344261430473 [doi] AB - BACKGROUND: Breastfeeding education should be initiated during pregnancy. Simulation is an effective educational technique that has been little explored in the context of prenatal education. RESEARCH AIM: To evaluate the feasibility and effectiveness of an in situ simulation scenario about breastfeeding, as a prenatal educational intervention at home, on breastfeeding self-efficacy and related outcomes. METHODS: This was a nonrandomized pilot intervention study with pre-test/post-test, conducted from October 2022 to November 2023. Pregnant people who received a home visit that provided an in situ simulation scenario entitled "Breastfeeding the Newborn" during prenatal care (n = 20) were compared to those who received only routine guidance (n = 20). Breastfeeding self-efficacy scores, exclusive breastfeeding rates, and difficulties in breastfeeding 2 months after delivery were evaluated and compared. RESULTS: In the intragroup comparisons, a significant increase in breastfeeding self-efficacy scores was found among simulation participants (p < 0.01). Most participants were exclusively breastfeeding (n = 12, 60%) and reported no difficulties (n = 11, 55%) 2 months after delivery. However, no significant differences were found between groups. The findings also demonstrated the feasibility of implementing the in situ simulation scenario "Breastfeeding the Newborn" during the prenatal period. CONCLUSIONS: This pilot study supports the potential of in situ simulation as an educational approach for prenatal breastfeeding promotion. Further research with larger samples and extended follow-up is recommended to explore its impact on breastfeeding outcomes. FAU - Natarelli, Taison Regis Penariol AU - Natarelli TRP AUID- ORCID: 0000-0002-4578-8626 AD - University of Sao Paulo, Ribeirao Preto, Brazil. FAU - Fonseca, Luciana Mara Monti AU - Fonseca LMM AD - University of Sao Paulo, Ribeirao Preto, Brazil. FAU - Campbell, Suzanne Hetzel AU - Campbell SH AD - University of British Columbia, Vancouver, Canada. FAU - Bressan, Silvia AU - Bressan S AD - University of Padova, Padova, Italy. FAU - Camelo, Jose Simon Jr AU - Camelo JS Jr AD - University of Sao Paulo, Ribeirao Preto, Brazil. FAU - Leite, Adriana Moraes AU - Leite AM AD - University of Sao Paulo, Ribeirao Preto, Brazil. FAU - Ferreira, Fernanda Medrado de Souza AU - Ferreira FMS AD - University of Sao Paulo, Ribeirao Preto, Brazil. LA - eng PT - Journal Article DEP - 20260507 PL - United States TA - J Hum Lact JT - Journal of human lactation : official journal of International Lactation Consultant Association JID - 8709498 SB - IM MH - Humans MH - Pilot Projects MH - Female MH - *Breast Feeding/psychology/methods MH - Pregnancy MH - Adult MH - *Prenatal Education/methods MH - Infant, Newborn MH - Self Efficacy MH - *Prenatal Care/methods MH - Feasibility Studies MH - *Simulation Training/methods OTO - NOTNLM OT - Breastfeeding Self-Efficacy Scale (BSES & BSES-SF) OT - breastfeeding OT - educational intervention OT - health education OT - lactation education OT - pilot study OT - prenatal education OT - primary health care OT - self-efficacy OT - simulation training COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/05/07 06:36 MHDA- 2026/09/25 17:32 CRDT- 2026/05/07 04:13 PHST- 2026/09/25 17:32 [medline] PHST- 2026/05/07 06:36 [pubmed] PHST- 2026/05/07 04:13 [entrez] AID - 10.1177/08903344261430473 [doi] PST - ppublish SO - J Hum Lact. 2026 Aug;42(3):703-716. doi: 10.1177/08903344261430473. Epub 2026 May 7. PMID- 42093187 OWN - NLM STAT- MEDLINE DCOM- 20260720 LR - 20260720 IS - 1872-6623 (Electronic) IS - 0304-3959 (Linking) VI - 167 IP - 8 DP - 2026 Aug 1 TI - The role of physical activity in children and adolescents with chronic pain: the moderating effects of psychological symptoms and sleep difficulties. PG - 1824-1838 LID - 10.1097/j.pain.0000000000003997 [doi] AB - Chronic pain in children and adolescents affects physical, psychological, social, and academic function. Although physical activity may play a role, its direct effects and its interactions with sleep difficulties and psychological symptoms remain unclear. This cross-sectional study examined whether physical activity is associated with chronic pain, and whether these associations vary by sleep difficulties and psychological symptoms. We analyzed data from 212,105 individuals (49% girls, age: 11-15 years) from the 2018 Health Behavior in School-aged Children study. Chronic pain, psychological symptoms, sleep difficulties, moderate-to-vigorous physical activity (MVPA), and vigorous physical activity (VPA) were assessed using validated self-report measures. Three multivariate logistic regression models (for chronic back pain, stomachache, and headache) examined main and moderation effects, adjusting for age, gender identity, and socioeconomic status. In adjusted main-effects models, higher MVPA was associated with higher odds of chronic back pain (aOR 1.15, 95% CI 1.06-1.25) and stomachache (aOR 1.02, 95% CI 1.00-1.09) but not headache. Interaction models indicated that MVPA associations differed by sleep difficulties, and the VPA-pain association differed by psychological symptoms. In stratified analyses, several MVPA frequency categories (vs 0 d/wk) were associated with lower odds of back pain and stomachache in both low and high sleep-difficulty groups. Vigorous physical activity was associated with lower odds of back pain and stomachache among adolescents with moderate or high psychological symptoms but not those with low symptom frequency. Overall, physical activity was not uniformly protective; associations were pain-type specific and varied according to adolescents sleep and psychological profiles. CI - Copyright (c) 2026 International Association for the Study of Pain. FAU - Ceniza-Bordallo, Guillermo AU - Ceniza-Bordallo G AUID- ORCID: 0000-0003-3012-666 AD - Department of Psychiatry, Center for Health Outcomes and Interdisciplinary Research, Massachusetts General Hospital, Boston, MA, United States. AD - Department of Psychiatry, Harvard Medical School, Boston, MA, United States. FAU - Sanchez-Rodriguez, Elisabet AU - Sanchez-Rodriguez E AD - Unit for the Study and Treatment of Pain-ALGOS, Research Center for Behavior Assessment (CRAMC), Department of Psychology, Universitat Rovira i Virgili, Catalonia, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili, Universitat Rovira i Virgili, Catalonia, Spain. FAU - Roman-Juan, Josep AU - Roman-Juan J AD - Department of Psychology, University of Calgary, Calgary, AB, Canada. FAU - Jensen, Mark P AU - Jensen MP AD - Department of Rehabilitation Medicine, University of Washington, Seattle, WA, United States. FAU - Miro, Jordi AU - Miro J AUID- ORCID: 0000-0002-1998-6653 AD - Unit for the Study and Treatment of Pain-ALGOS, Research Center for Behavior Assessment (CRAMC), Department of Psychology, Universitat Rovira i Virgili, Catalonia, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili, Universitat Rovira i Virgili, Catalonia, Spain. LA - eng PT - Journal Article DEP - 20260507 PL - United States TA - Pain JT - Pain JID - 7508686 SB - IM MH - Humans MH - Female MH - Child MH - Adolescent MH - *Chronic Pain/psychology/epidemiology/physiopathology MH - Male MH - *Sleep Wake Disorders/psychology/epidemiology MH - Cross-Sectional Studies MH - *Exercise/psychology/physiology OTO - NOTNLM OT - Biopsychosocial model OT - Pediatric chronic pain OT - Physical activity OT - Psychological symptoms OT - Sleep difficulties EDAT- 2026/05/07 06:38 MHDA- 2026/07/20 12:40 CRDT- 2026/05/07 02:03 PHST- 2025/03/22 00:00 [received] PHST- 2026/03/15 00:00 [accepted] PHST- 2026/07/20 12:40 [medline] PHST- 2026/05/07 06:38 [pubmed] PHST- 2026/05/07 02:03 [entrez] AID - 00006396-202608000-00015 [pii] AID - 10.1097/j.pain.0000000000003997 [doi] PST - ppublish SO - Pain. 2026 Aug 1;167(8):1824-1838. doi: 10.1097/j.pain.0000000000003997. Epub 2026 May 7. PMID- 42092586 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260730 IS - 1531-5037 (Electronic) IS - 0022-3468 (Linking) VI - 61 IP - 8 DP - 2026 Aug TI - Should we continue to follow the swallow? Limited value of routine preoperative upper gastrointestinal (UGI) series in pediatric and adolescent metabolic and bariatric surgery patients. PG - 163177 LID - S0022-3468(26)00260-5 [pii] LID - 10.1016/j.jpedsurg.2026.163177 [doi] AB - BACKGROUND: Hiatal hernia is frequently encountered intraoperatively during metabolic and bariatric surgery (MBS) in adults with relatively poor diagnostic accuracy on preoperative imaging. However, data on pediatric MBS populations is limited. We aimed to determine the prevalence of hiatal hernias in a pediatric bariatric cohort and evaluate the utility of preoperative upper gastrointestinal (UGI) series. METHODS: We conducted a retrospective review of 94 patients who underwent preoperative UGI series and sleeve gastrectomy from November 2023 to July 2025. Primary outcomes were the prevalence of hiatal hernias on UGI, concordance between UGI and intraoperative findings, and associations with reflux symptoms. RESULTS: Hiatal hernia was identified in one patient (1.1%) on preoperative UGI series, which was consistent with intraoperative findings of a hiatal hernia in the same patient who underwent repair. Gastroesophageal reflux was identified on UGI in 19/90 patients (21%). Of 7 patients (7.4%) who had reflux symptoms preoperatively, only 3 had reflux on UGI. Three months postoperatively, 4/90 patients (4.4%) reported reflux symptoms, 2 of whom had preoperative symptoms and reflux on UGI. CONCLUSIONS: The prevalence of hiatal hernias in the pediatric MBS population is exceedingly low, and preoperative UGI findings failed to demonstrate meaningful findings. This suggests that UGI is not a useful predictive tool in this setting and routine preoperative evaluation for hiatal hernias may not be warranted. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Lim, Jiyun AU - Lim J AD - Children's Hospital Los Angeles and Keck School of Medicine of USC, Department of Surgery, Division of Pediatric Surgery, Los Angeles, CA, United States. Electronic address: jilim@chla.usc.edu. FAU - Kim, Aimee G AU - Kim AG AD - Children's Hospital Los Angeles and Keck School of Medicine of USC, Department of Surgery, Division of Pediatric Surgery, Los Angeles, CA, United States. FAU - Vidmar, Alaina P AU - Vidmar AP AD - Children's Hospital Los Angeles and Keck School of Medicine of USC, Department of Pediatrics, Center for Endocrinology, Diabetes and Metabolism, Los Angeles, CA, United States. FAU - Vu, My H AU - Vu MH AD - Children's Hospital Los Angeles and The Saban Research Institute Biostatistics Core, Los Angeles, CA, United States. FAU - Samakar, Kamran AU - Samakar K AD - Children's Hospital Los Angeles and Keck School of Medicine of USC, Department of Surgery, Division of Pediatric Surgery, Los Angeles, CA, United States; Division of Upper Gastrointestinal and General Surgery, Department of Surgery, Keck Medical Center of University of Southern California, Los Angeles, CA, United States. FAU - Martin, Matthew J AU - Martin MJ AD - Children's Hospital Los Angeles and Keck School of Medicine of USC, Department of Surgery, Division of Pediatric Surgery, Los Angeles, CA, United States; Division of Upper Gastrointestinal and General Surgery, Department of Surgery, Keck Medical Center of University of Southern California, Los Angeles, CA, United States. FAU - Abel, Stuart A AU - Abel SA AD - Children's Hospital Los Angeles and Keck School of Medicine of USC, Department of Surgery, Division of Pediatric Surgery, Los Angeles, CA, United States; Division of Upper Gastrointestinal and General Surgery, Department of Surgery, Keck Medical Center of University of Southern California, Los Angeles, CA, United States. FAU - Belteton, Gisell Figueroa AU - Belteton GF AD - Children's Hospital Los Angeles and Keck School of Medicine of USC, Department of Pediatrics, Center for Endocrinology, Diabetes and Metabolism, Los Angeles, CA, United States. FAU - Wong, Harry J AU - Wong HJ AD - Children's Hospital Los Angeles and Keck School of Medicine of USC, Department of Surgery, Division of Pediatric Surgery, Los Angeles, CA, United States; Division of Upper Gastrointestinal and General Surgery, Department of Surgery, Keck Medical Center of University of Southern California, Los Angeles, CA, United States. LA - eng PT - Journal Article DEP - 20260504 PL - United States TA - J Pediatr Surg JT - Journal of pediatric surgery JID - 0052631 SB - IM MH - Humans MH - *Hernia, Hiatal/epidemiology/diagnosis/diagnostic imaging MH - Retrospective Studies MH - Female MH - Child MH - *Bariatric Surgery MH - Adolescent MH - Male MH - *Preoperative Care/methods MH - Prevalence MH - *Gastroesophageal Reflux/diagnosis/epidemiology/etiology MH - Gastrectomy OTO - NOTNLM OT - Hiatal hernia OT - Metabolic and bariatric surgery OT - Obesity medications OT - Pediatric obesity COIS- Conflict of interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/07 06:36 MHDA- 2026/07/31 00:38 CRDT- 2026/05/07 00:09 PHST- 2025/12/30 00:00 [received] PHST- 2026/03/30 00:00 [revised] PHST- 2026/04/26 00:00 [accepted] PHST- 2026/07/31 00:38 [medline] PHST- 2026/05/07 06:36 [pubmed] PHST- 2026/05/07 00:09 [entrez] AID - S0022-3468(26)00260-5 [pii] AID - 10.1016/j.jpedsurg.2026.163177 [doi] PST - ppublish SO - J Pediatr Surg. 2026 Aug;61(8):163177. doi: 10.1016/j.jpedsurg.2026.163177. Epub 2026 May 4. PMID- 42092297 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1365-277X (Electronic) IS - 0952-3871 (Print) IS - 0952-3871 (Linking) VI - 39 IP - 3 DP - 2026 Jun TI - Can Artificial Intelligence Chatbots Plan Therapeutic Ketogenic Diets for Children With Epilepsy? PG - e70263 LID - 10.1111/jhn.70263 [doi] LID - e70263 AB - RATIONALE: Ketogenic Diet Therapy (KDT) is an effective but complex treatment for paediatric drug-resistant epilepsy. Access to trained dietitians limits the global use of KDT. The increasing use of artificial intelligence (AI) chatbots for health and dietary advice presents both opportunities and risks. This exploratory study evaluates the accuracy and feasibility of AI-generated KDT plans for paediatric epilepsy. METHODS: We conducted a comparative analysis of three major AI chatbots: ChatGPT, Microsoft Copilot, and Gemini. Three clinical vignettes, one for each KDT type, were created to represent common KDT diet plans: the Classic Ketogenic Diet (Classic KD), the Medium-Chain Triglyceride (MCT) diet, and the Modified Atkins Diet (MAD). Two KDT dietitians evaluated the AI-generated diet plans for accuracy of macronutrient calculations, appropriateness of food choices, and overall safety and feasibility. RESULTS: All three chatbots failed to produce accurate KD plans. In the Classic KD, none of the chatbots generated menus that matched their calculated macronutrient targets, resulting in widely varying and inaccurate ketogenic ratios. For the MCT diet, the generated menus provided significantly less MCT than prescribed and failed to meet the caloric and macronutrient goals. For the MAD, the chatbots exceeded the specified net carbohydrate limits and provided inappropriate food suggestions. CONCLUSION: AI chatbots, in their current state, are not reliable or safe for generating KDT plans for children with epilepsy. The inaccuracies in macronutrient calculations and inappropriate food suggestions pose significant risks. This study underscores the critical need for human oversight by qualified professionals in the clinical application of AI for specialised dietary therapies. CI - (c) 2026 The Author(s). Journal of Human Nutrition and Dietetics published by John Wiley & Sons Ltd on behalf of British Dietetic Association. FAU - Ajmera, Faye AU - Ajmera F AUID- ORCID: 0009-0001-2046-246X AD - University of Toronto. FAU - Lowe, Helen AU - Lowe H AD - Department of Paediatrics, Division of Neurology, The Hospital for Sick Children, Toronto, Canada. FAU - Dickson, Jolynn AU - Dickson J AD - Department of Paediatrics, Division of Neurology, The Hospital for Sick Children, Toronto, Canada. FAU - Owusu, Karen AU - Owusu K AD - Department of Paediatrics, Division of Neurology, The Hospital for Sick Children, Toronto, Canada. FAU - Zak, Maria AU - Zak M AD - Department of Paediatrics, Division of Neurology, The Hospital for Sick Children, Toronto, Canada. FAU - Sharma, Suvasini AU - Sharma S AUID- ORCID: 0000-0002-3135-3306 AD - Division of Neurology, Department of Paediatrics, Temerty Faculty of Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Canada. LA - eng PT - Comparative Study PT - Journal Article PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Humans MH - *Diet, Ketogenic/methods MH - Child MH - *Artificial Intelligence MH - Female MH - *Drug Resistant Epilepsy/diet therapy MH - *Epilepsy/diet therapy MH - Diet, High-Protein Low-Carbohydrate MH - Male MH - Feasibility Studies MH - Diet, Carbohydrate-Restricted PMC - PMC13149770 OTO - NOTNLM OT - ChatGPT OT - Google Gemini OT - Microsoft Copilot OT - classic ketogenic diet OT - medium chain triglyceride ketogenic diet OT - modified Atkins diet COIS- The authors declare no conflicts of interest. EDAT- 2026/05/07 00:32 MHDA- 2026/05/07 06:35 PMCR- 2026/05/07 CRDT- 2026/05/06 23:53 PHST- 2026/04/13 00:00 [revised] PHST- 2026/03/05 00:00 [received] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/05/07 06:35 [medline] PHST- 2026/05/07 00:32 [pubmed] PHST- 2026/05/06 23:53 [entrez] PHST- 2026/05/07 00:00 [pmc-release] AID - JHN70263 [pii] AID - 10.1111/jhn.70263 [doi] PST - ppublish SO - J Hum Nutr Diet. 2026 Jun;39(3):e70263. doi: 10.1111/jhn.70263. PMID- 42090986 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1878-7487 (Electronic) IS - 1752-928X (Linking) VI - 120 DP - 2026 May TI - AgeMiner: A novel metadata-integrated chronological age predictor based on bone mineral density data. PG - 103149 LID - S1752-928X(26)00081-8 [pii] LID - 10.1016/j.jflm.2026.103149 [doi] AB - The estimation of chronological age based on bone mineral density (BMD) metrics for specific anatomical sites is a critical task in forensic anthropology. Although dual-energy X-ray absorptiometry (DXA) scans of the distal 1/3 of radius and ulna are widely used in large-scale osteoporosis screenings, forensic studies leveraging such data remain scarce. This study utilized a retrospective dataset (spanning ages 12-96) of 5,134 DXA scans from the distal 1/3 radius and ulna. We analyzed these DXA scans with metadata, including sex, body mass index (BMI), and osteoporosis diagnoses, to train machine learning models. Linear regression (LR), support vector regression (SVR), random forest regression (RFR), XGBoost (XGB), and LightGBM (LGBM) models were optimized via Bayesian cross-validation. Results indicate that the simplest model constructed solely based on BMD data + Diagnoses showed good performance with a mean absolute error (MAE) of 2.40 years. The best-performing model was the RFR model built using the combination of Female + Diagnoses, with an MAE of 2.18 years. When only considering BMI, the best model was the RFR model for the Normal weight + Diagnoses combination, with an MAE of 2.54 years. These models have been integrated into the AgeMiner tool (https://github.com/Rarapie/AgeMiner), allowing forensic users to select the optimal model according to metadata of the tested person, thereby enabling fast and end-to-end chronological age estimation. In summary, AgeMiner and its integrated ML models provide an efficient, accurate, and customizable tool for forensic age estimation in adults and the elderly. CI - Copyright (c) 2026 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved. FAU - Lei, Fanzhang AU - Lei F AD - Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, 510515, China. FAU - Wang, Yuanyuan AU - Wang Y AD - Department of Health Management, Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. FAU - Yuan, Xi AU - Yuan X AD - Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, 510515, China. FAU - Wu, Chengkai AU - Wu C AD - School of Public Health, Southern Medical University, Guangzhou, 510515, China; School of Health Management, Southern Medical University, Guangzhou, 510515, China; Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. FAU - Fu, Jing AU - Fu J AD - Nanfang Hospital, Southern Medical University, Guangzhou, 510515, China. FAU - Mao, Chen AU - Mao C AD - Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, 510515, China. Electronic address: maochen9@smu.edu.cn. FAU - Zhu, Bofeng AU - Zhu B AD - Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, 510515, China. Electronic address: zhubofeng@i.smu.edu.cn. LA - eng PT - Journal Article DEP - 20260417 PL - England TA - J Forensic Leg Med JT - Journal of forensic and legal medicine JID - 101300022 SB - IM MH - Humans MH - *Age Determination by Skeleton/methods MH - Female MH - *Bone Density MH - Aged, 80 and over MH - Child MH - Absorptiometry, Photon MH - Adolescent MH - Middle Aged MH - Aged MH - Adult MH - Retrospective Studies MH - Male MH - Young Adult MH - Body Mass Index MH - Boosting Machine Learning Algorithms MH - Random Forest MH - Linear Models MH - Ulna/diagnostic imaging MH - Radius/diagnostic imaging MH - *Machine Learning MH - Osteoporosis MH - Forensic Anthropology MH - Bayes Theorem MH - *Metadata MH - Support Vector Machine OTO - NOTNLM OT - Age estimation OT - Bone mineral density OT - Dual-energy X-ray absorptiometry OT - Forensic anthropology OT - Machine learning COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/07 00:33 MHDA- 2026/05/31 05:33 CRDT- 2026/05/06 18:08 PHST- 2025/09/14 00:00 [received] PHST- 2025/12/25 00:00 [revised] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/05/31 05:33 [medline] PHST- 2026/05/07 00:33 [pubmed] PHST- 2026/05/06 18:08 [entrez] AID - S1752-928X(26)00081-8 [pii] AID - 10.1016/j.jflm.2026.103149 [doi] PST - ppublish SO - J Forensic Leg Med. 2026 May;120:103149. doi: 10.1016/j.jflm.2026.103149. Epub 2026 Apr 17. PMID- 42090695 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1678-8060 (Electronic) IS - 0074-0276 (Print) IS - 0074-0276 (Linking) VI - 121 DP - 2026 TI - A non-destructive image-based approach to quantify blood meal size in Lutzomyia longipalpis (Diptera: Psychodidae). PG - e250158 LID - S0074-02762026000105029 [pii] LID - 10.1590/0074-02760250158 [doi] LID - e250158 AB - BACKGROUND: Phlebotomine sand flies are hematophagous vectors of major human pathogens, including Leishmania spp., with blood ingestion essential for reproduction and vector competence. Accurate quantification of blood meal volume is crucial for understanding physiological processes and transmission dynamics. OBJECTIVES: Here, we introduce a novel, non-destructive image-based method to estimate blood intake in Lutzomyia longipalpis, the principal vector of Leishmania infantum in the Americas. METHODS: High-resolution images of unfed and blood-fed females were analysed using Fiji ImageJ (open-source software) when several morphometric parameters were measured and validated against biochemical haemoglobin (Hb) quantification. FINDINGS: Blood-fed females exhibited a 56.6% increase in abdominal width and a shift toward a rounded body shape, which was strongly correlated with a visible transilluminated abdominal area (R(2) = 0.92). Some parameters, such as mean grey value and abdominal length, showed a low to moderate correlation with Hb content (R < 0.60). However, the correlation with abdominal area and width was R approximately 0.90, indicating those are reliable parameters that can be used to estimate blood intake by Lu. longipalpis females. MAIN CONCLUSIONS: Unlike spectrophotometric methods, this approach preserves specimen integrity, which, in theory, enables longitudinal studies on physiology and host-parasite interactions. This methodology offers a reliable, scalable, and cost-effective alternative for estimating blood meal. FAU - Costa, Lidiane Medeiros da AU - Costa LMD AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. FAU - Sant'Anna, Mauricio Roberto Viana AU - Sant'Anna MRV AUID- ORCID: 0000-0002-2504-0979 AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. FAU - Generoso, Laura Aquino AU - Generoso LA AD - Pontificia Universidade Catolica de Minas Gerais, Belo Horizonte, MG, Brasil. FAU - Cruz, Geisler Peixoto da AU - Cruz GPD AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. FAU - Pessoa, Grasielle Caldas D'Avila AU - Pessoa GCD AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Entomologia Medica, Belo Horizonte, MG, Brasil. FAU - Araujo, Ricardo Nascimento AU - Araujo RN AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Artropodes Hematofagos, Belo Horizonte, MG, Brasil. FAU - Gontijo, Nelder de Figueiredo AU - Gontijo NF AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. FAU - Pereira, Marcos Horacio AU - Pereira MH AUID- ORCID: 0000-0003-4843-0088 AD - Universidade Federal de Minas Gerais, Instituto de Ciencias Biologicas, Departamento de Parasitologia, Laboratorio de Fisiologia de Insetos Hematofagos, Belo Horizonte, MG, Brasil. LA - eng PT - Journal Article DEP - 20260501 PL - Brazil TA - Mem Inst Oswaldo Cruz JT - Memorias do Instituto Oswaldo Cruz JID - 7502619 RN - 0 (Hemoglobins) SB - IM MH - Animals MH - *Psychodidae/physiology/anatomy & histology MH - Female MH - *Feeding Behavior/physiology MH - *Insect Vectors/physiology/anatomy & histology MH - *Image Processing, Computer-Assisted/methods MH - Hemoglobins/analysis PMC - PMC13143169 COIS- The authors declare that they have no conflict of interest. EDAT- 2026/05/06 18:32 MHDA- 2026/05/06 18:33 PMCR- 2026/05/01 CRDT- 2026/05/06 16:23 PHST- 2025/06/24 00:00 [received] PHST- 2026/01/22 00:00 [accepted] PHST- 2026/05/06 18:33 [medline] PHST- 2026/05/06 18:32 [pubmed] PHST- 2026/05/06 16:23 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - S0074-02762026000105029 [pii] AID - 10.1590/0074-02760250158 [doi] PST - epublish SO - Mem Inst Oswaldo Cruz. 2026 May 1;121:e250158. doi: 10.1590/0074-02760250158. eCollection 2026. PMID- 42090600 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261019 IS - 1748-3115 (Electronic) IS - 1748-3107 (Linking) VI - 21 IP - 7 DP - 2026 Oct TI - Impact of adapted folk games on activity and participation in individuals with cerebral palsy - an exploratory proof of concept study. PG - 3758-3771 LID - 10.1080/17483107.2026.2667442 [doi] AB - PURPOSE: This exploratory study aimed to evaluate the feasibility and preliminary impact of adapted traditional Indian folk games on physical activity (PA) and participation in individuals with cerebral palsy (CP) in low-resource settings. MATERIALS AND METHODS: A two-phase exploratory design was employed. Phase I involved the systematic adaptation of traditional games (e.g. THOTTATUM, GUTTE) using the CHANGE IT framework, tailoring equipment and rules to functional levels (GMFCS I-IV). In Phase II, 36 participants with CP (GMFCS I-IV) underwent a structured intervention using these adapted games. Outcome measures included are Brockport Physical Fitness [BPFT], Gross Motor Function Measure 88 and a functional HRQoL questionnaire covering physical, emotional, social, and school domains. RESULTS: Post-intervention analysis of the total cohort showed significant improvements in handgrip strength and skinfold measurement. Significant positive shifts were observed in HRQoL domains, specifically physical (p < 0.05), emotional (p < 0.05), and school functioning. Qualitative feedback from parents and teachers corroborated these findings, noting improved activities of daily living (e.g. buttoning, brushing) and social interaction. Subgroup analysis indicated that while all levels benefitted, those at GMFCS Levels I-III showed the most pronounced gains in motor-related tasks. CONCLUSIONS: Adapted traditional folk games serve as a feasible, culturally relevant, and cost-effective form of assistive technology and rehabilitation. This approach effectively bridges the gap in accessible physical education for individuals with CP in Low and Middle Income Countries (LMIC's), providing a scalable model for inclusive activity and participation. FAU - Rahman A, Mansoor AU - Rahman A M AD - Department of Physiotherapy, SRM College of Physiotherapy, SRM University Tiruchirappalli Campus, Tiruchirappalli, Tamil Nadu, India. FAU - Kumar, Jagadish AU - Kumar J AD - Department of Paediatrics, JSS Medical College and Hospital, Mysuru, Karnataka, India. FAU - Raja, Kavitha AU - Raja K AUID- ORCID: 0000-0001-8787-2079 AD - Department of Physiotherapy, JSS College of Physiotherapy, Mysuru, Karnataka, India. LA - eng PT - Journal Article DEP - 20260506 PL - England TA - Disabil Rehabil Assist Technol JT - Disability and rehabilitation. Assistive technology JID - 101255937 SB - IM MH - Humans MH - *Cerebral Palsy/rehabilitation MH - Male MH - Female MH - Child MH - Adolescent MH - Activities of Daily Living MH - Hand Strength MH - Proof of Concept Study MH - Quality of Life MH - *Games, Recreational MH - *Exercise MH - Feasibility Studies MH - Adult MH - Surveys and Questionnaires OAB - Low-Cost Clinical Intervention: Adapted traditional folk games provide a cost-effective, culturally familiar method to enhance activity and participation in individuals with cerebral palsy. This approach is particularly valuable in low-resource settings where expensive specialised exercise equipment and high-tech assistive devices are often inaccessible.Systematic Adaptation Framework: The study provides a structured framework (using the CHANGE IT model) for clinicians to adapt traditional games of various geographical origins. By modifying game rules, equipment (e.g., adaptive stone moulds), and environments (e.g., wheelchair-integrated boards), rehabilitation professionals can tailor culturally relevant activities to match a participant's specific functional level (GMFCS I-IV).Social and Educational Integration: These adapted games facilitate inclusive physical education and social bonding, as evidenced by improved HRQoL in physical, emotional, and academic domains. This model supports the integration of rehabilitation goals into daily school curricula and community life, fostering social participation alongside motor improvement. OABL- eng OTO - NOTNLM OT - Cerebral palsy OT - activity OT - adaptive sports OT - games OT - participation OT - traditional games EDAT- 2026/05/06 18:32 MHDA- 2026/10/19 17:31 CRDT- 2026/05/06 15:23 PHST- 2026/10/19 17:31 [medline] PHST- 2026/05/06 18:32 [pubmed] PHST- 2026/05/06 15:23 [entrez] AID - 10.1080/17483107.2026.2667442 [doi] PST - ppublish SO - Disabil Rehabil Assist Technol. 2026 Oct;21(7):3758-3771. doi: 10.1080/17483107.2026.2667442. Epub 2026 May 6. PMID- 42089393 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260908 IS - 1532-7795 (Electronic) IS - 1050-8392 (Print) IS - 1050-8392 (Linking) VI - 36 IP - 2 DP - 2026 Jun TI - Understanding sleep and smartphone use in diverse adolescents through passive digital monitoring. PG - e70192 LID - 10.1111/jora.70192 [doi] LID - e70192 AB - Adolescents are among the most frequent smartphone users worldwide. Yet, few studies have examined how smartphone use appears among minority adolescents, including sexual and gender minority (SGM) youth and children of immigrant parents, who often experience unique stressors and heightened mental-health risk. Passive smartphone monitoring provides a promising, low-burden method for continuously and objectively assessing real-world behavior, offering new opportunities to identify dynamic markers of mental health challenges, including suicide risk, in daily life. The present study evaluated the feasibility of a replicable framework for passive smartphone monitoring among adolescents at high risk for suicidal thoughts and behaviors (STB) and explored longitudinal differences in smartphone-derived behavioral features across minority subgroups. Ninety-nine adolescents aged 11-18 with recent STB completed baseline assessments and installed the iFeel app, which collected passive smartphone data for 6 months, including total and social-media screen time and phone-inactivity-based proxy sleep indicators inferred from nighttime phone inactivity. Participants contributed 1500 participant-weeks of data, with an average of 11.9 weeks of valid monitoring, supporting the feasibility and acceptability of this approach. Daily smartphone use time, social-media activity time, and sleep duration were comparable to normative adolescent data. No significant longitudinal differences emerged between SGM and non-SGM adolescents. However, immigrant-origin adolescents displayed shorter but more stable sleep patterns compared to non-immigrant origins, who exhibited longer baseline sleep with steeper declines over time. Findings highlight passive sensing as a feasible, inclusive, and scalable method for examining real-world behavioral processes associated with STB and mental health outcomes among diverse adolescents. This framework offers a scalable approach that future studies can apply to deepen real-time understanding of mental-health challenges and behavioral patterns among diverse adolescents. CI - (c) 2026 The Author(s). Journal of Research on Adolescence published by Wiley Periodicals LLC on behalf of Society for Research on Adolescence. FAU - Shahnovsky, Oren AU - Shahnovsky O AUID- ORCID: 0009-0001-4225-205X AD - Department of Community Mental Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel. AD - Department of Child and Adolescent Psychiatry, Schneider Children's Medical Center of Israel, Petah Tikvah, Israel. FAU - Ekstein, Daniella AU - Ekstein D AUID- ORCID: 0000-0002-3674-0786 AD - Department of Community Mental Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel. FAU - Friedman, Talia AU - Friedman T AD - Data Science Institute, Reichman University, Herzliya, Israel. FAU - Stemmer, Maya AU - Stemmer M AD - Data Science Institute, Reichman University, Herzliya, Israel. FAU - Carmi, Lior AU - Carmi L AD - Data Science Institute, Reichman University, Herzliya, Israel. FAU - Benaroya-Milshtein, Noa AU - Benaroya-Milshtein N AD - Department of Child and Adolescent Psychiatry, Schneider Children's Medical Center of Israel, Petah Tikvah, Israel. AD - Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel-Aviv, Israel. FAU - Fine, Shai AU - Fine S AD - Data Science Institute, Reichman University, Herzliya, Israel. FAU - Barzilay, Shira AU - Barzilay S AUID- ORCID: 0000-0002-4026-6204 AD - Department of Community Mental Health, Faculty of Social Welfare and Health Sciences, University of Haifa, Haifa, Israel. LA - eng GR - Graduate Studies Authority and Bloom School for Graduate Studies, University of Haifa/ GR - Bishvil Hahayim (R.A.) Association/ GR - Data Science Institute, Reichman University/ GR - Lior Zfati Center for Suicide and Mental Pain Research/ GR - 3-15289/Ministry of Science and Technology, Israel/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Res Adolesc JT - Journal of research on adolescence : the official journal of the Society for Research on Adolescence JID - 9109126 SB - IM MH - Humans MH - Adolescent MH - *Smartphone/statistics & numerical data MH - Female MH - Male MH - *Sleep MH - *Adolescent Behavior/psychology MH - Child MH - Suicidal Ideation MH - *Sexual and Gender Minorities/psychology/statistics & numerical data MH - Screen Time MH - Feasibility Studies MH - Emigrants and Immigrants/psychology/statistics & numerical data MH - Mobile Applications PMC - PMC13147491 OTO - NOTNLM OT - adolescents OT - minority populations OT - passive sensing OT - passive smartphone monitoring OT - suicide COIS- No potential conflict of interest was reported by the author(s). EDAT- 2026/05/06 12:34 MHDA- 2026/05/06 12:35 PMCR- 2026/05/06 CRDT- 2026/05/06 06:54 PHST- 2025/11/01 00:00 [received] PHST- 2026/04/17 00:00 [accepted] PHST- 2026/05/06 12:35 [medline] PHST- 2026/05/06 12:34 [pubmed] PHST- 2026/05/06 06:54 [entrez] PHST- 2026/05/06 00:00 [pmc-release] AID - JORA70192 [pii] AID - 10.1111/jora.70192 [doi] PST - ppublish SO - J Res Adolesc. 2026 Jun;36(2):e70192. doi: 10.1111/jora.70192. PMID- 42088677 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260506 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Translation, cross-cultural adaptation and psychometric validation of the self-efficacy scale for physical education teacher education majors toward children with disabilities for Brazilian Portuguese. PG - 1782205 LID - 10.3389/fpsyg.2026.1782205 [doi] LID - 1782205 AB - INTRODUCTION: The participation of people with disabilities (PWD) in physical activity and sports is essential for social inclusion and health promotion. The self-efficacy perceived by professionals greatly influences the success of inclusive practices; higher confidence in adapting activities and addressing diverse needs leads to better experiences for PWD. The self-efficacy scale for physical education teacher education majors toward children with disabilities (SE-PETE-D) measures this construct but lacked a validated Brazilian version. OBJECTIVE: To translate, culturally adapt, and validate the Brazilian Portuguese version, named EAE-EFI/Brazil. RESULTS: Content validity indices exceeded 0.90 across all subscales. Exploratory factor analysis revealed high internal consistency (Cronbach's alpha > 0.96). Confirmatory factor analysis showed acceptable model fit (RMSEA <0.10; CFI, TLI, IFI > 0.90), supporting the original structure for subscales related to physical disability (PD) and visual impairment (VI). CONCLUSION: The EAE-EFI/Brazil is a valid and reliable tool for assessing physical education teachers' and students' self-efficacy concerning inclusion of individuals with intellectual disabilities, PD, and VI in Brazil. Future studies should evaluate the scale's applicability in diverse contexts and explore links with professional development and institutional support, advancing inclusive practices and policies in Brazilian education. CI - Copyright (c) 2026 Guerreiro, Winckler, Almeida, Block and Silva. FAU - Guerreiro, Renato de Carvalho AU - Guerreiro RC AD - Universidade Federal de Juiz de Fora - UFJF, Governador Valadares, Brazil. AD - Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil. AD - Comite Paralimpico Brasileiro, Sao Paulo, Brazil. FAU - Winckler, Ciro AU - Winckler C AD - Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil. FAU - de Almeida, Raphael Moreira AU - de Almeida RM AD - Universidade Federal de Sao Paulo - UNIFESP, Sao Paulo, Brazil. FAU - Block, Martin E AU - Block ME AD - University of Virginia, Charlottesville, VA, United States. FAU - Silva, Andressa AU - Silva A AD - Universidade Federal de Minas Gerais - UFMG, Belo Horizonte, Brazil. LA - eng PT - Journal Article DEP - 20260420 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13136146 OTO - NOTNLM OT - EAE-EFI/Brazil OT - SE-PETE-D OT - cross-cultural adaptation OT - inclusive physical education OT - physical education teacher OT - professional development OT - self-efficacy scale OT - special educational needs COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/06 06:37 MHDA- 2026/05/06 06:38 PMCR- 2026/04/20 CRDT- 2026/05/06 05:03 PHST- 2026/01/06 00:00 [received] PHST- 2026/03/22 00:00 [revised] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/05/06 06:38 [medline] PHST- 2026/05/06 06:37 [pubmed] PHST- 2026/05/06 05:03 [entrez] PHST- 2026/04/20 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1782205 [doi] PST - epublish SO - Front Psychol. 2026 Apr 20;17:1782205. doi: 10.3389/fpsyg.2026.1782205. eCollection 2026. PMID- 42088379 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260506 LR - 20260813 IS - 2768-2765 (Electronic) IS - 2768-2765 (Linking) VI - 15 DP - 2026 May TI - Cardiopulmonary Consequences of Scoliosis and the Clinical Implications of VO(2)max: A Systematic Review. PG - 100369 LID - 10.1016/j.jposna.2026.100369 [doi] LID - 100369 AB - INTRODUCTION: Multiple parameters, including VO(2)max, ventilatory efficiency, lung volumes, and exercise tolerance, have been examined, yet their progression with pediatric scoliosis remains unclear. Although pulmonary function tests are widely used, they may underestimate functional impairment, as spirometric measures can remain relatively preserved despite clinically meaningful reductions in exercise capacity. This review aims to define the extent of functional impairment, its association with curve severity, and the potential of VO(2)max as a marker of surgical recovery. MATERIALS AND METHODS: We systematically searched PubMed, Embase, and Cochrane for eligible studies reporting cardiopulmonary outcomes in pediatric scoliosis. Risk of bias was assessed using the Joanna Briggs Institute critical appraisal tools and the ROBINS-I risk-of-bias tool. Results were synthesized narratively following the Synthesis Without Meta-analysis guideline. CONCLUSIONS: From 455 records, 6 studies met the inclusion criteria. Adolescents with idiopathic scoliosis consistently demonstrated reduced aerobic capacity, with mean VO(2)max values ranging from 27.9 to 33.6 mL kg(-1).min(-1), approximately 20-25% below reference norms, indicating mild-to-moderate cardiopulmonary impairment. Functional tests such as the 6-min walk and E-fit correlated strongly with VO(2)max, validating their use as practical surrogates of aerobic performance. Greater curve severity and thoracic deformity were associated with progressive reductions in forced expiratory volume in one second, forced vital capacity, and VO(2)max, reflecting restrictive ventilatory physiology. Postoperative studies showed stable but not improved VO(2) or pulmonary function, suggesting that surgery preserves rather than enhances respiratory capacity. Exercise-based rehabilitation improved posture and endurance, though effects on VO(2)max remain inconclusive.A spectrum of cardiopulmonary parameters deteriorates with scoliosis progression. VO(2) max may provide the most integrative marker of physiological burden, and prospective longitudinal data are required to establish its role in recovery after surgery. KEY CONCEPT: (1)Adolescents with scoliosis exhibit clinically meaningful reductions in cardiopulmonary reserve, which may not be apparent on resting spirometry but become evident during exercise and directly influence perioperative physiological resilience.(2)Radiographic measures of deformity correction do not reliably reflect functional recovery, underscoring the limitations of relying on Cobb angle and pulmonary function tests alone when assessing surgical readiness and postoperative outcomes.(3)Cardiopulmonary exercise testing (CPET) provides an objective, integrative assessment of surgical fitness, allowing differentiation between ventilatory, cardiovascular, and peripheral contributors to exercise limitation, with VO(2)max serving as a robust summary metric.(4)Corrective scoliosis surgery appears to preserve rather than restore cardiopulmonary function, suggesting that preoperative physiological status may be a key determinant of postoperative recovery trajectory and length of convalescence.(5)Incorporation of VO(2)max into preoperative assessment and Enhanced Recovery After Surgery pathways may enhance risk stratification, inform prehabilitation strategies, and guide postoperative rehabilitation, enabling more individualized perioperative care for children and adolescents undergoing scoliosis surgery. CI - (c) 2026 The Author(s). FAU - Sharma, Suhani AU - Sharma S AD - School of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland. FAU - Ramnarine, Arun AU - Ramnarine A AD - School of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland. FAU - Fouad, Karim AU - Fouad K AD - School of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland. FAU - Kirby, Samuel AU - Kirby S AD - School of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland. FAU - Sankar, Shreya AU - Sankar S AD - School of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland. FAU - O'Connor, Michael AU - O'Connor M AD - School of Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland. FAU - O'Byrne, George-Paul AU - O'Byrne GP AD - Department of Surgery, University Hospital Limerick, Limerick, Ireland. FAU - Boughton, Oliver AU - Boughton O AD - Scoliosis Academy, CHI Crumlin, Dublin, Ireland. FAU - Kiely, Patrick AU - Kiely P AD - Scoliosis Academy, CHI Crumlin, Dublin, Ireland. FAU - Rafferty, Tony AU - Rafferty T AD - Scoliosis Academy, CHI Crumlin, Dublin, Ireland. LA - eng PT - Journal Article PT - Review DEP - 20260402 PL - United States TA - J Pediatr Soc North Am JT - Journal of the Pediatric Orthopaedic Society of North America JID - 101776896 PMC - PMC13138236 OTO - NOTNLM OT - Adolescent idiopathic scoliosis OT - Cardiopulmonary exercise testing OT - VO2max COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/06 06:37 MHDA- 2026/05/06 06:38 PMCR- 2026/04/02 CRDT- 2026/05/06 04:59 PHST- 2026/01/11 00:00 [received] PHST- 2026/03/12 00:00 [revised] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/05/06 06:38 [medline] PHST- 2026/05/06 06:37 [pubmed] PHST- 2026/05/06 04:59 [entrez] PHST- 2026/04/02 00:00 [pmc-release] AID - S2768-2765(26)00048-9 [pii] AID - 100369 [pii] AID - 10.1016/j.jposna.2026.100369 [doi] PST - epublish SO - J Pediatr Soc North Am. 2026 Apr 2;15:100369. doi: 10.1016/j.jposna.2026.100369. eCollection 2026 May. PMID- 42087872 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Steroid hormones in early pregnancy and adverse birth outcomes: a Chinese birth cohort. PG - 1667039 LID - 10.3389/fendo.2026.1667039 [doi] LID - 1667039 AB - BACKGROUND: Adverse birth outcomes (ABOs) are major public health concerns. While maternal steroid hormones are essential for fetal development, their individual and combined effects on ABO remain unclear. METHODS: This prospective cohort study included 364 pregnant women (30.7 +/- 4.0 years) in Guangzhou, China. Nineteen steroid hormones were measured by LC-MS/MS. Regression and Qgcomp models were used to assess individual and combined associations with ABO, including low birth weight, macrosomia, small for gestational age (SGA), large for gestational age, and preterm birth. RESULTS: Pregnant women with ABO had higher levels of androstenedione (A4) and testosterone (T) and lower levels of 11-deoxycortisol (11-DOF) and estriol (E3). In linear regression models, each 1-SD increase in cortisol (F) was associated with increases of 0.18 cm (95% CI: 0.02, 0.34) in birth length and 0.24 cm (95% CI: 0.04, 0.44) in head circumference, whereas estrone (E1) was inversely associated with gestational age (-0.20 weeks, 95% CI: -0.36, -0.05). In logistic regression analyses, each 1-SD increase in A4 (OR = 1.36, 95% CI: 1.07, 1.72), T (OR = 1.37, 95% CI: 1.08, 1.73), and dihydrotestosterone (DHT) (OR = 1.32, 95% CI: 1.03, 1.69) was associated with higher odds of ABO, whereas 11-DOF was inversely associated with ABO (OR = 0.70, 95% CI: 0.50, 0.98). For SGA, each 1-SD increase in A4 (OR = 1.40, 95% CI: 1.01, 1.94) and T (OR = 1.47, 95% CI: 1.08, 1.99) was associated with increased risk, whereas F (OR = 0.84, 95% CI: 0.72, 0.97) and 11-DOF (OR = 0.58, 95% CI: 0.35, 0.95) were inversely associated. In Qgcomp analyses, the androgen mixture was associated with ABO (OR = 1.40, 95% CI: 1.00, 1.97) and SGA (OR = 1.77, 95% CI: 1.04, 3.01), with A4 and T contributing the largest weights. Consistent directional patterns were observed for androgen-related hormones across outcomes and analytical approaches. CONCLUSIONS: Maternal hormonal milieu in early pregnancy may be associated with fetal growth and ABO risk, with consistent patterns for androgen-related hormones. These findings are exploratory and require validation in larger cohorts. CI - Copyright (c) 2026 Wu, Ji, Li, Diao, Wu, Ruan, Luo and Luo. FAU - Wu, Weixiang AU - Wu W AD - Department of Clinical Laboratory, Women and Children's Hospital, Southern University of Science and Technology, Guangzhou, China. AD - Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China. FAU - Ji, Cunwei AU - Ji C AD - Department of Clinical Laboratory, Women and Children's Hospital, Southern University of Science and Technology, Guangzhou, China. AD - Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China. FAU - Li, Hongyu AU - Li H AD - Department of Clinical Laboratory, Women and Children's Hospital, Southern University of Science and Technology, Guangzhou, China. AD - Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China. FAU - Diao, Fuqiang AU - Diao F AD - Department of Clinical Laboratory, Women and Children's Hospital, Southern University of Science and Technology, Guangzhou, China. AD - Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China. FAU - Wu, Lihong AU - Wu L AD - Department of Clinical Laboratory, Women and Children's Hospital, Southern University of Science and Technology, Guangzhou, China. AD - Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China. FAU - Ruan, Xiaolin AU - Ruan X AD - Department of Clinical Laboratory, Women and Children's Hospital, Southern University of Science and Technology, Guangzhou, China. AD - Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China. FAU - Luo, Youwen AU - Luo Y AD - Department of Clinical Laboratory, Women and Children's Hospital, Southern University of Science and Technology, Guangzhou, China. AD - Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China. FAU - Luo, Mingyong AU - Luo M AD - Department of Clinical Laboratory, Women and Children's Hospital, Southern University of Science and Technology, Guangzhou, China. AD - Department of Clinical Laboratory, Guangdong Women and Children Hospital, Guangzhou, China. LA - eng PT - Journal Article DEP - 20260420 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 409J2J96VR (Androstenedione) RN - 3XMK78S47O (Testosterone) RN - Chinese people SB - IM MH - Adult MH - Female MH - Humans MH - Infant, Newborn MH - Pregnancy MH - Androstenedione/blood MH - Birth Cohort MH - Birth Weight MH - China/epidemiology MH - Infant, Large for Gestational Age MH - Infant, Low Birth Weight MH - Infant, Small for Gestational Age MH - *Pregnancy Outcome/epidemiology MH - *Premature Birth/epidemiology/blood MH - Prospective Studies MH - Testosterone/blood MH - East Asian People PMC - PMC13135977 OTO - NOTNLM OT - adverse birth outcomes OT - androgen OT - androstenedione OT - combined effect OT - steroid hormones OT - testosterone COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/06 06:40 MHDA- 2026/05/06 06:41 PMCR- 2026/04/20 CRDT- 2026/05/06 04:54 PHST- 2025/07/16 00:00 [received] PHST- 2026/03/21 00:00 [revised] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/05/06 06:41 [medline] PHST- 2026/05/06 06:40 [pubmed] PHST- 2026/05/06 04:54 [entrez] PHST- 2026/04/20 00:00 [pmc-release] AID - 10.3389/fendo.2026.1667039 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Apr 20;17:1667039. doi: 10.3389/fendo.2026.1667039. eCollection 2026. PMID- 42087450 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260813 IS - 1651-2227 (Electronic) IS - 0803-5253 (Print) IS - 0803-5253 (Linking) VI - 115 IP - 9 DP - 2026 Sep TI - Early Transepidermal Water Loss in Term Neonates and Its Perinatal Influences Using a Closed-Chamber System. PG - 1923-1928 LID - 10.1111/apa.70583 [doi] AB - AIMS: To establish transepidermal water loss values on the first postnatal day in healthy term neonates and associations with perinatal factors utilising a closed-chamber system. METHODS: A cross-sectional single-centre study was conducted over a 7-month period. Healthy infants >/= 37-week gestation and 2-24 h old were recruited. Transepidermal water loss was measured at a single time-point, non-invasively under typical ambient conditions using a standardised approach. Anthropometric and perinatal variables were collated. Outcomes assessed included device validity and reliability, transepidermal water loss values, and interactions with maternal and infant variables. RESULTS: A total of 120 term infants were recruited. The intra-class correlation coefficient of three consecutive readings was 0.735, indicating good reliability. There was no interaction between transepidermal water loss and ambient conditions. Mean values were 13.9 +/- 3.28 g/m(2)/h. The 5th and 95th percentiles were 9.7 and 20.3 g/m(2)/h, respectively. Each additional postnatal hour conferred a reduction in transepidermal water loss of 0.11 g/m(2)/h. Caesarean section increased transepidermal losses by 1.4 g/m(2)/h. No other associations were significant. CONCLUSION: Early postnatal transepidermal water loss in the term infant is low but variable. Physiological variability is not attributable to typical ambient conditions or common perinatal factors, indicating a uniformly competent skin barrier at term. CI - (c) 2026 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd. FAU - McGrath, Colin P AU - McGrath CP AUID- ORCID: 0000-0002-3440-4391 AD - Department of Neonatology, The Rotunda Hospital, Dublin, Ireland. FAU - Boyle, Michael A AU - Boyle MA AD - Department of Neonatology, The Rotunda Hospital, Dublin, Ireland. AD - Department of Paediatrics, RCSI University of Medicine & Health Sciences, Dublin, Ireland. LA - eng GR - The Rotunda Foundation/ PT - Journal Article DEP - 20260505 PL - Norway TA - Acta Paediatr JT - Acta paediatrica (Oslo, Norway : 1992) JID - 9205968 SB - IM MH - Humans MH - *Water Loss, Insensible MH - Female MH - Infant, Newborn MH - Cross-Sectional Studies MH - Male PMC - PMC13460648 OTO - NOTNLM OT - Transepidermal water loss OT - closed-chamber device OT - non-invasive measurement OT - skin integrity COIS- The authors declare no conflicts of interest. EDAT- 2026/05/06 06:40 MHDA- 2026/08/11 17:36 PMCR- 2026/08/11 CRDT- 2026/05/06 01:43 PHST- 2026/04/10 00:00 [revised] PHST- 2026/02/26 00:00 [received] PHST- 2026/04/29 00:00 [accepted] PHST- 2026/08/11 17:36 [medline] PHST- 2026/05/06 06:40 [pubmed] PHST- 2026/05/06 01:43 [entrez] PHST- 2026/08/11 00:00 [pmc-release] AID - APA70583 [pii] AID - 10.1111/apa.70583 [doi] PST - ppublish SO - Acta Paediatr. 2026 Sep;115(9):1923-1928. doi: 10.1111/apa.70583. Epub 2026 May 5. PMID- 42086326 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260729 IS - 1536-4844 (Electronic) IS - 1078-0998 (Linking) VI - 32 IP - 8 DP - 2026 Aug 1 TI - Multi-omics-based machine learning model predicts response and guides treatment in Crohn disease: a case study in nutritional therapy. PG - 1513-1523 LID - 10.1093/ibd/izag060 [doi] AB - BACKGROUND: Biomarkers are needed to predict treatment response and guide therapeutic decisions in Crohn disease (CD). We aimed to develop and validate a multi-omics machine learning (ML) model to predict response to nutritional therapy in pediatric CD. METHODS: Treatment-naive children with newly diagnosed CD who were initiating exclusive enteral nutrition (EEN) were prospectively enrolled in this study. Metabolomics and lipidomics were measured in the serum and stool, as well as the fecal microbiome. Following feature selection via minimum redundancy maximum relevance, random-forest models were constructed for single- and multi-omics and performances were evaluated. The models were externally validated in an independent prospective cohort of treatment-naive children and young adults with CD treated with EEN. RESULTS: The discovery cohort consisted of 50 children (mean +/- SD age 14.3 +/- 2.7 years), of whom 34 (68%) responded to EEN. Combining complementary signals from host metabolism, gut microbiota, and lipid profiles from serum and stool in a multi-omics ML model yielded a model for predicting treatment response (training accuracy 94%; 95% CI, 82%-100%). Key predictive features included serum metabolites (2-hydroxyglutaric acid, Cer[d18:0/22:0], and HexCer[d18:1/d26:1]), fecal metabolites (3-methyladipic acid, DG[16:0 20:0], PC aa C42:2), and microbial taxa (family Bifidobacteriaceae and genus CAG-56). The validation cohort consisted of 21 patients of whom 12 (57%) responded to EEN. The multi-omics model performance achieved an area under the receiver operating characteristic curve (AUROC) of 0.81 (95% CI, 0.6-1.0). Clinical and endoscopic features did not improve the predictive ability of the model. CONCLUSION: As a proof-of-concept, we showed that integrated multi-omics ML models can predict EEN response in pediatric CD patients, supporting their potential use in precision nutrition and personalized care strategies. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Azulay, Asaf AU - Azulay A AUID- ORCID: 0000-0003-4952-3729 AD - Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem Israel. FAU - Gotesdyner, Leora AU - Gotesdyner L AD - Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem Israel. FAU - Aharoni-Frutkoff, Yonat AU - Aharoni-Frutkoff Y AD - Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem Israel. FAU - Focht, Gili AU - Focht G AD - Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem Israel. FAU - Talmor, Yael AU - Talmor Y AD - School of Computer Science, Tel Aviv University, Tel Aviv, Israel. FAU - Borenstein, Elhanan AU - Borenstein E AUID- ORCID: 0000-0003-3002-0945 AD - School of Computer Science, Tel Aviv University, Tel Aviv, Israel. AD - Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. AD - Santa Fe Institute, Santa Fe, NM, United States. FAU - Plotkin, Luba AU - Plotkin L AD - Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem Israel. FAU - Orlanski-Meyer, Esther AU - Orlanski-Meyer E AD - Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem Israel. FAU - Lev-Tzion, Raffi AU - Lev-Tzion R AD - Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem Israel. FAU - Ledder, Oren AU - Ledder O AUID- ORCID: 0000-0001-8109-814X AD - Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem Israel. FAU - Yogev, Dotan AU - Yogev D AD - Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem Israel. FAU - Assa, Amit AU - Assa A AD - Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem Israel. FAU - Broide, Efrat AU - Broide E AD - Pediatric Gastroenterology Unit, Assaf Harofeh Medical Center, Zerifin, Israel. FAU - Yerushalmy-Feler, Anat AU - Yerushalmy-Feler A AD - Pediatric Gastroenterology Institute, "Dana-Dwek" Children's Hospital, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel. AD - Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Kierkus, Jaroslaw AU - Kierkus J AD - Pediatric Gastroenterology Unit, Children's Memorial Health Institute, Warsaw, Poland. FAU - Schwerd, Tobias AU - Schwerd T AD - Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, LMU Munich, Germany. FAU - Wine, Eytan AU - Wine E AD - Division of Gastroenterology, Hepatology, and Nutrition, Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada. FAU - Turner, Dan AU - Turner D AUID- ORCID: 0000-0001-5160-868X AD - Juliet Keidan Institute of Pediatric Gastroenterology Hepatology and Nutrition, The Eisenberg R&D Authority, Shaare Zedek Medical Center, The Hebrew University of Jerusalem, Jerusalem Israel. LA - eng GR - Leona M. and Harry B. Helmsley Charitable Trust/ GR - academic grant from the International Organization of Inflammatory Bowel Diseases/ PT - Journal Article PL - England TA - Inflamm Bowel Dis JT - Inflammatory bowel diseases JID - 9508162 RN - 0 (Biomarkers) RN - Pediatric Crohn's disease SB - IM CIN - Inflamm Bowel Dis. 2026 Aug 1;32(8):1661-1662. doi: 10.1093/ibd/izag087. PMID: 42133586 CIN - Inflamm Bowel Dis. 2026 Aug 1;32(8):1652-1654. doi: 10.1093/ibd/izag081. PMID: 42143678 MH - Humans MH - *Crohn Disease/therapy/metabolism MH - Multiomics MH - *Machine Learning MH - Female MH - Adolescent MH - Male MH - *Enteral Nutrition/methods MH - Predictive Learning Models MH - Child MH - Biomarkers/analysis MH - Metabolomics/methods MH - Prospective Studies MH - Feces/microbiology/chemistry MH - Gastrointestinal Microbiome MH - Treatment Outcome OAB - This study developed and externally validated a multi-omics machine-learning model integrating serum and fecal metabolomics, lipidomics, and microbiome data to predict pediatric Crohn disease response to exclusive enteral nutrition, achieving high accuracy. This study advances personalized medicine in pediatric IBD. OABL- eng OTO - NOTNLM OT - Children OT - Crohn disease OT - Exclusive enteral nutrition OT - Metabolomics OT - Microbiome OT - Multiomics OT - Nutritional therapy OT - Prediction EDAT- 2026/05/06 00:33 MHDA- 2026/07/29 18:38 CRDT- 2026/05/05 21:13 PHST- 2025/08/28 00:00 [received] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/07/29 18:38 [medline] PHST- 2026/05/06 00:33 [pubmed] PHST- 2026/05/05 21:13 [entrez] AID - 8669993 [pii] AID - 10.1093/ibd/izag060 [doi] PST - ppublish SO - Inflamm Bowel Dis. 2026 Aug 1;32(8):1513-1523. doi: 10.1093/ibd/izag060. PMID- 42086291 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2054-4774 (Print) IS - 2054-4774 (Electronic) IS - 2054-4774 (Linking) VI - 13 IP - 1 DP - 2026 May 5 TI - Transarterial chemoembolisation-based combination therapy as a potential new standard for intermediate-stage hepatocellular carcinoma in the targeted immunotherapy era. LID - 10.1136/bmjgast-2025-002154 [doi] LID - e002154 AB - Transarterial chemoembolisation (TACE) is the standard therapy for intermediate-stage hepatocellular carcinoma (HCC); however, its efficacy is limited by significant tumour heterogeneity. Recent landmark trials (EMERALD-1 and LEAP-012) demonstrated that adding targeted immunotherapy to TACE significantly improves progression-free survival compared with TACE alone. However, the inconsistent overall survival (OS) benefit, particularly in LEAP-012, highlights the necessity for precision patient stratification. Key determinants of outcomes include tumour burden, liver function, microvascular invasion (MVI), systemic inflammation, immune status and comorbidities. For patients with low tumour burden, optimised locoregional therapies can achieve higher complete response rates. For high tumour burden, multimodal strategies are required, with increasing evidence supporting TACE plus targeted therapy with or without immunotherapy. MVI-positive HCC derives added benefit from adjuvant tyrosine kinase inhibitors (TKIs) after TACE, while dynamic liver function monitoring is crucial for safety, especially in patients with Child-Pugh B. Future directions should focus on developing and validating robust multidimensional stratification models. These models should integrate key established determinants-such as tumour burden, liver function reserve, MVI, systemic inflammatory/immune status, alpha-fetoprotein (AFP) and comorbidities-with promising emerging biomarkers (eg, circulating tumour DNA). Concurrent efforts are needed to optimise combination regimens and conduct health-economic evaluations. Global collaboration and cost-effectiveness analyses are essential to prioritise high-benefit subgroups (eg, those with high tumour burden, MVI positivity and/or mild inflammation, active immune status alongside preserved liver function and limited comorbidities) for intensive combination therapy while avoiding overtreatment in lower-benefit populations. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Chen, Shuanggang AU - Chen S AD - Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. AD - State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. FAU - Shen, Lujun AU - Shen L AD - Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. AD - State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. FAU - Qi, Han AU - Qi H AD - Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. AD - State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. FAU - Hu, Pan AU - Hu P AD - Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. AD - State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. FAU - Cao, Fei AU - Cao F AD - Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. AD - State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. FAU - Xie, Lin AU - Xie L AD - Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. AD - State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. FAU - Wang, Yujia AU - Wang Y AD - Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. AD - State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. FAU - Fan, Weijun AU - Fan W AUID- ORCID: 0000-0002-8757-647X AD - Department of Minimally Invasive Interventional Therapy, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China fanwj@sysucc.org.cn. AD - State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China. LA - eng PT - Journal Article PT - Review DEP - 20260505 PL - England TA - BMJ Open Gastroenterol JT - BMJ open gastroenterology JID - 101660690 SB - IM MH - Humans MH - *Carcinoma, Hepatocellular/therapy/pathology/mortality MH - *Liver Neoplasms/therapy/pathology/mortality MH - *Chemoembolization, Therapeutic/methods MH - *Immunotherapy/methods MH - Combined Modality Therapy/methods MH - Neoplasm Staging MH - Treatment Outcome MH - Tumor Burden MH - Progression-Free Survival MH - Molecular Targeted Therapy/methods PMC - PMC13150888 OTO - NOTNLM OT - CANCER IMMUNOBIOLOGY OT - HEPATOCELLULAR CARCINOMA OT - IMMUNOLOGY OT - IMMUNOLOGY IN HEPATOLOGY COIS- Competing interests: None declared. EDAT- 2026/05/06 00:33 MHDA- 2026/05/06 00:34 PMCR- 2026/05/05 CRDT- 2026/05/05 20:52 PHST- 2025/10/29 00:00 [received] PHST- 2026/04/14 00:00 [accepted] PHST- 2026/05/06 00:34 [medline] PHST- 2026/05/06 00:33 [pubmed] PHST- 2026/05/05 20:52 [entrez] PHST- 2026/05/05 00:00 [pmc-release] AID - bmjgast-2025-002154 [pii] AID - 10.1136/bmjgast-2025-002154 [doi] PST - epublish SO - BMJ Open Gastroenterol. 2026 May 5;13(1):e002154. doi: 10.1136/bmjgast-2025-002154. PMID- 42086263 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 5 DP - 2026 May 5 TI - Comparing the Asia-Pacific Colorectal Screening and adjusted Asia-Pacific Colorectal Screening scores for risk stratification of advanced colorectal neoplasia in asymptomatic Vietnamese: a cross-sectional study. PG - e102941 LID - 10.1136/bmjopen-2025-102941 [doi] LID - e102941 AB - OBJECTIVE: The Asia-Pacific Colorectal Screening (APCS) score is a validated tool for predicting advanced colorectal neoplasia (ACN) in the Asia-Pacific region. An adjusted APCS (A-APCS) score was recently developed by incorporating body mass index into the original score and was reported to outperform the original score but lacked external validation. This study aimed to compare the A-APCS score with the original APCS score in asymptomatic Vietnamese individuals. DESIGN: A cross-sectional study. SETTING: Dai Phuoc Polyclinic, Ho Chi Minh City, Vietnam. PARTICIPANTS: Asymptomatic individuals underwent colonoscopy screening. OUTCOME MEASURES: Participants were categorised into three risk groups based on the sum of the APCS and A-APCS scores: average risk (AR), moderate risk (MR) and high risk (HR). The performance of the two scores was compared via receiver operating characteristic (ROC) analysis and McNemar tests. RESULTS: A total of 714 participants (median age 51 years, range: 18-79; female-to-male ratio: 1:1.46) were included, with an ACN prevalence of 9.0%. Both scores indicated effective predictive ability for ACN in the HR group compared with the AR group, with OR=3.878 (95% CI 1.777 to 8.068) and 3.266 (95% CI 1.617 to 6.595), respectively. The A-APCS score was more effective than the APCS score in predicting ACN in the MR group than in the AR group. However, no significant differences in area under the ROC curve were observed between the two scores for ACN prediction. CONCLUSIONS: Compared with the APCS score, the A-APCS score may not provide improved ACN risk stratification in asymptomatic Vietnamese individuals. Both scores are suboptimal and should be used to prioritise, rather than exclude, candidates for colonoscopy. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Quach, Duc Trong AU - Quach DT AUID- ORCID: 0000-0003-0141-921X AD - Department of Internal Medicine and Gastro-Hepato Integrated Research Team (GHIRT-002.TCM2025), University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam drquachtd@gmail.com. AD - Department of Gastroenterology, Nhan Dan Gia Dinh Hospital, Ho Chi Minh City, Viet Nam. FAU - Vu, Nhu Thi Hanh AU - Vu NTH AUID- ORCID: 0000-0003-4208-7813 AD - Department of Internal Medicine and Gastro-Hepato Integrated Research Team (GHIRT-002.TCM2025), University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam. FAU - To, Huong Thi Thuy AU - To HTT AD - Dai Phuoc Polyclinic, Ho Chi Minh City, Viet Nam. FAU - Tong, Hong Nguyen Diem AU - Tong HND AD - Dai Phuoc Polyclinic, Ho Chi Minh City, Viet Nam. FAU - Nguyen, Dao Thi Anh AU - Nguyen DTA AD - Dai Phuoc Polyclinic, Ho Chi Minh City, Viet Nam. FAU - Phan, Thu Dang Anh AU - Phan TDA AD - Department of Histology-Embryology and Pathology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam. FAU - Ngo, Dat Quoc AU - Ngo DQ AD - Department of Histology-Embryology and Pathology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam. FAU - Hiyama, Toru AU - Hiyama T AD - Health Service Center, Hiroshima University, Higashihiroshima, Japan. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260505 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Colorectal Neoplasms/diagnosis/epidemiology MH - Male MH - Female MH - Vietnam/epidemiology MH - Middle Aged MH - Adult MH - Colonoscopy MH - *Early Detection of Cancer/methods MH - Risk Assessment/methods MH - Aged MH - ROC Curve MH - Adolescent MH - Young Adult MH - Mass Screening/methods PMC - PMC13150889 OTO - NOTNLM OT - Early Detection of Cancer OT - Gastrointestinal tumours OT - Risk Assessment COIS- Competing interests: None declared. EDAT- 2026/05/06 00:35 MHDA- 2026/05/06 00:36 PMCR- 2026/05/05 CRDT- 2026/05/05 20:42 PHST- 2026/05/06 00:36 [medline] PHST- 2026/05/06 00:35 [pubmed] PHST- 2026/05/05 20:42 [entrez] PHST- 2026/05/05 00:00 [pmc-release] AID - bmjopen-2025-102941 [pii] AID - 10.1136/bmjopen-2025-102941 [doi] PST - epublish SO - BMJ Open. 2026 May 5;16(5):e102941. doi: 10.1136/bmjopen-2025-102941. PMID- 42084206 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1545-5017 (Electronic) IS - 1545-5009 (Linking) VI - 73 IP - 7 DP - 2026 Jul TI - Feasibility and Preliminary Efficacy of Integrative Neuromuscular Training for Childhood Cancer Survivors: A Pilot Study. PG - e70377 LID - 10.1002/1545-5017.70377 [doi] AB - BACKGROUND: Survivors of childhood acute lymphoblastic leukemia (ALL) often exhibit early deficits in muscle and movement competence, which can compromise long-term health. Integrative neuromuscular training (INT), a multifaceted approach combining fundamental movement activities with strength exercises, may help address these deficits during critical developmental periods. METHODS: Eight children treated for ALL (aged 6-12 years) completed a supervised INT intervention (2 sessions/week for 8 weeks). Primary outcomes were feasibility (recruitment, retention, adherence, compliance, and tolerance) and program acceptability. Secondary outcomes included muscle function (isometric midthigh pull [IMTP], countermovement jump, and handgrip strength), dual-energy x-ray absorptiometry (DXA)-derived body composition, peripheral quantitative computed tomography (pQCT)-derived muscle measures, and health-related quality of life assessed using the Pediatric Quality of Life Inventory (PedsQL). Pre- to post-intervention changes were evaluated using paired tests (paired t-tests or Wilcoxon signed-rank tests, depending on normality) and corresponding effect sizes (Cohen's d or rank-biserial correlation). RESULTS: Recruitment was 80%, retention was 100%, and adherence was 100%, although the intervention extended beyond 8 weeks. The program was well-tolerated and demonstrated high acceptability, with no adverse events reported. Exploratory analyses suggested improvements in muscle strength (IMTP and countermovement jump peak force, and left handgrip strength), modest increases in whole-body lean mass, and specific PedsQL domains (school functioning, general fatigue, cognitive fatigue), with limited changes in muscle power and pQCT-derived muscle measures. CONCLUSION: INT is feasible and acceptable for survivors of childhood ALL, though maintaining twice-weekly attendance was challenging. Preliminary results indicate potential benefits for muscle strength, mass, and specific quality-of-life domains, underscoring the need for strategies to support consistent participation in this population. CI - (c) 2026 The Author(s). Pediatric Blood & Cancer published by Wiley Periodicals LLC. FAU - Markarian, Anna Maria AU - Markarian AM AUID- ORCID: 0000-0003-2863-1544 AD - Exercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia. AD - School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. FAU - Newton, Robert U AU - Newton RU AUID- ORCID: 0000-0003-0302-6129 AD - Exercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia. AD - School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. FAU - Taaffe, Dennis R AU - Taaffe DR AD - Exercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia. AD - School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. FAU - Gottardo, Nicholas G AU - Gottardo NG AUID- ORCID: 0000-0002-1082-6776 AD - Department of Paediatric and Adolescent Oncology/Haematology, Perth Children's Hospital, Nedlands, Western Australia, Australia. AD - Brain Tumour Research Program, The Kids Institute Australia, Nedlands, Western Australia, Australia. FAU - Valvi, Santosh AU - Valvi S AUID- ORCID: 0000-0002-9655-0001 AD - Department of Paediatric and Adolescent Oncology/Haematology, Perth Children's Hospital, Nedlands, Western Australia, Australia. AD - Brain Tumour Research Program, The Kids Institute Australia, Nedlands, Western Australia, Australia. FAU - Peddle-McIntyre, Carolyn J AU - Peddle-McIntyre CJ AD - Exercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia. AD - School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. FAU - Wilkie, Jodie Cochrane AU - Wilkie JC AUID- ORCID: 0000-0003-1234-9579 AD - Exercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia. AD - School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. AD - Physical Activity, Sport and Exercise Research Theme, Faculty of Health, Southern Cross University, Gold Coast, Australia. FAU - Galvao, Daniel A AU - Galvao DA AD - Exercise Medicine Research Institute, Edith Cowan University, Joondalup, Western Australia, Australia. AD - School of Medical and Health Sciences, Edith Cowan University, Joondalup, Western Australia, Australia. LA - eng PT - Journal Article DEP - 20260505 PL - United States TA - Pediatr Blood Cancer JT - Pediatric blood & cancer JID - 101186624 SB - IM MH - Humans MH - Child MH - Female MH - Pilot Projects MH - Male MH - Feasibility Studies MH - *Precursor Cell Lymphoblastic Leukemia-Lymphoma/rehabilitation/therapy MH - *Quality of Life MH - Muscle Strength MH - *Exercise Therapy/methods MH - Survivors MH - Hand Strength MH - *Cancer Survivors OTO - NOTNLM OT - acute lymphoblastic leukemia OT - feasibility OT - integrative neuromuscular training OT - muscle strength and mass OT - quality of life EDAT- 2026/05/05 12:37 MHDA- 2026/05/26 06:31 CRDT- 2026/05/05 07:53 PHST- 2026/02/07 00:00 [revised] PHST- 2025/12/22 00:00 [received] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/05/26 06:31 [medline] PHST- 2026/05/05 12:37 [pubmed] PHST- 2026/05/05 07:53 [entrez] AID - 10.1002/1545-5017.70377 [doi] PST - ppublish SO - Pediatr Blood Cancer. 2026 Jul;73(7):e70377. doi: 10.1002/1545-5017.70377. Epub 2026 May 5. PMID- 42083482 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260817 IS - 1476-8305 (Electronic) IS - 1028-415X (Linking) VI - 29 IP - 6 DP - 2026 Jun TI - Undernutrition in children with cerebral palsy: comparison of anthropometric measures across gross motor function levels. PG - 679-687 LID - 10.1080/1028415X.2026.2666618 [doi] AB - OBJECTIVE: Nutritional assessment in children with cerebral palsy (CP) remains challenging because growth patterns, body composition, and the feasibility of anthropometric measurements vary according to motor severity. This study aimed to compare anthropometric indicators of undernutrition in children with CP according to Gross Motor Function Classification System (GMFCS) levels. METHODS: In this observational cross-sectional study, forty-three children with CP aged 2-18 years were evaluated. Patients were grouped as GMFCS I-II-III and IV-V. Anthropometric, demographic, and clinical data were analyzed. Undernutrition was defined using age-specific z-scores for height, weight, body mass index (BMI), mid-upper arm circumference (MUAC), and triceps skinfold thickness (TST) based on 'Centers for Disease Control and Prevention' growth charts. Weight-based undernutrition was also re-evaluated using CP-specific Brooks weight-for-age percentiles in a sensitivity analysis. RESULTS: Undernutrition was identified in 33% of patients based on height-for-age z-scores, 49% based on weight-for-age and BMI z-scores, 47% based on MUAC z-scores, and 28% based on TST z-scores. Children in GMFCS IV-V had significantly lower height-for-age, weight-for-age, and MUAC z-scores than those in GMFCS I-II-III (p = 0.02, p < 0.001, p = 0.02, respectively). BMI z-score identified undernutrition more frequently in GMFCS I-II-III, whereas weight-for-age and MUAC z-scores were more informative in GMFCS IV-V. In sensitivity analysis, the higher rate of low weight in the GMFCS IV-V group was less marked with CP-specific Brooks references. DISCUSSION: Undernutrition is frequent in children with CP, particularly in those with more severe motor impairment. Nutritional risk assessment appears to be method- and reference-dependent, supporting a multidimensional anthropometric approach in clinical practice. FAU - Basarir, Gunce AU - Basarir G AUID- ORCID: 0000-0001-5887-6468 AD - Department of Pediatric Neurology, University of Health Sciences, Tepecik Training and Research Hospital, Izmir, Turkiye. AD - Department of Pediatric Neurology, University of Health Sciences, Haseki Training and Research Hospital, Istanbul, Turkiye. FAU - Bozkaya Yilmaz, Sema AU - Bozkaya Yilmaz S AUID- ORCID: 0000-0002-5389-5616 AD - Department of Pediatric Neurology, University of Health Sciences, Tepecik Training and Research Hospital, Izmir, Turkiye. AD - Department of Pediatric Neurology, Bursa City Hospital, Bursa, Turkiye. FAU - Gencpinar, Pinar AU - Gencpinar P AUID- ORCID: 0000-0002-3223-5408 AD - Faculty of Medicine, Department of Pediatric Neurology, Izmir Katip Celebi University, Izmir, Turkiye. AD - Department of Pediatric Neurology, Izmir City Hospital, Izmir, Turkiye. FAU - Olgac Dundar, Nihal AU - Olgac Dundar N AUID- ORCID: 0000-0002-5902-3501 AD - Faculty of Medicine, Department of Pediatric Neurology, Izmir Katip Celebi University, Izmir, Turkiye. AD - Department of Pediatric Neurology, Izmir City Hospital, Izmir, Turkiye. LA - eng PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20260505 PL - England TA - Nutr Neurosci JT - Nutritional neuroscience JID - 100892202 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology/complications MH - Child MH - Child, Preschool MH - Male MH - Female MH - Cross-Sectional Studies MH - Adolescent MH - *Malnutrition/epidemiology/physiopathology/diagnosis/complications MH - Body Mass Index MH - Anthropometry MH - Nutrition Assessment MH - Skinfold Thickness MH - Nutritional Status MH - Body Height MH - Body Weight OTO - NOTNLM OT - Cerebral palsy OT - children OT - gross motor function OT - nutrition assessment OT - undernutrition EDAT- 2026/05/05 06:33 MHDA- 2026/06/01 18:50 CRDT- 2026/05/05 03:13 PHST- 2026/06/01 18:50 [medline] PHST- 2026/05/05 06:33 [pubmed] PHST- 2026/05/05 03:13 [entrez] AID - 10.1080/1028415X.2026.2666618 [doi] PST - ppublish SO - Nutr Neurosci. 2026 Jun;29(6):679-687. doi: 10.1080/1028415X.2026.2666618. Epub 2026 May 5. PMID- 42083463 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1814-1412 (Electronic) IS - 1562-2975 (Linking) VI - 27 IP - 5 DP - 2026 Jun TI - Changes of laboratory parameters during olanzapine treatment in young people with anorexia nervosa: exploratory results from the OPEN study. PG - 502-508 LID - 10.1080/15622975.2026.2665627 [doi] AB - BACKGROUND: While olanzapine is recommended for promoting weight recovery in adults with anorexia nervosa (AN), its use in young people remains under-researched, necessitating the careful monitoring of blood-based laboratory parameters to manage the potential side effects of olanzapine. METHODS: In the OPEN feasibility study which tested olanzapine treatment over 6 months in young people with AN, 15 study participants (aged 12-23) adhered to olanzapine treatment for at least 16 weeks and had clinical blood-based laboratory parameters measured. RESULTS: In an exploratory analysis, we found a mean increase of 0.06 x 10(9)/L in white blood cell count (WBC) (0.01, 0.11 95% CI) per week. Bilirubin decreased by 0.11 mg/dL (-0.19, -0.04 95% CI) per week, and serum albumin levels dropped slightly by 0.20 g/L (-0.29, -0.11 95% CI) per week. Electrolytes, liver enzymes, total cholesterol and triglycerides remained stable during treatment with olanzapine. CONCLUSIONS: Whereas the increase in WBC and the decrease in bilirubin likely reflect nutritional rehabilitation, the reason for the albumin reduction is unclear. Thus, monitoring serum albumin during trials and clinical treatment for AN with olanzapine is advised. FAU - Xu, Can AU - Xu C AD - Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, Centre for Research in Eating and Weight Disorders (CREW), London, UK. FAU - Morris, Rebecca AU - Morris R AD - Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, Centre for Research in Eating and Weight Disorders (CREW), London, UK. FAU - Stringer, Dominic AU - Stringer D AD - Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. AD - King's Clinical Trials Unit, King's College London, London, UK. FAU - Said, Olena AU - Said O AD - Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, Centre for Research in Eating and Weight Disorders (CREW), London, UK. AD - King's Clinical Trials Unit, King's College London, London, UK. FAU - Sengun Filiz, Ece AU - Sengun Filiz E AD - Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK. FAU - Carter, Ben AU - Carter B AD - Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. AD - King's Clinical Trials Unit, King's College London, London, UK. FAU - Bentley, Jessica AU - Bentley J AD - Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, Centre for Research in Eating and Weight Disorders (CREW), London, UK. FAU - Treasure, Janet AU - Treasure J AD - Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, Centre for Research in Eating and Weight Disorders (CREW), London, UK. AD - South London and Maudsley NHS Foundation Trust, London, UK. FAU - Schmidt, Ulrike AU - Schmidt U AD - Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, Centre for Research in Eating and Weight Disorders (CREW), London, UK. AD - South London and Maudsley NHS Foundation Trust, London, UK. FAU - Nicholls, Dasha AU - Nicholls D AD - Division of Psychiatry, Department of Brain Sciences, Imperial College London, London, UK. FAU - Himmerich, Hubertus AU - Himmerich H AUID- ORCID: 0000-0003-1209-6073 AD - Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, Centre for Research in Eating and Weight Disorders (CREW), London, UK. AD - South London and Maudsley NHS Foundation Trust, London, UK. LA - eng PT - Journal Article DEP - 20260504 PL - England TA - World J Biol Psychiatry JT - The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry JID - 101120023 RN - N7U69T4SZR (Olanzapine) RN - 12794-10-4 (Benzodiazepines) RN - 0 (Antipsychotic Agents) RN - 0 (Serum Albumin) RN - RFM9X3LJ49 (Bilirubin) SB - IM MH - Humans MH - Olanzapine MH - *Anorexia Nervosa/drug therapy/blood MH - Female MH - Adolescent MH - Young Adult MH - Child MH - *Benzodiazepines/adverse effects/therapeutic use MH - *Antipsychotic Agents/adverse effects/therapeutic use MH - *Serum Albumin/drug effects MH - Leukocyte Count MH - *Bilirubin/blood MH - Feasibility Studies MH - Male OTO - NOTNLM OT - Anorexia nervosa OT - laboratory parameters OT - olanzapine OT - side effects EDAT- 2026/05/05 06:33 MHDA- 2026/05/28 00:30 CRDT- 2026/05/05 02:53 PHST- 2026/05/28 00:30 [medline] PHST- 2026/05/05 06:33 [pubmed] PHST- 2026/05/05 02:53 [entrez] AID - 10.1080/15622975.2026.2665627 [doi] PST - ppublish SO - World J Biol Psychiatry. 2026 Jun;27(5):502-508. doi: 10.1080/15622975.2026.2665627. Epub 2026 May 4. PMID- 42081847 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1873-5347 (Electronic) IS - 0277-9536 (Linking) VI - 401 DP - 2026 Jul TI - Children's voices in community-based promotion of childhood health and wellbeing and the responses of community stakeholders. PG - 119225 LID - S0277-9536(26)00301-1 [pii] LID - 10.1016/j.socscimed.2026.119225 [doi] AB - Rising childhood obesity highlights the need for preventive strategies. Community-based approaches and the inclusion of children's perspectives have been recommended; however, children's involvement often remains symbolic, with little translation of their views into action. Aiming to guide involvement, this study explores the process of conveying 7-10-year-old children's perspectives on leisure time and local health initiatives to adult community stakeholders and to examine stakeholders' engagement with children's perspectives. The study is part of the Danish project Generation Healthy Kids. We conducted 15 workshops with 57 children to explore their perspectives on leisure and health initiatives within their community. Using a modified Write, Draw, Show and Tell approach, we collected and thematically analyzed audio recordings, post-it notes, and drawings from workshops. Findings were presented to adult stakeholders in six communities and their responses documented. Children identified organized sports, activities with family and friends, and varied creative after-school activities as important for good leisure time, while negative influences included chores, conflicts, loneliness, injuries, and failures. They valued community initiatives including family, storytelling, exploration, and a festive atmosphere. Stakeholders responded to the perspectives with interest and requests for actionable, local insights. Further, there was a tendency among some stakeholders to maintain an adult perspective and focus on feasibility concerns when discussing the use of children's perspectives in developing or refining local health initiatives. Our findings suggest that to support the process of translating children's perspectives into action, consideration of participation levels, timing, and ethics is essential. Multimodal methods can be used to accommodate children's diverse ways of expression and involving children earlier and more actively is recommended. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Vilhelmsen, Maja AU - Vilhelmsen M AD - Department of Prevention, Health Promotion and Community Care, Steno Diabetes Center Copenhagen, Borgmester Ib Juels Vej, Herlev, 2730, Denmark; Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Nordre Fasanvej 57, Frederiksberg, 2000, Denmark. Electronic address: maja.vilhelmsen@regionh.dk. FAU - Amled, Thomas AU - Amled T AD - Department of Prevention, Health Promotion and Community Care, Steno Diabetes Center Copenhagen, Borgmester Ib Juels Vej, Herlev, 2730, Denmark. FAU - Hoeeg, Didde AU - Hoeeg D AD - Department of Prevention, Health Promotion and Community Care, Steno Diabetes Center Copenhagen, Borgmester Ib Juels Vej, Herlev, 2730, Denmark. FAU - Bloch, Paul AU - Bloch P AD - Department of Prevention, Health Promotion and Community Care, Steno Diabetes Center Copenhagen, Borgmester Ib Juels Vej, Herlev, 2730, Denmark. FAU - Bratsch, Louise A S AU - Bratsch LAS AD - National Institute of Public Health, Southern University of Denmark, Studiestraede 6, Copenhagen K, 1455, Denmark. FAU - Ma, Jiani AU - Ma J AD - Institute for Physical Activity and Nutrition, Deakin University, School of Exercise and Nutrition Sciences, Faculty of Health, 221 Burwood Highway, Burwood, VIC, 3125, Australia. FAU - Toft, Ulla AU - Toft U AD - Department of Prevention, Health Promotion and Community Care, Steno Diabetes Center Copenhagen, Borgmester Ib Juels Vej, Herlev, 2730, Denmark; Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, Copenhagen N, 2200, Denmark. LA - eng PT - Journal Article DEP - 20260328 PL - England TA - Soc Sci Med JT - Social science & medicine (1982) JID - 8303205 SB - IM MH - Humans MH - Child MH - *Health Promotion/methods MH - Female MH - Denmark MH - Male MH - *Child Health MH - Leisure Activities/psychology MH - Qualitative Research MH - *Community Participation COIS- Declaration of interest The authors have declared that no competing interests exist. EDAT- 2026/05/04 18:34 MHDA- 2026/05/15 00:31 CRDT- 2026/05/04 17:59 PHST- 2025/10/14 00:00 [received] PHST- 2026/03/10 00:00 [revised] PHST- 2026/03/21 00:00 [accepted] PHST- 2026/05/15 00:31 [medline] PHST- 2026/05/04 18:34 [pubmed] PHST- 2026/05/04 17:59 [entrez] AID - S0277-9536(26)00301-1 [pii] AID - 10.1016/j.socscimed.2026.119225 [doi] PST - ppublish SO - Soc Sci Med. 2026 Jul;401:119225. doi: 10.1016/j.socscimed.2026.119225. Epub 2026 Mar 28. PMID- 42081800 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260905 IS - 2292-9495 (Electronic) IS - 2292-9495 (Linking) VI - 13 DP - 2026 May 4 TI - High Screen Exposure and Its Association With Physical and Mental Well-Being Among School-Going Children and Adolescents in Bangladesh: Cross-Sectional Study. PG - e73524 LID - 10.2196/73524 [doi] LID - e73524 AB - BACKGROUND: In Bangladesh, as well as throughout the world, children's screen time has significantly increased. Children spend a lot of time on the internet and digital screens for entertainment, education, and communication, which has increased their daily screen time. However, the potential detrimental impacts of excessive screen time on children's mental, physical, and social health have drawn attention. OBJECTIVE: This study aimed to explore the effect of high exposure to screens on the health and mental well-being of school-going children and adolescents in Dhaka, Bangladesh. METHODS: This cross-sectional descriptive study was conducted from July 2022 to June 2024. A total of 420 school-going children and adolescents aged 6 to 14 years were enrolled from 3 English-language and 3 Bangla-language schools in Dhaka using a stratified random sampling technique. Anthropometric measurements, a semistructured questionnaire, and the Pittsburgh Sleep Quality Index, the Development and Well-Being Assessment scale, and the Strengths and Difficulties Questionnaire, all of which were validated in Bangla, were used to gather data. We considered students who were exposed to screens for less than 2 hours a day as the low-exposure group and those who were exposed for more than 2 hours a day as the high-exposure group. RESULTS: A total of 83.3% (350/420) of the students were in the high-exposure group, and their average screen time per day was 4.6 (SD 2.3) hours. Eye problems were reported by 35.7% (150/420) of the students, and a significant difference was found between the low- and high-exposure groups. In total, 96% (144/150) of the students with eye problems were from the high-exposure group, whereas 4% (6/150) were from the low-exposure group. Headaches were reported by 80% (336/420) of the students, and they were common in the high-exposure group (279/336, 83%). Moreover, students from the high-exposure group had a short duration and poor quality of sleep (mean 7.3, SD 1.4 hours), which was statistically significant. Furthermore, obesity was more predominant in the high-exposure group (P<.001). Our study revealed that, overall, 31% (130/420) of the students had at least one mental health problem and 9.8% (41/420) had more than one mental health problem using the Development and Well-Being Assessment scale, and mental health problems were greater in the high-exposure group than the low-exposure group. Although behavioral problems such as conduct issues (119/420, 28.3%) and peer difficulties (121/420, 28.8%) were observed among the participants, no statistically significant difference was found between the 2 groups. CONCLUSIONS: A collaborative and coordinated multistage approach is essential to create effective and acceptable guidelines and policies for the optimum and positive use of digital screens for the children of Bangladesh. Further prospective studies on a larger scale can be conducted to determine the impacts of screen time on aspects of health. CI - (c) Shahria Hafiz Kakon, Tanjir Rashid Soron, Mohammad Sharif Hossain, Biplob Hossain, Fahmida Tofail, Rashidul Haque. Originally published in JMIR Human Factors (https://humanfactors.jmir.org). FAU - Kakon, Shahria Hafiz AU - Kakon SH AUID- ORCID: 0000-0002-1127-4993 AD - icddr,b, 68, Shaheed Tajuddin Ahmed Sarani. Mohakhali, Dhaka, 1212, Bangladesh, 880 1726428760. FAU - Soron, Tanjir Rashid AU - Soron TR AUID- ORCID: 0000-0001-9810-5000 AD - Tele psychiatry Research and Innovation Network Ltd, Dhaka, Bangladesh. FAU - Hossain, Mohammad Sharif AU - Hossain MS AUID- ORCID: 0000-0002-9876-7722 AD - icddr,b, 68, Shaheed Tajuddin Ahmed Sarani. Mohakhali, Dhaka, 1212, Bangladesh, 880 1726428760. FAU - Hossain, Biplob AU - Hossain B AUID- ORCID: 0000-0002-4934-9866 AD - icddr,b, 68, Shaheed Tajuddin Ahmed Sarani. Mohakhali, Dhaka, 1212, Bangladesh, 880 1726428760. FAU - Tofail, Fahmida AU - Tofail F AUID- ORCID: 0000-0003-2301-9196 AD - icddr,b, 68, Shaheed Tajuddin Ahmed Sarani. Mohakhali, Dhaka, 1212, Bangladesh, 880 1726428760. FAU - Haque, Rashidul AU - Haque R AUID- ORCID: 0000-0001-5100-136X AD - icddr,b, 68, Shaheed Tajuddin Ahmed Sarani. Mohakhali, Dhaka, 1212, Bangladesh, 880 1726428760. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260504 PL - Canada TA - JMIR Hum Factors JT - JMIR human factors JID - 101666561 SB - IM MH - Humans MH - Bangladesh/epidemiology MH - Cross-Sectional Studies MH - Child MH - *Screen Time MH - Adolescent MH - Female MH - Male MH - *Mental Health/statistics & numerical data MH - *Students/statistics & numerical data/psychology MH - Psychological Well-Being MH - Media Exposure MH - Schools MH - Surveys and Questionnaires MH - Digital Media PMC - PMC13138789 OTO - NOTNLM OT - Bangladesh OT - Development and Well-Being Assessment scale OT - Pittsburgh Sleep Quality Index OT - Strengths and Difficulties Questionnaire OT - high exposure OT - screen time COIS- Conflicts of Interest: None declared. EDAT- 2026/05/04 18:33 MHDA- 2026/05/04 18:34 PMCR- 2026/05/04 CRDT- 2026/05/04 16:53 PHST- 2025/03/06 00:00 [received] PHST- 2026/02/13 00:00 [revised] PHST- 2026/02/19 00:00 [accepted] PHST- 2026/05/04 18:34 [medline] PHST- 2026/05/04 18:33 [pubmed] PHST- 2026/05/04 16:53 [entrez] PHST- 2026/05/04 00:00 [pmc-release] AID - v13i1e73524 [pii] AID - 73524 [pii] AID - 10.2196/73524 [doi] PST - epublish SO - JMIR Hum Factors. 2026 May 4;13:e73524. doi: 10.2196/73524. PMID- 42081744 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260910 IS - 2291-5222 (Electronic) IS - 2291-5222 (Linking) VI - 14 DP - 2026 May 4 TI - Traditional Social Sports Games and Mental Training for Smartphone Addiction and Psychological Distress in School-Aged Adolescents: Randomized Controlled Trial. PG - e85353 LID - 10.2196/85353 [doi] LID - e85353 AB - BACKGROUND: Problematic smartphone use among adolescents is a growing public health concern closely associated with psychological distress and loneliness. Effective, culturally grounded, school-based interventions are needed. OBJECTIVE: The aim of this study was to assess the effects of a 12-week program combining traditional social sports games and mental exercises on smartphone addiction, nomophobia, psychological distress, and loneliness in adolescents. METHODS: In this randomized controlled trial, 69 school-recruited Tunisian adolescents (aged 14-16 years) with clinically elevated smartphone addiction scores were assigned to an experimental group (n=36, 52.2%) or a control group (n=33, 47.8%). The experimental group received a 12-week intervention comprising 4 weekly sessions integrating traditional social sports games with mental exercises, whereas the control group continued standard physical education. Outcomes (smartphone addiction, nomophobia, psychological distress, and loneliness) were assessed at baseline and after the intervention using scales validated in Arabic. RESULTS: Linear mixed-effects models adjusted for age, sex, and BMI revealed significant group x time interactions of moderate magnitude across all outcomes (P<.05 in all cases) favoring the experimental group. Adjusted postintervention comparisons confirmed significantly lower scores in the experimental group for smartphone addiction, nomophobia, psychological distress, and loneliness (P<.05 in all cases; partial etap2=0.08-0.12). Mediation analysis indicated that reductions in loneliness accounted for 34.4% of the intervention's effect on smartphone addiction, consistent with partial mediation. CONCLUSIONS: A culturally adapted, school-based intervention combining traditional social sports games and mental exercises significantly reduced problematic smartphone use and improved psychological well-being. The partial mediation through reduced loneliness highlights the critical role of social connectedness in adolescent digital health interventions. CI - (c) Mohamed Yaakoubi, Ahmed Ghorbel, Hiba Abdelkafi, Liwa Masmoudi, Omar Trabelsi, Safaa M. Elkholi, Fatma H. Yagin, Georgian Badicu, Adnene Gharbi. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org). FAU - Yaakoubi, Mohamed AU - Yaakoubi M AUID- ORCID: 0009-0003-5187-236X AD - High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. FAU - Ghorbel, Ahmed AU - Ghorbel A AUID- ORCID: 0009-0004-6890-9867 AD - High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. FAU - Abdelkafi, Hiba AU - Abdelkafi H AUID- ORCID: 0000-0002-9869-456X AD - The High Institute of Applied Studies in Humanities of Mahdia, Department of Education Sciences, University of Monastir, Mahdia, Tunis, Tunisia. FAU - Masmoudi, Liwa AU - Masmoudi L AUID- ORCID: 0000-0002-9628-1585 AD - High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. FAU - Trabelsi, Omar AU - Trabelsi O AUID- ORCID: 0009-0008-2568-3000 AD - High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. AD - The High Institute of Applied Studies in Humanities of Mahdia, Department of Education Sciences, University of Monastir, Mahdia, Tunis, Tunisia. FAU - Elkholi, Safaa M AU - Elkholi SM AUID- ORCID: 0000-0002-1100-4301 AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Riyadh, 84428, Saudi Arabia. FAU - Yagin, Fatma H AU - Yagin FH AUID- ORCID: 0000-0002-9848-7958 AD - Department of Biostatistics, Faculty of Medicine, Malatya Turgut Ozal University, 44210, Malatya, Turkey. FAU - Badicu, Georgian AU - Badicu G AUID- ORCID: 0000-0003-4100-8765 AD - Department of Physical Education and Special Motricity, University Transilvania of Brasov, Brasov, Romania. FAU - Gharbi, Adnene AU - Gharbi A AUID- ORCID: 0000-0001-9971-1993 AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. AD - High Institute of Sports and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. LA - eng SI - PACTR/PACTR202601838702413 PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20260504 PL - Canada TA - JMIR Mhealth Uhealth JT - JMIR mHealth and uHealth JID - 101624439 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - *Psychological Distress MH - *Internet Addiction Disorder/psychology/therapy MH - Tunisia MH - Surveys and Questionnaires MH - Smartphone/statistics & numerical data MH - *Video Games/psychology/standards MH - Loneliness/psychology MH - Psychometrics/methods/instrumentation MH - Behavior, Addictive/psychology/therapy PMC - PMC13138712 OTO - NOTNLM OT - Tunisia OT - adolescents OT - loneliness OT - psychological distress OT - randomized controlled trial OT - smartphone addiction COIS- Conflicts of Interest: None declared. EDAT- 2026/05/04 18:33 MHDA- 2026/05/04 18:34 PMCR- 2026/05/04 CRDT- 2026/05/04 15:43 PHST- 2025/10/06 00:00 [received] PHST- 2026/04/02 00:00 [revised] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/05/04 18:34 [medline] PHST- 2026/05/04 18:33 [pubmed] PHST- 2026/05/04 15:43 [entrez] PHST- 2026/05/04 00:00 [pmc-release] AID - v14i1e85353 [pii] AID - 85353 [pii] AID - 10.2196/85353 [doi] PST - epublish SO - JMIR Mhealth Uhealth. 2026 May 4;14:e85353. doi: 10.2196/85353. PMID- 42081240 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260923 IS - 2168-6211 (Electronic) IS - 2168-6203 (Print) IS - 2168-6203 (Linking) VI - 180 IP - 8 DP - 2026 Aug 1 TI - Risk and Protective Factors Associated With HIV-Related Mortality in Children Receiving Antiretroviral Therapy: A Model-Based Meta-Regression. PG - 829-837 LID - 10.1001/jamapediatrics.2026.1235 [doi] AB - IMPORTANCE: Mortality among children and young adolescents receiving antiretroviral therapy (ART) remains substantially higher in resource-limited settings compared with resource-rich regions. The role of modifiable risk and protective factors in explaining this global variation remains poorly understood. OBJECTIVE: To identify and quantify country-level modifiable risk and protective factors associated with HIV-related mortality among children and young adolescents receiving ART. DESIGN, SETTING, AND PARTICIPANTS: This model-based meta-regression analysis linked HIV-related mortality data from cohort studies included in a published systematic review of children and adolescents (aged 0-14 years) receiving ART, with biomedical, behavioral, and structural factors from the Global Burden of Diseases, Injuries, and Risk Factors study 2023. Data were analyzed using penalized regression (ridge regression with cross-validation) and an ensemble machine-learning algorithm (XGBoost). Study data were analyzed from August 2024 to October 2025. EXPOSURES: Country-level modifiable covariates, including access to improved water, vaccine coverage against different pathogens, maternal education, underweight proportion, and oral rehydration coverage. MAIN OUTCOMES AND MEASURES: Measures included the odds ratios (ORs) of HIV-related mortality while receiving ART associated with modifiable factors, simulations of hypothetical 10% and 20% increases in covariates, and variable importance via Shapley Additive Explanation (SHAP) values. RESULTS: HIV-related mortality data from 67 cohort studies were included in this analysis. Access to improved water, pneumococcal conjugate vaccine third-dose (PCV3) coverage, and maternal education demonstrated the strongest independent associations with HIV-related mortality while receiving ART. A 10% increase in improved water access, PCV3 coverage, and maternal education was associated with lower odds of mortality (OR, 0.83; 95% CI, 0.826-0.843; OR, 0.980; 95% CI, 0.972-0.987; and OR, 0.997; 95% CI, 0.996-0.998, respectively). At 20% increases, these protective associations with HIV-related mortality were stronger (OR, 0.695; 95% CI, 0.682-0.711; OR, 0.959; 95% CI, 0.945-0.974; and OR, 0.994; 95% CI, 0.992-0.997, respectively). SHAP-based analyses consistently ranked these 3 factors as most predictive of HIV-related mortality. CONCLUSIONS AND RELEVANCE: Findings of this model-based meta-regression analysis show that improved water access, PCV3 coverage, and maternal education were associated with lower HIV-related mortality among children receiving ART, underscoring the need for integrated public health strategies beyond ART alone. Interventions to strengthen water infrastructure, vaccination programs, and maternal education may help reduce global survival disparities among children and adolescents living with HIV and receiving ART. FAU - He, Jiawei AU - He J AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. AD - Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle. FAU - Kassanjee, Reshma AU - Kassanjee R AD - Centre for Integrated Data and Epidemiological Research, School of Public Health, University of Cape Town, Cape Town, South Africa. FAU - Movo, Amanda AU - Movo A AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. FAU - Walters, Magdalene K AU - Walters MK AD - MRC Centre for Global Infectious Disease Analysis, School of Public Health, Imperial College London, London, United Kingdom. FAU - Brewer, Edmond AU - Brewer E AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. FAU - Sorensen, Reed J D AU - Sorensen RJD AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. FAU - Hay, Simon I AU - Hay SI AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. AD - Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle. FAU - Murray, Christopher J L AU - Murray CJL AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. AD - Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle. FAU - Flaxman, Abraham AU - Flaxman A AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. AD - Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle. FAU - Aravkin, Aleksandr AU - Aravkin A AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. AD - Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle. FAU - Zheng, Peng AU - Zheng P AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. AD - Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle. FAU - Kyu, Hmwe H AU - Kyu HH AD - Institute for Health Metrics and Evaluation, University of Washington, Seattle. AD - Department of Health Metrics Sciences, School of Medicine, University of Washington, Seattle. LA - eng GR - U01 AI096299/AI/NIAID NIH HHS/United States GR - U01 AI069923/AI/NIAID NIH HHS/United States GR - R01 AI152721/AI/NIAID NIH HHS/United States GR - U01 AI069911/AI/NIAID NIH HHS/United States GR - U01 AI069919/AI/NIAID NIH HHS/United States GR - U01 AI069907/AI/NIAID NIH HHS/United States GR - U01 AI069924/AI/NIAID NIH HHS/United States PT - Journal Article PT - Meta-Analysis PT - Systematic Review PL - United States TA - JAMA Pediatr JT - JAMA pediatrics JID - 101589544 RN - 0 (Anti-Retroviral Agents) RN - 0 (Anti-HIV Agents) SB - IM CIN - JAMA Pediatr. 2026 Aug 1;180(8):821-822. doi: 10.1001/jamapediatrics.2026.1277. PMID: 42081239 MH - Humans MH - *HIV Infections/mortality/drug therapy MH - Adolescent MH - Child MH - Risk Factors MH - Child, Preschool MH - Protective Factors MH - Infant MH - Female MH - Male MH - *Anti-Retroviral Agents/therapeutic use MH - *Anti-HIV Agents/therapeutic use MH - Infant, Newborn MH - Resource-Limited Settings PMC - PMC13140089 MID - NIHMS2170032 COIS- Conflict of Interest Disclosures: Dr Kassanjee reported receiving salary support from the University of Cape Town through National Institutes of Health (NIH) grants during the conduct of the study. Ms Movo reported receiving salary support from grants provided by Gates Foundation outside the submitted work. Dr Kyu reported receiving grant support from the NIH during the conduct of the study and being employed at the Institute for Health Metrics and Evaluation, which is funded by the Gates Foundation, outside the submitted work. No other disclosures were reported. EDAT- 2026/05/04 12:34 MHDA- 2026/08/03 12:42 PMCR- 2026/07/02 CRDT- 2026/05/04 11:33 PHST- 2026/08/03 12:42 [medline] PHST- 2026/05/04 12:34 [pubmed] PHST- 2026/05/04 11:33 [entrez] PHST- 2026/07/02 00:00 [pmc-release] AID - 2848569 [pii] AID - 10.1001/jamapediatrics.2026.1235 [doi] PST - ppublish SO - JAMA Pediatr. 2026 Aug 1;180(8):829-837. doi: 10.1001/jamapediatrics.2026.1235. PMID- 42080686 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1998-3905 (Electronic) IS - 0970-4388 (Linking) VI - 44 IP - 2 DP - 2026 Mar 1 TI - Feeding at sleep time and early childhood caries: Validation of the feeding at sleep time (FeAST) scale in 12-36-month-old children in Bhubaneswar, Odisha. PG - 157-163 LID - 10.4103/jisppd.jisppd_1_26 [doi] AB - CONTEXT: Early childhood caries (ECC) remains a major public health concern in India, with feeding-at-sleep behaviors recognized as important behavioral risk factors. The feeding at sleep time (FeAST) scale was developed to quantify such behaviors, but its applicability across diverse Indian sociocultural settings remains uncertain. AIMS: To evaluate the external validity of the FeAST scale in identifying ECC risk among 12-36-month-old toddlers in Bhubaneswar, Odisha, and to examine the association between socioeconomic status and ECC. SETTINGS AND DESIGN: A hospital-based cross-sectional study conducted in a tertiary care teaching hospital in Bhubaneswar, Eastern India. MATERIALS AND METHODS: A total of 387 toddlers aged 12-36 months and their caregivers were recruited. Feeding behaviors were assessed using the original FeAST questionnaire, generating scores for combined breastfeeding (CBR), combined bottle-feeding (CBO), and other feeding constructs (OFC). ECC status was determined through oral examination. SES was classified using the updated B. G. Prasad Scale (2025). STATISTICAL ANALYSIS: Receiver operating characteristic analysis with a minimal cutoff score was used to determine diagnostic accuracy. Chi-square test assessed associations between ECC and SES. Statistical significance was set at P < 0.05. RESULTS: ECC prevalence was 32.9%. CBR (AUC = 0.446) and CBO (AUC = 0.481) demonstrated poor discriminatory ability, while OFC showed modest performance (AUC = 0.577). No significant association was found between ECC and SES ( P = 0.511). CONCLUSIONS: The FeAST scale demonstrated limited diagnostic validity in this Eastern Indian cohort, indicating the need for regional recalibration incorporating contextual feeding and oral hygiene behaviors. CI - Copyright (c) 2026 Journal of Indian Society of Pedodontics and Preventive Dentistry. FAU - Taraphder, Rupsa AU - Taraphder R AD - Department of Pediatric and Preventive Dentistry, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology Deemed to be University, Bhubaneswar, Odisha, India. FAU - Dutta, Brahmananda AU - Dutta B AD - Department of Pediatric and Preventive Dentistry, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology Deemed to be University, Bhubaneswar, Odisha, India. FAU - Dhull, Kanika Singh AU - Dhull KS AD - Department of Pediatric and Preventive Dentistry, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology Deemed to be University, Bhubaneswar, Odisha, India. FAU - Abbasi, Aiman Itrat AU - Abbasi AI AD - Bristol Medical School, University of Bristol, Bristol, UK. FAU - Roy, Bhaswati AU - Roy B AD - Department of Pediatric and Preventive Dentistry, Kalinga Institute of Dental Sciences, Kalinga Institute of Industrial Technology Deemed to be University, Bhubaneswar, Odisha, India. LA - eng PT - Journal Article PT - Validation Study DEP - 20260430 PL - India TA - J Indian Soc Pedod Prev Dent JT - Journal of the Indian Society of Pedodontics and Preventive Dentistry JID - 8710631 SB - IM MH - Humans MH - India/epidemiology MH - Infant MH - *Dental Caries/epidemiology MH - Cross-Sectional Studies MH - Male MH - Female MH - *Feeding Behavior MH - Child, Preschool MH - *Sleep MH - Bottle Feeding MH - Breast Feeding MH - Surveys and Questionnaires MH - Risk Factors OTO - NOTNLM OT - Early childhood caries OT - feeding at sleep time OT - feeding at sleep time scale OT - infant feeding practices OT - socioeconomic status EDAT- 2026/05/04 12:34 MHDA- 2026/05/04 12:35 CRDT- 2026/05/04 10:11 PHST- 2026/01/01 00:00 [received] PHST- 2026/02/23 00:00 [accepted] PHST- 2026/05/04 12:35 [medline] PHST- 2026/05/04 12:34 [pubmed] PHST- 2026/05/04 10:11 [entrez] AID - 00005097-202603000-00005 [pii] AID - 10.4103/jisppd.jisppd_1_26 [doi] PST - ppublish SO - J Indian Soc Pedod Prev Dent. 2026 Mar 1;44(2):157-163. doi: 10.4103/jisppd.jisppd_1_26. Epub 2026 Apr 30. PMID- 42080468 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1442-2042 (Electronic) IS - 0919-8172 (Linking) VI - 33 IP - 5 DP - 2026 May TI - A Novel Prediction Model for Monorchidism in Boys With Unilateral Nonpalpable Testes: Diagnostic Utility of Preoperative Ultrasonography. PG - e70482 LID - 10.1111/iju.70482 [doi] AB - INTRODUCTION: In boys with non-palpable testis (NPT), the affected side may present as a viable testis (VT) or a nonviable testis (NVT), the latter representing true monorchidism. This study evaluated the utility of ultrasonography (US) for predicting monorchidism and testicular location in unilateral NPT. METHODS: We retrospectively reviewed boys with unilateral NPT who underwent preoperative US between 2009 and 2025. Testicular volumes were converted to age-adjusted standard deviation (SD) scores. A rule-based model classified NVT when the affected testis was visualized with an SD score /= cutoff B. If the affected testis was not visualized, an SD score >/= cutoff C for the unaffected testis indicated NVT; remaining cases were classified as VT. Predictions were compared with intraoperative findings. Receiver operating characteristic analysis determined optimal cutoffs. Internal validation using repeated stratified five-fold cross-validation and bootstrap resampling assessed model performance and threshold stability. US-based localization was also compared with surgical findings. RESULTS: Sixty-nine boys were included; surgery identified 51 NVT and 18 VT. Optimal cutoffs were A = -2.60, B = +0.45, and C = +0.60. The model achieved an AUC of 96.1%, with 100% sensitivity, 92.2% specificity, 81.8% positive predictive value, and 100% negative predictive value. Internal validation showed median AUCs of 90.0% and 89.4%, with stable thresholds. Localization accuracy was 66.6%. CONCLUSION: A rulebased US model may predict monorchidism in unilateral NPT with a very low risk of misclassifying VT as NVT, despite its limited ability to determine testicular location. CI - (c) 2026 The Japanese Urological Association. FAU - Muranishi, Yuki AU - Muranishi Y AUID- ORCID: 0009-0001-7989-6748 AD - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. FAU - Osawa, Takahiro AU - Osawa T AUID- ORCID: 0000-0003-4444-7958 AD - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. FAU - Hirata, Yurie AU - Hirata Y AUID- ORCID: 0000-0002-3930-0233 AD - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. FAU - Higuchi, Madoka AU - Higuchi M AD - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. FAU - Chiba, Hiroki AU - Chiba H AUID- ORCID: 0000-0001-7042-8211 AD - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. FAU - Horie, Tatsunori AU - Horie T AD - Diagnostic Center for Sonography, Hokkaido University Hospital, Sapporo, Japan. FAU - Sakamoto, Keita AU - Sakamoto K AD - Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan. FAU - Ito, Yoichi M AU - Ito YM AD - Data Science Center, Promotion Unit, Institution of Health Science Innovation for Medical Care, Hokkaido University Hospital, Sapporo, Japan. FAU - Kon, Masafumi AU - Kon M AD - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. FAU - Abe, Takashige AU - Abe T AD - Department of Renal and Genitourinary Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan. LA - eng PT - Journal Article PL - Australia TA - Int J Urol JT - International journal of urology : official journal of the Japanese Urological Association JID - 9440237 SB - IM MH - Humans MH - Male MH - Retrospective Studies MH - Ultrasonography MH - *Testis/diagnostic imaging/abnormalities/surgery MH - Infant MH - Child, Preschool MH - *Cryptorchidism/diagnostic imaging/surgery/diagnosis MH - Predictive Value of Tests MH - Preoperative Care/methods MH - ROC Curve MH - Organ Size OTO - NOTNLM OT - monorchidism OT - non-palpable testis OT - testicular location OT - testicular volume OT - ultrasonography EDAT- 2026/05/04 12:33 MHDA- 2026/05/04 12:34 CRDT- 2026/05/04 08:23 PHST- 2026/03/03 00:00 [revised] PHST- 2025/12/14 00:00 [received] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/05/04 12:34 [medline] PHST- 2026/05/04 12:33 [pubmed] PHST- 2026/05/04 08:23 [entrez] AID - 10.1111/iju.70482 [doi] PST - ppublish SO - Int J Urol. 2026 May;33(5):e70482. doi: 10.1111/iju.70482. PMID- 42080151 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260504 LR - 20260813 IS - 2772-3682 (Electronic) IS - 2772-3682 (Linking) VI - 48 DP - 2026 May TI - Accuracy of a smartphone-based 3D imaging tool for height measurement and stunting detection among children 24-59 months of age in Nepal: a validation study. PG - 100774 LID - 10.1016/j.lansea.2026.100774 [doi] LID - 100774 AB - BACKGROUND: Detection of stunting in young children using traditional anthropometry has been a challenge at the community level especially in resource-constrained settings. We evaluated the performance of Child Growth Monitor (CGM), a smartphone-based 3D depth-imaging application, for screening of stunting, and height measurement among children (24-59 months of age) in Nepal. METHODS: At four health-posts in Rautahat district, Nepal, in October 2024, we conducted cross-sectional validation study comparing CGM's stunting detection against gold standard (manual measurement) and prospective reliability assessment with repeat measurements, four days apart. Eight trained enumerators collected data using calibrated height boards and CGM app. Validity was assessed through sensitivity, specificity and accuracy, reliability through intraclass correlation coefficients (ICC) and Technical Error of Measurement (TEM). Pitman's test evaluated variance. Bias was assessed using Bland Altman statistics. FINDINGS: 310 children were recruited, with analyses based on paired subsets (n = 261). Manual measurements identified 36% as stunted, while CGM detected 31.8%. CGM demonstrated 84.0% sensitivity, 98.2% specificity, 96.3% positive and 91.6% negative predictive values, and 93.1% accuracy. For height measurement, the ICC for intra-rater and inter-rater reliability were 0.990 (n = 76) and 0.992 (n = 75) respectively, with intra- and inter-rater TEM of 0.5 cm. Inter-method TEM was 0.7 cm. Pitman's test was significant; Bland-Altman showed mean bias of 0.3 cm. INTERPRETATION: CGM demonstrated accuracy and reliability for field-based stunting detection among children belonging to 24-59 months of age in Nepal. Future research on its use in younger children (6-24 months) and diverse settings will enable its integration into routine growth monitoring. FUNDING: This study was funded by the German Federal Foreign Office as part of the overall funding for the development of Child Growth Monitor app. CI - (c) 2026 The Author(s). FAU - Mukherjee, Ritika AU - Mukherjee R AD - Generating Research Insights for Development Council (GRID Council), H 54, Sector 63, Noida, Uttar Pradesh, 201309, India. FAU - Kaushik, Shivangi AU - Kaushik S AD - Welthungerhilfe, Deutsche Welthungerhilfe e.V. Friedrich-Ebert-Strasse 1, 53173, Bonn, Germany. FAU - Salah, Hamza AU - Salah H AD - Generating Research Insights for Development Council (GRID Council), H 54, Sector 63, Noida, Uttar Pradesh, 201309, India. FAU - Gupta, Ankit Kumar AU - Gupta AK AD - Child Growth Monitor, Welthungerhilfe, House No- 144, Shivam Footwear, Banda Road, Atarra, Banda, Uttar Pradesh, 210201, India. FAU - Sharma, Divita AU - Sharma D AD - Generating Research Insights for Development Council (GRID Council), H 54, Sector 63, Noida, Uttar Pradesh, 201309, India. FAU - Kahraman, Miriam AU - Kahraman M AD - Deutsche Welthungerhilfe e.V., Deutsche Welthungerhilfe e.V. Friedrich-Ebert-Strasse 1, 53173, Bonn, Germany. FAU - Vadyadagaya, Anupama AU - Vadyadagaya A AD - Child Growth Monitor, WHH, #12-513D1, Bantwal, Dakshina Kannada, Karnataka, 574219, India. FAU - Ali, Nasrullah AU - Ali N AD - Deutsche Welthungerhilfe e.V., Deutsche Welthungerhilfe e.V. Friedrich-Ebert-Strasse 1, 53173, Bonn, Germany. FAU - Rijal, Mahesh AU - Rijal M AD - Welthungerhilfe Nepal, 341, Kalika Mandir Marga, Sanepa, Lalitpur - 02, Nepal. FAU - Rai, Sampurna AU - Rai S AD - NTAG, Ukti Marg, Maitighar Height Kathmandu, Bagmati, 44600, Nepal. FAU - Mohapatra, Archisman AU - Mohapatra A AD - Generating Research Insights for Development Council (GRID Council), H 54, Sector 63, Noida, Uttar Pradesh, 201309, India. LA - eng PT - Journal Article DEP - 20260424 PL - England TA - Lancet Reg Health Southeast Asia JT - The Lancet regional health. Southeast Asia JID - 9918419282806676 PMC - PMC13129374 OTO - NOTNLM OT - Artificial intelligence OT - Child nutrition OT - Digital anthropometry OT - Growth monitoring OT - Health technology OT - Malnutrition OT - South-East Asia COIS- SK, AG, MK, NA, and SR were members of the CGM study team but were not involved in the formal data analysis for this manuscript. The authors declare no other competing interests. EDAT- 2026/05/04 12:34 MHDA- 2026/05/04 12:35 PMCR- 2026/04/24 CRDT- 2026/05/04 06:41 PHST- 2026/01/16 00:00 [received] PHST- 2026/04/02 00:00 [revised] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/05/04 12:35 [medline] PHST- 2026/05/04 12:34 [pubmed] PHST- 2026/05/04 06:41 [entrez] PHST- 2026/04/24 00:00 [pmc-release] AID - S2772-3682(26)00059-4 [pii] AID - 100774 [pii] AID - 10.1016/j.lansea.2026.100774 [doi] PST - epublish SO - Lancet Reg Health Southeast Asia. 2026 Apr 24;48:100774. doi: 10.1016/j.lansea.2026.100774. eCollection 2026 May. PMID- 42079901 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260504 LR - 20260926 IS - 2666-2736 (Electronic) IS - 2666-2736 (Linking) VI - 30 DP - 2026 Apr TI - Retrograde perfusion of the dorsalis pedis artery versus traditional distal perfusion catheter use in venoarterial extracorporeal membrane oxygenation. PG - 101714 LID - 10.1016/j.xjon.2026.101714 [doi] LID - 101714 AB - OBJECTIVE: Limb ischemia is a persistent problem in femoral venoarterial extracorporeal membrane oxygenation (VA-ECMO), with clinically significant adverse events and/or poor outcomes occurring in 10% to 70% of patients. The Extracorporeal Life Support Organization recommends the use of a distal perfusion catheter (DPC), but in patients in whom proximal femoral artery access is challenging or no longer viable, a more distal DPC placement may be necessary. Using a dynamic mock flow loop of adult femoral VA-ECMO, we investigated the hemodynamic feasibility of retrograde dorsalis pedis artery DPC placement versus traditional DPC placement. METHODS: An adult femoral VA-ECMO dynamic mock flow loop was tuned to heart failure conditions. An ECMO circuit (Affinity pump with Eurosets oxygenator, 15-Fr arterial cannula in the right common femoral artery, 25-Fr contralateral venous cannula, and 6-Fr pediatric arterial cannula as DPC) was integrated into the loop. Two configurations were tested: (1) traditional anterograde DPC (right superficial femoral artery); (2) retrograde DPC of the right dorsalis pedis artery. Hemodynamic data were collected at baseline (ECMO circuit clamped) and with ECMO support at 0-3000 rpm. RESULTS: Retrograde dorsalis pedis perfusion provided distal limb hemodynamics (pressures, flows) comparable with traditional DPC placement. DPC flow (367 mL/min), right-left limb flow balance ratio, and distal limb pulsatility were comparable with both approaches while maintaining equivalent ECMO and central flows (aortic, venous). The dorsalis DPC provided retrograde flow up the right superficial femoral artery to the proximal limb (147 mL/min) and anterograde flow down the tibioperoneal trunk (252 mL/min). CONCLUSIONS: Traditional anterograde DPC is not always feasible in patients with hematoma, obesity, infection, severe peripheral vasculopathy, and/or anatomical variation. We demonstrated experimentally that retrograde DPC of the dorsalis pedis artery may be a viable hemodynamic alternative to traditional DPC placement in femoral VA-ECMO to prevent distal limb ischemia. CI - (c) 2026 The Author(s). FAU - Lytle, Isabelle R AU - Lytle IR AD - School of Medicine, University of Louisville, Louisville, Ky. FAU - Crane, Joshua G AU - Crane JG AD - Department of Surgery, University of Louisville, Louisville, Ky. AD - Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky. FAU - Slaughter, Mark S AU - Slaughter MS AD - Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky. FAU - Koenig, Steven C AU - Koenig SC AD - Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky. AD - Department of Bioengineering, University of Louisville, Louisville, Ky. FAU - Monreal, Gretel AU - Monreal G AD - Department of Cardiovascular and Thoracic Surgery, University of Louisville, Louisville, Ky. LA - eng PT - Journal Article DEP - 20260305 PL - Netherlands TA - JTCVS Open JT - JTCVS open JID - 101768541 PMC - PMC13131172 OTO - NOTNLM OT - DPC OT - VA-ECMO OT - distal perfusion catheter OT - dorsalis pedis artery OT - limb ischemia OT - mock flow loop OT - venoarterial extracorporeal membrane oxygenation COIS- Drs Monreal, Koenig, and Slaughter are investigators on National Institutes of Health (NIH) grant R44HL144214, unrelated to this project. Dr Koenig is an investigator on NIH grant R01HL150346, unrelated to this project. Dr Slaughter is an advisor to NorthStar Medical and is on the advisory board of Medtronic. Dr Monreal is an investigator on a grant from Abiomed, unrelated to this project. Dr Monreal has received funds from the National Board of Medical Examiners (NBME) Medical Student Organization Assistance Initiative to support the Innovation in Medicine medical student interest group at the University of Louisville, honoraria from the European Science Foundation, and is supported in part by a gift from Robert M. Prizant to the Legacy Foundation of Kentuckiana. All other authors reported no conflicts of interest. The Journal policy requires editors and reviewers to disclose conflicts of interest and to decline handling or reviewing manuscripts for which they may have a conflict of interest. The editors and reviewers of this article have no conflicts of interest. EDAT- 2026/05/04 12:34 MHDA- 2026/05/04 12:35 PMCR- 2026/03/05 CRDT- 2026/05/04 06:39 PHST- 2026/01/06 00:00 [received] PHST- 2026/02/24 00:00 [revised] PHST- 2026/02/26 00:00 [accepted] PHST- 2026/05/04 12:35 [medline] PHST- 2026/05/04 12:34 [pubmed] PHST- 2026/05/04 06:39 [entrez] PHST- 2026/03/05 00:00 [pmc-release] AID - S2666-2736(26)00137-3 [pii] AID - 101714 [pii] AID - 10.1016/j.xjon.2026.101714 [doi] PST - epublish SO - JTCVS Open. 2026 Mar 5;30:101714. doi: 10.1016/j.xjon.2026.101714. eCollection 2026 Apr. PMID- 42079597 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260817 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - RAR and infant mortality: a crucial link in cardiac surgery outcomes. PG - 1806409 LID - 10.3389/fimmu.2026.1806409 [doi] LID - 1806409 AB - BACKGROUND: In-hospital mortality remains a significant concern in infant cardiac surgery, yet precise risk stratification tools are lacking. The prognostic value of the red cell distribution width-to-albumin ratio (RAR)-a composite marker of inflammation and nutritional status-remains unestablished in this population. This study aimed to examine the association between RAR and in-hospital mortality in infants undergoing cardiac surgery. METHODS: This work constitutes a retrospective observational cohort analysis. The study population comprised infants admitted to Guangdong Provincial People's Hospital for cardiac surgery from January 2017 through October 2021.The optimal cut-off value for the RAR was determined to be 1.35 fL/(g/L) using the Youden index method. Based on this threshold, all participants were categorized into a high-RAR group and a low-RAR group. The relationship between RAR levels and mortality during hospitalization was then examined through multiple analytical approaches, including logistic regression, subgroup analyses, and modeling with restricted cubic splines (RCS).The predictive performance of the RAR was further evaluated through an analysis of the receiver operating characteristic (ROC) curve. RESULTS: Mortality rates in this surgical cohort increased with higher RAR values. A consistent relationship linking the RAR to mortality was observed regardless of whether this biomarker was incorporated into statistical models as a continuous measure or a categorical parameter. Among 3634 patients, logistic regression analysis indicated that infants with RAR > 1.35 fL/(g/L) had a significantly higher mortality risk compared to those with RAR /= 25 kg/m(2) for intergroup comparisons, comprehensively evaluating the association between daily steps and various indicators. RESULTS: Among PCOS patients, 42.9% were sedentary, while only 8.8% were active or highly active. Indicators significantly correlated with step count in the correlation analysis underwent further multivariate linear regression analysis. RCS analysis further validated the positive linear relationship between HDL and daily step count in PCOS patients (P for non-linear = 0.125). For PCOS patients without obesity, daily step count showed linear relationships with TG (P for non-linear = 0.211), HDL (P for non-linear = 0.255), and VAI (P for non-linear = 0.839). Additionally, daily steps showed linear relationships with body fat percentage (BFP, p=0.033, R (2) = 0.454), android fat percentage (p=0.045, R (2) = 0.413), Android/Gynoid ratio (A/G, p=0.041, R (2) = 0.425), fat mass index (FMI, p=0.007, R (2) = 0.671), and percent trunk fat (PTF, p=0.041, R (2) = 0.427). CONCLUSION: Daily steps exhibits a beneficial association with lipid and body fat metabolism in PCOS patients without obesity, making it a viable indicator for quantifying physical activity that can be incorporated into PCOS patient management. CI - Copyright (c) 2026 Wang, Zhang, Ma, Luo and Li. FAU - Wang, Tianmei AU - Wang T AD - Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Zhang, LiJuan AU - Zhang L AD - Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Ma, Liya AU - Ma L AD - Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Luo, Xiaodong AU - Luo X AD - Department of Gynecology and Obstetrics, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China. FAU - Li, Cong AU - Li C AD - Department of Gynecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. LA - eng PT - Journal Article DEP - 20260416 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/physiopathology/metabolism/therapy MH - Adolescent MH - Young Adult MH - Adult MH - *Obesity/complications/physiopathology MH - *Exercise/physiology MH - Body Mass Index MH - *Walking/physiology PMC - PMC13128351 OTO - NOTNLM OT - PCOS OT - abdominal fat OT - daily steps OT - metabolism OT - walking COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/04 12:33 MHDA- 2026/05/04 12:34 PMCR- 2026/04/16 CRDT- 2026/05/04 06:16 PHST- 2025/11/11 00:00 [received] PHST- 2026/03/20 00:00 [revised] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/05/04 12:34 [medline] PHST- 2026/05/04 12:33 [pubmed] PHST- 2026/05/04 06:16 [entrez] PHST- 2026/04/16 00:00 [pmc-release] AID - 10.3389/fendo.2026.1744228 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Apr 16;17:1744228. doi: 10.3389/fendo.2026.1744228. eCollection 2026. PMID- 42077453 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260818 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Development and validation of age- and gender-specific reference intervals for the triglyceride-glucose index in a large Chinese healthy adult population. PG - 1793587 LID - 10.3389/fendo.2026.1793587 [doi] LID - 1793587 AB - BACKGROUND: The triglyceride-glucose (TyG) index is a recognized surrogate marker of insulin resistance. However, validated reference intervals (RIs) for the TyG index in large, general healthy populations are currently lacking, limiting its standardized application in clinical practice. METHODS: This retrospective study established and validated TyG index RIs using data from adults (>/=18 years) undergoing routine health examinations. The derivation cohort included individuals without known diabetes, dyslipidemia, or obesity. The TyG index was calculated as ln[fasting triglyceride (mg/dL) x fasting blood glucose (mg/dL)/2]. After outlier exclusion, we analyzed the age-TyG relationship using restricted cubic splines and threshold analysis to determine optimal age stratification. Gender- and age-specific RIs were defined as the 2.5th-97.5th percentiles. An independent cohort of 127,143 healthy individuals was used for validation, with success defined as <10% of values falling outside the proposed RIs. RESULTS: A total of 201,623 individuals were initially screened for the derivation cohort. Analysis revealed a significant nonlinear relationship between TyG and age, with an inflection point at 64.21 years, justifying stratification into 18-64 and >/=64-year groups. The overall RI was 7.47-8.90. Stratified RIs were: 7.47-8.91 for males aged 18-64, 7.46-8.90 for females aged 18-64, 7.44-8.90 for males aged >/=64, and 7.50-8.90 for females aged >/=64. In the independent validation cohort, only 4.76% to 5.37% of values fell outside the corresponding RIs, confirming their robustness. CONCLUSION: This study establishes and validates age- and gender-stratified reference intervals for the TyG index in a large Chinese healthy population. These intervals, benchmarked against a critical age threshold of 64 years, provide a reliable standard for clinical interpretation and enhance the utility of the TyG index in metabolic risk assessment. CI - Copyright (c) 2026 Huang, Qin, Lu, Li, Wang, He, Mai, Lu, Lu, Huang, Zheng, Zhang and Feng. FAU - Huang, Shanshan AU - Huang S AD - Department of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. FAU - Qin, Liming AU - Qin L AD - Department of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. FAU - Lu, Chuanfu AU - Lu C AD - Department of General Internal Medicine, Shibu Health Center, Nanning, Guangxi, China. FAU - Li, Weinan AU - Li W AD - Department of General Internal Medicine, Shibu Health Center, Nanning, Guangxi, China. FAU - Wang, Yibo AU - Wang Y AD - Department of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. FAU - He, Dan AU - He D AD - Department of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. FAU - Mai, Yuni AU - Mai Y AD - Department of General Internal Medicine, Shibu Health Center, Nanning, Guangxi, China. FAU - Lu, Na AU - Lu N AD - Department of General Internal Medicine, Shibu Health Center, Nanning, Guangxi, China. FAU - Lu, Qiuyu AU - Lu Q AD - Department of General Internal Medicine, Shibu Health Center, Nanning, Guangxi, China. FAU - Huang, Shiwei AU - Huang S AD - Department of General Internal Medicine, Shibu Health Center, Nanning, Guangxi, China. FAU - Zheng, Xiaowen AU - Zheng X AD - Department of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. FAU - Zhang, Jianfeng AU - Zhang J AD - Department of Emergency Medicine, Wuming Hospital of Guangxi Medical University, Nanning, Guangxi, China. FAU - Feng, Jihua AU - Feng J AD - Department of Emergency Medicine, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260416 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) RN - 0 (Triglycerides) RN - Chinese people SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Age Factors MH - Biomarkers/blood MH - *Blood Glucose/analysis/metabolism MH - China/epidemiology MH - Insulin Resistance MH - Reference Values MH - Retrospective Studies MH - Sex Factors MH - *Triglycerides/blood MH - East Asian People PMC - PMC13128429 OTO - NOTNLM OT - Chinese population OT - age OT - gender OT - reference intervals OT - triglyceride-glucose index COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/04 12:34 MHDA- 2026/05/04 12:35 PMCR- 2026/04/16 CRDT- 2026/05/04 06:16 PHST- 2026/01/22 00:00 [received] PHST- 2026/03/25 00:00 [revised] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/05/04 12:35 [medline] PHST- 2026/05/04 12:34 [pubmed] PHST- 2026/05/04 06:16 [entrez] PHST- 2026/04/16 00:00 [pmc-release] AID - 10.3389/fendo.2026.1793587 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Apr 16;17:1793587. doi: 10.3389/fendo.2026.1793587. eCollection 2026. PMID- 42076786 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1365-2826 (Electronic) IS - 0953-8194 (Linking) VI - 38 IP - 5 DP - 2026 May TI - Metabolic-endocrine correlates of gut-brain axis mediators in polycystic ovary syndrome: A case-control study. PG - e70180 LID - 10.1111/jne.70180 [doi] AB - Polycystic ovary syndrome (PCOS) is increasingly recognized as a neuro-metabolic disorder involving disrupted signaling between the brain-gut axis and reproductive system. Peptides such as kisspeptin, ghrelin, serotonin, and peptide tyrosine tyrosine (PYY) are emerging as integrators of metabolic and endocrine function, yet their coordinated alterations in PCOS and relevance to metabolic risk remain underexplored. Therefore, we investigated the combined pattern of serum kisspeptin, ghrelin, serotonin, and PYY in PCOS, and their associations with metabolic and hormonal indices. In this case-control study, a total of 190 women aged 18-40 years were included between June 2023 and June 2024, comprising 96 women diagnosed with PCOS according to 2003 Rotterdam criteria and 94 age-matched healthy controls. Serum levels of kisspeptin, ghrelin, serotonin, and PYY were measured using ELISA. Secondary assessments included clinical, metabolic, hormonal, and inflammatory parameters. Women with PCOS had significantly higher serum kisspeptin levels and lower ghrelin and serotonin levels compared to controls (p < .05), while PYY levels were similar between the groups. Kisspeptin was inversely correlated with ghrelin (r = -.237, p = .003) and serotonin (r = -.303, p < .001). These peptides also showed significant associations with metabolic indices such as fasting insulin, glucose, HOMA-IR, triglyceride-glucose (TyG), and TyG-BMI ratios. In regression models adjusted for BMI, lower ghrelin (OR = 0.661, p = .008) and serotonin (OR = 0.814, p = .016) levels were independently associated with higher odds of PCOS. Exploratory receiver operating characteristic (ROC) analysis showed that kisspeptin demonstrated moderate discriminatory performance for PCOS (AUC = 0.768; 95% CI: 0.696-0.839), with 82.4% sensitivity and 59% specificity, whereas ghrelin, serotonin, and PYY showed lower AUCs, reflecting limited stand-alone discriminatory ability. Elevated kisspeptin with concomitant reductions in ghrelin and serotonin define a reproducible peptide signature in PCOS, linking neuroendocrine perturbations to measurable metabolic risk, independent of obesity. While kisspeptin shows greater biological separation between groups, none of the peptides alone are sufficient for diagnostic classification; instead, they indicate the central role of hypothalamic-gut axis dysfunction, particularly in lean PCOS phenotypes. CI - (c) 2026 British Society for Neuroendocrinology. FAU - Bashir, Rohina AU - Bashir R AD - Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India. AD - Department of Clinical Research, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India. FAU - Asrar, Mir AU - Asrar M AD - CSIR-Indian Institute of Integrative Medicine, Jammu, India. FAU - Kamboj, Saloni AU - Kamboj S AD - Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India. FAU - Yousuf, Aadil AU - Yousuf A AD - Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India. AD - Department of Clinical Research, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India. FAU - Arif, Tasleem AU - Arif T AD - Department of Clinical Research, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India. FAU - Jahan, Nusrat AU - Jahan N AD - Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India. AD - Department of Clinical Research, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India. FAU - Ganie, Mohd Ashraf AU - Ganie MA AUID- ORCID: 0000-0002-7649-6749 AD - Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India. AD - Department of Clinical Research, Sher-i-Kashmir Institute of Medical Sciences, Srinagar, India. LA - eng GR - R.12014/63/2022-HR./Department of Health Research (DHR)/ PT - Journal Article PL - United States TA - J Neuroendocrinol JT - Journal of neuroendocrinology JID - 8913461 RN - 0 (Ghrelin) RN - 333DO1RDJY (Serotonin) RN - 106388-42-5 (Peptide YY) RN - 0 (Kisspeptins) SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/metabolism/blood/physiopathology MH - Case-Control Studies MH - *Ghrelin/blood MH - *Serotonin/blood MH - *Peptide YY/blood MH - Adult MH - Young Adult MH - *Kisspeptins/blood MH - *Brain/metabolism MH - Adolescent OTO - NOTNLM OT - ghrelin OT - gut hormones OT - kisspeptin OT - metabolic regulation OT - polycystic ovarian syndrome EDAT- 2026/05/04 06:32 MHDA- 2026/05/04 06:33 CRDT- 2026/05/04 01:25 PHST- 2026/01/19 00:00 [revised] PHST- 2025/08/08 00:00 [received] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/05/04 06:33 [medline] PHST- 2026/05/04 06:32 [pubmed] PHST- 2026/05/04 01:25 [entrez] AID - 10.1111/jne.70180 [doi] PST - ppublish SO - J Neuroendocrinol. 2026 May;38(5):e70180. doi: 10.1111/jne.70180. PMID- 42076671 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 8 DP - 2026 Apr 21 TI - On-Field Assessment of Joint Load in Football Using Machine Learning (Part II). LID - 10.3390/s26082562 [doi] LID - 2562 AB - Anterior cruciate ligament (ACL) injury risk is elevated in female youth football, yet knee joint loading has mainly been studied under controlled laboratory conditions. This limits understanding of how injury risk emerges during realistic match situations. This study provided a field-based kinetic characterization of football-specific movements by estimating knee abduction moments (KAMs) using wearable sensors and machine learning. Fifty-two highly talented female youth players performed agility tasks during training, including structured exercises (F-EX) and game-based play (F-GAME). Full-body kinematics were collected with inertial measurement units, and a validated support vector machine model, trained on synchronized motion capture and force plate data, classified trials as high or low KAM. Across 662 change-in-direction trials, 9-12% were classified as high KAM in both conditions, indicating that potentially high-risk loading regularly occurs during routine actions. High KAM trials showed reduced knee and pelvis flexion, increased hip flexion, and greater pelvis rotation toward the cutting direction, reflecting upright, stiff movement strategies. Performance analyses revealed smaller cut angles in exercises and greater approach acceleration in game play, without differences in peak velocity. These findings demonstrate the feasibility of field-based kinetic screening and support a complex-systems perspective on ACL injury risk. FAU - Benjaminse, Anne AU - Benjaminse A AUID- ORCID: 0000-0001-8528-1136 AD - Department of Human Movement Sciences, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands. FAU - Mendicino, Margherita AU - Mendicino M AUID- ORCID: 0009-0009-5969-5832 AD - 2nd Orthopaedic and Traumatological Clinic, IRCCS Rizzoli Orthopaedic Institute, 40136 Bologna, Italy. FAU - Nijmeijer, Eline M AU - Nijmeijer EM AUID- ORCID: 0000-0002-4304-5466 AD - Department of Human Movement Sciences, University Medical Center Groningen, University of Groningen, 9713 AV Groningen, The Netherlands. FAU - Margheriti, Pietro AU - Margheriti P AUID- ORCID: 0009-0003-7343-4248 AD - 2nd Orthopaedic and Traumatological Clinic, IRCCS Rizzoli Orthopaedic Institute, 40136 Bologna, Italy. FAU - Gokeler, Alli AU - Gokeler A AUID- ORCID: 0000-0002-6427-4225 AD - Exercise Science and Neuroscience Unit, Department of Exercise and Health, Paderborn University, 33098 Paderborn, Germany. FAU - Di Paolo, Stefano AU - Di Paolo S AUID- ORCID: 0000-0002-1761-7352 AD - Education and Research Department, Isokinetic Medical Group, FIFA Medical Centre of Excellence, 40132 Bologna, Italy. LA - eng GR - 016.186.114/NWO ZonMW/ PT - Journal Article DEP - 20260421 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - Female MH - *Machine Learning MH - Biomechanical Phenomena MH - Anterior Cruciate Ligament Injuries/physiopathology MH - *Knee Joint/physiology MH - *Soccer/physiology MH - Adolescent PMC - PMC13119674 OTO - NOTNLM OT - ACL injury OT - agility OT - female youth athletes OT - injury risk profiling OT - sensors COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:32 MHDA- 2026/05/04 06:33 PMCR- 2026/04/21 CRDT- 2026/05/04 01:22 PHST- 2026/02/23 00:00 [received] PHST- 2026/04/13 00:00 [revised] PHST- 2026/04/17 00:00 [accepted] PHST- 2026/05/04 06:33 [medline] PHST- 2026/05/04 06:32 [pubmed] PHST- 2026/05/04 01:22 [entrez] PHST- 2026/04/21 00:00 [pmc-release] AID - s26082562 [pii] AID - sensors-26-02562 [pii] AID - 10.3390/s26082562 [doi] PST - epublish SO - Sensors (Basel). 2026 Apr 21;26(8):2562. doi: 10.3390/s26082562. PMID- 42076609 OWN - NLM STAT- MEDLINE DCOM- 20260526 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 8 DP - 2026 Apr 18 TI - Sagittal-Plane Knee Flexion Moment Estimation Using a Lightweight Deep Learning Framework Based on Sequential Surface EMG Feature Frames. LID - 10.3390/s26082500 [doi] LID - 2500 AB - Knee joint moment is an important biomechanical parameter for sports assessment, rehabilitation monitoring, and human-machine interaction. However, direct measurement is often restricted to laboratory-based settings. Surface electromyography (sEMG) offers a non-invasive alternative for indirect joint moment estimation, but many existing deep learning models remain too computationally demanding for potential wearable edge deployment. To address this gap, this study proposes Topo2DCNN-LSTM, a lightweight two-dimensional (2D) convolutional neural network model, designed for sagittal-plane knee flexion moment estimation. The model used a feature-based sequential representation, transforming raw sEMG signals into compact Root Mean Square (RMS) feature frames. The input was processed by a lightweight 2D convolutional neural network (CNN) encoder and paired with long short-term memory (LSTM) units. The model was trained on a public walking dataset of healthy subjects with synchronized sEMG and joint kinetics at two treadmill speeds. When compared with selected deep learning baselines, the quantized model achieved a mean RMS Error of 0.088 +/- 0.020 Nm/kg at 1.2 m/s and 0.114 +/- 0.034 Nm/kg at 1.8 m/s. On a SparkFun Thing Plus-SAMD51, it achieved an average inference latency of 28 ms using 71,316 bytes of random-access memory (RAM) and 257,172 bytes of flash. These results support its use as a proof of concept for personalized unilateral knee moment estimation with isolated on-device inference feasibility under resource-constrained and limited walking conditions. FAU - Zhuo, Yuanzhi AU - Zhuo Y AUID- ORCID: 0009-0007-6709-2818 AD - Biomedical Engineering Department, School of Engineering, STEM College, RMIT University, Melbourne, VIC 3000, Australia. FAU - Pranata, Adrian AU - Pranata A AUID- ORCID: 0000-0002-7877-1679 AD - School of Health and Biomedical Science, RMIT University, Bundoora, VIC 3082, Australia. FAU - Cheng, Chi-Tsun AU - Cheng CT AUID- ORCID: 0000-0003-3306-6148 AD - Mechanical, Manufacturing and Mechatronic Engineering Department, School of Engineering, STEM College, RMIT University, Melbourne, VIC 3000, Australia. FAU - Pang, Toh Yen AU - Pang TY AUID- ORCID: 0000-0002-4766-3042 AD - Biomedical Engineering Department, School of Engineering, STEM College, RMIT University, Melbourne, VIC 3000, Australia. LA - eng PT - Journal Article DEP - 20260418 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - *Knee Joint/physiology MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Datasets as Topic MH - *Electromyography/methods MH - *Deep Learning MH - Walking MH - *Range of Motion, Articular MH - Biomechanical Phenomena PMC - PMC13120070 OTO - NOTNLM OT - continuous motion estimation OT - deep learning OT - feature engineering OT - gait analysis OT - joint moment estimation OT - knee moment OT - microcontroller OT - surface electromyography OT - wearable sensor COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:32 MHDA- 2026/05/04 06:33 PMCR- 2026/04/18 CRDT- 2026/05/04 01:22 PHST- 2026/02/16 00:00 [received] PHST- 2026/04/09 00:00 [revised] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/05/04 06:33 [medline] PHST- 2026/05/04 06:32 [pubmed] PHST- 2026/05/04 01:22 [entrez] PHST- 2026/04/18 00:00 [pmc-release] AID - s26082500 [pii] AID - sensors-26-02500 [pii] AID - 10.3390/s26082500 [doi] PST - epublish SO - Sensors (Basel). 2026 Apr 18;26(8):2500. doi: 10.3390/s26082500. PMID- 42075650 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 62 IP - 4 DP - 2026 Apr 17 TI - The Relationship Between Body Posture and Psychophysical Functioning in Children with Obesity: A Narrative Literature Review and Future Research Perspective Related to Preliminary Research Concept. LID - 10.3390/medicina62040779 [doi] LID - 779 AB - Childhood obesity is a growing global health problem with significant biomechanical and psychosocial consequences. While many studies have examined these domains separately, few integrate postural abnormalities, psychophysical functioning, and lifestyle factors within a single framework. This narrative review synthesises the literature published between 2005 and 2025 to summarise current evidence and identify research gaps. The findings indicate that overweight and obesity increase the risk of musculoskeletal deviations such as genu valgum, flat feet, and increased lumbar lordosis, as well as altered gait biomechanics and reduced motor competence. Excess body weight is also associated with lower self-esteem, negative body image, depressive symptoms, and reduced health-related quality of life in children and adolescents. These outcomes appear to be influenced by modifiable lifestyle factors, including parental health behaviours, sleep patterns, and screen time, although reported associations remain inconsistent. Notably, few studies address biomechanical, psychological, and environmental factors simultaneously, which limits the understanding of their interactions. To address this gap, a prospective observational study of 250-300 children aged 7-17 years is proposed. The study will combine objective postural assessments, validated psychometric tools, and lifestyle analyses at baseline and after a 12-14-month follow-up. This integrated approach aims to identify postural compensation patterns, psychosocial risk trajectories, and modifiable behavioural predictors associated with childhood obesity, supporting the development of early preventive and interdisciplinary interventions. FAU - Korzan, Kornelia AU - Korzan K AUID- ORCID: 0009-0000-8663-145X AD - Department of Physiotherapy, Faculty of Health Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland. AD - Doctoral School, Medical University of Silesia, 40-055 Katowice, Poland. FAU - Czepczor-Bernat, Kamila AU - Czepczor-Bernat K AUID- ORCID: 0000-0002-1707-0000 AD - Department of Pediatrics, Pediatric Obesity and Metabolic Bone Diseases, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland. FAU - Matusik, Pawel AU - Matusik P AD - Department of Pediatrics, Pediatric Obesity and Metabolic Bone Diseases, Faculty of Medical Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland. FAU - Brzek, Anna AU - Brzek A AUID- ORCID: 0000-0002-2321-2888 AD - Department of Physiotherapy, Faculty of Health Sciences in Katowice, Medical University of Silesia, 40-055 Katowice, Poland. LA - eng GR - UDA-FESL. 10.25-12.01.05/FB/23-00; BNW-NWD/894/2024/FE SL project entitled "Supporting the region's transformation by strengthening the capacity of the Doctoral School of the Medical University of Silesia in Katowice"/ PT - Journal Article PT - Review DEP - 20260417 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 SB - IM MH - Humans MH - Child MH - *Posture/physiology MH - Adolescent MH - *Pediatric Obesity/psychology/complications/physiopathology MH - Female MH - Male MH - Quality of Life/psychology MH - *Psychophysics/methods PMC - PMC13118225 OTO - NOTNLM OT - body posture OT - childhood obesity OT - psychophysical functioning COIS- The authors declare no conflict of interest. EDAT- 2026/05/04 06:32 MHDA- 2026/05/04 06:33 PMCR- 2026/04/17 CRDT- 2026/05/04 01:19 PHST- 2026/03/02 00:00 [received] PHST- 2026/03/30 00:00 [revised] PHST- 2026/04/14 00:00 [accepted] PHST- 2026/05/04 06:33 [medline] PHST- 2026/05/04 06:32 [pubmed] PHST- 2026/05/04 01:19 [entrez] PHST- 2026/04/17 00:00 [pmc-release] AID - medicina62040779 [pii] AID - medicina-62-00779 [pii] AID - 10.3390/medicina62040779 [doi] PST - epublish SO - Medicina (Kaunas). 2026 Apr 17;62(4):779. doi: 10.3390/medicina62040779. PMID- 42075578 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 62 IP - 4 DP - 2026 Apr 7 TI - Age-Dependent Risk Factors in Pediatric Sleep-Disordered Breathing: A Large-Scale Cross-Sectional Study. LID - 10.3390/medicina62040707 [doi] LID - 707 AB - Background and Objectives: Sleep-related breathing disorders (SRBDs) are common but often underdiagnosed in children. Early identification is essential, as untreated pediatric SRBDs can lead to cognitive, metabolic, and cardiovascular complications. This study aimed to estimate the prevalence of children at risk for SRBDs, defined as those screening positive based on Pediatric Sleep Questionnaire (PSQ) scores, and to analyze the association with potential risk factors in the general pediatric population of Lithuania. Materials and Methods: This cross-sectional study included 1929 children aged 2-17 years. Parents completed a questionnaire covering demographics, health status, and the PSQ. A validated Lithuanian version of the PSQ was used, with >/=8 (40%) positive responses indicating suspected SRBDs. Results: Overall, 14.9% of children were suspected of having SRBDs, with the highest prevalence among those aged 7-11 years (17.5%), followed by 2-6 years (14.9%) and >/=12 years (12.6%) (p = 0.032). In preschoolers (2-6 years), the strongest predictors were attention deficit hyperactivity disorder (ADHD; p < 0.001, OR 4.456, 95% CI 1.992-9.968) and allergic rhinitis (p < 0.001, OR 2.268, 95% CI 1.433-3.591). In children aged 7-11 years, endocrine diseases showed the strongest association (p < 0.001, OR 13.366, 95% CI 2.914-61.313), followed by ADHD (p = 0.001, OR 5.693, 95% CI 1.981-16.363) and adenotonsillar hypertrophy (p < 0.001, OR 3.079, 95% CI 1.839-5.156). In adolescents (>/=12 years), SRBDs were primarily associated with ADHD (p < 0.001, OR 17.513, 95% CI 9.597-31.961) and endocrine diseases (p < 0.001, OR 6.214, 95% CI 2.965-13.020), while obesity remained significant (p < 0.001, OR 3.400, 95% CI 2.106-5.489). Conclusions: Approximately 15% of Lithuanian children were at risk for SRBDs. Risk factors differed by age: adenotonsillar hypertrophy in school-aged children, allergic rhinitis in preschoolers, and obesity in adolescents, whereas ADHD was associated across age groups. FAU - Oboleviciene, Gintare AU - Oboleviciene G AUID- ORCID: 0000-0001-7579-0789 AD - Pediatric Department, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50103 Kaunas, Lithuania. FAU - Mejeryte, Viktorija AU - Mejeryte V AD - Pediatric Department, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50103 Kaunas, Lithuania. FAU - Jotautaite, Norvile AU - Jotautaite N AD - Pediatric Department, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50103 Kaunas, Lithuania. FAU - Rinkeviciene, Egle AU - Rinkeviciene E AD - Pediatric Department, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50103 Kaunas, Lithuania. FAU - Katiniene, Inga AU - Katiniene I AD - Pediatric Department, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50103 Kaunas, Lithuania. FAU - Gurskis, Vaidotas AU - Gurskis V AD - Pediatric Department, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50103 Kaunas, Lithuania. FAU - Kevalas, Rimantas AU - Kevalas R AD - Pediatric Department, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50103 Kaunas, Lithuania. FAU - Miseviciene, Valdone AU - Miseviciene V AUID- ORCID: 0000-0003-4753-8011 AD - Pediatric Department, Medical Academy, Lithuanian University of Health Sciences, Eiveniu Str. 2, LT-50103 Kaunas, Lithuania. LA - eng PT - Journal Article DEP - 20260407 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Child MH - Child, Preschool MH - Lithuania/epidemiology MH - Risk Factors MH - Female MH - Male MH - *Sleep Apnea Syndromes/epidemiology/etiology MH - Adolescent MH - Surveys and Questionnaires MH - Prevalence MH - Age Factors MH - Attention Deficit Disorder with Hyperactivity/complications/epidemiology PMC - PMC13117163 OTO - NOTNLM OT - Pediatric Sleep Questionnaire OT - pediatric sleep apnea OT - prevalence of SRBDs OT - risk factors in children OT - sleep-related breathing disorders COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/07 CRDT- 2026/05/04 01:18 PHST- 2026/03/03 00:00 [received] PHST- 2026/03/22 00:00 [revised] PHST- 2026/04/03 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:18 [entrez] PHST- 2026/04/07 00:00 [pmc-release] AID - medicina62040707 [pii] AID - medicina-62-00707 [pii] AID - 10.3390/medicina62040707 [doi] PST - epublish SO - Medicina (Kaunas). 2026 Apr 7;62(4):707. doi: 10.3390/medicina62040707. PMID- 42075103 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 8 DP - 2026 Apr 20 TI - Long-Term Outcomes of Mediterranean-Adapted Crohn's Disease Exclusion Diet in Mild Pediatric Crohn's Disease: A Real-Life Study from a Referral IBD Center. LID - 10.3390/nu18081290 [doi] LID - 1290 AB - Background: Exclusive enteral nutrition (EEN) is the recommended first-line therapy for induction of remission in pediatric mild-to-moderate Crohn's disease (CD), but its restrictive nature often limits adherence and long-term sustainability. A modified version of the Crohn's Disease Exclusion Diet (CDED), integrating Mediterranean dietary principles, was developed to offer a more acceptable alternative while preserving therapeutic efficacy. Methods: We conducted a retrospective, single-center study comparing short- and long-term outcomes of a Mediterranean-adapted CDED (M-CDED) with partial enteral nutrition (PEN) versus standard EEN in children with mild-to-moderate CD. Clinical remission was assessed after 8 and 16 weeks, while long-term outcomes were assessed after 1 and 2 years. Results: Data collected from thirty-two patients were analyzed (EEN, 14; M-CDED, 18). Clinical remission rates were comparable after 8 weeks (92.8% EEN vs. 94.4% M-CDED) and 16 weeks (100% in both groups). However, at 12 and 24 months, M-CDED was associated with significantly higher rates of clinical and biochemical remission and a markedly lower need for biologic drugs (12-month biologic initiation: 50% EEN vs. 11.1% M-CDED; p = 0.01). Adherence to M-CDED was excellent throughout follow-up. Conclusions: M-CDED with PEN appears to be as effective as EEN for remission induction, with improved long-term disease control and reduced therapeutic escalation. These findings support the feasibility of M-CDED as a sustainable option for long-term management of pediatric CD. Prospective studies are needed to confirm these results. FAU - Alvisi, Patrizia AU - Alvisi P AD - Pediatric Gastroenterology Unit, Department of Paediatrics, Ospedale Maggiore, Azienda USL, 40133 Bologna, Italy. FAU - Valerii, Maria Chiara AU - Valerii MC AD - Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy. FAU - Perre, Enrico AU - Perre E AD - Specialty School of Pediatrics, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy. FAU - Barbieri, Gilda AU - Barbieri G AD - Pediatric Gastroenterology Unit, Department of Paediatrics, Ospedale Maggiore, Azienda USL, 40133 Bologna, Italy. FAU - Rizzello, Fernando AU - Rizzello F AD - IBD Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, 40138 Bologna, Italy. FAU - Congiu, Marco AU - Congiu M AD - Pediatric Unit, Department of Paediatrics, Ospedale Maggiore, Azienda USL, 40133 Bologna, Italy. FAU - Pranzetti, Arianna AU - Pranzetti A AD - Specialty School of Pediatrics, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy. FAU - Dussias, Nikolas Kostantine AU - Dussias NK AUID- ORCID: 0000-0003-1338-9361 AD - IBD Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, 40138 Bologna, Italy. FAU - Sbravati, Francesca AU - Sbravati F AUID- ORCID: 0000-0003-4606-9145 AD - Pediatric Gastroenterology Unit, Department of Paediatrics, Ospedale Maggiore, Azienda USL, 40133 Bologna, Italy. FAU - Imbesi, Veronica AU - Imbesi V AD - IBD Unit, IRCCS Azienda Ospedaliero-Universitaria of Bologna, 40138 Bologna, Italy. FAU - Spisni, Enzo AU - Spisni E AUID- ORCID: 0000-0002-8525-2981 AD - Department of Biological, Geological and Environmental Sciences, Alma Mater Studiorum, University of Bologna, 40126 Bologna, Italy. FAU - Labriola, Flavio AU - Labriola F AD - Pediatric Gastroenterology Unit, Department of Paediatrics, Ospedale Maggiore, Azienda USL, 40133 Bologna, Italy. LA - eng PT - Journal Article DEP - 20260420 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - Pediatric Crohn's disease SB - IM MH - Humans MH - *Crohn Disease/diet therapy MH - Female MH - Retrospective Studies MH - Male MH - Child MH - *Diet, Mediterranean MH - *Enteral Nutrition/methods MH - Adolescent MH - Remission Induction MH - Treatment Outcome MH - Elimination Diets PMC - PMC13119448 OTO - NOTNLM OT - Mediterranean exclusion diet OT - exclusive enteral nutrition OT - pediatric Crohn's disease COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:32 MHDA- 2026/05/04 06:33 PMCR- 2026/04/20 CRDT- 2026/05/04 01:17 PHST- 2026/02/24 00:00 [received] PHST- 2026/04/07 00:00 [revised] PHST- 2026/04/14 00:00 [accepted] PHST- 2026/05/04 06:33 [medline] PHST- 2026/05/04 06:32 [pubmed] PHST- 2026/05/04 01:17 [entrez] PHST- 2026/04/20 00:00 [pmc-release] AID - nu18081290 [pii] AID - nutrients-18-01290 [pii] AID - 10.3390/nu18081290 [doi] PST - epublish SO - Nutrients. 2026 Apr 20;18(8):1290. doi: 10.3390/nu18081290. PMID- 42075098 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260926 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 8 DP - 2026 Apr 18 TI - Social Inequalities in T2DM-Related Risk Patterns and Diabetes-Related Knowledge Among Hungarian Secondary School Students Aged 16-20 Years: A Cross-Sectional Study Using an Adapted FINDRISC-Based Screening Framework. LID - 10.3390/nu18081286 [doi] LID - 1286 AB - BACKGROUND/OBJECTIVES: Type 2 diabetes mellitus (T2DM) is a major public health challenge, and several lifestyle-related factors associated with later T2DM may already emerge during the secondary school years. Socioeconomic status (SES), nutrition-related behaviors, physical activity, and basic diabetes-related knowledge may shape these early risk-related patterns. This study examined the relationships between SES, adapted FINDRISC-based T2DM-related risk patterns, and diabetes-related knowledge among Hungarian secondary school students aged 16-20 years. METHODS: A nationwide, cross-sectional questionnaire survey was conducted among students attending Hungarian Baptist secondary schools (N = 1585). SES was classified by Two-Step cluster analysis based on parental education, parental occupation, number of books in the household, and frequency of travel abroad. Relative T2DM-related risk patterns were described using an age-adapted FINDRISC-based screening approach, and basic diabetes-related knowledge was assessed using a 12-item questionnaire. Associations were examined using cross-tabulation and regression analyses in SPSS version 27.0. RESULTS: Most respondents fell into the lower categories of the adapted FINDRISC-based screening framework, whereas 7.4% were classified into the moderate or high adapted FINDRISC-based screening categories. SES was significantly associated with adapted FINDRISC-based screening categories (p < 0.001). Compared with the medium-SES group, students in the low-SES group had higher odds of belonging to a higher adapted FINDRISC-based screening category (OR = 1.81; 95% CI: 1.27-2.57; p = 0.001). SES was also significantly associated with basic diabetes-related knowledge profiles (p = 0.015); students with high SES were less likely to be in the low-knowledge group than in the high-knowledge group (OR = 0.62; p = 0.039). CONCLUSIONS: Social inequalities in T2DM-related risk patterns and diabetes-related knowledge are already visible among secondary school students aged 16-20 years. The adapted FINDRISC-based approach may be useful as a school-based, non-invasive descriptive screening framework for characterizing relative T2DM-related risk patterns, but it is not a validated risk prediction instrument for this age group. FAU - Fuzesi, Brigitta AU - Fuzesi B AD - Faculty of Health Sciences, Doctoral School, Semmelweis University, 1085 Budapest, Hungary. AD - National Federation of Diabetes Associations, 1116 Budapest, Hungary. FAU - Porzse, Gabor Ferenc AU - Porzse GF AD - Department of Social Sciences, Faculty of Health Sciences, Semmelweis University, 1085 Budapest, Hungary. FAU - Bornemissza, Krisztina Antonia AU - Bornemissza KA AD - Institute of Sociology, Faculty of Humanities and Social Sciences, Pazmany Peter Catholic University, 1088 Budapest, Hungary. FAU - Horkai, Anita AU - Horkai A AD - Department of Social Sciences, Faculty of Health Sciences, Semmelweis University, 1085 Budapest, Hungary. FAU - Sallai, Judit AU - Sallai J AD - Central Department of Anaesthesiology and Intensive Care, North Pest Central Hospital-Honved Hospital, 1134 Budapest, Hungary. FAU - Feith, Helga Judit AU - Feith HJ AUID- ORCID: 0000-0001-8855-5059 AD - Department of Social Sciences, Faculty of Health Sciences, Semmelweis University, 1085 Budapest, Hungary. LA - eng GR - 2023-2.1.2-KDP-2023-00016/Ministry of Culture and Innovation of Hungary from the National Research, Development and Innovation Fund/ PT - Journal Article DEP - 20260418 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Cross-Sectional Studies MH - Male MH - Female MH - *Diabetes Mellitus, Type 2/epidemiology/diagnosis MH - *Health Knowledge, Attitudes, Practice MH - Young Adult MH - Hungary/epidemiology MH - Risk Factors MH - Surveys and Questionnaires MH - *Students/statistics & numerical data/psychology MH - Socioeconomic Disparities in Health MH - Schools MH - Mass Screening/methods MH - Socioeconomic Factors MH - Social Class PMC - PMC13119404 OTO - NOTNLM OT - FINDRISC OT - diabetes-related knowledge OT - health behavior OT - secondary school students OT - socioeconomic status OT - type 2 diabetes OT - young people COIS- The authors declare that they have no conflicts of interest. EDAT- 2026/05/04 06:32 MHDA- 2026/05/04 06:33 PMCR- 2026/04/18 CRDT- 2026/05/04 01:17 PHST- 2026/02/14 00:00 [received] PHST- 2026/04/13 00:00 [revised] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/05/04 06:33 [medline] PHST- 2026/05/04 06:32 [pubmed] PHST- 2026/05/04 01:17 [entrez] PHST- 2026/04/18 00:00 [pmc-release] AID - nu18081286 [pii] AID - nutrients-18-01286 [pii] AID - 10.3390/nu18081286 [doi] PST - epublish SO - Nutrients. 2026 Apr 18;18(8):1286. doi: 10.3390/nu18081286. PMID- 42075096 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 8 DP - 2026 Apr 18 TI - Children's Eating Behaviour Questionnaire Dimensions and Central Adiposity in Spanish Schoolchildren: Age-Stratified Associations. LID - 10.3390/nu18081283 [doi] LID - 1283 AB - Background/Objectives: Elevated central adiposity (ECA) in childhood is associated with early cardiometabolic risk and hemodynamic alterations. However, evidence in Spanish schoolchildren regarding the relationship between eating behavior traits and central adiposity is limited, particularly across developmental stages. This study aimed to examine the association between Children's Eating Behaviour Questionnaire (CEBQ) subscales and ECA, and to explore potential differences by age group. Methods: A cross-sectional study was conducted in 496 rural schoolchildren aged 6-15 years. ECA was defined using the waist-to-height ratio (WHtR) and sex-specific cut-offs validated for the Spanish pediatric population. Eating behavior was assessed with the CEBQ (Z-scores), and diet quality was measured using the KIDMED index. Multivariable logistic regression models were adjusted for sex, KIDMED score, and maternal education. Analyses were subsequently stratified by age (6-9 and 10-15 years). Results: The prevalence of ECA was 45.90%. In fully adjusted models, higher Food Responsiveness (FR) was associated with increased odds of ECA, while Satiety Responsiveness (SR) acted as a protective factor; sex also showed an independent association. After stratification, sex remained the only significant predictor in children aged 6-9 years. Among those aged 10-15 years, FR was significantly associated with ECA (p = 0.008), while Slowness in Eating (SE) showed a borderline positive association in the adjusted model (p = 0.049) and was therefore interpreted cautiously. SR and Emotional Undereating (EU) showed protective trends near significance (p = 0.081 and p = 0.082, respectively). Conclusions: The association between eating behavior traits and ECA varies by age. In older children, FR showed a robust association with ECA, whereas no behavioral predictors were observed in younger children. The protective role of SR in the global model and the emergence of behavioral predictors in older participants highlight the importance of targeted interventions during late childhood. FAU - Recio-Anon, Carlos AU - Recio-Anon C AUID- ORCID: 0009-0003-6511-6725 AD - Critical Care and Emergency Services Unit, Distrito Sanitario Cordoba Guadalquivir, 14011 Cordoba, Spain. AD - EPINUT Research Group (Ref. 929325), Complutense University of Madrid, 28037 Madrid, Spain. FAU - Lendinez-Jurado, Alfonso AU - Lendinez-Jurado A AUID- ORCID: 0000-0003-4408-1335 AD - UGC Churriana, Distrito Sanitario Malaga-Guadalhorce, 29009 Malaga, Spain. AD - Pediatric Gastroenterology Unit, Vithas Xanit International Hospital, 29630 Malaga, Spain. AD - Instituto de Investigacion Biomedica de Malaga (IBIMA)-Plataforma BIONAND, 29010 Malaga, Spain. FAU - Mata-Ordonez, Fernando AU - Mata-Ordonez F AUID- ORCID: 0000-0003-4126-577X AD - Department of Pharmacy and Nutrition, Faculty of Biomedical and Health Sciences, Universidad Europea de Madrid, 28670 Madrid, Spain. AD - Instituto Maimonides de Investigacion Biomedica de Cordoba (IMIBIC), Hospital Universitario Reina Sofia, 14004 Cordoba, Spain. FAU - Carracedo-Anon, Julia AU - Carracedo-Anon J AUID- ORCID: 0000-0002-8422-812X AD - Department of Genetics, Physiology and Microbiology, Faculty of Biological Sciences, Complutense University of Madrid, Health Research Institute Hospital 12 de Octubre (Imas12), 28041 Madrid, Spain. FAU - Gonzalez-Martin, Antonio AU - Gonzalez-Martin A AUID- ORCID: 0000-0003-0276-0778 AD - Department of Biodiversity, Ecology and Evolution, Faculty of Biological Sciences, Complutense University of Madrid, 28040 Madrid, Spain. FAU - Marrodan-Serrano, Maria Dolores AU - Marrodan-Serrano MD AUID- ORCID: 0000-0002-1697-1923 AD - EPINUT Research Group (Ref. 929325), Complutense University of Madrid, 28037 Madrid, Spain. AD - Department of Biodiversity, Ecology and Evolution, Faculty of Biological Sciences, Complutense University of Madrid, 28040 Madrid, Spain. LA - eng PT - Journal Article DEP - 20260418 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Spain/epidemiology MH - Adolescent MH - *Feeding Behavior MH - Cross-Sectional Studies MH - *Obesity, Abdominal/epidemiology MH - Surveys and Questionnaires MH - *Child Behavior MH - Age Factors MH - Adiposity MH - *Pediatric Obesity/epidemiology MH - Emotional Eating MH - Prevalence PMC - PMC13118514 OTO - NOTNLM OT - KIDMED OT - central adiposity OT - children's eating behaviour questionnaire OT - eating behavior OT - pediatrics OT - schoolchildren OT - waist-to-height ratio COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/18 CRDT- 2026/05/04 01:17 PHST- 2026/03/10 00:00 [received] PHST- 2026/04/10 00:00 [revised] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:17 [entrez] PHST- 2026/04/18 00:00 [pmc-release] AID - nu18081283 [pii] AID - nutrients-18-01283 [pii] AID - 10.3390/nu18081283 [doi] PST - epublish SO - Nutrients. 2026 Apr 18;18(8):1283. doi: 10.3390/nu18081283. PMID- 42075081 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 8 DP - 2026 Apr 17 TI - Water and Energy Turnover in Chinese Young Adults: A Doubly Labeled Water Study of Metabolic Coupling. LID - 10.3390/nu18081268 [doi] LID - 1268 AB - BACKGROUND: Accurate estimation of water and energy requirements is fundamental for establishing dietary reference values in young adults. However, evidence integrating objectively measured energy expenditure with detailed water turnover components remains limited in Chinese populations. OBJECTIVES: To quantify water intake, water loss, and energy expenditure in healthy young college students, and to examine how energy metabolism is associated with specific components of water turnover under free-living conditions. METHODS: Twenty-one healthy adults aged 18-25 years participated in a 14-day observational study conducted in Beijing, China. Total energy expenditure (TEE) was measured over 14 days using the doubly labeled water (DLW) method. Physical activity was monitored over 7 consecutive days using a triaxial accelerometer. Water intake was assessed using multiple methods: water from beverages (including plain drinking water and other beverages) was recorded over 7 days using 24 h fluid intake records, while water from food was measured during days 5-7 using weighed food records combined with duplicate portion and direct drying methods. Urinary and fecal water loss were quantified using 24 h collections conducted during days 5-7. Metabolic water production and insensible water losses were estimated using established physiological equations. Multivariable linear regression analyses were conducted to examine associations between energy-related variables and components of water turnover. RESULTS: Mean total daily water intake was 3023 mL, with water from beverages accounting for 54.1%, water from food for 36.7%, and metabolic water for 9.1%. Mean total daily water loss was 1931 mL, predominantly from urinary excretion (81.0%). DLW-measured TEE averaged 2018.6 kcal/day and was higher in males than in females. Most regression models examining total water intake and beverage-derived water were not statistically significant, and no consistent associations were observed between these variables and total energy intake, TEE, or PAEE. In contrast, TEE was positively associated with metabolic water production and respiratory water loss (both p < 0.001). Significant associations with total energy intake were observed for water from food and fecal water loss (both p < 0.01), whereas other water intake components showed no significant associations. CONCLUSIONS: In young adults, energy metabolism appears to be more closely associated with physiologically regulated components of water turnover than with voluntary water intake. These findings suggest a divergence between endogenous and behaviorally regulated pathways of water turnover and highlight the importance of considering component-specific water dynamics when examining hydration and energy balance, although confirmation in larger studies is warranted. FAU - Wang, Xing AU - Wang X AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China. AD - Clinical Nutrition Department, Ningbo Medical Center Li Huili Hospital, 1111 Jiangnan Road, Yinzhou District, Ningbo 315000, China. FAU - Qu, Chang AU - Qu C AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China. AD - Office of National Nutrition Plan, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing 100050, China. FAU - Zhang, Jianfen AU - Zhang J AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China. AD - Department of Student Nutrition, National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, 27 Nanwei Road, Xicheng District, Beijing 100050, China. FAU - Zhang, Na AU - Zhang N AUID- ORCID: 0000-0001-7713-5980 AD - Department of Nutrition and Food Hygiene, School of Public Health, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China. AD - Laboratory of Toxicological Research and Risk Assessment for Food Safety, Peking University, 38 Xue Yuan Road, Haidian District, Beijing 100191, China. LA - eng GR - Grant No. DIC2021-02/Danone Nutrition Center Dietary Nutrition Research and Education Fund/ PT - Journal Article PT - Observational Study DEP - 20260417 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 059QF0KO0R (Water) RN - Chinese people SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - Beverages MH - China MH - *Drinking/physiology MH - Energy Intake MH - *Energy Metabolism/physiology MH - Exercise MH - *Water/metabolism MH - East Asian People PMC - PMC13118442 OTO - NOTNLM OT - doubly labeled water OT - energy expenditure OT - water turnover OT - young adults COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/17 CRDT- 2026/05/04 01:17 PHST- 2026/02/25 00:00 [received] PHST- 2026/04/02 00:00 [revised] PHST- 2026/04/15 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:17 [entrez] PHST- 2026/04/17 00:00 [pmc-release] AID - nu18081268 [pii] AID - nutrients-18-01268 [pii] AID - 10.3390/nu18081268 [doi] PST - epublish SO - Nutrients. 2026 Apr 17;18(8):1268. doi: 10.3390/nu18081268. PMID- 42075045 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260818 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 8 DP - 2026 Apr 14 TI - Sex Differences in the Associations of Physical Activity and Planetary Health Diet with Obesity and Depressive Symptoms Among Adolescents in Zhejiang Province: An Observational Study. LID - 10.3390/nu18081232 [doi] LID - 1232 AB - Background: Adolescent obesity and depressive symptoms have increased concurrently, often presenting as co-occurrence. However, evidence on the timing of physical activity (e.g., weekday vs. weekend) and adherence to planetary health diets remains limited. This study examined these associations among adolescents in Zhejiang Province from 2022 to 2024. Methods: A total of 261,495 adolescents aged 11-18 years were included. Physical activity (PA) and dietary behaviors were assessed through the China Common Disease and Risk Factor Surveillance among Students questionnaire (reliability: Cronbach's alpha = 0.84, validity: RMSEA = 0.07). The plant-based Planetary Health Diet Index (PHDI-green) adherence was defined as consuming at least one daily serving of both vegetables and fruits. Depressive symptoms were measured using the Center for Epidemiologic Studies Depression (CES-D) scale, and co-occurrence was defined as the coexistence of obesity and depressive symptoms. Temporal trends were tested using chi(2) tests. Sex-stratified logistic regression, restricted cubic spline analyses, and population attributable fraction (PAF) analyses were applied. Results: From 2022 to 2024, obesity (p for trend = 0.013) and depressive symptoms (p for trend = 0.003) increased significantly, while co-occurrence remained stable (p for trend = 0.058). Boys had higher obesity and co-occurrence, whereas girls showed higher depressive symptoms (all p < 0.001). Higher weekly PA, greater weekend PA and PHDI-green adherence were associated with reduced odds of obesity in both sexes (all p < 0.001). Weekend PA showed stronger associations with depressive symptoms among girls, while PHDI-green showed stronger inverse associations in boys (p for sex difference < 0.001). PAF analyses suggested that low weekend PA accounted for substantial proportions of cases (girls: obesity 10.17%, depressive symptoms 31.30%, co-occurrence 35.64%). Joint adherence to adequate PA and PHDI-green conferred the lowest odds of co-occurrence (boys: OR = 0.40, 95% CI: 0.34-0.46; girls: OR = 0.33, 95% CI: 0.26-0.43). Conclusions: Adherence to the Planetary Health Diet may be particularly relevant for boys, whereas PA-especially weekend PA-may be more strongly associated with health outcomes among girls. These findings suggest the importance of sex-specific and time-targeted behavioral strategies for obesity, depressive symptoms, and their co-occurrence in adolescents. FAU - Lu, Qu AU - Lu Q AUID- ORCID: 0000-0001-8681-9233 AD - School of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. FAU - Chen, Manman AU - Chen M AD - School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. FAU - Wang, Jiahui AU - Wang J AD - School of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. FAU - Zhao, Yuankai AU - Zhao Y AUID- ORCID: 0009-0002-9102-857X AD - School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. FAU - Ye, Zichen AU - Ye Z AUID- ORCID: 0000-0003-0585-6687 AD - School of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. FAU - Hu, Jie AU - Hu J AUID- ORCID: 0000-0003-2940-6525 AD - School of Pharmacy and Medical Sciences, Griffith University, Nathan, Brisbane, QLD 4111, Australia. AD - Faculty of Medicine, The University of Queensland, St Lucia, Brisbane, QLD 4072, Australia. FAU - Meng, Jia AU - Meng J AD - Division of School Health, Department of Nutrition and Food Safety, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China. FAU - Li, Juanjuan AU - Li J AD - Division of School Health, Department of Nutrition and Food Safety, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China. FAU - Shen, Yu AU - Shen Y AUID- ORCID: 0000-0002-5984-8781 AD - Division of School Health, Department of Nutrition and Food Safety, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China. FAU - Gu, Fang AU - Gu F AUID- ORCID: 0000-0001-9163-0566 AD - Division of School Health, Department of Nutrition and Food Safety, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China. FAU - Jiang, Yu AU - Jiang Y AD - School of Health Policy and Management, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China. FAU - Dong, Bin AU - Dong B AUID- ORCID: 0000-0002-8123-4401 AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing 100871, China. LA - eng GR - 25&ZD252/the Major Projects of the National Social Science Fund of China/ GR - 7242187/the Beijing Natural Science Foundation/ GR - Grant No. 2023ZD0508500, 2023ZD0508505/the Chinese National Science and Technology Innovation 2030, Noncommunicable Chronic Dis-eases-National Science and Technology Major Project/ GR - 825B2103/the National Natural Science Foundation of China/ GR - 201920102401/the Research on the Construction of a New Public Health Science System and Talent Training Model/ PT - Journal Article PT - Observational Study DEP - 20260414 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adolescent MH - China/epidemiology MH - *Depression/epidemiology MH - Male MH - *Exercise MH - *Pediatric Obesity/epidemiology MH - Child MH - *Diet, Healthy/statistics & numerical data MH - Sex Factors PMC - PMC13118374 OTO - NOTNLM OT - adolescent OT - co-occurrence OT - physical activity OT - planetary health diet COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/14 CRDT- 2026/05/04 01:16 PHST- 2026/03/03 00:00 [received] PHST- 2026/04/11 00:00 [revised] PHST- 2026/04/13 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:16 [entrez] PHST- 2026/04/14 00:00 [pmc-release] AID - nu18081232 [pii] AID - nutrients-18-01232 [pii] AID - 10.3390/nu18081232 [doi] PST - epublish SO - Nutrients. 2026 Apr 14;18(8):1232. doi: 10.3390/nu18081232. PMID- 42075027 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 8 DP - 2026 Apr 11 TI - Chrononutrition, Body Composition, and Resting Metabolic Rate Among College Students: A Cross-Sectional Study. LID - 10.3390/nu18081214 [doi] LID - 1214 AB - BACKGROUND: Chrononutrition is essential for metabolic health, but relevant evidence in Chinese sports-majoring college students is still insufficient. This study aimed to identify chrononutrition patterns and their associations with body composition and resting metabolic rate (RMR) in college students from a sports university. METHODS: A cross-sectional study was conducted among 174 college students from Beijing Sport University (131 sports-majoring and 43 non-sports-majoring). Chrononutrition was measured by the validated Chinese version of the Chrononutrition Profile Questionnaire (CP-Q), body composition by dual-energy X-ray absorptiometry, and RMR by indirect calorimetry. Sample sizes varied across analyses according to data availability, and 133 participants provided valid data for both body composition and resting metabolic rate (RMR) assessments. RESULTS: Frequent night eating was positively correlated with BMI (r = 0.27, p = 0.001), and regular breakfast consumption was related to higher muscle mass percentage (beta = 0.23, p < 0.01, sr(2) = 0.05). Compared with non-sports-majoring students, sports-majoring students had longer weekday eating windows (11.2 +/- 2.8 h vs. 8.5 +/- 2.5 h, p < 0.001) and a higher dinner energy proportion (37.2 +/- 6.9% vs. 30.5 +/- 6.5%, p < 0.001). Males had later meal times and longer eating windows than females (breakfast: 7:58 vs. 7:46; dinner: 18:55 vs. 18:41; eating window: 11.5 h vs. 10.9 h; all p < 0.05). CONCLUSIONS: Chrononutrition was more closely associated with body composition than with absolute RMR in this predominantly sports-majoring sample of Chinese college students. Regular breakfast and reduced night eating are potential intervention targets for future chrononutrition guidance. However, the findings should be generalized to the broader college student population with caution. FAU - Xu, Kun AU - Xu K AD - Key Laboratory of the Ministry of Education of Exercise and Physical Fitness, School of Sport Science, Beijing Sport University, Beijing 100084, China. FAU - Yan, Shuo AU - Yan S AD - Key Laboratory of the Ministry of Education of Exercise and Physical Fitness, School of Sport Science, Beijing Sport University, Beijing 100084, China. FAU - Ji, Yuqin AU - Ji Y AD - Key Laboratory of the Ministry of Education of Exercise and Physical Fitness, School of Sport Science, Beijing Sport University, Beijing 100084, China. FAU - Meng, Yihan AU - Meng Y AD - Key Laboratory of the Ministry of Education of Exercise and Physical Fitness, School of Sport Science, Beijing Sport University, Beijing 100084, China. FAU - Li, Hongjuan AU - Li H AD - Key Laboratory of the Ministry of Education of Exercise and Physical Fitness, School of Sport Science, Beijing Sport University, Beijing 100084, China. LA - eng GR - 2023ZD0508500,2023ZD0508502/National Science and Technology Innovation 2030 Major Project "Major Special Project for Four Major Chronic Diseases"/ PT - Journal Article DEP - 20260411 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - *Basal Metabolism/physiology MH - *Body Composition/physiology MH - *Students/statistics & numerical data MH - Young Adult MH - Universities MH - *Feeding Behavior/physiology MH - Body Mass Index MH - Adolescent MH - Surveys and Questionnaires MH - Calorimetry, Indirect MH - Absorptiometry, Photon MH - Adult PMC - PMC13119362 OTO - NOTNLM OT - Chinese young adults OT - body composition OT - chrononutrition OT - resting metabolic rate OT - sports-majoring college students COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/11 CRDT- 2026/05/04 01:16 PHST- 2026/03/17 00:00 [received] PHST- 2026/04/09 00:00 [revised] PHST- 2026/04/10 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:16 [entrez] PHST- 2026/04/11 00:00 [pmc-release] AID - nu18081214 [pii] AID - nutrients-18-01214 [pii] AID - 10.3390/nu18081214 [doi] PST - epublish SO - Nutrients. 2026 Apr 11;18(8):1214. doi: 10.3390/nu18081214. PMID- 42075023 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 8 DP - 2026 Apr 11 TI - Conditions for Knowledge and Application of Vegetarian/Vegan Diets Among Secondary School Students: A Cross-Sectional Study. LID - 10.3390/nu18081210 [doi] LID - 1210 AB - Background/Objectives: Knowledge of plant-based diets is gaining increasing significance in adolescents due to the growing popularity of vegetarian and vegan dietary patterns. To date, there has been limited research examining the level of awareness and understanding of these diets among secondary school students, as well as the factors influencing their knowledge. The aim of the study was to determine the prevalence of plant-based diets and to assess knowledge regarding these dietary patterns among high school students, as well as to identify factors associated with both diet adherence and achieving sufficient nutritional knowledge. Methods: A cross-sectional study was conducted among 341 high school students. Data were collected using a self-administered paper questionnaire that included demographic information, self-reported body weight and height, adherence to plant-based diets, and knowledge of vegetarian and vegan nutrition. Nutritional knowledge was assessed using a structured 19-item questionnaire (25 scorable items) and verified for reliability (test-retest, Krippendorff's alpha = 0.88). Based on a 25-point scale, a score of >60% (16-25 points) was categorized as 'sufficient' knowledge. Statistical analyses included the chi-square test, Mann-Whitney and Kruskal-Wallis non-parametric tests, and multivariable logistic regression to estimate adjusted odds ratios (aOR) for factors associated with sufficient knowledge. Results: The prevalence of plant-based diets in the study group was 16.1% (n = 55), with a significantly higher frequency observed among female students and those with sufficient nutritional knowledge. The majority of students (81.2%) achieved sufficient knowledge. Higher scores were observed among female students, those in higher grade levels, and those individuals adhering to plant-based diets (p < 0.05). Multivariate regression analysis indicated that male sex (aOR = 0.38 compared to females), higher grade level (aOR = 3.66 for grade 3 vs. grade 1; aOR = 3.62 for grade 4 vs. grade 1), residence in a rural area (aOR = 0.50), and non-adherence to a plant-based diet (aOR = 0.32) were independently associated with sufficient knowledge. Conclusions: The majority of high school students demonstrate sufficient knowledge regarding plant-based diets, with significant variations associated with sex, grade level, place of residence, and experience with plant-based diets. These findings underscore the need for targeted educational interventions, particularly among male students, those in lower grade levels, and individuals residing in rural areas. FAU - Kurzawska, Oliwia AU - Kurzawska O AD - Department of Human Nutrition, Faculty of Biotechnology and Food Science, Wroclaw University of Environmental and Life Sciences, 37 Chelmonskiego Street, 51-630 Wroclaw, Poland. FAU - Raczkowska, Ewa AU - Raczkowska E AUID- ORCID: 0000-0003-4205-1351 AD - Department of Human Nutrition, Faculty of Biotechnology and Food Science, Wroclaw University of Environmental and Life Sciences, 37 Chelmonskiego Street, 51-630 Wroclaw, Poland. LA - eng GR - The APC is financed by Wroclaw University of Environmental and Life Sciences./Wroclaw University of Environmental and Life Sciences/ PT - Journal Article DEP - 20260411 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - *Diet, Vegetarian/psychology MH - Adolescent MH - *Health Knowledge, Attitudes, Practice MH - Male MH - *Students/psychology MH - *Diet, Vegan/psychology MH - Surveys and Questionnaires MH - Schools PMC - PMC13118344 OTO - NOTNLM OT - BMI OT - adolescents OT - nutritional knowledge OT - plant-based diet OT - vegan diet OT - vegetarian diet COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/11 CRDT- 2026/05/04 01:16 PHST- 2026/02/16 00:00 [received] PHST- 2026/04/04 00:00 [revised] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:16 [entrez] PHST- 2026/04/11 00:00 [pmc-release] AID - nu18081210 [pii] AID - nutrients-18-01210 [pii] AID - 10.3390/nu18081210 [doi] PST - epublish SO - Nutrients. 2026 Apr 11;18(8):1210. doi: 10.3390/nu18081210. PMID- 42075022 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260814 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 8 DP - 2026 Apr 11 TI - How to Teach Healthy Life-Style Efficiently in a Pediatric Outpatient Setting: Proposal of an Innovative Tridimensional Pyramid. LID - 10.3390/nu18081209 [doi] LID - 1209 AB - BACKGROUND: Childhood obesity is a major public health concern associated with adverse metabolic outcomes later in life. Despite increased awareness, unhealthy lifestyle behaviors-including suboptimal diet quality, physical inactivity, insufficient sleep, and unfavorable body composition-remain prevalent in pediatric populations. Effective, child-centered educational tools for early prevention are still limited. METHODS: We developed the Lifestyle Tridimensional Pyramid, an educational model integrating nutrition, physical activity, and sleep within a single, three-dimensional framework. The model also addresses body composition by emphasizing the balance between skeletal muscle and adipose tissue and the interdependence of lifestyle behaviors. This narrative review is supported by an umbrella review of 17 systematic reviews and meta-analyses published between 2010 and 2025, synthesizing evidence on lifestyle behaviors of pediatric obesity. RESULTS: High- to moderate-quality evidence indicates that adherence to Mediterranean-style dietary patterns, regular moderate-to-vigorous physical activity, adequate sleep duration, and a healthier body composition might prevent the development of obesity and improved cardiometabolic profiles in children and adolescents. The pyramid provides a structured, visually accessible tool to support lifestyle counseling in pediatric outpatient settings and is adaptable to school- and community-based health promotion. CONCLUSIONS: Although prospective validation studies are warranted, the Lifestyle Tridimensional Pyramid represents a practical, evidence-informed framework to support integrated lifestyle education and improve primary and secondary prevention of pediatric obesity. FAU - Mohn, Angelika Anna AU - Mohn AA AUID- ORCID: 0000-0002-6747-9306 AD - Departement of Pediatrics, University of Chieti, 65100 Chieti, Italy. AD - Clinical Research Center, "G.d'Annunzio" Foundation, University of Chieti, 65100 Chieti, Italy. FAU - Pietro, Giada Di AU - Pietro GD AD - Departement of Pediatrics, University of Chieti, 65100 Chieti, Italy. FAU - Maggitti, Alessandro AU - Maggitti A AD - Departement of Pediatrics, University of Chieti, 65100 Chieti, Italy. FAU - Trisi, Giulia AU - Trisi G AD - Departement of Pediatrics, University of Chieti, 65100 Chieti, Italy. FAU - Bucci, Ilaria AU - Bucci I AD - Departement of Pediatrics, University of Chieti, 65100 Chieti, Italy. FAU - Passarelli, Martina AU - Passarelli M AD - Departement of Pediatrics, University of Chieti, 65100 Chieti, Italy. FAU - Polidori, Nella AU - Polidori N AUID- ORCID: 0000-0001-7441-2655 AD - Departement of Pediatrics, University of Chieti, 65100 Chieti, Italy. FAU - Ludovico, Armando Di AU - Ludovico AD AUID- ORCID: 0000-0002-2644-1475 AD - Departement of Pediatrics, University of Chieti, 65100 Chieti, Italy. FAU - Chiarelli, Francesco AU - Chiarelli F AD - Departement of Pediatrics, University of Chieti, 65100 Chieti, Italy. AD - Clinical Research Center, "G.d'Annunzio" Foundation, University of Chieti, 65100 Chieti, Italy. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260411 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - *Healthy Lifestyle MH - Exercise MH - *Health Promotion/methods MH - *Pediatric Obesity/prevention & control MH - Sleep MH - Adolescent MH - Body Composition MH - Life Style MH - Health Behavior MH - Diet, Mediterranean PMC - PMC13119281 OTO - NOTNLM OT - Mediterranean diet OT - health promotion OT - lifestyle education OT - pediatric obesity OT - physical activity OT - sleep hygiene OT - tridimensional pyramid COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:32 MHDA- 2026/05/04 12:35 PMCR- 2026/04/11 CRDT- 2026/05/04 01:16 PHST- 2026/02/12 00:00 [received] PHST- 2026/04/05 00:00 [revised] PHST- 2026/04/08 00:00 [accepted] PHST- 2026/05/04 12:35 [medline] PHST- 2026/05/04 06:32 [pubmed] PHST- 2026/05/04 01:16 [entrez] PHST- 2026/04/11 00:00 [pmc-release] AID - nu18081209 [pii] AID - nutrients-18-01209 [pii] AID - 10.3390/nu18081209 [doi] PST - epublish SO - Nutrients. 2026 Apr 11;18(8):1209. doi: 10.3390/nu18081209. PMID- 42075002 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 8 DP - 2026 Apr 10 TI - Development and Validation of the Athlete Food Insecurity Scale (AFIS). LID - 10.3390/nu18081189 [doi] LID - 1189 AB - Background/Objective: Athletes' dietary needs are influenced by the physiological demands of their sport, so the impacts of disrupted food access may vary from those experienced by the general population. This study aimed to develop and validate the Athlete Food Insecurity Scale (AFIS), a sport-specific tool designed to measure food insecurity in athletes. Materials and Methods: The study included 500 young adult athletes from 18 different sports disciplines. The sample was divided for exploratory factor analysis (n = 300) and confirmatory factor analysis (n = 200). Standard procedures for scale development were followed, including content validity assessment, construct validity testing, convergent validity analysis, and reliability evaluation. Results: The final 23-item scale demonstrated a four-factor structure including performance changes, coping strategies, basic nutritional needs, and physical access restraints. Factor loadings ranged from 0.344 to 0.956, item-total correlations from 0.513 to 0.781, and Cronbach's alpha coefficients from 0.827 to 0.937. Confirmatory factor analysis supported the modified model with acceptable fit indices (chi(2)/df = 2.41, RMSEA = 0.080, TLI = 0.900, CFI = 0.910), and standardized factor loadings ranged from 0.53 to 0.89 (p < 0.05). Subscale scores differed significantly across Household Food Security Survey Module food security categories, supporting convergent validity. Conclusions: The AFIS demonstrates strong psychometric properties and may provide a sensitive tool for identifying and monitoring sport-specific food insecurity among athletes. FAU - Yildirim, Gonca AU - Yildirim G AUID- ORCID: 0000-0001-8856-7359 AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Turkiye. AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Toros University, 33140 Mersin, Turkiye. FAU - Sunbul, Onder AU - Sunbul O AD - Department of Measurement and Evaluation in Education, Faculty of Education, Mersin University, 33110 Mersin, Turkiye. FAU - Bas, Murat AU - Bas M AUID- ORCID: 0000-0002-0494-301X AD - Department of Nutrition and Dietetics, Graduate School of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Turkiye. AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Acibadem Mehmet Ali Aydinlar University, 34752 Istanbul, Turkiye. FAU - Cetiner, Ozlem AU - Cetiner O AUID- ORCID: 0000-0001-9872-416X AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Atilim University, 06830 Ankara, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20260410 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Athletes/psychology MH - Reproducibility of Results MH - *Food Insecurity MH - Female MH - Male MH - Young Adult MH - Factor Analysis, Statistical MH - Surveys and Questionnaires MH - Psychometrics MH - Food Supply MH - Adolescent PMC - PMC13118386 OTO - NOTNLM OT - athletes OT - food access OT - psychometrics OT - sports nutrition COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/10 CRDT- 2026/05/04 01:16 PHST- 2026/03/01 00:00 [received] PHST- 2026/04/07 00:00 [revised] PHST- 2026/04/08 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:16 [entrez] PHST- 2026/04/10 00:00 [pmc-release] AID - nu18081189 [pii] AID - nutrients-18-01189 [pii] AID - 10.3390/nu18081189 [doi] PST - epublish SO - Nutrients. 2026 Apr 10;18(8):1189. doi: 10.3390/nu18081189. PMID- 42074931 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260504 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 8 DP - 2026 Apr 20 TI - Caring for the 'Heads-Down Generation': Screen Time and Physical Health Complaints Among Adolescents in Poland. LID - 10.3390/jcm15083130 [doi] LID - 3130 AB - Background/Objectives: Digital media play an important role in the lives of contemporary adolescents. While associated with many benefits, they also pose risks to physical health related to prolonged screen time and non-ergonomic body posture. This study analyzed the frequency of self-reported physical complaints among Polish adolescents in relation to time spent on different screen-based activities. Methods: The study included 9083 students aged 13-17 who completed an online survey in March and April 2024 in schools located in western Poland (approximately 30% of the region's student population). Physical symptoms selected from the HBSC-SCL instrument were analyzed and supplemented with neck or shoulder pain and eye strain. Results: Longer screen time was associated with more frequent occurrence of all analyzed complaints. A 5-item index ranging from 0 to 20 points was proposed, including headache, neck or shoulder pain, eye strain, dizziness, and problems falling asleep (mean 6.56 +/- 5.15). The index showed reliability at the level of alpha = 0.744 and good model fit according to CFA (RMSEA = 0.025). In a multivariate linear regression model (R(2) = 0.153), after adjusting for age, gender, place of residence, and family affluence, the variability of this index was most strongly associated with time spent on social media (beta = 0.40) and browsing websites (beta = 0.30). Gender-specific models were also compared. Conclusions: The results confirm the co-occurrence of physical complaints during adolescence and a significant association between their severity and screen-based activities, particularly engagement in social media. FAU - Mazur, Joanna AU - Mazur J AUID- ORCID: 0000-0002-3937-7230 AD - Department of Humanization of Medicine and Sexology, Collegium Medicum, University of Zielona Gora, 65-046 Zielona Gora, Poland. FAU - Kozakiewicz, Alicja AU - Kozakiewicz A AUID- ORCID: 0000-0001-6490-2511 AD - Department of Humanization of Medicine and Sexology, Collegium Medicum, University of Zielona Gora, 65-046 Zielona Gora, Poland. FAU - Porwit, Katarzyna AU - Porwit K AUID- ORCID: 0000-0002-2924-1268 AD - Centre of Migration Research, University of Warsaw, 02-093 Warsaw, Poland. FAU - Kleszczewska, Dorota AU - Kleszczewska D AUID- ORCID: 0000-0001-7523-8628 AD - Departament of Health Sociology, Education and Medical Communication, Institute of Mother and Child, 01-211 Warsaw, Poland. FAU - Bialorudzki, Maciej AU - Bialorudzki M AD - Department of Biomedical Aspects of Development and Sexology, Faculty of Education, University of Warsaw, 00-561 Warsaw, Poland. FAU - Izdebski, Zbigniew AU - Izdebski Z AUID- ORCID: 0000-0003-0165-1860 AD - Department of Humanization of Medicine and Sexology, Collegium Medicum, University of Zielona Gora, 65-046 Zielona Gora, Poland. AD - Department of Biomedical Aspects of Development and Sexology, Faculty of Education, University of Warsaw, 00-561 Warsaw, Poland. LA - eng PT - Journal Article DEP - 20260420 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13117625 OTO - NOTNLM OT - HBSC OT - adolescents OT - eye strain OT - musculoskeletal pain OT - physical health complaints OT - screen time OT - sedentary behavior OT - social media COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/20 CRDT- 2026/05/04 01:16 PHST- 2026/03/13 00:00 [received] PHST- 2026/04/16 00:00 [revised] PHST- 2026/04/17 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:16 [entrez] PHST- 2026/04/20 00:00 [pmc-release] AID - jcm15083130 [pii] AID - jcm-15-03130 [pii] AID - 10.3390/jcm15083130 [doi] PST - epublish SO - J Clin Med. 2026 Apr 20;15(8):3130. doi: 10.3390/jcm15083130. PMID- 42074878 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260504 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 8 DP - 2026 Apr 17 TI - The First Selective Screening for Type 1 Diabetes in a Pediatric Population in Bulgaria. LID - 10.3390/jcm15083075 [doi] LID - 3075 AB - Background: Screening for presymptomatic type 1 diabetes (T1D) reduces the risk of diabetic ketoacidosis (DKA) and allows for early intervention with disease-modifying therapies. Despite the rising incidence of T1D in Bulgaria, screening initiatives remain limited. This pilot study aims to evaluate the feasibility of selective T1D screening in high-risk children and identify potential clinical associations with islet autoimmunity. Methods: The study targeted a recruitment of 250 children aged 0-18 years (200 with a relative with T1D and 50 without). Screening for islet autoantibodies (AABs), including glutamic acid decarboxylase (GADA), insulin (IAA), insulinoma-associated-2 (IA-2A), zinc transporter-8 (ZnT8A), and islet cell cytoplasmic autoantibodies (ICAs), was performed via chemiluminescence immunoassay (CLIA). Participants testing positive for one or more AABs were scheduled for longitudinal immunological and metabolic follow-up to evaluate the persistence of autoimmunity and disease progression. Results: Between October 2024 and February 2026, the pilot study recruited 210 participants (84% of the 250 target), including 160 children with a relative (target 200) and 50 without a family history of T1D (target 50). Within the high-risk group, seven children (4.4%) tested positive for a single autoantibody (3 GADA, 2 ZnT8A, 1 IA-2A, and 1 IAA), while no autoantibodies were detected in the group without a relative. No cases of multiple autoantibody positivity or stage 3 T1D were identified in either group. Furthermore, no statistically significant associations were observed between autoantibody positivity and secondary factors, including breastfeeding, allergic status, a high-glycemic diet, frequent illness, and personal history of autoimmune disease. Conclusions: The findings validate the feasibility of selective T1D screening in Bulgaria, driven by high public interest and successful recruitment across both high-risk and general population cohorts. While this exploratory study found no significant clinical correlations, it establishes a vital roadmap for larger, longitudinal research. Ultimately, this pilot framework provides a scalable model for implementing standardized early detection to reduce the burden of T1D on the national healthcare system. FAU - Yaneva, Natasha AU - Yaneva N AUID- ORCID: 0000-0002-4360-9022 AD - Clinic for Pediatric Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital "Prof. Ivan Mitev", 1606 Sofia, Bulgaria. AD - Department of Pediatrics, Medical Faculty, Medical University of Sofia, 1431 Sofia, Bulgaria. FAU - Petrova, Meri AU - Petrova M AD - Laboratory of Clinical Immunology, University Hospital St. Ivan Rilski, Department of Clinical Immunology, Medical Faculty, Medical University of Sofia, 1431 Sofia, Bulgaria. FAU - Yordanova, Adelina AU - Yordanova A AUID- ORCID: 0000-0003-1065-0405 AD - Laboratory of Clinical Immunology, University Hospital St. Ivan Rilski, Department of Clinical Immunology, Medical Faculty, Medical University of Sofia, 1431 Sofia, Bulgaria. FAU - Popov, Trifon AU - Popov T AUID- ORCID: 0009-0001-1818-275X AD - Clinic for Pediatric Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital "Prof. Ivan Mitev", 1606 Sofia, Bulgaria. FAU - Arshinkova, Margarita AU - Arshinkova M AD - Clinic for Pediatric Endocrinology, Diabetes and Metabolic Diseases, University Children's Hospital "Prof. Ivan Mitev", 1606 Sofia, Bulgaria. AD - Department of Pediatrics, Medical Faculty, Medical University of Sofia, 1431 Sofia, Bulgaria. FAU - Kyurkchiev, Dobroslav AU - Kyurkchiev D AD - Laboratory of Clinical Immunology, University Hospital St. Ivan Rilski, Department of Clinical Immunology, Medical Faculty, Medical University of Sofia, 1431 Sofia, Bulgaria. FAU - Kurteva, Ekaterina AU - Kurteva E AUID- ORCID: 0000-0003-1968-5962 AD - Laboratory of Clinical Immunology, University Hospital St. Ivan Rilski, Department of Clinical Immunology, Medical Faculty, Medical University of Sofia, 1431 Sofia, Bulgaria. LA - eng GR - BG-RRP-2.004-0004-C01/European Union-NextGenerationEU/ PT - Journal Article DEP - 20260417 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13116972 OTO - NOTNLM OT - Bulgaria OT - disease prevention OT - early diagnosis OT - islet autoimmunity OT - pediatric diabetes OT - pilot study OT - screening feasibility OT - type 1 diabetes COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/17 CRDT- 2026/05/04 01:16 PHST- 2026/03/18 00:00 [received] PHST- 2026/04/13 00:00 [revised] PHST- 2026/04/15 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:16 [entrez] PHST- 2026/04/17 00:00 [pmc-release] AID - jcm15083075 [pii] AID - jcm-15-03075 [pii] AID - 10.3390/jcm15083075 [doi] PST - epublish SO - J Clin Med. 2026 Apr 17;15(8):3075. doi: 10.3390/jcm15083075. PMID- 42074422 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 4 DP - 2026 Apr 11 TI - DEMETRA: An ACT-Based Virtual Coach to Support Healthier Lifestyles in Overweight Pregnant Women-Protocol for a Feasibility Pilot Study. LID - 10.3390/ijerph23040483 [doi] LID - 483 AB - During pregnancy, women are more inclined to modify their habits and lifestyle to find a new balance and promote well-being for themselves and the child-to-be. However, the availability of nutritional and psychological support is often limited by stigma, geographic barriers, and a lack of services. Digital health tools are emerging as possible solutions to cover these needs. This study explores the acceptability, feasibility, and user experience of Demetra, a virtual coach based on Acceptance and Commitment Therapy (ACT), designed to promote healthy lifestyles and mental well-being. Fifty pregnant women will be enrolled in the feasibility study of the intervention. It starts with an educational part on the foundations of healthy eating and suggestions about lifestyle habits, followed by a six-week psychoeducational module. Content is delivered through text, audio, and video formats. User experience and engagement will be measured through validated questionnaires and semi-structured interviews. Psychological well-being will be evaluated both before and after the program. The intervention is expected to be well-received, with high levels of satisfaction and engagement, leading to a greater awareness of healthy behaviors, improved psychological flexibility, and enhanced overall well-being. Demetra offers an accessible solution to support women through the transformative experience of motherhood with a multidisciplinary and innovative approach. FAU - Nicoletti, Anna Elena AU - Nicoletti AE AUID- ORCID: 0009-0000-4051-6341 AD - Digital Health Research, Centre for Digital Health & Wellbeing, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Trento, Italy. FAU - Purin, Barbara AU - Purin B AUID- ORCID: 0000-0003-1913-6998 AD - Digital Health Research, Centre for Digital Health & Wellbeing, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Trento, Italy. FAU - Rizzi, Silvia AU - Rizzi S AUID- ORCID: 0000-0002-8610-2432 AD - Digital Health Research, Centre for Digital Health & Wellbeing, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Trento, Italy. FAU - Dalmonego, Carlo AU - Dalmonego C AD - Digital Health Research, Centre for Digital Health & Wellbeing, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Trento, Italy. FAU - Bezzeccheri, Anna AU - Bezzeccheri A AD - Digital Health Research, Centre for Digital Health & Wellbeing, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Trento, Italy. FAU - Corradini, Silvia AU - Corradini S AD - Digital Health Research, Centre for Digital Health & Wellbeing, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Trento, Italy. FAU - Poggianella, Stefania AU - Poggianella S AUID- ORCID: 0000-0001-6271-6037 AD - Digital Health Research, Centre for Digital Health & Wellbeing, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Trento, Italy. FAU - Paoli, Claudia AU - Paoli C AUID- ORCID: 0009-0003-9668-5234 AD - Transmural Obstetric Gynecological Department, Healthcare Trust of the Autonomous Province of Trento (APSS), 38122 Trento, Italy. FAU - Burlon, Barbara AU - Burlon B AD - Transmural Obstetric Gynecological Department, Healthcare Trust of the Autonomous Province of Trento (APSS), 38122 Trento, Italy. FAU - Zorzi, Marina AU - Zorzi M AD - Transmural Obstetric Gynecological Department, Healthcare Trust of the Autonomous Province of Trento (APSS), 38122 Trento, Italy. FAU - Lazzari, Cecilia AU - Lazzari C AD - Transmural Obstetric Gynecological Department, Healthcare Trust of the Autonomous Province of Trento (APSS), 38122 Trento, Italy. FAU - Depaoli, Stefania AU - Depaoli S AD - Transmural Obstetric Gynecological Department, Healthcare Trust of the Autonomous Province of Trento (APSS), 38122 Trento, Italy. FAU - Fronza, Ornella AU - Fronza O AD - Transmural Obstetric Gynecological Department, Healthcare Trust of the Autonomous Province of Trento (APSS), 38122 Trento, Italy. FAU - Lorenzato, Enrica AU - Lorenzato E AD - Transmural Obstetric Gynecological Department, Healthcare Trust of the Autonomous Province of Trento (APSS), 38122 Trento, Italy. FAU - Marroni, Debora AU - Marroni D AD - Operating Unit of Psychology, Healthcare Trust of the Autonomous Province of Trento (APSS), 38122 Trento, Italy. FAU - Forti, Stefano AU - Forti S AD - Digital Health Research, Centre for Digital Health & Wellbeing, Fondazione Bruno Kessler, Via Sommarive 18, 38123 Trento, Italy. FAU - Taddei, Fabrizio AU - Taddei F AD - Transmural Obstetric Gynecological Department, Healthcare Trust of the Autonomous Province of Trento (APSS), 38122 Trento, Italy. LA - eng PT - Journal Article DEP - 20260411 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Pilot Projects MH - Feasibility Studies MH - *Overweight/therapy/psychology MH - *Healthy Lifestyle MH - *Health Promotion/methods MH - *Pregnant People MH - Adult PMC - PMC13116530 OTO - NOTNLM OT - ACT OT - digital intervention OT - eHealth OT - healthy eating OT - healthy lifestyles OT - mental well-being OT - overweight OT - pregnancy OT - usability OT - user-centred design COIS- Anna Elena Nicoletti was employed by Fondazione Bruno Kessler. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationship that could be construed as a potential conflict of interest. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/11 CRDT- 2026/05/04 01:14 PHST- 2025/07/15 00:00 [received] PHST- 2025/08/12 00:00 [revised] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:14 [entrez] PHST- 2026/04/11 00:00 [pmc-release] AID - ijerph23040483 [pii] AID - ijerph-23-00483 [pii] AID - 10.3390/ijerph23040483 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 Apr 11;23(4):483. doi: 10.3390/ijerph23040483. PMID- 42073428 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260504 LR - 20260813 IS - 2075-1729 (Print) IS - 2075-1729 (Electronic) IS - 2075-1729 (Linking) VI - 16 IP - 4 DP - 2026 Apr 7 TI - The Relationship Between Eating Habits and Anthropometric Values in High School Adolescents. LID - 10.3390/life16040618 [doi] LID - 618 AB - Objectives: The present study aimed to examine the relationship between dietary habits and anthropometric characteristics of high school adolescents. Participants and Methods: This cross-sectional study involved randomly selecting 104 students (34 boys and 70 girls) who were 17-19 years old. To evaluate dietary habits, a validated and standardized EPIC-Norfolk frequency food questionnaire was used, and anthropometric characteristics of the participants were assessed. Results: The most often consumed foods during the week were meats and fruits, while the least frequently consumed were fish and vegetables. For all participants, intake below the recommended levels was for alpha-carotene, total carbohydrate sugars, vitamin D, milk, dairy products, nuts, and seeds. Intake of proteins and iron was below the recommended levels in girls. Boys had a lower intake of proteins and fruits compared to girls. No differences were observed in the consumption of macronutrients. The median of all anthropometric values was within the reference values. Boys were slightly older and had significantly higher values of body weight and height, BMI, waist circumference, and waist-to-hip-ratio (WHR) compared to girls. In addition, systolic blood pressure (SBP) was significantly higher in males than in females. Participants with increased arterial blood pressure (ABP) showed significantly higher energy intake from fat, sodium intake, and total fat intake compared to those with normal ABP. Participants with increased WHR had significantly higher energy intake, intake of sodium, and total carbohydrates compared to those with normal WHR. Conclusions: This study shows that adolescents' eating habits (particularly intake of fat and sodium) were associated with anthropometric values, ABP, and WHR, which present risks for cardiometabolic diseases in adulthood. FAU - Firi, Lucija AU - Firi L AD - Health Centre Osijek-Baranja County, 31000 Osijek, Croatia. FAU - Mihaljevic, Dubravka AU - Mihaljevic D AUID- ORCID: 0000-0002-0051-4154 AD - Department of Nephrology, Clinical Hospital Centre Osijek, J. Huttlera 4, 31000 Osijek, Croatia. FAU - Prosic, Ivan AU - Prosic I AD - General Hospital Nasice, 31500 Nasice, Croatia. FAU - Kralik, Kristina AU - Kralik K AUID- ORCID: 0000-0002-4481-6365 AD - Department of Medical Statistics and Medical Informatics, Faculty of Medicine Osijek, University Josip Juraj Strossmayer Osijek, J. Huttlera 4, 31000 Osijek, Croatia. FAU - Stupin, Ana AU - Stupin A AUID- ORCID: 0000-0002-7446-0021 AD - Department of Physiology and Immunology, Faculty of Medicine Osijek, University Josip Juraj Strossmayer Osijek, J. Huttlera 4, 31000 Osijek, Croatia. FAU - Jukic, Ivana AU - Jukic I AUID- ORCID: 0000-0003-3795-2112 AD - Department of Physiology and Immunology, Faculty of Medicine Osijek, University Josip Juraj Strossmayer Osijek, J. Huttlera 4, 31000 Osijek, Croatia. FAU - Drenjancevic, Ines AU - Drenjancevic I AUID- ORCID: 0000-0003-4964-7721 AD - Department of Physiology and Immunology, Faculty of Medicine Osijek, University Josip Juraj Strossmayer Osijek, J. Huttlera 4, 31000 Osijek, Croatia. LA - eng GR - IP18-MEFOS_2024 and IP20-MEFOS-2025/Faculty of Medicine Osijek/ PT - Journal Article DEP - 20260407 PL - Switzerland TA - Life (Basel) JT - Life (Basel, Switzerland) JID - 101580444 PMC - PMC13117922 OTO - NOTNLM OT - anthropometry OT - body mass index OT - dietary habits OT - waist-hip ratio COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:32 MHDA- 2026/05/04 06:33 PMCR- 2026/04/07 CRDT- 2026/05/04 01:10 PHST- 2026/02/27 00:00 [received] PHST- 2026/03/15 00:00 [revised] PHST- 2026/04/03 00:00 [accepted] PHST- 2026/05/04 06:33 [medline] PHST- 2026/05/04 06:32 [pubmed] PHST- 2026/05/04 01:10 [entrez] PHST- 2026/04/07 00:00 [pmc-release] AID - life16040618 [pii] AID - life-16-00618 [pii] AID - 10.3390/life16040618 [doi] PST - epublish SO - Life (Basel). 2026 Apr 7;16(4):618. doi: 10.3390/life16040618. PMID- 42073157 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260504 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 4 DP - 2026 Apr 21 TI - Publication Bias in Epidemiological Studies of Malocclusions in Mexican Children and Teenagers: A Systematic Review and Meta-Analysis. LID - 10.3390/children13040580 [doi] LID - 580 AB - OBJECTIVE: To determine the publication bias of the reported prevalence of malocclusions in Mexican children and adolescents. BACKGROUND: Publication bias determination is crucial in a systematic review, helping to ensure the conclusions' validity and reliability. Nevertheless, without accurate knowledge of disease prevalence and patterns, the health system risks inefficiency, inequity, and failure to meet the population's needs. On the other hand, malocclusions can impair proper chewing efficiency, contributing to digestive alterations, and nutritional deficiencies among other functional, psychological, and social problems. The data of the prevalence of malocclusion is imperative to implement early interventions in health services that prevent more severe skeletal discrepancies and reduce the need for invasive treatments in adolescence or adulthood. METHODS: Studies were collected from five databases, following the PRISMA and Cochrane guidelines for systematic reviews. Eligibility criteria were full-text research in which the prevalence of malocclusions was reported. The risk of bias (Hoy tool), publication bias (the Doi plot and the Luis Furuya-Kanamori (LFK) index), and quality assessments (GRADE tool) were performed. The data were combined using a random-effects meta-analysis. RESULTS: The result of the meta-analysis suggests a high prevalence of malocclusions in mixed dentition was 50.2% (95% confidence interval [CI]: 38.9-61.5%). However, the studies showed a risk of bias and publication bias. CONCLUSIONS: In Mexico, there is a high prevalence of malocclusions among children and adolescents. However, these results are not robust enough to draw solid conclusions, due to the low certainty of the evidence. FAU - Argueta-Figueroa, Liliana AU - Argueta-Figueroa L AUID- ORCID: 0000-0002-1044-6757 AD - SECIHTI-Tecnologico Nacional de Mexico/Instituto Tecnologico de Toluca, Metepec 52149, Estado de Mexico, Mexico. FAU - Quiroz-Carlin, Karina Alejandra AU - Quiroz-Carlin KA AD - Laboratorio de Medicina Complementaria, Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontologia, Universidad Autonoma "Benito Juarez" de Oaxaca (UABJO), Universidad Avenue, "Ex-Hacienda de Cinco Senores", Oaxaca de Juarez 68120, Oaxaca, Mexico. AD - Departamento de Ortodoncia, Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontologia, Universidad Autonoma "Benito Juarez" de Oaxaca (UABJO), Universidad Avenue, "Ex-Hacienda de Cinco Senores", Oaxaca de Juarez 68120, Oaxaca, Mexico. FAU - Bautista-Hernandez, Mario Alberto AU - Bautista-Hernandez MA AD - Laboratorio de Medicina Complementaria, Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontologia, Universidad Autonoma "Benito Juarez" de Oaxaca (UABJO), Universidad Avenue, "Ex-Hacienda de Cinco Senores", Oaxaca de Juarez 68120, Oaxaca, Mexico. AD - Programa de Doctorado en Biociencias (SNP 005846), Facultad de Medicina y Cirugia, Universidad Autonoma "Benito Juarez" de Oaxaca (UABJO), Ex Hacienda de Aguilera S/N, Sur, San Felipe del Agua 68020, Oaxaca, Mexico. FAU - Torres-Rosas, Rafael AU - Torres-Rosas R AUID- ORCID: 0000-0002-5934-003X AD - Laboratorio de Medicina Complementaria, Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontologia, Universidad Autonoma "Benito Juarez" de Oaxaca (UABJO), Universidad Avenue, "Ex-Hacienda de Cinco Senores", Oaxaca de Juarez 68120, Oaxaca, Mexico. FAU - Castro-Gutierrez, Maria Eugenia Marcela AU - Castro-Gutierrez MEM AD - Laboratorio de Medicina Complementaria, Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontologia, Universidad Autonoma "Benito Juarez" de Oaxaca (UABJO), Universidad Avenue, "Ex-Hacienda de Cinco Senores", Oaxaca de Juarez 68120, Oaxaca, Mexico. FAU - Perez-Cervera, Yobana AU - Perez-Cervera Y AD - Laboratorio de Medicina Complementaria, Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontologia, Universidad Autonoma "Benito Juarez" de Oaxaca (UABJO), Universidad Avenue, "Ex-Hacienda de Cinco Senores", Oaxaca de Juarez 68120, Oaxaca, Mexico. FAU - Moreno-Rodriguez, Adriana AU - Moreno-Rodriguez A AD - Facultad de Ciencias Quimicas, Universidad Autonoma "Benito Juarez" de Oaxaca (UABJO), Oaxaca de Juarez 68120, Oaxaca, Mexico. FAU - Acevedo-Mascarua, Alfonso Enrique AU - Acevedo-Mascarua AE AD - Departamento de Ortodoncia, Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontologia, Universidad Autonoma "Benito Juarez" de Oaxaca (UABJO), Universidad Avenue, "Ex-Hacienda de Cinco Senores", Oaxaca de Juarez 68120, Oaxaca, Mexico. FAU - Martinez-Martinez, Enrique Antonio AU - Martinez-Martinez EA AD - Departamento de Ortodoncia, Centro de Estudios en Ciencias de la Salud y la Enfermedad, Facultad de Odontologia, Universidad Autonoma "Benito Juarez" de Oaxaca (UABJO), Universidad Avenue, "Ex-Hacienda de Cinco Senores", Oaxaca de Juarez 68120, Oaxaca, Mexico. LA - eng PT - Journal Article PT - Review DEP - 20260421 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13114715 OTO - NOTNLM OT - dentistry OT - epidemiological studies OT - malocclusions OT - orthodontic OT - prevalence OT - risk of bias COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:32 MHDA- 2026/05/04 06:33 PMCR- 2026/04/21 CRDT- 2026/05/04 01:09 PHST- 2026/02/16 00:00 [received] PHST- 2026/04/11 00:00 [revised] PHST- 2026/04/17 00:00 [accepted] PHST- 2026/05/04 06:33 [medline] PHST- 2026/05/04 06:32 [pubmed] PHST- 2026/05/04 01:09 [entrez] PHST- 2026/04/21 00:00 [pmc-release] AID - children13040580 [pii] AID - children-13-00580 [pii] AID - 10.3390/children13040580 [doi] PST - epublish SO - Children (Basel). 2026 Apr 21;13(4):580. doi: 10.3390/children13040580. PMID- 42073139 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260504 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 4 DP - 2026 Apr 18 TI - Models for Training in Pediatric Otologic Surgery: A Systematic Review. LID - 10.3390/children13040562 [doi] LID - 562 AB - Background/Objectives: Temporal bone surgery in children is technically challenging due to their smaller anatomical structures, developmental differences, and the closer proximity of critical neurovascular structures. The limited availability of conventional training materials and pediatric cadaveric specimens has led to greater enthusiasm for simulation-based methods. The aim of this systematic review was to identify existing otologic simulation models and evaluate their anatomical accuracy, teaching effectiveness, and supporting evidence. Methods: In accordance with PRISMA guidelines, the PubMed, Embase, Scopus, and Cochrane Library databases were searched for studies reporting simulation tools for pediatric otologic surgery. Articles describing three-dimensional printed (3DP) models, virtual reality (VR) platforms, cadaver specimens, and animal models were included. Studies focusing on children and providing educational outcomes were selected. The extracted data were synthetized and analytically discussed. Results: Thirteen studies met the inclusion criteria: nine on 3DP models and four on VR environments. No research involving cadavers or animals was identified. 3DP models exhibited consistent anatomical accuracy and notable educational advantages. Five studies used surveys for their evaluations, and three relied on expert observer assessments. The studies including validation analyses showed a high correlation between printed models and computed tomography (CT) images. VR systems supported anatomical reconstruction and segmentation tasks, as well as guided simulation exercises. However, most of the research consisted of feasibility studies with limited participant groups. Conclusions: Simulation-based training with 3DP and VR models could be ethical and accurate methods for obtaining relevant skills in pediatric otologic surgery. The reviewed data suggest that these tools may be suitable as a first-line step within an integrated, multimodal training pathway prior to direct patient contact. FAU - Carlotto, Elena AU - Carlotto E AUID- ORCID: 0000-0001-6971-4165 AD - Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy. AD - Department of Otorhinolaryngology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy. FAU - Cirillo, Serena AU - Cirillo S AUID- ORCID: 0009-0009-7949-0850 AD - Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy. AD - Department of Otorhinolaryngology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy. FAU - Marconi, Stefania AU - Marconi S AUID- ORCID: 0000-0003-4608-6180 AD - Department of Civil Engineering and Architecture, University of Pavia, 27100 Pavia, Italy. FAU - Pisani, Silvia AU - Pisani S AUID- ORCID: 0000-0002-5396-1601 AD - Department of Drug Sciences, University of Pavia, 27100 Pavia, Italy. FAU - Bertozzi, Mirko AU - Bertozzi M AUID- ORCID: 0000-0001-8669-8291 AD - Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy. AD - Pediatric Surgery Unit, Fondazione IRCCS Policlinico San Matteo, 27100 Pavia, Italy. FAU - Chiapperini, Cesare AU - Chiapperini C AUID- ORCID: 0009-0009-5807-9165 AD - Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy. AD - Department of Otorhinolaryngology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy. FAU - Mauramati, Simone AU - Mauramati S AD - Department of Otorhinolaryngology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy. FAU - Benazzo, Marco AU - Benazzo M AD - Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy. AD - Department of Otorhinolaryngology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy. FAU - Canzi, Pietro AU - Canzi P AD - Department of Clinical, Surgical, Diagnostic and Pediatric Sciences, University of Pavia, 27100 Pavia, Italy. AD - Department of Otorhinolaryngology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, 27100 Pavia, Italy. LA - eng PT - Journal Article PT - Review DEP - 20260418 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13114958 OTO - NOTNLM OT - 3D printing OT - pediatric otology OT - surgical simulation OT - surgical training OT - temporal bone OT - virtual reality OT - virtual reality surgical simulation COIS- The authors declare no conflict of interest. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/18 CRDT- 2026/05/04 01:09 PHST- 2026/03/18 00:00 [received] PHST- 2026/04/14 00:00 [revised] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:09 [entrez] PHST- 2026/04/18 00:00 [pmc-release] AID - children13040562 [pii] AID - children-13-00562 [pii] AID - 10.3390/children13040562 [doi] PST - epublish SO - Children (Basel). 2026 Apr 18;13(4):562. doi: 10.3390/children13040562. PMID- 42073123 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260504 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 4 DP - 2026 Apr 14 TI - Predictors of Response to Growth Hormone Therapy in Children with Idiopathic Growth Hormone Deficiency: A Narrative Review. LID - 10.3390/children13040545 [doi] LID - 545 AB - Background: Growth hormone deficiency (GHD) in childhood impairs linear growth and may affect body composition, metabolism, and quality of life; recombinant human growth hormone (rhGH) therapy improves outcomes, but response is highly variable, especially in idiopathic GHD (IGHD). Objective: To summarize current evidence on predictors of growth response to rhGH therapy in children with IGHD, focusing on clinical, biochemical, and treatment-related determinants. Methods: This is a narrative review dealing with studies assessing clinical, auxological, biochemical and treatment-associated factors that may influence response to rhGH in IGHD. Results: Early treatment initiation, baseline short stature, prepubertal status, and higher early height growth velocity are strong clinical predictors; biochemical markers, including GH peak, IGF-1, and IGFBP-3, provide complementary information. Modifiable factors such as GH dose, adherence to therapy, and therapy duration also influence outcomes. Integrated predictive models improve accuracy but require further validation. Conclusions: Growth response to rhGH in IGHD is multifactorial and could be individualized: early identification of suboptimal responders and personalized treatment strategies that integrate clinical, biochemical, and treatment-related data may optimize the final outcome. Future research studies should focus on validated predictive models incorporating genetic and molecular markers. FAU - Cammisa, Ignazio AU - Cammisa I AUID- ORCID: 0000-0002-8591-0964 AD - Department of Pediatrics, San Giovanni Evangelista Hospital, 00019 Tivoli, Italy. FAU - De Fortuna, Giulia AU - De Fortuna G AD - Department of Life Sciences and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy. FAU - Rulli, Eleonora AU - Rulli E AUID- ORCID: 0009-0004-0138-3792 AD - Department of Life Sciences and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy. FAU - Rigante, Donato AU - Rigante D AUID- ORCID: 0000-0001-7032-7779 AD - Department of Life Sciences and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy. AD - Department of Pediatrics, Universita Cattolica Sacro Cuore, 00168 Rome, Italy. FAU - Cipolla, Clelia AU - Cipolla C AD - Department of Life Sciences and Public Health, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, 00168 Rome, Italy. LA - eng PT - Journal Article PT - Review DEP - 20260414 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13114359 OTO - NOTNLM OT - bioinnovative therapies OT - childhood OT - growth OT - growth hormone deficiency OT - growth hormone therapy OT - personalized medicine COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/14 CRDT- 2026/05/04 01:09 PHST- 2026/03/15 00:00 [received] PHST- 2026/04/08 00:00 [revised] PHST- 2026/04/10 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:09 [entrez] PHST- 2026/04/14 00:00 [pmc-release] AID - children13040545 [pii] AID - children-13-00545 [pii] AID - 10.3390/children13040545 [doi] PST - epublish SO - Children (Basel). 2026 Apr 14;13(4):545. doi: 10.3390/children13040545. PMID- 42073091 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260504 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 4 DP - 2026 Apr 7 TI - Clinical Patterns and Outcomes of Eosinophilic Esophagitis in Children and Adolescents at a Tertiary Care Center in Lebanon. LID - 10.3390/children13040513 [doi] LID - 513 AB - BACKGROUND: Studies on the clinical presentation of eosinophilic esophagitis and its outcome in children in the Middle East and North African region are scarce. The aim of this 10-year retrospective study was to describe the common clinical manifestations, endoscopic and histological findings, and the response to medication and dietary intervention in children and adolescents with eosinophilic esophagitis. METHODS: This study was a retrospective chart review of patients aged 6 months to 18 years who attended the Pediatric Gastroenterology clinic at the American University of Beirut Medical Center between 1 January 2013 and 30 June 2023 and who were diagnosed with eosinophilic esophagitis. RESULTS: A total of 15 patients met the inclusion criteria. The median age at diagnosis was 9 years. Male patients accounted for 73% of our cohort. The most frequent presenting symptoms were dysphagia (80%) and choking (47%). The esophagus appeared normal in 33% of subjects despite histologic confirmation of disease, highlighting the importance of routine biopsies. Adherence to therapy was variable, with 73% of subjects reporting symptom improvement following initial therapy, even in cases where histology remained active. This pattern suggests that symptomatic improvement alone may not reliably reflect disease control and underscores the importance of objective monitoring through follow-up biopsy. CONCLUSIONS: The recognition of manifestations of eosinophilic esophagitis in children, early diagnosis, and strict adherence to the diet and medication are essential to prevent long-term complications. In a resource-constrained country like Lebanon, the management remains challenging in view of the burden of dietary restrictions and high cost of procedures and biologics. Socioeconomic feasibility and long-term adherence to diet and medication is as critical as pharmacologic efficacy in determining outcomes in pediatric patients. FAU - Rahi, Amal AU - Rahi A AD - Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut 1107, Lebanon. FAU - Hanna-Wakim, Rima AU - Hanna-Wakim R AD - Division of Pediatric Infectious Diseases, Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut 1107, Lebanon. FAU - Barhoumi, Abir AU - Barhoumi A AD - Department of Nutrition, American University of Beirut, Beirut 1107, Lebanon. FAU - Yazbeck, Nadine AU - Yazbeck N AUID- ORCID: 0000-0002-2325-4113 AD - Division of Pediatric Gastroenterology, Department of Pediatrics and Adolescent Medicine, American University of Beirut, Beirut 1107, Lebanon. LA - eng PT - Journal Article DEP - 20260407 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13114333 OTO - NOTNLM OT - children OT - diet OT - eosinophilic esophagitis OT - outcome OT - retrospective study COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:33 MHDA- 2026/05/04 06:34 PMCR- 2026/04/07 CRDT- 2026/05/04 01:09 PHST- 2026/02/26 00:00 [received] PHST- 2026/03/24 00:00 [revised] PHST- 2026/04/06 00:00 [accepted] PHST- 2026/05/04 06:34 [medline] PHST- 2026/05/04 06:33 [pubmed] PHST- 2026/05/04 01:09 [entrez] PHST- 2026/04/07 00:00 [pmc-release] AID - children13040513 [pii] AID - children-13-00513 [pii] AID - 10.3390/children13040513 [doi] PST - epublish SO - Children (Basel). 2026 Apr 7;13(4):513. doi: 10.3390/children13040513. PMID- 42073063 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260504 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 4 DP - 2026 Mar 31 TI - One-Year Follow-Up of Weight Trajectories After the EDDY School-Based Nutrition and Physical Activity Program. LID - 10.3390/children13040485 [doi] LID - 485 AB - Background/Objectives: The Effect of Diet and Exercise Training on Obesity and Secondary Disease Prevention and on the Lifestyle of Young Children (EDDY) study implemented a two-year school-based nutrition and physical activity program in a Viennese primary school to promote healthy weight trajectories. This follow-up examined whether anthropometric benefits persisted one year after program cessation without active intervention. Methods: Prospective longitudinal data from 36 intervention-group children (76.6% completion rate from baseline n = 47) were analyzed. Standardized measurements at baseline (T1), post-intervention (T2), and one-year post-intervention (T3) included BMI, SDS-BMI, and waist-to-height ratio by trained staff. Mixed-effects models evaluated changes over time with time, sex, baseline age, and baseline anthropometry as fixed effects. Results: At T3, median age was 10.5 years (IQR: 10.2-11.0). BMI increased consistently with normal growth (time effect p = 0.112), with a mean post-intervention increase of 0.70 kg/m(2) (95% CI: 0.41-0.99; p < 0.001). SDS-BMI remained stable across periods (time effect p = 0.967; post-intervention change +0.013 SDS units, 95% CI: -0.178 to 0.109; p = 0.826). Waist-to-height ratio showed small changes (time effect p = 0.041) modified by baseline values, remaining within normal range. No sex-by-time interactions were observed (all p > 0.13). Conclusions: One year post-EDDY intervention, participating children maintained stable SDS-BMI and waist-to-height trajectories, reflecting sustained healthy growth. These results highlight the feasibility of maintaining healthy weight trajectories after the EDDY school-based nutrition and physical activity program and underscore the need for larger controlled trials to establish the long-term effectiveness of school-based programs. FAU - Moliterno, Paula AU - Moliterno P AD - Austrian Academic Institute for Clinical Nutrition, 1090 Vienna, Austria. FAU - Widhalm, Kurt AU - Widhalm K AUID- ORCID: 0000-0001-8700-5573 AD - Austrian Academic Institute for Clinical Nutrition, 1090 Vienna, Austria. AD - Division of Clinical Nutrition and Prevention, Department of Pediatrics, Medical University of Vienna, 1090 Vienna, Austria. LA - eng GR - Geschaftszahl: 2022-0.813.540/Federal Ministry of Education, Science and Research, Austria (2022-2024)./ PT - Journal Article DEP - 20260331 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC13115548 OTO - NOTNLM OT - BMI OT - longitudinal follow-up OT - school-based intervention COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/05/04 06:32 MHDA- 2026/05/04 06:33 PMCR- 2026/03/31 CRDT- 2026/05/04 01:09 PHST- 2026/02/25 00:00 [received] PHST- 2026/03/26 00:00 [revised] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/05/04 06:33 [medline] PHST- 2026/05/04 06:32 [pubmed] PHST- 2026/05/04 01:09 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - children13040485 [pii] AID - children-13-00485 [pii] AID - 10.3390/children13040485 [doi] PST - epublish SO - Children (Basel). 2026 Mar 31;13(4):485. doi: 10.3390/children13040485. PMID- 42072787 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260504 LR - 20260813 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 16 IP - 8 DP - 2026 Apr 14 TI - Physical Activity Patterns and Cardiometabolic Risk in Children and Adolescents with Obesity: A Cross-Sectional Study. LID - 10.3390/diagnostics16081162 [doi] LID - 1162 AB - Introduction: Childhood and adolescent obesity is a growing global health challenge associated with early metabolic and cardiovascular complications. This study aims to compare questionnaire-assessed physical activity patterns and lifestyle characteristics among children and adolescents with obesity and normal-weight peers and to explore their associations with clinical measurements and cardiometabolic risk. Assessing resting metabolic rate (RMR) by indirect calorimetry may provide additional insight into metabolic status beyond conventional anthropometric indicators. Methods: This prospective cross-sectional study included 58 children and adolescents aged 5-18 years with obesity and 30 normal-weight controls evaluated in Sfanta Maria Emergency Children's Hospital Iasi, Romania. Clinical data included anthropometric measurements and available biochemical parameters. RMR was assessed through indirect calorimetry (Fitmate Pro, Cosmed, Rome, Italy). Parents completed a structured lifestyle questionnaire adapted from validated international instruments, collecting information on physical activity, sedentary behavior, and wearable device use. Data analysis was conducted using SPSS 22.0, applying descriptive statistics and Pearson correlation analysis. Results: Children with obesity reported higher body mass index (BMI) (30.48 +/- 5.31 kg/m(2)), higher RMR values, lower physical activity levels and greater sedentary time than controls. RMR correlated positively with BMI, central adiposity, blood pressure, waist-to-height, hepatic steatosis and exercise tolerance. Although electronic devices for monitoring physical activity were more frequently used in the obesity group, this was not associated with higher activity levels. Conclusions: Children and adolescents with obesity exhibited a clustered cardiometabolic risk profile and reduced physical activity. RMR measured by indirect calorimetry may contribute to a more comprehensive metabolic assessment in pediatric obesity. FAU - Manole, Lorena Mihaela AU - Manole LM AUID- ORCID: 0009-0003-6798-9984 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. FAU - Tarca, Elena AU - Tarca E AUID- ORCID: 0000-0002-3018-8011 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Sfanta Maria Emergency Children Hospital, 700309 Iasi, Romania. FAU - Spoiala, Elena-Lia AU - Spoiala EL AUID- ORCID: 0000-0002-7015-0085 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Sfanta Maria Emergency Children Hospital, 700309 Iasi, Romania. FAU - Boca, Laura Otilia AU - Boca LO AUID- ORCID: 0009-0007-1062-9995 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Sfanta Maria Emergency Children Hospital, 700309 Iasi, Romania. FAU - Donos, Madalina Andreea AU - Donos MA AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Sfanta Maria Emergency Children Hospital, 700309 Iasi, Romania. FAU - Paduraru, Gabriela AU - Paduraru G AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Sfanta Maria Emergency Children Hospital, 700309 Iasi, Romania. FAU - Ghiga, Gabriela AU - Ghiga G AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Sfanta Maria Emergency Children Hospital, 700309 Iasi, Romania. FAU - Tarca, Viorel AU - Tarca V AD - Faculty of Medicine, Apollonia University, 700511 Iasi, Romania. FAU - Pinzariu, Alin Constantin AU - Pinzariu AC AUID- ORCID: 0000-0001-5730-1662 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. FAU - Trandafir, Laura Mihaela AU - Trandafir LM AUID- ORCID: 0000-0002-8326-7610 AD - Grigore T. Popa University of Medicine and Pharmacy, 700115 Iasi, Romania. AD - Sfanta Maria Emergency Children Hospital, 700309 Iasi, Romania. LA - eng PT - Journal Article DEP - 20260414 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC13115053 OTO - NOTNLM OT - adolescent OT - cardiometabolic risk OT - child OT - digital health OT - obesity OT - physical activity OT - sedentary behavior OT - wearable devices COIS- The authors declare no conflicts of interest. EDAT- 2026/05/04 06:32 MHDA- 2026/05/04 06:33 PMCR- 2026/04/14 CRDT- 2026/05/04 01:08 PHST- 2026/03/08 00:00 [received] PHST- 2026/04/04 00:00 [revised] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/05/04 06:33 [medline] PHST- 2026/05/04 06:32 [pubmed] PHST- 2026/05/04 01:08 [entrez] PHST- 2026/04/14 00:00 [pmc-release] AID - diagnostics16081162 [pii] AID - diagnostics-16-01162 [pii] AID - 10.3390/diagnostics16081162 [doi] PST - epublish SO - Diagnostics (Basel). 2026 Apr 14;16(8):1162. doi: 10.3390/diagnostics16081162. PMID- 42071293 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1365-277X (Electronic) IS - 0952-3871 (Linking) VI - 39 IP - 3 DP - 2026 Jun TI - A Systems-Focused Exploration of the Perspectives of School Nutrition Directors on Integrating Frozen Fruit Smoothies Into School Meals. PG - e70262 LID - 10.1111/jhn.70262 [doi] AB - INTRODUCTION: This qualitative study explored school nutrition directors' perspectives on the feasibility, alignment, and sustainability of integrating a frozen fruit smoothie program into the National School Lunch Program (NSLP). Directors were viewed as system-level actors who operate within interconnected organizational, policy, and environmental structures that shape program implementation. METHODS: Semi-structured interviews were conducted with five school nutrition directors as part of the process evaluation of a pilot program titled HEALTHY (Helping Early Adolescents Live Their Healthiest Youth), which features smoothie tastings with integrated nutrition education. Interviews were transcribed and analyzed by three independent coders using inductive thematic analysis that considered patterns across individual, organizational, and policy systems. RESULTS: Nutrition directors described smoothies as feasible, aligned with NSLP requirements, and reported strong student preference: "Kids that might not eat whole fruit [...], but maybe they'll drink the whole smoothie." They also identified system-level barriers related to staffing, equipment, funding, and time that limit the implementation of smoothies. Finally, directors described the importance of standardized recipes, tools, and external partnerships. CONCLUSION: Findings highlight frozen fruit smoothies as a promising systems-focused strategy to support fruit intake among adolescents. Insights will guide the development of a scalable implementation toolkit to support the sustainable integration of smoothies into the NSLP. CI - (c) 2026 British Dietetic Association. FAU - Sullivan, Amelia AU - Sullivan A AUID- ORCID: 0009-0003-9729-5721 AD - School of Food and Agriculture, University of Maine, Orono, Maine, USA. FAU - Watras, Emma AU - Watras E AUID- ORCID: 0009-0003-4161-0024 AD - School of Food and Agriculture, University of Maine, Orono, Maine, USA. FAU - Kubinsky, Bryn AU - Kubinsky B AD - School of Food and Agriculture, University of Maine, Orono, Maine, USA. FAU - Mackay-Morgan, Christian AU - Mackay-Morgan C AD - School of Food and Agriculture, University of Maine, Orono, Maine, USA. FAU - McNamara, Jade AU - McNamara J AD - School of Food and Agriculture, University of Maine, Orono, Maine, USA. LA - eng GR - Wyman's Wild Blueberry Research & Innovation/ PT - Journal Article PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Humans MH - *Fruit MH - *Food Services/organization & administration MH - *Schools MH - Lunch MH - Qualitative Research MH - Adolescent MH - *Frozen Foods MH - Nutrition Policy MH - Pilot Projects MH - Female MH - Program Evaluation OTO - NOTNLM OT - National School Lunch Program (NSLP) OT - adolescent nutrition OT - behavior change OT - frozen fruit OT - school nutrition directors OT - smoothies OT - systems thinking EDAT- 2026/05/04 06:32 MHDA- 2026/05/04 06:33 CRDT- 2026/05/04 00:22 PHST- 2026/04/16 00:00 [revised] PHST- 2025/12/05 00:00 [received] PHST- 2026/04/24 00:00 [accepted] PHST- 2026/05/04 06:33 [medline] PHST- 2026/05/04 06:32 [pubmed] PHST- 2026/05/04 00:22 [entrez] AID - 10.1111/jhn.70262 [doi] PST - ppublish SO - J Hum Nutr Diet. 2026 Jun;39(3):e70262. doi: 10.1111/jhn.70262. PMID- 42071193 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 May 4 TI - Assessment of albumin-related inflammatory indices in preeclampsia and their relationship with composite adverse perinatal outcomes. LID - 10.1186/s12884-026-09208-9 [doi] LID - 670 AB - BACKGROUND: Preeclampsia is characterized by systemic inflammation, endothelial dysfunction, and multi-organ involvement, contributing to increased risk of adverse perinatal outcomes. Albumin-based inflammatory and nutritional indices have recently gained interest as easily accessible biomarkers in high-risk pregnancies. This study aimed to compare albumin-related indices between preeclamptic and normotensive pregnancies and to evaluate their predictive value for composite adverse perinatal outcomes (CAPO) in preeclampsia. METHODS: This retrospective case-control study included 186 preeclamptic patients and 186 healthy controls matched for maternal age, BMI, gravidity, and gestational age. Laboratory parameters measured at delivery and calculated indices (NAR, FAR, sACR, HALP, and BAR) were compared. The preeclampsia cohort was further classified into CAPO (+) and CAPO (-) groups. Logistic regression models were used to identify independent predictors of CAPO, and receiver operating characteristic (ROC) analysis assessed predictive performance. RESULTS: Albumin-based indices differed significantly between preeclamptic and healthy pregnancies, with higher NAR, FAR, and BAR values and lower sACR levels in the preeclampsia group (all p < 0.001). Among preeclamptic patients, CAPO developed in 44.1% (n = 82). CAPO (+) patients demonstrated higher NAR, BAR, and HALP values and lower sACR levels compared to CAPO (-) patients. In multivariable logistic regression, only the blood urea nitrogen-to-albumin ratio (BAR) remained independently associated with CAPO (aOR = 1.157, p = 0.015). BAR demonstrated moderate discriminative performance for CAPO (AUC = 0.718; cut-off > 0.61; sensitivity 67.1%; specificity 69.2%; p < 0.001). CONCLUSION: All albumin-based indices showed significant alterations in preeclampsia; however, only BAR independently predicted adverse perinatal outcomes. BAR is a simple, inexpensive biomarker derived from routine laboratory parameters and may support risk stratification and neonatal outcome prediction in preeclamptic pregnancies. Prospective multicenter studies are warranted to validate its clinical applicability. CI - (c) 2026. The Author(s). FAU - Kindan, Aykut AU - Kindan A AUID- ORCID: 0000-0002-0962-1036 AD - Department of Obstetrics and Gynecology, Nurdagi State Hospital, Gaziantep, Turkey. aykutkindan33@hotmail.com. FAU - Kindan, Goncagul AU - Kindan G AUID- ORCID: 0009-0001-7547-4695 AD - Department of Obstetrics and Gynecology, Ataturk Sanatoryum Training and Research Hospital, Ankara, Turkey. FAU - Kurt, Dilara Sarikaya AU - Kurt DS AUID- ORCID: 0000-0002-1492-0305 AD - Department of Obstetrics and Gynecology, Mudanya State Hospital, Bursa, Turkey. FAU - Cakir, Ayberk AU - Cakir A AUID- ORCID: 0000-0001-5749-4556 AD - Department of Obstetrics and Gynecology, Acibadem University Atakent Hospital, Istanbul, Turkey. FAU - Akbulut, Ozgur Volkan AU - Akbulut OV AUID- ORCID: 0000-0002-1960-2146 AD - Department of Perinatology, Etlik City Hospital, Ankara, Turkey. FAU - Celen, Sevki AU - Celen S AUID- ORCID: 0000-0001-7033-3474 AD - Department of Perinatology, Etlik City Hospital, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260504 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - 0 (Biomarkers) RN - 0 (Serum Albumin) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Pre-Eclampsia/blood MH - Case-Control Studies MH - Adult MH - Biomarkers/blood MH - Retrospective Studies MH - *Serum Albumin/analysis/metabolism MH - ROC Curve MH - Pregnancy Outcome MH - Logistic Models MH - *Inflammation/blood MH - Predictive Value of Tests MH - Infant, Newborn PMC - PMC13285206 OTO - NOTNLM OT - Albumin-based inflammatory indices OT - Blood urea nitrogen-to-albumin ratio (BAR) OT - Composite adverse perinatal outcome OT - Neonatal outcomes OT - Preeclampsia COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the Ankara Etlik City Hospital Ethics Committee No. 2 (approval number: AESH-BADEK2-2025-459), and written informed consent was obtained from all participants. The study adhered to the ethical principles outlined in the Declaration of Helsinki. Consent for publication: Not applicable. This study does not contain any individual person's data in any form (including any individual details, images, or videos) that would require consent for publication. Competing interests: The authors declare no competing interests. EDAT- 2026/05/04 00:31 MHDA- 2026/06/22 18:58 PMCR- 2026/05/04 CRDT- 2026/05/03 23:54 PHST- 2025/11/09 00:00 [received] PHST- 2026/04/30 00:00 [accepted] PHST- 2026/06/22 18:58 [medline] PHST- 2026/05/04 00:31 [pubmed] PHST- 2026/05/03 23:54 [entrez] PHST- 2026/05/04 00:00 [pmc-release] AID - 10.1186/s12884-026-09208-9 [pii] AID - 9208 [pii] AID - 10.1186/s12884-026-09208-9 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 May 4;26(1):670. doi: 10.1186/s12884-026-09208-9. PMID- 42070968 OWN - NLM STAT- MEDLINE DCOM- 20260610 LR - 20260610 IS - 2191-0251 (Electronic) IS - 0334-018X (Linking) VI - 39 IP - 5 DP - 2026 May 26 TI - Automatic bone age assessment for adult height prediction in children with congenital adrenal hyperplasia. PG - 464-471 LID - 10.1515/jpem-2026-0101 [doi] AB - OBJECTIVES: This study aimed to evaluate the clinical accuracy of automated BoneXpert (BX) vs. clinician-based Greulich-Pyle (GP) bone age (BA) assessments by comparing their respective predicted adult heights (PAH) with near-final height (NFH) in patients with congenital adrenal hyperplasia (CAH). METHODS: Forty-seven patients with classic salt-wasting CAH diagnosed in the neonatal period who had reached NFH were included. Left hand-wrist radiographs obtained during the prepubertal period (6-9 years) were evaluated manually by two clinicians using the GP atlas and by the BX-GP method. PAH was calculated for both sexes using the Bayley-Pinneau (BP) method based on clinician- and BX-derived BA. PAH standard deviation scores (SDS) were compared with NFH-SDS and target height (TH)-SDS. Agreement was assessed using Bland-Altman analysis. RESULTS: Thirty patients (63.8 %) were female. Mean ages at bone age assessment and NFH were 7.3 and 16.1 years, respectively. Mean prepubertal height-SDS was 0.0 in girls and -0.25 in boys, while NFH-SDS was -0.79 and -1.14, respectively. Mean bone age according to clinician-GP was 7.80 years in girls and 8.16 in boys, and 7.69 and 8.14 years according to BX-GP. Clinician-based PAH-SDS was -1.0 in girls and -1.18 in boys, whereas BX-based PAH-SDS was -0.86 and -1.17, respectively. BX-based PAH was closer to NFH in girls (p<0.001), with no significant difference in boys. In both sexes, PAH-SDS and NFH-SDS were significantly lower than TH-SDS (p<0.001). CONCLUSIONS: PAH calculations using the BP method based on BX-derived GP bone age readings more accurately predicted NFH in patients with CAH. CI - (c) 2026 Walter de Gruyter GmbH, Berlin/Boston. FAU - Cetin, Kursat AU - Cetin K AUID- ORCID: 0000-0002-9022-4010 AD - Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkiye. FAU - Cetiner, Ebru Barsal AU - Cetiner EB AUID- ORCID: 0000-0002-1888-919X AD - Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkiye. FAU - Bahar, Yasemin Funda AU - Bahar YF AUID- ORCID: 0000-0001-9022-5294 AD - Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkiye. FAU - Tirtar, Ali AU - Tirtar A AUID- ORCID: 0009-0001-9924-9775 AD - Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkiye. FAU - Parlak, Mesut AU - Parlak M AUID- ORCID: 0000-0002-3550-1425 AD - Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkiye. FAU - Tuhan, Hale AU - Tuhan H AUID- ORCID: 0000-0002-7637-9630 AD - Department of Pediatric Endocrinology, Akdeniz University Hospital, Antalya, Turkiye. LA - eng PT - Journal Article DEP - 20260505 PL - Germany TA - J Pediatr Endocrinol Metab JT - Journal of pediatric endocrinology & metabolism : JPEM JID - 9508900 SB - IM MH - Humans MH - *Adrenal Hyperplasia, Congenital/physiopathology MH - Male MH - Female MH - Child MH - *Body Height MH - *Age Determination by Skeleton/methods MH - Adolescent MH - Prognosis MH - Follow-Up Studies OTO - NOTNLM OT - BoneXpert OT - bone age OT - congenital adrenal hyperplasia OT - near final height OT - predicted adult height EDAT- 2026/05/04 00:31 MHDA- 2026/06/11 05:43 CRDT- 2026/05/03 22:02 PHST- 2026/02/13 00:00 [received] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/06/11 05:43 [medline] PHST- 2026/05/04 00:31 [pubmed] PHST- 2026/05/03 22:02 [entrez] AID - jpem-2026-0101 [pii] AID - 10.1515/jpem-2026-0101 [doi] PST - epublish SO - J Pediatr Endocrinol Metab. 2026 May 5;39(5):464-471. doi: 10.1515/jpem-2026-0101. Print 2026 May 26. PMID- 42069973 OWN - NLM STAT- Publisher LR - 20260502 IS - 1559-064X (Electronic) IS - 1559-0631 (Linking) DP - 2026 May 2 TI - Exploring saliva as a biofluid for biomonitoring of diet-related contaminants exposure: insights from a literature mining approach. LID - 10.1038/s41370-026-00887-2 [doi] AB - BACKGROUND: Human biomonitoring (HBM) is crucial for evaluating exposure to diet-related contaminants, whose effects may pose substantial health risks. Saliva is recognized as a promising non-invasive biological matrix due to its ease of collection and potential to reflect external and systemic exposure. However, suitability for monitoring dietary hazardous compounds remains uncertain. OBJECTIVE: To assess the potential of saliva as a biomonitoring matrix for diet-related contaminants, identify compounds with robust diet-related associations, and highlight knowledge gaps. METHODS: A systematic literature review was conducted to screen over 500 diet-related contaminants analyzed in saliva. Detailed information was extracted only for contaminants quantitatively measured in saliva, including concentration ranges, sample sizes, and analytical methods. Evidence of correlations with systemic concentrations, exposure pathways, and individual or lifestyle factors was compiled into a FAIR database to provide an integrated evaluation of saliva's biomonitoring potential. RESULTS: Only a limited subset of contaminant groups, including nitrite/nitrate, heavy metals, bisphenols, polycyclic aromatic hydrocarbons (PAHs), biogenic amines, pesticides, advanced glycation end products (AGEs), perchlorate, microplastics (MPs), parabens and phthalates, have been quantitatively measured in saliva. Compounds such as nitrate, arsenic, AGEs, pesticides and perchlorate demonstrate moderate to strong correlations between salivary and systemic levels, supporting saliva's potential to estimate exposure. Conversely, substances like PAHs, MPs, phthalates and parabens generally show weak or no correlation, reflecting recent or localised exposures rather than cumulative burden. Salivary composition is influenced by intrinsic and extrinsic factors, including diet, oral microbiota, physiology, and sampling conditions, resulting in high interindividual variability. SIGNIFICANCE: Despite challenges, low salivary concentrations and lack of standardized collection protocols, saliva offers advantages for biomonitoring vulnerable populations, such as children and pregnant women. Harmonized collection procedures, validated sensitive methods, predictive models accounting for variability and exposure context, could establish saliva as a reliable complementary or alternative matrix for assessing human exposure to dietary and environmental contaminants. IMPACT: This systematic review synthesizes findings from 104 studies, covering over 500 diet-related contaminants measured in saliva, and compiles them into a FAIR database, providing the most comprehensive resource to date for saliva-based biomonitoring. Compounds such as nitrate, arsenic, advanced glycation end-products (AGEs), pesticides, and perchlorate show meaningful correlations with systemic levels, supporting saliva's potential as a non-invasive matrix for assessing human exposure. To fully realize saliva's potential, standardized collection protocols, validated analytical methods, and predictive models that account for interindividual variability and exposure context are urgently needed, enabling more accurate and ethical monitoring of vulnerable populations. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature America, Inc. FAU - Reis-Mendes, A AU - Reis-Mendes A AUID- ORCID: 0000-0002-2775-3147 AD - LAQV/REQUIMTE, Departamento de Ciencias Quimicas, Laboratorio de Bromatologia e Hidrologia, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal. afreis.mendes@gmail.com. FAU - Lisboa, L AU - Lisboa L AD - LAQV/REQUIMTE, Departamento de Ciencias Quimicas, Laboratorio de Bromatologia e Hidrologia, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal. FAU - Martins, Z AU - Martins Z AD - LAQV/REQUIMTE, Departamento de Ciencias Quimicas, Laboratorio de Bromatologia e Hidrologia, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal. FAU - Borges, C B AU - Borges CB AD - LAQV/REQUIMTE, Departamento de Ciencias Quimicas, Laboratorio de Bromatologia e Hidrologia, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal. FAU - Araujo, A M AU - Araujo AM AD - LAQV/REQUIMTE, Departamento de Ciencias Quimicas, Laboratorio de Bromatologia e Hidrologia, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal. FAU - Ramos, H AU - Ramos H AD - LAQV/REQUIMTE, Departamento de Ciencias Quimicas, Laboratorio de Bromatologia e Hidrologia, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal. FAU - Melo, A AU - Melo A AD - National Institute of Health Doutor Ricardo Jorge, Department of Environmental Health, Porto, Portugal. AD - LAQV/REQUIMTE, Universidade do Porto, Porto, Portugal. FAU - Faria, M A AU - Faria MA AD - LAQV/REQUIMTE, Departamento de Ciencias Quimicas, Laboratorio de Bromatologia e Hidrologia, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal. FAU - Ferreira, I M P L V O AU - Ferreira IMPLVO AD - LAQV/REQUIMTE, Departamento de Ciencias Quimicas, Laboratorio de Bromatologia e Hidrologia, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal. isabel.ferreira@ff.up.pt. LA - eng PT - Journal Article PT - Review DEP - 20260502 PL - United States TA - J Expo Sci Environ Epidemiol JT - Journal of exposure science & environmental epidemiology JID - 101262796 SB - IM OTO - NOTNLM OT - Biomonitoring OT - Dietary exposure OT - Environmental Monitoring OT - systematic review COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/05/03 05:27 MHDA- 2026/05/03 05:27 CRDT- 2026/05/02 23:27 PHST- 2025/10/16 00:00 [received] PHST- 2026/03/29 00:00 [accepted] PHST- 2026/03/12 00:00 [revised] PHST- 2026/05/03 05:27 [medline] PHST- 2026/05/03 05:27 [pubmed] PHST- 2026/05/02 23:27 [entrez] AID - 10.1038/s41370-026-00887-2 [pii] AID - 10.1038/s41370-026-00887-2 [doi] PST - aheadofprint SO - J Expo Sci Environ Epidemiol. 2026 May 2. doi: 10.1038/s41370-026-00887-2. PMID- 42069593 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260813 IS - 1475-9276 (Electronic) IS - 1475-9276 (Linking) VI - 25 IP - 1 DP - 2026 May 2 TI - Experiences of discrimination, paternal support, and hypertensive disorders of pregnancy (HDP) in the MIEHR study, Houston, Texas. LID - 10.1186/s12939-026-02864-5 [doi] LID - 154 AB - BACKGROUND: Discrimination is a psychosocial stressor that, through activation of stress-response pathways, may influence risk of adverse perinatal health outcomes. However, few studies have evaluated the association between discrimination and hypertensive disorders of pregnancy (HDP), and none have explored effect modification by race or paternal support, which may buffer the adverse effects of discrimination. METHODS: We included 1,847 non-Hispanic Black and White participants from the Maternal and Infant Environmental Health Riskscape (MIEHR) study. Krieger's validated Experiences of Discrimination (EOD) scale was used to assess occurrence (yes/no) and frequency (once, 2-3, >/= 4 times) of discrimination in nine situations. We created continuous scores representing total situations and frequency and also categorized (0, 1-2, >/= 3) the situations score. Using electronic health records, we identified participants with HDP (hypertension in pregnancy, preeclampsia, eclampsia, and hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome). We applied log-binomial regression to evaluate associations between experiences of discrimination and HDP, adjusted for maternal age, pre-pregnancy body mass index, income, and race. Analyses were stratified by race and self-reported paternal support (none/a little vs. good/excellent) as potential effect modifiers; due to small numbers, the situation score was dichotomized (0, >/= 1) for these analyses. RESULTS: HDP occurred in 37.5% (n = 430) of Black and 26.0% (n = 182) of White participants. Compared with participants reporting no discrimination, the adjusted risk ratio (aRR) was 1.13 (95% CI: 0.96, 1.33) and 1.11 (95% CI: 0.94, 1.30) for those reporting discrimination in 1-2 and >/= 3 situations, respectively. By setting, the strongest associations were observed for discrimination in getting a job (aRR: 1.22; 95% CI: 1.14, 1.43), by police (aRR: 1.21; 95% CI: 1.01, 1.44), and getting medical care (aRR: 1.17; 95% CI: 0.94, 1.44). Stratified analyses revealed the strongest associations between experiencing discrimination and HDP among Black participants and those with lower perceptions of paternal support. CONCLUSIONS: We found associations between discrimination and HDP among Black participants, who bear the greatest burden of HDP, as well as a potential buffering effect of paternal support. Future research is needed to investigate associations between discrimination and HDP and evaluate whether enhancing paternal support can mitigate the impact of discrimination on HDP risk. CI - (c) 2026. The Author(s). FAU - Alinia, Tahereh AU - Alinia T AD - Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA. FAU - Symanski, Elaine AU - Symanski E AD - Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA. AD - Department of Medicine, Section of Epidemiology and Population Sciences, Baylor College of Medicine, Houston, TX, USA. FAU - Alvarez, Juan Manuel AU - Alvarez JM AD - Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA. FAU - Whitworth, Kristina Walker AU - Whitworth KW AD - Center for Precision Environmental Health, Baylor College of Medicine, Houston, TX, USA. kristina.whitworth@bcm.edu. AD - Department of Medicine, Section of Epidemiology and Population Sciences, Baylor College of Medicine, Houston, TX, USA. kristina.whitworth@bcm.edu. LA - eng GR - P50 MD015496/MD/NIMHD NIH HHS/United States PT - Journal Article DEP - 20260502 PL - England TA - Int J Equity Health JT - International journal for equity in health JID - 101147692 SB - IM MH - Adult MH - Female MH - Humans MH - Male MH - Pregnancy MH - Black or African American/psychology MH - *Fathers/psychology MH - *Hypertension, Pregnancy-Induced/epidemiology/ethnology/psychology MH - *Racism MH - Texas/epidemiology MH - White/psychology PMC - PMC13285525 OTO - NOTNLM OT - Discrimination OT - Hypertensive disorders of pregnancy OT - Paternal support OT - Race COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the Institutional Review Boards at Baylor College of Medicine and The University of Texas Health Science Center at Houston. Informed consent was obtained from all participants in this study. The research was conducted in accordance with the principles of the Belmont Report and the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/03 05:27 MHDA- 2026/06/22 18:58 PMCR- 2026/05/02 CRDT- 2026/05/02 23:15 PHST- 2025/08/21 00:00 [received] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/06/22 18:58 [medline] PHST- 2026/05/03 05:27 [pubmed] PHST- 2026/05/02 23:15 [entrez] PHST- 2026/05/02 00:00 [pmc-release] AID - 10.1186/s12939-026-02864-5 [pii] AID - 2864 [pii] AID - 10.1186/s12939-026-02864-5 [doi] PST - epublish SO - Int J Equity Health. 2026 May 2;25(1):154. doi: 10.1186/s12939-026-02864-5. PMID- 42069557 OWN - NLM STAT- MEDLINE DCOM- 20260619 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 May 2 TI - The study protocol of the ePro-Schools project: an eHealth program for promoting physical activity and healthy nutrition in schools. LID - 10.1186/s12889-026-27587-8 [doi] LID - 1922 AB - BACKGROUND: Early adolescence is key for adopting healthier lifestyles, yet disadvantaged communities often lack resources to support these changes, perpetuating health inequities. Schools play a crucial role in promoting physical activity and healthy eating. eHealth solutions, like online platforms, offer scalable, cost-effective ways to deliver interventions. These platforms can also enhance adolescent engagement and help bridge health resource gaps. The ePro-Schools project aims to co-design and test an eHealth platform to promote healthy habits among adolescents in socially disadvantaged settings. METHODS: A randomized controlled trial (RCT) will be carried out with the participation of 6 secondary schools (three controls and three intervention), with a sample size estimated at 1000 students of Central Catalonia (Spain). In the intervention schools, focus groups sessions and meetings with stakeholders have been conducted to co-create the ePro-Schools eHealth platform. Students and school staff are pilot testing the platform to assess the platform's usability, functionality, and layout. Finally, the RCT will be conducted, in which the intervention group will have full access to the ePro-Schools platform (an interactive and informative platform), while the control group will only have access to the informative platform with health literacy content on physical activity, nutrition, and healthy habits. In both groups, adolescents will complete validated questionnaires at baseline, post-intervention, and at the six-month follow-up to assess their physical activity and eating habits, including depressive symptoms, quality of life, social isolation, and mental health. Sociodemographic characteristics will also be collected. Implementation, effectiveness, and cost-effectiveness analysis will be performed. DISCUSSION: The ePro-Schools project introduces a co-designed eHealth platform that integrates physical activity and healthy eating promotion within schools. The intervention aims to enhance adoption, relevance, and sustainability across diverse settings. ePro-Schools project could reduce health inequalities, improve adolescents' physical and mental well-being, and strengthen daily health habits. The model's scalability and embedded implementation planning may support long-term integration into school systems, informing future policies and contributing to educational engagement, reduced disease risk, and broader population health impact. TRIAL REGISTRATION: This trial is registered in ClinicalTrials.gov, with the registration number NCT06792461. CI - (c) 2026. The Author(s). FAU - Mas, Eugeni AU - Mas E AD - Unitat de Suport a La Recerca de La Catalunya Central, Institut Universitari Per a La Recerca a L'Atencio Primaria de Salut Jordi Gol I Gurina (IDIAPJGol), Manresa, Spain. FAU - Moreno-Martinez, Marina AU - Moreno-Martinez M AD - Unitat de Recerca I Innovacio, Gerencia d'Atencio Primaria I a La Comunitat de La Catalunya Central, Institut Catala de La Salut, Soler I March Street, 6, 5th floor, 08242, Barcelona, Manresa, Spain. mmorenom.cc.ics@gencat.cat. AD - Intelligence for Primary Care Research Group, Fundacio Institut Universitari Per a La Recerca a L'Atencio Primaria de Salut Jordi Gol I Gurina, Manresa, Spain. mmorenom.cc.ics@gencat.cat. FAU - Gascon, Mireia AU - Gascon M AD - Unitat de Suport a La Recerca de La Catalunya Central, Institut Universitari Per a La Recerca a L'Atencio Primaria de Salut Jordi Gol I Gurina (IDIAPJGol), Manresa, Spain. FAU - Espelt, Albert AU - Espelt A AD - Consorcio Centro Investigacion Biomedica en RED (CIBER)-SAM and Impact and Prevention of Mental Disorders, Barcelona, Spain. AD - Universitat Autonoma de Barcelona (UAB), Barcelona, Spain. FAU - Pryss, Rudiger AU - Pryss R AD - Institute of Medical Data Science, University Hospital Wurzburg, Wurzburg, Germany. AD - Institute of Clinical Epidemiology and Biometry, University of Wurzburg, Wurzburg, Germany. FAU - van der Waerden, Judith AU - van der Waerden J AD - Sorbonne Universite, INSERM, Institut Pierre Louis d'Epidemiologie Et de Sante Publique (IPLESP), Epidemiologie Sociale, Sante Mentale Et Addictions (ESSMA), Paris, France. FAU - Pilato, Jade AU - Pilato J AD - Sorbonne Universite, INSERM, Institut Pierre Louis d'Epidemiologie Et de Sante Publique (IPLESP), Epidemiologie Sociale, Sante Mentale Et Addictions (ESSMA), Paris, France. FAU - Agostinis-Sobrinho, Cesar AU - Agostinis-Sobrinho C AD - Health Research and Innovation Science Centre, Klaipeda University, Klaipeda, Lithuania. FAU - Stevens, Gonneke AU - Stevens G AD - Department of Interdisciplinary Social Science (UU), Utrecht University, Utrecht, Netherlands. FAU - Gobina, Inese AU - Gobina I AD - Insitute of Public Health, Rigas Stradins Universitaty (RSU), Riga, Latvia. FAU - Kraft, Robin AU - Kraft R AD - Institute of Medical Data Science, University Hospital Wurzburg, Wurzburg, Germany. AD - Institute of Clinical Epidemiology and Biometry, University of Wurzburg, Wurzburg, Germany. FAU - Vogel, Carsten AU - Vogel C AD - Institute of Medical Data Science, University Hospital Wurzburg, Wurzburg, Germany. AD - Institute of Clinical Epidemiology and Biometry, University of Wurzburg, Wurzburg, Germany. FAU - Stach, Michael AU - Stach M AD - Institute of Medical Data Science, University Hospital Wurzburg, Wurzburg, Germany. AD - Institute of Clinical Epidemiology and Biometry, University of Wurzburg, Wurzburg, Germany. FAU - Koehler, Karsten AU - Koehler K AD - Department of Health and Sport Sciences, Technical University of Munich, Munich, Germany. FAU - Perez-Anton, Mariona AU - Perez-Anton M AD - Parc Sanitari Sant Joan de Deu, Barcelona, Spain. AD - Impact and Prevention of Mental Disorders Research Group, Sant Joan de Deu Research Institute, Barcelona, Spain. FAU - Sanguesa, Julia AU - Sanguesa J AD - Parc Sanitari Sant Joan de Deu, Barcelona, Spain. AD - Impact and Prevention of Mental Disorders Research Group, Sant Joan de Deu Research Institute, Barcelona, Spain. FAU - Melo, Geiziane AU - Melo G AD - Health Research and Innovation Science Centre, Klaipeda University, Klaipeda, Lithuania. FAU - Espirito Santo, Rafaela C AU - Espirito Santo RC AD - Health Research and Innovation Science Centre, Klaipeda University, Klaipeda, Lithuania. FAU - Haro, Josep Maria AU - Haro JM AD - Consorcio Centro Investigacion Biomedica en RED (CIBER)-SAM and Impact and Prevention of Mental Disorders, Barcelona, Spain. AD - Parc Sanitari Sant Joan de Deu, Barcelona, Spain. AD - Impact and Prevention of Mental Disorders Research Group, Sant Joan de Deu Research Institute, Barcelona, Spain. FAU - Bosque-Prous, Marina AU - Bosque-Prous M AD - Research Group in Epidemiology and Public Health in the Digital Health Context (Epi4health), Faculty of Health Sciences, Universitat Oberta de Catalunya, Barcelona, Spain. AD - Department of Psychobiology and Methodology in Health Sciences, Universitat Autonoma de Barcelona (UAB), Bellaterra, Spain. AD - Centro de Investigacion Biomedica en Red de Epidemiologia y Salud Publica (CIBERESP), Madrid, Spain. FAU - Aguilar-Martinez, Alicia AU - Aguilar-Martinez A AD - Research Group in Epidemiology and Public Health in the Digital Health Context (Epi4health), Faculty of Health Sciences, Universitat Oberta de Catalunya, Barcelona, Spain. FAU - Esquius, Laura AU - Esquius L AD - Research Group in Epidemiology and Public Health in the Digital Health Context (Epi4health), Faculty of Health Sciences, Universitat Oberta de Catalunya, Barcelona, Spain. FAU - Massip-Salcedo, Marta AU - Massip-Salcedo M AD - Research Group in Epidemiology and Public Health in the Digital Health Context (Epi4health), Faculty of Health Sciences, Universitat Oberta de Catalunya, Barcelona, Spain. AD - Barcelona Beta Brain Research Center, Pasqual Maragall Foundation, Barcelona, Catalonia, Spain. FAU - Chiva-Blanch, Gemma AU - Chiva-Blanch G AD - NUTRALiSS Research Group, Faculty of Health Sciences, Universitat Oberta de Catalunya (UOC), Barcelona, Spain. AD - Biomedical Network Research Centre On Obesity and Nutrition Physiopathology (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Vidal-Alaball, Josep AU - Vidal-Alaball J AD - Unitat de Suport a La Recerca de La Catalunya Central, Institut Universitari Per a La Recerca a L'Atencio Primaria de Salut Jordi Gol I Gurina (IDIAPJGol), Manresa, Spain. AD - Unitat de Recerca I Innovacio, Gerencia d'Atencio Primaria I a La Comunitat de La Catalunya Central, Institut Catala de La Salut, Soler I March Street, 6, 5th floor, 08242, Barcelona, Manresa, Spain. AD - Intelligence for Primary Care Research Group, Fundacio Institut Universitari Per a La Recerca a L'Atencio Primaria de Salut Jordi Gol I Gurina, Manresa, Spain. AD - Department of Medicine, Faculty of Medicine, University of Vic-Central, University of Catalonia, Vic, Spain. FAU - Lima, Rodrigo AU - Lima R AD - Consorcio Centro Investigacion Biomedica en RED (CIBER)-SAM and Impact and Prevention of Mental Disorders, Barcelona, Spain. AD - Parc Sanitari Sant Joan de Deu, Barcelona, Spain. AD - Impact and Prevention of Mental Disorders Research Group, Sant Joan de Deu Research Institute, Barcelona, Spain. LA - eng SI - ClinicalTrials.gov/NCT06792461 GR - GA N degrees 101095426/Instituto de Salud Carlos III (ISC-III) under the umbrella of the Partnership Fostering a European Research Area for Health (ERA4Health)/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20260502 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - *Diet, Healthy MH - *Exercise MH - Focus Groups MH - *Health Promotion/methods/organization & administration MH - *School Health Services/organization & administration MH - Schools MH - Spain MH - *Telemedicine MH - Randomized Controlled Trials as Topic PMC - PMC13281623 OTO - NOTNLM OT - Adolescents OT - EHealth OT - Health policies OT - Nutrition OT - Physical activity OT - Randomized controlled trial COIS- Declarations. Ethics approval and consent to participate: The study was approved by the IDIAP Jordi Gol clinical research ethics committee with registration code 24/099-P. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/03 05:27 MHDA- 2026/06/19 06:32 PMCR- 2026/05/02 CRDT- 2026/05/02 23:14 PHST- 2026/01/14 00:00 [received] PHST- 2026/04/23 00:00 [accepted] PHST- 2026/06/19 06:32 [medline] PHST- 2026/05/03 05:27 [pubmed] PHST- 2026/05/02 23:14 [entrez] PHST- 2026/05/02 00:00 [pmc-release] AID - 10.1186/s12889-026-27587-8 [pii] AID - 27587 [pii] AID - 10.1186/s12889-026-27587-8 [doi] PST - epublish SO - BMC Public Health. 2026 May 2;26(1):1922. doi: 10.1186/s12889-026-27587-8. PMID- 42068652 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1879-1379 (Electronic) IS - 0022-3956 (Print) IS - 0022-3956 (Linking) VI - 199 DP - 2026 Aug TI - Urinary pesticide biomarker associations with depression and anxiety scores from adolescence into young adulthood in the ESPINA cohort. PG - 175-188 LID - S0022-3956(26)00234-7 [pii] LID - 10.1016/j.jpsychires.2026.04.023 [doi] AB - INTRODUCTION: Growing evidence suggests pesticide exposure can affect emotional well-being; limited research exists across adolescence and young adulthood. We examined cross-sectional and longitudinal associations of pesticide biomarkers with anxiety and depression scores. METHODS: We analyzed 646 participants from Ecuadorian agricultural communities: 510 in 2016 (ages 11-17y) and 485 in 2022 (17-24y). Twelve urinary insecticide metabolites were measured. Validated questionnaires assessed depression and anxiety. Generalized estimating equations (GEE) estimated associations for continuous scores and logit GEE calculated odds ratios (OR) of elevated symptoms, adjusting for demographic and anthropometric variables. RESULTS: In 2016, an interquartile range higher overall pesticides summed (beta = 1.01 95%CI:[0.48, 1.53]), organophosphates summed (beta = 0.99 [0.47, 1.51]), 3,5,6-trichloro-2-pyridinol (TCPy; beta = 0.97 [0.49, 1.45]), pyrethroids summed (beta = 0.69 [0.11, 1.27]) and 3-phenoxybenzoic acid (beta = 0.31 [0.01, 0.61]) were positively associated with depression. Detectable 5-hydroxy imidacloprid (OHIM) doubled elevated depression odds. In 2022, higher sulfoxaflor isomers were protective, but higher clothianidin increased elevated depression odds. Longitudinally, depression was positively associated with overall pesticides summed (beta = 0.06 [0.02, 0.11]), organophosphates summed (beta = 0.05 [0.001, 0.10]), TCPy (beta = 0.06 [0.02, 0.10]), pyrethroids summed and trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (trans-DCCA; beta = 0.01 [0.003, 0.02]). For anxiety, in 2016 detectable trans-DCCA (OR = 2.52 [1.52, 4.16]) was associated with elevated symptoms. In 2022, higher clothianidin increased elevated anxiety odds (OR = 1.44 [1.07, 1.93]). Longitudinally, trans-DCCA (OR = 1.39 [1.03, 1.87]) and OHIM (OR = 1.44 [1.02, 2.04]) increased elevated anxiety odds. CONCLUSIONS: Organophosphates, pyrethroids, and neonicotinoids were generally linked to higher depression and anxiety, while sulfoximines and one organophosphate appeared protective. OHIM and trans-DCCA showed consistent adverse associations across years. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Chronister, Briana N C AU - Chronister BNC AD - Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, 92093, USA; School of Public Health, San Diego State University, San Diego, CA, 92182, USA. FAU - Hussari, Mohammed N AU - Hussari MN AD - School of Medicine, University of California San Diego (UCSD), La Jolla, CA, USA. FAU - Lopez-Paredes, Dolores AU - Lopez-Paredes D AD - Fundacion Cimas del Ecuador, Quito, Ecuador. FAU - Checkoway, Harvey AU - Checkoway H AD - Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, 92093, USA. FAU - Suarez-Torres, Jose AU - Suarez-Torres J AD - Fundacion Cimas del Ecuador, Quito, Ecuador. FAU - Gahagan, Sheila AU - Gahagan S AD - Department of Pediatrics, University of California, La Jolla, San Diego, CA, 92093, USA. FAU - Bradman, Asa AU - Bradman A AD - Department of Public Health, School of Social Sciences, Humanities, and Arts, University of California, Merced, CA, USA. FAU - Martinez, Danilo AU - Martinez D AD - Fundacion Cimas del Ecuador, Quito, Ecuador. FAU - Hong, Suzi AU - Hong S AD - Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, 92093, USA. FAU - Moore, Raeanne C AU - Moore RC AD - Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA. FAU - Suarez-Lopez, Jose R AU - Suarez-Lopez JR AD - Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, La Jolla, CA, 92093, USA. Electronic address: jrsuarez@health.ucsd.edu. LA - eng GR - U2C ES026560/ES/NIEHS NIH HHS/United States GR - R21 ES026084/ES/NIEHS NIH HHS/United States GR - R01 ES025792/ES/NIEHS NIH HHS/United States GR - T32 MH122376/MH/NIMH NIH HHS/United States GR - R01 ES030378/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260423 PL - England TA - J Psychiatr Res JT - Journal of psychiatric research JID - 0376331 RN - 0 (Pesticides) RN - 0 (Biomarkers) RN - 0 (Organophosphates) RN - 0 (Pyridones) RN - 0 (Pyrethrins) RN - 6515-38-4 (3,5,6-trichloro-2-pyridinol) SB - IM UOF - medRxiv. 2025 Dec 12:2025.12.10.25341988. doi: 10.64898/2025.12.10.25341988. PMID: 41415499 MH - Humans MH - Male MH - Female MH - Adolescent MH - *Depression/epidemiology/chemically induced/urine MH - *Anxiety/epidemiology/chemically induced/urine MH - *Pesticides/urine MH - Longitudinal Studies MH - Young Adult MH - Ecuador/epidemiology MH - Biomarkers/urine MH - Child MH - Cross-Sectional Studies MH - Organophosphates/urine MH - Pyridones/urine MH - Pyrethrins/urine MH - Cohort Studies PMC - PMC13286626 MID - NIHMS2173723 COIS- Declaration of competing interest RCM is a co-founder, has equity interest, is a consultant and receives compensation from NeuroUX, a company that develops mobile cognitive tests. The terms of this arrangement have been reviewed and approved by UC San Diego in accordance with its conflict of interest policies. All other authors report having no conflicts of interest. EDAT- 2026/05/03 05:27 MHDA- 2026/05/24 04:38 PMCR- 2026/06/22 CRDT- 2026/05/02 18:02 PHST- 2025/12/10 00:00 [received] PHST- 2026/02/17 00:00 [revised] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/05/24 04:38 [medline] PHST- 2026/05/03 05:27 [pubmed] PHST- 2026/05/02 18:02 [entrez] PHST- 2026/06/22 00:00 [pmc-release] AID - S0022-3956(26)00234-7 [pii] AID - 10.1016/j.jpsychires.2026.04.023 [doi] PST - ppublish SO - J Psychiatr Res. 2026 Aug;199:175-188. doi: 10.1016/j.jpsychires.2026.04.023. Epub 2026 Apr 23. PMID- 42068470 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260914 IS - 1559-0100 (Electronic) IS - 1355-008X (Print) IS - 1355-008X (Linking) VI - 91 IP - 1 DP - 2026 May 2 TI - Developmental stages and exercise timing in relation to fear of hypoglycemia and quality of life in type 1 diabetes. LID - 10.1007/s12020-026-04632-5 [doi] LID - 162 AB - PURPOSE: To examine associations between physical activity (PA) characteristics and psychosocial outcomes - quality of life (QoL) and fear of hypoglycemia (FH) - in children, adolescents, and young adults with type 1 diabetes (T1D). METHODS: In this cross-sectional study, 100 insulin pump-treated outpatients T1D completed 7-day PA logs capturing timing, type, intensity, and volume. QoL and FH were assessed using age-appropriate validated instruments. General linear models evaluated associations between PA characteristics and psychosocial outcomes, accounting for age group and, in sensitivity analyses, sex and HbA1c. RESULTS: In pooled analyses (N = 82 complete cases), age group was significantly associated with both QoL (p = 0.037) and FH (p < 0.001), with a large effect size observed for FH. In sensitivity analyses adjusting for sex and HbA1c, the age-group effect on FH remained robust, whereas associations with QoL were attenuated. Exercise timing was associated with FH (p = 0.047), with higher adjusted FH scores observed among individuals reporting evening exercise. However, pairwise comparisons were not significant after correction. No significant AgeGroupxTiming interactions were detected. Preferred exercise type and intensity were not independently associated with psychosocial outcomes. In sensitivity analyses adjusted for sex and HbA1c (N = 62), the age-group effect on FH remained robust, whereas timing showed borderline significance. CONCLUSION: Developmental stage appears to be a major determinant of fear of hypoglycemia in youths with T1D. Exercise timing may contribute modestly to perceived hypoglycemia risk, particularly for evening activity, although findings were attenuated after adjustment. These cross-sectional associations highlight the importance of developmentally tailored exercise counselling, while longitudinal studies are needed to clarify directionality. CI - (c) 2026. The Author(s). FAU - Codella, Roberto AU - Codella R AD - Department of Endocrinology, Nutrition and Metabolic Diseases, IRCCS MultiMedica, Milan, 20138, Italy. roberto.codella@unimi.it. AD - Department of Biomedical Sciences for Health, Universita degli Studi di Milano, Milan, 20133, Italy. roberto.codella@unimi.it. FAU - Bisio, Ambra AU - Bisio A AD - Centro Polifunzionale di Scienze Motorie, University of Genoa, Genoa, 16132, Italy. AD - Department of Experimental Medicine, Section of Human Physiology, University of Genoa, Genoa, 16132, Italy. FAU - Gotti, Daniel AU - Gotti D AD - Department of Biomedical Sciences for Health, Universita degli Studi di Milano, Milan, 20133, Italy. FAU - Bassi, Marta AU - Bassi M AD - Pediatric Clinic, IRCCS Istituto Giannina Gaslini, University of Genoa, Genoa, Italy. FAU - Minuto, Nicola AU - Minuto N AD - Pediatric Clinic, IRCCS Istituto Giannina Gaslini, University of Genoa, Genoa, Italy. FAU - Ruggeri, Piero AU - Ruggeri P AD - Centro Polifunzionale di Scienze Motorie, University of Genoa, Genoa, 16132, Italy. AD - Department of Experimental Medicine, Section of Human Physiology, University of Genoa, Genoa, 16132, Italy. FAU - Luzi, Livio AU - Luzi L AD - Department of Endocrinology, Nutrition and Metabolic Diseases, IRCCS MultiMedica, Milan, 20138, Italy. AD - Department of Biomedical Sciences for Health, Universita degli Studi di Milano, Milan, 20133, Italy. FAU - Maggi, Davide AU - Maggi D AD - IRCCS San Martino, University of Genoa, Genoa, Italy. FAU - Faelli, Emanuela AU - Faelli E AD - Centro Polifunzionale di Scienze Motorie, University of Genoa, Genoa, 16132, Italy. AD - Department of Experimental Medicine, Section of Human Physiology, University of Genoa, Genoa, 16132, Italy. LA - eng PT - Journal Article DEP - 20260502 PL - United States TA - Endocrine JT - Endocrine JID - 9434444 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/psychology/drug therapy/blood MH - *Hypoglycemia/psychology MH - *Quality of Life/psychology MH - Female MH - *Fear/psychology MH - Male MH - Adolescent MH - Cross-Sectional Studies MH - *Exercise/psychology/physiology MH - Child MH - Young Adult MH - Adult PMC - PMC13135517 OTO - NOTNLM OT - Type 1 diabetes OT - exercise timing OT - fear of hypoglycemia OT - pediatric endocrinology OT - physical activity OT - quality of life COIS- Declarations. Consent to participate: Written informed consent was obtained from all participants or their legal guardians. Study approval: This study protocol was reviewed and approved by the Ethics Committee of the University of Genoa, Italy, approval number 23/2023. Conflict of interests: The authors declare no competing interests. EDAT- 2026/05/03 05:22 MHDA- 2026/05/03 05:23 PMCR- 2026/05/02 CRDT- 2026/05/02 11:07 PHST- 2026/01/09 00:00 [received] PHST- 2026/03/28 00:00 [accepted] PHST- 2026/05/03 05:23 [medline] PHST- 2026/05/03 05:22 [pubmed] PHST- 2026/05/02 11:07 [entrez] PHST- 2026/05/02 00:00 [pmc-release] AID - 10.1007/s12020-026-04632-5 [pii] AID - 4632 [pii] AID - 10.1007/s12020-026-04632-5 [doi] PST - epublish SO - Endocrine. 2026 May 2;91(1):162. doi: 10.1007/s12020-026-04632-5. PMID- 42068456 OWN - NLM STAT- Publisher LR - 20260502 IS - 1573-2606 (Electronic) IS - 1389-9155 (Linking) DP - 2026 May 2 TI - Harnessing food cue evoked neuroimaging towards treatment optimisation for obesity and binge eating disorder. LID - 10.1007/s11154-026-10045-6 [doi] AB - Obesity and binge eating disorder (BED) are global health concerns that share overlapping neural mechanisms. These include alterations in the brain's reward and control systems leading to heightened sensitivity to food cues and impaired self-regulation, which underpin overeating. Identifying neuroimaging-based biomarkers that index these mechanisms could advance individualised treatments. This scoping review examined evidence on fMRI food cue reactivity as a potential approach for developing predictive and response biomarkers relevant to the treatment of obesity and BED. A systematic search of MEDLINE, Scopus, PsycINFO, and Embase (to July 2025) identified 57 eligible studies incorporating fMRI cue reactivity measures in the context of pharmacological, surgical, psychological, and lifestyle interventions. Of these, 7 reported predictive outcomes only (6 for adults with obesity and 1 for children and adolescents with obesity), 41 reported response outcomes only (36 for adults with obesity, 3 for children and adolescents with obesity and 2 for adults with binge eating), and 9 reported both predictive and response outcomes (8 for adults with obesity and 1 for adults with binge eating). Across paradigms and intervention modalities, there was consistent involvement of reward (striatum, insula, orbitofrontal and ventromedial prefrontal cortex) and cognitive control regions (dorsolateral and dorsomedial prefrontal cortex) as response outcomes from successful treatment. Reductions in reward-system reactivity following interventions were consistently associated with improved clinical outcomes, supporting the potential of fMRI food cue reactivity as a candidate biomarker of treatment response. However, this finding is highly skewed towards obesity, given the limited number of studies that report results for BED (3 studies). Furthermore, consistent evidence for reliable predictive biomarkers was also limited, likely due to methodological variability and small sample sizes. Overall, this review supports the potential of response outcomes from fMRI food cue reactivity as an indicator of treatment efficacy in obesity and highlights the limited evidence in BED. We also emphasise the need for further standardisation of paradigms and biomarker validation efforts. CI - (c) 2026. The Author(s). FAU - Flanagan, Kayla AU - Flanagan K AUID- ORCID: 0009-0005-2971-5397 AD - Turner Institute for Brain and Mental Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia. FAU - Pacheco, Luiza Bonfim AU - Pacheco LB AUID- ORCID: 0009-0002-9481-8198 AD - Turner Institute for Brain and Mental Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia. FAU - Gao, Mengxia AU - Gao M AUID- ORCID: 0000-0003-3393-5497 AD - Turner Institute for Brain and Mental Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia. AD - School of Humanities and Social Science, The Chinese University of Hong Kong, Shenzhen (CUHK-Shenzhen), Guangdong, 518172, People's Republic of China. FAU - Verdejo-Garcia, Antonio AU - Verdejo-Garcia A AUID- ORCID: 0000-0001-8874-9339 AD - Turner Institute for Brain and Mental Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, 18 Innovation Walk, Clayton, VIC, 3800, Australia. Antonio.Verdejo@monash.edu. LA - eng PT - Journal Article PT - Review DEP - 20260502 PL - Germany TA - Rev Endocr Metab Disord JT - Reviews in endocrine & metabolic disorders JID - 100940588 SB - IM OTO - NOTNLM OT - Binge eating OT - Obesity OT - Predictive biomarkers OT - Response biomarkers OT - fMRI food cue reactivity COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/05/03 05:24 MHDA- 2026/05/03 05:24 CRDT- 2026/05/02 11:06 PHST- 2025/10/22 00:00 [received] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/05/03 05:24 [medline] PHST- 2026/05/03 05:24 [pubmed] PHST- 2026/05/02 11:06 [entrez] AID - 10.1007/s11154-026-10045-6 [pii] AID - 10.1007/s11154-026-10045-6 [doi] PST - aheadofprint SO - Rev Endocr Metab Disord. 2026 May 2. doi: 10.1007/s11154-026-10045-6. PMID- 42068285 OWN - NLM STAT- Publisher LR - 20261022 IS - 2047-945X (Electronic) IS - 0260-1060 (Print) IS - 0260-1060 (Linking) DP - 2026 May 2 TI - Nutrition security, diet quality, and food assistance program use among food insecure households with children: A cross-sectional analysis. PG - 2601060261445338 LID - 10.1177/02601060261445338 [doi] AB - BackgroundWhile food insecurity (FI) assesses household access to sufficient food, increasing attention is being paid to nutrition security (NS), the ability to obtain health-promoting foods.AimThis cross-sectional analysis examined differences in sociodemographics, diet quality, and health status between food insecure families with low versus high NS and assessed if FI and NS severity was associated with food assistance program use.MethodsData were obtained from the 2023 Massachusetts Statewide Food Access Survey of >3000 adults. FI was assessed using the United States Department of Agriculture 18-item Household Food Security Module, NS via a validated four-item scale, and diet quality via the Prime Diet Quality Score (PDQS). FI and NS were analyzed as binary and continuous variables. Inferential statistics assessed group differences. Logistic regression assessed associations between the severity of FI and NS and food assistance program use.SummaryHouseholds with FI, >/=1 child ( 18 years old) presented lower scores (unstandardized beta coefficient [B] = -1.59; p = 0.006), as did those enrolled in non-health science degrees (B = -1.47; p = 0.005), single students (B =-1.40; p = 0.013), and those with a mental disorder (B = -2.79; p = 0.001). Heterosexual students scored higher than non-heterosexual peers (B = 2.49; p = 0.007), and students with normal weight showed better results than underweight participants (B = 2.08; p = 0.020). Domain-specific analyses revealed that males scored higher in physical activity, sleep, and social support, whereas females performed better in stress management. Students residing outside university accommodation generally achieved higher domain scores. CONCLUSIONS: These exploratory findings suggest that lifestyle, as measured by the U-SMILE, is associated with several sociodemographic and health-related characteristics in Spanish university students. Lower scores were associated with older age, enrolment in non-health science degrees, underweight status, non-heterosexual orientation, single marital status, and the presence of a diagnosed mental disorder. Sex, BMI status, accommodation, and employment status were associated with specific lifestyle domains. CI - (c) 2026. The Author(s). FAU - Mendoza-Munoz, Maria AU - Mendoza-Munoz M AD - Department of Education and Sport, Universidad Loyola Andalucia, Sevilla, Spain. FAU - Manzano-Carrasco, Samuel AU - Manzano-Carrasco S AD - Department of Education and Sport, Universidad Loyola Andalucia, Sevilla, Spain. FAU - Montenegro-Espinosa, Jose Adrian AU - Montenegro-Espinosa JA AD - Universidad Autonoma del Paraguay, Asuncion, Paraguay. FAU - Quiroz-Cardenas, Fiorella AU - Quiroz-Cardenas F AD - Universidad Politecnica y Artistica del Paraguay, Asuncion, Paraguay. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AD - Faculty Education and Social Sciences, Universidad Andres Bello, Vina del Mar, Chile. AD - Department of Sport Sciences, Fit Generation Research Institute, Andorra la Vella, Andorra. FAU - Olivares-Arancibia, Jorge AU - Olivares-Arancibia J AD - AFySE Group, Research in Physical Activity and School Health, School of Physical Education, Faculty of Education, Universidad de las Americas, Santiago, Chile. FAU - Yon, Dong Keon AU - Yon DK AD - Center for Digital Health, Medical Science Research Institute, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Precision Medicine, Kyung Hee University College of Medicine, Seoul, South Korea. AD - Department of Pediatrics, Kyung Hee University Medical Center, Kyung Hee University College of Medicine, Seoul, South Korea. FAU - Schuch, Felipe Barreto AU - Schuch FB AD - Psychiatry Institute, Federal University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil. AD - Department of Sports Methods and Techniques, Federal University of Santa Maria, Santa Maria, RS, Brazil. AD - Faculty of Health Sciences, Universidad Autonoma de Chile, Providencia, Chile. FAU - Galan-Lopez, Pablo AU - Galan-Lopez P AD - Department of Education and Sport, Universidad Loyola Andalucia, Sevilla, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Ecuador. josefranciscolopezgil@gmail.com. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno, Chile. josefranciscolopezgil@gmail.com. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260501 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Spain/epidemiology MH - Universities MH - Male MH - Cross-Sectional Studies MH - *Students/statistics & numerical data/psychology MH - *Life Style MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - Adult MH - *Health Behavior MH - Socioeconomic Factors PMC - PMC13285052 OTO - NOTNLM OT - College students OT - Lifestyle behaviors OT - Nutrition OT - Physical activity OT - Sleep OT - Spain COIS- Declarations. Ethics approval and consent to participate: The study protocol received ethical approval from the Research Ethics Committee of Universidad Loyola Andalucia (Approval ID: 240605/CE24544). The participants provided written consent. All methods procedures were carried out in accordance with Declaration of Helsinki. All participants were informed about the purpose of the study, assured of confidentiality, and provided written consent prior to participation. Participation was voluntary, and respondents could withdraw at any time without consequence. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/02 00:33 MHDA- 2026/06/22 13:44 PMCR- 2026/05/01 CRDT- 2026/05/01 23:26 PHST- 2026/02/23 00:00 [received] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/06/22 13:44 [medline] PHST- 2026/05/02 00:33 [pubmed] PHST- 2026/05/01 23:26 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 10.1186/s12889-026-27518-7 [pii] AID - 27518 [pii] AID - 10.1186/s12889-026-27518-7 [doi] PST - epublish SO - BMC Public Health. 2026 May 1;26(1):1937. doi: 10.1186/s12889-026-27518-7. PMID- 42067732 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260922 IS - 1931-7565 (Electronic) IS - 1931-7557 (Print) IS - 1931-7557 (Linking) VI - 20 IP - 3 DP - 2026 May 2 TI - Subregional hypothalamic volumes associate with childhood conduct problems in healthy adults. LID - 10.1007/s11682-026-01154-6 [doi] LID - 85 AB - Childhood conduct problems have been linked to alterations in frontolimbic circuits, yet the contribution of hypothalamic subregions remains largely unexplored. This study examined whether hypothalamic morphometry relates to conduct problems in 600 healthy young adults from the Human Connectome Project (206 with and 394 without conduct problems). Volumes of twelve hypothalamic subregions were extracted from structural MRI using the automated FreeSurfer segmentation. Group differences were assessed with linear models, and multivariable associations were tested with logistic regression adjusted for age, sex, and intracranial volume. Influential observations were screened using Cook's distance, and predictor importance was further evaluated through logistic LASSO regression with tenfold cross-validation. Individuals with a history of conduct problems showed larger volumes in anterior and tubular hypothalamic subregions-specifically the left anterior-inferior, left tubular-inferior, and right tubular-superior-while an initial inverse association in the left posterior subregion was no longer significant after excluding influential cases. These findings identify distinct hypothalamic subregions as structural correlates of early behavioral dysregulation and suggest that hypothalamic morphometry may reflect neurodevelopmental adaptations associated with childhood conduct problems. CI - (c) 2026. The Author(s). FAU - Pelagi, Assunta AU - Pelagi A AD - Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, 88100, Italy. FAU - Camastra, Chiara AU - Camastra C AD - Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, 88100, Italy. FAU - Quattrone, Andrea AU - Quattrone A AD - Neuroscience Research Center, Magna Graecia University, Catanzaro, 88100, Italy. AD - Institute of Neurology, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, 88100, Italy. FAU - Sarica, Alessia AU - Sarica A AD - Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, 88100, Italy. sarica@unicz.it. AD - Neuroscience Research Center, Magna Graecia University, Catanzaro, 88100, Italy. sarica@unicz.it. LA - eng GR - U54 MH091657/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20260502 PL - United States TA - Brain Imaging Behav JT - Brain imaging and behavior JID - 101300405 SB - IM MH - Humans MH - Female MH - *Hypothalamus/diagnostic imaging/pathology MH - Male MH - Magnetic Resonance Imaging/methods MH - Young Adult MH - Adult MH - *Conduct Disorder/diagnostic imaging/pathology MH - Organ Size MH - Child MH - Connectome MH - Adolescent PMC - PMC13135012 OTO - NOTNLM OT - Childhood conduct problems OT - Conduct disorder OT - Hypothalamus subunits OT - Logistic regression OT - MRI COIS- Ethics approval: This study used de-identified data from the Human Connectome Project; no new data were collected. According to journal policy, analyses of publicly available, de-identified datasets are exempt from institutional review. Use of HCP data complied with the HCP data-use terms. Consent to participate: Not applicable (secondary analysis of de-identified data). Consent for publication: Not applicable (secondary analysis of de-identified data). Competing interests: The authors declare no competing interests. EDAT- 2026/05/02 00:33 MHDA- 2026/05/02 00:34 PMCR- 2026/05/02 CRDT- 2026/05/01 23:19 PHST- 2025/10/31 00:00 [received] PHST- 2026/04/23 00:00 [accepted] PHST- 2026/05/02 00:34 [medline] PHST- 2026/05/02 00:33 [pubmed] PHST- 2026/05/01 23:19 [entrez] PHST- 2026/05/02 00:00 [pmc-release] AID - 10.1007/s11682-026-01154-6 [pii] AID - 1154 [pii] AID - 10.1007/s11682-026-01154-6 [doi] PST - epublish SO - Brain Imaging Behav. 2026 May 2;20(3):85. doi: 10.1007/s11682-026-01154-6. PMID- 42067530 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 2052-4463 (Electronic) IS - 2052-4463 (Linking) VI - 13 IP - 1 DP - 2026 May 1 TI - EED-Astig: A Multimodal Dataset for Pediatric Astigmatism Severity Prediction. LID - 10.1038/s41597-026-07330-z [doi] LID - 993 AB - Astigmatism is a prevalent refractive error in preschool children and a leading cause of preventable early visual impairment. Conventional screening methods are often unsuitable for young children due to high costs, specialized equipment, and the need for active cooperation. To address these challenges, we present EED-Astig, a multimodal pediatric dataset for artificial intelligence based astigmatism severity prediction. The dataset comprises periocular images from 640 children aged 3-6 years, acquired with smartphones under standardized conditions, with expert-verified annotations of corneal masks and anatomical landmarks. From these, we derive six clinically relevant structural parameters, including corneal exposure ratio and eyelash orientation, that are physiologically linked to astigmatism. In addition, behavioral and demographic metadata (e.g., screen time, birth history) provide complementary predictors for supervised learning. A semi-automated annotation pipeline based on the Segment Anything Model (SAM) ensures labeling consistency and quality. Technical validation demonstrates robust performance in keypoint detection and image segmentation, supporting the development of interpretable and scalable AI tools for pediatric eye health, particularly in low-resource settings. CI - (c) 2026. The Author(s). FAU - Liu, Haihua AU - Liu H AD - Department of Ophthalmology Center, Peking University First Hospital, Beijing, 100034, China. FAU - Li, Shengyang AU - Li S AD - Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences, Beijing, 100094, China. shyli@csu.ac.cn. AD - University of Chinese Academy of Sciences, Beijing, 100049, China. shyli@csu.ac.cn. FAU - Lv, Yixuan AU - Lv Y AUID- ORCID: 0000-0002-9007-3822 AD - Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences, Beijing, 100094, China. lvyixuan@csu.ac.cn. FAU - Liu, Rongjun AU - Liu R AD - Department of Ophthalmology Center, Peking University First Hospital, Beijing, 100034, China. FAU - Hou, Xinlin AU - Hou X AD - Department of Ophthalmology Center, Peking University First Hospital, Beijing, 100034, China. FAU - Chen, Furui AU - Chen F AD - Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences, Beijing, 100094, China. AD - University of Chinese Academy of Sciences, Beijing, 100049, China. FAU - Liu, Yuxuan AU - Liu Y AD - Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences, Beijing, 100094, China. AD - University of Chinese Academy of Sciences, Beijing, 100049, China. FAU - You, Jianing AU - You J AD - Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences, Beijing, 100094, China. AD - University of Chinese Academy of Sciences, Beijing, 100049, China. FAU - Wang, Han AU - Wang H AD - Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences, Beijing, 100094, China. AD - University of Chinese Academy of Sciences, Beijing, 100049, China. FAU - Liu, Silei AU - Liu S AD - Technology and Engineering Center for Space Utilization, Chinese Academy of Sciences, Beijing, 100094, China. AD - University of Chinese Academy of Sciences, Beijing, 100049, China. LA - eng PT - Dataset PT - Journal Article DEP - 20260501 PL - England TA - Sci Data JT - Scientific data JID - 101640192 SB - IM MH - Humans MH - *Astigmatism/diagnosis MH - Child, Preschool MH - Child MH - Artificial Intelligence PMC - PMC13338130 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/05/02 00:33 MHDA- 2026/07/07 12:34 PMCR- 2026/05/01 CRDT- 2026/05/01 23:14 PHST- 2025/10/01 00:00 [received] PHST- 2026/04/22 00:00 [accepted] PHST- 2026/07/07 12:34 [medline] PHST- 2026/05/02 00:33 [pubmed] PHST- 2026/05/01 23:14 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 10.1038/s41597-026-07330-z [pii] AID - 7330 [pii] AID - 10.1038/s41597-026-07330-z [doi] PST - epublish SO - Sci Data. 2026 May 1;13(1):993. doi: 10.1038/s41597-026-07330-z. PMID- 42066905 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 1532-429X (Electronic) IS - 1097-6647 (Print) IS - 1097-6647 (Linking) VI - 28 IP - 1 DP - 2026 Summer TI - Fontan conduit cross-sectional area and relationship to exercise performance. PG - 102729 LID - S1097-6647(26)00047-5 [pii] LID - 10.1016/j.jocmr.2026.102729 [doi] LID - 102729 AB - BACKGROUND: The synthetic extracardiac (EC) Fontan conduit may become inadequate as patients grow, potentially limiting cardiovascular capacity. OBJECTIVE: To evaluate the relationship between EC-Fontan conduit cross-sectional area (CSA), indexed to body surface area (BSA), and exercise performance. METHODS: A cross-sectional analysis of data from the Fontan Outcomes Registry using Clinical Examinations (FORCE) registry was performed. Patients with EC-Fontan anatomy who underwent cardiovascular magnetic resonance imaging (CMR) and cardiopulmonary exercise testing (CPET) within 1 year of each other were analyzed. Median length-averaged and minimum Fontan CSAs were measured using three-dimensional (3D) segmentation and indexed to BSA. The primary outcome was percent predicted peak VO(2) (ppVO(2)) on maximal effort CPET. Multivariable linear regression models assessed associations between Fontan CSA/BSA and ppVO(2), adjusting for known predictors of ppVO(2) in Fontan patients. RESULTS: Of the 493 patients with an EC Fontan and with time-matched CMR and EST, 324 had technically adequate 3D imaging for Fontan conduit measurements and an appropriately documented maximal effort excercise stress test (EST). CMRs occurred at median age of 15 years old and median time of 11 years after Fontan surgery. The median length-averaged and minimum Fontan CSA were 268 mm(2) (IQR 227-309mm(2)) and 229 mm(2) (IQR 194-273mm(2)), respectively. After adjusting for known predictors of ppVO2 in Fontan patients, both minimum and length-averaged Fontan CSA/BSA were positively associated with ppVO2, such that each mm(2)/m(2) increase in minimum CSA/BSA was associated with a 0.08% increase in ppVO2 (p<0.001) or each mm(2)/m(2) increase length-averaged CSA/BSA was associated with a 0.07% increase in ppVO2 (p<0.001). Fontan CSA/BSA was not significantly associated with cardiac function measures at rest, including ejection fraction and cardiac output. CONCLUSION: Smaller EC-Fontan CSA/BSA is independently associated with reduced exercise capacity after controlling for other known predictors of exercise performance. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - O'Halloran, Conor P AU - O'Halloran CP AD - Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University, Chicago, IL, USA. Electronic address: cohalloran@luriechildrens.org. FAU - Alsaied, Tarek AU - Alsaied T AD - Heart Institute, UPMC Children's Hospital of Pittsburgh, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. FAU - Wang, Alan P AU - Wang AP AD - Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University, Chicago, IL, USA. FAU - Ward, Kendra AU - Ward K AD - Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University, Chicago, IL, USA. FAU - Laternser, Christina AU - Laternser C AD - Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University, Chicago, IL, USA. FAU - Files, Matthew D AU - Files MD AD - Division of Pediatric Cardiology, University of Washington School of Medicine, Seattle Children's Hospital, Seattle, Washington. FAU - Mines, Ellen AU - Mines E AD - Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University, Chicago, IL, USA. FAU - Lemley, Bethan A AU - Lemley BA AD - Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University, Chicago, IL, USA. FAU - Husain, Nazia AU - Husain N AD - Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University, Chicago, IL, USA. FAU - Desai, Lajja AU - Desai L AD - Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University, Chicago, IL, USA. FAU - Rathod, Rahul H AU - Rathod RH AD - Department of Cardiology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts, United States. FAU - Robinson, Joshua D AU - Robinson JD AD - Ann & Robert H. Lurie Children's Hospital of Chicago, Department of Pediatrics, Northwestern University, Chicago, IL, USA. CN - FORCE Investigators LA - eng PT - Journal Article DEP - 20260430 PL - England TA - J Cardiovasc Magn Reson JT - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance JID - 9815616 SB - IM MH - Humans MH - *Fontan Procedure/adverse effects/instrumentation MH - Cross-Sectional Studies MH - Female MH - *Heart Defects, Congenital/surgery/physiopathology/diagnostic imaging MH - Exercise Test MH - *Exercise Tolerance MH - Adolescent MH - Male MH - Predictive Value of Tests MH - Registries MH - Child MH - Treatment Outcome MH - Time Factors MH - Body Surface Area MH - Magnetic Resonance Imaging MH - United States MH - Oxygen Consumption MH - Prosthesis Design MH - Young Adult MH - Magnetic Resonance Imaging, Cine PMC - PMC13265425 OTO - NOTNLM OT - Cardiac magnetic resonance imaging OT - Exercise OT - Fontan COIS- Declaration of competing interests Drs. Alsaied, Files, and Rathod have research grant support from Mezzion Pharmaceuticals as PIs of the Fontan Udenafil Exercise Longitudinal Assessment-2 (FUEL-2) Trial (NCT # NCT05918211), Dr. Ward is a site PI for this trial. No other relevant conflicts. FIR - Aggarwal, M IR - Aggarwal M IRAD- Department of Pediatrics, St. Louis Children's Hospital, St. Louis, MO. FIR - Alsaied, T IR - Alsaied T IRAD- The Heart and Vascular Institute, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA. FIR - Dorfman, A L IR - Dorfman AL IRAD- Congenital Heart Center, CS Mott Children's Hospital, Ann Arbor, MI. FIR - Doshi, A IR - Doshi A IRAD- Department of Pediatric and Congenital Cardiology, John Hopkins Hospital, Baltimore, MD. FIR - Files, M D IR - Files MD IRAD- Division of Pediatric Cardiology, Seattle Children's Hospital, Seattle, WA. FIR - Fogel, M IR - Fogel M IRAD- Division of Cardiology, The Children's Hospital of Philadelphia, Pennsylvania, PA. FIR - Hegde, S IR - Hegde S IRAD- Division of Pediatric Cardiology, Rady Children's Hospital, San Diego, CA. FIR - Hoyer, A IR - Hoyer A IRAD- Division of Pediatric Cardiology, University of Arizona, Tucson, AZ. FIR - Johnson, T IR - Johnson T IRAD- Division of Pediatric Cardiology, Riley Hospital for Children, Indianapolis, IN. FIR - Krishnamurthy, R IR - Krishnamurthy R IRAD- Department of Radiology, Nationwide Children's Hospital, Columbus, OH. FIR - Lam, C Z IR - Lam CZ IRAD- Department of Diagnostic and Interventional Radiology, The Hospital for Sick Children, Toronto, Canada. FIR - Loke, Y IR - Loke Y IRAD- Division of Cardiology, Children's National Hospital, Washington DC. FIR - Marsden, A L IR - Marsden AL IRAD- Department of Bioengineering & Pediatrics, Stanford University, Palo Alto, CA. FIR - Muthurangu, V IR - Muthurangu V IRAD- UCL Centre for Cardiovascular Imaging, Institute of Cardiovascular Science, London, UK. FIR - Olivieri, L J IR - Olivieri LJ IRAD- The Heart and Vascular Institute, UPMC Children's Hospital of Pittsburgh, Pittsburgh, PA. FIR - Quail, M IR - Quail M IRAD- UCL Centre for Cardiovascular Imaging, Institute of Cardiovascular Science, London, UK. FIR - Raimondi, F IR - Raimondi F IRAD- Congenital Cardiology Unit, Ospedale Papa Giovanni XXIII, Bergamo, Italy. FIR - Ramachandran, P IR - Ramachandran P IRAD- Division of Pediatric Cardiology, University of Kentucky, Lexington, KY. FIR - Rathod, R H IR - Rathod RH IRAD- Department of Cardiology, Boston Children's Hospital, Boston, MA. FIR - Renella, P IR - Renella P IRAD- Division of Pediatric Cardiology, CHOC Children's Hospital, Orange, CA. FIR - Renno, M S IR - Renno MS IRAD- Division of Pediatric Cardiology, Arkansas Children's Hospital, Little Rock, AR. FIR - Robinson, J D IR - Robinson JD IRAD- Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital, Chicago, IL. FIR - Ruchira, G IR - Ruchira G IRAD- Division of Pediatric Cardiology, Cedars-Sinai Guerin Children's Hospital, Los Angeles, CA. FIR - Shah, A IR - Shah A IRAD- Division of Pediatric Cardiology, New York-Presbyterian Morgan Stanley Children's Hospital, New York, NY. FIR - Slesnick, T C IR - Slesnick TC IRAD- Division of Pediatric Cardiology, Children's Healthcare of Atlanta, Atlanta, GA. FIR - Soslow, J H IR - Soslow JH IRAD- Division of Pediatric Cardiology, Vanderbilt University Medical Center, Nashville, TN. FIR - Steele, J IR - Steele J IRAD- Division of Pediatric Cardiology, Yale New Haven Children's Hospital, New Haven, CT. FIR - Stern, K W IR - Stern KW IRAD- Division of Pediatric Cardiology, Mount Sinai Kravis Children's Hospital, New York, NY. FIR - Thattaliyath, B IR - Thattaliyath B IRAD- Division of Pediatric Cardiology, Stead Family Children's Hospital, Iowa City, IA. FIR - Vaikom House, A IR - Vaikom House A IRAD- Division of Pediatric Cardiology, Oklahoma Children's Hospital, Oklahoma City, OK. FIR - Weigand, J IR - Weigand J IRAD- Division of Pediatric Cardiology, Texas Children's Hospital, Houston, TX. EDAT- 2026/05/02 00:33 MHDA- 2026/06/15 11:30 PMCR- 2026/04/30 CRDT- 2026/05/01 19:12 PHST- 2025/11/24 00:00 [received] PHST- 2026/02/24 00:00 [revised] PHST- 2026/04/13 00:00 [accepted] PHST- 2026/06/15 11:30 [medline] PHST- 2026/05/02 00:33 [pubmed] PHST- 2026/05/01 19:12 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - S1097-6647(26)00047-5 [pii] AID - 102729 [pii] AID - 10.1016/j.jocmr.2026.102729 [doi] PST - ppublish SO - J Cardiovasc Magn Reson. 2026 Summer;28(1):102729. doi: 10.1016/j.jocmr.2026.102729. Epub 2026 Apr 30. PMID- 42066894 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260730 IS - 1531-5037 (Electronic) IS - 0022-3468 (Linking) VI - 61 IP - 8 DP - 2026 Aug TI - Staged controlled bowel expansion prior to serial transverse enteroplasty in preterm neonates with short bowel syndrome: A safe and feasible strategy to enable intestinal reconstruction. PG - 163172 LID - S0022-3468(26)00255-1 [pii] LID - 10.1016/j.jpedsurg.2026.163172 [doi] AB - BACKGROUND: Preterm neonates with short bowel syndrome represent one of the most challenging populations in pediatric intestinal rehabilitation. Autologous intestinal reconstruction is frequently delayed in this group because insufficient bowel dilation precludes safe lengthening, prolonging dependence on parenteral nutrition and increasing the risk of intestinal failure-associated liver disease, sepsis, and growth failure. METHODS: We conducted a retrospective single-center cohort study of preterm neonates with short bowel syndrome managed with a standardized protocol of controlled bowel expansion (CBE) followed by serial transverse enteroplasty (STEP) between 2018 and 2025. Eligible patients had pediatric intestinal failure requiring parenteral nutrition for >/=60 consecutive days. Primary outcomes were bowel length gain and achievement of enteral autonomy. Secondary outcomes included complications and resolution of intestinal failure-associated liver disease (IFALD). RESULTS: Nine preterm neonates were included (median gestational age 27 weeks [IQR, 25-28]; median birth weight 880 g [IQR, 820-1080]; underlying aetiology predominantly necrotizing enterocolitis [78%]). Baseline bowel length was a median of 33 cm (18% of expected for gestational age). During the CBE phase, bowel length increased by a median of 20 cm (IQR, 14.5-30), allowing progression to definitive STEP after a median expansion period of 27 weeks (IQR, 18.1-33). STEP provided an additional median gain of 20 cm (IQR, 14-40), with a cumulative median gain of 54.5 cm (IQR, 42-61) and a final bowel length of 61% of expected. Eight of nine patients (88%) achieved full enteral autonomy at a median of 29.3 weeks post-STEP (IQR, 24.1-52.5). IFALD resolved in all affected patients, and no mortality or post-STEP surgical complications occurred. CONCLUSIONS: In preterm neonates with short bowel syndrome, CBE was incorporated as part of a staged surgical pathway prior to STEP, during which bowel length increased. This approach was feasible and was associated with progression to STEP, with high rates of enteral autonomy observed in the cohort. These findings suggest that CBE may serve as a preconditioning strategy to enable timely reconstruction in a population traditionally considered unsuitable for early lengthening. Prospective multicentre studies are warranted to validate these outcomes and standardize patient selection. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Mammoo, Saleem AU - Mammoo S AD - General and Thoracic Surgery Department, Sidra Medicine, 26999, Doha, Qatar. FAU - Alshahwani, Noora AU - Alshahwani N AD - General and Thoracic Surgery Department, Sidra Medicine, 26999, Doha, Qatar. Electronic address: nalshahwani@sidra.org. FAU - Mancha, Maraeh Angela AU - Mancha MA AD - General and Thoracic Surgery Department, Sidra Medicine, 26999, Doha, Qatar. Electronic address: mmancha@sidra.org. FAU - Ali, Mansour AU - Ali M AD - General and Thoracic Surgery Department, Sidra Medicine, 26999, Doha, Qatar. FAU - Baghazal, Hassan AU - Baghazal H AD - General and Thoracic Surgery Department, Sidra Medicine, 26999, Doha, Qatar. FAU - Brisseau, Guy AU - Brisseau G AD - General and Thoracic Surgery Department, Sidra Medicine, 26999, Doha, Qatar. FAU - Khalil, Basem AU - Khalil B AD - King's College Hospital London, UAE. LA - eng PT - Journal Article DEP - 20260429 PL - United States TA - J Pediatr Surg JT - Journal of pediatric surgery JID - 0052631 SB - IM MH - Humans MH - *Short Bowel Syndrome/surgery MH - Infant, Newborn MH - Retrospective Studies MH - Male MH - Infant, Premature MH - Feasibility Studies MH - Female MH - *Infant, Premature, Diseases/surgery MH - *Tissue Expansion/methods MH - *Digestive System Surgical Procedures/methods MH - *Plastic Surgery Procedures/methods MH - Treatment Outcome MH - Parenteral Nutrition MH - Intestinal Failure OTO - NOTNLM OT - Controlled bowel expansion OT - Enteral autonomy OT - Intestinal failure OT - Intestinal failure-associated liver disease OT - Intestinal rehabilitation OT - Neonatal surgery OT - Pediatric surgery OT - Preterm neonates OT - Serial transverse enteroplasty OT - Short bowel syndrome COIS- Conflicts of interest None of the authors listed have any conflicts of interest. EDAT- 2026/05/02 00:33 MHDA- 2026/07/31 00:38 CRDT- 2026/05/01 19:12 PHST- 2026/01/11 00:00 [received] PHST- 2026/04/16 00:00 [revised] PHST- 2026/04/24 00:00 [accepted] PHST- 2026/07/31 00:38 [medline] PHST- 2026/05/02 00:33 [pubmed] PHST- 2026/05/01 19:12 [entrez] AID - S0022-3468(26)00255-1 [pii] AID - 10.1016/j.jpedsurg.2026.163172 [doi] PST - ppublish SO - J Pediatr Surg. 2026 Aug;61(8):163172. doi: 10.1016/j.jpedsurg.2026.163172. Epub 2026 Apr 29. PMID- 42066635 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260716 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 148 DP - 2026 Aug TI - Specific Nutrition Evaluation for Advanced Chronic Liver Disease: Validation through psychometrics analysis. PG - 113211 LID - S0899-9007(26)00119-X [pii] LID - 10.1016/j.nut.2026.113211 [doi] AB - OBJECTIVES: Validated instruments specifically designed to assess the nutritional status of individuals with chronic liver disease (CLD) are scarce. The purpose of this study was to evaluate the psychometric properties of the Specific Nutrition Evaluation for Advanced Chronic Liver Disease (SNE-ACLD) instrument and establish cut-off points for the nutritional assessment of individuals with CLD. METHODS: Hospitalized individuals with CLD were evaluated by SNE-ACLD and different nutritional assessment tools. Initial evidence of structural construct validity was assessed using principal component analysis; reliability using Cronbach's alpha; cut-off points were determined using cluster analysis. Criterion validity, in which the appendicular muscle mass index was adopted as a reference for concurrent validity using ROC curve; and Cox regression to assess the one-year mortality risk for predictive validity. RESULTS: Two hundred participants were evaluated, of which 75.0% were male, 50.5% were elderly, and 80.8% were classified as Child-Pugh B or C. Principal component analysis demonstrated that SNE-ACLD has four components that explain 69.9% of the total variance of the construct. Cronbach's alpha of 0.70 indicated a good interrelationship between the items. The established cut-off points classified the participants into four groups: without malnutrition, mild, moderate, or severe malnutrition. The SNE-ACLD showed concurrent validity with an AUC of 0.714 and predictive validity, with severely malnourished participants presenting one-year mortality risk almost five times higher (HR = 4.98; 95% CI: 2.42-10.2) than those without severe malnutrition. CONCLUSIONS: SNE-ACLD effectively addresses the domains of the malnutrition construct in this public, presenting evidence of both internal and external validity. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Arruda, Monalisa Reis AU - Arruda MR AD - Graduate Program in Food, Nutrition and Health, Department of Nutrition, School of Nutrition, Federal University of Bahia, Salvador, Bahia, Brazil. Electronic address: monalisa.arruda@ufba.br. FAU - Cunha, Carla de Magalhaes AU - Cunha CM AD - Graduate Program in Food, Nutrition and Health, Department of Nutrition, School of Nutrition, Federal University of Bahia, Salvador, Bahia, Brazil. FAU - Batista, Ana Clara Vital AU - Batista ACV AD - Graduate Program in Food, Nutrition and Health, Department of Nutrition, School of Nutrition, Federal University of Bahia, Salvador, Bahia, Brazil. FAU - Boulhosa, Ramona Souza da Silva Baqueiro AU - Boulhosa RSDSB AD - Graduate Program in Food, Nutrition and Health, Department of Nutrition, School of Nutrition, Federal University of Bahia, Salvador, Bahia, Brazil. FAU - Garcez, Lais Spindola AU - Garcez LS AD - Graduate Program in Food, Nutrition and Health, Department of Nutrition, School of Nutrition, Federal University of Bahia, Salvador, Bahia, Brazil. FAU - Lyra, Andre Castro AU - Lyra AC AD - Graduate Program in Medicine and Health, Department of Medicine, Faculty of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil. FAU - Romeiro, Fernando Gomes AU - Romeiro FG AD - Graduate Program in Pathophysiology in Internal Medicine, Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University, Botucatu, Sao Paulo, Brazil. FAU - Pereira, Ketlin Gianini AU - Pereira KG AD - Graduate Program in Pathophysiology in Internal Medicine, Department of Internal Medicine, Botucatu Medical School, Sao Paulo State University, Botucatu, Sao Paulo, Brazil. FAU - Cavalcante, Lourianne Nascimento AU - Cavalcante LN AD - Graduate Program in Medicine and Health, Department of Medicine, Faculty of Medicine, Federal University of Bahia, Salvador, Bahia, Brazil. FAU - de Jesus, Rosangela Passos AU - de Jesus RP AD - Graduate Program in Food, Nutrition and Health, Department of Nutrition, School of Nutrition, Federal University of Bahia, Salvador, Bahia, Brazil. FAU - de Oliveira, Lucivalda Pereira Magalhaes AU - de Oliveira LPM AD - Graduate Program in Food, Nutrition and Health, Department of Nutrition, School of Nutrition, Federal University of Bahia, Salvador, Bahia, Brazil. LA - eng PT - Journal Article PT - Validation Study DEP - 20260317 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Humans MH - Male MH - *Nutrition Assessment MH - Female MH - Reproducibility of Results MH - *Psychometrics MH - *Nutritional Status MH - *Liver Diseases/complications MH - Middle Aged MH - Chronic Disease MH - Aged MH - *Malnutrition/diagnosis MH - Principal Component Analysis MH - Adult MH - ROC Curve OTO - NOTNLM OT - Chronic liver disease OT - Instruments OT - Malnutrition OT - Nutritional assessment OT - Psychometrics COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/02 00:33 MHDA- 2026/05/17 06:29 CRDT- 2026/05/01 18:07 PHST- 2025/11/28 00:00 [received] PHST- 2026/02/03 00:00 [revised] PHST- 2026/03/15 00:00 [accepted] PHST- 2026/05/17 06:29 [medline] PHST- 2026/05/02 00:33 [pubmed] PHST- 2026/05/01 18:07 [entrez] AID - S0899-9007(26)00119-X [pii] AID - 10.1016/j.nut.2026.113211 [doi] PST - ppublish SO - Nutrition. 2026 Aug;148:113211. doi: 10.1016/j.nut.2026.113211. Epub 2026 Mar 17. PMID- 42066625 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260828 IS - 1879-2219 (Electronic) IS - 0966-6362 (Linking) VI - 128 DP - 2026 Jul TI - Data-based evidence of normative gait in healthy adults (18-65 years): Demographics, methodology, and data availability-A scoping review. PG - 110176 LID - S0966-6362(26)00086-X [pii] LID - 10.1016/j.gaitpost.2026.110176 [doi] AB - BACKGROUND: Normative gait data are essential for research, identifying abnormalities and guiding diagnosis. However, a systematic overview of normative gait data and their characteristics, independent of measurement systems and parameter types, is currently lacking. OBJECTIVE: This study aims to summarize the current state of normative gait data for healthy adults, focusing on population characteristics, data descriptions, measurement systems, research/data gaps, data presentation and accessibility. METHODOLOGY: Databases including Medline, ScienceDirect, Cochrane Library, and Embase were searched, supplemented by studies referenced in prior reviews. Inclusion criteria were studies on healthy adults (18-65 years) with normative gait data and a population size of at least 30. Secondary data analyses were excluded. RESULTS AND DISCUSSION: 105 studies, involving 11764 participants, were included. Open access publications accounted for 54.2%, with 22 studies providing additional data links. Data stratified by age and sex was reported in 50.5% and 49.5% of studies, respectively, while 64.8% documented footwear. Multi-camera systems were most frequently used in publications, while IMUs (Inertial Measurement Units) captured data from the most participants. The dataset is available to facilitate further customized analyses of normative gait data. CONCLUSION: Although the availability and accessibility of normative gait data have improved in recent years, substantial challenges remain due to the lack of standardization. Future efforts should focus on enhancing data descriptions, encouraging independent reproduction, and defining standards to improve reproducibility and usability for machine learning applications. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Kreusch, Richard AU - Kreusch R AD - University of Applied Sciences Jena, Carl-Zeiss-Promenade 2, 07745 Jena, Thuringen, Germany. Electronic address: Richard.Kreusch@eah-jena.de. FAU - Gross, Catharina Sophia AU - Gross CS AD - University of Applied Sciences Jena, Carl-Zeiss-Promenade 2, 07745 Jena, Thuringen, Germany. FAU - Saal, Susanne AU - Saal S AD - University of Applied Sciences Jena, Carl-Zeiss-Promenade 2, 07745 Jena, Thuringen, Germany. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Scoping Review DEP - 20260420 PL - England TA - Gait Posture JT - Gait & posture JID - 9416830 SB - IM MH - Humans MH - *Gait/physiology MH - Adult MH - Middle Aged MH - Reference Values MH - Adolescent MH - Aged MH - Male MH - Female MH - Young Adult MH - Gait Analysis OTO - NOTNLM OT - Dataset OT - Gait OT - Gait parameter OT - Healthy adults OT - Normative OT - Reference data OT - Scoping review COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/02 00:33 MHDA- 2026/05/16 00:36 CRDT- 2026/05/01 18:07 PHST- 2025/03/13 00:00 [received] PHST- 2026/04/02 00:00 [revised] PHST- 2026/04/03 00:00 [accepted] PHST- 2026/05/16 00:36 [medline] PHST- 2026/05/02 00:33 [pubmed] PHST- 2026/05/01 18:07 [entrez] AID - S0966-6362(26)00086-X [pii] AID - 10.1016/j.gaitpost.2026.110176 [doi] PST - ppublish SO - Gait Posture. 2026 Jul;128:110176. doi: 10.1016/j.gaitpost.2026.110176. Epub 2026 Apr 20. PMID- 42066057 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261019 IS - 1539-2031 (Electronic) IS - 0192-0790 (Print) IS - 0192-0790 (Linking) VI - 60 IP - 10 DP - 2026 Nov-Dec 01 TI - The Management of Irritable Bowel Syndrome: A Position Paper of the Neurogastroenterology and Motility Section of the Israeli Gastroenterology Association. PG - 867-884 LID - 10.1097/MCG.0000000000002388 [doi] AB - Irritable bowel syndrome (IBS) is a disorder of gut-brain interaction with symptoms including abdominal pain associated with a change in stool form or frequency. IBS global prevalence is around 4% and its impact on patient's quality of life and social functioning is substantial. Multidisciplinary working teams of the Israeli Society of Neurogastroenterology and Motility evaluated all validated approaches to IBS management. The aim was to develop a national, evidence-based position document on IBS management for general practitioners and adult and pediatric gastroenterologists. This position document comprehensively reviewed therapeutic options, including patient education (including specific national communities), dietary modifications (particularly the low FODMAP diet), antispasmodic drugs, probiotics, antibiotics (eg, rifaximin), secretagogues (eg, linaclotide), neuromodulators, psychological therapies (including cognitive behavioral therapy and gut-directed hypnotherapy), and complementary medicine approaches. The importance of establishing a positive physician-patient communication with a therapeutic partnership, including an empathic approach and implementation of the bio-psycho-social model, was also strongly emphasized. A structured treatment algorithm incorporating multiple therapeutic tools that are locally available was developed as well. We hope that this position paper will provide a practical and updated tool for the management of IBS in Israel and in other countries as well. CI - Copyright (c) 2026 The Author(s). Published by Wolters Kluwer Health, LLC. FAU - Shibli, Fahmi AU - Shibli F AD - Institute of Gastroenterology and Liver Diseases, Ha'Em Medical Center, Afula. AD - Rappaport Faculty of Medicine. FAU - Dekel, Roy AU - Dekel R AD - Department of Gastroenterology and Hepatology, Sourasky Medical Center. FAU - Yishai, Ron AU - Yishai R AD - Department of Gastroenterology and Hepatology, Sourasky Medical Center. FAU - Lysy, Joseph AU - Lysy J AD - Department of Gastroenterology and Liver Diseases, Shaare Zedek Medical Center. FAU - Sperber, Ami AU - Sperber A AD - Faculty of Health Sciences. FAU - Bar, Nir AU - Bar N AD - Department of Gastroenterology and Hepatology, Sourasky Medical Center. FAU - Baruch, Ronnie AU - Baruch R AD - Department of Gastroenterology and Hepatology, Sourasky Medical Center. FAU - Frishman, Sigal AU - Frishman S AD - Clinical Dietitian, Rabin Medical Center, Beilenson Campus, Petah Tikva. FAU - Nevo Shor, Anat AU - Nevo Shor A AD - Department of Gastroenterology and Liver Diseases, Soroka Medical Center, Ben-Gurion University of the Negev, Beer Sheva. FAU - Hershkovici, Tiberiu AU - Hershkovici T AD - Department of Gastroenterology and Liver Diseases, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem. FAU - Thurm, Tamar AU - Thurm T AD - Department of Gastroenterology and Hepatology, Sourasky Medical Center. FAU - Mari, Amir AU - Mari A AD - Department of Gastroenterology, Nazareth EMMS Hospital, Nazareth. AD - Faculty of Medicine in the Galilee, Bar-Ilan University, Ramat Gan, Israel. FAU - Carter, Dan AU - Carter D AD - Department of Gastroenterology and Liver Diseases, Sheba Medical Center. FAU - Brun, Rita AU - Brun R AD - Department of Gastroenterology, Rambam Health Care Campus, Technion-Israel Institute of Technology, Haifa. FAU - Ishay, Yuval AU - Ishay Y AD - Department of Gastroenterology and Liver Diseases, Hadassah Medical Center, Hebrew University of Jerusalem, Jerusalem. FAU - Dickman, Ram AU - Dickman R AD - Division of Gastroenterology, Rabin Medical Center, Beilinson Campus, Tel Aviv University, Tel Aviv. LA - eng PT - Consensus Statement PT - Journal Article PT - Review DEP - 20260921 PL - United States TA - J Clin Gastroenterol JT - Journal of clinical gastroenterology JID - 7910017 SB - IM MH - Humans MH - FODMAP Diet MH - Gastroenterology/standards MH - *Irritable Bowel Syndrome/therapy/diagnosis MH - Israel MH - Quality of Life MH - Societies, Medical PMC - PMC13626592 OTO - NOTNLM OT - FODMAP OT - functional gastrointestinal disorders OT - irritable bowel syndrome OT - neuromodulation OT - psychotherapy OT - treatment algorithm COIS- The authors declare that they have nothing to disclose EDAT- 2026/05/01 18:45 MHDA- 2026/10/09 17:34 PMCR- 2026/09/30 CRDT- 2026/05/01 13:54 PHST- 2025/10/23 00:00 [received] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/10/09 17:34 [medline] PHST- 2026/05/01 18:45 [pubmed] PHST- 2026/05/01 13:54 [entrez] PHST- 2026/09/30 00:00 [pmc-release] AID - 00004836-990000000-00642 [pii] AID - JCG-D-25-01031 [pii] AID - 10.1097/MCG.0000000000002388 [doi] PST - ppublish SO - J Clin Gastroenterol. 2026 Nov-Dec 01;60(10):867-884. doi: 10.1097/MCG.0000000000002388. Epub 2026 Sep 21. PMID- 42065904 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260921 IS - 1613-9860 (Electronic) IS - 1869-6716 (Print) IS - 1613-9860 (Linking) VI - 16 IP - 1 DP - 2026 Jan 7 TI - mHealth to support resistance training using outdoor gyms: the ecofit hybrid type 3 implementation-effectiveness trial. LID - 10.1093/tbm/ibag024 [doi] LID - ibag024 AB - BACKGROUND: There is a need to scale up effective physical activity interventions among the general population, particularly those incorporating resistance training. Ecofit is a community-based, multicomponent intervention promoting resistance and aerobic physical activity through smartphone technology, the outdoor built environment, and social support. This study aimed to scale up ecofit by comparing Low versus Moderate implementation support on the reach (outdoor gym use) of ecofit within two large regional municipalities. METHODS: A hybrid type 3 implementation-effectiveness trial was conducted across two large municipalities in eastern Australia. Outdoor gyms (n = 18) were randomized to Low (ecofit app only) or Moderate [ecofit app, QR (quick response) codes on equipment, face-to-face workout sessions] implementation support. The primary outcome of "reach" was defined as the baseline-adjusted difference in the number of outdoor gym users (i.e. adults using outdoor gym equipment for resistance training) between groups. Reach was measured at baseline and 3-month follow-up using a modified System for Observing Play and Recreation in Communities tool, with blinded assessors observing community members perceived to be >/=18 years [categorized as Adults (aged 18-59) or Seniors (aged >/=60)]. Secondary outcomes included app uptake, dose received, implementation fidelity, and acceptability, feasibility, and dose-satisfaction regarding the app and guided sessions. RESULTS: There was no significant difference in people using outdoor gym equipment for resistance training between Low and Moderate support groups at 3-month follow-up [incidence rate ratio (IRR) = 1.68, 95% CI: 0.96-2.94]. Among adults (aged 18-59), the Moderate support group showed significantly higher outdoor gym use at follow-up (IRR = 1.83, 95% CI: 1.01-3.31) compared to the Low support group. Over 6 months, 1273 users registered for the app, completing 503 workouts, 62% of which occurred indoors. CONCLUSIONS: Ecofit shows promise for promoting resistance training, particularly among adults. Broader marketing and enhanced engagement strategies may be required to increase outdoor gym use and sustain participation over time. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Society of Behavioral Medicine. FAU - Plotnikoff, Ronald C AU - Plotnikoff RC AUID- ORCID: 0000-0002-3763-8273 AD - Global Sport and Movement Collaborative, University of Newcastle, Callaghan, NSW, 2308, Australia. AD - Global Sport and Movement Collaborative, Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. FAU - Jansson, Anna K AU - Jansson AK AUID- ORCID: 0000-0001-9039-2033 AD - School of Heath Sciences, University of Newcastle, Callaghan, NSW, 2308, Australia. AD - Food and Nutrition Program, Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. FAU - Duncan, Mitch J AU - Duncan MJ AUID- ORCID: 0000-0002-9166-6195 AD - Global Sport and Movement Collaborative, University of Newcastle, Callaghan, NSW, 2308, Australia. AD - Global Sport and Movement Collaborative, Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - School of Medicine & Public Health, University of Newcastle, Callaghan, NSW, 2308, Australia. FAU - Beacroft, Sam AU - Beacroft S AUID- ORCID: 0009-0005-5821-9800 AD - Global Sport and Movement Collaborative, University of Newcastle, Callaghan, NSW, 2308, Australia. AD - Global Sport and Movement Collaborative, Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. FAU - Bauman, Adrian AU - Bauman A AUID- ORCID: 0000-0002-0369-4621 AD - School of Public Health, University of Sydney, Camperdown, NSW, 2006, Australia. FAU - Attia, John AU - Attia J AUID- ORCID: 0000-0001-9800-1308 AD - School of Medicine & Public Health, University of Newcastle, Callaghan, NSW, 2308, Australia. FAU - Cox, Emily R AU - Cox ER AUID- ORCID: 0000-0002-1687-3522 AD - Global Sport and Movement Collaborative, University of Newcastle, Callaghan, NSW, 2308, Australia. AD - Global Sport and Movement Collaborative, Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - School of Exercise & Nutrition Sciences, Queensland University of Technology, Kelvin Grove, QLD, 4059, Australia. FAU - Smith, Jordan J AU - Smith JJ AUID- ORCID: 0000-0003-4640-8645 AD - Global Sport and Movement Collaborative, University of Newcastle, Callaghan, NSW, 2308, Australia. AD - Global Sport and Movement Collaborative, Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. FAU - Robards, Sara L AU - Robards SL AD - Global Sport and Movement Collaborative, University of Newcastle, Callaghan, NSW, 2308, Australia. FAU - Babic, Mark AU - Babic M AUID- ORCID: 0009-0002-4635-4405 AD - Global Sport and Movement Collaborative, University of Newcastle, Callaghan, NSW, 2308, Australia. AD - Global Sport and Movement Collaborative, Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. FAU - Lubans, David R AU - Lubans DR AUID- ORCID: 0000-0002-0204-8257 AD - Global Sport and Movement Collaborative, University of Newcastle, Callaghan, NSW, 2308, Australia. AD - Global Sport and Movement Collaborative, Hunter Medical Research Institute, New Lambton Heights, NSW, 2305, Australia. AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. LA - eng GR - APP1134914/National Health and Medical Research Council of Australia/ PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Transl Behav Med JT - Translational behavioral medicine JID - 101554668 SB - IM MH - Humans MH - *Resistance Training/methods MH - Female MH - Adult MH - Male MH - Middle Aged MH - *Mobile Applications MH - *Exercise MH - *Health Promotion/methods MH - Australia MH - Adolescent MH - Young Adult MH - *Fitness Centers MH - Smartphone PMC - PMC13134382 OAB - Outdoor gyms are increasingly installed in parks to encourage free, accessible exercise, yet they are often underused. We implemented the ecofit intervention, a free mobile app designed to help people use outdoor gyms for resistance and aerobic exercise, across two large regional municipalities in Australia. The app includes predesigned workouts, instructional videos, customizable options, and self-monitoring tools. We compared two levels of implementation support: nine gyms received Low support (ecofit app only), while another nine received Moderate support [ecofit app, QR (quick response) codes on equipment, and three cost-free group workouts led by an exercise professional]. The main aim was to compare the number of people using outdoor gyms receiving Low and Moderate support at baseline and 3 months. There was no significant difference in overall outdoor gym use between the Low and Moderate support groups. However, more adults under 60 used outdoor gyms with Moderate support compared to Low support at follow-up. Over 6 months, more than 1200 people registered for the app and completed 503 workouts. Users found the app easy to use and motivating, though many preferred private settings for exercise. Ecofit shows promise for promoting resistance training using outdoor gyms. Future studies should incorporate broader marketing and collaborate with municipal councils and local government agencies to improve engagement and accessibility. OABL- eng OTO - NOTNLM OT - implementation OT - outdoor gym OT - physical activity OT - resistance training COIS- All authors declare that they have no conflicts of interest. EDAT- 2026/05/01 12:37 MHDA- 2026/05/01 12:38 PMCR- 2026/05/01 CRDT- 2026/05/01 11:40 PHST- 2026/05/01 12:38 [medline] PHST- 2026/05/01 12:37 [pubmed] PHST- 2026/05/01 11:40 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 8666280 [pii] AID - ibag024 [pii] AID - 10.1093/tbm/ibag024 [doi] PST - ppublish SO - Transl Behav Med. 2026 Jan 7;16(1):ibag024. doi: 10.1093/tbm/ibag024. PMID- 42065851 OWN - NLM STAT- MEDLINE DCOM- 20260519 LR - 20261010 IS - 0975-0711 (Electronic) IS - 0254-8860 (Linking) VI - 45 IP - 3 DP - 2026 Jun TI - Exclusive enteral nutrition for induction of remission in Crohn's disease in adults: A systematic review and meta-analysis of randomized trials and real-world studies. PG - 452-473 LID - 10.1007/s12664-026-01989-3 [doi] AB - BACKGROUND: Exclusive enteral nutrition (EEN) is an established induction therapy in pediatric Crohn's disease (CD); however, its role in adults remains less well defined. METHODS: A systematic search was performed through December 2025. Eligible studies included randomized controlled trials (RCTs) and non-randomized studies evaluating EEN in adults (>/= 18 years) with active CD. The primary outcome was clinical remission, defined by validated disease activity indices. Risk of bias was assessed using RoB 2 and the Newcastle-Ottawa Scale. Random-effects models were applied to estimate pooled remission rates and relative risks. RESULTS: Forty studies, comprising 2459 patients, were included. In 23 real-world cohort studies (n = 1269), the pooled clinical remission rate with EEN was 66% (95% CI = 0.60-0.71, I(2) = 69.9%, p < 0.0001). In five RCTs (n = 315) comparing corticosteroids with EEN, corticosteroids achieved higher remission rates compared with EEN (RR 0.65, 95% CI = 0.50-0.84; p = 0.0009). In eight RCTs (n = 301), remission rates did not differ significantly between elemental and non-elemental formulations (RR 1.04, 95% CI = 0.88-1.23). Sub-group analyses by protein type and lipid composition showed no differences in efficacy. In two studies, combination therapy with biologics plus EEN was associated with a higher clinical remission compared with biologics alone (RR 0.75; 95% CI = 0.67-0.84; p < 0.0001). Adverse events were generally mild, with poor palatability being most frequent. CONCLUSION: EEN induces clinical remission in adults with CD. It is less efficacious than corticosteroids to induce clinical remission. The efficacy of EEN is independent of formula composition. Given its favorable safety profile, EEN may represent a therapeutic option in select adult patients. PROSPERO registration number: CRD42023445039. CI - (c) 2026. Indian Society of Gastroenterology. FAU - Kaur, Kirandeep AU - Kaur K AUID- ORCID: 0000-0001-8530-9493 AD - Department of Pharmacology, Dayanand Medical College and Hospital, Ludhiana, 141 001, India. FAU - Singh, Arshdeep AU - Singh A AUID- ORCID: 0000-0001-7163-0454 AD - Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, 141 001, India. FAU - Kaur, Simrat AU - Kaur S AUID- ORCID: 0009-0004-5238-2255 AD - Department of Pharmacology, Dr. B R Ambedkar State Institute of Medical Sciences, Sahibzada Ajit Singh Nagar, 160 055, Punjab, India. FAU - Sharma, Riya AU - Sharma R AUID- ORCID: 0000-0002-0524-2696 AD - Research and Development Center, Dayanand Medical College and Hospital, Ludhiana, 141 001, India. FAU - Malik, Sanya AU - Malik S AUID- ORCID: 0009-0007-6578-7480 AD - Department of Pharmacology, Dayanand Medical College and Hospital, Ludhiana, 141 001, India. FAU - Bhardwaj, Arshia AU - Bhardwaj A AUID- ORCID: 0000-0001-5820-7758 AD - Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, 141 001, India. FAU - Jena, Anuraag AU - Jena A AUID- ORCID: 0000-0001-9074-6698 AD - Department of Gastroenterology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, 751 029, India. FAU - Mahajan, Ramit AU - Mahajan R AUID- ORCID: 0000-0001-6726-6151 AD - Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, 141 001, India. FAU - Midha, Vandana AU - Midha V AUID- ORCID: 0000-0003-0192-3969 AD - Department of Internal Medicine, Dayanand Medical College and Hospital, Ludhiana, 141 001, India. FAU - Sood, Ajit AU - Sood A AUID- ORCID: 0000-0001-6961-6389 AD - Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, 141 001, India. ajitsood10@gmail.com. LA - eng PT - Journal Article PT - Meta-Analysis PT - Meta-Analysis PT - Systematic Review PT - Systematic Review DEP - 20260501 PL - India TA - Indian J Gastroenterol JT - Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology JID - 8409436 RN - 0 (Adrenal Cortex Hormones) SB - IM MH - Randomized Controlled Trials as Topic MH - Humans MH - *Enteral Nutrition/methods MH - *Crohn Disease/therapy MH - Adult MH - Remission Induction/methods MH - Treatment Outcome MH - Adrenal Cortex Hormones/therapeutic use MH - Male MH - Female OTO - NOTNLM OT - Adult OT - Crohn disease OT - Enteral nutrition OT - Glucocorticoids OT - Remission induction COIS- Declarations. Conflict of interest: Ajit Sood received honorarium for speaker events from Pfizer India and Takeda India. The remaining authors disclose no conflicts. Ethics approval: Not applicable. Permission to reproduce material from other sources: Not applicable. Disclaimer: The authors are solely responsible for the data and the contents of the paper. In no way, the Honorary Editor-in-Chief, Editorial Board Members, the Indian Society of Gastroenterology or the printer/publishers are responsible for the results/findings and contents of this article. EDAT- 2026/05/01 12:37 MHDA- 2026/05/11 13:00 CRDT- 2026/05/01 11:07 PHST- 2025/11/18 00:00 [received] PHST- 2026/02/18 00:00 [accepted] PHST- 2026/05/11 13:00 [medline] PHST- 2026/05/01 12:37 [pubmed] PHST- 2026/05/01 11:07 [entrez] AID - 10.1007/s12664-026-01989-3 [pii] AID - 10.1007/s12664-026-01989-3 [doi] PST - ppublish SO - Indian J Gastroenterol. 2026 Jun;45(3):452-473. doi: 10.1007/s12664-026-01989-3. Epub 2026 May 1. PMID- 42065159 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 18 DP - 2026 May 1 TI - Vitamin D concentrations and headache risk in children and adolescents aged 6 to 19 years: The mediating role of body mass index. PG - e48477 LID - 10.1097/MD.0000000000048477 [doi] LID - e48477 AB - Emerging evidence suggests vitamin D deficiency might be linked to increased headache risk, though consistent conclusions are lacking due to population and methodological heterogeneity. In addition, childhood and adolescent obesity may influence headache development through metabolic and inflammatory pathways, but the specific role of body mass index (BMI) in the relationship between vitamin D and headache is currently unclear. Therefore, this study used National Health and Nutrition Examination Survey (NHANES) large-scale population-based data to investigate the association between vitamin D levels and headache risk in children and adolescents aged 6 to 19 years and to analyze the possible mediating effect of BMI on this relationship. The aim of this study was to explore the complex association between vitamin D levels and headache. We analyzed 2 cycles of the NHANES dataset, which included a total of 7066 children and adolescents aged 6 to 19 years. Multivariate linear regression models, subgroup analyses and smoothed curve fitting were used to investigate the associations between vitamin D levels and headache, and the potential mediating role of BMI was explored. The results of the present study revealed a evident negative correlation between vitamin D levels and headache risk in children and adolescents, a finding that was further supported by smoothed curve fitting. Notably, this negative correlation was stronger in the female and adolescent groups. The results of the mediation analysis revealed that BMI had a evident mediating effect, with a mediation ratio of 20.94%. This study found that lower vitamin D levels were associated with a higher likelihood of headache in children and adolescents, and that BMI may play a partial mediating role. This finding provides new strategies for the prevention and treatment of headache in children and adolescents. More prospective studies are necessary to further validate this association and its underlying mechanisms. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Zhang, Min AU - Zhang M AUID- ORCID: 0009-0009-3102-755 AD - Department of Otolaryngology, Kunming Medical University Affiliated Children's Hospital (Kunming Children's Hospital), Kunming, Yunnan Province, China. FAU - Xie, Juan AU - Xie J AD - Yunnan Institute of Pediatrics, Yunnan Key Laboratory of Children's Major Disease Research, Yunnan Province Clinical Research Center for Children's Health and Disease, Kunming Medical University Affiliated Children's Hospital (Kunming Children's Hospital), Kunming, Yunnan Province, China. FAU - Guo, Cheng AU - Guo C AD - Comprehensive Pediatrics, Kunming Medical University Affiliated Children's Hospital (Kunming Children's Hospital), Kunming , Yunnan Province, China. FAU - Zhang, Tiesong AU - Zhang T AD - Department of Otolaryngology, Kunming Medical University Affiliated Children's Hospital (Kunming Children's Hospital), Kunming, Yunnan Province, China. FAU - Liu, Kai AU - Liu K AUID- ORCID: 0000-0002-3374-3375 AD - Comprehensive Pediatrics, Kunming Medical University Affiliated Children's Hospital (Kunming Children's Hospital), Kunming , Yunnan Province, China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - 1406-16-2 (Vitamin D) SB - IM MH - Humans MH - Adolescent MH - Child MH - Female MH - *Vitamin D/blood MH - *Body Mass Index MH - Male MH - *Headache/epidemiology/etiology/blood MH - *Vitamin D Deficiency/complications/epidemiology/blood MH - Nutrition Surveys MH - Young Adult MH - Risk Factors PMC - PMC13138427 OTO - NOTNLM OT - BMI OT - cross-sectional studies, headache, mediation analyses OT - vitamin D COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 12:36 PMCR- 2026/05/01 CRDT- 2026/05/01 05:33 PHST- 2025/09/04 00:00 [received] PHST- 2026/01/04 00:00 [accepted] PHST- 2026/05/01 12:36 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:33 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 00005792-202605010-00016 [pii] AID - MD-D-25-10671 [pii] AID - 10.1097/MD.0000000000048477 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 May 1;105(18):e48477. doi: 10.1097/MD.0000000000048477. PMID- 42065146 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260819 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 18 DP - 2026 May 1 TI - Impact of competitive anxiety on mood, sleep, and physical activity levels in young Tunisian karate athletes: A multidimensional prospective observational study. PG - e48435 LID - 10.1097/MD.0000000000048435 [doi] LID - e48435 AB - This study examined the impact of competition-related anxiety on psychological and behavioral parameters of Tunisian karate athletes. A total of 176 young Tunisian karate athletes (aged 16-25 years) with at least 1 year of training and competitive experience voluntarily participated in this study. Validated instruments were administered 1 week before and on the day of the competition, including the State-Trait Anxiety Inventory, the Pittsburgh Sleep Quality Index, the Brunel Mood Scale, and the International Physical Activity Questionnaire. Paired Wilcoxon signed-rank tests were used to compare changes over time, and multiple linear regression models were used to identify predictors of state and trait anxiety. Anxiety, mood, sleep, and physical activity changed from 1 week before to competition day (all P < .001). One week before, state anxiety was higher with tension (beta = 1.22, P < .001), fatigue (beta = 1.49, P < .001), and confusion (beta = 1.14, P < .001); trait anxiety was higher with anger (beta = 1.15, P < .001), depression (beta = 1.38, P < .001), and fatigue (beta = 0.42, P = .004), and lower with confusion (beta = -0.36, P = .009). State anxiety was positively associated with sleep disturbances (beta = 5.94, P < .001); trait anxiety with poorer subjective sleep quality (beta = 2.87, P < .001) and longer sleep latency (beta = 0.26, P < .001). Vigorous MET-minutes predicted lower state anxiety (beta = -0.009, P = .02) and walking predicted lower trait anxiety (beta = -0.007, P = .007). State anxiety increased with confusion (beta = 1.47, P < .001) and decreased with vigor (beta = -0.94, P = .003); trait anxiety increased with depression (beta = 1.53, P < .001) and fatigue (beta = 1.34, P < .001). Daytime dysfunction predicted higher state anxiety (beta = 8.91, P < .001) and sleep latency predicted higher trait anxiety (beta = 0.10, P = .031). Moderate MET-minutes predicted higher state anxiety (beta = 0.008, P = .02). Increases in state anxiety aligned with higher tension (beta = 0.93, P < .001), fatigue (beta = 0.61, P = .004), and confusion (beta = 1.89, P < .001), and decreases with depression (beta = -0.54, P = .02). Increases in trait anxiety were driven by depression (beta = 1.67, P < .001) and fatigue (beta = 1.06, P < .001). Greater daytime dysfunction predicted increases in state anxiety (beta = 9.28, P < .001), whereas longer sleep latency (beta = 0.19, P < .001) and shorter sleep duration (beta = -3.18, P < .001) predicted increases in trait anxiety; activity changes were not significant. Competition anxiety in young karate athletes is chiefly associated with mood disturbances and sleep parameters; implementing mood-regulation and sleep-focused strategies may reduce anxiety in youth combat sports. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Belgacem, Ahlem AU - Belgacem A AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. AD - Research Laboratory: Education, Motricite, Sport et Sante (EM2S, LR19JS01), High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. FAU - Salem, Atef AU - Salem A AUID- ORCID: 0000-0003-0680-6841 AD - Department of Training and Movement Science, Institute of Sport Science, Johannes Gutenberg-University Mainz, Mainz, Germany. FAU - Yildiz, Mevlut AU - Yildiz M AD - Coaching Sciences, Faculty of Sports Sciences, Mugla Sitki Kocman University, Mugla, Turkiye. FAU - Ceylan, Halil Ibrahim AU - Ceylan HI AD - Physical Education and Sports Teaching Department, Faculty of Sports Sciences, Ataturk University, Erzurum, Turkiye. FAU - Ben Hassen, Said AU - Ben Hassen S AD - Tunisian Research Laboratory Sports Performance Optimization, National Center of Medicine and Science in Sports (CNMSS), Tunis, Tunisia. FAU - Negra, Yassine AU - Negra Y AD - Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Tunis, Tunisia. FAU - Muntean, Raul Ioan AU - Muntean RI AUID- ORCID: 0000-0003-4615-6687 AD - Department of Physical Education and Sport, Faculty of Law and Social Sciences, University "1 Decembrie 1918" of Alba Iulia, Alba Iulia, Romania. FAU - Jarraya, Mohamed AU - Jarraya M AD - High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. AD - Research Laboratory: Education, Motricite, Sport et Sante (EM2S, LR19JS01), High Institute of Sport and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. LA - eng PT - Journal Article PT - Observational Study PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - *Anxiety/psychology/epidemiology MH - Male MH - Tunisia MH - *Martial Arts/psychology MH - *Affect/physiology MH - Adolescent MH - *Athletes/psychology MH - Prospective Studies MH - Young Adult MH - *Sleep/physiology MH - Female MH - Adult MH - Surveys and Questionnaires MH - *Exercise/psychology MH - Fatigue MH - Depression PMC - PMC13138430 OTO - NOTNLM OT - competitive anxiety OT - karate OT - mood disturbance OT - physical activity OT - regression analysis OT - sleep quality OT - youth athletes COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 12:36 PMCR- 2026/05/01 CRDT- 2026/05/01 05:33 PHST- 2025/10/06 00:00 [received] PHST- 2026/04/02 00:00 [accepted] PHST- 2026/05/01 12:36 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:33 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 00005792-202605010-00003 [pii] AID - MD-D-25-13333 [pii] AID - 10.1097/MD.0000000000048435 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 May 1;105(18):e48435. doi: 10.1097/MD.0000000000048435. PMID- 42065086 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260501 LR - 20260813 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Adapting a resistance training program for Danish physical education: teachers' preconceptions and participatory co-adaptation. PG - 1816683 LID - 10.3389/fspor.2026.1816683 [doi] LID - 1816683 AB - INTRODUCTION: Transferring and scaling school-based physical activity (PA) programs across educational contexts requires systematic adaptation to ensure implementation feasibility and contextual fit. This study examined Danish physical education (PE) teachers' preconceptions for resistance training and a participatory co-adaptation process used to adapt the evidence-based Resistance Training for Teens (RT4T) program for implementation in Danish lower secondary schools. METHODS AND MATERIALS: MEGAFiT, a Danish adaptation of RT4T, was developed using a sequential qualitative design. We conducted six online group interviews with 19 PE teachers and analysed data using the COM-B model to identify key implementation determinants related to capability, opportunity, and motivation. These findings informed four participatory co-adaptation workshops with 14 PE teachers, combining practical testing, reflection, and iterative program refinement. The resulting MEGAFiT program was structured as a six-week PE course consisting of modular, equipment-light resistance training sessions designed to integrate with PE content. Adaptations were documented using the Framework for Reporting Adaptations and Modifications-Expanded (FRAME). RESULTS: Teachers' capability and confidence to deliver resistance training varied substantially and were closely linked to prior experience. Key implementation barriers included limited lesson time, large class size, and restricted access to facilities and equipment. During the co-adaptation process, teachers and researchers collaboratively refined the program by shortening its duration, introducing modular lesson structures, developing equipment-light exercise formats, and redesigning instructional materials to improve usability in PE settings. CONCLUSION: Explicitly addressing implementer preconceptions through structured co-adaptation strengthened the alignment between the RT4T program and the Danish school context. The findings illustrate how participatory adaptation can help tailor evidence-based PA programs to everyday PE practice by aligning program structure, organization, and materials with teachers' capabilities and contextual constraints. CI - (c) 2026 Koch, Andersen, Larsen, Melcher, Bredahl, Meiner-Jensen, Lubans and Christiansen. FAU - Koch, Sofie AU - Koch S AD - Research Unit for Active Living, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. AD - Research and Implementation Centre for Human Movement and Learning, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Andersen, Marianne Friis AU - Andersen MF AD - Research Unit for Active Living, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. AD - Research and Implementation Centre for Human Movement and Learning, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Larsen, Malte Nejst AU - Larsen MN AD - Research and Implementation Centre for Human Movement and Learning, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. AD - Research Unit for Sport and Health Sciences, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Melcher, Jesper Ninn Sandfeld AU - Melcher JNS AD - Faculty of Teacher Education, University College Copenhagen, Copenhagen, Denmark. FAU - Bredahl, Thomas Viskum Gjelstrup AU - Bredahl TVG AD - Research Unit for Active Living, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. AD - Danish Centre for Motivation and Behaviour Science (DRIVEN), Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Meiner-Jensen, Christina Birch AU - Meiner-Jensen CB AD - Research Unit for Sport and Health Sciences, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Lubans, David R AU - Lubans DR AD - Global Sport and Movement Collaborative, University of Newcastle, Newcastle, NSW, Australia. AD - Hunter Medical Research Institute, New Lambton, NSW, Australia. FAU - Christiansen, Lars Breum AU - Christiansen LB AD - Research Unit for Active Living, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. AD - Research and Implementation Centre for Human Movement and Learning, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. LA - eng PT - Journal Article DEP - 20260415 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13124729 OTO - NOTNLM OT - adolescents OT - cultural adaptation OT - implementation OT - physical education OT - scaling COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 06:35 PMCR- 2026/04/15 CRDT- 2026/05/01 05:20 PHST- 2026/02/24 00:00 [received] PHST- 2026/03/16 00:00 [revised] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/05/01 06:35 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:20 [entrez] PHST- 2026/04/15 00:00 [pmc-release] AID - 10.3389/fspor.2026.1816683 [doi] PST - epublish SO - Front Sports Act Living. 2026 Apr 15;8:1816683. doi: 10.3389/fspor.2026.1816683. eCollection 2026. PMID- 42065000 OWN - NLM STAT- MEDLINE DCOM- 20260515 LR - 20260813 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 15 DP - 2026 TI - Anthropometry, energy, and nutrient intake of orphanage children (2-5 years) in eastern and western district of Kogi state. PG - e28 LID - 10.1017/jns.2026.10091 [doi] LID - e28 AB - Malnutrition in children remains a major global public health concern, especially in sub-Saharan Africa. A cross-sectional study was conducted among 120 children, with a sub-sample of 23 children selected for a 3-day weighed food intake assessment. Data were collected using a validated questionnaire, anthropometric measurements, and dietary intake records. Analysis was performed using SPSS version 21 and results were presented as means, frequencies, and percentages. The daily energy intake of children aged 4 and 5 years was below the recommended levels (74.1% and 64.3%, respectively). However, children aged 2 and 3 years had adequate energy intakes, exceeding the recommendations (102.4% and 111.5%). Iron intake across all age groups was below the recommended dietary intake. Intake of B-complex vitamins (B(1), B(2), B(3)) among 2-, 3-, and 5-year-olds exceeded recommended levels. Calcium intake was consistently low across all age groups (2 years: 37.5%, 3 years: 44.6%, 4 years: 23.5%, 5 years: 24.7%), this is due to low consumption of protein food sources and vegetables rich in calcium. Key factors influencing low nutritional status included inadequate consumption of high protein food sources, overreliance on carbohydrate food (cassava flour), poor consumption of fruits and vegetables, and inability to access food due to sickness. The study highlights suboptimal intake of energy and essential micronutrients among orphanage children, particularly older age groups. Nutrition education, improved feeding practices, and increased dietary diversity are essential to improve the nutritional status of children in orphanages. CI - (c) The Author(s) 2026. FAU - Nweze, Ifedilichukwu Emilia AU - Nweze IE AUID- ORCID: 0009-0005-8121-2092 AD - Natural Science Unit, School of General Studies, University of Nigeria, Nsukka, Enugu 410101, Nigeria. ROR: https://ror.org/01sn1yx84 FAU - Ibeanu, Vivienne N AU - Ibeanu VN AD - Department of Nutrition and Dietetics, Faculty of Agriculture, University of Nigeria, Nsukka, Enugu 410101, Nigeria. FAU - Onyia, Uchechukwu AU - Onyia U AD - Department of Home Science and Management, Faculty of Agriculture, University of Nigeria, Nsukka, Enugu, 410101, Nigeria. FAU - Tochukwu Onyemaechi, Ijeoma AU - Tochukwu Onyemaechi I AD - Department of Human Nutrition and Dietetics, Enugu State University of Science and Technology, Enugu, Nigeria. LA - eng PT - Journal Article DEP - 20260427 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 RN - 0 (Dietary Carbohydrates) RN - 0 (Dietary Proteins) RN - 0 (Vitamins) RN - 0 (Trace Elements) SB - IM MH - Humans MH - Child Nutrition Disorders/etiology/prevention & control MH - Child, Preschool MH - Nigeria MH - *Orphanages MH - Anthropometry MH - *Energy Intake MH - *Eating MH - Male MH - Female MH - Socioeconomic Factors MH - Diet MH - Dietary Carbohydrates/administration & dosage MH - Dietary Proteins/administration & dosage MH - Vegetables MH - Vitamins/administration & dosage MH - Trace Elements/administration & dosage MH - Schools PMC - PMC13126059 OTO - NOTNLM OT - Anthropometry OT - Diversity OT - Energy intake OT - Intake OT - Malnutrition OT - Nutrient OT - Nutrient intake OT - Orphanage children OT - Weight OT - food COIS- The authors declare none. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 06:35 PMCR- 2026/04/27 CRDT- 2026/05/01 05:20 PHST- 2025/06/19 00:00 [received] PHST- 2025/11/28 00:00 [revised] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/05/01 06:35 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:20 [entrez] PHST- 2026/04/27 00:00 [pmc-release] AID - S2048679026100913 [pii] AID - 10.1017/jns.2026.10091 [doi] PST - epublish SO - J Nutr Sci. 2026 Apr 27;15:e28. doi: 10.1017/jns.2026.10091. eCollection 2026. PMID- 42064999 OWN - NLM STAT- MEDLINE DCOM- 20260521 LR - 20260813 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 15 DP - 2026 TI - Association of gut microbiota dietary index with MAFLD and the risk of liver fibrosis: the mediating effect of vitamins. PG - e23 LID - 10.1017/jns.2026.10093 [doi] LID - e23 AB - Metabolic dysfunction-associated fatty liver disease (MAFLD) is emerging as the leading cause of chronic liver disease worldwide, with a spectrum ranging from simple steatosis to advanced fibrosis and cirrhosis. Its pathogenesis is multifactorial and involves genetic, metabolic, and gut microbiota factors. Gut microbiota, through the gut-liver axis, plays a crucial role in the progression of MAFLD. Here, we investigated the association between DI-GM, a novel metric reflecting diet-microbiota interactions, MAFLD, and liver fibrosis, with a focus on the mediating role of vitamins. Using data from 13,498 participants across seven NHANES cycles (2007-2018), we found that higher DI-GM scores, indicative of a healthier gut microbiota-promoting diet, were associated with a reduced prevalence of MAFLD (OR = 0.93, 95% CI = 0.88-0.99) and high-risk liver fibrosis (OR = 0.94, 95% CI = 0.90-0.98) in fully adjusted models. Notably, the relationship between DI-GM and MAFLD and the risk of liver fibrosis is largely mediated by specific vitamins and carotenoids, with vitamin C and cis-beta-carotene emerging as key mediators. These findings suggest that dietary interventions targeting the gut microbiota and vitamin supplementation could offer new strategies for the prevention and management of MAFLD. Our study provides the first comprehensive evidence linking DI-GM to MAFLD and the risk of liver fibrosis, highlighting the potential of diet and nutrition to modulate metabolic liver diseases. Future research should focus on elucidating the underlying mechanisms and validating these findings through prospective studies and clinical trials. CI - (c) The Author(s) 2026. FAU - Han, Jinlu AU - Han J AD - Tongren Hospital Shanghai Jiaotong University School of Medicine, China. ROR: https://ror.org/01r8rcr36 FAU - Zhou, Teng AU - Zhou T AD - Fudan University Shanghai Cancer Center, China. FAU - Chen, Jiong AU - Chen J AD - Tongren Hospital Shanghai Jiaotong University School of Medicine, China. ROR: https://ror.org/01r8rcr36 FAU - Xu, Ling AU - Xu L AD - Tongren Hospital Shanghai Jiaotong University School of Medicine, China. ROR: https://ror.org/01r8rcr36 FAU - Shan, Wen AU - Shan W AD - No 2 People's Hospital of Fuyang City, China. FAU - Zhang, Qinghui AU - Zhang Q AUID- ORCID: 0000-0003-2164-6452 AD - Tongren Hospital Shanghai Jiaotong University School of Medicine, China. ROR: https://ror.org/01r8rcr36 LA - eng PT - Journal Article DEP - 20260413 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 RN - 0 (Vitamins) SB - IM MH - *Gastrointestinal Microbiome MH - *Non-alcoholic Fatty Liver Disease/complications/epidemiology/microbiology MH - Nutrition Assessment MH - *Liver Cirrhosis/epidemiology/etiology/microbiology/prevention & control MH - Risk Factors MH - *Diet/adverse effects/statistics & numerical data MH - Mediation Analysis MH - Nutrition Surveys MH - Prevalence MH - Vitamins/administration & dosage MH - Dietary Supplements MH - Cross-Sectional Studies MH - Humans MH - Male MH - Female MH - Infant, Newborn MH - Infant MH - Child, Preschool MH - Child MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged MH - Aged MH - United States/epidemiology PMC - PMC13126062 OTO - NOTNLM OT - Dietary Index of Gut Microbiota OT - dietary nutrition OT - liver fibrosis OT - metabolic-associated fatty liver disease OT - vitamin mediation COIS- The authors declare no competing interests. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 13:48 PMCR- 2026/04/13 CRDT- 2026/05/01 05:20 PHST- 2025/04/22 00:00 [received] PHST- 2026/01/19 00:00 [revised] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/05/01 13:48 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:20 [entrez] PHST- 2026/04/13 00:00 [pmc-release] AID - S2048679026100937 [pii] AID - 10.1017/jns.2026.10093 [doi] PST - epublish SO - J Nutr Sci. 2026 Apr 13;15:e23. doi: 10.1017/jns.2026.10093. eCollection 2026. PMID- 42064996 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 15 DP - 2026 TI - High risk of disordered eating is associated with body composition, behavioural factors, and perceived stress among university students: a cross-sectional study from the UAE. PG - e25 LID - 10.1017/jns.2026.10089 [doi] LID - e25 AB - Disordered eating (DE) significantly affects both physical and mental health, contributing to morbidity, mortality, and considerable global healthcare costs. This cross-sectional study assessed the prevalence of high-risk DE and examined its associations with body composition, behavioural factors, diet quality, and perceived stress among university students in the United Arab Emirates. A total of 911 students were recruited using non-probability quota sampling (50.49% female). Body composition was measured using a TANITA BC-420MA body composition monitor. Usual dietary intake was assessed via a validated 65-item food frequency questionnaire. DE risk was assessed using the Eating Attitudes Test (EAT-26) and perceived stress using the PSS-10. Analysis included linear regression and independent-samples t-test (p < 0.05). High-risk DE (EAT-26 >/= 20) prevalence was 30.3%. High-risk DE was significantly associated with higher body fat percentage (beta = 0.121, p < 0.001), fat mass (beta = 0.148, p < 0.001), fat-free mass (beta = 0.079, p = 0.017), lean mass (beta = 0.08, p = 0.016), total body water (beta = 0.084, p = 0.011), and lower total body water percentage (beta = -0.131, p < 0.001). High-risk students also reported higher intakes of fibre (beta = 0.12, p = 0.018), beta-carotene (beta = 0.14, p = 0.025), vitamin A (beta = 0.13, p = 0.034), B12 (beta = 0.15, p = 0.043), folate (beta = 0.16, p = 0.006), and vitamin D (beta = 0.16, p = 0.036). Compared with the low-risk group, high-risk DE was associated with higher adiposity markers and slightly higher perceived stress, and differed in selected nutrient intakes; sociodemographic characteristics were largely similar between groups except for smoking status. These findings support the implementation of targeted prevention strategies, including nutrition education, routine screening, and culturally tailored programmes, for young adults in the UAE. CI - (c) The Author(s) 2026. FAU - Cheikh Ismail, Leila AU - Cheikh Ismail L AD - Department of Clinical Nutrition and Dietetics, University of Sharjah, United Arab Emirates. ROR: https://ror.org/00engpz63 AD - Nuffield Department of Women's & Reproductive Health, University of Oxford, UK. ROR: https://ror.org/052gg0110 FAU - Faris, MoezAlIslam AU - Faris M AD - Department of Clinical Nutrition and Dietetics, Applied Science Private University, Jordan. FAU - Abdelrahim, Dana N AU - Abdelrahim DN AUID- ORCID: 0000-0002-5111-7132 AD - Research Institute for Medical and Health Sciences, University of Sharjah, United Arab Emirates. FAU - Zeb, Falak AU - Zeb F AD - Research Institute for Medical and Health Sciences, University of Sharjah, United Arab Emirates. FAU - Mohamad, Maysm N AU - Mohamad MN AUID- ORCID: 0000-0002-6396-6625 AD - Department of Nutrition and Health, United Arab Emirates University, United Arab Emirates. ROR: https://ror.org/01km6p862 FAU - Amer, Enas AU - Amer E AD - Department of Clinical Nutrition and Dietetics, University of Sharjah, United Arab Emirates. ROR: https://ror.org/00engpz63 FAU - Alali, Maram AU - Alali M AD - Department of Clinical Nutrition and Dietetics, University of Sharjah, United Arab Emirates. ROR: https://ror.org/00engpz63 FAU - Draghmeh, Marianna AU - Draghmeh M AD - Department of Clinical Nutrition and Dietetics, University of Sharjah, United Arab Emirates. ROR: https://ror.org/00engpz63 FAU - Ben-Mustafa, Najat AU - Ben-Mustafa N AD - Department of Clinical Nutrition and Dietetics, University of Sharjah, United Arab Emirates. ROR: https://ror.org/00engpz63 FAU - Stojanovska, Lily AU - Stojanovska L AD - Institute for Health and Sport, Victoria University, Australia. FAU - Al Dhaheri, Ayesha Salem AU - Al Dhaheri AS AUID- ORCID: 0000-0002-7634-3531 AD - Department of Nutrition and Health, United Arab Emirates University, United Arab Emirates. ROR: https://ror.org/01km6p862 LA - eng PT - Journal Article DEP - 20260415 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - *Body Composition MH - United Arab Emirates/epidemiology MH - Male MH - *Students MH - Universities MH - Young Adult MH - *Feeding and Eating Disorders/epidemiology/psychology MH - Subjective Stress MH - Diet MH - *Feeding Behavior MH - Adult MH - Risk Factors MH - Adolescent MH - *Stress, Psychological MH - Prevalence MH - Surveys and Questionnaires PMC - PMC13126061 OTO - NOTNLM OT - Anthropometry OT - Body composition OT - Diet quality OT - Disordered eating OT - Eating attitudes OT - Perceived stress OT - University students COIS- The author(s) declare none. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 06:35 PMCR- 2026/04/15 CRDT- 2026/05/01 05:20 PHST- 2025/12/25 00:00 [received] PHST- 2026/01/26 00:00 [revised] PHST- 2026/02/13 00:00 [accepted] PHST- 2026/05/01 06:35 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:20 [entrez] PHST- 2026/04/15 00:00 [pmc-release] AID - S2048679026100895 [pii] AID - 10.1017/jns.2026.10089 [doi] PST - epublish SO - J Nutr Sci. 2026 Apr 15;15:e25. doi: 10.1017/jns.2026.10089. eCollection 2026. PMID- 42064895 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Maternal health literacy as a potential determinant of infant and early childhood health: a systematic review. PG - 1743880 LID - 10.3389/fpubh.2026.1743880 [doi] LID - 1743880 AB - BACKGROUND: Maternal health literacy (MHL) represents a potentially modifiable public health determinant concentrated among socioeconomically disadvantaged populations. While 15-45% of pregnant women demonstrate inadequate health literacy, its impact across the full spectrum of infant and early childhood outcomes remains inadequately characterized, limiting understanding of its broader public health significance. OBJECTIVE: To systematically synthesize evidence on associations between MHL and infant/child health outcomes from birth through age three, and to examine whether MHL functions as a systemic determinant across outcome domains. METHODS: Following PRISMA guidelines, we searched MEDLINE, Embase, and Web of Science from inception through March 2025. Studies examining associations between validated MHL measures and any child health outcomes up to age three were included. Methodological quality was assessed using JBI checklists, and the certainty of evidence using the GRADE framework. Narrative synthesis was conducted. RESULTS: Eight studies (n = 13,407 participants) from seven countries met inclusion criteria. Higher MHL was consistently associated with favorable birth weight. A pattern consistent with a behavioral pathway hypothesis emerged: outcomes requiring maternal behavioral competencies (e.g., symptom recognition, care-seeking) showed stronger and more consistent associations (e.g., reduced neonatal jaundice readmission, diaper dermatitis) than medically-determined conditions. Limited evidence also suggested MHL effects beyond the perinatal period, with inadequate MHL associated with increased risks of nutritional deficiencies and developmental delays (over four-fold increased risk in vulnerable populations). JBI assessment indicated generally adequate quality, while GRADE rated the certainty of evidence as Low to Very Low due to cross-sectional designs and imprecision. CONCLUSION: MHL shows promising systematic associations with infant outcomes across multiple domains spanning the early life course, operating primarily through behavioral pathways requiring maternal agency. This pattern supports conceptualizing MHL as a potential foundational public health determinant and equity-relevant intervention target. However, low certainty of evidence underscores the need for standardized measurement, longitudinal studies, and intervention trials to establish causality. CI - Copyright (c) 2026 Li, Li, Yao and Ma. FAU - Li, Zanmei AU - Li Z AD - Institute of Medical Information and Library, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Li, Jiao AU - Li J AD - Institute of Medical Information and Library, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. FAU - Yao, Weiwei AU - Yao W AD - Beijing MYYA Health Management Co., Ltd., Beijing, China. FAU - Ma, Liangkun AU - Ma L AD - Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Beijing, China. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260415 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Health Literacy/statistics & numerical data MH - Female MH - Infant MH - *Child Health/statistics & numerical data MH - Infant, Newborn MH - *Infant Health MH - Child, Preschool MH - Pregnancy MH - *Mothers PMC - PMC13125130 OTO - NOTNLM OT - behavioral pathways OT - early childhood health OT - health equity OT - maternal health literacy OT - public health determinants OT - systematic review COIS- WY was employed by Beijing MYYA Health Management Co., Ltd. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 06:35 PMCR- 2026/04/15 CRDT- 2026/05/01 05:19 PHST- 2025/11/11 00:00 [received] PHST- 2026/03/19 00:00 [revised] PHST- 2026/04/03 00:00 [accepted] PHST- 2026/05/01 06:35 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:19 [entrez] PHST- 2026/04/15 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1743880 [doi] PST - epublish SO - Front Public Health. 2026 Apr 15;14:1743880. doi: 10.3389/fpubh.2026.1743880. eCollection 2026. PMID- 42064474 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260501 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 3 DP - 2026 Mar TI - Teacher Perspectives on Standing Desks in the Classroom: A Community-Engaged Approach to Reducing Sedentary Behavior in Youth. PG - e106145 LID - 10.7759/cureus.106145 [doi] LID - e106145 AB - Objective Reducing sedentary behavior in youth is a global health priority, with classroom-based interventions, such as standing desks, offering potential benefits. This study used community-engaged research (CEnR) methods to inform the development of a standing desk intervention by assessing teacher perspectives on implementation barriers and relevant study outcomes in K-12 schools. Methods An electronic survey was administered on February 7-8, 2024, to Pennsylvania teachers via the Penn State PRO Wellness Healthy Champions program, which provides online wellness resources to schools, along with the publication of a monthly newsletter. Eligible respondents taught K-12 students in brick-and-mortar schools. The 48-item survey assessed demographics, use of activity-permissive learning environments (APLE) including standing desks, willingness to trial APLE, and acceptability of study outcomes. Results Of 81 initial respondents, 48 met the inclusion criteria. Teachers were predominantly white (44/48, 91.7%), female (34/48, 70.8%), and > 40 years old (26/48, 54.2%). Most (45/48, 93.8%) used traditional desks; only (14/48, 29.2%) currently use APLE. A majority (30/48, 62.5%) expressed willingness to trial standing desks. Barriers included cost, space limitations, and lack of administrative support. Teachers prioritized improvements in student concentration (22/48, 45.8%) over health-related outcomes. Questionnaire-based outcome measures were most acceptable, while biometric measures (e.g., BMI, blood pressure) and finger-prick blood collection were viewed less favorably. Logistic regression found no demographic predictors of willingness to trial standing desks. Conclusion Teachers' interest in classroom standing desks centers on potential benefits for student focus and behavior, with hesitancy around health data collection and logistical constraints. These findings guided the research team's CEnR approach to school partnerships, resulting in the inclusion of concentration-related outcomes and planning for barriers in the study design. Engaging educators early in the research process supported alignment between research goals and community priorities, enhancing the feasibility of a school-based standing desk intervention. CI - Copyright (c) 2026, Wasserstein et al. FAU - Wasserstein, Katie L AU - Wasserstein KL AD - Department of Pediatrics, Penn State College of Medicine, Hershey, USA. FAU - Byerly, Caitlin M AU - Byerly CM AD - Department of Pediatrics, Penn State College of Medicine, Hershey, USA. FAU - Schaefer, Eric W AU - Schaefer EW AD - Department of Public Health Sciences, Penn State College of Medicine, Hershey, USA. FAU - Benden, Mark E AU - Benden ME AD - Department of Environmental and Occupational Health, Texas A&M University School of Public Health, College Station, USA. FAU - Sekhar, Deepa L AU - Sekhar DL AD - Department of Pediatrics, Penn State College of Medicine, Hershey, USA. LA - eng PT - Journal Article DEP - 20260330 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13128034 OTO - NOTNLM OT - activity permissive learning environment OT - community-engaged research OT - school-based interventions OT - standing desk OT - teacher opinion COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Penn State Institutional Review Board issued approval STUDY00023940. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: The participant stipends in this research were supported by the Children's Miracle Network. The use of REDCap (Research Electronic Data Capture) in this project was supported by the National Center for Advancing Translational Sciences, National Institutes of Health (NIH) (Grant UL1 TR002014). Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 06:35 PMCR- 2026/03/30 CRDT- 2026/05/01 05:15 PHST- 2026/03/29 00:00 [accepted] PHST- 2026/05/01 06:35 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:15 [entrez] PHST- 2026/03/30 00:00 [pmc-release] AID - 10.7759/cureus.106145 [doi] PST - epublish SO - Cureus. 2026 Mar 30;18(3):e106145. doi: 10.7759/cureus.106145. eCollection 2026 Mar. PMID- 42064155 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260501 LR - 20260813 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Gut microbiota profiles in anorexia nervosa: associations with disease severity, BMI, and history of childhood trauma. PG - 1759115 LID - 10.3389/fpsyt.2026.1759115 [doi] LID - 1759115 AB - STUDY OBJECTIVES: Emerging evidence suggests a possible link between anorexia nervosa (AN) and alterations in the gut microbiota. This study aimed to characterize the gut microbiota profile in a cohort of Chinese female patients with AN. METHOD: A comparative analysis of the gut microbiota was conducted between 30 female patients with AN and 30 sex- and age-matched healthy controls (HCs). Fecal samples were collected for 16S rRNA gene sequencing analysis. All participants were assessed using the Eating Disorder Inventory (EDI) and the Childhood Trauma Questionnaire (CTQ). Bioinformatics analysis was performed using QIIME2, and statistical analyses were carried out with SPSS 26.0 and R software. Correlations between microbiota differences and body mass index (BMI), EDI, and CTQ were further investigated. RESULTS: The analysis revealed differences in beta diversity and the abundances of specific microbial taxa between the two groups; however, no significant differences were observed in alpha diversity nor in the associations between gut microbiota and BMI, disease severity, or childhood trauma. CONCLUSIONS: This study identified limited differences in the gut microbiota composition between patients with AN and HCs. Critically, no robust associations between gut microbiota and clinical features were found after rigorous multiple comparison correction. While nominal (uncorrected) correlations were observed between the specific microbiota and psychological traits, these results are exploratory and should be considered hypothesis-generating. They highlight a potential avenue for future research but require validation in larger, longitudinal cohorts to determine their reproducibility and biological significance. CI - Copyright (c) 2026 Wang, Wang, Ma, Liu, Li and Zhang. FAU - Wang, Meiou AU - Wang M AD - Mental Health Center, National Center for Mental Disorders, West China Hospital, Sichuan University, Chengdu, China. FAU - Wang, Yu AU - Wang Y AD - Mental Health Center, National Center for Mental Disorders, West China Hospital, Sichuan University, Chengdu, China. FAU - Ma, Jing AU - Ma J AD - Mental Health Center, National Center for Mental Disorders, West China Hospital, Sichuan University, Chengdu, China. FAU - Liu, Yang AU - Liu Y AD - Mental Health Center, National Center for Mental Disorders, West China Hospital, Sichuan University, Chengdu, China. FAU - Li, Jin AU - Li J AD - Mental Health Center, National Center for Mental Disorders, West China Hospital, Sichuan University, Chengdu, China. FAU - Zhang, Lan AU - Zhang L AD - Mental Health Center, National Center for Mental Disorders, West China Hospital, Sichuan University, Chengdu, China. LA - eng PT - Journal Article DEP - 20260415 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13125984 OTO - NOTNLM OT - anorexia nervosa OT - childhood trauma OT - diversity OT - eating disorder OT - gut microbiota COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 06:35 PMCR- 2026/04/15 CRDT- 2026/05/01 05:11 PHST- 2025/12/02 00:00 [received] PHST- 2026/03/19 00:00 [revised] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/05/01 06:35 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:11 [entrez] PHST- 2026/04/15 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1759115 [doi] PST - epublish SO - Front Psychiatry. 2026 Apr 15;17:1759115. doi: 10.3389/fpsyt.2026.1759115. eCollection 2026. PMID- 42064151 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260501 LR - 20260813 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Faecal inflammatory protein markers in children with autism spectrum disorder are comparable to their healthy siblings. PG - 1792801 LID - 10.3389/fpsyt.2026.1792801 [doi] LID - 1792801 AB - BACKGROUND: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition often accompanied by gastrointestinal (GI) symptoms. Inflammatory proteins in stool have been proposed as potential biomarkers, but evidence remains inconsistent. We compared fecal levels of alpha1-antitrypsin (A1AT), immunoglobulin A (IgA), and calprotectin (Cal) in 57 children with ASD and 57 biological siblings without ASD. Sibling designs are now preferred to disentangle ASD-specific biology from shared environmental and microbiome factors. Participants were carefully screened to exclude recent antibiotic use, digestive problems, gastrointestinal infections, and abnormal dietary patterns, thereby controlling for major factors known to influence gut inflammatory markers. METHODS: Stool samples were thawed, freeze-dried, and proteins extracted using ammonium bicarbonate buffer with sodium deoxycholate. After BCA quantification, samples were reduced, alkylated, spiked with stable isotope-labelled peptides, and digested with trypsin. Peptides were purified and analyzed by UHPLC-MS/MS (Agilent 6495A) in dynamic SRM mode. Quantification used internal standards and normalization to total protein. Ratios of IgA1/IgA2 and S100A8/S100A9 were calculated. ASD severity was evaluated using the Childhood Autism Rating Scale (CARS). RESULTS: Children with ASD showed trends toward higher IgA and calprotectin and lower alpha1-antitrypsin compared with siblings, but differences were not statistically significant. Subgroup analysis suggested different distribution patterns in moderate versus severe ASD, including higher IgA in the moderate group and altered S100A8/S100A9 ratio in the severe group. These subgroup findings were exploratory, derived from critically underpowered post-hoc analyses (severe subgroup: n = 11 pairs, ~18% power for medium effects), and should be considered hypothesis-generating only, pending validation in adequately powered pre-registered studies. CONCLUSIONS: The results are consistent with recent meta-analyses reporting no consistent evidence of gut inflammation in ASD. Larger, sex-matched studies with full assay validation are needed to clarify the role of stool proteins in ASD. CI - Copyright (c) 2026 Osredkar, Finderle, Godnov, Jekovec-Vrhovsek, Vidova, Elliott, Fabjan, Avgustin, Osredkar and Kumer. FAU - Osredkar, Josko AU - Osredkar J AD - Institute of Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Ljubljana, Slovenia. AD - Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia. FAU - Finderle, Petra AU - Finderle P AD - Institute of Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Ljubljana, Slovenia. FAU - Godnov, Uros AU - Godnov U AD - The Faculty of Mathematics, Natural Sciences and Information Technologies, University of Ljubljana, Koper, Slovenia. FAU - Jekovec-Vrhovsek, Maja AU - Jekovec-Vrhovsek M AD - Center for Autism, Unit of Child Psychiatry, University Children's Hospital, University Medical Centre Ljubljana, Ljubljana, Slovenia. FAU - Vidova, Veronika AU - Vidova V AD - Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Brno, Czechia. AD - Environmental Exposure Assessment Research Infrastructure-Czech Republic (EIRENE-CZ), Brno, Czechia. FAU - Elliott, James Price AU - Elliott JP AD - Research Centre for Toxic Compounds in the Environment (RECETOX), Faculty of Science, Masaryk University, Brno, Czechia. AD - Environmental Exposure Assessment Research Infrastructure-Czech Republic (EIRENE-CZ), Brno, Czechia. FAU - Fabjan, Teja AU - Fabjan T AD - Institute of Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Ljubljana, Slovenia. FAU - Avgustin, Gorazd AU - Avgustin G AD - Department of Microbiology, Biotechnical Faculty, University of Ljubljana, Domzale, Slovenia. FAU - Osredkar, Damjan AU - Osredkar D AD - Division of Pediatrics, Department of Child, Adolescent and Developmental Neurology, University Medical Centre Ljubljana, Ljubljana, Slovenia. AD - Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia. FAU - Kumer, Kristina AU - Kumer K AD - Institute of Clinical Chemistry and Biochemistry, University Medical Centre Ljubljana, Ljubljana, Slovenia. LA - eng PT - Journal Article DEP - 20260415 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13125985 OTO - NOTNLM OT - alpha-1-antitrypsin OT - autism spectrum disorder OT - calprotectin OT - immunoglobulin A OT - siblings OT - stool samples COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author JO declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 06:35 PMCR- 2026/04/15 CRDT- 2026/05/01 05:11 PHST- 2026/01/21 00:00 [received] PHST- 2026/03/03 00:00 [revised] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/05/01 06:35 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:11 [entrez] PHST- 2026/04/15 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1792801 [doi] PST - epublish SO - Front Psychiatry. 2026 Apr 15;17:1792801. doi: 10.3389/fpsyt.2026.1792801. eCollection 2026. PMID- 42063741 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260813 IS - 2731-085X (Electronic) IS - 2731-085X (Linking) VI - 5 IP - 1 DP - 2026 TI - Investigating food-related behaviors in Smith-Magenis syndrome: tailoring a questionnaire for a rare disease. PG - 49 LID - 10.1007/s44162-026-00193-3 [doi] LID - 49 AB - PURPOSE: Accurate measurement is essential for tracking changes in clinical outcomes. Individuals with Smith-Magenis syndrome (SMS) exhibit challenging and unique food-related behaviors. We sought to determine the best tool to capture their unique food-related behaviors. METHODS: We conducted focus groups with caregivers of individuals with SMS to evaluate two commonly used questionnaires for food-related behaviors- the Food Related Problems Questionnaire (FRPQ) and the Hyperphagia Questionnaire for Clinical Trials (HQ-CT). Based on caregiver input and clinical expertise, we adapted these existing measures into a new tool: the SMS-FRPQ. We then validated this instrument for internal consistency and concurrent validity using online responses from 125 caregivers. RESULTS: Caregivers (n = 24) indicated neither the FRPQ or HQ-CT fully captured their child's food-related behaviors; however, the newly developed SMS-FRPQ was deemed comprehensive by a new group of caregivers (n = 19). The SMS-FRPQ demonstrated strong internal consistency, with a Cronbach's alpha of alpha = 0.87 [0.84-0.90]. Factor analysis indicated a three-factor model was a good fit (comparative fit index (CFI) = 0.9, Tucker-Lewis index (TLI) = 0.88). The three factors each showed good internal consistency: Desire for Food, alpha = 0.80 [0.74-0.85]; Takes Food, alpha = 0.87 [0.83-0.90]; Satiety Impairment, alpha = 0.83 [0.77-0.87]. The SMS-FRPQ showed higher internal reliability than the FRPQ. Concurrent validity was supported through alignment with similar items from the HQ-CT or Behavioral Problems Inventory (BPI-01). CONCLUSIONS: The SMS-FRPQ has 14 items across 3 different factors and 5 additional clinically relevant items. This validated tool may be useful for tracking food-related behavior outcomes in clinical trials for this high-risk population. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s44162-026-00193-3. CI - (c) The Author(s) 2026. FAU - Elatrash, Citrine AU - Elatrash C AD - Department of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, 1100 Bates St., Houston, TX 77030 USA. ROR: https://ror.org/02pttbw34. GRID: grid.39382.33. ISNI: 0000 0001 2160 926X FAU - Wilson, Theresa A AU - Wilson TA AD - Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030 USA. ROR: https://ror.org/02pttbw34. GRID: grid.39382.33. ISNI: 0000 0001 2160 926X FAU - Wood, Alexis C AU - Wood AC AD - Department of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, 1100 Bates St., Houston, TX 77030 USA. ROR: https://ror.org/02pttbw34. GRID: grid.39382.33. ISNI: 0000 0001 2160 926X FAU - Elsea, Sarah H AU - Elsea SH AD - Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030 USA. ROR: https://ror.org/02pttbw34. GRID: grid.39382.33. ISNI: 0000 0001 2160 926X AD - BCM-Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030 USA. ROR: https://ror.org/02pttbw34. GRID: grid.39382.33. ISNI: 0000 0001 2160 926X FAU - Sisley, Stephanie AU - Sisley S AD - Department of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, 1100 Bates St., Houston, TX 77030 USA. ROR: https://ror.org/02pttbw34. GRID: grid.39382.33. ISNI: 0000 0001 2160 926X LA - eng PT - Journal Article DEP - 20260429 PL - Germany TA - J Rare Dis (Berlin) JT - Journal of rare diseases (Berlin, Germany) JID - 9918522486706676 PMC - PMC13124879 OTO - NOTNLM OT - Food-related behaviors OT - Hyperphagia OT - Obesity OT - Questionnaire development OT - Smith-Magenis syndrome COIS- Competing interestsFinancial interests: Both SHE and SS have received research and consulting funds from Rhythm Pharmaceuticals. SS has received research funds from NIH and Eli Lilly and Company. SHE has research funding from the NIH, PTC Therapeutics, Speragen, Inc, and PRISMS, Inc. PRISMS, Inc. supports the SMS Patient Registry, which is housed at Baylor College of Medicine. All other authors declare no financial conflicts of interest. Non-financial interests: none. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 06:35 PMCR- 2026/04/29 CRDT- 2026/05/01 05:07 PHST- 2025/08/21 00:00 [received] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/05/01 06:35 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 05:07 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - 193 [pii] AID - 10.1007/s44162-026-00193-3 [doi] PST - ppublish SO - J Rare Dis (Berlin). 2026;5(1):49. doi: 10.1007/s44162-026-00193-3. Epub 2026 Apr 29. PMID- 42063181 OWN - NLM STAT- MEDLINE DCOM- 20260618 LR - 20260813 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 27 IP - 1 DP - 2026 May 1 TI - AdoHealth e-wellness initiative for adolescent non-communicable disease risk reduction: protocol for a school-based cluster randomised controlled trial in SAS Nagar (Mohali), Punjab, India. LID - 10.1186/s13063-026-09724-1 [doi] LID - 448 AB - BACKGROUND: Non-communicable diseases (NCDs) increasingly affect adolescents, particularly in low- and middle-income countries. Seven key lifestyle behaviours, alcohol and tobacco use, consumption of JUNCS foods (junk, ultra-processed, nutritionally inappropriate, caffeinated/coloured/carbonated foods/beverages, sugar-sweetened beverages); physical inactivity; inadequate sleep; excessive screen time; and stress, collectively termed the 'Big-7 Behavioural Risk Determinants', contribute to NCD onset in adolescence and persistence into adulthood. OBJECTIVE: To determine the effectiveness of the AdoHealth e-wellness initiative in reducing the Big-7 Behavioural Risk Determinants among school-going adolescents aged 14-17 years, measured as change from baseline at 6 and 12 months post-intervention compared with control schools. METHODS: This multisite, open-label, superiority cluster randomised controlled trial will include 180 high and senior secondary schools (Classes 9-12, ages 14-17 years; including public and private) in SAS Nagar (Mohali), Punjab, India, randomly assigned in a 1:1 ratio to intervention or control groups, stratified by school location (urban/rural) and school type (government/private). Participants will be recruited by trained field investigators. Eligible participants are students aged 14-17 years enrolled in participating schools, with written parental consent and adolescent assent; students with serious health conditions or planned school transfer will be excluded. The intervention comprises e-modules (10-15 min each) on the Big-7 Behavioural Risk Determinants, delivered via classroom smartboards with facilitator support, over 8 weekly sessions. A pilot phase will be conducted in one school (approximately 100 adolescents) prior to full-scale implementation. Behavioural and biochemical assessments using standardised tools will be conducted at baseline, 6 months, and 12 months post-intervention. Safety monitoring includes adverse event reporting and referral for psychological support as needed. The planned sample size is 18,000 students (9000 per arm across 90 clusters each). The primary endpoint is the change in the 'Big-7 Behavioural Risk Determinants' at 12 months post-intervention, while secondary endpoints include intermediate behavioural changes, biochemical risk markers, and overall well-being. EXPECTED IMPACT: This study aims to evaluate the feasibility and potential effectiveness of school-based e-wellness interventions targeting multiple health behaviours simultaneously. If successful, findings may contribute to early NCD prevention strategies and inform policy development for adolescent health promotion programs in low- and middle-income countries. TRIAL REGISTRATION STATEMENT: Trial registration: Clinical Trials Registry of India (CTRI), CTRI/2025/01/079797. Registered on January 30, 2025. https://ctri.nic.in/Clinicaltrials/rmaindet.php?trialid=121397&EncHid=98502.11769&modid=1&compid=19 . First participant recruitment commenced on August 16, 2025. CI - (c) 2026. The Author(s). FAU - Virk, Amrit AU - Virk A AD - Department of Community Medicine, Dr. B.R. Ambedkar State Institute of Medical Sciences, Mohali, Punjab, India. FAU - Lal, Dhruvendra AU - Lal D AD - Department of Community Medicine, Dr. B.R. Ambedkar State Institute of Medical Sciences, Mohali, Punjab, India. drdhruvlal@gmail.com. AD - Department of Paediatrics, Dr. B.R. Ambedkar State Institute of Medical Sciences, Mohali, Punjab, India. drdhruvlal@gmail.com. FAU - Sharma, Sahil AU - Sharma S AD - Department of Health and Family Welfare, Office of Directorate Health Services, Punjab, India. FAU - Goel, Ashish AU - Goel A AD - Department of Internal Medicine, Dr. B.R. Ambedkar State Institute of Medical Sciences, Mohali, Punjab, India. FAU - Bhardwaj, Anu AU - Bhardwaj A AD - Department of Community Medicine, Dr. B.R. Ambedkar State Institute of Medical Sciences, Mohali, Punjab, India. FAU - Nadda, Anuradha AU - Nadda A AD - Department of Community Medicine, Dr. B.R. Ambedkar State Institute of Medical Sciences, Mohali, Punjab, India. FAU - Kumar, Akshay AU - Kumar A AD - Department of Community Medicine, Dr. B.R. Ambedkar State Institute of Medical Sciences, Mohali, Punjab, India. FAU - Bharti, Bhavneet AU - Bharti B AD - Department of Health and Family Welfare, Office of Directorate Health Services, Punjab, India. FAU - Singh, Sukhbir AU - Singh S AD - Panjab University, Chandigarh, India. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260501 PL - England TA - Trials JT - Trials JID - 101263253 SB - IM MH - Adolescent MH - Female MH - Humans MH - *Adolescent Behavior MH - *Adolescent Health MH - Age Factors MH - Health Behavior MH - Health Knowledge, Attitudes, Practice MH - Healthy Lifestyle MH - India MH - Multicenter Studies as Topic MH - *Noncommunicable Diseases/prevention & control/epidemiology/psychology MH - Research Design MH - Risk Factors MH - *Risk Reduction Behavior MH - *School Health Services MH - Time Factors MH - Randomized Controlled Trials as Topic PMC - PMC13277109 OTO - NOTNLM OT - Adolescents OT - Behaviour change OT - Lifestyle OT - Non-communicable diseases OT - Primary prevention OT - Risk determinants OT - School-based intervention COIS- Declarations. Ethics approval and consent to participate 30: The study has been approved by the Institutional Ethics Committee at Dr B.R. Ambedkar State Institute of Medical Sciences, Mohali (No. AIMS/IEC-HR/2025/01, dated January 2, 2025) and prospectively registered with the Clinical Trials Registry of India (CTRI/2025/01/079797, dated January 30, 2025). Before enrolment, written parental consent and adolescent assent will be obtained by research staff. Study aims and procedures will be explained in age-appropriate language. All assessments will be conducted in private, with female students examined in the presence of another female staff member. Participants will be assigned unique IDs to ensure confidentiality, and data will be stored securely on password-protected systems accessible only to authorised study personnel. Consent for publication: Not applicable. Competing interests 7b: The authors declare that they have no competing interests. EDAT- 2026/05/01 06:34 MHDA- 2026/06/18 06:32 PMCR- 2026/05/01 CRDT- 2026/05/01 00:59 PHST- 2025/11/13 00:00 [received] PHST- 2026/04/11 00:00 [accepted] PHST- 2026/06/18 06:32 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 00:59 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 10.1186/s13063-026-09724-1 [pii] AID - 9724 [pii] AID - 10.1186/s13063-026-09724-1 [doi] PST - epublish SO - Trials. 2026 May 1;27(1):448. doi: 10.1186/s13063-026-09724-1. PMID- 42063118 OWN - NLM STAT- MEDLINE DCOM- 20260619 LR - 20260813 IS - 1742-4755 (Electronic) IS - 1742-4755 (Linking) VI - 23 IP - 1 DP - 2026 Apr 30 TI - Protocol of the Temporality, Eating and Metabolic health during PreconceptiOn (TEMPO) study in females with overweight and obesity: a prospective observational cohort nested within a preconception lifestyle intervention program. LID - 10.1186/s12978-026-02347-4 [doi] LID - 123 AB - INTRODUCTION: Human reproduction is tightly regulated by circadian and metabolic signals. However, the extent to which alterations in these systems affect fertility, especially in females with overweight or obesity who are at increased risk of infertility, remains poorly understood. This study, nested within the Healthy Early Life Moments in Singapore (HELMS) integrated lifestyle intervention program, aims to: (i) examine the associations between changes in circadian behavior and metabolic health indicators over a 3-month period and subsequent reproductive outcomes during a year of conception attempts, (ii) identify risk factors associated with these changes, and (iii) elucidate the biological mechanisms underpinning these relationships in females attempting to conceive. METHODS: This prospective observational cohort study will enroll 283 females with a BMI of 25-40 kg/m(2) participating in the HELMS program at KK Women's and Children's Hospital, Singapore. Participants will be followed for one year as they attempt to conceive. At baseline and at the 3-month mark, circadian behavior will be assessed using validated questionnaires, tracking diaries, and digital wearables. Metabolic health will be evaluated through anthropometry, body fat composition, a metabolic syndrome score, and an insulin resistance index. Blood samples will be collected to analyze metabolic biomarkers and gene expression levels. We will use modified Poisson regression models to examine associations with the clinical pregnancy rate (primary outcome) and discrete-time proportional hazards models to estimate associations with fecundability (secondary outcome) within one year of conception attempts. DISCUSSION: This study is pivotal for identifying potential novel modifiable risk factors to address low fertility rates. Insights from this research will generate hypotheses for interventions designed to enhance preconception care. By screening and managing circadian behaviors and metabolic profiles among females with overweight and obesity, these strategies may benefit those experiencing unexplained infertility. Ultimately, this approach could foster a shift towards a more holistic and patient-centered model of reproductive healthcare. CI - (c) 2026. The Author(s). FAU - Loy, See Ling AU - Loy SL AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, 229899, Singapore. loyseeling@duke-nus.edu.sg. AD - Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. loyseeling@duke-nus.edu.sg. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. loyseeling@duke-nus.edu.sg. FAU - Ku, Chee Wai AU - Ku CW AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, 229899, Singapore. AD - Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Pek, Jun Wei AU - Pek JW AD - Temasek Life Sciences Laboratory, Singapore, Singapore. AD - Department of Biological Sciences, National University of Singapore, Singapore, Singapore. FAU - Cheung, Yin Bun AU - Cheung YB AD - Program in Health Services & Systems Research and Centre for Quantitative Medicine, Duke-NUS Medical School, Singapore, Singapore. AD - Tampere Centre for Child, Adolescent and Maternal Health Research, Tampere University, Tampere, Finland. FAU - Leow, Melvin Khee Shing AU - Leow MKS AD - Endocrinology, Tan Tock Seng Hospital, Singapore, Singapore. AD - Institute for Human Development and Potential, Singapore Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. FAU - Cheng, Tuck Seng AU - Cheng TS AD - National Perinatal Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom. FAU - Chong, Mary Foong-Fong AU - Chong MF AD - Institute for Human Development and Potential, Singapore Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. AD - Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore. FAU - Godfrey, Keith M AU - Godfrey KM AD - Medical Research Council Lifecourse Epidemiology Centre, University of Southampton, Southampton, United Kingdom. AD - National Institute for Health Research Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton National Health Service Foundation Trust, Southampton, United Kingdom. FAU - Yap, Fabian AU - Yap F AD - Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. AD - Endocrinology Service, KK Women's and Children's Hospital, Singapore, Singapore. FAU - Chan, Jerry Kok Yen AU - Chan JKY AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore, 229899, Singapore. AD - Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. AD - SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore, Singapore. LA - eng GR - MOH-001537-01/National Medical Research Council/ PT - Journal Article PT - Observational Study DEP - 20260430 PL - England TA - Reprod Health JT - Reproductive health JID - 101224380 SB - IM MH - Humans MH - Female MH - Prospective Studies MH - *Obesity/complications/physiopathology MH - *Preconception Care/methods MH - *Overweight/complications/physiopathology MH - Pregnancy MH - Adult MH - Singapore MH - Life Style MH - Circadian Rhythm MH - Body Mass Index PMC - PMC13281643 OAB - Human reproduction is shaped by the body's internal clock and metabolism, but it is not yet clear how changes in these systems affect fertility, particularly in women with overweight or obesity, who are at higher risk of infertility. This study, part of the Healthy Early Life Moments in Singapore (HELMS) program, aims to better understand these links. A total of 283 women with a body mass index between 25 and 40 kg/m(2) will be recruited at KK Women's and Children's Hospital, Singapore, and followed for one year while trying to conceive. At baseline and 3-month follow-up, participants' daily routines, including the timing of eating and sleep, will be recorded using questionnaires, diaries, and wearable devices. Their metabolic health will be assessed through body fat, waist size, blood sugar control, and blood tests for biomarkers and gene activity. Researchers will analyze how changes in these patterns relate to the chances of becoming pregnant and the time it takes to conceive. This work is important because it may reveal lifestyle and health factors that can be modified to improve fertility. The findings will help shape new approaches to support women before pregnancy. By addressing daily routines such as meal timing and sleep, alongside metabolic health, this study may offer practical strategies for women struggling to conceive without a clear medical cause identified through standard reproductive investigations. In the long run, this approach could lead to more personalized and supportive fertility care that looks beyond medical treatment to the whole person. OABL- eng OTO - NOTNLM OT - Behavior OT - Chronobiology OT - Chrononutrition OT - Clock gene OT - Female reproductive health OT - Meal timing OT - Preconception OT - Sleep COIS- Declarations. Ethics approval and consent to participate: The HELMS trial was registered at clinicaltrial.gov NCT 05207059 on January 26, 2022. The Centralized Institutional Review Board of SingHealth (2021/2247) approved both the initial HELMS protocol and additional data collection for this TEMPO study. The study is conducted in accordance with the ethical principles outlined in the Declaration of Helsinki. Written informed consent is obtained from all participants before they are included in the study. Consent for publication: Not applicable. Competing interests: Dr Godfrey reported being part of an academic consortium that received research funding from Bayer, BenevolentAI Bio Ltd, Nestec, and Danone outside the submitted work. No other disclosures were reported. EDAT- 2026/05/01 06:34 MHDA- 2026/06/19 06:33 PMCR- 2026/04/30 CRDT- 2026/05/01 00:56 PHST- 2025/09/04 00:00 [received] PHST- 2026/04/25 00:00 [accepted] PHST- 2026/06/19 06:33 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 00:56 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - 10.1186/s12978-026-02347-4 [pii] AID - 2347 [pii] AID - 10.1186/s12978-026-02347-4 [doi] PST - epublish SO - Reprod Health. 2026 Apr 30;23(1):123. doi: 10.1186/s12978-026-02347-4. PMID- 42062960 OWN - NLM STAT- MEDLINE DCOM- 20260619 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Apr 30 TI - IL-33 associates with type 2 burden and lung function in paediatric asthma, alongside exploratory IL-33-linked lipid changes. LID - 10.1186/s12887-026-06947-8 [doi] LID - 578 AB - BACKGROUND: Interleukin-33 (IL-33) is an epithelial alarmin positioned upstream of type 2 (T2) inflammation, yet its clinical correlates and systemic molecular context in paediatric asthma remain incompletely defined. We investigated whether circulating IL-33 is associated with objective disease-burden measures and whether IL-33 elevation co-occurs with exploratory plasma lipid differences. METHODS: In a paediatric case-control cohort (August 2023-June 2025; asthma n = 60, controls n = 60), plasma IL-33 was quantified by ELISA and related to spirometry (FEV1, FEV1/FVC, PEF) and T2 markers (blood eosinophils, total IgE, FeNO). Associations were assessed using correlation analyses and multivariable linear regression treating IL-33 as a continuous exposure (mean-centred ln[IL-33]) with adjustment for age, sex, BMI, and group, plus an Age x IL-33 interaction. ROC analyses were used to describe case-control discrimination within the cohort. Untargeted plasma lipidomics was performed in an exploratory discovery subset (asthma n = 8, controls n = 8) to define differential lipids, IL-33-anchored lipid patterns, and an exploratory six-lipid IL-33-linked score; score-trait associations were evaluated as exploratory analyses with group residualization. RESULTS: Compared with controls, children with asthma showed worse lung function and higher T2 burden (all P < 0.001), alongside higher IL-33 (107.1 +/- 38.5 vs. 52.4 +/- 21.6 pg/mL; P < 0.001). Across the cohort, IL-33 correlated inversely with lung function (FEV1 r = - 0.652; FEV1/FVC r = - 0.585; PEF r = - 0.683; all P < 0.001) and positively with T2 markers (eosinophils r = 0.534; IgE r = 0.583; FeNO r = 0.622; all P < 0.001). In multivariable models, ln(IL-33) remained significantly associated with each outcome after adjustment for age, sex, BMI, and group status, whereas the Age x IL-33 interaction was not significant (all P > 0.05). IL-33 showed case-control discrimination within the cohort (AUC 0.92; cut-off 75.4 pg/mL). In the exploratory lipidomics subset, PCA suggested group separation, although this should be interpreted cautiously given the small sample size. Differential lipids were dominated by glycerophospholipids (66.67%), followed by sphingolipids (18.1%). Exploratory IL-33-anchored analyses identified provisional glycerophospholipid/cardiolipin-positive and sphingomyelin-negative lipid patterns. The exploratory IL-33-linked lipid score showed high apparent discrimination within the discovery subset (AUC 0.96; LOOCV AUC 0.97) and, after group residualization, remained directionally associated with lung function and T2 markers. CONCLUSION: In this paediatric case-control cohort, circulating IL-33 was elevated in children with asthma and was significantly associated with objective airflow limitation and systemic type 2 inflammatory burden. Higher IL-33 levels also co-occurred with exploratory plasma lipid differences. These findings should be interpreted as adjusted associations observed within a cross-sectional case-control design and require longitudinal and external validation before any broader biomarker or clinical application can be considered. CI - (c) 2026. The Author(s). FAU - Yu, Yingtan AU - Yu Y AD - Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. AD - Department of Pediatrics, Affiliated Hospital of Jiangnan University, No. 1000 Hefeng Road, Binhu District, Wuxi, Jiangsu, 214122, P.R. China. FAU - Liu, Wanying AU - Liu W AD - Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. AD - Department of Pediatrics, Affiliated Hospital of Jiangnan University, No. 1000 Hefeng Road, Binhu District, Wuxi, Jiangsu, 214122, P.R. China. FAU - Li, Xinxu AU - Li X AD - Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. AD - Department of Pediatrics, Affiliated Hospital of Jiangnan University, No. 1000 Hefeng Road, Binhu District, Wuxi, Jiangsu, 214122, P.R. China. FAU - Chang, Tianzhi AU - Chang T AD - Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. FAU - Tong, Xiao AU - Tong X AD - Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu, China. 9862018033@jiangnan.edu.cn. AD - Department of Pediatrics, Affiliated Hospital of Jiangnan University, No. 1000 Hefeng Road, Binhu District, Wuxi, Jiangsu, 214122, P.R. China. 9862018033@jiangnan.edu.cn. LA - eng PT - Journal Article DEP - 20260430 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 0 (Interleukin-33) RN - 0 (IL33 protein, human) RN - 0 (Biomarkers) RN - 0 (Lipids) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Humans MH - *Interleukin-33/blood MH - Child MH - Case-Control Studies MH - *Asthma/blood/physiopathology MH - Male MH - Female MH - Biomarkers/blood MH - *Lipids/blood MH - Adolescent MH - Immunoglobulin E/blood MH - Respiratory Function Tests MH - Lipidomics MH - Spirometry PMC - PMC13281470 OTO - NOTNLM OT - Glycerophospholipid remodelling OT - IL-33-lipid score OT - Interleukin-33 OT - Paediatric asthma COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Medical Ethics Committee of the Affiliated Hospital of Jiangnan University (approval number: LS2022112). The study was conducted in accordance with the Declaration of Helsinki and applicable local regulations. Written informed consent was obtained from the parents or legal guardians of all participants, and assent was obtained from children when appropriate. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/05/01 06:34 MHDA- 2026/06/19 06:32 PMCR- 2026/04/30 CRDT- 2026/05/01 00:47 PHST- 2026/02/27 00:00 [received] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/06/19 06:32 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 00:47 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - 10.1186/s12887-026-06947-8 [pii] AID - 6947 [pii] AID - 10.1186/s12887-026-06947-8 [doi] PST - epublish SO - BMC Pediatr. 2026 Apr 30;26(1):578. doi: 10.1186/s12887-026-06947-8. PMID- 42062818 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1365-277X (Electronic) IS - 0952-3871 (Print) IS - 0952-3871 (Linking) VI - 39 IP - 3 DP - 2026 Jun TI - Nutrition Literacy, Hydration Awareness and Food Label Use in School Populations: A Cross-Sectional Study of Students and Teachers Across European Contexts. PG - e70258 LID - 10.1111/jhn.70258 [doi] LID - e70258 AB - BACKGROUND: Nutrition literacy is increasingly recognised as a key determinant of dietary behaviours and long-term public health outcomes. Schools represent strategic settings for strengthening nutrition literacy-related competencies, including hydration awareness and food label use, yet comparative. However, descriptive cross-country evidence across European school contexts remains limited. METHODS: A cross-sectional, school-based survey was conducted among 432 students (aged 11-16 years) and 108 teachers across five European contexts (Italy, Germany, Cyprus, Serbia and Guadeloupe [France]). Culturally adapted questionnaires developed within the Erasmus+ GARDENS project assessed predefined domains of nutrition knowledge (food groups, macronutrient functions, fibre, vitamins and minerals), hydration awareness, food label use and selected sustainability-related concepts. Knowledge items were coded dichotomously (correct/incorrect), and behavioural indicators were analysed descriptively. Cross-country comparisons were exploratory. RESULTS: Teachers in Germany and Italy reported higher levels of hydration awareness (> 90%) and food label use (>/= 75%), whereas lower self-reported food label literacy was observed in Guadeloupe (48%). Among students, incorrect responses to nutrient-function items (defined as misconceptions) were observed in 40% of the overall sample, with higher proportions in Guadeloupe and Serbia. Cross-country variability was present across all assessed domains. CONCLUSIONS: Marked substantial descriptive differences in nutrition literacy knowledge, hydration awareness and food label use were observed across school populations in selected European contexts. These findings provide baseline public health evidence supporting the integration of nutrition literacy-particularly hydration and food labelling-into school-based health promotion strategies, with attention to equity and contextual factors. These findings provide baseline evidence to inform school-based health promotion strategies and highlight the relevance of contextual and equity-related considerations. Further research using validated instruments and inferential designs is warranted. CI - (c) 2026 The Author(s). Journal of Human Nutrition and Dietetics published by John Wiley & Sons Ltd on behalf of British Dietetic Association. FAU - Coradduzza, Donatella AU - Coradduzza D AUID- ORCID: 0000-0002-8978-0490 AD - Department of Biomedical Sciences, University of Sassari, Sassari, Italy. FAU - Boccuzzi, Giannagelo AU - Boccuzzi G AD - Mine Vaganti NGO, Sassari, Italy. FAU - Masi, Giancarlo AU - Masi G AD - Mine Vaganti NGO, Sassari, Italy. FAU - Porstner, Christian AU - Porstner C AD - NGO NEST Berlin e.V., Berlin, Germany. FAU - Dube, Raphael AU - Dube R AD - Universite des Antilles, Guadeloupe, France. FAU - Nikolaou, Nikolas AU - Nikolaou N AD - Department of Education, University of Cyprus, Nicosia, Cyprus. FAU - Sedda, Stefania AU - Sedda S AD - Department of Biomedical Sciences, University of Sassari, Sassari, Italy. FAU - Merdovic, Maja AU - Merdovic M AD - Institute for Public Health of Serbia, Belgrade, Serbia. FAU - Medici, Serenella AU - Medici S AD - Department of Chemical, Physical, Mathematical and Natural Sciences, University of Sassari, Sassari, Italy. FAU - Carru, Ciriaco AU - Carru C AUID- ORCID: 0000-0002-6985-4907 AD - Department of Biomedical Sciences, University of Sassari, Sassari, Italy. FAU - Solinas, Roberto AU - Solinas R AD - Mine Vaganti NGO, Sassari, Italy. FAU - Pirina, Maria Grazia AU - Pirina MG AD - Mine Vaganti NGO, Sassari, Italy. LA - eng GR - 2023-1-FR01-KA220-SCH-000160068/Erasmus+ Program/ PT - Journal Article PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Food Labeling/statistics & numerical data MH - *Health Knowledge, Attitudes, Practice MH - Schools MH - *Health Literacy/statistics & numerical data MH - *Students/statistics & numerical data/psychology MH - Child MH - Adolescent MH - Male MH - Female MH - Europe MH - *School Teachers/statistics & numerical data/psychology MH - Surveys and Questionnaires MH - European People MH - *Drinking MH - Serbia PMC - PMC13133250 OTO - NOTNLM OT - food labelling OT - health promotion OT - nutrition literacy, hydration OT - nutrition literacy, public health nutrition OT - school health OT - sustainability COIS- The authors declare no conflicts of interest. EDAT- 2026/05/01 06:34 MHDA- 2026/05/01 06:35 PMCR- 2026/05/01 CRDT- 2026/05/01 00:03 PHST- 2026/04/08 00:00 [revised] PHST- 2026/01/23 00:00 [received] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/05/01 06:35 [medline] PHST- 2026/05/01 06:34 [pubmed] PHST- 2026/05/01 00:03 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - JHN70258 [pii] AID - 10.1111/jhn.70258 [doi] PST - ppublish SO - J Hum Nutr Diet. 2026 Jun;39(3):e70258. doi: 10.1111/jhn.70258. PMID- 42062552 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260430 LR - 20260813 IS - 2730-664X (Electronic) IS - 2730-664X (Linking) VI - 6 IP - 1 DP - 2026 Apr 30 TI - Measuring gross motor skills in African children using the PERF-FIT. LID - 10.1038/s43856-026-01592-9 [doi] LID - 258 AB - BACKGROUND: Africa is facing a rising prevalence of non-communicable diseases (NCDs), driven by shifts in lifestyle and dietary habits. Children with delays in motor coordination are less likely to participate in physical activity, active play, and sports, placing them at increased risk for obesity, reduced physical fitness, and cardiovascular diseases. Existing motor performance tests for school-aged children were not designed for African populations and lack culturally valid normative data. METHODS: As part of an African-led initiative, the PERFormance and FITness test battery (PERF-FIT) was developed to assess motor performance and motor skill-related physical fitness in children aged 6-12 years. The PERF-FIT test battery is open-source, contextually relevant, and tailored for low-resource settings. This study involved the collection of motor performance data from a large sample of African children to establish age- and sex-specific normative values. RESULTS: This study generates normative data for motor skills in African children aged 6-12 years (n = 2604), stratified by age and sex. These norms complement the previously validated psychometric properties of the PERF-FIT, confirming its reliability and applicability across diverse African contexts. CONCLUSIONS: The PERF-FIT test battery provides a culturally appropriate and psychometrically sound tool for assessing motor performance in African children. It serves as a valuable resource for clinicians, educators, and policymakers to monitor motor skill related physical fitness and detect motor delays in children aged 6-12 years in African countries. CI - (c) 2026. The Author(s). FAU - Smits-Engelsman, Bouwien AU - Smits-Engelsman B AUID- ORCID: 0000-0003-0632-3276 AD - Physical Activity, Sport and Recreation (PhASRec), Faculty Health Sciences, North-West University, Potchefstroom, South Africa. bouwiensmits@hotmail.com. AD - Department of Health & Rehabilitation Sciences, Faculty of Health Sciences, The University of Cape Town, Cape Town, South Africa. bouwiensmits@hotmail.com. FAU - Coetzee, Dane AU - Coetzee D AUID- ORCID: 0000-0002-7166-8353 AD - Physical Activity, Sport and Recreation (PhASRec), Faculty Health Sciences, North-West University, Potchefstroom, South Africa. FAU - Doe-Asinyo, Rosemary Xorlanyo AU - Doe-Asinyo RX AUID- ORCID: 0000-0003-1766-8173 AD - Department of Occupational Therapy, College of Health Sciences, University of Ghana, Accra, Ghana. FAU - Ituen, Oluwakemi Adebukola AU - Ituen OA AUID- ORCID: 0009-0004-2241-9205 AD - Department of Physiotherapy, University of Uyo Teaching Hospital, Uyo, Akwa Ibom state, Nigeria. FAU - Farhat, Faical AU - Farhat F AUID- ORCID: 0009-0009-7765-7944 AD - Research Laboratory 'NeuroPediatrie' (LR19ES15), Sfax Medical School, University of Sfax, Sfax, Tunisia. AD - Research Laboratory: Education, Motricity, Sport and Health, EM2S, LR19JS01, High Institute of Sport and Physical Education of Sfax, Sfax, Tunisia. FAU - Melaku Dubale, Yabsra AU - Melaku Dubale Y AUID- ORCID: 0009-0007-5251-7553 AD - Department of Nutrition and Dietetics, Faculty of Public Health, Health Institute, Jimma University, Jimma, Ethiopia. AD - Rehabilitation Research Centre - REVAL, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium. FAU - Verbecque, Evi AU - Verbecque E AUID- ORCID: 0000-0001-8116-1620 AD - Department of Nutrition and Dietetics, Faculty of Public Health, Health Institute, Jimma University, Jimma, Ethiopia. LA - eng PT - Journal Article DEP - 20260430 PL - England TA - Commun Med (Lond) JT - Communications medicine JID - 9918250414506676 PMC - PMC13133362 OAB - This study aimed to make a motor performance test that is suitable for African children aged 6 to 12 years. Many existing tests were developed in other regions and do not reflect the abilities or context of African children. Researchers of an African-led initiative developed the PERFormance and FITness test battery (PERF-FIT), which is free to use and designed for schools, clinics and healthcare workers in low-resource settings. The study describes how data were collected from 2604 children to create age- and sex-specific norms. These results help professionals understand what typical motor skills look like in African children. This tool can support early identification of children at risk for motor delays and health problems based on low motor fitness. OABL- eng COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/05/01 00:32 MHDA- 2026/05/01 00:33 PMCR- 2026/04/30 CRDT- 2026/04/30 23:28 PHST- 2025/06/03 00:00 [received] PHST- 2026/04/08 00:00 [accepted] PHST- 2026/05/01 00:33 [medline] PHST- 2026/05/01 00:32 [pubmed] PHST- 2026/04/30 23:28 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - 10.1038/s43856-026-01592-9 [pii] AID - 1592 [pii] AID - 10.1038/s43856-026-01592-9 [doi] PST - epublish SO - Commun Med (Lond). 2026 Apr 30;6(1):258. doi: 10.1038/s43856-026-01592-9. PMID- 42062348 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Apr 30 TI - Feasibility of forecasting self-injurious behavior among autistic youth using wearable sensors and machine learning models. LID - 10.1038/s41598-026-50079-z [doi] LID - 20203 AB - Self-injurious behavior (SIB) is a substantial clinical challenge for many individuals on the autism spectrum, and support strategies are often only reactive. Forecasting of SIB could enable timely support, especially using wearable sensors, but its feasibility is not well understood. We evaluated SIB forecasting using a previously collected dataset (n = 9) comprising motion and physiological data. We compared the performance of four machine learning models-Random Forest, AdaBoost.M2, Long Short-Term Memory (LSTM), and a Double-Stacked LSTM-across five forecast horizons (3s to 120s) and three feature sets: Motion-Only (from accelerometers), Physiological-Only (e.g., heart rate, skin conductance), and Combined. Performance was measured with a range of metrics, using Leave-One-Subject-Out cross-validation. We found a significant main effect of forecast horizon on the Area Under the Precision-Recall Curve; performance rose from near-chance at short horizons to having median scores above chance at one minute or longer. While aggregated results showed no significant differences between models or feature sets, subject-level analysis suggested predictive feasibility and that the optimal model configuration were highly person-specific. Our findings demonstrate that forecasting using wearable sensor data is feasible, but the substantial performance variability highlights a critical need for person-specific approaches to enable the development of clinically useful, proactive support systems. CI - (c) 2026. The Author(s). FAU - Kim, Sunwook AU - Kim S AD - Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, VA, USA. sunwook@vt.edu. FAU - Cantin-Garside, Kristine D AU - Cantin-Garside KD AD - Global Digital Health Strategy, Johnson & Johnson, Raritan, NJ, USA. FAU - Nussbaum, Maury A AU - Nussbaum MA AD - Department of Industrial and Systems Engineering, Virginia Tech, Blacksburg, VA, USA. LA - eng PT - Journal Article DEP - 20260430 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Wearable Electronic Devices MH - *Self-Injurious Behavior/diagnosis MH - *Machine Learning MH - Feasibility Studies MH - Predictive Learning Models MH - Long Short Term Memory MH - *Autistic Disorder/complications MH - Forecasting/methods MH - Prediction Algorithms MH - Child MH - Female MH - Adolescent MH - Random Forest MH - Boosting Machine Learning Algorithms PMC - PMC13323699 OTO - NOTNLM OT - Autism spectrum disorder OT - Biosensors OT - Challenging behavior OT - Neurodivergence OT - Preventive intervention OT - Remote monitoring COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/05/01 00:32 MHDA- 2026/07/02 00:34 PMCR- 2026/04/30 CRDT- 2026/04/30 23:21 PHST- 2025/09/11 00:00 [received] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/07/02 00:34 [medline] PHST- 2026/05/01 00:32 [pubmed] PHST- 2026/04/30 23:21 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - 10.1038/s41598-026-50079-z [pii] AID - 50079 [pii] AID - 10.1038/s41598-026-50079-z [doi] PST - epublish SO - Sci Rep. 2026 Apr 30;16(1):20203. doi: 10.1038/s41598-026-50079-z. PMID- 42062102 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 1539-2880 (Electronic) IS - 0730-0832 (Linking) VI - 45 IP - 2 DP - 2026 Apr 1 TI - A Quality Improvement Project to Increase Breastfeeding Rates in the NICU. PG - 132-141 LID - 10.1891/NN-2025-0054 [doi] AB - The Baby-Friendly Hospital Initiative strives to increase exclusive breastfeeding rates. Research findings suggest that NICU nurses' actions and support may be a key factor in increasing breastfeeding rates. Our needs and feasibility assessment identified a NICU lacking a NICU-specific breastfeeding policy, and a review of the electronic health record (EHR) showed nurses did not assist patients with breastfeeding. We conducted a quality improvement project that included the creation of a NICU-specific breastfeeding policy, educational inservices, and real-time coaching for nurses. Additionally, pre-post questionnaires were administered to the nurses, and a review of the EHR was performed to assess nurse-assisted breastfeeding attempts pre and post project implementation. Thirty-six (80%) nurses attended the inservice. Almost two thirds of nurses (63%) had adequate breastfeeding knowledge prior to the inservice. Nurses' knowledge gained from the inservice was not statistically significant from pre/post implementation of the project (t = 0.48, p = 0.32). We identified 11 nurse-assisted breastfeeding attempts in our 10-day review of the NICU EHR after project implementation. This result was compared with zero nurse-assisted attempts in our EHR review prior to this project. We conclude that a multimodal approach to support breastfeeding in the NICU may be beneficial to increase breastfeeding rates by ensuring nurses have the knowledge and skills to promote breastfeeding. CI - (c) 2026 Springer Publishing Company. FAU - Strickland, Leesa L AU - Strickland LL AD - Marcella Niehoff School of Nursing, Loyola University Chicago, Maywood, IL, USA lstrickland1@luc.edu. FAU - Young, Lindsey C AU - Young LC AD - Loyola University Medical Center, Maywood, IL, USA. FAU - Garfield, Lindsey AU - Garfield L AD - Marcella Niehoff School of Nursing, Loyola University Chicago, Maywood, IL, USA. LA - eng PT - Journal Article PL - United States TA - Neonatal Netw JT - Neonatal network : NN JID - 8503921 SB - IM MH - Humans MH - *Breast Feeding/statistics & numerical data/psychology MH - *Quality Improvement MH - *Intensive Care Units, Neonatal/standards MH - Infant, Newborn MH - Female MH - *Neonatal Nursing/standards MH - Adult MH - *Health Promotion/methods MH - *Nurses, Neonatal MH - Nurse's Role OTO - NOTNLM OT - NICU care OT - evidence-based practice OT - feeding/nutrition OT - quality improvement EDAT- 2026/05/01 00:31 MHDA- 2026/05/01 00:32 CRDT- 2026/04/30 21:42 PHST- 2026/05/01 00:32 [medline] PHST- 2026/05/01 00:31 [pubmed] PHST- 2026/04/30 21:42 [entrez] AID - 45/2/132 [pii] AID - 10.1891/NN-2025-0054 [doi] PST - ppublish SO - Neonatal Netw. 2026 Apr 1;45(2):132-141. doi: 10.1891/NN-2025-0054. PMID- 42062069 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260814 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 10 IP - 1 DP - 2026 Apr 30 TI - Challenges during clinical lactation studies investigating medicines exposure: experiences from the UmbrelLACT study - a contribution from the ConcePTION project. LID - 10.1136/bmjpo-2026-004603 [doi] LID - e004603 AB - BACKGROUND: Clinical lactation studies are valuable to guide pharmacotherapy during breastfeeding, but are not easy to conduct. This paper reports on challenges and mitigation strategies while conducting the UmbrelLACT study, a prospective observational lactation study. METHODS: The UmbrelLACT study includes breastfeeding women taking a relevant medicine (eg, absence of safety evidence during lactation) and after feasibility verification (eg, access to bioanalytical assay). Participants collect human milk samples at home over 24 hours. Optionally, maternal and infant blood samples are collected, together with self-reported questionnaires on clinical maternal and child variables. Medicine concentrations and estimated infant exposure (eg, daily and relative infant dose) are determined. RESULTS: Regarding informed consent, study objectives should be carefully phrased to prevent pharmacotherapy avoidance due to a lack of safety information. On sample collection, the study team should provide all necessary materials if not available at home, including an electric breast pump. Due to the milk expressions over 24 hours, the infant might miss soothing moments. This can be mitigated by giving the breast after expressing the milk for study purposes, creating alternative soothing moments. Sample handling might be complicated by additional steps needed for certain compounds. A bioanalysis method should be available or developed for the milk matrix. Finding the assay might be challenging, but it can be facilitated by a network of specialised labs. In the UmbrelLACT study, pharmacokinetic values are collected fragmentarily. This results in the need for data pooling with data from the literature. In contrast, at-home sampling and multidisciplinary collaboration are clear strengths. CONCLUSIONS: It is feasible to tailor the approach to each participant and compound, to minimise the burden on the patient and their family. While there are limitations related to the pragmatic design, the opportunities of this lactation study outweigh the challenges to result in clinically significant scientific observations. TRIAL REGISTRATION NUMBER: NCT06042803. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Van Neste, Martje AU - Van Neste M AUID- ORCID: 0000-0002-0424-450X AD - Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. AD - Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - L-C&Y, KU Leuven Child & Youth institute, KU Leuven, Leuven, Belgium. AD - Teratology Information Service, Netherlands Pharmacovigilance Centre Lareb, 's Hertogenbosch, The Netherlands. FAU - Nauwelaerts, Nina AU - Nauwelaerts N AD - Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. AD - ESQlabs GmbH, Saterland, Germany. FAU - Ceulemans, Michael AU - Ceulemans M AUID- ORCID: 0000-0002-4130-5869 AD - Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. AD - L-C&Y, KU Leuven Child & Youth institute, KU Leuven, Leuven, Belgium. AD - Research Foundation Flanders (FWO), Brussels, Belgium. FAU - Van Calsteren, Kristel AU - Van Calsteren K AD - Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium. FAU - Eerdekens, An AU - Eerdekens A AD - Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium. FAU - Annaert, Pieter AU - Annaert P AD - Drug Delivery and Disposition, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. AD - BioNotus CommV, Niel, Belgium. FAU - Smits, Anne AU - Smits A AD - Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - L-C&Y, KU Leuven Child & Youth institute, KU Leuven, Leuven, Belgium. AD - Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium. FAU - Allegaert, Karel AU - Allegaert K AUID- ORCID: 0000-0001-9921-5105 AD - Clinical Pharmacology and Pharmacotherapy, Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium allegaertkarel@hotmail.com. AD - Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - L-C&Y, KU Leuven Child & Youth institute, KU Leuven, Leuven, Belgium. AD - Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, Netherlands. LA - eng SI - ClinicalTrials.gov/NCT06042803 PT - Journal Article PT - Observational Study PT - Review DEP - 20260430 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Female MH - *Lactation MH - *Breast Feeding MH - *Milk, Human/chemistry MH - Prospective Studies MH - Infant, Newborn MH - Infant MH - Adult PMC - PMC13141100 OTO - NOTNLM OT - Breastfeeding OT - Infant OT - Neonatology OT - Pharmacology COIS- Competing interests: KA is deputy editor in chief of the journal BMJ Paediatrics Open journal, but was not involved in the editorial handling of the paper. All other authors have no competing interests to declare. EDAT- 2026/05/01 00:32 MHDA- 2026/05/01 00:33 PMCR- 2026/04/30 CRDT- 2026/04/30 21:32 PHST- 2026/02/06 00:00 [received] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/05/01 00:33 [medline] PHST- 2026/05/01 00:32 [pubmed] PHST- 2026/04/30 21:32 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - 10.1136/bmjpo-2026-004603 [pii] AID - bmjpo-2026-004603 [pii] AID - 10.1136/bmjpo-2026-004603 [doi] PST - epublish SO - BMJ Paediatr Open. 2026 Apr 30;10(1):e004603. doi: 10.1136/bmjpo-2026-004603. PMID- 42061840 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260905 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Apr 17 TI - Combining Digital Cognitive Behavioral Therapy With Mindfulness Training for Binge Eating Disorder: Protocol for a Feasibility Trial. PG - e91761 LID - 10.2196/91761 [doi] LID - e91761 AB - BACKGROUND: Cognitive behavioral therapy (CBT) is the most effective treatment for binge eating disorder (BED) but is limited by modest efficacy and low reach of in-person delivery. Combining mindfulness training with CBT could enhance efficacy by targeting emotion dysregulation, a key factor in BED that CBT does not adequately target. Digital delivery can enhance the reach of treatment. Accordingly, we developed CBT-based Mindful Courage, a 16-session digital intervention combining CBT and mindfulness training for BED. OBJECTIVE: The aim of this study is to conduct a pilot randomized controlled trial to evaluate the feasibility (intervention and assessment completion) and acceptability (usability, overall satisfaction, engagement, visual appeal of content, understandability of program content, desire to continue the program, perceived skill acquisition, perceived confidence in implementing skills, and perceived helpfulness) of CBT-based Mindful Courage. We will also evaluate changes in outcomes (binge eating frequency, eating disorder symptoms, clinical impairment, and depression symptoms) and mechanisms (emotion dysregulation, dietary overrestriction, and trait mindfulness). METHODS: This is a parallel-group, single-blinded, randomized controlled trial with a 1:1 allocation ratio. It will be conducted from November 2025 to November 2026, with study assessments at baseline, midtreatment, end-of-treatment, and 2-month follow-up. We will recruit a volunteer sample of adults with BED (N=40) aged 18 to 75 years via online advertisements. Exclusion criteria include a BMI <18.5, current anorexia or bulimia nervosa, and current treatment for BED or weight loss. Participants will be randomly allocated to an active control that includes coached self-monitoring (self-monitoring of food intake in Recovery Record and coaching calls by a research assistant) or to CBT-based Mindful Courage+coached self-monitoring. Both conditions will have a duration of 18 weeks. All study sessions will take place over Zoom. RESULTS: The study was funded in April 2023. Data collection began in November 2025, and we anticipate recruitment to be completed by November 2026. Results are expected to be analyzed by May 2027 and published by May 2028. CONCLUSIONS: This will be an important first step in creating a scalable and efficacious treatment for BED. TRIAL REGISTRATION: ClinicalTrials.gov NCT07212673; https://clinicaltrials.gov/study/NCT07212673. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/91761. CI - (c)Margaret Sala, Corey Roos, Dante Ascarrunz, Casey M Stern, Jonathan Bricker, Jonathan M Feldman, Cheri Levinson, Mihaela Aslan, Jennifer L Hay, Hedy Kober. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 17.04.2026. FAU - Sala, Margaret AU - Sala M AUID- ORCID: 0000-0002-1560-649X AD - Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, United States. FAU - Roos, Corey AU - Roos C AUID- ORCID: 0000-0002-0086-770X AD - Department of Psychiatry, School of Medicine, Yale University, New Haven, CT, United States. FAU - Ascarrunz, Dante AU - Ascarrunz D AUID- ORCID: 0009-0004-0641-456X AD - Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, United States. AD - Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, United States. FAU - Stern, Casey M AU - Stern CM AUID- ORCID: 0000-0002-0127-8667 AD - Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, United States. FAU - Bricker, Jonathan AU - Bricker J AUID- ORCID: 0000-0002-5694-8795 AD - Division of Public Health Sciences, Fred Hutch Cancer Center, Seattle, WA, United States. AD - Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, United States. FAU - Feldman, Jonathan M AU - Feldman JM AUID- ORCID: 0000-0002-7326-3026 AD - Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY, United States. AD - Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY, United States. FAU - Levinson, Cheri AU - Levinson C AUID- ORCID: 0000-0003-2359-5206 AD - Department of Psychological and Brain Sciences, University of Louisville, Louisville, KY, United States. FAU - Aslan, Mihaela AU - Aslan M AUID- ORCID: 0000-0002-5041-010X AD - Department of Internal Medicine, School of Medicine, Yale University, New Haven, CT, United States. AD - VA Connecticut Healthcare System, West Haven, CT, United States. FAU - Hay, Jennifer L AU - Hay JL AUID- ORCID: 0000-0002-3492-9331 AD - Department of Psychiatry and Behavioral Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, United States. FAU - Kober, Hedy AU - Kober H AUID- ORCID: 0000-0001-9893-1046 AD - Department of Psychology, University of California, Berkeley, Berkeley, CA, United States. LA - eng SI - ClinicalTrials.gov/NCT07212673 GR - K23 AT012126/AT/NCCIH NIH HHS/United States PT - Clinical Trial Protocol PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260417 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Binge-Eating Disorder/therapy/psychology MH - *Cognitive Behavioral Therapy/methods MH - Feasibility Studies MH - *Mindfulness/methods MH - Pilot Projects MH - Single-Blind Method MH - Treatment Outcome MH - Randomized Controlled Trials as Topic PMC - PMC13135158 OTO - NOTNLM OT - binge eating disorder OT - cognitive behavioral therapy OT - digital OT - eating disorder OT - mindfulness-based intervention OT - mindfulness-based therapy COIS- Conflicts of Interest: None declared. EDAT- 2026/05/01 00:31 MHDA- 2026/05/01 00:32 PMCR- 2026/04/17 CRDT- 2026/04/30 19:53 PHST- 2026/01/19 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/03/10 00:00 [revised] PHST- 2026/05/01 00:32 [medline] PHST- 2026/05/01 00:31 [pubmed] PHST- 2026/04/30 19:53 [entrez] PHST- 2026/04/17 00:00 [pmc-release] AID - v15i1e91761 [pii] AID - 10.2196/91761 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Apr 17;15:e91761. doi: 10.2196/91761. PMID- 42061554 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260829 IS - 1559-2030 (Electronic) IS - 1551-7144 (Linking) VI - 166 DP - 2026 Jul TI - Design of the FRESH-A study: A randomized controlled trial evaluating telehealth parent-only treatment for autistic youth with overweight/obesity. PG - 108330 LID - S1551-7144(26)00116-3 [pii] LID - 10.1016/j.cct.2026.108330 [doi] AB - Autistic children have higher rates of overweight and obesity (OW/OB) compared to nonautistic children. Family-based behavioral treatment (FBT) is the standard of care for children with obesity and is delivered to both the parent and the child. Common autism characteristics, such as sensory sensitivities, social communication challenges, and behavioral rigidity, can limit the feasibility of providing FBT to both parent and child. Our team developed a parent-based treatment (PBT) model that is delivered only to the parent of an autistic child with OW/OB. Our published pilot data established the initial feasibility, acceptability and initial weight-loss efficacy of this program. This paper presents a protocol for an ongoing two-arm randomized controlled trial comparing the effect of a telehealth PBT program tailored for families with an autistic child (PBT-A) with a health education (HE) comparator on the child's weight over 18 months. We aim to recruit 150 families with an autistic child with OW/OB and randomize them to either six-months of telehealth PBT-A or HE treatment delivered to the parent only. The primary outcome is change in child body size, assessed by BMIz and percent of the 95th percentile, over the 18 months of the study. Secondary outcomes include parent BMI, dietary intake for both parent and child, child mealtime behavior, physical activity levels, parenting style, and parental self-efficacy. This ongoing study may provide a scalable, cost-effective intervention for families with an autistic child with OW/OB. Clinical trials # NCT05741840. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Boutelle, Kerri N AU - Boutelle KN AD - Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA; Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA; Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA. Electronic address: kboutelle@health.ucsd.edu. FAU - Eichen, Dawn M AU - Eichen DM AD - Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA. FAU - Martinez, Kassandra AU - Martinez K AD - Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA; San Diego State University/University of California, San Diego Joint Doctoral Program in Clinical Psychology, 6363 Alvarado Court, Suite 103, San Diego, CA 92120, USA. FAU - Pinson, Claire K AU - Pinson CK AD - Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA; San Diego State University/University of California, San Diego Joint Doctoral Program in Public Health, 5500 Campanile Drive, Hardy Tower room 119, San Diego, CA 92182-4162, USA. FAU - Strong, David R AU - Strong DR AD - Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA. FAU - Reed, Kristie L AU - Reed KL AD - Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA. FAU - Akshoomoff, Natacha AU - Akshoomoff N AD - Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA. FAU - Rhee, Kyung E AU - Rhee KE AD - Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA. FAU - Brookman-Frazee, Lauren AU - Brookman-Frazee L AD - Department of Psychiatry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92037, USA. LA - eng SI - ClinicalTrials.gov/NCT05741840 GR - R01 HD106991/HD/NICHD NIH HHS/United States GR - UL1 TR001442/TR/NCATS NIH HHS/United States PT - Clinical Trial Protocol PT - Journal Article DEP - 20260428 PL - United States TA - Contemp Clin Trials JT - Contemporary clinical trials JID - 101242342 SB - IM MH - Humans MH - *Autistic Disorder/epidemiology/therapy/complications MH - Child MH - Telemedicine MH - *Pediatric Obesity/therapy/epidemiology MH - *Behavior Therapy/methods MH - *Parents/education MH - Male MH - Female MH - Randomized Controlled Trials as Topic MH - Weight Loss MH - *Family Therapy/methods MH - Body Mass Index MH - Health Education/methods MH - Exercise OTO - NOTNLM OT - Autism OT - Child OT - Family-based behavioral treatment OT - Obesity OT - Parent OT - Parent-only OT - Telehealth OT - Weight loss COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/01 00:32 MHDA- 2026/06/15 11:33 CRDT- 2026/04/30 19:14 PHST- 2026/01/05 00:00 [received] PHST- 2026/04/22 00:00 [revised] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/06/15 11:33 [medline] PHST- 2026/05/01 00:32 [pubmed] PHST- 2026/04/30 19:14 [entrez] AID - S1551-7144(26)00116-3 [pii] AID - 10.1016/j.cct.2026.108330 [doi] PST - ppublish SO - Contemp Clin Trials. 2026 Jul;166:108330. doi: 10.1016/j.cct.2026.108330. Epub 2026 Apr 28. PMID- 42061520 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260819 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 408 DP - 2026 Sep 1 TI - Clinical utility of a quick and easy-to-use international tool for assessing and identifying impaired physical fitness in people with severe mental illness - The PsychiActive project. PG - 121898 LID - S0165-0327(26)00750-0 [pii] LID - 10.1016/j.jad.2026.121898 [doi] AB - BACKGROUND: Severe mental illness (SMI) is a leading cause of mortality, disability, and frailty, largely driven by physical multimorbidity. Physical fitness is a strong predictor of health outcomes, yet routine assessment is rarely implemented in SMI due to limited resources. Self-reported tools may offer a feasible alternative, although their validity and clinical utility remain unclear. This study evaluated the validity, reliability, and clinical utility of the International Fitness Scale (IFIS) in SMI. METHODS: In a multicenter cross-sectional study, 234 adults with SMI (18-65 years, 62 females) completed the IFIS and a battery of objective physical fitness tests. Convergent validity was assessed using ANOVA and ANCOVA. Test-retest reliability over two weeks was assessed using weighted kappa and percentage agreement. Clinical utility was evaluated using area under the curve, sensitivity, specificity, and positive predictive value. RESULTS: The IFIS effectively discriminated objective physical fitness across all domains and response categories in adults with severe mental illness (p < 0.005), with lower self-reported fitness consistently associated with poorer objective performance. Test-retest reliability was fair for the five-response scale (kappa = 0.22-0.32) and improved after category reduction (kappa = 0.26-0.50). The highest positive predictive value was observed for muscular strength (75%) and cardiorespiratory fitness (46%). The IFIS showed moderate discriminatory accuracy for cardiorespiratory fitness and flexibility (AUC = 0.64 for both domains). Mean completion time was 1.8 +/- 1.2 min. CONCLUSIONS: The IFIS is a valid, reliable, and time-efficient tool for identifying impaired physical fitness in adults with SMI. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Lopez-Moral, Alvaro AU - Lopez-Moral A AD - Physical Performance & Sports Research Center (CIRFD), Department of Sports and Computer Science, Section of Physical Education and Sports, Faculty of Sports Sciences, Universidad Pablo de Olavide, Sevilla, Spain; Department of Physical Education and Sport, Universidad de Sevilla, Sevilla, Spain. FAU - Munguia-Izquierdo, Diego AU - Munguia-Izquierdo D AD - Physical Performance & Sports Research Center (CIRFD), Department of Sports and Computer Science, Section of Physical Education and Sports, Faculty of Sports Sciences, Universidad Pablo de Olavide, Sevilla, Spain; Research Group in Development Movimiento Humano, Universidad de Zaragoza, Zaragoza, Spain. Electronic address: dmunizq@upo.es. FAU - Bueno-Antequera, Javier AU - Bueno-Antequera J AD - Physical Performance & Sports Research Center (CIRFD), Department of Sports and Computer Science, Section of Physical Education and Sports, Faculty of Sports Sciences, Universidad Pablo de Olavide, Sevilla, Spain; Research Group in Development Movimiento Humano, Universidad de Zaragoza, Zaragoza, Spain. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260429 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 SB - IM MH - Humans MH - Female MH - *Physical Fitness/physiology/psychology MH - Reproducibility of Results MH - Cross-Sectional Studies MH - Middle Aged MH - Adult MH - Male MH - *Mental Disorders/physiopathology MH - Adolescent MH - Aged MH - Young Adult MH - Sensitivity and Specificity MH - Self Report OTO - NOTNLM OT - Early detection OT - Fitness assessment OT - Functional impairment OT - Physical health screening OT - Psychiatric rehabilitation OT - Reliability OT - Validity COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/05/01 00:32 MHDA- 2026/05/13 00:29 CRDT- 2026/04/30 19:13 PHST- 2026/02/16 00:00 [received] PHST- 2026/04/26 00:00 [revised] PHST- 2026/04/27 00:00 [accepted] PHST- 2026/05/13 00:29 [medline] PHST- 2026/05/01 00:32 [pubmed] PHST- 2026/04/30 19:13 [entrez] AID - S0165-0327(26)00750-0 [pii] AID - 10.1016/j.jad.2026.121898 [doi] PST - ppublish SO - J Affect Disord. 2026 Sep 1;408:121898. doi: 10.1016/j.jad.2026.121898. Epub 2026 Apr 29. PMID- 42060500 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260914 IS - 0969-0700 (Print) IS - 0969-0700 (Linking) VI - 35 IP - 5 DP - 2026 May 2 TI - Incidence and risk factors of medical adhesive-related skin injury among ICU patients: a systematic review and meta-analysis. PG - 428-437 LID - 10.12968/jowc.2024.0404 [doi] AB - OBJECTIVE: To summarise the evidence regarding the incidence and risk factors of medical adhesive-related skin injury (MARSI) among patients in the intensive care unit (ICU). METHOD: A systematic review and meta-analysis was undertaken using articles available in nine databases: PubMed; the Cochrane Library; Web of Science; Embase; CINAHL; Chinese Biomedical Literature Database; China National Knowledge Infrastructure Database; Wanfang Database; and Weipu Database, from inception until 30 June 2024. Additional studies were identified by examining the references of relevant articles. The Stata 16.0 statistical platform (StataCorp LLC, US) was used for analysis. Study quality was assessed using the Newcastle-Ottawa Scale and the Agency for Healthcare Research and Quality standards. RESULTS: Of 14,743 titles screened, 19 studies involving 5218 patients were included in the systematic review. The pooled incidence of MARSI was 21% (95% confidence interval (CI): 14%, 28%), and the incidence of MARSI among neonatal ICU, paediatric ICU and adult ICU was 15% (95% CI: 6%, 26%), 48% (95% CI: 35%, 60%) and 16% (95% CI: 11%, 22%), respectively. Significant risk factors in adult ICUs included oedema (odds ratio (OR): 8.144; 95%CI: 3.267, 20.304), Braden scale score (OR: 0.733; 95%CI: 0.641, 0.837), length of ICU stay (OR: 1.072; 95%CI: 1.026, 1.120), mechanical ventilation (OR: 3.698; 95%CI: 1.900, 7.199), sedative use (OR: 6.022; 95%CI: 2.859, 12.687), Nutritional Risk Screening 2002 score (OR: 4.241; 95%CI: 1.984, 9.065) and hypoalbuminaemia (OR: 4.321; 95%CI: 1.967, 9.488). CONCLUSION: This study found that MARSI is prevalent among ICU patients and is associated with multiple risk factors. Improved strategies for identifying and clinically managing MARSI in ICU patients are needed. Nevertheless, large-sample and multicentre studies are still warranted to validate the present study's findings. FAU - Xu, Yaying AU - Xu Y AUID- ORCID: 0009-0006-4756-3830 AD - Zhongshan Hospital, Fudan University, Shanghai, China. FAU - Yan, Meiqiong AU - Yan M AD - Zhongshan Hospital, Fudan University, Shanghai, China. FAU - Pan, Wenyan AU - Pan W AD - Zhongshan Hospital, Fudan University, Shanghai, China. FAU - Li, Chunlei AU - Li C AD - Zhongshan Hospital, Fudan University, Shanghai, China. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260430 PL - England TA - J Wound Care JT - Journal of wound care JID - 9417080 RN - 0 (Adhesives) SB - IM MH - Humans MH - Risk Factors MH - *Intensive Care Units/statistics & numerical data MH - Incidence MH - *Skin/injuries MH - *Adhesives/adverse effects OTO - NOTNLM OT - incidence OT - intensive care units OT - medical adhesives OT - meta-analysis OT - skin injury OT - wound OT - wound care OT - wound dressing OT - wound healing COIS- Declaration of interest: The authors have no conflicts of interest. EDAT- 2026/04/30 18:32 MHDA- 2026/04/30 18:33 CRDT- 2026/04/30 13:02 PHST- 2026/04/30 18:33 [medline] PHST- 2026/04/30 18:32 [pubmed] PHST- 2026/04/30 13:02 [entrez] AID - 10.12968/jowc.2024.0404 [doi] PST - ppublish SO - J Wound Care. 2026 May 2;35(5):428-437. doi: 10.12968/jowc.2024.0404. Epub 2026 Apr 30. PMID- 42060313 OWN - NLM STAT- MEDLINE DCOM- 20260802 LR - 20260825 IS - 1521-0669 (Electronic) IS - 0888-0018 (Linking) VI - 43 IP - 5 DP - 2026 Aug TI - Feasibility and Validity of the 6-Minute Cycling Test in Childhood Cancer Patients. PG - 227-240 LID - 10.1080/08880018.2026.2661758 [doi] AB - The 6-min cycling test (6MCT), a submaximal endurance test, has not yet been applied in pediatric oncology. This study evaluates its feasibility and validity in 71 childhood cancer patients (9.6 +/- 4.0 years). For validation, 46 patients additionally underwent cardiopulmonary exercise testing (CPET). Performance in the 6MCT (total revolutions) was correlated with peak oxygen uptake (VO(2)(peak)) and peak work rate (WR(peak)) using Spearman's correlation. Linear regressions assessed the predictive value of VO(2)(peak) and WR(peak) on 6MCT performance. Sixty-six participants (93%) successfully completed the 6MCT, averaging 550 +/- 129 revolutions. Revolutions correlated moderately with VO(2)(peak) (rho = 0.46, p = 0.001) and strongly with WR(peak) (rho = 0.64, p < 0.001). VO(2)(peak) significantly predicted 6MCT performance (p = 0.001, R(2) = 0.214), whereas WR(peak) explained more variance (p < 0.001, R(2) = 0.488). The results demonstrate that the 6MCT is a feasible, valid endurance assessment in this population, offering a promising alternative when gold standard testing is not available. FAU - Wypyrsczyk, Lena AU - Wypyrsczyk L AD - Childhood Cancer Center Mainz, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. AD - Department of Sports Medicine, Disease Prevention and Rehabilitation, Johannes Gutenberg-University Mainz, Mainz, Germany. FAU - Kuhn, Mareike AU - Kuhn M AD - Childhood Cancer Center Mainz, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. AD - Department of Sports Medicine, Disease Prevention and Rehabilitation, Johannes Gutenberg-University Mainz, Mainz, Germany. FAU - Dreismickenbecker, Elias AU - Dreismickenbecker E AD - Childhood Cancer Center Mainz, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. AD - Department of Sports Medicine, Disease Prevention and Rehabilitation, Johannes Gutenberg-University Mainz, Mainz, Germany. FAU - Neu, Marie A AU - Neu MA AD - Childhood Cancer Center Mainz, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. FAU - Diel, Heidi AU - Diel H AD - Childhood Cancer Center Mainz, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. FAU - Faber, Joerg AU - Faber J AD - Childhood Cancer Center Mainz, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany. CN - FORTEe consortium LA - eng PT - Clinical Study PT - Journal Article PT - Validation Study DEP - 20260430 PL - England TA - Pediatr Hematol Oncol JT - Pediatric hematology and oncology JID - 8700164 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Exercise Test/methods MH - Feasibility Studies MH - *Neoplasms/physiopathology MH - *Oxygen Consumption MH - Physical Endurance MH - Child, Preschool OTO - NOTNLM OT - Cardiorespiratory fitness OT - childhood cancer OT - exercise oncology OT - exercise testing OT - validation study EDAT- 2026/04/30 12:35 MHDA- 2026/08/02 13:45 CRDT- 2026/04/30 11:44 PHST- 2026/08/02 13:45 [medline] PHST- 2026/04/30 12:35 [pubmed] PHST- 2026/04/30 11:44 [entrez] AID - 10.1080/08880018.2026.2661758 [doi] PST - ppublish SO - Pediatr Hematol Oncol. 2026 Aug;43(5):227-240. doi: 10.1080/08880018.2026.2661758. Epub 2026 Apr 30. PMID- 42059926 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261019 IS - 1432-198X (Electronic) IS - 0931-041X (Print) IS - 0931-041X (Linking) VI - 41 IP - 12 DP - 2026 Dec TI - Navigating the data-scarce landscape of pediatric hyperkalemia: a perspective on sodium zirconium cyclosilicate. PG - 4305-4310 LID - 10.1007/s00467-026-07333-3 [doi] AB - For decades, pediatric hyperkalemia has been managed largely with non-selective cation-exchange resins, despite limitations in tolerability, palatability, and gastrointestinal safety. This perspective reviews the role of sodium zirconium cyclosilicate (SZC) in children and places the pediatric evidence in the context of broader hyperkalemia management. Current pediatric SZC data remain sparse and are derived from a small retrospective cohort of children with chronic kidney disease (CKD) stages 4-5/5D and an in vitro infant formula pretreatment study. Within those constraints, SZC was associated with potassium reduction in acute and chronic settings, favorable tolerability, stable serum sodium and blood pressure, and high acceptability, which is relevant in pediatrics, where palatability and adherence often determine effectiveness. The available literature also suggests practical pediatric applications, including age-based oral dosing and formula-pretreatment strategies, although no validated weight-based regimen has been established. Beyond potassium lowering, SZC may support a more individualized approach to potassium management in selected children, potentially reducing the need for broad dietary restriction and helping preserve renin-angiotensin-aldosterone system inhibitor therapy when hyperkalemia becomes a limiting factor. However, these broader clinical implications remain preliminary, largely observational, and partly extrapolated from adult data. Accordingly, SZC should not yet be viewed as an established pediatric practice standard, but rather as a promising adjunct for carefully selected patients in whom older resins are poorly tolerated or ongoing hyperkalemia compromises diet quality or cardiorenal therapy. Until prospective pediatric trials better define dosing, safety, and patient-centered outcomes, any off-label use should remain individualized and closely monitored. CI - (c) 2026. The Author(s). FAU - Correa, Lucas Maciel de Almeida AU - Correa LMA AUID- ORCID: 0009-0003-7247-4950 AD - Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), Avenida Brigadeiro Faria Lima, 5544, 15090-000, Sao Jose do Rio Preto, SP, Brazil. lucasmacielll@icloud.com. FAU - Santiago, Clara Belo Gamon AU - Santiago CBG AD - Universidade Estadual de Mato Grosso do Sul (UEMS), Campo Grande, Brazil. FAU - Barbosa, Alexandre de Assis AU - Barbosa AA AD - Universidade Estadual de Mato Grosso do Sul (UEMS), Campo Grande, Brazil. FAU - Brandao, Luiggi Kevin Virgino AU - Brandao LKV AD - Centro Universitario Uninorte (UNINORTE), Rio Branco, Brazil. FAU - Fernandes, Camilla Cristina Silva AU - Fernandes CCS AD - Universidade do Estado da Bahia (UNEB), Salvador, Brazil. FAU - Milan, Leticia Mantovani AU - Milan LM AD - Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), Avenida Brigadeiro Faria Lima, 5544, 15090-000, Sao Jose do Rio Preto, SP, Brazil. FAU - Carneiro, Paula Ramos AU - Carneiro PR AD - Faculdade de Medicina de Sao Jose do Rio Preto (FAMERP), Avenida Brigadeiro Faria Lima, 5544, 15090-000, Sao Jose do Rio Preto, SP, Brazil. LA - eng PT - Journal Article PT - Review DEP - 20260430 PL - Germany TA - Pediatr Nephrol JT - Pediatric nephrology (Berlin, Germany) JID - 8708728 RN - D652ZWF066 (sodium zirconium cyclosilicate) RN - 0 (Silicates) RN - RWP5GA015D (Potassium) RN - 0 (Cation Exchange Resins) SB - IM MH - Humans MH - *Hyperkalemia/drug therapy/etiology/blood MH - *Silicates/therapeutic use/administration & dosage/adverse effects MH - Child MH - Potassium/blood MH - *Renal Insufficiency, Chronic/complications/blood MH - Renin-Angiotensin System/drug effects MH - *Cation Exchange Resins/therapeutic use MH - Infant MH - Treatment Outcome PMC - PMC13672472 OTO - NOTNLM OT - Chronic kidney disease OT - Hyperkalemia OT - Pediatrics OT - Renin-angiotensin system inhibitors OT - Sodium zirconium cyclosilicate COIS- Declarations. Ethics approval: Not applicable (review article). Consent to participate: Not applicable. Consent for publication: Not applicable. Conflict of interest: The authors declare no competing interests. EDAT- 2026/04/30 12:34 MHDA- 2026/10/15 23:30 PMCR- 2026/04/30 CRDT- 2026/04/30 11:03 PHST- 2026/02/07 00:00 [received] PHST- 2026/04/23 00:00 [accepted] PHST- 2026/04/12 00:00 [revised] PHST- 2026/10/15 23:30 [medline] PHST- 2026/04/30 12:34 [pubmed] PHST- 2026/04/30 11:03 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - 10.1007/s00467-026-07333-3 [pii] AID - 7333 [pii] AID - 10.1007/s00467-026-07333-3 [doi] PST - ppublish SO - Pediatr Nephrol. 2026 Dec;41(12):4305-4310. doi: 10.1007/s00467-026-07333-3. Epub 2026 Apr 30. PMID- 42058714 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260430 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Association of logarithmic lymphocyte-albumin product with active tuberculosis in children and adolescents. PG - 1781667 LID - 10.3389/fnut.2026.1781667 [doi] LID - 1781667 AB - BACKGROUND: Active tuberculosis (ATB) in children and adolescents remains a major diagnostic challenge. Inflammation, nutrition, and immune status are closely linked to tuberculosis (TB) progression. We therefore proposed a novel biomarker, the logarithmic lymphocyte-albumin product (logLAP), integrating immune and nutritional indicators, and investigated its association with ATB in children and adolescents. METHODS: This retrospective study included 1,080 participants aged <18 years. Participants were classified into ATB (n = 904) and non-TB (n = 176) groups. LAP was calculated as lymphocyte x albumin, and logLAP was derived as log(LAP). Discriminatory ability was evaluated using receiver operating characteristic (ROC) curves. Logistic regression models were applied to assess the association between logLAP and ATB. Restricted cubic spline (RCS) analyses and stratified analyses were conducted to explore nonlinear relationships and subgroup differences. RESULTS: Compared with non-TB controls, ATB patients exhibited significantly lower logLAP levels (4.07 +/- 0.55 vs. 4.39 +/- 0.47, p < 0.001). In ROC analysis, LAP achieved the higher area under the curve (AUC = 0.6955) than neutrophil-lymphocyte ratio (NLR), neutrophil-albumin ratio (NAR), platelet-lymphocyte ratio (PLR), systemic immune-inflammation index (SII) and prognostic-nutritional index (PNI). The clinical diagnostic cut-off value for logLAP was 4.23, with a sensitivity of 60% and a specificity of 74%. Logistic regression models revealed the third tertile (Q3) of logLAP showed a strong inverse association with ATB (OR = 0.33, 95% CI: 0.18-0.59, p < 0.001) after full adjustment. RCS analyses with four knots revealed a significant non-linear relationship between logLAP and ATB (p for non-linearity = 0.021), confirming a threshold effect at logLAP = 3.48. Stratified analyses indicated consistent associations across most subgroups, while logLAP showed limited associations in children aged 0-7 years and those with severe immune dysfunction (CD4+/CD8+ T cell counts below the reference range). The AUC of logLAP demonstrated a clear advantage over traditional biomarkers; however, its diagnostic performance remained relatively limited. This suggests that logLAP is more suitable as a supplementary tool and should be used in conjunction with other clinical or laboratory indicators. CONCLUSION: As a biomarker integrating immune-nutritional status, logLAP exhibits a robust inverse association with ATB infection in children and adolescents aged >/=8 years with normal or moderately impaired immune function, supported by comprehensive analyses. CI - Copyright (c) 2026 Chen, Deng, Wang, Tang, Wang, Chen and An. FAU - Chen, Jinyu AU - Chen J AD - Department of Tuberculosis, Public Health Clinical Center of Chengdu, Chengdu, Sichuan, China. FAU - Deng, Bin AU - Deng B AD - Department of Tuberculosis, Public Health Clinical Center of Chengdu, Chengdu, Sichuan, China. FAU - Wang, Yan AU - Wang Y AD - Department of Tuberculosis, Public Health Clinical Center of Chengdu, Chengdu, Sichuan, China. FAU - Tang, Shenjie AU - Tang S AD - Beijing Chest Hospital, Capital Medical University, Beijing, China. FAU - Wang, Dongmei AU - Wang D AD - Department of Tuberculosis, Public Health Clinical Center of Chengdu, Chengdu, Sichuan, China. FAU - Chen, Lei AU - Chen L AD - Department of Tuberculosis, Public Health Clinical Center of Chengdu, Chengdu, Sichuan, China. FAU - An, Qi AU - An Q AD - Department of Tuberculosis, Public Health Clinical Center of Chengdu, Chengdu, Sichuan, China. LA - eng PT - Journal Article DEP - 20260414 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13123255 OTO - NOTNLM OT - active tuberculosis OT - albumin OT - biomarker OT - children and adolescents OT - immune-nutritional biomarker OT - lymphocyte COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/30 06:33 MHDA- 2026/04/30 06:34 PMCR- 2026/04/14 CRDT- 2026/04/30 04:54 PHST- 2026/01/06 00:00 [received] PHST- 2026/03/06 00:00 [revised] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/04/30 06:34 [medline] PHST- 2026/04/30 06:33 [pubmed] PHST- 2026/04/30 04:54 [entrez] PHST- 2026/04/14 00:00 [pmc-release] AID - 10.3389/fnut.2026.1781667 [doi] PST - epublish SO - Front Nutr. 2026 Apr 14;13:1781667. doi: 10.3389/fnut.2026.1781667. eCollection 2026. PMID- 42057279 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260921 IS - 2162-3279 (Electronic) VI - 16 IP - 5 DP - 2026 May TI - Ecological Factors Associated With Psychological Distress Among Adolescents: The Role of Educational Stress, Peer Victimization, and Physical Activity. PG - e71450 LID - 10.1002/brb3.71450 [doi] LID - e71450 AB - BACKGROUND: Adolescent psychological distress is shaped by influences across educational, familial, peer, and behavioral domains, yet few studies in low- and middle-income countries (LMICs) have examined these determinants within a unified theoretical framework. Guided by Bronfenbrenner's bioecological model, this study investigated ecological factors associated with psychological distress among Bangladeshi adolescents, with particular attention to educational stress, peer victimization, and physical activity. METHODS: A school-based cross-sectional survey was conducted among 501 higher secondary students in Bangladesh. Psychological distress was assessed using the Depression Anxiety and Stress Scale-21, whereas educational stress, family relationship quality, peer relationships, and physical activity were measured using validated instruments. Hierarchical multiple linear regression models evaluated the incremental contribution of theoretically ordered factor blocks. Relative importance analysis (Lindeman-Merenda-Gold method) quantified each factor's proportional contribution to explained variance. Domain-specific regression models were conducted for depression, anxiety, and stress. Heteroskedasticity-consistent (HC3) robust standard errors were applied. RESULTS: The fully adjusted model explained 23.8% of the variance in overall psychological distress. Educational stress (B = 0.56, p < 0.001), female gender (B = 12.32, p < 0.001), and peer victimization (B = 2.07, p < 0.001) were positively associated with distress, whereas physical activity was inversely associated (B = -0.91, p = 0.004). Relative importance analysis indicated that educational stress (20.4%), gender (17.7%), peer victimization (16.8%), and physical activity (15.9%) accounted for the largest proportions of explained variance. Similar patterns were observed across depression, anxiety, and stress subscales. CONCLUSIONS: Psychological distress among Bangladeshi adolescents is associated with the combined influence of academic pressure, peer victimization, gender-related vulnerability, and behavioral health factors. Interventions that address educational stress and peer safety while promoting physical activity may help inform a coordinated and contextually grounded strategy for adolescent mental health prevention in Bangladesh and similar LMIC settings. CI - (c) 2026 The Author(s). Brain and Behavior published by Wiley Periodicals LLC. FAU - Al-Mamun, Firoj AU - Al-Mamun F AUID- ORCID: 0000-0003-4611-9624 AD - CHINTA Research Bangladesh, Dhaka, Bangladesh. AD - Department of Public Health, University of South Asia, Dhaka, Bangladesh. FAU - Nodi, Tasmin Sayeed AU - Nodi TS AUID- ORCID: 0009-0002-3561-4224 AD - CHINTA Research Bangladesh, Dhaka, Bangladesh. FAU - Abdullah, Abu Hasnat AU - Abdullah AH AUID- ORCID: 0000-0001-7375-6085 AD - CHINTA Research Bangladesh, Dhaka, Bangladesh. AD - Department of Public Health, Daffodil International University, Dhaka, Bangladesh. FAU - Hossain, Susmita AU - Hossain S AD - CHINTA Research Bangladesh, Dhaka, Bangladesh. AD - Bangladesh Dental College, Dhaka, Bangladesh. FAU - Hasan, Md Mehedee AU - Hasan MM AUID- ORCID: 0009-0005-3683-3762 AD - CHINTA Research Bangladesh, Dhaka, Bangladesh. FAU - Malakar, Jyotie AU - Malakar J AUID- ORCID: 0009-0007-3171-0039 AD - CHINTA Research Bangladesh, Dhaka, Bangladesh. AD - Department of Maternal and Child Health, National Institute of Preventive and Social Medicine, Dhaka, Bangladesh. FAU - Abdelall, Maysa Mohamed Rabea AU - Abdelall MMR AD - Department of Physical Sport Sciences, College of Sport Sciences and Physical Activity Princess Nourah bint Abdulrahman University, Riyadh. FAU - Mamun, Mohammed A AU - Mamun MA AUID- ORCID: 0000-0002-1728-8966 AD - CHINTA Research Bangladesh, Dhaka, Bangladesh. AD - Department of Public Health, University of South Asia, Dhaka, Bangladesh. LA - eng GR - PNURSP2026R802/Princess Nourah Bint Abdulrahman University Researchers Supporting/ PT - Journal Article PL - United States TA - Brain Behav JT - Brain and behavior JID - 101570837 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Peer Group MH - Male MH - *Crime Victims/psychology MH - Bangladesh MH - Cross-Sectional Studies MH - *Stress, Psychological/psychology MH - *Exercise/psychology MH - *Psychological Distress MH - Students/psychology MH - Anxiety/psychology MH - Depression/psychology MH - *Bullying/psychology PMC - PMC13128966 OTO - NOTNLM OT - adolescent mental health OT - ecological model OT - educational stress OT - peer victimization OT - physical activity OT - psychological distress COIS- The authors declare no conflicts of interest. EDAT- 2026/04/30 06:34 MHDA- 2026/04/30 06:35 PMCR- 2026/04/29 CRDT- 2026/04/30 00:34 PHST- 2026/03/21 00:00 [revised] PHST- 2026/02/23 00:00 [received] PHST- 2026/04/14 00:00 [accepted] PHST- 2026/04/30 06:35 [medline] PHST- 2026/04/30 06:34 [pubmed] PHST- 2026/04/30 00:34 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - BRB371450 [pii] AID - 10.1002/brb3.71450 [doi] PST - ppublish SO - Brain Behav. 2026 May;16(5):e71450. doi: 10.1002/brb3.71450. PMID- 42057239 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260627 LR - 20260813 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 12 IP - 1 DP - 2026 Apr 29 TI - Unraveling the Diet-Learning Nexus: a cross-sectional deep dive into Iranian adolescents' nutrient patterns and learning difficulties. LID - 10.1186/s40795-026-01338-9 [doi] LID - 115 AB - BACKGROUND: learning difficulties (LDs), which encompass deficits in academic achievement and cognitive processing, are associated with significant functional challenges. Research indicates that dietary patterns and nutrient intake represent environmental factors that may exert influence on the phenotypic expression or trajectory of such neurodevelopmental disorders. This study examined the association between nutrient patterns and LDs in school-aged adolescents in Iran. METHODS: A cross-sectional descriptive-analytical study was conducted from March to June 2024 in four secondary schools (two all-female and two all-male) in Jahrom, Iran. A total of 455 male and female adolescents aged 14 to 18 years participated. Adolescents with pre-existing medical conditions (cardiovascular disease, diabetes mellitus, hepatic or renal disease), those following specific dietary regimens, or with incomplete data were excluded. LDs were assessed using the Colorado Learning Difficulties Questionnaire (CLDQ). Dietary intake was assessed via a validated 168-item Food Frequency Questionnaire (FFQ). Seven nutrient patterns (NP) were identified through factor analysis. Anthropometric measurements and socioeconomic variables were also collected. Higher scores of CLDS reflect greater LDs. RESULTS: Adolescents were classified into tertiles based on CLDS. The first tertile of NPs and CLDS was considered as a reference. Moderate adherence to NP4, characterized by higher glutamine and lower glucose, fructose, vitamins C, A, and E, and potassium, was associated with increased odds of being in the highest CLDS tertile in the fully adjusted model (OR 2.50; 95% CI 1.32-4.71). High adherence to NP7, characterized by lower intake of sodium, MUFA, and vitamin D, was associated with lower odds of being in the highest CLDS tertile in the full adjusted model (OR 0.48; 95% CI 0.25-0.91). CONCLUSION: Adherence to a low antioxidant and glucose-content NP diet characterized by higher glutamine and lower intakes of glucose, fructose, vitamins C, A, and E, and potassium was positively associated with LDs in Iranian adolescents. Additionally, high adherence to a low-sodium diet was associated with lower odds of being in the highest CLDS tertile. FAU - Rahmanian, Reza AU - Rahmanian R AUID- ORCID: 0009-0004-0125-5096 AD - Student research committee, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. AD - Department of Clinical Nutrition, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Razeghi-Pirbasti, Ali AU - Razeghi-Pirbasti A AUID- ORCID: 0009-0003-7237-5784 AD - Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Shaygantabar, Mohsen AU - Shaygantabar M AUID- ORCID: 0009-0006-5483-9495 AD - Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Bahreini-Boroujeni, Leyli Zahra AU - Bahreini-Boroujeni LZ AUID- ORCID: 0009-0006-3898-051X AD - Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Jowshan, Mohammad-Reza AU - Jowshan MR AUID- ORCID: 0000-0001-8603-5674 AD - Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran. mr.jowshan@gmail.com. AD - Student Research Committee, Iran University of Medical Sciences, Tehran, Iran. mr.jowshan@gmail.com. AD - School of Paramedical, Gerash University of Medical Sciences, Gerash, Iran. mr.jowshan@gmail.com. LA - eng PT - Journal Article DEP - 20260429 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC13274175 OTO - NOTNLM OT - Cognitive Function OT - Dietary pattern OT - Learning Difficulties OT - Nutrition COIS- Declarations. Ethics approval and consent to participate: The research was approved by the Ethics Committee of the National Nutrition and Food Technology Research Institute at Shahid Beheshti University of Medical Sciences, Iran (IR.SBMU.NNFTRI.REC.1403.016). The study adheres to the principles outlined in the Declaration of Helsinki. Written informed consent was obtained from all participants. For participants under 16 years of age, informed consent was also obtained from their parents or legal guardians before enrollment. All personal information about participants will be kept secure in a database. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/30 06:34 MHDA- 2026/04/30 06:35 PMCR- 2026/04/29 CRDT- 2026/04/30 00:33 PHST- 2026/01/21 00:00 [received] PHST- 2026/04/23 00:00 [accepted] PHST- 2026/04/30 06:35 [medline] PHST- 2026/04/30 06:34 [pubmed] PHST- 2026/04/30 00:33 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - 10.1186/s40795-026-01338-9 [pii] AID - 1338 [pii] AID - 10.1186/s40795-026-01338-9 [doi] PST - epublish SO - BMC Nutr. 2026 Apr 29;12(1):115. doi: 10.1186/s40795-026-01338-9. PMID- 42056320 OWN - NLM STAT- MEDLINE DCOM- 20260616 LR - 20260813 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Apr 29 TI - Psychobehavioral profiles of eating risk: schema-emotion regulation patterns differ in central adiposity with genotype (FTO rs9939609) as external validator-a pilot study. LID - 10.1007/s40519-026-01853-5 [doi] LID - 57 AB - PURPOSE: To identify person-centered psychological profiles of eating-related risk based on early maladaptive schemas (EMS), emotion regulation difficulties, and eating behaviors, and to examine their external validation using anthropometric indices (BMI, waist circumference, WC) and the FTO rs9939609 genotype. METHODS: Fifty women aged 18-35 years (approximately balanced between normal weight and overweight/obese groups) completed the YSQ-S3, DERS-36, and QERB. Standardized variables were clustered with k-means (k = 2-4); the optimal solution was selected via silhouette and BIC with stability checks. BMI and WC were used for external validation; FTO rs9939609 (AA/AT/TT) was examined using chi(2)/Fisher's tests. RESULTS: A two-cluster solution best fit the data. Cluster 1 (n = 23) showed higher EMS, greater emotion dysregulation, and higher emotional/habitual overeating, alongside higher restraint, whereas Cluster 2 (n = 27) showed a consistently lower-risk profile. Cluster 1 presented higher WC (M = 92.74 cm, SD = 12.86) and BMI (M = 30.44, SD = 5.18) than Cluster 2 (WC: M = 75.19 cm, SD = 18.60; BMI: M = 22.65, SD = 4.15); differences were significant in parametric and nonparametric tests (all p < 0.001; Hedges' g = 1.07-1.65). The FTO genotype distribution did not differ between clusters (chi(2)(2) = 0.33, p = 0.848). CONCLUSIONS: Distinct schema-emotion regulation profiles may be observable in young women and appear to align with central adiposity and BMI. While FTO rs9939609 did not differentiate clusters, person-centered profiling may help inform hypothesis generation regarding schema- and regulation-focused strategies in weight-related risk, with potential relevance for both clinical and educational contexts. LEVEL OF EVIDENCE: Level III, observational analytic (cross-sectional) study. CI - (c) 2026. The Author(s). FAU - Obara-Golebiowska, Malgorzata AU - Obara-Golebiowska M AUID- ORCID: 0000-0003-0057-4365 AD - Department of Clinical, Developmental and Educational Psychology, Faculty of Social Sciences, University of Warmia and Mazury in Olsztyn, Ul. Dybowskiego 13, 10-723, Olsztyn, Poland. m.obara-golebiowska@uwm.edu.pl. LA - eng GR - (Miniatura; DEC-2019/03/X/HS6/00204)./National Science Center, Poland/ PT - Journal Article DEP - 20260429 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 RN - EC 1.14.11.33 (Alpha-Ketoglutarate-Dependent Dioxygenase FTO) RN - EC 1.14.11.33 (FTO protein, human) SB - IM MH - Humans MH - Female MH - *Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics MH - Pilot Projects MH - Young Adult MH - Adult MH - Genotype MH - Adolescent MH - *Emotional Regulation/physiology MH - *Feeding Behavior/psychology/physiology MH - Body Mass Index MH - Adiposity/genetics MH - Waist Circumference MH - *Obesity, Abdominal/genetics/psychology PMC - PMC13269516 OTO - NOTNLM OT - Central adiposity OT - Cluster analysis OT - Early maladaptive schemas OT - Eating behavior OT - Emotion regulation OT - Health education COIS- Declarations. Ethics approval and consent to participate: Approved by the Ethics Committee for Scientific Research at the University of Warmia and Mazury in Olsztyn, Poland (Decision No. 3/2019); the procedures adhered to the Declaration of Helsinki. Written informed consent was obtained from all participants. Consent for publication: Not applicable. Competing interest: The authors declare no competing interest. EDAT- 2026/04/30 00:31 MHDA- 2026/06/16 06:35 PMCR- 2026/04/29 CRDT- 2026/04/29 23:25 PHST- 2025/10/13 00:00 [received] PHST- 2026/04/07 00:00 [accepted] PHST- 2026/06/16 06:35 [medline] PHST- 2026/04/30 00:31 [pubmed] PHST- 2026/04/29 23:25 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - 10.1007/s40519-026-01853-5 [pii] AID - 1853 [pii] AID - 10.1007/s40519-026-01853-5 [doi] PST - epublish SO - Eat Weight Disord. 2026 Apr 29;31(1):57. doi: 10.1007/s40519-026-01853-5. PMID- 42055614 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 4 DP - 2026 Apr 29 TI - Prevent 6:1 trial: pI rotocol for a feasibility trial of a 6:1 intermittent diet for weight gain prevention in women at increased risk of breast cancer. PG - e113204 LID - 10.1136/bmjopen-2025-113204 [doi] LID - e113204 AB - INTRODUCTION: Weight gain in adulthood is a common potentially modifiable breast cancer risk factor. Intermittent 5:2 diets (two low-calorie days/week) have proven efficacy for weight loss among people with overweight or obesity and can promote sustained awareness and mindfulness of diet choice and help appetite control.This trial aims to test whether a less intensive 6:1 intermittent diet programme (one low-calorie day/week) is a feasible intervention to promote healthy eating and prevent weight gain in women at increased risk of breast cancer. METHODS AND ANALYSIS: Single arm prospective feasibility trial in 30 healthy weight women aged 18-40 years, at moderate or high risk of breast cancer (>/=17% lifetime risk and/or >/=3% 10 year risk at 40 years), body mass index 20-25 kg/m(2). Participants will be entered to a 16-week 6:1 diet programme involving 1 day consuming 1000 kcal and healthy eating for 6 days a week. Participants will also be advised to meet physical activity recommendations for health (>/=150 min of moderate intensity physical activity/week and resistance exercise two times per week). The programme will be supported remotely by dietitian calls at baseline, week 1, 4, 8, 12 and 16. Participants will also be provided access to a trial-specific private monitored Facebook group which includes information and the opportunity for peer support.Co-primary outcomes are: (a) uptake to the trial, (b) retention rate, (c) adherence to the 6:1 diet and (d) participant feedback on acceptability of the programme. Secondary outcomes include characteristics of those recruited and completing the programme and a preliminary evaluation of benefits and harms. This includes changes in body weight and body composition (bioelectrical impedance), diet quality, physical activity, binge eating, sleep quality (Pittsburgh Sleep Quality Index), menstrual cycle length and potentially diet-related adverse events, that is, fatigue, constipation, dizziness, headache, indigestion. Exploratory outcomes include the impact of low-calorie days on dietary intake and physical activity across the week and any differences in adherence to the low calorie days across the menstrual cycle. ETHICS AND DISSEMINATION: This trial has been approved by South Central-Berkshire B Research Ethics committee (rec reference 24/SC/0321). Findings will be disseminated via peer-reviewed journals, national and international cancer prevention and obesity conferences and cancer prevention charitable bodies. TRIAL REGISTRATION NUMBER: ISRCTN14330469. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Kinsey, Laura AU - Kinsey L AD - Manchester Adult Cystic Fibrosis Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK. AD - The Prevent Breast Cancer Research Unit, Manchester University NHS Foundation Trust, Manchester, UK. FAU - French, David AU - French D AUID- ORCID: 0000-0002-7663-7804 AD - Division of Psychology and Mental Health, School of Health Sciences, The University of Manchester Faculty of Biology Medicine and Health, Manchester, UK. FAU - Howell, Sacha AU - Howell S AD - The Prevent Breast Cancer Research Unit, Manchester University NHS Foundation Trust, Manchester, UK. AD - Division of Cancer Sciences, The University of Manchester, Manchester, UK. FAU - Gill, Jason AU - Gill J AUID- ORCID: 0000-0003-3615-0986 AD - BHF Glasgow Cardiovascular Research Centre, School of Cardiovascular & Metabolic Health, University of Glasgow, Glasgow, UK. FAU - Lombardelli, Cheryl AU - Lombardelli C AUID- ORCID: 0009-0009-8919-9493 AD - The Prevent Breast Cancer Research Unit, Manchester University NHS Foundation Trust, Manchester, UK. FAU - Haiba, Mai AU - Haiba M AD - The Prevent Breast Cancer Research Unit, Manchester University NHS Foundation Trust, Manchester, UK. AD - Manchester Academic Health Science Centre, Manchester, UK. FAU - Barrett, Emma AU - Barrett E AUID- ORCID: 0000-0002-3882-7199 AD - Department of Medical Statistics, Manchester University NHS Foundation Trust, Manchester, UK. FAU - Jones, Natasha AU - Jones N AD - Research and Innovation, Manchester University NHS Foundation Trust, Manchester, UK. FAU - Wisely, Julie AU - Wisely J AUID- ORCID: 0000-0002-1698-5014 AD - Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK. FAU - Harvie, Michelle AU - Harvie M AUID- ORCID: 0000-0001-9761-3089 AD - The Prevent Breast Cancer Research Unit, Manchester University NHS Foundation Trust, Manchester, UK Michelle.Harvie@manchester.ac.uk. AD - Division of Cancer Sciences, The University of Manchester, Manchester, UK. AD - Manchester Academic Health Science Centre, Manchester, UK. LA - eng PT - Journal Article DEP - 20260429 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Female MH - Feasibility Studies MH - *Breast Neoplasms/prevention & control MH - Adult MH - *Weight Gain MH - Young Adult MH - Adolescent MH - Prospective Studies MH - *Obesity/diet therapy MH - Body Mass Index MH - Exercise MH - Risk Factors MH - Overweight MH - *Diet, Healthy PMC - PMC13140951 OTO - NOTNLM OT - Breast tumours OT - Fasting OT - NUTRITION & DIETETICS OT - Overweight OT - Primary Prevention OT - Weight Gain COIS- Competing interests: MHar has coauthored three self-help books for the public to follow intermittent diets. All author proceeds are paid directly to the charity Prevent Breast Cancer (registered charity number 1109839) to fund breast cancer research. EDAT- 2026/04/30 00:30 MHDA- 2026/04/30 00:31 PMCR- 2026/04/29 CRDT- 2026/04/29 20:53 PHST- 2026/04/30 00:31 [medline] PHST- 2026/04/30 00:30 [pubmed] PHST- 2026/04/29 20:53 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - bmjopen-2025-113204 [pii] AID - 10.1136/bmjopen-2025-113204 [doi] PST - epublish SO - BMJ Open. 2026 Apr 29;16(4):e113204. doi: 10.1136/bmjopen-2025-113204. PMID- 42055464 OWN - NLM STAT- MEDLINE DCOM- 20260607 LR - 20260630 IS - 2254-8874 (Electronic) IS - 2254-8874 (Linking) VI - 226 IP - 6 DP - 2026 Jun-Jul TI - Executive summary of the consensus document on management of the transition of patients with inborn errors of intermediary metabolism. PG - 502548 LID - S2254-8874(26)00087-1 [pii] LID - 10.1016/j.rceng.2026.502548 [doi] AB - Inborn errors of intermediary metabolism (IEiM) are rare genetic diseases with significant morbidity and mortality, requiring complex and continuous management throughout life. To ensure continuity of care and improve patient outcomes and quality of life, a transition from pediatric to adult care must be made. However, this transition is not standardised, and its current status in Spain is unknown. In this study, 11 experts in IEiM (Endocrinology and Nutrition, Pediatrics, Internal Medicine, pediatric Neurology) developed questions and statements to validate in a survey based on the Delphi method, where 25 experts participated. Data from current clinical practice in Spain were obtained regarding patients with IEiM and their transition, with 68% of participants reporting that up to 25% of patients who should be managed as adults receive care in Pediatrics. Subsequently, we proposed 24 recommendations to improve the transition of patients with IEiM. CI - Copyright (c) 2026 The Authors. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Martinez Olmos, M A AU - Martinez Olmos MA AD - Servicio de Endocrinologia y Nutricion, Complejo Hospitalario Universitario de Santiago de Compostela, Santiago de Compostela, Spain; Instituto de Investigacion Sanitaria de Santiago de Compostela, CIBEROBN, Santiago de Compostela, Spain. Electronic address: miguel.angel.martinez.olmos@sergas.es. FAU - Alcalde-Martin, C AU - Alcalde-Martin C AD - Servicio de Pediatria, Hospital Universitario Rio Hortega, Valladolid, Spain. FAU - Belanger-Quintana, A AU - Belanger-Quintana A AD - Unidad de Enfermedades Metabolicas Pediatricas, Hospital Universitario Ramon y Cajal, Madrid, Spain. FAU - Burgos Pelaez, R AU - Burgos Pelaez R AD - Unidad de Soporte Nutricional, Servicio de Endocrinologia y Nutricion, Hospital Universitario Vall d'Hebron, Barcelona, Spain. FAU - de Las Heras, J AU - de Las Heras J AD - Unidad de Trastornos Congenitos del Metabolismo, Hospital Universitario de Cruces, Universidad del Pais Vasco e Instituto de Investigacion Sanitaria Biobizkaia, Barakaldo, Spain. FAU - Del Toro, M AU - Del Toro M AD - Servicio de Neurologia Pediatrica, Hospital Universitario Vall d'Hebron, Barcelona, Spain. FAU - Forga Visa, M AU - Forga Visa M AD - Servicio de Medicina Interna, Hospital Clinic de Barcelona, Barcelona, Spain. FAU - Morais-Lopez, A AU - Morais-Lopez A AD - Unidad de Nutricion Infantil y Enfermedades Metabolicas, Hospital Universitario La Paz, Madrid, Spain. FAU - Morales-Conejo, M AU - Morales-Conejo M AD - Consulta de Enfermedades Minoritarias, CSUR de Errores Congenitos del Metabolismo, Servicio de Medicina Interna, Hospital Universitario 12 de Octubre, Madrid, Spain. FAU - Venegas-Moreno, E AU - Venegas-Moreno E AD - Unidad de Gestion de Endocrinologia y Nutricion, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocio/CSIC/Universidad de Sevilla, Sevilla, Spain. FAU - Vitoria Minana, I AU - Vitoria Minana I AD - Unidad de Nutricion y Metabolopatias, Hospital Universitario La Fe, Valencia, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260427 PL - Spain TA - Rev Clin Esp (Barc) JT - Revista clinica espanola JID - 101632437 SB - IM MH - Adult MH - Humans MH - Delphi Technique MH - *Metabolism, Inborn Errors/therapy MH - Spain MH - *Transition to Adult Care/standards MH - Consensus Statements as Topic OTO - NOTNLM OT - Errores innatos del metabolismo OT - Espana OT - Inborn errors of metabolism OT - Pediatrics OT - Pediatria OT - Spain OT - Transicion a la atencion de adultos OT - Transition to adult care COIS- Declaration of competing interest Carlos Alcalde Martin has attended training activities and/or congresses funded by Nutricia and Vitaflo. Amaya Belanger Quintana has received fees for preparing presentations, organizing courses, research, and/or travel expenses from Biomarin, Danone, Grand Fontaine, Immedica, Nutricia, Rendon, Recordati Rare Diseases, PTC Therapeutics, Sanofi, and Takeda. Eva Venegas has received fees for lectures from Nutricia, Vitaflo, and Mead Johnson. Isidro Vitoria Minana has received fees for lectures, course organization, and scientific projects from Biomarin, Immedica, Nutricia, Recordati, Mead-Johnson, Vitaflo, Sanofi, and Lucane. Miguel Angel Martinez Olmos, Rosa Burgos, Javier de las Heras, Mireia del Toro, Maria Forga, Ana Morais Lopez, and Montse Morales-Conejo declare no conflicts of interest. EDAT- 2026/04/30 00:31 MHDA- 2026/06/07 13:43 CRDT- 2026/04/29 19:17 PHST- 2025/11/19 00:00 [received] PHST- 2026/03/29 00:00 [accepted] PHST- 2026/06/07 13:43 [medline] PHST- 2026/04/30 00:31 [pubmed] PHST- 2026/04/29 19:17 [entrez] AID - S2254-8874(26)00087-1 [pii] AID - 10.1016/j.rceng.2026.502548 [doi] PST - ppublish SO - Rev Clin Esp (Barc). 2026 Jun-Jul;226(6):502548. doi: 10.1016/j.rceng.2026.502548. Epub 2026 Apr 27. PMID- 42054802 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260612 IS - 1878-1799 (Electronic) IS - 1871-5192 (Linking) VI - 39 IP - 3 DP - 2026 Jun TI - A pilot feasibility study of a continuity of care model of breastfeeding support in a regional Australian population. PG - 102207 LID - S1871-5192(26)00048-X [pii] LID - 10.1016/j.wombi.2026.102207 [doi] AB - PROBLEM: Despite numerous public health initiatives, rates of exclusive breastfeeding in Australia do not meet recommendations. BACKGROUND: Currently 35% of maternity services provide some form of continuity of care, with superior results in key outcomes. AIM: This pilot study was undertaken to determine feasibility of a lactation consultant led continuity of care model for breastfeeding support. METHODS: Randomisation occurred at 36-weeks gestation. Usual care followed NSW Health guidelines, the new model provided support by a board-certified lactation consultant, with up to 14 postnatal appointments available until six months postpartum. The primary outcome was study feasibility, measured by recruitment and retention, and protocol adherence. Secondary outcomes were breastfeeding rates at discharge, 4-months and 6-months postpartum. FINDINGS: Recruitment uptake was high, over 95% of women approached enrolled in the study, with 90.1% completing the study protocol. Attrition was < 10% and rates of monthly data collection completion varied between 45% and 88%. The intervention utilised 225 service hours. End point data at 6-months was available for 88.9% (intervention) and 84.8% (usual care) of participants. DISCUSSION: Despite higher rates of breastfeeding issues, women in the intervention group had similar rates of breastfeeding at 4- and 6-months and reduced hospital readmissions for breastfeeding related issues. Women indicated a preference for text and phone support once breastfeeding was established, however this preference may need to be balanced with more in-person support to ensure maximum benefits. CONCLUSION: Outcomes indicate a larger RCT using this protocol would be feasible, with an economic evaluation recommended. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Grace, Tegan AU - Grace T AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Australia; Mothers and Babies Research Centre, University of Newcastle, Australia; Reproductive and Family Health Research Program, Hunter Medical Research Institute, Australia. Electronic address: tegan.grace@newcastle.edu.au. FAU - Foureur, Maralyn AU - Foureur M AD - School of Nursing and Midwifery, University of Newcastle, Australia. FAU - Scurry, Susanna AU - Scurry S AD - School of Nursing and Midwifery, University of Newcastle, Australia. FAU - Schmied, Virginia AU - Schmied V AD - School of Nursing and Midwifery, Western Sydney University, Australia. FAU - Wang, Carol A AU - Wang CA AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Australia; Mothers and Babies Research Centre, University of Newcastle, Australia; Reproductive and Family Health Research Program, Hunter Medical Research Institute, Australia. FAU - Pennell, Craig E AU - Pennell CE AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, Australia; Mothers and Babies Research Centre, University of Newcastle, Australia; Reproductive and Family Health Research Program, Hunter Medical Research Institute, Australia; Department of Maternity and Gynaecology, John Hunter Hospital, Australia. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260428 PL - Netherlands TA - Women Birth JT - Women and birth : journal of the Australian College of Midwives JID - 101266131 SB - IM MH - Humans MH - Female MH - *Breast Feeding/statistics & numerical data MH - Pilot Projects MH - Feasibility Studies MH - *Continuity of Patient Care/organization & administration MH - Adult MH - *Postnatal Care/methods MH - Pregnancy MH - Australia MH - Infant, Newborn MH - Social Support OTO - NOTNLM OT - Breast Feeding OT - Feasibility Studies OT - Lactation OT - Midwifery OT - Pilot Projects OT - Pregnancy OT - Public Health OT - Randomised Controlled Trials COIS- Declaration of Competing Interest The authors have no competing interests to disclose EDAT- 2026/04/30 00:30 MHDA- 2026/06/11 06:38 CRDT- 2026/04/29 18:04 PHST- 2025/11/23 00:00 [received] PHST- 2026/03/15 00:00 [revised] PHST- 2026/04/17 00:00 [accepted] PHST- 2026/06/11 06:38 [medline] PHST- 2026/04/30 00:30 [pubmed] PHST- 2026/04/29 18:04 [entrez] AID - S1871-5192(26)00048-X [pii] AID - 10.1016/j.wombi.2026.102207 [doi] PST - ppublish SO - Women Birth. 2026 Jun;39(3):102207. doi: 10.1016/j.wombi.2026.102207. Epub 2026 Apr 28. PMID- 42054672 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260429 LR - 20260813 IS - 2291-9279 (Print) IS - 2291-9279 (Electronic) VI - 14 DP - 2026 Apr 29 TI - User Experience of a Virtual Reality-Based Treadmill for Children With a Chronic Disease Affecting Physical Health: Cross-Sectional Feasibility Study. PG - e82953 LID - 10.2196/82953 [doi] LID - e82953 AB - BACKGROUND: For children with chronic conditions affecting physical health and who require long-term care, the use of a connected treadmill for gait training as part of a home program can be a way to promote motivation in rehabilitation. Furthermore, the device must be evaluated by all user groups to ensure that its development best meets the rehabilitation needs of children. OBJECTIVE: The study aimed to assess the user experience of a connected treadmill called Amy-with both immersive and nonimmersive virtual reality-among children with a chronic disease impacting physical health, as well as their parents and therapists, to explore the feasibility and potential of such a device for home-based rehabilitation in this population. METHODS: Children with cerebral palsy, neuromuscular diseases, or obesity, along with one of their parents and rehabilitation therapists, were recruited. The study involved evaluating preexisting Amy solutions and collecting user experience feedback from participants with questionnaires. Amy solutions consisted of immersive virtual reality (using a virtual reality headset) and nonimmersive (tablet-based) games, both controlled through body movements on a treadmill conceived to train walking and balance. Questionnaires were the short version of the User Experience Questionnaire; the Usability Metric for User Experience; the Virtual Reality Sickness Questionnaire; a customized questionnaire evaluating comfort, fun, sense of presence and immersion; and a customized questionnaire evaluating parent's perception. RESULTS: Twenty-eight children, 28 parents, and 18 therapists participated in the study. Compared with User Experience Questionnaire benchmark data, the overall results with immersive and nonimmersive virtual reality in all participants were in the range of 10% best results or in the "excellent" category. The mean (95% CI) scores for each group of participants, with nonimmersive and immersive virtual reality, were as follows: 1.9 (1.6-2.2) and 2.1 (1.6-2.5) for children, 2.0 (1.7-2.2) and 2.3 (2.0-2.5) for parents, and 1.4 (1.1-1.7) and 1.4 (1.1-1.7) for therapists, respectively. User experience was significantly better for children and parents than for therapists (P adjusted .001). From the Usability Metric for User Experience, participants rated the Amy treadmill's usability as "good to excellent" on the System Usability Scale, regardless of whether immersive virtual reality was used. Immersive virtual reality was well tolerated by children. Children experienced immersive virtual reality positively in terms of comfort, immersion, presence, and fun. Parents' acceptability of the connected treadmill was positively assessed. CONCLUSIONS: This study is, to our knowledge, the first to assess the user experience of a playful treadmill-based virtual environment controller in children with chronic conditions affecting physical health in a user-centered and multidisciplinary team-based approach. This initial test demonstrates promising potential for using the connected treadmill as a rehabilitation tool. Therapists may need improvements to better meet their expectations, highlighting the importance of further iterations to align technological features and practical clinical context. CI - (c)Capucine Hennequin, Lena Carcreff, Adelie Christiaens, Mickael Dinomais, Josselin Demas. Originally published in JMIR Serious Games (https://games.jmir.org), 29.04.2026. FAU - Hennequin, Capucine AU - Hennequin C AUID- ORCID: 0009-0002-3565-4971 AD - Faculty of Medicine, University of Rouen Normandy, Rouen, France. AD - Rouen University Hospital, Rouen, France. FAU - Carcreff, Lena AU - Carcreff L AUID- ORCID: 0000-0003-0086-4944 AD - Department of Physical and Rehabilitation Medicine, Angers University Hospital, Angers, France. AD - Angers Living Lab in Hospital Geriatrics, Department of Geriatric Medicine and Rehabilitation, Angers University Hospital, Angers, France. AD - Angevin Research Laboratory for Systems Engineering, EA7315, University of Angers, Angers, France. FAU - Christiaens, Adelie AU - Christiaens A AUID- ORCID: 0009-0006-5247-8657 AD - Department of Physical and Rehabilitation Medicine, Angers University Hospital, Angers, France. AD - Angevin Research Laboratory for Systems Engineering, EA7315, University of Angers, Angers, France. FAU - Dinomais, Mickael AU - Dinomais M AUID- ORCID: 0000-0002-6980-1178 AD - Department of Physical and Rehabilitation Medicine, Angers University Hospital, Angers, France. AD - Angevin Research Laboratory for Systems Engineering, EA7315, University of Angers, Angers, France. FAU - Demas, Josselin AU - Demas J AUID- ORCID: 0000-0002-3760-4524 AD - Angevin Research Laboratory for Systems Engineering, EA7315, University of Angers, Angers, France. AD - Training Institutes, Laval Hospital Center, Laval, France. LA - eng PT - Journal Article DEP - 20260429 PL - Canada TA - JMIR Serious Games JT - JMIR serious games JID - 101645255 PMC - PMC13173068 OTO - NOTNLM OT - cerebral palsy OT - neuromuscular diseases OT - obesity OT - pediatrics OT - rehabilitation OT - user-centered design OT - virtual reality OT - walking COIS- Conflicts of Interest: The authors declare no conflicts of interest. The developers of the treadmill and virtual reality solution (EzyGain) were involved in the study design but not in the data collection, analysis, or writing of this paper. The funder had no involvement in the study design, data collection, analysis, interpretation, or the writing of the manuscript. EDAT- 2026/04/29 18:35 MHDA- 2026/04/29 18:36 PMCR- 2026/04/29 CRDT- 2026/04/29 16:53 PHST- 2025/09/02 00:00 [received] PHST- 2026/01/22 00:00 [accepted] PHST- 2026/04/29 18:36 [medline] PHST- 2026/04/29 18:35 [pubmed] PHST- 2026/04/29 16:53 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - v14i1e82953 [pii] AID - 10.2196/82953 [doi] PST - epublish SO - JMIR Serious Games. 2026 Apr 29;14:e82953. doi: 10.2196/82953. PMID- 42054666 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 28 DP - 2026 Apr 29 TI - Agile Development and Testing of a Gamified Human Milk Feeding Education Mobile App for Participants of the Special Supplemental Nutrition Program for Women, Infants, and Children: Co-Design Approach. PG - e80330 LID - 10.2196/80330 [doi] LID - e80330 AB - BACKGROUND: Human milk feeding and breastfeeding are the recommended standards for infant feeding. Nevertheless, breastfeeding rates in the United States remain below target levels, with disparities across racial, ethnic, and income groups. The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) plays a substantial role in reducing these disparities by providing lactation support to individuals with low income. With ongoing WIC modernization efforts, there is an opportunity to create and optimize technology solutions responsive to WIC participants' and staff's needs to increase access to the program and its services. OBJECTIVE: This study aimed to describe the development and pilot testing of Daily Drop, a gamified, low-bandwidth mobile app to provide human milk feeding education and support for WIC participants. METHODS: Guided by the 5-stage model for comprehensive research on telehealth, Daily Drop underwent 3 stages: concept development, service design, and preimplementation. Using a mixed methods approach, the project team sought feedback from WIC leadership and staff at the state and local levels, state IT staff, and WIC participants at each stage. Suggestions from stages 1 and 2 were incorporated into the testable app before field testing (stage 3). During field testing, participants and staff completed surveys across multiple time points and qualitative interviews to evaluate the app's feasibility, usability, and acceptability. Quantitative data were analyzed using descriptive statistics, and qualitative data were thematically analyzed. RESULTS: Key feedback from WIC participants and staff included providing flexibility for a variety of human milk feeding approaches (stage 1); and providing easily accessible educational information throughout gameplay, diversifying progress tracking to emphasize knowledge growth and expertise development, and including supportive or affirming messages for users (stage 2). During field testing (stage 3), >67% of WIC participants agreed with 7 out of 12 acceptability, satisfaction, and usability questions about the app, reiterated in interviews where they highlighted the simplicity of the app and how it increased their confidence to feed human milk. However, barriers to app use included a lack of reminders and repetitive information for parents with previous human milk feeding experience. Similarly, for WIC staff, mean scores for acceptability and feasibility were 3.8 (SD 1.0) and 4.4 (SD 0.6), respectively (max 5) at the early phase, but these scores declined over time. Staff recommendations included providing further, in-depth training to increase their familiarity with the app and reporting, and integrating the reports into WIC's management information system. CONCLUSIONS: The development of Daily Drop followed an agile development, co-design approach with the involvement of relevant key partners at all stages of development. Overall, Daily Drop was deemed acceptable, usable, and engaging by WIC participants and staff. Future research could focus on testing its effectiveness in improving human milk feeding behaviors and cost-effectiveness. CI - (c)Yarisbel Melo Herrera, Shannon Mitchell, Amy Malinowski, Catherine Wright, Marguerite Dibble, Patricia Cassi, Naina Qayyum, Erin Hennessy. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 29.04.2026. FAU - Melo Herrera, Yarisbel AU - Melo Herrera Y AUID- ORCID: 0000-0002-4075-7361 AD - Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States. FAU - Mitchell, Shannon AU - Mitchell S AUID- ORCID: 0009-0003-5283-973X AD - GameTheory Co, Burlington, VT, United States. FAU - Malinowski, Amy AU - Malinowski A AUID- ORCID: 0000-0002-1869-3365 AD - Special Supplemental Nutrition Program for Women, Infants, and Children (WIC), Vermont Department of Health, Waterbury, VT, United States. FAU - Wright, Catherine AU - Wright C AUID- ORCID: 0000-0003-3422-2413 AD - Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States. FAU - Dibble, Marguerite AU - Dibble M AUID- ORCID: 0009-0005-1843-3773 AD - GameTheory Co, Burlington, VT, United States. FAU - Cassi, Patricia AU - Cassi P AUID- ORCID: 0009-0002-0934-2923 AD - Special Supplemental Nutrition Program for Women, Infants, and Children (WIC), Vermont Department of Health, Waterbury, VT, United States. FAU - Qayyum, Naina AU - Qayyum N AUID- ORCID: 0009-0005-8668-8305 AD - Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States. FAU - Hennessy, Erin AU - Hennessy E AUID- ORCID: 0000-0001-9464-4947 AD - Gerald J. and Dorothy R. Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States. LA - eng PT - Journal Article DEP - 20260429 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 SB - IM MH - Humans MH - *Mobile Applications MH - Female MH - Infant MH - *Breast Feeding MH - *Food Assistance MH - *Milk, Human MH - Child MH - Adult PMC - PMC13173074 OTO - NOTNLM OT - WIC OT - agile development OT - app OT - breastfeeding OT - gamification OT - human milk feeding OT - mHealth OT - software testing COIS- Conflicts of Interest: YMH, AM, CW, PC, NQ, and EH have no conflicts of interest to declare. SM and MD are the Chief Operating Officer and Chief Executive Officer, respectively, of GameTheory Co and were involved in the development of the mobile app described in this manuscript. However, they were not involved in the field testing of the app to ensure that the data collection and analysis remained unbiased and solely focused on scientific integrity and Special Supplemental Nutrition Program for Women, Infants, and Children-related outcomes associated with US Department of Agriculture's funding. EDAT- 2026/04/29 18:35 MHDA- 2026/04/29 18:36 PMCR- 2026/04/29 CRDT- 2026/04/29 16:53 PHST- 2025/07/08 00:00 [received] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/04/29 18:36 [medline] PHST- 2026/04/29 18:35 [pubmed] PHST- 2026/04/29 16:53 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - v28i1e80330 [pii] AID - 10.2196/80330 [doi] PST - epublish SO - J Med Internet Res. 2026 Apr 29;28:e80330. doi: 10.2196/80330. PMID- 42054016 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260921 IS - 1465-3648 (Electronic) IS - 0268-1153 (Print) IS - 0268-1153 (Linking) VI - 41 IP - 3 DP - 2026 Mar 31 TI - The effect of a digital gamified breastfeeding counselling program on breastfeeding self-efficacy, breastfeeding success, and breast-related problems: a randomized controlled trial in Turkiye. LID - 10.1093/her/cyag014 [doi] LID - cyag014 AB - This single-site, pilot-scale randomized controlled study intended to evaluate the effects of a self-determination theory-informed (D6 gamification model-based) gamified breastfeeding counselling program on breastfeeding self-efficacy, breastfeeding success, and breast-related problems in postpartum participants. A pretest-posttest randomized controlled trial was conducted with 60 pregnant individuals recruited from a single university-affiliated private hospital in Turkiye, using a pilot-scale parallel group design. Participants were assigned to experimental (n = 30) and control (n = 30) groups by block randomization that was performed by an independent statistician. Due to the behavioural nature of the intervention, participant blinding was not feasible; however, outcome analyses were conducted by a blinded biostatistician. The intervention group received a digitally delivered gamified breastfeeding counselling program from gestational week 35 until week 2 postpartum, while the control group received routine prenatal and postnatal care. Data were obtained for validated measures of breastfeeding self-efficacy, breastfeeding success, and breast-related problems. Descriptive and inferential statistical analyses were conducted with SPSS 28.0 software. At week 2 postpartum, the mean breastfeeding self-efficacy scale-short form scores were significantly higher in the gamified counselling group than the control group (63.6 +/- 6.2 versus 54.3 +/- 8.4, P < .001, Cohen's d = 1.26). Breastfeeding performance also favoured the intervention group, with higher infant breastfeeding assessment tool scores (8.6 +/- 1.1 versus 7.3 +/- 1.4, P < .001) and LATCH breastfeeding assessment scores (9.3 +/- 0.7 versus 8.4 +/- 1.1, P = .002). Furthermore, breast fullness severity that was assessed using a dichotomous self-reported outcome (present/absent) checklist in which higher scores indicate more severe fullness, was lower in the intervention group than the control group (2.5 +/- 1.1 versus 4.0 +/- 1.2, P < .001). Gamified breastfeeding counselling was effective in enhancing breastfeeding self-efficacy and breastfeeding success and reduced common breast-related problems. These findings provide preliminary evidence supporting the feasibility and short-term benefits of integrating gamification-based strategies into breastfeeding education, warranting larger multicenter studies with extended follow-up. CI - (c) The Author(s) 2026. Published by Oxford University Press. FAU - Bulut, Ozlem Ulku AU - Bulut OU AUID- ORCID: 0000-0003-0810-3381 AD - Faculty of Health Sciences, Department of Midwifery, Lokman Hekim University, Sogutozu Mah., 2185, Cadde No: 20J, Cankaya, Ankara 06510, Turkiye. AD - PhD Student, Department of Medical Education, Gazi University, Emniyet Mah., Bandirma Cad. No: 6/1, Yenimahalle, Ankara 06560, Turkiye. FAU - Golbasi, Zehra AU - Golbasi Z AD - Faculty of Nursing, Lokman Hekim University, Sogutozu Mah., 2185, Cadde No: 20J, Cankaya, Ankara 06510, Turkiye. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Health Educ Res JT - Health education research JID - 8608459 SB - IM MH - Humans MH - *Breast Feeding/psychology MH - Female MH - *Self Efficacy MH - Adult MH - *Counseling/methods MH - Pregnancy MH - Pilot Projects MH - Postpartum Period MH - Young Adult PMC - PMC13127138 COIS- The authors declare that they have no conflicts of interest related to this study. All authors have completed the ICMJE disclosure forms, and no relevant financial or non-financial interests were reported. EDAT- 2026/04/29 12:43 MHDA- 2026/04/29 12:44 PMCR- 2026/04/29 CRDT- 2026/04/29 11:32 PHST- 2025/02/11 00:00 [received] PHST- 2026/03/07 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/04/29 12:44 [medline] PHST- 2026/04/29 12:43 [pubmed] PHST- 2026/04/29 11:32 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - 8664824 [pii] AID - cyag014 [pii] AID - 10.1093/her/cyag014 [doi] PST - ppublish SO - Health Educ Res. 2026 Mar 31;41(3):cyag014. doi: 10.1093/her/cyag014. PMID- 42053809 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261012 IS - 1435-165X (Electronic) IS - 1018-8827 (Print) IS - 1018-8827 (Linking) VI - 35 IP - 8 DP - 2026 Aug TI - Ultra-processed food consumption during pregnancy and emotional and behavioral problems in offspring. PG - 2633-2643 LID - 10.1007/s00787-026-03044-0 [doi] AB - Evidence on prenatal ultra-processed food (UPF) consumption and offspring psychopathological problems remains limited. Therefore, this study assessed the associations between UPF consumption during pregnancy and offspring emotional and behavioral problems. The potential impact of theoretically replacing UPFs with unprocessed or minimally processed foods was also examined using simulation models. The analyses included 201 mother-child pairs from the ECLIPSES study. Dietary intake was assessed using a validated food frequency questionnaire at 12, 24, and 36 weeks of gestation. UPF consumption (%grams/day) was estimated using the NOVA classification system. Children's behavior was assessed at age 4 using the parent-reported Child Behaviour Checklist (1.5 to 5 years), with outcomes defined as borderline/clinical scores. Multivariable-adjusted logistic regression models were fitted. Every 10% grams/day increase in prenatal UPF consumption was associated with higher odds of having children with borderline/clinical scores on several syndrome and broad-band scales: emotionally reactive (Odd ratios [OR]: 1.67; 95% Confidence interval [CI]: 1.06-2.63), aggressive behavior (OR 2.13; 95% CI: 1.18-3.84), internalizing problems (OR: 1.56 95%CI: 1.06-2.31), externalizing problems (OR: 2.00; 95% CI: 1.31-3.07) and total problems (OR: 1.68; 95%CI: 1.12-2.51). Associations were also observed with DSM-oriented scales, including depressive (OR: 2.08; 95%CI: 1.25-3.45), attention deficit/hyperactivity (OR: 1.71; 95%CI: 1.08-2.68) and oppositional defiant problems (OR: 1.85; 95%CI: 1.09-3.13). Replacing 10%grams/day of UPF with equal amounts of unprocessed or minimally processed foods was associated with lower likelihood of children presenting the aforementioned borderline/clinical scores. The findings suggest that prenatal UPF consumption might be associated with adverse emotional and behavioral outcomes in the offspring. CI - (c) 2026. The Author(s). FAU - Becerra-Tomas, Nerea AU - Becerra-Tomas N AUID- ORCID: 0000-0002-4429-6507 AD - Departament de Ciencies Mediques Basiques, Unitat de Salut Publica i Epidemiologia Nutricional, Nutrition and Mental Health (NUTRISAM) research group, Universitat Rovira i Virgili, Carrer St. Llorenc, 21, Reus, 43201, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain. FAU - Sans, Josefa Canals AU - Sans JC AUID- ORCID: 0000-0002-6209-9558 AD - Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain. AD - Department of Psychology, Nutrition and Mental Health (NUTRISAM) research group, Universitat Rovira i Virgili, Tarragona, Spain. AD - Department of Psychology, Research Center for Behavioral Assessment (CRAMC), Universitat Rovira i Virgili, Tarragona, Spain. FAU - Jardi, Cristina AU - Jardi C AUID- ORCID: 0000-0002-7946-1488 AD - Departament de Ciencies Mediques Basiques, Unitat de Salut Publica i Epidemiologia Nutricional, Nutrition and Mental Health (NUTRISAM) research group, Universitat Rovira i Virgili, Carrer St. Llorenc, 21, Reus, 43201, Spain. AD - Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain. FAU - Voltas, Nuria AU - Voltas N AUID- ORCID: 0000-0001-8855-0282 AD - Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain. AD - Department of Psychology, Nutrition and Mental Health (NUTRISAM) research group, Universitat Rovira i Virgili, Tarragona, Spain. AD - Department of Psychology, Research Center for Behavioral Assessment (CRAMC), Universitat Rovira i Virgili, Tarragona, Spain. FAU - Hernandez-Martinez, Carmen AU - Hernandez-Martinez C AUID- ORCID: 0000-0001-6328-8679 AD - Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain. AD - Department of Psychology, Nutrition and Mental Health (NUTRISAM) research group, Universitat Rovira i Virgili, Tarragona, Spain. AD - Department of Psychology, Research Center for Behavioral Assessment (CRAMC), Universitat Rovira i Virgili, Tarragona, Spain. FAU - Arija, Victoria AU - Arija V AUID- ORCID: 0000-0002-1758-0975 AD - Departament de Ciencies Mediques Basiques, Unitat de Salut Publica i Epidemiologia Nutricional, Nutrition and Mental Health (NUTRISAM) research group, Universitat Rovira i Virgili, Carrer St. Llorenc, 21, Reus, 43201, Spain. victoria.arija@urv.cat. AD - Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, Spain. victoria.arija@urv.cat. AD - Collaborative Group on Lifestyles, Nutrition, and Tobacco (CENIT), Institut d'Investigacio en Atencio Primaria IDIAP Jordi Gol, Institut Catala de la Salut (ICS), Reus, Spain. victoria.arija@urv.cat. LA - eng PT - Journal Article DEP - 20260429 PL - Germany TA - Eur Child Adolesc Psychiatry JT - European child & adolescent psychiatry JID - 9212296 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Prenatal Exposure Delayed Effects/epidemiology MH - Child, Preschool MH - *Fast Foods/adverse effects/statistics & numerical data MH - Male MH - *Child Behavior Disorders/epidemiology/etiology MH - Infant MH - Adult PMC - PMC13652858 OTO - NOTNLM OT - Behavioral problems OT - Child development OT - Pregnancy OT - Ultra-processed food COIS- Declarations. Ethical statement: The study was designed in agreement with the Declaration of Helsinki and the Tokyo Update. The protocol of the ECLIPSES study by the Ethical Committee of the Jordi Gol Institute for Primary Care Research and the Pere Virgili Institute for Health Research. Consent to participate: Written informed consent was obtained from all the participants in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/04/29 12:43 MHDA- 2026/10/09 17:34 PMCR- 2026/04/29 CRDT- 2026/04/29 11:13 PHST- 2025/07/31 00:00 [received] PHST- 2026/04/19 00:00 [accepted] PHST- 2026/10/09 17:34 [medline] PHST- 2026/04/29 12:43 [pubmed] PHST- 2026/04/29 11:13 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - 10.1007/s00787-026-03044-0 [pii] AID - 3044 [pii] AID - 10.1007/s00787-026-03044-0 [doi] PST - ppublish SO - Eur Child Adolesc Psychiatry. 2026 Aug;35(8):2633-2643. doi: 10.1007/s00787-026-03044-0. Epub 2026 Apr 29. PMID- 42053576 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 1747-4132 (Electronic) IS - 1747-4124 (Linking) VI - 20 IP - 5 DP - 2026 May TI - Exploring the efficacy and future prospects of nutritional and dietary therapies in Crohn's disease. PG - 425-437 LID - 10.1080/17474124.2026.2667874 [doi] AB - INTRODUCTION: Nutritional therapy has progressed from supportive care to a targeted strategy in inflammatory bowel disease (IBD), particularly Crohn's disease (CD). Exclusive enteral nutrition (EEN) is firmly established as a first-line induction therapy in pediatric CD, achieving remission rates comparable to corticosteroids while simultaneously supporting growth and promoting mucosal healing. AREAS COVERED: This review outlines enteral and dietary interventions in CD. A PubMed (MEDLINE) search identified relevant studies on nutritional and dietary interventions in CD published up to 17 August 2025. In children, EEN is validated; in adults, its use is more selective, with evidence supporting benefit in mild-to-moderate disease, intolerance to pharmacologic agents, and perioperative optimization. Elemental or low-residue formulas are particularly relevant for patients with stricturing disease or malnutrition. Partial enteral nutrition and structured exclusion diets, such as the Crohn's Disease Exclusion Diet (CDED), offer feasible long-term approaches. Regional differences persist, as Japan has established reimbursement pathways facilitating enteral nutrition, whereas Western countries generally prioritize pharmacologic therapies. EXPERT OPINION: Enteral nutrition remains a valuable therapeutic option in CD when applied to carefully selected patients. Although biologics and small molecules dominate current management, individualized patient selection, adherence support, and multidisciplinary education are critical to maximize its therapeutic impact. FAU - Yamamoto, Takayuki AU - Yamamoto T AUID- ORCID: 0000-0001-7551-5568 AD - Inflammatory Bowel Disease Center, Yokkaichi Hazu Medical Center, Yokkaichi, Japan. LA - eng PT - Journal Article PT - Review DEP - 20260430 PL - England TA - Expert Rev Gastroenterol Hepatol JT - Expert review of gastroenterology & hepatology JID - 101278199 RN - Pediatric Crohn's disease SB - IM MH - Humans MH - *Crohn Disease/therapy/diet therapy MH - *Enteral Nutrition MH - Treatment Outcome MH - Remission Induction MH - Elimination Diets MH - Child OTO - NOTNLM OT - Crohn's disease OT - Crohn's disease exclusion diet OT - dietary therapy OT - exclusive enteral nutrition OT - malnutrition OT - partial enteral nutrition EDAT- 2026/04/29 12:43 MHDA- 2026/05/11 13:00 CRDT- 2026/04/29 11:03 PHST- 2026/05/11 13:00 [medline] PHST- 2026/04/29 12:43 [pubmed] PHST- 2026/04/29 11:03 [entrez] AID - 10.1080/17474124.2026.2667874 [doi] PST - ppublish SO - Expert Rev Gastroenterol Hepatol. 2026 May;20(5):425-437. doi: 10.1080/17474124.2026.2667874. Epub 2026 Apr 30. PMID- 42052039 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Relationship between childcare workers' physical literacy and support for promoting children's physical activity. PG - 1807141 LID - 10.3389/fpubh.2026.1807141 [doi] LID - 1807141 AB - INTRODUCTION: Physical literacy (PL) is defined as "the motivation, confidence, physical competence, knowledge, and understanding required to value and take responsibility for engagement in physical activities for life." Previous research suggests that higher parental PL is associated with positive attitudes and involvement in children's physical activity. As approximately 90% of children in Japan attend early childhood education and care settings, the role of childcare workers in supporting children's physical activity has become increasingly important. Therefore, we aimed to examine the characteristics of childcare workers' PL and its association with their support for promoting children's physical activity. METHODS: Secondary data from 201 childcare workers provided by a company managing early childhood education and care facilities were used. PL was assessed using the Physical Literacy for Life self-assessment tool (PL4L). Support for promoting children's physical activity was assessed using five items from a previous study and an additional item developed for this study. The construct validity of the support items was examined using confirmatory factor analysis, and internal consistency was assessed using Cronbach's alpha. The Mann-Whitney U and Kruskal-Wallis tests were used to compare childcare workers' PL scores by gender, sports club participation at each school age, and stage of change for participation in physical activity. Structural equation modeling was used to examine whether childcare workers' PL was related to support for promoting children's physical activity. RESULTS: Childcare workers who had participated in sports clubs during junior high school, high school, or university tended to report higher PL scores than those who had not. PL scores differed by stage of change for participation in physical activity, with childcare workers in the Maintenance stage showing significantly higher total PL scores than those in the Pre-contemplation stage. Structural equation modeling showed an acceptable model fit and reasonable factor loadings, and the path coefficients from childcare workers' PL to support were statistically significant. DISCUSSION: Childcare workers' PL appears to be associated with their experience of sports club participation and stage of change for participation in physical activity. Enhancing childcare workers' PL may aid their support for promoting children's physical activity. CI - Copyright (c) 2026 Honda, Matsunaga, Matsui, Toyama and Suzuki. FAU - Honda, Sho AU - Honda S AD - Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. FAU - Matsunaga, Misaki AU - Matsunaga M AD - Juntendo Administration for Sports, Health and Medical Sciences, Tokyo, Japan. FAU - Matsui, Masahiro AU - Matsui M AD - Department of Child Psychiatry, Yokohama City University Hospital, Yokohama, Kanagawa, Japan. AD - Faculty of Health and Sports Science, Juntendo University, Chiba, Japan. FAU - Toyama, Kenta AU - Toyama K AD - Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. FAU - Suzuki, Koya AU - Suzuki K AD - Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. AD - Juntendo Administration for Sports, Health and Medical Sciences, Tokyo, Japan. AD - Faculty of Health and Sports Science, Juntendo University, Chiba, Japan. AD - Institute of Health and Sports Science & Medicine, Juntendo University, Chiba, Japan. LA - eng PT - Journal Article DEP - 20260413 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Male MH - Female MH - *Exercise MH - Japan MH - *Health Promotion MH - *Child Day Care Centers MH - Child MH - Child, Preschool MH - Adult MH - *Child Care MH - Surveys and Questionnaires PMC - PMC13111194 OTO - NOTNLM OT - Physical Literacy for Life self-assessment tool (PL4L) OT - childcare workers OT - early childhood education OT - physical literacy OT - structural equation modeling OT - support for promoting children's physical activity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author KS declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/04/29 12:25 MHDA- 2026/04/29 12:26 PMCR- 2026/04/13 CRDT- 2026/04/29 04:51 PHST- 2026/02/09 00:00 [received] PHST- 2026/03/09 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/04/29 12:26 [medline] PHST- 2026/04/29 12:25 [pubmed] PHST- 2026/04/29 04:51 [entrez] PHST- 2026/04/13 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1807141 [doi] PST - epublish SO - Front Public Health. 2026 Apr 13;14:1807141. doi: 10.3389/fpubh.2026.1807141. eCollection 2026. PMID- 42052031 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Associations of eHealth literacy, physical literacy and physical fitness among urban middle school students in Guiyang, China: a multi-school cross-sectional study. PG - 1762497 LID - 10.3389/fpubh.2026.1762497 [doi] LID - 1762497 AB - OBJECTIVE: To assess the overall levels, disparities, and interrelations of eHealth literacy and physical literacy among urban junior high school students in Guiyang, examine their associations with physical health status, and develop a multifactorial predictive model to inform evidence-based health promotion strategies targeting urban adolescents. METHODS: A stratified cluster sampling method was used to recruit students from grades 7 to 9 in multiple urban junior high schools across Guiyang. The study employed a cross-sectional quantitative design incorporating structured questionnaires and standardized physical fitness assessments. Validated instruments-including an established eHealth Literacy Scale and a physical literacy assessment tool-were used alongside data derived from the National Student Physical Fitness Standards. Demographic and familial educational background data were also collected. Descriptive statistics, non-parametric analyses, Spearman partial correlation, and multivariate logistic regression were conducted to systematically explore the relationships among eHealth literacy, physical literacy, and physical health levels. RESULTS: Urban junior high school students in Guiyang demonstrated generally above-average levels of eHealth literacy, though a substantial subset fell below the expected proficiency threshold. Statistically meaningful disparities in both eHealth and physical literacy were observed across gender, grade level, parental education, and the frequency of digital health information instruction provided by families and teachers (p < 0.05). A robust positive association was identified between eHealth literacy and physical literacy (r = 0.412, p < 0.001), both of which were positively linked to higher physical health status. Multivariate regression analysis indicated that higher levels of "application ability" within eHealth literacy and stronger "motor skills" and "movement skills" within physical literacy were significantly associated with a lower likelihood of poor physical health status and a greater probability of belonging to higher physical health categories. Additionally, "health-related lifestyle awareness" had an independent effect on maintaining or improving qualified physical health levels. CONCLUSION: The physical health of urban junior high school students in Guiyang is shaped not only by their physical literacy but also by their capacity to navigate and utilize digital health information. Higher levels of eHealth literacy may facilitate adolescents' ability to acquire and evaluate digital health information, which can further support the development of physical literacy and promote healthier behavioral patterns. Enhancing adolescent physical health therefore requires simultaneous investment in both digital health competencies and foundational physical literacy, supported by a coordinated framework across schools, families, and communities. This study elucidates the interactive dynamics among eHealth literacy, physical literacy, and physical health from an urban youth perspective, offering critical guidance for the design of localized digital health education, physical literacy enhancement, and integrated intervention strategies. CI - Copyright (c) 2026 Yuan, Luo and Wu. FAU - Yuan, Junfeng AU - Yuan J AD - School of Physical Education, Guizhou Normal University, Guiyang, China. FAU - Luo, Lin AU - Luo L AD - School of Physical Education, Guizhou Normal University, Guiyang, China. AD - Key Laboratory of Brain Function and Brain Disease Prevention of Guizhou Province, Guiyang, China. FAU - Wu, Rui AU - Wu R AD - Guiyang No. 19 Middle School, Guiyang, China. LA - eng PT - Journal Article DEP - 20260413 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - China MH - Male MH - *Health Literacy/statistics & numerical data MH - Female MH - Adolescent MH - Digital Health MH - *Physical Fitness MH - *Urban Population/statistics & numerical data MH - *Students/statistics & numerical data MH - Schools MH - Surveys and Questionnaires PMC - PMC13111474 OTO - NOTNLM OT - digital health education OT - eHealth literacy OT - health promotion OT - physical health OT - physical literacy OT - urban adolescents COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/29 12:25 MHDA- 2026/04/29 12:26 PMCR- 2026/04/13 CRDT- 2026/04/29 04:51 PHST- 2025/12/07 00:00 [received] PHST- 2026/03/08 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/04/29 12:26 [medline] PHST- 2026/04/29 12:25 [pubmed] PHST- 2026/04/29 04:51 [entrez] PHST- 2026/04/13 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1762497 [doi] PST - epublish SO - Front Public Health. 2026 Apr 13;14:1762497. doi: 10.3389/fpubh.2026.1762497. eCollection 2026. PMID- 42052024 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Central adiposity outperforms disordered eating behavior in predicting type 2 diabetes risk in young adults: an explainable machine learning approach. PG - 1778156 LID - 10.3389/fpubh.2026.1778156 [doi] LID - 1778156 AB - BACKGROUND: Disordered eating behaviors are often associated with adverse metabolic outcomes, yet their relationship with type 2 diabetes mellitus(T2DM) risk in young adults is less clear. This study aimed to evaluate the impact of disordered eating behaviors on diabetes risk among university students, using both traditional statistical methods and machine learning approaches. METHODS: A total of 1,302 university students participated in this cross-sectional study. Disordered eating behavior was assessed using the Eating Attitudes Test-40 (EAT-40), a validated screening tool for abnormal eating attitudes, while type 2 diabetes risk was estimated using the Finnish Diabetes Risk Score (FINDRISK), a widely used non-invasive instrument designed to estimate the 10-year risk of developing T2DM. Anthropometric measures were recorded according to standardized protocols. Bivariate associations were examined using correlation analysis, while multivariable regression and machine learning models (XGBoost) were applied to determine predictors of diabetes risk. RESULTS: Of the 1,302 participants, 90.8% were classified as low/mild risk, 6.2% as moderate risk, and 3.0% as high/very high risk according to FINDRISK. No significant correlation was found between EAT-40 scores and FINDRISK (r = 0.01, p = 0.755). In multivariable regression, waist-to-height ratio (beta = 1.42 per 0.05 increase, p < 0.001) and body mass index (beta = 0.31, p < 0.001) were the strongest predictors of diabetes risk. Machine learning models, particularly XGBoost (AUROC = 0.87), highlighted waist-to-height ratio as the most influential predictor. CONCLUSION: In young adults, central adiposity specifically waist-to-height ratio was the most significant predictor of T2DM risk, while disordered eating behavior had minimal independent impact. These findings suggest that simple anthropometric measures could be prioritized for early diabetes risk assessment over eating attitude screening. CI - Copyright (c) 2026 Alatas, Arslan, Kurt and Bentli. FAU - Alatas, Hacer AU - Alatas H AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Malatya Turgut Ozal University, Malatya, Turkiye. FAU - Arslan, Nurgul AU - Arslan N AD - Department of Nutrition and Dietetics, Ataturk Faculty of Health Sciences, Dicle University, Diyarbakir, Turkiye. FAU - Kurt, Harun AU - Kurt H AD - Malatya Provincial Health Directorate, Personnel Services Department, Malatya, Turkiye. FAU - Bentli, Serkan AU - Bentli S AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Malatya Turgut Ozal University, Malatya, Turkiye. LA - eng PT - Journal Article DEP - 20260413 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/epidemiology MH - Female MH - Male MH - Young Adult MH - Cross-Sectional Studies MH - *Feeding and Eating Disorders/epidemiology MH - *Machine Learning MH - Risk Factors MH - Risk Assessment MH - *Obesity, Abdominal/epidemiology MH - Adult MH - Universities MH - Students/statistics & numerical data MH - Adolescent MH - *Adiposity PMC - PMC13116002 OTO - NOTNLM OT - FINDRISK OT - disordered eating OT - machine learning OT - type 2 diabetes OT - university students COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/29 12:25 MHDA- 2026/04/29 12:26 PMCR- 2026/04/13 CRDT- 2026/04/29 04:51 PHST- 2025/12/30 00:00 [received] PHST- 2026/03/05 00:00 [revised] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/04/29 12:26 [medline] PHST- 2026/04/29 12:25 [pubmed] PHST- 2026/04/29 04:51 [entrez] PHST- 2026/04/13 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1778156 [doi] PST - epublish SO - Front Public Health. 2026 Apr 13;14:1778156. doi: 10.3389/fpubh.2026.1778156. eCollection 2026. PMID- 42051338 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260429 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Dietary intake, nutritional status and healthcare characteristics of mothers and newborn infants in a prospective cohort study (CHAMP) from a malnutrition-endemic region of Pakistan. PG - 1785862 LID - 10.3389/fnut.2026.1785862 [doi] LID - 1785862 AB - BACKGROUND: Dietary intake, nutritional status, healthcare access, and early-life exposures play a critical role in shaping infant growth and development. Recent evidence suggests that the impact is largely mediated by gut microbiome. The Child Health, Nutrition and Microbiome in Pakistan (the CHAMP study) is a longitudinal cohort study aiming to assess the bidirectional relationship between gut microbiome and infant growth and development in a cohort of children residing in malnutrition endemic areas of Pakistan. OBJECTIVES: The current study report the baseline sociodemographic, dietary, healthcare, and nutritional characteristics of mother-infant dyads participating in the CHAMP study. METHODS: Baseline data were collected from 70 mothers and 72 newborn infants recruited from rural communities in District Swat, Pakistan. Information on household socioeconomic status, maternal dietary intake, antenatal, delivery and postnatal care, infant feeding practices, morbidity, and anthropometric measurements was obtained using validated tools. Descriptive and sex-stratified analyses were conducted. RESULTS: Households were socioeconomically disadvantaged, with low parental education, large family size, and mean household income substantially below the national minimum wage. Maternal utilization and quality of antenatal and postnatal care were suboptimal, including limited completion of recommended antenatal visits. Dietary quality was also poor, and none of the mothers met the recommended minimum dietary diversity for women. Among infants, morbidity was common, with nearly half experiencing diarrheal illness or respiratory infections. Exclusive breastfeeding reported only in 43.1% of infants. Anthropometric assessment revealed evidence of early growth faltering, with 35.4% of infants were low-length-for-age with higher prevalence among females. CONCLUSION: These baseline findings highlight substantial socioeconomic vulnerability, poor maternal diet quality, gaps in maternal and infant healthcare, and early-life undernutrition in this rural Pakistani cohort. The study finding provides foundation for longitudinal analyses examining how these factors interact with gut microbiome development and child growth, informing and cost effective and culturally relevant intervention strategies. CI - Copyright (c) 2026 Shahzad, Saidal, Ismail, Tariq, Melhem, Iqbal, Khattak, Ahmad, Saeed, Ghani, Al Nabhani and Andrews. FAU - Shahzad, Muhammad AU - Shahzad M AD - Faculty of Dentistry, Zarqa University, Zarqa, Jordan. AD - Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan. FAU - Saidal, Ahsan AU - Saidal A AD - KMU Institute of Health Sciences, Swat, Pakistan. FAU - Ismail, Muhammad AU - Ismail M AD - Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan. FAU - Tariq, Kalsoom AU - Tariq K AD - Department of Biochemistry, Khyber Girls Medical College Peshawar, Peshawar, Pakistan. FAU - Melhem, Alaa' Lutfi AU - Melhem AL AD - Faculty of Dentistry, Zarqa University, Zarqa, Jordan. FAU - Iqbal, Khalid AU - Iqbal K AD - Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan. AD - Epidemiological Methods and Etiological Research, Leibniz Institute for Prevention Research and Epidemiology, Bremen, Germany. FAU - Khattak, Maria Ishaq AU - Khattak MI AD - Institute of Public Health and Social Sciences, Khyber Medical University, Peshawar, Pakistan. FAU - Ahmad, Habab Ali AU - Ahmad HA AD - Department of Biological and Health Sciences, Pak-Austria Fachhochschule Institute of Applied Sciences and Technology, Haripur, Pakistan. FAU - Saeed, Muhammad AU - Saeed M AD - Institute of Basic Medical Sciences, Khyber Medical University, Peshawar, Pakistan. FAU - Ghani, Mustajab AU - Ghani M AD - KMU Institute of Health Sciences, Swat, Pakistan. FAU - Al Nabhani, Ziad AU - Al Nabhani Z AD - Department of Visceral Surgery and Medicine, Bern University Hospital, Bern, Switzerland. AD - Maurice Muller Laboratories, Department for Biomedical Research, University of Bern, Bern, Switzerland. FAU - Andrews, Simon C AU - Andrews SC AD - School of Biological Sciences, Health and Life Sciences Building, University of Reading, Reading, United Kingdom. LA - eng PT - Journal Article DEP - 20260413 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13111393 OTO - NOTNLM OT - birth cohort OT - breastfeeding practices OT - dietary diversity OT - gut microbiome OT - infant growth OT - malnutrition OT - maternal nutrition OT - rural Pakistan COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/29 12:25 MHDA- 2026/04/29 12:26 PMCR- 2026/04/13 CRDT- 2026/04/29 04:44 PHST- 2026/01/12 00:00 [received] PHST- 2026/03/22 00:00 [revised] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/04/29 12:26 [medline] PHST- 2026/04/29 12:25 [pubmed] PHST- 2026/04/29 04:44 [entrez] PHST- 2026/04/13 00:00 [pmc-release] AID - 10.3389/fnut.2026.1785862 [doi] PST - epublish SO - Front Nutr. 2026 Apr 13;13:1785862. doi: 10.3389/fnut.2026.1785862. eCollection 2026. PMID- 42051283 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260429 LR - 20260813 IS - 1735-4587 (Print) IS - 2008-2215 (Electronic) IS - 1735-4587 (Linking) VI - 21 IP - 1 DP - 2026 Jan TI - Demographic and Family Factors Associated with Body Image Dissatisfaction among Adolescents in Tehran. PG - 69-79 LID - 10.18502/ijps.v21i1.20566 [doi] AB - Objective: Body image dissatisfaction is a prevalent concern among adolescents, with potential implications for mental and physical health. Understanding its correlates in diverse cultural contexts, such as Iran, is crucial for developing targeted interventions. This study aimed to investigate the demographic Body Max Index (BMI), gender, etc. socioeconomic status and family structure associated with body image dissatisfaction in a sample of adolescent students in Tehran, Iran. Method : This cross-sectional study included 1,430 students (grades 7, 8 and 9) from randomly selected schools in Tehran. Body image dissatisfaction was assessed using a validated international questionnaire measuring demographics, body perceptions, eating patterns, and family structures. Self-reported weight height values were used to calculate BMI. Misperceived body status was defined as discordance between self-perceived image and actual BMI category. Statistical analyses included chi-square tests, t-tests, and multivariate regression (SPSS v26). Results: A total of 1, 430 participants completed the questionnaires and the mean age of participants was (14.13 +/- 1.2), and 54.8% were females and 785 males (54.9%). The findings revealed that 59.1% of adolescents misperceived their body status. Female gender (OR = 1.5, 95% CI: 1.18-1.90, P = 0.001), lower family SES (socioeconomic status) (OR = 4.27, 95% CI: 1.87-9.74, P < 0.001), higher BMI (OR = 1.09, 95% CI: 1.06-1.12, P < 0.001), and non-biological family structures (OR = 0.79, 95% CI: 0.26-2.3, P = 0.05) were significantly associated with body dissatisfaction. Students living with stepparents or relatives reported lower body satisfaction compared to those living with biological parents. These findings underscore the importance of gender, socioeconomic status, family structure, and BMI as key factors influencing body image dissatisfaction among adolescents. Conclusion: These findings highlight the importance of gender, socioeconomic status and family structure in body dissatisfaction among adolescents. Importantly, these findings reflect the heightened challenges facing youth in the post-COVID-19 era, during which lifestyle changes, increased social media exposure, and altered social interactions have intensified body image concerns. Further research is needed to explore this correlation in more detail and to develop culturally appropriate interventions to promote positive body image. CI - Copyright (c) 2026 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences. FAU - Mohammadi, Mohammad Reza AU - Mohammadi MR AD - Psychiatry and Psychology Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. FAU - Zamani, Zahra AU - Zamani Z AD - Community Medicine Specialist, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. FAU - Najafi, Ali AU - Najafi A AD - Medical Library and Information Sciences, Tehran University of Medical Sciences, Tehran, Iran. FAU - Kafami, Zahra AU - Kafami Z AD - Research Centre for Child Psychiatry, University of Turku, Turku, Finland. AD - INVEST Flagship, University of Turku, Turku, Finland. FAU - Yavari, Ali AU - Yavari A AD - Plastic and Reconstructive Surgery Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. FAU - Akhondzadeh, Shahin AU - Akhondzadeh S AD - Psychiatry and Psychology Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran. LA - eng PT - Journal Article PL - Iran TA - Iran J Psychiatry JT - Iranian journal of psychiatry JID - 101302041 PMC - PMC13111964 OTO - NOTNLM OT - Adolescents OT - Body Image OT - Body Mass Index (BMI) OT - Dissatisfaction OT - Eating Disorders COIS- None. EDAT- 2026/04/29 12:25 MHDA- 2026/04/29 12:26 PMCR- 2026/01/01 CRDT- 2026/04/29 04:43 PHST- 2025/07/28 00:00 [received] PHST- 2025/09/28 00:00 [revised] PHST- 2025/10/05 00:00 [accepted] PHST- 2026/04/29 12:26 [medline] PHST- 2026/04/29 12:25 [pubmed] PHST- 2026/04/29 04:43 [entrez] PHST- 2026/01/01 00:00 [pmc-release] AID - IJPS-21-69 [pii] AID - 10.18502/ijps.v21i1.20566 [doi] PST - ppublish SO - Iran J Psychiatry. 2026 Jan;21(1):69-79. doi: 10.18502/ijps.v21i1.20566. PMID- 42051251 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260429 LR - 20260813 IS - 1178-7007 (Print) IS - 1178-7007 (Electronic) IS - 1178-7007 (Linking) VI - 19 DP - 2026 TI - Predictive Value of the second-Trimester Triglyceride-Glucose Index and Its Derived Indices for Macrosomia in Gestational Diabetes Mellitus. PG - 577687 LID - 10.2147/DMSO.S577687 [doi] LID - 577687 AB - BACKGROUND: Macrosomia is a major adverse outcome associated with gestational diabetes mellitus (GDM), primarily driven by insulin resistance (IR). The triglyceride-glucose (TyG) index is a well-established surrogate marker for insulin resistance; however, its predictive value when combined with obesity indicators remains incompletely defined. This study aimed to compare the predictive performance of the TyG index and its derived indices during the second trimester for the risk of macrosomia in GDM. METHODS: The TyG index, TyG body mass index (TyG-BMI), TyG waist circumference (TyG-WC), and TyG waist-to-height ratio (TyG-WHtR) were assessed at 24-28 weeks of gestation. Their associations with macrosomia were analyzed using binary logistic regression and restricted cubic spline (RCS) analysis. The predictive performance of these indices was compared using receiver operating characteristic (ROC) curves, integrated discrimination improvement (IDI), and net reclassification improvement (NRI). The associations between TyG and its derived indices and the risk of delivering a macrosomic infant were further explored across different subgroups. RESULTS: Logistic regression revealed that GDM women in the highest tertile had a 3.458- and 3.718-fold higher risks of delivering macrosomia compared to the lowest tertile for TyG-BMI and TyG-WC, respectively. RCS analysis showed a dose-response relationship (all P for overall < 0.001). Compared with the conventional TyG index, which had an area under the curve (AUC) of 0.596, both TyG-BMI (AUC = 0.682) and TyG-WC (AUC = 0.681) demonstrated significantly better performance (P < 0.01); furthermore, their superiority was confirmed by significant IDI and NRI values (P < 0.01). The association was more pronounced in primiparous women aged < 35 years (P < 0.05). CONCLUSION: Elevated second-trimester TyG index and its derived indices are associated with an increased risk of macrosomia in GDM women. TyG-BMI and TyG-WC outperformed the conventional TyG index and may serve as valuable supplementary markers for early risk stratification in GDM. CI - (c) 2026 Chen et al. FAU - Chen, Yiting AU - Chen Y AUID- ORCID: 0009-0004-9168-5478 AD - Department of Clinical Laboratory, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, Jiangsu Province, 210003, People's Republic of China. FAU - Li, Shuyu AU - Li S AUID- ORCID: 0009-0000-4533-3827 AD - Department of Clinical Laboratory, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, Jiangsu Province, 210003, People's Republic of China. FAU - Xiang, Lanlan AU - Xiang L AUID- ORCID: 0000-0001-9404-4132 AD - Department of Clinical Laboratory, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, Jiangsu Province, 210003, People's Republic of China. FAU - Zhu, Yitian AU - Zhu Y AUID- ORCID: 0000-0002-2627-6350 AD - Department of Clinical Laboratory, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, Jiangsu Province, 210003, People's Republic of China. FAU - Zeng, Yu AU - Zeng Y AUID- ORCID: 0000-0002-9978-8883 AD - Department of Clinical Laboratory, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, Jiangsu Province, 210003, People's Republic of China. FAU - Chen, Yajun AU - Chen Y AD - Department of Clinical Laboratory, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, Jiangsu Province, 210003, People's Republic of China. FAU - Zhong, Tianying AU - Zhong T AUID- ORCID: 0009-0002-9686-2221 AD - Department of Clinical Laboratory, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, Jiangsu Province, 210003, People's Republic of China. LA - eng PT - Journal Article DEP - 20260423 PL - New Zealand TA - Diabetes Metab Syndr Obes JT - Diabetes, metabolic syndrome and obesity : targets and therapy JID - 101515585 PMC - PMC13116517 OTO - NOTNLM OT - gestational diabetes mellitus OT - insulin resistance OT - macrosomia OT - predictive model OT - triglyceride-glucose index COIS- The authors report no conflicts of interest in this work. EDAT- 2026/04/29 12:25 MHDA- 2026/04/29 12:26 PMCR- 2026/04/23 CRDT- 2026/04/29 04:43 PHST- 2025/11/02 00:00 [received] PHST- 2026/04/10 00:00 [accepted] PHST- 2026/04/29 12:26 [medline] PHST- 2026/04/29 12:25 [pubmed] PHST- 2026/04/29 04:43 [entrez] PHST- 2026/04/23 00:00 [pmc-release] AID - 577687 [pii] AID - 10.2147/DMSO.S577687 [doi] PST - epublish SO - Diabetes Metab Syndr Obes. 2026 Apr 23;19:577687. doi: 10.2147/DMSO.S577687. eCollection 2026. PMID- 42050817 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260814 IS - 1942-5473 (Electronic) IS - 0164-1263 (Linking) VI - 48 IP - 2 DP - 2026 Mar 15 TI - Diagnostic Assessment of Ankyloglossia and Association With Infant Feeding Challenges: A Systematic Review and Meta-Analysis-Part 1. PG - 82-68E AB - Purpose: To assess the diagnostic criteria for restrictive lingual frenum and the association with feeding difficulties in mother-infant dyads. Methods: The protocol was registered with PROSPERO (CRD42024482618). Ovid MEDLINE, CINAHL, Embase, and Cochrane Library databases were searched from 1946 to May 2025 for studies meeting inclusion criteria. The population included mother-infant dyads with or without feeding difficulties, where infants had a restrictive frenum. Outcomes measured included diagnostic accuracy of tools assessing ankyloglossia and the association of ankyloglossia with feeding difficulties. Fourteen reviewers screened studies, performed data extraction, and assessed risk of bias using risk of bias and Office of Health Assessment and Translation tools. A Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach determined the quality of evidence. Results: Fourteen out of 20 included studies qualified for analysis, examining 5 ankyloglossia-specific diagnostic tools. For diagnosing ankyloglossia, the Bristol Tongue Assessment Tool/Tongue-tie and Breastfed Babies Assessment Tool (BTAT/TABBY) demonstrated high discriminative accuracy (AUC ROC=0.95, >2000 clinical cases), acceptable internal consistency (alpha=0.708) and strong correlation with the Hazelbaker Assessment Tool for Lingual Frenulum Function (HATLFF, r=0.89). Ten of the included studies examining feeding difficulties showed a trend favoring association with restrictive lingual frenum. Infants with ankyloglossia had a higher odds of maternally reported feeding difficulties (pooled OR= 5.57, 95% CI 0.44-70.02), though the effect did not reach statistical significance (P=0.18) and heterogeneity was substantial (I 2=96%). Conclusion: Very-low certainty evidence supports the use of standardized anatomical and functional (tongue mobility) assessments for restrictive lingual frenum. A consistent direction of association between restrictive lingual frenum and feeding difficulties was observed across studies, though pooled estimates did not reach statistical significance. FAU - Dhar, Vineet AU - Dhar V AD - Clinical Professor and Chair, Department of Orthodontics and Pediatric Dentistry, University of Maryland, School of Dentistry, Baltimore, MD, USA. FAU - Marghalani, Abdullah A AU - Marghalani AA AD - Associate Professor, Department of Preventive Dentistry, College of Dental Medicine, Umm Al-Qura University, Makkah, Saudi Arabia. FAU - Amini, Homa AU - Amini H AD - Clinical Professor, Division of Pediatric Dentistry, College of Dentistry, The Ohio State University and Department of Dentistry, Nationwide Children's Hospital, Columbus, Ohio, USA. FAU - Brickhouse, Tegwyn AU - Brickhouse T AD - Professor, Department of Pediatric Dentistry, School of Dentistry, Virginia Commonwealth University, Richmond, VA, USA. FAU - Caffrey, Erica AU - Caffrey E AD - Clinical Assistant Professor, Department of Orthodontics and Pediatric Dentistry, University of Maryland, School of Dentistry, Baltimore, MD, USA. FAU - Jayaraman, Jayakumar AU - Jayaraman J AD - Pediatric Dentist in Private Practice, Richmond, VA, USA. FAU - Keels, Martha Ann AU - Keels MA AD - Adjunct Associate Professor, Department of Pediatrics, Duke University, Durham, NC and an Adjunct Professor, Department of Pediatric, University of North Carolina, Chapel Hill, NC, USA. FAU - Messner, Anna AU - Messner A AD - Professor, Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas, USA. FAU - Patterson, Kimberly K AU - Patterson KK AD - Clinical Associate Professor, and interim chair, Department of Orthodontics and Pediatric Dentistry, Stony Brook School of Dental Medicine, Stony Brook, NY, USA. FAU - Raol, Nikhila AU - Raol N AD - Associate Professor, Department of Otolaryngology-Head and Neck Surgery, Baylor College of Medicine/Texas Children's Hospital, Houston, Texas, USA. FAU - Shrestha, Poojan AU - Shrestha P AD - Associate Professor, Department of Pediatric Dentistry and Dental Public Health, Adams School of Dentistry and an Adjunct Associate Professor, Department of Epidemiology Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA. FAU - Stark, Christopher M AU - Stark CM AD - Neonatologist, Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, USA. FAU - Susarla, Harlyn K AU - Susarla HK AD - Pediatric Dentist, Department of Dentistry, Seattle Children???s Hospital and a Affiliate Assistant Professor, University of Washington School of Dentistry, Seattle, WA, USA. FAU - Thomas, Jennifer AU - Thomas J AD - Staff Pediatrician, Department of Pediatrics, Advocate Aurora Health, Milwaukee, WI, USA. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review PL - United States TA - Pediatr Dent JT - Pediatric dentistry JID - 7909102 SB - IM MH - Humans MH - *Ankyloglossia/diagnosis/complications MH - Infant MH - Lingual Frenum/abnormalities MH - Breast Feeding EDAT- 2026/04/29 06:32 MHDA- 2026/04/29 06:33 CRDT- 2026/04/29 00:43 PHST- 2026/04/29 06:33 [medline] PHST- 2026/04/29 06:32 [pubmed] PHST- 2026/04/29 00:43 [entrez] PST - ppublish SO - Pediatr Dent. 2026 Mar 15;48(2):82-68E. PMID- 42050668 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260702 LR - 20260813 IS - 2055-5784 (Print) IS - 2055-5784 (Electronic) IS - 2055-5784 (Linking) VI - 12 IP - 1 DP - 2026 Apr 29 TI - Feasibility and perceived impact of a clinician-led bimanual training program using joystick-operated ride-on toys incorporated into an intensive task-oriented hybrid summer camp for children with unilateral cerebral palsy. LID - 10.1186/s40814-026-01824-8 [doi] LID - 92 AB - BACKGROUND: Children with Unilateral Cerebral Palsy (UCP) have significant limitations in upper extremity (UE) function impacting their independence and quality of life. Our study objectives were to assess (a) the feasibility and acceptability of incorporating a novel, bimanual ride-on-toy navigation (RNT) training program within a 3-week intensive, hybrid UE training camp (modified constraint induced movement therapy + bimanual training) and (b) the combined benefits of the comprehensive camp training model as perceived by clinicians. METHODOLOGY: We employed a single-group, pretest-posttest design. Ten children with UCP (M(SD): 6.99(2.13) years) and 6 clinicians/camp staff were recruited through convenience sampling from an annually held intensive therapy camp for children with UCP. In the 3-week camp, children practiced goal-oriented and task-focused activities for 6 h/day (5 h of UE practice with a constraint on the less-affected arm and 1-h of bimanual practice without the constraint). Following an initial training session, camp staff delivered fourteen RNT sessions (~ 20 min/session) per child over the 3 weeks as part of the bimanual portion of the camp. Feasibility and acceptability of the RNT program were assessed by monitoring adherence, through child and camp staff exit questionnaires, the Physical Activity Enjoyment Scale, and video-based behavioral coding. Clinician-perceived benefits of the overall camp programming, inclusive of RNT, was assessed using an exit questionnaire administered with camp staff and the ABILHAND-Kids Questionnaire. Given the pilot nature of this study and the small sample size, we report descriptive data, effect sizes, and 95% confidence intervals around the effect sizes. RESULTS: All 10 participants completed the study (Adherence: Mean(SD): 90.7% (13.5%)). Staff were able to successfully deliver RNT with minimal issues and wanted to repeat it in subsequent camp iterations. Children found RNT enjoyable and were highly engaged across sessions. In combination with other camp programming, RNT led to clinician-perceived improvements in children's bimanual function and spontaneous affected UE use during daily activities. CONCLUSIONS: Our work suggests that RNT is an engaging, versatile, and easy-to-implement therapy adjunct that clinicians may use to incentivize affected UE use and motor practice in children with UCP. CI - (c) 2026. The Author(s). FAU - Kataria, Kush AU - Kataria K AD - Physical Therapy Program, Department of Kinesiology, University of Connecticut, Storrs, CT, USA. FAU - Kumavor, Patrick D AU - Kumavor PD AD - Biomedical Engineering Department, University of Connecticut, Storrs, CT, USA. FAU - Srinivasan, Sudha AU - Srinivasan S AUID- ORCID: 0000-0003-4594-2547 AD - Physical Therapy Program, Department of Kinesiology, University of Connecticut, Storrs, CT, USA. sudha.srinivasan@uconn.edu. AD - Institute for Collaboration on Health, Intervention, and Policy (InCHIP), University of Connecticut, Storrs, CT, USA. sudha.srinivasan@uconn.edu. AD - Institute for the Brain and Cognitive Sciences (IBACS), University of Connecticut, Storrs, CT, USA. sudha.srinivasan@uconn.edu. LA - eng PT - Journal Article DEP - 20260429 PL - England TA - Pilot Feasibility Stud JT - Pilot and feasibility studies JID - 101676536 PMC - PMC13326004 OTO - NOTNLM OT - Bimanual training OT - Clinician-delivered training OT - Hemiplegia OT - Novel intervention OT - Ride-on toys OT - Technology-based therapy adjunct OT - Unilateral cerebral palsy COIS- Declarations. Ethics approval and consent to participate: The Internal Review Board (IRB) (IRB#: H21-0019) at the University of Connecticut approved the study and all procedures have been followed per the approved IRB guidelines. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/04/29 06:34 MHDA- 2026/04/29 06:35 PMCR- 2026/04/29 CRDT- 2026/04/29 00:17 PHST- 2025/07/14 00:00 [received] PHST- 2026/04/12 00:00 [accepted] PHST- 2026/04/29 06:35 [medline] PHST- 2026/04/29 06:34 [pubmed] PHST- 2026/04/29 00:17 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - 10.1186/s40814-026-01824-8 [pii] AID - 1824 [pii] AID - 10.1186/s40814-026-01824-8 [doi] PST - epublish SO - Pilot Feasibility Stud. 2026 Apr 29;12(1):92. doi: 10.1186/s40814-026-01824-8. PMID- 42050539 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1546-0096 (Electronic) IS - 1546-0096 (Linking) VI - 24 IP - 1 DP - 2026 Apr 28 TI - Markerless gait analysis for children and adolescents with juvenile idiopathic arthritis using a machine learning pipeline. LID - 10.1186/s12969-026-01211-w [doi] LID - 29 AB - BACKGROUND: Musculoskeletal diseases, such as Juvenile Idiopathic Arthritis (JIA), can lead to altered joint mobility and changes in gait pattern. While marker-based motion capture systems are considered the gold standard, their use is limited by high costs, technical complexity, time-intensive procedures, and specialized staff requirements. This study proposes and evaluates the feasibility of a markerless gait analysis approach for children of all ages, based on a machine learning pipeline, validates it against marker-based systems, and describes JIA-related gait differences. METHODS: Sagittal-plane gait videos were recorded using a standardized setup. A Mask R-CNN-based detector generated a bounding box around the body in each video frame. Within this box, a TCFormer model identified positions of predefined anatomical landmarks. Joint angles were computed from these landmarks on a frame-by-frame basis and assembled into continuous gait cycle trajectories. For validation, a subset of 12 participants was recorded simultaneously using a marker-based motion capture system and conventional video-recording. To ensure direct comparability between the two methods, physical markers in video-recordings were automatically detected and removed using a deep learning-based object detection and inpainting approach. Statistical comparisons were performed using Statistical Parametric Mapping. The estimated kinematic data were compared between JIA patients with lower-extremity involvement and typically developing (TD) peers, stratified by age and disease activity. RESULTS: Videos from 108 participants (60 JIA; 48 TD; age 1.8-17.4 years) were included. There was robust agreement between joint movement patterns of the markerless and the marker-based approach. Across all age groups, JIA patients with active arthritis had a reduced knee range of motion compared to TD (46.3[Formula: see text] vs. 49.8[Formula: see text]). Overall, differences in joint angle trajectories between groups remained limited. CONCLUSIONS: The proposed single-camera, markerless pipeline can provide reliable and valid gait data using standard video equipment in children. Differences in gait patterns between JIA patients and TD peers were generally small, likely due to effective disease control. This method is adaptable across all ages, may facilitate enhanced gait monitoring, increase knowledge of functional abnormalities in JIA, and support therapeutic decisions. In the long run, it may also reduce costs by lowering infrastructure and setup requirements. FAU - Behl, Aseem AU - Behl A AD - Faculty of Economics and Social Sciences, University of Tubingen, Nauklerstr. 47, 72074, Tubingen, Germany. FAU - Papies, Dominik AU - Papies D AD - Faculty of Economics and Social Sciences, University of Tubingen, Nauklerstr. 47, 72074, Tubingen, Germany. AD - Machine Learning Cluster of Excellence, University of Tubingen, Tubingen, Germany. FAU - Ilg, Winfried AU - Ilg W AD - Section Computational Sensomotorics, Hertie Institute for Clinical Brain Research, Otfried-Muller-Str. 27, 72076, Tubingen, Germany. AD - Centre for Integrative Neuroscience (CIN), University of Tubingen, Otfried-Muller-Str. 25, 72076, Tubingen, Germany. FAU - Kraft, Mareen AU - Kraft M AD - Clinic for Paediatrics and Adolescent Medicine, Department of Neuropaediatrics, General Paediatrics, Diabetology, Endocrinology, Social Paediatrics, University Hospital Tubingen, Hoppe-Seyler-Str. 1, 72076, Tubingen, Germany. FAU - Bevot, Andrea AU - Bevot A AD - Clinic for Paediatrics and Adolescent Medicine, Department of Neuropaediatrics, General Paediatrics, Diabetology, Endocrinology, Social Paediatrics, University Hospital Tubingen, Hoppe-Seyler-Str. 1, 72076, Tubingen, Germany. FAU - Hansmann, Sandra AU - Hansmann S AD - Clinic for Paediatrics and Adolescent Medicine, Department of Neuropaediatrics, General Paediatrics, Diabetology, Endocrinology, Social Paediatrics, University Hospital Tubingen, Hoppe-Seyler-Str. 1, 72076, Tubingen, Germany. sandra.hansmann@med.uni-tuebingen.de. LA - eng PT - Journal Article DEP - 20260428 PL - England TA - Pediatr Rheumatol Online J JT - Pediatric rheumatology online journal JID - 101248897 SB - IM MH - Humans MH - *Arthritis, Juvenile/physiopathology MH - Child MH - *Gait Analysis/methods MH - Female MH - Motion Capture MH - Male MH - Adolescent MH - *Machine Learning MH - Biomechanical Phenomena MH - Video Recording MH - Child, Preschool MH - Feasibility Studies MH - *Gait/physiology PMC - PMC13126831 OTO - NOTNLM OT - Clinical monitoring OT - Deep learning OT - Gait analysis OT - Juvenile Idiopathic Arthritis OT - Markerless motion capture COIS- Declarations. Ethics approval and consent to participate: This observational study was conducted following the principles of good clinical practice, the Declaration of Helsinki, current ethical standards, and was approved by the Ethics Committee at the Medical Faculty and the University Hospital Tuebingen (001/2020BO1 and 234/2021BO2). Consent for publication: Written informed consent was obtained from the participant and her parents for publication of the images. A copy of the written consent is available. Competing interests: The authors declare no competing interests. EDAT- 2026/04/29 06:32 MHDA- 2026/06/27 18:36 PMCR- 2026/04/28 CRDT- 2026/04/29 00:10 PHST- 2025/09/27 00:00 [received] PHST- 2026/03/26 00:00 [accepted] PHST- 2026/06/27 18:36 [medline] PHST- 2026/04/29 06:32 [pubmed] PHST- 2026/04/29 00:10 [entrez] PHST- 2026/04/28 00:00 [pmc-release] AID - 10.1186/s12969-026-01211-w [pii] AID - 1211 [pii] AID - 10.1186/s12969-026-01211-w [doi] PST - epublish SO - Pediatr Rheumatol Online J. 2026 Apr 28;24(1):29. doi: 10.1186/s12969-026-01211-w. PMID- 42049579 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260802 IS - 1871-403X (Print) IS - 1871-403X (Linking) VI - 20 IP - 3 DP - 2026 May-Jun TI - Is there a relationship between culinary skills and overweight/ obesity across life stages? A systematic review. PG - 168-175 LID - S1871-403X(26)00038-4 [pii] LID - 10.1016/j.orcp.2026.04.004 [doi] AB - INTRODUCTION: Obesity is a public health problem that affects millions of people worldwide, but its relationship with culinary skills has not yet been elucidated. This systematic review investigated the relationship between culinary skills and the prevalence of overweight and obesity among adolescents, adults, and older adults. We hypothesize that low cooking skills are associated with a higher prevalence of overweight and obesity across different life stages. METHODS: We searched the PubMed, Embase, and Web of Science databases from July to August 2024. The risk of bias assessment was performed using the Joanna Briggs Institute (JBI) tools. RESULTS: Five studies (three cross-sectional and two cohort) were included, totaling 53,557 subjects from Brazil, Italy, Canada, Japan, and France. The studies used body mass index or waist circumference to assess overweight and obesity. Culinary skills were evaluated using various non-standardized questionnaires covering knowledge, culinary techniques, cooking frequency, and ingredients used. One cohort study reported a negative association between culinary skills and overweight/obesity in adults. Conversely, two cross-sectional and cohort studies identified a positive association among adolescents and adults. CONCLUSIONS: The relationship between culinary skills and overweight/obesity remains inconclusive across the studies. We encourage future research to understand this relationship across different life stages better and to validate appropriate tools for evaluating culinary skills. CI - Copyright (c) 2026 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved. FAU - de Morais, Rafaela Nogueira Gomes AU - de Morais RNG AD - Department of Nutrition and Health, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil. Electronic address: rafaela.morais@ufv.br. FAU - Ribeiro, Guilherme Jose Silva AU - Ribeiro GJS AD - Department of Nutrition and Health, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil. Electronic address: guilherme.j.ribeiro@ufv.br. FAU - de Novaes, Juliana Farias AU - de Novaes JF AD - Department of Nutrition and Health, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil. Electronic address: jnovaes@ufv.br. FAU - Rocha, Daniela Mayumi Usuda Prado AU - Rocha DMUP AD - Laboratory of Clinical Analysis and Genomics, Department of Nutrition and Health, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil; Laboratory of Energy Metabolism and Body Composition, Department of Nutrition and Health, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil; Institute of Public Policies and Sustainable Development, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil. Electronic address: mayumi.dani@gmail.com. FAU - Kravchychyn, Ana Claudia Pelissari AU - Kravchychyn ACP AD - Laboratory of Clinical Analysis and Genomics, Department of Nutrition and Health, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil; Laboratory of Energy Metabolism and Body Composition, Department of Nutrition and Health, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil. Electronic address: ana.pelissari@ufv.br. FAU - Hermsdorff, Helen Hermana Miranda AU - Hermsdorff HHM AD - Laboratory of Clinical Analysis and Genomics, Department of Nutrition and Health, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil; Laboratory of Energy Metabolism and Body Composition, Department of Nutrition and Health, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil; Institute of Public Policies and Sustainable Development, Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil. Electronic address: helenhermana@ufv.br. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20260428 PL - Netherlands TA - Obes Res Clin Pract JT - Obesity research & clinical practice JID - 101303911 SB - IM MH - Humans MH - *Overweight/epidemiology MH - *Obesity/epidemiology MH - *Cooking/methods MH - Adolescent MH - Body Mass Index MH - Adult MH - Cross-Sectional Studies MH - Prevalence MH - Female MH - Aged MH - Male OTO - NOTNLM OT - Cooking OT - Culinary nutrition OT - Dietitians OT - Health education OT - Overweight COIS- Declaration of Competing Interest The authors declare no conflict of interest. EDAT- 2026/04/29 00:34 MHDA- 2026/06/13 00:39 CRDT- 2026/04/28 21:52 PHST- 2025/01/27 00:00 [received] PHST- 2026/02/01 00:00 [revised] PHST- 2026/04/19 00:00 [accepted] PHST- 2026/06/13 00:39 [medline] PHST- 2026/04/29 00:34 [pubmed] PHST- 2026/04/28 21:52 [entrez] AID - S1871-403X(26)00038-4 [pii] AID - 10.1016/j.orcp.2026.04.004 [doi] PST - ppublish SO - Obes Res Clin Pract. 2026 May-Jun;20(3):168-175. doi: 10.1016/j.orcp.2026.04.004. Epub 2026 Apr 28. PMID- 42049389 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260814 IS - 2059-7908 (Print) IS - 2059-7908 (Electronic) IS - 2059-7908 (Linking) VI - 11 IP - 4 DP - 2026 Apr 28 TI - Haemoglobin concentration thresholds that discriminate functional outcomes among children aged 6-30 months in eight countries: a pooled analysis of individual participant data. LID - 10.1136/bmjgh-2024-015866 [doi] LID - e015866 AB - INTRODUCTION: The WHO cut-offs to define anaemia among children (haemoglobin, Hb <105 g/L in 6-23 months and <110 g/L in 24-59 months) are based on the distribution of Hb concentrations in a healthy population. Our objective was to identify Hb values that best discriminate functional outcomes among children aged 6-30 months. METHODS: We used previously compiled datasets from an individual participant data meta-analysis of effects of small quantity lipid-based nutrient supplements. Participants were eligible for this pooled analysis if they had Hb measured at 6-30 months and data on at least one functional outcome of interest, which included physical activity and sleep patterns, and language, socioemotional and motor development. We stratified the datasets by child age in 3-month intervals and analysed associations of Hb with both concurrent and subsequently measured (longitudinal) outcomes. If Hb significantly discriminated the 25th, 50th or 75th percentile of the outcome based on the pooled area under the receiver operating characteristic curve (AUC), we identified the Hb value with the highest concordance probability as the best discriminatory threshold. RESULTS: 11 datasets from 8 countries including 27 626 children were analysed. Hb significantly discriminated 21 of 47 concurrent and 11 of 32 longitudinal Hb-outcome associations. Best Hb discriminatory thresholds ranged from 102 to 111 g/L for concurrent physical activity outcomes, 103-116 g/L for concurrent developmental outcomes, and 109-117 g/L for longitudinal developmental outcomes. The I(2) for the pooled AUC analysis indicated generally low to moderate heterogeneity across studies. CONCLUSIONS: The current WHO cut-offs to define anaemia among children are in the middle to upper range of Hb values that best discriminate concurrent physical activity and development, and are in the lower range of values that best discriminate subsequent child development. Along with other types of evidence, this study provides additional evidence to inform Hb cut-offs to define anaemia among young children. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Prado, Elizabeth L AU - Prado EL AUID- ORCID: 0000-0002-5388-081X AD - Institute for Global Nutrition & Department of Nutrition, University of California Davis, Davis, California, USA. FAU - Larson, Leila M AU - Larson LM AUID- ORCID: 0000-0002-2570-7323 AD - Department of Health Promotion, Education, and Behavior, University of South Carolina, Columbia, South Carolina, USA larsonl@mailbox.sc.edu. FAU - Arnold, Charles D AU - Arnold CD AD - Institute for Global Nutrition & Department of Nutrition, University of California Davis, Davis, California, USA. FAU - Wessells, K Ryan AU - Wessells KR AD - Institute for Global Nutrition & Department of Nutrition, University of California Davis, Davis, California, USA. FAU - Shankar, Anuraj H AU - Shankar AH AD - Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK. AD - Oxford Clinical Research Unit Indonesia, Central Jakarta, Indonesia. FAU - Adu-Afarwuah, Seth AU - Adu-Afarwuah S AD - Department of Nutrition and Food Science, University of Ghana, Accra, Ghana. FAU - Arnold, Benjamin F AU - Arnold BF AD - Francis I. Proctor Foundation, University of California San Francisco, San Francisco, California, USA. FAU - Ashorn, Per AU - Ashorn P AUID- ORCID: 0000-0003-2311-2593 AD - Center for Child, Adolescent and Maternal Health Research, Tampere University Faculty of Medicine and Health Technology, Tampere, Finland. AD - Department of Paediatrics, Tampere University Hospital, Tampere, Finland. FAU - Ashorn, Ulla AU - Ashorn U AD - Center for Child, Adolescent and Maternal Health Research, Tampere University Faculty of Medicine and Health Technology, Tampere, Finland. FAU - Becquey, Elodie AU - Becquey E AD - Nutrition, Diets, and Health Unit, International Food Policy Research Institute, Washington, District of Columbia, USA. FAU - Brown, Kenneth H AU - Brown KH AD - Institute for Global Nutrition & Department of Nutrition, University of California Davis, Davis, California, USA. AD - Helen Keller International, New York, New York, USA. FAU - Chandna, Jaya AU - Chandna J AD - Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. FAU - Chasekwa, Bernard AU - Chasekwa B AD - Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe. FAU - Fan, Yue-Mei AU - Fan YM AUID- ORCID: 0000-0002-3241-6225 AD - Center for Child, Adolescent and Maternal Health Research, Tampere University Faculty of Medicine and Health Technology, Tampere, Finland. FAU - Galasso, Emanuela AU - Galasso E AD - Development Research Group, World Bank, Washington, District of Columbia, USA. FAU - Hess, Sonja Y AU - Hess SY AD - Institute for Global Nutrition & Department of Nutrition, University of California Davis, Davis, California, USA. FAU - Huybregts, Lieven AU - Huybregts L AUID- ORCID: 0000-0002-3068-2853 AD - Nutrition, Diets, and Health Unit, International Food Policy Research Institute, Washington, District of Columbia, USA. FAU - Jannat, Kaniz AU - Jannat K AD - School of Health Sciences, Western Sydney University, Penrith, New South Wales, Australia. FAU - Yakes Jimenez, Elizabeth AU - Yakes Jimenez E AD - Departments of Pediatrics and Internal Medicine and College of Population Health, The University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA. FAU - Lartey, Anna AU - Lartey A AD - Department of Nutrition and Food Science, University of Ghana, Accra, Ghana. FAU - Le Port, Agnes AU - Le Port A AD - Montpellier Interdisciplinary Center on Sustainable Agri food systems, French National Research Institute for Sustainable Development, Marseille, France. FAU - Leroy, Jef L AU - Leroy JL AUID- ORCID: 0000-0001-9371-3832 AD - Nutrition, Diets, and Health Unit, International Food Policy Research Institute, Washington, District of Columbia, USA. FAU - Luby, Stephen P AU - Luby SP AD - Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, California, USA. FAU - Maleta, Kenneth AU - Maleta K AD - Department of Public Health, School of Public Health and Family Medicine, University of Malawi College of Medicine, Blantyre, Malawi. FAU - Matchado, Andrew AU - Matchado A AD - Department of Public Health, School of Global and Public Health, Kamuzu University of Health Sciences, Blantyre, Malawi. FAU - Matias, Susana L AU - Matias SL AD - Department of Medical Biology and Nutrition, University of California Berkeley, Berkeley, California, USA. FAU - Mridha, Malay Kanti AU - Mridha MK AD - Center for Non-Communicable Diseases and Nutrition, BRAC University James P Grant School of Public Health, Dhaka, Bangladesh. FAU - Mutasa, Kuda AU - Mutasa K AD - Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe. FAU - Null, Clair AU - Null C AD - Mathematica Inc, Washington, Washington, USA. FAU - Okronipa, Harriet AU - Okronipa H AD - Department of Nutritional Sciences, Oklahoma State University, Stillwater, Oklahoma, USA. FAU - Ouedraogo, Jean Bosco AU - Ouedraogo JB AUID- ORCID: 0000-0003-0412-8733 AD - Health Sciences Research Institute, Bobo-Dioulasso, Burkina Faso. FAU - Pickering, Amy AU - Pickering A AD - Tufts University School of Engineering, Medford, Massachusetts, USA. FAU - Phuka, John AU - Phuka J AD - Department of Public Health, School of Public Health and Family Medicine, University of Malawi College of Medicine, Blantyre, Malawi. FAU - Pulakka, Anna AU - Pulakka A AD - Research Unit of Population Health, University of Oulu, Oulu, Finland. FAU - Ratsifandrihamanana, Lisy AU - Ratsifandrihamanana L AD - Centre Medico-Educatif "Les Orchidees Blanches", Antananarivo, Madagascar. FAU - Stewart, Christine P AU - Stewart CP AD - Institute for Global Nutrition & Department of Nutrition, University of California Davis, Davis, California, USA. FAU - Tofail, Fahmida AU - Tofail F AD - Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh. FAU - Weber, Ann M AU - Weber AM AUID- ORCID: 0000-0001-8130-5858 AD - Department of Biostatistics, Epidemiology and Environmental Health, University of Nevada Reno School of Public Health, Reno, Nevada, USA. FAU - Dewey, Kathryn G AU - Dewey KG AUID- ORCID: 0000-0002-4185-3451 AD - Institute for Global Nutrition & Department of Nutrition, University of California Davis, Davis, California, USA. LA - eng GR - OPP49817/Bill & Melinda Gates Foundation/ PT - Journal Article DEP - 20260428 PL - England TA - BMJ Glob Health JT - BMJ global health JID - 101685275 RN - 0 (Hemoglobins) SB - IM MH - Humans MH - Infant MH - *Hemoglobins/analysis MH - Child, Preschool MH - Male MH - Female MH - *Anemia/diagnosis/blood/epidemiology MH - *Child Development/physiology MH - Reference Values PMC - PMC13141236 OTO - NOTNLM OT - Anaemia OT - Child health COIS- Competing interests: BFA received travel support (airfare and hotel) covered by the Bill & Melinda Gates Foundation to attend meetings in Seattle during the period of this pooled analysis project; KRW received a grant from Nutriset, SAS outside of the submitted work during the period of this pooled analysis project. All other authors report no conflict of interest. EDAT- 2026/04/29 00:34 MHDA- 2026/04/29 00:35 PMCR- 2026/04/28 CRDT- 2026/04/28 20:53 PHST- 2024/04/08 00:00 [received] PHST- 2026/03/25 00:00 [accepted] PHST- 2026/04/29 00:35 [medline] PHST- 2026/04/29 00:34 [pubmed] PHST- 2026/04/28 20:53 [entrez] PHST- 2026/04/28 00:00 [pmc-release] AID - bmjgh-2024-015866 [pii] AID - 10.1136/bmjgh-2024-015866 [doi] PST - epublish SO - BMJ Glob Health. 2026 Apr 28;11(4):e015866. doi: 10.1136/bmjgh-2024-015866. PMID- 42049310 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 4 DP - 2026 Apr 28 TI - Co-designed web platform (TeenFit) to identify physical activity mobile apps for Spanish adolescents: a study protocol. PG - e114465 LID - 10.1136/bmjopen-2025-114465 [doi] LID - e114465 AB - INTRODUCTION: Adolescence is a critical period marked by physiological and psychological changes that influence long-term health. Establishing healthy behaviours, particularly regular physical activity, is essential during this stage; however, around 80% of young people do not meet the WHO's physical activity recommendations. Digital technologies offer promising opportunities to promote health among youth, yet most physical activity mobile applications (apps) lack scientific validation and usability. Unlike psychology, which has validated repositories to guide users in selecting mental health apps, physical activity lacks validated repository platforms, especially for adolescents. The project has a twofold aim: (1) to co-design a website, named the TeenFit website, that facilitates the selection of physical activity apps tailored to each adolescent's individual needs and preferences and (2) to investigate the barriers and facilitators for the implementation of the TeenFit website in real-world settings. METHODS AND ANALYSIS: Adolescents and other stakeholders (ie, caregivers, educators, and health professionals) will be engaged in the development of the TeenFit website app finder through a participatory design approach that involves three workshops, encompassing both a development phase and an implementation phase. Approximately 10-12 participants per group will take part in smaller working groups to collaboratively contribute to the co-design of the TeenFit website. TeenFit will include physical activity apps available in the Spanish market, developed in both English and Spanish. These applications are currently being identified through two ongoing systematic reviews. In addition to qualitative data gathered during the audio- and video-recorded workshops, quantitative data will be collected on participants' co-design experiences and the acceptability of the TeenFit website. Data analysis will involve descriptive statistics, qualitative content analysis for describing participants' perspectives on what aspects (ie, content, features and layout) are important for the design of the website and reflexive thematic analysis to identify barriers and facilitators to implementation. ETHICS AND DISSEMINATION: The study was approved by the Research Ethics Committee in the province of Malaga (Spain) (REC ref: SICEIA-2024-003172). Research findings will be disseminated primarily via national and international conferences and publication in peer-reviewed journals. Patient and public involvement will inform further dissemination activities. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Seitero, Anna AU - Seitero A AUID- ORCID: 0000-0002-7780-8417 AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden anna.seitero@liu.se. FAU - Ruiz-Moreno, Alicia AU - Ruiz-Moreno A AUID- ORCID: 0009-0009-6360-4817 AD - Department of Languages, Arts and Sports, University of Malaga, Malaga, Spain. FAU - Alcarazo, Adriana AU - Alcarazo A AD - University of Malaga, Malaga, Spain. FAU - Garrido-Gonzalez, Carmen AU - Garrido-Gonzalez C AUID- ORCID: 0000-0003-2074-8131 AD - Nanomedicine Platform (IBIMA Plataforma BIONAND), Malaga Institute of Biomedical Research, Malaga, Spain. AD - Faculty of Psychology, University of Malaga, Malaga, Spain. AD - Research Network on Chronicity, Primary Care, Prevention and Health Promotion (RICAPPS), ISCIII, Malaga, Spain. FAU - Ballesta-Rodriguez, Maria I AU - Ballesta-Rodriguez MI AD - Prevention and Health Promotion Research Network (redIAPP) and Chronicity, Primary Care and Health Promotion Research Network, (RICAPPS), ISCIII, Madrid, Spain. FAU - Henriksson, Pontus AU - Henriksson P AUID- ORCID: 0000-0003-2482-7048 AD - Department of Health, Medicine and Caring Sciences, Linkoping University, Linkoping, Sweden. FAU - Lima, Rodrigo A AU - Lima RA AUID- ORCID: 0000-0002-7778-2616 AD - Impacte i prevencio dels trastorns mentals, Institut de Recerca Sant Joan de Deu (IRSJD), Santa Rosa 39-57, 08950 Esplugues de Llobregat, Spain. AD - Instituto de Salud Carlos III, Centro de Investigacion Biomedica en Red de Salud Mental (CIBERSAM), Madrid, Spain. FAU - Alvarez-Perez, Yolanda AU - Alvarez-Perez Y AUID- ORCID: 0000-0002-6414-2863 AD - Canary Islands Health Research Institute Foundation (FIISC), Tenerife, Spain. AD - Evaluation Unit (SESCS), Canary Islands Health Service (SCS), Tenerife, Spain. AD - Network for Research on Chronicity, Primary Care, and Health Promotion (RICAPPS), Tenerife, Spain. AD - The Spanish Network of Agencies for Health Technology Assessment and Services of the National Health System (RedETS), Tenerife, Spain. AD - Instituto de Investigacion, Sanitaria de Canarias (IISC), Spain. FAU - Reigal, Rafael Enrique AU - Reigal RE AD - Department of Social Psychology, Social Work and Social Services and Social Anthropology, University of Malaga, Malaga, Spain. FAU - Campos Paino, Henar AU - Campos Paino H AUID- ORCID: 0000-0002-0563-3080 AD - University of Malaga, Malaga, Spain. AD - Nanomedicine Platform (IBIMA Plataforma BIONAND), Malaga Institute of Biomedical Research, Malaga, Spain. AD - Prevention and Health Promotion Research Network (redIAPP) and Chronicity, Primary Care and Health Promotion Research Network, (RICAPPS), ISCIII, Madrid, Spain. FAU - Bellon, Juan Angel AU - Bellon JA AUID- ORCID: 0000-0002-4268-4979 AD - Nanomedicine Platform (IBIMA Plataforma BIONAND), Malaga Institute of Biomedical Research, Malaga, Spain. AD - Prevention and Health Promotion Research Network (redIAPP) and Chronicity, Primary Care and Health Promotion Research Network, (RICAPPS), ISCIII, Madrid, Spain. AD - El Palo Health Centre, Andalusian Health Service (SAS), Malaga, Spain. AD - Department of Public Health and Psychiatry, University of Malaga, Malaga, Spain. FAU - Motrico, Emma AU - Motrico E AUID- ORCID: 0000-0002-0720-567X AD - Department of Developmental and Educational Psychology, School of Psychology, University of Seville, Seville, Spain. FAU - Flores-Lopez, Maria AU - Flores-Lopez M AD - Nanomedicine Platform (IBIMA Plataforma BIONAND), Malaga Institute of Biomedical Research, Malaga, Spain. FAU - Rodriguez-Ayllon, Maria AU - Rodriguez-Ayllon M AUID- ORCID: 0000-0002-8267-0440 AD - Department of Languages, Arts and Sports, University of Malaga, Malaga, Spain. AD - Nanomedicine Platform (IBIMA Plataforma BIONAND), Malaga Institute of Biomedical Research, Malaga, Spain. AD - Prevention and Health Promotion Research Network (redIAPP) and Chronicity, Primary Care and Health Promotion Research Network, (RICAPPS), ISCIII, Madrid, Spain. AD - Laboratory of Movement and Body Composition, University of Malaga, Malaga, Spain. LA - eng PT - Journal Article DEP - 20260428 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Adolescent MH - *Mobile Applications MH - *Exercise MH - *Internet MH - Spain MH - *Health Promotion/methods MH - Research Design MH - Female PMC - PMC13141059 OTO - NOTNLM OT - Adolescents OT - Behavior OT - Community-Based Participatory Research OT - Physical Fitness OT - Telemedicine COIS- Competing interests: None declared. EDAT- 2026/04/29 00:34 MHDA- 2026/04/29 00:35 PMCR- 2026/04/28 CRDT- 2026/04/28 20:43 PHST- 2026/04/29 00:35 [medline] PHST- 2026/04/29 00:34 [pubmed] PHST- 2026/04/28 20:43 [entrez] PHST- 2026/04/28 00:00 [pmc-release] AID - bmjopen-2025-114465 [pii] AID - 10.1136/bmjopen-2025-114465 [doi] PST - epublish SO - BMJ Open. 2026 Apr 28;16(4):e114465. doi: 10.1136/bmjopen-2025-114465. PMID- 42049186 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260923 IS - 1543-5474 (Electronic) IS - 1543-3080 (Print) IS - 1543-3080 (Linking) VI - 23 IP - 9 DP - 2026 Sep 1 TI - Feasibility, Acceptability, and Preliminary Impact of an Online Latina Mother-Daughter Physical Activity Intervention. PG - 1250-1259 LID - 10.1123/jpah.2025-0646 [doi] AB - BACKGROUND: Latina girls have low rates of moderate to vigorous physical activity (PA) compared with their male counterparts and non-Hispanic White girls. The current study examines the feasibility, acceptability, and preliminary impact of Conmigo, a mother-daughter PA intervention for preadolescent Latinas (ages 8-11) delivered online. METHODS: Seventy-nine mother-daughter dyads were recruited. Dyads were randomized to a PA intervention or a delayed, abbreviated control condition. The PA intervention consisted of 12 weekly 1.5-hour virtual PA sessions. Feasibility was measured by the delivery, receipt, and enactment of the intervention; acceptability was measured by satisfaction in surveys and interviews in the PA intervention condition. PA and associated secondary outcomes were measured at baseline and follow-up (12 wk) using accelerometry and self-report. RESULTS: Most mothers had some college education (63.3%), and 44.3% worked full time; most daughters were US-born (91.1%) compared with mothers (38.0%). Program fidelity was high (81%-95%) with a mean attendance of 6.2 (SD = 4.6) across 12 sessions. Satisfaction was high (mean = 4.6, SD = 0.8). Qualitative findings indicated that the curriculum met families' needs. No significant changes were observed in daughters' accelerometer-assessed or self-reported PA. A marginal improvement (B = 0.37, P < .05) was found in limit-setting behavior; other parenting outcomes and dyadic effects were nonsignificant. CONCLUSIONS: Qualitative and quantitative findings were not fully aligned regarding feasibility, acceptability, and preliminary impact of the online Conmigo program. Nonetheless, online mother-daughter PA interventions may represent a scalable strategy to have high reach among Latino families. FAU - Arredondo, Elva M AU - Arredondo EM AUID- ORCID: 0000-0002-9715-692X AD - Department of Psychology, San Diego State University, San Diego, CA, USA. AD - Institute for Behavioral and Community Health (IBACH), San Diego State University Foundation, San Diego, CA, USA. FAU - Schneider, Jennifer L AU - Schneider JL AUID- ORCID: 0000-0002-4560-150X AD - Institute for Behavioral and Community Health (IBACH), San Diego State University Foundation, San Diego, CA, USA. FAU - Torres-Ruiz, Marisa S AU - Torres-Ruiz MS AUID- ORCID: 0000-0002-7778-2114 AD - Institute for Behavioral and Community Health (IBACH), San Diego State University Foundation, San Diego, CA, USA. FAU - Telles, Victoria M AU - Telles VM AUID- ORCID: 0000-0001-7220-0181 AD - Institute for Behavioral and Community Health (IBACH), San Diego State University Foundation, San Diego, CA, USA. AD - Joint Doctoral Program in Public Health at San Diego State University-University of California, San Diego, CA, USA. FAU - Butte, Katie AU - Butte K AUID- ORCID: 0000-0002-1253-9586 AD - Department of Health and Human Performance, Seattle Pacific University, Seattle, WA, USA. FAU - Lafuente, Oliva AU - Lafuente O AD - Institute for Behavioral and Community Health (IBACH), San Diego State University Foundation, San Diego, CA, USA. FAU - Formagini, Taynara AU - Formagini T AUID- ORCID: 0000-0001-9318-5734 AD - Institute for Behavioral and Community Health (IBACH), San Diego State University Foundation, San Diego, CA, USA. AD - Department of Family Medicine, University of California San Diego, San Diego, CA, USA. FAU - Cisneroz, Athena AU - Cisneroz A AD - Department of Psychology, San Diego State University, San Diego, CA, USA. FAU - Roesch, Scott C AU - Roesch SC AUID- ORCID: 0000-0001-6574-1916 AD - Department of Psychology, San Diego State University, San Diego, CA, USA. FAU - Baranowski, Tom AU - Baranowski T AUID- ORCID: 0000-0002-0653-2222 AD - Pediatrics-Nutrition, USDA Funded Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX, USA. FAU - Ayala, Guadalupe X AU - Ayala GX AUID- ORCID: 0000-0002-3850-5798 AD - Institute for Behavioral and Community Health (IBACH), San Diego State University Foundation, San Diego, CA, USA. AD - School of Public Health, San Diego State University, San Diego, CA, USA. LA - eng GR - S21 MD010690/MD/NIMHD NIH HHS/United States GR - K24 HL173681/HL/NHLBI NIH HHS/United States GR - 58-6250-0-008/U.S. Department of Agriculture Research Center/ GR - R21 HD100776/HD/NICHD NIH HHS/United States GR - T32 HL079891/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial DEP - 20260428 PL - United States TA - J Phys Act Health JT - Journal of physical activity & health JID - 101189457 SB - IM MH - Humans MH - Female MH - *Hispanic or Latino MH - Feasibility Studies MH - *Exercise MH - Child MH - *Health Promotion/methods MH - *Mothers MH - Adult MH - Accelerometry MH - *Mother-Child Relations MH - *Nuclear Family PMC - PMC13421821 MID - NIHMS2195906 OTO - NOTNLM OT - cultural adaptation OT - dyadic analysis OT - family-based health promotion OT - health equity OT - parenting practices EDAT- 2026/04/29 00:34 MHDA- 2026/08/27 04:07 PMCR- 2026/07/31 CRDT- 2026/04/28 19:33 PHST- 2025/09/01 00:00 [received] PHST- 2026/03/06 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/08/27 04:07 [medline] PHST- 2026/04/29 00:34 [pubmed] PHST- 2026/04/28 19:33 [entrez] PHST- 2026/07/31 00:00 [pmc-release] AID - 10.1123/jpah.2025-0646 [doi] PST - epublish SO - J Phys Act Health. 2026 Apr 28;23(9):1250-1259. doi: 10.1123/jpah.2025-0646. Print 2026 Sep 1. PMID- 42048665 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260617 IS - 2191-0251 (Electronic) IS - 0334-018X (Linking) VI - 39 IP - 6 DP - 2026 Jun 24 TI - Predicting abdominal obesity in children and adolescents via machine learning: a longitudinal cohort study. PG - 545-555 LID - 10.1515/jpem-2025-0321 [doi] AB - OBJECTIVES: This study aimed to construct and verify machine learning (ML) models to predict long-term abdominal obesity (AO) risk in children and adolescents. METHODS: We trained and externally validated ML models to predict pediatric AO 4-5 years later using a publicly available longitudinal cohort. The body roundness index (BRI) was used as the diagnostic criterion for AO. The training/internal-validation cohort comprised 635 youths (2011-->2015); an independent 2006-->2011 cohort (n=456) provided external validation. After screening 25 routine variables and multiple imputation, four ML algorithms were evaluated by area under the receiver operating characteristic curve (AUC), sensitivity, specificity and F1-score across all three datasets. RESULTS: Among 635 children and adolescents in the raw-training set followed for four years, 164 (25.83 %) developed AO. Univariable analysis identified 12 significant baseline predictors (p<0.1); multivariable logistic regression (LR) retained five independent factors: body mass index (BMI), height, carbohydrate intake, reading/writing activity and urban residence. Four machine-learning algorithms were trained and validated; LR demonstrated the most stable performance across training (AUC=0.705), internal validation (AUC=0.742) and external validation (AUC=0.667) datasets. CONCLUSIONS: The LR model stands out as a potential tool in predicting long-term AO risk in children and adolescents. CI - (c) 2026 Walter de Gruyter GmbH, Berlin/Boston. FAU - Ding, Xiaoyan AU - Ding X AD - Pediatric Department, Beijing Anzhen Nanchong Hospital, Capital Medical University & Nanchong Central Hospital, Nanchong, China. FAU - Fang, Xiao AU - Fang X AUID- ORCID: 0009-0005-7358-1349 AD - 85407 National Science Library (Chengdu), Chinese Academy of Sciences , Chengdu, China. FAU - Bai, Jing AU - Bai J AD - Pediatric Department, Beijing Anzhen Nanchong Hospital, Capital Medical University & Nanchong Central Hospital, Nanchong, China. FAU - Liu, Rui AU - Liu R AD - Pediatric Department, Beijing Anzhen Nanchong Hospital, Capital Medical University & Nanchong Central Hospital, Nanchong, China. FAU - Ma, Can AU - Ma C AD - School of Public Health, Suzhou Medical College of Soochow University, Suzhou, China. LA - eng PT - Journal Article DEP - 20260427 PL - Germany TA - J Pediatr Endocrinol Metab JT - Journal of pediatric endocrinology & metabolism : JPEM JID - 9508900 SB - IM MH - Humans MH - Child MH - Adolescent MH - *Obesity, Abdominal/diagnosis/epidemiology MH - *Machine Learning MH - Female MH - Longitudinal Studies MH - Male MH - *Body Mass Index MH - Predictive Learning Models MH - Prognosis MH - Prediction Algorithms MH - Follow-Up Studies MH - Risk Factors MH - Classification Algorithms MH - ROC Curve MH - *Pediatric Obesity/diagnosis/epidemiology MH - Algorithms OTO - NOTNLM OT - abdominal obesity OT - adolescent OT - child OT - logistic models OT - machine learning EDAT- 2026/04/28 18:33 MHDA- 2026/06/13 00:38 CRDT- 2026/04/28 17:13 PHST- 2025/06/06 00:00 [received] PHST- 2026/03/12 00:00 [accepted] PHST- 2026/06/13 00:38 [medline] PHST- 2026/04/28 18:33 [pubmed] PHST- 2026/04/28 17:13 [entrez] AID - jpem-2025-0321 [pii] AID - 10.1515/jpem-2025-0321 [doi] PST - epublish SO - J Pediatr Endocrinol Metab. 2026 Apr 27;39(6):545-555. doi: 10.1515/jpem-2025-0321. Print 2026 Jun 24. PMID- 42048577 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 1613-9860 (Electronic) IS - 1613-9860 (Linking) VI - 16 IP - 1 DP - 2026 Jan 7 TI - Using EPIS and facilitation to support delivery of classroom-based physical activity interventions: a case study. LID - ibag005 [pii] LID - 10.1093/tbm/ibag005 [doi] AB - BACKGROUND: Youth physical inactivity is a major public health concern, particularly in schools serving socioeconomically disadvantaged children. Classroom-based physical activity (PA) interventions offer structured, equitable opportunities for movement, but adoption-fidelity gaps persist. Implementation science frameworks can support schools in aligning interventions with local context and sustaining delivery. PURPOSE: This study examined the feasibility of using the Exploration, Preparation, Implementation, and Sustainment (EPIS) framework, paired with facilitation by trained regional school health coordinators, to guide classroom PA implementation in a Michigan elementary school. METHODS: An EPIS-aligned implementation guide was developed and refined through a two-phase process to ensure theoretical grounding and practical applicability. Six coordinators were trained and evaluated the training using validated measures of acceptability, appropriateness, and feasibility. One coordinator facilitated InPACT implementation at a single school over 18 months, supporting pre-implementation, rollout, and early sustainment. Implementation was documented using the Hexagon Tool, RE-AIM, Plan-Do-Study-Act cycles, and routine administrative data. RESULTS: Coordinators rated the training highly on all measures. In the pilot school, teachers delivered an average of three PA breaks per day, with lower-elementary classrooms averaging four and upper-elementary classrooms averaging two. Fidelity was supported through structured ramp-up, teacher training, technical assistance, and classroom tracking. Integration into school systems helped to fill gaps in the school district wellness policy. Behavioral referral data indicated a 34% reduction in minor classroom incidents over the first year of implementation. CONCLUSIONS: EPIS-guided implementation with facilitation is feasible for supporting adoption, fidelity, and early sustainment of classroom PA. Structured pre-implementation planning, phase-specific support, and alignment with school priorities are critical. Multi-site studies are needed to examine grade-specific strategies, fidelity variability, and long-term sustainment. CI - (c) Society of Behavioral Medicine 2026. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Hasson, Rebecca E AU - Hasson RE AUID- ORCID: 0000-0003-4526-2656 AD - University of Michigan School of Kinesiology, Ann Arbor, MI, United States. FAU - Dros, Danielle AU - Dros D AD - Washtenaw Intermediate School District, Ann Arbor, MI, United States. FAU - Roy-Borland, Heidi AU - Roy-Borland H AD - Whitmore Lake Elementary School, Whitmore Lake, MI, United States. FAU - Eisman, Andria B AU - Eisman AB AD - Center for Health and Community Impact, Wayne State University College of Education, Detroit, MI, United States. FAU - Friday, Penelope J AU - Friday PJ AD - University of Michigan School of Kinesiology, Ann Arbor, MI, United States. FAU - Schwartz, Anna AU - Schwartz A AD - University of Michigan School of Kinesiology, Ann Arbor, MI, United States. FAU - Abbas, Hala I AU - Abbas HI AD - University of Michigan School of Kinesiology, Ann Arbor, MI, United States. LA - eng GR - R-2204-150254/Michigan Health Endowment Fund/ PT - Journal Article PL - England TA - Transl Behav Med JT - Translational behavioral medicine JID - 101554668 SB - IM MH - Humans MH - Schools MH - *Exercise MH - *Health Promotion/methods MH - Child MH - *School Health Services MH - Implementation Science MH - Michigan MH - Feasibility Studies OAB - Many children do not get enough physical activity (PA) during school, especially in under-resourced settings. This inactivity can negatively affect physical, emotional, and cognitive development. We tested whether the EPIS framework-Exploration, Preparation, Implementation, and Sustainment-combined with facilitation provided by trained regional school health coordinators, could help schools adopt and maintain InPACT (Interrupting Prolonged Sitting with Activity), a classroom-based PA intervention. Facilitation means hands-on support for teachers and leaders, including strategic thinking and problem-solving, and guidance on using EPIS-aligned tools. InPACT encourages teachers to provide short activity breaks throughout the school day. Six coordinators were trained to use the guide combining EPIS with facilitation. One elementary school piloted the approach for over 18 months. Teachers delivered an average of three activity breaks daily, with younger grades averaging more than older ones. Teachers and administrators also reported improved student behavior, and the school embedded activity breaks into staff onboarding to ensure long-term use. Our findings show that EPIS with facilitation can help schools plan, deliver, monitor, and sustain classroom activity breaks. Larger studies are needed to strengthen evidence and support wider adoption. OABL- eng OTO - NOTNLM OT - exercise OT - health promotion OT - implementation science OT - program sustainability OT - schools EDAT- 2026/04/28 18:33 MHDA- 2026/04/28 18:34 CRDT- 2026/04/28 15:13 PHST- 2025/09/14 00:00 [received] PHST- 2025/12/29 00:00 [revised] PHST- 2026/01/22 00:00 [accepted] PHST- 2026/04/28 18:34 [medline] PHST- 2026/04/28 18:33 [pubmed] PHST- 2026/04/28 15:13 [entrez] AID - 8664265 [pii] AID - 10.1093/tbm/ibag005 [doi] PST - ppublish SO - Transl Behav Med. 2026 Jan 7;16(1):ibag005. doi: 10.1093/tbm/ibag005. PMID- 42048259 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260901 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Apr 28 TI - A Formative Evaluation of Parental Perceptions Related to Acceptability, Appropriateness, Feasibility, and Reported Use of an e-Learning Resource Targeting Diet in the First 1000 Days: Survey Study. PG - e84277 LID - 10.2196/84277 [doi] LID - e84277 AB - BACKGROUND: In October 2022, the Nutrition Now (NN) e-learning resource was implemented within Maternal and Child Healthcare centers and Early Childhood Education and Care centers of a southern Norwegian municipality. The e-learning resource targets expectant parents, parents of children aged 0-2 years, and Early Childhood Education and Care staff, aiming to promote healthy dietary behaviors during the first 1000 days of life. OBJECTIVE: This study aimed to explore parental perceptions related to the acceptability, appropriateness, feasibility, and reported use of the NN e-learning resource among parents. METHODS: From October 2022 to May 2023, expecting parents and parents of children aged 0-2 years were recruited from 2 Norwegian municipalities, one intervention group receiving access to the NN e-learning resource, and one control. Participants in the intervention group received a web-based follow-up questionnaire 7 months after gaining access to the NN e-learning resource. Data were analyzed using descriptive statistics. RESULTS: Of the 179 participants in the NN study intervention group, 48 completed the web-based follow-up questionnaire administered 7 months after enrollment. Parents rated the e-learning resource positively on items assessing whether they liked and appreciated the resource, perceived it as an appropriate source of information, and found it doable and easy to use. Most respondents reported visiting the resource (38/48, 79%), although only 21% (10/48) reported frequent visits. Less than half of the participants answering the web-based follow-up questionnaire reported having watched the theme films (20/48, 42%), the recipe films (17/48, 35%), or making food using recipes provided in the e-learning resource (20/48, 42%). CONCLUSIONS: Parents rated the NN e-learning resource positively but reported limited use. These findings point to the need for strategies that enhance engagement with self-guided digital interventions among expectant parents and parents of young children. Future efforts should focus on identifying how to maximize potential adoption of the e-learning resource and evaluate its impact to promote healthy dietary behaviors during the first 1000 days of life. CI - (c) Natalie Garzon Osorio, Froydis Nordgard Vik, Elisabet Rudjord Hillesund, Sissel Heidi Helland, Penelope Love, Marianne Hope Abel, Harry Rutter, Andrew Keith Wills, Christine Helle, Tormod Bjorkkjaer, Nina Cecilie Overby, Anine Christine Medin. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Osorio, Natalie Garzon AU - Osorio NG AUID- ORCID: 0009-0007-3064-3137 AD - Department of Nutrition and Public Health, Faculty of Health and Sport Sciences, University of Agder, Universitetsveien 25, Kristiansand, 4630, Norway, +4799570261. FAU - Vik, Froydis Nordgard AU - Vik FN AUID- ORCID: 0000-0001-7324-0070 AD - Department of Nutrition and Public Health, Faculty of Health and Sport Sciences, University of Agder, Universitetsveien 25, Kristiansand, 4630, Norway, +4799570261. FAU - Hillesund, Elisabet Rudjord AU - Hillesund ER AUID- ORCID: 0000-0003-0757-1861 AD - Department of Nutrition and Public Health, Faculty of Health and Sport Sciences, University of Agder, Universitetsveien 25, Kristiansand, 4630, Norway, +4799570261. FAU - Helland, Sissel Heidi AU - Helland SH AUID- ORCID: 0000-0002-7141-5524 AD - Department of Nutrition and Public Health, Faculty of Health and Sport Sciences, University of Agder, Universitetsveien 25, Kristiansand, 4630, Norway, +4799570261. FAU - Love, Penelope AU - Love P AUID- ORCID: 0000-0002-1244-3947 AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, Australia. FAU - Abel, Marianne Hope AU - Abel MH AUID- ORCID: 0000-0001-6519-2064 AD - Centre for Evaluation of Public Health Measures, Norwegian Institute of Public Health, Oslo, Norway. FAU - Rutter, Harry AU - Rutter H AUID- ORCID: 0000-0002-9322-0656 AD - Department of Nutrition and Public Health, Faculty of Health and Sport Sciences, University of Agder, Universitetsveien 25, Kristiansand, 4630, Norway, +4799570261. AD - Centre for 21st Century Public Health, University of Bath, Bath, United Kingdom. FAU - Wills, Andrew Keith AU - Wills AK AUID- ORCID: 0000-0002-9751-4707 AD - Department of Nutrition and Public Health, Faculty of Health and Sport Sciences, University of Agder, Universitetsveien 25, Kristiansand, 4630, Norway, +4799570261. FAU - Helle, Christine AU - Helle C AUID- ORCID: 0000-0002-2113-9218 AD - Department of Nutrition and Public Health, Faculty of Health and Sport Sciences, University of Agder, Universitetsveien 25, Kristiansand, 4630, Norway, +4799570261. FAU - Bjorkkjaer, Tormod AU - Bjorkkjaer T AUID- ORCID: 0000-0003-2337-055X AD - Department of Nutrition and Public Health, Faculty of Health and Sport Sciences, University of Agder, Universitetsveien 25, Kristiansand, 4630, Norway, +4799570261. FAU - Overby, Nina Cecilie AU - Overby NC AUID- ORCID: 0000-0002-1871-041X AD - Department of Nutrition and Public Health, Faculty of Health and Sport Sciences, University of Agder, Universitetsveien 25, Kristiansand, 4630, Norway, +4799570261. FAU - Medin, Anine Christine AU - Medin AC AUID- ORCID: 0000-0003-4154-6264 AD - Department of Nutrition and Public Health, Faculty of Health and Sport Sciences, University of Agder, Universitetsveien 25, Kristiansand, 4630, Norway, +4799570261. LA - eng SI - ISRCTN/ISRCTN10694967 PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260428 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Female MH - *Parents/psychology/education MH - Male MH - Surveys and Questionnaires MH - Norway MH - Adult MH - Infant MH - Feasibility Studies MH - Child, Preschool MH - *Perception MH - *Diet MH - Infant, Newborn PMC - PMC13123635 OTO - NOTNLM OT - AIM OT - Acceptability of Intervention Measure OT - FIM OT - Feasibility of Intervention Measure OT - IAM OT - Intervention Appropriateness Measure OT - diet intervention OT - digital health OT - digital intervention OT - e-learning resource OT - first 1000 days COIS- Conflicts of Interest: None declared. EDAT- 2026/04/28 18:33 MHDA- 2026/04/28 18:34 PMCR- 2026/04/28 CRDT- 2026/04/28 13:12 PHST- 2025/09/17 00:00 [received] PHST- 2026/03/17 00:00 [revised] PHST- 2026/03/18 00:00 [accepted] PHST- 2026/04/28 18:34 [medline] PHST- 2026/04/28 18:33 [pubmed] PHST- 2026/04/28 13:12 [entrez] PHST- 2026/04/28 00:00 [pmc-release] AID - v10i1e84277 [pii] AID - 84277 [pii] AID - 10.2196/84277 [doi] PST - epublish SO - JMIR Form Res. 2026 Apr 28;10:e84277. doi: 10.2196/84277. PMID- 42047932 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260921 IS - 1573-0972 (Electronic) IS - 0959-3993 (Print) IS - 0959-3993 (Linking) VI - 42 IP - 5 DP - 2026 Apr 28 TI - Species sorting shapes the divergence of a traditional fermented dairy-derived bacterial community with repeatable functionality during propagation with alternative substrates. LID - 10.1007/s11274-026-04830-3 [doi] LID - 243 AB - Species sorting underlies changes in microbial community composition under varying environments, yet predicting the species diversity and their functional outcomes when exposed to novel conditions remains challenging. We explored this using mabisi, a Zambian traditional fermented milk, by propagating a shared starting mabisi microbial community across five novel substrates - raw bovine milk (control), low-fat milk, full-cream milk, and the infant formulas F100 and S26 - under static conditions and fixed dilution for ~ 33 generations, at three rural farm sites. The microbial community composition was profiled through 16 S rDNA sequencing, and community-level functioning through volatile organic compounds, pH, and consistency. We observed a substrate-driven divergence of microbial communities, with low-fat milk enriched with Acetobacter, full-cream milk enriched with Lactococcus, and S26 enriched with Lactiplantibacillus and Leuconostoc. This pattern exhibited a temporal community succession but remained consistent between sites. Similarly, the community-level functionality diverged but remained largely repeatable to properties known for mabisi. Our findings suggest that novel environments drive a species sorting process in natural microbial communities, and this process persists over time. Additionally, the repeatability of its community-level functionality points to underlying functional redundancy within diverse and successive microbial communities. Our study not only advances the understanding of how microbial communities adapt to environmental changes but also provides a basis for harnessing the mabisi-derived microbial community for broad biotechnological applications, particularly supporting the feasibility and effectiveness of its use in an in-house formulated F100 infant formula for treating malnourished children in developing regions. FAU - Nehanda, Shepherd AU - Nehanda S AUID- ORCID: 0009-0005-4297-8829 AD - Department of Biomedical Sciences, National Health Research and Training Institute (Formerly Tropical Diseases Research Centre), Ndola, Zambia. nehandas@tdrc.org.zm. AD - Laboratory of Genetics and Laboratory of Food Microbiology, Wageningen University and Research, Wageningen, The Netherlands. nehandas@tdrc.org.zm. FAU - Alekseeva, Anna Y AU - Alekseeva AY AUID- ORCID: 0000-0003-0164-0539 AD - Laboratory of Genetics and Laboratory of Food Microbiology, Wageningen University and Research, Wageningen, The Netherlands. FAU - van Mastrigt, Oscar AU - van Mastrigt O AUID- ORCID: 0000-0001-6576-910X AD - Laboratory of Genetics and Laboratory of Food Microbiology, Wageningen University and Research, Wageningen, The Netherlands. FAU - Chileshe, Justin AU - Chileshe J AUID- ORCID: 0000-0003-4134-2851 AD - Department of Biomedical Sciences, National Health Research and Training Institute (Formerly Tropical Diseases Research Centre), Ndola, Zambia. FAU - Zwaan, Bas J AU - Zwaan BJ AUID- ORCID: 0000-0002-8221-4998 AD - Laboratory of Genetics and Laboratory of Food Microbiology, Wageningen University and Research, Wageningen, The Netherlands. FAU - Smid, Eddy J AU - Smid EJ AUID- ORCID: 0000-0002-6687-5083 AD - Laboratory of Genetics and Laboratory of Food Microbiology, Wageningen University and Research, Wageningen, The Netherlands. FAU - Schoustra, Sijmen E AU - Schoustra SE AUID- ORCID: 0000-0001-7843-5539 AD - Laboratory of Genetics and Laboratory of Food Microbiology, Wageningen University and Research, Wageningen, The Netherlands. sijmen.schoustra@wur.nl. AD - Department of Food Science and Nutrition, The University of Zambia, Lusaka, Zambia. sijmen.schoustra@wur.nl. LA - eng PT - Journal Article DEP - 20260428 PL - Germany TA - World J Microbiol Biotechnol JT - World journal of microbiology & biotechnology JID - 9012472 RN - 0 (RNA, Ribosomal, 16S) RN - 0 (Volatile Organic Compounds) RN - 0 (DNA, Bacterial) SB - IM MH - Animals MH - Fermentation MH - *Cultured Milk Products/microbiology MH - *Milk/microbiology MH - Cattle MH - *Bacteria/classification/genetics/isolation & purification/metabolism MH - RNA, Ribosomal, 16S/genetics MH - *Microbiota MH - Hydrogen-Ion Concentration MH - Infant Formula/microbiology MH - Volatile Organic Compounds/analysis MH - Lactococcus MH - Biodiversity MH - Food Microbiology MH - DNA, Bacterial/genetics MH - Acetobacter/isolation & purification MH - Phylogeny PMC - PMC13124831 OTO - NOTNLM OT - Adaptation OT - Diversity OT - Infant formula OT - Lactic acid bacteria OT - Natural microbial community OT - Selection COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/04/28 17:38 MHDA- 2026/06/28 13:04 PMCR- 2026/04/28 CRDT- 2026/04/28 11:20 PHST- 2025/10/02 00:00 [received] PHST- 2026/01/29 00:00 [accepted] PHST- 2026/06/28 13:04 [medline] PHST- 2026/04/28 17:38 [pubmed] PHST- 2026/04/28 11:20 [entrez] PHST- 2026/04/28 00:00 [pmc-release] AID - 10.1007/s11274-026-04830-3 [pii] AID - 4830 [pii] AID - 10.1007/s11274-026-04830-3 [doi] PST - epublish SO - World J Microbiol Biotechnol. 2026 Apr 28;42(5):243. doi: 10.1007/s11274-026-04830-3. PMID- 42047227 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2047-7163 (Electronic) IS - 0036-8504 (Print) IS - 0036-8504 (Linking) VI - 109 IP - 2 DP - 2026 Apr-Jun TI - Does three-dimensional facial morphology relate to risk of sleep-disordered breathing in children? A cross-sectional study. PG - 368504261446472 LID - 10.1177/00368504261446472 [doi] LID - 00368504261446472 AB - ObjectiveTo assess the feasibility of three-dimensional (3D) stereophotogrammetry as a tool in pediatric outpatient assessment, in exploring associations between facial morphometric parameters of children aged 2-17 years, and their risk of sleep-disordered breathing (SDB) as evidenced by their Pediatric Sleep Questionnaire (PSQ) score.MethodsA cross-sectional study of 180 pediatric patients (aged 2-17 years) recruited consecutively from a tertiary pediatric otolaryngology clinic. 3D facial images were acquired using stereophotogrammetry, and patients' SDB risk was evaluated using the validated PSQ. Linear regression models assessed associations between PSQ scores and demographic and facial morphometric variables. Geometric morphometric (GMM) analysis was performed to assess differences in facial morphology between subjects at high and low risk for SDB.Results33.9% of patients scored at high risk for SDB. No statistically significant associations were found between PSQ score and any 3D facial morphometric parameter. PSQ score was not associated with sex, age, agexsex interaction, or body mass index. Geometric morphometric analysis found no difference in facial shape between those at high risk for SDB and those at lower risk.ConclusionsStereophotogrammetry may be successfully applied in a specialist pediatric outpatient clinic as a non-invasive and low-resource method for measuring 3D facial features. No linear or angular measurements assessed in this study were found to have a strong correlation with PSQ score. These findings suggest that 3D external facial soft-tissue measures may not add discriminatory value beyond symptom-based screening in this tertiary clinic setting, and that facial morphology alone is unlikely to be a sufficient screening tool for pediatric SDB. Screening should primarily be based on patient signs and symptoms, and consideration of internal anatomical factors. FAU - Pliska, Benjamin T AU - Pliska BT AUID- ORCID: 0000-0002-8935-7203 AD - Division of Orthodontics, Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada. RINGGOLD: 8166 FAU - Wu, Felix Y H AU - Wu FYH AD - Division of Orthodontics, Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada. RINGGOLD: 8166 FAU - Liu, Alice Q AU - Liu AQ AD - Division of Pediatric Otolaryngology-Head & Neck Surgery, BC Children's Hospital, Vancouver, BC, Canada. FAU - Vora, Siddharth R AU - Vora SR AD - Division of Orthodontics, Department of Oral Health Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada. RINGGOLD: 8166 FAU - Chadha, Neil K AU - Chadha NK AD - Division of Pediatric Otolaryngology-Head & Neck Surgery, BC Children's Hospital, Vancouver, BC, Canada. LA - eng PT - Journal Article DEP - 20260428 PL - England TA - Sci Prog JT - Science progress JID - 0411361 SB - IM MH - Humans MH - Child MH - Cross-Sectional Studies MH - Female MH - Male MH - Child, Preschool MH - Adolescent MH - *Sleep Apnea Syndromes/diagnosis/pathology MH - *Face/anatomy & histology MH - Photogrammetry/methods MH - *Imaging, Three-Dimensional MH - Risk Factors MH - Surveys and Questionnaires PMC - PMC13145041 OTO - NOTNLM OT - craniofacial morphology OT - geometric morphometrics OT - obstructive sleep apnea OT - pediatrics OT - sleep-disordered breathing OT - snoring OT - stereophotogrammetry COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/04/28 17:38 MHDA- 2026/04/28 17:39 PMCR- 2026/04/28 CRDT- 2026/04/28 06:23 PHST- 2026/04/28 17:39 [medline] PHST- 2026/04/28 17:38 [pubmed] PHST- 2026/04/28 06:23 [entrez] PHST- 2026/04/28 00:00 [pmc-release] AID - 10.1177_00368504261446472 [pii] AID - 10.1177/00368504261446472 [doi] PST - ppublish SO - Sci Prog. 2026 Apr-Jun;109(2):368504261446472. doi: 10.1177/00368504261446472. Epub 2026 Apr 28. PMID- 42047137 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260818 IS - 1972-6007 (Electronic) IS - 0009-9074 (Linking) VI - 177 IP - 3 DP - 2026 May-Jun TI - Geriatric Nutritional Risk Index as a Predictor of Sarcopenia in Egyptian Patients with Viral Hepatitis-Related Liver Cirrhosis. PG - 502-516 LID - 10.7417/CT.2026.2035 [doi] AB - BACKGROUND: Sarcopenia is a prevalent yet underdiagnosed complication in elderly patients with liver cirrhosis, associated with poor outcomes and increased frailty. In low-resource settings, the use of advanced imaging techniques for sarcopenia assessment is often limited. The Geriatric Nutritional Risk Index (GNRI) is a simple tool that may serve as a surrogate marker for sarcopenia, particularly in high-risk populations such as elderly cirrhotic patients with viral hepatitis. OBJECTIVE: To evaluate the clinical utility of the GNRI in predicting sarcopenia and its severity in elderly Egyptian patients with viral hepatitis-related liver cirrhosis, and to explore its correlations with liver function scores and physical performance indices. METHODS: This cross-sectional study included 90 elderly patients (aged >/= 60 years) with viral hepatitis-related cirrhosis. Sarcopenia was diagnosed and staged according to EWGSOP2 criteria, incorporating measurements of muscle strength (handgrip), muscle mass (calf circumference), and physical performance (gait speed, KATZ index). GNRI was calculated using serum albumin and body weight. Liver disease severity was assessed using Child-Pugh and ALBI scores. Correlations between GNRI, sarcopenia components, and liver scores were analyzed, and diagnostic accuracy of GNRI and Child score in predicting severe sarcopenia was evaluated. RESULTS: The prevalence of sarcopenia in the cohort was 95.5%, with 42.2% classified as having severe sarcopenia. GNRI showed significant positive correlations with muscle strength (r = 0.536, p < 0.001), gait speed (r = 0.377, p = 0.001), and negative correlations with Child score (r = -0.240, p = 0.023) and ALBI score (r = -0.380, p < 0.001). A GNRI /= 34 weeks (n = 29) based on the gestational age at diagnosis. Baseline characteristics, management strategies, and perinatal outcomes were compared among the three groups. RESULTS: The utilization rate of low molecular weight heparin (LMWH) in the group of < 28 weeks was significantly higher than that of >/= 34 weeks (87.50% vs. 13.79%, p < 0.001). Compared to the >/= 34-week group, the groups of < 28 weeks and 28-33(+)(6) weeks demonstrated a higher rate of expectant management, an earlier gestational age at delivery, and a longer time of pregnancy prolongation (all p < 0.05). Neonatal birth weight increased with increasing gestational age at UAT diagnosis, in which the group of >/= 34 weeks had higher birth weight than those of < 28 weeks (p = 0.031) and 28-33(+)(6) weeks (p = 0.003). Neonates in the earlier gestational age groups required significantly longer neonatal intensive care unit (NICU) stays (all p < 0.001). Notably, in the group of < 34 weeks, expectant management showed a higher delivery gestational age (p = 0.020) and a lower NICU admission rate (p = 0.024) than emergency cesarean delivery, while in the >/= 34-week group no statistically significant differences were observed. CONCLUSIONS: In this retrospective study, expectant management was associated with higher delivery gestational age and lower NICU admission rate than emergency cesarean delivery for UAT diagnosed before 34 weeks, whereas no significant differences between the two strategies were observed for diagnoses at or after 34 weeks. These hypothesis-generating findings require validation in prospective, multicenter studies. FAU - Wang, Lin AU - Wang L AD - Department of Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, Zhejiang, China. FAU - Zou, Yuqing AU - Zou Y AD - Department of Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, Zhejiang, China. FAU - Jing, Xiaolin AU - Jing X AD - Department of Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, Zhejiang, China. FAU - Zhou, Ying AU - Zhou Y AD - Department of Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, Zhejiang, China. FAU - Han, Xiujun AU - Han X AD - Department of Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, Zhejiang, China. FAU - Hu, Ying AU - Hu Y AD - Department of Obstetrics, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006, Zhejiang, China. 5309001@zju.edu.cn. FAU - Xu, Jian AU - Xu J AD - Department of Assisted Reproduction, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, 310006, China. xuj@zju.edu.cn. LA - eng PT - Journal Article DEP - 20260427 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - 0 (Heparin, Low-Molecular-Weight) RN - 0 (Anticoagulants) SB - IM MH - Humans MH - Female MH - Pregnancy MH - Retrospective Studies MH - *Gestational Age MH - *Cesarean Section/statistics & numerical data MH - *Umbilical Arteries MH - *Thrombosis/therapy/drug therapy MH - China MH - *Heparin, Low-Molecular-Weight/therapeutic use MH - Adult MH - Infant, Newborn MH - Tertiary Care Centers MH - Pregnancy Outcome MH - Anticoagulants/therapeutic use MH - *Watchful Waiting MH - Birth Weight MH - *Pregnancy Complications, Cardiovascular/therapy PMC - PMC13255401 OTO - NOTNLM OT - Gestational age OT - Low molecular weight heparin OT - Management strategy OT - Perinatal outcomes OT - Umbilical artery thrombosis COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethics Committee of Women's Hospital, Zhejiang University School of Medicine (approval number: IRB-20250114-R), and was performed in accordance with Declaration of Helsinki. The patients provided written informed consent. Written informed consent was obtained from all participants at the time of hospital admission as part of the institutional consent process for obstetric care. This standardized form includes a section permitting the use of de-identified clinical data for retrospective research. All patients included in this study signed this form. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/28 00:33 MHDA- 2026/06/27 18:39 PMCR- 2026/04/27 CRDT- 2026/04/27 23:55 PHST- 2025/10/22 00:00 [received] PHST- 2026/04/23 00:00 [accepted] PHST- 2026/06/27 18:39 [medline] PHST- 2026/04/28 00:33 [pubmed] PHST- 2026/04/27 23:55 [entrez] PHST- 2026/04/27 00:00 [pmc-release] AID - 10.1186/s12884-026-09165-3 [pii] AID - 9165 [pii] AID - 10.1186/s12884-026-09165-3 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Apr 27;26(1):638. doi: 10.1186/s12884-026-09165-3. PMID- 42044871 OWN - NLM STAT- MEDLINE DCOM- 20260610 LR - 20260610 IS - 2191-0251 (Electronic) IS - 0334-018X (Linking) VI - 39 IP - 5 DP - 2026 May 26 TI - Puberty promoting low dose testosterone treatment improved wellbeing and emotional state in boys with self-limited delayed puberty. PG - 425-431 LID - 10.1515/jpem-2025-0719 [doi] AB - OBJECTIVES: To evaluate changes in health-related quality of life in boys aged 14-16 years with delayed or slowly progressing puberty before and after low-dose testosterone treatment. Delayed puberty can cause short stature, emotional distress, and social challenges. Testosterone therapy promotes growth and masculinization, but its impact on quality of life remains poorly understood. Few studies have assessed psychosocial outcomes using validated instruments. METHODS: Twenty-seven boys enrolled in the Pubertal Replacement in Boys Study and were randomized to testosterone enanthate (75 mg/month for 6 months; n=12) (n=12) or testosterone undecanoate (n=12) (250 mg every 3 months; n=15). Standardized self-report questionnaires assessed generic quality of life (primary outcome), stature-specific quality of life, depressive symptoms, and enjoyment of physical activity. Assessments were conducted at baseline, 6 months, and 12 months. RESULTS: Twenty-six boys completed the study. Both regimens induced pubertal progression and a mean growth of 9.3 cm 12 months after start of replacement treatment. Significant improvements were observed in generic quality of life and depressive symptoms, with early gains sustained through 12 months. No changes were detected in stature-specific quality of life or enjoyment of physical activity. No statistical differences were found between treatment groups at 6 or 12 months. Exploratory analyses suggested that baseline testosterone serum levels were modestly associated with changes in social functioning, whereas later serum levels showed no such relationship. CONCLUSIONS: Low-dose testosterone therapy improves generic quality of life and mood in boys with self-limited delayed puberty, likely reflecting successful pubertal progression. These findings highlight the importance of psychosocial outcomes as indicators of treatment success, beyond growth acceleration, and support structured follow-up to address the emotional needs of adolescents with delayed puberty. CI - (c) 2026 the author(s), published by De Gruyter, Berlin/Boston. FAU - Osterbrand, Martin AU - Osterbrand M AUID- ORCID: 0000-0003-4684-1983 AD - Department of Paediatrics, Gothenburg Paediatric Growth Research Centre, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. AD - Nal Uddevalla Sjukvarden (NU) Hospital Group, Trollhattan, Sweden. FAU - Fors, Hans AU - Fors H AUID- ORCID: 0009-0006-2252-8545 AD - Department of Paediatrics, Gothenburg Paediatric Growth Research Centre, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. AD - Gothenburg Department of Paediatrics, Endocrine Division, Queen Silvia Children's Hospital, Gothenburg, Sweden. FAU - Norjavaara, Ensio AU - Norjavaara E AUID- ORCID: 0000-0003-0415-4843 AD - Department of Paediatrics, Gothenburg Paediatric Growth Research Centre, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. AD - Gothenburg Department of Paediatrics, Endocrine Division, Queen Silvia Children's Hospital, Gothenburg, Sweden. FAU - Chaplin, John Eric AU - Chaplin JE AUID- ORCID: 0000-0001-8128-4225 AD - Department of Paediatrics, Gothenburg Paediatric Growth Research Centre, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260424 PL - Germany TA - J Pediatr Endocrinol Metab JT - Journal of pediatric endocrinology & metabolism : JPEM JID - 9508900 RN - 3XMK78S47O (Testosterone) RN - 7Z6522T8N9 (testosterone enanthate) RN - H16A5VCT9C (testosterone undecanoate) RN - 0 (Androgens) SB - IM MH - Humans MH - Male MH - Adolescent MH - *Puberty, Delayed/drug therapy/psychology MH - *Testosterone/analogs & derivatives/administration & dosage/therapeutic use MH - *Quality of Life MH - *Emotions/drug effects MH - *Puberty/drug effects MH - Follow-Up Studies MH - Prognosis MH - *Androgens/administration & dosage MH - *Hormone Replacement Therapy OTO - NOTNLM OT - Kidscreen OT - delayed puberty OT - quality of life OT - testosterone EDAT- 2026/04/28 00:33 MHDA- 2026/06/10 11:43 CRDT- 2026/04/27 19:14 PHST- 2025/12/17 00:00 [received] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/06/10 11:43 [medline] PHST- 2026/04/28 00:33 [pubmed] PHST- 2026/04/27 19:14 [entrez] AID - jpem-2025-0719 [pii] AID - 10.1515/jpem-2025-0719 [doi] PST - epublish SO - J Pediatr Endocrinol Metab. 2026 Apr 24;39(5):425-431. doi: 10.1515/jpem-2025-0719. Print 2026 May 26. PMID- 42044770 OWN - NLM STAT- MEDLINE DCOM- 20260606 LR - 20260726 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 123 IP - 6 DP - 2026 Jun TI - Differential associations between menstrual blood loss scores and iron status in East Asian and Northern European individuals: findings from a cross-sectional analysis of the Iron Genes in East Asian and Northern European Adults Study (FeGenes) cohort. PG - 101326 LID - S0002-9165(26)00135-8 [pii] LID - 10.1016/j.ajcnut.2026.101326 [doi] LID - 101326 AB - BACKGROUND: Healthy adult females of East Asian (EA) ancestry have been reported to have higher iron (Fe) stores and Fe absorption and alterations in Fe regulatory hormones when compared with adult females of Northern European (NE) ancestry. OBJECTIVES: This cross-sectional study collected data on menstrual characteristics among adult females of genetically confirmed EA or NE ancestry and evaluated the potential impact of this factor on Fe status. METHODS: Data were obtained from premenopausal females aged 18 to 50 y [BMI (in kg/m(2)) 18-30] who were enrolled in the FeGenes study, which recruited healthy individuals of genetically confirmed EA or NE ancestry. Data on age at menarche, cycle frequency, menstrual bleeding duration, and use of menstrual products were collected from self-reported questionnaires, and menstrual blood loss (MBL) scores were calculated. Fe status was assessed through serum ferritin (microgram per liter), hepcidin (nanograms per milliliter), soluble transferrin (TF) receptor (milligram per liter), TF (milligram per deciliter), and calculated total body Fe (milligrams per kilogram). Group comparisons and associations with Fe status biomarkers were examined. RESULTS: EA females had an earlier median age at menarche [EA: 12.0 (IQR: 11.0, 13.0) y; NE: 13.0 (IQR: 12.0, 13.3) y; P = 0.002] and a higher MBL score [EA: 24.0 (IQR:17.5, 31.5); NE: 16.0 (IQR: 10.5, 27.9); P < 0.001] than NE females. In NE individuals, a higher MBL score was significantly associated with lower log-transformed serum ferritin (beta: ‒0.01; SE: 0.005; P = 0.004), total body Fe (beta: ‒0.06; SE: 0.02; P = 0.002), and higher log-transformed soluble TF receptor (beta: 0.005; SE: 0.001; P = 0.002). No associations between MBL score and Fe status were evident in EA females. CONCLUSIONS: Higher MBL scores are associated with lower Fe status in NE but not EA females. Greater attention and validated metrics are needed to evaluate MBL and better quantify Fe needs in reproductive-aged females. This trial was registered at clinicaltrials.gov as NCT04198545. CI - Copyright (c) 2026 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Lee, Min-Ruei AU - Lee MR AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Barad, Alexa AU - Barad A AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Bender, Erica AU - Bender E AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Thompson, Jennifer AU - Thompson J AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Gu, Zhenglong AU - Gu Z AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Pressman, Eva K AU - Pressman EK AD - Department of Obstetrics and Gynecology, University of Rochester Medical Center, Rochester, NY, United States. FAU - O'Brien, Kimberly O AU - O'Brien KO AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. Electronic address: koo4@cornell.edu. LA - eng SI - ClinicalTrials.gov/NCT04198545 GR - R01 DK122216/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20260425 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 RN - 9007-73-2 (Ferritins) RN - 0 (Hepcidins) RN - E1UOL152H7 (Iron) RN - 0 (Receptors, Transferrin) RN - 0 (Transferrin) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Middle Aged MH - Young Adult MH - Cohort Studies MH - Cross-Sectional Studies MH - Ferritins/blood MH - Hepcidins/blood MH - *Iron/blood/metabolism MH - *Menarche MH - Menorrhagia/blood MH - *Menstruation MH - Receptors, Transferrin/blood MH - Transferrin/metabolism MH - White People MH - East Asian People PMC - PMC13265119 MID - NIHMS2178913 OTO - NOTNLM OT - East Asian OT - Northern European OT - age at menarche OT - ancestry OT - iron deficiency OT - menstrual blood loss OT - serum ferritin OT - total body iron COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/04/28 00:33 MHDA- 2026/06/06 18:42 PMCR- 2027/04/25 CRDT- 2026/04/27 19:13 PHST- 2025/12/10 00:00 [received] PHST- 2026/03/27 00:00 [revised] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/06/06 18:42 [medline] PHST- 2026/04/28 00:33 [pubmed] PHST- 2026/04/27 19:13 [entrez] PHST- 2027/04/25 00:00 [pmc-release] AID - S0002-9165(26)00135-8 [pii] AID - 101326 [pii] AID - 10.1016/j.ajcnut.2026.101326 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 Jun;123(6):101326. doi: 10.1016/j.ajcnut.2026.101326. Epub 2026 Apr 25. PMID- 42044742 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260916 IS - 2212-2672 (Print) IS - 2212-2672 (Linking) VI - 126 IP - 9 DP - 2026 Sep TI - Application of the Total Nutrient Index as a Precision Nutrition Tool to Address Dietary Recommendations Across the Life Course. PG - 156368 LID - S2212-2672(26)00083-3 [pii] LID - 10.1016/j.jand.2026.156368 [doi] AB - BACKGROUND: Indexes are a standardized tool for assessing dietary exposures from foods/beverages (F&B) and have recently been extended to include dietary supplements (DS). The Total Nutrient Index (TNI) (F&B + DS) and the Food Nutrient Index (FNI) (F&B only) were developed to assess micronutrient intakes relative to Dietary Reference Intakes for micronutrients and were previously examined for relative validity among US adults. OBJECTIVE: This study examined the micronutrient quality (ie, TNI and FNI) of the diet across all age groups and compared TNI and FNI total and component scores with Healthy Eating Index 2020 scores among the US population. This analysis also sought to demonstrate the flexibility of the TNI and FNI frameworks across the life course. DESIGN: A nationally representative, cross-sectional analysis of the 2015-2020 National Health and Nutrition Examination Survey demographic, dietary, and dietary supplement data (ie, 24-hour dietary recall and DS inventory) was conducted among the US population. PARTICIPANTS AND SETTING: This study included US adults and children (aged 1 year and older; n = 19 903) who participated in the 2015-2020 National Health and Nutrition Examination Survey. MAIN OUTCOMES: The main outcome measures were TNI and FNI total and component scores (range = 0 to 100) overall and by age group, with higher scores indicating greater adherence to the Dietary Reference Intakes. STATISTICAL ANALYSES PERFORMED: TNI and FNI scores were calculated via the simple algorithm method, for 11 age group-dependent micronutrients (calcium, choline, magnesium, phosphorus, potassium, and vitamins A, B12, C, D, E, and K), and compared with Healthy Eating Index 2020 scores. RESULTS: Americans scored 72 out of 100 on TNI, but scores varied by age and were higher for the TNI than FNI ( approximately 3 to 11 points.). Younger children (aged 1 to 3 years, TNI = 87; aged 4 to 8 years, TNI = 82) and older adults (aged 71 years and older, TNI = 77) exhibited higher TNI scores than other ages, due to higher calcium, magnesium, and vitamins A, C, and B12 intake. Healthy Eating Index 2020 total scores were low (52) overall and followed similar scoring trajectories by age group as the TNI and FNI. CONCLUSIONS: Evaluating total dietary exposures is important, considering the differential intake patterns from F&B, vs those with DS. Given low Dietary Reference Intakes adherence for some nutrients across the life span, these findings warrant improved diet quality and micronutrient density for many, to optimize nutrition and reduce diet-related chronic disease risk among Americans. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Cowan-Pyle, Alexandra E AU - Cowan-Pyle AE AD - Institute for Connecting Nutrition and Health, Florida State University, Tallahassee, Florida; Department of Behavioral Sciences and Social Medicine, College of Medicine, Florida State University, Tallahassee, Florida. Electronic address: aecowan@fsu.edu. FAU - Tooze, Janet A AU - Tooze JA AD - Department of Biostatistics and Data Science, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina. FAU - Reynolds, Lindsay M AU - Reynolds LM AD - Department of Epidemiology and Prevention, Wake Forest School of Medicine, Wake Forest University, Winston-Salem, North Carolina. FAU - Gahche, Jaime J AU - Gahche JJ AD - Office of Dietary Supplements, National Institutes of Health, Bethesda, Maryland. FAU - Dwyer, Johanna T AU - Dwyer JT AD - Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts. FAU - Mitchell, Diane C AU - Mitchell DC AD - Institute for Advancing Health Through Agriculture, Texas A&M AgriLife Research, Texas A&M University System, College Station, Texas. FAU - Carroll, Raymond J AU - Carroll RJ AD - Department of Statistics, Texas A&M University, College Station, Texas. FAU - Mallick, Bani K AU - Mallick BK AD - Department of Statistics, Texas A&M University, College Station, Texas. FAU - Bailey, Regan L AU - Bailey RL AD - Institute for Connecting Nutrition and Health, Florida State University, Tallahassee, Florida; Department of Behavioral Sciences and Social Medicine, College of Medicine, Florida State University, Tallahassee, Florida. LA - eng GR - U01 CA215834/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20260425 PL - United States TA - J Acad Nutr Diet JT - Journal of the Academy of Nutrition and Dietetics JID - 101573920 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Nutrition Surveys MH - Female MH - Male MH - Adult MH - Child, Preschool MH - Child MH - *Micronutrients/administration & dosage/analysis MH - Adolescent MH - Cross-Sectional Studies MH - Infant MH - Young Adult MH - *Recommended Dietary Allowances MH - Middle Aged MH - United States MH - Aged MH - Dietary Supplements MH - *Nutrition Assessment MH - *Diet, Healthy/statistics & numerical data MH - *Diet/standards MH - Nutrition Policy PMC - PMC13575888 MID - NIHMS2205793 OTO - NOTNLM OT - Dietary Reference Intakes OT - Dietary Supplements OT - Micronutrients OT - NHANES OT - Total Nutrient Index COIS- STATEMENT OF POTENTIAL CONFLICT OF INTEREST Unrelated to this submission, A. E. Cowan-Pyle is a member of the Journal of the Academy of Nutrition and Dietetics Board of Editors, has previously served as a consultant to the National Pork Board, Think Healthy Group, and the General Mills Bell Institute, and has received travel support from the Council of Responsible Nutrition. R. L. Bailey has served as a consultant to the National Institutes of Health Office of Dietary Supplements, Nestle, the General Mills Bell Institute, RTI International, Think Healthy Group, and Nutrition Impact; is a former trustee of the International Food Information Council; and is a former board member of the International Life Sciences Institute-North America. She has received travel support to present her research on dietary supplements and is a former member of the Journal of Nutrition editorial board. J. T. Dwyer owns stock in several food and drug companies. Unrelated to this publication she serves on the scientific advisory committee of the McCormick Science Institute, the Mushroom Council, and served in the past on scientific advisory boards of Bay State Milling, the Singapore Institute of Food and Biotechnology Innovation and Nestle. She serves as an unpaid advisor to the Institute for the Advancement of Food and Nutrition Sciences Low Calorie Sweetener Committee and on the Bioactives Committee of the International Life Sciences Institute US-Canada Research Program and is editor of Nutrition Today. EDAT- 2026/04/28 00:35 MHDA- 2026/08/19 23:42 PMCR- 2026/09/15 CRDT- 2026/04/27 19:12 PHST- 2025/10/22 00:00 [received] PHST- 2026/03/13 00:00 [revised] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/08/19 23:42 [medline] PHST- 2026/04/28 00:35 [pubmed] PHST- 2026/04/27 19:12 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - S2212-2672(26)00083-3 [pii] AID - 10.1016/j.jand.2026.156368 [doi] PST - ppublish SO - J Acad Nutr Diet. 2026 Sep;126(9):156368. doi: 10.1016/j.jand.2026.156368. Epub 2026 Apr 25. PMID- 42044293 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260828 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Apr 27 TI - Comparing Perceptions of ChatGPT Use in Health Attitude Contexts Among Users and Nonusers: Cross-Sectional Study. PG - e79276 LID - 10.2196/79276 [doi] LID - e79276 AB - BACKGROUND: In light of the growing use of artificial intelligence (AI) in health care, individuals' access to and use of health information are transforming. ChatGPT, an AI chatbot, provides immediate responses to health queries, with the potential to influence health-related attitudes, thereby raising concerns related to privacy, reliability, and security. OBJECTIVE: This study aimed to investigate the perceived usefulness, risks, anxiety, and social influence of ChatGPT on health attitudes among users and nonusers in Saudi Arabia. METHODS: A cross-sectional study was conducted using an online survey based on a validated tool. In total, 337 participants aged 18 years and older responded to questions assessing their perceptions of ChatGPT on health-related attitudes. RESULTS: Data showed that 76.1% (194/255) of the respondents used ChatGPT, with the majority being younger and more highly educated. The main uses for health-related purposes were health education (43/194, 22.2%) and physical activity guidance (31/194, 16%). The analysis showed that users considered ChatGPT useful for health-related decisions, with 45.9% (89/194) finding it easy to learn and use, but concerns about privacy (106/194, 54.7%) and reliability (87/194, 44.9%) remained. Among nonusers, security risks (39/61, 63.9%) were the major barrier to using AI-based tools for health purposes, and 68.9% (42/61) found such tools attractive and engaging. There were no statistically significant differences between users and nonusers across all examined sociodemographic characteristics (P>.05). CONCLUSIONS: The study established the potential of ChatGPT in improving health decision-making and revealed cultural, privacy, and trust issues that may affect its implementation. These findings underscore the importance of strengthening the security of AI-based applications to enhance public acceptability of related health policies and to support the safe integration of tools such as ChatGPT into the health care system. CI - (c) Hessah Al Suwaidan, Arwa Althumairi, Saja A Al-Rayes, Khalid Alkhurayji. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Al Suwaidan, Hessah AU - Al Suwaidan H AUID- ORCID: 0000-0002-6535-8455 AD - Health Information Management and Technology Department, College of Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. FAU - Althumairi, Arwa AU - Althumairi A AUID- ORCID: 0000-0002-0371-408X AD - Health Information Management and Technology Department, College of Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. FAU - Al-Rayes, Saja A AU - Al-Rayes SA AUID- ORCID: 0000-0001-9908-7756 AD - Health Information Management and Technology Department, College of Public Health, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. FAU - Alkhurayji, Khalid AU - Alkhurayji K AUID- ORCID: 0009-0007-9394-1668 AD - Research, Statistics, and Information Department, Saudi Central Board for Accreditation of Healthcare Institutions, Wadi Alsaheya, Riyadh, 12264, Saudi Arabia, 966596181916. LA - eng PT - Journal Article DEP - 20260427 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Saudi Arabia MH - Female MH - Adult MH - Middle Aged MH - Surveys and Questionnaires MH - Adolescent MH - *Perception MH - Young Adult MH - Generative Artificial Intelligence MH - *Attitude to Health MH - Health Knowledge, Attitudes, Practice PMC - PMC13119390 OTO - NOTNLM OT - AI OT - ChatGPT OT - Saudi Arabia OT - artificial intelligence OT - health attitude OT - health informatics COIS- Conflicts of Interest: None declared. EDAT- 2026/04/27 18:33 MHDA- 2026/04/27 18:34 PMCR- 2026/04/27 CRDT- 2026/04/27 14:44 PHST- 2025/06/18 00:00 [received] PHST- 2026/03/10 00:00 [revised] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/04/27 18:34 [medline] PHST- 2026/04/27 18:33 [pubmed] PHST- 2026/04/27 14:44 [entrez] PHST- 2026/04/27 00:00 [pmc-release] AID - v10i1e79276 [pii] AID - 79276 [pii] AID - 10.2196/79276 [doi] PST - epublish SO - JMIR Form Res. 2026 Apr 27;10:e79276. doi: 10.2196/79276. PMID- 42044135 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260827 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 4 DP - 2026 TI - Effects of transcutaneous electrical phrenic nerve stimulation and transcutaneous electrical diaphragmatic stimulation: A protocol for a randomized, single-blind, crossover trial. PG - e0347493 LID - 10.1371/journal.pone.0347493 [doi] LID - e0347493 AB - BACKGROUND: Patients in the intensive care unit (ICU) are at high risk of developing respiratory muscle weakness, which may lead to prolonged mechanical ventilation and worsening clinical outcomes. Noninvasive neuromuscular electrical stimulation techniques, such as transcutaneous electrical phrenic nerve stimulation (TEPNS) and transcutaneous diaphragmatic electrical stimulation (TDES), offer potential therapeutic options for patients unable to generate voluntary active contractions. However, there is limited research directly comparing the effects of these modalities on diaphragmatic function. The primary objective of this study is to evaluate the effects of TEPNS and TDES on diaphragmatic function in healthy adults. Secondary objectives include assessing the safety, feasibility, and perceived discomfort associated with the application of each technique. METHODS: This study will be a bicentric, randomized, single-blind, crossover trial that will be conducted at two hospitals in Sao Paulo, Brazil. Healthy adults aged 18-60, with a BMI between 18.5 and 24.9 kg/m2, no history of respiratory diseases, and no contraindications for the proposed electrical stimulation modalities will be included. Diaphragm thickness, thickening fraction, and mobility will be assessed using ultrasound during tidal breathing. Participants will be randomly assigned to begin the intervention with one of two experimental conditions: (1) TEPNS protocol or (2) TDES protocol. In addition, data on the safety and feasibility of each electrical stimulation modalities will also be collected. TRIAL REGISTRATION: This protocol is registered at ClinicalTrials.gov under the number NCT06339632. CI - Copyright: (c) 2026 Mol et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Mol, Caroline Gomes AU - Mol CG AUID- ORCID: 0000-0001-9493-0150 AD - Department of Critical Care Medicine, Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil. AD - Faculdade Israelita de Ciencias da Saude Albert Einstein, Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil. FAU - Nawa, Ricardo Kenji AU - Nawa RK AUID- ORCID: 0000-0002-0852-7013 AD - Department of Critical Care Medicine, Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil. AD - Faculdade Israelita de Ciencias da Saude Albert Einstein, Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil. FAU - Britto, Angelica Cristiane da Cruz AU - Britto ACDC AD - Faculdade Israelita de Ciencias da Saude Albert Einstein, Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil. AD - Department of Medical and Surgical Clinical Care, Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil. FAU - Eid, Raquel Afonso Caserta AU - Eid RAC AD - Department of Critical Care Medicine, Hospital Israelita Albert Einstein, Sao Paulo, SP, Brazil. FAU - Campos, Elaine Cristina de AU - Campos EC AD - Rehabilitation Service, Hospital Sirio-Libanes, Sao Paulo, SP, Brazil. FAU - Saraiva, Leandro Teixeira AU - Saraiva LT AUID- ORCID: 0000-0001-9902-5870 AD - Rehabilitation Service, Hospital Sirio-Libanes, Sao Paulo, SP, Brazil. FAU - Righetti, Renato Fraga AU - Righetti RF AD - Rehabilitation Service, Hospital Sirio-Libanes, Sao Paulo, SP, Brazil. FAU - Yamaguti, Wellington Pereira AU - Yamaguti WP AUID- ORCID: 0000-0003-4943-2085 AD - Rehabilitation Service, Hospital Sirio-Libanes, Sao Paulo, SP, Brazil. LA - eng SI - ClinicalTrials.gov/NCT06339632 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260427 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Transcutaneous Electric Nerve Stimulation/methods/adverse effects MH - *Diaphragm/physiology/innervation MH - Adult MH - Single-Blind Method MH - *Phrenic Nerve/physiology MH - Cross-Over Studies MH - Middle Aged MH - Female MH - Young Adult MH - Adolescent MH - Male MH - Randomized Controlled Trials as Topic MH - Brazil PMC - PMC13119898 COIS- The authors have declared that no competing interests exist. EDAT- 2026/04/27 18:34 MHDA- 2026/04/27 18:35 PMCR- 2026/04/27 CRDT- 2026/04/27 13:37 PHST- 2025/12/22 00:00 [received] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/04/27 18:35 [medline] PHST- 2026/04/27 18:34 [pubmed] PHST- 2026/04/27 13:37 [entrez] PHST- 2026/04/27 00:00 [pmc-release] AID - PONE-D-25-67090 [pii] AID - 10.1371/journal.pone.0347493 [doi] PST - epublish SO - PLoS One. 2026 Apr 27;21(4):e0347493. doi: 10.1371/journal.pone.0347493. eCollection 2026. PMID- 42043773 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260826 IS - 1572-8773 (Electronic) IS - 0966-0844 (Linking) VI - 39 IP - 5 DP - 2026 Oct TI - Bioaccumulation and nutritional impact of fluoride in Pleurotus ostreatus and Pleurotus djamor with human health risk assessment. PG - 1649-1668 LID - 10.1007/s10534-026-00820-y [doi] AB - Pleurotus species are nutritionally rich fungi, yet their potential to bioaccumulate environmental fluoride (F(-)) necessitates careful scientific evaluation further. In this study, Pleurotus mushrooms cultivated on F(-) enriched substrates exhibited significant bioaccumulation of F(-), indicating their sensitivity to substrate quality and environmental contamination. Supplementation with calcium (Ca) played a crucial physiological role by reducing F(-) toxicity within the fruiting bodies of mushroom, although its effects were species dependent. Notably, Ca addition mitigated F(-) stress at the biochemical and cellular level in Pleurotus ostreatus, whereas P. djamor experienced a reduction in growth performance, demonstrating differential tolerance mechanisms. Molecular-level assessment through FTIR-spectroscopy highlighted marked alterations in functional groups associated with proteins, lipids, and carbohydrates under combined F(-) and Ca exposure, emphasizing stress-induced metabolic shifts. Field-based evaluations further validated laboratory observations, revealing substantial F(-) accumulation in mushrooms grown using fluoridated-straw and F(-) rich groundwater, particularly in Set 1N (96.6 mg/kg-dw) and Set 4N (46 mg/kg-dw). Subcellular fractionation studies confirmed that accumulated fluoride predominantly localized within the cell wall fraction, suggesting a sequestration strategy for detoxification. Bioconcentration factor (BCF) analysis indicated higher accumulation in P. ostreatus relative to P. djamor. However, despite partial mitigation by Ca supplementation and health risk assessments demonstrated that both mushroom species exceeded the non-carcinogenic risk threshold for children when cultivated in traditional way under contaminated conditions. These findings underscore the importance of using controlled, F(-) free substrates and clean irrigation sources to ensure food safety and promote sustainable mushroom cultivation practices, particularly in fluoride-affected regions such as West Bengal, India. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature B.V. FAU - De, Ayan AU - De A AD - School of Environmental Studies, Jadavpur University, Kolkata, West Bengal, 700032, India. FAU - Sarkar, Jit AU - Sarkar J AD - Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, Centre of Advanced Study, University of Calcutta, Kolkata, West Bengal, 700019, India. FAU - Das, Diptosh AU - Das D AD - Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, Centre of Advanced Study, University of Calcutta, Kolkata, West Bengal, 700019, India. FAU - Mridha, Deepanjan AU - Mridha D AD - School of Environmental Studies, Jadavpur University, Kolkata, West Bengal, 700032, India. FAU - Let, Moitri AU - Let M AD - Microbiology Section, Department of Botany, The University of Burdwan, Burdwan, West Bengal, 713104, India. FAU - Gangopadhyay, Bhuban AU - Gangopadhyay B AD - Department of Polymer Science and Technology, University of Calcutta, 92 A. P. C. Road, Kolkata, West Bengal, 700019, India. FAU - Sarkar, Kunal AU - Sarkar K AD - Department of Zoology, Ballygunge Science College, University of Calcutta, Kolkata, West Bengal, 700019, India. FAU - Das, Madhusudan AU - Das M AD - Department of Zoology, Ballygunge Science College, University of Calcutta, Kolkata, West Bengal, 700019, India. FAU - Roychowdhury, Tarit AU - Roychowdhury T AD - School of Environmental Studies, Jadavpur University, Kolkata, West Bengal, 700032, India. FAU - Archarya, Krishnendu AU - Archarya K AD - Molecular and Applied Mycology and Plant Pathology Laboratory, Department of Botany, Centre of Advanced Study, University of Calcutta, Kolkata, West Bengal, 700019, India. FAU - Bandopadhyay, Rajib AU - Bandopadhyay R AD - Microbiology Section, Department of Botany, The University of Burdwan, Burdwan, West Bengal, 713104, India. FAU - Panja, Anindya Sundar AU - Panja AS AD - Molecular Informatics Laboratory, Department of Biotechnology, Oriental Institute of Science and Technology, Vidyasagar University, Midnapore, West Bengal, 721102, India. biotech2ani@gmail.com. LA - eng PT - Journal Article DEP - 20260427 PL - Netherlands TA - Biometals JT - Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine JID - 9208478 RN - Q80VPU408O (Fluorides) RN - SY7Q814VUP (Calcium) SB - IM MH - *Pleurotus/metabolism/growth & development/chemistry/drug effects MH - *Fluorides/metabolism/toxicity MH - Humans MH - Risk Assessment MH - Calcium/pharmacology/metabolism MH - Fruiting Bodies, Fungal/metabolism/drug effects/growth & development MH - Spectroscopy, Fourier Transform Infrared OTO - NOTNLM OT - Pleurotus sp. OT - Calcium (Ca) OT - FTIR OT - Fluoride (F(-)) OT - Health risk assessment OT - Subcellular fractionation COIS- Declarations. Competing interest: The authors declare no competing interests. EDAT- 2026/04/27 12:34 MHDA- 2026/08/26 17:37 CRDT- 2026/04/27 11:25 PHST- 2025/11/24 00:00 [received] PHST- 2026/04/15 00:00 [accepted] PHST- 2026/08/26 17:37 [medline] PHST- 2026/04/27 12:34 [pubmed] PHST- 2026/04/27 11:25 [entrez] AID - 10.1007/s10534-026-00820-y [pii] AID - 10.1007/s10534-026-00820-y [doi] PST - ppublish SO - Biometals. 2026 Oct;39(5):1649-1668. doi: 10.1007/s10534-026-00820-y. Epub 2026 Apr 27. PMID- 42043699 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260813 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Apr 27 TI - A systematic review of psychometric scales that assess familial, lifestyle, and behavioural factors for children living with overweight or obesity, or at risk of developing obesity. LID - 10.1007/s40519-026-01860-6 [doi] LID - 56 AB - Over the past four decades, global childhood obesity rates have risen significantly. Modifiable factors such as diet, physical activity, family dynamics, and screen time play an important role in childhood obesity and are often targeted in interventions. However, no comprehensive review of instruments assessing these factors has been published, prompting this study. A systematic review following PRISMA guidelines was conducted to identify validated multidimensional lifestyle assessment instruments (defined as those assessing at least two constructs) for children aged 2-12 years living with overweight or obesity. Four databases (Pubmed, PsychINFO, CINAHL, and Embase) were searched for studies from 1980 to 2024. First, 7844 studies were screened by title and abstract by two independent reviewers. The resultant 141 full-text studies were also independently reviewed by 2 reviewers. Study quality was assessed and data on psychometric properties were extracted. Thirteen papers covering eight instruments were included: Healthy Kids (Ninos Sanos), Family Health Behaviour Scale, Lifestyle Behaviour Checklist, Family Nutrition Physical Activity screening tool, Family Eating and Activity Habits Questionnaire, Home Environment Survey, Child Obesity Risk Questionnaire 2-5, and Energy Retention Behaviour Scale for Children. These instruments assessed various factors, including diet, mealtime routines, physical activity, sedentary behaviour, sleep, parental beliefs and the home environment. The instruments showed significant heterogeneity, with no single instrument covering the entire 2-12 years age range or measuring the same constructs comprehensively. The quality of the reviewed studies varied, particularly in the range of psychometric properties examined. Based on the results of this review, there is no one measure shown to be validated specifically for children living with overweight/obesity that addresses a broad range of domains that respond to change over time.Level II: Evidence obtained from well-designed controlled trials without randomisation. CI - (c) 2026. The Author(s). FAU - Davis, Brid Aine AU - Davis BA AUID- ORCID: 0000-0003-4606-4432 AD - School of Psychology, University College Dublin, Belfield, Dublin 4, Ireland. FAU - O'Dwyer, Claire AU - O'Dwyer C AUID- ORCID: 0000-0002-7978-9731 AD - School of Psychology, University College Dublin, Belfield, Dublin 4, Ireland. FAU - Carr, Alan AU - Carr A AUID- ORCID: 0000-0003-4563-8852 AD - School of Psychology, University College Dublin, Belfield, Dublin 4, Ireland. FAU - Looney, Kathy AU - Looney K AUID- ORCID: 0000-0002-0815-2012 AD - School of Psychology, University College Dublin, Belfield, Dublin 4, Ireland. kathy.looney@ucd.ie. LA - eng GR - D Psych Sc/Health Service Executive/ PT - Journal Article PT - Systematic Review DEP - 20260427 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - *Psychometrics MH - Pediatric Obesity/epidemiology/psychology MH - *Overweight/epidemiology/psychology MH - Family/psychology MH - Exercise/statistics & numerical data MH - Health Behavior/physiology MH - Life Style MH - Humans MH - Child, Preschool MH - Child MH - Risk Factors PMC - PMC13253707 OTO - NOTNLM OT - Childhood obesity OT - health-related quality of life (HRQOL) OT - lifestyle measures COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/04/27 12:34 MHDA- 2026/06/15 11:32 PMCR- 2026/04/27 CRDT- 2026/04/27 11:23 PHST- 2024/06/17 00:00 [received] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/06/15 11:32 [medline] PHST- 2026/04/27 12:34 [pubmed] PHST- 2026/04/27 11:23 [entrez] PHST- 2026/04/27 00:00 [pmc-release] AID - 10.1007/s40519-026-01860-6 [pii] AID - 1860 [pii] AID - 10.1007/s40519-026-01860-6 [doi] PST - epublish SO - Eat Weight Disord. 2026 Apr 27;31(1):56. doi: 10.1007/s40519-026-01860-6. PMID- 42041084 OWN - NLM STAT- MEDLINE DCOM- 20260927 LR - 20260927 IS - 1940-1019 (Electronic) IS - 0022-3980 (Linking) VI - 160 IP - 8 DP - 2026 TI - The Effect of Weight Stigma on Adolescent Health: Mediating and Moderating Roles of Social Support and Personality Traits. PG - 985-1008 LID - 10.1080/00223980.2026.2661586 [doi] AB - Weight stigma is a common psychosocial stressor among adolescents and an important determinant of mental and physical well-being. However, the mechanisms through which it affects health outcomes remain insufficiently understood. This study explored the mediating and moderating roles of personality traits and perceived social support in the relationship between weight stigma and health outcomes in adolescents. A cross-sectional self-report study was conducted with 1,011 high school students (59.64% female; M(age) = 16.50 years, SD(age) = 1.10), using validated measures of weight stigma, Big Five personality traits, perceived social support, mental health (anxiety, depression, stress), and somatization. Mediation and moderation were tested using path analysis models, controlling for gender and BMI. Results showed that weight stigma directly predicted higher anxiety, depression, stress, and somatization. Positive indirect effects of weight stigma on health outcomes were observed through neuroticism, family support, and teacher support. Frequent stigmatization predicted lower levels of perceived social support and higher neuroticism, which in turn predicted poorer health outcomes. Moderation analyses showed that higher neuroticism and extraversion increased the effects of weight stigma on anxiety, while extraversion buffered its effects on somatization. Interestingly, while family support generally serves as a protective factor against somatization, higher levels of support were associated with a stronger effect of weight stigma on somatization. These findings emphasize the complex interplay between weight stigma, individual traits, and social context, supporting a biopsychosocial understanding of adolescent health. Furthermore, they emphasize the need for a comprehensive prevention and intervention approach to support this vulnerable population. FAU - Ivancic, Ivana AU - Ivancic I AUID- ORCID: 0009-0008-9583-2649 AD - University of Rijeka. FAU - Kalebic Maglica, Barbara AU - Kalebic Maglica B AUID- ORCID: 0000-0002-6278-5582 AD - University of Rijeka. FAU - Kurtovic, Ana AU - Kurtovic A AUID- ORCID: 0000-0003-0779-5312 AD - Josip Juraj Strossmayer University of Osijek. LA - eng PT - Journal Article DEP - 20260427 PL - United States TA - J Psychol JT - The Journal of psychology JID - 0376332 SB - IM MH - Humans MH - Female MH - Adolescent MH - *Social Support MH - Male MH - *Personality MH - *Social Stigma MH - Cross-Sectional Studies MH - *Anxiety/psychology MH - *Depression/psychology MH - *Adolescent Health MH - *Stress, Psychological/psychology MH - Somatoform Disorders/psychology OTO - NOTNLM OT - Weight stigma OT - adolescents OT - big five personality traits OT - mental health OT - social support EDAT- 2026/04/27 12:34 MHDA- 2026/09/27 23:28 CRDT- 2026/04/27 07:33 PHST- 2026/09/27 23:28 [medline] PHST- 2026/04/27 12:34 [pubmed] PHST- 2026/04/27 07:33 [entrez] AID - 10.1080/00223980.2026.2661586 [doi] PST - ppublish SO - J Psychol. 2026;160(8):985-1008. doi: 10.1080/00223980.2026.2661586. Epub 2026 Apr 27. PMID- 42040637 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260427 LR - 20260813 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - The importance of physical education and the intention to be physically active as predictors of subjective well-being in secondary school adolescents. PG - 1748124 LID - 10.3389/fspor.2026.1748124 [doi] LID - 1748124 AB - INTRODUCTION: In recent years, concerns about adolescent mental health and declining physical activity levels have increased across European educational systems, including Portugal. Understanding how Physical Education (PE) and students' intention to remain physically active contribute to subjective well-being is therefore essential for guiding educational practices and health promotion strategies. Within this context, the present study aimed to analyze these relationships in a group of secondary school students in Portugal, with a view to proposing evidence-based recommendations. This study aimed to analyze the role of the importance attributed to Physical Education (PE) and the intention to be physically active as significant statistical predictors of subjective well-being (SWB) in Portuguese secondary school adolescents. METHODS: The sample consisted of 560 students, aged between 16 and 19 years, from different regions of Portugal. Validated scales were used to measure the variables of interest: Importance of PE, Intention to Be Active, Positive and Negative Affect, and Life Satisfaction. The data were analyzed using descriptive statistics, Spearman correlations, Kruskal-Wallis and Mann-Whitney tests, linear regressions, and simple mediation models (Hayes' model 4). RESULTS: The results indicated high levels of physical activity intention and life satisfaction, low levels of negative affect, and strong internal consistency in the scales used. The importance attributed to PE and the intention to be active were significantly associated with positive affect and life satisfaction, with intention partially mediating the relationship between the importance of PE and positive affect, and fully mediating the relationship with negative affect. No significant mediation was found for life satisfaction. Additionally, significant differences were observed across school years, highlighting the 11th year as a stage of greater emotional vulnerability.x. DISCUSSION: The findings suggest the need to reinforce the value of PE in the curriculum and to promote educational strategies that encourage regular physical activity as a way to enhance SWB in the school context. CI - (c) 2026 Batista, Rojo-Ramos, Castillo-Paredes and Galan-Arroyo. FAU - Batista, Marco AU - Batista M AD - Polytechnic University of Castelo Branco, Castelo Branco, Portugal. AD - SPRINT-IPCB, Sport Physical Activity and Health Research & Innovation Center, Castelo Branco, Portugal. FAU - Rojo-Ramos, Jorge AU - Rojo-Ramos J AD - Promoting a Healthy Society Research Group (PHeSO), Faculty of Sport Sciences, University of Extremadura, Caceres, Spain. FAU - Castillo-Paredes, Antonio AU - Castillo-Paredes A AD - Grupo AFySE, Investigacion en Actividad Fisica y Salud Escolar, Escuela de Pedagogia en Educacion Fisica, Facultad de Educacion, Universidad de Las Americas, Santiago, Chile. FAU - Galan-Arroyo, Carmen AU - Galan-Arroyo C AD - Promoting a Healthy Society Research Group (PHeSO), Faculty of Sport Sciences, University of Extremadura, Caceres, Spain. LA - eng PT - Journal Article DEP - 20260410 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13106526 OTO - NOTNLM OT - adolescence OT - behavioral intention OT - physical activity OT - physical education OT - subjective well-being COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/27 12:34 MHDA- 2026/04/27 12:35 PMCR- 2026/04/10 CRDT- 2026/04/27 07:09 PHST- 2025/11/17 00:00 [received] PHST- 2026/03/14 00:00 [revised] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/04/27 12:35 [medline] PHST- 2026/04/27 12:34 [pubmed] PHST- 2026/04/27 07:09 [entrez] PHST- 2026/04/10 00:00 [pmc-release] AID - 10.3389/fspor.2026.1748124 [doi] PST - epublish SO - Front Sports Act Living. 2026 Apr 10;8:1748124. doi: 10.3389/fspor.2026.1748124. eCollection 2026. PMID- 42040062 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Do nutrition knowledge and health literacy influence food consumption patterns in Saudi youth aged 18 to 25? An analytical assessment using cross-sectional convenience sample. PG - 1806616 LID - 10.3389/fpubh.2026.1806616 [doi] LID - 1806616 AB - OBJECTIVE: Nutrition knowledge and health literacy are critical foundations for healthy dietary behaviors. However, their combined influence on food consumption patterns in Saudi young adults remains underexplored. This research investigated the levels and predictors of nutrition knowledge and health literacy, as well as their impact on food consumption patterns among a group of Saudi Arabian young people. METHODS: This was an online survey (structured, self-administered questionnaire) using a large convenience sample of students from different universities in Saudi Arabia. Nutrition knowledge, health literacy, and food consumption patterns were evaluated using the validated CoNKS, the HLS-EU-Q16, and a regionally adapted 10-item food group checklist, respectively. Regression models were fitted to evaluate the predictors of nutrition knowledge and health literacy, and their associations with food consumption frequency. RESULTS: The sample comprised 827 participants, aged 18 to 25. The prevalence of unsatisfactory nutrition knowledge was 70.5% and limited health literacy was 58.3%. Significant factors associated with unsatisfactory nutrition knowledge included non-health science major, physical inactivity, no prior nutrition course, night eating syndrome, and limited health literacy. Key factors associated with limited health literacy included age (18-20 years), non-health science major, having an illiterate mother, and unsatisfactory nutrition knowledge. Furthermore, satisfactory nutrition knowledge and sufficient health literacy were independently associated with healthier food consumption patterns. Specifically, they were linked to higher odds of consuming fruits and vegetables (nutrition knowledge: OR = 1.76; health literacy: OR = 2.71) and meat, fish, and eggs (nutrition knowledge: OR = 2.67). Unsatisfactory nutrition knowledge was related to high-calorie foods intake (OR = 3.70). CONCLUSION: Both nutrition knowledge and health literacy are significant, modifiable factors associated with food consumption patterns among study participants. Integrated educational interventions targeting both competencies are recommended to improve dietary behaviors in this population. CI - Copyright (c) 2026 Alzain. FAU - Alzain, Mohannad A AU - Alzain MA AD - Department of Family Medicine, Faculty of Medicine, King Abdul Aziz University, Jeddah, Saudi Arabia. AD - Department of Family Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia. AD - Family Medicine and Chronic Diseases Research Unit, King Fahd Medical Research Center, King Abdul Aziz University, Jeddah, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260409 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Saudi Arabia MH - *Health Literacy/statistics & numerical data MH - Female MH - Adolescent MH - Young Adult MH - Male MH - *Health Knowledge, Attitudes, Practice MH - Cross-Sectional Studies MH - Adult MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires MH - Students/statistics & numerical data/psychology PMC - PMC13102618 OTO - NOTNLM OT - Saudi Arabia OT - dietary behaviors OT - food consumption patterns OT - health literacy OT - nutrition knowledge OT - young adults COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/27 12:34 MHDA- 2026/04/27 12:35 PMCR- 2026/04/09 CRDT- 2026/04/27 07:05 PHST- 2026/02/08 00:00 [received] PHST- 2026/03/19 00:00 [revised] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/04/27 12:35 [medline] PHST- 2026/04/27 12:34 [pubmed] PHST- 2026/04/27 07:05 [entrez] PHST- 2026/04/09 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1806616 [doi] PST - epublish SO - Front Public Health. 2026 Apr 9;14:1806616. doi: 10.3389/fpubh.2026.1806616. eCollection 2026. PMID- 42039897 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260427 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Associations between food preferences, micronutrient insufficiency, and autonomic function in adolescents with a recent history of vasovagal syncope. PG - 1783737 LID - 10.3389/fnut.2026.1783737 [doi] LID - 1783737 AB - AIM OF THE STUDY: This study aimed to investigate the interrelationships between food preferences, micronutrient status, and autonomic function in adolescents with vasovagal syncope (VVS), exploring how dietary behaviour may contribute to syncope susceptibility. MATERIALS AND METHODS: We enrolled 138 adolescents with VVS and 78 age-matched healthy controls (13-17 years). Clinical assessment included syncope history, Modified Calgary Syncope Score (MCSS), and 24-h Holter monitoring for heart rate variability (HRV) analysis (SDANN, RMSSD, pNN50, TP, VLF, LF, HF, and LF/HF). Fasting serum levels of vitamins B6, B12, folate, and 25-hydroxyvitamin D (25(OH)D) were measured via ELISA. Food preferences were evaluated using a validated Ukrainian version of the Food Preference Questionnaire (FPQ) for adolescents and adults, covering vegetables, fruits, meat and fish, dairy, snacks, and starches. Data were analyzed using multiple linear regression, with assessment of FPQ reliability, construct, and discriminant validity. RESULTS: Adolescents with VVS exhibited lower serum B6, B12, and 25(OH)D compared with controls, while folate levels were similar. HRV analysis demonstrated increased TP alongside elevated LF/HF ratios, suggesting altered autonomic regulation characterized by relative sympathetic predominance and reduced parasympathetic modulation at baseline. The FPQ demonstrated high reliability and validity. VVS participants reported lower preferences for vegetables, meat and fish, and starches (all FDR-corrected), with a trend toward lower fruit preference that did not survive correction. Regression analyses showed that higher vegetable preference was associated with increased folate and cobalamin, whereas meat and fish preference was positively associated with B6. Vegetable preference was negatively associated with HF, while meat and fish and dairy preferences were negatively associated with SDANN and RMSSD. Dairy preference showed a negative association with B6 and multiple HRV parameters, while snack and starch preference had modest or no associations. Food preferences were generally weakly related to syncope severity, with only starch preference showing a significant association with MCSS scores after FDR correction. CONCLUSION: Adolescents with VVS exhibit distinct food preference patterns linked to micronutrient insufficiencies and altered HRV, suggesting an interaction between diet, nutrient status, and autonomic regulation. Integrating nutritional assessment and targeted interventions into clinical management may improve autonomic balance and reduce syncope burden. Future longitudinal and interventional studies are needed to clarify causal pathways and evaluate the efficacy of dietary and supplementation strategies in mitigating VVS episodes. CI - Copyright (c) 2026 Kovalchuk and Boyarchuk. FAU - Kovalchuk, Tetiana AU - Kovalchuk T AD - Department of Pediatrics, Ivan Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine, Ternopil, Ukraine. FAU - Boyarchuk, Oksana AU - Boyarchuk O AD - Department of Pediatrics and Pediatric Surgery, Ivan Horbachevsky Ternopil National Medical University of the Ministry of Health of Ukraine, Ternopil, Ukraine. LA - eng PT - Journal Article DEP - 20260409 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13102588 OTO - NOTNLM OT - 25-hydroxyvitamin D OT - cobalamin OT - folate OT - food preferences OT - heart rate variability OT - pediatric vasovagal syncope OT - pyridoxine COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/27 12:33 MHDA- 2026/04/27 12:34 PMCR- 2026/04/09 CRDT- 2026/04/27 07:03 PHST- 2026/01/08 00:00 [received] PHST- 2026/03/10 00:00 [revised] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/04/27 12:34 [medline] PHST- 2026/04/27 12:33 [pubmed] PHST- 2026/04/27 07:03 [entrez] PHST- 2026/04/09 00:00 [pmc-release] AID - 10.3389/fnut.2026.1783737 [doi] PST - epublish SO - Front Nutr. 2026 Apr 9;13:1783737. doi: 10.3389/fnut.2026.1783737. eCollection 2026. PMID- 42039321 OWN - NLM STAT- MEDLINE DCOM- 20260716 LR - 20260813 IS - 2413-7170 (Electronic) IS - 1029-1857 (Print) IS - 1029-1857 (Linking) VI - 36 IP - 1 DP - 2026 Jan TI - Clinical Risk Index for Babies Scoring System in Prediction of Mortality in Premature Babies: A Prospective Study at in Mumbai. PG - 55-59 LID - 10.4314/ejhs.v36i1.9 [doi] AB - BACKGROUND: The Clinical Risk Index for Babies II (CRIB II) is a validated scoring system for predicting early mortality risk among low birth weight (LBW) preterm neonates. However, its routine use remains limited in many developing countries. This study aimed to evaluate the effectiveness of the CRIB II score in predicting neonatal mortality among LBW infants admitted to a tertiary care Neonatal Intensive Care Unit (NICU). METHODS: This prospective cohort study included 140 preterm neonates (gestational age 23-32 weeks) admitted to the NICU within 24 hours of birth. Baseline demographic variables, clinical characteristics, and CRIB II scores were recorded Neonatal outcomes were followed until discharge or death. Diagnostic performance was assessed using sensitivity, specificity, predictive values, accuracy, and receiver operating characteristic (ROC) curve analysis. RESULTS: There was a slight male predominance (51%). The mean birth weight was 1550.97 +/- 253.58 g, and the mean gestational age was 30.42 +/- 2.23 weeks. Overall neonatal mortality was 32.85%. Mortality increased progressively with higher CRIB II scores: 0% in level I, 3.84% in level II, 64.70% in level III, and 100% in level IV. The CRIB II score demonstrated excellent predictive performance with a sensitivity of 84.78%, specificity of 90.42%, and diagnostic accuracy of 88.57%. CONCLUSION: The CRIB II score is a reliable and effective tool for early prediction of neonatal mortality in LBW preterm infants and should be considered for routine risk stratification in NICU settings. CI - (c) 2026 Nilima N., et al. FAU - Narkhede, Nilima AU - Narkhede N AD - Department of Pediatrics, Bharatratna Dr Babasaheb Ambedkar Municipal General Hospital, Kandivali(w), Mumbai. FAU - Weling, Rajaram AU - Weling R AD - Department of Pediatrics, Bharatratna Dr Babasaheb Ambedkar Municipal General Hospital, Kandivali(w), Mumbai. FAU - Pradhan, Reshma AU - Pradhan R AD - Department of Pediatrics, Bharatratna Dr Babasaheb Ambedkar Municipal General Hospital, Kandivali(w), Mumbai. LA - eng PT - Journal Article PL - Ethiopia TA - Ethiop J Health Sci JT - Ethiopian journal of health sciences JID - 101224773 SB - IM MH - Humans MH - Infant, Newborn MH - Prospective Studies MH - Female MH - Male MH - *Infant Mortality MH - *Infant, Premature MH - Intensive Care Units, Neonatal MH - Risk Assessment/methods MH - Infant, Low Birth Weight MH - Gestational Age MH - Infant MH - Sensitivity and Specificity MH - ROC Curve MH - Predictive Value of Tests MH - India/epidemiology MH - Birth Weight PMC - PMC13103286 OTO - NOTNLM OT - CRIB II score OT - NICU OT - low birth weight OT - neonatal mortality OT - preterm infants COIS- Competing Interests: The authors declare that this manuscript was approved by all authors in its form and that no competing interest exists. EDAT- 2026/04/27 12:34 MHDA- 2026/04/27 12:35 PMCR- 2026/01/01 CRDT- 2026/04/27 06:57 PHST- 2025/09/09 00:00 [received] PHST- 2026/12/23 00:00 [accepted] PHST- 2026/04/27 12:35 [medline] PHST- 2026/04/27 12:34 [pubmed] PHST- 2026/04/27 06:57 [entrez] PHST- 2026/01/01 00:00 [pmc-release] AID - jEJHS.v36.i1.pg55 [pii] AID - 10.4314/ejhs.v36i1.9 [doi] PST - ppublish SO - Ethiop J Health Sci. 2026 Jan;36(1):55-59. doi: 10.4314/ejhs.v36i1.9. PMID- 42039122 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Neutrophil count and urinary glucose as early predictors of gestational diabetes mellitus in nulliparous women of advanced maternal age: a retrospective cohort study. PG - 1791755 LID - 10.3389/fendo.2026.1791755 [doi] LID - 1791755 AB - BACKGROUND: Gestational diabetes mellitus (GDM) poses significant risks, particularly for nulliparous women of advanced maternal age (AMA >/=35 years), a growing demographic due to delayed childbirth. However, effective early-pregnancy prediction tools tailored for this high-risk subgroup are lacking. This study aimed to identify readily available early biomarkers for GDM risk stratification in AMA nulliparous women. METHODS: This retrospective cohort study analyzed 354 AMA nulliparous women (140 GDM, 214 non-GDM). GDM was diagnosed by a 75g oral glucose tolerance test at 24-28 weeks using IADPSG criteria (fasting >/=5.1 mmol/L, 1-h >/=10.0 mmol/L, 2-h >/=8.5 mmol/L). Clinical and laboratory data at 10-13 gestational weeks were compared. Multivariate logistic regression identified independent risk factors. RESULTS: The GDM group had significantly higher body mass index (BMI), fasting blood glucose (FBG), white blood cell (WBC) count, neutrophil count (NEU), and urinary glucose (U-GLU) positivity (P< 0.05). Assisted reproductive technology (ART) use did not differ significantly in univariate analysis (P = 0.083). Multivariable analysis identified U-GLU positivity (adjusted odds ratio [aOR] = 7.91; 95% CI: 2.67-23.46), elevated FBG (aOR = 2.23 per mmol/L; 95% CI: 1.13-4.38), elevated NEU (aOR = 1.21 per 10(9)/L; 95% CI: 1.05-1.40), elevated WBC (aOR = 1.15 per 10(9)/L; 95% CI: 1.01-1.30), and ART use (aOR = 1.63; 95% CI: 1.02-2.59) as independent risk factors for GDM. The multivariable model achieved an AUC of 0.70 (95% CI 0.65 - 0.76), with sensitivity of 57.1% and specificity of 76.2% at the optimal cutoff. CONCLUSIONS: In this single-center retrospective cohort of AMA nulliparous women, early-pregnancy urinary glucose positivity, elevated fasting blood glucose, neutrophilia, leukocytosis, and the use of assisted reproductive technology were independently associated with an increased risk of GDM, with urinary glucose showing the strongest association. These findings suggest that a tiered screening strategy incorporating these readily available biomarkers might be explored for early risk stratification between 10-13 weeks' gestation. Their clinical utility requires prospective validation in larger, multicenter cohorts. CI - Copyright (c) 2026 Zhao, Bi, Bei, Huang, He and Yuan. FAU - Zhao, Kai Sun AU - Zhao KS AD - Department of Obstetrics, The Third Affiliated Hospital of Guangxi Medical University, the Second Nanning People's Hospital, Nanning, Guangxi Zhuang Autonomous Region, China. AD - China-ASEAN Medical Research Center, China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China. FAU - Bi, Jie Cheng AU - Bi JC AD - Department of Obstetrics, The Third Affiliated Hospital of Guangxi Medical University, the Second Nanning People's Hospital, Nanning, Guangxi Zhuang Autonomous Region, China. AD - China-ASEAN Medical Research Center, China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China. FAU - Bei, Ni AU - Bei N AD - Department of Obstetrics, The Third Affiliated Hospital of Guangxi Medical University, the Second Nanning People's Hospital, Nanning, Guangxi Zhuang Autonomous Region, China. AD - China-ASEAN Medical Research Center, China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China. FAU - Huang, Jian Chun AU - Huang JC AD - Department of Obstetrics, The Third Affiliated Hospital of Guangxi Medical University, the Second Nanning People's Hospital, Nanning, Guangxi Zhuang Autonomous Region, China. AD - China-ASEAN Medical Research Center, China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China. FAU - He, Mei Rong AU - He MR AD - Department of Obstetrics, The Third Affiliated Hospital of Guangxi Medical University, the Second Nanning People's Hospital, Nanning, Guangxi Zhuang Autonomous Region, China. AD - China-ASEAN Medical Research Center, China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China. FAU - Yuan, Chun Lan AU - Yuan CL AD - Department of Obstetrics, The Third Affiliated Hospital of Guangxi Medical University, the Second Nanning People's Hospital, Nanning, Guangxi Zhuang Autonomous Region, China. AD - China-ASEAN Medical Research Center, China Hospital Development Institute, Shanghai Jiao Tong University, Shanghai, China. LA - eng PT - Journal Article DEP - 20260410 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) RN - IY9XDZ35W2 (Glucose) SB - IM MH - Humans MH - Female MH - *Diabetes, Gestational/diagnosis/urine/blood MH - Retrospective Studies MH - Pregnancy MH - Advanced Maternal Age MH - Adult MH - *Neutrophils/pathology MH - Biomarkers/urine MH - Leukocyte Count MH - Parity MH - Glucose Tolerance Test MH - Risk Factors MH - Blood Glucose/analysis MH - *Glycosuria/urine/diagnosis MH - *Glucose/metabolism PMC - PMC13106421 OTO - NOTNLM OT - advanced maternal age OT - assisted reproductive technology OT - first trimester OT - gestational diabetes mellitus OT - glycosuria OT - neutrophils OT - prediction COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/27 12:34 MHDA- 2026/04/27 12:35 PMCR- 2026/04/10 CRDT- 2026/04/27 06:56 PHST- 2026/01/20 00:00 [received] PHST- 2026/03/05 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/04/27 12:35 [medline] PHST- 2026/04/27 12:34 [pubmed] PHST- 2026/04/27 06:56 [entrez] PHST- 2026/04/10 00:00 [pmc-release] AID - 10.3389/fendo.2026.1791755 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Apr 10;17:1791755. doi: 10.3389/fendo.2026.1791755. eCollection 2026. PMID- 42038447 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260427 LR - 20260813 IS - 1179-1608 (Print) IS - 1179-1608 (Electronic) IS - 1179-1608 (Linking) VI - 18 DP - 2026 TI - Predictive Value of Neck-to-Height Ratio in Children with Moderate/Severe Obstructive Sleep Apnea: A Retrospective Cross-Sectional Study. PG - 588036 LID - 10.2147/NSS.S588036 [doi] LID - 588036 AB - OBJECTIVE: Obstructive Sleep Apnea (OSA) is a common sleep-disordered breathing condition in children. Moderate/severe OSA can lead to a series of complications, including growth restriction and neurocognitive impairment, severely impacting children's physical and mental health. The gold standard for diagnosing OSA is polysomnography (PSG). Given the limitations of PSG in large-scale screening and the insufficient accuracy and compliance of existing screening tools, exploring simple and reliable screening tools for moderate/severe OSA holds significant clinical importance. This study aims to systematically compare the predictive efficacy of neck-to-height ratio (NHR), waist-to-height ratio (WHtR), hip-to-height ratio (HHR), and BMI Z-score for moderate/severe pediatric OSA, providing more accurate and convenient indicators for clinical screening. METHODS: We retrospectively analyzed data from 685 children aged 3-16 years who underwent PSG. Using age, gender, tonsil size, and adenoid size as covariates, receiver operating characteristic (ROC) analysis was used to assess the discriminatory ability of NHR, WHtR, HHR, and BMI Z-score in the overall cohort and within age and gender subgroups. RESULTS: NHR demonstrated the highest predictive efficacy in the overall cohort (AUC=0.781), significantly outperforming other indices. Subgroup analysis revealed that NHR maintained excellent predictive performance in children above 10 years, with AUC values of 0.777 in boys and 0.913 in girls. CONCLUSION: The NHR may serve as a useful adjunctive screening tool for moderate/severe OSA in children above 10 years, showing moderate predictive value and outperforming traditional indices such as WHtR, HHR, and BMI Z-score. CI - (c) 2026 Liu et al. FAU - Liu, Tianxu AU - Liu T AD - Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, People's Republic of China. FAU - Wang, Xiaoyi AU - Wang X AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. FAU - Hu, Wen AU - Hu W AD - Department of Otolaryngology, Head and Neck Surgery, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, People's Republic of China. FAU - Kong, Yaru AU - Kong Y AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. FAU - Wan, Yiling AU - Wan Y AUID- ORCID: 0000-0001-8260-3048 AD - Capital Institute of Pediatrics, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China. FAU - Zhan, Xiaojun AU - Zhan X AD - Department of Otolaryngology, Head and Neck Surgery, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, People's Republic of China. FAU - Tai, Jun AU - Tai J AD - Department of Otolaryngology, Head and Neck Surgery, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, People's Republic of China. LA - eng PT - Journal Article DEP - 20260421 PL - New Zealand TA - Nat Sci Sleep JT - Nature and science of sleep JID - 101537767 PMC - PMC13109984 OTO - NOTNLM OT - anthropometric indices OT - children OT - neck-to-height ratio OT - obstructive sleep apnea OT - polysomnography COIS- The authors report no conflicts of interest in this work. EDAT- 2026/04/27 12:35 MHDA- 2026/04/27 12:36 PMCR- 2026/04/21 CRDT- 2026/04/27 06:51 PHST- 2025/12/12 00:00 [received] PHST- 2026/04/05 00:00 [accepted] PHST- 2026/04/27 12:36 [medline] PHST- 2026/04/27 12:35 [pubmed] PHST- 2026/04/27 06:51 [entrez] PHST- 2026/04/21 00:00 [pmc-release] AID - 588036 [pii] AID - 10.2147/NSS.S588036 [doi] PST - epublish SO - Nat Sci Sleep. 2026 Apr 21;18:588036. doi: 10.2147/NSS.S588036. eCollection 2026. PMID- 42038223 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260427 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Gastrointestinal dysfunction in patients with Mowat-Wilson syndrome is associated with feeding difficulties and altered plasma neurotransmitters. PG - 1751767 LID - 10.3389/fped.2026.1751767 [doi] LID - 1751767 AB - BACKGROUND: Intestinal dysfunction is prevalent in children with Mowat-Wilson syndrome (MWS), yet its underlying mechanisms remain unclear. This study aimed to characterize intestinal symptoms, feeding patterns, and fasting plasma neurotransmitter profiles in patients with MWS, and to explore their potential relationships. METHODS: Three complementary assessments were conducted, including a questionnaire assessing defecation difficulties and stool characteristics; a structured questionnaire assessing feeding difficulties, caregiver-reported dietary composition (including the proportion of meat), and complementary feeding practices; and targeted fasting plasma neurotransmitter profiling using UPLC-TQ-MS. RESULTS: Among 35 patients with MWS, 86% had intestinal symptoms, including constipation (69%) and Hirschsprung disease (17%). In the feeding/diet analysis, 44.4% (4/9) of patients with MWS reported feeding difficulties. Compared with age-matched healthy controls (n = 10), patients with MWS (n = 9) had a significantly lower proportion of meat and delayed introduction of meat-based complementary foods (10.5 months vs. 7.9 months). In the plasma analysis, patients with MWS (n = 6) exhibited significantly reduced plasma levels of serotonin and taurine, alongside elevated levels of GABA and dopamine, compared with age-matched healthy controls (n = 10). CONCLUSION: These findings confirm the high prevalence of constipation-predominant intestinal dysfunction in patients with MWS. Collectively, our findings support further investigation of associations among feeding difficulties, a lower proportion of meat in dietary composition, and an altered fasting plasma neurotransmitter profile (including lower serotonin in a small subset), which may be relevant to gut dysmotility in patients with MWS. This diet-neurotransmitter axis offers a working model for understanding intestinal dysfunction in patients with MWS, yet direct quantification of dietary and circulating tryptophan in future studies is needed to validate this pathway. CI - (c) 2026 Liu, Wu, Zhou, Zhang, Xiao, Li, Li, Jiang and Wu. FAU - Liu, Lingya AU - Liu L AD - Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, China. FAU - Wu, Lihua AU - Wu L AD - Department of Medical Genetics, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Zhou, Ruijie AU - Zhou R AD - Department of General Surgery, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Zhang, Zhen AU - Zhang Z AD - Department of General Surgery, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Xiao, Ping AU - Xiao P AD - Department of Pathology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Li, Bo AU - Li B AD - Translational Medicine Program, The Hospital for Sick Children, Toronto, ON, Canada. FAU - Li, Qi AU - Li Q AD - Department of General Surgery, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Jiang, Qian AU - Jiang Q AD - Department of Medical Genetics, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Wu, Jianxin AU - Wu J AD - Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing, China. LA - eng PT - Journal Article DEP - 20260410 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13106388 OTO - NOTNLM OT - Mowat-Wilson syndrome OT - feeding difficulties OT - intestinal dysfunction OT - neurotransmitter OT - serotonin COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/27 12:34 MHDA- 2026/04/27 12:35 PMCR- 2026/04/10 CRDT- 2026/04/27 06:49 PHST- 2025/11/24 00:00 [received] PHST- 2026/03/23 00:00 [revised] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/04/27 12:35 [medline] PHST- 2026/04/27 12:34 [pubmed] PHST- 2026/04/27 06:49 [entrez] PHST- 2026/04/10 00:00 [pmc-release] AID - 10.3389/fped.2026.1751767 [doi] PST - epublish SO - Front Pediatr. 2026 Apr 10;14:1751767. doi: 10.3389/fped.2026.1751767. eCollection 2026. PMID- 42037831 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260427 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 3 DP - 2026 Mar TI - Prevalence of Malnutrition and Its Associated Factors Among Children in the 5-15 Years Age Group: A Community-Based Cross-Sectional Study From Selected Rural Areas of Khordha District, Odisha. PG - e105874 LID - 10.7759/cureus.105874 [doi] LID - e105874 AB - Introduction Malnutrition is one of the most common causes of morbidity and mortality among children and adolescents throughout the world. Various factors, including socio-demographic characteristics, poor feeding practices, and childhood diseases, contribute to malnutrition. This study aimed to assess the prevalence of malnutrition and its associated factors among 5 to 15-year-old children of selected rural areas of Khordha District, Odisha. Method A community-based descriptive cross-sectional study was conducted among children in Simlipatana and Kujjimahal villages of Khordha district, Odisha. All eligible children (5 to 15 years of age) residing in both study areas were included in the sampling frame. A total of 380 participants were enrolled in the study, based on a 45% prevalence, using simple random sampling. Data were collected using participants' socio-demographic characteristics, anthropometric measurements, the IAP growth chart app, and a validated questionnaire to assess factors associated with malnutrition. The data were analysed using SPSS software, version 26.0 (IBM Corp., Armonk, NY). Results The study findings revealed that the prevalence of malnutrition was 41.3%, with 13.9% underweight, 12.9% overweight, 5.3% obese, and varying degrees of stunting. Among malnourished children, 56.32% were female, and nearly half (43.67%) were male. Malnutrition was significantly associated with sociodemographic factors like family type, income, parental education, and hygiene practices. Dietary intake patterns, such as consumption of milk, pulses, and fruits. Logistic regression analysis revealed that four key significant factors were associated with malnutrition of children, including large family size (odds ratio (OR) = 2.019, P < 0.003), poor hygiene (OR = 2.082, P < 0.006), lack of parental education (OR = 2.045, P < 0.003), and inadequate dietary intake (OR) = 2.115, P < 0.011). Conclusions The overall prevalence of malnutrition was 41.3%, and it decreased with age. Dietary patterns and sociodemographic profiles are significantly associated with the development of malnutrition. CI - Copyright (c) 2026, Singh et al. FAU - Singh, Rekha AU - Singh R AD - Pediatric Nursing, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND. FAU - Nayak, Geetarani AU - Nayak G AD - Pediatric Nursing, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND. FAU - Satapathy, Amit AU - Satapathy A AD - Pediatrics, All India Institute of Medical Sciences, Bhubaneswar, Bhubaneswar, IND. LA - eng PT - Journal Article DEP - 20260326 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13110084 OTO - NOTNLM OT - associated factor OT - children and adolescent OT - malnutrition OT - prevalence OT - stunting and undernutrition COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee, All India of Institute of Medical Sciences, Bhubaneshwar issued approval IEC/AIIMS BBSR/Nursing/2019-20/35. Approved. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/04/27 12:34 MHDA- 2026/04/27 12:35 PMCR- 2026/03/26 CRDT- 2026/04/27 06:46 PHST- 2026/03/25 00:00 [accepted] PHST- 2026/04/27 12:35 [medline] PHST- 2026/04/27 12:34 [pubmed] PHST- 2026/04/27 06:46 [entrez] PHST- 2026/03/26 00:00 [pmc-release] AID - 10.7759/cureus.105874 [doi] PST - epublish SO - Cureus. 2026 Mar 26;18(3):e105874. doi: 10.7759/cureus.105874. eCollection 2026 Mar. PMID- 42037786 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260427 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 3 DP - 2026 Mar TI - Reassessing the Application of the Haller Index as a Surgical Indicator for Pectus Excavatum. PG - e105884 LID - 10.7759/cureus.105884 [doi] LID - e105884 AB - Pectus excavatum, or "funnel chest," is the most common congenital chest wall deformity, characterized by posterior depression of the sternum and adjacent costal cartilages. Although frequently identified in childhood, the deformity often progresses during adolescence and may lead to exercise intolerance, respiratory symptoms, and psychosocial distress. Traditionally, surgical indications have been guided by the Haller index, a radiographic metric derived from chest computed tomography (CT) scans, although its reliability in predicting functional compromise remains debated. This retrospective study evaluated 41 Hispanic pediatric patients with pectus excavatum (mean age 14.1 years), of whom 36 of 41 (88%) were male, who were seen at Puerto Rico Children's Hospital between 2015 and 2021. Spirometry values, including forced vital capacity (FVC) and forced expiratory volume in one second (FEV(1)), were compared across Haller index categories (<3.25 vs >/= 3.25). No statistically significant correlation was found between the Haller index and individual spirometry parameters, consistent with weak Pearson correlation coefficients (r = -0.26 for FVC and r = -0.14 for FEV(1)). Receiver operating characteristic (ROC) analysis demonstrated limited ability of the Haller index to identify reduced FVC (AUC = 0.63). These findings suggest that the Haller index alone is insufficient as a standalone surgical indicator for pectus excavatum. A comprehensive evaluation incorporating dynamic cardiopulmonary assessment, psychological considerations, and refined imaging tools such as the correction index may better inform surgical decision-making. CI - Copyright (c) 2026, Calderin Barreto et al. FAU - Calderin Barreto, Bryan J AU - Calderin Barreto BJ AD - Pediatrics, Puerto Rico Children's Hospital, Bayamon, PRI. FAU - Salcedo Martir, Glorimar AU - Salcedo Martir G AD - Pediatrics, Puerto Rico Children's Hospital, Bayamon, PRI. FAU - Nieves Tirado, Maria L AU - Nieves Tirado ML AD - Pediatrics, Puerto Rico Children's Hospital, Bayamon, PRI. FAU - Iriarte, Ivan R AU - Iriarte IR AD - Family Medicine, Mayaguez Medical Center, Mayaguez, PRI. FAU - Ramirez-Lluch, Norman AU - Ramirez-Lluch N AD - Pediatric Orthopedic Surgery, Mayaguez Medical Center, Mayaguez, PRI. FAU - Ortiz Justiniano, Victor N AU - Ortiz Justiniano VN AD - Pediatric Surgery, Auxilio Mutuo Pediatrico, San Juan, PRI. LA - eng PT - Journal Article DEP - 20260326 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13109901 OTO - NOTNLM OT - chest wall deformity OT - haller index OT - hispanic population OT - pectus excavatum OT - pulmonary function tests OT - surgical candidacy COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Ponce Research Institute issued approval 2012050756. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/04/27 12:33 MHDA- 2026/04/27 12:34 PMCR- 2026/03/26 CRDT- 2026/04/27 06:46 PHST- 2026/03/26 00:00 [accepted] PHST- 2026/04/27 12:34 [medline] PHST- 2026/04/27 12:33 [pubmed] PHST- 2026/04/27 06:46 [entrez] PHST- 2026/03/26 00:00 [pmc-release] AID - 10.7759/cureus.105884 [doi] PST - epublish SO - Cureus. 2026 Mar 26;18(3):e105884. doi: 10.7759/cureus.105884. eCollection 2026 Mar. PMID- 42037051 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260813 IS - 1099-0968 (Electronic) IS - 1072-4133 (Print) IS - 1072-4133 (Linking) VI - 34 IP - 5 DP - 2026 Sep TI - Associations Between Avoidant/Restrictive Food Intake Disorder Dimensions and Obsessive-Compulsive Symptomatology. PG - 1327-1335 LID - 10.1002/erv.70122 [doi] AB - OBJECTIVE: Although obsessive-compulsive disorder (OCD) commonly co-occurs with anorexia nervosa and bulimia nervosa, less is known about its relationship with avoidant/restrictive food intake disorder (ARFID) dimensions. Whether associations between ARFID dimensions and OCD differ by sex is also unclear. We examined associations between ARFID dimensions and OCD symptoms by sex, accounting for depression and anxiety. METHODS: Data from 3120 participants ages 15+ in the ARFID Genes and Environment (ARFID-GEN) study were analyzed. ARFID dimensions (i.e., sensory sensitivity; low appetite/lack of interest in food; and fear of aversive consequences), OCD symptoms, anxiety, and depression were assessed using validated self-report measures. We evaluated associations between ARFID dimensions and OCD symptoms using general linear models, adjusting for depression and anxiety. RESULTS: ARFID dimensions were significantly associated with OCD symptoms. After adjusting for depression and anxiety, these associations were attenuated but remained significant for all ARFID dimensions. Associations between ARFID dimensions and OCD symptoms varied by sex. CONCLUSION: The relation between ARFID symptomatology and OCD warrants further exploration across the developmental spectrum in which ARFID appears. Clinically, bidirectional screening may improve diagnostic clarity and be informative to tailor interventions appropriately. TRIAL REGISTRATION: ARFID-GEN is registered in clinicaltrials.gov (NCT05605067). CI - (c) 2026 The Author(s). European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd. FAU - Aguilar, Mariana Valdez AU - Aguilar MV AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Giulumian, Gabriela K AU - Giulumian GK AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Rodriguez, Isabel AU - Rodriguez I AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Baker, Jessica H AU - Baker JH AUID- ORCID: 0000-0002-3997-2398 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Surti, Preina P AU - Surti PP AD - Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Dinkler, Lisa AU - Dinkler L AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Guintivano, Jerry AU - Guintivano J AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Johnson, Jessica S AU - Johnson JS AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - MacDermod, Casey M AU - MacDermod CM AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Ortiz, Shelby N AU - Ortiz SN AUID- ORCID: 0000-0001-8088-8254 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Pisetsky, Emily M AU - Pisetsky EM AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - White, Jennifer P AU - White JP AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Micali, Nadia AU - Micali N AUID- ORCID: 0000-0001-5571-2273 AD - Center for Eating and Feeding Disorders Research, Mental Health Center Ballerup, Copenhagen University Hospital-Mental Health Services CPH, Copenhagen, Denmark. AD - Great Ormond Street Institute of Child Health, University College London, London, UK. AD - Institute for Biological Psychiatry, Mental Health Centre Sct Hans, Copenhagen University Hospital-Mental Health Services, Copenhagen, Denmark. FAU - Bulik, Cynthia M AU - Bulik CM AUID- ORCID: 0000-0001-7772-3264 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Thornton, Laura M AU - Thornton LM AUID- ORCID: 0000-0001-9384-7988 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Wu, Ya-Ke AU - Wu YK AUID- ORCID: 0000-0001-8990-3449 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - School of Nursing, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. LA - eng SI - ClinicalTrials.gov/NCT05605067 GR - R56MH129437/MH/NIMH NIH HHS/United States GR - Office of Community Development/ GR - R56MH129437/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20260426 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 SB - IM MH - Humans MH - *Obsessive-Compulsive Disorder/psychology/complications MH - Female MH - Male MH - *Avoidant Restrictive Food Intake Disorder/psychology MH - Adult MH - Adolescent MH - Anxiety/psychology MH - Depression/psychology MH - Young Adult MH - Middle Aged PMC - PMC13432419 OTO - NOTNLM OT - anxiety OT - depression OT - eating disorders OT - feeding disorders OT - obsessive-compulsive symptomatology COIS- Dr. Bulik receives royalties from Pearson Education Inc. Dr. Dinkler has received personal fees from Baxter Medical AB and Fresenius Kabi AB outside the submitted work. Other authors declare no competing interests. EDAT- 2026/04/27 06:31 MHDA- 2026/08/03 18:37 PMCR- 2026/08/03 CRDT- 2026/04/27 02:52 PHST- 2025/11/18 00:00 [revised] PHST- 2025/05/09 00:00 [received] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/08/03 18:37 [medline] PHST- 2026/04/27 06:31 [pubmed] PHST- 2026/04/27 02:52 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - ERV70122 [pii] AID - 10.1002/erv.70122 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2026 Sep;34(5):1327-1335. doi: 10.1002/erv.70122. Epub 2026 Apr 26. PMID- 42036939 OWN - NLM STAT- Publisher LR - 20260427 IS - 1552-5732 (Electronic) IS - 0890-3344 (Linking) DP - 2026 Apr 26 TI - Breastfeeding Knowledge, Attitudes, and Intentions Among Female Human Nutrition and Dietetics Students in Ibadan, Nigeria. PG - 8903344261434528 LID - 10.1177/08903344261434528 [doi] AB - BACKGROUND: Breastfeeding is essential for a child's growth and development, and beneficial for both mother and child. Nutritionists are at the forefront of promoting exclusive breastfeeding and are expected to have good knowledge, attitudes, and intentions towards breastfeeding. However, there is no information on the breastfeeding knowledge, attitudes, and intentions among female nutrition and dietetics students. RESEARCH AIM: This study aimed to assess the breastfeeding knowledge, attitudes, and intentions of human nutrition and dietetics students in Nigeria. METHODS: A descriptive cross-sectional study was conducted among 154 proportionately sampled Human Nutrition and Dietetics students using a validated, structured, web-based, self-administered questionnaire to obtain information. The questionnaire was developed based on previous literature from which questions and scales were constructed. Each variable (knowledge, attitude, and intention) was scored and categorized. The data were analyzed using SPSS (Version 26). RESULTS: The mean age of the students was 20.97 +/- 2.9 years. About 80% of the students indicated that breastfeeding should be initiated within 1 hour of birth and a correct definition of exclusive breastfeeding was given by 76.3% of the students. Of all the students, 89.9% had good breastfeeding knowledge, 93.5% students had a positive attitude towards breastfeeding, while about three out of 10 students had poor breastfeeding intention. Almost all (92.4%) students who had a positive attitude towards breastfeeding had good knowledge of breastfeeding (X(2) = 16.3, p = 0.000). CONCLUSION: This study revealed that the students possessed good breastfeeding knowledge and attitudes towards breastfeeding. This shows an increased likelihood of an increased rate of breastfeeding practices in the future. FAU - Bodunde, Ifeoluwa Omolara AU - Bodunde IO AUID- ORCID: 0000-0002-1454-2914 AD - Department of Human Nutrition and Dietetics, Lead City University, Ibadan, Nigeria. FAU - Adebayo, Mariam Oyindamola AU - Adebayo MO AD - Department of Human Nutrition and Dietetics, Lead City University, Ibadan, Nigeria. FAU - Abiola, Oluwamayowa Fortune AU - Abiola OF AD - Department of Human Nutrition and Dietetics, Lead City University, Ibadan, Nigeria. FAU - Olatunji, Tobi Janet AU - Olatunji TJ AD - Department of Nutrition and Dietetics, Moshood Abiola Polytechnic, Abeokuta, Nigeria. LA - eng PT - Journal Article DEP - 20260426 PL - United States TA - J Hum Lact JT - Journal of human lactation : official journal of International Lactation Consultant Association JID - 8709498 SB - IM OTO - NOTNLM OT - attitude OT - breastfeeding OT - intention OT - knowledge OT - nutrition students EDAT- 2026/04/27 06:32 MHDA- 2026/04/27 06:32 CRDT- 2026/04/27 01:33 PHST- 2026/04/27 06:32 [medline] PHST- 2026/04/27 06:32 [pubmed] PHST- 2026/04/27 01:33 [entrez] AID - 10.1177/08903344261434528 [doi] PST - aheadofprint SO - J Hum Lact. 2026 Apr 26:8903344261434528. doi: 10.1177/08903344261434528. PMID- 42036681 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260813 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 45 IP - 1 DP - 2026 Apr 26 TI - Predicting fast food avoidance behavior among male adolescents: a structural equation modeling approach to the theory of planned behavior. LID - 10.1186/s41043-026-01320-y [doi] LID - 155 AB - BACKGROUND: Fast food consumption is a growing public health concern, particularly among adolescents, due to its association with obesity and chronic diseases. Understanding the behavioral determinants of fast-food avoidance can inform the design of effective interventions targeting male adolescents. OBJECTIVE: This study aimed to investigate the determinants of fast-food avoidance behaviors among male high school students in Shiraz, Iran, using the Theory of Planned Behavior (TPB) and Structural Equation Modeling (SEM). METHODS: A cross-sectional study was conducted among 862 male students in grades 1 and 2 of high school in Shiraz in 2025. A multi-stage sampling strategy was applied, whereby 16 high schools were randomly selected from four educational districts. Within selected schools, classes and students were recruited using a convenience-based approach, and all eligible students present in the selected classes were invited to participate. Data were collected using a demographic questionnaire and a validated TPB-based instrument assessing knowledge, attitude, subjective norms, perceived behavioral control (PBC), behavioral intention, and fast-food avoidance behavior. Data analysis was performed using JAMOVI (v2.5.6), and SEM was employed to test the hypothesized TPB model. RESULTS: The final TPB model demonstrated excellent fit indices (chi(2)/df = 2.04, CFI = 0.94, RMSEA = 0.05). Attitude (beta = 0.58), subjective norms (beta = 0.34), and PBC (beta = 0.26) significantly predicted behavioral intention (p < .001), which in turn strongly predicted fast-food avoidance behavior (beta = 0.49, p < .001). PBC also had a direct effect on behavior (beta = 0.31). Knowledge exerted an indirect effect on behavior through attitude and intention. Demographic variables, including parental education, household income, and maternal employment, were associated with TPB constructs. CONCLUSION: Fast-food avoidance behaviors among male adolescents are primarily influenced by motivational and control beliefs. From a practical and policy perspective, school-based nutrition education programs and adolescent health policies should prioritize strengthening positive attitudes, enhancing perceived behavioral control, and reinforcing supportive social norms to promote healthier dietary behaviors and reduce fast-food consumption among adolescents. CI - (c) 2026. The Author(s). FAU - Ansarifard, Leila AU - Ansarifard L AD - Department of Nursing, Firooabad Higher Education Complex for Health, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Dahi, Ali Al AU - Dahi AA AD - Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Behzadinezhad, Sarayel AU - Behzadinezhad S AD - Department of Nursing, Firooabad Higher Education Complex for Health, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Hamedi, Andishe AU - Hamedi A AUID- ORCID: 0000-0003-4484-2915 AD - Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Asadollahi, Abdolrahim AU - Asadollahi A AUID- ORCID: 0000-0003-2265-5641 AD - Department of Gerontology, School of Health, Shiraz University of Medical Sciences, Razi Ave, Shiraz, Iran. FAU - Golab, Farzaneh Ghaleh AU - Golab FG AD - Department of Healthcare Management, School of Management and Medical Informatics, Shiraz University of Medical Sciences, Shiraz, Iran. FAU - Sendall, Marguerite Claire AU - Sendall MC AD - Department of Environmental and Public Health, Abu Dhabi University, Abu Dhabi, United Arab Emirates. FAU - Jeihooni, Ali Khani AU - Jeihooni AK AD - Department of Public Health, Nutrition Research Center, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran. khani_1512@yahoo.com. LA - eng PT - Journal Article DEP - 20260426 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Humans MH - Male MH - Theory of Planned Behavior MH - Adolescent MH - Cross-Sectional Studies MH - Iran MH - *Fast Foods MH - *Adolescent Behavior/psychology MH - Latent Class Analysis MH - Health Knowledge, Attitudes, Practice MH - Surveys and Questionnaires MH - Intention MH - *Feeding Behavior/psychology MH - Students/psychology PMC - PMC13289231 OTO - NOTNLM OT - Adolescent OT - Dietary Behaviors OT - Fast Food Avoidance OT - Fast Foods OT - Feeding Behavior OT - Male OT - Male Adolescents OT - Models OT - Psychological OT - Structural Equation Modeling OT - Surveys and Questionnaires OT - Theory of Planned Behavior COIS- Declarations. Ethics approval and consent to participate: This study protocol was approved by the ethics committee of Shiraz University of Medical Sciences. All study participants provided written informed consent. Informed consent was obtained from a parent and/or legal guardian of all the study participants as the subjects are under 16 years old. The ethics committee approved the procedure for verbal consent since the study is observational and respected the code of ethics as stated in the declarations of Helsinki. Consent for publication: None. Competing interests: The authors declare no competing interests. EDAT- 2026/04/27 00:30 MHDA- 2026/06/23 18:34 PMCR- 2026/04/26 CRDT- 2026/04/26 23:48 PHST- 2025/12/15 00:00 [received] PHST- 2026/04/02 00:00 [accepted] PHST- 2026/06/23 18:34 [medline] PHST- 2026/04/27 00:30 [pubmed] PHST- 2026/04/26 23:48 [entrez] PHST- 2026/04/26 00:00 [pmc-release] AID - 10.1186/s41043-026-01320-y [pii] AID - 1320 [pii] AID - 10.1186/s41043-026-01320-y [doi] PST - epublish SO - J Health Popul Nutr. 2026 Apr 26;45(1):155. doi: 10.1186/s41043-026-01320-y. PMID- 42035698 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 1873-5347 (Electronic) IS - 0277-9536 (Linking) VI - 400 DP - 2026 Jul TI - Using a theory-based approach to evaluate a physical activity promotion intervention for youth with intellectual disabilities. PG - 119303 LID - S0277-9536(26)00379-5 [pii] LID - 10.1016/j.socscimed.2026.119303 [doi] AB - Youth with intellectual disabilities are less physically active than their typically developing peers. Although interventions to promote physical activity (PA) exist, their effectiveness remains limited and poorly understood. This study introduces a theory-based single-case evaluation approach, using a co-created dyadic PA intervention as the empirical setting to examine causal mechanisms and contextual conditions underlying intervention (in)effectiveness at the individual level. Seven young adults (M(age) = 18.9 +/- 1.7 years) with mild to moderate intellectual disabilities participated in a single-case (A1-B-A2) evaluation with an average 8-week intervention phase. PA was measured using accelerometers and analysed through visual analyses and overlap indices. An initial program theory outlining hypothesised causal steps and contextual conditions was developed before analysis. Biweekly interviews with participants and post-intervention interviews with buddies and caregivers (n = 78) were analysed to refine the program theory. Quantitative analyses indicated increases in total PA in two of seven cases, while three lacked sufficient accelerometer data. The refined program theory outlined three overarching principles (goal interaction, sense of belonging, caregiver support) and six causal steps from 'buddy compatibility' to 'activity exploration' and 'integration'. Across this causal chain, 25 support factors, 29 derailers, and 26 safeguards were identified. The analysis revealed distinct case-level constellations explaining heterogeneous outcomes. Beyond mixed effects on PA, this study shows how a theory-based single-case evaluation can generate mechanistic and context-sensitive insights in heterogeneous populations. Future research should build on these insights to further optimise the intervention and examine feasibility in larger samples. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Maenhout, Laura AU - Maenhout L AD - Department of Movement and Sports Sciences, Ghent University, Belgium; Research Foundation Flanders (FWO), Brussels, Belgium. Electronic address: Laura.Maenhout@UGent.be. FAU - Compernolle, Sofie AU - Compernolle S AD - Department of Movement and Sports Sciences, Ghent University, Belgium; Research Foundation Flanders (FWO), Brussels, Belgium. FAU - Cardon, Greet AU - Cardon G AD - Department of Movement and Sports Sciences, Ghent University, Belgium. FAU - De Paepe, Annick AU - De Paepe A AD - Department of Experimental-Clinical and Health Psychology, Ghent University, Belgium. FAU - Van Hove, Geert AU - Van Hove G AD - Department of Special Needs Education, Ghent University, Belgium. FAU - Crombez, Geert AU - Crombez G AD - Department of Experimental-Clinical and Health Psychology, Ghent University, Belgium. LA - eng PT - Journal Article DEP - 20260418 PL - England TA - Soc Sci Med JT - Social science & medicine (1982) JID - 8303205 SB - IM MH - Humans MH - Female MH - Adolescent MH - *Intellectual Disability/psychology/therapy MH - *Health Promotion/methods/standards MH - *Exercise/psychology MH - Male MH - Young Adult MH - Program Evaluation/methods MH - Accelerometry/methods OTO - NOTNLM OT - Dyadic intervention OT - Evaluation OT - Intellectual disabilities OT - Physical activity OT - Program theory OT - Theory-based OT - Youth COIS- Declaration of competing interest The authors declare that they have no competing interests. EDAT- 2026/04/27 00:30 MHDA- 2026/05/07 00:32 CRDT- 2026/04/26 18:09 PHST- 2025/10/31 00:00 [received] PHST- 2026/04/06 00:00 [revised] PHST- 2026/04/13 00:00 [accepted] PHST- 2026/05/07 00:32 [medline] PHST- 2026/04/27 00:30 [pubmed] PHST- 2026/04/26 18:09 [entrez] AID - S0277-9536(26)00379-5 [pii] AID - 10.1016/j.socscimed.2026.119303 [doi] PST - ppublish SO - Soc Sci Med. 2026 Jul;400:119303. doi: 10.1016/j.socscimed.2026.119303. Epub 2026 Apr 18. PMID- 42035008 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 1471-2369 (Electronic) IS - 1471-2369 (Linking) VI - 27 IP - 1 DP - 2026 Apr 25 TI - Kidney function among adult sickle cell disease patients at Ahmadu Bello University Teaching Hospital, Zaria, Nigeria. LID - 10.1186/s12882-026-04999-7 [doi] LID - 361 AB - BACKGROUND: Sickle cell disease (SCD) patients are certainly experiencing improved longevity with improved care and it is not unexpected that long-term complications including kidney diseases are being seen more often than before. Unfortunately, late diagnosis is not unusual. This can in part be explained by some aspects of pathogenesis of kidney disease in SCD including body compensatory mechanisms such as hyperfiltration with its associated lower creatinine levels and exaggerated estimated glomerular filtration rate (eGFR). Worse still, no single eGFR formula has been validated across board in this patient population. Based on the forgoing, it is not surprising that there is paucity of data regarding kidney disease among SCD patients even in Nigeria with 2-3% of her population affected, with about 150,000 new-borns affected yearly and 50 million people carrying the sickle cell trait representing the highest burden of SCD globally. Hence, this study is relevant to the field of nephrology as it is expected to draw attention to this emerging cause of kidney disease as it were and also serve as a reminder to non-nephrologists to look beyond serum creatinine levels and eGFR to assess urine of SCD patients for early evidence of kidney disease including loss of urine concentration and pH regulation ability as well as microalbuminuria. AIMS: (1) This study was conducted to evaluate kidney function among patients with SCD in ABUTH, Zaria. (2) To assess the relationship of BMI, sex, age, Blood pressure, and disease duration, on kidney dysfunction among patients with SCD in ABUTH, Zaria. METHOD: This was cross sectional descriptive study involving 210 SCD patients (188 HbSS and 22 HbSC) attending Haematology Clinic in ABUTH Zaria and 210 apparently healthy controls. The subject and control groups were selected using convenience sampling technique. Clinical examinations such as body mass index, blood pressure, were done for both patients and controls. Glomerular Filtration Rates were estimated using (CKD-EPI equation). Albuminuria was quantified using albumin creatinine ratio. Tubular function was assessed for pH and specific gravity (SG) using dip sticks and hygrometer respectively. All data were checked for errors before entering into computer programme version 17.0 SPSS for windows. Categorical data were represented as diagram (charts and tables) while continuous variable data were represented as mean and standard deviation. Student t- test and Pearson's Chi square were used to test for relationship. RESULTS: The study found the prevalence of albuminuria to be 47.2% among patients with SCD in ABUTH Zaria. The prevalence of CKD from stages 3-5 using eGFR was found to be 8.6%. It was observed that 35.2% of the patients with SCD in this study were unable to acidify their urine and 33.3% of them have impaired ability to concentrate their urine. A significant relationship was observed between blood pressure, and ACR with p < 0.001. An inverse relationship between blood pressure and eGFR was observed with p < 0.001. The study shows a significant inverse relationship between age and eGFR with p < 0.001. A positive significant relationship was observed between age and ACR p < 0.001. No significant relationship was observed between BMI and kidney function. Limitations of this study: (1) Lack of determination of HbF to determine its impacts on kidney function. (2) History of use of Hydroxyurea and its impacts on kidney function couldn't be obtained. CONCLUSION: This study has shown high prevalence of albuminuria, impaired urine acidification and urine concentrating ability among patients with SCD. A significant relationship was observed between increasing age, BP and kidney dysfunction (albuminuria, eGFR,) among patients with SCD in ABUTH Zaria. This study therefore, highlights the importance of early screening and detection of markers of chronic kidney among patients with SCD, so that early intervention can be deployed to retard its progression. FAU - Musa, Oguche Sunday AU - Musa OS AD - Renal Unit, Department of Medicine, ABUTH- Zaria, Shika, Zaria, Nigeria. FAU - Ibrahim, Kwaifa Salihu AU - Ibrahim KS AD - Renal Unit, Department of Medicine, ABUTH- Zaria, Shika, Zaria, Nigeria. kwaifasalihu@gmail.com. AD - Depart of Internal Medicine Wuse District Hospital, Abuja, Nigeria. kwaifasalihu@gmail.com. AD - Department of Medicine, Nile University, Abuja, Nigeria. kwaifasalihu@gmail.com. FAU - Bosan, Istifanus Bala AU - Bosan IB AD - Renal Unit, Department of Medicine, ABUTH- Zaria, Shika, Zaria, Nigeria. FAU - Ibrahim, Abubakar AU - Ibrahim A AD - Renal Unit, Department of Medicine, ABUTH- Zaria, Shika, Zaria, Nigeria. FAU - Abdul-Aziz, Hassan AU - Abdul-Aziz H AD - Department of Haematology, ABUTH Zaria, Shika, Zaria, Nigeria. FAU - Moses, Tuko Tari AU - Moses TT AD - Renal Unit, Department of Medicine, ABUTH- Zaria, Shika, Zaria, Nigeria. LA - eng PT - Journal Article DEP - 20260425 PL - England TA - BMC Nephrol JT - BMC nephrology JID - 100967793 RN - AYI8EX34EU (Creatinine) SB - IM MH - Humans MH - Female MH - *Anemia, Sickle Cell/physiopathology/epidemiology/diagnosis MH - Nigeria/epidemiology MH - Male MH - Adult MH - *Glomerular Filtration Rate/physiology MH - Young Adult MH - *Hospitals, Teaching/trends MH - Cross-Sectional Studies MH - Middle Aged MH - Creatinine/blood MH - Albuminuria/epidemiology MH - *Kidney/physiopathology MH - *Kidney Diseases/epidemiology/physiopathology/diagnosis MH - Kidney Function Tests MH - Adolescent PMC - PMC13270705 OTO - NOTNLM OT - Albuminuria OT - Kidney functions OT - Sickle cell disease OT - Urinary Specific gravity COIS- Declarations. Ethical approval: Ethical approval for the study was sought and obtained from abuth health research ethics committee (HREC). according to helsinki abuth/hrec/cl/05. Consent for publication: All authors have read and approved the final version of this manuscript and consented to its submission to the BMC journal. The authors have confirmed that the work is original and has not been submitted for publication previously and is not under any consideration elsewhere. Competing interests: The authors declare no competing interests. EDAT- 2026/04/26 06:38 MHDA- 2026/06/28 06:36 PMCR- 2026/04/25 CRDT- 2026/04/26 00:08 PHST- 2025/06/17 00:00 [received] PHST- 2026/04/14 00:00 [accepted] PHST- 2026/06/28 06:36 [medline] PHST- 2026/04/26 06:38 [pubmed] PHST- 2026/04/26 00:08 [entrez] PHST- 2026/04/25 00:00 [pmc-release] AID - 10.1186/s12882-026-04999-7 [pii] AID - 4999 [pii] AID - 10.1186/s12882-026-04999-7 [doi] PST - epublish SO - BMC Nephrol. 2026 Apr 25;27(1):361. doi: 10.1186/s12882-026-04999-7. PMID- 42034922 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260805 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 89 DP - 2026 Jul-Aug TI - The role of wearable technologies in symptom management and psychosocial outcomes among pediatric oncology and hematology patients: A systematic review. PG - 153-161 LID - S0882-5963(26)00170-3 [pii] LID - 10.1016/j.pedn.2026.04.009 [doi] AB - BACKGROUND: Wearable technologies (WD), including biosensors, smartwatches, and activity trackers, are increasingly applied in pediatric healthcare as non-pharmacological and supportive tools for symptom monitoring and psychosocial well-being. Despite their growing use, no prior systematic review has synthesized evidence on their application in pediatric oncology and hematology populations. This review aimed to evaluate the effectiveness, feasibility, and acceptability of WD in improving symptom management and psychosocial outcomes among these patients. METHODS: A systematic search was conducted in PubMed, Cochrane Library, MEDLINE (OVID), Scopus, Web of Science, and CINAHL. Eligible studies were randomized controlled trials or quasi-experimental studies involving pediatric oncology or hematology patients using WD for symptom monitoring, physical activity tracking, or psychosocial support. The review followed PRISMA 2020 guidelines, and study quality was assessed using the Joanna Briggs Institute critical appraisal tools. RESULTS: Four studies with a total of 112 participants met inclusion criteria. Interventions employed devices such as Empatica E4, Everion(R), CORE(R), and Fitbit Flex. Wearables were generally feasible and acceptable, with adherence rates ranging from 58% to 95%. Reported benefits included alignment of WD-derived physiological data with clinical vital signs, identification of pain-related distress through biophysical markers, modest improvements in social functioning and motivation, and high parental and patient acceptance. Key limitations included small sample sizes, technical barriers, and inconsistent compliance. CONCLUSION: Wearable technologies show promise for supporting real-time symptom monitoring, pain management, and psychosocial well-being in pediatric oncology and hematology care. Larger, multicenter randomized controlled trials are needed to confirm effectiveness and guide clinical implementation. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Sahin Tokatlioglu, Tugba AU - Sahin Tokatlioglu T AD - Istanbul Aydin University, Faculty of Health Sciences, Department of Nursing, Istanbul, Turkiye. Electronic address: tsahintokatlioglu@aydin.edu.tr. FAU - Karadede, Huriye AU - Karadede H AD - Istanbul Aydin University, Faculty of Health Sciences, Department of Nursing, Istanbul, Turkiye. Electronic address: huriyekaradede@aydin.edu.tr. FAU - Oflaz, Fahriye AU - Oflaz F AD - Koc University, School of Nursing, Istanbul, Turkiye. Electronic address: foflaz@ku.edu.tr. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260424 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM MH - Humans MH - *Wearable Electronic Devices MH - Child MH - *Neoplasms/psychology/therapy MH - Digital Health MH - Female MH - Adolescent MH - Male OTO - NOTNLM OT - Nursing care OT - Pediatric oncology OT - Supportive care OT - Wearable technology COIS- Declaration of competing interest The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/04/26 06:38 MHDA- 2026/07/14 12:35 CRDT- 2026/04/26 00:06 PHST- 2025/09/03 00:00 [received] PHST- 2026/04/10 00:00 [revised] PHST- 2026/04/10 00:00 [accepted] PHST- 2026/07/14 12:35 [medline] PHST- 2026/04/26 06:38 [pubmed] PHST- 2026/04/26 00:06 [entrez] AID - S0882-5963(26)00170-3 [pii] AID - 10.1016/j.pedn.2026.04.009 [doi] PST - ppublish SO - J Pediatr Nurs. 2026 Jul-Aug;89:153-161. doi: 10.1016/j.pedn.2026.04.009. Epub 2026 Apr 24. PMID- 42034862 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20261010 IS - 1433-0350 (Electronic) IS - 0256-7040 (Linking) VI - 42 IP - 1 DP - 2026 Apr 25 TI - Ultrasonographic assessment of subarachnoid space width in healthy infants aged 0-3 months: normative data and associations with anthropometric parameters. LID - 180 [pii] LID - 10.1007/s00381-026-07278-w [doi] AB - PURPOSE: The aim of this study was to establish ultrasonography-based reference values for subarachnoid space width and to examine associations between anthropometric Z-scores and these measurements in healthy infants aged 0-3 months. METHODS: This retrospective cross-sectional study included 125 healthy infants aged 0-3 months who underwent cranial ultrasound examinations. Subarachnoid space dimensions were measured bilaterally at the coronal level of the foramen of Monro, including craniocortical width (CCW), sinocortical width (SCW), and interhemispheric width (IHW). Age, body weight (BW), body height (BH), body mass index (BMI), body surface area (BSA), and head circumference (HC) Z-scores were analyzed for associations with subarachnoid space dimensions. Intraobserver reliability was evaluated using the intraclass correlation coefficient (ICC, two-way mixed-effects model). RESULTS: Mean values for CCW, SCW, and IHW increased progressively with age. Age was the only variable independently associated with CCW and SCW, while no significant anthropometric associations were found for IHW. Based on the 95th percentile, the proposed upper limits were 3.1 mm for CCW, 3.8 mm for SCW, and 4.2 mm for IHW. ICC values ranged from 0.93 to 0.95, indicating excellent intraobserver agreement. CONCLUSIONS: This study establishes ultrasonography-based normative data and describes growth-related associations for subarachnoid space width during the first 3 months of life. These findings provide a practical reference for interpreting subarachnoid space dimensions during early infancy. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Colak, Edis AU - Colak E AD - Department of Pediatric Radiology, Dr. Behcet Uz Children's Disease and Pediatric Surgery Training and Research Hospital, Izmir Faculty of Medicine, University of Health Sciences, Izmir, Turkey. drediscolak@gmail.com. AD - Department of Biophysics, Faculty of Medicine, Ege University, Izmir, Turkey. drediscolak@gmail.com. FAU - Karaoglu, Pakize AU - Karaoglu P AD - Department of Pediatric Neurology, Dr. Behcet Uz Children's Disease and Pediatric Surgery Training and Research Hospital, Izmir Faculty of Medicine, University of Health Sciences, Izmir, Turkey. FAU - Karaman, Huseyin Husnu AU - Karaman HH AD - Department of Pediatric Radiology, Dr. Behcet Uz Children's Disease and Pediatric Surgery Training and Research Hospital, Izmir Faculty of Medicine, University of Health Sciences, Izmir, Turkey. FAU - Unalp, Aycan AU - Unalp A AD - Department of Pediatric Neurology, Dr. Behcet Uz Children's Disease and Pediatric Surgery Training and Research Hospital, Izmir Faculty of Medicine, University of Health Sciences, Izmir, Turkey. FAU - Orbatu, Dilek AU - Orbatu D AD - Department of Neonatal Intensive Care, Dr. Behcet Uz Children's Disease and Pediatric Surgery Training and Research Hospital, Izmir Faculty of Medicine, University of Health Sciences, Izmir, Turkey. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260425 PL - Germany TA - Childs Nerv Syst JT - Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery JID - 8503227 SB - IM MH - Humans MH - *Subarachnoid Space/diagnostic imaging/anatomy & histology MH - Infant MH - Male MH - Female MH - Infant, Newborn MH - Cross-Sectional Studies MH - Reference Values MH - Retrospective Studies MH - *Anthropometry MH - Ultrasonography OTO - NOTNLM OT - Anthropometric associations OT - Cerebrospinal fluid OT - Cranial ultrasonography OT - Infants OT - Intraclass correlation coefficient OT - Normative data OT - Subarachnoid space COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Institutional Ethics Committee (Protocol No. GOA-217). Consent for publication: The authors affirm that human research participants provided informed consent for publication of the images in Figs. 1, 2, and 3. Conflict of interest: The authors declare no competing interests. EDAT- 2026/04/26 05:13 MHDA- 2026/04/26 06:38 CRDT- 2026/04/25 23:58 PHST- 2025/11/07 00:00 [received] PHST- 2026/04/14 00:00 [accepted] PHST- 2026/04/26 06:38 [medline] PHST- 2026/04/26 05:13 [pubmed] PHST- 2026/04/25 23:58 [entrez] AID - 10.1007/s00381-026-07278-w [pii] AID - 10.1007/s00381-026-07278-w [doi] PST - epublish SO - Childs Nerv Syst. 2026 Apr 25;42(1):180. doi: 10.1007/s00381-026-07278-w. PMID- 42034124 OWN - NLM STAT- MEDLINE DCOM- 20260811 LR - 20260811 IS - 1878-1632 (Electronic) IS - 1529-9430 (Linking) VI - 26 IP - 9 DP - 2026 Sep TI - Environmental factors rather than genetics likely drive vitamin D deficiency in idiopathic scoliosis. PG - 1843-1851 LID - S1529-9430(26)00132-4 [pii] LID - 10.1016/j.spinee.2026.04.026 [doi] AB - BACKGROUND CONTEXT: Low vitamin D levels in individuals with idiopathic scoliosis (IS) have been reported and suggested as a potential contributor to IS. Bone density has also been shown to be lower in individuals with IS. PURPOSE: To investigate serum levels of vitamin D, parathyroid hormone (PTH), markers of bone metabolism, and the genetic variation associated with vitamin D levels and bone density in individuals with IS and healthy controls. STUDY DESIGN/SETTING: Case-control study combining Scandinavian serum cohorts and genetic cohorts. PATIENT SAMPLE: Serum analyses: 174 individuals with IS and 153 nonscoliotic controls. GENETIC ANALYSES: A total of 1,394 individuals with IS and 11,108 controls. OUTCOME MEASURES: Serum 25-hydroxyvitamin D (25OHD), PTH, C-terminal telopeptide (CTX), osteocalcin, calcium, phosphate, creatinine, albumin, alkaline phosphatase, and leptin. Polygenic risk scores (PRS) for 25OHD and bone mineral density (BMD). METHODS: Serum samples were analyzed using validated clinical laboratory methods. PRS for 25OHD and BMD were calculated based on previous literature. Statistical analyses were performed using Mann-Whitney U tests, logistic, and linear regression. Mendelian randomization was analyzed using logistic regression and the inverse-variance weighted method. RESULTS: In the serum cohort, median 25OHD levels were 54.4 nmol/L in individuals with IS and 67.0 nmol/L in controls. Corresponding PTH levels were 4.0 and 3.2 pmol/L. No statistically significant differences were found in CTX, osteocalcin, alkaline phosphatase, or leptin. PRS for 25OHD was associated with serum 25OHD levels. PRS in individuals with IS and controls were nonsignificant for 25OHD, BMD femoral neck, and BMD lumbar spine. A tendency for lower values for estimated BMD heel was seen in individuals with scoliosis compared to controls. CONCLUSIONS: Our findings indicate altered regulation of the vitamin D-PTH axis in IS, likely driven by environmental rather than genetic factors. Bone turnover markers were comparable between groups; no clear genetically mediated BMD differences could be observed. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Georgopoulos, Ioannis AU - Georgopoulos I AD - Department of Surgical Sciences, Orthopaedics and Hand Surgery, Uppsala University, Uppsala, Sweden; Department of Orthopaedics and Hand Surgery, Uppsala University Hospital, SE-751 85 Uppsala, Sweden. Electronic address: ioannis.georgopoulos@uu.se. FAU - Cheng, Tian AU - Cheng T AD - Department of Surgical Sciences, Orthopaedics and Hand Surgery, Uppsala University, Uppsala, Sweden; Department of Orthopaedics and Hand Surgery, Uppsala University Hospital, SE-751 85 Uppsala, Sweden. FAU - Fell, Daniel AU - Fell D AD - Department of Spinal Surgery, Nacka Hospital, Stockholm, Sweden. FAU - Simony, Ane AU - Simony A AD - Department of Regional Health Research, University of Southern Denmark, Odense, Denmark; Department of Orthopaedic Surgery, Lillebaelt Hospital, Kolding, Denmark. FAU - Andersen, Mikkel O AU - Andersen MO AD - Department of Spine Surgery and Research, Lillebaelt Hospital, Kolding, Denmark. FAU - Einarsdottir, Elisabet AU - Einarsdottir E AD - Science for Life Laboratory, Department of Gene Technology, KTH Royal Institute of Technology, Solna, Sweden. FAU - Karlsson, Magnus K AU - Karlsson MK AD - Department of Clinical Sciences, Lund University, Malmo, Sweden; Department of Orthopaedics, Skane University Hospital, Malmo, Sweden. FAU - Bergstrom, Ingrid AU - Bergstrom I AD - Department of Clinical Sciences and Education, Sodersjukhuset, Karolinska Institutet, Stockholm, Sweden. FAU - Diarbakerli, Elias AU - Diarbakerli E AD - Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden; Department of Reconstructive Orthopaedics, Karolinska University Hospital, Stockholm, Sweden. FAU - Schizas, Nikos AU - Schizas N AD - Department of Surgical Sciences, Orthopaedics and Hand Surgery, Uppsala University, Uppsala, Sweden; Department of Orthopaedics and Hand Surgery, Uppsala University Hospital, SE-751 85 Uppsala, Sweden. FAU - Gerdhem, Paul AU - Gerdhem P AD - Department of Surgical Sciences, Orthopaedics and Hand Surgery, Uppsala University, Uppsala, Sweden; Department of Orthopaedics and Hand Surgery, Uppsala University Hospital, SE-751 85 Uppsala, Sweden; Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden. LA - eng PT - Journal Article DEP - 20260423 PL - United States TA - Spine J JT - The spine journal : official journal of the North American Spine Society JID - 101130732 RN - 1406-16-2 (Vitamin D) RN - 0 (Parathyroid Hormone) RN - A288AR3C9H (25-hydroxyvitamin D) RN - 104982-03-8 (Osteocalcin) SB - IM MH - Humans MH - *Scoliosis/blood/genetics/complications MH - Female MH - *Vitamin D Deficiency/blood/genetics/complications MH - Bone Density MH - Vitamin D/blood/analogs & derivatives MH - Male MH - Parathyroid Hormone/blood MH - Case-Control Studies MH - Adolescent MH - Child MH - Osteocalcin/blood OTO - NOTNLM OT - Bone metabolism OT - Bone mineral density OT - Idiopathic scoliosis OT - Polygenic risk score OT - Serum level of 25OHD OT - Vitamin D COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/26 05:13 MHDA- 2026/08/11 23:35 CRDT- 2026/04/25 19:19 PHST- 2026/01/25 00:00 [received] PHST- 2026/04/06 00:00 [revised] PHST- 2026/04/20 00:00 [accepted] PHST- 2026/08/11 23:35 [medline] PHST- 2026/04/26 05:13 [pubmed] PHST- 2026/04/25 19:19 [entrez] AID - S1529-9430(26)00132-4 [pii] AID - 10.1016/j.spinee.2026.04.026 [doi] PST - ppublish SO - Spine J. 2026 Sep;26(9):1843-1851. doi: 10.1016/j.spinee.2026.04.026. Epub 2026 Apr 23. PMID- 42034097 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260612 IS - 1878-1799 (Electronic) IS - 1871-5192 (Linking) VI - 39 IP - 3 DP - 2026 Jun TI - Implementation of early postnatal discharge within 24 h in France: Safety, satisfaction, and feasibility trial supported by a connected home monitoring application (NICE-BIRTH study). PG - 102205 LID - S1871-5192(26)00046-6 [pii] LID - 10.1016/j.wombi.2026.102205 [doi] AB - PROBLEM: France maintains one of the longest mean postpartum lengths of stay in Europe. BACKGROUND: Shortening hospitalization requires ensuring safety and continuity of care in a healthcare system traditionally unaccustomed to ambulatory postpartum management. AIM: To evaluate the safety and feasibility of an early postnatal discharge within 24 h (EPD) protocol supported by a digital platform and community-based midwifery. METHODS: A prospective cohort study was conducted on 100 low-risk mother-infant dyads. The protocol involved strict inclusion criteria, antenatal preparation, discharge within 24 h, and daily home monitoring by community-based midwives coordinated via the "Link4Life" mobile application. Primary outcomes included maternal and neonatal readmissions, breastfeeding rates, and satisfaction. FINDINGS: Full compliance with national recommendations was achieved. No maternal readmissions occurred within the first month. Four neonates (4%) were readmitted for late-onset infections unrelated to early discharge. Pain was effectively managed with Level 1 analgesics. At one month, 98.6% of initiating mothers were still breastfeeding. Satisfaction scores reached 9.7/10 for both mothers and midwives. DISCUSSION: Our findings indicate a favorable preliminary safety profile and very high breastfeeding maintenance when the hospital-community transition is secured via digital innovation and dedicated professional support. CONCLUSION: EPD is a feasible and highly satisfactory alternative to standard care in settings where such practices are currently non-standard. This illustrates how digital health can facilitate a strategic reallocation of hospital resources toward high-value, personalized community-based support. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Gauci, Pierre-Alexis AU - Gauci PA AD - Department of Obstetrics and Gynecology, Reproduction and Fetal Medicine, Universite Cote d'Azur - Centre Hospitalier Universitaire de Nice, France. Electronic address: pierre-alexis.gauci@univ-cotedazur.fr. FAU - Adrados, Caroline AU - Adrados C AD - Department of Obstetrics and Gynecology, Reproduction and Fetal Medicine, Universite Cote d'Azur - Centre Hospitalier Universitaire de Nice, France. FAU - Albouy, Cecile AU - Albouy C AD - Department of Obstetrics and Gynecology, Reproduction and Fetal Medicine, Universite Cote d'Azur - Centre Hospitalier Universitaire de Nice, France. FAU - Roy, Marianne AU - Roy M AD - Department of Obstetrics and Gynecology, Reproduction and Fetal Medicine, Universite Cote d'Azur - Centre Hospitalier Universitaire de Nice, France. FAU - Walrave, Yannick AU - Walrave Y AD - Department of Pediatric Anaesthesia and Intensive Care, Clinique Saint George, Nice, France; Link4Life, Nice, France. FAU - Marioli, Sandrine AU - Marioli S AD - Department of Obstetrics and Gynecology, Reproduction and Fetal Medicine, Universite Cote d'Azur - Centre Hospitalier Universitaire de Nice, France. FAU - Benamer, Latifa AU - Benamer L AD - Department of Obstetrics and Gynecology, Reproduction and Fetal Medicine, Universite Cote d'Azur - Centre Hospitalier Universitaire de Nice, France. FAU - Delotte, Jerome AU - Delotte J AD - Department of Obstetrics and Gynecology, Reproduction and Fetal Medicine, Universite Cote d'Azur - Centre Hospitalier Universitaire de Nice, France. LA - eng PT - Journal Article DEP - 20260424 PL - Netherlands TA - Women Birth JT - Women and birth : journal of the Australian College of Midwives JID - 101266131 SB - IM MH - Humans MH - Female MH - France MH - *Patient Discharge MH - Prospective Studies MH - *Patient Satisfaction MH - *Postnatal Care/methods MH - Adult MH - Feasibility Studies MH - Breast Feeding/statistics & numerical data MH - Pregnancy MH - Infant, Newborn MH - Midwifery MH - Postpartum Period MH - *Mobile Applications MH - Patient Readmission/statistics & numerical data MH - Length of Stay MH - Mothers OTO - NOTNLM OT - Ambulatory care OT - Birth OT - Home monitoring OT - Satisfaction COIS- Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Yannick WALRAVE reports a relationship with Link4Life that includes: board membership. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/26 05:13 MHDA- 2026/06/12 13:04 CRDT- 2026/04/25 18:49 PHST- 2026/01/25 00:00 [received] PHST- 2026/03/30 00:00 [revised] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/06/12 13:04 [medline] PHST- 2026/04/26 05:13 [pubmed] PHST- 2026/04/25 18:49 [entrez] AID - S1871-5192(26)00046-6 [pii] AID - 10.1016/j.wombi.2026.102205 [doi] PST - ppublish SO - Women Birth. 2026 Jun;39(3):102205. doi: 10.1016/j.wombi.2026.102205. Epub 2026 Apr 24. PMID- 42034078 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 1525-5069 (Electronic) IS - 1525-5050 (Linking) VI - 181 DP - 2026 Aug TI - Caregiver perspectives on disease burden and treatment priorities in KCNT1-related disorders. PG - 111053 LID - S1525-5050(26)00174-5 [pii] LID - 10.1016/j.yebeh.2026.111053 [doi] AB - BACKGROUND: Pathogenic variants in KCNT1, encoding the sodium-activated potassium channel K(Na)1.1 (Slack), cause severe developmental and epileptic encephalopathies marked by early-onset, treatment-resistant seizures and profound neurodevelopmental impairment. While clinical and electrophysiological features are well described, systematic caregiver-reported data on treatment effectiveness and family impact are limited. METHODS: The KCNT1 Epilepsy Foundation established an international online caregiver-reported registry. Caregivers of individuals with a clinical and/or genetic diagnosis of a KCNT1-related disorder completed structured surveys between April 2023 and January 2024. Data included demographics, genetic variants, seizure characteristics, treatment history, sleep behaviors, quality of life, and family impact using validated and custom instruments. RESULTS: Data from 62 individuals across 13 countries were analyzed. Seizure onset was early (median: 1 month), with diagnosis occurring shortly thereafter (median: 4 months). Sixteen distinct KCNT1 missense variants were reported across the cohort. Caregivers reported a high treatment burden, with a median of 2.5 concurrent antiseizure therapies. The ketogenic diet, clobazam, phenobarbital, and levetiracetam, and vagus nerve stimulation were perceived as highly beneficial, while many conventional antiseizure medications showed limited benefit or worsening. Profound challenges were reported, particularly in cognitive and physical functioning, along with substantial emotional and practical family burden. Treatment priorities extended beyond seizure control to include communication, overall health, and quality of life, with notable gaps between priorities and perceived effectiveness. CONCLUSIONS: Caregiver-reported data demonstrate severe burden and substantial unmet needs in KCNT1-related disorders, highlighting the importance of patient- and family-centered outcome measures in care and therapeutic development. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Bryan, Brad A AU - Bryan BA AD - KCNT1 Epilepsy Foundation, 32531 N Scottsdale Rd, Ste 105-530, Scottsdale, AZ, USA. Electronic address: brad.bryan@kcnt1epilepsy.org. FAU - Faria, Victor AU - Faria V AD - KCNT1 Epilepsy Foundation, 32531 N Scottsdale Rd, Ste 105-530, Scottsdale, AZ, USA. FAU - Esposito, Kaitlyn AU - Esposito K AD - KCNT1 Epilepsy Foundation, 32531 N Scottsdale Rd, Ste 105-530, Scottsdale, AZ, USA. FAU - Boyce, Danielle AU - Boyce D AD - Tufts Clinical and Translational Science Institute, 35 Kneeland St, Boston, MA, USA. FAU - Poliquin, Sarah AU - Poliquin S AD - COMBINEDBrain, 1510 Old Hickory Blvd, Brentwood, TN, USA. FAU - Terry, Ian AU - Terry I AD - Formerly at LunaDNA, 10070 Mesa Rim Road, San Diego, CA, USA; Aretetic Solutions, 2108 N Street #12398, Sacramento, CA, USA. FAU - Wright, Megan AU - Wright M AD - KCNT1 Epilepsy Foundation, 32531 N Scottsdale Rd, Ste 105-530, Scottsdale, AZ, USA. FAU - Abuhl, Amanda AU - Abuhl A AD - KCNT1 Epilepsy Foundation, 32531 N Scottsdale Rd, Ste 105-530, Scottsdale, AZ, USA. FAU - Rosenberg, Allison AU - Rosenberg A AD - KCNT1 Epilepsy Foundation, 32531 N Scottsdale Rd, Ste 105-530, Scottsdale, AZ, USA. FAU - Bearden, David AU - Bearden D AD - University of Rochester Medical Center, Department of Neurology, 601 Elmwood Ave, Rochester, NY, USA. FAU - West, Justin AU - West J AD - KCNT1 Epilepsy Foundation, 32531 N Scottsdale Rd, Ste 105-530, Scottsdale, AZ, USA. FAU - Drislane, Sarah AU - Drislane S AD - KCNT1 Epilepsy Foundation, 32531 N Scottsdale Rd, Ste 105-530, Scottsdale, AZ, USA. LA - eng PT - Journal Article DEP - 20260424 PL - United States TA - Epilepsy Behav JT - Epilepsy & behavior : E&B JID - 100892858 RN - 0 (KCNT1 protein, human) RN - 0 (Potassium Channels, Sodium-Activated) RN - 0 (Nerve Tissue Proteins) RN - 0 (Anticonvulsants) SB - IM MH - Humans MH - Female MH - *Caregivers/psychology MH - Male MH - *Cost of Illness MH - Child MH - Adult MH - *Epilepsy/genetics/therapy MH - *Potassium Channels, Sodium-Activated/genetics MH - Quality of Life MH - *Nerve Tissue Proteins/genetics MH - Child, Preschool MH - Adolescent MH - Infant MH - Young Adult MH - Middle Aged MH - Anticonvulsants/therapeutic use OTO - NOTNLM OT - Caregiver reported outcomes OT - Developmental and epileptic encephalopathy OT - Epilepsy OT - Family impact OT - KCNT1 OT - Quality of life COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/26 05:13 MHDA- 2026/05/23 05:39 CRDT- 2026/04/25 18:49 PHST- 2026/02/03 00:00 [received] PHST- 2026/04/08 00:00 [revised] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/05/23 05:39 [medline] PHST- 2026/04/26 05:13 [pubmed] PHST- 2026/04/25 18:49 [entrez] AID - S1525-5050(26)00174-5 [pii] AID - 10.1016/j.yebeh.2026.111053 [doi] PST - ppublish SO - Epilepsy Behav. 2026 Aug;181:111053. doi: 10.1016/j.yebeh.2026.111053. Epub 2026 Apr 24. PMID- 42033951 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 1878-7487 (Electronic) IS - 1752-928X (Linking) VI - 120 DP - 2026 May TI - Automated dental age estimation model for panoramic radiographs. PG - 103148 LID - S1752-928X(26)00080-6 [pii] LID - 10.1016/j.jflm.2026.103148 [doi] AB - BACKGROUND & OBJECTIVES: Developmental stages of the dentition and age-group classification are crucial in forensic odontology, oral radiology, pediatric dentistry, and orthodontic dentistry. However, the manual interpretation of dental panoramic (OPG) radiographs for assessing the developmental stages and further age-group classification is time-consuming and prone to variability. This current model aims to evaluate the performance of a computational neural network (CNN) based model for automated detection of Nolla's developmental stages of permanent teeth and subsequent dental age group classification using digital OPGs from individuals aged 3 - 30 years. MATERIALS AND METHODS: Nolla's method was selected for its broad applicability to all the permanent teeth, including the developing third molar, and its comprehensive staging system. A total of 4073 radiographic images for Nolla's developmental stages (0 to 10) and age-group classification were utilized for training and validation of an annotated dataset, with an independent dataset of 1450 anonymized radiographs with varying quality and 644 repository images for testing of the YOLOv8-based models. RESULTS: For the developmental stage classification, the model achieved a precision of 0.912, recall rate of 0.927, F1 score of 0.919, and a mean average precision (mAP) of 0.963. For age-group classification, the model demonstrated a precision of 0.83, recall of 0.79, F1 score of 0.81, and mAP of 0.88. The overall performance was highest in the mid-age range, and the lower metrics were observed in younger age groups less than 6 years of age. CONCLUSION & SIGNIFICANCE: The current model effectively identifies and classifies the developmental stages of permanent teeth and estimates age from panoramic radiographs with high accuracy, especially in well-represented age groups. It emphasizes the feasibility of applying real-time object detection frameworks for age assessment. While not intended as a validated forensic age-group classification tool, the model provides a proof-of-concept for integrating real-time object detection approaches into dental developmental assessment workflows and establishes a foundation for future population-specific, sex stratified, and forensically validated models. CI - Copyright (c) 2026 Elsevier Ltd and Faculty of Forensic and Legal Medicine. All rights reserved. FAU - Akshaya, M AU - Akshaya M AD - Department of Oral Medicine & Radiology, Government Dental College & Research Institute, Bangalore, Karnataka, 560002, India. Electronic address: drakshayamurugan97@gmail.com. FAU - Vijayalakshmi, K R AU - Vijayalakshmi KR AD - Department of Oral Medicine & Radiology, Government Dental College & Research Institute, Bangalore, Karnataka, 560002, India. FAU - Kumar, T N R AU - Kumar TNR AD - Department of Computer Science, MS Ramaiah Institute of Technology, Bangalore, Karnataka, 560054, India. FAU - Rakshana, M AU - Rakshana M AD - Biomedical Engineering, Universitat Heidelberg, Heidelberg, Germany, 69117. LA - eng PT - Journal Article DEP - 20260420 PL - England TA - J Forensic Leg Med JT - Journal of forensic and legal medicine JID - 101300022 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - *Radiography, Panoramic MH - Child MH - Child, Preschool MH - Adolescent MH - Adult MH - Young Adult MH - Forensic Dentistry MH - Convolutional Neural Networks MH - Dentition, Permanent MH - Radiography, Dental, Digital MH - *Neural Networks, Computer OTO - NOTNLM OT - Age-group classification OT - Artificial intelligence OT - Forensic OT - Panoramic radiography COIS- Conflict of interest The authors declare that they have no known conflict of interest. EDAT- 2026/04/26 05:13 MHDA- 2026/05/31 05:33 CRDT- 2026/04/25 18:11 PHST- 2025/08/31 00:00 [received] PHST- 2026/01/06 00:00 [revised] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/05/31 05:33 [medline] PHST- 2026/04/26 05:13 [pubmed] PHST- 2026/04/25 18:11 [entrez] AID - S1752-928X(26)00080-6 [pii] AID - 10.1016/j.jflm.2026.103148 [doi] PST - ppublish SO - J Forensic Leg Med. 2026 May;120:103148. doi: 10.1016/j.jflm.2026.103148. Epub 2026 Apr 20. PMID- 42033785 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20261005 IS - 1462-0332 (Electronic) IS - 1462-0324 (Linking) VI - 65 IP - 5 DP - 2026 May 5 TI - Beyond muscle strength: functional performance measures enhance assessment of disease activity in juvenile dermatomyositis. LID - keag232 [pii] LID - 10.1093/rheumatology/keag232 [doi] AB - OBJECTIVES: To evaluate the measurement properties of functional performance measures (FPMs), broad jump (BJ) and 10-m run (10MR) in JDM, and to assess their added value alongside conventional clinical tools. METHODS: This longitudinal cohort study included 39 children with JDM. BJ and 10MR were assessed with Physician Global Assessment of Disease Activity (PGA), Cutaneous Dermatomyositis Disease Area and Severity Index (CDASI), Manual Muscle Testing in 8 muscles (MMT8) and the Childhood Myositis Assessment Scale (CMAS) at baseline and follow-up visits (every 3-6 months). Construct validity and responsiveness were assessed through cross-sectional and longitudinal analyses. RESULTS: FPMs correlated significantly with disease activity and muscle function, with faster 10MR and longer BJ performance associated with lower PGA and higher CMAS/MMT8. 10MR and BJ demonstrated moderate responsiveness (standardized response mean = -0.56 and 0.31, respectively), and longitudinal analyses confirmed that FPM changes paralleled improvements in CMAS and MMT8 over time. Within the clinically inactive disease (CID) group, functional heterogeneity was evident. Cluster analysis based on CMAS and MMT8 identified a subgroup with relatively low strength scores and poor FPM performance, while a more comprehensive four-variable clustering using BJ, 10MR, CMAS and MMT8 further stratified CID patients into three distinct phenotypes. Notably, one subgroup exhibited high CMAS/MMT8 scores but reduced FPMs, indicating residual functional impairment not captured by traditional assessments. Low internal consistency (Cronbach's alpha = 0.44) further suggested that FPMs capture dimensions distinct from CMAS/MMT8. CONCLUSION: FPMs are quick, feasible tools that may provide complementary information on dynamic muscle performance not fully captured by CMAS or MMT8. Their ability to identify functional variability within CID patients supports their potential utility in monitoring functional recovery in JDM. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Shi, Jia AU - Shi J AUID- ORCID: 0009-0001-3995-6697 AD - Division of Rheumatology, University of Washington, Seattle, WA, USA. AD - Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Common Mechanism Research for Major Diseases, Beijing, China. FAU - Carpenter, Alexander AU - Carpenter A AD - Division of Rheumatology, Seattle Children's Hospital and Research Center, University of WA, Seattle, WA, USA. FAU - Wong, Christopher AU - Wong C AD - Division of Rheumatology, Seattle Children's Hospital and Research Center, University of WA, Seattle, WA, USA. FAU - Wang, Qian AU - Wang Q AUID- ORCID: 0000-0002-4541-9898 AD - Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College; National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC-DID), Ministry of Science & Technology, State Key Laboratory of Common Mechanism Research for Major Diseases, Beijing, China. FAU - Lood, Christian AU - Lood C AD - Division of Rheumatology, University of Washington, Seattle, WA, USA. FAU - Shenoi, Susan AU - Shenoi S AD - Division of Rheumatology, Seattle Children's Hospital and Research Center, University of WA, Seattle, WA, USA. LA - eng GR - Cure JM Foundation/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Rheumatology (Oxford) JT - Rheumatology (Oxford, England) JID - 100883501 SB - IM MH - Humans MH - *Dermatomyositis/physiopathology/diagnosis MH - Female MH - Male MH - Child MH - Longitudinal Studies MH - Severity of Illness Index MH - *Muscle Strength/physiology MH - Cross-Sectional Studies MH - *Physical Functional Performance MH - Adolescent MH - Reproducibility of Results MH - Exercise Test/methods MH - Muscle, Skeletal/physiopathology OTO - NOTNLM OT - 10-m run OT - broad jump OT - functional performance measures OT - juvenile dermatomyositis OT - muscle function EDAT- 2026/04/26 05:13 MHDA- 2026/05/21 06:32 CRDT- 2026/04/25 14:53 PHST- 2025/07/09 00:00 [received] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/05/21 06:32 [medline] PHST- 2026/04/26 05:13 [pubmed] PHST- 2026/04/25 14:53 [entrez] AID - 8662569 [pii] AID - 10.1093/rheumatology/keag232 [doi] PST - ppublish SO - Rheumatology (Oxford). 2026 May 5;65(5):keag232. doi: 10.1093/rheumatology/keag232. PMID- 42033144 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261009 IS - 1537-6591 (Electronic) IS - 1058-4838 (Print) IS - 1058-4838 (Linking) VI - 83 IP - 3 DP - 2026 Oct 7 TI - Updated Hepatitis D Seroprevalence Among Hepatitis B Surface Antigen-Positive Persons Aged >/=6 Years in the United States, National Health and Nutrition Examination Survey, 2007‒2018. PG - e530-e532 LID - 10.1093/cid/ciag274 [doi] AB - To validate the accuracy of previously published US seroprevalence estimates for hepatitis D virus (HDV) antibody, we retested National Health and Nutrition Examination Survey samples from 2007 to 2018 using a different assay. We found the HDV seroprevalence among hepatitis B surface antigen-positive participants aged >/=6 years to be 1.26%. CI - Published by Oxford University Press on behalf of Infectious Diseases Society of America 2026. FAU - Casillas, Shannon M AU - Casillas SM AUID- ORCID: 0000-0001-7819-910X AD - Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. FAU - Chida, Asiya AU - Chida A AUID- ORCID: 0000-0002-5730-1934 AD - Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. FAU - Drobeniuc, Jan AU - Drobeniuc J AUID- ORCID: 0000-0002-0735-8115 AD - Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. FAU - Sandul, Amy L AU - Sandul AL AUID- ORCID: 0000-0002-7623-8408 AD - Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. FAU - Kamili, Saleem AU - Kamili S AD - Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. FAU - Jiles, Ruth B AU - Jiles RB AUID- ORCID: 0000-0002-7132-4008 AD - Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. FAU - Thomas, David L AU - Thomas DL AUID- ORCID: 0000-0002-0749-925X AD - Division of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. FAU - Tobian, Aaron A R AU - Tobian AAR AUID- ORCID: 0000-0002-0517-3766 AD - Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. FAU - Patel, Eshan U AU - Patel EU AUID- ORCID: 0000-0003-2174-5004 AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA. FAU - Teshale, Eyasu H AU - Teshale EH AUID- ORCID: 0000-0001-5244-8251 AD - Division of Viral Hepatitis, National Center for HIV, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, Georgia, USA. LA - eng GR - CC999999/ImCDC/Intramural CDC HHS/United States GR - US Centers for Disease Control and Prevention/ GR - HH/HHS/United States PT - Journal Article PL - United States TA - Clin Infect Dis JT - Clinical infectious diseases : an official publication of the Infectious Diseases Society of America JID - 9203213 RN - 0 (Hepatitis B Surface Antigens) RN - 0 (Hepatitis Antibodies) SB - IM MH - Humans MH - Seroepidemiologic Studies MH - *Hepatitis D/epidemiology/immunology MH - United States/epidemiology MH - Nutrition Surveys MH - *Hepatitis B Surface Antigens/blood/immunology MH - Female MH - Adolescent MH - Male MH - Child MH - Adult MH - Hepatitis Delta Virus/immunology MH - Middle Aged MH - *Hepatitis B/epidemiology/immunology MH - *Hepatitis Antibodies/blood MH - Young Adult MH - Aged PMC - PMC13572982 MID - NIHMS2208869 OTO - NOTNLM OT - hepatitis B OT - hepatitis D OT - seroprevalence COIS- Potential conflicts of interest. D. L. T. reports receipt of grants or contracts from the National Institutes of Health and Unitaid; consulting fees from Excision Bio; participation on a Data Safety Monitoring Board or Advisory Board for Merck and Rho; leadership role for the CROI Program Committee; and receipt of donated testing materials from Abbott Diagnostics. All other authors report no conflicts of interest. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed. EDAT- 2026/04/25 06:33 MHDA- 2026/10/07 17:33 PMCR- 2026/09/15 CRDT- 2026/04/25 04:13 PHST- 2026/02/04 00:00 [received] PHST- 2026/03/25 00:00 [accepted] PHST- 2026/10/07 17:33 [medline] PHST- 2026/04/25 06:33 [pubmed] PHST- 2026/04/25 04:13 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - 8662345 [pii] AID - 10.1093/cid/ciag274 [doi] PST - ppublish SO - Clin Infect Dis. 2026 Oct 7;83(3):e530-e532. doi: 10.1093/cid/ciag274. PMID- 42032814 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260726 IS - 1098-4275 (Electronic) IS - 0031-4005 (Linking) VI - 158 IP - 1 DP - 2026 Jul 1 TI - Predicting Mortality in Tanzanian Children With Sepsis Using Point-of-Care Biomarkers. LID - e2026076344 [pii] LID - 10.1542/peds.2026-076344 [doi] AB - BACKGROUND AND OBJECTIVES: Sepsis is a leading cause of child mortality worldwide, disproportionately affecting children in resource-limited settings (RLSs). Effective risk-stratification tools using readily available data are urgently needed for this population. Therefore, the study objective was to evaluate the performance of point-of-care (POC) biomarkers and clinical characteristics for predicting in-hospital mortality among Tanzanian children with sepsis. METHODS: We conducted a prospective observational cohort study of children (aged 28 days-14 years) with sepsis presenting to Muhimbili National Hospital in Dar es Salaam, Tanzania (July 2022-November 2024). POC biomarkers (procalcitonin [PCT], C-reactive protein, ferritin, and lactate) and clinical characteristics were evaluated for their association with mortality. We used the least absolute shrinkage and selection operator regression to construct predictive models of mortality. We evaluated model performance using the area under the receiver operating characteristic curve (AUC) and classification metrics, including sensitivity and specificity. RESULTS: Among the 755 enrolled participants, 19.6% (n = 148) died during hospitalization. PCT and tested clinical characteristics were significantly associated with mortality (all P < .001). A multivariable model incorporating PCT, malnutrition, breathing difficulty, and altered mental status demonstrated strong discrimination (AUC 0.87, 95% CI [0.84-0.90]), outperforming individual biomarkers and clinical characteristics alone. CONCLUSIONS: A combined POC biomarker and clinical characteristics model was highly predictive of mortality among children with sepsis in Tanzania. Integrating POC biomarkers with easy-to-measure clinical characteristics associated with severity may enable timely risk stratification and inform targeted interventions to improve pediatric sepsis outcomes in RLSs. FAU - Sorensen, Abigail M AU - Sorensen AM AD - University of California, San Francisco, San Francisco, California. FAU - Mussa, Raya Y AU - Mussa RY AD - Muhimbili National Hospital, Dar es Salaam, Tanzania. FAU - Oltman, Scott P AU - Oltman SP AD - University of California, San Francisco, San Francisco, California. AD - Department of Epidemiology & Biostatistics, University of California, San Francisco, San Francisco, California. AD - University of California San Francisco, Institute for Global Health Sciences, San Francisco, California. FAU - Sunzula, Erasto M AU - Sunzula EM AD - Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Mlele, Victoria M AU - Mlele VM AD - Muhimbili National Hospital, Dar es Salaam, Tanzania. FAU - Msemwa, Cecilia L AU - Msemwa CL AD - Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Mathias, Lushona K AU - Mathias LK AD - Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Sun, Kathleen S AU - Sun KS AD - University of California, San Francisco, San Francisco, California. FAU - Maidana, Jazmin M Baez AU - Maidana JMB AD - University of California, San Francisco, San Francisco, California. FAU - Mkopi, Namala P AU - Mkopi NP AD - Muhimbili National Hospital, Dar es Salaam, Tanzania. FAU - Hooft, Anneka M AU - Hooft AM AD - University of California, San Francisco, San Francisco, California. FAU - Mfinanga, Juma A AU - Mfinanga JA AD - Muhimbili National Hospital, Dar es Salaam, Tanzania. FAU - Manyahi, Joel P AU - Manyahi JP AD - Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Sawe, Hendry R AU - Sawe HR AD - Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Kortz, Teresa B AU - Kortz TB AD - University of California, San Francisco, San Francisco, California. AD - University of California San Francisco, Institute for Global Health Sciences, San Francisco, California. LA - eng GR - K23 AI144029/AI/NIAID NIH HHS/United States PT - Journal Article PT - Observational Study PL - United States TA - Pediatrics JT - Pediatrics JID - 0376422 RN - 0 (Biomarkers) RN - 9007-41-4 (C-Reactive Protein) RN - 0 (Procalcitonin) RN - 9007-73-2 (Ferritins) SB - IM MH - Humans MH - Tanzania/epidemiology MH - *Sepsis/mortality/blood/diagnosis MH - Biomarkers/blood MH - Child, Preschool MH - Female MH - Prospective Studies MH - Infant MH - Male MH - *Point-of-Care Systems MH - *Hospital Mortality MH - Child MH - Adolescent MH - Infant, Newborn MH - Predictive Value of Tests MH - C-Reactive Protein/analysis MH - Procalcitonin/blood MH - Cohort Studies MH - Resource-Limited Settings MH - Ferritins/blood EDAT- 2026/04/25 06:33 MHDA- 2026/07/01 12:48 CRDT- 2026/04/25 00:03 PHST- 2026/03/09 00:00 [received] PHST- 2026/04/03 00:00 [accepted] PHST- 2026/07/01 12:48 [medline] PHST- 2026/04/25 06:33 [pubmed] PHST- 2026/04/25 00:03 [entrez] AID - 207285 [pii] AID - 10.1542/peds.2026-076344 [doi] PST - ppublish SO - Pediatrics. 2026 Jul 1;158(1):e2026076344. doi: 10.1542/peds.2026-076344. PMID- 42032341 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260921 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 5 DP - 2026 Apr 24 TI - Evaluation of the quality, reliability, and readability of ChatGPT-4 responses related to the treatment and rehabilitation of children with cerebral palsy. LID - 10.1007/s00431-026-06979-3 [doi] LID - 297 AB - This study aims to evaluate the reliability, quality, and readability of ChatGPT-4's responses to questions about cerebral palsy (CP) and rehabilitation strategies. The 56 most frequently asked questions by families about CP, its treatment, and rehabilitation strategies were divided into five categories (A1-5) and asked in ChatGPT-4. The reliability, quality, and readability of the responses were assessed by two researchers, respectively, using the modified DISCERN (mDISCERN) tool, the Global Quality Scale (GQS), and the Flesch Reading Ease Scale (FRE). Median (IQR) values for mDISCERN ranged from 3 (3-3) in A5 to 4 (3-4) in A1, while GQS values ranged from 3 (3-3.5) in A2 to 3.5 (3-4) in A1. The mean readability values assessed with FRE ranged from 31.47 +/- 12.92 to 44.84 +/- 17.39. No statistically significant differences were observed between the categories. The ICC values suggested very good agreement for both scales, with 0.851 for the mDISCERN total score and 0.824 for the GQS total score. CONCLUSION: This study suggests that ChatGPT-4 provides moderate reliability and generally acceptable quality of responses regarding CP treatment and rehabilitation. FRE scores indicated that many responses were difficult for families to understand. While ChatGPT-4 may serve as a supportive source of general information, its outputs should be interpreted with caution, particularly in clinical contexts, and supervision and oversight by healthcare professionals remain essential for safe and effective use. WHAT'S KNOWN: * Children with cerebral palsy (CP) receive lifelong rehabilitation. Exercise plays a fundamental role in maintaining functional independence and quality of life, as well as physical development. The use of AI-based tools such as ChatGPT-4 for health information is increasingly widespread; however, uncertainties regarding the reliability, quality,and readability of these tools remain. WHAT IS NEW: * Our study shows that ChatGPT-4''s responses to questions about treatment and rehabilitation strategies for children with CP have moderate to good reliability and quality, but low readability. CI - (c) 2026. The Author(s). FAU - Zorlular, Rabia AU - Zorlular R AUID- ORCID: 0000-0001-9007-553X AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Nigde Omer Halisdemir University, Nigde, Turkey. rabiaeraslan@ohu.edu.tr. FAU - Zorlular, Ali AU - Zorlular A AUID- ORCID: 0000-0003-3791-2399 AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Nigde Omer Halisdemir University, Nigde, Turkey. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20260424 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Cerebral Palsy/rehabilitation MH - Reproducibility of Results MH - Child MH - *Comprehension MH - Surveys and Questionnaires/standards MH - Male MH - Female MH - Generative Artificial Intelligence MH - Large Language Models PMC - PMC13109198 OTO - NOTNLM OT - Artificial intelligence OT - Cerebral palsy OT - ChatGPT OT - Exercise OT - Rehabilitation COIS- Declarations. Conflict of interest: The authors declare no competing interests. EDAT- 2026/04/25 00:34 MHDA- 2026/04/25 00:35 PMCR- 2026/04/24 CRDT- 2026/04/24 23:32 PHST- 2025/11/29 00:00 [received] PHST- 2026/04/17 00:00 [accepted] PHST- 2026/04/14 00:00 [revised] PHST- 2026/04/25 00:35 [medline] PHST- 2026/04/25 00:34 [pubmed] PHST- 2026/04/24 23:32 [entrez] PHST- 2026/04/24 00:00 [pmc-release] AID - 10.1007/s00431-026-06979-3 [pii] AID - 6979 [pii] AID - 10.1007/s00431-026-06979-3 [doi] PST - epublish SO - Eur J Pediatr. 2026 Apr 24;185(5):297. doi: 10.1007/s00431-026-06979-3. PMID- 42032193 OWN - NLM STAT- Publisher LR - 20260424 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Apr 24 TI - Pediatric asthma: positive correlation between platelet-to-HDL-C ratio and blood eosinophil counts. LID - 10.1038/s41390-026-05027-y [doi] AB - BACKGROUND: Current evidence on the association between the platelet-to-high-density lipoprotein cholesterol ratio (PHR) and blood eosinophil counts (BEOC) is limited in pediatric asthma patients. This study aimed to assess the relationship between PHR and BEOC in this population. METHODS: Using data from the National Health and Nutrition Examination Survey (NHANES) from 2009 to 2020, we conducted a cross-sectional study of 2178 eligible participants. Multivariable linear regression (continuous and quartile PHR) analyzed the association, adjusted for key covariates. Dose-response was assessed using restricted cubic splines (RCS), and robustness was tested with stratified and sensitivity analyses. RESULTS: Among 2178 participants (mean age 12.6 +/- 3.9 years; 56.3% male), multivariable linear regression revealed a significant positive correlation between PHR and BEOC (beta = 12.34; 95% CI: 6.53 to 18.15; P < 0.001). RCS analysis indicated a linear relationship (P = 0.905 for nonlinearity). Subgroup analyses were stable across most strata, stronger in females. Sensitivity analyses in the stricter asthma cohort confirmed robustness. CONCLUSIONS: This study reveals a significant, positive association between PHR and BEOC in pediatric asthma patients. PHR may serve as a potential biomarker for pediatric eosinophilic asthma phenotypes, though further prospective studies are needed to confirm its clinical utility. IMPACT: Our study establishes a significant link between platelet-to-high-density lipoprotein cholesterol ratio (PHR) and blood eosinophil counts (BEOC) in pediatric asthma, highlighting PHR as a potential biomarker for eosinophilic asthma phenotypes and expanding the understanding of disease mechanisms in this population. By identifying PHR as an integrated indicator of platelet activation, lipid metabolism, and type 2 immunity, our research bridges gaps in current knowledge and offers new insights for targeted asthma management. These findings have the potential to enhance clinical prediction and management of pediatric asthma by introducing PHR as a novel marker, though further validation is required to solidify its role in routine practice. CI - (c) 2026. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Li, Jingjing AU - Li J AD - College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. AD - Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), Fuzhou, China. FAU - Luo, Fei AU - Luo F AD - College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. AD - Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), Fuzhou, China. FAU - Chen, Lumin AU - Chen L AD - College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. AD - Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), Fuzhou, China. FAU - Lin, Meichai AU - Lin M AD - College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. Meichailin87@163.com. AD - Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), Fuzhou, China. Meichailin87@163.com. LA - eng PT - Journal Article DEP - 20260424 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: The NCHS Institutional Review Board has approved NHANES's investigation, and all participants have provided written informed consent. EDAT- 2026/04/25 00:34 MHDA- 2026/04/25 00:34 CRDT- 2026/04/24 23:29 PHST- 2025/07/17 00:00 [received] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/03/11 00:00 [revised] PHST- 2026/04/25 00:34 [medline] PHST- 2026/04/25 00:34 [pubmed] PHST- 2026/04/24 23:29 [entrez] AID - 10.1038/s41390-026-05027-y [pii] AID - 10.1038/s41390-026-05027-y [doi] PST - aheadofprint SO - Pediatr Res. 2026 Apr 24. doi: 10.1038/s41390-026-05027-y. PMID- 42031488 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 4 DP - 2026 Apr 24 TI - Breastfeeding initiation and continuation among women on medicines: a systematic review and meta-analysis. PG - e107274 LID - 10.1136/bmjopen-2025-107274 [doi] LID - e107274 AB - OBJECTIVES: Breastfeeding provides essential health benefits for infants and mothers, yet initiation and continuation can be influenced by maternal medication use. Uncertainty regarding medication safety may lead to early discontinuation or avoidance of necessary treatment. We conducted a systematic review and meta-analysis to estimate the prevalence of breastfeeding initiation and continuation at 6 months post partum among women using medications. DESIGN: Systematic review and meta-analysis using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. DATA SOURCES: PubMed, Web of Science, Academic Search Premier (EBSCO) and Google Scholar were searched up to 30 November 2024. ELIGIBILITY CRITERIA: For selecting studies: We included cohort, cross-sectional and observational studies reporting breastfeeding initiation at birth and continuation at 6 months post partum among women aged >/=18 years using medications during pregnancy or post partum. Studies reporting medication type and duration of breastfeeding were prioritised. DATA EXTRACTION AND SYNTHESIS: Two independent reviewers screened, extracted and coded data using standardised methods. Risk of bias was assessed using validated tools. Pooled prevalence estimates were calculated using a random effects meta-analysis and meta-regression was performed to explore factors associated with breastfeeding outcomes. Findings were summarised in GRADE evidence profiles and synthesised qualitatively. RESULTS: Of 286 retrieved articles, 29 met the inclusion criteria and 28 were included in the meta-analysis. 14 (48%) were cohort studies reporting breastfeeding prevalence while using medications. The pooled prevalence of breastfeeding initiation among women on medication during pregnancy or post partum was 75.2% (95% CI 69.8% to 80.7%; range 14-98%), with high heterogeneity (I(2)=99.2%, p<0.001). Overall prevalence of breastfeeding at 6 months post partum was 53.2% (95% CI 43% to 63%). Meta-regression showed that women in high-income countries were less likely to initiate (beta=-0.27, 95% CI -0.54 to -0.00, p=0.04) or continue breastfeeding at 6 months (beta=-0.27, 95% CI -0.54 to -0.01, p=0.04). Women using antidepressants (beta=-0.45, 95% CI -0.87 to -0.02, p=0.04) and opioids (beta=-0.50, 95% CI -0.93 to -0.08, p=0.02) were less likely to continue breastfeeding at 6 months. Women living with HIV on ART in low- and middle-income countries had higher continuation rates, likely due to supportive public health programmes. CONCLUSION: Breastfeeding initiation among women using medications is generally high, but continuation declines substantially, particularly among women on psychotropic, opioid or antiepileptic drugs. HIV status, medication type, healthcare support and national guidelines influence breastfeeding outcomes. Targeted interventions, including provider education, medication-specific lactation guidance and supportive workplace policies, are essential to promote sustained breastfeeding among women using medications. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Nakijoba, Ritah AU - Nakijoba R AUID- ORCID: 0000-0002-6626-0329 AD - Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda rnakijoba@idi.co.ug. FAU - Musaazi, Joseph AU - Musaazi J AD - Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda. FAU - Kyohaire, Isabella AU - Kyohaire I AD - Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda. FAU - Atuyambe, Lynn AU - Atuyambe L AD - Department of Community Health and Behavior Sciences, College of Health Sciences, Makerere University, Kampala, Uganda. FAU - Waitt, Catriona AU - Waitt C AD - Infectious Diseases Institute, College of Health Sciences, Makerere University, Kampala, Uganda. AD - Department of Women's and Children's Health, University of Liverpool, Liverpool, UK. FAU - Kiguba, Ronald AU - Kiguba R AUID- ORCID: 0000-0002-2636-4115 AD - Department of Pharmacology and Therapeutics, College of Health Sciences, Makerere University, Kampala, Uganda. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260424 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Female MH - *Breast Feeding/statistics & numerical data MH - Pregnancy MH - Postpartum Period PMC - PMC13110641 OTO - NOTNLM OT - Antibiotics OT - Chronic Disease OT - Drug Therapy OT - Education, Medical OT - Medication Review OT - Postpartum Period COIS- Competing interests: None declared. EDAT- 2026/04/25 00:34 MHDA- 2026/04/25 00:35 PMCR- 2026/04/24 CRDT- 2026/04/24 21:03 PHST- 2026/04/25 00:35 [medline] PHST- 2026/04/25 00:34 [pubmed] PHST- 2026/04/24 21:03 [entrez] PHST- 2026/04/24 00:00 [pmc-release] AID - bmjopen-2025-107274 [pii] AID - 10.1136/bmjopen-2025-107274 [doi] PST - epublish SO - BMJ Open. 2026 Apr 24;16(4):e107274. doi: 10.1136/bmjopen-2025-107274. PMID- 42031231 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260819 IS - 1559-2030 (Electronic) IS - 1551-7144 (Linking) VI - 165 DP - 2026 Jun TI - Design of a multicomponent intervention to reduce the risk of exposure to high concentrations of fluoride in children in Huila, Colombia. PG - 108328 LID - S1551-7144(26)00114-X [pii] LID - 10.1016/j.cct.2026.108328 [doi] AB - INTRODUCTION: Systemic exposure to fluoride represents a significant challenge for global public health. Although it prevents dental caries, prolonged high concentrations affect organs and systems, especially teeth. Despite preventive strategies, evidence of their effectiveness is limited. This protocol describes a randomized controlled trial to evaluate a multicomponent intervention in parents and children that reduces the risk of exposure to high concentrations of fluoride in children. METHODS: Randomized trial in kindergartens in municipalities in the Department of Huila, Colombia. The intervention group will receive a five-component program: installation of water filters to reduce fluoride consumption; educational sessions for parents and children to promote awareness and healthy practices; outreach activities to strengthen collective knowledge; and a maintenance phase for sustainability. The control group will participate in a conventional educational strategy on cariogenic diet, flossing, and hand washing, focused on the parent-child dyad. Measurements will be taken at four points in time: baseline (pre-intervention) and post-intervention at 3, 6, and 12 months. The evaluation will include fluoride concentration in children's urine, levels in water (filter validation), and changes in parental knowledge, attitudes, and practices. DISCUSSION: The trial will evaluate the effectiveness of the multicomponent intervention in reducing fluoride exposure. With comprehensive methodological approaches and objective measurements, it will demonstrate significant improvements in fluoride levels in children and in parental knowledge, attitudes, and practices. It will contribute to child health programs, strengthen preventive strategies in oral health, impact public policy and community health, and open new lines of research on fluoride. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT07232888 Link:https://clinicaltrials.gov/study/NCT07232888. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Garcia-Rojas, Claudia Lorena AU - Garcia-Rojas CL AD - Oral Health Research Group, Antonio Narino University, Bogota, Colombia. Electronic address: claudia_garcia@uan.edu.co. FAU - Perdomo, Alix Katherin Forero AU - Perdomo AKF AD - Faculty of Dentistry, Oral Health Research Group, Antonio Narino University, Bogota, Colombia. FAU - Martinez, Jacqueline Olaya AU - Martinez JO AD - Faculty of Dentistry, Oral Health Research Group, Antonio Narino University, Bogota, Colombia. FAU - Losada-Farfan, Walter AU - Losada-Farfan W AD - University of Tolima, IDEAD, CAT, Neiva, Colombia. FAU - Llanos, Azucena Bocanegra AU - Llanos AB AD - Faculty of Dentistry, Oral Health Research Group, Antonio Narino University, Bogota, Colombia. FAU - Mendez, Yeny Andrea Lebro AU - Mendez YAL AD - Faculty of Dentistry, Oral Health Research Group, Antonio Narino University, Bogota, Colombia. FAU - Robledo, Maria Cecilia Gonzalez AU - Robledo MCG AD - Research on Health Equity, Health Systems Research Center, National Institute of Public Health of Mexico, Cuernavaca, Mexico. FAU - Martinez-Mier, Esperanza Angeles AU - Martinez-Mier EA AD - Department of Dental Public Health and Dental Informatics, Indiana University School of Dentistry, Indiana University, Indianapolis, IN, USA. FAU - Colmenares, Gretel Gonzalez AU - Colmenares GG AD - Faculty of Dentistry, Oral Health Research Group, Antonio Narino University, Bogota, Colombia. LA - eng SI - ClinicalTrials.gov/NCT07232888 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260422 PL - United States TA - Contemp Clin Trials JT - Contemporary clinical trials JID - 101242342 RN - 0 (Cariostatic Agents) RN - Q80VPU408O (Fluorides) SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - Cariostatic Agents MH - Colombia MH - *Dental Caries/prevention & control MH - Fluoridation MH - *Fluorides/analysis/adverse effects/urine MH - *Health Education/organization & administration MH - Health Knowledge, Attitudes, Practice MH - *Parents/education OTO - NOTNLM OT - Enamel fluorosis OT - Fluorides OT - Fluorine OT - Health education (MeSH) OT - Primary prevention COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/25 00:34 MHDA- 2026/05/15 00:31 CRDT- 2026/04/24 19:14 PHST- 2026/01/20 00:00 [received] PHST- 2026/04/20 00:00 [revised] PHST- 2026/04/21 00:00 [accepted] PHST- 2026/05/15 00:31 [medline] PHST- 2026/04/25 00:34 [pubmed] PHST- 2026/04/24 19:14 [entrez] AID - S1551-7144(26)00114-X [pii] AID - 10.1016/j.cct.2026.108328 [doi] PST - ppublish SO - Contemp Clin Trials. 2026 Jun;165:108328. doi: 10.1016/j.cct.2026.108328. Epub 2026 Apr 22. PMID- 42029501 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260424 LR - 20260813 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 11 IP - 2 DP - 2026 Mar 24 TI - Phase-Based Motor Skill Acquisition in Preschool Children with Different Participation Experience in a Kinesiology Program. LID - 10.3390/jfmk11020133 [doi] LID - 133 AB - Background: Early childhood is a critical period for the development of motor competence, which is closely related to later physical activity, educational readiness, and broader developmental outcomes. However, the temporal dynamics of motor skill acquisition in preschool children, particularly the time required to reach initial and early refinement phases of learning, remain insufficiently described. The aim of this study was to examine whether different levels of previous participation experience in an organized kinesiology program are associated with differences in the speed and quality of novel motor skill acquisition in preschool children, and to explore the relationship between baseline motor proficiency and phase-based indicators of motor learning. Methods: A total of 161 preschool children aged 5-6 years participated in the study and were grouped according to their previous participation experience in an organized kinesiology program (0 h, ~120 h, ~350 h, and ~470 h). Following BOT-2 assessment, all participants completed a standardized 7-week motor learning program that included nine previously unfamiliar motor tasks. Using a phase-based video analysis protocol, three learning indicators were recorded: time to Phase 1 (F1; first successful execution), time to Phase 2 (F2; initial refinement of performance), and final performance quality (K). Group differences and associations were first examined descriptively and correlationally, after which additional multivariable regression models were performed to determine whether previous participation experience and baseline motor proficiency were independently associated with motor learning outcomes. Results: The findings showed consistent differences across groups, with children who had greater previous participation experience generally reaching F1 and F2 more rapidly and achieving higher final performance quality scores. Higher BOT-2 scores were also associated with shorter learning times and better final performance quality. In the multivariable models, both previous participation experience in an organized kinesiology program and BOT-2 total score were independently associated with Phase 1 attainment time and final performance quality, whereas only previous participation experience remained independently associated with Phase 2 attainment time. The applied phase-based observational protocol demonstrated good to excellent inter-rater reliability across the evaluated motor learning variables. Conclusions: These findings provide phase-based temporal indicators of motor learning progression in preschool children and suggest that previous participation experience in an organized kinesiology program and baseline motor competence are meaningfully associated with the speed and quality of acquiring new motor tasks. The findings also demonstrate the potential of phase-based approaches for quantifying motor learning dynamics in early childhood settings. Such indicators may offer useful reference information for instructional pacing and the planning of motor learning activities, while also serving as practically relevant predictors for adapting future kinesiology programs to children's motor readiness. Future research should further examine these relationships using longitudinal and analytically expanded designs. FAU - Plazibat, Kristian AU - Plazibat K AUID- ORCID: 0000-0001-7957-5795 AD - Natural Sciences School Vladimir Prelog, 10000 Zagreb, Croatia. AD - Faculty of Educational Sciences, University of Slavonski Brod, 35000 Slavonski Brod, Croatia. AD - Faculty of Kinesiology, University of Zagreb, 10000 Zagreb, Croatia. FAU - Vidranski, Tihomir AU - Vidranski T AD - Faculty of Kinesiology, University of Zagreb, 10000 Zagreb, Croatia. FAU - Baric, Renata AU - Baric R AUID- ORCID: 0000-0003-2614-673X AD - Faculty of Kinesiology, University of Zagreb, 10000 Zagreb, Croatia. LA - eng PT - Journal Article DEP - 20260324 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC13108015 OTO - NOTNLM OT - motor competence OT - motor learning OT - organized kinesiology program OT - phase-based learning OT - preschool children COIS- The authors declare no conflicts of interest. EDAT- 2026/04/24 12:36 MHDA- 2026/04/24 12:37 PMCR- 2026/03/24 CRDT- 2026/04/24 10:43 PHST- 2026/01/30 00:00 [received] PHST- 2026/03/12 00:00 [revised] PHST- 2026/03/20 00:00 [accepted] PHST- 2026/04/24 12:37 [medline] PHST- 2026/04/24 12:36 [pubmed] PHST- 2026/04/24 10:43 [entrez] PHST- 2026/03/24 00:00 [pmc-release] AID - jfmk11020133 [pii] AID - jfmk-11-00133 [pii] AID - 10.3390/jfmk11020133 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2026 Mar 24;11(2):133. doi: 10.3390/jfmk11020133. PMID- 42029001 OWN - NLM STAT- MEDLINE DCOM- 20260904 LR - 20260906 IS - 1601-6343 (Electronic) IS - 1601-6335 (Print) IS - 1601-6335 (Linking) VI - 29 IP - 5 DP - 2026 Oct TI - Functional Unit-Based Analysis Unveils the Skeletal Mandibular Effects of Class II Elastics Therapy in Adolescents. PG - 848-855 LID - 10.1111/ocr.70127 [doi] AB - BACKGROUND: This study sought to thoroughly assess the skeletal impacts of Class II elastics therapy on the developing mandible, highlighting three-dimensional changes in its functional units. METHODS: Treatment records of 140 CBCT scans from 70 adolescent patients were retrospectively collected and assigned to one of two groups: the Class II elastics group (n = 35), in which class II elastics were performed on the stainless steel archwires for more than 12 months, and the control group (n = 35). Pre- and post-treatment cone beam computed tomography (CBCT) images were used to assess changes related to the skeletal facial pattern, functional units, and transverse parameters. An independent t-test was used to compare between the two groups. RESULTS: In the Class II elastics group, the mandibular body unit length (IAF-MF) increased by 3.09 +/- 3.16 mm from pre- to post-treatment, significantly larger than that in the control group (1.37 +/- 3.14 mm). No other mandibular functional unit or transverse parameters demonstrated significant differences between the two groups. CONCLUSIONS: Based on the single-center sample included in this study, the adolescent group receiving prolonged Class II elastics may have exhibited a greater increase in mandibular body unit length compared to the group with minimal elastic use. However, these findings cannot be generalized without further validation. CI - (c) 2026 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Abdulghani, Ehab A AU - Abdulghani EA AUID- ORCID: 0000-0002-3392-4248 AD - State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. AD - Department of Orthodontics, Faculty of Dentistry, Thamar University, Thamar City, Yemen. FAU - Mei, Li AU - Mei L AUID- ORCID: 0000-0001-7856-8091 AD - Discipline of Orthodontics, Department of Oral Sciences, Faculty of Dentistry, University of Otago, Dunedin, New Zealand. FAU - Al-Sosowa, Abeer A AU - Al-Sosowa AA AUID- ORCID: 0000-0003-3318-1381 AD - Department of Periodontology, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Hangzhou, China. AD - Department of Periodontics, Faculty of Dentistry, Thamar University, Thamar, Yemen. FAU - Li, Shijia AU - Li S AUID- ORCID: 0000-0001-8445-6969 AD - State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. FAU - Al-Somairi, Majedh Abdo Ali AU - Al-Somairi MAA AD - Department of Orthodontics, School and Hospital of Stomatology, China Medical University, Shenyang Clinical Medical Research Center of Orthodontic Disease, Shenyang, People's Republic of China. AD - Department of Orthodontics and Dentofacial Orthopedics, Faculty of Dentistry, Ibb University, Ibb, Yemen. FAU - Alhammadi, Maged S AU - Alhammadi MS AUID- ORCID: 0000-0002-1402-0470 AD - Division of Orthodontics and Dentofacial Orthopedics, Department of Preventive Dental Sciences, College of Dentistry, Jazan University, Jazan, Saudi Arabia. FAU - Yi, Jianru AU - Yi J AUID- ORCID: 0000-0003-3594-192X AD - State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. FAU - Li, Yu AU - Li Y AUID- ORCID: 0000-0001-8578-7268 AD - State Key Laboratory of Oral Diseases, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. LA - eng GR - 82371003/National Natural Science Foundation of China/ PT - Journal Article DEP - 20260424 PL - England TA - Orthod Craniofac Res JT - Orthodontics & craniofacial research JID - 101144387 SB - IM MH - Humans MH - *Mandible/growth & development/diagnostic imaging MH - *Malocclusion, Angle Class II/therapy/diagnostic imaging MH - Adolescent MH - Retrospective Studies MH - Cone-Beam Computed Tomography MH - Female MH - Male MH - Cephalometry MH - Orthodontic Appliance Design MH - Orthodontic Wires PMC - PMC13543191 OTO - NOTNLM OT - CBCT OT - adolescent orthodontics OT - class II elastics OT - growth modification OT - mandibular functional unit COIS- The authors declare no conflicts of interest with respect to the authorship and/or publication of this retrospective longitudinal comparative study. EDAT- 2026/04/24 12:35 MHDA- 2026/09/04 17:40 PMCR- 2026/09/04 CRDT- 2026/04/24 08:53 PHST- 2026/04/04 00:00 [revised] PHST- 2026/02/05 00:00 [received] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/09/04 17:40 [medline] PHST- 2026/04/24 12:35 [pubmed] PHST- 2026/04/24 08:53 [entrez] PHST- 2026/09/04 00:00 [pmc-release] AID - OCR70127 [pii] AID - 10.1111/ocr.70127 [doi] PST - ppublish SO - Orthod Craniofac Res. 2026 Oct;29(5):848-855. doi: 10.1111/ocr.70127. Epub 2026 Apr 24. PMID- 42028711 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260820 IS - 2445-2807 (Electronic) IS - 0214-1221 (Linking) VI - 39 IP - 2 DP - 2026 Apr 15 TI - Conservative management of choledocholithiasis in the pediatric age: A safe therapeutic approach. PG - 60-64 LID - 10.54847/cp.2026.02.12 [doi] AB - INTRODUCTION: Gallstone disease is an entity on the rise in the pediatric population, and it is estimated that 20-30% of these patients present with associated choledocholithiasis. Currently, there is no definitive consensus regarding the optimal treatment for pediatric choledocholithiasis, with different therapeutic strategies having been proposed. The objective of the present work is to evaluate the safety and feasibility of conservative management and analyze the factors associated with spontaneous resolution. MATERIAL AND METHODS: Retrospective observational study of 72 pediatric patients with choledocholithiasis treated between 2021 and 2024. Patients with evidence of choledochal dilation (common bile duct >/= 7 mm), biochemical alterations (total bilirubin > 1.2 mg/dl, direct bilirubin > 0.3 mg/dl, amylase > 100 U/L, and/or lipase > 36 U/L) were included. Demographic variables, comorbidities, ultrasound findings, biochemical alterations, and time until resolution were analyzed. RESULTS: The mean age was 12.8 years (range 4-17), with a female predominance (69%). Obesity was the main risk factor (80%). 43.4% of the patients (n= 24) presented with persistent choledocholithiasis and required endoscopic retrograde cholangiopancreatography, with pancreatitis recorded in 3 cases and cholangitis in 1 case as post-procedure complications. 66.6% (n= 48) showed spontaneous resolution. Bilirubin normalization was faster than choledochal diameter normalization (2.6 vs. 4 days). All patients with initial pancreatitis spontaneously resolved their choledocholithiasis. Biliary tract dilation was associated with greater choledocholithiasis persistence (p= 0.0395). CONCLUSIONS: Conservative management with periodic reevaluations constitutes a safe and effective therapeutic alternative in selected pediatric patients, allowing for the reduction of the need for endoscopic retrograde cholangiopancreatography or biliary tract instrumentation and their associated risks. FAU - Dardanelli, C AU - Dardanelli C AD - Pediatric Surgery Department. Hospital General de Ninos Pedro de Elizalde. Buenos Aires (Argentina). FAU - Cotta, E AU - Cotta E AD - Pediatric Surgery Department. Hospital General de Ninos Pedro de Elizalde. Buenos Aires (Argentina). FAU - Pinto, C G AU - Pinto CG AD - Pediatric Surgery Department. Hospital General de Ninos Pedro de Elizalde. Buenos Aires (Argentina). FAU - Falcioni, G AU - Falcioni G AD - Pediatric Surgery Department. Hospital General de Ninos Pedro de Elizalde. Buenos Aires (Argentina). FAU - Toselli, L AU - Toselli L AD - Pediatric Surgery Department. Hospital General de Ninos Pedro de Elizalde. Buenos Aires (Argentina). FAU - Maricic, M AU - Maricic M AD - Pediatric Surgery Department. Hospital General de Ninos Pedro de Elizalde. Buenos Aires (Argentina). FAU - Pace, R AU - Pace R AD - Pediatric Surgery Department. Hospital General de Ninos Pedro de Elizalde. Buenos Aires (Argentina). FAU - Cusumano, H AU - Cusumano H AD - Pediatric Surgery Department. Hospital General de Ninos Pedro de Elizalde. Buenos Aires (Argentina). FAU - Bellia Munzon, G AU - Bellia Munzon G AD - Pediatric Surgery Department. Hospital General de Ninos Pedro de Elizalde. Buenos Aires (Argentina). LA - eng LA - spa PT - Journal Article PT - Observational Study TT - Manejo conservador de la coledocolitiasis en la edad pediatrica: Un enfoque terapeutico seguro. DEP - 20260415 PL - Spain TA - Cir Pediatr JT - Cirugia pediatrica : organo oficial de la Sociedad Espanola de Cirugia Pediatrica JID - 8900492 SB - IM MH - Humans MH - *Choledocholithiasis/therapy MH - Female MH - Retrospective Studies MH - *Conservative Treatment/methods/adverse effects MH - Male MH - Child MH - Child, Preschool MH - Adolescent MH - Cholangiopancreatography, Endoscopic Retrograde/methods MH - Risk Factors MH - Feasibility Studies OTO - NOTNLM OT - Cholangiopancreatography, endoscopic retrograde OT - Cholecystectomy, laparoscopic OT - Choledocholithiasis OT - Conservative treatment OT - Pediatrics EDAT- 2026/04/24 12:35 MHDA- 2026/04/24 12:36 CRDT- 2026/04/24 06:03 PHST- 2026/04/24 12:36 [medline] PHST- 2026/04/24 12:35 [pubmed] PHST- 2026/04/24 06:03 [entrez] AID - 10.54847/cp.2026.02.12 [doi] PST - epublish SO - Cir Pediatr. 2026 Apr 15;39(2):60-64. doi: 10.54847/cp.2026.02.12. PMID- 42027920 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260926 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - The association between motor coordination, physical fitness, and cognitive function in preschool children: physical fitness as a key bridge between motor coordination and executive function. PG - 1795664 LID - 10.3389/fpubh.2026.1795664 [doi] LID - 1795664 AB - The preschool period (3-6 years) is a critical window for the development of motor abilities, physical fitness, and executive function. Objective: This study aimed to investigate the association between motor coordination (MC) and physical fitness (PFI), examine their independent predictive effects on three core executive functions (cognitive flexibility, inhibitory control, working memory), and verify the mediating role of PFI. METHODS: A cross-sectional study was conducted with children aged 3-6 years. Motor coordination (MC) was assessed using the MABC-2, physical fitness (PFI) via the Chinese National Physical Fitness Measurement Standards Manual for Preschool Children, and cognitive functions through validated behavioral tasks. Pearson correlation, hierarchical regression, and Bootstrap mediation analyses were employed. RESULTS: A total of 713 children (386 boys, 327 girls) were included in the analysis. MC was significantly correlated with PFI (r = 0.443, p < 0.01). Both MC and PFI were positively correlated with all cognitive functions (rs: 0.145-0.250). Regression analysis showed MC and PFI independently predicted cognitive flexibility (beta_MC = 0.141, p = 0.001; beta_PFI = 0.106, p = 0.015) and inhibitory control (beta_MC = 0.120, p = 0.003; beta_PFI = 0.098, p = 0.025). Only PFI predicted working memory (beta = 0.093, p = 0.035). PFI significantly mediated the relationship between MC and all cognitive functions, acting as a complete mediator for working memory (indirect effect: 46.9%), and a partial mediator for cognitive flexibility (28.7%) and inhibitory control (31.5%). CONCLUSION: The findings support the "Motor Coordination --> Physical Fitness --> Cognitive Function" pathway, highlighting PFI's key mediating role. Integrated early interventions combining motor skill training and fitness enhancement are recommended to synergistically promote cognitive development. CI - Copyright (c) 2026 Zhang, Zhao, Chen, Zhang, Wang, Chen, Hu and Zhang. FAU - Zhang, Hejie AU - Zhang H AD - China Institute of Sport Science, Beijing, China. FAU - Zhao, Deqiang AU - Zhao D AD - China Institute of Sport Science, Beijing, China. FAU - Chen, Xiaoxiao AU - Chen X AD - School of Physical Education and Sports Rehabilitation, Jinzhou Medical University, Jinzhou, Liaoning, China. FAU - Zhang, Aoyu AU - Zhang A AD - Tianshi College of Tianjin, School of Medicine, Tianjin, China. FAU - Wang, Chunmiao AU - Wang C AD - China Institute of Sport Science, Beijing, China. FAU - Chen, Jiaxin AU - Chen J AD - China Institute of Sport Science, Beijing, China. FAU - Hu, Haixia AU - Hu H AD - Aiyoudong Children and Youth Sports Health Research Institute, Wei fang, Shandong, China. FAU - Zhang, Yanfeng AU - Zhang Y AD - China Institute of Sport Science, Beijing, China. LA - eng PT - Journal Article DEP - 20260408 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Physical Fitness/physiology MH - *Executive Function/physiology MH - Male MH - Cross-Sectional Studies MH - *Cognition/physiology MH - Female MH - Child, Preschool MH - *Motor Skills/physiology MH - Child MH - Cognitive Flexibility MH - *Psychomotor Performance/physiology PMC - PMC13099747 OTO - NOTNLM OT - cognitive function OT - mediation effect OT - motor coordination OT - physical fitness OT - preschool children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/24 12:20 MHDA- 2026/04/24 12:21 PMCR- 2026/04/08 CRDT- 2026/04/24 04:52 PHST- 2026/01/25 00:00 [received] PHST- 2026/03/15 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/04/24 12:21 [medline] PHST- 2026/04/24 12:20 [pubmed] PHST- 2026/04/24 04:52 [entrez] PHST- 2026/04/08 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1795664 [doi] PST - epublish SO - Front Public Health. 2026 Apr 8;14:1795664. doi: 10.3389/fpubh.2026.1795664. eCollection 2026. PMID- 42027743 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260424 LR - 20260813 IS - 2667-3681 (Electronic) IS - 2667-3681 (Linking) VI - 18 DP - 2026 Jun TI - Association of front-of-package warning label perceptions with Mediterranean diet adherence after bariatric surgery: FOP perceptions and MedDiet adherence post-bariatric surgery. PG - 100266 LID - 10.1016/j.obpill.2026.100266 [doi] LID - 100266 AB - BACKGROUND: Front-of-package (FOP) warning labels are intended to support healthier food choices; however, evidence on how patients perceive these warnings after bariatric surgery and how such perceptions relate to dietary quality is limited. We examined the association between perceptions of FOP warning labels and Mediterranean diet (MedDiet) adherence among adults after bariatric surgery in Lima, Peru. METHODS: This was an observational, analytical, cross-sectional study of 200 adults (18-59 years) attending postoperative follow-up at a private clinic in Lima, Peru. MedDiet adherence was assessed using the KIDMED index (originally developed for children/adolescents and used here as a proxy measure of MedDiet-aligned behaviors), and perceptions/understanding of FOP octagonal warnings were measured using a previously validated Peruvian questionnaire. Associations were evaluated using bivariate analyses and multivariable logistic regression, reporting adjusted odds ratios (aOR) and 95% confidence intervals (CI). RESULTS: In adjusted models, higher self-reported preference for salty foods (aOR = 0.261; 95% CI: 0.136-0.501) and sweet foods (aOR = 0.490; 95% CI: 0.263-0.913) were associated with lower odds of medium/high MedDiet adherence. Greater agreement with the statement "I would follow the octagons, but nobody guides me on how to use them" was associated with higher odds of medium/high MedDiet adherence (aOR = 1.289; 95% CI: 1.002-1.659). CONCLUSION: Among adults after bariatric surgery, taste-preference indicators and perceptions regarding FOP warning labels were independently associated with MedDiet adherence. Given the cross-sectional design, these findings should be interpreted as associations rather than causal relationships and highlight the need to strengthen label literacy during postoperative nutrition education. CI - (c) 2026 The Authors. Published by Elsevier Inc. on behalf of Obesity Medicine Association. FAU - Milian, Sila Maribel Laboriano AU - Milian SML AD - Unidad de Salud Publica, Escuela de Posgrado, Universidad Peruana Union, Lima, Peru. FAU - Ruiz, Lesly Pamela Palomino AU - Ruiz LPP AD - Unidad de Salud Publica, Escuela de Posgrado, Universidad Peruana Union, Lima, Peru. FAU - Morales-Garcia, Wilter C AU - Morales-Garcia WC AD - Direccion General de Investigacion, Universidad Peruana Union, Lima, Peru. FAU - Calizaya-Milla, Yaquelin E AU - Calizaya-Milla YE AD - Research Group for Nutrition and Lifestyle, Escuela de Nutricion Humana, Facultad de ciencias de la Salud, Universidad Peruana Union, Lima, 15, Peru. LA - eng PT - Journal Article DEP - 20260414 PL - United States TA - Obes Pillars JT - Obesity pillars JID - 9918697364706676 PMC - PMC13101637 OTO - NOTNLM OT - Bariatric surgery OT - Dietary adherence OT - Front-of-package warning labels OT - Mediterranean diet OT - Obesity COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/24 12:20 MHDA- 2026/04/24 12:21 PMCR- 2026/04/14 CRDT- 2026/04/24 04:50 PHST- 2025/12/01 00:00 [received] PHST- 2026/04/10 00:00 [revised] PHST- 2026/04/10 00:00 [accepted] PHST- 2026/04/24 12:21 [medline] PHST- 2026/04/24 12:20 [pubmed] PHST- 2026/04/24 04:50 [entrez] PHST- 2026/04/14 00:00 [pmc-release] AID - S2667-3681(26)00022-7 [pii] AID - 100266 [pii] AID - 10.1016/j.obpill.2026.100266 [doi] PST - epublish SO - Obes Pillars. 2026 Apr 14;18:100266. doi: 10.1016/j.obpill.2026.100266. eCollection 2026 Jun. PMID- 42027723 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260424 LR - 20260813 IS - 1178-7007 (Print) IS - 1178-7007 (Electronic) IS - 1178-7007 (Linking) VI - 19 DP - 2026 TI - Vitamin D Metabolite Ratios and Association with Type 2 Diabetes Mellitus in a Youth Saudi Population. PG - 597635 LID - 10.2147/DMSO.S597635 [doi] LID - 597635 AB - PURPOSE: Vitamin D deficiency is highly prevalent in Saudi Arabia and has been associated with type 2 diabetes mellitus (T2DM). The vitamin D metabolite ratio (VMR), defined as the ratio of 24,25-dihydroxyvitamin D(3) [24,25(OH)(2)D(3)] to 25-hydroxyvitamin D(3) [25(OH)D(3)], may provide a more functional assessment of vitamin D status than total 25(OH)D alone. This study aimed to investigate the associations between vitamin D metabolite ratio and T2DM status in a Saudi youth cohort. PATIENTS AND METHODS: A cross-sectional study was conducted involving 971 Saudi adolescents (age 14.9 +/- 1.7 years), including 864 normoglycemic individuals, 74 with prediabetes, and 33 with T2DM. Serum vitamin D metabolites [25(OH)D(3), 24,25(OH)(2)D(3), and 25(OH)D(2)] were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). The vitamin D metabolite ratio was calculated, and its association with T2DM was assessed using logistic regression analysis adjusted for age and body mass index (BMI). VMR was analyzed both as a continuous variable and dichotomized at <4% versus >/=4%. The 4% threshold was selected based on preliminary data from adult populations and exploratory analysis of our data distribution, recognizing that this threshold requires validation in adolescent cohorts. RESULTS: Lower VMR (<4%) was associated with higher odds of T2DM (OR: 4.7, 95% CI: 1.1-20.0, p = 0.036), though the wide confidence interval reflects the small T2DM sample size (n=33). Preliminary analysis indicated that VMR may be associated with T2DM in Saudi adolescents, but findings should be interpreted cautiously given the small T2DM sample and cross-sectional design. Larger prospective studies are needed to confirm these preliminary observations. CONCLUSION: A lower vitamin D metabolite ratio is associated with T2DM among Saudi adolescents. VMR may provide complementary information beyond total 25(OH)D; however, formal comparative predictive analyses were not performed, underscoring the importance of proper vitamin D metabolism in glucose homeostasis. However, given the cross-sectional design and small T2DM sample size, these findings are preliminary and require validation in larger prospective studies. CI - (c) 2026 Yakout et al. FAU - Yakout, Sobhy M AU - Yakout SM AD - Chair for Biomarkers of Chronic Diseases, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia. FAU - Hussain, Syed D AU - Hussain SD AD - Chair for Biomarkers of Chronic Diseases, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia. FAU - Alnaami, Abdullah M AU - Alnaami AM AD - Chair for Biomarkers of Chronic Diseases, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia. FAU - Al-Daghri, Nasser M AU - Al-Daghri NM AUID- ORCID: 0000-0001-5472-1725 AD - Chair for Biomarkers of Chronic Diseases, Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260418 PL - New Zealand TA - Diabetes Metab Syndr Obes JT - Diabetes, metabolic syndrome and obesity : targets and therapy JID - 101515585 PMC - PMC13101821 OTO - NOTNLM OT - LC-MS/MS OT - glucose dysregulation OT - impaired fasting glucose OT - vitamin D hydroxylation OT - vitamin D metabolism OT - youth population COIS- The author(s) report no conflicts of interest in this work. EDAT- 2026/04/24 12:20 MHDA- 2026/04/24 12:21 PMCR- 2026/04/18 CRDT- 2026/04/24 04:49 PHST- 2026/01/28 00:00 [received] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/04/24 12:21 [medline] PHST- 2026/04/24 12:20 [pubmed] PHST- 2026/04/24 04:49 [entrez] PHST- 2026/04/18 00:00 [pmc-release] AID - 597635 [pii] AID - 10.2147/DMSO.S597635 [doi] PST - epublish SO - Diabetes Metab Syndr Obes. 2026 Apr 18;19:597635. doi: 10.2147/DMSO.S597635. eCollection 2026. PMID- 42027561 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260424 LR - 20260921 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Reducing relapse in children after recovery from severe acute malnutrition in Mali: participatory development of a theory of change for post-treatment monitoring including SQ-LNS supplementation. PG - 1765714 LID - 10.3389/fnut.2026.1765714 [doi] LID - 1765714 AB - INTRODUCTION: Up to 76% of children treated for acute malnutrition relapse within 6 months from discharge. Despite its known negative impact on children's health and the drain on health system's scarce resources, few studies have explored ways to reduce relapse. In order to design an intervention that can work, there is a need to thoroughly understand the drivers of relapse in a context. OBJECTIVE: We aimed to develop a robust theory of change (ToC) for how relapse can be reduced in Mali and propose an intervention package that is feasible for the health system to adopt with minimal external support. METHODS: We applied a four-step approach to develop the ToC including: (1) An evidence review of potential drivers of malnutrition and relapse locally, based on surveys, gray literature and scientific articles, (2) Schematization of the most important immediate and underlying causes of relapse based on step 1 in a problem tree style and development of a ToC for a program that aims to address the causes, (3) Validation of the ToC with local stakeholders, and (4) Identification of facilitators, barriers and assumptions. Most work was done through on-line workshops including participants from local Ministry of Health (MoH), a local university (USTTB) and both global and local IRC nutrition staff. One in-person workshop was organized with local stakeholders from technical partners and different levels of local health authorities to finalize the ToC. RESULTS: Three direct causes of relapse were identified: (1) Inadequate initial treatment, (2) Inadequate dietary intake post-discharge, and (3) Frequent illness episodes combined with inadequate treatment seeking. To reduce relapse post-treatment, three aims were identified: (1) Improving initial acute malnutrition treatment, (2) Improving nutritional intake after discharge, (3) Decreasing incidence of illness and increasing use of health services. The proposed intervention was built around a program for the post-treatment monitoring of children at the treatment sites including health checks and the provision of small-quantity lipid-based nutrient supplements for children. Inputs included initial and on-going training, supplies and equipment, and supervision and coordination. CONCLUSION: The development of a comprehensive ToC to prevent relapse allowed us to design an intervention that tackles the key perceived and evidenced drivers of relapse in the context. This ToC will underpin a process evaluation that will need to accompany an impact evaluation to determine if and how the intervention reduces relapse. CI - Copyright (c) 2026 Kangas, Coulibaly, Diassana, Traore, Haidara, Cichon, Kodish and Heymsfield. FAU - Kangas, Suvi T AU - Kangas ST AD - International Rescue Committee, Brussels, Belgium. FAU - Coulibaly, Issa Niamanto AU - Coulibaly IN AD - International Rescue Committee, Bamako, Mali. FAU - Diassana, Koniba AU - Diassana K AD - International Rescue Committee, Bamako, Mali. FAU - Traore, Mamadou Zie AU - Traore MZ AD - International Rescue Committee, Bamako, Mali. FAU - Haidara, Alhousseyni AU - Haidara A AD - International Rescue Committee, Bamako, Mali. FAU - Cichon, Bernardette AU - Cichon B AD - International Rescue Committee, London, United Kingdom. FAU - Kodish, Stephen R AU - Kodish SR AD - Pennsylvanla State University, University Park, PA, United States. FAU - Heymsfield, Grace AU - Heymsfield G AD - International Rescue Committee, New York, NY, United States. LA - eng PT - Journal Article DEP - 20260408 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 EIN - Front Nutr. 2026 May 12;13:1863256. doi: 10.3389/fnut.2026.1863256. PMID: 42206088 PMC - PMC13099773 OTO - NOTNLM OT - Mali OT - SQ-LNS small-quantity lipid-based nutrient supplements OT - acute malnutrition OT - relapse OT - severe acute malnutrition (SAM) OT - theory of change (ToC) COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/24 12:20 MHDA- 2026/04/24 12:21 PMCR- 2026/04/08 CRDT- 2026/04/24 04:47 PHST- 2025/12/11 00:00 [received] PHST- 2026/03/13 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/04/24 12:21 [medline] PHST- 2026/04/24 12:20 [pubmed] PHST- 2026/04/24 04:47 [entrez] PHST- 2026/04/08 00:00 [pmc-release] AID - 10.3389/fnut.2026.1765714 [doi] PST - epublish SO - Front Nutr. 2026 Apr 8;13:1765714. doi: 10.3389/fnut.2026.1765714. eCollection 2026. PMID- 42026796 OWN - NLM STAT- MEDLINE DCOM- 20261012 LR - 20261012 IS - 2977-0262 (Electronic) IS - 2977-0254 (Linking) VI - 22 IP - 3 DP - 2026 Oct 13 TI - Rugby as a health and well-being intervention for young people in custody: reflections from a German youth correctional facility (JA Hameln). PG - 429-438 LID - 10.1108/IJOPH-01-2026-0008 [doi] AB - PURPOSE: This study aims to examine a rugby-based health and well-being intervention for young men in custody in a German youth correctional facility in Hameln (JA Hameln), with particular attention to feasibility, psychosocial well-being, emotional regulation and social cohesion. DESIGN/METHODOLOGY/APPROACH: The study reports on two implementation cycles of the same programme model conducted in 2024 and 2025 at JA Hameln. Each cycle consisted of two 90-min sessions per week delivered by trauma-informed coaches (Cycle 1:6 weeks and Cycle 2:8 weeks). Qualitative evidence was derived from coach field notes, weekly staff reflections and informal participant feedback. Because this was a practice-based service evaluation rather than a controlled outcome study, findings are presented as perceived and observed changes rather than isolated causal effects. FINDINGS: Participants and staff described the programme as feasible and acceptable within the custodial setting. They reported emotional relief, improved mood, stronger cooperation and greater trust within the intervention group. Staff also noted a calmer group climate and fewer behavioural incidents during intervention periods. Rugby appeared to function not only as a physical activity but also as a structured pedagogical medium through which rules, contact, responsibility and cooperation could be rehearsed. PRACTICAL IMPLICATIONS: Rugby may function as a transferable sport-based health-promotion tool in custodial settings when it is embedded in institutional routines, delivered by appropriately trained staff and adapted to local safety and cultural conditions. ORIGINALITY/VALUE: To the best of the authors' knowledge, this is one of the first published practice reports of a structured rugby-based intervention in a German youth correctional facility. The study extends predominantly UK-based prison-sport literature by discussing rugby within a lower-familiarity German context and by linking practical delivery to prison health, salutogenic and trauma-informed perspectives. CI - (c) 2026 Emerald Publishing Limited. FAU - Wittke, Torge-Christian AU - Wittke TC AD - Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany, and School of Sport, Nutrition and Allied Health Professions, Oxford Brookes University, Oxford, UK. LA - eng PT - Journal Article PL - England TA - Int J Prison Health (2024) JT - International journal of prison health JID - 9918769578406676 SB - IM MH - Humans MH - Male MH - Germany MH - Adolescent MH - Psychological Well-Being MH - *Prisons/organization & administration MH - *Correctional Facilities MH - *Prisoners/psychology MH - Health Services for Prisoners MH - *Football/psychology MH - Young Adult MH - *Health Promotion/organization & administration/methods MH - Correctional Facilities Personnel OTO - NOTNLM OT - Prison health OT - Rehabilitation OT - Rugby OT - Sport-based intervention OT - Trauma-informed practice OT - Youth justice EDAT- 2026/04/24 06:33 MHDA- 2026/10/12 11:41 CRDT- 2026/04/24 00:43 PHST- 2026/01/29 00:00 [received] PHST- 2026/04/09 00:00 [revised] PHST- 2026/04/12 00:00 [revised] PHST- 2026/04/12 00:00 [accepted] PHST- 2026/10/12 11:41 [medline] PHST- 2026/04/24 06:33 [pubmed] PHST- 2026/04/24 00:43 [entrez] AID - 1361670 [pii] AID - 10.1108/IJOPH-01-2026-0008 [doi] PST - ppublish SO - Int J Prison Health (2024). 2026 Oct 13;22(3):429-438. doi: 10.1108/IJOPH-01-2026-0008. PMID- 42024471 OWN - NLM STAT- MEDLINE DCOM- 20260629 LR - 20260903 IS - 2473-9537 (Electronic) IS - 2473-9529 (Print) IS - 2473-9529 (Linking) VI - 10 IP - 13 DP - 2026 Jul 14 TI - I-STRONG: an integrative, multicomponent treatment approach for chronic pain in pediatric sickle cell disease. PG - 4617-4629 LID - 10.1182/bloodadvances.2025018952 [doi] AB - Chronic pain affects approximately 20% of adolescents living with sickle cell disease (SCD). There is a critical unmet need for evidence-based interdisciplinary approaches for chronic SCD pain treatment. We aimed to (1) use community engagement to adapt an integrative multicomponent treatment program designed to meet the unique needs of chronic SCD pain (ie, Integrative Strong Body and Mind Training [I-STRONG] for SCD), and (2) optimize feasibility and acceptability of I-STRONG through a proof-of-concept trial. Modifications to an existing cognitive behavioral therapy (CBT) and neuromuscular treatment program for chronic widespread pain were informed by semistructured qualitative interviews with adolescents (aged 12-18 years) with chronic SCD pain (n = 12) and their caregivers (n = 12), community advisory boards, and interdisciplinary experts to develop I-STRONG. I-STRONG is a virtual 8-week, 16-session, group intervention combining CBT and neuromuscular exercise training, co-led by experts in psychology and physical therapy. A pilot clinical trial of I-STRONG (n = 12 adolescents; n = 9 caregivers) was conducted to iteratively optimize intervention feasibility and acceptability. Community engagement strategies informed systematic adaptations for access, engagement, relevance, satisfaction, and sense of belonging to meet the unique needs of youth experiencing chronic SCD pain. Pilot testing demonstrated high levels of feasibility (95% completion, 97% intervention fidelity, 92% retention), moderate to high acceptability, and safety. Over 82% of adolescents reported improvements in pain after treatment and at 3-month follow-up. Preliminary evidence suggests that I-STRONG is a promising approach for management of chronic pain in pediatric SCD. A planned multicenter, randomized controlled trial will evaluate I-STRONG's efficacy for pain reduction. This trial was registered at www.clinicaltrials.gov as #NCT06110754. CI - (c) 2026 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved. FAU - Sil, Soumitri AU - Sil S AUID- ORCID: 0000-0001-7207-0524 AD - Department of Pediatrics, Emory University School of Medicine, Atlanta, GA. AD - Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA. FAU - Mooney, Jan T AU - Mooney JT AUID- ORCID: 0000-0002-5632-4958 AD - Department of Pediatrics, Emory University School of Medicine, Atlanta, GA. AD - Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA. FAU - Adkins, Taylor R AU - Adkins TR AD - Department of Pediatrics, Emory University School of Medicine, Atlanta, GA. AD - Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA. FAU - Sinha, Cynthia AU - Sinha C AD - Department of Pediatrics, Emory University School of Medicine, Atlanta, GA. FAU - Nunez, Maria Anjanette AU - Nunez MA AUID- ORCID: 0009-0009-5624-0461 AD - Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA. FAU - Busbee, Allison AU - Busbee A AD - Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA. FAU - Dampier, Carlton AU - Dampier C AUID- ORCID: 0000-0002-7738-2620 AD - Department of Pediatrics, Emory University School of Medicine, Atlanta, GA. AD - Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA. FAU - Bai, Shasha AU - Bai S AUID- ORCID: 0000-0003-4999-327X AD - Department of Pediatrics, Emory University School of Medicine, Atlanta, GA. FAU - Crosby, Lori E AU - Crosby LE AD - Cincinnati Children's Hospital Medical Center, Cincinnati, OH. AD - University of Cincinnati College of Medicine, Cincinnati, OH. FAU - Thomas, Staci AU - Thomas S AD - Cincinnati Children's Hospital Medical Center, Cincinnati, OH. FAU - Beasley, Katie AU - Beasley K AD - Cincinnati Children's Hospital Medical Center, Cincinnati, OH. FAU - Lang, Amy C AU - Lang AC AUID- ORCID: 0000-0002-1905-8013 AD - Cincinnati Children's Hospital Medical Center, Cincinnati, OH. FAU - Murphy, Bridget AU - Murphy B AUID- ORCID: 0000-0001-7631-264X AD - Cincinnati Children's Hospital Medical Center, Cincinnati, OH. FAU - Williams, Justin AU - Williams J AD - Department of Pediatrics, Emory University School of Medicine, Atlanta, GA. AD - Aflac Cancer and Blood Disorders Center, Children's Healthcare of Atlanta, Atlanta, GA. FAU - Batts, Keenan AU - Batts K AD - Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA. FAU - Kurzhals, Aschli AU - Kurzhals A AD - Cincinnati Children's Hospital Medical Center, Cincinnati, OH. FAU - Quinn, Charles T AU - Quinn CT AUID- ORCID: 0000-0002-2372-2175 AD - Cincinnati Children's Hospital Medical Center, Cincinnati, OH. AD - University of Cincinnati College of Medicine, Cincinnati, OH. FAU - Myer, Gregory D AU - Myer GD AUID- ORCID: 0000-0002-9983-8422 AD - Department of Orthopedics, Emory University School of Medicine, Atlanta, GA. AD - Emory Sports Performance and Research Center, Atlanta, GA. AD - Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology/Emory University, Atlanta, GA. AD - The Micheli Center for Sports Injury Prevention, Norwood, MA. AD - Youth Physical Development Center, Cardiff Metropolitan University, Cardiff, Wales, UK. FAU - Bakshi, Nitya AU - Bakshi N AUID- ORCID: 0000-0002-0876-9506 AD - Department of Pediatrics, Yale University School of Medicine, New Haven, CT. FAU - Kesar, Trisha AU - Kesar T AUID- ORCID: 0000-0001-6436-1487 AD - Department of Rehabilitation Medicine, Emory University School of Medicine, Atlanta, GA. FAU - Kashikar-Zuck, Susmita AU - Kashikar-Zuck S AD - Cincinnati Children's Hospital Medical Center, Cincinnati, OH. AD - University of Cincinnati College of Medicine, Cincinnati, OH. LA - eng SI - ClinicalTrials.gov/NCT06110754 GR - R33 AT012421/AT/NCCIH NIH HHS/United States GR - R61 AT012421/AT/NCCIH NIH HHS/United States PT - Clinical Trial PT - Journal Article PT - Multicenter Study PL - United States TA - Blood Adv JT - Blood advances JID - 101698425 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Anemia, Sickle Cell/complications/therapy MH - *Chronic Pain/therapy/etiology MH - Cognitive Behavioral Therapy/methods MH - Combined Modality Therapy MH - *Pain Management/methods MH - Treatment Outcome PMC - PMC13332005 COIS- Conflict-of-interest disclosure: The institutions with which S.S., J.T.M., L.E.C., T.K., and S.K.-Z. are affiliated receive past, current, and ongoing grant funding from National Institutes of Health, including the National Heart, Lung, and Blood Institute, National Center for Complementary and Integrative Health, National Institute of Neurological Disorders and Stroke, National Institute of Nursing Research, National Institute of Child Health and Human Development, and National Institute of Arthritis and Musculoskeletal and Skin Diseases (grants R03HL164333, R61AT012421, K12NS130673, R01NR020781, M01RR008084, R21HD116484, R01AR070474, T32AR069512, P30AR076316). The institution with which G.D.M. is affiliated receives past, current, and ongoing grant funding from the National Institutes of Health/National Institute of Arthritis and Musculoskeletal and Skin Diseases (grants U01AR067997, R01AR070474, R01AR055563, R01AR076153, R01AR077248, and R61AT012421), the Department of Defense (grant W81XWH22C0062), Department of Veteran's Affairs (CReATE [cartilage regeneration using advanced technologies to enable motion] Motion Center), and the Arthritis Foundation Osteoarthritis Clinical Trial Network. G.D.M. consults with commercial entities to support commercialization strategies but has no direct financial interest in commercialization of the products; has received industry-sponsored research funding (to his institutions) related to injury prevention and sport performance and has current ongoing funding from Arthrex Inc to evaluate anterior cruciate ligament (ACL) surgical treatment optimization strategies; receives author royalties from Human Kinetics and Wolters Kluwer; and is an inventor of biofeedback technologies (patent US11350854B2, Augmented and Virtual Reality for Sport Performance and Injury Prevention Application, approved 6/7/2022, software copyrighted) designed to enhance rehabilitation and prevent injuries, which receives licensing royalties. The remaining authors declare no competing financial interests. EDAT- 2026/04/23 18:34 MHDA- 2026/06/29 22:36 PMCR- 2026/04/27 CRDT- 2026/04/23 12:03 PHST- 2026/04/05 00:00 [accepted] PHST- 2025/11/13 00:00 [received] PHST- 2026/06/29 22:36 [medline] PHST- 2026/04/23 18:34 [pubmed] PHST- 2026/04/23 12:03 [entrez] PHST- 2026/04/27 00:00 [pmc-release] AID - 567942 [pii] AID - 10.1182/bloodadvances.2025018952 [doi] PST - ppublish SO - Blood Adv. 2026 Jul 14;10(13):4617-4629. doi: 10.1182/bloodadvances.2025018952. PMID- 42023625 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2083-8441 (Electronic) IS - 2081-237X (Print) IS - 2083-8441 (Linking) VI - 32 IP - 1 DP - 2026 TI - Determination of a higher hypoglycemic threshold in the insulin tolerance test for children with short stature. PG - 26-31 LID - 57629 [pii] LID - 10.5114/pedm.2026.159674 [doi] AB - The insulin tolerance test (ITT) is the most reliable method for diagnosing growth hormone deficiency (GHD). Our study aimed to determine a new glycemic threshold that allows for an adequate growth hormone (GH) response without increasing the risk of deleterious outcomes. This study was conducted retrospectively on children who were suspected of GHD. There were two groups of children: group 1 (G1) consisted of children who underwent an ITT and reached a hypoglycemic level of 2.2 mmol/l, and group 2 (G2) included those who did not reach biochemical hypoglycemia but exhibited clinical hypoglycemic symptoms, which led to cessation of the test. Our population consisted of 129 patients. The mean nadir blood glucose level was 1.798 +/-0.25 mmol/l in G1, significantly lower than in G2, at 2.57 +/-0.28 mmol/l (p < 10-3). GH in G1 reached a mean peak of 4.71 +/-3.20 ng/ml, significantly lower than in G2 (8.56 +/-5.99 ng/ml) (p = 0.01). Among G1, 86% of the patients presented a GHD, compared to 55.6% in G2. The proportion of somatotrophic deficiency was significantly higher in G1 compared to G2 (p = 0.01). Receiver operating characteristic curve analysis revealed a threshold of 2.44 mmol/l with a sensitivity of 90% and a specificity of 60% (area under the curve = 0.915; confidence interval 95% (0.87-0.96). Based on our findings, we recommend implementing this new threshold when hypoglycemic symptoms are present. This higher threshold offers several benefits, including reduced risk to patients, while maintaining accurate interpretation of the test with good sensitivity and specificity. FAU - Taieb, Ach AU - Taieb A AD - Department of Endocrinology, University Hospital of Farhat Hached, Sousse, Tunisia. AD - Faculty of Medicine, University of Sousse, Tunisia. AD - Laboratory of Exercise Physiology and Pathophysiology (LR19ES09), Sousse, Tunisia. FAU - Maissa, Omrani AU - Maissa O AD - Department of Hospital Hygiene, University Hospital of Farhat Hached, Sousse, Tunisia. FAU - Asma, Ammar AU - Asma A AD - Faculty of Medicine, University of Sousse, Tunisia. AD - Department of Hospital Hygiene, University Hospital of Farhat Hached, Sousse, Tunisia. FAU - Haj Slama, Nassim Ben AU - Haj Slama NB AD - Department of Endocrinology, University Hospital of Farhat Hached, Sousse, Tunisia. AD - Faculty of Medicine, University of Sousse, Tunisia. FAU - Ghachem, Aycha AU - Ghachem A AD - Department of Endocrinology, University Hospital of Farhat Hached, Sousse, Tunisia. AD - Faculty of Medicine, University of Sousse, Tunisia. FAU - Imen, Halloul AU - Imen H AD - Department of Endocrinology, University Hospital of Farhat Hached, Sousse, Tunisia. AD - Faculty of Medicine, University of Sousse, Tunisia. FAU - Wiem, Saafi AU - Wiem S AD - Department of Endocrinology, University Hospital of Farhat Hached, Sousse, Tunisia. AD - Faculty of Medicine, University of Sousse, Tunisia. FAU - Hamza, ElFekih AU - Hamza E AD - Department of Endocrinology, University Hospital of Farhat Hached, Sousse, Tunisia. AD - Faculty of Medicine, University of Sousse, Tunisia. FAU - Ghada, Saad AU - Ghada S AD - Department of Endocrinology, University Hospital of Farhat Hached, Sousse, Tunisia. AD - Faculty of Medicine, University of Sousse, Tunisia. FAU - Hasni, Yosra AU - Hasni Y AD - Department of Endocrinology, University Hospital of Farhat Hached, Sousse, Tunisia. AD - Faculty of Medicine, University of Sousse, Tunisia. LA - eng PT - Journal Article TT - Okreslenie wyzszego progu hipoglikemii w tescie tolerancji insuliny u dzieci z niskim wzrostem. PL - Poland TA - Pediatr Endocrinol Diabetes Metab JT - Pediatric endocrinology, diabetes, and metabolism JID - 101518750 RN - 0 (Blood Glucose) RN - 0 (Insulin) RN - 12629-01-5 (Human Growth Hormone) SB - IM MH - Humans MH - Female MH - Male MH - Retrospective Studies MH - Child MH - *Hypoglycemia/diagnosis/blood MH - *Blood Glucose/analysis MH - *Insulin/administration & dosage MH - *Human Growth Hormone/deficiency MH - Adolescent MH - *Growth Disorders/diagnosis/blood MH - Sensitivity and Specificity PMC - PMC13153761 OTO - NOTNLM OT - GH deficiency. OT - growth hormone OT - hypoglycemia OT - short stature OT - insulin tolerance test COIS- None declared. EDAT- 2026/04/23 12:52 MHDA- 2026/04/23 12:53 PMCR- 2026/03/01 CRDT- 2026/04/23 06:57 PHST- 2026/04/23 12:53 [medline] PHST- 2026/04/23 12:52 [pubmed] PHST- 2026/04/23 06:57 [entrez] PHST- 2026/03/01 00:00 [pmc-release] AID - 57629 [pii] AID - 10.5114/pedm.2026.159674 [doi] PST - ppublish SO - Pediatr Endocrinol Diabetes Metab. 2026;32(1):26-31. doi: 10.5114/pedm.2026.159674. PMID- 42023462 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260826 IS - 1578-2735 (Electronic) IS - 1139-9287 (Print) IS - 1139-9287 (Linking) VI - 54 IP - 2 DP - 2026 Apr 15 TI - Impact of the Interaction Between Screen Time and Activity Interests on Adolescent Depression Risk: Construction of a Predictive Model Based on Machine Learning. PG - 500-515 LID - 10.62641/aep.v54i2.2068 [doi] AB - BACKGROUND: Adolescent depression is an increasing public health concern, with excessive screen time elevating depression risk and activity interests providing protection. However, most studies examine these behaviors separately and rely on limited analytical methods. This study used machine learning (ML) to develop a predictive model and evaluate the combined influence of screen time and activity interests on adolescent mental health. METHODS: A multi-center survey was conducted among adolescents aged 10-14 years in Chongchuan District, Nantong. Depression-related domains were assessed using the Child and Adolescent Mental Health Screening Questionnaire, integrating seven validated scales. A twostage feature-selection strategy identified 11 key predictors. Three ML models (logistic regression [LR], extreme gradient boosting [XGBoost], and categorical boosting [CatBoost]) were trained with an 80:20 stratified split. Class imbalance was addressed using synthetic minority oversampling technique and class-weighting. Model performance and interpretability were evaluated using receiver operating characteristic (ROC) and calibration curves, partial dependence plots, and shapley additive explanations (SHAP) analyses. RESULTS: A total of 2202 valid questionnaires were analyzed. The distribution of depression severity was as follows: safe 59%, mild 17%, moderate 11%, and severe 13%. The integrated questionnaire demonstrated strong reliability (Cronbach's alpha = 0.910) and good construct validity (Kaiser-Meyer-Olkin [KMO] = 0.91; root mean square error of approximation [RMSEA] = 0.049; and comparative fit index [CFI] = 0.859). ROC-Youden analysis confirmed expert-defined cutoffs (29, 32, and 35). Feature selection identified 11 key predictors, with activity interest and psychological functioning consistently ranking highest in importance. Across the three ML models, LR exhibited the best generalizability, XGBoost showed overfitting, and CatBoost achieved balanced performance. SHAP and partial dependence analyses revealed nonlinear screen-time effects and dose-dependent protective effects of activity interest, including the moderation of high screen exposure in severe-risk groups. CONCLUSIONS: This study suggests that ML models can be used to screen adolescents at risk of depression by capturing the combined influence of screen time and activity interests. The model is intended for screening rather than diagnosis and may support school-based early identification, and further validation in clinical contexts is needed. FAU - Mao, Leiming AU - Mao L AD - Nantong Mental Health Center, 226001 Nantong, Jiangsu, China. FAU - He, Ruiqi AU - He R AD - Department of Medical Informatics, School of Medicine, Nantong University, 226001 Nantong, Jiangsu, China. FAU - Zhang, Shike AU - Zhang S AD - Department of Medical Informatics, School of Medicine, Nantong University, 226001 Nantong, Jiangsu, China. FAU - Ge, Yongqian AU - Ge Y AD - Department of Radiology, Affiliated Hospital of Nantong University, 226001 Nantong, Jiangsu, China. FAU - Xu, Entong AU - Xu E AD - Department of Medical Informatics, School of Medicine, Nantong University, 226001 Nantong, Jiangsu, China. FAU - Chen, Yalan AU - Chen Y AD - Department of Medical Informatics, School of Medicine, Nantong University, 226001 Nantong, Jiangsu, China. FAU - Cong, Gujun AU - Cong G AD - Nantong Mental Health Center, 226001 Nantong, Jiangsu, China. FAU - Miao, Haiyan AU - Miao H AD - Nantong Mental Health Center, 226001 Nantong, Jiangsu, China. FAU - Jiang, Yunjie AU - Jiang Y AD - Nantong Mental Health Center, 226001 Nantong, Jiangsu, China. FAU - Zhu, Haijiao AU - Zhu H AD - Nantong Mental Health Center, 226001 Nantong, Jiangsu, China. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260415 PL - Spain TA - Actas Esp Psiquiatr JT - Actas espanolas de psiquiatria JID - 100886502 SB - IM MH - Humans MH - Predictive Learning Models MH - Adolescent MH - *Depression/epidemiology/etiology/diagnosis MH - *Screen Time MH - Female MH - Child MH - Male MH - *Machine Learning MH - Boosting Machine Learning Algorithms MH - Prediction Algorithms PMC - PMC13180681 COIS- The authors declare no conflict of interest. EDAT- 2026/04/23 06:31 MHDA- 2026/04/23 06:32 PMCR- 2026/04/15 CRDT- 2026/04/23 05:32 PHST- 2026/04/23 06:32 [medline] PHST- 2026/04/23 06:31 [pubmed] PHST- 2026/04/23 05:32 [entrez] PHST- 2026/04/15 00:00 [pmc-release] AID - 10.62641/aep.v54i2.2068 [pii] AID - 10.62641/aep.v54i2.2068 [doi] PST - epublish SO - Actas Esp Psiquiatr. 2026 Apr 15;54(2):500-515. doi: 10.62641/aep.v54i2.2068. PMID- 42022718 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260423 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 3 DP - 2026 Mar TI - Tackling Obesity: A Qualitative Exploration of a Whole School Food Policy Guideline. PG - e105629 LID - 10.7759/cureus.105629 [doi] LID - e105629 AB - Introduction Childhood obesity is an ever-increasing public health concern in England. Schools offer a unique opportunity to influence childhood obesity. Children spend a significant proportion of their time at school, and there is an opportunity to equip them with lifelong knowledge and skills whilst they are highly influenced by their environment. This Whole School Food Policy Guideline was designed to help schools make whole system changes to their culture and ethos, promoting healthier eating and life choices for their pupils. This project disseminated the guidelines to all schools in the London Borough of Haringey through the local authority's Public Health team, and its impact was explored. The aim of this project was to develop a cost-effective resource, the Whole School Food Policy Guideline, to assist schools in creating environments that promote healthy life choices. Methods Development involved collaboration with local dietitians, teachers and chefs to combine ideas and resources surrounding healthy school food policies. Draft guidelines were reviewed by all contributors. Once finalised, guidelines were printed into booklets and sent to all Haringey schools in February 2020. Semi-structured telephone interviews were conducted in April 2020 with "Healthy School Leads (HSL)" from three local schools: one primary, one secondary and one special educational needs (SEN) school. The aim was to assess initial impressions of the guideline and its perceived usefulness. The data were thematically analysed, and the resulting themes were validated by both researchers. Results Five main themes emerged during analysis, labelled: "utility", "facilitators", "barriers", "special schools" and "guideline improvements and other resources". The guideline was reported as a useful resource with appropriate suggestions for change. This included being adaptable to the needs of the children with SEN. It was particularly valued as a council-produced document, adding a layer of support when implementing change. Resistance to change from parents, children and staff was reported as a previously encountered barrier to healthy change, and the guidelines' informative tone and authority from professionals were useful to address this. The packed lunch guide was well-received by all interviewees, directly addressing their concerns about the quality of food brought from home. The only implemented change at the point of data collection was that this guide had been sent by one school to parents via email. A common view was the feasibility of the recommended water-only policy. All schools mentioned this initiative; one interviewee felt their existing water-only policy needed to be "tightened up", and both other schools considered introducing this idea. It was found that water-only policies are an easily accepted change in comparison to the emotive and controversial nature of food-based policies, suggesting this change would be easily established. Conclusion The guideline fills a gap in supporting schools implementing changes as a Whole School Approach to improve students' health. Its potential impact depends on integration within current practice. The findings from this study suggest that future efforts should focus on water-only policies, working collaboratively with parents and continuing to engage passionate staff who drive positive, meaningful change within their school. CI - Copyright (c) 2026, Kerins et al. FAU - Kerins, Eve AU - Kerins E AD - Paediatrics and Child Health, University College London, London, GBR. AD - Haematology, Guy's Hospital, London, GBR. FAU - Opstad, Hannah AU - Opstad H AD - Paediatrics, Haringey Council, London, GBR. AD - Paediatrics, St George's Hospital, London, GBR. LA - eng PT - Journal Article DEP - 20260321 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13096704 OTO - NOTNLM OT - childhood obesity OT - children OT - children nutrition OT - food policy guidelines OT - healthy eating OT - local council OT - obesity and overweight OT - schools OT - water-only schools OT - whole school approach COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. UCL Research Ethics Committee issued approval 17211/001. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: Haringey Council contributed ~ pound200 for the printing of the guidelines. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/04/23 12:36 MHDA- 2026/04/23 12:37 PMCR- 2026/03/21 CRDT- 2026/04/23 05:13 PHST- 2026/03/19 00:00 [accepted] PHST- 2026/04/23 12:37 [medline] PHST- 2026/04/23 12:36 [pubmed] PHST- 2026/04/23 05:13 [entrez] PHST- 2026/03/21 00:00 [pmc-release] AID - 10.7759/cureus.105629 [doi] PST - epublish SO - Cureus. 2026 Mar 21;18(3):e105629. doi: 10.7759/cureus.105629. eCollection 2026 Mar. PMID- 42022686 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260423 LR - 20260813 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 3 DP - 2026 Mar TI - Critical Evaluation of the Impact of COVID-19 Pandemic on Child Health and Wellbeing and Suggested Preparedness for Future Pandemics-A Narrative Review. PG - e72073 LID - 10.1002/hsr2.72073 [doi] LID - e72073 AB - BACKGROUND AND AIMS: The immediate and long-term effects of COVID-19 pandemic on the children go beyond just being a viral infection. A child's mental health and psychological issues like irritability, anxiety, sadness, non-attentiveness, attention deficit and hyperactive disorder needed evaluation. Based on these study queries, an investigation was carried out to correlate the psychological state and the emergency measures in children with respect to the health and wellbeing outcomes. METHODS: A web-search across scientific databases like the Web of Science, Scopus and PubMed was undertaken for a situational review through available literature, and derive credible solutions. This narrative review included peer-reviewed articles published between January 2020 and February 2026 in English language, focusing on children wellbeing in wake of the COVID-19 pandemic. After analysing the authenticity and relevance of the literature, 158 articles/data were shortlisted for further analyses. The data were qualitatively validated, synthesised into discrete sections and interpreted in the context of the objective of the study. RESULT: Children particularly in low-economy families were likely to experience violence and abuse if they stayed for long in high-risk settings like refugee settlements for internally displaced community. On the contrary, the children of high-economy families had weight gain issues owing to erratic consumption patterns of high-calorie food (like dairy products and sugar-rich packaged snacks) coupled with restricted or limited physical activities. Their dietary patterns and unhealthy eating habits needed monitoring and restrictions to curb obesity risk in the long run. Elevated stress, anxiety and depression levels in a child may result in cognitive impairment. The possibilities of their getting addicted, developing insomnia and acquiring non-communicable illnesses were aspects to consider. Preventive measures like social distancing, lockdowns and shutdowns and mass vaccination drives had wider and critical long-term impact on the young and adolescent. Formulating workable modalities to identify critical influencing factors of a pandemic and assess the impact on the children and beyond is essential for foolproof solutions to combat future occurrences. CONCLUSION: Identifying the associated risk factors and correlating the emergency measures and psychological health seem essential. The supply of quality food seamlessly to the affected communities and the provision of protective gears for the healthcare workers could help keep the children well-fed and relaxed while ensuring the wellbeing of healthcare workers. Maternal and infant care, child-health services, and life-saving medicines and vaccines would also help ease the pressure. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Mohapatra, Ranjan K AU - Mohapatra RK AUID- ORCID: 0000-0001-7623-3343 AD - Department of Chemistry Government College of Engineering Keonjhar Odisha India. FAU - Sarangi, Ashish K AU - Sarangi AK AUID- ORCID: 0000-0002-5602-4736 AD - Department of Chemistry, School of Applied Sciences Centurion University of Technology and Management R. Sitapur India. FAU - Pattnaik, Gurudutta AU - Pattnaik G AD - School of Pharmacy and Life Sciences Centurion University of Technology and Management R. Sitapur India. FAU - Singh, Puneet K AU - Singh PK AUID- ORCID: 0000-0003-1424-7648 AD - School of Biotechnology, Campus-11 KIIT Deemed-to-be-University Bhubaneswar Odisha India. FAU - Dash, Rasmita AU - Dash R AD - School of Pharmacy and Life Sciences Centurion University of Technology and Management R. Sitapur India. FAU - Kandi, Venkataramana AU - Kandi V AUID- ORCID: 0000-0002-7197-0448 AD - Department of Microbiology Prathima Institute of Medical Sciences Karimnagar Telangana India. FAU - Kutikuppala, L V Simhachalam AU - Kutikuppala LVS AD - Department of General Surgery Dr NTR University of Health Sciences Vijayawada Andhra Pradesh India. FAU - Sahoo, Rudra Narayan AU - Sahoo RN AD - School of Pharmaceutical Sciences Siksha O Anusandhan (Deemed to be University) Bhubaneswar Odisha India. FAU - Mishra, Snehasish AU - Mishra S AUID- ORCID: 0009-0008-2139-0075 AD - School of Biotechnology, Campus-11 KIIT Deemed-to-be-University Bhubaneswar Odisha India. FAU - Mishra, Anita AU - Mishra A AD - QA Lead India RASA AI, ChatOwl Inc. 201 Spear Street, Suite 1100 San Francisco California USA. FAU - Nasker, Sourya Subhra AU - Nasker SS AUID- ORCID: 0000-0002-5020-5595 AD - School of Biotechnology, Campus-11 KIIT Deemed-to-be-University Bhubaneswar Odisha India. FAU - Nayak, Sasmita AU - Nayak S AUID- ORCID: 0000-0002-8663-5802 AD - School of Biotechnology, Campus-11 KIIT Deemed-to-be-University Bhubaneswar Odisha India. FAU - Alrasheed, Hayam A AU - Alrasheed HA AUID- ORCID: 0009-0002-6186-848X AD - Department of Pharmacy Practice, College of Pharmacy Princess Nourah Bint Abdulrahman University Riyadh Saudi Arabia. FAU - Kaabi, Nawal A Al AU - Kaabi NAA AD - College of Medicine and Health Science Khalifa University Abu Dhabi United Arab Emirates. AD - Sheikh Khalifa Medical City, Abu Dhabi Health Services Company (SEHA) Abu Dhabi United Arab Emirates. FAU - Alshengeti, Amer AU - Alshengeti A AD - Department of Pediatrics, College of Medicine Taibah University Al-Madinah Saudi Arabia. AD - Department of Infection Prevention and Control, Prince Mohammad Bin Abdulaziz Hospital National Guard Health Affairs Al-Madinah Saudi Arabia. FAU - Abdulkhaliq, Altaf A AU - Abdulkhaliq AA AUID- ORCID: 0000-0002-8148-1103 AD - Department of Biochemistry, Faculty of Medicine Umm Al-Qura University Makkah Saudi Arabia. FAU - Rabaan, Ali A AU - Rabaan AA AUID- ORCID: 0000-0002-6774-9847 AD - Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare Dhahran Saudi Arabia. AD - College of Medicine Alfaisal University Riyadh Saudi Arabia. AD - Department of Public Health and Nutrition The University of Haripur Haripur Pakistan. FAU - Al-Subaie, Maha F AU - Al-Subaie MF AD - College of Medicine Alfaisal University Riyadh Saudi Arabia. AD - Research Center, Dr. Sulaiman Alhabib Medical Group Riyadh Saudi Arabia. FAU - Alhumaid, Saad AU - Alhumaid S AD - School of Pharmacy University of Tasmania Hobart Australia. FAU - Dhama, Kuldeep AU - Dhama K AD - Division of Pathology, ICAR-Indian Veterinary Research Institute Bareilly Uttar Pradesh India. FAU - Kudrat-E-Zahan, Md AU - Kudrat-E-Zahan M AUID- ORCID: 0000-0001-8159-5293 AD - Department of Chemistry Rajshahi University Rajshahi Bangladesh. LA - eng PT - Journal Article DEP - 20260317 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13098172 OTO - NOTNLM OT - COVID-19 OT - COVID-associated complication OT - child nutrition OT - children OT - mental health OT - yoga COIS- The authors declare no conflicts of interest. EDAT- 2026/04/23 06:32 MHDA- 2026/04/23 06:33 PMCR- 2026/03/17 CRDT- 2026/04/23 05:13 PHST- 2024/09/11 00:00 [received] PHST- 2026/02/20 00:00 [revised] PHST- 2026/03/05 00:00 [accepted] PHST- 2026/04/23 06:33 [medline] PHST- 2026/04/23 06:32 [pubmed] PHST- 2026/04/23 05:13 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - HSR272073 [pii] AID - 10.1002/hsr2.72073 [doi] PST - epublish SO - Health Sci Rep. 2026 Mar 17;9(3):e72073. doi: 10.1002/hsr2.72073. eCollection 2026 Mar. PMID- 42022549 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260423 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Can ethical artificial intelligence aid infant and young child feeding support during conflict? A review of the experience and lessons learned from FHI 360's in Ukraine. PG - 1745609 LID - 10.3389/fnut.2026.1745609 [doi] LID - 1745609 AB - BACKGROUND: The war in Ukraine has disrupted access to maternal and infant nutrition services, intensified commercial milk formula marketing risks, and increased demand for accessible, evidence-based breastfeeding support. To respond, FHI 360 and UNICEF Ukraine deployed Harmony of Parenthood, a closed-domain, ethically governed Artificial Intelligence (AI)-enabled breastfeeding and Infant and Young Child Feeding in Emergencies (IYCF-E) support system, integrated with facility-based counseling and a national mentorship programme for lactation counselors. OBJECTIVES: The aim of this study was to evaluate the feasibility, safety, acceptability, and operational contribution of an AI-enabled hybrid counseling model to continuity and quality of Infant and Young Child Feeding in Emergencies services during protracted conflict, including its integration with facility-based counseling and mentorship systems and its potential influence on caregiver feeding practices and counseling quality. METHODS: A convergent mixed-methods approach triangulated: (1) chatbot analytics (user characteristics, interaction volume, response quality); (2) facility counseling data from four conflict-affected oblasts; (3) structured competency assessments following >600 mentorship visits; and (4) qualitative feedback from caregivers and health workers. Governance, safety, and Code-compliance safeguards were assessed against the World Health Organization (WHO) AI ethics guidance, the Operational Guidance on Infant and Young Child Feeding in Emergencies (OG-IFE), and Ukraine's breastfeeding policies. RESULTS: Between November 2024 and October 2025, 2,066 caregivers generated more than 38,000 chatbot interactions. Ninety-eight percent of answers met accuracy and safety criteria; one hallucination event was detected and corrected through real-time review. Caregivers used the system predominantly during periods of insecurity or when services were inaccessible, valuing its 24-h availability, emotional reassurance, and escalation to human counselors. In parallel, facility data showed improved quality of counseling, strengthened referral pathways, and increases in early initiation and exclusive breastfeeding among women receiving repeated support. Mentorship visits demonstrated competency gains among lactation counselors, enhanced adherence to the Code, and more consistent use of MoH-aligned counseling tools. CONCLUSION: An AI-enabled, human-supervised hybrid model is feasible, acceptable, and safe for sustaining breastfeeding and IYCF-E support during active conflict. When anchored in authoritative guidance and embedded within national systems, AI tools can complement skilled counselors, strengthen continuity of care, and uphold Code-compliant, evidence-based support for mothers and infants. To our knowledge, this is the first documented evaluation of an AI-enabled IYCF-E intervention implemented during an active conflict. CI - Copyright (c) 2026 Iellamo, Rozhenko, Strelchenko-Yankovska, Kalashnyk, Burta, Ekwuluo, Hryshyna, Firsova and Sheremet. FAU - Iellamo, Alessandro AU - Iellamo A AD - FHI 360, Crisis Response and Resilience, Washington, DC, United States. FAU - Rozhenko, Olena AU - Rozhenko O AD - FHI 360 Nutrition, Crisis Response and Resilience Department, Dnipro, Ukraine. FAU - Strelchenko-Yankovska, Yuliia AU - Strelchenko-Yankovska Y AD - FHI 360 Nutrition, Crisis Response and Resilience Department, Dnipro, Ukraine. FAU - Kalashnyk, Nataliia AU - Kalashnyk N AD - FHI 360 Nutrition, Crisis Response and Resilience Department, Dnipro, Ukraine. FAU - Burta, Inna AU - Burta I AD - FHI 360 Nutrition, Crisis Response and Resilience Department, Dnipro, Ukraine. FAU - Ekwuluo, Celestine AU - Ekwuluo C AD - FHI 360 Nutrition, Crisis Response and Resilience Department, Dnipro, Ukraine. FAU - Hryshyna, Yelyzaveta AU - Hryshyna Y AD - FHI 360 Nutrition, Crisis Response and Resilience Department, Dnipro, Ukraine. FAU - Firsova, Oleksandra AU - Firsova O AD - FHI 360 Nutrition, Crisis Response and Resilience Department, Dnipro, Ukraine. FAU - Sheremet, Vitalii AU - Sheremet V AD - FHI 360 Nutrition, Crisis Response and Resilience Department, Dnipro, Ukraine. LA - eng PT - Journal Article DEP - 20260331 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC13097993 OTO - NOTNLM OT - artificial intelligence for health and nutrition OT - breastfeeding counseling OT - breastfeeding in emergencies OT - breastfeeding support OT - complementary feeding in emergencies OT - conflict-affected health and nutrition services OT - digital humanitarian assistance OT - infant and young child feeding in emergencies COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/23 06:32 MHDA- 2026/04/23 06:33 PMCR- 2026/03/31 CRDT- 2026/04/23 05:12 PHST- 2025/11/13 00:00 [received] PHST- 2026/02/24 00:00 [revised] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/04/23 06:33 [medline] PHST- 2026/04/23 06:32 [pubmed] PHST- 2026/04/23 05:12 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - 10.3389/fnut.2026.1745609 [doi] PST - epublish SO - Front Nutr. 2026 Mar 31;13:1745609. doi: 10.3389/fnut.2026.1745609. eCollection 2026. PMID- 42021432 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 1999-6217 (Electronic) IS - 1727-5482 (Linking) VI - 23 IP - 4 DP - 2026 Mar 24 TI - Knowledge And Attitudes Regarding Infant Feeding and Immunization among Pregnant Women Visiting Antenatal Clinics. PG - 619-625 LID - 10.33314/jnhrc.v23i04.4646 [doi] AB - BACKGROUND: Deficits in maternal knowledge and perceptions can lead to suboptimal infant feeding and incomplete immunization, impacting child health. Given a lack of recent data in culturally diverse Eastern Kathmandu, this study explores pregnant women's knowledge and attitudes regarding infant feeding and immunization. METHODS: A cross-sectional study was conducted among pregnant women at antenatal clinics in Eastern Kathmandu (Feb-Mar 2025). Data were collected via a validated, self-administered questionnaire after informed consent. Multivariable logistic regression identified predictors of knowledge and attitudes on infant feeding and immunization. Statistical significance was set at p < 0.05. RESULTS: A total of 371 pregnant women participated. There was high knowledge gap in infant feeding practice 208 (56.1%) and high knowledge in immunization 277 (74.7%). Positive attitudes were observed in 341 (93.2%) intending to exclusively breastfeed and 369 (98.4%) believing immunization is safe. Lower knowledge was linked to younger age (<21 years; AOR 0.27, 95% CI 0.07-0.78) and lack of formal education (AOR 0.22, 95% CI 0.03-0.97 for feeding; AOR 0.11, 95% CI 0.03-0.39 for immunization). Positive attitudes were more common among homemakers (AOR 4.86, 95% CI 2.44-9.93) and women with higher parity (AOR 6.14, 95% CI 2.60-15.61 for third or higher). CONCLUSIONS: The study reveals a significant gap in knowledge regarding infant feeding practices, especially among younger and less educated pregnant women in Eastern Kathmandu. Although attitudes are positive, targeted interventions are needed to address knowledge gaps, especially regarding exclusive breastfeeding. FAU - Adhikari, Santosh AU - Adhikari S AUID- ORCID: 0000-0003-4345-6131 AD - Shankarapur Hospital Pvt. Ltd, Kathmandu, Nepal. FAU - Bhattarai, Tribhuwan AU - Bhattarai T AUID- ORCID: 0009-0002-1732-2084 AD - Province Hospital, Karnali Province, Surkhet. FAU - Karki, Prakriti AU - Karki P AD - 1Shankarapur Hospital Pvt. Ltd, Kathmandu, Nepal. FAU - Kunwar, Kshitij AU - Kunwar K AD - Research and Innovation Foundation Nepal. FAU - Dhakal, Ramesh AU - Dhakal R AD - Shankarapur Hospital Pvt. Ltd, Kathmandu, Nepal. FAU - Bhatta, Lok Raj AU - Bhatta LR AD - Epidemiology and Disease Control Divison, Kathmandu. FAU - Rimal, Sabin AU - Rimal S AUID- ORCID: 0000-0003-1223-2063 AD - Kanti Childrens Hospital, Kathmandu. FAU - Gaire, Manisha AU - Gaire M AUID- ORCID: 0009-0002-6437-790X AD - Chitwan Medical College, Bharatpur. FAU - Nepal, Raj Kumar AU - Nepal RK AD - District Hospital, Shankhuwasabha. FAU - Bhattarai, Srijana AU - Bhattarai S AD - Research and Innovation Foundation Nepal. FAU - Suthar, Praveen AU - Suthar P AD - Parul University, India. LA - eng PT - Journal Article DEP - 20260324 PL - Nepal TA - J Nepal Health Res Counc JT - Journal of Nepal Health Research Council JID - 101292936 SB - IM MH - Humans MH - Female MH - *Health Knowledge, Attitudes, Practice MH - Cross-Sectional Studies MH - Adult MH - Pregnancy MH - Young Adult MH - *Breast Feeding/psychology/statistics & numerical data MH - Nepal MH - *Immunization/psychology MH - Prenatal Care MH - *Pregnant People/psychology MH - Infant MH - Adolescent MH - Surveys and Questionnaires MH - Socioeconomic Factors OTO - NOTNLM OT - Attitude; immunization; infant feeding; knowledge; pregnant women. EDAT- 2026/04/23 06:32 MHDA- 2026/04/23 06:33 CRDT- 2026/04/23 00:58 PHST- 2025/07/19 00:00 [received] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/04/23 06:33 [medline] PHST- 2026/04/23 06:32 [pubmed] PHST- 2026/04/23 00:58 [entrez] AID - 10.33314/jnhrc.v23i04.4646 [doi] PST - epublish SO - J Nepal Health Res Counc. 2026 Mar 24;23(4):619-625. doi: 10.33314/jnhrc.v23i04.4646. PMID- 42021356 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 1476-511X (Electronic) IS - 1476-511X (Linking) VI - 25 IP - 1 DP - 2026 Apr 22 TI - Untargeted plasma lipidomic profiling associated with pediatric metabolic dysfunction-associated steatohepatitis (MASH). LID - 10.1186/s12944-026-02937-y [doi] LID - 144 AB - BACKGROUND: Altered lipid metabolism is central to the pathogenesis of MASH, yet lipidomic data in pediatric populations are limited. We conducted a cross-sectional analysis using high-resolution lipidomics to identify lipid alterations associated with pediatric MASH in youth enrolled in NASH CRN studies. METHODS: Clinical assessments included anthropometrics, lipid panels, liver enzymes, and markers of glucose metabolism. MASLD status was determined by liver biopsy or MRI-PDFF. Plasma untargeted lipidomics was performed using UHPLC-MS/MS. Linear models identified differentially abundant lipids. Network analysis characterized lipid-clinical associations and identified network-informed central lipids to evaluate MASH classification performance. RESULTS: The cohort included 102 participants with MASH (29% Zone 1, 19% Zone 3, 52% Definite) and 58 non-MASH participants (29 MASL and 29 controls). Participants were aged 7-18 years; 77% were male and 58% Hispanic, with a mean BMI Z-score of 2.01 +/- 0.77. Compared with non-MASH participants, those with MASH had higher BMI Z-scores, waist circumference, liver enzymes, insulin resistance markers, and triglycerides, and lower HDL cholesterol (p < 0.05). Lipidomics analysis revealed higher levels of saturated TG species and lower levels of Cer and SM species in participants with MASH (p < 0.05). Network analysis showed greater centrality of insulin resistance markers (fasting insulin, HOMA-IR) among participants with MASH, whereas non-MASH participant networks exhibited broader lipid-clinical connectivities. Adding central lipids [TG(12:0_16:0_18:2), SM(d32:3), TG(50:5)] with a high Eigenvector Centrality Score (ECS) significantly improved MASH classification performance. CONCLUSIONS: Pediatric MASH was associated with plasma lipid remodeling, and network-derived central lipids improved MASH classification performance. These findings highlight the potential of lipid signatures for the noninvasive diagnosis of pediatric MASH and warrant validation in independent, longitudinal cohorts. FAU - Lim, Gahyun AU - Lim G AD - Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA. FAU - Huneault, Helaina E AU - Huneault HE AD - Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA. AD - Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA. FAU - Chen, Chih-Yu AU - Chen CY AD - Emory Integrated Metabolomics and Lipidomics Core, Emory University, Atlanta, GA, USA. FAU - Won, Grey AU - Won G AD - Emory Integrated Metabolomics and Lipidomics Core, Emory University, Atlanta, GA, USA. FAU - Sanchez-Torres, Cristian AU - Sanchez-Torres C AD - Department of Pediatrics, Emory University, Atlanta, GA, USA. FAU - Maner-Smith, Kristal AU - Maner-Smith K AD - Emory Integrated Metabolomics and Lipidomics Core, Emory University, Atlanta, GA, USA. FAU - Vos, Miriam B AU - Vos MB AD - Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA. miriam.vos@msu.edu. AD - Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA. miriam.vos@msu.edu. AD - Department of Pediatrics, Emory University, Atlanta, GA, USA. miriam.vos@msu.edu. AD - Children's Healthcare of Atlanta, Atlanta, GA, USA. miriam.vos@msu.edu. AD - Helen DeVos Children's Hospital, Corewell Health, Grand Rapids, MI, USA. miriam.vos@msu.edu. AD - Department of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Helen DeVos Children's Hospital at Corewell Health, Grand Rapids, MI, USA. miriam.vos@msu.edu. LA - eng PT - Journal Article DEP - 20260422 PL - England TA - Lipids Health Dis JT - Lipids in health and disease JID - 101147696 RN - 0 (Lipids) RN - 0 (Triglycerides) RN - 0 (Biomarkers) RN - 0 (Cholesterol, HDL) SB - IM MH - Humans MH - Male MH - Child MH - *Lipidomics/methods MH - Adolescent MH - Female MH - *Non-alcoholic Fatty Liver Disease/blood/pathology MH - Cross-Sectional Studies MH - Liver/pathology/metabolism MH - *Lipids/blood MH - Lipid Metabolism/genetics MH - Insulin Resistance MH - Triglycerides/blood MH - Biomarkers/blood MH - Cholesterol, HDL/blood MH - Tandem Mass Spectrometry PMC - PMC13235174 OTO - NOTNLM OT - Insulin Resistance OT - Lipidomics OT - Pediatric MASH OT - TG COIS- Declarations. Ethics approval and consent to participate: All participants provided written informed consent and assent for their samples and data to be used for future research. The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Boards of Emory University (Protocol No. 78513) and University of California San Diego (Protocol No. 150741). Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/23 06:32 MHDA- 2026/06/28 10:10 PMCR- 2026/04/22 CRDT- 2026/04/23 00:55 PHST- 2025/12/10 00:00 [received] PHST- 2026/03/21 00:00 [accepted] PHST- 2026/06/28 10:10 [medline] PHST- 2026/04/23 06:32 [pubmed] PHST- 2026/04/23 00:55 [entrez] PHST- 2026/04/22 00:00 [pmc-release] AID - 10.1186/s12944-026-02937-y [pii] AID - 2937 [pii] AID - 10.1186/s12944-026-02937-y [doi] PST - epublish SO - Lipids Health Dis. 2026 Apr 22;25(1):144. doi: 10.1186/s12944-026-02937-y. PMID- 42021183 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2342 (Electronic) IS - 1471-2342 (Linking) VI - 26 IP - 1 DP - 2026 Apr 22 TI - Geometric feature analysis for identifying and characterizing normal variations on chest radiographs. LID - 10.1186/s12880-026-02344-w [doi] LID - 289 AB - PURPOSE: To develop and evaluate a quantitative method using geometric features of anatomical shadows on chest X-rays (CXRs) to identify normal variant cases and to elucidate the factors characterizing these variations. MATERIALS AND METHODS: This study included 548 normal CXRs confirmed by CT within one month. Shadows of six key anatomical structures (trachea, aorta, right atrium, left ventricle, right/left diaphragm domes) were manually labeled. Geometric features-center of gravity (x, y), length (l), and count (c)-were calculated for each label after image standardization. Cases with features (x, y, l) in the upper/lower 2.5% distribution or with label count (c) >/= 2 were defined as normal variants. Associated factors were investigated using corresponding CT images and patient age/BMI. RESULTS: Normal variants were identified in 291/548 cases (53.1%). Analysis of 532 outlier feature instances showed associations with adjacent anatomical structures (41.0%, e.g., vertebrae, pulmonary veins, accessory fissures), spinal curvature/vertebral levels (14.2%, trachea only), and significant correlations with age and/or BMI (44.8%). Age was primarily linked to aortic variations, while BMI correlated more with cardiac and diaphragmatic variations. Notable findings included partial right atrial shadow disappearance near the middle lobe pulmonary vein and a wide normal superior tracheal range (C6-Th2). CONCLUSION: This quantitative geometric feature method successfully identifies and characterizes a wide range of normal variations on CXRs. It effectively linked feature outliers to specific anatomical structures and patient factors like age and BMI. This approach provides a foundation for automated large-scale analysis, potentially enhancing radiological training and diagnostic accuracy. FAU - Fujimoto, Shinichi AU - Fujimoto S AD - Radiological Center, University of Fukui Hospital, Yoshida-gun, 910-1193, Japan. FAU - Hara, Takeshi AU - Hara T AD - Department of Electronic and Computer Engineering, Gifu University, Gifu City, 501-1193, Japan. FAU - Tanaka, Masato AU - Tanaka M AD - Medical Education Support Center, University of Fukui, Yoshida-gun, 910-1193, Japan. FAU - Uesaka, Hideki AU - Uesaka H AD - Medical Education Support Center, University of Fukui, Yoshida-gun, 910-1193, Japan. FAU - Itoh, Harumi AU - Itoh H AD - Department of Electronic and Computer Engineering, Gifu University, Gifu City, 501-1193, Japan. AD - Department of Radiology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-cho, Yoshida-gun, 910-1193, Japan. FAU - Sakai, Toyohiko AU - Sakai T AD - Department of Radiology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-cho, Yoshida-gun, 910-1193, Japan. FAU - Tateishi, Toshiki AU - Tateishi T AD - Radiological Center, University of Fukui Hospital, Yoshida-gun, 910-1193, Japan. FAU - Tsujikawa, Tetsuya AU - Tsujikawa T AD - Department of Radiology, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka-Shimoaizuki, Eiheiji-cho, Yoshida-gun, 910-1193, Japan. awaji@u-fukui.ac.jp. LA - eng GR - JPMJCR21D4/JST, CREST/ PT - Journal Article DEP - 20260422 PL - England TA - BMC Med Imaging JT - BMC medical imaging JID - 100968553 SB - IM MH - Humans MH - *Radiography, Thoracic/methods MH - *Tomography, X-Ray Computed/methods MH - Female MH - Male MH - Adult MH - Middle Aged MH - Reference Values MH - Aged MH - Heart Atria/diagnostic imaging MH - Adolescent MH - *Radiographic Image Interpretation, Computer-Assisted/methods MH - Young Adult MH - Trachea/diagnostic imaging MH - Child MH - Aged, 80 and over MH - Infant MH - Child, Preschool MH - Aorta/diagnostic imaging MH - Diaphragm/diagnostic imaging PMC - PMC13235210 OTO - NOTNLM OT - Anatomical variation OT - Chest radiography OT - Computed tomography OT - Geometric feature analysis OT - Image standardization OT - Normal variation OT - Outlier detection OT - Quantitative analysis COIS- Declarations. Ethics approval and consent to participate: This retrospective study was approved by the Ethics Review Committee of the University of Fukui (Approval number: 20170059), and the requirement for informed consent was waived. The study was conducted in accordance with the relevant guidelines and/or regulations including the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/23 06:32 MHDA- 2026/06/27 18:37 PMCR- 2026/04/22 CRDT- 2026/04/23 00:46 PHST- 2025/06/25 00:00 [received] PHST- 2026/04/06 00:00 [accepted] PHST- 2026/06/27 18:37 [medline] PHST- 2026/04/23 06:32 [pubmed] PHST- 2026/04/23 00:46 [entrez] PHST- 2026/04/22 00:00 [pmc-release] AID - 10.1186/s12880-026-02344-w [pii] AID - 2344 [pii] AID - 10.1186/s12880-026-02344-w [doi] PST - epublish SO - BMC Med Imaging. 2026 Apr 22;26(1):289. doi: 10.1186/s12880-026-02344-w. PMID- 42020613 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Apr 22 TI - Dietary nutrient intake and nutritional status in women with infertility: a cross-sectional study. LID - 10.1038/s41598-026-47490-x [doi] LID - 18726 AB - Infertility affects 17.5% of reproductive-age couples and represents a global health challenge with a complex etiology. While nutritional status and diet are recognized as modifiable factors, evidence in specialized clinical settings remains limited. This study was designed under the hypothesis that dietary nutrient intake is significantly associated with the hormonal and anthropometric profile of women seeking fertility treatment. We aimed to address this gap by analyzing these associations in a well-characterized clinical cohort. A cross-sectional study was conducted with 97 women (aged 18-40 years) diagnosed with infertility at Marina Salud Hospital (Spain) between 2022 and 2024. Dietary intake and body composition were assessed using a validated 137-item FFQ and standardized anthropometric measurements (BIA). Reproductive hormones were analyzed from follicular-phase blood samples. Statistical analyses included Spearman correlations and linear regression models adjusted for total energy intake, physical activity, smoking status, and BMI (p < 0.05). Participants had a mean BMI of 25.5 +/- 5.6 kg/m2, with 23.7% overweight and 17.5% obese. Body fat (35.9 +/- 9.3%) and visceral fat (5.5 +/- 2.3%) percentages exceeded recommended values. Multivariate analysis showed that higher intakes of riboflavin (beta = 0.665, p = 0.042) and calcium (beta = 0.004, p = 0.012) were significantly associated with increased muscle mass percentage. Additionally, vitamin E intake was inversely associated with hip circumference (beta = - 0.773, p = 0.004). Regarding hormonal markers, vitamin E showed a significant inverse association with prolactin levels, which remained robust after adjusting for potential confounders (beta = - 0.501, p = 0.008). No other nutrient-hormone associations reached significance after adjustment. These findings suggest that specific nutrients, such as riboflavin and vitamin E, are associated with a more favorable body composition and hormonal regulation in women with infertility. Although the cross-sectional design limits causal inference, these results highlight potential modifiable targets for personalized nutritional support in reproductive health. Future longitudinal studies are warranted to confirm these exploratory findings. FAU - Martin-Manchado, Laura AU - Martin-Manchado L AD - Department of Nursing, University of Alicante, 03690, Alicante, Spain. FAU - Sanchez-Sansegundo, Miriam AU - Sanchez-Sansegundo M AD - Department of Health Psychology, University of Alicante, 03690, Alicante, Spain. FAU - Zaragoza-Marti, Ana AU - Zaragoza-Marti A AD - Department of Nursing, University of Alicante, 03690, Alicante, Spain. ana.zaragoza@ua.es. AD - Alicante Institute for Health and Biomedical Research (ISABIAL-FISABIO Foundation), 03010, Alicante, Spain. ana.zaragoza@ua.es. FAU - Serrado De La Cruz-Delgado, Veronica AU - Serrado De La Cruz-Delgado V AD - Obstetrics and Gynaecology Service, Hospital Marina Salud de Denia, 03700, Alicante, Spain. FAU - Hurtado-Sanchez, Jose Antonio AU - Hurtado-Sanchez JA AD - Department of Nursing, University of Alicante, 03690, Alicante, Spain. LA - eng PT - Journal Article DEP - 20260422 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - *Nutritional Status MH - Cross-Sectional Studies MH - Adult MH - *Infertility, Female MH - Adolescent MH - Young Adult MH - *Diet MH - Body Composition MH - Body Mass Index MH - Energy Intake PMC - PMC13273031 OTO - NOTNLM OT - Body composition OT - Female infertility OT - Nutrient intake OT - Nutritional status OT - Prolactin OT - Riboflavin OT - Vitamin E COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethics Committee of the Alicante Institute for Health and Biomedical Research (ISABIAL) [CEIm: PI2021/113]. Participants were informed about the study's objectives and characteristics, emphasizing the voluntary nature of their participation and their right to withdraw at any time without consequence. After this explanation, their collaboration was requested, and informed consent was obtained from all participants. Competing interests: The authors declare no competing interests. EDAT- 2026/04/23 00:31 MHDA- 2026/06/28 13:04 PMCR- 2026/04/22 CRDT- 2026/04/22 23:36 PHST- 2025/05/14 00:00 [received] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/06/28 13:04 [medline] PHST- 2026/04/23 00:31 [pubmed] PHST- 2026/04/22 23:36 [entrez] PHST- 2026/04/22 00:00 [pmc-release] AID - 10.1038/s41598-026-47490-x [pii] AID - 47490 [pii] AID - 10.1038/s41598-026-47490-x [doi] PST - epublish SO - Sci Rep. 2026 Apr 22;16(1):18726. doi: 10.1038/s41598-026-47490-x. PMID- 42020345 OWN - NLM STAT- MEDLINE DCOM- 20260913 LR - 20260915 IS - 1471-0528 (Electronic) IS - 1470-0328 (Print) IS - 1470-0328 (Linking) VI - 133 IP - 11 DP - 2026 Oct TI - Antenatal Prediction of Shoulder Dystocia and Birth Trauma Using Routine Maternal and Ultrasound Variables: Retrospective Cohort Study. PG - 1996-2002 LID - 10.1111/1471-0528.70250 [doi] AB - OBJECTIVE: To develop antenatal prediction models for shoulder dystocia and birth trauma using routinely collected maternal and sonographic variables. DESIGN: Retrospective cohort study. SETTING: Single tertiary referral centre in the UK. POPULATION OR SAMPLE: All singleton term liveborn pregnancies delivered between January 2016 and November 2024 with a third-trimester ultrasound performed at or beyond 36 weeks' gestation. METHODS: Multivariable logistic regression was used to develop antenatal prediction models for shoulder dystocia and birth trauma, incorporating maternal characteristics and fetal biometry including abdominal circumference (AC; centile or mm) and estimated fetal weight (EFW; grams or centile). Model performance was assessed using tests for multicollinearity, discrimination (area under the ROC curve, AUC) and calibration. MAIN OUTCOME MEASURES: Shoulder dystocia and birth trauma, the latter defined as a composite of shoulder dystocia, postpartum haemorrhage requiring blood transfusion, caesarean delivery at full dilatation, or hypoxic-ischaemic encephalopathy (HIE >/= 1). RESULTS: A total of 24 334 singleton term pregnancies were included; 432 (1.8%) were complicated by shoulder dystocia and 1210 (5.0%) by birth trauma. The model including maternal characteristics and AC centile demonstrated the best discrimination. For shoulder dystocia, the apparent AUC was 0.706 (95% CI 0.682-0.730); the optimism-corrected AUC after bootstrap validation was 0.699. For birth trauma, the apparent AUC was 0.669 (95% CI 0.654-0.685); the optimism-corrected AUC was 0.665. At a 10% false-positive rate, sensitivity was 31.5% for shoulder dystocia and 22.8% for birth trauma, compared with 20.4% and 14.0%, respectively, using EFW >/= 90th centile. CONCLUSIONS: Antenatal models combining fetal AC centile with maternal risk factors outperform EFW-based thresholds currently used in clinical practice. Although discrimination was modest, the model may be useful for antenatal risk stratification and counselling, rather than as a stand-alone clinical test. Such models may help identify pregnancies at increased risk of delivery-related complications associated with fetal overgrowth and inform future studies evaluating targeted interventions. CI - (c) 2026 The Author(s). BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd. FAU - Schwartz, Anat AU - Schwartz A AUID- ORCID: 0000-0002-0161-8932 AD - Fetal Medicine Unit, St. George's University Hospitals NHS Foundation Trust, London, UK. FAU - Minopoli, Monica AU - Minopoli M AUID- ORCID: 0000-0002-8681-4501 AD - Fetal Medicine Unit, St. George's University Hospitals NHS Foundation Trust, London, UK. FAU - Di Ilio, Chiara AU - Di Ilio C AD - Department of Women's and Child Health Sciences and Public Health, IRCCS A. Gemelli University Polyclinic Foundation, Rome, Italy. FAU - Di Mascio, Daniele AU - Di Mascio D AUID- ORCID: 0000-0002-6560-3393 AD - Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Rome, Italy. FAU - Bhide, Amaranth AU - Bhide A AD - Fetal Medicine Unit, St. George's University Hospitals NHS Foundation Trust, London, UK. AD - Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St. George's University of London, London, UK. FAU - Thilaganathan, Basky AU - Thilaganathan B AUID- ORCID: 0000-0002-5531-4301 AD - Fetal Medicine Unit, St. George's University Hospitals NHS Foundation Trust, London, UK. AD - Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St. George's University of London, London, UK. LA - eng PT - Journal Article DEP - 20260422 PL - England TA - BJOG JT - BJOG : an international journal of obstetrics and gynaecology JID - 100935741 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Shoulder Dystocia/epidemiology/diagnosis MH - Retrospective Studies MH - *Ultrasonography, Prenatal/methods MH - *Birth Injuries/epidemiology/diagnosis MH - Adult MH - Fetal Weight MH - United Kingdom/epidemiology MH - Predictive Value of Tests MH - Infant, Newborn MH - Pregnancy Trimester, Third MH - *Dystocia PMC - PMC13571882 OTO - NOTNLM OT - abdominal circumference OT - birth trauma OT - estimated fetal weight OT - prediction model OT - shoulder dystocia OT - third-trimester ultrasound COIS- The authors declare no conflicts of interest. EDAT- 2026/04/23 00:31 MHDA- 2026/09/13 23:34 PMCR- 2026/09/13 CRDT- 2026/04/22 23:03 PHST- 2026/04/07 00:00 [revised] PHST- 2026/01/08 00:00 [received] PHST- 2026/04/14 00:00 [accepted] PHST- 2026/09/13 23:34 [medline] PHST- 2026/04/23 00:31 [pubmed] PHST- 2026/04/22 23:03 [entrez] PHST- 2026/09/13 00:00 [pmc-release] AID - BJO70250 [pii] AID - 10.1111/1471-0528.70250 [doi] PST - ppublish SO - BJOG. 2026 Oct;133(11):1996-2002. doi: 10.1111/1471-0528.70250. Epub 2026 Apr 22. PMID- 42019936 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260612 IS - 1543-2742 (Electronic) IS - 1526-484X (Linking) VI - 36 IP - 4 DP - 2026 Jul 1 TI - Changes in Water Turnover and Its Components Over One Athletic Season: An Observational Study Among Athletes From Different Sports. PG - 428-442 LID - 10.1123/ijsnem.2025-0120 [doi] AB - BACKGROUND: Water turnover (rH2O) is related to water balance including preformed water intake (WI), metabolic, inspired, and transcutaneous water. Literature is scarce on athletes. This study aimed to estimate and compare rH2O and its components during one athletic season (preparatory and competition phases), adjusting for body composition and energy expenditure (EE). METHODS: This longitudinal observational study included 112 athletes (19.8 +/- 4.9 years, 39 females). Doubly labeled water determined total EE, rH2O, and the remaining components through specific equations. Total body water was determined by deuterium dilution and fat-free mass by the four-compartment model. Resting EE was assessed by indirect calorimetry. RESULTS: During the preparatory phase, male athletes showed higher rH2O [5.03 (0.14) kg/day] compared with females [3.64 (0.19) kg/day, p < .001], even adjusting for body mass (p = .024), but not for fat-free mass, total body water, and EE. Triathletes showed higher values of rH2O after adjustments (p < .05). Over the athletic season, no changes occurred for rH2O or preformed WI within or between sexes or sports, even adjusting for body composition while some changes occurred adjusting for EE (p < .05). Over the season, metabolic water increased (p < .001), while inspired and transcutaneous water showed both increases and reductions (p < .05). A small prevalence ( approximately 16%) of low WI (WI /=200 mg/dL (+51.7 ng/mL), non-HDL-C>/=145 mg/dL (+43.6 ng/mL), remnant-cholesterol >/=30 mg/dL (+49.6 ng/mL), low-density lipoprotein cholesterol (LDL-C) >/=130 mg/dL (+34.1 ng/mL), and triglycerides above cut-offs (+49.2 ng/mL). Similarly, a positive parental history of dyslipidaemia was significantly associated with higher PCSK9 values (+39.9 ng/mL) (p<0.001). CONCLUSIONS: In a cohort of children and adolescents at cardio-metabolic risk, circulating PCSK9 levels were significantly associated with atherogenic lipid fractions, including LDL-C, non-HDL-C, triglycerides, and remnant cholesterol. These findings suggest that PCSK9 may play a broader role in lipid metabolism beyond LDL-C regulation, particularly in relation to triglyceride-rich lipoproteins. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Ruscica, M AU - Ruscica M AD - Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", Universita degli Studi di Milano, Milan, Italy; Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. Electronic address: massimiliano.ruscica@unimi.it. FAU - Tassistro, E AU - Tassistro E AD - Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy. FAU - Rizzuto, A S AU - Rizzuto AS AD - Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. FAU - Macchi, C AU - Macchi C AD - Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", Universita degli Studi di Milano, Milan, Italy. FAU - Orlando, A AU - Orlando A AD - Department of Cardiology, Istituto Auxologico Italiano, IRCCS, San Luca Hospital, Piazzale Brescia 20, Milan, Italy. FAU - Rebora, P AU - Rebora P AD - Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, Italy; Bicocca Center of Bioinformatics, Biostatistics and Bioimaging (B4 Centre), School of Medicine and Surgery, University of Milano-Bicocca, Monza, Italy. FAU - Carugo, S AU - Carugo S AD - Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Clinical Sciences and Community Health, Universita degli Studi di Milano, Milan, Italy. FAU - Parati, G AU - Parati G AD - Department of Cardiology, Istituto Auxologico Italiano, IRCCS, San Luca Hospital, Piazzale Brescia 20, Milan, Italy; Department of Medicine and Surgery, University of Milano-Bicocca, Piazza dell'Ateneo Nuovo 1, Milan, Italy. FAU - Giussani, M AU - Giussani M AD - Department of Cardiology, Istituto Auxologico Italiano, IRCCS, San Luca Hospital, Piazzale Brescia 20, Milan, Italy. FAU - Corsini, A AU - Corsini A AD - Department of Pharmacological and Biomolecular Sciences "Rodolfo Paoletti", Universita degli Studi di Milano, Milan, Italy. FAU - Genovesi, S AU - Genovesi S AD - Department of Cardiology, Istituto Auxologico Italiano, IRCCS, San Luca Hospital, Piazzale Brescia 20, Milan, Italy; Department of Medicine and Surgery, University of Milano-Bicocca, Piazza dell'Ateneo Nuovo 1, Milan, Italy. LA - eng PT - Journal Article DEP - 20260408 PL - Netherlands TA - Nutr Metab Cardiovasc Dis JT - Nutrition, metabolism, and cardiovascular diseases : NMCD JID - 9111474 RN - EC 3.4.21.- (Proprotein Convertase 9) RN - EC 3.4.21.- (PCSK9 protein, human) RN - 0 (Biomarkers) RN - 0 (Lipids) SB - IM MH - Humans MH - Adolescent MH - *Proprotein Convertase 9/blood MH - Child MH - Female MH - Male MH - Biomarkers/blood MH - *Dyslipidemias/blood/diagnosis/epidemiology MH - Italy/epidemiology MH - Risk Assessment MH - Age Factors MH - *Metabolic Syndrome/blood/diagnosis/epidemiology MH - Up-Regulation MH - Lipids/blood MH - Predictive Value of Tests MH - *Cardiovascular Diseases/blood/diagnosis/epidemiology MH - Ambulatory Care Facilities MH - Cross-Sectional Studies OTO - NOTNLM OT - Adolescent OT - Atherogenic lipoproteins OT - Childhood OT - PCSK9 OT - Youth COIS- Declaration of competing interest All the authors have nothing to declare. EDAT- 2026/04/22 00:37 MHDA- 2026/08/06 11:36 CRDT- 2026/04/21 21:53 PHST- 2026/01/25 00:00 [received] PHST- 2026/03/28 00:00 [revised] PHST- 2026/04/06 00:00 [accepted] PHST- 2026/08/06 11:36 [medline] PHST- 2026/04/22 00:37 [pubmed] PHST- 2026/04/21 21:53 [entrez] AID - S0939-4753(26)00216-4 [pii] AID - 10.1016/j.numecd.2026.104754 [doi] PST - ppublish SO - Nutr Metab Cardiovasc Dis. 2026 Sep;36(9):104754. doi: 10.1016/j.numecd.2026.104754. Epub 2026 Apr 8. PMID- 42013728 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 1532-3099 (Electronic) IS - 0266-6138 (Linking) VI - 159 DP - 2026 Aug TI - "Sometimes my body is not mine": Maternal ambivalence, bodily limits, and relational meaning in tandem breastfeeding. PG - 104816 LID - S0266-6138(26)00120-8 [pii] LID - 10.1016/j.midw.2026.104816 [doi] AB - BACKGROUND: Tandem breastfeeding remains understudied in research and is often poorly understood in clinical practice. Greater understanding of its emotional, bodily, and relational dimensions may help health professionals provide more appropriate support. OBJECTIVE: To explore mothers' experiences of tandem breastfeeding, with particular attention to ambivalence, bodily limits, and perceived relational meanings. METHODS: A qualitative descriptive study was conducted with 16 mothers who were currently practising tandem breastfeeding or had stopped within the previous two months. Data were collected through semi-structured online interviews and analyzed using reflexive thematic analysis with an inductive approach. Sociodemographic data were summarized descriptively. FINDINGS: Four interrelated themes emerged: (1) maternal ambivalence and bodily intrusion; (2) critical moments and limits of availability; (3) social judgement and maternal positioning; and (4) meaning-making and personal transformation. Mothers described tandem breastfeeding as a relationally meaningful practice, but also as one marked by bodily saturation, emotional overload, and shifting limits. Feelings of closeness, guilt, exhaustion, and gratitude often coexisted. Participants also described stigmatizing social responses and contradictory professional advice, alongside efforts to protect their autonomy and make sense of the experience. CONCLUSIONS: Tandem breastfeeding was experienced as a complex and meaningful caregiving practice shaped by maternal ambivalence, bodily limits, and relational intentions. Rather than representing contradiction or failure, ambivalence formed part of mothers' ongoing negotiation of care for themselves and their children. IMPLICATIONS FOR PRACTICE: Health professionals should provide evidence-informed, non-judgmental support for mothers practising tandem breastfeeding. This includes acknowledging maternal ambivalence, validating bodily limits, and understanding tandem breastfeeding not only as a feeding practice but also as a relational and emotional experience within the family system. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Catala, Patricia AU - Catala P AD - Department of Psychology, Rey Juan Carlos University, Av. de Atenas, S/N 28922 Alcorcon, Madrid, Spain. Electronic address: patricia.catala@urjc.es. FAU - Arribas, Celia AU - Arribas C AD - Department of Psychology, Rey Juan Carlos University, Av. de Atenas, S/N 28922 Alcorcon, Madrid, Spain. FAU - Penacoba, Cecilia AU - Penacoba C AD - Department of Psychology, Rey Juan Carlos University, Av. de Atenas, S/N 28922 Alcorcon, Madrid, Spain. FAU - Huertas-Vieco, Maria AU - Huertas-Vieco M AD - Department of Psychology, ESCUNI, Av. de Ntra. Sra. de Fatima, 102, Carabanchel 28047 Madrid, Spain. LA - eng PT - Journal Article DEP - 20260414 PL - Scotland TA - Midwifery JT - Midwifery JID - 8510930 SB - IM MH - Humans MH - Female MH - *Breast Feeding/psychology/methods MH - Adult MH - *Mothers/psychology MH - Qualitative Research OTO - NOTNLM OT - Breastfeeding practices OT - Maternal experiences OT - Maternal mental health OT - Qualitative research OT - Sibling relationship OT - Tandem breastfeeding COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: This research received additional support beyond the authors' academic institutions. The study was conducted within the framework of a research project funded through a grant for the realization of research projects (direct subsidy) awarded under the agreement between the Community of Madrid and Rey Juan Carlos University for the promotion and encouragement of research and technology transfer during the period 2023-2026 (Code: 2023/00423/017; Project acronym: I-MARTERNA; Line A: Emerging doctors). The funding body had no role in the study design; data collection, analysis, or interpretation; writing of the manuscript; or the decision to submit the article for publication. The authors declare that there are no other relationships or activities that could be perceived as a conflict of interest in relation to this work. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/22 00:40 MHDA- 2026/05/31 05:33 CRDT- 2026/04/21 18:09 PHST- 2026/02/01 00:00 [received] PHST- 2026/03/25 00:00 [revised] PHST- 2026/04/13 00:00 [accepted] PHST- 2026/05/31 05:33 [medline] PHST- 2026/04/22 00:40 [pubmed] PHST- 2026/04/21 18:09 [entrez] AID - S0266-6138(26)00120-8 [pii] AID - 10.1016/j.midw.2026.104816 [doi] PST - ppublish SO - Midwifery. 2026 Aug;159:104816. doi: 10.1016/j.midw.2026.104816. Epub 2026 Apr 14. PMID- 42013650 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 1878-5506 (Electronic) IS - 1389-9457 (Linking) VI - 144 DP - 2026 Aug TI - Distinct forms of childhood maltreatment and their associations with subjective and objective sleep during pregnancy. PG - 108951 LID - S1389-9457(26)00190-5 [pii] LID - 10.1016/j.sleep.2026.108951 [doi] AB - OBJECTIVES: To examine the associations between distinct forms of childhood maltreatment and subjective/objective sleep during the second trimester of pregnancy. METHODS: Seventy-two pregnant women (n = 42 with an history of childhood maltreatment) were assessed between 18 and 20 weeks of gestation, a period considered relatively stable within pregnancy. Sleep was evaluated using both subjective and objective measures. Subjective sleep was measured using two validated self-report questionnaires, the Pittsburgh Sleep Quality Index and the Epworth Sleepiness Scale. Objective sleep was measured using actigraphy (Mini-Mitter/Respironics) worn on the non-dominant wrist for seven consecutive days, accompanied by daily sleep diaries. Linear regression models were used to test associations between five distinct forms of childhood maltreatment (physical neglect, emotional neglect, physical abuse, emotional abuse, and sexual abuse) and sleep parameters (subjective and objective measures). Analyses were conducted using both dichotomous exposure scores (yes/no based on validated cutoffs) and continuous severity scores. All models simultaneously controlled for other forms of childhood maltreatment types, maternal education and household income. RESULTS: Pregnant women with a history of childhood emotional abuse reported significantly poorer subjective sleep, reflected in a 2-point higher on the Pittsburgh Sleep Quality score (2.0 +/- .9, p = .03) compared to pregnant women without such histories. Objective actigraphy data indicated that pregnant women with a history of childhood sexual abuse obtained approximately 1 h less nighttime sleep (-62.1 +/- 20.3 min, p = .003) compared to pregnant women who did not report childhood sexual abuse. Analyses using continuous severity scores for each childhood maltreatment type yielded consistent findings. CONCLUSIONS: Distinct forms of childhood maltreatment appear to have different associations with subjective and objective sleep during pregnancy. These findings underscore the importance of replication in larger and more diverse samples, as well as the need for studies that monitor sleep across pregnancy to clarify mechanisms and inform trauma-informed approaches to perinatal sleep health. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Touchette, Evelyne AU - Touchette E AD - Department of Psychoeducation, Universite du Quebec a Trois-Rivieres, Quebec, Canada; Centre de recherche universitaire sur les jeunes et les familles, Quebec, Canada; Research Unit on Children's Psychosocial Maladjustment, Quebec, Canada; Centre d'etudes interdisciplinaires sur le developpement de l'enfant et la famille, Universite du Quebec a Trois-Rivieres, Quebec, Canada. Electronic address: Evelyne.Touchette@uqtr.ca. FAU - Zaine, Y-Lane Noemie AU - Zaine YN AD - Centre de recherche universitaire sur les jeunes et les familles, Quebec, Canada; Department of Psychoeducation, Universite de Sherbrooke, Quebec, Canada; Centre de recherche interdisciplinaire sur les problemes conjugaux et les agressions sexuelles, Quebec, Canada. FAU - Garon-Bissonnette, Julia AU - Garon-Bissonnette J AD - Peabody College of Education and Human Development, Vanderbilt University, Nashville, TN, USA. FAU - Lemieux, Roxanne AU - Lemieux R AD - Centre d'etudes interdisciplinaires sur le developpement de l'enfant et la famille, Universite du Quebec a Trois-Rivieres, Quebec, Canada; Centre de recherche interdisciplinaire sur les problemes conjugaux et les agressions sexuelles, Quebec, Canada; Department of Nursing Sciences, Universite du Quebec a Trois-Rivieres, Quebec, Canada. FAU - Berthelot, Nicolas AU - Berthelot N AD - Centre d'etudes interdisciplinaires sur le developpement de l'enfant et la famille, Universite du Quebec a Trois-Rivieres, Quebec, Canada; Centre de recherche interdisciplinaire sur les problemes conjugaux et les agressions sexuelles, Quebec, Canada; Department of Nursing Sciences, Universite du Quebec a Trois-Rivieres, Quebec, Canada. LA - eng PT - Journal Article DEP - 20260407 PL - Netherlands TA - Sleep Med JT - Sleep medicine JID - 100898759 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adult MH - Actigraphy MH - *Sleep Quality MH - Surveys and Questionnaires MH - *Sleep/physiology MH - Self Report MH - Pregnancy Trimester, Second MH - Sleep Duration MH - *Adult Survivors of Child Abuse/psychology MH - *Sleep Wake Disorders MH - *Child Abuse/psychology MH - *Pregnancy Complications/psychology OTO - NOTNLM OT - Actigraphy OT - Epworth sleepiness scale OT - Pittsburgh sleep quality index OT - Sleep OT - Trauma and pregnancy COIS- Declaration of competing interest No conflict of interest has been declared by the authors. EDAT- 2026/04/22 00:35 MHDA- 2026/05/25 06:31 CRDT- 2026/04/21 18:06 PHST- 2025/09/17 00:00 [received] PHST- 2026/03/26 00:00 [revised] PHST- 2026/04/04 00:00 [accepted] PHST- 2026/05/25 06:31 [medline] PHST- 2026/04/22 00:35 [pubmed] PHST- 2026/04/21 18:06 [entrez] AID - S1389-9457(26)00190-5 [pii] AID - 10.1016/j.sleep.2026.108951 [doi] PST - ppublish SO - Sleep Med. 2026 Aug;144:108951. doi: 10.1016/j.sleep.2026.108951. Epub 2026 Apr 7. PMID- 42013442 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260421 LR - 20260813 IS - 2152-7202 (Electronic) IS - 2152-7202 (Linking) VI - 18 DP - 2026 Apr 21 TI - Experiential Classes Plus Digital Logging in Antenatal Care for Pregnant Women in China: Mixed Methods Study. PG - e84705 LID - 10.2196/84705 [doi] LID - e84705 AB - BACKGROUND: Maternal health during the perinatal period is a global public health priority. While antenatal education is widely implemented, conventional lecture-based models often fail to achieve sustained behavior change. Innovative approaches that integrate experiential learning with digital support may enhance maternal knowledge, self-management, and pregnancy outcomes. OBJECTIVE: The aim of this study is to evaluate the feasibility and preliminary effectiveness of a combined experiential class and online logging intervention for pregnant women in China and to explore the mechanisms underpinning its impact on health practices and service experiences. METHODS: A mixed methods design was used in a district-level maternal and child health hospital in Beijing. In the quantitative arm, 40 women (intervention group, n=20; control group, n=20) were enrolled in a quasi-experimental comparison. Outcomes included knowledge-attitude-practice indicators, service satisfaction, and clinical birth outcomes. Given the limited sample size, a qualitative arm was conducted to complement statistical findings: semistructured interviews with 20 women (10 per group) were analyzed thematically. Quantitative and qualitative results were integrated during interpretation to provide a comprehensive evaluation. RESULTS: Compared with the experiential class alone, the combined intervention was associated with higher knowledge scores (mean difference 1.6 points, 95% CI 0.8-2.4), stronger adherence to recommended health practices (composite adherence score difference 1.0, 95% CI 0.4-1.6), and higher overall service satisfaction (mean difference 0.6, 95% CI 0.2-1.0). Across multiple domains, a higher proportion of participants in the intervention group met dietary, exercise, and supplementation recommendations. Clinical outcome differences were exploratory, as the study was not powered for these end points. Qualitative analysis revealed 3 mechanisms, such as empowerment and self-efficacy, practice and persistence, and systemic/environmental support, through which the intervention influenced experiences and practices. CONCLUSIONS: The experiential class plus online logging model is feasible and acceptable in a real-world antenatal setting. Although limited by a small sample size, findings suggest that the intervention improves maternal knowledge, health practices, and service experiences and may inform future adequately powered trials to evaluate pregnancy outcomes. Qualitative insights highlight mechanisms of health practice change and provide contextual depth, underscoring the value of mixed methods designs in maternal health research. CI - (c) Zhenfeng Sun, Fuwen Yang, Xi Wang, Yin Sun, Suhan Zhang, Liangkun Ma. Originally published in Journal of Participatory Medicine (https://jopm.jmir.org). FAU - Sun, Zhenfeng AU - Sun Z AUID- ORCID: 0009-0003-3539-5188 AD - Department of Maternal Health Care, Beijing Daxing District Maternal and Child Health Hospital, Beijing, China. FAU - Yang, Fuwen AU - Yang F AUID- ORCID: 0009-0004-1697-0914 AD - School of Social Sciences, Faculty of Arts and Education, University of Auckland, Auckland, New Zealand. FAU - Wang, Xi AU - Wang X AUID- ORCID: 0000-0001-7427-5427 AD - School of Community and Public Health, Faculty of Health and Environment Sciences, Auckland University of Technology, Auckland, New Zealand. FAU - Sun, Yin AU - Sun Y AUID- ORCID: 0000-0003-2903-5410 AD - Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China, 86 13021961166. FAU - Zhang, Suhan AU - Zhang S AUID- ORCID: 0000-0002-6691-6201 AD - Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China, 86 13021961166. FAU - Ma, Liangkun AU - Ma L AUID- ORCID: 0000-0001-5758-0198 AD - Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing, 100730, China, 86 13021961166. LA - eng PT - Journal Article DEP - 20260421 PL - Canada TA - J Particip Med JT - Journal of participatory medicine JID - 101539422 PMC - PMC13099118 OTO - NOTNLM OT - China OT - antenatal education OT - digital health OT - experiential learning OT - maternal health OT - mixed methods COIS- Conflicts of Interest: The authors declare that they have no conflicts of interest relevant to this manuscript. EDAT- 2026/04/21 18:34 MHDA- 2026/04/21 18:35 PMCR- 2026/04/21 CRDT- 2026/04/21 16:33 PHST- 2025/09/24 00:00 [received] PHST- 2026/01/06 00:00 [revised] PHST- 2026/01/06 00:00 [accepted] PHST- 2026/04/21 18:35 [medline] PHST- 2026/04/21 18:34 [pubmed] PHST- 2026/04/21 16:33 [entrez] PHST- 2026/04/21 00:00 [pmc-release] AID - v18i1e84705 [pii] AID - 84705 [pii] AID - 10.2196/84705 [doi] PST - epublish SO - J Particip Med. 2026 Apr 21;18:e84705. doi: 10.2196/84705. PMID- 42013312 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260917 IS - 1945-7189 (Electronic) IS - 0163-769X (Print) IS - 0163-769X (Linking) VI - 47 IP - 5 DP - 2026 Sep 16 TI - Glycated CD59: a novel biomarker for gestational diabetes. PG - 565-576 LID - 10.1210/endrev/bnag010 [doi] AB - Gestational diabetes mellitus (GDM), defined as glucose intolerance that starts during pregnancy, represents a major public health challenge because it is a major cause of adverse maternal and fetal outcomes and presents a significantly high risk of diabetes, obesity, and cardiovascular disease for both the mother and the infant. The diagnosis of GDM is currently made through oral glucose tolerance tests (OGTT); other markers of glycemic control have notably failed for GDM diagnosis. Since the treatment of GDM reduces the incidence of adverse pregnancy outcomes, screening for GDM with OGTTs in pregnancy weeks 24 to 28 is the standard of care in most nations worldwide. However, universal screening is difficult to achieve due, in part, to the fact that OGTTs are cumbersome and uncomfortable. Thus, the importance of detecting glucose intolerance in pregnant women, the possibility of reducing with treatment the associated risks, the low sensitivity of glycemic markers in pregnancy, and the multiple problems associated with OGTTs highlight the significance of exploring alternative screening/diagnostic methods that are sensitive, accurate, and well-tolerated by patients. In this review, we summarize our discovery, development, and clinical validation in six human studies of plasma glycated CD59 (pGCD59), the glucose-modified form of the key complement inhibitor CD59, as a biomarker for screening, diagnosis, and monitoring of GDM. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Endocrine Society. FAU - Toth Castillo, Michelle AU - Toth Castillo M AD - Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. FAU - Drayton Powell, Shauntina AU - Drayton Powell S AD - Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. FAU - Biermann, Amy AU - Biermann A AD - Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. FAU - Torrey, Julia AU - Torrey J AD - Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. FAU - Luque-Fernandez, Miguel Angel AU - Luque-Fernandez MA AUID- ORCID: 0000-0001-6683-5164 AD - Department of Biostatistics, University of Granada, Granada, Spain. FAU - Halperin, Jose AU - Halperin J AUID- ORCID: 0000-0003-4749-5285 AD - Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. LA - eng GR - DK136617/NH/NIH HHS/United States GR - R01 DK136617/DK/NIDDK NIH HHS/United States GR - DK101442/NH/NIH HHS/United States GR - R01 DK118528/DK/NIDDK NIH HHS/United States GR - R56 DK089206/DK/NIDDK NIH HHS/United States GR - DK095424/NH/NIH HHS/United States GR - DK062294/NH/NIH HHS/United States GR - R01 DK101442/DK/NIDDK NIH HHS/United States GR - DK089206/NH/NIH HHS/United States GR - DK118528/NH/NIH HHS/United States PT - Journal Article PT - Review PL - United States TA - Endocr Rev JT - Endocrine reviews JID - 8006258 RN - 0 (Biomarkers) RN - 0 (CD59 Antigens) RN - 0 (Glycation End Products, Advanced) RN - 101754-01-2 (CD59 protein, human) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Diabetes, Gestational/diagnosis/blood MH - Biomarkers/blood MH - *CD59 Antigens/blood/metabolism MH - Glycation End Products, Advanced MH - Glucose Tolerance Test PMC - PMC13577763 OTO - NOTNLM OT - CD59 and glycated CD59 OT - biomarkers OT - complement system OT - gestational diabetes mellitus OT - pregnancy-induced glucose intolerance EDAT- 2026/04/21 18:33 MHDA- 2026/09/16 03:34 PMCR- 2026/04/21 CRDT- 2026/04/21 15:03 PHST- 2025/05/22 00:00 [received] PHST- 2026/04/16 00:00 [accepted] PHST- 2026/09/16 03:34 [medline] PHST- 2026/04/21 18:33 [pubmed] PHST- 2026/04/21 15:03 [entrez] PHST- 2026/04/21 00:00 [pmc-release] AID - 8660315 [pii] AID - bnag010 [pii] AID - 10.1210/endrev/bnag010 [doi] PST - ppublish SO - Endocr Rev. 2026 Sep 16;47(5):565-576. doi: 10.1210/endrev/bnag010. PMID- 42012888 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261008 IS - 2047-3095 (Electronic) IS - 2047-3087 (Linking) VI - 37 IP - 3 DP - 2026 Jul TI - Mid-range Theory for the Nursing Diagnosis Ineffective Infant Suck-Swallow Response. PG - 311-320 LID - 10.1177/20473087261443264 [doi] AB - PurposeTo develop a mid-range theory for the nursing diagnosis Ineffective infant suck-swallow response.Data SourcesScientific findings were derived from two systematic reviews, one addressing etiological factors and the other focused on clinical indicators. Additional theoretical support from Roy's Adaptation Model guided the categorization of the elements identified in the reviews and the conceptual relationships defined during theory construction.Data SynthesisSeven stimuli and fifteen defining characteristics were identified and classified according to causal hierarchy and behavioral timing. Findings support revising the diagnosis to "Ineffective Infant Suck-Swallow-Breathing Response" and reclassifying it under the Nutrition domain. A pictorial diagram and nine theoretical propositions were developed to depict causal links and guide nursing practice.ConclusionsThe Mid-Range Theory supported revising the nursing diagnosis to "Ineffective Infant Suck-Swallow-Breathe Response," reclassifying it under the Nutrition domain, and refining defining characteristics, at-risk populations, and associated conditions. These adjustments aim to improve diagnostic accuracy and guide targeted neonatal nursing interventions. Further validation studies are recommended.Implications for Nursing PracticeThe proposed revisions can improve diagnostic accuracy, enable early identification of feeding difficulties, and guide targeted neonatal nursing interventions to promote safe and effective feeding. FAU - Calixto Gomes, Samara AU - Calixto Gomes S AUID- ORCID: 0000-0002-7929-3648 AD - Nursing Department, Federal University of Ceara, Fortaleza, Ceara, Brazil. RINGGOLD: 28121 FAU - Butcher, Rita de Cassia Gengo E Silva AU - Butcher RCGES AUID- ORCID: 0000-0002-7307-2203 AD - Christine E. Lynn College of Nursing, Florida Atlantic University, Boca Raton, FL, USA. RINGGOLD: 15801 FAU - Vieira, Lara de Almeida Rocha AU - Vieira LAR AUID- ORCID: 0000-0002-4196-4733 AD - Nursing Department, Federal University of Ceara, Fortaleza, Ceara, Brazil. RINGGOLD: 28121 FAU - Alexandrino da Silva, Leonardo AU - Alexandrino da Silva L AUID- ORCID: 0000-0002-1812-6459 AD - Nursing Department, Federal University of Ceara, Fortaleza, Ceara, Brazil. RINGGOLD: 28121 FAU - Butcher, Howard Karl AU - Butcher HK AUID- ORCID: 0000-0002-8394-516X AD - Christine E. Lynn College of Nursing, Florida Atlantic University, Boca Raton, FL, USA. RINGGOLD: 15801 FAU - Guedes, Nirla Gomes AU - Guedes NG AUID- ORCID: 0000-0003-0405-7517 AD - Nursing Department, Federal University of Ceara, Fortaleza, Ceara, Brazil. RINGGOLD: 28121 LA - eng PT - Journal Article PT - Systematic Review DEP - 20260421 PL - United States TA - Int J Nurs Knowl JT - International journal of nursing knowledge JID - 101582422 SB - IM MH - Humans MH - Infant MH - Infant, Newborn MH - *Deglutition MH - *Nursing Diagnosis MH - *Nursing Theory MH - *Sucking Behavior OTO - NOTNLM OT - Infant OT - degluticao OT - diagnostico de enfermagem OT - lactente OT - middle-range theory OT - nursing diagnosis OT - sucking OT - succao OT - swallowing OT - teoria de medio alcance COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/04/21 18:33 MHDA- 2026/10/07 17:33 CRDT- 2026/04/21 12:03 PHST- 2026/10/07 17:33 [medline] PHST- 2026/04/21 18:33 [pubmed] PHST- 2026/04/21 12:03 [entrez] AID - 10.1177/20473087261443264 [doi] PST - ppublish SO - Int J Nurs Knowl. 2026 Jul;37(3):311-320. doi: 10.1177/20473087261443264. Epub 2026 Apr 21. PMID- 42012383 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1558-9110 (Electronic) IS - 1058-0360 (Print) IS - 1058-0360 (Linking) VI - 35 IP - 4 DP - 2026 Jul 8 TI - How Do Infants Eat at Home? A Preliminary Study of Complementary Feeding Skills in the Naturalistic Environment. PG - 1451-1464 LID - 10.1044/2026_AJSLP-25-00409 [doi] AB - PURPOSE: Understanding feeding development is essential for improving the targeted management of pediatric feeding disorder (PFD), but information is scarce on how infants develop complementary feeding skills in their natural environments. This cross-sectional observational study was a first step toward (a) assessing the feasibility of characterizing infant feeding experiences in the home environment and (b) determining the concurrent predictors of infant complementary feeding skills using a dynamic systems approach. METHOD: Thirty-six 6- to 8-month-old infants and their caregivers participated; this sample was loaded with 11 infants considered "at risk" of developing feeding disorders due to experience in the neonatal intensive care unit. Feeding was assessed with the Oral Feeding Skills Scale (OFS-S) and an eating efficiency measure, extracted from caregiver-recorded videos of typical meals at home. Caregivers completed surveys and interviews to qualitatively characterize the infants' typical home feeding environment and infant experiences. Developmental covariates were assessed via standardized tests, and analyses included hierarchical logistic regressions. RESULTS: All enrolled families completed all components of data collection, and data analysis was found to be valid and reliable using caregiver-recorded methods in the home setting. Infants demonstrated a wide range of feeding experiences and variable complementary feeding skills (OFS-S scores of 15.67-52.67), with significant differences between risk groups (t = 4.39, p < .001); infants in the at-risk group demonstrated less skills and more variability. Risk group (p < .00015) and weeks of feeding experience (p < .0026) were the best concurrent predictors of infant oral-motor complementary feeding skills at 6-8 months of age. CONCLUSIONS: This study provides new evidence that it is feasible to observe infant complementary feeding skills in the home environment, and infants at risk for feeding disorders demonstrate complementary feeding skills different from those of low-risk peers. Future studies should include more infants in a longitudinal design to tease out influences on development, with the aim of early identification and treatment of PFD. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.32034999. FAU - Arkenberg, Rachel Hahn AU - Arkenberg RH AUID- ORCID: 0000-0002-9406-2004 AD - Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN. AD - Department of Speech, Language, and Hearing Sciences, Butler University, Indianapolis, IN. FAU - Delaney, Amy AU - Delaney A AUID- ORCID: 0000-0003-4731-9038 AD - Department of Speech Pathology and Audiology, Marquette University, Milwaukee, WI. FAU - Seidl, Amanda AU - Seidl A AD - Department of Communication Sciences & Disorders, University of Delaware, Newark. FAU - Moding, Kameron AU - Moding K AD - Department of Human Development and Family Science, Purdue University, West Lafayette, IN. FAU - Hustad, Katherine AU - Hustad K AUID- ORCID: 0000-0002-8544-7754 AD - Department of Communication Sciences and Disorders, University of Wisconsin-Madison. FAU - Craig, Bruce AU - Craig B AD - Department of Statistics, Purdue University, West Lafayette, IN. FAU - Malandraki, Georgia A AU - Malandraki GA AUID- ORCID: 0000-0002-7599-7728 AD - Department of Speech, Language, and Hearing Sciences, Purdue University, West Lafayette, IN. AD - Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN. LA - eng PT - Journal Article PT - Observational Study DEP - 20260421 PL - United States TA - Am J Speech Lang Pathol JT - American journal of speech-language pathology JID - 9114726 SB - IM MH - Humans MH - Infant MH - Female MH - Male MH - Cross-Sectional Studies MH - *Feeding Behavior MH - *Infant Nutritional Physiological Phenomena MH - Preliminary Data MH - *Infant Behavior MH - *Child Development MH - Caregivers MH - Feasibility Studies MH - Sucking Behavior MH - *Feeding and Eating Disorders of Childhood/diagnosis/physiopathology/psychology PMC - PMC13361701 EDAT- 2026/04/21 18:34 MHDA- 2026/07/08 18:51 PMCR- 2026/04/21 CRDT- 2026/04/21 10:14 PHST- 2026/07/08 18:51 [medline] PHST- 2026/04/21 18:34 [pubmed] PHST- 2026/04/21 10:14 [entrez] PHST- 2026/04/21 00:00 [pmc-release] AID - 23814764000300140072 [pii] AID - 10.1044/2026_AJSLP-25-00409 [doi] PST - ppublish SO - Am J Speech Lang Pathol. 2026 Jul 8;35(4):1451-1464. doi: 10.1044/2026_AJSLP-25-00409. Epub 2026 Apr 21. PMID- 42012091 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 1475-097X (Electronic) IS - 1475-0961 (Linking) VI - 46 IP - 3 DP - 2026 May TI - Lung function and exercise capacity in single ventricle patients post Fontan palliation and potential role of diaphragm ultrasound imaging. PG - e70063 LID - 10.1111/cpf.70063 [doi] AB - AIMS: Patients with Fontan circulation have reduced functional capacity, due to a reduced cardiac output, but also to an abnormal lung function and respiratory muscle weakness. This study aimed to assess lung function and exercise capacity in a cohort of patients with Fontan circulation and evaluate the prognostic impact of restrictive lung function (RLF). In addition, diaphragmatic ultrasound (DUS) investigated diaphragmatic function in a subgroup of patients. METHODS: Patients with Fontan palliation who underwent lung function evaluation were included. A subgroup of patients additionally underwent DUS to assess diaphragmatic function. RESULTS: The study population consisted of 53 post-Fontan patients (mean age 25 +/- 10 years). Exercise capacity was reduced, with a median peak VO(2) of 18.4 mL/kg/min (IQR 14.7-22.6). Oxygen pulse was reduced and flattened, and ventilatory efficiency was impaired (mean VE/VCO(2) slope 36 +/- 7), without evidence of mechanical ventilatory limitation. Spirometry revealed RLF in 48% of patients. RLF was associated with lower peripheral oxygen saturation, diuretic therapy use, and lower engagement in regular physical activity. Moreover, RLF was significantly associated with adverse events at follow-up (chi(2): 6.8, p = 0.004). Diaphragm ultrasound (DUS), performed in 10 patients, showed abnormal function of at least one hemidiaphragm in most cases. CONCLUSIONS: Patients with Fontan circulation exhibit a markedly reduced exercise functional capacity resulting from a complex interplay between cardiac, pulmonary, and peripheral factors. Restrictive lung function was associated with increased need for diuretic therapy and lower levels of physical activity. Abnormal diaphragmatic function was frequently observed and may represent a potentially modifiable contributor to functional limitation warranting further investigation. CI - (c) 2026 Scandinavian Society of Clinical Physiology and Nuclear Medicine. FAU - Festa Cilveti, Paula AU - Festa Cilveti P AD - School of Medicine, University of Pisa, Pisa, Italy. FAU - Marrone, Chiara AU - Marrone C AD - Pediatric Cardiology and Adult Congenital Heart Disease, Gabriele Monasterio Foundation, Massa, Italy. FAU - Ait-Ali, Lamia AU - Ait-Ali L AUID- ORCID: 0000-0003-1672-5308 AD - Pediatric Cardiology and Adult Congenital Heart Disease, Gabriele Monasterio Foundation, Massa, Italy. AD - Institute of Clinical Physiology, National Research Council of Italy, CNR Massa, Italy. FAU - Bastiani, Luca AU - Bastiani L AD - Institute of Clinical Physiology, National Research Council of Italy, CNR Massa, Italy. FAU - Simonini, Ludovica AU - Simonini L AD - Institute of Clinical Physiology, National Research Council of Italy, CNR Massa, Italy. FAU - Passino, Claudio AU - Passino C AD - Clinical Research Unit, Gabriele Monasterio Foundation, Pisa, Italy. FAU - Mannucci, Francesca AU - Mannucci F AD - Pneumologia Territoriale Valli Etrusche, Azienda Toscana Nord Ovest, Pisa, Italy. AD - Respiratory Department, Gabriele Monasterio Foundation, Pisa, Italy. FAU - Celi, Alessandro AU - Celi A AD - Department of Surgery, Medicine, Molecular Biology and Critical Care, University of Pisa, Pisa, Italy. FAU - Festa, Pierluigi AU - Festa P AD - Pediatric Cardiology and Adult Congenital Heart Disease, Gabriele Monasterio Foundation, Massa, Italy. FAU - Catapano, Giosue AU - Catapano G AD - Respiratory Department, Gabriele Monasterio Foundation, Pisa, Italy. LA - eng PT - Journal Article PL - England TA - Clin Physiol Funct Imaging JT - Clinical physiology and functional imaging JID - 101137604 SB - IM MH - Humans MH - *Fontan Procedure/adverse effects MH - Male MH - Female MH - Ultrasonography MH - *Diaphragm/diagnostic imaging/physiopathology MH - Adult MH - *Exercise Tolerance MH - *Lung/physiopathology/diagnostic imaging MH - Treatment Outcome MH - Young Adult MH - Predictive Value of Tests MH - Adolescent MH - *Heart Defects, Congenital/surgery/physiopathology/diagnostic imaging MH - Time Factors MH - *Univentricular Heart/surgery/physiopathology/diagnostic imaging MH - Recovery of Function MH - Exercise Test MH - Palliative Care OTO - NOTNLM OT - Fontan circulation OT - diaphragmatic ultrasound OT - lung function OT - restrictive lung function EDAT- 2026/04/21 13:11 MHDA- 2026/04/22 00:36 CRDT- 2026/04/21 08:43 PHST- 2026/02/27 00:00 [revised] PHST- 2025/10/16 00:00 [received] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/04/22 00:36 [medline] PHST- 2026/04/21 13:11 [pubmed] PHST- 2026/04/21 08:43 [entrez] AID - 10.1111/cpf.70063 [doi] PST - ppublish SO - Clin Physiol Funct Imaging. 2026 May;46(3):e70063. doi: 10.1111/cpf.70063. PMID- 42011820 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260819 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) VI - 4 IP - 4 DP - 2026 Apr 21 TI - Psychosocial interventions for supporting women to stop smoking in pregnancy. PG - CD001055 LID - 10.1002/14651858.CD001055.pub6 [doi] LID - CD001055 AB - RATIONALE: Tobacco smoking is a leading preventable cause of pregnancy complications with serious long-term impacts on women and babies. This update is needed to incorporate new evidence and ensure that guidance on psychosocial interventions in pregnancy remains current for policy and practice. OBJECTIVES: To assess the effects of psychosocial interventions provided to support pregnant women who are currently smoking or have recently quit, on smoking abstinence, continued postpartum abstinence, and infant outcomes. SEARCH METHODS: We searched Embase, MEDLINE, PsycINFO, four other databases and two trial registers, together with reference checking, citation searching, and contact with study authors to identify studies that are included in the review. The latest search date was November 2025. ELIGIBILITY CRITERIA: We included randomized controlled trials, cluster-randomized trials, and quasi-randomized controlled trials in pregnant women who smoked cigarettes or have recently quit, comparing psychosocial interventions (counseling, health education, feedback, social support, incentives, exercise) with usual care, less intensive interventions, or alternative interventions. We excluded studies on other forms of tobacco (e-cigarettes, smokeless tobacco), environmental tobacco smoke exposure, and those aimed outside of pregnancy (e.g. postpartum interventions). OUTCOMES: The critical outcome was self-reported and/or biochemically validated smoking abstinence in late pregnancy. The important outcomes included: smoking abstinence from zero to five months postpartum; mean birthweight; low birthweight (< 2500 g); preterm births (< 37 weeks); stillbirths; and neonatal intensive care unit (NICU) admissions. RISK OF BIAS: We used the Cochrane Risk of Bias tool 1. SYNTHESIS METHODS: We synthesized results for each outcome using random-effects meta-analysis where possible. Where this was not possible, we have presented narrative summaries. We used GRADE to assess the certainty of evidence for main outcomes, including smoking abstinence in late pregnancy, low birthweight, preterm birth, mean birthweight, stillbirth, and NICU admissions. INCLUDED STUDIES: We included 127 studies (including 145 study arms) with 47,361 participants. SYNTHESIS OF RESULTS: Smoking abstinence during late pregnancy All psychosocial interventions, compared with all comparator types, probably result in an important increase in the likelihood of smoking abstinence during late pregnancy (RR 1.41, 95% CI 1.30 to 1.54; I(2) = 47%; 117 studies, 33,694 participants; moderate-certainty evidence) and in the early postpartum period (0 to five months) (RR 1.33, 95% CI 1.18 to 1.50; I(2) = 28%; 42 studies, 11,977 participants; moderate-certainty evidence). Similar effects were observed for counseling compared to usual care (RR 1.51, 95% CI 1.26 to 1.82; I(2) = 51%; 32 studies, 12,920 participants; moderate-certainty evidence) and financial incentives compared to alternative interventions (RR 2.03, 95% CI 1.38 to 2.98; I(2) = 58%; 7 studies, 1837 participants; moderate-certainty evidence). Health education compared with usual care may result in an important increase in the likelihood of smoking abstinence during late pregnancy (RR 1.62, 95% CI 1.22 to 2.14; I(2) = 0%; 10 studies, 2137 participants; low-certainty evidence). Similar effects were observed for feedback compared to usual care (RR 2.17, 95% CI 0.79 to 5.92; I(2) = 54%; 4 studies, 442 participants; low-certainty evidence) and social support compared to less intensive interventions (RR 1.21, 95% CI 0.93 to 1.58; I(2) = 0%; 7 studies, 781 participants; low-certainty evidence). Exercise compared to usual care probably results in little to no difference in the likelihood of smoking abstinence during late pregnancy (RR 1.20, 95% CI 0.72 to 2.01; 1 study, 785 participants; moderate-certainty evidence) and the evidence was very uncertain about the effect of active compared to passive dissemination of a smoking cessation on the likelihood of smoking abstinence during late pregnancy (RR 1.63, 95% CI 0.62 to 4.32; 1 study, 194 participants; very low-certainty evidence). Infant outcomes All psychosocial interventions, compared with all comparator types, may result in an important increase in the mean birthweight of infants (MD 56.90, 95% CI 35.30 to 78.51; I(2) = 22%; 31 studies, 13,726 participants; low-certainty evidence) and an important decrease in the likelihood of infants born with low birthweight (< 2500 g) (RR 0.82, 95% CI 0.73 to 0.94; I(2) = 0%; 20 studies, 10,190 participants; low-certainty evidence). The evidence was very uncertain about the effect of psychosocial interventions compared with all comparators on the likelihood of preterm births (RR 0.96, 95% CI 0.82 to 1.13; I(2) = 21%; 23 studies, 11,580 participants; very low-certainty evidence). There is probably little to no difference between psychosocial interventions and all comparators in the likelihood of stillbirth (RR 1.11, 95% CI 0.72 to 1.73; I(2) = 0%; 10 studies, 7481 participants; moderate-certainty evidence). All psychosocial interventions, compared with all comparators, may result in an important decrease in the likelihood of infants being admitted to the NICU immediately after birth (RR 0.84, 95% CI 0.70 to 1.01; I(2) = 0%; 12 studies, 3584 participants; low-certainty evidence). Health equity Half of the studies included women from disadvantaged backgrounds, including 11 studies involving ethnic minorities and four involving indigenous communities. Few studies examined whether intervention effects differed across population groups, leaving insufficient evidence to determine how interventions might be tailored to improve effectiveness in priority populations. Certainty of evidence Our confidence in the evidence is limited due to study limitations and imprecision. Several studies were unclear regarding random sequence generation and allocation concealment. For some outcomes, the 95% confidence intervals crossed our thresholds for important effects, leading to downgrading for imprecision. AUTHORS' CONCLUSIONS: Counseling and financial incentives probably support women to stop smoking, while health education, feedback, and social support may support women to stop smoking in late pregnancy, by an amount likely to be important. Psychosocial interventions may also reduce the proportion of infants born with low birthweight, increase mean birthweight, and reduce the number of infants admitted to NICU. These findings were not evident in ethnic minority or Indigenous populations. FUNDING: This Cochrane review was funded (partly) by the 2021 MRFF Maternal Health and Healthy Lifestyles (2022138), NHMRC Leadership Fellowship (GNT2025437), and NHMRC Investigator Grant (GNT2009612). REGISTRATION: Protocol (1998) https://doi.org/10.1002/14651858.CD001055 Original review (1999) DOI: 10.1002/14651858.CD001055 (this first version of the review is not available in the Cochrane Library) Review update (2004) https://doi.org/10.1002/14651858.CD001055.pub2 Review update (2009) https://doi.org/10.1002/14651858.CD001055.pub3 Review update (2013) https://doi.org/10.1002/14651858.CD001055.pub4 Review update (2017) https://doi.org/10.1002/14651858.CD001055.pub5. CI - Copyright (c) 2026 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. FAU - Freijah, Isabella AU - Freijah I AD - Indigenous Health Equity Unit, Onemda, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia. FAU - Jones, Kimberley A AU - Jones KA AD - Indigenous Health Equity Unit, Onemda, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia. FAU - Coleman, Tim AU - Coleman T AD - Centre for Academic Primary Care, Lifespan and Population Health, School of Medicine, University of Nottingham, Nottingham, UK. FAU - Perlen, Susan M AU - Perlen SM AD - Centre for Quality and Patient Safety Research (QPS) in the Institute for Health Transformation, School of Nursing and Midwifery, Faculty of Health, Deakin University, Geelong, Australia. FAU - Kennedy, Michelle AU - Kennedy M AD - College of Health Medicine and Wellbeing, University of Newcastle, Callaghan, Australia. FAU - Passey, Megan E AU - Passey ME AD - The Daffodil Centre, The University of Sydney, Lismore, Australia. FAU - McKenzie, Joanne E AU - McKenzie JE AD - Methods in Evidence Synthesis Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia. FAU - Chamberlain, Catherine AU - Chamberlain C AUID- ORCID: 0000-0003-3446-0227 AD - Indigenous Health Equity Unit, Onemda, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260421 PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 SB - IM UOF - Cochrane Database Syst Rev. 2017 Feb 14;2:CD001055. doi: 10.1002/14651858.CD001055.pub5. PMID: 28196405 MH - Humans MH - Female MH - Pregnancy MH - *Smoking Cessation/methods/psychology MH - Randomized Controlled Trials as Topic MH - *Psychosocial Intervention/methods MH - Infant, Newborn MH - Social Support MH - Infant, Low Birth Weight MH - *Pregnancy Complications/prevention & control MH - Smoking Prevention MH - Premature Birth/epidemiology MH - Smoking/therapy MH - Counseling PMC - PMC13097252 COIS- Isabella Freijah: The author declares no competing interests. Kimberly A Jones: The author declares no competing interests. Tim Coleman has received awards from NIHR, HTA, and NIHR paid to his institution. These awards have been used to run research projects. He is an NIHR Senior Investigator. Tim Coleman is also an author and contact person for the Cochrane Review entitled 'Pharmacological Interventions to promote smoking cessation in pregnancy' [54]. Susan M Perlen: The author declares no competing interests. Michelle Kennedy: The author declares no competing interests. Megan Passey: The author declares no competing interests. Joanne E McKenzie: The author declares no competing interests. Catherine Chamberlain is receiving an Australian National Health and Medical Research Council Leadership Fellowship (GNT2025437). Catherine Chamberlain is also an author on the Cochrane Review entitled 'Pharmacological Interventions to promote smoking cessation in pregnancy" [54]. EDAT- 2026/04/21 13:11 MHDA- 2026/04/22 00:33 PMCR- 2027/04/21 CRDT- 2026/04/21 06:33 PHST- 2026/04/22 00:33 [medline] PHST- 2026/04/21 13:11 [pubmed] PHST- 2026/04/21 06:33 [entrez] PHST- 2027/04/21 00:00 [pmc-release] AID - CD001055.pub6 [pii] AID - 10.1002/14651858.CD001055.pub6 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2026 Apr 21;4(4):CD001055. doi: 10.1002/14651858.CD001055.pub6. PMID- 42011405 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260421 LR - 20260813 IS - 2667-3681 (Electronic) IS - 2667-3681 (Linking) VI - 18 DP - 2026 Jun TI - Obesity care education in Canadian medical schools: A multi-site qualitative study. PG - 100259 LID - 10.1016/j.obpill.2026.100259 [doi] LID - 100259 AB - BACKGROUND: Many medical professionals and trainees do not feel comfortable providing care for obesity. Therefore, there is a need to improve the standards of obesity education and medical curriculum in Canada. Our study aims to determine how obesity care is currently taught and to identify the perceived most effective teaching methods for improving obesity care education in Canadian medical schools. METHODS: Our study employs a cross-sectional design and is guided by constructivist grounded theory, which posits that the interpretation of study results is shaped by the researcher. Attempts to recruit participants were made at 8 of 14 English-speaking medical schools across Canada. A total of n = 17 participants from 4 of these schools are represented in our study. Focus groups with third- and fourth-year Canadian medical students were conducted to identify strategies to improve the delivery of obesity care education. Focus group questions were developed by a medical professional and researcher, and face validity was conferred. Transcripts were anonymized using MacWhisper (Version 12.17), verified for accuracy, and analyzed thematically and content-analytically using Atlas.ti (V.25). RESULTS: Focus group data yielded four main themes-Theme 1: Preceptors lack the knowledge and skills to teach students effective obesity care, which can perpetuate the idea that engagement in obesity care/management is undervalued and contributes to ongoing stigma and health inequities faced by people living with obesity. Theme 2: The medical curriculum and assessment do not emphasize deliberate curricula in obesity care, integrated obesity care across curricula and conditions, given its impact on comorbidities. Theme 3: Students are generally not comfortable with pediatric obesity care because it is not taught. Theme 4: Obesity curricula employ multi-component teaching methods. CONCLUSION: Our study identifies methods to improve obesity care education across Canadian medical schools. While multiple methods of curriculum delivery are effective, ensuring that instructors are proficient and stigma-free in delivering obesity-related topics is essential. CI - (c) 2026 The Authors. FAU - Delaney, Kerri Z AU - Delaney KZ AD - The Dr. Gilles Arcand Centre for Health Equity, Sudbury & Thunder Bay, ON, Canada. AD - The Northern Ontario School of Medicine University, Sudbury & Thunder Bay, ON, Canada. AD - Department of Family Medicine, Dalhousie University, Halifax, NS, Canada. FAU - Shrestha, Lucy AU - Shrestha L AD - The Dr. Gilles Arcand Centre for Health Equity, Sudbury & Thunder Bay, ON, Canada. AD - The Northern Ontario School of Medicine University, Sudbury & Thunder Bay, ON, Canada. FAU - Nagpal, Taniya S AU - Nagpal TS AD - Faculty of Kinesiology, Sport, and Recreation, University of Alberta, AB, Canada. FAU - Geddie, Hannah AU - Geddie H AD - Department of Pediatrics, McMaster University, Hamilton, ON, Canada. FAU - Tenedero, Christine AU - Tenedero C AD - Department of Pediatrics, McMaster University, Hamilton, ON, Canada. FAU - Wicklum, Sonja AU - Wicklum S AD - Department of Family Medicine, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. FAU - Piccinini-Vallis, Helena AU - Piccinini-Vallis H AD - Department of Family Medicine, Dalhousie University, Halifax, NS, Canada. FAU - Pearce, Nicole AU - Pearce N AD - Obesity Canada, Edmonton, Alberta, Canada. FAU - McMillan, Michelle AU - McMillan M AD - Obesity Canada, Edmonton, Alberta, Canada. FAU - Zevin, Boris AU - Zevin B AD - Department of Surgery at Queen's University, Kingston, ON, Canada. FAU - Vallis, Michael AU - Vallis M AD - Department of Family Medicine, Dalhousie University, Halifax, NS, Canada. FAU - Sockalingam, Sanjeev AU - Sockalingam S AD - Obesity Canada, Edmonton, Alberta, Canada. AD - Centre for Addiction and Mental Health, Toronto, ON, Canada. AD - Department of Psychiatry, University of Toronto, Toronto, ON, Canada. FAU - Cameron, Erin AU - Cameron E AD - The Dr. Gilles Arcand Centre for Health Equity, Sudbury & Thunder Bay, ON, Canada. AD - The Northern Ontario School of Medicine University, Sudbury & Thunder Bay, ON, Canada. FAU - Abraham, Roshan AU - Abraham R AD - Department of Family Medicine, Faculty of Medicine and Dentistry, College of Health Sciences, University of Alberta, Edmonton, Alberta, Canada. LA - eng PT - Journal Article DEP - 20260318 PL - United States TA - Obes Pillars JT - Obesity pillars JID - 9918697364706676 PMC - PMC13091836 COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/21 13:11 MHDA- 2026/04/21 13:12 PMCR- 2026/03/18 CRDT- 2026/04/21 03:59 PHST- 2026/02/10 00:00 [received] PHST- 2026/03/13 00:00 [revised] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/04/21 13:12 [medline] PHST- 2026/04/21 13:11 [pubmed] PHST- 2026/04/21 03:59 [entrez] PHST- 2026/03/18 00:00 [pmc-release] AID - S2667-3681(26)00015-X [pii] AID - 100259 [pii] AID - 10.1016/j.obpill.2026.100259 [doi] PST - epublish SO - Obes Pillars. 2026 Mar 18;18:100259. doi: 10.1016/j.obpill.2026.100259. eCollection 2026 Jun. PMID- 42011197 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260421 LR - 20260813 IS - 2768-2765 (Electronic) IS - 2768-2765 (Linking) VI - 15 DP - 2026 May TI - What's New in Osteogenesis Imperfecta. PG - 100373 LID - 10.1016/j.jposna.2026.100373 [doi] LID - 100373 AB - Osteogenesis imperfecta (OI) is a diverse group of genetic disorders mainly caused by pathogenic variants in COL1A1 and COL1A2 that interfere with type I collagen production, resulting in bone fragility and multisystem issues. Since 2019, the understanding and treatment of OI have improved considerably. Advances in molecular genetics have broadened the OI classification to 22 types, with new variants affecting pathways beyond collagen synthesis, including osteoblast differentiation and bone mineralization. Bisphosphonates continue to be the primary pharmacologic treatment, effectively reducing fracture risk, and increasing bone mineral density, although recent studies highlight delayed osteotomy healing and some differences among specific agents. Newer therapies-including denosumab, antisclerostin antibodies such as setrusumab, and mesenchymal stem cell transplantation-show promise but need further validation through randomized trials. Overall, nonoperative care, including good nutrition, vitamin D supplementation, personalized physical therapy, and orthotic support, remains essential for improving function and preventing fractures. Intramedullary stabilization with telescoping rods has become the standard for both fracture fixation and deformity correction, providing better long-term outcomes and lower reoperation rates compared to static rods. Advances in surgical planning highlight the importance of precise rod alignment, avoiding cortical stress shielding, and protecting the periosteum to promote healing. Spinal deformities, including scoliosis and basilar invagination, are increasingly managed through multidisciplinary monitoring, bisphosphonate therapy, and refined surgical strategies that prioritize stability over maximum correction. Optimal outcomes in OI require coordinated multidisciplinary care involving orthopaedic surgeons, medical colleagues, physical therapists, and other specialists. Ongoing research continues to refine medical and surgical methods to improve function, quality of life, and long-term skeletal health for children with OI. KEY CONCEPTS: (1)Multidisciplinary care is vital in caring for children with OI.(2)Medical optimization through nutrition, medications like bisphosphonates, vitamin D supplementation, and physical therapy is important for both preoperative and postoperative children with OI.(3)Intramedullary stabilization with telescoping or nontelescoping nails to protect the entire length of the bone is the mainstay of surgical treatment. CI - (c) 2026 The Authors. FAU - Wallace, Maegen AU - Wallace M AD - Phoenix Children's Hospital, Phoenix, AZ, USA. FAU - Menapace, Bryan AU - Menapace B AD - Shriners Children's Portland, Portland, OR, USA. FAU - Herrero, Christina AU - Herrero C AD - RWJBarnabas Health, New Brunswick, NJ, USA. FAU - Franzone, Jeanne M AU - Franzone JM AD - Nemours Children's Hospital Delaware, Wilmington, DE, USA. LA - eng PT - Journal Article PT - Review DEP - 20260321 PL - United States TA - J Pediatr Soc North Am JT - Journal of the Pediatric Orthopaedic Society of North America JID - 101776896 PMC - PMC13092026 OTO - NOTNLM OT - Bisphosphonates OT - Osteogenesis imperfecta OT - Scoliosis OT - Telescoping rods COIS- The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Maegen Wallace reports a relationship with OrthoPediatrics Corp that includes: consulting or advisory. Maegen Wallace reports a relationship with Amgen Inc that includes: nonfinancial support. Maegen Wallace reports a relationship with Ultragenyx Pharmaceutical Inc that includes: nonfinancial support. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. There was no funding for this project. EDAT- 2026/04/21 13:11 MHDA- 2026/04/21 13:12 PMCR- 2026/03/21 CRDT- 2026/04/21 03:55 PHST- 2026/03/12 00:00 [received] PHST- 2026/03/16 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/04/21 13:12 [medline] PHST- 2026/04/21 13:11 [pubmed] PHST- 2026/04/21 03:55 [entrez] PHST- 2026/03/21 00:00 [pmc-release] AID - S2768-2765(26)00052-0 [pii] AID - 100373 [pii] AID - 10.1016/j.jposna.2026.100373 [doi] PST - epublish SO - J Pediatr Soc North Am. 2026 Mar 21;15:100373. doi: 10.1016/j.jposna.2026.100373. eCollection 2026 May. PMID- 42010697 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 27 IP - 1 DP - 2026 Apr 20 TI - EMERGE Mothers and Kids: a longitudinal cohort study of mothers and children enrolled in the randomized placebo-controlled trial of metformin in women with GDM (EMERGE): study protocol. LID - 10.1186/s13063-026-09703-6 [doi] LID - 405 AB - BACKGROUND: Pregnancies complicated by gestational diabetes mellitus (GDM) are associated with increased risks of adverse perinatal outcomes and with long-term metabolic and cardiovascular consequences for both mother and child. The original EMERGE randomized controlled trial (RCT) evaluated the effectiveness of early metformin in addition to usual care in women with GDM on glycemic control and perinatal outcomes. The primary objective of the EMERGE Mothers and Kids study is to evaluate long-term maternal cardiometabolic health and child anthropometric and neurodevelopmental outcomes following participation in the EMERGE trial. METHODS: This is a prospective, observational longitudinal cohort follow-up study of women and their children previously enrolled in the EMERGE trial (NCT06327191). Participants are invited to attend a follow-up visit in a single-site hospital-based clinical research setting at the Clinical Research Facility Galway, Ireland. Key inclusion criteria are women and their children who participated in the EMERGE trial and consent to follow-up. Key exclusion criteria include participants who did not provide consent for future follow-up studies. The planned follow-up sample is a pragmatic convenience sample of up to 321 mother-child pairs. A single follow-up visit will be conducted up to 6 years after the index pregnancy. Maternal assessments include anthropometric data, glucose tolerance, and metabolic parameters. Child assessments include growth metrics, adiposity measured via skinfold thickness, and neurodevelopmental status assessed through validated questionnaires. Additional data on quality of life, mental health, breastfeeding, and health economics will also be collected. DISCUSSION: This study aims to provide insights into the long-term safety and efficacy of metformin use during pregnancy, addressing the evidence gap in maternal cardiometabolic outcomes after metformin-treated GDM while also assessing child anthropometric and neurodevelopmental outcomes. TRIAL REGISTRATION: ClinicalTrials.gov NCT06327191. Registered on November 21, 2023. First planned enrollment in this follow-up study: July 2024. Trial record available at https://clinicaltrials.gov/study/NCT06327191 . CI - (c) 2026. The Author(s). FAU - Scairati, Roberta AU - Scairati R AD - HRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland. AD - Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy. FAU - Newman, Christine AU - Newman C AD - HRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland. cnewman@universityofgalway.ie. AD - College of Medicine Nursing and Health Sciences, University of Galway, Galway City, Co Galway, Ireland. cnewman@universityofgalway.ie. AD - Galway University Hospital, Newcastle Road, Galway City, Co Galway, Ireland. cnewman@universityofgalway.ie. AD - Institute for Clinical Trials, University of Galway, Galway City, Co Galway, Ireland. cnewman@universityofgalway.ie. AD - Clinical Trial Network Diabetes, University of Galway, Galway City, Co Galway, Ireland. cnewman@universityofgalway.ie. FAU - Alvarez-Iglesias, Alberto AU - Alvarez-Iglesias A AD - HRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland. FAU - Smyth, Andrew AU - Smyth A AD - HRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland. AD - College of Medicine Nursing and Health Sciences, University of Galway, Galway City, Co Galway, Ireland. AD - Galway University Hospital, Newcastle Road, Galway City, Co Galway, Ireland. FAU - O'Shea, Paula M AU - O'Shea PM AD - College of Medicine Nursing and Health Sciences, University of Galway, Galway City, Co Galway, Ireland. FAU - Devane, Declan AU - Devane D AD - HRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland. AD - HRB Trials Methodology Research Network, University of Galway, Galway City, Co Galway, Ireland. FAU - Gillespie, Paddy AU - Gillespie P AD - School of Business and Economics, University of Galway, Galway City, Co Galway, Ireland. FAU - Egan, Aoife M AU - Egan AM AD - Mayo Clinic, Rochester, MN, USA. FAU - O'Donnell, Martin AU - O'Donnell M AD - HRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland. AD - College of Medicine Nursing and Health Sciences, University of Galway, Galway City, Co Galway, Ireland. AD - Galway University Hospital, Newcastle Road, Galway City, Co Galway, Ireland. AD - Institute for Clinical Trials, University of Galway, Galway City, Co Galway, Ireland. FAU - Dunne, Fidelma P AU - Dunne FP AD - HRB Clinical Research Facility Galway, University of Galway, Galway City, Co Galway, Ireland. AD - College of Medicine Nursing and Health Sciences, University of Galway, Galway City, Co Galway, Ireland. AD - Galway University Hospital, Newcastle Road, Galway City, Co Galway, Ireland. AD - Institute for Clinical Trials, University of Galway, Galway City, Co Galway, Ireland. AD - Clinical Trial Network Diabetes, University of Galway, Galway City, Co Galway, Ireland. LA - eng SI - ClinicalTrials.gov/NCT06327191 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260420 PL - England TA - Trials JT - Trials JID - 101263253 RN - 9100L32L2N (Metformin) RN - 0 (Hypoglycemic Agents) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Female MH - *Metformin/therapeutic use/adverse effects/administration & dosage MH - Pregnancy MH - *Diabetes, Gestational/drug therapy/blood/diagnosis MH - Longitudinal Studies MH - *Hypoglycemic Agents/therapeutic use/adverse effects/administration & dosage MH - Prospective Studies MH - Child Development MH - Randomized Controlled Trials as Topic MH - Adult MH - Child MH - Infant, Newborn MH - Blood Glucose/drug effects/metabolism MH - Observational Studies as Topic MH - Time Factors MH - Infant MH - Child, Preschool MH - Treatment Outcome PMC - PMC13224567 OTO - NOTNLM OT - Gestational diabetes mellitus OT - Long-term follow-up OT - Metformin OT - Pregnancy OT - Randomized controlled trial COIS- Declarations. Ethics approval and consent to participate: The study received ethical approval from the Galway Clinical Research Ethics Committee. Written informed consent was obtained at the time of original enrollment and reaffirmed at the follow-up visit (reference number CA 3024). Consent for publication: This manuscript does not contain any individual person's data in any form. Consent for publication is therefore not applicable. Results will be published in peer-reviewed journals and presented at international conferences. Competing interests: The authors declare no competing interests. The study received funding from Merck Healthcare KGaA, Darmstadt, Germany, which had no involvement in the design, analysis, or reporting of the study. EDAT- 2026/04/21 13:11 MHDA- 2026/06/01 00:32 PMCR- 2026/04/20 CRDT- 2026/04/21 00:19 PHST- 2025/09/23 00:00 [received] PHST- 2026/04/03 00:00 [accepted] PHST- 2026/06/01 00:32 [medline] PHST- 2026/04/21 13:11 [pubmed] PHST- 2026/04/21 00:19 [entrez] PHST- 2026/04/20 00:00 [pmc-release] AID - 10.1186/s13063-026-09703-6 [pii] AID - 9703 [pii] AID - 10.1186/s13063-026-09703-6 [doi] PST - epublish SO - Trials. 2026 Apr 20;27(1):405. doi: 10.1186/s13063-026-09703-6. PMID- 42010512 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Apr 20 TI - AI-powered population-based birth cohort study in the Western Province of Sri Lanka: study protocol. LID - 10.1186/s12884-026-09098-x [doi] LID - 616 AB - BACKGROUND: Despite Sri Lanka's long-standing success in reducing maternal and neonatal mortality, progress has stagnated in recent decades. Conventional surveillance systems lack granular, real-time data to predict and prevent adverse outcomes. Artificial Intelligence (AI) has transformative potential to improve risk prediction, early detection, and proactive management of maternal and neonatal complications. METHODS: This prospective birth cohort study will recruit 2,000 pregnant women in different stages of gestation across all 54 divisional health areas (DHA) in the Western Province, Sri Lanka. Data will be collected using an Electronic Health Record (EHR) System named 'Maathru', together with a companion mobile application designed for pregnant women. Data collection will span from the antenatal period through six weeks postpartum. The mobile app captures patient reported data such as information on contraction frequency, general health status, danger signs, heavy physical activity, exposure to violence, sexual activity, and substance use directly from the pregnant mothers. The data gathered from the EHR will be used in the training of AI algorithms to predict key maternal and neonatal outcomes, including postpartum haemorrhage, preeclampsia, intrauterine growth restriction, need for labour induction, gestational diabetes mellitus, caesarean section, postpartum depression, preterm birth, low birth weight, Neonatal Intensive Care Unit (NICU) admission, and feeding difficulties. An iterative process will be adopted in training the algorithm. The AI models were selected based on prior literature and evidence from related studies. The design of the EHR will facilitate integration of the trained AI models, which will then contribute to clinical decision making process supporting the field staff and alerting system for health professionals within the Maathru system and the mobile app respectively. DISCUSSION: The study seeks to demonstrate feasibility and validity of AI-powered predictive analytics within routine field-based maternal and child health (MCH) workflows. The mobile application enhance the communication, and monitor maternal well-being. It aims to create a scalable platform for national-level implementation, generate disaggregated data for maternal and neonatal health, and strengthen evidence-based decision making to achieve Sustainable Development Goals (SDGs) related to maternal and neonatal mortality reduction. TRIAL REGISTRATION: Not applicable (observational study). FAU - Jayaratne, Kapila AU - Jayaratne K AD - Department of Community Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. FAU - Hettiarachchi, Dineshani AU - Hettiarachchi D AD - Department of Anatomy, Genetics and Biomedical Informatics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. dineshani@anat.cmb.ac.lk. FAU - Rajapaksha, Rasika AU - Rajapaksha R AD - Faculty of Computing and Technology, University of Kelaniya, Kelaniya, Sri Lanka. FAU - Siribaddana, Pandula AU - Siribaddana P AD - Postgraduate Institute of Medicine, University of Colombo, Colombo, Sri Lanka. FAU - Rishard, Mohamed AU - Rishard M AD - Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. FAU - Pushpakumara, Chamli AU - Pushpakumara C AD - Faculty of Computing and Technology, University of Kelaniya, Kelaniya, Sri Lanka. FAU - Chathurangana, Prasad AU - Chathurangana P AD - Department of Paediatrics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. FAU - Dissanayake, Vajira H W AU - Dissanayake VHW AD - Department of Anatomy, Genetics and Biomedical Informatics, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. LA - eng PT - Journal Article DEP - 20260420 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Sri Lanka/epidemiology MH - Pregnancy MH - Prospective Studies MH - Electronic Health Records MH - *Artificial Intelligence MH - Infant, Newborn MH - *Pregnancy Complications/diagnosis/epidemiology MH - Mobile Applications MH - Pregnancy Outcome MH - Research Design PMC - PMC13237931 OTO - NOTNLM OT - AI-powered predictive mobile app OT - Adverse pregnancy outcomes OT - Artificial Intelligence in Maternal Health OT - Birth cohort study OT - Electronic Health Records OT - Machine learning OT - Predictive Modeling in Obstetrics OT - Sri Lanka COIS- Declarations. Ethics approval and consent to participate: Granted by the Ethics Review Committee, Health Informatics Society of Sri Lanka (HISSL). Ethical approval for this study was obtained from the Ethics Review Committee of the Health Informatics Society of Sri Lanka (HISSL), under reference number 2024-001 (approved on 27 February 2025). The study is conducted in accordance with relevant guidelines and regulations, including the Declaration of Helsinki. Written informed consent will be obtained from all participants prior to enrolment in the study. Participant confidentiality and data privacy will be strictly maintained throughout the study using anonymization, secure data storage, and restricted access protocols. Competing interests: The authors declare no competing interests. EDAT- 2026/04/21 13:11 MHDA- 2026/06/28 04:09 PMCR- 2026/04/20 CRDT- 2026/04/21 00:06 PHST- 2026/03/02 00:00 [received] PHST- 2026/04/09 00:00 [accepted] PHST- 2026/06/28 04:09 [medline] PHST- 2026/04/21 13:11 [pubmed] PHST- 2026/04/21 00:06 [entrez] PHST- 2026/04/20 00:00 [pmc-release] AID - 10.1186/s12884-026-09098-x [pii] AID - 9098 [pii] AID - 10.1186/s12884-026-09098-x [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Apr 20;26(1):616. doi: 10.1186/s12884-026-09098-x. PMID- 42010166 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20261010 IS - 1433-3023 (Electronic) IS - 0937-3462 (Linking) VI - 37 IP - 6 DP - 2026 Jun TI - Compartment-Specific Associations Between Perineal Body Length and Pelvic Organ Prolapse in Postpartum Women. PG - 1819-1829 LID - 10.1007/s00192-026-06563-1 [doi] AB - INTRODUCTION AND HYPOTHESIS: Pelvic floor dysfunction (PFD) is common after childbirth, but the role of perineal body dimensions in compartment-specific prolapse remains unclear. To investigate the association between perineal body length and various types of pelvic floor dysfunction in postpartum women, with emphasis on compartment-specific effects. METHODS: This cross-sectional study included 182 women assessed 30-90 days postpartum at a specialized pelvic floor clinic. Trained examiners measured perineal body length; outcomes assessed were anterior/posterior wall prolapse, uterine prolapse, stress urinary incontinence (SUI), and pelvic floor muscle weakness. Multivariable logistic regression (adjusted for age, pre-pregnancy BMI, delivery mode, postpartum days) was performed. Examiners were partially blinded. RESULTS: Perineal body length showed compartment-specific prolapse associations: longer length was inversely associated with posterior wall prolapse (OR 0.544, 95% CI 0.313-0.943, P = 0.030) but positively associated with anterior wall prolapse (OR 3.558, 95% CI 1.133-11.167, P = 0.030; exploratory due to a few non-cases and wide CIs). No significant associations were observed with SUI, muscle weakness, or uterine prolapse. Sensitivity analysis including 16 additional women assessed after 90 days (total n = 198) showed consistent results. CONCLUSIONS: Perineal body length is differentially associated with anterior and posterior prolapse, reflecting compartment-specific pelvic floor support. The cross-sectional design and lack of pre-delivery measurements mean findings are associative (not causal) and should be validated in larger prospective studies. CI - (c) 2026. The Author(s), under exclusive license to International Urogynecological Association. FAU - Liu, Yun AU - Liu Y AD - Department of Obstetrics and Gynecology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, GuangDong Province, China. AD - Pelvic Floor Disorders Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, GuangDong Province, China. FAU - He, Juan AU - He J AD - Department of Obstetrics and Gynecology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, GuangDong Province, China. AD - Pelvic Floor Disorders Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, GuangDong Province, China. FAU - Fei, Hui AU - Fei H AD - Department of Obstetrics and Gynecology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, GuangDong Province, China. AD - Pelvic Floor Disorders Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, GuangDong Province, China. FAU - Li, Tian AU - Li T AD - Department of Obstetrics and Gynecology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, GuangDong Province, China. litian@sysush.com. AD - Pelvic Floor Disorders Center, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, GuangDong Province, China. litian@sysush.com. LA - eng GR - JCYJ20250604143739051/Shenzhen Basic Research Special Fund Project for Natural Science Research/ PT - Journal Article DEP - 20260420 PL - England TA - Int Urogynecol J JT - International urogynecology journal JID - 101567041 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - *Perineum/anatomy & histology/pathology MH - Adult MH - *Pelvic Organ Prolapse/etiology/pathology MH - Postpartum Period MH - Pelvic Floor/physiopathology MH - Urinary Incontinence, Stress/etiology MH - Uterine Prolapse/etiology OTO - NOTNLM OT - Compartment-specific support OT - Pelvic floor dysfunction OT - Pelvic organ prolapse OT - Perineal body OT - Postpartum COIS- Declarations. Ethics Approval: This study was approved by the Ethics Committee of the Seventh Affiliated Hospital of Sun yet-san University. Conflicts of interest: None. EDAT- 2026/04/21 07:11 MHDA- 2026/06/27 00:50 CRDT- 2026/04/20 23:39 PHST- 2025/11/13 00:00 [received] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/06/27 00:50 [medline] PHST- 2026/04/21 07:11 [pubmed] PHST- 2026/04/20 23:39 [entrez] AID - 10.1007/s00192-026-06563-1 [pii] AID - 10.1007/s00192-026-06563-1 [doi] PST - ppublish SO - Int Urogynecol J. 2026 Jun;37(6):1819-1829. doi: 10.1007/s00192-026-06563-1. Epub 2026 Apr 20. PMID- 42009570 OWN - NLM STAT- Publisher LR - 20260420 IS - 1468-201X (Electronic) IS - 1355-6037 (Linking) DP - 2026 Apr 20 TI - Home-based, online-monitored high-intensity interval training improves fitness in patients with tetralogy of Fallot: a randomised controlled trial. LID - heartjnl-2025-327201 [pii] LID - 10.1136/heartjnl-2025-327201 [doi] AB - INTRODUCTION: Reduced exercise performance is common in patients with repaired tetralogy of Fallot (rToF) and relates to adverse outcomes. The effects of high-intensity interval training (HIIT) in rToF are unknown. Furthermore, it is unknown if home-based, online-monitored exercise training is effective in rToF. We aimed to examine the feasibility, safety and effects of home-based HIIT in patients with rToF. METHODS: Patients aged 12-30 years (n=34, median age 16 (IQR 14-23)) with rToF were randomised to a 12-week home-based HIIT programme or standard of care (SOC). HIIT was prescribed in three 30 min sessions/week, with heart rate telemonitoring. SOC included exercise as usual. Co-primary end points were mean differences in peak oxygen consumption (VO2) and maximal workload, analysed using linear mixed-effects (LME) models. Secondary end points were: echocardiography, ECG and MRI-derived measures of cardiac structure and function. RESULTS: No serious adverse events occurred. After HIIT, peak VO2 increased from 38.3 (34.0-42.5) mL/kg/min to 40.9 (36.6-45.2) mL/kg/min (∆ 4.0 mL/kg/min, compared with control period (95% CI 1.52 to 6.53)), workload increased from 204 (174-234) W to 218 (188-248) W (∆ 17 W, compared with control period (95% CI 5 to 30)). No changes in cardiac volumes and ejection fraction were observed after HIIT. VO2 improved after HIIT independent of baseline fitness, body mass index and biventricular size. Notably, lower right ventricular ejection fraction (RV EF) was associated with greater improvement. CONCLUSION: HIIT significantly enhances exercise capacity in adolescents and young adults with rToF without adverse effects on cardiac structure or function, although the sample size limits the detection of subtle changes and can be successfully performed at home with online monitoring. This intervention offers a feasible alternative to traditional, on-site supervised exercise programmes, for patients with rToF, including those with lower RV EF. TRIAL REGISTRATION NUMBER: NTR2731. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - van Genuchten, Wouter Jeroen AU - van Genuchten WJ AUID- ORCID: 0000-0002-7882-1162 AD - Department of Paediatrics, Division of Cardiology, Erasmus MC Sophia, Rotterdam, The Netherlands. FAU - Fejzic, Zina AU - Fejzic Z AD - Department of Pediatric Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands. FAU - Kauling, Robert M AU - Kauling RM AD - Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC, Rotterdam, The Netherlands. FAU - Koopman, Laurens AU - Koopman L AD - Department of Paediatrics, Division of Cardiology, Erasmus MC Sophia, Rotterdam, The Netherlands. FAU - van Deutekom, Arend W AU - van Deutekom AW AD - Department of Paediatrics, Division of Cardiology, Erasmus MC Sophia, Rotterdam, The Netherlands. FAU - van Dijk, Arie P AU - van Dijk AP AD - Department of Cardiology, Radboud University Medical Center, Nijmegen, The Netherlands. FAU - van den Berg, Linda Elisabeth AU - van den Berg LE AD - Department of Orthopaedics and Sports Medicine, Erasmus MC, Rotterdam, The Netherlands. FAU - Bartelds, Beatrijs AU - Bartelds B AD - Department of Paediatrics, Division of Cardiology, Erasmus MC Sophia, Rotterdam, The Netherlands. FAU - Boersma, Eric AU - Boersma E AUID- ORCID: 0000-0003-1159-7802 AD - Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC, Rotterdam, The Netherlands. FAU - Snoeren, Miranda AU - Snoeren M AD - Department of Medical Imaging, Radboud University Medical Center, Nijmegen, The Netherlands. FAU - Hirsch, Alexander AU - Hirsch A AUID- ORCID: 0000-0002-3315-2006 AD - Department of Cardiology, Thorax Center, Cardiovascular Institute, Erasmus MC, Rotterdam, The Netherlands. AD - Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands. FAU - Helbing, Willem A AU - Helbing WA AUID- ORCID: 0000-0002-1023-1537 AD - Department of Paediatrics, Division of Cardiology, Erasmus MC Sophia, Rotterdam, The Netherlands w.a.helbing@erasmusmc.nl. AD - Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands. LA - eng PT - Journal Article DEP - 20260420 PL - England TA - Heart JT - Heart (British Cardiac Society) JID - 9602087 SB - IM OTO - NOTNLM OT - Tetralogy of Fallot COIS- Competing interests: None declared. EDAT- 2026/04/21 13:11 MHDA- 2026/04/21 13:11 CRDT- 2026/04/20 21:42 PHST- 2025/09/16 00:00 [received] PHST- 2026/04/02 00:00 [accepted] PHST- 2026/04/21 13:11 [medline] PHST- 2026/04/21 13:11 [pubmed] PHST- 2026/04/20 21:42 [entrez] AID - heartjnl-2025-327201 [pii] AID - 10.1136/heartjnl-2025-327201 [doi] PST - aheadofprint SO - Heart. 2026 Apr 20:heartjnl-2025-327201. doi: 10.1136/heartjnl-2025-327201. PMID- 42009301 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260622 IS - 1555-0273 (Electronic) IS - 1555-0265 (Linking) VI - 21 IP - 7 DP - 2026 Jul 1 TI - Can a Simple Trapezoidal Integration Approach Accurately Estimate the Supra-Critical Speed Distance Capacity of a Swimmer? PG - 831-836 LID - 10.1123/ijspp.2025-0372 [doi] AB - The 12 x 25-m swim test has become a key physiological monitoring and profiling tool within swimming networks to capture various performance insights (peak velocity, critical speed [CS], supra-CS distance capacity [D'], and anaerobic speed reserve) within one testing occasion. The D' output following the 12 x 25-m swim test is currently derived using software that requires specialised expertise, therefore inhibiting the accessibility of the test to pathways' level coaches and athletes. OBJECTIVES: The aim of the study was to determine if trapezoidal integration (TI) could simply and accurately replace the model fit method to estimate D' following the 12 x 25-m swim test and improve the accessibility of the test for a wider cohort of practitioners. METHODS: Thirty-one national-level swimmers preparing for the Paris 2024 Olympic Trials consented for their 12 x 25-m data set to be retrieved. D' was calculated using both the model fit and TI approaches. Linear regression and pearson correlations examined the strength of the relationship and a paired t test and Bland-Altman plot determined the agreement between the 2 methodologies. RESULTS: A very strong, positive relationship was found between the model fit and TI D' calculations (r = .999, R2 = .999, P < .001), with a very small, nonsignificant difference of 0.040 m (d = 0.124, P = .495). CONCLUSIONS: TI is a valid replacement for the original model fit approach to estimate D' following the 12 x 25-m swim test. The swim test will no longer require specialised software and the accessibility of the test will increase to a wider cohort of swimming practitioners. FAU - Bulte, Karla R AU - Bulte KR AUID- ORCID: 0009-0006-3363-2284 AD - Victorian Institute of Sport, Albert Park, VIC, Australia. AD - School of Exercise and Nutrition Sciences,Deakin University, Geelong, VIC, Australia. AD - Centre for Sport Research in the Institute for Physical Activity and Nutrition,Deakin University, Geelong, VIC, Australia. FAU - Mitchell, Lachlan L G AU - Mitchell LLG AUID- ORCID: 0000-0002-1621-8026 AD - Victorian Institute of Sport, Albert Park, VIC, Australia. FAU - Siegel, Rodney AU - Siegel R AUID- ORCID: 0009-0009-7277-8106 AD - School of Exercise and Nutrition Sciences,Deakin University, Geelong, VIC, Australia. FAU - Hunter, Adam AU - Hunter A AUID- ORCID: 0009-0007-4779-2593 AD - Australian Institute of Sport, Canberra, ACT, Australia. FAU - Brooks, Edward R AU - Brooks ER AUID- ORCID: 0000-0003-2649-9535 AD - Australian Institute of Sport, Canberra, ACT, Australia. FAU - Saunders, Philo U AU - Saunders PU AD - Australian Institute of Sport, Canberra, ACT, Australia. FAU - Hoffmann, Samantha M AU - Hoffmann SM AUID- ORCID: 0000-0001-8824-7531 AD - School of Exercise and Nutrition Sciences,Deakin University, Geelong, VIC, Australia. AD - Centre for Sport Research in the Institute for Physical Activity and Nutrition,Deakin University, Geelong, VIC, Australia. LA - eng PT - Journal Article DEP - 20260420 PL - United States TA - Int J Sports Physiol Perform JT - International journal of sports physiology and performance JID - 101276430 SB - IM MH - *Swimming/physiology MH - Humans MH - *Athletic Performance/physiology MH - Exercise Test MH - Area Under Curve MH - Models, Statistical MH - Male MH - Female MH - Adolescent MH - Young Adult OTO - NOTNLM OT - accessibility OT - anaerobic capacity OT - physiological profiling OT - physiological testing OT - validity EDAT- 2026/04/21 13:11 MHDA- 2026/06/16 18:34 CRDT- 2026/04/20 19:32 PHST- 2025/07/29 00:00 [received] PHST- 2025/12/15 00:00 [revised] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/06/16 18:34 [medline] PHST- 2026/04/21 13:11 [pubmed] PHST- 2026/04/20 19:32 [entrez] AID - 10.1123/ijspp.2025-0372 [doi] PST - epublish SO - Int J Sports Physiol Perform. 2026 Apr 20;21(7):831-836. doi: 10.1123/ijspp.2025-0372. Print 2026 Jul 1. PMID- 42009101 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260814 IS - 1559-2030 (Electronic) IS - 1551-7144 (Linking) VI - 165 DP - 2026 Jun TI - Protocol for Afterschool Rx 2.0: A pilot randomized crossover trial to determine the feasibility of prescriptions to afterschool care for children with cardiovascular risk factors. PG - 108307 LID - S1551-7144(26)00093-5 [pii] LID - 10.1016/j.cct.2026.108307 [doi] AB - BACKGROUND: CVD risk factors in childhood, including obesity and hypertension, can be mitigated with physical activity and a healthy diet. Existing community-based afterschool programs provide an important opportunity to increase physical activity and improve cardiovascular health, but access remains limited for many families. The Afterschool Rx program enables healthcare providers to prescribe free afterschool care for children with CVD risk factors from families at or below 250% of the federal poverty level. METHODS: This study will employ an ORBIT Phase IIb randomized crossover design to conduct a preliminary trial of Afterschool Rx. Participating children (ages 5-11 years; n = 48) will be randomly assigned to receive a voucher for afterschool care at existing community-based programs (e.g., YMCA, Boys & Girls Clubs) along with enrollment assistance, in either the fall or spring semester, with the opposite semester serving as the comparison period (treatment as usual). Primary outcomes will examine the reach and potential for dissemination of the program using the PRISM/RE-AIM framework. Exploratory outcomes include health behaviors (e.g., physical activity, sedentary behavior, sleep, screen use, and diet quality) and cardiovascular health indicators (e.g., cardiorespiratory fitness, blood glucose, blood pressure, HbA1c, and cholesterol levels). Exploratory analyses will examine within-person differences in change between semesters. DISCUSSION: This study will be the first randomized controlled trial to evaluate the reach and feasibility of disseminating afterschool care prescriptions as a clinical strategy for addressing cardiovascular risk factors. Results will inform further testing and development of the Afterschool Rx intervention. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - von Klinggraeff, Lauren AU - von Klinggraeff L AD - Augusta University, School of Public Health, Department of Community and Behavioral Health Sciences, United States of America. Electronic address: lvonklinggraeff@augusta.edu. FAU - Harris, Ryan A AU - Harris RA AD - Augusta University, Medical College of Georgia, Georgia Prevention Institute, United States of America. Electronic address: RYHARRIS@augusta.edu. FAU - Estabrooks, Paul AU - Estabrooks P AD - University of Utah, College of Health, Department of Health and Kinesiology, United States of America. Electronic address: paul.estabrooks@health.utah.edu. FAU - Coughlin, Steven AU - Coughlin S AD - Augusta University, School of Public Health, Department of Biostatistics, Data Science, & Epidemiology, United States of America. Electronic address: SCOUGHLIN@augusta.edu. FAU - Armstrong, Bridget AU - Armstrong B AD - University of South Carolina, Arnold School of Public Health, Department of Exercise Science, United States of America. Electronic address: BA12@mailbox.sc.edu. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260419 PL - United States TA - Contemp Clin Trials JT - Contemporary clinical trials JID - 101242342 SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - Blood Pressure MH - *Cardiovascular Diseases/prevention & control MH - Cross-Over Studies MH - Diet, Healthy MH - Exercise MH - Feasibility Studies MH - Health Behavior MH - Heart Disease Risk Factors MH - Hypertension MH - *Pediatric Obesity/prevention & control/therapy MH - Pilot Projects MH - Poverty MH - Randomized Controlled Trials as Topic MH - Schools MH - Screen Time MH - Sedentary Behavior MH - Sleep MH - Clinical Trials, Phase II as Topic OTO - NOTNLM OT - Afterschool OT - Cardiovascular risk factors OT - Health behaviors OT - Intervention OT - Physical activity OT - RE-AIM framework OT - children OT - intervetion OT - out of school time OT - pilot study OT - youth COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/21 13:11 MHDA- 2026/05/15 00:31 CRDT- 2026/04/20 19:11 PHST- 2025/09/05 00:00 [received] PHST- 2026/03/19 00:00 [revised] PHST- 2026/04/11 00:00 [accepted] PHST- 2026/05/15 00:31 [medline] PHST- 2026/04/21 13:11 [pubmed] PHST- 2026/04/20 19:11 [entrez] AID - S1551-7144(26)00093-5 [pii] AID - 10.1016/j.cct.2026.108307 [doi] PST - ppublish SO - Contemp Clin Trials. 2026 Jun;165:108307. doi: 10.1016/j.cct.2026.108307. Epub 2026 Apr 19. PMID- 42008885 OWN - NLM STAT- MEDLINE DCOM- 20260608 LR - 20260608 IS - 1532-8430 (Electronic) IS - 0022-0736 (Linking) VI - 96 DP - 2026 May-Jun TI - Prevalence and clinical significance of T-wave inversion on electrocardiogram in patients with exercise-induced laryngeal obstruction (EILO): A cross-sectional study. PG - 154261 LID - S0022-0736(26)00078-6 [pii] LID - 10.1016/j.jelectrocard.2026.154261 [doi] AB - AIMS: We aimed to systematically evaluate standard 12‑lead electrocardiograms (ECG) in young individuals with exercise-induced laryngeal obstruction (EILO), with a special focus on the prevalence and clinical significance of T-wave inversion (TWI). METHODS AND RESULTS: 235 individuals (mean age 16.7 years, 85% females) presenting to the EILO Clinic, underwent 709 high-intensity cardiopulmonary exercise treadmill testing with continuous visualization of the larynx (CLE- Continuous Laryngoscopy Exercise). There was no adverse event during exercise tests. The prevalence of TWI (negatively deflected T-wave >/=1 mm (0.1 mV amplitude) in any 2 contiguous leads excluding aVR, III, and V1) was 42.6% (18.7% isolated in the inferior wall leads, 13.2% in the inferolateral leads, 5.1% in both the inferior and anterior leads, 3% both in the inferior and anteroseptal leads, 2.1% isolated in anteroseptal leads and 0.9% isolated in anterior wall leads). Age, body height and weight, exercise duration and peak oxygen uptake did not differ between individuals with versus without TWI (all p > 0.05). There was a trend towards lower total CLE score in individuals with TWI (4.2 vs 4.5, p = 0.070). Individuals with TWI had higher resting heart rate (98 vs 95 bpm, p = 0.05), shorter PQ-interval (124 vs 129 ms, p = 0.020) and achieved higher peak heart rate (193 vs 189 bpm, p = 0.005) and metabolic equivalents during exercise (13.4 vs 12.9, p = 0.028). CONCLUSIONS: High-intensity CLE-test in individuals with EILO was not associated with any adverse cardiac findings. TWI was highly prevalent and particularly observed in the inferior or inferolateral wall leads but had no association with energetic decline or cardiac dysfunction. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Saeed, Sahrai AU - Saeed S AD - Department of Heart Disease, Haukeland University Hospital, Bergen, Norway; Department of Cardiology, Oslo University Hospital Ullevaal, Oslo, Norway; Faculty of Medicine, University of Oslo, Oslo, Norway. Electronic address: sahrai_saeed@hotmail.com. FAU - Carlsen, Petter AU - Carlsen P AD - Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Bergen, Norway; Department of Paediatric and Adolescent Medicine, Haukeland University Hospital, Bergen, Norway. FAU - Muralitharan, Praveen AU - Muralitharan P AD - Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Bergen, Norway; Department of Paediatric and Adolescent Medicine, Haukeland University Hospital, Bergen, Norway. FAU - Solli, Petrine V AU - Solli PV AD - Department of Paediatric and Adolescent Medicine, Haukeland University Hospital, Bergen, Norway; Faculty of Health and Social Sciences, Western Norway University of Applied Science, Bergen, Norway. FAU - Kvidaland, Haakon Kristian AU - Kvidaland HK AD - Department of Paediatric and Adolescent Medicine, Haukeland University Hospital, Bergen, Norway; Faculty of Health and Social Sciences, Western Norway University of Applied Science, Bergen, Norway. FAU - Vollsaeter, Maria AU - Vollsaeter M AD - Department of Clinical Medicine, Faculty of Medicine, University of Bergen, Bergen, Norway; Department of Paediatric and Adolescent Medicine, Haukeland University Hospital, Bergen, Norway. FAU - Halvorsen, Thomas AU - Halvorsen T AD - Department of Paediatric and Adolescent Medicine, Haukeland University Hospital, Bergen, Norway; Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway. FAU - Clemm, Hege H AU - Clemm HH AD - Department of Paediatric and Adolescent Medicine, Haukeland University Hospital, Bergen, Norway; Department of Sports Medicine, Norwegian School of Sport Sciences, Oslo, Norway. LA - eng PT - Journal Article DEP - 20260416 PL - United States TA - J Electrocardiol JT - Journal of electrocardiology JID - 0153605 SB - IM MH - Humans MH - *Electrocardiography/statistics & numerical data/methods MH - Female MH - *Exercise Test/statistics & numerical data MH - Cross-Sectional Studies MH - Prevalence MH - Adolescent MH - Male MH - *Airway Obstruction/epidemiology/physiopathology/diagnosis MH - Reproducibility of Results MH - Young Adult OTO - NOTNLM OT - Continuous laryngoscopy exercise OT - Electrocardiogram OT - Exercise-induced laryngeal obstruction OT - T-wave inversion COIS- Declaration of competing interest There are no conflicts of interest for any authors related to this work. EDAT- 2026/04/21 13:10 MHDA- 2026/06/08 19:42 CRDT- 2026/04/20 18:01 PHST- 2025/12/04 00:00 [received] PHST- 2026/03/28 00:00 [revised] PHST- 2026/04/11 00:00 [accepted] PHST- 2026/06/08 19:42 [medline] PHST- 2026/04/21 13:10 [pubmed] PHST- 2026/04/20 18:01 [entrez] AID - S0022-0736(26)00078-6 [pii] AID - 10.1016/j.jelectrocard.2026.154261 [doi] PST - ppublish SO - J Electrocardiol. 2026 May-Jun;96:154261. doi: 10.1016/j.jelectrocard.2026.154261. Epub 2026 Apr 16. PMID- 42008539 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1553-7404 (Electronic) IS - 1553-7390 (Print) IS - 1553-7390 (Linking) VI - 22 IP - 4 DP - 2026 Apr TI - Examining the association between fetal HLA-C, maternal KIR haplotypes and birth weight. PG - e1012102 LID - 10.1371/journal.pgen.1012102 [doi] LID - e1012102 AB - Human birth weight is under stabilizing selection, seeking balance between extremes of high and low, thereby reducing fetal and maternal perinatal mortality risk. Certain combinations of maternal killer immunoglobulin-like receptor (KIR) and paternally derived fetal human leuokocyte antigen-C (HLA-C) alleles were previously associated with higher risk of high and low birth weight in a study with limited sample size (n = 1,316). Using recently developed methods to impute HLA and KIR haplotypes using single nucleotide polymorphism (SNP) genotype data, we tested associations of fetal HLA and maternal KIR genotypes with offspring birth weight in a large sample. We imputed KIR haplotypes using the KIR*IMP imputation software in 10,602 mother-offspring pairs of European descent from singleton pregnancies from five studies. Using mixed linear regression models to account for mothers with multiple children, we tested associations between maternal KIR A vs B haplotypes (AA, AB/BA, BB genotypes) as well as copy number of activating receptor gene KIR2DS1 (0, 1, 2 copies of the gene) in the presence of fetal HLA C1/C2 alleles, and offspring birth weight. Associations were analyzed in each cohort before performing a meta-analysis to estimate the interaction effects between maternal KIR and fetal HLA-C2 on birth weight across the entire sample. The KIR haplotypes achieved imputation accuracy estimated at >95% in most of the cohorts. No interaction effects were observed between either the maternal A vs. B haplotype or the maternal KIR2DS1 locus and fetal HLA-C. When specifically trying to replicate the previously associated combination of maternal KIR2DS1 and paternally inherited fetal HLA-C2, there was a negligible change in offspring birth weight for each additional KIR2DS1 allele and HLA-C2 of paternal origin (7g lower birth weight per allele [95% CI: -54, 40], P = 0.78). We found little evidence of association between birth weight and maternal KIR haplotypes or fetal HLA-C2 and were unable to replicate previously reported findings. Our observations reinforce the importance of replication and the use of large sample sizes in the validation of genetic associations. CI - Copyright: (c) 2026 Decina et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Decina, Caitlin Stephanie AU - Decina CS AUID- ORCID: 0009-0003-1106-0519 AD - Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom. AD - Centre for Population and Disease Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. FAU - Warrington, Nicole M AU - Warrington NM AD - Centre for Population and Disease Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. AD - Frazer Institute, University of Queensland, Brisbane, Queensland, Australia. FAU - Beaumont, Robin N AU - Beaumont RN AD - Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom. FAU - Bian, Beilei AU - Bian B AD - Centre for Population and Disease Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. FAU - Brito Nunes, Caroline AU - Brito Nunes C AUID- ORCID: 0000-0002-2654-1679 AD - Centre for Population and Disease Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. FAU - Wang, Geng AU - Wang G AD - Centre for Population and Disease Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. FAU - Lowe, William L Jr AU - Lowe WL Jr AD - Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America. FAU - Squire, David AU - Squire D AUID- ORCID: 0000-0001-6738-8271 AD - Department of Mathematics and Statistics, School of Mathematics and Statistics, University of Melbourne, Melbourne, Victoria, Australia. AD - Melbourne Integrative Genomics, University of Melbourne, Melbourne, Victoria, Australia. FAU - Vukcevic, Damjan AU - Vukcevic D AUID- ORCID: 0000-0001-7780-9586 AD - Department of Mathematics and Statistics, School of Mathematics and Statistics, University of Melbourne, Melbourne, Victoria, Australia. AD - Melbourne Integrative Genomics, University of Melbourne, Melbourne, Victoria, Australia. AD - Department of Econometrics and Business Statistics, Monash University, Melbourne, Australia. FAU - Leslie, Stephen AU - Leslie S AD - Department of Mathematics and Statistics, School of Mathematics and Statistics, University of Melbourne, Melbourne, Victoria, Australia. FAU - Freathy, Rachel M AU - Freathy RM AUID- ORCID: 0000-0003-4152-2238 AD - Department of Clinical and Biomedical Sciences, Faculty of Health and Life Sciences, University of Exeter, Exeter, United Kingdom. FAU - Evans, David M AU - Evans DM AD - Centre for Population and Disease Genomics, Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. AD - Frazer Institute, University of Queensland, Brisbane, Queensland, Australia. AD - Medical Research Council Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom. LA - eng PT - Journal Article DEP - 20260420 PL - United States TA - PLoS Genet JT - PLoS genetics JID - 101239074 RN - 0 (HLA-C Antigens) RN - 0 (Receptors, KIR) RN - 0 (KIR2DS1 protein, human) SB - IM UOF - medRxiv. 2025 Apr 10:2025.04.09.25325484. doi: 10.1101/2025.04.09.25325484. PMID: 40297441 MH - Humans MH - *HLA-C Antigens/genetics MH - Haplotypes/genetics MH - *Receptors, KIR/genetics MH - Female MH - *Birth Weight/genetics MH - Pregnancy MH - Polymorphism, Single Nucleotide MH - Infant, Newborn MH - Fetus/metabolism MH - Alleles MH - Genotype MH - Male MH - Adult PMC - PMC13095029 COIS- The authors have declared that no competing interests exist. EDAT- 2026/04/21 13:10 MHDA- 2026/04/21 13:11 PMCR- 2026/04/20 CRDT- 2026/04/20 13:53 PHST- 2025/04/21 00:00 [received] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/04/21 13:11 [medline] PHST- 2026/04/21 13:10 [pubmed] PHST- 2026/04/20 13:53 [entrez] PHST- 2026/04/20 00:00 [pmc-release] AID - PGENETICS-D-25-00434 [pii] AID - 10.1371/journal.pgen.1012102 [doi] PST - epublish SO - PLoS Genet. 2026 Apr 20;22(4):e1012102. doi: 10.1371/journal.pgen.1012102. eCollection 2026 Apr. PMID- 42007891 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260928 IS - 1552-5732 (Electronic) IS - 0890-3344 (Linking) VI - 42 IP - 3 DP - 2026 Aug TI - Perceptions of Racism and Discrimination in Birthing Centers: Implications for Exclusive Breastfeeding Practices Among Black Mothers. PG - 675-681 LID - 10.1177/08903344261430461 [doi] AB - BACKGROUND: Racial disparities in breastfeeding persist, with Black mothers experiencing significantly lower exclusive breastfeeding rates compared with White mothers. Limited research has examined how institutional bias and discrimination within birthing centers affect breastfeeding decisions, creating a gap in understanding the role of these environments in perpetuating lactation inequities. METHODS: A basic qualitative study guided by the social ecological model explored how perceived racism and discrimination in birthing centers shape exclusive breastfeeding initiation and duration among Black mothers. Ten participants were recruited through purposive sampling and completed semistructured virtual interviews. Data were coded inductively using ATLAS.ti 9 and verified through analyst triangulation and Krippendorff's alpha to ensure reliability. RESULTS: Four interconnected themes emerged: (1) individual level-birth trauma and pain dismissal reduced confidence in breastfeeding; (2) interpersonal level-racialized communication barriers and lack of lactation support undermined trust; (3) community level-formula-first norms and underrepresentation of Black lactation professionals limited culturally relevant care; and (4) institutional level-rigid policies and privacy violations reinforced inequitable treatment. CONCLUSION: Perceived racism and discrimination in birthing centers negatively influence Black mothers' breastfeeding experiences and outcomes. Equity-driven organizational reforms, anti-racist training, and diversification of the lactation workforce are essential to promote breastfeeding equity and improve maternal-infant health. FAU - Conner, Natashia Le'Nee AU - Conner NL AD - Walden University, Minneapolis, MN, USA. AD - Founder & Executive Director, The BLACK Collaborative Inc., Cincinnati, OH, USA. FAU - Langley, Cheri N AU - Langley CN AD - Walden University, Minneapolis, MN, USA. FAU - Arcelay Rojas, Yitza AU - Arcelay Rojas Y AD - Walden University, Minneapolis, MN, USA. LA - eng PT - Journal Article DEP - 20260420 PL - United States TA - J Hum Lact JT - Journal of human lactation : official journal of International Lactation Consultant Association JID - 8709498 SB - IM MH - Humans MH - Female MH - *Breast Feeding/psychology/ethnology MH - *Racism/psychology MH - Adult MH - *Black or African American/psychology/statistics & numerical data MH - *Mothers/psychology/statistics & numerical data MH - *Birthing Centers/standards/organization & administration/statistics & numerical data MH - Qualitative Research MH - *Perception OTO - NOTNLM OT - birthing centers OT - breastfeeding OT - exclusive breastfeeding OT - health-care discrimination OT - lactation OT - maternal health services OT - patient-provider relationship OT - qualitative study OT - racial discrimination OT - social-ecological model COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/04/21 13:10 MHDA- 2026/09/25 17:32 CRDT- 2026/04/20 10:02 PHST- 2026/09/25 17:32 [medline] PHST- 2026/04/21 13:10 [pubmed] PHST- 2026/04/20 10:02 [entrez] AID - 10.1177/08903344261430461 [doi] PST - ppublish SO - J Hum Lact. 2026 Aug;42(3):675-681. doi: 10.1177/08903344261430461. Epub 2026 Apr 20. PMID- 42007488 OWN - NLM STAT- Publisher LR - 20260421 IS - 1552-6372 (Electronic) IS - 1524-8399 (Linking) DP - 2026 Apr 20 TI - Development and Pilot Testing of a Novel Methodology to Examine the Food, Waste, and Packaging in Australian Schoolchildren's Lunchboxes. PG - 15248399261435623 LID - 10.1177/15248399261435623 [doi] AB - Most children in Australia bring a packed lunch from home for consumption at school, yet few studies have explored the environmental outcomes of lunchbox contents. This study presents a novel audit methodology that combines food photography with a custom-designed survey developed in REDCap, supported by a detailed coding guide, to assess lunchbox contents, including food, estimated waste, and packaging types. To pilot test the audit tool, two school sites in high socioeconomic regions in South Australia participated. Lunchbox photographs were captured at two time points on a single day (before and after consumption) by the student researcher at the preschool and by a class teacher at the primary school. Independent coding was completed by two researchers, with inter-coder reliability assessed. Among the 40 lunchboxes sampled, the average contents included one vegetable, one to two fruits, one to three grain or cereal items, one dairy product, and one to two snack items. Intraclass correlation coefficient estimates indicated excellent agreement between coders. Food photography on-site, combined with subsequent coding off-site, offers a practical and objective method for assessing food, waste, and packaging in school lunchboxes, while placing minimal burden on participants. Lunchboxes are essential to the nutrition of school-aged children and have sustainability implications. This dual-focus methodology lays the groundwork for future research with larger sample sizes, aiming to inform the development of interventions that improve both the quality of foods in lunchboxes and their environmental impact. FAU - Lalchandani, Neha AU - Lalchandani N AUID- ORCID: 0000-0002-6359-1704 AD - School of Public Health, The University of Adelaide, Adelaide, South Australia, Australia. AD - School of Health and Social Development, Global Centre for Preventive Health and Nutrition (GLOBE), Institute for Health Transformation, Faculty of Health, Deakin University, Geelong, Victoria, Australia. FAU - Miller, Caroline AU - Miller C AD - School of Public Health, The University of Adelaide, Adelaide, South Australia, Australia. AD - Health Policy Centre, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia, Australia. FAU - Giles, Lynne AU - Giles L AD - School of Public Health, The University of Adelaide, Adelaide, South Australia, Australia. FAU - Hendrikx, Jo AU - Hendrikx J AD - KESAB Environmental Solutions, Adelaide, South Australia, Australia. FAU - Crabb, Shona AU - Crabb S AD - School of Public Health, The University of Adelaide, Adelaide, South Australia, Australia. FAU - Moores, Carly AU - Moores C AD - Adelaide Dental School, University of Adelaide, Adelaide, Australia. FAU - Hume, Clare AU - Hume C AD - School of Public Health, The University of Adelaide, Adelaide, South Australia, Australia. LA - eng PT - Journal Article DEP - 20260420 PL - United States TA - Health Promot Pract JT - Health promotion practice JID - 100890609 SB - IM OTO - NOTNLM OT - Australia OT - child OT - food photography OT - food waste OT - inter-coder reliability OT - lunch OT - lunchbox OT - lunchbox audit OT - packaging OT - schools EDAT- 2026/04/20 13:10 MHDA- 2026/04/20 13:10 CRDT- 2026/04/20 07:56 PHST- 2026/04/20 13:10 [medline] PHST- 2026/04/20 13:10 [pubmed] PHST- 2026/04/20 07:56 [entrez] AID - 10.1177/15248399261435623 [doi] PST - aheadofprint SO - Health Promot Pract. 2026 Apr 20:15248399261435623. doi: 10.1177/15248399261435623. PMID- 42006748 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260421 LR - 20260813 IS - 2753-4294 (Electronic) IS - 2753-4294 (Linking) VI - 4 IP - 2 DP - 2026 TI - Feasibility and acceptability of a school-based Group Motivational Interviewing intervention to reduce sugar-sweetened beverages among young people in East London: DISS feasibility study. PG - e003961 LID - 10.1136/bmjph-2025-003961 [doi] LID - e003961 AB - INTRODUCTION: Young people consume sugar-sweetened beverages (SSBs) regularly which increases their risk of obesity and dental caries. School-based interventions can reduce the consumption of SSBs. This study aimed to assess the feasibility and acceptability of a Group Motivational Interviewing intervention delivered by teachers to reduce SSB consumption among 12-13 year-olds in secondary schools in East London to prevent weight gain. METHODS: A feasibility study with an embedded exploratory mixed-methods design was conducted. Participants included children aged 12-13 years old and five teachers. Intervention was co-developed with teachers and young people, which included three components: Group Motivational Interviewing training to teachers to deliver two sessions to young people, a mobile application for young people was developed to support them with behaviour change and a resource pack for parents/carers. The main outcome measures at baseline and follow-up were anthropometric, dietary and lifestyle behaviours. Feasibility measures included recruitment and retention rates, intervention delivery and acceptability. Thematic analysis was used to analyse the qualitative data and descriptive analysis for the quantitative data. RESULTS: One secondary school was recruited despite attempting to recruit six schools, and a second school was recruited to co-develop the intervention. Five teachers, 49 young people and their parents (n=26) were recruited in one school. At follow-up (n=47), SSB consumption decreased, and water consumption increased, but this was based on a limited dietary recall sample. The main challenge was the recruitment of schools due to limited school resources and organisational factors. In terms of acceptability, once young people were recruited, they reported positive attitudes towards the intervention whereas teachers found it less feasible due to structural constraints. CONCLUSIONS: Although the intervention was acceptable and feasible in school settings, there were significant challenges in recruitment of schools. The intervention was more acceptable for students than teachers. This study showed the importance of conducting feasibility studies prior to a large trial. CI - Copyright (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Yusuf, Huda AU - Yusuf H AUID- ORCID: 0000-0002-1552-7708 AD - Centre for Dental Public Health and Primary Care, Institute of Dentistry, Queen Mary University of London, London, UK. FAU - Steed, Elizabeth AU - Steed E AD - Wolfson Institute of Population Health, Centre for Primary Care, Queen Mary University of London, London, UK. FAU - Valenzuela, Maria Josefina AU - Valenzuela MJ AUID- ORCID: 0000-0002-6519-6708 AD - Centre for Dental Public Health and Primary Care, Institute of Dentistry, Queen Mary University of London, London, UK. LA - eng PT - Journal Article DEP - 20260413 PL - England TA - BMJ Public Health JT - BMJ public health JID - 9918697578906676 PMC - PMC13084870 OTO - NOTNLM OT - Obesity OT - Primary Prevention OT - Public Health COIS- None declared. EDAT- 2026/04/20 13:10 MHDA- 2026/04/20 13:11 PMCR- 2026/04/13 CRDT- 2026/04/20 07:49 PHST- 2025/09/03 00:00 [received] PHST- 2026/03/20 00:00 [accepted] PHST- 2026/04/20 13:11 [medline] PHST- 2026/04/20 13:10 [pubmed] PHST- 2026/04/20 07:49 [entrez] PHST- 2026/04/13 00:00 [pmc-release] AID - bmjph-2025-003961 [pii] AID - 10.1136/bmjph-2025-003961 [doi] PST - epublish SO - BMJ Public Health. 2026 Apr 13;4(2):e003961. doi: 10.1136/bmjph-2025-003961. eCollection 2026. PMID- 42006403 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260420 LR - 20260813 IS - 2212-1366 (Print) IS - 2212-1374 (Electronic) IS - 2212-1366 (Linking) VI - 58 DP - 2026 Jun TI - Health-related quality of life and physical activity in children with Multiple Osteochondromas. PG - 100759 LID - 10.1016/j.jbo.2026.100759 [doi] LID - 100759 AB - OBJECTIVES: To evaluate health-related quality of life (HRQOL) and physical activity level (PAL) in children and adolescents with Multiple Osteochondromas (MO) and to identify factors associated with these outcomes. STUDY DESIGN: Cross-sectional survey of Dutch patients aged 4-18 years recruited through the national MO expertise center and the patient association. Validated, age-specific questionnaires assessed HRQOL (TAP/TAC/TAAQOL), PAL (Baecke), pain, functional disability, and psychosocial and sociodemographic variables. Multiple linear regression, guided by the International Classification of Functioning framework, examined associated variables with the mental and physical HRQOL components and with PAL. RESULTS: A total of 134 participants (53% male; mean age +/- SD, 11.4 +/- 3.7 years) completed the survey. Compared with population norms, patients with MO scored significantly lower on physical HRQOL but not consistently lower on mental HRQOL. Significant gender differences emerged in specific HRQOL domains across multiple age groups. Mean PAL was also reduced (7.35 +/- 1.01, p < 0.001) compared with healthy peers. Physical HRQOL (R(2) = 0.727, p < 0.001) was negatively associated with pain and positively with externalizing behavior. The mental HRQOL model (R(2) = 0.648, p < 0.001) showed the strongest negative associations with internalizing problems and functional disability. Having >/= 5 surgeries was the only independent predictor of PAL, explaining 4.4% of its variance. CONCLUSIONS: The pediatric MO population reports significantly lower physical HRQOL and PAL, but not consistently lower mental HRQOL than healthy peers. Specific gender differences were observed across multiple domains. The associations identified in this study call for a multidisciplinary approach to MO management that emphasizes pain control, functional rehabilitation, and psychosocial support. CI - (c) 2026 The Authors. Published by Elsevier GmbH. FAU - Amajjar, Ihsane AU - Amajjar I AD - Department of Rehabilitation Medicine, CAPHRI, Maastricht University, Maastricht, The Netherlands. AD - Department of Orthopaedic Surgery, OLVG, Amsterdam, The Netherlands. FAU - Willigenburg, Nienke W AU - Willigenburg NW AD - Department of Orthopaedic Surgery, OLVG, Amsterdam, The Netherlands. FAU - Langenberg, Benedikt G AU - Langenberg BG AD - Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, The Netherlands. FAU - Ham, S John AU - Ham SJ AD - Department of Orthopaedic Surgery, OLVG, Amsterdam, The Netherlands. FAU - Smeets, Rob J E M AU - Smeets RJEM AD - Department of Rehabilitation Medicine, CAPHRI, Maastricht University, Maastricht, The Netherlands. AD - Pain in Motion International Research Group, www.paininmotion.be, Brussels, Belgium. AD - Clinics in Revalidatie (CIR), Eindhoven, The Netherlands. LA - eng PT - Journal Article DEP - 20260402 PL - Netherlands TA - J Bone Oncol JT - Journal of bone oncology JID - 101610292 PMC - PMC13087577 OTO - NOTNLM OT - Exostoses OT - Multiple hereditary OT - Multiple osteochondromas OT - Physical activity OT - Primary bone tumours OT - Quality of life COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/20 13:10 MHDA- 2026/04/20 13:11 PMCR- 2026/04/02 CRDT- 2026/04/20 07:47 PHST- 2025/12/23 00:00 [received] PHST- 2026/03/30 00:00 [revised] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/04/20 13:11 [medline] PHST- 2026/04/20 13:10 [pubmed] PHST- 2026/04/20 07:47 [entrez] PHST- 2026/04/02 00:00 [pmc-release] AID - S2212-1374(26)00021-7 [pii] AID - 100759 [pii] AID - 10.1016/j.jbo.2026.100759 [doi] PST - epublish SO - J Bone Oncol. 2026 Apr 2;58:100759. doi: 10.1016/j.jbo.2026.100759. eCollection 2026 Jun. PMID- 42005301 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260421 LR - 20260927 IS - 2472-1972 (Electronic) IS - 2472-1972 (Linking) VI - 10 IP - 5 DP - 2026 May TI - Longitudinal dynamics of fasting plasma uridine in the preclinical stage of type 1 diabetes. PG - bvag059 LID - 10.1210/jendso/bvag059 [doi] LID - bvag059 AB - CONTEXT: Elevated blood uridine levels have been reported in children with newly diagnosed type 1 diabetes (T1D); however, their relevance to disease onset remains unclear. OBJECTIVE: To explore whether changes in plasma uridine are associated with the development of T1D in at-risk individuals. METHODS: Pre- and post-T1D-onset oral glucose tolerance test plasma samples from 45 cases and matched controls in the Diabetes Prevention Trial-Type 1 trial were examined for uridine concentrations using LC-MS/MS. Cases with age > 21, BMI > 25, HbA1c > 5.7%, or interval from screening to T1D diagnosis < 1 year were excluded due to the potential confounding effects of aging, obesity, and insulin resistance on uridine homeostasis. Twenty-three matched case-control pairs were used to evaluate associations between uridine levels and T1D risk. RESULTS: Individuals who later developed T1D (cases) exhibited an increase in plasma uridine around the onset of T1D (5.03 +/- 0.86 microM before and 6.10 +/- 1.40 microM after T1D diagnosis, P = .001), whereas individuals who did not develop T1D (controls) showed a decrease (6.20 +/- 1.32 microM at Visit 1 and 5.20 +/- 1.33 microM at Visit 2, P < .001). The receiver operating characteristic curve indicates that baseline fasting uridine demonstrates discriminatory performance for T1D (area under the curve = 0.773). Mixed-effects modeling identifies a significant time x group interaction, with group-specific uridine dynamics evident prior to T1D onset in humans. CONCLUSION: Our findings suggest that fasting uridine changes precede T1D onset and may serve as an early biomarker. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Endocrine Society. FAU - Xiong, Qiutang AU - Xiong Q AD - Department of Diabetes and Cancer Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA. FAU - Jang, Chelsea AU - Jang C AD - Department of Diabetes and Cancer Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA. FAU - Wang, Kevin AU - Wang K AD - Department of Diabetes and Cancer Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA. FAU - Fu, Ling AU - Fu L AD - Department of Diabetes and Cancer Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA. FAU - Ding, Lu AU - Ding L AD - Department of Diabetes and Cancer Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA. FAU - Wang, Zhao V AU - Wang ZV AD - Department of Diabetes and Cancer Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA. FAU - Wang, Ping AU - Wang P AD - Department of Diabetes, Endocrinology & Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA. FAU - Deng, Yingfeng AU - Deng Y AUID- ORCID: 0000-0003-1314-5105 AD - Department of Diabetes and Cancer Metabolism, Arthur Riggs Diabetes and Metabolism Research Institute, Beckman Research Institute, City of Hope National Medical Center, Duarte, CA 91010, USA. LA - eng GR - R01 DK140109/DK/NIDDK NIH HHS/United States GR - R01 HL171309/HL/NHLBI NIH HHS/United States GR - R01 DK126975/DK/NIDDK NIH HHS/United States GR - R01 HL137723/HL/NHLBI NIH HHS/United States GR - R56 DK140109/DK/NIDDK NIH HHS/United States GR - R01 HL156951/HL/NHLBI NIH HHS/United States GR - P30 CA033572/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20260317 PL - United States TA - J Endocr Soc JT - Journal of the Endocrine Society JID - 101697997 PMC - PMC13089441 OTO - NOTNLM OT - DPT-1 study OT - fasting uridine OT - onset of type 1 diabetes OT - type 1 diabetes EDAT- 2026/04/20 13:10 MHDA- 2026/04/20 13:11 PMCR- 2026/03/17 CRDT- 2026/04/20 07:37 PHST- 2026/01/21 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/04/20 13:11 [medline] PHST- 2026/04/20 13:10 [pubmed] PHST- 2026/04/20 07:37 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - bvag059 [pii] AID - 10.1210/jendso/bvag059 [doi] PST - epublish SO - J Endocr Soc. 2026 Mar 17;10(5):bvag059. doi: 10.1210/jendso/bvag059. eCollection 2026 May. PMID- 42005136 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260421 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 3 DP - 2026 Mar TI - Artificial Placenta and Partial Ectogenesis for Extremely Preterm Infants: A Narrative Review. PG - e105357 LID - 10.7759/cureus.105357 [doi] LID - e105357 AB - Extremely preterm births at the edge of viability are associated with high mortality and significant long-term morbidity. This is largely due to the sudden and involuntary shift from fetal placental support to neonatal lung breathing, accompanied by systemic organ injury. Between 22 and 24 weeks of gestation, the fetal lungs, brain, and metabolic regulatory systems are not biologically prepared for extrauterine life. As a result, extremely preterm infants are highly vulnerable to ventilator-induced lung injury, oxygen toxicity, hemodynamic instability, and inflammatory cascades that contribute to bronchopulmonary dysplasia and neurological injury. Modern neonatal intensive care can provide respiratory, hemodynamic, nutritional, and supportive care; however, it cannot fully reproduce fetal physiology. Artificial placenta and artificial womb technologies, often described as partial ectogenesis, aim to provide extracorporeal gas exchange through the umbilical vessels while maintaining fluid-filled lungs in a closed, thermoregulated, amniotic-like environment to support fetal physiology after delivery. Preclinical ovine models using pumpless arteriovenous circuits and sealed fluid environments have demonstrated the feasibility of supporting fetuses at developmental stages comparable to human periviability for prolonged periods while maintaining stable fetal circulation. However, major translational barriers remain, including reliable umbilical vascular access, development of ultra-low-resistance oxygenators that function at fetal flows and pressures, hemocompatibility and anticoagulation management, infection control during prolonged extracorporeal support, and the inability to replicate the placenta's endocrine and metabolic functions necessary for normal fetal growth and organ maturation. The ethical implications are also substantial. Partial ectogenesis may alter how clinicians and society approach viability, influence thresholds for resuscitation and periviability counseling, complicate consent in high-stress emergency settings, and generate distributive justice concerns if access remains limited to highly specialized centers. This narrative review summarizes the physiological rationale, major preclinical evidence, translational challenges, and ethical considerations surrounding artificial placenta and partial ectogenesis technologies for extremely preterm infants. CI - Copyright (c) 2026, Abdulraheem et al. FAU - Abdulraheem, Tasneem A AU - Abdulraheem TA AD - Pediatrics, Jordanian Royal Medical Services, Amman, JOR. LA - eng PT - Journal Article PT - Review DEP - 20260317 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13084614 OTO - NOTNLM OT - artificial placenta OT - artificial womb OT - extreme prematurity OT - partial ectogenesis OT - periviable birth COIS- Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/04/20 13:10 MHDA- 2026/04/20 13:11 PMCR- 2026/03/17 CRDT- 2026/04/20 07:36 PHST- 2026/03/16 00:00 [accepted] PHST- 2026/04/20 13:11 [medline] PHST- 2026/04/20 13:10 [pubmed] PHST- 2026/04/20 07:36 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - 10.7759/cureus.105357 [doi] PST - epublish SO - Cureus. 2026 Mar 17;18(3):e105357. doi: 10.7759/cureus.105357. eCollection 2026 Mar. PMID- 42004165 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260421 LR - 20260421 IS - 2190-572X (Print) IS - 2190-5738 (Electronic) IS - 2190-5738 (Linking) VI - 16 IP - 5 DP - 2026 May TI - Integrated multi-omics analysis identifies TBC1D10C as an NK- and T cell-associated diagnostic biomarker in childhood obesity. PG - 165 LID - 10.1007/s13205-026-04818-8 [doi] LID - 165 AB - Childhood obesity is a growing global health crisis associated with an increased risk of metabolic and cardiovascular diseases in adulthood. While accumulating evidence implicates immune dysregulation in obesity pathogenesis, the specific transcriptional alterations of immune cells, particularly NK cells and T cells in the context of childhood obesity, and their potential as non-invasive diagnostic biomarkers, remain largely unexplored. Here, we investigated the transcriptional alterations of NK cells and T cells in childhood obesity and evaluated their potential as non-invasive diagnostic biomarkers. To this end, we integrated bulk RNA-seq datasets (GSE205668 and GSE87493), adipose single-cell RNA-seq data (GSE159960), and blood qPCR validation to identify NK- and T-cell-related diagnostic biomarkers for childhood obesity. Differential expression analysis and WGCNA were applied to the bulk datasets to derive obesity-associated candidates, and single-cell RNA-seq was used to define immune-cell composition, infer NK-cell pseudotemporal dynamics, and quantify cell-cell communication. Genes shared between the bulk and single-cell analyses were prioritized using an ensemble machine-learning workflow comprising 110 model configurations and five feature-selection methods. TBC1D10C expression was validated by qPCR in an independent cohort of 29 children. Transcriptome-based analyses indicated reduced relative representation of NK cells and T cells in childhood obesity, with altered transcriptional programs and inferred impairment of NK-CD4 + T-cell communication. A 13-gene NK- and T-cell-based diagnostic signature was derived, and TBC1D10C was consistently prioritized by all feature-selection methods. The signature showed good discrimination between childhood obesity and controls across datasets (AUC 0.753-0.808), and comparable performance was observed for TBC1D10C alone. Enrichment analyses associated higher TBC1D10C expression with immune pathways, including Th1/Th2 differentiation, IL-17 signaling, and NK cell-mediated cytotoxicity. qPCR confirmed significant upregulation of TBC1D10C in peripheral blood from children with obesity. Across independent cohorts and platforms, TBC1D10C was identified as a reproducible NK- and T-cell-associated biomarker for childhood obesity, and immune dysregulation relevant to obesity pathophysiology may be reflected by its expression. Therefore, we propose TBC1D10C as a promising diagnostic biomarker and highlight its potential role in the immunopathology of childhood obesity. CI - (c) King Abdulaziz City for Science and Technology 2026. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. FAU - Huang, Houyan AU - Huang H AD - Department of Pediatric Chinese Medicine, Anhui Provincial Children's Hospital, 39 Wangjiang East Road, Hefei, 230011 Anhui China. ROR: https://ror.org/04je70584. GRID: grid.489986.2. ISNI: 0000 0004 6473 1769 FAU - Huang, Yang AU - Huang Y AUID- ORCID: 0009-0002-1684-1181 AD - Heilongjiang University of Chinese Medicine, 24 Heping Road, Harbin, 150040 Heilongjiang China. ROR: https://ror.org/05x1ptx12. GRID: grid.412068.9. ISNI: 0000 0004 1759 8782 FAU - Zhang, Yuping AU - Zhang Y AD - Department of Pediatrics, Wuhu Traditional Chinese Medicine Hospital Affiliated with Anhui College of Traditional Chinese Medicine, 430 Jiuhua South Road, Wuhu, 241000 Anhui China. ROR: https://ror.org/035cyhw15. GRID: grid.440665.5. ISNI: 0000 0004 1757 641X FAU - Jiang, Ye AU - Jiang Y AD - Department of Pediatric Chinese Medicine, Anhui Provincial Children's Hospital, 39 Wangjiang East Road, Hefei, 230011 Anhui China. ROR: https://ror.org/04je70584. GRID: grid.489986.2. ISNI: 0000 0004 6473 1769 FAU - Shi, Pei AU - Shi P AD - Department of Ultrasound, Anhui Provincial Children's Hospital, 39 Wangjiang East Road, Hefei, 230011 Anhui China. ROR: https://ror.org/04je70584. GRID: grid.489986.2. ISNI: 0000 0004 6473 1769 FAU - Wang, Yingying AU - Wang Y AD - Department of Pediatric Chinese Medicine, Anhui Provincial Children's Hospital, 39 Wangjiang East Road, Hefei, 230011 Anhui China. ROR: https://ror.org/04je70584. GRID: grid.489986.2. ISNI: 0000 0004 6473 1769 FAU - Liu, Sujuan AU - Liu S AD - Department of Pediatric Chinese Medicine, Anhui Provincial Children's Hospital, 39 Wangjiang East Road, Hefei, 230011 Anhui China. ROR: https://ror.org/04je70584. GRID: grid.489986.2. ISNI: 0000 0004 6473 1769 FAU - Xu, Ping AU - Xu P AD - Department of Pediatric Chinese Medicine, Anhui Provincial Children's Hospital, 39 Wangjiang East Road, Hefei, 230011 Anhui China. ROR: https://ror.org/04je70584. GRID: grid.489986.2. ISNI: 0000 0004 6473 1769 FAU - Wang, Juanjuan AU - Wang J AD - Department of Endocrinology, Anhui Provincial Children's Hospital, 39 Wangjiang East Road, Hefei, 230011 Anhui China. ROR: https://ror.org/04je70584. GRID: grid.489986.2. ISNI: 0000 0004 6473 1769 FAU - Zhou, Taocheng AU - Zhou T AD - Department of Pediatric Chinese Medicine, Anhui Provincial Children's Hospital, 39 Wangjiang East Road, Hefei, 230011 Anhui China. ROR: https://ror.org/04je70584. GRID: grid.489986.2. ISNI: 0000 0004 6473 1769 LA - eng PT - Journal Article DEP - 20260415 PL - Germany TA - 3 Biotech JT - 3 Biotech JID - 101565857 PMC - PMC13083731 OTO - NOTNLM OT - Childhood obesity OT - Diagnostic biomarker OT - Multi-omics OT - NK-T cells OT - Single-cell RNA sequencing OT - TBC1D10C COIS- Conflict of interestNo conflicts of interest were declared. EDAT- 2026/04/20 13:10 MHDA- 2026/04/20 13:11 PMCR- 2027/05/01 CRDT- 2026/04/20 07:26 PHST- 2025/12/19 00:00 [received] PHST- 2026/04/05 00:00 [accepted] PHST- 2026/04/20 13:11 [medline] PHST- 2026/04/20 13:10 [pubmed] PHST- 2026/04/20 07:26 [entrez] PHST- 2027/05/01 00:00 [pmc-release] AID - 4818 [pii] AID - 10.1007/s13205-026-04818-8 [doi] PST - ppublish SO - 3 Biotech. 2026 May;16(5):165. doi: 10.1007/s13205-026-04818-8. Epub 2026 Apr 15. PMID- 42003163 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260827 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 2 DP - 2026 Apr TI - Providing Choice: Exploring Maternal Perceptions of Infant Feeding When Supplementation Is Required. PG - e70164 LID - 10.1111/mcn.70164 [doi] LID - e70164 AB - Exclusive breastfeeding is recommended for the first 6 months of life. However, many full-term infants require supplementation in the first few days of life, with formula often being the only supplementation option provided. With increased awareness and availability, donor human milk is becoming a viable alternative for supplementation in full-term infants. This study aimed to understand how having a choice to supplement infants with donor human milk rather than formula informed maternal experiences with infant feeding. Using a qualitative descriptive design, we conducted 15 semi-structured interviews with mothers who chose to supplement their infant with donor human milk. The semi-structured interview guide was co-developed with milk banking associations to elicit feeding goals, perceptions of donor human milk, infant feeding experiences in the first weeks of life and perceived well-being, health, and feelings around supplementation. Interviews were analyzed using reflexive thematic analysis. Of the 15 participants, over half delivered via cesarean section (n = 8), the majority were primiparous and had no previous breastfeeding experience (n = 12) and most wanted to exclusively breastfeed their infant (n = 11). Four overarching themes were identified: (1) feeding experience, (2) supplementation, (3) maternal well-being, and (4) feasibility. Choosing donor human milk positively impacted participant mental health, helped relieve stress from the pressure to breastfeed, and provided peace of mind. Donor human milk may provide a feasible intervention that may help to mitigate maternal distress by providing a supplement that is more to similar breastmilk, while breastfeeding is being established. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Ezeigbo, Oby AU - Ezeigbo O AD - Faculty of Nursing, University of Calgary, Calgary, Alberta, Canada. FAU - Festival, Jannette AU - Festival J AD - NorthernStar Mother's Milk Bank, Calgary, Alberta, Canada. FAU - Ou, Christine AU - Ou C AUID- ORCID: 0000-0003-3479-7591 AD - Faculty of Health, University of Victoria, Victoria, British Columbia, Canada. FAU - Dion, Jennifer AU - Dion J AD - Faculty of Nursing, University of Calgary, Calgary, Alberta, Canada. AD - Children's Hospital of Eastern Ontario Research Institute (CHEO RI), Ottawa, Ontario, Canada. FAU - Rusi, Heather Christine AU - Rusi HC AUID- ORCID: 0009-0002-4108-6608 AD - Faculty of Nursing, University of Calgary, Calgary, Alberta, Canada. AD - Alberta Children's Hospital Research Institute (ACHRI), Calgary, Alberta, Canada. FAU - Brockway, Meredith AU - Brockway M AUID- ORCID: 0000-0002-1024-2594 AD - Faculty of Nursing, University of Calgary, Calgary, Alberta, Canada. AD - Alberta Children's Hospital Research Institute (ACHRI), Calgary, Alberta, Canada. AD - Community Health Sciences, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. LA - eng GR - 97628712/Social Sciences and Humanities Research Council/ GR - 96195293/CIHR/Canada PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Female MH - *Breast Feeding/psychology MH - *Milk, Human MH - Adult MH - *Mothers/psychology MH - Infant MH - Infant, Newborn MH - *Dietary Supplements MH - *Choice Behavior MH - Infant Formula MH - Infant Nutritional Physiological Phenomena MH - Young Adult PMC - PMC13092807 OTO - NOTNLM OT - breastfeeding OT - donor human milk OT - formula OT - full-term infants OT - maternal mental health OT - postpartum OT - supplementation COIS- Jannette Festival is the CEO of the NorthernStar Mothers Milk Bank and a former Director on the Board of Directors for the Human Milk Banking Association of North America. Meredith Brockway is a director on the Board of Directors for the NorthernStar Mothers Milk Bank and serves on the Scientific Advisory Board for the Human Milk Banking Association of North America. EDAT- 2026/04/20 06:30 MHDA- 2026/04/20 06:31 PMCR- 2026/04/19 CRDT- 2026/04/20 02:23 PHST- 2026/01/05 00:00 [revised] PHST- 2025/07/12 00:00 [received] PHST- 2026/01/10 00:00 [accepted] PHST- 2026/04/20 06:31 [medline] PHST- 2026/04/20 06:30 [pubmed] PHST- 2026/04/20 02:23 [entrez] PHST- 2026/04/19 00:00 [pmc-release] AID - MCN70164 [pii] AID - 10.1111/mcn.70164 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Apr;22(2):e70164. doi: 10.1111/mcn.70164. PMID- 42002018 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260806 IS - 1879-1891 (Electronic) IS - 0002-9394 (Linking) VI - 288 DP - 2026 Aug TI - Validation of the "FIRST-ROP" Algorithm at a Neonatal Intensive Care Unit Tertiary Center over Three Decades. PG - 105-111 LID - S0002-9394(26)00205-9 [pii] LID - 10.1016/j.ajo.2026.04.010 [doi] AB - PURPOSE: To validate the FIRST-ROP algorithm in a medium-risk cohort of infants undergoing screening for retinopathy of prematurity (ROP). DESIGN: Retrospective diagnostic comparison. METHODS: Infants who did not meet criteria for microprematurity or nanoprematurity (gestational age >/= 27 weeks and birth weight >/= 800 g) were included. Outcomes assessed included rates of ROP diagnosis and treatment-warranted ROP (TW-ROP), as well as postmenstrual age (PMA) at first diagnosis and initiation of treatment. Paired binary detection outcomes between traditional ROP screening strategies and the FIRST-ROP algorithm, which defers screening until 34 weeks PMA, were compared using the McNemar test. RESULTS: Among 8564 infants screened, 3641 (36%) met inclusion criteria, of whom 604 (17%) developed ROP. Median PMA at first ROP diagnosis was 35.1 weeks (interquartile range [IQR], 34.0-36.6 weeks; range, 31.3-51.4 weeks). Median PMA at stage 3 diagnosis was 35.6 weeks (IQR, 34.0-37.0 weeks; range, 32.3-47.6 weeks). Median PMA at first treatment was 40.0 weeks (IQR, 37.1-41.4 weeks; range, 34.3-44.4 weeks). Fifteen infants (2%) required treatment, of whom 10 (67%) had type 1 ROP. Initiating screening at 34 weeks PMA significantly reduced examinations compared with standard screening (P < .001), corresponding to an estimated 17% fewer visits per patient. No cases of TW-ROP would have been missed under the FIRST-ROP strategy (95% CI, 99.3%-100%). CONCLUSIONS: Over 3 decades, no infants in this medium-risk cohort required treatment before 34 weeks PMA. These findings validate the FIRST-ROP algorithm and support safe deferral of the initial ROP examination to 34 weeks PMA, reducing screening burden while maintaining sensitivity for TW-ROP. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Malek, Davina A AU - Malek DA AD - From the Bascom Palmer Eye Institute (D.A.M., C.N., N.A., J.S.L., N.A.Y., H.U.H., A.M.B.), University of Miami, Miami, Florida, USA. FAU - Altamirano, Francisco AU - Altamirano F AD - Department of Ophthalmology (F.A., C.C., N.A.P.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. FAU - Chaaya, Celine AU - Chaaya C AD - Department of Ophthalmology (F.A., C.C., N.A.P.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Ophthalmology (C.C., N.A.P.), Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA. FAU - Negron, Catherin AU - Negron C AD - From the Bascom Palmer Eye Institute (D.A.M., C.N., N.A., J.S.L., N.A.Y., H.U.H., A.M.B.), University of Miami, Miami, Florida, USA. FAU - Arias, Nancy AU - Arias N AD - From the Bascom Palmer Eye Institute (D.A.M., C.N., N.A., J.S.L., N.A.Y., H.U.H., A.M.B.), University of Miami, Miami, Florida, USA. FAU - Lockward, Joaquin Sosa AU - Lockward JS AD - From the Bascom Palmer Eye Institute (D.A.M., C.N., N.A., J.S.L., N.A.Y., H.U.H., A.M.B.), University of Miami, Miami, Florida, USA. FAU - Fan, Kenneth C AU - Fan KC AD - Retina Consultants of Texas (K.C.F., H.A.K.), Houston, Texas, USA. FAU - Al-Khersan, Hasenin AU - Al-Khersan H AD - Retina Consultants of Texas (K.C.F., H.A.K.), Houston, Texas, USA. FAU - Yannuzzi, Nicolas A AU - Yannuzzi NA AD - From the Bascom Palmer Eye Institute (D.A.M., C.N., N.A., J.S.L., N.A.Y., H.U.H., A.M.B.), University of Miami, Miami, Florida, USA. FAU - Hua, Hong-Uyen AU - Hua HU AD - From the Bascom Palmer Eye Institute (D.A.M., C.N., N.A., J.S.L., N.A.Y., H.U.H., A.M.B.), University of Miami, Miami, Florida, USA. FAU - Berrocal, Audina M AU - Berrocal AM AD - From the Bascom Palmer Eye Institute (D.A.M., C.N., N.A., J.S.L., N.A.Y., H.U.H., A.M.B.), University of Miami, Miami, Florida, USA. Electronic address: aberrocal@med.miami.edu. FAU - Patel, Nimesh A AU - Patel NA AD - Department of Ophthalmology (F.A., C.C., N.A.P.), Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Ophthalmology (C.C., N.A.P.), Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA. Electronic address: nimesh_patel2@meei.harvard.edu. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20260417 PL - United States TA - Am J Ophthalmol JT - American journal of ophthalmology JID - 0370500 SB - IM MH - Humans MH - *Retinopathy of Prematurity/diagnosis MH - *Algorithms MH - Infant, Newborn MH - Retrospective Studies MH - Female MH - *Intensive Care Units, Neonatal/statistics & numerical data MH - Gestational Age MH - Male MH - *Neonatal Screening/methods MH - *Tertiary Care Centers/statistics & numerical data MH - Birth Weight EDAT- 2026/04/20 13:10 MHDA- 2026/07/08 12:57 CRDT- 2026/04/19 19:21 PHST- 2026/02/05 00:00 [received] PHST- 2026/04/10 00:00 [revised] PHST- 2026/04/10 00:00 [accepted] PHST- 2026/07/08 12:57 [medline] PHST- 2026/04/20 13:10 [pubmed] PHST- 2026/04/19 19:21 [entrez] AID - S0002-9394(26)00205-9 [pii] AID - 10.1016/j.ajo.2026.04.010 [doi] PST - ppublish SO - Am J Ophthalmol. 2026 Aug;288:105-111. doi: 10.1016/j.ajo.2026.04.010. Epub 2026 Apr 17. PMID- 42001045 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Apr 18 TI - Birth-size reference charts for newborns admitted to the neonatal intensive care units. LID - 10.1186/s12887-026-06889-1 [doi] LID - 509 AB - BACKGROUND: Our original birth-size reference charts (the Olsen charts), published in 2010 (weight, length, head circumference) and 2015 (body mass index), had limitations, including manually defined exclusion criteria and the use of completed gestational weeks. This project aimed to update the charts and address those limitations. METHODS: We analyzed de-identified data from infants admitted to Pediatrix NICUs between 2010 and 2022. In contrast to prior work, newborns with mortality before discharge, multiple births, and congenital anomalies were included; only statistical outliers (defined as two times the interquartile range below the first quartile or above the third quartile) were excluded. Gestational age was recorded in days, and penalized b-splines were used as curve smoothers. Birth weight, length, head circumference, and BMI models were developed using a randomly selected subset and validated by the remaining data. Proportions of SGA and LGA infants were compared to the 2010 Olsen and 2013 Fenton charts. RESULTS: One million one hundred fifty-two thousand seven hundred twenty infants born between 22 and 41 weeks of gestation were included. No overfitting bias was observed in the new charts. These charts more accurately identified the expected 10% of newborns as SGA/LGA compared to existing charts. CONCLUSIONS: The use of refined methods in new charts improved birth size referencing for NICU infants. FAU - Chou, Fu-Sheng AU - Chou FS AD - Southern California Permanente Medical Group, Pasadena, CA, USA. Fu-Sheng.X.Chou@kp.org. AD - Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA. Fu-Sheng.X.Chou@kp.org. AD - Department of Clinical Science, Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA, USA. Fu-Sheng.X.Chou@kp.org. AD - Department of Neonatology, Kaiser Permanente Riverside Medical Center, 10800 Magnolia Ave., Riverside, CA, 92505, USA. Fu-Sheng.X.Chou@kp.org. FAU - Yeh, Hung-Wen AU - Yeh HW AD - Division of Health Services and Outcomes Research, Children's Mercy Research Institute, Kansas City, MO, USA. AD - Department of Pediatrics, School of Medicine, University of Missouri-Kansas City, Kansas City, MO, USA. FAU - Hsueh, Crystal AU - Hsueh C AD - Psychobiology Program, University of California, Los Angeles, CA, USA. FAU - Olsen, Irene E AU - Olsen IE AD - Department of Nutrition Sciences, College of Nursing and Health Professions, Drexel University, Philadelphia, PA, USA. FAU - Tolia, Veeral N AU - Tolia VN AD - Center for Research, Education, Quality and Safety, Pediatrix Inc., Sunrise, FL, USA. FAU - Clark, Reese H AU - Clark RH AD - Department of Pediatrics, Duke University School of Medicine, Durham, NC, USA. LA - eng PT - Journal Article DEP - 20260418 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Infant, Newborn MH - *Intensive Care Units, Neonatal MH - *Birth Weight MH - Reference Values MH - Infant, Large for Gestational Age MH - *Growth Charts MH - Female MH - Gestational Age MH - Infant, Small for Gestational Age MH - Male MH - Body Mass Index PMC - PMC13224568 OTO - NOTNLM OT - Anthropometric measures OT - Growth charts OT - Neonatal intensive care units COIS- Declarations. Ethics approval and consent to participate: This data-only study with a deidentified dataset was deemed non-human research by the Kaiser Permanente Southern California Institutional Review Board ( https://kpscnursingresearch.org/kpsc-institutional-review-board-irb/ ). As such, informed consent to participate was not required, including from the parents or legal guardians of any participant under the age of 16. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/19 13:11 MHDA- 2026/06/28 06:36 PMCR- 2026/04/18 CRDT- 2026/04/18 23:24 PHST- 2025/10/30 00:00 [received] PHST- 2026/04/10 00:00 [accepted] PHST- 2026/06/28 06:36 [medline] PHST- 2026/04/19 13:11 [pubmed] PHST- 2026/04/18 23:24 [entrez] PHST- 2026/04/18 00:00 [pmc-release] AID - 10.1186/s12887-026-06889-1 [pii] AID - 6889 [pii] AID - 10.1186/s12887-026-06889-1 [doi] PST - epublish SO - BMC Pediatr. 2026 Apr 18;26(1):509. doi: 10.1186/s12887-026-06889-1. PMID- 42000095 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260613 IS - 1873-1597 (Electronic) IS - 1572-1000 (Linking) VI - 59 DP - 2026 Jun TI - Association between systemic inflammation and obesity-myopia comorbidity in adolescents: A cross-sectional analysis. PG - 105483 LID - S1572-1000(26)00150-X [pii] LID - 10.1016/j.pdpdt.2026.105483 [doi] AB - OBJECTIVE: This study aimed to investigate the association between systemic inflammation and the comorbidity of obesity and myopia among adolescents, focusing on the Systemic Immune-Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) as markers of inflammation. METHODS: This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (NHANES) spanning 1999-2008. The associations between SII and SIRI and obesity-myopia comorbidity were evaluated using multivariable logistic regression, restricted cubic spline (RCS) modeling, and subgroup analyses. RESULTS: A total of 8043 adolescents were included in this study. Multivariable logistic regression analysis indicated a significant positive association between both SII and SIRI, analyzed as continuous and quartile-based variables, and the likelihood of obesity-myopia comorbidity (p < 0.05). A dose-response relationship was observed, with the highest quartile of SII (Q4) associated with an odds ratio (OR) of 2.78 and the highest quartile of SIRI associated with an OR of 2.12. RCS analysis indicated significant nonlinear associations (SII: p(nonlinear) < 0.001; SIRI: p(nonlinear) = 0.001), suggesting that inflammation is positively associated with myopia after exceeding a critical threshold. Subgroup analysis demonstrated that these associations were statistically significant among adolescents with mild to moderate myopia, but not among those with high myopia. However, due to the non‑significant interaction term, these subgroup results should be considered exploratory analyses of this study. CONCLUSIONS: The findings of this study indicate a nonlinear dose-dependent association between systemic inflammatory markers (SII and SIRI) and the comorbidity of obesity and myopia in adolescents. This association was particularly evident in adolescents with mild to moderate myopia. However, due to the cross‑sectional design and the exploratory nature of the subgroup analyses, causality cannot be established, and further research is needed for validation. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Li, Minmin AU - Li M AD - The Second Clinical Medical College, Jinan University, Shenzhen, 518040 Guangdong Province, China. FAU - Deng, Hongwei AU - Deng H AD - Department of Strabismus and Pediatric Ophthalmology, Shenzhen Eye Hospital, Shenzhen Eye Center, Southern Medical University, Shenzhen, 518040 Guangdong Province, China. Electronic address: denghongwei@sz-eyes.com. FAU - Chen, Dingyan AU - Chen D AD - Shenzhen Center for Disease Control and Prevention, Shenzhen, 518055 Guangdong Province, China. FAU - Tao, Zhengyang AU - Tao Z AD - Department of Strabismus and Pediatric Ophthalmology, Shenzhen Eye Hospital, Shenzhen Eye Center, Southern Medical University, Shenzhen, 518040 Guangdong Province, China. FAU - Xu, Zhixing AU - Xu Z AD - The Second Clinical Medical College, Jinan University, Shenzhen, 518040 Guangdong Province, China. FAU - Hu, Guorui AU - Hu G AD - The Second Clinical Medical College, Jinan University, Shenzhen, 518040 Guangdong Province, China. FAU - Lv, Zongyue AU - Lv Z AD - Department of Strabismus and Pediatric Ophthalmology, Shenzhen Eye Hospital, Shenzhen Eye Center, Southern Medical University, Shenzhen, 518040 Guangdong Province, China. LA - eng PT - Journal Article DEP - 20260416 PL - Netherlands TA - Photodiagnosis Photodyn Ther JT - Photodiagnosis and photodynamic therapy JID - 101226123 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Adolescent MH - Male MH - *Inflammation/epidemiology MH - Comorbidity MH - *Myopia/epidemiology/immunology MH - *Obesity/epidemiology MH - Nutrition Surveys OTO - NOTNLM OT - Cross-sectional study OT - Inflammation OT - Myopia OT - Nonlinear association OT - Obesity OT - Obesity-myopia comorbidity OT - Systemic Immune-inflammation Index (SII), Systemic inflammatory response index (SIRI) COIS- Declaration of competing interest The authors declare that they have no competing interests. EDAT- 2026/04/19 13:11 MHDA- 2026/06/15 11:32 CRDT- 2026/04/18 19:16 PHST- 2026/03/02 00:00 [received] PHST- 2026/04/10 00:00 [revised] PHST- 2026/04/15 00:00 [accepted] PHST- 2026/06/15 11:32 [medline] PHST- 2026/04/19 13:11 [pubmed] PHST- 2026/04/18 19:16 [entrez] AID - S1572-1000(26)00150-X [pii] AID - 10.1016/j.pdpdt.2026.105483 [doi] PST - ppublish SO - Photodiagnosis Photodyn Ther. 2026 Jun;59:105483. doi: 10.1016/j.pdpdt.2026.105483. Epub 2026 Apr 16. PMID- 42000045 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260726 IS - 1541-6100 (Electronic) IS - 0022-3166 (Print) IS - 0022-3166 (Linking) VI - 156 IP - 6 DP - 2026 Jun TI - Prenatal and Postnatal Maternal Psychological Distress and the Metabolomic Profile of Human Milk. PG - 101531 LID - S0022-3166(26)00180-X [pii] LID - 10.1016/j.tjnut.2026.101531 [doi] LID - 101531 AB - BACKGROUND: Human milk is the gold standard of infant nutrition, providing nutrients and bioactive metabolites that shape infant immune, cognitive, and metabolic development. Maternal psychological distress, including stress, anxiety, and depression, is prevalent during the perinatal period and may influence milk composition. Emerging evidence suggests that these alter metabolite classes, with potential long-term consequences for infant health. OBJECTIVES: This study aims to identify whether maternal stress, depressive, and anxiety symptoms are associated with differential metabolomic signatures in human milk from 2.5 to 24 mo postpartum. METHODS: Human milk samples were collected longitudinally at multiple postpartum time points from 424 mothers in the FinnBrain Birth Cohort study, yielding 718 samples. Human milk metabolite concentrations were quantified using (1)H nuclear magnetic resonance-based metabolomics. Maternal depressive, anxiety, and stress symptoms were assessed using validated self-report scales prenatally and postnatally. Simple linear regression and linear mixed models examined associations between maternal symptom scores and human milk metabolite concentrations across lactation (false discovery rate <0.05). RESULTS: Human milk oligosaccharides such as Lacto-N-tetraose (LNT), lacto-N-fucopentaose I (LNFP I), and lacto-N-difucohexaose I/II (LNDFH I/II) showed negative associations with depressive and stress symptoms, whereas 3'-fucosyllactose (3'FL), 3'-sialyllactose (3'SL), and lacto-N-neotetraose (LNnT) were positively linked, particularly with prenatal symptoms.. Among amino acids, threonine concentrations declined with higher maternal symptom scores, whereas glutamate, glutamine, and taurine exhibited time-dependent associations across lactation. Succinate and hippurate showed positive associations with prenatal maternal symptom scores that shifted to negative associations later in lactation, whereas lactose and caprylate were negatively associated with postnatal symptoms. CONCLUSIONS: Both prenatal and postnatal maternal distress are associated with human milk metabolites. Human milk may buffer infants from some effects of maternal psychological distress because increases in key metabolites suggest potential compensatory roles in immune modulation and healthy gut microbiota. However, reductions in metabolites with established prebiotic and immune regulatory functions reinforce the importance of interventions that support maternal mental health during the perinatal period. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Ryan, Niamh AU - Ryan N AD - School of Nursing and Midwifery, University College Cork, Cork, Ireland. Electronic address: 122117696@umail.ucc.ie. FAU - Sundekilde, Ulrik Kramer AU - Sundekilde UK AD - Department of Food Science, Aarhus University, Aarhus, Denmark. FAU - Dickens, Alex M AU - Dickens AM AD - Turku Bioscience Centre, University of Turku, Turku, Finland; Department of Chemistry, University of Turku, Turku, Finland. FAU - Kalant, Henna-Maria AU - Kalant HM AD - FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland. FAU - Leahy-Warren, Patricia AU - Leahy-Warren P AD - School of Nursing and Midwifery, University College Cork, Cork, Ireland. FAU - Philpott, Lloyd Frank AU - Philpott LF AD - School of Nursing and Midwifery, University College Cork, Cork, Ireland. FAU - Mulcahy, Helen AU - Mulcahy H AD - School of Nursing and Midwifery, University College Cork, Cork, Ireland. FAU - Lamichhane, Santosh AU - Lamichhane S AD - Turku Bioscience Centre, University of Turku, Turku, Finland; Research Center for Infections and Immunity, Institute of Biomedicine, University of Turku, Turku, Finland. FAU - Isokaanta, Heidi AU - Isokaanta H AD - Turku Bioscience Centre, University of Turku, Turku, Finland; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland; Research Center for Infections and Immunity, Institute of Biomedicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. FAU - Perasto, Laura AU - Perasto L AD - FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. FAU - Tarro, Saija AU - Tarro S AD - FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. FAU - Karlsson, Hasse AU - Karlsson H AD - FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Department of Psychiatry, University of Turku and Turku University Hospital, Turku, Finland. FAU - Karlsson, Linnea AU - Karlsson L AD - Department of Chemistry, University of Turku, Turku, Finland; FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland; Department of Pediatrics and Adolescent Medicine, Turku University Hospital and University of Turku, Turku, Finland. FAU - O'Mahony, Siobhain M AU - O'Mahony SM AD - Department of Anatomy and Neuroscience, University College Cork, Cork, Ireland; APC Microbiome Ireland, University College Cork, Cork, Ireland. FAU - Aatsinki, Anna-Katariina AU - Aatsinki AK AD - FinnBrain Birth Cohort Study, Turku Brain and Mind Center, Department of Clinical Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. LA - eng PT - Journal Article DEP - 20260416 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 RN - 0 (Oligosaccharides) SB - IM MH - Humans MH - *Milk, Human/chemistry/metabolism MH - Female MH - Pregnancy MH - Adult MH - *Stress, Psychological/metabolism MH - Longitudinal Studies MH - Metabolomics MH - *Psychological Distress MH - Oligosaccharides/metabolism MH - Postpartum Period MH - Depression/metabolism MH - Mothers/psychology MH - Lactation MH - Infant PMC - PMC13279302 OTO - NOTNLM OT - anxiety OT - depression OT - human milk composition OT - maternal stress OT - metabolome COIS- Conflict of interest H-MK is currently employed by International Foods and Flavors Inc. EDAT- 2026/04/19 13:11 MHDA- 2026/06/13 06:39 PMCR- 2027/04/16 CRDT- 2026/04/18 19:15 PHST- 2025/10/01 00:00 [received] PHST- 2026/03/30 00:00 [revised] PHST- 2026/04/07 00:00 [accepted] PHST- 2026/06/13 06:39 [medline] PHST- 2026/04/19 13:11 [pubmed] PHST- 2026/04/18 19:15 [entrez] PHST- 2027/04/16 00:00 [pmc-release] AID - S0022-3166(26)00180-X [pii] AID - 101531 [pii] AID - 10.1016/j.tjnut.2026.101531 [doi] PST - ppublish SO - J Nutr. 2026 Jun;156(6):101531. doi: 10.1016/j.tjnut.2026.101531. Epub 2026 Apr 16. PMID- 41999989 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260803 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 224 DP - 2026 Sep 1 TI - Evaluation of parental reports as a proxy for their children's food preferences. PG - 108561 LID - S0195-6663(26)00123-6 [pii] LID - 10.1016/j.appet.2026.108561 [doi] AB - As childhood obesity rates rise, research on children's food preferences gains importance. However, studies on these preferences have predominantly relied on parental reports. Research assumes that parents are accurate informants, given their role as food providers. However, excluding children introduces limitations, as parents may misinterpret or overestimate their children's food preferences. Conversely, children's self-reports are hampered by cognitive and language challenges. Leveraging an online survey, this study examines whether children's reports of their food preferences align with those reported by their parents. A diverse range of statistical methods was implemented to examine agreement in 510 parent-child dyads. These included Spearman's rho, intra-class correlation coefficients, Multitrait-Multimethod analysis complemented with a confirmatory factor analysis (MTMM-CFA), and linear regressions. There were strong correlations across food-related constructs, indicating robust consensus (r >/= 0.60). MTMM-CFA model comparison analyses also demonstrated strong convergent (r >/= 0.61) and discriminant validity (r 0.05). In the experimental group, breastfeeding satisfaction was significantly higher (very satisfied: 68.9%; control: 22.5%) (p < 0.001). There was a statistically significant difference (p < 0.001) between the experimental group's mean IBFAT scores of 9.48 +/- 1.85 and the control group's 5.95 +/- 2.09. The effect size (Cohen's d = 1.78) was determined to be large. CONCLUSION: During the first breastfeeding session following a cesarean section, the modified football hold was found to be an effective method for increasing maternal satisfaction and promoting breastfeeding success. The effectiveness of breastfeeding and mother-baby bonding is thought to be enhanced by midwives' use of it in clinical settings. Nevertheless, further research using larger sample sizes and in various centers is required to validate the efficacy of this method. FAU - Oguz, Benay AU - Oguz B AD - Department of Midwifery, Faculty of Health Sciences, Balikesir University, Balikesir, Turkiye. FAU - Bolsoy, Nursen AU - Bolsoy N AD - Department of Midwifery, Faculty of Health Sciences, Manisa Celal Bayar University, Manisa, Turkiye. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260121 PL - United States TA - Breastfeed Med JT - Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine JID - 101260777 SB - IM MH - Humans MH - Female MH - *Breast Feeding/methods/psychology MH - Pilot Projects MH - *Cesarean Section MH - Adult MH - Infant, Newborn MH - Pregnancy MH - *Midwifery/methods MH - *Mothers/psychology MH - Turkey MH - Postpartum Period MH - Patient Satisfaction MH - *Postnatal Care/methods OTO - NOTNLM OT - breastfeeding positions OT - cesarean section OT - midwife support EDAT- 2026/04/17 13:25 MHDA- 2026/04/17 13:26 CRDT- 2026/04/17 07:34 PHST- 2026/04/17 13:26 [medline] PHST- 2026/04/17 13:25 [pubmed] PHST- 2026/04/17 07:34 [entrez] AID - 10.1177/15568253261415604 [doi] PST - ppublish SO - Breastfeed Med. 2026 Apr;21(4):250-257. doi: 10.1177/15568253261415604. Epub 2026 Jan 21. PMID- 41995022 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 1118-4841 (Print) IS - 1118-4841 (Linking) VI - 30 IP - 7s DP - 2026 Apr 17 TI - Informing reproductive, maternal, neonatal, child, and adolescent health and nutrition priority-setting and financing in Guinea: Findings from a national investment case study. PG - 62-72 LID - (Afr J Reprod Health 2026; 30 [7s]: 62-72) [pii] LID - 10.29063/ajrh2026/v30i7s.6 [doi] AB - Guinea faces high maternal and child mortality, low coverage of essential reproductive, maternal, neonatal, child and adolescent health and nutrition (RMNCAH+N) services, and major financing constraints. This study developed a national investment case for 2026-2030 to estimate the costs, health gains, economic returns, and fiscal feasibility of scaling up priority interventions. The analysis integrated situational, budget, costing, cost-benefit, cost of inaction, and fiscal space assessments, and modelled four scenarios. Despite broad service availability, major gaps persist in quality, continuity, and effective coverage. Health expenditure reached USD 776 million in 2022 but remained heavily reliant on household spending. Scale-up would require an additional USD 200-447 million above the baseline, could avert about 334,000 disability-adjusted life years (DALYs) by 2030, and would generate benefit-cost ratios ranging from 6.7 by 2030 to more than 110 by 2050. By contrast, the cost of inaction would reach USD 1.6-2.8 billion by 2030. These findings indicate that scaling high-impact interventions is economically justified and fiscally feasible. CI - African Journal of Reproductive Health (c) 2026. FAU - Bilivogui, Jim P AU - Bilivogui JP AD - United Nations Population Fund, Guinea Country Office, Guinea. FAU - Kekana, Loveness AU - Kekana L AD - Genesis Analytics, South Africa FAU - Toure, Almamy A AU - Toure AA AD - National Institute of Public Health, Guinea AD - Gamal Abdel Nasser University, Guinea FAU - Diallo, Ndiouga AU - Diallo N AD - United Nations Population Fund, Guinea Country Office, Guinea. FAU - Torres-Rueda, Sergio AU - Torres-Rueda S AD - Genesis Analytics, South Africa AD - London School of Hygiene & Tropical Medicine, United Kingdom FAU - Kaba, Dieney F AU - Kaba DF AD - Ministere de la Sante et de l'Hygiene Publique, Guinea LA - eng PT - Journal Article PL - Nigeria TA - Afr J Reprod Health JT - African journal of reproductive health JID - 9712263 SB - IM MH - Humans MH - Female MH - Cost-Benefit Analysis MH - Guinea MH - Adolescent MH - *Health Priorities/economics MH - Infant, Newborn MH - Child MH - Pregnancy MH - Infant MH - Health Expenditures MH - Adolescent Health/economics MH - Child Health MH - *Maternal-Child Health Services/economics MH - *Maternal Health Services/economics MH - Maternal Health OTO - NOTNLM OT - Guinea OT - RMNCAH+N OT - fiscal space OT - investment case OT - maternal and child health COIS- The Authors declared no conflict of interest EDAT- 2026/04/17 13:26 MHDA- 2026/04/17 13:27 CRDT- 2026/04/17 07:21 PHST- 2026/04/17 13:27 [medline] PHST- 2026/04/17 13:26 [pubmed] PHST- 2026/04/17 07:21 [entrez] AID - (Afr J Reprod Health 2026; 30 [7s]: 62-72) [pii] AID - 10.29063/ajrh2026/v30i7s.6 [doi] PST - ppublish SO - Afr J Reprod Health. 2026 Apr 17;30(7s):62-72. doi: 10.29063/ajrh2026/v30i7s.6. PMID- 41994940 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1365-2214 (Electronic) IS - 0305-1862 (Print) IS - 0305-1862 (Linking) VI - 52 IP - 3 DP - 2026 May TI - Exploring Health Care Providers, Families and Educators' Perceptions of an Online Self-Paced F-Words for Child Development Foundations Course. PG - e70277 LID - 10.1111/cch.70277 [doi] LID - e70277 AB - BACKGROUND: The F-words for Child Development (Functioning, Family, Fitness, Fun, Friendships and Future) offer a holistic, strengths-based and family-centred approach to child development, rooted in the World Health Organization's International Classification of Functioning, Disability and Health. Interest in the F-words has grown significantly among families, health care providers, educators and researchers, creating the need for accessible and scalable training to support dissemination and implementation efforts. METHODS: A self-paced online F-words Foundations Course was co-developed by families, health care providers, educators and researchers. The course consists of five 1-h modules covering the F-words approach, personal stories, goal-setting and practical strategies for integrating the F-words into daily life and practice. This study evaluated the acceptability, feasibility, usability and utility of the course through an online survey that included Likert-scaled and open-ended questions. Quantitative data were analysed using descriptive statistics, and qualitative data were analysed through content analysis. RESULTS: Fifty-five participants, including families, health care providers and educators from Ontario, completed an online survey assessing their experience. Findings were positive, with participants rating the course as useful in understanding the F-words (85%), accessible and easy to engage with (91%) and valuable in helping them achieve their learning goals (85%). Participants valued the multimedia components, particularly videos featuring individuals with lived experience, and appreciated the course's family-centred perspective. Suggested improvements included increasing interactivity (e.g., use of discussion boards and synchronous group sessions) and shortening the length or removing repetition in course content. CONCLUSION: The F-words Foundations Course is a free, accessible and online training tool that effectively supports increasing knowledge, awareness and use of the F-words in life and practice. Future directions include expanding course offerings for young individuals and exploring facilitated formats to enhance engagement. CI - (c) 2026 The Author(s). Child: Care, Health and Development published by John Wiley & Sons Ltd. FAU - Canlas, Kassidy AU - Canlas K AD - CanChild Centre for Childhood-Onset Disability Research, McMaster University, Hamilton, Canada. AD - School of Rehabilitation Science, McMaster University, Hamilton, Canada. FAU - Chahil, Arpit AU - Chahil A AD - CanChild Centre for Childhood-Onset Disability Research, McMaster University, Hamilton, Canada. AD - Faculty of Health Sciences, McMaster University, Hamilton, Canada. FAU - Teplicky, Rachel AU - Teplicky R AUID- ORCID: 0000-0002-8149-4756 AD - CanChild Centre for Childhood-Onset Disability Research, McMaster University, Hamilton, Canada. FAU - Wright, Marilyn AU - Wright M AUID- ORCID: 0000-0003-2931-5746 AD - CanChild Centre for Childhood-Onset Disability Research, McMaster University, Hamilton, Canada. AD - School of Rehabilitation Science, McMaster University, Hamilton, Canada. FAU - Grahovac, Danijela AU - Grahovac D AD - CanChild Centre for Childhood-Onset Disability Research, McMaster University, Hamilton, Canada. FAU - Hesketh, Kim AU - Hesketh K AD - CanChild Centre for Childhood-Onset Disability Research, McMaster University, Hamilton, Canada. AD - Children's Treatment Network, Simcoe York, Richmond Hill, Canada. FAU - Hughes, Debra AU - Hughes D AD - CanChild Centre for Childhood-Onset Disability Research, McMaster University, Hamilton, Canada. FAU - Rosenbaum, Peter AU - Rosenbaum P AUID- ORCID: 0000-0001-6751-5613 AD - CanChild Centre for Childhood-Onset Disability Research, McMaster University, Hamilton, Canada. AD - Department of Pediatrics, McMaster University, Hamilton, Canada. FAU - Cross, Andrea AU - Cross A AD - CanChild Centre for Childhood-Onset Disability Research, McMaster University, Hamilton, Canada. AD - Department of Pediatrics, McMaster University, Hamilton, Canada. LA - eng GR - Ontario Ministry of Children, Community and Social Services/ GR - 170668/CAPMC/CIHR/Canada GR - Kids Brain Health Network/ GR - Brain Canada/ PT - Journal Article PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM MH - Humans MH - Child MH - *Child Development MH - Female MH - Male MH - Curriculum MH - Internet MH - Attitude of Health Personnel MH - *Health Personnel/education/psychology MH - Ontario MH - Adult MH - *Education, Distance/methods MH - Family/psychology PMC - PMC13088218 OTO - NOTNLM OT - F-words for child development OT - ICF OT - childhood disability OT - family-centred care OT - knowledge translation OT - online learning OT - self-paced course COIS- The authors declare no conflicts of interest. EDAT- 2026/04/17 13:25 MHDA- 2026/04/17 13:26 PMCR- 2026/04/17 CRDT- 2026/04/17 06:42 PHST- 2026/03/25 00:00 [revised] PHST- 2025/05/02 00:00 [received] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/04/17 13:26 [medline] PHST- 2026/04/17 13:25 [pubmed] PHST- 2026/04/17 06:42 [entrez] PHST- 2026/04/17 00:00 [pmc-release] AID - CCH70277 [pii] AID - 10.1111/cch.70277 [doi] PST - ppublish SO - Child Care Health Dev. 2026 May;52(3):e70277. doi: 10.1111/cch.70277. PMID- 41994889 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260828 IS - 1541-0420 (Electronic) IS - 0006-341X (Print) IS - 0006-341X (Linking) VI - 82 IP - 2 DP - 2026 Apr 9 TI - Measurement error-robust causal inference via constructed instrumental variables. LID - 10.1093/biomtc/ujag057 [doi] LID - ujag057 AB - Measurement error can often be harmful when estimating causal effects. Two scenarios in which this is the case are in the estimation of (a) the average treatment effect when confounders are measured with error, and (b) the natural indirect effect when the exposure and/or confounders are measured with error. Methods adjusting for measurement error typically require external data or knowledge about the measurement error distribution. Here, we propose methodology not requiring any such information. Instead, we show that when the outcome regression is linear in the error-prone variables, consistent estimation of these causal effects can be recovered using constructed instrumental variables (IVs) under certain conditions. These variables, which are functions of only the observed data, behave like IVs for the error-prone variables. Using data from a study of the effects of prenatal exposure to heavy metals on growth and neurodevelopment in Bangladeshi mother-infant pairs, we apply our methodology to estimate (a) the effect of lead exposure on birth length while controlling for maternal protein intake, and (b) lead exposure's role in mediating the effect of maternal protein intake on birth length. Protein intake is calculated from food journal entries, and is suspected to be highly prone to measurement error. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of The International Biometric Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Miles, Caleb H AU - Miles CH AUID- ORCID: 0000-0002-9792-6699 AD - Department of Biostatistics, Columbia University, New York, NY 10032, United States. FAU - Valeri, Linda AU - Valeri L AUID- ORCID: 0000-0003-0664-1194 AD - Department of Biostatistics, Columbia University, New York, NY 10032, United States. FAU - Coull, Brent AU - Coull B AUID- ORCID: 0000-0002-1808-4156 AD - Department of Biostatistics, Harvard University, Boston, MA 02115, United States. LA - eng GR - R01 AG077518/AG/NIA NIH HHS/United States GR - P42 ES030990/ES/NIEHS NIH HHS/United States GR - P30 ES000002/ES/NIEHS NIH HHS/United States GR - P42ES030990/NIH/NIEHS/ GR - R21ES036704/NIH/NIEHS/ GR - P30ES000002/NIH/NIEHS/ GR - UL1 TR001873/TR/NCATS NIH HHS/United States PT - Journal Article PL - England TA - Biometrics JT - Biometrics JID - 0370625 RN - 2P299V784P (Lead) SB - IM MH - *Causality MH - Humans MH - Female MH - Pregnancy MH - *Models, Statistical MH - Data Interpretation, Statistical MH - Computer Simulation MH - Lead/toxicity MH - Prenatal Exposure Delayed Effects MH - Biometry/methods MH - Maternal Exposure PMC - PMC13521038 MID - NIHMS2205110 OTO - NOTNLM OT - causal inference OT - environmental health OT - instrumental variable OT - measurement error OT - mediation analysis OT - nutrition EDAT- 2026/04/17 13:25 MHDA- 2026/04/17 13:26 PMCR- 2026/08/27 CRDT- 2026/04/17 05:52 PHST- 2025/01/31 00:00 [received] PHST- 2026/01/06 00:00 [revised] PHST- 2026/02/26 00:00 [accepted] PHST- 2026/04/17 13:26 [medline] PHST- 2026/04/17 13:25 [pubmed] PHST- 2026/04/17 05:52 [entrez] PHST- 2026/08/27 00:00 [pmc-release] AID - 8657882 [pii] AID - 10.1093/biomtc/ujag057 [doi] PST - ppublish SO - Biometrics. 2026 Apr 9;82(2):ujag057. doi: 10.1093/biomtc/ujag057. PMID- 41994674 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260417 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 3 DP - 2026 Mar TI - Standardized, Individualized, or AI-Based Approach to Parenteral Nutrition in Neonatal Intensive Care Units: A Narrative Review. PG - e105328 LID - 10.7759/cureus.105328 [doi] LID - e105328 AB - Parenteral nutrition (PN) is fundamental in the management of premature infants hospitalized in neonatal intensive care units (NICUs). Traditionally, standardized PN (SPN) has been recommended for most newborns due to safety, faster initiation, and reduced risk of prescribing errors. However, individualized PN (IPN) remains necessary in cases of metabolic instability or prolonged PN. Recently, AI-based models, such as the TPN2.0 algorithm, have emerged as potential tools to enhance precision, safety, and clinical outcomes in PN by combining standardization and personalization. The aim of this review is to summarize and critically discuss current evidence regarding standardized, individualized, and AI-based approaches to PN in premature infants hospitalized in NICUs. Despite guidelines, practice varies, and the emerging evidence for AI needs critical synthesis. This narrative review is based on a focused, critical appraisal of the available literature. A nonsystematic search of PubMed/MEDLINE, Wiley Online Library, ScienceDirect, and Google Scholar was conducted to identify relevant articles. Additional sources included international clinical guidelines and consensus statements. The search focused on publications addressing standardized, individualized, and AI-supported PN in neonatal and pediatric intensive care settings. Selected studies were analyzed qualitatively with emphasis on clinical outcomes, nutritional adequacy, safety profiles, and practical implementation aspects. Due to the heterogeneity of study designs and outcomes, a formal systematic review methodology and meta-analysis were not performed. Across multiple studies, SPN has been found to provide adequate macronutrient and electrolyte intake for most NICU patients, enabling faster initiation of PN and reducing prescribing errors. SPN often resulted in improved early protein, glucose, calcium, and phosphate delivery compared with IPN, with fewer electrolyte disturbances and comparable or better growth outcomes. Evidence supporting IPN benefits has been inconsistent and limited primarily to metabolically unstable or complex cases. AI-based PN (TPN2.0) demonstrated promising results, with physicians rating its recommendations higher than standard prescriptions. In infants whose clinically prescribed PN differed most from AI recommendations, higher morbidity, including NEC, was observed compared with AI-guided formulations. The algorithm reduced formulation subjectivity, streamlined workflow, and enabled rapid, guideline-adherent PN prescription. Early evidence suggests a potential association with reduced rates of mortality, cholestasis, sepsis, and NEC with the use of AI-supported PN strategies. SPN remains the safest and most efficient first-line approach for most premature infants, ensuring rapid initiation and reducing prescription-related risks. IPN continues to be essential for selected high-risk patients with complex metabolic needs. Emerging AI-based systems such as TPN2.0 may bridge these approaches by delivering personalized yet SPN formulations, improving safety, efficiency, and potentially clinical outcomes. Further high-quality prospective trials are needed to validate these findings and support the integration of AI into routine NICU nutritional practice. CI - Copyright (c) 2026, Walendziak et al. FAU - Walendziak, Weronika AU - Walendziak W AD - Medicine, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, POL. FAU - Domosud, Karolina AU - Domosud K AD - Medicine, Military Institute of Medicine - National Research Institute, Warsaw, POL. FAU - Malczyk, Anna AU - Malczyk A AD - Medicine, Miedzyleski Specialist Hospital, Warsaw, POL. FAU - Zienkiewicz, Damian AU - Zienkiewicz D AD - Medicine, Praga Hospital of the Transfiguration of the Lord, Warsaw, POL. FAU - Makulec, Gabriela AU - Makulec G AD - Medicine, Military Institute of Medicine - National Research Institute, Warsaw, POL. FAU - Sciebura, Kacper AU - Sciebura K AD - Medicine, Military Institute of Medicine - National Research Institute, Warsaw, POL. FAU - Ostaszewska, Magdalena AU - Ostaszewska M AD - Medicine, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, POL. FAU - Mordal, Natalia AU - Mordal N AD - Medicine, Mazovian Brodno Hospital, Warsaw, POL. FAU - Wisniewska, Wiktoria AU - Wisniewska W AD - Medicine, Mazovian Brodno Hospital, Warsaw, POL. FAU - Majchrzyk, Milena AU - Majchrzyk M AD - Medicine, National Medical Institute of the Ministry of the Interior and Administration, Warsaw, POL. LA - eng PT - Journal Article PT - Review DEP - 20260316 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13082679 OTO - NOTNLM OT - artificial intelligence in medicine OT - individualized parenteral nutrition OT - intensive care OT - neonatal care OT - neonatal intensive care OT - nutrition in critical care OT - parenteral nutrition (pn) OT - preterm neonate OT - standardized parenteral nutrition OT - total parenteral nutrition (tpn) COIS- Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/04/17 13:26 MHDA- 2026/04/17 13:27 PMCR- 2026/03/16 CRDT- 2026/04/17 05:35 PHST- 2026/03/15 00:00 [accepted] PHST- 2026/04/17 13:27 [medline] PHST- 2026/04/17 13:26 [pubmed] PHST- 2026/04/17 05:35 [entrez] PHST- 2026/03/16 00:00 [pmc-release] AID - 10.7759/cureus.105328 [doi] PST - epublish SO - Cureus. 2026 Mar 16;18(3):e105328. doi: 10.7759/cureus.105328. eCollection 2026 Mar. PMID- 41994050 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260417 LR - 20260813 IS - 1664-042X (Print) IS - 1664-042X (Electronic) IS - 1664-042X (Linking) VI - 17 DP - 2026 TI - A multimodal deep learning-based model for posture asymmetry recognition and sports injury risk prediction in adolescent table tennis athletes. PG - 1800522 LID - 10.3389/fphys.2026.1800522 [doi] LID - 1800522 AB - BACKGROUND: Adolescent table tennis athletes face significant sports injury risks due to repetitive unilateral force generation patterns during the critical skeletal maturation period, yet traditional posture assessment methods lack quantitative precision and real-time monitoring capability. METHODS: This study develops a multimodal deep learning framework integrating video RGB sequences, skeletal keypoint trajectories, and kinematic parameters through cross-modal attention mechanisms, weighted graph convolutional networks, and temporal convolutional networks to automatically recognize posture asymmetry patterns and assess biomechanical injury risk levels based on expert-evaluated postural deviation criteria, representing prospective biomechanical risk stratification for screening purposes rather than longitudinally validated injury occurrence prediction. RESULTS: Comprehensive evaluation on the TTStroke-21 dataset demonstrates superior performance in both four-class posture asymmetry recognition and three-level injury risk prediction compared to baseline methods, validating the effectiveness of sport-specific architectural adaptations and multimodal data fusion strategies. The biomechanical analysis reveals quantitative relationships between technical movement patterns and asymmetry manifestations across different stroke types and age groups, confirming the critical intervention window during the 12-14-year developmental period. CONCLUSION: The proposed intelligent assessment system provides substantial practical value for training monitoring and injury prevention in youth sports, enabling coaches and sports medicine practitioners to implement data-driven personalized intervention strategies including contralateral limb strengthening programs and targeted corrective exercises before structural imbalances progress to clinical injury outcomes. CI - Copyright (c) 2026 Wang and Guo. FAU - Wang, Di AU - Wang D AD - School of Physical Education, Yantai University, Yantai, Shandong, China. FAU - Guo, Yue AU - Guo Y AD - School of Physical Education, University of Jinan, Jinan, Shandong, China. LA - eng PT - Journal Article DEP - 20260401 PL - Switzerland TA - Front Physiol JT - Frontiers in physiology JID - 101549006 PMC - PMC13079190 OTO - NOTNLM OT - adolescent athletes OT - multimodal deep learning OT - posture asymmetry OT - sports injury prediction OT - table tennis COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/17 13:26 MHDA- 2026/04/17 13:27 PMCR- 2026/04/01 CRDT- 2026/04/17 05:28 PHST- 2026/01/31 00:00 [received] PHST- 2026/03/07 00:00 [revised] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/04/17 13:27 [medline] PHST- 2026/04/17 13:26 [pubmed] PHST- 2026/04/17 05:28 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - 10.3389/fphys.2026.1800522 [doi] PST - epublish SO - Front Physiol. 2026 Apr 1;17:1800522. doi: 10.3389/fphys.2026.1800522. eCollection 2026. PMID- 41992910 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260806 IS - 1475-2700 (Electronic) IS - 0954-4224 (Linking) VI - 39 DP - 2026 Apr 17 TI - Outpatient and community-based management of malnourished infants aged under six months (infants u6m at risk of poor growth and development): a scoping review. PG - e20 LID - 10.1017/S0954422426100419 [doi] AB - Malnourished infants under six months (u6m) are a vulnerable but insufficiently prioritised group, with low levels of consolidated evidence to guide outpatient and community-based care. This study synthesised evidence on outpatient and community-based management of malnourished infants u6m, focusing on intervention strategies, outcomes, barriers, and policy implications. Following the JBI framework and PRISMA guidelines, this review included information published in English between 2007 and 2025 about the outpatient or community-based management of malnourished infants u6m or mother-infant dyads. Four databases and multiple institutional websites were searched, supplemented by grey literature. Data were extracted on various study features, interventions, and outcomes. A total of 26 studies were included, with only five published since the 2023 updated guidelines of the World Health Organization (WHO). Evidence was concentrated in studies from sub-Saharan Africa and South Asia. Several studies described outpatient care as feasible and acceptable in multiple contexts, with reported recovery rates ranging from 65% to 91%; however, methodological heterogeneity limits comparability across studies. Breastfeeding support, maternal health, and culturally adapted interventions were described as important indicators. Tools such as the MAMI clinical care pathway, MUAC, and the MAMI WAZ look-up chart were described as effective, but require further validation and contextual testing. Major barriers that were mentioned included shortages of trained staff, inconsistent protocols, and policy reluctance to scale outpatient models. Outpatient and community-based care for malnourished infants u6m aligns with recent WHO guidance on managing 'at-risk' infants. However, widespread adoption requires stronger evidence-based management or tools, integration into health systems, and national policies. Strengthening research and programmatic consensus will be essential to improve outcomes for this vulnerable population. FAU - Muktadir, Mohammad Hamid Al AU - Muktadir MHA AUID- ORCID: 0000-0002-2855-3921 AD - Department of Medicine, University of Oviedohttps://ror.org/006gksa02, Oviedo, Spain. AD - Department of Global Public Health, Karolinska Institute, Stockholm, Sweden. AD - Department of Public Health, Canadian University of Bangladesh, Dhaka, Bangladesh. FAU - Amat Camacho, Nieves AU - Amat Camacho N AD - Department of Global Public Health, Karolinska Institute, Stockholm, Sweden. FAU - Castro-Delgado, Rafael AU - Castro-Delgado R AD - Department of Medicine, University of Oviedohttps://ror.org/006gksa02, Oviedo, Spain. AD - Research Group on Prehospital Care and Disasters (GIAPREDE), Health Research Institute of the Principality of Asturiashttps://ror.org/05xzb7x97, Oviedo, Spain. AD - SAMU-Asturias, Health Service of the Principality of Asturiashttps://ror.org/00kj4ev13, Oviedo, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Scoping Review DEP - 20260417 PL - England TA - Nutr Res Rev JT - Nutrition research reviews JID - 9113797 SB - IM MH - Humans MH - Infant MH - *Infant Nutrition Disorders/therapy MH - *Ambulatory Care/methods MH - *Community Health Services MH - Breast Feeding MH - Female OTO - NOTNLM OT - child nutrition OT - community nutrition OT - epidemiology OT - infant malnutrition OT - nutrition OT - outpatient care EDAT- 2026/04/17 13:25 MHDA- 2026/05/18 12:43 CRDT- 2026/04/17 04:13 PHST- 2026/05/18 12:43 [medline] PHST- 2026/04/17 13:25 [pubmed] PHST- 2026/04/17 04:13 [entrez] AID - S0954422426100419 [pii] AID - 10.1017/S0954422426100419 [doi] PST - epublish SO - Nutr Res Rev. 2026 Apr 17;39:e20. doi: 10.1017/S0954422426100419. PMID- 41992805 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260921 IS - 2162-3279 (Electronic) VI - 16 IP - 4 DP - 2026 Apr TI - Validation and Adaptation of the Interpersonal Behaviors Questionnaire in the Spanish Sport Context: The Inclusion of Novelty and Analysis of Coach-Athlete Perspectives. PG - e71419 LID - 10.1002/brb3.71419 [doi] LID - e71419 AB - BACKGROUND/PURPOSE: The present study had a fourfold purpose: (a) to validate the interpersonal behaviors questionnaire (IBQ) and IBQ-Self, (b) to compare measurement models with and without the inclusion of the novelty construct, (c) to analyze the convergence/dissonance between coach and athlete perceptions, and (d) to examine the predictive validity of the model regarding athletes' motivation and intention to be physically active. METHODS: Participants were 2085 individuals (1587 athletes and 498 coaches). Data were analyzed using descriptive statistics, reliability analysis, confirmatory factor analysis (CFA), and structural equation modeling (SEM). RESULTS: CFA supported the structural validity of the IBQ, showing better fit indices for the hypothesized model including novelty (e.g., CFI = 0.97, TLI = 0.97, and RMSEA = 0.042). Regarding coach-athlete perceptions, rather than asymmetry, the results demonstrated a significant alignment between both perspectives. Finally, the SEM confirmed the predictive utility of the model, where satisfaction of basic psychological needs positively predicted motivation (beta = 0.43 and p < 0.001), which in turn positively predicted the intention to be physically active (beta = 0.39 and p < 0.001). CONCLUSION: The IBQ with the addition of novelty is a reliable instrument that structurally improves the original scale, demonstrating that athletes' perceptions of the coach and coaches' self-perceptions are synchronized and play a key role in predicting physical activity intentions. CI - (c) 2026 The Author(s). Brain and Behavior published by Wiley Periodicals LLC. FAU - Aguilar-Parra, Jose M AU - Aguilar-Parra JM AD - Department of Psychology, Hum-878 Research Team, Health Research Centre, University of Almeria, Almeria, Spain. FAU - Trigueros, Ruben AU - Trigueros R AD - Department of Psychology, Hum-878 Research Team, Health Research Centre, University of Almeria, Almeria, Spain. FAU - Fernandez-Ortega, Carmen AU - Fernandez-Ortega C AD - Department of Psychology, Hum-878 Research Team, Health Research Centre, University of Almeria, Almeria, Spain. FAU - Miralles-Dionis, Maria Del Mar AU - Miralles-Dionis MDM AD - Department of Psychology, Hum-878 Research Team, Health Research Centre, University of Almeria, Almeria, Spain. LA - eng PT - Journal Article PT - Validation Study PL - United States TA - Brain Behav JT - Brain and behavior JID - 101570837 SB - IM MH - Humans MH - Surveys and Questionnaires/standards MH - *Interpersonal Relations MH - Motivation MH - Female MH - *Athletes/psychology MH - *Sports/psychology MH - Male MH - Spain MH - Reproducibility of Results MH - Adult MH - Young Adult MH - Intention MH - *Psychometrics/instrumentation/standards MH - Adolescent PMC - PMC13087503 OTO - NOTNLM OT - basic psychological needs OT - interpersonal behavior OT - motivation OT - physical activity COIS- The authors declare no conflicts of interest. EDAT- 2026/04/17 13:25 MHDA- 2026/04/17 13:26 PMCR- 2026/04/16 CRDT- 2026/04/17 03:03 PHST- 2026/03/27 00:00 [revised] PHST- 2024/05/15 00:00 [received] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/04/17 13:26 [medline] PHST- 2026/04/17 13:25 [pubmed] PHST- 2026/04/17 03:03 [entrez] PHST- 2026/04/16 00:00 [pmc-release] AID - BRB371419 [pii] AID - 10.1002/brb3.71419 [doi] PST - ppublish SO - Brain Behav. 2026 Apr;16(4):e71419. doi: 10.1002/brb3.71419. PMID- 41992511 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 1365-277X (Electronic) IS - 0952-3871 (Linking) VI - 39 IP - 2 DP - 2026 Apr TI - Psychometric Validation of the Turkish Version of the Nutrition Literacy Scale-Short Form (NL-SF12) for Use in Public Health Nutrition. PG - e70248 LID - 10.1111/jhn.70248 [doi] AB - BACKGROUND: Nutrition literacy is a key determinant of healthy dietary behaviors; however, brief and psychometrically robust instruments for assessing nutrition literacy in Turkish populations remain limited. This study aimed to adapt the Nutrition Literacy Scale-Short Form (NL-SF12) into Turkish and to evaluate its validity and reliability across different population groups. METHODS: This methodological, cross-sectional study included three independent samples from Turkiye: health-related university students (n = 470), non-health-related university students (n = 464), and adults from the general population (n = 546), totaling 1480 participants. Nutrition literacy was assessed using the NL-SF12. Criterion-related validity was examined using the e-Healthy Diet Literacy Scale (e-HDL). Construct validity was evaluated through confirmatory factor analysis. Reliability was assessed using internal consistency coefficients and test-retest correlations. RESULTS: Confirmatory factor analysis supported the original six-factor structure of the NL-SF12 across all population groups (factor loadings: 0.55-0.97), demonstrating acceptable model fit. Internal consistency was high across samples (Cronbach's alpha = 0.94; McDonald's omega = 0.94-0.95). Test-retest reliability indicated strong temporal stability (r = 0.82-0.92; p < 0.001). NL-SF12 scores showed moderate correlations with e-HDL scores across groups (r = 0.65; p < 0.001), supporting criterion-related validity. CONCLUSIONS: The Turkish version of the NL-SF12 is a valid and reliable instrument for assessing nutrition literacy across diverse population groups and represents a feasible tool for use in public health nutrition research and practice. CI - (c) 2026 British Dietetic Association. FAU - Sumen, Adem AU - Sumen A AUID- ORCID: 0000-0002-8876-400X AD - Department of Public Health Nursing, Kumluca Faculty of Health Sciences, Akdeniz University, Antalya, Turkiye. FAU - Ozer, Ulku AU - Ozer U AUID- ORCID: 0000-0002-8298-989X AD - Department of Fundamentals of Nursing, Kumluca Faculty of Health Sciences, Akdeniz University, Antalya, Turkiye. FAU - Turan, Fatma Dilek AU - Turan FD AUID- ORCID: 0000-0001-6130-6896 AD - Department of Pediatric Nursing, Kumluca Faculty of Health Sciences, Akdeniz University, Antalya, Turkiye. FAU - Unal, Aysun AU - Unal A AUID- ORCID: 0000-0001-5184-0008 AD - Department of Nursing Management, Kumluca Faculty of Health Sciences, Akdeniz University, Antalya, Turkiye. FAU - Oncel, Selma AU - Oncel S AUID- ORCID: 0000-0002-1882-1793 AD - Department of Public Health Nursing, Faculty of Nursing, Akdeniz University, Antalya, Turkiye. LA - eng PT - Journal Article PT - Validation Study PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Humans MH - Turkey MH - Female MH - *Psychometrics MH - *Health Literacy/statistics & numerical data MH - Reproducibility of Results MH - Cross-Sectional Studies MH - Adult MH - Male MH - Young Adult MH - Factor Analysis, Statistical MH - Surveys and Questionnaires/standards MH - *Public Health MH - Middle Aged MH - Diet, Healthy/psychology MH - Adolescent MH - Students MH - Universities OTO - NOTNLM OT - NL-SF12 OT - nutrition literacy OT - psychometric validation OT - reliability OT - scale adaptation OT - validity EDAT- 2026/04/17 13:25 MHDA- 2026/04/17 13:26 CRDT- 2026/04/17 00:53 PHST- 2026/04/01 00:00 [revised] PHST- 2026/02/02 00:00 [received] PHST- 2026/04/06 00:00 [accepted] PHST- 2026/04/17 13:26 [medline] PHST- 2026/04/17 13:25 [pubmed] PHST- 2026/04/17 00:53 [entrez] AID - 10.1111/jhn.70248 [doi] PST - ppublish SO - J Hum Nutr Diet. 2026 Apr;39(2):e70248. doi: 10.1111/jhn.70248. PMID- 41992342 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 1742-4755 (Electronic) IS - 1742-4755 (Linking) VI - 23 IP - 1 DP - 2026 Apr 16 TI - Developing recommendations to improve the experience of unplanned pregnancy: results from a multiphase study. LID - 10.1186/s12978-026-02324-x [doi] LID - 108 AB - BACKGROUND: Unplanned pregnancy is considered one of the most important health, social, and economic challenges in the field of reproductive health, which can have multiple negative effects on women's physical and psychological health and social relationships. This study aimed to develop interventions to improve the experience of women with unplanned pregnancy. METHODS: This study is part of a mixed-methods research with an exploratory sequential design. The study was conducted in two phases. In the first phase, a qualitative study was performed to clarify women's perceptions and experiences of unplanned pregnancy from the perspective of the participants (13 women with unplanned pregnancies, three midwives, and one gynecologist) and to identify their perceived needs. The participants were selected using purposive sampling. The inclusion criteria were unplanned pregnant women aged 18-45 years old and without any diagnosed physical or mental disorders. Semi-structured interviews were analyzed using conventional content analysis following the steps proposed by Graneheim and Lundman. Then, through a literature review, the components of pregnancy experiences and related proposed interventions were identified. In the second phase, the data obtained from both the qualitative phase and the literature review of the first phase were integrated, and 38 initial interventions were developed. Subsequently, these interventions were evaluated through three Delphi rounds by 15 experts from the fields of midwifery, obstetrics, and reproductive health, selected based on their experience of at least 5 years, academic position, and professional expertise. RESULTS: Thirty-two interventions were agreed upon and grouped into four domains: (1) education, counseling, and awareness-raising (such as providing prenatal health education, nutritional guidance, and psychological counseling) (2), improving the quality of care (such as ensuring respectful and personalized care, and continuously monitoring maternal needs) (3), strengthening maternal-fetal attachment (such as encouragement to talk and interact with the fetus), and (4) family and social support (such as partner education package and virtual peer support). The experts scored the interventions according to feasibility and importance. CONCLUSION: The 32 interventions developed and refined through expert consensus can serve as an evidence-based framework to enhance the experience of unplanned pregnant women, especially in communities with legal restrictions on abortion. These findings offer practical guidance for policymakers on how to train healthcare providers to deliver individualized care and holistic support that addresses the diverse needs of women. Additionally, healthcare systems should prioritize the development and dissemination of educational materials that cover the comprehensive topics identified in this study. FAU - Paiandeh, Masoumeh AU - Paiandeh M AD - Department of Midwifery, Faculty of Nursing and Midwifery, Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran. FAU - Nourizadeh, Roghaiyeh AU - Nourizadeh R AD - Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran. rnourizadeh@gmail.com. AD - Women's Reproductive Health Research Center, Al-Zahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran. rnourizadeh@gmail.com. FAU - Mehrabi, Esmat AU - Mehrabi E AD - Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran. AD - Women's Reproductive Health Research Center, Al-Zahra Hospital, Tabriz University of Medical Sciences, Tabriz, Iran. FAU - Mirghafourvand, Mojgan AU - Mirghafourvand M AD - Department of Midwifery, Faculty of Nursing and Midwifery, Tabriz University of Medical Sciences, Tabriz, Iran. AD - Social Determinants of Health Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. FAU - Mohammadi, Easa AU - Mohammadi E AD - Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran. LA - eng GR - IR.TBZMED.REC.1402.740/Tabriz University of Medical Sciences/ PT - Journal Article DEP - 20260416 PL - England TA - Reprod Health JT - Reproductive health JID - 101224380 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Pregnancy, Unplanned/psychology MH - Adult MH - Qualitative Research MH - Young Adult MH - Adolescent MH - Middle Aged MH - Family Planning Services PMC - PMC13202740 OAB - Unplanned pregnancy can be a stressful experience, particularly in countries where abortion is legally restricted. The aim of this study was to identify and develop practical interventions to improve the experiences of women facing unplanned pregnancy. This study explored the experiences and needs of women facing unplanned pregnancies through interviews with 13 women and 4 healthcare professionals. We also reviewed existing research to identify effective support strategies. Combining these findings, we developed 38 interventions, which were refined to 32 through expert consensus using three rounds of the Delphi method. These interventions fall into four key areas:1. Education, counseling, and awareness - Providing clear information, psychological support, and guidance helps women make informed decisions, reduces anxiety, and improves confidence. Healthcare providers can integrate counseling and educational materials into routine prenatal care.2. Improving quality of care - Respectful, personalized care and continuous attention to women's physical and emotional needs improve their overall experience. Training clinicians in compassionate communication and implementing quality-of-care standards ensures women feel valued and supported.3. Strengthening maternal - fetal attachment involves maternal monitoring of fetal movements, as well as encouragement to talk and interact with the fetus. These practices can enhance emotional adjustment and promote healthy behaviors. Providers can offer training in these techniques during standard visits, while policymakers can support attachment-focused modules in prenatal care guidelines.4. Family and social support - Involvement of partners, family, peers, and digital support platforms reduces isolation and enhances well-being. Clinics can facilitate partner participation and peer networks, and policymakers can fund community programs and promote partner engagement policies. These interventions offer practical strategies to improve the health, well-being, and care experiences of women navigating unplanned pregnancies. OABL- eng OTO - NOTNLM OT - Delphi method OT - Interventions OT - Iran OT - Mixed-methods research OT - Pregnancy experience OT - Unplanned pregnancy COIS- Declarations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/17 06:32 MHDA- 2026/06/28 13:04 PMCR- 2026/04/16 CRDT- 2026/04/17 00:22 PHST- 2025/06/21 00:00 [received] PHST- 2026/03/21 00:00 [accepted] PHST- 2026/06/28 13:04 [medline] PHST- 2026/04/17 06:32 [pubmed] PHST- 2026/04/17 00:22 [entrez] PHST- 2026/04/16 00:00 [pmc-release] AID - 10.1186/s12978-026-02324-x [pii] AID - 2324 [pii] AID - 10.1186/s12978-026-02324-x [doi] PST - epublish SO - Reprod Health. 2026 Apr 16;23(1):108. doi: 10.1186/s12978-026-02324-x. PMID- 41992207 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Apr 16 TI - Comparative performance analysis of AI-based large language models in assessing cervical vertebral maturation stages on lateral cephalometric radiographs. LID - 10.1186/s12903-026-08293-8 [doi] LID - 979 AB - BACKGROUND: The aim of this study was to evaluate the performance of artificial intelligence (AI)-based large language models (LLMs) in predicting cervical vertebral maturation (CVM) stages on lateral cephalometric radiographs. METHODS: This retrospective study evaluated the performance of AI-based LLMs in predicting CVM stages using 120 lateral cephalometric radiographs obtained from individuals aged 6-19 years. The radiographs, which included an equal number of samples from each CVM stage, were independently classified by two experienced orthodontists, with the consensus-established stages serving as the gold standard. Five distinct LLMs (GPT-4o, GPT-o3 pro, GPT-5, GPT-5 pro, and Grok-4) were tested in separate sessions using the same command for each image. Model performance was assessed using accuracy, correlation coefficients, Bland-Altman analysis, and mean absolute error (MAE). RESULTS: Exact-match accuracy of the AI-based LLMs ranged between 14% and 28%, while accuracy within +/- 1 stage tolerance ranged from 55% to 64%. GPT-4o demonstrated the highest correlation with the reference standard (rho = 0.616, p < 0.001), followed by GPT-5 pro (rho = 0.535). Other AI-based LLMs exhibited moderate correlations (rho = 0.3-0.4). Bland-Altman analyses indicated bias values close to zero but revealed wide limits of agreement. MAE values were comparable across AI-based LLMs, with no statistically significant differences (p > 0.05). CONCLUSIONS: Current LLMs did not exhibit clinically acceptable agreement with expert CVM assessments, showing wide error margins that limit their clinical utility. LLMs should presently be considered only as supportive tools. Further improvements in training and multimodal model design are needed to improve their diagnostic reliability. FAU - Erdem, Rusen AU - Erdem R AUID- ORCID: 0000-0002-5298-7949 AD - Department of Orthodontics, Faculty of Dentistry, Kafkas University, Kars, Turkiye. erdemrusenn@gmail.com. FAU - Yildirim, Ahmet AU - Yildirim A AUID- ORCID: 0009-0005-6804-1276 AD - Department of Orthodontics, Faculty of Dentistry, Zonguldak Bulent Ecevit University, Zonguldak, Turkiye. FAU - Genc, Yavuz Selim AU - Genc YS AUID- ORCID: 0000-0003-0556-2830 AD - Department of Orthodontics, Faculty of Dentistry, Giresun University, Giresun, Turkiye. FAU - Beser Gul, Busra AU - Beser Gul B AUID- ORCID: 0000-0002-7280-0168 AD - Department of Orthodontics, Faculty of Dentistry, Recep Tayyip Erdogan University, Rize, Turkiye. FAU - Naralan, Muhammed Enes AU - Naralan ME AUID- ORCID: 0000-0002-2444-4322 AD - Department of Oral and Dentomaxillofacial Radiology, Faculty of Dentistry, Recep Tayyip Erdogan University, Rize, Turkiye. FAU - Cicek, Orhan AU - Cicek O AUID- ORCID: 0000-0002-8172-6043 AD - Department of Orthodontics, Faculty of Dentistry, Zonguldak Bulent Ecevit University, Zonguldak, Turkiye. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260416 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Cervical Vertebrae/growth & development/diagnostic imaging MH - Large Language Models MH - Child MH - Retrospective Studies MH - *Cephalometry/methods MH - Adolescent MH - *Age Determination by Skeleton/methods MH - Young Adult MH - *Artificial Intelligence MH - Generative Artificial Intelligence MH - Female PMC - PMC13248458 OTO - NOTNLM OT - Artificial intelligence OT - Cervical vertebral maturation OT - Large language models OT - Lateral cephalogram OT - Orthodontics COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Kafkas University Non-Interventional Clinical Research Ethics Committee (Approval No: KAU-TFEK 2025/08/09; Date: 27 October 2025). Archival radiographs were used in anonymized form in accordance with this approval and the ethical principles outlined in the Declaration of Helsinki. Informed consent was obtained from all participants and their legal guardians involved in this study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/17 13:25 MHDA- 2026/06/28 13:04 PMCR- 2026/04/16 CRDT- 2026/04/17 00:12 PHST- 2025/11/28 00:00 [received] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/06/28 13:04 [medline] PHST- 2026/04/17 13:25 [pubmed] PHST- 2026/04/17 00:12 [entrez] PHST- 2026/04/16 00:00 [pmc-release] AID - 10.1186/s12903-026-08293-8 [pii] AID - 8293 [pii] AID - 10.1186/s12903-026-08293-8 [doi] PST - epublish SO - BMC Oral Health. 2026 Apr 16;26(1):979. doi: 10.1186/s12903-026-08293-8. PMID- 41992076 OWN - NLM STAT- MEDLINE DCOM- 20260806 LR - 20260926 IS - 1098-108X (Electronic) IS - 0276-3478 (Print) IS - 0276-3478 (Linking) VI - 59 IP - 8 DP - 2026 Aug TI - Acceptability, Feasibility, and Preliminary Effectiveness of a Mobile App for Teens With or at High Risk for Eating Disorders: A Three-Arm Pilot Randomized Controlled Trial Comparing Self-Help, Guided Self-Help, and Guided Self-Help With a Social Networking Component. PG - 1724-1739 LID - 10.1002/eat.70105 [doi] AB - OBJECTIVE: Given the wide treatment gap for eating disorders (EDs) and that these problems often emerge in adolescence, novel tools, such as app-based interventions, are needed to prevent and treat EDs in teens. However, questions remain about the optimal level of human support and features within these programs that could enhance outcomes (e.g., social networking). We conducted a pilot randomized controlled trial of a mobile app for teens with or at high risk for EDs, comparing self-help (control) to guided self-help (GSH) and GSH+ social networking (GSH+). METHOD: N = 148 teens with or at high risk for EDs recruited from social media and an online EDs screen were randomized. Participants had access to their assigned intervention for 3 months and completed surveys at baseline, 6 weeks, 3 months, and 6 months. RESULTS: Teen qualitative feedback illustrated positive perceptions about acceptability and feasibility of the tool and its impact on ED-related thoughts and behaviors. There were no significant differences across groups for the main outcome, global ED psychopathology, but there was a significant reduction for all groups over time (ps < 0.01; d = -0.93 from baseline to 6 months). While all intervention conditions had significant reductions in binge eating behaviors over time, the rate of reduction was greatest in the GSH condition (p < 0.001). CONCLUSIONS: Overall, our preliminary findings suggest that digital self-help interventions (both unguided and guided) may represent scalable interventions for teens with or at high risk for EDs, with coaching possibly augmenting outcomes for some subgroups. CI - (c) 2026 Wiley Periodicals LLC. FAU - Cavazos-Rehg, Patricia A AU - Cavazos-Rehg PA AUID- ORCID: 0000-0003-3352-1198 AD - Washington University School of Medicine, St. Louis, Missouri, USA. FAU - Fitzsimmons-Craft, Ellen E AU - Fitzsimmons-Craft EE AUID- ORCID: 0000-0001-7064-3835 AD - Washington University School of Medicine, St. Louis, Missouri, USA. AD - Washington University in St. Louis, St. Louis, Missouri, USA. FAU - Kasson, Erin AU - Kasson E AUID- ORCID: 0000-0003-4888-3319 AD - Washington University School of Medicine, St. Louis, Missouri, USA. FAU - Szlyk, Hannah S AU - Szlyk HS AUID- ORCID: 0000-0001-7337-8475 AD - Washington University School of Medicine, St. Louis, Missouri, USA. FAU - Li, Xiao AU - Li X AUID- ORCID: 0000-0002-3649-1820 AD - Washington University School of Medicine, St. Louis, Missouri, USA. FAU - Smith, Arielle C AU - Smith AC AUID- ORCID: 0000-0003-4679-1808 AD - Northwestern University, Evanston, Illinois, USA. FAU - D'Adamo, Laura AU - D'Adamo L AUID- ORCID: 0000-0001-9963-7316 AD - Drexel University, Philadelphia, Pennsylvania, USA. FAU - Lew, Daphne AU - Lew D AUID- ORCID: 0000-0001-5433-2367 AD - Washington University School of Medicine, St. Louis, Missouri, USA. FAU - Wilfley, Denise E AU - Wilfley DE AUID- ORCID: 0000-0002-3599-8689 AD - Washington University School of Medicine, St. Louis, Missouri, USA. LA - eng GR - K08 MH120341/MH/NIMH NIH HHS/United States GR - R34 MH119170/MH/NIMH NIH HHS/United States GR - National Science Foundation/ GR - F31 MH138068/MH/NIMH NIH HHS/United States GR - P30 DK056341/DK/NIDDK NIH HHS/United States GR - T90 NR021683/NR/NINR NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial DEP - 20260416 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Feeding and Eating Disorders/therapy/psychology/prevention & control MH - Pilot Projects MH - *Self Care/methods MH - *Mobile Applications MH - Male MH - Feasibility Studies MH - *Social Networking MH - *Patient Acceptance of Health Care MH - Treatment Outcome PMC - PMC13218351 MID - NIHMS2168086 OAB - Teens with eating disorders represent an important population to target for early, accessible interventions. The mobile app in the current study showed preliminary effectiveness in reducing eating disorder symptoms among teens. Larger trials will be needed to determine whether coaching may especially benefit those with high levels of binge eating or other subgroups, such as teens with higher co-morbid mental health concerns or those identifying as sexual and/or gender minorities. OABL- eng COIS- Patricia A. Cavazos-Rehg is a consultant for Rissana LLC, PredictView, and Woebot. Dr. Fitzsimmons-Craft receives royalties from UpToDate and has served as a consultant for Kooth. Hannah S. Szlyk is a paid consultant for Google Health. EDAT- 2026/04/17 13:25 MHDA- 2026/08/06 12:37 PMCR- 2026/08/06 CRDT- 2026/04/16 23:42 PHST- 2026/03/19 00:00 [revised] PHST- 2026/01/06 00:00 [received] PHST- 2026/04/06 00:00 [accepted] PHST- 2026/08/06 12:37 [medline] PHST- 2026/04/17 13:25 [pubmed] PHST- 2026/04/16 23:42 [entrez] PHST- 2026/08/06 00:00 [pmc-release] AID - EAT70105 [pii] AID - 10.1002/eat.70105 [doi] PST - ppublish SO - Int J Eat Disord. 2026 Aug;59(8):1724-1739. doi: 10.1002/eat.70105. Epub 2026 Apr 16. PMID- 41990566 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1875-595X (Electronic) IS - 0020-6539 (Print) IS - 0020-6539 (Linking) VI - 76 IP - 3 DP - 2026 Jun TI - Cone-Beam Computed Tomography-Based Three-Dimensional Phenotypes of Skeletal Class II Malocclusion in Yemeni Adults: A Principal Component and Cluster Analysis. PG - 109534 LID - S0020-6539(26)00128-0 [pii] LID - 10.1016/j.identj.2026.109534 [doi] LID - 109534 AB - INTRODUCTION AND AIMS: Skeletal Class II malocclusion is heterogeneous, and conventional two-dimensional cephalometry may not fully capture relevant three-dimensional (3D) craniofacial variation. This study aimed to identify 3D skeletal phenotypes of Class II malocclusion in Yemeni adults using cone-beam computed tomography (CBCT) and multivariate analysis. METHODS: This retrospective observational study included CBCT scans of 120 Yemeni adults with skeletal Class II malocclusion (56 males, 64 females; age range 16-30 years; mean 23.1 +/- 3.5 years) retrieved from the archives of the Department of Orthodontics, Faculty of Dentistry, Sana'a University. CBCT-derived cephalometric measurements were obtained from lateral reconstructions using Dolphin Imaging (version 12.0 Premium). Twenty prespecified skeletal variables were standardised and analysed by principal component analysis (PCA). Seven components were retained and entered into Ward's hierarchical cluster analysis. The optimal cluster solution was selected using dendrogram inspection, agglomeration coefficients, average silhouette, and clinical interpretability. Canonical discriminant analysis with leave-one-out classification was used for internal validation, and cluster distribution by sex was assessed using chi-square testing. RESULTS: The seven retained principal components explained 64.4% of the variance in the 20 skeletal variables. Cluster analysis identified five skeletal Class II phenotypes (Cluster 1, n = 34; Cluster 2, n = 24; Cluster 3, n = 32; Cluster 4, n = 24; Cluster 5, n = 6) representing different combinations of maxillary position, mandibular retrusion, mandibular plane angulation, and facial height pattern. The five-cluster solution showed acceptable internal separation (average silhouette = 0.253). Internal validation demonstrated robust discrimination, with an overall leave-one-out correct classification rate of 99.2%. Cluster distribution did not differ significantly by sex (chi-square P = .921). CONCLUSION: CBCT-based multivariate analysis identified five distinct skeletal phenotypes among Yemeni adults with skeletal Class II malocclusion, highlighting the heterogeneity of this condition and the limitations of relying only on sagittal descriptors such as ANB and Wits appraisal. Phenotype-specific 3D characterisation may support more individualised treatment planning and may provide clinically interpretable labels for future machine-learning studies. CLINICAL RELEVANCE: Phenotype-specific 3D characterisation of skeletal Class II malocclusion may support individualised treatment planning (eg, growth modification, camouflage, or orthognathic approaches). The resulting cluster labels may also serve as clinically interpretable phenotypic descriptors for future machine-learning studies, but no AI modelling was performed in the present work. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Hafedh, Salah M Ben AU - Hafedh SMB AD - Department of Orthodontics, Faculty of Dentistry, Sana'a University, Sana'a, Yemen. Electronic address: salah.hafedh@gmc-ye.com. FAU - Al-Harazi, Ghamdan AU - Al-Harazi G AD - Department of Orthodontics, Faculty of Dentistry, Sana'a University, Sana'a, Yemen. FAU - Ishaq, Ramy Abdulrahman AU - Ishaq RA AD - Department of Orthodontics, Faculty of Dentistry, Sana'a University, Sana'a, Yemen. LA - eng PT - Journal Article PT - Observational Study DEP - 20260415 PL - England TA - Int Dent J JT - International dental journal JID - 0374714 SB - IM MH - Humans MH - Female MH - *Cone-Beam Computed Tomography/methods MH - Principal Component Analysis MH - *Malocclusion, Angle Class II/diagnostic imaging MH - Cluster Analysis MH - Phenotype MH - *Imaging, Three-Dimensional/methods MH - Retrospective Studies MH - Male MH - Adolescent MH - Cephalometry/methods MH - Adult MH - Young Adult MH - Yemen MH - Clustering Algorithms PMC - PMC13101279 OTO - NOTNLM OT - Cluster analysis OT - Cone-beam computed tomography OT - Malocclusion, Angle Class II OT - Orthodontics OT - Phenotype OT - Principal component analysis COIS- Conflict of interest None disclosed. EDAT- 2026/04/17 13:25 MHDA- 2026/05/05 06:33 PMCR- 2026/04/15 CRDT- 2026/04/16 18:06 PHST- 2026/01/26 00:00 [received] PHST- 2026/02/15 00:00 [revised] PHST- 2026/03/06 00:00 [accepted] PHST- 2026/05/05 06:33 [medline] PHST- 2026/04/17 13:25 [pubmed] PHST- 2026/04/16 18:06 [entrez] PHST- 2026/04/15 00:00 [pmc-release] AID - S0020-6539(26)00128-0 [pii] AID - 109534 [pii] AID - 10.1016/j.identj.2026.109534 [doi] PST - ppublish SO - Int Dent J. 2026 Jun;76(3):109534. doi: 10.1016/j.identj.2026.109534. Epub 2026 Apr 15. PMID- 41990469 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 266 DP - 2026 Jun TI - On the associations between adolescent social media use and health outcomes: An exploratory specification curve analysis and comparison with other concurrent predictors. PG - 106783 LID - S0001-6918(26)00584-6 [pii] LID - 10.1016/j.actpsy.2026.106783 [doi] AB - The impact of social media on the health of adolescents is an intensely debated topic globally, with conflicting views among researchers, caregivers, and policymakers. Empirical findings remain inconclusive, largely due to methodological and conceptual oversights. To address these oversights, we applied specification curve analysis, a computational method which reduces bias from selective analytical choices, to examine associations between time spent on social media and four related but distinct health outcomes - psychological well-being, mental health, health behaviours, and risk behaviours - in 15-and 16-year-olds in the west of Ireland (N = 2876). While most model specifications indicated a negative association between social media and health outcomes, some associations were positive (e.g., time on social media and vigorous physical activity for boys). Aside from anger management and alcohol consumption, most associations fall below accepted thresholds for reliability or clinical significance, suggesting that most associations may be indistinguishable from statistical noise. Notably, when compared to other relevant factors, time on social media emerged as one of the least influential predictors of adolescent health. While some specific associations between social media and adolescent health are statistically reliable, the overall effects at the population level are small and may not be clinically relevant. CI - Copyright (c) 2026 The Author. Published by Elsevier B.V. All rights reserved. FAU - Whelan, Eoin AU - Whelan E AD - Business Information Systems, J.E. Cairnes School of Business & Economics, University of Galway, Galway, Ireland. Electronic address: eoin.whelan@universityofgalway.ie. LA - eng PT - Journal Article DEP - 20260415 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM MH - Humans MH - Adolescent MH - *Social Media/statistics & numerical data MH - Male MH - Female MH - *Adolescent Behavior/psychology MH - *Health Behavior MH - *Mental Health/statistics & numerical data MH - Ireland MH - Media Exposure MH - *Adolescent Health/statistics & numerical data MH - Psychological Well-Being MH - *Risk-Taking MH - Digital Media OTO - NOTNLM OT - Adolescent health OT - Mental health OT - Social media OT - Specification curve analysis OT - Well-being COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/17 13:25 MHDA- 2026/05/15 06:29 CRDT- 2026/04/16 18:03 PHST- 2025/11/21 00:00 [received] PHST- 2026/03/18 00:00 [revised] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/05/15 06:29 [medline] PHST- 2026/04/17 13:25 [pubmed] PHST- 2026/04/16 18:03 [entrez] AID - S0001-6918(26)00584-6 [pii] AID - 10.1016/j.actpsy.2026.106783 [doi] PST - ppublish SO - Acta Psychol (Amst). 2026 Jun;266:106783. doi: 10.1016/j.actpsy.2026.106783. Epub 2026 Apr 15. PMID- 41989430 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1573-2665 (Electronic) IS - 0141-8955 (Print) IS - 0141-8955 (Linking) VI - 49 IP - 3 DP - 2026 May TI - Real-Life Application of a Point-of-Care Biosensor for Phenylalanine in Patients With Phenylketonuria. PG - e70187 LID - 10.1002/jimd.70187 [doi] LID - e70187 AB - Phenylketonuria (PKU) is a rare metabolic disorder causing elevated phenylalanine (PHE) levels requiring lifelong dietary or pharmacological management and regular monitoring. Current PHE monitoring methods, such as tandem mass spectrometry (FIA-MS/MS), are laboratory and sample transport-dependent, leading to delays in obtaining results. This highlights the need for accessible point-of-care (PoC) solutions. Building on a previously developed bioluminescence-based PHE quantification method, we created a PoC PHE sensor integrated with a smartphone app (phenyx app) for real-time monitoring and data sharing. In a clinical study with PKU patients, we evaluated the reliability of the sensor and the app by comparing at-home PHE measurements with dried blood samples (DBS) analyzed using the gold standard FIA-MS/MS. We also assessed time differences between sampling and results, sensor practicality, and user experience. Forty-seven PKU patients (median age 10.0 years, range 0.7-53.4) performed one supervised and four at-home measurements using the PHE sensor, alongside DBS sampling for FIA-MS/MS. The sensor showed higher PHE values than FIA-MS/MS, with a mean difference of 84.8 mumol/L (p = 0.0017). Variability was influenced by test supervision (clinic vs. home) and test kit age (greater difference in older batches, p = 0.001). Usability of the PHE sensor and phenyx app was rated favorably; all patients preferred the PHE sensor over laboratory testing. PoC measurement using the PHE sensor and phenyx app is feasible, reliable, and provides rapid results comparable to FIA-MS/MS, representing a key step toward patient self-testing. Trial Registration: NCT05998109, NCT06940193, DRKS00031972. CI - (c) 2026 The Author(s). Journal of Inherited Metabolic Disease published by John Wiley & Sons Ltd on behalf of SSIEM. FAU - Gondrand, Corentin AU - Gondrand C AD - Department of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg, Germany. FAU - Reischl-Hajiabadi, Anna T AU - Reischl-Hajiabadi AT AUID- ORCID: 0000-0002-7766-4847 AD - Medical Faculty of Heidelberg, Department of Pediatrics, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany. FAU - Bonedeau, Estelle AU - Bonedeau E AD - Department of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg, Germany. FAU - Weiss, Nicolas AU - Weiss N AD - Phellow Seven GmbH, Heidelberg, Germany. FAU - Schneider, Gerd AU - Schneider G AD - Phellow Seven GmbH, Heidelberg, Germany. FAU - Fahn, Maurice AU - Fahn M AD - Phellow Seven GmbH, Heidelberg, Germany. FAU - Myers, Frederic AU - Myers F AD - Frederic Myers Consulting (JERY), Reutlingen, Germany. FAU - Stadle, Philipp Minel AU - Stadle PM AD - Frederic Myers Consulting (JERY), Reutlingen, Germany. FAU - Jeltsch, Kathrin AU - Jeltsch K AD - Medical Faculty of Heidelberg, Department of Pediatrics, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany. FAU - Hoffmann, Georg F AU - Hoffmann GF AD - Medical Faculty of Heidelberg, Department of Pediatrics, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany. FAU - Okun, Jurgen G AU - Okun JG AD - Medical Faculty of Heidelberg, Department of Pediatrics, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany. FAU - Haas, Dorothea AU - Haas D AD - Medical Faculty of Heidelberg, Department of Pediatrics, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany. FAU - Garbade, Sven F AU - Garbade SF AUID- ORCID: 0000-0002-7420-4757 AD - Medical Faculty of Heidelberg, Department of Pediatrics, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany. FAU - Johnsson, Kai AU - Johnsson K AD - Department of Chemical Biology, Max Planck Institute for Medical Research, Heidelberg, Germany. AD - Ecole Polytechnique Federale de Lausanne, Institute of Chemical Sciences and Engineering, NCCR in Chemical Biology, Lausanne, Switzerland. FAU - Opladen, Thomas AU - Opladen T AUID- ORCID: 0000-0003-4349-7662 AD - Medical Faculty of Heidelberg, Department of Pediatrics, Division of Pediatric Neurology and Metabolic Medicine, Heidelberg University, Heidelberg, Germany. LA - eng SI - ClinicalTrials.gov/NCT06940193 SI - ClinicalTrials.gov/NCT05998109 GR - Fraunhofer-Max Planck Cooperation Program/ GR - 955623/Marie Sklodowska-Curie grant agreement (H2020-MSCAITN-CONSENSE)/ GR - M. Lomtadze/ PT - Journal Article PT - Observational Study PL - United States TA - J Inherit Metab Dis JT - Journal of inherited metabolic disease JID - 7910918 RN - 47E5O17Y3R (Phenylalanine) SB - IM MH - Adolescent MH - Adult MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Middle Aged MH - Young Adult MH - *Biosensing Techniques/methods MH - Dried Blood Spot Testing MH - *Phenylalanine/blood MH - *Phenylketonurias/blood/diagnosis MH - *Point-of-Care Systems MH - Rapid Diagnostic Tests MH - Reproducibility of Results MH - Smartphone MH - Tandem Mass Spectrometry PMC - PMC13086054 OTO - NOTNLM OT - PKU OT - Phenylketonuria OT - at-home test OT - biosensor OT - phenylalanine hydroxylase deficiency OT - point-of-care testing COIS- Kai Johnsson is listed as inventor on patents on bioluminescent sensor proteins owned by MPG. All other authors declare no conflicts of interest. EDAT- 2026/04/17 04:10 MHDA- 2026/04/17 04:11 PMCR- 2026/04/16 CRDT- 2026/04/16 10:54 PHST- 2026/03/17 00:00 [revised] PHST- 2025/11/26 00:00 [received] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/04/17 04:11 [medline] PHST- 2026/04/17 04:10 [pubmed] PHST- 2026/04/16 10:54 [entrez] PHST- 2026/04/16 00:00 [pmc-release] AID - JIMD70187 [pii] AID - 10.1002/jimd.70187 [doi] PST - ppublish SO - J Inherit Metab Dis. 2026 May;49(3):e70187. doi: 10.1002/jimd.70187. PMID- 41989429 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260723 IS - 1939-1501 (Electronic) IS - 0893-164X (Linking) VI - 40 IP - 5 DP - 2026 Aug TI - A cross-national examination of the Compensatory Eating and Behaviors in Response to Alcohol Consumption Scale (CEBRACS) across six countries. PG - 513-525 LID - 10.1037/adb0001153 [doi] AB - OBJECTIVE: The Compensatory Eating and Behaviors in Response to Alcohol Consumption Scale (CEBRACS) is a commonly used measure to assess food and alcohol disturbance (FAD; i.e., use of compensatory behaviors before, during, or after a drinking episode to offset alcohol-related calories and/or enhance alcohol effects). However, its cross-national utility remains largely unexamined. This study evaluated the psychometric properties, frequency, and concurrent utility of the CEBRACS in a cross-national sample. METHOD: Participants were 2,886 college students (United States [n = 1,155], Argentina [n = 537], Spain [n = 597], South Africa [n = 287], England [n = 170], Canada [n = 137]) reporting past-month FAD (M(age) = 20.81; 70.4% female) who completed an online survey assessing FAD and alcohol-related behaviors. RESULTS: Confirmatory factor analyses of the CEBRACS's original and alternative structures indicated persistent model estimation warnings, though some models showed seemingly acceptable fit in select countries. Despite these limitations, item-level analyses demonstrated consistent endorsement of FAD behaviors, with items relating to engaging in exercise behaviors to compensate for alcohol-related calories, as well as disordered eating behaviors to enhance the effects of alcohol, being the most frequently endorsed. Endorsement rates were generally highest among participants from England and lowest in Argentina and Spain. Across all six countries, CEBRACS items were positively associated with alcohol-related outcomes (i.e., frequency, quantity, and/or consequences). CONCLUSIONS: Our findings highlight several psychometric limitations of the CEBRACS in a cross-national sample but suggest that examining individual items may still provide valuable insights into FAD-related behaviors. The results underscore the need for continued cross-national research on FAD. (PsycInfo Database Record (c) 2026 APA, all rights reserved). FAU - Berry, Katherine A AU - Berry KA AUID- ORCID: 0000-0002-2632-7437 AD - Department of Psychology, University of Wyoming. FAU - Hernandez Puelma, Javiera A AU - Hernandez Puelma JA AUID- ORCID: 0009-0005-1585-9365 AD - Department of Psychological Sciences, William & Mary. FAU - Herchenroeder, Luke AU - Herchenroeder L AD - Department of Leadership, Ethics, and Law, United States Naval Academy. FAU - Looby, Alison AU - Looby A AD - Department of Psychology, University of Wyoming. FAU - Bravo, Adrian J AU - Bravo AJ AD - Department of Psychological Sciences, William & Mary. CN - Cross-Cultural Addictions Study Team LA - eng GR - Fondo Nacional de Ciencia y Tecnologia/ GR - Consejo Nacional de Investigaciones Cientificas y Tecnicas/ PT - Journal Article DEP - 20260416 PL - United States TA - Psychol Addict Behav JT - Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors JID - 8802734 SB - IM MH - Humans MH - Female MH - Psychometrics MH - *Alcohol Drinking/psychology MH - Young Adult MH - Cross-Cultural Comparison MH - Male MH - United States MH - Canada MH - Argentina MH - England MH - Spain MH - South Africa MH - Students/statistics & numerical data MH - Adult MH - Adolescent MH - *Feeding Behavior MH - Surveys and Questionnaires MH - Universities EDAT- 2026/04/16 12:42 MHDA- 2026/07/23 18:35 CRDT- 2026/04/16 10:53 PHST- 2026/07/23 18:35 [medline] PHST- 2026/04/16 12:42 [pubmed] PHST- 2026/04/16 10:53 [entrez] AID - 2027-56014-001 [pii] AID - 10.1037/adb0001153 [doi] PST - ppublish SO - Psychol Addict Behav. 2026 Aug;40(5):513-525. doi: 10.1037/adb0001153. Epub 2026 Apr 16. PMID- 41988155 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260416 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Imaging diagnosis and sequential conservative treatment of pediatric traumatic duodenal intraluminal hematoma. PG - 1710734 LID - 10.3389/fped.2026.1710734 [doi] LID - 1710734 AB - AIM: To explore the imaging, diagnosis, and treatment of traumatic duodenal intramural hematoma in children, improve diagnostic accuracy, and shorten hospitalization time. METHODS: A retrospective analysis of five children with traumatic duodenal intramural hematoma. RESULTS: One child had a descending duodenal wall hematoma, two had horizontal wall hematomas, one had an ascending wall hematoma, and one case involving both the descending and ascending parts. All five children were initially diagnosed by computed tomography (CT). The typical images showed "ice melting sign" and "fissure sign," with no lesion enhancement. Magnetic resonance imaging (MRI) in two children on follow-up showed spindle-shaped or quasi-circular intestinal walls protruding towards the intestinal lumen, local intestinal lumen stenosis, high signal intensity on T1W1 and uneven high signal intensity on T2W1, with no enhancement of the lesion. All five patients underwent multiple dynamic follow-up examinations using ultrasound, which clearly displayed the structure of the intestinal wall, absorption of hematoma, and the degree of intestinal obstruction. CONCLUSION: Conservative treatment, such as gastrointestinal decompression and intravenous nutrition, for pediatric duodenal wall hematoma has a good prognosis results in favorable outcomes. Initial CT diagnosis combined with multiple ultrasound follow-up has high specificity for the diagnosis and treatment of this disease. CI - (c) 2026 Weng, Zhou, Qin and Wen. FAU - Weng, Xiaoyan AU - Weng X AD - Ultrasound Department of Women and Children's Hospital Affiliated to Ningbo University, Zhejiang, China. FAU - Zhou, Qianqin AU - Zhou Q AD - Neonatal Monitoring Center of Women and Children's Hospital Affiliated to Ningbo University, Zhejiang, China. FAU - Qin, Zhaofan AU - Qin Z AD - Imaging Department of Women and Children's Hospital Affiliated to Ningbo University, Zhejiang, China. FAU - Wen, Gang AU - Wen G AD - Department of Pediatric Surgery, Affiliated Women and Children's Hospital of Ningbo University, Zhejiang, China. LA - eng PT - Journal Article DEP - 20260331 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13076290 OTO - NOTNLM OT - children OT - conservative treatment OT - duodenal hematoma OT - intestinal obstruction OT - ultrasonography COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/16 13:09 MHDA- 2026/04/16 13:10 PMCR- 2026/03/31 CRDT- 2026/04/16 04:27 PHST- 2026/02/11 00:00 [received] PHST- 2025/12/01 00:00 [revised] PHST- 2026/02/13 00:00 [accepted] PHST- 2026/04/16 13:10 [medline] PHST- 2026/04/16 13:09 [pubmed] PHST- 2026/04/16 04:27 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - 10.3389/fped.2026.1710734 [doi] PST - epublish SO - Front Pediatr. 2026 Mar 31;14:1710734. doi: 10.3389/fped.2026.1710734. eCollection 2026. PMID- 41987974 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260416 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - The impact mechanism of green exercise on college students' suicidal ideation: a mediation analysis based on entrance anxiety. PG - 1735347 LID - 10.3389/fpsyg.2026.1735347 [doi] LID - 1735347 AB - PURPOSE: This study aimed to examine the relationship between green exercise and suicidal ideation among first-year university students and to explore the mediating role of entrance anxiety in this association. METHODS: A total of 713 freshmen participated in a cross-sectional survey using standardized questionnaires assessing green exercise, entrance anxiety, and suicidal ideation. Demographic variables (gender, family economic status, place of origin, and only-child status) were controlled. Data were analyzed with SPSS 27.0 and AMOS 26.0. Reliability, validity, and common method bias were tested, followed by structural equation modeling (SEM) and a bias-corrected bootstrapping analysis with 5,000 resamples to examine direct and indirect effects. RESULTS: The SEM results indicated that green exercise significantly reduced entrance anxiety (beta = -0.36, p < 0.001) and suicidal ideation (beta = -0.42, p < 0.001), whereas entrance anxiety positively predicted suicidal ideation (beta = 0.40, p < 0.001). Bootstrapping confirmed that entrance anxiety partially mediated the relationship between green exercise and suicidal ideation. The total effect of green exercise on suicidal ideation was significant (beta = -0.57, p < 0.001), including a direct effect (beta = -0.42, 73.68%) and an indirect effect through entrance anxiety (beta = -0.15, 26.32%), with confidence intervals excluding zero. CONCLUSION: Green exercise effectively alleviates entrance anxiety and reduces suicidal ideation among university freshmen. These findings highlight the mental health benefits of outdoor physical activity and suggest that integrating green exercise into campus life may serve as an effective preventive strategy against anxiety and suicidal ideation. CI - Copyright (c) 2026 Kong, Peng, Chen, Liu and Yin. FAU - Kong, Mingmin AU - Kong M AD - School of Sports Training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Peng, Bo AU - Peng B AD - School of Sports Training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Chen, Weisong AU - Chen W AD - School of Sports Training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Liu, Tong AU - Liu T AD - School of Sports Training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Yin, Zhongen AU - Yin Z AD - College of Physical Education and Health Management, Chongqing University of Education, Nan'an, Chongqing, China. LA - eng PT - Journal Article DEP - 20260331 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13077586 OTO - NOTNLM OT - college freshmen OT - entrance anxiety OT - green exercise OT - mediation analysis OT - structural equation modeling OT - suicidal ideation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/16 13:09 MHDA- 2026/04/16 13:10 PMCR- 2026/03/31 CRDT- 2026/04/16 04:25 PHST- 2025/11/14 00:00 [received] PHST- 2026/03/03 00:00 [revised] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/04/16 13:10 [medline] PHST- 2026/04/16 13:09 [pubmed] PHST- 2026/04/16 04:25 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1735347 [doi] PST - epublish SO - Front Psychol. 2026 Mar 31;17:1735347. doi: 10.3389/fpsyg.2026.1735347. eCollection 2026. PMID- 41987293 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 1746-4358 (Electronic) IS - 1746-4358 (Linking) VI - 21 IP - 1 DP - 2026 Apr 15 TI - An investigation into the status of human milk feeding in very low birth weight infants: a multicenter study. LID - 10.1186/s13006-026-00841-w [doi] LID - 50 AB - BACKGROUND: Human milk provides essential health benefits for very low birth weight infants (VLBWIs). Nevertheless, the utilization patterns of human milk in Chinese neonatal intensive care units (NICUs) remain inadequately characterized. The objective of this multicenter study was to evaluate the current status and variations in human milk feeding practices among diverse types of medical institutions, providing baseline data to support the implementation of full - process human milk feeding in NICUs. METHODS: A prospective observational study was conducted from July 2021 to July 2022, involving 725 VLBWIs admitted to the NICUs of 16 hospitals in China. Data on infant demographics, clinical outcomes, and detailed feeding records were systematically collected using a standardized questionnaire. A customized human milk feeding module was developed within a multicenter database platform to ensure consistent data capture. All data were entered locally by trained research staff, with subsequent centralized auditing and validation by the research team. Statistical analyses included descriptive statistics and chi-square tests to evaluate differences in feeding practices across hospital categories. RESULTS: The cohort consisted of 362 males (49.9%) and 363 females (50.1%), with mean gestational age 29.08 +/- 1.65 weeks and birth weight 1154.50 +/- 208.27 g. The overall human milk feeding rate was 52.3%, with significant disparities among hospital types: general hospitals (4.1%), children's hospitals (74.5%), and maternal and child health hospitals (89.7%) (chi(2)=362.141, P < 0.001). Donor human milk was available in 7 hospitals (43.8%), with 31.9% of infants receiving it during hospitalization. Initial feeding was predominantly formula-based (64.4%), while mother's own milk as initial feeding was uncommon (6.5%). Exclusive human milk feeding duration averaged 53.0 days (IQR 23.0-103.0), significantly longer than exclusive formula feeding (34.0 days, IQR 13.8-46.0). CONCLUSIONS: Substantial variations exist in human milk feeding practices for VLBWIs across Chinese NICUs, with overall utilization rates lower than international benchmarks. These findings highlight the need for standardized protocols and enhanced support systems to promote human milk feeding in this vulnerable population. FAU - Wang, Yan AU - Wang Y AD - Department of Neonatology, Anhui Provincial Children's Hospital, Hefei, China. FAU - Zhao, Lulu AU - Zhao L AD - Xiangyun County Maternal and Child Health Care Hospital, Dali Bai Autonomous Prefecture, Dali, China. AD - School of Nursing, Fudan University, Shanghai, China. FAU - Ma, Yuelan AU - Ma Y AD - Neonatal Intensive Care Unit, Suzhou Municipal Hospital, Suzhou, China. FAU - Xiao, Juan AU - Xiao J AD - Department of Neonatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. FAU - Zhang, Lili AU - Zhang L AD - Department of Neonatology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. FAU - Lyu, Tianchan AU - Lyu T AD - Neonatal Intensive Care Unit, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, China. FAU - Rong, Hui AU - Rong H AD - Neonatal Intensive Care Unit, Children's Hospital of Nanjing Medical University, Nanjing, China. FAU - Liu, Dan AU - Liu D AD - Department of Neonatology, Zhejiang Maternal Hospital, Hangzhou, China. FAU - Wang, Hua AU - Wang H AD - Department of Neonatology, Zhejiang Maternal Hospital, Hangzhou, China. FAU - Chen, Xiaochun AU - Chen X AD - Neonatal Intensive Care Unit, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China. FAU - Gu, Weiwei AU - Gu W AD - Neonatal Intensive Care Unit, Ningbo Women and Children's Hospital, Ningbo, China. FAU - Fan, Qiaoling AU - Fan Q AD - Neonatal Intensive Care Unit, Children's Hospital of Shanghai, Shanghai, China. FAU - Huang, Meiyuan AU - Huang M AD - Department of Nursing, Hainan Women and Children's Medical Centre, Haikou, China. FAU - Tang, Yunfei AU - Tang Y AD - Pediatric Department, Wuxi Children's Hospital, Wuxi, China. FAU - Li, Dan AU - Li D AD - Fujian Key Laboratory of Neonatal Diseases, Xiamen Key Laboratory of Neonatal Diseases, Xiamen Children's Hospital (Children's Hospital of Fudan University at Xiamen), Xiamen, China. FAU - Qin, An AU - Qin A AD - International Peace Maternity & Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Li, Xiaoxia AU - Li X AD - Department of Neonatology, People's Hospital of Longhua, Shenzhen, China. FAU - Tang, Yingzi AU - Tang Y AD - Department of Neonatology, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, 61 Xiangzhu Avenue, Nanning, China. 2447345448@qq.com. FAU - Hu, Xiaojing AU - Hu X AD - Neonatal Intensive Care Unit, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, China. humama2015@126.com. AD - Fujian Key Laboratory of Neonatal Diseases, Xiamen Key Laboratory of Neonatal Diseases, Xiamen Children's Hospital (Children's Hospital of Fudan University at Xiamen), Xiamen, China. humama2015@126.com. LA - eng GR - EKXDPY202305/National Children's Medical Centre Subject Leader Development Program/ GR - EKYX202405/"Medicine + X" Interdisciplinary Innovation Team Incubation Project/ PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260415 PL - England TA - Int Breastfeed J JT - International breastfeeding journal JID - 101251562 SB - IM MH - Humans MH - *Infant, Very Low Birth Weight MH - Female MH - Infant, Newborn MH - *Milk, Human MH - Intensive Care Units, Neonatal MH - Prospective Studies MH - Male MH - China MH - *Breast Feeding/statistics & numerical data MH - Infant PMC - PMC13218054 OTO - NOTNLM OT - Feeding OT - Human milk OT - Multi-center OT - Neonatal intensive care unit OT - Very low birth weight infant COIS- Declarations. Ethical approval: This study was conducted in accordance with the Declaration of Helsinki (2013 revision) and received ethical approval from the Institutional Ethics Committee of Children's Hospital of Fudan University (Ethics Number: 2020 - 533). Written informed consent was obtained from all participants or their legal guardians prior to data collection. Throughout the processes of data management, storage, analysis, and sharing, the privacy and anonymity of the research subjects were strictly protected. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/16 13:09 MHDA- 2026/06/28 13:04 PMCR- 2026/04/15 CRDT- 2026/04/16 01:16 PHST- 2025/08/25 00:00 [received] PHST- 2026/04/08 00:00 [accepted] PHST- 2026/06/28 13:04 [medline] PHST- 2026/04/16 13:09 [pubmed] PHST- 2026/04/16 01:16 [entrez] PHST- 2026/04/15 00:00 [pmc-release] AID - 10.1186/s13006-026-00841-w [pii] AID - 841 [pii] AID - 10.1186/s13006-026-00841-w [doi] PST - epublish SO - Int Breastfeed J. 2026 Apr 15;21(1):50. doi: 10.1186/s13006-026-00841-w. PMID- 41987171 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Apr 15 TI - A feasibility study exploring precarious employment and stress-related health among women. LID - 10.1186/s12889-026-27366-5 [doi] LID - 1556 AB - BACKGROUND: Stress is a hypothesized mechanism through which precarious employment (PE) may contribute to poor health; however, there is a limited understanding of this potential mechanism in the U.S. This study aimed to (1) provide preliminary insights into the biological stress profiles of women experiencing varying levels of PE and (2) test the feasibility of at-home collection of stress biomarkers, c-reactive protein (CRP), and salivary cortisol, among women in Chicago, Illinois. METHODS: We recruited 101 working-age women between August-October 2023. An online survey collected information on demographics, PE, and self-reported mental (Center for Epidemiologic Studies Depression Scale, Cohen's Perceived Stress Scale) and physical (self-reported health, body mass index) health. We mailed home-collection kits to collect capillary blood (120 𝜇L) and saliva (3 samples on 2 workdays). We used 27 employment indicators to construct a multidimensional PE score (PES) (range:0-10) and estimated descriptive statistics overall and by tertile of PE. RESULTS: We reached our recruitment target of ~ 50 women/month, and 70% returned the test kits. The sample was diverse in age (18-40 years: 57%, 41-64 years: 43%) and education ([Formula: see text]highschool: 11%, some college: 29%, [Formula: see text]bachelor's: 60%). Non-Hispanic (NH)-Black (33%) and Hispanic (36%) women were over-represented, compared to NH-White women (28%). More than half earned <$40,000, and the average PES was 3.6 (SE = 0.3). The most precariously employed women identified as NH-Black and Hispanic, had lower levels of educational attainment, experienced discrimination and had poorer self-reported physical and mental health. Those lost-to-follow-up between the online survey and biospecimen collection were lower-education, lower-income, more precariously employed, identified as Hispanic, and had poorer health. Biomarker patterns across PE tertiles were inconsistent; however, there was some suggestive evidence that the most precariously employed group may have lower recovery cortisol trends throughout the day, compared to the low and mid PE groups. CONCLUSIONS: We demonstrate the feasibility of at-home data collection of biospecimen samples among working women. Larger studies of PE and health are warranted. FAU - Oddo, Vanessa M AU - Oddo VM AD - Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, 1919 W Taylor Street, MC 517, Chicago, IL, 60612, USA. voddo@uic.edu. AD - University of Illinois Cancer Center, IL 60612, Chicago, USA. voddo@uic.edu. FAU - Andrea, Sarah B AU - Andrea SB AD - School of Public Health, Oregon Health and Sciences University-Portland State University, Portland, Oregon, USA. FAU - Winkler, Megan R AU - Winkler MR AD - Department of Behavioral, Social and Health Education Sciences, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA. FAU - Ahonen, Emily Q AU - Ahonen EQ AD - Division of Occupational and Environmental Health, School of Medicine, University of Utah, Salt Lake City, Utah, USA. FAU - Bammler, Theo K AU - Bammler TK AD - Department of Environmental and Occupational Health Sciences, Interdisciplinary Center for Exposures, Diseases, Genomics and Environment, School of Public Health, University of Washington, Seattle, Washington, USA. FAU - Tussing-Humphreys, Lisa M AU - Tussing-Humphreys LM AD - Department of Kinesiology and Nutrition, College of Applied Health Sciences, University of Illinois Chicago, 1919 W Taylor Street, MC 517, Chicago, IL, 60612, USA. AD - University of Illinois Cancer Center, IL 60612, Chicago, USA. FAU - Hajat, Anjum AU - Hajat A AD - Department of Epidemiology, School of Public Health, University of Washington, Seattle, Washington, USA. LA - eng GR - RG-22-149-01-IRG/University of Illinois Cancer Center's American Cancer Society Institutional Research Grant/ GR - R00MD012807/MD/NIMHD NIH HHS/United States GR - U19OH012304/Centers for Disease Control, Prevention/National Institute for Occupational Safety and Health grant/ GR - P30ES007033/University of Washington's Interdisciplinary Center for Exposures, Diseases, Genomics and Environment/ GR - R01AG060011/AG/NIA NIH HHS/United States PT - Journal Article DEP - 20260415 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - WI4X0X7BPJ (Hydrocortisone) RN - 0 (Biomarkers) RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Humans MH - Female MH - Feasibility Studies MH - Adult MH - *Job Security MH - Saliva/chemistry MH - Hydrocortisone/analysis MH - Middle Aged MH - *Stress, Psychological/epidemiology MH - Young Adult MH - Biomarkers/analysis MH - Chicago/epidemiology MH - Adolescent MH - C-Reactive Protein/analysis MH - *Health Status MH - *Employment/psychology MH - Subjective Stress PMC - PMC13173993 OTO - NOTNLM OT - Biological stress OT - C-reactive protein OT - Chicago Illinois OT - Cortisol OT - Employment quality OT - Social determinant of health COIS- Declarations. Ethics approval and consent to participate: The procedures followed in this pilot study were in accordance with ethical standards set by the Declaration of Helsinki for human research. Approval was obtained from the Institutional Review Board of the University of Illinois Chicago (STUDY2023-0093) and informed consent was obtained from all participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/16 13:09 MHDA- 2026/06/27 22:35 PMCR- 2026/04/15 CRDT- 2026/04/16 01:10 PHST- 2025/02/05 00:00 [received] PHST- 2026/04/07 00:00 [accepted] PHST- 2026/06/27 22:35 [medline] PHST- 2026/04/16 13:09 [pubmed] PHST- 2026/04/16 01:10 [entrez] PHST- 2026/04/15 00:00 [pmc-release] AID - 10.1186/s12889-026-27366-5 [pii] AID - 27366 [pii] AID - 10.1186/s12889-026-27366-5 [doi] PST - epublish SO - BMC Public Health. 2026 Apr 15;26(1):1556. doi: 10.1186/s12889-026-27366-5. PMID- 41987167 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Apr 15 TI - Admission Physiology Appeared More Informative Than Small-for-Gestational-Age Status for Predicting Severe In-Hospital Disposition in Preterm Infants Born at 28-36 Weeks: A Retrospective Single-Center NICU Cohort Study. LID - 10.1186/s12887-026-06825-3 [doi] LID - 493 AB - BACKGROUND: Whether small for gestational age adds prognostic information after NICU admission physiology is known remains uncertain in preterm infants. This distinction is clinically important because SGA is an anthropometric birth-size classification rather than, by itself, a diagnosis of fetal growth restriction. METHODS: We conducted a retrospective cohort study of 270 singleton infants born at 28 to 36 weeks' gestation and admitted to a tertiary NICU in Mashhad, Iran, during 2022 to 2023. SGA was defined using INTERGROWTH-21st standards. The primary endpoint was severe unfavorable disposition, defined as transfer to another facility or in-hospital death versus healthy discharge, with discharge against medical advice excluded by endpoint definition. We compared prespecified binary logistic models containing gestational age and SGA alone or combined with admission physiologic variables, and internally validated the binary models using 1000 bootstrap resamples. A secondary logistic model described admission features associated with SGA status. RESULTS: Seventy-eight infants (28.9%) were classified as SGA. Compared with AGA infants, SGA infants had lower platelet counts, lower red blood cell counts, higher venous PO2 values, and longer hospital stay. In the secondary SGA model, lower platelets and lower red blood cell counts were independently associated with SGA status. For the primary endpoint, 208 infants were eligible, including 31 transfer or death events. A model containing gestational age, log-transformed C-reactive protein, and venous pH showed better fit and discrimination than the gestational age plus SGA model, with optimism-corrected area under the curve 0.78, Brier score 0.11, and calibration slope 0.92. Adding SGA did not improve fit or discrimination, with likelihood-ratio p = 0.841 and adjusted OR 1.10, 95% CI 0.43 to 2.80. Replacing binary SGA with birth-weight z score also did not improve the model. When discharge against medical advice was included in a broader nonhealthy composite, discrimination fell substantially. CONCLUSION: In this single-center cohort of infants born at 28-36 weeks and admitted to a tertiary NICU in Mashhad, SGA as an anthropometric birth-size classification was associated with a distinct admission hematologic profile and longer hospital stay, but it did not improve prediction of severe hospital disposition after gestational age, admission venous pH, and CRP were considered. For this short-term disposition endpoint in this setting, admission physiology appeared more informative than birth-size category. These findings are hypothesis-generating, context-specific, and should not be extrapolated to longer-term outcomes or other NICU settings without external validation. FAU - Ghorooneh, Zeinab AU - Ghorooneh Z AD - Neonatal Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Mohammadzadeh, Ashraf AU - Mohammadzadeh A AD - Neonatal Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Farhat, Ahmad Shah AU - Farhat AS AD - Neonatal Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Daei, Nafiseh AU - Daei N AD - Neonatal Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Khodashenas, Ezzat AU - Khodashenas E AUID- ORCID: 0000-0002-8535-5307 AD - Neonatal Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. KhodashenasE@mums.ac.ir. LA - eng PT - Journal Article DEP - 20260415 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Infant, Newborn MH - Retrospective Studies MH - *Infant, Small for Gestational Age MH - *Intensive Care Units, Neonatal MH - Female MH - *Infant, Premature/physiology MH - Male MH - Gestational Age MH - Logistic Models MH - Length of Stay/statistics & numerical data MH - Prognosis MH - Hospital Mortality MH - *Patient Admission PMC - PMC13214418 OTO - NOTNLM OT - Intensive care units, neonatal OT - Length of stay OT - Premature OT - Prognosis OT - Small for gestational age COIS- Declarations. Ethics approval and consent to participate: This retrospective cohort study was approved by the Research Ethics Committee of Mashhad University of Medical Sciences (approval code: IR.MUMS.MEDICAL.REC.1401.257). The study was conducted in accordance with the Declaration of Helsinki and its later amendments. Because this study used de-identified routinely collected clinical data, involved no direct contact with participants, and introduced no study-specific intervention, the requirement for informed consent to participate from the infants' parents or legal guardians was waived by the Research Ethics Committee of Mashhad University of Medical Sciences. Consent for publication: Not applicable. This manuscript contains no identifiable individual person's data, images, or videos. Competing interests: The authors declare no competing interests. EDAT- 2026/04/16 13:09 MHDA- 2026/06/28 04:09 PMCR- 2026/04/15 CRDT- 2026/04/16 01:10 PHST- 2026/02/09 00:00 [received] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/06/28 04:09 [medline] PHST- 2026/04/16 13:09 [pubmed] PHST- 2026/04/16 01:10 [entrez] PHST- 2026/04/15 00:00 [pmc-release] AID - 10.1186/s12887-026-06825-3 [pii] AID - 6825 [pii] AID - 10.1186/s12887-026-06825-3 [doi] PST - epublish SO - BMC Pediatr. 2026 Apr 15;26(1):493. doi: 10.1186/s12887-026-06825-3. PMID- 41987152 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Apr 15 TI - The impact of physical activity on the psychological wellbeing and study abroad satisfaction of Chinese international students in a cross-cultural context. LID - 10.1186/s12889-026-27280-w [doi] LID - 1689 AB - PURPOSE: As the largest source country for international students, Chinese students often encounter challenges related to mental health and study abroad satisfaction during the process of cross-cultural adaptation. While physical activity is generally considered related to mental health, its potential mechanisms and contextual moderating factors have not been systematically studied. This study aims to explore the relationship between physical activity, mental health, and study abroad satisfaction, and to examine the moderating role of digital social media use. METHODS: A cross-sectional survey was conducted among 589 Chinese international students from nine countries. Ten validated scales were used to assess physical activity level, psychological wellbeing, study abroad satisfaction, and related psychosocial mechanisms. Structural equation modeling and the PROCESS macro were employed to test chain mediation and moderation effects. RESULTS: There is a significant positive association between physical activity and mental health. The study identified two chain mediation relationships: (1) social interaction competence --> emotion regulation ability --> positive coping strategies; (2) body image satisfaction --> cultural adaptation level --> social support level. In addition, a significant relationship exists between mental health and study abroad satisfaction. Moderation analysis indicates that digital social media use is related to the positive association between physical activity and mental health. CONCLUSIONS: Physical activity is positively associated with the mental health of Chinese international students and is related to higher study abroad satisfaction through dual psychosocial pathways. The use of digital social media appears to play a positive moderating role in this process, suggesting that cross-cultural interventions may achieve better outcomes by combining physical activity with appropriate digital support strategies. CI - (c) 2026. The Author(s). FAU - Liu, Zhaoyu AU - Liu Z AD - Department of Sport & Healthcare, Namseoul University, Cheonan, 31020, Korea. zhaoyuliu618@gmail.com. FAU - Quan, Qingyun AU - Quan Q AD - Sports Medicine Laboratory, Korea National Sport University, Seoul, 05541, Korea. FAU - Long, Biao AU - Long B AD - Department of Sport & Healthcare, Namseoul University, Cheonan, 31020, Korea. FAU - Kim, Soohyun AU - Kim S AD - Department of Sport & Healthcare, Namseoul University, Cheonan, 31020, Korea. shkim001@nsu.ac.kr. LA - eng SI - figshare/figshare.30074896 PT - Journal Article DEP - 20260415 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - Chinese people SB - IM MH - Humans MH - *Psychological Well-Being MH - *Personal Satisfaction MH - Female MH - *Exercise/psychology MH - *Students/psychology/statistics & numerical data MH - Cross-Sectional Studies MH - China MH - Male MH - Young Adult MH - *Cross-Cultural Comparison MH - Adolescent MH - Adult MH - Surveys and Questionnaires MH - Social Media/statistics & numerical data MH - *Mental Health MH - East Asian People PMC - PMC13200439 OTO - NOTNLM OT - Chain mediation OT - Chinese international students OT - Digital social media use OT - Physical activity OT - Psychological wellbeing OT - Study abroad satisfaction COIS- Declarations. Ethics approval and consent to participate: All procedures in this study adhered to the ethical standards of the 1964 Declaration of Helsinki and its later amendments. The study was reviewed by the Institutional Review Board of Namseoul University and was granted exemption from full ethical approval, in accordance with national regulations. Informed consent was obtained from all participants. The questionnaire used in this study was adapted from previously validated instruments rather than newly developed. An English version of the adapted items has been uploaded as Supplementary Material S1. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/16 13:09 MHDA- 2026/05/25 06:31 PMCR- 2026/04/15 CRDT- 2026/04/16 01:09 PHST- 2025/09/10 00:00 [received] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/05/25 06:31 [medline] PHST- 2026/04/16 13:09 [pubmed] PHST- 2026/04/16 01:09 [entrez] PHST- 2026/04/15 00:00 [pmc-release] AID - 10.1186/s12889-026-27280-w [pii] AID - 27280 [pii] AID - 10.1186/s12889-026-27280-w [doi] PST - epublish SO - BMC Public Health. 2026 Apr 15;26(1):1689. doi: 10.1186/s12889-026-27280-w. PMID- 41986943 OWN - NLM STAT- MEDLINE DCOM- 20261021 LR - 20261021 IS - 2154-4700 (Electronic) IS - 1933-8244 (Linking) VI - 81 IP - 5-6 DP - 2026 TI - Associations between ultra-processed food consumption, work-related and mental health outcomes among staff at a private hospital in Turkiye. PG - 113-125 LID - 10.1080/19338244.2026.2654391 [doi] AB - This study explored the relationship between ultra-processed food (UPF) consumption and work performance, sleep quality, and mental well-being among hospital staff in Turkiye using a cross-sectional design. A total of 150 participants aged 18-65 were included. Data were collected using validated instruments: the Pittsburgh Sleep Quality Index (PSQI), the Warwick-Edinburgh Mental Well-Being Scale (WEMWBS), and the Job Performance Scale (JPS). Participants were divided into three groups based on their daily UPF consumption: low (<306.97 g/day), moderate (306.97-778.57 g/day), and high (>778.57 g/day). The mean UPF intake was 507.3 +/- 288.1 g/day. Overall, 51.3% of participants had poor sleep quality. Mean PSQI scores were 5.05 +/- 2.12 in the low UPF group and 5.48 +/- 3.21 in the high group (p = 0.360). Participants in the high UPF group had a mean WEMWBS score of 60.04 +/- 9.45, compared to 56.10 +/- 7.02 in the low UPF group (p = 0.019). The high UPF group showed higher job performance scores (mean = 50.44 +/- 4.93) compared to the moderate group (mean = 46.23 +/- 7.27) and the low group (mean = 46.07 +/- 7.25) (p = 0.016). While the findings suggest a positive association between UPF consumption and both mental well-being and job performance, these results should be interpreted with caution due to the cross-sectional nature of the study. Further research is needed to explore long-term effects and underlying mechanisms. Additionally, future research could examine whether short-term improvements in mood or energy from UPF consumption translate into long-term health tradeoffs. FAU - Yenice Kartal, Esma AU - Yenice Kartal E AUID- ORCID: 0009-0006-5026-3011 AD - Institute of Health Science, Department of Nutrition and Dietetics, Uskudar University, Istanbul, Turkiye. FAU - Yilmaz, Haci Omer AU - Yilmaz HO AUID- ORCID: 0000-0003-4597-7758 AD - Faculty of Health Science, Department of Nutrition and Dietetics, Bandirma Onyedi Eylul University, Balikesir, Turkiye. LA - eng PT - Journal Article DEP - 20260415 PL - United States TA - Arch Environ Occup Health JT - Archives of environmental & occupational health JID - 101282564 SB - IM MH - *Fast Foods/statistics & numerical data MH - *Mental Health/statistics & numerical data MH - *Personnel, Hospital/psychology/statistics & numerical data MH - Psychological Well-Being MH - Hospitals, Private/statistics & numerical data MH - Sleep Quality MH - *Work Performance/statistics & numerical data MH - *Feeding Behavior MH - Cross-Sectional Studies MH - Turkey MH - Surveys and Questionnaires/statistics & numerical data MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged OTO - NOTNLM OT - Hospital staff OT - Ultra-processed foods OT - job performance OT - mental health OT - sleep quality EDAT- 2026/04/16 13:09 MHDA- 2026/05/31 18:32 CRDT- 2026/04/16 00:13 PHST- 2026/05/31 18:32 [medline] PHST- 2026/04/16 13:09 [pubmed] PHST- 2026/04/16 00:13 [entrez] AID - 10.1080/19338244.2026.2654391 [doi] PST - ppublish SO - Arch Environ Occup Health. 2026;81(5-6):113-125. doi: 10.1080/19338244.2026.2654391. Epub 2026 Apr 15. PMID- 41986183 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 0035-3787 (Print) IS - 0035-3787 (Linking) VI - 182 IP - 5 DP - 2026 May TI - Non-infectious environmental risk factors of multiple sclerosis: Mechanisms and intervention windows for prevention. PG - 455-466 LID - S0035-3787(26)00504-7 [pii] LID - 10.1016/j.neurol.2026.03.010 [doi] AB - The trajectory of multiple sclerosis (MS) is shaped by complex interactions between genetic susceptibility and environmental factors. This review examines modifiable non-infectious determinants across the life course and proposes integrated prevention strategies. Key factors include vitamin D deficiency, low UV exposure, smoking, adolescent obesity, air pollution, and chemical environmental exposures. Mendelian randomization studies support the causality of several determinants, particularly low vitamin D and high BMI. Adolescence emerges as a critical susceptibility window where the maturing immune system is uniquely sensitive to metabolic and environmental triggers. Among validated interventions, vitamin D supplementation stands out for its ability to reduce disease activity in early MS. Effective prevention requires both individual actions and structural public health policies, such as air quality regulations and urban "walkability". Future efforts should prioritize multimodal strategies targeting high-risk youths through the educational system (physical activity, weight management, and smoking prevention). These holistic approaches offer broad-spectrum benefits, reducing the burden of MS while preventing comorbidities, including cardiovascular, metabolic but also cancer. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Masson SAS.. All rights reserved. FAU - Rival, M AU - Rival M AD - Inserm, Service de Neurologie, CNRS, IGF, Universite de Montpellier, CHU de Nimes, Nimes, France. FAU - Thouvenot, E AU - Thouvenot E AD - Inserm, Service de Neurologie, CNRS, IGF, Universite de Montpellier, CHU de Nimes, Nimes, France. Electronic address: eric.thouvenot@chu-nimes.fr. LA - eng PT - Journal Article PT - Review DEP - 20260414 PL - France TA - Rev Neurol (Paris) JT - Revue neurologique JID - 2984779R RN - 1406-16-2 (Vitamin D) SB - IM MH - Humans MH - *Multiple Sclerosis/prevention & control/etiology/epidemiology MH - Risk Factors MH - *Environmental Exposure/adverse effects MH - Vitamin D Deficiency/complications MH - Obesity/complications MH - Vitamin D MH - Smoking/adverse effects OTO - NOTNLM OT - Environmental risk factors OT - Multiple sclerosis OT - Obesity OT - Smoking OT - Vitamin D COIS- Disclosure of interest The authors declare that they have no competing interest. EDAT- 2026/04/16 00:32 MHDA- 2026/05/13 00:29 CRDT- 2026/04/15 21:54 PHST- 2026/02/14 00:00 [received] PHST- 2026/03/15 00:00 [revised] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/05/13 00:29 [medline] PHST- 2026/04/16 00:32 [pubmed] PHST- 2026/04/15 21:54 [entrez] AID - S0035-3787(26)00504-7 [pii] AID - 10.1016/j.neurol.2026.03.010 [doi] PST - ppublish SO - Rev Neurol (Paris). 2026 May;182(5):455-466. doi: 10.1016/j.neurol.2026.03.010. Epub 2026 Apr 14. PMID- 41986110 OWN - NLM STAT- Publisher LR - 20260415 IS - 2047-9956 (Print) IS - 2047-9956 (Linking) DP - 2026 Apr 15 TI - Method for analysing individualised parenteral nutrition prescriptions for substitution with a market authorised or standardised parenteral nutrition formula. LID - ejhpharm-2025-004749 [pii] LID - 10.1136/ejhpharm-2025-004749 [doi] AB - OBJECTIVE: This study aims to develop a method and a tool to determine whether an individualised parenteral nutrition (PN) prescription for premature newborns can be replaced by a market authorised or standardised PN formula. METHODS: We reviewed available PN formulas in France for premature newborns, including market authorised drugs and standardised formulas from our hospital and those proposed for the French national formulary. We collected data on 280 individualised PN prescriptions produced in our hospital over a 4 month period. Critical nutritional parameters for premature newborns-administered volume, amino acids, carbohydrates, sodium, potassium, calcium, and phosphorus-were identified based on European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) guidelines. RESULTS: An algorithm was created to compare individualised PN prescriptions to available formulas, proposing an alternative if all critical nutritional intakes did not deviate by more than 15% from the prescribed intakes. The algorithm was then applied to the extracted prescriptions. Out of 280 individualised PN prescriptions, only 23 (5%) concerning six patients had a suitable alternative. The formulas most frequently identified as alternatives were Prem2C (17 occurrences) and Premend (seven occurrences). CONCLUSION: The developed algorithm can be used to audit prescription practices or as a routine tool for pharmaceutical validation. Integrating such a tool into prescription software could provide real-time support for prescribers and pharmacists. The results confirm that while some individualised PN prescriptions can be substituted, individualised PN remains essential for meeting the complex and specific nutritional needs of premature newborns in paediatric intensive care units. CI - (c) European Association of Hospital Pharmacists 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Robin, Paul AU - Robin P AUID- ORCID: 0009-0004-7402-6411 AD - Pharmaceutical Technology Department, University Hospital Centre Poitiers, Poitiers, France paul.robin@chu-poitiers.fr. FAU - Delrieu, Jeremy AU - Delrieu J AD - Pharmaceutical Technology Department, University Hospital Centre Poitiers, Poitiers, France. LA - eng PT - Journal Article DEP - 20260415 PL - England TA - Eur J Hosp Pharm JT - European journal of hospital pharmacy : science and practice JID - 101578294 SB - IM OTO - NOTNLM OT - Automation OT - Drug Compounding OT - Information Technology OT - Nutritional Support OT - PEDIATRICS COIS- Competing interests: None declared. EDAT- 2026/04/16 00:32 MHDA- 2026/04/16 00:32 CRDT- 2026/04/15 21:32 PHST- 2025/09/04 00:00 [received] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/04/16 00:32 [medline] PHST- 2026/04/16 00:32 [pubmed] PHST- 2026/04/15 21:32 [entrez] AID - ejhpharm-2025-004749 [pii] AID - 10.1136/ejhpharm-2025-004749 [doi] PST - aheadofprint SO - Eur J Hosp Pharm. 2026 Apr 15:ejhpharm-2025-004749. doi: 10.1136/ejhpharm-2025-004749. PMID- 41985778 OWN - NLM STAT- MEDLINE DCOM- 20260819 LR - 20260819 IS - 1097-6868 (Electronic) IS - 0002-9378 (Linking) VI - 235 IP - 3 DP - 2026 Sep TI - Screening for large-for-gestational-age neonates at term: evidence of a labeling effect and increased intervention without neonatal benefit. PG - 686-698 LID - S0002-9378(26)00195-X [pii] LID - 10.1016/j.ajog.2026.04.015 [doi] AB - BACKGROUND: Routine third-trimester ultrasound screening for suspected large-for-gestational-age (LGA) and macrosomic fetuses is increasingly used to guide obstetric management and reduce delivery-related morbidity. However, ultrasound estimation of fetal weight at term has limited diagnostic accuracy, and evidence supporting interventions to reduce morbidity in large fetuses remains limited. Together, these uncertainties raise questions regarding the benefit of routine ultrasound screening for fetal largeness at term. OBJECTIVE: To evaluate the diagnostic accuracy of routine third-trimester ultrasound for detecting large-for-gestational-age and macrosomic neonates at term and the impact of inaccurate prenatal diagnosis on obstetric management and perinatal outcomes. STUDY DESIGN: A retrospective cohort study of 21,743 singleton pregnancies undergoing routine 35 to 37 weeks of ultrasound at a tertiary referral center. Pregnancies with major fetal anomalies, genetic abnormalities, or missing outcome data were excluded. Estimated fetal weight >/=90th centile defined screen-positive status; birthweight >/=90th centile and >4000 g defined large-for-gestational-age and macrosomia at birth, respectively. Study outcomes included mode of delivery and composite adverse perinatal outcomes comprising maternal and neonatal outcomes. Composite adverse maternal outcomes included postpartum hemorrhage, high dependency or intensive care unit admission, obstetric anal sphincter injury, and intrapartum cesarean delivery, while composite adverse neonatal outcomes included neonatal intensive care unit admission >48 hours, continuous positive airway pressure support, mechanical ventilation, hypoxic-ischemic encephalopathy, intraventricular hemorrhage, respiratory distress syndrome, seizures, hypoglycemia, transient tachypnea of the newborn, meconium aspiration syndrome, and death. Adjusted relative risks with 95% confidence intervals were estimated using modified Poisson regression, adjusting for maternal and pregnancy characteristics. Diagnostic performance measures, including sensitivity, specificity, positive predictive value, negative predictive value, positive and negative likelihood ratios, and 95% confidence intervals, were calculated. The interval between the index test and reference standard was the time from ultrasound to delivery. Clinicians were aware of ultrasound findings, which informed counseling and management. Results are reported as adjusted relative risks with 95% confidence intervals. RESULTS: Ultrasound screening showed a sensitivity of 34.9% (33.2-36.6) for large-for-gestational-age and 35.6% (33.5-37.9) for macrosomia, with specificity of 97.4% (97.2-97.6) and 95.6% (95.3-95.9), respectively. Screen-positive pregnancies were significantly less likely to attempt labor (adjusted relative risk, 0.87; 95% confidence interval, 0.84-0.90; P<.001) and more likely to undergo intrapartum cesarean delivery (adjusted relative risk, 1.47; 95% confidence interval, 1.30-1.67; P<.001), with higher risks of composite adverse maternal (adjusted relative risk, 1.43; 95% confidence interval, 1.32-1.55; P<.001) and neonatal (adjusted relative risk, 2.37; 95% confidence interval, 1.85-3.05; P<.001) outcomes. Compared to true-positive cases, false-negative cases were associated with significantly lower rates of induction of labor (adjusted relative risk, 0.74; 95% confidence interval, 0.68-0.81; P<.001), intrapartum cesarean delivery (adjusted relative risk, 0.70; 95% confidence interval, 0.59-0.83; P<.001), and composite adverse maternal outcomes (adjusted relative risk, 0.87; 95% confidence interval, 0.77-0.98; P<.032), with no increased risk of adverse neonatal outcomes (adjusted relative risk, 0.77; 95% confidence interval, 0.56-1.06; P=.12). Compared to true-negative cases, false-positive cases experienced higher rates of operative vaginal delivery (adjusted relative risk, 1.29; 95% confidence interval, 1.07-1.57; P<.001), intrapartum cesarean delivery (adjusted relative risk, 1.25; 95% confidence interval, 1.0-1.55; P=.045), and composite adverse maternal outcomes (adjusted relative risk, 1.28; 95% confidence interval, 1.11-1.48; P<.001) with no difference in the risk of adverse neonatal outcomes (adjusted relative risk, 1.35; 95% confidence interval, 0.72-2.53; P=.347) CONCLUSION: Routine third-trimester ultrasound screening for suspected large-for-gestational-age and macrosomia demonstrates limited diagnostic performance and appears to generate a labeling effect, whereby obstetric intervention and some adverse outcomes may be influenced more by suspected large-for-gestational-age status than by fetal size itself. These findings raise questions about the benefit of universal large-for-gestational-age screening at term and support consideration of more individualized, risk-based approaches to late-pregnancy assessment. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Lopian, Miriam AU - Lopian M AD - Fetal Medicine, St George's University Hospitals NHS Foundation Trust, London, United Kingdom; Department of Obstetrics and Gynecology, Mayanei Hayeshua Medical Centre, Bnei Brak, Israel Tel Aviv, Israel. FAU - Ulusoy, Can Ozan AU - Ulusoy CO AD - Ministry of Health, Etlik City Hospital, Perinatology Department, Ankara, Turkey. FAU - Mohamed, Doaa AU - Mohamed D AD - Fetal Medicine, St George's University Hospitals NHS Foundation Trust, London, United Kingdom. FAU - Segal, Ella AU - Segal E AD - Ministry of Health, Etlik City Hospital, Perinatology Department, Ankara, Turkey; Gray School of Medicine, Tel Aviv Univerisity, Tel Aviv, Israel. FAU - Khalil, Asma AU - Khalil A AD - Fetal Medicine, St George's University Hospitals NHS Foundation Trust, London, United Kingdom; Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, City St George's University of London, London, United Kingdom; Fetal Medicine Unit, Liverpool Women's Hospital, Liverpool, United Kingdom. Electronic address: akhalil@sgul.ac.uk. LA - eng PT - Journal Article DEP - 20260414 PL - United States TA - Am J Obstet Gynecol JT - American journal of obstetrics and gynecology JID - 0370476 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Retrospective Studies MH - *Fetal Macrosomia/diagnostic imaging/epidemiology MH - Infant, Newborn MH - Infant, Large for Gestational Age MH - *Ultrasonography, Prenatal MH - Adult MH - Pregnancy Trimester, Third MH - Fetal Weight MH - Hypoglycemia/epidemiology MH - Cesarean Section/statistics & numerical data MH - Gestational Age MH - Meconium Aspiration Syndrome/epidemiology OTO - NOTNLM OT - abdominal circumference OT - estimated fetal weight OT - fetal biometry OT - large for gestational age OT - macrosomia OT - screening OT - third-trimester ultrasound EDAT- 2026/04/16 13:09 MHDA- 2026/08/19 23:42 CRDT- 2026/04/15 19:40 PHST- 2025/12/01 00:00 [received] PHST- 2026/04/05 00:00 [revised] PHST- 2026/04/08 00:00 [accepted] PHST- 2026/08/19 23:42 [medline] PHST- 2026/04/16 13:09 [pubmed] PHST- 2026/04/15 19:40 [entrez] AID - S0002-9378(26)00195-X [pii] AID - 10.1016/j.ajog.2026.04.015 [doi] PST - ppublish SO - Am J Obstet Gynecol. 2026 Sep;235(3):686-698. doi: 10.1016/j.ajog.2026.04.015. Epub 2026 Apr 14. PMID- 41985735 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 1879-176X (Electronic) IS - 0300-5712 (Linking) VI - 170 DP - 2026 Jul TI - AI-based classification of pediatric sagittal skeletal patterns using multi-view facial photographs. PG - 106697 LID - S0300-5712(26)00368-4 [pii] LID - 10.1016/j.jdent.2026.106697 [doi] AB - OBJECTIVE: The increasing global demand to assess pediatric skeletal malocclusions poses a growing challenge, as current screening methods are dependent on availability of orthodontists and X-rays, which limits accessibility. This study aimed to develop and validate an artificial intelligence (AI) model based on facial photographs to predict pediatric sagittal skeletal pattern classifications and to explore its feasibility for radiation-free early screening of pediatric skeletal malocclusion. METHODS: Facial photographs and lateral cephalograms were collected retrospectively from a cohort of 2033 pediatric patients at a stomatology hospital between 2013 and 2023. The dataset was divided into a training (n = 1789) and an independent test set (n = 244). Data were annotated, preprocessed, and augmented. Six backbones were compared, and ConvNeXt-T was selected as the optimal backbone. An innovative primary- auxiliary feature fusion strategy was adopted to identify the primary feature inputs and we first trained four single-view models. Subsequently, the primary and auxiliary features from other views were fused to construct four multi-view feature fusion models. Performance was evaluated by using five-fold cross-validation, with Grad-CAM visualizing key feature areas. Finally, the optimal model was clinically validated against practicing orthodontists on the independent test set. RESULTS: The 90 degrees profile model achieved the highest accuracy of 86.36% among all single-view models. The optimal multi-view model further improved the accuracy to 88.30% (recall=81.79%, specificity=91.22%). Using the independent test set, the model's agreement with the gold standard was 9.25% higher than junior level orthodontists and 7.43% higher than intermediate orthodontists (both P < 0.05), and closely aligns with senior professionals (difference: 2.70%). Grad-CAM confirmed focus on the nasolabial and chin contour regions. CONCLUSIONS: An innovative method was successfully established to predict pediatric sagittal skeletal patterns with high accuracy (>88%) using multi-dimensional facial characteristics. This lays the groundwork for a non-clinical, photographic screening approach for identify pediatric skeletal malocclusions. CLINICAL SIGNIFICANCE: This method provides a feasible, radiation-free solution for early large-scale screening in non-clinical settings, supporting initial referral decisions while promoting early interventions and stratified management of children's oral health. It should be emphasized that this tool is intended primarily to assist screenings and referrals, rather than replacing the essential work of expert professionals. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Peng, Ying AU - Peng Y AD - Guangxi University, School of Computer, Electronics and Information, Nanning, 530004, China. FAU - Nan, Lan AU - Nan L AD - Guangxi Medical University College of Stomatology, Nanning 530021, China. FAU - Chen, Wenkang AU - Chen W AD - Guangxi University, School of Electrical Engineering, Nanning, 530004, China. FAU - Zeng, Xiaojuan AU - Zeng X AD - Guangxi Medical University College of Stomatology, Nanning 530021, China. FAU - Tang, Min AU - Tang M AD - Guangxi Medical University College of Stomatology, Nanning 530021, China; Guangxi Clinical Research Center for Craniofacial Deformity, Nanning 530021, China. Electronic address: KQ100895@sr.gxmu.edu.cn. FAU - Zhang, Xuejun AU - Zhang X AD - Guangxi University, School of Computer, Electronics and Information, Nanning, 530004, China. Electronic address: xjzhang@gxu.edu.cn. LA - eng PT - Journal Article DEP - 20260413 PL - England TA - J Dent JT - Journal of dentistry JID - 0354422 SB - IM MH - Humans MH - *Artificial Intelligence MH - Child MH - Retrospective Studies MH - *Photography/methods MH - *Malocclusion/diagnosis/diagnostic imaging/classification MH - Cephalometry/methods MH - Female MH - Male MH - *Face/anatomy & histology/diagnostic imaging OTO - NOTNLM OT - Convolutional neural networks OT - Facial photographs OT - Multi-view feature fusion OT - Pediatrics OT - Sagittal skeletal pattern OT - Screening OT - Skeletal malocclusion COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/16 13:09 MHDA- 2026/05/09 00:34 CRDT- 2026/04/15 19:39 PHST- 2025/12/07 00:00 [received] PHST- 2026/04/02 00:00 [revised] PHST- 2026/04/12 00:00 [accepted] PHST- 2026/05/09 00:34 [medline] PHST- 2026/04/16 13:09 [pubmed] PHST- 2026/04/15 19:39 [entrez] AID - S0300-5712(26)00368-4 [pii] AID - 10.1016/j.jdent.2026.106697 [doi] PST - ppublish SO - J Dent. 2026 Jul;170:106697. doi: 10.1016/j.jdent.2026.106697. Epub 2026 Apr 13. PMID- 41984914 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 4 DP - 2026 TI - Validating self-reported exclusive breastfeeding in Eswatini using stable isotope techniques. PG - e0346799 LID - 10.1371/journal.pone.0346799 [doi] LID - e0346799 AB - Exclusive breastfeeding (EBF) prevalence at the population level is typically assessed through maternal or caregiver reports, which are prone to recall and social desirability biases. The deuterium oxide dose-to-mother (DTM) technique offers an objective alternative by administering a small amount of deuterium-labeled water to lactating mothers. This study compared the prevalence of EBF from maternal recall versus the DTM method in Eswatini and evaluated the strengths and limitations of both approaches in assessing infant feeding practices linked to malnutrition. A total of 102 mother-infant pairs were recruited from three regional hospitals and three health centers in Eswatini. EBF was assessed by maternal recall using the WHO 24-hour infant feeding recall method and objectively measured using the DTM stable isotope technique at three infant age intervals: 6 weeks to 2.4 months (n = 26), 2.5 to 4.0 months (n = 43), and 4.1 to 5.5 months (n = 33). Two cutoff values defined EBF status via the stable isotope method. Agreement between maternal recall and DTM measurements was analyzed using Kappa statistics. Maternal recall consistently overestimated EBF across all time points compared to the DTM method. Using Model 1 cutoffs, prevalences of EBF by maternal recall vs. DTM were 100% vs. 50% (/= 500 IU/L, serum phosphorus < 4.5 mg/dL, and tubular phosphate reabsorption > 95% at 4-6 weeks of life. Fractures were confirmed by X-ray. Multivariable logistic regression and ROC curve analyses were used to identify independent predictors and assess discriminative performance. RESULTS: Among the 413 very low birth weight infants included in the study, biochemical MBD was identified in 82 (19.8%); the overall fracture rate was 5.3% (22/413), whereas it was 26.8% (22/82) among infants with biochemical MBD. Male sex, lower 5-minute Apgar scores, need for resuscitation, caffeine administration, bronchopulmonary dysplasia, patent ductus arteriosus, postnatal steroid exposure, cholestasis, delayed attainment of full enteral feeding, prolonged total parenteral nutrition, and >/= 3 red blood cell transfusions were significantly associated with biochemical MBD. Multivariate analysis identified male sex (OR 2.29; 95% CI: 1.317-3.970; p = 0.003), parenteral nutrition (PN) duration (OR 1.019 per day; 95% CI: 1.007-1.032; p = 0.003), and >/= 3 red blood cell transfusions (OR 3.96; 95% CI: 2.193-7.149; p < 0.001) as independent predictors of biochemical MBD. The regression model demonstrated good calibration (Hosmer-Lemeshow p = 0.790) and acceptable discriminative ability (AUC 0.788; 95% CI: 0.733-0.844). Infants with biochemical MBD had significantly elevated alkaline phosphatase (ALP) levels and lower serum phosphate concentrations (698 vs. 392 U/L and 3.63 vs. 5.4 mg/dL, respectively; p < 0.001), while serum calcium levels were similar. ROC analysis indicated that a PN duration exceeding 19.5 days (AUC 0.730; 95% CI: 0.671-0.789; p < 0.001) was a strong predictor of biochemical MBD. Comparisons between infants with and without fractures revealed no significant differences in ALP, phosphate, or tubular reabsorption of phosphate levels; however, serum calcium levels were significantly lower in infants who developed fractures (9.1 vs. 9.5 mg/dL; p = 0.022). CONCLUSION: A PN duration >/= 19.5 days is an early, clinically useful predictor of biochemical MBD in preterm infants and is associated with fracture risk. Male sex, prolonged PN, and multiple erythrocyte transfusions are independent predictors of biochemical MBD in VLBW infants. Lower serum calcium in infants with fractures suggests a more severe disease course. Early identification of high-risk infants may allow timely preventive interventions. FAU - Tunc, Gaffari AU - Tunc G AUID- ORCID: 0000-0001-7837-3948 AD - Department of Neonatology, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey. dr.gaffaritunc@gmail.com. FAU - Guney Varal, Ipek AU - Guney Varal I AUID- ORCID: 0000-0002-3298-066X AD - Bursa Faculty of Medicine, Department of Neonatology, University of Health Sciences, Bursa, Turkey. FAU - Oren, Ayse AU - Oren A AUID- ORCID: 0000-0002-0864-4244 AD - Department of Neonatology, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey. FAU - Ulker, Dilara AU - Ulker D AUID- ORCID: 0000-0002-3951-5234 AD - Department of Pediatrics, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey. FAU - Denkboy Ongen, Yasemin AU - Denkboy Ongen Y AUID- ORCID: 0000-0002-5657-4260 AD - School of Medicine, Department of Pediatric Endocrinology, Bursa Uludag University, Bursa, Turkey. FAU - Bagci, Onur AU - Bagci O AUID- ORCID: 0000-0001-9308-9806 AD - Department of Neonatology, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkey. LA - eng PT - Journal Article DEP - 20260414 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 RN - 0 (Biomarkers) RN - EC 3.1.3.1 (Alkaline Phosphatase) RN - 27YLU75U4W (Phosphorus) SB - IM MH - Humans MH - Male MH - Infant, Newborn MH - Female MH - *Bone Diseases, Metabolic/complications/blood/diagnosis/epidemiology MH - *Fractures, Bone/etiology/epidemiology MH - Retrospective Studies MH - Risk Factors MH - Biomarkers/blood MH - Infant, Very Low Birth Weight MH - Infant, Premature MH - *Infant, Premature, Diseases/blood/epidemiology/diagnosis MH - Alkaline Phosphatase/blood MH - Phosphorus/blood MH - ROC Curve MH - Logistic Models PMC - PMC13202942 OTO - NOTNLM OT - Fracture risk OT - Metabolic bone disease OT - PN OT - Preterm infants OT - Red blood cell transfusion OT - VLBW COIS- Declarations. Ethics approval and consent to participate: The Bursa Yuksek Ihtisas Training and Research Hospital Ethical Committee approved the study on 06.11.2024 as approval number 2024-TBEK 2024/11-08. The study was conducted following the Declaration of Helsinki. Due to the retrospective design of the study, ethical committee approval was considered sufficient, and written informed consent was not required. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/15 00:31 MHDA- 2026/06/27 22:35 PMCR- 2026/04/14 CRDT- 2026/04/14 23:40 PHST- 2026/01/17 00:00 [received] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/06/27 22:35 [medline] PHST- 2026/04/15 00:31 [pubmed] PHST- 2026/04/14 23:40 [entrez] PHST- 2026/04/14 00:00 [pmc-release] AID - 10.1186/s12887-026-06824-4 [pii] AID - 6824 [pii] AID - 10.1186/s12887-026-06824-4 [doi] PST - epublish SO - BMC Pediatr. 2026 Apr 14;26(1):487. doi: 10.1186/s12887-026-06824-4. PMID- 41981408 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 27 IP - 1 DP - 2026 Apr 14 TI - Development of artificially intelligent tool for analysis and prediction of myopia progression among school-going children. LID - 10.1186/s13063-026-09648-w [doi] LID - 390 AB - BACKGROUND: Myopia is a growing public health concern among school-going children, with increased screen time and reduced outdoor activities contributing to its early onset and rapid progression. In India, the absence of a standardized, population-based dataset reflecting socio-economic and environmental diversity limits the development of accurate prediction tools. This study aims to design and validate an artificial intelligence (AI)-based model to analyze and predict myopia progression among children aged 6 to 18 years in urban and rural areas. METHODS: This is a prospective, community-based study conducted in two phases across five districts of Bhopal division, India. Phase one involves a cross-sectional survey of approximately 5,000 school children to collect demographic and ocular health data, including visual acuity, refractive error, axial length, corneal parameters, and lifestyle factors. In phase two, a longitudinal cohort comprising 10% of the phase one participants (balanced for existing and non-existing myopia cases) will be followed every 6 months over 2 years. Machine learning algorithms, including linear regression, support vector machines, XGBoost, and deep learning models such as convolutional neural networks, will be trained on this dataset. An AI-based mobile application will be developed to enable field-level prediction and screening. DISCUSSION: This study will generate the first large-scale Indian dataset on myopia progression among children, incorporating diverse socio-economic backgrounds. The validated AI model and mobile application will support early identification of at-risk children, optimize resource allocation, and inform national screening strategies. By integrating real-time data analytics with field-l. TRIAL REGISTRATION: CTRI/2025/07/091243. Registered on 21/07/2025. CI - (c) 2026. The Author(s). FAU - Singh, Priti AU - Singh P AD - All India Institute of Medical Sciences, Bhopal, India. priti.ophtho@aiimsbhopal.edu.in. FAU - Verma, Vidhya AU - Verma V AD - All India Institute of Medical Sciences, Bhopal, India. FAU - Karkhur, Samendra AU - Karkhur S FAU - Beri, Arushi AU - Beri A AD - All India Institute of Medical Sciences, Bhopal, India. FAU - Singhai, Jyoti AU - Singhai J AD - Department of Electronics and Communication Engineering, Maulana Azad National Institute of Technology, Bhopal, India. FAU - Agrawal, Dheraj Kumar AU - Agrawal DK AD - Department of Electronics and Communication Engineering, Maulana Azad National Institute of Technology, Bhopal, India. LA - eng GR - Dev/SG-11/2024(E OFFICE 220033/ICMR/ PT - Journal Article PT - Validation Study DEP - 20260414 PL - England TA - Trials JT - Trials JID - 101263253 SB - IM MH - Humans MH - Child MH - Prospective Studies MH - India/epidemiology MH - Disease Progression MH - *Myopia/diagnosis/physiopathology/epidemiology MH - Cross-Sectional Studies MH - Adolescent MH - Predictive Learning Models MH - *Artificial Intelligence MH - Prediction Algorithms MH - Predictive Value of Tests MH - Male MH - Female MH - Boosting Machine Learning Algorithms MH - Risk Factors MH - Machine Learning MH - Time Factors PMC - PMC13188629 OTO - NOTNLM OT - Artificial intelligence OT - Machine learning OT - Myopia progression OT - Predictive modeling OT - Public health ophthalmology OT - School children OT - Vision screening COIS- Declarations. Ethics approval and consent to participate 24: This study has received ethical approval from the Institutional Ethics Committee (IEC) of the All India Institute of Medical Sciences (AIIMS), Bhopal. IEC Approval Reference Number: AIIMS/IHEC-LOP/2025/IP003. A certified copy of the original approval letter and an English translation will be submitted as an additional file with this manuscript, as required by Trials. Written, informed consent to participate will be obtained from the parents or legal guardians of all school-going child participants. In addition, age-appropriate assent will be obtained from the children themselves, in accordance with national ethical guidelines and institutional policies. The study protocol adheres to the ethical principles outlined in the Declaration of Helsinki and complies with the Indian Council of Medical Research (ICMR) National Ethical Guidelines for Biomedical and Health Research Involving Human Participants (2017). Consent for publication 32: No identifiable individual-level information, images, or videos will be published as part of this study protocol. If such materials are included in future publications or reports, written informed consent for publication will be obtained from the individuals concerned or, in the case of minors, from their parents or legal guardians. A model informed consent form, child assent form, and associated participant information sheets have been developed in accordance with the guidelines of the Institutional Ethics Committee (IEC), AIIMS Bhopal, and are available in both English and Hindi. These documents will be provided to the journal editorial office upon request. Competing interests 28: The authors declare that they have no competing interests. EDAT- 2026/04/15 00:33 MHDA- 2026/05/20 06:31 PMCR- 2026/04/14 CRDT- 2026/04/14 23:34 PHST- 2025/07/22 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/05/20 06:31 [medline] PHST- 2026/04/15 00:33 [pubmed] PHST- 2026/04/14 23:34 [entrez] PHST- 2026/04/14 00:00 [pmc-release] AID - 10.1186/s13063-026-09648-w [pii] AID - 9648 [pii] AID - 10.1186/s13063-026-09648-w [doi] PST - epublish SO - Trials. 2026 Apr 14;27(1):390. doi: 10.1186/s13063-026-09648-w. PMID- 41981098 OWN - NLM STAT- Publisher LR - 20260414 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Apr 14 TI - Association between dietary patterns and cardiometabolic health in children: findings from the Childhood Obesity Risk Assessment Longitudinal Study (CORALS) cohort. LID - 10.1038/s41390-026-04889-6 [doi] AB - BACKGROUND: Dietary habits influence health from childhood, with effects that may persist throughout life. This study aimed to investigate the association between dietary patterns and cardiometabolic risk markers in early childhood. METHODS: A cross-sectional analysis was performed within the Childhood Obesity Risk Assessment Longitudinal Study (CORALS) cohort. Diet was assessed by a validated food frequency questionnaire. Dietary patterns were extracted using exploratory factor analysis. Cardiometabolic risk was analysed through internal z-scores, body mass index (BMIz), systolic blood pressure, HDL cholesterol (HDLz), triglycerides and HOMA-IR, and multi-adjusted linear regression models were performed. RESULTS: The analysis included 1426 participants (median age 4.95 years). Two dietary patterns (DPs) were identified: "Core-foods DP" (high in vegetables, fruits, nuts, legumes, fish and white meat) and "Poor-quality DP" (rich in flavoured dairy products, processed meat, pastries, sweets, snacks, precooked foods, other oils and soft drinks). Core-foods DP was inversely associated with BMIz (B = -0.07, p = 0.034), meanwhile the Poor-quality DP was directly associated with triglycerides (B = 0.09, p = 0.015) and higher overweight odds (OR:1.33; 95% CI:1.13-1.56), and inversely with HDLz (B = -0.08, p = 0.036). CONCLUSION: Poor-quality DP was directly associated with cardiometabolic risk markers in preschool-aged children, emphasizing the importance of diet in preventing the early onset of obesity and cardiometabolic disorders. IMPACT: This study highlights the impact of dietary patterns on cardiometabolic health in preschool children. A poor-quality dietary pattern is directly associated with BMI and triglycerides and inversely associated with HDL cholesterol, which may contribute to a worse cardiometabolic profile. In contrast, adherence to a core-foods pattern is inversely associated with BMI. These findings reinforce the importance of early nutrition education in preventing obesity and cardiometabolic disorders. This article provides evidence of diet-related metabolic risks in early life to limited existing literature and the need for interventions that promote healthier eating habits from an early age to improve long-term health outcomes. CI - (c) 2026. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc. FAU - Gheorghita, Irina AU - Gheorghita I AD - Universitat Rovira i Virgili, Pediatric, Nutrition and Development Research Unit (PediNuR), Reus, Spain. AD - Institut de Recerca Biomedica Catalunya Sud, Reus, Spain. FAU - Gispert-Llaurado, Mariona AU - Gispert-Llaurado M AD - Universitat Rovira i Virgili, Pediatric, Nutrition and Development Research Unit (PediNuR), Reus, Spain. mariona.gispert@irbcatsud.cat. AD - Institut de Recerca Biomedica Catalunya Sud, Reus, Spain. mariona.gispert@irbcatsud.cat. FAU - Escribano, Joaquin AU - Escribano J AD - Universitat Rovira i Virgili, Pediatric, Nutrition and Development Research Unit (PediNuR), Reus, Spain. AD - Institut de Recerca Biomedica Catalunya Sud, Reus, Spain. AD - Hospital Universitari Sant Joan de Reus, Reus, Spain. FAU - Jurado-Castro, Jose Manuel AU - Jurado-Castro JM AD - University of Cordoba, Metabolism and Investigation Unit, Reina Sofia University Hospital. Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), Cordoba, Spain. AD - Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, 28029, Spain. FAU - Babio, Nancy AU - Babio N AD - Institut de Recerca Biomedica Catalunya Sud, Reus, Spain. AD - Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, 28029, Spain. AD - Universitat Rovira i Virgili, Unitat de Nutricio Humana, Grup ANUT-DSM, Departament de Bioquimica i Biotecnologia, Reus, Spain. FAU - Leis, Rosaura AU - Leis R AD - Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, 28029, Spain. AD - Unit of Pediatric Gastroenterology, Hepatology and Nutrition, Pediatric Service, University Clinical Hospital of Santiago, Santiago de Compostela, 15706, Spain. AD - Pediatric Nutrition Research Group, Health Research Institute of Santiago de Compostela (IDIS), Unit of Investigation in Nutrition, Growth and Human Development of Galicia-USC, Santiago de Compostela, 15706, Spain. FAU - Moreno, Luis A AU - Moreno LA AD - Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, 28029, Spain. AD - Growth, Exercise, Nutrition and Development (GENUD-B34_23R) Research Group, University of Zaragoza, Zaragoza, Spain. AD - Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. AD - Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza, Zaragoza, Spain. FAU - Navas-Carretero, Santiago AU - Navas-Carretero S AD - Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, 28029, Spain. AD - University of Navarra, Department of Nutrition, Food Sciences, and Physiology, Center for Nutrition Research, Pamplona, Spain. AD - IdisNA, Navarra Institute for Health Research, Pamplona, Spain. FAU - Corella, Dolores AU - Corella D AD - Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, 28029, Spain. AD - Departament of Preventive Medicine and Public Health, University of Valencia, Valencia, Spain. FAU - Moreira, Ana AU - Moreira A AD - Fundacio Hospital Sant Joan de Deu de Martorell, Martorell, Spain. FAU - Castro-Collado, Cristina AU - Castro-Collado C AD - University of Cordoba, Metabolism and Investigation Unit, Reina Sofia University Hospital. Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), Cordoba, Spain. FAU - Vazquez-Cobela, Rocio AU - Vazquez-Cobela R AD - Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, 28029, Spain. AD - Unit of Pediatric Gastroenterology, Hepatology and Nutrition, Pediatric Service, University Clinical Hospital of Santiago, Santiago de Compostela, 15706, Spain. AD - Pediatric Nutrition Research Group, Health Research Institute of Santiago de Compostela (IDIS), Unit of Investigation in Nutrition, Growth and Human Development of Galicia-USC, Santiago de Compostela, 15706, Spain. FAU - Alcazar, Mireia AU - Alcazar M AD - Universitat Rovira i Virgili, Pediatric, Nutrition and Development Research Unit (PediNuR), Reus, Spain. AD - Institut de Recerca Biomedica Catalunya Sud, Reus, Spain. FAU - Miguel-Berges, Maria L AU - Miguel-Berges ML AD - Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, 28029, Spain. AD - Growth, Exercise, Nutrition and Development (GENUD-B34_23R) Research Group, University of Zaragoza, Zaragoza, Spain. AD - Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. AD - Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza, Zaragoza, Spain. FAU - Martinez, J Alfredo AU - Martinez JA AD - Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, 28029, Spain. AD - University of Navarra, Department of Nutrition, Food Sciences, and Physiology, Center for Nutrition Research, Pamplona, Spain. AD - Precision Nutrition and Cardiometabolic Health Program. IMDEA Food, CEI UAM+CSIC, Madrid, Spain. AD - Endocrinology and Nutrition Institute, Universidad de Valladolid, Valladolid, Spain. FAU - Pastor-Villaescusa, Belen AU - Pastor-Villaescusa B AD - University of Cordoba, Metabolism and Investigation Unit, Reina Sofia University Hospital. Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), Cordoba, Spain. AD - Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS), RD21/0012/0008, Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS-SAMID, RD24/0013/0007), Instituto de Salud Carlos III, Madrid, Spain. FAU - Picans-Leis, Rosaura AU - Picans-Leis R AD - Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS), RD21/0012/0008, Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS-SAMID, RD24/0013/0007), Instituto de Salud Carlos III, Madrid, Spain. AD - Neonatology Service, University Clinical Hospital of Santiago de Compostela-University of Santiago de Compostela. Health Research Institute of Santiago de Compostela (IDIS), Santiago de Compostela, Spain. FAU - Mimbrero, Gisela AU - Mimbrero G AD - EAP-CAP Sant Pere. Reus 2. Institut Catala de la Salut, Generalitat de Catalunya, Spain. FAU - De Miguel-Etayo, Pilar AU - De Miguel-Etayo P AD - Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, 28029, Spain. AD - Growth, Exercise, Nutrition and Development (GENUD-B34_23R) Research Group, University of Zaragoza, Zaragoza, Spain. AD - Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. AD - Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza, Zaragoza, Spain. FAU - Flores-Rojas, Katherine AU - Flores-Rojas K AD - University of Cordoba, Metabolism and Investigation Unit, Reina Sofia University Hospital. Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), Cordoba, Spain. FAU - Gil-Campos, Mercedes AU - Gil-Campos M AD - University of Cordoba, Metabolism and Investigation Unit, Reina Sofia University Hospital. Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), Cordoba, Spain. AD - Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, 28029, Spain. FAU - Salas-Salvado, Jordi AU - Salas-Salvado J AD - Institut de Recerca Biomedica Catalunya Sud, Reus, Spain. AD - Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III (ISCIII), Madrid, 28029, Spain. AD - Universitat Rovira i Virgili, Unitat de Nutricio Humana, Grup ANUT-DSM, Departament de Bioquimica i Biotecnologia, Reus, Spain. FAU - Luque, Veronica AU - Luque V AD - Universitat Rovira i Virgili, Pediatric, Nutrition and Development Research Unit (PediNuR), Reus, Spain. veronica.luque@urv.cat. AD - Institut de Recerca Biomedica Catalunya Sud, Reus, Spain. veronica.luque@urv.cat. AD - Serra Hunter Fellow, Universitat Rovira i Virgili, Tarragona, Spain. veronica.luque@urv.cat. CN - CORALS study investigators LA - eng PT - Journal Article DEP - 20260414 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Consent statement: Parents or legal guardians of the participants had to sign an informed consent form to be included in the study. FIR - Schroder, Helmut IR - Schroder H FIR - Fito, Montse IR - Fito M FIR - Perez-Vega, Karla A IR - Perez-Vega KA FIR - Solis Baltodano, Mayela IR - Solis Baltodano M FIR - Munoz-Aguayo, Daniel IR - Munoz-Aguayo D FIR - Blanchart, Gemma IR - Blanchart G FIR - Gaixas, Sonia IR - Gaixas S FIR - Zomeno, Maria Dolores IR - Zomeno MD FIR - Lorenzo, Isaury IR - Lorenzo I FIR - Gil-Campos, Mercedes IR - Gil-Campos M FIR - Jurado-Castro, Jose Manuel IR - Jurado-Castro JM FIR - Pastor-Villaescusa, Belen IR - Pastor-Villaescusa B FIR - Llorente-Cantarero, Francisco Jesus IR - Llorente-Cantarero FJ FIR - De La Torre-Aguilar, Maria Jose IR - De La Torre-Aguilar MJ FIR - Velasco Aguayo, Inmaculada IR - Velasco Aguayo I FIR - Navas-Carretero, Santiago IR - Navas-Carretero S FIR - Martinez, J Alfredo IR - Martinez JA FIR - Moreno-Aliaga, Maria Jesus IR - Moreno-Aliaga MJ FIR - de Cuevillas Garcia, Begona IR - de Cuevillas Garcia B FIR - Vazquez-Bolea, Natalia IR - Vazquez-Bolea N FIR - Goni, Maria IR - Goni M FIR - Hernandez, Maria IR - Hernandez M FIR - Perez Diez, Salome IR - Perez Diez S FIR - Cristobo, Carmen IR - Cristobo C FIR - Babio, Nancy IR - Babio N FIR - Salas-Salvado, Jordi IR - Salas-Salvado J FIR - Escribano, Joaquin IR - Escribano J FIR - Luque, Veronica IR - Luque V FIR - Ferre, Natalia IR - Ferre N FIR - Gheorghita, Irina IR - Gheorghita I FIR - Feliu, Albert IR - Feliu A FIR - Closa, Ricardo IR - Closa R FIR - Alcazar, Mireia IR - Alcazar M FIR - Martin, Francisco IR - Martin F FIR - Rey, Cristina IR - Rey C FIR - Mimbrero, Gisela IR - Mimbrero G FIR - Pedraza, Ana IR - Pedraza A FIR - Salvado, Olga IR - Salvado O FIR - Ruiz Velasco, Marta IR - Ruiz Velasco M FIR - Bilbao Sustacha, Jose Angel IR - Bilbao Sustacha JA FIR - Herranz Pinilla, Yolanda IR - Herranz Pinilla Y FIR - Rios, Lidia IR - Rios L FIR - Pascual Compte, Maria IR - Pascual Compte M FIR - Garciduenas-Fimbres, Tany E IR - Garciduenas-Fimbres TE FIR - Gomez-Martinez, Carlos IR - Gomez-Martinez C FIR - de Las Heras-Delgado, Sara IR - de Las Heras-Delgado S FIR - Simon, Olga IR - Simon O FIR - de la Torre, Sonia IR - de la Torre S FIR - Tudela, Carol IR - Tudela C FIR - Valero Sales, Julia IR - Valero Sales J FIR - Morono Garcia, Sara IR - Morono Garcia S FIR - Leis, Rosaura IR - Leis R FIR - Romero Agrelo, Anabel IR - Romero Agrelo A FIR - Picans-Leis, Rosaura IR - Picans-Leis R FIR - Garcia-Garcia, Eva IR - Garcia-Garcia E FIR - Mosteiro-Losada, Sofia IR - Mosteiro-Losada S FIR - Portoles, Olga IR - Portoles O FIR - Codoner Franch, Pilar IR - Codoner Franch P FIR - Corella, Dolores IR - Corella D FIR - Martin Carbonell, Vanessa IR - Martin Carbonell V FIR - Sorli, Jose V IR - Sorli JV FIR - Moreno, Luis A IR - Moreno LA FIR - De Miguel-Etayo, Pilar IR - De Miguel-Etayo P FIR - Miguel-Berges, Maria Luisa IR - Miguel-Berges ML FIR - Santaliestra-Pasias, Alba M feminine IR - Santaliestra-Pasias AM FIR - Argente-Arizon, Pilar IR - Argente-Arizon P FIR - Gimenez-Legarre, Natalia IR - Gimenez-Legarre N FIR - Flores-Barrantes, Paloma IR - Flores-Barrantes P FIR - Perez-Gimeno, Gloria IR - Perez-Gimeno G FIR - Seral-Cortes, Miguel IR - Seral-Cortes M FIR - Jimeno-Martinez, Andrea IR - Jimeno-Martinez A FIR - Maneschy, Ivie IR - Maneschy I FIR - Benedicto, Isabel IR - Benedicto I EDAT- 2026/04/15 00:31 MHDA- 2026/04/15 00:31 CRDT- 2026/04/14 23:23 PHST- 2025/04/02 00:00 [received] PHST- 2026/01/10 00:00 [accepted] PHST- 2025/12/12 00:00 [revised] PHST- 2026/04/15 00:31 [medline] PHST- 2026/04/15 00:31 [pubmed] PHST- 2026/04/14 23:23 [entrez] AID - 10.1038/s41390-026-04889-6 [pii] AID - 10.1038/s41390-026-04889-6 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Apr 14. doi: 10.1038/s41390-026-04889-6. PMID- 41981091 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Apr 14 TI - Spinal pain and associated factors among young motorcyclists a cross-sectional study with mediating analysis. LID - 10.1038/s41598-026-48458-7 [doi] LID - 17285 AB - Spinal pain is a common musculoskeletal complaint among young adults and is sometimes influenced by lifestyle and behavioral factors. Motorcycles are the most common and convenient means of transportation in India, especially among the younger population. This study aimed to estimate the prevalence of spinal pain among young motorcycle riders and examine the predictors associated with spinal pain, while exploring the statistical mediating role of body mass index (BMI). The study was conducted at a large multidisciplinary higher education institution in India with approximately 60,000 students across 300 programs. As motorcycles are one of the common modes of transport, 422 eligible motorcycle riders were recruited for this study. Data were collected using systematic random sampling, a structured expert-validated questionnaire, and physical measurements. Bivariate and multivariate binary logistic regression model analysis was used to identify factors associated with spinal pain. A bootstrapped mediation analysis was performed to determine the extent to which the mediator variable (i.e., BMI) explained the association between the riding frequency and spinal pain. The overall cumulative prevalence of self-reported spinal pain experienced in the past year was 37.7% (95% CI: 32.7, 42.5). Factors like obesity (AOR 6.24, 95% CI: 1.9, 20.49), being overweight (AOR 2.78, 95% CI: 1.21, 6.37), not engaging in regular physical activity (AOR 2.24, 95% CI: 1.44, 3.48), experiencing fatigue while driving (AOR 2.66, 95% CI: 1.62, 4.42), and being female (AOR 1.87, 95% CI: 1.47, 2.97) were significantly associated with the likelihood of self-reported spinal pain among young motorcyclists in a multivariate logistic model with the level of significance set at 0.05. Furthermore, BMI appeared to partially explain the relationship between bike riding and spinal pain. Spinal pain was common among young motorcycle riders, and it is associated with higher BMI, riding fatigue, and physical inactivity. BMI partially explained the association between riding frequency and spinal pain. The findings highlight the potential importance of healthy body weight, regular physical activity, and addressing riding-related fatigue as part of spinal health strategies among young motorcycle riders. CI - (c) 2026. The Author(s). FAU - Rajan, Jona Edward AU - Rajan JE AD - SRM College of Physiotherapy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology (SRM IST), Kattankulathur, 603203, Tamil Nadu, India. FAU - Janakiraman, Balamurugan AU - Janakiraman B AD - SRM College of Physiotherapy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology (SRM IST), Kattankulathur, 603203, Tamil Nadu, India. bala77physio@gmail.com. FAU - T S, Veeragoudhaman AU - T S V AD - SRM College of Physiotherapy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology (SRM IST), Kattankulathur, 603203, Tamil Nadu, India. FAU - Ravichandran, Hariharasudhan AU - Ravichandran H AD - Faculty of Physiotherapy, Meenakshi Academy of Higher Education and Research (MAHER), Chennai, Tamil Nadu, India. AD - Department of Physiotherapy, Alvas College of Physiotherapy and Research Centre, Moodbidri, Dakshina Kannada, 574227, Karnataka, India. FAU - Sidiq, Mohammad AU - Sidiq M AD - Physiotherapy Department, Tishk International University, Erbil, Iraq. FAU - Sharma, Jyoti AU - Sharma J AD - Department of Physiotherapy, School of Allied Health Sciences, Galgotias University, Greater Noida, 203201, Uttar Pradesh, India. FAU - Nageswari, C AU - Nageswari C AD - Department of Physiotherapy, School of Allied Health Sciences, Galgotias University, Greater Noida, 203201, Uttar Pradesh, India. FAU - Kashoo, Faizan AU - Kashoo F AD - Department of Physical Therapy and Health Rehabilitation, College of Applied Medical Sciences, Majmaah University, Al Majmaah, Saudi Arabia. FAU - Arasu, Vinitha AU - Arasu V AD - SRM College of Physiotherapy, Faculty of Medicine and Health Sciences, SRM Institute of Science and Technology (SRM IST), Kattankulathur, 603203, Tamil Nadu, India. FAU - Agarwal, Vaibhav AU - Agarwal V AD - Department of Physiotherapy, Swami Rama Himalayan University, Jolly Grant, 248016, Dehradun, Uttrakhand, India. FAU - Vyas, Neha AU - Vyas N AD - Department of Physiotherapy, University of Engineering and Management, Jaipur, 303807, India. FAU - Alshehri, Mohammed M AU - Alshehri MM AD - Department of Physical Therapy, College of Applied Medical Sciences, Jazan University, Jazan, Saudi Arabia. FAU - Aldhahi, Monira I AU - Aldhahi MI AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh, 11671, Saudi Arabia. mialdhahi@pnu.edu.sa. LA - eng GR - PNURSP2026R286/Princess Nourah bint Abdulrahman University/ PT - Journal Article DEP - 20260414 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Motorcycles MH - Body Mass Index MH - Female MH - Cross-Sectional Studies MH - Male MH - Young Adult MH - India/epidemiology MH - Prevalence MH - Adolescent MH - *Back Pain/epidemiology MH - Risk Factors PMC - PMC13234135 OTO - NOTNLM OT - BMI OT - Mediation effect OT - Motorcyclists OT - Spinal pain OT - Young adult COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/04/15 00:33 MHDA- 2026/06/11 06:38 PMCR- 2026/04/14 CRDT- 2026/04/14 23:23 PHST- 2025/07/29 00:00 [received] PHST- 2026/04/08 00:00 [accepted] PHST- 2026/06/11 06:38 [medline] PHST- 2026/04/15 00:33 [pubmed] PHST- 2026/04/14 23:23 [entrez] PHST- 2026/04/14 00:00 [pmc-release] AID - 10.1038/s41598-026-48458-7 [pii] AID - 48458 [pii] AID - 10.1038/s41598-026-48458-7 [doi] PST - epublish SO - Sci Rep. 2026 Apr 14;16(1):17285. doi: 10.1038/s41598-026-48458-7. PMID- 41980876 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1365-2214 (Electronic) IS - 0305-1862 (Print) IS - 0305-1862 (Linking) VI - 52 IP - 3 DP - 2026 May TI - The Early Movers Clinician's Guide: Co-Designing a Resource for the 24-Hour Movement Guidelines in Paediatric Occupational Therapy. PG - e70275 LID - 10.1111/cch.70275 [doi] LID - e70275 AB - BACKGROUND: Balancing physical activity, sedentary time and sleep is important for the well-being of preschoolers (3-4 years) with disabilities. Occupational Therapists (OTs) are important disseminators of the Canadian 24-Hour Movement Guidelines for the Early Years but require a resource for clinical implementation. This study aimed to co-design and assess the content validity of such a resource. METHODS: Using the Framework for Co-design of Clinical Tools, five workshops were conducted with an advisory council of OTs (n = 9) and caregivers of children with disabilities (n = 5) to co-design the resource. Researchers (n = 6) consulted on the scientific integrity of the resource. Thematic analysis was used to summarize workshop data for the co-design process and examine content validity. RESULTS: The Early Movers Clinician's Guide, an open access resource to support OTs in using the guidelines was created. Themes reflected within the co-design process included the importance of a person-centred approach, meaningful measurement and context-driven information sharing. Participants reported positive perceptions of the resource's content validity, supporting its potential for clinical application. CONCLUSIONS: The Early Movers Clinician's Guide was co-designed to support OTs in translating the guidelines into practice with preschoolers with disabilities. Future research will evaluate broader implementation. CI - (c) 2026 The Author(s). Child: Care, Health and Development published by John Wiley & Sons Ltd. FAU - Taylor, Leah G AU - Taylor LG AUID- ORCID: 0000-0003-3731-492X AD - Health and Rehabilitation Sciences, Western University, London, Canada. AD - School of Occupational Therapy, Western University, London, Canada. FAU - Phillips, Sophie M AU - Phillips SM AUID- ORCID: 0000-0003-4140-8013 AD - School of Occupational Therapy, Western University, London, Canada. FAU - Tzvetkov, Denis AU - Tzvetkov D AD - School of Kinesiology, Western University, London, Canada. FAU - Alvarez, Liliana AU - Alvarez L AUID- ORCID: 0000-0001-9934-3414 AD - School of Occupational Therapy, Western University, London, Canada. FAU - Tucker, Patricia AU - Tucker P AUID- ORCID: 0000-0002-8392-9418 AD - School of Occupational Therapy, Western University, London, Canada. AD - Children's Health Research Institute, Lawson Health Research Institute, London, Canada. LA - eng GR - CAPMC/CIHR/Canada GR - Western University/ GR - North American Society for Paediatric Exercise Medicine/ GR - Public Health Agency of Canada/ GR - Canadian Disability Participation Project/ PT - Journal Article PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM MH - Humans MH - Child, Preschool MH - *Occupational Therapy/methods/standards MH - *Children with Disabilities/rehabilitation MH - Practice Guidelines as Topic MH - Canada MH - Female MH - *Exercise MH - Male MH - Occupational Therapists PMC - PMC13078964 OTO - NOTNLM OT - clinical tool OT - codesign OT - disability* OT - knowledge translation OT - movement behaviourpreschool* COIS- The authors declare no conflicts of interest. EDAT- 2026/04/15 00:35 MHDA- 2026/04/15 00:36 PMCR- 2026/04/15 CRDT- 2026/04/14 22:02 PHST- 2026/03/24 00:00 [revised] PHST- 2025/12/10 00:00 [received] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/04/15 00:36 [medline] PHST- 2026/04/15 00:35 [pubmed] PHST- 2026/04/14 22:02 [entrez] PHST- 2026/04/15 00:00 [pmc-release] AID - CCH70275 [pii] AID - 10.1111/cch.70275 [doi] PST - ppublish SO - Child Care Health Dev. 2026 May;52(3):e70275. doi: 10.1111/cch.70275. PMID- 41980588 OWN - NLM STAT- MEDLINE DCOM- 20260826 LR - 20260826 IS - 1438-9010 (Electronic) IS - 1438-9010 (Linking) VI - 198 IP - 9 DP - 2026 Sep TI - Predicting Exceedance of National Diagnostic Reference Levels for Two-view Chest Radiography in Germany based on Patients' Body Mass Index. PG - 1206-1212 LID - 10.1055/a-2810-5285 [doi] AB - PURPOSE: Two-view chest X-ray (CXR) is a widely utilized diagnostic tool due to its accessibility, cost-effectiveness, and ability to evaluate thoracic pathologies. The current diagnostic reference levels (DRLs) in Germany for posterior-anterior (PA) and lateral CXR are 12.0 and 40.0 cGy x cm(2), respectively. This study assessed the dose contributions of PA and lateral CXR for different body mass index (BMI) groups, aiming to determine the best possible BMI thresholds to predict exceedance of the national DRLs. MATERIALS AND METHODS: In this retrospective study, 3,982 patients underwent a total of 4,958 two-view chest radiograms using a twin robotic X-ray system. Dose-area products (DAP) of each BMI group were compared between projections using Wilcoxon signed rank tests. Receiver operating characteristic statistics were employed to identify BMI values likely to result in doses above the DRLs. RESULTS: For each BMI group, lateral CXR resulted in higher DAP than PA radiograms (all p<0.001). The smallest median DAP difference was found for underweight patients (BMI <18.5 kg/m(2); 12.2 versus 4.8 cGy x cm(2); 154.2% higher DAP in lateral CXR), whereas the largest difference was observed among severely obese individuals (>40.0 kg/m(2); 142.1 versus 21.7 cGy x cm(2); 554.8%). The correlation of BMI and DAP was strong for both lateral and PA CXR (r = 0.614 and 0.641, both p<0.001). The best possible BMI thresholds to predict DRL exceedance were determined to be 26.5 kg/m(2) for lateral CXR (72.6% sensitivity / 76.1% specificity) and 27.8 kg/m(2) for PA radiograms (78.1% / 74.4%). CONCLUSION: BMI information facilitates prediction of DRL exceedance. The findings presented may serve as a basis for future discussions on whether BMI-dependent reference levels could help to optimize dose management in chest imaging. KEY POINTS: . Lateral views contribute the majority of radiation dose in two-view CXR.. . Patient BMI correlates strongly with dose exposure.. . Recording patient height and weight information is helpful for radiation dose management.. CITATION FORMAT: . Huflage H, Razinskas G, Weick S et al. Predicting Exceedance of the National Diagnostic Reference Levels for Two-view Chest Radiography in Germany based on Patients' Body Mass Index. Rofo 2026; DOI 10.1055/a-2810-5285. CI - Thieme. All rights reserved. FAU - Huflage, Henner AU - Huflage H AD - University Hospital Wurzburg, Department of Diagnostic and Interventional Radiology, BY, Germany, Wurzburg. FAU - Razinskas, Gary AU - Razinskas G AD - University Hospital Wurzburg, Department of Radiation Oncology, BY, Germany, Wurzburg. FAU - Weick, Stefan AU - Weick S AD - University Hospital Wurzburg, Department of Radiation Oncology, BY, Germany, Wurzburg. FAU - Kunz, Andreas Steven AU - Kunz AS AD - University Hospital Wurzburg, Department of Diagnostic and Interventional Radiology, BY, Germany, Wurzburg. FAU - Hendel, Robin AU - Hendel R AD - University Hospital Wurzburg, Department of Diagnostic and Interventional Radiology, BY, Germany, Wurzburg. FAU - Wech, Tobias AU - Wech T AD - University Hospital Wurzburg, Department of Diagnostic and Interventional Radiology, BY, Germany, Wurzburg. FAU - Muller, Lukas AU - Muller L AD - University Medical Center of the Johannes Gutenberg University Mainz, Department for Diagnostic and Interventional Radiology, Germany, Mainz. FAU - Bley, Thorsten AU - Bley T AD - University Hospital Wurzburg, Department of Diagnostic and Interventional Radiology, BY, Germany, Wurzburg. FAU - Grunz, Jan-Peter AU - Grunz JP AUID- ORCID: 0000-0002-4524-1620 AD - University Hospital Wurzburg, Department of Diagnostic and Interventional Radiology, BY, Germany, Wurzburg. LA - eng PT - Journal Article TT - Vorhersage von Uberschreitungen der diagnostischen Referenzwerte fur die Thorax-Radiografie in Deutschland auf der Grundlage des Body-Mass-Index. DEP - 20260414 PL - Germany TA - Rofo JT - RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin JID - 7507497 SB - IM MH - Humans MH - *Body Mass Index MH - *Radiography, Thoracic/standards/statistics & numerical data MH - Germany/epidemiology MH - Female MH - Male MH - Middle Aged MH - Retrospective Studies MH - Radiation Dosage MH - Adult MH - Diagnostic Reference Levels MH - Aged MH - Sensitivity and Specificity MH - Aged, 80 and over MH - Adolescent MH - Young Adult MH - Reference Values COIS- Thorsten Bley and Jan-Peter Grunz have received speaker honoraria from Siemens Healthineers within the last three years. The Department of Diagnostic and Interventional Radiology at University Hospital Wurzburg receives ongoing research funding from Siemens Healthineers. EDAT- 2026/04/15 00:34 MHDA- 2026/08/26 23:35 CRDT- 2026/04/14 18:52 PHST- 2026/08/26 23:35 [medline] PHST- 2026/04/15 00:34 [pubmed] PHST- 2026/04/14 18:52 [entrez] AID - 10.1055/a-2810-5285 [doi] PST - ppublish SO - Rofo. 2026 Sep;198(9):1206-1212. doi: 10.1055/a-2810-5285. Epub 2026 Apr 14. PMID- 41980491 OWN - NLM STAT- MEDLINE DCOM- 20260820 LR - 20260821 IS - 1879-680X (Electronic) IS - 1761-7727 (Linking) VI - 24 IP - 3 DP - 2026 Sep TI - A comparison of spheno-occipital synchondrosis fusion, hand-wrist maturation, and cervical vertebral maturation for assessing skeletal maturation in Chinese adolescents: A cross-sectional study. PG - 101166 LID - S1761-7227(26)00029-X [pii] LID - 10.1016/j.ortho.2026.101166 [doi] AB - OBJECTIVE: This study aimed to assess the validity and reliability of spheno-occipital synchondrosis fusion stages as a skeletal maturity indicator by comparing it with the established Bjork hand-wrist maturation (HWM) index and Baccetti cervical vertebral maturation (CVM) stages. METHODS: CBCT scans, hand-wrist radiographs, and lateral cephalograms of 177 patients (78 males, 99 females; aged 7.3-16.9years) were evaluated to determine the stages of SOS fusion, HWM, and CVM, respectively. Spearman correlation coefficients and weighted kappa coefficients were used to assess the pairwise correlations and the degree of agreement. The diagnostic performance of each SOS stage for identifying its corresponding HWM or CVM stage was evaluated using ROC curve analysis. RESULTS: A strong positive correlation and substantial agreement were observed between all pairs of skeletal maturity indicators in both sexes. Regarding agreement, SOS and HWM showed the highest concordance (males: kappa=0.781; females: kappa=0.788), followed by CVM and HWM (males: kappa=0.752; females: kappa=0.717), and then SOS and CVM (males: kappa=0.722; females: kappa=0.692). Among females, SOS and HWM showed the strongest correlation (r=0.891), followed by CVM and HWM (r=0.861), and SOS and CVM (r=0.830). Among males, CVM and HWM had the highest correlation (r=0.883), followed by SOS and HWM (r=0.877), and SOS and CVM (r=0.838). CONCLUSION: SOS fusion demonstrated strong correlations and overall substantial agreement with both HWM and CVM, supporting its use as a valid and reliable indicator of skeletal maturity. CI - Copyright (c) 2026 CEO. Published by Elsevier Masson SAS. All rights reserved. FAU - Ouyang, Tingting AU - Ouyang T AD - Department of Orthodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China. FAU - Liu, Haibo AU - Liu H AD - Department of Stomatology, Xiangnan Hospital Affiliated to Hunan Normal University/922th Hospital of Joint Logistics Support Force, PLA. FAU - Liu, Chang AU - Liu C AD - Department of Orthodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China. FAU - Shi, Qilu AU - Shi Q AD - Department of Orthodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China. FAU - Liu, Yajuan AU - Liu Y AD - Department of Orthodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China. FAU - Wu, Xiaoxue AU - Wu X AD - Department of Orthodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, China. Electronic address: xiaoxueW@gzhmu.edu.cn. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260413 PL - France TA - Int Orthod JT - International orthodontics JID - 101184882 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Age Determination by Skeleton/methods MH - Bone Development MH - Cephalometry MH - *Cervical Vertebrae/growth & development/diagnostic imaging MH - China MH - Cone-Beam Computed Tomography MH - Cross-Sectional Studies MH - *Hand/growth & development/diagnostic imaging MH - *Occipital Bone/growth & development/diagnostic imaging MH - Reproducibility of Results MH - *Sphenoid Bone/growth & development/diagnostic imaging MH - *Wrist/growth & development/diagnostic imaging OTO - NOTNLM OT - Cervical vertebrae maturation OT - Growth prediction OT - Hand-wrist maturation OT - Spheno-occipital synchondrosis EDAT- 2026/04/15 00:33 MHDA- 2026/08/20 23:35 CRDT- 2026/04/14 18:28 PHST- 2025/12/10 00:00 [received] PHST- 2026/03/19 00:00 [revised] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/08/20 23:35 [medline] PHST- 2026/04/15 00:33 [pubmed] PHST- 2026/04/14 18:28 [entrez] AID - S1761-7227(26)00029-X [pii] AID - 10.1016/j.ortho.2026.101166 [doi] PST - ppublish SO - Int Orthod. 2026 Sep;24(3):101166. doi: 10.1016/j.ortho.2026.101166. Epub 2026 Apr 13. PMID- 41979151 OWN - NLM STAT- MEDLINE DCOM- 20260814 LR - 20260814 IS - 1536-7312 (Electronic) IS - 0196-206X (Linking) VI - 47 IP - 4 DP - 2026 Jul-Aug 01 TI - Clinical Research Facilitators, Barriers, and Preferences of Parents of Children With Overweight and Obesity. PG - e453-e460 LID - 10.1097/DBP.0000000000001482 [doi] AB - OBJECTIVE: Recruiting, enrolling, and retaining families in pediatric obesity clinical trials is challenging. This study examined perceptions of facilitators and barriers related to clinical research, and preferences of specific research formats, in parents of a child with overweight or obesity. Associations between parental research perceptions and sociodemographic and health factors were also explored. METHOD: A descriptive, cross-sectional online survey of 103 parents of children 2 to 17 years with overweight or obesity was conducted between May 2021 and March 2022 in the southeastern US. Barriers and facilitators of research participation, child weight status, child COVID-19 health care and parental COVID-19 stress, demographic characteristics (e.g., child age, child gender, child race/ethnicity, family income, geographic location), and preferences for specific research formats (e.g., telehealth, in person, group sessions, individual sessions, COVID-19 testing, single-dose COVID-19 vaccine, and multiple-dose COVID-19 vaccine) were assessed. Linear regression analyses were conducted. RESULTS: Parents endorsed more reasons and benefits for participation than mistrust, social pressure, and reasons against participation. Lower child body mass index was associated with higher perceptions of research participation benefits. Pandemic parental stress was associated with increased social pressure and benefits. Parents of non-Hispanic White and male youth endorsed more mistrust of clinical research. CONCLUSION: Findings can inform future pediatric overweight and obesity clinical research and trial designs to enable equitable recruitment, reduce participation burden, and increase feasibility and sustainability of interventions. CI - Copyright (c) 2026 Wolters Kluwer Health, LLC. All rights reserved. FAU - Lim, Crystal S AU - Lim CS AUID- ORCID: 0000-0002-7445-7463 AD - Department of Health Psychology, University of Missouri, Columbia, MO. FAU - Patel, Devanshi J AU - Patel DJ AD - Cincinnati Children's Hospital Medical Center, Cincinnati, OH. FAU - Casady, Hannah AU - Casady H AD - Department of Health Psychology, University of Missouri, Columbia, MO. FAU - Sandridge, Shanda AU - Sandridge S AD - Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS. FAU - Dodd, Cameronne A AU - Dodd CA AD - Department of Pharmacology and Toxicology, University of Mississippi Medical Center, Jackson, MS; and. FAU - Malloch, Lacy AU - Malloch L AD - Department of Pediatrics, University of Mississippi Medical Center, Jackson, MS. FAU - Annett, Robert D AU - Annett RD AD - Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM. LA - eng GR - 5U54GM115428/NIGMS/NIH/ PT - Journal Article DEP - 20260414 PL - United States TA - J Dev Behav Pediatr JT - Journal of developmental and behavioral pediatrics : JDBP JID - 8006933 SB - IM MH - Humans MH - Male MH - Female MH - Child MH - *Parents/psychology MH - Adolescent MH - Cross-Sectional Studies MH - *Pediatric Obesity/therapy MH - Child, Preschool MH - Adult MH - *COVID-19/prevention & control MH - *Biomedical Research MH - Overweight OTO - NOTNLM OT - child health research OT - clinical trial recruitment OT - parental attitudes OT - pediatric overweight COIS- Disclosure: The authors declare no conflict of interest. EDAT- 2026/04/14 12:35 MHDA- 2026/08/14 17:39 CRDT- 2026/04/14 07:13 PHST- 2025/08/18 00:00 [received] PHST- 2026/02/11 00:00 [accepted] PHST- 2026/08/14 17:39 [medline] PHST- 2026/04/14 12:35 [pubmed] PHST- 2026/04/14 07:13 [entrez] AID - 00004703-990000000-00361 [pii] AID - 10.1097/DBP.0000000000001482 [doi] PST - ppublish SO - J Dev Behav Pediatr. 2026 Jul-Aug 01;47(4):e453-e460. doi: 10.1097/DBP.0000000000001482. Epub 2026 Apr 14. PMID- 41979075 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260813 IS - 1365-2516 (Electronic) IS - 1351-8216 (Print) IS - 1351-8216 (Linking) VI - 32 IP - 4 DP - 2026 Jul-Aug TI - Haemophilia Joint Health Score Ranges Across the Lifespan: Variation by Haemophilia Type and Severity. PG - 1016-1024 LID - 10.1111/hae.70283 [doi] AB - INTRODUCTION: The Haemophilia Joint Health Score (HJHS) is a validated physical exam measure of haemophilic arthropathy, used clinically to determine treatment adequacy. Higher scores are worse; however, there is no consensus on a clinically significant score. AIM: To establish HJHS reference ranges based on age and haemophilia type and severity, relative to prophylaxis, inhibitor status, annualised bleeding rate and body mass index. METHODS: This is a cross-sectional analysis of HJHS exams performed between 2012 and 2021 by the University of Colorado Hemophilia and Thrombosis Center in persons with Factor VIII or IX <50%. For each haemophilia type, severity and age group, reference ranges were defined using interquartile ranges, and the percentage of joints with scores overlapping healthy controls were calculated. Univariate and multivariable linear regression determined the influence of modifiers on total HJHS. The association between total HJHS and pain on exam was also evaluated. RESULTS: Initial analysis of all participants showed female and male HJHS values to be statistically different for reasons requiring further investigation; subsequent analyses were limited to males. Multivariable linear regression derived from data on 385 males showed that for each 1-year age increase, total HJHS was 0.5 points higher. Total HJHS were 3.9 points higher in Haemophilia A than Haemophilia B. Ranked haemophilia severity (severe > moderate > mild) incurred 2.4 point increases in total HJHS. Pain was present in 76% of joints with individual joint scores >10. CONCLUSION: This study quantifies current differences in total HJHS relative to haemophilia type, severity, age and treatment in males. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Warren, Beth Boulden AU - Warren BB AD - University of Colorado Hemophilia and, Thrombosis Center, Aurora, Colorado, USA. FAU - Thornhill, Dianne AU - Thornhill D AD - University of Colorado Hemophilia and, Thrombosis Center, Aurora, Colorado, USA. FAU - Singer-Fox, Laura AU - Singer-Fox L AD - University of Colorado Hemophilia and, Thrombosis Center, Aurora, Colorado, USA. FAU - Smith, Julie AU - Smith J AD - University of Colorado Hemophilia and, Thrombosis Center, Aurora, Colorado, USA. FAU - Funk, Sharon AU - Funk S AD - University of Colorado Hemophilia and, Thrombosis Center, Aurora, Colorado, USA. FAU - Manco-Johnson, Marilyn AU - Manco-Johnson M AD - University of Colorado Hemophilia and, Thrombosis Center, Aurora, Colorado, USA. LA - eng GR - K23 HL151886/HL/NHLBI NIH HHS/United States GR - 2H30MC24049/Maternal Child Health Bureau and the Health Resources and Services Administration (HRSA) of the US Department of Health and Human Services (HHS)/ GR - Mountain States Hemophilia Network/ PT - Journal Article DEP - 20260414 PL - England TA - Haemophilia JT - Haemophilia : the official journal of the World Federation of Hemophilia JID - 9442916 SB - IM MH - Humans MH - Male MH - *Hemophilia A/pathology/complications MH - Cross-Sectional Studies MH - Female MH - Severity of Illness Index MH - Adult MH - Adolescent MH - Child MH - Young Adult MH - Middle Aged MH - *Joints/pathology MH - Child, Preschool MH - Aged MH - *Hemophilia B MH - Infant PMC - PMC13318164 MID - NIHMS2174160 OTO - NOTNLM OT - Haemophilia A OT - Haemophilia B OT - haemarthrosis OT - joints OT - prophylaxis COIS- Beth Boulden Warren reports a relationship with Takeda Pharmaceuticals USA Inc and Sanofi that include consulting or advisory. Marilyn Manco-Johnson reports relationships with Genentech Inc and Roche that include consulting or advisory. Dianne Thornhill, Laura Singer-Fox, Julie Smith and Sharon Funk declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/14 12:35 MHDA- 2026/07/17 12:41 PMCR- 2026/07/17 CRDT- 2026/04/14 06:13 PHST- 2026/03/10 00:00 [revised] PHST- 2025/09/27 00:00 [received] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/07/17 12:41 [medline] PHST- 2026/04/14 12:35 [pubmed] PHST- 2026/04/14 06:13 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - HAE70283 [pii] AID - 10.1111/hae.70283 [doi] PST - ppublish SO - Haemophilia. 2026 Jul-Aug;32(4):1016-1024. doi: 10.1111/hae.70283. Epub 2026 Apr 14. PMID- 41978821 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260414 LR - 20260921 IS - 2328-8957 (Print) IS - 2328-8957 (Electronic) IS - 2328-8957 (Linking) VI - 13 IP - 4 DP - 2026 Apr TI - Interdisciplinary Pediatric Long-COVID Care: A Descriptive Study of Interventions and Health-Related Quality of Life. PG - ofag155 LID - 10.1093/ofid/ofag155 [doi] LID - ofag155 AB - OBJECTIVES: Data on pediatric long-COVID is limited to descriptive reports of symptom prevalence and incidence, with few studies describing integrative care or including patient-reported quality of life. This study describes demographic, clinical, symptom severity, and intervention characteristics within a pediatric long-COVID clinic involving collaboration between infectious disease and integrative medicine physicians. METHODS: Clinical data were extracted from the electronic health records for patients aged 4-25 with long-COVID seen within this clinic. A subset of patients completed validated PROs of wellbeing, fatigue, sleep-related impairment and disturbance, depression, and anxiety. RESULTS: A cohort of 214 patients (mean age 14.7, 61% female, 83% White) were seen between March 2021 and June 2023, with 39.7% providing Pediatric Quality of Life Inventory (PedsQL) and 30.3% providing Patient-Reported Outcomes Measurement Information System (PROMIS) measures. Common documented conditions included fatigue (85%), headache (75.2%), dizziness (64.5%), anxiety (62.1%), and nausea (59.3%). Common interventions included diet changes (81.8%), pacing (65.9%), sleep hygiene (61.2%), and other self-care techniques (46.7%). The long-COVID cohort reported elevated PROMIS sleep disturbance (61.79), sleep-related impairment (63.9), anxiety (58.1), and depression (58.1) as well as PedsQL total fatigue (40.19). These scores were more severe than national norms as well as compared with other pediatric chronic disease cohorts (eg, chronic pain, cancer, sickle cell disease, autism). CONCLUSIONS: Pediatric patients with long-COVID report high symptom burden. This study describes patient characteristics, care delivered and provides a novel description of symptom severity. Future research among more diverse populations is needed to evaluate outcomes of this integrative care. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Infectious Diseases Society of America. FAU - Miller, David W AU - Miller DW AD - Connor Whole Health, University Hospitals of Cleveland, Cleveland, Ohio, USA. AD - School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA. AD - Department of General Pediatrics, University Hospitals Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA. FAU - Rodgers-Melnick, Samuel N AU - Rodgers-Melnick SN AUID- ORCID: 0000-0003-0886-253X AD - Connor Whole Health, University Hospitals of Cleveland, Cleveland, Ohio, USA. AD - School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA. FAU - Deraz, Nada Tharwat AU - Deraz NT AUID- ORCID: 0009-0007-9622-5261 AD - School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA. AD - Department of General Pediatrics, University Hospitals Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA. FAU - Dusek, Jeffery A AU - Dusek JA AD - School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA. AD - Department of Medicine, University of CaliforniaIrvine, Irvine, California, USA. FAU - Segall, Tracy L AU - Segall TL AD - Connor Whole Health, University Hospitals of Cleveland, Cleveland, Ohio, USA. FAU - Edwards, Amy M AU - Edwards AM AUID- ORCID: 0009-0006-3287-1507 AD - School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA. AD - Department of General Pediatrics, University Hospitals Rainbow Babies and Children's Hospital, Cleveland, Ohio, USA. LA - eng PT - Journal Article DEP - 20260410 PL - United States TA - Open Forum Infect Dis JT - Open forum infectious diseases JID - 101637045 PMC - PMC13070613 OTO - NOTNLM OT - COVID-19 OT - fatigue OT - long-COVID OT - pediatrics COIS- Potential conflicts of interest. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. All authors: No reported conflicts of interest. EDAT- 2026/04/14 06:31 MHDA- 2026/04/14 06:32 PMCR- 2026/04/10 CRDT- 2026/04/14 04:07 PHST- 2025/04/04 00:00 [received] PHST- 2026/03/03 00:00 [accepted] PHST- 2026/04/14 06:32 [medline] PHST- 2026/04/14 06:31 [pubmed] PHST- 2026/04/14 04:07 [entrez] PHST- 2026/04/10 00:00 [pmc-release] AID - ofag155 [pii] AID - 10.1093/ofid/ofag155 [doi] PST - epublish SO - Open Forum Infect Dis. 2026 Apr 10;13(4):ofag155. doi: 10.1093/ofid/ofag155. eCollection 2026 Apr. PMID- 41978602 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260414 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 3 DP - 2026 Mar TI - Magnet-Assisted Anastomosis in Gastrointestinal Surgery: Current Evidence, Technical Considerations, and Barriers to Clinical Adoption. PG - e105175 LID - 10.7759/cureus.105175 [doi] LID - e105175 AB - Gastrointestinal (GI) anastomosis remains a cornerstone of abdominal surgery; however, anastomotic failure continues to represent a significant source of postoperative morbidity, mortality, and healthcare burden despite advances in suturing, stapling, and minimally invasive techniques. Magnet-assisted anastomosis (MAA) has recently re-emerged as an investigational, sutureless technique that utilizes sustained magnetic compression to induce localized ischemia, tissue necrosis, and subsequent biologic fusion of adjacent luminal surfaces without leaving permanent foreign material. Although early reports have demonstrated technical feasibility across select gastrointestinal, bariatric, and pediatric applications, the clinical evidence supporting MAA remains limited, heterogeneous, and largely confined to experimental studies and small clinical series. This qualitative narrative review critically synthesizes the available preclinical and early clinical literature to examine the mechanistic basis of MAA, current technical approaches, early feasibility outcomes, and the practical limitations that currently constrain broader clinical adoption. Particular attention is given to perioperative considerations unique to delayed anastomotic formation, including nutritional management, timing of luminal patency, device-related complications, and postoperative monitoring strategies. While preliminary studies report high technical success rates and successful formation of patent anastomoses in carefully selected patients, the existing literature remains constrained by small sample sizes, heterogeneous study designs, and limited long-term follow-up. Key questions regarding long-term durability, stricture formation, comparative leak risk, and standardized patient selection remain incompletely defined. By synthesizing the fragmented body of evidence on MAA, this review aims to clarify the current state of the field, identify critical knowledge gaps, and outline the research priorities needed to determine whether MAA can play a meaningful role in future gastrointestinal surgical practice. CI - Copyright (c) 2026, Salib et al. FAU - Salib, John AU - Salib J AD - School of Medicine, St. George's University, St. George's, GRD. FAU - Salib, Mark AU - Salib M AD - School of Medicine, St. George's University, St. George's, GRD. FAU - Kahlon, Aryan AU - Kahlon A AD - School of Medicine, St. George's University, St. George's, GRD. FAU - Sivakumar, Shanu AU - Sivakumar S AD - School of Medicine, St. George's University, St. George's, GRD. FAU - Stear, Timothy J AU - Stear TJ AD - Department of General Surgery, Community First Medical Center, Chicago, USA. AD - Department of General Surgery, Resurrection Medical Center, Chicago, USA. LA - eng PT - Journal Article PT - Review DEP - 20260313 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13070626 OTO - NOTNLM OT - device-based anastomosis OT - endoscopic anastomosis OT - gastrointestinal anastomosis OT - gastrointestinal reconstruction OT - hybrid endoscopic-surgical technique OT - magnet-assisted anastomosis OT - magnetic anastomosis OT - magnetic compression anastomosis OT - minimally invasive surgery OT - sutureless anastomosis COIS- Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/04/14 06:32 MHDA- 2026/04/14 06:33 PMCR- 2026/03/13 CRDT- 2026/04/14 04:04 PHST- 2026/03/13 00:00 [accepted] PHST- 2026/04/14 06:33 [medline] PHST- 2026/04/14 06:32 [pubmed] PHST- 2026/04/14 04:04 [entrez] PHST- 2026/03/13 00:00 [pmc-release] AID - 10.7759/cureus.105175 [doi] PST - epublish SO - Cureus. 2026 Mar 13;18(3):e105175. doi: 10.7759/cureus.105175. eCollection 2026 Mar. PMID- 41978368 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1460-6984 (Electronic) IS - 1368-2822 (Print) IS - 1368-2822 (Linking) VI - 61 IP - 3 DP - 2026 May-Jun TI - Investigation of Swallowing Performance and Family Impact in Children With Speech and Language Delay. PG - e70247 LID - 10.1111/1460-6984.70247 [doi] LID - e70247 AB - OBJECTIVE: This study aims to examine the relationship between delayed speech, feeding, and swallowing performance in children with speech and language delay (SLD) by comparing their feeding and swallowing performance with typically developing children, and to assess the impact of swallowing performance on families. METHODS: A total of 60 children aged 24-60 months whose mother language was Turkish and their families participated in the study. Participants were divided into two groups: 40 children diagnosed with SLD and 20 typically developing children. Swallowing performance were assessed using the Pediatric Eating Assessment Tool (PEDI EAT-10), the Oral Speech Mechanism Screening Examination-Third Edition (OSMSE-3), and the Karaduman Chewing Performance Scale (KCPS). Nutritional status was assessed using the Functional Oral Intake Scale (FOIS), while family impact was measured using the Pediatric Quality of Life Inventory (PedsQL) and the Feeding/Swallowing Impact Survey (FS-IS). RESULTS: Results showed significant differences between the two groups in PEDI-EAT-10, OSMSE-3, and KCPS scores. The SLD group demonstrated significantly higher PEDI-EAT-10 scores (1.60 +/- 4.21) compared with the typically developing control (TDC) group (0.00 +/- 0.00; p = 0.011). Similarly, KCPS scores were significantly elevated in the SLD group (0.60 +/- 0.59) relative to the TDC group (0.05 +/- 0.22; p = 0.001). In contrast, the total OSMSE-3 score was significantly lower in the SLD group (40.40 +/- 7.49) than in the TDC group (48.80 +/- 2.07; p < 0.001), indicating poorer oral sensorimotor function among children with SLD. However, no significant difference was found in FOIS scores (p = 0.058). Regarding family impact, significant differences were observed in PedsQL and FS-IS scores (p = 0.001; p = 0.044). CONCLUSION: In conclusion, the swallowing performance and oral motor function of children with SLD were found to be significantly different from children without SLD. This suggests a possible association between motor planning deficits and the co-occurrence of speech and language disorders and swallowing dysfunction. In addition, families of children with SLD reported lower quality of life and greater concerns about feeding and swallowing. These findings underscore the importance of addressing both SLD and swallowing disorder concurrently in clinical practice. WHAT THIS PAPER ADDS: What is already known on this subject Speech and language delay (SLD) is among the most common developmental disorders in early childhood and often co-occurs with feeding and swallowing difficulties. Both speech and swallowing rely on shared neuromuscular and motor planning processes, suggesting a potential link between the two. Previous studies indicate that early feeding/swallowing challenges may serve as risk indicators for later language impairments. However, existing research has primarily focused on communication and learning outcomes, with limited attention given to swallowing performance in children with isolated SLD and the psychosocial impact on their families. What this paper adds to the existing knowledge This study demonstrates that children with SLD exhibit significantly poorer swallowing performance and oral motor function compared to typically developing peers, despite showing no clinically significant nutritional limitations. It also highlights that families of children with SLD experience lower quality of life and greater daily challenges related to feeding and swallowing. By excluding confounding conditions such as neurological disorders and autism, this study provides clearer evidence of the association between SLD and swallowing dysfunction, as well as its negative impact on families-an area that has been largely underexplored in the literature. What are the potential or actual clinical implications of this study? The findings underscore the need for clinicians to assess swallowing and oral motor skills in children presenting with SLD, even when overt feeding problems are not reported. Early identification of swallowing difficulties can support timely interventions that may mitigate developmental challenges. Moreover, given the demonstrated impact on families, clinical management should incorporate caregiver support and family-centered approaches. Integrating swallowing assessments into routine SLD evaluations could improve diagnostic accuracy, guide multidisciplinary interventions, and ultimately enhance both child outcomes and family quality of life. CI - (c) 2026 The Author(s). International Journal of Language & Communication Disorders published by John Wiley & Sons Ltd on behalf of Royal College of Speech and Language Therapists. FAU - Koca, Fahri AU - Koca F AUID- ORCID: 0009-0003-7264-2133 AD - Department of Speech and Language Therapy, Faculty of Health Sciences, Istanbul Atlas University, Istanbul, Turkey. FAU - Bengisu, Serkan AU - Bengisu S AUID- ORCID: 0000-0002-6580-1189 AD - Department of Speech and Language Therapy, Faculty of Health Sciences, Istanbul Atlas University, Istanbul, Turkey. FAU - Demir, Numan AU - Demir N AUID- ORCID: 0000-0001-6308-0237 AD - Hacettepe University Faculty of Physical Therapy and Rehabilitation, Ankara, Turkey. LA - eng PT - Journal Article PL - United States TA - Int J Lang Commun Disord JT - International journal of language & communication disorders JID - 9803709 SB - IM MH - Humans MH - Male MH - Female MH - Child, Preschool MH - *Language Development Disorders/psychology/physiopathology/complications/diagnosis MH - *Deglutition Disorders/psychology/diagnosis MH - Quality of Life MH - *Deglutition/physiology MH - Mastication MH - Turkey MH - Nutritional Status PMC - PMC13077260 OTO - NOTNLM OT - family quality of life OT - feeding and swallowing difficulties OT - feeding performance OT - oral motor functions OT - speech and language disorders OT - swallowing disorders EDAT- 2026/04/14 06:32 MHDA- 2026/04/14 06:33 PMCR- 2026/04/14 CRDT- 2026/04/14 02:53 PHST- 2026/03/07 00:00 [revised] PHST- 2025/08/25 00:00 [received] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/04/14 06:33 [medline] PHST- 2026/04/14 06:32 [pubmed] PHST- 2026/04/14 02:53 [entrez] PHST- 2026/04/14 00:00 [pmc-release] AID - JLCD70247 [pii] AID - 10.1111/1460-6984.70247 [doi] PST - ppublish SO - Int J Lang Commun Disord. 2026 May-Jun;61(3):e70247. doi: 10.1111/1460-6984.70247. PMID- 41978199 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 7 DP - 2026 Apr 3 TI - Sustainable Eating in Saudi Arabia: Associations Between Food Sustainability Knowledge, Attitudes, Food Waste-Related Behaviours, and Dietary Choices Among Adults. LID - 10.3390/nu18071149 [doi] LID - 1149 AB - Background/Objectives: Sustainable food habits are essential for reducing the environmental impacts of a food system. We investigated food sustainability knowledge, attitudes, and food waste-related behaviours among Saudi adults and assessed their associations with socio-demographic characteristics and dietary choices, which are subjects that remain under-researched. Methods: A cross-sectional study was conducted among 855 Saudi adults (>/=18 years) using convenience sampling. Data were collected using a validated online questionnaire assessing sustainability knowledge, attitudes, food waste behaviours, dietary choices, and socio-demographic characteristics. Descriptive statistics, chi-square tests, and linear regression analyses were performed using SPSS version 29. Results: Overall, 32% of the study population demonstrated adequate sustainability knowledge, 61% expressed positive attitudes towards food sustainability, and 45% demonstrated favourable food waste management. Women were more knowledgeable than men. Participants who possessed a better understanding of food sustainability consumed more vegetables, fruits, and bread and less processed meat. Those with a positive attitude towards food sustainability exhibited higher consumption of red meat, white meat, eggs, milk, yogurt, cheese, vegetables, fruits, bread, and sweet or savoury snacks. Meanwhile, individuals with better food waste behaviours demonstrated significantly lower consumption of legumes, fish, pasta, red meat, white meat, processed meat, eggs, milk, yogurt, cheese, fruits, bread, and sweet or savoury snacks. Conclusions: Saudi adults possess limited knowledge of sustainability and suboptimal food waste behaviours despite having relatively positive attitudes. These findings highlight opportunities for intervention. Public education, targeted campaigns, and media communication could enhance sustainability awareness and promote healthier, environmentally sustainable dietary patterns. FAU - Alghamdi, Areej A AU - Alghamdi AA AUID- ORCID: 0009-0003-4269-1719 AD - Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah 22254, Saudi Arabia. FAU - Aljefree, Najlaa M AU - Aljefree NM AUID- ORCID: 0000-0001-9598-7140 AD - Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah 22254, Saudi Arabia. FAU - Shatwan, Israa M AU - Shatwan IM AUID- ORCID: 0000-0003-0222-9135 AD - Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah 22254, Saudi Arabia. FAU - Almoraie, Noha M AU - Almoraie NM AUID- ORCID: 0000-0002-2212-1255 AD - Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah 22254, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260403 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Food Loss and Waste) SB - IM MH - Humans MH - Saudi Arabia MH - Male MH - Female MH - *Health Knowledge, Attitudes, Practice MH - Adult MH - Cross-Sectional Studies MH - Food Loss and Waste MH - Middle Aged MH - *Feeding Behavior MH - Young Adult MH - *Diet MH - *Food Preferences MH - Adolescent MH - Surveys and Questionnaires MH - *Choice Behavior PMC - PMC13075233 OTO - NOTNLM OT - attitude OT - behaviour OT - dietary choices OT - knowledge OT - sustainable food habits COIS- The authors declare no conflicts of interest. EDAT- 2026/04/14 06:31 MHDA- 2026/04/14 06:32 PMCR- 2026/04/03 CRDT- 2026/04/14 01:11 PHST- 2026/01/31 00:00 [received] PHST- 2026/03/24 00:00 [revised] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/04/14 06:32 [medline] PHST- 2026/04/14 06:31 [pubmed] PHST- 2026/04/14 01:11 [entrez] PHST- 2026/04/03 00:00 [pmc-release] AID - nu18071149 [pii] AID - nutrients-18-01149 [pii] AID - 10.3390/nu18071149 [doi] PST - epublish SO - Nutrients. 2026 Apr 3;18(7):1149. doi: 10.3390/nu18071149. PMID- 41978182 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 7 DP - 2026 Mar 31 TI - Measuring the Ecological Footprint of Eating Behaviors: A Psychometric Study on the Turkish Version of the EREC Scale. LID - 10.3390/nu18071132 [doi] LID - 1132 AB - BACKGROUND/OBJECTIVES: This study was conducted to determine the validity and reliability of the Eating-Related Eco-Concern (EREC) in young Turkish adults and to evaluate the effect of ecological concerns on disordered eating characteristics, with a view to comparing these effects with the risk of eating disorders. METHODS: The study included 600 young adults (138 males and 462 females) aged 18 to 35. Using face-to-face administration, the Eating Disorder Examination Questionnaire (EDE-Q-13) Short Form to assess eating disorder-related psychopathology and the EREC Scale to assess eating behaviors related to eco-concern were administered, and Turkish validity and reliability were examined. RESULTS: The Kaiser-Meyer-Olkin (KMO) was 0.801, signifying acceptable sample adequacy, while Bartlett's test of sphericity was significant (chi(2) = 636.159, p < 0.001). All item factor loadings ranged from 0.582 to 0.767 and were statistically significant (p < 0.001). The scale's Cronbach's alpha was 0.854. Test-retest reliability was good, with an infraclass correlation coefficient (ICC) of 0.811 95% CI. The analysis revealed that the single-factor model demonstrated an acceptable fit to the data (chi(2)/df = 2.84, CFI = 0.976). There was no statistically significant correlation between EREC and the total EDE-Q-13 score (p = 0.064). On the other hand, the total EDE-Q-13 score was identified as a significant negative predictor of EREC scores (beta = -2.648, p = 0.028). CONCLUSIONS: All item factors of the Turkish adaptation of the scale exhibit a structure that is quite consistent with the original scale. The 10-question version of EREC can be used with young adults in Turkiye. In this study, although ecological anxiety was associated with eating restraint or purging, it was not found to be generally associated with eating disorders. FAU - Ayhan, Busra AU - Ayhan B AUID- ORCID: 0000-0001-8617-8552 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06490, Turkiye. FAU - Govez, Nazlican Erdogan AU - Govez NE AUID- ORCID: 0000-0003-2969-4109 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06490, Turkiye. FAU - Bilici, Saniye AU - Bilici S AUID- ORCID: 0000-0002-1235-0329 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06490, Turkiye. FAU - Koksal, Eda AU - Koksal E AUID- ORCID: 0000-0002-7930-9910 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06490, Turkiye. FAU - Tekin, Nasminel AU - Tekin N AUID- ORCID: 0009-0001-4163-1867 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Gazi University, Ankara 06490, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20260331 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Turkey MH - Female MH - *Psychometrics MH - Reproducibility of Results MH - *Feeding Behavior/psychology MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Male MH - Young Adult MH - Adult MH - Surveys and Questionnaires MH - Adolescent PMC - PMC13074659 OTO - NOTNLM OT - EDE-Q-13 OT - EREC OT - eating behavior OT - eco-concern OT - validation COIS- The authors declare no conflicts of interest. EDAT- 2026/04/14 06:31 MHDA- 2026/04/14 06:32 PMCR- 2026/03/31 CRDT- 2026/04/14 01:11 PHST- 2026/02/19 00:00 [received] PHST- 2026/03/24 00:00 [revised] PHST- 2026/03/26 00:00 [accepted] PHST- 2026/04/14 06:32 [medline] PHST- 2026/04/14 06:31 [pubmed] PHST- 2026/04/14 01:11 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - nu18071132 [pii] AID - nutrients-18-01132 [pii] AID - 10.3390/nu18071132 [doi] PST - epublish SO - Nutrients. 2026 Mar 31;18(7):1132. doi: 10.3390/nu18071132. PMID- 41978179 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 7 DP - 2026 Mar 31 TI - Association Between Mineral Intake and Cognitive Performance in Spanish Adults with Overweight and Obesity: A Cross-Sectional Study. LID - 10.3390/nu18071129 [doi] LID - 1129 AB - Background/Objectives: While adequate mineral intake is essential for brain health and cognitive function across the lifespan, the potential impact of excessive consumption remains underexplored. This study aimed to examine the association between dietary intake of selected minerals, with particular focus on iron and zinc, and cognitive performance in Spanish adults with obesity, particularly in executive-related domains such as reasoning, cognitive flexibility, and working memory. Methods: A cross-sectional study was conducted in 230 Spanish adults (18-65 years) from the Tech4Diet-Person project. Sociodemographic, dietary, and cognitive data were collected between 2021 and 2024. Cognitive function was assessed using the validated computerized CogniFit battery, and mineral intake was estimated through a food frequency questionnaire (93 items). Individuals with neurological, metabolic, or psychiatric disorders, as well as pregnant or lactating women, were excluded. Results: Participants had a mean age of 45.91 (+/-9.92) years. Nominal differences in mineral intake were observed across specific executive cognitive domains. Higher dietary iron intake was associated with lower performance in reasoning and cognitive flexibility, while higher zinc intake was associated with lower working memory performance. In adjusted logistic regression models, higher iron intake was independently associated with increased odds of low reasoning performance (OR = 1.25; p = 0.006), and higher zinc intake was associated with increased odds of low working memory performance (OR = 1.36; p = 0.024), after controlling for age, educational level, BMI, and total energy intake. Conclusions: Higher self-reported intake of iron and zinc showed nominal associations with lower performance in specific executive domains. These findings should be considered exploratory and require confirmation in longitudinal and biomarker-based studies. FAU - Tome-Fernandez, Mario AU - Tome-Fernandez M AUID- ORCID: 0009-0009-1471-8260 AD - Department of Health Psychology, Faculty of Health Science, University of Alicante, 03690 Alicante, Spain. FAU - Martin-Manchado, Laura AU - Martin-Manchado L AUID- ORCID: 0009-0009-4889-4967 AD - Department of Nursing, Faculty of Health Science, University of Alicante, 03690 Alicante, Spain. FAU - Sanchez-Sansegundo, Miriam AU - Sanchez-Sansegundo M AUID- ORCID: 0000-0003-2114-6503 AD - Department of Health Psychology, Faculty of Health Science, University of Alicante, 03690 Alicante, Spain. AD - Alicante Health and Biomedical Research Institute, ISABIAL Foundation, 03010 Alicante, Spain. FAU - Zaragoza-Marti, Ana AU - Zaragoza-Marti A AUID- ORCID: 0000-0001-8865-2326 AD - Department of Nursing, Faculty of Health Science, University of Alicante, 03690 Alicante, Spain. AD - Alicante Health and Biomedical Research Institute, ISABIAL Foundation, 03010 Alicante, Spain. FAU - Azorin-Lopez, Jorge AU - Azorin-Lopez J AUID- ORCID: 0000-0003-4762-6927 AD - Department of Computer Science and Technology, University of Alicante, 03690 Alicante, Spain. FAU - Hurtado-Sanchez, Jose Antonio AU - Hurtado-Sanchez JA AUID- ORCID: 0000-0002-6363-2385 AD - Department of Health Psychology, Faculty of Health Science, University of Alicante, 03690 Alicante, Spain. AD - Alicante Health and Biomedical Research Institute, ISABIAL Foundation, 03010 Alicante, Spain. LA - eng GR - PID2023-149562OB-I00/Ministry of Science, Innovation and Universities/ PT - Journal Article DEP - 20260331 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - J41CSQ7QDS (Zinc) RN - 0 (Minerals) SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Middle Aged MH - Adult MH - Male MH - Spain MH - *Cognition MH - *Obesity/psychology MH - *Overweight/psychology MH - Young Adult MH - Adolescent MH - Zinc/administration & dosage MH - Executive Function MH - Cognitive Flexibility MH - Aged MH - Memory, Short-Term MH - *Diet MH - *Minerals/administration & dosage PMC - PMC13075055 OTO - NOTNLM OT - cognitive performance OT - executive function OT - iron OT - micronutrients OT - mineral intake OT - nutrition OT - zinc COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/04/14 06:32 MHDA- 2026/04/14 06:33 PMCR- 2026/03/31 CRDT- 2026/04/14 01:11 PHST- 2026/02/20 00:00 [received] PHST- 2026/03/26 00:00 [revised] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/04/14 06:33 [medline] PHST- 2026/04/14 06:32 [pubmed] PHST- 2026/04/14 01:11 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - nu18071129 [pii] AID - nutrients-18-01129 [pii] AID - 10.3390/nu18071129 [doi] PST - epublish SO - Nutrients. 2026 Mar 31;18(7):1129. doi: 10.3390/nu18071129. PMID- 41978166 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260818 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 7 DP - 2026 Mar 31 TI - Lifetime Soy Intake and Adult Mammographic Density in Chinese Premenopausal Women. LID - 10.3390/nu18071116 [doi] LID - 1116 AB - Background: Soy intake has been proposed as a protective factor for breast cancer, especially when exposure occurs early in life. Mammographic density (MD) is a strong predictor of breast cancer risk, but evidence linking soy intake at specific life stages to adult mammographic density remains limited. Objective: The objective of this study was to evaluate the associations between dietary soy intake at different life stages and MD in premenopausal Chinese women. Methods: Dietary soy intake was assessed using a validated soy food frequency questionnaire for the past 12 months and retrospectively for earlier life stages (childhood: 6-12 years; adolescence: 13-18 years; young adulthood: 20-34 years), with recall aided by a life history calendar. MD was measured from bilateral cranio-caudal mammograms using a standardized computer-assisted method. Multivariable regression models were used to evaluate associations between soy protein and isoflavone intake at different life stages and MD, adjusting for relevant confounders. Results: Among 815 premenopausal women (mean age 40.9 y), mean current soy protein and isoflavone intakes were 10.3 g/day and 22.0 mg/day, respectively. Soy intakes across life stages were moderately correlated (r = 0.33-0.81). After multivariable adjustment, soy protein intake during adolescence (beta = -0.067, SE = 0.029, p = 0.023) and childhood (beta = -0.071, SE = 0.032, p = 0.028) was significantly and inversely associated with adult MD. Young adult intake showed a non-significant inverse trend (beta = -0.052, p = 0.075), and current intake showed no association (p = 0.93). Higher mean early-life (ages 6-18) and life course soy intakes were also inversely associated with MD (beta range: -0.077 to -0.082; all p < 0.05). Women with consistently high early-life soy intake had 5.8-6.6% lower adjusted MD than those with consistently low intake. Conclusions: Early-life soy exposure may influence adult breast tissue composition and represents a potentially modifiable protective factor in breast cancer prevention. These findings carry important public health implications, particularly for populations experiencing dietary westernization. FAU - Ho, Suzanne C AU - Ho SC AUID- ORCID: 0000-0001-5232-2886 AD - JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China. FAU - Boyd, Norman F AU - Boyd NF AD - Princess Margaret Cancer Centre and Imaging Research, University of Toronto, Toronto, ON M5S 3G8, Canada. FAU - Tam, Wilson W S AU - Tam WWS AUID- ORCID: 0000-0003-0641-3060 AD - Alice Lee Centre for Nursing Studies, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore. FAU - Yeo, Winnie AU - Yeo W AUID- ORCID: 0000-0002-0863-8469 AD - Department of Clinical Oncology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China. FAU - Chu, Winnie C W AU - Chu WCW AUID- ORCID: 0000-0003-4962-4132 AD - Department of Imaging and Interventional Radiology, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China. FAU - So, Edwina K F AU - So EKF AD - JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China. FAU - Yu, Ruby AU - Yu R AUID- ORCID: 0000-0001-7051-4689 AD - JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China. FAU - Woo, Jean AU - Woo J AUID- ORCID: 0000-0001-7593-3081 AD - Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong 999077, China. LA - eng GR - 2003/81/World Cancer Research Fund International/ PT - Journal Article DEP - 20260331 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Soybean Proteins) RN - 0 (Isoflavones) RN - Chinese people SB - IM MH - Humans MH - Female MH - Adult MH - *Premenopause MH - *Breast Density MH - Adolescent MH - China MH - Young Adult MH - *Soybean Proteins/administration & dosage MH - *Soy Foods MH - *Breast Neoplasms/prevention & control MH - Retrospective Studies MH - Child MH - Mammography MH - *Diet MH - Isoflavones/administration & dosage MH - Risk Factors MH - Middle Aged MH - East Asian People PMC - PMC13074378 OTO - NOTNLM OT - Chinese premenopausal women OT - life course exposure OT - mammographic density OT - soy protein COIS- The authors declare no conflicts of interest. EDAT- 2026/04/14 06:32 MHDA- 2026/04/14 06:33 PMCR- 2026/03/31 CRDT- 2026/04/14 01:11 PHST- 2026/03/02 00:00 [received] PHST- 2026/03/19 00:00 [revised] PHST- 2026/03/28 00:00 [accepted] PHST- 2026/04/14 06:33 [medline] PHST- 2026/04/14 06:32 [pubmed] PHST- 2026/04/14 01:11 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - nu18071116 [pii] AID - nutrients-18-01116 [pii] AID - 10.3390/nu18071116 [doi] PST - epublish SO - Nutrients. 2026 Mar 31;18(7):1116. doi: 10.3390/nu18071116. PMID- 41978161 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 7 DP - 2026 Mar 30 TI - Establish Global Nutrition Research Strategies: The Meeting Report of the First SIOP Nutrition Research Forum. LID - 10.3390/nu18071112 [doi] LID - 1112 AB - Despite strong evidence linking nutritional status to treatment efficacy and survival in pediatric cancer, significant knowledge gaps and practice variation persist globally. On 24th October 2025, the International Society of Paediatric Oncology (SIOP) Nutrition Network, in collaboration with Prinsess Maxima Center for Paediatric Oncology and the International Initiative for Pediatrics and Nutrition (IIPAN), convened the first global SIOP Nutrition Network Research Forum. The forum brought together 54 international experts from high-income countries and low- and middle-income countries to define global nutrition research strategies for pediatric oncology. The forum addressed six emerging domains: body composition and treatment outcomes; microbiome, micronutrient status and metabolic health; prehabilitation and rehabilitation strategies; validation of nutritional assessment tools, guideline development for high-income settings; insights from international multicentric research initiatives-the International Atomic Energy Agency (IAEA), SIOP Nutrition Network, the Adapted Resource and Implementation Application (ARIA) guide nutrition portal, the International Collaboration on Nutrition in Cancer (ICONIC) WHO knowledge portal; and IIPAN and the World Cancer Research Fund (WCRF) for funding strategies. Delegates identified three priority working groups, namely prehabilitation optimization, pharmacokinetics, and advocacy, with each outlining collaborative nutrition research priorities for the next five years. This forum represents a critical point in pediatric oncology nutrition research as it established the first coordinated and internationally endorsed roadmap to bridge gaps in cancer care and ensure standard nutrition care worldwide. The research priorities and collaborations will help in creating evidence to improve cancer treatment and survival rate for children globally. FAU - Gala, Rajul M AU - Gala RM AUID- ORCID: 0009-0006-3365-1143 AD - Division of Paediatric Oncology, Tata Memorial Centre, Mumbai 400 012, India. FAU - Schoeman, Judy AU - Schoeman J AUID- ORCID: 0000-0002-6154-3653 AD - Division of Paediatric Oncology and Haematology, Department of Paediatrics and Child Health, Faculty of Medicine and Health Sciences, University of Pretoria, Pretoria 0001, South Africa. AD - Department of Pediatrics and Child Health, Faculty of Medicine and Health Science, Stellenbosch University, Stellenbosch 7505, South Africa. FAU - Revuelta Iniesta, Raquel AU - Revuelta Iniesta R AUID- ORCID: 0000-0002-5534-7146 AD - Public Health and Sports Sciences, Faculty of Life and Health Sciences, Medical School, University of Exeter, Exeter EX2 4TE, UK. AD - Child Life and Health, University of Edinburgh, Edinburgh EH16 4TJ, UK. FAU - van den Brink, Mirjam AU - van den Brink M AUID- ORCID: 0000-0001-6758-8978 AD - Princess Maxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands. FAU - Lovell, Amy L AU - Lovell AL AUID- ORCID: 0000-0002-1708-9633 AD - Department of Nutrition and Dietetics, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand. AD - Starship Blood and Cancer Centre, Starship Child Health, Te Whatu Ora, Te Toka Tumai, Auckland 1142, New Zealand. FAU - Huibers, Minke H W AU - Huibers MHW AUID- ORCID: 0000-0003-0310-3067 AD - Department of Pediatrics and Child Health, Faculty of Medicine and Health Science, Stellenbosch University, Stellenbosch 7505, South Africa. AD - Princess Maxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands. AD - Global Child Health Group, Amsterdam University Centre, 1100 DD Amsterdam, The Netherlands. CN - SIOP Nutrition Network Research Forum LA - eng PT - Conference Proceedings DEP - 20260330 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Child MH - Humans MH - *Biomedical Research MH - Global Health MH - Medical Oncology MH - *Neoplasms/therapy MH - Nutrition Assessment MH - Nutritional Status MH - *Pediatrics PMC - PMC13075039 OTO - NOTNLM OT - cancer in children OT - meeting report OT - nutrition OT - nutrition research forum OT - pediatric oncology COIS- The authors declare no conflicts of interest, and the funders of the meeting had no role in the planning or finalizing of the agenda of the Nutrition Research Forum Meeting; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/04/14 06:31 MHDA- 2026/04/14 06:32 PMCR- 2026/03/30 CRDT- 2026/04/14 01:11 PHST- 2026/02/09 00:00 [received] PHST- 2026/03/20 00:00 [revised] PHST- 2026/03/26 00:00 [accepted] PHST- 2026/04/14 06:32 [medline] PHST- 2026/04/14 06:31 [pubmed] PHST- 2026/04/14 01:11 [entrez] PHST- 2026/03/30 00:00 [pmc-release] AID - nu18071112 [pii] AID - nutrients-18-01112 [pii] AID - 10.3390/nu18071112 [doi] PST - epublish SO - Nutrients. 2026 Mar 30;18(7):1112. doi: 10.3390/nu18071112. PMID- 41978134 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 7 DP - 2026 Mar 28 TI - Firmicutes/Bacteroidetes Ratio as an Insufficient Indicator of Metabolic Status in Mexican Young Adults. LID - 10.3390/nu18071084 [doi] LID - 1084 AB - Background: The Firmicutes/Bacteroidetes (F/B) ratio has been proposed as a microbial biomarker of obesity and metabolic alterations; however, its reliability remains controversial, particularly in young populations. Methods: This study evaluated the relationship between the F/B ratio, body fat percentage, and metabolic markers in 70 university students aged 18-25 years, classified as normal weight (29.5%), overweight (27.4%), or obese (43.2%). Anthropometric measurements and biochemical parameters (glucose, triglycerides, total cholesterol, and HDL-C) were obtained using standard methods, and stool samples were analyzed to determine the F/B ratio. Results: Mean glucose and cholesterol were within normal ranges, whereas triglycerides showed high variability, and HDL-C was lower in men. Although the F/B ratio increased across nutritional groups, regression analyses showed weak correlations (R < 0.5) and no significant associations (p > 0.05). Conclusions: The F/B ratio is not an adequate standalone indicator of metabolic status in Mexican young adults. FAU - Nez-Castro, Ana Teresa AU - Nez-Castro AT AUID- ORCID: 0000-0002-7530-7336 AD - Instituto de Ciencias de la Salud, Area Academica de Nutricion, Universidad Autonoma del Estado de Hidalgo, Circuito Ex Hacienda, La Concepcion S/N, Carretera Pachuca Actopan, San Agustin Tlaxiaca 42060, Hidalgo, Mexico. FAU - Gonzalez-Olivares, Luis Guillermo AU - Gonzalez-Olivares LG AUID- ORCID: 0000-0002-4707-8935 AD - Instituto de Ciencias Basicas e Ingenieria, Area Academica de Quimica, Universidad Autonoma del Estado de Hidalgo, Carr. Pachuca-Tulancingo km. 4.5, Pachuca 42184, Hidalgo, Mexico. FAU - Olvera-Rosales, Laura Berenice AU - Olvera-Rosales LB AUID- ORCID: 0009-0009-8603-9048 AD - Instituto de Ciencias Basicas e Ingenieria, Area Academica de Quimica, Universidad Autonoma del Estado de Hidalgo, Carr. Pachuca-Tulancingo km. 4.5, Pachuca 42184, Hidalgo, Mexico. FAU - Barron-Calva, Edwin Gualberto AU - Barron-Calva EG AUID- ORCID: 0000-0001-6581-7298 AD - Instituto de Ciencias Sociales y Humanidades, Area Academica de Sociologia y Demografia, Universidad Autonoma del Estado de Hidalgo, Carr. Pachuca-Actopan km. 4.5 S/N, Pachuca 42084, Hidalgo, Mexico. FAU - Chavez-Mejia, Edwin Alonso AU - Chavez-Mejia EA AUID- ORCID: 0009-0003-4375-0928 AD - Instituto de Ciencias de la Salud, Area Academica de Medicina, Universidad Autonoma del Estado de Hidalgo, Circuito Ex Hacienda, La Concepcion S/N, Carretera Pachuca Actopan, San Agustin Tlaxiaca 42060, Hidalgo, Mexico. FAU - Omana-Covarrubias, Arianna AU - Omana-Covarrubias A AUID- ORCID: 0000-0002-8649-8617 AD - Instituto de Ciencias de la Salud, Area Academica de Nutricion, Universidad Autonoma del Estado de Hidalgo, Circuito Ex Hacienda, La Concepcion S/N, Carretera Pachuca Actopan, San Agustin Tlaxiaca 42060, Hidalgo, Mexico. FAU - Franco-Abuin, Carlos Manuel AU - Franco-Abuin CM AUID- ORCID: 0000-0001-8823-5522 AD - Laboratorio de Higiene, Inspeccion y Control de Alimentos, Departamento de Quimica Analitica, Nutricion y Bromatologia, Campus Terra, Universidade da Santiago de Compostela, 27002 Lugo, Spain. FAU - Mondragon-Portocarrero, Alicia Del Carmen AU - Mondragon-Portocarrero ADC AUID- ORCID: 0000-0003-1274-5539 AD - Laboratorio de Higiene, Inspeccion y Control de Alimentos, Departamento de Quimica Analitica, Nutricion y Bromatologia, Campus Terra, Universidade da Santiago de Compostela, 27002 Lugo, Spain. LA - eng PT - Journal Article DEP - 20260328 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) RN - 0 (Triglycerides) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Male MH - Mexico MH - Young Adult MH - Adolescent MH - Adult MH - Biomarkers/blood MH - *Bacillota/isolation & purification MH - Female MH - *Obesity/microbiology MH - Triglycerides/blood MH - Feces/microbiology MH - Overweight/microbiology MH - Blood Glucose/metabolism PMC - PMC13074922 OTO - NOTNLM OT - Firmicutes/Bacteroidetes ratio OT - body fat percentage OT - intestinal microbiota OT - metabolic indicators COIS- The authors declare no conflicts of interest. EDAT- 2026/04/14 06:31 MHDA- 2026/04/14 06:32 PMCR- 2026/03/28 CRDT- 2026/04/14 01:11 PHST- 2026/02/20 00:00 [received] PHST- 2026/03/25 00:00 [revised] PHST- 2026/03/26 00:00 [accepted] PHST- 2026/04/14 06:32 [medline] PHST- 2026/04/14 06:31 [pubmed] PHST- 2026/04/14 01:11 [entrez] PHST- 2026/03/28 00:00 [pmc-release] AID - nu18071084 [pii] AID - nutrients-18-01084 [pii] AID - 10.3390/nu18071084 [doi] PST - epublish SO - Nutrients. 2026 Mar 28;18(7):1084. doi: 10.3390/nu18071084. PMID- 41978088 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 7 DP - 2026 Mar 25 TI - Family Eating Habits and Dietary Quality of Spanish Children and Adolescents: The PASOS Study. LID - 10.3390/nu18071038 [doi] LID - 1038 AB - Background: Childhood nutrition is essential for development and disease prevention. Parental dietary practices and sociodemographic factors shape children's eating habits. Objective: To assess the association between parental diet quality, children's diet, and nutritional status, as well as the influence of caregiver sociodemographic factors. Design: Cross-sectional analyses were conducted using data from two waves of the PASOS study (2019-2020 and 2022-2023), which are nationally representative multicentre observational surveys. The analyses were restricted to participants with complete information on parental diet quality, children's diet quality, and relevant covariates. Methods: Participants aged 8-16 years from the PASOS 2019-2020 (n = 1028) and 2022-2023 (n = 572) studies were included. Caregivers provided sociodemographic information and completed the Short Diet Quality Screener (SDQS), a validated questionnaire to assess parental diet quality. Children's diet quality was assessed using the validated KIDMED index. Based on parental SDQS scores, participants were classified into low (50th percentile) diet quality groups. Associations were analysed using logistic regression and Pearson correlation. Results: Higher parental diet quality was consistently associated with greater adherence to the Mediterranean diet and higher consumption of fruit, breakfast cereals, and fish among children in both study waves. Children whose caregivers had better diet quality also showed a lower prevalence of abdominal obesity. Parental diet quality was positively associated with children's diet quality and inversely related to several adiposity indicators, although associations with anthropometric measures were generally weak. Conclusions: Family-based approaches are essential for improving diet quality and preventing childhood obesity. FAU - Rodenas-Munar, Marina AU - Rodenas-Munar M AUID- ORCID: 0009-0009-0954-039X AD - Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain. FAU - Garcia, Silvia AU - Garcia S AUID- ORCID: 0000-0003-3534-1588 AD - Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain. FAU - Gomez, Santiago F AU - Gomez SF AUID- ORCID: 0000-0003-3352-2510 AD - Gasol Foundation Europe, 08830 Sant Boi de Llobregat, Spain. AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Institute for Medical Research, 08003 Barcelona, Spain. AD - Nursing and Physiotherapy Department, University of Lleida, 25198 Lleida, Spain. FAU - Gonzalez-Gross, Marcela AU - Gonzalez-Gross M AUID- ORCID: 0000-0001-7757-3235 AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. AD - ImFINE Research Group, Department of Health and Human Performance, Universidad Politecnica de Madrid, 28040 Madrid, Spain. FAU - Warnberg, Julia AU - Warnberg J AUID- ORCID: 0000-0002-8408-316X AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. AD - EpiPHAAN Research Group, Faculty of Health Sciences, Universidad de Malaga-Instituto de Investigacion Biomedica de Malaga (IBIMA Bionand), 28590 Malaga, Spain. FAU - Gusi, Narcis AU - Gusi N AUID- ORCID: 0000-0002-1001-8883 AD - Physical Activity and Quality of Life Research Group (AFYCAV), Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. AD - Instituto de Investigacion e Innovacion en el Deporte (INIDE), 10003 Caceres, Spain. FAU - Aznar, Susana AU - Aznar S AUID- ORCID: 0000-0001-7054-436X AD - PAFS Research Group, Faculty of Sports Sciences, University of Castilla-La Mancha-Toledo Campus, 45071 Toledo, Spain. FAU - Marin-Cascales, Elena AU - Marin-Cascales E AD - UCAM Research Center for High Performance Sport, Universidad Catolica de Murcia, 30107 Murcia, Spain. AD - Faculty of Sport, Universidad Catolica de Murcia, 30107 Murcia, Spain. FAU - Gonzalez-Valeiro, Miguel Angel AU - Gonzalez-Valeiro MA AUID- ORCID: 0000-0002-3993-8069 AD - Faculty of Sports Sciences and Physical Education, Universidade da Coruna, 15071 A Coruna, Spain. FAU - Pulgar, Susana AU - Pulgar S AUID- ORCID: 0000-0002-6845-248X AD - Regional Unit of Sports Medicine of Principado de Asturias, Fundacion Deportiva Municipal de Aviles, 33401 Aviles, Spain. FAU - Bautista, Inmaculada AU - Bautista I AUID- ORCID: 0000-0001-9257-8739 AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. AD - Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, 35016 Las Palmas, Spain. AD - Preventive Medicine Service, Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health Service, 35016 Las Palmas, Spain. FAU - Oses, Maddi AU - Oses M AD - ELIKOS Group, Institute for Sustainability and Food Chain Innovation (IS-FOOD), Department of Health Sciences, Public University of Navarre, 31006 Pamplona, Spain. FAU - Cereijo, Luis AU - Cereijo L AUID- ORCID: 0000-0003-2118-3806 AD - Public Health and Epidemiology Research Group, School of Medicine and Health Sciences, Universidad de Alcala, 28871 Alcala de Henares, Spain. FAU - Martin-Oliveros, Adela AU - Martin-Oliveros A AD - Sociedad Espanola de Farmacia Clinica, Familiar y Comunitaria (SEFAC), 28045 Madrid, Spain. FAU - Fito, Montse AU - Fito M AD - Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Institute for Medical Research, 08003 Barcelona, Spain. FAU - Berruezo, Paula AU - Berruezo P AUID- ORCID: 0009-0002-6355-6463 AD - Gasol Foundation Europe, 08830 Sant Boi de Llobregat, Spain. AD - Public Health and Epidemiology Research Group, School of Medicine and Health Sciences, Universidad de Alcala, 28871 Alcala de Henares, Spain. FAU - Zapico, Augusto G AU - Zapico AG AUID- ORCID: 0000-0001-6157-4997 AD - ImFINE Research Group, Department of Health and Human Performance, Universidad Politecnica de Madrid, 28040 Madrid, Spain. FAU - Benavente-Marin, Juan Carlos AU - Benavente-Marin JC AUID- ORCID: 0000-0002-4037-0239 AD - EpiPHAAN Research Group, Faculty of Health Sciences, Universidad de Malaga-Instituto de Investigacion Biomedica de Malaga (IBIMA Bionand), 28590 Malaga, Spain. FAU - Sanchez Gomez, Jesus AU - Sanchez Gomez J AD - Physical Activity and Quality of Life Research Group (AFYCAV), Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. AD - Instituto de Investigacion e Innovacion en el Deporte (INIDE), 10003 Caceres, Spain. FAU - Martin-Moraleda, Evelyn AU - Martin-Moraleda E AUID- ORCID: 0000-0002-3769-0522 AD - PAFS Research Group, Faculty of Sports Sciences, University of Castilla-La Mancha-Toledo Campus, 45071 Toledo, Spain. FAU - Alcaraz, Pedro E AU - Alcaraz PE AUID- ORCID: 0000-0002-9792-6656 AD - UCAM Research Center for High Performance Sport, Universidad Catolica de Murcia, 30107 Murcia, Spain. AD - Faculty of Sport, Universidad Catolica de Murcia, 30107 Murcia, Spain. FAU - Sevilla-Sanchez, Marta AU - Sevilla-Sanchez M AUID- ORCID: 0000-0003-2004-9162 AD - Faculty of Sports Sciences and Physical Education, Universidade da Coruna, 15071 A Coruna, Spain. FAU - Herrera-Ramos, Estefania AU - Herrera-Ramos E AUID- ORCID: 0000-0002-5814-3931 AD - Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, 35016 Las Palmas, Spain. FAU - Labayen, Idoia AU - Labayen I AUID- ORCID: 0000-0002-4334-3287 AD - ELIKOS Group, Institute for Sustainability and Food Chain Innovation (IS-FOOD), Department of Health Sciences, Public University of Navarre, 31006 Pamplona, Spain. FAU - Carmona-Rosado, Luis AU - Carmona-Rosado L AD - Public Health and Epidemiology Research Group, School of Medicine and Health Sciences, Universidad de Alcala, 28871 Alcala de Henares, Spain. FAU - Mateos-Lardies, Ana AU - Mateos-Lardies A AUID- ORCID: 0009-0005-8607-0839 AD - Sociedad Espanola de Farmacia Clinica, Familiar y Comunitaria (SEFAC), 28045 Madrid, Spain. FAU - Schroder, Helmut AU - Schroder H AUID- ORCID: 0000-0003-2231-5081 AD - Gasol Foundation Europe, 08830 Sant Boi de Llobregat, Spain. AD - CIBER de Epidemiologia y Salud Publica (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain. AD - Cardiovascular Risk and Nutrition Research Group (CARIN), Hospital del Mar Institute for Medical Research, 08003 Barcelona, Spain. FAU - Bouzas, Cristina AU - Bouzas C AUID- ORCID: 0000-0002-1407-8461 AD - Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain. FAU - Tur, Josep A AU - Tur JA AUID- ORCID: 0000-0002-6940-0761 AD - Research Group on Community Nutrition and Oxidative Stress, University of Balearic Islands-IUNICS, 07122 Palma de Mallorca, Spain. AD - Centro de Investigacion Biomedica en Red Fisiopatologia de la Obesidad y la Nutricion (CIBEROBN), Institute of Health Carlos III, 28029 Madrid, Spain. AD - Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain. LA - eng GR - CIBEROBN CB12/03/30038/Instituto de Salud Carlos III/ GR - CIBERESP CB22/03/00058/Instituto de Salud Carlos III/ GR - N/A/European Regional Development Fund/ GR - N/A/Fundacion PROBITAS/ GR - N/A/Gasol Foundation/ GR - N/A/FC Barcelona Foundation/ GR - N/A/Banco Santander/ GR - N/A/IFA/ GR - N/A/Vienna/ GR - N/A/Fundacion Deporte Joven/ GR - FOLIUM, PRIMUS, SYNERGIA and LIBERI/IDISBA/ GR - Red EXERNET-Red de Ejercicio Fisico y Salud (RED2022-134800-T)/Agencia Estatal de Investigacion (Ministerio de Ciencias e Innovacion, Spain)/ PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260325 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Adolescent MH - Spain/epidemiology MH - Cross-Sectional Studies MH - *Feeding Behavior MH - Nutritional Status MH - *Diet MH - Parents MH - *Diet, Healthy/statistics & numerical data MH - Diet, Mediterranean MH - Child Nutritional Physiological Phenomena MH - Socioeconomic Factors PMC - PMC13074208 OTO - NOTNLM OT - adolescents OT - childhood obesity OT - children OT - parents OT - quality of diet OT - sociodemographic factors COIS- The authors declare no conflicts of interest. EDAT- 2026/04/14 06:32 MHDA- 2026/04/14 06:33 PMCR- 2026/03/25 CRDT- 2026/04/14 01:10 PHST- 2026/02/24 00:00 [received] PHST- 2026/03/18 00:00 [revised] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/04/14 06:33 [medline] PHST- 2026/04/14 06:32 [pubmed] PHST- 2026/04/14 01:10 [entrez] PHST- 2026/03/25 00:00 [pmc-release] AID - nu18071038 [pii] AID - nutrients-18-01038 [pii] AID - 10.3390/nu18071038 [doi] PST - epublish SO - Nutrients. 2026 Mar 25;18(7):1038. doi: 10.3390/nu18071038. PMID- 41978082 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 7 DP - 2026 Mar 24 TI - Randomized Controlled Trial Outcomes for HomeStyles-2, an Online Obesity Prevention Program for Families with Children in Middle Childhood. LID - 10.3390/nu18071029 [doi] LID - 1029 AB - Background: Parents are children's primary role models, are food and physical activity gatekeepers, and create the home structure/lifestyle environment. Thus, parents strongly influence children's weight-related behaviors and have the opportunity to cultivate a "culture of health" within the home. Methods: The aim of the HomeStyles-2 (also called HomeStyles-Child) RCT was to determine whether this online, novel, age-appropriate, family intervention enabled and motivated the 131 systematically randomly assigned by computer parents of children in middle childhood (ages 6 to 11) in the experimental condition to shape home environments and healthy weight-related lifestyle practices to be more supportive of optimal health and reduced obesity risk in middle childhood youth more than the 134 counterparts assigned to the attention control condition. Results: This RCT demonstrated the feasibility of online delivery of a health promotion intervention to parents of children in middle childhood, which may inform the development of interventions targeting other age groups and health outcomes. Results indicate the HomeStyles-Child intervention improved healthy-weight-related behavior cognitions, which are predictors of behavior change, of the experimental group. Additionally, improvements in experimental parent and child health-related behaviors were observed. These improvements occurred during a time when families faced unprecedented and extraordinary economic and social stresses associated with the COVID-19 pandemic. Conclusions: HomeStyles-Child is one of the few interventions for families with middle childhood youth. It has the potential to help ameliorate obesity in middle childhood youth and, by extension, other family members. FAU - Byrd-Bredbenner, Carol AU - Byrd-Bredbenner C AUID- ORCID: 0000-0002-8010-3987 AD - Nutritional Sciences Department, Rutgers University, New Brunswick, NJ 08901, USA. FAU - Pozzoli, Angelica A AU - Pozzoli AA AUID- ORCID: 0000-0002-7875-481X AD - Nutritional Sciences Department, Rutgers University, New Brunswick, NJ 08901, USA. FAU - Eck, Kaitlyn M AU - Eck KM AUID- ORCID: 0000-0002-5724-2524 AD - Department of Nutritional Sciences, Thomas Jefferson University, Philadelphia, PA 19144, USA. FAU - Worobey, John AU - Worobey J AUID- ORCID: 0000-0002-0802-6067 AD - Nutritional Sciences Department, Rutgers University, New Brunswick, NJ 08901, USA. FAU - Shelnutt, Karla Pagan AU - Shelnutt KP AUID- ORCID: 0000-0002-3799-9212 AD - Department of Family, Youth, and Community Sciences, University of Florida, Gainesville, FL 32611, USA. FAU - Olfert, Melissa D AU - Olfert MD AUID- ORCID: 0000-0002-6686-3891 AD - School of Agriculture and Food Systems, West Virginia University, Morgantown, WV 26506, USA. FAU - Quick, Virginia AU - Quick V AUID- ORCID: 0000-0002-4338-963X AD - Nutritional Sciences Department, Rutgers University, New Brunswick, NJ 08901, USA. LA - eng GR - 2017-680001-26351/National Institute of Food and Agriculture/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20260324 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Female MH - *Pediatric Obesity/prevention & control MH - Male MH - *Health Promotion/methods MH - *Parents/psychology MH - Health Behavior MH - *Internet-Based Intervention MH - Home Environment MH - Life Style PMC - PMC13074828 OTO - NOTNLM OT - cognitions OT - health OT - home environment OT - intervention OT - lifestyles OT - middle childhood OT - nutrition OT - obesity OT - parents OT - social cognitive theory COIS- The authors declare no conflicts of interest. The funders had no role in the design of this study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/04/14 06:32 MHDA- 2026/04/14 06:33 PMCR- 2026/03/24 CRDT- 2026/04/14 01:10 PHST- 2026/02/26 00:00 [received] PHST- 2026/03/17 00:00 [revised] PHST- 2026/03/21 00:00 [accepted] PHST- 2026/04/14 06:33 [medline] PHST- 2026/04/14 06:32 [pubmed] PHST- 2026/04/14 01:10 [entrez] PHST- 2026/03/24 00:00 [pmc-release] AID - nu18071029 [pii] AID - nutrients-18-01029 [pii] AID - 10.3390/nu18071029 [doi] PST - epublish SO - Nutrients. 2026 Mar 24;18(7):1029. doi: 10.3390/nu18071029. PMID- 41978080 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 7 DP - 2026 Mar 24 TI - Psychometric Properties and Factor Structure of the Polish ChEDE-Q in a Community Sample of Adolescents: Associations with BMI. LID - 10.3390/nu18071028 [doi] LID - 1028 AB - BACKGROUND: The Child and Adolescent Eating Disorder Examination Questionnaire (ChEDE-Q) is a widely used self-report screening instrument for assessing eating disorder psychopathology in young people. Evidence on the psychometric properties of the Polish-language version remains limited. This pilot study evaluated the internal consistency, dimensional structure, and BMI-related convergent validity of the Polish ChE-DE-Q in a regional youth sample. METHODS: A cross-sectional design was used, including 200 participants aged 10-18 years. Item characteristics and data quality were examined. Internal consistency was assessed using Cronbach's alpha and McDonald's omega. Dimensional structure was evaluated with exploratory factor analysis (EFA) based on a polychoric correlation matrix and confirmatory factor analysis (CFA) comparing one-factor, four-factor, and bifactor models. Convergent validity was examined using Spearman's rank correlations with BMI and linear regression analyses with BMI z-scores. RESULTS: The global score showed high internal consistency (alpha = 0.898; omega = 0.900). Subscale reliability ranged from acceptable to high. EFA supported a multidimensional solution. In CFA, the bifactor model showed the best fit among the tested alternatives (CFI = 0.742; TLI = 0.681; RMSEA = 0.122; SRMR = 0.084), but none of the tested models achieved fully satisfactory absolute fit. The global score correlated positively with BMI (rho = 0.282; p < 0.001) and was significantly associated with BMI z-score in regression analysis (B = 0.334; p < 0.001). CONCLUSIONS: The Polish ChEDE-Q global score demonstrated strong internal consistency and preliminary BMI-related convergent validity. The findings provide initial support for a general factor and for using the global score in screening-oriented research; however, the pilot character of the study and the suboptimal absolute fit indices indicate that further validation in larger and more heterogeneous samples is required. FAU - Wasacz, Malgorzata AU - Wasacz M AD - Department of Medical Communication and Professional Competency Development, Faculty of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland. FAU - Frej, Damian AU - Frej D AUID- ORCID: 0000-0003-1899-4712 AD - Department of Automotive Engineering and Transport, Kielce University of Technology, 25-314 Kielce, Poland. FAU - Ochojska, Danuta AU - Ochojska D AD - Faculty of Health Sciences and Psychology, University of Rzeszow, 35-959 Rzeszow, Poland. FAU - Kopanska, Marta AU - Kopanska M AUID- ORCID: 0000-0003-3936-0698 AD - Department of Medical Communication and Professional Competency Development, Faculty of Medicine, University of Rzeszow, 35-959 Rzeszow, Poland. LA - eng PT - Journal Article DEP - 20260324 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Psychometrics MH - Adolescent MH - Female MH - Child MH - *Body Mass Index MH - Poland MH - Reproducibility of Results MH - Cross-Sectional Studies MH - Male MH - Pilot Projects MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Factor Analysis, Statistical MH - Surveys and Questionnaires PMC - PMC13074324 OTO - NOTNLM OT - BMI OT - ChEDE-Q OT - child eating questionnaire OT - children and adolescents OT - eating disorders OT - psychometric properties COIS- The authors declare that this research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/14 06:32 MHDA- 2026/04/14 06:33 PMCR- 2026/03/24 CRDT- 2026/04/14 01:10 PHST- 2026/02/24 00:00 [received] PHST- 2026/03/19 00:00 [revised] PHST- 2026/03/20 00:00 [accepted] PHST- 2026/04/14 06:33 [medline] PHST- 2026/04/14 06:32 [pubmed] PHST- 2026/04/14 01:10 [entrez] PHST- 2026/03/24 00:00 [pmc-release] AID - nu18071028 [pii] AID - nutrients-18-01028 [pii] AID - 10.3390/nu18071028 [doi] PST - epublish SO - Nutrients. 2026 Mar 24;18(7):1028. doi: 10.3390/nu18071028. PMID- 41978069 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 7 DP - 2026 Mar 24 TI - Weight Perception and Lifestyle Awareness in Children and Adolescents: Insights from a Cross-Sectional Study. LID - 10.3390/nu18071017 [doi] LID - 1017 AB - Background: Misperception of body weight has been found to negatively impact both diet and physical activity levels, particularly in youth with overweight and obesity. Objectives: This study assessed consistency between actual and perceived weight status and lifestyle factors in a sample of 455 children and adolescents (55% males, 8-13 years) attending a summer camp in Northern Italy. Methods: Weight status was defined applying Body Mass Index (BMI) cut-offs. Adherence to the Mediterranean Diet (MD), physical activity level, sleep duration, and sleep quality were assessed through validated questionnaires. Self-perception was evaluated through 5-point Likert scales, with graphical representations. Results: Comparison between self-perceived and assessed parameters revealed a poor concordance across all types of variables. Approximately half of participants (43-55%) correctly rated their weight status (kappa = 0.12; 95% CI: 0.05-0.19), diet quality (kappa = 0.09; 95% CI: 0.02-0.15), physical activity level (kappa = 0.18; 95% CI: 0.11-0.26), sleep time (kappa = 0.10; 95% CI: 0.03-0.17), and sleep quality (kappa = 0.18; 95% CI: 0.12-0.24). Participants 12-13 years old were more likely to have a greater weight status perception compared to younger subjects (OR = 2.13; 95% CI: 1.08-4.21). Being in a condition of overweight or obesity significantly decreased the odds of correct weight perception (OR = 0.13; 95% CI: 0.08-0.21). Similarly, subjects with higher adherence to the MD, adequate sleep time, and low sleep quality were more conscious about their diet and sleep patterns. Conclusions: Overall, these findings highlight a certain degree of misclassification, especially in subjects who need to improve their lifestyles, highlighting the potential relevance of fostering accurate self-perception during developmental age. FAU - Franchini, Cinzia AU - Franchini C AUID- ORCID: 0000-0003-4886-7431 AD - Human Nutrition Unit, Department of Food and Drug, University of Parma, 39 Via Volturno, 43125 Parma, Italy. FAU - Bertolotti, Elena AU - Bertolotti E AD - Human Nutrition Unit, Department of Food and Drug, University of Parma, 39 Via Volturno, 43125 Parma, Italy. FAU - Biasini, Beatrice AU - Biasini B AUID- ORCID: 0000-0002-2928-0961 AD - Human Nutrition Unit, Department of Food and Drug, University of Parma, 39 Via Volturno, 43125 Parma, Italy. FAU - De Panfilis, Chiara AU - De Panfilis C AD - Unit of Neuroscience, Department of Medicine and Surgery, University of Parma, 43126 Parma, Italy. FAU - Esposito, Susanna AU - Esposito S AUID- ORCID: 0000-0003-4103-2837 AD - Pediatric Clinic, Parma University Hospital, Department of Medicine and Surgery, University of Parma, Viale Gramsci 14, 43126 Parma, Italy. FAU - Rosi, Alice AU - Rosi A AUID- ORCID: 0000-0001-8533-797X AD - Human Nutrition Unit, Department of Food and Drug, University of Parma, 39 Via Volturno, 43125 Parma, Italy. FAU - Scazzina, Francesca AU - Scazzina F AUID- ORCID: 0000-0002-5372-8658 AD - Human Nutrition Unit, Department of Food and Drug, University of Parma, 39 Via Volturno, 43125 Parma, Italy. AD - Giocampus Scientific Committee, 38 Parco Area delle Scienze, 43124 Parma, Italy. LA - eng PT - Journal Article DEP - 20260324 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Male MH - Child MH - Cross-Sectional Studies MH - Female MH - *Life Style MH - Exercise MH - *Body Weight MH - Body Mass Index MH - *Self Concept MH - Sleep Duration MH - *Body Image/psychology MH - Surveys and Questionnaires MH - Diet, Mediterranean MH - Italy MH - Sleep MH - Overweight/psychology MH - *Health Knowledge, Attitudes, Practice MH - Sleep Quality PMC - PMC13074309 OTO - NOTNLM OT - BMI OT - KIDMED OT - body image OT - camps OT - food habits OT - lifestyle OT - physical activity OT - self-perception OT - sleep quality COIS- The authors declare no conflicts of interest. EDAT- 2026/04/14 06:31 MHDA- 2026/04/14 06:32 PMCR- 2026/03/24 CRDT- 2026/04/14 01:10 PHST- 2026/02/06 00:00 [received] PHST- 2026/03/17 00:00 [revised] PHST- 2026/03/20 00:00 [accepted] PHST- 2026/04/14 06:32 [medline] PHST- 2026/04/14 06:31 [pubmed] PHST- 2026/04/14 01:10 [entrez] PHST- 2026/03/24 00:00 [pmc-release] AID - nu18071017 [pii] AID - nutrients-18-01017 [pii] AID - 10.3390/nu18071017 [doi] PST - epublish SO - Nutrients. 2026 Mar 24;18(7):1017. doi: 10.3390/nu18071017. PMID- 41976791 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260414 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 7 DP - 2026 Mar 24 TI - Prediction of In-Hospital Respiratory Support Among Children Aged 2-59 Months Hospitalized with Pneumonia in Southern Vietnam: A Retrospective Cohort Study. LID - 10.3390/jcm15072490 [doi] LID - 2490 AB - Respiratory support requirement among children hospitalized with pneumonia is a key marker of disease severity and resource needs, yet scalable risk stratification tools for routine hospital settings in Southern Vietnam remain limited. Background: This study aimed to develop and evaluate clinical and laboratory-based multivariable models to predict respiratory support requirement in children under five hospitalized with pneumonia, using a routine care dataset. Methods: We conducted a retrospective cohort study conducted at a tertiary pediatric hospital in Southern Vietnam (July 2024-November 2025), children aged 2-59 months hospitalized with pneumonia were included after predefined exclusions. The outcome was the maximum (worst) level of respiratory support required during hospitalization (oxygen therapy, CPAP, or invasive mechanical ventilation), analyzed as a binary endpoint (any support vs. none) for model development. Candidate predictors included bedside clinical variables (age < 12 months, malnutrition, recurrent pneumonia, cyanosis, tachypnea, chest indrawing) and complete blood count-derived inflammatory indices. Univariable logistic regression was used for crude associations. Two multivariable logistic regression models were built: Model 1 (clinical-only) and Model 2 (clinical + neutrophil-to-lymphocyte ratio [NLR]; primary). Discrimination was assessed using area under the ROC curve (AUC), and calibration was evaluated using the Hosmer-Lemeshow test and observed-to-expected (O:E) ratio. Results: A total of 1797 children were included; 154 (8.6%) required respiratory support. In the primary model, independent predictors were age < 12 months (aOR 2.57, 95% CI 1.69-3.92), malnutrition (aOR 4.33, 2.56-7.33), recurrent pneumonia (aOR 1.82, 1.18-2.81), cyanosis (aOR 24.02, 7.41-77.87), chest indrawing (aOR 4.19, 2.73-6.43), and higher NLR (per 1 unit: aOR 1.49, 1.38-1.60), while tachypnea was not independently associated after adjustment. Discrimination improved from Model 1 (AUC 0.754) to Model 2 (AUC 0.840; 95% CI 0.806-0.874). At the optimal probability cut-off (0.122), Model 2 achieved sensitivity 66.2%, specificity 86.2%, PPV 31.1%, NPV 96.5%, and accuracy 84.5%. Calibration was acceptable (Hosmer-Lemeshow p = 0.662; O:E = 1.00). Conclusions: A simple clinical model strengthened by NLR provided good discrimination and calibration for predicting respiratory support requirement among children under-five hospitalized with pneumonia in Southern Vietnam. This approach may support early triage, prioritization of monitoring intensity, and escalation readiness in resource-constrained settings, although external validation is warranted. FAU - Vo, Thi Van AU - Vo TV AUID- ORCID: 0009-0008-8377-0217 AD - Department of Pediatrics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, No. 179 Nguyen Van Cu Street, Tan An Ward, Can Tho 900000, Vietnam. FAU - Nguyen, Phuong Minh AU - Nguyen PM AUID- ORCID: 0000-0002-3857-9420 AD - Department of Pediatrics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, No. 179 Nguyen Van Cu Street, Tan An Ward, Can Tho 900000, Vietnam. FAU - Lu, Dien Tri AU - Lu DT AUID- ORCID: 0009-0009-8025-3692 AD - Internal Medicine Program, Department of General Nursing, Faculty of Nursing and Medical Technology, Can Tho University of Medicine and Pharmacy, No. 179 Nguyen Van Cu Street, Tan An Ward, Can Tho 900000, Vietnam. FAU - Ong, Thanh Huy AU - Ong TH AUID- ORCID: 0009-0006-2815-2278 AD - Can Tho Children's Hospital, No. 345 Nguyen Van Cu Street, An Binh Ward, Can Tho 900000, Vietnam. FAU - Nguyen, Tri Duc AU - Nguyen TD AUID- ORCID: 0009-0003-9356-6846 AD - Can Tho Children's Hospital, No. 345 Nguyen Van Cu Street, An Binh Ward, Can Tho 900000, Vietnam. FAU - Thai, Dien Minh AU - Thai DM AUID- ORCID: 0009-0000-7007-8485 AD - Faculty of Medicine, Nam Can Tho University, No. 168 Nguyen Van Cu Street, An Binh Ward, Can Tho 900000, Vietnam. FAU - Tran, Duc Hoang Minh AU - Tran DHM AUID- ORCID: 0009-0006-0400-8773 AD - Department of Pediatrics, Faculty of Medicine, Can Tho University of Medicine and Pharmacy, No. 179 Nguyen Van Cu Street, Tan An Ward, Can Tho 900000, Vietnam. LA - eng PT - Journal Article DEP - 20260324 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13073457 OTO - NOTNLM OT - Vietnam OT - child OT - logistic regression OT - neutrophil-to-lymphocyte ratio OT - pneumonia OT - respiratory support OT - risk prediction COIS- The authors declare no conflict of interest. EDAT- 2026/04/14 06:31 MHDA- 2026/04/14 06:32 PMCR- 2026/03/24 CRDT- 2026/04/14 01:06 PHST- 2026/01/23 00:00 [received] PHST- 2026/03/10 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/04/14 06:32 [medline] PHST- 2026/04/14 06:31 [pubmed] PHST- 2026/04/14 01:06 [entrez] PHST- 2026/03/24 00:00 [pmc-release] AID - jcm15072490 [pii] AID - jcm-15-02490 [pii] AID - 10.3390/jcm15072490 [doi] PST - epublish SO - J Clin Med. 2026 Mar 24;15(7):2490. doi: 10.3390/jcm15072490. PMID- 41975844 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260414 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 7 DP - 2026 Mar 25 TI - Attitudes Towards Sport in Early Adolescence: A Scale Adaptation Study for Sustainable Good Health and Well-Being. LID - 10.3390/healthcare14070842 [doi] LID - 842 AB - BACKGROUND: The decline in physical activity during the transition to early adolescence poses a significant threat to lifelong health and well-being, directly impacting the targets of Sustainable Development Goal 3 (SDG 3). To design effective preventive interventions, researchers need developmentally appropriate tools to measure the psychological drivers of physical activity. OBJECTIVES: This study aimed to adapt the Attitude Towards Sport Scale (ATSS) for middle school students (ages 10-15) and evaluate its psychometric properties. METHODS: We used a mixed-methods approach comprising a qualitative cognitive think-aloud phase (n = 27) and a quantitative cross-sectional validation phase (N = 531). Data were analyzed using robust Confirmatory Factor Analysis (CFA). RESULTS: The results supported the structural model, demonstrating that the original three-factor structure fits the early adolescent sample acceptably. The scale demonstrated high composite reliability across all dimensions. Furthermore, the adapted ATSS-EA showed strong criterion-related validity through high correlations with perceived physical literacy and actual physical activity durations. It also successfully differentiated between licensed athletes and non-licensed students. CONCLUSIONS: The adapted ATSS-EA provides a developmentally appropriate tool for educators and researchers to monitor sport attitudes and identify students at risk of physical disengagement. FAU - Senturk, Halil Evren AU - Senturk HE AUID- ORCID: 0000-0001-7402-0758 AD - Faculty of Sport Sciences, Mugla Sitki Kocman University, Mugla 48000, Turkiye. FAU - Tanir, Gulsum AU - Tanir G AD - Institute of Health Sciences, Mugla Sitki Kocman University, Mugla 48000, Turkiye. FAU - Erdogan Yuce, Ulkum AU - Erdogan Yuce U AD - Ministry of National Education, Mugla 48700, Turkiye. FAU - Karatut, Adem AU - Karatut A AUID- ORCID: 0000-0003-1927-5656 AD - Ministry of National Education, Kocaeli 41050, Turkiye. FAU - Karakas, Ecesu AU - Karakas E AD - Faculty of Sport Sciences, Mugla Sitki Kocman University, Mugla 48000, Turkiye. LA - eng PT - Journal Article DEP - 20260325 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13073176 OTO - NOTNLM OT - early adolescence OT - good health OT - health-lifestyle behaviors OT - physical activity OT - physical literacy OT - preventive healthcare OT - psychometrics OT - scale adaptation OT - sports attitude OT - well-being COIS- The authors declare no conflicts of interest. EDAT- 2026/04/14 06:31 MHDA- 2026/04/14 06:32 PMCR- 2026/03/25 CRDT- 2026/04/14 01:02 PHST- 2026/03/07 00:00 [received] PHST- 2026/03/20 00:00 [revised] PHST- 2026/03/20 00:00 [accepted] PHST- 2026/04/14 06:32 [medline] PHST- 2026/04/14 06:31 [pubmed] PHST- 2026/04/14 01:02 [entrez] PHST- 2026/03/25 00:00 [pmc-release] AID - healthcare14070842 [pii] AID - healthcare-14-00842 [pii] AID - 10.3390/healthcare14070842 [doi] PST - epublish SO - Healthcare (Basel). 2026 Mar 25;14(7):842. doi: 10.3390/healthcare14070842. PMID- 41975386 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Apr 13 TI - The association of the ALBI score with disease severity and perinatal outcomes in the preeclampsia spectrum. LID - 10.1186/s12884-026-09049-6 [doi] LID - 553 AB - BACKGROUND: This study aimed to investigate the association between the albumin-bilirubin (ALBI) score and disease severity across the preeclampsia spectrum and to evaluate its relationship with perinatal outcomes, with particular emphasis on differences according to gestational age. METHODS: In this retrospective cross-sectional study, medical records of 370 pregnant women diagnosed with preeclampsia between June 2021 and June 2025 were analyzed. Patients were stratified by gestational age at delivery (< 34 weeks and >/= 34 weeks) and by disease severity (mild-to-moderate preeclampsia vs. severe preeclampsia). Maternal biochemical, hematological, and inflammatory parameters were recorded, and the ALBI score was calculated using serum albumin and total bilirubin levels. Perinatal outcomes included birth weight, Apgar scores, umbilical cord blood gas parameters, admission to the Neonatal Intensive Care Unit (NICU), and length of NICU stay. Receiver operating characteristic analyses were performed to assess the discriminative performance of the ALBI score. RESULTS: The ALBI score was significantly higher in severe preeclampsia regardless of gestational age and showed superior discriminative performance compared with inflammatory indices, particularly in early-onset disease (< 34 weeks; AUC = 0.702). Higher ALBI scores were associated with adverse perinatal outcomes, including lower birth weight and increased NICU admission. In contrast, inflammatory indices (NLR, PLR, LMR, and SII) did not demonstrate clinically meaningful discrimination of disease severity or neonatal risk. Gestational age at delivery was the primary determinant of NICU length of stay. CONCLUSIONS: The ALBI score is a robust, low-cost, and easily applicable biomarker that reflects biochemical disease severity and perinatal risk across the preeclampsia spectrum, particularly in early-onset severe preeclampsia. Prospective multicenter studies are required to confirm its clinical utility and define its role in future risk stratification algorithms. FAU - Akcabay, Cigdem AU - Akcabay C AUID- ORCID: 0000-0003-2068-7412 AD - Department of Obstetrics and Gynecology, Firat University Faculty of Medicine, Elazig, Turkey. FAU - Onat, Miray AU - Onat M AUID- ORCID: 0009-0008-8085-3703 AD - Fethi Sekin City Hospital, Gynecology and Obstetrics Clinic, Elazig, Turkey. FAU - Aslan, Neslihan AU - Aslan N AUID- ORCID: 0009-0005-0437-1700 AD - Fethi Sekin City Hospital, Gynecology and Obstetrics Clinic, Elazig, Turkey. FAU - Kavak, Ebru Celik AU - Kavak EC AUID- ORCID: 0000-0002-7447-8264 AD - Gynecology and Obstetrics Specialist, Elazig, Turkey. FAU - Sanli, Cengiz AU - Sanli C AUID- ORCID: 0000-0002-8782-5202 AD - Fethi Sekin City Hospital, Gynecology and Obstetrics Clinic, Elazig, Turkey. FAU - Batmaz, Ibrahim AU - Batmaz I AUID- ORCID: 0000-0001-9492-2783 AD - Department of Obstetrics and Gynecology, Faculty of Medicine, Mardin Artuklu University, Mardin, Turkey. FAU - Kavak, Salih Burcin AU - Kavak SB AUID- ORCID: 0000-0002-6318-5175 AD - Department of Obstetrics and Gynecology, Firat University Faculty of Medicine, Elazig, Turkey. burcinkavak1@gmail.com. LA - eng PT - Journal Article DEP - 20260413 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - RFM9X3LJ49 (Bilirubin) RN - 0 (Serum Albumin) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Pre-Eclampsia/blood/diagnosis MH - Pregnancy MH - Cross-Sectional Studies MH - *Severity of Illness Index MH - Retrospective Studies MH - Adult MH - Gestational Age MH - *Bilirubin/blood MH - Pregnancy Outcome MH - Infant, Newborn MH - *Serum Albumin/analysis MH - Biomarkers/blood MH - Birth Weight MH - Intensive Care Units, Neonatal/statistics & numerical data MH - ROC Curve MH - Apgar Score MH - Length of Stay/statistics & numerical data PMC - PMC13188733 OTO - NOTNLM OT - ALBI score OT - Disease severity OT - Gestational age OT - Perinatal outcomes OT - Preeclampsia COIS- Declarations. Ethics approval and consent to participate: The study received ethical approval from the Firat University Faculty of Medicine Local Ethics Committee (Ethics Committee Decision No: 2025/13-26; Session Date: 14.09.2025; Clinical trial number: not applicable.). All methods were performed in accordance with the relevant guidelines and regulations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/14 00:32 MHDA- 2026/06/27 18:37 PMCR- 2026/04/13 CRDT- 2026/04/14 00:00 PHST- 2025/12/19 00:00 [received] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/06/27 18:37 [medline] PHST- 2026/04/14 00:32 [pubmed] PHST- 2026/04/14 00:00 [entrez] PHST- 2026/04/13 00:00 [pmc-release] AID - 10.1186/s12884-026-09049-6 [pii] AID - 9049 [pii] AID - 10.1186/s12884-026-09049-6 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Apr 13;26(1):553. doi: 10.1186/s12884-026-09049-6. PMID- 41975246 OWN - NLM STAT- Publisher LR - 20260413 IS - 1552-5732 (Electronic) IS - 0890-3344 (Linking) DP - 2026 Apr 13 TI - Development and Psychometric Properties of the Breastfeeding Behaviour in Public Scale. PG - 8903344261432407 LID - 10.1177/08903344261432407 [doi] AB - BACKGROUND: Breastfeeding is universally recognised as the best nutrition for infants, yet women's public breastfeeding experiences are shaped by cultural norms, privacy concerns, and social judgments, and no valid scale currently exists to measure these behaviours. RESEARCH AIM: The aim of this study is to develop a valid and reliable instrument to measure mothers' behaviours towards breastfeeding in public. METHODS: This methodological study included 390 mothers with breastfeeding experience. The final version of the scale subjected to analysis consisted of 17 items. The scale's construct validity was evaluated using Exploratory Factor Analysis, item validity was assessed by comparing the mean scores of the upper and lower 27% groups, and model fit was tested through Confirmatory Factor Analysis. The reliability of the scale was analysed using Cronbach's alpha reliability coefficient, item-total correlation, and split-half reliability. RESULTS: The scale demonstrated a four-factor structure, with good model fit indices (RMSEA = 0.064; GFI = 0.91; CFI = 0.94) and a Cronbach's alpha coefficient of 0.89. CONCLUSION: The study demonstrated that the Breastfeeding Behaviour in Public Scale is a valid and reliable instrument for evaluating mothers' behaviours towards breastfeeding in public. FAU - Dundar, Tugba AU - Dundar T AUID- ORCID: 0000-0002-6693-0820 AD - Aydin Adnan Menderes University, Turkiye. FAU - Ozsoy, Sevgi AU - Ozsoy S AUID- ORCID: 0000-0002-8851-8140 AD - Aydin Adnan Menderes University, Turkiye. FAU - Ates, Gulsah AU - Ates G AD - Aydin Maternity and Child Diseases Hospital, Lactation Consultant, Turkiye. LA - eng PT - Journal Article DEP - 20260413 PL - United States TA - J Hum Lact JT - Journal of human lactation : official journal of International Lactation Consultant Association JID - 8709498 SB - IM OTO - NOTNLM OT - breastfeeding OT - methodological study OT - nurse OT - public area OT - scale EDAT- 2026/04/14 00:32 MHDA- 2026/04/14 00:32 CRDT- 2026/04/13 23:42 PHST- 2026/04/14 00:32 [medline] PHST- 2026/04/14 00:32 [pubmed] PHST- 2026/04/13 23:42 [entrez] AID - 10.1177/08903344261432407 [doi] PST - aheadofprint SO - J Hum Lact. 2026 Apr 13:8903344261432407. doi: 10.1177/08903344261432407. PMID- 41975244 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260925 IS - 1552-5732 (Electronic) IS - 0890-3344 (Linking) VI - 42 IP - 3 DP - 2026 Aug TI - The Feasibility of Donor Human Milk Banking in Turkiye: A Qualitative Analysis of Religious, Institutional, and Policy Dynamics. PG - 842-849 LID - 10.1177/08903344261431952 [doi] AB - Research Aim(s)/Question(s):The study aims to ascertain the views of relevant stakeholders regarding the facilitators and barriers to establishing human milk banks in Turkiye and to identify policy requirements for social acceptance. METHODS: A qualitative approach was employed, using in-depth interviews with 22 experts in maternal and child health, including physicians, midwives, nurses, and health managers. Data were analyzed using Braun and Clarke's six-phase thematic analysis framework. RESULTS: Four central themes and twelve categories emerged: (1) the multifaceted value of human milk, (2) perceptions toward human milk donation, (3) social and institutional barriers, and (4) perspectives on current human milk feeding policies. Key findings highlight that while the biological importance of milk is universally recognized, donation is hindered by "milk kinship" concerns and legal ambiguities. However, the integration of donation data into the national e-Nabiz electronic health record system and alignment with religious foundations (e.g., Surah Al-Baqarah, Verse 233) were identified as critical policy facilitators. CONCLUSION: Stakeholders emphasize that human milk banking is a viable model for Turkiye if implemented through a framework that resolves legal-religious contradictions. Success depends on extending maternity leaves to support breastfeeding rights and establishing a formal dialogue with religious authorities. These findings provide a strategic roadmap for policymakers to integrate human milk banking into public health policy as a sustainable and socially acceptable service. FAU - Kartal, Nazan AU - Kartal N AUID- ORCID: 0000-0002-5416-7952 AD - Health Management, Faculty of Health Sciences, Cankiri Karatekin University, Cankiri, Turkiye. FAU - Arikan, Gamze AU - Arikan G AD - Mersin University, Faculty of Health Sciences, Department of Health Management, Mersin, Turkiye. FAU - Yildirim, Ebru AU - Yildirim E AD - Cankiri Karatekin University, Faculty of Health Sciences, Midwifery Department Cankiri, Turkiye. LA - eng PT - Journal Article DEP - 20260413 PL - United States TA - J Hum Lact JT - Journal of human lactation : official journal of International Lactation Consultant Association JID - 8709498 SB - IM MH - Humans MH - *Milk Banks/organization & administration/standards MH - Qualitative Research MH - Female MH - *Milk, Human MH - *Tissue Donors MH - Health Policy MH - Feasibility Studies MH - Breast Feeding MH - Religion OTO - NOTNLM OT - Breastfeeding OT - Turkiye OT - human milk banking OT - milk kinship OT - qualitative research COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/04/14 00:30 MHDA- 2026/09/25 11:44 CRDT- 2026/04/13 23:42 PHST- 2026/09/25 11:44 [medline] PHST- 2026/04/14 00:30 [pubmed] PHST- 2026/04/13 23:42 [entrez] AID - 10.1177/08903344261431952 [doi] PST - ppublish SO - J Hum Lact. 2026 Aug;42(3):842-849. doi: 10.1177/08903344261431952. Epub 2026 Apr 13. PMID- 41975139 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260921 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 5 DP - 2026 Apr 14 TI - Hypoxic-ischemic enterocolitis in extremely low birth weight infants: diagnostic insights from a pilot study. LID - 10.1007/s00431-026-06852-3 [doi] LID - 261 AB - Hypoxic-ischemic enterocolitis (HIEnt) in extremely low birth weight (ELBW) infants represents a significant clinical challenge, frequently occurring in the first week and remaining undetected because of its non-specific presentation. Timely and accurate diagnosis is crucial for improving the poor outcomes associated with this condition. The aim of this pilot study was to evaluate early diagnostic tools and characterize HIEnt in a cohort of ELBW infants during the first week of life, with the goal of identifying promising markers for future large-scale studies. In this prospective, single-center pilot study, 23 ELBW infants (< 1000 g) born from July 2023 to February 2024 were enrolled. Clinical, perinatal, and neonatal variables, along with serum biomarkers (sodium, platelets, bicarbonate, and intestinal fatty acid-binding protein [I-FABP]), were systematically collected on days 2, 4, and 6. HIEnt was diagnosed according to modified Bell's criteria. Three infants (13%) were diagnosed with HIEnt. HIEnt cases exhibited significantly lower birth weight (mean 568.33 g vs. 818.00 g; p = 0.03) and a higher incidence of abnormal antenatal Doppler findings (100% vs. 20%; p = 0.02) compared to non-HIEnt infants. Platelet counts were lower in the HIEnt group on day 4 (p = 0.06), and initiation of diet was significantly delayed (mean 14.5 days vs. 3.59 days; p = 0.04). Serum I-FABP levels did not demonstrate significant differences or consistent temporal trends, and common clinical symptoms did not distinguish between groups. CONCLUSION: Prenatal risk factors, low birth weight, feeding intolerance, and decreased platelet levels may serve as early indicators of HIEnt in ELBW infants, underscoring the condition's distinct pathophysiological origins. These findings underscore the need for integrated, multimodal diagnostic strategies and support the pursuit of larger, multicenter validation studies to improve the detection of HIEnt and outcomes in this vulnerable population. WHAT IS KNOWN: * Hypoxic-Ischemic Enterocolitis (HIEnt) in extremely low birth weight (ELBW) infants is a distinct and severe condition manifesting within the first week of life. It is frequently underdiagnosed due to non-specific clinical signs and the limited sensitivity of existing diagnostic tools. WHAT IS KNOWN: * This pilot study identifies significant predictors and diagnostic tools, including lower birth weight, abnormal antenatal Doppler findings, early platelet decline, and feeding intolerance, as potential early indicators of HIEnt in ELBW infants during the first week of life, underscoring the need for multimodal diagnostic strategies. CI - (c) 2026. The Author(s). FAU - Ferrari, Taina Cristina AU - Ferrari TC AD - Department of Pediatrics, Ribeirao, Preto Medical School, University of Sao Paulo, Bandeirantes Avenue 3900, Ribeirao Preto, Sao Paulo, Brazil. FAU - Saia, Rafael Simone AU - Saia RS AD - Department of Physiology, Ribeirao, Preto Medical School, University of Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil. FAU - Ferreira, Cristina Helena Faleiros AU - Ferreira CHF AD - Department of Pediatrics, Ribeirao, Preto Medical School, University of Sao Paulo, Bandeirantes Avenue 3900, Ribeirao Preto, Sao Paulo, Brazil. FAU - Barszcz, Karin AU - Barszcz K AD - Department of Pediatrics, Ribeirao, Preto Medical School, University of Sao Paulo, Bandeirantes Avenue 3900, Ribeirao Preto, Sao Paulo, Brazil. FAU - Goncalves-Ferri, Walusa Assad AU - Goncalves-Ferri WA AD - Department of Pediatrics, Ribeirao, Preto Medical School, University of Sao Paulo, Bandeirantes Avenue 3900, Ribeirao Preto, Sao Paulo, Brazil. walusa@fmrp.usp.br. LA - eng PT - Journal Article DEP - 20260414 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Pilot Projects MH - *Infant, Extremely Low Birth Weight MH - Infant, Newborn MH - Female MH - Prospective Studies MH - Biomarkers/blood MH - Male MH - *Enterocolitis, Necrotizing/diagnosis MH - *Infant, Premature, Diseases/diagnosis MH - Early Diagnosis PMC - PMC13076400 OTO - NOTNLM OT - Extremely low birth weight OT - Hypoxic-ischemic enterocolitis OT - Necrotizing enterocolitis OT - Preterm infant EDAT- 2026/04/14 00:32 MHDA- 2026/04/14 00:33 PMCR- 2026/04/14 CRDT- 2026/04/13 23:34 PHST- 2026/01/04 00:00 [received] PHST- 2026/03/07 00:00 [accepted] PHST- 2026/02/25 00:00 [revised] PHST- 2026/04/14 00:33 [medline] PHST- 2026/04/14 00:32 [pubmed] PHST- 2026/04/13 23:34 [entrez] PHST- 2026/04/14 00:00 [pmc-release] AID - 10.1007/s00431-026-06852-3 [pii] AID - 6852 [pii] AID - 10.1007/s00431-026-06852-3 [doi] PST - epublish SO - Eur J Pediatr. 2026 Apr 14;185(5):261. doi: 10.1007/s00431-026-06852-3. PMID- 41974915 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Apr 13 TI - The chain mediating effects of psychological resilience and social adaptability on the relationship between physical activity and mental health in Chinese university students. LID - 10.1038/s41598-026-48168-0 [doi] LID - 17197 AB - Mental health issues among university students have attracted increasing attention, underscoring the need to identify modifiable protective factors. This cross-sectional study examined the association between physical activity (PA) and mental health (MH) among Chinese university students, with a focus on the mediating roles of psychological resilience (PR) and social adaptability (SA). A sample of 519 students from three universities in the Beijing-Tianjin-Hebei region completed validated questionnaires assessing PA (Physical Activity Rating Scale-3), MH (12-item General Health Questionnaire), PR (Adolescent Psychological Resilience Scale), and SA (Social Adaptability Scale). Pearson correlation analysis and structural equation modeling with Bootstrap methods were employed to test direct and indirect effects. Results revealed that PA was positively correlated with PR, SA, and MH. PR and SA independently mediated the PA-MH relationship, and a significant sequential mediation pathway (PA --> PR --> SA --> MH) was observed, indicating that PA was associated with better MH through the chain effects of PR and SA. These findings suggest that the MH benefits of PA may operate not only directly but also through an association with enhanced internal psychological resources and external SA. University health programs that integrate PA with resilience and social-skills interventions may help improve student MH. CI - (c) 2026. The Author(s). FAU - Liu, Wanxu AU - Liu W AD - School of the Arts, Beijing Sport University, 48 Xinxi Road, Haidian District, Beijing, 100084, China. FAU - Wang, Zilin AU - Wang Z AD - School of Sport Science, Beijing Sport University, 48 Xinxi Road, Haidian District, Beijing, 100084, China. FAU - Hou, Xinyi AU - Hou X AD - School of the Arts, Beijing Sport University, 48 Xinxi Road, Haidian District, Beijing, 100084, China. FAU - Sun, Yuanxin AU - Sun Y AD - School of the Arts, Beijing Sport University, 48 Xinxi Road, Haidian District, Beijing, 100084, China. FAU - Xu, Ke AU - Xu K AD - School of the Arts, Beijing Sport University, 48 Xinxi Road, Haidian District, Beijing, 100084, China. 13810933757@163.com. LA - eng GR - No. 2106056/The 2024 Beijing Sport University Research Project on Ideological and Political Work for College Students/ PT - Journal Article DEP - 20260413 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Students/psychology MH - *Mental Health MH - *Resilience, Psychological MH - Female MH - Universities MH - *Exercise/psychology MH - Male MH - Young Adult MH - China MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - *Social Adjustment MH - Adolescent MH - Adult PMC - PMC13234124 OTO - NOTNLM OT - Chinese University Students OT - Mediation OT - Mental Health OT - Physical Activity OT - Psychological Resilience OT - Social Adaptability COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/04/14 00:31 MHDA- 2026/06/11 06:40 PMCR- 2026/04/13 CRDT- 2026/04/13 23:27 PHST- 2026/01/26 00:00 [received] PHST- 2026/04/06 00:00 [accepted] PHST- 2026/06/11 06:40 [medline] PHST- 2026/04/14 00:31 [pubmed] PHST- 2026/04/13 23:27 [entrez] PHST- 2026/04/13 00:00 [pmc-release] AID - 10.1038/s41598-026-48168-0 [pii] AID - 48168 [pii] AID - 10.1038/s41598-026-48168-0 [doi] PST - epublish SO - Sci Rep. 2026 Apr 13;16(1):17197. doi: 10.1038/s41598-026-48168-0. PMID- 41974697 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 2041-1723 (Electronic) IS - 2041-1723 (Linking) VI - 17 IP - 1 DP - 2026 Apr 13 TI - Multiomics characterization of acute child illness and mortality in Africa and South Asia. LID - 10.1038/s41467-026-69754-w [doi] LID - 5171 AB - Childhood illnesses from infectious diseases in low- and middle-income countries contribute substantially to the global under-five mortality. Many hospitalized children experience incomplete recovery, readmission, and post-discharge mortality despite guideline-directed care. However, targeted interventions remain elusive due to limited understanding of underlying mechanisms. In this work, we employ multiomic profiling and multivariate modeling to investigate biological drivers of inpatient and post-discharge mortality in 3,101 acutely ill children across nine sites in sub-Saharan Africa and South Asia. In a nested case-cohort (N = 1008), we generate plasma proteomics, serum metabolomics and lipidomics, stool metagenomics, and fecal pathogen data at admission and discharge. Additionally, we profile 270 geographically matched community children for biological baselines. We identify a generalizable mortality signature marked by immune, inflammatory, and metabolic dysregulation with gut dysbiosis. We show that mortality-associated signals persist from admission through discharge, indicating unresolved disease and that malnourished children show greater baseline perturbations, explaining elevated risk. We also find some children with low clinical severity display high predicted mortality risk from targeted biomarkers. Finally, we distill predictive models to a clinically feasible biomarker panel and validate our findings in an independent cohort (N = 100). By linking inpatient and post-discharge mortality to specific biological mechanisms, our findings highlight why current care can fail and demonstrate how biomarker-guided risk stratification can identify vulnerable children currently missed by clinical assessments, enabling targeted interventions to reduce mortality in low- and middle-income countries. CI - (c) 2026. The Author(s). FAU - Espinosa, Camilo A AU - Espinosa CA AUID- ORCID: 0000-0003-1630-1564 AD - Department of Anesthesiology, Perioperative and Pain Medicine, StanfordStanford University School of Medicine, Stanford, CA, USA. AD - Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. AD - Department of Biomedical Informatics, Stanford University School of Medicine, Stanford, CA, USA. FAU - Njunge, James M AU - Njunge JM AUID- ORCID: 0000-0002-8524-9133 AD - The Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. AD - KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. FAU - Tickell, Kirkby D AU - Tickell KD AD - Global Health and Epidemiology, University of Washington, Seattle, WA, USA. FAU - Diallo, Abdoulaye Hama AU - Diallo AH AD - Department of Public Health, Faculty of Health Sciences, University of Ouagadougou, Ouagadougou, Burkina Faso. FAU - Sayeem Bin Shahid, Abu Sadat Mohammad AU - Sayeem Bin Shahid ASM AD - Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddrb), Dhaka, Bangladesh. FAU - Gazi, Md Amran AU - Gazi MA AD - Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddrb), Dhaka, Bangladesh. FAU - Kazi, Zaubina AU - Kazi Z AD - Department of Pediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan. FAU - Yoshioka, Emily AU - Yoshioka E AD - Global Health and Epidemiology, University of Washington, Seattle, WA, USA. FAU - Tigoi, Caroline AU - Tigoi C AD - The Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. AD - KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. FAU - Mburu, Moses AU - Mburu M AD - The Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. AD - KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. FAU - Ngari, Moses AU - Ngari M AUID- ORCID: 0000-0001-7149-5491 AD - The Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. AD - KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. FAU - Ngao, Narshion AU - Ngao N AD - The Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. AD - KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. FAU - Omer, Elisha AU - Omer E AD - The Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. AD - KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. FAU - Gumbi, Wilson AU - Gumbi W AD - The Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. AD - KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. FAU - Gichuki, Bonface M AU - Gichuki BM AUID- ORCID: 0000-0001-8766-7470 AD - The Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. AD - KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. AD - Wellcome Sanger Institute, Hinxton, UK. FAU - Mitchel, Anna AU - Mitchel A AD - Standard BioTools, Inc., Standard BioTools, Inc., Boulder, CO, USA. FAU - Williams, Jessica AU - Williams J AD - Standard BioTools, Inc., Standard BioTools, Inc., Boulder, CO, USA. FAU - Gogain, Joseph AU - Gogain J AD - Standard BioTools, Inc., Standard BioTools, Inc., Boulder, CO, USA. FAU - Janjic, Nebojsa AU - Janjic N AUID- ORCID: 0000-0001-6811-167X AD - Standard BioTools, Inc., Standard BioTools, Inc., Boulder, CO, USA. FAU - Mandal, Rupasri AU - Mandal R AD - Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada. FAU - Jenkins, Benjamin AU - Jenkins B AUID- ORCID: 0000-0003-0038-9709 AD - Core Metabolomics and Lipidomics Laboratory, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. FAU - Browne, Hilary P AU - Browne HP AD - Wellcome Sanger Institute, Hinxton, UK. FAU - Shao, Yan AU - Shao Y AUID- ORCID: 0000-0002-8662-0504 AD - Wellcome Sanger Institute, Hinxton, UK. FAU - Rozday, Timothy AU - Rozday T AUID- ORCID: 0000-0001-7016-0665 AD - Wellcome Sanger Institute, Hinxton, UK. FAU - Stares, Mark D AU - Stares MD AD - Wellcome Sanger Institute, Hinxton, UK. FAU - Dawson, Nicholas J R AU - Dawson NJR AUID- ORCID: 0009-0009-0431-8298 AD - Wellcome Sanger Institute, Hinxton, UK. FAU - Berson, Eloise AU - Berson E AUID- ORCID: 0000-0003-1046-125X AD - Department of Anesthesiology, Perioperative and Pain Medicine, StanfordStanford University School of Medicine, Stanford, CA, USA. AD - Department of Biomedical Informatics, Stanford University School of Medicine, Stanford, CA, USA. AD - Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. FAU - Chang, Alan AU - Chang A AUID- ORCID: 0000-0003-1716-0134 AD - Department of Anesthesiology, Perioperative and Pain Medicine, StanfordStanford University School of Medicine, Stanford, CA, USA. AD - Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. AD - Department of Biomedical Informatics, Stanford University School of Medicine, Stanford, CA, USA. FAU - Kim, Yeasul AU - Kim Y AUID- ORCID: 0000-0001-8289-1297 AD - Department of Anesthesiology, Perioperative and Pain Medicine, StanfordStanford University School of Medicine, Stanford, CA, USA. AD - Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. AD - Department of Biomedical Informatics, Stanford University School of Medicine, Stanford, CA, USA. FAU - Mataraso, Samson J AU - Mataraso SJ AUID- ORCID: 0000-0003-3146-2243 AD - Department of Anesthesiology, Perioperative and Pain Medicine, StanfordStanford University School of Medicine, Stanford, CA, USA. AD - Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. AD - Department of Biomedical Informatics, Stanford University School of Medicine, Stanford, CA, USA. FAU - Shu, Chi-Hung AU - Shu CH AUID- ORCID: 0009-0009-3486-8856 AD - Department of Anesthesiology, Perioperative and Pain Medicine, StanfordStanford University School of Medicine, Stanford, CA, USA. AD - Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. AD - Department of Biomedical Informatics, Stanford University School of Medicine, Stanford, CA, USA. FAU - Phongpreecha, Thanaphong AU - Phongpreecha T AUID- ORCID: 0000-0001-9245-6686 AD - Department of Anesthesiology, Perioperative and Pain Medicine, StanfordStanford University School of Medicine, Stanford, CA, USA. AD - Department of Biomedical Informatics, Stanford University School of Medicine, Stanford, CA, USA. AD - Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA. FAU - Xue, Lei AU - Xue L AD - Department of Anesthesiology, Perioperative and Pain Medicine, StanfordStanford University School of Medicine, Stanford, CA, USA. AD - Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. AD - Department of Biomedical Informatics, Stanford University School of Medicine, Stanford, CA, USA. FAU - Saleem, Ali AU - Saleem A AD - Department of Pediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan. FAU - Singa, Benson AU - Singa B AD - Kenya Medical Research Institute, Nairobi, Kenya. FAU - Ahmed, Tahmeed AU - Ahmed T AD - Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddrb), Dhaka, Bangladesh. FAU - Voskuijl, Wieger P AU - Voskuijl WP AD - Amsterdam Institute for Global Child Health, Emma Children's hospital, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. AD - Department of Global Health, Amsterdam Centre for Global Health and Development, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands. AD - Department of Paediatrics and Child Health, Kamuzu University of Health Sciences, Blantyre, Malawi. FAU - Wishart, David S AU - Wishart DS AD - Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada. FAU - Houpt, Eric R AU - Houpt ER AD - Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA, USA. FAU - Liu, Jie AU - Liu J AD - School of Public Health, Qingdao University, Qingdao, China. FAU - Ali, Asad AU - Ali A AUID- ORCID: 0000-0001-5274-7665 AD - Department of Pediatrics and Child Health, Aga Khan University Hospital, Karachi, Pakistan. FAU - Mupere, Ezekiel AU - Mupere E AUID- ORCID: 0000-0002-8746-9009 AD - Department of Paediatrics and Child Health, College of Health Sciences, Makerere University, Kampala, Uganda. FAU - Chisti, Mohammod Jobayer AU - Chisti MJ AUID- ORCID: 0000-0001-9958-3071 AD - Nutrition and Clinical Services Division, International Centre for Diarrhoeal Disease Research, Bangladesh (icddrb), Dhaka, Bangladesh. FAU - Bandsma, Robert H J AU - Bandsma RHJ AUID- ORCID: 0000-0001-6358-4750 AD - Centre for Global Child Health, The Hospital for Sick Children, Toronto, ON, Canada. AD - Department of Biomedical Sciences, University of Malawi College of Medicine, Blantyre, Malawi. FAU - Lawley, Trevor D AU - Lawley TD AUID- ORCID: 0000-0002-4805-621X AD - Wellcome Sanger Institute, Hinxton, UK. FAU - Koulman, Albert AU - Koulman A AUID- ORCID: 0000-0001-9998-051X AD - Core Metabolomics and Lipidomics Laboratory, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, UK. AD - NIHR BRC Nutritional Biomarker Laboratory, University of Cambridge, Cambridge, UK. FAU - Lancioni, Christina L AU - Lancioni CL AUID- ORCID: 0000-0002-0821-1211 AD - Department of Pediatrics, Oregon Health and Science University, Portland, OR, USA. FAU - Aghaeepour, Nima AU - Aghaeepour N AUID- ORCID: 0000-0002-6117-8764 AD - Department of Anesthesiology, Perioperative and Pain Medicine, StanfordStanford University School of Medicine, Stanford, CA, USA. naghaeep@stanford.edu. AD - Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA. naghaeep@stanford.edu. AD - Department of Biomedical Informatics, Stanford University School of Medicine, Stanford, CA, USA. naghaeep@stanford.edu. FAU - Berkley, James A AU - Berkley JA AUID- ORCID: 0000-0002-1236-849X AD - The Childhood Acute Illness and Nutrition Network, Nairobi, Kenya. james.berkley@ndm.ox.ac.uk. AD - KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. james.berkley@ndm.ox.ac.uk. AD - Center for Tropical Medicine and Global Health, University of Oxford, Oxford, UK. james.berkley@ndm.ox.ac.uk. FAU - Walson, Judd L AU - Walson JL AUID- ORCID: 0000-0003-4836-720X AD - Global Health and Epidemiology, University of Washington, Seattle, WA, USA. jwalson1@jh.edu. AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. jwalson1@jh.edu. CN - Childhood Acute Illness and Nutrition (CHAIN) Network LA - eng PT - Journal Article DEP - 20260413 PL - England TA - Nat Commun JT - Nature communications JID - 101528555 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Multiomics MH - Child, Preschool MH - Infant MH - Female MH - Male MH - Biomarkers/blood MH - Asia, Southern MH - Acute Disease/mortality MH - Child MH - Feces/microbiology MH - Proteomics MH - Metagenomics MH - Africa South of the Sahara/epidemiology MH - Metabolomics MH - *Child Mortality PMC - PMC13249890 COIS- Competing interests: The authors declare the following competing interests: A.M., J.W., J.G., and N.J. are employees and/or stakeholders in Standard BioTools. T.P. is a cofounder of Takeoff41. T.D.L. is the co-founder and CSO of Microbiotica. N.A. is a cofounder of Takeoff AI, a member of the scientific advisory boards of January AI, Parallel Bio, Celine Therapeutics, and WellSim Biomedical Technologies, and a paid consultant for MaraBio Systems. E.B. is funded by the Wu Tsai Neurosciences Institute Knight Initiative for Brain Resilience. The rest of the authors declare no competing interests. EDAT- 2026/04/14 00:30 MHDA- 2026/06/15 11:29 PMCR- 2026/04/13 CRDT- 2026/04/13 23:15 PHST- 2025/10/15 00:00 [received] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/06/15 11:29 [medline] PHST- 2026/04/14 00:30 [pubmed] PHST- 2026/04/13 23:15 [entrez] PHST- 2026/04/13 00:00 [pmc-release] AID - 10.1038/s41467-026-69754-w [pii] AID - 69754 [pii] AID - 10.1038/s41467-026-69754-w [doi] PST - epublish SO - Nat Commun. 2026 Apr 13;17(1):5171. doi: 10.1038/s41467-026-69754-w. PMID- 41973938 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260923 IS - 2369-1999 (Electronic) IS - 2369-1999 (Linking) VI - 12 DP - 2026 Apr 13 TI - Physical Activity Monitoring in Adolescents and Young Adults With Cancer: Observational Feasibility Study. PG - e87591 LID - 10.2196/87591 [doi] LID - e87591 AB - BACKGROUND: There is a growing interest in characterizing the relationship between long-term physical activity (PA) habits and cancer-related outcomes such as treatment-related toxicities, recurrence, and complications. Wearable devices can provide critical information to achieve this goal; however, inferences are significantly influenced by device wear adherence. OBJECTIVE: This study aimed to assess the feasibility of using wearable devices to monitor short- and long-term PA in adolescent and young adult (AYA) patients with sarcoma during and after chemotherapy in a free-living environment and evaluate the ability to accurately capture changes in PA over 3 years. METHODS: A total of 63 AYA patients with sarcoma were provided with a Fitbit Charge 3 to track daily steps, sedentary time, and heart rate for up to 3 years. RESULTS: On average, during the first 30 days of follow-up, 57.1% (36/63) of patients wore their device at least 10 hours per day, and only 23.8% (15/63) of patients wore their devices thereafter. Patients spent a mean of 80% (SD 11%) of their day in a sedentary state. Despite low adherence, daily step count trends increased over time. CONCLUSIONS: This study highlights the adherence challenges met with longitudinal PA monitoring in AYA patients with sarcoma. Wearer discomfort, lost devices, and lack of data uploading compliance contributed to data missingness and attrition. Caution is warranted when relying on wearable activity trackers to inform program decisions, accurately assess PA outcomes, and monitor program adherence longitudinally without consideration of wearer bias. Alternative methods that would be more broadly accepted by AYA patients for effective long-term monitoring should be considered. CI - (c) Savannah V Rauschendorfer, Beatrice Cantoni, Michelle Audirac, Susan C Gilchrist, J Andrew Livingston, Michael E Roth, Corwin M Zigler, Eugenie S Kleinerman. Originally published in JMIR Cancer (https://cancer.jmir.org). FAU - Rauschendorfer, Savannah V AU - Rauschendorfer SV AUID- ORCID: 0000-0001-7811-5447 AD - Health, Human Performance, and Recreation, Baylor University, 1311 S 5th Street, Waco, TX, 76706, United States, 1 3175045175. FAU - Cantoni, Beatrice AU - Cantoni B AUID- ORCID: 0009-0006-0854-4864 AD - Department of Statistics and Data Sciences, The University of Texas at Austin, Austin, TX, United States. FAU - Audirac, Michelle AU - Audirac M AUID- ORCID: 0000-0001-5889-6768 AD - Department of Biostatistics, Harvard University, Boston, MA, United States. FAU - Gilchrist, Susan C AU - Gilchrist SC AUID- ORCID: 0000-0001-9624-0292 AD - Department of Medicine, Division of Cardiology, University of North Carolina School of Medicine, Chapel Hill, NC, United States. FAU - Livingston, J Andrew AU - Livingston JA AUID- ORCID: 0000-0002-1337-3282 AD - Department of Sarcoma Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. FAU - Roth, Michael E AU - Roth ME AUID- ORCID: 0000-0002-6411-8353 AD - Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. FAU - Zigler, Corwin M AU - Zigler CM AUID- ORCID: 0009-0006-0960-1656 AD - Department of Biostatistics, Brown University, Providence, RI, United States. FAU - Kleinerman, Eugenie S AU - Kleinerman ES AUID- ORCID: 0000-0003-4280-3031 AD - Department of Pediatrics, The University of Texas MD Anderson Cancer Center, Houston, TX, United States. LA - eng PT - Journal Article PT - Observational Study DEP - 20260413 PL - Canada TA - JMIR Cancer JT - JMIR cancer JID - 101666844 SB - IM MH - Humans MH - Female MH - Adolescent MH - Feasibility Studies MH - Young Adult MH - Male MH - *Exercise/physiology MH - *Sarcoma/drug therapy/physiopathology MH - Wearable Electronic Devices MH - Adult MH - *Neoplasms MH - Patient Compliance/statistics & numerical data PMC - PMC13075630 OTO - NOTNLM OT - adolescents and young adults OT - chemotherapy OT - physical activity tracking OT - sarcoma OT - wearable device COIS- Conflicts of Interest: None declared. EDAT- 2026/04/13 18:31 MHDA- 2026/04/13 18:32 PMCR- 2026/04/13 CRDT- 2026/04/13 15:13 PHST- 2025/11/11 00:00 [received] PHST- 2026/03/05 00:00 [revised] PHST- 2026/03/05 00:00 [accepted] PHST- 2026/04/13 18:32 [medline] PHST- 2026/04/13 18:31 [pubmed] PHST- 2026/04/13 15:13 [entrez] PHST- 2026/04/13 00:00 [pmc-release] AID - v12i1e87591 [pii] AID - 87591 [pii] AID - 10.2196/87591 [doi] PST - epublish SO - JMIR Cancer. 2026 Apr 13;12:e87591. doi: 10.2196/87591. PMID- 41973655 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261029 IS - 1661-7819 (Electronic) IS - 1661-7800 (Linking) VI - 123 IP - 5 DP - 2026 TI - A Pilot Randomized Controlled Trial of 24-h Webcam Access in the Neonatal Intensive Care Unit. PG - 560-567 LID - 10.1159/000551980 [doi] AB - INTRODUCTION: Although interest is increasing, 24-h live-streaming webcams are rare in neonatal intensive care units (NICUs), underscoring the need for evidence to support their use. Therefore, we evaluated the effect of 24-h webcam access on parental anxiety, bonding, and postpartum depression in a NICU setting and examined the impact on the workflows of healthcare providers. METHODS: This study was conducted from April 2023 to March 2024 in a tertiary NICU in Japan, as a pilot randomized controlled trial designed to assess feasibility and estimate the potential effect size. Parents of infants expected to stay >1 month in the NICU were enrolled. Participants were randomized to receive 24-h webcam access or no webcam access (control). The primary outcome was the Mother-to-Infant Bonding Scale (MIBS) score at 1 month after birth. Secondary outcomes included the State-Trait Anxiety Inventory (STAI), Edinburgh Postnatal Depression Scale, salivary oxytocin levels, breastfeeding volume, and staff perceptions assessed birth and at 1 month. RESULTS: Eighty parents of 41 infants were enrolled. MIBS scores did not differ significantly between groups (mothers: 2.4 +/- 2.1 vs. 2.3 +/- 1.8; fathers: 3.4 +/- 2.8 vs. 4.2 +/- 2.1). In contrast, STAI scores decreased significantly in the webcam group at 1 month (mothers: 48.0-37.3; fathers: 44.3-35.6; both p < 0.001), with a significant between-group difference (p < 0.05, difference-in-differences analysis). Staff surveys indicated that 92% of nurses supported webcam use, and no adverse events occurred. CONCLUSION: Continuous 24-h webcam access reduced parental anxiety and was well accepted by staff and families. Larger multicenter studies are warranted to validate our findings. CI - (c) 2026 S. Karger AG, Basel. FAU - Ozawa, Yuri AU - Ozawa Y AD - Department of Pediatrics, Kyorin University School of Medicine, Tokyo, Japan, ozawa-y@ncchd.go.jp. FAU - Sasagawa, Aya AU - Sasagawa A AD - Department of Pediatrics, Kyorin University School of Medicine, Tokyo, Japan. FAU - Kikuchi, Kazuto AU - Kikuchi K AD - Nursing Department, Kyorin University School of Medicine, Tokyo, Japan. FAU - Mogi, Michiyo AU - Mogi M AD - Nursing Department, Kyorin University School of Medicine, Tokyo, Japan. FAU - Douo, Nao AU - Douo N AD - Nursing Department, Kyorin University School of Medicine, Tokyo, Japan. FAU - Takemata, Kiyoko AU - Takemata K AD - Nursing Department, Kyorin University School of Medicine, Tokyo, Japan. FAU - Hosoi, Kenichiro AU - Hosoi K AD - Department of Pediatrics, Kyorin University School of Medicine, Tokyo, Japan. FAU - Naritra, Masami AU - Naritra M AD - Department of Pediatrics, Kyorin University School of Medicine, Tokyo, Japan. FAU - Kusuda, Satoshi AU - Kusuda S AD - Department of Pediatrics, Kyorin University School of Medicine, Tokyo, Japan, kusuda-satoshi@nrnj.org. AD - Neonatal Research Network of Japan, Tokyo, Japan, kusuda-satoshi@nrnj.org. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260413 PL - Switzerland TA - Neonatology JT - Neonatology JID - 101286577 RN - 50-56-6 (Oxytocin) SB - IM MH - Humans MH - Pilot Projects MH - Female MH - Infant, Newborn MH - *Intensive Care Units, Neonatal MH - *Anxiety/prevention & control/psychology MH - *Depression, Postpartum/prevention & control/psychology MH - Japan MH - Male MH - Object Attachment MH - Adult MH - Breast Feeding MH - Mothers/psychology MH - Mother-Child Relations MH - *Parents/psychology MH - Oxytocin/analysis OTO - NOTNLM OT - Anxiety OT - Edinburgh Postnatal Depression Scale OT - Neonatal intensive care units OT - Oxytocin OT - Postpartum depression EDAT- 2026/04/13 18:32 MHDA- 2026/10/27 17:29 CRDT- 2026/04/13 13:24 PHST- 2026/01/14 00:00 [received] PHST- 2026/04/08 00:00 [accepted] PHST- 2026/10/27 17:29 [medline] PHST- 2026/04/13 18:32 [pubmed] PHST- 2026/04/13 13:24 [entrez] AID - 000551980 [pii] AID - 10.1159/000551980 [doi] PST - ppublish SO - Neonatology. 2026;123(5):560-567. doi: 10.1159/000551980. Epub 2026 Apr 13. PMID- 41972900 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260928 IS - 1552-5732 (Electronic) IS - 0890-3344 (Print) IS - 0890-3344 (Linking) VI - 42 IP - 3 DP - 2026 Aug TI - The Evidence Informing Hypoglycaemia Treatment Thresholds in Asymptomatic, Term, Well Newborns: A Review of Literature and Critical Appraisal of Methodological Challenges. PG - 569-584 LID - 10.1177/08903344261426051 [doi] AB - BACKGROUND: There is worldwide inconsistency in blood glucose level treatment thresholds for hypoglycaemia in healthy, term asymptomatic newborns. Differing testing policies and broader inclusion criteria from maternal conditions have increased the incidence of testing. The use of human milk substitutes to treat hypoglycaemia may adversely influence the establishment of breastfeeding and early bonding between mother and baby. RESEARCH AIM: To determine if current research informs a high-quality evidence-based therapeutic treatment threshold for hypoglycaemia in well, asymptomatic newborns in the first 24 hours of life. METHODS: A comprehensive review accessing CINAHL, Medline, Scopus, Web of Science, Cochrane, and CENTRAL databases was performed. Original English-language quantitative studies reporting hypoglycemic treatment thresholds, and their neurodevelopmental outcomes for over 11,000 newborns, were appraised for quality and validity using independent screening and Crowe's Quality Appraisal Tool. RESULTS: Thirteen papers were included with outcomes grouped into two categorical definitions of hypoglycaemia (statistical and neurodevelopmental). Nine of the included studies were assessed as producing low quality evidence, with a moderate to high risk of bias, unreliable methodology, and smaller sample sizes. One study provided high quality evidence, with a sample size of > 1000 newborns, that a blood glucose threshold of 2.09 mmol/L was a potentially safe treatment threshold. CONCLUSION: Published high quality research is lacking to inform a therapeutic treatment threshold for hypoglycaemia in well, term asymptomatic newborns in the first 24 hours. Current treatment may interfere with breastfeeding and bonding. Rigorous research is required to establish a safe threshold and inform future practice. FAU - Hodges, Kylie AU - Hodges K AUID- ORCID: 0009-0000-5716-4776 AD - University of Canberra, ACT Australia. FAU - Trenaman, Samantha AU - Trenaman S AD - NSW Health, NSW, Australia. FAU - Bushell, Mary AU - Bushell M AD - University of Canberra, ACT Australia. FAU - Bazargan, Maryam AU - Bazargan M AD - University of Canberra, ACT Australia. FAU - Atchan, Marjorie AU - Atchan M AD - University of Canberra, ACT Australia. LA - eng PT - Journal Article PT - Review DEP - 20260413 PL - United States TA - J Hum Lact JT - Journal of human lactation : official journal of International Lactation Consultant Association JID - 8709498 RN - 0 (Blood Glucose) SB - IM MH - Humans MH - *Hypoglycemia/drug therapy/therapy/diagnosis MH - Infant, Newborn MH - Blood Glucose/analysis MH - Female MH - Breast Feeding PMC - PMC13615315 OTO - NOTNLM OT - blood glucose OT - blood sugar level OT - hypoglycaemia OT - lactation OT - narrative review OT - neonatal OT - newborn OT - treatment thresholds COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/04/13 12:37 MHDA- 2026/09/25 11:44 PMCR- 2026/09/26 CRDT- 2026/04/13 09:43 PHST- 2026/09/25 11:44 [medline] PHST- 2026/04/13 12:37 [pubmed] PHST- 2026/04/13 09:43 [entrez] PHST- 2026/09/26 00:00 [pmc-release] AID - 10.1177_08903344261426051 [pii] AID - 10.1177/08903344261426051 [doi] PST - ppublish SO - J Hum Lact. 2026 Aug;42(3):569-584. doi: 10.1177/08903344261426051. Epub 2026 Apr 13. PMID- 41972313 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1533-0338 (Electronic) IS - 1533-0346 (Print) IS - 1533-0338 (Linking) VI - 25 DP - 2026 Jan-Dec TI - Dosimetric Performance Analysis of Pediatric Based Halcyon Volumetric Arc Therapy-Based Lung-Sparing Total Body Irradiation. PG - 15330338261443068 LID - 10.1177/15330338261443068 [doi] LID - 15330338261443068 AB - IntroductionHalcyon O-ring linear accelerators (linacs) provide a robust and efficient radiotherapy option for clinics. Interest in volumetric arc therapy (VMAT) based total body irradiation (TBI) has grown, with most current VMAT TBI protocols employing C-arm linacs; however, the feasibility of Halcyon-based VMAT TBI has been recently hypothesized. This study investigates the planning feasibility and dosimetric quality of VMAT-based, lung-sparing TBI delivered by Halcyon linac to pediatric patients.Methods10 pediatric patients (94 - 134 cm in height) previously treated to 12 Gy TBI through traditional 3D planning techniques were retrospectively replanned on a Halcyon linac. 2-3 VMAT plans containing 4-6 isocenters each with 2-2.5 arcs were created to treat the head, abdomen, and legs, with 1-2 static-gantry treatment matching areas being used between VMAT planning regions.ResultsLung doses were significantly reduced below the clinically significant level of 8 Gy, achieving mean doses of 6.66 +/- 0.52 Gy (55.5% +/- 4.3%). Target coverage was achieved with D90% of 77.5% +/- 12.5% and homogeneity indexes of 0.92 +/- 0.1. Planning time took 5-6 hours per patient: 1.5 hours for contouring and field placement and 3.5-4.5 hours for plan optimization and dose calculations. Using a dose rate of 800 MU/min field delivery time took an average of 20.8 +/- 7 minutes with average portal dosimetry quality assurance passing rates of 99.6% and 99.9% for 2%/2mm and 3%/3mm gamma analysis metrics.ConclusionVMAT lung sparing TBI via Halcyon linacs is feasible and dosimetrically acceptable, with greatest applicability to smaller patients (<100 cm). Planning and setup complexity increases dramatically for larger patients (>100 cm) due to the smaller maximum field sizes (28 x 28 cm2) achievable. Future developments in software-based automations for target delineation, multiple field matching, and plan optimization could allow for more practicable treatment of larger patients. FAU - Haertter, Allison AU - Haertter A AD - New York Proton Center, New York, NY. RINGGOLD: 672877 FAU - Goel, Keshav AU - Goel K AUID- ORCID: 0009-0008-3070-9463 AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. RINGGOLD: 14640 FAU - Niculcea, Jacob AU - Niculcea J AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. RINGGOLD: 14640 FAU - Li, Taoran AU - Li T AD - Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA. RINGGOLD: 6572 FAU - Hill-Kayser, Christine E AU - Hill-Kayser CE AD - Department of Radiation Oncology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA. RINGGOLD: 6572 FAU - Plastaras, John AU - Plastaras J AD - Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA. RINGGOLD: 6572 FAU - LaRiviere, Michael J AU - LaRiviere MJ AD - Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA. RINGGOLD: 6572 FAU - Kim, Michele M AU - Kim MM AD - Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA. RINGGOLD: 6572 LA - eng PT - Journal Article DEP - 20260413 PL - United States TA - Technol Cancer Res Treat JT - Technology in cancer research & treatment JID - 101140941 SB - IM MH - Humans MH - *Radiotherapy Planning, Computer-Assisted/methods MH - *Radiotherapy, Intensity-Modulated/methods MH - Radiotherapy Dosage MH - *Whole-Body Irradiation/methods MH - Radiometry/methods MH - *Lung/radiation effects MH - Child MH - Particle Accelerators MH - *Organ Sparing Treatments/methods MH - *Neoplasms/radiotherapy MH - Male MH - Female MH - Adolescent MH - Child, Preschool MH - Retrospective Studies MH - Organs at Risk/radiation effects PMC - PMC13080152 OTO - NOTNLM OT - body mass index OT - cancer OT - cancer treatment OT - computed tomography, CT OT - delivery OT - lung OT - lung cancer OT - radiation OT - radiation therapy COIS- Declaration of Conflicting InterestsThe authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Dr. Taoran Li: reports employment with Varian Medical Systems. EDAT- 2026/04/13 12:37 MHDA- 2026/04/13 12:38 PMCR- 2026/04/13 CRDT- 2026/04/13 07:02 PHST- 2026/04/13 12:38 [medline] PHST- 2026/04/13 12:37 [pubmed] PHST- 2026/04/13 07:02 [entrez] PHST- 2026/04/13 00:00 [pmc-release] AID - 10.1177_15330338261443068 [pii] AID - 10.1177/15330338261443068 [doi] PST - ppublish SO - Technol Cancer Res Treat. 2026 Jan-Dec;25:15330338261443068. doi: 10.1177/15330338261443068. Epub 2026 Apr 13. PMID- 41970416 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260413 LR - 20260813 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 4 DP - 2026 Apr TI - Maternal Knowledge, Attitudes, and Practices Toward Complementary Feeding in Rural Bangladesh: A Cross-Sectional Study. PG - e72318 LID - 10.1002/hsr2.72318 [doi] LID - e72318 AB - BACKGROUND: Complementary Feeding is essential for child growth and development, particularly between 6 and 24 months of age, when nutritional demands exceed what breast milk alone can provide. However, persistent gaps remain between maternal knowledge and actual feeding practices in many low- and middle-income countries (LMICs). Inappropriate complementary feeding contributes significantly to child malnutrition in Bangladesh. This study examined the knowledge, attitudes, and practices (KAP) of mothers regarding complementary feeding in a rural area of Tangail, Bangladesh. METHODS: A cross-sectional survey was conducted among 160 mothers of infants aged 6-24 months. Data were collected using a structured questionnaire, guided by World Health Organisation (WHO) recommendations and previously validated KAP instruments. RESULTS: Most mothers (93.1%) had introduced complementary feeding to their children, and 82.5% correctly identified the appropriate age for initiating. Only 66.9% practised adequate hygiene in food preparation, and 93.1% affirmed the importance of nutritious complementary food for proper growth and development. Homemade foods were preferred by 89.4% of mothers, though 16.3% introduced formula milk early. Attitudes toward feeding during illness were mixed. However, 60% of mothers reported offering extra food during illness, which aligns with WHO recommendations. Mothers with higher education and income demonstrated significantly more positive attitudes, and employed mothers and those in nuclear families showed significantly better complementary feeding practices. CONCLUSION: This study found while most mothers in rural Bangladesh know when to initiate complementary feeding, substantial gaps persist in hygiene and feeding practices. Increased community-based and family-centered nutrition education, as well as the integration of growth monitoring into maternal and child health services, are recommended to address observed practice gaps. Further research should explore barriers to applying knowledge in practice. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Islam, Rajib Ul AU - Islam RU AD - Department of Government and Politics Jahangirnagar University Savar Dhaka Bangladesh. FAU - Mili, Morsheda Alam AU - Mili MA AD - Department of Public Health and Informatics Jahangirnagar University Savar Dhaka Bangladesh. FAU - Kamal, Sabkat AU - Kamal S AUID- ORCID: 0000-0002-6548-4937 AD - Department of Urban and Regional Planning Jahangirnagar University Savar Dhaka Bangladesh. FAU - Taher, Labina AU - Taher L AD - Kelvin Grove State College Brisbane Queensland Australia. FAU - Noshin, Fariha AU - Noshin F AD - Government College of Applied Human Science Dhaka Bangladesh. FAU - Moonajilin, Mst Sabrina AU - Moonajilin MS AUID- ORCID: 0000-0003-4135-9960 AD - Department of Public Health and Informatics Jahangirnagar University Savar Dhaka Bangladesh. AD - Queensland University of Technology, Psychology and counselling Brisbane Australia. LA - eng PT - Journal Article DEP - 20260408 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC13062521 OTO - NOTNLM OT - child nutrition OT - complementary feeding OT - maternal knowledge COIS- The authors declare no conflicts of interest. EDAT- 2026/04/13 18:17 MHDA- 2026/04/13 18:18 PMCR- 2026/04/08 CRDT- 2026/04/13 06:34 PHST- 2025/06/08 00:00 [received] PHST- 2025/12/05 00:00 [revised] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/04/13 18:18 [medline] PHST- 2026/04/13 18:17 [pubmed] PHST- 2026/04/13 06:34 [entrez] PHST- 2026/04/08 00:00 [pmc-release] AID - HSR272318 [pii] AID - 10.1002/hsr2.72318 [doi] PST - epublish SO - Health Sci Rep. 2026 Apr 8;9(4):e72318. doi: 10.1002/hsr2.72318. eCollection 2026 Apr. PMID- 41970389 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260413 LR - 20260813 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 13 DP - 2026 TI - Comparative performance of multiple novel obesity indices for MAFLD screening in Chinese children: the body roundness index as a practical predictor. PG - 1773506 LID - 10.3389/fmed.2026.1773506 [doi] LID - 1773506 AB - In recent years, as childhood obesity rates soar globally, there has been a concomitant increase in the prevalence of metabolic dysfunction-associated fatty liver disease (MAFLD). The intent of this analysis is to explore the correlation between four novel obesity indices and pediatric MAFLD, and to compare their varying screening performance for MAFLD. We used data from the Wuxi (China) Children's Nutrition and Health cohort. Logistic regression and restricted cubic spline (RCS) were employed to assess the associations between the obesity indices, including visceral adiposity index (VAI), lipid accumulation product (LAP), body roundness index (BRI), and weight-adjusted waist index (WWI) with MAFLD in children. Furthermore, Receiver operating characteristic (ROC) curve analysis was used to evaluate the predictive performance of the four novel obesity indices, and DeLong's test was applied to compare the AUC of the best-performing index (BRI) with those of traditional anthropometric measures (BMI, WC, and WHtR). A total of 1,214 children (aged 6-14 years) were enrolled in this study, with a mean age of 10.3 years and a boy proportion of 56.4%. Among them, 205 (16.8%) were diagnosed with MAFLD, while the remaining 1,009 (83.1%) served as controls. The multivariate logistic regression revealed that the VAI, LAP, BRI and WWI displayed a marked association with MAFLD in children (all p < 0.001). Among them, BRI exhibited high and consistent screening performance for pediatric MAFLD across all analyzed subgroups. For instance, in the subgroup with CAP >/= 248 dB/m, it achieved an AUC of 0.929 (95% CI: 0.913-0.945), comparable to traditional BMI and WHtR, and significantly outperformed WC. Our findings demonstrated four the novel obesity indices are significantly associated with MAFLD in children. The BRI emerges as a simple, reliable, and clinically useful screening tool that captures visceral fat distribution and may aid in early risk stratification. CI - Copyright (c) 2026 Fan, Tang, Lin, Zhang, Zheng, Zhu, Zhang, Zhu and Li. FAU - Fan, Minhao AU - Fan M AD - Wuxi Key Laboratory of Genetic and Metabolic Diseases in Children, Department of Paediatrics, Wuxi Children's Hospital, Affiliated Children's Hospital of Jiangnan University, Wuxi, Jiangsu, China. FAU - Tang, Cai AU - Tang C AD - Wuxi Key Laboratory of Genetic and Metabolic Diseases in Children, Department of Paediatrics, Wuxi Children's Hospital, Affiliated Children's Hospital of Jiangnan University, Wuxi, Jiangsu, China. FAU - Lin, Shibo AU - Lin S AD - Department of Bariatric and Metabolic Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. FAU - Zhang, Jiahui AU - Zhang J AD - Department of Pediatric Laboratory, Wuxi Key Laboratory of Genetic and Metabolic Diseases in Children, Wuxi Children's Hospital, Affiliated Children's Hospital of Jiangnan University, Wuxi, Jiangsu, China. FAU - Zheng, Xiaowei AU - Zheng X AD - Public Health Research Center, Department of Public Health and Preventive Medicine, Wuxi School of Medicine Jiangnan University, Wuxi, Jiangsu, China. FAU - Zhu, Lihong AU - Zhu L AD - Wuxi Key Laboratory of Genetic and Metabolic Diseases in Children, Department of Paediatrics, Wuxi Children's Hospital, Affiliated Children's Hospital of Jiangnan University, Wuxi, Jiangsu, China. FAU - Zhang, Le AU - Zhang L AD - Wuxi Key Laboratory of Genetic and Metabolic Diseases in Children, Department of Paediatrics, Wuxi Children's Hospital, Affiliated Children's Hospital of Jiangnan University, Wuxi, Jiangsu, China. FAU - Zhu, Xiaomin AU - Zhu X AD - Department of Pediatric Surgery, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, Jiangsu, China. FAU - Li, Yun AU - Li Y AD - Department of Pediatric Laboratory, Wuxi Key Laboratory of Genetic and Metabolic Diseases in Children, Wuxi Children's Hospital, Affiliated Children's Hospital of Jiangnan University, Wuxi, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260326 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC13062208 OTO - NOTNLM OT - MAFLD OT - Wuxi (China) Children's Nutrition and Health cohort OT - children OT - obesity indices OT - screening performance COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/13 18:17 MHDA- 2026/04/13 18:18 PMCR- 2026/03/26 CRDT- 2026/04/13 06:33 PHST- 2025/12/22 00:00 [received] PHST- 2026/03/04 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/04/13 18:18 [medline] PHST- 2026/04/13 18:17 [pubmed] PHST- 2026/04/13 06:33 [entrez] PHST- 2026/03/26 00:00 [pmc-release] AID - 10.3389/fmed.2026.1773506 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Mar 26;13:1773506. doi: 10.3389/fmed.2026.1773506. eCollection 2026. PMID- 41969967 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260413 LR - 20260813 IS - 1300-0667 (Print) IS - 1309-4866 (Electronic) IS - 1300-0667 (Linking) VI - 63 DP - 2026 TI - Binge Eating Disorder in Bipolar I Disorder: Prevalence, Childhood Trauma, and Clinical Correlates. PG - 380-386 LID - 10.29399/npa.29253 [doi] AB - INTRODUCTION: Bipolar I disorder (BD-I) frequently co-occurs with eating disorders, particularly binge eating disorder (BED), which may adversely affect the clinical course, including recurrence risk and functional impairment. Research exploring the specific association between BED and childhood trauma (CT) in BD-I remains limited. This study aimed to investigate the prevalence of BED among euthymic BD-I patients and to examine its associations with CT and clinical characteristics. METHODS: This cross-sectional study recruited 150 euthymic BD-I patients diagnosed according to DSM-5 criteria. Sociodemographic data, illness-related variables, psychiatric comorbidities, and medication use were collected. Binge eating disorder was assessed through the Structured Clinical Interview for DSM-5 (SCID-5) and validated eating disorder scales. Childhood trauma was evaluated using the Childhood Trauma Questionnaire (CTQ). Statistical analyses included group comparisons and multivariate logistic regression. RESULTS: Binge eating disorder prevalence in the sample was 19.3%. Female sex, higher body weight, and elevated body mass index were significantly associated with BED. Compared to patients without BED, those with BED reported higher rates of psychotic episodes, rapid cycling, and suicide attempts. Childhood trauma questionnaire total scores, particularly physical abuse subscale scores, were significantly higher in the BED group. Logistic regression analysis revealed that female sex, a history of physical abuse, and higher eating disorder scale scores were independent predictors of BED. CONCLUSIONS: Our findings indicate that BED constitutes a distinct and clinically consequential profile in euthymic BD-I patients, one that is strongly shaped by both increased illness severity and CT. This relationship underlines the necessity of integrating systematic assessments of eating pathology and trauma exposure into the standard clinical evaluation of BD-I patients to ensure timely recognition and the delivery of effective, precision-based therapeutic interventions. CI - Copyright: (c) 2026 Turkish Neuropsychiatric Society. FAU - Karabiyik, Binnur AU - Karabiyik B AD - Basaksehir Cam Sakura City Hospital, Department of Psychiatry, Istanbul, Turkiye. FAU - Onur, Ozge Sahmelikoglu AU - Onur OS AD - Tekirdag Namik Kemal University, Department of Psychiatry, Tekirdag, Turkiye. FAU - Karamustafalioglu, Nesrin AU - Karamustafalioglu N AD - 16th Psychiatry Clinic, Bakirkoy Prof. Dr. Mazhar Osman Trainig and Research Hospital for Psychiatry, Neurology and Neurosurgery, Istanbul, Turkiye. LA - eng PT - Journal Article DEP - 20260326 PL - Turkey TA - Noro Psikiyatr Ars JT - Noro psikiyatri arsivi JID - 9426194 PMC - PMC13065102 OTO - NOTNLM OT - Binge eating disorder OT - bipolar disorder OT - childhood trauma OT - eating disorder COIS- Conflict of Interest: The authors declared that there is no conflict of interest. EDAT- 2026/04/13 18:17 MHDA- 2026/04/13 18:18 PMCR- 2026/03/26 CRDT- 2026/04/13 06:30 PHST- 2025/10/01 00:00 [received] PHST- 2026/01/02 00:00 [accepted] PHST- 2026/04/13 18:18 [medline] PHST- 2026/04/13 18:17 [pubmed] PHST- 2026/04/13 06:30 [entrez] PHST- 2026/03/26 00:00 [pmc-release] AID - archneuro-63-380 [pii] AID - 10.29399/npa.29253 [doi] PST - epublish SO - Noro Psikiyatr Ars. 2026 Mar 26;63:380-386. doi: 10.29399/npa.29253. eCollection 2026. PMID- 41969721 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260413 LR - 20260813 IS - 0970-0218 (Print) IS - 1998-3581 (Electronic) IS - 0970-0218 (Linking) VI - 51 IP - Suppl 1 DP - 2026 Feb TI - Weight Perception and Bullying among Overweight and Obese Students (Age 6-16 Years) in Amritsar District. PG - S137-S143 LID - 10.4103/ijcm.ijcm_523_24 [doi] AB - BACKGROUND: Childhood obesity is a serious global health crisis with serious and long-lasting consequences for children's physical and mental health. The persistence of obesity and accompanying health complications is partly due to parents' and children's misperceptions about their weight status. Furthermore, obesity is associated with increased bullying and negative social experiences among school-aged children. OBJECTIVES: The study aims to evaluate the self-perception of weight among overweight and obese students aged 6-16 years in Amritsar and to explore the relationship between obesity and bullying. METHODS: The Amritsar district was selected through the lottery method of simple random sampling for this cross-sectional study, which was carried out between October 2019 and April 2020. Out of 4226 students, 355 overweight and obese students were interviewed regarding their weight perceptions and social impact. After being fully informed of the study's goals and methods, guardians and students gave their written consent to take part. A predesigned, validated, semistructured questionnaire was used to interview mothers of students aged 6 to 11 and students aged 12 to 16. Statistical analysis was done using Chi-square and logistic regression tests. RESULTS: 70.7% received weight loss suggestions from family, with 39.4% from parents. Despite 52.1% attempting weight loss, many found it ineffective. Only 47.3% deemed school education on weight management sufficient. Notably, 53.2% reported their social life has been impacted negatively due to their weight, and 29.9% experienced sadness. Bullying was more prevalent among boys, with 72.9% reporting such experiences. Regression analysis indicated that obesity-related sadness and being aged 14-16 years increased odds of bullying. CONCLUSIONS: Bullying is more prevalent in obese boys, and it is more likely to affect students of age group 14-16 years and those who are depressed about their weight. Many students and their mothers misperceive weight status. Improvements to school canteen food quality, nutrition seminars, and physical education programs are among the recommendations. CI - Copyright: (c) 2026 Indian Journal of Community Medicine. FAU - Batish, Rohit AU - Batish R AD - Department of Community Medicine, GMC and RH, Patiala, Punjab, India. FAU - Oberoi, Simmi AU - Oberoi S AD - Department of Community Medicine, GMC and RH, Patiala, Punjab, India. FAU - Ghosh, Sataparna AU - Ghosh S AD - Department of Community Medicine, GMC and RH, Patiala, Punjab, India. FAU - Singh, Aman Dev AU - Singh AD AD - Department of Community Medicine, GMC and RH, Patiala, Punjab, India. FAU - Ashish, Sneh AU - Ashish S AD - Department of Dental Research Cell, Dr. DY Patil Dental College and Hospital, Dr. DY Patil Vidyapeeth, Pimpri, Pune, Maharashtra, India. LA - eng PT - Journal Article DEP - 20260112 PL - India TA - Indian J Community Med JT - Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine JID - 9315574 PMC - PMC13068427 OTO - NOTNLM OT - Bullying OT - overweight OT - pediatric obesity OT - weight perceptions COIS- There are no conflicts of interest. EDAT- 2026/04/13 18:17 MHDA- 2026/04/13 18:18 PMCR- 2026/02/01 CRDT- 2026/04/13 06:28 PHST- 2024/07/24 00:00 [received] PHST- 2025/09/18 00:00 [accepted] PHST- 2026/04/13 18:18 [medline] PHST- 2026/04/13 18:17 [pubmed] PHST- 2026/04/13 06:28 [entrez] PHST- 2026/02/01 00:00 [pmc-release] AID - IJCM-51-137 [pii] AID - 10.4103/ijcm.ijcm_523_24 [doi] PST - ppublish SO - Indian J Community Med. 2026 Feb;51(Suppl 1):S137-S143. doi: 10.4103/ijcm.ijcm_523_24. Epub 2026 Jan 12. PMID- 41969713 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260413 LR - 20260813 IS - 0970-0218 (Print) IS - 1998-3581 (Electronic) IS - 0970-0218 (Linking) VI - 51 IP - Suppl 1 DP - 2026 Feb TI - Exploring Complementary Feeding Practices and their Determinants among 6-24 month old Children: A Cross Sectional Study. PG - S45-S52 LID - 10.4103/ijcm.ijcm_841_24 [doi] AB - CONTEXT: Children under two years should be provided with sufficient and suitable complementary foods and breastmilk to ensure proper growth and development. However, their diets fall short in quality, quantity, and frequency. AIMS: To assess complementary feeding practices and their associated predictors in children aged 6-24 months. METHODS AND MATERIAL: A cross-sectional survey was conducted between June 2023 and December 2023, where mothers of 400 children of 6-24 months of age were interviewed. Previous day diets of children were recorded using the open diet recall method on a pretested, validated, and semi-structured questionnaire. Nine indicators given by the World Health Organization were subsequently calculated. The factors influencing complementary feeding were analyzed using multivariate logistic regression. RESULTS: The mean age for the introduction of solid, semi-solid, and soft foods was 6.05 +/- 1.676 months. Timely initiation of complementary foods was reported in 73% of subjects. Minimum acceptable diet (MAD), minimum diet diversity (MDD), and minimum meal frequency (MMF) were achieved in 15.5%, 16.5%, and 82.25% of subjects, respectively. While a substantial number of children consume unhealthy foods (52%) and sweet beverages (24.5%), a notable percentage does not consume fruits or vegetables (43.5%), eggs (6.8%), or flesh foods (0%). A smaller proportion of females receive a timely introduction of complementary foods compared to males [AOR: 0.321 (CI: 0.199-0.518)]. Mothers who completed higher levels of studies introduced solid foods timely compared to others [High school AOR: 1.937 (CI: 1.097-3.418); graduate and above AOR: 2.569 (CI: 1.132-5.833)]. MDD is significantly associated with the age of subjects [9-12 months AOR: 8.05 (CI: 1.02-63.41); 13-24 months AOR: 13.85 (CI: 1.84-104.36)]. MMF is significantly linked with age of subjects [13-24 months AOR: 14.364 (CI 5.89-35.01)], mother's occupation [Working mothers AOR: 0.29 (CI 0.09-0.89)], live births [>/=2 live births AOR: 2.07 (CI 1.10-3.89)], hours away from child [<5 hours AOR: 3.96 (CI: 1.11-14.14)], and socio-economic status [Upper middle AOR: 5.29 (CI: 1.54-18.15)]. MAD is significantly influenced by the age of subjects [13-24 months AOR: 13.72 (CI: 1.81-104.01)] and the type of family [joint family AOR: 2.04 (CI: 1.09-3.81)]. CONCLUSIONS: There is a concern about the critical importance of timely initiation of complementary feeding and the adequacy of diets provided to young children. One-fourth to half of children under two years consume more sweet beverages and unhealthy foods while missing out on micronutrient-rich foods. Being male and having a mother with higher education significantly influence the timely introduction of complementary foods. As the child's age increases, so does their meal diversity, frequency, and adequacy. Working mothers with more time away from children, with less experience of raising children and belonging to poor socio-economic status, have adverse effects on meal frequency. Contrarily, children of joint families receive an adequate diet. CI - Copyright: (c) 2025 Indian Journal of Community Medicine. FAU - Rai, Sunvir K AU - Rai SK AD - Department of Community Medicine, Government Medical College, Patiala, Punjab, India. FAU - Oberoi, Simmi AU - Oberoi S AD - Department of Community Medicine, Government Medical College, Patiala, Punjab, India. FAU - Gill, Shahirajpreet K AU - Gill SK AD - MBBS Student, Government Medical College, Patiala, Punjab, India. FAU - Kaur, Ravneet AU - Kaur R AD - MBBS Student, Government Medical College, Patiala, Punjab, India. LA - eng PT - Journal Article DEP - 20251110 PL - India TA - Indian J Community Med JT - Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine JID - 9315574 PMC - PMC13068425 OTO - NOTNLM OT - Child nutrition OT - complementary feeding OT - diet OT - feeding behavior OT - infants COIS- There are no conflicts of interest. EDAT- 2026/04/13 18:17 MHDA- 2026/04/13 18:18 PMCR- 2026/02/01 CRDT- 2026/04/13 06:28 PHST- 2024/11/12 00:00 [received] PHST- 2025/05/23 00:00 [accepted] PHST- 2026/04/13 18:18 [medline] PHST- 2026/04/13 18:17 [pubmed] PHST- 2026/04/13 06:28 [entrez] PHST- 2026/02/01 00:00 [pmc-release] AID - IJCM-51-45 [pii] AID - 10.4103/ijcm.ijcm_841_24 [doi] PST - ppublish SO - Indian J Community Med. 2026 Feb;51(Suppl 1):S45-S52. doi: 10.4103/ijcm.ijcm_841_24. Epub 2025 Nov 10. PMID- 41969616 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260413 LR - 20260813 IS - 2381-4683 (Electronic) IS - 2381-4683 (Linking) VI - 11 IP - 1 DP - 2026 Jan-Jun TI - Translation, Adaptation, and Validation of the French Version of the Low Literacy Decisional Conflict Scale in Adolescents. PG - 23814683261438738 LID - 10.1177/23814683261438738 [doi] LID - 23814683261438738 AB - Purpose. We aimed 1) to translate and adapt the English version of Low Literacy Decisional Conflict Scale (LL-DCS) into French and 2) to assess its psychometric properties in adolescents. Methods. The original LL-DCS was translated into French by 2 independent translators, with discrepancies resolved by a multidisciplinary team. The reconciled version was back-translated into English by 2 other translators to ensure accuracy. We tested the prefinal version among 14 adolescents, who evaluated the clarity of the items. Second, we conducted psychometric testing of the final version among 85 adolescents participating in a pilot study evaluating a decision aid for contraception and menstrual management. Participants completed the French version of LL-DCS before (T0) and after (T1) their clinical encounter. We assessed internal consistency with Cronbach's alphas and model fit with confirmatory factorial analyses. We evaluated discriminant validity by comparing scores at T0 and T1 based on participants' responses regarding treatment preference. Results. Internal consistency of the French LL-DCS was acceptable, with a Cronbach's alpha of 0.72 at both T0 and T1, although there was variability in reliability at the subscale level. Model fit was adequate at T0, indicating good factor validity. There was evidence for the original 4-factor model at T0, but exploratory analysis suggested a 3-factor solution with Informed and Values Clarity as one factor. Discriminant validity was strong, as the scale distinguished between adolescents who had decided on treatment and those who remained undecided. Conclusion. The French version of the LL-DCS demonstrates satisfactory psychometric properties, including internal consistency, factor validity, and discriminant validity. However, caution should be exercised when interpreting individual subscales, as their internal consistency is somewhat lower than the original English version of LL-DCS. HIGHLIGHTS: We translated, adapted, and tested the French version of Low Literacy Decisional Conflict Scale in adolescents.The French version of the Low Literacy Decisional Conflict Scale is adapted to people with limited literacy skills.We hope that it might facilitate the participation of vulnerable populations in clinical research projects. CI - (c) The Author(s) 2026. FAU - Moussaoui, Dehlia AU - Moussaoui D AUID- ORCID: 0000-0002-6987-4916 AD - Division of General Pediatrics, Department of Pediatrics, Obstetrics and Gynecology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. FAU - Crofts, Victoria L AU - Crofts VL AD - Division of Gynecology, Department of Pediatrics, Obstetrics and Gynecology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. FAU - Silvestrini, Nicolas AU - Silvestrini N AD - Clinical Research Platform - Pediatrics, Gynecology and Obstetrics, Department of Pediatrics, Obstetrics and Gynecology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. FAU - Agoritsas, Thomas AU - Agoritsas T AD - Division of General Internal Medicine, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland. AD - Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada. AD - MAGIC Evidence Ecosystem Foundation, Oslo, Norway. FAU - Merglen, Arnaud AU - Merglen A AD - Division of General Pediatrics, Department of Pediatrics, Obstetrics and Gynecology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. FAU - Yaron, Michal AU - Yaron M AUID- ORCID: 0000-0003-0665-4710 AD - Division of Gynecology, Department of Pediatrics, Obstetrics and Gynecology, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland. LA - eng PT - Journal Article DEP - 20260408 PL - United States TA - MDM Policy Pract JT - MDM policy & practice JID - 101707716 PMC - PMC13065280 OTO - NOTNLM OT - adolescents OT - decisional conflict scale OT - low literacy OT - translation OT - validation COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Financial support for this study was provided in part by a grant "cheffe de clinique scientifique" (Dehlia Moussaoui) from the University of Geneva, Geneva, Switzerland. Dehlia Moussaoui and Michal Yaron are supported by a grant from the "Fondation privee," Geneva University Hospitals, Geneva, Switzerland. The funding agreement ensured the authors' independence in designing the study, interpreting the data, writing, and publishing the report. EDAT- 2026/04/13 18:17 MHDA- 2026/04/13 18:18 PMCR- 2026/04/08 CRDT- 2026/04/13 06:27 PHST- 2025/06/23 00:00 [received] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/04/13 18:18 [medline] PHST- 2026/04/13 18:17 [pubmed] PHST- 2026/04/13 06:27 [entrez] PHST- 2026/04/08 00:00 [pmc-release] AID - 10.1177_23814683261438738 [pii] AID - 10.1177/23814683261438738 [doi] PST - epublish SO - MDM Policy Pract. 2026 Apr 8;11(1):23814683261438738. doi: 10.1177/23814683261438738. eCollection 2026 Jan-Jun. PMID- 41969183 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260926 IS - 1463-1326 (Electronic) IS - 1462-8902 (Print) IS - 1462-8902 (Linking) VI - 28 IP - 7 DP - 2026 Jul TI - Accuracy of ChatGPT, Gemini, Claude and DeepSeek in Carbohydrate Counting. PG - 5627-5636 LID - 10.1111/dom.70747 [doi] AB - AIMS: To evaluate the accuracy of four general-purpose artificial intelligence (AI) models-ChatGPT (OpenAI), Gemini (Google), Claude (Anthropic) and DeepSeek (DeepSeek AI)-in calculating the carbohydrate content of meals compared with clinicians-calculated reference values. MATERIALS AND METHODS: The primary endpoint was equivalence between clinicians and AI-generated calculations within an error margin of +/-5%. One-hundred twenty-four meals were analysed, equally distributed among breakfast, lunch, dinner and snacks. Carbohydrate contents were jointly determined by two paediatric diabetologists and one clinical nutritionist using the USDA FoodData Central and CREA Italian Food Composition Tables. Each AI model received identical, standardized prompts in English describing the meals. Statistical analyses included the Two One-Sided Tests procedure, the Bland-Altman plots, the Wilcoxon signed-rank and the Spearman correlations. RESULTS: The clinicians' median carbohydrate content was 30.32 g. Model medians were 30.75 g (ChatGPT), 30.40 g (Gemini), 29.75 g (DeepSeek) and 29.25 g (Claude). ChatGPT showed the smallest bias, the narrowest limits of agreement, and the highest correlation with clinicians' calculation. Only ChatGPT met the predefined +/-5% equivalence criterion, whereas Gemini and DeepSeek achieved equivalence within a +/-10% margin. Claude displayed the largest negative bias and the widest dispersion. CONCLUSIONS: ChatGPT most accurately approximated clinicians' carbohydrate calculation among the tested AI models and fulfilled strict clinical equivalence criteria. Although the other models tended to underestimate carbohydrate content, their mean deviations remained within clinically acceptable limits. These findings suggest that AI tools, particularly ChatGPT, may serve as useful adjuncts for carbohydrate counting for people with type 1 diabetes, supporting self-management. CI - (c) 2026 The Author(s). Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd. FAU - Zagaroli, Luca AU - Zagaroli L AUID- ORCID: 0000-0003-0202-9547 AD - Unit of Pediatrics, San Salvatore Hospital, L'Aquila, Italy. FAU - Caione, Nicholas AU - Caione N AUID- ORCID: 0009-0009-4695-4348 AD - Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy. FAU - Zara, Sabina AU - Zara S AD - Dietetics Service, San Salvatore Hospital, L'Aquila, Italy. FAU - Guerra, Federica AU - Guerra F AUID- ORCID: 0009-0003-0950-8935 AD - Unit of Pediatrics, San Salvatore Hospital, L'Aquila, Italy. FAU - Zugaro, Antonella AU - Zugaro A AD - Diabetes Unit, San Salvatore Hospital, L'Aquila, Italy. FAU - Baroni, Marco Giorgio AU - Baroni MG AUID- ORCID: 0000-0002-3224-6078 AD - Department of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy. AD - IRCCS Neuromed, Pozzilli (IS), Italy. FAU - Iezzi, Maria Laura AU - Iezzi ML AUID- ORCID: 0000-0003-4089-7273 AD - Unit of Pediatrics, San Salvatore Hospital, L'Aquila, Italy. FAU - Delvecchio, Maurizio AU - Delvecchio M AUID- ORCID: 0000-0002-1528-0012 AD - Department of Biotechnological and Applied Clinical Sciences, University of L'Aquila, L'Aquila, Italy. LA - eng PT - Journal Article DEP - 20260413 PL - England TA - Diabetes Obes Metab JT - Diabetes, obesity & metabolism JID - 100883645 RN - 0 (Dietary Carbohydrates) SB - IM MH - Humans MH - *Artificial Intelligence MH - *Diabetes Mellitus, Type 1/diet therapy MH - *Dietary Carbohydrates/analysis/administration & dosage MH - Generative Artificial Intelligence MH - Meals MH - Reproducibility of Results PMC - PMC13243987 OTO - NOTNLM OT - ChatGPT OT - Claude OT - DeepSeek OT - Gemini OT - artificial intelligence OT - carbohydrate counting OT - education OT - nutrition OT - type 1 diabetes COIS- The authors declare no conflicts of interest. EDAT- 2026/04/13 06:32 MHDA- 2026/06/11 12:41 PMCR- 2026/06/08 CRDT- 2026/04/13 05:43 PHST- 2026/03/28 00:00 [revised] PHST- 2026/02/03 00:00 [received] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/06/11 12:41 [medline] PHST- 2026/04/13 06:32 [pubmed] PHST- 2026/04/13 05:43 [entrez] PHST- 2026/06/08 00:00 [pmc-release] AID - DOM70747 [pii] AID - 10.1111/dom.70747 [doi] PST - ppublish SO - Diabetes Obes Metab. 2026 Jul;28(7):5627-5636. doi: 10.1111/dom.70747. Epub 2026 Apr 13. PMID- 41966455 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260918 IS - 1530-891X (Print) IS - 1530-891X (Linking) VI - 32 IP - 9 DP - 2026 Sep TI - Thyroid Function and Non-alcoholic Fatty Liver Disease in Children and Adolescent With Obesity: A Systematic Review and Meta-Analysis. PG - 1422-1429 LID - S1530-891X(26)00935-3 [pii] LID - 10.1016/j.eprac.2026.04.002 [doi] AB - OBJECTIVE: The relationship between thyroid function and non-alcoholic fatty liver disease (NAFLD) in pediatric obesity remains incompletely defined. This systematic review and meta-analysis aimed to quantitatively assess the association between thyroid function parameters and NAFLD in children and adolescents with obesity. METHODS: A systematic search of PubMed/MEDLINE, Scopus, and Web of Science was conducted through December 31, 2025. Observational studies evaluating thyroid function in children and adolescents with obesity, stratified by the presence or absence of NAFLD, were included. Hepatic steatosis was diagnosed using imaging, histology, or validated noninvasive scores. Random-effects meta-analyses were performed to compare serum thyroid-stimulating hormone (TSH), free thyroxine, and free triiodothyronine levels between groups. Study quality was assessed using Quality Assessment of Diagnostic Accuracy Studies version 2. RESULTS: Ten studies encompassing 5145 participants were included. Meta-analysis of 6 studies (n= 3076) demonstrated significantly higher TSH levels in patients with NAFLD compared with controls without NAFLD (mean difference 0.37 mIU/L; 95% confidence interval [CI] 0.07-0.66), with moderate heterogeneity (I(2)= 48.7%). No significant differences were observed for free thyroxine (standardized mean difference -0.35; 95% CI -1.15 to 0.45) or free triiodothyronine (standardized mean difference 0.35; 95% CI -0.26 to 0.96). Sensitivity analyses confirmed the robustness of the TSH association. CONCLUSION: In pediatric obesity, NAFLD is associated with higher TSH levels in the absence of significant changes in circulating thyroid hormone concentrations. These findings suggest that hyperthyrotropinaemia may represent a metabolic marker of hepatic steatosis rather than an adaptive physiological response. Prospective studies are needed to clarify causality and clinical implications. CI - Copyright (c) 2026 AACE. Published by Elsevier Inc. All rights reserved. FAU - Gatta, Elisa AU - Gatta E AD - Department of Clinical and Experimental Sciences, SSD Endocrinologia, University of Brescia, ASST Spedali Civili, Brescia, Italy; Centro per la Diagnosi e Cura delle Neoplasie Endocrine e delle Malattie della Tiroide, University of Brescia, Brescia, Italy. FAU - Ugoccioni, Massimiliano AU - Ugoccioni M AD - Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy. FAU - Gandossi, Elena AU - Gandossi E AD - Department of Clinical and Experimental Sciences, SSD Endocrinologia, University of Brescia, ASST Spedali Civili, Brescia, Italy; Centro per la Diagnosi e Cura delle Neoplasie Endocrine e delle Malattie della Tiroide, University of Brescia, Brescia, Italy. FAU - Delbarba, Andrea AU - Delbarba A AD - Department of Clinical and Experimental Sciences, SSD Endocrinologia, University of Brescia, ASST Spedali Civili, Brescia, Italy. FAU - Agosti, Barbara AU - Agosti B AD - SSD Diabetologia, ASST Franciacorta, Chiari, Italy. FAU - Pirola, Ilenia AU - Pirola I AD - Department of Clinical and Experimental Sciences, SSD Endocrinologia, University of Brescia, ASST Spedali Civili, Brescia, Italy; Centro per la Diagnosi e Cura delle Neoplasie Endocrine e delle Malattie della Tiroide, University of Brescia, Brescia, Italy. FAU - Rotondi, Mario AU - Rotondi M AD - Department of Internal Medicine and Therapeutics, University of Pavia, Pavia, Italy; Istituti Clinici Scientifici Maugeri IRCCS, Unit of Endocrinology and Metabolism, Laboratory for Endocrine Disruptors, Pavia, Italy. FAU - Cappelli, Carlo AU - Cappelli C AD - Department of Clinical and Experimental Sciences, SSD Endocrinologia, University of Brescia, ASST Spedali Civili, Brescia, Italy; Centro per la Diagnosi e Cura delle Neoplasie Endocrine e delle Malattie della Tiroide, University of Brescia, Brescia, Italy. Electronic address: carlo.cappelli@unibs.it. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260409 PL - United States TA - Endocr Pract JT - Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists JID - 9607439 RN - 9002-71-5 (Thyrotropin) RN - 06LU7C9H1V (Triiodothyronine) SB - IM MH - Humans MH - *Non-alcoholic Fatty Liver Disease/epidemiology/physiopathology/blood/etiology MH - Adolescent MH - Child MH - *Thyroid Gland/physiopathology MH - *Pediatric Obesity/complications/physiopathology/epidemiology/blood MH - Thyrotropin/blood MH - Thyroid Function Tests MH - Triiodothyronine/blood OTO - NOTNLM OT - NAFLD OT - hepatic steatosis OT - obesity OT - thyroid COIS- Disclosure The authors have no conflicts of interest to disclose. EDAT- 2026/04/12 12:33 MHDA- 2026/09/01 23:34 CRDT- 2026/04/12 10:30 PHST- 2026/02/08 00:00 [received] PHST- 2026/03/23 00:00 [revised] PHST- 2026/04/02 00:00 [accepted] PHST- 2026/09/01 23:34 [medline] PHST- 2026/04/12 12:33 [pubmed] PHST- 2026/04/12 10:30 [entrez] AID - S1530-891X(26)00935-3 [pii] AID - 10.1016/j.eprac.2026.04.002 [doi] PST - ppublish SO - Endocr Pract. 2026 Sep;32(9):1422-1429. doi: 10.1016/j.eprac.2026.04.002. Epub 2026 Apr 9. PMID- 41965659 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Apr 11 TI - New growth charts for children and adolescents in Catalonia, Spain: developed from routinely collected data (2013-2019). LID - 10.1186/s12889-026-27263-x [doi] LID - 1650 AB - BACKGROUND: Growth charts are essential for detecting early health conditions in children. This study aims to create up-to-date and region-specific growth charts for children and adolescents using large real-world data from primary care electronic health records (EHR) in Catalonia, Spain. METHODS: We used routinely collected EHR of the Institut Catala de la Salut, the main primary care provider in Catalonia. We included children aged one month to 14 years with a birthweight greater than 2500 gr, and at least one anthropometric measurement registered (2013-2019). Growth references for head circumference, weight, length/height, and body mass index (BMI) were fitted using GAMLSS models. We built our charts with data recorded in 2013, validated them using data from 2014 to 2019 and compared them to WHO and Spanish growth charts. RESULTS: With a total of 876,097 records from 155,950 children, we estimated new growth charts. Our curves were higher in the highest percentile, especially for weight and BMI (starting from 4 years old), compared to the WHO standards and for extreme percentiles compared to outdated national charts but were similar to more recent national curves. Validation analyses showed similar results with differences only seen for extreme weight and BMI percentile curves, older ages and later years. CONCLUSIONS: We created new growth charts using a novel approach, accurately representing local growth patterns in the population living in Catalonia. These charts offer primary care professionals a valuable tool for assessing children's and adolescents' growth in the region. CI - (c) 2026. The Author(s). FAU - Mora, Nuria AU - Mora N AD - Primary Care Services Information System (SISAP), Institut Catala de la Salut (ICS), Gran Via de les Corts Catalanes 587, Barcelona, Spain. FAU - Palomar-Cros, Anna AU - Palomar-Cros A AD - Fundacio Institut Universitari per a la recerca a l'Atencio Primaria de Salut Jordi Gol i Gurina (IDIAPJGol), Gran Via de les Corts Catalanes 587, Barcelona, Spain. FAU - Perez-Crespo, Laura AU - Perez-Crespo L AD - Fundacio Institut Universitari per a la recerca a l'Atencio Primaria de Salut Jordi Gol i Gurina (IDIAPJGol), Gran Via de les Corts Catalanes 587, Barcelona, Spain. FAU - Mendez-Boo, Leonardo AU - Mendez-Boo L AD - Primary Care Services Information System (SISAP), Institut Catala de la Salut (ICS), Gran Via de les Corts Catalanes 587, Barcelona, Spain. FAU - Ramos, Francisca AU - Ramos F AD - Primary Care Services Information System (SISAP), Institut Catala de la Salut (ICS), Gran Via de les Corts Catalanes 587, Barcelona, Spain. FAU - Quintana, Manuel AU - Quintana M AD - Primary Care Services Information System (SISAP), Institut Catala de la Salut (ICS), Gran Via de les Corts Catalanes 587, Barcelona, Spain. FAU - Rene, Anna AU - Rene A AD - Primary Care Services Information System (SISAP), Institut Catala de la Salut (ICS), Gran Via de les Corts Catalanes 587, Barcelona, Spain. FAU - Fina, Francesc AU - Fina F AD - Primary Care Services Information System (SISAP), Institut Catala de la Salut (ICS), Gran Via de les Corts Catalanes 587, Barcelona, Spain. FAU - Coma, Ermengol AU - Coma E AD - Primary Care Services Information System (SISAP), Institut Catala de la Salut (ICS), Gran Via de les Corts Catalanes 587, Barcelona, Spain. ecomaredon@gencat.cat. FAU - Duarte-Salles, Talita AU - Duarte-Salles T AD - Fundacio Institut Universitari per a la recerca a l'Atencio Primaria de Salut Jordi Gol i Gurina (IDIAPJGol), Gran Via de les Corts Catalanes 587, Barcelona, Spain. AD - Department of Medical Informatics, Erasmus University Medical Center, Dr. Molewaterplein 40, Rotterdam, The Netherlands. LA - eng PT - Journal Article DEP - 20260411 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Spain MH - *Growth Charts MH - Child, Preschool MH - Child MH - Electronic Health Records MH - Infant MH - Adolescent MH - Female MH - Male MH - Primary Health Care MH - Body Height MH - Body Mass Index MH - Reference Values PMC - PMC13195899 OTO - NOTNLM OT - Childhood OT - Electronic health records OT - Growth curves OT - Primary care COIS- Declarations. Ethics approval and consent to participate: All analysis and methods of this study have been performed in accordance with the Declaration of Helsinki (last update, Fortaleza, Brazil 2013) and existing relevant guidelines and regulations in Spain. This work was approved by the Clinical Research Ethics Committee of IDIAP Jordi Gol with reference number 23/091-P, including a waiver for the informed consent of patients taking part in the study, and the data extracted from the EHR were fully anonymised. There was no patient or public involvement in this study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/12 04:37 MHDA- 2026/05/22 06:36 PMCR- 2026/04/11 CRDT- 2026/04/11 23:17 PHST- 2024/09/12 00:00 [received] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/05/22 06:36 [medline] PHST- 2026/04/12 04:37 [pubmed] PHST- 2026/04/11 23:17 [entrez] PHST- 2026/04/11 00:00 [pmc-release] AID - 10.1186/s12889-026-27263-x [pii] AID - 27263 [pii] AID - 10.1186/s12889-026-27263-x [doi] PST - epublish SO - BMC Public Health. 2026 Apr 11;26(1):1650. doi: 10.1186/s12889-026-27263-x. PMID- 41965597 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Apr 11 TI - Salivary Interleukin-6 and Tumor Necrosis Factor-alpha changes following total oral rehabilitation in children with mild intellectual disability: a prospective interventional study. LID - 10.1186/s12903-026-08230-9 [doi] LID - 813 AB - BACKGROUND: This study aimed to evaluate changes in salivary inflammatory cytokines Interleukin-6 (IL-6) and Tumor Necrosis Factor-alpha (TNF-alpha) in children with mild intellectual disability (ID) and early childhood caries (ECC) following total oral rehabilitation (TOR), and to explore their potential as non-invasive indicators of oral inflammatory status. METHODS: A prospective interventional study was conducted on 23 children aged 3-6 years with mild ID and ECC, recruited from the NITTE Special Child Care Centre and affiliated schools. Unstimulated saliva samples were collected at baseline (pre-TOR), 1 month, and 3 months post-TOR. TOR included comprehensive dental treatment-oral prophylaxis, restorations, pulp therapy, extractions, sealants, and fluoride application-alongside individualised diet counselling and reinforcement of oral hygiene. Salivary IL-6 and TNF-alpha levels were quantified using a high-sensitivity enzyme-linked immunosorbent assay (ELISA). Data were analysed using the Friedman test, followed by Bonferroni-adjusted Wilcoxon signed-rank tests (adjusted alpha = 0.017). RESULTS: The median baseline salivary IL-6 and TNF-alpha levels were 257.97 pg/mL and 173.0 pg/mL, respectively. Both cytokines demonstrated significant reductions at 1 month (IL-6:98.45 pg/mL; TNF-alpha: 77.12 pg/mL) and 3 months (IL-6:98.33 pg/mL; TNF-alpha: 72.0 pg/mL) post-TOR (Friedman test, p < 0.001). Bonferroni-adjusted pairwise comparisons showed significant reductions in IL-6 and TNF-alpha from baseline to 1 month and baseline to 3 months (p < 0.001). The additional reduction in TNF-alpha from 1 to 3 months did not remain statistically significant after adjustment (p = 0.033). CONCLUSION: Total oral rehabilitation was associated with significant reductions in salivary IL-6 and TNF-alpha levels in children with mild intellectual disabilities, consistent with measurable biochemical improvements. These findings support the potential role of salivary cytokines as non-invasive indicators of oral inflammatory changes; however, further controlled studies incorporating clinical correlations and larger cohorts are required before definitive biomarker validation. TRIAL REGISTRATION: The trial was prospectively registered with the Clinical Trials Registry - India (CTRI) with registration No: CTRI/2024/07/071143 dated 2024-07-23. FAU - Baksi, Aishani AU - Baksi A AUID- ORCID: 0000-0002-7279-7827 AD - Department of Paediatric and Preventive Dentistry, A B Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Deralakatte, Mangaluru, Karnataka, 575018, India. FAU - Rai, Kavita AU - Rai K AUID- ORCID: 0000-0002-9677-4144 AD - Department of Paediatric and Preventive Dentistry, A B Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Deralakatte, Mangaluru, Karnataka, 575018, India. FAU - Nair, Manju Raman AU - Nair MR AUID- ORCID: 0000-0002-9391-6223 AD - Department of Paediatric and Preventive Dentistry, A B Shetty Memorial Institute of Dental Sciences, NITTE (Deemed to be University), Deralakatte, Mangaluru, Karnataka, 575018, India. drmanjur@nitte.edu.in. FAU - Saha, Swagata AU - Saha S AUID- ORCID: 0000-0002-2343-5977 AD - Department of Pedodontics and Preventive Dentistry, Dr. D Y Patil Dental College & Hospital, Dr. D Y Patil Vidyapeeth (Deemed to be University), Pune, Maharashtra, India. LA - eng SI - ChiCTR/CTRI/2024/07/071143) dated 2024-07-23 PT - Journal Article DEP - 20260411 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 RN - 0 (Tumor Necrosis Factor-alpha) RN - 0 (Interleukin-6) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Tumor Necrosis Factor-alpha/metabolism/analysis MH - *Interleukin-6/analysis/metabolism MH - Child MH - Prospective Studies MH - *Saliva/chemistry MH - Child, Preschool MH - Female MH - Male MH - *Intellectual Disability/rehabilitation MH - *Dental Caries/rehabilitation/therapy MH - *Mouth Rehabilitation MH - Biomarkers PMC - PMC13156845 OTO - NOTNLM OT - Early Childhood Caries OT - IL-6 OT - Intellectual Disability OT - Salivary Biomarkers OT - TNF-alpha OT - Total Oral Rehabilitation COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Institutional Ethics Committee, A B Shetty Memorial Institute of Dental Sciences, NITTE Deemed to be University (Ref: ETHICS/ABSMIDS/435/2024) and the trial was prospectively registered with the Clinical Trials Registry - India (CTRI) (Registration No: CTRI/2024/07/071143) dated 2024-07-23. The study was conducted in accordance with the principles of the Declaration of Helsinki. Written informed consent for participation was obtained from parents or legal guardians, followed by assent from the participating children where cognitively appropriate. Consent for publication: The parents and caregivers of the participants provided written informed consent for the publication of their personal or clinical details along with any identifying images in this study. In addition, assent was obtained from the children, where cognitively appropriate, to ensure adherence to ethical standards in paediatric research. Competing interests: The authors declare no competing interests. EDAT- 2026/04/12 04:37 MHDA- 2026/06/28 04:09 PMCR- 2026/04/11 CRDT- 2026/04/11 23:15 PHST- 2026/01/29 00:00 [received] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/06/28 04:09 [medline] PHST- 2026/04/12 04:37 [pubmed] PHST- 2026/04/11 23:15 [entrez] PHST- 2026/04/11 00:00 [pmc-release] AID - 10.1186/s12903-026-08230-9 [pii] AID - 8230 [pii] AID - 10.1186/s12903-026-08230-9 [doi] PST - epublish SO - BMC Oral Health. 2026 Apr 11;26(1):813. doi: 10.1186/s12903-026-08230-9. PMID- 41965394 OWN - NLM STAT- MEDLINE DCOM- 20260606 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Apr 11 TI - Field dissipation, dietary risk assessment, and soil fate of chlorantraniliprole and abamectin (dual-active formulation) in watermelon under field conditions. LID - 10.1038/s41598-026-46390-4 [doi] LID - 17063 AB - Chlorantraniliprole and abamectin are frequently applied in combination for pest management in cucurbit crops; however, field-based residue data for their joint use on watermelon remain limited. The present study evaluated the dissipation behaviour, soil residues, and dietary exposure implications of a dual-active formulation (chlorantraniliprole 4.3% + abamectin 1.7% SC) applied to watermelon under supervised field conditions. Fruit samples were collected at 0, 1, 3, 5, 7, 10, and 15 days after the final application, and soil samples were collected at harvest. Residue analysis was performed using LC-MS/MS following modified QuEChERS extraction with matrix-matched calibration. The analytical method demonstrated satisfactory performance, with linearity (R(2) >/= 0.995), mean recoveries within 95-109%, and relative standard deviations below 8%, consistent with internationally accepted validation criteria. At the recommended dose, initial fruit residues were 0.081 mg/kg for chlorantraniliprole and 0.125 mg/kg for abamectin (expressed as avermectin B1a equivalents). Residues declined following first-order kinetics, with calculated half-lives of 4.72-5.11 days for chlorantraniliprole and 6.72-7.55 days for abamectin. Both compounds decreased to below their respective limits of quantification (0.03 mg/kg for chlorantraniliprole and 0.01 mg/kg for abamectin) within 7-10 days. No quantifiable residues were detected in soil at harvest. Screening-level dietary risk assessment using conservative Day 0 residue values indicated negligible chronic exposure for chlorantraniliprole (HQ = 0.000041 for adults) and acceptable exposure for abamectin (HQ = 0.125 for adults; 0.375-0.50 for children). Acute exposure assessment for abamectin corresponded to 12.5% of the ARfD. These findings indicate that, under recommended application practices and with adherence to a 10-day pre-harvest interval, consumer exposure remains within acceptable toxicological limits. This study provides integrated residue dissipation and exposure data for chlorantraniliprole-abamectin use in watermelon and contributes evidence relevant to regulatory evaluation and development of crop-specific residue guidelines. CI - (c) 2026. The Author(s). FAU - Deore, Bhaidas AU - Deore B AD - All India Network Project on Pesticide Residues and Contaminants, Department of Entomology, Mahatma Phule Krishi Vidyapeeth, Rahuri, Ahilyanagar, Maharashtra, 413722, India. FAU - Saindane, Yogesh AU - Saindane Y AD - All India Network Project on Pesticide Residues and Contaminants, Department of Entomology, Mahatma Phule Krishi Vidyapeeth, Rahuri, Ahilyanagar, Maharashtra, 413722, India. FAU - Narwade, Durgesh AU - Narwade D AUID- ORCID: 0009-0006-8501-4461 AD - Department of Entomology, Post Graduate Institute, Mahatma Phule Krishi Vidyapeeth, Rahuri, Ahilyanagar, Maharashtra, 413722, India. durgeshnarwade48408@gmail.com. FAU - Aher, Sachin AU - Aher S AD - All India Network Project on Pesticide Residues and Contaminants, Department of Entomology, Mahatma Phule Krishi Vidyapeeth, Rahuri, Ahilyanagar, Maharashtra, 413722, India. FAU - Magar, Kunal AU - Magar K AD - All India Network Project on Pesticide Residues and Contaminants, Department of Entomology, Mahatma Phule Krishi Vidyapeeth, Rahuri, Ahilyanagar, Maharashtra, 413722, India. FAU - Nawale, Jayant AU - Nawale J AD - All India Network Project on Pesticide Residues and Contaminants, Department of Entomology, Mahatma Phule Krishi Vidyapeeth, Rahuri, Ahilyanagar, Maharashtra, 413722, India. FAU - Deore, Suvarna AU - Deore S AD - Department of Horticulture, Mahatma Phule Krishi Vidyapeeth, Rahuri, Ahilyanagar, Maharashtra, 413722, India. FAU - Kadam, Uttam AU - Kadam U AD - Department of Entomology, Mahatma Phule Krishi Vidyapeeth, Rahuri, Ahilyanagar, Maharashtra, 413722, India. FAU - Kharbade, Satappa AU - Kharbade S AD - Department of Entomology, Mahatma Phule Krishi Vidyapeeth, Rahuri, Ahilyanagar, Maharashtra, 413722, India. LA - eng PT - Journal Article DEP - 20260411 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 70288-86-7 (Ivermectin) RN - 5U8924T11H (abamectin) RN - 0 (ortho-Aminobenzoates) RN - 622AK9DH9G (chlorantranilipole) RN - 0 (Soil) RN - 0 (Pesticide Residues) RN - 0 (Insecticides) RN - 0 (Soil Pollutants) SB - IM MH - *Ivermectin/analogs & derivatives/analysis MH - *ortho-Aminobenzoates/analysis MH - *Citrullus/chemistry MH - *Soil/chemistry MH - Risk Assessment MH - *Pesticide Residues/analysis MH - Tandem Mass Spectrometry MH - Dietary Exposure/analysis MH - *Insecticides/analysis MH - Fruit/chemistry MH - Food Contamination/analysis MH - *Soil Pollutants/analysis PMC - PMC13230619 OTO - NOTNLM OT - Abamectin OT - Chlorantraniliprole OT - Dietary risk assessment OT - Dissipation kinetics OT - LC-MS/MS OT - Watermelon COIS- Declarations. Competing interests: The authors declare no competing interests. Consent to participate: Not applicable. Consent for publication: Not applicable. Ethical approval: This work involves field studies on watermelon and analysis of pesticide residues. It does not contain any studies with human participants or vertebrate animals performed by any of the authors. EDAT- 2026/04/12 04:37 MHDA- 2026/06/06 18:43 PMCR- 2026/04/11 CRDT- 2026/04/11 23:05 PHST- 2026/01/02 00:00 [received] PHST- 2026/03/25 00:00 [accepted] PHST- 2026/06/06 18:43 [medline] PHST- 2026/04/12 04:37 [pubmed] PHST- 2026/04/11 23:05 [entrez] PHST- 2026/04/11 00:00 [pmc-release] AID - 10.1038/s41598-026-46390-4 [pii] AID - 46390 [pii] AID - 10.1038/s41598-026-46390-4 [doi] PST - epublish SO - Sci Rep. 2026 Apr 11;16(1):17063. doi: 10.1038/s41598-026-46390-4. PMID- 41964732 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Apr 11 TI - The association between CALLY index and obesity in adolescents: a comparative analysis with traditional inflammatory markers. LID - 10.1007/s40519-026-01844-6 [doi] LID - 52 AB - OBJECTIVE: To investigate the association between the C-reactive protein-Albumin-lymphocyte (CALLY) index and obesity in adolescents, and evaluate its predictive performance compared to traditional inflammatory markers. METHODS: Data from NHANES 2015-2018 were analyzed, including 2188 adolescents aged 12-20 years. The CALLY index was calculated as (albumin x lymphocytes)/CRP. Multivariate weighted logistic regression was used to assess associations with obesity. Receiver Operating Characteristic (ROC) curves and Area Under the Curve (AUC) were computed to evaluate the predictive performance of the CALLY index compared to traditional inflammatory markers (NLR, PLR, SII, SIRI). Survey-weighted logistic regression assessed associations of CALLY with obesity; model fit (Nagelkerke R(2)) and discrimination were evaluated, with sensitivity analyses for model specifications. RESULTS: The CALLY index was inversely associated with obesity (OR = 0.968, 95% CI 0.958-0.977, p < 0.001), with each 1-unit increase reducing obesity odds by 3.20%. This association remained significant after multivariate adjustment and varied by age, race, and physical activity. The standalone AUC of CALLY (0.743) significantly outperformed traditional markers (PLR: 0.515, NLR: 0.546, SII: 0.593, SIRI: 0.598). Combined with covariates, AUC increased to 0.774 (DeLong test p < 0.001). At the cutoff of 15.10, CALLY achieved > 80% sensitivity with a positive likelihood ratio near 2.0. CONCLUSIONS: The CALLY index is a robust and independent predictor of obesity in adolescents, outperforming traditional inflammatory markers. Its integration with traditional covariates further enhances predictive accuracy, suggesting that the CALLY index could be a valuable tool for early screening and intervention in adolescent obesity. CI - (c) 2026. The Author(s). FAU - Li, Yanchao AU - Li Y AD - Department of Pediatrics, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550000, Guizhou, People's Republic of China. AD - Department of Pediatric Rheumatology and Immunology, Guiyang Maternal and Child Health Care Hospital (Guiyang Children's Hospital), Guiyang, 550003, Guizhou, People's Republic of China. FAU - Shao, Xiaoshan AU - Shao X AD - Department of Pediatrics, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550000, Guizhou, People's Republic of China. sxs22@sina.com. AD - Department of Pediatrics, Guiyang First People Hospital, Guiyang, 550002, Guizhou, People's Republic of China. sxs22@sina.com. FAU - Yang, Xiaoyan AU - Yang X AD - Department of Pediatrics, The Affiliated Hospital of Guizhou Medical University, Guiyang, 550000, Guizhou, People's Republic of China. 469389553@qq.com. LA - eng GR - 82260149/the National Natural Science Foundation of China/ GR - 25NSFCP24/the National Natural Science Foundation of China Cultivation Project of Guizhou Medical University/ GR - 2025FYYJ[HX]-001/the Construction Project of the Hospital-level Key Laboratory of Guizhou Medical University/ GR - gyfyrcbz-2025-04/the High-level Innovative Talent Project of Guizhou Provincial Department of Science and Technology/ GR - Qiankehe Basic-ZK[2023]366/the General Program of Basic Research (Natural Science) of Guizhou Provincial Department of Science and Technology/ GR - Qiankehe Basic-XKBFK[2025]023/the Project for Supporting High-level Universities Outside the Province to Assist Discipline Construction in Guizhou Universities/ GR - 2024GZYXKYJJXM0027/the Guizhou Population Health Foundation/ PT - Comparative Study PT - Journal Article DEP - 20260411 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 RN - 9007-41-4 (C-Reactive Protein) RN - 0 (Biomarkers) RN - 0 (Albumins) SB - IM MH - Humans MH - Adolescent MH - *C-Reactive Protein/metabolism/analysis MH - Biomarkers/blood MH - Female MH - Male MH - Child MH - *Inflammation/blood MH - Young Adult MH - *Albumins/metabolism/analysis MH - *Lymphocytes/metabolism MH - ROC Curve MH - *Pediatric Obesity/blood MH - Nutrition Surveys MH - Obesity PMC - PMC13219132 OTO - NOTNLM OT - Adolescent obesity OT - CALLY index OT - Logistic regression OT - NHANES OT - ROC analysis COIS- Declarations. Ethics approval and consent to participate: The survey protocol was approved by the NCHS Research Ethics Review Committee. Written informed consent was obtained from all participants. All methods adhered to the ethical standards outlined in the 1964 Declaration of Helsinki and its subsequent amendments, or comparable ethical standards. Written informed consent was obtained from all participants and/or their parents. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/12 04:33 MHDA- 2026/05/29 15:46 PMCR- 2026/04/11 CRDT- 2026/04/11 11:04 PHST- 2025/11/11 00:00 [received] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/05/29 15:46 [medline] PHST- 2026/04/12 04:33 [pubmed] PHST- 2026/04/11 11:04 [entrez] PHST- 2026/04/11 00:00 [pmc-release] AID - 10.1007/s40519-026-01844-6 [pii] AID - 1844 [pii] AID - 10.1007/s40519-026-01844-6 [doi] PST - epublish SO - Eat Weight Disord. 2026 Apr 11;31(1):52. doi: 10.1007/s40519-026-01844-6. PMID- 41963909 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1476-511X (Electronic) IS - 1476-511X (Linking) VI - 25 IP - 1 DP - 2026 Apr 10 TI - Assessment of BMI percentages of obesity thresholds and cardiometabolic risk factors in children and adolescents: a retrospective cross-sectional study in Beijing. LID - 10.1186/s12944-026-02940-3 [doi] LID - 133 AB - BACKGROUND: The prevalence of pediatric obesity, particularly severe obesity, is rising rapidly in China. Few studies have examined the relationship between body mass index (BMI) expressed as percentages of obesity thresholds (%BMI) and cardiometabolic risks in Chinese pediatric population. This study aims to evaluate the dose-response relationship between %BMI and cardiometabolic risk factors among children and adolescents in Beijing. METHODS: This retrospective cross-sectional study utilized electronic health records (EHRs) of children and adolescents aged 7-18 years with obesity attending a specialized clinic. Anthropometric and laboratory data were extracted and validated. Individuals were categorized into class 1 obesity (BMI 100-120% of the obesity thresholds), class 2 (120-140%), and class 3 (>/= 140%). Logistic regression assessed the associations between obesity subcategories and four cardiometabolic risk factors, including prediabetes, dyslipidemia, insulin resistance (IR), and elevated liver enzymes. Restricted cubic spline (RCS) models were used to investigate the dose-response relationship between %BMI and cardiometabolic risk factors. RESULTS: Among 1,761 included individuals, class 3 obesity was associated with significantly higher odds of prediabetes (OR = 1.49 [95% CI: 1.01-2.19] for boys; OR = 2.91 [95% CI: 1.57-5.41] for girls), IR (OR = 4.40 [95% CI: 2.66-7.51] for boys; OR = 3.52 [95% CI: 1.63-8.35] for girls), and elevated liver enzymes (OR = 2.65 [95% CI: 1.81-3.93] for boys; OR = 2.97 [95% CI: 1.65-5.47] for girls) compared to class 1. Linear dose-response relationships were observed between %BMI and these factors. Dyslipidemia and its components (e.g., low high-density lipoprotein cholesterol and high triglyceride) exhibited complex dose-response relationships that varied by sex and Tanner Stage. CONCLUSIONS: Among obese children and adolescents in Beijing, higher %BMI might be linearly associated with greater likelihood of prediabetes, IR, and elevated liver enzymes, while dyslipidemia exhibits sex- and puberty-specific patterns. Further researches are required to characterize cardiometabolic risks across the obesity spectrum in Chinese pediatric population to inform targeted interventions. FAU - Xiao, Ling AU - Xiao L AD - Clinical Nutrition Center, Capital Center for Children's Health, Capital Medical University, Beijing, 100020, China. FAU - Zeng, Yin AU - Zeng Y AD - Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100020, China. FAU - Zheng, Si AU - Zheng S AD - Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100020, China. FAU - Wang, Xiao-Yan AU - Wang XY AD - Clinical Nutrition Center, Capital Center for Children's Health, Capital Medical University, Beijing, 100020, China. FAU - Guo, Zhen AU - Guo Z AD - Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100020, China. FAU - Cui, Ying AU - Cui Y AD - Capital Center for Children's Health, Capital Medical University, Beijing, 100020, China. FAU - Tang, Rui AU - Tang R AD - Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100020, China. FAU - Guo, Lin-Lin AU - Guo LL AD - Capital Center for Children's Health, Capital Medical University, Beijing, 100020, China. guolinlin@shouer.com.cn. FAU - Li, Jiao AU - Li J AD - Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100020, China. jiao.li@pumc.edu.cn. LA - eng GR - 2023ZD0509701/National Science and Technology Major Project/ GR - 2024YFA1307701/Key Technologies Research and Development Program/ GR - 2021-I2M-1-056/CAMS Innovation Fund for Medical Sciences/ PT - Journal Article DEP - 20260410 PL - England TA - Lipids Health Dis JT - Lipids in health and disease JID - 101147696 SB - IM MH - Humans MH - Child MH - Adolescent MH - Male MH - Female MH - Cross-Sectional Studies MH - Retrospective Studies MH - *Body Mass Index MH - *Cardiometabolic Risk Factors MH - Insulin Resistance MH - *Dyslipidemias/epidemiology/blood MH - Beijing/epidemiology MH - Risk Factors MH - *Prediabetic State/epidemiology/blood MH - *Obesity/epidemiology MH - *Pediatric Obesity/epidemiology/complications/blood MH - *Cardiovascular Diseases/epidemiology PMC - PMC13188306 OTO - NOTNLM OT - Cardiometabolic risk OT - Dyslipidemia OT - Insulin resistance OT - Pediatric OT - Prediabetes OT - Severe obesity COIS- Declarations. Ethics approval and consent to participate: The study is conducted in accordance with the principles outlined in the Declaration of Helsinki. Given the retrospective nature of this study and the anonymous status of the data, the need for written informed consent was waived by the ethics committee of Capital Center for Children's Health, Capital Medical University (No. SHERLLM2024044). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/11 00:32 MHDA- 2026/06/27 12:36 PMCR- 2026/04/10 CRDT- 2026/04/10 23:50 PHST- 2026/01/22 00:00 [received] PHST- 2026/03/28 00:00 [accepted] PHST- 2026/06/27 12:36 [medline] PHST- 2026/04/11 00:32 [pubmed] PHST- 2026/04/10 23:50 [entrez] PHST- 2026/04/10 00:00 [pmc-release] AID - 10.1186/s12944-026-02940-3 [pii] AID - 2940 [pii] AID - 10.1186/s12944-026-02940-3 [doi] PST - epublish SO - Lipids Health Dis. 2026 Apr 10;25(1):133. doi: 10.1186/s12944-026-02940-3. PMID- 41963694 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20261008 IS - 1179-1942 (Electronic) IS - 0114-5916 (Linking) VI - 49 IP - 9 DP - 2026 Sep TI - Reliability of Self-Reported Maternal Health and Mother-Infant Outcome Data in Web-Based Questionnaires. PG - 1069-1084 LID - 10.1007/s40264-026-01671-9 [doi] AB - OBJECTIVES: The BELpREG registry in Belgium collects self-reported real-world data on perinatal medication use and mother-infant outcomes. Given the importance of self-reported data for pregnancy safety studies, this study aims to assess the reliability of maternal health and mother-infant outcome data reported in BELpREG. METHODS: We compared self-reported maternal health and mother-infant outcomes in the BELpREG registry with medical record data from gynaecologists, general practitioners, and midwives. Participants included pregnant women enrolled in BELpREG, aged 18 years or older, who delivered between November 2022 and April 2024 and had medical record data provided by at least one healthcare professional (HCP). Comparisons for continuous variables such as pre-pregnancy body mass index (BMI), gestational age at delivery, and infant metrics at birth were analysed using intraclass correlation coefficients (ICCs). For dichotomous and categorical variables, including pregnancy complications, delivery characteristics, and hospital admissions, we used Cohen's Kappa and observed proportions of positive and negative agreement. RESULTS: This study included 175 participants with available medical record data. Medical records were mostly returned by gynaecologists (40%) and midwives (25.7%). Reliability was high for pregnancy complications, onset, and mode of delivery. Gestational age showed almost perfect concordance (ICC 0.99). Infant outcomes, including birth metrics and Apgar scores, were highly reliable (ICC > 0.90), with almost perfect categorisation into birth weight percentiles (Cohen's Kappa 0.97). Self-reported maternal BMI exhibited moderate reliability as a continuous measure (ICC 0.75), but almost perfect agreement when categorised (Cohen's Kappa 0.89). The low prevalence of hospital admissions, delivery complications, infant complications, postpartum complications, and birth defects limited the assessment of these outcomes. CONCLUSIONS: The BELpREG registry demonstrated high agreement between self-reported and HCP-reported data for most maternal health and mother-infant outcomes, supporting its use in future pregnancy safety studies. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Switzerland AG. FAU - Sillis, Laure AU - Sillis L AUID- ORCID: 0000-0002-7545-2357 AD - Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. laure.sillis@kuleuven.be. AD - Research Foundation Flanders (FWO), Brussels, Belgium. laure.sillis@kuleuven.be. AD - L-C&Y-KU Leuven Child and Youth Institute, Leuven, Belgium. laure.sillis@kuleuven.be. FAU - Van Mechelen, Laura AU - Van Mechelen L AD - Faculty of Pharmaceutical Sciences, KU Leuven, Leuven, Belgium. FAU - van Gelder, Marleen M H J AU - van Gelder MMHJ AUID- ORCID: 0000-0003-4853-4434 AD - IQ Health Science Department, Radboud University Medical Centre, Nijmegen, The Netherlands. FAU - Lenie, Sien AU - Lenie S AUID- ORCID: 0009-0000-8786-4765 AD - Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. AD - L-C&Y-KU Leuven Child and Youth Institute, Leuven, Belgium. FAU - Allegaert, Karel AU - Allegaert K AUID- ORCID: 0000-0001-9921-5105 AD - Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. AD - L-C&Y-KU Leuven Child and Youth Institute, Leuven, Belgium. AD - Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Department of Clinical Pharmacy, Erasmus MC Sophia's Children Hospital, Rotterdam, The Netherlands. FAU - Bogaerts, Annick AU - Bogaerts A AUID- ORCID: 0000-0003-2718-4682 AD - L-C&Y-KU Leuven Child and Youth Institute, Leuven, Belgium. AD - Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Faculty of Health, University of Plymouth, Devon, UK. FAU - De Vos, Maarten AU - De Vos M AUID- ORCID: 0000-0002-3482-5145 AD - Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Department of Electrical Engineering (ESAT), KU Leuven, Leuven, Belgium. FAU - Hompes, Titia AU - Hompes T AUID- ORCID: 0000-0002-6206-0389 AD - Adult Psychiatry UPC, KU Leuven, Leuven, Belgium. AD - Department of Neurosciences, KU Leuven, Leuven, Belgium. FAU - Smits, Anne AU - Smits A AUID- ORCID: 0000-0002-0710-6698 AD - L-C&Y-KU Leuven Child and Youth Institute, Leuven, Belgium. AD - Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Neonatal Intensive Care Unit, University Hospitals Leuven, Leuven, Belgium. FAU - Van Calsteren, Kristel AU - Van Calsteren K AUID- ORCID: 0000-0002-2438-6783 AD - Department of Development and Regeneration, KU Leuven, Leuven, Belgium. AD - Department of Obstetrics and Gynaecology, University Hospitals Leuven, Leuven, Belgium. FAU - Verbakel, Jan Y AU - Verbakel JY AUID- ORCID: 0000-0002-7166-7211 AD - Department of Public Health and Primary Care, KU Leuven, Leuven, Belgium. AD - Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK. FAU - Foulon, Veerle AU - Foulon V AUID- ORCID: 0000-0002-4053-3915 AD - Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. AD - L-C&Y-KU Leuven Child and Youth Institute, Leuven, Belgium. FAU - Ceulemans, Michael AU - Ceulemans M AUID- ORCID: 0000-0002-4130-5869 AD - Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium. AD - Research Foundation Flanders (FWO), Brussels, Belgium. AD - L-C&Y-KU Leuven Child and Youth Institute, Leuven, Belgium. AD - IQ Health Science Department, Radboud University Medical Centre, Nijmegen, The Netherlands. LA - eng PT - Journal Article DEP - 20260410 PL - New Zealand TA - Drug Saf JT - Drug safety JID - 9002928 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Self Report/standards MH - Adult MH - Reproducibility of Results MH - *Pregnancy Outcome/epidemiology MH - Belgium/epidemiology MH - *Maternal Health/statistics & numerical data MH - Registries MH - Surveys and Questionnaires MH - Infant, Newborn MH - Pregnancy Complications/epidemiology MH - Internet MH - Young Adult MH - Gestational Age MH - Medical Records COIS- Declarations. Author contributions: Laure Sillis: Conceptualisation, data curation, formal analysis, funding acquisition, investigation, methodology, project administration, software, validation, visualisation, and writing - original draft. Laura Van Mechelen: Formal analysis, investigation, methodology, project administration, and writing - review and editing. Marleen M.H.J. van Gelder: Conceptualisation, methodology, and writing - review and editing. Sien Lenie: Investigation, project administration, validation, and writing - review and editing. Karel Allegaert: Methodology and writing - review and editing. Annick Bogaerts: Methodology and writing - review and editing. Maarten De Vos: Methodology and writing - review and editing. Titia Hompes: Methodology and writing - review and editing. Anne Smits: Methodology and writing - review and editing. Kristel Van Calsteren: Methodology and writing - review and editing. Jan Y Verbakel: Methodology and writing - review and editing. Veerle Foulon: Conceptualisation, funding acquisition, methodology, project administration, resources, supervision, and writing - review and editing. Michael Ceulemans: Conceptualisation, funding acquisition, investigation, methodology, project administration, resources, supervision, and writing - review and editing. All authors read and approved the final version. Conflict of interest: The authors declare no conflicts of interest. The companies providing research grants for the BELpREG initiative had no role in the design of BELpREG or this reliability study; nor in the collection, analysis, or interpretation of data; the writing of the manuscript; or the decision to publish the results. Data sharing: The data used for this analysis were collected under participants' informed consent for uses as directed by the study principal investigator and are not available for public access due to ethical and privacy reasons. Requests for use of the data should be directed to the corresponding author. Code availability: Statistical analyses were performed using R software. Requests for use of the code should be directed to the corresponding author. Ethics approval: Ethics approval for this study was obtained from the Ethics Committee Research UZ/KU Leuven (S66464). Consent to participate: All BELpREG participants provided electronic informed consent. Consent for publication: Not applicable. No individual participant data are presented in this article in a way that would allow identification of individual participants. Additional Contributions: The authors express their gratitude to the BELpREG participants and healthcare professionals who provided data for this study. Special thanks to Linda Lukeba for her pivotal role in data collection from healthcare professionals. The authors also appreciate the technical support from Digile for the BELpREG registry and the assistance from Medipim in upgrading the BELpREG questionnaires. Disclaimer: The terms 'individuals', 'participants', 'women', 'woman', 'mother', and 'maternal' are used in this article to refer to all those who are pregnant and give birth. The authors acknowledge that not all people who are pregnant and give birth will identify themselves as women. EDAT- 2026/04/11 00:32 MHDA- 2026/08/21 17:37 CRDT- 2026/04/10 23:29 PHST- 2025/04/08 00:00 [received] PHST- 2026/03/18 00:00 [accepted] PHST- 2026/08/21 17:37 [medline] PHST- 2026/04/11 00:32 [pubmed] PHST- 2026/04/10 23:29 [entrez] AID - 10.1007/s40264-026-01671-9 [pii] AID - 10.1007/s40264-026-01671-9 [doi] PST - ppublish SO - Drug Saf. 2026 Sep;49(9):1069-1084. doi: 10.1007/s40264-026-01671-9. Epub 2026 Apr 10. PMID- 41961782 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260410 LR - 20260813 IS - 2767-3375 (Electronic) IS - 2767-3375 (Linking) VI - 6 IP - 4 DP - 2026 TI - Predicting the burden of acute malnutrition in drought-prone regions of Kenya: A statistical analysis. PG - e0004485 LID - 10.1371/journal.pgph.0004485 [doi] LID - e0004485 AB - In drought-prone regions, timely and granular predictions of the burden of acute malnutrition could support decision-making. We explored whether routinely collected and/or publicly available data could be used to predict the prevalence of global and severe acute malnutrition, as well as the mean weight-for-height Z-score and middle-upper-arm circumference for age Z-score, in arid- and semi-arid regions of Kenya, where drought is projected to increase in frequency and intensity. The study covered six counties of northern Kenya and the period 2015-2019, during which a major drought occurred. To validate models, we sourced and curated so-called SMART anthropometric surveys covering one or more sub-counties for a total of 79 explicit survey strata and 44,218 individual child observations. We associated these surveys' predictors specified at the sub-county or county level, and comprising climate food security, observed malnutrition, epidemic disease incidence, health service utilisation and other social conditions. We explored both generalised linear or additive models and random forests and quantified their out-of-sample performance using cross-validation. In most counties, survey-estimated nutritional indicators were worst during the October 2016-December 2019 drought period; the drought also saw peaks in insecurity and steep vaccination declines. Candidate models had moderate performance, with random forests slightly outperforming generalised linear models. The most promising performance was observed for global acute malnutrition prevalence. The study did not identify a model that could very accurately predict malnutrition burden, but analyses relying on larger datasets with a wider range of predictors and encompassing multiple drought periods may yield sufficient performance and are warranted given the potential utility and efficiency of predictive models in lieu of assumptions or expensive and untimely ground data collection. CI - Copyright: (c) 2026 Checchi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Checchi, Francesco AU - Checchi F AUID- ORCID: 0000-0001-9030-5382 AD - Department of Infectious Disease Epidemiology and International Health, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom. FAU - AbuKoura, Rahaf AU - AbuKoura R AUID- ORCID: 0000-0002-1956-2551 AD - Department of Infectious Disease Epidemiology and International Health, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom. FAU - Kadiyala, Suneetha AU - Kadiyala S AD - Department of Population Health, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom. FAU - Nyawo, Mara AU - Nyawo M AUID- ORCID: 0000-0001-8011-9914 AD - United Nations Children's Fund, East and Southern Africa Regional Office, Nairobi, Kenya. FAU - Maina, Lucy AU - Maina L AD - United Nations Children's Fund, Kenya Country Office, Nairobi, Kenya. LA - eng PT - Journal Article DEP - 20260410 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC13068232 COIS- The authors have declared that no competing interests exist. EDAT- 2026/04/10 18:32 MHDA- 2026/04/10 18:33 PMCR- 2026/04/10 CRDT- 2026/04/10 13:33 PHST- 2025/03/21 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/04/10 18:33 [medline] PHST- 2026/04/10 18:32 [pubmed] PHST- 2026/04/10 13:33 [entrez] PHST- 2026/04/10 00:00 [pmc-release] AID - PGPH-D-25-00663 [pii] AID - 10.1371/journal.pgph.0004485 [doi] PST - epublish SO - PLOS Glob Public Health. 2026 Apr 10;6(4):e0004485. doi: 10.1371/journal.pgph.0004485. eCollection 2026. PMID- 41961463 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20260919 IS - 2731-5541 (Electronic) IS - 2731-5533 (Print) IS - 2731-5533 (Linking) VI - 47 IP - 5 DP - 2026 Oct TI - Implementation and Feasibility of a Co-designed Intervention to Promote Healthy Eating: Designed by Children for Children. PG - 921-937 LID - 10.1007/s10935-026-00913-x [doi] AB - The development of healthy dietary behaviours during childhood is crucial for long-term health, and schools represent a key setting for health promotion. Actively involving children in health-related projects offers a meaningful opportunity to encourage and reinforce healthy behaviours. Therefore, this formative pilot study primarily aimed to explore the feasibility, acceptability, and engagement potential of a participatory, school-based dietary intervention involving preadolescent students. During the 2023/24 school year, a participatory research project including a formative pilot study was conducted at a school in Bremen, Germany, aiming to involve children in the co-design, implementation, and formal evaluation of a school-based dietary intervention. Sixth-grade students (11-12 years old) collaborated with researchers over several months to design an intervention for their 5th -grade peers (10-12 years old). The intervention included the free distribution of self-prepared healthy snacks and the display of educational posters. Implementation experiences and participant responses were explored using a child-friendly food neophobia questionnaire, measuring children's reluctance to try unfamiliar foods, alongside narrative methods. Participation in this pilot study was perceived as highly positive by 6th -grade students, who showed increased confidence, self-esteem, and interest as well as skills in nutrition and cooking/baking. The collaborative process fostered strong relationships between students and researchers and supported sutdents' sense of empowerment. Although 5th -grade students generally enjoyed the free snacks, their food neophobia scores showed no significant change, consistent with the formative nature of the study. Overall, the findings highlight the feasibility and acceptability of participatory approaches to school-based nutrition interventions and underscore their potential to promote engagement and empowerment among children. Our results provide valuable insights into participatory development and implementation processes to inform future school-based health promotion efforts. CI - (c) 2026. The Author(s). FAU - Klink, Urte AU - Klink U AD - Department for Health Services Research, Institute for Public Health and Nursing Research, University Bremen, Universitaetsallee 1c, D-28359, Bremen, Germany. FAU - Jilani, Hannah AU - Jilani H AUID- ORCID: 0000-0001-5799-8383 AD - Department for Health Services Research, Institute for Public Health and Nursing Research, University Bremen, Universitaetsallee 1c, D-28359, Bremen, Germany. jilani@uni-bremen.de. LA - eng PT - Journal Article DEP - 20260410 PL - Switzerland TA - J Prev (2022) JT - Journal of prevention (2022) JID - 9918351283506676 SB - IM MH - Humans MH - Child MH - *Health Promotion/methods MH - Male MH - Pilot Projects MH - *Diet, Healthy MH - Female MH - Feasibility Studies MH - Germany MH - Surveys and Questionnaires MH - Schools MH - School Health Services PMC - PMC13582117 OTO - NOTNLM OT - Adolescent OT - Child OT - Community-based participatory research OT - Diet OT - Empowerment OT - Health behaviour COIS- Declarations. Conflict of Interest: None declared. Ethical Approval: The institutional review board of the University of Bremen gave ethical approval. Parents or legal guardians provided informed consent for children; children provided assent. Parent consent forms were provided in class for children to give to their parents or legal guardians. EDAT- 2026/04/10 13:00 MHDA- 2026/09/16 17:36 PMCR- 2026/04/10 CRDT- 2026/04/10 11:19 PHST- 2025/05/18 00:00 [received] PHST- 2026/03/26 00:00 [accepted] PHST- 2026/09/16 17:36 [medline] PHST- 2026/04/10 13:00 [pubmed] PHST- 2026/04/10 11:19 [entrez] PHST- 2026/04/10 00:00 [pmc-release] AID - 10.1007/s10935-026-00913-x [pii] AID - 913 [pii] AID - 10.1007/s10935-026-00913-x [doi] PST - ppublish SO - J Prev (2022). 2026 Oct;47(5):921-937. doi: 10.1007/s10935-026-00913-x. Epub 2026 Apr 10. PMID- 41961325 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260921 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 5 DP - 2026 Apr 10 TI - Efficacy of physiotherapeutic interventions in the management of functional constipation in pediatric and adolescent populations: a systematic review and meta-analysis. LID - 10.1007/s00431-026-06831-8 [doi] LID - 251 AB - To evaluate the efficacy of physiotherapeutic interventions in the management of functional constipation (FC) in pediatric and adolescent populations, and to analyze the methodological quality of the available evidence. A systematic review of randomized controlled trials (RCTs) published in PubMed, Cochrane Library, Embase, and Web of Science was conducted (February-March 2025). Studies including participants aged 18 years diagnosed with FC, treated with pelvic floor physiotherapy versus conventional medical treatment, were included. Methodological quality was assessed using the PEDro scale (Physiotherapy Evidence Database). Seven clinical trials were included in the meta-analysis with sample sizes ranging from 45 to 400 participants (total n = 775). The interventions covered pelvic floor exercises, biofeedback, telerehabilitation, visceral mobilization, and electrostimulation. The majority showed improvements in painful defecation, fecal consistency, and quality of life, with less consistent results in defecatory frequency (MD = 1.00; 95% CI: 0.35 to 1.65). However, the marked heterogeneity in protocols (type, intensity, duration), variability in assessment instruments, and frequent co-intervention with polyethylene glycol (PEG) hinder comparison between studies and limit external validity. Follow-ups shorter than 12 months and the absence of blinding of participants and therapists constitute additional risks of bias. CONCLUSIONS: Pelvic floor physiotherapy appears to be a promising adjuvant intervention in the treatment of pediatric FC, with positive effects on symptoms and quality of life. Nevertheless, multicenter trials with standardized protocols, large samples, and prolonged follow-up are required to confirm its efficacy and long-term sustainability. WHAT IS KNOWN: *Despite the clinical use of physiotherapy, there was no quantitative synthesis integrating its efficacy against standard medical treatment, nor had its specific effect size on defecatory pain and quality of life been established in the pediatric population. WHAT IS NEW: *This meta-analysis confi rms that pelvic fl oor physiotherapy is an eff ective adjuvant with a large effect size, demonstrating consistent improvements in reducing painful defecation and enhancing the biopsychosocial dimensions of quality of life. CI - (c) 2026. The Author(s). FAU - Medrano-Sanchez, Esther M AU - Medrano-Sanchez EM AUID- ORCID: 0000-0003-4279-5852 AD - Departamento de Fisioterapia, Universidad de Sevilla, Calle Avenzoar, 9, 41009, Sevilla, Spain. emedrano@us.es. FAU - Diaz-Gutierrez, Marta AU - Diaz-Gutierrez M AD - Physiotherapist, Medical Center Ruben Garcia, Sevilla, Spain. FAU - Garcia-Polo, Paula AU - Garcia-Polo P AD - Physiotherapist, Zaidafisiopelvic, Sevilla, Spain. FAU - Diaz-Mohedo, Esther AU - Diaz-Mohedo E AD - Departamento de Fisioterapia, Universidad de Malaga, Avda. de Cervantes, 2, 29016, Malaga, Spain. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260410 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Constipation/therapy MH - Child MH - Adolescent MH - *Physical Therapy Modalities MH - Pelvic Floor/physiopathology MH - Treatment Outcome MH - Randomized Controlled Trials as Topic MH - Quality of Life MH - Exercise Therapy/methods PMC - PMC13068696 OTO - NOTNLM OT - Functional constipation OT - Pediatrics OT - Pelvic floor OT - Physiotherapy COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/04/10 13:01 MHDA- 2026/04/10 13:02 PMCR- 2026/04/10 CRDT- 2026/04/10 11:15 PHST- 2025/12/04 00:00 [received] PHST- 2026/02/27 00:00 [accepted] PHST- 2025/12/18 00:00 [revised] PHST- 2026/04/10 13:02 [medline] PHST- 2026/04/10 13:01 [pubmed] PHST- 2026/04/10 11:15 [entrez] PHST- 2026/04/10 00:00 [pmc-release] AID - 10.1007/s00431-026-06831-8 [pii] AID - 6831 [pii] AID - 10.1007/s00431-026-06831-8 [doi] PST - epublish SO - Eur J Pediatr. 2026 Apr 10;185(5):251. doi: 10.1007/s00431-026-06831-8. PMID- 41961213 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260921 IS - 1473-4230 (Electronic) IS - 1473-4222 (Print) IS - 1473-4222 (Linking) VI - 25 IP - 2 DP - 2026 Apr 10 TI - Sleep During NICU Care Is Associated With Proportional Cerebellar Size at Term-Equivalent Age in Extrem Infantsmely Preter. LID - 10.1007/s12311-026-01988-2 [doi] LID - 49 AB - BACKGROUND: Infants born extremely preterm (< 28 weeks' gestation) are born during a phase of rapid cerebellar growth, when disturbances in brain maturation are common and reduced cerebellar size has been linked to unfavorable neurodevelopment. During late gestation, sleep is the dominant brain state and provides structured endogenous activity supporting circuit formation. In the neonatal intensive care unit (NICU), sleep may become fragmented at a developmental stage when the cerebellum is particularly vulnerable. We hypothesized that sleep quantity during late NICU care is associated with proportional cerebellar size at term-equivalent age (TEA). METHODS: In a retrospective cohort of extremely preterm infants, continuous cardiorespiratory signals recorded at approximately 29-32 weeks postmenstrual age were analyzed using a validated algorithm to quantify sleep-wake states. All infants underwent 3 T MRI at TEA. The primary outcome was cerebellum-to-total brain volume ratio. Associations were tested using multivariable linear regression adjusted for age at MRI, birthweight, duration of mechanical ventilation, and sex. RESULTS: Seventy-one infants contributed multi-day sleep recordings and TEA MRI. Higher total sleep percentage during late NICU monitoring was associated with a larger cerebellum-to-total brain volume ratio at TEA after adjustment for clinical covariates (p = 0.011). Sleep-state composition was not associated with absolute cerebellar volume, which was primarily related to clinical factors. CONCLUSIONS: Greater total sleep during late NICU care is associated with proportionally larger cerebellar size at term-equivalent age. Further studies are needed to determine whether sleep represents a modifiable factor influencing cerebellar development or a marker of overall physiological stability. FAU - Brouwer, J M AU - Brouwer JM AD - Faculty of Science, University of Amsterdam, Science Park 904, Amsterdam, 1098 XH, The Netherlands. AD - Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, Utrecht, 3584 EA, The Netherlands. FAU - Bakker, A M AU - Bakker AM AD - Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, Utrecht, 3584 EA, The Netherlands. AD - Faculty of Medical Sciences, University of Groningen, Antonius Deusinglaan 1, Groningen, 9713 AV, The Netherlands. FAU - de Groot, E AU - de Groot E AD - Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, Utrecht, 3584 EA, The Netherlands. FAU - Tataranno, M L AU - Tataranno ML AD - Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, Utrecht, 3584 EA, The Netherlands. FAU - Benders, M AU - Benders M AD - Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, Utrecht, 3584 EA, The Netherlands. FAU - Dudink, J AU - Dudink J AD - Department of Neonatology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Lundlaan 6, Utrecht, 3584 EA, The Netherlands. j.dudink@umcutrecht.nl. LA - eng PT - Journal Article DEP - 20260410 PL - United States TA - Cerebellum JT - Cerebellum (London, England) JID - 101089443 SB - IM EIN - Cerebellum. 2026 Apr 30;25(3):65. doi: 10.1007/s12311-026-02010-5. PMID: 42056574 MH - Humans MH - Female MH - Male MH - *Cerebellum/diagnostic imaging/growth & development MH - *Intensive Care Units, Neonatal MH - *Sleep/physiology MH - Infant, Newborn MH - Retrospective Studies MH - Magnetic Resonance Imaging MH - *Infant, Extremely Premature/physiology MH - Gestational Age MH - Organ Size PMC - PMC13068692 OTO - NOTNLM OT - Cerebellum development OT - Neurodevelopmental disorders OT - Premature OT - Sleep COIS- Declarations. Ethical approval: Approval for the study was granted by the Medical Research Ethics Committee (MREC) of the University Medical Centre Utrecht (no. 21‑066‑C). As term‑equivalent age MRI and continuous physiological monitoring are standard components of routine NICU practice, the MREC waived the requirement for written parental consent. Informed consent: Because all procedures were part of routine clinical care and no additional interventions were performed, the need for written parental consent was waived by the MREC. Competing interests: The authors declare no competing interests. Data privacy and confidentiality: To ensure data privacy, all collected information was pseudonymized prior to analysis and handled in accordance with institutional and national data‑protection regulations. EDAT- 2026/04/10 13:01 MHDA- 2026/06/28 06:36 PMCR- 2026/04/10 CRDT- 2026/04/10 11:07 PHST- 2026/01/21 00:00 [received] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/06/28 06:36 [medline] PHST- 2026/04/10 13:01 [pubmed] PHST- 2026/04/10 11:07 [entrez] PHST- 2026/04/10 00:00 [pmc-release] AID - 10.1007/s12311-026-01988-2 [pii] AID - 1988 [pii] AID - 10.1007/s12311-026-01988-2 [doi] PST - epublish SO - Cerebellum. 2026 Apr 10;25(2):49. doi: 10.1007/s12311-026-01988-2. PMID- 41961131 OWN - NLM STAT- Publisher LR - 20260625 IS - 1432-0932 (Electronic) IS - 0940-6719 (Linking) DP - 2026 Apr 10 TI - Finding normo: reporting values for the SRS22r score in healthy sport-active children. LID - 10.1007/s00586-026-09929-7 [doi] AB - INTRODUCTION: Scoliosis Research Society-22 revised (SRS-22r) is a disease-specific measure of quality of life in patients diagnosed with idiopathic scoliosis (AIS). When answering the SRS-22r, patients answer 22 questions with scores 1-5, 1 corresponding to the worst possible option, and 5 to the best. It is validated in children with scoliosis > 10 years. Low SRS-22r scores have been suggested to serve as an indicator for considering surgical intervention along with a progression in Cobb angle. However, there are only few studies on SRS-22r scores among children without spine conditions, making the impact of a spine condition on the health-related quality of life scores in adolescents and teenagers difficult to assess. Since surgical treatment of progressive curves is often performed before age 16, normative data for this age group are essential. The aim therefore was to estimate normative data on children under 16 years of age and to assess what influenced the scores in otherwise healthy children without AIS. METHOD: In total, 264 children, attending a sports-focused public school, were invited to answer the SRS-22r questionnaire and self-reported Tanner stage. 110 children (70 girls) answered the questionnaire, all but one reporting tanner stage as well. All students who received the questionnaire underwent a spine examination performed by a physiotherapist student. RESULTS: The participants had a median age of 12 years [Interquartile range (IQR): 11;14]; most were reporting Tanner stages 3 or 4, although 27.5% of the boys reported stage 5. The median scores of mental health and self-image were 4.0 [IQR: 3.6; 4.4] and 4.2 [IQR: 3.8; 4.4], with boys reporting higher scores in both domains compared to girls. Among all children, the median pain reported was 4.2 [IQR: 3.8;4.6] with no sex difference. The differences between the genders were assessed using the Mann-Whitney U test. Ordinal logistic regression showed that lower pain levels and male sex predicted better mental health and self-image, while higher Tanner stages correlated with poorer outcomes. Interestingly, three boys aged 11 reported Tanner Stage 5, highlighting potential inaccuracies in self-reported data and the need for assisted reporting in body composition questionnaires. CONCLUSION: This study highlights the importance of normative data, revealing that active children without scoliosis report pain and issues with mental health and self-image, when addressed with the SRS-22r. In particular, the SRS-22r scores in this cohort were lower than those found in previous studies of children with scoliosis, highlighting the challenges of interpreting and potentially using the SRS-22r results in a clinical setting. FAU - Damsgaard Hojsager, Frederik AU - Damsgaard Hojsager F AD - Department of Orthopaedic Surgery, Lillebaelt Hospital, Kolding, Denmark. frederik.hojsager@rsyd.dk. FAU - Wedderkopp, Niels AU - Wedderkopp N AD - Clinical Institute, University of Southern Denmark, Odense, Denmark. FAU - Borch, Luise AU - Borch L AD - Department of Pediatric and Adolescent medicine, Godstrup Hospital, Herning, Denmark. AD - NIDO, Godstrup Hospital, Herning, Denmark. FAU - Castelein, Rene AU - Castelein R AD - Department of Orthopedics, University Medical Center Utrecht, Utrecht, Netherlands. FAU - Simony, Ane AU - Simony A AD - Department of Orthopaedic Surgery, Lillebaelt Hospital, Kolding, Denmark. AD - Department of Regional Health Research, University of Southern Denmark, Odense, Denmark. LA - eng PT - Journal Article DEP - 20260410 PL - Germany TA - Eur Spine J JT - European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society JID - 9301980 SB - IM OTO - NOTNLM OT - Back healthy population OT - Cohort specific data OT - Danish public school data OT - Mental health OT - SRS22r COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/04/10 13:00 MHDA- 2026/04/10 13:00 CRDT- 2026/04/10 11:04 PHST- 2025/09/24 00:00 [received] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/03/19 00:00 [revised] PHST- 2026/04/10 13:00 [medline] PHST- 2026/04/10 13:00 [pubmed] PHST- 2026/04/10 11:04 [entrez] AID - 10.1007/s00586-026-09929-7 [pii] AID - 10.1007/s00586-026-09929-7 [doi] PST - aheadofprint SO - Eur Spine J. 2026 Apr 10. doi: 10.1007/s00586-026-09929-7. PMID- 41960961 OWN - NLM STAT- Publisher LR - 20260413 IS - 2737-5935 (Electronic) IS - 0037-5675 (Linking) DP - 2026 Apr 10 TI - Consensus statements on Singapore guidelines for feeding and eating in infants and young children. LID - 10.4103/singaporemedj.SMJ-2025-166 [doi] AB - INTRODUCTION: Optimal nutrition during the first 1000 days of a child's life is crucial for healthy growth and development. Caregiver feeding practices can significantly affect what foods are offered, which foods are preferred and how healthy eating patterns are established, highlighting the need for clear guidance and recommendations. Currently, there are no national guidelines focused on the transition from being fed at birth to independent eating by 2 years old. This study aimed to develop concise, evidence-based recommendations to support healthy eating behaviours in children aged 0-2 years. METHODOLOGY: A systematic literature search was conducted on PubMed, Cumulated Index to Nursing and Allied Health Literature and Excerpta Medica Database to identify relevant articles. The GRADE-ADOLOPMENT methodology was employed to adopt, adapt or develop evidence-based recommendations for feeding and eating practices in infants and young children. This includes using the Evidence-to-Decision framework to ensure recommendations considered the balance of benefits and harms, feasibility and cultural appropriateness. A multidisciplinary panel of domain experts reviewed and refined the recommendations, with consensus defined as >/=70% agreement. A total of 64 articles were reviewed, comprising eight observational cohort studies, 25 randomised controlled trials and 31 systematic reviews (including four meta-analyses). The included studies examined key aspects of complementary feeding: 20 focused on timing, 30 on types of food, 13 on self-regulation and one on the feeding environment. RESULTS: Seven consensus statements were developed based on the evidence and organised into four main domains: Variety, Autonomy, Setting and Timing. All statements achieved unanimous agreement among domain experts. CONCLUSION: These guidelines provide clear, evidence-based recommendations for practical nutrition strategies during early childhood. CI - Copyright (c) 2026 Singapore Medical Journal. FAU - Chan, Daniel AU - Chan D AD - Endocrinology Service, KK Women's and Children's Hospital, Singapore. AD - Duke-NUS Medical School, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. FAU - Ong, Chengsi AU - Ong C AD - Department of Nutrition and Dietetics, KK Women's and Children's Hospital, Singapore. FAU - Loy, See Ling AU - Loy SL AD - Duke-NUS Medical School, Singapore. AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore. FAU - Ku, Chee Wai AU - Ku CW AD - Duke-NUS Medical School, Singapore. AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore. FAU - Lin, Jiaying AU - Lin J AD - Department of Paediatric Medicine, KK Women's and Children's Hospital, Singapore. FAU - Loo, Benny Kai Guo AU - Loo BKG AD - Duke-NUS Medical School, Singapore. AD - Sport and Exercise Medicine Service, KK Women's and Children's Hospital, Singapore. FAU - Tan, Yu Bin AU - Tan YB AD - Duke-NUS Medical School, Singapore. FAU - Tan, Nichole AU - Tan N AD - Duke-NUS Medical School, Singapore. FAU - Ravichandran, Divyapoorani AU - Ravichandran D AD - Department of Paediatric Medicine, KK Women's and Children's Hospital, Singapore. FAU - Tan, Marie AU - Tan M AD - Yong Loo Lin School of Medicine, National University of Singapore, Singapore. FAU - Quah, Phaik Ling AU - Quah PL AD - Duke-NUS Medical School, Singapore. AD - Division of Obstetrics and Gynaecology, KK Women's and Children's Hospital, Singapore. FAU - Lim, Charissa AU - Lim C AD - Health Promotion Board, Singapore. FAU - Pandi, Mythili AU - Pandi M AD - Association for Breastfeeding Advocacy, Singapore. FAU - Leo, Wei Zhi AU - Leo WZ AD - Speech Language Therapy Service, KK Women's and Children's Hospital, Singapore. FAU - Ooi, Pei Ling AU - Ooi PL AD - College of Paediatrics and Child Health, Academy of Medicine, Singapore. FAU - Low, Kah Tzay AU - Low KT AD - College of Paediatrics and Child Health, Academy of Medicine, Singapore. FAU - Han, Wee Meng AU - Han WM AD - Department of Nutrition and Dietetics, KK Women's and Children's Hospital, Singapore. FAU - Chong, Mary Foong-Fong AU - Chong MF AD - Saw Swee Hock School of Public Health, National University of Singapore, Singapore. FAU - Chiou, Fang Kuan AU - Chiou FK AD - Gastroenterology, Hepatology Nutrition Service, KK Women's and Children's Hospital, Singapore. FAU - Chang, Alvin Shang Ming AU - Chang ASM AD - Duke-NUS Medical School, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. AD - Yong Loo Lin School of Medicine, National University of Singapore, Singapore. AD - Department of Neonatology, KK Women's and Children's Hospital, Singapore. AD - Quality, Safety and Risk Management, KK Women's and Children's Hospital, Singapore. FAU - Aw, Marion Margaret AU - Aw MM AD - Yong Loo Lin School of Medicine, National University of Singapore, Singapore. AD - Division of Paediatric Gastroenterology, Nutrition, Hepatology and Liver Transplantation, National University Health System, Singapore. FAU - Rajadurai, Victor Samuel AU - Rajadurai VS AD - Department of Neonatology, KK Women's and Children's Hospital, Singapore. FAU - Tan, Kok Hian AU - Tan KH AD - Duke-NUS Medical School, Singapore. AD - Division of Obstetrics and Gynaecology, KK Women's and Children's Hospital, Singapore. FAU - Yap, Fabian AU - Yap F AD - Endocrinology Service, KK Women's and Children's Hospital, Singapore. AD - Duke-NUS Medical School, Singapore. AD - Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. FAU - Chua, Mei Chien AU - Chua MC AD - Duke-NUS Medical School, Singapore. AD - Department of Neonatology, KK Women's and Children's Hospital, Singapore. LA - eng PT - Journal Article DEP - 20260410 PL - India TA - Singapore Med J JT - Singapore medical journal JID - 0404516 SB - IM OTO - NOTNLM OT - Complementary feeding OT - infants OT - paediatric OT - paediatric food-based dietary guidelines OT - weaning OT - young children EDAT- 2026/04/10 12:59 MHDA- 2026/04/10 12:59 CRDT- 2026/04/10 09:33 PHST- 2025/07/02 00:00 [received] PHST- 2025/11/08 00:00 [accepted] PHST- 2026/04/10 12:59 [pubmed] PHST- 2026/04/10 12:59 [medline] PHST- 2026/04/10 09:33 [entrez] AID - 00077293-990000000-00258 [pii] AID - 10.4103/singaporemedj.SMJ-2025-166 [doi] PST - aheadofprint SO - Singapore Med J. 2026 Apr 10. doi: 10.4103/singaporemedj.SMJ-2025-166. PMID- 41960805 OWN - NLM STAT- MEDLINE DCOM- 20261001 LR - 20261003 IS - 1879-3479 (Electronic) IS - 0020-7292 (Print) IS - 0020-7292 (Linking) VI - 175 IP - 1 DP - 2026 Oct TI - Influence of maternal body mass index on the accuracy of clinical and sonographic fetal weight estimation. PG - 263-272 LID - 10.1002/ijgo.71012 [doi] AB - OBJECTIVE: Estimated fetal weight (EFW) is essential for managing pregnancy and delivery. Currently, two primary methods are used for EFW: Clinical and sonographic estimation. Both might be influenced by maternal habitus. Obesity has become a global epidemic; however, its effect on EFW and the accuracy of the two methods has yet to be determined. The aim of the present study was to describe the accuracy of clinical EFW (cEFW) and sonographic EFW (sEFW) as a function of maternal body mass index (BMI, calculated as weight in kilograms divided by the square of height in meters) by comparing them to actual birth weight. METHODS: This was a retrospective cohort study at a single tertiary center (2014-2020), including term (37-42 weeks) singleton deliveries with documented BMI, cEFW, and sEFW performed within 10 days of delivery, and known birth weight. At our institution, cEFW is routinely performed at admission by trained obstetricians as part of a standardized Leopold-based assessment. Participants were stratified into BMI groups: <25, 25-29.9, 30-34.9, and >/=35. The primary outcome was estimation accuracy across BMI strata, expressed as absolute error (in grams [g]) and as deviations greater than 10% and 20%. Secondary outcomes included diagnostic performance for large-for-gestational-age (LGA) neonates, assessed using receiver operating characteristic (ROC) curves and the area under the curve (AUC). Multivariable logistic regression identified factors associated with an error rate exceeding 20%. RESULTS: Among 19 397 deliveries, 2182 women qualified for analysis. Participants were distributed across BMI groups as follows: <25 (n = 408), 25-29.9 (n = 809), 30-34.9 (n = 634), and >/=35 (n = 331). Mean birth weight rose progressively with BMI, from 3045 +/- 519 g in the lowest BMI group to 3557 +/- 453 g in the >/=35 group (P < 0.01). Across BMI >/=25, cEFW showed larger absolute error than sEFW: BMI 25-29.9 (222 +/- 184 vs. 202 +/- 156 g), 30-34.9 (238 +/- 187 vs. 204 +/- 154 g), and >/=35 (254 +/- 207 vs. 211 +/- 161 g) (all P < 0.01). Rates of sEFW deviation >20% were low and stable across BMI (0.6%-1.7%; P = 0.42), whereas cEFW >20% increased with BMI (2.0%-6.0%; P < 0.01). In adjusted models, cEFW had higher odds of >20% error that escalated with BMI (adjusted odds ratio [aOR] 3.34, 5.87, 9.17 for BMI 25-29.9, 30-34.9, >/=35; all P < 0.01). In adjusted models, maternal BMI was not associated with >20% error in sEFW. For LGA detection, sEFW outperformed cEFW across strata, with the most significant gap at BMI >/=35 (AUC 0.873 vs. 0.791). CONCLUSION: Maternal obesity significantly reduces the accuracy of clinical EFW, whereas sonographic EFW maintains stable performance across BMI strata. Sonographic assessment should therefore be prioritized for fetal weight estimation in women with elevated BMI, particularly in the late third trimester, when weight-based delivery decisions are made. CI - (c) 2026 The Author(s). International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics. FAU - Krencel, Amir AU - Krencel A AUID- ORCID: 0009-0005-7038-6150 AD - Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, Israel. AD - Gray Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Narkis, Bar AU - Narkis B AD - Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, Israel. AD - Gray Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Yedidia Moser, Rotem AU - Yedidia Moser R AD - Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, Israel. AD - Gray Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Bercovich, Or AU - Bercovich O AD - Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, Israel. AD - Gray Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Hendin, Natav AU - Hendin N AD - Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, Israel. AD - Gray Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Romano, Asaf AU - Romano A AD - Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, Israel. AD - Gray Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Hadar, Eran AU - Hadar E AD - Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, Israel. AD - Gray Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Gilboa, Yinon AU - Gilboa Y AD - Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, Israel. AD - Gray Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Houri, Ohad AU - Houri O AD - Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, Israel. AD - Gray Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel. AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain. LA - eng PT - Journal Article DEP - 20260410 PL - United States TA - Int J Gynaecol Obstet JT - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JID - 0210174 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Body Mass Index MH - Retrospective Studies MH - *Fetal Weight MH - *Ultrasonography, Prenatal/methods MH - Adult MH - Birth Weight MH - Obesity/complications MH - ROC Curve MH - Infant, Newborn MH - Gestational Age PMC - PMC13629592 OTO - NOTNLM OT - body mass index OT - fetal weight estimation OT - large-for-gestational-age OT - obesity COIS- The authors report no conflict of interest. EDAT- 2026/04/10 13:00 MHDA- 2026/10/02 03:09 PMCR- 2026/10/01 CRDT- 2026/04/10 08:03 PHST- 2026/03/19 00:00 [revised] PHST- 2026/02/21 00:00 [received] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/10/02 03:09 [medline] PHST- 2026/04/10 13:00 [pubmed] PHST- 2026/04/10 08:03 [entrez] PHST- 2026/10/01 00:00 [pmc-release] AID - IJGO71012 [pii] AID - 10.1002/ijgo.71012 [doi] PST - ppublish SO - Int J Gynaecol Obstet. 2026 Oct;175(1):263-272. doi: 10.1002/ijgo.71012. Epub 2026 Apr 10. PMID- 41959702 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260410 LR - 20260813 IS - 2215-0161 (Print) IS - 2215-0161 (Electronic) IS - 2215-0161 (Linking) VI - 16 DP - 2026 Jun TI - Effectiveness of a structured physiotherapy intervention on psychomotor and quality of life in children with autism spectrum disorder: A randomised controlled trial protocol. PG - 103873 LID - 10.1016/j.mex.2026.103873 [doi] LID - 103873 AB - Children with Autism Spectrum Disorder (ASD) frequently experience psychomotor impairments, limited participation in physical activities, and reduced quality of life (QoL). Exercise shows promising benefits, but physiotherapy approaches in ASD are underreported, with limited evidence supporting a structured framework that systematically targets motor and functional outcomes. This study protocol describes a single-blinded randomised controlled trial evaluating the effectiveness of a structured physiotherapy intervention on motor skills, physical activity levels, and behavioural and QoL among children with mild to moderate ASD. This trial will include 64 children aged 6-10 years with ASD. Participants will be randomly assigned to an intervention group or a control group. Both groups will receive usual care therapy, equated between groups. The intervention group will also receive structured physiotherapy twice weekly for 12 weeks, each session lasting 60 min. The intervention integrates coordination, balance, strength, and endurance training. Outcome assessments will be conducted at baseline and post-intervention using validated instruments: GARS-3, BOT-2, GLTEQ, CBCL and PedsQL. Data analysis will follow the intention-to-treat principle and will examine between-group and within-group changes across all outcome measures. Qualitative data will be analysed using thematic analysis to characterise themes reflecting participants' engagement and parents' and caregivers' perspectives on the intervention. CI - (c) 2026 The Authors. FAU - Alwi, Nazurah AU - Alwi N AD - Physiotherapy Programme, Centre for Rehabilitation and Special Needs Studies, Faculty of Health Science, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia. FAU - Zanudin, Asfarina AU - Zanudin A AD - Physiotherapy Programme, Centre for Rehabilitation and Special Needs Studies, Faculty of Health Science, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia. FAU - Ahmad, Mahadir AU - Ahmad M AD - Clinical Psychology Programme, Centre for Community Health Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300, Kuala Lumpur, Wilayah Persekutuan Kuala Lumpur, Malaysia. FAU - Mohamad, Nor Azizah AU - Mohamad NA AD - Physiotherapy Unit, Department of Rehabilitation, UKM Specialist Children's Hospital, Jalan Yaacob Latif, Bandar Tun Razak, Cheras, 56000 Kuala Lumpur, Malaysia. LA - eng PT - Journal Article DEP - 20260318 PL - Netherlands TA - MethodsX JT - MethodsX JID - 101639829 PMC - PMC13059026 OTO - NOTNLM OT - Autism spectrum disorder OT - Motor-based intervention OT - Physiotherapy OT - Psychomotor OT - Quality of life COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/10 06:32 MHDA- 2026/04/10 06:33 PMCR- 2026/03/18 CRDT- 2026/04/10 05:36 PHST- 2025/11/30 00:00 [received] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/04/10 06:33 [medline] PHST- 2026/04/10 06:32 [pubmed] PHST- 2026/04/10 05:36 [entrez] PHST- 2026/03/18 00:00 [pmc-release] AID - S2215-0161(26)00091-9 [pii] AID - 103873 [pii] AID - 10.1016/j.mex.2026.103873 [doi] PST - epublish SO - MethodsX. 2026 Mar 18;16:103873. doi: 10.1016/j.mex.2026.103873. eCollection 2026 Jun. PMID- 41958321 OWN - NLM STAT- Publisher LR - 20260410 IS - 1464-5165 (Electronic) IS - 0963-8288 (Linking) DP - 2026 Apr 10 TI - Functional physical therapy applied by telerehabilitation or in-person in infants at risk of cerebral palsy: feasibility and preliminary efficacy. PG - 1-14 LID - 10.1080/09638288.2026.2654116 [doi] AB - PURPOSE: The aim was to assess the feasibility and effectiveness of a goal-oriented training applied by telerehabilitation and face-to-face, for infants at risk of cerebral palsy (CP). METHODS: In a pilot study of a randomized controlled trial, 14 at-risk infants for CP were allocated into telerehabilitation and in-person groups. Over eight weeks, infants underwent functional physical therapy five times weekly; one session of telerehabilitation conducted via video calls or one session of in-person intervention at the clinic. Caregivers also provided unsupervised home activities four times weekly in both groups. Feasibility was assessed through diaries, and caregiver acceptability was measured using questionnaires. Infant motor function was evaluated using the Gross Motor Function Measure (GMFM). RESULTS: Both methods of delivery were feasible for recruitment and assessment. Caregivers expressed high acceptability for both modalities, although in-person participants presented more challenges in home implementation. Both groups showed a significant gap between planned and delivered dosage of intervention. They showed significant motor improvement over time, with no differences between groups. CONCLUSIONS: Telerehabilitation achieved short-term outcomes comparable to conventional therapy in this pilot sample. These preliminary results support the viability of a phase II clinical trial, using the current protocols with modifications. TRIAL REGISTRATION NUMBER: REBEC-RBR-3vhw2hx. FAU - Dos Santos, Adriana Neves AU - Dos Santos AN AD - Department of Health Science, Physical Therapy Graduation Program, Rehabilitation in Health Science Post-Graduation Program, Federal University of Santa Catarina, Ararangua, Brazil. AD - Department of Physical Therapy, Federal University of Sao Carlos, Sao Carlos, Brazil. FAU - Schlichting, Tatiane AU - Schlichting T AD - Department of Health Science, Physical Therapy Graduation Program, Rehabilitation in Health Science Post-Graduation Program, Federal University of Santa Catarina, Ararangua, Brazil. FAU - da Silva Cardoso, Pedro AU - da Silva Cardoso P AD - Department of Health Science, Physical Therapy Graduation Program, Rehabilitation in Health Science Post-Graduation Program, Federal University of Santa Catarina, Ararangua, Brazil. FAU - Longo, Egmar AU - Longo E AD - Department of Physical Therapy, Federal University of Paraiba, Joao Pessoa, Brazil. FAU - Boyd, Roslyn AU - Boyd R AD - Queensland Cerebral Palsy Research Centre, The University of Queensland, Brisbane, Australia. FAU - Cicuto Ferreira Rocha, Nelci Adriana AU - Cicuto Ferreira Rocha NA AD - Department of Physical Therapy, Federal University of Sao Carlos, Sao Carlos, Brazil. LA - eng PT - Journal Article DEP - 20260410 PL - England TA - Disabil Rehabil JT - Disability and rehabilitation JID - 9207179 SB - IM OAB - Telerehabilitation is a potential method for delivering rehabilitation services, including guided therapeutic exercises and caregiver coaching, to infants at risk of cerebral palsy (CP).It was found that telerehabilitation is viable and accepted by the parents.Telerehabilitation and face-to-face intervention seems to improve gross motor function over time equally for infants at risk of CP.Health professionals may consider telerehabilitation as an alternative method for delivering rehabilitation services. OABL- eng OTO - NOTNLM OT - Telemedicine OT - development OT - infancy OT - telehealth OT - telerehabilitation EDAT- 2026/04/10 06:33 MHDA- 2026/04/10 06:33 CRDT- 2026/04/10 04:03 PHST- 2026/04/10 06:33 [medline] PHST- 2026/04/10 06:33 [pubmed] PHST- 2026/04/10 04:03 [entrez] AID - 10.1080/09638288.2026.2654116 [doi] PST - aheadofprint SO - Disabil Rehabil. 2026 Apr 10:1-14. doi: 10.1080/09638288.2026.2654116. PMID- 41957688 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20261016 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Apr 10 TI - Association between dietary self-perception and sugar-sweetened beverage consumption among young adult Latinas. PG - e102 LID - 10.1017/S1368980026102523 [doi] LID - e102 AB - OBJECTIVE: To investigate the relationship between self-perceived overall dietary healthfulness and self-reported sugar-sweetened beverage (SSB) consumption among young adult Latinas, accounting for socio-economic and acculturation-related factors. DESIGN: Cross-sectional analysis using survey data. SSB intake was assessed using the BEVQ-15, and dietary self-perception was measured via a two-item scale. Multiple linear regression models examined associations between self-perception and total daily SSB intake, adjusting for income, education and two validated acculturation indicators. SETTING: Participants were recruited from a national online panel across the USA. PARTICIPANTS: A total of 881 Latina women aged 18-29 years participated. After removing cases with invalid outcome responses and outliers, 840 and 829 were included in descriptive and regression analyses. RESULTS: Better dietary self-perception was significantly associated with greater total SSB intake in both unadjusted (B = 1.74, P = 0.048) and fully adjusted models (B = 2.10, P = 0.017). Lower income (B = -0.64, P = 0.031) and lower education (B = -0.77, P = 0.026) were also associated with higher intake. Acculturation variables were NS. Subcategory models showed positive associations between self-perception and sweet tea (B = 0.99, P < 0.001) and black coffee/tea with sugar (B = 0.51, P < 0.01) and a marginal inverse association with soft drinks (B = -0.47, P = 0.060). CONCLUSIONS: Young Latinas who perceive their diets as healthy may consume more added sugar from beverages than recommended. Public health efforts should address this perception gap and emphasise culturally relevant messaging about hidden sugars in commonly consumed drinks. FAU - Zhou, Mi AU - Zhou M AUID- ORCID: 0000-0001-8822-4188 AD - Department of Nutrition, Food Science, and Packaging, https://ror.org/04qyvz380San Jose State University, USA. FAU - Ramirez, A Susana AU - Ramirez AS AD - Department of Public Health, University of California Merced, USA. FAU - Xu, Xinyu AU - Xu X AD - Department of Nutrition, Food Science, and Packaging, https://ror.org/04qyvz380San Jose State University, USA. FAU - Bergman, Jacqueline AU - Bergman J AD - Department of Nutrition, Food Science, and Packaging, https://ror.org/04qyvz380San Jose State University, USA. LA - eng GR - P30 DK092924/DK/NIDDK NIH HHS/United States GR - R01DK116852/NH/NIH HHS/United States GR - P30DK092924/DK/NIDDK NIH HHS/United States GR - K01CA190659/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20260410 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Young Adult MH - Acculturation MH - Cross-Sectional Studies MH - *Diet/ethnology/psychology MH - Feeding Behavior/ethnology/psychology MH - *Hispanic or Latino/psychology/statistics & numerical data MH - *Self Concept MH - Socioeconomic Factors MH - *Sugar-Sweetened Beverages/statistics & numerical data MH - United States PMC - PMC13434627 OTO - NOTNLM OT - Acculturation OT - Beverage consumption OT - Dietary behaviours OT - Dietary self-perception OT - Latinas OT - Sugar-sweetened beverages COIS- There are no conflicts of interest. EDAT- 2026/04/10 06:33 MHDA- 2026/05/07 06:38 PMCR- 2026/04/10 CRDT- 2026/04/10 00:02 PHST- 2026/05/07 06:38 [medline] PHST- 2026/04/10 06:33 [pubmed] PHST- 2026/04/10 00:02 [entrez] PHST- 2026/04/10 00:00 [pmc-release] AID - S1368980026102523 [pii] AID - 10.1017/S1368980026102523 [doi] PST - epublish SO - Public Health Nutr. 2026 Apr 10;29(1):e102. doi: 10.1017/S1368980026102523. PMID- 41957451 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Apr 9 TI - The role of habit strength in the theory of planned behavior for fruit and vegetable intake among women in Saudi Arabia. LID - 10.1038/s41598-026-47394-w [doi] LID - 16763 AB - Low fruit and vegetable (F&V) consumption is prevalent among Saudi women, despite global health recommendations. To identify the psychological determinants of F&V intake using the theory of planned behavior (TPB) and to examine the moderating role of habit. A cross-sectional survey was conducted among 467 adult Saudi women. The questionnaire measured TPB constructs-attitude, subjective norm (SN), perceived behavioral control (PBC), intention, and behavior-alongside habit strength using a validated self-report habit index. Structural equation modeling (SEM) tested the TPB model, and multi-group analysis examined differences across low, medium, and high habit levels. Only 22.3% of women met the WHO recommendation of >/= 5 F&V servings daily, with significant variation by habit level (10.2% low-habit vs. 30.5% high-habit; p < 0.001). The high habit group showed significantly better knowledge of WHO recommendations (p = 0.013), healthier dietary perceptions (p < 0.001), and more frequent purchasing and preparation of F&V (p < 0.001). Physical activity also increased with habit strength (p < 0.001). Compared to the low-habit group, women in the high-habit group reported higher scores for all the TPB constructs (p < 0.001). SEM results indicated that the TPB model explained 31% of the variance in behavior and 75% in intention. In the overall sample, both intention (beta = 0.32, p = 0.005) and PBC (beta = 0.26, p = 0.032) predicted F&V intake. PBC was the strongest predictor of intention (beta = 0.66, p < 0.001), followed by SN and attitude. Across habit levels, PBC consistently predicted intention; attitude was significant in the low-habit group, and SN in the high-habit group. Perceived control strongly influences both intention and behavior, but habit moderates these relationships. Interventions should enhance self-efficacy and establish regular F&V consumption among Saudi women. CI - (c) 2026. The Author(s). FAU - Alshaalan, Rasha AU - Alshaalan R AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, P.O. Box 84428, 11671, Riyadh, Saudi Arabia. FAU - Alhassani, Walaa Essam AU - Alhassani WE AD - Clinical Nutrition Department, Faculty of Applied Medical Sciences, Umm Al-Qura University, P.O. Box 715, 21955, Makkah, Saudi Arabia. FAU - Alasmari, Sarah A AU - Alasmari SA AD - Public Health Department, College of Health Sciences, Saudi Electronic University, Riyadh, Saudi Arabia. FAU - Allily, Rowida Khader AU - Allily RK AD - Food and Nutrition Department, Human Sciences and Design Faculty, King Abdulaziz University, Jeddah, 22258, Saudi Arabia. FAU - Alharbi, Nouf Abdullah AU - Alharbi NA AD - Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, P.O. Box 6666, 51452, Buraydah, Saudi Arabia. FAU - Wazzan, Huda AU - Wazzan H AD - Food and Nutrition Department, Human Sciences and Design Faculty, King Abdulaziz University, Jeddah, 22258, Saudi Arabia. FAU - Jalloun, Rola Adnan AU - Jalloun RA AD - Department of Clinical Nutrition, College of Applied Medical Sciences, Taibah University, Universities Road, P.O. Box 344, Medina, Saudi Arabia. FAU - Jan, Majd AU - Jan M AD - Department of Clinical Pharmacy and Pharmacology, Ibn Sina National College for Medical Studies, Jeddah, Saudi Arabia. FAU - Hanbazaza, Mahitab A AU - Hanbazaza MA AD - Food and Nutrition Department, Human Sciences and Design Faculty, King Abdulaziz University, Jeddah, 22258, Saudi Arabia. FAU - Benajiba, Nada AU - Benajiba N AD - Joint Research Unit in Nutrition and Food, RDC-Nutrition AFRA/IAEA, Ibn Tofail University-CNESTEN, 14000, Rabat, Kenitra, Morocco. benajibanada@gmail.com. LA - eng PT - Journal Article DEP - 20260409 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Saudi Arabia MH - Theory of Planned Behavior MH - *Vegetables MH - Adult MH - *Fruit MH - Cross-Sectional Studies MH - *Feeding Behavior/psychology MH - Young Adult MH - Middle Aged MH - Surveys and Questionnaires MH - *Habits MH - Health Behavior MH - Health Knowledge, Attitudes, Practice MH - Adolescent PMC - PMC13223323 OTO - NOTNLM OT - Dietary behavior OT - Fruit and vegetable consumption OT - Habit OT - Saudi women OT - Theory of planned behavior COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical statement: The IRB approval was obtained from the IRB committee at the University before collecting the data from the participants through the online questionnaire. Consent to participate: Every human participant has provided his/her consent to participate in the study. EDAT- 2026/04/10 00:33 MHDA- 2026/06/01 00:33 PMCR- 2026/04/09 CRDT- 2026/04/09 23:38 PHST- 2025/11/04 00:00 [received] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/06/01 00:33 [medline] PHST- 2026/04/10 00:33 [pubmed] PHST- 2026/04/09 23:38 [entrez] PHST- 2026/04/09 00:00 [pmc-release] AID - 10.1038/s41598-026-47394-w [pii] AID - 47394 [pii] AID - 10.1038/s41598-026-47394-w [doi] PST - epublish SO - Sci Rep. 2026 Apr 9;16(1):16763. doi: 10.1038/s41598-026-47394-w. PMID- 41956708 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260921 IS - 2056-5933 (Electronic) IS - 2056-5933 (Linking) VI - 12 IP - 2 DP - 2026 Apr 9 TI - Birth length and perinatal exposures and rheumatoid arthritis risk in the E3N cohort. LID - 10.1136/rmdopen-2025-006415 [doi] LID - e006415 AB - OBJECTIVE: To examine associations between participants' perinatal factors, including harmonised birth weight and length, prematurity, exposure to maternal smoking during pregnancy and breastfeeding during infancy, and incident rheumatoid arthritis (RA) in a large prospective cohort of French women. METHODS: The Etude Epidemiologique aupres des femmes de la Mutuelle generale de l'Education Nationale (E3N) cohort enrolled 98 995 women in 1990. Perinatal data were collected in 2002. Birth weight and length were reported continuously and/or categorically and harmonised according to term status. RA cases were validated using a specific questionnaire. Adjusted HRs (aHRs) and 95% CIs were estimated using Cox proportional hazards models informed by a directed acyclic graph. RESULTS: Among 78 473 women, 698 incident RA cases were identified. No evidence of an association was observed between perinatal factors and RA risk in the overall population. Point estimates for large birth length (aHR 1.32, 95% CI 0.97 to 1.78) and preterm birth (aHR 1.34, 95% CI 0.92 to 1.94) were above 1, but CIs included the null value of 1.In sensitivity analyses restricted to women with continuous birth data, a signal for large birth length was observed (aHR 1.98, 95% CI 1.23 to 3.19), whereas no such signal was detected when using categorised self-reported measures. CONCLUSIONS: In this large prospective cohort, most perinatal factors were not associated with RA risk in adulthood. A signal related to larger birth length emerged only in selected analyses based on more precise exposure assessment and should be interpreted cautiously. These findings are hypothesis-generating and warrant replication in independent cohorts using prospectively measured perinatal data. TRIAL REGISTRATION NUMBER: NCT03285230. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Dusser, Perrine AU - Dusser P AUID- ORCID: 0000-0001-8118-0848 AD - Universite Paris-Saclay, UVSQ, Universite Paris-Sud, Centre for Research in Epidemiology and Population Health (CESP), 'Exposome and Heredity' Team, Institut pour la Sante et la Recherche Medicale (INSERM), Gustave Roussy, Villejuif, France. AD - Pediatric Rheumatology Department, Assistance Publique-Hopitaux de Paris (AP-HP), Hopitaux universitaires Paris-Sud - Hopital Bicetre, Le Kremlin-Bicetr, Paris, France. FAU - Nguyen, Yann AU - Nguyen Y AUID- ORCID: 0000-0002-0866-3824 AD - Department of Internal Medicine, AP-HP-Hopital Beaujon, Paris University, Clichy, France. AD - Centre de recherche en immunologie des maladies, INSERM U1184, Universite Paris Saclay, Le Kremlin-Bicetre, France. FAU - Perrin, Claire AU - Perrin C AD - Universite Paris-Saclay, UVSQ, Universite Paris-Sud, Centre for Research in Epidemiology and Population Health (CESP), 'Exposome and Heredity' Team, Institut pour la Sante et la Recherche Medicale (INSERM), Gustave Roussy, Villejuif, France. FAU - Frenoy, Pauline AU - Frenoy P AD - Universite Paris-Saclay, UVSQ, Universite Paris-Sud, Centre for Research in Epidemiology and Population Health (CESP), 'Exposome and Heredity' Team, Institut pour la Sante et la Recherche Medicale (INSERM), Gustave Roussy, Villejuif, France. FAU - Mariette, Xavier AU - Mariette X AUID- ORCID: 0000-0002-4244-5417 AD - Rheumatology Department, Assistance Publique-Hopitaux de Paris (AP-HP), Hopitaux universitaires Paris-Sud - Hopital Bicetre, Le Kremlin-Bicetre, Paris, France. AD - Universite Paris-Saclay, Center of Immunology of Viral Infections and Auto-immune Diseases (IMVA), Institut pour la Sante et la Recherche Medicale (INSERM) U1184, Le Kremlin-Bicetre, Paris, France. FAU - Boutron-Ruault, Marie-Christine AU - Boutron-Ruault MC AD - Universite Paris-Saclay, UVSQ, Universite Paris-Sud, Centre for Research in Epidemiology and Population Health (CESP), 'Exposome and Heredity' Team, Institut pour la Sante et la Recherche Medicale (INSERM), Gustave Roussy, Villejuif, France. FAU - Severi, Gianluca AU - Severi G AD - Universite Paris-Saclay, UVSQ, Universite Paris-Sud, Centre for Research in Epidemiology and Population Health (CESP), 'Exposome and Heredity' Team, Institut pour la Sante et la Recherche Medicale (INSERM), Gustave Roussy, Villejuif, France. AD - Department of Statistics, Computer Science, Applications 'G. Parenti', University of Florence, Florence, Italy. FAU - Salliot, Carine AU - Salliot C AUID- ORCID: 0000-0003-1066-4161 AD - Laboratoire Interdisciplinaire pour l'Innovation et la Recherche en Sante Orleanaise (LI(2)RSO), Universite d'Orleans, Orleans, France. AD - Rheumatology Department, Centre Hospitalier Universitaire d'Orleans, Universite d'Orleans, Orleans, France. FAU - Seror, Raphaele AU - Seror R AUID- ORCID: 0000-0002-5523-1856 AD - Rheumatology Department, Assistance Publique-Hopitaux de Paris (AP-HP), Hopitaux universitaires Paris-Sud - Hopital Bicetre, Le Kremlin-Bicetre, Paris, France raphaele.seror@aphp.fr. AD - Universite Paris-Saclay, Center of Immunology of Viral Infections and Auto-immune Diseases (IMVA), Institut pour la Sante et la Recherche Medicale (INSERM) U1184, Le Kremlin-Bicetre, Paris, France. LA - eng SI - ClinicalTrials.gov/NCT03285230 PT - Journal Article PT - Observational Study DEP - 20260409 PL - England TA - RMD Open JT - RMD open JID - 101662038 SB - IM MH - Adult MH - Female MH - Humans MH - Infant, Newborn MH - Pregnancy MH - *Arthritis, Rheumatoid/epidemiology/etiology MH - *Birth Weight MH - Breast Feeding MH - France/epidemiology MH - Incidence MH - *Maternal Exposure/adverse effects MH - Premature Birth/epidemiology MH - *Prenatal Exposure Delayed Effects/epidemiology MH - Prospective Studies MH - Risk Factors PMC - PMC13084943 OTO - NOTNLM OT - Autoimmune Diseases OT - Epidemiology OT - Rheumatoid Arthritis COIS- Competing interests: RS received consulting fees from GSK, Bristol Myers Squibb, Boehringer and Janssen; honoraria from GSK, Bristol Myers Squibb, Boehringer, Amgen, Pfizer and Roche; travel fees from Amgen and GSK, outside of the topic of this study. CS received consulting fees from Novartis; honouraria from Pfizer, Galapagos, Fresenius Kabi, Novartis; travel fees from Lilly and Galapagos, outside of the topic of this study. PD received congress fees from SOBI, Novartis, Abbvie, Pfizer and Lilly outside of the topic of this study. The other authors have no conflicts of interest relevant to this article to disclose. EDAT- 2026/04/10 00:33 MHDA- 2026/04/10 00:34 PMCR- 2026/04/09 CRDT- 2026/04/09 21:13 PHST- 2025/10/03 00:00 [received] PHST- 2026/01/08 00:00 [accepted] PHST- 2026/04/10 00:34 [medline] PHST- 2026/04/10 00:33 [pubmed] PHST- 2026/04/09 21:13 [entrez] PHST- 2026/04/09 00:00 [pmc-release] AID - rmdopen-2025-006415 [pii] AID - 10.1136/rmdopen-2025-006415 [doi] PST - epublish SO - RMD Open. 2026 Apr 9;12(2):e006415. doi: 10.1136/rmdopen-2025-006415. PMID- 41955738 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260714 IS - 1469-0705 (Electronic) IS - 0960-7692 (Linking) VI - 67 IP - 5 DP - 2026 May TI - Can we define a cut-off for external anal sphincter defect angle? PG - 684-689 LID - 10.1002/uog.70216 [doi] AB - OBJECTIVES: Obstetric anal sphincter injury is a common complication of childbirth and the primary etiological factor for anal incontinence in young women. On endoanal ultrasound, a significant defect of the external anal sphincter (EAS) has arbitrarily been defined as a gap of greater than 30 degrees in its hyperechogenic ring structure. This study was designed to validate a cut-off value for defining a significant EAS defect on tomographic exoanal imaging. METHODS: This was a retrospective study involving women attending a tertiary urogynecological unit between January 2015 and December 2021. Analysis was limited to premenopausal women to reduce confounders. The assessment included obtaining the St Mark's incontinence score and visual analog scale (VAS) bother score of anal incontinence, and performance of four-dimensional transperineal exoanal ultrasound. Tomographic ultrasound imaging (TUI) was used to evaluate the EAS; offline analysis was performed at a later date, with the assessor blinded against all other clinical data. The primary measure to assess EAS defects was defect angle. Associations between this parameter and anal incontinence, VAS bother score and St Mark's score were estimated using univariable logistic or linear regression models. Receiver-operating-characteristics (ROC)-curve analysis was performed to determine the optimal cut-off value of the EAS defect angle for defining a significant defect. RESULTS: A total of 915 premenopausal women were seen during the study period. Ultrasound volumes of the anal canal were missing in 64 women and one patient was excluded due to muscular dystrophy, leaving 850 women included in the analysis. The mean age was 42 (range, 18-56) years and the mean body mass index was 29 (range, 16-57) kg/m(2) at assessment. Anal incontinence was reported by 133 (16%) women, with a median St Mark's score of 10 (interquartile range, 6-14) and a mean VAS bother score of 6.6 (range, 0-10). On TUI, six slices were scored per patient (total of 5100 assessments). EAS defects were seen in 111 (13%) patients and 368 slices, with an average defect angle of 32 degrees (range, 2-155 degrees ) and a mean maximum defect angle of 67 degrees (range, 14-167 degrees ). Average defect angle showed the strongest correlation with anal incontinence, St Mark's score and VAS bother score (all P < 0.001). ROC-curve analysis suggested a cut-off of 30 degrees for the definition of a significant EAS defect. CONCLUSION: In premenopausal women, EAS defects on TUI were associated significantly with all investigated measures of anal incontinence. Average defect angle was the best predictor of anal incontinence and enabled ROC-curve analysis. The 30 degrees defect angle criterion empirically used for endoanal ultrasound seemed to be valid as a cut-off for the diagnosis of significant anal sphincter defect on exoanal imaging. (c) 2026 International Society of Ultrasound in Obstetrics and Gynecology. CI - (c) 2026 International Society of Ultrasound in Obstetrics and Gynecology. FAU - Dietz, H P AU - Dietz HP AUID- ORCID: 0000-0002-2211-6149 AD - Sydney Urodynamic Centres, Sydney, NSW, Australia. FAU - Shek, K L AU - Shek KL AUID- ORCID: 0000-0001-6836-4474 AD - Liverpool Clinical School, Western Sydney University, Sydney, NSW, Australia. FAU - Descallar, J AU - Descallar J AD - Ingham Institute for Applied Medical Research, Liverpool, NSW, Australia. AD - South West Sydney Clinical Campuses, School of Clinical Medicine, UNSW Sydney, Liverpool, NSW, Australia. LA - eng PT - Journal Article DEP - 20260409 PL - England TA - Ultrasound Obstet Gynecol JT - Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology JID - 9108340 SB - IM MH - Humans MH - Female MH - *Anal Canal/diagnostic imaging/injuries MH - Adult MH - Retrospective Studies MH - *Fecal Incontinence/etiology/diagnostic imaging MH - Pregnancy MH - *Endosonography/methods MH - ROC Curve MH - Ultrasonography/methods MH - *Delivery, Obstetric/adverse effects MH - Young Adult OTO - NOTNLM OT - birth trauma OT - exoanal ultrasound OT - external anal sphincter OT - obstetric anal sphincter injury OT - sphincter tears EDAT- 2026/04/10 00:33 MHDA- 2026/05/04 00:31 CRDT- 2026/04/09 18:03 PHST- 2025/10/16 00:00 [revised] PHST- 2025/07/10 00:00 [received] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/05/04 00:31 [medline] PHST- 2026/04/10 00:33 [pubmed] PHST- 2026/04/09 18:03 [entrez] AID - 10.1002/uog.70216 [doi] PST - ppublish SO - Ultrasound Obstet Gynecol. 2026 May;67(5):684-689. doi: 10.1002/uog.70216. Epub 2026 Apr 9. PMID- 41955508 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260909 IS - 2379-3708 (Electronic) IS - 2379-3708 (Linking) VI - 11 IP - 9 DP - 2026 May 8 TI - Plant-based enteral nutrition outperforms ultra-processed formulas in mitigating consequences of antibiotic-induced dysbiosis. LID - 10.1172/jci.insight.199827 [doi] LID - e199827 AB - Malnutrition, gut inflammation, and antibiotic-induced dysbiosis are well-recognized risk factors for poor clinical outcomes among critically ill patients. We previously showed that commercially available plant-based enteral nutrition (PBEN) preserves a commensal microbiome compared with commonly used artificial enteral nutrition (AEN). In this study, PBEN was superior to AEN in promoting recovery from antibiotic-induced dysbiosis in mice and humans. PBEN effectively mitigated anemia and leukopenia, restored naive lymphocyte populations, and reduced bone marrow myeloid expansion. Animals randomized to PBEN also exhibited improved responses to infectious gastrointestinal challenges following antibiotic exposure. A pilot clinical study validated these findings, demonstrating increased gut commensals, reduced pathogens, and improved leukocyte balance in critically ill children receiving PBEN compared with AEN. Together, these results suggest that PBEN offers a practical dietary approach to mitigate antibiotic-associated complications and potentially improve clinical outcomes among hospitalized patients requiring supplemental nutrition. FAU - Chatrizeh, Mona AU - Chatrizeh M AD - Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Tian, Jianmin AU - Tian J AD - Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Rogers, Matthew AU - Rogers M AD - Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Feturi, Firuz AU - Feturi F AD - Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Wu, Guojun AU - Wu G AD - Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Firek, Brian AU - Firek B AD - Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Nikonov, Roman AU - Nikonov R AD - Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Cass, Lauren AU - Cass L AD - Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Sheppeck, Alexandra AU - Sheppeck A AD - Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Ojha, Lavnish AU - Ojha L AD - Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Carroll, Ali AU - Carroll A AD - Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Henkel, Matthew AU - Henkel M AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. AD - Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. FAU - Azar, Justin AU - Azar J AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. AD - Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Aneja, Rajesh K AU - Aneja RK AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. AD - Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Campfield, Brian AU - Campfield B AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. AD - Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. FAU - Simon, Dennis AU - Simon D AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. AD - Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. AD - Department of Critical Care Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Morowitz, Michael J AU - Morowitz MJ AD - Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. AD - UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260409 PL - United States TA - JCI Insight JT - JCI insight JID - 101676073 RN - 0 (Anti-Bacterial Agents) SB - IM UOF - medRxiv. 2025 Mar 20:2025.03.19.25323813. doi: 10.1101/2025.03.19.25323813. PMID: 40166543 MH - Humans MH - Animals MH - *Dysbiosis/chemically induced/therapy MH - *Enteral Nutrition/methods MH - *Anti-Bacterial Agents/adverse effects MH - Mice MH - Gastrointestinal Microbiome/drug effects MH - Female MH - Male MH - Pilot Projects MH - Critical Illness/therapy MH - Diet, Plant-Based MH - Child, Preschool MH - Child PMC - PMC13232488 OTO - NOTNLM OT - Gastroenterology OT - Immunology OT - Microbiome COIS- The authors have declared that no conflict of interest exists. EDAT- 2026/04/09 18:30 MHDA- 2026/05/08 12:38 PMCR- 2026/04/09 CRDT- 2026/04/09 15:33 PHST- 2025/09/02 00:00 [received] PHST- 2026/03/10 00:00 [accepted] PHST- 2026/05/08 12:38 [medline] PHST- 2026/04/09 18:30 [pubmed] PHST- 2026/04/09 15:33 [entrez] PHST- 2026/04/09 00:00 [pmc-release] AID - 199827 [pii] AID - 10.1172/jci.insight.199827 [doi] PST - epublish SO - JCI Insight. 2026 Apr 9;11(9):e199827. doi: 10.1172/jci.insight.199827. eCollection 2026 May 8. PMID- 41955236 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 4 DP - 2026 TI - Maternal serum progesterone and BMI are associated with neonatal sex ratios following single frozen embryo transfer. PG - e0346711 LID - 10.1371/journal.pone.0346711 [doi] LID - e0346711 AB - BACKGROUND: The biological mechanisms behind sex ratio variation in assisted reproductive technologies (ART) are not well understood. This study investigated whether maternal serum progesterone (PRG) and body mass index (BMI) are related to neonatal sex after frozen-thawed embryo transfer (FET). METHODS: We conducted a retrospective cohort study of 998 single blastocyst FET cycles performed under a freeze-all strategy from 2019 to 2023. Maternal BMI and serum PRG measured in the peri-transfer period were analyzed in relation to neonatal sex. Receiver operating characteristic (ROC) analyses identified predictive thresholds. Associations were evaluated using multivariable logistic regression models adjusted for potential confounders. RESULTS: ROC analyses identified PRG /= 50% goal. The patients were endotracheally intubated and receiving mechanical ventilation. RESULTS: The study cohort included 45 patients, 29 receiving nasogastric (NG) feeds and 16 receiving NJ feeds. The majority of patients (81%) receiving post-pyloric feeds had gastric volumes /= 2 mL/kg while more than half of NG-fed patients (53%) had gastric volumes >/= 2 mL/kg. Only three of 18 patients (18.8%) receiving NJ feeds had a gastric volume greater than 0.4 mL/kg. When grading the aspiration risk, there was a higher aspiration risk with NG feeds compared to NJ feeds (33/39 versus 0/18, P < 0.001). CONCLUSION: Gastric volumes and hence the potential aspiration risk is decreased in patients receiving post-pyloric compared to NG feeds. CI - Copyright 2026 Authors. FAU - Montet, Timothy AU - Montet T AD - Department of Anesthesiology & Pain Medicine, Nationwide Children's Hospital, Columbus, OH, USA. FAU - Lin, Ada AU - Lin A AD - Division of Pediatric Critical Care Medicine, Nationwide Children's Hospital and Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA. FAU - Yemele Kitio, Sibelle Aurelie AU - Yemele Kitio SA AD - Department of Anesthesiology & Pain Medicine, Nationwide Children's Hospital, Columbus, OH, USA. FAU - Tobias, Joseph D AU - Tobias JD AD - Department of Anesthesiology & Pain Medicine, Nationwide Children's Hospital, Columbus, OH, USA. AD - Department of Anesthesiology & Pain Medicine, The Ohio State University College of Medicine, Columbus, OH, USA. FAU - Moharir, Alok AU - Moharir A AD - Department of Anesthesiology & Pain Medicine, Nationwide Children's Hospital, Columbus, OH, USA. AD - Department of Anesthesiology & Pain Medicine, The Ohio State University College of Medicine, Columbus, OH, USA. LA - eng PT - Journal Article DEP - 20260326 PL - Canada TA - J Clin Med Res JT - Journal of clinical medicine research JID - 101538301 PMC - PMC13053576 OTO - NOTNLM OT - Aspiration OT - Enteral feedings OT - Point-of-care ultrasound OT - Ultrasonography COIS- The authors deny any conflict of interest. EDAT- 2026/04/09 06:33 MHDA- 2026/04/09 06:34 PMCR- 2026/03/26 CRDT- 2026/04/09 04:44 PHST- 2026/01/15 00:00 [received] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/04/09 06:34 [medline] PHST- 2026/04/09 06:33 [pubmed] PHST- 2026/04/09 04:44 [entrez] PHST- 2026/03/26 00:00 [pmc-release] AID - 10.14740/jocmr6506 [doi] PST - epublish SO - J Clin Med Res. 2026 Mar 26;18(3):205-210. doi: 10.14740/jocmr6506. eCollection 2026 Mar. PMID- 41953322 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260409 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Psychometric properties of Rosenberg's self-esteem scale among adolescents: a Rasch model analysis. PG - 1704135 LID - 10.3389/fpsyg.2026.1704135 [doi] LID - 1704135 AB - BACKGROUND: The Rosenberg Self-Esteem Scale (RSES) is one of the most widely used measures of global self-esteem. While its psychometric properties have been extensively studied using classical test theory, limited evidence exists on its performance under modern test theory approaches. AIM: To evaluate the psychometric properties of the RSES using Rasch analysis in a sample of Swedish adolescents. METHODS: A total of 403 adolescents (aged 9-19 years) from six schools completed the RSES. Rasch modelling was applied to assess item fit, person-item targeting, response category functioning, reliability, and differential item functioning (DIF) across sex, age, and BMI. RESULTS: The RSES demonstrated good item fit, with most items aligning with the Rasch model assumptions. The reliability and internal consistency indicators were strong, reflecting the sound psychometric quality of the scale. The person reliability coefficient reached a high value (0.85), with PSI = 2.35, indicating the scale's effective ability to discriminate among individuals across different levels of self-esteem. In addition, item reliability was high (0.99), accompanied by ISI = 8.38, reflecting the precision and stability of item difficulty estimates. Cronbach's alpha was 0.87, with SEM = 2.11, all of which confirm a high level of reliability and internal consistency among the scale items. Regarding targeting, the range of participant abilities was broader than that of item difficulties, with adequate coverage of the central portion of the self-esteem continuum, though some challenges remain in representing extreme levels of the trait. DIF analyses revealed no significant bias across sex, age, or BMI, though several items displayed variation across self-esteem levels. CONCLUSION: The RSES showed acceptable Rasch model fit, structural integrity, and reliability among Swedish adolescents, with no evidence of DIF by sex, age, or BMI. However, suboptimal targeting and misfitting reverse-worded items limited measurement precision, particularly at very low and very high self-esteem levels. Adding items targeting the extremes and revising problematic items could enhance the RSES's utility for adolescent self-esteem assessment in both research and clinical contexts. CI - Copyright (c) 2026 Khalaf, Ziad, Ny and Hammarlund. FAU - Khalaf, Atika AU - Khalaf A AD - The PRO-CARE Group, Faculty of Health Sciences, Kristianstad University, Kristianstad, Sweden. AD - Hind Bint Maktoum College of Nursing and Midwifery, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai Health, Dubai, United Arab Emirates. FAU - Ziad, Rachid AU - Ziad R AD - Department of Psychology, Echahid Cheikh Larbi Tebessi University, Tebessa, Algeria. FAU - Ny, Pernilla AU - Ny P AD - Department of Health Sciences, Midwifery Research, Reproductive, Perinatal and Sexual Health, Faculty of Medicine, Lund University, Lund, Sweden. FAU - Hammarlund, Catharina Sjodahl AU - Hammarlund CS AD - The PRO-CARE Group, Faculty of Health Sciences, Kristianstad University, Kristianstad, Sweden. AD - Department of Health Sciences, Lund University, Lund, Sweden. LA - eng PT - Journal Article DEP - 20260324 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13055173 OTO - NOTNLM OT - Rasch model analysis OT - Rosenberg's self-esteem scale OT - Sweden OT - adolescents OT - psychometric properties COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/09 06:31 MHDA- 2026/04/09 06:32 PMCR- 2026/03/24 CRDT- 2026/04/09 04:41 PHST- 2025/10/02 00:00 [received] PHST- 2026/02/11 00:00 [revised] PHST- 2026/02/27 00:00 [accepted] PHST- 2026/04/09 06:32 [medline] PHST- 2026/04/09 06:31 [pubmed] PHST- 2026/04/09 04:41 [entrez] PHST- 2026/03/24 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1704135 [doi] PST - epublish SO - Front Psychol. 2026 Mar 24;17:1704135. doi: 10.3389/fpsyg.2026.1704135. eCollection 2026. PMID- 41953185 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260409 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Development and validation of an intraoperative hypothermia risk assessment scale for school-aged children. PG - 1770475 LID - 10.3389/fped.2026.1770475 [doi] LID - 1770475 AB - BACKGROUND: Intraoperative hypothermia (core temperature <36 degrees C) is a common and detrimental complication in pediatric surgery. School-aged children (6-12 years) possess unique physiological vulnerabilities, yet a validated, age-specific risk assessment tool is lacking, leading to potential gaps in targeted prevention. OBJECTIVE: To develop and preliminarily validate a specialized intraoperative hypothermia risk assessment scale for school-aged children undergoing surgery. METHODS: This prospective scale development and validation study had three phases. First, a literature review defined the initial item pool. Second, a two-round Delphi consultation with 16 pediatric surgery experts (authority coefficients: 0.875, 0.900) refined items and confirmed content validity. The Delphi method was chosen for early-phase tool development to achieve clinical face and content validity via expert consensus, with equal item weighting as a starting point for future optimization. Finally, from July to December 2024, the scale was used on 398 school-aged surgical patients at a tertiary children's hospital. Intraoperative nasopharyngeal temperature monitoring was the reference for hypothermia (core temperature <36 degrees C after anesthesia induction). Scale reliability was measured by Cronbach's alpha, and predictive validity was evaluated with ROC curve analysis. RESULTS: The final scale consists of 13 items across two domains: patient-related factors (4 items) and iatrogenic/procedural factors (9 items). Each item is scored 1-3, yielding a total score range of 13-39, with higher scores indicating greater risk. In the validation cohort of 398 patients (211 males, 187 females; mean age 8.4 +/- 2.1 years), the incidence of intraoperative hypothermia was 47.2% (188/398). Baseline characteristics revealed mean BMI 16.8 +/- 3.2 kg/m(2), 62.3% undergoing general anesthesia, and mean surgical duration 2.1 +/- 1.4 h. The scale demonstrated acceptable internal consistency (Cronbach's alpha = 0.731). The ROC analysis revealed an Area Under the Curve (AUC) of 0.743 (95% CI: 0.692-0.794, P < 0.001), indicating fair discriminative ability. The optimal cut-off score was 28, achieving a sensitivity of 0.752 and a specificity of 0.640 for predicting hypothermia. CONCLUSION: We developed a novel, reliable, and valid risk assessment scale for intraoperative hypothermia in school-aged children. This tool enables risk stratification using preoperatively available information to facilitate individualized warming strategies and potentially improve perioperative outcomes. Further multi-center validation is warranted to confirm its generalizability. CI - (c) 2026 Du, Wang, Yang, Liu, Cao, Xia and Yang. FAU - Du, Qingqing AU - Du Q AD - Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Tongji University School of Medicine, Shanghai, China. FAU - Wang, Zhen AU - Wang Z AD - Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Yang, Lei AU - Yang L AD - Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Liu, Yingmin AU - Liu Y AD - Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Cao, Jing AU - Cao J AD - Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Xia, Mengfan AU - Xia M AD - Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Yang, Xia AU - Yang X AD - Shanghai Children's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. LA - eng PT - Journal Article DEP - 20260324 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13055600 OTO - NOTNLM OT - child OT - hypothermia OT - intraoperative complications OT - predictive value OT - risk assessment OT - scale development COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/09 06:32 MHDA- 2026/04/09 06:33 PMCR- 2026/03/24 CRDT- 2026/04/09 04:39 PHST- 2025/12/18 00:00 [received] PHST- 2026/02/18 00:00 [revised] PHST- 2026/02/26 00:00 [accepted] PHST- 2026/04/09 06:33 [medline] PHST- 2026/04/09 06:32 [pubmed] PHST- 2026/04/09 04:39 [entrez] PHST- 2026/03/24 00:00 [pmc-release] AID - 10.3389/fped.2026.1770475 [doi] PST - epublish SO - Front Pediatr. 2026 Mar 24;14:1770475. doi: 10.3389/fped.2026.1770475. eCollection 2026. PMID- 41953182 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260409 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Development of a risk prediction model for central venous catheter insertion-related thrombosis in critically ill pediatric patients. PG - 1666896 LID - 10.3389/fped.2026.1666896 [doi] LID - 1666896 AB - INTRODUCTION: Central venous catheter-related thrombosis (CVC-RT) is a serious complication associated with CVC insertion that significantly adversely affects the prognosis of critically ill children. This study aimed to identify risk factors for CVC-RT following CVC placement in critically ill children and to develop a corresponding risk prediction model. METHODS: A total of 188 critically ill children with CVCs were enrolled and categorized into thrombosis and non-thrombosis groups. Clinical data were collected to analyze risk factors for CVC-RT, and a nomogram prediction model was developed and validated for its predictive performance. RESULTS: Among the 188 children, 31 developed CVC-RT, yielding an incidence rate of 16.5%. Significant differences were observed between the two groups in terms of age, catheter type, parenteral nutrition status, D-dimer levels, and fibrinogen (FIB) levels. All of these factors, except catheter type, were identified as independent predictors of CVC-RT. The constructed nomogram prediction model demonstrated strong predictive performance and discriminative ability, with an area under the receiver operating characteristic curve of 0.952. DISCUSSION: In summary, this study identified age, parenteral nutrition, D-dimer, and FIB levels as independent influencing factors for CVC-RT in critically ill children. The nomogram model incorporating these factors exhibited favorable predictive value. CI - (c) 2026 Zhou, Li, Chen, Zou, Wang and Lei. FAU - Zhou, Xiaolan AU - Zhou X AD - Pediatric Intensive Care Unit, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, China. FAU - Li, Yunrong AU - Li Y AD - Pediatric Intensive Care Unit, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, China. FAU - Chen, Shoushan AU - Chen S AD - Pediatric Intensive Care Unit, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, China. FAU - Zou, Yingbo AU - Zou Y AD - Pediatric Intensive Care Unit, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, China. FAU - Wang, Huan AU - Wang H AD - Pediatric Intensive Care Unit, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, China. FAU - Lei, Li AU - Lei L AD - Pediatric Intensive Care Unit, The First People's Hospital of Zunyi (The Third Affiliated Hospital of Zunyi Medical University), Zunyi, Guizhou, China. LA - eng PT - Journal Article DEP - 20260324 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13054883 OTO - NOTNLM OT - central venous catheters OT - critically ill child OT - nomograms OT - risk factors OT - venous thrombosis COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/09 06:33 MHDA- 2026/04/09 06:34 PMCR- 2026/03/24 CRDT- 2026/04/09 04:39 PHST- 2025/07/16 00:00 [received] PHST- 2026/01/27 00:00 [revised] PHST- 2026/02/10 00:00 [accepted] PHST- 2026/04/09 06:34 [medline] PHST- 2026/04/09 06:33 [pubmed] PHST- 2026/04/09 04:39 [entrez] PHST- 2026/03/24 00:00 [pmc-release] AID - 10.3389/fped.2026.1666896 [doi] PST - epublish SO - Front Pediatr. 2026 Mar 24;14:1666896. doi: 10.3389/fped.2026.1666896. eCollection 2026. PMID- 41952967 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260409 LR - 20260813 IS - 2768-2765 (Electronic) IS - 2768-2765 (Linking) VI - 15 DP - 2026 May TI - Providence Bracing in Idiopathic Scoliosis: A Scoping Review. PG - 100325 LID - 10.1016/j.jposna.2026.100325 [doi] LID - 100325 AB - BACKGROUND: The Providence nighttime brace (PNB) is an emerging conservative treatment modality in adolescent idiopathic scoliosis (AIS). The purpose of this study was to map the extent and nature of published evidence on the PNB, to summarize outcomes and patient-reported effects, and to identify gaps for future investigation. METHODS: This study followed Joanna Briggs Institute methodology and was reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews (PRISMA-ScR) guidelines. A keyword search was queried in PubMed, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science Core Collection, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and Scopus databases. Included studies were original articles focused on PNB utilization in AIS treatment. Non-peer-reviewed, opinion, editorial, or review articles were excluded. RESULTS: A total of 24 studies were included, encompassing 2,262 patients. Six studies compared outcomes to full-time orthoses; eleven examined ways to improve PNB success; three evaluated the PNB's impact on quality of life. The literature suggests the PNB consistently prevents curve progression in indicated patients, especially in curves measuring <35 degrees and those with an apex at or below T9. Most comparative studies report that the PNB achieves similar outcomes to full-time orthoses when patients are appropriately selected. However, differences in study design, patient selection, and outcome definitions limit firm conclusions. The PNB was generally reported to have a manageable impact on quality of life. Innovations such as ultrasound custom fitting, predictive models, and temperature sensors may improve brace fit, adherence, and outcomes. CONCLUSIONS: The literature identifies the Providence brace as a viable, patient-compliant treatment in mild to moderate AIS. While the PNB shows promise, variability in study design and indications underscores the need for prospective, randomized studies. Researchers should use Scoliosis Research Society criteria for inclusion and assessment, as well as objective compliance measures when feasible. Continued innovation with predictive models, custom brace-fitting, and temperature sensors may further improve outcomes. KEY CONCEPTS: (1)The Providence nighttime brace (PNB) effectively prevents curve progression in adolescent idiopathic scoliosis (AIS), especially in lumbar or thoracolumbar curves measuring <35 degrees .(2)Most comparative studies suggest the PNB achieves similar outcomes to full-time orthoses in appropriately selected patients, but heterogeneity in study design, patient selection, and outcome definitions limits firm conclusions.(3)Preliminary evidence suggests the PNB may offer an acceptable quality of life profile, although current data are limited and further comparative studies using validated instruments are needed.(4)Prospective studies using Scoliosis Research Society criteria with standardized outcomes, predefined subgroups, and objective compliance measures are needed to solidify indications and patient education.(5)Predictive models, custom brace-fitting, objective compliance monitoring, and adjunctive physiotherapeutic exercises are promising innovations for improving PNB outcomes. LEVEL OF EVIDENCE: V. CI - (c) 2026 The Author(s). FAU - Kodra, Jacob D AU - Kodra JD AD - Department of Orthopaedic Surgery, Children's Wisconsin, Medical College of Wisconsin, Milwaukee, WI, USA. FAU - Bollepalli, Harshavardhan AU - Bollepalli H AD - Department of Orthopaedic Surgery, Children's Wisconsin, Medical College of Wisconsin, Milwaukee, WI, USA. FAU - White, Carter J K AU - White CJK AD - Department of Orthopaedic Surgery, Children's Wisconsin, Medical College of Wisconsin, Milwaukee, WI, USA. FAU - Thometz, John G AU - Thometz JG AD - Department of Orthopaedic Surgery, Children's Wisconsin, Medical College of Wisconsin, Milwaukee, WI, USA. FAU - Liu, Xue-Cheng AU - Liu XC AD - Department of Orthopaedic Surgery, Children's Wisconsin, Medical College of Wisconsin, Milwaukee, WI, USA. LA - eng PT - Journal Article PT - Review DEP - 20260129 PL - United States TA - J Pediatr Soc North Am JT - Journal of the Pediatric Orthopaedic Society of North America JID - 101776896 PMC - PMC13054609 OTO - NOTNLM OT - Bracing OT - Providence OT - Providence bracing OT - Scoliosis OT - Spine COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/09 06:30 MHDA- 2026/04/09 06:31 PMCR- 2026/01/29 CRDT- 2026/04/09 04:37 PHST- 2025/11/05 00:00 [received] PHST- 2025/12/29 00:00 [revised] PHST- 2025/12/29 00:00 [accepted] PHST- 2026/04/09 06:31 [medline] PHST- 2026/04/09 06:30 [pubmed] PHST- 2026/04/09 04:37 [entrez] PHST- 2026/01/29 00:00 [pmc-release] AID - S2768-2765(26)00004-0 [pii] AID - 100325 [pii] AID - 10.1016/j.jposna.2026.100325 [doi] PST - epublish SO - J Pediatr Soc North Am. 2026 Jan 29;15:100325. doi: 10.1016/j.jposna.2026.100325. eCollection 2026 May. PMID- 41951412 OWN - NLM STAT- Publisher LR - 20260408 IS - 1349-7235 (Electronic) IS - 0918-2918 (Linking) DP - 2026 Apr 7 TI - A Phase Angle Used as a Screening Tool for Malnutrition in Japanese Patients with Liver Cirrhosis. LID - 10.2169/internalmedicine.6677-25 [doi] AB - Objective Malnutrition and sarcopenia are associated with poor clinical outcomes in patients with cirrhosis. While the Phase angle (PhA) is a promising marker, validated ethnicity-specific cutoff values for Asian populations, who often show different body composition profiles, are lacking. This study aimed to establish and validate PhA cutoff values for diagnosing malnutrition and sarcopenia in a Japanese cohort. Methods We retrospectively analyzed 337 Japanese patients with liver cirrhosis who were randomly assigned to training (n=235) and validation (n=102) groups. Optimal sex-specific PhA cutoff values were then determined to identify malnutrition and sarcopenia. Overall survival was compared to assess the prognostic value of PhA. Results PhA was positively correlated with the body mass index, albumin level, and other nutritional indices (all p<0.05). A lower PhA was associated with a poorer hepatic reserve, as indicated by the Child-Pugh and mALBI grades (p<0.001). A multivariate analysis identified the PhA as an independent predictor of malnutrition and sarcopenia (p<0.01). Patients in the low PhA group had a shorter overall survival (p=0.024). The optimal PhA cut-off values for malnutrition and sarcopenia were 4.8 for males and 4.2 for females (AUROCs:0.70-0.76). In the validation cohort, the PhA cutoff values showed good sensitivity (76.7%) and a negative predictive value (75.0%) for malnutrition. Conclusion We established and validated the first sex-specific PhA cutoff values for malnutrition in Japanese patients with cirrhosis, which were lower than those in Western populations. PhA independently predicts malnutrition, sarcopenia, and overall survival, thereby offering clinicians a simple, noninvasive screening tool to enhance nutritional assessment in routine practice. FAU - Haraguchi, Masafumi AU - Haraguchi M AD - Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Japan. FAU - Miuma, Satoshi AU - Miuma S AD - Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Japan. FAU - Nakao, Yasuhiko AU - Nakao Y AD - Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Japan. FAU - Fukushima, Masanori AU - Fukushima M AD - Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Japan. FAU - Sasaki, Ryu AU - Sasaki R AD - Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Japan. FAU - Takahata, Hideaki AU - Takahata H AD - Department of Rehabilitation Medicine, Nagasaki University Hospital, Japan. FAU - Miyaaki, Hisamitsu AU - Miyaaki H AD - Department of Gastroenterology and Hepatology, Nagasaki University Graduate School of Biomedical Sciences, Japan. LA - eng PT - Journal Article DEP - 20260407 PL - Japan TA - Intern Med JT - Internal medicine (Tokyo, Japan) JID - 9204241 SB - IM OTO - NOTNLM OT - Bioelectrical Impedance OT - Body Composition OT - Hand Strength OT - Liver Cirrhosis OT - Muscle Strength OT - Nutritional Status EDAT- 2026/04/09 00:33 MHDA- 2026/04/09 00:33 CRDT- 2026/04/08 21:33 PHST- 2026/04/09 00:33 [medline] PHST- 2026/04/09 00:33 [pubmed] PHST- 2026/04/08 21:33 [entrez] AID - 10.2169/internalmedicine.6677-25 [doi] PST - aheadofprint SO - Intern Med. 2026 Apr 7. doi: 10.2169/internalmedicine.6677-25. PMID- 41950074 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1984-0462 (Electronic) IS - 0103-0582 (Print) IS - 0103-0582 (Linking) VI - 44 DP - 2026 TI - NutriRisKids-ICU: Development and content validation of a nutritional risk screening tool for critically ill children and adolescents. PG - e2025246 LID - S0103-05822026000101009 [pii] LID - 10.1590/1984-0462/2026/44/2025246 [doi] LID - e2025246 AB - OBJECTIVE: The aim of this study was to develop and validate the content of a nutritional risk screening tool for critically ill children and adolescents in pediatric intensive care units (PICUs). METHODS: Care-convergent study for the development and content validation of an instrument for assessing nutritional risk in children admitted to the PICU. The initial development was based on a literature review and the clinical experience of the authors. Content validation was conducted using the Delphi technique in two successive rounds with intentionally selected experts, each with a minimum of 5 years of experience in pediatric intensive nutritional therapy (NT). Consensus analysis was performed using the content validity index (CVI), with minimum values of 0.70 for individual items and 0.90 for the overall instrument. RESULTS: Validation occurred in two rounds. In the first round, 18 experts suggested adjustments, and the revised version was reassessed by 12 experts in the second round. The final tool achieved an overall CVI of 0.958. The validated version included age subgroups, presence of chronic diseases, length of prior hospitalization, subjective impression of malnutrition risk, type of NT at admission, and C-reactive protein (CRP) levels. CONCLUSIONS: The nutritional risk screening tool for critically ill pediatric patients, named NutriRisKids-ICU, was developed, and its content was validated by expert consensus. The tool combines theoretical evidence and clinical expertise, showing potential for application in PICUs. However, further studies are needed to assess its applicability, sensitivity, and specificity. FAU - Souza, Veronica Ramos AU - Souza VR AUID- ORCID: 0009-0004-2023-7758 AD - Universidade de Sao Paulo - Sao Paulo, SP, Brazil. FAU - Trida, Vanessa Camargo AU - Trida VC AUID- ORCID: 0000-0002-7452-2472 AD - Universidade de Sao Paulo - Sao Paulo, SP, Brazil. FAU - Mazzoni, Beatriz Polisel AU - Mazzoni BP AUID- ORCID: 0000-0001-6333-5359 AD - Universidade de Sao Paulo - Sao Paulo, SP, Brazil. FAU - Gandolfo, Adriana Servilha AU - Gandolfo AS AUID- ORCID: 0000-0001-5416-6733 AD - Universidade de Sao Paulo - Sao Paulo, SP, Brazil. FAU - de Carvalho, Werther Brunow AU - de Carvalho WB AUID- ORCID: 0000-0002-9164-616X AD - Universidade de Sao Paulo - Sao Paulo, SP, Brazil. FAU - Delgado, Artur Figueiredo AU - Delgado AF AUID- ORCID: 0000-0003-4362-9880 AD - Universidade de Sao Paulo - Sao Paulo, SP, Brazil. FAU - Zamberlan, Patricia AU - Zamberlan P AUID- ORCID: 0000-0003-4118-9965 AD - Universidade de Sao Paulo - Sao Paulo, SP, Brazil. LA - eng PT - Journal Article PT - Validation Study DEP - 20260403 PL - Brazil TA - Rev Paul Pediatr JT - Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo JID - 9109353 SB - IM MH - Humans MH - *Critical Illness MH - Intensive Care Units, Pediatric MH - Adolescent MH - Child MH - *Nutrition Assessment MH - Risk Assessment/methods MH - Female MH - Male MH - *Malnutrition/diagnosis PMC - PMC13053041 EDAT- 2026/04/08 18:32 MHDA- 2026/04/08 18:33 PMCR- 2026/04/03 CRDT- 2026/04/08 13:13 PHST- 2025/09/01 00:00 [received] PHST- 2025/11/16 00:00 [accepted] PHST- 2026/04/08 18:33 [medline] PHST- 2026/04/08 18:32 [pubmed] PHST- 2026/04/08 13:13 [entrez] PHST- 2026/04/03 00:00 [pmc-release] AID - S0103-05822026000101009 [pii] AID - 10.1590/1984-0462/2026/44/2025246 [doi] PST - epublish SO - Rev Paul Pediatr. 2026 Apr 3;44:e2025246. doi: 10.1590/1984-0462/2026/44/2025246. eCollection 2026. PMID- 41949981 OWN - NLM STAT- MEDLINE DCOM- 20260702 LR - 20260702 IS - 1558-9129 (Electronic) IS - 0161-1461 (Linking) VI - 57 IP - 3 DP - 2026 Jul 2 TI - Development and Preliminary Outcomes of a Parent-Led Intervention for Malaysian School-Age Children With Cleft Lip and/or Palate. PG - 743-759 LID - 10.1044/2026_LSHSS-25-00133 [doi] AB - PURPOSE: Children with cleft lip and/or palate (CL/P) face psychosocial and communication challenges that may hinder peer relationships and emotional well-being. This study aimed to develop and evaluate the preliminary outcomes of the Module Klefiden, a parent-led intervention designed to improve psychosocial and communication functioning in Malaysian school-age children with CL/P. METHOD: Module activities were developed through the Nominal Group Technique (n = 12) and validated by an expert panel (n = 8). The module was then evaluated through a feasibility study with 10 parents, followed by preliminary outcomes involving 17 children. RESULTS: The Module Klefiden comprises 14 culturally tailored, strength-based activities addressing stigma, teasing, and resilience building. The content validity of the module was high (0.86). The feasibility study showed that most parents found the Module Klefiden practicable and acceptable, as indicated by the results of the Treatment Evaluation Inventory-Short Form (M = 37.08). In the preliminary outcomes study, the module was evaluated before and after the intervention in four domains of the Cleft Lip and/or Palate Questionnaire (CLEFT-Q). The experimental group showed significant improvements in psychological function (Z = -2.668, p = .008, r = .889) and speech distress (Z = -2.201, p = .028, r = .734). Both groups showed improvements in social participation (experimental: Z = -2.392, p = .017, r = .797; control: Z = -2.375, p = .018, r = .840). Qualitative data highlighted the children's increased confidence in discussing their cleft condition. At school, children still favored physical activities over speech-related tasks. CONCLUSIONS: The Module Klefiden shows promise in improving psychosocial and communication outcomes in children with CL/P. Its structured, parent-led approach fosters emotional resilience and self-assurance, addressing a critical gap in cleft care in Malaysia. Future research should explore its long-term, large-scale application. SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.31894306. FAU - Yusof, Safwan AU - Yusof S AUID- ORCID: 0000-0002-3692-5406 AD - Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur. FAU - Mohd Ibrahim, Hasherah AU - Mohd Ibrahim H AUID- ORCID: 0000-0002-9383-7541 AD - Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur. FAU - Bressmann, Tim AU - Bressmann T AUID- ORCID: 0000-0001-5675-0490 AD - Department of Speech-Language Pathology, University of Toronto, Ontario, Canada. LA - eng PT - Journal Article DEP - 20260408 PL - United States TA - Lang Speech Hear Serv Sch JT - Language, speech, and hearing services in schools JID - 0323431 SB - IM MH - Humans MH - *Cleft Lip/psychology/therapy MH - *Cleft Palate/psychology/therapy MH - Child MH - Female MH - Malaysia MH - Male MH - *Parents/psychology MH - Feasibility Studies MH - Surveys and Questionnaires EDAT- 2026/04/08 18:32 MHDA- 2026/07/02 12:34 CRDT- 2026/04/08 12:13 PHST- 2026/07/02 12:34 [medline] PHST- 2026/04/08 18:32 [pubmed] PHST- 2026/04/08 12:13 [entrez] AID - 10.1044/2026_LSHSS-25-00133 [doi] PST - ppublish SO - Lang Speech Hear Serv Sch. 2026 Jul 2;57(3):743-759. doi: 10.1044/2026_LSHSS-25-00133. Epub 2026 Apr 8. PMID- 41949745 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1590-9999 (Electronic) IS - 1590-9921 (Print) IS - 1590-9921 (Linking) VI - 27 IP - 1 DP - 2026 Apr 8 TI - Updating radiographic parameters for the healthy growing hip: are current parameters still valid? LID - 10.1186/s10195-026-00917-7 [doi] LID - 26 AB - BACKGROUND: This study aimed to evaluate whether the acetabular angle (AA) by Tonnis and lateral center-edge angle (LCEA) by Wiberg-key radiographic parameters in pediatric hip assessment-have changed in a contemporary pediatric population compared with historical reference values, considering trends in earlier skeletal maturation and body composition. MATERIALS AND METHODS: This retrospective diagnostic accuracy study assessed changes in AA and center-edge angle (CE) angles in a contemporary cohort. A total of 1774 anteroposterior pelvic radiographs (3548 hips) from patients aged 0-18 years without hip pathology were analyzed. Radiographs were obtained between 2006 and 2018 and measured using the Supervisely digital platform. Standardized anatomical landmarks were applied. Data were stratified by age and sex and compared with historical values using two-sample t-tests (p < 0.05). To minimize measurement bias, two independent observers conducted all assessments using standardized digital protocols. RESULTS: A total of 1774 patients aged 0-18 years (mean age, 8.30 +/- 5.20 years; 666 females, 1108 males) were evaluated. AA values did not show statistically significant differences in 11 of 16 age groups compared with historical data (p > 0.05). In contrast, LCEAs were significantly higher in the contemporary cohort, especially in the 5-8, 9-12, and 12-16 age groups (all p < 0.01), indicating a trend toward earlier or increased acetabular ossification and femoral head coverage. CONCLUSIONS: LCEA values were significantly higher in the contemporary pediatric cohort compared with historical data, while AA values remained stable across most age groups. These findings suggest that current radiographic reference standards for LCEA may warrant reassessment to ensure accurate dysplasia assessment. LEVEL OF EVIDENCE: level 3 (diagnosis). CI - (c) 2026. The Author(s). FAU - Hutter, Konstanze AU - Hutter K AD - Department of Orthopedics and Trauma, Medical University of Graz, Auenbruggerplatz 5, 8036, Graz, Austria. FAU - Smolle, Maria Anna AU - Smolle MA AD - Department of Orthopedics and Trauma, Medical University of Graz, Auenbruggerplatz 5, 8036, Graz, Austria. mariaanna.smolle@uniklinikum.kages.at. FAU - Butter, Sophie AU - Butter S AD - Department of Orthopedics and Trauma, Medical University of Graz, Auenbruggerplatz 5, 8036, Graz, Austria. FAU - Schroedter, Rene AU - Schroedter R AD - Department of Orthopedics and Trauma, Medical University of Graz, Auenbruggerplatz 5, 8036, Graz, Austria. FAU - Tschauner, Sebastian AU - Tschauner S AD - Division of Pediatric Radiology, Medical University of Graz, Graz, Austria. FAU - Kraus, Tanja AU - Kraus T AD - Department of Orthopedics and Trauma, Medical University of Graz, Auenbruggerplatz 5, 8036, Graz, Austria. LA - eng PT - Journal Article DEP - 20260408 PL - Italy TA - J Orthop Traumatol JT - Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology JID - 101090931 SB - IM MH - Humans MH - Female MH - Male MH - Child, Preschool MH - Child MH - Adolescent MH - Infant MH - Retrospective Studies MH - Reference Values MH - Infant, Newborn MH - Radiography MH - *Hip Joint/diagnostic imaging/growth & development MH - *Acetabulum/diagnostic imaging/growth & development PMC - PMC13219683 OTO - NOTNLM OT - Acetabular angle OT - Lateral center-edge angle OT - Pediatric hip OT - Radiographic parameters OT - Reference values OT - Skeletal maturation COIS- Declarations. Ethics approval and consent to participate: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the local ethics committee (ethics committee no. 32-116 ex 19/20). Consent for publication: Not applicable; informed consent was waived by the local institutional review board owing to the retrospective design. No individual person's data in any identifiable form are included in this manuscript. Competing interests: The authors have no relevant financial or nonfinancial interests to disclose. EDAT- 2026/04/08 12:35 MHDA- 2026/05/29 15:46 PMCR- 2026/04/08 CRDT- 2026/04/08 11:08 PHST- 2025/12/04 00:00 [received] PHST- 2026/03/08 00:00 [accepted] PHST- 2026/05/29 15:46 [medline] PHST- 2026/04/08 12:35 [pubmed] PHST- 2026/04/08 11:08 [entrez] PHST- 2026/04/08 00:00 [pmc-release] AID - 10.1186/s10195-026-00917-7 [pii] AID - 917 [pii] AID - 10.1186/s10195-026-00917-7 [doi] PST - epublish SO - J Orthop Traumatol. 2026 Apr 8;27(1):26. doi: 10.1186/s10195-026-00917-7. PMID- 41949461 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260903 IS - 2473-9537 (Electronic) IS - 2473-9529 (Print) IS - 2473-9529 (Linking) VI - 10 IP - 12 DP - 2026 Jun 23 TI - ASH/ISTH 2026 guidelines for anticoagulant prophylaxis in pediatric patients at risk of venous thromboembolism. PG - 4303-4333 LID - 10.1182/bloodadvances.2025019415 [doi] AB - High-quality data on anticoagulant prophylaxis for pediatric VTE prevention are scarce. Key research priorities include the development and validation of subgroups-specific VTE risk assessment models, and evaluation of the safety and efficacy of risk-stratified anticoagulant prophylaxis strategies across different pediatric subgroups. BACKGROUND: Venous thromboembolism (VTE) is a significant cause of morbidity in children, particularly among hospitalized patients and those with chronic medical conditions. There is a lack of consensus on anticoagulant prophylaxis strategies. OBJECTIVE: These evidence-based guidelines from the American Society of Hematology (ASH) and the International Society on Thrombosis and Haemostasis (ISTH) are intended to support patients and health care professionals in decisions about anticoagulant prophylaxis for pediatric VTE prevention. METHODS: ASH formed a multidisciplinary guideline panel that included 1 patient representative. The University of Kansas Health System supported the guideline development process, including systematic evidence reviews up to April 2025. Clinical questions and outcomes were prioritized according to their importance for clinicians and patients. The panel used the GRADE (Grading of Recommendations Assessment, Development, and Evaluation) approach to assess certainty in the evidence and make recommendations. RESULTS: The panel agreed on 12 recommendations. For pediatric patients with solid cancer, who have experienced trauma, or who are critically ill, the panel issued conditional recommendations suggesting no anticoagulant prophylaxis. For pediatric patients with antiphospholipid antibody syndrome, or those on long-term total parenteral nutrition, the panel issued conditional recommendations suggesting the use of anticoagulant prophylaxis. Other pediatric subgroups addressed included patients with acute lymphoblastic leukemia or lymphoma, surgical and hospitalized patients, and those with a central venous access device. CONCLUSIONS: High-quality data on anticoagulant prophylaxis for pediatric VTE prevention are scarce. Key research priorities include the development and validation of subgroups-specific VTE risk assessment models, and evaluation of the safety and efficacy of risk-stratified anticoagulant prophylaxis strategies across different pediatric subgroups. CI - (c) 2026 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved. FAU - Betensky, Marisol AU - Betensky M AUID- ORCID: 0000-0001-6725-3035 AD - Division of Hematology, Department of Pediatrics, Johns Hopkins School of Medicine, Baltimore, MD. AD - Division of Hematology, Cancer and Blood Disorders Institute, Johns Hopkins All Children's Hospital, St. Petersburg, FL. FAU - Azzam, Muayad AU - Azzam M AUID- ORCID: 0000-0002-2046-8343 AD - Evidence-Based Practice and Impact Center, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS. FAU - Bercovitz, Rachel AU - Bercovitz R AUID- ORCID: 0000-0001-6653-5946 AD - Division of Hematology, Oncology and Stem Cell Transplantation, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL. FAU - Bhat, Rukhmi V AU - Bhat RV AUID- ORCID: 0000-0002-1700-4804 AD - Division of Hematology, Oncology and Stem Cell Transplantation, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL. FAU - Biss, Tina AU - Biss T AUID- ORCID: 0000-0001-9986-4973 AD - Department of Haematology, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, United Kingdom. FAU - Branchford, Brian AU - Branchford B AUID- ORCID: 0000-0002-4076-270X AD - Division of Hematology, Department of Pediatrics, Medical College of Wisconsin, Wauwatosa, WI. FAU - Brandao, Leonardo R AU - Brandao LR AUID- ORCID: 0000-0001-7711-4530 AD - Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada. FAU - Chan, Anthony K C AU - Chan AKC AUID- ORCID: 0000-0003-1551-3995 AD - Division Pediatric Hematology/Oncology, Department of Pediatrics, McMaster Children's Hospital, McMaster University, Hamilton, ON, Canada. FAU - Faustino, E Vincent S AU - Faustino EVS AUID- ORCID: 0000-0001-6155-2691 AD - Department of Pediatrics, Section of Critical Care, Yale School of Medicine, New Haven, CT. FAU - Hamarsha, Qais AU - Hamarsha Q AUID- ORCID: 0000-0001-9711-4650 AD - Evidence-Based Practice and Impact Center, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS. FAU - Jaffray, Julie AU - Jaffray J AUID- ORCID: 0000-0002-1175-7266 AD - Division of Hematology/Oncology, Department of Pediatrics, Rady Children's Hospital-San Diego, San Diego, CA. FAU - Jones, Sophie AU - Jones S AUID- ORCID: 0000-0002-9272-6540 AD - Faculty of Medicine, Dentistry and Health Sciences, Department of Nursing, Royal Children's Hospital, University of Melbourne, Melbourne, VIC, Australia. FAU - Kawtharany, Hassan AU - Kawtharany H AUID- ORCID: 0009-0007-3725-8485 AD - Evidence-Based Practice and Impact Center, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS. FAU - Kerlin, Bryce A AU - Kerlin BA AUID- ORCID: 0000-0002-1756-8271 AD - Division of Pediatric Hematology/Oncology/BMT, Department of Pediatrics, Nationwide Children's Hospital, The Ohio State University College of Medicine, Columbus, OH. FAU - Khawandi, Jana AU - Khawandi J AUID- ORCID: 0000-0001-7581-4787 AD - Evidence-Based Practice and Impact Center, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS. FAU - Krider, Grace AU - Krider G AD - Department of Nursing, Ascension St. Vincent Indianapolis, Indianapolis, IN. FAU - Kucine, Nicole AU - Kucine N AUID- ORCID: 0000-0002-4865-4033 AD - Division of Hematology/Oncology, Department of Pediatrics, Weill Cornell Medicine, New York, NY. FAU - Kumar, Riten AU - Kumar R AUID- ORCID: 0000-0001-8004-4190 AD - Department of Pediatrics, Dana Farber/Boston Children's Cancer and Blood Disorders Center, Harvard Medical School, Boston, MA. FAU - Male, Christoph AU - Male C AUID- ORCID: 0000-0002-4989-6421 AD - Department of Paediatrics, Medical University of Vienna, Vienna, Austria. FAU - Monagle, Paul AU - Monagle P AUID- ORCID: 0000-0002-3970-8984 AD - Department of Pediatrics, Royal Children's Hospital, University of Melbourne, Melbourne, VIC, Australia. AD - Faculty of Medicine, Dentistry and Health Sciences, Sydney Children's Hospital, Randwick NSW, Australia. FAU - Pelland-Marcotte, Marie-Claude AU - Pelland-Marcotte MC AUID- ORCID: 0000-0003-2364-7205 AD - Department of Pediatrics, Centre Hospitalier Universitaire de Quebec, Centre Mere-Enfant, Quebec City, QC, Canada. FAU - Raffini, Leslie AU - Raffini L AUID- ORCID: 0000-0001-8152-1040 AD - Division of Hematology, Department of Pediatrics, University of Pennsylvania, Children's Hospital of Philadelphia, Philadelphia, PA. FAU - Raulji, Chittalsinh AU - Raulji C AUID- ORCID: 0009-0008-7610-7214 AD - Division of Hematology/Oncology, Department of Pediatrics, University of Nebraska Medical Center, Children's Hospital Nebraska, Omaha, NE. FAU - Sartain, Sarah E AU - Sartain SE AUID- ORCID: 0000-0003-2204-4568 AD - Section of Hematology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, TX. FAU - Takemoto, Clifford M AU - Takemoto CM AUID- ORCID: 0000-0002-2832-6884 AD - Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN. FAU - Tarango, Cristina AU - Tarango C AUID- ORCID: 0000-0002-0283-9972 AD - Division of Hematology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH. FAU - Heleen van Ommen, C AU - Heleen van Ommen C AUID- ORCID: 0000-0001-9036-039X AD - Department of Pediatric Hematology, Erasmus Medical Center Sophia Children's Hospital, Rotterdam, The Netherlands. FAU - Velez, Maria C AU - Velez MC AUID- ORCID: 0009-0006-9426-4075 AD - Division of Hematology/Oncology, Department of Pediatrics, Louisiana State University Health Sciences Center/Children's Hospital New Orleans, New Orleans, LA. FAU - Vesely, Sara K AU - Vesely SK AUID- ORCID: 0000-0003-3448-0156 AD - Department of Biostatistics and Epidemiology, University of Oklahoma Health Sciences, Hudson College of Public Health, Oklahoma City, OK. FAU - Wiernikowski, John AU - Wiernikowski J AUID- ORCID: 0000-0002-5058-3596 AD - Division of Hematology/Oncology, Department of Pediatrics, McMaster University, Hamilton, ON, Canada. FAU - Williams, Suzan AU - Williams S AUID- ORCID: 0000-0002-9321-4301 AD - Division of Hematology/Oncology, Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada. FAU - Wilson, Hope P AU - Wilson HP AUID- ORCID: 0000-0001-8904-3338 AD - Division of Hematology/Oncology, Department of Pediatrics, Children's of Alabama, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, AL. FAU - Woods, Gary AU - Woods G AUID- ORCID: 0000-0002-0921-0974 AD - Division of Hematology/Oncology, Department of Pediatrics, Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA. FAU - Mustafa, Reem A AU - Mustafa RA AUID- ORCID: 0000-0002-2091-0875 AD - Division of Nephrology, Department of Internal Medicine, Evidence-based Practice and Impact Center, The University of Kansas Health System, Kansas City, KS. LA - eng PT - Journal Article PT - Practice Guideline PL - United States TA - Blood Adv JT - Blood advances JID - 101698425 RN - 0 (Anticoagulants) SB - IM MH - Humans MH - *Venous Thromboembolism/prevention & control/etiology/drug therapy MH - *Anticoagulants/therapeutic use MH - Child MH - Risk Factors PMC - PMC13276589 COIS- Conflict-of-interest disclosure: All authors were members of the guideline panel or members of the systematic review team or both. As such, they completed a disclosure-of-interest form, which was reviewed by American Society of Hematology/International Society on Thrombosis and Haemostasis and is available as supplements 2 and 3. EDAT- 2026/04/08 12:34 MHDA- 2026/06/12 18:40 PMCR- 2026/04/08 CRDT- 2026/04/08 10:03 PHST- 2026/02/18 00:00 [accepted] PHST- 2025/12/16 00:00 [received] PHST- 2026/06/12 18:40 [medline] PHST- 2026/04/08 12:34 [pubmed] PHST- 2026/04/08 10:03 [entrez] PHST- 2026/04/08 00:00 [pmc-release] AID - 567385 [pii] AID - 10.1182/bloodadvances.2025019415 [doi] PST - ppublish SO - Blood Adv. 2026 Jun 23;10(12):4303-4333. doi: 10.1182/bloodadvances.2025019415. PMID- 41949007 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260714 IS - 1687-1634 (Electronic) IS - 1020-3397 (Linking) VI - 32 IP - 2 DP - 2026 Mar 5 TI - Smartphone addiction and motor-cognitive performance among adolescents in Tunisia. PG - 93-102 LID - 10.26719/2026.32.2.93 [doi] AB - BACKGROUND: Smartphone addiction among adolescents has emerged as a significant public health concern, with potential consequences for motor and cognitive development. AIM: To examine the associations between smartphone addiction and motor-cognitive performance among adolescents in Tunisia, using validated digital tools. METHODS: Between December 2023 and March 2024, we examined 270 students in 3 public middle schools in urban Tunisia. We assessed smartphone addiction using the validated Arabic version of the smartphone addiction scale short version; motor function using the Takei Grip‑D dynamometer, MySprint app and the Flamingo balance test; and cognitive function using the Vienna test system. Group comparisons were conducted using nonparametric tests; associations were examined using Spearman's correlations; and predictive effects were assessed using separate linear regression analyses adjusted for age, sex and body mass index (P > 0.05). RESULTS: Adolescents classified as addicted (n = 120) demonstrated significantly higher daily smartphone use (454.8 +/- 104.8 vs 172.1 +/- 108.6 minutes, P < 0.001), slower sprint time (6.09 +/- 0.70 vs 5.63 +/- 0.54 seconds, P < 0.001), reduced grip strength (22.3 +/- 3.5 vs 25.7 +/- 4.1 kg, P < 0.001), and lower cognitive accuracy despite faster reaction time (P < 0.01). Addiction severity independently predicted slower sprinting (beta = 0.32) and poorer postural stability (beta = 0.35, both P < 0.001). CONCLUSION: Smartphone addiction is linked to significant motor and cognitive impairment among adolescents in Tunisian schools, with addiction severity predicting slower sprinting and poorer postural stability. Early school-based interventions to promote healthy smartphone habits and physical activity may help prevent long-term motor-cognitive decline among adolescents in Tunisia. CI - Copyright (c) Authors 2026; Licensee: World Health Organization. EMHJ is an open-access journal. This paper is available under the Creative Commons Attribution Non-Commercial ShareAlike 3.0 IGO licence (CC BY-NC-SA 3.0 IGO; https://creativecommons.org/licenses/by-nc-sa/3.0/igo). FAU - Yaakoubi, Mohamed AU - Yaakoubi M AD - High Institute of Sports and Physical Education, University of Jendouba, Kef, Tunisia. AD - Research Unit, Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. FAU - Ghorbel, Ahmed AU - Ghorbel A AD - High Institute of Sports and Physical Education, University of Jendouba, Kef, Tunisia. AD - Research Unit, Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. FAU - Saddoud, Anis AU - Saddoud A AD - High Institute of Sports and Physical Education, University of Sfax, Sfax, Tunisia. FAU - Masmoudi, Liwa AU - Masmoudi L AD - Research Unit, Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. AD - High Institute of Sports and Physical Education, University of Sfax, Sfax, Tunisia. FAU - Trabelsi, Omar AU - Trabelsi O AD - High Institute of Sports and Physical Education, University of Jendouba, Kef, Tunisia. AD - Research Unit, Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. AD - High Institute of Applied Studies in Humanities, Department of Education Sciences, University of Monastir, Mahdia, Tunisia. FAU - Farhat, Faical AU - Farhat F AD - Research Unit, Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. AD - High Institute of Sports and Physical Education, University of Gafsa, Tunisia. AD - Faculty of Medicine, University of Sfax, Sfax, Tunisia. FAU - Gharbi, Adnene AU - Gharbi A AD - Research Unit, Physical Activity, Sport and Health, UR18JS01, National Observatory of Sport, Tunis, Tunisia. AD - High Institute of Sports and Physical Education, University of Sfax, Sfax, Tunisia. LA - eng PT - Journal Article DEP - 20260305 PL - Egypt TA - East Mediterr Health J JT - Eastern Mediterranean health journal = La revue de sante de la Mediterranee orientale = al-Majallah al-sihhiyah li-sharq al-mutawassit JID - 9608387 SB - IM MH - Humans MH - Tunisia/epidemiology MH - Adolescent MH - *Smartphone MH - Female MH - *Cognition MH - Male MH - *Internet Addiction Disorder/epidemiology MH - *Behavior, Addictive/epidemiology OTO - NOTNLM OT - Tunisia OT - adolescent health OT - cognitive function OT - motor skills OT - smartphone addiction EDAT- 2026/04/08 12:35 MHDA- 2026/04/08 12:36 CRDT- 2026/04/08 06:53 PHST- 2025/04/25 00:00 [received] PHST- 2025/09/30 00:00 [accepted] PHST- 2026/04/08 12:36 [medline] PHST- 2026/04/08 12:35 [pubmed] PHST- 2026/04/08 06:53 [entrez] AID - 10.26719/2026.32.2.93 [doi] PST - epublish SO - East Mediterr Health J. 2026 Mar 5;32(2):93-102. doi: 10.26719/2026.32.2.93. PMID- 41947516 OWN - NLM STAT- Publisher LR - 20260408 IS - 1544-0591 (Electronic) IS - 0022-0345 (Linking) DP - 2026 Apr 7 TI - Predicting Longitudinal Caries Trajectories from Childhood to Early Adulthood. PG - 220345261432531 LID - 10.1177/00220345261432531 [doi] AB - Prior studies have used traditional trajectory analyses to classify caries progression; however, none have applied machine learning (ML) to predict caries trajectories from childhood to early adulthood. The aims of our study are 1) to use unsupervised ML to perform trajectory analysis by clustering the longitudinal caries data into distinct trajectory groups and 2) to utilize supervised ML to predict trajectory group membership from behavioral/dietary, fluoride, and sociodemographic variables. This study was conducted using longitudinal data from 560 Iowa Fluoride Study participants. Trajectory analysis was first done via K-means for longitudinal data on caries data (D(2+)MFS counts) obtained at ages 9 y (n = 523), 13 y (n = 549), 17 y (n = 464), and 23 y (n = 342). The optimal number of trajectory groups was based on the Calinski-Harabasz criterion and clinical relevance. Supervised ML was then performed with trajectory group membership as the outcome variable against 11 predictor variables. The performance of 5 models was compared by Brier score and accuracy: 1) ordered multinomial logistic regression, 2) least absolute shrinkage and selection operation, 3) gradient boosting machine, 4) extreme gradient boosting, and 5) neural network. Of the 560 participants included in this study, 3 caries trajectory groups were identified: low (70.5%), medium (21.1%), and high (8.4%), characterized by minimal, moderate, and severe and progressive disease, respectively. Extreme gradient boosting outperformed the other 4 models, with 85.9% accuracy and a Brier score of 0.21. Top predictors included sex, socioeconomic status, home water fluoride concentration, fluoride intake from other sources, sugar-sweetened beverages, and 100% juice. This is the first study to combine ML models to predict caries trajectories from childhood to adulthood with high accuracy. Additional work is needed for validation using diverse clinical data. Predicting caries trajectories via ML could enable early identification of individuals at high risk and inform targeted, age-appropriate preventive interventions. FAU - Ogwo, C AU - Ogwo C AUID- ORCID: 0000-0002-9325-0126 AD - Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, MA, USA. FAU - Brown, G AU - Brown G AD - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA, USA. FAU - Warren, J AU - Warren J AD - Department of Preventive and Community Dentistry, College of Dentistry, University of Iowa, Iowa City, IA, USA. FAU - Okeagu, P AU - Okeagu P AD - Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, MA, USA. AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. FAU - Caplan, D AU - Caplan D AD - Department of Preventive and Community Dentistry, College of Dentistry, University of Iowa, Iowa City, IA, USA. FAU - Levy, S AU - Levy S AD - Department of Preventive and Community Dentistry, College of Dentistry, University of Iowa, Iowa City, IA, USA. AD - Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, USA. LA - eng PT - Journal Article DEP - 20260407 PL - United States TA - J Dent Res JT - Journal of dental research JID - 0354343 SB - IM OTO - NOTNLM OT - adolescent OT - artificial intelligence OT - cohort OT - machine learning OT - predictive modeling OT - tooth decay EDAT- 2026/04/08 06:33 MHDA- 2026/04/08 06:33 CRDT- 2026/04/08 02:13 PHST- 2026/04/08 06:33 [medline] PHST- 2026/04/08 06:33 [pubmed] PHST- 2026/04/08 02:13 [entrez] AID - 10.1177/00220345261432531 [doi] PST - aheadofprint SO - J Dent Res. 2026 Apr 7:220345261432531. doi: 10.1177/00220345261432531. PMID- 41947477 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Apr 8 TI - Beyond the clinic: sensory-adapted food services to support nutrition in autism spectrum disorder. PG - e81 LID - 10.1017/S1368980026102420 [doi] LID - e81 AB - Autism spectrum disorder (ASD) is a population-scale condition with life-course health consequences, yet nutrition support remains inconsistently embedded in routine pathways. Food selectivity is common in ASD and is associated with restricted dietary variety, nutritional imbalance, gastrointestinal morbidity and cardiometabolic vulnerability. Current responses are predominantly clinic-and family-centred and are difficult to scale equitably. This commentary argues that institutional food services (schools, day-care and residential settings) are an underused public health platform to improve inclusion and accountability through sensory-accessible, nutritionally adequate meals. Because these services are commissioned, standardised and audited, sensory accessibility can be operationalised via procurement specifications and quality indicators, enabling benchmarking across sites. Evidence from sensory-informed menu adaptation and implementation work suggests feasibility within routine operations and supports evaluation using system-relevant outcomes (acceptability, nutritional adequacy, waste, feasibility and maintenance). Three policy actions are proposed: embed sensory accessibility in institutional standards, integrate nutrition across sectors and fund scale-up using implementation science. FAU - Conti, Maria Vittoria AU - Conti MV AUID- ORCID: 0000-0002-8120-7091 AD - https://ror.org/00s6t1f81University of Pavia, Pavia, Italy. FAU - Fiechtner, Lauren AU - Fiechtner L AD - General Academic Pediatrics and Pediatric Gastroenterology, Mass General Hospital for Children, Boston, USA. FAU - Cena, Hellas AU - Cena H AUID- ORCID: 0000-0002-5752-6199 AD - https://ror.org/00s6t1f81University of Pavia, Pavia, Italy. AD - ICS Maugeri IRCCS, Pavia, Italy. LA - eng PT - Journal Article DEP - 20260408 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - *Autism Spectrum Disorder/diet therapy MH - *Food Services/standards MH - *Nutritional Support/methods MH - Child MH - Public Health PMC - PMC13087969 OTO - NOTNLM OT - Autism spectrum disorder OT - Food selectivity OT - Malnutrition OT - Nutrition OT - Public services COIS- H.C. declares no competing interests. L.F. declares no competing interests. M.V.C. declares no competing interests. EDAT- 2026/04/08 06:31 MHDA- 2026/04/08 06:32 PMCR- 2026/04/08 CRDT- 2026/04/08 01:52 PHST- 2026/04/08 06:32 [medline] PHST- 2026/04/08 06:31 [pubmed] PHST- 2026/04/08 01:52 [entrez] PHST- 2026/04/08 00:00 [pmc-release] AID - S1368980026102420 [pii] AID - 10.1017/S1368980026102420 [doi] PST - epublish SO - Public Health Nutr. 2026 Apr 8;29(1):e81. doi: 10.1017/S1368980026102420. PMID- 41947314 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1041-5505 (Print) IS - 2688-6855 (Electronic) IS - 1041-5505 (Linking) VI - 2026 IP - 236 DP - 2026 Feb TI - Traffic-Related Air Pollution and Birth Weight: The Roles of Noise, Placental Function, Green Space, Physical Activity, and Socioeconomic Status (FRONTIER). PG - 1-97 LID - 236 AB - INTRODUCTION: FRONTIER aimed to provide a robust and comprehensive evaluation of the impact of maternal exposure to traffic-related air pollution (TRAP) on fetal growth. Toward this aim it (1) disentangled the effects of noise as a co-exposure; (2) identified the relevant window(s) of vulnerability for this impact; (3) evaluated its modification by household and neighborhood level socioeconomic status (SES), stress, physical activity, and the timing of conception and delivery in relation to the COVID-19 pandemic lockdown; (4) elucidated the role of placental function as an underlying mechanism; and (5) explored the potential of urban tree canopies and green spaces to mitigate it. METHODS: FRONTIER established a new pregnancy cohort of 1,080 pregnant women in Barcelona, Spain - Barcelona Life Study Cohort (BiSC). Fetal growth was characterized by anthropometric measures at birth, together with ultrasound-based trajectories of fetal development. We developed an innovative exposure assessment framework integrating objective data on time-activity patterns with dispersion, land use regression, and hybrid models, with campaigns of personal and home-outdoor air pollution monitoring to estimate maternal exposure levels as well as inhaled dose of black carbon (BC), nitrogen dioxide (NO(2)), fine particulate matter (PM(2.5)), and PM(2.5) copper, iron, and zinc in the main microenvironments for pregnant women (home, workplace, and commuting routes). We also assessed maternal exposure to noise by integrating measurements at participants' homes and outdoors using noise monitors with modeled microenvironmental noise levels, data on noise sensitivity, annoyance, and protections against noise. We developed single- and multipollutant models to evaluate the impact of TRAP exposure and inhaled dose on fetal growth while also correcting for the exposure measurement error. We further evaluated the modification of associations by SES, stress (cortisol levels and perceived stress), physical activity (objective and subjective measures), their mitigation by urban greenness and canopy volume, and their mediation by Doppler ultrasound measures of placental function. RESULTS: We found that higher pregnancy exposure to NO(2), BC, PM(2.5), and PM(2.5) copper and iron contents, particularly at home and all microenvironments combined, were generally associated with lower birth weight, higher risk of small for gestational age (SGA), and a decelerated trajectory of fetal growth, although some of these associations were not statistically significant. These associations appeared to be stronger for mothers with higher SES and those with higher objective measures of psychological stress. For the COVID-19 pandemic and physical activity, as effect modifiers, and urban greenness and canopy cover, as effect mitigators, we observed mixed patterns. In multipollutant models that include different measures of exposure to noise in addition to TRAP, the associations between TRAP and fetal growth generally remained consistent with those that we observed in our main analyses. We found two potential windows of vulnerability for the association of TRAP with fetal growth: one at the end of the first trimester and the beginning of the second trimester, and another at the end of the third trimester. Finally, we observed that a small proportion of the associations between PM(2.5) and fetal growth could be mediated through the impact of these pollutants on placental function (i.e., umbilical artery pulsatility index). CONCLUSIONS: Exposure to TRAP is associated with impaired fetal growth. CI - (c) 2026 Health Effects Institute. All rights reserved. FAU - Dadvand, P AU - Dadvand P AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. FAU - Sunyer, J AU - Sunyer J AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. FAU - Rivas, I AU - Rivas I AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. FAU - Gomez-Roig, M D AU - Gomez-Roig MD AD - Hospital de Sant Joan de Deu, Barcelona, Spain. FAU - Llurba, E AU - Llurba E AD - Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. FAU - Foraster, M AU - Foraster M AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. FAU - Arevalo, G AU - Arevalo G AD - Air Quality and Energy Efficiency Department, Barcelona Regional, Barcelona, Spain. FAU - Barril, L AU - Barril L AD - Barcelona Regional, Barcelona, Spain. FAU - Bustamante, M AU - Bustamante M AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. FAU - Basagana, X AU - Basagana X AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. FAU - Cirach, M AU - Cirach M AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. FAU - Dominguez, A AU - Dominguez A AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. FAU - Galmes, T AU - Galmes T AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. FAU - Gascon, M AU - Gascon M AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. FAU - Lao, J AU - Lao J AD - Air Quality and Energy Efficiency Department, Barcelona Regional, Barcelona, Spain. FAU - Gallego, E M AU - Gallego EM AD - Hospital de Sant Joan de Deu, Barcelona, Spain. FAU - Moreno, T AU - Moreno T AD - Institute of Environmental Assessment and Water Research, Barcelona, Spain. FAU - Nieuwenhuijsen, M J AU - Nieuwenhuijsen MJ AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. FAU - Persavento, C AU - Persavento C AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. FAU - Raimbault, B AU - Raimbault B AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. FAU - Querol, X AU - Querol X AD - Institute of Environmental Assessment and Water Research, Barcelona, Spain. FAU - Tonne, C AU - Tonne C AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. LA - eng PT - Journal Article PL - United States TA - Res Rep Health Eff Inst JT - Research report (Health Effects Institute) JID - 8812230 RN - 0 (Air Pollutants) RN - 0 (Vehicle Emissions) RN - 0 (Particulate Matter) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Birth Weight MH - *Traffic-Related Pollution/adverse effects/analysis MH - Spain/epidemiology MH - *Maternal Exposure/adverse effects/statistics & numerical data MH - *Exercise MH - Adult MH - *Placenta/physiology MH - *Noise/adverse effects MH - Fetal Development MH - Social Class MH - *Air Pollution/adverse effects/analysis MH - COVID-19/epidemiology MH - Cohort Studies MH - Infant, Newborn MH - Air Pollutants/analysis/adverse effects MH - *Vehicle Emissions/analysis MH - Particulate Matter/analysis MH - Socioeconomic Disparities in Health PMC - PMC13057358 EDAT- 2026/04/08 06:32 MHDA- 2026/04/08 06:33 PMCR- 2026/02/01 CRDT- 2026/04/08 00:23 PHST- 2026/04/08 06:33 [medline] PHST- 2026/04/08 06:32 [pubmed] PHST- 2026/04/08 00:23 [entrez] PHST- 2026/02/01 00:00 [pmc-release] AID - hei-2026-236 [pii] PST - ppublish SO - Res Rep Health Eff Inst. 2026 Feb;2026(236):1-97. PMID- 41947098 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Apr 7 TI - Associations between digital healthy diet literacy, artificial intelligence attitudes, mediterranean diet adherence, and health-related quality of life in adults. LID - 10.1186/s12889-026-27238-y [doi] LID - 1598 AB - OBJECTIVE: In the digital age, the ability to critically evaluate online nutritional information is of paramount importance. This study aimed to examine the relationships between digital healthy diet literacy (DHDL), attitudes towards artificial intelligence (AI), adherence to the Mediterranean Diet (MD), and the physical and mental components of health-related quality of life in adults. METHODS: This cross-sectional study was conducted in Ankara, Turkey, using snowball sampling and a web-based questionnaire; 1240 adults (740 women, 500 men) aged 18-65 were included in the study. Data were collected through a web-based questionnaire that included demographic information, self-reported anthropometric measurements, and validated scales. The scales used include: Digital Eating Literacy Scale, Attitudes toward Artificial Intelligence Scale, Short Form-12 Quality of Life Scale (SF-12), and Mediterranean Diet Adherence Scale (MEDAS). RESULTS: DHDL scores showed significant positive correlations with AI attitude scores (r = 0.195), the physical (r = 0.218) and mental (r = 0.291) components of health-related quality of life, and MD adherence (r = 0.206) (p < 0.001 for all). Similarly, higher attitudes toward AI were significantly associated with better MD adherence (r = 0.250) and higher physical (r = 0.138) and mental (r = 0.129) quality of life. Linear regression analyses indicated that demographic and socioeconomic factors such as gender, age, marital status, education and income level, and employment status were significant predictors of digital healthy diet literacy (DHDL), AI attitudes, Physical Component Summary-12 (PCS-12), Mental Component Summary-12 (MCS-12), and MEDAS scores (p < 0.05). CONCLUSIONS: High DHDL levels, positive attitudes toward AI, and high adherence with MD are interrelated and positively correlated with better health-related quality of life. In public health strategies, incorporating holistic interventions that improve DHDL, encourage positive interaction with AI-based health tools, and support adherence to evidence-based dietary patterns such as the MD may contribute to improved overall well-being. FAU - Guler, Ummugulsum AU - Guler U AUID- ORCID: 0009-0001-3352-6047 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkiye, Turkey. FAU - Mengi̇ Celi̇k, Ozge AU - Mengi̇ Celi̇k O AUID- ORCID: 0000-0002-0298-9591 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Faculty, University of Health Sciences, Ankara, Turkiye, Turkey. ozgeemengi@gmail.com. FAU - Baspinar, Emine Nefise AU - Baspinar EN AUID- ORCID: 0009-0007-5073-0959 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkiye, Turkey. FAU - Degi̇rmenci̇oglu, Elif AU - Degi̇rmenci̇oglu E AUID- ORCID: 0009-0005-5332-8493 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkiye, Turkey. FAU - Eser, Binnaz AU - Eser B AUID- ORCID: 0009-0007-7584-6763 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkiye, Turkey. FAU - Serenli̇oglu, Dila AU - Serenli̇oglu D AUID- ORCID: 0009-0000-0056-7224 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkiye, Turkey. FAU - Kilic, Gulnur AU - Kilic G AUID- ORCID: 0009-0004-6413-1074 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkiye, Turkey. FAU - Gencoglu, Irem AU - Gencoglu I AUID- ORCID: 0009-0009-9426-2135 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkiye, Turkey. FAU - Kaya, Melike AU - Kaya M AUID- ORCID: 0009-0007-6212-2985 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkiye, Turkey. FAU - Sariteke, Yaprak AU - Sariteke Y AUID- ORCID: 0009-0002-9007-6633 AD - Department of Nutrition and Dietetics, Gulhane Health Sciences Institute, University of Health Sciences, Ankara, Turkiye, Turkey. LA - eng PT - Journal Article DEP - 20260407 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - *Quality of Life/psychology MH - Adult MH - Male MH - *Diet, Mediterranean/statistics & numerical data/psychology MH - Middle Aged MH - Cross-Sectional Studies MH - Adolescent MH - *Health Literacy/statistics & numerical data MH - Young Adult MH - *Artificial Intelligence/statistics & numerical data MH - *Diet, Healthy/statistics & numerical data/psychology MH - Aged MH - Turkey MH - Surveys and Questionnaires MH - Digital Media MH - Digital Health MH - *Patient Compliance/statistics & numerical data PMC - PMC13192162 OTO - NOTNLM OT - Artificial intelligence OT - Digital health diet literacy OT - Health-related quality of life OT - Mediterranean diet COIS- Declarations. Ethics approval and consent to participate: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was conducted with the approval of the University of Health Sciences Gulhane Scientific Research Ethics Committee, numbered 2025/535. Informed consent was obtained from all participants included in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/08 00:30 MHDA- 2026/06/27 18:38 PMCR- 2026/04/07 CRDT- 2026/04/07 23:58 PHST- 2026/01/15 00:00 [received] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/06/27 18:38 [medline] PHST- 2026/04/08 00:30 [pubmed] PHST- 2026/04/07 23:58 [entrez] PHST- 2026/04/07 00:00 [pmc-release] AID - 10.1186/s12889-026-27238-y [pii] AID - 27238 [pii] AID - 10.1186/s12889-026-27238-y [doi] PST - epublish SO - BMC Public Health. 2026 Apr 7;26(1):1598. doi: 10.1186/s12889-026-27238-y. PMID- 41946834 OWN - NLM STAT- Publisher LR - 20260515 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Apr 7 TI - Early enteral nutrition practices and their association with growth and necrotising enterocolitis in extremely preterm infants-A dual national cohort study. LID - 10.1038/s41390-026-04849-0 [doi] AB - BACKGROUND: In Sweden, the incidence of necrotising enterocolitis (NEC) in extremely preterm infants has increased from 6 to 10% over a decade. We examined whether changes in enteral nutrition during the first 2 weeks were associated with growth and development of NEC. METHODS: The EXPRESS (2004-2007) and EXPRESS 2 (2014-2016) cohorts included infants <27 gestational weeks. NEC diagnoses were validated. Nutritional data were retrieved from four of the six healthcare regions (n = 815). Growth and NEC incidence were compared between cohorts, and odds ratios (OR) were adjusted for early risk factors in a logistic regression model. RESULTS: In EXPRESS 2, during the first postnatal week, feeding advancement was more rapid (10 vs. 8 ml/kg/d, p < 0.001) and fortification more common (27% vs. 3.6%, p < 0.001). Growth improved from birth to 28 days (delta z-scores: weight, -2.18 vs. -1.49, p < 0.001; length, -2.22 vs. -1.96, p = 0.013) and to 36 weeks' postmenstrual age. Neither feeding advancement nor fortification was associated with increased NEC risk >7 d (n = 44; aOR 0.96, 95% CI 0.91-1.01, p = 0.15; aOR 1.33, 95% CI 0.57-2.79, p = 0.50). CONCLUSION: A more active early enteral nutrition policy in Sweden was associated with faster feeding advancement, earlier fortification, increased protein intake, and improved growth without increased NEC risk. IMPACT: Human breastmilk fortification increased, and macronutrient intakes improved among extremely preterm infants in Sweden during the years 2014-2016, compared to 2004-2007. Weight and length growth improved during the years 2014-2016. More active enteral nutrition during 2014-2016 was not associated with an increased incidence of necrotising enterocolitis. The study uses validated, population-based data from two national cohorts with high-resolution daily nutrition and growth records. Findings support earlier feeding advancement and fortification to improve growth without increasing necrotising enterocolitis risk in extremely preterm infants. CI - (c) 2026. The Author(s). FAU - Challis, Pontus AU - Challis P AD - Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden. pontus.challis@umu.se. FAU - Stoltz Sjostrom, Elisabeth AU - Stoltz Sjostrom E AD - Department of Food, Nutrition and Culinary Science, Umea University, Umea, Sweden. FAU - Elfvin, Anders AU - Elfvin A AD - Department of Paediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Department of Paediatrics, Region Vastra Gotaland, Sahlgrenska University Hospital, The Queen Silvia Children's Hospital, Gothenburg, Sweden. FAU - Naver, Lars AU - Naver L AD - Astrid Lindgren Children's Hospital, Karolinska University Hospital, Stockholm, Sweden. AD - Department of Clinical Science, Intervention and Technology (CLINTEC), Division of Pediatrics, Karolinska Institutet, Stockholm, Sweden. FAU - Abrahamsson, Thomas AU - Abrahamsson T AD - Department of Biomedical and Clinical Sciences and Department of Paediatrics, Linkoping University, Crown Princess Victoria Children's Hospital, University Hospital, Linkoping, SE-581 85, Sweden. FAU - Domellof, Magnus AU - Domellof M AD - Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden. LA - eng PT - Journal Article DEP - 20260407 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/04/08 00:30 MHDA- 2026/04/08 00:30 CRDT- 2026/04/07 23:25 PHST- 2025/11/07 00:00 [received] PHST- 2026/01/25 00:00 [accepted] PHST- 2026/01/21 00:00 [revised] PHST- 2026/04/08 00:30 [pubmed] PHST- 2026/04/08 00:30 [medline] PHST- 2026/04/07 23:25 [entrez] AID - 10.1038/s41390-026-04849-0 [pii] AID - 10.1038/s41390-026-04849-0 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Apr 7. doi: 10.1038/s41390-026-04849-0. PMID- 41946270 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260714 IS - 1476-5616 (Electronic) IS - 0033-3506 (Linking) VI - 255 DP - 2026 Jun TI - The impact of public health service on rural children's health: Quasi-experimental evidence from China. PG - 106263 LID - S0033-3506(26)00132-0 [pii] LID - 10.1016/j.puhe.2026.106263 [doi] AB - OBJECTIVES: This study evaluates the impact of a major maternal and child health service program on the health outcomes of children in rural China. STUDY DESIGN: Quasi-experimental study. METHODS: We utilize data from the China Family Panel Studies (CFPS) spanning 2012 to 2018, leveraging a regression discontinuity (RD) design with March 2006 as the cutoff to identify the program's causal effects. Our empirical strategy includes a series of robustness checks, such as RD validity tests, alternative bandwidths and functional forms, placebo cutoffs, exclusion of a confounding policy, and a combined RD-DID approach. RESULTS: The program yields significant improvements in rural children's health. We find a 5% reduction in hospitalization rates and a 53.7% increase in hospital delivery rates, accompanied by improvements in nutritional status, as reflected by a 0.082 increase in BMI Z-scores. Placebo test results show no significant effects, supporting our identification strategy and suggesting a narrowing of the urban-rural health gap. Additional analysis indicates that the program significantly reduces out-of-pocket medical expenditures for rural households, with particularly pronounced benefits for low-income families. CONCLUSIONS: The maternal and child health service program has proven to be an effective intervention for improving child health and reducing health disparities, particularly between urban and rural areas as well as within rural communities. These findings underscore the program's critical role in promoting health equity and accelerating progress toward universal health coverage. CI - Copyright (c) 2026 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved. FAU - Shen, Taotao AU - Shen T AD - Institute of Financial Risk Management, Shanxi University of Finance and Economics, No.140, Wucheng Road, Xiaodian District, Taiyuan, 030006, China. Electronic address: shyercz@163.com. FAU - Liu, Huan AU - Liu H AD - College of Economics and Management, Nanjing Agricultural University, No.1, Weigang Road, Xuanwu District, Nanjing, 210095, China. Electronic address: lhnenu0922@163.com. LA - eng PT - Journal Article DEP - 20260406 PL - Netherlands TA - Public Health JT - Public health JID - 0376507 SB - IM MH - Humans MH - China MH - *Child Health/statistics & numerical data MH - Female MH - Child MH - *Rural Population/statistics & numerical data MH - Child, Preschool MH - Male MH - Infant MH - Program Evaluation OTO - NOTNLM OT - Child health OT - Early childhood development OT - Health services OT - Maternal and child OT - Rural China COIS- Declaration of competing interest The authors declare that they have no competing interests. EDAT- 2026/04/08 00:30 MHDA- 2026/05/03 05:27 CRDT- 2026/04/07 18:08 PHST- 2025/11/14 00:00 [received] PHST- 2026/02/18 00:00 [revised] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/05/03 05:27 [medline] PHST- 2026/04/08 00:30 [pubmed] PHST- 2026/04/07 18:08 [entrez] AID - S0033-3506(26)00132-0 [pii] AID - 10.1016/j.puhe.2026.106263 [doi] PST - ppublish SO - Public Health. 2026 Jun;255:106263. doi: 10.1016/j.puhe.2026.106263. Epub 2026 Apr 6. PMID- 41946213 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260909 IS - 1873-5711 (Electronic) IS - 1050-6411 (Print) IS - 1050-6411 (Linking) VI - 88 DP - 2026 Jun TI - Kinematic effects of two therapeutic interventions for glenohumeral joint instability: A preliminary feasibility trial. PG - 103147 LID - S1050-6411(26)00043-X [pii] LID - 10.1016/j.jelekin.2026.103147 [doi] AB - PURPOSE: Multidirectional instability (MDI) of the glenohumeral joint involves excessive humeral translations with symptoms such as pain or apprehension. As MDI is typically managed through therapeutic exercise, this feasibility study examined the practicality of comparing targeted stabilization and general-strengthening interventions on glenohumeral kinematics and patient-reported outcomes. SCOPE: Twenty competitive swimmers with MDI were randomized to a targeted rehabilitation group (MDI-EX) or a general shoulder exercise group (GSE). Participants completed 16 exercise sessions over eight weeks. Glenohumeral kinematics were captured with dynamic biplane radiography. The change in humeral position, instantaneous helical axis dispersion, and contact path length during arm activity were examined. Western Ontario Shoulder Instability (WOSI) scores collected before, after, and eight weeks after intervention were evaluated. There were no significant kinematic differences between groups (p = 0.07-0.99; effect sizes: 0.02-0.41). WOSI scores improved significantly after the intervention and at eight weeks (p < 0.01). Consistent kinematic changes and moderate effect sizes support the feasibility of larger studies. CONCLUSION: This study demonstrates that measuring kinematic and patient-reported outcomes in MDI is feasible in a research setting, with early findings supporting further evaluation of targeted rehabilitation in larger cohorts. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Silverson, Oliver A AU - Silverson OA AD - Minnesota Rehabilitation Biomechanics Laboratory, Division of Physical Therapy and Rehabilitation Science, Department of Family Medicine and Community Health, Medical School, University of Minnesota, Minneapolis, MN, USA. Electronic address: silve677@umn.edu. FAU - Gruber, Chelsea L AU - Gruber CL AD - Department of Intercollegiate Athletics, University of Minnesota, Minneapolis, MN, USA. FAU - Staker, Justin L AU - Staker JL AD - Minnesota Rehabilitation Biomechanics Laboratory, Division of Physical Therapy and Rehabilitation Science, Department of Family Medicine and Community Health, Medical School, University of Minnesota, Minneapolis, MN, USA; Department of Intercollegiate Athletics, University of Minnesota, Minneapolis, MN, USA. LA - eng GR - UL1 TR002494/TR/NCATS NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial DEP - 20260327 PL - England TA - J Electromyogr Kinesiol JT - Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology JID - 9109125 SB - IM EIN - J Electromyogr Kinesiol. 2026 Oct;90:103183. doi: 10.1016/j.jelekin.2026.103183. PMID: 42365741 MH - Humans MH - *Joint Instability/rehabilitation/physiopathology MH - Female MH - Feasibility Studies MH - Male MH - *Shoulder Joint/physiopathology MH - Treatment Outcome MH - Biomechanical Phenomena MH - *Exercise Therapy/methods MH - Adolescent MH - Range of Motion, Articular PMC - PMC13552064 MID - NIHMS2163424 OTO - NOTNLM OT - Dynamic biplane radiography OT - Feasibility study OT - Glenohumeral kinematics OT - Multidirectional instability (MDI) OT - Rehabilitation interventions COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/08 00:30 MHDA- 2026/05/15 00:31 PMCR- 2026/09/08 CRDT- 2026/04/07 18:07 PHST- 2025/01/30 00:00 [received] PHST- 2026/03/05 00:00 [revised] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/05/15 00:31 [medline] PHST- 2026/04/08 00:30 [pubmed] PHST- 2026/04/07 18:07 [entrez] PHST- 2026/09/08 00:00 [pmc-release] AID - S1050-6411(26)00043-X [pii] AID - 10.1016/j.jelekin.2026.103147 [doi] PST - ppublish SO - J Electromyogr Kinesiol. 2026 Jun;88:103147. doi: 10.1016/j.jelekin.2026.103147. Epub 2026 Mar 27. PMID- 41946173 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260714 IS - 1873-622X (Electronic) IS - 0005-7967 (Linking) VI - 201 DP - 2026 Jun TI - The three circle model of compassion focused therapy: An experimental paradigm to assess dynamic psychophysiological changes of emotion regulation systems. PG - 105028 LID - S0005-7967(26)00080-X [pii] LID - 10.1016/j.brat.2026.105028 [doi] AB - Compassion Focused Therapy (CFT) is an integrated, evolutionary-informed biopsychosocial therapy model. Several systematic reviews and meta-analyses of CFT indicate that it is effective for a range of different clinical and non-clinical populations to improve overall mental health and wellbeing. Central to CFT is the tripartite model of emotion regulation, consisting of threat, drive, and soothing systems. The digital Three Circles Scale (d3CS), a novel measure of the tripartite model, has been validated with adults and teenagers, however, its link to physiological changes in controlled experimental conditions has not been tested. This study tests the theory-driven proposition of the d3CS in an experimental paradigm. This study recruited 88 adults aged 18-30 (M = 20.5, SD = 2.91) who completed baseline measurements of trait self-compassion, fears of compassion, and difficulties in emotion regulation. Participants then completed the experimental paradigm which included a rest, rumination, and recovery phase, as well as a compassionate imagery exercise. Across the phases, heart rate variability (HRV) was measured, and in each task the participants' d3CS ratings were assessed. Results indicated the circles moved in the predicted direction according to task, that HRV increased in response to recovery after rumination, and that the ratio of soothing dominance to threat and drive dominance shifted with changes in HRV. These data provide evidential support for the tripartite model as a key target in CFT which can be measured with the d3CS. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Moloney-Gibb, Dylan AU - Moloney-Gibb D AD - The Compassionate Mind Research Group, The School of Psychology, The University of Queensland, St Lucia, QLD, 4072, Australia. Electronic address: d.moloneygibb@uq.edu.au. FAU - Sherwell, Chase AU - Sherwell C AD - The Compassionate Mind Research Group, The School of Psychology, The University of Queensland, St Lucia, QLD, 4072, Australia. FAU - Lynn, Sasha AU - Lynn S AD - The Compassionate Mind Research Group, The School of Psychology, The University of Queensland, St Lucia, QLD, 4072, Australia; Has since moved to School of Education, Queensland University of Technology, GPO Box 2434, Brisbane, QLD, 4001, Australia. FAU - Kirby, James N AU - Kirby JN AD - The Compassionate Mind Research Group, The School of Psychology, The University of Queensland, St Lucia, QLD, 4072, Australia. LA - eng PT - Journal Article DEP - 20260402 PL - England TA - Behav Res Ther JT - Behaviour research and therapy JID - 0372477 SB - IM MH - Humans MH - *Emotional Regulation/physiology MH - *Empathy/physiology MH - Adult MH - Female MH - Young Adult MH - Adolescent MH - Heart Rate/physiology MH - Male MH - Models, Psychological OTO - NOTNLM OT - CFT OT - Compassion focused therapy OT - Heart rate variability OT - Three circles: tripartite model of affect regulation COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/08 00:30 MHDA- 2026/05/08 00:32 CRDT- 2026/04/07 18:06 PHST- 2025/12/29 00:00 [received] PHST- 2026/03/14 00:00 [revised] PHST- 2026/04/01 00:00 [accepted] PHST- 2026/05/08 00:32 [medline] PHST- 2026/04/08 00:30 [pubmed] PHST- 2026/04/07 18:06 [entrez] AID - S0005-7967(26)00080-X [pii] AID - 10.1016/j.brat.2026.105028 [doi] PST - ppublish SO - Behav Res Ther. 2026 Jun;201:105028. doi: 10.1016/j.brat.2026.105028. Epub 2026 Apr 2. PMID- 41945642 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 28 DP - 2026 Apr 7 TI - A Gamified Mobile Health Intervention to Promote Physical Activity, Executive Function, and Mental Health in College Students: Randomized Controlled Trial. PG - e82769 LID - 10.2196/82769 [doi] LID - e82769 AB - BACKGROUND: College students commonly experience suboptimal health conditions, including insufficient physical activity (PA), excessive body weight, and declining physical fitness. Traditional interventions face low adherence, while gamified mobile health (mHealth) programs may improve engagement and outcomes. OBJECTIVE: This study aimed to evaluate the feasibility and effectiveness of a novel gamified, incentive-based mHealth intervention on primary outcomes (PA and adherence) and secondary outcomes (physical fitness, body composition, executive function [EF], and mental health). METHODS: A 2-arm parallel-group randomized controlled trial (RCT) was conducted in 2025 at Yantai University with 160 college students (18-25 years; BMI 18.5-30.0) who were randomized 1:1 (computer-generated, sex-stratified blocks of 4; concealed allocation) to the intervention group (IG) or control group (CG; n=80 each); major exclusions were contraindications to exercise, severe physical/mental illness, recent PA interventions, or psychotropic medication use. Both used the same fitness watch-app system and identical PA targets (>/=150 min moderate-to-vigorous physical activity [MVPA] per week or >/=900 metabolic equivalent-minutes [MET-min] per week); IG additionally received team-based gamification (competition, points/leaderboards, feedback, and rewards), while CG received monitoring only. PA and adherence were monitored throughout the 8-week intervention; other outcomes were assessed at baseline and 8 weeks (fitness, body composition, EF, and mental health). Open-label with blinded outcome assessors/analysts; intention-to-treat (ITT) with multiple imputation. RESULTS: At 8 weeks, data were available for 154 participants (IG 78; CG 76); all 160 were analyzed per ITT. Compared to the CG, the IG demonstrated significantly higher mean levels in all primary PA outcomes over 8 weeks (daily steps: mean 10,356, SD 1245 versus 8242, SD 1087; Delta=2114; d=1.81, 95% CI 1.44-2.18; P<.001; daily MVPA: mean 71, SD 15 versus 43, SD 12 min; Delta=28 min; d=2.06, 95% CI 1.68-2.45; P<.001; and weekly MET-min: mean 1650, SD 310 versus 1340, SD 285; Delta=310; d=1.04, 95% CI 0.71-1.37; P<.001). Adherence was also higher in the IG (both P<.001). Key secondary outcomes, including skeletal muscle mass (Delta +0.54 kg), body fat percentage (Delta -0.46 percentage points), 800/1000 m run time (Delta -6.5 s), and depressive symptoms (Delta -2.0 points), significantly favored the IG (all P<.001). No serious adverse events occurred. CONCLUSIONS: This RCT demonstrated that integrating gamification into an mHealth platform significantly enhanced PA, intervention adherence, and selected health outcomes among college students. The key innovation lies in the trial design, which held the technology platform and activity goals constant across groups, thereby allowing a clearer estimate of the incremental contribution of gamification. Unlike many existing studies, this approach reduces confounding from co-occurring intervention components in between-group comparisons. It therefore provides more comparable and methodologically robust evidence on the specific efficacy of gamification in mHealth interventions. For real-world implementation, this model leverages the existing smartphone and wearable ecosystem, offering a low-cost, scalable strategy for university health-promotion programs. CI - (c) Ming Yang, Yingjun Guo, Zhen Li, Lei Jiang, Yanan Gao, Sen Yang, Zhixiong Zhou. Originally published in the Journal of Medical Internet Research (https://www.jmir.org). FAU - Yang, Ming AU - Yang M AUID- ORCID: 0009-0000-4849-1732 AD - Institute of Artificial Intelligence in Sports, Capital University of Physical Education and Sports, No.11, North Third Ring West Road, Haidian District, Beijing, 100191, China, 86 13552505679. AD - School of Physical Education, Yantai University, Yantai, Shandong, China. FAU - Guo, Yingjun AU - Guo Y AUID- ORCID: 0009-0006-4708-3140 AD - Beijing Sport University Press, Beijing Sport University, Beijing, Beijing, China. FAU - Li, Zhen AU - Li Z AUID- ORCID: 0000-0002-1432-7472 AD - School of Physical Education and Sport Science, Fujian Normal University, Fuzhou, Fujian, China. FAU - Jiang, Lei AU - Jiang L AUID- ORCID: 0009-0001-8591-6805 AD - Institute of Artificial Intelligence in Sports, Capital University of Physical Education and Sports, No.11, North Third Ring West Road, Haidian District, Beijing, 100191, China, 86 13552505679. FAU - Gao, Yanan AU - Gao Y AUID- ORCID: 0000-0002-3641-5449 AD - School of Physical Education and Sport Science, Fujian Normal University, Fuzhou, Fujian, China. FAU - Yang, Sen AU - Yang S AUID- ORCID: 0009-0009-3907-6356 AD - Institute of Artificial Intelligence in Sports, Capital University of Physical Education and Sports, No.11, North Third Ring West Road, Haidian District, Beijing, 100191, China, 86 13552505679. FAU - Zhou, Zhixiong AU - Zhou Z AUID- ORCID: 0000-0003-3369-1429 AD - Institute of Artificial Intelligence in Sports, Capital University of Physical Education and Sports, No.11, North Third Ring West Road, Haidian District, Beijing, 100191, China, 86 13552505679. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260407 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 SB - IM MH - Humans MH - *Executive Function MH - Male MH - Female MH - Adolescent MH - Young Adult MH - *Mental Health MH - *Students/psychology MH - Universities MH - *Telemedicine MH - Adult MH - *Exercise MH - Physical Fitness MH - *Health Promotion/methods MH - *Video Games MH - Digital Health MH - *Gamification PMC - PMC13055952 OTO - NOTNLM OT - adherence OT - cognitive function OT - eHealth OT - gamification OT - mHealth OT - physical fitness OT - psychological well-being COIS- Conflicts of Interest: None declared. EDAT- 2026/04/07 18:31 MHDA- 2026/04/07 18:32 PMCR- 2026/04/07 CRDT- 2026/04/07 13:53 PHST- 2025/08/21 00:00 [received] PHST- 2026/02/04 00:00 [revised] PHST- 2026/03/06 00:00 [accepted] PHST- 2026/04/07 18:32 [medline] PHST- 2026/04/07 18:31 [pubmed] PHST- 2026/04/07 13:53 [entrez] PHST- 2026/04/07 00:00 [pmc-release] AID - v28i1e82769 [pii] AID - 82769 [pii] AID - 10.2196/82769 [doi] PST - epublish SO - J Med Internet Res. 2026 Apr 7;28:e82769. doi: 10.2196/82769. PMID- 41945012 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260714 IS - 1590-3729 (Electronic) IS - 0939-4753 (Linking) VI - 36 IP - 7 DP - 2026 Jul TI - Cardiorespiratory fitness from childhood to midlife and Life's Essential 8 cardiovascular health score. PG - 104640 LID - S0939-4753(26)00102-X [pii] LID - 10.1016/j.numecd.2026.104640 [doi] AB - BACKGROUND AND AIMS: Cardiorespiratory fitness (CRF) is a modifiable cardiovascular risk factor for children and adults. However, little is known how variations in CRF across the life course impact long-term cardiovascular health. Therefore, we examined how CRF from childhood to mid-adulthood associates with the American Heart Association's (AHA) Life's Essential 8 (LE8), a measure of overall cardiovascular health. METHODS AND RESULTS: As part of the longitudinal Childhood Determinants of Adult Health Study, 240 participants had their CRF measured as physical work capacity at 170 beats per minute (PWC(170)) in childhood (1985: 9, 12, 15 years), young adulthood (2004-06: 26-36 years), and mid-adulthood (2014-19: 36-49 years). In mid-adulthood, diet, physical activity, smoking, sleep, body mass index, blood lipids, blood glucose and blood pressure was assessed, with LE8 scores created following AHA recommendations. Associations were examined using linear regression and the Bayesian relevant life course model. The relationship between CRF across the life course and adult LE8 was best characterised by a lifetime growth model, where higher childhood CRF (beta = 3.48, 95%CI = 1.36-5.60), and increased CRF between childhood and young adulthood (beta = 3.64, 95%CI = 2.12-5.17) and between young and mid-adulthood (beta = 4.15, 95%CI = 2.23-6.06) were positively associated with LE8 in midlife. When the relative importance of CRF within this relationship was quantified, CRF was important at each examined life stage, with a sensitive period in midlife. CONCLUSION: These findings support a life course approach to the prevention of adverse cardiovascular health, highlighting the cardiovascular benefits of higher CRF in both childhood and adulthood, and increasing CRF over time. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Fraser, Brooklyn J AU - Fraser BJ AD - Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia; Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Adelaide, Australia. Electronic address: brooklyn.fraser@utas.edu.au. FAU - Blizzard, Leigh AU - Blizzard L AD - Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia. FAU - Tomkinson, Grant R AU - Tomkinson GR AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Adelaide, Australia. FAU - Dwyer, Terence AU - Dwyer T AD - Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia; The Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK; Murdoch Children's Research Institute, Melbourne, Australia; Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Australia. FAU - Venn, Alison J AU - Venn AJ AD - Menzies Institute for Medical Research, University of Tasmania, Hobart, Australia. FAU - Magnussen, Costan G AU - Magnussen CG AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), University of South Australia, Adelaide, Australia; Baker Heart and Diabetes Institute, Melbourne, Australia; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland; Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. LA - eng PT - Journal Article DEP - 20260226 PL - Netherlands TA - Nutr Metab Cardiovasc Dis JT - Nutrition, metabolism, and cardiovascular diseases : NMCD JID - 9111474 SB - IM MH - Humans MH - *Cardiorespiratory Fitness MH - Child MH - Male MH - Female MH - Middle Aged MH - Adult MH - *Cardiovascular Diseases/diagnosis/epidemiology/prevention & control/physiopathology MH - Age Factors MH - Risk Assessment MH - Heart Disease Risk Factors MH - Adolescent MH - Health Status MH - Young Adult MH - Longitudinal Studies MH - Time Factors MH - Predictive Value of Tests MH - Risk Factors OTO - NOTNLM OT - American heart association OT - Cardiorespiratory fitness OT - Cardiovascular diseases OT - Cohort studies OT - Epidemiology COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2026/04/07 12:33 MHDA- 2026/05/15 00:31 CRDT- 2026/04/07 11:08 PHST- 2025/08/29 00:00 [received] PHST- 2026/02/04 00:00 [revised] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/05/15 00:31 [medline] PHST- 2026/04/07 12:33 [pubmed] PHST- 2026/04/07 11:08 [entrez] AID - S0939-4753(26)00102-X [pii] AID - 10.1016/j.numecd.2026.104640 [doi] PST - ppublish SO - Nutr Metab Cardiovasc Dis. 2026 Jul;36(7):104640. doi: 10.1016/j.numecd.2026.104640. Epub 2026 Feb 26. PMID- 41944765 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260715 IS - 2214-0190 (Electronic) IS - 0895-3988 (Linking) VI - 39 IP - 3 DP - 2026 Mar 20 TI - Levels and Disparities of 24-hour Movement Behaviors of Chinese Children Aged 3-5 Years: A Nationally Representative Cross-sectional Study (2019-2021). PG - 285-296 LID - 10.3967/bes2025.151 [doi] AB - OBJECTIVE: This study aimed to describe 24-hour movement behaviors, including physical activity, sedentary behavior, and sleep period, among Chinese preschoolers using nationally representative data, and examine disparities by age, gender, and residence. METHODS: A cross-sectional analysis was conducted using data from the China National Nutrition and Health Systematic Survey for Children (2019-2021), including 10,935 children aged 3-5 years. Daily total time of physical activity (TPA), total time of sedentary behaviors (TSB), and total sleep period (TSP) was collected via validated structured questionnaires. Physical inactivity was defined as < 180 minutes of TPA per day. RESULTS: Median TPA was 121.4 ( IQR: 71.4-209.6) minutes/day, and TSB was 231.4 ( IQR: 175.0-304.3) minutes/day, with 11.46 +/- 1.00 hours/day average TSP. Overall, 68.8% were physically inactive, with higher prevalence in rural (73.3%) versus urban areas (64.8%, P < 0.001). TPA and TSB increased with age, while TSP decreased (all P < 0.001). No significant gender differences were observed. CONCLUSION: Most Chinese preschoolers exhibit insufficient physical activity and excessive sedentary behaviors, with notable urban-rural disparities and an escalating trend of ageing. Continuous monitoring and targeted interventions, especially in rural areas, are urgently needed. CI - Copyright (c) 2026 The Editorial Board of Biomedical and Environmental Sciences. Published by China CDC. All rights reserved. FAU - Duan, Yi Fan AU - Duan YF AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Key Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China. Key Laboratory of Human Breast Milk Science, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Zhang, Ji AU - Zhang J AD - School of Population Medicine and Public Health, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China. FAU - Guo, Lin Xiao AU - Guo LX AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Key Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China. Key Laboratory of Human Breast Milk Science, Chinese Center for Disease Control and Prevention, Beijing 100050, China;Guangdong Polytechnic of Science and Trade, Guangzhou 510430, Guangdong, China. FAU - Pang, Xue Hong AU - Pang XH AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Key Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China. Key Laboratory of Human Breast Milk Science, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Zhang, Qian AU - Zhang Q AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Key Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China. Key Laboratory of Human Breast Milk Science, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Wang, Yu Ying AU - Wang YY AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Key Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China. Key Laboratory of Human Breast Milk Science, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Xu, Tao AU - Xu T AD - National Center for Women and Children's Health, National Health Commission of the People's Republic of China, Beijing 100081, China. FAU - Chen, Bo Wen AU - Chen BW AD - Capital Institute of Pediatrics, Beijing 100020, China. FAU - Yang, Zhen Yu AU - Yang ZY AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Key Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China. Key Laboratory of Human Breast Milk Science, Chinese Center for Disease Control and Prevention, Beijing 100050, China. FAU - Zhao, Wen Hua AU - Zhao WH AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention. Key Laboratory of Public Nutrition and Health, National Health Commission of the People's Republic of China. Key Laboratory of Human Breast Milk Science, Chinese Center for Disease Control and Prevention, Beijing 100050, China. LA - eng PT - Journal Article PL - China TA - Biomed Environ Sci JT - Biomedical and environmental sciences : BES JID - 8909524 RN - Chinese people SB - IM MH - Humans MH - Cross-Sectional Studies MH - China MH - Female MH - Male MH - *Sedentary Behavior MH - Child, Preschool MH - *Sleep MH - *Exercise MH - Sleep Duration MH - East Asian People OTO - NOTNLM OT - Physical activity OT - Physical inactivity OT - Preschool children OT - Sedentary behavior OT - Sleep duration OT - Urban-rural disparity EDAT- 2026/04/07 12:32 MHDA- 2026/04/07 12:33 CRDT- 2026/04/07 10:13 PHST- 2025/04/30 00:00 [received] PHST- 2025/10/13 00:00 [accepted] PHST- 2026/04/07 12:33 [medline] PHST- 2026/04/07 12:32 [pubmed] PHST- 2026/04/07 10:13 [entrez] AID - 10.3967/bes2025.151 [doi] PST - ppublish SO - Biomed Environ Sci. 2026 Mar 20;39(3):285-296. doi: 10.3967/bes2025.151. PMID- 41944689 OWN - NLM STAT- MEDLINE DCOM- 20260723 LR - 20260723 IS - 1533-4287 (Electronic) IS - 1064-8011 (Linking) VI - 40 IP - 8 DP - 2026 Aug 1 TI - Accelerometry Insights Into Gym-Based Plyometric Exercises; Evaluating Metrics, Reliability, and Sensor Placement. PG - e784-e791 LID - 10.1519/JSC.0000000000005424 [doi] AB - McGillivray, I, Murphy, A, Reid, M, Perri, T, and Duffield, R. Accelerometry insights into gym-based plyometric exercises; evaluating metrics, reliability, and sensor placement. J Strength Cond Res 40(8): e784-e791, 2026-Quantification of training load is important for athletic performance, yet traditional field-based accelerometry often fails to capture gym-based training demands, particularly in the vertical plane. This study investigates the use of triaxial accelerometry for assessing training load in gym-based plyometric exercises, examining the influence of sensor placement and the reliability of accelerometry-derived metrics. Ten elite youth tennis players (16.0 +/- 1.6 years) completed a standardized plyometric session on 2 occasions, consisting of 4 sets of 7 exercises, performed in a superset sequence. Inertial measurement units (IMUs) were worn at 4 anatomical locations (thoracic spine, lumbar spine, left ankle, right ankle), collecting 4 key metrics: peak upward acceleration (PUpAcc), 1D upward PlayerLoad (1DPL-up), 2D PlayerLoad (2DPL), and 3D PlayerLoad (3DPL). Results showed skater hops consistently produced the lowest acceleration magnitudes, whereas altitude landings recorded the highest. Ankle-mounted sensors recorded significantly higher acceleration values than thoracic and lumbar placements ( p < 0.05), confirming the attenuation of signals up the body. PlayerLoad metrics demonstrated strong agreement across sensor locations ( r = 0.50-0.96) in 119/126 comparisons, whereas PUpAcc showed lower associations ( r = 0.01-0.57). Moderate to good reliability values (intraclass correlation coefficient = 0.50-0.84) existed across all metrics, with greater consistency in PlayerLoad metrics compared with PUpAcc. Overall, sensor placement influences accelerometry-derived measures of plyometric activities, with PlayerLoad metrics demonstrating intersensor agreement and reliability across placements. Although thoracic-mounted IMUs capture whole-body motion, they may underestimate lower-limb loading. These preliminary findings support using PlayerLoad metrics for monitoring gym-based plyometrics while highlighting the need for further research into PUpAcc as a measure of impact-related acceleration. CI - Copyright (c) 2026 National Strength and Conditioning Association. FAU - McGillivray, Isabel AU - McGillivray I AD - School of Sport, Exercise & Rehabilitation, Faculty of Health, University of Technology Sydney, New South Wales, Australia; and. AD - Tennis Australia, Melbourne, Victoria, Australia. FAU - Murphy, Alistair AU - Murphy A AD - Tennis Australia, Melbourne, Victoria, Australia. FAU - Reid, Machar AU - Reid M AD - Tennis Australia, Melbourne, Victoria, Australia. FAU - Perri, Thomas AU - Perri T AD - Tennis Australia, Melbourne, Victoria, Australia. FAU - Duffield, Rob AU - Duffield R AD - School of Sport, Exercise & Rehabilitation, Faculty of Health, University of Technology Sydney, New South Wales, Australia; and. LA - eng PT - Journal Article DEP - 20260408 PL - United States TA - J Strength Cond Res JT - Journal of strength and conditioning research JID - 9415084 SB - IM MH - Humans MH - *Accelerometry/methods/instrumentation MH - Reproducibility of Results MH - *Plyometric Exercise/methods MH - Adolescent MH - Tennis/physiology MH - Acceleration MH - Ankle/physiology MH - Male MH - Lumbar Vertebrae/physiology OTO - NOTNLM OT - plyometric training OT - tennis OT - training load monitoring OT - wearable technology EDAT- 2026/04/07 12:32 MHDA- 2026/07/23 12:37 CRDT- 2026/04/07 09:43 PHST- 2026/07/23 12:37 [medline] PHST- 2026/04/07 12:32 [pubmed] PHST- 2026/04/07 09:43 [entrez] AID - 00124278-990000000-00947 [pii] AID - 10.1519/JSC.0000000000005424 [doi] PST - ppublish SO - J Strength Cond Res. 2026 Aug 1;40(8):e784-e791. doi: 10.1519/JSC.0000000000005424. Epub 2026 Apr 8. PMID- 41944488 OWN - NLM STAT- Publisher LR - 20260407 IS - 1466-447X (Electronic) IS - 0264-0414 (Linking) DP - 2026 Apr 7 TI - Effects of a ChatGPT-generated eccentric training programme on speed, change of direction, agility, and jumping performance in U14 tennis players: A non-randomised controlled study. PG - 1-10 LID - 10.1080/02640414.2026.2653295 [doi] AB - This non-randomised controlled-trial aimed to examine the effects of a ChatGPT-generated eccentric training (ET) programme, which was subsequently validated by human experts before implementation, on physical fitness in U14 tennis players. Twenty-four youth players were recruited and assigned to either the ET-group (n = 13; 7 females; age = 13.19 +/- 0.98 years) or the active control-group (CG; n = 11; 6 females; age = 13.13 +/- 0.52 years). The AI-designed ET programme was implemented over 8 weeks, during which the CG continued their regular tennis training without additional ET. Participants were tested on linear-sprint-speed (5- and 10-m sprints), change-of-direction (CoD) speed (505-CoD), vertical-jump (countermovement-jump, CMJ), horizontal-jump (standing-long-jump, SLJ), and drop-jump (20-cm drop-jump, DJ-20) performances. Significant group-by-time interactions were found for 5-m sprint, 505-CoD, and Y-Agility performances (p < 0.05), indicating greater improvements in the ET-group (d = 0.6 to 2.15) compared to CG (d = 0.15 to 0.6). For 10-m sprint and jump tests, no significant group-by-time interactions were reported. Individual response analysis revealed that a higher proportion of ET-group participants (73-100%) improved their performance beyond the smallest-worthwhile-change (SWC(0.2)) threshold across all tests, compared to the CG (18-63%). The present findings support the effectiveness and practicality of the ChatGPT-designed ET programmes for improving physical fitness in U14 tennis players. FAU - Negra, Yassine AU - Negra Y AD - Research Laboratory (LR23JS01) <>, Manouba, Tunisia. AD - Higher Institute of Sport and Physical Education of Ksar Said, University of "La Manouba", Tunisia. FAU - Sammoud, Senda AU - Sammoud S AD - Research Laboratory (LR23JS01) <>, Manouba, Tunisia. AD - Universite de Jendouba, Institut Superieur de Sport et de l'Education Physique du Kef, Le Kef, Tunisie. FAU - Bouguezzi, Raja AU - Bouguezzi R AD - Research Laboratory (LR23JS01) <>, Manouba, Tunisia. FAU - Markov, Adrian AU - Markov A AD - UR 7480 Vertex, Universite de Caen, France. FAU - Capranica, Laura AU - Capranica L AD - Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy. FAU - Muller, Patrick AU - Muller P AD - Division of Cardiology and Angiology, Otto-von-Guericke University Magdeburg, University Hospital Magdeburg, Magdeburg, Germany. FAU - Chaabene, Helmi AU - Chaabene H AUID- ORCID: 0000-0001-7812-7931 AD - Universite de Jendouba, Institut Superieur de Sport et de l'Education Physique du Kef, Le Kef, Tunisie. AD - Division of Cardiology and Angiology, Otto-von-Guericke University Magdeburg, University Hospital Magdeburg, Magdeburg, Germany. LA - eng PT - Journal Article DEP - 20260407 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 SB - IM OTO - NOTNLM OT - Adolescents OT - artificial intelligence OT - physical performance OT - resistance training EDAT- 2026/04/07 12:33 MHDA- 2026/04/07 12:33 CRDT- 2026/04/07 08:03 PHST- 2026/04/07 12:33 [medline] PHST- 2026/04/07 12:33 [pubmed] PHST- 2026/04/07 08:03 [entrez] AID - 10.1080/02640414.2026.2653295 [doi] PST - aheadofprint SO - J Sports Sci. 2026 Apr 7:1-10. doi: 10.1080/02640414.2026.2653295. PMID- 41943951 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260825 IS - 1541-3144 (Electronic) IS - 0194-2638 (Linking) VI - 46 IP - 5 DP - 2026 TI - Feeding Self-Help Skills and Adaptive Behavior Are Related to Feeding Challenge Severity in Autistic Children. PG - 963-979 LID - 10.1080/01942638.2026.2652045 [doi] AB - AIMS: This project aimed to (1) Describe feeding self-help skills in autistic children with feeding challenges and (2) Identify the relationships among feeding self-help skills, feeding challenge severity, family mealtime factors, and adaptive behavior. METHODS: This study used data from a cross-sectional national survey of 358 caregivers of autistic children (ages 2-12 years) with feeding challenges, recruited through a national research registry. Data were captured using validated caregiver-report measures. Descriptive statistics were completed to characterize feeding self-help skills and additional variables within the sample. Pearson's R correlations were run to investigate relationships among variables. RESULTS: Feeding self-help skills, feeding challenge severity, and adaptive behavior scores were widely heterogeneous. Overall, children in the study required higher levels of support from caregivers to participate in feeding and had lower adaptive behavior than expected for their age. Significant Pearson r correlations ranging from 0.11 to 0.60 were observed between feeding self-help skills, feeding challenge severity, family mealtime factors, and adaptive behavior. CONCLUSIONS: Feeding self-help skills and adaptive behavior are essential to evaluate in autistic children with feeding challenges. Future research should explore component skills, (e.g. use of utensils) in addition to behavior and sensory components of feeding to inform child-centered evaluation and intervention. FAU - St John, Brittany M AU - St John BM AD - Waisman Center, University of Wisconsin, Madison, WI, USA. AD - Department of Rehabilitation Medicine, Division of Occupational Therapy, University of Washington, Seattle, WA, USA. FAU - Laufenberg, Hannah AU - Laufenberg H AD - Department of Kinesiology, Occupational Therapy Program, University of Wisconsin at Madison, Madison, WI, USA. FAU - Sommers, Mary AU - Sommers M AD - Department of Kinesiology, Occupational Therapy Program, University of Wisconsin at Madison, Madison, WI, USA. FAU - Sylvester, Gina AU - Sylvester G AD - Department of Kinesiology, Occupational Therapy Program, University of Wisconsin at Madison, Madison, WI, USA. FAU - Ausderau, Karla K AU - Ausderau KK AD - Waisman Center, University of Wisconsin, Madison, WI, USA. AD - Department of Kinesiology, Occupational Therapy Program, University of Wisconsin at Madison, Madison, WI, USA. LA - eng PT - Journal Article DEP - 20260407 PL - England TA - Phys Occup Ther Pediatr JT - Physical & occupational therapy in pediatrics JID - 8109120 SB - IM MH - Humans MH - Child, Preschool MH - Child MH - Male MH - *Adaptation, Psychological MH - Cross-Sectional Studies MH - Female MH - *Autistic Disorder/psychology/physiopathology MH - *Feeding Behavior/psychology MH - Meals MH - Severity of Illness Index MH - Caregivers MH - *Self Care OTO - NOTNLM OT - Adaptive behavior OT - autism OT - family mealtime OT - feeding challenges OT - feeding self-help skills EDAT- 2026/04/07 06:31 MHDA- 2026/08/25 11:38 CRDT- 2026/04/07 04:33 PHST- 2026/08/25 11:38 [medline] PHST- 2026/04/07 06:31 [pubmed] PHST- 2026/04/07 04:33 [entrez] AID - 10.1080/01942638.2026.2652045 [doi] PST - ppublish SO - Phys Occup Ther Pediatr. 2026;46(5):963-979. doi: 10.1080/01942638.2026.2652045. Epub 2026 Apr 7. PMID- 41942933 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Apr 7 TI - Exploring the association between asthma-related knowledge among caregivers and asthma control in children. LID - 10.1186/s12887-026-06789-4 [doi] LID - 453 AB - BACKGROUND: Asthma is a common chronic disease among children. Despite the availability of effective asthma medication, a substantial proportion of children continue to experience poor asthma control. Caregivers play a critical role in asthma management in children. We aimed to examine caregivers' asthma-related knowledge and its relationship with asthma control in children and identify other factors influencing asthma control. METHODS: This cross-sectional study was conducted among children aged 2-15 years with asthma who received inhaled corticosteroids (ICS) between 2023 and 2024. Six months after ICS treatment, caregivers completed a validated 16-item questionnaire assessing asthma-related knowledge (score range: 16-64) and sociodemographic data. Asthma control levels were evaluated based on the Global Initiative for Asthma criteria. Poor control was defined as partial or uncontrolled. A multiple logistic regression analysis was performed to identify factors associated with poorly controlled asthma. RESULTS: The caregivers of 151 children participated in this study. The most common caregiver misconceptions included exercise-induced symptoms (31.8%), ICS safety (26.5%), and avoidance of exercise despite well-controlled asthma (14.6%). Poor asthma control was observed in 31 (20.5%) children. No significant difference in knowledge scores was found between the poorly and well-controlled groups (mean [standard deviation], 55.4 [4.0] vs. 54.1 [4.8]). Poor control was more prevalent in children aged /=2 VCTE studies. Disease regression and progression were defined using categorical and continuous changes in alanine aminotransferase (ALT) and gamma glutamyl transferase (GGT) previously linked to histologic improvement or worsening. Spaghetti plots illustrated trends over time, while longitudinal linear mixed-effects models and proportional odds mixed models assessed associations between CAP, LSM, and liver enzyme outcomes. RESULTS: The cohort included 149 children (72% male, 43% Hispanic) with a mean age of 14 +/- 4 years and a mean follow-up of 1.4 years. CAP and LSM showed marked intraindividual variability. Independent predictors of CAP change included age, body mass index (BMI) percentile, and glycated hemoglobin (HbA1c); predictors of LSM change included ALT, BMI, and HbA1c. Changes in CAP and LSM did not predict categorical outcomes of ALT and GGT reduction, however were significantly positively associated with continuous ALT and GGT outcomes, independent of BMI percentile. CONCLUSIONS: Longitudinal VCTE in pediatric MASLD has the potential to identify disease progression. The intraindividual variability of CAP and LSM may limit the ability to detect short-term regression or progression, highlighting the need for more precise noninvasive biomarkers for pediatric MASLD. CI - (c) 2026 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Diop-West, Naima AU - Diop-West N AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. FAU - Denson, Nicholas AU - Denson N AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. FAU - Arce-Clachar, Ana Catalina AU - Arce-Clachar AC AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. AD - University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. FAU - Bonn, Julie AU - Bonn J AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. AD - University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. FAU - Bramlage, Kristin AU - Bramlage K AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. FAU - Leesman, Lisa AU - Leesman L AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. FAU - Sahay, Rashmi D AU - Sahay RD AD - Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. FAU - Gecili, Emrah AU - Gecili E AD - University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. AD - Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. FAU - Trout, Andrew T AU - Trout AT AD - University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. AD - Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. FAU - Xanthakos, Stavra AU - Xanthakos S AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. AD - University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. FAU - Mouzaki, Marialena AU - Mouzaki M AUID- ORCID: 0000-0002-9809-6199 AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. AD - University of Cincinnati College of Medicine, Cincinnati, Ohio, USA. LA - eng GR - P30 DK078392/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20260406 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 RN - EC 2.3.2.2 (gamma-Glutamyltransferase) RN - EC 2.6.1.2 (Alanine Transaminase) SB - IM MH - Humans MH - *Elasticity Imaging Techniques/methods MH - Male MH - Longitudinal Studies MH - Female MH - Retrospective Studies MH - Child MH - Adolescent MH - Disease Progression MH - Vibration MH - *Liver/diagnostic imaging/pathology MH - *Fatty Liver/diagnostic imaging MH - gamma-Glutamyltransferase/blood MH - Alanine Transaminase/blood PMC - PMC13344883 MID - NIHMS2182512 OTO - NOTNLM OT - FibroScan OT - children OT - fatty liver OT - outcome COIS- Conflicts of interest and sources of funding: No conflicts. This work was supported by NIH grant P30 DK078392 (Clinical Component) of the Digestive Diseases Research Core Center in Cincinnati EDAT- 2026/04/06 06:30 MHDA- 2026/06/10 06:53 PMCR- 2026/07/08 CRDT- 2026/04/06 03:32 PHST- 2026/01/22 00:00 [revised] PHST- 2025/10/28 00:00 [received] PHST- 2026/02/18 00:00 [accepted] PHST- 2026/06/10 06:53 [medline] PHST- 2026/04/06 06:30 [pubmed] PHST- 2026/04/06 03:32 [entrez] PHST- 2026/07/08 00:00 [pmc-release] AID - 10.1002/jpn3.70423 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Jun;82(6):1366-1372. doi: 10.1002/jpn3.70423. Epub 2026 Apr 6. PMID- 41937219 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260520 LR - 20260813 IS - 2055-5784 (Print) IS - 2055-5784 (Electronic) IS - 2055-5784 (Linking) VI - 12 IP - 1 DP - 2026 Apr 6 TI - A machine learning approach to using ultrasound for body composition and nutritional status assessment in newborns: a pilot study protocol. LID - 10.1186/s40814-026-01814-w [doi] LID - 74 AB - BACKGROUND: Accurate assessment of infant body composition, specifically fat and fat-free mass, is crucial for evaluating growth and nutritional status. Existing methods, such as air displacement plethysmography and dual-energy X-ray absorptiometry, are expensive, require specialized facilities, and demand trained personnel. Ultrasound offers a promising alternative as a portable, low-cost tool capable of distinguishing adipose tissue from skeletal muscle. However, its feasibility for widespread use in diverse clinical settings remains uncertain. This pilot study aims to assess the feasibility, acceptability, and reliability of an ultrasound scanning protocol for measuring body composition in infants while establishing a foundation for artificial intelligence (AI)-enabled analysis to enable whole-body composition estimation from ultrasound images. METHODS: We will recruit 50 infants (20 preterm and 30 full-term infants) from two sites: Brigham and Women's Hospital (Boston, MA, USA) and Jimma Medical Center (Jimma, Ethiopia). Feasibility will be assessed through metrics such as recruitment rates, scan completion, and session duration. Acceptability will be measured using clinician feedback, and reliability will be evaluated using intra-class correlation coefficients (ICCs) for ultrasound image acquisition. A comprehensive database of ultrasound images and corresponding body composition metrics will be developed, forming the foundation for training AI models. Preliminary machine learning (ML) models, including convolutional neural networks (CNN), will be developed to predict body composition. The accuracy of these models will be evaluated using metrics such as root mean squared error (RMSE), mean absolute percent error (MAPE), mean absolute error (MAE), and mean squared error (MSE). DISCUSSION: This study will determine the feasibility of integrating ultrasound-based body composition assessment into neonatal clinical workflows as a potential future application. We will evaluate protocol adherence, scan reliability, and clinician and family acceptability to guide further protocol optimization. Findings will inform the design of a larger-scale study and contribute to refining AI models for clinical use. Ultimately, this approach aims to improve the accessibility, accuracy, and efficiency of body composition assessments, particularly in low-resource settings, where it could enable frontline healthcare workers to perform these assessments without specialized training, improving care for vulnerable infants. CI - (c) 2026. The Author(s). FAU - Ranger, Bryan J AU - Ranger BJ AUID- ORCID: 0000-0002-4774-3587 AD - Department of Engineering, Boston College, Chestnut Hill, MA, 02467, USA. bryan.ranger@bc.edu. AD - William F. Connell School of Nursing, Boston College, Chestnut Hill, MA, USA. bryan.ranger@bc.edu. FAU - Albert, Marisa AU - Albert M AD - William F. Connell School of Nursing, Boston College, Chestnut Hill, MA, USA. FAU - Kim, Ji In AU - Kim JI AD - William F. Connell School of Nursing, Boston College, Chestnut Hill, MA, USA. FAU - Cho, Hayoung AU - Cho H AD - Department of Engineering, Boston College, Chestnut Hill, MA, 02467, USA. FAU - Hohenberg, Julie AU - Hohenberg J AD - Department of Computer Science, Boston College, Chestnut Hill, MA, USA. FAU - He, Keshi AU - He K AD - Department of Engineering, Boston College, Chestnut Hill, MA, 02467, USA. FAU - Wei, Donglai AU - Wei D AD - Department of Computer Science, Boston College, Chestnut Hill, MA, USA. FAU - Berhane, Melkamu AU - Berhane M AD - Department of Pediatrics and Child Health, Jimma University, Jimma, Ethiopia. FAU - Girma, Tsinuel AU - Girma T AD - Department of Pediatrics and Child Health, Jimma University, Jimma, Ethiopia. FAU - Estroff, Judy AU - Estroff J AD - Department of Radiology, Boston Children's Hospital, Boston, MA, USA. AD - Harvard Medical School, Boston, MA, USA. FAU - Bell, Katherine A AU - Bell KA AD - Harvard Medical School, Boston, MA, USA. AD - Department of Pediatrics, Brigham & Women's Hospital, Boston, MA, USA. FAU - Park, Jinhee AU - Park J AD - William F. Connell School of Nursing, Boston College, Chestnut Hill, MA, USA. LA - eng PT - Journal Article DEP - 20260406 PL - England TA - Pilot Feasibility Stud JT - Pilot and feasibility studies JID - 101676536 PMC - PMC13188397 OTO - NOTNLM OT - Body composition OT - Malnutrition OT - Newborn and child health OT - Nutritional assessment OT - Pediatrics OT - Ultrasound COIS- Declarations. Ethics approval and consent to participate: Ethical approval has been obtained from the Institutional Review Boards (IRBs) of Boston College, Mass General Brigham (protocol #2023P000325), and Jimma University, as well as the Ethiopian Ministry of Education National Research Ethics Review Committee (protocol #17/242/731/23) to safeguard participant rights throughout the study. Written informed consent will be obtained from the parents or legal guardians of all participants prior to enrollment in the study. All data will be collected and handled in accordance with ethical guidelines to ensure participant confidentiality throughout the study. Consent for publication: Not applicable. The manuscript does not contain individual person's data in any form, including details, images or videos. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/04/06 00:31 MHDA- 2026/04/06 00:32 PMCR- 2026/04/06 CRDT- 2026/04/05 23:45 PHST- 2024/11/22 00:00 [received] PHST- 2026/03/22 00:00 [accepted] PHST- 2026/04/06 00:32 [medline] PHST- 2026/04/06 00:31 [pubmed] PHST- 2026/04/05 23:45 [entrez] PHST- 2026/04/06 00:00 [pmc-release] AID - 10.1186/s40814-026-01814-w [pii] AID - 1814 [pii] AID - 10.1186/s40814-026-01814-w [doi] PST - epublish SO - Pilot Feasibility Stud. 2026 Apr 6;12(1):74. doi: 10.1186/s40814-026-01814-w. PMID- 41937155 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260520 LR - 20260813 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2026 Apr 5 TI - Illness severity, treatment motivation and personality as predictors for the treatment outcome in adolescents and young adults with anorexia nervosa. LID - 10.1186/s40337-026-01598-7 [doi] LID - 121 AB - BACKGROUND: Anorexia nervosa (AN) is a severe psychiatric disorder with high chronicity, particularly affecting adolescents. Existing treatments for adolescents do not always lead to full recovery. Recently, the developmentally adapted Maudsley Model of Anorexia Nervosa Treatment for Adolescents (MANTRa) has emerged as a promising alternative, warranting investigation into its outcome predictors. METHODS: This secondary analysis is based on data from a multi-center cohort study conducted in several Austrian clinical settings. The study included 92 participants aged 13-21 years diagnosed with AN who received MANTRa (n = 45) or treatment-as-usual (TAU, n = 47). Statistical analyses focused on identifying baseline predictors and moderators of treatment success (change in eating disorder symptomatology) for the MANTRa and TAU groups at end-of-treatment and 18-month-follow-up. In addition to univariate linear regression models associating various predictor variables (BMI, eating disorder severity, depressive symptoms, weight suppression, illness duration, age of onset, motivation for change, and personality traits) with the long-term eating disorder outcome, we used a cluster analysis approach to categorize patients into high vs. low illness severity and "favorable" vs. "unfavorable" treatment motivation/personality profiles. Differences between clusters regarding treatment outcome were explored further. RESULTS: In the MANTRa group, none of the examined baseline variables significantly predicted outcomes at 18-month follow-up in univariate models. In contrast, in the TAU group, higher initial eating-disorder psychopathology and lower motivation were associated with poorer outcomes. In MANTRa, there was a trend suggesting that patients with both high and low baseline illness severity, as well as those with unfavorable and favorable motivation/personality profiles, demonstrated sustained symptom reduction. By contrast, in the TAU group, sustained improvements were observed primarily among patients with low baseline illness severity and a favorable motivation/personality profile, whereas those with high illness severity and an unfavorable profile tended to show less benefit. CONCLUSIONS: These results provide preliminary evidence for MANTRa as an effective, individualized treatment for adolescents with AN, including those exhibiting severe pathology, low baseline motivation and personality traits, e.g. low self-directedness, high harm avoidance and low cooperativeness. Future randomized controlled trials comparing MANTRa with established treatments are warranted to validate these findings and refine patient selection criteria. TRIAL REGISTRATION: The original trial was registered at clinicaltrials.gov (Identifier NCT03535714). CI - (c) 2026. The Author(s). FAU - Kopp, Konstantin AU - Kopp K AUID- ORCID: 0000-0003-4841-8118 AD - Eating Disorder Unit, Department for Child and Adolescent Psychiatry, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. FAU - Truttmann, Stefanie AU - Truttmann S AUID- ORCID: 0000-0002-7374-4559 AD - Eating Disorder Unit, Department for Child and Adolescent Psychiatry, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. FAU - Wittek, Tanja AU - Wittek T AUID- ORCID: 0000-0001-7358-4842 AD - Eating Disorder Unit, Department for Child and Adolescent Psychiatry, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. FAU - Klang, Julia AU - Klang J AUID- ORCID: 0000-0003-0992-6865 AD - Eating Disorder Unit, Department for Child and Adolescent Psychiatry, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. FAU - Krauss, Helene AU - Krauss H AD - Eating Disorder Unit, Department for Child and Adolescent Psychiatry, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. FAU - Aichinger, Carina AU - Aichinger C AD - Eating Disorder Unit, Department for Child and Adolescent Psychiatry, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. FAU - Kostner, Isolde AU - Kostner I AD - Eating Disorder Unit, Department for Child and Adolescent Psychiatry, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. FAU - Schmidt, Ulrike AU - Schmidt U AUID- ORCID: 0000-0003-1335-1937 AD - Centre for Research in Eating and Weight Disorders, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. FAU - Karwautz, Andreas AU - Karwautz A AUID- ORCID: 0000-0001-9053-998X AD - Eating Disorder Unit, Department for Child and Adolescent Psychiatry, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. FAU - Zeiler, Michael AU - Zeiler M AUID- ORCID: 0000-0002-7087-6134 AD - Eating Disorder Unit, Department for Child and Adolescent Psychiatry, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. FAU - Wagner, Gudrun AU - Wagner G AUID- ORCID: 0000-0002-4845-9684 AD - Eating Disorder Unit, Department for Child and Adolescent Psychiatry, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria. gudrun.wagner@meduniwien.ac.at. LA - eng SI - ClinicalTrials.gov/NCT03535714 GR - MR/W002418/1/National Institute for Health Research (NIHR) Biomedical Research Centre (BRC) at South London and Maudsley NHS Foundation Trust (SLaM) and King's College London (KCL) and the Medical Research Counci/ GR - 99901006800/Gemeinsame Gesundheitsziele-Pharma Master Agreement/ PT - Journal Article DEP - 20260405 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC13188742 OAB - Anorexia nervosa is a serious mental illness that often begins during adolescence and can be difficult to treat. Although several therapies are available, many young people do not achieve full recovery. The MANTRa program is a newer, age-adapted treatment that focuses on helping patients understand and change the thoughts and behaviors that keep the illness going. This study looked at 92 adolescents and young adults with anorexia nervosa who received either MANTRa or standard treatment in Austrian clinics. We examined which factors at the start of treatment could predict how well patients recovered over time. We found that, unlike in standard treatment, symptom severity prior to treatment start and motivation did not predict outcomes in the MANTRa group. Patients treated with MANTRa, including those with high illness severity and low treatment motivation, continued to improve up to 18 months after treatment, while progress in the standard treatment group leveled off. These results suggest that MANTRa may be particularly helpful for young people with more severe symptoms or lower initial motivation. OABL- eng OTO - NOTNLM OT - Adolescents OT - Character OT - Eating disorders OT - MANTRa OT - Motivation for change OT - Motivational interviewing OT - Outcome moderators OT - Psychotherapy OT - Temperament COIS- Declarations. Ethics approval and consent to participate: Ethical approval for the original studies was obtained from the Ethics Committee of the Medical University of Vienna (EK 2005/2017), and all participants (and legal guardians for those under 18) provided written informed consent. Competing interests: The authors declare no competing interests. Competing interests: The authors declare no conflicts of interest. EDAT- 2026/04/06 00:30 MHDA- 2026/04/06 00:31 PMCR- 2026/04/05 CRDT- 2026/04/05 23:43 PHST- 2025/12/02 00:00 [received] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/04/06 00:31 [medline] PHST- 2026/04/06 00:30 [pubmed] PHST- 2026/04/05 23:43 [entrez] PHST- 2026/04/05 00:00 [pmc-release] AID - 10.1186/s40337-026-01598-7 [pii] AID - 1598 [pii] AID - 10.1186/s40337-026-01598-7 [doi] PST - epublish SO - J Eat Disord. 2026 Apr 5;14(1):121. doi: 10.1186/s40337-026-01598-7. PMID- 41936708 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20261010 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 5 DP - 2026 Apr 6 TI - Association of peripheral muscle mass and in-hospital mortality in mechanically ventilated critically ill children: a prospective observational study. LID - 236 [pii] LID - 10.1007/s00431-026-06799-5 [doi] AB - Early muscle wasting in critically ill children during pediatric intensive care unit (PICU) admission correlates with poor clinical outcomes. This study aims to evaluate the predictive capability of ultrasound-measured loss rates in the biceps brachii (BB) and rectus femoris (RF) muscles for in-hospital mortality in pediatric patients. This is a single-center, prospective, observational study conducted from July 12, 2025, to October 22, 2025. It included children aged 1 month to < 18 years admitted to the PICU who required mechanical ventilation for at least 48 h. Ultrasound measurements were performed within 24 h of PICU admission (baseline) and on days 3, 5, and 7. Measurements included thickness and cross-sectional area (CSA) of the BB and RF. A total of 86 children were included. Analysis was performed on 86, 81, and 67 children at days 3, 5, and 7 of PICU admission, respectively. Continuous loss of BB and RF muscle mass occurred during the first week of PICU admission in critically ill children. Among children who died during hospitalization, RF CSA on days 3, 5, and 7, and BB CSA on day 3, showed greater decreases from baseline compared to the survivor group (p < 0.05). RF CSA loss >/= 17.62% on day 5 demonstrated the highest predictive capability for in-hospital mortality, with an area under the receiver operating characteristic (AUROC) curve of 0.761 (0.645, 0.877), sensitivity of 72.2%, and specificity of 71.4%. The RF CSA < 17.62% on day 5 was associated with lower in-hospital mortality, with an adjusted hazard ratio (HR) of 0.076 (95% CI 0.014, 0.395, p = 0.002). CONCLUSIONS: During the first week of admission to the PICU, children experience continuous muscle wasting. Greater muscle loss correlates with poorer outcomes, and the rate of RF CSA loss on day 5 demonstrates good predictive capability for in-hospital mortality. Ultrasound-based muscle assessment helps identify children at higher risk of adverse in-hospital outcomes. WHAT'S KNOWN: * Early muscle wasting is a key prognostic risk factor in critically ill children. * Bedside ultrasound serves as a reliable tool for dynamic monitoring of muscle wasting. WHAT IS NEW: * This study quantifies the trajectory and magnitude of peripheral muscle wasting using serial ultrasound in mechanically ventilated children during the first PICU week, identifying a loss of >/= 17.62% in rectus femoris cross-sectional area by day 5 as the strongest predictor of in-hospital mortality. * Early ultrasound monitoring provides an objective, bedside measure that may offer prognostic information alongside traditional severity scores. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Cai, Ye AU - Cai Y AD - Pediatric Intensive Care Unit, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing, China. FAU - Zhang, Qiaoying AU - Zhang Q AD - Pediatric Intensive Care Unit, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing, China. FAU - Meng, Yuqian AU - Meng Y AD - Pediatric Intensive Care Unit, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing, China. FAU - He, Shan AU - He S AD - Pediatric Intensive Care Unit, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Children and Adolescents' Health and Diseases, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases, Chongqing, China. FAU - Yang, Yun AU - Yang Y AD - Department of Gastroenterology, Children's Hospital of Chongqing Medical University, Chongqing, China. 1372205999@qq.com. LA - eng PT - Journal Article PT - Observational Study DEP - 20260406 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Male MH - Prospective Studies MH - *Critical Illness/mortality MH - Female MH - Child, Preschool MH - Infant MH - *Hospital Mortality MH - *Respiration, Artificial MH - Ultrasonography MH - Intensive Care Units, Pediatric MH - Child MH - Adolescent MH - *Quadriceps Muscle/diagnostic imaging MH - *Muscular Atrophy/mortality/diagnostic imaging MH - Predictive Value of Tests MH - ROC Curve MH - *Muscle, Skeletal/diagnostic imaging MH - Prognosis OTO - NOTNLM OT - Cross-sectional area OT - Intensive care unit OT - Mortality OT - Muscle thickness OT - Pediatrics OT - Ultrasound COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/04/06 00:31 MHDA- 2026/04/06 00:32 CRDT- 2026/04/05 23:15 PHST- 2025/11/08 00:00 [received] PHST- 2026/02/10 00:00 [accepted] PHST- 2026/02/03 00:00 [revised] PHST- 2026/04/06 00:32 [medline] PHST- 2026/04/06 00:31 [pubmed] PHST- 2026/04/05 23:15 [entrez] AID - 10.1007/s00431-026-06799-5 [pii] AID - 10.1007/s00431-026-06799-5 [doi] PST - epublish SO - Eur J Pediatr. 2026 Apr 6;185(5):236. doi: 10.1007/s00431-026-06799-5. PMID- 41935198 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Apr 4 TI - Application of machine learning algorithm for predicting acute malnutrition among under 5 children in east Africa using recent DHS. LID - 10.1038/s41598-026-46944-6 [doi] LID - 16242 AB - Acute malnutrition remains a critical public health challenge across East Africa, contributing substantially to under-five morbidity and mortality. Early identification of at-risk children using predictive models could enhance timely intervention. This study aimed to develop and evaluate machine learning models for predicting acute malnutrition among under-five children in East Africa. A cross-sectional analysis was conducted using the most recent DHS data from 12 East African countries. A total of 76,224 children under-five years were included. Data preprocessing involved multiple imputation for missing values, one-hot encoding for categorical variables, SMOTE to address class imbalance, and multiple feature selection. ten supervised machine learning algorithms; Logistic Regression, Random Forest, K-Nearest Neighbors, Decision Tree, Support Vector Machine, Naive Bayes, XGBoost, LightGBM, CatBoost, and Stochastic Gradient Descent were trained and evaluated using an 80/20 train-test split and stratified five-fold cross-validation. Model performance was assessed using accuracy, AUC, precision, recall, and F1-score, and interpretability was explored using SHapley Additive exPlanations (SHAP). The overall prevalence of acute malnutrition across east Africa was 6.08% (95% CI 5.91-6.25%), ranging from 1.2% in Rwanda to 12.27% in Ethiopia. The Random Forest algorithm demonstrated the best predictive performance, achieving an AUC of 74.6% (95% CI 73.0-76.2), accuracy of 71.2%, precision of 13.1%, recall of 66.2%, specificity of 71.5%, and an F1-score of 0.218. SHAP analysis identified important predictors of acute malnutrition as rural residence, large family size (>/= 6 members), higher number of under-five children (>/= 3), small or very small birth size, inadequate antenatal care, unimproved water sources, inappropriate disposal of child feces, recent diarrheal illness, and lack of latrine facilities. Protective factors included maternal literacy, antenatal care attendance, vitamin A supplementation, longer birth intervals (>/= 2 years), and maternal employment. Random Forest, demonstrate superior predictive capacity for identifying children at risk of acute malnutrition in East Africa. The integration of such models into national nutrition surveillance systems could enable early detection and targeted interventions. Strategies should prioritize rural communities, strengthen maternal education and empowerment, improve water and sanitation infrastructure, and antenatal care to mitigate risk factors and enhance child nutritional outcomes. CI - (c) 2026. The Author(s). FAU - Feleke, Habtamu Guaguahu AU - Feleke HG AD - Department of Public Health, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia. guaguahuhabtamu@gmail.com. FAU - Simegn, Mulat Belay AU - Simegn MB AD - Department of Public Health, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia. FAU - Gebreegziabher, Zenebe Abebe AU - Gebreegziabher ZA AD - Department of Epidemiology and Biostatistics, School of Public Health, Asrat Woldeyes Health Sciences Campus, Debre Berhan University, Debre Berhan, Ethiopia. FAU - Mazengia, Elyas Melaku AU - Mazengia EM AD - Department of Public Health, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia. FAU - Tilahun, Werkneh Melkie AU - Tilahun WM AD - Department of Public Health, College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia. LA - eng PT - Journal Article DEP - 20260404 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Africa, Eastern/epidemiology MH - *Machine Learning MH - Child, Preschool MH - Female MH - Boosting Machine Learning Algorithms MH - Predictive Learning Models MH - *Malnutrition/epidemiology/diagnosis MH - Classification Algorithms MH - Random Forest MH - Male MH - Prediction Algorithms MH - Cross-Sectional Studies MH - Infant MH - Algorithms MH - East African People MH - Prevalence MH - Logistic Models PMC - PMC13201603 OTO - NOTNLM OT - Acute malnutrition OT - Children OT - East Africa OT - Machine learning OT - Prediction COIS- Declarations. Ethical approval: The Study was a secondary data analysis based on publicly accessible DHS database and after we asked the MEASURE DHS Program for the data, and we were given permission to download and utilize it. All analyses were conducted in compliance with the DHS data use guidelines to maintain the privacy and rights of the survey participants. The consents are available at https://www.dhsprogram.com/methodology/Protecting-the-Privacy-of-DHS-Survey-Respondents.cfm . Competing interests: The authors declare no competing interests. EDAT- 2026/04/05 04:22 MHDA- 2026/05/26 00:31 PMCR- 2026/04/04 CRDT- 2026/04/04 23:17 PHST- 2025/11/14 00:00 [received] PHST- 2026/03/28 00:00 [accepted] PHST- 2026/05/26 00:31 [medline] PHST- 2026/04/05 04:22 [pubmed] PHST- 2026/04/04 23:17 [entrez] PHST- 2026/04/04 00:00 [pmc-release] AID - 10.1038/s41598-026-46944-6 [pii] AID - 46944 [pii] AID - 10.1038/s41598-026-46944-6 [doi] PST - epublish SO - Sci Rep. 2026 Apr 4;16(1):16242. doi: 10.1038/s41598-026-46944-6. PMID- 41934789 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260718 IS - 1532-2238 (Electronic) IS - 1096-6374 (Linking) VI - 84 DP - 2026 Jun TI - Low IGF-1 combined with a single clonidine stimulation test as a confirmatory tool for pediatric growth hormone deficiency. PG - 101698 LID - S1096-6374(26)00020-1 [pii] LID - 10.1016/j.ghir.2026.101698 [doi] AB - BACKGROUND: Growth hormone deficiency (GHD) in children is a complex endocrine disorder that requires dynamic testing for accurate diagnosis due to the pulsatile nature of growth hormone (GH) secretion. The clonidine test is widely used as a standard diagnostic tool due to its favorable safety profile and effectiveness. Insulin-like growth factor-1 (IGF-1) has emerged as a potential adjunct marker; however, its diagnostic accuracy is limited when used alone. This study aims to evaluate the diagnostic effectiveness of combining low IGF-1 with a single clonidine stimulation test for diagnosing pediatric GHD. METHODS: A retrospective cohort study was conducted at King Chulalongkorn Memorial Hospital, including 214 children with short stature (aged 2-16 years) evaluated between August 2019 and January 2025. GHD was confirmed in 63 patients using two GH stimulation tests (peak GH <7 ng/mL). Serum IGF-1 levels were expressed as standard deviation scores (SDS) and analyzed at cutoff points of /= 1.84 was associated with amenorrhoea, hospitalisation need at admission, hypotension, bradycardia, hypothermia, and leucopenia. Higher AGR predicted rehospitalisation during follow-up and longer menstrual resumption duration. CONCLUSION: Unlike other chronic conditions, a higher AGR at presentation was associated with both greater medical disease severity and poorer prognosis in adolescents with AN and AAN, possibly due to relatively preserved albumin alongside decreased globulin. CI - (c) 2026 The Author(s). European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd. FAU - Kalkan, Eylem Serife AU - Kalkan ES AUID- ORCID: 0000-0001-5617-7778 AD - Division of Adolescent Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkiye. FAU - Baklaci, Ayse Bilge AU - Baklaci AB AUID- ORCID: 0000-0003-4602-1993 AD - Division of Adolescent Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkiye. FAU - Kilic, Yelda AU - Kilic Y AUID- ORCID: 0009-0007-9153-6060 AD - Division of Adolescent Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkiye. FAU - Akgul, Sinem AU - Akgul S AUID- ORCID: 0000-0001-8203-2337 AD - Division of Adolescent Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkiye. FAU - Ozgul, Nilgun AU - Ozgul N AUID- ORCID: 0000-0003-0331-9044 AD - Department of Statistics, Hacettepe University, Ankara, Turkiye. FAU - Pehlivanturk Kizilkan, Melis AU - Pehlivanturk Kizilkan M AUID- ORCID: 0000-0002-0637-050X AD - Division of Adolescent Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260404 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 RN - 0 (Serum Albumin) RN - 0 (Serum Globulins) RN - 0 (Biomarkers) SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Anorexia Nervosa/blood/diagnosis MH - Prognosis MH - Retrospective Studies MH - *Serum Albumin/metabolism MH - *Serum Globulins/metabolism MH - Severity of Illness Index MH - Biomarkers/blood PMC - PMC13432581 OTO - NOTNLM OT - albumin-globulin ratio OT - anorexia nervosa OT - atypical anorexia nervosa OT - disease severity OT - prognosis COIS- The authors declare conflicts to declare. EDAT- 2026/04/05 04:20 MHDA- 2026/08/03 18:37 PMCR- 2026/08/03 CRDT- 2026/04/04 08:33 PHST- 2026/03/18 00:00 [revised] PHST- 2026/02/10 00:00 [received] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/08/03 18:37 [medline] PHST- 2026/04/05 04:20 [pubmed] PHST- 2026/04/04 08:33 [entrez] PHST- 2026/08/03 00:00 [pmc-release] AID - ERV70106 [pii] AID - 10.1002/erv.70106 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2026 Sep;34(5):1193-1208. doi: 10.1002/erv.70106. Epub 2026 Apr 4. PMID- 41933946 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260803 IS - 1878-1861 (Electronic) IS - 1878-1861 (Linking) VI - 29 IP - 9 DP - 2026 Aug TI - Development of a machine learning model to detect toddlers' physical activity and sedentary time using accelerometers: Little Movers Activity Analysis. PG - 1015-1023 LID - S1440-2440(26)00103-9 [pii] LID - 10.1016/j.jsams.2026.03.009 [doi] AB - OBJECTIVES: Toddler movement patterns challenge current accelerometer-based detection of physical activity (PA) and sedentary time (SED). The objectives of this study were to: (1) develop a novel machine learning (ML) model to detect toddlers' PA and SED; and (2) compare this ML model to existing cut-point methods to analyze toddlers' PA (independent sample cross-validation of existing methods). DESIGN AND METHODS: We recruited 111 toddlers (21 +/- 7 months; 51% female) to two 1-hour semi-structured visits wearing a waist-worn ActiGraph wGT3X-BT accelerometer. Video recordings were manually annotated using a modified Children's Activity Rating Scale to determine a ground truth. We extracted 40 time and frequency domain features from raw accelerations and trained 4 gradient boosted tree ML models (distinguishing SED, total PA (TPA), light PA (LPA), moderate-to-vigorous PA (MVPA), and non-volitional movement (NVM)). Models were assessed using accuracy, F1 scores, and confusion matrices. For the validation of 11 existing methods, we calculated accuracy, F1, and mean absolute differences in TPA and MVPA estimation. RESULTS: ML models classifying NVM/SED/TPA and NVM/SED/LPA/MVPA reached 82% and 74% accuracy with mean absolute differences of 3.0 and 3.2 min/h, respectively. Independent sample cross-validation found accuracies from 33 to 74% and mean absolute differences from 7.6 to 18.6 min/h in TPA and 10.7 to 25.8 min/h in MVPA. CONCLUSIONS: We recommend the NVM/SED/TPA or NVM/SED/LPA/MVPA models' given alignment with toddler TPA guidelines and MVPA link to health outcomes, respectively. We additionally present an open-access interface for using these ML models that does not require coding knowledge. This presents a substantial step forward in the measurement of toddlers' physical activity. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Letts, Elyse AU - Letts E AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Canada. FAU - King-Dowling, Sara AU - King-Dowling S AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Canada; Department of Pediatrics, The Children's Hospital of Philadelphia, United States of America. FAU - Di Cristofaro, Natascja AU - Di Cristofaro N AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Canada. FAU - Tucker, Patricia AU - Tucker P AD - School of Occupational Therapy, Western University, Canada; Children's Health Research Institute, Canada. FAU - Cairney, John AU - Cairney J AD - School of Human Movement and Nutrition Sciences, Health and Well-Being Centre for Research Innovation, Queensland Centre for Olympic and Paralympic Studies, University of Queensland, Australia. FAU - Kobsar, Dylan AU - Kobsar D AD - Department of Kinesiology, Faculty of Science, McMaster University, Canada. FAU - Timmons, Brian W AU - Timmons BW AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Canada; Department of Kinesiology, Faculty of Science, McMaster University, Canada. FAU - Obeid, Joyce AU - Obeid J AD - Child Health & Exercise Medicine Program, Department of Pediatrics, McMaster University, Canada; Department of Kinesiology, Faculty of Science, McMaster University, Canada. Electronic address: obeidj@mcmaster.ca. LA - eng PT - Journal Article DEP - 20260318 PL - Australia TA - J Sci Med Sport JT - Journal of science and medicine in sport JID - 9812598 SB - IM MH - Humans MH - *Sedentary Behavior MH - Female MH - *Accelerometry/methods MH - *Machine Learning MH - Infant MH - *Exercise MH - Child, Preschool MH - Male MH - Predictive Learning Models MH - Boosting Machine Learning Algorithms OTO - NOTNLM OT - Accelerometry OT - Actigraphy OT - Early years OT - Gradient boosted trees OT - Sedentary behavior OT - Trees COIS- Declaration of interest statement None. The authors declare no conflicts of interest. EDAT- 2026/04/04 06:33 MHDA- 2026/08/04 00:35 CRDT- 2026/04/04 02:10 PHST- 2025/10/01 00:00 [received] PHST- 2026/01/15 00:00 [revised] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/08/04 00:35 [medline] PHST- 2026/04/04 06:33 [pubmed] PHST- 2026/04/04 02:10 [entrez] AID - S1440-2440(26)00103-9 [pii] AID - 10.1016/j.jsams.2026.03.009 [doi] PST - ppublish SO - J Sci Med Sport. 2026 Aug;29(9):1015-1023. doi: 10.1016/j.jsams.2026.03.009. Epub 2026 Mar 18. PMID- 41933704 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 2156-5376 (Electronic) IS - 2161-8313 (Print) IS - 2161-8313 (Linking) VI - 17 IP - 5 DP - 2026 May TI - Saliva as a Matrix for Primary Care: Feasibility and Scoping of Its Use for Assessment of Nutrition and Inflammation. PG - 100625 LID - S2161-8313(26)00039-6 [pii] LID - 10.1016/j.advnut.2026.100625 [doi] LID - 100625 AB - Scarce laboratory capacity constrains both primary care and population surveillance for nutritional and inflammation assessment globally. One major contributing factor is the reliance on blood as the primary matrix, and its associated limitations of being invasive, having relatively lower acceptance in apparently healthy individuals and community settings, and being heavily dependent on laboratory and related infrastructure. Saliva offers a noninvasive, inexpensive, and more convenient alternative that causes less discomfort and has the potential to expand the portfolio of point-of-care testing for nutrition and inflammation assessment in primary care. We aimed to synthesize the evidence on the feasibility and scope of using salivary biomarkers for nutrition and inflammation assessment. A literature search was conducted in MEDLINE and CINAHL, without restrictions on language, geographical location, or publication date. Screening and data extraction were done in duplicate on Covidence. A narrative synthesis was done to summarize the results. Seventy-six studies examining salivary biomarkers for nutrition and inflammation were identified across 26 countries, involving 5425 children and 5617 adults. We summarized the results from 33 studies assessing ferritin, iron, zinc, calcium, vitamin A, vitamin B-12, vitamin D, vitamin C, and vitamin E in saliva. Additionally, we found 43 studies evaluating salivary inflammatory biomarkers, including C-reactive protein, alpha-1 acid glycoprotein, hepcidin, immunoglobulin A, and cytokines within the context of nutritional impairments. Although most biomarker values were detectable in saliva, significant evidence and methodological gaps remain, including the absence of standardized protocols for sample collection, transportation, processing, storage, and laboratory analysis; insufficient information on diagnostic performance, accuracy, and comparability with corresponding blood biomarkers; and challenges in interpreting findings across different population subsets and settings. Future research should focus on improving method reporting and ensuring the clinical relevance of findings to maximize the potential of saliva-based diagnostics for nutrition and inflammation assessment. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Fahim, Shah Mohammad AU - Fahim SM AD - Cornell Joan Klein Jacobs Center for Precision Nutrition and Health, Cornell University, Ithaca, NY, United States; Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Miah, Mahesa AU - Miah M AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Marcotte, Mia AU - Marcotte M AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Zoria, Nancy AU - Zoria N AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Ahmed, Mahdia AU - Ahmed M AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Huey, Samantha L AU - Huey SL AD - Cornell Joan Klein Jacobs Center for Precision Nutrition and Health, Cornell University, Ithaca, NY, United States; Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States. FAU - Erickson, David AU - Erickson D AD - Cornell Joan Klein Jacobs Center for Precision Nutrition and Health, Cornell University, Ithaca, NY, United States; Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States; Sibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY, United States; NIH Center for Point-of-Care Diagnostics for Nutrition, Infection, and Cancer for Global Health (PORTENT), Cornell University, Ithaca, NY, United States. FAU - Finkelstein, Julia L AU - Finkelstein JL AD - Cornell Joan Klein Jacobs Center for Precision Nutrition and Health, Cornell University, Ithaca, NY, United States; Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States; NIH Center for Point-of-Care Diagnostics for Nutrition, Infection, and Cancer for Global Health (PORTENT), Cornell University, Ithaca, NY, United States; Division of Epidemiology, Department of Population Health Sciences, Cornell Weill Medicine, New York, NY, United States. FAU - Mehta, Saurabh AU - Mehta S AD - Cornell Joan Klein Jacobs Center for Precision Nutrition and Health, Cornell University, Ithaca, NY, United States; Division of Nutritional Sciences, Cornell University, Ithaca, NY, United States; NIH Center for Point-of-Care Diagnostics for Nutrition, Infection, and Cancer for Global Health (PORTENT), Cornell University, Ithaca, NY, United States; Division of Epidemiology, Department of Population Health Sciences, Cornell Weill Medicine, New York, NY, United States. Electronic address: smehta@cornell.edu. LA - eng PT - Journal Article PT - Review DEP - 20260401 PL - United States TA - Adv Nutr JT - Advances in nutrition (Bethesda, Md.) JID - 101540874 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Saliva/chemistry MH - Biomarkers/analysis MH - *Inflammation/diagnosis/metabolism MH - *Primary Health Care MH - *Nutrition Assessment MH - *Nutritional Status MH - Feasibility Studies MH - Child MH - Point-of-Care Testing MH - Adult PMC - PMC13112399 OTO - NOTNLM OT - biomarkers OT - cytokines OT - nutrition assessment OT - nutritional status OT - point of care OT - saliva COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/04/04 06:33 MHDA- 2026/05/17 06:29 PMCR- 2026/04/01 CRDT- 2026/04/04 01:20 PHST- 2025/11/17 00:00 [received] PHST- 2026/03/23 00:00 [revised] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/05/17 06:29 [medline] PHST- 2026/04/04 06:33 [pubmed] PHST- 2026/04/04 01:20 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - S2161-8313(26)00039-6 [pii] AID - 100625 [pii] AID - 10.1016/j.advnut.2026.100625 [doi] PST - ppublish SO - Adv Nutr. 2026 May;17(5):100625. doi: 10.1016/j.advnut.2026.100625. Epub 2026 Apr 1. PMID- 41933386 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1750-1172 (Electronic) IS - 1750-1172 (Linking) VI - 21 IP - 1 DP - 2026 Apr 3 TI - Attenuated dietary motivation in Wilson's disease correlates with clinical severity. LID - 10.1186/s13023-026-04263-z [doi] LID - 130 AB - BACKGROUND & AIMS: Wilson's disease (WD) necessitates lifelong copper-chelation therapy and a restrictive low-copper diet. While the psychological impact of dietary restriction is well-documented in obesity and diabetes, the distinctive eating psychology of WD patients remains unexplored. We aimed to characterize the eating psychology of WD patients and its association with disease severity. METHODS: In a cross-sectional study, 50 WD inpatients and 110 HCs were assessed using the Food Cravings Questionnaire-Trait (FCQ-T) and the Dutch Eating Behavior Questionnaire (DEBQ). WD patients were stratified by liver function, neurological symptoms, and platelet-to-white blood cell ratio (PWR), and prevalent ATP7B genotype (R778L). Group comparisons used non-parametric tests. RESULTS: Compared to HCs, WD patients showed significantly lower scores on all DEBQ dimensions and key FCQ-T facets (all p<0.05). Within the WD cohort, patients with milder liver disease (CTP-A) or no neurological symptoms had significantly higher scores on emotion-driven craving and food-related reinforcement than those with advanced disease (CTP-B/C) or neurological involvement (p<0.05). A low PWR, indicative of severe liver fibrosis, was associated with significantly reduced "Thoughts about food" (U=396.5, p=0.028). Exploratory analysis based on the R778L mutation revealed no significant association between genotype and dietary psychological scores. CONCLUSIONS: WD is associated with a generally attenuated dietary motivation; however, patients with less severe disease exhibit a characteristic psychological profile with relatively stronger reward-related eating motivations compared to their more severely affected counterparts. These findings highlight the need for integrated psychometric assessment in WD management to guide personalized dietary interventions and improve outcomes. CI - (c) 2026. The Author(s). FAU - Wang, Xue-Qiao AU - Wang XQ AD - Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei, Anhui, 230031, China. FAU - Wang, Yan-Xin AU - Wang YX AD - Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei, Anhui, 230031, China. 2197878957@qq.com. FAU - Ye, Zhao-Hao AU - Ye ZH AD - Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei, Anhui, 230031, China. FAU - Zhang, Zhi-Lin AU - Zhang ZL AD - Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei, Anhui, 230031, China. FAU - Pan, Xun AU - Pan X AD - Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei, Anhui, 230031, China. FAU - Wang, Xi-Chen AU - Wang XC AD - Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei, Anhui, 230031, China. FAU - Cen, Si-Fan AU - Cen SF AD - Department of Neurology, The First Affiliated Hospital of Anhui University of Chinese Medicine, No. 117 Meishan Road, Hefei, Anhui, 230031, China. LA - eng PT - Journal Article DEP - 20260403 PL - England TA - Orphanet J Rare Dis JT - Orphanet journal of rare diseases JID - 101266602 SB - IM MH - Humans MH - Female MH - Male MH - *Hepatolenticular Degeneration/psychology/physiopathology/genetics/pathology MH - Adult MH - Cross-Sectional Studies MH - *Motivation/physiology MH - Surveys and Questionnaires MH - Feeding Behavior/physiology MH - Adolescent MH - Young Adult MH - Middle Aged MH - Diet PMC - PMC13049706 OTO - NOTNLM OT - Dutch eating behavior questionnaire OT - Eating psychology OT - Low-copper diet OT - PWR OT - Reward motivation OT - Wilson's disease COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the Ethics Committee of The First Affiliated Hospital of Anhui University of Chinese Medicine and was conducted in accordance with the ethical principles of the Declaration of Helsinki. All participants provided written informed consent. Consent for publication: All authors have read and approved the final manuscript and give their consent for publication. Conflict of interest: The first author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Generative AI statement: The first author declares that no Generative AI was used in the creation of this manuscript. EDAT- 2026/04/04 00:36 MHDA- 2026/04/04 06:34 PMCR- 2026/04/03 CRDT- 2026/04/03 23:50 PHST- 2025/10/07 00:00 [received] PHST- 2026/02/05 00:00 [accepted] PHST- 2026/04/04 06:34 [medline] PHST- 2026/04/04 00:36 [pubmed] PHST- 2026/04/03 23:50 [entrez] PHST- 2026/04/03 00:00 [pmc-release] AID - 10.1186/s13023-026-04263-z [pii] AID - 4263 [pii] AID - 10.1186/s13023-026-04263-z [doi] PST - epublish SO - Orphanet J Rare Dis. 2026 Apr 3;21(1):130. doi: 10.1186/s13023-026-04263-z. PMID- 41933301 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1471-2334 (Electronic) IS - 1471-2334 (Linking) VI - 26 IP - 1 DP - 2026 Apr 3 TI - Risk factors for carbapenem-resistant Acinetobacter baumannii infection in children and A. baumannii-related mortality in the PICU: a retrospective study in Guangxi, China. LID - 10.1186/s12879-026-13219-4 [doi] LID - 955 AB - BACKGROUND: Carbapenem-resistant Acinetobacter baumannii (CRAB) is recognized as a critical-priority pathogen due to the considerable therapeutic difficulties it poses and its association with high mortality. Pediatric patients are particularly vulnerable to the adverse clinical outcomes of these infections. METHODS: This retrospective study analyzed the clinical and microbiological characteristics of patients at the Maternal and Child Health Hospital of Guangxi, China, between January 2019 and December 2025. It further assessed risk factors for both CRAB infection and A. baumannii-related mortality in the pediatric intensive care unit (PICU). Univariate and multivariate logistic regression analyses were performed to identify independent risk factors. A predictive model was then developed, and its performance was evaluated using the Hosmer-Lemeshow goodness-of-fit test and receiver operating characteristic (ROC) curve analysis. RESULTS: The study included a total of 436 children, comprising 222 with CRAB infection and 214 with carbapenem-susceptible A. baumannii (CSAB) infection. In the univariate analysis, potential risk factors for CRAB infection (P < 0.05) included younger age, prior hospitalization, PICU admission, specific infections (enteritis, pneumonia, bloodstream infections), the use of invasive procedures or devices (mechanical ventilation, indwelling urethral catheters, central venous catheters, drainage tubes, parenteral nutrition, nasogastric feeding tubes), and prior exposure to glycopeptides, oxazolidinones, carbapenems, and corticosteroids. Potential risk factors for A. baumannii-related mortality in PICU (P < 0.05) included prior hospitalization, tumor, CRAB infection, septic shock, use of indwelling urethral or central venous catheters, parenteral nutrition, prior exposure to beta-lactam-beta-lactamase inhibitors, carbapenems, tetracyclines, trimethoprim-sulfamethoxazole, or corticosteroids, as well as levels of platelet (PLT) count, C-reactive protein (CRP), albumin (ALB), and alanine aminotransferase (ALT) levels. Subsequently, multivariate logistic regression model analysis identified admission to the PICU (Odds Ratio (OR): 5.136, 95% CI: 3.045-8.661, P < 0.001), pneumonia (OR: 2.618, 95% CI: 1.384-4.954, P = 0.003), carbapenems exposure (OR: 3.876, 95% CI: 2.277-6.598, P < 0.001), and prior corticosteroid exposure (OR: 1.860, 95% CI: 1.168-2.961, P = 0.009) as an independent risk factor for CRAB infection. In addition, the independent risk factors for A. baumannii-related mortality in PICU were prior hospitalization (OR: 3.656, 95% CI: 1.808-7.392; P < 0.001), CRAB infection (OR: 3.186, 95% CI: 1.406-7.219; P = 0.006), septic shock (OR: 3.417, 95% CI: 1.440-8.107; P = 0.005), parenteral nutrition (OR: 3.105, 95% CI: 1.248-7.725; P = 0.015), and decreased PLT count (OR: 0.997, 95% CI: 0.995-0.999; P = 0.001). CONCLUSION: Two logistic regression models were developed to predict CRAB infection in children and A. baumannii-related mortality among PICU patients, respectively. The findings highlight the importance of early identification and management of these risk factors. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2026. The Author(s). FAU - Liu, Minxue AU - Liu M AD - Department of Laboratory Medicine, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530003, People's Republic of China. FAU - Huang, Zhan AU - Huang Z AD - Department of Laboratory Medicine, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530003, People's Republic of China. FAU - Huang, Liying AU - Huang L AD - Department of Laboratory Medicine, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530003, People's Republic of China. FAU - Yan, Chenglan AU - Yan C AD - Department of Laboratory Medicine, Children's Hospital, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530003, People's Republic of China. 354143288@qq.com. LA - eng GR - Z-A20220265/self-funded project of the Health Commission of Guangxi Zhuang Autonomous Region/ GR - Z20210134/self-funded project of the Health Commission of Guangxi Zhuang Autonomous Region/ PT - Journal Article DEP - 20260403 PL - England TA - BMC Infect Dis JT - BMC infectious diseases JID - 100968551 RN - 0 (Carbapenems) RN - 0 (Anti-Bacterial Agents) SB - IM MH - Humans MH - Retrospective Studies MH - *Acinetobacter baumannii/drug effects MH - Risk Factors MH - China/epidemiology MH - Female MH - *Carbapenems/pharmacology/therapeutic use MH - Male MH - Intensive Care Units, Pediatric/statistics & numerical data MH - *Acinetobacter Infections/mortality/microbiology/drug therapy/epidemiology MH - Child, Preschool MH - *Anti-Bacterial Agents/pharmacology/therapeutic use MH - Infant MH - Child PMC - PMC13173800 OTO - NOTNLM OT - Acinetobacter baumannii OT - CRAB OT - Children OT - Mortality OT - PICU OT - Risk factors COIS- Declarations. Ethics approval and consent to participate: This study was approved by the local Ethics Committee of The Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region (No.2021-3-50). As the participants were children, their guardians have given informed consent on the participants' behalf before the start of the study. All procedures performed in this study were in line with the principles of the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/04 00:36 MHDA- 2026/05/14 06:51 PMCR- 2026/04/03 CRDT- 2026/04/03 23:44 PHST- 2026/01/27 00:00 [received] PHST- 2026/03/30 00:00 [accepted] PHST- 2026/05/14 06:51 [medline] PHST- 2026/04/04 00:36 [pubmed] PHST- 2026/04/03 23:44 [entrez] PHST- 2026/04/03 00:00 [pmc-release] AID - 10.1186/s12879-026-13219-4 [pii] AID - 13219 [pii] AID - 10.1186/s12879-026-13219-4 [doi] PST - epublish SO - BMC Infect Dis. 2026 Apr 3;26(1):955. doi: 10.1186/s12879-026-13219-4. PMID- 41933233 OWN - NLM STAT- In-Process LR - 20260813 IS - 1875-8312 (Electronic) IS - 1569-5794 (Print) IS - 1569-5794 (Linking) VI - 42 IP - 8 DP - 2026 Aug TI - ‌Coronary inflammatory imaging and clinical factors: associations with coronary artery aneurysm regression in pediatric Kawasaki disease. PG - 1545-1554 LID - 10.1007/s10554-026-03701-0 [doi] AB - The factors influencing the regression of coronary artery aneurysms (CAAs) in Kawasaki disease (KD) remain incompletely understood. Recent studies suggest a potential role for coronary inflammation and fat attenuation index (FAI) of perivascular adipose tissue attenuation (PCAT) derived from coronary computed tomography angiography (CCTA). This study aimed to investigate the differences in clinical, laboratory, and imaging characteristics, with a focus on pericoronary adipose tissue FAI, between patients with CAAs regression and non-regression. In this retrospective observational study, children diagnosed with Kawasaki disease accompanied by coronary artery involvement were divided into a Regression group and a Non-Regression group based on the outcome of coronary aneurysm progression. Baseline demographic, clinical, and laboratory data were collected and were comparable between groups. Key imaging parameters assessed included the maximum CAA diameter, Z-score, CAA size category (small, medium, giant), and the pericoronary fat attenuation index (FAI) measured by coronary computed tomography angiography (CCTA). Multivariable logistic regression was used to identify independent predictors of CAA regression. This retrospective observational study analyzed 40 KD patients with documented CAAs, divided into a Regression group (R group, n = 20) and a Non-Regression group (NR group, n = 20). Proportion of white blood cell count (WBC) >/= 30 x 10(9)/L in the regression group (10.0% vs. 60.0%, p < 0.001), pericoronary CT fat attenuation index (-71.9 +/- 4.5 HU vs.-66.4 +/- 3.7 HU, p < 0.001), aneurysm maximum diameter (4.28 +/- 2.15 mm vs. 6.86 +/- 2.20 mm, p < 0.001), and Z-score (4.6 +/- 2.7 vs. 8.6 +/- 4.0, p < 0.001) were significantly lower than those in the non-regressive group. In addition, the distribution of coronary aneurysm size grades was significantly different between the two groups (p < 0.001), with medium (55.0%) and giant aneurysms (30.0%) predominating in the non-regression group and small aneurysms (80.0%) predominating in the regression group. Multivariate logistic regression analysis identified white blood cell (WBC) count >/= 30 x 10(9)/L (OR 0.02, 95% CI 0.00-0.47, p = 0.016), higher pericoronary computed tomography fat attenuation index (CT FAI) (OR 0.62, 95% CI 0.43-0.89, p = 0.009), and higher Z‑values (OR 0.76, 95% CI 0.58-1.00, p = 0.049) as adverse factors for coronary artery aneurysm (CAA) regression. Based on the Youden index derived from the receiver operating characteristic curve, the optimal cutoff values for predicting CAA regression were - 68.7 HU for the mean FAI and 4.6 for the Z‑score. In KD patients with CAAs, smaller initial aneurysm Z-score, the absence of extreme leukocytosis (WBC >/= 30 x 10(9)/L), and lower fat attenuation index (FAI) are associated with a higher likelihood of CAA regression. These findings suggest that both the initial morphological severity of the aneurysm and the state of pericoronary inflammation, as potentially reflected by FAI, are critical determinants of vascular remodeling outcomes. FAU - Li, Yong AU - Li Y AD - Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Bai, Zhiqiang AU - Bai Z AD - Department of Radiology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. FAU - Chen, Xuezhen AU - Chen X AD - Children's Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Yanjiang River Road, 107th, Yuexiu District, Guangzhou, 510000, China. chenxzh65@mail.sysu.edu.cn. LA - eng GR - 2025C009/Science and Technology Bureau of Shanwei City/ PT - Journal Article DEP - 20260404 PL - United States TA - Int J Cardiovasc Imaging JT - The international journal of cardiovascular imaging JID - 100969716 SB - IM PMC - PMC13433420 OTO - NOTNLM OT - Coronary artery aneurysms OT - Kawasaki disease OT - Pericoronary adipose tissue OT - Regression COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/04/04 00:36 MHDA- 2026/04/04 00:36 PMCR- 2026/04/04 CRDT- 2026/04/03 23:27 PHST- 2026/03/16 00:00 [received] PHST- 2026/03/31 00:00 [accepted] PHST- 2026/04/04 00:36 [pubmed] PHST- 2026/04/04 00:36 [medline] PHST- 2026/04/03 23:27 [entrez] PHST- 2026/04/04 00:00 [pmc-release] AID - 10.1007/s10554-026-03701-0 [pii] AID - 3701 [pii] AID - 10.1007/s10554-026-03701-0 [doi] PST - ppublish SO - Int J Cardiovasc Imaging. 2026 Aug;42(8):1545-1554. doi: 10.1007/s10554-026-03701-0. Epub 2026 Apr 4. PMID- 41932815 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 2052-4439 (Electronic) IS - 2052-4439 (Linking) VI - 13 IP - 1 DP - 2026 Apr 3 TI - Measurement of lung clearance index (LCI(2.5)) by nitrogen multiple breath washout (N(2)-MBW) is feasible and well‍-‍tolerated by adults and children with cystic fibrosis. LID - 10.1136/bmjresp-2025-003905 [doi] LID - e003905 AB - BACKGROUND: Lung clearance index (LCI(2.5)), measured by nitrogen-multiple breath washout (N(2)-MBW), is a sensitive measure of ventilatory inhomogeneity that can be performed awake/unsedated from aged 3 years. However, concerns have been raised about the feasibility of LCI(2.5) measurement by N(2)-MBW in adults with cystic fibrosis (CF), especially those with advanced lung disease, due to prolonged test durations. We assessed the feasibility, technical acceptability and patient perception of N(2)-MBW in adults and children/adolescents with CF within the exercise as an airway clearance technique-CF feasibility trial. METHODS: N(2)-MBW (Exhalyzer-D, EcoMedics, Switzerland) was performed on two separate occasions, by multidisciplinary trial staff. Data were centrally over-read (European Cystic Fibrosis Society LCI Core Facility). Outcomes included the proportion of technically acceptable tests, numbers of trials per test, times per trial and total time to perform N(2)-MBW. Comparisons were made according to age group and forced expiratory volume in 1 s (FEV(1)) category (>70% vs <70% predicted). Participants also completed a questionnaire assessing acceptability and willingness to repeat testing. RESULTS: 49 participants (21 female; age: 10-55 years, FEV(1): 38%-113% predicted) completed N(2)-MBW. Median (IQR) test durations were similar for adults (42 (27-55) min) and children (37 (26-44) min) with CF. Technically acceptable LCI(2.5) results were obtained for 90/94 (95.8%) tests. Most participants rated the test easy to perform (87%) and comfortable (93%), with none reporting unwillingness to repeat N(2)-MBW testing. CONCLUSIONS: N(2)-MBW testing is feasible, technically acceptable and well-tolerated in people with CF across a wide age and disease severity spectrum. With appropriate standardised training and over-reading, LCI(2.5) represents a robust outcome measure for consideration in CF clinical trials. TRIAL REGISTRATION NUMBER: NCT05482048. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Urquhart, Don S AU - Urquhart DS AUID- ORCID: 0000-0002-9048-9692 AD - Department of Child Life and Health, The University of Edinburgh, Edinburgh, UK don.urquhart@nhslothian.scot.nhs.uk. AD - Department of Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children and Young People, Edinburgh, UK. FAU - Taylor, Emily J AU - Taylor EJ AUID- ORCID: 0009-0004-9541-785X AD - Department of Child Life and Health, The University of Edinburgh, Edinburgh, UK. AD - Department of Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children and Young People, Edinburgh, UK. FAU - Miller, Debbie AU - Miller D AD - Adult Cystic Fibrosis Unit, Western General Hospital, Edinburgh, UK. FAU - Bowens, Donna AU - Bowens D AD - University Hospitals Southampton NHS Foundation Trust, Southampton, UK. FAU - Lacey, Ellen AU - Lacey E AD - University Hospitals Southampton NHS Foundation Trust, Southampton, UK. FAU - Abkir, Mary AU - Abkir M AD - National Heart and Lung Institute, Imperial College London, London, UK. AD - European Cystic Fibrosis Society, Lung Clearance Index Core Facility, London, UK. FAU - Saunders, Clare J AU - Saunders CJ AD - National Heart and Lung Institute, Imperial College London, London, UK. AD - European Cystic Fibrosis Society, Lung Clearance Index Core Facility, London, UK. FAU - Cunningham, Steve AU - Cunningham S AD - Department of Child Life and Health, The University of Edinburgh, Edinburgh, UK. AD - Centre for Inflammation Research, The University of Edinburgh, Edinburgh, UK. FAU - Saynor, Zoe Louise AU - Saynor ZL AUID- ORCID: 0000-0003-0674-8477 AD - University Hospitals Southampton NHS Foundation Trust, Southampton, UK. AD - School of Health Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK. CN - ExACT-CF study group LA - eng SI - ClinicalTrials.gov/NCT05482048 PT - Journal Article PT - Observational Study DEP - 20260403 PL - England TA - BMJ Open Respir Res JT - BMJ open respiratory research JID - 101638061 RN - N762921K75 (Nitrogen) SB - IM MH - Adolescent MH - Adult MH - Child MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Breath Tests/methods MH - *Cystic Fibrosis/physiopathology/diagnosis MH - Feasibility Studies MH - Forced Expiratory Volume MH - *Lung/physiopathology MH - *Nitrogen/analysis MH - *Respiratory Function Tests/methods MH - Randomized Controlled Trials as Topic PMC - PMC13052781 OTO - NOTNLM OT - Cystic Fibrosis OT - Lung Physiology OT - Respiratory Measurement COIS- Competing interests: None declared. FIR - Urquhart, Don S IR - Urquhart DS FIR - Taylor, Emily IR - Taylor E FIR - Miller, Debbie IR - Miller D FIR - Bowens, Donna IR - Bowens D FIR - Cunningham, Steve IR - Cunningham S FIR - Lewis, Steff IR - Lewis S FIR - Neilson, Aileen Rae IR - Neilson AR FIR - Soilemezi, Dia IR - Soilemezi D FIR - Ensor, Hannah IR - Ensor H FIR - Vogiatizis, Ioannis IR - Vogiatizis I FIR - Allen, Lorna IR - Allen L FIR - Kilarski, Ellyse IR - Kilarski E FIR - Lacey, Ellen IR - Lacey E FIR - Connett, Gary IR - Connett G FIR - Legg, Julian IR - Legg J FIR - Evans, Hazel IR - Evans H FIR - Daniels, Thom IR - Daniels T FIR - Allenby, Mark IR - Allenby M FIR - Carroll, Mary IR - Carroll M FIR - Gray, Robert IR - Gray R FIR - Echevarria, Carlos IR - Echevarria C FIR - Morrison, Lisa IR - Morrison L FIR - MacGregor, Gordon IR - MacGregor G FIR - Abkir, Mary IR - Abkir M FIR - Saunders, Clare IR - Saunders C FIR - Saynor, Zoe L IR - Saynor ZL EDAT- 2026/04/04 00:36 MHDA- 2026/04/04 00:37 PMCR- 2026/04/03 CRDT- 2026/04/03 21:02 PHST- 2025/10/27 00:00 [received] PHST- 2026/02/28 00:00 [accepted] PHST- 2026/04/04 00:37 [medline] PHST- 2026/04/04 00:36 [pubmed] PHST- 2026/04/03 21:02 [entrez] PHST- 2026/04/03 00:00 [pmc-release] AID - 13/1/e003905 [pii] AID - bmjresp-2025-003905 [pii] AID - 10.1136/bmjresp-2025-003905 [doi] PST - epublish SO - BMJ Open Respir Res. 2026 Apr 3;13(1):e003905. doi: 10.1136/bmjresp-2025-003905. PMID- 41931948 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260921 IS - 1873-5711 (Electronic) IS - 1050-6411 (Print) IS - 1050-6411 (Linking) VI - 88 DP - 2026 Jun TI - Reliability of bioimpedance spectroscopy in the upper trapezius muscle. PG - 103149 LID - S1050-6411(26)00045-3 [pii] LID - 10.1016/j.jelekin.2026.103149 [doi] AB - OBJECTIVE: Localized bioimpedance spectroscopy (BIS) is a non-invasive technique for assessing muscle tissue properties. This study examined the test-retest reliability of BIS measurements on the upper trapezius muscle and the effects of body positioning and electrode reapplication. APPROACH: Ten healthy adults (ages 18-30) with no history of neck or shoulder pain participated in the study. BIS measurements were collected over two days across three body positions (prone, seated, seated with neck bent) and with different electrode applications. Key impedance parameters were extracted from Cole-Cole plots. We evaluated measurement reliability, variability, and the minimum detectable change. MAIN RESULTS: BIS measures demonstrated high reliability for primary impedance parameters when body positioning was controlled, whereas model-derived parameters showed greater variability. Impedance parameters differed if the participants were seated or lying prone but were not sensitive to bending the neck to the side. Electrode reapplication did not significantly alter measures unless applied a third time, and sex-related differences were not significant. SIGNIFICANCE: BIS appears to be a reliable method for assessing upper trapezius muscle tissue properties when body position is standardized. Future research should explore BIS applications in larger and more diverse populations and evaluate its potential clinical utility. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Lamarre, Morgan A AU - Lamarre MA AD - Department of Bioengineering, George Mason University, Fairfax, VA, United States. FAU - Koduri, Sresta AU - Koduri S AD - Department of Bioengineering, George Mason University, Fairfax, VA, United States. FAU - Akhwand, Reihana A AU - Akhwand RA AD - Department of Bioengineering, George Mason University, Fairfax, VA, United States. FAU - Hsu, Yu-Lin AU - Hsu YL AD - Department of Statistics, George Mason University, Fairfax, VA, United States. FAU - Lee, Seiyon AU - Lee S AD - Department of Statistics, George Mason University, Fairfax, VA, United States; Center for MedTech Innovation, George Mason University, Fairfax, VA, United States. FAU - Rosenberger, William F AU - Rosenberger WF AD - Department of Statistics, George Mason University, Fairfax, VA, United States; Center for MedTech Innovation, George Mason University, Fairfax, VA, United States. FAU - DeStefano, Secili AU - DeStefano S AD - Optimal Motion Physical Therapy, Herndon, VA, United States; Center for MedTech Innovation, George Mason University, Fairfax, VA, United States. FAU - Srbely, John AU - Srbely J AD - Department of Human Health and Nutritional Sciences, University of Guelph, ON, Canada. FAU - Shah, Jay P AU - Shah JP AD - Rehabilitation Medicine Department, National Institutes of Health Clinical Center, Bethesda, MD, United States. FAU - Gerber, Lynn H AU - Gerber LH AD - Department of Medicine, INOVA Health System, Fairfax, VA, United States; Center for MedTech Innovation, George Mason University, Fairfax, VA, United States. FAU - Acuna, Samuel A AU - Acuna SA AD - Department of Bioengineering, George Mason University, Fairfax, VA, United States; Center for MedTech Innovation, George Mason University, Fairfax, VA, United States. Electronic address: sacuna2@gmu.edu. FAU - Sikdar, Siddhartha AU - Sikdar S AD - Department of Bioengineering, George Mason University, Fairfax, VA, United States; Center for MedTech Innovation, George Mason University, Fairfax, VA, United States. Electronic address: ssikdar@gmu.edu. LA - eng GR - R61 AT012286/AT/NCCIH NIH HHS/United States PT - Journal Article DEP - 20260328 PL - England TA - J Electromyogr Kinesiol JT - Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology JID - 9109125 SB - IM MH - Humans MH - Female MH - Male MH - Reproducibility of Results MH - *Superficial Back Muscles/physiology MH - Adult MH - Young Adult MH - Sensitivity and Specificity MH - *Dielectric Spectroscopy/methods MH - Adolescent MH - *Muscle Contraction/physiology MH - *Body Composition/physiology PMC - PMC13132660 MID - NIHMS2161100 OTO - NOTNLM OT - Electrical impedance myography OT - Electrode placement OT - Electrophysiology OT - Reliability OT - Tissue properties COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/04 00:35 MHDA- 2026/05/15 03:09 PMCR- 2026/05/01 CRDT- 2026/04/03 18:02 PHST- 2025/11/26 00:00 [received] PHST- 2026/03/24 00:00 [revised] PHST- 2026/03/27 00:00 [accepted] PHST- 2026/05/15 03:09 [medline] PHST- 2026/04/04 00:35 [pubmed] PHST- 2026/04/03 18:02 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - S1050-6411(26)00045-3 [pii] AID - 10.1016/j.jelekin.2026.103149 [doi] PST - ppublish SO - J Electromyogr Kinesiol. 2026 Jun;88:103149. doi: 10.1016/j.jelekin.2026.103149. Epub 2026 Mar 28. PMID- 41931044 OWN - NLM STAT- MEDLINE DCOM- 20261004 LR - 20261016 IS - 2831-090X (Electronic) IS - 2831-0896 (Print) IS - 2831-0896 (Linking) VI - 26 IP - 11 DP - 2026 Apr 2 TI - Prognostic nutritional index predicts 1-year hospitalization and mortality in outpatients with cirrhosis. PG - 2031-2040 LID - 10.17305/bb.2026.14035 [doi] AB - Malnutrition is prevalent in patients with cirrhosis and is linked to negative clinical outcomes. However, research on the prognostic nutritional index (PNI) and the burden of hospitalization over one year in stable outpatients remains limited. This study aimed to assess the relationship between PNI and liver-related hospitalization outcomes, as well as 12-month mortality, in outpatients with cirrhosis. In this retrospective single-center study, 125 adult patients with stable cirrhosis were analyzed, focusing on baseline demographic, clinical, laboratory, and 12-month follow-up data. Logistic regression was employed to evaluate the incidence of hospitalization in the entire cohort, while Poisson regression assessed hospital admission counts among patients with complete follow-up, and linear regression investigated the total length of stay for hospitalized patients.The results indicated that lower PNI values were significantly correlated with an increased likelihood of hospitalization and a higher frequency of hospital admissions within one year. In multivariable analysis, PNI remained an independent predictor of hospitalization (odds ratio [OR] = 0.655, 95% confidence interval [CI]: 0.530-0.809, p < 0.001) and admission frequency (incidence rate ratio [IRR] = 0.90, 95% CI: 0.848-0.955, p < 0.001), while no significant association was found with the length of hospital stay. Each 5-unit increase in PNI corresponded to substantially lower odds of hospitalization (OR = 0.121, 95% CI: 0.042-0.347) and a reduced admission rate (IRR = 0.59, 95% CI: 0.444-0.794). Additionally, PNI exhibited significant negative correlations with the Model for End-Stage Liver Disease-Sodium (MELD-Na) and Child-Turcotte-Pugh scores (all p < 0.001). PNI also demonstrated strong predictive validity for 12-month cirrhosis-related mortality, with an area under the curve (AUC) of 0.873 (95% CI: 0.802-0.943) and an optimal cut-off value of 38.5. Patients with a PNI /=14 days of parenteral nutrition as an additional predictor, to identify infants requiring treatment for retinopathy of prematurity (ROP) in a contemporary Swedish cohort, estimate potential cost savings and compare DIGIROP performance with other models. METHODS: Infants born in Sweden, 2021-2023 (n=1530) were evaluated. ROP and neonatal data were retrieved from Swedish quality registers. Sensitivity, specificity and the area under the receiver operating characteristic (AUC) curve were calculated. In the Vastra Gotaland Region cohort (n=245), the DIGIROP models were compared with WINROP and two Postnatal Growth and ROP (G-ROP) models. We estimated DIGIROP models' cost-saving. RESULTS: The mean gestational age was 27.7 (SD 2.2) weeks, birth weight 1029 (SD 317) g, 689 (45.0%) were girls and 85 (5.6%) infants received ROP treatment. For DIGIROP-Prescreen 2.0, the AUC was 0.89 (95% CI 0.86 to 0.92), sensitivity was 100% (95% CI 95.8% to 100%) and specificity 27.5% (95% CI 25.3% to 29.9%). For DIGIROP-Screen 2.0, the cumulative specificity increased from 27.7% to 67.8% between postnatal weeks 6-14, with a sensitivity of 100%. In total, approximately Int$750 000 could have been saved in screening costs in Sweden during 2021-2023 using DIGIROP models. DIGIROP-Screen at postnatal age 10 weeks had the same sensitivity but higher specificity than G-ROP. WINROP showed lower sensitivity but the highest specificity. CONCLUSION: DIGIROP 2.0 demonstrated high sensitivity and the most robust discrimination for treatment-requiring ROP in a contemporary Swedish cohort, compared with other models, with the potential to reduce unnecessary eye examinations and healthcare costs. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Pivodic, Aldina AU - Pivodic A AUID- ORCID: 0000-0002-2224-3236 AD - Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Department of Ophthalmology, Sahlgrenska University Hospital, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden. FAU - Karin, Berg AU - Karin B AD - Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Department of Ophthalmology, Sahlgrenska University Hospital, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden. FAU - Wallander, Jenny AU - Wallander J AD - Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Smith, Lois AU - Smith L AD - The Department of Ophthalmology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts, USA. FAU - Larsson, Eva AU - Larsson E AUID- ORCID: 0000-0001-9674-0094 AD - Department of Surgical Sciences, Ophthalmology, Uppsala University, Uppsala, Sweden. FAU - Tsamadou, Despina AU - Tsamadou D AD - Department of Ophthalmology, Orebro University Hospital, Orebro, Sweden. FAU - Sandgren Hochhard, Karin AU - Sandgren Hochhard K AD - Department of Clinical Sciences, Ophthalmology, Umea University, Umea, Sweden. FAU - Tear Fahnehjelm, Kristina AU - Tear Fahnehjelm K AD - Department of Clinical Neuroscience, Section for Eye and Vision, Karolinska Institute, Stockholm, Sweden. AD - Department of Pediatric Ophthalmology, St Erik Eye Hospital, Stockholm, Sweden. FAU - Granse, Lotta AU - Granse L AD - Department of Clinical Sciences, Ophthalmology, Skane University Hospital, Lund University, Lund, Sweden. FAU - Holmstrom, Gerd E AU - Holmstrom GE AUID- ORCID: 0000-0002-5600-7186 AD - Department of Surgical Sciences, Ophthalmology, Uppsala University, Uppsala, Sweden. FAU - Hellstrom, Ann AU - Hellstrom A AUID- ORCID: 0000-0002-9259-1244 AD - Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Department of Ophthalmology, Sahlgrenska University Hospital, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden. FAU - Lundgren, Pia AU - Lundgren P AUID- ORCID: 0000-0002-7731-1988 AD - Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden pia.lundgren@gu.se. AD - Department of Ophthalmology, Sahlgrenska University Hospital, Sahlgrenska University Hospital, Region Vastra Gotaland, Gothenburg, Sweden. LA - eng PT - Journal Article PT - Validation Study DEP - 20260402 PL - England TA - BMJ Open Ophthalmol JT - BMJ open ophthalmology JID - 101714806 SB - IM MH - Humans MH - Sweden/epidemiology MH - Female MH - *Retinopathy of Prematurity/diagnosis/therapy/epidemiology MH - Infant, Newborn MH - Male MH - *Parenteral Nutrition MH - Gestational Age MH - *Neonatal Screening/methods MH - Sensitivity and Specificity MH - ROC Curve PMC - PMC13052817 OTO - NOTNLM OT - Retina COIS- Competing interests: None declared. EDAT- 2026/04/03 00:31 MHDA- 2026/04/03 00:32 PMCR- 2026/04/02 CRDT- 2026/04/02 21:13 PHST- 2026/01/07 00:00 [received] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/04/03 00:32 [medline] PHST- 2026/04/03 00:31 [pubmed] PHST- 2026/04/02 21:13 [entrez] PHST- 2026/04/02 00:00 [pmc-release] AID - bmjophth-2026-002727 [pii] AID - 10.1136/bmjophth-2026-002727 [doi] PST - epublish SO - BMJ Open Ophthalmol. 2026 Apr 2;11(2):e002727. doi: 10.1136/bmjophth-2026-002727. PMID- 41927221 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260818 IS - 1532-9283 (Electronic) IS - 1360-8592 (Linking) VI - 46 DP - 2026 Jun TI - Functional and structural effects of local vs. global motor control training: An ultrasound-based study on deep abdominal muscles. PG - 555-563 LID - S1360-8592(25)00515-7 [pii] LID - 10.1016/j.jbmt.2025.12.028 [doi] AB - BACKGROUND: Trunk stabilization is essential in rehabilitation and sports training, relying on anticipatory activation of deep trunk muscles like the transverse abdominis. OBJECTIVES: This study assessed the effects of 4-week motor control training programs (global and local) on lateral abdominal wall muscle thickness and functional parameters. METHODS: Fifty-eight participants were enrolled, and forty-eight (35 women, 13 men) completed the study. Inclusion criteria were: age 18-40 years, BMI 0.05). Ultrasound transducer positioning (parallel vs. perpendicular) affected measurement reliability for oblique muscles. CONCLUSIONS: Global training led to hypertrophic changes in lateral abdominal muscles. Local training showed a trend toward increased transverse abdominis thick-ness but without statistical significance. Ultrasound measurements may be less reliable when the transducer is positioned parallel to the body midline. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Szuscik-Niewiadomy, Katarzyna AU - Szuscik-Niewiadomy K AD - Department of Adapted Physical Activity and Sport, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Katowice, Poland. Electronic address: kszuscik@sum.edu.pl. FAU - Niewiadomy, Pawel AU - Niewiadomy P AD - Department of Balneoclimatology and Biological Regeneration, School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Katowice, Poland. Electronic address: pniewiadomy@sum.edu.pl. FAU - Stana, Oskar AU - Stana O AD - School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Katowice, Poland. Electronic address: oskar.stana@hotmail.com. FAU - Nowak, Michal AU - Nowak M AD - School of Health Sciences in Katowice, Medical University of Silesia in Katowice, Katowice, Poland. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20251216 PL - United States TA - J Bodyw Mov Ther JT - Journal of bodywork and movement therapies JID - 9700068 SB - IM MH - Humans MH - Female MH - *Abdominal Muscles/diagnostic imaging/physiology/anatomy & histology MH - Male MH - Ultrasonography MH - Adult MH - Young Adult MH - Adolescent MH - *Exercise Therapy/methods MH - Biofeedback, Psychology OTO - NOTNLM OT - Core stabilization OT - Lateral abdominal wall muscles OT - Motor control training OT - Pressure biofeedback stabilizer OT - Transverse abdominis OT - Ultrasound COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/03 00:31 MHDA- 2026/04/03 00:32 CRDT- 2026/04/02 20:54 PHST- 2025/07/16 00:00 [received] PHST- 2025/12/10 00:00 [revised] PHST- 2025/12/12 00:00 [accepted] PHST- 2026/04/03 00:32 [medline] PHST- 2026/04/03 00:31 [pubmed] PHST- 2026/04/02 20:54 [entrez] AID - S1360-8592(25)00515-7 [pii] AID - 10.1016/j.jbmt.2025.12.028 [doi] PST - ppublish SO - J Bodyw Mov Ther. 2026 Jun;46:555-563. doi: 10.1016/j.jbmt.2025.12.028. Epub 2025 Dec 16. PMID- 41927200 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260715 IS - 1532-9283 (Electronic) IS - 1360-8592 (Linking) VI - 46 DP - 2026 Jun TI - The relationship between video game addiction, neck disability and upper extremity functional limitations in adolescents' students. PG - 404-412 LID - S1360-8592(25)00500-5 [pii] LID - 10.1016/j.jbmt.2025.12.013 [doi] AB - BACKGROUND: Video gaming is a popular leisure activity among adolescents who are in danger of musculoskeletal disorders. So, the current study evaluated the video game addiction (GA) risk factors and investigated its relationship with neck disability and upper limb functional limitations among adolescents. METHODS: A cross-sectional study of 414 adolescents was conducted via a survey in Taif city, Saudi Arabia. The validated Arabic versions of the GA scale, neck disability index and upper limb functional limitations index were used to detect GA, evaluate neck disability and assess functional dysfunctions of upper extremities, respectively. The descriptive statistics and Chi-square test were used to analyze data. Logistic regression analysis was performed to identify the predictors of video GA. RESULTS: The prevalence of addicted gamers was 14.50 % (males: 13.54 %, and females: 15.32 %). The middle and secondary schools addicted students' prevalence was 23.85 % and 11.15 % respectively. Students in middle schools were more likely to be addicted gamers 2.29 times more than secondary school students (p = 0.014). Of the addicted gamers, 53.33 % had neck disabilities and 15.00 % had upper limb functional limitations. Neck disability and upper limb functional limitations were not associated with GA (p = 0.654, 0.475 respectively). CONCLUSION: The prevalence of GA was 14.50 % among adolescents. The middle schools are more predictive to GA than secondary schools. GA was not a predictor for neck disability or upper limb dysfunctions. To prevent GA, early diagnosis, controlling the accessibility of video games and promoting physical activity are essential to limit its disorders and related risks. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Abdel-Aziem, Amr Almaz AU - Abdel-Aziem AA AD - Department of Physical Therapy, College Applied Medical Sciences, Taif University, Saudi Arabia; Department of Biomechanics, Faculty of Physical Therapy, Cairo University, Egypt. Electronic address: amralmaz@yahoo.com. FAU - Alharthi, Ahad Zid AU - Alharthi AZ AD - Department of Physical Therapy, College Applied Medical Sciences, Taif University, Saudi Arabia. Electronic address: ahadzaid262@gmail.com. FAU - AlOtaibi, Manar Abdullah AU - AlOtaibi MA AD - Department of Physical Therapy, College Applied Medical Sciences, Taif University, Saudi Arabia. Electronic address: alotibimanar88@gmail.com. FAU - Althaqafi, Miad Mutlaq AU - Althaqafi MM AD - Department of Physical Therapy, College Applied Medical Sciences, Taif University, Saudi Arabia. Electronic address: meadalthaqafi@gmail.com. FAU - AlOsaimi, Norah Ali AU - AlOsaimi NA AD - Department of Physical Therapy, College Applied Medical Sciences, Taif University, Saudi Arabia. Electronic address: alosaiminoora2@gmail.com. FAU - Altowirqi, Taef Wail AU - Altowirqi TW AD - Department of Physical Therapy, College Applied Medical Sciences, Taif University, Saudi Arabia. Electronic address: taef14455@gmail.com. FAU - Aldina, Wasan Mahmoud AU - Aldina WM AD - Department of Physical Therapy, College Applied Medical Sciences, Taif University, Saudi Arabia. Electronic address: waldenar26@gmail.com. LA - eng PT - Journal Article DEP - 20251205 PL - United States TA - J Bodyw Mov Ther JT - Journal of bodywork and movement therapies JID - 9700068 SB - IM MH - Humans MH - *Video Games/adverse effects MH - Adolescent MH - Female MH - *Upper Extremity/physiopathology MH - Cross-Sectional Studies MH - Saudi Arabia/epidemiology MH - Male MH - *Behavior, Addictive/epidemiology MH - Risk Factors MH - *Neck Pain/epidemiology MH - Disability Evaluation MH - Prevalence MH - Students OTO - NOTNLM OT - Functional disability OT - Gaming addiction OT - Neck pain OT - School adolescents OT - Upper limb COIS- Declaration of competing interest There is no conflict of interest to be declared. EDAT- 2026/04/03 00:31 MHDA- 2026/04/03 00:32 CRDT- 2026/04/02 20:54 PHST- 2024/12/21 00:00 [received] PHST- 2025/11/29 00:00 [revised] PHST- 2025/12/03 00:00 [accepted] PHST- 2026/04/03 00:32 [medline] PHST- 2026/04/03 00:31 [pubmed] PHST- 2026/04/02 20:54 [entrez] AID - S1360-8592(25)00500-5 [pii] AID - 10.1016/j.jbmt.2025.12.013 [doi] PST - ppublish SO - J Bodyw Mov Ther. 2026 Jun;46:404-412. doi: 10.1016/j.jbmt.2025.12.013. Epub 2025 Dec 5. PMID- 41926828 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 2213-1582 (Electronic) IS - 2213-1582 (Linking) VI - 50 DP - 2026 TI - Grey matter volume associations with personality functioning in a clinical cohort of female youths. PG - 103988 LID - S2213-1582(26)00047-1 [pii] LID - 10.1016/j.nicl.2026.103988 [doi] LID - 103988 AB - Borderline Personality Disorder (BPD) is a severe mental illness, although its neurobiological underpinnings remain largely unknown. Structural Magnetic Resonance Imaging (sMRI) in adolescents can offer insights into potential biomarkers to help advance early detection and targeted intervention. However, previous findings have been mixed, possibly due to clinical heterogeneity that may be better captured using a dimensional approach to personality functioning (PF). The current study explored grey matter volume (GMV) in youth with varying degrees of BPD pathology, and associations with dimensional PF. N = 93 females (14-21 years) comprising three groups (full-threshold BPD, sub-threshold BPD, and healthy controls) underwent sMRI and were assessed with the Semi-Structured Interview for Personality Functioning DSM-5 (STiP-5.1). Groups were combined to reflect dimensional personality pathology. Multiple linear regression analyses were conducted to determine associations between the STiP-5.1 total score, and each of its four elements with: (i) total GMV, (ii) GMV in individual brain regions defined by the Desikan-Killiany-Tourville atlas, (iii) selected regions of interest (ROIs). All analyses were statistically non-significant: STiP-5.1 total and total GMV (p = 0.61); STiP-5.1 total and individual brain regions (all corrected p values >/=0.82); STiP-5.1 total and ROIs (all corrected p values >/=0.91). Results were non-significant for each element, and a validity check using BPD criteria confirmed STiP-5.1 findings. We found no evidence of an association of dimensionally assessed PF with GMV in young females. The pursuit of clinical research efforts on other potential biomarkers using dimensional conceptualisations of PF may represent worthy endeavours. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Thomson, Madelyn AU - Thomson M AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Graduate School for Health Sciences, University of Bern, Switzerland. FAU - Cavelti, Marialuisa AU - Cavelti M AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland. FAU - Murner-Lavanchy, Ines AU - Murner-Lavanchy I AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Faculty of Psychology, University of Basel, Switzerland. FAU - Sele, Silvano AU - Sele S AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland. FAU - Burgi, Niklas AU - Burgi N AD - Department of Economics, University of Zurich, Switzerland; Max Planck Institute for Biological Cybernetics, Tubingen, Germany. FAU - Seiffert, Nora AU - Seiffert N AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland. FAU - Moggi, Franz AU - Moggi F AD - Translational Research Center, University Hospital for Psychiatry and Psychotherapy, University of Bern, Switzerland. FAU - Wiest, Roland AU - Wiest R AD - University Institute of Diagnostic and Interventional Neuroradiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Translational Imaging Center (TIC), Swiss Institute for Translational and Entrepreneurial Medicine, Bern, Switzerland. FAU - Koenig, Julian AU - Koenig J AD - University of Cologne, Faculty of Medicine and University Hospital Cologne, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Cologne, Germany. FAU - Kaess, Michael AU - Kaess M AD - University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland; Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany. Electronic address: michael.kaess@upd.ch. LA - eng PT - Journal Article DEP - 20260328 PL - Netherlands TA - Neuroimage Clin JT - NeuroImage. Clinical JID - 101597070 SB - IM MH - Humans MH - Female MH - Adolescent MH - Magnetic Resonance Imaging MH - *Gray Matter/diagnostic imaging/pathology MH - *Borderline Personality Disorder/diagnostic imaging/pathology MH - Young Adult MH - *Brain/diagnostic imaging/pathology MH - Cohort Studies MH - *Personality/physiology MH - Organ Size PMC - PMC13068870 OTO - NOTNLM OT - AMPD OT - Adolescents OT - Criterion A OT - Dimensional OT - Neuroimaging OT - Personality disorder COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/04/03 00:31 MHDA- 2026/06/13 06:38 PMCR- 2026/03/28 CRDT- 2026/04/02 18:06 PHST- 2025/03/20 00:00 [received] PHST- 2026/03/25 00:00 [revised] PHST- 2026/03/26 00:00 [accepted] PHST- 2026/06/13 06:38 [medline] PHST- 2026/04/03 00:31 [pubmed] PHST- 2026/04/02 18:06 [entrez] PHST- 2026/03/28 00:00 [pmc-release] AID - S2213-1582(26)00047-1 [pii] AID - 103988 [pii] AID - 10.1016/j.nicl.2026.103988 [doi] PST - ppublish SO - Neuroimage Clin. 2026;50:103988. doi: 10.1016/j.nicl.2026.103988. Epub 2026 Mar 28. PMID- 41925781 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Apr 2 TI - Cross-cultural adaptation and psychometric validation of the Turkish Dusseldorf Orthorexia Scale in adolescents. LID - 10.1007/s40519-026-01847-3 [doi] LID - 27 AB - PURPOSE: Orthorexia nervosa (ON) is characterized by an excessive preoccupation with healthy eating that may lead to rigidity, distress, and functional impairment. Validated instruments for assessing orthorexic tendencies in adolescent psychiatric settings remain limited. This study aimed to examine the psychometric properties of the Turkish version of the Dusseldorf Orthorexia Scale (TR-DOS) in a clinically referred adolescent sample. METHODS: Adolescents aged 12-18 years presenting to a child and adolescent psychiatry outpatient clinic completed the TR-DOS, Orthorexia Nervosa Inventory (ONI), Eating Attitudes Test-26 (EAT-26), and Revised Child Anxiety and Depression Scale-Child Version (RCADS-CV). Psychiatric diagnoses were established through clinician-administered DSM-5 interviews. Construct validity was examined using exploratory and confirmatory factor analyses, internal consistency using Cronbach's alpha and McDonald's omega, and convergent validity through correlations with related measures. RESULTS: The sample comprised 209 adolescents (61.2% female; mean age = 15.7 +/- 1.72 years). Exploratory factor analysis supported a single-factor solution. Confirmatory factor ana;lysis also supported a one-factor structure, with good model fit (chi(2)/df = 1.51, CFI = 0.977, TLI = 0.967, RMSEA = 0.049, SRMR = 0.039). All factor loadings were statistically significant, with standardized loadings ranging from 0.335 to 0.725. Internal consistency was high (Cronbach's alpha = 0.868; McDonald's omega = 0.871). TR-DOS scores were positively correlated with ONI and EAT-26, but not with BMI or RCADS-CV total anxiety. Adolescents with obsessive-compulsive disorder had significantly higher TR-DOS scores than those without this diagnosis. CONCLUSION: The TR-DOS demonstrated satisfactory validity and reliability in a clinically referred Turkish adolescent sample. Level of evidence Level V, descriptive study. CI - (c) 2026. The Author(s). FAU - Guney, Omca AU - Guney O AD - Department of Child and Adolescent Psychiatry, University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Istanbul, 34480, Turkey. FAU - Yildirim, Selman AU - Yildirim S AD - Department of Clinical Science, Umea University, 901 87, Umea, Sweden. selman.yildirim@umu.se. FAU - Akbas, Ibrahim Halil AU - Akbas IH AD - Department of Psychiatry, Sanliurfa Training and Research Hospital, Sanliurfa, 63250, Turkey. akbasibrahim1@gmail.com. FAU - Kinay Ermis, Duygu AU - Kinay Ermis D AD - Department of Child and Adolescent Psychiatry, University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Istanbul, 34480, Turkey. FAU - Kasar, Nurdan AU - Kasar N AD - Department of Child and Adolescent Psychiatry, University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Istanbul, 34480, Turkey. LA - eng PT - Journal Article PT - Validation Study DEP - 20260402 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - Adolescent MH - Female MH - Psychometrics MH - Turkey MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Male MH - Reproducibility of Results MH - Child MH - *Feeding Behavior/psychology MH - Cross-Cultural Comparison MH - Surveys and Questionnaires MH - Factor Analysis, Statistical MH - Psychiatric Status Rating Scales PMC - PMC13065574 OTO - NOTNLM OT - Adolescent mental health OT - Dusseldorf Orthorexia Scale OT - Eating behavior disorders OT - Orthorexia nervosa OT - Psychometric validation COIS- Declarations. Ethics approval and consent to participate: All procedures were carried out in accordance with the World Medical Association Declaration of Helsinki. Written and verbal consent was obtained from all participants following the provision of written information regarding the purpose and methodology of the study to participants who volunteered to participate. Competing interests: The authors declare no competing interests. EDAT- 2026/04/02 12:35 MHDA- 2026/04/09 12:45 PMCR- 2026/04/02 CRDT- 2026/04/02 11:05 PHST- 2025/11/18 00:00 [received] PHST- 2026/03/18 00:00 [accepted] PHST- 2026/04/09 12:45 [medline] PHST- 2026/04/02 12:35 [pubmed] PHST- 2026/04/02 11:05 [entrez] PHST- 2026/04/02 00:00 [pmc-release] AID - 10.1007/s40519-026-01847-3 [pii] AID - 1847 [pii] AID - 10.1007/s40519-026-01847-3 [doi] PST - epublish SO - Eat Weight Disord. 2026 Apr 2;31(1):27. doi: 10.1007/s40519-026-01847-3. PMID- 41925449 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260912 IS - 1873-5010 (Electronic) IS - 1569-1993 (Linking) VI - 25 IP - 4 DP - 2026 Jul TI - Effects of Elexacaftor/Tezacaftor/Ivacaftor on cough frequency, physical activity patterns, and sleep quality in adolescents and adults with cystic fibrosis. PG - 682-688 LID - S1569-1993(26)00083-4 [pii] LID - 10.1016/j.jcf.2026.03.016 [doi] AB - BACKGROUND: Cystic fibrosis (CF) transmembrane conductance regulator modulators improve lung function, however, effects on cough frequency, physical activity, and sleep have not been assessed in clinical studies. METHODS: After a 12-week, phase 4 pilot feasibility study, we conducted a 13-week, phase 3b, open-label study in participants with CF aged >/=12 years previously naive to elexacaftor/tezacaftor/ivacaftor (ELX/TEZ/IVA) to assess the effects of ELX/TEZ/IVA on cough frequency, physical activity, and sleep using wearable cough monitors and actigraphy sensors (VX-445-126). RESULTS: In study VX-445-126 (N = 81), participants treated with ELX/TEZ/IVA experienced a 91.7% reduction in cough frequency (cough events per day) (95% CI, 89.2% to 93.6%; 241.3 coughs per day at baseline to 20.3 coughs per day) from baseline at the average of week 8 through week 12 (primary endpoint). Total steps per day (secondary endpoint) increased by 638 (95% CI, 298 to 977) at the average of week 8 through week 12. Time spent above sedentary physical activity per day, time spent on moderate-to-vigorous physical activity per day, and total mean activity count per day all increased from baseline at the average of week 8 through week 12 (other efficacy endpoints). While no changes in sleep activity patterns were observed in actigraphy data, patient-reported measures of sleep quality improved (other efficacy endpoints). ELX/TEZ/IVA was generally safe and well-tolerated. CONCLUSIONS: ELX/TEZ/IVA treatment led to a > 90% reduction in daily cough frequency, with sustained improvements in physical activity and better perceptions of sleep quality. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Van Braeckel, Eva AU - Van Braeckel E AD - Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium; Department of Internal Medicine and Paediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium. Electronic address: Eva.VanBraeckel@UGent.be. FAU - Braun, Andrew T AU - Braun AT AD - University of Wisconsin School of Medicine and Public Health, Madison, WI, USA. FAU - Simmonds, Nicholas J AU - Simmonds NJ AD - National Heart and Lung Institute, Imperial College London UK, Royal Brompton Hospital, part of Guy's and St Thomas' NHS Foundation Trust, London, UK. FAU - Barry, Peter J AU - Barry PJ AD - Manchester University NHS Foundation Trust, Manchester, UK; Division of Infection, Immunity and Respiratory Medicine, University of Manchester, Manchester, UK. FAU - Davies, Jane C AU - Davies JC AD - National Heart and Lung Institute, Imperial College London UK, Royal Brompton Hospital, part of Guy's and St Thomas' NHS Foundation Trust, London, UK. FAU - Egan, Marie E AU - Egan ME AD - Yale University, New Haven, CT, USA. FAU - Lapey, Allen AU - Lapey A AD - Massachusetts General Hospital, Boston, MA, USA. FAU - Mall, Marcus A AU - Mall MA AD - Department of Pediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charite - Universitatsmedizin Berlin, Berlin, Germany; German Center for Lung Research (DZL), associated partner site, Berlin, Germany; German Center for Child and Adolescent Health (DZKJ), partner site Berlin, Berlin, Germany; Cluster of Excellence ImmunoPreCept, Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - McKone, Edward F AU - McKone EF AD - St Vincent's University Hospital, Dublin, Ireland. FAU - Peckham, Daniel AU - Peckham D AD - St James's University Hospital, Leeds, UK. FAU - Proesmans, Marijke AU - Proesmans M AD - University Hospital of Leuven, Leuven, Belgium. FAU - Ramsey, Bonnie AU - Ramsey B AD - Seattle Children's Hospital, Seattle, WA, USA. FAU - Santamaria, Saioa Vicente AU - Santamaria SV AD - Hospital Ramon y Cajal, Madrid, Spain. FAU - Smith, Daniel AU - Smith D AD - The Prince Charles Hospital, Brisbane, Queensland, Australia. FAU - Taylor-Cousar, Jennifer L AU - Taylor-Cousar JL AD - National Jewish Health, Denver, CO, USA. FAU - Tullis, Elizabeth AU - Tullis E AD - St Michael's Hospital, Toronto, Ontario, Canada. FAU - De Wachter, Elke AU - De Wachter E AD - Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium. FAU - Withers, Nick AU - Withers N AD - Royal Devon United Hospital NHS Foundation Trust, Exeter, UK. FAU - Ahluwalia, Neil AU - Ahluwalia N AD - Vertex Pharmaceuticals Incorporated, Boston, MA, USA. FAU - Conner, Sarah AU - Conner S AD - Vertex Pharmaceuticals Incorporated, Boston, MA, USA. FAU - Jennings, Mark AU - Jennings M AD - Vertex Pharmaceuticals Incorporated, Boston, MA, USA. FAU - Lou, Yiyue AU - Lou Y AD - Vertex Pharmaceuticals Incorporated, Boston, MA, USA. FAU - Weinstock, Tanya G AU - Weinstock TG AD - Vertex Pharmaceuticals Incorporated, Boston, MA, USA. FAU - Keating, Dominic AU - Keating D AD - Alfred Health, and Monash University, Melbourne, Victoria, Australia. LA - eng PT - Clinical Trial, Phase III PT - Clinical Trial, Phase IV PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260331 PL - Netherlands TA - J Cyst Fibros JT - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society JID - 101128966 RN - 0 (Aminophenols) RN - 0 (Benzodioxoles) RN - 0 (Chloride Channel Agonists) RN - 0 (Drug Combinations) RN - 0 (Indoles) RN - 0 (Pyrazoles) RN - 0 (Pyridines) RN - 0 (Pyrrolidines) RN - 0 (Quinolones) RN - 0 (tezacaftor, ivacaftor drug combination) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - Actigraphy/methods MH - Aminophenols/therapeutic use/administration & dosage MH - Benzodioxoles/therapeutic use/administration & dosage MH - *Chloride Channel Agonists/administration & dosage/therapeutic use MH - *Cough/drug therapy/etiology MH - *Cystic Fibrosis/drug therapy/complications/physiopathology MH - Drug Combinations MH - *Exercise MH - Feasibility Studies MH - Indoles/therapeutic use/administration & dosage MH - Pilot Projects MH - Pyrazoles/therapeutic use/administration & dosage MH - Pyridines/therapeutic use/administration & dosage MH - Pyrrolidines/therapeutic use MH - Quinolones/therapeutic use/administration & dosage MH - *Sleep Quality OTO - NOTNLM OT - Cough OT - Cystic fibrosis OT - Elexacaftor/tezacaftor/ivacaftor OT - Physical activity OT - Wearable technologies COIS- Declaration of competing interest EVB received fees for clinical trial leadership and participation, lectures and consultancy from Vertex Pharmaceuticals, all paid to her institution, and institutional fees for the conduct of CF clinical trials from AbbVie, Boehringer Ingelheim, and Galapagos. AB received grants from Vertex Pharmaceuticals and the Cystic Fibrosis Foundation. PJB reports speaker and consultancy fees from Vertex Pharmaceuticals. Member of DMC for Boehringer Ingelheim. EDW received institutional fees for study participation in clinical trials from Vertex Pharmaceuticals, Corbus and Ablynx. Her institution received honoraria for speaking and education activities and consultant work and for participation from Vertex Pharmaceuticals. She received support for attending travel and housing at CF-conferences by Viatris. MP received institutional fees for study participation in clinical trials from Vertex Pharmaceuticals. Her institution received honoraria for speaking and education activities and for participation in advisory boards from Vertex Pharmaceuticals. JCD has received fees from Vertex Pharmaceuticals to her university and hospital for clinical trial leadership/participation; has participated in Advisory Boards and educational/ speaking activities for Vertex Pharmaceuticals. JCD and NJS are supported by the National Institute of Health and Care Research (NIHR) through the Imperial Biomedical Research Centre, the Brompton Clinical Research Facility. JCD also has a Senior Investigator Award. NJS has participated in Advisory Boards and/or educational/speaking activities for Vertex Pharmaceuticals, Chiesi, Gilead, Teva and Boehringer Ingelheim. DP has participated in Advisory Boards and educational/speaking activities with Vertex Pharmaceuticals. JTC has received consulting fees/or has been on advisory board for Kither Biotech; has served as a DMC chair for AbbVie, received grant funding from the CF Foundation and NIH and has been an investigator on studies for 4DMT, Vertex Pharmaceuticals, Sionna, Splisense, BI, and Recode. Her institution has received funds for her advisory work from Vertex Pharmaceuticals and 4DMT. MP received institutional fees for study participation in clinical trials from Vertex Pharmaceuticals. Her institution received honoraria for participation in advisory boards from Vertex Pharmaceuticals. ET has received consulting and speaking fees from Vertex Pharmaceuticals Inc. NW has received fees from Vertex for Advisory Boards and educational/speaking activities. NA, SC, MJ, YL, and TGW are employees of Vertex Pharmaceuticals Incorporated. EM has participated in advisory boards for Vertex Pharmaceuticals and Enterprise Therapeutics, received grant funding from CF Foundation and Vertex Pharmaceuticals, and institutional fees for study participation in Vertex Pharmaceuticals clinical trials. MAM reports grants or contracts from Boehringer Ingelheim, Enterprise Therapeutics, Vertex Pharmaceuticals, German Federal Ministry of Research, Technology and Space (BMFTR) and German Research Foundation (DFG), with payments made to the institution; consulting fees from Boehringer Ingelheim, Enterprise Therapeutics, Kither Biotech, Splisense and Vertex Pharmaceuticals; payment or honoraria for lectures from Vertex Pharmaceuticals; travel reimbursement received for participation in advisory board meetings for Boehringer Ingelheim and Vertex Pharmaceuticals; and fees for participation on an advisory board from Boehringer Ingelheim, Enterprise Therapeutics, Kither Biotech, Pari and Vertex Pharmaceuticals. He is also an unpaid Fellow of ERS. EDAT- 2026/04/02 12:35 MHDA- 2026/07/31 00:38 CRDT- 2026/04/02 09:18 PHST- 2025/12/05 00:00 [received] PHST- 2026/03/05 00:00 [revised] PHST- 2026/03/20 00:00 [accepted] PHST- 2026/07/31 00:38 [medline] PHST- 2026/04/02 12:35 [pubmed] PHST- 2026/04/02 09:18 [entrez] AID - S1569-1993(26)00083-4 [pii] AID - 10.1016/j.jcf.2026.03.016 [doi] PST - ppublish SO - J Cyst Fibros. 2026 Jul;25(4):682-688. doi: 10.1016/j.jcf.2026.03.016. Epub 2026 Mar 31. PMID- 41924702 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260522 LR - 20260922 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Key predictors of postpartum depression and anxiety symptoms among mothers in Kilifi, Kenya: a machine learning approach. PG - 1790893 LID - 10.3389/fpsyt.2026.1790893 [doi] LID - 1790893 AB - BACKGROUND: The burden of maternal postpartum depression and anxiety is disproportionately high in sub-Saharan Africa (SSA), yet the use of advanced analytical methods to capture the complex interplay of variables influencing these conditions remains underexplored. OBJECTIVE: To apply machine learning (ML) methods to predict depressive and anxiety symptoms in postpartum mothers and to identify key and actionable predictors. METHODS: This cross-sectional study included 1,995 biological mothers of singleton infants aged 0-6 months, using survey data collected between March 2023 and March 2024 in Kaloleni and Rabai sub-counties, Kilifi County, Kenya, within the Kaloleni-Rabai Health and Demographic Surveillance System. Depressive and anxiety symptoms were assessed using the Patient Health Questionnaire-9 and Generalized Anxiety Disorder-7, with scores >/=5 indicating symptoms. Potential features included sociodemographic, economic, nutritional, food insecurity, and health-related factors. Ridge Logistic Regression (LR), Random Forest (RF), and Extreme Gradient Boosting (XGBoost) models were applied to predict depressive and anxiety symptoms. Model performance was evaluated using area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, and specificity. Shapley additive explanations values were used for feature selection and interpretation. RESULTS: Among the 1,995 mothers, 15.1% had depressive symptoms, and 8.7% had anxiety symptoms. Model performance was acceptable and comparable across all models. For depression, AUC values for Ridge LR, RF and XGBoost were 0.724 (95% CI: 0.656-0.785), 0.711 (95% CI: 0.642-0.774), and 0.705 (95% CI: 0.628-0.772) respectively. For anxiety, AUCs were 0.788 (95% CI: 0.712-0.857), 0.789 (95% CI: 0.709-0.861), and 0.785 (95% CI: 0.708-0.854), respectively. Increased household food insecurity was the strongest predictor of both conditions. Additional key predictors included low wealth index, lower body mass index, higher number of children, pregnancy complications and advanced maternal age. CONCLUSIONS: Postpartum mental health disorders remain a substantial burden in SSA. This study demonstrates the feasibility of using ML to predict depressive and anxiety symptoms in postpartum mothers. The findings identify key predictors, notably increased household food insecurity, alongside socioeconomic status and maternal health characteristics, that could inform the design and testing of targeted interventions. Future studies should include external validation and examine causal links between these predictors and postpartum mental health outcomes. CI - Copyright (c) 2026 Benson, Odhiambo, Brink, Ngugi, Waljee, Weinheimer-Haus, Moyer, Zhu and Abubakar. FAU - Benson, Faith Neema AU - Benson FN AD - Institute for Human Development, Aga Khan University, Nairobi, Kenya. AD - Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa. FAU - Odhiambo, Rachel AU - Odhiambo R AD - Institute for Human Development, Aga Khan University, Nairobi, Kenya. FAU - Brink, Willie AU - Brink W AD - Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa. FAU - Ngugi, Anthony K AU - Ngugi AK AD - Department of Population Health, Medical College, Aga Khan University, Nairobi, Kenya. FAU - Waljee, Akbar K AU - Waljee AK AD - Department of Learning Health Sciences, University of Michigan, Ann Arbor, MI, United States. AD - Center for Global Health Equity, University of Michigan, Ann Arbor, MI, United States. FAU - Weinheimer-Haus, Eileen M AU - Weinheimer-Haus EM AD - Department of Learning Health Sciences, University of Michigan, Ann Arbor, MI, United States. AD - Center for Global Health Equity, University of Michigan, Ann Arbor, MI, United States. FAU - Moyer, Cheryl A AU - Moyer CA AD - Department of Learning Health Sciences, University of Michigan, Ann Arbor, MI, United States. AD - Center for Global Health Equity, University of Michigan, Ann Arbor, MI, United States. FAU - Zhu, Ji AU - Zhu J AD - Department of Statistics, University of Michigan, Ann Arbor, MI, United States. FAU - Abubakar, Amina AU - Abubakar A AD - Institute for Human Development, Aga Khan University, Nairobi, Kenya. AD - Department of Psychiatry, University of Oxford, Oxford, United Kingdom. AD - Neuroscience Unit, Kenya Medical Research Institute (KEMRI)-Wellcome Trust Research Programme, Kilifi, Kenya. LA - eng GR - U54 TW012089/TW/FIC NIH HHS/United States PT - Journal Article DEP - 20260317 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC13036147 OTO - NOTNLM OT - machine learning OT - maternal mental health OT - postpartum anxiety OT - postpartum depression OT - predictive modeling COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/02 06:30 MHDA- 2026/04/02 06:31 PMCR- 2026/03/17 CRDT- 2026/04/02 04:46 PHST- 2026/01/19 00:00 [received] PHST- 2026/02/20 00:00 [revised] PHST- 2026/02/23 00:00 [accepted] PHST- 2026/04/02 06:30 [pubmed] PHST- 2026/04/02 06:31 [medline] PHST- 2026/04/02 04:46 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1790893 [doi] PST - epublish SO - Front Psychiatry. 2026 Mar 17;17:1790893. doi: 10.3389/fpsyt.2026.1790893. eCollection 2026. PMID- 41924069 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260402 LR - 20260927 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Methodological strategies for linking superordinate life goals (values) and daily activities: a cross-sectional online study of adolescents. PG - 1685340 LID - 10.3389/fpsyg.2026.1685340 [doi] LID - 1685340 AB - Adolescents pursue life goals through daily activities that pave the way toward a future or ideal self. Very little is known, however, regarding what youth consider to be important activities in support of their life goals. In the present study, we examined four psychometric methods of weighting and rank ordering activities associated with six life goals (Fitness, Helpful, Smart, Talented, Creative, and Social). Cross-sectional data were obtained from an online survey of 2,001 youth ages 13 to 15 who picked a life goal and then rated whether 21 activities align with their life goal. Eleven of the activities for each goal were selected by ChatGPT and mixed with 10 filler activities (drawn from the remaining life goals). Four weighting methods including an ipsative distribution-based approach, confirmatory factor analysis, item response theory, and multidimensional scaling were used to rank order activities. The distribution method produced upper quartiles based on standard deviation width. Select activities were relatively concordant for six life goals using the four methods, underscoring the uniformity and convergence of these different approaches. All four methods provided evidence of the uniformity of the select 11 activities. Findings are discussed in terms of the composition of adolescent life goals, their rank-order consistency across different weighting schemes, and their conceptual importance as we learn more about what youth consider relevant activities as they pursue their life goals. CI - Copyright (c) 2026 Scheier, Hansen and Komarc. FAU - Scheier, Lawrence M AU - Scheier LM AD - Prevention Strategies LLC, Greensboro, NC, United States. AD - LARS Research Institute, Sun City, AZ, United States. FAU - Hansen, William B AU - Hansen WB AD - Prevention Strategies LLC, Greensboro, NC, United States. FAU - Komarc, Martin AU - Komarc M AD - Univerzita Karlova, Prague, Czechia. LA - eng GR - R43 AA031941/AA/NIAAA NIH HHS/United States PT - Journal Article DEP - 20260317 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13036117 OTO - NOTNLM OT - activities OT - adolescence OT - life goals OT - psychometrics OT - values OT - weighting COIS- LS and WH are employed by the Prevention Strategies LLC, Greensboro, United States, a Small business concern operating as an LLC and that conducts research in health promotion and disease prevention. Neither of the authors are part of the IRB review process, which is conducted strictly by outside non-affiliated members having no connection to the research or grant funding process. The remaining author declares that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/04/02 06:31 MHDA- 2026/04/02 06:32 PMCR- 2026/03/17 CRDT- 2026/04/02 04:38 PHST- 2025/11/19 00:00 [received] PHST- 2026/02/03 00:00 [revised] PHST- 2026/02/06 00:00 [accepted] PHST- 2026/04/02 06:32 [medline] PHST- 2026/04/02 06:31 [pubmed] PHST- 2026/04/02 04:38 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1685340 [doi] PST - epublish SO - Front Psychol. 2026 Mar 17;17:1685340. doi: 10.3389/fpsyg.2026.1685340. eCollection 2026. PMID- 41924059 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260402 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Protocol for AI-based prediction of problematic digital technology use among Indian youth: a Centre for Advanced Research on Addictive Behaviours initiative. PG - 1754046 LID - 10.3389/fpsyg.2026.1754046 [doi] LID - 1754046 AB - BACKGROUND: Artificial intelligence (AI) and machine learning have an important role in mental health research by helping to predict and prevent digital addiction and problematic digital technology use. These include behaviors linked with internet, smartphones, gaming, social media, gambling, over-the-top (OTT) platforms watching, pornography watching, shopping/ buying, and excessive screen time. OBJECTIVE: This multi-center study aims to develop and validate an AI-based predictive model to identify Indian youth at risk of problematic use of digital technology and associated psychological outcomes such as stress, anxiety, depression, and addiction. The study corresponds to one of the objectives of the Centre for Advanced Research on Addictive Behaviours (CAR-AB) initiative. METHODS: Students aged >/=12 years from schools and colleges across six Indian sites (New Delhi, Bhopal, Patna, Puducherry, Rishikesh, and Shillong) will be recruited. Data will be collected on demographic, psychological, behavioral, cognitive, socio-environmental, and digital phenotype correlates using validated instruments. Machine-learning models, including ensemble and deep-learning methods, will be trained, validated, and interpreted using explainable AI techniques. EXPECTED OUTCOMES: The study will develop a validated and interpretable predictive model for early detection of vulnerability to problematic use of digital technology. Findings are expected to inform targeted interventions, guide digital-wellness policies, and support the integration of predictive tools within educational, work, and community settings. CI - Copyright (c) 2026 Balhara, Ranjan, Sarkar, Kaur, Ganesh, Kattimani, Saxena, Das, Dhiman, Bhargava, Joshi, Majumdar, Singh and Patra. FAU - Balhara, Yatan Pal Singh AU - Balhara YPS AD - Behavioral Addictions Clinic (BAC) and Centre for Advanced Research on Addictive Behaviours (CAR-AB), National Drug Dependence Treatment Centre (NDDTC), All India Institute of Medical Sciences (AIIMS), New Delhi, India. FAU - Ranjan, Rajeev AU - Ranjan R AD - All India Institute of Medical Sciences, Patna, India. FAU - Sarkar, Siddharth AU - Sarkar S AD - AIIMS, New Delhi, India. FAU - Kaur, Simran AU - Kaur S AD - Department of Physiology, All India Institute of Medical Sciences (AIIMS), New Delhi, India. FAU - Ganesh, Ragul AU - Ganesh R AD - Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Puducherry, India. FAU - Kattimani, Shivanand AU - Kattimani S AD - Jawaharlal Institute of Postgraduate Medical Education & Research (JIPMER), Puducherry, India. FAU - Saxena, Vandena AU - Saxena V AD - CIE, Department of Education, University of Delhi, New Delhi, India. FAU - Das, Subhash AU - Das S AD - Department of Psychiatry, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences (NEIGRIHMS), Shillong, India. FAU - Dhiman, Vishal AU - Dhiman V AD - All India Institute of Medical Sciences, Rishikesh, India. FAU - Bhargava, Rachna AU - Bhargava R AD - AIIMS, New Delhi, India. FAU - Joshi, Tanmay AU - Joshi T AD - All India Institute of Medical Sciences, Bhopal, India. FAU - Majumdar, Anindo AU - Majumdar A AD - All India Institute of Medical Sciences, Bhopal, India. FAU - Singh, Swarndeep AU - Singh S AD - Vardhman Mahavir Medical College (VMMC), Safdarjung Hospital, New Delhi, India. FAU - Patra, Bichitra Nanda AU - Patra BN AD - Department of Psychiatry, AIIMS, New Delhi, India. LA - eng PT - Journal Article DEP - 20260317 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13036647 OTO - NOTNLM OT - AI-based predictive model OT - addiction OT - anxiety OT - depression OT - digital addiction OT - machine learning OT - problematic technology use OT - youth mental health COIS- YB is associated with Behavioral Addictions Clinic. He leads the Centre for Advanced Research on Addictive Behaviours (CAR-AB). He conducts research on addictive behaviors and other mental health issues. He reviews/edits journal articles and makes presentations on addictive behaviors. He offers advice as a technical expert on addictive behaviors to various not-for-profit entities. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/04/02 06:30 MHDA- 2026/04/02 06:31 PMCR- 2026/03/17 CRDT- 2026/04/02 04:38 PHST- 2025/11/25 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/02/03 00:00 [accepted] PHST- 2026/04/02 06:31 [medline] PHST- 2026/04/02 06:30 [pubmed] PHST- 2026/04/02 04:38 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1754046 [doi] PST - epublish SO - Front Psychol. 2026 Mar 17;17:1754046. doi: 10.3389/fpsyg.2026.1754046. eCollection 2026. PMID- 41922936 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260714 IS - 2168-6602 (Electronic) IS - 0890-1171 (Linking) VI - 40 IP - 4 DP - 2026 May TI - Urban Green Space and Mental Health: Mediating Roles of Physical Activity and Social Cohesion. PG - 459-470 LID - 10.1177/08901171251388878 [doi] AB - PurposeThis study investigates the relationship between urban green spaces (UGS) and residents' mental health in Dhaka, Bangladesh, with a focus on the mediating roles of social cohesion and physical activity.DesignMultilevel regression and mediation analysis with cross-sectional data were constructed.Setting10 UGS in Dhaka were selected based on spatial variation.SampleA total of 276 adult residents (response rate: 85.2%) were surveyed using quota sampling to ensure demographic diversity.MeasuresThe Short Warwick-Edinburgh Mental Wellbeing Scale (SWEMWBS) was used for mental health assessment, validity scales for social cohesion and IPAQ-SF for physical activity. UGS accessibility and quality were evaluated using NDVI, GIS buffers, and on-site audits.AnalysisMultilevel linear regression and Sobel tests were employed to examine direct and mediated effects of UGS on mental health.ResultsUGS-level factors explained 18% of the variance in mental health. UGS accessibility (beta = 0.285***), safety (beta = 0.212***), and amenities (beta = 0.220***) were positively associated with mental health. Social cohesion (Z = 2.82***) and physical activity (Z = 2.15**) partially mediated these relationships.ConclusionUGS enhances mental health in dense urban environments through both direct and mediated pathways. Subgroup analysis reveals that high and medium-quality UGS have more substantial positive effects through physical activity and social cohesion on mental health. In contrast, the impact of low-quality UGS's is minor and insignificant. Respondents with higher education and income benefit more from UGS on their mental health. Future research using longitudinal data or experimental designs could enhance the robustness of causation. FAU - Ahmad, Maruf AU - Ahmad M AUID- ORCID: 0000-0002-0438-8028 AD - School of Public Policy and Administration, Xi'an Jiaotong University, Xi'an, Shaanxi, China. RINGGOLD: 12480 AD - Rural Development Academy (RDA), Bogura, Bangladesh. FAU - Du, Jinfeng AU - Du J AUID- ORCID: 0000-0001-5379-6813 AD - School of Public Policy and Administration, Xi'an Jiaotong University, Xi'an, Shaanxi, China. RINGGOLD: 12480 FAU - Rashid, Md Jubaer AU - Rashid MJ AUID- ORCID: 0009-0009-9816-783X AD - Sustainability Management, ICLEI South Asia, Dhaka, Bangladesh. LA - eng PT - Journal Article DEP - 20251014 PL - United States TA - Am J Health Promot JT - American journal of health promotion : AJHP JID - 8701680 SB - IM MH - Humans MH - *Mental Health/statistics & numerical data MH - Cross-Sectional Studies MH - *Exercise/psychology MH - Adult MH - Bangladesh MH - Female MH - Male MH - *Parks, Recreational MH - *Environment Design MH - Middle Aged MH - Socioeconomic Factors MH - Residence Characteristics MH - Urban Population MH - Neighborhood Characteristics MH - Young Adult MH - Adolescent OTO - NOTNLM OT - Dhaka OT - NDVI OT - mediation analysis OT - mental health OT - multilevel modeling OT - physical activity OT - social cohesion OT - urban green space OT - urban green spaces (UGS) COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/04/02 00:29 MHDA- 2026/04/02 06:30 CRDT- 2026/04/01 23:52 PHST- 2026/04/02 06:30 [medline] PHST- 2026/04/02 00:29 [pubmed] PHST- 2026/04/01 23:52 [entrez] AID - 10.1177/08901171251388878 [doi] PST - ppublish SO - Am J Health Promot. 2026 May;40(4):459-470. doi: 10.1177/08901171251388878. Epub 2025 Oct 14. PMID- 41921285 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260806 IS - 1873-3379 (Electronic) IS - 0891-4222 (Linking) VI - 171 DP - 2026 Apr TI - Virtual reality interventions for physical activity and stress reduction in neurodevelopmental disorder family contexts: A scoping review (2015-2025). PG - 105275 LID - S0891-4222(26)00070-3 [pii] LID - 10.1016/j.ridd.2026.105275 [doi] AB - BACKGROUND: Children with neurodevelopmental disorders (NDDs) and their families face barriers to physical activity and often accumulate excessive sedentary time. Virtual reality (VR) offers a promising modality to promote active engagement. OBJECTIVE: This scoping review mapped studies using immersive VR nature simulations for stress reduction in NDD family contexts (Tier 1) and recreation-focused VR supporting physical activity (Tier 2). METHODS: Guided by the JBI Manual and PRISMA-ScR, we searched PubMed, CINAHL, Web of Science, and APA PsycInfo (2015-2025). Searches were executed Oct 30-Nov 1, 2025. Strategies combined VR with nature/outdoor, pediatric/caregiver, and NDD terms. Two reviewers screened and charted data. RESULTS: Of 101 records identified, 32 duplicates were removed and 69 records were screened; 2 studies met inclusion criteria. A caregiver pilot (Tier 1) using a single 15-minute VR nature session showed immediate mood improvements and reduced perceived stress at days 3 and 7, with no serious adverse events. A school-based feasibility study (Tier 2) demonstrated that supervised VR exergaming can achieve moderate-intensity exercise. CONCLUSIONS: VR-enabled interventions appear feasible for caregiver stress reduction and promoting physical activity in children with disabilities. Evidence remains limited; comparative trials examining VR's role in active lifestyle promotion are needed. IMPLICATIONS: Practitioners can integrate VR into structured service delivery. Research should examine dose-response relationships, physiological endpoints, and equity-oriented implementation to advance lifestyle interventions for NDD populations. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Kubota, Kazumi AU - Kubota K AD - Research Organization, Shimonoseki City University, Shimonoseki, Yamaguchi, Japan; Department of Healthcare Information Management, The University of Tokyo Hospital, Tokyo, Tokyo, Japan. Electronic address: kkubota@m.u-tokyo.ac.jp. FAU - Tsuda, Satoko AU - Tsuda S AD - College of Life and Health Sciences, Chubu University, Kasugai, Aichi, Japan. Electronic address: s-tsuda@fsc.chubu.ac.jp. FAU - Sugimura, Ayumi AU - Sugimura A AD - Nursing Course, Gifu University Graduate School of Medicine, Gifu, Gifu, Japan. Electronic address: sugimura.ayumi.e4@f.gifu-u.ac.jp. FAU - Fujihara, Satoko AU - Fujihara S AD - Research Department, Institute for Health Economics and Policy, Minato-ku, Tokyo, Japan. Electronic address: satoko.fujihara@ihep.jp. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260331 PL - United States TA - Res Dev Disabil JT - Research in developmental disabilities JID - 8709782 SB - IM MH - Humans MH - *Virtual Reality MH - *Stress, Psychological/therapy/prevention & control MH - *Neurodevelopmental Disorders/psychology MH - *Exercise/psychology MH - Child MH - *Caregivers/psychology OTO - NOTNLM OT - Exergaming OT - Immersive technology OT - Implementation OT - Parental stress OT - Simulated nature OT - Therapeutic recreation COIS- Declaration of Competing Interest The authors declare no conflicts of interest. EDAT- 2026/04/01 18:30 MHDA- 2026/04/11 00:32 CRDT- 2026/04/01 18:01 PHST- 2025/11/25 00:00 [received] PHST- 2026/01/30 00:00 [revised] PHST- 2026/03/25 00:00 [accepted] PHST- 2026/04/11 00:32 [medline] PHST- 2026/04/01 18:30 [pubmed] PHST- 2026/04/01 18:01 [entrez] AID - S0891-4222(26)00070-3 [pii] AID - 10.1016/j.ridd.2026.105275 [doi] PST - ppublish SO - Res Dev Disabil. 2026 Apr;171:105275. doi: 10.1016/j.ridd.2026.105275. Epub 2026 Mar 31. PMID- 41920929 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 4 DP - 2026 TI - Unveiling the chain mediation model of sleep quality and fatigue in linking subjective exercise experience to depression in adolescent. PG - e0333460 LID - 10.1371/journal.pone.0333460 [doi] LID - e0333460 AB - While the positive correlation between physical exercise and depression has been widely replicated in cross-sectional research, the prognostic value of subjective exercise experience for depression continues to be disputed, and the mediating processes are not well understood. This study aims to elucidate the predictive role of subjective exercise experience in depression and examine the chain mediating effects of sleep quality and fatigue. We administered validated self-report questionnaires to assess these constructs in a sample of 538 Chinese high school students. The results demonstrated that adolescents' depressive symptoms are influenced by subjective exercise experience, and this effect mediated through two independent pathways: sleep quality and fatigue. Moreover, subjective exercise experience can predict adolescent depression via either the sleep quality pathway or the fatigue pathway. The identification of mediating dual pathways provides empirical support for developing targeted exercise interventions that specifically address sleep disturbances and fatigue management in depressed adolescents. CI - Copyright: (c) 2026 Li et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Li, Xiaoyu AU - Li X AD - School of Physical Education, University of Jinan, Jinan, Shan Dong, China. FAU - Yang, Qian AU - Yang Q AD - School of Physical Education, University of Jinan, Jinan, Shan Dong, China. FAU - Qi, Ziyang AU - Qi Z AD - School of Education and Psychology, University of Jinan, Jinan, Shan Dong, China. FAU - Ma, Changhao AU - Ma C AD - School of Physical Education, University of Jinan, Jinan, Shan Dong, China. FAU - Qi, Shenghua AU - Qi S AD - School of Physical Education, University of Jinan, Jinan, Shan Dong, China. FAU - Ji, Wenliang AU - Ji W AUID- ORCID: 0009-0005-2138-0860 AD - School of Physical Education, University of Jinan, Jinan, Shan Dong, China. LA - eng PT - Journal Article DEP - 20260401 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adolescent MH - *Fatigue/physiopathology/psychology MH - *Depression/physiopathology MH - *Exercise/psychology MH - *Sleep Quality MH - Female MH - Male MH - Surveys and Questionnaires MH - Self Report PMC - PMC13043057 EDAT- 2026/04/01 18:30 MHDA- 2026/04/01 18:31 PMCR- 2026/04/01 CRDT- 2026/04/01 13:53 PHST- 2025/09/19 00:00 [received] PHST- 2026/03/03 00:00 [accepted] PHST- 2026/04/01 18:31 [medline] PHST- 2026/04/01 18:30 [pubmed] PHST- 2026/04/01 13:53 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - PONE-D-25-44933 [pii] AID - 10.1371/journal.pone.0333460 [doi] PST - epublish SO - PLoS One. 2026 Apr 1;21(4):e0333460. doi: 10.1371/journal.pone.0333460. eCollection 2026. PMID- 41919969 OWN - NLM STAT- MEDLINE DCOM- 20260702 LR - 20260702 IS - 1531-698X (Electronic) IS - 1040-8703 (Linking) VI - 38 IP - 4 DP - 2026 Aug 1 TI - Artificial intelligence in pediatric endocrinology: clinical applications, governance, and future directions. PG - 409-416 LID - 10.1097/MOP.0000000000001564 [doi] AB - PURPOSE OF REVIEW: Artificial intelligence has transitioned from theoretical promise to practical implementation across medicine including pediatric endocrinology. This review examines artificial intelligence applications across diabetes care, obesity management, thyroid disorders, growth and puberty, and bone age assessment followed by discussion of limitations and future directions. RECENT FINDINGS: Artificial intelligence-driven tools ranging from machine learning algorithms to multimodal large language models enable personalized risk prediction, diagnostic support, and treatment optimization. Human-in-the-Loop frameworks enhance safety by integrating computational efficiency with clinician oversight. In diabetes, artificial intelligence supports glycemic forecasting, automated insulin delivery, complication screening, and digital twin modeling for therapeutic discovery. In obesity, thyroid disease, growth disorders, and bone age assessment, artificial intelligence enhances diagnostic accuracy, risk stratification, and clinical workflow efficiency. However, widespread implementation raises concerns regarding algorithmic bias, data privacy, transparency, regulatory oversight, and health equity. Addressing these limitations through explainable artificial intelligence, federated learning, and continuous performance monitoring is essential. SUMMARY: Artificial intelligence should be viewed as an augmentative tool that enhances clinical judgment in pediatric endocrinology. Preparing the next generation of pediatric endocrinologists will require intentional integration of artificial intelligence literacy into training programs, equipping clinicians to critically evaluate algorithms, interpret outputs responsibly, and participate in the ethical development of future artificial intelligence-enabled tools. CI - Copyright (c) 2026 Wolters Kluwer Health, Inc. All rights reserved. FAU - Sasidharan Pillai, Sabitha AU - Sasidharan Pillai S AD - Center for Endocrinology, Diabetes and Metabolism, Children's Hospital Los Angeles. AD - Department of Pediatrics, Keck School of Medicine, University of Southern California, Los Angeles, California. FAU - Ashraf, Ambika P AU - Ashraf AP AD - Department of Pediatrics, The University of Alabama at Birmingham, Birmingham, Alabama, USA. LA - eng PT - Journal Article PT - Review DEP - 20260330 PL - United States TA - Curr Opin Pediatr JT - Current opinion in pediatrics JID - 9000850 SB - IM MH - Humans MH - *Artificial Intelligence/trends MH - *Endocrinology/trends/methods MH - *Pediatrics/trends/methods MH - Child MH - Federated Learning OTO - NOTNLM OT - Human-in-the-Loop OT - artificial intelligence OT - clinical decision support systems OT - pediatric endocrinology EDAT- 2026/04/01 12:31 MHDA- 2026/07/02 06:39 CRDT- 2026/04/01 09:23 PHST- 2026/07/02 06:39 [medline] PHST- 2026/04/01 12:31 [pubmed] PHST- 2026/04/01 09:23 [entrez] AID - 00008480-202608000-00013 [pii] AID - 10.1097/MOP.0000000000001564 [doi] PST - ppublish SO - Curr Opin Pediatr. 2026 Aug 1;38(4):409-416. doi: 10.1097/MOP.0000000000001564. Epub 2026 Mar 30. PMID- 41919929 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260716 IS - 1938-1344 (Electronic) IS - 0190-6011 (Linking) VI - 56 IP - 4 DP - 2026 Apr TI - Is a Neuromuscular Training Warm-up Enough for Injury and Concussion Prevention in High School Girl Rugby Players? PG - 261-271 LID - 10.2519/jospt.2026.13373 [doi] AB - OBJECTIVE: To evaluate the effectiveness of a rugby-specific neuromuscular training (NMT) warm-up on injury and concussion rates in Canadian high school girls' rugby. DESIGN: Quasi-experimental study. METHODS: Two high school girls' rugby cohorts (control seasons 2018, 2019; intervention seasons 2022, 2023) were compared using validated injury surveillance methodology. Coaches attended a rugby-specific NMT warm-up workshop before the intervention seasons. Outcomes of interest were injury and concussion. Multilevel Poisson regression analyses were used to estimate incidence rate ratios (IRRs) (95% confidence intervals [CIs]) comparing intervention and control cohorts, adjusted for injury history and rugby playing experience, offset by match hours and random effects (team and individual level). RESULTS: There were 409 player seasons (13 teams) in control seasons and 483 player seasons (17 teams) in intervention seasons. Concussions accounted for 41% (62/150) of match injuries in control seasons and 31% (70/226) in intervention seasons. Intention-to-treat (ITT) and per-protocol (PP) analyses demonstrated no differences in match injury rates (IRR(ITT): 1.06; 95% CI: 0.75, 1.50; IRR(PP): 0.91; 95% CI: 0.69, 1.21) or match concussions rates (IRR(ITT): 0.79; 95% CI: 0.52, 1.20; IRR(PP): 0.74; 95% CI: 0.47, 1.17) between intervention and control seasons. Head-match injury burden (mean difference, -194 days of time-loss per 1000 match hours; 95% CI: -349, -39) and all-training injury burden (mean difference, -17 days of time-loss per 1000 match hours; 95% CI: -27, -7) were lower in the intervention seasons. CONCLUSION: While no statistically significant differences were found in match injury or concussion rates in the intervention and control seasons, regardless of adherence level, there was a clinically relevant 21% lower match concussion rate and lower match-head injury and all-training injury burden with NMT warm-up use. J Orthop Sports Phys Ther 2026;56(4):261-271. Epub 2 March 2026. doi:10.2519/jospt.2026.13373. FAU - Shill, Isla J AU - Shill IJ FAU - van den Berg, Carla AU - van den Berg C FAU - West, Stephen W AU - West SW FAU - Galarneau, Jean-Michel AU - Galarneau JM FAU - Fraser, Kristina AU - Fraser K FAU - Schneider, Kathryn J AU - Schneider KJ FAU - Pasanen, Kati AU - Pasanen K FAU - Pike, Ian AU - Pike I FAU - Palmer, Debbie AU - Palmer D FAU - Stokes, Keith A AU - Stokes KA FAU - Hagel, Brent E AU - Hagel BE FAU - Emery, Carolyn A AU - Emery CA LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Orthop Sports Phys Ther JT - The Journal of orthopaedic and sports physical therapy JID - 7908150 SB - IM MH - Humans MH - Female MH - *Football/injuries MH - *Brain Concussion/prevention & control/epidemiology MH - Adolescent MH - *Warm-Up Exercise MH - *Athletic Injuries/prevention & control/epidemiology MH - Canada/epidemiology MH - Incidence OTO - NOTNLM OT - concussion OT - girl OT - injury OT - injury prevention OT - neuromuscular training warm-up OT - rugby union EDAT- 2026/04/01 12:32 MHDA- 2026/04/01 12:33 CRDT- 2026/04/01 09:02 PHST- 2026/04/01 12:33 [medline] PHST- 2026/04/01 12:32 [pubmed] PHST- 2026/04/01 09:02 [entrez] AID - 10.2519/jospt.2026.13373 [doi] PST - ppublish SO - J Orthop Sports Phys Ther. 2026 Apr;56(4):261-271. doi: 10.2519/jospt.2026.13373. PMID- 41917889 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Apr 1 TI - Educational practices for promoting healthy hydration in primary education in the face of climate change: a systematic review of the literature. LID - 10.1186/s12887-026-06773-y [doi] LID - 431 AB - Climate change is increasing children's exposure to heat and, consequently, their risk of dehydration during their primary school years. Yet hydration education is not consistently embedded in education policy or primary curricula. This systematic review, reported in accordance with PRISMA 2020, examined school-based educational practices designed to promote healthy hydration in Primary Education (6 to 12 years). A search was conducted in the Web of Science Core Collection on January 29th, 2025 for studies published between 2015 and 2024. Two reviewers independently screened records and assessed risk of bias using design-appropriate tools (RoB 2, ROBINS-I, and JBI checklists). Given the substantial heterogeneity in intervention components and outcome indicators, a narrative synthesis was performed. Twelve studies were included, spanning randomized and non-randomized interventions and observational and qualitative or documentary designs across diverse school contexts. Overall, multi-component approaches, particularly those combining improved access to drinking water with classroom-based educational activities and routine supports, were associated with increased water intake, and when measured, improved physiological hydration indicators. Evidence for broader outcomes, including cognitive or academic measures and sustainability-related awareness, was mixed and dependent on the outcome assessed. Risk of bias ranged from low to high; common limitations included reliance on self-reported intake, short intervention duration, limited control for confounding in non-randomized designs, and scarce medium- to long-term follow-up. Future research should prioritize standardized and validated hydration measures, clearer specification of educational strategies, including teacher roles and competencies, and longer follow-up to strengthen the evidence base under climate-related heat risks. FAU - Fornons-Casol, Laura AU - Fornons-Casol L AUID- ORCID: 0009-0008-0373-4225 AD - Department of Education Sciences, Universitat de Lleida, C/ Av. Estudi General 4, Lleida, 25001, Spain. laura.fornons@udl.cat. FAU - Ramos-Pla, Anabel AU - Ramos-Pla A AUID- ORCID: 0000-0001-5437-150X AD - Department of Education Sciences, Universitat de Lleida, C/ Av. Estudi General 4, Lleida, 25001, Spain. FAU - Olondriz-Valverde, Aleix AU - Olondriz-Valverde A AUID- ORCID: 0000-0001-6456-388X AD - Department of Education Sciences, Universitat de Lleida, C/ Av. Estudi General 4, Lleida, 25001, Spain. FAU - Selva-Pareja, Laia AU - Selva-Pareja L AUID- ORCID: 0000-0002-7443-7470 AD - Department of Nursing and Physiotherapy, Universitat de Lleida, C/ de Montserrat Roig 2, Lleida, 25198, Spain. LA - eng GR - (Project Code: 2023 CLIMA 00047)/Department of Research and Universities, the Department of Climate Action, Food and Rural Agenda, and the Climate Fund of the Generalitat de Catalunya/ PT - Journal Article PT - Systematic Review DEP - 20260401 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Climate Change MH - *Dehydration/prevention & control MH - Child MH - *Health Promotion/methods MH - Schools MH - Drinking PMC - PMC13169862 OTO - NOTNLM OT - Health education OT - Hydration OT - Primary Education OT - School-based intervention OT - Systematic review COIS- Declarations. Ethics approval and consent to participate: The project HIDROPONENT received a favourable approval from the Comite de Etica de Investigacion y Transferencia, University of Lleida, on 9 December 2025, reference number CERT198. The present manuscript is a systematic review of published literature and did not involve human participants or the collection of new personal data; therefore, consent to participate was not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/04/01 07:04 MHDA- 2026/06/27 12:37 PMCR- 2026/04/01 CRDT- 2026/04/01 01:18 PHST- 2026/01/22 00:00 [received] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/06/27 12:37 [medline] PHST- 2026/04/01 07:04 [pubmed] PHST- 2026/04/01 01:18 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - 10.1186/s12887-026-06773-y [pii] AID - 6773 [pii] AID - 10.1186/s12887-026-06773-y [doi] PST - epublish SO - BMC Pediatr. 2026 Apr 1;26(1):431. doi: 10.1186/s12887-026-06773-y. PMID- 41917678 OWN - NLM STAT- MEDLINE DCOM- 20260614 LR - 20260902 IS - 1526-3231 (Electronic) IS - 0749-8063 (Linking) VI - 42 IP - 6 DP - 2026 Jun TI - Smaller Lateral-to-Medial Tibial Plateau Ratios Are Strongly Correlative With Anterior Cruciate Ligament Tears and Reconstruction Failures. PG - 1030-1038 LID - 10.1002/arj.70149 [doi] AB - PURPOSE: To compare the anterior-posterior distance ratio of the lateral-to-medial tibial plateau (LTP/MTP) among 3 patient groups: those with intact anterior cruciate ligaments (ACLi), primary ACL tears (ACLp), and failed ACL reconstructions (ACLf). METHODS: We retrospectively identified skeletally mature patients (16-40 years) who underwent knee magnetic resonance imaging between May 2013 and March 2022. Patients were included if they had adequate radiographs and magnetic resonance imaging available and were required to have a minimum of 2 years of follow-up for confirmation of ACL status. The anterior to posterior distance of the LTP and anterior to posterior distance of the MTP were measured on axial T1 magnetic resonance imaging to compute LTP/MTP. Tibial eminence width was measured between tibial spine peaks on coronal T1 magnetic resonance imaging. Posterior tibial slope (PTS) was calculated on lateral knee radiographs. Multivariate logistic regression identified predictors of ACLp and ACLf. RESULTS: Demographic characteristics: age, sex, and body mass index were no different between groups. The intraclass correlation coefficients for the morphometric measurements ranged from 0.750 to 0.902 indicating good to excellent agreement among the 3 raters and intrarater reliability testing. Mean PTS was significantly higher in ACLf (12.1 +/- 2.9 degrees ) compared with ACLi (10.3 +/- 2.0 degrees ) and ACLp (10.6 +/- 2.6 degrees ) (P < .001). The mean LTP/MTP ratio was significantly lower in ACLp (0.79 +/- 0.06) and ACLf (0.77 +/- 0.06) versus ACLi (0.84 +/- 0.06) (P < .001). In logistic regression comparing ACLp to ACLi, a lower LTP/MTP ratio was the only significant morphologic predictor (odds ratio [OR], 0.87; 95% confidence interval [CI]: 0.80-0.95). In contrast, when compared with ACLi, ACLf were significantly predicted by a lower LTP/MTP ratio (OR, 0.82; 95% CI: 0.74-0.91), higher PTS (OR, 1.38; 95% CI: 1.14-1.73), and narrower tibial eminence width (OR, 0.70; 95% CI: 0.51-0.94). A direct comparison found that higher PTS, narrower tibial eminence width, and higher body mass index were significantly associated with ACLf versus a ACLp. For every 1-degree increase in PTS, the odds of a retear versus ACL increased by 38%. CONCLUSIONS: This study identifies the LTP/MTP ratio as a key anatomical risk factor for ACL injury. Specifically, a smaller LTP/MTP ratio was associated with a significantly higher odds of both primary ACL tears and subsequent retears relative to individuals without ACL injury. LEVEL OF EVIDENCE: Level III, retrospective comparative study. CI - (c) 2026 The Author(s). Arthroscopy published by Wiley Periodicals LLC on behalf of the Arthroscopy Association of North America. FAU - Ihn, Hansel E AU - Ihn HE AD - Department of Orthopaedics, University of Utah, Salt Lake City, Utah, U.S.A. FAU - Hunter, Collin D R AU - Hunter CDR AUID- ORCID: 0000-0001-7677-0667 AD - Department of Orthopaedics, University of Utah, Salt Lake City, Utah, U.S.A. FAU - Mortensen, Alexander J AU - Mortensen AJ AD - Department of Orthopaedics, University of Utah, Salt Lake City, Utah, U.S.A. FAU - Johnson, Benjamin T AU - Johnson BT AUID- ORCID: 0000-0002-5360-732X AD - Department of Orthopaedics, University of Utah, Salt Lake City, Utah, U.S.A. FAU - Eddington, Devin AU - Eddington D AD - Division of Epidemiology, Department of Internal Medicine, University of Utah, Salt Lake City, Utah, U.S.A. FAU - Aoki, Stephen K AU - Aoki SK AD - Department of Orthopaedics, University of Utah, Salt Lake City, Utah, U.S.A. FAU - Ernat, Justin J AU - Ernat JJ AUID- ORCID: 0000-0003-2306-7745 AD - Department of Orthopaedics, University of Utah, Salt Lake City, Utah, U.S.A. LA - eng PT - Journal Article DEP - 20260331 PL - United States TA - Arthroscopy JT - Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association JID - 8506498 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - *Anterior Cruciate Ligament Injuries/surgery/diagnostic imaging/pathology MH - *Anterior Cruciate Ligament Reconstruction MH - Magnetic Resonance Imaging MH - Retrospective Studies MH - *Tibia/diagnostic imaging/pathology/anatomy & histology MH - Treatment Failure EDAT- 2026/04/01 07:04 MHDA- 2026/06/15 11:33 CRDT- 2026/04/01 00:05 PHST- 2025/05/22 00:00 [received] PHST- 2025/11/06 00:00 [accepted] PHST- 2026/06/15 11:33 [medline] PHST- 2026/04/01 07:04 [pubmed] PHST- 2026/04/01 00:05 [entrez] AID - 10.1002/arj.70149 [doi] PST - ppublish SO - Arthroscopy. 2026 Jun;42(6):1030-1038. doi: 10.1002/arj.70149. Epub 2026 Mar 31. PMID- 41917629 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260714 IS - 0065-2598 (Print) IS - 0065-2598 (Linking) VI - 1505 DP - 2026 TI - Assessment of Adolescent Growth and Development. PG - 145-158 LID - 10.1007/978-981-95-7000-3_7 [doi] AB - Evaluating growth and development is crucial to understanding the health status of adolescents. This assessment, through physical examination, requires healthcare experts and can be challenging due to subjectivity and privacy concerns. Similarly, psychosocial growth is subjective and also requires complex evaluations by professionals. This complexity makes physical growth assessment based on anthropometric measures a more useful and convenient indicator for monitoring growth. Therefore, anthropometric measurements should be assessed with more precise methods and calibrated equipment. Considerations of precision, reliability, and validity are essential for growth assessments when planning health strategies, nutritional status, and overall well-being. The study design should be carefully selected based on the objectives. An adequate sample size is also critical in capturing the true variability of the study population. Adolescents undergo a growth spurt due to prepuberty and puberty; thus, the development of growth centile charts necessitates appropriate assessment methodology and validations to effectively evaluate growth status and capture its variations. The differences, velocity, and acceleration charts are essential in creating reference growth centiles for a population, especially for adolescents. The appropriate statistical methodology, based on exploratory data analysis and modeling for estimating centiles, has fundamental implications. GAMLSS is a more flexible model that can capture the growth spurt due to puberty in adolescents, utilizing various distribution families, smoothing functions, and the ability to model each parameter with multiple covariates. Cross-validation enhances confidence in the generalizability of the statistical model and growth centiles for the target population. These growth centile charts are vital for early detection of growth disorders, nutritional assessments, monitoring, and informed decision-making in clinical and public health contexts. CI - (c) 2026. The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. FAU - Khurram, Haris AU - Khurram H AD - National University of Computer and Emerging Sciences, Chiniot-Faisalabad Campus, Faisalabad, Pakistan. haris.khurram@nu.edu.pk. LA - eng PT - Journal Article PT - Review PL - United States TA - Adv Exp Med Biol JT - Advances in experimental medicine and biology JID - 0121103 SB - IM MH - Humans MH - Adolescent MH - *Adolescent Development/physiology MH - Growth Charts MH - Puberty/physiology MH - Anthropometry/methods OTO - NOTNLM OT - Adolescents OT - GAMLSS OT - Growth assessment OT - Growth centiles OT - Growth charts OT - Nutrition status EDAT- 2026/04/01 07:04 MHDA- 2026/04/01 07:05 CRDT- 2026/04/01 00:04 PHST- 2026/04/01 07:05 [medline] PHST- 2026/04/01 07:04 [pubmed] PHST- 2026/04/01 00:04 [entrez] AID - 10.1007/978-981-95-7000-3_7 [doi] PST - ppublish SO - Adv Exp Med Biol. 2026;1505:145-158. doi: 10.1007/978-981-95-7000-3_7. PMID- 41917155 OWN - NLM STAT- MEDLINE DCOM- 20260520 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 31 TI - Quantitative comparison of explainable AI methods for interpreting deep learning-based classification of 3D gait kinematics. LID - 10.1038/s41598-026-46243-0 [doi] LID - 15560 AB - Gait disorders can be caused by various reasons including cerebral palsy and neuromuscular diseases. 3D clinical gait analysis (3DGA) serves as a valuable clinical tool to assess gait abnormalities. Our previous research introduced a diagnostic tool that combines deep learning (DL) with 3DGA to evaluate childhood gait disorders. It achieved a promising diagnostic accuracy ranging from 0.77 to 0.99 across different pathologies. However, the lack of transparency limits their adoption. This research seeks to unveil the critical features that drive these models' diagnoses, improving interpretability and building trust in their decision-making process. Four different explaining artificial intelligence (XAI) methods were applied: LIME, DeepLift, Integrated Gradients, and sequential feature selection. These methods were used on various network architectures applied to three separate datasets involving different gait disorders. The results show that the features highlighted by XAI methods are relevant and reliable for diagnostic purposes. Moreover, quantitative analysis indicated that Integrated Gradients is the most appropriate XAI method in this case. Further experiments demonstrate that using parts of the critical features can achieve better accuracy than using all of the features. In conclusion, this research identified the diagnostic basis of DL models through XAI methods, enhanced diagnostic accuracy by focusing on critical features, and improved clinicians' understanding and trust in the DL diagnostic tool. CI - (c) 2026. The Author(s). FAU - Lan, Zhengyang AU - Lan Z AD - Laboratoire de Traitement de l'Information Medicale INSERM U1101, Brest, France. AD - IMT Atlantique, LaTIM U1101 INSERM, Brest, France. FAU - Lempereur, Mathieu AU - Lempereur M AD - Laboratoire de Traitement de l'Information Medicale INSERM U1101, Brest, France. mathieu.lempereur@univ-brest.fr. AD - Universite de Bretagne Occidentale, Brest, France. mathieu.lempereur@univ-brest.fr. AD - CHU de Brest, Hopital Morvan, service de medecine physique et de readaptation, 2 avenue Foch, Brest cedex, Brest, 29609, France. mathieu.lempereur@univ-brest.fr. FAU - Aissa-El-Bey, Abdeldjalil AU - Aissa-El-Bey A AD - IMT Atlantique, UMR CNRS 6285, Lab-STICC, Brest, France. FAU - Brochard, Sylvain AU - Brochard S AD - Laboratoire de Traitement de l'Information Medicale INSERM U1101, Brest, France. AD - Universite de Bretagne Occidentale, Brest, France. AD - CHU de Brest, Hopital Morvan, service de medecine physique et de readaptation, 2 avenue Foch, Brest cedex, Brest, 29609, France. FAU - Rousseau, Francois AU - Rousseau F AD - Laboratoire de Traitement de l'Information Medicale INSERM U1101, Brest, France. AD - IMT Atlantique, LaTIM U1101 INSERM, Brest, France. LA - eng GR - ANR-19-CHIA-0015/ANR AI4CHILD Project/ PT - Comparative Study PT - Journal Article DEP - 20260331 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - *Deep Learning MH - *Biomechanical Phenomena MH - *Gait Analysis/methods MH - *Gait Disorders, Neurologic/diagnosis/etiology MH - Cerebral Palsy/complications MH - Humans MH - Child PMC - PMC13187468 OTO - NOTNLM OT - Cerebral palsy OT - Deep learning OT - Diagnostic tool OT - Explainable artificial intelligence (XAI) OT - Times series classification COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/04/01 00:29 MHDA- 2026/05/20 06:32 PMCR- 2026/03/31 CRDT- 2026/03/31 23:47 PHST- 2025/05/12 00:00 [received] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/05/20 06:32 [medline] PHST- 2026/04/01 00:29 [pubmed] PHST- 2026/03/31 23:47 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - 10.1038/s41598-026-46243-0 [pii] AID - 46243 [pii] AID - 10.1038/s41598-026-46243-0 [doi] PST - epublish SO - Sci Rep. 2026 Mar 31;16(1):15560. doi: 10.1038/s41598-026-46243-0. PMID- 41917087 OWN - NLM STAT- MEDLINE DCOM- 20260518 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 31 TI - Prediction of individual optimal drop height in drop jump from anthropometric and strength variables. LID - 10.1038/s41598-026-45266-x [doi] LID - 15270 AB - This study aimed to investigate the associations between individual optimal drop height (ODH), as determined by the reactive strength index (RSI) method, and selected anthropometric and strength parameters, and to develop a prediction model for ODH based on these variables. A total of 49 participants were recruited, and measurements included body height, body mass, maximal muscle strength (MSmax), lower limb stiffness, reactive strength ratio (RSR), countermovement jump (CMJ) height, and ODH. Pearson correlation analysis was conducted to examine the relationships between ODH and the assessed variables. A multiple linear regression model was constructed in a stepwise manner to predict individual ODH. Significant correlations were observed between ODH and relative MSmax (r = 0.827, P < 0.001), RSR (r = 0.703, P < 0.001), body mass (r = -0.481, P < 0.01), body height (r = -0.430, P < 0.01), and CMJ height (r = 0.487, P < 0.01). Relative MSmax, CMJ height and RSR collectively explained 78.4% of the variance in ODH (R(2) = 0.784). The final prediction equation was: ODH = -45.602+31.027*relative MS(max) +0.548*CMJ height +5.549*RSR (R(2) = 0.784, F (3, 36) = 48.190, p < 0.001). Coaches should consider body height, body mass, RSR, relative MSmax, and CMJ height when prescribing drop jump height. Moreover, an individual's ODH should be adjusted when changes in CMJ height or relative MSmax occur. Finally, this study provides a practical prediction equation for estimating individual ODH using relative MSmax and CMJ height as input variables. CI - (c) 2026. The Author(s). FAU - Xie, Yongmin AU - Xie Y AD - School of Strength and Conditioning Training, Beijing Sport University, Haidian, 100084, China. xieyongminbsu@163.com. FAU - Peng, Fan AU - Peng F AD - School of Strength and Conditioning Training, Beijing Sport University, Haidian, 100084, China. FAU - Pan, Xinyu AU - Pan X AD - School of Strength and Conditioning Training, Beijing Sport University, Haidian, 100084, China. FAU - Sun, Qinchang AU - Sun Q AD - School of Strength and Conditioning Training, Beijing Sport University, Haidian, 100084, China. LA - eng PT - Journal Article DEP - 20260331 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Cross-Sectional Studies MH - *Anthropometry/methods MH - *Body Mass Index MH - *Body Height/physiology MH - *Muscle Strength/physiology MH - *Exercise Test/methods/statistics & numerical data MH - Humans MH - Male MH - Adolescent MH - Young Adult MH - Athletes/statistics & numerical data MH - Athletic Performance/physiology MH - Plyometric Exercise/methods MH - Predictive Value of Tests MH - Reproducibility of Results MH - Regression Analysis PMC - PMC13181053 OTO - NOTNLM OT - Optimal drop height OT - Plyometric training OT - Reactive strength OT - Training intensity COIS- Decleartions. Competing interests: The authors declare no competing interests. EDAT- 2026/04/01 00:29 MHDA- 2026/05/18 00:30 PMCR- 2026/03/31 CRDT- 2026/03/31 23:39 PHST- 2025/08/10 00:00 [received] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/05/18 00:30 [medline] PHST- 2026/04/01 00:29 [pubmed] PHST- 2026/03/31 23:39 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - 10.1038/s41598-026-45266-x [pii] AID - 45266 [pii] AID - 10.1038/s41598-026-45266-x [doi] PST - epublish SO - Sci Rep. 2026 Mar 31;16(1):15270. doi: 10.1038/s41598-026-45266-x. PMID- 41916909 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260814 IS - 2160-7648 (Electronic) IS - 2160-763X (Print) IS - 2160-763X (Linking) VI - 15 IP - 4 DP - 2026 Apr TI - Single-Dose Bioequivalence Study of Elagolix Tablets 200 mg (Test Product) and Elagolix Tablets 200 mg (Reference Product) in Healthy Non-Pregnant, Non-Lactating Premenopausal Female Subjects Under Fasting Conditions. PG - e70053 LID - 10.1002/cpdd.70053 [doi] LID - e70053 AB - Elagolix is a short-acting oral gonadotropin-releasing hormone antagonist utilized for treating endometriosis-associated pain by rapidly suppressing gonadotropins and estradiol. Although well characterized in Western populations, clinical data regarding its use in Indian women remain limited. This study evaluated the pharmacokinetics, safety, and bioequivalence of a test 200 mg Elagolix tablet against a reference formulation under fasting conditions. The randomized, open-label, four-period crossover trial involved 60 healthy women aged 18-40 years who received single oral doses of either formulation. Plasma concentrations were monitored via validated UHPLC-MS/MS for 24 h post-dose. Fifty-nine participants completed the study, with results indicating rapid absorption (median T(max) 1.25-1.50 h) and a mean half-life of approximately 2.1-2.2 h. Bioequivalence was established as the 90% confidence intervals for key pharmacokinetic parameters-C(max), AUC(0-t), and AUC(0-infinity)-fell within the regulatory 80%-125% acceptance limits. Specifically, the median AUC(0-t) was 3341.23 ng h/mL for the test product compared to 3365.30 ng h/mL for the reference. Both formulations exhibited comparable safety profiles, with only five mild, resolvable adverse events reported. These findings confirm that the test formulation is bioequivalent to the reference standard, supporting its viability as a safe and effective therapeutic alternative. CI - (c) 2026 The Author(s). Clinical Pharmacology in Drug Development published by Wiley Periodicals LLC on behalf of American College of Clinical Pharmacology. FAU - Kumar, Sudershan AU - Kumar S AD - Sun Pharmaceutical Industries Limited, Mumbai, India. FAU - Khuroo, Arshad AU - Khuroo A AD - Sun Pharmaceutical Industries Limited, Mumbai, India. FAU - Quadros, Reshma AU - Quadros R AD - Sun Pharmaceutical Industries Limited, Mumbai, India. FAU - Dharmadhikari, Shruti AU - Dharmadhikari S AD - Sun Pharma Laboratories Limited, Mumbai, India. FAU - Khandhedia, Chintan AU - Khandhedia C AD - Sun Pharma Laboratories Limited, Mumbai, India. FAU - Puppalwar, Gaurav AU - Puppalwar G AD - Sun Pharma Laboratories Limited, Mumbai, India. FAU - Mane, Amey AU - Mane A AD - Sun Pharma Laboratories Limited, Mumbai, India. LA - eng GR - Sun Pharma Laboratories/ PT - Equivalence Trial PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Clin Pharmacol Drug Dev JT - Clinical pharmacology in drug development JID - 101572899 RN - 5B2546MB5Z (elagolix) RN - 0 (Hydrocarbons, Fluorinated) RN - 0 (Pyrimidines) RN - 0 (Tablets) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Young Adult MH - Administration, Oral MH - Area Under Curve MH - Cross-Over Studies MH - Fasting/blood MH - Half-Life MH - Healthy Volunteers MH - *Hydrocarbons, Fluorinated/pharmacokinetics MH - Premenopause/blood MH - *Pyrimidines/pharmacokinetics MH - Tablets MH - Tandem Mass Spectrometry MH - Therapeutic Equivalency PMC - PMC13038420 OTO - NOTNLM OT - bioequivalence OT - elagolix OT - endometriosis OT - pharmacokinetics OT - safety COIS- The authors are full-time employees of Sun Pharma. EDAT- 2026/04/01 00:29 MHDA- 2026/04/01 00:30 PMCR- 2026/04/01 CRDT- 2026/03/31 23:03 PHST- 2025/12/18 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/04/01 00:30 [medline] PHST- 2026/04/01 00:29 [pubmed] PHST- 2026/03/31 23:03 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - CPDD70053 [pii] AID - 10.1002/cpdd.70053 [doi] PST - ppublish SO - Clin Pharmacol Drug Dev. 2026 Apr;15(4):e70053. doi: 10.1002/cpdd.70053. PMID- 41916638 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 3 DP - 2026 Mar 31 TI - Quantitative and qualitative motion analysis for early detection of joint damage in haemophilia patients: study protocol for a pilot feasibility study at a German haemophilia treatment centre. PG - e108291 LID - 10.1136/bmjopen-2025-108291 [doi] LID - e108291 AB - INTRODUCTION: Joint bleeds are the most significant complication in haemophilia, leading to functional impairment and reduced quality of life. Repeated bleeding during early childhood can cause severe physical limitations in adulthood. Early detection of joint damage, combined with therapeutic interventions, has a huge impact on mobility, physical health and long-term quality of life. METHODS AND ANALYSIS: A novel markerless video motion analysis method using deep neural networks will be explored in this single-centre, prospective, longitudinal pilot feasibility study. The study will include children and young adults with haemophilia, as well as age-matched healthy controls. Standardised video recordings, the Haemophilia Joint Health Score (HJHS), clinical data, accelerometer-based physical activity tracking and questionnaires on quality of life and activity levels will be collected at baseline and after 12 months.For haemophilia patients, individual consultations will be held after each assessment to discuss joint health and possible interventions. Results will be compared with those of healthy participants to assess the method's feasibility and to explore outcome differences and correlations. The primary focus will be on evaluating the study's feasibility, practicability, acceptance, possible risks and data quality with regards to a potential future multicentre trial. ETHICS AND DISSEMINATION: The study was approved by the local Ethics Committee at the Medical Faculty and the University Hospital Tubingen (project No. 188/2023BO1, approval 5 July 2023, protocol version 2.1) and registered at the German Clinical Trials Register (registered 22 September 2023, https://drks.de/search/en/trial/DRKS00032707). Results will be shared at conferences and in peer-reviewed journals.This pilot study will explore the feasibility, practicability and acceptance of a protocol using artificial intelligence in gait analysis to identify patients at risk of early joint damage and to monitor the functional status of children and young adults with haemophilia in routine care. TRIAL REGISTRATION NUMBER: German Clinical Trials Registry (DRKS00032707). CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Schober, Sarah AU - Schober S AUID- ORCID: 0000-0003-4776-1790 AD - Clinic for Paediatrics and Adolescent Medicine, Paediatrics I - Haematology, Oncology, Gastroenterology, Nephrology, Rheumatology, University Hospital Tubingen, Tubingen, Germany. FAU - Hansmann, Sandra AU - Hansmann S AUID- ORCID: 0000-0002-7486-3090 AD - Clinic for Paediatrics and Adolescent Medicine, Paediatrics III - Neuropaediatrics, General Paediatrics, Diabetology, Endocrinology, Social Paediatrics, University Hospital Tubingen, Tubingen, Germany sandra.hansmann@med.uni-tuebingen.de. LA - eng PT - Journal Article DEP - 20260331 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Pilot Projects MH - *Hemophilia A/complications MH - Feasibility Studies MH - Germany MH - Child MH - Quality of Life MH - Prospective Studies MH - Adolescent MH - Male MH - Young Adult MH - Video Recording MH - Early Diagnosis MH - Child, Preschool MH - Joints MH - Research Design MH - *Joint Diseases/diagnosis/etiology MH - *Hemarthrosis/diagnosis/etiology MH - Longitudinal Studies PMC - PMC13052583 OTO - NOTNLM OT - Bleeding disorders & coagulopathies OT - Gait Analysis OT - PAEDIATRICS OT - Physical Fitness OT - Quality of Life COIS- Competing interests: The authors declare that they are affiliated with the University of Tubingen, which provided APC funding for this publication. The funders had no role in the study design; data collection, analysis or interpretation; manuscript preparation; or the decision to submit the manuscript for publication. The authors declare that they have no conflicts of interest relevant to the content of this research study. EDAT- 2026/04/01 00:29 MHDA- 2026/04/01 00:30 PMCR- 2026/03/31 CRDT- 2026/03/31 20:32 PHST- 2026/04/01 00:30 [medline] PHST- 2026/04/01 00:29 [pubmed] PHST- 2026/03/31 20:32 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - bmjopen-2025-108291 [pii] AID - 10.1136/bmjopen-2025-108291 [doi] PST - epublish SO - BMJ Open. 2026 Mar 31;16(3):e108291. doi: 10.1136/bmjopen-2025-108291. PMID- 41916565 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1940-8250 (Electronic) IS - 0279-5442 (Linking) VI - 46 IP - 2 DP - 2026 Apr 1 TI - Out-the-Door, Dinosaur: Assessing Health Literacy to Improve Discharge Education. PG - 47-53 LID - 10.4037/ccn2026298 [doi] AB - BACKGROUND: Identifying caregivers with limited health literacy is an organizational care issue. Health care organizations need to prepare nurses to identify low-literacy caregivers and to equip caregivers with tools to make informed care decisions. LOCAL PROBLEM: In a pediatric cardiovascular intensive care unit performing biventricular and single-ventricle repairs, caregiver satisfaction with understanding what was taught by nurses during hospitalization was below the national benchmark of 80%. Thirty-day readmission rates following surgical repair were above the national benchmark of 10%. METHODS: A quality improvement project was conducted. Nurses screened caregivers' health literacy within 24 hours of patient admission using a validated literacy screening tool. Nurses provided discharge education in 5 key areas: medication administration, wound care, cardiopulmonary resuscitation, nutrition, and need for additional medical care. Education was provided to the caregiver at the identified literacy level using the teach-back method. Data on project outcomes were collected via anonymous surveys and readmission rates were analyzed for trends in care management. RESULTS: Over a 12-month period, 150 caregivers were screened. Sixty-four percent of caregivers demonstrated adequate literacy, 23% displayed limited literacy, and 13% met criteria for low literacy. Caregiver satisfaction with discharge education during hospitalization increased to 100%, and caregivers indicated that they felt confident performing required posthospitalization tasks. Thirty-day readmission rates following surgical repair decreased by 1.8%. CONCLUSION: Increasing health literacy awareness is essential for improving patient health outcomes and empowering caregivers to make informed care decisions. Literacy tools can help nurses educate caregivers with limited health literacy to improve postdischarge care. CI - (c)2026 American Association of Critical-Care Nurses. FAU - de la Vega, Emily Garcia AU - de la Vega EG AD - Emily Garcia de la Vega is a pediatric critical care nurse, Loma Linda Children's Hospital, California. FAU - Hokama, Maureen AU - Hokama M AD - Maureen Hokama is a pediatric critical care nurse, Loma Linda Children's Hospital. FAU - Newcombe, Jennifer AU - Newcombe J AD - Jennifer Newcombe is a pediatric cardiothoracic nurse practitioner, Loma Linda Children's Hospital. LA - eng PT - Journal Article PL - United States TA - Crit Care Nurse JT - Critical care nurse JID - 8207799 SB - IM EIN - Crit Care Nurse. 2026 Jun 1;46(3):5. doi: 10.4037/ccn2026213. PMID: 42219211 MH - Humans MH - *Health Literacy/statistics & numerical data/standards MH - *Patient Discharge/standards MH - Female MH - Male MH - Adult MH - *Quality Improvement MH - *Caregivers/education MH - Middle Aged MH - Child MH - *Critical Care Nursing/standards MH - *Patient Education as Topic MH - Infant MH - Child, Preschool MH - Patient Readmission/statistics & numerical data EDAT- 2026/04/01 00:28 MHDA- 2026/04/01 00:29 CRDT- 2026/03/31 20:12 PHST- 2026/04/01 00:29 [medline] PHST- 2026/04/01 00:28 [pubmed] PHST- 2026/03/31 20:12 [entrez] AID - 33000 [pii] AID - 10.4037/ccn2026298 [doi] PST - ppublish SO - Crit Care Nurse. 2026 Apr 1;46(2):47-53. doi: 10.4037/ccn2026298. PMID- 41916414 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1502-7724 (Electronic) IS - 0281-3432 (Print) IS - 0281-3432 (Linking) VI - 44 IP - 1 DP - 2026 Dec TI - Screening for iron deficiency in young women: the predictive validity of a five-item screening instrument (IRON-5). PG - 2649329 LID - 10.1080/02813432.2026.2649329 [doi] LID - 2649329 AB - BACKGROUND: Iron deficiency is the most common micronutrient deficiency worldwide, negatively affecting quality of life and health. Young women are at particularly high risk due to increased iron demands during growth, menstrual blood losses, and dietary habits. There are no official guidelines recommending screening for iron deficiency in healthy young women. This study aimed to develop a screening instrument (IRON-5) to predict iron deficiency in this group, with relevance for use in primary care and school health services. METHODS: In 2023, a cross-sectional study was conducted to assess the prevalence of iron deficiency and associated factors in high school girls. A questionnaire assessing dietary habits, menstrual bleeding patterns, iron supplement use, and hormonal contraceptive use was administered. Iron deficiency was defined as serum ferritin <15 microg/L. A post-hoc analysis identified the strongest predictors of iron deficiency and incorporated them into a risk-scoring model. RESULTS: The final instrument included five predictors: a non-omnivorous diet, heavy menstruation causing discomfort, avoidance of activities due to menstruation, no iron supplementation, and non-use of hormonal contraceptives. A scoring system (0-5) was developed. Using a threshold score of >/= 3, the model achieved a sensitivity of 74% and specificity of 57% for detecting iron deficiency. CONCLUSION: The IRON-5 is a concise and user-friendly screening instrument designed to identify young women at risk of iron deficiency. It demonstrated good sensitivity and may serve as a cost-effective method to prioritize individuals for blood testing. IRON-5 could support identification and prevention strategies in school-based and primary care settings. FAU - Vinge, Fredrik AU - Vinge F AUID- ORCID: 0009-0007-9498-1573 AD - Centre for Primary Health Care Research, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden. AD - University Clinic Primary Care, Skane University Hospital, Region Skane, Sweden. FAU - Stubbendorff, Anna AU - Stubbendorff A AUID- ORCID: 0000-0001-9851-6213 AD - Nutritional Epidemiology, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden. FAU - Bolmsjo, Beata Borgstrom AU - Bolmsjo BB AUID- ORCID: 0000-0001-7655-0613 AD - Centre for Primary Health Care Research, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden. AD - University Clinic Primary Care, Skane University Hospital, Region Skane, Sweden. FAU - Jakobsson, Ulf AU - Jakobsson U AUID- ORCID: 0000-0003-3676-307X AD - Centre for Primary Health Care Research, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden. AD - University Clinic Primary Care, Skane University Hospital, Region Skane, Sweden. FAU - Milos Nymberg, Veronica AU - Milos Nymberg V AUID- ORCID: 0000-0002-3836-3048 AD - Centre for Primary Health Care Research, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden. AD - University Clinic Primary Care, Skane University Hospital, Region Skane, Sweden. FAU - Wolff, Moa AU - Wolff M AUID- ORCID: 0000-0002-0656-7628 AD - Centre for Primary Health Care Research, Department of Clinical Sciences Malmo, Lund University, Malmo, Sweden. AD - University Clinic Primary Care, Skane University Hospital, Region Skane, Sweden. LA - eng PT - Journal Article DEP - 20260331 PL - United States TA - Scand J Prim Health Care JT - Scandinavian journal of primary health care JID - 8510679 RN - 9007-73-2 (Ferritins) RN - E1UOL152H7 (Iron) SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Adolescent MH - *Anemia, Iron-Deficiency/diagnosis/epidemiology MH - Surveys and Questionnaires MH - *Mass Screening/methods MH - Ferritins/blood MH - Prevalence MH - *Iron Deficiencies MH - Menstruation MH - Dietary Supplements MH - Sensitivity and Specificity MH - Feeding Behavior MH - Primary Health Care MH - Iron MH - Diet PMC - PMC13047845 OTO - NOTNLM OT - Iron deficiency OT - adolescent OT - dietary habits OT - female OT - mass screening OT - primary health care OT - risk assessment COIS- No potential conflict of interest was reported by the author(s). EDAT- 2026/04/01 00:28 MHDA- 2026/04/01 00:29 PMCR- 2026/03/31 CRDT- 2026/03/31 19:13 PHST- 2026/04/01 00:29 [medline] PHST- 2026/04/01 00:28 [pubmed] PHST- 2026/03/31 19:13 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - 2649329 [pii] AID - 10.1080/02813432.2026.2649329 [doi] PST - ppublish SO - Scand J Prim Health Care. 2026 Dec;44(1):2649329. doi: 10.1080/02813432.2026.2649329. Epub 2026 Mar 31. PMID- 41915661 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 3 DP - 2026 TI - Validity and reliability of Indonesian version of the digital screen exposure questionnaire (DSEQ) for young children. PG - e0346133 LID - 10.1371/journal.pone.0346133 [doi] LID - e0346133 AB - Studies have shown that excessive screen time in early childhood can negatively affect development. Therefore, assessing screen exposure in young children is important for preventing these negative effects. However, only a limited number of validated and reliable tools have been adapted into the Indonesian language. This study aimed to translate, culturally adapt, and evaluate the validity and reliability of the Digital Screen Exposure Questionnaire (DSEQ) for Indonesian children aged 2-5 years. This cross-sectional study included 171 caregivers. The translation and adaptation processes followed internationally accepted guidelines for patient-reported outcomes measures, with content and face validity evaluated through expert reviews. Reliability was assessed based on the COSMIN guidelines and previous studies, with internal consistency measured using Cronbach's alpha and test-retest reliability assessed in a subsample of 31 caregivers using the intraclass correlation coefficient (ICC). This study is the first cultural adaptation of the DSEQ in Indonesia and demonstrates good face and content validity, as confirmed by expert evaluations. Internal consistency (Cronbach's alpha) was strong for screen-time exposure and home media environment (0.704), media-related behaviors (0.863), and physical activity (0.768), whereas test-retest reliability across the three domains was moderate to high (ICC values: 0.514-0.946), with lower ICC values observed for the item related to parental supervision while watching television, which may vary owing to differences in household routines and parental availability. These findings support the Indonesian DSEQ as a valid and reliable tool for evaluating exposure to digital screens among children. CI - Copyright: (c) 2026 Khatimah et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Khatimah, Nur Faidar Khusnul AU - Khatimah NFK AUID- ORCID: 0009-0006-4838-0200 AD - Department of Physical Therapy, Graduate School of Human Health Science, Tokyo Metropolitan University, Arakawa, Tokyo, Japan. FAU - Jusriani, Jusriani AU - Jusriani J AD - Keanna Center, Optimum Child Growth and Development Center, Makassar, South Sulawesi, Indonesia. FAU - Wulandari, Desi AU - Wulandari D AD - OrthoTrimedical Care Center, Orthotic-Prosthetic and Child Development Therapy Center, Makassar, South Sulawesi, Indonesia. FAU - Gima, Hirotaka AU - Gima H AUID- ORCID: 0009-0007-0630-8400 AD - Department of Physical Therapy, Graduate School of Human Health Science, Tokyo Metropolitan University, Arakawa, Tokyo, Japan. LA - eng PT - Journal Article PT - Validation Study DEP - 20260331 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Indonesia MH - Child, Preschool MH - Surveys and Questionnaires MH - Female MH - Reproducibility of Results MH - Male MH - Cross-Sectional Studies MH - *Screen Time MH - Media Exposure MH - Digital Media PMC - PMC13037967 COIS- The authors have declared that no competing interests exist. EDAT- 2026/03/31 18:49 MHDA- 2026/03/31 18:50 PMCR- 2026/03/31 CRDT- 2026/03/31 13:33 PHST- 2025/11/19 00:00 [received] PHST- 2026/03/15 00:00 [accepted] PHST- 2026/03/31 18:50 [medline] PHST- 2026/03/31 18:49 [pubmed] PHST- 2026/03/31 13:33 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - PONE-D-25-62221 [pii] AID - 10.1371/journal.pone.0346133 [doi] PST - epublish SO - PLoS One. 2026 Mar 31;21(3):e0346133. doi: 10.1371/journal.pone.0346133. eCollection 2026. PMID- 41915137 OWN - NLM STAT- MEDLINE DCOM- 20260629 LR - 20260702 IS - 0974-7559 (Electronic) IS - 0019-6061 (Linking) VI - 63 IP - 7 DP - 2026 Jul TI - Development and Validation of Obesity Interpreter: A Mobile Application-Based Tool for Children and Adolescents. PG - 474-479 LID - 10.1007/s13312-026-00312-9 [doi] AB - OBJECTIVE: To develop and validate Obesity Interpreter, a mobile application tool to assist in assessing children with obesity and avoid unwarranted workup in physiological obesity. METHODS: The Obesity Interpreter offers guidance on probable diagnoses and workup based on clinical inputs. The validation involved comparing the guidance from the Obesity Interpreter, a pediatric endocrinologist, a pediatrician, and a trainee on the final diagnosis (gold standard) in 400 children and adolescents with obesity concerns (270 constitutional, 23 genetic/syndromic, 11 drug-induced, 13 endocrine, 83 normal or overweight). RESULTS: The concordance scores were higher for the endocrinologist (92.1%) and the Obesity Interpreter (99.5%) compared to the pediatrician (75.4%) and the trainee (56.6%). The workup guidance of the Obesity Interpreter aligned with the gold standard in 398 (99.5%) subjects (Cohen's kappa 0.989, 95% CI 0.971, 1.0). Diagnostic workup discrepancies were noted in 83 (20.8%) subjects by the pediatrician and in 162 (40.5%) subjects by the trainee. Utilizing the mobile application would have prevented 288/ 292 (98.6%) errors observed in the study with high agreement for classification recommendation (Cohen's kappa 0.990, 95% CI 0.975, 1.0). CONCLUSION: Obesity Interpreter provided guidance aligned with the gold standard for evaluation of children with obesity. CI - (c) 2026. The Author(s), under exclusive licence to Indian Academy of Pediatrics. FAU - Raithatha, Dhvani AU - Raithatha D AD - Department of Pediatric Endocrinology, Regency Healthcare, A2 Sarvodaya Nagar, Kanpur, Uttar Pradesh, India. FAU - Bajpai, Anurag AU - Bajpai A AUID- ORCID: 0000-0002-3701-2780 AD - Department of Pediatric Endocrinology, Regency Healthcare, A2 Sarvodaya Nagar, Kanpur, Uttar Pradesh, India. dranurag.bajpai@gmail.com. FAU - Narayanan, R AU - Narayanan R AD - Department of Pediatric Endocrinology, Regency Healthcare, A2 Sarvodaya Nagar, Kanpur, Uttar Pradesh, India. FAU - Mahapatra, Alapan AU - Mahapatra A AD - Department of Pediatric Endocrinology, Regency Healthcare, A2 Sarvodaya Nagar, Kanpur, Uttar Pradesh, India. FAU - Yadav, Vibha AU - Yadav V AD - Department of Pediatric Endocrinology, Regency Healthcare, A2 Sarvodaya Nagar, Kanpur, Uttar Pradesh, India. FAU - Joshi, Prachi AU - Joshi P AD - Department of Pediatrics, King George Medical University, Lucknow, Uttar Pradesh, India. FAU - Zehra, Alia AU - Zehra A AD - Department of Pediatrics, King George Medical University, Lucknow, Uttar Pradesh, India. FAU - Bhriguvanshi, Arpita AU - Bhriguvanshi A AD - Department of Pediatrics, King George Medical University, Lucknow, Uttar Pradesh, India. LA - eng PT - Journal Article PT - Validation Study DEP - 20260331 PL - India TA - Indian Pediatr JT - Indian pediatrics JID - 2985062R SB - IM MH - Humans MH - Child MH - Adolescent MH - *Mobile Applications MH - *Pediatric Obesity/diagnosis MH - Female MH - Male MH - Medical Interpreting OTO - NOTNLM OT - Body mass index OT - Childhood obesity OT - Metabolic dysfunction-associated steatotic liver disease OT - Metabolic syndrome OT - Pathological obesity OT - Prevention COIS- Conflict of interest: AB is one of the Directors of MedEClasses, a start-up involved in medical education, and has 60% of the non-listed company holdings. The Obesity Interpreter is part of the MedEClasses Endocrinology Mobile Application. Ethics Approval: This study was approved by the Institutional Ethics Committee, Regency Healthcare, Kanpur; Ref. No. IEC Number RHL-lEC-16060 dated January 07, 2022. EDAT- 2026/03/31 12:33 MHDA- 2026/06/30 00:31 CRDT- 2026/03/31 11:07 PHST- 2025/07/18 00:00 [received] PHST- 2026/03/05 00:00 [accepted] PHST- 2026/06/30 00:31 [medline] PHST- 2026/03/31 12:33 [pubmed] PHST- 2026/03/31 11:07 [entrez] AID - 10.1007/s13312-026-00312-9 [pii] AID - 10.1007/s13312-026-00312-9 [doi] PST - ppublish SO - Indian Pediatr. 2026 Jul;63(7):474-479. doi: 10.1007/s13312-026-00312-9. Epub 2026 Mar 31. PMID- 41914331 OWN - NLM STAT- MEDLINE DCOM- 20260824 LR - 20260824 IS - 1941-0921 (Electronic) IS - 1941-7381 (Print) IS - 1941-0921 (Linking) VI - 18 IP - 5 DP - 2026 Sep-Oct TI - Sport-Specific Outcome Measures Improve Clinical Assessment of Shoulder Injury in Swimmers: A Cohort Study of Specific PROMs. PG - 960-968 LID - 10.1177/19417381261431350 [doi] LID - 19417381261431350 AB - BACKGROUND: Swimming is among the most widely practiced sports globally. Up to 70% of swimmers report shoulder pain that impairs performance. Patient-reported outcome measures (PROMs) are effective, objective tools for assessing such injuries. The aim of this study was to develop and validate swimming-specific adaptations of established shoulder PROMs (ASES-swim and SSV-swim) and compare their psychometric properties and discriminatory ability with generic existing instruments. HYPOTHESIS: Swimming-specific PROMs may more accurately assess shoulder condition in swimmers and monitor recovery, thereby enabling improved evaluation of health status and, ultimately, athletic performance. STUDY DESIGN: Cohort study. METHODS: A total of 167 athletes registered with the Portuguese Swimming Federation (FPN) during the 2023-2024 season were enrolled. Participants were stratified into asymptomatic group (AG = 92) and injured group (IG = 75). Monthly assessments included training characteristics, injury status, and responses to ASES, SSV, SSV-sport, and newly developed ASES-swim and SSV-swim questionnaires over 6 months. RESULTS: SSV-swim correlated strongly with SSV and SSV-sport (r = 0.769, P < 0.001 and r = 0.857, P < 0.001, respectively). ASES-swim scores were highly correlated with ASES scores (r = 0.994, P < 0.001). Both SSV-swim and ASES-swim demonstrated higher internal consistency than the nonadapted PROMs (Cronbach alpha = 0.849 and 0.870, respectively). SSV, SSV-sport, and SSV-swim showed moderate discriminatory ability (area under the curve [AUC] = 0.760, 0.809, and 0.851, respectively), whereas ASES and ASES-swim showed excellent discriminatory ability for detecting injury (AUC = 0.967 and 0.970, respectively). CONCLUSION: ASES-swim and SSV-swim are a valid, reliable, and easy to administer tool for the assessment of shoulder injury and recovery in swimmers. Swimming-specific PROMs provide clinically meaningful improvements in shoulder injury assessment accuracy. CLINICAL RELEVANCE: Swimming-specific PROMs provide clinicians with a sensitive and reliable method for assessing shoulder injury in swimmers, enabling more accurate diagnosis and individualized rehabilitation. Further research should investigate sports-specific PROM adaptations to optimize athlete care across disciplines. FAU - Sousa, Diogo Nunes AU - Sousa DN AUID- ORCID: 0009-0003-3719-5569 AD - Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. AD - ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimaraes, Portugal. FAU - Velho, Tiago AU - Velho T AUID- ORCID: 0009-0004-8529-9263 AD - Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. AD - ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimaraes, Portugal. FAU - Escaleira, Rui AU - Escaleira R AUID- ORCID: 0009-0005-0047-8631 AD - Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. AD - ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimaraes, Portugal. AD - Surgery Department, ULSAM Alto Ave, Viana do Castelo, Portugal. AD - Portuguese Swimming Federation. FAU - Moedas, Daniel AU - Moedas D AUID- ORCID: 0009-0007-2228-746X AD - Portuguese Swimming Federation. FAU - Campos, Barbara AU - Campos B AUID- ORCID: 0000-0001-9415-020X AD - Shoulder and Elbow Unit, Orthopaedics Department, Hospital CUF Tejo, Lisboa, Portugal. FAU - Medeiros-Filho, Joao Felipe AU - Medeiros-Filho JF AUID- ORCID: 0000-0002-4745-4566 AD - Universidade Federal do Rio Grande do Norte Natal, RN, Brazil. FAU - Pereira, Helder AU - Pereira H AUID- ORCID: 0000-0003-2220-6766 AD - Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. AD - ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimaraes, Portugal. AD - Orthopaedics Department, ULSAM Povoa de Varzim/Vila do Conde, Povoa de Varzim, Portugal. AD - Ripoll y De Prado Sports Clinic: Murcia-Madrid FIFA Medical Centre of Excellence, Madrid, Spain. FAU - Malavolta, Eduardo AU - Malavolta E AUID- ORCID: 0000-0003-1956-6445 AD - Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, SP, Brazil. AD - HCOR, Sao Paulo, SP, Brazil. FAU - Sevivas, Nuno AU - Sevivas N AUID- ORCID: 0000-0002-6573-0368 AD - Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. AD - ICVS/3Bs - PT Government Associate Laboratory, Braga/Guimaraes, Portugal. AD - Shoulder and Elbow Unit, Orthopaedics Department, ULSAM Medio Ave, Famalicao, Portugal. AD - Shoulder and Elbow Unit, Orthopaedics Department, Trofa Saude Hospital Braga Sul, Braga, Portugal. LA - eng PT - Journal Article PT - Validation Study DEP - 20260331 PL - United States TA - Sports Health JT - Sports health JID - 101518422 SB - IM MH - Humans MH - *Swimming/injuries MH - *Patient Reported Outcome Measures MH - *Shoulder Injuries/diagnosis MH - Male MH - Psychometrics MH - Female MH - Adolescent MH - Cohort Studies MH - *Athletic Injuries/diagnosis MH - Young Adult MH - Surveys and Questionnaires PMC - PMC13038485 OTO - NOTNLM OT - patient-reported outcome measures (PROMs) OT - shoulder OT - sports medicine OT - swimming COIS- The authors report no potential conflicts of interest in the development or publication of this article. EDAT- 2026/03/31 12:33 MHDA- 2026/08/24 18:42 PMCR- 2026/03/31 CRDT- 2026/03/31 06:03 PHST- 2026/08/24 18:42 [medline] PHST- 2026/03/31 12:33 [pubmed] PHST- 2026/03/31 06:03 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - 10.1177_19417381261431350 [pii] AID - 10.1177/19417381261431350 [doi] PST - ppublish SO - Sports Health. 2026 Sep-Oct;18(5):960-968. doi: 10.1177/19417381261431350. Epub 2026 Mar 31. PMID- 41914274 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260814 IS - 1099-0496 (Electronic) IS - 1099-0496 (Linking) VI - 61 IP - 4 DP - 2026 Apr TI - Does Addition of Oscillatory Positive Expiratory Pressure (OPEP) Device to a Chest Physiotherapy Program Provide Further Benefits in Children With Bronchiectasis?: A Randomized Trial. PG - e71602 LID - 10.1002/ppul.71602 [doi] AB - BACKGROUND: Airway clearance is major part of care for children with bronchiectasis (BE) and oscillatory positive pressure (OPEP) devices are widely used, yet their added value beyond a multicomponent chest physiotherapy (CPT) program remains unclear and device access often entails out of pocket costs. Aim of this study was to evaluate whether adding an OPEP device to a multicomponent CPT program provides additional benefits in exercise capacity and dynamic ventilatory responses in children with BE. METHODS: A randomized trial involving 42 children with non-cystic fibrosis BE was conducted. Children were allocated to either CPT or CPT + OPEP group. Both groups trained at home twice daily for 8 weeks. 6-min walk test (6MWT) with Spiropalm(R) device, spirometry, quadriceps strength measurement and Leicester Cough Questionnaire (LCQ) were applied at baseline and after training. RESULTS: 6MWT distance, change in inspiratory capacity during exertion (DeltaIC), lowest SpO(2), the time spent with a drop of >/= %4 in SpO(2) [T (dSpO(2) >/= %4)], FVC%, FEV(1)%, PEF%, significantly improved in both groups, with no between-groups difference. Program adherence (%) was significantly higher in CPT + OPEP group (85 +/- 15) compared to CPT group (74 +/- 18) (p < 0.05). CONCLUSION: In children with BE, a multicomponent CPT program improved exercise capacity, dynamic ventilatory responses and spirometry, while adding an OPEP device primarily increased adherence and conferred no additional benefit. The decision to add an OPEP device may be individualized to address engagement or feasibility rather than further clinical benefit. TRIAL REGISTRATION: The study was prospectively registered to ClinicalTrials. gov on September 1, 2021, under the registration number NCT05034900. CI - (c) 2026 Wiley Periodicals LLC. FAU - Zeren, Melih AU - Zeren M AUID- ORCID: 0000-0002-9749-315X AD - Department of Physiotherapy and Rehabilitation, Faculty of Health Sciences, Izmir Bakircay University, Izmir, Turkey. FAU - Barlik, Meral AU - Barlik M AUID- ORCID: 0000-0003-1640-1733 AD - Department of Pediatric Pulmonology, Mersin City Training and Research Hospital, Mersin, Turkey. FAU - Tosun, Beyza Nur Caglar AU - Tosun BNC AD - Department of Physiotherapy and Rehabilitation, Graduate Education Institute, Izmir Bakircay University, Izmir, Turkey. FAU - Demir, Esen AU - Demir E AD - Division of Pediatric Pulmonology, Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey. FAU - Gulen, Figen AU - Gulen F AD - Division of Pediatric Pulmonology, Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey. LA - eng SI - ClinicalTrials.gov/NCT05034900 GR - 22479/Scientific Research Projects Office of Ege University/ PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Pediatr Pulmonol JT - Pediatric pulmonology JID - 8510590 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - *Bronchiectasis/therapy/physiopathology MH - Walk Test MH - Exercise Tolerance MH - Spirometry MH - *Positive-Pressure Respiration/instrumentation/methods MH - Adolescent MH - *Physical Therapy Modalities MH - Treatment Outcome OTO - NOTNLM OT - airway clearance OT - bronchiectasis OT - chest physiotherapy OT - children OT - oscillatory positive expiratory pressure EDAT- 2026/03/31 06:58 MHDA- 2026/03/31 12:33 CRDT- 2026/03/31 05:53 PHST- 2026/02/26 00:00 [revised] PHST- 2025/11/11 00:00 [received] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/03/31 12:33 [medline] PHST- 2026/03/31 06:58 [pubmed] PHST- 2026/03/31 05:53 [entrez] AID - 10.1002/ppul.71602 [doi] PST - ppublish SO - Pediatr Pulmonol. 2026 Apr;61(4):e71602. doi: 10.1002/ppul.71602. PMID- 41914013 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1943-278X (Electronic) IS - 0363-0234 (Print) IS - 0363-0234 (Linking) VI - 56 IP - 2 DP - 2026 Apr TI - Comparing Objective Measures of Sleep Disturbance and Sleep Related Impairments as Proximal Risk Indicators of Suicidal Intent and Non-Suicidal Self-Injury. PG - e70091 LID - 10.1111/sltb.70091 [doi] LID - e70091 AB - BACKGROUND: Non-suicidal self-injury (NSSI) and suicidal ideation (SI) are prevalent public health concerns among college students. Poor sleep quality and its consequences are a risk factor for NSSI and SI in this population. Unfortunately, limited research measures the impact of sleep related impairment (SRI) on NSSI/SI, little research compares the relative criterion validity of objective versus SRI measurement for NSSI/SI, and there is limited research measuring NSSI behaviors as a primary outcome. METHODS: This study examined the relationship between passively captured Consensus Sleep Diary indices (i.e., actigraphy), SRI, SI, and frequency of NSSI in a sample of N = 132 college-students reporting past-month NSSI/SI. Participants wore actigraphy wristbands during the 28-day daily ambulatory phase and completed self-report assessments each day (k = 3726 observations). RESULTS: Multilevel mixed effects models failed to find significant relationships between actigraphy-derived sleep quality indices, same-day SI and NSSI frequency, and next-day SI and NSSI frequency. Significant relationships between SRI, same-day SI, and same-day NSSI frequency emerged. DISCUSSION: Results suggest worsening SRI may be an important signal of worsening SI and NSSI frequency. Implications for assessment and monitoring of SRI for college students at risk for NSSI and suicide are discussed. CI - (c) 2026 The Author(s). Suicide and Life-Threatening Behavior published by Wiley Periodicals LLC on behalf of American Association of Suicidology. FAU - Oakey-Frost, Nicolas AU - Oakey-Frost N AUID- ORCID: 0000-0001-8365-6045 AD - VA Salt Lake City Healthcare System, Salt Lake City, Utah, USA. FAU - Moscardini, Emma H AU - Moscardini EH AUID- ORCID: 0000-0003-3057-9458 AD - McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA. FAU - Rogers, Megan L AU - Rogers ML AUID- ORCID: 0000-0002-4969-7035 AD - Department of Psychology, Texas State University, San Marcos, Texas, USA. FAU - Muehlenkamp, Jennifer J AU - Muehlenkamp JJ AUID- ORCID: 0000-0003-2653-082X AD - Department of Psychology, University of Wisconsin, Eau Claire, Wisconsin, USA. LA - eng GR - 2R15MH110960/MH/NIMH NIH HHS/United States PT - Comparative Study PT - Journal Article PL - England TA - Suicide Life Threat Behav JT - Suicide & life-threatening behavior JID - 7608054 SB - IM MH - Humans MH - *Self-Injurious Behavior/psychology/diagnosis MH - Female MH - Actigraphy MH - *Suicidal Ideation MH - *Sleep Wake Disorders/psychology/diagnosis MH - Male MH - Young Adult MH - Risk Factors MH - Adolescent MH - Students/psychology MH - Self Report MH - Adult MH - Sleep Quality PMC - PMC13036479 OTO - NOTNLM OT - NSSI OT - actigraphy OT - daily diary OT - passive sensing OT - sleep quality OT - suicidal ideation COIS- The authors declare no conflicts of interest. EDAT- 2026/03/31 06:58 MHDA- 2026/03/31 06:59 PMCR- 2026/03/31 CRDT- 2026/03/31 04:13 PHST- 2026/03/06 00:00 [revised] PHST- 2025/09/13 00:00 [received] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/03/31 06:59 [medline] PHST- 2026/03/31 06:58 [pubmed] PHST- 2026/03/31 04:13 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - SLTB70091 [pii] AID - 10.1111/sltb.70091 [doi] PST - ppublish SO - Suicide Life Threat Behav. 2026 Apr;56(2):e70091. doi: 10.1111/sltb.70091. PMID- 41913779 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260331 LR - 20260813 IS - 2055-2076 (Print) IS - 2055-2076 (Electronic) IS - 2055-2076 (Linking) VI - 12 DP - 2026 Jan-Dec TI - Predicting childhood anaemia in Ghana with explainable machine learning: A national survey analysis. PG - 20552076261437179 LID - 10.1177/20552076261437179 [doi] LID - 20552076261437179 AB - INTRODUCTION: Childhood anaemia remains a major public health problem in Ghana, with marked regional and socioeconomic disparities. Conventional regression may not fully capture complex, non-linear relationships among biological, maternal, and household factors. We used supervised machine learning to predict anaemia among children aged 6-59 months using nationally representative survey data. METHODS: We analysed the 2022 Ghana Demographic and Health Survey, including de facto children aged 6-59 months with valid haemoglobin and complete covariates (weighted N = 3,382). Anaemia was defined as altitude-adjusted haemoglobin <11.0 g/dL. Twenty-one predictors were included. Data were split into training (80%) and testing (20%) sets using stratified sampling. Six models (logistic regression, decision tree, random forest, gradient boosting, support vector machine, and artificial neural network) were tuned via grid search with 10-fold cross-validation. RESULTS: The weighted prevalence of childhood anaemia was 48.95% (n = 1,655). Gradient boosting showed the best overall discrimination (AUC = 0.72; F1 = 68.99%; accuracy = 66.27%). Support vector machine and logistic regression achieved the highest sensitivity (recall = 72.73% and 71.74%). Random forest showed overfitting (100% training accuracy; test accuracy = 65.23%). Decision tree and neural network performed poorly (AUC = 0.57 and 0.63). Key predictors across models and SHAP were child age, malaria status, maternal anaemia, region, and household wealth (with feature rankings varying by algorithm). CONCLUSION: Machine learning models achieved moderate predictive performance for childhood anaemia in Ghana. Gradient boosting provided the strongest discrimination, while support vector machine and logistic regression offered higher sensitivity for screening. However, these sensitivities imply that approximately 28-30% of anaemic children may be missed, which should be considered when applying these models in public health screening. Identified determinants support targeted, malaria-integrated nutrition and maternal-child interventions in high-risk groups. CI - (c) The Author(s) 2026. FAU - Hassan, Yahye Sheikh Abdulle AU - Hassan YSA AUID- ORCID: 0000-0002-2578-3000 AD - Faculty of Medicine and Health Sciences, Jamhuriya University of Science and Technology, Mogadishu, Somalia. RINGGOLD: 472894 FAU - Omar, Mohamed Abdirahim AU - Omar MA AUID- ORCID: 0009-0003-5933-3846 AD - Faculty of Health Science, Salaam University, Mogadishu, Somalia. RINGGOLD: 472903 FAU - Karikari, Julius Kwabena AU - Karikari JK AUID- ORCID: 0009-0000-1859-2620 AD - University Hospital, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. RINGGOLD: 98763 AD - Department of Epidemiology and Biostatistics, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana. RINGGOLD: 98763 FAU - Ali, Abdirasak Sharif AU - Ali AS AUID- ORCID: 0000-0001-5546-5778 AD - Department of Microbiology and Laboratory Sciences, Faculty of Medicine and Health Sciences, SIMAD University, Mogadishu, Somalia. RINGGOLD: 510012 AD - Blood Bank Unit, Banadir Hospital, Mogadishu, Somalia. FAU - Ahmed, Mohamed Mustaf AU - Ahmed MM AUID- ORCID: 0009-0006-5991-4052 AD - Faculty of Medicine and Health Sciences, SIMAD University, Mogadishu, Somalia. RINGGOLD: 510012 LA - eng PT - Journal Article DEP - 20260327 PL - United States TA - Digit Health JT - Digital health JID - 101690863 PMC - PMC13033076 OTO - NOTNLM OT - Ghana OT - SHAP OT - anemia OT - childhood OT - gradient boosting OT - logistic regression OT - machine learning OT - predictive modelling OT - support vector machine COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/03/31 07:00 MHDA- 2026/03/31 07:01 PMCR- 2026/03/27 CRDT- 2026/03/31 03:54 PHST- 2026/01/15 00:00 [received] PHST- 2026/03/04 00:00 [revised] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/03/31 07:01 [medline] PHST- 2026/03/31 07:00 [pubmed] PHST- 2026/03/31 03:54 [entrez] PHST- 2026/03/27 00:00 [pmc-release] AID - 10.1177_20552076261437179 [pii] AID - 10.1177/20552076261437179 [doi] PST - epublish SO - Digit Health. 2026 Mar 27;12:20552076261437179. doi: 10.1177/20552076261437179. eCollection 2026 Jan-Dec. PMID- 41913715 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260714 IS - 1532-2998 (Electronic) IS - 1532-3005 (Linking) VI - 42 IP - 2 DP - 2026 Apr TI - Heart Rate Variability and Perceived Stress in Normal-Weight Female University Students: The Role of Physical Activity Level. PG - e70167 LID - 10.1002/smi.70167 [doi] AB - Chronic stress, common in university students and particularly pronounced in women, negatively impacts health. Heart Rate Variability (HRV), an autonomic balance measure, is influenced by stress, physical activity (PA), and the menstrual cycle. This study examined HRV and perceived stress differences in healthy-weight female university students by PA level. Fifty-two female university students (18-30 years, BMI 18.5-24.9 kg/m(2)) were recruited. To minimise hormonal variability, assessments for naturally menstruating participants were conducted during the early follicular phase, confirmed through a cycle-tracking application and luteinizing hormone (LH) tests. For participants using hormonal contraceptives, measurements were scheduled during the first week of a new contraceptive cycle. PA was assessed (IPAQ-SF) and categorised as low-moderate or vigorous. HRV was recorded using a Polar H10 over three days for reliability (SDNN, LF, HF, LF/HF ratio) were analysed. Perceived stress used the Perceived Stress Questionnaire (PSQ). Group differences and associations were then analysed, controlling for total PA (METs). Forty-two participants completed the study. Vigorous PA was associated with higher SDNN (p = 0.099, d = -0.620) and lower LF (p = 0.045, d = -0.761) versus the low-moderate PA group, indicating more efficient cardiac autonomic modulation. METs significantly influenced SDNN, HF, LF, and pNN50. However, no significant differences were found in LF/HF ratio (p = 0.990) or perceived stress (p = 0.249) between groups, nor were significant correlations observed between PSQ scores and any HRV indices. Higher PA levels correlate with a more favourable autonomic profile (increased parasympathetic activity, reduced sympathetic drive at rest, unaltered LF/HF balance). The lack of association between PA/perceived stress and perceived stress/HRV suggests a potential dissociation between subjective stress perception and objective autonomic activity in this population. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Santiago, Marta Victoria AU - Santiago MV AUID- ORCID: 0009-0004-0767-6377 AD - Faculty of Health Sciences, European University of the Atlantic, Santander, Spain. FAU - Olmedillas, Hugo AU - Olmedillas H AUID- ORCID: 0000-0003-4625-2759 AD - Department of Functional Biology, Campus del Cristo B, University of Oviedo, Oviedo, Spain. AD - Asturian Research Group in Performance, Readaptation, Training and Health (AstuRES), University of Oviedo, Oviedo, Spain. FAU - Sainz, Julen AU - Sainz J AUID- ORCID: 0009-0002-4993-9994 AD - Faculty of Health Sciences, European University of the Atlantic, Santander, Spain. FAU - Bustillo, Mar AU - Bustillo M AUID- ORCID: 0009-0009-9297-2379 AD - Faculty of Health Sciences, European University of the Atlantic, Santander, Spain. FAU - Heres, Miguel AU - Heres M AUID- ORCID: 0000-0001-5410-8453 AD - Faculty of Health Sciences, European University of the Atlantic, Santander, Spain. FAU - Pulgar, Susana AU - Pulgar S AUID- ORCID: 0000-0002-6845-248X AD - Faculty of Health Sciences, European University of the Atlantic, Santander, Spain. LA - eng GR - Ministerio de Ciencia, Innovacion y Universidades/ PT - Journal Article PL - England TA - Stress Health JT - Stress and health : journal of the International Society for the Investigation of Stress JID - 101089166 SB - IM MH - Humans MH - Female MH - *Heart Rate/physiology MH - Young Adult MH - *Subjective Stress MH - Adult MH - *Students/psychology MH - *Exercise/physiology MH - Adolescent MH - Universities MH - *Autonomic Nervous System/physiology MH - Menstrual Cycle/physiology MH - *Stress, Psychological/physiopathology OTO - NOTNLM OT - exercise OT - heart rate variability OT - stress response OT - women OT - young adults EDAT- 2026/03/31 07:00 MHDA- 2026/03/31 07:01 CRDT- 2026/03/31 03:53 PHST- 2026/01/20 00:00 [revised] PHST- 2025/09/04 00:00 [received] PHST- 2026/03/04 00:00 [accepted] PHST- 2026/03/31 07:01 [medline] PHST- 2026/03/31 07:00 [pubmed] PHST- 2026/03/31 03:53 [entrez] AID - 10.1002/smi.70167 [doi] PST - ppublish SO - Stress Health. 2026 Apr;42(2):e70167. doi: 10.1002/smi.70167. PMID- 41913352 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260925 IS - 1552-5732 (Electronic) IS - 0890-3344 (Linking) VI - 42 IP - 3 DP - 2026 Aug TI - Development and Psychometric Evaluation of the Breastfeeding Beliefs Scale: A Methodological Study. PG - 751-768 LID - 10.1177/08903344261426740 [doi] AB - BACKGROUND: Breastfeeding, recognized as the most effective method for infants to receive human milk, also has significant benefits for maternal health. RESEARCH AIM: The study aimed to develop a psychometric evaluation of the Breastfeeding Beliefs Scale, constructed based on the Health Belief Model in Turkiye. METHODS: This methodological study was conducted with 300 pregnant women attending the Gynecology and Obstetrics Outpatient Clinic of a Ministry of Health State Hospital. Data were collected using a personal information form, the Breastfeeding Beliefs Scale, and the Antenatal Breastfeeding Self-Efficacy Scale-Short Form. Content validity was assessed using the Davis technique. Construct validity was examined through exploratory and confirmatory factor analyses using the Kaiser-Meyer-Olkin measure, Bartlett's test of sphericity, principal component analysis, and model fit indices (chi(2)/df, GFI, AGFI, CFI, RMSEA, and SRMR). Internal consistency was evaluated using Cronbach's alpha coefficients and item-total correlations. RESULTS: The Breastfeeding Beliefs Scale (Emzirme Inanclari Olcegi) consists of 40 items across six subdimensions. Cronbach's alpha coefficients ranged from 0.706 to 0.924, indicating acceptable to excellent reliability. All items demonstrated adequate item-total correlations, and confirmatory factor analysis supported the six-factor structure, with all item t-values exceeding 1.96. Lower scores on the Barrier subscale and higher scores on other subscales reflect more positive breastfeeding beliefs. CONCLUSION: The scale can be used with pregnant women in all trimesters and is useful for assessing breastfeeding beliefs. Further studies are recommended to test its applicability in different populations and countries. FAU - Erbil, Nulufer AU - Erbil N AUID- ORCID: 0000-0003-3586-6237 AD - Ordu University, Turkiye. FAU - Emirik, Leyla AU - Emirik L AD - Ordu University, Turkiye. FAU - Guler, Esra AU - Guler E AD - Ordu University, Turkiye. FAU - Geldi, Busra Nur AU - Geldi BN AD - Ordu University, Turkiye. FAU - Citak, Tuba AU - Citak T AUID- ORCID: 0000-0003-4264-4122 AD - Ordu University, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20260330 PL - United States TA - J Hum Lact JT - Journal of human lactation : official journal of International Lactation Consultant Association JID - 8709498 SB - IM MH - Humans MH - Female MH - *Breast Feeding/psychology MH - *Psychometrics/methods/standards/instrumentation MH - Adult MH - Reproducibility of Results MH - Surveys and Questionnaires MH - Pregnancy MH - Turkey MH - *Health Knowledge, Attitudes, Practice MH - Young Adult MH - Factor Analysis, Statistical MH - Self Efficacy OTO - NOTNLM OT - Breastfeeding Beliefs Scale OT - breastfeeding OT - development OT - health belief model OT - measurement tool pregnant women OT - psychometric evaluation OT - validity and reliability COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/03/31 06:58 MHDA- 2026/09/25 11:44 CRDT- 2026/03/31 00:52 PHST- 2026/09/25 11:44 [medline] PHST- 2026/03/31 06:58 [pubmed] PHST- 2026/03/31 00:52 [entrez] AID - 10.1177/08903344261426740 [doi] PST - ppublish SO - J Hum Lact. 2026 Aug;42(3):751-768. doi: 10.1177/08903344261426740. Epub 2026 Mar 30. PMID- 41913168 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1472-6823 (Electronic) IS - 1472-6823 (Linking) VI - 26 IP - 1 DP - 2026 Mar 30 TI - Association between the Chinese visceral adiposity index and thyroid nodule risk: a retrospective analysis of cross-sectional, case-control, and cohort studies. LID - 10.1186/s12902-026-02240-y [doi] LID - 130 AB - BACKGROUND: With the increasing use of ultrasound, the detection rate of thyroid nodules (TNs) has risen markedly in recent years. However, the relationship between obesity and TNs remains controversial. This study aimed to investigate the association between the Chinese visceral adiposity index (CVAI), a novel obesity indicator, and the risk of TNs. METHODS: A multi-design study was conducted among individuals aged 18-80 years who underwent periodic health examinations in Suzhou, China, from 2020 to 2024. The discovery stage comprised cross-sectional and case-control analyses to examine associations between CVAI and TN risk. The validation stage involved a prospective cohort study evaluating the predictive role of CVAI in incident TNs. Multivariable logistic regression and Cox proportional hazards models were applied. RESULTS: The cross-sectional study included 83,757 participants, and the case-control study included 31,035 matched pairs. The median age was 40.59 and 39.28 years, respectively. Each standard deviation increase in CVAI was significantly associated with an increased risk of TN [cross-sectional: odds ratio (OR) = 1.19, 95% confidence interval (95% CI): 1.16-1.22; case-control: OR = 1.24, 95% CI: 1.20-1.27]. The cohort study including 18,110 participants validated the association [hazard ratio (HR) = 1.12, 95% CI: 1.07-1.18]. Restricted cubic spline analyses demonstrated a nonlinear dose-response relationship, with a steep rise in TN risk at higher CVAI levels. Subgroup analyses revealed stronger associations in females, individuals with lower body mass index (BMI), those who engaged in regular exercise, and participants without dyslipidemia. CONCLUSION: Elevated CVAI was significantly associated with an increased risk of TNs. These findings provided new insights for scientific management and prevention of TNs, highlighting the potential value of CVAI in health management. FAU - Tian, Ting AU - Tian T AD - Central Research Laboratory, Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Hospital for Skin Diseases, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, 210042, China. FAU - Han, Renfang AU - Han R AD - Health Management Center, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215008, China. FAU - Zhou, Quan AU - Zhou Q AD - Health Management Center, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215008, China. FAU - Li, Yuanli AU - Li Y AD - Health Management Center, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215008, China. FAU - Wang, Yi AU - Wang Y AD - Health Management Center, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215008, China. FAU - Zeng, Nimei AU - Zeng N AD - Health Management Center, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215008, China. FAU - Xie, Fangfei AU - Xie F AD - Health Management Center, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215008, China. FAU - Wang, Yun AU - Wang Y AD - Health Management Center, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215008, China. FAU - Zhong, Chenyi AU - Zhong C AD - Center for Human Reproduction and Genetics, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215002, China. zhongchenyi0702@163.com. AD - The Affiliated Suzhou Hospital of Nanjing Medical University, No. 26, Daoqian Road, Gusu District, Suzhou, Jiangsu Province, China. zhongchenyi0702@163.com. FAU - Fan, Jingyi AU - Fan J AD - Health Management Center, Suzhou Municipal Hospital, Gusu School, The Affiliated Suzhou Hospital of Nanjing Medical University, Nanjing Medical University, Suzhou, 215008, China. fanjingyi@njmu.edu.cn. AD - The Affiliated Suzhou Hospital of Nanjing Medical University, No. 242, Guangji Road, Gusu District, Suzhou, Jiangsu Province, China. fanjingyi@njmu.edu.cn. LA - eng GR - SYW2024112/Suzhou Applied Basic Research (Medical and Health) Technology Innovation Project/ GR - SYWD2024144/Suzhou Applied Basic Research (Medical and Health) Technology Innovation Project/ GR - BK20220258/Natural Science Foundation of the Jiangsu Provincial Science and Technology/ GR - GSWS2023109/Gusu Health Talent Plan Talent Research Project/ PT - Journal Article DEP - 20260330 PL - England TA - BMC Endocr Disord JT - BMC endocrine disorders JID - 101088676 RN - Chinese people SB - IM MH - Humans MH - Female MH - *Thyroid Nodule/epidemiology/etiology MH - Cross-Sectional Studies MH - Case-Control Studies MH - Adult MH - Middle Aged MH - China/epidemiology MH - Male MH - Retrospective Studies MH - Risk Factors MH - Young Adult MH - *Obesity, Abdominal/complications/epidemiology MH - Adolescent MH - *Intra-Abdominal Fat MH - Aged MH - Follow-Up Studies MH - Prognosis MH - Aged, 80 and over MH - Body Mass Index MH - East Asian People PMC - PMC13154479 OTO - NOTNLM OT - Intra-abdominal fat OT - Physical examination OT - Risk factors OT - Thyroid nodule COIS- Declarations. Ethics approval and consent to participate: All research was conducted in accordance with both the Declarations of Helsinki and Istanbul. The Periodic Health Examination project was approved by the Ethics Committee of the Affiliated Suzhou Hospital of Nanjing Medical University (Ethical Approval Number: K-2022-105-K01). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/31 06:59 MHDA- 2026/06/28 00:36 PMCR- 2026/03/30 CRDT- 2026/03/31 00:09 PHST- 2025/12/01 00:00 [received] PHST- 2026/03/18 00:00 [accepted] PHST- 2026/06/28 00:36 [medline] PHST- 2026/03/31 06:59 [pubmed] PHST- 2026/03/31 00:09 [entrez] PHST- 2026/03/30 00:00 [pmc-release] AID - 10.1186/s12902-026-02240-y [pii] AID - 2240 [pii] AID - 10.1186/s12902-026-02240-y [doi] PST - epublish SO - BMC Endocr Disord. 2026 Mar 30;26(1):130. doi: 10.1186/s12902-026-02240-y. PMID- 41912617 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 30 TI - Acute physical activity supports inhibitory control in primary school children: a randomised cross-over trial. LID - 10.1038/s41598-026-44375-x [doi] LID - 10647 AB - Studies have found inconsistent results regarding the acute effects of physical activity on inhibitory control in children. More naturalistic studies that have real-world validity and use objective measures of physical activity are essential. This study investigated the acute effects of a pre-existing school-based group physical activity session on inhibitory control. Fifty-five primary school children (9 +/- 1 years old, 40% female) participated in a pre-existing school-based group physical activity session and a sedentary poster-making control condition, both lasting approximately 30 min, in a randomised, cross-over manner. Cognitive tasks were completed before and after both conditions, and measures of performance on these tasks were used as dependent variables in all analyses. Time engaged in moderate-to-vigorous physical activity during each condition was measured by accelerometry and used as a manipulation check. After physical activity there were faster reaction times (beta = -176, 95%CI: -296.43, -59.51) and more commission errors (beta = 1.06, 95%CI: 0.18, 1.95) in the simple reaction time task, but fewer commission errors (beta = -4.64, 95%CI: -9.00 -0.28) in the inhibition task compared to the control condition. Using the same statistical approach, a supplementary analysis was run on a reduced sample of 32 (9 +/- 1 years old, 44% female) whose adherence to conditions was confirmed by accelerometry. Results showed faster reaction times (beta = -205, 95%CI: -384.58, -33.37) in the simple reaction time task and fewer commission errors (beta = -6.10, 95%CI: -11.75, -0.45) in the inhibition task following physical activity. This suggests that an acute bout of physical activity facilitates inhibitory control in primary school children. Optimal effects are seen when participants achieved higher intensity physical activity during the intervention. FAU - Watson, Evelyn AU - Watson E AD - Institute of Sport Exercise and Health, Faculty of Medical Sciences, University College London, London, UK. evelyn.watson.22@ucl.ac.uk. AD - Institute of Cognitive Neuroscience, Faculty of Brain Sciences, University College London, London, UK. evelyn.watson.22@ucl.ac.uk. FAU - Burgess, Paul W AU - Burgess PW AD - Institute of Cognitive Neuroscience, Faculty of Brain Sciences, University College London, London, UK. FAU - Metcalf, Isabel AU - Metcalf I AD - Institute of Sport Exercise and Health, Faculty of Medical Sciences, University College London, London, UK. FAU - Hamer, Mark AU - Hamer M AD - Institute of Sport Exercise and Health, Faculty of Medical Sciences, University College London, London, UK. FAU - Ronca, Flaminia AU - Ronca F AD - Institute of Sport Exercise and Health, Faculty of Medical Sciences, University College London, London, UK. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260330 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Child MH - *Exercise/physiology MH - Cross-Over Studies MH - Schools MH - Male MH - Reaction Time/physiology MH - Accelerometry MH - Cognition/physiology MH - *Inhibition, Psychological PMC - PMC13039183 COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/03/31 00:53 MHDA- 2026/06/28 16:09 PMCR- 2026/03/30 CRDT- 2026/03/30 23:20 PHST- 2025/02/10 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/06/28 16:09 [medline] PHST- 2026/03/31 00:53 [pubmed] PHST- 2026/03/30 23:20 [entrez] PHST- 2026/03/30 00:00 [pmc-release] AID - 10.1038/s41598-026-44375-x [pii] AID - 44375 [pii] AID - 10.1038/s41598-026-44375-x [doi] PST - epublish SO - Sci Rep. 2026 Mar 30;16(1):10647. doi: 10.1038/s41598-026-44375-x. PMID- 41912277 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1557-0681 (Electronic) IS - 1478-2189 (Print) IS - 1478-2189 (Linking) VI - 24 IP - 2 DP - 2026 Jun TI - Activity-Based Functional Exercise for Disability in Systemic Sclerosis: Protocol for a Feasibility Randomised Controlled Trial. PG - e70217 LID - 10.1002/msc.70217 [doi] LID - e70217 AB - INTRODUCTION: Systemic Sclerosis (SSc) is associated with substantial disability in affected patients. Although exercise interventions for SSc have been developed, most focus on isolated body segments rather than global disability. Thus, this study aims to assess the feasibility of a functional activity-based exercise programme designed to address disability in individuals with SSc. METHODS: This feasibility study protocol is designed as a randomised controlled mixed-methods trial. It will include individuals with SSc aged 18-65 years and with a score >/= 1 on the Scleroderma Health Assessment Questionnaire (SHAQ). Participants will be randomly allocated to either a control group, receiving an educational booklet on the disease, or an intervention group receiving the booklet plus a 10-week supervised functional exercise protocol (twice weekly). Feasibility outcomes include recruitment and retention rates, adherence, safety, and adverse events. Preliminary clinical outcomes will address disability level, physical function, fatigue, resilience, symptoms of anxiety and depression, and perceived change. Quantitative data will be analysed using descriptive and inferential statistics, while qualitative data will undergo thematic content analysis. ETHICAL APPROVAL: The study was approved by the Institutional Ethics Committee (Approval Number: 6.992.710). RESULTS: The study is in its initial phase. The reference clinic has 219 registered patients, of whom 183 (83.6%) are preliminarily eligible. Recruitment and subsequent feasibility results are ongoing. CONCLUSION: This protocol proposes an innovative and low-cost approach, whose results will support refinements for a more rigorous clinical trial, despite potential logistical and disease-related limitations. CI - (c) 2026 The Author(s). Musculoskeletal Care published by John Wiley & Sons Ltd. FAU - da Silva Santos, Gabriela AU - da Silva Santos G AUID- ORCID: 0000-0001-5798-3376 AD - Department of Physical Therapy, Federal University of Pernambuco, Recife, Brazil. FAU - Soares, Andre Nunes AU - Soares AN AD - Department of Physical Therapy, Federal University of Pernambuco, Recife, Brazil. FAU - Porto Soares, Geisielly Maria AU - Porto Soares GM AD - Department of Physical Therapy, Federal University of Pernambuco, Recife, Brazil. FAU - Medeiros de Lima, Thais Ariadne AU - Medeiros de Lima TA AD - Department of Physical Therapy, Federal University of Pernambuco, Recife, Brazil. FAU - Fernandes, Juliana AU - Fernandes J AD - Department of Physical Therapy, Federal University of Pernambuco, Recife, Brazil. FAU - Branco Pinto Duarte, Angela Luzia AU - Branco Pinto Duarte AL AD - Department of Clinical Medicine, Federal University of Pernambuco, Recife, Brazil. FAU - da Silva Tenorio, Angelica AU - da Silva Tenorio A AD - Department of Physical Therapy, Federal University of Pernambuco, Recife, Brazil. FAU - Dantas, Andrea Tavares AU - Dantas AT AUID- ORCID: 0000-0003-2345-3363 AD - Department of Clinical Medicine, Federal University of Pernambuco, Recife, Brazil. LA - eng SI - ReBec/RBR-10nbcsbw GR - 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ PT - Clinical Trial Protocol PT - Journal Article PL - England TA - Musculoskeletal Care JT - Musculoskeletal care JID - 101181344 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Disability Evaluation MH - *Exercise Therapy/methods MH - Feasibility Studies MH - *Scleroderma, Systemic/rehabilitation/therapy/physiopathology MH - Randomized Controlled Trials as Topic PMC - PMC13035445 OTO - NOTNLM OT - exercise OT - feasibility studies OT - functional status OT - physical therapy OT - quality of life OT - systemic sclerosis COIS- The authors declare no conflicts of interest. EDAT- 2026/03/31 00:53 MHDA- 2026/03/31 00:54 PMCR- 2026/03/31 CRDT- 2026/03/30 21:02 PHST- 2026/03/13 00:00 [revised] PHST- 2025/09/16 00:00 [received] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/03/31 00:54 [medline] PHST- 2026/03/31 00:53 [pubmed] PHST- 2026/03/30 21:02 [entrez] PHST- 2026/03/31 00:00 [pmc-release] AID - MSC70217 [pii] AID - 10.1002/msc.70217 [doi] PST - ppublish SO - Musculoskeletal Care. 2026 Jun;24(2):e70217. doi: 10.1002/msc.70217. PMID- 41911587 OWN - NLM STAT- Publisher LR - 20260330 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) DP - 2026 Mar 30 TI - The Effects of Adenoidectomy on Children's Eating Patterns, Sleep, and Weight Gain: A Case-Control Study. LID - 10.1097/SCS.0000000000012689 [doi] AB - OBJECTIVE: The purpose of this study is to determine whether children who undergo adenoidectomy show statistically significant improvements in their eating habits, sleep quality, and weight gain. METHODS: Fifty individuals who had undergone adenoidectomy and 50 healthy controls matched for age and sex were included in the case-control study. The Eating Improvement Score, Sleep Quality Score, and Weight Gain Rate were assessed using standardized anthropometric measurements and validated parent-reported scales. RESULTS: Patients who underwent adenoidectomy had considerably higher rates of weight gain (0.74 versus 0.28 kg/mo), Eating Improvement Scores (7.7 versus 4.4), and Sleep Quality Scores (7.8 versus 4.5). CONCLUSION: Nutritional and functional outcomes are significantly improved after adenoidectomy in children with adenoid hypertrophy, demonstrating that the procedure has benefits beyond clear airways. CI - Copyright (c) 2026 by Mutaz B. Habal, MD. FAU - Arslanoglu, Ahmet AU - Arslanoglu A AD - ENT Specialist, Private Practice, Istanbul. FAU - Yazir, Mustafa AU - Yazir M AD - Yazir Private Otorhinolaryngology Clinic, Izmir. FAU - Yagci, Tarik AU - Yagci T AD - Department of Otorhinolaryngology, Medical Faculty, Bilecik Seyh Edebali University, Bilecik. FAU - Bariskan, Serkan AU - Bariskan S AD - ENT Specialist, Private Practice, Istanbul. FAU - Topan, Yunus E AU - Topan YE AD - Department of Otorhinolaryngology, Medical Faculty, Usak University, Usak, Turkiye. LA - eng PT - Journal Article DEP - 20260330 PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 SB - IM OTO - NOTNLM OT - Adenoidectomy OT - The Eating Improvement Score OT - sleep quality score OT - weight gain rate COIS- The authors report no conflicts of interest. EDAT- 2026/03/30 18:30 MHDA- 2026/03/30 18:30 CRDT- 2026/03/30 17:23 PHST- 2026/02/10 00:00 [received] PHST- 2026/03/01 00:00 [accepted] PHST- 2026/03/30 18:30 [medline] PHST- 2026/03/30 18:30 [pubmed] PHST- 2026/03/30 17:23 [entrez] AID - 00001665-990000000-03908 [pii] AID - 10.1097/SCS.0000000000012689 [doi] PST - aheadofprint SO - J Craniofac Surg. 2026 Mar 30. doi: 10.1097/SCS.0000000000012689. PMID- 41910786 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260921 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 4 DP - 2026 Mar 30 TI - Validation of an enhanced pediatric vitamin D deficiency score incorporating sun exposure timing and BMI z-score: analysis in a combined cohort of children. LID - 10.1007/s00431-026-06890-x [doi] LID - 226 AB - Early identification of vitamin D (VitD) deficiency in childhood is essential to support timely prevention and intervention strategies. Building on the previously validated pediatric EVIDENCe-Q questionnaire, this study aimed to refine the tool by integrating two patient-specific weighted variables, sun exposure during peak UVB hours, and BMI z-score categories, both recognized determinants of circulating 25-hydroxyvitamin D (25-OH-D) levels. A total of 354 children (190F/164 M) completed a 20-item pediatric VitD risk questionnaire. Serum 25-OH-D concentrations were available for 280 participants. Three scoring algorithms were evaluated: the unweighted standard model, the sun-weighted model, and the sun + BMI-weighted model. Statistical analyses included ANOVA, Pearson correlations, and receiver operating characteristic (ROC) analyses across biochemical thresholds of vitamin D deficiency and insufficiency (< 10, < 20, and < 30 ng/mL). Vitamin D deficiency (< 10 ng/mL) was observed in 6.8% of participants, while insufficiency affected 38.1% (< 20 ng/mL) and 74.7% (< 30 ng/mL). The unweighted standard model did not discriminate among vitamin D categories (p = 0.622). In contrast, both weighted models showed significant discrimination (sun-weighted: p = 0.036; sun + BMI-weighted: p = 0.030). Only the sun + BMI-weighted model was significantly correlated with serum 25-OH-D levels (r = - 0.13; p = 0.023). ROC analyses demonstrated limited accuracy for the unweighted model, whereas the weighted models showed moderate discriminatory ability, with the Sun + BMI-Weighted Model providing the strongest overall performance. CONCLUSIONS: Incorporating weighted patient-specific variables improves the discriminatory capacity of the pediatric EVIDENCe-Q. Despite moderate accuracy, particularly at lower thresholds, the refined questionnaire, especially the sun + BMI-weighted version, represents a practical, noninvasive screening tool to identify children at risk of hypovitaminosis D. WHAT IS KNOWN: * Vitamin D deficiency is highly prevalent in children worldwide, even in sun-rich regions, and is influenced by factors such as sun exposure and adiposity. * Serum 25-OH-D measurement is the diagnostic gold standard, while questionnaire-based tools offer a non-invasive but currently less accurate alternative in pediatrics. WHAT IS NEW: * Incorporating weighted factors for peak UVB sun exposure and BMI z-score signifi cantly improves the predictive performance of the pediatric EVIDENCe-Q. * The Sun + BMI-weighted model shows a significant correlation with serum 25-OH-D and enhances identification of children at risk of hypovitaminosis D (30 ng/mL). CI - (c) 2026. The Author(s). FAU - Calcaterra, Valeria AU - Calcaterra V AD - Department of Internal Medicine and Therapeutics, University of Pavia, 27100, Pavia, Italy. valeria.calcaterra@unipv.it. AD - Pediatric Department, Buzzi Children's Hospital, 20154, Milan, Italy. valeria.calcaterra@unipv.it. FAU - Cena, Hellas AU - Cena H AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100, Pavia, Italy. hellas.cena@unipv.it. AD - Clinical Nutrition Unit, ICS Maugeri IRCCS, 27100, Pavia, Italy. hellas.cena@unipv.it. FAU - Biino, Ginevra AU - Biino G AD - Institute of Molecular Genetics, National Research Council of Italy, 27100, Pavia, Italy. FAU - Scavone, Ilaria Anna Maria AU - Scavone IAM AD - Pediatric Department, Buzzi Children's Hospital, 20154, Milan, Italy. FAU - Vincenti, Alessandra AU - Vincenti A AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100, Pavia, Italy. FAU - Zuccotti, Gianvincenzo AU - Zuccotti G AD - Pediatric Department, Buzzi Children's Hospital, 20154, Milan, Italy. AD - Department of Biomedical and Clinical Science, University of Milano, 20157, Milan, Italy. LA - eng GR - Project 101128946/PODiaCar-EU4H-2022-PJ-3 co-funded by European Union./ GR - CUP F13C22001210007/National Recovery and resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3-Call for proposal No. 341 of 15 March 2022 of Italian Ministry of University and Research funded by the European Union-NextGenerationEU/ PT - Journal Article PT - Validation Study DEP - 20260330 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Humans MH - *Vitamin D Deficiency/diagnosis/blood/epidemiology MH - Female MH - Male MH - Child MH - *Body Mass Index MH - *Sunlight MH - *Vitamin D/blood/analogs & derivatives MH - Surveys and Questionnaires MH - Child, Preschool MH - ROC Curve MH - Adolescent MH - Algorithms PMC - PMC13035619 OTO - NOTNLM OT - BMI z-score OT - Children OT - Pediatrics OT - Questionnaire OT - Sun exposure timing OT - Vitamin D deficiency COIS- Declarations. Ethics approval: The protocol received approval from the Institutional Review Board of the hospital (Ethics Committee Milano Area 1; Study Registration 2020/ST/234; Protocol No. 0030785). The study was conducted in full accordance with the ethical principles of the Declaration of Helsinki and with current Italian regulations on biomedical research involving minors. Consent to participate: Before participation, written informed consent was obtained from all parents or legal guardians after providing a comprehensive explanation of the study's purpose, procedures, potential risks, and expected benefits. When appropriate, assent was also obtained from older children and adolescents. Confidentiality and data protection were ensured by anonymizing all clinical and questionnaire data prior to analysis. Competing interests: The authors declare no competing interests. EDAT- 2026/03/30 12:50 MHDA- 2026/03/30 12:51 PMCR- 2026/03/30 CRDT- 2026/03/30 11:14 PHST- 2025/12/22 00:00 [received] PHST- 2026/03/21 00:00 [accepted] PHST- 2026/03/11 00:00 [revised] PHST- 2026/03/30 12:51 [medline] PHST- 2026/03/30 12:50 [pubmed] PHST- 2026/03/30 11:14 [entrez] PHST- 2026/03/30 00:00 [pmc-release] AID - 10.1007/s00431-026-06890-x [pii] AID - 6890 [pii] AID - 10.1007/s00431-026-06890-x [doi] PST - epublish SO - Eur J Pediatr. 2026 Mar 30;185(4):226. doi: 10.1007/s00431-026-06890-x. PMID- 41910783 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260918 IS - 1435-1102 (Electronic) IS - 1434-1816 (Linking) VI - 29 IP - 2 DP - 2026 Mar 30 TI - Interpretable prediction of anxiety symptoms during pregnancy via machine learning and SHAP. LID - 59 [pii] LID - 10.1007/s00737-026-01691-5 [doi] AB - PURPOSE: Perinatal anxiety severely impacts maternal and infant health, yet efficient screening remains a challenge. This study aims to create a clinically interpretable screening framework by employing a machine learning (ML) model explained via Shapley additive explanations (SHAP). METHODS: This cross-sectional study was conducted between November 2022 and August 2023 at a tertiary teaching hospital in Guangzhou, China. We assessed pregnant women for prenatal anxiety symptoms via the Generalized Anxiety Disorder Scale (GAD-7). Four ML models-random forest (RF), support vector machine (SVM), extreme gradient boosting (XGBoost), and k-nearest neighbor (KNN)-were trained and evaluated via 10-fold cross-validation with a 7:3 train‒test split. Model performance was assessed by the area under the receiver operating characteristic curve (AUC), and SHAP values were used to interpret feature contributions. RESULTS: We screened 3141 participants via the GAD-7 and identified 318 with prenatal anxiety symptoms, yielding an incidence of 10.1%. The variables most strongly associated with anxiety were selected from 30 candidate variables by using the Boruta algorithm. XGBoost achieved the highest discriminative performance (AUC = 0.712), slightly outperforming RF (AUC = 0.711) and SVM (AUC = 0.633). The KNN model showed near-random performance (AUC = 0.509). SHAP analysis identified sleep quality, premenstrual tension, age, personality, spousal and mother‑daughter‑in‑law relationship quality, occupation, education, dietary habits, and stressful life events as key factors associated with antenatal anxiety symptoms. CONCLUSIONS: The XGBoost model demonstrated acceptable accuracy for identifying antenatal anxiety symptoms. SHAP-based interpretability helps highlight high-impact psychosocial and lifestyle factors, offering a potential tool for early identification and prevention strategies in obstetric care. FAU - Xu, Yao AU - Xu Y AD - Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China. AD - Center for Reproductive Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China. FAU - Nie, Qingwen AU - Nie Q AD - Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China. FAU - Lin, Yanshan AU - Lin Y AD - Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China. AD - Center for Reproductive Medicine, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China. FAU - Xiao, Yanxuan AU - Xiao Y AD - School of Nursing, Southern Medical University, Guangzhou, 510515, China. FAU - Liu, Fang AU - Liu F AD - Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, China. FAU - Ouyang, Xiaoqin AU - Ouyang X AD - Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, China. FAU - Liu, Shuang AU - Liu S AD - Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, China. FAU - Yang, Huiming AU - Yang H AD - Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, China. FAU - Li, Chengcheng AU - Li C AD - Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, China. FAU - Xiao, Chaoqun AU - Xiao C AD - Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, 510515, Guangzhou, China. 183151542@qq.com. FAU - Wang, Zhijian AU - Wang Z AD - Department of Obstetrics and Gynecology, Guangdong Provincial Key Laboratory of Major Obstetric Diseases; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology; Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine; The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510150, China. wzjnfyy@163.com. LA - eng GR - 20261A010097/Guangzhou Health Science and Technology General Guidance Program/ GR - 06-445-1196/High-Level Talent Fund of Guangzhou Medical University/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260330 PL - Austria TA - Arch Womens Ment Health JT - Archives of women's mental health JID - 9815663 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Adult MH - Cross-Sectional Studies MH - *Anxiety/diagnosis/epidemiology/psychology MH - *Machine Learning MH - Boosting Machine Learning Algorithms MH - China/epidemiology MH - *Pregnancy Complications/diagnosis/psychology MH - Predictive Learning Models MH - Random Forest MH - Support Vector Machine MH - Classification Algorithms MH - *Pregnant People/psychology MH - Generalized Anxiety Disorder MH - Prediction Algorithms OTO - NOTNLM OT - Machine learning OT - Prenatal anxiety symptoms OT - SHAP value OT - Screening model COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of the hospital (NFEC-2022-456). Informed consent was obtained from all individual participants included in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/03/30 12:48 MHDA- 2026/06/28 06:35 CRDT- 2026/03/30 11:14 PHST- 2025/12/04 00:00 [received] PHST- 2026/03/08 00:00 [accepted] PHST- 2026/06/28 06:35 [medline] PHST- 2026/03/30 12:48 [pubmed] PHST- 2026/03/30 11:14 [entrez] AID - 10.1007/s00737-026-01691-5 [pii] AID - 10.1007/s00737-026-01691-5 [doi] PST - epublish SO - Arch Womens Ment Health. 2026 Mar 30;29(2):59. doi: 10.1007/s00737-026-01691-5. PMID- 41910540 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1558-9110 (Electronic) IS - 1058-0360 (Print) IS - 1058-0360 (Linking) VI - 35 IP - 3 DP - 2026 May 5 TI - Concurrent Use of Videofluoroscopic and Nutritional Intake Measures in the Assessment of Pediatric Patients With Dysphagia: A Scoping Review. PG - 1360-1379 LID - 10.1044/2026_AJSLP-25-00462 [doi] AB - INTRODUCTION: The videofluoroscopic swallowing study (VFSS) is a radiographic procedure that assesses swallowing physiology in real time by visualizing bolus flow in coordination with structural movement throughout the upper aerodigestive tract. Nutritional intake measures are intended to identify restrictions placed on a patient's method of nutritional intake. There is a lack of rigorous evidence to inform recommendations about appropriate and adequate means of nutritional intake. The purpose of this scoping review was to explore the type and validity of nutritional intake measures and how they are used with VFSS findings to inform nutritional intake recommendations by speech-language pathologists in children (birth to 17 years of age) with dysphagia. METHOD: A comprehensive search of the literature was completed in accordance with the Joanna Briggs Institute methodological recommendations and the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews reporting guidelines. Relevant electronic databases and gray literature were searched without any date restrictions. Reviewers were blinded via Rayyan software. Data were extracted using a data extraction tool created by the research team. RESULTS: Twenty articles met inclusion and exclusion criteria and were included for review. Articles included were from eight different countries, published between the years 2010 and 2024, and included a variety of patient populations and objectives. VFSS administration and nutritional intake measure usage were variable, with fluctuating levels of validity. DISCUSSION: At present, there is no one nutritional intake measure that is consistently administered to all pediatric populations jointly with VFSS administration. The current investigation only looked at nutritional intake measures used jointly with VFSS. Other nutritional intake measures exist and are worth exploring as potential assessment options in clinical practice. CONCLUSION: There is an evident need for the development of nutritional intake measures with strong validity and reliability that consider physiologic impairments observed during VFSS to inform clinical recommendations. FAU - Kiemel, Zoe AU - Kiemel Z AUID- ORCID: 0009-0002-2252-8335 AD - Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL. FAU - Kruse, Jason AU - Kruse J AD - Northwestern University Library, Northwestern University, Evanston, IL. FAU - Smith, Rebecca AU - Smith R AD - Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL. FAU - McGhee, Heather AU - McGhee H AD - Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL. AD - Department of Speech-Language Pathology, Medical University of South Carolina, Charleston. FAU - Adams, Steven M AU - Adams SM AD - Northwestern University Library, Northwestern University, Evanston, IL. FAU - Wintermute, Paige AU - Wintermute P AD - Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL. FAU - Daul, Kendal AU - Daul K AD - Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL. FAU - Bekas, Stephanie AU - Bekas S AD - Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL. FAU - van den Berg, Nadia AU - van den Berg N AD - Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL. FAU - Martin-Harris, Bonnie AU - Martin-Harris B AUID- ORCID: 0000-0001-7840-3764 AD - Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL. AD - Department of Faculty Affairs, School of Communication, Northwestern University, Evanston, IL. AD - Departments of Otolaryngology-Head & Neck Surgery and Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260327 PL - United States TA - Am J Speech Lang Pathol JT - American journal of speech-language pathology JID - 9114726 SB - IM MH - Humans MH - *Deglutition Disorders/physiopathology/diagnostic imaging/diagnosis MH - Child MH - Infant MH - Fluoroscopy/methods MH - Child, Preschool MH - *Deglutition/physiology MH - Adolescent MH - Reproducibility of Results MH - *Nutrition Assessment MH - Video Recording MH - Infant, Newborn MH - Speech-Language Pathology/methods PMC - PMC13151574 EDAT- 2026/03/30 12:49 MHDA- 2026/05/05 18:32 PMCR- 2026/03/27 CRDT- 2026/03/30 10:33 PHST- 2026/05/05 18:32 [medline] PHST- 2026/03/30 12:49 [pubmed] PHST- 2026/03/30 10:33 [entrez] PHST- 2026/03/27 00:00 [pmc-release] AID - 23814764000300140072 [pii] AID - 10.1044/2026_AJSLP-25-00462 [doi] PST - ppublish SO - Am J Speech Lang Pathol. 2026 May 5;35(3):1360-1379. doi: 10.1044/2026_AJSLP-25-00462. Epub 2026 Mar 27. PMID- 41910226 OWN - NLM STAT- MEDLINE DCOM- 20260721 LR - 20260727 IS - 1469-0756 (Electronic) IS - 0032-5473 (Linking) VI - 102 IP - 1210 DP - 2026 Jul 21 TI - One-year epidemiological analysis of patients admitted to a hospital in northern Syria due to burn injuries. PG - 747-753 LID - 10.1093/postmj/qgag038 [doi] AB - BACKGROUND: Burn injuries are among the leading causes of trauma-related morbidity and mortality, particularly in low-resource and conflict-affected regions. This study aimed to evaluate the demographic and clinical factors associated with short-term outcomes among burn patients treated in a war zone hospital in Northern Syria. METHODS: This retrospective observational study included patients hospitalized for burn injuries between 15 April 2023 and 15 April 2024 at Cobanbey Hospital Burn Center. Demographic data, burn etiology, total body surface area (TBSA), burn degree, and clinical outcomes were extracted. Patients with incomplete records were excluded. Univariate and multivariate logistic regression analyses were performed to identify mortality predictors. Receiver Operating Characteristic (ROC) analysis was used to determine the predictive value of TBSA for mortality. RESULTS: A total of 522 patients were analyzed; 57.9% were male, and 53.3% were children under 10 years. Scald burns (53.6%) and second-degree burns (56.1%) were most common. Mortality was significantly associated with older age, chemical burns, TBSA >30%, third-degree burns, multi-region involvement, and intensive care unit admission. Multivariate analysis identified age, TBSA, and multi-zone burns as independent predictors of mortality. ROC analysis showed high predictive value of TBSA for mortality (area under the curve [AUC]: 0.941, P < .001). CONCLUSION: Age, burn severity, and extent (TBSA) are major predictors of mortality in burn patients, particularly in conflict-affected regions. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Fellowship of Postgraduate Medicine. FAU - Gurbuz, Huseyin AU - Gurbuz H AUID- ORCID: 0000-0002-4684-9363 AD - Harran University Faculty of Medicine, Department of Emergency of Medicine, Sanliurfa 63300, Turkiye. FAU - Yaman, Mahmut AU - Yaman M AUID- ORCID: 0000-0002-0783-1419 AD - Dicle University Faculty of Medicine, Department of Emergency of Medicine, Diyarbakir 21280, Turkiye. FAU - Guvelioglu, Ali Muhsin AU - Guvelioglu AM AUID- ORCID: 0009-0000-8180-6425 AD - Prof. Dr. Alaeddin Yavasca State Hospital, Department of Emergency Medicine, Kilis 79000, Turkiye. FAU - Kurt, Bekir Baris AU - Kurt BB AUID- ORCID: 0009-0002-8045-5875 AD - Dr. Ersin Arslan Training and Research Hospital, Department of Emergency Medicine, Gaziantep 27010, Turkiye. FAU - Buyukaslan, Hasan AU - Buyukaslan H AUID- ORCID: 0000-0002-4714-7347 AD - Harran University Faculty of Medicine, Department of Emergency of Medicine, Sanliurfa 63300, Turkiye. LA - eng PT - Journal Article PT - Observational Study PL - England TA - Postgrad Med J JT - Postgraduate medical journal JID - 0234135 SB - IM MH - Humans MH - *Burns/epidemiology/mortality MH - Syria/epidemiology MH - Male MH - Female MH - Retrospective Studies MH - Child MH - Child, Preschool MH - Adult MH - Adolescent MH - Body Surface Area MH - *Hospitalization/statistics & numerical data MH - Infant MH - Middle Aged MH - ROC Curve MH - Burn Units MH - Young Adult OTO - NOTNLM OT - burn OT - epidemiology OT - mortality OT - northern Syria OT - war injuries EDAT- 2026/03/30 12:48 MHDA- 2026/07/21 12:35 CRDT- 2026/03/30 08:44 PHST- 2025/04/25 00:00 [received] PHST- 2026/01/29 00:00 [revised] PHST- 2026/02/19 00:00 [accepted] PHST- 2026/07/21 12:35 [medline] PHST- 2026/03/30 12:48 [pubmed] PHST- 2026/03/30 08:44 [entrez] AID - 8559494 [pii] AID - 10.1093/postmj/qgag038 [doi] PST - ppublish SO - Postgrad Med J. 2026 Jul 21;102(1210):747-753. doi: 10.1093/postmj/qgag038. PMID- 41909647 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 17 DP - 2026 TI - The multidimensional roles and mechanisms of exercise intervention in pediatric oncology. PG - 1784767 LID - 10.3389/fimmu.2026.1784767 [doi] LID - 1784767 AB - The importance of exercise interventions in pediatric oncology is steadily increasing. Their value lies not only in alleviating treatment-related adverse effects but also in supporting physiological recovery, psychological adjustment, and improvements in cognitive function. As research continues to reveal the effects of exercise on the tumor microenvironment, immune modulation, and energy metabolism, its role in pediatric cancer care is expanding from a rehabilitative adjunct to a comprehensive intervention with potential therapeutic relevance. Exercise can enhance tumor-related biological processes by improving blood flow and tissue oxygenation, increasing immune cell activity, mitigating immunosuppression, and modulating glucose utilization and fatty acid metabolism, thereby influencing the energy supply to tumor cells. At the clinical level, exercise strengthens skeletal muscle, improves cardiopulmonary function, increases physical reserves, and reduces long-term side effects such as fatigue and frailty. It also contributes to emotional stability, strengthens self-efficacy, and ameliorates cognitive impairments including attention and memory deficits. Moreover, exercise may exert synergistic effects with chemotherapy, radiotherapy, and immunotherapy by improving treatment tolerance and amplifying overall therapeutic benefit. Despite its potential, the implementation of exercise interventions remains challenged by limited resources, variability in adherence, and age-related differences. Future research should aim to develop personalized exercise prescription systems tailored to pediatric needs, supported by interdisciplinary teams and intelligent monitoring tools to enhance feasibility and scientific rigor. With continued advances in basic research and the accumulation of clinical evidence, exercise is expected to play an increasingly systematic and sustained role in pediatric cancer treatment, providing crucial support for improving rehabilitation quality and long-term health outcomes. CI - Copyright (c) 2026 Dai, Yang, Wu, Wu, Ma, Zhang, Tang, Ye and Du. FAU - Dai, Shengting AU - Dai S AD - School of Sports Science and Engineering, East China University of Science and Technology, Shanghai, China. FAU - Yang, Zhenyu AU - Yang Z AD - School of Sports Science and Engineering, East China University of Science and Technology, Shanghai, China. FAU - Wu, Yang AU - Wu Y AD - School of Sports Science and Engineering, East China University of Science and Technology, Shanghai, China. FAU - Wu, Maoqi AU - Wu M AD - School of Sports Science and Engineering, East China University of Science and Technology, Shanghai, China. FAU - Ma, Murui AU - Ma M AD - School of Sports Science and Engineering, East China University of Science and Technology, Shanghai, China. FAU - Zhang, Xiaonan AU - Zhang X AD - Ningde Normal University, Ningde, Fujian, China. FAU - Tang, Haoyu AU - Tang H AD - School of Sports Science and Engineering, East China University of Science and Technology, Shanghai, China. FAU - Ye, Xinming AU - Ye X AD - School of Sports Science and Engineering, East China University of Science and Technology, Shanghai, China. FAU - Du, Mei AU - Du M AD - School of Sports Science and Engineering, East China University of Science and Technology, Shanghai, China. LA - eng PT - Journal Article PT - Review DEP - 20260313 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 SB - IM MH - Humans MH - *Neoplasms/therapy/rehabilitation/immunology MH - *Exercise Therapy/methods MH - Child MH - Tumor Microenvironment MH - *Exercise MH - Energy Metabolism PMC - PMC13021899 OTO - NOTNLM OT - exercise intervention OT - immune modulation OT - pediatric cancer OT - personalized therapy OT - physiological and psychological recovery OT - tumor microenvironment COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/30 12:50 MHDA- 2026/03/30 12:51 PMCR- 2026/03/13 CRDT- 2026/03/30 06:37 PHST- 2026/01/10 00:00 [received] PHST- 2026/02/13 00:00 [revised] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/03/30 12:51 [medline] PHST- 2026/03/30 12:50 [pubmed] PHST- 2026/03/30 06:37 [entrez] PHST- 2026/03/13 00:00 [pmc-release] AID - 10.3389/fimmu.2026.1784767 [doi] PST - epublish SO - Front Immunol. 2026 Mar 13;17:1784767. doi: 10.3389/fimmu.2026.1784767. eCollection 2026. PMID- 41909584 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260330 LR - 20260813 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Stress, well-being, and optimism in Portuguese youth: how do gender and age shape mental health and eating quality. PG - 1593283 LID - 10.3389/fpsyg.2026.1593283 [doi] LID - 1593283 AB - Stress has been consistently linked to changes in eating behaviors and psychological well-being among adolescents and young adults, yet evidence remains fragmented regarding how gender, developmental stage, and psychological resources jointly shape these outcomes. Grounded in stress-coping models, self-regulation theories, and a life-span developmental perspective, this study examines age- and gender-related differences in stress, well-being, optimism, and eating quality within a post-lockdown context. A cross-sectional study was conducted with 951 Portuguese adolescents and young adults aged 15-26 years. Data were collected across three post-lockdown periods (2020-2022) and aggregated after confirming negligible time-related effects (eta (2) /=0.70) and high emergency activation intention (Emergency Activation Intention Score (EAIS) >/= 20). Data were analyzed using multivariable logistic regression. RESULTS: Adequate awareness was achieved by only 22.9% (n = 618) of the caregivers. Notably, symptom recognition varied substantially: identification rates were relatively high for cyanosis (71.0%) and severe chest indrawing (68.4%), but markedly lower for very low oxygen saturation (36.6%) and apnea (40.7%). Conversely, a majority of the cohort (n = 1,756, 65.0%) demonstrated appropriate emergency activation intentions. Caregivers exhibited a high propensity to contact emergency services during urgent scenarios (86-89%) while exercising suitable restraint during non-urgent presentations (12.3%). Multivariable analysis identified college education as the most robust predictor of adequate awareness (aOR = 3.41, 95% CI: 2.75-4.23, p < 0.001), followed by knowledge of the emergency number 120 (aOR = 1.67, p = 0.004) and a history of prior respiratory hospitalization (aOR = 1.34, p = 0.015). Furthermore, a distinct dose-response relationship regarding health literacy was observed, with adequate awareness being significantly more prevalent among caregivers with high health literacy compared to those with low health literacy (29.8% vs. 15.1%, p < 0.001). Finally, emergency activation rates were influenced by the clinical setting, as caregivers in the emergency department demonstrated significantly higher rates than those in outpatient environments (70.7% vs. 62.8%, p < 0.001). CONCLUSION: Despite appropriate emergency activation intentions, caregivers' limited recognition of red-flag symptoms highlights a critical knowledge-behavior gap. Targeted educational interventions addressing these specific deficits are essential to improving pediatric respiratory emergency outcomes. CI - Copyright (c) 2026 Li and Li. FAU - Li, Ling AU - Li L AD - Pediatric Neurology and Respiratory Medicine, The Central Hospital of Enshi Tujia and MiaoAutonomous Prefecture, Enshi, Hubei, China. FAU - Li, Zhengtao AU - Li Z AD - Pediatric Neurology and Respiratory Medicine, The Central Hospital of Enshi Tujia and MiaoAutonomous Prefecture, Enshi, Hubei, China. LA - eng PT - Journal Article DEP - 20260312 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC13018107 OTO - NOTNLM OT - caregiver knowledge OT - emergency activation intention OT - emergency medical services OT - health literacy OT - pediatric respiratory danger signs COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/30 12:50 MHDA- 2026/03/30 12:51 PMCR- 2026/03/12 CRDT- 2026/03/30 06:17 PHST- 2025/09/10 00:00 [received] PHST- 2026/02/14 00:00 [revised] PHST- 2026/02/16 00:00 [accepted] PHST- 2026/03/30 12:51 [medline] PHST- 2026/03/30 12:50 [pubmed] PHST- 2026/03/30 06:17 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - 10.3389/fmed.2026.1702865 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Mar 12;13:1702865. doi: 10.3389/fmed.2026.1702865. eCollection 2026. PMID- 41906482 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260708 IS - 1469-7599 (Electronic) IS - 0021-9320 (Linking) VI - 58 IP - 3 DP - 2026 May TI - Adverse self-rated health transition among older adults in India: a retrospective life course approach. PG - 193-209 LID - 10.1017/S0021932026100546 [doi] AB - Self-rated health (SRH) is a validated epidemiological measure that captures an individual's overall health perception and predicts morbidity and mortality. Despite extensive research on SRH among older adults in India, evidence on its transition across the life course remains limited. Using data from 70,595 individuals aged 45 years and above from the Longitudinal Aging Study in India (LASI) 2017-2018, this study examined transitions in SRH from childhood to older adulthood. An adverse SRH trajectory was defined as a shift from good childhood health to poor or fair health in later life. Descriptive, bivariate, and multivariable logistic regression analyses were conducted. Overall, 51% of older adults experienced an adverse SRH trajectory. Higher odds were observed among women (AOR: 1.30), individuals with substance consumption (AOR:1.24), chronic multimorbidity (AOR: 3.37), functional limitations (AOR: 2.03), and depression (AOR: 1.51). Early-life disadvantages - child labour, child marriage, and persistent household poverty - were also significant risk factors. In contrast, higher education and participation in social and physical activities were protective. These findings indicate that an adverse subjective health trajectory is shaped by cumulative life-course exposures rather than ageing alone. Strengthening early-life social investments and community-based wellness initiatives is vital to promote healthy and equitable ageing in India. FAU - Rahaman, Margubur AU - Rahaman M AUID- ORCID: 0000-0003-2403-9033 AD - Department of Community and Family Medicine, https://ror.org/04yve5w51All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India. FAU - Venkatesh, U AU - Venkatesh U AUID- ORCID: 0000-0001-8059-9364 AD - Department of Community and Family Medicine, https://ror.org/04yve5w51All India Institute of Medical Sciences, Gorakhpur, Uttar Pradesh, India. FAU - Bera, Om Prakash AU - Bera OP AD - Global Health Advocacy Incubator (GHAI), USA. FAU - Grover, Ashoo AU - Grover A AD - Indian Council of Medical Research, New Delhi, India. LA - eng PT - Journal Article DEP - 20260330 PL - England TA - J Biosoc Sci JT - Journal of biosocial science JID - 0177346 SB - IM MH - Humans MH - India/epidemiology MH - Female MH - Aged MH - Middle Aged MH - Retrospective Studies MH - Male MH - Longitudinal Studies MH - *Health Status MH - *Aging/psychology MH - *Health Transition MH - Socioeconomic Disparities in Health MH - *Self Report MH - Risk Factors MH - *Diagnostic Self Evaluation MH - Aged, 80 and over OTO - NOTNLM OT - India OT - LASI OT - healthy ageing OT - life course OT - subjective health EDAT- 2026/03/30 06:29 MHDA- 2026/07/08 12:57 CRDT- 2026/03/30 02:13 PHST- 2026/07/08 12:57 [medline] PHST- 2026/03/30 06:29 [pubmed] PHST- 2026/03/30 02:13 [entrez] AID - S0021932026100546 [pii] AID - 10.1017/S0021932026100546 [doi] PST - ppublish SO - J Biosoc Sci. 2026 May;58(3):193-209. doi: 10.1017/S0021932026100546. Epub 2026 Mar 30. PMID- 41906166 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Mar 30 TI - Body image dissatisfaction among adolescents residing in Kathmandu Metropolitan City: a community-based cross-sectional study. LID - 10.1186/s40359-026-04457-x [doi] LID - 675 AB - BACKGROUND: Body image dissatisfaction (BID) among adolescents is a growing public health concern globally, linked to unhealthy eating behaviors, low self-esteem, and psychological distress. In Nepal, research on BID remains limited, particularly in exploring both genders and the influence of behavioral, perceptual, and familial factors. This study aimed to assess the prevalence of BID and its associated factors among adolescents in Kathmandu Metropolitan City. METHODS: A community-based cross-sectional study was conducted among 313 adolescents aged 10-19 years. Data were collected between 8th -30th June 2024 using a semi-structured, interviewer-administered questionnaire and anthropometric measurements. The questionnaire covered four domains: socio-demographic, behavioral, perceptual, and anthropometric characteristics. Validated instruments, including Body Shape Questionnaire (BSQ-16B), Figure Rating Scale, and Perceived Beauty Standards Scale (PBSS-8), were utilized. Eight wards were randomly selected, and households were approached through systematic sampling at fixed intervals. Descriptive and inferential statistical analyses were performed, and multivariable binary logistic regression was used to identify factors associated with body image dissatisfaction. Statistical significance was set at p < 0.05. RESULTS: The prevalence of BID was 24.3% (95% CI: 19.8-28.8). Female adolescents were nearly twice as likely as males to report dissatisfaction (AOR = 1.99; 95% CI: 1.02-3.88). Overweight/obese adolescents had significantly higher odds of BID (AOR = 2.41; 95% CI: 1.16-5.02). Adolescents who skipped meals (AOR = 4.14; 95% CI: 2.01-8.52) and those who experienced body shaming (AOR = 2.70; 95% CI: 1.37-5.36) were at increased risk. Perceiving one's body as "a bit too large" (AOR = 3.51; 95% CI: 1.33-9.31) or "much too large" (AOR = 8.68; 95% CI: 2.99-20.14) also showed strong associations with dissatisfaction. CONCLUSION: Nearly one in four adolescents experienced BID, with greater vulnerability among females, those with overweight/obesity, and those exposed to body shaming. These findings suggest the importance of incorporating body image literacy and psychosocial wellbeing components into existing adolescent health and school-based education programs in Nepal. CI - (c) 2026. The Author(s). FAU - Tamrakar, Shaina AU - Tamrakar S AUID- ORCID: 0009-0001-1570-8779 AD - Department of Public Health, CiST College, Pokhara University, Kathmandu, Nepal. FAU - Paudel, Shishir AU - Paudel S AUID- ORCID: 0000-0003-3077-6697 AD - Department of Public Health, CiST College, Pokhara University, Kathmandu, Nepal. AD - National Centre for Epidemiology and Population Health, The Australian National University, Canberra, Australia. FAU - Khatri, Dhurba AU - Khatri D AUID- ORCID: 0000-0001-5244-5536 AD - Kathmandu Institute of Child Health, Hepali Height, Budhanilkantha, Nepal. FAU - Chalise, Anisha AU - Chalise A AUID- ORCID: 0000-0003-1478-454X AD - Center for Research on Environment, Health and Population Activities, Lalitpur, Nepal. anisha.chalise90@gmail.com. LA - eng PT - Journal Article DEP - 20260330 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Female MH - Adolescent MH - Cross-Sectional Studies MH - Male MH - Nepal/epidemiology MH - *Body Dissatisfaction/psychology MH - Child MH - Urban Population/statistics & numerical data MH - Young Adult MH - *Body Image/psychology MH - Body Satisfaction MH - Prevalence PMC - PMC13154522 OTO - NOTNLM OT - Adolescents OT - Beauty standards OT - Body image dissatisfaction OT - Body shaming OT - Figure rating scale OT - Urban Nepal COIS- Declarations. Ethics approval and consent to participate: This study adheres to the ethical principles outlined in Declaration of Helsinki regarding the use of human subjects in research. Ethical approval for this study was obtained from the Institutional Review Committee of CiST College, Pokhara University, Registration no: (16/080/081). The data was collected only after obtaining written informed consent from all the participants. Written informed consent was obtained directly from participants aged 18 years and above prior to their enrollment. For participants younger than 18 years, written informed assent was also obtained from them along with the written informed consent from their parents. To uphold the confidentiality of participant information, identification numbers were assigned instead of using students' names. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/30 00:29 MHDA- 2026/05/09 07:20 PMCR- 2026/03/30 CRDT- 2026/03/29 23:15 PHST- 2025/09/06 00:00 [received] PHST- 2026/03/25 00:00 [accepted] PHST- 2026/05/09 07:20 [medline] PHST- 2026/03/30 00:29 [pubmed] PHST- 2026/03/29 23:15 [entrez] PHST- 2026/03/30 00:00 [pmc-release] AID - 10.1186/s40359-026-04457-x [pii] AID - 4457 [pii] AID - 10.1186/s40359-026-04457-x [doi] PST - epublish SO - BMC Psychol. 2026 Mar 30;14(1):675. doi: 10.1186/s40359-026-04457-x. PMID- 41906155 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Mar 29 TI - Evaluation of the dental and skeletal effects of mandibular advancement by herbst appliance combined with miniscrews: a retrospective study. LID - 10.1186/s12903-026-08222-9 [doi] LID - 805 AB - BACKGROUND: Skeletal Class II malocclusion with mandibular retrognathia is a common, condition that can compromise oral function and facial aesthetics. The Herbst appliance is an effective fixed functional appliance; however, it may result in mesial movement of mandibular molars and proclination of mandibular incisors. Miniscrews may help mitigate these side effects. This study aimed to compare the dental and skeletal effects of conventional Herbst appliances versus Herbst appliances combined with miniscrews in adolescent patients with skeletal Class II malocclusion and mandibular retrognathia. METHODS: This retrospective study included 37 adolescent patients with skeletal Class II malocclusion. The control group (n = 20, 12.58 +/- 1.09 years, 10 males, 10 females) was treated with conventional Herbst appliances, whereas the experimental group (n = 17, 12.52 +/- 0.73 years, 8 males, 9 females) received Herbst appliances combined with miniscrews implanted in the mandibular external oblique ridges. CBCT data were obtained before (T1) and after (T2) treatment, with cephalometric variables measured using Dolphin Imaging software. RESULTS: After treatment, both groups showed increased lower incisor proclination, increased mandibular growth and reduced overjet. The experimental group had significantly less increase in IMPA, greater increases in SNB, Co-Go, Co-Gn, and Pog-SP, and a greater decrease in ANB compared to the control group. CONCLUSIONS: Both control and experimental groups stimulate mandibular growth, but miniscrews provided better anchorage control, resulting in less increase in IMPA, and achieve correction through greater skeletal changes. These results offer preliminary insights for the clinical management of skeletal Class II malocclusion, though further validation through well-designed randomized controlled trials is warranted. FAU - Liao, Jiayi AU - Liao J AD - The Affiliated Stomatological Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. AD - The Key Laboratory of Oral Biomedicine, Nanchang, Jiangxi Province, China. AD - Jiangxi Province Clinical Research Center for Oral Diseases, Nanchang, China. FAU - Fan, Manlin AU - Fan M AD - Department of stomatology, Gaoxin Branch of The First Affiliated Hospital of Nanchang University, Nanchang, China. FAU - Huang, Xiaoxian AU - Huang X AD - The Affiliated Stomatological Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. FAU - Li, Zhihua AU - Li Z AD - The Affiliated Stomatological Hospital, Jiangxi Medical College, Nanchang University, Nanchang, China. lwlq323@163.com. AD - The Key Laboratory of Oral Biomedicine, Nanchang, Jiangxi Province, China. lwlq323@163.com. AD - Jiangxi Province Clinical Research Center for Oral Diseases, Nanchang, China. lwlq323@163.com. LA - eng PT - Journal Article DEP - 20260329 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - Retrospective Studies MH - Female MH - *Malocclusion, Angle Class II/therapy/diagnostic imaging MH - *Orthodontic Appliances, Functional MH - Male MH - *Bone Screws MH - *Mandibular Advancement/instrumentation/methods MH - Child MH - *Retrognathia/therapy MH - *Orthodontic Anchorage Procedures/instrumentation MH - Cephalometry MH - Adolescent MH - Treatment Outcome MH - Incisor PMC - PMC13151183 OTO - NOTNLM OT - Functional Therapy OT - Lower incisor proclination OT - Mandibular retrognathia OT - Skeletal Class II malocclusion COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Institutional Review Board of The Affiliated Stomatological Hospital of Nanchang University (Approval No. NC2024-010). Informed consent was obtained from all participants and their legal guardians prior to inclusion in the study. Consent for publication: Consent forms for publication was obtained from all subjects involved in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/03/30 00:29 MHDA- 2026/06/27 12:36 PMCR- 2026/03/29 CRDT- 2026/03/29 23:15 PHST- 2025/08/16 00:00 [received] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/06/27 12:36 [medline] PHST- 2026/03/30 00:29 [pubmed] PHST- 2026/03/29 23:15 [entrez] PHST- 2026/03/29 00:00 [pmc-release] AID - 10.1186/s12903-026-08222-9 [pii] AID - 8222 [pii] AID - 10.1186/s12903-026-08222-9 [doi] PST - epublish SO - BMC Oral Health. 2026 Mar 29;26(1):805. doi: 10.1186/s12903-026-08222-9. PMID- 41906142 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260509 LR - 20260813 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2026 Mar 30 TI - Validity and reliability of the Pica, ARFID and Rumination Disorder Interview-ARFID Questionnaire (PARDI-AR-Q) in Turkish adolescents. LID - 10.1186/s40337-026-01585-y [doi] LID - 106 AB - PURPOSE: Although global awareness of avoidant/restrictive food intake disorder (ARFID) is increasing, non-Western countries remain underrepresented in the research literature. The Pica, ARFID, and Rumination Disorder Interview-ARFID Questionnaire (PARDI-AR-Q), one of the most extensively validated instruments with strong psychometric properties, is widely used to assess ARFID in both clinical and non-clinical pediatric populations. However, to date, no study has evaluated its reliability and validity among adolescents in Turkey. Therefore, this study aimed to investigate the validity and reliability of the Turkish version of the PARDI-AR-Q in an adolescent sample. METHOD: The sample comprised 483 adolescents aged 12-18 years, Participants completed a sociodemographic and clinical data form, the PARDI-AR-Q, the Nine-Item Avoidant/Restrictive Food Intake Disorder Screen (NIAS), the Food Neophobia Scale (FNS), the Eating Disorder Examination-Questionnaire Short (EDE-QS), and the Revised Child Anxiety and Depression Scale-Child version (RCADS-CV) on an online platform. RESULTS: The mean age of the participants was 15.1 years (SD = 1.9). Of these participants, 170 (35.2%) were male and 313 (64.8%) were female. The PARDI-AR-Q showed good to excellent internal consistency, with a well-fitting four-factor structure, including severity of impact (alpha = 0.955), sensory-based avoidance (alpha = 0.96), concern about aversive consequences (alpha = 0.965), and lack of interest (alpha = 0.848). Test-retest analyses further supported the reliability of the scale. Each PARDI-AR-Q subscale correlated most highly with its conceptually matched NIAS subscale, whereas non-target subscales demonstrated minimal or no associations, supporting both its convergent and discriminant validity. In addition, the PARDI-AR-Q subscales were primarily unrelated to eating attitudes related to weight and shape (EDE-QS), which also provides evidence for its discriminant validity. CONCLUSION: These findings demonstrate that the Turkish version of the PARDI-AR-Q is a reliable and valid instrument for assessing ARFID symptoms in community samples of Turkish adolescents. The Turkish version of the PARDI-AR-Q may contribute to the identification of ARFID-related symptom patterns in adolescents; however, its clinical utility for early detection should be further established through studies conducted in clinical samples using diagnostic interviews. CI - (c) 2026. The Author(s). FAU - Celik, Yusuf Selman AU - Celik YS AD - Department of Child and Adolescent Psychiatry, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Okumus, Hande Gunal AU - Okumus HG AD - Department of Child and Adolescent Psychiatry, Usak Training and Research Hospital, Usak, Turkey. FAU - Oksuzoglu, Makbule Esen AU - Oksuzoglu ME AD - Department of Child and Adolescent Psychiatry, Kastamonu University Faculty of Medicine, Kastamonu, Turkey. FAU - Kasak, Meryem AU - Kasak M AD - Department of Child and Adolescent Psychiatry, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Solgun, Gorkem AU - Solgun G AD - Department of Child and Adolescent Psychiatry, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Bryant-Waugh, Rachel AU - Bryant-Waugh R AD - South London and Maudsley NHS Foundation Trust, London, UK. AD - Institute of Psychiatry, Psychology and Neuroscience, Kings College London, London, UK. FAU - Ogutlu, Hakan AU - Ogutlu H AUID- ORCID: 0000-0002-1325-446X AD - Department of Child and Adolescent Psychiatry, University College Dublin, Dublin, Ireland. hogutlu@gmail.com. AD - Department of Child and Adolescent Psychiatry, Cognitive Behavioral Psychotherapies Association, Karum Is Merkezi Iran Caddesi No: 21 06680 Gaziosmanpasa Mah., 06680, Cankaya, Ankara, Turkiye. hogutlu@gmail.com. LA - eng PT - Journal Article DEP - 20260330 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC13154423 OAB - Avoidant/Restrictive Food Intake Disorder (ARFID) is a eating disorder that can affect individuals across the lifespan, including children, adolescents, and adults, by limiting the amount or variety of food they eat. Early identification is important, yet many countries, including Turkey, lack reliable tools to assess ARFID in young people. The PARDI-AR-Q is a widely used questionnaire that helps identify different reasons why a young person may avoid food, such as sensitivity to taste or texture, fear of choking or vomiting, or a general lack of interest in eating. In this study, we tested the Turkish version of the PARDI-AR-Q in more than 400 adolescents aged 12-18. We wanted to understand whether the questionnaire works well, measures what it is supposed to measure, and gives consistent results over time. Our findings showed that the Turkish PARDI-AR-Q is accurate, reliable, and easy for adolescents to complete. Each part of the questionnaire clearly matched the eating difficulty it was designed to measure, and other problems like anxiety, depression, or concerns about weight and shape did not influence it. Overall, this study shows that the Turkish PARDI-AR-Q is a valuable tool for spotting early signs of ARFID in adolescents. This may help families, teachers, and healthcare professionals support young people who struggle with eating before their problems become more serious. OABL- eng OTO - NOTNLM OT - ARFID OT - Adolescents OT - PARDI-AR-Q OT - Pica OT - Reliability OT - Rumination disorder OT - Validity COIS- Declarations. Ethics approval and consent to participate: The Ethics Committee of Ankara Etlik City Hospital approved the study (January 29, 2024 / No: AESH-BADEK-2025-0068). By the principles of the Declaration of Helsinki, all parents and children were informed about the study, and consent forms were signed. Competing interests: The authors declare no competing interests. EDAT- 2026/03/30 00:29 MHDA- 2026/03/30 00:30 PMCR- 2026/03/30 CRDT- 2026/03/29 23:14 PHST- 2025/11/19 00:00 [received] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/03/30 00:30 [medline] PHST- 2026/03/30 00:29 [pubmed] PHST- 2026/03/29 23:14 [entrez] PHST- 2026/03/30 00:00 [pmc-release] AID - 10.1186/s40337-026-01585-y [pii] AID - 1585 [pii] AID - 10.1186/s40337-026-01585-y [doi] PST - epublish SO - J Eat Disord. 2026 Mar 30;14(1):106. doi: 10.1186/s40337-026-01585-y. PMID- 41906103 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Mar 30 TI - Assessing key mental health-related lifestyle behaviours and experiences in a single scale: a validation of the Personal Experiences in Everyday Life (PEEL) questionnaire. LID - 10.1186/s12887-026-06790-x [doi] LID - 421 AB - BACKGROUND: Adolescence is a period of heightened vulnerability to mental health problems, with lifestyle habits and negative social experiences representing both risk and resilience factors. Existing tools typically assess a limited range of such habits and experiences. The Personal Experiences in Everyday Life (PEEL) questionnaire is a brief measure of key modifiable lifestyle behaviours and negative social experiences. We examined its psychometric properties and associations with symptoms of depression, anxiety, and psychological wellbeing. METHODS: Two community samples, a mid-adolescent (n = 552; mean age = 13.7, SD = 0.5, range 13-14; 48% female) and a late-adolescent sample (n = 383; mean age = 19.0, SD = 1.7, range 16-25; 76% female), were recruited from secondary schools/universities and completed the PEEL, assessing positive (e.g., 'Sport/exercise') and risky (e.g., 'Smoking/vaping) lifestyle behaviours, and negative social experiences (e.g., 'Being bullied'). We examined the PEEL's factor structure, internal consistency, test-retest reliability and the associations with mental health and wellbeing, including moderation by sex and developmental stage. The RCADS-25 and DASS-21 measured depressive and anxiety symptoms; scores were standardised (z-scores) and pooled. RESULTS: A three-factor solution for the PEEL items was supported across both samples: Positive Activities, Unhealthy Diet, and Risky Activities. For conceptual clarity, Risky Activities were divided into Substance Use and Negative Social Experiences, yielding four internally consistent subscales with good test-retest reliability. All factors were significantly associated with depression, anxiety, and wellbeing; Negative Social Experiences showed the strongest associations with depression and anxiety. Stronger positive associations between Substance Use and anxiety were evident in females, and stronger negative associations between Substance Use and Negative Social Experiences with wellbeing were seen in males. Stronger associations between Negative Social Experiences and depression and anxiety occurred in younger adolescents. Unhealthy Diet was positively associated with wellbeing in younger adolescents but negatively associated in older adolescents. CONCLUSIONS: The PEEL is an efficient and valid measure of adolescents' lifestyle behaviours and negative social experiences. Negative social experiences accounted for much of the observed associations with mental health, highlighting the role of social context alongside lifestyle behaviours. The PEEL may support research seeking to understand or modify lifestyle and social drivers of adolescent mental health. FAU - Tang, P AU - Tang P AD - Department of Psychology, School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK. FAU - Kostyrka-Allchorne, K AU - Kostyrka-Allchorne K AD - Department of Psychology, School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK. k.kostyrka-allchorne@qmul.ac.uk. FAU - Murray, A AU - Murray A AD - School of Psychology, University of Edinburgh, Edinburgh, UK. FAU - Stoilova, M AU - Stoilova M AD - Department of Media and Communications, London School of Economics and Political Science, London, UK. FAU - Azeri, E AU - Azeri E AD - Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Livingstone, S AU - Livingstone S AD - Department of Media and Communications, London School of Economics and Political Science, London, UK. FAU - Sonuga-Barke, E AU - Sonuga-Barke E AD - Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. LA - eng GR - National Institute for Health and Care Research (NIHR)/ PT - Journal Article PT - Validation Study DEP - 20260330 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Female MH - Adolescent MH - Male MH - *Life Style MH - Surveys and Questionnaires MH - Reproducibility of Results MH - Psychometrics MH - Young Adult MH - *Mental Health MH - Psychological Well-Being MH - Depression/diagnosis MH - Adult MH - Anxiety/diagnosis PMC - PMC13154467 OTO - NOTNLM OT - Adolescence OT - Anxiety OT - Depression OT - Lifestyle behaviours OT - Negative social experiences OT - Psychometrics OT - Wellbeing COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the World Medical Association Declaration of Helsinki. Ethical approvals were obtained from the London School of Economics and Political Science (reference 249287 and 18934) and Queen Mary University of London (reference PSY2023-39 A). All participants provided written informed consent to participate in the study; informed consent was additionally obtained from parents or legal guardians of participants under the age of 16. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/30 00:29 MHDA- 2026/06/27 12:38 PMCR- 2026/03/30 CRDT- 2026/03/29 23:13 PHST- 2025/11/25 00:00 [received] PHST- 2026/03/23 00:00 [accepted] PHST- 2026/06/27 12:38 [medline] PHST- 2026/03/30 00:29 [pubmed] PHST- 2026/03/29 23:13 [entrez] PHST- 2026/03/30 00:00 [pmc-release] AID - 10.1186/s12887-026-06790-x [pii] AID - 6790 [pii] AID - 10.1186/s12887-026-06790-x [doi] PST - epublish SO - BMC Pediatr. 2026 Mar 30;26(1):421. doi: 10.1186/s12887-026-06790-x. PMID- 41906090 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Mar 30 TI - The role of sonographic estimated fetal weight compared to clinical assessment: superior accuracy only in extreme fetal weight cases. LID - 10.1186/s12884-026-08871-2 [doi] LID - 504 AB - BACKGROUND: Estimated fetal weight (EFW) is of key importance in antenatal care, as inaccuracies can contribute to adverse outcomes and unnecessary interventions. However, both clinical and sonographic methods for EFW have demonstrated limited accuracy, and different factors were found to be associated with increased error range. This study aimed to compare the accuracy of sonographic and clinical EFW methods and identify factors influencing estimation errors. METHODS: This retrospective analysis included singleton pregnancies delivering at >/= 37 weeks of gestational age between 2014 and 2023. Participants with recorded clinical and sonographic EFW within 14 days of delivery were included. Exclusion criteria included multiple gestations, absence of either clinical or sonographic EFW, and incomplete data. EFW accuracy was evaluated against actual neonatal birthweight using overall absolute error and absolute percent error, using paired t-test. Differences in error categories (> 10% and > 20%), specificity, sensitivity, positive predictive value (PPV) and negative predictive value (NPV) were evaluated using McNemar test. Subgroup analyses included normal weight ( (BMI 18.5-24.9), obese patients (BMI >/= 30), tall women (height > 172 cm), nulliparous and multiparous women, and neonates with birth weights >/= 4500 g, 4000-4499 g, and 10% error in each method. RESULTS: Out of 61,531 term deliveries in the study period,14,400 women were included in the study. Sonographic EFW demonstrated significantly higher accuracy among birthweights extremes of /= 4500 g with lower mean absolute percent error in these groups (11.3% vs. 15.0% and 10.6% vs. 12.3%, respectively). Clinical estimation showed a higher negative predictive value for ruling out extreme birthweight (54.9% vs. 44.1%), supporting its usefulness as a first-line screening tool in routine obstetric care. While statistically significant differences were observed in favor of sonographic EFW across other subgroups and the entire study population, no differences of clear clinical relevance were found, as absolute differences were minimal. Low birth weight, macrosomia >/= 4500 g and nulliparity were associated with a high estimation error in both sonographic and clinical EFW, with a greater extent observed in clinical EFW. CONCLUSIONS: Sonographic EFW exhibits superior accuracy in cases of extreme birth weights (/= 4500 g). Among other populations, differences between sonographic and clinical EFW were minimal and of limited clinical relevance. This knowledge should be incorporated into daily practice and decision-making processes to ensure optimal patient care. FAU - Heresco, Lior AU - Heresco L AD - Department of Obstetrics and Gynecology, Meir Medical Center, 59 Tchernichovsky St, Kfar Saba, Israel. lior160@gmail.com. AD - Gray Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. lior160@gmail.com. FAU - Yehuda, Chaya Ben AU - Yehuda CB AD - Clalit Health Services, Tel Aviv, Israel. FAU - Cohen Rappaport, Romi AU - Cohen Rappaport R AD - Gray Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Gluska, Hadar AU - Gluska H AD - Department of Obstetrics and Gynecology, Meir Medical Center, 59 Tchernichovsky St, Kfar Saba, Israel. AD - Gray Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Biron-Shental, Tal AU - Biron-Shental T AD - Department of Obstetrics and Gynecology, Meir Medical Center, 59 Tchernichovsky St, Kfar Saba, Israel. AD - Gray Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Weitzner, Omer AU - Weitzner O AD - Department of Obstetrics and Gynecology, Meir Medical Center, 59 Tchernichovsky St, Kfar Saba, Israel. AD - Gray Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260330 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - *Fetal Weight MH - *Ultrasonography, Prenatal/methods MH - Pregnancy MH - Retrospective Studies MH - Birth Weight MH - Adult MH - Predictive Value of Tests MH - Infant, Newborn MH - Gestational Age MH - Sensitivity and Specificity MH - Fetal Macrosomia PMC - PMC13154497 OTO - NOTNLM OT - Clinical examination OT - Fetal weight estimation OT - Leopold's maneuvers OT - Ultrasound COIS- Declarations. Ethics approval and consent to articipate: The study was approved by the Institutional Review Board of Meir Medical Center (Helsinki approval number 0245-23-MMC, approved on October 6, 2024). The Ethics Committee waived the requirement for informed consent, as the data were retrospective and fully anonymized. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/30 00:29 MHDA- 2026/06/27 22:35 PMCR- 2026/03/30 CRDT- 2026/03/29 23:13 PHST- 2025/11/01 00:00 [received] PHST- 2026/02/23 00:00 [accepted] PHST- 2026/06/27 22:35 [medline] PHST- 2026/03/30 00:29 [pubmed] PHST- 2026/03/29 23:13 [entrez] PHST- 2026/03/30 00:00 [pmc-release] AID - 10.1186/s12884-026-08871-2 [pii] AID - 8871 [pii] AID - 10.1186/s12884-026-08871-2 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Mar 30;26(1):504. doi: 10.1186/s12884-026-08871-2. PMID- 41905845 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260703 IS - 1878-0946 (Electronic) IS - 1744-165X (Linking) VI - 31 IP - 4 DP - 2026 Aug TI - The Golden Hour and beyond: A neuroprotection bundle to reduce intraventricular hemorrhage. PG - 101729 LID - S1744-165X(26)00031-4 [pii] LID - 10.1016/j.siny.2026.101729 [doi] AB - Intraventricular hemorrhage (IVH) remains one of the most consequential complications facing extremely preterm infants, with enduring effects on survival and neurodevelopment. The first 60 min of life (the Golden Hour) offers a uniquely modifiable window to stabilize physiology, smooth cardio-cerebral transition, and implement neuroprotective strategies that may prevent or decrease the risk of IVH. This review synthesizes randomized trials, observational cohorts, and multicenter quality-improvement (QI) initiatives to define a pragmatic, evidence-based approach to Golden Hour care, and extends that approach through the first few days of life with targeted practices in positioning, handling, respiratory management, hemodynamic intervention, nutrition, blood product transfusions, analgesia/sedation, infection mitigation, and family engagement. We emphasize antenatal corticosteroids and maternal magnesium sulfate, delivery at tertiary centers, delayed umbilical cord clamping, meticulous thermoregulation, early use of continuous positive airway pressure and, if intubated, gentle use of ventilation, head-midline with head-of-bed elevation, early yet judicious cardiovascular support, restricted blood sampling, early parenteral nutrition, cautious oxygen targets with limited FiO(2) swings, caffeine therapy, restrictive platelet transfusion thresholds, tight sodium control, and structured nursing rounds with minimal stimulation. Checklists and tables model high-reliability care. While not every component is individually proven to reduce severe IVH, bundled and protocolized adoption has repeatedly improved proximate physiological targets and, in several initiatives, reduced IVH incidence. We propose an integrated, time-phased bundle for the Golden Hour and the following few days of life with implementation checklists. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Qattea, Ibrahim AU - Qattea I AD - Division of Neonatology, Cleveland Clinic Children's, Cleveland, OH, USA; Division of Neonatology, Medical City Arlington, Arlington, TX, USA. FAU - Acun, Ceyda AU - Acun C AD - Division of Neonatology, Cleveland Clinic Children's, Cleveland, OH, USA. FAU - Mohamed, Mohamed A AU - Mohamed MA AD - Division of Neonatology, Cleveland Clinic Children's, Cleveland, OH, USA. FAU - Aly, Hany AU - Aly H AD - Division of Neonatology, Cleveland Clinic Children's, Cleveland, OH, USA; Department of Obstetrics, Gynecology & Reproductive Biology, Cleveland Clinic, Cleveland, OH, USA. Electronic address: alyh@ccf.org. LA - eng PT - Journal Article PT - Review DEP - 20260324 PL - Netherlands TA - Semin Fetal Neonatal Med JT - Seminars in fetal & neonatal medicine JID - 101240003 SB - IM MH - Humans MH - Infant, Newborn MH - *Neuroprotection MH - *Cerebral Intraventricular Hemorrhage/prevention & control MH - Infant, Extremely Premature MH - *Infant, Premature, Diseases/prevention & control OTO - NOTNLM OT - Extremely preterm OT - Golden hour OT - Intraventricular hemorrhage OT - Neonatal intensive care OT - Neuroprotection OT - Quality improvement OT - Stabilization COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/30 00:29 MHDA- 2026/06/28 06:35 CRDT- 2026/03/29 21:56 PHST- 2026/06/28 06:35 [medline] PHST- 2026/03/30 00:29 [pubmed] PHST- 2026/03/29 21:56 [entrez] AID - S1744-165X(26)00031-4 [pii] AID - 10.1016/j.siny.2026.101729 [doi] PST - ppublish SO - Semin Fetal Neonatal Med. 2026 Aug;31(4):101729. doi: 10.1016/j.siny.2026.101729. Epub 2026 Mar 24. PMID- 41905059 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260714 IS - 1573-2509 (Electronic) IS - 0920-9964 (Linking) VI - 293 DP - 2026 Jul TI - The Remote Exercise And Lifestyle (REAL) intervention for first-episode psychosis: feasibility and preliminary effects of online group fitness training. PG - 58-66 LID - S0920-9964(26)00095-2 [pii] LID - 10.1016/j.schres.2026.03.018 [doi] AB - BACKGROUND: Lifestyle interventions, including exercise, can improve physical and mental health outcomes in first-episode psychosis (FEP), but availability of face-to-face programmes is limited. Teleconferencing software (such as Zoom) presents new opportunities for lifestyle interventions, at scale. Thus, this study assessed the feasibility and preliminary impact of remotely delivered, supervised exercise sessions for FEP. METHODS: A single-arm, eight-week feasibility study was conducted in two NHS Early Intervention Services (EIS) for FEP. Participants aged 18-35 years were offered twice-weekly live Zoom sessions, streaming body-weight exercise videos followed by a brief lifestyle discussion facilitated by the research team. Feasibility metrics were recruitment, retention, attendance and adverse events, along with pre-post self-report measures of physical activity, weight, psychological distress, functioning, life satisfaction, and self-efficacy. RESULTS: Of 45 participants approached, 32 (71%) consented, 27/32 (84%) commenced the intervention, and 21/27 (78%) completed the follow-up assessment. Participants attended an average of 7.6 live online exercise sessions (+/-5.1) over their 8 week intervention period. Over 90% of 70 exercise sessions offered had participants in live attendance, with no adverse events. After 8 weeks, significant increases were seen in physical activity (p < 0.01) and psychosocial functioning (p = 0.05). Psychological distress decreased, particularly among those attending >/=50% of sessions (n = 12). No significant changes were observed in other measures. CONCLUSIONS: Twice-weekly online sessions, using pre-existing exercise videos, appears feasible, safe and engaging for young adults with FEP, and potentially beneficial for psychological wellbeing and functioning. Further research is required includes RCTs with an embedded process and economic evaluations, and implementation studies. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - French, Chloe AU - French C AD - Division of Psychology and Mental Health, The University of Manchester, Manchester, M13 9PL, UK; Division of Nursing, Midwifery and Social Work, The University of Manchester, Manchester, UK. FAU - Sawyer, Chelsea AU - Sawyer C AD - Division of Psychology and Mental Health, The University of Manchester, Manchester, M13 9PL, UK. FAU - Fabian, Hannah AU - Fabian H AD - Division of Psychology and Mental Health, The University of Manchester, Manchester, M13 9PL, UK; Psychology, School of Social Sciences, University of Westminster, 115 New Cavendish Street, London, W1W 6UW, UK. FAU - Hassan, Lamiece AU - Hassan L AD - Division of Psychology and Mental Health, The University of Manchester, Manchester, M13 9PL, UK. FAU - Sainsbury, John AU - Sainsbury J AD - Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK. FAU - Scrivano, Luana AU - Scrivano L AD - Division of Psychology and Mental Health, The University of Manchester, Manchester, M13 9PL, UK; Department of Care in Long Term Conditions, Florence Nightingale Faculty of Nursing, Midwifery & Palliative Care, King's College London, London, UK. FAU - Stubbs, Brendon AU - Stubbs B AD - Division of Social Psychiatry, Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria; Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK; Comprehensive Centre for Clinical Neuroscience and Mental Health (C3nmh), Medical University of Vienna, Vienna, Austria. FAU - Bucci, Sandra AU - Bucci S AD - Division of Psychology and Mental Health, The University of Manchester, Manchester, M13 9PL, UK; Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK. FAU - Torous, John AU - Torous J AD - Beth Israel Deaconness Medical Centre, Harvard Medical School, Boston, MA, United States. FAU - Firth, Joseph AU - Firth J AD - Division of Psychology and Mental Health, The University of Manchester, Manchester, M13 9PL, UK; Greater Manchester Mental Health NHS Foundation Trust, Manchester, UK. Electronic address: joseph.firth@manchester.ac.uk. LA - eng PT - Journal Article DEP - 20260328 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM MH - Humans MH - *Psychotic Disorders/rehabilitation/therapy MH - Young Adult MH - Male MH - Female MH - Feasibility Studies MH - Adolescent MH - Adult MH - *Exercise Therapy/methods MH - *Life Style MH - *Exercise MH - Follow-Up Studies OTO - NOTNLM OT - Digital OT - Exercise OT - Lifestyle OT - Online OT - Physical activity OT - Psychosis COIS- Declaration of competing interest JF is supported by a UK Research and Innovation Future Leaders Fellowship (MR/Y033876/1) and the NIHR Manchester Biomedical Research Centre (NIHR203308). The views expressed are those of the author(s) and not necessarily those of the NIHR or the Department of Health and Social Care. JF has provided consultancy, speaking engagements and/or advisory services to Atheneum, Bayer, ParachuteBH Ltd., LLMental, Nestle UK, HedoniaUS and Arthur D Little, independent of this work. SB is supported by a National Institute for Health and Care Research (NIHR) Research Professorship Grant (grant number NIHR 300794) and acknowledges support from the NIHR Manchester Biomedical Research Centre (grant number NIHR203308). The views expressed are those of the authors and not necessarily those of the NIHR or the Department of Health and Social Care. SB is co-inventor and co-founder of CareLoop Health Ltd., a University of Manchester start-up to develop and market digital solutions for mental health problems, currently in schizophrenia and postnatal depression. BS is supported by an NIHR advanced Fellowship BS (NIHR 301206). BS is on the editorial board of Journal of Physical Activity and Health, MENPA, Brazilian Journal of Psychiatry and Ageing Research Reviews. BS has received an honorarium from a co-edited textbook on exercise and mental illness for unrelated work with ASICS and FitXR Ltd. The other authors have no conflicts of interest to declare. EDAT- 2026/03/30 00:29 MHDA- 2026/05/20 00:32 CRDT- 2026/03/29 19:01 PHST- 2025/09/25 00:00 [received] PHST- 2026/02/16 00:00 [revised] PHST- 2026/03/20 00:00 [accepted] PHST- 2026/05/20 00:32 [medline] PHST- 2026/03/30 00:29 [pubmed] PHST- 2026/03/29 19:01 [entrez] AID - S0920-9964(26)00095-2 [pii] AID - 10.1016/j.schres.2026.03.018 [doi] PST - ppublish SO - Schizophr Res. 2026 Jul;293:58-66. doi: 10.1016/j.schres.2026.03.018. Epub 2026 Mar 28. PMID- 41904849 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260714 IS - 1873-376X (Electronic) IS - 1570-0232 (Linking) VI - 1276 DP - 2026 May 15 TI - Development and validation of an LC-MS/MS method for the analysis of total ascorbic acid capacity in plasma. PG - 125023 LID - S1570-0232(26)00112-1 [pii] LID - 10.1016/j.jchromb.2026.125023 [doi] AB - A robust and fast LC-MS/MS method for quantifying total ascorbic acid (vitamin C) in plasma was developed and validated. Ascorbic acid is vital for antioxidant defense and enzymatic processes. Deficiency and hypovitaminosis remain prevalent in specific patient groups and can result in overlooked or misattributed clinical symptoms. To preserve ascorbic acid after venapuncture, EDTA blood samples were kept on ice and processed within two hours. Dehydroascorbic acid was reduced to ascorbic acid using tris(2-carboxyethyl)phosphine (TCEP). Ascorbic acid was separated by reversed-phase chromatography and detected by tandem mass spectrometry in negative ion mode. Method validation followed standard protocols. Retrospective analysis of 547 patient samples, analyzed with this method, was performed to assess the incidence of vitamin C deficiency and hypovitaminosis.A TCEP concentration of 15 mM was sufficient. Ascorbic acid eluted at 1.08 min, with a total runtime of 4.6 min. Intra- and inter-assay imprecision (three concentrations) ranged from 1.8 to 2.2% and 3.2-5.7%, respectively. The limit of quantification was 1.1 mumol/L, suitable for detecting deficiency (<11.4 mumol/L). Among the tested patients, 10% were deficient and 20% had hypovitaminosis. Males had approximately 11 mumol/L lower vitamin C levels than females, independent of age.This validated LC-MS/MS method enables accurate assessment of total ascorbic acid in clinical settings. With a significant proportion of patients showing suboptimal vitamin C levels, increased awareness is needed to support targeted screening and nutritional interventions. CI - Copyright (c) 2024. Published by Elsevier B.V. FAU - Kelly, Dylan AU - Kelly D AD - Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. Electronic address: s.d.kellij@umcg.nl. FAU - van der Ley, Claude P AU - van der Ley CP AD - Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. FAU - Booij, Ron AU - Booij R AD - Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. FAU - Kema, Ido P AU - Kema IP AD - Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. FAU - Vos, Michel J AU - Vos MJ AD - Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. FAU - van Faassen, Martijn AU - van Faassen M AD - Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. LA - eng PT - Journal Article DEP - 20260322 PL - Netherlands TA - J Chromatogr B Analyt Technol Biomed Life Sci JT - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences JID - 101139554 RN - PQ6CK8PD0R (Ascorbic Acid) SB - IM MH - *Ascorbic Acid/blood MH - Humans MH - *Tandem Mass Spectrometry/methods MH - *Liquid Chromatography-Mass Spectrometry/methods MH - Reproducibility of Results MH - Female MH - Male MH - Limit of Detection MH - Linear Models MH - Adult MH - Middle Aged MH - Adolescent MH - Ascorbic Acid Deficiency/blood OTO - NOTNLM OT - Ascorbic acid OT - Chromatography OT - Hypovitaminosis OT - LC-MS/MS OT - Mass spectrometry OT - Plasma OT - TCEP OT - Validation OT - Vitamin C COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/29 18:34 MHDA- 2026/04/19 17:47 CRDT- 2026/03/29 13:01 PHST- 2025/12/11 00:00 [received] PHST- 2026/01/29 00:00 [revised] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/04/19 17:47 [medline] PHST- 2026/03/29 18:34 [pubmed] PHST- 2026/03/29 13:01 [entrez] AID - S1570-0232(26)00112-1 [pii] AID - 10.1016/j.jchromb.2026.125023 [doi] PST - ppublish SO - J Chromatogr B Analyt Technol Biomed Life Sci. 2026 May 15;1276:125023. doi: 10.1016/j.jchromb.2026.125023. Epub 2026 Mar 22. PMID- 41904341 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 28 TI - Basketball participation improves sleep quality through psychological flexibility in adolescents. LID - 10.1038/s41598-026-46073-0 [doi] LID - 10733 AB - This study investigated the relationship between basketball participation and sleep quality among adolescents, focusing on the mediating role of psychological flexibility. The research aimed to clarify how participation in structured team sports contributes to daytime and nighttime aspects of sleep health, including daytime distress and insomnia symptoms. A total of 818 students (54.03% male) from Grades 5 to 9 participated in the study. Participants completed validated questionnaires assessing basketball participation, psychological flexibility, daytime distress, and insomnia symptoms. Reliability and validity analyses confirmed satisfactory psychometric properties for all scales. Multiple regression and structural equation modeling were conducted to examine the direct and indirect associations, and a bias-corrected bootstrapping approach (5,000 resamples) was used to test mediation effects. Basketball participation showed significant negative effects on both daytime distress (beta = - 0.191, 95% CI [-0.265, - 0.113]) and insomnia symptoms (beta = - 0.214, 95% CI [-0.173, - 0.095]). Psychological flexibility exerted significant negative effects on daytime distress (beta = - 0.398) and insomnia symptoms (beta = - 0.402), and it mediated the relationships between basketball participation and both outcomes. The indirect effects were significant for daytime distress (beta = - 0.129, 95% CI [-0.170, - 0.095]) and insomnia symptoms (beta = - 0.130, 95% CI [-0.292, - 0.134]), accounting for 40.31% and 37.79% of the total effects, respectively. Basketball participation was associated with lower levels of daytime distress and insomnia symptoms, both directly and indirectly through enhanced psychological flexibility. The results underscore the role of sport-based engagement in promoting psychological adaptability and sleep health among adolescents. Integrating physical activity with interventions targeting psychological flexibility may represent an effective strategy for improving emotional regulation and sleep quality in youth. FAU - Peng, Bo AU - Peng B AD - School of sports training, Chengdu Sport University, Chengdu, Sichuan, China. 2461556160@qq.com. FAU - Liu, Tong AU - Liu T AD - School of sports training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Ren, Yawei AU - Ren Y AD - School of sports training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Kong, Mingmin AU - Kong M AD - School of sports training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Yin, Zhongen AU - Yin Z AD - College of Physical Education and Health Management, Chongqing University of Education, Nan'an, Chongqing, China. LA - eng GR - 22XTY016/National Social Science Fund of China/ PT - Journal Article DEP - 20260328 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Basketball/psychology/physiology MH - Adolescent MH - Male MH - *Sleep Quality MH - *Sleep Initiation and Maintenance Disorders/psychology MH - Surveys and Questionnaires MH - Female MH - *Sleep/physiology MH - Psychometrics PMC - PMC13039140 OTO - NOTNLM OT - Adolescents OT - Basketball participation OT - Daytime distress OT - Insomnia symptoms OT - Psychological flexibility OT - Sleep quality COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study strictly adhered to the principles outlined in the Declaration of Helsinki and complied with the ethical guidelines issued by relevant national and institutional authorities. The research protocol was formally reviewed and approved by the Ethics Committee of Chengdu Sport University (Approval Number: CTYLL2025004) to ensure compliance with ethical research standards. As the majority of participants in this study were minors, their rights were fully protected throughout the implementation of the research, including but not limited to obtaining consent through their legal guardians when applicable. In special cases, we obtained approval from the Ethics Committee to communicate with parents through class teachers and obtain parental consent in these specific circumstances. The study followed ethical standards to ensure informed consent, and participants' privacy was rigorously safeguarded during data collection and analysis. All procedures were designed to minimize potential risks, while ensuring safety, respect, and confidentiality, effectively protecting the rights and well-being of the participants. EDAT- 2026/03/29 07:35 MHDA- 2026/06/27 12:36 PMCR- 2026/03/28 CRDT- 2026/03/28 23:18 PHST- 2025/11/10 00:00 [received] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/06/27 12:36 [medline] PHST- 2026/03/29 07:35 [pubmed] PHST- 2026/03/28 23:18 [entrez] PHST- 2026/03/28 00:00 [pmc-release] AID - 10.1038/s41598-026-46073-0 [pii] AID - 46073 [pii] AID - 10.1038/s41598-026-46073-0 [doi] PST - epublish SO - Sci Rep. 2026 Mar 28;16(1):10733. doi: 10.1038/s41598-026-46073-0. PMID- 41903777 OWN - NLM STAT- MEDLINE DCOM- 20260610 LR - 20261022 IS - 1876-2867 (Electronic) IS - 1876-2859 (Print) IS - 1876-2859 (Linking) VI - 26 IP - 4 DP - 2026 May-Jun TI - The Feasibility of Using Best Practice Alerts in Pediatric Primary Care for Obesity Research. PG - 103310 LID - S1876-2859(26)00092-6 [pii] LID - 10.1016/j.acap.2026.103310 [doi] AB - OBJECTIVE: Recruiting participants in pediatric obesity research is challenging due to logistical and systemic barriers. This study evaluated the use of a best practice alert (BPA) within the electronic health record (EHR) to aid in recruitment for a randomized controlled trial testing a pediatric obesity treatment intervention. METHODS: The BPA was designed to identify eligible patients aged 5 to 17 years with a body mass index >/=95th percentile during their annual well-child visits. Between January 2018 and March 2020, the BPA was utilized in 4 primary care clinics. Patients were identified in the EHR and pre-screened by the study team. RESULTS: The BPA was deployed to 2121 individual patients, and providers responded to 85% of alerts. Over half (52%) of patients indicated interest in further contact by the study team. The BPA facilitated recruitment 68% (177/261) of participants or 16% of those who agreed to be contacted. CONCLUSIONS: Overall, the BPA was responsible for the majority of total enrollment in the trial. This study demonstrates the potential of BPAs to facilitate recruitment into pediatric obesity treatment studies. CI - Copyright (c) 2026 Academic Pediatric Association. Published by Elsevier Inc. All rights reserved. FAU - Scott, Annika B AU - Scott AB AD - Duke University School of Medicine (AB Scott, N Zucker, and E Schwark), Durham, NC. Electronic address: Annika.kruse@duke.edu. FAU - Armstrong, Sarah AU - Armstrong S AD - Duke Department of Pediatrics (S Armstrong, M Windom, and JS Li), Durham, NC. FAU - Windom, McAllister AU - Windom M AD - Duke Department of Pediatrics (S Armstrong, M Windom, and JS Li), Durham, NC. FAU - Li, Jennifer S AU - Li JS AD - Duke Department of Pediatrics (S Armstrong, M Windom, and JS Li), Durham, NC. FAU - Shah, Svati H AU - Shah SH AD - Duke Department of Medicine (SH Shah, WE Kraus), Durham, NC. FAU - Story, Mary AU - Story M AD - Duke Global Health Institute (M Story), Durham, NC. FAU - Zucker, Nancy AU - Zucker N AD - Duke University School of Medicine (AB Scott, N Zucker, and E Schwark), Durham, NC. FAU - Kraus, William E AU - Kraus WE AD - Duke Department of Medicine (SH Shah, WE Kraus), Durham, NC. FAU - Zizzi, Alexandra R AU - Zizzi AR AD - Duke Department of Population Health Sciences (AR Zizzi, AC Skinner, and CD Neshteruk), Durham, NC. FAU - Schwark Ii, Earl AU - Schwark Ii E AD - Duke University School of Medicine (AB Scott, N Zucker, and E Schwark), Durham, NC. FAU - Skinner, Asheley C AU - Skinner AC AD - Duke Department of Population Health Sciences (AR Zizzi, AC Skinner, and CD Neshteruk), Durham, NC. FAU - Neshteruk, Cody D AU - Neshteruk CD AD - Duke Department of Population Health Sciences (AR Zizzi, AC Skinner, and CD Neshteruk), Durham, NC. LA - eng SI - ClinicalTrials.gov/NCT03339440 GR - K12 HL138030/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20260326 PL - United States TA - Acad Pediatr JT - Academic pediatrics JID - 101499145 SB - IM MH - Humans MH - Child MH - *Primary Health Care MH - Adolescent MH - Female MH - Child, Preschool MH - Electronic Health Records MH - Male MH - Feasibility Studies MH - *Patient Selection MH - *Pediatric Obesity/therapy MH - Randomized Controlled Trials as Topic MH - Practice Guidelines as Topic MH - Body Mass Index PMC - PMC13684880 MID - NIHMS2167862 OTO - NOTNLM OT - clinical research OT - obesity OT - pediatric OT - recruitment COIS- Declarations of Competing Interest The authors have no conflicts of interest to disclose. EDAT- 2026/03/29 07:35 MHDA- 2026/06/11 05:38 PMCR- 2026/10/21 CRDT- 2026/03/28 20:15 PHST- 2025/07/30 00:00 [received] PHST- 2026/03/12 00:00 [revised] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/06/11 05:38 [medline] PHST- 2026/03/29 07:35 [pubmed] PHST- 2026/03/28 20:15 [entrez] PHST- 2026/10/21 00:00 [pmc-release] AID - S1876-2859(26)00092-6 [pii] AID - 10.1016/j.acap.2026.103310 [doi] PST - ppublish SO - Acad Pediatr. 2026 May-Jun;26(4):103310. doi: 10.1016/j.acap.2026.103310. Epub 2026 Mar 26. PMID- 41903344 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260713 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 147 DP - 2026 Jul TI - Understanding household economic influences on child stunting: A cross-sectional study in Eastern Uganda. PG - 113187 LID - S0899-9007(26)00095-X [pii] LID - 10.1016/j.nut.2026.113187 [doi] AB - BACKGROUND: Child stunting is a significant public health concern in rural Uganda, where poverty and food insecurity are prevalent. This study aimed to examine how household economic factors influence child stunting in a rural district of Eastern Uganda and to assess whether food security moderates this relationship. METHODS: A cross-sectional study was conducted involving 289 children aged 24-59 months in Namutumba District, Eastern Uganda. Data were collected on household asset-based wealth, food security, and household income diversification using a validated questionnaire, while anthropometric measurements of children were obtained using standard measurement procedures. Prevalence rate ratios were calculated to determine the association between household economic factors and child stunting using modified Poisson regression, and the moderating effect of food security was assessed on the additive scale using predictive margins. RESULTS: The prevalence of stunting was 28%. Household asset-based wealth was not significantly associated with stunting. However, household income diversification showed an inverse association with stunting. Children from households with two or more income-earning members had a significantly lower prevalence of stunting compared to those with none (adjusted prevalence rate ratio = 0.50; 95% confidence interval: 0.26, 0.97). Among severely food-insecure households, the predicted probability of stunting was 23% lower (95% confidence interval: -2.8%, -43.4%) for children living in households with multiple income earners compared with those in households with no income earners. CONCLUSIONS: While asset-based wealth was not associated with child stunting, household income diversification proved to be protective. These findings indicate considerations for interventions that integrate multiple income generation with food security strategies to reduce child stunting in this population. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Matovu, Nicholas AU - Matovu N AD - Centre for Public Health, Faculty of Medicine, Health and Life Sciences, Queen's University Belfast, Belfast, United Kingdom; Department of Biological Sciences, Faculty of Science, Kyambogo University, Kampala, Uganda. Electronic address: n.matovu@qub.ac.uk. FAU - Kizito, Ndegeya AU - Kizito N AD - Department of Nutrition Sciences and Dietetics, Faculty of Vocational Studies, Kyambogo University, Kampala, Uganda. FAU - Aljohani, Motab AU - Aljohani M AD - Department of Public Health, Saudi Electronic University, Riyadh, Kingdom of Saudi Arabia. LA - eng PT - Journal Article DEP - 20260305 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Humans MH - Uganda/epidemiology MH - Cross-Sectional Studies MH - *Growth Disorders/epidemiology MH - Female MH - Child, Preschool MH - Male MH - *Family Characteristics MH - Prevalence MH - *Socioeconomic Factors MH - Rural Population/statistics & numerical data MH - *Income/statistics & numerical data MH - Infant MH - Poverty/statistics & numerical data MH - Food Security MH - Food Insecurity MH - Food Supply/statistics & numerical data OTO - NOTNLM OT - Child stunting OT - Food insecurity OT - Household income dynamics OT - Nutrition-sensitive interventions OT - Rural Uganda OT - Socioeconomic status COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/29 07:35 MHDA- 2026/04/21 17:43 CRDT- 2026/03/28 19:03 PHST- 2025/09/05 00:00 [received] PHST- 2026/02/08 00:00 [revised] PHST- 2026/02/22 00:00 [accepted] PHST- 2026/04/21 17:43 [medline] PHST- 2026/03/29 07:35 [pubmed] PHST- 2026/03/28 19:03 [entrez] AID - S0899-9007(26)00095-X [pii] AID - 10.1016/j.nut.2026.113187 [doi] PST - ppublish SO - Nutrition. 2026 Jul;147:113187. doi: 10.1016/j.nut.2026.113187. Epub 2026 Mar 5. PMID- 41903076 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260627 LR - 20260813 IS - 2731-4383 (Electronic) IS - 2731-4383 (Linking) VI - 6 IP - 1 DP - 2026 Mar 28 TI - Psychological benefits of physical-sport practice in recent mothers. LID - 10.1007/s44192-026-00440-5 [doi] LID - 83 AB - This study examines the relationship between physical-sport activity and mental health in women during the postpartum period, assessing negative variables (depression, anxiety, and stress) and positive ones (resilience and grit). A total of 328 women from Andalusia (Spain) participated, engaging in 240-300 min of weekly physical activity in accordance with WHO recommendations, and having given birth within the previous six weeks. Validated scales (DASS-21, RS-14, and GRIT-O) were administered, and activity levels were measured using Wold's (Health-Behavior in schoolchildren: a WHO cross-national Survey. Resource package questions 1993-94, Norway: Universidad de Bergen, Noruega, 1995) questionnaire. The analysis included descriptive statistics, reliability coefficients, Pearson correlations, and multiple linear regressions to assess the association between physical-sport activity and psychological variables. Results showed that such activity was significantly associated with lower levels of depression, anxiety, and stress, and with higher levels of resilience and grit. These findings confirm previous evidence on the benefits of exercise for perinatal mental health and provide novel insights into its role in strengthening positive psychological resources. It is concluded that promoting physical activity programs tailored to the needs of new mothers may be an integral strategy to prevent emotional distress and enhance key personal competencies. FAU - Aguilar-Parra, Jose M AU - Aguilar-Parra JM AD - Department of Psychology, Hum-878 Research Team, Health Research Centre, University of Almeria, Ctra. de Sacramento S/N, 04120, La Canada de San Urbano, Almeria, Spain. FAU - Trigueros, Ruben AU - Trigueros R AD - Department of Psychology, Hum-878 Research Team, Health Research Centre, University of Almeria, Ctra. de Sacramento S/N, 04120, La Canada de San Urbano, Almeria, Spain. rtr088@ual.es. FAU - Fernandez-Ortega, Carmen AU - Fernandez-Ortega C AD - Department of Psychology, Hum-878 Research Team, Health Research Centre, University of Almeria, Ctra. de Sacramento S/N, 04120, La Canada de San Urbano, Almeria, Spain. FAU - Del Mar Miralles-Dioni, Maria AU - Del Mar Miralles-Dioni M AD - Department of Psychology, Hum-878 Research Team, Health Research Centre, University of Almeria, Ctra. de Sacramento S/N, 04120, La Canada de San Urbano, Almeria, Spain. LA - eng PT - Journal Article DEP - 20260328 PL - Switzerland TA - Discov Ment Health JT - Discover mental health JID - 9918350483906676 PMC - PMC13149799 OTO - NOTNLM OT - Grit OT - Mental health OT - Physical-sport activity OT - Postpartum OT - Resilience COIS- Declarations. Consent to publication: Not applicable. Ethical approval and consent to participate: The present study was approved by the Bioethics Committee of the University of Almeria (REF: UALBIO2024/007). In addition, all procedures performed in the studies with human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its subsequent amendments or comparable ethical standards. Informed consent: Informed consent was obtained from all individual participants included in the study. Human and animal rights: All participants in the study agreed to participate freely and without any external pressure or reward. Competing Interests: The authors declare no competing interests. EDAT- 2026/03/29 07:34 MHDA- 2026/03/29 07:35 PMCR- 2026/03/28 CRDT- 2026/03/28 12:20 PHST- 2025/09/18 00:00 [received] PHST- 2026/03/24 00:00 [accepted] PHST- 2026/03/29 07:35 [medline] PHST- 2026/03/29 07:34 [pubmed] PHST- 2026/03/28 12:20 [entrez] PHST- 2026/03/28 00:00 [pmc-release] AID - 10.1007/s44192-026-00440-5 [pii] AID - 440 [pii] AID - 10.1007/s44192-026-00440-5 [doi] PST - epublish SO - Discov Ment Health. 2026 Mar 28;6(1):83. doi: 10.1007/s44192-026-00440-5. PMID- 41902909 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20261010 IS - 1432-198X (Electronic) IS - 0931-041X (Linking) VI - 41 IP - 9 DP - 2026 Sep TI - Lung ultrasound: a complementary dynamic method to estimate target weight in pediatric hemodialysis. PG - 2951-2959 LID - 10.1007/s00467-026-07272-z [doi] AB - BACKGROUND: Target weight assessment remains challenging, particularly in children, where ongoing growth adds complexity. Lung ultrasound (LUS) has emerged as a promising tool for assessing hydration, although pediatric data are limited. METHODS: We conducted a retrospective, single-center study between January and September 2024. Target weight was assessed using clinical examination, pre-dialysis NT-proBNP level, relative overhydration by bioimpedance analysis (BIA), inferior vena cava (IVC) diameter, and LUS score (12-zone protocol). The primary outcome was the association between LUS and other assessment methods. Secondary outcomes included the reliability of LUS with dialysis-related weight loss and its contribution to multimodal evaluation. Mixed-effects regression models were used. RESULTS: Sixty-eight dialysis sessions of 10 children on hemodialysis were analyzed. The median pre-dialysis LUS score was 7 (IQR 5-9), which decreased to 4 (IQR 3-6) post-dialysis. LUS correlated significantly with NT-proBNP level (p = 0.006) but not with BIA or IVC. A trend was observed for clinical signs (p = 0.072). Changes in the LUS score correlated with dialysis-related weight loss (p < 0.001). CONCLUSIONS: LUS is a sensitive, dynamic complementary tool for assessing target weight in pediatric hemodialysis patients. It provides additional information on extravascular fluid status and should be considered within multimodal target weight strategies, especially in cases of discordance. CI - (c) 2026. The Author(s), under exclusive licence to International Pediatric Nephrology Association. FAU - Moussler, Benjamin AU - Moussler B AUID- ORCID: 0009-0002-0876-9992 AD - Pediatric Nephrology Department, University Hospital of Nancy, Nancy, 54000, France. b.moussler2@chru-nancy.fr. FAU - Wiedemann, Arnaud AU - Wiedemann A AD - Pediatric Intensive Care Unit, University Regional Hospital Center of Nancy, Nancy, F-54000, France. AD - University Regional Hospital Center. of Nancy, INSERM UMRS 1256 NGERE-Nutrition, Genetics, and Environmental Risk Exposure, Nancy, 54000, France. FAU - Mirguet, Anne AU - Mirguet A AD - Pediatric Nephrology Department, University Hospital of Nancy, Nancy, 54000, France. FAU - Camoin-Schweitzer, Marie-Christine AU - Camoin-Schweitzer MC AD - Pediatric Nephrology Department, University Hospital of Nancy, Nancy, 54000, France. FAU - Luc, Amandine AU - Luc A AD - DRCI, MPI Department, Methodology, Data Management and Statistics Unit, University Hospital of Nancy, Nancy, France. FAU - Jeanbert, Elodie AU - Jeanbert E AD - DRCI, MPI Department, Methodology, Data Management and Statistics Unit, University Hospital of Nancy, Nancy, France. FAU - Vrillon, Isabelle AU - Vrillon I AD - Pediatric Nephrology Department, University Hospital of Nancy, Nancy, 54000, France. FAU - Grosyeux, Chloe AU - Grosyeux C AD - Pediatric Nephrology Department, University Hospital of Nancy, Nancy, 54000, France. LA - eng PT - Journal Article DEP - 20260328 PL - Germany TA - Pediatr Nephrol JT - Pediatric nephrology (Berlin, Germany) JID - 8708728 RN - 0 (Peptide Fragments) RN - 0 (pro-brain natriuretic peptide (1-76)) RN - 114471-18-0 (Natriuretic Peptide, Brain) SB - IM MH - Humans MH - *Renal Dialysis/adverse effects MH - Female MH - Male MH - Ultrasonography/methods MH - Child MH - Retrospective Studies MH - *Lung/diagnostic imaging MH - Adolescent MH - Child, Preschool MH - Vena Cava, Inferior/diagnostic imaging MH - Peptide Fragments/blood MH - *Body Weight MH - Electric Impedance MH - Natriuretic Peptide, Brain/blood MH - *Kidney Failure, Chronic/therapy MH - Reproducibility of Results MH - Weight Loss OTO - NOTNLM OT - Biompedance spectroscopy OT - Hemodialysis OT - Inferior vena cava OT - Lung ultrasound OT - NT-proBNP OT - Pediatrics OT - Target weight COIS- Declarations. Ethics approval and consent to participate: This retrospective study was approved by the local ethical committee (Comite d'Ethique du CHRU de Nancy, saisine no. 556). Non-opposition procedure was applied, as displayed in the Pediatric Dialysis Unit of the center (2024PI-200). Conflict of interest: The authors declare no competing interests. EDAT- 2026/03/29 07:34 MHDA- 2026/07/30 12:43 CRDT- 2026/03/28 12:13 PHST- 2025/12/13 00:00 [received] PHST- 2026/03/12 00:00 [accepted] PHST- 2026/02/26 00:00 [revised] PHST- 2026/07/30 12:43 [medline] PHST- 2026/03/29 07:34 [pubmed] PHST- 2026/03/28 12:13 [entrez] AID - 10.1007/s00467-026-07272-z [pii] AID - 10.1007/s00467-026-07272-z [doi] PST - ppublish SO - Pediatr Nephrol. 2026 Sep;41(9):2951-2959. doi: 10.1007/s00467-026-07272-z. Epub 2026 Mar 28. PMID- 41901917 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 6 DP - 2026 Mar 10 TI - Validity, Reliability and Interpretability of an IMU-Based System to Measure 3D Lower Limb Kinematics of Patients with Heterogeneous Gait Disorders. LID - 10.3390/s26061746 [doi] LID - 1746 AB - Inertial measurement units (IMUs) represent a promising alternative to optoelectronic systems for estimating gait kinematics in less resource-intensive laboratories. However, evidence regarding the clinical interpretability of IMU-based gait analysis in pathological populations remains limited. This study aimed to evaluate the concurrent validity, reliability, and interpretability of an IMU-based method for computing 3D lower limb kinematics in asymptomatic and pathological populations. Fifty-five participants, including asymptomatic individuals (AS, n = 15), patients with cerebral palsy (CP, n = 15), and individuals with various motor disorders (OMD, n = 25), were assessed using a 7-IMU system and an optoelectronic system. Validity was quantified using root mean square error (RMSE), centered RMSE, and Pearson correlation coefficients (CCs) across 11 commonly reported lower limb kinematic outcomes. Reliability was assessed using intraclass correlation coefficients (ICCs), and interpretability was examined by comparing Gait Profile Scores (GPS) derived from both systems. Mean RMSE values were 7.1 degrees (AS), 9.8 degrees (CP), and 9.3 degrees (OMD), with centered RMSE values below 3.2 degrees . The correlation between IMU- and optoelectronic-based kinematics was good to excellent (mean CC = 0.76). Reliability ranged from moderate to excellent, and GPS showed moderate agreement between systems (CC = 0.42). These findings support the clinical validity, reliability, and interpretability of IMU-based gait kinematics across heterogeneous gait disorders. FAU - Carcreff, Lena AU - Carcreff L AUID- ORCID: 0000-0003-0086-4944 AD - Kinesiology Laboratory, Geneva University Hospitals and Geneva University, 1205 Geneva, Switzerland. AD - Department of Physical Medicine and Rehabilitation, University Hospital of Angers, 49100 Angers, France. FAU - Payen, Gabriel AU - Payen G AD - MindMaze, 1006 Lausanne, Switzerland. FAU - Grouvel, Gautier AU - Grouvel G AUID- ORCID: 0000-0002-2797-7677 AD - Kinesiology Laboratory, Geneva University Hospitals and Geneva University, 1205 Geneva, Switzerland. AD - Center of Research on Skeletal Muscle and Movement, Geneva University Hospitals and Geneva University, 1205 Geneva, Switzerland. FAU - Cardoso-Fonseca, Mickael AU - Cardoso-Fonseca M AD - Kinesiology Laboratory, Geneva University Hospitals and Geneva University, 1205 Geneva, Switzerland. FAU - Masse, Fabien AU - Masse F AD - MindMaze, 1006 Lausanne, Switzerland. FAU - Armand, Stephane AU - Armand S AUID- ORCID: 0000-0001-9144-4982 AD - Kinesiology Laboratory, Geneva University Hospitals and Geneva University, 1205 Geneva, Switzerland. AD - Center of Research on Skeletal Muscle and Movement, Geneva University Hospitals and Geneva University, 1205 Geneva, Switzerland. LA - eng GR - 38215.1 IP-LS/Innosuisse - Swiss Innovation Agency/ PT - Journal Article DEP - 20260310 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - Biomechanical Phenomena/physiology MH - Female MH - *Lower Extremity/physiopathology/physiology MH - Male MH - *Gait/physiology MH - Reproducibility of Results MH - Adult MH - *Gait Analysis/methods MH - Cerebral Palsy/physiopathology MH - Young Adult MH - Adolescent MH - Middle Aged MH - *Gait Disorders, Neurologic/physiopathology PMC - PMC13030621 OTO - NOTNLM OT - clinical gait analysis OT - concurrent validity OT - inertial measurement units OT - interpretability OT - lower limb kinematics OT - reliability COIS- F. Masse and G. Payen were employed by Mindmaze SA when the study was conducted. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/28 06:40 MHDA- 2026/03/28 06:41 PMCR- 2026/03/10 CRDT- 2026/03/28 01:34 PHST- 2025/12/31 00:00 [received] PHST- 2026/02/14 00:00 [revised] PHST- 2026/03/04 00:00 [accepted] PHST- 2026/03/28 06:41 [medline] PHST- 2026/03/28 06:40 [pubmed] PHST- 2026/03/28 01:34 [entrez] PHST- 2026/03/10 00:00 [pmc-release] AID - s26061746 [pii] AID - sensors-26-01746 [pii] AID - 10.3390/s26061746 [doi] PST - epublish SO - Sensors (Basel). 2026 Mar 10;26(6):1746. doi: 10.3390/s26061746. PMID- 41901149 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260925 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 6 DP - 2026 Mar 19 TI - Fruit and Vegetable Parenting Practices in Preschoolers: Initial Examination and Cultural Equivalency of a New Measure. LID - 10.3390/nu18060974 [doi] LID - 974 AB - Background: Encouraging fruit and vegetable (FV) consumption early in childhood is important for long-term healthy eating. Though parents play an important role in shaping children's FV-related taste preferences and consumption, validated instruments assessing the range of parenting practices that specifically support young children's FV intake are scarce. Furthermore, little attention has been given to low-income families, cultural inclusivity, and FV practices across different settings. The current study sought to conduct an initial examination and explore the measurement equivalency of a new FV parenting practices questionnaire (FVPPQ) across racially/ethnically diverse groups that address these gaps. Methods: Data for this paper came from a large project focused on parents' FV parenting practices with young children enrolled in Head Start programs in the southern part of the U.S. Inclusion criteria were (a) parent/legal guardian being eighteen or older, (b) being the primary person responsible for child feeding, and (c) the child not requiring a special diet (e.g., diabetic). Using a multi-phases project approach, we (1) developed a preliminary conceptual map of parenting practice domains by reviewing existing measures on FV parenting practices; (2) completed and content-analyzed data from 18 focus groups (n = 62) to identify and further revise the preliminary conceptual map of domains, (3) administered a questionnaire with 11 domains of FV parenting practices, and then (4) empirically explored and reduced the measure while evaluating its content, construct, and criterion validity, and cultural equivalency across Non-Hispanic White, Hispanic White, and Black parents (n = 281). Results: Findings from Phases 1 and 2 generated a 107-item questionnaire that was reduced during phase 3 through a series of principal component and confirmatory factor analyses to the final FVPPQ with 21 items in four unique domains, showing good variability and inter-item consistency reliability: (1) Availability (5 items); (2) modeling (5 items); child-focused (5 items); and pressure (6 items). Three of the four domains evidenced cultural equivalency. Conclusions: The FVPPQ with four unique subscales demonstrated good content, construct validity, and partial measurement equivalency across racially/ethnically diverse groups of parents. Further confirmatory validation is warranted in larger samples, but the FVPPQ might be a promising and easily administered measure for research and applied interventions in nutrition, health behavior, and parenting contexts. FAU - Shriver, Lenka H AU - Shriver LH AUID- ORCID: 0000-0002-3125-333X AD - Department of Nutrition, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, NC 27402-6170, USA. FAU - Buehler, Cheryl AU - Buehler C AUID- ORCID: 0000-0003-3970-0883 AD - Human Development and Family Studies, University of North Carolina at Greensboro, P.O. Box 26170, Greensboro, NC 27402-6170, USA. LA - eng GR - NA/University of North Carolina Greensboro, Internal Funding, School of Health and Human Sciences/ PT - Journal Article DEP - 20260319 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Vegetables MH - *Parenting/ethnology MH - *Fruit MH - Child, Preschool MH - Surveys and Questionnaires MH - Male MH - Food Preferences MH - Female MH - Focus Groups MH - Parents/psychology MH - Parent-Child Relations MH - Adult MH - *Feeding Behavior MH - *Diet, Healthy PMC - PMC13029407 OTO - NOTNLM OT - fruit and vegetable consumption OT - measure development OT - measurement equivalency OT - parenting practices OT - preschool-aged children COIS- The authors declare no conflicts of interest. EDAT- 2026/03/28 06:39 MHDA- 2026/03/28 06:40 PMCR- 2026/03/19 CRDT- 2026/03/28 01:31 PHST- 2026/02/16 00:00 [received] PHST- 2026/03/13 00:00 [revised] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/03/28 06:40 [medline] PHST- 2026/03/28 06:39 [pubmed] PHST- 2026/03/28 01:31 [entrez] PHST- 2026/03/19 00:00 [pmc-release] AID - nu18060974 [pii] AID - nutrients-18-00974 [pii] AID - 10.3390/nu18060974 [doi] PST - epublish SO - Nutrients. 2026 Mar 19;18(6):974. doi: 10.3390/nu18060974. PMID- 41901104 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 6 DP - 2026 Mar 16 TI - Adaptation and Validation of the Gluten-Free Perceived Nutrition Environment Measures Survey (NEMS-P-GF) and Its Association with Gluten-Free Diet Adherence Among Adults with Celiac Disease in Chile. LID - 10.3390/nu18060929 [doi] LID - 929 AB - Background/Objectives: Strict adherence to a gluten-free diet (GFD) is the only effective treatment for celiac disease (CeD) but remains challenging due to structural and environmental barriers. Evidence on these determinants in Latin America is scarce. This study aimed to adapt and validate the Gluten-Free Perceived Nutrition Environment Measures Survey (NEMS-P-GF) for adults with CeD in Chile and examine its association with GFD adherence. Methods: A cross-sectional online survey (October 2023-January 2024) included adults (>/=18 years) with biopsy- or serology-confirmed CeD (n = 233). The questionnaire collected sociodemographic and clinical data, assessed adherence using the Celiac Dietary Adherence Test (CDAT; good < 13, poor >/= 13), and measured perceptions of home and supply food environments via the adapted NEMS-P-GF. Construct validity was tested using exploratory factor analysis and reliability with Cronbach's alpha and McDonald's omega. Associations with adherence were analyzed using Mann-Whitney U. Results: NEMS-P-GF domains showed adequate validity (KMO 0.71-0.81; Bartlett's p < 0.001) and acceptable-to-excellent reliability (alpha/omega = 0.70-0.90). Participants with good vs. poor adherence perceived more supportive environments, particularly at home (median 4.79 vs. 1.29; p < 0.01) and globally (1.72 vs. -7.25; p < 0.01). Supply environments were perceived as less supportive due to limited availability and high prices (median -3.68 and -7.78), with smaller differences between adherence groups (p = 0.018). Conclusions: Supportive home environments were strongly associated with better GFD adherence, while supply environments remained broadly restrictive, showing modest but significant differences between adherence groups. The NEMS-P-GF demonstrated preliminary evidence of good psychometric properties and offers a valid, context-sensitive tool to assess GF food environments and inform public health strategies for CeD populations. FAU - Vega-Salas, Maria Jesus AU - Vega-Salas MJ AUID- ORCID: 0000-0002-5798-7091 AD - Departamento de Nutricion y Dietetica, Escuela de Ciencias de la Salud, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago 7820436, Chile. AD - Center for Cancer Prevention and Control (CECAN), Santiago 7820436, Chile. FAU - Parada, Alejandra AU - Parada A AUID- ORCID: 0000-0001-9573-2957 AD - Departamento de Nutricion y Dietetica, Escuela de Ciencias de la Salud, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago 7820436, Chile. AD - Departamento de Nutricion, Diabetes y Metabolismo, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago 7820436, Chile. FAU - Hermosilla-Llanca, Danae AU - Hermosilla-Llanca D AUID- ORCID: 0009-0008-0128-534X AD - Departamento de Nutricion y Dietetica, Escuela de Ciencias de la Salud, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago 7820436, Chile. FAU - Berkowitz, Loni AU - Berkowitz L AUID- ORCID: 0000-0002-8562-4845 AD - Departamento de Nutricion, Diabetes y Metabolismo, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago 7820436, Chile. AD - Centro de Nutricion Molecular y Enfermedades Cronicas, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago 8331010, Chile. FAU - Rodriguez Osiac, Lorena AU - Rodriguez Osiac L AUID- ORCID: 0000-0002-7732-2580 AD - Center for Cancer Prevention and Control (CECAN), Santiago 7820436, Chile. AD - Escuela de Salud Publica Dr. Salvador Allende, Universidad de Chile, Santiago 8380453, Chile. FAU - Egana Rojas, Daniel AU - Egana Rojas D AUID- ORCID: 0000-0001-7877-0513 AD - Departamento de Atencion Primaria y Salud Familiar, Facultad de Medicina, Universidad de Chile, Santiago 8900085, Chile. FAU - Rigotti, Attilio AU - Rigotti A AUID- ORCID: 0000-0002-0495-3525 AD - Departamento de Nutricion, Diabetes y Metabolismo, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago 7820436, Chile. AD - Centro de Nutricion Molecular y Enfermedades Cronicas, Escuela de Medicina, Pontificia Universidad Catolica de Chile, Santiago 8331010, Chile. LA - eng GR - Concurso Interdisciplinario de Investigacion Escuela de Medicina y Departamento de Ciencias de la Salud 2023/Pontificia Universidad Catolica de Chile/ PT - Journal Article PT - Validation Study DEP - 20260316 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Celiac Disease/diet therapy/psychology MH - *Diet, Gluten-Free/psychology MH - Chile MH - Female MH - Adult MH - Male MH - *Patient Compliance/statistics & numerical data/psychology MH - Cross-Sectional Studies MH - Middle Aged MH - Reproducibility of Results MH - Young Adult MH - Surveys and Questionnaires MH - Adolescent MH - *Nutrition Surveys PMC - PMC13028700 OTO - NOTNLM OT - celiac disease OT - dietary adherence OT - food environments OT - gluten-free diet OT - structural determinants of diet COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analysis, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results. EDAT- 2026/03/28 06:40 MHDA- 2026/03/28 06:41 PMCR- 2026/03/16 CRDT- 2026/03/28 01:31 PHST- 2025/12/17 00:00 [received] PHST- 2026/01/30 00:00 [revised] PHST- 2026/02/05 00:00 [accepted] PHST- 2026/03/28 06:41 [medline] PHST- 2026/03/28 06:40 [pubmed] PHST- 2026/03/28 01:31 [entrez] PHST- 2026/03/16 00:00 [pmc-release] AID - nu18060929 [pii] AID - nutrients-18-00929 [pii] AID - 10.3390/nu18060929 [doi] PST - epublish SO - Nutrients. 2026 Mar 16;18(6):929. doi: 10.3390/nu18060929. PMID- 41901089 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 6 DP - 2026 Mar 13 TI - Gastrointestinal Symptoms After Sport-Related Concussion in Irish Athletes. LID - 10.3390/nu18060914 [doi] LID - 914 AB - Background/Objectives: Sport-related concussion (SRC) elicits multi-systemic symptoms, including nausea, fatigue, and cognitive changes. Gastrointestinal (GI) symptoms are not well captured in current concussion assessments and may be under-recognised in clinical follow-up. GI disturbances may influence intake tolerance and day-to-day fuelling during post-SRC recovery. This study investigated the prevalence and severity of self-reported GI symptoms in Irish athletes after their most recent SRC, examined sex-based patterns, and evaluated the rationale for integrating GI symptom checks into standard concussion tools (e.g., SCAT6) and post-injury monitoring. Methods: An online survey was completed by recreational, competitive, and elite athletes who retrospectively self-reported concussion history, GI symptoms, and bowel function post-SRC and at the time of survey completion (ToSC; 0.03-216 months post-injury). The survey used the Bristol Stool Chart, Rivermead Post-Concussion Symptoms Questionnaire, and validated GI symptom measures. Descriptive statistics and chi-square tests examined timepoint- and sex-based differences. Results: A total of 106 athletes participated (55.7% female; mean age 26.4 +/- 7.7 years), of whom 90.6% reported >/=1 GI symptom post-SRC, with greater severity observed for appetite loss, bloating, and abdominal discomfort. Bowel habits shifted bidirectionally for 42.5%, and 26.4% were experiencing ongoing symptoms at ToSC. Conclusions: Self-reported GI symptoms were common and appear under-recognised post-SRC. These findings support greater attention to GI symptom assessment and suggest that brief GI checks and facilitated access to nutrition advice where symptoms persist may be feasible within multidisciplinary, athlete-centred care. Prospective studies are needed to determine clinical relevance and to evaluate nutrition-related strategies. FAU - Finnegan, Emma AU - Finnegan E AUID- ORCID: 0009-0006-0426-0346 AD - Department of Sport, Exercise and Nutrition, School of Health, Sport Science and Nutrition, Atlantic Technological University (ATU), Dublin Rd., H91 T8NW Galway, Ireland. FAU - Daly, Ed AU - Daly E AUID- ORCID: 0000-0001-6548-9634 AD - Department of Sport, Exercise and Nutrition, School of Health, Sport Science and Nutrition, Atlantic Technological University (ATU), Dublin Rd., H91 T8NW Galway, Ireland. FAU - Hunzinger, Katherine J AU - Hunzinger KJ AUID- ORCID: 0000-0002-4599-8543 AD - Department of Exercise Science, Thomas Jefferson University, Philadelphia, PA 19144, USA. AD - Jefferson Center for Injury Research & Prevention, Thomas Jefferson University, Philadelphia, PA 19144, USA. FAU - Ryan, Lisa AU - Ryan L AUID- ORCID: 0000-0002-5505-7130 AD - Department of Sport, Exercise and Nutrition, School of Health, Sport Science and Nutrition, Atlantic Technological University (ATU), Dublin Rd., H91 T8NW Galway, Ireland. LA - eng PT - Journal Article DEP - 20260313 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Female MH - *Gastrointestinal Diseases/epidemiology/etiology MH - *Athletes MH - *Athletic Injuries/complications MH - Ireland/epidemiology MH - *Brain Concussion/complications/epidemiology MH - Adult MH - Young Adult MH - Prevalence MH - Surveys and Questionnaires MH - Retrospective Studies MH - Self Report MH - *Post-Concussion Syndrome/epidemiology MH - Adolescent PMC - PMC13029405 OTO - NOTNLM OT - athlete recovery OT - concussion OT - digestive health OT - energy OT - gastrointestinal symptoms OT - gut-brain axis OT - mild traumatic brain injury OT - nutrition OT - sport injury COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/28 06:39 MHDA- 2026/03/28 06:40 PMCR- 2026/03/13 CRDT- 2026/03/28 01:31 PHST- 2026/01/28 00:00 [received] PHST- 2026/02/23 00:00 [revised] PHST- 2026/03/03 00:00 [accepted] PHST- 2026/03/28 06:40 [medline] PHST- 2026/03/28 06:39 [pubmed] PHST- 2026/03/28 01:31 [entrez] PHST- 2026/03/13 00:00 [pmc-release] AID - nu18060914 [pii] AID - nutrients-18-00914 [pii] AID - 10.3390/nu18060914 [doi] PST - epublish SO - Nutrients. 2026 Mar 13;18(6):914. doi: 10.3390/nu18060914. PMID- 41901070 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 6 DP - 2026 Mar 12 TI - Development and Evaluation of a Functional Food Consumption Index (FunFoCI) in Adults. LID - 10.3390/nu18060895 [doi] LID - 895 AB - BACKGROUND/OBJECTIVES: Functional foods are widely discussed in nutrition research, yet their consumption is rarely quantified using a standardized, food-based metric. We developed the Functional Food Consumption Index (FunFoCI) and conducted an initial evaluation of its performance in adults. METHODS: In this cross-sectional study, 500 adults (>/=18 years, 286 women, 214 men) were assessed using a 210-item quantitative food frequency questionnaire (FFQ) and a 3 day food record (FR). Candidate index foods were evaluated by five experts, using a 4-point Likert scale to establish content validity, and the finalized FunFoCI comprised 100 foods across nine groups: fruits; vegetables; whole grains; legumes; nuts and oilseeds; fermented foods and products; animal-based foods; functional oils; and spices, herbal teas, and functional beverages. FunFoCI scoring used a sample distribution-based percentile approach, including modifications for zero-inflated or sparsely consumed items, followed by group-level normalization (0-1), equal weighting across nine groups, and rescaling to 0-100. FR data were used to examine the between-method feasibility of the scoring approach. The convergent validity was assessed via correlation analyses, with the Diet Quality Index-International (DQI-I) and Healthy Eating Index-2015 (HEI-2015) derived from both FFQ and FR data, and additional correlation analyses and robustness checks were conducted to examine associations among key study variables. Known group patterns were examined across sociodemographic, lifestyle, and anthropometric characteristics. RESULTS: Content evaluation supported index coverage (S-CVI/Ave = 0.912; S-CVI/UA = 0.877; mean modified kappa = 0.899). The mean FunFoCI total scores were 32.68 +/- 11.92 (FFQ) and 13.29 +/- 4.65 (FR). Participants were classified into low (32.8%, n = 164), moderate (33.0%, n = 165), and high (34.2%, n = 171) FunFoCI categories. FunFoCI correlated with FFQ-derived DQI-I and HEI-2015 (r = 0.367 and r = 0.368; both p < 0.001), and both indices increased across ascending FunFoCI total scores (p < 0.001). The FFQ-derived FunFoCI total score was correlated with the FR-derived FunFoCI score (r = 0.294; p < 0.001). FunFoCI scores showed differences across participant sociodemographic, lifestyle and anthropometric characteristics. CONCLUSIONS: FunFoCI is a newly developed, expert-reviewed, food-based index with transparent, sample distribution-based scoring and normalized aggregation. Its initial evaluation supports its use for the standardized quantification of relative functional food consumption in adults, while further studies should assess the reliability and external validation criteria in other populations and study designs. FAU - Arman, Gulden AU - Arman G AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Artvin Coruh University, Artvin 08000, Turkey. AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06100, Turkey. FAU - Akyol, Asli AU - Akyol A AUID- ORCID: 0000-0001-6301-6358 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hacettepe University, Ankara 06100, Turkey. LA - eng PT - Journal Article DEP - 20260312 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adult MH - Male MH - Cross-Sectional Studies MH - *Functional Food MH - Middle Aged MH - Reproducibility of Results MH - Young Adult MH - Diet Records MH - *Diet, Healthy MH - *Diet Surveys MH - Feeding Behavior MH - Adolescent MH - Surveys and Questionnaires PMC - PMC13029523 OTO - NOTNLM OT - diet quality index-international (DQI-I) OT - food frequency questionnaire (FFQ) OT - functional food consumption index (FunFoCI) OT - functional foods OT - healthy eating index-2015 (HEI-2015) COIS- The authors declare no conflicts of interest. EDAT- 2026/03/28 06:39 MHDA- 2026/03/28 06:40 PMCR- 2026/03/12 CRDT- 2026/03/28 01:31 PHST- 2026/01/28 00:00 [received] PHST- 2026/03/02 00:00 [revised] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/03/28 06:40 [medline] PHST- 2026/03/28 06:39 [pubmed] PHST- 2026/03/28 01:31 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - nu18060895 [pii] AID - nutrients-18-00895 [pii] AID - 10.3390/nu18060895 [doi] PST - epublish SO - Nutrients. 2026 Mar 12;18(6):895. doi: 10.3390/nu18060895. PMID- 41900534 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260328 LR - 20260813 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 11 IP - 1 DP - 2026 Mar 21 TI - Evaluating the Effect of the Schroth Method on Sensorimotor Control in Adolescents with Idiopathic Scoliosis: A Controlled Clinical Trial. LID - 10.3390/jfmk11010127 [doi] LID - 127 AB - Background: Adolescent idiopathic scoliosis (AIS) is often associated with central nervous system disorders and deficits in sensorimotor function. While the Schroth method is a common clinical intervention, research evidence regarding its effectiveness in enhancing sensorimotor control remains limited. This study aimed to evaluate the impact of the Schroth method on sensorimotor control and quality of life (QoL) in AIS patients. Methods: Sixty female participants (mean age 13.4 years) with Cobb angles between 10 degrees and 45 degrees were divided into an intervention group (n = 30), receiving Schroth exercises and bracing for 10 weeks, and a control group (n = 30), receiving bracing alone. Outcome measures included static and dynamic balance, spine lateral flexion joint position sense (JPS), upper-limb functional proprioception, and the GR-BSSQ Brace questionnaire. Results: Statistical analysis using two-way mixed ANOVA revealed significant Group x Time interactions across several parameters. The Schroth group showed significant improvements in static and dynamic balance, with ellipse area reduction (p = 0.005) and reduced Fukuda test distance (p = 0.007), respectively. Significant enhancements were noted in spine lateral flexion JPS (Bilateral p = 0.008) and upper-limb proprioception (Bilateral p = 0.000). Furthermore, the intervention group reported a significant improvement in QoL scores compared to the control (p = 0.000). Conclusions: The findings demonstrate that the Schroth method was associated with enhanced sensorimotor control, supporting its use as a targeted approach to improve functional outcomes in individuals with AIS. These results highlight the clinical value of the method, beyond spinal curve correction. FAU - Kastrinis, Alexandros AU - Kastrinis A AUID- ORCID: 0009-0005-0149-2590 AD - Health Assessment and Quality of Life Research Laboratory, Department of Physiotherapy, Faculty of Health Sciences, University of Thessaly, 35132 Lamia, Greece. FAU - Strimpakos, Nikolaos AU - Strimpakos N AUID- ORCID: 0000-0002-1287-1028 AD - Health Assessment and Quality of Life Research Laboratory, Department of Physiotherapy, Faculty of Health Sciences, University of Thessaly, 35132 Lamia, Greece. FAU - Koumantakis, George A AU - Koumantakis GA AUID- ORCID: 0000-0001-7709-2802 AD - Research Laboratory of Advanced Physiotherapy, Department of Physiotherapy, University of Western Attica, 12243 Athens, Greece. FAU - Tzatzaliaris, Dionysios AU - Tzatzaliaris D AD - Scoliosis Spine Laser Center, Moschato, 18345 Attica, Greece. FAU - Oikonomaki, Marianna AU - Oikonomaki M AUID- ORCID: 0009-0001-4520-7174 AD - Scoliosis Spine Laser Center, Moschato, 18345 Attica, Greece. FAU - Dimitriadis, Zacharias AU - Dimitriadis Z AD - Health Assessment and Quality of Life Research Laboratory, Department of Physiotherapy, Faculty of Health Sciences, University of Thessaly, 35132 Lamia, Greece. LA - eng PT - Journal Article DEP - 20260321 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC13027788 OTO - NOTNLM OT - Fukuda OT - Schroth OT - balance OT - footplate OT - joint position sense OT - proprioception OT - repeatability OT - scoliosis OT - sensorimotor control OT - spine COIS- First Author A.K., is a certified Schroth instructor. Author D.T. is the owner of the company Scoliosis Spine Laser Center where author M.K. was employed. Furthermore, the Scoliosis Spine Laser Center has a Memorandum of Understanding (MOU) for research collaboration with the Health Assessment and Quality of Life Research Laboratory Department of Physiotherapy at the University of Thessaly. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/28 06:40 MHDA- 2026/03/28 06:41 PMCR- 2026/03/21 CRDT- 2026/03/28 01:29 PHST- 2026/01/19 00:00 [received] PHST- 2026/03/15 00:00 [revised] PHST- 2026/03/18 00:00 [accepted] PHST- 2026/03/28 06:41 [medline] PHST- 2026/03/28 06:40 [pubmed] PHST- 2026/03/28 01:29 [entrez] PHST- 2026/03/21 00:00 [pmc-release] AID - jfmk11010127 [pii] AID - jfmk-11-00127 [pii] AID - 10.3390/jfmk11010127 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2026 Mar 21;11(1):127. doi: 10.3390/jfmk11010127. PMID- 41899873 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260328 LR - 20260813 IS - 2306-5354 (Print) IS - 2306-5354 (Electronic) IS - 2306-5354 (Linking) VI - 13 IP - 3 DP - 2026 Mar 15 TI - Electrogastrography-Derived Mean Power Ratio as an Exploratory Objective Measure of Feeding Intolerance in Preterm Infants. LID - 10.3390/bioengineering13030342 [doi] LID - 342 AB - Feeding intolerance (FI) is common in preterm infants and disrupts enteral nutrition. Because clinical signs of FI are nonspecific, objective biomarkers are needed. In this exploratory study, we evaluated whether electrogastrography (EGG) can distinguish infants with FI from those with no FI (NFI) based on their gastric response to feeding. For each infant, the first available weekly EGG recording (postnatal week 1 or, if unavailable, week 2), comprising two consecutive feeding cycles, was analyzed. Each recording included pre-, during-, and post-feed segments. Power spectral density (PSD) was computed over 0.5-9 cycles per minute (cpm) to derive baseline mean PSD (mPSD) and PSD ratios (PSDR) for during/pre- and post/pre-feeding (PSDR(Dur/Pre), PSDR(Post/Pre)). Mean power ratios (mPR) were calculated across bradygastria, normogastria, and tachygastria frequency bands. Group differences were assessed using bootstrap resampling. Eighty-four infants were analyzed (75 NFI, 9 FI). Baseline mPSD values were comparable between the two groups. FI infants demonstrated lower PSDR(Dur/Pre) values in the bradygastria and tachygastria bands, whereas normogastria responses were similar. No differences were observed in PSDR(Post/Pre). EGG detected attenuated gastric activity specifically during feeding and not after feeding in infants with FI, supporting its potential as a non-invasive physiologic marker that warrants further validation. FAU - Norasteh, Soheila AU - Norasteh S AD - Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA. FAU - Roblyer, Lindsay AU - Roblyer L AD - Division of Neonatal-Perinatal Medicine, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390, USA. FAU - Sanghavi, Rinarani AU - Sanghavi R AD - Division of Pediatric Gastroenterology, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390, USA. FAU - Liu, Hanli AU - Liu H AUID- ORCID: 0000-0002-9312-5691 AD - Department of Bioengineering, University of Texas at Arlington, Arlington, TX 76019, USA. FAU - Ortigoza, Eric B AU - Ortigoza EB AUID- ORCID: 0000-0001-8227-7529 AD - Division of Neonatal-Perinatal Medicine, Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX 75390, USA. LA - eng GR - N/A/Children's Health/ GR - UL1 TR003163/TR/NCATS NIH HHS/United States GR - K23HD108443/Eunice Kennedy Shriver National Institute of Child Health and Human Development/ GR - K23 HD108443/HD/NICHD NIH HHS/United States GR - UL1TR003163/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20260315 PL - Switzerland TA - Bioengineering (Basel) JT - Bioengineering (Basel, Switzerland) JID - 101676056 PMC - PMC13024160 OTO - NOTNLM OT - electrogastrography OT - feeding intolerance OT - neonates OT - power spectral density OT - preterm infants COIS- E.B.O. has Patent #US10478116 B2 through the University of Florida Research Foundation, Inc., there are no competing financial interests. R.S. is a consultant for Allergan and is a member on the Speaker's Bureau for Abbott Nutrition. The other authors have no conflicts of interest to disclose. EDAT- 2026/03/28 06:40 MHDA- 2026/03/28 06:41 PMCR- 2026/03/15 CRDT- 2026/03/28 01:27 PHST- 2026/02/20 00:00 [received] PHST- 2026/03/11 00:00 [revised] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/03/28 06:41 [medline] PHST- 2026/03/28 06:40 [pubmed] PHST- 2026/03/28 01:27 [entrez] PHST- 2026/03/15 00:00 [pmc-release] AID - bioengineering13030342 [pii] AID - bioengineering-13-00342 [pii] AID - 10.3390/bioengineering13030342 [doi] PST - epublish SO - Bioengineering (Basel). 2026 Mar 15;13(3):342. doi: 10.3390/bioengineering13030342. PMID- 41899775 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 3 DP - 2026 Mar 20 TI - A Bifactor Measure of Societal Stigma Toward Eating Disorders and Obesity: Scale Development and Validation. LID - 10.3390/ijerph23030399 [doi] LID - 399 AB - BACKGROUND: Societal stigma toward eating disorders and obesity remains pervasive and is associated with psychological distress, maladaptive eating behaviors, reduced help-seeking, and barriers to care. Despite its documented impact, comprehensive and psychometrically robust instruments to assess stigma-particularly in Spanish-speaking populations-are scarce. This study aimed to develop and validate a multidimensional measure of societal stigma toward eating disorders and obesity in Spain, grounded in contemporary stigma frameworks. METHODS: A cross-sectional observational study was conducted in a large community sample recruited online (N = 2121). An initial pool of stigma-related items was developed based on theoretical and empirical literature and refined through expert content validation. Psychometric evaluation included item screening, exploratory factor analysis (EFA), confirmatory factor analysis (CFA), bifactor modeling, and reliability assessment. The sample was randomly split for EFA (n = 988) and CFA (n = 658). Associations between stigma scores and sociodemographic and experiential variables were examined. RESULTS: The final 36-item instrument demonstrated excellent psychometric properties. Bifactor analyses supported an essentially unidimensional structure dominated by a strong general stigma factor, with secondary content-specific dimensions (e.g., legitimacy, personal responsibility, visibility, and treatment beliefs). The theory-driven bifactor model showed excellent fit (CFI = 0.991; TLI = 0.990; RMSEA = 0.024). The general factor exhibited high reliability (omega(h) = 0.87). Higher stigma was observed among men, older participants, and individuals without personal or familial experience of eating disorders or obesity. CONCLUSIONS: This study provides a reliable and theoretically grounded instrument for assessing societal stigma toward eating disorders and obesity in Spain. The scale enables systematic research on stigma and offers a valuable tool for public health surveillance, intervention development, and evaluation of anti-stigma initiatives aimed at promoting compassionate and equitable care. FAU - Suso-Ribera, Carlos AU - Suso-Ribera C AD - Rheumatology Research Group, Vall d'Hebron Research Institute, 08035 Barcelona, Spain. AD - Faculty of Health Sciences, Universidad Europea de Canarias, 38300 La Orotava, Spain. FAU - Diaz-Sanahuja, Laura AU - Diaz-Sanahuja L AD - Faculty of Psychology and Speech Therapy, Universidad de Valencia, 46010 Valencia, Spain. FAU - Paredes-Mealla, Macarena AU - Paredes-Mealla M AD - Hospital Provincial Foundation, 12006 Castellon, Spain. FAU - Marsal, Sara AU - Marsal S AD - Rheumatology Research Group, Vall d'Hebron Research Institute, 08035 Barcelona, Spain. AD - Department of Rheumatology, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain. FAU - Almirall, Miriam AU - Almirall M AUID- ORCID: 0000-0002-4874-8013 AD - Rheumatology Research Group, Vall d'Hebron Research Institute, 08035 Barcelona, Spain. AD - Department of Rheumatology, Hospital Universitari Vall d'Hebron, 08035 Barcelona, Spain. LA - eng PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20260320 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - *Feeding and Eating Disorders/psychology MH - *Obesity/psychology MH - *Social Stigma MH - Psychometrics MH - Spain MH - Male MH - Cross-Sectional Studies MH - Female MH - Adult MH - Middle Aged MH - Factor Analysis, Statistical MH - Reproducibility of Results MH - Surveys and Questionnaires MH - Young Adult MH - Adolescent PMC - PMC13026928 OTO - NOTNLM OT - eating disorders OT - obesity OT - psychometric validation OT - scale development OT - stigma COIS- The authors declare no conflicts of interest. EDAT- 2026/03/28 06:40 MHDA- 2026/03/28 06:41 PMCR- 2026/03/20 CRDT- 2026/03/28 01:27 PHST- 2026/02/06 00:00 [received] PHST- 2026/03/17 00:00 [revised] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/03/28 06:41 [medline] PHST- 2026/03/28 06:40 [pubmed] PHST- 2026/03/28 01:27 [entrez] PHST- 2026/03/20 00:00 [pmc-release] AID - ijerph23030399 [pii] AID - ijerph-23-00399 [pii] AID - 10.3390/ijerph23030399 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 Mar 20;23(3):399. doi: 10.3390/ijerph23030399. PMID- 41899663 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 23 IP - 3 DP - 2026 Feb 25 TI - Patterns, Predictors, and Mechanisms of Injury in Libyan CrossFit Athletes: A Cross-Sectional Analysis. LID - 10.3390/ijerph23030286 [doi] LID - 286 AB - BACKGROUND: CrossFit is a high-intensity training modality experiencing global growth, but its injury risk profile remains debated. Existing epidemiological studies show a significant geographical bias, with a complete lack of data from North Africa, including Libya. To the best of our knowledge, this study provides the first epidemiological data on CrossFit injuries in Libya, addressing this geographical gap. This study aimed to determine the prevalence, characteristics, and associated risk factors of musculoskeletal injuries among CrossFit athletes in Tripoli, Libya. STUDY DESIGN: This descriptive, cross-sectional study utilized a convenience sample of CrossFit athletes. Data were collected via a self-administered, paper-based questionnaire adapted from validated epidemiological surveys. METHODS: A total of 137 male CrossFit athletes from four affiliated gyms in Tripoli were enrolled. Participants completed a self-administered questionnaire collecting sociodemographic data, training characteristics, and injury history based on a time-loss definition (missing >/=1 training day or seeking medical attention) over a 12-month recall period. Data were analyzed using descriptive statistics. Logistic regression was used to identify injury predictors. RESULTS: The injury prevalence was 40.6%. The shoulder (33.3%) and lumbar spine (25.3%) were the most frequently injured anatomical locations. The primary mechanism of injury was sudden movement (38.6%), and the most common type of injury was tendinopathy (34.5%). The cohort was characterized by relatively young athletes with high training frequency, nearly half of whom had less than six months of training experience. Longer training duration was the only significant independent predictor of injury (OR = 0.136, 95% CI [0.034-0.543] for beginners vs. experienced athletes; p = 0.009), indicating that experienced athletes were at higher risk. CONCLUSIONS: Libyan CrossFit athletes experience high injury rates, with longer training duration-not novice status-predicting injury. These findings underscore the urgent need for standardized coaching and gym affiliation in developing fitness markets to mitigate technique-related injuries and ensure safe sport participation. FAU - Elmahgoub, Sami AU - Elmahgoub S AUID- ORCID: 0000-0003-1337-8435 AD - Department of Physiotherapy, Faculty of Allied Medical Sciences, Applied Science Private University, Amman 11931, Jordan. FAU - Debes, Wesam A AU - Debes WA AD - Department of Physiotherapy, Faculty of Allied Medical Sciences, Applied Science Private University, Amman 11931, Jordan. FAU - El Taguri, Adel AU - El Taguri A AUID- ORCID: 0000-0003-2392-0363 AD - Community Medicine Department, Faculty of Medicine, University of Tripoli, Tripoli 13932, Libya. FAU - Mabrouk, Mohamed I AU - Mabrouk MI AUID- ORCID: 0009-0009-9191-1240 AD - Department of Physiotherapy, Faculty of Allied Medical Sciences, Applied Science Private University, Amman 11931, Jordan. FAU - Melczer, Csaba AU - Melczer C AUID- ORCID: 0000-0002-8197-0572 AD - Institute of Physiotherapy and Sports Science, Faculty of Health Sciences, University of Pecs, H-7621 Pecs, Hungary. FAU - Bekheet, Ahmed B AU - Bekheet AB AD - Department of Physical Therapy for Orthopedic Disorders, El Sahel Teaching Hospital, Cairo 11697, Egypt. FAU - Affan, Ibrahim AU - Affan I AD - Physiotherapy Department, Faculty of Physical Therapy, University of Tripoli, Tripoli 13275, Libya. FAU - Acs, Pongrac AU - Acs P AUID- ORCID: 0000-0002-4999-7345 AD - Physical Activity Research Group, Janos Szentagothai Research Center, University of Pecs, H-7624 Pecs, Hungary. LA - eng PT - Journal Article DEP - 20260225 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - Libya/epidemiology MH - Cross-Sectional Studies MH - Male MH - *Athletic Injuries/epidemiology/etiology MH - Risk Factors MH - *Athletes MH - Prevalence MH - Young Adult MH - Adolescent MH - Adult MH - Surveys and Questionnaires PMC - PMC13026747 OTO - NOTNLM OT - CrossFit OT - Libya OT - injury prevalence OT - musculoskeletal injuries OT - shoulder COIS- The authors declare no conflicts of interest. EDAT- 2026/03/28 06:39 MHDA- 2026/03/28 06:40 PMCR- 2026/02/25 CRDT- 2026/03/28 01:26 PHST- 2026/02/05 00:00 [received] PHST- 2026/02/20 00:00 [revised] PHST- 2026/02/23 00:00 [accepted] PHST- 2026/03/28 06:40 [medline] PHST- 2026/03/28 06:39 [pubmed] PHST- 2026/03/28 01:26 [entrez] PHST- 2026/02/25 00:00 [pmc-release] AID - ijerph23030286 [pii] AID - ijerph-23-00286 [pii] AID - 10.3390/ijerph23030286 [doi] PST - epublish SO - Int J Environ Res Public Health. 2026 Feb 25;23(3):286. doi: 10.3390/ijerph23030286. PMID- 41899237 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260328 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 6 DP - 2026 Mar 18 TI - Identifying Predictors of Lung Volume in Pediatric Patients Undergoing Surgery: A STROBE-Compliant Retrospective Cross-Sectional Chest Computed Tomography Study. LID - 10.3390/jcm15062313 [doi] LID - 2313 AB - Background/Objectives: Tidal volume is determined by height and sex in adults under mechanical ventilation, and it serves as the foundation for implementing a lung-protective ventilation strategy. In children, tidal volume is often calculated based on actual body weight, without established guidelines regarding the predictors of lung volume. The aim of this study was to identify the key predictors of lung volume in children aged 0-5 years. Methods: This retrospective study involved 51 children aged 0-5 years who underwent chest computed tomography (CT) and surgery under general anesthesia between 2014 and 2024. The total lung volume was calculated using three-dimensional segmentation of the CT images. Linear regression models were used to assess predictors, including height, weight, age, sex, and body mass index (BMI). Model performance was evaluated using the adjusted R-squared and Akaike Information Criterion (AIC). Bootstrap validation with 2000 iterations was used to validate model reliability. Results: Height was the strongest predictor of lung volume (adjusted R-squared: 0.5621), and it showed a collinearity with age. The final model included age and sex as the covariates. The Bootstrap validation confirmed the model's reliability. Conclusions: Age and sex are key predictors of the CT-derived total lung volume in children aged 0-5 years. Further studies are required to validate these findings. In addition, research is needed to derive and validate a tidal volume equation based on these predictors and assess the influence of this equation on clinical outcomes such as atelectasis, oxygenation, and inflammatory markers in pediatric surgery. FAU - Lee, Sou-Hyun AU - Lee SH AUID- ORCID: 0000-0002-6785-7688 AD - Department of Anesthesiology and Pain Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 41944, Republic of Korea. FAU - Lim, Dong Gun AU - Lim DG AUID- ORCID: 0000-0002-0976-2576 AD - Department of Anesthesiology and Pain Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 41944, Republic of Korea. FAU - Park, Sung-Sik AU - Park SS AD - Department of Anesthesiology and Pain Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 41944, Republic of Korea. FAU - Jeon, Younghoon AU - Jeon Y AUID- ORCID: 0000-0002-7168-4214 AD - Department of Anesthesiology and Pain Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 41944, Republic of Korea. FAU - Yeo, Jinseok AU - Yeo J AUID- ORCID: 0000-0001-9686-9955 AD - Department of Anesthesiology and Pain Medicine, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu 41404, Republic of Korea. FAU - Jung, Hoon AU - Jung H AD - Department of Anesthesiology and Pain Medicine, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu 41404, Republic of Korea. FAU - Yeom, Jiyong AU - Yeom J AD - Department of Anesthesiology and Pain Medicine, Kyungpook National University Chilgok Hospital, Kyungpook National University School of Medicine, Daegu 41404, Republic of Korea. FAU - Choi, Chanhyo AU - Choi C AUID- ORCID: 0009-0000-4333-9504 AD - Department of Anesthesiology and Pain Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 41944, Republic of Korea. FAU - Kwak, Kyung-Hwa AU - Kwak KH AD - Department of Anesthesiology and Pain Medicine, Kyungpook National University Hospital, Kyungpook National University School of Medicine, Daegu 41944, Republic of Korea. LA - eng PT - Journal Article DEP - 20260318 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC13027331 OTO - NOTNLM OT - computed tomography OT - linear model OT - pediatrics OT - respiratory physiological phenomena OT - total lung capacity COIS- The authors declare no conflicts of interest. EDAT- 2026/03/28 06:40 MHDA- 2026/03/28 06:41 PMCR- 2026/03/18 CRDT- 2026/03/28 01:25 PHST- 2026/02/05 00:00 [received] PHST- 2026/03/04 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/03/28 06:41 [medline] PHST- 2026/03/28 06:40 [pubmed] PHST- 2026/03/28 01:25 [entrez] PHST- 2026/03/18 00:00 [pmc-release] AID - jcm15062313 [pii] AID - jcm-15-02313 [pii] AID - 10.3390/jcm15062313 [doi] PST - epublish SO - J Clin Med. 2026 Mar 18;15(6):2313. doi: 10.3390/jcm15062313. PMID- 41898801 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 2073-4425 (Electronic) IS - 2073-4425 (Linking) VI - 17 IP - 3 DP - 2026 Feb 26 TI - Diagnosis of Familial Hypercholesterolemia in Children: From Clinical Features Through Gene Variants to Polygenic Score. LID - 10.3390/genes17030267 [doi] LID - 267 AB - BACKGROUND: Early diagnosis of familial hypercholesterolemia (FH) is crucial to improve long-term outcomes. FH diagnosis relies on elevated low-density lipoprotein cholesterol (LDL-C) levels, familial clinical characteristics, and identification of pathogenic variants in FH-related genes. Secondary factors, such as overweight and obesity, are known to influence lipid profiles in the general population. More recently, polygenic risk scores based on single-nucleotide polymorphisms (SNPs) have been proposed as additional determinants of LDL-C levels. METHODS: We enrolled 214 pediatric subjects with LDL-C levels >/=95th percentile (after 6 months of dietary intervention) and with at least one parent with LDL-C levels >/= 95th percentile. All participants underwent biochemical and auxological assessment and genetic testing for FH. In a subgroup of 60 subjects, LDL-C polygenic scores based on 6- and 12-SNPs were calculated. RESULTS: Pathogenic variants confirming heterozygous FH were identified in 190 subjects (variant-positive, V+); 17 were variant-negative (V-), yielding a mutation detection rate of 91.8%. An additional seven patients carrying variants of uncertain significance were excluded from the primary analysis. LDL-C was modestly higher in V+ than V- subjects using both Friedewald (212 vs. 188 mg/dL; p = 0.035) and Martin-Hopkins formulas (208 vs. 187 mg/dL; p = 0.041), while the other main clinical and laboratory parameters were similar. In V+, LDL-C was higher in subjects with null variants, compared to those with defective variants. Body mass index (BMI SDS) was inversely correlated with HDL-C (p < 0.001), and obesity (BMI z-score > 2 SDS) was associated with lower HDL-C and higher LDL-C, non-HDL-C, and ApoB. With regard to the polygenic scores, 12- and 6-SNP scores showed overlap between V+ and V-, and published cut-offs did not discriminate lipid severity in our population; however, in V+ subjects, the 12-SNP score acted as a phenotype modifier, being independently associated with higher LDL-C and non-HDL-C levels after adjustment for age, sex, and BMI SDS. CONCLUSIONS: In children selected by LDL-C >/= 95th percentile, together with autosomal dominant familial hypercholesterolemia, genetic confirmation of FH is achieved in the vast majority of cases. Variant type (null vs. defective), BMI, and polygenic background contribute to phenotypic heterogeneity, supporting the need to address other factors alongside genetic diagnosis. Further validation is needed before polygenic scores can be implemented in routine clinical practice. FAU - Buganza, Raffaele AU - Buganza R AUID- ORCID: 0000-0003-1850-2300 AD - Department of Public Health and Pediatric Sciences, University of Turin, Regina Margherita Children's Hospital, 10126 Turin, Italy. FAU - Nobili, Cecilia AU - Nobili C AUID- ORCID: 0009-0001-5112-8982 AD - Department of Public Health and Pediatric Sciences, University of Turin, Regina Margherita Children's Hospital, 10126 Turin, Italy. FAU - Massini, Giulia AU - Massini G AD - Department of Public Health and Pediatric Sciences, University of Turin, Regina Margherita Children's Hospital, 10126 Turin, Italy. FAU - Cardiero, Giovanna AU - Cardiero G AD - Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, 80131 Naples, Italy. AD - CEINGE-Biotecnologie Avanzate Franco Salvatore, 80145 Naples, Italy. FAU - Di Taranto, Maria Donata AU - Di Taranto MD AUID- ORCID: 0000-0002-0618-7940 AD - Dipartimento di Medicina Molecolare e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, 80131 Naples, Italy. AD - CEINGE-Biotecnologie Avanzate Franco Salvatore, 80145 Naples, Italy. FAU - de Sanctis, Luisa AU - de Sanctis L AD - Department of Public Health and Pediatric Sciences, University of Turin, Regina Margherita Children's Hospital, 10126 Turin, Italy. FAU - Guardamagna, Ornella AU - Guardamagna O AUID- ORCID: 0000-0003-3137-5916 AD - Department of Public Health and Pediatric Sciences, University of Turin, Regina Margherita Children's Hospital, 10126 Turin, Italy. LA - eng PT - Journal Article DEP - 20260226 PL - Switzerland TA - Genes (Basel) JT - Genes JID - 101551097 RN - 0 (Cholesterol, LDL) SB - IM MH - Humans MH - *Hyperlipoproteinemia Type II/genetics/diagnosis/blood MH - Female MH - Child MH - Male MH - Genetic Risk Score MH - Cholesterol, LDL/blood/genetics MH - *Polymorphism, Single Nucleotide MH - *Multifactorial Inheritance MH - Adolescent PMC - PMC13025718 OTO - NOTNLM OT - BMI OT - children OT - familial hypercholesterolemia OT - gene variants OT - polygenic score COIS- The authors declare no conflicts of interest. EDAT- 2026/03/28 06:39 MHDA- 2026/03/28 06:40 PMCR- 2026/02/26 CRDT- 2026/03/28 01:23 PHST- 2026/01/14 00:00 [received] PHST- 2026/02/06 00:00 [revised] PHST- 2026/02/14 00:00 [accepted] PHST- 2026/03/28 06:40 [medline] PHST- 2026/03/28 06:39 [pubmed] PHST- 2026/03/28 01:23 [entrez] PHST- 2026/02/26 00:00 [pmc-release] AID - genes17030267 [pii] AID - genes-17-00267 [pii] AID - 10.3390/genes17030267 [doi] PST - epublish SO - Genes (Basel). 2026 Feb 26;17(3):267. doi: 10.3390/genes17030267. PMID- 41897217 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260328 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 6 DP - 2026 Mar 18 TI - Mediterranean Diet Adherence, Physical Activity, and Motivation Toward Physical Education in Adolescent Girls: A Cross-Sectional Study. LID - 10.3390/healthcare14060764 [doi] LID - 764 AB - Background: Adolescence represents a critical period for the adoption of lifestyle behaviors that may influence physical health, emotional well-being, and health-related behaviors later in life. However, limited evidence exists regarding the combined association of dietary habits and physical activity with motivation toward physical education, particularly among adolescent girls from different residential environments. Objective: This study aimed to examine the relationship between adherence to the Mediterranean diet, physical activity levels, and motivation toward physical education among adolescent girls from urban and rural settings. Methods: A cross-sectional study was carried out involving girls aged 12 to 14 years (n = 217; N(Urban) = 108 and N(Rural) = 109). Adherence to the Mediterranean diet, physical activity levels, and motivational dimensions toward PE were assessed using validated questionnaires. Differences between groups were analyzed using analysis of variance (ANOVA), and an analysis of covariance (ANCOVA) was performed controlling for physical activity levels. Effect sizes were calculated using partial eta squared (eta(2)p). Results: Significant differences were observed in intrinsic motivation, identified regulation, introjected regulation, and amotivation according to adherence to the Mediterranean diet (p < 0.05), with small to moderate effect sizes (eta(2)p = 0.029-0.040). Post hoc analyses indicated that girls with optimal adherence to the Mediterranean diet exhibited higher intrinsic motivation toward PE compared with those with low adherence. The ANCOVA revealed that higher physical activity levels were significantly associated with greater intrinsic motivation, particularly among girls from urban environments. No significant differences were found between urban and rural environments in overall physical activity levels or dietary adherence. Conclusions: Greater adherence to the Mediterranean diet and higher levels of physical activity are associated with more self-determined motivational profiles toward physical education in adolescent girls. These findings highlight the importance of integrated school-based interventions that promote healthy eating and active lifestyles to enhance motivation and engagement in PE among adolescent girls. FAU - San Martin Gonzalez, Paula AU - San Martin Gonzalez P AUID- ORCID: 0000-0001-6783-1376 AD - Department of Nursing, Faculty of Health Sciences, Pontifical University of Salamanca, 37002 Salamanca, Spain. FAU - Hermida Carballido, Natalia AU - Hermida Carballido N AD - Department of Health Sciences, Faculty of Health Sciences, University of Burgos, 09001 Burgos, Spain. FAU - Maneiro Dios, Ruben AU - Maneiro Dios R AUID- ORCID: 0000-0002-2215-9720 AD - Department of Special Didactics, Faculty of Education and Sports Sciences, University of Vigo, 36005 Pontevedra, Spain. FAU - Arroyo Del Bosque, Ruben AU - Arroyo Del Bosque R AUID- ORCID: 0000-0002-2460-2140 AD - Department of Specific Didactics, Faculty of Education, University of Burgos, 09001 Burgos, Spain. LA - eng PT - Journal Article DEP - 20260318 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13026701 OTO - NOTNLM OT - Mediterranean diet OT - adolescent girls OT - health promotion OT - healthy lifestyle behaviours OT - school health programs OT - self-determination theory COIS- The authors declare no conflicts of interest. EDAT- 2026/03/28 06:39 MHDA- 2026/03/28 06:40 PMCR- 2026/03/18 CRDT- 2026/03/28 01:17 PHST- 2026/02/02 00:00 [received] PHST- 2026/03/12 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/03/28 06:40 [medline] PHST- 2026/03/28 06:39 [pubmed] PHST- 2026/03/28 01:17 [entrez] PHST- 2026/03/18 00:00 [pmc-release] AID - healthcare14060764 [pii] AID - healthcare-14-00764 [pii] AID - 10.3390/healthcare14060764 [doi] PST - epublish SO - Healthcare (Basel). 2026 Mar 18;14(6):764. doi: 10.3390/healthcare14060764. PMID- 41897212 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260328 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 6 DP - 2026 Mar 18 TI - Back Muscle Strength Is Associated with Self-Reported Morning-Erection Frequency in Apparently Healthy Japanese Male University Students: A Cross-Sectional Study. LID - 10.3390/healthcare14060759 [doi] LID - 759 AB - Background/Objectives: Morning erections provide an intercourse-independent indicator of nocturnal erectile physiology. We aimed to examine whether body mass index (BMI) and muscle strength are associated with morning-erection frequency in apparently healthy Japanese male university students. Methods: This cross-sectional study analyzed 125 men with complete data (170 assessed; 45 excluded). Handgrip and back muscle strength were measured using dynamometry; BMI was calculated from height and weight. Morning-erection frequency was assessed using a single 6-category item and was dichotomized as low vs. high. Univariable and multivariable logistic regression models were fitted. Exploratory principal component analysis (PCA) and k-means clustering (k = 2, silhouette-supported) were performed. Results: Seventy-four participants (59.2%) were classified as low frequency. Back muscle strength was associated with high frequency (univariable odds ratio [OR] 1.61; 95% confidence interval [CI] 1.07-2.42; and p = 0.021) and remained significant after adjustment for BMI and handgrip strength (OR 1.88; 95% CI 1.02-3.47; and p = 0.045), whereas BMI and handgrip strength were not significant. Clustering identified two clusters (n = 41 and n = 84); Cluster 2 (higher BMI/strength) had a higher proportion of high morning-erection frequency (48% vs. 27%). Conclusions: In apparently healthy young men, greater back muscle strength was independently associated with higher self-reported morning-erection frequency. In this cohort, 59.2% reported infrequent morning erections, suggesting potential relevance even in early adulthood. Given the exploratory clustering, the single-item outcome, and likely residual confounding, these findings are hypothesis-generating and warrant longitudinal validation. FAU - Endo, Yoshiaki AU - Endo Y AUID- ORCID: 0000-0002-5582-343X AD - Department of Physical Therapy, School of Health Science, International University of Health and Welfare, 2600-1 Kitakanemaru, Otawara 324-8501, Tochigi, Japan. FAU - Tanaka, Takazo AU - Tanaka T AUID- ORCID: 0000-0002-0370-0323 AD - Department of Urology, Tsukuba Gakuen Hospital, 2573-1 Kamiyokoba, Tsukuba 305-0854, Ibaraki, Japan. FAU - Kojo, Kosuke AU - Kojo K AUID- ORCID: 0000-0002-6875-0874 AD - Department of Urology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Ibaraki, Japan. AD - Tsukuba Clinical Research & Development Organization (T-CReDO), University of Tsukuba, 2-1-1 Amakubo, Tsukuba 305-8576, Ibaraki, Japan. AD - Center for Human Reproduction, International University of Health and Welfare Hospital, 537-3 Iguchi, Nasushiobara 329-2763, Tochigi, Japan. FAU - Matsumoto, Chiaki AU - Matsumoto C AUID- ORCID: 0009-0007-1332-3633 AD - Department of Physical Therapy, School of Health Science, International University of Health and Welfare, 2600-1 Kitakanemaru, Otawara 324-8501, Tochigi, Japan. FAU - Kurobe, Masahiro AU - Kurobe M AUID- ORCID: 0000-0002-5819-523X AD - Center for Human Reproduction, International University of Health and Welfare Hospital, 537-3 Iguchi, Nasushiobara 329-2763, Tochigi, Japan. AD - Department of Systems Physiology, Graduate School of Medicine, University of the Ryukyus, 1076 Kiyuna, Ginowan 901-2720, Okinawa, Japan. FAU - Nishiyama, Hiroyuki AU - Nishiyama H AUID- ORCID: 0000-0001-7423-596X AD - Department of Urology, Institute of Medicine, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Ibaraki, Japan. FAU - Takayama, Tatsuya AU - Takayama T AUID- ORCID: 0000-0003-3360-7688 AD - Center for Human Reproduction, International University of Health and Welfare Hospital, 537-3 Iguchi, Nasushiobara 329-2763, Tochigi, Japan. AD - Department of Urology, School of Medicine, International University of Health and Welfare, 4-3 Kozunomori, Narita 286-8686, Chiba, Japan. FAU - Miyazaki, Jun AU - Miyazaki J AUID- ORCID: 0000-0002-3618-0432 AD - Department of Urology, School of Medicine, International University of Health and Welfare, 4-3 Kozunomori, Narita 286-8686, Chiba, Japan. LA - eng GR - JPMJPF2017/Japan Science and Technology Agency/ PT - Journal Article DEP - 20260318 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC13027116 OTO - NOTNLM OT - adolescent and young adult OT - body composition OT - erectile dysfunction OT - health behavior OT - lifestyle factors OT - muscle strength OT - nocturnal penile tumescence OT - reproductive health OT - sexual function OT - trunk muscles COIS- The authors declare no conflicts of interest. EDAT- 2026/03/28 06:39 MHDA- 2026/03/28 06:40 PMCR- 2026/03/18 CRDT- 2026/03/28 01:17 PHST- 2026/01/28 00:00 [received] PHST- 2026/03/13 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/03/28 06:40 [medline] PHST- 2026/03/28 06:39 [pubmed] PHST- 2026/03/28 01:17 [entrez] PHST- 2026/03/18 00:00 [pmc-release] AID - healthcare14060759 [pii] AID - healthcare-14-00759 [pii] AID - 10.3390/healthcare14060759 [doi] PST - epublish SO - Healthcare (Basel). 2026 Mar 18;14(6):759. doi: 10.3390/healthcare14060759. PMID- 41897117 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260328 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 3 DP - 2026 Mar 14 TI - Measuring Digital Stress in Children: Construct Validity, Model Comparisons, and Measurement Invariance of a Multidimensional Scale (DSS-CH). LID - 10.3390/children13030405 [doi] LID - 405 AB - Background: The use of digital media in childhood offers both opportunities and risks. Digital stressors-such as excessive screen time, constant availability, information overload, and social media pressures-affect primary school children but have been rarely studied systematically. Despite growing research, no validated instruments adequately capture how younger children perceive and express digital stress. This study presents the development and validation of a three-dimensional instrument for children under 14: the "Digital Stress in Children" scale (DSS-CH). The DSS-CH is theory-driven and child-appropriate, with three interrelated but distinct dimensions: (1) excessive screen time, (2) compulsive media behavior, and (3) approval anxiety. Methods: In a cross-sectional survey of n = 907 Swiss primary school children (grades 5-6; ages 10-14), participants completed an online questionnaire in class. Latent variable modeling with cluster-robust inference accounted for classroom nesting. Competing models (1-, 2-, 3-factor CFA; ESEM; bifactor-ESEM) were evaluated. Results: The 1-factor CFA fit poorly (CFI approximately 0.81; RMSEA approximately 0.15), while the 3-factor CFA showed acceptable fit (CFI approximately 0.96; RMSEA approximately 0.07). Allowing cross-loadings improved fit substantially in the 3-factor ESEM and bifactor-ESEM (CFI approximately 0.999; RMSEA approximately 0.01), supporting a general digital stress factor alongside facet-specific variance. Subscales showed good reliability (ordinal alpha approximately 0.81 - 0.89) and moderate intercorrelations (r approximately 0.28 - 0.47). Scalar invariance across gender and age was supported (DeltaCFI /= 0.50 for 12 of 14 nutrients, and misclassification into opposite tertiles (> 10% of participants) was observed only for SFAs (13%). Bland-Altman analysis confirmed acceptable agreement for energy and macronutrient intakes. At the food group level, the eFFQ yielded significantly higher median intakes for 14 of 28 food groups - most notably plant-based protein-rich foods and cream, fatty sauces & other fats - and lower median intakes for four groups, including vegetables and fish. Ranking agreement was acceptable for most food groups (SCCs = 0.57-0.91) but weaker for water (0.07); vegetable oil (0.42); cream, fatty sauces & other fats (0.33); and mixed dishes & soups (0.47). CONCLUSIONS: The new eFFQ demonstrated good relative agreement with the previous paper-based FFQ, particularly for ranking individuals. These findings provide valuable information for researchers and policy makers comparing results of both FFQs over time and across populations. FAU - Chatelan, Angeline AU - Chatelan A AD - Department of Nutrition and Dietetics, Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Rue des Caroubiers 25, Carouge-Geneva, 1227, Switzerland. angeline.chatelan@hesge.ch. FAU - Chevillard, Elsa AU - Chevillard E AD - Department of Nutrition and Dietetics, Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Rue des Caroubiers 25, Carouge-Geneva, 1227, Switzerland. FAU - Pannen, Sarah T AU - Pannen ST AD - Division of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland. AD - Swiss School of Public Health, Zurich, Switzerland. FAU - Hillesheim, Elaine AU - Hillesheim E AD - Department of Nutrition and Dietetics, Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Rue des Caroubiers 25, Carouge-Geneva, 1227, Switzerland. FAU - Stringhini, Silvia AU - Stringhini S AD - Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. AD - Faculty of Medicine, University of Geneva, Geneva, Switzerland. AD - School of Population and Public Health and Edwin S.H. Leong Centre for Healthy Aging, Faculty of Medicine, University of British Columbia, Vancouver, Canada. FAU - Nehme, Mayssam AU - Nehme M AD - Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. AD - Faculty of Medicine, University of Geneva, Geneva, Switzerland. FAU - Guessous, Idris AU - Guessous I AD - Division of Primary Care Medicine, Geneva University Hospitals, Geneva, Switzerland. AD - Faculty of Medicine, University of Geneva, Geneva, Switzerland. FAU - Rohrmann, Sabine AU - Rohrmann S AD - Division of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland. AD - Swiss School of Public Health, Zurich, Switzerland. FAU - Steinemann, Nina AU - Steinemann N AD - Division of Chronic Disease Epidemiology, Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland. FAU - Sych, Janice AU - Sych J AD - Institute of Food and Beverage Innovation, ZHAW School of Life Sciences and Facility Management, Wadenswil, Switzerland. FAU - Marques-Vidal, Pedro AU - Marques-Vidal P AD - Department of Medicine, Internal Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. LA - eng GR - 13-M22/Research and Impulse Funds (FRI)/ PT - Journal Article DEP - 20260327 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 RN - 0 (Micronutrients) RN - 0 (Dietary Fats) SB - IM MH - Humans MH - Switzerland MH - Female MH - Middle Aged MH - Adult MH - Male MH - Aged MH - *Internet MH - Adolescent MH - Young Adult MH - *Diet Surveys/methods MH - Surveys and Questionnaires MH - Energy Intake MH - *Diet MH - Nutrition Assessment MH - Reproducibility of Results MH - Micronutrients/administration & dosage MH - Diet Records MH - Dietary Fats/administration & dosage PMC - PMC13147631 OTO - NOTNLM OT - Diet OT - Dietary assessment OT - Digital health OT - Epidemiology OT - Food frequency questionnaire OT - Internet OT - Validation study COIS- Declarations. Ethics approval and consent to participate: This study was conducted according to the guidelines laid down in the Declaration of Helsinki. The study was reviewed by the Ethics Committee of the Canton of Zurich, which determined that formal ethical approval was not required (Req-2022-01268, same request as for the validation study of the eFFQ by Pannen et al.). All participants signed an electronic informed consent detailing the study protocol, objectives and data management procedures. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/28 06:39 MHDA- 2026/06/27 18:38 PMCR- 2026/03/27 CRDT- 2026/03/28 01:07 PHST- 2025/11/05 00:00 [received] PHST- 2026/03/08 00:00 [accepted] PHST- 2026/06/27 18:38 [medline] PHST- 2026/03/28 06:39 [pubmed] PHST- 2026/03/28 01:07 [entrez] PHST- 2026/03/27 00:00 [pmc-release] AID - 10.1186/s12937-026-01309-7 [pii] AID - 1309 [pii] AID - 10.1186/s12937-026-01309-7 [doi] PST - epublish SO - Nutr J. 2026 Mar 27;25(1):59. doi: 10.1186/s12937-026-01309-7. PMID- 41896893 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1472-6963 (Electronic) IS - 1472-6963 (Linking) VI - 26 IP - 1 DP - 2026 Mar 27 TI - The development of a video-based intervention (V-BIS) to improve the interpersonal communication skills of public health midwives. LID - 10.1186/s12913-026-14291-x [doi] LID - 648 AB - BACKGROUND: Interpersonal Communication Skills (IPCS), specific verbal and non-verbal skills, have been identified as core skills for effective interpersonal communication. The IPCS are essential clinical skills for Public Health Midwives (PHMs), front-line public healthcare providers for maternal and childcare, in Sri Lanka. These PHMs showed low levels of IPCS, and traditional training methods have failed to translate theoretical knowledge of IPCS into practice. This study proposes a novel video-based intervention with skill improvement sessions (V-IBS) designed to bridge the gap in communication skill training for healthcare providers. METHODS: The development of the V-BIS intervention incorporates a three-phase approach: theoretical review, modeling, and piloting. Initially, a comprehensive literature review and targeted training needs assessment through focus group discussions and direct observation using simulated clients were conducted to identify key IPCS areas for development. This foundation informed the creation of educational videos and role-play exercises tailored to address specific IPCS gaps of PHMs. PHMs and administrators in the study evaluated the intervention to determine its feasibility and effectiveness. RESULTS: The V-BIS intervention is a half-day training program that includes educational videos on IPCS, peer role-playing, and a constructive discussion after analyzing the video-recorded role-plays by peers. All PHMs and their local managers in the study agreed that the intervention was comprehensive and feasible to implement in the work setting of PHMs. CONCLUSION: The V-BIS intervention is a feasible video-based intervention to improve the IPCS of PHMs. TRIAL REGISTRATION: Clinical Trial Registry, Sri Lanka. Ref No, SLCTR/2020/006(Feb 4th,2020). FAU - Prasanna, S A S AU - Prasanna SAS AD - Ministry of Health, Colombo, Sri Lanka. samithaprasanna33@gmail.com. FAU - Abeysena, H T C S AU - Abeysena HTCS AD - Department of Community Medicine, Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka. FAU - Alagiyawanna, M A A P AU - Alagiyawanna MAAP AD - Health Promotion Bureau, Ministry of Health, Colombo, Sri Lanka. LA - eng PT - Journal Article DEP - 20260327 PL - England TA - BMC Health Serv Res JT - BMC health services research JID - 101088677 SB - IM MH - Humans MH - *Communication MH - Female MH - Sri Lanka MH - *Midwifery/education MH - *Video Recording MH - Focus Groups MH - Clinical Competence MH - *Interpersonal Relations PMC - PMC13151309 OTO - NOTNLM OT - Communication skill OT - Interpersonal OT - Training OT - Video Intervention COIS- Declarations. Ethics approval and consent to participate: .Ethical clearance for the study was approved by the Ethics Review Committee of the Faculty of Medicine, University of Kelaniya, Ragama, Sri Lanka (Ref. no p/230/09/2017). This study was performed in accordance with Helsinki's declaration. Informed written consent was obtained from all study participants. We have also registered this study in the Sri Lanka Clinical Trials Registry, Sri Lanka Medical Association, 06, Wijerama House, Wijerama Mawatha, Colombo 08 (Reg. no - SLCTR/2020/006). Consent for publication: Consent for publication was taken in writing. Competing interests: The authors declare no competing interests. EDAT- 2026/03/28 06:40 MHDA- 2026/06/27 12:37 PMCR- 2026/03/27 CRDT- 2026/03/28 01:07 PHST- 2023/06/21 00:00 [received] PHST- 2026/02/26 00:00 [accepted] PHST- 2026/06/27 12:37 [medline] PHST- 2026/03/28 06:40 [pubmed] PHST- 2026/03/28 01:07 [entrez] PHST- 2026/03/27 00:00 [pmc-release] AID - 10.1186/s12913-026-14291-x [pii] AID - 14291 [pii] AID - 10.1186/s12913-026-14291-x [doi] PST - epublish SO - BMC Health Serv Res. 2026 Mar 27;26(1):648. doi: 10.1186/s12913-026-14291-x. PMID- 41896616 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260520 LR - 20260813 IS - 2730-664X (Electronic) IS - 2730-664X (Linking) VI - 6 IP - 1 DP - 2026 Mar 27 TI - Gestational weight gain and adverse perinatal outcomes among individuals with gestational diabetes. LID - 10.1038/s43856-026-01544-3 [doi] LID - 292 AB - BACKGROUND: The relationship between gestational weight gain and perinatal outcomes in women with gestational diabetes remains inadequately studied, and specific weight gain recommendations are lacking for this population. METHODS: We conducted a retrospective cross-sectional study by extracting natality data from the National Center for Health Statistics (NCHS) of the Centers for Disease Control and Prevention in the United States, including 1,368,789 record (2015-2020) as the main sample and 280,165 (2021) as the validation sample. The composite adverse outcome is defined as a composite of gestational hypertension or preeclampsia, primary cesarean delivery, maternal transfusion, maternal intensive care admission, preterm birth<37 weeks, small or large size for gestational age at birth and neonatal intensive care unit admission. Optimal gestational weight gain ranges were estimated for each pre-pregnancy body mass index category through multivariable logistic regression model to identify the odds ratio targets at which any adverse outcome decreased. Model discrimination was evaluated using area under the receiver operating characteristic curve. RESULTS: Adverse outcomes occur in 52.67% of pregnancies, with incidence rising substantially with body mass index (44.28% in normal weight vs 67.08% in class 3 obesity). The optimal gestational weight gain ranges are: underweight (12.0- < 20.0 kg), normal weight (8.0- < 16.0 kg), overweight (weight loss-<14 kg), class 1 obesity (weight loss-<10.0 kg) and obesity classes 2-3 (weight loss <8.0 kg). These ranges demonstrate low to moderate discrimination between affected and unaffected pregnancies (ranges of area under the receiver operating characteristic curve, 0.57-0.68). CONCLUSIONS: Minimal weight gain or weight loss is associated with a decreased risk of adverse perinatal outcomes among women with overweight or obesity complicated by gestational diabetes. CI - (c) 2026. The Author(s). FAU - Zhao, Xiao Bo AU - Zhao XB AD - Department of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, P.R. China. FAU - Su, Xiu Juan AU - Su XJ AD - Clinic Research Center, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, P.R. China. FAU - Qi, Xun AU - Qi X AD - Department of hepatology, Shanghai public health clinical center, Shanghai, P.R. China. FAU - Ma, Ying Xuan AU - Ma YX AD - Department of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, P.R. China. FAU - Mol, Ben William AU - Mol BW AD - Department of Obstetrics and Gynecology, Monash University, Monash Medical Centre, Clayton, Victoria, Australia. AD - Aberdeen Centre for Women's Health Research, School of Medicine, Medical Sciences and Nutrition, University of Aberdeen, Aberdeen, United Kingdom. FAU - Liu, Xiao Hua AU - Liu XH AUID- ORCID: 0000-0003-2509-9214 AD - Department of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, P.R. China. annaabcd114@hotmail.com. FAU - Ying, Hao AU - Ying H AUID- ORCID: 0000-0002-6098-7017 AD - Department of Obstetrics, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, P.R. China. stephenying_2011@163.com. LA - eng PT - Journal Article DEP - 20260327 PL - England TA - Commun Med (Lond) JT - Communications medicine JID - 9918250414506676 PMC - PMC13187155 OAB - Current pregnancy weight gain guidelines are not specific for women with gestational diabetes, who face high risks during childbirth. This study analyzed U.S. data from over 1.3 million pregnancies complicated by gestational diabetes to determine the optimal weight gain ranges based on pre-pregnancy body mass index. We found that for women with obesity and gestational diabetes, lower weight gain or even weight loss is associated with the lowest risk of pregnancy complications. Pre-pregnancy weight was a stronger predictor for the risk of complications than weight gain during pregnancy. These results suggest that more specific weight management guidance for women with obesity might be helpful for improvement in pregnancy outcomes for both mother and baby. OABL- eng COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/03/28 06:40 MHDA- 2026/03/28 06:41 PMCR- 2026/03/27 CRDT- 2026/03/28 00:35 PHST- 2025/06/19 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/03/28 06:41 [medline] PHST- 2026/03/28 06:40 [pubmed] PHST- 2026/03/28 00:35 [entrez] PHST- 2026/03/27 00:00 [pmc-release] AID - 10.1038/s43856-026-01544-3 [pii] AID - 1544 [pii] AID - 10.1038/s43856-026-01544-3 [doi] PST - epublish SO - Commun Med (Lond). 2026 Mar 27;6(1):292. doi: 10.1038/s43856-026-01544-3. PMID- 41895835 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 1440-6047 (Electronic) IS - 0964-7058 (Print) IS - 0964-7058 (Linking) VI - 35 IP - 2 DP - 2026 Apr TI - Diet quality of Japanese preschool children assessed by the Healthy Eating Index-2020: Nutrient and food group intake, as well as weekday-weekend differences. PG - 281-327 LID - 10.6133/apjcn.202604_35(2).0010 [doi] AB - BACKGROUND AND OBJECTIVES: In Japan, there are no official dietary guidelines for young children and nutrients may be insufficient on weekends, compared to weekdays at nursery schools. To ensure adequate nutrition, an appropriate dietary evaluation method is required. This study used the Healthy Eating Index (HEI)-2020, which is based on the Dietary Guidelines for Americans, to evaluate the diet quality of Japanese children, examine its validity through associations with nutrient and food group intake, and compare dietary characteristics on weekdays and weekends. METHODS AND STUDY DESIGN: The participants were 669 children aged 3 to 5 years attending nursery schools across Japan. Relationships of HEI-2020 scores with nutrient and food group intake, and comparisons between weekdays and weekends were evaluated. RESULTS: The median HEI-2020 score was 50/100, with almost maximum scores for Total Protein Foods, Seafood and Plant Pro-teins, and Added Sugars, while Whole Grains and Refined Grains scored zero. Additionally, the largest score differences between weekdays and weekends were found in Dairy and Greens and Beans. Higher HEI-2020 scores correlated with lower saturated fatty acids intake and higher intakes of dietary fiber, vitamins, and minerals. Weekday scores were significantly higher and less varied than weekend scores. CONCLUSIONS: HEI-2020 can identify nutrient intake challenges in Japanese children. Greater consumption of Dairy and Greens and Beans-components that showed large weekday-weekend differences-may improve diet quality. FAU - Akazawa, Hazuki AU - Akazawa H AD - Graduate School of Human Life and Ecology, Osaka Metropolitan University, Osaka, Osaka, Japan. Email: hazuki.akazawa@nissin.com. AD - NISSIN Global Food Safety Institute, NISSIN FOODS HOLDINGS CO., LTD, Hachioji, Tokyo, Japan. AD - National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health, and Nutrition, Settsu, Osaka, Japan. FAU - Sakai, Atsuki AU - Sakai A AD - Graduate School of Human Life and Ecology, Osaka Metropolitan University, Osaka, Osaka, Japan. FAU - Takahashi, Takako AU - Takahashi T AD - Graduate School of Human Life and Ecology, Osaka Metropolitan University, Osaka, Osaka, Japan. FAU - Okabe, Tetsuko AU - Okabe T AD - School of Nursing and Nutrition, Tenshi College, Sapporo, Hokkaido, Japan. FAU - Sasaki, Ruriko AU - Sasaki R AD - Faculty of Human Life Science, Miyagi Gakuin Women's University, Sendai, Miyagi, Japan. FAU - Ishida, Hiromi AU - Ishida H AD - Faculty of Nutrition, Kagawa Nutrition University, Sakado, Saitama, Japan. FAU - Ogata, Hiromitsu AU - Ogata H AD - Faculty of Nutrition, Kagawa Nutrition University, Sakado, Saitama, Japan. FAU - Hara, Mitsuhiko AU - Hara M AD - Faculty of Human Ecology, Wayo Women's University, Ichikawa, Chiba, Japan. FAU - Yoshioka, Yukiko AU - Yoshioka Y AD - Faculty of Nutritional Science, Sagami Women's University, Sagamihara, Kanagawa, Japan. FAU - Nozue, Miho AU - Nozue M AD - Faculty of Health Promotional Sciences, Tokoha University, Hamamatsu, Shizuoka, Japan. FAU - Sakamoto, Tatsuaki AU - Sakamoto T AD - Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Kumamoto, Kumamo-to, Japan. FAU - Ito, Sanae AU - Ito S AD - Faculty of Medicine, University of the Ryukyus, Ginowan, Okinawa, Japan. FAU - Murayama, Nobuko AU - Murayama N AD - Faculty of Human Life Studies, University of Niigata Prefecture, Niigata, Niigata, Japan. FAU - Yoshita, Katsushi AU - Yoshita K AD - Graduate School of Human Life and Ecology, Osaka Metropolitan University, Osaka, Osaka, Japan. LA - eng PT - Journal Article PL - China TA - Asia Pac J Clin Nutr JT - Asia Pacific journal of clinical nutrition JID - 9440304 RN - Japanese people SB - IM MH - Humans MH - Japan MH - Child, Preschool MH - *Diet, Healthy/statistics & numerical data MH - Female MH - Male MH - *Nutrients MH - *Diet/statistics & numerical data MH - Nutrition Policy MH - Nutrition Assessment MH - Nutritive Value MH - *Diet Surveys MH - Child Nutritional Physiological Phenomena MH - East Asian People PMC - PMC13012830 OTO - NOTNLM OT - child nutrition OT - diet quality OT - dietary evaluation OT - nutrient profiling system OT - weekdays vs weekends COIS- HA declares that she is employed by NISSIN FOODS HOLDINGS CO., LTD. and has no competing interests. The other authors declare that they have no competing interests EDAT- 2026/03/28 00:42 MHDA- 2026/03/28 00:43 PMCR- 2026/03/17 CRDT- 2026/03/27 21:32 PHST- 2026/03/28 00:43 [medline] PHST- 2026/03/28 00:42 [pubmed] PHST- 2026/03/27 21:32 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - 10.6133/apjcn.202604_35(2).0010 [doi] PST - ppublish SO - Asia Pac J Clin Nutr. 2026 Apr;35(2):281-327. doi: 10.6133/apjcn.202604_35(2).0010. PMID- 41895828 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 1440-6047 (Electronic) IS - 0964-7058 (Print) IS - 0964-7058 (Linking) VI - 35 IP - 2 DP - 2026 Apr TI - Association between the frequency of combined staple, main, and side dishes and nutritional adequacy among young Japanese women: A cross-sectional study. PG - 197-206 LID - 10.6133/apjcn.202604_35(2).0003 [doi] AB - BACKGROUND AND OBJECTIVES: Traditional Japanese diet comprises staple food, main dish, and side dish (SMS). Studies reporting the association between the frequency of SMS meals consumption and nutritional adequacy remain limited. We aimed to examine the association between the frequency of SMS meals consumption and nutritional adequacy in young Japanese women. METHODS AND STUDY DESIGN: In this cross-sectional study, data from 329 female nutrition students aged 18-25 years were analysed. The frequency of SMS meals consumption more than twice a day was assessed using a self-administered questionnaire, and dietary intake was evaluated using a validated food frequency questionnaire. We examined the association between SMS meals consumption and likelihood of not meeting the Dietary Goal (DG) or the Estimated Average Requirement (EAR) as defined in the Japanese Dietary Reference Intakes for Japanese. Trend analyses were performed to evaluate the relationship between SMS meal frequency and the number of nutrients not meeting the DG or EAR, while adjusting for potential confounders. RESULTS: Participants with high frequency of SMS meals consumption (5-7 days/week) had the lowest number of nutrients not meeting the EAR and DG, with significant linear trends observed across categories (p for trend <0.001 for DG; 0.001 for EAR). CONCLUSIONS: Frequency of SMS meals consumption is positively associated with improved nutrient intake among young Japanese women. However, given that the participants were dietetic students with relatively high nutrition literacy, caution is needed when generalising these findings to the wider population of young Japanese women. FAU - Yaegashi, Akinori AU - Yaegashi A AD - Department of Nutrition, Faculty of Health and Welfare, Takasaki University of Health and Welfare, Gunma, Japan. Email: yaegashi-a@takasaki-u.ac.jp. AD - Graduate School of Medicine, Hokkaido University, Hokkaido, Japan. FAU - Ota, Ai AU - Ota A AD - Freelance Researcher, Saitama, Japan. FAU - Shirahata, Aki AU - Shirahata A AD - Department of Health and Nutrition, Faculty of Human Science, Hokkaido Bunkyo University, Eniwa, Japan. FAU - Takada, Hiyori AU - Takada H AD - Department of Nutrition, School of Health Sciences, Sapporo University of Health Sciences, Hokkaido, Japan. FAU - Nakamura, Miki AU - Nakamura M AD - Department of Health and Nutrition, Faculty of Human Science, Hokkaido Bunkyo University, Eniwa, Japan. AD - Department of Nutrition, School of Health Sciences, Sapporo University of Health Sciences, Hokkaido, Japan. FAU - Katou, Hizuru AU - Katou H AD - Department of Health and Nutrition, Faculty of Human Science, Hokkaido Bunkyo University, Eniwa, Japan. FAU - Kozuka, Miyuki AU - Kozuka M AD - Department of Health and Nutrition, Faculty of Human Science, Hokkaido Bunkyo University, Eniwa, Japan. LA - eng PT - Journal Article PL - China TA - Asia Pac J Clin Nutr JT - Asia Pacific journal of clinical nutrition JID - 9440304 RN - Japanese people SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Japan MH - Young Adult MH - Adolescent MH - Adult MH - *Diet MH - *Nutritional Status MH - *Meals MH - *Feeding Behavior MH - Nutritional Requirements MH - Surveys and Questionnaires MH - East Asian People PMC - PMC13012828 OTO - NOTNLM OT - nutritional epidemiology OT - young woman OT - Japanese OT - nutritional adequacy OT - staple food COIS- No conflicts of interest are to be declared EDAT- 2026/03/28 00:42 MHDA- 2026/03/28 00:43 PMCR- 2026/03/17 CRDT- 2026/03/27 21:32 PHST- 2026/03/28 00:43 [medline] PHST- 2026/03/28 00:42 [pubmed] PHST- 2026/03/27 21:32 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - 10.6133/apjcn.202604_35(2).0003 [doi] PST - ppublish SO - Asia Pac J Clin Nutr. 2026 Apr;35(2):197-206. doi: 10.6133/apjcn.202604_35(2).0003. PMID- 41895696 OWN - NLM STAT- MEDLINE DCOM- 20260615 LR - 20260813 IS - 2156-5376 (Electronic) IS - 2161-8313 (Print) IS - 2161-8313 (Linking) VI - 17 IP - 6 DP - 2026 Jun TI - Healthy Diet Metrics for Children and Adolescents and Their Suitability for Global Monitoring: A Critical Review. PG - 100622 LID - S2161-8313(26)00036-0 [pii] LID - 10.1016/j.advnut.2026.100622 [doi] LID - 100622 AB - Healthy diets during childhood and adolescence are paramount for growth, development, and long-term health. However, there is a lack of low-burden standardized metrics to assess and monitor healthy diets among children and adolescents aged 2-19 y on a global scale. This critical review aimed to identify and evaluate existing metrics for assessing healthy diets in this age group and to determine their suitability for global monitoring based on feasibility and adaptability across different contexts. A systematic search was conducted across 3 global databases, encompassing both peer-reviewed and grey literature. A total of 127 distinct healthy diet metrics were identified, many of which were developed or adapted based on national dietary guidelines across various geographical contexts. Only 5 were deemed suitable for global monitoring due to their feasibility and adaptability: the Individual Dietary Diversity Score, 7 food group Minimum Dietary Diversity, 10 food group Minimum Dietary Diversity, Healthy Plate Variety Score, and Adapted ultraprocessed food Nova Score. Among these metrics, diversity was the most commonly measured subconstruct of a healthy diet, whereas only the Adapted Nova Score aimed to capture moderation. These 5 metrics were further evaluated for construct validity, reliability, and cross-context equivalence, which revealed large evidence gaps, particularly regarding sensitivity to change and test-retest reliability. These findings highlight the need for additional research to validate healthy diet metrics globally to ensure their accuracy, sensitivity, and reliability to differentiate populations and changes over time. Developing robust, low-burden metrics is essential for informing effective, timely nutrition policies and interventions aimed at improving the diets of children and adolescents worldwide. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Pries, Alissa M AU - Pries AM AD - Independent consultant, London, United Kingdom. Electronic address: hello@alissapries.com. FAU - Craig, Hope AU - Craig H AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States. FAU - Mehra, Vrinda AU - Mehra V AD - Data & Analytics Section, Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, United States. FAU - Frongillo, Edward A AU - Frongillo EA AD - Department of Health Promotion, Education, and Behavior, University of South Carolina, Columbia, SC, United States. FAU - Hanley-Cook, Giles T AU - Hanley-Cook GT AD - Food and Nutrition Division, Food and Agriculture Organization of the United Nations, Rome, Italy. FAU - Hayashi, Chika AU - Hayashi C AD - Data & Analytics Section, Division of Data, Analytics, Planning and Monitoring, United Nations Children's Fund, New York, NY, United States. FAU - Saha, Kuntal AU - Saha K AD - Department of Nutrition and Food Safety, World Health Organisation, Geneva, Switzerland. FAU - Sattamini, Isabela Fleury AU - Sattamini IF AD - Department of Nutrition and Food Safety, World Health Organisation, Geneva, Switzerland. FAU - Schwendler, Teresa R AU - Schwendler TR AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States. FAU - Coates, Jennifer C AU - Coates JC AD - Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, United States. CN - Healthy Diets Monitoring Initiative LA - eng PT - Journal Article PT - Review DEP - 20260325 PL - United States TA - Adv Nutr JT - Advances in nutrition (Bethesda, Md.) JID - 101540874 SB - IM MH - Humans MH - Child MH - Adolescent MH - *Diet, Healthy/standards MH - Child, Preschool MH - *Nutrition Policy MH - Reproducibility of Results MH - Evidence Gaps MH - Global Health PMC - PMC13223966 OTO - NOTNLM OT - adolescents OT - children OT - diets OT - global monitoring OT - metrics COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/03/28 00:42 MHDA- 2026/06/16 00:33 PMCR- 2026/03/25 CRDT- 2026/03/27 20:19 PHST- 2025/04/23 00:00 [received] PHST- 2026/02/02 00:00 [revised] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/06/16 00:33 [medline] PHST- 2026/03/28 00:42 [pubmed] PHST- 2026/03/27 20:19 [entrez] PHST- 2026/03/25 00:00 [pmc-release] AID - S2161-8313(26)00036-0 [pii] AID - 100622 [pii] AID - 10.1016/j.advnut.2026.100622 [doi] PST - ppublish SO - Adv Nutr. 2026 Jun;17(6):100622. doi: 10.1016/j.advnut.2026.100622. Epub 2026 Mar 25. PMID- 41895013 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260713 IS - 1872-8464 (Electronic) IS - 0165-5876 (Linking) VI - 204 DP - 2026 May TI - Preoperative immunonutritional and inflammatory indices as predictors of secondary post-tonsillectomy hemorrhage in children. PG - 112803 LID - S0165-5876(26)00098-4 [pii] LID - 10.1016/j.ijporl.2026.112803 [doi] AB - OBJECTIVE: Secondary post-tonsillectomy hemorrhage (PTH) remains a clinically significant complication in pediatric patients, and reliable preoperative predictors are limited. This study aimed to investigate the association between inflammatory and immunonutritional indices and secondary PTH, with particular emphasis on prognostic nutritional index (PNI) and hemoglobin-albumin-lymphocyte-platelet (HALP) score. METHODS: This retrospective cohort study included 2250 pediatric patients who underwent tonsillectomy or adenotonsillectomy. Ninety patients who developed secondary PTH were compared with 2160 patients without hemorrhage. Preoperative inflammatory and immunonutritional indices, including PNI, HALP, systemic immune-inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), were analyzed. In patients with secondary PTH, dynamic changes between the day of surgery (T0) and the day of bleeding (T1) were evaluated. Receiver operating characteristic (ROC) analyses were performed to assess predictive performance. RESULTS: Patients with secondary PTH demonstrated significantly lower preoperative PNI and HALP values, along with higher SII, NLR, and PLR levels compared with patients without hemorrhage (all p < 0.001). In the PTH group, PNI and HALP declined significantly on the bleeding day, whereas inflammatory indices increased (p < 0.001). ROC analysis showed that PNI (AUC = 0.704) and HALP (AUC = 0.666) provided meaningful discrimination for secondary PTH, comparable to traditional inflammatory markers. CONCLUSION: Both preoperative and dynamic peri-hemorrhagic changes in immunonutritional indices are closely associated with secondary post-tonsillectomy hemorrhage. PNI and HALP may serve as practical adjunctive tools for risk stratification, supporting a multidimensional inflammatory-nutritional assessment in pediatric tonsillectomy patients. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Egilmez, Oguz Kadir AU - Egilmez OK AD - Sakarya University Training and Research Hospital, Department of Otorhinolaryngology, Sakarya, Turkey. Electronic address: oguzegilmez@gmail.com. FAU - Elden, Halil AU - Elden H AD - Sakarya University Training and Research Hospital, Department of Otorhinolaryngology, Sakarya, Turkey. FAU - Kandemir, Aykan AU - Kandemir A AD - Sakarya University Training and Research Hospital, Department of Otorhinolaryngology, Sakarya, Turkey. LA - eng PT - Journal Article DEP - 20260324 PL - Ireland TA - Int J Pediatr Otorhinolaryngol JT - International journal of pediatric otorhinolaryngology JID - 8003603 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Tonsillectomy/adverse effects MH - Female MH - Male MH - Retrospective Studies MH - *Postoperative Hemorrhage/etiology/epidemiology MH - Child MH - Child, Preschool MH - Inflammation MH - Predictive Value of Tests MH - Prognosis MH - ROC Curve MH - Preoperative Care/methods MH - Nutrition Assessment MH - Cohort Studies MH - Nutritional Status MH - Biomarkers/blood OTO - NOTNLM OT - HALP score OT - Pediatric tonsillectomy OT - Post-tonsillectomy hemorrhage OT - Prognostic nutritional index OT - Systemic immune-inflammation index COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/28 00:42 MHDA- 2026/04/24 00:32 CRDT- 2026/03/27 19:07 PHST- 2026/01/03 00:00 [received] PHST- 2026/03/01 00:00 [revised] PHST- 2026/03/22 00:00 [accepted] PHST- 2026/04/24 00:32 [medline] PHST- 2026/03/28 00:42 [pubmed] PHST- 2026/03/27 19:07 [entrez] AID - S0165-5876(26)00098-4 [pii] AID - 10.1016/j.ijporl.2026.112803 [doi] PST - ppublish SO - Int J Pediatr Otorhinolaryngol. 2026 May;204:112803. doi: 10.1016/j.ijporl.2026.112803. Epub 2026 Mar 24. PMID- 41894591 OWN - NLM STAT- MEDLINE DCOM- 20260610 LR - 20260909 IS - 1097-4679 (Electronic) IS - 0021-9762 (Print) IS - 0021-9762 (Linking) VI - 82 IP - 7 DP - 2026 Jul TI - Relative Contributions of Gastrointestinal-Specific Hypervigilance and Anxiety in Explaining Eating Disorder Symptoms. PG - 1078-1085 LID - 10.1002/jclp.70134 [doi] AB - OBJECTIVE: Gastrointestinal (GI) disturbances and eating disorder symptoms commonly co-occur. Hypervigilance and anxiety about GI symptoms may motivate eating disorder behaviors to manage and/or avoid GI symptoms. We hypothesized that GI-specific anxiety would be more strongly associated with dietary restriction and purging than GI-specific hypervigilance. Further, we hypothesized that distinguishing between GI-specific anxiety and hypervigilance would have incremental validity over using an existing measure of GI-anxiety and related constructs initially developed for patients with irritable bowel syndrome, the Visceral Sensitivity Index. METHODS: Three hundred and eighty-two undergraduate students with elevated eating pathology (83.5% female, 87.4% White) completed questionnaires assessing GI-specific hypervigilance and anxiety, the Visceral Sensitivity Index, and eating disorder symptoms. Participants were recruited with elevated shape/weight-oriented eating pathology (N = 309) and elevated avoidant/restrictive food intake disorder-related eating pathology (N = 73). Analyses were pre-registered. RESULTS: Regarding dietary restriction, the relative weight of GI-specific anxiety did not differ from that of GI-specific hypervigilance. Further, neither variable provided incremental validity over the Visceral Sensitivity Index in understanding restriction. Regarding purging, GI-specific anxiety was not more strongly associated with purging than GI-specific hypervigilance. However, GI-specific anxiety, but not GI-specific hypervigilance, demonstrated incremental validity over the Visceral Sensitivity Index in explaining purging. CONCLUSION: Distinguishing between GI-specific hypervigilance and anxiety adds incremental validity in understanding purging but not restriction. Future research should examine whether addressing anxious cognitions about GI symptoms improves purging outcomes. CI - (c) 2026 The Author(s). Journal of Clinical Psychology published by Wiley Periodicals LLC. FAU - Pucci, Gabriella AU - Pucci G AD - Department of Psychology, Ohio University, Athens, Ohio, USA. FAU - Hill, Naomi G AU - Hill NG AUID- ORCID: 0000-0002-6955-1746 AD - Department of Psychology, Ohio University, Athens, Ohio, USA. FAU - Schneider, Zoe AU - Schneider Z AD - Department of Psychology, Ohio University, Athens, Ohio, USA. AD - Carnegie Mellon University, Pittsburgh, Pennsylvania, USA. FAU - Brown, Tiffany A AU - Brown TA AUID- ORCID: 0000-0002-7349-7228 AD - Department of Psychological Sciences, Auburn University, Auburn, Alabama, USA. FAU - Burton-Murray, Helen AU - Burton-Murray H AUID- ORCID: 0000-0003-2059-3256 AD - Division of Gastroenterology, Center for Neurointestinal Health, Massachusetts General Hospital, Boston, Massachusetts, USA. AD - Harvard Medical School, Boston, Massachusetts, USA. FAU - Guadagnoli, Livia AU - Guadagnoli L AUID- ORCID: 0000-0002-2925-3955 AD - Department of Gastroenterology and Hepatology, Northwestern Feinberg School of Medicine, Chicago, Illinois, USA. FAU - Forney, K Jean AU - Forney KJ AD - Department of Psychology, Ohio University, Athens, Ohio, USA. LA - eng GR - K23 DK131334/DK/NIDDK NIH HHS/United States GR - K23 DK131334/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, P.H.S. DEP - 20260327 PL - United States TA - J Clin Psychol JT - Journal of clinical psychology JID - 0217132 SB - IM MH - Humans MH - Female MH - *Anxiety/physiopathology MH - *Feeding and Eating Disorders/physiopathology/psychology MH - Male MH - *Gastrointestinal Diseases/physiopathology/psychology MH - Young Adult MH - Adult MH - Adolescent PMC - PMC13104586 MID - NIHMS2165072 OTO - NOTNLM OT - anxiety OT - feeding and eating disorders OT - gastrointestinal symptoms OT - hypervigilance OT - purging OT - restriction COIS- H.B.-M. receives royalties from Oxford University Press for her book Cognitive Behavioral Therapy for Rumination Syndrome and from Cambridge University Press for her forthcoming book on functional bowel disorders. The other authors declare no conflicts of interest. EDAT- 2026/03/27 18:52 MHDA- 2026/06/10 06:52 PMCR- 2026/06/06 CRDT- 2026/03/27 14:53 PHST- 2026/02/19 00:00 [revised] PHST- 2025/08/29 00:00 [received] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/06/10 06:52 [medline] PHST- 2026/03/27 18:52 [pubmed] PHST- 2026/03/27 14:53 [entrez] PHST- 2026/06/06 00:00 [pmc-release] AID - JCLP70134 [pii] AID - 10.1002/jclp.70134 [doi] PST - ppublish SO - J Clin Psychol. 2026 Jul;82(7):1078-1085. doi: 10.1002/jclp.70134. Epub 2026 Mar 27. PMID- 41894565 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260327 LR - 20260925 IS - 1929-073X (Print) IS - 1929-073X (Electronic) IS - 1929-073X (Linking) VI - 15 DP - 2026 Mar 27 TI - The Lifetime Dance Exposure Questionnaire for Professional Training: Survey Development and Reliability Study. PG - e75632 LID - 10.2196/75632 [doi] LID - e75632 AB - BACKGROUND: Dance is a complex mode of physical activity (PA) behavior and an art form, and one's participation in dance may occur across discrete contexts throughout the lifespan. To further advance the study of lifetime participation in dance behavior, reliable questionnaires are needed. OBJECTIVE: This study aimed to develop and test the reliability of a self-report, online questionnaire for surveilling lifetime participation in professionally led dance classes among adults. METHODS: Community-dwelling adults (N=373) completed the Lifetime Dance Exposure Questionnaire for Professional Training (LDEQ-T) at baseline (T1), and 150 adults repeated the LDEQ-T after an 8-week delay (T2). Test-retest reliability for self-reported dance training frequency, duration, and PA intensity was analyzed for the LDEQ-T between T1 and T2. Reliability for the LDEQ-T item on total years of professional dance training was assessed using intraclass correlation coefficients (ICCs; 2-way, random effects); linearly weighted kappa (𝜿w) was used for ordinal variables on dance class duration, intensity, and frequency; an unweighted kappa (𝜿) statistic was used to test the reliability of 3 dance training exposure groups (no or low, homogenous, or variable lifetime exposure to professional dance training). The significance level was set a priori with alpha=.05. RESULTS: Adults reported having no or low (n=92), homogenous (n=196), or variable (n=85) lifetime exposures to professional dance classes at T1. Among adults who self-reported homogenous exposures to dance training throughout the lifespan, years of dance training were found to be reliable across all age periods (ICC range 0.83-0.94); as were weeks/month, months/year, and hours/week of dance training (𝜿w range 0.35-0.61); but not any measure of PA intensity. Among adults who self-reported variable exposures to dance training, years of dance training across all age periods (ICC=0.70-0.96); classes/week, weeks/month, months/year, and hours/week (𝜿w range 0.32-0.56); and some estimates of PA intensity (𝜿w range 0.30-0.41) were found to be sufficiently reliable. CONCLUSIONS: The LDEQ-T appears to be a reliable instrument for quantifying lifetime participation in professional dance training among adults with self-reported low, homogenous, or variable exposures to professional dance classes throughout the lifespan. Among adults, researchers may surveil lifetime exposure to dance training in early childhood, childhood, adolescence, young adulthood, and middle or older adulthood using the LDEQ-T. CI - (c) Aston K McCullough, Kai Yi (Kaye) Han. Originally published in the Interactive Journal of Medical Research (https://www.i-jmr.org/). FAU - McCullough, Aston K AU - McCullough AK AUID- ORCID: 0000-0003-2021-5554 AD - Laboratory for the Scientific Study of Dance, Institute for Cognitive and Brain Health, Northeastern University, 360 Huntington Ave, 129 ISEC, Boston, MA, 02115, United States, 1 6173738893. AD - Department of Physical Therapy, Movement and Rehabilitation Sciences, Northeastern University, Boston, MA, United States. AD - Department of Music, Northeastern University, Boston, MA, United States. FAU - Han, Kai Yi Kaye AU - Han KYK AUID- ORCID: 0009-0004-9277-5811 AD - Laboratory for the Scientific Study of Dance, Institute for Cognitive and Brain Health, Northeastern University, 360 Huntington Ave, 129 ISEC, Boston, MA, 02115, United States, 1 6173738893. LA - eng PT - Journal Article DEP - 20260327 PL - Canada TA - Interact J Med Res JT - Interactive journal of medical research JID - 101598421 PMC - PMC13026436 OTO - NOTNLM OT - adult OT - physical activity OT - self-report OT - survey OT - test-retest reliability COIS- Conflicts of Interest: None declared. EDAT- 2026/03/27 18:51 MHDA- 2026/03/27 18:52 PMCR- 2026/03/27 CRDT- 2026/03/27 14:22 PHST- 2025/04/07 00:00 [received] PHST- 2025/12/11 00:00 [revised] PHST- 2025/12/17 00:00 [accepted] PHST- 2026/03/27 18:52 [medline] PHST- 2026/03/27 18:51 [pubmed] PHST- 2026/03/27 14:22 [entrez] PHST- 2026/03/27 00:00 [pmc-release] AID - v15i1e75632 [pii] AID - 75632 [pii] AID - 10.2196/75632 [doi] PST - epublish SO - Interact J Med Res. 2026 Mar 27;15:e75632. doi: 10.2196/75632. PMID- 41894120 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Mar 27 TI - Cognitive remediation therapy (CRT-O) for young Indian adults living with overweight or obesity: a qualitative study of participant experience. LID - 10.1007/s40519-026-01845-5 [doi] LID - 43 AB - BACKGROUND: The prevalence of obesity in India has reached epidemic levels with 40.3% living with overweight or obesity. Problematic eating behaviours have been implicated in the development and maintenance of overweight and obesity. Conventional cognitive-behavioural intervention for eating disorders has not shown favourable long-term outcomes in weight management. Recent research has indicated early evidence for using cognitive remediation therapy (CRT-O) for eating disorders including disordered eating behaviours in those living with overweight and obesity. We conducted a feasibility study through a randomized controlled trial (RCT) with 70 young Indian adults with obesity or overweight. We also obtained participant feedback post-intervention, to identify putative contributing factors to the study outcomes. METHODOLOGY: Fifteen young adult participants completed 28 sessions of CRT-O intervention program for their weight management. On trial completion, participants were randomly selected to provide their feedback and experience of their participation. A semi-structured qualitative interview was conducted. Transcripts were semantically coded and thematic analysis was done. RESULTS: Thematic analysis yielded six themes: 1. gaining new insights into their eating habits; 2. self-reported changes in eating behaviours; 3. self-reported behavioural changes; 4. perceived physical benefits; 5. perceived psychological benefits; 6. perceptions about the CRT-program. The sub-themes that emerged indicated general acceptance of the CRT-O intervention and its potential translation in real life. CONCLUSIONS: This study showed improved metacognitive awareness on participants' eating behaviours. Additionally, the findings indicated that participants developed an improved ability to resist several highly palatable but unhealthy foods. Participants also reported experiencing more self-control in their food grazing habits and reported that this led to a better ability to manage their weight. CI - (c) 2026. The Author(s). FAU - Susilkumar, Vandhana AU - Susilkumar V AD - Saveetha Institute of Medical & Technical Sciences (SIMATS), Chennai, Tamil Nadu, India. FAU - Sukumaran, Bhasi AU - Sukumaran B AD - SRM Medical College Hospital and Research Centre, SRM Institute of Science and Technology, Chengalpattu Dt., Kattankulathur, Tamil Nadu, India. FAU - Kumar, Radha AU - Kumar R AD - Saveetha Institute of Medical & Technical Sciences (SIMATS), Chennai, Tamil Nadu, India. FAU - Raman, Jayanthi AU - Raman J AD - School of Psychological Sciences, University of Newcastle, University Drive Callaghan, Newcastle, NSW, 2308, Australia. Jay.Raman@newcastle.edu.au. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260327 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - Female MH - *Overweight/therapy/psychology MH - *Obesity/therapy/psychology MH - *Cognitive Remediation/methods MH - Young Adult MH - Male MH - Adult MH - India MH - *Feeding Behavior/psychology MH - Qualitative Research MH - Treatment Outcome MH - Feasibility Studies MH - Adolescent MH - Cognitive Behavioral Therapy PMC - PMC13149649 OTO - NOTNLM OT - Cognitive remediation therapy (CRT-O) OT - Disordered eating OT - Obesity OT - Qualitative analysis COIS- Declarations: The authors received no financial support for this study and declare no conflicts of interest. All authors contributed to the study's conception and design. The material preparation, data collection, and analysis were done by Vandhana Susilkumar who also drafted the manuscript. All authors reviewed and approved the final version. The study adheres to the Declaration of Helsinki, with ethical approval from the Saveetha Medical College & Hospital Institutional Ethics Committee (Ref No: 010/06/2021/IEC/SMCH). Data from the study are available upon request, and informed consent was obtained from all participants. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Saveetha Medical College & Hospital Institutional Ethics Committee (SMCH-IEC) Ref No: 010/06/2021/IEC/SMCH. Consent to participate: Informed consent was obtained from all individual participants included in the study. Competing interests: The authors have no conflicts of interest to declare EDAT- 2026/03/27 18:52 MHDA- 2026/05/07 00:33 PMCR- 2026/03/27 CRDT- 2026/03/27 12:17 PHST- 2025/03/18 00:00 [received] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/05/07 00:33 [medline] PHST- 2026/03/27 18:52 [pubmed] PHST- 2026/03/27 12:17 [entrez] PHST- 2026/03/27 00:00 [pmc-release] AID - 10.1007/s40519-026-01845-5 [pii] AID - 1845 [pii] AID - 10.1007/s40519-026-01845-5 [doi] PST - epublish SO - Eat Weight Disord. 2026 Mar 27;31(1):43. doi: 10.1007/s40519-026-01845-5. PMID- 41894105 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Mar 27 TI - Dietary intake of women with and without eating disorder history from pregnancy to 3 years postpartum: a longitudinal analysis. LID - 10.1007/s40519-026-01841-9 [doi] LID - 26 AB - BACKGROUND: Pregnancy and the postpartum period are vulnerable phases, particularly for women with eating disorder (ED) history. While prior nutritional research has mainly focused on pregnancy, little is known about long-term dietary patterns in this population. This study examined dietary intake in women with and without ED history from pregnancy to 3 years postpartum. METHODS: A validated food frequency questionnaire (FFQ) assessed dietary intake in women with ED history (ED group, T1: active ED: n = 12, past ED: n = 12) and healthy controls (HC group, T1: n = 33). Dietary patterns, food groups, as well as macro- und micronutrient intakes were analysed during pregnancy (T1), 1 year postpartum (T2), and 3 years postpartum (T3). RESULTS: Omnivorous diets predominated (T1: 75.4%, T2: 73.2% T3: 74.4%), with no significant differences between groups or over time. However, women with ED history consumed fewer animal-based, energy-dense, sugar- and fat-rich foods. Nutrient intake during pregnancy was comparable between groups. Postpartum, the ED group showed lower fat intake (p = 0.027, T2) higher fiber intake (p = 0.037, T3) and lower vitamin B12 intake (p = 0.031, T3). CONCLUSION: Nutrient supply during pregnancy was comparable between groups, which is encouraging. Differences in food group consumption may reflect a greater health consciousness or residual restrictive behaviors in women with ED history. Given the known increase in ED symptoms after childbirth, these findings emphasize the need to further examine this nutritionally and psychosocially vulnerable period. LEVEL OF EVIDENCE: Level 3. CI - (c) 2026. The Author(s). FAU - Schmidt, Louise Auguste AU - Schmidt LA AD - Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tuebingen, Osianderstrasse 5, 72076, Tuebingen, Germany. Louise.schmidt@med.uni-tuebingen.de. AD - Center of Excellence for Eating Disorders (KOMET), University Hospital Tuebingen, Tuebingen, Germany. Louise.schmidt@med.uni-tuebingen.de. FAU - Throm, Jana Katharina AU - Throm JK AD - Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tuebingen, Osianderstrasse 5, 72076, Tuebingen, Germany. AD - Center of Excellence for Eating Disorders (KOMET), University Hospital Tuebingen, Tuebingen, Germany. FAU - Dorsam, Annica Franziska AU - Dorsam AF AD - Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tuebingen, Osianderstrasse 5, 72076, Tuebingen, Germany. AD - Center of Excellence for Eating Disorders (KOMET), University Hospital Tuebingen, Tuebingen, Germany. FAU - Giel, Katrin Elisabeth AU - Giel KE AD - Department of Psychosomatic Medicine and Psychotherapy, University Hospital Tuebingen, Osianderstrasse 5, 72076, Tuebingen, Germany. AD - Center of Excellence for Eating Disorders (KOMET), University Hospital Tuebingen, Tuebingen, Germany. LA - eng GR - Project No. F1292064/Medical Faculty of the University of Tuebingen, within the framework of the fortune programme/ PT - Journal Article DEP - 20260327 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Postpartum Period MH - Adult MH - *Feeding and Eating Disorders/psychology MH - Longitudinal Studies MH - *Diet MH - *Feeding Behavior/psychology MH - Energy Intake/physiology MH - *Eating/psychology/physiology MH - Young Adult PMC - PMC13065583 OTO - NOTNLM OT - Eating behaviour OT - Eating disorders OT - Nutrition OT - Postpartum OT - Pregnancy COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/03/27 18:52 MHDA- 2026/04/09 12:46 PMCR- 2026/03/27 CRDT- 2026/03/27 12:17 PHST- 2025/12/23 00:00 [received] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/04/09 12:46 [medline] PHST- 2026/03/27 18:52 [pubmed] PHST- 2026/03/27 12:17 [entrez] PHST- 2026/03/27 00:00 [pmc-release] AID - 10.1007/s40519-026-01841-9 [pii] AID - 1841 [pii] AID - 10.1007/s40519-026-01841-9 [doi] PST - epublish SO - Eat Weight Disord. 2026 Mar 27;31(1):26. doi: 10.1007/s40519-026-01841-9. PMID- 41892828 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 2076-3271 (Electronic) IS - 2076-3271 (Linking) VI - 14 IP - 1 DP - 2026 Feb 26 TI - Purpose in Life and Estimated Type 2 Diabetes Risk: Cross-Sectional Associations Across Three Validated Risk Scores in 93,077 Spanish Working Adults. LID - 10.3390/medsci14010113 [doi] LID - 113 AB - Background: Psychosocial well-being has been increasingly recognized as a relevant factor in cardiometabolic health; however, evidence linking Purpose in Life with type 2 diabetes risk across validated prediction tools remains limited. This study examined the association between Purpose in Life and estimated diabetes risk using three established risk scores. Methods: A cross-sectional analysis was performed in 93,077 Spanish working adults aged 18-69 years participating in routine occupational health assessments. Purpose in Life was measured with the 10-item Purpose in Life scale and categorized into high, moderate, and low levels. Estimated type 2 diabetes risk was evaluated using QDScore, FINDRISC, and CANRISK. Multivariable logistic regression models were applied to calculate odds ratios (ORs) and 95% confidence intervals (CIs), adjusting for age, sex, occupational social class, smoking status, dietary pattern, physical activity, and body mass index. Results: Lower levels of Purpose in Life were consistently associated with greater likelihood of high estimated diabetes risk across all three instruments. Compared with participants reporting high Purpose in Life, those with low Purpose in Life showed increased odds of high-risk classification for QDScore (OR 2.38; 95% CI 2.19-2.57), FINDRISC (OR 2.49; 95% CI 2.08-2.89), and CANRISK (OR 2.79; 95% CI 2.50-3.09). Clear dose-response patterns were observed across Purpose in Life categories, and associations were similar in men and women as well as across lifestyle strata. Conclusions: Reduced Purpose in Life is strongly associated with higher estimated type 2 diabetes risk across multiple validated screening tools. Although causal direction cannot be inferred from this cross-sectional design, these findings suggest that psychosocial dimensions may provide complementary information for cardiometabolic risk assessment and prevention strategies. FAU - Garcia Pertegaz, Pilar AU - Garcia Pertegaz P AUID- ORCID: 0009-0006-9309-0480 AD - Quiron Salud Palma Planas Hospital, 07014 Palma, Spain. FAU - Tarraga Lopez, Pedro Juan AU - Tarraga Lopez PJ AUID- ORCID: 0000-0002-5222-5784 AD - Faculty of Medicine, University of Castilla La Mancha (UCLM), 02008 Albacete, Spain. FAU - Coll Campayo, Irene AU - Coll Campayo I AUID- ORCID: 0000-0002-5423-9290 AD - ADEMA-University School, University of the Balearic Islands,07009 Palma, Spain. FAU - Busquets-Cortes, Carla AU - Busquets-Cortes C AUID- ORCID: 0000-0001-9367-2137 AD - ADEMA-University School, University of the Balearic Islands,07009 Palma, Spain. FAU - Lopez-Gonzalez, Angel Arturo AU - Lopez-Gonzalez AA AUID- ORCID: 0000-0002-7439-8117 AD - ADEMA-University School, University of the Balearic Islands,07009 Palma, Spain. FAU - Ramirez-Manent, Jose Ignacio AU - Ramirez-Manent JI AUID- ORCID: 0000-0001-6887-4562 AD - ADEMA-University School, University of the Balearic Islands,07009 Palma, Spain. AD - Faculty of Medicine, University of the Balearic Islands, 07120 Palma, Spain. LA - eng PT - Journal Article DEP - 20260226 PL - Switzerland TA - Med Sci (Basel) JT - Medical sciences (Basel, Switzerland) JID - 101629322 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/epidemiology/psychology MH - Female MH - Middle Aged MH - Male MH - Adult MH - Cross-Sectional Studies MH - Spain/epidemiology MH - Aged MH - Risk Factors MH - Adolescent MH - Young Adult MH - Risk Assessment PMC - PMC13028122 OTO - NOTNLM OT - cardiometabolic health OT - diabetes risk scores OT - occupational population OT - psychosocial factors OT - purpose in life OT - type 2 diabetes risk COIS- The authors declare no conflicts of interest. EDAT- 2026/03/27 17:37 MHDA- 2026/03/27 17:38 PMCR- 2026/02/26 CRDT- 2026/03/27 11:22 PHST- 2026/01/30 00:00 [received] PHST- 2026/02/16 00:00 [revised] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/03/27 17:38 [medline] PHST- 2026/03/27 17:37 [pubmed] PHST- 2026/03/27 11:22 [entrez] PHST- 2026/02/26 00:00 [pmc-release] AID - medsci14010113 [pii] AID - medsci-14-00113 [pii] AID - 10.3390/medsci14010113 [doi] PST - epublish SO - Med Sci (Basel). 2026 Feb 26;14(1):113. doi: 10.3390/medsci14010113. PMID- 41892778 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260327 LR - 20260813 IS - 2304-6767 (Electronic) IS - 2304-6767 (Linking) VI - 14 IP - 3 DP - 2026 Mar 16 TI - Predicting Dental Anxiety and Cooperative Behavior in Children Using Machine Learning: A Cross-Sectional Predictive Modeling Study. LID - 10.3390/dj14030170 [doi] LID - 170 AB - Background/Objectives: Dental anxiety and uncooperative behavior present significant challenges in pediatric dentistry and may adversely affect treatment outcomes and oral health. The main goal of this study was to evaluate the predictive performance of machine learning models in classifying dental anxiety measured using the Abeer Children Dental Anxiety Scale (ACDAS), predicting uncooperative behavior, estimating continuous dental anxiety scores, and identifying key predictors among children aged 6-11 years attending pediatric dental clinics in Jeddah, Saudi Arabia. Methods: This is an analytical cross-sectional study conducted among 952 children to evaluate whether machine learning models could predict dental anxiety and cooperative behavior based on demographic, clinical, and behavioral variables. Twenty variables captured demographic, medical, and dental history, BMI, and anxiety/behavioral measures. Data preprocessing included removing sparse variables, imputing missing values, and encoding categorical and ordinal variables appropriately. Logistic Regression models were trained to classify dental anxiety and cooperative behavior. A Random Forest Regressor was used to predict continuous anxiety scores, and a Random Forest Classifier was used for feature importance analysis. Principal Component Analysis (PCA) and K-Means clustering were applied to explore behavioral subgroups. Results: This dataset shows the Logistic Regression model with 0.92 accuracy (ROC AUC 0.98) for predicting dental anxiety and 0.91 accuracy (ROC AUC 0.95) for cooperative behavior. The Random Forest Regressor predicted anxiety scores with R(2) = 0.97. Feature importance revealed that sensory and cognitive responses were key predictors of anxiety and cooperation. Unsupervised clustering identified two behavioral profiles: one with lower and another with higher anxiety and cooperation. Conclusions: ML models demonstrated strong prediction of dental anxiety and cooperation in this pediatric sample. While promising for early detection and personalized management of anxious or uncooperative children, further validation is essential before clinical use. FAU - Helal, Narmin M AU - Helal NM AUID- ORCID: 0000-0002-3194-7358 AD - Pediatric Dentistry Department, King Abdulaziz University, Jeddah 21589, Saudi Arabia. FAU - Sabbagh, Heba AU - Sabbagh H AUID- ORCID: 0000-0002-9788-0379 AD - Pediatric Dentistry Department, King Abdulaziz University, Jeddah 21589, Saudi Arabia. LA - eng GR - IPP; 237-165-2025/This project was funded by the Deanship of Scientific Research (DSR) at King Abdulaziz University/ PT - Journal Article DEP - 20260316 PL - Switzerland TA - Dent J (Basel) JT - Dentistry journal JID - 101716125 PMC - PMC13025896 OTO - NOTNLM OT - cooperative behavior OT - dental anxiety OT - machine learning OT - pediatric dentistry OT - predictive modeling COIS- The authors declare no conflict of interest. EDAT- 2026/03/27 17:38 MHDA- 2026/03/27 17:39 PMCR- 2026/03/16 CRDT- 2026/03/27 11:17 PHST- 2026/01/29 00:00 [received] PHST- 2026/02/23 00:00 [revised] PHST- 2026/03/10 00:00 [accepted] PHST- 2026/03/27 17:39 [medline] PHST- 2026/03/27 17:38 [pubmed] PHST- 2026/03/27 11:17 [entrez] PHST- 2026/03/16 00:00 [pmc-release] AID - dj14030170 [pii] AID - dentistry-14-00170 [pii] AID - 10.3390/dj14030170 [doi] PST - epublish SO - Dent J (Basel). 2026 Mar 16;14(3):170. doi: 10.3390/dj14030170. PMID- 41892647 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260327 LR - 20260813 IS - 2076-3425 (Print) IS - 2076-3425 (Electronic) IS - 2076-3425 (Linking) VI - 16 IP - 3 DP - 2026 Mar 12 TI - Sleep Disturbances and Non-REM Phase Alterations in Children with Celiac Disease: A Combined Questionnaire and EEG Study. LID - 10.3390/brainsci16030304 [doi] LID - 304 AB - Background: Celiac disease (CD) is a multisystem immune-mediated disorder increasingly recognized to affect sleep and neurobehavioral functioning. Pediatric data remain limited, and no prior study has examined especially for sleep microstructure in this population. This study evaluates the prevalence and patterns of sleep disturbances in children with CD using the Sleep Disturbance Scale for Children (SDSC) and explores potential electrophysiological correlates through N2 sleep spindle analysis. Methods: Children with biopsy-confirmed CD (n = 31) and age-matched controls (n = 25) completed the SDSC. A subgroup of CD patients with SDSC >/= 35 and healthy controls underwent quantitative sleep spindle analysis (C3, C4, O1, O2) using automated and visual verification methods combined. Results: Clinically significant sleep disturbances were substantially more prevalent in CD than in controls (77.4% vs. 12%). Excessive somnolence, sleep-wake transition disorders, and sleep hyperhidrosis were the most affected domains. Moreover, among children with CD, those noncompliant with a gluten-free diet exhibited higher rates of excessive somnolence and sleep-wake transition disorders. While spindle parameters did not differ between groups, higher SDSC scores (>/=35)-particularly in the somnolence and sleep-wake transition disorder domains-are associated with reduced spindle amplitude and density, suggesting that spindle alterations are linked to sleep disturbance severity rather than disease status per se. Conclusions: Sleep disturbances are common in pediatric CD and worsen with poor dietary adherence. Although sleep microarchitecture is largely preserved, reduced spindle activity is evident in children with higher subjective sleep burden, suggesting that spindle metrics may serve as potential objective markers for sleep disturbance. Longitudinal studies are required for validation. FAU - Sari Yanartas, Mehpare AU - Sari Yanartas M AD - Department of Pediatric Neurology, Faculty of Medicine, Akdeniz University, 07100 Antalya, Turkiye. FAU - Inan Aydemir, Nurel AU - Inan Aydemir N AUID- ORCID: 0000-0002-8614-4392 AD - Antalya City Hospital, 07070 Antalya, Turkiye. FAU - Donbaloglu, Furkan AU - Donbaloglu F AD - Department of Pediatric Neurology, Faculty of Medicine, Akdeniz University, 07100 Antalya, Turkiye. FAU - Tsakir, Chakan AU - Tsakir C AUID- ORCID: 0000-0003-1434-5192 AD - Department of Pediatric Neurology, Faculty of Medicine, Akdeniz University, 07100 Antalya, Turkiye. FAU - Yayici Koken, Ozlem AU - Yayici Koken O AUID- ORCID: 0000-0003-2112-8284 AD - Department of Pediatric Neurology, Faculty of Medicine, Akdeniz University, 07100 Antalya, Turkiye. FAU - Sanlidag, Burcin AU - Sanlidag B AUID- ORCID: 0000-0003-1011-475X AD - Department of Pediatric Neurology, Faculty of Medicine, Near East University, 99138 Nicosia, Cyprus. FAU - Ture, Senay AU - Ture S AUID- ORCID: 0000-0001-6123-1943 AD - Division of Social Pediatrics, Department of Pediatrics, Faculty of Medicine, Akdeniz University, 07100 Antalya, Turkiye. FAU - Sekeroglu, Boran AU - Sekeroglu B AUID- ORCID: 0000-0001-7284-1173 AD - Department of Computer Engineering, Faculty of AI and Informatics, Near East University, 99138 Nicosia, Cyprus. FAU - Yilmaz, Aygen AU - Yilmaz A AD - Department of Pediatric Gastroenterology, Faculty of Medicine, Akdeniz University, 07100 Antalya, Turkiye. FAU - Haspolat, Senay AU - Haspolat S AD - Department of Pediatric Neurology, Faculty of Medicine, Akdeniz University, 07100 Antalya, Turkiye. LA - eng GR - TSA-2024-6515./Akdeniz University Scientific Research Projects Coordination Unit/ PT - Journal Article DEP - 20260312 PL - Switzerland TA - Brain Sci JT - Brain sciences JID - 101598646 PMC - PMC13024523 OTO - NOTNLM OT - celiac disease OT - electroencephalography OT - pediatrics OT - sleep disturbances OT - sleep spindles COIS- The authors declare no conflict of interest. EDAT- 2026/03/27 17:37 MHDA- 2026/03/27 17:38 PMCR- 2026/03/12 CRDT- 2026/03/27 11:16 PHST- 2026/01/25 00:00 [received] PHST- 2026/02/26 00:00 [revised] PHST- 2026/03/10 00:00 [accepted] PHST- 2026/03/27 17:38 [medline] PHST- 2026/03/27 17:37 [pubmed] PHST- 2026/03/27 11:16 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - brainsci16030304 [pii] AID - brainsci-16-00304 [pii] AID - 10.3390/brainsci16030304 [doi] PST - epublish SO - Brain Sci. 2026 Mar 12;16(3):304. doi: 10.3390/brainsci16030304. PMID- 41892645 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260327 LR - 20260813 IS - 2076-3425 (Print) IS - 2076-3425 (Electronic) IS - 2076-3425 (Linking) VI - 16 IP - 3 DP - 2026 Mar 10 TI - Sleep Duration and Physical Activity as Predictors of Executive Function in Adolescents: A Longitudinal Study. LID - 10.3390/brainsci16030302 [doi] LID - 302 AB - Background/Objectives: Adolescence is a critical period for executive function (EF) maturation. While sleep and physical activity (PA) are key lifestyle factors, their longitudinal impact on EF in ecologically valid settings is insufficiently characterised. This study examined the associations between objectively measured sleep duration, daily steps, and EF performance across one academic year (~9 months). Methods: A longitudinal study was conducted with 168 Spanish adolescents (13-16 years). Sleep duration and daily steps were monitored using Fitbit Charge 6 wearables for 7-day periods at baseline (M1; September 2024) and follow-up (M2; June 2025). EFs were assessed using three validated tasks: Stroop (inhibitory control), Psychomotor Vigilance Task-Brief (PVT-B; sustained attention), and Paced Auditory Serial Addition Test (PASAT; working memory). Linear Mixed Models (LMM) were employed to analyse the effects of the fixed factors (i.e., Group and Time), and their interactions. Results: PA, but not sleep duration, significantly predicted executive performance. The High_PA group demonstrated faster reaction times in inhibitory control (p = 0.007) and significantly fewer attentional lapses in sustained attention (p = 0.014). In contrast, sleep duration showed no significant main effects on EF domains (p > 0.05). Regression analyses confirmed that higher daily steps predicted faster reaction times in inhibitory control in the total sample (r = -0.173, p = 0.002), although an unexpected positive association was observed in the Low_PA group for inhibitory control, warranting cautious interpretation. Conclusions: These findings suggest that habitual PA is associated with better EF performance in adolescents, whereas sleep duration alone (without considering timing or variability) showed no significant associations with cognitive outcomes. Sensitivity analyses using clinically informed thresholds and continuous standardised predictors confirmed the robustness of these findings. FAU - Ayuso-Moreno, Rosa AU - Ayuso-Moreno R AUID- ORCID: 0000-0003-2761-7249 AD - Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. FAU - Rubio-Morales, Ana AU - Rubio-Morales A AUID- ORCID: 0000-0003-1062-1989 AD - Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. FAU - Llanos-Munoz, Ruben AU - Llanos-Munoz R AUID- ORCID: 0000-0003-4961-9376 AD - Faculty of Teacher Training, University of Extremadura, 10003 Caceres, Spain. FAU - Garcia-Calvo, Tomas AU - Garcia-Calvo T AUID- ORCID: 0000-0002-2550-418X AD - Faculty of Sport Sciences, University of Extremadura, 10003 Caceres, Spain. FAU - Gonzalez-Ponce, Inmaculada AU - Gonzalez-Ponce I AUID- ORCID: 0000-0002-7816-7789 AD - Faculty of Teacher Training, University of Extremadura, 10003 Caceres, Spain. LA - eng GR - PID2022-140903NB-I00/Ministerio de Ciencia, Innovacion y Universidades/ GR - FPI-UEx/2023/5/Ministerio de Ciencia, Innovacion y Universidades/ PT - Journal Article DEP - 20260310 PL - Switzerland TA - Brain Sci JT - Brain sciences JID - 101598646 PMC - PMC13023810 OTO - NOTNLM OT - Fitbit OT - executive functions OT - inhibitory control OT - longitudinal study OT - physical activity OT - secondary school OT - sleep duration OT - teenagers COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/03/27 17:38 MHDA- 2026/03/27 17:39 PMCR- 2026/03/10 CRDT- 2026/03/27 11:16 PHST- 2026/02/19 00:00 [received] PHST- 2026/03/06 00:00 [revised] PHST- 2026/03/08 00:00 [accepted] PHST- 2026/03/27 17:39 [medline] PHST- 2026/03/27 17:38 [pubmed] PHST- 2026/03/27 11:16 [entrez] PHST- 2026/03/10 00:00 [pmc-release] AID - brainsci16030302 [pii] AID - brainsci-16-00302 [pii] AID - 10.3390/brainsci16030302 [doi] PST - epublish SO - Brain Sci. 2026 Mar 10;16(3):302. doi: 10.3390/brainsci16030302. PMID- 41891320 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260828 IS - 1601-6343 (Electronic) IS - 1601-6335 (Print) IS - 1601-6335 (Linking) VI - 29 IP - 4 DP - 2026 Aug TI - Facial Growth Patterns and Midpalatal Suture Maturation in Adults: A Retrospective CBCT-Based Observational Study. PG - 708-716 LID - 10.1111/ocr.70118 [doi] AB - OBJECTIVE: To investigate whether facial growth pattern is associated with the maturation stage of the midpalatal suture (MPS) in adults using cone-beam computed tomography (CBCT). MATERIALS AND METHODS: This retrospective study reviewed 300 full-skull CBCT scans acquired between January 2018 and May 2023, of which 120 met the eligibility criteria. Individuals aged 18 years or older were classified according to facial growth pattern (brachyfacial, mesofacial or dolichofacial) using Ricketts' VERT index. Age was categorised into < 30 and >/= 30 years based on clinical evidence suggesting increased frequency of sutural fusion after the third decade of life. Exclusion criteria included craniofacial anomalies, syndromic conditions, systemic or hormonal disorders affecting skeletal growth, impacted teeth, previous maxillary surgery, trauma and inadequate image quality. MPS maturation was assessed using Angelieri's five-stage classification (A-E). Two calibrated examiners independently evaluated all cephalometric and tomographic records. Ordinal multinomial logistic regression was applied to analyse associations between facial growth pattern, age, sex and MPS maturation stage. RESULTS: Facial growth pattern was significantly associated with MPS maturation stage (chi(2) = 20.65, p < 0.001), with dolichofacial individuals more frequently presenting earlier maturation stages (B or C). Age (p = 0.297) and sex (p = 0.870) were not significantly associated with MPS maturation in this adult sample. Reliability analysis demonstrated excellent intra- and inter-examiner agreement (ICC = 0.95; kappa = 0.98). CONCLUSION: Facial growth pattern was associated with MPS maturation stage in adults and may function as an adjunctive diagnostic parameter. Dolichofacial individuals more frequently exhibited earlier stages of sutural maturation, whereas age and sex showed no significant association. Although facial pattern analysis should not replace CBCT evaluation, it may contribute to a more individualised, anatomy-based diagnostic assessment. These findings should be interpreted cautiously due to the cross-sectional design and specific population studied. CI - (c) 2026 The Author(s). Orthodontics & Craniofacial Research published by John Wiley & Sons Ltd. FAU - do Nascimento Silva, Elizabety AU - do Nascimento Silva E AUID- ORCID: 0000-0003-2569-3010 AD - Dentistry Department, Federal University of Paraiba, Paraiba, Brazil. FAU - de Abreu, Nathalie Murielly Rolim AU - de Abreu NMR AUID- ORCID: 0000-0003-0556-9901 AD - Postgraduate Program in Dentistry, Federal University of Paraiba, Paraiba, Brazil. FAU - de Sousa, Frederico Barbosa AU - de Sousa FB AUID- ORCID: 0000-0002-9158-8342 AD - Morphology Department, Federal University of Paraiba, Paraiba, Brazil. FAU - Panzarella, Francine Kuhl AU - Panzarella FK AUID- ORCID: 0000-0002-5650-7711 AD - Oral Radiology Division, Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. FAU - Dos Santos Oliveira, Rudyard AU - Dos Santos Oliveira R AUID- ORCID: 0000-0001-9690-8563 AD - Postgraduate Program in Dentistry, Federal University of Paraiba, Paraiba, Brazil. LA - eng GR - 88887.808604/202300/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ PT - Journal Article PT - Observational Study DEP - 20260327 PL - England TA - Orthod Craniofac Res JT - Orthodontics & craniofacial research JID - 101144387 SB - IM MH - Humans MH - *Cone-Beam Computed Tomography MH - Retrospective Studies MH - Adult MH - Female MH - Male MH - *Maxillofacial Development/physiology MH - *Cranial Sutures/growth & development/diagnostic imaging MH - Cephalometry MH - Adolescent MH - Young Adult MH - *Palate, Hard/growth & development/diagnostic imaging PMC - PMC13485212 OTO - NOTNLM OT - bone maturation OT - cone-beam computed tomography OT - facial growth OT - midpalatal suture OT - miniscrew-assisted maxillary expansion COIS- The authors declare no conflicts of interest. EDAT- 2026/03/27 17:38 MHDA- 2026/08/18 17:37 PMCR- 2026/08/18 CRDT- 2026/03/27 06:33 PHST- 2026/03/05 00:00 [revised] PHST- 2025/12/04 00:00 [received] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/08/18 17:37 [medline] PHST- 2026/03/27 17:38 [pubmed] PHST- 2026/03/27 06:33 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - OCR70118 [pii] AID - 10.1111/ocr.70118 [doi] PST - ppublish SO - Orthod Craniofac Res. 2026 Aug;29(4):708-716. doi: 10.1111/ocr.70118. Epub 2026 Mar 27. PMID- 41890940 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260327 LR - 20260920 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Can physical exercise alleviate social anxiety in junior high school students by improving body image? PG - 1780759 LID - 10.3389/fpsyg.2026.1780759 [doi] LID - 1780759 AB - OBJECTIVE: This study aims to investigate the dynamic relationships between physical exercise (PE), body image (BI), and social anxiety (SA) among Chinese junior high school students, as well as to analyze the mechanism through which PE may alleviate SA by improving BI. METHODS: A total of 851 students (652 males, 391 females) from grades 7 and 8 across five secondary schools in Sichuan, Jiangsu, and Guangdong provinces were selected for this 12-month longitudinal study. Four waves of data were collected using validated questionnaires measuring PE, BI, and SA. The data were analyzed using a random intercept cross-lagged panel model (RI-CLPM). RESULTS: The study revealed the following findings: (1) PE showed significant positive correlations with BI at all four time points (r = 0.308 to 0.463, p < 0.001) and significant negative correlations with SA (r = -0.142 to -0.301, p < 0.001); (2) BI was also significantly negatively correlated with SA (r = -0.138 to -0.313, p < 0.001); (3) PE significantly reduced subsequent SA levels by improving BI. The total effect of the pathway PE(T1) --> BI(T2) --> SA(T3) was -0.301, with a mediation effect of -0.125 (accounting for 41.53% of the total effect). CONCLUSION: This study elucidates the mediating mechanism through which PE alleviates SA by enhancing BI, providing scientific evidence for adolescent mental health interventions. Schools are advised to incorporate strategies in physical education curricula and activities that foster positive BI and social adaptation skills to promote psychological well-being. CI - Copyright (c) 2026 Xing, Yang, Wu, Shao and Zang. FAU - Xing, Sunxuan AU - Xing S AD - School of Sports Training, Chengdu Sport University, Chengdu, China. FAU - Yang, Yang AU - Yang Y AD - School of Sports Training, Chengdu Sport University, Chengdu, China. FAU - Wu, Jingtao AU - Wu J AD - School of Physical Education, Leshan Normal University, Leshan, China. FAU - Shao, Yanhong AU - Shao Y AD - Xiangshui Teacher Development Center, Yancheng, China. FAU - Zang, Wanli AU - Zang W AD - Postgraduate School, Harbin Sport University, Harbin, China. LA - eng PT - Journal Article DEP - 20260311 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC13013369 OTO - NOTNLM OT - body image OT - cross-lagged model OT - longitudinal study OT - mental health OT - physical exercise OT - social anxiety COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/27 07:15 MHDA- 2026/03/27 07:16 PMCR- 2026/03/11 CRDT- 2026/03/27 05:17 PHST- 2026/01/04 00:00 [received] PHST- 2026/01/30 00:00 [revised] PHST- 2026/02/16 00:00 [accepted] PHST- 2026/03/27 07:16 [medline] PHST- 2026/03/27 07:15 [pubmed] PHST- 2026/03/27 05:17 [entrez] PHST- 2026/03/11 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1780759 [doi] PST - epublish SO - Front Psychol. 2026 Mar 11;17:1780759. doi: 10.3389/fpsyg.2026.1780759. eCollection 2026. PMID- 41890874 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260327 LR - 20260813 IS - 2297-055X (Print) IS - 2297-055X (Electronic) IS - 2297-055X (Linking) VI - 13 DP - 2026 TI - Identification of the Hub genes and inhibitors associated with hypertension in children with obesity using WGCNA. PG - 1632570 LID - 10.3389/fcvm.2026.1632570 [doi] LID - 1632570 AB - INTRODUCTION: Childhood obesity is an escalating public health issue linked to comorbidities such as hypertension, which poses significant cardiovascular risks. This research aims to elucidate the molecular pathways connecting obesity to hypertension in pediatric populations, with a focus on the gene S100A9 (S100 Calcium Binding Protein A9), implicated in inflammatory responses and vascular dysfunction. METHODS: We analyzed gene expression data from GSE87493 dataset and performed Weighted Gene Co-expression Network Analysis (WGCNA) to identify the differentially expressed genes (DEGs) and co-expression modules associated with childhood obesity. Functional assays were conducted to investigate the role of S100A9 in vascular endothelial dysfunction. Besides, small molecule inhibitors targeting S100A9 were screened for therapeutic potential. RESULTS: Five DEGs, including S100A9, showed distinct expression patterns in children with obesity. Mechanistically, S100A9 increases reactive oxygen species (ROS) levels and reducing Nitric oxide (NO), thereby impairing endothelial function. Small molecule inhibitor ABR-215757 (Paquinimod) was identified as a promising candidate, enhancing tube formation in the human umbilical vein endothelial cells (HUVECs) and reducing inflammatory markers. CONCLUSION: Targeting S100A9 may restore endothelial function and offer novel therapeutic strategies for obesity-related hypertension in children. More future research should validate these findings through in vivo models and clinical trials to evaluate the efficacy and safety of S100A9 inhibitors in pediatric populations. CI - (c) 2026 Sun, Bai, Liu, Fang, Ma, Yu and Wu. FAU - Sun, Si-Mei AU - Sun SM AD - Department of Pharmacy, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, China. FAU - Bai, Min AU - Bai M AD - Department of Pediatrics, Zhoushan Women and Children Hospital, Zhoushan, Zhejiang, China. FAU - Liu, Ying AU - Liu Y AD - Department of Pharmacy, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, China. FAU - Fang, Qiong-Yan AU - Fang QY AD - Department of Pharmacy, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, China. FAU - Ma, Hai-Jie AU - Ma HJ AD - Laboratory of Cytobiology and Molecular Biology, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, China. FAU - Yu, Ze AU - Yu Z AD - Laboratory of Cytobiology and Molecular Biology, Zhoushan Hospital, Wenzhou Medical University, Zhoushan, Zhejiang, China. FAU - Wu, Fei-Yue AU - Wu FY AD - Department of Pharmacy, Zhoushan Traditional Chinese Medicine Hospital, Zhoushan, Zhejiang, China. LA - eng PT - Journal Article DEP - 20260311 PL - Switzerland TA - Front Cardiovasc Med JT - Frontiers in cardiovascular medicine JID - 101653388 PMC - PMC13013500 OTO - NOTNLM OT - HUVEC OT - WGCNA OT - children with obesity OT - hypertension OT - s100A9 COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/27 07:15 MHDA- 2026/03/27 07:16 PMCR- 2026/03/11 CRDT- 2026/03/27 05:16 PHST- 2025/05/21 00:00 [received] PHST- 2026/02/15 00:00 [revised] PHST- 2026/02/23 00:00 [accepted] PHST- 2026/03/27 07:16 [medline] PHST- 2026/03/27 07:15 [pubmed] PHST- 2026/03/27 05:16 [entrez] PHST- 2026/03/11 00:00 [pmc-release] AID - 10.3389/fcvm.2026.1632570 [doi] PST - epublish SO - Front Cardiovasc Med. 2026 Mar 11;13:1632570. doi: 10.3389/fcvm.2026.1632570. eCollection 2026. PMID- 41890194 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Serum osteocalcin as a novel biomarker for differentiating growth hormone deficiency from idiopathic short stature. PG - 1745971 LID - 10.3389/fendo.2026.1745971 [doi] LID - 1745971 AB - BACKGROUND: The differentiation between Growth Hormone Deficiency (GHD) and Idiopathic Short Stature (ISS) primarily relies on the growth hormone stimulation test (GHST),which is invasive and can cause adverse effects. OBJECTIVE: To evaluate the diagnostic value of bone turnover markers in distinguishing GHD from ISS. METHODS: A cross-sectional study was conducted, enrolling 76 children aged 3-11 years with short stature (37 in the GHD group and 39 in the ISS group). Clinical data including height, weight, bone age, Insulin-like Growth Factor 1(IGF-1), and Peak Growth Hormone (GHP) levels were collected. Eight bone turnover markers were measured: Osteocalcin (OC), beta-C-terminal telopeptide of type I collagen (beta-CTX), 25-Hydroxyvitamin D (25(OH)D), Vitamin D (VitD), Alkaline Phosphatase (ALP), Parathyroid Hormone (PTH), serum Calcium (Ca), and serum Phosphorus (P). Nonparametric tests were used for intergroup comparisons. Logistic regression and Receiver Operating Characteristic (ROC) curve analyses were performed to assess diagnostic efficacy, and Spearman correlation analysis was employed for correlation evaluation. RESULTS: The OC level in the GHD group was significantly lower than that in the ISS group (P < 0.001), while serum P was higher in the GHD group (P < 0.05). Multivariate analysis identified OC as an independent discriminative factor (OR = 182.585, P < 0.001). ROC curve analysis revealed that OC had an area under the curve (AUC) of 0.949, At a cutoff of 1.026 ng/mL, sensitivity was 86.49% and specificity was 100%. Correlation analysis indicated a positive association between OC levels and GHP (r = 0.6, P < 0.05). CONCLUSION: Serum OC shows high diagnostic value for distinguishing GHD from ISS, demonstrating significant clinical utility. CI - Copyright (c) 2026 Wang, Zhou, Wang, Ma, Chen, Yang, Zheng and Wang. FAU - Wang, Yuling AU - Wang Y AD - Kunming First People's Hospital, Affiliated to Kunming Medical University, Kunming, Yunnan, China. FAU - Zhou, Huanzhen AU - Zhou H AD - Kunming First People's Hospital, Affiliated to Kunming Medical University, Kunming, Yunnan, China. FAU - Wang, Hongye AU - Wang H AD - Clinical Medical College of Dali University, Dali, Yunnan, China. FAU - Ma, Jianying AU - Ma J AD - Kunming First People's Hospital, Affiliated to Kunming Medical University, Kunming, Yunnan, China. FAU - Chen, Xingyu AU - Chen X AD - Kunming First People's Hospital, Affiliated to Kunming Medical University, Kunming, Yunnan, China. FAU - Yang, Hongmei AU - Yang H AD - Kunming First People's Hospital, Affiliated to Kunming Medical University, Kunming, Yunnan, China. FAU - Zheng, Hongcun AU - Zheng H AD - Kunming First People's Hospital, Affiliated to Kunming Medical University, Kunming, Yunnan, China. FAU - Wang, Aiping AU - Wang A AD - Kunming First People's Hospital, Affiliated to Kunming Medical University, Kunming, Yunnan, China. LA - eng PT - Journal Article DEP - 20260311 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 RN - 104982-03-8 (Osteocalcin) RN - 0 (Biomarkers) RN - 12629-01-5 (Human Growth Hormone) RN - 0 (BGLAP protein, human) RN - 67763-96-6 (Insulin-Like Growth Factor I) SB - IM MH - Humans MH - *Osteocalcin/blood MH - Female MH - Male MH - *Biomarkers/blood MH - Cross-Sectional Studies MH - Child, Preschool MH - Child MH - *Human Growth Hormone/deficiency MH - Diagnosis, Differential MH - *Growth Disorders/blood/diagnosis MH - ROC Curve MH - Insulin-Like Growth Factor I MH - *Dwarfism, Pituitary/blood/diagnosis PMC - PMC13013015 OTO - NOTNLM OT - bone turnover markers OT - diagnostic markers OT - growth hormone deficiency OT - idiopathic short stature OT - osteocalcin COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/27 07:15 MHDA- 2026/03/27 07:16 PMCR- 2026/03/11 CRDT- 2026/03/27 05:10 PHST- 2025/11/13 00:00 [received] PHST- 2026/01/22 00:00 [revised] PHST- 2026/02/11 00:00 [accepted] PHST- 2026/03/27 07:16 [medline] PHST- 2026/03/27 07:15 [pubmed] PHST- 2026/03/27 05:10 [entrez] PHST- 2026/03/11 00:00 [pmc-release] AID - 10.3389/fendo.2026.1745971 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Mar 11;17:1745971. doi: 10.3389/fendo.2026.1745971. eCollection 2026. PMID- 41888969 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260627 LR - 20260813 IS - 0778-7367 (Print) IS - 2049-3258 (Electronic) IS - 0778-7367 (Linking) VI - 84 IP - 1 DP - 2026 Mar 26 TI - Study protocol for Valor Barroso: a mixed-method approach to dietary-physical activity patterns in Barroso, Portugal. LID - 10.1186/s13690-026-01900-8 [doi] LID - 101 AB - AIM: This community-based mixed-methods study aims to evaluate the dietary habits and physical activity patterns of the Barroso population in northern Portugal. METHODS: This study was divided into two phases. The quantitative phase will be a cross-sectional study involving 416 participants from different age groups, including children, adolescents, adults, and elderly individuals. Sociodemographic and clinical, including anthropometric measurements, blood pressure, and quality of life, will be collected. Physical activity will be assessed wGT3X+ Actigraph accelerometers and validated questionnaires, whereas dietary habits will be evaluated via food frequency questionnaires, 24-hour dietary recalls, and food diaries. In the qualitative phase, participants will be selected through stratified sampling and ethnographic analysis will be conducted through observations and semi-structured interviews to explore the cultural, social, and environmental factors influencing dietary habits and physical activity in the local population. DISCUSSION: By integrating objective measures of physical activity and diet, such as accelerometers and validated questionnaires, with qualitative data on cultural and traditional practices, this study aims to provide a more comprehensive understanding of lifestyle behaviors in the region and their associations with health. Additionally, the study investigated how geographical, socioeconomic, and cultural contexts influence these dietary and physical activity behaviors. The conclusions drawn will help develop public health interventions to improve health outcomes in rural communities and will contribute to the development of more effective strategies for similar populations. FAU - Cortez-Ribeiro, Anna Carolina AU - Cortez-Ribeiro AC AD - CIMO, LA SusTEC, Instituto Politecnico de Braganca, Campus de Santa Apolonia, Braganca, 5300- 253, Portugal. AD - Centro de Investigacao em Actividade Fisica Saude e Lazer (CIAFEL), Faculdade de Desporto, Universidade do Porto, Rua Dr. Placido da Costa, 91, Porto, 4200-450, Portugal. FAU - Ribeiro, Jose Carlos AU - Ribeiro JC AD - Centro de Investigacao em Actividade Fisica Saude e Lazer (CIAFEL), Faculdade de Desporto, Universidade do Porto, Rua Dr. Placido da Costa, 91, Porto, 4200-450, Portugal. AD - Laboratorio para a Investigacao Integrativa e Translacional em Saude Populacional (ITR), Universidade do Porto, Rua das Taipas, 135, Porto, 4050-600, Portugal. FAU - Alves, Maria Jose AU - Alves MJ AD - Centro de Valorizacao e Transferencia de Tecnologia da Agua, AquaValor, Rua Dr. Julio Martins, 1, Chaves, 5400-342, Portugal. AD - LiveWell - Research Centre for Active Living & Wellbeing, Instituto Politecnico de Braganca, Campus de Santa Apolonia, Braganca, 5300- 253, Portugal. FAU - Ferro-Lebres, Vera AU - Ferro-Lebres V AD - CIMO, LA SusTEC, Instituto Politecnico de Braganca, Campus de Santa Apolonia, Braganca, 5300- 253, Portugal. vferrolebres@ipb.pt. LA - eng GR - PRT/BD/154584/2023/Fundacao para a Ciencia e a Tecnologia/ GR - UIDB/00617/2020 (DOI: 10.54499/UIDB/00617/2020) and UIDP/00617/2020 (DOI: 10.54499/UIDP/00617/20);/Fundacao para a Ciencia e a Tecnologia/ GR - CIMO, UIDB/00690/2020 (DOI: 10.54499/UIDB/00690/2020) and UIDP/00690/2020 (DOI: 10.54499/UIDP/00690/2020); SusTEC, LA/P/0007/2020 (DOI: 10.54499/LA/P/0007/2020)/Fundacao para a Ciencia e a Tecnologia/ PT - Journal Article DEP - 20260326 PL - England TA - Arch Public Health JT - Archives of public health = Archives belges de sante publique JID - 9208826 PMC - PMC13147682 OTO - NOTNLM OT - Dietary patterns OT - Lifestyle OT - Physical activity OT - Public health OT - Rural population COIS- Declarations. Ethical approval and consent to participate: This study was approved by the Ethics Committee of the Instituto Politecnico de Braganca (P545795-R674918-D2059383). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Consent for participating will be obtained from all participants after data collection. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/27 07:15 MHDA- 2026/03/27 07:16 PMCR- 2026/03/26 CRDT- 2026/03/27 01:14 PHST- 2025/09/30 00:00 [received] PHST- 2026/03/12 00:00 [accepted] PHST- 2026/03/27 07:16 [medline] PHST- 2026/03/27 07:15 [pubmed] PHST- 2026/03/27 01:14 [entrez] PHST- 2026/03/26 00:00 [pmc-release] AID - 10.1186/s13690-026-01900-8 [pii] AID - 1900 [pii] AID - 10.1186/s13690-026-01900-8 [doi] PST - epublish SO - Arch Public Health. 2026 Mar 26;84(1):101. doi: 10.1186/s13690-026-01900-8. PMID- 41888921 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 1475-9276 (Electronic) IS - 1475-9276 (Linking) VI - 25 IP - 1 DP - 2026 Mar 27 TI - Preventive infrastructure and childhood health equity in Israel: socioeconomic and ethnic disparities in playground access and swimming instruction. LID - 10.1186/s12939-026-02826-x [doi] LID - 120 AB - BACKGROUND: Despite universal health coverage and longstanding child-safety initiatives, socioeconomic and ethnic inequalities in childhood injury remain pronounced in Israel. Unintentional childhood injuries (UCI) function as a proxy for health inequity, reflecting structural gaps in preventive infrastructure and access to safe environments. METHODS: This study examines two case studies that illustrate how differential public investment contributes to unequal injury risks: (1) public playgrounds availability, and (2) participation in school-based swimming lessons. Both are analyzed within a social-determinants-of-health framework, emphasizing the interaction of environment, education, and municipal capacity. Data on fatal childhood injuries in public spaces and drowning incidents were drawn from Beterem Safe Kids Israel's national media-based mortality database (2008-2025). Playground availability was assessed through triangulated sources, including OpenStreetMap, field validation, and Standards Institution of Israel records. Swimming-participation data were obtained from Ministry of Education responses to Freedom of Information requests for 2022-2023. Associations between infrastructure and training and child mortality were tested using Spearman's rank correlation. RESULTS: Across 62 municipalities with child populations above 10,000, a significant positive correlation was found between children per playground and UCI (Unintentional Child Injury) mortality in public spaces (rho = 0.290, p < 0.05). Swimming participation displayed a inverse, though non-significant, relationship with drowning mortality (rho = - 0.357, p = 0.08). Participation inequalities were substantial: only 25% of children from low-SES clusters (1-3) and 20.5% of Arab children participated in swimming instruction, compared with 60% in affluent and Jewish municipalities. Between 2021 and 2025, Arab children were more than twice as likely to die from drowning as Jewish children (rate ratio = 2.43, chi(2) = 14.83, p < 0.001). CONCLUSIONS: These findings point to a shared structural mechanism behind injury inequalities: persistent underinvestment and institutional barriers that restrict access to preventive infrastructure in low-income and minority municipalities. Although playgrounds and swimming lessons are distinct domains, both exemplify how inequitable distribution of safety-enhancing resources produces measurable health risks. Addressing these gaps requires coordinated policy reforms that integrate public health, education, and urban planning; establish equity-weighted funding for preventive infrastructure; and institutionalize monitoring of child-safety environments. Equitable investment in prevention is essential for reducing injury and advancing child health equity in Israel. CI - (c) 2026. The Author(s). FAU - Agam, Aviad AU - Agam A AD - Beterem Safe Kids Israel, Petah Tikva, Israel. aviada@beterem.org. FAU - Barnea, Royi AU - Barnea R AD - Assuta Health Services Research Institute, Tel Aviv, Israel. AD - School of Health Systems Management at Netanya Academic College, Netanya, Israel. FAU - Godler, Yigal AU - Godler Y AD - Beterem Safe Kids Israel, Petah Tikva, Israel. LA - eng PT - Journal Article DEP - 20260327 PL - England TA - Int J Equity Health JT - International journal for equity in health JID - 101147692 SB - IM MH - Humans MH - Israel/epidemiology MH - *Swimming/education MH - Socioeconomic Disparities in Health MH - Child MH - *Health Equity MH - Drowning/mortality MH - Male MH - Wounds and Injuries/prevention & control MH - Female MH - *Child Health MH - Child, Preschool MH - Socioeconomic Factors MH - Ethnicity/statistics & numerical data MH - Play and Playthings PMC - PMC13147852 OTO - NOTNLM OT - Child injury OT - Drowning OT - Health inequality OT - Israel OT - Playgrounds OT - Preventive infrastructure OT - Social determinants of health COIS- Declarations. Ethics approval and consent to participate: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/27 07:14 MHDA- 2026/05/06 06:38 PMCR- 2026/03/27 CRDT- 2026/03/27 01:11 PHST- 2025/12/08 00:00 [received] PHST- 2026/03/18 00:00 [accepted] PHST- 2026/05/06 06:38 [medline] PHST- 2026/03/27 07:14 [pubmed] PHST- 2026/03/27 01:11 [entrez] PHST- 2026/03/27 00:00 [pmc-release] AID - 10.1186/s12939-026-02826-x [pii] AID - 2826 [pii] AID - 10.1186/s12939-026-02826-x [doi] PST - epublish SO - Int J Equity Health. 2026 Mar 27;25(1):120. doi: 10.1186/s12939-026-02826-x. PMID- 41888890 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260901 IS - 2046-4053 (Electronic) IS - 2046-4053 (Linking) VI - 15 IP - 1 DP - 2026 Mar 26 TI - Clinical assessment and biomarkers for the detection of bacterial community-acquired pneumonia in children and adults: a protocol for systematic review of diagnostic accuracy. LID - 10.1186/s13643-026-03166-1 [doi] LID - 154 AB - BACKGROUND: Community-acquired pneumonia (CAP) is defined as an infection of the pulmonary parenchyma acquired in the community and outside the hospital setting. CAP is generally diagnosed based on clinical parameters and chest radiography, with biomarkers increasingly used to support diagnostic decisions. Our review aims to synthesise evidence on the diagnosis of bacterial CAP using clinical assessments and biomarkers and to guide evidence-based national antibiotic guidelines for bacterial CAP in India. Our primary objective is to determine the diagnostic accuracy of clinical criteria (symptoms, examination findings, or clinical scoring systems) and chest X-rays with and without serum biomarkers for detecting bacterial CAP in children and adults with presumptive signs and symptoms of pneumonia. We also aim to investigate potential sources of heterogeneity in the diagnostic accuracy of the aforementioned index tests in relation to covariates such as the healthcare settings, HIV status, malnutrition, and comorbidities. METHODS: We will perform a systematic search of electronic databases without language and geographical restriction and bibliography mining. We will only include prospective and retrospective cross-sectional and cohort studies and Randomized Control trials. We will exclude case reports, conference abstracts, reviews, and studies with a case-control design. We will also include studies that provide or allow the derivation of diagnostic accuracy data. Participants from all healthcare settings with a presumptive diagnosis of CAP will be included. The QUADAS-2 tool will be used to ascertain the methodological quality of the selected studies. We will perform analyses of data for children and adults separately. Bivariate model will be used for meta-analysis to estimate summary sensitivity and specificity wherever possible. Certainty of evidence will be assessed using the GRADE approach (Grading of Recommendations Assessment, Development, and Evaluation) for diagnostic test accuracy studies. DISCUSSION: Our review will evaluate the diagnostic accuracy of clinical criteria, with and without biomarkers, for diagnosing bacterial CAP in children and adults. This will inform antibiotic guidelines in India and similar resource-limited settings. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42024619430 and CRD42024620335. CI - (c) 2026. The Author(s). FAU - Daniel, Jefferson AU - Daniel J AD - Department of Pulmonary Medicine, Christian Medical College, Vellore, India. FAU - Sathya Narayanan, Mukesh Kumar AU - Sathya Narayanan MK AD - Department of Epidemiology, ICMR-National Institute for Research in Tuberculosis, Chennai, India. FAU - Srinivasalu, Vignes Anand AU - Srinivasalu VA AD - Department of Clinical Research, ICMR-National Institute for Research in Tuberculosis, Chennai, India. FAU - Bhaskar, Adhin AU - Bhaskar A AD - Department of Statistics, ICMR-National Institute for Research in Tuberculosis, Chennai, India. FAU - Suresh, Sharon AU - Suresh S AD - Department of Clinical Research, ICMR-National Institute for Research in Tuberculosis, Chennai, India. FAU - Daniel, Bella Devaleenal AU - Daniel BD AD - Department of Clinical Research, ICMR-National Institute for Research in Tuberculosis, Chennai, India. FAU - Ramraj, Balaji AU - Ramraj B AD - Department of Clinical Research, ICMR-National Institute for Research in Tuberculosis, Chennai, India. AD - Faculty of Medical Research, Academy of Scientific and Innovative Research, Ghaziabad, India. FAU - Nair, Dina AU - Nair D AD - Department of Clinical Research, ICMR-National Institute for Research in Tuberculosis, Chennai, India. FAU - James, Ranjit Immanuel AU - James RI AD - Department of Forensic Medicine and Toxicology, Christian Medical College, Vellore, India. FAU - Vasudevan, Sudharsan AU - Vasudevan S AD - National Tuberculosis Elimination Program, World Health Organization, New Delhi, India. FAU - Velayutham, Banurekha AU - Velayutham B AD - Department of Clinical Research, ICMR-National Institute for Research in Tuberculosis, Chennai, India. FAU - Inbaraj, Leeberk Raja AU - Inbaraj LR AUID- ORCID: 0000-0001-8642-1348 AD - Department of Clinical Research, ICMR-National Institute for Research in Tuberculosis, Chennai, India. leeberk2003@gmail.com. AD - Faculty of Medical Research, Academy of Scientific and Innovative Research, Ghaziabad, India. leeberk2003@gmail.com. LA - eng GR - Technical Resource Centre/Department of Health Research, India/ GR - Centre for Evidence-based guidelines/Department of Health Research, India/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260326 PL - England TA - Syst Rev JT - Systematic reviews JID - 101580575 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Systematic Reviews as Topic MH - *Community-Acquired Pneumonia/diagnosis MH - *Biomarkers/blood MH - Child MH - *Pneumonia, Bacterial/diagnosis MH - Adult MH - India MH - Community-Acquired Infections/diagnosis MH - Research Design MH - Sensitivity and Specificity PMC - PMC13141618 OTO - NOTNLM OT - Biomarkers OT - C-reactive protein OT - CXR OT - Community-acquired pneumonia OT - Culture OT - Systematic review COIS- Declarations. Ethics approval and consent to participate: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/03/27 07:15 MHDA- 2026/05/05 06:32 PMCR- 2026/03/26 CRDT- 2026/03/27 01:09 PHST- 2025/01/29 00:00 [received] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/05/05 06:32 [medline] PHST- 2026/03/27 07:15 [pubmed] PHST- 2026/03/27 01:09 [entrez] PHST- 2026/03/26 00:00 [pmc-release] AID - 10.1186/s13643-026-03166-1 [pii] AID - 3166 [pii] AID - 10.1186/s13643-026-03166-1 [doi] PST - epublish SO - Syst Rev. 2026 Mar 26;15(1):154. doi: 10.1186/s13643-026-03166-1. PMID- 41888889 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260430 LR - 20260813 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2026 Mar 27 TI - Investigation of virtual multi-family therapy for adolescent anorexia nervosa: feasibility and acceptability. LID - 10.1186/s40337-026-01575-0 [doi] LID - 97 AB - BACKGROUND: Multi-Family Therapy for Anorexia Nervosa (MFT-AN) unites families navigating similar difficulties to promote more rapid recovery for adolescents with eating disorders. Designed as a collaborative, group-based intervention, MFT-AN shows promise for enhancing clinical outcomes while also broadening access to evidence-based care. This pilot study seeks to investigate the feasibility and acceptability of MFT-AN adapted to a virtual format. METHODS: Seventy-seven adolescents and 130 parents enrolled in this single-arm, pilot study. Measures included treatment interest, eligibility, scheduling, enrollment, and completion; surveys assessing acceptability, satisfaction, and perceived effectiveness; patient characteristics; eating disorder symptoms; and body mass index. RESULTS: There was a high level of interest in virtual MFT-AN. Of recruited and eligible families, nearly half scheduled a baseline assessment. Both attendance and study completion were high. Participants generally expressed acceptability of the virtual format, which still fostered connection amongst the group members. Descriptively, effect size changes from baseline to 12 months for global eating disorder symptoms and percent median BMI were medium-to-large. CONCLUSIONS: Preliminary data suggest that the virtual MFT-AN program is feasible and acceptable. Though larger effectiveness trials are needed, this research lays the foundation for one method of increasing access and enhancing outcomes in evidence-based treatment for adolescent anorexia nervosa. Trial registration This study was registered with ClinicalTrials.gov (ID NCT06203418). CI - (c) 2026. The Author(s). FAU - Arbit, Sarah E AU - Arbit SE AUID- ORCID: 0000-0003-1288-4977 AD - Chicago Center for Evidence Based Treatment, 25 East Washington Street Unit 1613, Chicago, IL, 60602, USA. sbroner@luc.edu. AD - Loyola University Chicago, Chicago, IL, USA. sbroner@luc.edu. FAU - Anderson, Kristen AU - Anderson K AUID- ORCID: 0000-0002-6958-7618 AD - Chicago Center for Evidence Based Treatment, 25 East Washington Street Unit 1613, Chicago, IL, 60602, USA. FAU - Desai, Sara AU - Desai S AD - Chicago Center for Evidence Based Treatment, 25 East Washington Street Unit 1613, Chicago, IL, 60602, USA. FAU - Bernstein, Karen AU - Bernstein K AD - University of Chicago Medicine, Chicago, IL, USA. LA - eng SI - ClinicalTrials.gov/NCT06203418 PT - Journal Article DEP - 20260327 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC13126919 OAB - There are well-researched and evidence-based treatment options for adolescents with anorexia nervosa, yet many adolescents who receive front-line interventions do not fully recover. There is a great need for additional treatment options that can expedite the recovery process, improve outcomes, and expand access for families affected by anorexia nervosa. One such intervention is Multi-Family Therapy for adolescent Anorexia Nervosa (MFT-AN). The current study evaluates whether MFT-AN delivered in a virtual format is a practical and satisfactory treatment option for families. Results showed that the model was generally feasible and acceptable, carving the path forward for larger effectiveness trials. OABL- eng OTO - NOTNLM OT - Acceptability OT - Adolescent OT - Anorexia nervosa OT - Feasibility OT - Multi-family therapy OT - Virtual COIS- Declarations. Human ethics and consent to participate: The study was approved by the University of Illinois Chicago's Institutional Review Board. Consent was obtained from parents, and assent was obtained from adolescents to enroll in the intervention. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/27 07:15 MHDA- 2026/03/27 07:16 PMCR- 2026/03/27 CRDT- 2026/03/27 01:09 PHST- 2025/07/30 00:00 [received] PHST- 2026/03/06 00:00 [accepted] PHST- 2026/03/27 07:16 [medline] PHST- 2026/03/27 07:15 [pubmed] PHST- 2026/03/27 01:09 [entrez] PHST- 2026/03/27 00:00 [pmc-release] AID - 10.1186/s40337-026-01575-0 [pii] AID - 1575 [pii] AID - 10.1186/s40337-026-01575-0 [doi] PST - epublish SO - J Eat Disord. 2026 Mar 27;14(1):97. doi: 10.1186/s40337-026-01575-0. PMID- 41888252 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 27 TI - Risk assessment for type 2 diabetes mellitus and its association with knowledge and health beliefs among university students in three Arab countries. LID - 10.1038/s41598-026-41511-5 [doi] LID - 10367 AB - Type 2 diabetes mellitus (T2DM) is a growing concern in the Arab world, with university students increasingly at risk due to lifestyle factors. This study aims to assess T2DM risk, knowledge, and beliefs among university students aged >/= 18 years in Egypt, Saudi Arabia, and Yemen. A multinational, cross-sectional study was conducted from January to April 2025 among university students aged >/= 18 years in Egypt (lower-middle-income), Saudi Arabia (high-income), and Yemen (low-income). A multistage, stratified purposive sampling technique was used to recruit students equally from medical and non-medical faculties in at least three universities per country. Data were collected via structured, interview-based questionnaires consisting of four components: (1) socio-demographic and anthropometric data; (2) the Diabetes Knowledge Questionnaire-18 (DKQ-18); (3) the Health Belief Model Scale (HBMS); and (4) the validated Arabic version of the Australian type 2 diabetes risk assessment tool (AUSDRISK). Among 2787 university students, the mean age was 21.0 years, with the majority being female (74.9%), and enrolled in medical faculties (58.2%). Diabetes knowledge was significantly higher in Egyptians (72.6% with good knowledge) compared to Saudis (63.9%) and Yemenis (59.8%) (p < 0.001). Health beliefs followed a similar trend, while diabetes risk was significantly higher among Yemeni students (22.0% with severe risk; p < 0.001). Multiple regression analysis revealed that a higher academic year was a positive predictor of both diabetes knowledge (beta = 0.155, p < 0.001) and health beliefs (beta = 0.152, p < 0.001), and was negatively associated with diabetes risk (beta = - 0.061, p < 0.001). Medical faculty enrollment was also positively associated with knowledge (beta = - 0.411 for non-medical faculty, p < 0.001) and beliefs (beta = - 0.228 for non-medical faculties, p < 0.001). Parental education and income were positively associated with knowledge and beliefs. Specifically, father's higher education predicted greater knowledge (beta = 0.047, p < 0.001), and household income was a significant predictor of both knowledge (beta = 0.042, p < 0.001) and beliefs (p < 0.001). In contrast, diabetes risk was independently associated with male gender (beta = 0.305, p < 0.001), older age (beta = 0.123, p < 0.001), higher BMI (beta = 0.284, p < 0.001), and Yemeni nationality (beta = 0.080, p < 0.001). Marked differences in diabetes risk, knowledge, and beliefs were observed among students from the three countries. Interventions targeting high-risk groups are essential to improve diabetes awareness and prevention in young adults. Countries like Yemen may benefit from urgent preventive measures, while countries with moderate risk profiles may focus on health promotion and sustained education to avert future disease burdens. FAU - Ahmed, Hebatalla Abdelmaksoud Abdelmonsef AU - Ahmed HAA AUID- ORCID: 0000-0002-1882-6623 AD - Public Health & Community Medicine Department, Faculty of Medicine, Kafr-Elsheikh University, Kafr El Sheikh, Egypt. Heba_Abdelmasoud@med.kfs.edu.eg. FAU - Yousef, Ahmed AU - Yousef A AD - Public Health & Community Medicine Department, Damietta Faculty of Medicine, Al-Azhar University, Cairo, Egypt. FAU - Abdelwahab, Shady Mohamed AU - Abdelwahab SM AD - Faculty of Medicine, Kafr-Elsheikh University, Kafr El Sheikh, Egypt. FAU - Youssef, Mohamed Adel AU - Youssef MA AD - Faculty of Medicine, Kafr-Elsheikh University, Kafr El Sheikh, Egypt. FAU - Elnozahy, Samah Shalaby AU - Elnozahy SS AD - Faculty of Medicine, Kafr-Elsheikh University, Kafr El Sheikh, Egypt. FAU - Almater, Reema Saeed AU - Almater RS AD - Faculty of Medicine, King Khalid University, El-Qassem, Kingdom of Saudi Arabia. FAU - Saddah, Lamia Ahmed AU - Saddah LA AD - Faculty of Medicine, King Khalid University, El-Qassem, Kingdom of Saudi Arabia. FAU - Al-Dhawi, Methqal AU - Al-Dhawi M AUID- ORCID: 0009-0009-7450-036X AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Al-Matari, Noor Ebrahim Naji AU - Al-Matari NEN AD - Faculty of Medicine, Al-azhar University, Cairo, Egypt. FAU - Al-Azab, Mohammed AU - Al-Azab M AUID- ORCID: 0009-0000-0430-9767 AD - Faculty of Medicine, Sana'a University, Sana'a, Yemen. FAU - Shiba, Hoda Ali Ahmed AU - Shiba HAA AUID- ORCID: 0000-0001-8147-3034 AD - Public Health & Community Medicine Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt. LA - eng PT - Journal Article DEP - 20260327 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/epidemiology MH - Female MH - Male MH - *Health Knowledge, Attitudes, Practice MH - Universities MH - *Students/psychology MH - Young Adult MH - Cross-Sectional Studies MH - Egypt/epidemiology MH - Risk Assessment MH - Saudi Arabia/epidemiology MH - Surveys and Questionnaires MH - Adult MH - Yemen/epidemiology MH - Risk Factors MH - Adolescent MH - Middle Eastern People MH - Arabs PMC - PMC13031495 OTO - NOTNLM OT - Arab countries OT - Diabetes knowledge AUSDRISK OT - Health beliefs OT - Type 2 diabetes OT - University students COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical considerations: The study was approved by the Damietta Faculty of Medicine IRB at Azhar University, Egypt (Study ID: DFM-IRB 00012367-25-05-001), and by the Faculty of Medicine & Health Sciences IRB at Sana'a University, Republic of Yemen (Study ID: 2025 (4) 8). In addition, official permissions were obtained from the deans of the participating faculties in Egypt, Yemen, and Saudi Arabia prior to data collection. The study was executed by the ethical standards laid down in the 1964 Declaration of Helsinki and its later modifications. Informed consent was obtained from all the subjects involved in the study. All participants were given information on the study's purpose, anonymity, confidentiality, voluntary participation, and privacy statements. Confidentiality had been emphasized throughout the study period. EDAT- 2026/03/27 07:15 MHDA- 2026/06/28 04:09 PMCR- 2026/03/27 CRDT- 2026/03/27 00:25 PHST- 2025/07/12 00:00 [received] PHST- 2026/02/20 00:00 [accepted] PHST- 2026/06/28 04:09 [medline] PHST- 2026/03/27 07:15 [pubmed] PHST- 2026/03/27 00:25 [entrez] PHST- 2026/03/27 00:00 [pmc-release] AID - 10.1038/s41598-026-41511-5 [pii] AID - 41511 [pii] AID - 10.1038/s41598-026-41511-5 [doi] PST - epublish SO - Sci Rep. 2026 Mar 27;16(1):10367. doi: 10.1038/s41598-026-41511-5. PMID- 41887121 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 1878-5506 (Electronic) IS - 1389-9457 (Print) IS - 1389-9457 (Linking) VI - 143 DP - 2026 Jul TI - Biphasic sleep is a feature of sleep disturbance in SYNGAP1-RD. PG - 108908 LID - S1389-9457(26)00147-4 [pii] LID - 10.1016/j.sleep.2026.108908 [doi] AB - STUDY OBJECTIVES: Sleep problems are common in children with SYNGAP1-Related Disorder (SYNGAP1-RD). The use of devices that objectively estimate sleep are complicated by co-occurring sensory disorders in this population. We examined the feasibility and validity of wrist actigraphy to examine sleep and rest-activity rhythms (RAR). METHODS: Data from five children with SYNGAP1-RD and 42 typically developing children were analyzed. All children were asked to wear the Actiwatch-2 for 14 continuous days and caregivers were asked to complete a sleep diary and the Children Sleep Health Questionnaire (CSHQ). Parametric (alpha, beta, acrophase, amplitude, up/down mesor, mesor), nonparametric (intradaily variability, interdaily stability, M10/L5 and relative amplitude), and sleep metrics-total sleep time (TST), wake after sleep onset (WASO), fragmentation index (restlessness throughout the rest period), the time of sleep bout onset, the number, and duration of sleep bouts, and the number and duration of wake bouts-were analyzed. RESULTS: In children with SYNGAP1-RD, sleep bouts were distributed across the day and night and were consistent with a higher alpha. Fewer sleep bouts occurred in the early morning aligning with parent report of early morning arousal. Although there was no difference in average TST, children with SYNGAP1-RD, had fewer sleep and wake bouts that were longer in duration. Additionally, they had greater WASO and higher fragmentation index, the latter was a strong predictor of subjects with SYNGAP1-RD. CONCLUSION: Actigraphy provides an objective measure of sleep that aligns with RAR, is consistent with parent report, and provides an ethological approach to monitoring sleep in children with SYNGAP1-RD. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Doucoure, Aida AU - Doucoure A AD - Neurology and Developmental Medicine, Kennedy Krieger Institute, 707 N Broadway, 21205, Baltimore, MD, USA. FAU - Patel, Het AU - Patel H AD - Neurology and Developmental Medicine, Kennedy Krieger Institute, 707 N Broadway, 21205, Baltimore, MD, USA. FAU - Abboud, Mark A AU - Abboud MA AD - Departments of Neurology, Neuroscience and Psychiatry & Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. FAU - Sperry, Alice AU - Sperry A AD - Center for Neurodevelopmental and Imaging Research (CNIR), Kennedy Krieger Institute Baltimore Maryland, USA. FAU - Wanigatunga, Sarah K AU - Wanigatunga SK AD - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 2024 E. Monument St., Rm B309, Baltimore, MD, 21205, USA. FAU - Crocetti, Deana AU - Crocetti D AD - Center for Neurodevelopmental and Imaging Research (CNIR), Kennedy Krieger Institute Baltimore Maryland, USA. FAU - Volk, Heather AU - Volk H AD - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 2024 E. Monument St., Rm B309, Baltimore, MD, 21205, USA. FAU - Spira, Adam P AU - Spira AP AD - Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, 2024 E. Monument St., Rm B309, Baltimore, MD, 21205, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 707 N Broadway, 21205, Baltimore, MD, USA; Johns Hopkins Center on Aging and Health, 2024 E. Monument Street, 21205, Baltimore, MD, USA. FAU - Mostofsky, Stewart H AU - Mostofsky SH AD - Department of Neurology Johns Hopkins University School of Medicine, USA; Center for Neurodevelopmental and Imaging Research (CNIR), Kennedy Krieger Institute Baltimore Maryland, USA; Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 707 N Broadway, 21205, Baltimore, MD, USA. FAU - Krishnan, Vaishnav AU - Krishnan V AD - Departments of Neurology, Neuroscience and Psychiatry & Behavioral Sciences, Baylor College of Medicine, Houston, TX, USA. FAU - Smith-Hicks, Constance AU - Smith-Hicks C AD - Neurology and Developmental Medicine, Kennedy Krieger Institute, 707 N Broadway, 21205, Baltimore, MD, USA; Department of Neurology Johns Hopkins University School of Medicine, USA. Electronic address: hicksc@kennedykrieger.org. LA - eng GR - K08 NS110924/NS/NINDS NIH HHS/United States GR - P50 HD103538/HD/NICHD NIH HHS/United States GR - R01 NS113140/NS/NINDS NIH HHS/United States GR - R01 NS131399/NS/NINDS NIH HHS/United States PT - Journal Article DEP - 20260320 PL - Netherlands TA - Sleep Med JT - Sleep medicine JID - 100898759 RN - 0 (ras GTPase-Activating Proteins) RN - 0 (SYNGAP1 protein, human) SB - IM MH - Humans MH - Actigraphy/methods MH - Female MH - Male MH - *Sleep Wake Disorders/physiopathology/genetics MH - Child MH - Sleep Duration MH - *ras GTPase-Activating Proteins/genetics MH - Surveys and Questionnaires MH - *Sleep/physiology PMC - PMC13288264 MID - NIHMS2161377 OTO - NOTNLM OT - Actigraphy OT - Nonparametric OT - Parametric OT - Rest-activity-rhythms OT - SYNGAP1-RD OT - Sleep disturbances COIS- Declaration of competing interest Adam Spira has served as a consultant to Sequoia Neurovitality, BellSant, Inc., Amissa, Inc., and Synaptic Health, LLC. EDAT- 2026/03/27 01:10 MHDA- 2026/04/26 05:13 PMCR- 2026/06/23 CRDT- 2026/03/26 19:14 PHST- 2026/02/18 00:00 [received] PHST- 2026/03/17 00:00 [revised] PHST- 2026/03/19 00:00 [accepted] PHST- 2026/04/26 05:13 [medline] PHST- 2026/03/27 01:10 [pubmed] PHST- 2026/03/26 19:14 [entrez] PHST- 2026/06/23 00:00 [pmc-release] AID - S1389-9457(26)00147-4 [pii] AID - 10.1016/j.sleep.2026.108908 [doi] PST - ppublish SO - Sleep Med. 2026 Jul;143:108908. doi: 10.1016/j.sleep.2026.108908. Epub 2026 Mar 20. PMID- 41886938 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260722 IS - 1873-6297 (Electronic) IS - 0001-6918 (Linking) VI - 265 DP - 2026 May TI - Effectiveness of yoga training program as a pre-exercise activity on sport anxiety and athletic mental energy in adolescent football players. PG - 106690 LID - S0001-6918(26)00491-9 [pii] LID - 10.1016/j.actpsy.2026.106690 [doi] AB - This study examined whether embedding a brief pre-exercise yoga routine into warm-ups relates to lower sport anxiety and higher athletic mental energy in Chinese adolescent football players, and whether these links operate through mindfulness in sport and vary by weekly training load. In a multi-site sample (N = 468; Wuhan, Hangzhou, Nanjing, Xi'an), athletes completed validated instruments: Sport Anxiety Scale-2, Athletic Mental Energy Scale, Mindfulness Inventory for Sport, Yoga Self-Efficacy Scale, and a short form of interoceptive/body awareness; pre-exercise yoga engagement was modeled formatively (frequency, duration, adherence, intensity), and weekly training load was indexed as seven-day session-RPE x minutes. SmartPLS (v4) was used for PLS-SEM with 5000 bootstraps. The measurement model showed strong reliability and validity (composite reliability >/=0.91; AVE >/= 0.58; HTMT <0.85; Fornell-Larcker satisfied; full-collinearity VIFs <3.3). Pre-exercise yoga practice was also linked with reduced sport anxiety (beta = -0.16, p = 0.003), and increased athletic mental energy (2 = 0.14, p = 0.005); yoga self-efficacy was more strongly linked (2 = -0.20, and 2 = 0.24, both p = 0.001), and lower interoceptive/body awareness was more weakly correlated (2 = -0.11 and 2 = 0.12, both = 0.027). The indirect relationships between the predictors and the outcomes of mindfulness in sport were also significantly large, which is in line with the hypothesized mechanistic pattern. The weekly training load moderated a number of engagement and self-efficacy associations (|human| > Some associations between them were stronger under heavier load (=0.07-0.09, p = 0.048). These results indicate the existence of warm-up-compatible, formatively specified yoga exposure and practically significant load boundary, yet are still consistent with the cross-sectional design of the study... Demographic covariates were non-significant. The study's novelty lies in a warm-up-compatible, formatively specified yoga exposure, a single mechanistic mediator, and a practical load boundary, offering a scalable pathway to reduce anxiety and enhance mental energy without extending training time. CI - Copyright (c) 2024. Published by Elsevier B.V. FAU - Yu, Qun AU - Yu Q AD - School of Physical Education, Yancheng Teachers University, Yancheng, 224000, China. Electronic address: yuq01@yctu.edu.cn. FAU - Liu, Zheng AU - Liu Z AD - School of Education, Anshun University, Anshun, 561000, China. Electronic address: Qunyu.yq@163.com. LA - eng PT - Journal Article DEP - 20260325 PL - Netherlands TA - Acta Psychol (Amst) JT - Acta psychologica JID - 0370366 SB - IM MH - China MH - *Soccer/psychology MH - *Yoga/psychology MH - *Performance Anxiety/prevention & control/psychology MH - *Athletic Performance/psychology MH - *Athletes/psychology MH - Humans MH - Male MH - Adolescent MH - Mindfulness MH - Exercise/psychology OTO - NOTNLM OT - Adolescent football players OT - Athletic mental energy OT - Mindfulness in sport OT - Pre-exercise yoga OT - Sport anxiety COIS- Declaration of competing interest The authors declare no conflict of interest. EDAT- 2026/03/27 01:10 MHDA- 2026/04/19 17:46 CRDT- 2026/03/26 19:06 PHST- 2025/09/04 00:00 [received] PHST- 2026/02/24 00:00 [revised] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/04/19 17:46 [medline] PHST- 2026/03/27 01:10 [pubmed] PHST- 2026/03/26 19:06 [entrez] AID - S0001-6918(26)00491-9 [pii] AID - 10.1016/j.actpsy.2026.106690 [doi] PST - ppublish SO - Acta Psychol (Amst). 2026 May;265:106690. doi: 10.1016/j.actpsy.2026.106690. Epub 2026 Mar 25. PMID- 41886041 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260925 IS - 1590-1262 (Electronic) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Mar 26 TI - A ketogenic diet for the management of binge-eating disorder: a pilot study. LID - 42 [pii] LID - 10.1007/s40519-026-01843-7 [doi] AB - For legal reasons, the publisher has withdrawn this article from public view. For additional information, please contact the publisher. CI - (c) 2026. The Author(s). FAU - Liang, Yixuan AU - Liang Y AD - Department of Neuroscience, Johns Hopkins University, Baltimore, MD, USA. yliang56@jh.edu. FAU - Taylor, Angela AU - Taylor A AD - Department of Clinical Nutrition, Johns Hopkins University, Baltimore, MD, USA. FAU - Qiu, Chuyu AU - Qiu C AD - Department of Molecular and Cellular Biology, Johns Hopkins University, Baltimore, MD, USA. LA - eng PT - Journal Article DEP - 20260326 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - *Diet, Ketogenic/methods MH - Pilot Projects MH - Adult MH - *Binge-Eating Disorder/diet therapy/psychology MH - Female MH - Middle Aged MH - Young Adult MH - Male MH - Adolescent MH - Treatment Outcome MH - Aged MH - Feasibility Studies MH - Body Weight OTO - NOTNLM OT - Binge-Eating Disorder OT - Depression OT - Feasibility OT - Ketogenic Diet OT - Nutritional Intervention EDAT- 2026/03/26 13:32 MHDA- 2026/05/05 00:32 CRDT- 2026/03/26 12:07 PHST- 2025/10/25 00:00 [received] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/05/05 00:32 [medline] PHST- 2026/03/26 13:32 [pubmed] PHST- 2026/03/26 12:07 [entrez] AID - 10.1007/s40519-026-01843-7 [pii] AID - 10.1007/s40519-026-01843-7 [doi] PST - epublish SO - Eat Weight Disord. 2026 Mar 26;31(1):42. doi: 10.1007/s40519-026-01843-7. PMID- 41885771 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1941-2444 (Electronic) IS - 0148-6071 (Print) IS - 0148-6071 (Linking) VI - 50 IP - 4 DP - 2026 May TI - Guidelines for replacement of a balloon gastrostomy tube in infants and pediatric patients: The American Society for Parenteral and Enteral Nutrition. PG - 462-485 LID - 10.1002/jpen.70080 [doi] AB - BACKGROUND: Balloon gastrostomy tube (BGT) placements are increasing due to their ability to facilitate care of medically complex children. Management for routine and nonroutine tube replacement, including verification of proper replacement, lacks standardization, varying widely among different institutions and settings. Currently, no overall standard of care exists for placement verification following BGT replacement, which can occur anywhere. This guideline provides recommendations on topics surrounding best practices, timing, and education confirming newly replaced BGTs. METHODS: An interdisciplinary team developed key questions and performed a systematic search of the PubMed/MEDLINE, EMBASE, CINAHL, and Cochrane Central databases from January 2008 to October 2025. Recommendations were developed for questions concerning timing of routine BGT replacement, weighing the impact of comorbidities and extenuating circumstances, standard and additional methods to confirm BGT replacement position, confirmation of placement when the BGT is traumatically or accidentally dislodged, and how care bundles and clinician education around BGT replacement impact patient outcomes. RESULTS: Three studies were included (one validation and two pre-post studies). Recommendations were made for when additional measures beyond aspiration of gastric contents (e.g., radiographic contrast study) are indicated, use of ultrasound in lieu of a contrast study, what care bundle components improve patient outcomes, and what topics should be covered in clinician education for BGT replacement confirmation. CONCLUSION: This guideline provides placement confirmation guidance for clinicians who perform routine and nonroutine BGT replacements, identifies areas for research, and suggests the use of care bundles to standardize care of this population. This paper was approved by the ASPEN Board of Directors. CI - (c) 2026 The Author(s). Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals LLC on behalf of American Society for Parenteral and Enteral Nutrition. FAU - Lyman, Beth AU - Lyman B AD - Nutrition, Support Nurse Consultant, Smithville, Missouri, USA. FAU - Berman, Loren AU - Berman L AD - Nemours Children's Health, Wilmington, Delaware, USA. FAU - Carr, Kathleen AU - Carr K AD - Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Frank, Cailin AU - Frank C AD - Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis, Tennessee, USA. FAU - Guenter, Peggi AU - Guenter P AUID- ORCID: 0000-0003-2850-246X AD - American Society for Parenteral and Enteral Nutrition, Silver Spring, Maryland, USA. FAU - Kassel, Rachel AU - Kassel R AUID- ORCID: 0000-0001-7953-5953 AD - Department of Pediatrics, Division of Pediatric Gastroenterology, Hepatology, and Nutrition, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama, USA. FAU - Kimble, Janet AU - Kimble J AD - Cedars-Sinai Medical Center, Los Angeles, California, USA. FAU - McGinnis, Carol AU - McGinnis C AUID- ORCID: 0000-0002-2014-8163 AD - Sanford USD Medical Center, Sioux Falls, South Dakota, USA. FAU - Oppedisano, Silvana AU - Oppedisano S AD - Division of Paediatric Medicine, G-Tube Feeding Program, The Hospital for Sick Children, Toronto, Ontario, Canada. FAU - Paton, Elizabeth A AU - Paton EA AD - Department of Acute and Tertiary Care, College of Nursing, Le Bonheur Children's Hospital, University of Tennessee Health Science Center, Memphis, Tennessee, USA. FAU - Rempel, Gina AU - Rempel G AD - Department of Pediatrics and Child Health, Nutrition Support and Complex Care, HSC Winnipeg, Shared Health, Winnipeg, Manitoba, Canada. FAU - Wakeman, Derek S AU - Wakeman DS AUID- ORCID: 0000-0002-2248-7070 AD - University of Rochester Strong Memorial Hospital, Rochester, New York, USA. FAU - Church, David D AU - Church DD AUID- ORCID: 0000-0003-4918-5037 AD - Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA. FAU - Mey, Jacob T AU - Mey JT AUID- ORCID: 0000-0001-6826-7762 AD - Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. FAU - Peterson, Sarah AU - Peterson S AUID- ORCID: 0000-0002-4821-5196 AD - Department of Clinical Nutrition, Rush University Medical Center, Chicago, Illinois, USA. FAU - McKeever, Liam AU - McKeever L AD - Department of Clinical Nutrition, College of Health Sciences, Rush University, Chicago, Illinois, USA. LA - eng PT - Journal Article PT - Practice Guideline DEP - 20260326 PL - United States TA - JPEN J Parenter Enteral Nutr JT - JPEN. Journal of parenteral and enteral nutrition JID - 7804134 SB - IM MH - Humans MH - *Gastrostomy/instrumentation/methods/standards MH - *Enteral Nutrition/standards/methods/instrumentation MH - Child MH - Infant MH - United States MH - *Parenteral Nutrition/standards MH - *Intubation, Gastrointestinal/methods/standards MH - Societies, Medical MH - *Gastric Balloon PMC - PMC13169229 OTO - NOTNLM OT - balloon gastrostomy tube OT - care bundles OT - clinician education OT - pediatrics OT - placement verification OT - practice guideline OT - radiologic contrast study OT - tube dislodgement OT - tube replacement OT - ultrasound COIS- Beth Lyman is a consultant for Avanos, Cardinal Health, and unpaid advisor for Otsuka Pharmaceuticals on issues unrelated to the current project. The remaining authors declare no conflicts of interest. EDAT- 2026/03/26 13:31 MHDA- 2026/05/13 12:32 PMCR- 2026/05/13 CRDT- 2026/03/26 11:03 PHST- 2026/01/28 00:00 [revised] PHST- 2025/12/02 00:00 [received] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/05/13 12:32 [medline] PHST- 2026/03/26 13:31 [pubmed] PHST- 2026/03/26 11:03 [entrez] PHST- 2026/05/13 00:00 [pmc-release] AID - JPEN70080 [pii] AID - 10.1002/jpen.70080 [doi] PST - ppublish SO - JPEN J Parenter Enteral Nutr. 2026 May;50(4):462-485. doi: 10.1002/jpen.70080. Epub 2026 Mar 26. PMID- 41885132 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260824 IS - 1463-1326 (Electronic) IS - 1462-8902 (Linking) VI - 28 IP - 6 DP - 2026 Jun TI - Safety of GLP-1 and Dual GLP-1/GIP Receptor Agonists in Preconception, Pregnancy, and Lactation: A Systematic Review of Maternal, Fetal, and Neonatal Outcomes. PG - 4503-4528 LID - 10.1111/dom.70699 [doi] AB - BACKGROUND AND AIM: Use of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dual GLP-1/glucose-dependent insulinotropic polypeptide (GIP) receptor agonists is increasing among reproductive-aged women for obesity, diabetes, polycystic ovary syndrome (PCOS), and cardiometabolic disease. However, the safety of these agents in pregnancy and lactation remains sparse, while inadvertent first-trimester exposure is becoming more common. The aim of this review is to systematically evaluate maternal, fetal, neonatal, and lactation outcomes following preconception, in-pregnancy, or postpartum exposure to GLP-1 and dual GLP-1/GIP receptor agonists. METHODS: We conducted a systematic review of PubMed/MEDLINE, Web of Science, Scopus, and the Cochrane Library from inception to 23 September 2025. Human studies reporting exposure to GLP-1 or dual GLP-1/GIP receptor agonists during preconception, pregnancy, or lactation were included. Two reviewers independently screened studies, extracted data, and assessed risk of bias using validated tools. Given clinical heterogeneity, findings were synthesised narratively in accordance with PRISMA 2020 guidelines. RESULTS: Thirty-six studies met the inclusion criteria. Across large observational cohorts, periconceptional or early-pregnancy exposure to GLP-1-based therapies was not consistently associated with increased risk of major congenital malformations in adjusted analyses, fetal growth restriction, stillbirth, or neonatal mortality compared with insulin-treated or disease-matched controls. Maternal outcomes, including gestational diabetes, hypertensive disorders of pregnancy, preterm birth, and gestational weight gain, were heterogeneous without a reproducible safety signal. Indeed, in women with PCOS, GLP-1RAs seem promising in various aspects. Lactation data were sparse; one pharmacokinetic study reported no detectable semaglutide transfer into human milk. CONCLUSION: Current evidence suggests that preconceptional or early-pregnancy exposure to GLP-1-based therapies is not consistently associated with increased maternal, fetal, or neonatal risk, although data on continued use throughout gestation remain limited. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Ozbek, Lasin AU - Ozbek L AUID- ORCID: 0000-0002-2828-555X AD - Department of Medicine, Koc University School of Medicine, Istanbul, Turkey. FAU - Shah, Ermeena AU - Shah E AUID- ORCID: 0009-0008-8759-7992 AD - Department of Medicine, Koc University School of Medicine, Istanbul, Turkey. FAU - Al-Shiab, Rama AU - Al-Shiab R AUID- ORCID: 0009-0009-0741-893X AD - Department of Medicine, Koc University School of Medicine, Istanbul, Turkey. FAU - Inal, Azra AU - Inal A AD - Department of Medicine, Koc University School of Medicine, Istanbul, Turkey. FAU - Guldan, Mustafa AU - Guldan M AUID- ORCID: 0000-0002-0480-5370 AD - Department of Medicine, Koc University School of Medicine, Istanbul, Turkey. FAU - Afsar, Baris AU - Afsar B AUID- ORCID: 0000-0002-1369-3657 AD - Department of Medicine, Division of Nephrology, Suleyman Demirel University School of Medicine, Istanbul, Turkey. FAU - Covic, Adrian AU - Covic A AUID- ORCID: 0000-0002-9985-2486 AD - Department of Medicine, Division of Nephrology, Grigore T. Popa University of Medicine and Pharmacy Iasi, Iasi, Romania. FAU - Kanbay, Mehmet AU - Kanbay M AUID- ORCID: 0000-0002-1297-0675 AD - Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260326 PL - England TA - Diabetes Obes Metab JT - Diabetes, obesity & metabolism JID - 100883645 RN - D6H00MV7K8 (gastric inhibitory polypeptide receptor) RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) RN - 0 (Hypoglycemic Agents) RN - 0 (Receptors, Gastrointestinal Hormone) SB - IM MH - Female MH - Humans MH - Infant, Newborn MH - Pregnancy MH - *Glucagon-Like Peptide-1 Receptor Agonists MH - *Hypoglycemic Agents/adverse effects MH - *Lactation/drug effects MH - Pregnancy Outcome/epidemiology MH - *Receptors, Gastrointestinal Hormone/agonists OTO - NOTNLM OT - GLP-1 receptor agonists OT - congenital anomalies OT - drug safety OT - dual GLP-1/GIP receptor agonists OT - lactation OT - maternal outcomes OT - neonatal outcomes OT - preconception counselling OT - pregnancy EDAT- 2026/03/26 13:31 MHDA- 2026/05/06 06:40 CRDT- 2026/03/26 06:43 PHST- 2026/03/04 00:00 [revised] PHST- 2026/01/19 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/05/06 06:40 [medline] PHST- 2026/03/26 13:31 [pubmed] PHST- 2026/03/26 06:43 [entrez] AID - 10.1111/dom.70699 [doi] PST - ppublish SO - Diabetes Obes Metab. 2026 Jun;28(6):4503-4528. doi: 10.1111/dom.70699. Epub 2026 Mar 26. PMID- 41884688 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260326 LR - 20260813 IS - 2325-9671 (Print) IS - 2325-9671 (Electronic) IS - 2325-9671 (Linking) VI - 14 IP - 3 DP - 2026 Mar TI - Mandarin Chinese Translation and Cross-Cultural Adaptation of the Hospital for Special Surgery Pediatric Functional Activity Brief Scale (Chinese HSS Pedi-FABS). PG - 23259671251408800 LID - 10.1177/23259671251408800 [doi] LID - 23259671251408800 AB - BACKGROUND: The Hospital for Special Surgery Pediatric Functional Activity Brief Scale (HSS Pedi-FABS), consisting of 8 simple questions, is a useful tool for quantifying children's physical activity for research and clinical practice. Because of cultural diversity and variation in native languages across regions, translation and cross-cultural adaptation of patient-reported outcome measures is required. PURPOSE: To translate, cross-culturally adapt, and validate a Chinese version of the HSS Pedi-FABS questionnaire. STUDY DESIGN: Cohort study (diagnosis); Level of evidence, 2. METHODS: The HSS Pedi-FABS was translated into Chinese following a standardized 5-step forward-backward protocol, including translation, synthesis, back translation, expert review, and pretesting. Healthy children aged 10 to 18 years completed the Chinese HSS Pedi-FABS along with the Physical Activity Questionnaire for Older Children (PAQ-C) or Physical Activity Questionnaire for Adolescents (PAQ-A) for construct validation. Test-retest reliability was assessed over a 7- to 30-day interval, internal consistency was measured using Cronbach alpha, and construct validity was evaluated using Pearson correlation coefficients. RESULTS: A total of 184 children aged 10 to 18 years participated. The Chinese HSS Pedi-FABS demonstrated excellent internal consistency (Cronbach alpha = .93) and test-retest reliability (ICC = 0.98). Strong correlations were observed with PAQ-C (r = 0.85) in participants aged 10 to 12 and PAQ-A (r = 0.89) in those aged 13 to 18 years, supporting construct validity. CONCLUSION: Our study demonstrated that the Chinese version of the HSS Pedi-FABS is a well-validated and reliable instrument for assessing physical activity among healthy Chinese-speaking children and adolescents. This work will assist future researchers in studying and developing physical activity-related outcome measures for Chinese-speaking children. CI - (c) The Author(s) 2026. FAU - Hong, Chih-Kai AU - Hong CK AUID- ORCID: 0000-0003-3231-1789 AD - Department of Orthopaedic Surgery, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. FAU - Tsai, Ru-Ting AU - Tsai RT AD - Cathay General Hospital, Taipei, Taiwan. FAU - Fabricant, Peter D AU - Fabricant PD AUID- ORCID: 0000-0002-8070-685X AD - Pediatric Orthopaedic Surgery Service, Hospital for Special Surgery, New York, New York, USA. FAU - Wang, Chi-Hsiu AU - Wang CH AD - Department of Nursing, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. FAU - Lee, Su-Ying AU - Lee SY AD - Department of Nursing, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. FAU - Shih, Chien-An AU - Shih CA AD - Department of Orthopaedic Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. FAU - Wang, Jou-Hua AU - Wang JH AUID- ORCID: 0009-0005-0475-2917 AD - Department of Orthopaedic Surgery, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan. AD - Department of Orthopedics, National Cheng Kung University Hospital Dou-Liou Branch, College of Medicine, National Cheng Kung University, Yunlin, Taiwan. LA - eng PT - Journal Article DEP - 20260318 PL - United States TA - Orthop J Sports Med JT - Orthopaedic journal of sports medicine JID - 101620522 PMC - PMC13009762 OTO - NOTNLM OT - HSS Pedi-FABS OT - adolescent OT - cross-cultural adaptation OT - pediatric OT - physical activity COIS- One or more of the authors has declared the following potential conflict of interest or source of funding: This study was funded by National Cheng Kung University Hospital, Tainan, Taiwan (NCKUH-11404061) and National Science and Technology Council, Taiwan (112-2314-B-002-331-MY3). AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto. This study was approved by the institutional review board of National Cheng Kung University Hospital, Tainan, Taiwan (No. A-ER-114-267). EDAT- 2026/03/26 07:09 MHDA- 2026/03/26 07:10 PMCR- 2026/03/18 CRDT- 2026/03/26 05:07 PHST- 2025/10/24 00:00 [received] PHST- 2025/11/11 00:00 [accepted] PHST- 2026/03/26 07:10 [medline] PHST- 2026/03/26 07:09 [pubmed] PHST- 2026/03/26 05:07 [entrez] PHST- 2026/03/18 00:00 [pmc-release] AID - 10.1177_23259671251408800 [pii] AID - 10.1177/23259671251408800 [doi] PST - epublish SO - Orthop J Sports Med. 2026 Mar 18;14(3):23259671251408800. doi: 10.1177/23259671251408800. eCollection 2026 Mar. PMID- 41884030 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260326 LR - 20260813 IS - 2219-2808 (Print) IS - 2219-2808 (Electronic) IS - 2219-2808 (Linking) VI - 15 IP - 1 DP - 2026 Mar 9 TI - Interplay of childhood metabolic dysfunction-associated steatotic liver disease and obesity in the development of youth-onset type 2 diabetes. PG - 111030 LID - 10.5409/wjcp.v15.i1.111030 [doi] LID - 111030 AB - BACKGROUND: The global increase in childhood and adolescent obesity has significantly contributed to the rising prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) - a condition now recognized as a key metabolic complication in youth. MASLD significantly increases the risk of youth-onset type 2 diabetes (T2D), particularly among obese individuals. Its asymptomatic progression presents considerable challenges for timely diagnosis and intervention. AIM: To review epidemiology, pathophysiological mechanisms, and management strategies related to pediatric MASLD, exploring its interaction with obesity and youth-onset T2D. METHODS: A comprehensive literature search was conducted using PubMed, Scopus, and Google Scholar to identify peer-reviewed studies published between 2015 and 2025. Keywords included "pediatric MASLD", "childhood obesity", "youth-onset type 2 diabetes", "hepatic insulin resistance", and "noninvasive biomarkers". Articles were selected based on relevance, methodological quality, and focus on human pediatric populations. RESULTS: MASLD affects approximately 13% of children globally and up to 47% of those with obesity, with the highest prevalence reported in urban areas of the United States, China, and India. In children and adolescents, excess adiposity is the leading contributor to hepatic steatosis and metabolic dysfunction, particularly when body mass exceeds standard growth benchmarks for age and sex. MASLD increases the risk of adolescent T2D by approximately 2.7-fold. Key pathophysiological mechanisms include hepatic insulin resistance, mitochondrial dysfunction, and chronic inflammation, driven by lipotoxic metabolites such as ceramides and pro-inflammatory cytokines. Lifestyle modifications - particularly low free-sugar diets and structured physical activity - have demonstrated moderate efficacy in reducing hepatic fat and improving metabolic outcomes. Pharmacologic interventions, including glucagon-like peptide-1 receptor agonists such as liraglutide and semaglutide, show potential for weight reduction and glycemic control, though their effects on hepatic histology remain under investigation. CONCLUSION: MASLD represents a critical metabolic threat in pediatric populations, strongly influenced by obesity and closely associated with increased risk of youth-onset T2D. Effective management requires early detection, multidisciplinary interventions, and equitable access to care. Future research should prioritize the validation of noninvasive diagnostic tools, development of targeted therapies, and reduction of socioeconomic and ethnic disparities in disease burden and treatment outcomes. CI - (c)Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc. FAU - Parizad, Razieh AU - Parizad R AD - Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz 51656/87386, Iran. FAU - Hatwal, Juniali AU - Hatwal J AD - Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India. FAU - Brar, Ajit Singh AU - Brar AS AD - Department of Internal Medicine, Michigan State University at Hurley Medical Center, Flint, MI 48503, United States. FAU - Alizadeh, Leila AU - Alizadeh L AD - Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz 5166/15731, Iran. FAU - Goyal, Manjeet Kumar AU - Goyal MK AD - Department of Internal Medicine, Cleveland Clinic Akron General Hospital, Akron, OH 110029, United States. FAU - Batta, Akash AU - Batta A AD - Department of Cardiology, Dayanand Medical College and Hospital, Ludhiana 141001, Punjab, India. akashbatta02@gmail.com. FAU - Mohan, Bishav AU - Mohan B AD - Department of Cardiology, Dayanand Medical College and Hospital, Ludhiana 141001, Punjab, India. LA - eng PT - Journal Article DEP - 20260309 PL - United States TA - World J Clin Pediatr JT - World journal of clinical pediatrics JID - 101627548 PMC - PMC13010889 OTO - NOTNLM OT - Childhood obesity OT - Insulin resistance OT - Metabolic dysfunction-associated steatotic liver disease OT - Metabolic syndrome OT - Non-alcoholic fatty liver disease OT - Pediatric OT - Type 2 diabetes mellitus COIS- Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript. EDAT- 2026/03/26 07:09 MHDA- 2026/03/26 07:10 PMCR- 2026/03/09 CRDT- 2026/03/26 05:00 PHST- 2025/06/23 00:00 [received] PHST- 2025/07/24 00:00 [revised] PHST- 2025/10/28 00:00 [accepted] PHST- 2026/03/26 07:10 [medline] PHST- 2026/03/26 07:09 [pubmed] PHST- 2026/03/26 05:00 [entrez] PHST- 2026/03/09 00:00 [pmc-release] AID - 10.5409/wjcp.v15.i1.111030 [doi] PST - epublish SO - World J Clin Pediatr. 2026 Mar 9;15(1):111030. doi: 10.5409/wjcp.v15.i1.111030. eCollection 2026 Mar 9. PMID- 41883903 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260326 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 2 DP - 2026 Feb TI - Modified Peyton's Technique in Pediatric Dental Education to Impart Knowledge and Clinical Skills to Dental Interns for the Preclinical Exercise of Stainless-Steel Crown Preparation: A Quasi-experimental Study. PG - e104041 LID - 10.7759/cureus.104041 [doi] LID - e104041 AB - Background Effective teaching of preclinical skills is crucial for dental interns' transition to clinical practice. Conventional lectures lack the interactivity and reflection required for learning. The Modified Peyton's four-step approach offers a structured, learner-centered method that promotes active engagement and skill retention. Materials and methods A quasi-experimental, double-blinded study was conducted among 70 dental interns randomly and equally assigned to Group A (Modified Peyton's approach) or Group B (conventional technique). Knowledge was assessed using pre- and post-test multiple-choice questions (MCQs). Procedural skills were evaluated eight days later using a validated 25-item checklist by two blinded assessors and through self-assessment. Teaching conditions and materials were standardized, and examiners and statisticians were blinded. Results Both groups showed significant improvement (p < 0.001). Group A (n = 34) demonstrated greater knowledge gains (38.2%-94.1%) compared to Group B (n = 32) (75%-81.3%). Self-assessment gains for selected parameters were significantly higher in Group A (p < 0.001). Strong assessor-self-assessment agreement was observed in Group A, with greater discrepancies in Group B, indicating superior skill replication and self-evaluation consistency. Conclusion The Modified Peyton's approach was more effective than didactic lectures in teaching stainless-steel crown preparation, resulting in improved knowledge, clinical skill performance, and self-assessment accuracy. CI - Copyright (c) 2026, Saraf et al. FAU - Saraf, Tanvi AU - Saraf T AD - Pediatric and Preventive Dentistry, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, IND. FAU - Tafti, Farheen AU - Tafti F AD - Pediatric and Preventive Dentistry, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, IND. FAU - Patil, Amit AU - Patil A AD - Endodontics, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, IND. FAU - Talekar, Shefali AU - Talekar S AD - Conservative Dentistry and Endodontics, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, IND. FAU - Soman, Mrunmayee AU - Soman M AD - Pediatric and Preventive Dentistry, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, IND. FAU - Shaikh, Anam AU - Shaikh A AD - Pediatric and Preventive Dentistry, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai, IND. LA - eng PT - Journal Article DEP - 20260221 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC13010186 OTO - NOTNLM OT - dental education OT - modified peyton's approach OT - preclinical training OT - quasi-experimental study OT - stainless-steel crown COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Ethics Committee for Biomedical and Health Research, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Navi Mumbai issued approval BEC480082024. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/03/26 07:09 MHDA- 2026/03/26 07:10 PMCR- 2026/02/21 CRDT- 2026/03/26 04:59 PHST- 2026/02/17 00:00 [accepted] PHST- 2026/03/26 07:10 [medline] PHST- 2026/03/26 07:09 [pubmed] PHST- 2026/03/26 04:59 [entrez] PHST- 2026/02/21 00:00 [pmc-release] AID - 10.7759/cureus.104041 [doi] PST - epublish SO - Cureus. 2026 Feb 21;18(2):e104041. doi: 10.7759/cureus.104041. eCollection 2026 Feb. PMID- 41883822 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Citizen science for healthier food environments: a realist-informed process evaluation of the big food map app in Flanders, Belgium. PG - 1742139 LID - 10.3389/fpubh.2026.1742139 [doi] LID - 1742139 AB - INTRODUCTION: Food environments, the physical, economic, political, and sociocultural contexts shaping food availability, affordability, marketing, and social norms, strongly influence dietary behaviors and population health. The Big Food Map (De Grote Voedselkaart) was developed as a large scale citizen science initiative to engage citizens across Flanders, Belgium, in documenting and reflecting on their local food environments, aiming to raise awareness and support local action for healthy and sustainable food environments. METHODS: The Big Food Map smartphone application was co-created with citizens, particularly adolescents and adults on lower incomes, as well as with actors, such as local governments, retailers, and short-chain initiatives. Co-creation involved Photovoice workshops with adolescents and adults on lower incomes and Group Model Building sessions with actors to explore how they understand food environments and identify key food environment dimensions and settings. Citizens and actors also tested and refined the app. The app was launched in May 2025 until August 2025 to crowdsource and provide feedback on citizen perceptions and behaviors related to neighborhood food environments. A brief evaluation questionnaire assessed the app's usefulness and potential behavioral impact among citizens, while a more detailed survey explored stakeholder perspectives on the co-creation process and policy relevance. RESULTS: In total 4,707 citizens contributed data across 1,320 neighborhoods (48% of all Flemish neighborhoods) and evaluated 11,313 food outlets. Participants appreciated the opportunity to visualize and discuss their local food environments. Approximately half liked the app's design, 24% reported increased awareness of their food environment, and 56% said they would participate again. Both citizens and stakeholders highlighted challenges around long-term engagement, technical usability, and inclusion of vulnerable groups. The co-creation process strengthened partnerships between research, policy, and practice and underscored the value of tailoring citizen science tools to local contexts and communication channels. DISCUSSION: The Big Food Map demonstrates the feasibility and potential of citizen science to enrich food environment monitoring and stimulate local dialog and action. To sustain engagement and policy relevance, future efforts should strengthen collaboration with local governments and media, diversify participation strategies, and embed citizen science tools into municipal food policy strategies or frameworks. CI - Copyright (c) 2026 Vandevijvere, Benhaiem, Lamberts-Van Assche, Van Kerckhove, D'Hooghe, Marechal, Peijnenborg and Verbeke. FAU - Vandevijvere, Stefanie AU - Vandevijvere S AD - Sciensano, Brussels, Belgium. FAU - Benhaiem, Jonathan AU - Benhaiem J AD - Sciensano, Brussels, Belgium. FAU - Lamberts-Van Assche, Lara AU - Lamberts-Van Assche L AD - Sciensano, Brussels, Belgium. FAU - Van Kerckhove, Jessie AU - Van Kerckhove J AD - Sciensano, Brussels, Belgium. FAU - D'Hooghe, Suzannah AU - D'Hooghe S AD - Sciensano, Brussels, Belgium. FAU - Marechal, Claire AU - Marechal C AD - Arteveldehogeschool, Ghent, Belgium. FAU - Peijnenborg, Myrthe AU - Peijnenborg M AD - Rikolto, Leuven, Belgium. FAU - Verbeke, Katrien AU - Verbeke K AD - Let Us, Destelbergen, Belgium. LA - eng PT - Journal Article DEP - 20260310 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Belgium MH - *Citizen Science MH - Humans MH - *Mobile Applications MH - Adult MH - Adolescent MH - Female MH - Male MH - *Food Supply MH - *Health Promotion/methods MH - Residence Characteristics MH - *Diet, Healthy PMC - PMC13008956 OTO - NOTNLM OT - Flanders OT - citizen science OT - co-creation OT - food environments OT - food policy OT - health promotion COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/26 07:09 MHDA- 2026/03/26 07:10 PMCR- 2026/03/10 CRDT- 2026/03/26 04:59 PHST- 2025/11/08 00:00 [received] PHST- 2026/01/05 00:00 [revised] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/03/26 07:10 [medline] PHST- 2026/03/26 07:09 [pubmed] PHST- 2026/03/26 04:59 [entrez] PHST- 2026/03/10 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1742139 [doi] PST - epublish SO - Front Public Health. 2026 Mar 10;14:1742139. doi: 10.3389/fpubh.2026.1742139. eCollection 2026. PMID- 41883638 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260326 LR - 20260813 IS - 2277-9531 (Print) IS - 2319-6440 (Electronic) IS - 2277-9531 (Linking) VI - 15 DP - 2026 TI - Midwife competency training management model based on Participatory Innovative Collaborative (PILAR) for stunting prevention in West Nias Regency. PG - 93 LID - 10.4103/jehp.jehp_702_25 [doi] LID - 93 AB - BACKGROUND: Stunting is a persistent challenge in Indonesia, particularly in regions like West Nias Regency, where limited access to healthcare and education impacts maternal and child health. Midwives are essential in combating stunting, but there is a lack of effective training models to enhance their competencies in this area. This study aims to analyze the characteristics, assess the feasibility, and determine the effectiveness of the Participatory, Innovative, and Collaborative (PILAR)-based midwife competency training management model for stunting prevention in West Nias Regency. MATERIAL AND METHODS: The research employed the Research and Development (R&D) method, involving midwives from the region. The model was developed through several stages, including needs analysis, model development, field trials, and final evaluation. RESULTS: The research results show that the model is highly feasible, with an average expert feasibility score of 87.48% and an average user trial score of 84.68%. After the trial, the average midwife competency increased from 35.03 to 59.76, with an average competency gain of 24.73. CONCLUSIONS: These findings indicate that the PILAR model can significantly improve midwives' knowledge and skills in stunting prevention. CI - Copyright: (c) 2026 Journal of Education and Health Promotion. FAU - Simatupang, Mei Yati AU - Simatupang MY AD - Department of Lecture of Public Health Study Program, Faculty of Public Health Study Program, STIKes Nauli Husada Sibolga, Sibolga, Sumatera Utara, Indonesia. FAU - Gultom, Syawal AU - Gultom S AD - Department of Education Management, Faculty of Education Management, Universitas Negeri Medan, Kabupaten Deli Serdang, Sumatera Utara, Indonesia. FAU - Rahman, Arif AU - Rahman A AD - Department of Education Management, Faculty of Education Management, Universitas Negeri Medan, Kabupaten Deli Serdang, Sumatera Utara, Indonesia. LA - eng PT - Journal Article DEP - 20260227 PL - India TA - J Educ Health Promot JT - Journal of education and health promotion JID - 101593794 PMC - PMC13012415 OTO - NOTNLM OT - Management OT - PILAR OT - midwife OT - midwife competency OT - training COIS- There are no conflicts of interest. EDAT- 2026/03/26 07:09 MHDA- 2026/03/26 07:10 PMCR- 2026/02/27 CRDT- 2026/03/26 04:57 PHST- 2025/04/15 00:00 [received] PHST- 2025/07/28 00:00 [accepted] PHST- 2026/03/26 07:10 [medline] PHST- 2026/03/26 07:09 [pubmed] PHST- 2026/03/26 04:57 [entrez] PHST- 2026/02/27 00:00 [pmc-release] AID - JEHP-15-93 [pii] AID - 10.4103/jehp.jehp_702_25 [doi] PST - epublish SO - J Educ Health Promot. 2026 Feb 27;15:93. doi: 10.4103/jehp.jehp_702_25. eCollection 2026. PMID- 41883371 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260326 LR - 20260813 IS - 2833-8278 (Electronic) IS - 2833-8278 (Linking) VI - 4 IP - 3 DP - 2026 Mar 20 TI - Antibiotic Exposure and Early Reproductive Outcomes of In Vitro Fertilization (IVF) in a Chinese Couple-Based Preconception Cohort. PG - 379-391 LID - 10.1021/envhealth.5c00182 [doi] AB - Dietary antibiotic exposure is very common, and animal studies have suggested that environmental antibiotic exposure has harmful effects on human reproduction and embryo development. However, there are no population-based cohort studies on the effects of parental antibiotic exposure on early IVF outcomes. A total of 33 antibiotics and 1 metabolite with detection rates over 10% in both female and male partners were included. Couples' early IVF reproductive outcomes included the blastocyst numbers, best-quality embryo numbers, embryo numbers, best-quality embryo rates, two pronuclei (2PN) rates, and blastocyst rates. We applied the adaptive elastic net (AENET) with 10-fold cross-validation to identify antibiotics associated with early IVF outcomes in couples. According to the antibiotics identified by AENET, quantile-based g-computation (QGC) models, group-weighted quantile sum (GWQS) regression, and partitioning around medoids (PAM) algorithms were used to evaluate the joint associations of parental antibiotic mixtures with early IVF reproductive outcomes. The independent associations between antibiotics identified by AENET, antibiotic classes, and early IVF reproductive outcomes in couples were evaluated using the multivariate generalized linear mixed model (GLMM) with random intercepts. In this couple-based prospective cohort study, 739 couples with 947 fresh cycles were included between December 2020 and August 2023. The mean age (SD) was 34.08 (5.48) years for male partners and 33.09 (5.22) years for female partners. In couple-based analyses, sulfaclozine, roxithromycin, sulfamonomethoxine, erythromycin, and penicillin V were positively related to several early IVF reproductive outcomes, while sulfamethoxazole, penicillin G, chlorotetracycline, norfloxacin, florfenicol amine (FFA), sulfadiazine, cyadox, and sulfachloropyridazine were negatively related to early IVF outcomes. Among antibiotic classes, human antibiotics (HAs), beta-lactams, chloramphenicols, and quinoxalines had positive effects on early IVF outcomes, while sulfonamides, preferred as veterinary antibiotics (PVAs), and lincosamides had inverse effects on early IVF outcomes. Similar results were also observed in male partners and female partners. The association between parental antibiotic exposure and IVF outcomes requires further validation in a larger cohort of couples. Additionally, the extrapolation of our results to the general childbearing-aged couples requires caution as infertile couples may be more susceptible to antibiotics. CI - (c) 2025 The Authors. Co-published by Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, and American Chemical Society. FAU - Chen, Yingying AU - Chen Y AD - School of Public Health, Anhui Medical University, Hefei 230032, China. RINGGOLD: 12485 AD - Center for Adverse Drug Reaction Monitoring of Anhui Province, Hefei 230041, China. AD - MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei 230032, China. AD - Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei 230032, China. FAU - Shao, Shanshan AU - Shao S AD - School of Public Health, Anhui Medical University, Hefei 230032, China. RINGGOLD: 12485 AD - MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei 230032, China. AD - Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei 230032, China. AD - Center for Big Data and Population Health of IHM, Anhui Medical University, Hefei, Anhui Province 230032, China. FAU - Wang, Baolin AU - Wang B AD - School of Public Health, Anhui Medical University, Hefei 230032, China. RINGGOLD: 12485 AD - MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei 230032, China. AD - Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei 230032, China. FAU - Gao, Yaya AU - Gao Y AD - School of Public Health, Anhui Medical University, Hefei 230032, China. RINGGOLD: 12485 FAU - Tang, Yanlan AU - Tang Y AD - School of Public Health, Anhui Medical University, Hefei 230032, China. RINGGOLD: 12485 FAU - Sun, Yaning AU - Sun Y AD - School of Public Health, Anhui Medical University, Hefei 230032, China. RINGGOLD: 12485 FAU - Xia, Luobin AU - Xia L AD - School of Public Health, Anhui Medical University, Hefei 230032, China. RINGGOLD: 12485 FAU - Gao, Xin AU - Gao X AD - School of Public Health, Anhui Medical University, Hefei 230032, China. RINGGOLD: 12485 FAU - Wang, Sheng AU - Wang S AD - School of Public Health, Anhui Medical University, Hefei 230032, China. RINGGOLD: 12485 AD - MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei 230032, China. AD - Center for Scientific Research, Anhui Medical University, Hefei 230032, China. FAU - Tang, Ying AU - Tang Y AD - School of Nursing, Anhui Medical University, Hefei 230032, China. FAU - Bao, Shuangshuang AU - Bao S AD - School of Public Health, Anhui Medical University, Hefei 230032, China. RINGGOLD: 12485 AD - MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei 230032, China. AD - Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei 230032, China. FAU - Geng, Menglong AU - Geng M AD - School of Public Health, Anhui Medical University, Hefei 230032, China. RINGGOLD: 12485 AD - MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei 230032, China. AD - Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei 230032, China. FAU - Zhu, Peng AU - Zhu P AD - School of Public Health, Anhui Medical University, Hefei 230032, China. RINGGOLD: 12485 AD - MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei 230032, China. AD - Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei 230032, China. FAU - Tao, Fangbiao AU - Tao F AUID- ORCID: 0000-0002-3039-6961 AD - School of Public Health, Anhui Medical University, Hefei 230032, China. RINGGOLD: 12485 AD - MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei 230032, China. AD - Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei 230032, China. FAU - Pan, Guixia AU - Pan G AUID- ORCID: 0000-0002-1278-8486 AD - The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China. AD - School of Public Health, Anhui Medical University, Hefei 230032, China. RINGGOLD: 12485 AD - MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei 230032, China. AD - Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, Anhui Medical University, Hefei 230032, China. LA - eng PT - Journal Article DEP - 20251015 PL - United States TA - Environ Health (Wash) JT - Environment & health (Washington, D.C.) JID - 9918646069906676 PMC - PMC13010295 OTO - NOTNLM OT - antibiotics OT - cohort study OT - couple OT - fertility OT - in vitro fertilization EDAT- 2026/03/26 07:09 MHDA- 2026/03/26 07:10 PMCR- 2025/10/15 CRDT- 2026/03/26 04:55 PHST- 2025/06/06 00:00 [received] PHST- 2025/09/15 00:00 [revised] PHST- 2025/09/25 00:00 [accepted] PHST- 2026/03/26 07:10 [medline] PHST- 2026/03/26 07:09 [pubmed] PHST- 2026/03/26 04:55 [entrez] PHST- 2025/10/15 00:00 [pmc-release] AID - 10.1021/envhealth.5c00182 [doi] PST - epublish SO - Environ Health (Wash). 2025 Oct 15;4(3):379-391. doi: 10.1021/envhealth.5c00182. eCollection 2026 Mar 20. PMID- 41883328 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Mar 26 TI - The role of household food insecurity in malnutrition among Indonesian children under 5 years of age: a systematic review and meta-analysis (2015-2025). PG - e86 LID - 10.1017/S1368980026102365 [doi] LID - e86 AB - OBJECTIVE: To synthesise and quantify the association between household food insecurity (HFI) and various forms of malnutrition that include stunting, wasting, underweight, overnutrition and anaemia among Indonesian children under 5 years of age. DESIGN: A systematic review and meta-analysis was conducted in accordance with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines. The study included literature search, screening, data extraction, quality assessment using Joanna Briggs Institute (JBI) tools and meta-analysis using Review Manager 5.4. SETTING: Studies conducted in Indonesia, covering urban, rural and mixed settings across multiple provinces. PARTICIPANTS: Children under 5 years of age residing in Indonesia, from households assessed for food insecurity using validated tools. RESULTS: A total of thirty-two studies met the inclusion criteria, of which twenty-six were eligible for meta-analysis. HFI was significantly associated with higher odds of stunting (case-control: OR = 4.66; 95 % CI: 3.39, 6.40; P < 0.001; cross-sectional: OR = 4.61; 95 % CI: 4.17, 5.11; P < 0.001), wasting (OR = 1.92; 95 % CI: 1.60, 2.32; P < 0.001), underweight (OR = 5.26; 95 % CI: 2.12, 13.04; P < 0.001) and overnutrition (OR = 1.66; 95 % CI: 1.49, 1.85; P < 0.001). Children in food-secure households had significantly lower odds of anaemia (OR = 0.41; 95 % CI: 0.30, 0.58; P < 0.001). CONCLUSIONS: HFI is strongly associated with multiple forms of malnutrition among Indonesian children under 5 years of age. These findings highlight the urgent need for integrated, nutrition-sensitive strategies that address food security to improve child health and reduce malnutrition in Indonesia. FAU - Sutrisno, Rahayu AU - Sutrisno R AUID- ORCID: 0000-0002-8867-0222 AD - Master of Nutrition Science Study Program, Faculty of Health Sciences, Universitas Brawijaya, Indonesia. FAU - Fatmawati, Irka Dwi AU - Fatmawati ID AD - Master of Nutrition Science Study Program, Faculty of Health Sciences, Universitas Brawijaya, Indonesia. FAU - Laksono, Agung Dwi AU - Laksono AD AD - Research Center of Public Health and Nutrition, National Research and Innovation Agency Republic of Indonesia, Indonesia. FAU - Rahmawati, Widya AU - Rahmawati W AUID- ORCID: 0000-0003-4139-5064 AD - Nutrition Department, Faculty of Health Sciences, https://ror.org/01wk3d929Universitas Brawijaya, Indonesia. FAU - Wirawan, Nia Novita AU - Wirawan NN AD - Nutrition Department, Faculty of Health Sciences, https://ror.org/01wk3d929Universitas Brawijaya, Indonesia. FAU - Handayani, Dian AU - Handayani D AUID- ORCID: 0000-0001-9018-0233 AD - Nutrition Department, Faculty of Health Sciences, https://ror.org/01wk3d929Universitas Brawijaya, Indonesia. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260326 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Indonesia/epidemiology MH - *Food Insecurity MH - Child, Preschool MH - *Child Nutrition Disorders/epidemiology MH - *Family Characteristics MH - Infant MH - *Malnutrition/epidemiology MH - Thinness/epidemiology MH - Growth Disorders/epidemiology MH - Wasting Syndrome/epidemiology MH - Anemia/epidemiology MH - Female MH - Male PMC - PMC13112310 OTO - NOTNLM OT - Child malnutrition OT - Household food insecurity OT - Indonesia OT - Meta-analysis OT - Systematic review COIS- There are no conflicts of interest. EDAT- 2026/03/26 07:09 MHDA- 2026/04/15 06:29 PMCR- 2026/03/26 CRDT- 2026/03/26 04:53 PHST- 2026/04/15 06:29 [medline] PHST- 2026/03/26 07:09 [pubmed] PHST- 2026/03/26 04:53 [entrez] PHST- 2026/03/26 00:00 [pmc-release] AID - S1368980026102365 [pii] AID - 10.1017/S1368980026102365 [doi] PST - epublish SO - Public Health Nutr. 2026 Mar 26;29(1):e86. doi: 10.1017/S1368980026102365. PMID- 41882922 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260827 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 1 DP - 2026 Jan TI - Maternal and Child Diet Quality Trajectories and Their Determinants. PG - e70171 LID - 10.1111/mcn.70171 [doi] LID - e70171 AB - This study examined the trajectories of maternal and child diet quality in the first 5 years postpartum and their determinants. Data of 330 mother-child pairs from the Melbourne Infant Feeding, Activity and Nutrition Trial Programme were used. Maternal and child dietary data were collected using validated food frequency questionnaires, with maternal data collected when children were aged 4, 18, 42 and 60 months and child data at ages 18, 42 and 60 months. Maternal and child diet quality were calculated using the 2013 Dietary Guideline Index and the Dietary Guideline Index for Children and Adolescents, respectively. Group-based multi-trajectory modelling was conducted to examine multi-trajectory groups following distinct joint trajectories of maternal and child diet quality. Determinants of multi-trajectory groups were evaluated using logistic regression. Three distinct multi-trajectory groups of low (10.9%), moderate (57.6%) and high (31.5%) maternal and child diet quality were identified; high diet quality represented better adherence to dietary guidelines. Higher maternal prepregnancy BMI was associated with a higher relative risk of following the low (RRR 1.11; 95% CI: 1.02, 1.21) versus the high maternal and child diet quality multi-trajectory group. Breastfeeding for >/= 6 months was associated with a lower relative risk (RRR 0.37; 95% CI: 0.15, 0.91) of following the low versus the high maternal and child diet quality multi-trajectory group. The longitudinal association between maternal and child diet quality suggests that interventions to improve maternal diet quality will likely benefit child diet quality. Interventions should target women with a high prepregnancy BMI and promote breastfeeding. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Sexton-Dhamu, Meaghan J AU - Sexton-Dhamu MJ AUID- ORCID: 0000-0003-2752-8350 AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. FAU - Livingstone, Katherine M AU - Livingstone KM AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. FAU - Szymlek-Gay, Ewa A AU - Szymlek-Gay EA AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. FAU - Campbell, Karen J AU - Campbell KJ AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. FAU - Zheng, Miaobing AU - Zheng M AUID- ORCID: 0000-0002-4151-3502 AD - Institute for Physical Activity and Nutrition, School of Exercise and Nutrition Sciences, Deakin University, Geelong, Victoria, Australia. AD - School of Health Sciences, Faculty of Health & Medicine, University of New South Wales, Sydney, New South Wales, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Female MH - *Diet MH - Infant MH - Breast Feeding MH - *Maternal Nutritional Physiological Phenomena MH - Child, Preschool MH - Adult MH - Mothers MH - Male MH - Nutrition Policy MH - Body Mass Index MH - *Child Nutritional Physiological Phenomena MH - Infant Nutritional Physiological Phenomena PMC - PMC13344142 OTO - NOTNLM OT - child OT - diet quality OT - maternal OT - trajectories COIS- The authors declare no conflicts of interest. EDAT- 2026/03/26 07:09 MHDA- 2026/03/26 07:10 PMCR- 2026/03/25 CRDT- 2026/03/26 01:03 PHST- 2026/01/29 00:00 [revised] PHST- 2025/02/25 00:00 [received] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/03/26 07:10 [medline] PHST- 2026/03/26 07:09 [pubmed] PHST- 2026/03/26 01:03 [entrez] PHST- 2026/03/25 00:00 [pmc-release] AID - MCN70171 [pii] AID - 10.1111/mcn.70171 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jan;22(1):e70171. doi: 10.1111/mcn.70171. PMID- 41882615 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Mar 26 TI - Development and validation of a tool to assess mothers' knowledge, perception, and practice of child growth monitoring. LID - 10.1186/s12884-026-08972-y [doi] LID - 486 AB - BACKGROUND: Child growth monitoring (CGM) is essential for the early detection and prevention of malnutrition and growth abnormalities. Despite its importance, there is a lack of validated instruments to assess mothers' knowledge, perceptions, and practices related to CGM. This study aimed to develop and validate a comprehensive questionnaire to assess these domains among mothers of children under five years of age. METHODS: The study was conducted in two stages. First, a theory-driven questionnaire was developed based on an extensive literature review, global and national guidelines, and expert consultation. Second, the questionnaire's psychometric properties were evaluated using data from a cross-sectional survey of 436 mothers. An expert panel assessed content validity, internal consistency was examined using Cronbach's alpha, and construct validity was evaluated using confirmatory factor analysis (CFA). RESULTS: The final questionnaire comprised 67 items across three domains: knowledge (27 items), perception (14 items), and practice (11 items). The instrument demonstrated good overall internal consistency (Cronbach's alpha = 0.82), with strong reliability across main domains (alpha = 0.81-0.92). CFA supported the hypothesized three-domain structure, with good model fit indices for the full measurement model (CMIN/DF = 1.62; CFI = 0.93; TLI = 0.93; RMSEA = 0.038). CONCLUSION: This study presents a valid and reliable questionnaire for assessing mothers' knowledge, perceptions, and practices regarding CGM. The tool can support research, inform maternal education strategies, and guide public health interventions to improve early childhood growth outcomes. FAU - Masuadi, Emad AU - Masuadi E AUID- ORCID: 0000-0002-7360-7693 AD - Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, 15551, United Arab Emirates. emasuadi@uaeu.ac.ae. AD - Epidemiology and Biostatistical Consulting Unit, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, 15551, United Arab Emirates. emasuadi@uaeu.ac.ae. FAU - Cheikh Ismail, Leila AU - Cheikh Ismail L AUID- ORCID: 0000-0003-3048-7481 AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates. AD - Nuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, OX1 2JD, UK. FAU - Saleh, Sheima T AU - Saleh ST AUID- ORCID: 0000-0003-2871-1341 AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates. FAU - Hashim, Mona AU - Hashim M AUID- ORCID: 0000-0002-3494-4718 AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates. FAU - Hasan, Haydar AU - Hasan H AUID- ORCID: 0000-0001-5580-1911 AD - Department of Clinical Nutrition and Dietetics, College of Health Sciences, University of Sharjah, Sharjah, 27272, United Arab Emirates. FAU - Mohamad, Maysm N AU - Mohamad MN AUID- ORCID: 0000-0002-6396-6625 AD - Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, 15551, United Arab Emirates. FAU - Stojanovska, Lily AU - Stojanovska L AUID- ORCID: 0000-0001-7186-4461 AD - Institute for Health and Sport, Victoria University, Melbourne, VIC, 3011, Australia. FAU - Elhadi, Yasir Ahmed Mohammed AU - Elhadi YAM AUID- ORCID: 0000-0003-3649-0374 AD - Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, 15551, United Arab Emirates. FAU - Al Dhaheri, Ayesha AU - Al Dhaheri A AUID- ORCID: 0000-0002-7634-3531 AD - Department of Nutrition and Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, 15551, United Arab Emirates. LA - eng PT - Journal Article PT - Validation Study DEP - 20260326 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - *Health Knowledge, Attitudes, Practice MH - Female MH - *Mothers/psychology MH - Surveys and Questionnaires/standards MH - Cross-Sectional Studies MH - *Child Development MH - Psychometrics MH - Reproducibility of Results MH - Adult MH - Child, Preschool MH - Infant MH - Factor Analysis, Statistical MH - Young Adult PMC - PMC13141268 OTO - NOTNLM OT - Child Growth Monitoring OT - Early Childhood Development OT - Maternal Health Education OT - Maternal Perceptions OT - Parental Health Literacy COIS- Declarations. Ethics approval and consent to participate: This study adhered to the guidelines outlined in the Declaration of Helsinki. Ethical approval was granted by the Research Human Ethics Committee at the University of Sharjah (Ref: REC-23-02-09-01), the UAE Ministry of Health and Prevention (Ref: MOHAP/REC/2022/21-2023-PG-M), and the University Hospital of Sharjah (Ref: UHS-HERC-132-21052023). Additionally, internal approval was secured from the management of each participating hospital. Informed written consent was obtained from all participants before the study commenced. The data collection process involved systematically recording participant responses online through a digital platform. These responses were then exported into an Excel spreadsheet for comprehensive analysis. The collected data were securely stored on a password-protected research computer to ensure confidentiality and maintain data integrity throughout the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/26 07:09 MHDA- 2026/06/28 00:38 PMCR- 2026/03/26 CRDT- 2026/03/26 00:48 PHST- 2024/09/30 00:00 [received] PHST- 2026/03/18 00:00 [accepted] PHST- 2026/06/28 00:38 [medline] PHST- 2026/03/26 07:09 [pubmed] PHST- 2026/03/26 00:48 [entrez] PHST- 2026/03/26 00:00 [pmc-release] AID - 10.1186/s12884-026-08972-y [pii] AID - 8972 [pii] AID - 10.1186/s12884-026-08972-y [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Mar 26;26(1):486. doi: 10.1186/s12884-026-08972-y. PMID- 41882547 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2731-4553 (Electronic) IS - 2731-4553 (Linking) VI - 27 IP - 1 DP - 2026 Mar 25 TI - Nutritional assessment and lifestyle counseling for pregnant women in primary health care units in Mexico: implementation evaluation. LID - 10.1186/s12875-026-03257-x [doi] LID - 174 AB - BACKGROUND: Maternal malnutrition, expressed as both undernutrition and excessive gestational weight gain, remains a major public health challenge in Mexico. Primary health care units are the main platform for the provision of evidence-based nutritional interventions, including nutritional status assessment and counseling on healthy eating and physical activity. However, there is limited knowledge about their systematic implementation in routine prenatal care. This study aimed to evaluate the implementation of these interventions in primary health care units in Morelos, Mexico, focusing on key implementation outcomes. METHODS: A mixed-methods sequential design was applied. Quantitative data were collected through structured and validated questionnaires with health personnel (n = 59) to assess acceptability, adoption, and feasibility; review of physical records of prenatal consultations (n = 1,067) to estimate coverage; and non-participant observation of consultations (n = 368) to measure fidelity. Implementation outcomes were assessed using validated instruments and compliance checklists. Descriptive statistics and multiple linear regression analyses were performed. Qualitative data were obtained through in-depth interviews with health personnel and pregnant women (n = 24) from a subsample of 12 units between April and May 2025, analyzed thematically to explore perceptions, facilitators, and barriers. RESULTS: Health personnel expressed high acceptability and willingness to adopt nutritional interventions, although only 27% had received specific training in nutrition care. Coverage of weight measurement was nearly universal, but hemoglobin testing (24.6%) and nutritional status assessment (8.2%) had very low performance, particularly in rural units. Fidelity varied across interventions: nutritional assessment achieved the highest compliance (47.8%), while counseling on healthy eating (19.1%) and physical activity (8.6%) were rarely implemented. Structural barriers included limited consultation time, lack of educational materials, and excessive workload. Pregnant women valued counseling but reported economic and cultural challenges to adopting recommendations. CONCLUSIONS: Although health personnel show strong acceptance of nutritional interventions, their implementation in primary care is hindered by systemic barriers. Low coverage and fidelity, especially in rural contexts, represent missed opportunities to improve maternal and child health. Greater training, resources, and integration of structured counseling into prenatal care are needed to strengthen equity and effectiveness of services. FAU - Pacheco-Miranda, Selene AU - Pacheco-Miranda S AD - Nutrition and Health Research Center, National Institute of Public Health, Cuernavaca, Mexico. AD - Vitamin Angels Alliance, Mexico City, Mexico. FAU - Cruz-Casarrubias, Carlos AU - Cruz-Casarrubias C AD - Nutrition and Health Research Center, National Institute of Public Health, Cuernavaca, Mexico. FAU - Paola-Arequipa Toapanta, Renata AU - Paola-Arequipa Toapanta R AD - School of Public Health, National Institute of Public Health of Mexico, Cuernavaca, Mexico. FAU - Perez-Escamilla, Rafael AU - Perez-Escamilla R AD - Department of Social and Behavioral Sciences, Yale School of Public Health, New Haven, CT, USA. FAU - Reyes-Morales, Hortensia AU - Reyes-Morales H AD - Health Systems Research Center, National Institute of Public Health, Cuernavaca, Mexico. FAU - Denova-Gutierrez, Edgar AU - Denova-Gutierrez E AD - Department of Nutrition, National Institute of Medical Sciences and Nutrition Salvador Zubiran, Mexico City, Mexico. FAU - Hernandez-Barrera, Lucia AU - Hernandez-Barrera L AD - Nutrition and Health Research Center, National Institute of Public Health, Cuernavaca, Mexico. FAU - Rios-Espinosa, Enrique AU - Rios-Espinosa E AD - Vitamin Angels Alliance, Mexico City, Mexico. FAU - Bonvecchio-Arenas, Anabelle AU - Bonvecchio-Arenas A AD - School of Public Health, National Institute of Public Health of Mexico, Cuernavaca, Mexico. bonvecchio@insp.mx. LA - eng PT - Journal Article DEP - 20260325 PL - England TA - BMC Prim Care JT - BMC primary care JID - 9918300889006676 SB - IM MH - Humans MH - Female MH - Mexico MH - Pregnancy MH - *Primary Health Care MH - *Counseling/methods MH - Adult MH - *Prenatal Care/methods MH - *Nutrition Assessment MH - Exercise MH - *Life Style MH - Young Adult MH - Diet, Healthy MH - *Pregnancy Complications/prevention & control MH - Malnutrition/prevention & control PMC - PMC13137730 OTO - NOTNLM OT - Implementation science OT - Maternal nutrition OT - Prenatal care OT - Primary health care COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethics, Research, and Biosafety Committees of the National Institute of Public Health of Mexico (November 2023, Project CI 14179), and authorized by the State Coordination of IMSS-BIENESTAR Health Services in Morelos (July 2024, Reference No. JSAS-095/2024). This research was conducted in accordance with the principles outlined in the Declaration of Helsinki. All participants provided written informed consent prior to enrollment and the initiation of data collection activities. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/26 07:09 MHDA- 2026/06/28 00:38 PMCR- 2026/03/25 CRDT- 2026/03/26 00:44 PHST- 2025/10/21 00:00 [received] PHST- 2026/03/03 00:00 [accepted] PHST- 2026/06/28 00:38 [medline] PHST- 2026/03/26 07:09 [pubmed] PHST- 2026/03/26 00:44 [entrez] PHST- 2026/03/25 00:00 [pmc-release] AID - 10.1186/s12875-026-03257-x [pii] AID - 3257 [pii] AID - 10.1186/s12875-026-03257-x [doi] PST - epublish SO - BMC Prim Care. 2026 Mar 25;27(1):174. doi: 10.1186/s12875-026-03257-x. PMID- 41881109 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260718 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 222 DP - 2026 Jul 1 TI - School children's food literacy and dietary behaviors according to maternal food literacy in Korea. PG - 108543 LID - S0195-6663(26)00105-4 [pii] LID - 10.1016/j.appet.2026.108543 [doi] AB - BACKGROUND AND OBJECTIVE: A caregiver's food literacy (FL) is a key factor in their children's FL and healthy dietary behaviors. However, the research on the relationship between FL and its outcomes is limited, especially among the Korean population. Thus, this cross-sectional study was conducted to examine the relationship between maternal FL and primary school children's FL and dietary behaviors in Korea. METHODS: A total of 800 participants, including mothers and their children simultaneously, were enrolled in an online survey conducted in June 2021. This included 400 mothers who were the primary caregivers for their children in the household and their 400 children, who were in the 4th to 6th grades of elementary school. The subjects responded to the FL questionnaire as well as questions about their general characteristics, dietary habits. The food literacy questionnaire, which was validated, comprised 25 questions including five factors (production, selection, preparation and cooking, intake, and disposal) for mothers and 19 questions including five factors (production, distribution, selection, preparation and cooking, and intake) for children. RESULTS: There was a positive association between the mother's FL scores and the child's FL scores (r = 0.4586, p < 0.0001). The participants were categorized into quartile groups according to FL scores, maternal FL was significantly associated with child's skipping breakfast [OR (95% CI) = 0.29 (0.16-0.53)], child's skipping lunch [OR (95% CI) = 0.32 (0.16-0.66)], and child's eating-out [OR (95% CI) = 0.32 (0.15-0.68)]. CONCLUSIONS: This study found that maternal FL may positively affect children's FL, as well as their dietary habits. These findings suggest that improving maternal FL may have the potential to promote a healthier diet for their children, although additional research is needed. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Kim, Eun-Kyung AU - Kim EK AD - National Institute of Crop and Food Science, Rural Development Administration, Wanju, South Korea. FAU - Park, Young Hee AU - Park YH AD - National Institute of Crop and Food Science, Rural Development Administration, Wanju, South Korea. FAU - Kwon, Yong-Seok AU - Kwon YS AD - National Institute of Crop and Food Science, Rural Development Administration, Wanju, South Korea. FAU - Kim, Sena AU - Kim S AD - National Institute of Crop and Food Science, Rural Development Administration, Wanju, South Korea. FAU - Lee, Jin-Young AU - Lee JY AD - National Institute of Crop and Food Science, Rural Development Administration, Wanju, South Korea. Electronic address: cherry78@korea.kr. FAU - Shin, Min-Jeong AU - Shin MJ AD - Interdisciplinary Program in Precision Public Health, Department of Public Health Sciences, Graduate School of Korea University, Seoul, South Korea; School of Biosystems and Biomedical Sciences, College of Health Science, Korea University, Seoul, South Korea. LA - eng PT - Journal Article DEP - 20260323 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Child MH - Republic of Korea MH - *Mothers/psychology/statistics & numerical data MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires MH - Male MH - *Health Literacy/statistics & numerical data MH - Adult MH - Diet MH - Diet, Healthy/psychology OTO - NOTNLM OT - Dietary behaviors OT - Eating-out OT - Elementary school children OT - Food literacy OT - Skipping meal COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/26 01:03 MHDA- 2026/05/08 00:32 CRDT- 2026/03/25 20:11 PHST- 2025/02/24 00:00 [received] PHST- 2025/11/27 00:00 [revised] PHST- 2026/03/16 00:00 [accepted] PHST- 2026/05/08 00:32 [medline] PHST- 2026/03/26 01:03 [pubmed] PHST- 2026/03/25 20:11 [entrez] AID - S0195-6663(26)00105-4 [pii] AID - 10.1016/j.appet.2026.108543 [doi] PST - ppublish SO - Appetite. 2026 Jul 1;222:108543. doi: 10.1016/j.appet.2026.108543. Epub 2026 Mar 23. PMID- 41880604 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260826 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Mar 25 TI - Increasing Physical Activity in Educational Settings Using Mixed Reality Technology: Iterative Formative Study. PG - e83556 LID - 10.2196/83556 [doi] LID - e83556 AB - BACKGROUND: As physical education classes are lost to budget cuts and recess is canceled to meet standardized testing goals, the modern school day has become dominated by sedentary digital activities. To reverse this trend, current interventions have focused on reducing screen time. However, instead of fighting this digital invasion, this study examined the use of technology, specifically mixed reality, to turn screen time from sedentary into active time, promoting physical activity in a classroom setting. OBJECTIVE: The primary aim of this study was to iteratively develop and test a mixed reality prototype that promotes physical activity (eg, jumping, squatting, and punching) during a digital classroom activity. The primary outcomes were the percentage of active time during the activity, a breakdown of the intensity of that active time, and an evaluation of the prototype's usability. METHODS: Between November 2023 and April 2025, a multidisciplinary research team developed a prototype and evaluated it during 2 rounds of pilot-testing. Participants were aged 10 to 15 years and attended local middle schools. Physical activity was assessed using a medical-grade, hip-worn accelerometer (ActiGraph wGT3X-BT). Acceptability was assessed using a validated questionnaire (the System Usability Scale) that has a maximum score of 100. To collect feedback for prototype improvements, semistructured interviews were conducted after each round of pilot-testing. RESULTS: In the first round of pilot-testing, students (n=22) were active for 46.0% (6.9, SD 2.7 minutes) of the headset session, which lasted 15 (SD 0) minutes. After improving the prototype using feedback from the first round, students in the second round (n=10) were active for 5.8 (SD 3.1) minutes (62.4%) of the web-based assignment, which lasted 9.3 (SD 2.41) minutes, while still reporting "good" acceptability scores (mean 73.8, SD 17.2). There were no significant differences in acceptability ratings between the 2 pilot-testing rounds (P=.16), nor were there differences between boys and girls in round 1 (P=.79) or round 2 (P=.61). CONCLUSIONS: The results of this iterative study indicate that mixed reality can be used to elicit physical activity in a classroom setting, at least for short assignments. However, further research is needed to determine longer-term use and effectiveness. CI - (c) Katherine E Spring, Calvin W Feldt, Matthew Parker Posey, Phillip Nauta, Senlin Chen, David C Shepherd, Amanda E Staiano. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Spring, Katherine E AU - Spring KE AUID- ORCID: 0000-0002-5606-5191 AD - Pennington Biomedical Research Center, 6400 Perkins Rd., Baton Rouge, LA, 70808, United States, 1 2257632729. FAU - Feldt, Calvin W AU - Feldt CW AUID- ORCID: 0009-0009-1185-5833 AD - Division of Computer Science and Engineering, Louisiana State University, Baton Rouge, LA, United States. FAU - Posey, Matthew Parker AU - Posey MP AUID- ORCID: 0009-0004-2290-5860 AD - Division of Computer Science and Engineering, Louisiana State University, Baton Rouge, LA, United States. FAU - Nauta, Phillip AU - Nauta P AUID- ORCID: 0000-0002-9361-1470 AD - Pennington Biomedical Research Center, 6400 Perkins Rd., Baton Rouge, LA, 70808, United States, 1 2257632729. FAU - Chen, Senlin AU - Chen S AUID- ORCID: 0000-0003-0945-4271 AD - School of Kinesiology, Louisiana State University, Baton Rouge, LA, United States. FAU - Shepherd, David C AU - Shepherd DC AUID- ORCID: 0000-0003-2017-7842 AD - Division of Computer Science and Engineering, Louisiana State University, Baton Rouge, LA, United States. FAU - Staiano, Amanda E AU - Staiano AE AUID- ORCID: 0000-0001-7846-046X AD - Pennington Biomedical Research Center, 6400 Perkins Rd., Baton Rouge, LA, 70808, United States, 1 2257632729. LA - eng GR - T32 DK064584/DK/NIDDK NIH HHS/United States GR - U54 GM104940/GM/NIGMS NIH HHS/United States GR - P30DK072476/NIH National Institute of Diabetes and Digestive and Kidney Diseases/ PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20260325 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - *Exercise/psychology MH - Child MH - Adolescent MH - Female MH - Male MH - *Physical Education and Training/methods MH - Schools/organization & administration MH - Surveys and Questionnaires MH - Accelerometry/instrumentation/methods PMC - PMC13016437 OTO - NOTNLM OT - active learning technologies OT - digital learning tools OT - middle school OT - mixed reality OT - school-based physical activity COIS- Conflicts of Interest: None declared. EDAT- 2026/03/25 19:36 MHDA- 2026/03/25 19:37 PMCR- 2026/03/25 CRDT- 2026/03/25 15:43 PHST- 2025/09/04 00:00 [received] PHST- 2026/02/23 00:00 [accepted] PHST- 2026/03/25 19:37 [medline] PHST- 2026/03/25 19:36 [pubmed] PHST- 2026/03/25 15:43 [entrez] PHST- 2026/03/25 00:00 [pmc-release] AID - v10i1e83556 [pii] AID - 83556 [pii] AID - 10.2196/83556 [doi] PST - epublish SO - JMIR Form Res. 2026 Mar 25;10:e83556. doi: 10.2196/83556. PMID- 41880458 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260713 IS - 1518-8787 (Electronic) IS - 0034-8910 (Linking) VI - 60 DP - 2026 TI - Profile of food and beverage street vendors around private schools in Brazil. PG - e14 LID - S0034-89102026000100613 [pii] LID - 10.11606/s1518-8787.2026060007205 [doi] AB - OBJECTIVE: To describe the socioeconomic profile and activity of street vendors, as well as the profile of food sales, according to industrial processing, in the vicinity of private schools in Brazilian state capitals. METHODS: Cross-sectional study with street vendors in the immediate vicinity of a national probability sample of Brazilian private schools. Elementary and/or high schools participating in the Food Marketing in Brazilian Schools Study were included. A previously validated questionnaire was applied to characterize workers, infrastructure and food availability. Food was classified according to the NOVA system. Comparisons between macro-regions (North, Northeast, Central-West, Southeast, and South) and sizes of point of sale (smallest: 1-3 items; intermediate: 4-13 items; largest: >/= 14 items) were evaluated using the Kruskal-Wallis test. RESULTS: The informal food and beverage trade in the immediate vicinity of 2,180 private schools was mapped, totaling 699 street vendors. There was a predominance of men (57.8%), black people (68.8%), those with completed secondary education (35.8%), and those who worked informally (91.4%), in carts and stalls, due to a lack of opportunity in the formal market (52.5%). The median number of ultra-processed items was about twice that of in natura, minimally processed, or processed foods and preparations based on them (2.17; 95%CI 1.90-2.45). Larger outlets concentrated more ultra-processed foods in all regions, except in the Northeast, where this predominance already occurred in intermediate-sized outlets (3.32; 95%CI 2.88-3.75). The lowest ratio of ultra-processed foods was observed in the South (0.21; 95%CI 0.05-0.37) and the highest in the Northeast (3.32; 95%CI 2.88-3.75). CONCLUSION: Street vending around Brazilian private schools reflects structural inequalities and expands commercially in the supply of ultra-processed foods to children and adolescents. We recommend its inclusion as an inseparable component in the evaluation of the school food environment, to support policies that reconcile income generation and the promotion of healthy eating. FAU - Clark, Sabrina Gomes Ferreira AU - Clark SGF AUID- ORCID: 0000-0002-9037-4553 AD - Universidade Federal de Pernambuco. Centro de Ciencias da Saude. Servico-Escola de Nutricao Emilia Aureliano. Recife, PE, Brasil. FAU - Mendes, Larissa Loures AU - Mendes LL AUID- ORCID: 0000-0003-0776-6845 AD - Universidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Nutricao. Belo Horizonte, MG, Brasil. FAU - Oliveira, Juliana Souza AU - Oliveira JS AUID- ORCID: 0000-0003-1449-8930 AD - Universidade Federal de Pernambuco. Centro Academico de Vitoria. Departamento de Nutricao. Vitoria de Santo Antao, PE, Brasil. FAU - Borges, Luiza Delazari AU - Borges LD AUID- ORCID: 0000-0002-9399-255X AD - Universidade Federal de Minas Gerais. Escola de Enfermagem. Departamento de Nutricao. Belo Horizonte, MG, Brasil. FAU - Tavares, Leticia Ferreira AU - Tavares LF AUID- ORCID: 0000-0001-5205-2994 AD - Universidade Federal do Rio de Janeiro. Instituto de Nutricao Josue de Castro. Rio de Janeiro, RJ, Brasil. FAU - Castro Junior, Paulo Cesar Pereira de AU - Castro Junior PCP AUID- ORCID: 0000-0002-6629-9610 AD - Universidade Federal do Rio de Janeiro. Instituto de Nutricao Josue de Castro. Rio de Janeiro, RJ, Brasil. FAU - Cardoso, Leticia de Oliveira AU - Cardoso LO AUID- ORCID: 0000-0003-1312-1808 AD - Fundacao Oswaldo Cruz. Escola Nacional de Saude Publica Sergio Arouca. Rio de Janeiro, RJ, Brasil. FAU - Canuto, Raquel AU - Canuto R AUID- ORCID: 0000-0002-4042-1913 AD - Universidade Federal do Rio Grande do Sul. Faculdade de Medicina. Departamento de Nutricao. Porto Alegre, RS, Brasil. LA - eng LA - por PT - Journal Article DEP - 20260320 PL - Brazil TA - Rev Saude Publica JT - Revista de saude publica JID - 0135043 SB - IM MH - Humans MH - Brazil MH - Cross-Sectional Studies MH - *Schools/statistics & numerical data MH - Socioeconomic Factors MH - Male MH - Female MH - Private Sector/statistics & numerical data MH - Street Food MH - *Commerce/statistics & numerical data MH - *Beverages/supply & distribution MH - Surveys and Questionnaires EDAT- 2026/03/25 19:36 MHDA- 2026/03/25 19:37 CRDT- 2026/03/25 13:53 PHST- 2025/07/18 00:00 [received] PHST- 2026/01/11 00:00 [accepted] PHST- 2026/03/25 19:37 [medline] PHST- 2026/03/25 19:36 [pubmed] PHST- 2026/03/25 13:53 [entrez] AID - S0034-89102026000100613 [pii] AID - 10.11606/s1518-8787.2026060007205 [doi] PST - epublish SO - Rev Saude Publica. 2026 Mar 20;60:e14. doi: 10.11606/s1518-8787.2026060007205. eCollection 2026. PMID- 41880371 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 3 DP - 2026 TI - From habit to high risk: The influence of multidimensional lifestyle changes on internet addiction risk among junior high school students and its predictive utility. PG - e0345506 LID - 10.1371/journal.pone.0345506 [doi] LID - e0345506 AB - OBJECTIVE: To investigate how changes in the daily lifestyles of junior high school students influence the risk of Internet addiction, and to develop precise, lifestyle-based intervention strategies for preventing and reducing such addiction. METHODS: In April 2024, a follow-up survey was conducted on a cohort first assessed in September 2023. The relationship between various dynamic changes in daily lifestyle-encompassing four dimensions: exercise, smart device ownership, diet, sleep-wake patterns and the risk of Internet addiction was analyzed. The predictive performance of these factors was evaluated using Receiver Operating Characteristic (ROC) curves. RESULTS: Of the 10,535 participants enrolled at baseline (T1), 9,750 were successfully followed up at T2, yielding a retention rate of 92.55% (9,750/10,535). Among these, 7,853 provided complete and valid questionnaire data, corresponding to a T2 effective data rate of 80.54% (7,853/9,750). The detected rate of Internet addiction risk increased from 10.62% at T1 to 13.35% at T2. Multivariate analysis identified the following behavioral changes as significant risk factors for Internet addiction: going to bed after 10:00 pm or having delayed sleep onset timing (OR = 2.859, 95% CI: 2.319-3.525); developing late-night eating habit (OR = 1.932, 95% CI: 1.494-2.499); becoming a smart device owner (OR = 1.773, 95% CI: 1.307-2.405); being a non-habitual napper (OR = 1.699, 95% CI: 1.408-2.049); decreased pursuit of dietary balance (OR = 1.654, 95% CI: 1.300-2.104); decreased active exercise (OR = 1.575, 95% CI: 1.222-2.031); and decrease in exercise duration per session (OR = 1.436, 95% CI: 1.117-1.846). A predictive model incorporating six key variables (excluding change in habitual late-night eating) demonstrated acceptable performance, with an area under the ROC curve (AUC) of 0.721 (95% CI: 0.701-0.741). CONCLUSION: This six-month longitudinal study systematically reveals that adverse changes across four lifestyle dimensions significantly increase the risk of Internet addiction among junior high school students. These findings provide an empirical basis for developing targeted interventions to prevent and reduce this risk. CI - Copyright: (c) 2026 Yu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Yu, Xinwei AU - Yu X AUID- ORCID: 0009-0007-9434-5825 AD - Health Science Center, Yangtze University, Jingzhou City, Hubei Province, China. AD - Mental Health Center of Yangtze University, Jingzhou City, Hubei Province, China. AD - Jingzhou Mental Health Center, Jingzhou City, Hubei Province, China. FAU - Zhang, Li AU - Zhang L AD - Health Science Center, Yangtze University, Jingzhou City, Hubei Province, China. AD - Mental Health Center of Yangtze University, Jingzhou City, Hubei Province, China. AD - Jingzhou Mental Health Center, Jingzhou City, Hubei Province, China. FAU - Su, Xuejian AU - Su X AD - Health Science Center, Yangtze University, Jingzhou City, Hubei Province, China. AD - Mental Health Center of Yangtze University, Jingzhou City, Hubei Province, China. AD - Jingzhou Mental Health Center, Jingzhou City, Hubei Province, China. FAU - Yu, Ye AU - Yu Y AD - Health Science Center, Yangtze University, Jingzhou City, Hubei Province, China. AD - Mental Health Center of Yangtze University, Jingzhou City, Hubei Province, China. AD - Jingzhou Mental Health Center, Jingzhou City, Hubei Province, China. AD - Jingzhou Rongjun Special Care Hospital, Jingzhou City, Hubei Province, China. FAU - Liu, Bo AU - Liu B AD - Health Science Center, Yangtze University, Jingzhou City, Hubei Province, China. AD - Mental Health Center of Yangtze University, Jingzhou City, Hubei Province, China. AD - Jingzhou Mental Health Center, Jingzhou City, Hubei Province, China. AD - Jingzhou Rongjun Special Care Hospital, Jingzhou City, Hubei Province, China. FAU - Zhou, Lifang AU - Zhou L AD - Health Science Center, Yangtze University, Jingzhou City, Hubei Province, China. AD - Mental Health Center of Yangtze University, Jingzhou City, Hubei Province, China. AD - Jingzhou Mental Health Center, Jingzhou City, Hubei Province, China. AD - Jingzhou Rongjun Special Care Hospital, Jingzhou City, Hubei Province, China. FAU - Deng, Xiaopeng AU - Deng X AUID- ORCID: 0009-0002-1709-4085 AD - Health Science Center, Yangtze University, Jingzhou City, Hubei Province, China. AD - Mental Health Center of Yangtze University, Jingzhou City, Hubei Province, China. AD - Jingzhou Mental Health Center, Jingzhou City, Hubei Province, China. AD - Jingzhou Rongjun Special Care Hospital, Jingzhou City, Hubei Province, China. LA - eng PT - Journal Article DEP - 20260325 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adolescent MH - *Internet Addiction Disorder/epidemiology/prevention & control/psychology MH - *Life Style MH - Female MH - *Students/psychology MH - Risk Factors MH - Male MH - Surveys and Questionnaires MH - Internet MH - *Habits MH - ROC Curve MH - Schools MH - Exercise MH - Sleep PMC - PMC13016319 COIS- The authors have declared that no competing interests exist. EDAT- 2026/03/25 19:36 MHDA- 2026/03/25 19:37 PMCR- 2026/03/25 CRDT- 2026/03/25 13:43 PHST- 2025/07/17 00:00 [received] PHST- 2026/03/05 00:00 [accepted] PHST- 2026/03/25 19:37 [medline] PHST- 2026/03/25 19:36 [pubmed] PHST- 2026/03/25 13:43 [entrez] PHST- 2026/03/25 00:00 [pmc-release] AID - PONE-D-25-37269 [pii] AID - 10.1371/journal.pone.0345506 [doi] PST - epublish SO - PLoS One. 2026 Mar 25;21(3):e0345506. doi: 10.1371/journal.pone.0345506. eCollection 2026. PMID- 41878823 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260729 IS - 1360-0567 (Electronic) IS - 0963-8237 (Linking) VI - 35 IP - 4 DP - 2026 Aug TI - Key patient characteristics for the acknowledgement of patient heterogeneity in economic evaluations in severe mental illness: a Delphi consensus exercise. PG - 444-454 LID - 10.1080/09638237.2026.2645543 [doi] AB - BACKGROUND: Patient heterogeneity is defined as variation across people, explainable by their characteristics. Heterogeneity in the population with severe mental illness (SMI) is highly relevant. Economic evaluations commonly use population averages, which do not account for patient heterogeneity. AIMS: To identify patient characteristics that should be considered for inclusion in economic evaluations in SMI. METHODS: SMI researchers working in the UK were recruited via email. Recruitment took a purposive and snowball sampling approach. The first and second surveys were completed individually online with a consensus threshold set at >/=75%. The final stage to finalise consensus comprised a ranking task and an online meeting to prioritise the list of patient characteristics. RESULTS: The consensus exercise identified 28 characteristics to account for patient heterogeneity. A prioritised list of ten key characteristics was also produced and included age, socioeconomic status, ethnicity, symptom types and severity, diagnosis, gender identity and/or sex registered at birth, baseline health and/or quality of life, adverse childhood experiences, support network and comorbidities. CONCLUSIONS: This list helps researchers identify, a priori, key patient characteristics. Studies are needed to validate the findings of the consensus exercise with data collection and analysis. We acknowledge that feasibility constraints may affect research. FAU - Shields, Gemma E AU - Shields GE AD - Manchester Centre for Health Economics, Division of Population Health, Health Services Research, and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. FAU - Farragher, Tracey AU - Farragher T AD - Centre for Biostatistics, Manchester Academic Health Science Centre, Division of Population Health, Health Services Research, and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. FAU - Davies, Linda M AU - Davies LM AD - Manchester Centre for Health Economics, Division of Population Health, Health Services Research, and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. FAU - Verma, Arpana AU - Verma A AD - The Epidemiology and Public Health Group (EPHG), Division of Population Health, Health Services Research, and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. FAU - Kirkham, Jamie J AU - Kirkham JJ AD - Centre for Biostatistics, Manchester Academic Health Science Centre, Division of Population Health, Health Services Research, and Primary Care, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. FAU - Makara, Dagmar AU - Makara D AD - Greater Manchester Mental Health NHS Foundation Trust, Prestwich, UK. FAU - Clarkson, Paul AU - Clarkson P AD - Social Care and Society, Division of Nursing, Midwifery and Social Work, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK. LA - eng PT - Journal Article DEP - 20260325 PL - England TA - J Ment Health JT - Journal of mental health (Abingdon, England) JID - 9212352 SB - IM MH - Humans MH - *Mental Disorders/economics MH - Delphi Technique MH - Female MH - *Cost-Benefit Analysis MH - Consensus MH - Male MH - Adult MH - United Kingdom MH - Cost-Effectiveness Analysis OTO - NOTNLM OT - Consensus exercise OT - cost-effectiveness analysis OT - economic evaluation OT - patient heterogeneity OT - severe mental illness EDAT- 2026/03/25 07:09 MHDA- 2026/07/30 00:38 CRDT- 2026/03/25 05:03 PHST- 2026/07/30 00:38 [medline] PHST- 2026/03/25 07:09 [pubmed] PHST- 2026/03/25 05:03 [entrez] AID - 10.1080/09638237.2026.2645543 [doi] PST - ppublish SO - J Ment Health. 2026 Aug;35(4):444-454. doi: 10.1080/09638237.2026.2645543. Epub 2026 Mar 25. PMID- 41878794 OWN - NLM STAT- MEDLINE DCOM- 20260702 LR - 20260920 IS - 1098-108X (Electronic) IS - 0276-3478 (Print) IS - 0276-3478 (Linking) VI - 59 IP - 7 DP - 2026 Jul TI - Eating Disorder Screening in Adults With Williams Syndrome: A Preliminary Report. PG - 1543-1551 LID - 10.1002/eat.70070 [doi] AB - OBJECTIVE: Eating disorder (ED) symptoms have been studied in adults with other rare genetic conditions but not in Williams syndrome (WS). This study examined the prevalence of ED symptoms in adults with WS and associated clinical and demographic factors. We hypothesized that a proportion would screen positive for an ED, primarily with avoidant/restrictive food intake disorder (ARFID) or binge-eating presentations. METHOD: Adults with WS completed modified versions of the Eating Disorder Assessment for DSM-5 and the Pica, ARFID, and Rumination Disorder Questionnaire, administered as semi-structured interviews by trained research staff. Participants also completed a medical history questionnaire. We used descriptive and between-group analyses to examine clinical and demographic characteristics of ED-positive and ED-negative groups. RESULTS: Of the 86 participants, more than one quarter (n = 24, 28%; 95% CI [20%, 38%]) screened positive for an ED. Adults who screened positive for an ED most commonly had binge-type EDs (n = 15, 63%; 95% CI [43%, 79%]) and ARFID-type EDs (n = 7, 29%; 95% CI [15%, 49%]). Of those who screened positive, 96% reported they had never been previously diagnosed with an ED. DISCUSSION: Our study provides initial evidence of a high frequency of positive ED screens in adults with WS, most commonly ARFID-type and binge-type EDs. Our findings also suggest that, while prevalent in WS, EDs typically go undetected, and that it may be difficult to identify at-risk individuals. There is a need to validate ED screeners for adults with WS to enhance detection and access to care. CI - (c) 2026 Wiley Periodicals LLC. FAU - Dunford, Ashley AU - Dunford A AUID- ORCID: 0000-0003-4460-6437 AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA. AD - Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA. FAU - Renzi, Danielle AU - Renzi D AUID- ORCID: 0009-0001-8189-8531 AD - Genetics & Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Bitar, Thomas AU - Bitar T AUID- ORCID: 0009-0002-8762-2453 AD - Neuroendocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Gallagher, Aidan AU - Gallagher A AUID- ORCID: 0009-0003-6119-7636 AD - Genetics & Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Thomas, Jennifer J AU - Thomas JJ AUID- ORCID: 0000-0003-2601-581X AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, Massachusetts, USA. AD - Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA. FAU - Thom, Robyn P AU - Thom RP AUID- ORCID: 0000-0002-8026-6970 AD - Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA. AD - Lurie Center for Autism, Massachusetts General Hospital, Boston, Massachusetts, USA. FAU - Pober, Barbara R AU - Pober BR AUID- ORCID: 0000-0003-4210-7634 AD - Genetics & Metabolism, Department of Pediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA. AD - Department of Pediatrics (Emeritus), Harvard Medical School, Boston, Massachusetts, USA. LA - eng GR - K24 MH135189/MH/NIMH NIH HHS/United States GR - K24MH135189/MH/NIMH NIH HHS/United States GR - K24MH135189/MH/NIMH NIH HHS/United States PT - Journal Article DEP - 20260325 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - *Williams Syndrome/complications/psychology/epidemiology MH - Adult MH - Female MH - Male MH - *Feeding and Eating Disorders/diagnosis/epidemiology/complications MH - Young Adult MH - Surveys and Questionnaires MH - Middle Aged MH - Prevalence MH - Avoidant Restrictive Food Intake Disorder MH - Adolescent PMC - PMC13020642 MID - NIHMS2149798 OTO - NOTNLM OT - ARFID OT - BED OT - Williams syndrome OT - avoidant/restrictive food intake disorder OT - binge-eating OT - feeding and eating disorder OT - intellectual disability COIS- Conflicts of Interest: Dr. Thomas receives royalties from Cambridge University Press, Oxford University Press, and Routledge for her books on eating disorders. She also receives consulting fees from Equip Health. Dr. Thom receives royalties from Oxford University Press and Springer Publishing. The other authors declare no conflicts of interest. EDAT- 2026/03/25 07:09 MHDA- 2026/07/02 12:34 PMCR- 2026/03/27 CRDT- 2026/03/25 04:53 PHST- 2026/02/12 00:00 [revised] PHST- 2025/11/12 00:00 [received] PHST- 2026/02/16 00:00 [accepted] PHST- 2026/07/02 12:34 [medline] PHST- 2026/03/25 07:09 [pubmed] PHST- 2026/03/25 04:53 [entrez] PHST- 2026/03/27 00:00 [pmc-release] AID - 10.1002/eat.70070 [doi] PST - ppublish SO - Int J Eat Disord. 2026 Jul;59(7):1543-1551. doi: 10.1002/eat.70070. Epub 2026 Mar 25. PMID- 41878459 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260325 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - The use of an augmented reality app to support an exercise intervention for children and young people with cancer: perspectives of users and exercise and healthcare professionals in the FORTEe trial. PG - 1743212 LID - 10.3389/fped.2026.1743212 [doi] LID - 1743212 AB - BACKGROUND: Mobile health (mHealth) technologies are increasingly used in paediatric oncology to promote physical activity, with growing evidence supporting their feasibility and effectiveness. Augmented reality (AR) is emerging as a promising addition, offering interactive features that may enhance participation in exercise for young people. As mHealth tools evolve, understanding user experiences and implementation challenges is essential to inform wider adoption in healthcare. The FORTEe clinical trial evaluates an individualised exercise programme designed for children, adolescents and young adults with cancer (CAYA). This sub-study explores the perspectives of CAYA and exercise and healthcare professionals involved in delivering the exercise intervention (exercise professionals) on the use of a novel AR application (app), designed to facilitate home-based exercise as part of the broader intervention. Key app features include personalised exercise programmes, AR demonstrations using a child-like avatar, and an integrated exercise diary. METHODS: CAYA (9-21 years), and exercise professionals from the FORTEe trial's technology sub-study (six centres) were eligible. To explore experiences and perceptions of the AR app, half-structured interviews were conducted with CAYA and an anonymous online survey administered to exercise professionals. Interview data and open-ended text from survey was analysed using inductive qualitative content analysis. Survey data was analysed using descriptive statistics. RESULTS: A total of 46 CAYA (mean age 13.6 +/- 2.7 years, 39% female) provided feedback on the AR app via interviews, and 31 exercise professionals completed the survey. CAYA and exercise professionals reported generally positive experiences, finding the AR demonstrations novel and engaging. The personalised workouts were valued by both groups. However, both groups reported some technical difficulties that impacted reliability, and that some features, such as the exercise diary, lacked usability. Exercise professionals emphasised the app should complement rather than replace face-to-face sessions. To enhance the app further, both groups suggested incorporating gamification and avatar customisation. CONCLUSION: This study emphasises the potential of AR technology to increase engagement in exercise among CAYA and highlights ways to optimise the technology. While AR shows promise in paediatric oncology care, it should complement in-person exercise interventions. Future development should prioritise user-friendly design, personalised approaches, and equal access for young patients. CI - (c) 2026 Marriott, Solera-Sanchez, Windsor, Straun, Neu, Dreismickenbecker, Lanfranconi, Villa, Wiskemann, Bauer, Gotte, Beller, Spreafico, Zardo, Wright, Faber and Watson. FAU - Marriott, Hayley AU - Marriott H AD - School of Sport, Nutrition and Allied Health Professions, Faculty of Health Science, and Technology, Oxford Brookes University, Oxford, United Kingdom. FAU - Solera-Sanchez, Alba AU - Solera-Sanchez A AD - School of Sport, Nutrition and Allied Health Professions, Faculty of Health Science, and Technology, Oxford Brookes University, Oxford, United Kingdom. FAU - Windsor, Stanley AU - Windsor S AD - School of Sport, Nutrition and Allied Health Professions, Faculty of Health Science, and Technology, Oxford Brookes University, Oxford, United Kingdom. FAU - Straun, Kim AU - Straun K AD - School for Policy Studies, University of Bristol, Bristol, United Kingdom. FAU - Neu, Marie A AU - Neu MA AD - University Medical Center of the Johannes Gutenberg-University Mainz, Childhood Cancer Center Mainz, Mainz, Germany. FAU - Dreismickenbecker, Elias AU - Dreismickenbecker E AD - University Medical Center of the Johannes Gutenberg-University Mainz, Childhood Cancer Center Mainz, Mainz, Germany. FAU - Lanfranconi, Francesca AU - Lanfranconi F AD - Fondazione Monza e Brianza per Il Bambino e La Sua Mamma, Monza, Italy. FAU - Villa, Emanuele AU - Villa E AD - Fondazione Monza e Brianza per Il Bambino e La Sua Mamma, Monza, Italy. FAU - Wiskemann, Joachim AU - Wiskemann J AD - Exercise Oncology Research Group, Department of Medical Oncology, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and the Heidelberg University Hospital, Heidelberg, Germany. FAU - Bauer, Nikolai AU - Bauer N AD - Exercise Oncology Research Group, Department of Medical Oncology, Heidelberg University Hospital, Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany; National Center for Tumor Diseases (NCT), NCT Heidelberg, a partnership between DKFZ and the Heidelberg University Hospital, Heidelberg, Germany. FAU - Gotte, Miriam AU - Gotte M AD - University Hospital Essen, West German Cancer Center, Essen, Germany. FAU - Beller, Ronja AU - Beller R AD - Clinics for Paediatrics III, Department of Paediatric Haematology/Oncology, West German Cancer Centre, University Hospital Essen, Essen, Germany. FAU - Spreafico, Filippo AU - Spreafico F AD - Oncology Unit, IRCCS Istituto Giannina Gaslini, Genoa, Italy. FAU - Zardo, William AU - Zardo W AD - Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy. FAU - Wright, Peter AU - Wright P AD - School of Sport, Nutrition and Allied Health Professions, Faculty of Health Science, and Technology, Oxford Brookes University, Oxford, United Kingdom. FAU - Faber, Joerg AU - Faber J AD - University Medical Center of the Johannes Gutenberg-University Mainz, Childhood Cancer Center Mainz, Mainz, Germany. FAU - Watson, Eila AU - Watson E AD - Oxford Institute of Applied Health Research, Faculty of Health Science, and Technology, Oxford Brookes University, Oxford, United Kingdom. LA - eng PT - Journal Article DEP - 20260309 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13006567 OTO - NOTNLM OT - augmented reality OT - childhood cancer OT - exercise OT - exercise oncology OT - smartphone app COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/25 07:09 MHDA- 2026/03/25 07:10 PMCR- 2026/03/09 CRDT- 2026/03/25 04:31 PHST- 2025/11/10 00:00 [received] PHST- 2026/02/12 00:00 [revised] PHST- 2026/02/16 00:00 [accepted] PHST- 2026/03/25 07:10 [medline] PHST- 2026/03/25 07:09 [pubmed] PHST- 2026/03/25 04:31 [entrez] PHST- 2026/03/09 00:00 [pmc-release] AID - 10.3389/fped.2026.1743212 [doi] PST - epublish SO - Front Pediatr. 2026 Mar 9;14:1743212. doi: 10.3389/fped.2026.1743212. eCollection 2026. PMID- 41878391 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260325 LR - 20260813 IS - 2772-6967 (Electronic) IS - 2772-6967 (Linking) VI - 5 DP - 2025 Jun TI - 'Making Moves': Protocol for a hybrid effectiveness-implementation pre-post trial of a co-designed online physical activity program for childhood cancer survivors. PG - 100099 LID - 10.1016/j.jsampl.2025.100099 [doi] LID - 100099 AB - BACKGROUND: Childhood cancer survivors are at increased risk of developing chronic health conditions, including cardiovascular disease. Cardiovascular disease risk is further exacerbated by low physical activity levels and high levels of sedentary behaviour. Yet many survivors do not meet the physical activity guidelines, and those living in regional and remote areas have limited access to exercise interventions and cancer care programs. Therefore, it is critical that physical activity programs are accessible for childhood cancer survivors, no matter where they live. This protocol describes the development and planned evaluation of 'Making Moves', a co-designed online physical activity program for childhood cancer survivors aged 8-21 years. METHODS AND ANALYSIS: This type I hybrid effectiveness-implementation pre-post trial will simultaneously (i) test the potential effectiveness of Making Moves on survivors' physical activity self-efficacy, and (ii) explore barriers and facilitators to implementation from multiple levels (individual, provider, organisational, and community) to inform future adaptations and implementation strategies. Making Moves includes an 8-week online program offering eight age-appropriate health behaviour educational modules with guided home-based physical activity videos, and up to five tailored telehealth sessions with an Accredited Exercise Physiologist. Assessment of the primary outcome (physical activity self-efficacy, i.e., perceived ability to engage in physical activity) and secondary outcomes (physical activity levels, aerobic fitness, muscular strength, symptoms of depression, readiness to exercise, perceived enjoyment of exercise, health-related quality of life) will occur at baseline (week 0), post-intervention (week 9), and follow-up (6 months). To assess the factors affecting the program's implementation, we will conduct a process evaluation guided by the Consolidated Framework for Implementation Research 2.0 to interview survivors and parents, and future potential implementors. To judge the potential implementation success of Making Moves, we will collect implementation data (feasibility, acceptability, costs) for our process evaluation throughout the trial. ETHICS AND DISSEMINATION: Ethical approval was obtained from the Sydney Children's Hospital Network Human Research Ethics Committee (2023/ETH01614). We will publish our findings in peer-reviewed journals, present findings at relevant medical and scientific conferences, and disseminate research updates via newsletters to stakeholders and community networks. TRIAL REGISTRATION NUMBER: ANZCTR12623000188639. Registered 22 Feb 2023. CI - (c) 2025 The Author(s). FAU - Ha, Lauren AU - Ha L AD - Behavioural Sciences Unit, Discipline of Paediatrics & Child Health, School of Clinical Medicine, Randwick Clinical Campus, UNSW Medicine & Health, UNSW SYDNEY, Australia. AD - Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia. FAU - Wakefield, Claire E AU - Wakefield CE AD - Behavioural Sciences Unit, Discipline of Paediatrics & Child Health, School of Clinical Medicine, Randwick Clinical Campus, UNSW Medicine & Health, UNSW SYDNEY, Australia. AD - Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia. FAU - Jacovou, Jacqueline AU - Jacovou J AD - Behavioural Sciences Unit, Discipline of Paediatrics & Child Health, School of Clinical Medicine, Randwick Clinical Campus, UNSW Medicine & Health, UNSW SYDNEY, Australia. AD - Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia. FAU - Johnston, Karen AU - Johnston K AD - Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia. FAU - Drew, Donna AU - Drew D AD - Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia. FAU - Donoghoe, Mark W AU - Donoghoe MW AD - Clinical Research Unit, UNSW Medicine & Health, UNSW, Sydney, Australia. FAU - Mizrahi, David AU - Mizrahi D AD - The Daffodil Centre, The University of Sydney, a Joint Venture with Cancer Council NSW, Australia. FAU - Lourenco, Richard De Abreu AU - Lourenco RA AD - Centre for Health Economics Research and Evaluation, UTS, Sydney, Australia. FAU - Cohn, Richard J AU - Cohn RJ AD - Behavioural Sciences Unit, Discipline of Paediatrics & Child Health, School of Clinical Medicine, Randwick Clinical Campus, UNSW Medicine & Health, UNSW SYDNEY, Australia. AD - Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia. FAU - Taylor, Natalie AU - Taylor N AD - School of Population Health, UNSW Medicine & Health, UNSW, Sydney, Australia. FAU - Signorelli, Christina AU - Signorelli C AD - Behavioural Sciences Unit, Discipline of Paediatrics & Child Health, School of Clinical Medicine, Randwick Clinical Campus, UNSW Medicine & Health, UNSW SYDNEY, Australia. AD - Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW, Australia. CN - Youth Advisory Board LA - eng PT - Journal Article DEP - 20250412 PL - England TA - JSAMS Plus JT - JSAMS plus JID - 9918505286106676 PMC - PMC13008450 OTO - NOTNLM OT - Childhood cancer OT - Digital health OT - Exercise OT - Implementation OT - Physical activity OT - Survivorship COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. FIR - Roughley, Kiarn IR - Roughley K FIR - Joyner, Callum IR - Joyner C FIR - Wright, Aj IR - Wright A EDAT- 2026/03/25 07:09 MHDA- 2026/03/25 07:10 PMCR- 2025/04/12 CRDT- 2026/03/25 04:30 PHST- 2025/03/18 00:00 [received] PHST- 2025/03/27 00:00 [revised] PHST- 2025/04/01 00:00 [accepted] PHST- 2026/03/25 07:10 [medline] PHST- 2026/03/25 07:09 [pubmed] PHST- 2026/03/25 04:30 [entrez] PHST- 2025/04/12 00:00 [pmc-release] AID - S2772-6967(25)00013-4 [pii] AID - 100099 [pii] AID - 10.1016/j.jsampl.2025.100099 [doi] PST - epublish SO - JSAMS Plus. 2025 Apr 12;5:100099. doi: 10.1016/j.jsampl.2025.100099. eCollection 2025 Jun. PMID- 41878288 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260325 LR - 20260813 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Associations between perceived physical literacy and physical fitness tests among the adult population. PG - 1783118 LID - 10.3389/fspor.2026.1783118 [doi] LID - 1783118 AB - INTRODUCTION: The multidimensional concept of physical literacy (PL) is increasingly recognized as a holistic framework supporting lifelong physical activity. Although research is growing, empirical evidence remains limited and focused mainly on children and adolescents. In adults the relationship between subjectively measured (perceived) PL and objectively measured physical fitness tests is still unclear. The aim of this study was therefore to examine associations between overall and domain-specific perceived PL and multiple components of physical fitness in an adult population. METHODS: An exploratory cross-sectional study was conducted with 180 adults (60% women; mean age 40.71 +/- 15.79 years), recruited during community-based physical activity education events in rural Austria. Perceived PL was assessed using the Perceived Physical Literacy Questionnaire (PPLQ), which captures six domains: motivation, confidence, physical competence, knowledge, understanding, and physical activity behavior. Physical fitness was evaluated through a series of field-based tests assessing cardiorespiratory fitness, muscular strength, flexibility of the upper and lower extremities, balance, and reaction time. Spearman correlation coefficients were calculated for the total sample and subsamples stratified by gender and age (<45/ >/= 45 years). In line with the exploratory nature of the study, interpretation focused exclusively on effect sizes following Cohen's conventions. RESULTS: Across all fitness parameters, the strongest correlations emerged for overall PL and the physical competence domain, followed by the physical activity behavior and confidence domains. In turn, the weakest correlations were observed for the motivation, knowledge, and understanding domains. Overall, correlations ranged predominantly from small-to-moderate, with notable variation across gender- and age-specific subgroups; in men and younger adults, correlations were generally stronger. CONCLUSION: This study provides new insights into the relationship between overall/domain-specific perceived PL and physical fitness tests in the adult population, particularly regarding less commonly explored fitness parameters such as upper extremity flexibility, reaction time, and balance. Given the exploratory nature of the study, future research with larger, more diverse, and probability-based samples is needed to strengthen both the internal and external validity of these findings. CI - (c) 2026 Holler, Dohr, Tuttner, Amort, van Poppel and Jaunig. FAU - Holler, Peter AU - Holler P AD - Department of Human Movement Science, Sport and Health, University of Graz, Graz, Austria. AD - FH JOANNEUM-University of Applied Sciences, Institute of Health and Tourism Management, Bad Gleichenberg, Austria. AD - Sport Science Laboratory, FH JOANNEUM-University of Applied Sciences, Bad Gleichenberg, Austria. FAU - Dohr, Sandra AU - Dohr S AD - Geriatric Health Centres of the City of Graz, Albert Schweitzer Institute for Geriatrics and Gerontology, Graz, Austria. AD - Department of Management, University of Klagenfurt, Klagenfurt, Austria. FAU - Tuttner, Silvia AU - Tuttner S AD - FH JOANNEUM-University of Applied Sciences, Institute of Health and Tourism Management, Bad Gleichenberg, Austria. FAU - Amort, Frank Michael AU - Amort FM AD - FH JOANNEUM-University of Applied Sciences, Institute of Health and Tourism Management, Bad Gleichenberg, Austria. FAU - van Poppel, Mireille AU - van Poppel M AD - Department of Human Movement Science, Sport and Health, University of Graz, Graz, Austria. FAU - Jaunig, Johannes AU - Jaunig J AD - Department of Human Movement Science, Sport and Health, University of Graz, Graz, Austria. LA - eng PT - Journal Article DEP - 20260309 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC13006595 OTO - NOTNLM OT - adults OT - cross-sectional study OT - fitness tests OT - perceived physical literacy OT - physical activity OT - physical competence OT - physical fitness OT - physical literacy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer AM declared a past co-authorship with the author JJ to the handling editor. EDAT- 2026/03/25 07:09 MHDA- 2026/03/25 07:10 PMCR- 2026/03/09 CRDT- 2026/03/25 04:29 PHST- 2026/01/07 00:00 [received] PHST- 2026/02/06 00:00 [revised] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/03/25 07:10 [medline] PHST- 2026/03/25 07:09 [pubmed] PHST- 2026/03/25 04:29 [entrez] PHST- 2026/03/09 00:00 [pmc-release] AID - 10.3389/fspor.2026.1783118 [doi] PST - epublish SO - Front Sports Act Living. 2026 Mar 9;8:1783118. doi: 10.3389/fspor.2026.1783118. eCollection 2026. PMID- 41878060 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260325 LR - 20260920 IS - 2473-4039 (Electronic) IS - 2473-4039 (Linking) VI - 10 IP - 4 DP - 2026 Apr TI - Rethinking race-based interpretation in pediatric densitometry: a scoping review. PG - ziag028 LID - 10.1093/jbmrpl/ziag028 [doi] LID - ziag028 AB - As pediatric populations in the United States (US) become increasingly diverse, current practices for interpreting bone density using DXA in children warrant reevaluation. The International Society for Clinical Densitometry currently recommends adjusting pediatric bone density Z-scores by race, sex, and age. However, race-based adjustments risk reinforcing disparities and perpetuating systemic inequities in pediatric bone health assessment. We conducted a scoping review of studies examining racial and ethnic differences in BMD among healthy US children, identifying 3960 records across 4 databases, of which 54 met inclusion criteria. Across these studies, reporting of race and ethnicity was inconsistent: although nearly all relied on self- or parent-report, none provided explicit definitions, and only 13% confirmed concordance across grandparents. Fifty percent of studies reported statistically significant racial differences in BMD, yet most did so without comprehensive covariate adjustment. By contrast, studies that accounted for height, lean mass, and pubertal status frequently found that differences attenuated or disappeared. These findings underscore the need to critically reconsider race-based adjustments in pediatric DXA interpretation. Developing and validating race-neutral reference standards, with attention to structural determinants and biologically relevant measures, such as stature, body composition, and pubertal timing, is essential for achieving a more equitable and clinically meaningful assessment of pediatric bone health. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research. FAU - Ramadan, Amira AU - Ramadan A AD - Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. FAU - Moore, Zakora AU - Moore Z AD - Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. FAU - Ahmed, Usman A AU - Ahmed UA AD - Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. FAU - Tantivit, Nessa AU - Tantivit N AD - Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. FAU - Aiylam, Dhriti AU - Aiylam D AD - Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. FAU - Rotman, Chloe AU - Rotman C AD - Medical Library, Boston Children's Hospital, Boston, MA 02115, United States. FAU - Pendleton, Alicia AU - Pendleton A AD - Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. FAU - Petty, Carter R AU - Petty CR AD - Biostatistics and Research Design (BARD) Center, Boston Children's Hospital, Boston, MA 02115, United States. FAU - DiMeo, Mali AU - DiMeo M AD - Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. FAU - Grice, Amanda AU - Grice A AD - Office of Health Equity and Inclusion, Sandra L. Fenwick Institute for Pediatric Health Equity and Inclusion, Department of Health Affairs, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. FAU - Ward, Valerie L AU - Ward VL AD - Office of Health Equity and Inclusion, Sandra L. Fenwick Institute for Pediatric Health Equity and Inclusion, Department of Health Affairs, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. AD - Department of Radiology, Boston Children's Hospital and Harvard Medical School, Boston, MA, 02115 United States. FAU - Jacobsen, Christina M AU - Jacobsen CM AD - Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. FAU - Renthal, Nora E AU - Renthal NE AUID- ORCID: 0000-0002-8186-4462 AD - Department of Pediatrics, Division of Endocrinology, Boston Children's Hospital and Harvard Medical School, Boston, MA 02115, United States. LA - eng GR - T32 DK007260/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Review DEP - 20260312 PL - England TA - JBMR Plus JT - JBMR plus JID - 101707013 PMC - PMC13007872 OTO - NOTNLM OT - BMD OT - DXA OT - ethnicity OT - health disparities OT - normative curves OT - pediatric bone density OT - pediatric reference data OT - race COIS- The authors declare no conflicts of interest. EDAT- 2026/03/25 07:09 MHDA- 2026/03/25 07:10 PMCR- 2026/03/12 CRDT- 2026/03/25 04:27 PHST- 2025/09/29 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/02/16 00:00 [accepted] PHST- 2026/03/25 07:10 [medline] PHST- 2026/03/25 07:09 [pubmed] PHST- 2026/03/25 04:27 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - ziag028 [pii] AID - 10.1093/jbmrpl/ziag028 [doi] PST - epublish SO - JBMR Plus. 2026 Mar 12;10(4):ziag028. doi: 10.1093/jbmrpl/ziag028. eCollection 2026 Apr. PMID- 41877483 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20261028 IS - 1525-0024 (Electronic) IS - 1525-0016 (Print) IS - 1525-0016 (Linking) VI - 34 IP - 7 DP - 2026 Jul 1 TI - A cartilage-targeted IGF-1-antibody fusion protein as a new therapeutic approach for IGF-1 deficiency. PG - 4169-4180 LID - S1525-0016(26)00205-4 [pii] LID - 10.1016/j.ymthe.2026.03.020 [doi] AB - Growth hormone (GH) insensitivity syndrome (GHIS) is a childhood growth disorder characterized by an inability to generate insulin-like growth factor-1 (IGF-1) in response to GH. Consequently, GH therapy is ineffective in patients with GHIS. Patients are often treated with recombinant IGF-1 instead, which requires twice-daily injections and is associated with adverse effects including hypoglycemia. In the current study, we evaluated CV1623-1, a cartilage-targeted antibody-like IGF-1 fusion protein as a potential new treatment for GHIS and for other disorders of linear growth involving IGF-1 deficiency. Using Ghrhr(lit) mice as a model for IGF-1 deficiency, we found that CV1623-1 stimulated the growth plate at a lower dose and decreased dose frequency compared with IGF-1. Alternate-day injections of CV1623-1 significantly increased body weight, tail length, and tibial bone length. In addition, CV1623-1, unlike IGF-1, did not induce hypoglycemia. Taken together, our findings indicate that CV1623-1 represents a promising new drug candidate for GHIS with improved efficacy, longer duration of action, and reduced hypoglycemia compared with the current treatment, recombinant IGF-1. Preclinical studies and clinical trials would be required to further validate the safety and efficacy of CV1623-1, paving the way for its potential clinical application as a new treatment for GHIS. CI - Published by Elsevier Inc. FAU - Tailor, Krishma AU - Tailor K AD - Section on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892, USA; Cavalry Biosciences, Inc., San Francisco, CA 94107, USA. FAU - Stowe, Timothy AU - Stowe T AD - Cavalry Biosciences, Inc., San Francisco, CA 94107, USA. FAU - Hansdah, Kirtal AU - Hansdah K AD - Section on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892, USA. FAU - Courtis, Joanna AU - Courtis J AD - Section on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892, USA. FAU - Rama-Krishnan, Arun AU - Rama-Krishnan A AD - Section on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892, USA. FAU - Sisk, Connor AU - Sisk C AD - Section on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892, USA. FAU - van Ree, Janine AU - van Ree J AD - Cavalry Biosciences, Inc., San Francisco, CA 94107, USA. FAU - van Deursen, Jan AU - van Deursen J AD - Cavalry Biosciences, Inc., San Francisco, CA 94107, USA. FAU - Ventura, Brit AU - Ventura B AD - Cavalry Biosciences, Inc., San Francisco, CA 94107, USA. FAU - O'Brien, Robert AU - O'Brien R AD - Cavalry Biosciences, Inc., San Francisco, CA 94107, USA. FAU - Baron, Jeffrey AU - Baron J AD - Section on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892, USA. FAU - Lui, Julian C AU - Lui JC AD - Section on Growth and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD 20892, USA. Electronic address: julian.lui@nih.gov. LA - eng GR - R43 HD112213/HD/NICHD NIH HHS/United States GR - Z99 HD999999/ImNIH/Intramural NIH HHS/United States GR - ZIA HD000640/ImNIH/Intramural NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Intramural DEP - 20260324 PL - United States TA - Mol Ther JT - Molecular therapy : the journal of the American Society of Gene Therapy JID - 100890581 RN - 67763-96-6 (Insulin-Like Growth Factor I) RN - 0 (Recombinant Fusion Proteins) RN - Insulin-Like Growth Factor I Deficiency SB - IM MH - Animals MH - *Insulin-Like Growth Factor I/deficiency/genetics MH - Mice MH - *Recombinant Fusion Proteins/pharmacology/genetics/administration & dosage MH - *Cartilage/metabolism/drug effects MH - Humans MH - Disease Models, Animal MH - Growth Plate/drug effects/metabolism MH - *Laron Syndrome/drug therapy/metabolism/genetics MH - Female MH - Growth Disorders MH - Hearing Loss, Sensorineural PMC - PMC13147239 MID - NIHMS2165333 OTO - NOTNLM OT - Fab domain OT - bispecific antibody OT - hypoglycemia OT - short stature OT - skeletal dysplasia COIS- Declaration of interests R.O.B., T.S., J.v.R., B.V., J.v.D., and K.T. were employees of Cavalry Biosciences and have a financial interest in CV1623-1 and related molecules. J.B., and J.C.L. are inventors of a patent licensed by Cavalry Biosciences related to CV1623-1 and received research support for this work from Cavalry Biosciences under a Cooperative Research and Development Agreement. EDAT- 2026/03/25 07:09 MHDA- 2026/07/02 00:33 PMCR- 2027/07/01 CRDT- 2026/03/25 02:36 PHST- 2025/04/29 00:00 [received] PHST- 2026/01/27 00:00 [revised] PHST- 2026/03/17 00:00 [accepted] PHST- 2026/07/02 00:33 [medline] PHST- 2026/03/25 07:09 [pubmed] PHST- 2026/03/25 02:36 [entrez] PHST- 2027/07/01 00:00 [pmc-release] AID - S1525-0016(26)00205-4 [pii] AID - 10.1016/j.ymthe.2026.03.020 [doi] PST - ppublish SO - Mol Ther. 2026 Jul 1;34(7):4169-4180. doi: 10.1016/j.ymthe.2026.03.020. Epub 2026 Mar 24. PMID- 41877298 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260627 LR - 20260813 IS - 2200-6133 (Print) IS - 2200-6133 (Electronic) IS - 2200-6133 (Linking) VI - 18 IP - 1 DP - 2026 Mar 25 TI - Prognosis of clinical pneumonia in undernourished children in rural Gambia. LID - 10.1186/s41479-025-00194-8 [doi] LID - 8 AB - BACKGROUND: Undernutrition significantly increases the risk of severe infections and mortality in children under five, particularly in low- and middle-income countries. Pneumonia, a leading cause of childhood death, is especially dangerous in undernourished children, yet prognostic measures to identify those at highest risk are lacking. OBJECTIVE: To identify algorithms of poor prognosis in undernourished children with clinical pneumonia for early identification of children at risk for poor outcomes. METHODS: This study analyzed a subset of children enrolled in a cohort designed to identify biomarkers of bacterial pneumonia. Children aged 2-59 months with clinical pneumonia were recruited from two rural Gambian hospitals. Clinical and anthropometric data were collected at baseline, during hospitalization, and at 30-day follow-up. Nutritional status was classified using WHO definitions for stunting (height-for-age Z-scores) and wasting (weight-for-height Z-scores) as severe (Z-scores /= Z-scores > -3), and mild (-1 >/= Z-scores > -2). Prognostic outcomes were classified into good and poor. Poor prognosis included death, prolonged hospital stay (>/= 7 days), post-discharge care-seeking, and difficult to feed during admission. Good prognosis was based on a hospital stay < 3 days, with good outcomes within 30 days of the initial visit. Classification tree models and penalized logistic regression models (fit through elastic net) were used to identify combinations of predictors of poor prognosis (prognostic signatures). RESULTS: A total of 246 children with clinical pneumonia and undernutrition (wasting or stunting) were included. Children with poor prognosis presented more frequently with respiratory distress, hypoxemia, reduced capacity oforal feeding difficulty, and anemia. As expected, undernutrition was associated with adverse outcomes. The final prognostic algorithms were accurate to identify undernourished children at risk of poor prognosis: with sensitivity and specificity > 80% and area under the receiver operating characteristic curve >/= 0.80. Furthermore, we identified accurate prognostic signatures among children with both wasting and stunting. CONCLUSION: Measures collected at admission in undernourished children with clinical pneumonia can identify those at risk of poor outcomes. The prognostic signatures developed in this study may inform early risk stratification and guide timely intervention, particularly in resource-limited settings. FAU - Isa, Yasir Shitu AU - Isa YS AD - Medical Research Council Unit, The Gambia, London School of Hygiene & Tropical Medicine, Fajara, The Gambia. yasirshitu@gmail.com. FAU - Carelus, Megan AU - Carelus M AD - Boston University School of Public Health, Boston, MA, USA. FAU - Silber, Isabelle AU - Silber I AD - Boston University School of Public Health, Boston, MA, USA. FAU - Salaudeen, Rasheed AU - Salaudeen R AD - Medical Research Council Unit, The Gambia, London School of Hygiene & Tropical Medicine, Fajara, The Gambia. FAU - Sarwar, Golam AU - Sarwar G AD - Medical Research Council Unit, The Gambia, London School of Hygiene & Tropical Medicine, Fajara, The Gambia. FAU - Olatunji, Yekini Ajao AU - Olatunji YA AD - Medical Research Council Unit, The Gambia, London School of Hygiene & Tropical Medicine, Fajara, The Gambia. FAU - Hossain, Ilias AU - Hossain I AD - Medical Research Council Unit, The Gambia, London School of Hygiene & Tropical Medicine, Fajara, The Gambia. FAU - Osei, Isaac AU - Osei I AD - Medical Research Council Unit, The Gambia, London School of Hygiene & Tropical Medicine, Fajara, The Gambia. AD - Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK. FAU - Lobga, Galega AU - Lobga G AD - Medical Research Council Unit, The Gambia, London School of Hygiene & Tropical Medicine, Fajara, The Gambia. FAU - Adeshola, Banjo AU - Adeshola B AD - Medical Research Council Unit, The Gambia, London School of Hygiene & Tropical Medicine, Fajara, The Gambia. FAU - Barjo, Ousman AU - Barjo O AD - Medical Research Council Unit, The Gambia, London School of Hygiene & Tropical Medicine, Fajara, The Gambia. FAU - Drammeh, Momodou M AU - Drammeh MM AD - Medical Research Council Unit, The Gambia, London School of Hygiene & Tropical Medicine, Fajara, The Gambia. FAU - D'Alessandro, Umberto AU - D'Alessandro U AD - Medical Research Council Unit, The Gambia, London School of Hygiene & Tropical Medicine, Fajara, The Gambia. AD - Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK. FAU - Hibberd, Patricia L AU - Hibberd PL AD - Boston University School of Public Health, Boston, MA, USA. FAU - Mackenzie, Grant A AU - Mackenzie GA AD - Medical Research Council Unit, The Gambia, London School of Hygiene & Tropical Medicine, Fajara, The Gambia. gmackenzie@mrc.gm. AD - Faculty of Infectious and Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK. gmackenzie@mrc.gm. FAU - Valim, Clarissa AU - Valim C AD - Department of Global Health, Boston University School of Public Health, Boston, MA, USA. cvalim@bu.edu. LA - eng PT - Journal Article DEP - 20260325 PL - England TA - Pneumonia (Nathan) JT - Pneumonia (Nathan Qld.) JID - 101663459 PMC - PMC13014833 COIS- Declarations. Ethics approval and consent to participate: Written informed consent was obtained from the parents or legal guardians of the participants. The study was approved by the Gambia Government/MRCG Joint Ethics Committee (protocol 1616) and the institutional review board of Boston University Medical Centre (STUDY00000958). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/25 07:09 MHDA- 2026/03/25 07:10 PMCR- 2026/03/25 CRDT- 2026/03/25 00:58 PHST- 2025/07/22 00:00 [received] PHST- 2025/12/30 00:00 [accepted] PHST- 2026/03/25 07:10 [medline] PHST- 2026/03/25 07:09 [pubmed] PHST- 2026/03/25 00:58 [entrez] PHST- 2026/03/25 00:00 [pmc-release] AID - 10.1186/s41479-025-00194-8 [pii] AID - 194 [pii] AID - 10.1186/s41479-025-00194-8 [doi] PST - epublish SO - Pneumonia (Nathan). 2026 Mar 25;18(1):8. doi: 10.1186/s41479-025-00194-8. PMID- 41877077 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Mar 25 TI - Food systems and market pathways to childhood stunting in mining communities: evidence from a cross-sectional survey and a synthesis of context-responsive nutrition interventions. LID - 10.1186/s12889-026-26835-1 [doi] LID - 1443 AB - PURPOSE: Malnutrition remains a persistent global and public health challenge, with limited evidence available on the synthesis of empirical findings and feasibility of nutrition interventions across various settings, particularly in vulnerable mining communities. This study used empirical data, corresponding it with existing interventions to provide a benchmark for selecting effective nutrition strategies, thereby optimizing their impact. METHODS: This study used a cross-sectional design and evidence review of nutrition interventions to discuss the results. The target population included under-five children and their caregivers. The study had a sample size of 690 and used multistage random sampling technique to select participants. Data collection involved structured questionnaires, direct child measurements, and interviews. Anthropometric data used WHO standards to assess underweight. Statistical analyses included descriptive statistics and chi-square tests while evaluating context-specific nutrition interventions for their effectiveness and feasibility. RESULTS: The study findings reveal a statistical significant association between owning a vegetable garden (P = 0.002), access to a market/farmers market (p < 0.001), access to income to buy food (P = 0.034), availability of food products (p < 0.001), access to main grocery store (p < 0.001), training in agriculture (p < 0.001), feeding strategies (p < 0.001) and under-five stunting. Based on the empirical data and analytical review of nutrition interventions, the following strategies are recommended: Community Nutrition Education Programs, Nutrition-Sensitive Social Protection Programs, Nutrition-Focused Community Health Workers (CHWs), Digital Health and Nutrition Platforms and Local Food System Development. Integrating these interventions with the study's findings will enhance their effectiveness and maximize impact. CONCLUSION: The findings display the complex interplay of factors affecting child stunting and health. Findings emphasize the importance of considering diverse contextual factors, intervention intensity, and the integration of food system transformation to optimize the impact of nutrition interventions. FAU - Nyirenda, Herbert Tato AU - Nyirenda HT AD - School of Medicine, Department of Public Health, The Copperbelt University, Ndola, Zambia. tatonyirenda@gmail.com. FAU - Mulenga, David AU - Mulenga D AD - School of Medicine, Department of Public Health, The Copperbelt University, Ndola, Zambia. FAU - Nyirenda, Tambulani Chayima AU - Nyirenda TC AD - School of Humanities and Social Sciences, Department of Government and Management Studies, The university of Zambia, Lusaka, Zambia. FAU - Sinyangwe, Hilda Teza AU - Sinyangwe HT AD - School of Social Sciences, Economics Department, Mulungushi University, Kabwe, Zambia. FAU - Choka, Nancy AU - Choka N AD - School of Humanities and Social Sciences, Department of Government and Management Studies, The university of Zambia, Lusaka, Zambia. FAU - Nyambe-Silavwe, Hilda AU - Nyambe-Silavwe H AD - Department of Food Science and Nutrition, The University of Zambia, Lusaka, Zambia. LA - eng PT - Journal Article DEP - 20260325 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Child, Preschool MH - Infant MH - *Growth Disorders/epidemiology/prevention & control MH - Female MH - Male MH - *Mining MH - *Food Supply/statistics & numerical data MH - Surveys and Questionnaires MH - *Food Markets PMC - PMC13137554 OTO - NOTNLM OT - Food markets OT - Mining communities OT - Nutrition intervention OT - Stunting OT - Under-five children COIS- Declarations. Ethics approval and consent to participate: The study involving human participants and human data was conducted in accordance with the ethical principles of the Declaration of Helsinki as established by the World Medical Association. Ethical clearance was sought from the Copperbelt University Biomedical Research Committee (CBUBREC) study number CBU/BREC/23/001 to conduct the study. The institutional review board conducted a thorough full review of the protocol upon which approval was granted. Participation was voluntary (freely-given) and participants were informed about facets of the study. We confirm that informed consent to participate and publish were obtained from all parents/or legal guardian of under-five children. Therefore, the study adhered to all ethical guidelines. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/25 07:09 MHDA- 2026/06/28 06:35 PMCR- 2026/03/25 CRDT- 2026/03/25 00:47 PHST- 2024/08/31 00:00 [received] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/06/28 06:35 [medline] PHST- 2026/03/25 07:09 [pubmed] PHST- 2026/03/25 00:47 [entrez] PHST- 2026/03/25 00:00 [pmc-release] AID - 10.1186/s12889-026-26835-1 [pii] AID - 26835 [pii] AID - 10.1186/s12889-026-26835-1 [doi] PST - epublish SO - BMC Public Health. 2026 Mar 25;26(1):1443. doi: 10.1186/s12889-026-26835-1. PMID- 41876144 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 2056-5933 (Electronic) IS - 2056-5933 (Linking) VI - 12 IP - 1 DP - 2026 Mar 24 TI - Severe impairments in work ability among patients with axSpA and PsA: results from the RABBIT-SpA Register. LID - 10.1136/rmdopen-2025-006338 [doi] LID - e006338 AB - OBJECTIVES: To assess the frequency and extent of work ability impairment and explore differences in its degree in relation to sociodemographic, clinical and patient-reported factors in patients with axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA). METHODS: This cross-sectional analysis used data from the prospective RABBIT-SpA cohort, including patients aged 18-65 years with physician-confirmed axSpA or PsA. Work ability was assessed in both the axSpA and PsA cohorts using the Work Ability Index (WAI; 7-49 points, higher scores=better work ability), categorised as good/excellent (>/=37) or moderate/poor (70%, and mortality >50%, while low-risk neonates (>32 weeks, >1,500 g, Apgar > 5) showed favorable trajectories. CONCLUSION: This study demonstrates that LLMs can synthesize medical literature and extract clinically relevant prognostic variables for neonatal IVH outcomes. However, LLM outputs were susceptible to hallucinations and incomplete data synthesis, underscoring the need for rigorous clinical oversight and human validation to ensure reliability. The identified universal predictors provide a foundation for developing AI-assisted clinical decision support tools. Notable research gaps include the complete absence of resolution prediction studies and limited investigation of complication predictors, highlighting opportunities for future investigation in precision neonatology. KEY POINTS: . LLMs can synthesize medical literature. . LLMs can assist in creating a prognostic ontology. . Human oversight is critical when using LLMs for healthcare. CI - Thieme. All rights reserved. FAU - Arora, Tanima AU - Arora T AUID- ORCID: 0000-0003-4918-5352 AD - Division of Newborn Medicine, Boston Children's Hospital, Boston, Massachusetts, United States. FAU - Beam, Kristyn AU - Beam K AUID- ORCID: 0000-0001-8245-0440 AD - Division of Neonatology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260323 PL - United States TA - Am J Perinatol JT - American journal of perinatology JID - 8405212 SB - IM MH - Humans MH - *Large Language Models MH - Infant, Newborn MH - Prognosis MH - Pilot Projects MH - Gestational Age MH - Infant, Premature MH - *Cerebral Intraventricular Hemorrhage/mortality MH - Risk Assessment MH - Birth Weight MH - Generative Artificial Intelligence COIS- The authors declare that they have no conflict of interest. EDAT- 2026/03/24 00:30 MHDA- 2026/10/01 23:29 CRDT- 2026/03/23 19:53 PHST- 2026/10/01 23:29 [medline] PHST- 2026/03/24 00:30 [pubmed] PHST- 2026/03/23 19:53 [entrez] AID - 10.1055/a-2838-5446 [doi] PST - ppublish SO - Am J Perinatol. 2026 Oct;43(14):1904-1912. doi: 10.1055/a-2838-5446. Epub 2026 Mar 23. PMID- 41871534 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260821 IS - 1932-2968 (Electronic) IS - 1932-2968 (Linking) VI - 20 IP - 3 DP - 2026 May TI - Development of a Calculator for HNF1A- and HNF4A-MODY in Asian Indians. PG - 751-760 LID - 10.1177/19322968261429944 [doi] AB - AIM: We aimed to develop a calculator to determine the probability of having HNF1A-MODY (hepatocyte nuclear factor 1 alpha-maturity-onset diabetes of the young) or HNF4A (hepatocyte nuclear factor 4 alpha)-MODY (the commonest forms of MODY) in Asian Indians using clinical and biochemical criteria. METHODS: We extracted data on individuals with young-onset diabetes aged <30 years (n = 29 191) from electronic records. Genetically confirmed HNF1A- and HNF4A-MODY (n = 55) were selected along with 1000 individuals each of type 1 diabetes (T1D) and type 2 diabetes (T2D). These data sets were used to develop a classification model using logistic regression. The model's performance was evaluated using receiver operating characteristic (ROC) curves in an internal data set and validated in an external data set. RESULTS: Eight predictive models were constructed, beginning with a basic model that included variables, such as age at diagnosis, body mass index (BMI), parental history, and glycated hemoglobin (HbA1c) (models 1 and 5). High-density lipoprotein (HDL) cholesterol was added in models 2 and 6, stimulated C-peptide in models 3 and 7, and all predictors were combined in models 4 and 8. Models 1 to 4, designed to distinguish MODY from T1D, achieved an ROC-area under the curve (AUC) value ranging from 0.884 to 0.957, while models 5 to 8, aimed at differentiating MODY from T2D, achieved an ROC-AUC value ranging from 0.914 to 0.936. All models demonstrated excellent performance in internal validation, with high five-fold cross-validation c-statistics. An online calculator using these models estimates MODY probability that is accessible at https://mdrf-t1d-calculator.shinyapps.io/MODY/. CONCLUSION: We developed an ethnicity-specific calculator to help identify individuals with possible HNF1A-MODY or HNF4A-MODY in Asian Indians. This user-friendly, web-based tool would be helpful to select candidates for genetic testing in this population. FAU - Mohan, Viswanathan AU - Mohan V AUID- ORCID: 0000-0001-5038-6210 AD - Madras Diabetes Research Foundation (ICMR Collaborating Centre of Excellence), Chennai, India. AD - Dr. Mohan's Diabetes Specialities Centre (IDF Centre of Excellence in Diabetes Care), Chennai, India. FAU - Venkatesan, Ulagamadesan AU - Venkatesan U AUID- ORCID: 0000-0002-1638-6046 AD - Madras Diabetes Research Foundation (ICMR Collaborating Centre of Excellence), Chennai, India. FAU - Amutha, Anandakumar AU - Amutha A AUID- ORCID: 0000-0002-9974-889X AD - Madras Diabetes Research Foundation (ICMR Collaborating Centre of Excellence), Chennai, India. FAU - Aarthy, Ramasamy AU - Aarthy R AUID- ORCID: 0000-0003-1291-3627 AD - Madras Diabetes Research Foundation (ICMR Collaborating Centre of Excellence), Chennai, India. FAU - Radha, Venkatesan AU - Radha V AD - Madras Diabetes Research Foundation (ICMR Collaborating Centre of Excellence), Chennai, India. FAU - Pande, Arunkumar AU - Pande A AUID- ORCID: 0000-0002-9570-1509 AD - Lucknow Endocrine Diabetes and Thyroid Clinic, Lucknow, India. AD - Health City Vistaar Hospital, Lucknow, India. FAU - Anjana, Ranjit Mohan AU - Anjana RM AUID- ORCID: 0000-0002-4843-1374 AD - Madras Diabetes Research Foundation (ICMR Collaborating Centre of Excellence), Chennai, India. AD - Dr. Mohan's Diabetes Specialities Centre (IDF Centre of Excellence in Diabetes Care), Chennai, India. FAU - Unnikrishnan, Ranjit AU - Unnikrishnan R AD - Madras Diabetes Research Foundation (ICMR Collaborating Centre of Excellence), Chennai, India. AD - Dr. Mohan's Diabetes Specialities Centre (IDF Centre of Excellence in Diabetes Care), Chennai, India. LA - eng PT - Journal Article DEP - 20260323 PL - United States TA - J Diabetes Sci Technol JT - Journal of diabetes science and technology JID - 101306166 RN - 0 (Hepatocyte Nuclear Factor 1-alpha) RN - 0 (Hepatocyte Nuclear Factor 4) RN - 0 (HNF1A protein, human) RN - 0 (HNF4A protein, human) RN - Mason-Type Diabetes RN - Indian people SB - IM MH - Adolescent MH - Adult MH - Child MH - Female MH - Humans MH - Male MH - Young Adult MH - Diabetes Mellitus, Type 1/genetics/diagnosis MH - *Diabetes Mellitus, Type 2/genetics/diagnosis/ethnology MH - *Hepatocyte Nuclear Factor 1-alpha/genetics MH - *Hepatocyte Nuclear Factor 4/genetics MH - India/epidemiology MH - ROC Curve MH - South Asian People/genetics PMC - PMC13008792 OTO - NOTNLM OT - Asian Indians OT - MODY OT - logistic regression OT - prediction models OT - type 1 diabetes OT - type 2 diabetes COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/03/24 00:30 MHDA- 2026/05/01 06:34 PMCR- 2027/03/23 CRDT- 2026/03/23 19:12 PHST- 2026/05/01 06:34 [medline] PHST- 2026/03/24 00:30 [pubmed] PHST- 2026/03/23 19:12 [entrez] PHST- 2027/03/23 00:00 [pmc-release] AID - 10.1177_19322968261429944 [pii] AID - 10.1177/19322968261429944 [doi] PST - ppublish SO - J Diabetes Sci Technol. 2026 May;20(3):751-760. doi: 10.1177/19322968261429944. Epub 2026 Mar 23. PMID- 41871087 OWN - NLM STAT- MEDLINE DCOM- 20260323 LR - 20260330 IS - 1940-087X (Electronic) IS - 1940-087X (Linking) IP - 229 DP - 2026 Mar 3 TI - Application of a Refined Nursing Model in Children with Mycoplasma Pneumonia. LID - 10.3791/68945 [doi] AB - This research aims to demonstrate and explain a meticulous care plan applicable to Mycoplasma pneumonia (MP) in children. This plan integrates multi-dimensional measures such as psychological care, respiratory tract management, dietary guidance, fever care and health education, forming a structured care path. A total of 122 children with MP admitted from May to September 2023 were selected for the study. They were divided into the experimental group and the control group by random number table method, with 61 cases in each group. The control group received routine care, while the experimental group received meticulous care on the basis of routine care. The plan mainly describes the story-telling communication skills in psychological care, the standard operation of nebulization inhalation parameters and back tapping in respiratory care, the hierarchical monitoring and treatment of fever, as well as the modular health education content for caregivers. The results show that meticulous care can promote symptom relief in children, reduce inflammatory indicators, enhance disease awareness and nursing satisfaction, verifying the feasibility and positive role of this nursing plan in clinical practice. This study provides a replicable and scalable operational framework for the systematic care of MP in children. FAU - Yang, Ju-Hui AU - Yang JH AD - Department of Emergency, Hai'an Traditional Chinese Medicine Hospital in Jiangsu Province. FAU - Xu, Ping AU - Xu P AD - Department of Emergency, Hai'an Traditional Chinese Medicine Hospital in Jiangsu Province. FAU - You, Xia AU - You X AD - Department of Emergency, Hai'an Traditional Chinese Medicine Hospital in Jiangsu Province. FAU - Kang, Qun AU - Kang Q AD - Department of Nursing, Hai'an Traditional Chinese Medicine Hospital in Jiangsu Province; qunkuan33@yeah.net. LA - eng PT - Journal Article PT - Video-Audio Media DEP - 20260303 PL - United States TA - J Vis Exp JT - Journal of visualized experiments : JoVE JID - 101313252 SB - IM MH - Humans MH - *Pneumonia, Mycoplasma/nursing MH - Child MH - Female MH - Male MH - Child, Preschool EDAT- 2026/03/23 19:53 MHDA- 2026/03/23 19:54 CRDT- 2026/03/23 13:35 PHST- 2026/03/23 19:54 [medline] PHST- 2026/03/23 19:53 [pubmed] PHST- 2026/03/23 13:35 [entrez] AID - 10.3791/68945 [doi] PST - epublish SO - J Vis Exp. 2026 Mar 3;(229). doi: 10.3791/68945. PMID- 41871023 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 3 DP - 2026 TI - Reliability and validity of the Sinhala version of the physical activity questionnaire for older children (PAQ-C). PG - e0343709 LID - 10.1371/journal.pone.0343709 [doi] LID - e0343709 AB - INTRODUCTION: In Sri Lanka, as non-communicable diseases rise, the significance of physical activity is increasingly recognised, particularly in children. The Physical Activity Questionnaire for Older Children (PAQ-C) is widely used and can be considered as one of the best available tools for assessing physical activity in children. However, a validated tool for Sinhala-speaking children in Sri Lanka has been lacking. This study aims to culturally adapt and validate the PAQ-C for Sinhala-speaking children and evaluate its psychometric properties. METHODOLOGY: This cross-sectional study involved 301 schoolchildren (197 males and 104 females) aged 8-11 years, during which the PAQ-C was translated into Sinhala, and a pre-final version was developed. In terms of validity, content validity, that is, the degree to which the content of an instrument is an adequate reflection of the construct to be measured, was assessed using the content validity index. In terms of reliability, test-retest reliability was measured with the intraclass correlation coefficient (ICC). RESULTS: The Sinhala version of the PAQ-C demonstrated CVI at both item and scale levels is as one. The ICC was acceptable at 0.83. CONCLUSION: The Sinhala version of the PAQ-C demonstrates good content validity and acceptable test-retest reliability, affirming its suitability as a cost-effective tool for assessing physical activity levels among Sinhala-speaking children in Sri Lanka and supporting informed interventions and public health strategies in the country. CI - Copyright: (c) 2026 Liyanage et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Liyanage, E AU - Liyanage E AD - Department of Physiotherapy, Faculty of Allied Health Sciences, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Jayasinghe, C AU - Jayasinghe C AD - Department of Physical Therapy, Niigata University of Health and Welfare, Niigata, Japan. FAU - Liyanage, I AU - Liyanage I AUID- ORCID: 0000-0002-8352-9182 AD - Department of Physiotherapy, Faculty of Allied Health Sciences, University of Peradeniya, Peradeniya, Sri Lanka. LA - eng PT - Journal Article PT - Validation Study DEP - 20260323 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Child MH - Female MH - Surveys and Questionnaires MH - Sri Lanka MH - Reproducibility of Results MH - Male MH - Psychometrics MH - Cross-Sectional Studies MH - *Exercise MH - *Motor Activity PMC - PMC13008094 COIS- The authors have declared that no competing interests exist. EDAT- 2026/03/23 19:53 MHDA- 2026/03/23 19:54 PMCR- 2026/03/23 CRDT- 2026/03/23 13:24 PHST- 2025/09/03 00:00 [received] PHST- 2026/02/10 00:00 [accepted] PHST- 2026/03/23 19:54 [medline] PHST- 2026/03/23 19:53 [pubmed] PHST- 2026/03/23 13:24 [entrez] PHST- 2026/03/23 00:00 [pmc-release] AID - PONE-D-25-42509 [pii] AID - 10.1371/journal.pone.0343709 [doi] PST - epublish SO - PLoS One. 2026 Mar 23;21(3):e0343709. doi: 10.1371/journal.pone.0343709. eCollection 2026. PMID- 41870802 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 1678-4405 (Electronic) IS - 1517-8382 (Print) IS - 1517-8382 (Linking) VI - 57 IP - 1 DP - 2026 Mar 23 TI - Designing a novel and effective multi-epitope subunit vaccine against human astrovirus using reverse vaccinology approach. LID - 10.1007/s42770-026-01885-0 [doi] LID - 90 AB - Gastroenteritis, a condition often seen in children, is mostly attributed to the human Astro virus (HAstVs). This viral infection typically manifests via symptoms like as diarrhea and vomiting, which may subsequently result in dehydration and malnutrition in children aged below five years. Pathogens spread via fecal-oral pathway. However, it does not exhibit zoonotic potential. Diarrhea affects more children worldwide than malaria, AIDS, and measles combined. Statistically diarrheal illness kills 1 in 9 children globally, and eight lack annually. The treatment of HAstVs infection remains enigmatic due to the absence of efficacious antiviral medication or vaccines designed to eliminate the infection. Therefore, it is imperative to produce an effective vaccine to address this illness. The primary aim of our ongoing research is to formulate and construct a multi-epitope vaccine via immunoinformatics approach. This vaccine will be based on non-structural polyprotein 1a and capsid polyprotein vp90 of HAstVs. Using specific selection parameters, putative epitopes from the above-mentioned HAstVs proteome were examined. The epitopes that were selected for further consideration were then combined by including appropriate adjuvant and linkers. Importantly, the physicochemical characteristics, and structural validation of the vaccine construct yielded good result. Additionally, the immune simulation study of the vaccine complexes also had noteworthy outcomes. Moreover, the molecular docking and molecular dynamic simulation analysis of the final construct demonstrated an enhanced affinity towards toll-like receptor-3. Finally, the outcomes of Insilco studies were satisfied. In summary, we are optimistic that our anticipated vaccination model demonstrates positive results in wet laboratory verification and make it easier to treat gastroenteritis infection in future. FAU - Khan, Suliman AU - Khan S AD - Centre for Biotechnology and Microbiology, University of Swat, Mingora, KPK, 19200, Pakistan. FAU - Khan, Ishaq AU - Khan I AD - Centre for Biotechnology and Microbiology, University of Swat, Mingora, KPK, 19200, Pakistan. FAU - Ali, Syed Shujait AU - Ali SS AD - Centre for Biotechnology and Microbiology, University of Swat, Mingora, KPK, 19200, Pakistan. FAU - Hussain, Zahid AU - Hussain Z AD - Centre for Biotechnology and Microbiology, University of Swat, Mingora, KPK, 19200, Pakistan. FAU - Ali, Shahid AU - Ali S AD - Centre for Biotechnology and Microbiology, University of Swat, Mingora, KPK, 19200, Pakistan. FAU - Iqbal, Arshad AU - Iqbal A AUID- ORCID: 0000-0002-0403-6524 AD - Centre for Biotechnology and Microbiology, University of Swat, Mingora, KPK, 19200, Pakistan. arshad.iqbal@uswat.edu.pk. LA - eng PT - Journal Article DEP - 20260323 PL - Brazil TA - Braz J Microbiol JT - Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] JID - 101095924 RN - 0 (Viral Vaccines) RN - 0 (Vaccines, Subunit) RN - 0 (Protein Subunit Vaccines) RN - 0 (Epitopes) SB - IM MH - Humans MH - *Mamastrovirus/immunology/genetics MH - Reverse Vaccinology MH - *Astroviridae Infections/prevention & control/virology/immunology MH - *Viral Vaccines/immunology/genetics/chemistry MH - Vaccines, Subunit/immunology/genetics/chemistry MH - Protein Subunit Vaccines MH - *Epitopes/immunology/genetics/chemistry MH - Vaccine Development MH - Molecular Docking Simulation MH - Immunoinformatics PMC - PMC13009431 OTO - NOTNLM OT - Gastroenteritis OT - Human astrovirus (HAstV) OT - Immunoinformatics OT - Molecular docking OT - Multi-epitope vaccine OT - Toll-like receptor 3 (TLR3) COIS- Declarations. Conflict of interest: The authors declare no conflict of interest. EDAT- 2026/03/23 19:54 MHDA- 2026/06/27 16:09 PMCR- 2027/03/23 CRDT- 2026/03/23 12:21 PHST- 2024/09/22 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/06/27 16:09 [medline] PHST- 2026/03/23 19:54 [pubmed] PHST- 2026/03/23 12:21 [entrez] PHST- 2027/03/23 00:00 [pmc-release] AID - 10.1007/s42770-026-01885-0 [pii] AID - 1885 [pii] AID - 10.1007/s42770-026-01885-0 [doi] PST - epublish SO - Braz J Microbiol. 2026 Mar 23;57(1):90. doi: 10.1007/s42770-026-01885-0. PMID- 41870301 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260713 IS - 1533-4287 (Electronic) IS - 1064-8011 (Linking) VI - 40 IP - 6 DP - 2026 Jun 1 TI - Definition of Substantial Athletic Benefit and Satisfaction of a Neuromuscular and Strength Training Program for Ballet Dancers. PG - e629-e638 LID - 10.1519/JSC.0000000000005400 [doi] AB - Crampton, CT, Smith, ST, and Noyes, FR. Definition of substantial athletic benefit and satisfaction of a neuromuscular and strength training program for ballet dancers. J Strength Cond Res 40(6): e629-e638, 2026-The aim of this prospective cross-sectional study was to assess the psychometrics and performance outcomes on preprofessional ballet dancers undergoing a neuromuscular and strength training program. We hypothesized that ballet dancers would perceive substantial benefits of this training program and significantly improve performance outcomes. Twenty-eight dancers from a preprofessional ballet training program volunteered to participate in a 6-week neuromuscular and strength training program. The dancers completed a psychometric questionnaire and objective testing before and after the training program. The psychometric questionnaire evaluated individual substantial athletic benefits and satisfaction of the training program. Objective testing included the triple hop test and T-Drill hop test to assess the training program on improving horizontal distance hopped, time hopped, limb symmetry, and landing mechanics. The dancers reported high perceived substantial benefits in 79% (22 of 28) for teaching proper take-off and landing mechanics, and in 96% (27 of 28) for the program challenging and preparing them for dance activities. A high dancer satisfaction rating was reported in 93% (26 of 28 dancers) for the training program. A significant increase in distance hopped occurred in right and left lower limbs on the triple hop test ( p < 0.001). A significant decrease in time to complete the T-Drill hop test was reported on right and left lower limbs ( p < 0.001). The psychometric results of the high substantial athletic benefits, major overall satisfaction, and increased hop drill performance warrant the recommendation of this training program for ballet dancers. CI - Copyright (c) 2026 National Strength and Conditioning Association. FAU - Crampton, Carolyn T AU - Crampton CT AD - Cincinnati SportsMedicine Research and Education Foundation, Mercy Health, Cincinnati, Ohio. FAU - Smith, Stephanie T AU - Smith ST FAU - Noyes, Frank R AU - Noyes FR LA - eng PT - Journal Article DEP - 20260320 PL - United States TA - J Strength Cond Res JT - Journal of strength and conditioning research JID - 9415084 SB - IM MH - Humans MH - *Dancing/psychology/physiology MH - Female MH - *Resistance Training/methods MH - Cross-Sectional Studies MH - Prospective Studies MH - Young Adult MH - Psychometrics MH - *Personal Satisfaction MH - Male MH - Surveys and Questionnaires MH - *Athletic Performance/psychology/physiology MH - Adult MH - Adolescent OTO - NOTNLM OT - ballet neuromuscular training OT - ballet strength training OT - dance medicine OT - injury prevention OT - psychometric analysis EDAT- 2026/03/23 13:04 MHDA- 2026/05/22 12:34 CRDT- 2026/03/23 10:22 PHST- 2026/05/22 12:34 [medline] PHST- 2026/03/23 13:04 [pubmed] PHST- 2026/03/23 10:22 [entrez] AID - 00124278-990000000-00931 [pii] AID - 10.1519/JSC.0000000000005400 [doi] PST - ppublish SO - J Strength Cond Res. 2026 Jun 1;40(6):e629-e638. doi: 10.1519/JSC.0000000000005400. Epub 2026 Mar 20. PMID- 41868177 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260813 IS - 1177-8881 (Electronic) IS - 1177-8881 (Linking) VI - 20 DP - 2026 TI - Machine Learning Models Reveal New Risk Factors for Sub-/Supra-Therapeutic Concentrations of Sirolimus in Children with Vascular Anomalies. PG - 563637 LID - 10.2147/DDDT.S563637 [doi] LID - 563637 AB - INTRODUCTION: Sirolimus, also known as rapamycin, is an mTOR receptor inhibitor that suppresses cell proliferation and angiogenesis, demonstrating efficacy against multiple types of vascular anomalies. However, sub-therapeutic concentrations (below effective levels) and supra-therapeutic concentrations (leading to adverse reactions) of sirolimus may both negatively impact patient treatment outcomes. This study aimed to establish optimal models to predict the risk of sirolimus exposure using machine learning, ensure that sirolimus blood concentrations remain within the therapeutic range, and thus enhance the efficacy and safety of sirolimus therapy for children with vascular anomalies. METHODS: We retrospectively analyzed 134 sirolimus therapeutic drug monitoring (TDM) measurements from 49 patients. Data were randomly split into training (80%) and testing (20%) sets, with an additional temporal cohort for external validation. Six machine learning models were developed to predict sub-therapeutic and supra-therapeutic risks, and evaluated primarily by the area under the receiver operating characteristic curve (AUROC) and Brier score. The optimal model was interpreted using SHapley Additive exPlanations (SHAP) analysis. RESULTS: The sub-therapeutic risk model included body mass index (BMI), white blood cells (WBC), mean corpuscular hemoglobin (MCH), triglycerides (TG), and total bilirubin (TBIL); while the supra-therapeutic model comprised height, platelet count (PLT), alanine aminotransferase (ALT), high-density lipoprotein cholesterol (HDL), and total cholesterol (TC). The multilayer perceptron (MLP) and extreme gradient boosting (XGB) models showed optimal performance for sub-therapeutic (AUROC = 0.646, Brier = 0.190) and supra-therapeutic (AUROC = 0.825, Brier = 0.143) risk prediction, respectively, with consistent results in temporal validation (AUROC: 0.678, Brier = 0.190 and AUROC: 0.767, Brier = 0.190). CONCLUSION: This study is the first to use machine learning models to predict the risk of sub- or supra-therapeutic sirolimus concentrations in vascular anomalies children. By enabling personalized exposure risk prediction, the dosing accuracy of sirolimus for the treatment of children with vascular anomalies can be optimized, thereby enhancing effectiveness and safety. CI - (c) 2026 Hu et al. FAU - Hu, Ya-Hui AU - Hu YH AD - Pharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Li, Wan-Xia AU - Li WX AD - School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing, 210009, China. AD - Department of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China. FAU - Fan, Lin AU - Fan L AD - Pharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Zhou, Zhou AU - Zhou Z AD - Department of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China. FAU - Guo, Hong-Li AU - Guo HL AUID- ORCID: 0000-0002-6660-8145 AD - Pharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Chen, Feng AU - Chen F AD - Pharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Zou, Jian-Jun AU - Zou JJ AUID- ORCID: 0000-0003-0886-3153 AD - Department of Pharmacy, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China. FAU - Ji, Yi AU - Ji Y AD - Department of Burns and Plastic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Xu, Jin AU - Xu J AD - Pharmaceutical Sciences Research Center, Department of Pharmacy, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. FAU - Shen, Wei-Min AU - Shen WM AD - Department of Burns and Plastic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, 210008, China. LA - eng PT - Journal Article DEP - 20260108 PL - New Zealand TA - Drug Des Devel Ther JT - Drug design, development and therapy JID - 101475745 RN - W36ZG6FT64 (Sirolimus) SB - IM MH - Humans MH - *Sirolimus/administration & dosage/blood/therapeutic use MH - *Machine Learning MH - Risk Factors MH - Retrospective Studies MH - Female MH - Child MH - Male MH - Child, Preschool MH - Predictive Learning Models MH - Drug Monitoring MH - Infant MH - *Vascular Malformations/drug therapy MH - Prediction Algorithms PMC - PMC13000750 OTO - NOTNLM OT - children OT - concentration risk prediction OT - machine learning OT - sirolimus OT - vascular anomalies COIS- The authors declare no conflicts of interest in this work. EDAT- 2026/03/23 06:31 MHDA- 2026/03/23 13:03 PMCR- 2026/01/08 CRDT- 2026/03/23 05:52 PHST- 2025/08/27 00:00 [received] PHST- 2025/12/12 00:00 [accepted] PHST- 2026/03/23 13:03 [medline] PHST- 2026/03/23 06:31 [pubmed] PHST- 2026/03/23 05:52 [entrez] PHST- 2026/01/08 00:00 [pmc-release] AID - 563637 [pii] AID - 10.2147/DDDT.S563637 [doi] PST - epublish SO - Drug Des Devel Ther. 2026 Jan 8;20:563637. doi: 10.2147/DDDT.S563637. eCollection 2026. PMID- 41867934 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260323 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Relationships among children's muscular strength, neuromuscular control, and resilience. PG - 1743647 LID - 10.3389/fped.2026.1743647 [doi] LID - 1743647 AB - INTRODUCTION: Children who participate in recess interventions demonstrate increased upper- and lower-body muscular strength (MusS), neuromuscular control (NC), and resilience. However, to measure the effectiveness of recess interventions, identifying the relationship between physical and psychological assessments is necessary for reliability and consistency. Therefore, this study explores the relationships and variable predictions among MusS, NC, and resilience assessments in fourth- and fifth-grade children at two time points during one school year. METHODS: A total of 164 fourth- and fifth-grade children participated in MusS (standing broad jump, push-ups, single-leg three-hop, and average grip strength), NC (side-step), and resilience (Child and Youth Resilience Measure-Revised) assessments. A single intraclass correlation coefficient was calculated in September (Time 1) and January (Time 2) to evaluate the reliability of each assessment. Next, Pearson product correlations and multiple linear regression analyses were conducted to assess outcomes. RESULTS: Times 1 and 2 had positive, moderate, and significant correlations among the following MusS assessments: standing broad jump and average single-leg three-hop, standing broad jump and push-up, and average single-leg three-hop and push-up (p < 0.01). NC and resilience had no meaningful correlations with the other assessments. Regression analyses further revealed that push-up performance was a significant predictor of standing broad jump performance at Times 1 and 2 (p < 0.001). CONCLUSIONS: MusS assessments were practical, reliable, time-efficient, and low cost for this age group. Therefore, these elements should be taken into consideration to measure the effectiveness of recess or physical activity interventions. In addition, the results revealed correlations between upper- and lower-body MusS assessments. The relationship between the standing broad jump and push-ups highlights the interconnective nature of the upper and lower MusS. This raises the question of why resilience and NC were not related to each other or to MusS assessments. Given the exploratory nature and short duration of this study, further research is needed to validate these findings and to determine whether there are more effective NC and resilience assessments to use with this age group. CI - (c) 2026 Wagner, Esposito, Braun-Trocchio, von Borck and Rhea. FAU - Wagner, Lauren M AU - Wagner LM AD - Department of Kinesiology, Texas Christian University, Fort Worth, TX, United States. FAU - Esposito, Phil AU - Esposito P AD - Department of Kinesiology, Texas Christian University, Fort Worth, TX, United States. FAU - Braun-Trocchio, Robyn AU - Braun-Trocchio R AD - Department of Kinesiology, Texas Christian University, Fort Worth, TX, United States. FAU - von Borck, Hailey G AU - von Borck HG AD - Department of Kinesiology, Texas Christian University, Fort Worth, TX, United States. FAU - Rhea, Deborah J AU - Rhea DJ AD - Department of Kinesiology, Texas Christian University, Fort Worth, TX, United States. LA - eng PT - Journal Article DEP - 20260306 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC13002809 OTO - NOTNLM OT - assessment OT - child performance OT - fitness OT - muscular strength OT - neuromuscular control OT - resilience COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/23 06:32 MHDA- 2026/03/23 06:33 PMCR- 2026/03/06 CRDT- 2026/03/23 05:50 PHST- 2025/11/11 00:00 [received] PHST- 2026/02/05 00:00 [revised] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/03/23 06:33 [medline] PHST- 2026/03/23 06:32 [pubmed] PHST- 2026/03/23 05:50 [entrez] PHST- 2026/03/06 00:00 [pmc-release] AID - 10.3389/fped.2026.1743647 [doi] PST - epublish SO - Front Pediatr. 2026 Mar 6;14:1743647. doi: 10.3389/fped.2026.1743647. eCollection 2026. PMID- 41865309 OWN - NLM STAT- MEDLINE DCOM- 20260618 LR - 20260818 IS - 1552-5732 (Electronic) IS - 0890-3344 (Linking) VI - 42 IP - 2 DP - 2026 May TI - Breastfeeding Measurement Instruments: A COSMIN Review and Recommendation. PG - 324-335 LID - 10.1177/08903344261420017 [doi] AB - AIM: To comprehensively assess the quality of current breastfeeding measurement instruments and to recommend instruments. BACKGROUND: The field of breastfeeding assessment is characterized by a diverse array of measurement tools, yet their application is complicated by heterogeneity in psychometric quality and inconsistent findings. Previous systematic reviews employing the COSMIN (CONsensus-based Standards for the selection of health Measurement INstruments) framework have been limited in scope, highlighting the need for a contemporary and comprehensive evaluation to guide instrument selection. METHODS: Following COSMIN guidelines, we systematically searched 10 Chinese and English databases from inception to September 30, 2024. Two reviewers independently conducted study screening, data extraction, and methodological quality assessment. Evidence was synthesized and recommendations were formulated based on predefined criteria. RESULTS: Analysis of 54 studies evaluating 24 instruments revealed substantial evidence gaps in key measurement properties. Reliability data were missing for 52% of instruments, while cross-cultural validity/measurement invariance, criterion validity, and responsiveness were assessed in fewer than 30% of cases. No instrument had established values for minimal important change or smallest detectable change. Seven instruments measuring self-efficacy, support needs, and breastfeeding behavior prediction received Grade A recommendations. DISCUSSION: The review offers a validated evidence base to guide instrument selection. Future research should prioritize closing the identified evidence gaps, particularly establishing reliability and clinically meaningful change parameters for all recommended tools. CONCLUSIONS: This review provides an evidence base for instrument selection while identifying critical gaps in measurement property evidence, particularly in reliability and clinically interpretable parameters, directing future validation research priorities. FAU - Liu, Bingjie AU - Liu B AUID- ORCID: 0009-0002-1586-3979 AD - Beijing University of Chinese Medicine, China. FAU - Zhou, Fen AU - Zhou F AUID- ORCID: 0000-0002-4384-4655 AD - Beijing University of Chinese Medicine, China. AD - Beijing University of Chinese Medicine Collaborating Center of Joanna Briggs Institute, China. FAU - Lv, Yunpeng AU - Lv Y AUID- ORCID: 0000-0003-3095-9549 AD - Qingdao Municipal Hospital, Shandong, China. FAU - Lin, Keke AU - Lin K AUID- ORCID: 0000-0003-1755-0415 AD - Beijing University of Chinese Medicine, China. FAU - Wang, Yuxi AU - Wang Y AUID- ORCID: 0009-0005-7070-4964 AD - Beijing University of Chinese Medicine, China. FAU - Xu, Botan AU - Xu B AUID- ORCID: 0009-0000-0594-9424 AD - Beijing University of Chinese Medicine, China. FAU - Yuan, Ting AU - Yuan T AUID- ORCID: 0000-0003-3085-1554 AD - Xi'an Honghui Hospital, Shaanxi, China. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260322 PL - United States TA - J Hum Lact JT - Journal of human lactation : official journal of International Lactation Consultant Association JID - 8709498 SB - IM MH - Humans MH - *Breast Feeding/psychology MH - *Psychometrics/instrumentation/methods/standards MH - Female MH - Reproducibility of Results MH - Evidence Gaps MH - Surveys and Questionnaires OTO - NOTNLM OT - anatomy OT - breastfeeding OT - breastfeeding assessment OT - breastfeeding assessment instruments OT - breastfeeding attrition prediction tool OT - infant/neonate OT - maternal COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/03/22 12:47 MHDA- 2026/06/18 12:34 CRDT- 2026/03/22 10:53 PHST- 2026/06/18 12:34 [medline] PHST- 2026/03/22 12:47 [pubmed] PHST- 2026/03/22 10:53 [entrez] AID - 10.1177/08903344261420017 [doi] PST - ppublish SO - J Hum Lact. 2026 May;42(2):324-335. doi: 10.1177/08903344261420017. Epub 2026 Mar 22. PMID- 41865308 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260818 IS - 1552-5732 (Electronic) IS - 0890-3344 (Linking) VI - 42 IP - 1 DP - 2026 Feb TI - Measuring Low Milk Supply: Methods and Implications for Lactation Research and Clinical Practice. PG - 126-134 LID - 10.1177/08903344261426744 [doi] AB - BACKGROUND: Low milk supply is a common problem in lactation, yet it is difficult to study and manage due to multifactorial causes and inconsistent measurement across research and clinical practice. OBJECTIVE: To synthesize current subjective and objective approaches to assessing low milk supply, including scales and survey items, infant weight trajectories and test-weight procedures, milk expression protocols, biomarkers, and device-based metrics. For each method, we appraise validity, feasibility, and potential harms. KEY POINTS: In both research and clinical settings, low milk supply is measured inconsistently and imprecisely. Tools available to assess maternal perception of low milk supply and quantify infant milk intake and production all have limitations. CONCLUSION: Combining self-report and objective measurements and selecting measurement tools specific to the outcome of interest can help with accurate identification and management of low milk supply. FAU - Kivlighan, Katie T AU - Kivlighan KT AUID- ORCID: 0000-0001-5531-1330 AD - College of Nursing, University of New Mexico Health Sciences Center, Albuquerque, NM, USA. FAU - Demirci, Jill R AU - Demirci JR AUID- ORCID: 0000-0002-4802-7849 AD - University of Pittsburgh School of Nursing, Pittsburgh, PA, USA. LA - eng PT - Journal Article PT - Review DEP - 20260322 PL - United States TA - J Hum Lact JT - Journal of human lactation : official journal of International Lactation Consultant Association JID - 8709498 SB - IM MH - Humans MH - Female MH - *Lactation/physiology MH - *Milk, Human/metabolism MH - Breast Feeding/methods MH - *Lactation Disorders/diagnosis OTO - NOTNLM OT - breastfeeding OT - hypogalactia OT - hypolactation OT - insufficient milk supply OT - lactation insufficiency OT - low milk supply COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/03/22 12:47 MHDA- 2026/03/26 07:08 CRDT- 2026/03/22 10:52 PHST- 2026/03/26 07:08 [medline] PHST- 2026/03/22 12:47 [pubmed] PHST- 2026/03/22 10:52 [entrez] AID - 10.1177/08903344261426744 [doi] PST - ppublish SO - J Hum Lact. 2026 Feb;42(1):126-134. doi: 10.1177/08903344261426744. Epub 2026 Mar 22. PMID- 41865274 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260924 IS - 1465-3664 (Electronic) IS - 0142-6338 (Linking) VI - 72 IP - 2 DP - 2026 Feb 9 TI - Effect of structured breastfeeding early intervention package for babies born at less than 34 weeks gestation on exclusive breastfeeding at 6 months-a quasi-experimental study. LID - fmag007 [pii] LID - 10.1093/tropej/fmag007 [doi] AB - Human milk is the optimal source of nutrition for preterm infants, significantly reducing neonatal morbidities and enhancing neurodevelopmental outcomes. However, preterm neonates face challenges in direct breastfeeding due to immaturity, maternal-infant separation, and inadequate milk production. The aim of this study is to compare the impact of a structured early intervention package on exclusive breastfeeding rate and compare that to a control group that had no structured early intervention package regarding exclusive breastfeeding at 6 months of chronological age in neonates born at less than 34 weeks. Eligible mother-infant dyads were divided into the control and intervention groups. While both the groups received breastfeeding counseling, the control group received routine counseling as per WHO guidelines during antenatal visits, hospital stay, and follow-up immunization visits. In contrast, the intervention group received structured, frequent counseling using specially developed education materials, including intrapartum counseling in the pre-labor area, early initiation of expression facilitated by designated personnel, and scheduled postnatal sessions. Breast milk output was measured at days 3, 7, and 14 or discharge. Exclusive breastfeeding rates were assessed at 6 months. Among 90 enrolled dyads, the exclusive breastfeeding rate at 6 months was significantly higher in the intervention group (75.0%) compared to the control group (47.3%) (P value = .015). Breast milk output on day 3 was also significantly higher in the intervention group (P value = .008). The findings indicate that integrating structured lactation support into neonatal care can improve breastfeeding outcomes, and larger studies are needed to validate these results. CI - (c) The Author(s) 2026. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Ahmed, Syed Moiz AU - Ahmed SM AD - ABVIMS and Dr RML Hospital, New Delhi 110001, India. FAU - Maria, Arti AU - Maria A AD - ABVIMS and Dr RML Hospital, New Delhi 110001, India. FAU - Mishra, Divya AU - Mishra D AD - Graphic Era Deemed to be University, Dehradun, Uttarakhand 248002, India. FAU - Shubham, Shantanu AU - Shubham S AUID- ORCID: 0000-0002-5278-3655 AD - Graphic Era Deemed to be University, Dehradun, Uttarakhand 248002, India. FAU - Dubey, Bhawna AU - Dubey B AD - ABVIMS and Dr RML Hospital, New Delhi 110001, India. LA - eng PT - Journal Article PL - England TA - J Trop Pediatr JT - Journal of tropical pediatrics JID - 8010948 SB - IM MH - Humans MH - *Breast Feeding/statistics & numerical data MH - Female MH - Infant, Newborn MH - Infant MH - *Infant, Premature MH - *Counseling/methods MH - Adult MH - *Mothers/education/psychology MH - Gestational Age MH - *Milk, Human MH - Male MH - Pregnancy MH - Follow-Up Studies EDAT- 2026/03/22 12:47 MHDA- 2026/03/22 12:48 CRDT- 2026/03/22 08:23 PHST- 2026/03/22 12:48 [medline] PHST- 2026/03/22 12:47 [pubmed] PHST- 2026/03/22 08:23 [entrez] AID - 8537057 [pii] AID - 10.1093/tropej/fmag007 [doi] PST - ppublish SO - J Trop Pediatr. 2026 Feb 9;72(2):fmag007. doi: 10.1093/tropej/fmag007. PMID- 41865162 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 21 TI - VR-guided deep breathing during needle procedures in children. LID - 10.1038/s41598-026-44390-y [doi] LID - 14375 AB - Virtual reality-based treatment has been found to be effective at reducing stress and fear in children during procedures involving needles, but its effects on the autonomic nervous system and heart rate variability remain uncertain. This feasibility study compared a virtual reality-mediated deep breathing exercise with treatment as usual in managing the stress and fear of children during a venipuncture. We included 45 children who underwent a needle procedure as part of their routine treatment. The study patients performed 6 min of deep breathing training in a virtual natural environment during the needle procedure. The stress response in the autonomic nervous system was determined by heart rate variability measurements. The median respiratory rate was significantly lower during the intervention in the deep breathing training group (median 14 [Q1-12, Q3-16.5]) than in the control group (20 [18, 20.88]), (p < .001), confirming good compliance with exercise. In a 6-min heart rate variability measurement, mean high frequency in normalised unit (HFnu, 0.15-0.4 Hz) indicates a significantly greater level of activation in the parasympathetic nervous system during exercise (mean 61.57 [SD 16.29]) than in the control (40.46 [16.10]), (p < .001). Virtual reality-mediated guided deep breathing is a feasible nonpharmaceutical treatment option for stress and fear relief when treating child patients undergoing a needle procedure. CI - (c) 2026. The Author(s). FAU - Karppa, Elina AU - Karppa E AD - TamCAM Research Center, Faculty of Medicine and Health Technology, Tampere University, Elamanaukio 2, 33521, Tampere, Finland. elina.karppa@tuni.fi. AD - Department of Pediatrics, Tampere University Hospital, Central Hospital, Tampere, Finland. elina.karppa@tuni.fi. AD - Finnish Institute of High Performance Sport KIHU, Jyvaskyla, Finland. elina.karppa@tuni.fi. FAU - Puura, Kaija AU - Puura K AD - TamCAM Research Center, Faculty of Medicine and Health Technology, Tampere University, Elamanaukio 2, 33521, Tampere, Finland. AD - Department of Child Psychiatry, Tampere University Hospital, Central Hospital, Tampere, Finland. FAU - Jyska, Ilmari AU - Jyska I AD - Pervasive Interaction Research Group (PIRG), Tampere Unit for Computer-Human Interaction (TAUCHI), Faculty of Information Technology and Communication Sciences (ITC), Tampere University, Tampere, Finland. FAU - Viik, Jari AU - Viik J AD - Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. FAU - Pohjankoski, Heini AU - Pohjankoski H AD - Department of Pediatrics, Paijat-Hame Central Hospital, Lahti, Finland. FAU - Turunen, Markku AU - Turunen M AD - Pervasive Interaction Research Group (PIRG), Tampere Unit for Computer-Human Interaction (TAUCHI), Faculty of Information Technology and Communication Sciences (ITC), Tampere University, Tampere, Finland. AD - Tampere Accessibility Unit (TACCU), Faculty of Information Technology and Communication Sciences (ITC), Tampere University, Tampere, Finland. FAU - Palmu, Sauli AU - Palmu S AD - TamCAM Research Center, Faculty of Medicine and Health Technology, Tampere University, Elamanaukio 2, 33521, Tampere, Finland. AD - Department of Pediatrics, Tampere University Hospital, Central Hospital, Tampere, Finland. LA - eng PT - Journal Article DEP - 20260321 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Heart Rate/physiology MH - Child MH - Male MH - *Virtual Reality MH - Needles MH - *Breathing Exercises/methods MH - Feasibility Studies MH - *Respiration MH - Autonomic Nervous System/physiology MH - Adolescent MH - Fear/psychology MH - *Stress, Psychological MH - Respiratory Rate PMC - PMC13144402 OTO - NOTNLM OT - Autonomic nervous system OT - Child patient OT - Deep breathing OT - Fear of needles OT - Heart rate variability OT - Virtual reality COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: The study protocol was approved by the local ethics committee (Ethics Committee of the Tampere Region, Finland; R21068L) in accordance with the Declaration of Helsinki and by the national authority supervising clinical device trials (The Finnish Medicines Agency, FIMEA). Consent to participate: Written informed consent to participate in the study was obtained from both the patient and the caregiver. Consent for publication: Not applicable. EDAT- 2026/03/22 07:35 MHDA- 2026/05/06 00:33 PMCR- 2026/03/21 CRDT- 2026/03/22 00:22 PHST- 2025/11/18 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/05/06 00:33 [medline] PHST- 2026/03/22 07:35 [pubmed] PHST- 2026/03/22 00:22 [entrez] PHST- 2026/03/21 00:00 [pmc-release] AID - 10.1038/s41598-026-44390-y [pii] AID - 44390 [pii] AID - 10.1038/s41598-026-44390-y [doi] PST - epublish SO - Sci Rep. 2026 Mar 21;16(1):14375. doi: 10.1038/s41598-026-44390-y. PMID- 41864152 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260730 IS - 1872-8243 (Electronic) IS - 1386-5056 (Linking) VI - 214 DP - 2026 Jul 1 TI - Research using smartwatches for the measurement of physical activity, sedentary behavior, and sleep: A scoping review. PG - 106370 LID - S1386-5056(26)00110-3 [pii] LID - 10.1016/j.ijmedinf.2026.106370 [doi] AB - OBJECTIVE: The objective of this scoping review is to map the evidence on using smartwatches to objectively measure physical activity (PA), sedentary behavior (SB), and sleep in children, adolescents, adults, and older adults. METHODS: This review followed the Joanna Briggs Institute (JBI) guidelines for scoping reviews, following a previously published protocol. The searches were conducted in January 2022 on Medline, Scopus, Web of Science, IEEE Xplore Digital Library, Scielo, LILACS, Health Technology Assessment Database, Cochrane clinical trials, and clinical trials. The screening was performed independently by two authors. A narrative synthesis was used. RESULTS: After the electronic search, 5,925 records were identified and 2,008 duplicates removed. Screening of 3,917 titles and abstracts resulted in 491 full-text articles assessed for eligibility. A total of 427 studies were excluded for not meeting inclusion criteria, with one study added after author contact. Thus, 64 of these studies were included. Sample sizes ranged widely from 4 to 6,454 participants, with most studies (80.9%) including 100 or fewer participants. Most studies were conducted in the United States (46.9%), followed by China (9.4%). A total of 18 different smartwatch brands were identified, with Apple(R) being the most investigated (46.9%), followed by Samsung(R) (15.6), Fitbit(R) (14.1%), Motorola(R) (10.9%), Polar(R) (10.9%), Garmin(R) (9.4%), Asus(R) (3.1%), and others (1.6% each. Smartwatches were primarily used to validate measurements of PA, SB, and/or sleep parameters, followed by their use in assessing these variables as exposures or outcomes, testing feasibility, supporting self-monitoring, and other purposes. The most frequently measured variables were steps, total sleep time, and SB. CONCLUSION: This review can help studies, interventions, and health professionals that aim to use this technology as a measurement instrument, as well as help end users who use it on a daily basis. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - da Silva, Jose Francisco AU - da Silva JF AD - Postgraduate Program in Physical Education, University of Pernambuco, Recife, Pernambuco, Brazil; Department of Physical Education, Faculdade Pernambucana de Saude, Recife, Pernambuco, Brazil. FAU - Germano-Soares, Antonio Henrique AU - Germano-Soares AH AD - Department of Physical Education, Faculdade Pernambucana de Saude, Recife, Pernambuco, Brazil; Health Research and Innovation Science Centre, Faculty of Health Sciences, Klaipeda University, Klaipeda, Lithuania. FAU - de Oliveira, Tuillamys Virginio AU - de Oliveira TV AD - Department of Physical Education, Faculdade Pernambucana de Saude, Recife, Pernambuco, Brazil. FAU - Barbosa Silva, Luis Carlos AU - Barbosa Silva LC AD - Postgraduate Program in Physical Education, University of Pernambuco, Recife, Pernambuco, Brazil. FAU - Barbosa Filho, Valter Cordeiro AU - Barbosa Filho VC AD - Program on Collective Health, Ceara State University, Fortaleza, Ceara, Brazil. FAU - de Aguiar Silva, Thiago Coelho AU - de Aguiar Silva TC AD - Department of Physical Education, University of Pernambuco, Recife, Pernambuco, Brazil. FAU - Tassitano, Rafael Miranda AU - Tassitano RM AD - Department of Health and kinesiology, University of Illinois Urbana-Champaign. Illinois, United States. Electronic address: rafaelmt@illinois.edu. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260317 PL - Ireland TA - Int J Med Inform JT - International journal of medical informatics JID - 9711057 SB - IM MH - Humans MH - *Sedentary Behavior MH - *Sleep/physiology MH - *Exercise MH - Digital Health MH - Child MH - Adolescent MH - Adult OTO - NOTNLM OT - Mhealth OT - Movement behaviors OT - Smartwatch OT - Wearable electronic devices OT - Wristwatch COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/22 06:06 MHDA- 2026/04/25 00:34 CRDT- 2026/03/21 19:17 PHST- 2024/08/05 00:00 [received] PHST- 2026/02/25 00:00 [revised] PHST- 2026/03/01 00:00 [accepted] PHST- 2026/04/25 00:34 [medline] PHST- 2026/03/22 06:06 [pubmed] PHST- 2026/03/21 19:17 [entrez] AID - S1386-5056(26)00110-3 [pii] AID - 10.1016/j.ijmedinf.2026.106370 [doi] PST - ppublish SO - Int J Med Inform. 2026 Jul 1;214:106370. doi: 10.1016/j.ijmedinf.2026.106370. Epub 2026 Mar 17. PMID- 41864088 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260810 IS - 1532-1983 (Electronic) IS - 0261-5614 (Linking) VI - 60 DP - 2026 May TI - Muscle atrophy associated with glucagon-like Peptide-1 receptor agonists: A population-based observational study. PG - 106620 LID - S0261-5614(26)00047-6 [pii] LID - 10.1016/j.clnu.2026.106620 [doi] AB - Background and AimEmerging evidence suggests that weight loss associated with glucagon-like peptide-1 receptor agonists (GLP-1 RAs) may be in part attributable to changes in lean mass, which has potential clinical implications. This study evaluates the disproportionate reporting of muscle atrophy in association with GLP-1 RA therapy using real-world global data.. MethodsWe analyzed reports of muscle atrophy submitted to the FDA Adverse Event Reporting System (FAERS) database from October 2003 to March 2024 using the validated pharmacovigilance tool OpenVigil 2.1. Disproportionality was assessed using reporting odds ratios (RORs) with 95 % confidence intervals (CIs), the standard metric for pharmacovigilance signal detection worldwide. To contextualize associations, disproportionality estimates were calculated using niacin, simvastatin, and the complete FAERS database (all other drugs) as comparators. ResultsA total of 142 cases of muscle atrophy were identified with GLP-1 RA therapy, the majority occurring in adults aged 18-64 years (43 % female, 57 % male). Disproportionality analysis showed pharmacovigilance signals for semaglutide (ROR = 2.39, 95 % CI = 1.63-3.52) and tirzepatide (ROR = 1.69, 95 % CI = 1.14-2.50), indicating increased reporting of muscle atrophy relative to all other drugs in FAERS. In contrast, exenatide (ROR = 0.26, 95 % CI = 0.12-0.55) and liraglutide (ROR = 0.27, 95 % CI = 0.09-0.83) were associated with significantly lower reporting odds. All significant signals satisfied thresholds of p < 0.05 and IC(025) > 0.. ConclusionsCertain GLP-1 receptor agonists demonstrate a pharmacovigilance signal of disproportionate reporting of muscle atrophy. These findings should be interpreted as signal detection rather than evidence of causality and highlight the need for future studies incorporating objective measures of muscle mass and function.. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Kwan, Angela T H AU - Kwan ATH AD - Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address: angela.kwan@mail.utoronto.ca. FAU - Lakhani, Moiz AU - Lakhani M AD - Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Electronic address: mlakh088@uottawa.ca. FAU - McIntyre, Roger S AU - McIntyre RS AD - Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada; Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada. Electronic address: roger.mcintyre@bcdf.org. LA - eng PT - Journal Article PT - Observational Study DEP - 20260304 PL - England TA - Clin Nutr JT - Clinical nutrition (Edinburgh, Scotland) JID - 8309603 RN - 9P1872D4OL (Exenatide) RN - 0 (Glucagon-Like Peptide-1 Receptor) RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) RN - 62340-29-8 (Glucagon-Like Peptides) RN - 0 (Hypoglycemic Agents) RN - 839I73S42A (Liraglutide) RN - 53AXN4NNHX (Semaglutide) RN - OYN3CCI6QE (Tirzepatide) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Adverse Drug Reaction Reporting Systems/statistics & numerical data MH - Exenatide/adverse effects MH - Glucagon-Like Peptide-1 Receptor MH - *Glucagon-Like Peptide-1 Receptor Agonists MH - Glucagon-Like Peptides/adverse effects MH - *Hypoglycemic Agents/adverse effects MH - Liraglutide/adverse effects MH - *Muscular Atrophy/chemically induced/epidemiology MH - Pharmacovigilance MH - Semaglutide MH - Tirzepatide MH - United States OTO - NOTNLM OT - FAERS OT - Glucagon-like Peptide-1 receptor agonists (GLP-1 RAs) OT - Muscle atrophy OT - Muscle wasting OT - Semaglutide OT - Tirzepatide COIS- Declaration of interests Dr. Roger S. McIntyre has received research grant support from CIHR, GACD, the National Natural Science Foundation of China (NSFC), and the Milken Institute. He has received speaker/consultation fees from Lundbeck, Janssen, Johnson & Johnson, Alkermes, Neumora Therapeutics, Boehringer Ingelheim, Bristol Myers Squibb, Sage, Mitsubishi Tanabe, Purdue, Pfizer, Otsuka, Takeda, MindMed, Neurocrine, Neurawell, Supernus, Bausch Health, Axsome, Novo Nordisk, Kris, Sanofi, Eisai, Intra-Cellular, NewBridge Pharmaceuticals, Viatris, AbbVie, and Atai Life Sciences. Angela T.H. Kwan and Moiz Lakhani declare no proprietary interests or conflicts of interest related to this submission. EDAT- 2026/03/22 06:06 MHDA- 2026/04/21 17:56 CRDT- 2026/03/21 19:12 PHST- 2025/12/10 00:00 [received] PHST- 2026/01/21 00:00 [revised] PHST- 2026/02/27 00:00 [accepted] PHST- 2026/04/21 17:56 [medline] PHST- 2026/03/22 06:06 [pubmed] PHST- 2026/03/21 19:12 [entrez] AID - S0261-5614(26)00047-6 [pii] AID - 10.1016/j.clnu.2026.106620 [doi] PST - ppublish SO - Clin Nutr. 2026 May;60:106620. doi: 10.1016/j.clnu.2026.106620. Epub 2026 Mar 4. PMID- 41863868 OWN - NLM STAT- MEDLINE DCOM- 20260717 LR - 20260806 IS - 1873-5487 (Electronic) IS - 0188-4409 (Linking) VI - 57 IP - 5 DP - 2026 Jul TI - Development and Validation of a Dietary Adherence Index for Mexican Women Based on the Mexican Dietary Guidelines 2023. PG - 103411 LID - S0188-4409(26)00034-2 [pii] LID - 10.1016/j.arcmed.2026.103411 [doi] AB - BACKGROUND: Women of childbearing age have the highest prevalence of malnutrition in Mexico. The 2023 Mexican Healthy and Sustainable Dietary Guidelines (GASS) aim to address this issue through health and sustainability recommendations. However, the absence of tools that assess adherence limits monitoring and policy application. OBJECTIVE: To develop and validate the GASSMx-2023 tool (GASSMx-2023 index) and its associated score to measure adherence to the GASS among Mexican women aged 20-49 years. METHODS: A methodological study was conducted to develop a tool based on GASS food groups, subgroups, and recommended intake levels. Validation was conducted using a national subsample of women from the 2020 National Health and Nutrition Survey (ENSANUT) and involved three phases: i) content validity by expert judgment, ii) internal consistency, and iii) construct validity. RESULTS: The developed tool includes nine components and 15 subcomponents; the maximum score was 95 points, based on adequacy, moderation, and optimal intake metrics. Content validity was acceptable (coefficient = 0.8). Vegetables, fruits, whole grains, eggs, and beef accounted for 71% of the score variability. The index showed independence from energy intake and good discriminatory power, distinguishing women in extreme quartiles. It also detected differences between groups based on diet-related individual characteristics, in accordance with the GASS framework. CONCLUSION: The GASSMx-2023 index is a novel tool for assessing adherence to the GASS and distinguishing dietary quality among Mexican women aged 20-49. Its ability to identify key consumption patterns and support nutrition policy makes it a valuable instrument for improving dietary health in Mexico. CI - Copyright (c) 2026 Instituto Mexicano del Seguro Social (IMSS). Published by Elsevier Inc. All rights reserved. FAU - Chavarria-Ornelas, Paulina AU - Chavarria-Ornelas P AD - Nutrition and Health Research Center, National Institute of Public Health, Cuernavaca, Mor., Mexico. FAU - Rodriguez-Ramirez, Sonia AU - Rodriguez-Ramirez S AD - Nutrition and Health Research Center, National Institute of Public Health, Cuernavaca, Mor., Mexico. Electronic address: scrodrig@insp.mx. FAU - Trejo-Valdivia, Belem AU - Trejo-Valdivia B AD - Nutrition and Health Research Center, National Institute of Public Health, Cuernavaca, Mor., Mexico. FAU - Shamah-Levy, Teresa AU - Shamah-Levy T AD - Evaluation and Survey Research Center, National Institute of Public Health, Cuernavaca, Mor., Mexico. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20260320 PL - United States TA - Arch Med Res JT - Archives of medical research JID - 9312706 SB - IM MH - Humans MH - Female MH - Mexico/epidemiology MH - Adult MH - *Nutrition Policy MH - Middle Aged MH - Nutrition Surveys MH - Young Adult MH - *Diet MH - *Patient Compliance/statistics & numerical data MH - Energy Intake OTO - NOTNLM OT - Diet quality OT - Dietary guidelines Adherence OT - Dietary index OT - Reproductive age women COIS- Conflicts-of-Interest The authors declare no conflicts of interest. EDAT- 2026/03/22 06:07 MHDA- 2026/07/17 23:02 CRDT- 2026/03/21 18:59 PHST- 2025/08/14 00:00 [received] PHST- 2026/01/23 00:00 [revised] PHST- 2026/03/06 00:00 [accepted] PHST- 2026/07/17 23:02 [medline] PHST- 2026/03/22 06:07 [pubmed] PHST- 2026/03/21 18:59 [entrez] AID - S0188-4409(26)00034-2 [pii] AID - 10.1016/j.arcmed.2026.103411 [doi] PST - ppublish SO - Arch Med Res. 2026 Jul;57(5):103411. doi: 10.1016/j.arcmed.2026.103411. Epub 2026 Mar 20. PMID- 41863066 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 1099-0801 (Electronic) IS - 0269-3879 (Linking) VI - 40 IP - 5 DP - 2026 May TI - Residue Behaviors and Dietary Risks of Aryloxyphenoxy Propionate Herbicides in Rice Ecosystem by UPLC-MS/MS. PG - e70431 LID - 10.1002/bmc.70431 [doi] AB - Currently, aryloxyphenoxy propionate (AOPP) herbicides, famous second only to glyphosate, have been widely used worldwide, such as cyhalofop-butyl, metamifop in rice ecosystem. In this work, field trials and QuEChERS liquid chromatography tandem mass spectrometry (LC-MS/MS) gave comprehensive residues in rice ecosystem for cyhalofop-butyl, metamifop, and their metabolites. Field trials involved 12 rice varieties and 12 sites with different climates and conditions. The determination method was reliable with average recoveries of seven analytes in brown rice, husk, and straw between 90.2% and 110.0%, with RSDs /= 0.9. Treatment outcomes, including objective response rate (ORR), progression-free survival (PFS), overall survival (OS), and time to partial response (TtPR), were compared between patients with and without hyperintense nodules. RESULTS: Of the 152 patients, 82 received immunotherapy as the first-line and 70 as a later-line therapy. Hyperintense nodules were identified in 57 (37.5%) patients. The hyperintense group showed a higher ORR (36.8% vs. 22.1%) and comparable PFS (8.9 vs. 7.9 months) and OS (16.7 vs. 23.9 months), though not statistically significant. The TtPR was significantly shorter in the hyperintense group (median 26.0 months vs. not reached, p = 0.033), although mainly influenced by prior systemic therapy. Overall, hyperintense lesions were not associated with reduced efficacy and tended to show more favorable responses. CONCLUSION: This prospective multicenter study demonstrates that hepatobiliary hyperintensity on Gd-EOB-DTPA-enhanced MRI-an imaging surrogate of Wnt/beta-catenin activation-does not indicate resistance to atezolizumab plus bevacizumab. These findings support the use of combination immunotherapy in molecularly "immune-cold" HCC. CI - (c) 2026 The Author(s). Hepatology Research published by John Wiley & Sons Australia, Ltd on behalf of Japan Society of Hepatology. FAU - Aoki, Tomoko AU - Aoki T AUID- ORCID: 0000-0002-9950-4553 AD - Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan. AD - Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan. FAU - Kudo, Masatoshi AU - Kudo M AUID- ORCID: 0000-0002-4102-3474 AD - Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan. FAU - Ueshima, Kazuomi AU - Ueshima K AUID- ORCID: 0000-0002-7577-5789 AD - Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan. FAU - Tsurusaki, Masakatsu AU - Tsurusaki M AUID- ORCID: 0000-0001-9894-4912 AD - Department of Radiology, Kansai Medical University Medical Center, Osaka, Japan. FAU - Sofue, Keitaro AU - Sofue K AD - Department of Radiology, Kobe University Graduate School of Medicine, Kobe, Japan. FAU - Yano, Yoshihiko AU - Yano Y AUID- ORCID: 0000-0002-5177-7480 AD - Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan. FAU - Toyoda, Hidenori AU - Toyoda H AUID- ORCID: 0000-0002-1652-6168 AD - Department of Gastroenterology and Hepatology, Ogaki Municipal Hospital, Ogaki, Japan. FAU - Hiraoka, Atsushi AU - Hiraoka A AD - Gastroenterology Center, Ehime Prefectural Central Hospital, Matsuyama, Japan. FAU - Hatanaka, Takeshi AU - Hatanaka T AUID- ORCID: 0000-0003-3656-285X AD - Department of Gastroenterology, Gunma Saiseikai Maebashi Hospital, Maebashi, Japan. FAU - Naganuma, Atsushi AU - Naganuma A AUID- ORCID: 0000-0003-0663-0102 AD - Department of Gastroenterology, NHO Takasaki General Medical Center, Takasaki, Japan. FAU - Kakizaki, Satoru AU - Kakizaki S AUID- ORCID: 0000-0003-0224-7093 AD - Department of Clinical Research, NHO Takasaki General Medical Center, Takasaki, Japan. FAU - Itokawa, Norio AU - Itokawa N AD - Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan. FAU - Atsukawa, Masanori AU - Atsukawa M AUID- ORCID: 0000-0003-3374-7111 AD - Division of Gastroenterology and Hepatology, Department of Internal Medicine, Nippon Medical School, Tokyo, Japan. FAU - Kawata, Kazuhito AU - Kawata K AUID- ORCID: 0000-0002-4986-8578 AD - Hepatology Division, Department of Internal Medicine II, Hamamatsu University School of Medicine, Hamamatsu, Japan. FAU - Tajiri, Kazuto AU - Tajiri K AUID- ORCID: 0000-0002-2373-8601 AD - Department of Gastroenterology, Toyama University Hospital, Toyama, Japan. FAU - Tani, Joji AU - Tani J AD - Department of Gastroenterology and Hepatology, Kagawa University, Kagawa, Japan. FAU - Ishikawa, Toru AU - Ishikawa T AUID- ORCID: 0000-0002-5470-9694 AD - Department of Gastroenterology, Saiseikai Niigata Hospital, Niigata, Japan. FAU - Morita, Masahiro AU - Morita M AD - Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan. FAU - Chishina, Hirokazu AU - Chishina H AD - Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan. FAU - Takita, Masahiro AU - Takita M AD - Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan. FAU - Hagiwara, Satoru AU - Hagiwara S AD - Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan. FAU - Minami, Yasunori AU - Minami Y AD - Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan. FAU - Kumada, Takashi AU - Kumada T AD - Department of Nursing, Gifu Kyoritsu University, Ogaki, Japan. FAU - Nishida, Naoshi AU - Nishida N AD - Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Osaka, Japan. FAU - Kodama, Yuzo AU - Kodama Y AD - Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan. LA - eng GR - 25K11194/Japan Society for the Promotion of Science/ GR - 24K10393/Japan Society for the Promotion of Science/ PT - Journal Article DEP - 20260320 PL - Netherlands TA - Hepatol Res JT - Hepatology research : the official journal of the Japan Society of Hepatology JID - 9711801 OTO - NOTNLM OT - "biomarkers"[MH] OT - "carcinoma, hepatocellular"[MH] OT - "drug resistance"[MH] OT - "gadolinium DTPA"[MH] OT - "immune checkpoint inhibitors"[MH] OT - "magnetic resonance imaging"[MH] OT - "treatment outcome"[MH] OT - "tumor microenvironment"[MH] OT - "wnt signaling pathway"[MH] EDAT- 2026/03/21 06:30 MHDA- 2026/03/21 06:31 CRDT- 2026/03/21 00:28 PHST- 2026/01/23 00:00 [revised] PHST- 2025/11/07 00:00 [received] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/03/21 06:31 [medline] PHST- 2026/03/21 06:30 [pubmed] PHST- 2026/03/21 00:28 [entrez] AID - 10.1111/hepr.70157 [doi] PST - ppublish SO - Hepatol Res. 2026 Jun;56(6):998-1006. doi: 10.1111/hepr.70157. Epub 2026 Mar 20. PMID- 41862701 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260722 IS - 1476-5497 (Electronic) IS - 0307-0565 (Linking) VI - 50 IP - 7 DP - 2026 Jul TI - A sequential deep learning model for predicting people with obesity in adults aged 18-64 using physical fitness variables. PG - 1451-1458 LID - 10.1038/s41366-026-02053-y [doi] AB - BACKGROUND/OBJECTIVES: Health of people with obesity is a global concern. We developed an explainable sequential deep learning model using nationally representative physical fitness data to predict people with obesity and to identify the most influential predictors. SUBJECTS/METHODS: We analyzed data from 204,334 adults collected between 2010 and 2023. A sequential neural network model was trained and evaluated using stratified 5-fold cross-validation. Model performance was assessed using accuracy, precision, recall, F1-score, and ROC-AUC, as well as MAE, MSE, and R(2). Explainability was examined using SHAP and LIME analyses to rank feature importance and interpret decision patterns. RESULTS: Across five stratified folds, the model achieved an overall accuracy of 0.87-0.88 (p < 0.001 vs. random). Fold 4 showed optimal performance (TN = 1,462; FN = 184; FP = 249; TP = 1,554), yielding an accuracy of 0.873 (precision = 0.866, recall = 0.855, F1 = 0.876, ROC-AUC = 0.95) and stabilizing at 20 epochs. For this model, MAE was 0.122, MSE was 0.041, and R(2) was 0.833, with an average prediction error of 0.171 for the first 50 samples. SHAP identified 20-m shuttle run estimated VO(2)max (importance = 0.339), gender (0.2481), and relative grip strength (0.135) as the top predictors. LIME (intercept = 0.511, predicted=0.668, R(2) = 0.995) indicated that low estimated VO(2)max ( < 28.71 ml/kg/min) and low relative grip strength ( < 38.17%) substantially increased the probability of obesity classification, particularly among females. CONCLUSIONS: This explainable sequential deep learning model accurately predicts people with obesity using physical fitness variables and highlights the critical role of cardiorespiratory fitness in obesity risk assessment and management. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Li, Xinxing AU - Li X AD - College of Wushu and Dance, Shenyang Sport University, Shenyang, China. FAU - Sung, Yunho AU - Sung Y AD - Health & Exercise Science Laboratory, Institute of Sports Science, Department of Physical Education, Seoul National University, Seoul, Republic of Korea. FAU - Zhang, Yanjie AU - Zhang Y AD - Physical Education Unit, School of Humanities and Social Science, The Chinese University of Hong Kong, Shenzhen, China. FAU - Lim, Byunggul AU - Lim B AD - Institute for Advancing Health Through Agriculture, Texas A&M University, College Station, TX, USA. FAU - Kim, Dae Young AU - Kim DY AD - Senior Exercise Rehabilitation Laboratory, Department of Gerokinesiology, Kyungil University, Gyeongsan, Republic of Korea. daeyoung@kiu.ac.kr. FAU - Bae, Jun-Hyun AU - Bae JH AUID- ORCID: 0000-0003-1918-9213 AD - Sports Omics Laboratory, Division of Sports Rehabilitation Medicine, Catholic Kwangdong University, Gangneung, Republic of Korea. junhyunb@cku.ac.kr. LA - eng PT - Journal Article DEP - 20260320 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM MH - Humans MH - *Physical Fitness/physiology MH - *Deep Learning MH - Female MH - *Obesity/epidemiology/diagnosis/physiopathology MH - Adult MH - Male MH - Middle Aged MH - Adolescent MH - Predictive Learning Models MH - Young Adult MH - Prediction Algorithms COIS- Competing interests: The authors declare no competing interests. Ethics approval: Approval was obtained by the Research Ethics Committee of Seoul National University (approval no. E2007/003-006). The procedures used in this study adhere to the tenets of the Declaration of Helsinki. The studies were conducted in accordance with local legislation and institutional requirements. Written informed consent for participants was not required from the participants, their legal guardians, or next of kin in accordance with the national legislation and institutional requirements. The informed consent was waived. EDAT- 2026/03/21 06:30 MHDA- 2026/07/23 05:37 CRDT- 2026/03/21 00:26 PHST- 2025/11/06 00:00 [received] PHST- 2026/02/26 00:00 [accepted] PHST- 2026/02/02 00:00 [revised] PHST- 2026/07/23 05:37 [medline] PHST- 2026/03/21 06:30 [pubmed] PHST- 2026/03/21 00:26 [entrez] AID - 10.1038/s41366-026-02053-y [pii] AID - 10.1038/s41366-026-02053-y [doi] PST - ppublish SO - Int J Obes (Lond). 2026 Jul;50(7):1451-1458. doi: 10.1038/s41366-026-02053-y. Epub 2026 Mar 20. PMID- 41862420 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1536-7290 (Electronic) IS - 1746-1391 (Print) IS - 1536-7290 (Linking) VI - 26 IP - 4 DP - 2026 Apr TI - Sprint Speed Measurement in a National Rugby Union Academy: An Equivalence Study of Three Measurement Systems, Age, and Playing Position. PG - e70154 LID - 10.1002/ejsc.70154 [doi] LID - e70154 AB - This study profiled the sprint speed of young male rugby union players in a national pathway academy, comparing different technologies for determining maximal velocity (V(max)), while also examining age-group and positional effects. Data were collected from 140 players using a 40 m sprint during a single testing day. The data included anthropometric measures (age, body mass, and height), split times (10 m, 20 m, 30 m, and 40 m), maximum momentum, V(max), and time to Vmax (tVmax), captured across three measurement systems: timing gates, local positioning systems (LPS), and foot-mounted inertial measurement units (IMU). Effects were interpreted using equivalence testing. Here, regions of practical equivalence were informed by practitioner opinion of the acceptable amount of measurement error when measuring maximal speed and target change values for sprint times. Measurement comparisons showed practical equivalence only for Vmax between timing gates and LPS, suggesting they could be used interchangeably. All age-group and positional differences were not practically important with 10-m metre sprint times being practically equivalent between backs and forwards. Our findings emphasise the importance of measurement choice during speed profiling to inform speed and momentum development for young rugby players. CI - (c) 2026 The Author(s). European Journal of Sport Science published by Wiley-VCH GmbH on behalf of European College of Sport Science. FAU - Wright, Andrew R AU - Wright AR AD - Institute for Sport, Physical Education and Health Sciences, University of Edinburgh, Edinburgh, UK. FAU - Weston, Matthew AU - Weston M AUID- ORCID: 0000-0002-9531-3004 AD - Institute for Sport, Physical Education and Health Sciences, University of Edinburgh, Edinburgh, UK. AD - Institute of Sport, Manchester Metropolitan University, Manchester, UK. FAU - Menzies, Fraser A AU - Menzies FA AUID- ORCID: 0009-0006-4717-3605 AD - High Performance Department, Scottish Rugby Union, Murrayfield Stadium, Edinburgh, UK. AD - Carnegie Applied Rugby Research (CARR) Centre, Leeds Beckett University, Leeds, UK. FAU - Ramirez-Lopez, Carlos AU - Ramirez-Lopez C AUID- ORCID: 0000-0003-1605-3484 AD - High Performance Department, Scottish Rugby Union, Murrayfield Stadium, Edinburgh, UK. AD - Carnegie Applied Rugby Research (CARR) Centre, Leeds Beckett University, Leeds, UK. FAU - Boyd, Andy J AU - Boyd AJ AD - High Performance Department, Scottish Rugby Union, Murrayfield Stadium, Edinburgh, UK. FAU - Barrett, Steve AU - Barrett S AD - Playermaker, London, UK. FAU - Turner, Anthony P AU - Turner AP AUID- ORCID: 0000-0003-1202-6649 AD - Institute for Sport, Physical Education and Health Sciences, University of Edinburgh, Edinburgh, UK. LA - eng PT - Journal Article PL - Germany TA - Eur J Sport Sci JT - European journal of sport science JID - 101146739 SB - IM MH - Humans MH - *Football/physiology MH - *Athletic Performance/physiology MH - *Running/physiology MH - Male MH - Young Adult MH - Age Factors MH - Adolescent MH - Geographic Information Systems PMC - PMC13140636 OTO - NOTNLM OT - assessment OT - momentum OT - team sports OT - velocity COIS- The author SB is an employee of the company which manufactures the foot-mounted IMU device in the current study. However, throughout the data collection and write up periods, to remove any bias, this author was not involved in any statistical analysis or data interpretation conducted within the current study. EDAT- 2026/03/21 00:34 MHDA- 2026/03/21 00:35 PMCR- 2026/03/20 CRDT- 2026/03/20 23:32 PHST- 2026/02/26 00:00 [revised] PHST- 2025/06/23 00:00 [received] PHST- 2026/02/27 00:00 [accepted] PHST- 2026/03/21 00:35 [medline] PHST- 2026/03/21 00:34 [pubmed] PHST- 2026/03/20 23:32 [entrez] PHST- 2026/03/20 00:00 [pmc-release] AID - EJSC70154 [pii] AID - 10.1002/ejsc.70154 [doi] PST - ppublish SO - Eur J Sport Sci. 2026 Apr;26(4):e70154. doi: 10.1002/ejsc.70154. PMID- 41861474 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 1879-1026 (Electronic) IS - 0048-9697 (Linking) VI - 1027 DP - 2026 Apr 25 TI - Chronic dietary exposure and arsenic availability in tea agro-ecosystems: Insights from free ion activity model and sobol sensitivity analysis. PG - 181703 LID - S0048-9697(26)00366-9 [pii] LID - 10.1016/j.scitotenv.2026.181703 [doi] AB - This study aimed to evaluate the potential health hazards allied with arsenic (As) pollution in tea-growing ecosystems, including groundwater, soil, and two types of tea leaves (mature leaves and leaves with a bud), in Assam, India. Samples were collected from two major tea-growing sites: Site 1 (Jorhat) and Site 2 (Sivasagar). Mean As concentrations in groundwater, soil, two leaf and a bud, and mature tea leaf at sites 1 and 2 were 0.087 and 0.072 mg/L, 0.19 and 0.12 mg/kg, 0.63 and 0.51 mg/kg, and 0.77 and 0.66 mg/kg, respectively. Soil physicochemical investigation indicated acidic conditions (pH 4.7-5.2) and varied organic carbon levels affected As solubility and absorption. Geochemical indices (Single Pollution Index: SPI, Enrichment Factor: EF, and Geo-accumulation Index: Igeo) revealed moderate to high contamination at Site 1. The Free Ion Activity Model (FIAM) and Self-Organizing Map (SOM) analysis validated that soil organic C (OC) and pH were key determinants of As translocation from soil to tea leaves. Spatial mapping (Geographic Information System: GIS) further elucidated site-specific As accumulation patterns. Human health risk evaluation found ingestion as predominant exposure route, with children demonstrating greater vulnerability. Despite hazard index (HI < 1) and cancer risk (CR < 10(-4)) levels being below critical thresholds, extended exposure may result in chronic health consequences. Sobol sensitivity analysis (SSA) highlighted that exposure-related factors play a critical role in arsenic-associated carcinogenic risk, emphasizing the importance of reducing human exposure through improved environmental management and monitoring strategies. Results emphasize that despite moderate As contamination, sustained monitoring and soil-water management interventions are essential to minimize exposure and ensure safe tea production in Assam's tea-growing regions. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Ghosh, Saibal AU - Ghosh S AD - Department of Analytical Services, Tocklai Tea Research Institute, Tea Research Association, Jorhat, 785008, Assam, India. Electronic address: ghosh.saibal.1989@gmail.com. FAU - Das, Piw AU - Das P AD - Department of Analytical Services, Tocklai Tea Research Institute, Tea Research Association, Jorhat, 785008, Assam, India. FAU - Kashyap, Bishwapran AU - Kashyap B AD - Department of Analytical Services, Tocklai Tea Research Institute, Tea Research Association, Jorhat, 785008, Assam, India. FAU - Das, Sristi AU - Das S AD - Agricultural and Ecological Research Unit, Indian Statistical Institute, Giridih, 815301, Jharkhand, India. FAU - Hussain, Nazneen AU - Hussain N AD - Department of Bio-Sciences, Assam Don Bosco University, Sonapur, 782402, Assam, India. FAU - Pal, Raktim AU - Pal R AD - Department of Analytical Services, Tocklai Tea Research Institute, Tea Research Association, Jorhat, 785008, Assam, India. Electronic address: r.pal@tocklai.net. LA - eng PT - Journal Article DEP - 20260319 PL - Netherlands TA - Sci Total Environ JT - The Science of the total environment JID - 0330500 RN - N712M78A8G (Arsenic) RN - 0 (Soil Pollutants) RN - 0 (Tea) RN - 0 (Soil) SB - IM MH - *Arsenic/analysis MH - *Soil Pollutants/analysis MH - *Tea/chemistry MH - *Dietary Exposure/statistics & numerical data/analysis MH - India MH - *Environmental Monitoring MH - Ecosystem MH - Soil/chemistry MH - Plant Leaves/chemistry OTO - NOTNLM OT - As contamination OT - FIAM OT - Health risk assessment OT - SOM OT - Sobol sensitivity analysis OT - Tea ecosystem COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/21 00:34 MHDA- 2026/04/19 17:46 CRDT- 2026/03/20 19:03 PHST- 2025/11/20 00:00 [received] PHST- 2026/02/16 00:00 [revised] PHST- 2026/03/08 00:00 [accepted] PHST- 2026/04/19 17:46 [medline] PHST- 2026/03/21 00:34 [pubmed] PHST- 2026/03/20 19:03 [entrez] AID - S0048-9697(26)00366-9 [pii] AID - 10.1016/j.scitotenv.2026.181703 [doi] PST - ppublish SO - Sci Total Environ. 2026 Apr 25;1027:181703. doi: 10.1016/j.scitotenv.2026.181703. Epub 2026 Mar 19. PMID- 41861418 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 88 DP - 2026 May-Jun TI - Post-discharge feeding problems and associated factors in children undergoing congenital heart surgery: A descriptive cross-sectional study. PG - 477-484 LID - S0882-5963(26)00127-2 [pii] LID - 10.1016/j.pedn.2026.03.015 [doi] AB - BACKGROUND AND AIM: Feeding difficulties are common after congenital heart surgery and may affect growth, development, and caregiver well-being. This study aimed to determine the prevalence and types of post-discharge feeding difficulties and examine associated medical, demographic, and socioeconomic factors. MATERIAL AND METHODS: This descriptive cross-sectional study included 177 children. The study involved children with CHD followed at a pediatric cardiovascular surgery clinic, who underwent surgery within the first two years of life and were 6-60 months postoperatively; data were collected between April-May 2025. Data were collected from caregivers via telephone using a validated Patient Information and Follow-up Form. Statistical analyses included chi-square tests and multivariate logistic regression to identify predictors of post-discharge feeding problems. RESULTS: Post-discharge feeding difficulties were reported in 70.1% of participants. The most frequent problems included inadequate weight gain (45.8%), food refusal (31.6%), and fatigue during feeding (28.8%). Multivariate regression identified lower paternal education (OR = 6.32), postoperative complications (OR = 6.14), mixed feeding (OR = 7.60), and difficulties during complementary feeding (OR = 0.014) as significant predictors. Protective factors included obstructive-type heart defects (OR = 0.05) and higher family income (OR = 0.084). Only 0.6% of families received professional feeding support. CONCLUSION: Post-discharge feeding problems are common in children after congenital heart surgery and are associated with clinical and socioeconomic factors. Structured discharge planning, early risk identification, and multidisciplinary follow-up are essential to improve nutritional outcomes. IMPLICATIONS TO PRACTICE: Routine feeding assessment and caregiver education should be included in discharge planning. Early identification of high-risk families and multidisciplinary follow-up may help prevent feeding problems and support recovery. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Ercan-Koyuncu, Ilcim AU - Ercan-Koyuncu I AD - Baskent University, Faculty of Health Sciences, Department of Pediatric Nursing, Ankara, Turkiye. Electronic address: ilcimercan@hotmail.com. FAU - Ay, Ayse AU - Ay A AD - Baskent University, Faculty of Health Sciences, Department of Pediatric Nursing, Ankara, Turkiye. FAU - Adam, Neslihan AU - Adam N AD - Baskent University Ankara Hospital, Nursing Services Directorate, Ankara, Turkiye. FAU - Uslu, Gulsah AU - Uslu G AD - Baskent University Ankara Hospital, Nursing Services Directorate, Ankara, Turkiye. FAU - Eroglu, Gulizar Kilic AU - Eroglu GK AD - Baskent University Ankara Hospital, Nursing Services Directorate, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260319 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - *Heart Defects, Congenital/surgery MH - Male MH - Infant MH - *Patient Discharge MH - *Cardiac Surgical Procedures/adverse effects MH - Child, Preschool MH - *Postoperative Complications/epidemiology MH - Infant, Newborn MH - Risk Factors MH - *Feeding Behavior OTO - NOTNLM OT - Congenital OT - Feeding OT - Heart disease OT - Nursing care OT - Nutrition disorders COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/21 00:34 MHDA- 2026/05/09 00:34 CRDT- 2026/03/20 18:59 PHST- 2025/08/04 00:00 [received] PHST- 2026/03/12 00:00 [revised] PHST- 2026/03/12 00:00 [accepted] PHST- 2026/05/09 00:34 [medline] PHST- 2026/03/21 00:34 [pubmed] PHST- 2026/03/20 18:59 [entrez] AID - S0882-5963(26)00127-2 [pii] AID - 10.1016/j.pedn.2026.03.015 [doi] PST - ppublish SO - J Pediatr Nurs. 2026 May-Jun;88:477-484. doi: 10.1016/j.pedn.2026.03.015. Epub 2026 Mar 19. PMID- 41861073 OWN - NLM STAT- Publisher LR - 20260320 IS - 2047-4881 (Electronic) IS - 2047-4873 (Linking) DP - 2026 Mar 20 TI - Normative values for cardiopulmonary exercise testing in the pediatric population - an updated systematic review. LID - zwag168 [pii] LID - 10.1093/eurjpc/zwag168 [doi] AB - AIMS: Normative data for cardiopulmonary exercise testing (CPET) provide benchmarks of aerobic fitness that change throughout the lifespan, with new scaling techniques often developed and differing between adults and children/adolescents. Considering the recent interest in the pediatric population for CPET studies, this systematic review aimed to update pediatric-specific CPET reference values. METHODS AND RESULTS: A systematic review was performed according to the PRISMA guidelines from February 1, 2019, to December 31, 2025, from 6 scientific databases. Observational studies in any language, presenting data from maximal CPET, and conducted only on healthy participants <18 years old were included. Primary outcomes included reference values for peak oxygen uptake (V̇O2peak), and secondary outcomes included other variables assessed during CPET. Risk of bias was assessed with the 14-point ATS/ACCP statement for CPET and the 8-point JBI Critical Appraisal Tool. 15 studies conducted on 12,083 participants (5,886 [49.4%] females) were included, of which recruitment was hospital-based in 6 studies, community-based in 8 studies, and athlete-specific in 1 study. 6 studies reported ethnicity, with most participants classified as white, while 1 investigation presented exclusive data for obese/overweight or pediatric athletic cohorts. Normative V̇O2peak ranged between 26.0-56.3 mL.kg-1.min-1, peak heart rate between 175-199 bpm, and peak ventilation between 52.2-96.0 L.min-1. Reference equations were developed in 11 studies, with 5 of these studies validating the derived equations. A high heterogeneity was observed between studies of high- (n=2), moderate- (n=9), and low-quality (n=4), with ATS/ACCP statement and JBI Critical Appraisal Tool often disregarded - although quality level did not influence study outcomes. CONCLUSION: Updated normative values for CPET varied significantly in pediatric cohorts. While female representation matched male, and more studies considering pediatric athletes, showing a positive trend change from previous investigations, obese and overweight children/adolescents, as well as non-white participants, remained underrepresented. Considering the differences in normative data between pediatric cohorts of differing characteristics, clinicians should use reference values derived from cohorts closely matching their patients' characteristics. PROSPERO REGISTRATION NUMBER: CRD420251137402. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the European Society of Cardiology. FAU - Kasiak, Przemyslaw AU - Kasiak P AUID- ORCID: 0000-0002-0303-6135 AD - 3rd Department of Internal Medicine and Cardiology; Medical University of Warsaw, Warsaw, Poland. FAU - Kowalski, Tomasz AU - Kowalski T AUID- ORCID: 0000-0003-1333-1725 AD - Department of Physiology; Institute of Sport-National Research Institute, Warsaw, Poland. FAU - Zanini, Michele AU - Zanini M AUID- ORCID: 0009-0007-8148-8843 AD - School of Sport, Exercise, and Health Sciences; Loughborough University, Loughborough, UK. AD - School of Education, Childhood, Youth and Sport; The Open University, Milton Keynes, UK. FAU - Ozemek, Cemal AU - Ozemek C AUID- ORCID: 0000-0003-2644-215X AD - Department of Physical Therapy, College of Applied Health Sciences; University of Illinois Chicago, Chicago, Illinois, USA. FAU - Faiss, Raphael AU - Faiss R AUID- ORCID: 0000-0001-6029-9516 AD - Institute of Sports Sciences, Department of Physiology, Faculty of Biology and Medicine; University of Lausanne, Lausanne, Switzerland. FAU - Debevec, Tadej AU - Debevec T AUID- ORCID: 0000-0001-7053-3978 AD - Faculty of Sport; University of Ljubljana, Ljubljana, Slovenia. AD - Department of Automatics, Biocybernetics and Robotics; Jozef Stefan Institute, Ljubljana, Slovenia. FAU - Mamcarz, Artur AU - Mamcarz A AUID- ORCID: 0000-0002-9569-1486 AD - 3rd Department of Internal Medicine and Cardiology; Medical University of Warsaw, Warsaw, Poland. FAU - Sliz, Daniel AU - Sliz D AUID- ORCID: 0000-0001-5917-8119 AD - 3rd Department of Internal Medicine and Cardiology; Medical University of Warsaw, Warsaw, Poland. FAU - Chomiuk, Tomasz AU - Chomiuk T AUID- ORCID: 0000-0003-1341-327X AD - 3rd Department of Internal Medicine and Cardiology; Medical University of Warsaw, Warsaw, Poland. FAU - Ragazzoni, Gian Luca AU - Ragazzoni GL AUID- ORCID: 0000-0003-2915-0806 AD - Department of Medical Biotechnologies, Sports Cardiology and Rehab Unit, University of Siena, Siena, Italy. AD - Centre for Inherited Cardiovascular Diseases, Great Ormond Street Hospital, London, UK. FAU - Arena, Ross AU - Arena R AUID- ORCID: 0000-0002-6675-1996 AD - Department of Physical Therapy, College of Applied Health Sciences; University of Illinois Chicago, Chicago, Illinois, USA. FAU - D'Ascenzi, Flavio AU - D'Ascenzi F AUID- ORCID: 0000-0002-0947-6836 AD - Department of Medical Biotechnologies, Sports Cardiology and Rehab Unit, University of Siena, Siena, Italy. FAU - Takken, Tim AU - Takken T AUID- ORCID: 0000-0002-7737-118X AD - Department of Medical Physiology, Child Development and Exercise Center, Wilhelmina Children's Hospital; University Medical Center Utrecht, Utrecht, the Netherlands. LA - eng PT - Journal Article DEP - 20260320 PL - England TA - Eur J Prev Cardiol JT - European journal of preventive cardiology JID - 101564430 SB - IM OAB - Cardiopulmonary exercise testing (CPET) have recently gained particular interest in the pediatric population, and updated CPET reference values and normalization techniques were systematically summarized and found to vary significantly between studies and children of different characteristics.Despite an equal representation of males and females as well as hospital- and community-based populations and ongoing advances in normative data for pediatric athletes, overweighted/obese children/adolescents, and non-white participants remain underrepresented in recent CPET research.Considering the differences in normative data between pediatric cohorts assessed, clinicians should use reference values derived from cohorts closely matching their patients characteristics. OABL- eng OTO - NOTNLM OT - CPET OT - Reference values OT - cardiopulmonary exercise testing OT - cardiorespiratory fitness OT - children OT - normative data OT - pediatric population EDAT- 2026/03/20 18:37 MHDA- 2026/03/20 18:37 CRDT- 2026/03/20 14:24 PHST- 2025/10/21 00:00 [received] PHST- 2026/01/05 00:00 [revised] PHST- 2026/03/20 18:37 [medline] PHST- 2026/03/20 18:37 [pubmed] PHST- 2026/03/20 14:24 [entrez] AID - 8530634 [pii] AID - 10.1093/eurjpc/zwag168 [doi] PST - aheadofprint SO - Eur J Prev Cardiol. 2026 Mar 20:zwag168. doi: 10.1093/eurjpc/zwag168. PMID- 41859877 OWN - NLM STAT- Publisher LR - 20260320 IS - 1469-8749 (Electronic) IS - 0012-1622 (Linking) DP - 2026 Mar 20 TI - Environmental supportiveness, physical activity, and sedentary time in children with cerebral palsy. LID - 10.1111/dmcn.70253 [doi] AB - AIM: To describe how movement behaviours (sedentary time, light-intensity physical activity, moderate-to-vigorous physical activity [MVPA]) and parent-reported community physical activity participation vary across levels of environmental supportiveness (home, school, community) in children with cerebral palsy (CP). METHOD: This was a secondary cross-sectional observational study using pooled data (n = 141) from four studies of children with CP aged 6 to 16 years (mean = 10 years 1 month [SD = 2 years 5 months]; Gross Motor Function Classification System level I = 71, level II = 41, levels III-IV = 29). Children wore hip-mounted triaxial accelerometers; validated machine-learning models classified sedentary time, light physical activity, and MVPA. Parents reported community physical activity participation and environmental supportiveness using the Participation and Environment Measure for Children and Youth. Linear models were adjusted for wear time and study. We estimated marginal mean differences (MMDs) in time spent in movement behaviours between the 25th and 75th centiles of supportiveness scores. RESULTS: Greater community (MMD = -30.1 minutes, 95% confidence interval [CI] = -53.4 to -8.1), home (-31.4 min, 95% CI = -51.5 to -11.3), and school (MMD = -54.1 min, 95% CI = -76.0 to -32.2) supportiveness were associated with less sedentary time. Higher home supportiveness was associated with more time in light physical activity (MMD = 23.7 minutes, 95% CI = 11.0 to 36.3), whereas school and community supportiveness were not associated with light physical activity. No environmental supportiveness measures were associated with time in MVPA. INTERPRETATION: Greater environmental supportiveness across all contexts was associated with lower sedentary time, while greater home supportiveness was associated with more time in light physical activity. Other factors may have stronger associations with MVPA time. CI - (c) 2026 The Author(s). Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press. FAU - Oftedal, Stina AU - Oftedal S AUID- ORCID: 0000-0002-6769-1454 AD - Queensland Cerebral Palsy and Rehabilitation Research Centre, University of Queensland, Brisbane, Queensland, Australia. FAU - Armstrong, Ellen AU - Armstrong E AD - Queensland Cerebral Palsy and Rehabilitation Research Centre, University of Queensland, Brisbane, Queensland, Australia. FAU - Kilgour, Gaela AU - Kilgour G AUID- ORCID: 0000-0002-8867-7782 AD - Queensland Cerebral Palsy and Rehabilitation Research Centre, University of Queensland, Brisbane, Queensland, Australia. FAU - Ahmadi, Matthew AU - Ahmadi M AD - School of Health Sciences, Faculty of Medicine and Health, University of Sydney, Sydney, New South Wales, Australia. FAU - Trost, Stewart G AU - Trost SG AD - School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Queensland, Australia. FAU - Horan, Sean A AU - Horan SA AD - Menzies Health Institute Queensland and School of Allied Health Sciences, Griffith University, Queensland, Australia. FAU - Carty, Christopher AU - Carty C AD - School of Allied Health Sciences and Gold Coast Orthopaedic Research Engineering and Education Alliance, Menzies Health Institute Queensland, Griffith University, Queensland, Australia. FAU - Brookes, Denise AU - Brookes D AD - School of Human Movement and Nutrition Sciences, University of Queensland, Brisbane, Queensland, Australia. FAU - Boyd, Roslyn N AU - Boyd RN AUID- ORCID: 0000-0002-4919-5975 AD - Queensland Cerebral Palsy and Rehabilitation Research Centre, University of Queensland, Brisbane, Queensland, Australia. FAU - Sakzewski, Leanne AU - Sakzewski L AUID- ORCID: 0000-0001-5395-544X AD - Queensland Cerebral Palsy and Rehabilitation Research Centre, University of Queensland, Brisbane, Queensland, Australia. FAU - Reedman, Sarah E AU - Reedman SE AUID- ORCID: 0000-0002-3937-5649 AD - Queensland Cerebral Palsy and Rehabilitation Research Centre, University of Queensland, Brisbane, Queensland, Australia. LA - eng GR - Merchant Charitable Foundation donation ID 10415/Children's Hospital Foundation/ GR - 1077257/National Health and Medical Research Council/ GR - 1140756/National Health and Medical Research Council/ GR - PG3915/Cerebral Palsy Alliance Research Foundation/ PT - Journal Article DEP - 20260320 PL - England TA - Dev Med Child Neurol JT - Developmental medicine and child neurology JID - 0006761 SB - IM EDAT- 2026/03/20 07:10 MHDA- 2026/03/20 07:10 CRDT- 2026/03/20 05:43 PHST- 2026/02/16 00:00 [revised] PHST- 2025/03/02 00:00 [received] PHST- 2026/02/18 00:00 [accepted] PHST- 2026/03/20 07:10 [medline] PHST- 2026/03/20 07:10 [pubmed] PHST- 2026/03/20 05:43 [entrez] AID - 10.1111/dmcn.70253 [doi] PST - aheadofprint SO - Dev Med Child Neurol. 2026 Mar 20. doi: 10.1111/dmcn.70253. PMID- 41859864 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260903 IS - 1879-3479 (Electronic) IS - 0020-7292 (Print) IS - 0020-7292 (Linking) VI - 174 IP - 3 DP - 2026 Sep TI - Comparison of cerebro-placental-uterine ratio between patients with gestational diabetes mellitus and healthy pregnant women: A prospective tertiary center observational study. PG - 1436-1444 LID - 10.1002/ijgo.70936 [doi] AB - OBJECTIVE: The aim of this study was to evaluate the cerebroplacental ratio (CPR) and the cerebroplacental-uterine ratio (CPUR) in pregnancies complicated by gestational diabetes mellitus (GDM) and to determine the role of these indices in predicting adverse perinatal outcomes. METHODS: This prospective, single-center observational study was conducted at a tertiary care institution between August 2024 and January 2025. A total of 117 pregnant women were enrolled, including 64 with GDM (group 1) and 53 without GDM (group 2). The GDM group was further subdivided according to treatment modality (diet-controlled vs. insulin-treated). Doppler parameters, as well as maternal and fetal outcomes, were compared between the groups. RESULTS: In the GDM group, body mass index (BMI) (P < 0.001), cesarean delivery rate (P = 0.037), and neonatal intensive care unit (NICU) admissions (P = 0.010) were significantly higher, whereas gfestational age at delivery (P = 0.016), first and fifth minute Apgar scores, and umbilical cord PH were significantly lower (P < 0.05). The umbilical artery pulsatility index (UA-PI) was significantly elevated in the GDM group, while CPR (P < 0.001) and CPUR (P < 0.001) were significantly lower. Both CPR and CPUR were significant predictors of adverse fetal outcomes. In the study group, the receiver operating characteristic analysis for CPR predicting NICU admission yielded an optimal cut-off value of 1.45 (area under the curve [AUC] = 0.725; P = 0.001), with 69.2% sensitivity and 69.2% specificity. For CPUR, the optimal cut-off was 1.37 (AUC = 0.761; P = 0.001), with 73.1% sensitivity and 72.5% specificity. CONCLUSION: In patients with GDM, both CPR and CPUR were significantly lower compared to healthy pregnancies, and CPUR was shown to be a clinically useful predictor of adverse fetal outcomes. CI - (c) 2026 International Federation of Gynecology and Obstetrics. FAU - Kayaalp, Huseyin AU - Kayaalp H AUID- ORCID: 0009-0001-8372-0518 AD - Ankara Bilkent City Hospital, Department of Obstetrics and Gynecology, Perinatology Unit, University of Health Sciences, Ankara, Turkey. FAU - Tanacan, Atakan AU - Tanacan A AUID- ORCID: 0009-0002-3278-7728 AD - Ankara Bilkent City Hospital, Department of Obstetrics and Gynecology, Perinatology Unit, University of Health Sciences, Ankara, Turkey. FAU - Altinboga, Orhan AU - Altinboga O AUID- ORCID: 0000-0001-9992-8535 AD - Ankara Bilkent City Hospital, Department of Obstetrics and Gynecology, Perinatology Unit, University of Health Sciences, Ankara, Turkey. FAU - Paksoy, Enes AU - Paksoy E AUID- ORCID: 0009-0009-8084-4513 AD - Ankara Bilkent City Hospital, Department of Obstetrics and Gynecology, Perinatology Unit, University of Health Sciences, Ankara, Turkey. FAU - Ozdal, Burcu Bozkurt AU - Ozdal BB AUID- ORCID: 0009-0007-6644-3890 AD - Ankara Bilkent City Hospital, Department of Obstetrics and Gynecology, Perinatology Unit, University of Health Sciences, Ankara, Turkey. FAU - Bal, Ayse Altindis AU - Bal AA AUID- ORCID: 0009-0003-3471-8205 AD - Ankara Bilkent City Hospital, Department of Obstetrics and Gynecology, Perinatology Unit, University of Health Sciences, Ankara, Turkey. FAU - Ocal, Fatma Doga AU - Ocal FD AUID- ORCID: 0000-0003-4727-7982 AD - Ankara Bilkent City Hospital, Department of Obstetrics and Gynecology, Perinatology Unit, University of Health Sciences, Ankara, Turkey. FAU - Sahin, Dilek AU - Sahin D AUID- ORCID: 0000-0001-8567-9048 AD - Ankara Bilkent City Hospital, Department of Obstetrics and Gynecology, Perinatology Unit, University of Health Sciences, Ankara, Turkey. LA - eng PT - Comparative Study PT - Journal Article PT - Observational Study DEP - 20260320 PL - United States TA - Int J Gynaecol Obstet JT - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JID - 0210174 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Diabetes, Gestational/physiopathology/diagnostic imaging MH - Prospective Studies MH - Adult MH - *Umbilical Arteries/diagnostic imaging MH - *Middle Cerebral Artery/diagnostic imaging MH - Pregnancy Outcome MH - Tertiary Care Centers MH - Ultrasonography, Prenatal MH - *Placenta/diagnostic imaging/blood supply MH - Infant, Newborn MH - Cesarean Section/statistics & numerical data MH - Pulsatile Flow MH - ROC Curve MH - Ultrasonography, Doppler MH - Body Mass Index MH - Case-Control Studies PMC - PMC13505286 OTO - NOTNLM OT - cerebro-placental-uterine ratio OT - cerebro-placental ratio OT - gestational diabetes mellitus OT - neonatal intensive care unit OT - pregnancy OT - umblical artery pulsatility index COIS- The authors declare that there is no conflict of interest. EDAT- 2026/03/20 07:10 MHDA- 2026/08/25 11:38 PMCR- 2026/08/25 CRDT- 2026/03/20 05:33 PHST- 2026/02/06 00:00 [revised] PHST- 2025/11/27 00:00 [received] PHST- 2026/02/18 00:00 [accepted] PHST- 2026/08/25 11:38 [medline] PHST- 2026/03/20 07:10 [pubmed] PHST- 2026/03/20 05:33 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - IJGO70936 [pii] AID - 10.1002/ijgo.70936 [doi] PST - ppublish SO - Int J Gynaecol Obstet. 2026 Sep;174(3):1436-1444. doi: 10.1002/ijgo.70936. Epub 2026 Mar 20. PMID- 41859786 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260820 IS - 1601-6343 (Electronic) IS - 1601-6335 (Print) IS - 1601-6335 (Linking) VI - 29 IP - 4 DP - 2026 Aug TI - 3D Gaussian Splatting vs. 2D Photogrammetry and Direct Anthropometry for Facial Measurements. PG - 688-697 LID - 10.1111/ocr.70116 [doi] AB - BACKGROUND: This study evaluates the accuracy and repeatability of 3D Gaussian Splatting (3DGS)-generated 3D facial models by comparing anthropometric measurements derived from these models with those obtained using conventional 2D photogrammetry and direct anthropometry. METHODS: In this cross-sectional study, 58 adults (18-25 years) underwent direct anthropometry, standardised 2D photography with calibration, and 3DGS facial reconstruction using a smartphone-based workflow. A predefined set of linear and angular facial measurements was recorded; each measurement was repeated three times by the same observer. Between-method comparisons were performed using paired tests as appropriate. Pearson correlation coefficients were reported to describe association, whereas agreement and potential interchangeability were evaluated primarily using Bland-Altman bias and 95% limits of agreement (LoA); plots were additionally inspected for proportional bias and influential outliers. RESULTS: 3DGS demonstrated small mean differences relative to direct anthropometry for several measurements, with generally narrower LoA than 2D photogrammetry. Correlations were typically higher for 3DGS than for 2D photogrammetry; however, Bland-Altman analyses indicated that agreement varied by variable. For selected measurements, LoA were wide (reaching approximately 10-18 mm for some linear outcomes and exceeding 20 degrees for certain angular outcomes), indicating limited interchangeability for individual-level clinical decisions. Perioral measures showed greater dispersion for 2D photogrammetry, particularly for N-Stm, and a small number of observations fell outside the 95% LoA in ANT vs. 2D comparisons, consistent with occasional landmark identification or reconstruction-related variability. CONCLUSION: 3D Gaussian Splatting (3DGS) may offer a useful alternative workflow for selected facial analysis applications by enabling the generation of measurable three-dimensional facial models, from which anthropometric variables can subsequently be derived. Although 2D photogrammetry is readily accessible and practical to implement, its inherent limitation in representing three-dimensional anatomy may compromise measurement accuracy in certain clinical contexts. Overall, these findings indicate that 3DGS could support orthodontic practice and research as a 3D model-generation technique; however, further validation across diverse patient groups, acquisition conditions, expanded landmark-based geometric error metrics, and additional outcome measures is warranted before routine clinical adoption can be recommended. CI - (c) 2026 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd. FAU - Genc, Celal AU - Genc C AD - Department of Orthodontics, Faculty of Dentistry, Canakkale Onsekiz Mart University, Canakkale, Turkiye. FAU - Arisan, Arda AU - Arisan A AUID- ORCID: 0009-0004-8920-8605 AD - Private Practice, Ankara, Turkiye. FAU - Toprak, Mert AU - Toprak M AUID- ORCID: 0009-0003-4698-4586 AD - Department of Orthodontics, Faculty of Dentistry, Canakkale Onsekiz Mart University, Canakkale, Turkiye. FAU - Duran, Gokhan Serhat AU - Duran GS AUID- ORCID: 0000-0001-6152-6178 AD - Department of Orthodontics, Faculty of Dentistry, Canakkale Onsekiz Mart University, Canakkale, Turkiye. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260320 PL - England TA - Orthod Craniofac Res JT - Orthodontics & craniofacial research JID - 101144387 SB - IM MH - Humans MH - *Photogrammetry/methods/statistics & numerical data MH - *Imaging, Three-Dimensional/methods/statistics & numerical data MH - *Face/anatomy & histology/diagnostic imaging MH - Cross-Sectional Studies MH - Young Adult MH - Reproducibility of Results MH - Adolescent MH - Adult MH - Female MH - Male MH - Normal Distribution MH - Image Processing, Computer-Assisted/methods/statistics & numerical data MH - *Anthropometry/methods MH - Photography MH - Smartphone MH - Cephalometry/methods/statistics & numerical data MH - Calibration PMC - PMC13485164 OTO - NOTNLM OT - 3D gaussian splatting OT - digital imaging OT - facial anthropometry OT - measurement accuracy OT - orthodontic diagnosis COIS- The authors declare no conflicts of interest. EDAT- 2026/03/20 07:10 MHDA- 2026/08/18 17:37 PMCR- 2026/08/18 CRDT- 2026/03/20 05:02 PHST- 2026/01/28 00:00 [revised] PHST- 2025/10/17 00:00 [received] PHST- 2026/03/06 00:00 [accepted] PHST- 2026/08/18 17:37 [medline] PHST- 2026/03/20 07:10 [pubmed] PHST- 2026/03/20 05:02 [entrez] PHST- 2026/08/18 00:00 [pmc-release] AID - OCR70116 [pii] AID - 10.1111/ocr.70116 [doi] PST - ppublish SO - Orthod Craniofac Res. 2026 Aug;29(4):688-697. doi: 10.1111/ocr.70116. Epub 2026 Mar 20. PMID- 41859655 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260320 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Key dietary amino acids modulating overweight/obesity risk in Chinese children and adolescents: a machine learning analysis of a national survey. PG - 1769111 LID - 10.3389/fnut.2026.1769111 [doi] LID - 1769111 AB - OBJECTIVE: To mitigate current research limitations, this cross-sectional study aimed to systematically evaluate the associations between dietary amino acids and overweight/obesity and to identify critical biomarkers among Chinese children and adolescents. This was achieved by integrating multiple machine learning algorithms with traditional statistical models. METHODS: This study utilized data from the 2016-2019 China Children and Lactating Women Nutrition and Health Surveillance, a nationally representative survey. Participants included children and adolescents aged 6-18 years. Dietary intake was assessed using a validated food frequency questionnaire, and amino acid intakes were calculated. Four machine learning algorithms were applied to build prediction models. Model performance was evaluated via the area under the receiver operating characteristic curve (AUC). The SHapley Additive exPlanations (SHAP) method was used to interpret the optimal model and identify important features. Multivariable logistic regression models were additionally used to examine the relationship between amino acids and overweight/obesity risk. RESULTS: A total of 8,664 participants were included. The LightGBM model showed the best predictive effect (AUC = 0.805). Both SHAP analysis and logistic regression results consistently identified leucine (OR 1.13; 95% CI 1.01 ~ 1.27), threonine (OR 1.41; 95% CI 1.22 ~ 1.63), methionine (OR 1.30; 95% CI 1.07 ~ 1.57), and cysteine (OR 0.71; 95% CI 0.59 ~ 0.84) as key amino acids associated with overweight/obesity risk. After multivariable adjustment, the intake of leucine, threonine, and methionine was positively related to the risk of overweight/obesity, whereas cysteine intake was inversely related to the risk. Restricted cubic spline analyses suggested linear relationships for these associations. CONCLUSION: Higher dietary intakes of leucine, threonine, and methionine are potential risk factors, while cysteine is a potential protective factor against overweight/obesity in Chinese children and adolescents. CI - Copyright (c) 2026 Liu, Li, Zhang, Liu, Liu, Tian, Zhu, Chen, Yu and Wang. FAU - Liu, Qiangqiang AU - Liu Q AD - Department of Internal Medicine, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, China. FAU - Li, Cheng AU - Li C AD - Department of Clinical Nutrition, Beijing Friendship Hospital, Capital Medical University, Beijing, China. FAU - Zhang, Yifan AU - Zhang Y AD - School of Public Health, Southern Medical University, Guangzhou, China. FAU - Liu, Changqing AU - Liu C AD - Hebei Center for Disease Control and Prevention, Shijiazhuang, China. FAU - Liu, Yiya AU - Liu Y AD - Guizhou Center for Disease Control and Prevention, Guiyang, China. FAU - Tian, Meina AU - Tian M AD - Hebei Center for Disease Control and Prevention, Shijiazhuang, China. FAU - Zhu, Qianrang AU - Zhu Q AD - Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China. FAU - Chen, Yao AU - Chen Y AD - Clinical Nutrition Department, People's Hospital of Rizhao, Rizhao, China. FAU - Yu, Lianlong AU - Yu L AD - Shandong Center for Disease Control and Prevention, Jinan, China. FAU - Wang, Hongwei AU - Wang H AD - Department of Health Care, People's Hospital of Rizhao, Rizhao, China. LA - eng PT - Journal Article DEP - 20260304 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12995779 OTO - NOTNLM OT - adolescents OT - children OT - dietary amino acids OT - machine learning OT - obesity OT - overweight COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/20 07:10 MHDA- 2026/03/20 07:11 PMCR- 2026/03/04 CRDT- 2026/03/20 04:56 PHST- 2025/12/16 00:00 [received] PHST- 2026/01/20 00:00 [revised] PHST- 2026/02/19 00:00 [accepted] PHST- 2026/03/20 07:11 [medline] PHST- 2026/03/20 07:10 [pubmed] PHST- 2026/03/20 04:56 [entrez] PHST- 2026/03/04 00:00 [pmc-release] AID - 10.3389/fnut.2026.1769111 [doi] PST - epublish SO - Front Nutr. 2026 Mar 4;13:1769111. doi: 10.3389/fnut.2026.1769111. eCollection 2026. PMID- 41858994 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260320 LR - 20260813 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Acute effects of strength training interventions on subjective, neuromuscular, and biochemical fatigue parameters in elite youth soccer players. PG - 1742295 LID - 10.3389/fspor.2026.1742295 [doi] LID - 1742295 AB - This study examined acute neuromuscular, biochemical, and subjective fatigue responses to two strength training protocols-back squats with calf raises vs. back squats with plyometric exercises-in elite youth soccer players. The aim was to track the progression and resolution of fatigue over a 72 h recovery period and evaluate the practical feasibility of both protocols within high-performance training schedules. Thirty-two male athletes from a national youth elite training center participated in a crossover-controlled study. Each player completed both interventions, separated by an 8-day washout period. A comprehensive test battery assessed neuromuscular performance via the countermovement jump (CMJ), drop jump, isometric mid-thigh pull, adductor squeeze, and sit-and-reach test; biochemical markers via creatine kinase (CK); and subjective markers using the Hooper Index, visual analog scale (VAS), and session rating of perceived exertion (sRPE). Measurements were taken at baseline and 24, 48, and 72 h post-exercise. No significant interaction effects (training modality x time) were found (p > 0.05), indicating comparable fatigue and recovery trajectories for both protocols, whereas significant main effects of time were observed across all parameters, including CMJ [F(3,26) = 29.373, p < 0.001, eta (2) = 0.772] and CK [F(3,26) = 51.504, p < 0.001, eta (2) = 0.856]. Fatigue peaked between 24 and 48 h post-exercise and returned to baseline by 72 h. Subjective fatigue (Hooper, VAS) mirrored objective markers. Both traditional and reactive strength training induced short-term fatigue that resolved within 72 h, supporting their safe implementation in elite youth training programs, provided adequate recovery is allowed between sessions. CI - (c) 2026 Kadlubowski, Keiner, Wirth and Csapo. FAU - Kadlubowski, Bjorn AU - Kadlubowski B AD - Centre for Sport Science and University Sports, Department of Sport and Human Movement Science, University of Vienna, Vienna, Austria. AD - Vienna Doctoral School of Pharmaceutical, Nutritional and Sport Sciences, University of Vienna, Vienna, Austria. FAU - Keiner, Michael AU - Keiner M AD - Department of Training and Exercise Science, German University of Health and Sport, Berlin, Germany. FAU - Wirth, Klaus AU - Wirth K AD - Department of Sport Science, University of Applied Sciences Wiener Neustadt, Wiener Neustadt, Austria. FAU - Csapo, Robert AU - Csapo R AD - Centre for Sport Science and University Sports, Department of Sport and Human Movement Science, University of Vienna, Vienna, Austria. LA - eng PT - Journal Article DEP - 20260304 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC12996250 OTO - NOTNLM OT - creatine kinase OT - monitoring OT - performance OT - plyometric OT - recovery COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/20 07:10 MHDA- 2026/03/20 07:11 PMCR- 2026/03/04 CRDT- 2026/03/20 04:50 PHST- 2025/11/08 00:00 [received] PHST- 2026/02/09 00:00 [revised] PHST- 2026/02/16 00:00 [accepted] PHST- 2026/03/20 07:11 [medline] PHST- 2026/03/20 07:10 [pubmed] PHST- 2026/03/20 04:50 [entrez] PHST- 2026/03/04 00:00 [pmc-release] AID - 10.3389/fspor.2026.1742295 [doi] PST - epublish SO - Front Sports Act Living. 2026 Mar 4;8:1742295. doi: 10.3389/fspor.2026.1742295. eCollection 2026. PMID- 41858715 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260320 LR - 20260813 IS - 1179-1608 (Print) IS - 1179-1608 (Electronic) IS - 1179-1608 (Linking) VI - 18 DP - 2026 TI - Integrative Assessment of Cephalometric and Polysomnographic Features in Paediatric Obstructive Sleep Apnea: A Cross-Sectional Study. PG - 574045 LID - 10.2147/NSS.S574045 [doi] LID - 574045 AB - OBJECTIVE: This study aimed to characterize pediatric patients with suspected sleep-disordered breathing (SDB) and evaluate whether cephalometric features and clinical indicators can predict obstructive sleep apnea (OSA) severity, as confirmed by polysomnography (PSG). METHODS: A cross-sectional study was conducted among 228 children referred for sleep-related breathing concerns. Data collected included demographics, clinical symptoms (snoring, mouth-breathing, open-mouth posture, malocclusion), and cephalometric measurements (ANB, SNA, SNB angles, and nasopharyngeal soft tissue ratio). Overnight PSG assessed apnea-hypopnea index (AHI), rapid eye movement (REM) sleep proportion, and oxygen saturation. Children were classified as OSA-positive (AHI > 1 event/h) or non-OSA. Statistical analyses included t-tests, ANOVA, Pearson correlations, logistic regression, receiver operating characteristic (ROC) analysis, principal component analysis (PCA), and decision-tree modelling to identify predictors and stratify risk. RESULTS: Among 228 children (mean age 7.4 +/- 2.9 years; 62.7% male), 109 underwent PSG. The OSA group showed significantly higher ANB angles (5.8 degrees +/- 1.9 vs 3.9 degrees +/- 1.4, p < 0.01), increased nasopharyngeal soft tissue ratios (0.72 +/- 0.09 vs 0.59 +/- 0.07, p < 0.001), and elevated BMI compared with non-OSA children. AHI correlated positively with ANB (r = 0.48) and soft tissue ratio (r = 0.62), and negatively with minimum SaO(2) (r = -0.47). Habitual snoring (OR = 4.3), mouth-breathing (OR = 2.6), and incomplete lip closure (OR = 3.1) independently predicted OSA. A combined clinical-cephalometric model achieved an AUC of 0.86. PCA revealed distinct anatomical-functional clusters, and a decision-tree model using ANB > 5 degrees , tissue ratio >/= 0.68, and snoring classified OSA with 82% sensitivity and 78% specificity. CONCLUSION: Pediatric OSA is strongly linked to craniofacial imbalance, adenoidal hypertrophy, and functional symptoms. Cephalometric parameters, particularly ANB angle and nasopharyngeal soft tissue ratio, combined with simple clinical indicators, offer reliable, low-cost screening for early OSA detection where PSG access is limited. CI - (c) 2026 Liu et al. FAU - Liu, Ailiang AU - Liu A AD - Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong, People's Republic of China. FAU - Lu, Qinghua AU - Lu Q AD - Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong, People's Republic of China. FAU - Huang, Xiao AU - Huang X AD - Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong, People's Republic of China. FAU - Li, Hairui AU - Li H AD - Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong, People's Republic of China. FAU - Hou, Zhijiang AU - Hou Z AD - Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong, People's Republic of China. FAU - Lin, Weinan AU - Lin W AD - Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong, People's Republic of China. FAU - Huang, Ting AU - Huang T AD - Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong, People's Republic of China. FAU - Cui, Yunfei AU - Cui Y AD - Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong, People's Republic of China. FAU - Wu, Tao AU - Wu T AD - Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong, People's Republic of China. FAU - Xiao, Yaxin AU - Xiao Y AD - Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong, People's Republic of China. FAU - Patil, Sandip AU - Patil S AUID- ORCID: 0000-0003-2736-9206 AD - Department of Haematology and Oncology, Shenzhen Children's Hospital, Shenzhen, Guangdong, People's Republic of China. AD - Paediatric Research Institute, Shenzhen Children's Hospital, Shenzhen, Guangdong, People's Republic of China. FAU - Yang, Qin AU - Yang Q AUID- ORCID: 0000-0002-4403-0645 AD - Department of Respiratory Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong, People's Republic of China. LA - eng PT - Journal Article DEP - 20260108 PL - New Zealand TA - Nat Sci Sleep JT - Nature and science of sleep JID - 101537767 PMC - PMC12998684 OTO - NOTNLM OT - airway anatomy OT - cephalometric analysis OT - clinical predictors OT - paediatric obstructive sleep apnea OT - polysomnography COIS- The authors have no conflict of interest to declare. EDAT- 2026/03/20 07:10 MHDA- 2026/03/20 07:11 PMCR- 2026/01/08 CRDT- 2026/03/20 04:47 PHST- 2025/10/20 00:00 [received] PHST- 2025/12/14 00:00 [accepted] PHST- 2026/03/20 07:11 [medline] PHST- 2026/03/20 07:10 [pubmed] PHST- 2026/03/20 04:47 [entrez] PHST- 2026/01/08 00:00 [pmc-release] AID - 574045 [pii] AID - 10.2147/NSS.S574045 [doi] PST - epublish SO - Nat Sci Sleep. 2026 Jan 8;18:574045. doi: 10.2147/NSS.S574045. eCollection 2026. PMID- 41858170 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 2692-7691 (Electronic) IS - 2692-7691 (Linking) VI - 189 IP - 3 DP - 2026 Mar TI - Validating Dental Histology for Perinatal Age Estimation Using Human Deciduous Teeth. PG - e70231 LID - 10.1002/ajpa.70231 [doi] LID - e70231 AB - OBJECTIVES: This study tests the accuracy of dental histology for perinatal age estimation using deciduous teeth from modern human infants of known age. We evaluate whether enamel and dentin incremental structures, particularly the Neonatal Line (NNL), can be used to provide a reliable estimate of chronological age. SAMPLES AND METHODS: Seventeen unerupted deciduous teeth from 14 full-term infants (0-164 days old) were analyzed from the Granada identified skeletal collection in Spain. Thin sections were examined under transmitted light and confocal microscopy to identify the NNL, cross-striations, and von Ebner's lines. Daily secretion rates (DSR) were measured across crown and root to calculate crown formation time (CFT) and root formation time (RFT), which were compared with the documented ages at death. RESULTS: Mean enamel DSR was 3.38 mum/day, and mean root dentin DSR was 3.24 mum/day. Enamel DSRs varied between tooth types and crown regions. The NNL was identified in all individuals who survived birth and was absent in one stillbirth, confirming its reliability as an indicator of live birth. Prenatal CFTs fell within ranges reported for full-term gestation, supporting the interpretation that all individuals were born at term. Histologically derived ages differed from recorded ages by an underestimation of 8 to an overestimation of 1 day, with a mean difference of 1 day. CONCLUSIONS: Deciduous dental histology provides an accurate estimate of chronological age for human juveniles in the year after birth. These findings suggest that perinatal age estimates derived from dental histology can be applied in bioarchaeological and forensic contexts. CI - (c) 2026 The Author(s). American Journal of Biological Anthropology published by Wiley Periodicals LLC. FAU - Martirosyan, Ani AU - Martirosyan A AUID- ORCID: 0000-0001-6948-8487 AD - Biological Anthropology Unit, Department of Animal Biology, Plant Biology and Ecology, Faculty of Biosciences, Universitat Autonoma de Barcelona, Barcelona, Spain. AD - Research Group in Biological Anthropology (GREAB), Universitat Autonoma de Barcelona, Barcelona, Spain. FAU - Irurita, Javier AU - Irurita J AUID- ORCID: 0000-0003-1676-9773 AD - Department of Legal Medicine, Toxicology and Physical Anthropology, Universidad de Granada, Granada, Spain. FAU - Malgosa, Assumpcio AU - Malgosa A AD - Biological Anthropology Unit, Department of Animal Biology, Plant Biology and Ecology, Faculty of Biosciences, Universitat Autonoma de Barcelona, Barcelona, Spain. AD - Research Group in Biological Anthropology (GREAB), Universitat Autonoma de Barcelona, Barcelona, Spain. FAU - Molera, Judit AU - Molera J AD - MECAMAT, Universitat de Vic-Universitat Central de Catalunya, Barcelona, Spain. FAU - Mahoney, Patrick AU - Mahoney P AUID- ORCID: 0000-0002-2715-3096 AD - School of Natural Sciences, University of Kent, Canterbury, UK. FAU - Jordana, Xavier AU - Jordana X AUID- ORCID: 0000-0002-6016-6630 AD - Biological Anthropology Unit, Department of Animal Biology, Plant Biology and Ecology, Faculty of Biosciences, Universitat Autonoma de Barcelona, Barcelona, Spain. AD - Tissue Repair and Regeneration Laboratory (TR2Lab), Institut de Recerca i Innovacio en Ciencies de la Vida i de la Salut a la Catalunya Central (IrisCC), Barcelona, Spain. LA - eng GR - PGC2018-096666-B-100/Ministerio de Ciencia, Innovacion y Universidades/ GR - PALARQ23_55/Fundacion Palarq/ GR - 2021 SGR 00186/Generalitat de Catalunya/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Am J Biol Anthropol JT - American journal of biological anthropology JID - 101770171 SB - IM MH - Humans MH - *Tooth, Deciduous/anatomy & histology MH - Infant, Newborn MH - *Age Determination by Teeth/methods MH - Female MH - Infant MH - Dentin/anatomy & histology MH - Male MH - Dental Enamel/anatomy & histology MH - Spain MH - Microscopy, Confocal PMC - PMC13003199 OTO - NOTNLM OT - age estimation OT - crown formation time OT - deciduous teeth OT - dental histology OT - neonatal line COIS- The authors declare no conflicts of interest. EDAT- 2026/03/20 07:10 MHDA- 2026/03/20 07:11 PMCR- 2026/03/20 CRDT- 2026/03/20 03:13 PHST- 2026/02/24 00:00 [revised] PHST- 2025/12/09 00:00 [received] PHST- 2026/03/12 00:00 [accepted] PHST- 2026/03/20 07:11 [medline] PHST- 2026/03/20 07:10 [pubmed] PHST- 2026/03/20 03:13 [entrez] PHST- 2026/03/20 00:00 [pmc-release] AID - AJPA70231 [pii] AID - 10.1002/ajpa.70231 [doi] PST - ppublish SO - Am J Biol Anthropol. 2026 Mar;189(3):e70231. doi: 10.1002/ajpa.70231. PMID- 41857857 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 3 DP - 2026 Mar 18 TI - Effects of fermented versus unfermented red cabbage on symptoms, immune response, inflammatory markers and the gut microbiome in young adults with allergic rhinoconjunctivitis: a randomised controlled trial protocol. PG - e115290 LID - 10.1136/bmjopen-2025-115290 [doi] LID - e115290 AB - INTRODUCTION: Allergic rhinoconjunctivitis (ARC) is a highly prevalent immune-mediated condition associated with substantial symptom burden, impaired quality of life and increased healthcare use. Emerging evidence highlights the role of the gut microbiome in immune regulation and allergic disease. Fermented foods may contain live microbes (when unpasteurised or uncooked) and bioactive postbiotic metabolites that can modulate immune responses. Despite growing interest in dietary strategies targeting the microbiome, no randomised controlled trial has compared fermented versus unfermented red cabbage for ARC. METHODS AND ANALYSES: This single-centre, randomised, controlled trial with a sensory-matched, unfermented cabbage comparator investigates the effects of daily consumption of fermented red cabbage for 8 weeks compared with an unfermented red cabbage control in young adults (18-35 years) with ARC. A total of 158 participants will be randomly assigned (1:1). The primary outcome is change in Total Nose and Eye Symptom Score from baseline to week 8. Secondary outcomes include daily symptoms and medication use captured via mobile ecological momentary assessments, quality of life, psychological well-being, gastrointestinal symptoms, systemic inflammatory markers, total IgE, immune cell profile and metagenomic characterisation of stool samples. A nested qualitative component explores participants' experiences and acceptability of the intervention. Analyses will include mixed-effects models, time-series analyses incorporating daily pollen counts and comprehensive microbiome statistics. Safety outcomes and adverse events will also be assessed. ETHICS AND DISSEMINATION: This study was approved by the Ethics Committee of Charite-Universitatsmedizin Berlin (EA4/043/25) and is conducted in accordance with the Declaration of Helsinki and Good Clinical Practice. Results will be disseminated through peer-reviewed publications, conference presentations and a lay summary provided to participants. Anonymised datasets and analysis scripts will be made available in public repositories, and metagenomic sequencing data will be deposited in an international sequence archive to ensure transparency and reproducibility. TRIAL REGISTRATION NUMBER: DRKS00036475. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Ngoumou, Gonza Balbina AU - Ngoumou GB AUID- ORCID: 0000-0001-6501-732X AD - Charite Competence Center for Traditional and Integrative Medicine (CCCTIM), Charite - Universitatsmedizin Berlin, Berlin, Germany gonza.ngoumou@charite.de. FAU - Ngandeu Schepanski, Steven AU - Ngandeu Schepanski S AUID- ORCID: 0000-0002-7695-1289 AD - Charite Competence Center for Traditional and Integrative Medicine (CCCTIM), Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Blakeslee, Sarah B AU - Blakeslee SB AUID- ORCID: 0000-0003-0471-9576 AD - Charite Competence Center for Traditional and Integrative Medicine (CCCTIM), Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Diedering, Alina AU - Diedering A AD - Charite Competence Center for Traditional and Integrative Medicine (CCCTIM), Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Twal, Emily AU - Twal E AD - Charite Competence Center for Traditional and Integrative Medicine (CCCTIM), Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Raue, Sasha Louise AU - Raue SL AD - Charite Competence Center for Traditional and Integrative Medicine (CCCTIM), Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Schroeder, Maik AU - Schroeder M AD - Charite Competence Center for Traditional and Integrative Medicine (CCCTIM), Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Wicaksono, Wisnu Adi AU - Wicaksono WA AD - Institute of Environmental Biotechnology, Graz University of Technology, Graz, Austria. FAU - Stritter, Wiebke AU - Stritter W AD - Charite Competence Center for Traditional and Integrative Medicine (CCCTIM), Charite - Universitatsmedizin Berlin, Berlin, Germany. FAU - Berg, Gabriele AU - Berg G AD - Institute of Environmental Biotechnology, Graz University of Technology, Graz, Austria. AD - Department of Microbiome Biotechnology, Leibniz Institute for Agricultural Engineering and Bioeconomy, Potsdam, Germany. FAU - Seifert, Georg AU - Seifert G AD - Charite Competence Center for Traditional and Integrative Medicine (CCCTIM), Charite - Universitatsmedizin Berlin, Berlin, Germany. AD - Department of Paediatrics, University of Sao Paulo, Sao Paulo, Brazil. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260318 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Conjunctivitis, Allergic/diet therapy/immunology MH - Young Adult MH - Adult MH - *Gastrointestinal Microbiome MH - Quality of Life MH - Randomized Controlled Trials as Topic MH - Adolescent MH - *Brassica MH - Female MH - Biomarkers/blood MH - Male MH - *Fermented Foods PMC - PMC13007187 OTO - NOTNLM OT - IMMUNOLOGY OT - Microbiota OT - NUTRITION & DIETETICS OT - Randomized Controlled Trial OT - Rhinitis, Allergic COIS- Competing interests: None declared. EDAT- 2026/03/20 07:09 MHDA- 2026/03/20 07:10 PMCR- 2026/03/16 CRDT- 2026/03/20 01:00 PHST- 2026/03/20 07:10 [medline] PHST- 2026/03/20 07:09 [pubmed] PHST- 2026/03/20 01:00 [entrez] PHST- 2026/03/16 00:00 [pmc-release] AID - bmjopen-2025-115290 [pii] AID - 10.1136/bmjopen-2025-115290 [doi] PST - epublish SO - BMJ Open. 2026 Mar 18;16(3):e115290. doi: 10.1136/bmjopen-2025-115290. PMID- 41857684 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Mar 19 TI - Integrating physical, emotional, and social changes to examine their associations with self-efficacy among college students engaging in physical activity. LID - 10.1186/s40359-026-04255-5 [doi] LID - 616 AB - INTRODUCTION: College students face increasing physical and psychological challenges, and the multidimensional association between physical activity and well-being warrants clarification. This study tested an integrative model linking physical activity to perceived physical, emotional, and social relationship changes and self-efficacy, and examined variation by sex and training time. METHODS: A cross-sectional survey was conducted among 1,082 full-time university students in China (inclusion: basic engagement in physical activity; exclusion: major physical or mental illness). Validated questionnaires were used to assess physical activity, self-efficacy, health status, and well-being, together with study-developed subscales for perceived physical, emotional, and social relationship changes. Internal consistency and construct validity were evaluated in the study sample, and the intended measurement structure was supported. Correlation analyses and structural equation modelling (SPSS/AMOS) examined model-based associations and moderation by sex and training time. This study was approved by the institutional ethics committee, and informed consent was obtained from all participants. RESULTS: Perceived physical, emotional, and social relationship changes were positively associated with self-efficacy; perceived emotional changes correlated strongly with perceived physical changes (r = 0.843, p < 0.01). In structural equation modelling, perceived emotional changes were positioned between perceived physical changes and downstream social relationship changes and self-efficacy, consistent with an indirect association pattern. Sex differences were observed for social relationship changes and self-efficacy, and training time moderated selected paths. CONCLUSION: Physical activity-related variables were associated with an interconnected physical-emotional-social pattern linked to self-efficacy, with variation by sex and training time. These findings should be interpreted as model-based associations; longitudinal or experimental studies are needed to establish temporal ordering and causal mechanisms. FAU - Zhang, Xiaomei AU - Zhang X AD - School of Humanities and Social Sciences, Fuzhou University, Fuzhou, 350116, Fujian, China. FAU - Wei, Yaming AU - Wei Y AD - Research Center for Arts and health, Xiamen Humanity Hospital, Xiamen, 361000, Fujian, China. FAU - Song, Yongfan AU - Song Y AD - Department of Physical Education Research, Fuzhou University, No. 2, Wulongjiang North Avenue, Fuzhou, 350116, Fujian, China. t11090@fzu.edu.cn. LA - eng PT - Journal Article DEP - 20260319 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - *Self Efficacy MH - Male MH - Female MH - *Students/psychology MH - Cross-Sectional Studies MH - *Exercise/psychology MH - Universities MH - Young Adult MH - China MH - *Emotions MH - Adult MH - *Interpersonal Relations MH - Adolescent MH - Surveys and Questionnaires MH - Sex Factors MH - Health Status MH - Psychological Well-Being PMC - PMC13123179 OTO - NOTNLM OT - Emotion regulation OT - Exercise duration OT - Physical Activity OT - Self-Efficacy OT - Sex differences OT - Social relationships COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Clinical Ethics Committee of Fuzhou University and was conducted in accordance with the Declaration of Helsinki. This study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki. The research protocol was reviewed and approved by the Clinical Ethics Committee of Fuzhou University. The study posed minimal risk to participants, and all data were collected anonymously to protect participant privacy. All participants provided informed consent prior to their inclusion in the study. They were informed of the study's purpose, procedures, and their right to withdraw at any time without consequence. Consent was obtained voluntarily from each participant, and no incentives were provided that could influence participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/20 07:10 MHDA- 2026/06/27 12:38 PMCR- 2026/03/19 CRDT- 2026/03/20 00:40 PHST- 2025/03/22 00:00 [received] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/06/27 12:38 [medline] PHST- 2026/03/20 07:10 [pubmed] PHST- 2026/03/20 00:40 [entrez] PHST- 2026/03/19 00:00 [pmc-release] AID - 10.1186/s40359-026-04255-5 [pii] AID - 4255 [pii] AID - 10.1186/s40359-026-04255-5 [doi] PST - epublish SO - BMC Psychol. 2026 Mar 19;14(1):616. doi: 10.1186/s40359-026-04255-5. PMID- 41857417 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260920 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 4 DP - 2026 Mar 20 TI - Understanding the impact of growth hormone on ventilatory control stability in children with Prader-Willi syndrome. LID - 10.1007/s00431-026-06857-y [doi] LID - 194 AB - A hallmark of Prader-Willi syndrome (PWS) is hypothalamic-pituitary axis dysfunction, which can result in reduced growth hormone (GH) production. While GH replacement therapy is common in children with PWS, it has also been implicated in the development of obstructive sleep apnoea (OSA) in some children. The mechanisms underlying this development are poorly understood but may be related to alterations in ventilatory control. Our study investigated the impact of GH treatment on ventilatory control stability during sleep in children with PWS. Polysomnographic data pre- and post-GH therapy in 25 children (aged 2mo-18y) were used to assess ventilatory control using a validated method that estimates loop gain (dimensionless ratio) from ventilation changes following spontaneous sighs during sleep. Data were analysed using linear mixed-effects modelling with GH as a fixed effect and participant as a random intercept. Covariates that could impact loop gain including age, obstructive-apnoea hypopnoea index (OAHI) and central apnoea-hypopnoea index (CAHI) were each added separately to the base model in a stepwise, manual forward selection approach. Loop gain was not altered by GH treatment (beta = 0.003, 95% CI: [-0.042, 0.049], p = 0.878, Cohen's d = 0.031). Age, OAHI and CAHI did not alter the impact of GH on loop gain. No difference in sleep or respiratory characteristics were found, however 20% of children developed OSA post-GH. CONCLUSION: Initiation of GH therapy was not associated with a change in loop gain, suggesting that changes in ventilatory control are unlikely to contribute to the development of OSA in children with PWS. WHAT IS KNOWN: * Prader-Willi syndrome is associated with abnormal ventilatory control and increased risk of sleep-disordered breathing. * Growth hormone therapy may influence respiratory physiology but its effect on the stability of ventilatory control (loop gain) remains unclear. WHAT IS NEW: * In this cohort of children with Prader-Willi syndrome, growth hormone therapy did not alter loop gain despite inter-individual variability. * Our findings suggest that any sleep-disordered breathing that emerges following growth hormone therapy is likely driven by mechanisms other than altered loop gain. CI - (c) 2026. The Author(s). FAU - Patoglu, Okkes R AU - Patoglu OR AD - Department of Paediatrics, Monash University, Melbourne, VIC, Australia. FAU - Horne, Rosemary S C AU - Horne RSC AD - Department of Paediatrics, Monash University, Melbourne, VIC, Australia. FAU - Mann, Dwayne L AU - Mann DL AD - School of Electrical Engineering and Computer Science, The University of Queensland, Brisbane, QLD, Australia. FAU - Landry, Shane A AU - Landry SA AD - School of Psychological Sciences, Monash University, Melbourne, VIC, Australia. FAU - Kapur, Nitin AU - Kapur N AD - Department of Paediatric Respiratory and Sleep Medicine, Queensland Children's Hospital, Brisbane, QLD, Australia. AD - Children's Health Queensland Clinical Unit, Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia. FAU - Thambar, Samara AU - Thambar S AD - Department of Paediatric Respiratory and Sleep Medicine, Queensland Children's Hospital, Brisbane, QLD, Australia. FAU - Robinson, Jacob AU - Robinson J AD - Department of Paediatric Respiratory and Sleep Medicine, Queensland Children's Hospital, Brisbane, QLD, Australia. FAU - Davey, Margot J AU - Davey MJ AD - Department of Paediatrics, Monash University, Melbourne, VIC, Australia. AD - Melbourne Children's Sleep Centre, Monash Children's Hospital, Melbourne, VIC, Australia. FAU - Nixon, Gillian M AU - Nixon GM AD - Department of Paediatrics, Monash University, Melbourne, VIC, Australia. AD - Melbourne Children's Sleep Centre, Monash Children's Hospital, Melbourne, VIC, Australia. FAU - Edwards, Bradley A AU - Edwards BA AD - School of Psychological Sciences, Monash University, Melbourne, VIC, Australia. Bradley.Edwards@monash.edu. LA - eng PT - Journal Article DEP - 20260320 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 12629-01-5 (Human Growth Hormone) SB - IM MH - Humans MH - *Prader-Willi Syndrome/drug therapy/physiopathology/complications MH - Polysomnography MH - *Sleep Apnea, Obstructive/etiology/chemically induced/physiopathology MH - Child, Preschool MH - Child MH - *Human Growth Hormone/therapeutic use/adverse effects MH - Female MH - Male MH - Adolescent MH - Infant PMC - PMC13002677 OTO - NOTNLM OT - Loop gain OT - Paediatric OT - Prader-Willi syndrome OT - Sleep OT - Ventilatory control COIS- Declarations. Competing interests: Associate Professor Edwards has received grant funding from Apnimed, Myofunctional Research Company, Fisher and Paykall and Incannex as well as personal fees from EQT Partners outside the current work. All other authors have no conflicts of interest to declare. EDAT- 2026/03/20 07:10 MHDA- 2026/03/20 07:11 PMCR- 2026/03/20 CRDT- 2026/03/20 00:28 PHST- 2025/12/13 00:00 [received] PHST- 2026/03/10 00:00 [accepted] PHST- 2026/02/20 00:00 [revised] PHST- 2026/03/20 07:11 [medline] PHST- 2026/03/20 07:10 [pubmed] PHST- 2026/03/20 00:28 [entrez] PHST- 2026/03/20 00:00 [pmc-release] AID - 10.1007/s00431-026-06857-y [pii] AID - 6857 [pii] AID - 10.1007/s00431-026-06857-y [doi] PST - epublish SO - Eur J Pediatr. 2026 Mar 20;185(4):194. doi: 10.1007/s00431-026-06857-y. PMID- 41857344 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 2047-6310 (Electronic) IS - 2047-6302 (Print) IS - 2047-6302 (Linking) VI - 21 IP - 3 DP - 2026 Mar TI - Pilot Randomised Controlled Trial of the Feasibility and Acceptability of Family-Based Time Limited Eating to Treat Obesity. PG - e70103 LID - 10.1111/ijpo.70103 [doi] AB - BACKGROUND: Time-limited eating (TLE) shows promise as an adult obesity treatment; little is known in paediatrics or families. OBJECTIVE: To assess the feasibility and acceptability of family-based TLE. METHODS: This was a 12 week pilot randomized trial comparing family-based TLE to dietary standard of care (SOC). Families included a child aged 3-9 years and caretaker, both with obesity. TLE received instruction to end eating after the evening meal and otherwise eat ad libitum. SOC received dietary instruction. Primary outcomes, feasibility and acceptability, were measured through retention, intervention burden (i.e., treatment time) and satisfaction surveys. Anthropometrics were measured at baseline and 12 weeks. Between-arm comparisons of BMI percentile above the median (%BMIp50) used mixed effects models to account for family clustering; comparisons of adult BMI and child BMI percentage of the 95th percentile (%BMIp95) used two-sample t-tests. RESULTS: Eighteen families enrolled (10 TLE; 8 SOC). Retention was 94% (100% TLE, 88% SOC). TLE required significantly less total treatment time than SOC [84.3 vs. 140.9 min; p < 0.001]. Satisfaction was high; 89% TLE and 100% SOC would recommend their treatment. Overall, SOC reduced mean %BMIp50 more than TLE (mean difference: -3.9; p = 0.001), with no difference in change in child %BMIp95 between arms (-0.2, p = 0.92), but with SOC reducing parental BMI more than TLE (-1.6, p = 0.002). CONCLUSIONS: Family-based TLE was feasible and acceptable and required less time to implement than SOC, suggesting TLE could be an accessible dietary intervention for families. Fully powered studies are needed to determine BMI efficacy. TRIAL REGISTRATION: ClinicalTrials.gov: NCT05107726. CI - (c) 2026 World Obesity Federation. FAU - Gross, Amy C AU - Gross AC AUID- ORCID: 0000-0003-2809-8460 AD - Center for Pediatric Obesity Medicine, University of Minnesota, Minneapolis, USA. AD - Department of Pediatrics, University of Minnesota, Minneapolis, USA. FAU - Helgeson, Erika S AU - Helgeson ES AD - School of Public Health Division of Biostatistics and Health Data Science, University of Minnesota, Minneapolis, USA. FAU - Wang, Qi AU - Wang Q AD - Clinical and Translational Science Institute, University of Minnesota, Minneapolis, USA. FAU - Chow, Lisa S AU - Chow LS AUID- ORCID: 0000-0002-6210-2307 AD - Department of Medicine, Division of Diabetes, Endocrinology and Metabolism, University of Minnesota, Minneapolis, USA. LA - eng SI - ClinicalTrials.gov/NCT05107726 GR - UL1 TR002494/TR/NCATS NIH HHS/United States GR - UM1 TR004405/TR/NCATS NIH HHS/United States GR - UM1TR004405/National Institutes of Health's National Center for Advancing Translational Sciences/ GR - UL1TR002494/National Institutes of Health's National Center for Advancing Translational Sciences/ PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Pediatr Obes JT - Pediatric obesity JID - 101572033 SB - IM MH - Humans MH - Pilot Projects MH - Female MH - Male MH - Child, Preschool MH - Feasibility Studies MH - Body Mass Index MH - Child MH - *Pediatric Obesity/diet therapy/psychology MH - Treatment Outcome MH - Intermittent Fasting MH - *Feeding Behavior/psychology MH - Patient Satisfaction MH - Patient Acceptance of Health Care MH - Weight Loss PMC - PMC13162054 MID - NIHMS2168005 OTO - NOTNLM OT - family treatment OT - obesity OT - paediatric obesity OT - time limited eating OT - time restricted eating COIS- Conflicts of Interest The authors declare no conflicts of interest. EDAT- 2026/03/20 07:10 MHDA- 2026/03/20 07:11 PMCR- 2026/05/12 CRDT- 2026/03/20 00:26 PHST- 2026/02/24 00:00 [revised] PHST- 2025/11/19 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/03/20 07:11 [medline] PHST- 2026/03/20 07:10 [pubmed] PHST- 2026/03/20 00:26 [entrez] PHST- 2026/05/12 00:00 [pmc-release] AID - 10.1111/ijpo.70103 [doi] PST - ppublish SO - Pediatr Obes. 2026 Mar;21(3):e70103. doi: 10.1111/ijpo.70103. PMID- 41856764 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1447-0756 (Electronic) IS - 1341-8076 (Print) IS - 1341-8076 (Linking) VI - 52 IP - 3 DP - 2026 Mar TI - Anthropometric Measurements to Predict Metabolic Syndrome in Thai Women With Polycystic Ovary Syndrome: A Retrospective Study. PG - e70255 LID - 10.1111/jog.70255 [doi] LID - e70255 AB - AIM: To compare the diagnostic accuracy of seven anthropometric indices for predicting metabolic syndrome (MetS) in Thai women with polycystic ovary syndrome (PCOS). METHODS: Electronic medical records of 1492 women aged 15-45 years who attended Siriraj Hospital during 2015-2024 were retrospectively analyzed. MetS was diagnosed using the International Diabetes Federation 2006 criteria. The indices assessed were a body shape index (ABSI), abdominal volume index (AVI), body adiposity index (BAI), body mass index (BMI), body roundness index (BRI), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR). Discrimination was evaluated by receiver operating characteristic (ROC) analysis with area under the curve (AUC) and 95% CI. Optimal cut-offs were identified using the Youden index. RESULTS: Metabolic syndrome prevalence was 20.8%. AVI, BMI, BRI, and WHtR showed comparable discrimination (AUC 0.84-0.85) and outperformed BAI (AUC 0.79), WHR (AUC 0.78), and ABSI (AUC 0.52). A composite of AVI, BRI, and WHtR did not improve discrimination. A BMI threshold of 25.78 kg/m(2) provided the best overall accuracy (69.6%). A WHtR threshold of 0.53 offered similar clinical utility. CONCLUSIONS: BMI and waist-centered indices demonstrate comparable performance for predicting MetS in Thai women with PCOS. BMI provides the highest overall accuracy and, together with WHtR, can serve as practical first-line triage tools. CI - (c) 2026 The Author(s). Journal of Obstetrics and Gynaecology Research published by John Wiley & Sons Australia, Ltd on behalf of Japan Society of Obstetrics and Gynecology. FAU - Yokyongsakul, Marisa AU - Yokyongsakul M AD - Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. FAU - Humart, Pavarit AU - Humart P AUID- ORCID: 0009-0005-6815-0536 AD - Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. FAU - Techatraisak, Kitirat AU - Techatraisak K AD - Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. FAU - Tanmahasamut, Prasong AU - Tanmahasamut P AD - Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. FAU - Rattanachaiyanont, Manee AU - Rattanachaiyanont M AD - Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. FAU - Indhavivadhana, Suchada AU - Indhavivadhana S AD - Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. FAU - Wongwananuruk, Thanyarat AU - Wongwananuruk T AD - Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. FAU - Chantrapanichkul, Panicha AU - Chantrapanichkul P AD - Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. FAU - Phunyammalee, Matus AU - Phunyammalee M AD - Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. FAU - Madeesukstit, Pornpimol AU - Madeesukstit P AD - Gynecologic Endocrinology Unit, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. LA - eng GR - Faculty of Medicine Siriraj Hospital, Mahidol University/ PT - Journal Article PL - Australia TA - J Obstet Gynaecol Res JT - The journal of obstetrics and gynaecology research JID - 9612761 SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/complications/epidemiology MH - *Metabolic Syndrome/diagnosis/epidemiology MH - Thailand/epidemiology MH - Retrospective Studies MH - Adult MH - Adolescent MH - Young Adult MH - Middle Aged MH - *Anthropometry/methods MH - Body Mass Index MH - Waist-Hip Ratio PMC - PMC13002327 OTO - NOTNLM OT - abdominal volume index OT - anthropometry OT - body roundness index OT - metabolic syndrome OT - polycystic ovary syndrome COIS- The authors declare no conflicts of interest. EDAT- 2026/03/20 00:59 MHDA- 2026/03/20 01:00 PMCR- 2026/03/20 CRDT- 2026/03/19 22:03 PHST- 2026/01/24 00:00 [revised] PHST- 2025/10/25 00:00 [received] PHST- 2026/03/13 00:00 [accepted] PHST- 2026/03/20 01:00 [medline] PHST- 2026/03/20 00:59 [pubmed] PHST- 2026/03/19 22:03 [entrez] PHST- 2026/03/20 00:00 [pmc-release] AID - JOG70255 [pii] AID - 10.1111/jog.70255 [doi] PST - ppublish SO - J Obstet Gynaecol Res. 2026 Mar;52(3):e70255. doi: 10.1111/jog.70255. PMID- 41856320 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 1541-6100 (Electronic) IS - 0022-3166 (Linking) VI - 156 IP - 5 DP - 2026 May TI - Beyond Added Sugar Reduction: A Narrative Review of Policies to Address Nonsugar Sweeteners. PG - 101479 LID - S0022-3166(26)00128-8 [pii] LID - 10.1016/j.tjnut.2026.101479 [doi] AB - This perspective provides policymakers, advocates and researchers with a description of proposed and enacted policies that assist consumers in identifying products with nonsugar sweeteners (NSSs) and/or reduce NSS exposure. Consumption of NSSs is associated with multiple chronic diseases. NSS exposure is increasing as food and beverage manufacturers replace added sugars with NSSs. We conducted a narrative review to identify public policies addressing NSSs, focusing on the United States while also considering the international context. A policy scan identified relevant polices through: 1) review of a United States sweetened beverage policy database, 2) systematic searches of 5 online United States policy databases and PubMed, 3) review of a World Health Organization food policy database, 4) survey of NSS policy experts, and 5) review of policies known to the research team. Searches were conducted between November 2024 and February 2025. We describe a selected subset of identified policies in more detail as illustrative examples based on adequacy of NSS definition, impact, feasibility, equity, and comprehensiveness (extent of products included). We identified 416 proposed or enacted policies and classified them into 9 groups: bans and restrictions on NSS use (n = 26), excise taxes (n = 106), sales taxes (n = 67), food package labels and disclosures (n = 47), healthy retail (n = 2), procurement and nutrition standards (n = 71), Supplemental Nutrition Assistance Program benefit restrictions (n = 54), Special Supplemental Nutrition Program for Women, Infants, and Children nutrition standards (n = 7), restaurant healthy default beverages (n = 34), and marketing restrictions (n = 2). Innovative policy options included banning NSSs in products sold to minors, prohibiting misleading sweetener labeling, closing United States Food and Drug Administration approval loopholes permitting the use of NSSs that may lack adequate and transparent safety data, and restricting NSS advertising on public transportation. We conclude that many options for reducing potential harms from NSSs are available. Public policies with the greatest potential impact are bans or restrictions on use, excise taxes, and front-of-package warnings and disclosures. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Krieger, James W AU - Krieger JW AD - Healthy Food America, Seattle, Washington, United States; Department of Health Systems and Population Health, University of Washington, Seattle, Washington, United States. Electronic address: jkrieger@hfamerica.org. FAU - Davis, Jennie N AU - Davis JN AD - University of California, Institute for Global Nutrition, Davis, CA, United States. FAU - Ng, Shu Wen AU - Ng SW AD - Department of Nutrition, Carolina Population Center, University of North Carolina, Chapel Hill, NC, United States; Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States. FAU - Nguyen, Michelle AU - Nguyen M AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada. FAU - Zimova, Adriana AU - Zimova A AD - Marler Clark, Bainbridge Island, WA, USA. FAU - Hedrick, Valisa E AU - Hedrick VE AD - Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA, United States. FAU - Malik, Vasanti S AU - Malik VS AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Smith Taillie, Lindsey AU - Smith Taillie L AD - Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States. FAU - Sylvetsky, Allison C AU - Sylvetsky AC AD - Department of Nutrition, The University of Rhode Island, Kingston, RI, USA. FAU - Falbe, Jennifer AU - Falbe J AD - Department of Human Ecology, University of California, Davis, Davis, CA, United States. LA - eng PT - Journal Article PT - Review DEP - 20260318 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 RN - 0 (Sweetening Agents) RN - 0 (Non-Nutritive Sweeteners) SB - IM MH - Humans MH - *Nutrition Policy MH - United States MH - *Sweetening Agents MH - *Non-Nutritive Sweeteners OTO - NOTNLM OT - artificial sweeteners OT - consumer education OT - exposure reduction OT - nonsugar sweeteners OT - policy options EDAT- 2026/03/20 00:59 MHDA- 2026/05/09 00:33 CRDT- 2026/03/19 20:14 PHST- 2025/09/02 00:00 [received] PHST- 2026/02/21 00:00 [revised] PHST- 2026/03/10 00:00 [accepted] PHST- 2026/05/09 00:33 [medline] PHST- 2026/03/20 00:59 [pubmed] PHST- 2026/03/19 20:14 [entrez] AID - S0022-3166(26)00128-8 [pii] AID - 10.1016/j.tjnut.2026.101479 [doi] PST - ppublish SO - J Nutr. 2026 May;156(5):101479. doi: 10.1016/j.tjnut.2026.101479. Epub 2026 Mar 18. PMID- 41855641 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 1872-7123 (Electronic) IS - 0165-1781 (Linking) VI - 360 DP - 2026 Jun TI - Longitudinal associations among childhood trauma, oxytocin, and metabolic risk in schizophrenia. PG - 117088 LID - S0165-1781(26)00149-6 [pii] LID - 10.1016/j.psychres.2026.117088 [doi] AB - Childhood trauma has been consistently associated with adverse physical and metabolic outcomes in schizophrenia, yet the neurobiological mechanisms translating early-life adversity into long-term metabolic risk remain unclear. Oxytocin, a stress-sensitive neuropeptide involved in metabolic regulation, may modulate stress-related metabolic vulnerability. In this 24-month prospective cohort study, 90 individuals with schizophrenia receiving stable antipsychotic monotherapy and 60 age- and sex-matched healthy controls underwent assessments of anthropometric measures, metabolic parameters, and plasma oxytocin levels at baseline and follow-up. Metabolic outcomes included Continuous Metabolic Syndrome Severity Scores (cMetS-S) and metabolic syndrome (MetS) incidence, while childhood trauma was assessed using the Childhood Trauma Questionnaire-Short Form with cross-validation interviews. Generalized estimating equations were applied to evaluate longitudinal associations, and moderation analyses tested oxytocin x childhood trauma interactions. Greater childhood trauma exposure was associated with lower plasma oxytocin levels (p = .001), higher body mass index (p < .001), and greater metabolic burden over time (p = .009). At 24-month follow-up, individuals with schizophrenia exhibited higher MetS incidence (p = .043) and higher cMetS-S (p = .006) compared with healthy controls.Lower oxytocin levels predicted increased MetS risk (OR = 0.27, p = .009). Importantly, a significant childhood trauma x oxytocin interaction (OR = 0.95, p = .018) indicated that higher oxytocin levels attenuated trauma-related metabolic deterioration. These findings suggest that oxytocinergic dysregulation may be involved in the association between early-life trauma and metabolic risk in schizophrenia and support oxytocin as a candidate biomarker associated with trauma-related metabolic vulnerability. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Goh, Kah Kheng AU - Goh KK AD - Department of Psychiatry, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei, Taiwan; Graduate School of Criminology, National Taipei University, Taipei, Taiwan. FAU - Chen, Po-Yu AU - Chen PY AD - Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry, Taipei City Psychiatry Center, Taipei, Taiwan. FAU - Chang, Hu-Ming AU - Chang HM AD - Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry, Taipei City Psychiatry Center, Taipei, Taiwan. FAU - Kanahara, Nobuhisa AU - Kanahara N AD - Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, Japan. FAU - Chen, Chenyi AU - Chen C AD - Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Graduate Institute of Injury Prevention and Control, College of Public Health, Taipei Medical University, Taipei, Taiwan; Research Center for Mind, Brain & Learning, National Chengchi University, Taipei, Taiwan. FAU - Cheng, Ming-Hui AU - Cheng MH AD - Department of Psychology, National Cheng Kung University, Tainan, Taiwan. FAU - Yang, Cheng-Ta AU - Yang CT AD - Department of Psychology, National Cheng Kung University, Tainan, Taiwan; Institute of Allied Health Sciences, National Cheng Kung University, Tainan, Taiwan. FAU - Lu, Mong-Liang AU - Lu ML AD - Department of Psychiatry, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Psychiatric Research Center, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Psychiatry, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address: mongliang@hotmail.com. LA - eng PT - Journal Article DEP - 20260310 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 RN - 50-56-6 (Oxytocin) SB - IM MH - Humans MH - *Oxytocin/blood MH - Female MH - *Schizophrenia/blood/epidemiology/metabolism/complications MH - Male MH - *Metabolic Syndrome/epidemiology/blood MH - Longitudinal Studies MH - Adult MH - *Adverse Childhood Experiences MH - Prospective Studies OTO - NOTNLM OT - Body mass index OT - Childhood trauma OT - Metabolic syndrome OT - Oxytocin OT - Schizophrenia COIS- Declaration of competing interest All authors have no conflict of interest to report. EDAT- 2026/03/20 00:59 MHDA- 2026/04/07 00:31 CRDT- 2026/03/19 19:02 PHST- 2025/12/31 00:00 [received] PHST- 2026/03/06 00:00 [revised] PHST- 2026/03/10 00:00 [accepted] PHST- 2026/04/07 00:31 [medline] PHST- 2026/03/20 00:59 [pubmed] PHST- 2026/03/19 19:02 [entrez] AID - S0165-1781(26)00149-6 [pii] AID - 10.1016/j.psychres.2026.117088 [doi] PST - ppublish SO - Psychiatry Res. 2026 Jun;360:117088. doi: 10.1016/j.psychres.2026.117088. Epub 2026 Mar 10. PMID- 41855414 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260902 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Mar 19 TI - Effects of Cash Transfer and Incentive Programs on Service Utilization and Treatment Outcomes Related to Neglected Tropical Diseases and Their Impact on Health and Nutrition in Low- and Middle-Income Countries: Protocol for a Systematic Review. PG - e76450 LID - 10.2196/76450 [doi] LID - e76450 AB - BACKGROUND: Despite a global decreasing trend in neglected tropical diseases (NTDs), progress is not on track to meet the Sustainable Development Goals by 2030. Evidence suggests a positive effect of conditional cash transfer programs on controlling NTDs. However, it remains to be evaluated whether other financial incentive programs exert similar effects on NTD-related service utilization and treatment outcomes in low- and middle-income countries (LMICs). OBJECTIVE: This systematic review aims to evaluate the effects of cash transfer and incentive programs on NTD-related service utilization and treatment outcomes in LMICs; to examine how covariates, program design, and implementation plan influence these outcomes; and to examine how NTD-related service utilization and treatment outcomes influence nutritional status and health in LMICs. METHODS: This review will follow the PICOS (Population, Interventions, Comparators, Outcomes, Study Design) framework. The population of this review will be restricted to adults and children of all ages in LMICs. For intervention selection, we will include any program or policies addressing socioeconomic disadvantage through the provision of cash transfers or incentive programs, including but not limited to in-kind transfers, food vouchers, free medicine vouchers, discount coupons, and microcredit to households or individuals. Eligible comparators will be the population who did not receive any intervention, recipients of interventions from before the intervention, and populations or areas exposed to different levels of intervention coverage. The primary outcomes will be service utilization and treatment outcomes related to any of the 21 NTDs prioritized by the World Health Organization. Studies without any financial incentive intervention will be excluded. Studies available in English between 2000 and 2024 will be searched in databases, including PubMed, Google Scholar, Scopus, Cochrane, Embase, and CINAHL. Screening, data extraction, and risk of bias assessment will be conducted independently by two reviewers, and discrepancies, if any, would be resolved by a third reviewer. Quality assessment will use the Revised Cochrane Risk of Bias for randomized trials (RoB 2), Risk of Bias in Non-Randomized Studies of Interventions (ROBINS-I), the Joanna Briggs Institute (JBI) checklist for cross-sectional studies, and the Critical Appraisal Skills Programme (CASP) tool for qualitative studies. Data synthesis will involve narrative summaries by tables and figures, a meta-analysis will be undertaken, and subgroup analyses will be performed where feasible. RESULTS: This project is supported by the Children's Investment Fund Foundation and was funded in March 2024. As of January 15, 2026, article search and title-abstract screening have been completed, and full-text screening is expected to be completed by February 2026. Findings will then be synthesized and reported by the end of April 2026. CONCLUSIONS: The limitations of the study may include potential language bias and methodological heterogeneity, which may limit the feasibility of meta-analysis. The findings of this review will inform policymakers in developing more effective strategic plans for controlling NTDs in LMICs. CI - (c) S M Tafsir Hasan, Radhika Dayal, Amena Al Nishan, Sunetra Ghatak, Puja Chakraborty, Sudeshna Maitra, Sumaiya Tasneem Raisa, Nizamuddin Khan, Dinesh Mondal, Tahmeed Ahmed, Avishek Hazra. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Hasan, S M Tafsir AU - Hasan SMT AUID- ORCID: 0000-0002-6062-4072 AD - International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh, 880 1709651470. FAU - Dayal, Radhika AU - Dayal R AUID- ORCID: 0000-0002-1262-6612 AD - PopulationCouncil Consulting Private Limited, Noida, Uttar Pradesh, India. FAU - Nishan, Amena Al AU - Nishan AA AUID- ORCID: 0000-0002-7367-858X AD - International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh, 880 1709651470. FAU - Ghatak, Sunetra AU - Ghatak S AUID- ORCID: 0000-0001-9320-0498 AD - PopulationCouncil Consulting Private Limited, Noida, Uttar Pradesh, India. AD - O. P. Jindal Global University, Sonipat, Haryana, India. FAU - Chakraborty, Puja AU - Chakraborty P AUID- ORCID: 0009-0007-2293-7258 AD - International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh, 880 1709651470. FAU - Maitra, Sudeshna AU - Maitra S AUID- ORCID: 0000-0002-6931-8063 AD - PopulationCouncil Consulting Private Limited, Noida, Uttar Pradesh, India. FAU - Raisa, Sumaiya Tasneem AU - Raisa ST AUID- ORCID: 0009-0006-4961-4486 AD - International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh, 880 1709651470. FAU - Khan, Nizamuddin AU - Khan N AUID- ORCID: 0000-0001-9781-6249 AD - PopulationCouncil Consulting Private Limited, Noida, Uttar Pradesh, India. FAU - Mondal, Dinesh AU - Mondal D AUID- ORCID: 0000-0001-9154-8327 AD - International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh, 880 1709651470. FAU - Ahmed, Tahmeed AU - Ahmed T AUID- ORCID: 0000-0002-4607-7439 AD - International Centre for Diarrhoeal Disease Research Bangladesh (icddr,b), 68, Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh, 880 1709651470. FAU - Hazra, Avishek AU - Hazra A AUID- ORCID: 0000-0001-5992-189X AD - PopulationCouncil Consulting Private Limited, Noida, Uttar Pradesh, India. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260319 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - *Neglected Diseases/economics/therapy MH - Developing Countries/economics/statistics & numerical data MH - *Tropical Medicine/economics/methods MH - Systematic Reviews as Topic MH - *Motivation MH - Treatment Outcome MH - Nutritional Status PMC - PMC13006489 OTO - NOTNLM OT - cash transfer OT - health OT - incentive program OT - low- and middle-income countries OT - neglected tropical disease OT - nutrition OT - service utilization OT - treatment outcome COIS- Conflicts of Interest: None declared. EDAT- 2026/03/19 21:43 MHDA- 2026/03/19 21:44 PMCR- 2026/03/19 CRDT- 2026/03/19 15:32 PHST- 2025/05/04 00:00 [received] PHST- 2026/01/25 00:00 [revised] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/03/19 21:44 [medline] PHST- 2026/03/19 21:43 [pubmed] PHST- 2026/03/19 15:32 [entrez] PHST- 2026/03/19 00:00 [pmc-release] AID - v15i1e76450 [pii] AID - 76450 [pii] AID - 10.2196/76450 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Mar 19;15:e76450. doi: 10.2196/76450. PMID- 41854913 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1432-0711 (Electronic) IS - 0932-0067 (Print) IS - 0932-0067 (Linking) VI - 313 IP - 1 DP - 2026 Mar 19 TI - Aortic isthmus Doppler hemodynamics and impacts on perinatal outcomes in pregestational and gestational diabetes mellitus. LID - 10.1007/s00404-026-08378-3 [doi] LID - 133 AB - BACKGROUND/AIM: To assess the sensitivity of the fetal aortic isthmus (AoI) Doppler changes in predicting the adverse perinatal outcome with pregestational and gestational diabetes mellitus compared with other Doppler parameters. MATERIALS AND METHODS: This prospective case-control study was undertaken between Agust 2023 and May 2024 in Ankara Etlik City Hospital perinatology department. Maternal age, gravidity, parity, maternal body mass index (BMI), gestational age at ultrasonographic examination, fetal AoI, umbilical artery (UA), middle cerebral artery (MCA), and uterine artery (UtA) Doppler parameters were compared between four groups: Pregestational diabetes mellitus (PGDM) (n = 30), diet-regulated gestational diabetes mellitus (DRGDM) (n = 30), insulin-regulated GDM (IRGDM) (n = 30), and controls (n = 75). HbA1c values were evaluated only in pregnancies complicated by diabetes mellitus. The composite adverse perinatal outcomes (CAPO) was defined as Apgar score at 5 min < 7, cord blood pH < 7, sepsis, phototherapy for neonates, respiratory distress syndrome (RDS), mechanical ventilation, neonatal intensive care unit (NICU) admission, hypoglycemia. RESULTS: Maternal age and BMI levels were significantly higher in the PGDM group (p < 0.001). HbA1c levels were significantly higher in the PGDM group compared to other diabetic groups (p < 0.001). While most Doppler parameters were similar across groups, PGDM cases had higher rates of prematurity (40%), cesarean delivery (90%), NICU admission (60%), and CAPO (63.3%) compared to controls (p < 0.01 for all). HbA1c was positively correlated with MCA S/D, AoI-PSV, and AoI S/D (p < 0.05). ROC analysis showed that AoI Ta-max and EDV had modest predictive value for CAPO (AUC = 0.627 and 0.638, respectively; p < 0.05). CONCLUSIONS: The AoI Doppler flow measurements may serve as a potential adjunctive marker in the assessment of adverse perinatal outcomes in pregnancies complicated by diabetes mellitus. However, further large-scale prospective studies are warranted to validate its clinical applicability and establish its role in routine obstetric practice. CI - (c) 2026. The Author(s). FAU - Seyhanli, Zeynep AU - Seyhanli Z AUID- ORCID: 0000-0003-3924-3723 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. drzeynepseyhanli@gmail.com. FAU - Karabay, Gulsan AU - Karabay G AUID- ORCID: 0000-0003-2567-2850 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Filiz, Ahmet Arif AU - Filiz AA AUID- ORCID: 0000-0002-6137-0270 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Duygulu Bulan, Dilara AU - Duygulu Bulan D AUID- ORCID: 0000-0001-9983-2306 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Agaoglu, Recep Taha AU - Agaoglu RT AUID- ORCID: 0000-0002-6570-1006 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Aktemur, Gizem AU - Aktemur G AUID- ORCID: 0000-0001-6824-881X AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Cakir, Betul Tokgoz AU - Cakir BT AUID- ORCID: 0000-0003-0202-4981 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Yucel, Kadriye Yakut AU - Yucel KY AUID- ORCID: 0000-0003-3182-4312 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Yilmaz, Zehra Vural AU - Yilmaz ZV AUID- ORCID: 0000-0002-8719-1879 AD - Department of Obstetrics and Gynecology, Division of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260319 PL - Germany TA - Arch Gynecol Obstet JT - Archives of gynecology and obstetrics JID - 8710213 SB - IM MH - Humans MH - Pregnancy MH - Female MH - *Diabetes, Gestational/physiopathology/diagnostic imaging MH - Case-Control Studies MH - Prospective Studies MH - *Ultrasonography, Prenatal/methods MH - Pregnancy Outcome MH - Ultrasonography, Doppler MH - Umbilical Arteries/diagnostic imaging MH - Adult MH - Uterine Artery/diagnostic imaging MH - *Aorta, Thoracic/diagnostic imaging/physiopathology/embryology MH - Middle Cerebral Artery/diagnostic imaging MH - Hemodynamics MH - Infant, Newborn MH - *Pregnancy in Diabetics/physiopathology PMC - PMC13002718 OTO - NOTNLM OT - Aortic isthmus OT - Composite adverse perinatal outcomes OT - Doppler OT - Gestational diabetes mellitus COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: Written informed consent was obtained from all participants prior to their enrollment in the study. The research was conducted in adherence to the guidelines outlined in the Declaration of Helsinki. The Ethics Committee of Ankara Etlik City Hospital granted approval (Number: AESH-EK1-2023-358). EDAT- 2026/03/19 21:44 MHDA- 2026/03/19 21:45 PMCR- 2026/03/19 CRDT- 2026/03/19 12:15 PHST- 2025/11/19 00:00 [received] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/03/19 21:45 [medline] PHST- 2026/03/19 21:44 [pubmed] PHST- 2026/03/19 12:15 [entrez] PHST- 2026/03/19 00:00 [pmc-release] AID - 10.1007/s00404-026-08378-3 [pii] AID - 8378 [pii] AID - 10.1007/s00404-026-08378-3 [doi] PST - epublish SO - Arch Gynecol Obstet. 2026 Mar 19;313(1):133. doi: 10.1007/s00404-026-08378-3. PMID- 41854621 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260930 IS - 2168-619X (Electronic) IS - 2168-6181 (Print) IS - 2168-6181 (Linking) VI - 152 IP - 5 DP - 2026 May 1 TI - Tumor and Flap Reconstruction Volumes and Functional Outcomes after Glossectomy. PG - 513-522 LID - 10.1001/jamaoto.2026.0099 [doi] AB - IMPORTANCE: Oral tongue is the most common subsite of oral cavity cancers, and incidence is increasing. Tongue resection is associated with morbidity, affecting speech, swallowing, and quality of life. OBJECTIVE: To assess the association of tumor volume and extent of tongue resection with functional outcomes. DESIGN, SETTING, AND PARTICIPANTS: Patients with squamous cell carcinoma who underwent surgical resection of the oral tongue at a tertiary-level academic institution between 2014 and 2025 were included in this retrospective cohort study. Demographic, tumor, treatment, and postoperative outcomes measured with validated instruments were identified. EXPOSURE: Partial or hemiglossectomy (PG) vs total or subtotal glossectomy (TG). MAIN OUTCOMES AND MEASURES: Functional Oral Intake Scale (FOIS) score of 3 or lower, indicating gastrostomy tube dependency. Multivariable analysis assessed risk factors for the primary outcome. Radiographic volumetric analysis of tumor, tongue, and flap volumes was performed. Linear and nonlinear regression modeling assessed the association between measured volumes and functional outcomes. RESULTS: Of 357 patients (median age 62.3 [range, 18-95] years; 51.0% female), 88.2% [n=315] had PG and 11.8% [n=42] had TG. Tumors were classified as T1 or T2 in 71.2% of patients (254 of 357) and as T3 or T4 in 28.8% (103 of 357). Free-flap reconstruction was performed in 150 (42.0%) patients, and 186 (52.1%) received adjuvant radiation. Median follow-up was 36.1 (IQR, 18.2-65.6) months. The TG cohort had worse median FOIS score (2 [IQR, 1-5] vs 5 [IQR, 4-6]), aspiration (3 [IQR, 2-5] vs 1 [IQR, 1-2]), tongue strength (17 [IQR, 15-20] vs 36 [IQR, 25-42]), tongue range of motion (16 [IQR, 0-25] vs 88 [IQR, 63-100]), speech understandability (50 [IQR, 50-75] vs 100 [IQR, 100-100]), and patient-reported quality of life (67 [IQR, 60-71] vs 77 [IQR, 65-86]). On multivariable analysis, older age, current or former smoking status, use of free flap, TG, and greater resection volume were associated with FOIS score of 3 or lower. Preoperative tumor fraction greater than 31% and resection volume fraction greater than 67% were associated with the outcome of FOIS score of 3 or lower, indicating gastrostomy tube dependence. Preoperative tumor fraction greater than 26% and resection volume fraction greater than 58% were associated with understandability of speech score lower than 75, indicating poorly intelligible speech. On nonlinear regression analysis, tongue volume restoration to 100% of baseline value was associated with improved oral intake. CONCLUSIONS AND RELEVANCE: In this study, volumetric analysis demonstrated that tumor, resection, flap, and total tongue volumes were associated with speech and swallow outcomes. These findings suggest that quantitative knowledge of incremental changes in tongue resection and restoration may contribute to improved preoperative counseling and functional outcomes. FAU - Wu, Shannon S AU - Wu SS AD - Division of Head and Neck Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California. FAU - Jetly, Anushka S AU - Jetly AS AD - Stanford University School of Medicine, Palo Alto, California. FAU - Starmer, Heather M AU - Starmer HM AD - Division of Head and Neck Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California. FAU - Finegersh, Andrey AU - Finegersh A AD - Division of Head and Neck Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California. FAU - Holsinger, F Christopher AU - Holsinger FC AD - Division of Head and Neck Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California. FAU - Chen, Michelle M AU - Chen MM AD - Division of Head and Neck Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California. FAU - Divi, Vasu AU - Divi V AD - Division of Head and Neck Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California. FAU - Pham, Nancy AU - Pham N AD - Division of Neuroimaging and Neurointervention, Stanford University School of Medicine, Palo Alto, California. FAU - Baik, Fred M AU - Baik FM AD - Division of Head and Neck Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Palo Alto, California. LA - eng PT - Journal Article PL - United States TA - JAMA Otolaryngol Head Neck Surg JT - JAMA otolaryngology-- head & neck surgery JID - 101589542 SB - IM MH - Humans MH - *Glossectomy/methods MH - Female MH - Retrospective Studies MH - *Tongue Neoplasms/surgery/pathology/physiopathology MH - Middle Aged MH - Aged MH - Male MH - Adult MH - Aged, 80 and over MH - *Surgical Flaps MH - *Carcinoma, Squamous Cell/surgery/pathology MH - *Plastic Surgery Procedures/methods MH - Adolescent MH - Young Adult MH - Tumor Burden MH - Treatment Outcome MH - Quality of Life PMC - PMC13003403 COIS- Conflict of Interest Disclosures: Dr Divi reported receiving personal fees from Regeneron and personal fees from Replimune outside the submitted work. No other disclosures were reported. EDAT- 2026/03/19 15:13 MHDA- 2026/05/14 14:49 PMCR- 2027/03/19 CRDT- 2026/03/19 11:34 PHST- 2026/05/14 14:49 [medline] PHST- 2026/03/19 15:13 [pubmed] PHST- 2026/03/19 11:34 [entrez] PHST- 2027/03/19 00:00 [pmc-release] AID - 2846029 [pii] AID - ooi260009 [pii] AID - 10.1001/jamaoto.2026.0099 [doi] PST - ppublish SO - JAMA Otolaryngol Head Neck Surg. 2026 May 1;152(5):513-522. doi: 10.1001/jamaoto.2026.0099. PMID- 41854388 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1746-1561 (Electronic) IS - 0022-4391 (Print) IS - 0022-4391 (Linking) VI - 96 IP - 4 DP - 2026 Apr TI - Classroom-Integrated Kettlebell Training: Effects on Motor Performance, Attention, and Health in Primary School Children. PG - e70136 LID - 10.1111/josh.70136 [doi] LID - e70136 AB - BACKGROUND: Declining physical fitness and rising obesity in children call for effective interventions. Integrating kettlebell training into the classroom may provide a practical way to overcome existing barriers. This study examined its feasibility and effectiveness on second graders' motor performance, attention, and health. METHODS: Three classes (pre n = 61; post n = 47) performed daily 15-min kettlebell training for 7 weeks, while two classes (pre n = 33; post n = 31) served as controls. Pre/post assessments included mid-thigh pull, grip strength, countermovement jump, sprint, shuttle run, eye-hand coordination, side hop test, Flanker task, body composition, and blood pressure. Linear mixed models analyzed group differences, reporting Cohen's d and 95% confidence intervals (CIs). RESULTS: Small effects were observed in sprint (p = 0.01, d = 0.46, 95% CI [0.20-0.73], Delta = +3.6% [1.5-5.6]) and mid-thigh pull (p = 0.14, d = 0.28 [-0.08 to 0.64], Delta = +5.5% [-1.7 to 12.6]). IMPLICATIONS FOR SCHOOL HEALTH POLICY, PRACTICE, AND EQUITY: Fun, safe, and regular sessions with simple routines and age-appropriate exercises are required. CONCLUSION: This classroom-integrated program is feasible and effective, particularly for enhancing lower-body strength and promoting movement during the school day. TRIAL REGISTRATION: NCT06910085. CI - (c) 2026 The Author(s). Journal of School Health published by Wiley Periodicals LLC on behalf of American School Health Association. FAU - Braun, Nicole AU - Braun N AUID- ORCID: 0009-0004-7039-9341 AD - Department of Sports, Exercise and Health, University of Basel, Basel, Switzerland. FAU - Ledergerber, Romina AU - Ledergerber R AUID- ORCID: 0000-0003-1505-1188 AD - Department of Sports, Exercise and Health, University of Basel, Basel, Switzerland. FAU - Lichtenstein, Eric AU - Lichtenstein E AD - Department of Sports, Exercise and Health, University of Basel, Basel, Switzerland. FAU - Nebiker, Lukas AU - Nebiker L AD - Department of Sports, Exercise and Health, University of Basel, Basel, Switzerland. FAU - Roth, Ralf AU - Roth R AUID- ORCID: 0000-0002-3029-6004 AD - Department of Sports, Exercise and Health, University of Basel, Basel, Switzerland. LA - eng SI - ClinicalTrials.gov/NCT06910085 GR - Starak/ PT - Clinical Study PT - Journal Article PL - United States TA - J Sch Health JT - The Journal of school health JID - 0376370 SB - IM MH - Child MH - Female MH - Humans MH - Male MH - *Attention/physiology MH - Feasibility Studies MH - *Motor Skills/physiology MH - *Physical Education and Training/methods MH - *Physical Fitness/physiology MH - Schools PMC - PMC13001634 OTO - NOTNLM OT - pediatric health OT - school-based program OT - strength training COIS- The authors declare no conflicts of interest. EDAT- 2026/03/19 15:13 MHDA- 2026/03/19 15:14 PMCR- 2026/03/19 CRDT- 2026/03/19 09:52 PHST- 2026/01/16 00:00 [revised] PHST- 2025/08/19 00:00 [received] PHST- 2026/02/26 00:00 [accepted] PHST- 2026/03/19 15:14 [medline] PHST- 2026/03/19 15:13 [pubmed] PHST- 2026/03/19 09:52 [entrez] PHST- 2026/03/19 00:00 [pmc-release] AID - JOSH70136 [pii] AID - 10.1111/josh.70136 [doi] PST - ppublish SO - J Sch Health. 2026 Apr;96(4):e70136. doi: 10.1111/josh.70136. PMID- 41852676 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260319 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Nutrition literacy among primary school students in Nanshan District, Shenzhen: current status and influencing factors. PG - 1775403 LID - 10.3389/fnut.2026.1775403 [doi] LID - 1775403 AB - OBJECTIVE: Nutrition literacy is critical for establishing healthy dietary behaviors during childhood, yet research on this topic among primary school students in rapidly urbanizing China remains limited. The aim of this large-scale survey is to assess the current status and identify key influencing factors of nutrition literacy among primary school students in Nanshan District, Shenzhen City. METHODS: A cross-sectional survey was conducted in October 2024 utilizing a cluster random sampling method. A total of 2,423 students from 21 public primary schools participated. Data were collected using the validated "Nutrition Literacy and Dietary Behavior Questionnaire for School-aged Children", which evaluated four dimensions: nutrition knowledge and concepts, food selection, food preparation, and food intake. Statistical analyses included descriptive statistics, correlation analysis, and binary logistic regression. RESULTS: Participants achieved a mean total nutrition literacy score of 69.93 +/- 8.75, with 30.38% meeting the criterion for adequate nutrition literacy (score >/=75). Interdimensional analysis revealed statistically significant positive correlations among all four domains (r = 0.198 ~ 0.363, p < 0.001). Multivariable logistic regression identified grade level-representing individual-level factors (Grade 5 vs. Grade 3 OR = 0.626, 95% CI: 0.500-0.783), high household economic status-family-level factors (OR = 1.389, 95% CI: 1.139-1.649), and participation in school activities including nutrition-related activities (OR = 1.346, 95% CI: 1.125-1.611) and regular weight monitoring (OR = 1.346, 95% CI: 1.125-1.611) as key predictors of adequate nutrition literacy. CONCLUSION: Nutrition literacy among primary school students in Nanshan District requires substantial improvement and is influenced by factors at individual, familial, and institutional levels. These findings suggest the necessity of developing a comprehensive, student-centered intervention model that integrates family-school collaboration to effectively enhance nutritional literacy. CI - Copyright (c) 2026 Yang, Li, Zhang, Li, Zheng and Zhu. FAU - Yang, Jing AU - Yang J AD - Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China. FAU - Li, Nana AU - Li N AD - School of Public Health, Zunyi Medical University, Zunyi, China. FAU - Zhang, Ti AU - Zhang T AD - Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China. FAU - Li, Xiaoyue AU - Li X AD - Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China. FAU - Zheng, Liuyuan AU - Zheng L AD - Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China. FAU - Zhu, Minmin AU - Zhu M AD - Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen, China. LA - eng PT - Journal Article DEP - 20260303 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12992053 OTO - NOTNLM OT - Shenzhen OT - health literacy OT - influencing factors OT - nutrition literacy OT - primary school students COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/19 07:10 MHDA- 2026/03/19 07:11 PMCR- 2026/03/03 CRDT- 2026/03/19 04:57 PHST- 2025/12/25 00:00 [received] PHST- 2026/02/13 00:00 [revised] PHST- 2026/02/19 00:00 [accepted] PHST- 2026/03/19 07:11 [medline] PHST- 2026/03/19 07:10 [pubmed] PHST- 2026/03/19 04:57 [entrez] PHST- 2026/03/03 00:00 [pmc-release] AID - 10.3389/fnut.2026.1775403 [doi] PST - epublish SO - Front Nutr. 2026 Mar 3;13:1775403. doi: 10.3389/fnut.2026.1775403. eCollection 2026. PMID- 41852354 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260319 LR - 20260813 IS - 2666-7762 (Electronic) IS - 2666-7762 (Linking) VI - 65 DP - 2026 Jun TI - Alignment of physical education curricula with physical literacy across Europe: an observational mapping study with country-level predictors. PG - 101641 LID - 10.1016/j.lanepe.2026.101641 [doi] LID - 101641 AB - BACKGROUND: Physical literacy (PL) is recognised by UNESCO and WHO for fostering lifelong physical activity. Although PL stands on the global agenda of health and education policies, analyses of the adoption by European education are scant. This study aimed to map the alignment of physical education with PL in Europe, explore potential predictors at country level, and identify country 'alignment laggards'. METHODS: Experts from 40 European countries assessed the alignment of national physical education curricula with PL using a pre-validated 15-indicator survey (alpha = 0.86). Country-level PL alignment scores were calculated and mapped. Regression models investigated whether these scores were predicted by educational attainment (PISA), human development (Human Development Index), relative economic strength (Gross Domestic Product/Capita), societal liberty (Human Freedom Index), and innovation spirit (Global Innovation Index). Residual errors were computed to identify association-adjusted 'laggards' in curricular PL alignment. FINDINGS: Significant heterogeneity in PL alignment existed across Europe. Estonia, Wales, Finland, and Norway showed the highest, and Romania, Croatia, Cyprus, and England the lowest PL alignment. Countries' educational attainment (beta = 0.43 [CI(95) 0.13, 0.65], p = 0.0062), human development (beta = 0.32 [CI(95) 0.011, 0.58], p = 0.043), and innovation spirit (beta = 0.32 [CI(95) 0.0071, 0.58], p = 0.046) were significantly associated with curricular PL alignment but not relative economic strength and liberty. A total of 17 European countries were consistent 'laggards' in curricular PL alignment across all significant predictors. INTERPRETATION: PL policies follow educational, developmental, and innovative gradients. Stakeholders should integrate PL as a strategic lever to transform physical education, guiding curricula and programmes to foster health through lifelong physical activity. FUNDING: None. CI - (c) 2026 The Author(s). FAU - Carl, Johannes AU - Carl J AD - Deakin University, Institute for Physical Activity and Nutrition, School of Health and Social Development, Geelong, VIC, Australia. FAU - Salin, Kasper AU - Salin K AD - University of Jyvaskyla, Faculty of Sport and Health Sciences, Jyvaskyla, Finland. FAU - Barnett, Lisa M AU - Barnett LM AD - Deakin University, Institute for Physical Activity and Nutrition, School of Health and Social Development, Geelong, VIC, Australia. FAU - Foweather, Lawrence AU - Foweather L AD - Liverpool John Moores University, Research Institute for Sport and Exercise Sciences, Liverpool (Merseyside), England, United Kingdom. FAU - Jurak, Gregor AU - Jurak G AD - University of Ljubljana, Faculty of Sport, Ljubljana, Slovenia. FAU - Martins, Joao AU - Martins J AD - Universidade de Lisboa, Instituto de Educacao, UIDEF e Faculdade de Motricidade Humana, Lisboa, Portugal. FAU - Muller, Ivan AU - Muller I AD - Department of Sport, Exercise and Health, University of Basel, Basel, Switzerland. FAU - O'Brien, Wesley AU - O'Brien W AD - University College Cork, Physical Education, Sports Studies and Arts Programme, Cork, Ireland. FAU - Venetsanou, Fotini AU - Venetsanou F AD - National and Kapodistrian University of Athens, School of Physical Education and Sport Science, Dafni/Athens, Greece. FAU - Singh, Amika AU - Singh A AD - Mulier Institute, Utrecht, Netherlands. AD - Windesheim University of Applied Sciences, Zwolle, Netherlands. FAU - Elsborg, Peter AU - Elsborg P AD - Frederiksberg Hospital, Center for Clinical Research and Prevention, Frederiksberg, Denmark. FAU - Goss, Hannah AU - Goss H AD - Dublin City University, School of Health and Human Performance, Dublin, Ireland. FAU - Lundvall, Suzanne AU - Lundvall S AD - Department of Food and Nutrition and Sport Science, University of Gothenburg, Gothenburg, Sweden. AD - Department of Sport, Food and Natural Sciences, Western Norway University of Applied Sciences (HVL), Sogndal, Norway. FAU - Pavlova, Iuliia AU - Pavlova I AD - Department of Theory and Methods of Physical Culture, Ivan Boberskyj Lviv State University of Physical Culture, Lviv, Ukraine. FAU - D'Anna, Cristiana AU - D'Anna C AD - Department of Psychology and Education, Pegaso University, Naples, Italy. FAU - Vlcek, Petr AU - Vlcek P AD - Goethe University Frankfurt, Institute of Sports Sciences, Frankfurt am Main, Germany. CN - EUROPLIT group LA - eng PT - Journal Article DEP - 20260310 PL - England TA - Lancet Reg Health Eur JT - The Lancet regional health. Europe JID - 101777707 PMC - PMC12994078 OTO - NOTNLM OT - Children OT - Curriculum OT - Exercise OT - Physical activity OT - Schools OT - Teaching OT - Wellbeing COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. FIR - Alguren, Beatrix IR - Alguren B FIR - Antala, Branislav IR - Antala B FIR - Bartle, Gillian IR - Bartle G FIR - Birch, Jens IR - Birch J FIR - Bryant, Anna IR - Bryant A FIR - Carlos-Vivas, Jorge IR - Carlos-Vivas J FIR - Christodoulides, Efstathios IR - Christodoulides E FIR - Cowley, Joe G IR - Cowley JG FIR - Csanyi, Tamas IR - Csanyi T FIR - De Martelaer, Kristine IR - De Martelaer K FIR - Emeljanovas, Arunas IR - Emeljanovas A FIR - Eren, Gonca IR - Eren G FIR - Fernate, Andra IR - Fernate A FIR - Gilic, Barbara IR - Gilic B FIR - Gisladottir, Thordis IR - Gisladottir T FIR - Green, Nigel IR - Green N FIR - Groffik, Dorota IR - Groffik D FIR - Heck, Sandra IR - Heck S FIR - van Hilvoorde, Ivo IR - van Hilvoorde I FIR - Huhtiniemi, Mikko IR - Huhtiniemi M FIR - Iconomescu, Teodora-Mihaela IR - Iconomescu TM FIR - Jaunig, Johannes IR - Jaunig J FIR - Jones, Ellen IR - Jones E FIR - Kelso, Anne IR - Kelso A FIR - Koka, Andre IR - Koka A FIR - Kreinbucher-Bekerle, Christoph IR - Kreinbucher-Bekerle C FIR - Laudanska-Krzeminska, Ida IR - Laudanska-Krzeminska I FIR - Masanovic, Bojan IR - Masanovic B FIR - McFlynn, Paul IR - McFlynn P FIR - McKee, Melanie IR - McKee M FIR - Mendoza-Munoz, Maria IR - Mendoza-Munoz M FIR - Melby, Paulina S IR - Melby PS FIR - Mieziene, Brigita IR - Mieziene B FIR - Milanovic, Ivana IR - Milanovic I FIR - Mileva, Eleonora IR - Mileva E FIR - Mouton, Alexandre IR - Mouton A FIR - Nemeth, Zsolt IR - Nemeth Z FIR - Olaru, Bogdan Sorin IR - Olaru BS FIR - Onofre, Marcos IR - Onofre M FIR - Petrytsa, Petro IR - Petrytsa P FIR - Pihu, Maret IR - Pihu M FIR - Popeska, Biljana IR - Popeska B FIR - Popovic, Stevo IR - Popovic S FIR - Poweleit, Andre IR - Poweleit A FIR - Janic, Snezana Radisavljevic IR - Janic SR FIR - Riga, Vassiliki IR - Riga V FIR - Schnitzler, Christophe IR - Schnitzler C FIR - Sekulic, Damir IR - Sekulic D FIR - Semyonova, Marina IR - Semyonova M FIR - Smila, Baiba IR - Smila B FIR - Topfer, Clemens IR - Topfer C FIR - Tsivitanidou, Olia IR - Tsivitanidou O FIR - Vasickova, Jana IR - Vasickova J FIR - Winje, Oystein IR - Winje O FIR - Zito, Viviana IR - Zito V FIR - Yildizer, Gunay IR - Yildizer G EDAT- 2026/03/19 07:11 MHDA- 2026/03/19 07:12 PMCR- 2026/03/10 CRDT- 2026/03/19 04:53 PHST- 2025/10/06 00:00 [received] PHST- 2026/02/19 00:00 [revised] PHST- 2026/02/20 00:00 [accepted] PHST- 2026/03/19 07:12 [medline] PHST- 2026/03/19 07:11 [pubmed] PHST- 2026/03/19 04:53 [entrez] PHST- 2026/03/10 00:00 [pmc-release] AID - S2666-7762(26)00053-0 [pii] AID - 101641 [pii] AID - 10.1016/j.lanepe.2026.101641 [doi] PST - epublish SO - Lancet Reg Health Eur. 2026 Mar 10;65:101641. doi: 10.1016/j.lanepe.2026.101641. eCollection 2026 Jun. PMID- 41851929 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 1999-6217 (Electronic) IS - 1727-5482 (Linking) VI - 23 IP - 3 DP - 2026 Jan 26 TI - Prevalence and Risk Factors of Myopia among Undergraduate Students. PG - 457-466 LID - 10.33314/jnhrc.v23i03.4653 [doi] AB - BACKGROUND: This study aims to determine the prevalence of refractive error among undergraduate students in Far Western Nepal and association with ethnicity, parental history of myopia and environmental factors. METHODS: Non-interventional, cross-sectional study was done with random sampling involving 768 undergraduate students aged 18 to 26 years were included. Comprehensive ocular examinations were performed using non-cycloplegic refraction by single examiner. A structured, pre-validated questionnaire was used to gather personal demographics, outdoor activity levels, screen time, parental history of myopia, and ethnicity. RESULTS: The refractive error was found in 16.63% with myopia prevalent in 16.40% of the students. The findings revealed a significant association between myopia and several risk factors, including parental myopia (?=-0.86+/-0.05; p<0.001), extended near work (?=-0.60+/-0.08; p<0.001), and high screen time (?=-0.81+/-0.05; p<0.001). This significant association revealed higher incidences of myopia within academic departments that require intensive near visual tasks, especially in engineering department. Furthermore, ethnic variations indicated that Aryan students, particularly in the Brahmin and Chhetri communities has higher prevalence of myopia than other groups. CONCLUSIONS: The higher prevalence of myopia among the undergraduate students in Far West Nepal was seen at the age of 19. This study suggests the critical risk factors associated with myopia, including age, outdoor activities, screen time, parental history, and ethnic variations which need early health initiatives with preventive strategies for the growing incidence of myopia. FAU - Bhatta, Sabitri AU - Bhatta S AD - Geta Hospital, Kailali, Nepal. FAU - Kumar Yadav, Pramod AU - Kumar Yadav P AD - Geta Hospital, Kailali, Nepal. FAU - Awasthi, Suresh AU - Awasthi S AD - Geta Eye Hospital, Kailali, Nepal. FAU - Giri, Krishna AU - Giri K AD - Prithivi Narayan campus, Tribhuvan University, Kaski, Nepal. LA - eng PT - Journal Article DEP - 20260126 PL - Nepal TA - J Nepal Health Res Counc JT - Journal of Nepal Health Research Council JID - 101292936 SB - IM MH - Humans MH - *Myopia/epidemiology/ethnology MH - Nepal/epidemiology MH - Risk Factors MH - Cross-Sectional Studies MH - Young Adult MH - Prevalence MH - Female MH - Adolescent MH - Male MH - Adult MH - *Students/statistics & numerical data MH - Universities OTO - NOTNLM OT - Myopia: near work; outdoor activity; undergraduate students and ethnicity. EDAT- 2026/03/19 07:11 MHDA- 2026/03/19 07:12 CRDT- 2026/03/19 01:23 PHST- 2025/07/13 00:00 [received] PHST- 2026/01/25 00:00 [accepted] PHST- 2026/03/19 07:12 [medline] PHST- 2026/03/19 07:11 [pubmed] PHST- 2026/03/19 01:23 [entrez] AID - 10.33314/jnhrc.v23i03.4653 [doi] PST - epublish SO - J Nepal Health Res Counc. 2026 Jan 26;23(3):457-466. doi: 10.33314/jnhrc.v23i03.4653. PMID- 41851868 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Mar 19 TI - DAGIS Salo cohort profile: a longitudinal and cross-sectional study to identify environmental and individual factors linked to health behaviours, recovery from stress, weight and learning outcomes among Finnish schoolchildren. LID - 10.1186/s12889-026-27007-x [doi] LID - 1384 AB - BACKGROUND: The global prevalence of childhood obesity has increased significantly, with World Health Organisation emphasising the importance of early childhood for promoting healthy growth and development. In Finland, 29% of boys and 18% of girls aged 2-16 years are living with overweight or obesity. The DAGIS Intervention in 2017-2018 in Southwest Finland aimed to promote healthy energy-balance related behaviours (EBRBs) and self-regulation skills in early childhood education and family settings, hypothesising that improvements would reduce overweight prevalence, increase well-being, and enhance learning outcomes in pre-adolescence. DAGIS Salo is a follow-up study of the DAGIS Intervention, with parallel recruitment of a new cross-sectional sample. This paper describes the DAGIS Salo cohort profile, covering study design, recruitment, measurements, data processing and participant characteristics. METHODS: The DAGIS Salo study (2023-2024) consisted of a larger cross-sectional sample and, within it, a six-year follow-up sample from the DAGIS Intervention. All primary schoolchildren in grades 3-6 in Salo municipality in Southwest Finland and their caregivers were invited to participate, regardless of participation in the DAGIS Intervention. Schoolchildren provided information on movement behaviours (accelerometry), screen use, food consumption, psychosocial well-being, and recovery from stress (heart rate variability). Trained data collectors measured schoolchildren's anthropometrics and administered learning tests. Caregivers provided information on physical and social home environment and child temperament. School and food service personnel provided information on the school environment. RESULTS: The DAGIS Salo cohort consists of 540 schoolchildren (27% of eligible participants), including the DAGIS Intervention follow-up sample of 207 schoolchildren (31% of participants from the DAGIS Intervention). The average age of schoolchildren in the cohort was 11 (+/- 1.15) years and 54% of participants were girls. CONCLUSION: The DAGIS Salo study utilised a longitudinal and cross-sectional design, objective measures and validated instruments, and multiple perspectives to examine physical and social environments that influence schoolchildren's health and behaviour. Study findings can advance equity in schoolchildren's health, well-being and learning by identifying modifiable factors within early childhood education, home and school environments, to better support EBRBs, well-being and learning of those who need it most. TRIAL REGISTRATION: ISRCTN57165350 (8 January 2015). FAU - Kailaheimo-Bjorkqvist, Josefine AU - Kailaheimo-Bjorkqvist J AUID- ORCID: 0000-0002-5992-1758 AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. AD - Institute of Applied Health Sciences, University of Aberdeen, Foresterhill, Aberdeen, AB25 2ZD, UK. FAU - Vepsalainen, Henna AU - Vepsalainen H AD - Department of Food and Nutrition, University of Helsinki, P.O. Box 66, Helsinki, 00014, Finland. FAU - Kesalainen, Jonna AU - Kesalainen J AD - School of Applied Educational Science and Teacher Education, University of Eastern Finland, P.O. Box 111, Joensuu, 80101, Finland. FAU - Lehto, Reetta AU - Lehto R AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. AD - Department of Food and Nutrition, University of Helsinki, P.O. Box 66, Helsinki, 00014, Finland. FAU - Launistola, Henna AU - Launistola H AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. FAU - Rahkola, Jenna AU - Rahkola J AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. FAU - Kinnunen, Satu AU - Kinnunen S AD - Department of Food and Nutrition, University of Helsinki, P.O. Box 66, Helsinki, 00014, Finland. FAU - Tilli, Emmi AU - Tilli E AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. AD - Department of Food and Nutrition, University of Helsinki, P.O. Box 66, Helsinki, 00014, Finland. FAU - Wackstrom, Nanna AU - Wackstrom N AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. AD - Faculty of Medicine, University of Helsinki, PO BOX 63, Helsinki, 00014, Finland. FAU - Serasinghe, Nithya AU - Serasinghe N AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. AD - Department of Food and Nutrition, University of Helsinki, P.O. Box 66, Helsinki, 00014, Finland. FAU - Muhumed, Idil AU - Muhumed I AD - Department of Food and Nutrition, University of Helsinki, P.O. Box 66, Helsinki, 00014, Finland. FAU - Klingstedt, Ossian AU - Klingstedt O AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. AD - Faculty of Arts, Psychology and Theology, Akademi University, Tehtaankatu 2, Turku, 20500, Finland. FAU - Roos, Eva AU - Roos E AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. AD - Department of Public Health, University of Helsinki, PO BOX 20, Helsinki, 00014, Finland. AD - Department of Food Studies, Nutrition and Dietetics, Uppsala University, PO Box 560, Uppsala, 751 22, Sweden. FAU - Sajaniemi, Nina AU - Sajaniemi N AD - School of Applied Educational Science and Teacher Education, University of Eastern Finland, P.O. Box 111, Joensuu, 80101, Finland. FAU - Erkkola, Maijaliisa AU - Erkkola M AD - Department of Food and Nutrition, University of Helsinki, P.O. Box 66, Helsinki, 00014, Finland. FAU - Ray, Carola AU - Ray C AD - Folkhalsan Research Center, Topeliuksenkatu 20, Helsinki, 00250, Finland. Carola.Ray@helsinki.fi. AD - Department of Food and Nutrition, University of Helsinki, P.O. Box 66, Helsinki, 00014, Finland. Carola.Ray@helsinki.fi. LA - eng PT - Journal Article DEP - 20260319 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Finland/epidemiology MH - Cross-Sectional Studies MH - Female MH - Child MH - Male MH - *Health Behavior MH - Longitudinal Studies MH - *Learning MH - *Stress, Psychological/epidemiology MH - *Pediatric Obesity/prevention & control/epidemiology MH - *Body Weight MH - Follow-Up Studies MH - Adolescent MH - *Health Promotion PMC - PMC13123094 OTO - NOTNLM OT - Adolescent OT - Children OT - Food intake OT - Intervention follow-up OT - Mental health OT - Physical activity OT - Preschool OT - Screen time OT - Sleep OT - Socioeconomic status COIS- Declarations. Ethics approval and consent to participate: Ethical approval was granted from the University of Helsinki Ethical Review Board in the Humanities and Social and Behavioural Sciences for both the DAGIS Intervention in 2017-2018 (statement 22/2017) and the DAGIS Salo study in 2023-2024 (statement 46/2023). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/19 07:10 MHDA- 2026/06/27 12:37 PMCR- 2026/03/19 CRDT- 2026/03/19 00:57 PHST- 2025/04/17 00:00 [received] PHST- 2026/03/10 00:00 [accepted] PHST- 2026/06/27 12:37 [medline] PHST- 2026/03/19 07:10 [pubmed] PHST- 2026/03/19 00:57 [entrez] PHST- 2026/03/19 00:00 [pmc-release] AID - 10.1186/s12889-026-27007-x [pii] AID - 27007 [pii] AID - 10.1186/s12889-026-27007-x [doi] PST - epublish SO - BMC Public Health. 2026 Mar 19;26(1):1384. doi: 10.1186/s12889-026-27007-x. PMID- 41851782 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260926 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 25 IP - 1 DP - 2026 Mar 18 TI - Cow's milk compared to oat drink and its implications for lipid profile- a pilot randomized controlled trial. LID - 10.1186/s12937-026-01314-w [doi] LID - 54 AB - A recent dietary trend involves replacing cow's milk with plant-based drink alternatives. This shift is motivated by the perception that plant-based options are healthier and more environmentally sustainable. One of the most popular options is oat drink; however, the health effects of consuming oat drink as a replacement for cow' s milk are not well studied. The EFSA health claims state that beta-glucans in oat drink have beneficial effects on cholesterol; however, consumption of oat drink at doses aligned with food-based guidelines for milk and dairy products has not been examined in real-world scenarios.Thus, the primary goal of this pilot randomized controlled trial was to assess the effectiveness of consuming 600 mL of oat drink daily versus 600 mL of cow's milk daily over four weeks on blood lipids (total cholesterol, LDL-cholesterol, HDL-cholesterol, and triglycerides) in healthy young women in a real-world setting. A four-week, open-label, parallel-arm randomized controlled trial was conducted on women aged 18-40 years who habitually drink cow's milk. Participants were randomized 1:1 to consume either 600 mL/day of oat drink or 600 mL/day of semi-skimmed cow's milk. Two baseline visits were conducted before the intervention, during which informed consent, anthropometric measurements, 24-hour recalls, and blood samples were collected. During the intervention, participants recorded their milk intake in compliance diaries. Two final visits were held at the end of the study, where dietary recalls, anthropometry, and blood samples were repeated.Of the 33 women enrolled, 32 completed the trial. Baseline characteristics were similar across groups, including age (median 23 years), BMI (median 22. 9 kg/m (2)), and dietary intake. Over the four weeks, the oat drink group experienced a significant reduction in mean total cholesterol (-0.3 mmol/L (95% CI 0.6 to 0.0; p = 0.026) and LDL-cholesterol (-0.4 mmol/L (95% CI - 0.6 to - 0. 2; p = 0.002), compared to the cow' s milk control group. No differences were observed between the groups in HDL- cholesterol, or triglycerides.In conclusion, these results indicate that replacing cow's milk with oat drink may lead to modest reductions in total and LDL‑cholesterol over four weeks in healthy young women under real-world conditions. The compliance and feasibility of this effectiveness study were good, with high compliance rates. ClinicalTrials.gov NCT06764173. FAU - Rosendahl-Riise, Hanne AU - Rosendahl-Riise H AD - Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Jonas Lies vei 91, Bergen, N-5020, Norway. hanne.rosendahl-riise@uib.no. FAU - Gravrok, Eline Olsen AU - Gravrok EO AD - Department of Clinical Medicine, University of Bergen, Bergen, Norway. FAU - Rung, Sarah Louise AU - Rung SL AD - Department of Clinical Medicine, University of Bergen, Bergen, Norway. FAU - Dierkes, Jutta AU - Dierkes J AD - Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Jonas Lies vei 91, Bergen, N-5020, Norway. FAU - Aakre, Inger AU - Aakre I AD - Institute of Marine Research, Bergen, Norway. LA - eng SI - ClinicalTrials.gov/NCT06764173 PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20260318 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 RN - 0 (Triglycerides) RN - 0 (Cholesterol, LDL) RN - 0 (Cholesterol, HDL) RN - 97C5T2UQ7J (Cholesterol) RN - 0 (Lipids) SB - IM MH - Humans MH - Female MH - *Milk MH - Pilot Projects MH - *Avena MH - Animals MH - Adult MH - Young Adult MH - Adolescent MH - Triglycerides/blood MH - Cholesterol, LDL/blood MH - Cholesterol, HDL/blood MH - Cattle MH - Cholesterol/blood MH - *Lipids/blood MH - *Beverages MH - Body Mass Index PMC - PMC13112611 OTO - NOTNLM OT - Cow's milk OT - LDL-cholesterol OT - Oat drink OT - Pilot randomized controlled trial COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/03/19 07:11 MHDA- 2026/06/27 12:36 PMCR- 2026/03/18 CRDT- 2026/03/19 00:52 PHST- 2025/12/19 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/06/27 12:36 [medline] PHST- 2026/03/19 07:11 [pubmed] PHST- 2026/03/19 00:52 [entrez] PHST- 2026/03/18 00:00 [pmc-release] AID - 10.1186/s12937-026-01314-w [pii] AID - 1314 [pii] AID - 10.1186/s12937-026-01314-w [doi] PST - epublish SO - Nutr J. 2026 Mar 18;25(1):54. doi: 10.1186/s12937-026-01314-w. PMID- 41851699 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Mar 19 TI - Effectiveness of an intervention package on the continuum of care among mothers and their knowledge of non-communicable diseases: a cluster randomised controlled trial in Myanmar. LID - 10.1186/s12889-026-27026-8 [doi] LID - 1383 AB - BACKGROUND: Strategies for the continuum of care (CoC) for mothers and newborns have yet to be adequately evaluated in Myanmar. Similarly, the feasibility of integrating non-communicable diseases (NCDs) education into routine maternal, newborn and child health (MNCH) services remains unexamined. This study assessed the effect of an intervention package on achieving the CoC for mothers and their knowledge of NCDs in Myanmar. METHODS: In three townships (Pantanaw, Wakema and Ingapu) of Myanmar, we randomly allocated clusters (primary health centres) to the intervention group (n=16) and the control group (n=16). The intervention group received a package, including a one-page CoC card and four health education sessions on NCDs from pregnancy to postpartum. The control group received routine services. We enrolled pregnant women who received their first ANC visit between 12 and 20 weeks of gestation during the trial enrolment period. The outcomes were (1) the CoC completion among women with babies born alive (measured by the proportion of mothers who received ANC at least four times, delivered with a skilled birth attendant, and received postnatal care four times) and (2) their NCD knowledge (measured by a test on NCDs in general, hypertension, diabetes, anaemia and nutrition). The analysis was conducted following the intention-to-treat (ITT) and per-protocol (PP) principles. A mixed-effect logistic regression was used to assess the effect of the CoC card, and a generalised estimation equation was used to assess the effect of health education. RESULTS: A total of 630 pregnant women participated at the baseline. The intervention group was more likely to complete CoC, with adjusted odds ratios (AOR) 6.8 (95% confidence interval (CI) 2.3-20.4) in the ITT analysis and AOR 7.0 (95% CI 2.3-21.6) in the PP analysis (both p = 0.001). NCD knowledge scores also improved in the intervention group by 2.2 points in the ITT and 3.5 points in the PP analyses (p = 0.010 and p < 0.001, respectively). CONCLUSIONS: The intervention package enhanced the CoC completion of mothers and their NCD knowledge. Given the success of this intervention, future efforts that prioritise integrating health education for NCDs into routine MCH services are warranted into routine MCH services at the primary healthcare level in Myanmar and similar LMIC settings. CLINICAL TRIAL NUMBER: NCT03145155. Registered on April 20, 2017 FAU - Thandar, Moe Moe AU - Thandar MM AD - Bureau of Global Health Cooperation, Japan Institute for Health Security, Tokyo, Japan. moe2thandar@gmail.com. AD - Department of Community and Global Health, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan. moe2thandar@gmail.com. FAU - Kiriya, Junko AU - Kiriya J AD - Department of Community and Global Health, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan. FAU - Shibanuma, Akira AU - Shibanuma A AD - Department of Community and Global Health, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan. FAU - Tin, Khaing Nwe AU - Tin KN AD - Maternal and Reproductive Health Division, Department of Public Health, Ministry of Health and Sports, Nay Pyi Taw, Republic of the Union of Myanmar. FAU - Win, Hla Hla AU - Win HH AD - University of Public Health, Yangon, Republic of the Union of Myanmar. FAU - Saw, Yu Mon AU - Saw YM AD - Department of Community and Global Health, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan. FAU - Iwamoto, Azusa AU - Iwamoto A AD - Bureau of Global Health Cooperation, Japan Institute for Health Security, Tokyo, Japan. FAU - Jimba, Masamine AU - Jimba M AD - Department of Community and Global Health, Graduate School of Medicine, the University of Tokyo, Tokyo, Japan. AD - Department of Environmental and Sustainable Engineering, Chulalongkorn University, Bangkok, Thailand. LA - eng SI - ClinicalTrials.gov/NCT03145155 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260319 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Myanmar MH - *Noncommunicable Diseases/therapy MH - Adult MH - Pregnancy MH - *Health Knowledge, Attitudes, Practice MH - *Continuity of Patient Care/organization & administration MH - *Mothers/psychology MH - Cluster Analysis MH - Infant, Newborn MH - Prenatal Care MH - Young Adult MH - *Health Education PMC - PMC13123193 OTO - NOTNLM OT - Myanmar OT - antenatal OT - continuum of care OT - intervention OT - non-communicable diseases OT - postnatal OT - skilled birth attendant COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the principles outlined in the Declaration of Helsinki. We obtained ethics approval from the Research Ethics Committee of the Graduate School of Medicine, University of Tokyo, Japan (Serial number 11498), and the Department of Medical Research (ERC number 001117), Myanmar. We explained to pregnant women the purpose of the study and the confidentiality of the data. We obtained written informed consent from pregnant women in both intervention and control groups during recruitment and baseline data collection. The control group participants had no access to the intervention after the trial period because the purpose of the trial was to determine whether the intervention worked. Moreover, standard care or usual practice in the control group was considered ethically acceptable. The dataset was accessed only by authorised persons and handled according to ethical guidelines. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/19 07:10 MHDA- 2026/06/27 12:38 PMCR- 2026/03/19 CRDT- 2026/03/19 00:48 PHST- 2025/09/29 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/06/27 12:38 [medline] PHST- 2026/03/19 07:10 [pubmed] PHST- 2026/03/19 00:48 [entrez] PHST- 2026/03/19 00:00 [pmc-release] AID - 10.1186/s12889-026-27026-8 [pii] AID - 27026 [pii] AID - 10.1186/s12889-026-27026-8 [doi] PST - epublish SO - BMC Public Health. 2026 Mar 19;26(1):1383. doi: 10.1186/s12889-026-27026-8. PMID- 41851653 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Mar 18 TI - Accuracy of Mansoura Early Feeding Skills Assessment score (MEFSA) in identification of oral feeding readiness in preterm infants. LID - 10.1186/s12887-026-06586-z [doi] LID - 281 AB - BACKGROUND: Oral feeding readiness is a complex concept. More evidence is needed to approach the initiation of oral feedings in preterm infants. Recognition and support of oral feeding readiness may decrease hospital stays and reduce healthcare costs. PURPOSE: To assess the accuracy of the pre-feeding section of the Mansoura Early Feeding Skills Assessment (MEFSA) score on the initiation of oral feeding in preterm infants and identify a cutoff point for oral feeding readiness concerning the oral feeding skill (OFS) level. Furthermore, to confirm the concordance between the MEFSA and the OFS level. METHODS: Transversal and analytical study of 41 preterm infants. Infants were assessed before the first oral feeding by the pre-feeding section. Furthermore, the first oral feeding act is evaluated by the during-feeding section of MEFSA and OFS level. The cutoff point was estimated based on the OFS level and success using a receiver operating characteristic (ROC) curve. Pearson correlations were obtained between the pre-feeding and during-feeding sections, as well as the association between the during-feeding section and OFS score. RESULTS: MEFSA's overall diagnostic accuracy was 82.5%. Cutoff points for oral feeding readiness were determined to be greater than 77 and greater than 77.5, concerning OFS level and oral feeding success, respectively. A moderate positive correlation coefficient existed between the pre-feeding and during-feeding sections of MEFSA. CONCLUSION: The pre-feeding section of MEFSA is a straightforward, quick instrument that can be used in clinical practice. It has a moderate to high accuracy in pinpointing the ideal time for readiness for oral feeding. However, more research is needed. We suggest combining the pre-feeding and during-feeding sections in clinical practice. FAU - El-Kassas, Omnia AU - El-Kassas O AD - Phoniatrics Unit, ORL Department, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt. FAU - Saad, Maii AU - Saad M AD - Phoniatrics Unit, ORL Department, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt. FAU - Amer, Ayman AU - Amer A AD - Phoniatrics Unit, ORL Department, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt. FAU - Abdel-Hady, Hesham AU - Abdel-Hady H AD - Neonatology Unit, Pediatric Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt. FAU - Abou-Elsaad, Tamer AU - Abou-Elsaad T AUID- ORCID: 0000-0002-8591-966X AD - Phoniatrics Unit, ORL Department, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt. taboelsaad@hotmail.com. AD - Nile Valley University, Fayoum, Egypt. taboelsaad@hotmail.com. LA - eng PT - Journal Article DEP - 20260318 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Infant, Newborn MH - *Infant, Premature MH - Female MH - Male MH - Cross-Sectional Studies MH - *Sucking Behavior MH - ROC Curve MH - *Feeding Behavior MH - *Bottle Feeding PMC - PMC13063901 OTO - NOTNLM OT - Full oral feeding OT - Oral feeding skills OT - Prematurity OT - Readiness OT - Scale COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the principles of the Declaration of Helsinki. Approval was granted by the Institutional Review Board (IRB) of Mansoura Faculty of Medicine - Mansoura University (MS.19.04.572). Informed consent was obtained from the legal guardians of all enrolled participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/19 07:11 MHDA- 2026/06/27 12:36 PMCR- 2026/03/18 CRDT- 2026/03/19 00:45 PHST- 2024/11/01 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/06/27 12:36 [medline] PHST- 2026/03/19 07:11 [pubmed] PHST- 2026/03/19 00:45 [entrez] PHST- 2026/03/18 00:00 [pmc-release] AID - 10.1186/s12887-026-06586-z [pii] AID - 6586 [pii] AID - 10.1186/s12887-026-06586-z [doi] PST - epublish SO - BMC Pediatr. 2026 Mar 18;26(1):281. doi: 10.1186/s12887-026-06586-z. PMID- 41850781 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 2047-6310 (Electronic) IS - 2047-6302 (Linking) VI - 21 IP - 3 DP - 2026 Mar TI - Machine Learning Prediction of Obesity Development in Children With Overweight Using Longitudinal Body Composition Data. PG - e70105 LID - 10.1111/ijpo.70105 [doi] AB - BACKGROUND: Children with overweight (body mass index [BMI] between the 85th and 95th percentiles) represent a critical target for obesity prevention, with obesity progression rates 10- to 20-fold higher than normal-weight peers. OBJECTIVES: This study developed machine learning models to predict obesity in this high-risk group using anthropometric and bioelectrical impedance analysis parameters. METHODS: We analysed longitudinal data from 2801 overweight Korean children aged 7-9 years. XGBoost models integrated anthropometric measurements, bioelectrical impedance-derived body composition, standardised deviation scores and growth velocity parameters to predict obesity (BMI >/= 95th percentile). Sex-stratified models were evaluated using area under the receiver operating characteristic curve (AUROC) with bootstrap validation. Shapley Additive exPlanations (SHAP) identified key predictive features. RESULTS: Obesity developed in 32.3% of males and 25.4% of females during follow-up. Models achieved AUROC scores of 0.671 (95% CI: 0.619-0.721) for males and 0.652 (95% CI: 0.589-0.700) for females. Key predictors included standardised weight and adiposity measures, height-adjusted skeletal muscle mass and growth velocity parameters. CONCLUSIONS: Machine learning models demonstrated effective predictive performance for obesity in children with overweight. Incorporating standardised adiposity measures and growth velocity beyond static anthropometric data provides a robust framework for risk stratification in this high-risk population. CI - (c) 2026 World Obesity Federation. FAU - Chun, Dohyun AU - Chun D AUID- ORCID: 0000-0003-3031-4011 AD - College of Business Administration, Kangwon National University, Chuncheon, Gangwon-do, Korea. AD - Research Team, GP Co. Ltd., Gwangmyeong-si, Gyeonggi-do, Korea. FAU - Rhie, Young-Jun AU - Rhie YJ AD - Department of Pediatrics, Korea University College of Medicine, Seoul, Korea. FAU - Sawyer, Jason AU - Sawyer J AD - Department of Biological and Biomedical Sciences, Bryant University, Smithfield, Rhode Island, USA. FAU - Kang, Jongho AU - Kang J AD - Research Team, GP Co. Ltd., Gwangmyeong-si, Gyeonggi-do, Korea. AD - College of Business Administration, Chonnam National University, Gwangju, Korea. FAU - Yoon, Nathan AU - Yoon N AD - Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, California, USA. FAU - Kim, Jihun AU - Kim J AUID- ORCID: 0000-0002-2957-8776 AD - Research Team, GP Co. Ltd., Gwangmyeong-si, Gyeonggi-do, Korea. AD - College of Humanities & Social Sciences Convergence, Yonsei University, Wonju, Gangwon-do, Korea. AD - Yonsei Institute of AI Data Convergence Science, Yonsei University, Wonju, Gangwon-do, Korea. LA - eng GR - 2025-RISE-10-006/the Ministry of Education (MOE) and the Gangwon State (G.S.), Republic of Korea/ GR - Regional Innovation System and Education (RISE) program/ PT - Journal Article PL - England TA - Pediatr Obes JT - Pediatric obesity JID - 101572033 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - *Body Composition MH - Longitudinal Studies MH - Body Mass Index MH - *Machine Learning MH - *Pediatric Obesity/epidemiology/diagnosis MH - Predictive Learning Models MH - Republic of Korea/epidemiology MH - Electric Impedance MH - Boosting Machine Learning Algorithms MH - *Overweight MH - Prediction Algorithms MH - Predictive Value of Tests OTO - NOTNLM OT - body composition OT - children with overweight OT - growth velocity OT - machine learning OT - paediatric obesity prediction EDAT- 2026/03/19 01:32 MHDA- 2026/03/19 01:33 CRDT- 2026/03/18 21:52 PHST- 2026/03/11 00:00 [revised] PHST- 2025/12/10 00:00 [received] PHST- 2026/03/12 00:00 [accepted] PHST- 2026/03/19 01:33 [medline] PHST- 2026/03/19 01:32 [pubmed] PHST- 2026/03/18 21:52 [entrez] AID - 10.1111/ijpo.70105 [doi] PST - ppublish SO - Pediatr Obes. 2026 Mar;21(3):e70105. doi: 10.1111/ijpo.70105. PMID- 41850572 OWN - NLM STAT- Publisher LR - 20260318 IS - 1098-4275 (Electronic) IS - 0031-4005 (Linking) DP - 2026 Mar 19 TI - Growth of Children With Cerebral Palsy and Health Outcomes. LID - e2025072504 [pii] LID - 10.1542/peds.2025-072504 [doi] AB - OBJECTIVE: The California-based cerebral palsy (CP) growth charts, published in Pediatrics in 2011, demonstrated a link between Gross Motor Function Classification System (GMFCS)-stratified weight percentile (GWt%-ile) and mortality, but use has been limited. This secondary analysis from the North American Growth in Cerebral Palsy Project (NAGCPP) aims to evaluate the charts and the link between GWt%-ile and additional health markers. PATIENTS AND METHODS: NAGCPP included weight and triceps skinfold thickness (TSF) in 197 boys and 146 girls, aged 2 to 18 years, GMFCS levels III through V, with CP. Health care utilization and social participation were assessed by questionnaire. GWt%-ile was determined from sex and GMFCS-specific weight charts. Using the 20th GWt%-ile cutoff previously associated with mortality risk over 3 years, we assessed the relationship with health care utilization and social participation with and without TSF and medical comorbidities. RESULTS: NAGCPP weight data fit the CP charts (goodness-of-fit P = .14 for boys; P > .25 for girls). Adjusting for sex and GMFCS, children below the 20th GWt%-ile reported 5.7 times (95% CI, 2.2-14.8) more hospital stays (P < .001), 3.1 times (95% CI, 1.3-7.4) more missed regular programs (P < .001), and 2.8 times (95% CI, 1.2-6.5) more total days (P = .02) the family or child missed regular activities. TSF (fat stores) and severe feeding problems were associated independently with health and participation. CONCLUSION: This study validates the CP growth charts and documents an association between GWt%-ile and markers of health and participation other than mortality. CP growth charts warrant consideration for clinical decision-making and research. CI - Copyright (c) 2026 by the American Academy of Pediatrics. FAU - Stevenson, Richard D AU - Stevenson RD AD - University of Virginia, Charlottesville, Virginia. FAU - Conaway, Mark R AU - Conaway MR AD - University of Virginia, Charlottesville, Virginia. FAU - Worley, Gordon AU - Worley G AD - Duke University, Durham, North Carolina. FAU - Stallings, Virginia A AU - Stallings VA AD - University of Pennsylvania and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. LA - eng PT - Journal Article DEP - 20260319 PL - United States TA - Pediatrics JT - Pediatrics JID - 0376422 SB - IM EDAT- 2026/03/19 01:32 MHDA- 2026/03/19 01:32 CRDT- 2026/03/18 20:16 PHST- 2025/05/18 00:00 [received] PHST- 2025/11/03 00:00 [accepted] PHST- 2026/03/19 01:32 [medline] PHST- 2026/03/19 01:32 [pubmed] PHST- 2026/03/18 20:16 [entrez] AID - 206907 [pii] AID - 10.1542/peds.2025-072504 [doi] PST - aheadofprint SO - Pediatrics. 2026 Mar 19:e2025072504. doi: 10.1542/peds.2025-072504. PMID- 41850540 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260828 IS - 1528-0012 (Electronic) IS - 0016-5085 (Linking) VI - 171 IP - 2 DP - 2026 Aug TI - Intestinal Ultrasound Scan in Acute Severe Ulcerative Colitis in Children: A Multicenter Prospective Study on Behalf of the Porto Inflammatory Bowel Disease Working Group of European Society for Paediatric Gastroenterology Hepatology and Nutrition. PG - 314-324 LID - S0016-5085(26)00232-5 [pii] LID - 10.1053/j.gastro.2026.02.034 [doi] AB - BACKGROUND & AIMS: The aim of this study was to evaluate the potential role of intestinal ultrasound scan (IUS) in predicting short-term treatment outcomes in pediatric acute severe ulcerative colitis (ASUC). METHODS: This prospective longitudinal study was conducted across 10 European centers. Biologic-naive children with ASUC were included. Each patient underwent 2 IUS, the first within 48 hours of initiating intravenous corticosteroids, and the second between day 5 and 7 of treatment. Key metrics assessed included colonic wall thickness (CWT), colonic wall stratification (CWS), and colonic wall blood flow via power Doppler. The Milan ultrasound score was also calculated for each colonic quadrant. RESULTS: The study prospectively enrolled 60 patients (61.7% girls; median age at enrollment, 13.5 years). Escalation to infliximab was required in 39 patients (65%) who were corticosteroid nonresponders. Nonresponders had significantly higher CWT assessed in the left-lower quadrant (LLQ) (6 vs 4.2 mm, P < .001) and left upper quadrant (5 vs 4 mm, P = .003) and had more frequent hypervascularity (Limberg's score >/=3) assessed in the same sections. Receiver operator characteristic curve analysis identified LLQ CWT >5 mm (area under the curve [AUC] = 0.819) and Milan Ultrasound Criteria >7.8 (AUC = 0.834) as optimal cutoffs for predicting steroid resistance. Ten patients (16.7%) who did not respond to medical therapy underwent colectomy within the 8-week period of the study. At the second IUS, CWT >4.8 mm and Milan Ultrasound Criteria >8.7 in LLQ were associated with medical therapy failure (AUC = 0.844 and 0.878, respectively). Patients in steroid-free clinical remission at week 8 had lower CWT (3.5 vs 5 mm, P = .037) and Milan Ultrasound Criteria (5.3 vs 8.7, P < .001) at the second IUS. CONCLUSIONS: IUS is an effective noninvasive tool to predict first-line therapy failure and the need for colectomy in patients with ASUC. CI - Copyright (c) 2026 American Gastroenterological Association Institute. Published by Elsevier Inc. All rights reserved. FAU - Scarallo, Luca AU - Scarallo L AD - Gastroenterology and Nutrition Unit, Meyer Children's Hospital IRCCS, Florence, Italy; Department of NEUROFARBA, University of Florence, Florence, Italy. FAU - Alvisi, Patrizia AU - Alvisi P AD - Pediatric Gastroenterology Unit, Maggiore Hospital, Bologna, Italy. FAU - Bramuzzo, Matteo AU - Bramuzzo M AD - Institute for Maternal and Child Health IRCCS "Burlo Garofolo,", Trieste, Italy. FAU - Domanico, Andrea AU - Domanico A AD - Department of Internal Medicine, Centre of Research and Learning in Ultrasound, Maggiore Hospital, Bologna, Italy. FAU - Kierkus, Jaroslaw AU - Kierkus J AD - The Children Memorial Health Institute, Warsaw, Poland. FAU - Matar, Manar AU - Matar M AD - Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petah Tikva, Israel; Gray Faculty of Medical and Health Sciences, Tel-Aviv University, Tel Aviv, Israel. FAU - Strisciuglio, Caterina AU - Strisciuglio C AD - Department of Woman, Child, General and Specialistic Surgery, University of Campania Luigi Vanvitelli School of Medicine and Surgery, Naples, Italy. FAU - De Laffolie, Jan AU - De Laffolie J AD - General Paediatrics and Neonatology, University Childrens Hospital Giessen, Giessen, Germany. FAU - Broekaert, Ilse AU - Broekaert I AD - Department of Pediatrics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany. FAU - Aloi, Marina AU - Aloi M AD - Pediatric Gastroenterology and Cystic Fibrosis Unit, Department of Pathophysiology and Transplantation, Universita degli Studi di Milano, Fondazione IRCCS Ca Granda, Ospedale Maggiore Policlinico di Milano, Milan, Italy. FAU - Velasco Rodriguez-Belvis, Marta AU - Velasco Rodriguez-Belvis M AD - Gastroenterology and Nutrition Unit, Hospital Infantil Universitario Nino Jesus, Madrid, Spain. FAU - Renzo, Sara AU - Renzo S AD - Gastroenterology and Nutrition Unit, Meyer Children's Hospital IRCCS, Florence, Italy. FAU - Labriola, Flavio AU - Labriola F AD - Pediatric Gastroenterology Unit, Maggiore Hospital, Bologna, Italy. FAU - Tasciotti, Laura AU - Tasciotti L AD - Radiology Unit, Meyer Children's Hospital IRCCS, Florence, Italy. FAU - Dragoni, Gabriele AU - Dragoni G AD - IBD Referral Centre, Clinical Gastroenterology Unit, Careggi University Hospital, Florence, Italy; Department of Experimental and Clinical Biomedical Sciences, University of Florence, Florence, Italy. FAU - Lionetti, Paolo AU - Lionetti P AD - Gastroenterology and Nutrition Unit, Meyer Children's Hospital IRCCS, Florence, Italy; Department of NEUROFARBA, University of Florence, Florence, Italy. Electronic address: paolo.lionetti@unifi.it. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260316 PL - United States TA - Gastroenterology JT - Gastroenterology JID - 0374630 RN - B72HH48FLU (Infliximab) RN - 0 (Gastrointestinal Agents) RN - 0 (Adrenal Cortex Hormones) RN - Pediatric ulcerative colitis SB - IM MH - Humans MH - Female MH - Prospective Studies MH - *Colitis, Ulcerative/diagnostic imaging/drug therapy MH - Adolescent MH - Child MH - Male MH - Infliximab/therapeutic use/administration & dosage MH - Severity of Illness Index MH - Treatment Outcome MH - Longitudinal Studies MH - Predictive Value of Tests MH - Gastrointestinal Agents/therapeutic use MH - *Colon/diagnostic imaging/blood supply/drug effects MH - Adrenal Cortex Hormones/administration & dosage/therapeutic use MH - Europe MH - Acute Disease MH - *Ultrasonography, Doppler MH - Ultrasonography MH - ROC Curve MH - Drug Resistance OTO - NOTNLM OT - Bowel Ultrasound OT - Colectomy OT - Inflammatory Bowel Diseases OT - Infliximab EDAT- 2026/03/19 01:32 MHDA- 2026/07/23 05:36 CRDT- 2026/03/18 20:13 PHST- 2025/08/13 00:00 [received] PHST- 2026/02/03 00:00 [revised] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/07/23 05:36 [medline] PHST- 2026/03/19 01:32 [pubmed] PHST- 2026/03/18 20:13 [entrez] AID - S0016-5085(26)00232-5 [pii] AID - 10.1053/j.gastro.2026.02.034 [doi] PST - ppublish SO - Gastroenterology. 2026 Aug;171(2):314-324. doi: 10.1053/j.gastro.2026.02.034. Epub 2026 Mar 16. PMID- 41850191 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260724 IS - 1879-2219 (Electronic) IS - 0966-6362 (Linking) VI - 127 DP - 2026 Jun TI - Relationship between functional lower limb capacity and falls in ambulant children with cerebral palsy. PG - 110147 LID - S0966-6362(26)00055-X [pii] LID - 10.1016/j.gaitpost.2026.110147 [doi] AB - AIM: Ambulant children with cerebral palsy (CP) are at a high risk of falls. It is important to identify characteristics associated with increased falls and understand which clinical measures are associated with falls in this population. METHOD: This study explored parent-reported falls of 66 children with CP (Gross Motor Function Classification System [GMFCS] I - III) and the associations between lower limb functional measures (6-Minute Walk Test, Muscle Power Sprint Test, 10 Metre Walk Test, Sit-to-Stand, Lateral Step-up, Kneel-to-Stand) and the number of falls. Receiver operating characteristic (ROC) curve analysis identified score thresholds for the likelihood of falling more than average. RESULTS: 81% of children fell at least once in the previous month, with an average of 11 falls and 44% children who fell were injured. Children in GMFCS level II had the greatest number of falls. Poorer performance on Sit-to-Stand, Lateral-Step-Up and Kneel-To-Stand were associated with fall frequency. ROC thresholds for likelihood of above average fall frequency were identified for lateral step-up best side (score 90% of its concentration for all systems investigated for two hours. No additional physical incompatibility occurred., but amoxicillin incompatibility was confirmed. Lipid emulsion stability was maintained, with no system exceeding particle size limits. CONCLUSIONS: Ketamine is safe to co-administer with AmBisome(R), cyclizine, hydromorphone, Intralipid(R), magnesium sulfate, metoclopramide, micafungin, potassium dihydrogen phosphate, sodium dihydrogen phosphate and vancomycin. Our findings are significant for improving pain management in vulnerable patients simultaneously administered the tested drugs with ketamine. CI - (c) 2026 Published by Elsevier Inc. FAU - Varonen, Katriina AU - Varonen K AD - Curtin Medical School, Faculty of Health Sciences, Curtin University, 6102 Bentley, Western Australia, Australia. FAU - Soggee, Johnathan AU - Soggee J AD - Pharmacy Department, Perth Children's Hospital, 6009 Nedlands, Western Australia, Australia. FAU - Isaac, Emily AU - Isaac E AD - Pharmacy Department, Perth Children's Hospital, 6009 Nedlands, Western Australia, Australia. FAU - Luna, Giuseppe AU - Luna G AD - Curtin Medical School, Faculty of Health Sciences, Curtin University, 6102 Bentley, Western Australia, Australia. FAU - Martinez, Jorge AU - Martinez J AD - Curtin Medical School, Faculty of Health Sciences, Curtin University, 6102 Bentley, Western Australia, Australia. FAU - Sunderland, Bruce AU - Sunderland B AD - Curtin Medical School, Faculty of Health Sciences, Curtin University, 6102 Bentley, Western Australia, Australia. FAU - Czarniak, Petra AU - Czarniak P AD - Curtin Medical School, Faculty of Health Sciences, Curtin University, 6102 Bentley, Western Australia, Australia. LA - eng PT - Journal Article DEP - 20260305 PL - United States TA - Explor Res Clin Soc Pharm JT - Exploratory research in clinical and social pharmacy JID - 9918266300706676 PMC - PMC12990329 OTO - NOTNLM OT - Analgesia OT - Children OT - Co-administration OT - Ketamine OT - Oncology OT - cancer COIS- None. EDAT- 2026/03/18 07:25 MHDA- 2026/03/18 07:26 PMCR- 2026/03/05 CRDT- 2026/03/18 04:41 PHST- 2026/01/21 00:00 [received] PHST- 2026/02/28 00:00 [revised] PHST- 2026/03/02 00:00 [accepted] PHST- 2026/03/18 07:26 [medline] PHST- 2026/03/18 07:25 [pubmed] PHST- 2026/03/18 04:41 [entrez] PHST- 2026/03/05 00:00 [pmc-release] AID - S2667-2766(26)00026-0 [pii] AID - 100728 [pii] AID - 10.1016/j.rcsop.2026.100728 [doi] PST - epublish SO - Explor Res Clin Soc Pharm. 2026 Mar 5;22:100728. doi: 10.1016/j.rcsop.2026.100728. eCollection 2026 Jun. PMID- 41846838 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Identification of preschool children's physical fitness phenotypes and their association with multidimensional body shape indicators: a data-driven approach with risk prediction modeling. PG - 1773424 LID - 10.3389/fpubh.2026.1773424 [doi] LID - 1773424 AB - OBJECTIVE: Traditional physical fitness assessments in young children often rely on single indicators, which fail to capture integrated ability patterns. The common use of body mass index (BMI) to link morphology and fitness has limited discriminant validity. This study aimed to identify naturally emerging physical fitness profiles among preschool children in Macao using a data-driven approach and to develop a screening tool based on multi-dimensional body shape indicators-beyond BMI-for identifying children at risk of low physical fitness. METHODS: The sample comprised 3,180 children aged 3-6 years from the Macao China Physical Fitness Surveillance and Physical Activity Survey (2010, 2015, 2020). K-means clustering was performed on six standardized physical fitness test scores to identify intrinsic fitness profiles. One-way ANOVA was used to compare body shape indicators across clusters. Using the low-fitness cluster as the dependent variable, logistic regression identified key morphological predictors, from which a composite discriminant index was constructed. Predictive performance was evaluated using receiver operating characteristic (ROC) curve analysis. RESULTS: Cluster analysis revealed three distinct physical fitness profiles: low, moderate, and high fitness. ANOVA showed significant gradient differences across clusters for all body shape indicators (height, weight, circumferences, etc.). Effect sizes (Cohen's f) ranged from 0.025 to 0.190. Logistic regression identified four core predictors: height, weight, waist circumference, and pelvic width. The composite body shape index demonstrated good discriminative ability for low fitness risk, with an area under the curve (AUC) of 0.779 (95% CI: 0.742-0.800). At the optimal cut-off, sensitivity was 77.7%, and specificity was 66.8%. The index showed consistent performance in sex-stratified analyses (Boys: AUC = 0.87; Girls: AUC = 0.88). CONCLUSION: This study confirms that preschool children's physical fitness develops in distinct, internally coherent profiles, closely associated with body morphology. The composite index based on waist circumference and pelvic width-among other measures-proves more effective than BMI alone in identifying children at risk of low fitness. It offers a practical tool for rapid, early screening during routine health checks and supports targeted physical activity interventions. CI - Copyright (c) 2026 Chen, Zhao, Zhang, Pan, Wang, Chen and Zhang. FAU - Chen, Xiaoxiao AU - Chen X AD - School of Physical Education and Sports Rehabilitation, Jinzhou Medical University, Jinzhou, Liaoning, China. FAU - Zhao, Deqiang AU - Zhao D AD - China Institute of Sport Science, Beijing, China. FAU - Zhang, Aoyu AU - Zhang A AD - School of Medicine, Tianshi College of Tianjin, Tianjin, China. FAU - Pan, Xiang AU - Pan X AD - Graduate School of Health and Sports Science, Juntendo University, Inzai, Japan. FAU - Wang, Chuanmiao AU - Wang C AD - School of Physical Education and Sports Rehabilitation, Jinzhou Medical University, Jinzhou, Liaoning, China. FAU - Chen, Jiaxin AU - Chen J AD - School of Physical Education and Sports Rehabilitation, Jinzhou Medical University, Jinzhou, Liaoning, China. FAU - Zhang, Yanfeng AU - Zhang Y AD - China Institute of Sport Science, Beijing, China. LA - eng PT - Journal Article DEP - 20260302 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Physical Fitness/physiology MH - Phenotype MH - Child, Preschool MH - Female MH - China MH - Male MH - Child MH - Body Mass Index MH - Cluster Analysis MH - Clustering Algorithms MH - Risk Assessment PMC - PMC12989526 OTO - NOTNLM OT - body shape indicators OT - cluster analysis OT - physical fitness phenotypes OT - preschool children OT - risk prediction COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/18 07:25 MHDA- 2026/03/18 07:26 PMCR- 2026/03/02 CRDT- 2026/03/18 04:34 PHST- 2025/12/22 00:00 [received] PHST- 2026/02/07 00:00 [revised] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/03/18 07:26 [medline] PHST- 2026/03/18 07:25 [pubmed] PHST- 2026/03/18 04:34 [entrez] PHST- 2026/03/02 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1773424 [doi] PST - epublish SO - Front Public Health. 2026 Mar 2;14:1773424. doi: 10.3389/fpubh.2026.1773424. eCollection 2026. PMID- 41846650 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260318 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 2 DP - 2026 Feb TI - A Quantitative Text Analysis of the 8050 Problem and Stratified Support in the Japanese Diet. PG - e103557 LID - 10.7759/cureus.103557 [doi] LID - e103557 AB - Introduction The "8050 problem," referring to households where elderly parents in their 80s support socially withdrawn (hikikomori) children in their 50s, presents a critical public health challenge in Japan. To address such complex social isolation, the Japanese government introduced the "Stratified Support System" in 2021. However, there is a concern that bureaucratic framing may obscure the clinical urgency of the issue. This study employs full-population text analysis to objectively quantify the semantic shift in Japanese legislative discourse regarding the 8050 problem, specifically determining whether the 2020 Social Welfare Act amendment drove a transition from clinical terminology to administrative procedural framing. Materials and methods I conducted a comprehensive quantitative text analysis of all minutes from the Japanese National Diet (both the House of Representatives and House of Councillors) over an 11-year period (January 1, 2015, to December 31, 2025). Utilizing the National Diet Library Application Programming Interface (NDL API) to eliminate selection bias, I targeted the entire population of parliamentary statements in Japan. I employed Python-based (Python Software Foundation, Wilmington, DE) natural language processing (NLP) with the morphological analyzer "Janome." I performed a time-series analysis of keyword frequency and co-occurrence network analysis to visualize the semantic structure of policy debates, ensuring their high reproducibility. Results Time-series analysis revealed a significant paradigm shift: mentions of "hikikomori" (clinical reality) peaked in 2019 but diminished significantly after 2020. Conversely, mentions of "Stratified Support" (administrative logic) surged after the 2020 Social Welfare Act amendment. The co-occurrence analysis of the new system's discourse demonstrated a dominance of procedural terms such as "cooperation," "consultation," and "system." Notably, outcome-oriented terms related to clinical recovery or the direct resolution of isolation were scarce compared to administrative process terminology. Conclusions Legislative discourse on social withdrawal has shifted from clinical realities to administrative coordination. This "depersonalization" of policy language may risk prioritizing institutional maintenance over the direct resolution of social determinants of health (SDOH). While administrative integration is necessary, the findings suggest a potential disconnect between policy frameworks and the lived experiences of vulnerable populations. API-based full-text analysis serves as a vital objective tool for monitoring structural shifts in public health policy. CI - Copyright (c) 2026, Sakai et al. FAU - Sakai, Takao AU - Sakai T AD - Orthopedics, Nagoya Kyoritsu Byoin, Nagoya, JPN. LA - eng PT - Journal Article DEP - 20260213 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12989311 OTO - NOTNLM OT - 8050 problem OT - hikikomori OT - japanese health policy OT - natural language processing (nlp) OT - quantitative text analysis OT - social determinants of health (sdoh) COIS- Human subjects: All authors have confirmed that this study did not involve human participants or tissue. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/03/18 07:25 MHDA- 2026/03/18 07:26 PMCR- 2026/02/13 CRDT- 2026/03/18 04:34 PHST- 2026/02/13 00:00 [accepted] PHST- 2026/03/18 07:26 [medline] PHST- 2026/03/18 07:25 [pubmed] PHST- 2026/03/18 04:34 [entrez] PHST- 2026/02/13 00:00 [pmc-release] AID - 10.7759/cureus.103557 [doi] PST - epublish SO - Cureus. 2026 Feb 13;18(2):e103557. doi: 10.7759/cureus.103557. eCollection 2026 Feb. PMID- 41845508 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260627 LR - 20260813 IS - 2052-1847 (Print) IS - 2052-1847 (Electronic) IS - 2052-1847 (Linking) VI - 18 IP - 1 DP - 2026 Mar 17 TI - Ultrasonography is a reliable clinical method for assessing biological maturation. LID - 10.1186/s13102-026-01649-1 [doi] LID - 176 AB - BACKGROUND: Accurate assessment of biological maturity (BM) is essential in pediatric sports medicine to support individualized training and injury prevention. Traditional methods, such as sexual maturity ratings (SMR) and radiographic imaging, have limitations including subjectivity, discomfort, and radiation exposure. This study aimed to evaluate and validate the use of two established ultrasonography protocols for assessing biological maturity at the tibial tuberosity in healthy, physically active youth. METHODS: Seventy-three children and adolescents (41 boys, 32 girls; mean age 13.4 years) were recruited from schools in Northern Sweden. BM was assessed using SMR and two established ultrasonographic protocols (Sailly and Kijima). Validity was evaluated using Spearman's rho, and inter- and intrarater reliability were assessed with Cohen's weighted kappa. RESULTS: Ultrasonographic assessments showed strong agreement with SMR-based evaluations. Interrater reliability was substantial for both methods (kappa = 0.761-0.814, p < 0.001). The method proved feasible for use by trained physiotherapists and did not require radiological or endocrinological expertise. CONCLUSION: Ultrasonography, combined with anthropometric data, is a valid, reliable, and practical alternative for assessing BM in youth. Its non-invasive, radiation-free nature and scalability make it particularly suitable for pediatric and sports settings. Further research should explore its application in diverse populations and its role in guiding biologically informed training strategies. FAU - Sundell, Claes Goran AU - Sundell CG AD - Department of Community Medicine and Rehabilitation, Sports medicine, Umea University, Umea, Sweden. claes-goran.sundell@umu.se. FAU - Theos, Apostolos AU - Theos A AD - Department of Community Medicine and Rehabilitation, Sports medicine, Umea University, Umea, Sweden. AD - Umea School of Sport Sciences, Umea University, Umea, Sweden. FAU - Lindberg, Ann-Sofie AU - Lindberg AS AD - Department of Health, Education and Technology, Lulea University of Technology, Lulea, Sweden. FAU - Rullander, Anna-Clara AU - Rullander AC AD - Department of Nursing, Umea University, Umea, Sweden. FAU - Lundberg, Elena AU - Lundberg E AD - Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden. LA - eng PT - Journal Article DEP - 20260317 PL - England TA - BMC Sports Sci Med Rehabil JT - BMC sports science, medicine & rehabilitation JID - 101605016 PMC - PMC13064236 OTO - NOTNLM OT - Adolescent OT - Child OT - Growth and Maturation OT - Sports Medicine OT - Tibial Tuberosity COIS- Declarations. Ethics approval and consent to participate: Written informed consent was obtained from the children and the legal guardians/parents after information about the study. The study was approved by the Swedish Ethical Review Authority (EPM DNR: Dnr 2023-00341-01) and was conducted in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/18 07:25 MHDA- 2026/03/18 07:26 PMCR- 2026/03/17 CRDT- 2026/03/18 00:57 PHST- 2025/08/25 00:00 [received] PHST- 2026/03/06 00:00 [accepted] PHST- 2026/03/18 07:26 [medline] PHST- 2026/03/18 07:25 [pubmed] PHST- 2026/03/18 00:57 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - 10.1186/s13102-026-01649-1 [pii] AID - 1649 [pii] AID - 10.1186/s13102-026-01649-1 [doi] PST - epublish SO - BMC Sports Sci Med Rehabil. 2026 Mar 17;18(1):176. doi: 10.1186/s13102-026-01649-1. PMID- 41845482 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260627 LR - 20260813 IS - 1751-0759 (Print) IS - 1751-0759 (Electronic) IS - 1751-0759 (Linking) VI - 20 IP - 1 DP - 2026 Mar 18 TI - Pediatric scurvy and eating disorders: the feasibility of a tasteless, odorless multiple-micronutrient powder for avoidance of tube feeding. LID - 10.1186/s13030-026-00351-5 [doi] LID - 7 AB - BACKGROUND: Scurvy has re-emerged in association with neurodevelopmental and eating disorders, particularly selective eating. This study aimed to investigate the clinical characteristics of pediatric scurvy cases. METHODS: We retrospectively assessed the data of pediatric patients diagnosed with scurvy at a Japanese medical institution between 2017 and 2023. Clinical characteristics, nutritional profiles, and treatment outcomes were analyzed. RESULTS: In total, 13 children, median age 52 months, had scurvy, 92% of whom had confirmed or suspected autism spectrum disorder; all were diagnosed with an eating disorder. All children also had low serum vitamin C levels, and 85% exhibited multiple nutrient deficiencies. Common symptoms included gait disturbances (85%), joint pain (69%), and fever (46%). Eight patients (62%) were misdiagnosed by their previous doctor. In the acute phase, the median symptom resolution time was 10 days by administration of vitamin C. In the chronic phase, despite nutritional counseling and education, none of the patients were able to consume enough vitamin C by food, and the prescribed vitamin formulation was not taken in 4 of 9 patients (44%) owing to hypersensitivity. Treatment with odorless, tasteless, multiple-micronutrient supplements containing vitamin C was successful in all 11 patients who attempted it. CONCLUSIONS: All cases of pediatric scurvy in this cohort were caused by an eating disorder, neurodevelopmental disorder, physical disease, or a combination thereof. The diverse clinical course and misdiagnosis in some cases underscore the importance of a detailed dietary history for diagnosis. In terms of treatment, all patients in this study had very limited oral food owing to autism, but none required tube feeding, indicating that tasteless, odorless, multiple-micronutrient supplement powders might be beneficial in reducing the need for tube feeding in children who cannot take the prescribed vitamin formulation orally. FAU - Saito, Tomoki AU - Saito T AD - Department of General Pediatrics, Hyogo Prefectural Kobe Children's Hospital, 1-6-7 Minatojima Minamicho, Chuo-ku, Kobe, Hyogo, 650- 0047, Japan. t.saito.rq@gmail.com. FAU - Minamikawa, Shogo AU - Minamikawa S AD - Department of General Pediatrics, Hyogo Prefectural Kobe Children's Hospital, 1-6-7 Minatojima Minamicho, Chuo-ku, Kobe, Hyogo, 650- 0047, Japan. FAU - Okazaki, Sayaka AU - Okazaki S AD - Department of General Pediatrics, Hyogo Prefectural Kobe Children's Hospital, 1-6-7 Minatojima Minamicho, Chuo-ku, Kobe, Hyogo, 650- 0047, Japan. FAU - Tomioka, Kazumi AU - Tomioka K AD - Department of General Pediatrics, Hyogo Prefectural Kobe Children's Hospital, 1-6-7 Minatojima Minamicho, Chuo-ku, Kobe, Hyogo, 650- 0047, Japan. tomioka@med.kobe-u.ac.jp. FAU - Mizuta, Mao AU - Mizuta M AD - Department of General Pediatrics, Hyogo Prefectural Kobe Children's Hospital, 1-6-7 Minatojima Minamicho, Chuo-ku, Kobe, Hyogo, 650- 0047, Japan. FAU - Saito, Atsuro AU - Saito A AD - Department of Hematology and Oncology, Hyogo Prefectural Kobe Children's Hospital, 1-6-7 Minatojima Minamicho, Chuo-ku, Kobe, Hyogo, 650-0047, Japan. FAU - Nakagishi, Yasuo AU - Nakagishi Y AD - Department of General Pediatrics, Hyogo Prefectural Kobe Children's Hospital, 1-6-7 Minatojima Minamicho, Chuo-ku, Kobe, Hyogo, 650- 0047, Japan. LA - eng PT - Journal Article DEP - 20260318 PL - England TA - Biopsychosoc Med JT - BioPsychoSocial medicine JID - 101286572 PMC - PMC13112992 OTO - NOTNLM OT - Autism spectrum disorder OT - Complementary feeding OT - Eating disorders OT - Scurvy OT - Vitamin C COIS- Declarations. Ethics approval and consent to participate: The secondary use of clinical information in this study was approved by the Ethics Committee of the Hyogo Prefectural Kobe Children's Hospital (Ethics Review Number R6-69). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/18 07:25 MHDA- 2026/03/18 07:26 PMCR- 2026/03/18 CRDT- 2026/03/18 00:56 PHST- 2025/07/07 00:00 [received] PHST- 2026/01/22 00:00 [accepted] PHST- 2026/03/18 07:26 [medline] PHST- 2026/03/18 07:25 [pubmed] PHST- 2026/03/18 00:56 [entrez] PHST- 2026/03/18 00:00 [pmc-release] AID - 10.1186/s13030-026-00351-5 [pii] AID - 351 [pii] AID - 10.1186/s13030-026-00351-5 [doi] PST - epublish SO - Biopsychosoc Med. 2026 Mar 18;20(1):7. doi: 10.1186/s13030-026-00351-5. PMID- 41845467 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1460-2237 (Electronic) IS - 0268-1080 (Print) IS - 0268-1080 (Linking) VI - 41 IP - 5 DP - 2026 May 20 TI - WHO guidelines on physical activity, sedentary behaviour, and sleep for children under 5: a qualitative study of Mongolian stakeholder perceptions. PG - 809-820 LID - 10.1093/heapol/czag037 [doi] AB - WHO's '24-hour movement guidelines' provide integrated recommendations for physical activity, sedentary behaviour, and sleep to improve health outcomes in children aged 0-5. This study aimed to examine stakeholders' perceptions about these guidelines to inform its future adoption, adaptation, and implementation decisions in Mongolia. Key stakeholders involved in young children's health and development were recruited through purposive sampling and snowball methods. Semi-structured interviews spanning 30-50 minutes were conducted with 38 participants using an interview guide in Mongolian language: caregivers (n = 19), kindergarten teachers (n = 14), health and policy professionals (n = 5). Audio-recorded data were transcribed, translated to English, and thematically analysed using deductive thematic analysis. Four main themes were identified: (i) awareness and appropriateness, (ii) understanding of the guidelines, (iii) perceived factors influencing adoption and implementation, and (iv) dissemination and implementation strategies. Stakeholders were mostly unaware of the WHO guidelines but perceived them as useful, feasible and culturally appropriate. Stakeholders identified barriers including competing priorities (e.g. work/family obligations), environmental challenges (lack of child-friendly spaces, cold weather, air pollution), and knowledge and capacity gaps. Stakeholder-recommended strategies for effective dissemination and implementation were kindergarten-based integration, training for caregivers and teachers, and adequate resource provision. Dissemination should use multichannel communication approaches emphasizing benefits, potential consequences of non-adherence, and provide specific, culturally relevant examples. This study provides first examination of stakeholder perspectives on WHO 24-hour movement guidelines in Central Asia. These preliminary findings suggest that successful adoption may require cultural adaptation, stakeholder education, and leveraging existing infrastructure and policy frameworks, though education sector consultation would be needed for comprehensive feasibility assessment. CI - (c) The Author(s) 2026. Published by Oxford University Press in association with The London School of Hygiene and Tropical Medicine. FAU - Byambaa, Ankhmaa AU - Byambaa A AUID- ORCID: 0000-0003-2504-0239 AD - Nutrition Department, National Centre for Public Health, 17 Peace Avenue, Ulaanbaatar 13381, Mongolia. AD - School of Medical, Indigenous and Health Sciences, Faculty of Science, Medicine and Health, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia. FAU - Jones, Rachel A AU - Jones RA AUID- ORCID: 0000-0002-5384-1941 AD - School of Education, Faculty of Arts, Society and Business, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia. FAU - Okely, Anthony D AU - Okely AD AUID- ORCID: 0000-0002-1626-8170 AD - School of Medical, Indigenous and Health Sciences, Faculty of Science, Medicine and Health, University of Wollongong, Northfields Avenue, Wollongong, NSW 2522, Australia. LA - eng PT - Journal Article PL - England TA - Health Policy Plan JT - Health policy and planning JID - 8610614 SB - IM MH - Humans MH - Child, Preschool MH - Mongolia MH - Qualitative Research MH - Female MH - *Sedentary Behavior MH - Male MH - *Sleep MH - *Exercise MH - Infant MH - *Guidelines as Topic MH - Interviews as Topic MH - Stakeholder Participation MH - Caregivers PMC - PMC13187624 OTO - NOTNLM OT - LMIC OT - early childhood OT - guidelines OT - implementation barriers OT - movement behaviours COIS- Conflicts of interest: None declared. EDAT- 2026/03/18 07:25 MHDA- 2026/05/20 06:31 PMCR- 2026/03/17 CRDT- 2026/03/18 00:55 PHST- 2026/03/11 00:00 [accepted] PHST- 2026/05/20 06:31 [medline] PHST- 2026/03/18 07:25 [pubmed] PHST- 2026/03/18 00:55 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - 8527030 [pii] AID - czag037 [pii] AID - 10.1093/heapol/czag037 [doi] PST - ppublish SO - Health Policy Plan. 2026 May 20;41(5):809-820. doi: 10.1093/heapol/czag037. PMID- 41845068 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20261010 IS - 1437-1596 (Electronic) IS - 0937-9827 (Linking) VI - 140 IP - 4 DP - 2026 Jul TI - Automated Dental Age Estimation from Panoramic Radiographs using an Interpretable Deep Learning Model. PG - 2237-2246 LID - 10.1007/s00414-026-03748-7 [doi] AB - Dental age estimation serves as a crucial foundation for forensic identification and pediatric dental assessment. Yet traditional methods, including the Demirjian and Willems standards, depend on subjective staging of tooth mineralization, resulting in observer variability and reduced applicability in routine practice. We developed an interpretable deep learning model trained on 7,207 panoramic radiographs from individuals aged 3.00-14.99 years. In five-fold cross-validation, the model achieved a mean absolute error (MAE) of 0.67 years, a root mean squared error (RMSE) of 0.87 years, and an R(2) of 0.92, outperforming benchmark deep architectures. Compared with expert assessments, the model yielded lower MAEs (0.78 vs. 0.92 years) and markedly shortened processing time. To enhance clinical reliability, the model self-assesses its confidence for each estimation, providing a predictive range. The 95% prediction intervals with a mean width of 2.76 years and 94.32% coverage. Gradient-weighted Class Activation Mapping confirmed biologically plausible attention to dental regions such as molars and root apices. The proposed model enables accurate, efficient, and interpretable dental age estimation with quantified uncertainty, supporting its potential application in forensic and clinical settings. FAU - Luo, Shuai AU - Luo S AD - College of Computer Science, Sichuan University, Chengdu, Sichuan, 610041, P.R. China. AD - Department of Forensic Pathology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, P.R. China. FAU - Shi, Lei AU - Shi L AD - Shanghai Key Laboratory of Forensic Medicine, Shanghai Forensic Service Platform, Academy of Forensic Science, Ministry of Justice, Shanghai, 200063, China. FAU - Liu, Meng AU - Liu M AD - College of Computer Science, Sichuan University, Chengdu, Sichuan, 610041, P.R. China. AD - Department of Forensic Pathology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, P.R. China. FAU - Sun, Yu-Xiao AU - Sun YX AD - Department of Forensic Pathology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, P.R. China. FAU - Yang, Hui-Kun AU - Yang HK AD - Department of Forensic Pathology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, P.R. China. FAU - Qiu, Li-Rong AU - Qiu LR AD - Department of Forensic Pathology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, P.R. China. FAU - Zhou, Yu-Chi AU - Zhou YC AD - Department of Forensic Pathology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, P.R. China. FAU - Fan, Fei AU - Fan F AD - Department of Forensic Pathology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, P.R. China. FAU - Zhang, Di-Wen AU - Zhang DW AD - Third Peoples Hospital of Mianyang, Mianyang, Sichuan, 612000, China. FAU - Deng, Zhen-Hua AU - Deng ZH AD - Department of Forensic Pathology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, P.R. China. dengzhenhua@scu.edu.cn. FAU - Chen, Hu AU - Chen H AD - College of Computer Science, Sichuan University, Chengdu, Sichuan, 610041, P.R. China. huchen@scu.edu.cn. FAU - Zhan, Meng-Jun AU - Zhan MJ AD - Department of Forensic Pathology, West China School of Basic Medical Sciences & Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041, P.R. China. zhanmengjun@scu.edu.cn. LA - eng GR - 2024NSFSC1517/Natural Science Foundation of Sichuan Province/ PT - Journal Article DEP - 20260318 PL - Germany TA - Int J Legal Med JT - International journal of legal medicine JID - 9101456 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - *Radiography, Panoramic MH - *Deep Learning MH - Child MH - Child, Preschool MH - Adolescent MH - Reproducibility of Results MH - Forensic Dentistry OTO - NOTNLM OT - Dental age estimation OT - Forensic anthropology OT - Grad-CAM OT - Interpretable deep learning OT - Panoramic radiographs COIS- Declarations. Consent to publish: Not applicable. Conflict of interest: Authors declare no competing interests. Compliance with ethical standards: Ethical approval was granted by the ethics committee of Sichuan University (NO. K2019047). The requirement for written informed consent was waived by the ethics committee due to the retrospective nature of the study. EDAT- 2026/03/18 07:25 MHDA- 2026/06/28 00:37 CRDT- 2026/03/18 00:31 PHST- 2025/12/15 00:00 [received] PHST- 2026/02/13 00:00 [accepted] PHST- 2026/06/28 00:37 [medline] PHST- 2026/03/18 07:25 [pubmed] PHST- 2026/03/18 00:31 [entrez] AID - 10.1007/s00414-026-03748-7 [pii] AID - 10.1007/s00414-026-03748-7 [doi] PST - ppublish SO - Int J Legal Med. 2026 Jul;140(4):2237-2246. doi: 10.1007/s00414-026-03748-7. Epub 2026 Mar 18. PMID- 41844744 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 17 TI - Diverse and rare candidate MODY gene variants were identified in one-fifth of a Bangladeshi cohort with nonobese, nonautoimmune youth-onset diabetes. LID - 10.1038/s41598-026-43760-w [doi] LID - 13853 AB - The global distribution and frequency of maturity onset diabetes of the young (MODY) vary, necessitating investigation across diverse ethnic groups. This study aimed to investigate MODY gene variants and phenotypic characteristics among young Bangladeshi individuals with nonobese, nonautoimmune youth-onset diabetes. Fifty participants with diabetes (onset < 35 years, BMI < 25 kg/m(2), negative for islet autoantibodies, detectable C-peptide, and a family history of DM) and 50 young individuals with normoglycemia were enrolled. Targeted next-generation sequencing (NGS) was performed on a panel of 14 known MODY genes. Candidate MODY-gene variants were identified in 20% (10/50) of the diabetes cohort. There were 11 heterozygous missense variants across eight genes: HNF1A, PDX1, NEUROD1, KLF11, PAX4 (three variants), BLK, ABCC8 (two variants), and KCNJ11. No variants met the ACMG/AMP criteria for 'Pathogenic' or 'Likely Pathogenic' classification; all identified variants were categorized as variants of uncertain significance (VUS). No significant phenotypic differences were observed between individuals with diabetes who carried identified variants and those who did not. In conclusion, this study identified candidate MODY variants (all classified as VUS) in one-fifth of the Bangladeshi nonobese, nonautoimmune youth-onset diabetes cohort. These findings provide a preliminary indication of a distinct genetic pattern characterized by a low frequency of common variants and a relative abundance of variants in rare MODY-associated genes. These findings are hypothesis-generating and highlight potential genetic targets for future functional validation to confirm pathogenicity and to support definitive MODY diagnoses. FAU - Hasan, Mashfiqul AU - Hasan M AUID- ORCID: 0000-0002-1805-5187 AD - Department of Endocrinology, Bangladesh Medical University, Shahbag, Dhaka, 1000, Bangladesh. mashfiqul.phd.m22@bsmmu.edu.bd. FAU - Sultana, Nusrat AU - Sultana N AUID- ORCID: 0000-0002-6858-2110 AD - Department of Endocrinology, Bangladesh Medical University, Shahbag, Dhaka, 1000, Bangladesh. FAU - Shil, Kishore Kumar AU - Shil KK AUID- ORCID: 0000-0002-6664-6408 AD - Department of Endocrinology, Bangladesh Medical University, Shahbag, Dhaka, 1000, Bangladesh. FAU - Abdus-Salam, Sayad Bin AU - Abdus-Salam SB AUID- ORCID: 0000-0001-8195-4903 AD - Department of Endocrinology, Bangladesh Medical University, Shahbag, Dhaka, 1000, Bangladesh. FAU - Nayem, Maksudur Rahman AU - Nayem MR AUID- ORCID: 0009-0006-9943-4838 AD - DNA Solutions Ltd, Dhaka, 1207, Bangladesh. FAU - Oliver, Merina AU - Oliver M AD - Med Genome Labs, Bangalore, 560099, India. FAU - Padinjyarekara, Aswathi AU - Padinjyarekara A AD - Med Genome Labs, Bangalore, 560099, India. FAU - Golani, Tamanna AU - Golani T AD - Med Genome Labs, Bangalore, 560099, India. FAU - Rabbi, Mohammad Fazle Alam AU - Rabbi MFA AUID- ORCID: 0000-0002-2017-9680 AD - Department of Soil, Water and Environment, University of Dhaka, Dhaka, 1000, Bangladesh. FAU - Salimullah, Md AU - Salimullah M AD - Molecular Biotechnology Division, National Institute of Biotechnology, Savar, Dhaka, Bangladesh. FAU - Akhteruzzaman, Sharif AU - Akhteruzzaman S AD - Department of Genetic Engineering and Biotechnology, University of Dhaka, Dhaka, 1000, Bangladesh. FAU - Hasanat, Muhammad Abul AU - Hasanat MA AUID- ORCID: 0000-0001-8151-9792 AD - Department of Endocrinology, Bangladesh Medical University, Shahbag, Dhaka, 1000, Bangladesh. LA - eng GR - BSMMU/2023/13314(6)/Bangladesh Medical University/ GR - BMRC/Revenue/Research Grant/2025/189(1-68)/Bangladesh Medical Research Council/ PT - Journal Article DEP - 20260317 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Potassium Channels, Inwardly Rectifying) RN - 0 (Kcnj11 Channel) RN - 0 (Homeodomain Proteins) RN - 0 (pancreatic and duodenal homeobox 1 protein) RN - 0 (NEUROD1 protein, human) RN - 0 (Hepatocyte Nuclear Factor 1-alpha) RN - 0 (Basic Helix-Loop-Helix Proteins) RN - 0 (PAX4 protein, human) RN - 0 (HNF1A protein, human) RN - 0 (ABCC8 protein, human) RN - 0 (Sulfonylurea Receptors) RN - 0 (Paired Box Transcription Factors) RN - 0 (Trans-Activators) RN - Mason-Type Diabetes SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/genetics/epidemiology MH - Female MH - Male MH - Bangladesh/epidemiology MH - Adolescent MH - Adult MH - Potassium Channels, Inwardly Rectifying/genetics MH - Kcnj11 Channel MH - Homeodomain Proteins/genetics MH - Hepatocyte Nuclear Factor 1-alpha/genetics MH - Basic Helix-Loop-Helix Proteins/genetics MH - Young Adult MH - Cohort Studies MH - Sulfonylurea Receptors/genetics MH - High-Throughput Nucleotide Sequencing MH - Paired Box Transcription Factors/genetics MH - Trans-Activators/genetics MH - Genetic Predisposition to Disease MH - Age of Onset MH - *Genetic Variation MH - Child MH - Phenotype PMC - PMC13128926 OTO - NOTNLM OT - Bangladesh OT - Diabetes mellitus OT - Genetic variation OT - Maturity onset diabetes of the young COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/03/18 07:25 MHDA- 2026/06/27 12:36 PMCR- 2026/03/17 CRDT- 2026/03/18 00:22 PHST- 2025/12/04 00:00 [received] PHST- 2026/03/06 00:00 [accepted] PHST- 2026/06/27 12:36 [medline] PHST- 2026/03/18 07:25 [pubmed] PHST- 2026/03/18 00:22 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - 10.1038/s41598-026-43760-w [pii] AID - 43760 [pii] AID - 10.1038/s41598-026-43760-w [doi] PST - epublish SO - Sci Rep. 2026 Mar 17;16(1):13853. doi: 10.1038/s41598-026-43760-w. PMID- 41844700 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 17 TI - AI-powered ultrasound radiofrequency analysis for non-invasive pediatric liver fat quantification. LID - 10.1038/s41598-026-37862-8 [doi] LID - 13798 AB - Metabolic dysfunction-Associated Steatotic Liver Disease (MASLD) affects 30-50% of obese children, yet accurate non-invasive quantification remains challenging. While magnetic resonance imaging-proton density fat fraction (MRI-PDFF) represents the reference standard, its limited accessibility necessitates alternative approaches. Forty pediatric patients (age 12.16 +/- 2.56 years) referred for MASLD were prospectively enrolled for same-day ultrasound radiofrequency (RF) data acquisition and MRI-PDFF examination. Two artificial intelligence (AI) approaches using multiple input combinations of RF data, ultrasound-guided attenuation parameters (UGAP), and clinical parameters were developed for non-invasive pediatric liver fat quantification: radiomics-based models and deep learning models. The best radiomics model (XGBoost) and the best deep learning model (Mod-MHDNet) achieved optimal performance with multimodal inputs (R2 = 0.81 and 0.76, respectively). Bland-Altman analysis demonstrated excellent agreement with MRI-PDFF, with a mean bias of < 0.4% points for both approaches. AI analysis of ultrasound RF data enables accurate and accessible quantification of pediatric liver fat, offering a practical alternative for MASLD evaluation. FAU - Choi, Gayoung AU - Choi G AD - Department of Radiology, Korea University College of Medicine, Korea University Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Ansan-si, Gyeonggi-do, 15355, Republic of Korea. FAU - Ham, Sungwon AU - Ham S AD - Healthcare Readiness Institute for Unified Korea, Korea University College of Medicine, Korea University Ansan Hospital, Ansan-si, Gyeonggi-do, 15355, Republic of Korea. FAU - Je, Bo-Kyung AU - Je BK AD - Department of Radiology, Korea University College of Medicine, Korea University Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Ansan-si, Gyeonggi-do, 15355, Republic of Korea. radje@korea.ac.kr. FAU - Shin, Minsoo AU - Shin M AD - Department of Pediatrics, Korea University Ansan Hospital, Ansan-si, Gyeonggi-do, 15355, Republic of Korea. LA - eng GR - K2409221, O2310661/Korea University Medicine/ PT - Journal Article DEP - 20260317 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Child MH - Ultrasonography/methods MH - Female MH - *Liver/diagnostic imaging/pathology MH - Male MH - Magnetic Resonance Imaging MH - Adolescent MH - *Artificial Intelligence MH - *Fatty Liver/diagnostic imaging MH - Radiomics MH - Prospective Studies MH - *Adipose Tissue/diagnostic imaging PMC - PMC13128852 OTO - NOTNLM OT - Magnetic resonance imaging OT - Metabolic dysfunction-associated steatotic liver disease OT - Pediatric obesity OT - Ultrasonography COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/03/18 07:25 MHDA- 2026/06/28 16:09 PMCR- 2026/03/17 CRDT- 2026/03/18 00:20 PHST- 2025/10/10 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/06/28 16:09 [medline] PHST- 2026/03/18 07:25 [pubmed] PHST- 2026/03/18 00:20 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - 10.1038/s41598-026-37862-8 [pii] AID - 37862 [pii] AID - 10.1038/s41598-026-37862-8 [doi] PST - epublish SO - Sci Rep. 2026 Mar 17;16(1):13798. doi: 10.1038/s41598-026-37862-8. PMID- 41843828 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260902 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Mar 17 TI - Molecular and Pharmacogenetic Marker Evaluation in Relation to the Toxicity and Clinical Response of Acute Lymphoblastic Leukemia Treatment in Indian Children (MPGx-INDALL): Protocol for a Prospective Observational Cohort Study. PG - e79865 LID - 10.2196/79865 [doi] LID - e79865 AB - BACKGROUND: Understanding interindividual variability in treatment response and toxicity is essential for optimizing outcomes in pediatric acute lymphoblastic leukemia (ALL). Molecular and pharmacogenetic markers hold promise in predicting treatment efficacy and adverse effects, particularly in genetically diverse populations. This protocol outlines the methodology for a prospective, nonrandomized observational cohort designed to evaluate molecular and pharmacogenetic factors associated with treatment response and toxicity in Indian children diagnosed with ALL. OBJECTIVE: The primary objective is to identify genetic markers associated with treatment-related toxicity and therapeutic response. Secondary objectives include evaluating associations between the occurrence of early toxicities and quality of life during active ALL treatment, specific pharmacogenetic variants, and survival outcomes along with generating data to support the future implementation of personalized treatment strategies in Indian children with ALL. METHODS: In this prospective, observational cohort, 556 children (6 months) and tissue transglutaminase immunoglobulin A (tTG-IgA) levels. Diagnostic performance was determined using receiver operating characteristic (ROC) curves. RESULTS: Mesenteric and ileal SWE values were significantly higher in CD patients than controls (p < 0.001 for both). Mesenteric stiffness demonstrated an area under the ROC curve (AUC) of 0.81 with an optimal cut-off of 9.03 kPa, while ileal stiffness showed an AUC of 0.83 with a cut-off of 9.71 kPa. Subgroup analysis revealed no significant difference in baseline Marsh scores between the short-term and long-term GFD groups (p = 0.305), despite a dramatic decline in tTG-IgA levels in the long-term group (p < 0.001). Elevated stiffness persisted in both newly diagnosed and GFD-treated patients compared with controls (all p < 0.001). No significant correlations were observed between SWE values and concurrent tTG-IgA levels or Marsh subtypes (all p > 0.05). CONCLUSION: Increased mesenteric and ileal stiffness in children with CD likely reflect transmural involvement and structural remodeling beyond the mucosal injury. These findings demonstrate that SWE has good diagnostic utility and may serve as a valuable complementary noninvasive tool in the evaluation and clinical monitoring of pediatric CD. CI - (c) 2026 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Ergen, Yasin Maruf AU - Ergen YM AUID- ORCID: 0000-0002-3689-6852 AD - Department of Pediatrics/Division of Pediatric Gastroenterology, Gulhane Training and Research Hospital, Ankara, Turkey. FAU - Cavis, Tugba AU - Cavis T AUID- ORCID: 0000-0001-8878-9568 AD - Department of Radiology, Gulhane Training and Research Hospital, Ankara, Turkey. FAU - Teke, Selcuk AU - Teke S AUID- ORCID: 0000-0002-1885-6611 AD - Department of Pediatrics/Division of Pediatric Gastroenterology, Gulhane Training and Research Hospital, Ankara, Turkey. FAU - Basaran, Edibe Gozde AU - Basaran EG AUID- ORCID: 0000-0003-3165-3234 AD - Department of Pediatrics/Division of Pediatric Gastroenterology, Gulhane Training and Research Hospital, Ankara, Turkey. FAU - Akcay, Birce Izgi AU - Akcay BI AUID- ORCID: 0000-0002-1325-0899 AD - Department of Pediatrics/Division of Pediatric Gastroenterology, Gulhane Training and Research Hospital, Ankara, Turkey. FAU - Balamtekin, Necati AU - Balamtekin N AUID- ORCID: 0000-0001-8665-5611 AD - Department of Pediatrics/Division of Pediatric Gastroenterology, Gulhane Training and Research Hospital, Ankara, Turkey. LA - eng GR - None/ PT - Journal Article DEP - 20260316 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 RN - 0 (Immunoglobulin A) SB - IM MH - Humans MH - *Elasticity Imaging Techniques/methods MH - *Celiac Disease/diagnostic imaging/pathology/diet therapy MH - Male MH - Female MH - Child MH - Prospective Studies MH - *Ileum/diagnostic imaging/pathology MH - Adolescent MH - ROC Curve MH - Child, Preschool MH - *Mesentery/diagnostic imaging/pathology MH - Diet, Gluten-Free MH - Case-Control Studies MH - Severity of Illness Index MH - Immunoglobulin A/blood OTO - NOTNLM OT - bowel stiffness OT - gluten-free diet OT - mesenteric assessment OT - pediatrics OT - terminal ileum EDAT- 2026/03/17 06:48 MHDA- 2026/06/12 00:38 CRDT- 2026/03/17 01:43 PHST- 2026/01/11 00:00 [revised] PHST- 2025/12/04 00:00 [received] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/06/12 00:38 [medline] PHST- 2026/03/17 06:48 [pubmed] PHST- 2026/03/17 01:43 [entrez] AID - 10.1002/jpn3.70400 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Jun;82(6):1458-1465. doi: 10.1002/jpn3.70400. Epub 2026 Mar 16. PMID- 41840702 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260901 IS - 2046-4053 (Electronic) IS - 2046-4053 (Linking) VI - 15 IP - 1 DP - 2026 Mar 17 TI - Chatbot-based interventions for improvement of diet, physical activity, and tobacco use behaviors: protocol for a systematic review. LID - 10.1186/s13643-026-03154-5 [doi] LID - 142 AB - BACKGROUND: This systematic review aims to summarize the effectiveness, acceptability, and potential mechanisms of chatbot-based interventions in improving diet, physical activity, and tobacco use behaviors. METHODS: This protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P). We will include individual- or cluster-randomized, parallel-group controlled trials that compare chatbot-based interventions with active-control, waiting-list, or usual-control comparators among children, adults, and the elderly irrespective of their behavioral patterns at baseline. We will also include the non-randomized or single-group trials to expand the evidence base. The primary outcomes will be the change in diet, physical activity, and tobacco use behaviors assessed by validated questionnaires or objective measures. The secondary outcomes will include the change in obesity-related outcomes, stage of behavioral change, change of motivation, emotion, knowledge, or other constructs that might mediate the intervention effect, chatbot use behaviors during the process of intervention implementation, the facilitators and barriers to chatbot use, and safety issues. We will search both the studies published in PubMed, EMBASE, ACM Digital Library, Web of Science, PsycINFO, CINAHL, and IEEE and the unpublished studies in the WHO's International Clinical Trials Registry Platform, ClinicalTrials.gov, conference proceedings, GitHub, and arXiv. We will group the included studies based on their consistency in the Population, Intervention, Comparator, Outcome and Study design (PICOS) elements for data synthesis. The random-effects meta-analysis will be used to quantitatively synthesize the results across studies if data permits; otherwise, we will synthesize the study results based on the guideline of Synthesis Without Meta-analysis (SWiM). We will use the correlation-based meta-analytical structural equation modeling approach to examine the presence of mediators of chatbot-based interventions. We will assess the risk of bias for each included study using the revised version of the Cochrane risk-of-bias tool for randomized trials (RoB 2) or the Risk of Bias In Non-randomized Studies of Interventions (ROBINS-I), and appraise the certainty of the evidence for each synthesized result using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach. DISCUSSION: This systematic review will not only answer whether the state-of-the-art chatbot-based interventions are acceptable and effective in changing a person's diet, physical activity, and tobacco use behaviors but also explore the potential mechanisms underlying the effects of the chatbot-based interventions. The findings of this study will pave the way for optimizing future chatbot-based interventions in the field of health-related behaviors. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42023492013. CI - (c) 2026. The Author(s). FAU - Liu, Zheng AU - Liu Z AUID- ORCID: 0000-0002-0405-2348 AD - Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China. liuzheng@bjmu.edu.cn. FAU - Yang, Yang AU - Yang Y AD - Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China. FAU - Chen, Jing AU - Chen J AD - Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China. FAU - Zhang, Shang-Hang AU - Zhang SH AD - National Key Laboratory for Multimedia Information Processing, School of Computer Science, Peking University, Beijing, China. FAU - Zhang, Xiao-Rui AU - Zhang XR AD - Department of Pediatric, Peking University People's Hospital, Beijing, China. FAU - Zhuang, Yu-Xuan AU - Zhuang YX AD - Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China. FAU - Hu, Run-Ze AU - Hu RZ AD - Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, 100191, China. LA - eng GR - BECA23111/Beijing Education Sciences Planning Program during the 14th Five-Year Plan/ GR - 2023QNRC001/Young Elite Scientists Sponsorship Program by CAST/ GR - 82373694/National Natural Science Foundation of China/ PT - Journal Article DEP - 20260317 PL - England TA - Syst Rev JT - Systematic reviews JID - 101580575 SB - IM MH - Humans MH - Systematic Reviews as Topic MH - *Exercise MH - *Diet MH - *Tobacco Use/prevention & control MH - *Health Behavior MH - *Health Promotion/methods MH - Research Design PMC - PMC13107892 OTO - NOTNLM OT - Chatbot OT - Diet OT - Intervention OT - Physical activity OT - Systematic review OT - Tobacco use COIS- Declarations. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/03/17 06:47 MHDA- 2026/04/24 06:33 PMCR- 2026/03/17 CRDT- 2026/03/17 01:04 PHST- 2024/04/27 00:00 [received] PHST- 2026/03/07 00:00 [accepted] PHST- 2026/04/24 06:33 [medline] PHST- 2026/03/17 06:47 [pubmed] PHST- 2026/03/17 01:04 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - 10.1186/s13643-026-03154-5 [pii] AID - 3154 [pii] AID - 10.1186/s13643-026-03154-5 [doi] PST - epublish SO - Syst Rev. 2026 Mar 17;15(1):142. doi: 10.1186/s13643-026-03154-5. PMID- 41840697 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Mar 16 TI - Exercise motivation patterns in emerging adults: dual roles of weight and shape concern in activation and inhibition pathways. LID - 10.1186/s40359-026-04366-z [doi] LID - 597 AB - BACKGROUND: Exercise motivation constitutes a key determinant of physical activity(PA). However, prior research has predominantly adopted a variable-centered approach, thereby overlooking the coexistence of multiple motivational goals within individuals. Moreover, in the context of increasing body image concerns, the relationship between body-related concerns and individuals' patterns of exercise motivation warrants further investigation. The work aimed to assess latent profiles of exercise motivation among Chinese emerging adult males and females, the association of weight and shape concern (WSC) with motivation profiles, and differences in PA across these profiles. METHODS: A total of 2,112 Chinese emerging adults were surveyed using validated instruments measuring exercise motivation, WSC, and PA. Latent profile analysis (LPA) was conducted to identify motivation profiles. Multinomial logistic regression was used to examine associations of WSC with profile membership, with body mass index (BMI) included as a covariate. Differences in PA across profiles were analyzed using one-way ANOVA. RESULTS: LPA identified four profiles in the male sample: low-motivation profile, fitness-oriented profile, moderate low-motivation profile, and high-motivation profile. Five profiles were identified in the female samples: low-motivation profile, moderate low-motivation profile, low social-oriented profile, high-motivation profile, and enjoyment and social-oriented profile. WSC was significantly associated with motivation profile membership. For males, higher WSC was associated with a higher likelihood of classification into the high-motivation profile. For females, however, WSC showed a dual association, associated with a higher likelihood of both the high-motivation and low-motivation or low social-oriented profiles. PA varied significantly across profiles. For males, the high-motivation profile exhibited significantly greater PA than all other profiles. For females, the high-motivation profile demonstrated higher PA levels than the low-, moderate low-, and enjoyment and social-oriented profiles, but did not differ significantly from the low social-oriented profile. CONCLUSIONS: Exercise motivation exhibited significant heterogeneity among emerging adults in China. WSC was significantly associated with profile membership in both males and females. Overall, these findings highlight the importance of considering diverse motivational configurations and body image concerns in efforts to promote physical activity. FAU - Wu, Jiahao AU - Wu J AD - College of Exercise and Health, Shenyang Sport University, Liaoning, China. FAU - Guo, Zeyou AU - Guo Z AD - College of Physical Education and Sports, Beijing Normal University, Beijing, China. FAU - Tang, Wenxuan AU - Tang W AD - College of Exercise and Health, Shenyang Sport University, Liaoning, China. FAU - Sun, Siyao AU - Sun S AD - College of Exercise and Health, Shenyang Sport University, Liaoning, China. FAU - Sun, Mingwei AU - Sun M AD - College of Exercise and Health, Shenyang Sport University, Liaoning, China. FAU - Wang, Yiming AU - Wang Y AD - College of Exercise and Health, Shenyang Sport University, Liaoning, China. FAU - Dou, Guangbo AU - Dou G AD - College of Exercise and Health, Shenyang Sport University, Liaoning, China. douguangbo@lnu.edu.cn. AD - School of Psychology , Bournemouth University, Bournemouth, UK. douguangbo@lnu.edu.cn. LA - eng GR - LJ132410176014/Scientific Research Funding Project of Liaoning Provincial Department of Education-Basic Research Project/ PT - Journal Article DEP - 20260316 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - *Motivation MH - Male MH - Female MH - *Exercise/psychology MH - Young Adult MH - *Body Weight MH - *Body Image/psychology MH - China MH - Adult MH - Adolescent PMC - PMC13107578 OTO - NOTNLM OT - Exercise motivation OT - Latent profile analysis OT - Physical activity OT - Weight and shape concern COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Ethics Committee of Shenyang Sport University (approval number: 202510). Informed consent was obtained from all participants involved in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/17 06:47 MHDA- 2026/06/27 12:38 PMCR- 2026/03/16 CRDT- 2026/03/17 01:04 PHST- 2025/11/27 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/06/27 12:38 [medline] PHST- 2026/03/17 06:47 [pubmed] PHST- 2026/03/17 01:04 [entrez] PHST- 2026/03/16 00:00 [pmc-release] AID - 10.1186/s40359-026-04366-z [pii] AID - 4366 [pii] AID - 10.1186/s40359-026-04366-z [doi] PST - epublish SO - BMC Psychol. 2026 Mar 16;14(1):597. doi: 10.1186/s40359-026-04366-z. PMID- 41840600 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 25 IP - 1 DP - 2026 Mar 17 TI - Validation of the web-based dietary assessment tool (RiksmatenFlex) against doubly labelled water and 24-h dietary recalls in Swedish pre-school children. LID - 10.1186/s12937-026-01315-9 [doi] LID - 40 AB - BACKGROUND: RiksmatenFlex, a Swedish' web-based dietary assessment method, has previously been validated in adolescents and pregnant women. The aim of this study was to evaluate RiksmatenFlex in preschool children by comparing energy intake with total energy expenditure (TEE) measured by the doubly labelled water (DLW) method, by comparing reported intakes of energy, foods, macro- and micronutrients with 24-h dietary recall interviews, and by assessing the parents' perceptions of reporting their child's dietary intake. METHODS: Participants were 94 healthy children, 37 +/- 15 months old, 51% girls, recruited through advertisements (preschools/social media). Energy, selected nutrient and food group intakes were assessed using RiksmatenFlex as a food diary and 24-h dietary recall interviews. TEE (DLW) was measured in a subsample of 37 children. RESULTS: Average energy intake was overestimated by RiksmatenFlex compared to TEE (796 kJ; 21%; P < 0.001) in the subsample. The Bland-Altman plot showed wide limits of agreement (+/- 1797 kJ), and bias towards overreporting at higher intake levels (r = 0.34; P = 0.038). Energy intake and absolute intakes of protein, fat, carbohydrates, calcium (also energy standardised) and fruit-vegetables (combined) were significantly higher with RiksmatenFlex than with the 24-h dietary recalls. Other nutrient and food group intakes were fairly similar with the two methods. Spearman rank correlations ranged from 0.73 (wholegrains) to 0.98 (baby foods). Agreement between the two methods was substantial (K(W)>0.61) for most dietary variables, but not wholegrains, and proportion of energy from macronutrients (K(W) 0.50-0.60). Parents found reporting food intake in RiksmatenFlex easy, with most preferring on-line reporting over interviews. CONCLUSION: The current study showed reasonable validity in young children and the method was well accepted by parents. These finding support its application in large-scale studies of young children, though potential overreporting of energy intake warrants attention. CI - (c) 2026. The Author(s). FAU - Lindroos, Anna Karin AU - Lindroos AK AD - Department of Food Studies, Nutrition and Dietetics, Uppsala university, Box 560, Uppsala, SE-751 22, Sweden. annakarin.lindroos@ikv.uu.se. AD - Department of Risk Benefit Assessment, Swedish Food Agency, Uppsala, Sweden. annakarin.lindroos@ikv.uu.se. FAU - Sipinen, Jessica Petrelius AU - Sipinen JP AD - Department of Risk Benefit Assessment, Swedish Food Agency, Uppsala, Sweden. FAU - Rood, Jennifer AU - Rood J AD - Pennington Biomedical Research Center, Baton Rouge, LA, USA. FAU - Lof, Marie AU - Lof M AD - Department of Medicine Huddinge, Karolinska Institute, Stockholm, Sweden. FAU - Augustin, Hanna AU - Augustin H AD - Department of Internal Medicine and Clinical Nutrition, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Hoppe, Michael AU - Hoppe M AD - Department of Internal Medicine and Clinical Nutrition, the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Moraeus, Lotta AU - Moraeus L AD - Department of Risk Benefit Assessment, Swedish Food Agency, Uppsala, Sweden. LA - eng PT - Journal Article PT - Validation Study DEP - 20260317 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Female MH - Child, Preschool MH - Energy Intake MH - Sweden MH - *Nutrition Assessment MH - Diet Records MH - Mental Recall MH - Male MH - Energy Metabolism MH - *Internet MH - *Diet MH - Reproducibility of Results MH - Micronutrients/administration & dosage MH - *Diet Surveys/methods PMC - PMC13063513 OTO - NOTNLM OT - Diet assessment OT - Energy expenditure OT - Energy intake OT - Food intake OT - Young children COIS- Declarations. Ethics approval and consent to participate: Ethical approval was granted from the Swedish Ethical Review Authority (2020-05293). Written informed consent was collected from both parents before starting the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/17 06:48 MHDA- 2026/04/10 06:32 PMCR- 2026/03/17 CRDT- 2026/03/17 00:59 PHST- 2026/01/06 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/04/10 06:32 [medline] PHST- 2026/03/17 06:48 [pubmed] PHST- 2026/03/17 00:59 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - 10.1186/s12937-026-01315-9 [pii] AID - 1315 [pii] AID - 10.1186/s12937-026-01315-9 [doi] PST - epublish SO - Nutr J. 2026 Mar 17;25(1):40. doi: 10.1186/s12937-026-01315-9. PMID- 41840556 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Mar 16 TI - Comparative reliability and agreement of CBCT-based measurement approaches for assessing maxillary transverse deficiency. LID - 10.1186/s12903-026-08107-x [doi] LID - 648 AB - BACKGROUND: Cone-beam computed tomography (CBCT) enables three-dimensional evaluation of maxillary transverse relationships; however, no consensus exists regarding which CBCT-based diagnostic approach should be used, and the reliability and diagnostic consistency of available systems remain unclear. In this study, the reproducibility and diagnostic agreement of four established CBCT-based transverse assessment methods were compared. METHODS: Ninety-eight patients (mean age: 21.57 years) underwent CBCT. Four diagnostic systems-Penn transverse analysis (PTA), Miner CBCT transverse analysis (CBTA), Yonsei transverse analysis (YTA), and Case Western Reserve University transverse analysis (CWRUTA)-were applied. Two calibrated examiners performed all the measurements twice with a two-week interval. Reliability was assessed using intraclass correlation coefficients (ICCs), Dahlberg's error, and Bland-Altman analyses. Diagnostic agreement was evaluated using Cohen's kappa and cross-method comparisons across skeletal subtypes. RESULTS: All four methods demonstrated acceptable reproducibility (ICC > 0.75), but variation existed across measurements. Compared with inclination-dependent parameters, skeletal width measurements were more repeatable. YTA demonstrated the highest overall reliability and the smallest systematic and random errors, whereas the inclination variables in CWRUTA exhibited the greatest variability and systematic bias. Diagnostic agreement varied across systems and was not interchangeable. YTA and CBTA showed the strongest agreement, whereas CWRUTA classified the greatest proportion of patients as deficient. Agreement increased in skeletal Class III and was lowest in Class II. CONCLUSIONS: CBCT-based transverse diagnostic systems differ in both measurement reproducibility and diagnostic output. YTA demonstrated the most consistent performance and may serve as a reliable primary assessment tool, whereas inclination-based analyses should be interpreted cautiously and in a clinical context. Because no single method fully captures skeletal and dentoalveolar dimensions, a combined diagnostic approach may be more appropriate until standardized criteria and automated CBCT analysis tools become available. FAU - Chen, Sihang AU - Chen S AD - Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology, Fujian Medical University, Jiaotong Road No 88, Fuzhou City, Fujian Province, China. AD - Orthodontics Department, School and Hospital of Stomatology, Fujian Medical University, Yangqiao Zhong Road No 246, Fuzhou City, Fujian Province, China. FAU - Zou, Yuchun AU - Zou Y AD - Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology, Fujian Medical University, Jiaotong Road No 88, Fuzhou City, Fujian Province, China. AD - Orthodontics Department, School and Hospital of Stomatology, Fujian Medical University, Yangqiao Zhong Road No 246, Fuzhou City, Fujian Province, China. FAU - Chen, Zhonghan AU - Chen Z AD - Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology, Fujian Medical University, Jiaotong Road No 88, Fuzhou City, Fujian Province, China. AD - Orthodontics Department, School and Hospital of Stomatology, Fujian Medical University, Yangqiao Zhong Road No 246, Fuzhou City, Fujian Province, China. FAU - Wang, Zhenling AU - Wang Z AD - Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology, Fujian Medical University, Jiaotong Road No 88, Fuzhou City, Fujian Province, China. AD - Orthodontics Department, School and Hospital of Stomatology, Fujian Medical University, Yangqiao Zhong Road No 246, Fuzhou City, Fujian Province, China. FAU - Yu, Qinqi AU - Yu Q AD - Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology, Fujian Medical University, Jiaotong Road No 88, Fuzhou City, Fujian Province, China. AD - Orthodontics Department, School and Hospital of Stomatology, Fujian Medical University, Yangqiao Zhong Road No 246, Fuzhou City, Fujian Province, China. FAU - Cai, Jingwen AU - Cai J AD - Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology, Fujian Medical University, Jiaotong Road No 88, Fuzhou City, Fujian Province, China. AD - Orthodontics Department, School and Hospital of Stomatology, Fujian Medical University, Yangqiao Zhong Road No 246, Fuzhou City, Fujian Province, China. FAU - Chen, Linxin AU - Chen L AD - Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology, Fujian Medical University, Jiaotong Road No 88, Fuzhou City, Fujian Province, China. AD - Orthodontics Department, School and Hospital of Stomatology, Fujian Medical University, Yangqiao Zhong Road No 246, Fuzhou City, Fujian Province, China. FAU - Xu, Linyu AU - Xu L AD - Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology, Fujian Medical University, Jiaotong Road No 88, Fuzhou City, Fujian Province, China. xlyyydentist1042@163.com. AD - Orthodontics Department, School and Hospital of Stomatology, Fujian Medical University, Yangqiao Zhong Road No 246, Fuzhou City, Fujian Province, China. xlyyydentist1042@163.com. FAU - Lin, Hanyu AU - Lin H AD - Fujian Key Laboratory of Oral Diseases, School and Hospital of Stomatology, Fujian Medical University, Jiaotong Road No 88, Fuzhou City, Fujian Province, China. linhyyy@fjmu.edu.cn. LA - eng GR - 2023QH1144/Startup Fund for scientific research, Fujian Medical University/ GR - 2024J01653/Fujian Provincial Natural Science Foundation of China/ PT - Comparative Study PT - Journal Article DEP - 20260316 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Cone-Beam Computed Tomography/methods MH - Reproducibility of Results MH - *Maxilla/diagnostic imaging MH - Female MH - Young Adult MH - Male MH - Cephalometry MH - Adolescent MH - Imaging, Three-Dimensional PMC - PMC13067703 OTO - NOTNLM OT - Cone-beam computed tomography OT - Diagnostic agreement OT - Maxillary transverse discrepancy OT - Reliability OT - Transverse diagnostic methods COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki. This study was approved by the Biomedical Research Ethics Committee of the Affiliated Stomatological Hospital of Fujian Medical University (Approval No. 2024-81). Informed consent was obtained from all participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/17 06:48 MHDA- 2026/06/27 12:37 PMCR- 2026/03/16 CRDT- 2026/03/17 00:57 PHST- 2025/06/27 00:00 [received] PHST- 2026/03/11 00:00 [accepted] PHST- 2026/06/27 12:37 [medline] PHST- 2026/03/17 06:48 [pubmed] PHST- 2026/03/17 00:57 [entrez] PHST- 2026/03/16 00:00 [pmc-release] AID - 10.1186/s12903-026-08107-x [pii] AID - 8107 [pii] AID - 10.1186/s12903-026-08107-x [doi] PST - epublish SO - BMC Oral Health. 2026 Mar 16;26(1):648. doi: 10.1186/s12903-026-08107-x. PMID- 41840063 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260920 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 4 DP - 2026 Mar 16 TI - The breath and mind connection in young people with post-COVID syndrome: feasibility and acceptability of a pilot randomised co-designed intervention. LID - 10.1007/s00431-026-06840-7 [doi] LID - 185 AB - Post-COVID syndrome is widely recognised in children and young people (CYP), where one or more persistent physical symptoms are present 12 weeks after the initial infection that cannot be explained by an alternative cause. We aimed to assess whether an intervention based on narrative therapy and breathing pattern retraining, co-designed with CYP with PCS (12-18 years) was feasible and acceptable within an NHS service. Participants were randomised to standard clinical care or intervention plus standard clinical care. The primary aim was to assess acceptability and feasibility within the study cohort. Intervention effects were evaluated using the Strengths and Difficulties Questionnaire (SDQ) Impact Score,with additional secondary outcomes included the Nijmegen questionnaire, Chandler Fatigue, and EQ-5D-Y, wellness rating, pulmonary function, and exercise testing. Thirty-two CYP were randomised to standard treatment (n = 15) or intervention (n = 17), mean age of 15 years, and 11 (34%) male. Twenty-seven (84%) were diagnosed with breathing pattern disorders. Four intervention groups were offered over 6 months. 14/17 completed the session. Qualitative feedback was positive. There was no statistically significant improvement in the SDQ over time or between groups. Nearly all secondary outcome measures showed statistically significant improvement over time (< 0.001) but not between groups. Conclusions: The intervention was acceptable and feasible to run in an NHS clinic setting for CYP with post-COVID syndrome. Significant improvements seen with time in secondary outcome measures in both groups indicate that post-COVID symptoms improve with time independent of the intervention. What is known - What is new: * Post-COVID syndrome (PCS) affects up to 66.5% of children and young people (CYP) with common persistent or fluctuating symptoms of fatigue, headaches, anxiety, brain fog, breathlessness, and post-exertional malaise and symptom exacerbation. * Few interventions have sought to address both the physical and mental health impact of PCS in adults and the evidence remains limited for CYP. * This novel psychology/physiotherapy co-designed intervention is acceptable and feasible in an NHS clinic setting. * We identified that breathing pattern disorders are common and a predominant cause of breathlessness in teenagers with PCS. CI - (c) 2026. The Author(s). FAU - Wells, Charlotte AU - Wells C AUID- ORCID: 0000-0002-4526-5892 AD - University of Suffolk, Ipswich, UK. c.wells7@uos.ac.uk. AD - Department of Respiratory Paediatrics, The Royal Brompton Hospital part of Guy's and ST Thomas's NHS Foundation Trust, London, UK. c.wells7@uos.ac.uk. FAU - Christie, Deborah AU - Christie D AD - Department of Paediatric and Adolescent Medicine, University College London Hospital NHS Foundation Trust, London, UK. FAU - Johnston, Rebecca AU - Johnston R AD - Guys and St Thomas's NHS Foundation Trust, London, UK. FAU - Knight, Faye AU - Knight F AD - Guys and St Thomas's NHS Foundation Trust, London, UK. FAU - Samuel, Monica AU - Samuel M AD - Department of Paediatric and Adolescent Medicine, University College London Hospital NHS Foundation Trust, London, UK. FAU - Segal, Terry Y AU - Segal TY AD - Department of Paediatric and Adolescent Medicine, University College London Hospital NHS Foundation Trust, London, UK. FAU - Shevlin, Mark AU - Shevlin M AD - Department of Psychology, Ulster University, Coleraine, Northern Ireland. FAU - Sparrow, Rachel AU - Sparrow R AD - Department of Paediatric and Adolescent Medicine, University College London Hospital NHS Foundation Trust, London, UK. FAU - Woodman, Deborah AU - Woodman D AD - Guys and St Thomas's NHS Foundation Trust, London, UK. FAU - Sonnappa, Samatha AU - Sonnappa S AD - Department of Respiratory Paediatrics, The Royal Brompton Hospital part of Guy's and ST Thomas's NHS Foundation Trust, London, UK. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260316 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Breathing Exercises/methods MH - Feasibility Studies MH - Pilot Projects MH - *Post-Acute COVID-19 Syndrome/complications/psychology MH - Surveys and Questionnaires PMC - PMC12992349 OTO - NOTNLM OT - Breathing retraining OT - Narrative therapy OT - Post-COVID syndrome OT - Young people COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted but the Ethics Committee of Yorkshire and the Humber-Leeds East Research Ethics Committee (IRAS number: 315063) in November 2022. Competing interests: The authors declare no competing interests. EDAT- 2026/03/17 06:48 MHDA- 2026/03/17 06:49 PMCR- 2026/03/16 CRDT- 2026/03/17 00:25 PHST- 2025/11/14 00:00 [received] PHST- 2026/03/04 00:00 [accepted] PHST- 2026/02/04 00:00 [revised] PHST- 2026/03/17 06:49 [medline] PHST- 2026/03/17 06:48 [pubmed] PHST- 2026/03/17 00:25 [entrez] PHST- 2026/03/16 00:00 [pmc-release] AID - 10.1007/s00431-026-06840-7 [pii] AID - 6840 [pii] AID - 10.1007/s00431-026-06840-7 [doi] PST - epublish SO - Eur J Pediatr. 2026 Mar 16;185(4):185. doi: 10.1007/s00431-026-06840-7. PMID- 41838777 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 3 DP - 2026 TI - Persistent entropy links irregularities in daily and weekly rest and activity cycles during gestation week 22 and 32 to maternal and neonate health outcomes: A prospective cohort study. PG - e0342509 LID - 10.1371/journal.pone.0342509 [doi] LID - e0342509 AB - Though rest (i.e., sleep and periods of inactivity) and activity levels are known to be altered during pregnancy, the effect of day-to-day consistency in rest-activity cycles on maternal-neonate health is not well characterized. Actigraphy objectively measures rest-activity; however, the large datasets it generates often reveal irregular patterns that are challenging to interpret. We introduce a novel approach that applies persistent homology and entropy, quantitative measures in the field of topological data analysis, to quantify disorder in actigraphic data and examine their association with maternal and neonate health. Actigraphic data were collected from a prospective observational cohort study of pregnant women, with observations at gestational weeks 22 (G22; n = 41) and 32 (G32; n = 44). Persistent entropy was computed for daily and weekly actigraphic data. Participants who experienced maternal or neonate complications, including gestational hypertension, preeclampsia, etc., and adverse birth outcomes had higher average daily entropy at G22 and G32, indicating greater temporal disorder in rest-activity. Furthermore, complicated pregnancies had higher odds of exhibiting high entropy compared to uncomplicated pregnancies OR = 10.38, 95% CI [2.03, 74.68]; Fisher's exact test, p = 0.001), especially in participants with high BMI (OR = 24.00, 95% CI [1.76, 1549.19]; Fisher's exact test, p = 0.005. Receiver operating characteristic (ROC) analysis showed that weekly entropy at G22 had acceptable predictive power (AUC = 0.70; threshold = 8.24; sensitivity = 0.86; specificity = 0.70), whereas entropy at G32 was a weaker predictor. While the analysis yielded a significant association between high entropy at G22 and complicated pregnancies, the wide 95% CI [1.76, 1549.19] suggests that the magnitude of this effect should be interpreted with caution due to the limited sample size. These findings suggest that persistent entropy may be a useful tool for linking rest-activity irregularities to maternal and neonatal health outcomes. Larger studies are needed to evaluate its potential as a predictive model. CI - Copyright: (c) 2026 Vagus et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Vagus, Sashiel AU - Vagus S AUID- ORCID: 0009-0001-6432-1773 AD - Department of Mathematics and Statistics, San Diego State University, San Diego, California, United States of America. FAU - Casey, Theresa M AU - Casey TM AD - Department of Animal Sciences, Purdue University, West Lafayette, Indiana, United States of America. FAU - George, Uduak Z AU - George UZ AUID- ORCID: 0000-0003-2208-3671 AD - Department of Mathematics and Statistics, San Diego State University, San Diego, California, United States of America. LA - eng PT - Journal Article DEP - 20260316 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Prospective Studies MH - Entropy MH - Infant, Newborn MH - Adult MH - *Rest/physiology MH - Pregnancy Outcome MH - Actigraphy MH - Gestational Age MH - Pregnancy Complications PMC - PMC12991255 COIS- The authors have declared that no competing interests exist. EDAT- 2026/03/16 21:57 MHDA- 2026/03/16 21:58 PMCR- 2026/03/16 CRDT- 2026/03/16 13:53 PHST- 2024/11/30 00:00 [received] PHST- 2026/01/24 00:00 [accepted] PHST- 2026/03/16 21:58 [medline] PHST- 2026/03/16 21:57 [pubmed] PHST- 2026/03/16 13:53 [entrez] PHST- 2026/03/16 00:00 [pmc-release] AID - PONE-D-24-48001 [pii] AID - 10.1371/journal.pone.0342509 [doi] PST - epublish SO - PLoS One. 2026 Mar 16;21(3):e0342509. doi: 10.1371/journal.pone.0342509. eCollection 2026. PMID- 41838628 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 3 DP - 2026 TI - Assessing the impact of a tennis-themed sports video game on physical literacy and participation on physical activities among university students: A cluster randomized controlled trial study protocol. PG - e0343594 LID - 10.1371/journal.pone.0343594 [doi] LID - e0343594 AB - INTRODUCTION: Physical literacy (PL) is a multidimensional construct encompassing motivation, confidence, physical competence, knowledge, and understanding, which is essential for fostering lifelong physical activity. University students represent a critical stage for PL development, yet many experience a decline in physical activity and an increase in sedentary behavior after high school. Sports video games (SVGs), though traditionally sedentary, have shown potential to enhance motivation and cognitive engagement with sports. These games are especially popular among university students, making them an accessible and engaging tool for promoting PL. Despite their popularity, the role of SVGs in supporting PL development remains underexplored, particularly in Asian contexts. Integrating technology into physical education, such as through SVGs and virtual simulations, may offer innovative ways to enhance engagement and support PL development. Although the intervention is sedentary, SVG gameplay often requires reflexes and eye-hand coordination which may influence aspects of physical competence such as reaction time and coordination. This study aims to evaluate whether a tennis-themed SVG intervention integrated into PE lessons can enhance students' motivation, sport-specific knowledge, physical competence, social engagement, and physical activity engagement, thereby promoting holistic PL development. METHODS: A cluster randomized controlled trial will be conducted with 176 first-year students enrolled in compulsory tennis physical education courses at The Chinese University of Hong Kong. Eight entire classes (four male and four female) will be randomly assigned to either an intervention or control group. The intervention group will play a tennis SVG, TopSpin 2K25, twice weekly for six weeks alongside regular PE lessons. Assessments at baseline, post-intervention, and three-week follow-up will include self-reported gaming behavior, physical activity level, PL domains, and objective tests of reaction time, eye-hand coordination, and tennis knowledge. DISCUSSION: This protocol examines the integration of SVG into physical education to promote PL across physical, cognitive, affective, and social domains. Limitations include potential contamination bias, variability in prior gaming experience, short intervention duration, and reliance on self-reported measures, which may introduce bias. Theoretically, the study advances PL frameworks by embedding technology-enhanced learning within structured PE contexts. Practically, SVG-based activities offer an inclusive, engaging approach to support diverse learners. Future research should explore long-term effects and develop validated tools for comprehensive assessment. Trial registration: The protocol has been registered on the Open Science Framework on 25 July 2025: https://doi.org/10.17605/OSF.IO/JDYGV. CI - Copyright: (c) 2026 Ho et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Ho, Wai Keung AU - Ho WK AUID- ORCID: 0000-0003-0387-9869 AD - Department of Sports Science and Physical Education, Faculty of Education, The Chinese University of Hong Kong, Hong Kong, China. AD - Physical Education Unit, Faculty of Education, The Chinese University of Hong Kong, Hong Kong, China. FAU - Sum, Raymond Kim Wai AU - Sum RKW AUID- ORCID: 0000-0002-4051-9945 AD - Department of Sports Science and Physical Education, Faculty of Education, The Chinese University of Hong Kong, Hong Kong, China. FAU - Choi, Siu Ming AU - Choi SM AD - Faculty of Education, The University of Macau, Macau, China. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260316 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Video Games MH - *Students/psychology MH - *Tennis MH - Universities MH - *Exercise/psychology MH - Female MH - Randomized Controlled Trials as Topic MH - Motivation MH - Male MH - *Physical Education and Training/methods MH - Adolescent MH - Young Adult PMC - PMC12991259 COIS- The authors have declared that no competing interests exist. EDAT- 2026/03/16 21:57 MHDA- 2026/03/16 21:58 PMCR- 2026/03/16 CRDT- 2026/03/16 13:23 PHST- 2025/09/16 00:00 [received] PHST- 2026/02/07 00:00 [accepted] PHST- 2026/03/16 21:58 [medline] PHST- 2026/03/16 21:57 [pubmed] PHST- 2026/03/16 13:23 [entrez] PHST- 2026/03/16 00:00 [pmc-release] AID - PONE-D-25-48676 [pii] AID - 10.1371/journal.pone.0343594 [doi] PST - epublish SO - PLoS One. 2026 Mar 16;21(3):e0343594. doi: 10.1371/journal.pone.0343594. eCollection 2026. PMID- 41838169 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20261009 IS - 1437-9813 (Electronic) IS - 0179-0358 (Linking) VI - 42 IP - 1 DP - 2026 Mar 16 TI - Flow efficiency of 3D-printed refeeding tubes in a simulated neonatal high-output stoma model. LID - 152 [pii] LID - 10.1007/s00383-026-06395-6 [doi] AB - PURPOSE: Neonatal enterostomies often cause high-output losses of intestinal contents, leading to malabsorption, growth failure, and dependence on parenteral nutrition. Conventional refeeding relies on intermittent or continuous reinfusion and may entail contamination risk and technical difficulties. METHODS: This study introduces an indwelling tube refeeding approach that connects the proximal and distal bowel through a single continuous tube, enabling uninterrupted physiological flow. Using a bench-top in vitro model simulating a neonatal high-output stoma, nine three-dimensional -printed tubes (three diameters x three configurations) were tested at two infusion rates (100 and 50 mL/h). RESULTS: All 90 trials achieved continuous distal outflow without occlusion, confirming technical feasibility. Flow efficiency increased with tube diameter: at 100 mL/h, efficiencies were 95.2 +/- 5.2% (9 mm), 62.5 +/- 12.3% (7 mm), and 55.5 +/- 8.6% (5 mm); a similar pattern was observed at 50 mL/h. Tube configuration and infusion rate had minimal effects on flow efficiency. CONCLUSION: This bench-top study demonstrates the feasibility of an indwelling bridging tube for continuous proximal-to-distal transfer in vitro. Although larger diameters achieved higher flow efficiency, smaller-caliber tubes occupying approximately 40% of the lumen still achieved > 56% efficiency in this model; however, clinical safety and efficacy require further biomechanical and in vivo validation. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Han, Eunseo AU - Han E AD - Department of Medicine, Korea University College of Medicine, Seoul, South Korea. FAU - Kim, Da Eun AU - Kim DE AD - Department of Medicine, Korea University College of Medicine, Seoul, South Korea. FAU - Choi, Won Young AU - Choi WY AD - Department of Medicine, Korea University College of Medicine, Seoul, South Korea. FAU - Go, Dong Gyun AU - Go DG AD - Core Research and Development Center, Korea University Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Ansan, 15355, Gyeonggi-do, South Korea. FAU - Kim, Jae Young AU - Kim JY AD - Core Research and Development Center, Korea University Ansan Hospital, 123, Jeokgeum-ro, Danwon-gu, Ansan, 15355, Gyeonggi-do, South Korea. jaykim830@gmail.com. FAU - Oh, Chaeyoun AU - Oh C AD - Division of Pediatric Surgery, Department of Surgery, Korea University College of Medicine, Korea University Ansan Hospital, 123 Jeokgeum-ro, Danwon-gu, Ansan, South Korea. chaeyoun.o@gmail.com. LA - eng GR - K2516321/Korea University Ansan Hospital/ PT - Journal Article DEP - 20260316 PL - Germany TA - Pediatr Surg Int JT - Pediatric surgery international JID - 8609169 SB - IM MH - *Printing, Three-Dimensional MH - Humans MH - Infant, Newborn MH - Equipment Design MH - *Enteral Nutrition/instrumentation MH - *Enterostomy/instrumentation MH - *Parenteral Nutrition/instrumentation MH - *Surgical Stomas MH - Models, Anatomic OTO - NOTNLM OT - Flow efficiency OT - Indwelling tube refeeding OT - Mucous fistula OT - Neonatal enterostomy OT - Three-dimensional printing (3D printing) COIS- Declarations. Conflict of interest: The authors declare no competing interests. EDAT- 2026/03/16 21:56 MHDA- 2026/03/16 21:57 CRDT- 2026/03/16 12:15 PHST- 2026/03/06 00:00 [received] PHST- 2026/03/08 00:00 [accepted] PHST- 2026/03/16 21:57 [medline] PHST- 2026/03/16 21:56 [pubmed] PHST- 2026/03/16 12:15 [entrez] AID - 10.1007/s00383-026-06395-6 [pii] AID - 10.1007/s00383-026-06395-6 [doi] PST - epublish SO - Pediatr Surg Int. 2026 Mar 16;42(1):152. doi: 10.1007/s00383-026-06395-6. PMID- 41836647 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260316 LR - 20260921 IS - 2398-502X (Print) IS - 2398-502X (Electronic) IS - 2398-502X (Linking) VI - 10 DP - 2025 TI - Untargeted metabolomics data in the By-Band-Sleeve trial and ALSPAC: integrating clinical trial and population cohort data. PG - 632 LID - 10.12688/wellcomeopenres.24917.2 [doi] LID - 632 AB - INTRODUCTION: Metabolomics is the study of measured metabolites and low-molecular weight molecules in a biological specimen, collectively known as the metabolome. Measuring the metabolome in populations is useful for investigating complex, polygenic and multifactorial traits as it can give insight into cellular metabolism and its perturbations in various states of health and disease. Here we present a description of metabolomics data generated using an untargeted mass-spectrometry approach in two studies: (1) the Avon Longitudinal Study of Parents and Children (ALSPAC) - a healthy, general population; and (2) the By-Band-Sleeve trial (BBS) - a pragmatic randomised controlled trial (RCT) of metabolic and bariatric surgery (MBS) plus a non-randomised observational sub-study. METHODS: Samples for this work were collected from ALSPAC participants at 30 years of age. Two sample collection efforts were made within BBS - firstly, from the RCT comparing the effectiveness of three types of MBS: the Roux-en-Y gastric bypass ("bypass"), laparoscopic adjustable gastric band ("band") and the sleeve gastrectomy ("sleeve"), and secondly from the non-randomised (observational) study of MBS. In both instances, samples were collected from patients before and after surgery. In total, 2128 samples were sent for mass-spectrometry (MS) metabolomics analysis by Metabolon (Discovery HD4 platform). Data underwent quality control (QC) via a standard pipeline using the R package metaboprep. RESULTS: After QC, the combined dataset consists of semi-quantitative data for 1176 features in 517 ALSPAC participants and 1062 BBS participants (1018 from the RCT and 44 from the non-randomised study) (1013 pre-surgery samples and 421 post-surgery samples). CONCLUSION: Overall, we have provided a summary of MS data produced across two different study populations, described the QC procedures undertaken and provided some data validation analyses. Bringing together samples from these two studies in a single experiment offers a novel study design able to explore the biological implications of weight and intentional weight loss. CI - Copyright: (c) 2026 Smith M et al. FAU - Smith, Madeleine AU - Smith M AD - Population Health Sciences, University of Bristol, Bristol, England, UK. AD - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England, UK. FAU - Goudswaard, Lucy AU - Goudswaard L AD - Population Health Sciences, University of Bristol, Bristol, England, UK. AD - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England, UK. FAU - Hughes, David AU - Hughes D AD - Population and Public Health Sciences, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA. FAU - Blazeby, Jane AU - Blazeby J AUID- ORCID: 0000-0002-3354-3330 AD - Population Health Sciences and Bristol Biomedical Research Centre, University of Bristol, Bristol, UK. AD - University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, England, UK. FAU - Rogers, Chris AU - Rogers C AUID- ORCID: 0000-0002-9624-2615 AD - Bristol Medical School, University of Bristol, Bristol, UK. FAU - Mazza, Graziella AU - Mazza G AD - Bristol Medical School, University of Bristol, Bristol, UK. FAU - Gidman, Eleanor AU - Gidman E AD - Bristol Medical School, University of Bristol, Bristol, UK. FAU - FitzGibbon, Sophie AU - FitzGibbon S AD - Population Health Sciences, University of Bristol, Bristol, England, UK. FAU - Groom, Alix AU - Groom A AD - Population Health Sciences, University of Bristol, Bristol, England, UK. AD - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England, UK. FAU - Ring, Susan AU - Ring S AUID- ORCID: 0000-0003-3103-9330 AD - Population Health Sciences, University of Bristol, Bristol, England, UK. AD - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England, UK. FAU - Northstone, Kate AU - Northstone K AUID- ORCID: 0000-0002-0602-1983 AD - Population Health Sciences, University of Bristol, Bristol, England, UK. FAU - Matthews, Sarah AU - Matthews S AUID- ORCID: 0009-0001-0525-1744 AD - Population Health Sciences, University of Bristol, Bristol, England, UK. FAU - White, Gail AU - White G AUID- ORCID: 0009-0006-5455-5337 AD - Population Health Sciences, University of Bristol, Bristol, England, UK. FAU - Fabian, Laurie AU - Fabian L AUID- ORCID: 0009-0007-3145-5357 AD - Population Health Sciences, University of Bristol, Bristol, England, UK. FAU - Timpson, Nicholas AU - Timpson N AUID- ORCID: 0000-0002-7141-9189 AD - Population Health Sciences, University of Bristol, Bristol, England, UK. AD - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England, UK. FAU - Corbin, Laura AU - Corbin L AUID- ORCID: 0000-0002-4032-9500 AD - Population Health Sciences, University of Bristol, Bristol, England, UK. AD - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, England, UK. LA - eng GR - WT_/Wellcome Trust/United Kingdom PT - Journal Article DEP - 20260304 PL - England TA - Wellcome Open Res JT - Wellcome open research JID - 101696457 PMC - PMC12982984 OTO - NOTNLM OT - ALSPAC OT - By-Band-Sleeve OT - Metabolon OT - bariatric surgery OT - body mass index OT - mass-spectrometry OT - metabolic surgery OT - metabolomics OT - obesity COIS- No competing interests were disclosed. EDAT- 2026/03/16 21:56 MHDA- 2026/03/16 21:57 PMCR- 2026/03/04 CRDT- 2026/03/16 06:09 PHST- 2026/02/10 00:00 [accepted] PHST- 2026/03/16 21:57 [medline] PHST- 2026/03/16 21:56 [pubmed] PHST- 2026/03/16 06:09 [entrez] PHST- 2026/03/04 00:00 [pmc-release] AID - 10.12688/wellcomeopenres.24917.2 [doi] PST - epublish SO - Wellcome Open Res. 2026 Mar 4;10:632. doi: 10.12688/wellcomeopenres.24917.2. eCollection 2025. PMID- 41835415 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - YouTube videos on nutrition and pediatric cancer: scientific reliability and quality. PG - 1767637 LID - 10.3389/fpubh.2026.1767637 [doi] LID - 1767637 AB - INTRODUCTION: YouTube is widely used as a source of information on health and nutrition. However, concerns exist regarding the reliability and scientific accuracy of its content. This study aims to evaluate the quality, reliability, and scientific accuracy of YouTube videos related to pediatric cancer and nutrition. METHODS: The reliability of the videos was assessed using the mDISCERN scale, their quality was evaluated with the Global Quality Scale (GQS), and their comprehensiveness was measured using the Nutrition and Pediatric Cancer Scoring System (NPCSS), a scale specifically developed for this study. RESULTS: Of the analyzed videos, 60% were classified as useful, while 40% were deemed misleading. Highly reliable videos were found to be longer and more comprehensive; however, their viewership rates were significantly lower (p < 0.05). The majority (66.7%) of the useful videos were presented by dietitians. Correlation analyses demonstrated strong positive relationships between reliability, quality, and comprehensiveness (p < 0.001). Nevertheless, as video quality and reliability increased, viewership rates tended to decrease. The instruments demonstrated an area under the curve ranging between 0.90 and 0.97. DISCUSSION: YouTube contains limited content on pediatric cancer and nutrition, and only slightly more than half of the available videos are classified as useful. Even these useful videos receive low audience engagement, revealing a gap between content quality and viewer reach. This highlights the need to increase high-quality content and enhance the visibility of reliable information. CI - Copyright (c) 2026 Sozlu, Macit-Celebi and Kocaadam-Bozkurt. FAU - Sozlu, Saniye AU - Sozlu S AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Tokat Gaziosmanpasa University, Tokat, Turkiye. FAU - Macit-Celebi, Melahat Sedanur AU - Macit-Celebi MS AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Ondokuz Mayis University, Samsun, Turkiye. FAU - Kocaadam-Bozkurt, Betul AU - Kocaadam-Bozkurt B AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Erzurum Technical University, Erzurum, Turkiye. LA - eng PT - Journal Article DEP - 20260227 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Reproducibility of Results MH - *Neoplasms MH - *Social Media/standards MH - Child MH - *Video Recording/standards MH - *Pediatrics PMC - PMC12982093 OTO - NOTNLM OT - YouTube OT - nutrition OT - pediatric cancer OT - quality OT - reliability COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/16 06:31 MHDA- 2026/03/16 21:58 PMCR- 2026/02/27 CRDT- 2026/03/16 05:59 PHST- 2025/12/14 00:00 [received] PHST- 2026/02/11 00:00 [revised] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/03/16 21:58 [medline] PHST- 2026/03/16 06:31 [pubmed] PHST- 2026/03/16 05:59 [entrez] PHST- 2026/02/27 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1767637 [doi] PST - epublish SO - Front Public Health. 2026 Feb 27;14:1767637. doi: 10.3389/fpubh.2026.1767637. eCollection 2026. PMID- 41834905 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260316 LR - 20260813 IS - 1662-5161 (Print) IS - 1662-5161 (Electronic) IS - 1662-5161 (Linking) VI - 20 DP - 2026 TI - Effects of active action observation on cognitive, emotional, motor, and somatosensory outcomes in adolescents with juvenile idiopathic arthritis: a prospective exploratory case series. PG - 1766070 LID - 10.3389/fnhum.2026.1766070 [doi] LID - 1766070 AB - BACKGROUND: Juvenile Idiopathic Arthritis (JIA) is a heterogeneous pediatric rheumatic disease characterized by persistent pain, functional limitations, and psychosocial difficulties that frequently persist despite optimized pharmacological treatment. Active Action Observation (AAO), which involves observing and then executing goal-directed movements, has been shown to engage mirror-neuron and visuomotor networks. This approach has shown promise in neurological and orthopedic rehabilitation, but has not been studied in adolescents with JIA. OBJECTIVE: To assess the feasibility, acceptability, and preliminary clinical effects of an eight-week home-based AAO telerehabilitation program in adolescents with JIA. METHODS: A prospective exploratory case series included 10 adolescents with JIA (11-17 years). The participants completed an eight-week AAO protocol delivered via weekly pre-recorded YouTube videos and brief online follow-up sessions. Outcomes were assessed at baseline, week 4, and week 8 and included pain interference (PROMIS), stress (SSI-SM), self-efficacy (GSES), fear of pain (FOPQ-III), Timed Up and Go (TUG), hand-grip strength, 6-min walk test (6MWT), and cervical pressure pain thresholds (PPT). The analyses focused on descriptive statistics, change scores, percentage change, and robust estimators (Hodges-Lehmann, Kendall's W). RESULTS: AAO was feasible and well accepted, with no participants withdrawing, and only mild and transient adverse effects reported. From baseline to week 8, the median changes were -42.1% for pain interference, -22.2% for stress, +18.8% for self-efficacy, and -25.7% for fear of pain/movement. While functional mobility (TUG) showed improvement, handgrip strength and 6-min walk test responses were found to be heterogeneous, and cervical PPT exhibited a pattern of increased sensitivity. In line with AAO's neurocognitive framework, the observed reduction in fear of pain, coupled with increased self-efficacy and reduced stress, may indicate an update in threat-related motor representations. This update disrupts the previously formed "movement = danger" association, thereby enabling safer functional engagement and less pain interference. CONCLUSION: AAO delivered at home via telerehabilitation appears to be a feasible, acceptable, and potentially beneficial adjunct for adolescents with JIA, particularly for pain-related and psychological outcomes. These preliminary findings support the feasibility of AAO and justify future controlled trials to establish its efficacy and elucidate the underlying mechanisms. CI - Copyright (c) 2026 Carrasco-Gonzalez, Ceniza-Bordallo, Clemente Garulo, Udaondo Gascon, Lerma-Lara and La Touche. FAU - Carrasco-Gonzalez, Enrique AU - Carrasco-Gonzalez E AD - Physical Therapy Department, CSEU La Salle, Universidad Autonoma de Madrid, Madrid, Spain. AD - Motion in Brains Research Group, CSEU La Salle, Universidad Autonoma de Madrid, Madrid, Spain. AD - Grupo de Investigacion en Neuronciencias Aplicadas a la Rehabilitacion (GINARE), Alcorcon, Spain. FAU - Ceniza-Bordallo, Guillermo AU - Ceniza-Bordallo G AD - Department of Psychiatry, Center for Health Outcomes and Interdisciplinary Research, Massachusetts General Hospital, One Bowdoin Square, Boston, MA, United States. AD - Department of Psychiatry, Harvard Medical School, Boston, MA, United States. FAU - Clemente Garulo, Daniel AU - Clemente Garulo D AD - Unidad de Reumatologia Pediatrica, Hospital Universitario Nino Jesus, Madrid, Spain. FAU - Udaondo Gascon, Clara AU - Udaondo Gascon C AD - Unidad de Reumatologia Pediatrica, Hospital Universitario La Paz, Madrid, Spain. AD - Ciberinfec, Centro de Investigacion Biomedica en Red de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain. FAU - Lerma-Lara, Sergio AU - Lerma-Lara S AD - Physical Therapy Department, CSEU La Salle, Universidad Autonoma de Madrid, Madrid, Spain. AD - Motion in Brains Research Group, CSEU La Salle, Universidad Autonoma de Madrid, Madrid, Spain. FAU - La Touche, Roy AU - La Touche R AD - Physical Therapy Department, CSEU La Salle, Universidad Autonoma de Madrid, Madrid, Spain. AD - Motion in Brains Research Group, CSEU La Salle, Universidad Autonoma de Madrid, Madrid, Spain. LA - eng PT - Journal Article DEP - 20260227 PL - Switzerland TA - Front Hum Neurosci JT - Frontiers in human neuroscience JID - 101477954 PMC - PMC12982409 OTO - NOTNLM OT - exercise OT - juvenile idiopathic arthiritis OT - pain OT - representation techniques OT - telerehbilitation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/16 06:31 MHDA- 2026/03/16 06:32 PMCR- 2026/02/27 CRDT- 2026/03/16 05:54 PHST- 2025/12/11 00:00 [received] PHST- 2026/01/28 00:00 [revised] PHST- 2026/02/03 00:00 [accepted] PHST- 2026/03/16 06:32 [medline] PHST- 2026/03/16 06:31 [pubmed] PHST- 2026/03/16 05:54 [entrez] PHST- 2026/02/27 00:00 [pmc-release] AID - 10.3389/fnhum.2026.1766070 [doi] PST - epublish SO - Front Hum Neurosci. 2026 Feb 27;20:1766070. doi: 10.3389/fnhum.2026.1766070. eCollection 2026. PMID- 41833813 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 2213-3941 (Electronic) IS - 0003-4266 (Linking) VI - 87 IP - 2 DP - 2026 Apr TI - Assessment of hypothalamic syndrome in adult craniopharyngioma patients. PG - 102507 LID - S0003-4266(26)00028-4 [pii] LID - 10.1016/j.ando.2026.102507 [doi] AB - Hypothalamic syndrome (HS) is a rare and severe complication of craniopharyngioma (CP). Diagnostic criteria have been reported for pediatric patients, but no validated criteria exist for adults, limiting clinical recognition and comparability between studies. The present study applied van Santen et al.'s pediatric criteria for HS to an adult cohort with CP, assessing clinical relevance and estimating HS prevalence in this population. We performed a cross-sectional study of adults with histologically confirmed CP followed in a tertiary center. Clinical, biochemical and neuroimaging data were extracted from medical records. Hypothalamic involvement was classified on Muller grade. HS was assessed on van Santen criteria; weight trajectory, hyperphagia, sleep dysregulation, behavioral symptoms, autonomic dysfunction and daytime somnolence. Effect sizes and proportions were calculated accordingly. Twenty-one patients (57.1% female; median age at diagnosis 24.0 years) were included. Most tumors showed limited hypothalamic involvement, with 76.2% Muller grade 0 and no grade 2. Obesity was common (47.6%), but with no hyperphagia. Only 1 patient (4.8%) met the full diagnostic definition of HS. In this adult cohort, characterized by predominantly non-invasive tumors with minimal hypothalamic involvement, prevalence of HS was low on pediatric-derived diagnostic criteria. These findings suggest that van Santen et al.'s criteria have limited sensitivity in adults and that cohort composition, particularly a low rate of hypothalamic invasion, strongly influences HS detection. Larger and more heterogeneous adult cohorts are needed to validate and refine diagnostic criteria for HS in adulthood. CI - Copyright (c) 2026 Elsevier Masson SAS. All rights reserved. FAU - Tavares da Silva, Beatriz AU - Tavares da Silva B AD - Division of Endocrinology, Unidade Local de Saude de Santo Antonio, Centro Hospitalar Universitario de Santo Antonio, Porto, Portugal. Electronic address: u14484@chporto.min-saude.pt. FAU - Neves, Ana Rita AU - Neves AR AD - Instituto de Ciencia Biomedicas Abel Salazar, Universidade do Porto, Porto, Portugal. FAU - Pereira, Maria Teresa AU - Pereira MT AD - Division of Endocrinology, Unidade Local de Saude de Santo Antonio, Centro Hospitalar Universitario de Santo Antonio, Porto, Portugal. FAU - Noronha, Carolina AU - Noronha C AD - Division of Neurosurgery, Unidade Local de Saude de Santo Antonio, Centro Hospitalar Universitario de Santo Antonio, Porto, Portugal. FAU - Ribeiro, Isabel AU - Ribeiro I AD - Division of Neurosurgery, Unidade Local de Saude de Santo Antonio, Centro Hospitalar Universitario de Santo Antonio, Porto, Portugal. FAU - Amaral, Claudia AU - Amaral C AD - Division of Endocrinology, Unidade Local de Saude de Santo Antonio, Centro Hospitalar Universitario de Santo Antonio, Porto, Portugal. LA - eng PT - Journal Article DEP - 20260314 PL - France TA - Ann Endocrinol (Paris) JT - Annales d'endocrinologie JID - 0116744 SB - IM MH - Humans MH - *Craniopharyngioma/complications/epidemiology/pathology/diagnosis MH - Female MH - Adult MH - *Pituitary Neoplasms/complications/epidemiology/pathology MH - *Hypothalamic Diseases/diagnosis/epidemiology/etiology MH - Male MH - Cross-Sectional Studies MH - Young Adult MH - Adolescent MH - Middle Aged MH - Syndrome MH - Prevalence OTO - NOTNLM OT - Adult patients OT - Craniopharyngioma OT - Diagnostic criteria OT - Hypothalamic obesity OT - Hypothalamic syndrome OT - Pituitary dysfunction COIS- Disclosure of interest The authors declare that they have no competing interest. EDAT- 2026/03/16 06:31 MHDA- 2026/05/31 05:33 CRDT- 2026/03/16 00:02 PHST- 2025/06/30 00:00 [received] PHST- 2026/01/31 00:00 [revised] PHST- 2026/02/03 00:00 [accepted] PHST- 2026/05/31 05:33 [medline] PHST- 2026/03/16 06:31 [pubmed] PHST- 2026/03/16 00:02 [entrez] AID - S0003-4266(26)00028-4 [pii] AID - 10.1016/j.ando.2026.102507 [doi] PST - ppublish SO - Ann Endocrinol (Paris). 2026 Apr;87(2):102507. doi: 10.1016/j.ando.2026.102507. Epub 2026 Mar 14. PMID- 41833700 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 1873-6963 (Electronic) IS - 0965-2299 (Linking) VI - 98 DP - 2026 Jun TI - A pilot study of an 8-week, group-based, chakra-informed kundalini yoga intervention for adolescents and young adults with diabetes: Feasibility, youth outcomes, and caregiver distress. PG - 103355 LID - S0965-2299(26)00038-5 [pii] LID - 10.1016/j.ctim.2026.103355 [doi] AB - BACKGROUND: Adolescents and young adults (AYA) with diabetes experience significant biopsychosocial burden linked to hormonal shifts, HPA‑axis dysregulation, autonomic imbalance, metainflammation, and socio‑emotional stress, with heightened challenges among marginalized populations and those with "double diabetes." This pilot evaluated the feasibility of an eight‑week integrative, chakra‑informed yoga program for AYA with type 1 or type 2 diabetes and included caregiver assessments to explore preliminary multidomain outcomes. OBJECTIVE: To assess feasibility and explore preliminary psychological, physiological, relational, and biomarker changes following a developmentally attuned Kundalini yoga program for AYA with diabetes and their caregivers. METHODS: A prospective, single‑arm pilot delivered weekly 90‑minute sessions integrating chakra‑aligned movement, breathwork, mantra, mudras, meditation, journaling, and peer dialogue. Psychological indicators, stress‑regulation markers, relational measures, inflammatory and cardiometabolic biomarkers, glycemic indices, and anthropometrics were collected pre‑intervention, post‑intervention, and three‑month follow‑up. Within‑subject changes were assessed using Wilcoxon signed‑rank tests and Friedman tests. RESULTS: Thirteen AYA (mean age 17.9 +/- 1.8 years; 77% Black/African American; 92% type 1 diabetes) and 12 caregivers completed all assessments. Feasibility was high (attendance 84%; retention 100%). Adolescent diabetes distress decreased pre‑to‑post (p < 0.05); caregiver distress decreased pre‑to‑post and at follow‑up (p < 0.01). Adolescent perceived stress (p = 0.03) and serum cortisol (p = 0.02) declined across timepoints. Total cholesterol (p = 0.01) and LDL (p = 0.01) also decreased. CONCLUSIONS: This single‑group pilot supports feasibility and was associated with improvements in psychological distress, stress‑regulation markers, and cardiometabolic indices. Larger controlled trials are warranted to evaluate potential additive benefits alongside standard diabetes care. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Lekach, Ashley M AU - Lekach AM AD - NewYork-Presbyterian Brooklyn Methodist Hospital, 506 6th Street, Brooklyn, New York,NY 11215, USA. Electronic address: asl9041@nyp.org. FAU - Guss, Debra AU - Guss D AD - NewYork-Presbyterian Brooklyn Methodist Hospital, 506 6th Street, Brooklyn, New York,NY 11215, USA. Electronic address: dag9132@nyp.org. FAU - Chua, Jason AU - Chua J AD - Weill Cornell Medical College, 1300 York Ave., Box 149, New York, NY 10065, USA. Electronic address: jac7024@med.cornell.edu. FAU - Gannon, Ray B AU - Gannon RB AD - NewYork-Presbyterian Hospital, Institute of Nursing Excellence and Innovation, 435 E 70th St, Suite 4K, New York, NY 10021, USA. Electronic address: brg7019@nyp.org. LA - eng PT - Journal Article DEP - 20260313 PL - Scotland TA - Complement Ther Med JT - Complementary therapies in medicine JID - 9308777 SB - IM MH - Humans MH - *Yoga/psychology MH - Pilot Projects MH - Adolescent MH - Male MH - Female MH - Feasibility Studies MH - Young Adult MH - *Stress, Psychological/therapy MH - *Caregivers/psychology MH - Prospective Studies MH - *Diabetes Mellitus, Type 1/therapy/psychology MH - *Diabetes Mellitus, Type 2/therapy/psychology MH - Adult OTO - NOTNLM OT - Adolescent OT - Caregiver distress OT - Diabetes distress OT - Integrative OT - Kundalini yoga OT - Stress physiology COIS- Declaration of Competing Interest The authors declare that they have no known competing financial or non-financial interests or personal relationships that could have appeared to influence the work reported in this manuscript. This includes employment, consultancies, honoraria, patents, or other relationships relevant to the content of the study. Support for this work was provided by the DAISY Foundation Health Equity Grant (Grant No. HEG-2024-1142; Fund No. 653394; ID No. 2174522-1). The funding source had no involvement in the study design, data collection, analysis, interpretation, manuscript preparation, or decision to submit the manuscript for publication. EDAT- 2026/03/16 00:30 MHDA- 2026/04/21 18:33 CRDT- 2026/03/16 00:00 PHST- 2025/12/30 00:00 [received] PHST- 2026/03/06 00:00 [revised] PHST- 2026/03/08 00:00 [accepted] PHST- 2026/04/21 18:33 [medline] PHST- 2026/03/16 00:30 [pubmed] PHST- 2026/03/16 00:00 [entrez] AID - S0965-2299(26)00038-5 [pii] AID - 10.1016/j.ctim.2026.103355 [doi] PST - ppublish SO - Complement Ther Med. 2026 Jun;98:103355. doi: 10.1016/j.ctim.2026.103355. Epub 2026 Mar 13. PMID- 41833363 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1753-4666 (Electronic) IS - 1753-4658 (Print) IS - 1753-4658 (Linking) VI - 20 DP - 2026 Jan-Dec TI - Optimizing clinical strategies for nutritional and immune indices prediction of chronic lung diseases: a cross-sectional study from NHANES 2007-2012. PG - 17534666261432503 LID - 10.1177/17534666261432503 [doi] LID - 17534666261432503 AB - BACKGROUND: Composite nutritional and immune indices (NIIs) have been associated with chronic lung diseases (CLDs). However, systematic research on their associations with different CLD subtypes and potential threshold patterns remains limited. OBJECTIVES: To examine cross-sectional associations between multiple NII and CLD subtypes, and to explore potential linear/nonlinear relationships and threshold ranges using a representative dataset. DESIGN: Cross-sectional, population-based study using National Health and Nutrition Examination Survey (NHANES) data. METHODS: Data were obtained from the US NHANES from 2007 to 2012. Participants aged 18-79 years with complete blood and baseline data were included. Survey-weighted regression models were used to assess associations between NIIs and CLDs. Restricted cubic spline (RCS) regression models were employed to explore linear/nonlinear relationships and potential threshold ranges. RESULTS: The study included 5837 participants (mean age 49.82 +/- 16.15). Regression analyses revealed significant associations between NIIs and CLDs across different ranges. RCS analysis identified thresholds for each NII: prognostic nutritional index (PNI) levels > 46.04 showed a significant inverse association with emphysema and chronic bronchitis. Elevated platelet-to-lymphocyte ratio (PLR) (>113.57) and MLR (>0.14) were positively associated with these conditions. systemic immune-inflammation index (SII) (>429.43) and neutrophil-to-lymphocyte ratio (NLR) (>0.99) were associated with a higher prevalence of asthma, emphysema, and chronic bronchitis. CONCLUSION: In this cross-sectional population-based study, NIIs were associated with different CLD subtypes, with evidence of potential threshold patterns. These findings may help inform future epidemiological studies and hypothesis generation, while causal inference and clinical application require further longitudinal validation. FAU - He, Song AU - He S AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Chen, Cong AU - Chen C AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Hao, Jianqi AU - Hao J AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Shu, Yueli AU - Shu Y AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Yu, Cheng AU - Yu C AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Liu, Xiaojun AU - Liu X AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Wu, Xiaoqing AU - Wu X AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Luo, Nanzhi AU - Luo N AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Zhou, Wenjing AU - Zhou W AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Zha, Zhengyu AU - Zha Z AD - Department of Thoracic Surgery and Institute of Thoracic Oncology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, No.37, Guoxue Valley, Wuhou District, Chengdu, Sichuan 610041, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260315 PL - England TA - Ther Adv Respir Dis JT - Therapeutic advances in respiratory disease JID - 101316317 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Middle Aged MH - Adult MH - Nutrition Surveys MH - Male MH - Aged MH - Adolescent MH - *Nutritional Status MH - United States/epidemiology MH - Young Adult MH - *Lung Diseases/immunology/physiopathology/epidemiology/diagnosis MH - Chronic Disease MH - Predictive Value of Tests MH - *Nutrition Assessment PMC - PMC13009673 OAB - Nutritional and immune indices in chronic lung disease: NHANES 2007-2012Chronic lung diseases (CLDs) like asthma, emphysema, and chronic bronchitis are major health issues. In this study, we explored the association between nutritional and immune indices (NIIs) and CLDs. These indices measure a person's nutrition and immune function. We analyzed data from the National Health and Nutrition Examination Survey (NHANES) between 2007 and 2012, focusing on adults aged 18-79. We examined how different NIIs related to CLDs and identified key threshold values that could predict disease risk. Our results showed that higher levels of prognostic nutritional index (PNI) were linked to a lower risk of emphysema and chronic bronchitis. In contrast, higher levels of platelet-to-lymphocyte ratio (PLR) and MLR were associated with a higher risk of these diseases. Additionally, elevated levels of systemic immune-inflammation index (SII) and neutrophil-to-lymphocyte ratio (NLR) were connected to a greater risk of asthma, emphysema, and chronic bronchitis. More importantly, we clarified specific values and constructed a new predictive framework. This study provides a useful framework for predicting CLD risk based on simple measurements. It can help doctors detect these diseases early and improve prevention and treatment strategies for patients. OABL- eng OTO - NOTNLM OT - National Health and Nutrition Examination Survey OT - asthma OT - chronic obstructive OT - inflammation OT - pulmonary disease COIS- The authors declare that there is no conflict of interest. EDAT- 2026/03/16 00:30 MHDA- 2026/03/16 00:31 PMCR- 2026/03/15 CRDT- 2026/03/15 21:22 PHST- 2026/03/16 00:31 [medline] PHST- 2026/03/16 00:30 [pubmed] PHST- 2026/03/15 21:22 [entrez] PHST- 2026/03/15 00:00 [pmc-release] AID - 10.1177_17534666261432503 [pii] AID - 10.1177/17534666261432503 [doi] PST - ppublish SO - Ther Adv Respir Dis. 2026 Jan-Dec;20:17534666261432503. doi: 10.1177/17534666261432503. Epub 2026 Mar 15. PMID- 41833317 OWN - NLM STAT- Publisher LR - 20260315 IS - 1098-4275 (Electronic) IS - 0031-4005 (Linking) DP - 2026 Mar 16 TI - Clinical Practice Guideline for Diagnosis and Management of Faltering Weight. LID - e2025075764 [pii] LID - 10.1542/peds.2025-075764 [doi] AB - This evidence-based guideline from the American Academy of Pediatrics and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition is intended to support health care providers who care for children with poor weight gain. This clinical practice guideline (CPG) panel updates the term "failure to thrive" to "faltering weight" and using z score cutoffs rather than percentiles as diagnostic criteria. A diagnosis of faltering weight includes any of the following: (1) weight-for-length or body mass index (BMI)-for-age less than -1.65 z score (5th percentile); (2) in children younger than 2 years, weight gain velocity less than -2 z score for age (2.3rd percentile); or (3) decline in weight, weight-for-length, or BMI greater than or equal to 1 z score. This definition was formulated by the guideline panel through an iterative process of discussion and voting to reach consensus. The Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach was used to formulate recommendations and good practice statements, including GRADE Evidence-to-Decision frameworks, which were reviewed by internal and external contributors. The CPG provides 8 Key Action Statements (recommendations) and articulates 4 Good Practice Statements for additional guidance. Diagnostic testing is only recommended for children who have specific conditions that suggest a focal evaluation or persistent faltering weight. In children with persistent faltering weight or who have concerns for conditions that cannot be diagnosed without endoscopy, the CPG suggests endoscopy with biopsy. The CPG recommends the use of increased calories of food/energy; oral nutritional supplementation; and therapy for pediatric feeding disorder. When implemented, the CPG is intended to reduce confusion about diagnostic criteria and improve diagnostic accuracy, decrease overutilization of laboratory testing and imaging in children with faltering weight, and enhance health care utilization. CI - Copyright (c) 2026 by the American Academy of Pediatrics. FAU - Kersten, Hans B AU - Kersten HB AD - St. Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, Pennsylvania. FAU - Goday, Praveen S AU - Goday PS AD - Nutrition and Feeding Programs, Nationwide Children's Hospital, Ohio State University School of Medicine, Columbus, Ohio. FAU - Abdelhadi, Ruba AU - Abdelhadi R AD - University of Missouri-Kansas City School of Medicine, Kansas City, Missouri. FAU - Adolphe, Soukaina AU - Adolphe S AD - Grow Clinic, Boston Medical Center, Chobanian and Avedisian School of Medicine, Boston University, Boston, Massachusetts. FAU - Anania, Nicole AU - Anania N AD - Children's Wisconsin, Milwaukee, Wisconsin. FAU - Bennett, David S AU - Bennett DS AD - St. Christopher's Hospital for Children, Drexel University College of Medicine, Philadelphia, Pennsylvania. FAU - Burke, Leah W AU - Burke LW AD - Department of Pediatrics, Larner College of Medicine, University of Vermont, Burlington, Vermont. FAU - Larson-Nath, Catherine AU - Larson-Nath C AD - Pediatric Gastroenterology, University of Minnesota, Minneapolis, Minnesota. FAU - Lee, Teresa M AU - Lee TM AD - Kentucky Children's Hospital, Lexington, Kentucky. FAU - Leu, Michael G AU - Leu MG AD - Departments of Pediatrics, Biomedical Informatics and Medical Education, and Family Medicine, University of Washington; Information Technology Services, UW Medicine; Seattle Children's Information Technology Department, Seattle Children's Hospital, Seattle, Washington. FAU - Mercer, Shelly AU - Mercer S AD - University of Oklahoma Tulsa School of Community Medicine Tulsa, Oklahoma. FAU - Sentongo, Timothy AU - Sentongo T AD - Section of Pediatric Gastroenterology, Hepatology & Nutrition, University of Chicago, Chicago, Illinois. FAU - Vachani, Joyee Goswami AU - Vachani JG AD - Texas Children's Hospital, Baylor College of Medicine, Houston, Texas. FAU - Senerth, Emily AU - Senerth E AD - Evidence Foundation, Cleveland Heights, Ohio. FAU - Pilcher, Lauren AU - Pilcher L AD - Department of Child Health Finance and Quality, American Academy of Pediatrics, Itasca, Illinois. FAU - Flinn, Susan K AU - Flinn SK AD - Consultant, Alexandria, Virginia. FAU - Okechukwu, Kymika AU - Okechukwu K AD - Department of Child Health Finance and Quality, American Academy of Pediatrics, Itasca, Illinois. FAU - Mustafa, Reem A AU - Mustafa RA AD - Evidence Foundation, Cleveland Heights, Ohio. AD - Division of Nephrology and Hypertension, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas. AD - Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, Canada. FAU - Morgan, Rebecca L AU - Morgan RL AD - Evidence Foundation, Cleveland Heights, Ohio. AD - Division of Nephrology and Hypertension, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas. AD - Department of Population and Quantitative Health Sciences, School of Medicine, Case Western Reserve University, Cleveland, Ohio. CN - AMERICAN ACADEMY OF PEDIATRICS and NORTH AMERICAN SOCIETY FOR PEDIATRIC GASTROENTEROLOGY, HEPATOLOGY AND NUTRITION LA - eng PT - Journal Article DEP - 20260316 PL - United States TA - Pediatrics JT - Pediatrics JID - 0376422 SB - IM EDAT- 2026/03/16 00:30 MHDA- 2026/03/16 00:30 CRDT- 2026/03/15 20:15 PHST- 2026/03/16 00:30 [medline] PHST- 2026/03/16 00:30 [pubmed] PHST- 2026/03/15 20:15 [entrez] AID - 206901 [pii] AID - 10.1542/peds.2025-075764 [doi] PST - aheadofprint SO - Pediatrics. 2026 Mar 16:e2025075764. doi: 10.1542/peds.2025-075764. PMID- 41833281 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 1525-5069 (Electronic) IS - 1525-5050 (Linking) VI - 179 DP - 2026 Jun TI - Eating behavior problems in children with epilepsy (6-16 years): A cross-sectional comparative study. PG - 110987 LID - S1525-5050(26)00108-3 [pii] LID - 10.1016/j.yebeh.2026.110987 [doi] AB - OBJECTIVE: The aim of this study was to evaluate the risk of eating behavior disorders in children and adolescents aged 6-16 years diagnosed with epilepsy, and to compare this risk with that of healthy controls without epilepsy, in order to elucidate the impact of epilepsy on eating behaviors. MATERIALS AND METHODS: The study included 78 patients diagnosed with epilepsy who presented to the Pediatric Neurology Outpatient Clinic of Balikesir University Health Practice and Research Hospital between November 1, 2024 and January 1, 2025, along with 62 age-matched healthy controls without epilepsy and with normal neurological examinations. The diagnosis of epilepsy was established according to the International League Against Epilepsy (ILAE) criteria. Both groups completed the validated Turkish version of the Children's Eating Behaviour Questionnaire (CEBQ). Clinical characteristics of the epilepsy group, including age, sex, seizure type, epilepsy duration, seizure frequency and antiseizure medications (ASMs) use, were also evaluated. RESULTS: No statistically significant differences in eating behavior scores were observed between children with epilepsy and healthy controls (p > 0,05). Furthermore, eating behavior was not significantly associated with epilepsy duration, seizure type or antiseizure medication use. When the epilepsy group was examined within itself, differences in eating behavior were observed between genders. (p < 0,05). CONCLUSION: In this study, eating behaviors assessed by the CEBQ didn't different between children with epilepsy and healthy controls, nor were they associated with epilepsy-related clinical characteristics. However, gender-related changes in eating behavior have been observed in the epilepsy group. Large-scale studies are needed to investigate this situation. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Aycan, Ozlem Kemer AU - Aycan OK AD - Department of Pediatrics, Faculty of Medicine, Balikesir University, Balikesir, Turkiye. Electronic address: ozlem.aycan@balikesir.edu.tr. FAU - Aydin, Hilal AU - Aydin H AD - Department of Pediatric Neurology, Faculty of Medicine, Balikesir University, Balikesir, Turkiye. Electronic address: drhilalaydin@gmail.com. FAU - Tulaci, Ozge Demircan AU - Tulaci OD AD - Department of Child and Adolescent Psychiatry, Balikesir University, Balikesir, Turkiye. Electronic address: ozgedemircantulaci@gmail.com. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260314 PL - United States TA - Epilepsy Behav JT - Epilepsy & behavior : E&B JID - 100892858 SB - IM MH - Humans MH - Child MH - Male MH - Female MH - Adolescent MH - *Epilepsy/complications/psychology/epidemiology MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - *Feeding and Eating Disorders/etiology/epidemiology MH - *Feeding Behavior MH - Turkey OTO - NOTNLM OT - Eating Behavior OT - Epilepsy OT - Pediatric Population COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/16 00:29 MHDA- 2026/04/11 00:32 CRDT- 2026/03/15 19:26 PHST- 2025/09/29 00:00 [received] PHST- 2026/02/28 00:00 [revised] PHST- 2026/03/01 00:00 [accepted] PHST- 2026/04/11 00:32 [medline] PHST- 2026/03/16 00:29 [pubmed] PHST- 2026/03/15 19:26 [entrez] AID - S1525-5050(26)00108-3 [pii] AID - 10.1016/j.yebeh.2026.110987 [doi] PST - ppublish SO - Epilepsy Behav. 2026 Jun;179:110987. doi: 10.1016/j.yebeh.2026.110987. Epub 2026 Mar 14. PMID- 41833066 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1365-2753 (Electronic) IS - 1356-1294 (Print) IS - 1356-1294 (Linking) VI - 32 IP - 2 DP - 2026 Mar TI - Development and Psychometric Testing of the Breastfeeding Knowledge Scale (BKS) in Brazilian Healthcare Students. PG - e70409 LID - 10.1111/jep.70409 [doi] LID - e70409 AB - RATIONALE: Breastfeeding is recognized as a cornerstone of maternal and child health, yet health professionals frequently report insufficient knowledge to provide effective support. Strengthening the evaluation of educational outcomes in health professions training is therefore essential to improve clinical practice and patient care. This study aimed to develop and validate the Breastfeeding Knowledge Scale (BKS), a tool to assess breastfeeding-related knowledge among health professions students in Brazil. METHODS: This study followed COSMIN guidelines. Concept elicitation was conducted through workshops with experts and students to identify relevant domains of breastfeeding knowledge. A pilot study, including cognitive interviews with students, evaluated the comprehensibility and comprehensiveness of items. Content validity was assessed with both students and a multidisciplinary panel of professionals using the content validity index (CVI) and content validity coefficient (CVC), complemented by qualitative feedback. Psychometric testing included exploratory factor analysis (EFA) to evaluate structural validity and guide item reduction, followed by assessment of internal consistency with Cronbach's ⍺, calculated only after confirming the unidimensionality of each subscale. RESULTS: The concept elicitation process yielded five thematic clusters that were reorganized into three broader domains: Biological aspects of lactation, Policy and Sociocultural Context and Clinical Management (including complementary feeding). After iterative refinement and EFA, the instrument was reduced to 40 items. The final version was administered to 143 students. Internal consistency was excellent for the overall scale (Cronbach's ⍺ = 0.910) and strong for each domain (biological = 0.810; policy and sociocultural context = 0.790; clinical management = 0.796). These results supported both structural validity and reliability of the BKS. CONCLUSIONS: The BKS is a valid and reliable instrument for evaluating breastfeeding-related competencies in health professions students. By providing a comprehensive and psychometrically sound measure, it enables rigorous evaluation of training adequacy, supports curriculum improvement and ultimately contributes to strengthening clinical practice and breastfeeding outcomes. CI - (c) 2026 The Author(s). Journal of Evaluation in Clinical Practice published by John Wiley & Sons Ltd. FAU - Peres, Patricia Lima Pereira AU - Peres PLP AUID- ORCID: 0000-0001-7086-8970 AD - Faculdade de Enfermagem, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, Brasil. FAU - Simeon, Rachele AU - Simeon R AUID- ORCID: 0009-0008-0529-354X AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal Child Health (DINOGMI), University of Genoa, Genoa, Italy. FAU - Souza, Maria Helena do Nascimento AU - Souza MHDN AUID- ORCID: 0000-0003-2230-3048 AD - Escola de Enfermagem Anna Nery, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil. FAU - Galeoto, Giovanni AU - Galeoto G AUID- ORCID: 0000-0002-9043-5686 AD - Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy. AD - IRCSS Neuromed, Pozzilli, Isernia, Italy. FAU - Conceicao, Thais Emanuele da AU - Conceicao TED AUID- ORCID: 0000-0002-8730-2559 AD - Escola de Enfermagem Anna Nery, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil. FAU - Berardi, Anna AU - Berardi A AUID- ORCID: 0000-0003-0670-5303 AD - Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy. AD - IRCSS Neuromed, Pozzilli, Isernia, Italy. FAU - Valente, Donatella AU - Valente D AUID- ORCID: 0000-0002-3886-5347 AD - Department of Human Neurosciences, Sapienza University of Rome, Rome, Italy. AD - IRCSS Neuromed, Pozzilli, Isernia, Italy. FAU - Griep, Rosane Harter AU - Griep RH AUID- ORCID: 0000-0002-6250-2036 AD - Instituto Oswaldo Cruz, Fundacao Oswaldo Cruz, Rio de Janeiro, Brasil. LA - eng PT - Journal Article PL - England TA - J Eval Clin Pract JT - Journal of evaluation in clinical practice JID - 9609066 SB - IM MH - Humans MH - *Breast Feeding MH - Psychometrics MH - Brazil MH - Female MH - Reproducibility of Results MH - *Health Knowledge, Attitudes, Practice MH - Pilot Projects MH - *Students, Health Occupations/psychology MH - Surveys and Questionnaires/standards MH - Adult MH - Young Adult MH - Male PMC - PMC12989243 OTO - NOTNLM OT - breastfeeding OT - clinical practice OT - health professions education OT - knowledge OT - psychometrics OT - students OT - validation study COIS- The authors declare no conflicts of interest. EDAT- 2026/03/16 00:30 MHDA- 2026/03/16 00:31 PMCR- 2026/03/15 CRDT- 2026/03/15 18:02 PHST- 2026/02/15 00:00 [revised] PHST- 2025/08/18 00:00 [received] PHST- 2026/03/05 00:00 [accepted] PHST- 2026/03/16 00:31 [medline] PHST- 2026/03/16 00:30 [pubmed] PHST- 2026/03/15 18:02 [entrez] PHST- 2026/03/15 00:00 [pmc-release] AID - JEP70409 [pii] AID - 10.1111/jep.70409 [doi] PST - ppublish SO - J Eval Clin Pract. 2026 Mar;32(2):e70409. doi: 10.1111/jep.70409. PMID- 41832849 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 147 DP - 2026 Jul TI - Defining BMI cutoff points for detecting excess body fat in young adults. PG - 113145 LID - S0899-9007(26)00054-7 [pii] LID - 10.1016/j.nut.2026.113145 [doi] AB - OBJECTIVE: This study aimed to establish new body mass index (BMI) cutoff points for detecting excess body fat in 18-y-old males and females, using air displacement plethysmography (ADP, BodPod(R)) as the reference for measuring percent (%) fat mass. METHODS: A cross-sectional analysis was conducted using data from the 2004 Pelotas Birth Cohort (Brazil), including 3052 individuals at 18 y of age. Body composition was measured using ADP, with excess adiposity defined as body fat percentage >/=20% for males and >/=33% for females. BMI was calculated using the formula, body weight/height(2). Cutoff points were analyzed using the receiver operating characteristic curve (ROC) and the Youden index, comparing sensitivity, specificity, and predictive values of traditional versus proposed cutoff points. RESULTS: The optimal BMI cutoff points for detecting excess body fat were >/=24.0 kg/m(2) for males and >/=23.5 kg/m(2) for females, showing similar accuracy to the traditionally adopted cutoff for overweight (>/=25.0 kg/m(2)) and greater accuracy than the obesity cutoff (>/=30.0 kg/m(2)). The sensitivity of the new cutoff was 2.4 times greater than that of the >/=30.0 kg/m(2) cutoff among males (75.8% vs. 31.9%) and 2.6 times greater among females (82.2% vs. 31.0%). The findings indicate that a BMI >/=30.0 kg/m(2) accurately detects fewer than one-third of young men and women with excess body fat. CONCLUSIONS: The newly proposed BMI cutoff points (>/=24.0 kg/m(2) for males and >/=23.5 kg/m(2) for females) optimize the detection of excess body fat and are more effective than traditional thresholds. These findings may facilitate early detection and support the implementation of public health interventions. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Gonzalez, Maria Cristina AU - Gonzalez MC AD - Postgraduate Program in Nutrition and Food, Federal University of Pelotas, Rio Grande do Sul, Brazil. FAU - Matijasevich, Alicia AU - Matijasevich A AD - Departamento de Medicina Preventiva, Faculdade de Medicina FMUSP, Universidade de Sao Paulo, Sao Paulo, Brazil; Postgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande do Sul, Brazil. FAU - Marques, Gabriela Avila AU - Marques GA AD - Postgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande do Sul, Brazil. Electronic address: gabriamarques@gmail.com. FAU - Rosses, Ana Paula Oliveira AU - Rosses APO AD - Postgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande do Sul, Brazil. FAU - Machado, Ariane Frey AU - Machado AF AD - Postgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande do Sul, Brazil. FAU - Colvara, Camila Correa AU - Colvara CC AD - Postgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande do Sul, Brazil. FAU - Ferro, Debora Vergara AU - Ferro DV AD - Postgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande do Sul, Brazil. FAU - Heller, Glaucia Treichel AU - Heller GT AD - Postgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande do Sul, Brazil. FAU - Brina, Karisa Roxo AU - Brina KR AD - Postgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande do Sul, Brazil. FAU - da Conceicao, Vanessa Barbosa AU - da Conceicao VB AD - Postgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande do Sul, Brazil. FAU - Heymsfield, Steven B AU - Heymsfield SB AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. FAU - Tovo-Rodrigues, Luciana AU - Tovo-Rodrigues L AD - Postgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande do Sul, Brazil. FAU - Santos, Ina S AU - Santos IS AD - Postgraduate Program in Epidemiology, Federal University of Pelotas, Rio Grande do Sul, Brazil. LA - eng PT - Journal Article DEP - 20260211 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Humans MH - Female MH - *Body Mass Index MH - Male MH - Cross-Sectional Studies MH - Adolescent MH - Brazil MH - Body Composition MH - Plethysmography/methods MH - *Adipose Tissue MH - *Adiposity MH - Young Adult MH - *Obesity/diagnosis MH - *Overweight/diagnosis MH - Reference Values MH - Sensitivity and Specificity MH - ROC Curve OTO - NOTNLM OT - Adiposity OT - Body Mass Index OT - Body composition OT - Plethysmography OT - Young adults COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/15 15:08 MHDA- 2026/04/21 17:43 CRDT- 2026/03/15 10:19 PHST- 2025/10/30 00:00 [received] PHST- 2026/01/28 00:00 [revised] PHST- 2026/02/06 00:00 [accepted] PHST- 2026/04/21 17:43 [medline] PHST- 2026/03/15 15:08 [pubmed] PHST- 2026/03/15 10:19 [entrez] AID - S0899-9007(26)00054-7 [pii] AID - 10.1016/j.nut.2026.113145 [doi] PST - ppublish SO - Nutrition. 2026 Jul;147:113145. doi: 10.1016/j.nut.2026.113145. Epub 2026 Feb 11. PMID- 41832847 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 147 DP - 2026 Jul TI - Assessment of a standard dietitian evaluation in pediatric patients with celiac disease. PG - 113169 LID - S0899-9007(26)00077-8 [pii] LID - 10.1016/j.nut.2026.113169 [doi] AB - OBJECTIVE: Evaluate the validity of a standard dietitian evaluation (SDE) assessment of gluten-free dietary (GFD) adherence for pediatric patients with celiac disease (CeD). METHODS: Exploratory and confirmatory factor analyses were conducted in this cross-sectional, retrospective study to evaluate the factor structure of a clinical SDE. Construct validity analyses were performed to establish if the SDE was associated with the primary outcome measure of a biological measure of adherence (autoantibody serology). Retrospective data were gathered from 367 pediatric patients from a large pediatric tertiary care center. Patients identified had a documented diagnosis of CeD and at least one SDE completed by a gastroenterology dietitian between January 2014 and March 2020. RESULTS: The results of the exploratory and confirmatory factor analyses supported a single SDE factor. Greater reduction in autoantibody serology since diagnosis was correlated with better SDE score (partial Spearman rho = 0.22 (95% CI: 0.01, 0.41; P = 0.04). CONCLUSIONS AND PRACTICE IMPLICATIONS: This study is the first to evaluate the structural integrity of an SDE for GFD adherence in pediatric CeD. Findings support the SDE's structural integrity and construct validity with serology, highlighting its potential as a reliable clinical tool for evaluating dietary adherence in pediatric CeD. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Germone, Monique M AU - Germone MM AD - Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA; Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Electronic address: monique.germone@childrenscolorado.org. FAU - Nagle, Sadie S AU - Nagle SS AD - Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA. FAU - Schmiege, Sarah J AU - Schmiege SJ AD - Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Liu, Yuanqing AU - Liu Y AD - Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Stahl, Marisa G AU - Stahl MG AD - Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Shull, Mary H AU - Shull MH AD - Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Pan, Zhaoxing AU - Pan Z AD - Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA; Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Liu, Edwin AU - Liu E AD - Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. FAU - Mehta, Pooja AU - Mehta P AD - Digestive Health Institute, Children's Hospital Colorado, Aurora, Colorado, USA; Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. LA - eng PT - Journal Article DEP - 20260214 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 RN - 0 (Autoantibodies) SB - IM MH - Humans MH - *Celiac Disease/diet therapy MH - *Diet, Gluten-Free/statistics & numerical data MH - Child MH - Female MH - Retrospective Studies MH - Cross-Sectional Studies MH - *Patient Compliance/statistics & numerical data MH - Male MH - *Nutritionists/statistics & numerical data MH - Adolescent MH - Autoantibodies/blood MH - Child, Preschool MH - Reproducibility of Results OTO - NOTNLM OT - Adherence assessment OT - Celiac disease OT - Gluten-free diet OT - Nutrition OT - Pediatric COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships, which may be considered as potential competing interests: Marisa G. Stahl reports a relationship with Takeda Pharmaceutical Company Limited that includes: consulting or advisory. Marisa G. Stahl reports a relationship with Pfizer that includes: consulting or advisory. Marisa G. Stahl reports a relationship with UptoDate Inc that includes: non-financial support. Edwin Liu reports a relationship with Takeda Pharmaceutical Company Limited that includes: consulting or advisory services. Edwin Liu reports a relationship with UptoDate Inc that includes: non-financial support. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/15 15:07 MHDA- 2026/04/21 17:42 CRDT- 2026/03/15 10:19 PHST- 2025/10/17 00:00 [received] PHST- 2026/01/30 00:00 [revised] PHST- 2026/02/10 00:00 [accepted] PHST- 2026/04/21 17:42 [medline] PHST- 2026/03/15 15:07 [pubmed] PHST- 2026/03/15 10:19 [entrez] AID - S0899-9007(26)00077-8 [pii] AID - 10.1016/j.nut.2026.113169 [doi] PST - ppublish SO - Nutrition. 2026 Jul;147:113169. doi: 10.1016/j.nut.2026.113169. Epub 2026 Feb 14. PMID- 41832256 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 14 TI - Standardizing oral microbiome sampling for qPCR: methodological and exploratory insights into nutritional status. LID - 10.1038/s41598-026-43909-7 [doi] LID - 13501 AB - Standardization of oral sample collection methods is essential for accurate and reproducible microbiota quantification. This methodological study aimed to evaluate different oral collection methods to identify the most consistent approach for bacterial quantification by qPCR using samples from adolescent individuals. In addition, to assess the biological applicability of the best method, an exploratory analysis compared bacterial profiles between eutrophic and overweight/obese adolescents and explored associations between bacterial abundance and body composition parameters. Samples of unstimulated saliva, cheek swabs, and biofilm were collected from the same individuals, and qPCR was used to quantify total bacteria (16 S rRNA gene), Bacillota, and Bacteroidota phyla. Unstimulated saliva produced the lowest variability in bacterial quantification compared with other methods (p < 0.05). Moderate correlations were observed between saliva and biofilm, whereas saliva and cheek swab showed weak associations. Although bacterial copy numbers tended to be higher in overweight/obese individuals, these differences were not statistically significant. Correlation matrices suggested group-specific associations between bacterial taxa and body composition parameters, demonstrating the potential of saliva for microbiome assessment in studies of nutritional and metabolic health. This study validated unstimulated saliva as a reproducible, non-invasive, and cost-effective biofluid for oral microbiota quantification by qPCR. The method provides consistent results suitable for large-scale, translational, or point-of-care applications. CI - (c) 2026. The Author(s). FAU - Mendes, Karina AU - Mendes K AD - Center for Interdisciplinary Research in Health (CIIS), Faculty of Dental Medicine (FMD), Universidade Catolica Portuguesa, Estrada da Circunvalacao, 3504-505, Viseu, Portugal. FAU - Gomes, Ana T P C AU - Gomes ATPC AD - Center for Interdisciplinary Research in Health (CIIS), Faculty of Dental Medicine (FMD), Universidade Catolica Portuguesa, Estrada da Circunvalacao, 3504-505, Viseu, Portugal. FAU - Resende, Cristina Maria Mendes AU - Resende CMM AD - Graduate Program in Hebiatria, University of Pernambuco, Recife, Brazil. FAU - Ribeiro, Isabela S AU - Ribeiro IS AD - Graduate Program in Molecular and Cell Biology, University of Pernambuco, Recife, Brazil. FAU - Oliveira, Rafael M C AU - Oliveira RMC AD - Laboratory of Molecular Biology, Hospital Universitario Oswaldo Cruz, University of Pernambuco, Recife, Brazil. FAU - Rosa, Nuno AU - Rosa N AD - Center for Interdisciplinary Research in Health (CIIS), Faculty of Dental Medicine (FMD), Universidade Catolica Portuguesa, Estrada da Circunvalacao, 3504-505, Viseu, Portugal. FAU - Muniz, Maria T C AU - Muniz MTC AD - Graduate Program in Molecular and Cell Biology, University of Pernambuco, Recife, Brazil. FAU - Correia, Maria J AU - Correia MJ AD - Center for Interdisciplinary Research in Health (CIIS), Faculty of Dental Medicine (FMD), Universidade Catolica Portuguesa, Estrada da Circunvalacao, 3504-505, Viseu, Portugal. mcorreia@ucp.pt. LA - eng GR - CEECINST/00070/2021-CIIS-Junior/Fundacao para a Ciencia e a Tecnologia/ GR - UID/04279/2025 and DOI identifier https://doi.org/10.54499/UID/04279/2025 - Centro de Investigacao Interdisciplinar em Saude/Fundacao para a Ciencia e a Tecnologia/ GR - CAPES - Finance code 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ PT - Journal Article DEP - 20260314 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (RNA, Ribosomal, 16S) SB - IM MH - Humans MH - *Microbiota/genetics MH - *Saliva/microbiology MH - Female MH - Adolescent MH - *Mouth/microbiology MH - *Nutritional Status MH - *Real-Time Polymerase Chain Reaction/methods/standards MH - RNA, Ribosomal, 16S/genetics MH - Male MH - Bacteria/genetics/classification MH - *Specimen Handling/methods/standards PMC - PMC13111650 OTO - NOTNLM OT - Bacillota OT - Bacteroidota OT - Oral microbiome OT - QPCR OT - Saliva OT - Sampling methodology COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Ethics Committee of the Instituto de Ciencias Biologicas, Universidade de Pernambuco (Approval number: 4.865.118; CAAE: 42220719.6.0000.5207). The study was conducted in accordance with the Declaration of Helsinki. Written informed consent was obtained from the legal guardians of all participants included in this study. Competing interests: The authors declare no competing interests. EDAT- 2026/03/15 06:48 MHDA- 2026/04/27 00:30 PMCR- 2026/03/14 CRDT- 2026/03/15 00:16 PHST- 2025/12/22 00:00 [received] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/04/27 00:30 [medline] PHST- 2026/03/15 06:48 [pubmed] PHST- 2026/03/15 00:16 [entrez] PHST- 2026/03/14 00:00 [pmc-release] AID - 10.1038/s41598-026-43909-7 [pii] AID - 43909 [pii] AID - 10.1038/s41598-026-43909-7 [doi] PST - epublish SO - Sci Rep. 2026 Mar 14;16(1):13501. doi: 10.1038/s41598-026-43909-7. PMID- 41831651 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1541-6100 (Electronic) IS - 0022-3166 (Print) IS - 0022-3166 (Linking) VI - 156 IP - 5 DP - 2026 May TI - Location-Specific Predictors of Double Burden of Malnutrition among Nigerian Mother-Child Pairs: Re-evaluating Dietary Quality and Socioeconomic Factors. PG - 101478 LID - S0022-3166(26)00127-6 [pii] LID - 10.1016/j.tjnut.2026.101478 [doi] LID - 101478 AB - BACKGROUND: The double burden of malnutrition (DBM), classified as the coexistence of maternal overweight/obesity or maternal undernutrition and child undernutrition or childhood overweight/obesity, within the same household, is an increasing concern in Nigeria. Drivers of DBM may differ by location due to urbanization, socioeconomic gradients, and dietary transitions. OBJECTIVES: This study examined location-specific predictors of DBM among Nigerian mother-child pairs, with a focus on child dietary quality, maternal education, household food insecurity, and wealth index. METHODS: A descriptive cross-sectional study using a stratified multistage sampling technique was conducted among 1295 mother-child pairs (children aged 6-23 mo) across 4 Nigerian cities. Child nutritional status was assessed using World Health Organization (WHO) growth standards, and maternal body mass index was classified according to WHO adult cutoffs. Household food insecurity, dietary diversity, minimum meal frequency, and wealth index were measured using validated tools. Associations between predictors and DBM were examined using chi(2) tests and generalized estimating equations, including interaction and stratified analyses by location. RESULTS: DBM prevalence was 37.4%, with the most frequent phenotype being overweight mothers and undernourished children (34%). Semiurban residence [adjusted odds ratio (AOR): 2.11; 95% confidence interval (CI): 1.93, 2.30], food-secure households (AOR: 1.22; 95% CI: 1.09, 1.37), and not meeting the minimum meal frequency (AOR: 1.41; 95% CI: 1.04, 1.92) were associated with an increased risk of DBM. CONCLUSIONS: DBM among Nigerian mother-child pairs is shaped by dietary factors. Context-specific interventions are needed, with a focus on improving child diet quality in semiurban areas. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Ortutu, Beulah F AU - Ortutu BF AD - Department of Nutrition, Texas A&M University, TX, United States; Department of Human Nutrition and Dietetics, Michael Okpara University of Agriculture, Umudike, Nigeria. Electronic address: beulah@tamu.edu. FAU - Adeleke, Faidat A AU - Adeleke FA AD - Department of Human Nutrition and Dietetics, University of Ibadan, Ibadan, Nigeria. FAU - Idris, Hajara AU - Idris H AD - Department of Pediatrics, Federal Teaching Hospital Katsina, Katsina, Nigeria. FAU - Ezenwa, Chiamaka J AU - Ezenwa CJ AD - Department of Public Health, Federal University of Technology, Owerri, Nigeria. FAU - Adeleke, Folasade A AU - Adeleke FA AD - Department of Nutrition and Dietetics, Modibbo Adama University Teaching Hospital, Yola, Nigeria. FAU - Nwonye, Okemudi AU - Nwonye O AD - Department of Nutrition and Dietetics, Federal University of Agriculture, Mubi, Nigeria. FAU - Edafioghor, Linda O AU - Edafioghor LO AD - Department of Nutrition and Dietetics, Federal University of Medical and Health Science, Kwale, Delta state, Nigeria. FAU - Egechizuorom, Ifeoma M AU - Egechizuorom IM AD - Department of Nutrition and Dietetics, Federal Medical Centre, Umuahia, Nigeria. FAU - Iheme, Gideon O AU - Iheme GO AD - Department of Human Nutrition and Dietetics, Michael Okpara University of Agriculture, Umudike, Nigeria; Department of Food Studies, Nutrition and Dietetics, Uppsala University, Uppsala, Sweden. LA - eng PT - Journal Article DEP - 20260312 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 SB - IM MH - Humans MH - Nigeria/epidemiology MH - Female MH - Cross-Sectional Studies MH - *Socioeconomic Factors MH - *Malnutrition/epidemiology MH - *Diet MH - Infant MH - Mothers MH - Food Insecurity MH - Male MH - Adult MH - Nutritional Status MH - Prevalence PMC - PMC13197940 OTO - NOTNLM OT - Nigeria OT - diet quality OT - double burden of malnutrition (DBM) OT - food insecurity OT - maternal education OT - mother-child pairs OT - wealth index COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/03/15 05:36 MHDA- 2026/05/09 00:34 PMCR- 2026/03/12 CRDT- 2026/03/14 20:13 PHST- 2025/10/14 00:00 [received] PHST- 2025/12/30 00:00 [revised] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/05/09 00:34 [medline] PHST- 2026/03/15 05:36 [pubmed] PHST- 2026/03/14 20:13 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - S0022-3166(26)00127-6 [pii] AID - 101478 [pii] AID - 10.1016/j.tjnut.2026.101478 [doi] PST - ppublish SO - J Nutr. 2026 May;156(5):101478. doi: 10.1016/j.tjnut.2026.101478. Epub 2026 Mar 12. PMID- 41831324 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260917 IS - 1099-1077 (Electronic) IS - 0885-6222 (Print) IS - 0885-6222 (Linking) VI - 41 IP - 2 DP - 2026 Mar TI - Developing a Polygenic Risk Score for Weight Gain in People Treated for Psychosis-Application in a Real-World Setting. PG - e70035 LID - 10.1002/hup.70035 [doi] LID - e70035 AB - INTRODUCTION: Genetic factors are thought to play an important role in antipsychotic-induced weight gain (AIWG). Polygenic risk scores (PRS) could provide a measure of genetic predisposition to antipsychotic drug induced weight gain (AIWG).We conducted a study to examine how a PRS, generated using SNPs, identified from a recent meta-analysis, related to weight-change over time in people with first episode-psychosis. METHODS: The PRS included SNPs in six different genes, identified as having significant associations (p < 0.05) with AIWG. These were HTR2C rs3813929; MTHFR rs1801133; ADRA2A rs1800544; MC4R rs489693; LEPR rs1137101 and CNR1 rs1049353. An additive PRS and a risk allele based weighted PRS were created based on risk allele counts and presence or absence of risk alleles respectively. The additive PRS was also used to create low/high genetic risk groups for analysis. The association between PRS and weight gain per day (WGPD) in grams/day as well as BMI percentage change (=> 7%) was investigated using regression models. RESULTS: In multiple regression analysis, the additive PRS significantly predicted AIWG in females (adjusted r(2) = 0.59, B: unstandardised regression coefficient = 24.4 g/day p < 0.05), but not in males. ANCOVA showed that high genetic risk groups had greater WGPD (p = 0.018), with significant PRS gender interactions driven by markedly higher WGPD in high-risk females (p = 0.039). None of the models tested were associated with BMI percentage change. CONCLUSION: We report a PRS that is predictive of weight gain in women treated for first episode psychosis, accounting for 59% of the variance daily weight-gain over time. Validation in an independent cohort is required, as is determining whether it is feasible to apply the PRS prospectively. CI - (c) 2026 The Author(s). Human Psychopharmacology: Clinical and Experimental published by John Wiley & Sons Ltd. FAU - Heald, Adrian AU - Heald A AUID- ORCID: 0000-0002-9537-4050 AD - Department of Endocrinology and Diabetes, Salford Royal Hospital, Salford, UK. AD - The School of Medicine and Manchester Academic Health Sciences Centre, Manchester University, Manchester, UK. FAU - Illangasekera, Yasitha AU - Illangasekera Y AD - Sheffield Hallam University, Biomolecular Sciences Research Centre, Sheffield, UK. AD - Department of Pharmacology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka. FAU - Loureiro, Camila Marcelino AU - Loureiro CM AD - Sheffield Hallam University, Biomolecular Sciences Research Centre, Sheffield, UK. FAU - Shakespeare, Mark AU - Shakespeare M AD - Rotherham, Doncaster and South Humber NHS Foundation, Doncaster, UK. FAU - Jameson, Adam AU - Jameson A AD - School of Pharmacy and Medical Sciences, University of Bradford, Bradford, UK. AD - Department of Pharmacy, Bradford District Care NHS Foundation Trust, Bradford, UK. FAU - Phillipson, Adrian AU - Phillipson A AD - Rotherham, Doncaster and South Humber NHS Foundation, Doncaster, UK. FAU - Reynolds, Gavin P AU - Reynolds GP AD - Sheffield Hallam University, Biomolecular Sciences Research Centre, Sheffield, UK. AD - Rotherham, Doncaster and South Humber NHS Foundation, Doncaster, UK. FAU - Dalton, Caroline AU - Dalton C AD - Sheffield Hallam University, Biomolecular Sciences Research Centre, Sheffield, UK. LA - eng PT - Journal Article PL - England TA - Hum Psychopharmacol JT - Human psychopharmacology JID - 8702539 RN - 0 (Antipsychotic Agents) RN - 0 (ADRA2A protein, human) RN - EC 1.5.1.20 (MTHFR protein, human) RN - 0 (MC4R protein, human) RN - 0 (LEPR protein, human) RN - 0 (CNR1 protein, human) RN - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2)) RN - 0 (Receptor, Serotonin, 5-HT2C) RN - 0 (Receptor, Melanocortin, Type 4) RN - 0 (Receptors, Adrenergic, alpha-2) RN - 0 (Receptor, Cannabinoid, CB1) RN - 0 (Receptors, Leptin) SB - IM MH - Humans MH - *Weight Gain/drug effects/genetics MH - Female MH - Genetic Risk Score MH - *Antipsychotic Agents/adverse effects/therapeutic use MH - *Psychotic Disorders/drug therapy/genetics MH - Polymorphism, Single Nucleotide MH - Male MH - Adult MH - Genetic Predisposition to Disease MH - Methylenetetrahydrofolate Reductase (NADPH2)/genetics MH - Receptor, Serotonin, 5-HT2C/genetics MH - Young Adult MH - Receptor, Melanocortin, Type 4/genetics MH - *Multifactorial Inheritance MH - Adolescent MH - Receptors, Adrenergic, alpha-2 MH - Receptor, Cannabinoid, CB1 MH - Receptors, Leptin PMC - PMC12988834 OTO - NOTNLM OT - antipsychotic OT - association OT - gene OT - polygenic risk score OT - psychosis OT - weight gain COIS- The authors declare no conflicts of interest. EDAT- 2026/03/15 05:36 MHDA- 2026/03/15 05:37 PMCR- 2026/03/14 CRDT- 2026/03/14 15:43 PHST- 2026/02/05 00:00 [revised] PHST- 2025/11/21 00:00 [received] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/03/15 05:37 [medline] PHST- 2026/03/15 05:36 [pubmed] PHST- 2026/03/14 15:43 [entrez] PHST- 2026/03/14 00:00 [pmc-release] AID - HUP70035 [pii] AID - 10.1002/hup.70035 [doi] PST - ppublish SO - Hum Psychopharmacol. 2026 Mar;41(2):e70035. doi: 10.1002/hup.70035. PMID- 41831190 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Mar 14 TI - Perfectionism, obsessive-compulsive symptoms, and health-thinness-cleanliness motivations as primary correlates of orthorexia nervosa. LID - 10.1007/s40519-026-01823-x [doi] LID - 49 AB - PURPOSE: Orthorexia Nervosa (ON) is characterized by an obsessive preoccupation with eating foods perceived as healthy or clean. Despite growing research interest, risk factors and underlying motivations for ON remain poorly understood. This study examined demographic factors, psychological correlates, and dietary motivations associated with ON symptomatology, building on McComb and Mills' (2019) theoretical model. METHODS: Participants (N = 697) completed validated measures of ON, alongside assessments of demographic factors (age, gender, socioeconomic status, dietary means), psychological variables (perfectionism, obsessive-compulsive symptoms, perceived control, perceived vulnerability to disease, past eating disorder diagnosis), and dietary motivations (thinness, health, cleanliness, muscularity, feeling mentally well). RESULTS: Three dietary motivations: desires to be thin, healthy, and clean were significantly associated with ON symptoms across both measures. Perfectionism (specifically perfectionistic striving) and obsessive-compulsive symptoms (particularly the 'washing' subscale reflecting contamination concerns) emerged as the strongest psychological predictors of ON symptomatology. Demographic variables (age, gender, socioeconomic status) were not associated with ON symptoms, although lower perceived dietary means was associated with higher ON symptomatology. Results were largely replicated using both ON scales. CONCLUSION: ON appears driven by perfectionist striving and contamination-related obsessive-compulsive symptoms, alongside complex motivations that extend beyond health to also include thinness and cleanliness concerns. These findings suggest that ON represents a convergence of multiple motivational domains and highlights potential targets for intervention, including perfectionism-based and exposure-response prevention approaches adapted from obsessive-compulsive disorder and eating disorders treatments. LEVEL OF EVIDENCE: Level V, based on a descriptive study. CI - (c) 2026. The Author(s). FAU - Greville-Harris, Maddy AU - Greville-Harris M AD - Department of Psychology, Washington Singer Laboratories, Health and Life Sciences, University of Exeter, Exeter, EX4 4QG, UK. m.l.greville-harris@exeter.ac.uk. FAU - Vuillier, Laura AU - Vuillier L AD - Department of Psychology Faculty of Science and Technology, Bournemouth University, Poole, BH12 5BB, UK. FAU - Talbot, Catherine AU - Talbot C AD - Department of Psychology Faculty of Science and Technology, Bournemouth University, Poole, BH12 5BB, UK. FAU - Appleton, Katherine AU - Appleton K AD - Department of Psychology Faculty of Science and Technology, Bournemouth University, Poole, BH12 5BB, UK. LA - eng PT - Journal Article DEP - 20260314 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - Female MH - *Perfectionism MH - *Feeding and Eating Disorders/psychology MH - *Motivation/physiology MH - *Obsessive-Compulsive Disorder/psychology MH - Adult MH - Male MH - Young Adult MH - *Thinness/psychology MH - Adolescent MH - *Feeding Behavior/psychology MH - *Obsessive Behavior/psychology PMC - PMC13219126 OTO - NOTNLM OT - Dietary motivations OT - Disordered eating OT - Obsessive-compulsive symptoms OT - Orthorexia nervosa OT - Perfectionism COIS- Declarations. Ethics approval and consent to participate: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Bournemouth University (Ethics number: 39332). Informed consent was obtained from all participants included in the study. Consent for publication: Consent to publish has been received from all participants in this study. Competing interests: The authors declare no competing interests. EDAT- 2026/03/15 05:36 MHDA- 2026/05/29 15:46 PMCR- 2026/03/14 CRDT- 2026/03/14 12:19 PHST- 2025/08/12 00:00 [received] PHST- 2026/02/04 00:00 [accepted] PHST- 2026/05/29 15:46 [medline] PHST- 2026/03/15 05:36 [pubmed] PHST- 2026/03/14 12:19 [entrez] PHST- 2026/03/14 00:00 [pmc-release] AID - 10.1007/s40519-026-01823-x [pii] AID - 1823 [pii] AID - 10.1007/s40519-026-01823-x [doi] PST - epublish SO - Eat Weight Disord. 2026 Mar 14;31(1):49. doi: 10.1007/s40519-026-01823-x. PMID- 41831023 OWN - NLM STAT- MEDLINE DCOM- 20260609 LR - 20261010 IS - 1432-0428 (Electronic) IS - 0012-186X (Linking) VI - 69 IP - 7 DP - 2026 Jul TI - The glycaemic response to morning fasted resistance exercise is more consistent than the response to afternoon fed resistance exercise for adults with type 1 diabetes: a randomised crossover comparison. PG - 1782-1791 LID - 10.1007/s00125-026-06713-6 [doi] AB - AIMS/HYPOTHESIS: People with type 1 diabetes are recommended to modify insulin dosing and/or carbohydrate intake before, during and after exercise to manage blood glucose levels and prevent hypoglycaemia. An exercise strategy that produces a more consistent glycaemic response may facilitate glycaemic management around exercise, thereby reducing barriers to exercise related to blood glucose concentration, such as fear of hypoglycaemia, for people with type 1 diabetes. The aim of this study was to compare the consistency of the glycaemic response to resistance exercise performed in the morning while fasted vs in the afternoon after eating. METHODS: Twelve adults with type 1 diabetes, HbA(1c) <85 mmol/mol (10.0%), aged 18-55 years and without contraindications to resistance exercise completed six identical resistance exercise sessions, three in the morning while fasted (AM-FAST) and three in the afternoon in a fed state (PM-FED). The six sessions were completed in a random order in an unblinded, crossover trial, supervised at the Physical Activity and Diabetes Laboratory at the University of Alberta. We compared the within-participant standard deviation (wpSD) of the capillary blood glucose response to AM-FAST vs PM-FED sessions. Capillary glucose was measured pre-exercise, immediately post exercise and 30 min after exercise. Continuous glucose monitoring data were analysed from immediately post exercise up to 24 h after exercise. RESULTS: The wpSD of the change in capillary glucose during exercise was lower for AM-FAST (1.0+/-1.1 mmol/l) than PM-FED (1.5+/-1.0 mmol/l; p=0.029). There was no difference in the wpSD between conditions during the subsequent 30 min seated recovery (p=0.76). During exercise capillary glucose increased by 1.4+/-1.9 mmol/l for AM-FAST and decreased by 0.9+/-2.3 mmol/l for PM-FED (p=0.017). There was a greater percentage of time in hyperglycaemia in the 6 h post-exercise period following AM-FAST vs PM-FED (56.7% [27.2, 67.9] vs 33.0% [22.6, 41.5]; p=0.003, respectively). CONCLUSIONS/INTERPRETATION: The glycaemic response to AM-FAST was more consistent and characterised by increases in glucose concentration, whereas the glycaemic response to PM-FED was less consistent and produced decreases in glucose concentration. Performing resistance exercise while fasted may reduce barriers to exercise for people with type 1 diabetes due to a more consistent glycaemic response that is less likely to cause hypoglycaemia during exercise. TRIAL REGISTRATION: ClinicalTrials.gov NCT05168488. FUNDING: Dexcom Canada provided in-kind funding in the form of Dexcom G6 transmitters, sensors and receivers. LifeScan Canada provided in-kind funding in capillary glucose testing strips. JEY was supported by a Heart and Stroke Foundation of Canada Alberta New Investigator Award. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - McClure, Reid D AU - McClure RD AUID- ORCID: 0000-0002-9499-6915 AD - Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada. AD - Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada. FAU - Carr, Alice L J AU - Carr ALJ AUID- ORCID: 0000-0003-0704-8843 AD - Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada. FAU - Boule, Normand G AU - Boule NG AUID- ORCID: 0000-0003-0256-702X AD - Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada. AD - Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada. FAU - Yardley, Jane E AU - Yardley JE AUID- ORCID: 0000-0001-8761-7019 AD - Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Edmonton, AB, Canada. Jane.Yardley@ircm.qc.ca. AD - Alberta Diabetes Institute, University of Alberta, Edmonton, AB, Canada. Jane.Yardley@ircm.qc.ca. AD - Institut de Recherches Cliniques de Montreal, Montreal, QC, Canada. Jane.Yardley@ircm.qc.ca. AD - Ecole de kinesiologie et des sciences de l'activite physique, Universite de Montreal, Montreal, QC, Canada. Jane.Yardley@ircm.qc.ca. AD - Augustana Faculty, University of Alberta, Edmonton, AB, Canada. Jane.Yardley@ircm.qc.ca. AD - Women and Children's Health Research Institute, Edmonton, AB, Canada. Jane.Yardley@ircm.qc.ca. LA - eng SI - ClinicalTrials.gov/NCT05168488 GR - In-Kind Funding/Dexcom/ PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20260314 PL - Germany TA - Diabetologia JT - Diabetologia JID - 0006777 RN - 0 (Blood Glucose) RN - 0 (Insulin) RN - 0 (Glycated Hemoglobin) SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/blood/metabolism MH - Adult MH - *Blood Glucose/metabolism MH - Male MH - *Fasting/blood MH - Cross-Over Studies MH - Female MH - Middle Aged MH - Adolescent MH - Young Adult MH - *Exercise/physiology MH - Insulin MH - *Resistance Training MH - Glycated Hemoglobin/metabolism MH - Hypoglycemia/blood OTO - NOTNLM OT - Blood glucose OT - Consistency OT - Fasted exercise OT - Repeatability OT - Type 1 diabetes COIS- Acknowledgements: Thank you to the participants of this study who volunteered their time and lived experience to further the understanding of type 1 diabetes and exercise. Thank you to J. Logan, M. Pringnitz, C. Nitz, K. Goulding and S. Scrase (all University of Alberta) for their help with data collection. Data availability: Data are available from the corresponding author on reasonable request. Funding: Dexcom provided in kind funding in the form of continuous glucose monitoring sensors. LifeScan Canada provided in-kind funding in capillary glucose testing strips. RDM was funded by the Alberta Diabetes Institute's Facilitating Equity in Diabetes Research and Graduate Studentships. Throughout the course of this study JEY was supported by an Alberta New Investigator Award from the Heart and Stroke Foundation of Canada. Authors' relationships and activities: JEY has received speaker's fees from Dexcom. The authors declare that there are no other relationships or activities that might bias, or be perceived to bias, their work. Contribution statement: JEY is the guarantor of the work. RDM collected the data, performed the analyses and wrote the manuscript. ALJC created the code used to analyse CGM data. NGB assisted with statistical analysis. JEY was responsible for the study ideation and design, obtaining ethical approval and oversight of the entire study. All authors assisted in the revision of the manuscript and have approved the final, submitted version. EDAT- 2026/03/15 05:36 MHDA- 2026/06/09 06:34 CRDT- 2026/03/14 12:14 PHST- 2025/10/29 00:00 [received] PHST- 2026/02/03 00:00 [accepted] PHST- 2026/06/09 06:34 [medline] PHST- 2026/03/15 05:36 [pubmed] PHST- 2026/03/14 12:14 [entrez] AID - 10.1007/s00125-026-06713-6 [pii] AID - 10.1007/s00125-026-06713-6 [doi] PST - ppublish SO - Diabetologia. 2026 Jul;69(7):1782-1791. doi: 10.1007/s00125-026-06713-6. Epub 2026 Mar 14. PMID- 41830354 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 0030-9982 (Print) IS - 0030-9982 (Linking) VI - 76 IP - 2 DP - 2026 Feb TI - A ssessm en t of t he re liabilit y of digital cephalom et ric analysis usin g One Ceph app in compa ris on wit h manu al cephalometric an alysis. PG - 187-190 LID - 10.47391/JPMA.21835 [doi] AB - OBJECTIVE: To evaluate and compare the accuracy and reliability of digital cephalometric tracing against the traditional manual tracing method. METHODS: The retrospective, cross-sectional study was conducted at the Department of Orthodontics, Foundation University College of Dentistry and Hospital, Islamabad, Pakistan, from January to April 2024, and comprised randomly-selected, goodquality pre-treatment lateral cephalometric radiographs taken from the same imaging machine. The radiographs were subjected to both manual and digital OneCeph tracing methods by a single operator. Ten cephalometric variables used in Steiner 's analysis were assessed. Data was analysed using SPSS 21. RESULTS: Of the 60 radiographs range assessed, 30(50%) were included; 18(60%) from female patients and 12(40%) from male patients. The patient age was 15-40 years. When subjected to both manual and digital tracing, the radiographs showed no significant difference in any of the 10 parameters assessed between the two methods (p>0.05). CONCLUSIONS: Digital tracing of lateral cephalometric radiographs could be a reliable alternative to manual tracing. FAU - Khan, Mashal AU - Khan M AD - Department of Or thodontics, Foundation University College of Dentistry and Hospital, Foundation University, Islamabad, Pakistan. FAU - Nazir, Rozina AU - Nazir R AD - Department of Or thodontics, Foundation University College of Dentistry and Hospital, Foundation University, Islamabad, Pakistan. FAU - Arshad, Ruhamaa AU - Arshad R AD - Department of Or thodontics, Foundation University College of Dentistry and Hospital, Foundation University, Islamabad, Pakistan. LA - eng PT - Journal Article PL - Pakistan TA - J Pak Med Assoc JT - JPMA. The Journal of the Pakistan Medical Association JID - 7501162 SB - IM MH - Humans MH - *Cephalometry/methods MH - Female MH - Retrospective Studies MH - Cross-Sectional Studies MH - Adolescent MH - Reproducibility of Results MH - Male MH - Adult MH - Young Adult MH - *Mobile Applications OTO - NOTNLM OT - App, Cephalometrics, Analysis, Reliability, Cross-sectional study.. EDAT- 2026/03/14 06:31 MHDA- 2026/03/14 06:32 CRDT- 2026/03/14 05:02 PHST- 2026/03/14 06:32 [medline] PHST- 2026/03/14 06:31 [pubmed] PHST- 2026/03/14 05:02 [entrez] AID - 10.47391/JPMA.21835 [doi] PST - ppublish SO - J Pak Med Assoc. 2026 Feb;76(2):187-190. doi: 10.47391/JPMA.21835. PMID- 41830073 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260719 IS - 1526-4610 (Electronic) IS - 0017-8748 (Linking) VI - 66 IP - 5 DP - 2026 May TI - Differential impact of migraine on severe maternal morbidity and postpartum readmissions: Insights from a national cohort study. PG - 1025-1036 LID - 10.1111/head.70080 [doi] AB - OBJECTIVE: This study evaluates severe maternal morbidity (SMM) and hospital readmissions in women with migraine. BACKGROUND: There has been a rising incidence of SMM and growing urgency to monitor SMM as a measure of maternal outcomes. Migraine is the leading cause of disability in reproductive-aged women and is linked to numerous obstetric comorbidities that likely contribute to SMM, rehospitalization, and resulting healthcare costs. However, population-level data examining these outcomes are limited. METHODS: Using the 2019 National Readmissions Database, we performed a retrospective cohort analysis of index characteristics and postpartum rehospitalizations for women with migraine from January to November 2019. Baseline demographics, hospital characteristics, and indications for readmission were obtained. Odds of SMM at delivery and 30-day nonelective readmission were compared between women with and without migraine. Validated obstetric comorbidity scores and cost of hospitalization were also compared. Models were adjusted for baseline patient and hospital demographics, method of delivery, body mass index (BMI), aspirin use, and obstetric comorbidities. RESULTS: Out of all qualifying deliveries in 2019, 22,074 women had migraine (1.2%). Only 14.2% of these women had a specific migraine diagnosis (n = 3145), of whom 61.7% had migraine with aura (MA; n = 1941) and 38.3% had migraine without aura (MO; n = 1204). Overall, women with migraine had higher obstetric comorbidity scores than those without migraine. Higher odds of SMM were also associated with migraine (odds ratio [OR] 1.82, 95% confidence interval [CI] [1.68, 1.96]). However, after additionally adjusting for comorbidities, this relationship was no longer significant. In contrast, migraine was independently associated with greater odds of 30-day postpartum readmission (migraine: adjusted odds ratio [aOR] 1.29, 95% CI [1.17, 1.41]; MO: aOR 1.49, 95% CI [1.02, 2.10]) and higher hospitalization costs (migraine: adjusted incidence rate ratio [aIRR] 1.18, 95% CI [1.17, 1.19]). CONCLUSION: Women with migraine have higher obstetric comorbidity scores, which may contribute to the elevated risk of SMM. Migraine itself is independently associated with increased 30-day nonelective readmission rates and hospitalization costs. These associations, along with the large number of unspecified migraine diagnoses, highlight the importance of thorough migraine screening and documentation, which may help guide interventions to improve maternal outcomes and reduce healthcare burden. CI - (c) 2026 American Headache Society. FAU - Tram, Michelle T AU - Tram MT AUID- ORCID: 0000-0003-2486-0315 AD - Department of Neurology, Albany Medical Center, Albany, New York, USA. FAU - Cheng, Nan AU - Cheng N AD - Department of Neurology, University of California Irvine, Irvine, California, USA. FAU - Jicha, Crystal AU - Jicha C AUID- ORCID: 0000-0002-0530-2169 AD - Department of Neurology, University of California Irvine, Irvine, California, USA. LA - eng PT - Journal Article DEP - 20260313 PL - United States TA - Headache JT - Headache JID - 2985091R SB - IM MH - Humans MH - Female MH - *Patient Readmission/statistics & numerical data MH - *Migraine Disorders/epidemiology MH - Pregnancy MH - Retrospective Studies MH - Adult MH - Postpartum Period MH - United States/epidemiology MH - Cohort Studies MH - *Pregnancy Complications/epidemiology MH - Comorbidity MH - Young Adult OAB - This study looked at whether migraine is linked to worse health outcomes for mothers after childbirth. Using data from the Nationwide Readmissions Database, we found that women with migraine had a higher risk of delivery complications, 30-day hospital readmission, and cost of stay than those without migraine. These findings suggest that identifying and documenting migraine may be important in guiding better care for new mothers. OABL- eng OTO - NOTNLM OT - aura OT - maternal OT - migraine OT - morbidity OT - postpartum OT - readmission EDAT- 2026/03/14 06:33 MHDA- 2026/05/05 12:39 CRDT- 2026/03/14 01:52 PHST- 2026/01/08 00:00 [revised] PHST- 2025/06/06 00:00 [received] PHST- 2026/01/21 00:00 [accepted] PHST- 2026/05/05 12:39 [medline] PHST- 2026/03/14 06:33 [pubmed] PHST- 2026/03/14 01:52 [entrez] AID - 10.1111/head.70080 [doi] PST - ppublish SO - Headache. 2026 May;66(5):1025-1036. doi: 10.1111/head.70080. Epub 2026 Mar 13. PMID- 41830027 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 5 DP - 2026 Mar 6 TI - Assessment of the Predictive Potential of Pediatric Relative Fat Mass Compared to Alternative Measures of Obesity for Cardiorespiratory Fitness in Children: Longitudinal Associations During Two-Year Follow-Up. LID - 10.3390/nu18050857 [doi] LID - 857 AB - BACKGROUND/OBJECTIVES: Relative Fat Mass (RFM) is an anthropometric index estimating whole-body fat percentage. Though RFM is analyzed in scientific articles in various contexts, the research on the association between RFM and cardiorespiratory fitness (CRF) level is extremely limited. The aim of this study was to investigate the prognostic value of the relative fat mass pediatric index (RFMp) in predicting CRF results over a two-year period among school-age children, in comparison with alternative indices. METHODS: Based on data comprising student measurements collected previously, in the years 2017-2019, a multiple regression analysis was conducted. Predictive models for CRF were constructed over a two-year period, separately for each of the eight indicators associated with obesity assessment. The models were prepared for boys and for girls separately. RESULTS: over 40% of girls and boys have a BMI above the norm. In the case of both girls and boys, RFMp turned out to be the best CRF predictor over a two-year period. It proved to be better in terms of its predictive power than body mass index (BMI), body fat percentage (%BF), waist circumference (WC), waist-to-height ratio (WHtR), waist-to-hip ratio (WHR), tri-ponderal mass index (TMI) and waist-BMI ratio. CONCLUSIONS: RFMp demonstrated a certain advantage in terms of predictive ability compared to alternative indicators. This indicates its potential for implementation in the general pediatric population and clinical practice for the prediction of CRF. However, this needs to be confirmed in further studies involving a larger and more diverse population. FAU - Zadarko-Domaradzka, Maria AU - Zadarko-Domaradzka M AUID- ORCID: 0000-0003-4330-3944 AD - Faculty of Physical Culture Sciences, Medical College, University of Rzeszow, 35-959 Rzeszow, Poland. FAU - Sobolewski, Marek AU - Sobolewski M AUID- ORCID: 0000-0001-6564-8877 AD - Department of Quantitative Methods Rzeszow, University of Technology, 35-959 Rzeszow, Poland. FAU - Zadarko, Emilian AU - Zadarko E AUID- ORCID: 0000-0001-7423-1790 AD - Faculty of Physical Culture Sciences, Medical College, University of Rzeszow, 35-959 Rzeszow, Poland. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260306 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - *Cardiorespiratory Fitness MH - Male MH - Child MH - Body Mass Index MH - Longitudinal Studies MH - *Pediatric Obesity/diagnosis/physiopathology MH - Follow-Up Studies MH - Waist Circumference MH - *Adiposity MH - Predictive Value of Tests MH - Anthropometry/methods MH - *Adipose Tissue PMC - PMC12986975 OTO - NOTNLM OT - CRF OT - RFMp OT - anthropometric measurements OT - health promotion OT - obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/03/14 06:32 MHDA- 2026/03/14 06:33 PMCR- 2026/03/06 CRDT- 2026/03/14 01:11 PHST- 2026/01/23 00:00 [received] PHST- 2026/03/02 00:00 [revised] PHST- 2026/03/04 00:00 [accepted] PHST- 2026/03/14 06:33 [medline] PHST- 2026/03/14 06:32 [pubmed] PHST- 2026/03/14 01:11 [entrez] PHST- 2026/03/06 00:00 [pmc-release] AID - nu18050857 [pii] AID - nutrients-18-00857 [pii] AID - 10.3390/nu18050857 [doi] PST - epublish SO - Nutrients. 2026 Mar 6;18(5):857. doi: 10.3390/nu18050857. PMID- 41829927 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 5 DP - 2026 Feb 26 TI - From Traits to Clusters: Emotional-Sensory-Regulatory Eating Profiles in Generation Z with Implications in Sustainable Food Behavior. LID - 10.3390/nu18050758 [doi] LID - 758 AB - BACKGROUND: Building on our previous systematic review that synthesized eight core sustainable appetitive traits central to food behavior research, the present study extends this framework through an empirical investigation of Generation Z university students in Greece. We have established the conceptual foundation by mapping emotional, sensory, and behavioral regulation drivers of eating behavior, underscoring their relevance for nutrition and sustainability. However, empirical applications of this multidimensional framework to Generation Z remained scarce. OBJECTIVES: This study addresses this gap by examining eating behaviors among approximately 800 students at the University of Ioannina using a validated post-pandemic questionnaire. METHODS & RESULTS: Results revealed heterogeneity across six domains, with consensus observed only in sensory-driven eating (M = 3.88) and openness to new foods (M = 4.00). Cluster analysis identified two distinct profiles: Exploratory and Hedonic Responders and Emotionally Regulated and Satiety-Oriented Responders. These clusters delineate a novel profile of Generation Z, portraying them as digitally immersed, sustainability-oriented, and emotionally sensitive, yet divided between impulsive exploration and regulated satiety. CONCLUSIONS: The study contributes new empirical insights into post-pandemic food behavior. It establishes a comprehensive evidence base for designing culturally sensitive wellness programs and targeted nutritional interventions that support sustainable dietary practices. The continuity between the two papers underscores both theoretical importance and the practical necessity of integrating emotional, sensory, and regulatory dimensions in advancing sustainable eating futures among young adults. FAU - Koliou, Maria P AU - Koliou MP AUID- ORCID: 0009-0009-1751-5629 AD - Laboratory of Food Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. FAU - Kouskoura, Amalia AU - Kouskoura A AD - Management of Technology Research Lab (Materlab), University of Western Macedonia, 50100 Kozani, Greece. FAU - Kontogeorgos, Achilleas AU - Kontogeorgos A AUID- ORCID: 0000-0002-4186-0379 AD - Department of Agriculture, International University of Greece, 57001 Thessaloniki, Greece. FAU - Skalkos, Dimitris AU - Skalkos D AUID- ORCID: 0000-0002-7771-2845 AD - Laboratory of Food Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece. LA - eng PT - Journal Article DEP - 20260226 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Feeding Behavior/psychology MH - Female MH - Male MH - Young Adult MH - Greece MH - *Emotions MH - Surveys and Questionnaires MH - Emotional Eating MH - Cluster Analysis MH - Students/psychology MH - Adult MH - Adolescent PMC - PMC12986968 OTO - NOTNLM OT - Generation Z OT - eating behavior clusters OT - emotional eating sensory cues OT - factorial and cluster analysis OT - public health interventions OT - satiety regulation COIS- The authors declare no conflicts of interest. EDAT- 2026/03/14 06:32 MHDA- 2026/03/14 06:33 PMCR- 2026/02/26 CRDT- 2026/03/14 01:11 PHST- 2026/02/04 00:00 [received] PHST- 2026/02/13 00:00 [revised] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/03/14 06:33 [medline] PHST- 2026/03/14 06:32 [pubmed] PHST- 2026/03/14 01:11 [entrez] PHST- 2026/02/26 00:00 [pmc-release] AID - nu18050758 [pii] AID - nutrients-18-00758 [pii] AID - 10.3390/nu18050758 [doi] PST - epublish SO - Nutrients. 2026 Feb 26;18(5):758. doi: 10.3390/nu18050758. PMID- 41829918 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 5 DP - 2026 Feb 26 TI - Densitometry Versus Bioimpedance for Modeling Vitamin D-Endocrine and Metabolic Associations in Pediatric Obesity: A Cross-Sectional Parallel-Modality Analysis. LID - 10.3390/nu18050750 [doi] LID - 750 AB - Background/Objectives: It has been previously shown that bioimpedance assessment (BIA) systematically underestimates adiposity compared to densitometry analysis (DXA), though the methods correlate strongly. However, whether DXA outperforms BIA for physiology modeling-using vitamin D as a sentinel signal-remains uncertain. We compared DXA and BIA side-by-side to model (i) adiposity-25(OH)D associations, (ii) mediation-style links with metabolic outcomes, and the vitamin D-PTH-calcium axis. Methods: We performed a cross-sectional analysis of 165 children with simple obesity and no vitamin D prophylaxis collected between July 2022 and July 2025. We measured adiposity through DXA and BIA methods, laboratory 25(OH)D, and associated biochemical and clinical parameters: PTH, calcium, phosphate, glucose/insulin/HOMA-IR, lipids. Information on age, sex, and season was recorded and used to adjust for potential covariates. Parallel analyses included partial correlations, linear regression, mediation models, and Bland-Altman analysis for DXA-BIA agreement. Results: The cohort median age was 13 years; median 25(OH)D level was 21.9 ng/mL. DXA fat % exceeded BIA (46.6% vs. 36.7%). Univariately, 25(OH)D correlated inversely with adiposity (DXA rho = -0.16, BIA rho = -0.19), but adiposity was not a significant determinant of 25(OH)D after season/age adjustment with either modality. No mediation of vitamin D to metabolic associations via adiposity were detected. The vitamin D-PTH-calcium axis was robust across modalities. Conclusions: In children with established obesity, seasonal and age factors dominate 25(OH)D variability, while the adiposity contributes little within-group. Vitamin D shows endocrine but not metabolic associations, and within this homogenous pediatric obesity cohort, DXA does not outperform BIA for physiologic modeling. FAU - Jakubowska-Pietkiewicz, Elzbieta AU - Jakubowska-Pietkiewicz E AD - Department of Pediatrics, Newborn Pathology and Bone Metabolic Diseases, University of Lodz, 91-738 Lodz, Poland. FAU - Chrzanowski, Jedrzej AU - Chrzanowski J AUID- ORCID: 0000-0001-6204-8622 AD - Department of Biostatistics and Translational Medicine, Medical University of Lodz, 92-215 Lodz, Poland. FAU - Wozniak, Elzbieta AU - Wozniak E AUID- ORCID: 0000-0002-9629-2452 AD - Department of Pediatrics, Newborn Pathology and Bone Metabolic Diseases, University of Lodz, 91-738 Lodz, Poland. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260226 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 1406-16-2 (Vitamin D) RN - 0 (Parathyroid Hormone) RN - SY7Q814VUP (Calcium) RN - A288AR3C9H (25-hydroxyvitamin D) SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Male MH - *Vitamin D/blood/analogs & derivatives MH - Adolescent MH - Child MH - *Pediatric Obesity/metabolism/blood/physiopathology MH - *Electric Impedance MH - Adiposity MH - *Absorptiometry, Photon/methods MH - Parathyroid Hormone/blood MH - Calcium/blood MH - Body Composition PMC - PMC12986625 OTO - NOTNLM OT - body composition OT - parallel studies OT - pediatric obesity OT - vitamin D COIS- The authors declare no conflicts of interest. EDAT- 2026/03/14 06:31 MHDA- 2026/03/14 06:32 PMCR- 2026/02/26 CRDT- 2026/03/14 01:10 PHST- 2026/01/14 00:00 [received] PHST- 2026/02/18 00:00 [revised] PHST- 2026/02/21 00:00 [accepted] PHST- 2026/03/14 06:32 [medline] PHST- 2026/03/14 06:31 [pubmed] PHST- 2026/03/14 01:10 [entrez] PHST- 2026/02/26 00:00 [pmc-release] AID - nu18050750 [pii] AID - nutrients-18-00750 [pii] AID - 10.3390/nu18050750 [doi] PST - epublish SO - Nutrients. 2026 Feb 26;18(5):750. doi: 10.3390/nu18050750. PMID- 41829905 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 5 DP - 2026 Feb 25 TI - Screening Performance for Insufficient Vegetable Intake in Young Adult Japanese Women: Spot Urinary Potassium Excretion as a Simple, Non-Invasive Marker. LID - 10.3390/nu18050735 [doi] LID - 735 AB - Background/Objectives: Existing methods for assessing the intake of vegetables and fruits have limitations. This study aims to investigate the number of measurements required to screen individuals with insufficient usual vegetable intake or total fruit and vegetable intake using urinary potassium excretion estimated from spot urine samples, a non-invasive and simple biomarker. Methods: A total of 97 women aged 18-24 years provided a 12-day dietary survey, four 24 h urine collections, and three timed spot urine samples per day, collected in a duration of 4 days. Using the dietary surveys as a reference, we evaluated the number of spot urine samples required and their screening performance for identifying individuals whose vegetable intake or total fruit and vegetable intake was below the study population mean. Screening performance was assessed by receiver operating characteristic analysis and the area under the curve (AUC). Results: For vegetable intake, the AUCs were >0.70 when either a single spot urine sample was collected at the second urine void after waking or >/=2 spot urine samples were collected at arbitrary time points. For total fruit and vegetable intake, AUCs were >0.70 when using a single spot urine sample collected at the second void after waking up. Conclusions: These findings suggest that a time-specific single spot urine sample (i.e., the second urine void after waking) or >/=2 spot urine samples collected at arbitrary time points may help in screening individuals with habitually insufficient vegetable intake. FAU - Mizutani, Asaki AU - Mizutani A AD - Department of Food Science and Nutrition, Nara Women's University Graduate School of Humanities and Sciences, Kitauoya-Higashimachi, Nara-shi, Nara 630-8506, Japan. FAU - Yamagishi, Marina AU - Yamagishi M AUID- ORCID: 0009-0003-6030-7928 AD - Department of Food Science and Nutrition, Nara Women's University Graduate School of Humanities and Sciences, Kitauoya-Higashimachi, Nara-shi, Nara 630-8506, Japan. AD - Graduate School of Public Health, International University of Health and Welfare, 4-1-26 Akasaka, Minato-ku, Tokyo 107-8402, Japan. FAU - Sakuda, Mami AU - Sakuda M AUID- ORCID: 0009-0008-6342-2055 AD - Department of Food Science and Nutrition, Nara Women's University Graduate School of Humanities and Sciences, Kitauoya-Higashimachi, Nara-shi, Nara 630-8506, Japan. FAU - Mita, Ayuka AU - Mita A AD - Department of Food Science and Nutrition, Nara Women's University Graduate School of Humanities and Sciences, Kitauoya-Higashimachi, Nara-shi, Nara 630-8506, Japan. FAU - Morita, Emi AU - Morita E AUID- ORCID: 0000-0002-5513-2751 AD - Department of Food Science and Nutrition, Nara Women's University Graduate School of Humanities and Sciences, Kitauoya-Higashimachi, Nara-shi, Nara 630-8506, Japan. FAU - Suga, Naoko AU - Suga N AD - Department of Food Science and Nutrition, Nara Women's University Graduate School of Humanities and Sciences, Kitauoya-Higashimachi, Nara-shi, Nara 630-8506, Japan. FAU - Kitano, Atsuko AU - Kitano A AD - Department of Food Science and Nutrition, Nara Women's University Graduate School of Humanities and Sciences, Kitauoya-Higashimachi, Nara-shi, Nara 630-8506, Japan. FAU - Ohara, Rika AU - Ohara R AD - Department of Food Science and Nutrition, Nara Women's University Graduate School of Humanities and Sciences, Kitauoya-Higashimachi, Nara-shi, Nara 630-8506, Japan. FAU - Takamata, Akira AU - Takamata A AUID- ORCID: 0000-0002-3790-3487 AD - Department of Food Science and Nutrition, Nara Women's University Graduate School of Humanities and Sciences, Kitauoya-Higashimachi, Nara-shi, Nara 630-8506, Japan. FAU - Ishihara, Junko AU - Ishihara J AUID- ORCID: 0000-0002-9516-5646 AD - Graduate School of Environmental Health, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-5201, Japan. FAU - Takachi, Ribeka AU - Takachi R AD - Department of Food Science and Nutrition, Nara Women's University Graduate School of Humanities and Sciences, Kitauoya-Higashimachi, Nara-shi, Nara 630-8506, Japan. LA - eng GR - 23K20170/JSPS KAKENHI/ GR - N/A/Ministry of Agriculture, Forestry and Fisheries (MAFF), Japan/ PT - Journal Article DEP - 20260225 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) RN - RWP5GA015D (Potassium) RN - Japanese people SB - IM MH - Humans MH - Female MH - *Vegetables MH - Adolescent MH - Biomarkers/urine MH - Young Adult MH - *Potassium/urine MH - Japan MH - Fruit MH - *Diet MH - Diet Surveys MH - East Asian People PMC - PMC12986915 OTO - NOTNLM OT - mass screening OT - spot urine OT - urinary potassium OT - vegetables COIS- M.Y. belongs to the Department of Food, Nutritional and Health, Graduate School of Public Health, International University of Health and Welfare which is a social cooperation program with Ajinomoto Co., Inc. and Meiji Co., Ltd. The author declares that Ajinomoto Co., Inc. and Meiji Co., Ltd. had no role in the study design, data collection and analysis, interpretation of data, decision to publish, or preparation of the manuscript. The remaining authors declare that they have no conflicts of interest. EDAT- 2026/03/14 06:32 MHDA- 2026/03/14 06:33 PMCR- 2026/02/25 CRDT- 2026/03/14 01:10 PHST- 2026/01/20 00:00 [received] PHST- 2026/02/13 00:00 [revised] PHST- 2026/02/22 00:00 [accepted] PHST- 2026/03/14 06:33 [medline] PHST- 2026/03/14 06:32 [pubmed] PHST- 2026/03/14 01:10 [entrez] PHST- 2026/02/25 00:00 [pmc-release] AID - nu18050735 [pii] AID - nutrients-18-00735 [pii] AID - 10.3390/nu18050735 [doi] PST - epublish SO - Nutrients. 2026 Feb 25;18(5):735. doi: 10.3390/nu18050735. PMID- 41829653 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 5 DP - 2026 Mar 7 TI - Biomechanical Analysis of the Breaststroke Kick in Young Swimmers Using Wearable Inertial Sensors: An Exploratory Pilot Study. LID - 10.3390/s26051691 [doi] LID - 1691 AB - Breaststroke performance is highly dependent on lower-limb biomechanics and the coordination of movement during the kick cycle. Recent advances in wearable inertial sensor technology enable objective analysis of human motion in real training environments. This study presents an exploratory pilot investigation aimed at evaluating the feasibility of using wearable inertial sensors for biomechanical analysis of the breaststroke kick in young swimmers. Five male children (aged 8-10 years) with basic breaststroke proficiency participated in a single-group pre-post exploratory study conducted over a three-month period. Lower-limb motion was monitored using wearable inertial measurement units attached bilaterally to the shanks and feet, allowing real-time kinematic feedback and data recording during training sessions. The intervention consisted of five structured training sessions integrating drill-based breaststroke kick exercises with sensor-assisted feedback. Outcome measures included time-based swimming performance tests (40 m breaststroke kick with kickboard and 40 m breaststroke without kickboard) and qualitative biomechanical evaluations of the passive and active phases of the breaststroke kick. Additionally, selected IMU-derived kinematic variables (peak ankle dorsiflexion and external foot rotation angles) were analyzed to provide quantitative biomechanical insight. Following the intervention, improvements were observed across all outcome measures, including reduced swimming times and increased technique scores assigned by two independent evaluators. These findings support the feasibility of integrating wearable IMUs for technique monitoring and simple kinematic quantification of breaststroke kick mechanics in young swimmers; larger controlled studies are required to assess efficacy. FAU - Brus, Denisa-Iulia AU - Brus DI AUID- ORCID: 0000-0002-3175-0299 AD - Department of Motor Performance, Transilvania University of Brasov, 500036 Brasov, Romania. FAU - Enoiu, Razvan Sandu AU - Enoiu RS AUID- ORCID: 0000-0001-8488-818X AD - Department of Motor Performance, Transilvania University of Brasov, 500036 Brasov, Romania. FAU - Catana, Dorin-Ioan AU - Catana DI AUID- ORCID: 0000-0001-7554-0720 AD - Department of Materials Engineering and Welding, Transilvania University of Brasov, 500036 Brasov, Romania. LA - eng PT - Journal Article DEP - 20260307 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Swimming/physiology MH - *Wearable Electronic Devices MH - Child MH - Male MH - Biomechanical Phenomena/physiology MH - Pilot Projects MH - Lower Extremity/physiology MH - Athletic Performance/physiology PMC - PMC12987037 OTO - NOTNLM OT - breaststroke kick OT - human motion analysis OT - sensor-based training OT - sports performance OT - swimming biomechanics OT - wearable inertial sensors COIS- The authors declare no conflicts of interest. EDAT- 2026/03/14 06:32 MHDA- 2026/03/14 06:33 PMCR- 2026/03/07 CRDT- 2026/03/14 01:10 PHST- 2026/02/10 00:00 [received] PHST- 2026/03/02 00:00 [revised] PHST- 2026/03/05 00:00 [accepted] PHST- 2026/03/14 06:33 [medline] PHST- 2026/03/14 06:32 [pubmed] PHST- 2026/03/14 01:10 [entrez] PHST- 2026/03/07 00:00 [pmc-release] AID - s26051691 [pii] AID - sensors-26-01691 [pii] AID - 10.3390/s26051691 [doi] PST - epublish SO - Sensors (Basel). 2026 Mar 7;26(5):1691. doi: 10.3390/s26051691. PMID- 41829460 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 5 DP - 2026 Feb 27 TI - Experimental Development of XR Enteral Feeding Function for an Endotracheal Suctioning Training Environment Simulator. LID - 10.3390/s26051499 [doi] LID - 1499 AB - BACKGROUND: Existing XR simulators for enteral feeding rely mainly on self-reported learning outcomes and procedural checklists. As a result, they offer limited opportunities to capture objective behavioral data or to present dynamic patient reactions. This two-stage pilot study evaluated an XR-based gastrostomy tube-feeding simulator (ESTE-TF) that integrates sensor-derived performance metrics and two biological-reaction presentation modalities (projection mapping and tablet display). METHODS: In Experiment 1, nursing students completed pre- and post-experience questionnaires assessing perceived learning across seven domains, alongside sensor-based measurements of feeding-start timing, dosing-rate characteristics, and total procedure time. Experiment 2 employed a tablet-based version with four learning items assessed for students and post-experience evaluations collected from registered nurses. Participants also compared the two XR presentation methods. RESULTS: Students demonstrated perceived learning gains of small-to-large magnitude across both experiments (Experiment 1: d = 0.455-0.974; Experiment 2: d = 0.014-0.886), with wide 95% confidence intervals reflecting the exploratory nature of this pilot work. Sensor-derived data showed greater dosing-rate variability and longer procedure times among students than nurses. Participants reported that projection mapping offered a more embodied experience, whereas tablet displays provided clearer visibility. CONCLUSIONS: These findings indicate the feasibility and preliminary educational potential of integrating sensing technologies with XR-based biological-reaction presentation for gastrostomy-feeding training. Given the small samples and non-validated measures, results should be interpreted as exploratory. Future research will refine sensor accuracy, establish standardized performance metrics, and evaluate learning outcomes using validated instruments and controlled study designs. FAU - Colley, Noriyo AU - Colley N AUID- ORCID: 0000-0002-4811-3499 AD - Faculty of Health Science, Hokkaido University, Hokkaido 060-0808, Japan. FAU - Komizunai, Shunsuke AU - Komizunai S AUID- ORCID: 0000-0002-8406-1737 AD - Faculty of Engineering and Design, Kagawa University, Kagawa 760-0016, Japan. FAU - Sato, Atsuko AU - Sato A AUID- ORCID: 0009-0002-7322-7022 AD - Department of Nursing, Faculty of Nursing, Hiroshima Bunka Gakuen University, Hiroshima 730-0037, Japan. FAU - Ishikawa, Takanori AU - Ishikawa T AUID- ORCID: 0009-0009-6633-6424 AD - Department of Nursing, Faculty of Nursing, Hiroshima Bunka Gakuen University, Hiroshima 730-0037, Japan. FAU - Kouchiyama, Mayumi AU - Kouchiyama M AUID- ORCID: 0009-0007-9751-7864 AD - Department of Nursing, Faculty of Nursing, Hiroshima Bunka Gakuen University, Hiroshima 730-0037, Japan. FAU - Fujimoto, Kazue AU - Fujimoto K AUID- ORCID: 0009-0002-2178-1179 AD - Department of Nursing, Faculty of Nursing, Hiroshima Bunka Gakuen University, Hiroshima 730-0037, Japan. FAU - Nasu, Toshiko AU - Nasu T AD - Department of Nursing, Faculty of Nursing, Hiroshima Bunka Gakuen University, Hiroshima 730-0037, Japan. FAU - Nishima, Ryosuke AU - Nishima R AUID- ORCID: 0009-0004-3193-9667 AD - Department of Nursing, Faculty of Nursing, Hiroshima Bunka Gakuen University, Hiroshima 730-0037, Japan. FAU - Shiota, Aiko AU - Shiota A AUID- ORCID: 0009-0005-2036-5319 AD - Department of Nursing, Faculty of Nursing, Hiroshima Bunka Gakuen University, Hiroshima 730-0037, Japan. FAU - Murata, Eri AU - Murata E AD - Faculty of Medicine and Graduate School of Nursing, Yamagata University, Yamagata 990-0021, Japan. FAU - Matsuda, Yumi AU - Matsuda Y AD - Faculty of Medicine and Graduate School of Nursing, Yamagata University, Yamagata 990-0021, Japan. FAU - Ninomiya, Shinji AU - Ninomiya S AUID- ORCID: 0000-0002-1426-1178 AD - School of Nursing, Faculty of Health Sciences, Hiroshima International University, Hiroshima 739-2631, Japan. LA - eng GR - 22H03701/Japan Society for the Promotion of Science/ PT - Journal Article DEP - 20260227 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Enteral Nutrition/methods MH - Pilot Projects MH - Students, Nursing MH - Learning MH - Male MH - Female MH - Surveys and Questionnaires MH - Gastrostomy MH - Adult PMC - PMC12987111 OTO - NOTNLM OT - XR OT - enteral nutrition OT - nursing education OT - simulation-based training OT - technology-dependent children COIS- The authors declare no conflicts of interest. EDAT- 2026/03/14 06:34 MHDA- 2026/03/14 06:35 PMCR- 2026/02/27 CRDT- 2026/03/14 01:09 PHST- 2025/12/31 00:00 [received] PHST- 2026/02/09 00:00 [revised] PHST- 2026/02/23 00:00 [accepted] PHST- 2026/03/14 06:35 [medline] PHST- 2026/03/14 06:34 [pubmed] PHST- 2026/03/14 01:09 [entrez] PHST- 2026/02/27 00:00 [pmc-release] AID - s26051499 [pii] AID - sensors-26-01499 [pii] AID - 10.3390/s26051499 [doi] PST - epublish SO - Sensors (Basel). 2026 Feb 27;26(5):1499. doi: 10.3390/s26051499. PMID- 41829400 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1424-8220 (Electronic) IS - 1424-8220 (Linking) VI - 26 IP - 5 DP - 2026 Feb 25 TI - Robot-Assisted Gait Training Combined with Conventional Physiotherapy in Postoperative Patients with Diplegic Cerebral Palsy: A Pilot Single Cohort Observational Study. LID - 10.3390/s26051438 [doi] LID - 1438 AB - BACKGROUND: Cerebral palsy (CP) is the most common cause of disability in developmental age, affecting motor and postural skills. With growth, lower-limb orthopedic surgery often becomes necessary. Post-surgical walking rehabilitation programs generally involve conventional therapy with only limited evidence on the use of robot-assisted gait training (RAGT). The aim of the present pilot study is to assess the feasibility and the preliminary functional outcomes of an intensive 3-week rehabilitation of 15 sessions with Lokomat combined with 15 sessions of conventional physiotherapy. METHODS: In total, 27 patients with diplegic cerebral palsy who underwent orthopedic surgery were recruited. Outcomes collected: the 6 min walking test (primary outcome), the Gross Motor Function Measure-88, the Gillette Functional Assessment Questionnaire, 3D gait analysis, and spasticity and force metrics of the lower limbs. Paired statistical tests were used to assess pre-post changes. RESULTS: A pre-post statistically significant improvement was observed in gait endurance in the 6MWT (Delta = 28.56 +/- 34.28 m; p < 0.001) and in gross motor functional skills. Gait parameters showed some functional and structural improvements, and joint stiffness was reduced in some measures. CONCLUSIONS: This combined rehabilitative approach seems to be promising in postoperative patients with CP. Future studies, involving a control group and larger sample size, are needed to generalize our results. FAU - Falivene, Anna AU - Falivene A AUID- ORCID: 0009-0001-2438-5924 AD - Scientific Institute IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy. FAU - Biffi, Emilia AU - Biffi E AUID- ORCID: 0000-0002-2568-9735 AD - Scientific Institute IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy. FAU - Molteni, Luca Emanuele AU - Molteni LE AUID- ORCID: 0009-0009-5193-2899 AD - Scientific Institute IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy. FAU - Maghini, Cristina AU - Maghini C AD - Scientific Institute IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy. FAU - Cima, Rossella AU - Cima R AUID- ORCID: 0000-0003-2575-3829 AD - Scientific Institute IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy. FAU - Morganti, Roberta AU - Morganti R AD - Scientific Institute IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy. FAU - Diella, Eleonora AU - Diella E AUID- ORCID: 0000-0003-2756-9355 AD - Scientific Institute IRCCS Eugenio Medea, 23842 Bosisio Parini, Italy. LA - eng GR - #PNC0000007/Italian Ministry of University and Research, under the complementary actions to the NRRP "Fit4MedRob- Fit for Medical Robotics"/ GR - Ricerca Corrente 2025/2026 to E. B./This research was funded by the Italian Ministry of Health/ PT - Journal Article PT - Observational Study DEP - 20260225 PL - Switzerland TA - Sensors (Basel) JT - Sensors (Basel, Switzerland) JID - 101204366 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology/rehabilitation/surgery/therapy MH - *Robotics/methods MH - Female MH - *Gait/physiology MH - Pilot Projects MH - Male MH - *Physical Therapy Modalities MH - Child MH - Adolescent MH - Walking/physiology MH - Adult PMC - PMC12987000 OTO - NOTNLM OT - cerebral palsy OT - neurorehabilitation OT - postoperative patients OT - robotic training COIS- The authors declare no conflicts of interest. EDAT- 2026/03/14 06:33 MHDA- 2026/03/14 06:34 PMCR- 2026/02/25 CRDT- 2026/03/14 01:09 PHST- 2025/11/25 00:00 [received] PHST- 2026/02/11 00:00 [revised] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/03/14 06:34 [medline] PHST- 2026/03/14 06:33 [pubmed] PHST- 2026/03/14 01:09 [entrez] PHST- 2026/02/25 00:00 [pmc-release] AID - s26051438 [pii] AID - sensors-26-01438 [pii] AID - 10.3390/s26051438 [doi] PST - epublish SO - Sensors (Basel). 2026 Feb 25;26(5):1438. doi: 10.3390/s26051438. PMID- 41827687 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260314 LR - 20260813 IS - 2072-6694 (Print) IS - 2072-6694 (Electronic) IS - 2072-6694 (Linking) VI - 18 IP - 5 DP - 2026 Feb 26 TI - Structured and Unstructured Physical Activity, Screen Time and Quality of Life in Childhood Cancer Survivors. LID - 10.3390/cancers18050752 [doi] LID - 752 AB - Background/Objectives: Childhood cancer survivors face long-term cancer-related health risks, and daily behaviours, such as physical activity and recreational screen use, may influence their long-term overall wellbeing. Yet, little is known about survivors' knowledge and understanding of recommended guidelines or their patterns of structured and unstructured activity. This study aimed to (i) assess survivors' knowledge of physical activity and screen time guidelines, (ii) describe their self-reported (un)structured activity and screen use across weekdays and weekends, and (iii) examine associations with health-related quality of life. Methods: This secondary analysis used data from a feasibility pilot study of an intervention for survivors aged 8-13 years who had completed cancer treatment at least 12 months earlier. Participants self-reported physical activity, recreational screen use, knowledge of guidelines, and health-related quality of life (HRQoL). We used descriptive statistics and non-parametric tests to analyse behavioural patterns and associations. Results: Over one-third of survivors underestimated or overestimated the recommended physical activity and screen time (35%), whilst 23-50% reported 'don't know'. Participation in 'Physical Education' classes at school did not differ between summer and winter school terms, yet there was greater participation in structured physical activities in winter compared to summer school terms (median 270 vs. 170 min/week). For unstructured physical activities, 69% reported engaging in a median of 60 min/week at school on most days of the week in summer, whilst most survivors (96%) did not report any unstructured activity in winter. Only 19% met the recommended daily minimum of 60 min of physical activity year-round. Excessive screen use increased from school days (19%) to weekends (46%), notably handheld device screen time. We did not find any significant associations between meeting physical activity and screen time recommendations and HRQoL. Conclusions: Survivors frequently engage in irregular structured and unstructured physical activity levels and increased screen time. These findings emphasise the need for targeted, year-round interventions to improve physical activity, reduce recreational screen use, and support long-term survivorship health. FAU - Ha, Lauren AU - Ha L AUID- ORCID: 0000-0001-6494-5861 AD - Behavioural Sciences Unit, Discipline of Paediatrics & Child Health, School of Clinical Medicine, Randwick Clinical Campus, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW 2052, Australia. AD - Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW 2031, Australia. FAU - Singleton, Darcy AU - Singleton D AD - Behavioural Sciences Unit, Discipline of Paediatrics & Child Health, School of Clinical Medicine, Randwick Clinical Campus, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW 2052, Australia. AD - Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW 2031, Australia. FAU - Wakefield, Claire E AU - Wakefield CE AUID- ORCID: 0000-0001-7704-7067 AD - Behavioural Sciences Unit, Discipline of Paediatrics & Child Health, School of Clinical Medicine, Randwick Clinical Campus, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW 2052, Australia. AD - Division of Quality of Life and Pediatric Palliative Care, Stanford University, Stanford, CA 94305, USA. FAU - Cohn, Richard J AU - Cohn RJ AUID- ORCID: 0000-0002-2400-1353 AD - Behavioural Sciences Unit, Discipline of Paediatrics & Child Health, School of Clinical Medicine, Randwick Clinical Campus, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW 2052, Australia. AD - Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW 2031, Australia. FAU - Simar, David AU - Simar D AUID- ORCID: 0000-0002-3862-1932 AD - Faculty of Medicine & Health, UNSW Sydney, Sydney, NSW 2052, Australia. FAU - Signorelli, Christina AU - Signorelli C AUID- ORCID: 0000-0002-7091-0347 AD - Behavioural Sciences Unit, Discipline of Paediatrics & Child Health, School of Clinical Medicine, Randwick Clinical Campus, UNSW Medicine & Health, UNSW Sydney, Sydney, NSW 2052, Australia. AD - Kids Cancer Centre, Sydney Children's Hospital, Randwick, NSW 2031, Australia. LA - eng PT - Journal Article DEP - 20260226 PL - Switzerland TA - Cancers (Basel) JT - Cancers JID - 101526829 PMC - PMC12985104 OTO - NOTNLM OT - lifestyle behaviour OT - oncology OT - paediatric cancer OT - survivorship COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/03/14 06:33 MHDA- 2026/03/14 06:34 PMCR- 2026/02/26 CRDT- 2026/03/14 01:03 PHST- 2026/01/13 00:00 [received] PHST- 2026/02/10 00:00 [revised] PHST- 2026/02/23 00:00 [accepted] PHST- 2026/03/14 06:34 [medline] PHST- 2026/03/14 06:33 [pubmed] PHST- 2026/03/14 01:03 [entrez] PHST- 2026/02/26 00:00 [pmc-release] AID - cancers18050752 [pii] AID - cancers-18-00752 [pii] AID - 10.3390/cancers18050752 [doi] PST - epublish SO - Cancers (Basel). 2026 Feb 26;18(5):752. doi: 10.3390/cancers18050752. PMID- 41827647 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260314 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 5 DP - 2026 Mar 9 TI - Physical Literacy-Focused Education Improves Fitness Markers in Preadolescents: Implications for School-Based Health Promotion. LID - 10.3390/healthcare14050695 [doi] LID - 695 AB - BACKGROUND/OBJECTIVES: Physical literacy (PL) is globally recognized as a foundational determinant of health status in children, but the effects of interventions based on PL were rarely studied in preadolescent children. The aim of this quasi-experimental, school-based study was to evaluate the potential effects of a PL intervention delivered during regular school hours on physical fitness (PF), physical literacy (PL), and physical activity (PA) in children aged 9 to 11 years from southern Croatia. METHODS: Participants were 125 preadolescents (57 girls), and were grouped into a control group (C = 70), and an experimental group (E, n = 55). The E group participated in a specific PL-focused education, integrated into regular physical education (PE) lessons as a 5-6 min substitute for standard PE content, over 12 weeks (36 PE classes in total). The C group participated in the standard PE curriculum. A pre-post-retention design was used, and the observed variables included anthropometrics (height, weight, BMI), PF (jumping power, abdominal strength, upper body strength, flexibility, mobility, and cardiovascular endurance), PL (evaluated by the PLAYself questionnaire), and indirectly measured PA (estimated via the PAQ-C questionnaire). Multivariate (MANOVA and univariate (ANOVA) analyses of variance for repeated measurements were used with time, gender, and group as the main effects, including their interactions. RESULTS: MANOVA calculated for a set of PF variables revealed significant main effects for time (F = 1361, p < 0.001) and a significant time x group interaction (F = 2.98, p < 0.05). Univariate ANOVA indicated specific intervention effects for jumping power and abdominal strength, favoring the E group. No significant differential effects were observed for PL or PA. CONCLUSIONS: The study demonstrated small, but statistically significant, improvements in PF indicators among children exposed to the PL-based intervention. Notably, the intervention was conducted in authentic school settings using standard resources, supporting the ecological validity and real-world applicability of the findings. FAU - Rajkovic Vuletic, Petra AU - Rajkovic Vuletic P AUID- ORCID: 0009-0008-1726-8704 AD - Faculty of Kinesiology, University of Split, 21000 Split, Croatia. AD - Faculty of Kinesiology, University of Zagreb, 10000 Zagreb, Croatia. FAU - Pranjic, Tomislav AU - Pranjic T AUID- ORCID: 0009-0002-2418-3027 AD - Faculty of Kinesiology, University of Split, 21000 Split, Croatia. FAU - Gilic Skugor, Barbara AU - Gilic Skugor B AUID- ORCID: 0000-0002-8868-7315 AD - Faculty of Kinesiology, University of Split, 21000 Split, Croatia. FAU - Lesnik, Blaz AU - Lesnik B AUID- ORCID: 0000-0002-0006-0092 AD - Faculty of Sport, University of Ljubljana, 10000 Ljubljana, Slovenia. FAU - Sekulic, Damir AU - Sekulic D AUID- ORCID: 0000-0001-8022-7886 AD - Faculty of Kinesiology, University of Split, 21000 Split, Croatia. FAU - Sajber, Dorica AU - Sajber D AD - Faculty of Sport, University of Ljubljana, 10000 Ljubljana, Slovenia. LA - eng GR - UIP-2025-02-3974/Croatian Science Foundation/ PT - Journal Article DEP - 20260309 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12984826 OTO - NOTNLM OT - health promotion OT - motor activity OT - pediatrics OT - quasi-experimental studies COIS- The authors declare no conflicts of interest. EDAT- 2026/03/14 06:31 MHDA- 2026/03/14 06:32 PMCR- 2026/03/09 CRDT- 2026/03/14 01:02 PHST- 2026/01/09 00:00 [received] PHST- 2026/02/25 00:00 [revised] PHST- 2026/03/06 00:00 [accepted] PHST- 2026/03/14 06:32 [medline] PHST- 2026/03/14 06:31 [pubmed] PHST- 2026/03/14 01:02 [entrez] PHST- 2026/03/09 00:00 [pmc-release] AID - healthcare14050695 [pii] AID - healthcare-14-00695 [pii] AID - 10.3390/healthcare14050695 [doi] PST - epublish SO - Healthcare (Basel). 2026 Mar 9;14(5):695. doi: 10.3390/healthcare14050695. PMID- 41827634 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260314 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 5 DP - 2026 Mar 7 TI - Feasibility and Acceptability of a Mindfulness App Intervention for Healthcare Worker Families Under Stress: A Pilot Micro-Randomized Trial. LID - 10.3390/healthcare14050681 [doi] LID - 681 AB - Background: This pilot study examined the feasibility, acceptability, usability, and preliminary outcomes of apt.mind, a mobile app-based mindfulness intervention with an exploratory smartwatch component, among healthcare worker families during the COVID-19 pandemic. Methods: Using a micro-randomized trial (MRT) design, 102 healthcare workers and co-parents of children aged 4-13 years were randomized once per day over 30 days to one of three conditions: (1) an audio-guided mindfulness exercise delivered via the apt.mind mobile app, (2) an in-app push notification prompting a brief mindfulness activity, or (3) no intervention. Feasibility was assessed through participant enrollment, retention, and daily engagement rates, while acceptability and usability were evaluated through qualitative and quantitative feedback. Exploratory multilevel analyses examined proximal effects of intervention conditions on momentary stress. Results: Retention was high, with all participants completing the 30-day protocol, and 80% of participants completed at least one daily survey. Participants reported moderate-to-high acceptability and usability. However, smartwatch battery life and sensor reliability limited the collection of usable physiological data. Multilevel analyses did not identify any significant main effects of intervention condition on momentary stress, but age moderated the association between the audio exercise condition and stress, benefiting older participants. Conclusions: Mobile-based mindfulness interventions appear feasible and acceptable for healthcare worker families in high-stress contexts. Although proximal stress effects were limited and exploratory, the findings inform future optimization of just-in-time adaptive interventions. Improvements in wearable technology and MRT implementation strategies are needed to enhance physiological data quality and reduce assessment-related anxiety. FAU - Lee, Sun-Kyung AU - Lee SK AUID- ORCID: 0000-0003-4830-3417 AD - T. Denny Sanford Harmony Institute, Arizona State University, Tempe, AZ 85287, USA. FAU - Basha, Sydni A J AU - Basha SAJ AUID- ORCID: 0000-0002-2252-6690 AD - Reach Institute, Department of Psychology, Arizona State University, Tempe, AZ 85287, USA. FAU - Cai, Qiyue AU - Cai Q AUID- ORCID: 0000-0001-8612-1759 AD - Reach Institute, Department of Psychology, Arizona State University, Tempe, AZ 85287, USA. FAU - Gewirtz, Abigail H AU - Gewirtz AH AUID- ORCID: 0000-0001-7376-2952 AD - Reach Institute, Department of Psychology, Arizona State University, Tempe, AZ 85287, USA. AD - Paul Baerwald School of Social Work, Hebrew University of Jerusalem, Jerusalem 9190501, Israel. LA - eng GR - CON000000081457/Lynne and Andrew Redleaf Family Foundation/ PT - Journal Article DEP - 20260307 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12984190 OTO - NOTNLM OT - acceptability OT - feasibility OT - healthcare workers OT - mindfulness intervention OT - wearable technology COIS- The authors declare no conflicts of interest. EDAT- 2026/03/14 06:34 MHDA- 2026/03/14 06:35 PMCR- 2026/03/07 CRDT- 2026/03/14 01:02 PHST- 2025/12/19 00:00 [received] PHST- 2026/02/14 00:00 [revised] PHST- 2026/03/04 00:00 [accepted] PHST- 2026/03/14 06:35 [medline] PHST- 2026/03/14 06:34 [pubmed] PHST- 2026/03/14 01:02 [entrez] PHST- 2026/03/07 00:00 [pmc-release] AID - healthcare14050681 [pii] AID - healthcare-14-00681 [pii] AID - 10.3390/healthcare14050681 [doi] PST - epublish SO - Healthcare (Basel). 2026 Mar 7;14(5):681. doi: 10.3390/healthcare14050681. PMID- 41827604 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260314 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 5 DP - 2026 Mar 4 TI - A Home-Based Strength Training Intervention for Stress and Depression Symptoms in Obese Latino Adolescent Males-A Pilot Study. LID - 10.3390/healthcare14050650 [doi] LID - 650 AB - Background: Obese Latino adolescents are at increased risk for stress and depressive symptomology, but interventions to target both physiological and mental health outcomes are scarce. This pilot randomized controlled trial assessed feasibility and preliminary efficacy for a home-based strength training (HBST) intervention on stress-related and mental health outcomes in obese Latino adolescent males. Methods: Fifty-two adolescents were randomized to HBST (n = 26) or control conditions (n = 26). Participants randomized to HBST completed a 16-week progressive resistance training intervention performed twice per week at home on non-consecutive days. Primary and secondary outcomes were assessed at baseline and immediately post-intervention and included measures of upper- and lower-body strength (1RM), body mass index (BMI), BMI percentile, BMI Z-score, salivary cortisol, depressive symptoms (CES-D), and perceived stress (PSS-14). Results are presented using completer-only analyses (n = 25) and mixed-design ANOVA models. An ANCOVA sensitivity analysis was conducted for depressive symptoms due to baseline imbalance, including baseline CES-D as a covariate in the model. Results: Recruitment goals were met, but retention was lower than expected (48% overall; HBST = 31%, control = 54%). Analyses revealed a significant Time x Group interaction for salivary cortisol (F(1, 20) = 5.70, p = 0.027, etap(2) = 0.222), such that cortisol decreased over time in HBST participants and increased in control participants. While all strength and anthropometric outcomes improved descriptively from baseline to follow-up in the intervention condition, no significant interactions were present between groups. Depressive symptoms also decreased descriptively in HBST participants, but this effect was no longer significant after adjusting for baseline CES-D using ANCOVA (F(1, 19) = 0.002, p = 0.968). There were no significant findings for perceived stress. Conclusions: Differential effects were observed on salivary cortisol, suggesting HBST may be feasible in obese Latino adolescents. However, results should be interpreted with caution given baseline imbalance, small sample size, high attrition, and limitations with measuring cortisol at one time point without adjustment for time of day or key psychosocial and physiological confounders. All psychological and anthropometric outcomes were exploratory and non-significant after adjustment. A larger, multisite trial using baseline-adjusted analytic procedures, repeated physiological sampling, objective measures of adherence, and extended follow-up is needed to determine whether HBST produces meaningful effects that are sustained over time. FAU - Kelly, Louise A AU - Kelly LA AUID- ORCID: 0000-0003-1013-5024 AD - Health Disparities Research Laboratory, Exercise Science Department, California Lutheran University, Thousand Oaks, CA 91360, USA. FAU - Dominguez, Angela Martinez AU - Dominguez AM AD - Health Disparities Research Laboratory, Exercise Science Department, California Lutheran University, Thousand Oaks, CA 91360, USA. FAU - McMillan, Muireann I AU - McMillan MI AD - Health Disparities Research Laboratory, Exercise Science Department, California Lutheran University, Thousand Oaks, CA 91360, USA. FAU - Petersen, Rory AU - Petersen R AD - Health Disparities Research Laboratory, Exercise Science Department, California Lutheran University, Thousand Oaks, CA 91360, USA. FAU - Facey, Vanessa AU - Facey V AD - Health Disparities Research Laboratory, Exercise Science Department, California Lutheran University, Thousand Oaks, CA 91360, USA. FAU - Bolio, Miguelangel AU - Bolio M AD - Health Disparities Research Laboratory, Exercise Science Department, California Lutheran University, Thousand Oaks, CA 91360, USA. FAU - Hugo, Brooke AU - Hugo B AD - Health Disparities Research Laboratory, Exercise Science Department, California Lutheran University, Thousand Oaks, CA 91360, USA. LA - eng GR - U54 CA 116848/National Institute of Cancer/ PT - Journal Article DEP - 20260304 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12984334 OTO - NOTNLM OT - adolescents OT - obesity OT - pilot study OT - psychosocial health OT - salivary cortisol OT - strength training COIS- The authors declare no conflicts of interest. EDAT- 2026/03/14 06:33 MHDA- 2026/03/14 06:34 PMCR- 2026/03/04 CRDT- 2026/03/14 01:02 PHST- 2026/02/02 00:00 [received] PHST- 2026/02/21 00:00 [revised] PHST- 2026/03/01 00:00 [accepted] PHST- 2026/03/14 06:34 [medline] PHST- 2026/03/14 06:33 [pubmed] PHST- 2026/03/14 01:02 [entrez] PHST- 2026/03/04 00:00 [pmc-release] AID - healthcare14050650 [pii] AID - healthcare-14-00650 [pii] AID - 10.3390/healthcare14050650 [doi] PST - epublish SO - Healthcare (Basel). 2026 Mar 4;14(5):650. doi: 10.3390/healthcare14050650. PMID- 41827589 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260314 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 5 DP - 2026 Mar 3 TI - Intergenerational Mealtimes in Adult Day Care Settings: Impact of a Pilot Randomised Control Study on the Well-Being, Health, and Food Intake of Older Adults. LID - 10.3390/healthcare14050635 [doi] LID - 635 AB - Background/Objectives: Empirical evidence on intergenerational commensality in institutional care settings remains scarce. This pilot and feasibility study evaluated the preliminary impact of an innovative intergenerational mealtime model on older adults' subjective well-being, self-esteem, perceived health, and food consumption in an adult day care setting. Methods: A 16-week wait-list randomised controlled pilot trial with a sequential explanatory mixed-methods design was conducted in an intergenerational centre in southern Spain. Twenty-two older adults who reside in a community living setting and attend a day care service were randomly assigned to two intergenerational dining intervention/waiting-list groups or a control group. Participants in the intervention/waiting-list groups had lunch four times per week with children 2-3 years of age, following a structured protocol. The quantitative outcomes examined included subjective well-being (WHO-5 Well-Being Index), self-esteem (Rosenberg scale), perceived health (EuroQol EQ-5D), and objective assessment of plate leftovers using photographic records and the Comstock visual estimation method. Qualitative data were collected through semi-structured interviews and ethnographic observation. The trial was registered at ClinicalTrials.gov (NCT06996418). Results: Across the study period, intervention, waiting-list, and control groups showed preliminary improvements in subjective well-being and self-esteem, but with no significant group-by-time interaction. In contrast, mixed-effects models revealed an encouraging significant reduction in plate leftovers among older adults during intergenerational meals, particularly in second courses. The reduction was consolidated during the post-intervention follow-up. Qualitative findings showed perceived improvements in emotional well-being, motivation, and appetite, thus highlighting potential relational and affective mechanisms underlying changes in eating behaviour. Conclusions: This pilot study shows promise for intergenerational commensality in adult day care settings and provides preliminary evidence of its potential to promote well-being and self-esteem and reduce food waste among older adults. Larger, multi-centre, appropriately powered trials are warranted to validate these findings. FAU - Lopez-Lopez, Raul AU - Lopez-Lopez R AD - Department of Sociology, University of Granada, 18071 Granada, Granada, Spain. FAU - Artacho, Reyes AU - Artacho R AUID- ORCID: 0000-0001-6405-9480 AD - Department of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, 18071 Granada, Granada, Spain. FAU - Rodriguez-Perez, Celia AU - Rodriguez-Perez C AUID- ORCID: 0000-0002-7233-6481 AD - Department of Nutrition and Food Science, Faculty of Pharmacy, University of Granada, 18071 Granada, Granada, Spain. AD - Institute of Nutrition and Food Technology (INYTA) 'Jose Mataix', Biomedical Research Centre, University of Granada, Avda. del Conocimiento s/n, 18100 Granada, Granada, Spain. AD - Instituto de Investigacion Biosanitaria ibs. GRANADA, Avenida de Madrid, 15, 18012 Granada, Granada, Spain. FAU - Justicia-Garcia, Judith AU - Justicia-Garcia J AD - Nestle Espana S.A., 08950 Esplugues de Llobregat, Barcelona, Spain. FAU - Carrillo, Alicia AU - Carrillo A AD - Macrosad, Parque Cientifico y Tecnologico Geolit, Av. De la Innovacion, 3, 23260 Mengibar, Jaen, Spain. FAU - Sanchez, Mariano AU - Sanchez M AUID- ORCID: 0000-0002-1129-9525 AD - Department of Sociology, University of Granada, 18071 Granada, Granada, Spain. AD - Macrosad Chair in Intergenerational Studies, Faculty of Political Sciences and Sociology, University of Granada, 18071 Granada, Granada, Spain. LA - eng SI - ClinicalTrials.gov/NCT06996418 GR - OTRI-6474 "Intergenerational dining rooms: proof of concept, prototyping, small-scale piloting, and validation."/Nestle Espana S.A./ PT - Journal Article DEP - 20260303 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12984263 OTO - NOTNLM OT - intergenerational commensality OT - leftover food OT - mixed methods OT - older adults OT - perceived health OT - pilot randomised controlled trial OT - self-esteem OT - subjective well-being COIS- Alicia Carrillo is employed at Macrosad. Judith Justicia-Garcia is an employee of Nestle Espana S.A. However, it is declared that none of these coauthors were directly involved on study design, implementation, and interpretation. Both of them played the role of follow-up persons on behalf of funding stakeholders. Mariano Sanchez is an external scientific consultant to initiatives by Macrosad. Raul Lopez-Lopez, Reyes Artacho, and Celia Rodriguez declare no conflicts of interest. EDAT- 2026/03/14 06:33 MHDA- 2026/03/14 06:34 PMCR- 2026/03/03 CRDT- 2026/03/14 01:02 PHST- 2025/12/31 00:00 [received] PHST- 2026/02/24 00:00 [revised] PHST- 2026/02/28 00:00 [accepted] PHST- 2026/03/14 06:34 [medline] PHST- 2026/03/14 06:33 [pubmed] PHST- 2026/03/14 01:02 [entrez] PHST- 2026/03/03 00:00 [pmc-release] AID - healthcare14050635 [pii] AID - healthcare-14-00635 [pii] AID - 10.3390/healthcare14050635 [doi] PST - epublish SO - Healthcare (Basel). 2026 Mar 3;14(5):635. doi: 10.3390/healthcare14050635. PMID- 41827527 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260314 LR - 20260813 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 5 DP - 2026 Feb 25 TI - Iron Deficiency Anemia in Infants-Diagnostic Challenge and Assessment of Dietary Impact on Its Prevalence. LID - 10.3390/healthcare14050574 [doi] LID - 574 AB - Background/Objectives: Iron deficiency affects 2% of infants under six months of age and 4-18% of infants aged 6-12 months and may lead to anemia. Given the consequences of iron deficiency in infancy and the importance of adequate nutrition, this study aimed to assess indicators of iron metabolism in infants whose parents participated in nutritional education. Methods: The study included 104 infants, divided into a study group (SG, n = 52) receiving a nutritional education intervention and a control group (CG, n = 52). Peripheral blood morphology parameters and biochemical markers, e.g., iron status (serum iron, transferrin, ferritin, and hepcidin), were evaluated at 3 and 12 months of age. Additionally, at study end, parents completed a three-day dietary diary to assess their infant's iron intake. Results: After nearly one year of intervention, no cases of anemia based on hemoglobin concentration were identified in either group. However, infants in the SG were less likely to present iron and ferritin concentrations below reference ranges compared to the CG. In the CG, low ferritin levels occurred more frequently at 12 months than at baseline. This finding may be related to higher dietary iron intake in the SG, as insufficient iron intake was more common among the CG. Heatmap analysis revealed strong positive correlations among erythrocyte indices, confirming their internal consistency. No single parameter emerged as a superior marker of iron deficiency, emphasizing the need for a combined assessment of iron status. Conclusions: Parental nutritional education may improve iron status and reduce the risk of iron metabolism disorders in infants. FAU - Ilnicka-Borowczyk, Kinga AU - Ilnicka-Borowczyk K AD - Department of Bromatology, Poznan University of Medical Sciences, Marcelinska 42, 60-354 Poznan, Poland. AD - Complex of Healthcare Institutions, Kosciuszki 96, 64-700 Czarnkow, Poland. FAU - Dobrzynska, Malgorzata AU - Dobrzynska M AUID- ORCID: 0000-0001-9589-522X AD - Department of Bromatology, Poznan University of Medical Sciences, Marcelinska 42, 60-354 Poznan, Poland. FAU - Kaczmarek-Kryszak, Katarzyna A AU - Kaczmarek-Kryszak KA AUID- ORCID: 0009-0009-9329-6317 AD - Department of Bromatology, Poznan University of Medical Sciences, Marcelinska 42, 60-354 Poznan, Poland. FAU - Szczepanska-Alvarez, Anna AU - Szczepanska-Alvarez A AUID- ORCID: 0000-0001-9428-8938 AD - Department of Mathematical and Statistical Methods, Poznan University of Life Sciences, 60-637 Poznan, Poland. FAU - Podgorski, Tomasz AU - Podgorski T AUID- ORCID: 0000-0003-0745-4606 AD - Department of Biochemistry, Poznan University of Physical Education, 61-871 Poznan, Poland. FAU - Osipa, Jagoda AU - Osipa J AD - Department of Bromatology, Poznan University of Medical Sciences, Marcelinska 42, 60-354 Poznan, Poland. AD - Complex of Healthcare Institutions, Kosciuszki 96, 64-700 Czarnkow, Poland. FAU - Markowska, Hanna AU - Markowska H AUID- ORCID: 0009-0006-7837-1989 AD - Department of Bromatology, Poznan University of Medical Sciences, Marcelinska 42, 60-354 Poznan, Poland. AD - Complex of Healthcare Institutions, Kosciuszki 96, 64-700 Czarnkow, Poland. FAU - Wozniak, Dagmara AU - Wozniak D AUID- ORCID: 0000-0002-0204-0220 AD - Department of Bromatology, Poznan University of Medical Sciences, Marcelinska 42, 60-354 Poznan, Poland. FAU - Drzymala-Czyz, Slawomira AU - Drzymala-Czyz S AUID- ORCID: 0000-0001-8291-5439 AD - Department of Bromatology, Poznan University of Medical Sciences, Marcelinska 42, 60-354 Poznan, Poland. LA - eng GR - RG 1/2022/Fundacja NUTRICIA/ PT - Journal Article DEP - 20260225 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12984742 OTO - NOTNLM OT - child nutrition OT - development OT - educational intervention OT - ferritin OT - hepcidin OT - nutritional programming OT - transferrin COIS- The authors declare no conflicts of interest. EDAT- 2026/03/14 06:33 MHDA- 2026/03/14 06:34 PMCR- 2026/02/25 CRDT- 2026/03/14 01:02 PHST- 2026/01/20 00:00 [received] PHST- 2026/02/08 00:00 [revised] PHST- 2026/02/23 00:00 [accepted] PHST- 2026/03/14 06:34 [medline] PHST- 2026/03/14 06:33 [pubmed] PHST- 2026/03/14 01:02 [entrez] PHST- 2026/02/25 00:00 [pmc-release] AID - healthcare14050574 [pii] AID - healthcare-14-00574 [pii] AID - 10.3390/healthcare14050574 [doi] PST - epublish SO - Healthcare (Basel). 2026 Feb 25;14(5):574. doi: 10.3390/healthcare14050574. PMID- 41827078 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 1749-799X (Electronic) IS - 1749-799X (Linking) VI - 21 IP - 1 DP - 2026 Mar 13 TI - Cross-education effects of healthy-side lower-limb strength training on neuromuscular function recovery following anterior cruciate ligament reconstruction: a randomized controlled trial. LID - 10.1186/s13018-026-06776-6 [doi] LID - 269 AB - OBJECTIVE: Based on cross-education theory, this study aimed to investigate whether Healthy-Side Lower-Limb Strength Training could promote neuromuscular function recovery of the injured limb in patients following anterior cruciate ligament reconstruction (ACLR) through central nervous system-mediated contralateral adaptive mechanisms. METHODS: A single-masked, randomized controlled trial was conducted with 40 patients at 5-6 weeks post-ACLR, who were randomly allocated to intervention and control groups (n = 20). The control group received conventional rehabilitation, while the intervention group received conventional rehabilitation plus Healthy-Side Lower-Limb Strength Training for 6 weeks. The Lysholm knee function score was used to assess knee joint function at baseline and post-intervention. A wireless surface electromyography system was used to measure root mean square (RMS) values of bilateral rectus femoris, semitendinosus, tibialis anterior, and lateral gastrocnemius muscles during maximal voluntary contraction and level walking. The activation ratios of the flexor and extensor muscle groups were calculated to evaluate muscle synergy patterns. The effects of Healthy-side strength training on bilateral lower limb muscle activation patterns and knee joint function were assessed through within-group pre- and post-intervention comparisons and between-group analyses. RESULTS: Following the 6-week intervention, Lysholm knee function scores improved significantly in both groups, with the intervention group demonstrating a significantly greater magnitude of improvement than the control group (P < 0.01). At baseline, the RMS values of all recorded muscles on the affected side were significantly lower than those on the unaffected side during both MVC and level walking in both groups (P < 0.01). Following the intervention, the intervention group demonstrated significant reductions in affected-to-unaffected limb asymmetry across all four muscle groups during both MVC and level walking (P < 0.01), whereas the control group exhibited significant asymmetry reductions in only a limited number of muscle groups during MVC alone (P < 0.01). In the intervention group, the RMS values of the bilateral rectus femoris, semitendinosus, tibialis anterior, and lateral gastrocnemius increased significantly during both MVC and level walking relative to baseline (P < 0.05). In contrast, the control group demonstrated significant improvements in only a limited subset of muscle groups. Between-group post-intervention comparisons revealed that the intervention group achieved significantly higher activation levels in the unaffected-side rectus femoris, bilateral semitendinosus, and unaffected-side tibialis anterior than the control group (P < 0.05). Both groups exhibited a declining trend in flexor-extensor co-contraction ratios; however, neither between-group nor within-group differences reached statistical significance (P > 0.05). CONCLUSION: Healthy-Side Lower-Limb Strength Training effectively promoted knee joint function recovery and enhanced bilateral lower limb muscle activation in patients following ACLR through cross-education mechanisms. These findings validate the clinical utility of cross-education theory and support Healthy-side strength training as an innovative rehabilitation strategy for early post-ACLR recovery. TRIAL REGISTRATION: Chinese Clinical Trial Registry ChiCTR2400087325. Registered on 25/07/2024. CI - (c) 2026. The Author(s). FAU - Liu, Chao AU - Liu C AD - Department of Sports Training, Tianjin University of Sport, Tianjin, China. FAU - Sun, ZiHao AU - Sun Z AD - Department of Special Education and Rehabilitation, Binzhou Medical University, Yantai City, Shandong Province, China. FAU - Jiang, XiangZhan AU - Jiang X AD - Department of Special Education and Rehabilitation, Binzhou Medical University, Yantai City, Shandong Province, China. FAU - Liu, BaoHua AU - Liu B AD - Department of Social Sports, Tianjin University of Sport, Tianjin, China. liubaohua8259@163.com. FAU - Zhao, YueHan AU - Zhao Y AD - Department of Rehabilitation Medicine, The Affiliated Hospital of Qingdao University, Qingdao, China. Aa19861802747@163.com. LA - eng GR - KFKT-2023-026/Science and Technology Development Project of the Chinese Association of Rehabilitation Medicine/ GR - 23ZYJ0228/2023 Higher Education Science Research Plan Project of the China Association of Higher Education/ GR - 50012304488/Scientific Foundation of Binzhou Medical University/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20260313 PL - England TA - J Orthop Surg Res JT - Journal of orthopaedic surgery and research JID - 101265112 SB - IM MH - Humans MH - *Resistance Training/methods MH - Male MH - Female MH - *Anterior Cruciate Ligament Reconstruction/rehabilitation MH - Single-Blind Method MH - *Recovery of Function/physiology MH - Adult MH - Young Adult MH - *Lower Extremity/physiology MH - Muscle, Skeletal/physiology MH - Muscle Strength/physiology MH - Electromyography MH - Adolescent MH - Treatment Outcome MH - *Anterior Cruciate Ligament Injuries/surgery/physiopathology/rehabilitation MH - Knee Joint/physiopathology PMC - PMC13097873 OTO - NOTNLM OT - Anterior cruciate ligament reconstruction OT - Cross-education OT - Healthy-side strength training OT - Muscle activation OT - Neuroplasticity OT - Surface electromyography COIS- Declarations. Ethics approval and consent to participate: The studies involving human participants were reviewed and approved by the Ethics Committee of the Affiliated Hospital of Binzhou Medical University. The patients/participants provided their written informed consent to participate in this study. Consent for publication: Written informed consent for publication was obtained from all participants. The participant in Figs. 1, 2, 3 and 4 specifically consented to publication of this de-identified image, which does not display facial features or any personally identifiable information. Consent for publication: Participants give their consent for publication of their image if require. Competing interests: The authors declare no competing interests. EDAT- 2026/03/14 06:33 MHDA- 2026/04/22 00:34 PMCR- 2026/03/13 CRDT- 2026/03/14 00:56 PHST- 2025/12/30 00:00 [received] PHST- 2026/02/18 00:00 [accepted] PHST- 2026/04/22 00:34 [medline] PHST- 2026/03/14 06:33 [pubmed] PHST- 2026/03/14 00:56 [entrez] PHST- 2026/03/13 00:00 [pmc-release] AID - 10.1186/s13018-026-06776-6 [pii] AID - 6776 [pii] AID - 10.1186/s13018-026-06776-6 [doi] PST - epublish SO - J Orthop Surg Res. 2026 Mar 13;21(1):269. doi: 10.1186/s13018-026-06776-6. PMID- 41827029 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 23 IP - 1 DP - 2026 Mar 13 TI - Recess and after-hours behavior patterns associated with community schoolyard transformations. LID - 10.1186/s12966-026-01899-9 [doi] LID - 25 AB - BACKGROUND: Spending time in nature and physical activity are both linked to better health outcomes for children. School environments provide the potential for multiple interventions to promote healthy behaviors. Transforming these existing public spaces to serve broader activity functions provides opportunities to support healthy child development and to increase nature access for local communities. METHODS: Our quasi-experimental design capitalized on a community-engaged schoolyard redesign and redevelopment project completed at two elementary schools in Tacoma, Washington, USA, led by the Trust for Public Land. Renovations included painting paved surfaces, installation of new play structures, adding walking paths and log seating areas, and planting trees. We used a validated momentary time sampling observational tool, the System for Observing Outdoor Play Environments in Neighborhood schools (SOOPEN), before and after for two schools undergoing the transformation and a control school. Moderate-to-vigorous physical activity (MVPA) and within-group behaviors in the schoolyard were observed. We used a difference-in-difference approach to estimate the effect of the schoolyard renovation on behavior during recess, and on community use of the schoolyard outside of school hours. RESULTS: The schoolyard transformation was associated with a 1.51-times greater increase (95% CI: 0.95, 2.40) in MVPA during recess at intervention schools compared to the control school, although this association was only statistically significant among groups of boys. After renovation, MVPA was highest in grassy areas at one school (69%), but highest in paved zones with newly painted markings at the other (75%). Renovations were not associated with changes in the prevalence of prosocial behavior during recess, which was high at baseline. The schoolyard transformation was also associated with increased community use outside of school hours, especially for groups of children (5.8-times [95% CI: 1.4, 23.8] greater increase in use over time at renovation schools compared to the control school). CONCLUSIONS: Schoolyard transformations have the potential to increase schoolyard use and physical activity both during and outside of school hours, if campuses are open to community use. Additional rigorous research can inform future projects to support the health of school-age children and address inequities in distribution of community greenspaces. FAU - Hazlehurst, Marnie F AU - Hazlehurst MF AD - Seattle Children's Research Institute, Seattle, WA, USA. FAU - Wolf, Kathleen L AU - Wolf KL AD - University of Washington, Seattle, WA, USA. FAU - Simmons, Cary AU - Simmons C AD - Trust for Public Land, Washington, DC, USA. FAU - Evans, Sarneshea AU - Evans S AD - Trust for Public Land, Washington, DC, USA. FAU - Steiner, Mary Kathleen AU - Steiner MK AD - Seattle Children's Research Institute, Seattle, WA, USA. FAU - Garrett, Kimberly A AU - Garrett KA AD - Seattle Children's Research Institute, Seattle, WA, USA. FAU - Tandon, Pooja S AU - Tandon PS AD - Seattle Children's Research Institute, Seattle, WA, USA. pooja.tandon@seattlechildrens.org. AD - Trust for Public Land, Washington, DC, USA. pooja.tandon@seattlechildrens.org. AD - Department of Pediatrics, University of Washington, Seattle, WA, USA. pooja.tandon@seattlechildrens.org. LA - eng PT - Journal Article DEP - 20260313 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - *Schools MH - Child MH - Play and Playthings MH - *Exercise MH - *Environment Design MH - Washington MH - *Neighborhood Characteristics MH - *Health Behavior MH - Male MH - Residence Characteristics MH - *Child Behavior PMC - PMC13001272 OTO - NOTNLM OT - Green schoolyards OT - Physical activity OT - Schools OT - Shared use COIS- Declarations. Ethics approval and consent to participate: Both the Seattle Children's Hospital (STUDY00002677) and University of Washington (STUDY00011253) Institutional Review Boards approved this study and determined it to be exempt. Tacoma Public Schools' Data and Assessment Research Team and leadership at each school agreed to data collection on their campus by study staff. Consent for publication: Not applicable. Competing interests: C.S., S.E., and P.T. work for Trust for Public Land (TPL), an organization focused on protecting land and creating parks for people, which could be considered a competing interest given the aims of this paper. TPL also provided funding for follow-up data collection and analysis. The authors declare that they have no other competing interests. EDAT- 2026/03/14 06:31 MHDA- 2026/06/28 06:35 PMCR- 2026/03/13 CRDT- 2026/03/14 00:53 PHST- 2025/04/01 00:00 [received] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/06/28 06:35 [medline] PHST- 2026/03/14 06:31 [pubmed] PHST- 2026/03/14 00:53 [entrez] PHST- 2026/03/13 00:00 [pmc-release] AID - 10.1186/s12966-026-01899-9 [pii] AID - 1899 [pii] AID - 10.1186/s12966-026-01899-9 [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2026 Mar 13;23(1):25. doi: 10.1186/s12966-026-01899-9. PMID- 41826924 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Mar 13 TI - Study protocol for a theory-informed randomized controlled trial of a lifestyle and sleep intervention to improve quality of life and physical activity in inactive adults: the SleeP exercIse nutRition heALth+ SPIRAL+ study. LID - 10.1186/s12889-026-26959-4 [doi] LID - 1297 AB - BACKGROUND: Sleep, physical activity, and diet are key determinants of health, each independently associated with chronic disease risk and mortality. These behaviors also interact: insufficient sleep can impair physical activity and dietary choices, while regular exercise and healthy diet promote better sleep. Although lifestyle interventions commonly target physical activity and diet, few simultaneously address sleep. Emerging evidence suggests that even small improvements across all three behaviors can reduce all-cause mortality, highlighting the potential of multi-behavior approaches. However, the effects of a lifestyle intervention simultaneously targeting sleep, physical activity, and diet on quality of life and physical activity levels in inactive adults remain largely unexplored. METHODS: The SPIRAL+ study is a single-center, randomized controlled trial conducted in France, among non-exercising adults aged 18-80 years. Participants (n = 201) will be randomized to one of three groups: (1) lifestyle intervention (physical activity and diet) (2), lifestyle plus sleep intervention, or (3) control. Assessments will be conducted at baseline, 6 months (post-intervention), and 12 months. The primary outcomes are health-related quality of life (EQ-5D-5 L) and daily step count (measured by accelerometer) assessed immediately after the 6-month intervention. Secondary outcomes include whether intervention effects are sustained at 12 months, along with markers of physical fitness (cardiorespiratory fitness, body composition, handgrip strength), physical activity and sedentary behavior (accelerometry), and sleep (home-based sleep test, actigraphy, and validated questionnaires). Additional self-reported outcomes will cover diet, mental wellbeing, motivation, quality of life, and psychological constructs related to health behavior change. A qualitative component will explore barriers and facilitators to adherence through semi-structured interviews. DISCUSSION: This trial will evaluate whether adding a sleep component to a lifestyle intervention improves quality of life and physical activity levels in inactive adults. If effective, the findings will support the integration of sleep into multi-behavior interventions to enhance health outcomes and inform future public health strategies. TRIAL REGISTRATION: Clinical Trials NCT06424847. FAU - Mendelson, Monique AU - Mendelson M AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. monique.mendelson@univ-grenoble-alpes.fr. FAU - Coudurier, Marie AU - Coudurier M AD - Sports & Pathology Department, CHU Grenoble Alpes, Echirolles, France. FAU - Doutreleau, Stephane AU - Doutreleau S AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. AD - Sports & Pathology Department, CHU Grenoble Alpes, Echirolles, France. FAU - Guinot, Michel AU - Guinot M AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. AD - Sports & Pathology Department, CHU Grenoble Alpes, Echirolles, France. FAU - Flore, Patrice AU - Flore P AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. FAU - Bailly, Sebastien AU - Bailly S AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. FAU - Baillieul, Sebastien AU - Baillieul S AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. AD - Laboratoire Du Sommeil, Pole Thorax et Vaisseaux, CHU Grenoble Alpes, Grenoble, France. FAU - Destors, Marie AU - Destors M AD - Laboratoire Du Sommeil, Pole Thorax et Vaisseaux, CHU Grenoble Alpes, Grenoble, France. FAU - Tamisier, Renaud AU - Tamisier R AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. AD - Laboratoire Du Sommeil, Pole Thorax et Vaisseaux, CHU Grenoble Alpes, Grenoble, France. FAU - Pepin, Jean-Louis AU - Pepin JL AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. AD - Laboratoire Du Sommeil, Pole Thorax et Vaisseaux, CHU Grenoble Alpes, Grenoble, France. FAU - Tessier, Damien AU - Tessier D AD - Univ. Grenoble-Alpes, SENS, Grenoble, France. FAU - Roustit, Matthieu AU - Roustit M AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. AD - Inserm CIC 1406, Grenoble Alps University Hospital, Univ. Grenoble Alps, Grenoble, France. FAU - Manceau, Marc AU - Manceau M AD - Inserm CIC 1406, Grenoble Alps University Hospital, Univ. Grenoble Alps, Grenoble, France. FAU - Chalabaev, Aina AU - Chalabaev A AD - Univ. Grenoble-Alpes, SENS, Grenoble, France. FAU - Verges, Samuel AU - Verges S AD - Univ. Grenoble Alps, HP2 Laboratory, Inserm U1300, Grenoble, France. LA - eng SI - ClinicalTrials.gov/NCT06424847 GR - SIP/Institut pour la Recherche en Sante Publique/ GR - ANR-15-IDEX-02/Agence Nationale de la Recherche/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20260313 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Quality of Life MH - Adult MH - Middle Aged MH - *Exercise/psychology MH - *Sleep MH - Adolescent MH - Young Adult MH - Female MH - Aged MH - Male MH - *Life Style MH - Randomized Controlled Trials as Topic MH - France MH - *Sedentary Behavior MH - Aged, 80 and over MH - Diet MH - *Health Promotion/methods PMC - PMC13097937 OTO - NOTNLM OT - lifestyle intervention OT - physical activity OT - quality of life OT - sleep COIS- Declarations. Ethics approval and consent to participate: This study was approved by the French national ethics committee (Comite de protection des personnes Sud-Est I) on March 24th 2024. Notification of the Committee's approval was forwarded to the National Medicines Safety Agency (ANSM) by the sponsor (Grenoble Alpes University Hospital, Delegation for Clinical Research and Innovation). Moreover, the study was registered on Clinical-Trials.gov (NCT06424847) on 16/05/2024. The protocol was amended on February 13th 2025 in order to reduce the number of questionnaires, and add precisions regarding inclusion criteria. The current protocol is version 2 (13/02/2025). All potential major changes to the protocol will be reported to the relevant regulatory authorities All participants that volunteer will be asked to sign a written informed consent prior to program participation with a study investigator. The sponsor and investigators commit to conducting the clinical investigation in compliance with French law (Law n degrees 2012-300, March 5, 2012), European Regulation n degrees 2017/745, ISO Standard 14155:2020, and the Declaration of Helsinki. Investigators will ensure proper consent collection and adverse event reporting. The sponsor will be in charge of auditing and monitoring. Data will be processed in compliance with French data protection laws (Law no. 78-17 of 1978, amended by law no. 2018-493) and the EU GDPR (Regulation 2016/679). This investigation complies with the Reference Methodology" (MR-001) per article 54(5) of the amended 1978 law and has authorization from the National Commission for Information Technology and Civil Liberties (CNIL). The sponsor of the study has committed to adhering to this methodology and has obtained dedicated insurance coverage. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/14 06:33 MHDA- 2026/06/28 00:37 PMCR- 2026/03/13 CRDT- 2026/03/14 00:48 PHST- 2025/10/01 00:00 [received] PHST- 2026/03/06 00:00 [accepted] PHST- 2026/06/28 00:37 [medline] PHST- 2026/03/14 06:33 [pubmed] PHST- 2026/03/14 00:48 [entrez] PHST- 2026/03/13 00:00 [pmc-release] AID - 10.1186/s12889-026-26959-4 [pii] AID - 26959 [pii] AID - 10.1186/s12889-026-26959-4 [doi] PST - epublish SO - BMC Public Health. 2026 Mar 13;26(1):1297. doi: 10.1186/s12889-026-26959-4. PMID- 41826886 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Mar 13 TI - Enhancing personal capacities in families with or at risk of type 2 diabetes: qualitative investigation of the GO EASY intervention. LID - 10.1186/s12889-026-26951-y [doi] LID - 1303 AB - BACKGROUND: A family-centered intervention, GO EASY, targeting physical activity and eating habits in families of adults with or at risk of type 2 diabetes and their children, was feasibility tested, but user perspectives have not been reported. OBJECTIVES: To explore how parents and children experienced participating in the GO EASY intervention and its impact on their everyday lives. METHODS: This study employed a phenomenological-hermeneutical approach, involving nine individual interviews conducted with six parents and three children representing three families (50% of the study sample) at three- and six-month post-baseline, from June to October 2024. A Ricoeur-inspired analysis was conducted using naive reading, structural analysis, and critical interpretation. RESULTS: The analysis revealed two themes: "The family club is a source of encouragement", with subthemes "Sharing challenges with peers is valuable" and "Facilitating acceptance and confidence"; and "A helpful intervention for families", with subthemes "Heading in the same direction" and "Making space for quality family time". The GO EASY intervention fostered emotionally safe environments for sharing experiences and mutual support. Enhanced motivation and skill development enabled the participants to live more actively and healthily. Beyond the immediate goals, families strengthened their social networks. CONCLUSION: The intervention fostered a sense of togetherness that boosted participants' motivation, helped families build skills for healthier daily routines, and broadened their social networks. The findings suggest a positive impact on participants' capacities, potentially beneficial for health competence and resilience. More rigorous, user-informed research is needed to understand intergenerational dynamics and outcomes in family-centered, community-based health interventions. TRIAL REGISTRATION: NCT05694351(ClinicalTrials.gov), Registered January 18, 2023. FAU - Nielsen, Svetlana Solgaard AU - Nielsen SS AUID- ORCID: 0000-0002-3694-4236 AD - The Research and Implementation Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Central and West Zealand Hospital, Faelledvej 6, 4., Slagelse, 4200, Denmark. ssolgaard@health.sdu.dk. AD - Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark. ssolgaard@health.sdu.dk. FAU - Agerskov, Hanne AU - Agerskov H AUID- ORCID: 0000-0002-3271-0686 AD - Department of Clinical Research, University of Southern Denmark, Odense, Denmark. AD - Department of Nephrology, Odense University Hospital, Kloevervaenget 6, 11, Odense, 5000, Denmark. AD - Family focused healthcare research Center (FaCe), University of Southern Denmark, Odense, Denmark. FAU - Skou, Soren T AU - Skou ST AUID- ORCID: 0000-0003-4336-7059 AD - The Research and Implementation Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Central and West Zealand Hospital, Faelledvej 6, 4., Slagelse, 4200, Denmark. AD - Center for Muscle and Joint Health, Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark. FAU - Sunddahl, Louise Degn Kjolbo AU - Sunddahl LDK AUID- ORCID: 0009-0003-1750-3691 AD - The Research and Implementation Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Central and West Zealand Hospital, Faelledvej 6, 4., Slagelse, 4200, Denmark. FAU - Kjaergaard, Erna AU - Kjaergaard E AUID- ORCID: 0009-0007-3711-3876 AD - The Research and Implementation Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Central and West Zealand Hospital, Faelledvej 6, 4., Slagelse, 4200, Denmark. FAU - Simony, Charlotte AU - Simony C AUID- ORCID: 0000-0003-1189-2967 AD - The Research and Implementation Unit PROgrez, Department of Physiotherapy and Occupational Therapy, Central and West Zealand Hospital, Faelledvej 6, 4., Slagelse, 4200, Denmark. AD - Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark. LA - eng SI - ClinicalTrials.gov/NCT05694351 PT - Journal Article DEP - 20260313 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/prevention & control MH - Female MH - Qualitative Research MH - Male MH - *Health Promotion/methods MH - Adult MH - Exercise MH - Child MH - Interviews as Topic MH - Feeding Behavior/psychology MH - Family Support MH - Middle Aged MH - *Parents/psychology MH - Social Support PMC - PMC13101193 OTO - NOTNLM OT - Community-based participatory research OT - Diabetes mellitus OT - Health behavior OT - Health promotion OT - Healthy lifestyle OT - User-centered design COIS- Declarations. Ethics approval and consent to participate: The Health Research Ethics Committee in Region Zealand (SJ-1037) and the Data Protection Authority in Region Zealand (REG-002-2023) have approved the study, which followed the Declaration of Helsinki principles [61]. Before inclusion, all families received detailed written and oral information on the feasibility study objectives and activities. Informed consent forms were signed by each parent or parent authority holder (also if not participating) for their own and their child's participation. Additionally, children aged 15-17 years signed a separate age-specific informed consent form. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/14 06:32 MHDA- 2026/06/27 12:38 PMCR- 2026/03/13 CRDT- 2026/03/14 00:46 PHST- 2025/11/27 00:00 [received] PHST- 2026/03/05 00:00 [accepted] PHST- 2026/06/27 12:38 [medline] PHST- 2026/03/14 06:32 [pubmed] PHST- 2026/03/14 00:46 [entrez] PHST- 2026/03/13 00:00 [pmc-release] AID - 10.1186/s12889-026-26951-y [pii] AID - 26951 [pii] AID - 10.1186/s12889-026-26951-y [doi] PST - epublish SO - BMC Public Health. 2026 Mar 13;26(1):1303. doi: 10.1186/s12889-026-26951-y. PMID- 41825886 OWN - NLM STAT- MEDLINE DCOM- 20260618 LR - 20260818 IS - 1552-5732 (Electronic) IS - 0890-3344 (Linking) VI - 42 IP - 2 DP - 2026 May TI - Anxiety, Perceived Insufficient Milk, and Parenting Self-Efficacy in Mothers of Preterm Infants in Southeastern Turkey: A Cross-sectional Study. PG - 375-386 LID - 10.1177/08903344261419352 [doi] AB - BACKGROUND: Mothers of preterm infants often encounter challenges that include perceived insufficient milk supply, elevated state anxiety, and diminished maternal self-efficacy, all of which negatively influence breastfeeding practices and overall psychosocial wellbeing. While breastfeeding is known to enhance maternal confidence and reduce anxiety, these associations have also been examined in psychoeducational interventions addressing anxiety and self-efficacy during pregnancy. AIM: This study aimed to examine the associations between perception of insufficient milk supply, perceived maternal parenting self-efficacy, and state anxiety in mothers of preterm infants. METHODS: A cross-sectional study was conducted among 144 mothers of preterm infants attending pediatric outpatient clinic of a hospital in southeastern Turkey. Data were collected using validated instruments: the State Anxiety Inventory, the Perception of Insufficient Milk Supply Questionnaire, and the Perceived Maternal Parenting Self-Efficacy Scale. Statistical analyses included Spearman's rank correlation, generalized linear modeling, mediation analysis. RESULTS: Breastfeeding was the strongest predictor of lower perceptions of insufficient milk and higher perceived maternal parenting self-efficacy. State anxiety was positively associated with perceptions of insufficient milk and partially mediated the relationship between perceived milk insufficiency and perceived maternal parenting self-efficacy. CONCLUSION: The findings highlight the need for post-neonatal intensive care services that integrate lactation support with strategies aimed at reducing maternal anxiety to promote stronger parenting self-efficacy in mothers of preterm infants. FAU - Akca, Kamile AU - Akca K AUID- ORCID: 0000-0002-2833-8754 AD - Gaziantep Islam Science and Technology University, Faculty of Health Sciences, Gaziantep, Turkey. FAU - Butakin Ayhan, Derya AU - Butakin Ayhan D AUID- ORCID: 0000-0002-3333-9321 AD - Gaziantep Cengiz Gokcek Gynecology and Pediatrics Hospital, Pediatrics Department, Gaziantep, Turkey. FAU - Aytekin Ozdemir, Aynur AU - Aytekin Ozdemir A AUID- ORCID: 0000-0002-4738-0747 AD - Istanbul Medeniyet University, Faculty of Health Sciences, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20260313 PL - United States TA - J Hum Lact JT - Journal of human lactation : official journal of International Lactation Consultant Association JID - 8709498 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Turkey MH - *Self Efficacy MH - *Infant, Premature MH - Adult MH - Infant, Newborn MH - *Breast Feeding/psychology MH - *Anxiety/psychology/etiology MH - *Mothers/psychology MH - *Parenting/psychology MH - Surveys and Questionnaires MH - *Milk, Human MH - Young Adult OAB - Giris:Premature bebeklerin anneleri siklikla yetersiz sut algisi, durumluk kayginin artmasi ve anne oz yeterliliginin azalmasi gibi zorluklarla karsilasirlar; bu unsurlarin hepsi emzirme uygulamalarini ve genel psikososyal iyilik halini olumsuz etkiler. Emzirmenin anne ozguvenini artirdigi ve kaygiyi azalttigi bilinmekle birlikte, bu iliskiler gebelik sirasinda kaygi ve oz yeterlilik duygusunu ele alan psikoegitimsel mudahalelerde incelenmistir.Amac:Bu calisma, preterm bebek annelerinde yetersiz sut algisi, annenin algiladigi ebeveynlik oz yeterliligi ve durumluk kaygi arasindaki iliskileri incelemeyi amaclamistir.Yontem:Turkiye'nin guneydogusundaki bir hastanenin cocuk poliklinigine basvuran 144 premature bebek annesinde kesitsel bir calisma yurutulmustur. Veriler, gecerliligi kanitlanmis olcme araclari kullanilarak toplandi: Durumluk Kaygi Envanteri, Yetersiz Sut Algisi Olcegi ve Annenin Algiladigi Ebeveynlik Oz-Yeterligi Olcegi. Istatistiksel analizler; Spearman korelasyonu, genellestirilmis lineer modeli ve aracilik analizini icermektedir.Bulgular:Emzirme, yetersiz sut algisinin dusuk, annenin algiladigi ebeveynlik oz-yeterliligin yuksek olmasinin en guclu yordayicisi olmustur. Durumluk kaygi, yetersiz sut algisi ile pozitif yonde iliskili olup annenin algiladigi ebeveynlik oz-yeterliligi ile yetersiz sut algisi arasindaki iliskiye kismen aracilik etmistir.Sonuc:Bulgular, preterm bebeklerin annelerinde ebeveynlik oz-yeterligini guclendirmek icin anne kaygisini azaltmayi amaclayan stratejilerle emzirme desteginin entegre edildigi yenidogan yogun bakim sonrasi hizmetlere duyulan ihtiyaci vurgulamaktadir. OABL- eng OTO - NOTNLM OT - Turkey OT - Turkiye OT - anxiety OT - breastfeeding OT - emzirme OT - kaygi OT - maternal OT - milk OT - premature OT - premature OT - self-efficacy OT - sut OT - oz-yeterlik COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/03/14 00:31 MHDA- 2026/06/18 12:34 CRDT- 2026/03/13 20:53 PHST- 2026/06/18 12:34 [medline] PHST- 2026/03/14 00:31 [pubmed] PHST- 2026/03/13 20:53 [entrez] AID - 10.1177/08903344261419352 [doi] PST - ppublish SO - J Hum Lact. 2026 May;42(2):375-386. doi: 10.1177/08903344261419352. Epub 2026 Mar 13. PMID- 41825737 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260711 IS - 1541-6100 (Electronic) IS - 0022-3166 (Linking) VI - 156 IP - 5 DP - 2026 May TI - Artificial Intelligence-Assisted Dietary Assessment in Adolescent Girls in Sri Lanka: Validity against Weighed Food Records and Comparison with 24-Hour Recalls. PG - 101476 LID - S0022-3166(26)00125-2 [pii] LID - 10.1016/j.tjnut.2026.101476 [doi] AB - BACKGROUND: Reliable dietary data for adolescents in low- and middle-income countries (LMICs) are limited due to high costs and estimation errors in traditional dietary assessment methods. Although technology-assisted dietary assessment tools are becoming popular, few have been validated in LMICs. OBJECTIVES: This study validated the PlantVillage Food Recognition Assistance and Nudging Insights (FRANI), an artificial intelligence-assisted mobile application for dietary assessment, against weighed food records (WFR) and multipass 24-h recalls (24HR) among adolescent girls aged 14‒18 y (n = 60) in urban/semi-urban communities in Sri Lanka. METHODS: Dietary intake was assessed over 2 non-consecutive days using 3 methods: FRANI, WFR, and 24HR. The equivalence of nutrient intake was evaluated using mixed-effect models accounting for repeated measures by comparing intake ratios (FRANI/WFR and 24HR/WFR) with 10%, 15%, and 20% equivalence bounds. The concordance correlation coefficient was utilized to assess the agreement between methods. RESULTS: FRANI demonstrated equivalence with WFR at the 10% bound for energy and vitamin A; 15% for protein, fiber, iron, and zinc; and 20% for fat, niacin, and folate intakes. Comparisons between 24HR and WFR found that no nutrients fell within the 10% bound. Energy, protein, fat, iron, niacin, and vitamin A intakes were equivalent at 15% bound, whereas fiber, calcium, folate, and vitamin C intakes were equivalent at 20% bound. Concordance correlation coefficient ranged from 0.49 to 0.89 for FRANI compared to WFR, and 0.44 to 0.84 for 24HR compared with WFR. Omission errors were 2% for FRANI and 12% for 24HR, and intrusion errors were 7% and 9%, respectively. CONCLUSIONS: PlantVillage FRANI application accurately estimated nutrient intakes of adolescent girls in Sri Lanka compared to the WFR. Its performance was at least comparable to the traditional 24HR method, supporting its potential as a scalable alternative for dietary assessment in similar LMIC populations. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Karunarathna, Nilmini AU - Karunarathna N AD - Department of Nutrition and Dietetics, Faculty of Livestock, Fisheries and Nutrition, Wayamba University of Sri Lanka, Makandura, Gonawila, Sri Lanka. Electronic address: karunarathnahmnj@wyb.ac.lk. FAU - Perera, Thushanthi AU - Perera T AD - Department of Nutrition and Dietetics, Faculty of Livestock, Fisheries and Nutrition, Wayamba University of Sri Lanka, Makandura, Gonawila, Sri Lanka. FAU - Nwabuikwu, Odiche AU - Nwabuikwu O AD - International Food Policy Research Institute, Washington, DC, United States. FAU - Bannerman, Boateng AU - Bannerman B AD - Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana. FAU - Bempong, Silas AU - Bempong S AD - Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana. FAU - McCloskey, Peter AU - McCloskey P AD - Plant Village, Penn State University, State College, PA, United States. FAU - Nguyen, Phuong Hong AU - Nguyen PH AD - International Food Policy Research Institute, Washington, DC, United States; Thai Nguyen University of Pharmacy and Medicine, Thai Nguyen, Vietnam. FAU - Hughes, David AU - Hughes D AD - Plant Village, Penn State University, State College, PA, United States. FAU - Folson, Gloria AU - Folson G AD - Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana. FAU - Silva, Renuka AU - Silva R AD - Department of Nutrition and Dietetics, Faculty of Livestock, Fisheries and Nutrition, Wayamba University of Sri Lanka, Makandura, Gonawila, Sri Lanka. FAU - Gelli, Aulo AU - Gelli A AD - International Food Policy Research Institute, Washington, DC, United States. LA - eng PT - Comparative Study PT - Journal Article PT - Validation Study DEP - 20260312 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 SB - IM MH - Female MH - Sri Lanka MH - Humans MH - Adolescent MH - *Nutrition Assessment MH - *Diet Records MH - *Mental Recall MH - Reproducibility of Results MH - *Diet MH - Energy Intake OTO - NOTNLM OT - AI-assisted dietary assessment OT - Sri Lanka OT - adolescents OT - dietary assessment methods OT - validation COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/03/14 00:31 MHDA- 2026/05/09 00:34 CRDT- 2026/03/13 20:16 PHST- 2025/09/22 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2026/03/09 00:00 [accepted] PHST- 2026/05/09 00:34 [medline] PHST- 2026/03/14 00:31 [pubmed] PHST- 2026/03/13 20:16 [entrez] AID - S0022-3166(26)00125-2 [pii] AID - 10.1016/j.tjnut.2026.101476 [doi] PST - ppublish SO - J Nutr. 2026 May;156(5):101476. doi: 10.1016/j.tjnut.2026.101476. Epub 2026 Mar 12. PMID- 41825260 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 1873-5150 (Electronic) IS - 0887-8994 (Linking) VI - 178 DP - 2026 May TI - Electroencephalography-Based Machine Learning Models for Predicting Ketogenic Diet Outcomes in Pediatric Drug-Resistant Epilepsy. PG - 130-137 LID - S0887-8994(26)00057-3 [pii] LID - 10.1016/j.pediatrneurol.2026.02.013 [doi] AB - BACKGROUND: Ketogenic diet therapy (KDT) is an established treatment for drug-resistant epilepsy (DRE); however, methods for predicting its effectiveness remain underdeveloped. This study evaluated various machine learning (ML) models in predicting responses to KDT among DRE patients based on electroencephalography data. METHODS: Using leave-one-out cross-validation, this study evaluated 19 ML classifiers in predicting the outcomes of 90 DRE patients based on absolute and relative power, as well as functional connectivity measures (phase-locking value, phase lag index [PLI], and weighted PLI) across standard frequency bands. KDT significantly reduced seizure frequency at three and 6 months after initiation. RESULTS: The most effective classifier at 3 months was a Coarse Tree classifier trained on absolute power (recall = 0.933, precision = 0.767, F2 = 0.894, area under the receiver operating characteristic curve = 0.607). The most effective classifier at 6 months was a Gaussian Naive Bayes classifier trained on weighted PLI + relative power (recall = 0.759, precision = 0.854, F2 = 0.776, area under the receiver operating characteristic curve = 0.603). CONCLUSIONS: This study identified the most effective ML models for predicting KDT outcomes in DRE patients. The results highlight the potential of electroencephalography-based ML tools for guiding KDT treatment in clinical practice. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Hung, Pi-Lien AU - Hung PL AD - Division of Pediatric Neurology, Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rare Childhood Neurologic Disease Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. FAU - Chen, Jen-Ping AU - Chen JP AD - Department of Psychiatry, Beitou Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. FAU - Lin, Tzu-Ping AU - Lin TP AD - Department of Electrical Engineering, National Central University, Taoyuan, Taiwan. FAU - Hsieh, Tzu-Yun AU - Hsieh TY AD - Division of Pediatric Neurology, Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rare Childhood Neurologic Disease Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. FAU - Chen, Yi-Fen AU - Chen YF AD - Division of Pediatric Neurology, Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rare Childhood Neurologic Disease Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. FAU - Su, Ting-Yu AU - Su TY AD - Division of Pediatric Neurology, Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan; Rare Childhood Neurologic Disease Center, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, Taiwan. FAU - Peng, Syu-Jyun AU - Peng SJ AD - In-Service Master Program in Artificial Intelligence in Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; Clinical Big Data Research Center, Taipei Medical University Hospital, Taipei Medical University, Taipei, Taiwan. Electronic address: sjpeng2019@tmu.edu.tw. LA - eng PT - Journal Article DEP - 20260219 PL - United States TA - Pediatr Neurol JT - Pediatric neurology JID - 8508183 SB - IM MH - Humans MH - *Diet, Ketogenic MH - *Drug Resistant Epilepsy/diet therapy/physiopathology/diagnosis MH - *Electroencephalography/methods MH - Predictive Learning Models MH - Female MH - Child MH - Male MH - *Machine Learning MH - Child, Preschool MH - Adolescent MH - *Outcome Assessment, Health Care/methods MH - Classification Algorithms MH - Treatment Outcome MH - Prediction Algorithms OTO - NOTNLM OT - Drug-resistant epilepsy OT - EEG power spectrum OT - Functional connectivity OT - Ketogenic diet therapy OT - Machine learning OT - Outcome prediction COIS- Declaration of competing interest This work was financially supported in part by the National Science and Technology Council, Taiwan, under the project NSTC 112-2628-E-038-001-MY3 and NSTC 114-2622-E-038-001. EDAT- 2026/03/14 00:31 MHDA- 2026/04/23 00:31 CRDT- 2026/03/13 19:09 PHST- 2025/10/29 00:00 [received] PHST- 2026/01/22 00:00 [revised] PHST- 2026/02/16 00:00 [accepted] PHST- 2026/04/23 00:31 [medline] PHST- 2026/03/14 00:31 [pubmed] PHST- 2026/03/13 19:09 [entrez] AID - S0887-8994(26)00057-3 [pii] AID - 10.1016/j.pediatrneurol.2026.02.013 [doi] PST - ppublish SO - Pediatr Neurol. 2026 May;178:130-137. doi: 10.1016/j.pediatrneurol.2026.02.013. Epub 2026 Feb 19. PMID- 41824634 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260313 LR - 20260813 IS - 2291-9279 (Print) IS - 2291-9279 (Electronic) VI - 14 DP - 2026 Mar 13 TI - Development of a Novel Dietary Assessment Method Using Gamification Concepts: Exploratory and Application Study. PG - e72387 LID - 10.2196/72387 [doi] LID - e72387 AB - BACKGROUND: Childhood and adolescent malnutrition, encompassing undernutrition and overnutrition, poses significant global health challenges, necessitating comprehensive dietary assessment tools. Existing dietary assessment methods, such as 24-hour dietary recalls (24HR), often fail to capture eating behaviors and food preferences. OBJECTIVE: This study aims to compare a newly developed gamified dietary assessment tool (GDA) with a traditional 24HR and to explore its applicability in assessing dietary behavior tendencies among children and adolescents. METHODS: A 2-phase study was designed, including an exploratory and an application study. The exploratory study included 30 school-aged participants, comparing the GDA with the 3-day 24HR. Nutrient and food intakes were analyzed using Pearson or Spearman correlation coefficients and Bland-Altman plots. The application study, conducted among 1541 adolescents (11-18 y), assessed dietary intake and eating behavior tendencies. Differences in dietary intake across age, gender, socioeconomic status, and weight status were analyzed using the Kruskal-Wallis rank sum test. Multiple linear regression models were used to examine the associations of dietary intakes with emotional eating and with dining environment tendencies, respectively. RESULTS: In the exploratory study (n=30), the GDA demonstrated moderate agreement with 24HR for energy (r=0.46, P=.01) and carbohydrates (r=0.50, P=.005). Bland-Altman plots indicated good agreement for energy and carbohydrate intake between methods (mean differences around 0). For fat intake, although the mean difference was close to 0, the correlation was not statistically significant. In contrast, the GDA substantially overestimated protein intake (mean difference around 25 g). In the application study (n=1541), higher emotional eating scores were associated with higher snack consumption (beta=0.438, 95% CI 0.035-0.840), and with lower protein (beta=-0.159, 95% CI -0.267 to -0.052), fruit (beta=-0.464, 95% CI -0.854 to -0.073), and nut consumption (beta=-0.183, 95% CI -0.304 to -0.062). Participants who chose solitary screen eating consumed significantly more carbohydrates than those who selected "eat with peers" (beta=4.2, 95% CI 1.2-7.1). CONCLUSIONS: This study demonstrates that the GDA effectively captures both dietary intake and contextual eating behaviors in young populations, providing data distinct from traditional methods, such as 24HR. As a complementary assessment approach, it offers valuable insights into food preferences and eating patterns through its interactive design. CI - (c) Yulin Zhang, Tianwu Lin, Yuefeng Tan, Xiaojin Shi, Yucheng Yang, Haibing Yang, Xiaona Na, Junhan Zhang, Ai Zhao. Originally published in JMIR Serious Games (https://games.jmir.org). FAU - Zhang, Yulin AU - Zhang Y AUID- ORCID: 0000-0002-3259-9498 AD - Vanke School of Public Health, Tsinghua University, Jinchunyuan Building, Tsinghua University, 30th Shuang Qing Road, Hadian District, Beijing, 100084, China, 86 13811131994. FAU - Lin, Tianwu AU - Lin T AUID- ORCID: 0009-0009-7509-8536 AD - Shenzhen Yantian Maternal and Child Health Hospital, Shenzhen, Guangdong, China. FAU - Tan, Yuefeng AU - Tan Y AUID- ORCID: 0009-0003-3294-9122 AD - Vanke School of Public Health, Tsinghua University, Jinchunyuan Building, Tsinghua University, 30th Shuang Qing Road, Hadian District, Beijing, 100084, China, 86 13811131994. FAU - Shi, Xiaojin AU - Shi X AUID- ORCID: 0000-0002-1738-2856 AD - Vanke School of Public Health, Tsinghua University, Jinchunyuan Building, Tsinghua University, 30th Shuang Qing Road, Hadian District, Beijing, 100084, China, 86 13811131994. FAU - Yang, Yucheng AU - Yang Y AUID- ORCID: 0000-0003-4402-631X AD - Vanke School of Public Health, Tsinghua University, Jinchunyuan Building, Tsinghua University, 30th Shuang Qing Road, Hadian District, Beijing, 100084, China, 86 13811131994. FAU - Yang, Haibing AU - Yang H AUID- ORCID: 0009-0008-2141-505X AD - Vanke School of Public Health, Tsinghua University, Jinchunyuan Building, Tsinghua University, 30th Shuang Qing Road, Hadian District, Beijing, 100084, China, 86 13811131994. FAU - Na, Xiaona AU - Na X AUID- ORCID: 0000-0002-0107-252X AD - Vanke School of Public Health, Tsinghua University, Jinchunyuan Building, Tsinghua University, 30th Shuang Qing Road, Hadian District, Beijing, 100084, China, 86 13811131994. FAU - Zhang, Junhan AU - Zhang J AUID- ORCID: 0000-0001-5293-1198 AD - Vanke School of Public Health, Tsinghua University, Jinchunyuan Building, Tsinghua University, 30th Shuang Qing Road, Hadian District, Beijing, 100084, China, 86 13811131994. FAU - Zhao, Ai AU - Zhao A AUID- ORCID: 0000-0002-1679-973X AD - Vanke School of Public Health, Tsinghua University, Jinchunyuan Building, Tsinghua University, 30th Shuang Qing Road, Hadian District, Beijing, 100084, China, 86 13811131994. LA - eng PT - Journal Article DEP - 20260313 PL - Canada TA - JMIR Serious Games JT - JMIR serious games JID - 101645255 PMC - PMC12987409 OTO - NOTNLM OT - dietary assessment OT - dietary intake OT - eating behavior tendencies OT - food preference OT - gamification COIS- Conflicts of Interest: None declared. EDAT- 2026/03/13 19:31 MHDA- 2026/03/13 19:32 PMCR- 2026/03/13 CRDT- 2026/03/13 14:23 PHST- 2025/02/26 00:00 [received] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/03/13 19:32 [medline] PHST- 2026/03/13 19:31 [pubmed] PHST- 2026/03/13 14:23 [entrez] PHST- 2026/03/13 00:00 [pmc-release] AID - v14i1e72387 [pii] AID - 72387 [pii] AID - 10.2196/72387 [doi] PST - epublish SO - JMIR Serious Games. 2026 Mar 13;14:e72387. doi: 10.2196/72387. PMID- 41824507 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 3 DP - 2026 TI - Protocol for a cluster-randomized control trial of a remote workplace resilience intervention for early care and education providers: The OnWARD trial. PG - e0340915 LID - 10.1371/journal.pone.0340915 [doi] LID - e0340915 AB - Work-related stressors take a toll on individuals' health and well-being, a toll which is often heavier for under-resourced, low-paid segments of the essential workforce who serve our communities. Resilience programs have arisen as a promising workplace strategy to improve mental health and well-being. However, emerging programs are constrained by time and resource-intensive implementation strategies that are challenging to scale for marginalized segments of the workforce, including early childcare education (ECE) staff. The goal of this 15-month cluster randomized control trial is to compare change in resilience assets and resources for ECE staff in centers (n = 80 consisting of 640 ECE workers) randomly assigned to either a remotely delivered resilience (intervention) or physical activity (attention control) program. Measures will be collected at four timepoints: baseline (0 months), post-intervention (3 months), and long-term maintenance (9 and 15 months). Secondary outcomes will include changes in well-being, physical activity, organizational support, absenteeism, and turnover. Additionally, we will explore potential moderators of the treatment effects. The RE-AIM Framework will be used to determine the potential for individual (staff) and organizational (center) level reach, adoption, implementation, and maintenance of the two programs. Results will fill key gaps of prior resilience work by focusing on an underserved population in critical need of well-being resources with implications for the feasibility and impact of remote programming in other segments of the workforce. Trial Registration: This trial is registered with the ClinicalTrials.gov registry (NCT06919952) and approved by the Institutional Review Board (IRB) at the University of North Carolina at Chapel Hill (IRB# 25-0016). CI - Copyright: (c) 2026 Hales et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Hales, Derek AU - Hales D AUID- ORCID: 0000-0001-5014-3892 AD - Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. FAU - Burney, Regan AU - Burney R AD - Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. FAU - Willis, Erik AU - Willis E AUID- ORCID: 0000-0002-0114-1660 AD - Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. FAU - Clarke, Emmy AU - Clarke E AD - Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. FAU - Peterson, Sarah AU - Peterson S AUID- ORCID: 0009-0003-8753-7934 AD - Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. FAU - Branch, Shakiera AU - Branch S AD - Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. FAU - Fowlin, Brandon AU - Fowlin B AD - Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. FAU - Chesak, Sherry AU - Chesak S AD - Center for Flourishing Health Care Communities, University of Minnesota, School of Nursing, Minneapolis, Minnesota, United State of America. FAU - Linnan, Lara A AU - Linnan LA AD - Department of Health Behavior, UNC Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. FAU - Sood, Amit AU - Sood A AD - Sutardja Center for Entrepreneurship & Technology, U.C. Berkeley, Berkeley, California, United States of America. FAU - Suazo, Nazaret C AU - Suazo NC AD - Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. FAU - Jones, Deborah J AU - Jones DJ AD - Center for Health Promotion and Disease Prevention, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. AD - Department of Psychology and Neuroscience, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America. LA - eng SI - ClinicalTrials.gov/NCT06919952 GR - R01 AT012620/AT/NCCIH NIH HHS/United States PT - Clinical Trial Protocol PT - Journal Article DEP - 20260313 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM EIN - PLoS One. 2026 Apr 21;21(4):e0347833. doi: 10.1371/journal.pone.0347833. PMID: 42013037 MH - Humans MH - *Resilience, Psychological MH - *Workplace/psychology MH - Randomized Controlled Trials as Topic PMC - PMC12987477 COIS- I have read the journal's policy and the authors of this manuscript have the following competing interests: Dr. Chesak is a co-investigator on this project and serves as a research advisor for the SMART program. She advises Dr. Sood regarding the use, implementation, and integration of the SMART program in research. Dr. Sood serves as a consultant on this project and is the developer and owner of the SMART program. He provides training for the study interventionist and supports the use and integration of the SMART program into this intervention. Dr. Sood will not participate in recruitment, data collection, analysis, or interpretation of the results. EDAT- 2026/03/13 19:31 MHDA- 2026/03/13 19:32 PMCR- 2026/03/13 CRDT- 2026/03/13 13:43 PHST- 2025/12/10 00:00 [received] PHST- 2025/12/15 00:00 [accepted] PHST- 2026/03/13 19:32 [medline] PHST- 2026/03/13 19:31 [pubmed] PHST- 2026/03/13 13:43 [entrez] PHST- 2026/03/13 00:00 [pmc-release] AID - PONE-D-25-55962 [pii] AID - 10.1371/journal.pone.0340915 [doi] PST - epublish SO - PLoS One. 2026 Mar 13;21(3):e0340915. doi: 10.1371/journal.pone.0340915. eCollection 2026. PMID- 41823958 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260831 IS - 2689-0186 (Electronic) IS - 2689-0186 (Linking) VI - 7 IP - 3 DP - 2026 Mar 6 TI - Instability of Global Burden of Disease Estimates of Deaths and Disability-Adjusted Life-Years From Major Risk Factors: A Meta-Epidemiological Analysis. PG - e260108 LID - 10.1001/jamahealthforum.2026.0108 [doi] LID - e260108 AB - IMPORTANCE: The Global Burden of Disease (GBD) reports widely used estimates of mortality and disability-adjusted life-years (DALYs) and related risk factors. However, the overall reliability of these estimates between GBD iterations has not been assessed. OBJECTIVE: To evaluate the instability and inconsistency of GBD risk factor estimates for mortality and DALYs across GBD iterations. DATA SOURCES: GBD risk factor collaboration estimates extracted from the published tables of GBD iterations and the Institute for Health Metrics and Evaluation repository. STUDY SELECTION: GBD risk factor collaboration publications published for 2010 through 2023. DATA EXTRACTION AND SYNTHESIS: Death and DALY estimates were manually extracted by 1 reviewer with independent validation of a random sample of 100 by another with no discrepancies. Risk factor naming was harmonized across iterations to ensure comparability; those with inconsistent definitions were excluded. MAIN OUTCOMES AND MEASURES: Fluctuations were calculated for numbers of deaths and DALYs for each risk factor across GBD iterations during the study period (2010-2023) and between the original and subsequently revised estimates for each year (1990-2021). Differences were expressed as a ratio of the minimum to maximum range to the mean (R:M) and coefficient of variation. Detail analyses assessed diet and low physical activity. Point estimates were compared to the previous iterations' estimates 95% uncertainty intervals (95% UI) for GBD 2019, 2021, and 2023. RESULTS: Across GBD iterations from 2010 to 2023, the median (range) R:M was 0.8 (0-3.8) for deaths, and 0.7 (0.1-3.3) for DALYs. Level 2 dietary and child and maternal malnutrition death estimates showed high instability (R:M >1 for 9 of 16 and 4 of 8 risks, respectively). When comparing original estimates with GBD 2019, 2021, and 2023 estimates for the same years, the median R:M was 0.4 (0-2.9) for both deaths and DALYs. The coefficient of variation was greater than 0.2 for 336 of 675 death estimates (50%). Specifically, 70% to 96% of point estimates for red meat, sugar-sweetened beverages, fruits, vegetables, and seafood omega-3 fatty acids in GBD 2021 fell outside the GBD 2019 95% UI. In GBD 2023, only diet high in trans fats had more than half of point estimates outside the GBD 2021 95% UI. CONCLUSIONS AND RELEVANCE: This meta-epidemiological assessment indicates that GBD estimates are substantially unstable, particularly for behavioral risks, making them unlikely to simply reflect genuine changes over time, and warranting caution in interpretation. FAU - Zavalis, Emmanuel A AU - Zavalis EA AD - Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. AD - Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden. AD - Meta-Research Innovation Center at Stanford, Stanford University, Stanford, California. FAU - Pezzullo, Angelo Maria AU - Pezzullo AM AD - Meta-Research Innovation Center at Stanford, Stanford University, Stanford, California. AD - Section of Hygiene, Department of Life Sciences and Public Health, Universita Cattolica del Sacro Cuore, Rome, Italy. FAU - Ioannidis, John P A AU - Ioannidis JPA AD - Meta-Research Innovation Center at Stanford, Stanford University, Stanford, California. AD - Department of Medicine, Stanford University, Stanford, California. AD - Department of Epidemiology and Population Health, Stanford University, Stanford, California. AD - Department of Biomedical Data Science, Stanford University, Stanford, California. LA - eng PT - Journal Article PT - Meta-Analysis DEP - 20260306 PL - United States TA - JAMA Health Forum JT - JAMA health forum JID - 101769500 SB - IM MH - Humans MH - *Global Burden of Disease/trends MH - Risk Factors MH - *Disability-Adjusted Life Years MH - *Mortality/trends PMC - PMC12988449 COIS- Conflict of Interest Disclosures: Dr Pezzullo reported membership in the Global Burden of Disease Collaborator Network (nonfinancial relationship). No other disclosures were reported. EDAT- 2026/03/13 12:41 MHDA- 2026/03/13 12:42 PMCR- 2026/03/13 CRDT- 2026/03/13 11:33 PHST- 2026/03/13 12:42 [medline] PHST- 2026/03/13 12:41 [pubmed] PHST- 2026/03/13 11:33 [entrez] PHST- 2026/03/13 00:00 [pmc-release] AID - 2845973 [pii] AID - aoi260003 [pii] AID - 10.1001/jamahealthforum.2026.0108 [doi] PST - epublish SO - JAMA Health Forum. 2026 Mar 6;7(3):e260108. doi: 10.1001/jamahealthforum.2026.0108. PMID- 41823935 OWN - NLM STAT- MEDLINE DCOM- 20260610 LR - 20260610 IS - 1878-2620 (Electronic) IS - 1499-4046 (Linking) VI - 58 IP - 6 DP - 2026 Jun TI - Valid and Reliable Questionnaire for Assessing Nutrition and Physical Activity Practices in Early Care and Education. PG - 556-565 LID - S1499-4046(26)00035-7 [pii] LID - 10.1016/j.jneb.2026.01.020 [doi] AB - OBJECTIVE: Valid, reliable, and comprehensive instruments enable early care and education (ECE) sites to self-assess nutrition and physical activity practices and policies, but availability is limited. Therefore, we developed and assessed the test-retest reliability and convergent validity of the Site-Level Assessment Questionnaire (SLAQ). DESIGN: Reliability testing compared questionnaires completed by ECE personnel at 2 time points (reliability pairs). Convergent validity testing compared questionnaires completed by ECE personnel with questionnaires completed by researchers (validity pairs). Semistructured interviews with personnel who completed the SLAQ informed revisions. SETTING: California Supplemental Nutrition Assistance Program Education-eligible ECE sites. PARTICIPANTS: Convenience sample of 32 ECE sites (18 school districts; 14 Head Starts). VARIABLES MEASURED: Seventy-six items assessing wellness policies, federal food program participation, meals, snacks, beverages, food environment, feeding practices, nutrition education, gardens, physical activity, screen time, family involvement, and breastfeeding support. ANALYSIS: Weighted kappa test statistics and percent agreement were calculated for each item to assess agreement between reliability pairs and validity pairs. RESULTS: Eighty-eight percent of items showed moderate or higher reliability; 52% had moderate or higher validity. On the basis of these results and interview findings, the SLAQ was revised to address issues identified. CONCLUSIONS AND IMPLICATIONS: Findings suggest acceptable validity and reliability of the SLAQ for assessing policies and practices at SNAP-Ed-eligible ECE sites in California. Further testing with larger, randomly selected, and geographically and socioeconomically diverse populations could broaden its application. As is, the comprehensive assessment data the SLAQ provides can be used to identify opportunities for improving ECE practices and policies that support children's health. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Becker, Christina M AU - Becker CM AD - Nutrition Policy Institute, University of California, Division of Agriculture and Natural Resources, Oakland, CA. FAU - Kao, Janice AU - Kao J AD - Nutrition Policy Institute, University of California, Division of Agriculture and Natural Resources, Oakland, CA. Electronic address: jankao@ucanr.edu. FAU - Hewawitharana, Sridharshi C AU - Hewawitharana SC AD - Nutrition Policy Institute, University of California, Division of Agriculture and Natural Resources, Oakland, CA. FAU - Rider, Carolyn D AU - Rider CD AD - Nutrition Policy Institute, University of California, Division of Agriculture and Natural Resources, Oakland, CA. FAU - Linares, Amanda AU - Linares A AD - Nutrition Policy Institute, University of California, Division of Agriculture and Natural Resources, Oakland, CA. FAU - Strochlic, Ron AU - Strochlic R AD - Nutrition Policy Institute, University of California, Division of Agriculture and Natural Resources, Oakland, CA. FAU - Brown, Miranda Westfall AU - Brown MW AD - Nutrition Policy Institute, University of California, Division of Agriculture and Natural Resources, Oakland, CA. FAU - Woodward-Lopez, Gail AU - Woodward-Lopez G AD - Nutrition Policy Institute, University of California, Division of Agriculture and Natural Resources, Oakland, CA. LA - eng PT - Journal Article PT - Validation Study DEP - 20260313 PL - United States TA - J Nutr Educ Behav JT - Journal of nutrition education and behavior JID - 101132622 SB - IM MH - Humans MH - Surveys and Questionnaires/standards MH - *Exercise MH - California MH - Reproducibility of Results MH - Child, Preschool MH - Food Assistance MH - Female OTO - NOTNLM OT - SNAP-Ed OT - early care and education OT - health promotion OT - needs assessment OT - surveys and questionnaires COIS- CONFLICT OF INTEREST DISCLOSURE The authors have not stated any conflicts of interest. EDAT- 2026/03/13 12:40 MHDA- 2026/06/11 05:41 CRDT- 2026/03/13 11:28 PHST- 2024/03/27 00:00 [received] PHST- 2026/01/12 00:00 [revised] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/06/11 05:41 [medline] PHST- 2026/03/13 12:40 [pubmed] PHST- 2026/03/13 11:28 [entrez] AID - S1499-4046(26)00035-7 [pii] AID - 10.1016/j.jneb.2026.01.020 [doi] PST - ppublish SO - J Nutr Educ Behav. 2026 Jun;58(6):556-565. doi: 10.1016/j.jneb.2026.01.020. Epub 2026 Mar 13. PMID- 41823339 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261023 IS - 1934-1563 (Electronic) IS - 1934-1482 (Print) IS - 1934-1482 (Linking) VI - 18 IP - 10 DP - 2026 Oct TI - Core stability in women with and without chronic pelvic pain. PG - 1184-1193 LID - 10.1002/pmrj.70103 [doi] AB - BACKGROUND: Physical activity (PA) and core stability levels are unknown for women with musculoskeletal chronic pelvic pain (CPP) compared to healthy women. At this time, there is no validated treatment method aimed specifically at CPP. OBJECTIVE: To elucidate the PA habits and core stability of women with and without CPP. We hypothesized that aerobic and resistance PA (aPA, rPA) and core stability would differ significantly. DESIGN: Prospective, cross-sectional study. Wilcoxon rank sum tests, simple and multiple linear regressions, and Pearson chi-square test were used for analysis. SETTING: Primary and specialty care outpatient physical medicine and rehabilitation, female pelvic medicine and reconstructive surgery, and gynecology clinics associated with a large tertiary center. PATIENTS: We recruited 91 women aged 18-70 years with and without CPP (defined by American College of Obstetricians and Gynecologists). INTERVENTIONS: Not applicable. MAIN OUTCOME MEASURES: Physical activity, core stability scores. RESULTS: Women with CPP demonstrated lower overall core stability (p = .04). Having CPP predicted a 2-point decrease in overall core score (p < .01). Women with CPP demonstrated significantly worse scores for the supine bridge (p < .01) and prone bridge (p = .03). There were no significant differences in aPA or rPA between women with and without CPP. Pelvic floor muscle strength did not have a significant effect on core scores in women with CPP before or after adjusting for age, parity, and body mass index. CONCLUSIONS: This study reports a novel finding that women with CPP had significantly reduced core scores (suggestive of weaker core stability) but similar levels of physical activity (aPA and rPA) compared to women without CPP. Future directions will include larger, multicenter, randomized controlled trials to investigate the association between pelvic floor muscles and core stability as well as therapeutic interventions to include specific exercises targeted at improving overall core stability in women with CPP. CI - (c) 2026 The Author(s). PM&R published by Wiley Periodicals LLC on behalf of American Academy of Physical Medicine and Rehabilitation. FAU - Chatwin, Hannah V AU - Chatwin HV AUID- ORCID: 0000-0001-8328-0869 AD - Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA. FAU - Kumar, Abhilasha AU - Kumar A AD - Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA. FAU - Wesolowski, Michael AU - Wesolowski M AD - Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA. FAU - Glaser, Laura AU - Glaser L AD - Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA. FAU - Fitzgerald, Colleen M AU - Fitzgerald CM AD - Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA. FAU - Bennis, Stacey AU - Bennis S AD - Loyola University Chicago Stritch School of Medicine, Maywood, Illinois, USA. LA - eng PT - Journal Article DEP - 20260313 PL - United States TA - PM R JT - PM & R : the journal of injury, function, and rehabilitation JID - 101491319 SB - IM MH - Humans MH - Female MH - Adult MH - Middle Aged MH - Cross-Sectional Studies MH - *Pelvic Pain/physiopathology/rehabilitation MH - Prospective Studies MH - *Chronic Pain/physiopathology/rehabilitation MH - Aged MH - Young Adult MH - Adolescent MH - Pelvic Floor/physiopathology MH - Pain Measurement MH - *Exercise/physiology MH - Muscle Strength/physiology PMC - PMC13686104 COIS- None of the authors have a conflict of interest to disclose. EDAT- 2026/03/13 12:41 MHDA- 2026/10/22 23:28 PMCR- 2026/10/21 CRDT- 2026/03/13 08:33 PHST- 2025/12/15 00:00 [revised] PHST- 2024/12/16 00:00 [received] PHST- 2026/01/08 00:00 [accepted] PHST- 2026/10/22 23:28 [medline] PHST- 2026/03/13 12:41 [pubmed] PHST- 2026/03/13 08:33 [entrez] PHST- 2026/10/21 00:00 [pmc-release] AID - PMRJ70103 [pii] AID - 10.1002/pmrj.70103 [doi] PST - ppublish SO - PM R. 2026 Oct;18(10):1184-1193. doi: 10.1002/pmrj.70103. Epub 2026 Mar 13. PMID- 41823283 OWN - NLM STAT- MEDLINE DCOM- 20260929 LR - 20261022 IS - 1461-7021 (Electronic) IS - 1359-1045 (Print) IS - 1359-1045 (Linking) VI - 31 IP - 4 DP - 2026 Oct TI - Concurrent Validity of the CBCL DSM-Oriented Scales: Evidence from the ABCD Study. PG - 1890-1909 LID - 10.1177/13591045261431338 [doi] AB - ObjectivePrevious research has yielded mixed findings regarding the validity of the Child Behavior Checklist (CBCL) DSM-Oriented Scales (DOSs) in identifying DSM diagnoses. The present study evaluates the concurrent validity of the DOSs by comparing scale classifications with a gold-standard clinical interview.MethodsParticipants (N = 11,851) were children in the NIH Adolescent Brain Cognitive Development (ABCD) study whose caregivers completed the CBCL and the Kiddie Schedule for Affective Disorders and Schizophrenia (KSADS) semi-structured interview at baseline (9.92 years, SD = 0.63), two-year follow-up (12.03 years, SD = 0.67), or both.Results2,321 (19.59%) children at baseline and 1,708 (15.57%) participants at two-year follow-up met criteria for one or more KSADS disorders. Sensitivity of the CBCL relative to KSADS diagnoses was generally low (10.36% - 75.00%), with only two scales above 50%. Specificity was high (92.47% - 97.07%). Positive predictive values were low (0.71% - 48.20%), and negative predictive values were high (89.84% - 99.90%). Area under the curve (AUC) ranged from 0.55 to 0.84.DiscussionIn the present sample, the DOSs showed poor concurrent validity with a gold standard clinical interview. Caution should be exercised when using the CBCL due to the high rates of false negatives. FAU - Chromik, Lindsay C AU - Chromik LC AUID- ORCID: 0000-0001-8585-4088 AD - Department of Psychology, REACH Institute, Arizona State University, Tempe, AZ, USA. RINGGOLD: 7864 FAU - Friedman, Lauren M AU - Friedman LM AUID- ORCID: 0000-0002-3903-5695 AD - Department of Psychology, REACH Institute, Arizona State University, Tempe, AZ, USA. RINGGOLD: 7864 LA - eng GR - U24 DA041147/DA/NIDA NIH HHS/United States GR - U01 DA051039/DA/NIDA NIH HHS/United States GR - U01 DA041120/DA/NIDA NIH HHS/United States GR - K23 MH128536/MH/NIMH NIH HHS/United States GR - U01 DA051018/DA/NIDA NIH HHS/United States GR - U01 DA041093/DA/NIDA NIH HHS/United States GR - U24 DA041123/DA/NIDA NIH HHS/United States GR - U01 DA051038/DA/NIDA NIH HHS/United States GR - U01 DA051037/DA/NIDA NIH HHS/United States GR - U01 DA051016/DA/NIDA NIH HHS/United States GR - U01 DA041106/DA/NIDA NIH HHS/United States GR - U01 DA041117/DA/NIDA NIH HHS/United States GR - U01 DA041148/DA/NIDA NIH HHS/United States GR - U01 DA041174/DA/NIDA NIH HHS/United States GR - U01 DA041134/DA/NIDA NIH HHS/United States GR - U01 DA041022/DA/NIDA NIH HHS/United States GR - U01 DA041156/DA/NIDA NIH HHS/United States GR - U01 DA050987/DA/NIDA NIH HHS/United States GR - U01 DA041025/DA/NIDA NIH HHS/United States GR - U01 DA050989/DA/NIDA NIH HHS/United States GR - U01 DA041089/DA/NIDA NIH HHS/United States GR - U01 DA050988/DA/NIDA NIH HHS/United States GR - U01 DA041028/DA/NIDA NIH HHS/United States GR - U01 DA041048/DA/NIDA NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20260313 PL - England TA - Clin Child Psychol Psychiatry JT - Clinical child psychology and psychiatry JID - 9604507 SB - IM MH - Humans MH - Female MH - Child MH - *Diagnostic and Statistical Manual of Mental Disorders MH - Male MH - Reproducibility of Results MH - *Psychiatric Status Rating Scales/standards MH - *Mental Disorders/diagnosis MH - Sensitivity and Specificity MH - Adolescent MH - Psychometrics MH - *Child Behavior MH - Follow-Up Studies PMC - PMC13679724 MID - NIHMS2215665 OAB - The Child Behavior Checklist is a commonly used questionnaire for caregivers to rate symptoms of mental health conditions in children. Previous research shows conflicting support for the accuracy of the questionnaire results. This study examined how well scores on the questionnaire matched diagnoses based on a gold-standard diagnostic interview. Results showed the questionnaire identified fewer children with mental health concerns than the diagnostic interview. Given that the CBCL under identified children with mental health concerns, this study urges caution when using the questionnaire as part of a diagnostic evaluation. OABL- eng OTO - NOTNLM OT - ABCD study OT - CBCL OT - child and adolescent psychopathology OT - concurrent validity OT - psychometrics COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/03/13 12:41 MHDA- 2026/09/29 12:26 PMCR- 2026/10/19 CRDT- 2026/03/13 08:03 PHST- 2026/09/29 12:26 [medline] PHST- 2026/03/13 12:41 [pubmed] PHST- 2026/03/13 08:03 [entrez] PHST- 2026/10/19 00:00 [pmc-release] AID - 10.1177/13591045261431338 [doi] PST - ppublish SO - Clin Child Psychol Psychiatry. 2026 Oct;31(4):1890-1909. doi: 10.1177/13591045261431338. Epub 2026 Mar 13. PMID- 41823249 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261010 IS - 1545-1569 (Electronic) IS - 1055-6656 (Print) IS - 1055-6656 (Linking) VI - 63 IP - 11 DP - 2026 Nov TI - What We Learnt in Unilateral Cleft Lip Repair Between Millard's and Tennison-Randall's Techniques: Comparison of the Outcomes in Adult Patients. PG - 3699-3706 LID - 10.1177/10556656261422855 [doi] AB - ObjectiveTo compare long-term esthetic and morphological outcomes of unilateral cleft lip (UCL) repair using the Millard rotation-advancement versus the Tennison-Randall triangular flap technique, testing whether Millard provides superior lip symmetry.DesignRetrospective cohort study.SettingSingle tertiary cleft center.Patients, ParticipantsForty adults aged 18-25 were selected from 168 patients treated between 1988 and 1995. Inclusion criteria: complete UCL, primary cheiloplasty, absence of secondary lip revisions, complete frontal photographic documentation, and no syndromic diagnoses. Twenty underwent Millard repair and twenty Tennison-Randall repair.InterventionsPrimary UCL reconstruction performed using either Millard rotation-advancement or Tennison-Randall triangular flap. All operations were carried out by the same senior cleft surgeon under comparable operative conditions.Main Outcome Measure(s)Long-term lip symmetry quantified through a Symmetry Index derived from predefined anthropometric landmarks on standardized images. Subjective esthetic satisfaction assessed using the esthetic Units Satisfaction Questionnaire and the Cleft esthetic Rating Scale, completed by patients, the operating surgeon, and a blinded observer.ResultsMillard repair showed significantly greater medial lip width symmetry (p = .014). No significant differences were found for vermilion height, prolabial height, lateral lip width, or lip area. Subjective assessments consistently favored Millard, showing higher satisfaction and fewer negative ratings. Inter-rater reliability across evaluators was high (ICC = 0.82).ConclusionsBoth techniques produced stable long-term outcomes, but Millard yielded superior medial lip symmetry and higher esthetic satisfaction. These findings support its continued clinical preference and highlight the importance of long-term evaluations. Larger prospective studies are needed to confirm these results. FAU - Pistoia, Angelica AU - Pistoia A AUID- ORCID: 0009-0004-8009-0209 AD - Plastic and Maxillofacial Surgery Unit, Cleft and Craniofacial Center, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. RINGGOLD: 9342 AD - Plastic Surgery Unit, School of Medicine and Surgery, Tor Vergata University of Rome, Rome, Italy. FAU - Rizzo, Maria Ida AU - Rizzo MI AD - Plastic and Maxillofacial Surgery Unit, Cleft and Craniofacial Center, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. RINGGOLD: 9342 FAU - Grippaudo, Francesca R AU - Grippaudo FR AD - Plastic Surgery Unit, Faculty of Medicine and Psychology, Sapienza University of Rome, Rome, Italy. RINGGOLD: 60218 FAU - Cajozzo, Marta AU - Cajozzo M AD - Plastic and Maxillofacial Surgery Unit, Cleft and Craniofacial Center, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. RINGGOLD: 9342 FAU - Grussu, Francesca AU - Grussu F AD - Plastic and Maxillofacial Surgery Unit, Cleft and Craniofacial Center, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. RINGGOLD: 9342 FAU - Molinaro, Francesco AU - Molinaro F AD - Division of Pediatric Surgery, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy. RINGGOLD: 9313 FAU - Nascimben, Francesca AU - Nascimben F AD - Plastic and Maxillofacial Surgery Unit, Cleft and Craniofacial Center, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. RINGGOLD: 9342 AD - Division of Pediatric Surgery, Department of Medical, Surgical and Neurological Sciences, University of Siena, Siena, Italy. RINGGOLD: 9313 FAU - Zama, Mario AU - Zama M AD - Plastic and Maxillofacial Surgery Unit, Cleft and Craniofacial Center, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. RINGGOLD: 9342 LA - eng PT - Comparative Study PT - Journal Article DEP - 20260313 PL - United States TA - Cleft Palate Craniofac J JT - The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association JID - 9102566 SB - IM MH - Humans MH - *Cleft Lip/surgery MH - Adult MH - *Surgical Flaps MH - *Plastic Surgery Procedures/methods MH - Treatment Outcome MH - Patient Satisfaction MH - Female MH - Male MH - Adolescent MH - Esthetics MH - Young Adult MH - Cohort Studies MH - Surveys and Questionnaires PMC - PMC13646428 OTO - NOTNLM OT - Millard technique OT - Tennison-Randall technique OT - cheiloplasty OT - unilateral cleft lip COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/03/13 12:40 MHDA- 2026/10/07 17:33 PMCR- 2026/10/08 CRDT- 2026/03/13 07:44 PHST- 2026/10/07 17:33 [medline] PHST- 2026/03/13 12:40 [pubmed] PHST- 2026/03/13 07:44 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - 10.1177_10556656261422855 [pii] AID - 10.1177/10556656261422855 [doi] PST - ppublish SO - Cleft Palate Craniofac J. 2026 Nov;63(11):3699-3706. doi: 10.1177/10556656261422855. Epub 2026 Mar 13. PMID- 41822918 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260920 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Psychometric development and validation of the paternal breastfeeding support scale in Chinese mothers: a methodological cross-sectional study. PG - 1761054 LID - 10.3389/fpubh.2026.1761054 [doi] LID - 1761054 AB - BACKGROUND: Paternal support significantly influences breastfeeding success; however, culturally appropriate measurement tools are limited in China. This study aimed to develop and validate the Paternal Breastfeeding Support Scale (PBSS-22) through the systematic cross-cultural adaptation of the Hughes Breastfeeding Support Scale for Chinese healthcare contexts. METHODS: A cross-sectional psychometric validation study was conducted at a tertiary hospital in Hangzhou, China, between October 2018 and October 2019. The Hughes Breastfeeding Support Scale underwent cross-cultural adaptation, including forward-backward translation, expert review (n = 6), and cognitive interviews (n = 30). Postpartum women at 42 days post-delivery were recruited through convenience sampling. Psychometric evaluation comprised four complementary analytical approaches: (1) comprehensive eight-method item analysis encompassing response distribution evaluation, independent-samples t-tests for discrimination, Spearman and Pearson correlation analyses, and internal consistency diagnostics; (2) exploratory factor analysis using principal component extraction with promax rotation, preceded by Kaiser-Meyer-Olkin and Bartlett's test verification of data suitability; (3) content validity assessment through Item-level Content Validity Index (I-CVI), Scale-level Content Validity Index for Universal Agreement (S-CVI/UA), and Scale-level Content Validity Index for Average Agreement (S-CVI/Ave); and (4) reliability estimation using Cronbach's alpha and Spearman-Brown split-half reliability coefficients. All analyses were performed using SPSS 20.0, with statistical significance set at p < 0.05. RESULTS: Of the 300 recruited participants, 229 provided valid responses (76.3% response rate). Participants had a mean age of 30.97 +/- 4.27 years, with 67.7% practicing exclusive breastfeeding. Following systematic item analysis and factor extraction, the final 22-item scale demonstrated a four-factor structure: Emotional Support (8 items, factor loadings 0.687-0.938), Informational Support (4 items, 0.610-0.862), Practical Assistance (6 items, 0.547-0.857), and Childcare Support (4 items, 0.468-0.964). The four factors explained 66.5% of the total variance. Content validity indices showed strong expert consensus (S-CVI/Ave = 0.946, I-CVI range 0.70-1.00). Internal consistency was excellent (Cronbach's alpha = 0.935 overall, 0.803-0.927 for subscales), with a split-half reliability of 0.857. CONCLUSION: The PBSS-22 demonstrates robust psychometric properties and cultural appropriateness for measuring multidimensional paternal breastfeeding support in the Chinese population. This validated instrument enables the targeted assessment of support deficiencies and the development of evidence-based, family centered interventions to enhance breastfeeding outcomes. CI - Copyright (c) 2026 Fan. FAU - Fan, Danfeng AU - Fan D AD - Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260225 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Psychometrics MH - Cross-Sectional Studies MH - China MH - *Breast Feeding/psychology MH - Adult MH - Female MH - Reproducibility of Results MH - *Mothers/psychology/statistics & numerical data MH - *Fathers/psychology MH - Surveys and Questionnaires/standards MH - Male MH - *Social Support MH - Family Support PMC - PMC12975968 OTO - NOTNLM OT - China OT - breastfeeding OT - cross-cultural adaptation OT - paternal support OT - psychometric validation OT - reliability OT - scale development OT - validity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/13 06:52 MHDA- 2026/03/13 06:53 PMCR- 2026/02/25 CRDT- 2026/03/13 04:56 PHST- 2025/12/05 00:00 [received] PHST- 2026/01/28 00:00 [revised] PHST- 2026/02/03 00:00 [accepted] PHST- 2026/03/13 06:53 [medline] PHST- 2026/03/13 06:52 [pubmed] PHST- 2026/03/13 04:56 [entrez] PHST- 2026/02/25 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1761054 [doi] PST - epublish SO - Front Public Health. 2026 Feb 25;14:1761054. doi: 10.3389/fpubh.2026.1761054. eCollection 2026. PMID- 41821066 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Mar 12 TI - Association between family sports environment and adolescent physical activity: the mediating role of basic psychological needs and the moderating role of academic stress. LID - 10.1186/s40359-026-04299-7 [doi] LID - 569 AB - PURPOSE: Rooted in the integration of Self-Determination Theory (SDT) and Conservation of Resources Theory (COR), this study aims to explore the associations linking family sports environment to adolescent Moderate-to-Vigorous Physical Activity (MVPA). Specifically, it examines the mediating role of basic psychological needs satisfaction and the conditional indirect effects of academic stress on this mediated pathway. METHODS: A multi-stage hybrid sampling method was employed to recruit 523 adolescents (Mean Age = 15.23, SD = 1.76) from six secondary schools across Eastern, Central, and Western China. Participants completed the Family Sports Environment Scale, the Basic Psychological Needs in Exercise Scale, and the Adolescent Academic Stress Scale. Physical activity was objectively measured using ActiGraph GT3X+ accelerometers (valid wear time >/= 4 days, including 1 weekend day). Parental education level and BMI were included as covariates. Data were analyzed using SPSS 26.0 and the PROCESS macro (Model 59). RESULTS: (1) Measurement model assessment confirmed satisfactory reliability and validity for all constructs. (2) Family sports environment was significantly and positively associated with adolescent MVPA (beta= 0.15,[Formula: see text]), with basic psychological needs serving as a significant mediating pathway. (3) Academic stress was observed as a "dual-stage" moderator: it negatively moderated the first stage of the theoretically linked pathway (family environment [Formula: see text] needs satisfaction), consistent with the resource depletion hypothesis; conversely, it positively moderated the second stage (needs satisfaction [Formula: see text] MVPA), consistent with the compensatory coping hypothesis. Crucially, despite these opposing moderating effects, the overall indirect effect of family environment on MVPA remained robust and stable across low, medium, and high levels of academic stress. CONCLUSION: The findings suggest a complex homeostatic dynamic where the opposing moderating effects of academic stress counterbalance each other. While high stress may attenuate the perception of family support, it simultaneously amplifies the motivation to engage in physical activity when psychological needs are satisfied. These results highlight the potential resilience of family support as a resource for adolescent health behaviors. FAU - Li, Wenqiong AU - Li W AD - School of Physical Education, Shandong University of Aeronautics and Astronautics, Shandong, China. FAU - Jia, Hui AU - Jia H AUID- ORCID: 0009-0009-3035-5981 AD - ZhengZhou University, Zhengzhou, China. FAU - Han, Chongyang AU - Han C AD - Tianjin Medical University, Tianjin, China. FAU - Ma, Dongdong AU - Ma D AD - Tianjin Medical University, Tianjin, China. madongdon@126.com. LA - eng PT - Journal Article DEP - 20260312 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Adolescent MH - *Sports/psychology MH - *Exercise/psychology MH - *Stress, Psychological/psychology MH - Female MH - Male MH - China MH - *Family/psychology MH - Academia MH - Personal Satisfaction MH - *Adolescent Behavior/psychology PMC - PMC13097537 OTO - NOTNLM OT - Academic Stress OT - Accelerometry OT - Basic Psychological Needs OT - Family Sports Environment OT - Moderate-to-Vigorous Physical Activity (MVPA) OT - Self-Determination Theory COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki. The research protocol was approved by the Ethics Committee of Tianjin Medical University (Approval No. TMU-REC-2024-068). Informed written consent was obtained from all legal guardians of the adolescent participants, and verbal assent was provided by the adolescent participants themselves. All study procedures were performed with the full understanding and cooperation of the participants. Competing interests: The authors declare no competing interests. EDAT- 2026/03/13 06:52 MHDA- 2026/06/28 13:04 PMCR- 2026/03/12 CRDT- 2026/03/13 01:09 PHST- 2026/01/25 00:00 [received] PHST- 2026/03/02 00:00 [accepted] PHST- 2026/06/28 13:04 [medline] PHST- 2026/03/13 06:52 [pubmed] PHST- 2026/03/13 01:09 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - 10.1186/s40359-026-04299-7 [pii] AID - 4299 [pii] AID - 10.1186/s40359-026-04299-7 [doi] PST - epublish SO - BMC Psychol. 2026 Mar 12;14(1):569. doi: 10.1186/s40359-026-04299-7. PMID- 41820889 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Mar 12 TI - Prospective acceptability, feasibility and outcomes of a primary school-led outdoor play intervention for young children. LID - 10.1186/s12889-026-26846-y [doi] LID - 1426 AB - BACKGROUND: Outdoor play benefits children's mental wellbeing, social and cognitive development and physical activity levels. However, children's outdoor play and physical activity have declined in recent years and barriers exist within their physical and social environment. Forest Schools (FS) can encourage outdoor play through familiarisation with local green spaces, but suitable spaces are limited in dense urban areas. The Play in Urban Spaces for Health (PUSH) intervention is a concept involving the use of primary school staff to support familiarisation of and regular play in local outdoor urban spaces for children aged 4-7 years. This could facilitate sustained behaviour change, whereby children use these sites with their families and have the capability and motivation to create opportunities for play within other outdoor urban spaces. The aim of this research study was to explore the prospective acceptability and feasibility of the school-led outdoor play intervention element of PUSH considering: (1) The acceptability of PUSH among primary school teaching staff and their perceived barriers and facilitators to implementation, and (2) The learning from people involved in strategic oversight and delivery of FS in urban areas, and perceived outcomes of FS. METHODS: 18 semi-structured interviews were conducted in Bradford, Yorkshire and Tower Hamlets, London UK using co-created topic guides: eight with teachers and headteachers at primary schools near potential urban play spaces to explore acceptability, and barriers and facilitators to potential future implementation of PUSH; and ten with staff involved in strategic oversight or delivery of FS through primary schools (either primary school staff or staff from private FS providers who are commissioned by schools) to capture learning and outcomes from taking children to local green spaces for outdoor play. Interview audio files were transcribed verbatim and coded deductively to explore acceptability using the theoretical framework of acceptability and inductively drawing on whole systems thinking to explore feasibility. This was subsequently followed by generation and revision of feasibility themes. The findings were used alongside insight from the broader PUSH research and academic literature to subsequently develop a theory of change and logic model. RESULTS: PUSH was generally found to be acceptable. Anticipated outcomes of PUSH aligned with those perceived by participants involved in FS. Potential barriers to implementing PUSH included curriculum pressures and safety of public spaces. However, the learning from staff involved in delivering FS provided potential solutions to incorporate into the intervention design. This included linking outdoor play to the curriculum, implementing safety rules with children when at public sites, and ensuring parents are informed of where children are being taken and of the importance of outdoor play for academic learning. The findings informed the intervention theory of change and logic model for the purpose of identifying potential mechanisms of change and guiding future implementation and evaluation. CONCLUSIONS: This study offers preliminary evidence to support the delivery of the PUSH intervention within primary schools, which may support children's habitual outdoor play. The findings emphasise the need to incorporate activities to ensure parent and staff buy-in prior to a pilot project. FAU - Seims, Amanda Louise AU - Seims AL AD - Bradford Teaching Hospitals Foundation Trust, Bradford Institute for Health Research, Bradford, BD9 6RJ, UK. a.seims@lancaster.ac.uk. AD - Division of Health Research, Lancaster University, Lancaster, LA1 4YW, UK. a.seims@lancaster.ac.uk. FAU - Ranken, Emily AU - Ranken E AD - Helen Hamlyn Centre for Pedagogy (HHCP), University College London, London, WC1E 6BT, UK. FAU - Hauari, Hanan AU - Hauari H AD - Thomas Coram Research Unit, University College London, London, WC1H 0NU, UK. FAU - Ewles, Laurence AU - Ewles L AD - Bradford Teaching Hospitals Foundation Trust, Bradford Institute for Health Research, Bradford, BD9 6RJ, UK. FAU - Midouhas, Emily AU - Midouhas E AD - Psychology and Human Development, UCL Institute of Education, University College London, London, WC1H 0AL, UK. FAU - Christie, Nicola AU - Christie N AD - Centre for Transport Studies, Department of Civil, Environmental and Geomatic Engineering, University College London, London, WC1E 6BT, UK. FAU - Rance, Tom AU - Rance T AD - MRC Epidemiology Unit, University of Cambridge School of Medicine, Cambridge, CB2 0SL, UK. FAU - Cameron, Claire AU - Cameron C AD - Thomas Coram Research Unit, University College London, London, WC1H 0NU, UK. FAU - Barber, Sally E AU - Barber SE AD - Bradford Teaching Hospitals Foundation Trust, Bradford Institute for Health Research, Bradford, BD9 6RJ, UK. LA - eng GR - NIHR204232/National Institute for Health and Care Research/ GR - MR/S037527/1/Act Early UK Prevention Research Partnership/ PT - Journal Article DEP - 20260312 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Child MH - *Play and Playthings MH - Feasibility Studies MH - *Schools MH - Child, Preschool MH - Prospective Studies MH - Male MH - Female MH - Interviews as Topic MH - *Health Promotion/methods MH - Program Evaluation MH - Qualitative Research PMC - PMC13130504 OTO - NOTNLM OT - Child development OT - Child-friendly cities OT - Children's rights OT - Play sufficiency OT - Urban regeneration OT - Whole system COIS- Declarations. Ethics approval and consent to participate: The research was conducted in accordance with the Declaration of Helsinki. Ethics approval was granted by University College London's IOE Research Ethics Committee (REC1787, data protection registration number Z6364106/2023/03/71). Consent for publication: Data were anonymised and consent was obtained from all participants to use their anonymised quotes within research publications. Competing interests: The authors declare no competing interests. EDAT- 2026/03/13 06:52 MHDA- 2026/06/27 12:36 PMCR- 2026/03/12 CRDT- 2026/03/13 00:53 PHST- 2025/09/24 00:00 [received] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/06/27 12:36 [medline] PHST- 2026/03/13 06:52 [pubmed] PHST- 2026/03/13 00:53 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - 10.1186/s12889-026-26846-y [pii] AID - 26846 [pii] AID - 10.1186/s12889-026-26846-y [doi] PST - epublish SO - BMC Public Health. 2026 Mar 12;26(1):1426. doi: 10.1186/s12889-026-26846-y. PMID- 41820626 OWN - NLM STAT- Publisher LR - 20260313 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) DP - 2026 Mar 12 TI - MiR-182-5p, miR-122-5p and hsa-piR-28004 as indicators of disease and treatment in pediatric familial hypercholesterolemia. LID - 10.1038/s41390-026-04894-9 [doi] AB - BACKGROUND: Familial hypercholesterolemia (FH) is the most common inborn metabolic disease, characterized by elevated low-density lipoprotein cholesterol (LDL-C) levels and increased risk for premature cardiovascular disease (CVD). Non-coding RNAs (ncRNAs) are promising biomarkers in CVD, but their role in pediatric FH remains unclear. We investigated circulating ncRNAs in pediatric heterozygous FH (heFH), focusing on lipid-lowering regimens and cardiovascular risk. METHODS: Fifty-one heFH patients and 17 controls (age 5-19 years) were prospectively enrolled and fasting serum and clinical data, including carotid intima-media thickness (cIMT) and echocardiography, collected. Small RNA sequencing was followed by targeted qPCR validation of candidate ncRNAs. Subgroup analyses compared newly diagnosed, diet-treated, and pharmacological lipid-lowering therapy (LLT)-obtaining patients. Additionally, miRNAs formerly described as atherosclerosis-associated were assessed. RESULTS: MiR-182-5p (p = 0.012) and hsa-piR-28004 (p = 0.024) were significantly downregulated in newly diagnosed heFH patients vs. controls. MiR-122-5p was significantly upregulated in patients under LLT compared to both newly diagnosed patients (p = 0.037) and controls (p = 0.013). Hsa-piR-28004 expression levels correlated with oxidized LDL (r = 0.345, p = 0.005), HDL-C (r = -0.282; p = 0.023) and cIMT (r approximately -0.34, p = < 0.01). CONCLUSION: MiR-182-5p and hsa-piR-28004 may serve as early indicators of disease, independent of traditional risk factors. Upregulation of miR-122-5p under LLT suggests involvement in treatment response. IMPACT: This is the first comprehensive profiling of both microRNAs (miRNAs) and piwi-interacting RNAs (piRNAs) in children and adolescents with heterozygous familial hypercholesterolemia (heFH). Circulating miR-182-5p, miR-122-5p and hsa-piR-28004 are potential early indicators of disease and treatment response in pediatric heFH. MiRNAs identified to be associated with atherosclerosis in adults are not robustly expressed in pediatric heFH, underscoring age-specific molecular differences. These findings support the potential of non-coding RNAs (ncRNAs) as non-invasive biomarkers for improved diagnosis, monitoring, and personalized risk assessment in children and adolescents with heFH beyond traditional lipid metrics. CI - (c) 2026. The Author(s). FAU - Mair, Katharina Sophia AU - Mair KS AD - Division of Pediatric Pulmonology, Allergology and Endocrinology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. FAU - Baumgartner-Kaut, Margot AU - Baumgartner-Kaut M AD - Division of Pediatric Pulmonology, Allergology and Endocrinology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. FAU - Lischka, Julia AU - Lischka J AD - Division of Pediatric Pulmonology, Allergology and Endocrinology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. AD - Department of Pediatrics, Paracelsus Medical University, Salzburg, Austria. AD - Obesity Research Unit, Paracelsus Medical University, Salzburg, Austria. FAU - Nigmann, Charlotte AU - Nigmann C AD - Division of Pediatric Pulmonology, Allergology and Endocrinology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. FAU - Neyer, Manuela AU - Neyer M AD - Division of Pediatric Pulmonology, Allergology and Endocrinology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. FAU - Schanzer, Andrea AU - Schanzer A AD - Division of Pediatric Pulmonology, Allergology and Endocrinology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. FAU - Gradwohl, Maria AU - Gradwohl M AD - Division of Pediatric Pulmonology, Allergology and Endocrinology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. FAU - Giurgea, Georgiana-Aura AU - Giurgea GA AD - Division of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria. FAU - Pesau, Gerfried AU - Pesau G AD - Division of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria. FAU - Willfort-Ehringer, Andrea AU - Willfort-Ehringer A AD - Division of Angiology, Department of Medicine II, Medical University of Vienna, Vienna, Austria. FAU - Heno, Julian AU - Heno J AD - Division of Pediatric Cardiology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. FAU - Michel-Behnke, Ina AU - Michel-Behnke I AD - Division of Pediatric Cardiology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. FAU - Greber-Platzer, Susanne AU - Greber-Platzer S AD - Division of Pediatric Pulmonology, Allergology and Endocrinology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. FAU - Zeyda, Maximilian AU - Zeyda M AD - Division of Pediatric Pulmonology, Allergology and Endocrinology, Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria. maximilian.zeyda@meduniwien.ac.at. LA - eng PT - Journal Article DEP - 20260312 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM COIS- Competing interests: The authors declare no competing interests. Ethical approval: This study was approved by the Ethics Committee of the Medical University of Vienna (No. 2003/2020) and conducted in accordance with the guidelines of the Declaration of Helsinki. Informed consent: Written informed consent was obtained from the legal guardians of all participants prior to any study procedures. In addition, assent was obtained from participants aged 8 years or older, in accordance with ethical guidelines. EDAT- 2026/03/13 06:52 MHDA- 2026/03/13 06:52 CRDT- 2026/03/13 00:36 PHST- 2025/08/20 00:00 [received] PHST- 2026/01/25 00:00 [accepted] PHST- 2025/12/16 00:00 [revised] PHST- 2026/03/13 06:52 [medline] PHST- 2026/03/13 06:52 [pubmed] PHST- 2026/03/13 00:36 [entrez] AID - 10.1038/s41390-026-04894-9 [pii] AID - 10.1038/s41390-026-04894-9 [doi] PST - aheadofprint SO - Pediatr Res. 2026 Mar 12. doi: 10.1038/s41390-026-04894-9. PMID- 41820476 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 12 TI - Sleep awake detection from leg-worn wearables using deep sensor fusion. LID - 10.1038/s41598-026-42310-8 [doi] LID - 9930 AB - Restful sleep is essential for health, yet many children with Attention Deficit Hyperactivity Disorder (ADHD) experience disturbances such as delayed sleep onset, shorter total sleep time, frequent awakenings, and daytime fatigue. Accurate detection of these issues is important for clinical care, but existing tools have limitations: polysomnography is costly and complex, while wrist devices often miss subtle movement or physiological changes. This study introduces a deep learning approach using data from RestEaze, a leg-worn multimodal wearable that records photoplethysmography (PPG), motion from accelerometer and gyroscope, and temperature signals. Overnight recordings were collected from 14 children referred for ADHD evaluation. A Support Vector Machine (SVM) using handcrafted features was implemented to establish a traditional baseline. Two convolutional neural network (CNN-BiLSTM) models were then developed, employing early and late-fusion of raw multimodal inputs to classify sleep and wake states in short windows. The late-fusion model achieved an area under the ROC curve of 90.94% in five-fold cross-validation. Derived metrics included total sleep time, wake after sleep onset, sleep onset latency, and awakenings. A temporal label-smoothing method further improved consistency. These findings demonstrate the feasibility of leg-based multimodal sensing and deep learning for noninvasive sleep monitoring in pediatric neurodevelopmental populations. CI - (c) 2026. The Author(s). FAU - Anwar, Yumna AU - Anwar Y AD - Department of Computer Science and Electrical Engineering, University of Maryland Baltimore County, Baltimore, MD, USA. FAU - Bansal, Kanika AU - Bansal K AD - Department of Computer Science and Electrical Engineering, University of Maryland Baltimore County, Baltimore, MD, USA. AD - Humans in Complex Systems Division, US Army DEVCOM Army Research Laboratory, Aberdeen, MD, USA. FAU - Kucukosmanoglu, Murat AU - Kucukosmanoglu M AD - D-Prime LLC, McLean, VA, 22101, USA. murat.kucukosmanoglu@dprime.ai. FAU - Dang, Quang AU - Dang Q AD - Department of Computer Science and Electrical Engineering, University of Maryland Baltimore County, Baltimore, MD, USA. FAU - Feltch, Cody AU - Feltch C AD - Tanzen Medical Inc., Severna Park, MD, 21146, USA. FAU - Brooks, Justin AU - Brooks J AD - Department of Computer Science and Electrical Engineering, University of Maryland Baltimore County, Baltimore, MD, USA. AD - D-Prime LLC, McLean, VA, 22101, USA. AD - Tanzen Medical Inc., Severna Park, MD, 21146, USA. FAU - Banerjee, Nilanjan AU - Banerjee N AD - Department of Computer Science and Electrical Engineering, University of Maryland Baltimore County, Baltimore, MD, USA. AD - Tanzen Medical Inc., Severna Park, MD, 21146, USA. LA - eng GR - 1R43MH133495-01A1/NH/NIH HHS/United States PT - Journal Article DEP - 20260312 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Wearable Electronic Devices MH - *Wakefulness/physiology MH - *Sleep/physiology MH - Child MH - Female MH - Male MH - Polysomnography/methods/instrumentation MH - Deep Learning MH - Photoplethysmography MH - Leg/physiology MH - *Attention Deficit Disorder with Hyperactivity/physiopathology/diagnosis MH - Support Vector Machine MH - Convolutional Neural Networks MH - Accelerometry MH - Sleep Duration PMC - PMC13018206 OTO - NOTNLM OT - ADHD OT - CNN-BiLSTM OT - Deep learning OT - RestEaze OT - Sleep classification OT - Wearable sensors COIS- Declarations. Competing interests: JB, CF, and NB are shareholders of Tanzen Medical Inc., the company that developed the RestEazeTM device evaluated in this study. All other authors declare that they have no competing interests. EDAT- 2026/03/13 06:52 MHDA- 2026/03/26 07:09 PMCR- 2026/03/12 CRDT- 2026/03/13 00:29 PHST- 2025/06/24 00:00 [received] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/03/26 07:09 [medline] PHST- 2026/03/13 06:52 [pubmed] PHST- 2026/03/13 00:29 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - 10.1038/s41598-026-42310-8 [pii] AID - 42310 [pii] AID - 10.1038/s41598-026-42310-8 [doi] PST - epublish SO - Sci Rep. 2026 Mar 12;16(1):9930. doi: 10.1038/s41598-026-42310-8. PMID- 41819267 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260718 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 222 DP - 2026 Jul 1 TI - The Food Motivation Battery [FMB]: preliminary validation of an acute, item-specific measure of food motivation in young adults. PG - 108535 LID - S0195-6663(26)00097-8 [pii] LID - 10.1016/j.appet.2026.108535 [doi] AB - Food motivation, defined as the amount of effort an individual is willing to exert to obtain food, influences energy intake and body weight. However, standard measures typically assess limited forms of effort within laboratory paradigms and do not capture variation across food types, restricting their ecological validity. We developed and preliminarily validated the Food Motivation Battery [FMB], a novel questionnaire assessing multiple dimensions of food-specific motivation. A college sample (n = 758) completed the FMB after selecting one high-energy-density (ED) sweet (e.g., cookie, brownie, or ice cream) and one low-ED fruit (e.g., watermelon, strawberries, apple, or banana). Participants answered food-specific motivation questions, including willingness to do finger taps (low effort), jumping jacks (high effort), and to pay for 20-min hypothetical food delivery, alongside established appetite measures (liking, wanting, prospective consumption). Eating behavior traits, subjective current appetite, arousal state, and past 7-day intake were assessed for construct validity. We evaluated differences in mean FMB scores by sex and BMI, examined associations with related constructs, and assessed intercorrelations among FMB items. Males scored higher on willingness to do jumping jacks for fruits than females. BMI was positively associated with motivation for sweets. Participants with overweight or obesity reported higher willingness to pay for sweets compared to those with lower weight. FMB scores were positively associated with food approach traits, hunger, desire to eat, boredom, and recent intake of sweets and fruits, and negatively associated with food avoidance traits and fullness. Novel motivation items were moderately correlated with established appetite items, suggesting they capture related but unique constructs. Findings support the FMB as a brief, multidimensional tool that complements existing appetite assessments and may enhance evaluation of food-specific motivation in clinical and population-based settings. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Hua, Shuxian AU - Hua S AD - Division of Child & Adolescent Psychiatry, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, United States. Electronic address: shhua@unc.edu. FAU - Wu, Tingjia AU - Wu T AD - Division of Child & Adolescent Psychiatry, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, United States. FAU - Atanda-Ogunleye, Olufisayo AU - Atanda-Ogunleye O AD - Division of Child & Adolescent Psychiatry, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, United States. FAU - Ibrahim, Abdulmumin AU - Ibrahim A AD - Division of Child & Adolescent Psychiatry, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, United States. FAU - Jansen, Elena AU - Jansen E AD - Division of Child & Adolescent Psychiatry, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, United States. FAU - Smith, Kimberly R AU - Smith KR AD - Division of Psychiatric Neuroimaging and Division of Behavioral Neuroscience, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, United States. FAU - Fan, Wenxuan AU - Fan W AD - Division of Child & Adolescent Psychiatry, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, United States. FAU - Chen, Liuyi AU - Chen L AD - Division of Child & Adolescent Psychiatry, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, United States. FAU - Carnell, Susan AU - Carnell S AD - Division of Child & Adolescent Psychiatry, Department of Psychiatry & Behavioral Sciences, Johns Hopkins University School of Medicine, United States. LA - eng PT - Journal Article PT - Validation Study DEP - 20260310 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - *Motivation MH - Female MH - Male MH - Appetite MH - Surveys and Questionnaires/standards MH - Young Adult MH - *Feeding Behavior/psychology MH - Energy Intake MH - Body Mass Index MH - *Food Preferences/psychology MH - Reproducibility of Results MH - Adolescent MH - Adult MH - Eating/psychology MH - Fruit OTO - NOTNLM OT - Appetite OT - Body mass index (BMI) OT - Dietary intake OT - Eating behavior OT - Food reward OT - Ultra-processed food OT - Young adults COIS- Declaration of competing interest S.C. declares previous research funding from Eli Lilly for a project unrelated to the current work. The remaining authors declare no known competing financial interests or personal relationships that could have influenced the work reported in this paper. EDAT- 2026/03/13 00:50 MHDA- 2026/05/08 00:32 CRDT- 2026/03/12 20:12 PHST- 2025/10/02 00:00 [received] PHST- 2026/03/09 00:00 [revised] PHST- 2026/03/10 00:00 [accepted] PHST- 2026/05/08 00:32 [medline] PHST- 2026/03/13 00:50 [pubmed] PHST- 2026/03/12 20:12 [entrez] AID - S0195-6663(26)00097-8 [pii] AID - 10.1016/j.appet.2026.108535 [doi] PST - ppublish SO - Appetite. 2026 Jul 1;222:108535. doi: 10.1016/j.appet.2026.108535. Epub 2026 Mar 10. PMID- 41819138 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260628 IS - 1439-3964 (Electronic) IS - 0172-4622 (Linking) VI - 47 IP - 8 DP - 2026 Jul TI - Influence of Individual Traits on Measurement Differences in Percent Body Fat. PG - 599-604 LID - 10.1055/a-2785-7668 [doi] AB - The purpose of the current study was to identify the influence of individual characteristics on differences in body fat percentage between air displacement plethysmography and dual-energy X-ray absorptiometry (change in body fat percentage) in 360 collegiate student-athletes. Body fat percentage was obtained from air displacement plethysmography and dual-energy X-ray absorptiometry. A 2 (sex)x3 (Brozek body fat percentage, Siri body fat percentage, and dual-energy x-ray absorptiometry body fat percentage) analysis of variance was used to evaluate the difference between the body fat percentages obtained from air displacement plethysmography and dual-energy x-ray absorptiometry in men and women. The agreement between air displacement plethysmography and dual-energy X-ray absorptiometry was evaluated via Bland-Altman plot and linear regression. Multiple linear regression was used to identify the influence of sex, race, height, and body mass on the change in body fat percentages. Dual-energy X-ray absorptiometry yielded greater body fat percentages in both men (4.8+/-2.8; p < 0.001) and women (2.2+/-2.9; p < 0.001) compared to air displacement plethysmography measurements. Proportional and systematic biases were observed between air displacement plethysmography and dual-energy X-ray absorptiometry. Race, height, and mass were significant predictors of the body fat percentage difference between air displacement plethysmography and dual-energy X-ray absorptiometry (R (2)=0.445, p<0.001, and standard error of the estimate=2.527). The present study suggests that air displacement plethysmography underestimates body fat percentages when compared to dual-energy X-ray absorptiometry and this underestimation may not be the same for every athlete due to their individual characteristics. CI - Thieme. All rights reserved. FAU - Magee, Meghan K AU - Magee MK AD - Health Sciences, Kent State University, Kent, USA. FAU - Miller, Angela AU - Miller A AD - Education, George Mason University, Fairfax, USA. FAU - Fields, Jennifer B AU - Fields JB AD - Nutritional Sciences, University of Connecticut, Storrs, USA. FAU - Jagim, Andrew R AU - Jagim AR AD - Sports Medicine Research, Mayo Clinic Health System, La Crosse, USA. FAU - Lockard, Brittanie AU - Lockard B AD - Kinesiology, University of the Incarnate Word, San Antonio, USA. FAU - Stroiney, Debra AU - Stroiney D AD - Kinesiology, George Mason University, Fairfax, USA. FAU - Jones, Margaret T AU - Jones MT AUID- ORCID: 0000-0003-3940-7396 AD - Sports, Recreation, and Tourism Management, George Mason University, Fairfax, USA. LA - eng PT - Journal Article DEP - 20260312 PL - Germany TA - Int J Sports Med JT - International journal of sports medicine JID - 8008349 SB - IM MH - Humans MH - *Absorptiometry, Photon MH - Male MH - *Plethysmography/methods MH - Female MH - *Adipose Tissue MH - Young Adult MH - *Body Composition MH - Sex Factors MH - Linear Models MH - Adolescent MH - Body Height MH - Body Mass Index COIS- The authors declare that they have no conflict of interest. EDAT- 2026/03/13 00:50 MHDA- 2026/06/28 13:04 CRDT- 2026/03/12 20:03 PHST- 2026/06/28 13:04 [medline] PHST- 2026/03/13 00:50 [pubmed] PHST- 2026/03/12 20:03 [entrez] AID - 10.1055/a-2785-7668 [doi] PST - ppublish SO - Int J Sports Med. 2026 Jul;47(8):599-604. doi: 10.1055/a-2785-7668. Epub 2026 Mar 12. PMID- 41818750 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260813 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Mar 12 TI - Clinical and Behavioral Outcomes During 4 Weeks of Home-Based Self-Administered Transcranial Direct Current Stimulation in Perinatal Women With Depressive Symptoms: Open-Label Exploratory Pilot Study. PG - e56454 LID - 10.2196/56454 [doi] LID - e56454 AB - BACKGROUND: Depression during the perinatal period poses significant risks to both maternal and infant health. Although transcranial direct current stimulation (tDCS) has shown promise as a safe and well-tolerated intervention for perinatal depression, empirical evidence remains limited, and no prior study has integrated clinical outcomes with continuous objective behavioral monitoring. OBJECTIVE: This pilot study aimed to evaluate the feasibility and preliminary effects of home-based tDCS combined with wearable monitoring in women with perinatal depression and to explore the correlation between behavioral and clinical measures. METHODS: In total, 38 perinatal women completed a 4-week self-administered tDCS protocol targeting the left dorsolateral prefrontal cortex (DLPFC) with 30-minute daily sessions. Participants continuously wore a wrist device (Fitbit Inspire 2) that passively collected data on the step count, distance traveled, calorie expenditure, and heart rate. Depressive symptoms were assessed at baseline (week 0), midintervention (week 2), and postintervention (week 4) using the Montgomery-Asberg Depression Rating Scale (MADRS) and the Beck Depression Inventory (BDI). Linear mixed models (LMMs) and nonparametric tests were used to evaluate changes over time, and correlations between behavioral and clinical variables were analyzed. RESULTS: Significant reductions were observed in depressive symptoms from baseline to postintervention. Mean MADRS scores decreased from 21.3 (SD 5.2) at baseline to 12.3 (SD 8.5) at week 4 (P<.001), and mean BDI scores decreased from 24.8 (SD 11.4) at baseline to 16.1 (SD 11.2) at week 4 (P<.001). Physical activity markers increased significantly: from baseline to week 4, the mean daily step count increased from 2366.8 (SD 2293.0) to 6278.7 (SD 5026.8) steps (P<.001), the mean distance traveled daily increased from 1564.6 (SD 1528.4) to 4105.9 (SD 3117.6) m (P<.001), and the mean daily calorie expenditure increased from 1130.6 (SD 759.9) to 1834.9 (SD 458.1) kcal (P<.001). However, the mean resting heart rate decreased from 85.9 (SD 9.0) to 80.4 (SD 7.0) bpm (P<.01). Exploratory correlation analyses revealed that BDI score reductions, but not MADRS changes, correlated significantly with increases in physical activity indicators (step count: r=0.401, P=.02 at week 2; r=0.351, P=.04 at week 4). CONCLUSIONS: Results showed that 4 weeks of home-based, self-administered tDCS are feasible, well tolerated, and associated with improvements in depressive symptoms and objective behavioral activity among perinatal women. Self-reported symptom changes show stronger correlations with behavioral outcomes compared to clinician-rated scores. Although the lack of a control group precludes causal inference, these findings support the feasibility of integrating wearable monitoring with tDCS protocols and warrant further validation in randomized sham-controlled trials. CI - (c)Sehwan Park, Gangho Do, Jaesub Park, Min-Kyoung Kim, Sra Jung, Hyun-Ju Kim, Hee Young Cho. Originally published in JMIR Formative Research (https://formative.jmir.org), 12.03.2026. FAU - Park, Sehwan AU - Park S AUID- ORCID: 0000-0002-4355-7453 AD - Medical Research Team, Digital Medic Co, Ltd, Seoul, Republic of Korea. FAU - Do, Gangho AU - Do G AUID- ORCID: 0009-0003-7314-1760 AD - Digital Medic Co, Ltd, Seoul, Republic of Korea. FAU - Park, Jaesub AU - Park J AUID- ORCID: 0000-0003-2597-2204 AD - Department of Psychiatry, Yongin Severance Hospital, Yonsei University College of Medicine, Yongin, Seoul, Republic of Korea. FAU - Kim, Min-Kyoung AU - Kim MK AUID- ORCID: 0000-0002-5596-5665 AD - Department of Psychiatry, CHA Ilsan Medical Center, CHA University, Goyang-si, Gyeonggi-do, Republic of Korea. FAU - Jung, Sra AU - Jung S AUID- ORCID: 0000-0001-5510-0680 AD - Department of Psychiatry, CHA Ilsan Medical Center, CHA University, Goyang-si, Gyeonggi-do, Republic of Korea. FAU - Kim, Hyun-Ju AU - Kim HJ AUID- ORCID: 0000-0002-8093-3366 AD - Department of Psychiatry, CHA Bundang Medical Center, CHA University, Seongnam, Gyeonggi-do, Republic of Korea. FAU - Cho, Hee Young AU - Cho HY AUID- ORCID: 0000-0001-7064-5056 AD - Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea. AD - Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University, Seoul, Republic of Korea. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260312 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Female MH - Pilot Projects MH - Adult MH - *Transcranial Direct Current Stimulation/methods/standards MH - *Depression/therapy/psychology MH - Pregnancy MH - Feasibility Studies MH - Treatment Outcome PMC - PMC13022536 OTO - NOTNLM OT - behavioral activation OT - digital phenotyping OT - perinatal depression OT - pilot study OT - tDCS OT - transcranial direct current stimulation OT - wearable devices COIS- Conflicts of Interest: None declared. EDAT- 2026/03/12 18:53 MHDA- 2026/03/12 18:54 PMCR- 2026/03/12 CRDT- 2026/03/12 16:53 PHST- 2025/11/18 00:00 [received] PHST- 2026/02/05 00:00 [accepted] PHST- 2026/02/04 00:00 [revised] PHST- 2026/03/12 18:54 [medline] PHST- 2026/03/12 18:53 [pubmed] PHST- 2026/03/12 16:53 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - v10i1e56454 [pii] AID - 10.2196/56454 [doi] PST - epublish SO - JMIR Form Res. 2026 Mar 12;10:e56454. doi: 10.2196/56454. PMID- 41817871 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Mar 12 TI - Relationship between obsessive personality traits and eating disorders. LID - 10.1007/s40519-026-01829-5 [doi] LID - 48 AB - This study aimed to examine associations between obsessive personality traits (perfectionism, desire for control, and cognitive flexibility) and eating-related symptomatology in a non-clinical sample of young adults. The objective was to explore which subdimensions were most strongly associated with eating attitudes. A cross-sectional study was conducted with 890 students aged 18-25 years, who completed validated self-report measures: the Eating Attitudes Test (EAT-26) (Garner and Garfinkel in Psychol Med 9(2):273-279, 1979), the Frost Multidimensional Perfectionism Scale (FMPS) (Frost et al. in Cognit Ther Res 14(5):449-468, 1990), the Desirability of Control Scale (Burger and Cooper in Motiv Emot 3(4):381-393, 1979), and the Personalised Psychological Flexibility Index (PPFI) (Kashdan et al. in Psychol Assess 32(9):829-850, 2020). Regression analyses were conducted controlling for sex and age. The results indicated statistically significant but modest associations between several subdimensions of perfectionism, cognitive flexibility, desire for control, and eating-related symptomatology. These findings expand the previous evidence on obsessive personality traits in relation to eating behaviours and should be interpreted as exploratory and correlational in nature.Level of evidence: 2 (observational, cross-sectional study). CI - (c) 2026. The Author(s). FAU - Triguero-Lopez, Maria J AU - Triguero-Lopez MJ AUID- ORCID: 0000-0002-2975-9534 AD - Department of Personality, Psychological Assessment, and Treatment, Faculty of Psychology, University of Seville, Calle Camilo Jose Cela, 41018, Seville, Spain. martrilop@alum.us.es. FAU - Moreno-Garcia, M Inmaculada AU - Moreno-Garcia MI AUID- ORCID: 0000-0002-6335-9200 AD - Department of Personality, Psychological Assessment, and Treatment, Faculty of Psychology, University of Seville, Calle Camilo Jose Cela, 41018, Seville, Spain. FAU - Morales-Ortiz, Manuel AU - Morales-Ortiz M AUID- ORCID: 0000-0002-2690-2542 AD - Department of Experimental Psychology, Faculty of Psychology, University of Seville, Calle Camilo Jose Cela, 41018, Seville, Spain. LA - eng PT - Journal Article DEP - 20260312 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - Young Adult MH - Cross-Sectional Studies MH - Female MH - Adolescent MH - Cognitive Flexibility MH - *Perfectionism MH - *Feeding and Eating Disorders/psychology MH - *Personality/physiology MH - Male MH - Adult MH - *Obsessive Behavior/psychology MH - *Feeding Behavior/psychology PMC - PMC13216079 OTO - NOTNLM OT - Cognitive flexibility OT - Desire for control OT - Eating disorders OT - Obsessive personality OT - Perfectionism COIS- Declarations. Ethics approval and consent to participate: This study was approved by the University of Seville Ethics Committee for research involving human subjects. Informed consent was obtained from all participants prior to data collection, in compliance with the ethical principles of the Declaration of Helsinki. Informed consent was obtained from all individual participants included in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/03/12 18:52 MHDA- 2026/05/28 00:30 PMCR- 2026/03/12 CRDT- 2026/03/12 12:21 PHST- 2025/08/27 00:00 [received] PHST- 2026/02/16 00:00 [accepted] PHST- 2026/05/28 00:30 [medline] PHST- 2026/03/12 18:52 [pubmed] PHST- 2026/03/12 12:21 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - 10.1007/s40519-026-01829-5 [pii] AID - 1829 [pii] AID - 10.1007/s40519-026-01829-5 [doi] PST - epublish SO - Eat Weight Disord. 2026 Mar 12;31(1):48. doi: 10.1007/s40519-026-01829-5. PMID- 41817656 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20261010 IS - 1556-2891 (Electronic) IS - 1547-769X (Linking) VI - 22 IP - 1 DP - 2026 Mar TI - Evaluation of Demirjian's and modified Demirjian staging chart by Solari and Abramovitch employing third molars: a comparative cross-sectional study. PG - 264-276 LID - 10.1007/s12024-026-01192-y [doi] AB - BACKGROUND: Ascertaining the maturation status of third molars is crucial for dental age estimation (DAE). This study aimed to evaluate and compare the effectiveness of the DAE criteria proposed by Demirjian et al. (DEM method) with the modification proposed by Solari and Abramovitch (S&A method). METHODS: In this retrospective, cross-sectional study, the maturation status of 1,351 third molars from 383 subjects was assessed using panoramic radiographs of individuals aged 7-25 years. The receiver operator characteristic curve was plotted to compare the effectiveness of the two methods, along with sensitivity and specificity, to analyze the efficacy of the individual stages for estimating ages 16 and 18. RESULTS: When considering all four third molars together, the area under the curve (AUC) was significantly greater for the S&A method. When evaluating third molars individually, only tooth 48 showed a significant difference in the AUCs of the two methods (0.005; p = 0.045) for 18 years. The specificity for stages F1 (96.99%, 95% CI: 95.09%, 98.31%) and G1 (96.29%, 95% CI: 94.72%, 97.50%) of the S&A method was higher than that for stages F (91.78%, 95% CI: 89.02, 94.04) and G (94.63%, 95% CI: 92.8, 96.10) of the DEM method for ages 16 and 18, respectively. Stages F1 (96.7%) and G1 (85.9%) of the S&A method had a higher probability of an individual being >/= 16 and >/= 18 years, respectively. CONCLUSION: Both methods were effective in estimating age; however, the S&A method demonstrated greater specificity. Mandibular third molars were more effective than combined third molars and maxillary third molars. Both methods were more accurate in males than in females. FAU - Gupta, Shruti AU - Gupta S AUID- ORCID: 0000-0002-3752-8736 AD - Department of Oral Anatomy, Post Graduate Institute of Dental Sciences, Rohtak, 124001, Haryana, India. guptashruti.82@gmail.com. FAU - Gupta, Ambika AU - Gupta A AD - Department of Oral Medicine and Radiology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India. FAU - Kumia, Komal AU - Kumia K AD - Department of Oral Medicine and Radiology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India. FAU - Hooda, Anita AU - Hooda A AD - Department of Oral Anatomy, Post Graduate Institute of Dental Sciences, Rohtak, 124001, Haryana, India. FAU - Sharma, Deepti AU - Sharma D AD - Department of Oral & Maxillofacial Pathology, Christian Dental College, Ludhiana, Punjab, India. FAU - Kamboj, Mala AU - Kamboj M AD - Department of Oral Pathology, Post Graduate Institute of Dental Sciences, Rohtak, Haryana, India. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260312 PL - United States TA - Forensic Sci Med Pathol JT - Forensic science, medicine, and pathology JID - 101236111 SB - IM MH - Humans MH - *Molar, Third/growth & development/diagnostic imaging MH - *Age Determination by Teeth/methods MH - Adolescent MH - Cross-Sectional Studies MH - Child MH - Radiography, Panoramic MH - Female MH - Retrospective Studies MH - Male MH - Adult MH - Young Adult MH - Sensitivity and Specificity MH - ROC Curve MH - Area Under Curve OTO - NOTNLM OT - Age estimation OT - Maturation OT - Panoramic radiographs OT - Third molars COIS- Declarations. Conflict of interest: The authors declare that they have no conflict of interest. EDAT- 2026/03/12 18:53 MHDA- 2026/06/28 04:09 CRDT- 2026/03/12 12:06 PHST- 2025/05/28 00:00 [received] PHST- 2026/02/06 00:00 [accepted] PHST- 2026/06/28 04:09 [medline] PHST- 2026/03/12 18:53 [pubmed] PHST- 2026/03/12 12:06 [entrez] AID - 10.1007/s12024-026-01192-y [pii] AID - 10.1007/s12024-026-01192-y [doi] PST - ppublish SO - Forensic Sci Med Pathol. 2026 Mar;22(1):264-276. doi: 10.1007/s12024-026-01192-y. Epub 2026 Mar 12. PMID- 41817479 OWN - NLM STAT- MEDLINE DCOM- 20260613 LR - 20260813 IS - 1878-2620 (Electronic) IS - 1499-4046 (Print) IS - 1499-4046 (Linking) VI - 58 IP - 6 DP - 2026 Jun TI - More PEAS Please! Implementation Methodology of a Preschool Program Promoting Healthy Eating, Science, and Language. PG - 603-615 LID - S1499-4046(26)00005-9 [pii] LID - 10.1016/j.jneb.2026.01.006 [doi] AB - OBJECTIVE: Preschool Education in Applied Sciences (PEAS) intervention, a multicomponent intervention designed to improve teachers' science teaching self-efficacy and enhance children's fruit and vegetable consumption, science knowledge, and language development. DESIGN: A 2-group (comparison/delayed intervention) quasi-experimental design was employed. Teachers completed baseline, formative, and postintervention surveys. Intervention teachers also completed a postintervention interview. Child outcomes were assessed at 3 timepoints (baseline, preintervention, and postintervention) using validated measures. SETTING: Thirteen Head Start centers in central North Carolina. PARTICIPANTS: Ninety-four teachers (n = 44 intervention; n = 50 comparison) and 330 English-speaking children aged 3-5 years (n = 140 intervention; n = 190 comparison), based on power analysis estimates. INTERVENTION: Components included a 1-day Kick-Starter Workshop, 6 eLearning modules, PEAS teaching guide featuring 12 classroom activities, and center-based implementation supports including individualized coaching, peer learning communities, and farm to early care and education resources. MAIN OUTCOME MEASURES: Teacher outcomes included self-reported teaching self-efficacy. Child outcomes include fruit and vegetable consumption (skin carotenoids via Veggie Meter(R)), height/weight, science knowledge, and academic vocabulary. ANALYSIS: Quantitative data were analyzed using descriptive statistics, paired t tests, Wilcoxon signed-rank tests, and regression models. Qualitative data were analyzed phenomenologically. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Stage, Virginia C AU - Stage VC AD - Department of Agricultural and Human Sciences, North Carolina State University, North Carolina State Extension, Raleigh, NC. Electronic address: virginia_stage@ncsu.edu. FAU - Dixon, Jocelyn B AU - Dixon JB AD - Department of Agricultural and Human Sciences, North Carolina State University, North Carolina State Extension, Raleigh, NC. FAU - Lundquist, Ryan AU - Lundquist R AD - Department of Agricultural and Human Sciences, North Carolina State University, North Carolina State Extension, Raleigh, NC. FAU - Wu, Qiang AU - Wu Q AD - Department of Public Health, East Carolina University, Greenville, NC. FAU - Hegde, Archana V AU - Hegde AV AD - Department of Human Development and Family Science, College of Health and Human Performance, East Carolina University, Greenville, NC. FAU - Lee, Tammy D AU - Lee TD AD - Department of Mathematics, Science, and Instructional Technology Education, College of Education, East Carolina University, Greenville, NC. FAU - Grist, Pauline AU - Grist P AD - Department of Agricultural and Human Sciences, North Carolina State University, North Carolina State Extension, Raleigh, NC. FAU - Goodell, L Suzanne AU - Goodell LS AD - Department of Food, Bioprocessing, and Nutrition Sciences, North Carolina State University Extension, Raleigh, NC. LA - eng GR - R25 GM132939/GM/NIGMS NIH HHS/United States PT - Journal Article DEP - 20260311 PL - United States TA - J Nutr Educ Behav JT - Journal of nutrition education and behavior JID - 101132622 SB - IM MH - Humans MH - Child, Preschool MH - *Diet, Healthy/methods MH - *Health Promotion/methods MH - North Carolina MH - Female MH - Male MH - Fruit MH - Vegetables MH - Self Efficacy MH - Health Knowledge, Attitudes, Practice PMC - PMC13363033 MID - NIHMS2189666 OTO - NOTNLM OT - Head Start OT - STEAM OT - food-based learning OT - fruit and vegetable consumption OT - preschool COIS- CONFLICT OF INTEREST DISCLOSURE The authors have not stated any conflicts of interest. EDAT- 2026/03/12 13:56 MHDA- 2026/06/15 11:35 PMCR- 2026/07/13 CRDT- 2026/03/12 11:27 PHST- 2025/04/08 00:00 [received] PHST- 2026/01/06 00:00 [revised] PHST- 2026/01/08 00:00 [accepted] PHST- 2026/06/15 11:35 [medline] PHST- 2026/03/12 13:56 [pubmed] PHST- 2026/03/12 11:27 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - S1499-4046(26)00005-9 [pii] AID - 10.1016/j.jneb.2026.01.006 [doi] PST - ppublish SO - J Nutr Educ Behav. 2026 Jun;58(6):603-615. doi: 10.1016/j.jneb.2026.01.006. Epub 2026 Mar 11. PMID- 41817418 OWN - NLM STAT- MEDLINE DCOM- 20260607 LR - 20260607 IS - 1099-0968 (Electronic) IS - 1072-4133 (Linking) VI - 34 IP - 4 DP - 2026 Jul TI - Psychometric Properties of the Commitment to Exercise Scale in Inpatients With Anorexia Nervosa and Bulimia Nervosa. PG - 1121-1129 LID - 10.1002/erv.70099 [doi] AB - OBJECTIVE: Compulsive exercise is a common behaviour among persons with eating disorders, particularly in those with anorexia nervosa (AN) and bulimia nervosa (BN). In the current study, we examined psychometric properties of a German version of the eight-item Commitment to Exercise Scale (CES) with a four-point scale response format. METHOD: Data of N = 2424 persons with AN and BN who completed the CES among other measures as part of the routine diagnostic assessment at admission to and discharge from inpatient treatment were analysed based on a preregistered protocol (https://doi.org/10.17605/OSF.IO/Z2RYW). RESULTS: The CES had high internal consistency and a one-factor structure with measurement invariance across age and diagnostic groups. Large correlations with other measures of compulsive exercise supported convergent validity and small-to-moderate correlations with other measures supported divergent validity. Scores on the CES were sensitive to change as they moderately decreased during inpatient treatment, with changes in compulsive exercise being larger in males and persons with AN that in females and persons with BN. CONCLUSIONS: The CES has sound psychometric properties in persons with AN and BN. Given its brevity, it may be favoured over lengthier instruments for assessing compulsive exercise in research and clinical practice. CI - (c) 2026 The Author(s). European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd. FAU - Fabry, Fiona M AU - Fabry FM AUID- ORCID: 0009-0004-7646-4255 AD - Department of Psychology, University of Regensburg, Regensburg, Germany. FAU - Schlegl, Sandra AU - Schlegl S AUID- ORCID: 0000-0003-1791-7379 AD - Department of Psychiatry and Psychotherapy, LMU University Hospital, Munich, Germany. FAU - Dittmer, Nina AU - Dittmer N AUID- ORCID: 0000-0001-6679-4905 AD - Schoen Clinic Roseneck, Prien am Chiemsee, Germany. FAU - Voderholzer, Ulrich AU - Voderholzer U AUID- ORCID: 0000-0003-0261-3145 AD - Department of Psychiatry and Psychotherapy, LMU University Hospital, Munich, Germany. AD - Schoen Clinic Roseneck, Prien am Chiemsee, Germany. AD - Department of Psychiatry and Psychotherapy, University Hospital of Freiburg, Freiburg im Breisgau, Germany. FAU - Kolar, David R AU - Kolar DR AUID- ORCID: 0000-0002-8649-5467 AD - Department of Psychology, University of Regensburg, Regensburg, Germany. FAU - Meule, Adrian AU - Meule A AUID- ORCID: 0000-0002-6639-8977 AD - Department of Psychology, University of Regensburg, Regensburg, Germany. LA - eng PT - Journal Article DEP - 20260312 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 SB - IM MH - Humans MH - Female MH - Psychometrics MH - *Anorexia Nervosa/psychology MH - *Bulimia Nervosa/psychology MH - Inpatients/psychology MH - Adult MH - Reproducibility of Results MH - Male MH - Young Adult MH - Adolescent MH - *Exercise/psychology MH - *Compulsive Exercise/psychology/diagnosis MH - Surveys and Questionnaires MH - Middle Aged OTO - NOTNLM OT - assessment OT - compulsive exercise OT - driven exercise OT - eating disorders OT - excessive exercise EDAT- 2026/03/12 13:57 MHDA- 2026/06/07 06:33 CRDT- 2026/03/12 10:53 PHST- 2026/02/22 00:00 [revised] PHST- 2025/11/26 00:00 [received] PHST- 2026/03/05 00:00 [accepted] PHST- 2026/06/07 06:33 [medline] PHST- 2026/03/12 13:57 [pubmed] PHST- 2026/03/12 10:53 [entrez] AID - 10.1002/erv.70099 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2026 Jul;34(4):1121-1129. doi: 10.1002/erv.70099. Epub 2026 Mar 12. PMID- 41816798 OWN - NLM STAT- MEDLINE DCOM- 20260825 LR - 20260827 IS - 1879-3479 (Electronic) IS - 0020-7292 (Print) IS - 0020-7292 (Linking) VI - 174 IP - 3 DP - 2026 Sep TI - Impact of active phase duration on neonatal and maternal adverse outcomes: A systematic analysis of parity stratification, body mass index interaction, and predictive modeling in a retrospective cohort. PG - 1350-1363 LID - 10.1002/ijgo.70932 [doi] AB - BACKGROUND: A prolonged active phase of labor is associated with adverse maternal and neonatal outcomes, but its clinical significance in contemporary obstetric populations, including the unique Chinese demographic context, and its modification by parity and body mass index (BMI) remain incompletely defined. METHODS: A single-center retrospective cohort study included 2873 women with term (>/=37 weeks), singleton, cephalic vaginal deliveries. Active phase duration (defined as time from 5 cm to 10 cm cervical dilation) was categorized into short, medium, and prolonged groups (33rd/66th percentiles). Multivariable logistic regression and restricted cubic spline (RCS) analyses were used to adjust for confounders, test interactions, and explore nonlinear trends. Predictive models incorporating active phase duration, parity, and clinical covariates were validated using area under the receiver operating characteristic curve (AUC). Primary outcomes were composite neonatal morbidity and composite maternal morbidity. Secondary outcomes included individual neonatal (e.g., neonatal intensive care unit admission and fetal distress) and maternal (e.g., postpartum hemorrhage) outcomes. RESULTS: Among nulliparous women, prolonged active phase duration significantly increased risks of composite neonatal morbidity (adjusted odds ratio [aOR] 2.08, 95% confidence interval [CI] 1.23-3.52; P = 0.006), neonatal intensive care unit admission (aOR 1.97, 95% CI 1.06-3.67; P = 0.032), fetal distress (aOR 2.47, 95% CI 1.37-4.44; P = 0.003), postpartum hemorrhage (aOR 1.62, 95% CI 1.09-2.41; P = 0.018), and composite maternal morbidity (aOR 1.74, 95% CI 1.18-2.56; P = 0.005). No significant associations were observed in multiparous women. BMI modified these relationships (P interaction <0.05), with the highest risk observed in women with BMI 24.9-27.1 kg/m(2). A nonlinear J-shaped association was identified for maternal morbidity (inflection point: 60.1 min). Predictive models demonstrated robust discrimination (AUC: 0.72-0.78) for adverse outcomes. CONCLUSION: Prolonged active phase duration independently predicts maternal and neonatal morbidity in nulliparous women, with risk amplification in specific BMI subgroups. Parity stratification and nonlinear modeling enhance individualized labor management. Clinically applicable predictive tools integrating labor progression and maternal characteristics might optimize early intervention, reducing morbidity in modern obstetric practice. CI - (c) 2026 International Federation of Gynecology and Obstetrics. FAU - Peng, Li AU - Peng L AD - Department of Obstetrics and Gynecology, the Second Xiangya Hospital, Central South University, Changsha, China. AD - Clinical Nursing Teaching and Research Section, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China. FAU - Zhang, Tingting AU - Zhang T AD - Department of Obstetrics and Gynecology, the Second Xiangya Hospital, Central South University, Changsha, China. FAU - Li, Yifan AU - Li Y AD - Department of Obstetrics and Gynecology, the Second Xiangya Hospital, Central South University, Changsha, China. FAU - Liu, Hongyu AU - Liu H AD - Department of Obstetrics and Gynecology, the Second Xiangya Hospital, Central South University, Changsha, China. FAU - Zhang, Jun AU - Zhang J AD - Department of Obstetrics and Gynecology, the Second Xiangya Hospital, Central South University, Changsha, China. FAU - Fang, Xiaoling AU - Fang X AD - Department of Obstetrics and Gynecology, the Second Xiangya Hospital, Central South University, Changsha, China. FAU - Wu, Jingni AU - Wu J AUID- ORCID: 0000-0003-2781-8622 AD - Department of Obstetrics and Gynecology, the Second Xiangya Hospital, Central South University, Changsha, China. LA - eng GR - 82201821/the National Natural Science Foundation of China/ GR - 2023JJ40859/Natural Science Foundation of Hunan Province/ PT - Journal Article DEP - 20260312 PL - United States TA - Int J Gynaecol Obstet JT - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JID - 0210174 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Retrospective Studies MH - *Body Mass Index MH - *Parity MH - Adult MH - Infant, Newborn MH - *Pregnancy Outcome/epidemiology MH - *Labor Stage, First/physiology MH - Postpartum Hemorrhage/epidemiology/etiology MH - Delivery, Obstetric MH - Logistic Models MH - Time Factors MH - *Obstetric Labor Complications/epidemiology MH - Risk Factors MH - China/epidemiology PMC - PMC13505256 OTO - NOTNLM OT - active phase duration OT - body mass index OT - neonatal outcomes OT - parity maternal morbidity OT - predictive modeling COIS- The authors confirm that there are no conflicts of interest. EDAT- 2026/03/12 07:03 MHDA- 2026/08/25 11:38 PMCR- 2026/08/25 CRDT- 2026/03/12 05:21 PHST- 2026/02/11 00:00 [revised] PHST- 2025/09/18 00:00 [received] PHST- 2026/02/18 00:00 [accepted] PHST- 2026/08/25 11:38 [medline] PHST- 2026/03/12 07:03 [pubmed] PHST- 2026/03/12 05:21 [entrez] PHST- 2026/08/25 00:00 [pmc-release] AID - IJGO70932 [pii] AID - 10.1002/ijgo.70932 [doi] PST - ppublish SO - Int J Gynaecol Obstet. 2026 Sep;174(3):1350-1363. doi: 10.1002/ijgo.70932. Epub 2026 Mar 12. PMID- 41816677 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260312 LR - 20260813 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 13 DP - 2026 TI - A novel dual elastography-based model for screening high-risk varices in hepatitis B virus-related cirrhosis. PG - 1707998 LID - 10.3389/fmed.2026.1707998 [doi] LID - 1707998 AB - BACKGROUND AND OBJECTIVE: Variceal bleeding carries high mortality and recurrence rates, underscoring the urgent need for effective non-invasive tests (NITs) to assess the severity of esophageal varices (EVs) and predict bleeding risk. This study aimed to develop and validate a robust model for safely excluding high-risk varices (HRVs) in patients with hepatitis B virus (HBV)-related cirrhosis and to compare its diagnostic performance and clinical utility with established NITs. METHODS: Consecutive patients with HBV-related cirrhosis were prospectively recruited from five centers and underwent dual elastography (dual-elasto) within 1 week of esophagogastroduodenoscopy (EGD). A training cohort from four centers was used to identify predictive variables for HRVs, which were analyzed using machine learning to develop the most reliable model. The final model was externally validated in an independent cohort from the fifth center. Diagnostic efficacy and clinical utility were compared across multiple NITs, including the Baveno VI criteria (B6C), expanded Baveno VI criteria (EB6C), platelet-spleen ratio (PSR), and RESIST-HCV criteria (RESIST). RESULTS: Among 703 screened patients, 328 were enrolled (training cohort n = 184; validation cohort n = 144). Using logistic regression, we developed the DELU model incorporating six variables: platelet count (PLT), alanine aminotransferase (ALT), ascites, portal vein thrombosis (PVT), inverse difference moment (IDM), and liver stiffness (liver Vs). DELU achieved areas under the receiver operating characteristic curve (AUROCs) of 0.822 (training) and 0.779 (validation), outperforming RESIST (0.600 and 0.626) and B6C (0.569 and 0.575). EB6C and PSR were excluded because they exceeded the 5% missed-HRV threshold. DELU demonstrated the highest spared-EGD rates (20.7% training; 11.1% validation) and maintained robust performance across subgroups, including Child-Pugh B/C (AUROC 80.3%), Child-Pugh A (79.7%), antiviral therapy (ART)-treated (82.5%), and virologically suppressed patients (84.6%). Performance was not influenced by hepatocellular carcinoma (HCC) status, sex, or body mass index (BMI). CONCLUSION: DELU is a reliable and safe non-invasive tool for excluding HRVs in HBV-related cirrhosis, providing superior diagnostic accuracy and significant endoscopy-sparing potential across diverse clinical settings. RESIST may serve as a safe alternative when elastography is unavailable. CLINICAL TRIAL REGISTRATION: [ClinicalTrials.gov], identifier [NCT04640350]. CI - Copyright (c) 2026 Hu, Chen, Zheng, Yang, Zhang, Zhang, Yin, Liao, Tang, Yu, Liang and Meng. FAU - Hu, Xing AU - Hu X AD - Center of Ultrasound and Functional Diagnosis, Beijing Youan Hospital, Capital Medical University, Beijing, China. FAU - Chen, Min AU - Chen M AD - Department of Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China. FAU - Zheng, Ying AU - Zheng Y AD - Center of Ultrasound and Functional Diagnosis, Beijing Youan Hospital, Capital Medical University, Beijing, China. FAU - Yang, Xiuhua AU - Yang X AD - Department of Interventional Ultrasound, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. FAU - Zhang, Wei AU - Zhang W AD - Department of Interventional Ultrasound, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. FAU - Zhang, Yao AU - Zhang Y AD - Department of Ultrasound, Beijing Ditan Hospital, Capital Medical University, Beijing, China. FAU - Yin, Zhiyong AU - Yin Z AD - Department of Ultrasound, Beijing Ditan Hospital, Capital Medical University, Beijing, China. FAU - Liao, Jintang AU - Liao J AD - Department of Ultrasound, Xiangya Hospital, Central South University, Changsha, Hunan, China. FAU - Tang, Yangshuo AU - Tang Y AD - Department of Ultrasound, Xiangya Hospital, Central South University, Changsha, Hunan, China. FAU - Yu, Jie AU - Yu J AD - Department of Interventional Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China. FAU - Liang, Ping AU - Liang P AD - Department of Interventional Ultrasound, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China. FAU - Meng, Fankun AU - Meng F AD - Center of Ultrasound and Functional Diagnosis, Beijing Youan Hospital, Capital Medical University, Beijing, China. LA - eng SI - ClinicalTrials.gov/NCT04640350 PT - Clinical Trial PT - Journal Article DEP - 20260224 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC12971904 OTO - NOTNLM OT - cirrhosis OT - dual elastography OT - hepatitis B OT - high-risk varices OT - non-invasive test COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/12 07:03 MHDA- 2026/03/12 07:04 PMCR- 2026/02/24 CRDT- 2026/03/12 05:19 PHST- 2025/09/18 00:00 [received] PHST- 2025/12/20 00:00 [revised] PHST- 2026/01/20 00:00 [accepted] PHST- 2026/03/12 07:04 [medline] PHST- 2026/03/12 07:03 [pubmed] PHST- 2026/03/12 05:19 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - 10.3389/fmed.2026.1707998 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Feb 24;13:1707998. doi: 10.3389/fmed.2026.1707998. eCollection 2026. PMID- 41816309 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 1938-162X (Electronic) IS - 1062-6050 (Print) IS - 1062-6050 (Linking) VI - 61 IP - 3 DP - 2026 Mar TI - A Fully Virtual Graded Exertion Test Is Safe and Feasible in Symptomatic and Asymptomatic Children With Concussion. PG - 167-174 LID - 10.4085/1062-6050-0159.25 [doi] AB - CONTEXT: Current graded exertion tests (GXTs) for concussion management require specialized equipment and in-person supervision. The Montreal Virtual Exertion (MOVE) protocol is a telehealth-compatible GXT but has been tested only in pseudo-virtual conditions. OBJECTIVE: To determine the safety and feasibility of the MOVE protocol when administered remotely to children with concussion. DESIGN: Cohort study. SETTING: Virtual visit. PATIENTS OR OTHER PARTICIPANTS: Asymptomatic (9 girls, 6 boys; age = 12.9 +/- 2.7 years, time postconcussion = 40.8 +/- 19.2 days) and symptomatic (9 girls, 6 boys; age = 12.9 +/- 2.5 years, time postconcussion = 28.7 +/- 23.0 days) children with concussion were recruited from the Montreal Children's Hospital Concussion Clinic between November 2023 and June 2024. MAIN OUTCOME MEASURES: Participants completed the MOVE protocol and a follow-up visit 24 hours later over Zoom. The MOVE protocol consists of 7 plyometric exercises performed for 60 seconds with 60 seconds of rest between stages. Safety (adverse events) and feasibility measures (protocol, outcomes, intensity, and technology categories) were collected. Linear mixed models were used to evaluate exercise intensity outcomes with all other outcomes analyzed using chi-square tests. RESULTS: One participant in each group experienced a minor adverse event (symptom increase of >/=10 points on the Post-Concussion Symptom Inventory at the 24-hour visit); however, no major adverse events were reported. Mean heart rate (78.7 +/- 33.6 beats/min; P < .001) and rate of perceived exertion (4.87 +/- 1.50; P < .001) change scores increased throughout the MOVE protocol, but no main effect of group or interaction effect was observed. Feasibility outcomes were less likely to be captured during the rest period for asymptomatic children (outcomes not collected on time on 33 [31.4%] of 105 occasions) than symptomatic children (11 [11.7%] of 94 occasions; chi12 = 10.1, P < .001). Otherwise, all outcomes met the a priori definition of feasibility. CONCLUSIONS: The MOVE protocol can be safely and feasibly administered virtually. A no-equipment, virtual GXT can remove barriers to exercise testing and broaden access to best-practice concussion-management strategies. CI - (c) by the National Athletic Trainers' Association, Inc. FAU - Coupal, Julie AU - Coupal J AD - Department of Health, Kinesiology & Applied Physiology, Concordia University, Montreal, QC, Canada. FAU - Shabanova, Daria AU - Shabanova D AD - Department of Health, Kinesiology & Applied Physiology, Concordia University, Montreal, QC, Canada. FAU - Gagnon, Isabelle AU - Gagnon I AD - School of Physical and Occupational Therapy, McGill University, Montreal, QC, Canada. AD - Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada. FAU - Grilli, Lisa AU - Grilli L AD - Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada. FAU - Beaulieu, Christine AU - Beaulieu C AD - Montreal Children's Hospital, McGill University Health Centre, Montreal, QC, Canada. FAU - Teel, Elizabeth AU - Teel E AD - Department of Health, Kinesiology & Applied Physiology, Concordia University, Montreal, QC, Canada. AD - School of Health, Concordia University, Montreal, QC, Canada. LA - eng PT - Journal Article DEP - 20260304 PL - United States TA - J Athl Train JT - Journal of athletic training JID - 9301647 SB - IM MH - Humans MH - Female MH - Child MH - Male MH - Feasibility Studies MH - *Brain Concussion/diagnosis/physiopathology MH - *Exercise Test/methods MH - *Physical Exertion MH - Adolescent MH - Telemedicine MH - Cohort Studies PMC - PMC12973427 OTO - NOTNLM OT - exercise OT - mild traumatic brain injury OT - pediatrics OT - telehealth OT - telemedicine EDAT- 2026/03/12 07:03 MHDA- 2026/03/12 13:55 PMCR- 2027/03/04 CRDT- 2026/03/12 05:16 PHST- 2026/03/12 13:55 [medline] PHST- 2026/03/12 07:03 [pubmed] PHST- 2026/03/12 05:16 [entrez] PHST- 2027/03/04 00:00 [pmc-release] AID - 10.4085/1062-6050-0159.25 [doi] PST - epublish SO - J Athl Train. 2026 Mar 4;61(3):167-174. doi: 10.4085/1062-6050-0159.25. eCollection 2026 Mar. PMID- 41816243 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260312 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Prenatal exposure to metal mixtures and the risk of overweight and obesity in school-aged children: insights from metabolomic profiling. PG - 1762885 LID - 10.3389/fnut.2026.1762885 [doi] LID - 1762885 AB - BACKGROUND: Prenatal metal mixtures exposure was associated with child growth. However, long-term impact of maternal metal mixture exposure on offspring's overweight or obesity (OWO) in childhood and the potential role of metabolites remain poorly understood. METHODS: Based on a prospective cohort study, ten metals were measured and metabolomics profiling was conducted in maternal serum during pregnancy. Children's anthropometric parameters were measured at school age and OWO was defined according to the international World Health Organization (WHO) reference data. A combination of multiple regression models, variable selection models and exposome models were conducted to explore the effects of prenatal metal mixture exposure on child OWO and BMI z-score. A meet-in-the-middle (MITM) approach was employed to examine metabolites' potential role in mediating this association. RESULTS: Maternal metals exposure such as Cu and V was found to be positively associated with OWO risk based on single-metal models, with ORs being 24.171 (95% CI: 2.351-403.256) and 2.534 (95% CI: 1.273-5.623), respectively. Similarly, prenatal exposure to V was also positively associated with BMI z-scores in school-aged children (beta: 0.293, 95% CI: 0.015-0.572). Marginal association was found between Cu exposure and BMI z-scores (beta: 0.758, 95% CI: -0.001-1.517). Metabolites such as glycerophosphocholine and glycine played potential intermediate roles in the association between maternal Cu levels and OWO risk. CONCLUSION: Prenatal Cu and V exposure may have an adverse effect on school-aged childhood's OWO risk, and metabolites may play an important intermediate role. By further examining metabolite profiles, our findings offer insight into potential metabolic pathways through which prenatal metal exposure may influence childhood obesity risk, thereby extending existing epidemiological evidence with a mechanistic perspective. Multi-center population studies and in vivo studies in future are needed to validate the results. CI - Copyright (c) 2026 Yang, Sun, Yan, Zhang, Bao, Lv, Guan, Yu and Xia. FAU - Yang, Xu AU - Yang X AD - Department of Pediatrics, Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. FAU - Sun, Xian AU - Sun X AD - Preventive Health Care Department, Ligang Hospital of Jiangyin City, Wuxi, China. FAU - Yan, Chun AU - Yan C AD - Department of Pediatrics, Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. FAU - Zhang, Wen AU - Zhang W AD - Department of Pediatrics, Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. FAU - Bao, Lili AU - Bao L AD - Department of Pediatrics, Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. FAU - Lv, YuWen AU - Lv Y AD - Department of Pediatrics, Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. FAU - Guan, Quanquan AU - Guan Q AD - State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing, China. AD - Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. FAU - Yu, Yanyan AU - Yu Y AD - Department of Pediatrics, Suzhou Affiliated Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, China. FAU - Xia, Yankai AU - Xia Y AD - State Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing, China. AD - Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China. LA - eng PT - Journal Article DEP - 20260224 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12971668 OTO - NOTNLM OT - children OT - metabolomics OT - metal mixture OT - overweight and obesity OT - pregnancy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/12 07:03 MHDA- 2026/03/12 07:04 PMCR- 2026/02/24 CRDT- 2026/03/12 05:15 PHST- 2025/12/08 00:00 [received] PHST- 2026/01/30 00:00 [revised] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/03/12 07:04 [medline] PHST- 2026/03/12 07:03 [pubmed] PHST- 2026/03/12 05:15 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - 10.3389/fnut.2026.1762885 [doi] PST - epublish SO - Front Nutr. 2026 Feb 24;13:1762885. doi: 10.3389/fnut.2026.1762885. eCollection 2026. PMID- 41816238 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260312 LR - 20260920 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Body roundness index outperforms traditional obesity metrics in predicting cardiometabolic risk among children and adolescents: the EMSNGS study. PG - 1760511 LID - 10.3389/fnut.2026.1760511 [doi] LID - 1760511 AB - OBJECTIVE: Novel obesity indices, the body roundness index (BRI) and a body shape index (ABSI), have been proved to be superior over body mass index (BMI) for predicting metabolic syndrome and cardiovascular events in adults. However, their performance in pediatric populations remains unexplored. STUDY DESIGN: A large-scale cross-sectional study, Evaluation and Monitoring on School-based Nutrition and Growth in Shenzhen (EMSNGS) project, was conducted in 2021 including 4,794 children and adolescents aged 6-17 years. Quantile regression models were used to analyse factors influencing ABSI and BRI. Associations between the 2 novel obesity indices and cardiovascular metabolic risk index (CMRI) were evaluated using logistic regression and receiver operating characteristic (ROC) curves. RESULTS: In total, 1,971 participants (1,131 boys, 840 girls) exhibited CMRI >/=1. BRI was associated with pubertal development and weight status in both sexes. ABSI was only associated with weight status. BRI was associated with CMRI >/=1, whereas ABSI was not (P > 0.05). Compared with waist-to-hip ratio, waist-to-height ratio, and BMI, BRI at the 75th percentile (BRI P75th) demonstrated optimal sensitivity-specificity balance. The area under the ROC curve (95% CI), sensitivity, specificity, and Youden index were 0.752 (0.732-0.771), 71.3%, 79.1%, and 0.504 for boys and 0.693 (0.670-0.716), 61.8%, 76.8%, and 0.386 for girls, respectively. CONCLUSION: After adjustment for sex and pubertal stages, BRI P75th remained significantly associated with elevated cardiometabolic risk in children and adolescents, supporting its potential utility as an early screening indicator. CI - Copyright (c) 2026 Hu, Xu, Su, Li, Zhao, Pan and Wang. FAU - Hu, Qifa AU - Hu Q AD - Department of Endocrinology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China. AD - Department of Pediatrics, Huidong County People's Hospital, Huizhou, Guangdong, China. FAU - Xu, Zhongwei AU - Xu Z AD - Department of Endocrinology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China. FAU - Su, Zhe AU - Su Z AD - Department of Endocrinology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China. FAU - Li, Zhuoguang AU - Li Z AD - Department of Endocrinology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China. FAU - Zhao, Xiu AU - Zhao X AD - Department of Endocrinology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China. FAU - Pan, Lili AU - Pan L AD - Department of Endocrinology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China. FAU - Wang, Li AU - Wang L AD - Department of Endocrinology, Shenzhen Children's Hospital, Shenzhen, Guangdong, China. LA - eng PT - Journal Article DEP - 20260224 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 EIN - Front Nutr. 2026 Mar 26;13:1821863. doi: 10.3389/fnut.2026.1821863. PMID: 41971370 PMC - PMC12971936 OTO - NOTNLM OT - a body shape index OT - adolescent OT - body roundness index OT - cardiometabolic risk index OT - cardiovascular disease OT - children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/12 07:03 MHDA- 2026/03/12 07:04 PMCR- 2026/02/24 CRDT- 2026/03/12 05:15 PHST- 2025/12/04 00:00 [received] PHST- 2026/01/28 00:00 [revised] PHST- 2026/01/31 00:00 [accepted] PHST- 2026/03/12 07:04 [medline] PHST- 2026/03/12 07:03 [pubmed] PHST- 2026/03/12 05:15 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - 10.3389/fnut.2026.1760511 [doi] PST - epublish SO - Front Nutr. 2026 Feb 24;13:1760511. doi: 10.3389/fnut.2026.1760511. eCollection 2026. PMID- 41815964 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Nutrition literacy and socio-demographic determinants among Chinese women of childbearing age. PG - 1742415 LID - 10.3389/fpubh.2026.1742415 [doi] LID - 1742415 AB - BACKGROUND: Nutrition literacy is critical for women of childbearing age because it may shape dietary behaviors before and during pregnancy. Evidence on domain-specific nutrition literacy and associated factors in China remains limited. METHODS: A cross-sectional online survey was conducted from August 20, 2024 to March 20, 2025, with dissemination supported by three tertiary hospitals in East, North, and Middle China. Women aged 18-49 years completed an adapted Chinese Nutrition Literacy Questionnaire (CNLQ). Domain and total scores were calculated using the original protocol and transformed to a 0-100 scale, with higher scores indicating higher nutrition literacy. Adequate nutrition literacy was defined as total score >/=80. Psychometric evaluation of the adapted instrument was performed in the full analytic sample. Univariable screening (p < 0.10) was used to select predictors for multivariable linear regression (total score) and multivariable logistic regression (adequacy). RESULTS: Among 1,764 returned questionnaires, 1,391 were included after exclusions. Mean total nutrition literacy was 74.9 +/- 12.8, and 33.4% (n = 465) met the adequacy threshold. Domain scores showed a gradient: functional 77.4 +/- 13.4, interactive 75.1 +/- 13.8, and critical 69.9 +/- 14.2. In adjusted models, higher education, higher income, urban residence, and healthcare background were associated with higher total scores and higher odds of adequacy. Multimorbidity was associated with lower total score (adjusted beta = -2.55) and lower odds of adequacy (adjusted OR = 0.62). Women aged 35-49 years had higher total scores (adjusted beta = 1.67) and higher odds of adequacy (adjusted OR = 1.43) compared with those aged 18-24 years. CONCLUSION: Nutrition literacy among Chinese women of childbearing age is moderate, with critical literacy lowest. Socioeconomic factors, urban residence, healthcare background, and multimorbidity are key correlates, highlighting priorities for targeted interventions that strengthen critical appraisal skills and support women with multimorbidity. CI - Copyright (c) 2026 Meng, Chen, Pu, Zhu, Zuo, Wang, Chang, He, Zhang, Bai, Sun, Liu and Shi. FAU - Meng, Jing-Jing AU - Meng JJ AD - Department of Gynaecology and Obstetrics, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital), Suzhou, China. FAU - Chen, Jun AU - Chen J AD - Medical Services Management Department, Peking University People's Hospital, Beijing, China. FAU - Pu, Li AU - Pu L AD - Department of Gynaecology and Obstetrics, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital), Suzhou, China. FAU - Zhu, Yan AU - Zhu Y AD - Center for Health Statistics and Information, National Health Commission of People's Republic of China, Beijing, China. FAU - Zuo, Yan AU - Zuo Y AD - Department of Gynecology and Obstetrics Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. AD - West China School of Nursing, Sichuan University, Chengdu, Sichuan, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Wang, Fang AU - Wang F AD - Zoucheng People's Hospital, Zoucheng, China. FAU - Chang, Li AU - Chang L AD - Hospital Management Center, Shulan Health Group, Hangzhou, China. FAU - He, Yi-Ying AU - He YY AD - Neonatal Intensive Care Unit, Children's Hospital of Soochow University, Suzhou, China. FAU - Zhang, Jian-Jun AU - Zhang JJ AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. AD - Department of Gynecology and Obstetrics, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Bai, Zhi-Lan AU - Bai ZL AD - Department of Gynecology and Obstetrics Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. AD - West China School of Nursing, Sichuan University, Chengdu, Sichuan, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China. FAU - Sun, Si-Qin AU - Sun SQ AD - Endocrinology Department, Zoucheng People's Hospital, Zoucheng, China. FAU - Liu, Jie AU - Liu J AD - Endocrinology Department, Zoucheng People's Hospital, Zoucheng, China. FAU - Shi, Jia AU - Shi J AD - Department of Gynaecology and Obstetrics, The Fourth Affiliated Hospital of Soochow University (Suzhou Dushu Lake Hospital), Suzhou, China. LA - eng PT - Journal Article DEP - 20260224 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Chinese people SB - IM MH - Humans MH - Female MH - Adult MH - *Health Literacy/statistics & numerical data MH - China MH - Cross-Sectional Studies MH - Middle Aged MH - Adolescent MH - Young Adult MH - Socioeconomic Factors MH - Surveys and Questionnaires MH - Sociodemographic Factors MH - *Nutritional Status MH - East Asian People PMC - PMC12974174 OTO - NOTNLM OT - China OT - maternal health OT - nutrition literacy OT - reproductive health OT - socio-demographic determinants OT - women of childbearing age COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/12 07:03 MHDA- 2026/03/12 13:55 PMCR- 2026/02/24 CRDT- 2026/03/12 05:13 PHST- 2025/11/09 00:00 [received] PHST- 2026/02/05 00:00 [revised] PHST- 2026/02/05 00:00 [accepted] PHST- 2026/03/12 13:55 [medline] PHST- 2026/03/12 07:03 [pubmed] PHST- 2026/03/12 05:13 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1742415 [doi] PST - epublish SO - Front Public Health. 2026 Feb 24;14:1742415. doi: 10.3389/fpubh.2026.1742415. eCollection 2026. PMID- 41814473 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260825 IS - 2090-1844 (Electronic) IS - 2090-1836 (Print) IS - 2090-1844 (Linking) VI - 2026 IP - 1 DP - 2026 TI - Impact of Post-COVID Syndrome on Cardiorespiratory Fitness, Psychological Well-Being, and Quality of Life in Adolescents: A Cross-Sectional Study. PG - e5599011 LID - 10.1155/pm/5599011 [doi] LID - 5599011 AB - BACKGROUND: Post-COVID syndrome (PCS) in adolescents, marked by persistent symptoms such as dyspnea and fatigue, remains poorly understood, particularly in those referred for exercise intolerance. OBJECTIVE: The objective of this study is to describe the clinical presentation and cardiorespiratory fitness (CRF) of adolescents with PCS and identify factors distinguishing those with normal versus reduced CRF. STUDY DESIGN: In this cross-sectional study, 31 adolescents (90% female) with PCS underwent cardiopulmonary exercise testing (CPET), pulmonary function tests, and completed validated questionnaires assessing fatigue, depression, hyperventilation, physical activity, and quality of life (QoL). Patients were grouped by CRF status and compared. RESULTS: Symptoms were more prevalent than in general PCS literature, likely due to referral bias. Moderate depression risk was present in 35%, and 75% reported QoL impairment comparable with chronic conditions. Nearly half (48%) had reduced CRF. CRF was not associated with acute infection severity but correlated with orthostatism, reduced O(2) pulse, and increased static air trapping (p < 0.05). Preinfection physical activity was positively associated with CRF (p = 0.014), whereas postinfection activity levels were similar across groups. CONCLUSION: PCS significantly impacts CRF, QoL, and psychological well-being in adolescents with exercise intolerance. Reduced CRF appears multifactorial, involving autonomic dysfunction, pulmonary limitations, and deconditioning. These findings underscore the need for comprehensive evaluation and targeted management strategies in this vulnerable population. CI - Copyright (c) 2026 Albane Bertha Rosa Maggio et al. Pulmonary Medicine published by John Wiley & Sons Ltd. FAU - Maggio, Albane Bertha Rosa AU - Maggio ABR AUID- ORCID: 0000-0002-9110-4467 AD - Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland, hug-ge.ch. FAU - Perret, Ivan AU - Perret I AD - Faculty of Medicine, University of Geneva, Geneva, Switzerland, unige.ch. FAU - Alramadina, Nuseibah AU - Alramadina N AD - Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland, hug-ge.ch. FAU - Perrin, Anne AU - Perrin A AD - Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland, hug-ge.ch. FAU - Barazzone, Constance AU - Barazzone C AD - Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland, hug-ge.ch. FAU - Mornand, Anne AU - Mornand A AD - Department of Pediatrics, Gynecology and Obstetrics, University Hospitals of Geneva, Geneva, Switzerland, hug-ge.ch. LA - eng GR - Universite de GeneveFund source/ GR - CSAL/ PT - Journal Article PL - United States TA - Pulm Med JT - Pulmonary medicine JID - 101558762 SB - IM MH - Humans MH - Adolescent MH - *Quality of Life MH - Cross-Sectional Studies MH - Female MH - *Cardiorespiratory Fitness/physiology/psychology MH - Post-Acute COVID-19 Syndrome MH - *COVID-19/complications/psychology/physiopathology MH - Exercise Test/methods MH - Male MH - Respiratory Function Tests/methods MH - Fatigue/etiology/physiopathology MH - Psychological Well-Being MH - SARS-CoV-2 MH - Depression/etiology/epidemiology MH - Dyspnea/etiology/physiopathology MH - Pandemics MH - Exercise MH - Hyperventilation/etiology PMC - PMC13140234 OTO - NOTNLM OT - breathing pattern OT - cardiorespiratory exercise test OT - cardiorespiratory fitness OT - dysfunctional breathing OT - peak oxygen consumption OT - post- syndrome OT - pulmonary function COIS- The authors declare no conflicts of interest. EDAT- 2026/03/12 07:04 MHDA- 2026/03/12 13:55 PMCR- 2026/03/11 CRDT- 2026/03/12 01:09 PHST- 2026/01/16 00:00 [revised] PHST- 2025/12/04 00:00 [received] PHST- 2026/02/17 00:00 [accepted] PHST- 2026/03/12 13:55 [medline] PHST- 2026/03/12 07:04 [pubmed] PHST- 2026/03/12 01:09 [entrez] PHST- 2026/03/11 00:00 [pmc-release] AID - PM5599011 [pii] AID - 10.1155/pm/5599011 [doi] PST - ppublish SO - Pulm Med. 2026;2026(1):e5599011. doi: 10.1155/pm/5599011. PMID- 41814464 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1365-2982 (Electronic) IS - 1350-1925 (Print) IS - 1350-1925 (Linking) VI - 38 IP - 3 DP - 2026 Mar TI - Adolescent Normative Intervals for Body Surface Gastric Mapping: Spectral Analysis. PG - e70282 LID - 10.1111/nmo.70282 [doi] LID - e70282 AB - BACKGROUND: Body surface gastric mapping (BSGM) non-invasively assesses gastric myoelectrical activity along with real-time symptom reporting. In adults, the development of normative intervals has underpinned new explanatory phenotypes, aiding clinical decision-making. This study established normative reference intervals for adolescent BSGM metrics. METHODS: Healthy adolescents aged 12-17 years with a BMI /= 0.22. Median ff-AR was 2.12; reference interval >/= 1.0. CONCLUSIONS AND INFERENCES: This study presents normative reference intervals for BSGM spectral metrics in adolescent populations, informing the interpretation of tests in research and clinical practice. CI - (c) 2026 The Author(s). Neurogastroenterology & Motility published by John Wiley & Sons Ltd. FAU - Humphrey, Gayl AU - Humphrey G AUID- ORCID: 0000-0002-2837-5707 AD - Department of Surgery, The University of Auckland, Auckland, New Zealand. AD - Alimetry, Auckland, New Zealand. FAU - Schamberg, Gabriel AU - Schamberg G AUID- ORCID: 0000-0002-4188-9614 AD - Department of Surgery, The University of Auckland, Auckland, New Zealand. AD - Alimetry, Auckland, New Zealand. FAU - Xu, Binghong AU - Xu B AD - School of Medicine, Western Sydney University, Sydney, Australia. FAU - Dachs, Nicky AU - Dachs N AUID- ORCID: 0009-0009-3964-8086 AD - Alimetry, Auckland, New Zealand. FAU - Foong, Daphne AU - Foong D AUID- ORCID: 0000-0002-9224-1199 AD - Alimetry, Auckland, New Zealand. AD - School of Medicine, Western Sydney University, Sydney, Australia. FAU - Varghese, Chris AU - Varghese C AD - Department of Surgery, The University of Auckland, Auckland, New Zealand. AD - Division of Surgery, Mayo Clinic, Rochester, Minnesota, USA. FAU - Andrews, Christopher N AU - Andrews CN AD - Alimetry, Auckland, New Zealand. AD - Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada. FAU - Mousa, Hayat AU - Mousa H AD - Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. FAU - Gharibans, Armen AU - Gharibans A AD - Department of Surgery, The University of Auckland, Auckland, New Zealand. AD - Alimetry, Auckland, New Zealand. AD - Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. FAU - O'Grady, Gregory AU - O'Grady G AD - Department of Surgery, The University of Auckland, Auckland, New Zealand. AD - Alimetry, Auckland, New Zealand. LA - eng GR - Health Research Council of New Zealand/ GR - Children's Hospital of Philadelphia/ PT - Journal Article PL - England TA - Neurogastroenterol Motil JT - Neurogastroenterology and motility JID - 9432572 SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - Reference Values MH - Child MH - *Stomach/physiology MH - *Body Surface Potential Mapping/methods/standards MH - Postprandial Period/physiology MH - Body Mass Index PMC - PMC12979704 OTO - NOTNLM OT - adolescent OT - body surface gastric mapping (BSGM) OT - diagnostics OT - pediatric OT - phenotypes OT - reference intervals COIS- G.O. and A.G. hold grants and intellectual property in gastrointestinal electrophysiology. G.S., N.D., D.F., G.O., A.G., G.H., C.V., and C.N.A. are members of Alimetry. G.O. is a Director at The Insides Company. The remaining authors declare no conflicts of interest. EDAT- 2026/03/12 07:04 MHDA- 2026/03/12 13:56 PMCR- 2026/03/12 CRDT- 2026/03/12 01:09 PHST- 2026/02/13 00:00 [revised] PHST- 2025/12/08 00:00 [received] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/03/12 13:56 [medline] PHST- 2026/03/12 07:04 [pubmed] PHST- 2026/03/12 01:09 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - NMO70282 [pii] AID - 10.1111/nmo.70282 [doi] PST - ppublish SO - Neurogastroenterol Motil. 2026 Mar;38(3):e70282. doi: 10.1111/nmo.70282. PMID- 41814431 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260915 IS - 2046-4053 (Electronic) IS - 2046-4053 (Linking) VI - 15 IP - 1 DP - 2026 Mar 11 TI - The impact of sports participation on psychological health and social outcomes in children and adolescents: a systematic review and update to the "Mental Health through Sport" conceptual model. LID - 10.1186/s13643-026-03104-1 [doi] LID - 121 AB - BACKGROUND: Sport is a distinct, structured form of physical activity that can support psychological health and social development in children and adolescents. Compared to other forms of physical activity, the unique attributes of sport, including its combination of physical, cognitive, and social opportunities and challenges within structured goal-directed contexts, may confer additional psychological and social benefits. This systematic review synthesizes evidence on the psychological and social outcomes of sport participation in children and adolescents, and proposes an updated, developmentally informed conceptual model explaining the mechanisms through which sport supports mental health. METHODS: A systematic search was conducted across five electronic databases on 18 October 2024, with no date limits applied. Eligible studies were peer-reviewed, published in English, and focused on the relationship between sport participation and psychological and/or social outcomes in 5-17-year olds. Sport was defined as a structured form of physical activity performed individually or in teams, with established rules and a specific objective. Risk of bias was assessed using validated tools tailored to study design. RESULTS: From 17,017 records, 189 studies were included, spanning cross-sectional, longitudinal, and experimental designs. Sport participation was consistently associated with better mental health-including higher self-esteem, life satisfaction, and reduced depressive and anxiety symptoms-and enhanced social outcomes, such as improved interpersonal skills, prosocial behavior, and belonging. Team sports showed stronger and more consistent benefits than individual sports. The experimental evidence highlighted potential causal effects on emotional regulation, resilience, and prosocial behavior. Risk of bias was generally low among randomized trials, although most relied on self-report data and lacked pre-registration. Observational and quasi-experimental studies were methodologically sound but were affected by potential confounding and social desirability bias. CONCLUSIONS: This review provides compelling evidence that organized sport participation supports psychological and social development in children and adolescents. Sport was consistently associated with higher self-esteem, greater life satisfaction, and lower symptoms of depression and anxiety, with team sports showing stronger and more consistent benefits than individual sports. Social outcomes-including enhanced belonging, prosocial behavior, and interpersonal skills-were also evident, underscoring the unique contribution of sport as a social context for development. The refined conceptual model proposed here identifies self-perceptions, peer belonging, and social support as central mechanisms, offering a developmentally informed framework for leveraging sport to promote youth mental health. These findings highlight sport, especially inclusive and well-structured team sports, as a powerful setting for fostering psychological well-being and positive social outcomes, warranting prioritization in youth development policies and programs. CI - (c) 2026. The Author(s). FAU - Wade, Levi AU - Wade L AUID- ORCID: 0000-0002-4007-5336 AD - Global Sport and Movement Collaborative, University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia. AD - Hunter Medical Research Institute, New Lambton, NSW, 2308, Australia. FAU - Eime, Rochelle AU - Eime R AUID- ORCID: 0000-0002-8614-2813 AD - Health, Innovation, and Transformation Centre, Federation University Australia, University Drive, Mount Helen, Victoria, 3350, Australia. FAU - Pankowiak, Aurelie AU - Pankowiak A AUID- ORCID: 0000-0003-0178-513X AD - Institute for Health and Sport, Victoria University, Ballarat Road, Footscray, VIC, 3011, Australia. FAU - Vella, Stewart AU - Vella S AUID- ORCID: 0000-0003-0537-9366 AD - Movember Institute of Men's Health, Richmond, VIC, Australia. AD - School of Psychology, University of Wollongong, Wollongong, NSW, 2500, Australia. FAU - Robinson, Katie AU - Robinson K AUID- ORCID: 0000-0002-8347-4783 AD - Global Sport and Movement Collaborative, University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia. AD - Hunter Medical Research Institute, New Lambton, NSW, 2308, Australia. FAU - Kennedy, Sarah AU - Kennedy S AUID- ORCID: 0000-0001-9804-616X AD - Global Sport and Movement Collaborative, University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia. AD - School of Health Sciences, Western Sydney University, (Darug Country), Kingswood, NSW, 2747, Australia. AD - Translational Health Research Institute, Western Sydney University, (Dharawal Country), Campbelltown, NSW, 2560, Australia. FAU - Parkes, Rebekah AU - Parkes R AUID- ORCID: 0000-0002-3018-0810 AD - Global Sport and Movement Collaborative, University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia. FAU - Eather, Narelle AU - Eather N AUID- ORCID: 0000-0002-6320-4540 AD - Global Sport and Movement Collaborative, University of Newcastle, University Drive, Callaghan, NSW, 2308, Australia. narelle.eather@newcastle.edu.au. AD - Hunter Medical Research Institute, New Lambton, NSW, 2308, Australia. narelle.eather@newcastle.edu.au. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260311 PL - England TA - Syst Rev JT - Systematic reviews JID - 101580575 SB - IM MH - *Mental Health MH - *Youth Sports/psychology MH - Self Concept MH - Humans MH - Child, Preschool MH - Child MH - Adolescent MH - Emotional Regulation MH - Resilience, Psychological MH - *Social Behavior MH - Personal Satisfaction MH - Team Sports MH - *Psychological Well-Being MH - Child Development MH - Adolescent Development PMC - PMC13064252 OTO - NOTNLM OT - Mental health OT - Moderators OT - Organized sport OT - Youth COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/12 07:04 MHDA- 2026/04/09 06:33 PMCR- 2026/03/11 CRDT- 2026/03/12 01:06 PHST- 2025/07/24 00:00 [received] PHST- 2026/02/03 00:00 [accepted] PHST- 2026/04/09 06:33 [medline] PHST- 2026/03/12 07:04 [pubmed] PHST- 2026/03/12 01:06 [entrez] PHST- 2026/03/11 00:00 [pmc-release] AID - 10.1186/s13643-026-03104-1 [pii] AID - 3104 [pii] AID - 10.1186/s13643-026-03104-1 [doi] PST - epublish SO - Syst Rev. 2026 Mar 11;15(1):121. doi: 10.1186/s13643-026-03104-1. PMID- 41814319 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260901 IS - 1479-5876 (Electronic) IS - 1479-5876 (Linking) VI - 24 IP - 1 DP - 2026 Mar 11 TI - Untargeted metabolomics identifies altered metabolome contributing to hypertension in late adolescents. LID - 10.1186/s12967-026-07914-8 [doi] LID - 544 AB - IMPORTANCE: Childhood hypertension is a growing health problem, yet its specific biomarkers are not yet fully elucidated. OBJECTIVE: The aim of this study was to investigate the functional metabolic alteration associated with hypertension in late adolescents. DESIGN: This study employed a cluster random sampling method based on the Health Promotion Program for Children and Adolescents. In the first stage in 2020-2021, three schools were selected for hypertension screening, followed by four schools in the second stage in 2022-2023. Hypertensive students in their late adolescent were matched 1:1 with normotensive controls for an untargeted metabolomics study to identify differential metabolites. In vitro cellular experiments were further performed to explore the functional roles of the interested metabolite. SETTING: Two separate case-control studies and cellular experiments. PARTICIPANTS: In the first stage, a total of 51 late adolescents were identified with hypertension, and then were matched with 51 normotensive controls of similar sex and age from the same dormitory to collect their fasting urine samples. In the second stage, 91 hypertensive adolescents were identified and 91 matched normotensive adolescents were selected from the same dormitory to collect their fasting serum samples. MAIN OUTCOMES AND MEASURES: Hypertension was diagnosed by blood pressure measurements taken on three separate occasions. RESULTS: Detailed metabolomic evaluation revealed four distinct metabolites differentially expressed in hypertensive adolescents and control individuals in both urine and serum samples. As compared with the control group, higher levels of 2-hydroxycinnamic acid and xanthine, but lower levels of hypoxanthine and N-acetylornithine were observed in hypertensive adolescents. These metabolites also slightly enhance the discriminatory ability for hypertension based on body mass index Z score, as revealed by increased area under receiver operating characteristic curve. Notably, 2-hydroxycinnamic acid could inhibit cell proliferation, induce oxidative stress and inflammatory responses, and then disrupt the cellular function of human umbilical vein endothelial cells, inferring it as a potential detrimental metabolite for hypertension in adolescents. CONCLUSIONS AND RELEVANCE: Our result revealed distinct metabolic alterations in urine and serum samples of hypertensive adolescents. Combined with metabonomic and in vitro experiments, 2-hydroxycinnamic acid was identified as a potential detrimental metabolite for hypertension in adolescents. FAU - Wang, Ying AU - Wang Y AD - Department of Epidemiology and Health Statistics, Suzhou Medical School, Soochow University, Suzhou, China. FAU - Xin, Lili AU - Xin L AD - Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-Communicable Diseases, Suzhou Medical School, Soochow University, Suzhou, China. FAU - Ge, Wenxin AU - Ge W AD - Department of Maternal and Child Health, School of Public Health, Sun Yat-Sen University, Guangzhou, 510080, China. FAU - Yan, Weici AU - Yan W AD - Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-Communicable Diseases, Suzhou Medical School, Soochow University, Suzhou, China. FAU - Su, Yue AU - Su Y AD - Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-Communicable Diseases, Suzhou Medical School, Soochow University, Suzhou, China. FAU - Hu, Xuan AU - Hu X AD - Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-Communicable Diseases, Suzhou Medical School, Soochow University, Suzhou, China. FAU - Liang, Fei AU - Liang F AD - The First People's Hospital of Huzhou, Huzhou, Zhejiang, 313000, China. FAU - Xiao, Yue AU - Xiao Y AD - Department of Chronic Disease Management, Center for Disease Prevention and Control of Gusu District, Suzhou, China. FAU - Fu, Wanyi AU - Fu W AD - Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-Communicable Diseases, Suzhou Medical School, Soochow University, Suzhou, China. FAU - Han, Di AU - Han D AD - Department of School Health, Suzhou Center for Disease Prevention and Control, Suzhou, Jiangsu Province, China. FAU - Hu, Jia AU - Hu J AD - Department of School Health, Suzhou Center for Disease Prevention and Control, Suzhou, Jiangsu Province, China. hujia200606@163.com. AD - Suzhou Institute of Advanced Study in Public Health, Gusu School, Nanjing Medical University, Suzhou, Jiangsu Province, China. hujia200606@163.com. AD - School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, China. hujia200606@163.com. FAU - Yin, Jieyun AU - Yin J AUID- ORCID: 0000-0002-5265-3930 AD - Department of Epidemiology and Health Statistics, Suzhou Medical School, Soochow University, Suzhou, China. jyyin@suda.edu.cn. AD - Jiangsu Key Laboratory of Preventive and Translational Medicine for Major Chronic Non-Communicable Diseases, Suzhou Medical School, Soochow University, Suzhou, China. jyyin@suda.edu.cn. AD - School of Public Health, Medical College of Soochow University, 199 Renai Road, Suzhou, 215123, China. jyyin@suda.edu.cn. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260311 PL - England TA - J Transl Med JT - Journal of translational medicine JID - 101190741 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Adolescent MH - *Hypertension/blood/metabolism/urine/physiopathology MH - *Metabolomics/methods MH - *Metabolome MH - Male MH - Female MH - Case-Control Studies MH - Biomarkers/blood MH - Blood Pressure PMC - PMC13094021 OTO - NOTNLM OT - 2-hydroxycinnamic acid OT - Adolescent OT - Hypertension OT - Metabolomics COIS- Declarations. Ethics approval: This study was approved by the Ethics Committee of Soochow University and the Center for Disease Control and Prevention of Suzhou, China. The procedures used in this study adhere to the tenets of the Declaration of Helsinki. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Soochow University and the Center for Disease Control and Prevention of Suzhou, China. Sign informed consent were provided by both the participants and their parents. Consent for publication: Informed consent was obtained from all individual participants and their legal guardians included in the study. Competing interests: No potential conflict of interest was reported by the authors. EDAT- 2026/03/12 07:04 MHDA- 2026/06/27 12:38 PMCR- 2026/03/11 CRDT- 2026/03/12 00:57 PHST- 2025/09/26 00:00 [received] PHST- 2026/02/17 00:00 [accepted] PHST- 2026/06/27 12:38 [medline] PHST- 2026/03/12 07:04 [pubmed] PHST- 2026/03/12 00:57 [entrez] PHST- 2026/03/11 00:00 [pmc-release] AID - 10.1186/s12967-026-07914-8 [pii] AID - 7914 [pii] AID - 10.1186/s12967-026-07914-8 [doi] PST - epublish SO - J Transl Med. 2026 Mar 11;24(1):544. doi: 10.1186/s12967-026-07914-8. PMID- 41812539 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 1879-1484 (Electronic) IS - 0021-9150 (Linking) VI - 415 DP - 2026 Apr TI - Differential methylation of lipid metabolism and X-linked inheritance genes is associated with low placental efficiency, impaired fatty acid metabolism and oxidative stress in the placenta of hypercholesterolemic mothers. PG - 120694 LID - S0021-9150(26)00060-2 [pii] LID - 10.1016/j.atherosclerosis.2026.120694 [doi] AB - BACKGROUND: Maternal hypercholesterolemia (MHC), characterized by elevated cholesterol levels in mothers during gestation, increases the risk of atherosclerosis in offspring. This study seeks to uncover how in-utero fetal programming may be linked to changes in methylation patterns in the placenta, potentially affecting fetal gene expression. METHODS: Pregnant subjects who were within the first 100 days of gestation were recruited and classified as either normocholesterolemic (NC) or hypercholesterolemic (MHC). Lipid profiling was conducted throughout all trimesters. Post delivery, placental samples were collected, and newborn parameters were recorded. A genome-wide methylation EPIC array and histological analysis were performed on the placental samples, with results validated using quantitative real-time PCR and immunohistochemistry. RESULTS: EPIC array analysis revealed significant methylation changes in genes linked to X-linked inheritance and lipid metabolism pathways. Combined gene expression studies and histopathological analysis indicated disrupted fatty acid metabolism and elevated oxidative stress in placentas affected by maternal hypercholesterolemia (MHC). Furthermore, MHC was associated with decreased placental efficiency, lower birth weight, elongated umbilical cords in newborns. CONCLUSIONS: Maternal hypercholesterolemia is associated with methylation changes in the placenta that disrupt metabolic pathways and compromise placental function. This study offers strong experimental evidence that the MHC placenta plays a role in fetal programming, contributing to clinical manifestations in offspring. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Jayalekshmi, V S AU - Jayalekshmi VS AD - Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, Kerala, India. FAU - Basu, Budhaditya AU - Basu B AD - Rajiv Gandhi Centre for Biotechnology (RGCB), Thiruvananthapuram, Kerala, India. FAU - Srijith, Sreelekshmi AU - Srijith S AD - Kerala Institute of Medical Sciences (KIMS), Thiruvananthapuram, Kerala, India. FAU - Krishna, Geethu AU - Krishna G AD - Gujarat Biotechnology University (GBU), Gandhinagar, Gujarat, India. FAU - Rafeekha, P AU - Rafeekha P AD - Kerala Institute of Medical Sciences (KIMS), Thiruvananthapuram, Kerala, India. FAU - Vidyalekshmy, R AU - Vidyalekshmy R AD - Kerala Institute of Medical Sciences (KIMS), Thiruvananthapuram, Kerala, India. FAU - Ramachandran, Surya AU - Ramachandran S AD - Gujarat Biotechnology University (GBU), Gandhinagar, Gujarat, India. Electronic address: surya.ramachandran@gbu.edu.in. LA - eng PT - Journal Article DEP - 20260306 PL - Ireland TA - Atherosclerosis JT - Atherosclerosis JID - 0242543 RN - 0 (Fatty Acids) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Placenta/metabolism MH - *DNA Methylation MH - *Oxidative Stress MH - *Hypercholesterolemia/genetics/blood/metabolism/diagnosis MH - *Lipid Metabolism/genetics MH - *Fatty Acids/metabolism MH - Adult MH - Developmental Origins of Health and Disease MH - Epigenesis, Genetic MH - Infant, Newborn MH - *Pregnancy Complications/genetics/metabolism MH - Birth Weight MH - Genetic Predisposition to Disease OTO - NOTNLM OT - Cardiovascular diseases OT - DNA methylation OT - Maternal hypercholesterolemia OT - Placenta COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2026/03/12 01:09 MHDA- 2026/04/24 00:32 CRDT- 2026/03/11 19:12 PHST- 2025/09/18 00:00 [received] PHST- 2026/01/17 00:00 [revised] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/04/24 00:32 [medline] PHST- 2026/03/12 01:09 [pubmed] PHST- 2026/03/11 19:12 [entrez] AID - S0021-9150(26)00060-2 [pii] AID - 10.1016/j.atherosclerosis.2026.120694 [doi] PST - ppublish SO - Atherosclerosis. 2026 Apr;415:120694. doi: 10.1016/j.atherosclerosis.2026.120694. Epub 2026 Mar 6. PMID- 41812488 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260724 IS - 1879-2219 (Electronic) IS - 0966-6362 (Linking) VI - 127 DP - 2026 Jun TI - Intra- and inter-therapist reliability of lower-limb inter-joint coordination during gait in individuals with and without cerebral palsy. PG - 110148 LID - S0966-6362(26)00056-1 [pii] LID - 10.1016/j.gaitpost.2026.110148 [doi] AB - PURPOSE: Inter-joint coordination plays a key role in walking, particularly in people with cerebral palsy (CP), who experience altered movement patterns. The Continuous Relative Phase (CRP) method quantifies lower-limb coordination by assessing the phase relationships between joints. However, the reliability of CRP measurements during walking in individuals with CP remains unexplored, and may be affected by measurement variability due to marker placement errors, soft tissue artifacts, and natural movement fluctuations. Quantifying this reliability is important for appropriate clinical comparisons. This study aimed to quantify intra- and inter-therapist reliability of lower-limb CRP measurements in CP and non-impaired (NI) individuals. METHODS: CP (n = 19, age=18.4 +/- 7.3 years, GMFCS I-III) and NI (n = 19, age=18.3 +/- 11.2 years) individuals completed two gait assessment sessions, ten days apart, each including 3D motion capture of at least 10 walking trials. During one session, two trained therapists independently placed reflective markers and conducted gait analyses. Standard error of measurement (SEM) and minimal detectable change (MDC) were computed for knee-hip and ankle-knee coordination across gait subphases. RESULTS: The SEM and MDC were lower for knee-hip than ankle-knee coordination, suggesting higher measurement reliability for proximal joint coupling. For knee-hip coordination, MDC reached 15.1 +/- 0.7 degrees (CP) and 9.3 +/- 0.6 degrees (NI) inter-therapist, and 23.8 +/- 3.0 degrees (CP) and 9.1 +/- 1.6 degrees (NI) intra-therapist. For ankle-knee coordination, MDC reached 29.0 +/- 2.6 degrees (CP) and 25.0 +/- 3.5 degrees (NI) inter-therapist, peaking at 47.3 +/- 10.9 degrees (CP) and 28.6 +/- 1.5 degrees (NI) in mid-swing intra-therapist. CONCLUSIONS: This study provides the first metrological reference for reliability of CRP-based inter-joint coordination during gait in CP. Results showed poor reliability, emphazing that such measurements must be interpreted with caution. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Dussault-Picard, Cloe AU - Dussault-Picard C AD - Laboratory of Movement Analysis, Department of Physical Medicine and et Rehabilitation, Saint Jacques Hospital, CHU Nantes, Nantes, France. Electronic address: Cloe.dussaultpicard@chu-nantes.fr. FAU - Cherni, Yosra AU - Cherni Y AD - School of Kinesiology and Physical Activity Sciences, University of Montreal, Montreal, Canada; Azrieli Research Center of the CHU de Sainte-Justine, Montreal, Canada; Biomedical Ingeneering Institute, University of Montreal, Montreal, Canada. FAU - Fonseca, Mickael AU - Fonseca M AD - Kinesiology Laboratory, Geneva University Hospitals and University of Geneva, Geneva, Switzerland. FAU - Carcreff, Lena AU - Carcreff L AD - Kinesiology Laboratory, Geneva University Hospitals and University of Geneva, Geneva, Switzerland; Department of Physical Medicine and Rehabilitation and Department of Geriatric Medicine, Angers University Hospital, Angers, France. FAU - Leboeuf, Fabien AU - Leboeuf F AD - Laboratory of Movement Analysis, Department of Physical Medicine and et Rehabilitation, Saint Jacques Hospital, CHU Nantes, Nantes, France; Laboratory of Motricity, Interactions, Performance, UR4334, University of Nantes, Nantes, France. FAU - Armand, Stephane AU - Armand S AD - Kinesiology Laboratory, Geneva University Hospitals and University of Geneva, Geneva, Switzerland; Centre of Research on Skeletal Muscle and Movement, Geneva University Hospitals and University of Geneva, Geneva, Switzerland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260307 PL - England TA - Gait Posture JT - Gait & posture JID - 9416830 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology MH - Reproducibility of Results MH - Female MH - Male MH - Adolescent MH - Young Adult MH - *Gait/physiology MH - *Lower Extremity/physiopathology MH - Biomechanical Phenomena MH - Gait Analysis MH - Knee Joint/physiopathology MH - Motion Capture MH - Hip Joint/physiopathology MH - Child MH - Ankle Joint/physiopathology MH - Adult MH - *Gait Disorders, Neurologic/physiopathology/etiology OTO - NOTNLM OT - Continuous Relative Phase OT - Minimal Detectable Change OT - Repeatability OT - Standard Error of Measurement OT - Variability OT - Walking COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/12 01:09 MHDA- 2026/04/13 00:31 CRDT- 2026/03/11 19:09 PHST- 2025/05/13 00:00 [received] PHST- 2026/03/04 00:00 [revised] PHST- 2026/03/05 00:00 [accepted] PHST- 2026/04/13 00:31 [medline] PHST- 2026/03/12 01:09 [pubmed] PHST- 2026/03/11 19:09 [entrez] AID - S0966-6362(26)00056-1 [pii] AID - 10.1016/j.gaitpost.2026.110148 [doi] PST - ppublish SO - Gait Posture. 2026 Jun;127:110148. doi: 10.1016/j.gaitpost.2026.110148. Epub 2026 Mar 7. PMID- 41810520 OWN - NLM STAT- MEDLINE DCOM- 20260618 LR - 20260818 IS - 1552-5732 (Electronic) IS - 0890-3344 (Linking) VI - 42 IP - 2 DP - 2026 May TI - Development and Psychometric Properties of the Breastfeeding Avoidance Scale (BAS). PG - 352-364 LID - 10.1177/08903344261419356 [doi] AB - BACKGROUND: Breastfeeding provides significant benefits for infant health and well-being. However, many mothers develop avoidance behaviors due to the physical, psychological, and sociocultural challenges they encounter during the breastfeeding process. RESEARCH AIM: The purpose of this study was to create and assess the Breastfeeding Avoidance Scale's psychometric features in Turkish postpartum mothers. METHODS: A cross-sectional, methodological, and descriptive design was used to assess 227 postpartum mothers. The Breastfeeding Avoidance Items were developed based on an extensive review of the literature, and include 18 items across two subscales. Reliability was assessed using Cronbach's alpha and test-retest techniques, while validity was assessed using expert feedback and exploratory factor analysis. RESULTS: A two-factor structure that accounted for 63.06% of the variation was found using exploratory and confirmatory factor analysis. A satisfactory model fit was shown by confirmatory factor analysis (chi(2)/df = 2.90, RMSEA = 0.08, CFI = 0.91). Breastfeeding Avoidance Items showed great test-retest reliability (r = 0.82, ICC = 0.861) and excellent internal consistency (Cronbach's alpha = 0.965). Concurrent validity was supported by the finding of a substantial negative correlation (r = -0.743, p < 0.01) between the Breastfeeding Avoidance Items and the Breastfeeding Self-Efficacy Scale. CONCLUSION: The Breastfeeding Avoidance Items is a valid and reliable tool for evaluating Turkish mothers' avoidance of breastfeeding. It offers potential for use in clinical and research settings to identify and address challenges in breastfeeding practices. FAU - Akdag Topal, Cansu AU - Akdag Topal C AUID- ORCID: 0000-0002-1851-1728 AD - Nursing Department, Faculty of Health Sciences, Baskent University, Ankara, Turkiye. FAU - Ercan-Koyuncu, Ilcim AU - Ercan-Koyuncu I AUID- ORCID: 0000-0001-7604-8447 AD - Nursing Department, Faculty of Health Sciences, Baskent University, Ankara, Turkiye. FAU - Kabakci-Saridag, Kubra Nur AU - Kabakci-Saridag KN AUID- ORCID: 0000-0002-2590-2911 AD - Nursing Department, Faculty of Health Sciences, Baskent University, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260311 PL - United States TA - J Hum Lact JT - Journal of human lactation : official journal of International Lactation Consultant Association JID - 8709498 SB - IM MH - Humans MH - *Breast Feeding/psychology MH - Female MH - *Psychometrics/methods/instrumentation/standards MH - Reproducibility of Results MH - Cross-Sectional Studies MH - Adult MH - Surveys and Questionnaires MH - Turkey MH - *Mothers/psychology MH - Factor Analysis, Statistical MH - Young Adult MH - Postpartum Period/psychology OTO - NOTNLM OT - breastfeeding OT - breastfeeding avoidance scale OT - psychometrics OT - reliability OT - validity COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/03/11 06:56 MHDA- 2026/06/18 12:33 CRDT- 2026/03/11 05:52 PHST- 2026/06/18 12:33 [medline] PHST- 2026/03/11 06:56 [pubmed] PHST- 2026/03/11 05:52 [entrez] AID - 10.1177/08903344261419356 [doi] PST - ppublish SO - J Hum Lact. 2026 May;42(2):352-364. doi: 10.1177/08903344261419356. Epub 2026 Mar 11. PMID- 41810191 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260311 LR - 20260813 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 2 DP - 2026 Feb 28 TI - Comparing muscle mass in children with high-risk neuroblastoma using magnetic resonance imaging and bioelectrical impedance analysis. PG - 42 LID - 10.21037/tp-2025-aw-729 [doi] LID - 42 AB - BACKGROUND: Evidence from recent years suggests that bioelectrical impedance analysis (BIA), or BIA-based assessments of muscle mass, are strongly correlated with magnetic resonance imaging (MRI)-based assessments of muscle mass. Nevertheless, no research has examined how the two approaches relate to kids with high-risk neuroblastoma (HR-NBL). This study examined the clinical relevance of BIA-based and MRI-based muscle mass assessment. Before surgery, we computed the relationship between muscle mass measurements made using BIA and MRI in HR-NBL patients. METHODS: We retrospectively collected data for patients aged 3 to 18 years who were newly diagnosed with HR-NBL at the Children's Hospital, Zhejiang University School of Medicine from November 2023 to November 2024. L4 lumbar levels were identified on axial MRI images, and we measured skeletal muscle cross-sectional area. The Multi-Frequency Body Composition Analyzer InBody S10 (Biospace Co., Ltd., Seoul, Korea) was used to estimate skeletal muscle mass (SMM). The analysis included 32 children. RESULTS: The median patient age was 4.8 years (range, 4.03-6.2 years); 56.3% of the patients were boys, and 43.7% were girls. SMM measured by BIA showed a strong positive correlation with MRI-measured SMM in patients (r=0.956, P<0.001). The concordance correlation coefficient for SMM was 0.862, with a 95% confidence interval (CI) of 0.799-0.905. The SMM showed a mean bias of 0.319+/-1.326 kg, indicating that the BIA method overestimated SMM by 0.319 kg compared to MRI. The Bland-Altman analysis suggests that most participants were within the limits of agreement (LoA). Multiple linear regression analysis revealed that weight was a significant predictor of the outcome variable in the models tested. In the multiple regression model, weight (estimate =0.229, P<0.001) was significantly associated with the outcome, and the model explained 78.8% of the variance (R2=0.788). CONCLUSIONS: In conclusion, in monitoring muscle mass in pediatric HR-NBL patients, BIA measurements showed good correlation and agreement with MRI measurements. The multiple linear regression analysis shows that weight is a significant predictor of the difference in muscle mass in human body composition. CI - (c) AME Publishing Company. FAU - Chen, Xia AU - Chen X AD - Department of Clinical Nutrition, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Wang, Jinhu AU - Wang J AD - Department of Surgical Oncology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Zheng, Yi AU - Zheng Y AD - Department of Radiology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Chen, Fei AU - Chen F AD - Department of Clinical Nutrition, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Long, Qi AU - Long Q AD - Department of Clinical Nutrition, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Ma, Ming AU - Ma M AD - Department of Clinical Nutrition, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. LA - eng PT - Journal Article DEP - 20260212 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC12969175 OTO - NOTNLM OT - Neuroblastoma OT - bioelectrical impedance analysis (BIA) OT - magnetic resonance imaging (MRI) OT - skeletal muscle mass (SMM) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2025-aw-729/coif). The authors have no conflicts of interest to declare. EDAT- 2026/03/11 12:12 MHDA- 2026/03/11 12:13 PMCR- 2026/02/28 CRDT- 2026/03/11 05:28 PHST- 2025/10/20 00:00 [received] PHST- 2026/01/12 00:00 [accepted] PHST- 2026/03/11 12:13 [medline] PHST- 2026/03/11 12:12 [pubmed] PHST- 2026/03/11 05:28 [entrez] PHST- 2026/02/28 00:00 [pmc-release] AID - tp-15-02-42 [pii] AID - 10.21037/tp-2025-aw-729 [doi] PST - ppublish SO - Transl Pediatr. 2026 Feb 28;15(2):42. doi: 10.21037/tp-2025-aw-729. Epub 2026 Feb 12. PMID- 41808644 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 2146-8427 (Electronic) IS - 1304-0855 (Linking) VI - 24 IP - 2 DP - 2026 Feb TI - Comparison of Radiation Dose Between Low-Dose Postoperative and Standard-Dose Preoperative Abdominal Computed Tomography in Living Liver Donors. PG - 144-148 LID - 10.6002/ect.2025.0277 [doi] AB - OBJECTIVES: Although contrast-enhanced abdominal computed tomography is frequently used to detect possible postoperative complications in living liver donors, radiation exposure remains a major concern. For this reason, we used low-dose postoperative computed tomography scans. We compared radiation doses of low-dose postoperative computed tomog-raphy with those of standard-dose preoperative computed tomography in living liver donors. MATERIALS AND METHODS: This retrospective study included 80 living liver donors (median age of 28.0 years; 40 male participants) who underwent standard-dose preoperative and low-dose postoperative abdo-minal computed tomography scans between 2023 and 2024. Scanning parameters of tube voltage peak, effective tube current, and rotation time were, respectively, 100 kVp, 200 mA.s, and 0.5 s for preoperative computed tomography and 100 kVp, 40 mA.s, and 0.5 s for low-dose postoperative computed tomography. We compared radiation doses, including dose length product and effective dose, for preoperative versus postoperative portal venous phase abdominal computed tomography scans with paired Wilcoxon signed-rank tests. We assessed correlations between the radiation dose and body mass index with the Spearman correlation coefficient. RESULTS: The median dose length product and effective dose with low-dose postoperative computed tomog-raphy were significantly lower than with standard-dose preoperative computed tomography (72.6 vs 371.0 mGy.cm and 1.1 vs 5.6 mSv, respectively; all P < .001). The dose length product and effective dose of preoperative and postoperative computed tomography scans showed very strong positive correlations with body mass index (rho = 0.919 and 0.909, respectively; all P < .001). In all subgroups based on body mass index, the median dose length product and effective dose of postoperative computed tomog-raphy were significantly lower versus preope-rative computed tomography (all P < .001). CONCLUSIONS: Low-dose postoperative computed tomography scans can significantly reduce radiation dose in living liver donors. FAU - Lee, Sunyoung AU - Lee S AD - >From the Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine,Seoul, Republic of Korea. FAU - Kim, Kyoung Won AU - Kim KW FAU - Kwon, Heon-Ju AU - Kwon HJ FAU - Choi, Sang Hyun AU - Choi SH FAU - Yoon, Young-In AU - Yoon YI FAU - Song, Gi-Won AU - Song GW FAU - Lee, Sung-Gyu AU - Lee SG LA - eng PT - Comparative Study PT - Journal Article PL - Turkey TA - Exp Clin Transplant JT - Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation JID - 101207333 SB - IM MH - Humans MH - *Living Donors MH - Male MH - *Radiation Dosage MH - Retrospective Studies MH - Adult MH - *Liver Transplantation/adverse effects MH - *Tomography, X-Ray Computed/adverse effects MH - Predictive Value of Tests MH - Female MH - *Radiation Exposure/adverse effects/prevention & control MH - Young Adult MH - Risk Factors MH - Middle Aged MH - *Hepatectomy/adverse effects MH - *Radiography, Abdominal/adverse effects MH - Adolescent EDAT- 2026/03/11 06:57 MHDA- 2026/03/11 18:59 CRDT- 2026/03/11 05:04 PHST- 2026/03/11 18:59 [medline] PHST- 2026/03/11 06:57 [pubmed] PHST- 2026/03/11 05:04 [entrez] AID - 10.6002/ect.2025.0277 [doi] PST - ppublish SO - Exp Clin Transplant. 2026 Feb;24(2):144-148. doi: 10.6002/ect.2025.0277. PMID- 41808230 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260612 LR - 20260813 IS - 2056-7529 (Electronic) IS - 2056-7529 (Linking) VI - 12 IP - 1 DP - 2026 Mar 10 TI - Patient involvement in the development of childhood, adolescent and young adult cancer survivorship guidelines: recommendations from EU-CAYAS-NET ambassadors. LID - 10.1186/s40900-026-00855-y [doi] LID - 88 AB - BACKGROUND: Survivors of Childhood, Adolescent, and Young Adult (CAYA) cancer can face long-term health complications due to adverse effects of cancer and its treatment, necessitating lifelong follow-up care. Clinical practice guidelines (CPGs) provide evidence-based recommendations for late effects surveillance. Despite the recognized value of patient involvement, its integration into CPG development remains inconsistent and underexplored. OBJECTIVE: This study aimed to identify effective strategies for integrating patient involvement across all phases of CPG development in CAYA cancer survivorship care. METHODS: This qualitative study consisted of a half-day workshop that was conducted during the European Network of Youth Cancer Survivors (EU-CAYAS-NET) ambassador training event in November 2023 in Vienna, Austria. Forty-nine project ambassadors, all CAYA cancer survivors, participated in presentations and interactive sessions, including breakout discussions and mind-mapping exercises. Data from plenary discussions and mind-maps were analyzed using qualitative content analysis to extract key recommendations and conditions for successful patient involvement in CPG development. RESULTS: Participants formulated 12 recommendations and 11 conditions for effective patient involvement in CPG development, structured across four phases: recruitment, preparation, development, and dissemination. Key areas included clarity, support, collaboration, respect, feasibility, and communication. DISCUSSION: These findings emphasize the need for a systematic approach to patient involvement, ensuring patient representatives are integrated as active stakeholders throughout CPG development, in a role that fits the goal of each guideline. CONCLUSION: This study proposes a structured framework for patient involvement in CAYA cancer survivor CPG development, advocating for continuous patient involvement to enhance guideline quality, adoption, and impact. Future efforts should align with our proposed approach to patient involvement in CPG development to establish standardized practices within existing frameworks. CI - (c) 2026. The Author(s). FAU - Wams, Jikke AU - Wams J AD - Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands. J.Wams-2@prinsesmaximacentrum.nl. FAU - Hartogh, Jaap den AU - Hartogh JD AD - Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands. FAU - Gsell, Hannah AU - Gsell H AD - Childhood Cancer International - Europe, Vienna, Austria. FAU - Schneider, Carina AU - Schneider C AD - Childhood Cancer International - Europe, Vienna, Austria. FAU - Brunmair, Barbara AU - Brunmair B AD - Childhood Cancer International - Europe, Vienna, Austria. FAU - Zettl, Anna AU - Zettl A AD - Childhood Cancer International - Europe, Vienna, Austria. FAU - Tomasikova, Zuzana AU - Tomasikova Z AD - Childhood Cancer International - Europe, Vienna, Austria. FAU - Kienesberger, Anita AU - Kienesberger A AD - Childhood Cancer International - Europe, Vienna, Austria. FAU - Rizvi, Katie AU - Rizvi K AD - Youth Cancer Europe, Cluj-Napoca, Romania. FAU - Totovina, Ana M AU - Totovina AM AD - Youth Cancer Europe, Cluj-Napoca, Romania. FAU - Skinner, Roderick AU - Skinner R AD - Great North Children's Hospital, Royal Victoria Infirmary, Newcastle Upon Tyne, UK. AD - Translational and Clinical Research Institute, Wolfson Childhood Cancer Research Centre, Newcastle Upon Tyne, UK. FAU - Dorsthorst, Jeroen Te AU - Dorsthorst JT AD - PanCare, Bussum, The Netherlands. FAU - der Pal, Helena J H van AU - der Pal HJHV AD - Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands. FAU - Kremer, Leontien C M AU - Kremer LCM AD - Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands. AD - Faculty of Medicine, Utrecht University and Utrecht Medical Centre, Utrecht, The Netherlands. FAU - van Dalen, Elvira C AU - van Dalen EC AD - Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands. FAU - Mulder, Renee L AU - Mulder RL AD - Princess Maxima Center for Pediatric Oncology, Utrecht, the Netherlands. CN - EU-CAYAS-NET ambassadors and consortium LA - eng PT - Journal Article DEP - 20260310 PL - England TA - Res Involv Engagem JT - Research involvement and engagement JID - 101708164 PMC - PMC13255260 OAB - Young people who survive cancer often face health problems later in life because of the cancer or its treatment. To help prevent or manage these problems, experts use clinical practice guidelines, which are documents that explain what follow up care survivors should receive. Although involving (former) patients in developing these guidelines is important, it does not always happen in a structured or meaningful way. In this study, we worked with 49 young cancer survivors from across Europe during a workshop held in Vienna in 2023. Through group discussions and interactive exercises, the participants shared their ideas about how (former) patients should be involved in creating follow up care guidelines. The survivors recommended several ways to improve their involvement. This included being clear about expectations, offering support and training, working together respectfully, and communicating openly. Their suggestions were organized into four steps of guideline development: recruiting patients, preparing them for the process, developing the guidelines together, and sharing the final guidelines widely. Our findings show that young cancer survivors should be treated as active partners throughout the process of developing guidelines for follow up care. Using a structured approach can improve the quality and usefulness of these guidelines. We suggest a structured approach to (former) patient involvement so that it becomes a standard part of guideline development in the future. OABL- eng OTO - NOTNLM OT - Cancer survivorship OT - Childhood adolescent and young adult cancer OT - Clinical practice guidelines OT - Participatory research OT - Patient involvement OT - Patient representatives COIS- Declarations. Ethics statement: Participants were recruited via EU-CAYAS-NET's coordinating organization, Childhood Cancer International Europe (CCI-E), an umbrella organization representing parent and patient advocacy groups. They decided that based on local regulations an ethical review was not needed, because no personal data or medical patient records were accessed, and only the final consensus output from the group was included in this study. Competing interest: The authors declare no competing interests. FIR - Purisevic, Amar IR - Purisevic A FIR - Totovina, Ana IR - Totovina A FIR - Shapiro, Anat IR - Shapiro A FIR - Serafimovska, Andrijana IR - Serafimovska A FIR - Zackova, Aneta IR - Zackova A FIR - Buchacz, Ania IR - Buchacz A FIR - Zettl, Anna IR - Zettl A FIR - Schroeder, Anouk IR - Schroeder A FIR - Moggan, Aoife IR - Moggan A FIR - Kevalaite, Ausrine IR - Kevalaite A FIR - Ristovski, Bojan IR - Ristovski B FIR - Monge-Montero, Carmen IR - Monge-Montero C FIR - Lopes, Carolina IR - Lopes C FIR - Wissmann, Celine IR - Wissmann C FIR - Mathot, Cherine IR - Mathot C FIR - Ryan, Colette IR - Ryan C FIR - Arsenie-Constantinescu, Elena IR - Arsenie-Constantinescu E FIR - Gimzauskaite-Cesleviciene, Emilija IR - Gimzauskaite-Cesleviciene E FIR - Sturesson, Erik IR - Sturesson E FIR - Fletcher, Glenn IR - Fletcher G FIR - Rabin, Hanna IR - Rabin H FIR - Gsell, Hannah IR - Gsell H FIR - Hartogh, Jaap den IR - Hartogh JD FIR - Duikers, Jerome IR - Duikers J FIR - Maldonado, Jorge Alberto Guzman IR - Maldonado JAG FIR - Plavsic, Jovana IR - Plavsic J FIR - Malolli, Ketiona IR - Malolli K FIR - Nikolaisone, Lasma IR - Nikolaisone L FIR - Dorotic, Lucija IR - Dorotic L FIR - Bax, Lyzette Danielle IR - Bax LD FIR - Jaworska, Magdalena IR - Jaworska M FIR - Madan, Maria-Virgilia IR - Madan MV FIR - Gubi, Marie-Therese IR - Gubi MT FIR - Grace-Churchard, Mariosa IR - Grace-Churchard M FIR - Ouren, Martine Kvarstein IR - Ouren MK FIR - Buettner, Maximilian IR - Buettner M FIR - Elizabeth, Mel IR - Elizabeth M FIR - Severinac, Mihael IR - Severinac M FIR - Hrad, Nataliia IR - Hrad N FIR - Unterecker, Nicola IR - Unterecker N FIR - Sousa, Oriana de IR - Sousa O FIR - Lindores, Rebekkah IR - Lindores R FIR - Lassfolk, Sara IR - Lassfolk S FIR - Schippers, Shauny IR - Schippers S FIR - Silva, Sonia IR - Silva S FIR - Costa, Tiago Pinto da IR - Costa TPD FIR - Karaivanova, Vanesa IR - Karaivanova V FIR - Hodzic, Vedad IR - Hodzic V FIR - Tomasikova, Zuzana IR - Tomasikova Z FIR - Kienesberger, Anita IR - Kienesberger A FIR - Rizvi, Katie IR - Rizvi K FIR - Essiaf, Samira IR - Essiaf S FIR - van der Pal, Heleen IR - van der Pal H FIR - Kremer, Leontien IR - Kremer L FIR - Ciakiene, Neringa IR - Ciakiene N FIR - Escalera, Begonya Nafria IR - Escalera BN FIR - Leiss, Ulrike IR - Leiss U FIR - O'Brien, Kylie IR - O'Brien K EDAT- 2026/03/11 06:57 MHDA- 2026/03/11 06:58 PMCR- 2026/03/10 CRDT- 2026/03/11 00:55 PHST- 2025/12/05 00:00 [received] PHST- 2026/02/20 00:00 [accepted] PHST- 2026/03/11 06:58 [medline] PHST- 2026/03/11 06:57 [pubmed] PHST- 2026/03/11 00:55 [entrez] PHST- 2026/03/10 00:00 [pmc-release] AID - 10.1186/s40900-026-00855-y [pii] AID - 855 [pii] AID - 10.1186/s40900-026-00855-y [doi] PST - epublish SO - Res Involv Engagem. 2026 Mar 10;12(1):88. doi: 10.1186/s40900-026-00855-y. PMID- 41807969 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1746-160X (Electronic) IS - 1746-160X (Linking) VI - 22 IP - 1 DP - 2026 Mar 11 TI - Evaluation of cephalometric landmarks using artificial intelligence compared to the manual method. LID - 10.1186/s13005-026-00608-y [doi] LID - 44 AB - BACKGROUND: There is growing interest in cephalometric methods based on artificial intelligence (AI), as they can significantly reduce clinicians' workload and increase productivity. However, the literature indicates that further research is required to bridge the gap between operator-performed and AI-performed cephalometry. The aim of this study was to compare and evaluate the reproducibility and accuracy of three cephalometric methods: Manual, WebCeph and AngelAligner. METHODS: Thirty cephalograms from 30 patients (50% male, 50% female) were analyzed. Thirty-five landmarks were recorded using three different methodologies (Manual, WebCeph, and AngelAligner) at two time points (T1 and T2). RESULTS: The method with the highest number of cephalometric landmarks showing an excellent successful detection rate (SDR) was the manual method, in which 18 of the 35 points demonstrated an SDR < 1 mm in 80% of the analyzed cephalograms, thus being the most accurate. However, greater T1-T2 variations were observed with the manual method. The AI methods showed high and statistically significant correlations for all landmarks (p < 0.01), except for Pg'. The manual method showed low and non-significant correlations for all points except Na' (p < 0.05) and UL (p < 0.01). CONCLUSIONS: Fully automated, AI-based cephalometric methods are more reproducible than manual methods. In terms of accuracy, certain AI-based point detections may be comparable to those of an expert, although supervision remains necessary to ensure precise and reliable results. FAU - Alvarado-Lorenzo, Alfonso AU - Alvarado-Lorenzo A AD - Department of Oral Surgery, Universidad de Salamanca, Salamanca, 37007, Spain. FAU - Criado-Perez, Laura AU - Criado-Perez L AD - Department of Oral Surgery, Universidad de Salamanca, Salamanca, 37007, Spain. lauracriado@usal.es. FAU - Garcovich, Daniele AU - Garcovich D AD - Department of Dentistry, Universidad Europea de Valencia, Valencia, 46010, Spain. FAU - Romero, Sabina AU - Romero S AD - Department of Oral Surgery, Universidad de Salamanca, Salamanca, 37007, Spain. FAU - Scuzzo, Giuseppe AU - Scuzzo G AD - Department of Orthodontics, Universita Cattolica del Sacro Cuore, Largo Francesco Vito, 1, Rome, 00168, Italy. FAU - Scuzzo, Giacomo AU - Scuzzo G AD - Eline Clinic Director, Piazza Gregorio Ronca, 38, Rome, 00122, Italy. FAU - Jorba-Garcia, Adria AU - Jorba-Garcia A AD - Department of Oral Surgery and Implantology, Faculty of Medicine and Health Sciences, University of Barcelona, Barcelona, 08907, Spain. FAU - Curto, Adrian AU - Curto A AD - Department of Oral Surgery, Universidad de Salamanca, Salamanca, 37007, Spain. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260311 PL - England TA - Head Face Med JT - Head & face medicine JID - 101245792 SB - IM MH - Humans MH - *Cephalometry/methods MH - Female MH - Reproducibility of Results MH - Male MH - *Artificial Intelligence MH - *Anatomic Landmarks MH - Adolescent PMC - PMC13088742 OTO - NOTNLM OT - Artificial intelligence OT - Cephalometric analysis OT - Digital tracing OT - Manual tracing OT - Orthodontics OT - Treatment planning COIS- Declarations. Ethics approval and consent to participate: The protocol for all procedures adhered to the basic principles of the Declaration of Helsinki and Organic Law 3/2018 of December 5, on the Protection of Personal Data and the Guarantee of Digital Rights, and was approved by the ethics committee of University of Salamanca (cod:1074/2023). Participants received an informative document detailing the description and purpose of the study, along with an informed consent form, which they were required to sign to be included as participants. Consent for publication: Consent for publication was obtained from all subjects involved in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/03/11 06:57 MHDA- 2026/06/28 00:36 PMCR- 2026/03/11 CRDT- 2026/03/11 00:40 PHST- 2025/07/02 00:00 [received] PHST- 2026/03/04 00:00 [accepted] PHST- 2026/06/28 00:36 [medline] PHST- 2026/03/11 06:57 [pubmed] PHST- 2026/03/11 00:40 [entrez] PHST- 2026/03/11 00:00 [pmc-release] AID - 10.1186/s13005-026-00608-y [pii] AID - 608 [pii] AID - 10.1186/s13005-026-00608-y [doi] PST - epublish SO - Head Face Med. 2026 Mar 11;22(1):44. doi: 10.1186/s13005-026-00608-y. PMID- 41807417 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2052-4463 (Electronic) IS - 2052-4463 (Linking) VI - 13 IP - 1 DP - 2026 Mar 11 TI - A hand biomechanics dataset of kinematics, kinetics, electromyography, and imaging in healthy adults. LID - 10.1038/s41597-026-06939-4 [doi] LID - 646 AB - Developing musculoskeletal hand models requires a variety of experimental biomechanics data. However, collecting robust biomechanics hand data is a time intensive process leading to a lack of widely available datasets. To address this issue the biomechanics hand modeling database (BHaM) was made as a collection of experimental data to aid the development, testing, and validation of musculoskeletal models and simulations. BHaM includes two datasets: (1) a population dataset (n = 726 adults) describing hand strength (pinch and grip), self-reported hand function (Michigan Hand Questionnaire), and anthropometric measurements (from photographs), and (2) a biomechanics dataset (n = 30 adults) describing kinematics (marker-based motion capture), kinetics (isometric and isokinetic data), and electromyography (surface and fine wire) during 19 tasks across the elbow, wrist, and hand. A subset of the biomechanics dataset (n = 15 adults) also includes magnetic resonance imaging of the shoulder through wrist. Participants for both datasets were recruited to represent a diverse population of healthy adults, ranging from 18 to 91 years. CI - (c) 2026. The Author(s). FAU - Diaz, Maximillian T AU - Diaz MT AD - J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. FAU - Benoit, Alexis R AU - Benoit AR AD - J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. FAU - Kearney, Kalyn M AU - Kearney KM AD - J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. FAU - Kelly, Troy F Jr AU - Kelly TF Jr AD - J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. FAU - Lindbeck, Erica M AU - Lindbeck EM AD - Department of Electrical & Computer Engineering, University of Florida, Gainesville, FL, USA. FAU - Tappan, Isaly AU - Tappan I AD - Department of Electrical & Computer Engineering, University of Florida, Gainesville, FL, USA. FAU - Bowers, William S AU - Bowers WS AD - J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. FAU - Durai, Lavanya AU - Durai L AD - J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. FAU - Nunag, Justin B AU - Nunag JB AD - J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. FAU - Officer, Michael B AU - Officer MB AD - J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. FAU - Harley, Joel B AU - Harley JB AD - Department of Electrical & Computer Engineering, University of Florida, Gainesville, FL, USA. FAU - Nichols, Jennifer A AU - Nichols JA AD - J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida, Gainesville, FL, USA. jnichols@bme.ufl.edu. LA - eng PT - Dataset PT - Journal Article DEP - 20260311 PL - England TA - Sci Data JT - Scientific data JID - 101640192 SB - IM UOF - bioRxiv. 2025 Aug 25:2025.08.21.671503. doi: 10.1101/2025.08.21.671503. PMID: 40909532 MH - Humans MH - Electromyography MH - Adult MH - Biomechanical Phenomena MH - *Hand/physiology/diagnostic imaging MH - Middle Aged MH - Aged MH - Young Adult MH - Adolescent MH - Aged, 80 and over MH - Female MH - Motion Capture MH - Magnetic Resonance Imaging MH - Hand Strength MH - Kinetics MH - Male PMC - PMC13111597 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/03/11 06:56 MHDA- 2026/04/27 00:30 PMCR- 2026/03/11 CRDT- 2026/03/11 00:17 PHST- 2025/08/26 00:00 [received] PHST- 2026/02/19 00:00 [accepted] PHST- 2026/04/27 00:30 [medline] PHST- 2026/03/11 06:56 [pubmed] PHST- 2026/03/11 00:17 [entrez] PHST- 2026/03/11 00:00 [pmc-release] AID - 10.1038/s41597-026-06939-4 [pii] AID - 6939 [pii] AID - 10.1038/s41597-026-06939-4 [doi] PST - epublish SO - Sci Data. 2026 Mar 11;13(1):646. doi: 10.1038/s41597-026-06939-4. PMID- 41807323 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 1876-4479 (Electronic) IS - 1873-9946 (Linking) VI - 20 IP - 3 DP - 2026 Mar 10 TI - Patient knowledge and awareness on inflammatory bowel disease as it evolves as a global disease: a scoping review. LID - jjag019 [pii] LID - 10.1093/ecco-jcc/jjag019 [doi] AB - BACKGROUND: Patient knowledge is pivotal to inflammatory bowel disease (IBD) management, yet educational opportunities vary widely worldwide. This scoping review maps existing evidence on patient knowledge, explores regional and demographic differences, and identifies gaps to guide culturally adaptable interventions. METHODS: Following PRISMA-ScR guidelines, PubMed and Embase were searched up to December 31, 2025, for studies assessing patient knowledge in IBD. Eligible adult and pediatric studies were independently screened and synthesized by two reviewers across key knowledge domains, including disease basics, treatment, complications, colorectal cancer (CRC) risk, surgery, vaccination, and diet. RESULTS: From 8464 records, 53 studies met inclusion criteria. Validated tools, including CCKNOW and IBD-KNOW, predominated in adult studies, whereas IBD-KID and IBD-KID2 were used in pediatric populations. Knowledge levels varied widely: correct understanding of anatomy (36%-68%), risk factors (16%-85%), CRC risk (24%-78%), and surgery (13%-16%) was frequently suboptimal. Only 5%-51% recognized azathioprine as an immunosuppressant. Awareness of vaccination (39%-78%) and dietary relevance (23%-65%) remained limited. Gastroenterologists were the primary information source (42%-96%). Higher knowledge was associated with both sociodemographic factors (female sex, younger age, higher educational attainment) and disease-related characteristics (longer disease duration, prior exposure to biologics or surgery, Crohn's disease phenotype). Patients in Europe and North America had higher awareness than those in Asia and the Middle East, probably due to better healthcare access and patient education infrastructure. CONCLUSIONS: Global IBD knowledge and awareness remain inadequate and uneven across regions and domains. Updated, culturally appropriate and adaptable assessment tools and multidisciplinary, technology-enabled educational strategies are needed to enhance IBD literacy. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of European Crohn's and Colitis Organisation. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Singh, Arshdeep AU - Singh A AUID- ORCID: 0000-0001-7163-0454 AD - Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India. FAU - Bhardwaj, Arshia AU - Bhardwaj A AD - Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India. FAU - Jena, Anuraag AU - Jena A AD - Department of Gastroenterology, Institute of Medical Sciences and SUM Hospital, Bhubaneswar, Odisha, India. FAU - Midha, Vandana AU - Midha V AD - Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India. FAU - Sood, Ajit AU - Sood A AUID- ORCID: 0000-0001-6961-6389 AD - Department of Gastroenterology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India. FAU - Sharma, Vishal AU - Sharma V AUID- ORCID: 0000-0003-2472-3409 AD - Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, Punjab, India. FAU - Sebastian, Shaji AU - Sebastian S AUID- ORCID: 0000-0002-3670-6545 AD - Department of Gastroenterology, IBD Unit, Hull University Teaching Hospitals, Hull, United Kingdom. LA - eng PT - Journal Article PT - Scoping Review PL - England TA - J Crohns Colitis JT - Journal of Crohn's & colitis JID - 101318676 SB - IM MH - Humans MH - *Inflammatory Bowel Diseases/therapy/psychology MH - *Health Knowledge, Attitudes, Practice MH - Global Health MH - Patient Education as Topic MH - Risk Factors OTO - NOTNLM OT - Crohn's disease OT - colitis OT - educational measurement OT - geographic locations OT - literacy OT - ulcerative EDAT- 2026/03/11 06:55 MHDA- 2026/03/11 18:59 CRDT- 2026/03/11 00:04 PHST- 2026/03/11 18:59 [medline] PHST- 2026/03/11 06:55 [pubmed] PHST- 2026/03/11 00:04 [entrez] AID - 8513172 [pii] AID - 10.1093/ecco-jcc/jjag019 [doi] PST - ppublish SO - J Crohns Colitis. 2026 Mar 10;20(3):jjag019. doi: 10.1093/ecco-jcc/jjag019. PMID- 41807273 OWN - NLM STAT- MEDLINE DCOM- 20260311 LR - 20260813 IS - 1365-277X (Electronic) IS - 0952-3871 (Print) IS - 0952-3871 (Linking) VI - 39 IP - 2 DP - 2026 Apr TI - Psychometric Properties and Gender-Based Assessment of the Florence Emotional Eating Drive (FEED) in Brazilians. PG - e70229 LID - 10.1111/jhn.70229 [doi] LID - e70229 AB - BACKGROUND: Emotional eating, defined as eating influenced by emotional states, has been linked to the development of chronic diseases. Psychometric instruments, such as the Florence Emotional Eating Drive (FEED), are crucial for screening this behaviour, and their relevance must be validated in Brazil. This study aimed to evaluate the psychometric properties of the FEED in Brazilians and to examine gender-based differences in emotional eating drive. METHODS: This cross-sectional study collected data online. The FEED originally comprises 23 items and three factors. Factorial, convergent, discriminant, and concurrent validity, as well as reliability, were analysed separately for each gender. Different factorial models of the FEED were tested, and refinement of a model previously applied in Brazil was required for both genders. FEED scores were computed, classified into categories, and compared between genders. RESULTS: A total of 1274 individuals (54.6% men) aged >/= 18 years participated. A 21-item model with three factors (Brazilian refined version) demonstrated good psychometric properties for both men and women. A second-order hierarchical model based on this structure was parsimonious and enabled the computation of a global emotional eating score. Significant gender differences emerged, with women presenting higher emotional eating scores. Most participants were classified as having no or low emotional urge to eat, with a higher prevalence among men. CONCLUSIONS: The FEED proved psychometrically robust for Brazilian women and men after item reduction. Gender-based differences indicate greater emotional eating among women, reinforcing the importance of considering gender-specific aspects in research and interventions addressing this construct. CI - (c) 2026 The Author(s). Journal of Human Nutrition and Dietetics published by John Wiley & Sons Ltd on behalf of British Dietetic Association. FAU - Guareschi, Carla Goncalves AU - Guareschi CG AUID- ORCID: 0009-0004-1235-9923 AD - Postgraduate Program in Food, Nutrition and Food Engineering, Sao Paulo State University (UNESP), Araraquara, SP, Brazil. FAU - Neves, Angela Nogueira AU - Neves AN AUID- ORCID: 0000-0001-8304-1040 AD - Postgraduate Program in International Security and Defense, Army Physical Education School, Superior War College, Rio de Janeiro, RJ, Brazil. FAU - Silva, Wanderson Roberto da AU - Silva WRD AUID- ORCID: 0000-0001-8897-8772 AD - Postgraduate Program in Food, Nutrition and Food Engineering, Sao Paulo State University (UNESP), Araraquara, SP, Brazil. AD - Centro Universitario de Patos de Minas (UNIPAM), Patos de Minas, Minas Gerais, Brazil. LA - eng GR - 001/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ PT - Journal Article PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 RN - Brazilian people SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Brazil MH - Cross-Sectional Studies MH - *Emotional Eating/psychology MH - *Emotions MH - *Psychometrics MH - Reproducibility of Results MH - Sex Factors MH - Surveys and Questionnaires MH - South American People PMC - PMC12975697 OTO - NOTNLM OT - drive OT - emotional eating OT - gender OT - psychometrics OT - questionnaire COIS- The authors declare no conflicts of interest. EDAT- 2026/03/11 01:12 MHDA- 2026/03/11 13:20 PMCR- 2026/03/11 CRDT- 2026/03/10 23:22 PHST- 2026/01/07 00:00 [revised] PHST- 2025/10/16 00:00 [received] PHST- 2026/03/03 00:00 [accepted] PHST- 2026/03/11 13:20 [medline] PHST- 2026/03/11 01:12 [pubmed] PHST- 2026/03/10 23:22 [entrez] PHST- 2026/03/11 00:00 [pmc-release] AID - JHN70229 [pii] AID - 10.1111/jhn.70229 [doi] PST - ppublish SO - J Hum Nutr Diet. 2026 Apr;39(2):e70229. doi: 10.1111/jhn.70229. PMID- 41807093 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20261016 IS - 2047-6310 (Electronic) IS - 2047-6302 (Print) IS - 2047-6302 (Linking) VI - 21 IP - 3 DP - 2026 Mar TI - Validity of the PortionSize App for Assessing Children's Dietary Intake: Results From a Pilot Study Conducted in Controlled and Free-Living Settings. PG - e70102 LID - 10.1111/ijpo.70102 [doi] AB - BACKGROUND: PortionSize is a mobile app that allows users to assess dietary intake and provide feedback in real-time. OBJECTIVE: To assess the validity of the PortionSize app for estimating children's dietary intake when assessed by the children themselves (phase 1) and relative agreement of the app when assessed by their parents (phase 2). METHODS: This pilot study recruited 31 child/parent dyads. Each dyad was trained on the PortionSize app to assess dietary intake. In phase 1, children (7-12 years) assessed dietary intake in a controlled setting, and their assessments were compared with weighed meals. In phase 2, parents assessed their child's dietary intake in a free-living setting, and the criterion measure was the digital photography of foods (DPF) method. RESULTS: Children's energy intake assessments using PortionSize were equivalent to weighed meals (p < 0.05, effect size: 0.22), while energy intake estimates by parents using PortionSize were not equivalent to the DPF method (p > 0.05, effect size: 0.26). The mean percent error between the measurements was 9.1% in phase 1 and 16.5% in phase 2. CONCLUSIONS: The findings suggest PortionSize may be accurate in controlled settings when used by children. In a free-living setting when used by parents, results indicated PortionSize needs improvements in methods for estimating portion size and food identification. The study findings from phase 2 reflect feasibility and relative agreement rather than validation against true intake. This pilot study focuses on initial validity, relative agreement, and user satisfaction, indicating potential for future clinical and community-based pediatric dietary and weight management applications. TRIAL REGISTRATION: NCT05587816 (https://clinicaltrials.gov/study/NCT05587816?term=PortionSize%20app&rank=1). CI - (c) 2026 World Obesity Federation. FAU - Saha, Sanjoy AU - Saha S AUID- ORCID: 0000-0003-0253-8181 AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. AD - Tennessee State University, Nashville, Tennessee, USA. FAU - Diktas, Hanim E AU - Diktas HE AUID- ORCID: 0000-0002-4603-3719 AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. FAU - Lozano, Chloe P AU - Lozano CP AUID- ORCID: 0000-0003-4278-1602 AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. AD - University of Hawaii, Cancer Center, Honolulu, Hawaii, USA. FAU - Staiano, Amanda E AU - Staiano AE AUID- ORCID: 0000-0001-7846-046X AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. FAU - Broyles, Stephanie T AU - Broyles ST AUID- ORCID: 0000-0003-3168-0056 AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. FAU - Apolzan, John W AU - Apolzan JW AUID- ORCID: 0000-0001-8492-7820 AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. FAU - Martin, Corby K AU - Martin CK AUID- ORCID: 0000-0002-8125-4015 AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. LA - eng SI - ClinicalTrials.gov/NCT05587816 GR - 2022-09708/National Institute of Food and Agriculture/ GR - F32 HD116537/HD/NICHD NIH HHS/United States GR - P30 DK072476/DK/NIDDK NIH HHS/United States GR - U54 GM104940/GM/NIGMS NIH HHS/United States GR - NH/NIH HHS/United States GR - P50 MD017338/MD/NIMHD NIH HHS/United States GR - Blue Cross and Blue Shield of Louisiana Foundation/ GR - Eunice Kennedy Shriver National Institute of Child Health and Human Development/ GR - R01 DK124558/DK/NIDDK NIH HHS/United States PT - Clinical Study PT - Journal Article PT - Validation Study PL - England TA - Pediatr Obes JT - Pediatric obesity JID - 101572033 SB - IM MH - Child MH - Female MH - Humans MH - Male MH - *Energy Intake MH - Feeding Behavior MH - *Mobile Applications MH - Nutrition Assessment MH - Parents MH - Pilot Projects MH - *Portion Size MH - Reproducibility of Results PMC - PMC13077788 MID - NIHMS2162283 OTO - NOTNLM OT - MyPlate OT - energy intake OT - food groups OT - food intake OT - food photography OT - paediatrics OT - portion size COIS- CONFLICT OF INTEREST STATEMENT Louisiana State University and Pennington Biomedical Research Center own the intellectual property associated with the PortionSize app. Authors CKM and JWA, who are employed by these institutions, are the inventors of the technology. EDAT- 2026/03/11 01:11 MHDA- 2026/03/11 19:00 PMCR- 2026/04/14 CRDT- 2026/03/10 21:54 PHST- 2026/03/01 00:00 [revised] PHST- 2025/05/01 00:00 [received] PHST- 2026/03/03 00:00 [accepted] PHST- 2026/03/11 19:00 [medline] PHST- 2026/03/11 01:11 [pubmed] PHST- 2026/03/10 21:54 [entrez] PHST- 2026/04/14 00:00 [pmc-release] AID - 10.1111/ijpo.70102 [doi] PST - ppublish SO - Pediatr Obes. 2026 Mar;21(3):e70102. doi: 10.1111/ijpo.70102. PMID- 41806387 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 1465-735X (Electronic) IS - 0146-8693 (Print) IS - 0146-8693 (Linking) VI - 51 IP - 5 DP - 2026 May 1 TI - Predictive utility and cut point of the Physical Activity Questionnaire-Children for differentiating youth meeting moderate to vigorous physical activity recommendations using accelerometry. PG - 405-411 LID - 10.1093/jpepsy/jsaf116 [doi] AB - OBJECTIVE: Moderate-to-vigorous physical activity (MVPA) is associated with a host of health benefits. As researchers continue to develop an understanding of what keeps young people from meeting physical activity recommendations, there is a need to develop efficient and cost-effective measures that can accurately distinguish youth who meet guidelines from those who do not. Therefore, the current study aims to evaluate the utility of the Physical Activity Questionnaire for Children (PAQ-C) in predicting accelerometer-derived estimates of MVPA. METHOD: The final sample included 184 youth between the ages of 8 and 12 years, who completed self-report measures and wore an accelerometer for two weeks. Binary logistic regression was performed to evaluate the relationship between PAQ-C composite score and MVPA recommendation status. Receiver operating characteristic analysis was performed to identify an optimal cut value for the PAQ-C. RESULTS: Age and gender demonstrated small, but significant associations with meeting MVPA recommendation status. Specifically, females and older participants were less likely to meet MVPA recommendations. PAQ-C was also identified as a significant predictor of youth meeting MVPA recommendation status. The area under the curve was found to be .76. A cut value of 3.34 was found to optimize both specificity (.70) and sensitivity (.76). Participants at or above this value can be classified as having met MVPA recommendations. CONCLUSIONS: The PAQ-C was found to be a useful measure for predicting youth meeting MVPA recommendations. Researchers can use these findings to determine if participants are meeting MVPA recommendations of 60 or more minutes of MVPA per day by evaluating if participants meet or exceed the identified PAQ-C cut point. Future studies should continue to establish the predicative utility of the PAQ-C for youth experiencing chronic health conditions, such as obesity. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Hefner, Tristen AU - Hefner T AUID- ORCID: 0000-0002-0324-6036 AD - Clinical Psychology Program, Texas Tech University, Lubbock, TX, United States. FAU - Halbreich, Eli AU - Halbreich E AUID- ORCID: 0000-0003-4942-9804 AD - Clinical Psychology Program, Texas Tech University, Lubbock, TX, United States. FAU - Van Allen, Jason AU - Van Allen J AUID- ORCID: 0000-0002-9228-3815 AD - Clinical Psychology Program, Texas Tech University, Lubbock, TX, United States. LA - eng GR - R03HD095218/Eunice Kennedy Striver National Institute of Child Health and Human Development of the National Institutes of Health/ GR - Eunice Kennedy Striver National Institute of Child Health and Human Development/ GR - R03HD095218/NH/NIH HHS/United States PT - Journal Article PL - United States TA - J Pediatr Psychol JT - Journal of pediatric psychology JID - 7801773 SB - IM MH - Humans MH - Child MH - Female MH - *Exercise/physiology MH - *Accelerometry MH - Male MH - Surveys and Questionnaires/standards PMC - PMC13221184 OTO - NOTNLM OT - health behavior OT - measure development and validation OT - school-age children OT - statistical approach COIS- None of the authors has any competing interests or financial interests to disclose. EDAT- 2026/03/11 01:11 MHDA- 2026/05/30 00:33 PMCR- 2027/03/10 CRDT- 2026/03/10 18:44 PHST- 2025/05/14 00:00 [received] PHST- 2025/12/05 00:00 [revised] PHST- 2025/12/19 00:00 [accepted] PHST- 2026/05/30 00:33 [medline] PHST- 2026/03/11 01:11 [pubmed] PHST- 2026/03/10 18:44 [entrez] PHST- 2027/03/10 00:00 [pmc-release] AID - 8513049 [pii] AID - jsaf116 [pii] AID - 10.1093/jpepsy/jsaf116 [doi] PST - ppublish SO - J Pediatr Psychol. 2026 May 1;51(5):405-411. doi: 10.1093/jpepsy/jsaf116. PMID- 41806132 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260920 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 3 DP - 2026 Mar 10 TI - The role of the FT3/FT4 ratio in predicting remission and relapse in pediatric Graves' disease. LID - 10.1007/s00431-026-06808-7 [doi] LID - 172 AB - Long-term antithyroid drug (ATD) therapy is often required in pediatric Graves' disease, yet adherence can be challenging. Therefore, identifying reliable predictors of remission and relapse is crucial for optimizing disease management. This study aimed to evaluate the role of the baseline FT3/FT4 ratio in predicting remission and relapse, alongside other potential markers, including TRAb levels, thyroid volume, and body mass index (BMI). This retrospective, single-center study included pediatric patients diagnosed with Graves' disease and treated with ATDs. Age, sex, BMI, thyroid volume, TRAb, FT3, and FT4 levels were recorded at diagnosis, and the FT3/FT4 ratio was calculated. Remission was defined as maintaining euthyroidism for at least 12 months after discontinuation of ATD therapy, whereas relapse was defined as the recurrence of hyperthyroidism following remission. A total of 55 patients were evaluated. The remission rate was 43.6%, and among those who achieved remission, the relapse rate was 8.3%. No significant association was found between remission and age, sex, BMI, ATD duration, or the FT3/FT4 ratio. However, remission was significantly more likely in patients with TRAb levels < 10 IU/L (p < 0.05). Additionally, an inverse relationship was observed between thyroid volume and the likelihood of remission. Although the baseline FT3/FT4 ratio did not predict remission, it was significantly higher in patients who experienced relapse. An FT3/FT4 ratio > 0.54 pmol/pmol predicted relapse with 75% sensitivity and 98% specificity (AUC = 0.842; p = 0.048). CONCLUSION: The baseline FT3/FT4 ratio demonstrated limited value in predicting remission but proved to be a strong indicator of relapse risk in pediatric Graves' disease. Additionally, lower TRAb levels (< 10 IU/L) and smaller thyroid volumes were associated with higher remission rates. Together, these findings suggest that incorporating the FT3/FT4 ratio, TRAb levels, and thyroid volume into routine assessment may enhance risk stratification and support more personalized treatment approaches for pediatric Graves' disease. WHAT IS KNOWN: * Pediatric Graves' disease often requires long-term antithyroid drug therapy, and remission rates are variable; TRAb levels and thyroid volume are recognized predictors of remission. WHAT IS NEW: * The baseline FT3/FT4 ratio has limited value in predicting remission but may serve as a strong predictor of relapse, with a ratio 0.54 pmol/pmol showing high specifi city for relapse in pediatric Graves' disease. CI - (c) 2026. The Author(s). FAU - Kara, Leyla AU - Kara L AUID- ORCID: 0000-0002-5261-9222 AD - Department of Pediatric Endocrinology, Erciyes University Faculty of Medicine Hospitals, Kayseri, Turkey. FAU - Siraz, Ulku Gul AU - Siraz UG AUID- ORCID: 0000-0001-7708-3498 AD - Department of Pediatric Endocrinology, Erciyes University Faculty of Medicine Hospitals, Kayseri, Turkey. FAU - Cicek, Dilek AU - Cicek D AUID- ORCID: 0000-0001-5652-1401 AD - Department of Pediatric Endocrinology, Erciyes University Faculty of Medicine Hospitals, Kayseri, Turkey. FAU - Sarikaya, Emre AU - Sarikaya E AUID- ORCID: 0000-0002-7355-5408 AD - Department of Pediatric Endocrinology, Erciyes University Faculty of Medicine Hospitals, Kayseri, Turkey. FAU - Gok, Ebru AU - Gok E AUID- ORCID: 0000-0001-7655-2301 AD - Department of Pediatric Endocrinology, Erciyes University Faculty of Medicine Hospitals, Kayseri, Turkey. FAU - Berber, Ugur AU - Berber U AUID- ORCID: 0000-0001-6271-5317 AD - Department of Pediatric Endocrinology, Erciyes University Faculty of Medicine Hospitals, Kayseri, Turkey. FAU - Kendirci, Mustafa AU - Kendirci M AUID- ORCID: 0000-0002-2100-3628 AD - Department of Pediatric Endocrinology, Erciyes University Faculty of Medicine Hospitals, Kayseri, Turkey. FAU - Kurtoglu, Selim AU - Kurtoglu S AUID- ORCID: 0000-0002-5256-0128 AD - Department of Pediatric Endocrinology, Erciyes University Faculty of Medicine Hospitals, Kayseri, Turkey. FAU - Hatipoglu, Nihal AU - Hatipoglu N AUID- ORCID: 0000-0002-0991-6539 AD - Department of Pediatric Endocrinology, Erciyes University Faculty of Medicine Hospitals, Kayseri, Turkey. nhatipoglu@erciyes.edu.tr. LA - eng PT - Journal Article DEP - 20260310 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 0 (Antithyroid Agents) RN - Q51BO43MG4 (Thyroxine) RN - 06LU7C9H1V (Triiodothyronine) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Graves Disease/drug therapy/blood/diagnosis MH - Female MH - Retrospective Studies MH - Recurrence MH - Child MH - *Antithyroid Agents/therapeutic use MH - *Thyroxine/blood MH - Male MH - Remission Induction MH - *Triiodothyronine/blood MH - Adolescent MH - Biomarkers/blood MH - Predictive Value of Tests MH - Thyroid Gland/pathology MH - Thyroid Function Tests MH - Body Mass Index PMC - PMC12975841 OTO - NOTNLM OT - Antithyroid drugs OT - FT3/FT4 ratio OT - Graves' disease OT - Hyperthyroidism OT - Relapse OT - Remission OT - Thyrotropin receptor antibodies (TRAb) COIS- Declarations. Ethics approval: This study was conducted in accordance with the Declaration of Helsinki. Approval was obtained from the Erciyes University Clinical Research Ethics Committee approval number 2022/629, 14.09.2022. Competing interests: The authors declare no competing interests. EDAT- 2026/03/10 18:37 MHDA- 2026/03/11 13:20 PMCR- 2026/03/10 CRDT- 2026/03/10 17:29 PHST- 2025/11/23 00:00 [received] PHST- 2026/02/13 00:00 [accepted] PHST- 2026/02/06 00:00 [revised] PHST- 2026/03/11 13:20 [medline] PHST- 2026/03/10 18:37 [pubmed] PHST- 2026/03/10 17:29 [entrez] PHST- 2026/03/10 00:00 [pmc-release] AID - 10.1007/s00431-026-06808-7 [pii] AID - 6808 [pii] AID - 10.1007/s00431-026-06808-7 [doi] PST - epublish SO - Eur J Pediatr. 2026 Mar 10;185(3):172. doi: 10.1007/s00431-026-06808-7. PMID- 41805224 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260805 IS - 1460-2210 (Electronic) IS - 0141-5387 (Linking) VI - 48 IP - 2 DP - 2026 Feb 18 TI - Effectiveness of self-ligating versus conventional brackets for treatment of bimaxillary protrusion: a single-centre randomized clinical trial. LID - cjag013 [pii] LID - 10.1093/ejo/cjag013 [doi] AB - OBJECTIVE: To compare treatment duration between self-ligating and conventional brackets, determine factors influencing treatment duration and compare the quality of orthodontic care with both bracket systems in a bimaxillary protrusion population. SUBJECTS AND METHODS: Participants were randomly allocated into the Smart Clip self-ligation bracket group or the Victory Series conventional ligation bracket group, both with MBT prescription (3M-Unitek, Monrovia, California, USA). Both extraction and nonextraction cases were included. Primary outcome measures included (i) overall treatment duration, (ii) levelling and aligning duration, (iii) Space closure and finishing duration, and (iv) number of appointments and other treatment related factors. The secondary outcomes assessed the quality of care. These occlusal outcomes included incisor inclination, ABO CR-EVAL, patient perception using the Index of Treatment Need and three validated questionnaires before, during and after treatment, measuring patient satisfaction with treatment and patient experience. Independent sample t-test and chi-square tests were conducted to assess differences in groups. Descriptive statistics and parametric tests were conducted. Also, nonparametric tests were carried out where appropriate. This clinical trial was ongoing during the COVID-19 pandemic, therefore, the effect of the pandemic on the trial was also assessed. RESULTS: A total of 109 participants were enrolled. They were randomized in a 1:1 ratio; 13 were excluded (poor attendance prior to and poor attendance due to the COVID-19 pandemic). Forty-nine participants were analysed in the conventional bracket group and 47 in the self-ligating group. The overall mean age was 13 years. The groups were similar pre-treatment, and no statistical significance was found between the groups for treatment duration, duration of key stages and number of appointments (P > 0.05). The mean duration of treatment was 24.34 months for the conventional bracket group and 25.83 months for the self-ligating bracket group. ABO CR-EVAL showed a better quality of finish in the self-ligating bracket group. This, however, was not significant statistically. In both the conventional and self-ligating groups, the post-treatment U1-PP and L1-MP angles were consistent with the reported norms for this population. In extraction and nonextraction cases the self-ligating bracket retroclined the upper (9.2 degrees in extraction and 2.2 degrees in nonextraction cases) and lower incisors (7.3 degrees in extraction and 3.9 degrees in nonextraction cases) more than conventional bracket. In nonextraction cases these differences were not statistically significant (P > 0.05). Pre to post-treatment, there was a highly statistically significant improvement in the IOTN aesthetic component in both groups (P < 0.01).There was a significant difference between groups for pre-IOTN aesthetic assessment. The COVID-19 pandemic had no statistically significant impact on the overall treatment duration. However, it did have an effect on the collection and analysis of some data, with no overall effect on the majority of outcomes assessed in the trial. It was not possible to blind the operator or participants to the allocation. CONCLUSIONS: Use of Smart Clip self-ligating bracket does not reduce overall treatment time in bimaxillary protrusive patients. There were fewer total visits in the self-ligating bracket group when compared with the conventionally ligated bracket group. There is no evidence to suggest a difference in the quality of care or patient experience between self-ligating and conventional bracket systems in a bimaxillary protrusive population. The COVID-19 pandemic did not affect treatment duration. REGISTRATION: The trial was registered with ClinicalTrials.gov on 26th June 2019. Registration number NCT04001816. PROTOCOL: The protocol was not published before trial commencement. FUNDING: The trial was funded by grants from The University ofThe West Indies ( CRP.3.MAR14.3, CRP.3.MAR14.3(1), CRP.3.MAR 14.3(4))andproduct donations from 3M Unitek. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the European Orthodontic Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Hoyte, Trudee AU - Hoyte T AD - Orthodontic Department, School of Dentistry, Faculty of Medical Sciences, University of the West Indies, St. Augustine, Trinidad. FAU - Ali, Anil AU - Ali A AD - Orthodontic Department, School of Dentistry, Faculty of Medical Sciences, University of the West Indies, St. Augustine, Trinidad. FAU - James, Akini AU - James A AD - Orthodontic Department, School of Dentistry, Faculty of Medical Sciences, University of the West Indies, St. Augustine, Trinidad. FAU - Bearn, David AU - Bearn D AD - Orthodontic Department, School of Dentistry, University of Dundee, Nethergate, Dundee DD1 4HN, Scotland, United Kingdom. LA - eng SI - ClinicalTrials.gov/NCT04001816 GR - CRP.3.MAR14.3/University of The West Indies/ GR - CRP.3.MAR14.3(1)/University of The West Indies/ GR - CRP.3.MAR 14.3(4)/University of The West Indies/ PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Eur J Orthod JT - European journal of orthodontics JID - 7909010 SB - IM MH - Humans MH - *Orthodontic Brackets MH - Female MH - *Orthodontic Appliance Design MH - Patient Satisfaction MH - Adolescent MH - Treatment Outcome MH - Male MH - Tooth Movement Techniques/instrumentation/methods MH - Orthodontic Space Closure MH - Index of Orthodontic Treatment Need MH - Child MH - Time Factors MH - Appointments and Schedules MH - Incisor/pathology MH - Cephalometry MH - Orthodontic Wires MH - Malocclusion/therapy MH - Maxilla/pathology OTO - NOTNLM OT - bimaxillary protrusion OT - conventional brackets OT - randomized clinical trial OT - self-ligating brackets COIS- Conflicts of interest: The authors declare that there is no conflict of interest. EDAT- 2026/03/10 12:56 MHDA- 2026/03/10 12:57 CRDT- 2026/03/10 09:32 PHST- 2026/03/10 12:57 [medline] PHST- 2026/03/10 12:56 [pubmed] PHST- 2026/03/10 09:32 [entrez] AID - 8512766 [pii] AID - 10.1093/ejo/cjag013 [doi] PST - ppublish SO - Eur J Orthod. 2026 Feb 18;48(2):cjag013. doi: 10.1093/ejo/cjag013. PMID- 41805162 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 1464-5033 (Electronic) IS - 0301-4460 (Linking) VI - 53 IP - 1 DP - 2026 Dec TI - Accuracy of the mid-upper arm circumference in screening for overweight and obesity in Argentinian children and adolescents. PG - 2639353 LID - 10.1080/03014460.2026.2639353 [doi] AB - BACKGROUND: In the last two decades, mid-upper arm circumference (MUAC) has gained importance in the assessment of obesity. There is no evidence regarding the accuracy of MUAC for assessing overweight and obesity in Argentina. AIM: To analyse the accuracy of MUAC to identify children and adolescents with overweight/obesity according to body mass index (BMI) status. SUBJECTS AND METHODS: Anthropometric data (weight, height, MUAC) of 7,485 children and adolescents aged 5-17 years were collected in three school surveys between 2005 and 2016. Overweight/obesity was defined using the International Obesity Task Force reference. Receiver Operating Characteristic curve (ROC) analysis was applied to assess the diagnostic performance of MUAC compared to BMI in classifying subjects with overweight/obesity. RESULTS: In both sexes, MUAC and BMI were strongly correlated (r = 0.92). Boys had higher MUAC than girls from age 14 onwards. The overall area under the ROC curve (AUC) in both sexes ranged from 0.93 to 0.99. The MUAC cut-offs increased from 18.5 to 28 cm in boys and from 17.4 to 28 cm in girls and showed high sensitivity and specificity. CONCLUSION: This research provides evidence supporting MUAC as a practical and cost-effective tool for screening and monitoring obesity in paediatric populations. FAU - Orden, Alicia B AU - Orden AB AUID- ORCID: 0000-0003-1768-7753 AD - Instituto de Desarrollo e Investigaciones Pediatricas (IDIP-MS/CIC, PBA), La Plata, Argentina. AD - Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET), Buenos Aires, Argentina. FAU - Fasano, M Victoria AU - Fasano MV AD - Instituto de Desarrollo e Investigaciones Pediatricas (IDIP-MS/CIC, PBA), La Plata, Argentina. AD - Centro de Matematica de La Plata (CMaLP), Facultad de Ciencias Exactas (UNLP), La Plata, Argentina. LA - eng PT - Journal Article DEP - 20260310 PL - England TA - Ann Hum Biol JT - Annals of human biology JID - 0404024 SB - IM MH - Humans MH - Child MH - Argentina/epidemiology MH - Adolescent MH - Male MH - Female MH - *Arm/anatomy & histology MH - Child, Preschool MH - *Overweight/diagnosis/epidemiology MH - Body Mass Index MH - *Anthropometry/methods MH - *Obesity/diagnosis/epidemiology MH - ROC Curve OTO - NOTNLM OT - Mid-upper arm circumference OT - adolescents OT - children OT - obesity EDAT- 2026/03/10 12:55 MHDA- 2026/03/10 12:56 CRDT- 2026/03/10 08:53 PHST- 2026/03/10 12:56 [medline] PHST- 2026/03/10 12:55 [pubmed] PHST- 2026/03/10 08:53 [entrez] AID - 10.1080/03014460.2026.2639353 [doi] PST - ppublish SO - Ann Hum Biol. 2026 Dec;53(1):2639353. doi: 10.1080/03014460.2026.2639353. Epub 2026 Mar 10. PMID- 41804877 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260912 IS - 2047-9980 (Electronic) IS - 2047-9980 (Linking) VI - 15 IP - 6 DP - 2026 Mar 17 TI - Negative and Nonlinear Association Between Particulate Matter and Cardiorespiratory Fitness Among Children and Adolescents: The Mediating Effect of Adiposity. PG - e045789 LID - 10.1161/JAHA.125.045789 [doi] LID - e045789 AB - BACKGROUND: Cardiorespiratory fitness (CRF) has been investigated as a broad, holistic health indicator for children and adolescents. The adverse effects of particulate matter on lung function and cardiovascular health have been widely reported, whereas the association between particulate matter and CRF and its potential pathways remains unclear. The study aims to estimate the association between particulate matter and CRF in children and adolescents and the mediating effect of adiposity on this association. METHODS: A multistage random cluster sampling method was used to obtain a nationwide sample of 99 995 children and adolescents in China. Daily exposure to particulate matter with aerodynamic diameter /=3) were more likely to develop new caries by follow-up (OR = 4.58; 95% CI = 2.07, 10.11). DISCUSSION: The combined sensitivity and specificity score is comparable to findings from other studies examining CRA. Results support the increased weighting of the score for the presence of visible caries and/or evidence of dental treatment for caries at baseline. Results from this study provide evidence for the CRA tool's predictability. CONCLUSION: The Canadian Caries Risk Assessment Tool for preschoolers has high sensitivity to identify children with high caries risk, and modest specificity to identify children with low caries risk. However, future population-based studies with primary care providers are recommended. CI - Copyright (c) 2026 CDHA | ACHD. FAU - Schroth, Robert J AU - Schroth RJ AD - Department of Preventive Dental Science, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. AD - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. FAU - Siray, Adam AU - Siray A AD - Department of Preventive Dental Science, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. FAU - Lee, Victor Hk AU - Lee VH AD - Department of Preventive Dental Science, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. AD - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. FAU - Olatosi, Olubukola O AU - Olatosi OO AD - Department of Preventive Dental Science, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. AD - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. AD - Department of Oral Biology, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. FAU - Mittermuller, Betty-Anne AU - Mittermuller BA AD - Department of Preventive Dental Science, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. AD - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. FAU - Finch, Amanda AU - Finch A AD - Department of Preventive Dental Science, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. FAU - Hu, Ralph AU - Hu R AD - Department of Preventive Dental Science, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. AD - Children's Hospital Research Institute of Manitoba, Winnipeg, MB, Canada. FAU - Dufour, Lisette AU - Dufour L AD - Health Canada, Ottawa, ON, Canada. FAU - Brondani, Mario AU - Brondani M AD - Department of Oral Health Science, Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada. FAU - Bertone, Mary AU - Bertone M AD - School of Dental Hygiene, Dr. Gerald Niznick College of Dentistry, University of Manitoba, Winnipeg, MB, Canada. FAU - Alai-Towfigh, Hamideh AU - Alai-Towfigh H AD - Department of Preventive Dental Science, Dr. Gerald Niznick College of Dentistry, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20260201 PL - Canada TA - Can J Dent Hyg JT - Canadian journal of dental hygiene : CJDH = Journal canadien de l'hygiene dentaire : JCHD JID - 101234082 RN - Q80VPU408O (Fluorides) SB - IM MH - Humans MH - *Dental Caries/epidemiology/prevention & control MH - Risk Assessment/methods MH - Child, Preschool MH - Prospective Studies MH - Female MH - Sensitivity and Specificity MH - Male MH - Pilot Projects MH - Manitoba/epidemiology MH - Infant MH - Follow-Up Studies MH - Social Class MH - Canada MH - Fluorides/therapeutic use MH - Diet MH - Fluoride Treatment PMC - PMC12962308 OTO - NOTNLM OT - caries risk assessment OT - early childhood caries OT - primary care OT - prospective cohort OT - risk factors OT - sensitivity OT - specificity COIS- The authors declare that there are no conflicts of interest. EDAT- 2026/03/09 17:37 MHDA- 2026/03/09 17:38 PMCR- 2026/03/01 CRDT- 2026/03/09 06:19 PHST- 2024/09/10 00:00 [received] PHST- 2025/02/05 00:00 [revised] PHST- 2025/03/30 00:00 [accepted] PHST- 2026/03/09 17:38 [medline] PHST- 2026/03/09 17:37 [pubmed] PHST- 2026/03/09 06:19 [entrez] PHST- 2026/03/01 00:00 [pmc-release] PST - epublish SO - Can J Dent Hyg. 2026 Feb 1;60(1):9-18. eCollection 2026 Feb. PMID- 41799455 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Lifestyle, health behavior, and oral health differences among dentistry, nutrition, and fine arts university students. PG - 1764709 LID - 10.3389/fpubh.2026.1764709 [doi] LID - 1764709 AB - BACKGROUND/OBJECTIVES: University students' lifestyle habits influence their general and oral health in the medium and long term. This study compared physical activity, dietary habits, tobacco and alcohol consumption, and oral hygiene practices among students of Dentistry, Nutrition, and Fine Arts, aiming to identify differences that may guide future preventive interventions. METHODS: A descriptive cross-sectional study was conducted between June and July 2025 at the ADEMA University School (Palma de Mallorca, Spain). The final sample included 165 students (115 Dentistry, 32 Nutrition, and 18 Fine Arts) aged 18-30 years. A validated self-administered questionnaire, adapted from World Health Organization instruments and the ENALIA study, was used to collect sociodemographic variables, physical activity level, screen time, dietary habits, tobacco and alcohol use, and oral hygiene practices. Data were analyzed using descriptive statistics; chi(2) and ANOVA tests were applied according to variable type, with statistical significance set at p < 0.05. The study was approved by the Balearic Islands Research Ethics Committee (IB 5691/24 PI). RESULTS: Nutrition students exhibited the healthiest profiles: 60% reported >/=2-3 h/week of exercise and higher daily fruit and vegetable intake. Dentistry students showed the best self-perceived oral health and the greatest brushing frequency. Fine Arts students exhibited higher sedentary behavior and poorer dietary and oral hygiene habits. Significant differences among degree programs were found in physical activity, diet, and oral health variables (p < 0.05). CONCLUSIONS: Relevant differences in lifestyle and health behaviors were observed according to academic degree. University education appears to influence the adoption of healthy habits; therefore, health promotion programs integrating oral health as an essential component of overall well-being are recommended. CI - Copyright (c) 2026 Coll Campayo, Servera Fuster and Lopez-Safont. FAU - Coll Campayo, Irene AU - Coll Campayo I AD - Faculty of Dentistry, University ADEMA School, Palma, Spain. AD - ADEMA-Health Group, University Institute for Research in Health Sciences (IUNICS), Palma, Spain. FAU - Servera Fuster, Maria AU - Servera Fuster M AD - Faculty of Dentistry, University ADEMA School, Palma, Spain. FAU - Lopez-Safont, Nora AU - Lopez-Safont N AD - Faculty of Dentistry, University ADEMA School, Palma, Spain. AD - ADEMA-Health Group, University Institute for Research in Health Sciences (IUNICS), Palma, Spain. AD - Biology Department, University of the Balearic Islands, Palma, Spain. LA - eng PT - Journal Article DEP - 20260220 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Young Adult MH - *Oral Health/statistics & numerical data MH - Male MH - Adolescent MH - *Health Behavior MH - *Life Style MH - Universities MH - Adult MH - *Students/statistics & numerical data/psychology MH - Spain MH - Exercise MH - Oral Hygiene/statistics & numerical data MH - Surveys and Questionnaires MH - Feeding Behavior PMC - PMC12963299 OTO - NOTNLM OT - dietary habits OT - health behaviors OT - health promotion OT - lifestyle OT - oral health OT - physical activity OT - university students COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/09 17:36 MHDA- 2026/03/09 17:37 PMCR- 2026/02/20 CRDT- 2026/03/09 06:18 PHST- 2025/12/10 00:00 [received] PHST- 2026/01/12 00:00 [revised] PHST- 2026/01/26 00:00 [accepted] PHST- 2026/03/09 17:37 [medline] PHST- 2026/03/09 17:36 [pubmed] PHST- 2026/03/09 06:18 [entrez] PHST- 2026/02/20 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1764709 [doi] PST - epublish SO - Front Public Health. 2026 Feb 20;14:1764709. doi: 10.3389/fpubh.2026.1764709. eCollection 2026. PMID- 41798194 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Short stature-related factors and nomogram-based risk prediction in children aged 7-12: evidence from Chaozhou, China. PG - 1598683 LID - 10.3389/fendo.2026.1598683 [doi] LID - 1598683 AB - OBJECTIVE: Childhood height development is a crucial indicator of public health, with the prevalence of short stature serving as an important metric. This study aimed to investigate the height development status, prevalence of short stature, and associated risk factors among 7-12-year-old children in Chaozhou City, China, providing valuable reference data for local prevention and intervention strategies to address short stature. METHODS: A cross-sectional survey on the height of 7-12-year-old children was conducted in Chaozhou City, Guangdong Province, China. Standardized measurement tools were used to collect height data for epidemiological analysis. To explore risk factors for short stature, a questionnaire survey was administered to a random sample of the surveyed population. Univariate and multivariate logistic regression analyses were conducted to identify factors associated with the risk of short stature and to construct a predictive model. RESULTS: A total of 7,799 children participated in the height survey. Girls had significantly higher mean heights than boys at ages 8, 11, and 12 (all P < 0.001). The overall prevalence of short stature was 3.7%. Although girls had a higher prevalence than boys (4.0% vs. 3.4%), the difference was not statistically significant (P = 0.167). Multivariate logistic regression identified independent risk factors for short stature, including paternal height < 160 cm, maternal height <150 cm, birth weight < 2.5 kg, preterm birth, exercising < 3 times per week, sleep duration < 8 hours per day, and irregular diet. A preference for meat and dairy products was independently associated with a reduced risk of short stature. The nomogram model developed based on these factors demonstrated good predictive performance, with an area under the curve of 0.858 (95%CI 0.815-0.900). CONCLUSIONS: The overall prevalence of short stature in 7-12-year-old children in Chaozhou was slightly higher than the national average. This study analyzed the risk factors for short stature in children, and the risk prediction model developed from these factors demonstrated good predictive accuracy for short stature prevalence. However, external validation in independent cohorts is necessary to confirm the robustness of the model. CI - Copyright (c) 2026 Zhang, Lin, Xu and Cai. FAU - Zhang, Qun AU - Zhang Q AD - Department of Endocrinology, Chaozhou Central Hospital, Chaozhou, China. FAU - Lin, Huarong AU - Lin H AD - Department of Endocrinology, Chaozhou Central Hospital, Chaozhou, China. FAU - Xu, Wencan AU - Xu W AD - The First Affiliated Hospital of Shantou University Medical College, Shantou, China. FAU - Cai, Yifeng AU - Cai Y AD - Department of Critical Care Medicine, Chaozhou Central Hospital, Chaozhou, China. LA - eng PT - Journal Article DEP - 20260220 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - Male MH - Female MH - China/epidemiology MH - Child MH - *Body Height/physiology MH - *Nomograms MH - Risk Factors MH - Cross-Sectional Studies MH - Prevalence MH - *Growth Disorders/epidemiology MH - Surveys and Questionnaires PMC - PMC12962942 OTO - NOTNLM OT - Chaozhou City OT - height development OT - risk factors OT - risk prediction model OT - short stature COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/09 17:36 MHDA- 2026/03/09 17:37 PMCR- 2026/02/20 CRDT- 2026/03/09 06:08 PHST- 2025/03/23 00:00 [received] PHST- 2026/01/10 00:00 [revised] PHST- 2026/01/13 00:00 [accepted] PHST- 2026/03/09 17:37 [medline] PHST- 2026/03/09 17:36 [pubmed] PHST- 2026/03/09 06:08 [entrez] PHST- 2026/02/20 00:00 [pmc-release] AID - 10.3389/fendo.2026.1598683 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Feb 20;17:1598683. doi: 10.3389/fendo.2026.1598683. eCollection 2026. PMID- 41797658 OWN - NLM STAT- MEDLINE DCOM- 20261008 LR - 20261010 IS - 1469-8749 (Electronic) IS - 0012-1622 (Print) IS - 0012-1622 (Linking) VI - 68 IP - 11 DP - 2026 Nov TI - Exoskeleton-assisted physiotherapy in school and outpatient contexts for minimally ambulant children with cerebral palsy. PG - 1580-1592 LID - 10.1111/dmcn.70212 [doi] AB - AIM: To assess the clinical feasibility of lower-limb pediatric exoskeleton-assisted (Trexo Plus) physiotherapy for minimally ambulatory children at an outpatient center and a primary school. Secondary aims were to assess associated functional and goal-based outcomes before and after Trexo-based physiotherapy. METHOD: Ten children with cerebral palsy participated (five males; mean age 5 years 9 months; Gross Motor Function Classification System level IV). Trexo intervention (twice weekly for 6 weeks) was provided in school (gym class/individual physiotherapy) and outpatient (individual physiotherapy) settings by a physiotherapist two-person team. Independent physiotherapy (motor/functional) assessments occurred pre-intervention, 1-week post-intervention, and 5-weeks post-intervention. RESULTS: Fifteen of 16 clinical feasibility indicators were met. Every participant completed the intervention and Trexo use was found to be safe (two adverse skin events in one child). Children reported high enjoyment and comfort during Trexo-facilitated activities, and exercise-linked fatigue. Canadian Occupational Performance Measure and Goal Attainment Scale functional goals were achieved overall, but there was no meaningful increase in Gross Motor Function Measure (88 items; mean change +1.0). Gait assessments showed no increase in 1-minute walk distance but did show enhanced gait maneuverability and reduced physiotherapist assistance when children used their supported-stepping walker. INTERPRETATION: Exoskeleton-based therapy was safe, feasible, and associated with achieving Trexo intervention-focused goals in school and outpatient settings with physiotherapist team support. CI - (c) 2026 The Author(s). Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press. FAU - Bradley, Stefanie S AU - Bradley SS AUID- ORCID: 0009-0009-4283-3573 AD - Holland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, Toronto, ON, Canada. AD - Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada. FAU - Chau, Tom AU - Chau T AUID- ORCID: 0000-0002-7486-0316 AD - Holland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, Toronto, ON, Canada. AD - Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada. FAU - Kawamura, Anne AU - Kawamura A AUID- ORCID: 0000-0002-5088-3011 AD - Holland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, Toronto, ON, Canada. AD - Department of Paediatrics, University of Toronto, Toronto, ON, Canada. FAU - Wright, F Virginia AU - Wright FV AUID- ORCID: 0000-0002-9713-4536 AD - Holland Bloorview Kids Rehabilitation Hospital, Bloorview Research Institute, Toronto, ON, Canada. AD - Department of Physical Therapy, University of Toronto, Toronto, ON, Canada. LA - eng GR - Centre for Leadership Grant, Kimel Graduate Scholarship in Pediatric Disability, and Whipper Watson Graduate Scholarship: Bloorview Research Institute; SPARK Lab Operating Funds/ GR - RGPIN-2019-06033/Natural Sciences and Engineering Research Council of Canada, Grant/Award Number/ GR - PHD00421/Cerebral Palsy Alliance Research Foundation (Australia). Grant/Award Number/ PT - Journal Article DEP - 20260309 PL - England TA - Dev Med Child Neurol JT - Developmental medicine and child neurology JID - 0006761 SB - IM MH - Humans MH - *Cerebral Palsy/rehabilitation MH - Male MH - Female MH - Child MH - Child, Preschool MH - *Exoskeleton Device MH - *Physical Therapy Modalities/instrumentation MH - Outpatients MH - Feasibility Studies MH - Schools MH - Treatment Outcome PMC - PMC13649301 COIS- The authors have stated that they had no interests that might be perceived as posing a conflict or bias. EDAT- 2026/03/09 07:41 MHDA- 2026/10/09 03:58 PMCR- 2026/10/08 CRDT- 2026/03/09 05:43 PHST- 2026/01/10 00:00 [revised] PHST- 2025/02/08 00:00 [received] PHST- 2026/01/21 00:00 [accepted] PHST- 2026/10/09 03:58 [medline] PHST- 2026/03/09 07:41 [pubmed] PHST- 2026/03/09 05:43 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - DMCN70212 [pii] AID - 10.1111/dmcn.70212 [doi] PST - ppublish SO - Dev Med Child Neurol. 2026 Nov;68(11):1580-1592. doi: 10.1111/dmcn.70212. Epub 2026 Mar 9. PMID- 41796965 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20261016 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 123 IP - 5 DP - 2026 May TI - Monitoring growth and body composition in children with 3-dimensional optical imaging: a pilot observational study. PG - 101256 LID - S0002-9165(26)00065-1 [pii] LID - 10.1016/j.ajcnut.2026.101256 [doi] AB - BACKGROUND: Nutritional disturbances among United States children and adolescents have risen sharply in recent decades. Current guidelines emphasize assessing body composition to track changes in fat mass (FM) and fat-free mass (FFM) after interventions. Three-dimensional optical (3DO) imaging has been validated in cross-sectional pediatric samples, although its accuracy in detecting longitudinal change has not been studied. OBJECTIVES: This study evaluated the ability of 3DO imaging to monitor body composition over time in children and adolescents. METHODS: A subsample of 26 ethnically diverse healthy children and adolescents from the Shape Up! Kids study completed whole-body dual-energy X-ray absorptiometry (DXA) and 3DO scans at baseline and again >/=1 y later. 3DO meshes were registered to a standardized template for vertex correspondence, transformed into principal components with an established shape model, and used to estimate whole-body and regional body composition measures using published equations. Body composition changes from 3DO scans were compared with DXA using linear regression and root mean square error (RMSE) to quantify error. Duplicate baseline scans provided least significant change (LSC) estimates to assess whether observed 3DO imaging changes reflected true changes in body composition. RESULTS: At baseline, mean +/- SD age was 10.2 +/- 3.2 y, with a mean +/- SD body mass index z-score of 0.56 +/- 1.29. On average, there were 1.6 y (range: 12-18 mo) between baseline and follow-up. Agreement between 3DO imaging and DXA (R(2)) for changes in total FM, FFM, and appendicular lean mass was 0.82, 0.81, and 0.77, respectively, with RMSEs of 2.29 kg, 2.79 kg, and 0.78 kg, respectively. Of the sample, 75% to 80% of significant changes in FM and FFM based on DXA LSCs were also categorized as significant by 3DO imaging. CONCLUSIONS: 3DO imaging is capable of monitoring body composition changes over time in children and adolescents. The accuracy, safety, and accessibility of this approach support its feasibility for risk screening in this population. This trial was registered at clinicaltrials.gov as NCT03706612. CI - Published by Elsevier Inc. FAU - Bennett, Jonathan P AU - Bennett JP AD - Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, United States. Electronic address: jbennett@cc.hawaii.edu. FAU - Wong, Michael C AU - Wong MC AD - Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, United States; Abbott Nutrition, Columbus, OH, United States. FAU - Tian, Isaac Y AU - Tian IY AD - Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, United States. FAU - Bowen, Aimee AU - Bowen A AD - Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, United States. FAU - Liu, Yong E AU - Liu YE AD - Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, United States. FAU - Kelly, Nisa N AU - Kelly NN AD - Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, United States. FAU - Ramirez, Sophia AU - Ramirez S AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Chow, Dominic AU - Chow D AD - John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, United States. FAU - Pujades, Sergi AU - Pujades S AD - Institute for Research in Digital Science and Technology (INRIA), Universite Grenoble Alpes, CNRS, Grenoble INP, LJK, Grenoble, France. FAU - Garber, Andrea K AU - Garber AK AD - Department of Pediatrics, University of California San Francisco, San Francisco, CA, United States. FAU - Maskarinec, Gertraud AU - Maskarinec G AD - Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, United States. FAU - Heymsfield, Steven B AU - Heymsfield SB AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Shepherd, John A AU - Shepherd JA AD - Department of Epidemiology, University of Hawaii Cancer Center, Honolulu, HI, United States. LA - eng SI - ClinicalTrials.gov/NCT03706612 GR - R01 DK111698/DK/NIDDK NIH HHS/United States GR - R01 HD082166/HD/NICHD NIH HHS/United States GR - U54 MD007601/MD/NIMHD NIH HHS/United States PT - Journal Article PT - Observational Study DEP - 20260307 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - Child MH - *Body Composition MH - Female MH - Pilot Projects MH - Male MH - Adolescent MH - Absorptiometry, Photon MH - *Imaging, Three-Dimensional/methods MH - *Optical Imaging/methods MH - Longitudinal Studies MH - Body Mass Index MH - Cross-Sectional Studies PMC - PMC13660996 MID - NIHMS2210570 OTO - NOTNLM OT - 3-dimensional optical imaging OT - body composition OT - longitudinal study OT - metabolic disease OT - obesity OT - pediatrics COIS- Conflict of interest JAS reports financial support was provided by National Institutes of Health. SBH reports his role on the Medical Advisory Boards of Tanita Corporation, Regeneron, Amgen, and Medifast and financial support was provided by National Institutes of Health. AKG's time is in part supported by the National Institutes of Health (R01HD082166). DC's time is in part supported by the National Institutes of Health (U54MD007601 and OTA-21-015A). All other authors report no conflicts of interest. EDAT- 2026/03/09 07:41 MHDA- 2026/05/04 00:31 PMCR- 2026/10/13 CRDT- 2026/03/09 00:48 PHST- 2025/09/23 00:00 [received] PHST- 2026/01/12 00:00 [revised] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/05/04 00:31 [medline] PHST- 2026/03/09 07:41 [pubmed] PHST- 2026/03/09 00:48 [entrez] PHST- 2026/10/13 00:00 [pmc-release] AID - S0002-9165(26)00065-1 [pii] AID - 10.1016/j.ajcnut.2026.101256 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 May;123(5):101256. doi: 10.1016/j.ajcnut.2026.101256. Epub 2026 Mar 7. PMID- 41796691 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Mar 9 TI - Assessment of construct validity and reliability of the Canadian Ultra-Processed Product Screener. PG - e69 LID - 10.1017/S1368980026102304 [doi] LID - e69 AB - OBJECTIVE: The Canadian Ultra-Processed Product Screener (CUPS) was developed to rapidly assess ultra-processed food (UPF) and drink product intake among Canadian adults. The CUPS is an online self-administered screener that includes twenty-eight questions and assesses the intake of a variety of UPF available in Canada, both in French and English. This study aimed to assess the construct validity and reliability of the CUPS among a sample of adults in Canada. DESIGN: Cross-sectional study (between July and November 2023). SETTINGS: Participants completed the online CUPS screener in three versions (1-d (twice), 7-d and 30-d CUPS) and three 24-h dietary recalls (24HR) (the reference measure) over the course of 26-28 d. PARTICIPANTS: 354 Canadians aged 18-60 years. RESULTS: The CUPS had an acceptable construct validity, with moderate correlation coefficients between the CUPS score and UPF consumption level measured using multiple 24HR (from 0.33 to 0.44). Reproducibility was also acceptable (intraclass correlation = 0.61) and internal consistency ranged from good to excellent (Cronbach's alpha = 0.72 for the 1-d and 0.86 for the 30-d CUPS). CUPS scores were also associated with higher intake of added sugars, saturated fats and Na. CONCLUSIONS: This study provides evidence supporting the construct validity and reliability of the CUPS among Canadian adults. The CUPS is useful for identifying low and high consumers of UPF and could serve as a proxy measure for one key dimension of diet quality, which is the type of food processing. FAU - Hamel, Virginie AU - Hamel V AUID- ORCID: 0000-0001-8467-3138 AD - Department de Nutrition, https://ror.org/0161xgx34Universite de Montreal, Montreal, Canada. FAU - Desmarais, Sara AU - Desmarais S AUID- ORCID: 0009-0006-7233-0078 AD - Department de Nutrition, https://ror.org/0161xgx34Universite de Montreal, Montreal, Canada. FAU - Kirkpatrick, Sharon AU - Kirkpatrick S AUID- ORCID: 0000-0001-9896-5975 AD - School of Public Health and Health Systems, University of Waterloo, Waterloo, Canada. FAU - Y Polsky, Jane AU - Y Polsky J AUID- ORCID: 0009-0009-0926-8234 AD - Department of Health Analysis Division, Statistics Canada, Ottawa, Canada. FAU - Byker Shanks, Carmen AU - Byker Shanks C AD - Gretchen Swanson Center for Nutrition, Omaha, NE, USA. FAU - da Costa Louzada, Maria Laura AU - da Costa Louzada ML AD - Department of Nutricao, Universidade de Sao Paulo Faculdade de Saude Publica, Sao Paulo, Brazil. FAU - Vanderlee, Lana AU - Vanderlee L AUID- ORCID: 0000-0001-5384-1821 AD - Ecole de Nutrition, Universite Laval, Quebec, Canada. FAU - Hamond, David AU - Hamond D AD - School of Public Health and Health Systems, University of Waterloo, Waterloo, Canada. FAU - Gariguet, Didier AU - Gariguet D AD - Department of Health Analysis Division, Statistics Canada, Ottawa, Canada. FAU - Moubarac, Jean-Claude AU - Moubarac JC AD - Department de Nutrition, https://ror.org/0161xgx34Universite de Montreal, Montreal, Canada. LA - eng PT - Journal Article PT - Validation Study DEP - 20260309 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Reproducibility of Results MH - Canada MH - Adult MH - Cross-Sectional Studies MH - Female MH - Middle Aged MH - Food, Processed MH - Adolescent MH - Young Adult MH - Male MH - *Fast Foods/statistics & numerical data MH - *Diet Surveys/methods MH - *Diet/statistics & numerical data MH - Surveys and Questionnaires/standards PMC - PMC13087981 OTO - NOTNLM OT - Construct validity OT - Dietary assessment OT - Reliability OT - Screener OT - Ultra-processed foods COIS- There are no conflicts of interest. EDAT- 2026/03/09 07:41 MHDA- 2026/04/01 07:04 PMCR- 2026/03/09 CRDT- 2026/03/09 00:44 PHST- 2026/04/01 07:04 [medline] PHST- 2026/03/09 07:41 [pubmed] PHST- 2026/03/09 00:44 [entrez] PHST- 2026/03/09 00:00 [pmc-release] AID - S1368980026102304 [pii] AID - 10.1017/S1368980026102304 [doi] PST - epublish SO - Public Health Nutr. 2026 Mar 9;29(1):e69. doi: 10.1017/S1368980026102304. PMID- 41795723 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20261009 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 3 DP - 2026 Mar 8 TI - Expanding the Coffin-Siris syndrome spectrum: genetic, dysmorphic, and endocrine findings in eight cases. LID - 167 [pii] LID - 10.1007/s00431-026-06830-9 [doi] AB - This study aims to expand the spectrum of Coffin-Siris syndrome (CSS), a rare and heterogeneous disorder, by thoroughly discussing its genetic, dysmorphic, and endocrine features through new cases and contributing to the literature. Eight patients who were referred to the genetics clinic with various complaints and subsequently diagnosed with CSS through microarray or clinical exome sequencing analyses were included in the study. The dysmorphic, genetic, and endocrine characteristics of eight genetically confirmed patients were evaluated. The patients, aged between 5 months and 6 years at the time of referral, comprised four females and four males. The most common reasons for referral were developmental delay and dysmorphic features. All patients exhibited varying degrees of dysmorphic facial features. Hypertrichosis, a typical feature of the syndrome, was present in five patients. Another characteristic finding was mild hypoplasia of the terminal fifth phalanges, observed in patients 1, 2, and 6. Consistent with this, mild/subtle hypoplasia and/or slight positional changes of the fifth fingernails were noted in these patients, rather than overt nail anomalies. In our study, eight variants were identified, two of which were novel. In our cohort, pathological short stature was observed in three patients, while hypothyroidism, transient hypercalcemia, cryptorchidism, and recurrent fractures were each identified in one patient. All three patients with short stature had delayed bone age with head circumference and BMI < - 2 SDS. Seven patients were diagnosed with ARID1B-related CSS type 1, while one patient was diagnosed with SMARCA4-related CSS type 4. Among the eight findings across patients, two were deletion-type copy-number variations (CNVs) identified by microarray analysis, and six were sequence variants: two frameshift, two splice-site, one nonsense, and one synonymous. Seven variants were classified as pathogenic and one as likely pathogenic. Family studies confirmed that the variants were de novo and validated their clinical relevance. CONCLUSION: CSS is a clinically and genetically heterogeneous syndrome. Patients may present with highly variable features, and typical signs of the syndrome may not be observed in all cases. This study expands the clinical spectrum of this rare syndrome and contributes to its genetic spectrum with the identification of new variants. WHAT IS KNOWN: * Coffin-Siris syndrome (CSS) is a clinically and genetically heterogeneous neurodevelopmental disorder most commonly caused by variants in SWI/SNF (BAF) complex genes (e.g., ARID1B, SMARCA4) and characterized by dysmorphic features, developmental delay, hypertrichosis, and fifth-digit/nail anomalies. * Endocrine and growth-related manifestations can occur in CSS, but their frequency and phenotypic range vary across cohorts and require individualized clinical follow-up. WHAT IS NEW: * This case series of eight genetically confirmed CSS patients (7 ARID1B, 1 SMARCA4) expands the phenotypic spectrum by detailing dysmorphic findings together with endocrine features including pathological short stature with delayed bone age, hypothyroidism, transient hypercalcemia, cryptorchidism, and recurrent fractures. * We identified eight pathogenic/likely pathogenic variants, including two novel variants, and highlight that fifth digit/nail involvement may be subtle (mild terminal fifth phalanx hypoplasia and minor fifth nail changes) rather than overt. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Kolkiran, Abdulkerim AU - Kolkiran A AUID- ORCID: 0000-0001-9316-9910 AD - Department of Pediatric Genetics, Ankara Etlik City Hospital, Ankara, Turkey. kolkiranaa@gmail.com. FAU - Ataseven Kulali, Melike AU - Ataseven Kulali M AUID- ORCID: 0000-0001-6377-6162 AD - Department of Pediatric Genetics, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Dasar, Tugba AU - Dasar T AUID- ORCID: 0000-0002-1493-4352 AD - Department of Pediatric Genetics, Sincan Training and Research Hospital, Ankara, Turkey. FAU - Kablan, Ahmet AU - Kablan A AUID- ORCID: 0000-0002-8966-2208 AD - Department of Medical Genetics, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Tasdelen, Elifcan AU - Tasdelen E AUID- ORCID: 0000-0003-3917-9792 AD - Department of Medical Genetics, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Atay, Gulsum AU - Atay G AUID- ORCID: 0000-0001-8710-1426 AD - Department of Developmental and Behavioral Pediatrics, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Sarikaya Ozdemir, Behiye AU - Sarikaya Ozdemir B AUID- ORCID: 0000-0002-2821-3038 AD - Department of Pediatric Endocrinology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Savas Erdeve, Senay AU - Savas Erdeve S AUID- ORCID: 0000-0002-4164-5089 AD - Department of Pediatric Endocrinology, Ankara Etlik City Hospital, Ankara, Turkey. AD - Department of Pediatric Endocrinology, University of Health Sciences, Ankara Etlik City Hospital, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260308 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 0 (Transcription Factors) RN - 0 (DNA-Binding Proteins) RN - Coffin-Siris syndrome SB - IM MH - Humans MH - Male MH - *Hand Deformities, Congenital/genetics/diagnosis MH - *Micrognathism/genetics/diagnosis MH - *Neck/abnormalities MH - Child, Preschool MH - Infant MH - Female MH - *Abnormalities, Multiple/genetics/diagnosis MH - Child MH - *Intellectual Disability/genetics/diagnosis MH - *Face/abnormalities MH - Transcription Factors/genetics MH - DNA-Binding Proteins/genetics MH - Phenotype MH - Exome Sequencing OTO - NOTNLM OT - ARID1B OT - SMARCA4 OT - Coarse face OT - Coffin-Siris syndrome (CSS) OT - Developmental delay OT - Endocrine features OT - Facial dysmorphism OT - Hypertrichosis COIS- Declarations. Competing interests: The authors declare no competing interests. AI-use disclosure statement: We confirm that an AI-based tool was used only for English language editing (grammar, spelling, and readability). No AI tool was used to generate scientific content, interpret data, or draw conclusions. The authors reviewed and approved the final text and take full responsibility for the manuscript. EDAT- 2026/03/08 19:22 MHDA- 2026/03/08 19:23 CRDT- 2026/03/08 12:03 PHST- 2026/01/14 00:00 [received] PHST- 2026/02/27 00:00 [accepted] PHST- 2026/02/21 00:00 [revised] PHST- 2026/03/08 19:23 [medline] PHST- 2026/03/08 19:22 [pubmed] PHST- 2026/03/08 12:03 [entrez] AID - 10.1007/s00431-026-06830-9 [pii] AID - 10.1007/s00431-026-06830-9 [doi] PST - epublish SO - Eur J Pediatr. 2026 Mar 8;185(3):167. doi: 10.1007/s00431-026-06830-9. PMID- 41795130 OWN - NLM STAT- MEDLINE DCOM- 20260921 LR - 20260921 IS - 1601-0825 (Electronic) IS - 1354-523X (Linking) VI - 32 IP - 7 DP - 2026 Jul TI - Multimodal Deep Learning-Based Screening of Degenerative Temporomandibular Joint Disease Using 2D Radiography: A Cost-Effective and Low-Radiation Approach. PG - 2007-2015 LID - 10.1111/odi.70268 [doi] AB - OBJECTIVES: This study aimed to develop and preliminarily validate a multimodal deep learning model based on two-dimensional maxillofacial imaging for screening temporomandibular joint (TMJ) degenerative joint disease (DJD). METHODS: A total of 1000 TMJs from 500 orthodontic patients were retrospectively analyzed. TMJ DJD diagnoses based on cone-beam computed tomography served as the reference standard, with substantial interrater agreement. A fine-tuned YOLOv8 model was used to localize condyles on panoramic radiographs. EfficientNetV2 networks extracted features from panoramic radiographs and lateral cephalograms, which were fused with patient age and sex for final classification. RESULTS: The YOLOv8 model achieved an mAP50 of 0.995 for condylar localization. The multimodal model demonstrated strong screening performance, achieving an AUC of 0.898, with notable sensitivity and specificity on the test set. Grad-CAM analyses indicated attention to clinically relevant structures, and panoramic radiographs and lateral cephalograms provided complementary diagnostic information. Integrating both 2D modalities improved performance compared with panoramic radiographs alone. CONCLUSIONS: This multimodal deep learning model enables effective, low-radiation, and cost-efficient screening for TMJ DJD using widely available 2D radiographs. Combining panoramic and lateral cephalometric imaging represents a promising approach for enhancing clinical screening accuracy. Larger multicenter studies are warranted for further validation. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Xiong, Xin AU - Xiong X AUID- ORCID: 0000-0003-2175-0970 AD - State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. FAU - Yang, Ming AU - Yang M AD - State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. FAU - Zheng, Yunhao AU - Zheng Y AUID- ORCID: 0000-0002-4906-2830 AD - State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. FAU - Zhao, Liang AU - Zhao L AD - Dyania Health, New Jersey, USA. FAU - Li, Kang AU - Li K AD - West China Biomedical Big Data Center, Med-X Center for Informatics, Sichuan University, Chengdu, China. FAU - Wang, Jun AU - Wang J AUID- ORCID: 0000-0002-9040-6295 AD - State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China. LA - eng GR - 2025ZNSFSC1586/Natural Science Foundation of Sichuan Province of China/ GR - 82301129/the National Natural Science Foundation of China/ GR - 82471024/the National Natural Science Foundation of China/ PT - Journal Article DEP - 20260307 PL - Denmark TA - Oral Dis JT - Oral diseases JID - 9508565 SB - IM MH - Humans MH - *Temporomandibular Joint Disorders/diagnostic imaging MH - *Deep Learning MH - Female MH - Retrospective Studies MH - Radiography, Panoramic/economics/methods MH - Cone-Beam Computed Tomography MH - Male MH - Cost-Benefit Analysis MH - Adult MH - Sensitivity and Specificity MH - Adolescent MH - Young Adult MH - Cephalometry MH - *Osteoarthritis/diagnostic imaging OTO - NOTNLM OT - artificial intelligence OT - deep learning OT - lateral cephalogram OT - multimodal radiography OT - panoramic radiograph OT - temporomandibular joint degenerative joint disease EDAT- 2026/03/08 01:38 MHDA- 2026/09/21 05:34 CRDT- 2026/03/07 23:42 PHST- 2026/01/13 00:00 [revised] PHST- 2025/11/23 00:00 [received] PHST- 2026/02/16 00:00 [accepted] PHST- 2026/09/21 05:34 [medline] PHST- 2026/03/08 01:38 [pubmed] PHST- 2026/03/07 23:42 [entrez] AID - 10.1111/odi.70268 [doi] PST - ppublish SO - Oral Dis. 2026 Jul;32(7):2007-2015. doi: 10.1111/odi.70268. Epub 2026 Mar 7. PMID- 41794941 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 7 TI - Demirjian's and Cameriere's methods for estimating the 18-year legal age threshold using third molar maturity in a Northern Thai population. LID - 10.1038/s41598-026-43185-5 [doi] LID - 12527 AB - This study evaluated and compared the accuracy of Demirjian's and Cameriere's methods for estimating the 18-year legal age threshold using mandibular third molar maturity in a Northern Thai population. It also aimed to establish population-specific cut-offs. A total of 260 orthopantomograms from healthy Northern Thai individuals aged 14-23 years were retrospectively collected. Bilateral mandibular third molars (teeth 38 and 48) were assessed using Demirjian's stages and Cameriere's third molar maturity index (I3M). Diagnostic indices and receiver operating characteristic (ROC) curves with area under the curve (AUC) values were used to evaluate performance and discriminatory ability at the 18-year threshold. Among Demirjian's stages, only stage H demonstrated consistently high specificity (0.89-0.98) across sexes and tooth sides. Cameriere's method also showed strong performance, with specificity for I3M < 0.08 ranging from 0.83 to 0.98 and increasing markedly when a stricter cut-off of I3M < 0.02 was applied, reaching up to 1.00 in males and 0.98 in females. ROC analysis indicated excellent to outstanding discriminatory accuracy in both sexes and on both sides of the mandibular third molars. These findings showed that Demirjian's stage H and Cameriere's I3M < 0.02 were useful methods for estimating the 18-year legal age threshold. The results highlight the importance of population-specific standards for forensic age assessment in the Northern Thai population. FAU - Chaipattanawan, Nattakan AU - Chaipattanawan N AUID- ORCID: 0000-0001-7219-5407 AD - Division of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 50200, Thailand. FAU - Chamart, Chanakan AU - Chamart C AD - Division of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 50200, Thailand. FAU - Lertromyanant, Chayanin AU - Lertromyanant C AD - Division of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 50200, Thailand. FAU - Guardgasam, Nanthatchaphon AU - Guardgasam N AD - Division of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 50200, Thailand. FAU - Intharasing, Natnapan AU - Intharasing N AD - Division of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 50200, Thailand. FAU - Pithakam, Siriprapa AU - Pithakam S AD - Division of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 50200, Thailand. FAU - Nophachatsathid, Boonchanit AU - Nophachatsathid B AD - Division of Pediatric Dentistry, Department of Orthodontics and Pediatric Dentistry, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 50200, Thailand. FAU - Panyarak, Wannakamon AU - Panyarak W AUID- ORCID: 0000-0003-3557-586X AD - Division of Oral and Maxillofacial Radiology, Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, 50200, Thailand. wannakamon.p@cmu.ac.th. LA - eng PT - Journal Article DEP - 20260307 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Molar, Third/diagnostic imaging/growth & development MH - *Age Determination by Teeth/methods MH - Adolescent MH - Male MH - Female MH - Thailand MH - Radiography, Panoramic MH - Young Adult MH - ROC Curve MH - Retrospective Studies MH - Mandible/diagnostic imaging PMC - PMC13087314 OTO - NOTNLM OT - Chronological age prediction OT - Dental age staging OT - Legal age assessment OT - Orthopantomograms OT - Radiographic tooth development COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: This study was approved by the Human Experimentation Committee of the Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand (registration number: 18/2025). The approval was granted under the ethical standards outlined in the Declaration of Helsinki, the Belmont Report, the CIOMS Guidelines, and the International Conference on Harmonization in Good Clinical Practice (ICH-GCP). Informed consent: All procedures performed in this retrospective study involving human participants, based on anonymized clinical records, were in accordance with the ethical standards of the institutional and/or national research committees and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The ethical boards responsible for this study approved the waiver of informed consent due to its retrospective nature. EDAT- 2026/03/08 01:38 MHDA- 2026/06/27 16:09 PMCR- 2026/03/07 CRDT- 2026/03/07 23:21 PHST- 2026/01/15 00:00 [received] PHST- 2026/03/02 00:00 [accepted] PHST- 2026/06/27 16:09 [medline] PHST- 2026/03/08 01:38 [pubmed] PHST- 2026/03/07 23:21 [entrez] PHST- 2026/03/07 00:00 [pmc-release] AID - 10.1038/s41598-026-43185-5 [pii] AID - 43185 [pii] AID - 10.1038/s41598-026-43185-5 [doi] PST - epublish SO - Sci Rep. 2026 Mar 7;16(1):12527. doi: 10.1038/s41598-026-43185-5. PMID- 41794757 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260627 LR - 20260813 IS - 1472-6955 (Print) IS - 1472-6955 (Electronic) IS - 1472-6955 (Linking) VI - 25 IP - 1 DP - 2026 Mar 7 TI - Construction of nursing-sensitive quality indicators for pregnancy-associated venous thromboembolism using the Delphi method. LID - 10.1186/s12912-026-04517-y [doi] LID - 358 AB - BACKGROUND: There is an increasing trend of Pregnancy-associated Venous Thromboembolism (PA-VTE) over the years in China due to postponement of childbearing age, obesity, and the increasing incidence of pregnancy complications, thereby posing a substantial threat to maternal safety. However, there is a lack of a unified standard indicator system for women with PA-VTE. This study aimed to develop applicable nursing-sensitive quality indicators for women with PA-VTE. METHODS: Potential nursing-sensitive quality indicators were initially constructed based on literature review and research group discussion. A Delphi panel of eighteen experts (obstetric nurses, evidence-based nurses, nurse managers) participated in two rounds consultation. RESULTS: The constructed nursing-sensitive quality indicators for the women with PA-VTE included 3 primary indicators, 9 secondary indicators and 24 tertiary indicators. The response rate of the two rounds of expert survey questionnaires was 100%, the expert authority coefficient values of 0.89, and Kendall coordination coefficient W values ranging from 0.093 to 0.136. CONCLUSIONS: The final set of NSQIs, structured according to the Donabedian model, provides a quantifiable framework to guide clinical nursing practice and quality management for women with PA-VTE. Future work should focus on implementing these indicators in different hospital settings, evaluating their feasibility and reliability in routine data collection, and refining the indicator set based on empirical performance and patient outcomes. CLINICAL TRIAL NUMBER: Not applicable. FAU - Yue, Wei AU - Yue W AD - Department of Obstetrics, the Affiliated Foshan Women and Children Hospital, Guangdong Medical University, No.20, Huayang South Road, Shunde District, Guangdong, Foshan, China. FAU - Gao, Yu-Yi AU - Gao YY AD - Department of Obstetrics, the Affiliated Foshan Women and Children Hospital, Guangdong Medical University, No.20, Huayang South Road, Shunde District, Guangdong, Foshan, China. FAU - Qin, Chen AU - Qin C AD - Department of Obstetrics, the Affiliated Foshan Women and Children Hospital, Guangdong Medical University, No.20, Huayang South Road, Shunde District, Guangdong, Foshan, China. FAU - Chen, Shan-Xia AU - Chen SX AD - Health Management&Biotechnology School, Guangdong Food and Drug Vocational College, Guangzhou, Guangdong, China. FAU - Yang, Min AU - Yang M AD - Foshan Third People's Hospital, Foshan, Guangdong, China. FAU - Lin, Xia-Xia AU - Lin XX AD - Department of Obstetrics, the Affiliated Foshan Women and Children Hospital, Guangdong Medical University, No.20, Huayang South Road, Shunde District, Guangdong, Foshan, China. FAU - Lu, De-Mei AU - Lu DM AD - Department of Obstetrics, the Affiliated Foshan Women and Children Hospital, Guangdong Medical University, No.20, Huayang South Road, Shunde District, Guangdong, Foshan, China. 924102126@qq.com. LA - eng PT - Journal Article DEP - 20260307 PL - England TA - BMC Nurs JT - BMC nursing JID - 101088683 PMC - PMC13081401 OTO - NOTNLM OT - Analytic hierarchy process OT - Delphi method OT - Nursing management OT - Pregnancy-associated venous thromboembolism OT - Quality indicators COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Foshan Women and Children Hospital ethics committee (Application number:FSFY-MEC-2023-043). All methods were performed in accordance with the relevant guidelines and regulations. Experts were assured of anonymity and confidentiality. All experts provided the informed consent. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/08 01:38 MHDA- 2026/03/08 01:39 PMCR- 2026/03/07 CRDT- 2026/03/07 23:15 PHST- 2024/10/05 00:00 [received] PHST- 2026/02/27 00:00 [accepted] PHST- 2026/03/08 01:39 [medline] PHST- 2026/03/08 01:38 [pubmed] PHST- 2026/03/07 23:15 [entrez] PHST- 2026/03/07 00:00 [pmc-release] AID - 10.1186/s12912-026-04517-y [pii] AID - 4517 [pii] AID - 10.1186/s12912-026-04517-y [doi] PST - epublish SO - BMC Nurs. 2026 Mar 7;25(1):358. doi: 10.1186/s12912-026-04517-y. PMID- 41794495 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 1873-7145 (Electronic) IS - 0963-9969 (Linking) VI - 230 DP - 2026 Apr 30 TI - Child consumer-centered co-creation for the development of healthy dairy products: Comparative insights from diabetic and non-diabetic children. PG - 118626 LID - S0963-9969(26)00302-9 [pii] LID - 10.1016/j.foodres.2026.118626 [doi] AB - Co-creation has gained relevance as a participatory strategy in food innovation; however, important gaps remain in child-centered applications. First, there is limited evidence on how co-creation processes perform when involving children from different health and dietary contexts, such as those with and without type 1 Diabetes mellitus (DM1). Second, studies integrating visual projective techniques such as Free Drawing into the co-creation process to systematically capture children's implicit perceptions and habitual food consumption are lacking. Third, it remains unclear whether children's participation in co-creation biases sensory acceptance when compared with evaluations conducted by non-participating peers. This study addresses these gaps by proposing and testing a child-centered co-creation framework that explicitly integrates the Free Drawing technique into the exploratory phase of product development. The framework was applied to the development of healthy dairy products enriched with fruits, vegetables, grains, and nuts, involving children with and without DM1. Forty-two Brazilian children (21 with DM1 and 21 without) participated in four co-creation phases (exploration, prototyping, refinement, and validation), while an additional 42 children (21 with DM1 and 21 without) participated exclusively in the validation stage. The Free Drawing technique revealed distinct cognitive representations between groups. Children with DM1 primarily illustrated simpler, sugar-free, or plain dairy products, whereas non-diabetic children depicted a broader range of flavored and processed options, emphasizing sweetness and indulgence. During the co-creation process, ingredient selection for the prototypes reflected four main drivers across groups: familiarity, sensory and hedonic properties, perceived healthiness, and novelty. Children with DM1 adopted a more reflective decision-making approach, incorporating a greater diversity of fruits, assigning imaginative names to their products, and prioritizing familiarity, healthiness, and sensory balance. In contrast, non-diabetic children focused more strongly on sweetness, novelty, and hedonic appeal. The refined prototypes (n = 6 per group) achieved high sensory acceptance, with no significant differences between evaluations conducted by co-creators and non-participant children, indicating that participation in co-creation did not bias sensory outcomes. Overall, this study provides the first comparative evidence that child-centered co-creation is effective across different health contexts and demonstrates that integrating Free Drawing into the co-creation process is a novel and robust methodological strategy for eliciting meaningful insights. Finally, co-creation helps to develop nutritious, low- or no-sugar dairy products aligned with children's sensory expectations. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Ribeiro, Ana Cristina Pinesso AU - Ribeiro ACP AD - State University of Londrina (UEL), Londrina, Brazil. FAU - Esmerino, Erick Almeida AU - Esmerino EA AD - Fluminense Federal University, Rio de Janeiro, Brazil. FAU - Cruz, Adriano Gomes AU - Cruz AG AD - Federal Institute of Education, Science, and Technology of Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Pimentel, Tatiana Colombo AU - Pimentel TC AD - State University of Londrina (UEL), Londrina, Brazil; Federal Institute of Parana, Campus Paranavai, Paranavai, Parana, Brazil. Electronic address: tatiana.pimentel@ifpr.edu.br. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260207 PL - Canada TA - Food Res Int JT - Food research international (Ottawa, Ont.) JID - 9210143 SB - IM MH - Humans MH - Child MH - *Dairy Products MH - Male MH - *Diabetes Mellitus, Type 1/psychology/diet therapy MH - Female MH - Food Preferences MH - Brazil MH - *Consumer Behavior MH - *Diet, Healthy OTO - NOTNLM OT - Children OT - Co-creation OT - Dairy products OT - Food education OT - Food product development COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/08 01:38 MHDA- 2026/03/08 01:39 CRDT- 2026/03/07 20:58 PHST- 2025/10/20 00:00 [received] PHST- 2026/01/22 00:00 [revised] PHST- 2026/02/05 00:00 [accepted] PHST- 2026/03/08 01:39 [medline] PHST- 2026/03/08 01:38 [pubmed] PHST- 2026/03/07 20:58 [entrez] AID - S0963-9969(26)00302-9 [pii] AID - 10.1016/j.foodres.2026.118626 [doi] PST - ppublish SO - Food Res Int. 2026 Apr 30;230:118626. doi: 10.1016/j.foodres.2026.118626. Epub 2026 Feb 7. PMID- 41793330 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 2229-7693 (Electronic) IS - 0019-557X (Linking) VI - 70 IP - 1 DP - 2026 Jan 1 TI - Assessing Parental Understanding and Perspectives on Vitamin A Supplementation for Children: A Quantitative Study using the Health Belief Model. PG - 31-35 LID - 10.4103/ijph.ijph_414_25 [doi] AB - BACKGROUND: Vitamin A deficiency contributes to preventable blindness and child morbidity in developing countries. While Vitamin A supplementation (VAS) is effective, parental perceptions influence adherence. OBJECTIVES: The objective of this study was to identify the predictors of adherence to VAS among parents of children aged 9-59 months using the Health Belief Model (HBM). MATERIALS AND METHODS: A cross-sectional study was conducted among 256 parents attending an immunization center. Data were collected through a validated questionnaire on knowledge and HBM constructs. Logistic regression identified predictors of VAS adherence. RESULTS: 28.1% perceived child as susceptible, and 52.0% recognized benefits of supplementation. Perceived susceptibility (adjusted odds ratio [AOR] = 33.48, 95% confidence interval [CI]: 4.62-242.71), perceived benefits (AOR = 8.82, 95% CI: 1.78-43.79), fewer perceived barriers (AOR = 96.05, 95% CI: 21.84-422.30), and higher self-efficacy (AOR = 8.47, 95% CI: 2.32-30.89) significantly predicted adherence. Perceived severity was not significant. CONCLUSION: Strengthening awareness, reducing barriers, and enhancing parental confidence can improve VAS uptake. CI - Copyright (c) 2026 Indian Journal of Public Health. FAU - Singh, Tulika AU - Singh T AD - Associate Professor, Department of Community Medicine, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India. FAU - Kumar, Sanjay AU - Kumar S AD - Professor, Department of Community Medicine, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India. FAU - Sinha, Setu AU - Sinha S AD - Additional Professor, Department of Community Medicine, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India. FAU - Yasmeen, Tajwar AU - Yasmeen T AD - Assistant Professor, Department of Community Medicine, Indira Gandhi Institute of Medical Sciences, Patna, Bihar, India. LA - eng PT - Journal Article DEP - 20260307 PL - India TA - Indian J Public Health JT - Indian journal of public health JID - 0400673 RN - 11103-57-4 (Vitamin A) SB - IM MH - Humans MH - Cross-Sectional Studies MH - *Parents/psychology MH - Female MH - *Vitamin A/administration & dosage/therapeutic use MH - Male MH - Child, Preschool MH - *Health Knowledge, Attitudes, Practice MH - *Vitamin A Deficiency/prevention & control/drug therapy MH - *Health Belief Model MH - Infant MH - *Dietary Supplements MH - Surveys and Questionnaires MH - Adult OTO - NOTNLM OT - Child health OT - Health Belief Model OT - Vitamin A OT - health attitudes OT - parental role EDAT- 2026/03/07 16:13 MHDA- 2026/03/08 01:37 CRDT- 2026/03/07 09:03 PHST- 2025/04/17 00:00 [received] PHST- 2025/09/10 00:00 [accepted] PHST- 2026/03/08 01:37 [medline] PHST- 2026/03/07 16:13 [pubmed] PHST- 2026/03/07 09:03 [entrez] AID - 01586002-202601000-00007 [pii] AID - 10.4103/ijph.ijph_414_25 [doi] PST - ppublish SO - Indian J Public Health. 2026 Jan 1;70(1):31-35. doi: 10.4103/ijph.ijph_414_25. Epub 2026 Mar 7. PMID- 41793324 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1930-739X (Electronic) IS - 1930-7381 (Print) IS - 1930-7381 (Linking) VI - 34 IP - 5 DP - 2026 May TI - Physical Fitness Cut-Points for Early Detection of Obesity Risk in Preschool Children. PG - 1081-1091 LID - 10.1002/oby.70166 [doi] AB - OBJECTIVE: This study aimed to establish cut-points for cardiorespiratory fitness, muscular strength, and speed-agility and to evaluate their ability to detect general and central obesity risk in preschool children aged 3-5 years. METHODS: Briefly, 3179 Spanish preschoolers (52.8% boys) were evaluated. Physical fitness was assessed with the PREFIT battery. Anthropometry included BMI and waist circumference. Obesity risk was defined using age- and sex-specific percentiles according to criteria established by the World Health Organization and the International Diabetes Foundation. Receiver operating characteristic curve analyses were used to identify fitness cut-points. RESULTS: Age- and sex-specific cut-points were established. For cardiorespiratory fitness, cut-points ranged from 9.5 to 23.5 laps in boys and 6.5 to 21.5 in girls across the 3- to 5-year age range. Muscular strength cut-points ranged from z-scores of -1.5 to 2.2 in boys and -1.6 to 1.9 in girls. Speed-agility cut-points ranged from 18.8 to 14.9 s in boys and 19.9 to 15.3 s in girls. Predictive accuracy was moderate-to-high (AUC range: 0.61-0.74 for cardiorespiratory fitness, 0.59-0.80 for strength, 0.49-0.71 for speed-agility). CONCLUSIONS: This study provides fitness cut-points for detecting general and central obesity risk in preschoolers. Early integration of physical fitness assessments into health monitoring may facilitate early identification of obesity risk. CI - (c) 2026 The Author(s). Obesity published by Wiley Periodicals LLC on behalf of The Obesity Society. FAU - Herrada-Robles, Maria AU - Herrada-Robles M AUID- ORCID: 0009-0005-1284-3296 AD - Department of Physical Education and Sports, Faculty of Sports Science, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. FAU - Labayen, Idoia AU - Labayen I AD - Department of Health Sciences, Public University of Navarra, Institute for Sustainability & Food Chain Innovation, Pamplona, Spain. AD - CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain. FAU - Castro-Pinero, Jose AU - Castro-Pinero J AD - GALENO Research Group, Department of Physical Education, Faculty of Education Sciences, University of Cadiz, Puerto Real, Spain. Instituto de Investigacion e Innovacion Biomedica de Cadiz (INiBICA), Cadiz, Spain. FAU - Martinez-Vizcaino, Vicente AU - Martinez-Vizcaino V AUID- ORCID: 0000-0001-6121-7893 AD - Edificio Melchor Cano, Centro de Estudios Socio-Sanitarios, Universidad de Castilla-La Mancha, Cuenca, Spain. AD - Facultad de Ciencias de la Salud, Universidad Autonoma de Chile, Talca, Chile. FAU - Rojo-Tirado, Miguel A AU - Rojo-Tirado MA AUID- ORCID: 0000-0003-3217-7786 AD - LFE Research Group, Department of Health and Human Performance, Facultad de Ciencias de la Actividad Fisica y del Deporte, Universidad Politecnica de Madrid, Madrid, Spain. FAU - Moliner-Urdiales, Diego AU - Moliner-Urdiales D AUID- ORCID: 0000-0001-9868-3396 AD - LIFE Research Group, Universitat Jaume I, Castellon, Spain. FAU - Sanchis-Moysi, Joaquin AU - Sanchis-Moysi J AUID- ORCID: 0000-0001-6602-7087 AD - Department of Physical Education and Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria, Las Palmas, Spain. FAU - Vidal-Conti, Josep AU - Vidal-Conti J AD - Physical Activity and Sport Sciences Research Group (GICAFE), Faculty of Education, University of the Balearic Islands, Institute for Educational Research and Innovation (IRIE), Palma, Spain. FAU - Vicente-Rodriguez, German AU - Vicente-Rodriguez G AUID- ORCID: 0000-0002-4303-4097 AD - CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain. AD - EXER-GENUD (Growth, Exercise, NUtrition and Development) Research Group (S72_23R), FIMS Collaborating Center of Sports Medicine, Instituto Agroalimentario de Aragon -IA2- (CITA-Universidad de Zaragoza), Exercise and Health Spanish Research Network (EXERNET), Faculty of Health and Sport Science, Huesca, Spain. AD - Department of Physiatry and Nursing, University of Zaragoza, Zaragoza, Spain. FAU - Tomkinson, Grant R AU - Tomkinson GR AD - Alliance for Research in Exercise, Nutrition and Activity (ARENA), School of Allied Health and Human Performance, Adelaide University, Adelaide, Australia. FAU - Cadenas-Sanchez, Cristina AU - Cadenas-Sanchez C AUID- ORCID: 0000-0002-4513-9108 AD - Department of Physical Education and Sports, Faculty of Sports Science, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. AD - CIBER de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Granada, Spain. LA - eng GR - FPU22/01366/Ministerio de Universidades/ GR - RYC-2011-09011/Ramon y Cajal/ GR - 101028929/HORIZON EUROPE Marie Sklodowska-Curie Actions/ GR - NNF23SA0083955/European Association for the Study of Obesity - Novo Nordisk Foundation/ GR - CB22/03/00058/Centro de Investigacion Biomedica en Red-Fisiopatologia de la Obesidad y Nutricion/ GR - JIUZ-2014-BIO-08/Universidad de Zaragoza/ GR - Instituto de Salud Carlos III/ GR - European Regional Development Fund/ PT - Journal Article DEP - 20260307 PL - United States TA - Obesity (Silver Spring) JT - Obesity (Silver Spring, Md.) JID - 101264860 SB - IM MH - Humans MH - Female MH - Male MH - Child, Preschool MH - Muscle Strength MH - *Physical Fitness MH - Body Mass Index MH - Spain/epidemiology MH - ROC Curve MH - Waist Circumference MH - *Cardiorespiratory Fitness MH - Early Diagnosis MH - *Obesity/diagnosis MH - Risk Factors PMC - PMC13116109 COIS- The authors declare no conflicts of interest. EDAT- 2026/03/07 16:11 MHDA- 2026/04/27 12:34 PMCR- 2026/04/27 CRDT- 2026/03/07 08:53 PHST- 2025/12/30 00:00 [revised] PHST- 2025/09/05 00:00 [received] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/04/27 12:34 [medline] PHST- 2026/03/07 16:11 [pubmed] PHST- 2026/03/07 08:53 [entrez] PHST- 2026/04/27 00:00 [pmc-release] AID - OBY70166 [pii] AID - 10.1002/oby.70166 [doi] PST - ppublish SO - Obesity (Silver Spring). 2026 May;34(5):1081-1091. doi: 10.1002/oby.70166. Epub 2026 Mar 7. PMID- 41793297 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261020 IS - 1461-7277 (Electronic) IS - 1359-1053 (Linking) VI - 31 IP - 13 DP - 2026 Nov TI - Psychometric properties and predictive validity of Brazilian reward-based eating drive scale. PG - 5296-5310 LID - 10.1177/13591053261420602 [doi] AB - This study aimed to adapt and validate the Reward-Based Eating Drive Scale (RED-13) for Brazilian Portuguese and assess its psychometric properties and predictive validity. The adaptation process followed established cross-cultural guidelines, including translation, synthesis, back-translation, expert committee review, and pilot testing. Content validity was evaluated using the Content Validity Index. A total of 452 adults aged 18-59 years, recruited online, participated in the psychometric assessment. Confirmatory factor analysis supported the scale's three-dimensional structure (RMSEA < 0.0001, SRMR = 0.041, TLI = 1.000, CFI = 1.000). Internal consistency was high (alpha = 0.921, omega = 0.922). RED-13 BR scores showed moderate correlations with food cravings and weak correlations with body mass index (rho = 0.266, p < 0.001). Receiver operating characteristic analysis indicated predictive ability for pre-obesity and obesity. These findings suggest that the RED-13 BR is a valid and reliable instrument for assessing reward-based eating behavior in Brazilian adults. FAU - da Silva, Taina Lopes AU - da Silva TL AUID- ORCID: 0000-0002-6238-2273 AD - Pontifical Catholic University of Rio Grande Do Sul, PUCRS, Porto Alegre, Brazil. FAU - Vainik, Uku AU - Vainik U AD - University of Tartu, Estonia. AD - McGill University, Montreal, ON, Canada. FAU - Mason, Ashley AU - Mason A AD - Center for Health and Community, San Francisco, CA, USA. AD - UCSF Osher Center for Integrative Health, San Francisco, CA, USA. FAU - Urbanetto, Janete de Souza AU - Urbanetto JS AD - Pontifical Catholic University of Rio Grande Do Sul, PUCRS, Porto Alegre, Brazil. FAU - Feoli, Ana Maria Pandolfo AU - Feoli AMP AD - Pontifical Catholic University of Rio Grande Do Sul, PUCRS, Porto Alegre, Brazil. LA - eng PT - Journal Article PT - Validation Study DEP - 20260307 PL - England TA - J Health Psychol JT - Journal of health psychology JID - 9703616 SB - IM MH - Humans MH - Adult MH - Brazil MH - *Psychometrics/instrumentation MH - Female MH - *Reward MH - Middle Aged MH - *Feeding Behavior/psychology MH - Adolescent MH - Young Adult MH - Reproducibility of Results MH - Male MH - Surveys and Questionnaires/standards MH - Obesity/psychology OTO - NOTNLM OT - eating behavior OT - obesity OT - reward-driven eating OT - reward-related eating OT - validation study COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/03/07 16:13 MHDA- 2026/10/20 17:34 CRDT- 2026/03/07 07:43 PHST- 2026/10/20 17:34 [medline] PHST- 2026/03/07 16:13 [pubmed] PHST- 2026/03/07 07:43 [entrez] AID - 10.1177/13591053261420602 [doi] PST - ppublish SO - J Health Psychol. 2026 Nov;31(13):5296-5310. doi: 10.1177/13591053261420602. Epub 2026 Mar 7. PMID- 41792941 OWN - NLM STAT- MEDLINE DCOM- 20260618 LR - 20260818 IS - 1552-5732 (Electronic) IS - 0890-3344 (Linking) VI - 42 IP - 2 DP - 2026 May TI - Routine Postpartum Colostrum Expression and Breastfeeding Outcomes in Women With Diabetes: A Feasibility Trial. PG - 282-292 LID - 10.1177/08903344261419353 [doi] AB - BACKGROUND: Women with diabetes have an increased risk of delayed Lactogenesis II, and their infants are at higher risk of hypoglycemia and formula supplementation. RESEARCH AIM: To assess the feasibility and acceptability of routine postpartum colostrum expression for women with diabetes, and its influence on exclusive breastfeeding. METHOD: A non-randomized feasibility clinical study was conducted from birth to 30 days postpartum involving women with DM, including those with GDM, from a maternity in Sao Paulo, Brazil in 2021-2022.We aimed to identify challenges related to participant acceptance, adherence to the intervention, retention, and the rates of exclusive breastfeeding, in preparation for a full randomized controlled trial (N = 30). The intervention consisted of providing participants with education on the postpartum colostrum expression as a routine practice and offering the expressed milk to their infant after breastfeeds sessions. RESULTS: We analyzed data from all 30 participants, with 13 in the intervention group and 17 in the control group. More women in the intervention group (12/13, 92%) exclusively breastfed at hospital stay compared with those in the control group (8/17, 47%; p = 0.017). Women in the intervention group reported increased confidence in breastfeeding. Despite barriers like challenges with expression techniques, concerns about milk volume, and labor fatigue, participants found the intervention acceptable. CONCLUSIONS: Postpartum colostrum expression was feasible and acceptable, and may influence exclusive breastfeeding rates among women with diabetes, supporting further research in a larger trial. FAU - Perpetuo, Cinthia Daniela AU - Perpetuo CD AUID- ORCID: 0000-0002-1769-8172 AD - Universidade Federal de Sao Paulo, Brazil. FAU - Bueno, Emily Boaventura AU - Bueno EB AUID- ORCID: 0009-0004-6306-0454 AD - Universidade Federal de Sao Paulo, Brazil. FAU - Amir, Lisa H AU - Amir LH AUID- ORCID: 0000-0002-2510-1399 AD - La Trobe University, Melbourne, VIC, Australia. AD - Breastfeeding Service, Royal Women's Hospital, Melbourne, Australia. FAU - Mattar, Rosiane AU - Mattar R AUID- ORCID: 0000-0003-1405-5371 AD - Universidade Federal de Sao Paulo, Brazil. FAU - Draque, Cecilia AU - Draque C AUID- ORCID: 0000-0002-1583-2753 AD - Universidade Federal de Sao Paulo, Brazil. FAU - Coca, Kelly P AU - Coca KP AUID- ORCID: 0000-0002-3604-852X AD - Universidade Federal de Sao Paulo, Brazil. AD - Ana Abrao Breastfeeding Center, Sao Paulo, Brazil. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260306 PL - United States TA - J Hum Lact JT - Journal of human lactation : official journal of International Lactation Consultant Association JID - 8709498 SB - IM MH - Humans MH - Female MH - *Breast Feeding/statistics & numerical data/methods/psychology MH - Feasibility Studies MH - Adult MH - *Colostrum MH - Brazil MH - *Postpartum Period MH - Pregnancy MH - *Diabetes, Gestational MH - Infant, Newborn OAB - Introducao:Mulheres com diabetes apresentam maior risco de atraso na lactogenese II, e seus recem-nascidos tem maior probabilidade de desenvolver hipoglicemia e necessitar suplementacao com formula infantil.Objetivo:Avaliar a viabilidade e aceitabilidade da extracao rotineira de leite materno no pos-parto por mulheres com diabetes, e seu impacto na amamentacao exclusiva.Metodo:Estudo clinico de viabilidade, nao randomico, com objetivo de avaliar a viabilidade e a aceitabilidade da recomendacao rotineira de extracao de leite materno no pos-parto para mulheres. Foram identificados os desafios relacionados a aceitacao das participantes, a adesao a intervencao, a retencao no estudo e as taxas de amamentacao exclusiva, como parte da preparacao para um futuro ensaio clinico randomizado completo (N=30). Participaram do estudo mulheres com diagnostico de diabetes, incluindo diabetes gestacional, em uma maternidade localizada em Sao Paulo, Brasil, entre 2021 e 2022. A intervencao consistiu em orientacao acerca da pratica rotineira de extracao de leite materno no pos-parto e a oferta do leite ao recem-nascido apos as mamadas.Resultados:Analisou-se um total de 30 participantes, sendo 13 no grupo de intervencao e 17 no grupo controle. A maioria das mulheres no grupo de intervencao (12/13, 92%) amamentou exclusivamente durante a internacao hospitalar, em comparacao com o grupo controle (8/17, 47%) (p=0.017). As mulheres do grupo de intervencao relataram maior confianca na amamentacao. Apesar de barreiras como dificuldades com as tecnicas de extracao de leite materno, preocupacoes com o volume de leite e o cansaco apos o parto, as participantes consideraram a intervencao aceitavel.Conclusao:A extracao de leite materno no pos-parto mostrou-se viavel, aceitavel e pode impactar as taxas de amamentacao exclusiva entre mulheres com diabetes, reforcando a necessidade de estudos adicionais em um ensaio clinico de maior escala. OABL- eng OTO - NOTNLM OT - Diabetes Mellitus OT - Ensaios Clinicos Controlados OT - Extracao de Leite Aleitamento Materno OT - Lactacao OT - Periodo Pos-parto OT - Transtorno da Lactacao OT - breastfeeding OT - colostrum OT - controlled trials OT - delayed lactogenesis OT - diabetes mellitus OT - lactation OT - postpartum COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. KC affirms that her views expressed are your own and not IBLCE's, and that she does not have access to any IBCLC examination materials or other non-public information related to IBLCE credentials. EDAT- 2026/03/07 06:39 MHDA- 2026/06/18 12:33 CRDT- 2026/03/07 00:43 PHST- 2026/06/18 12:33 [medline] PHST- 2026/03/07 06:39 [pubmed] PHST- 2026/03/07 00:43 [entrez] AID - 10.1177/08903344261419353 [doi] PST - ppublish SO - J Hum Lact. 2026 May;42(2):282-292. doi: 10.1177/08903344261419353. Epub 2026 Mar 6. PMID- 41792911 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 1552-681X (Electronic) IS - 0272-989X (Print) IS - 0272-989X (Linking) VI - 46 IP - 5 DP - 2026 Jul TI - Adapting Sexual Behavior Survey Data to Parameterize an Agent-Based Model of Human Papillomavirus (HPV) Transmission. PG - 591-600 LID - 10.1177/0272989X261425681 [doi] AB - PurposeSexual transmission of human papillomavirus (HPV) infection is important for capturing the indirect effects of interventions in mathematical models, but limited data create challenges for reflecting sexual behavior patterns over the lifespan of individuals and across heterogenous populations. We used nationally representative data from the United States to parameterize, calibrate, and validate a heterosexual transmission model of HPV.MethodsBased on sexual behavior data from the National Survey of Family Growth (2011-2019), we categorized respondents into 4 sexual activity categories, using their percentile of cumulative lifetime partners compared with others within their same sex and age group. We modeled probabilistic partnership acquisition and dissolution by age, sex, and sexual activity category. Partnership data were incorporated into an existing agent-based model of HPV transmission in the United States. We calibrated 1) per-partnership HPV transmission and 2) reduced risk of type-specific reinfection from natural immunity to fit age- and type-specific HPV prevalence using the National Health and Nutrition Examination Survey (NHANES 2002-2008). We validated the final model by comparing model-based projections of HPV prevalence against empirical data in the US population before and after widespread HPV vaccination.ResultsAfter calibrating to fit overall HPV prevalence, model validation exercises indicated that the distribution of prevaccine HPV prevalence across sexual activity categories closely matched NHANES estimates. Simulating vaccination rates over 10 y, the model replicated postvaccine NHANES data for prevalence of HPV16.ConclusionCapturing HPV transmission dynamics requires an understanding of sexual behavior across populations and over time. Defining sexual activity categories based on cumulative lifetime partners can capture patterns of HPV risk over a lifespan to reflect the dynamics of HPV transmission and vaccination.HighlightsUsing data from a large national survey, we developed sexual behavior inputs for an agent-based model of HPV transmission.We define 4 heterogenous risk groups using cumulative lifetime sexual behavior for males and females and find we can recreate validation data on both lifetime sexual patterns and age-specific HPV prevalence.Our calibrated model also reproduces early patterns of HPV reduction following HPV vaccine introduction.Modelers seeking to understand the long-term effects of the HPV vaccine should carefully consider the heterogeneity of sexual behavior across groups as well as changes in behavior over the lifespan. FAU - Spencer, Jennifer C AU - Spencer JC AUID- ORCID: 0000-0001-9508-1525 AD - Department of Population Health, Dell Medical School, UT Austin, Austin, TX, USA. AD - Department of Internal Medicine, Dell Medical School, UT Austin, Austin, TX, USA. FAU - Burger, Emily A AU - Burger EA AUID- ORCID: 0000-0002-6657-5849 AD - Department of Health Management and Health Economics, University of Oslo, Oslo, Blindern, Norway. AD - Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA, USA. FAU - Portnoy, Allison AU - Portnoy A AUID- ORCID: 0000-0002-8467-1324 AD - Department of Global Health, Boston University School of Public Health, Boston, MA, USA. FAU - Campos, Nicole G AU - Campos NG AUID- ORCID: 0000-0002-0840-4339 AD - Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA, USA. FAU - Regan, Mary Caroline AU - Regan MC AD - Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA, USA. FAU - Sy, Stephen AU - Sy S AD - Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA, USA. FAU - Kim, Jane J AU - Kim JJ AUID- ORCID: 0000-0002-9892-9170 AD - Center for Health Decision Science, Harvard T.H. Chan School of Public Health, Boston, MA, USA. LA - eng GR - K01 MD017633/MD/NIMHD NIH HHS/United States GR - U01 CA253912/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20260306 PL - United States TA - Med Decis Making JT - Medical decision making : an international journal of the Society for Medical Decision Making JID - 8109073 RN - 0 (Papillomavirus Vaccines) SB - IM MH - Humans MH - *Papillomavirus Infections/transmission/epidemiology/prevention & control MH - Female MH - *Sexual Behavior/statistics & numerical data MH - Male MH - United States/epidemiology MH - Adult MH - *Human Papillomavirus Viruses MH - Middle Aged MH - Adolescent MH - Papillomavirus Vaccines MH - Surveys and Questionnaires MH - Prevalence MH - Nutrition Surveys MH - Young Adult PMC - PMC12970602 MID - NIHMS2145887 OTO - NOTNLM OT - calibration OT - human papillomavirus OT - sexually transmitted infection OT - simulation model OT - vaccination COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by grants from the National Institute of Minority Health and Health Disparities (1K01MD017633-03; PI: Spencer), National Institutes of Health/National Cancer Institute (U01CA253912), and PATH and Bill and Melinda Gates Foundation on behalf of the Single-Dose HPV Vaccine Evaluation Consortium. The funding agreement ensured the author's independence in designing the study, interpreting the data, writing, and publishing the report. EDAT- 2026/03/07 06:38 MHDA- 2026/06/12 00:38 PMCR- 2026/06/07 CRDT- 2026/03/07 00:23 PHST- 2026/06/12 00:38 [medline] PHST- 2026/03/07 06:38 [pubmed] PHST- 2026/03/07 00:23 [entrez] PHST- 2026/06/07 00:00 [pmc-release] AID - 10.1177_0272989X261425681 [pii] AID - 10.1177/0272989X261425681 [doi] PST - ppublish SO - Med Decis Making. 2026 Jul;46(5):591-600. doi: 10.1177/0272989X261425681. Epub 2026 Mar 6. PMID- 41792847 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260627 LR - 20260813 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 12 IP - 1 DP - 2026 Mar 7 TI - Assessment of association between problematic internet use and overweight and obesity among in school adolescents in Addis Ababa, Ethiopia. LID - 10.1186/s40795-026-01295-3 [doi] LID - 69 AB - BACKGROUND: Overweight and obesity among adolescents is one of the most serious public health concerns worldwide in the 21st century. Problematic internet use (PIU) is associated with physical inactivity, sedentary behavior, disrupted sleep, and poor dietary habits, which can contribute to overweight/obesity and adversely affect mental wellbeing among adolescents. Several epidemiological studies, have explored the association between problematic internet use and overweight/obesity and reported inconsistent findings. The majority of the studies in this regard were from developed nations and there are limited studies from developing countries including Ethiopia. OBJECTIVES: The study is aimed to assess the association between problematic internet use and overweight and obesity among secondary school adolescents in Addis Ababa, Ethiopia. METHODS: A school-based cross-sectional study was conducted among adolescents aged 13-19 in public and private secondary schools in Addis Ababa from March to June 2025. A total of 501 adolescents were selected using a three-stage random sampling technique. Problematic internet use was assessed using the validated Amharic version of the Internet Addiction Test (IAT-20). Body Mass Index (BMI) for age Z-score was compared to WHO 2007 growth reference standards using WHO Anthro plus version 3.2.2 software. Data were entered and cleaned using epi data version 3.1 and all statistical tests were done using SPSS 20 software. RESULTS: The prevalence of overweight, obesity, and combined overweight/obesity was 16.6%, 4.2%, and 20.8%, respectively. The overall prevalence of PIU was 56.3%. After adjusting for confounders, adolescents with mild (AOR = 8.84; 95%CI: 2.99-26.10), moderate (AOR = 8.65; 95%CI: 2.81-26.62), and severe (AOR = 3.97; 95%CI: 1.36-11.57) PIU had significantly higher odds of overweight/obesity compared to those with normal internet use. Skipping breakfast, low physical activity, and high sedentary time were also significant independent risk factors. CONCLUSION AND RECOMMENDATION: The study reveals a high prevalence of PIU and a strong, graded association between PIU severity and overweight/obesity among in-school adolescents in Addis Ababa. Parents should encourage their children for managing their children's internet use and promoting healthier lifestyles at home. FAU - Abera, Melkamu AU - Abera M AD - Department of Nutrition and Dietetics, School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia. gariabera@gmail.com. FAU - Haidar, Jemal AU - Haidar J AD - Department of Nutrition and Dietetics, School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia. FAU - Shikur, Bilal AU - Shikur B AD - Department of Nutrition and Dietetics, School of Public Health, Addis Ababa University, Addis Ababa, Ethiopia. LA - eng PT - Journal Article DEP - 20260307 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC13081461 OTO - NOTNLM OT - Adolescents OT - Internet OT - Internet use OT - Obesity OT - Overweight OT - Problematic internet use COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/03/07 01:37 MHDA- 2026/03/07 01:38 PMCR- 2026/03/07 CRDT- 2026/03/06 23:47 PHST- 2025/08/05 00:00 [received] PHST- 2026/02/28 00:00 [accepted] PHST- 2026/03/07 01:38 [medline] PHST- 2026/03/07 01:37 [pubmed] PHST- 2026/03/06 23:47 [entrez] PHST- 2026/03/07 00:00 [pmc-release] AID - 10.1186/s40795-026-01295-3 [pii] AID - 1295 [pii] AID - 10.1186/s40795-026-01295-3 [doi] PST - epublish SO - BMC Nutr. 2026 Mar 7;12(1):69. doi: 10.1186/s40795-026-01295-3. PMID- 41792680 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Mar 7 TI - Nutritional status and associated factors in Ethiopian children with congenital heart disease: a systematic review and meta - analysis. LID - 10.1186/s12887-026-06707-8 [doi] LID - 315 AB - BACKGROUND: In low-resource settings like Ethiopia, Congenital Heart Disease is frequently complicated by a high yet poorly defined burden of malnutrition. To address this gap, this systematic review and meta-analysis aimed to rigorously quantify the pooled prevalence of undernutrition and identify determinants driving this condition among affected Ethiopian children. METHODS: Adhering to PRISMA guidelines and a prospective registration, this systematic review and meta-analysis included non-randomized studies reporting on malnutrition in Ethiopian children with congenital heart disease, which were identified through a comprehensive search of PubMed, Medline, HINARI, ScienceDirect, Scopus and Google Scholar up to November 15, 2025. The risk of bias was appraised using the Newcastle-Ottawa Scale, and data synthesis was performed in Stata version 17 using a random-effects meta-analysis to calculate pooled prevalence and Odds Ratios with 95% Confidence Intervals. Heterogeneity was quantified using the I2 statistic, while the robustness of the findings was evaluated through subgroup and leave-one-out sensitivity analyses. To address publication bias identified via funnel plot asymmetry, a non-parametric trim-and-fill analysis was applied to generate a more robust adjusted pooled prevalence, with forest plots utilized to visualize all individual and aggregate results. RESULTS: A total of 1,849 children across seven studies were included in the analysis. The overall pooled prevalence of undernutrition among Ethiopian children with CHD was estimated at 44.48% (95% CI: 38.44% - 50.52%, I2 = 95.3%). Significant associated factors for undernutrition were the presence of heart failure (OR = 4.12, 95% CI: 3.74-4.50, I2 = 4.2%), pulmonary hypertension (OR = 2.53, 95% CI: 1.93-3.13, I2 = 89.1%) & comorbidities (OR = 1.39, 95% CI: 1.25-1.54, I2 = 93%). CONCLUSION: Undernutrition impacts approximately 45% of Ethiopian children with congenital heart disease, primarily driven by clinical challenges like heart failure and pulmonary hypertension, which necessitates a shift toward integrated, multidisciplinary pediatric care. However, the reliability of this prevalence rate is undermined by significant statistical heterogeneity and the non-randomized nature of existing research, creating a high risk of bias and limited generalizability. To address these critical limitations, it is recommended that both clinical and research frameworks adopt standardized malnutrition diagnostic criteria and more rigorous study designs to ensure that future interventions are based on consistent, high-quality data rather than fragmented estimates. TRIAL REGISTRATION: CRD420251230006. FAU - Yirdaw, Berhanu Wale AU - Yirdaw BW AUID- ORCID: 0000-0003-0489-9634 AD - Department of Pediatrics and Child Health Nursing, Teda Health Science College, P.O.BOX: 790, Gondar, Amhara, Ethiopia. berhanuwale7@gmail.com. FAU - Agmas, Maritu Ayalew AU - Agmas MA AD - Department of Midwifery, Teda Health Science College, Gondar, Amhara, Ethiopia. FAU - Mekonen, Fasika Alemu AU - Mekonen FA AD - Department of Midwifery, Teda Health Science College, Gondar, Amhara, Ethiopia. FAU - Worku, Seferash Yohannes AU - Worku SY AD - Department of Midwifery, Teda Health Science College, Gondar, Amhara, Ethiopia. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260307 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Ethiopia/epidemiology MH - *Heart Defects, Congenital/complications/epidemiology MH - *Nutritional Status MH - Prevalence MH - *Malnutrition/epidemiology MH - Child MH - Risk Factors PMC - PMC13081370 OTO - NOTNLM OT - Associated Factors OT - Children OT - Congenital Heart Disease OT - Ethiopia OT - Nutritional Status COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/07 01:38 MHDA- 2026/06/27 12:39 PMCR- 2026/03/07 CRDT- 2026/03/06 23:38 PHST- 2025/12/12 00:00 [received] PHST- 2026/03/02 00:00 [accepted] PHST- 2026/06/27 12:39 [medline] PHST- 2026/03/07 01:38 [pubmed] PHST- 2026/03/06 23:38 [entrez] PHST- 2026/03/07 00:00 [pmc-release] AID - 10.1186/s12887-026-06707-8 [pii] AID - 6707 [pii] AID - 10.1186/s12887-026-06707-8 [doi] PST - epublish SO - BMC Pediatr. 2026 Mar 7;26(1):315. doi: 10.1186/s12887-026-06707-8. PMID- 41792652 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Mar 6 TI - Diagnostic accuracy of mid-upper arm circumference-for-age Z-score (MUACZ) for detecting malnutrition in children with cerebral palsy: a cross-sectional study. LID - 10.1186/s12887-026-06639-3 [doi] LID - 306 AB - BACKGROUND: Malnutrition is common in children with cerebral palsy (CP) due to feeding difficulties, altered body composition, and functional limitations, making an accurate nutritional assessment essential. The mid-upper arm circumference-for-age Z-score (MUACZ) is a practical screening tool, yet its diagnostic performance across childhood and adolescence remains insufficiently defined. The objective of this study was to assess the prevalence of undernutrition in children suffering from CP as well as the diagnostic performance of MUACZ in comparison with other anthropometric indicators across different age groups. METHODS: This cross-sectional study included 81 children with CP aged 2-18 years. Nutritional status was assessed using BMI-for-age (BAZ), height-for-age (HAZ), and MUACZ. Functional severity was classified using validated systems (GMFCS and EDACS). The diagnostic accuracy of MUACZ was evaluated with ROC analysis, and predictors of undernutrition were identified using multivariate logistic regression. RESULTS: Undernutrition (BAZ or HAZ /=6 years) groups. RESULTS: In the total population, older age, male sex, higher tonsil grade, and higher BMI percentile were positively associated with AHI. Subgroup analysis revealed that tonsil grade was the only significant predictor of AHI in the preschool-aged group. In the school-aged group, age and BMI percentile emerged as additional predictors of AHI, whereas the influence of tonsil grade, though still significant, was reduced. CONCLUSIONS: Older age, male sex, tonsillar hypertrophy, and obesity were significant predictors of AHI in children. Tonsillar hypertrophy played a more prominent role in younger children, while the influence of age and BMI percentile increased in older children. These findings highlight the importance of age-tailored evaluation in assessing OSA risk in pediatric populations. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Choi, Hosung AU - Choi H AD - Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea. FAU - Choi, Yohan AU - Choi Y AD - Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea. FAU - Park, Chan-Soon AU - Park CS AD - Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea. FAU - Kim, Sung Won AU - Kim SW AD - Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea. FAU - Kim, Soo Whan AU - Kim SW AD - Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea. FAU - Kim, Byung Guk AU - Kim BG AD - Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea. FAU - Lee, Dong Chang AU - Lee DC AD - Department of Otorhinolaryngology Head and Neck Surgery, College of Medicine, The Catholic University of Korea, Seoul, 06591, Republic of Korea. Electronic address: gadori@catholic.ac.kr. LA - eng PT - Journal Article DEP - 20260302 PL - Ireland TA - Int J Pediatr Otorhinolaryngol JT - International journal of pediatric otorhinolaryngology JID - 8003603 SB - IM MH - Humans MH - *Sleep Apnea, Obstructive/diagnosis/epidemiology/etiology MH - Male MH - Child MH - Polysomnography/methods MH - Child, Preschool MH - Retrospective Studies MH - Female MH - Body Mass Index MH - *Palatine Tonsil/pathology MH - Age Factors MH - Risk Factors MH - Sex Factors MH - Severity of Illness Index MH - Hypertrophy MH - Predictive Value of Tests MH - Adenoids/pathology MH - Obesity/complications MH - Risk Assessment OTO - NOTNLM OT - Child OT - Palatine tonsil OT - Polysomnography OT - Risk factors OT - Sleep apnea syndromes COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/07 01:37 MHDA- 2026/03/17 00:33 CRDT- 2026/03/06 18:09 PHST- 2025/12/21 00:00 [received] PHST- 2026/03/01 00:00 [accepted] PHST- 2026/03/17 00:33 [medline] PHST- 2026/03/07 01:37 [pubmed] PHST- 2026/03/06 18:09 [entrez] AID - S0165-5876(26)00068-6 [pii] AID - 10.1016/j.ijporl.2026.112773 [doi] PST - ppublish SO - Int J Pediatr Otorhinolaryngol. 2026 Apr;203:112773. doi: 10.1016/j.ijporl.2026.112773. Epub 2026 Mar 2. PMID- 41791201 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260803 IS - 1878-0539 (Electronic) IS - 1748-6815 (Linking) VI - 115 DP - 2026 Apr TI - Two-staged tubercle plasty using a banked prolabial vermilion island flap for bilateral cleft lip. PG - 123-129 LID - S1748-6815(26)00093-8 [pii] LID - 10.1016/j.bjps.2026.02.022 [doi] AB - BACKGROUND: We evaluated the effectiveness of a novel two-staged tubercle plasty method utilizing banked vermilion tissue of the prolabium to reconstruct a natural and esthetically pleasing median tubercle in patients with bilateral cleft lip. METHODS: A retrospective observational study was conducted on 20 patients (13 boys and 7 girls) with bilateral cleft lip who underwent primary cheiloplasty with oral-side banking of the prolabial vermilion at our institution between 2009 and 2024. At preschool age (5-6 years), a second-stage tubercle plasty was performed in conjunction with secondary alveolar bone grafting. Anthropometric measurements (philtral height, vermilion height of the upper lip, and total labial height) were assessed pre- and postoperatively and compared with age-matched normal controls. The morphology of the upper lip and degree of wet vermilion exposure were evaluated on a four-point scale (excellent, good, fair, and poor) before and after the revision surgery. RESULTS: All patients underwent successful procedures without complications. The vermilion and total labial heights were significantly increased (both p=0.031), while philtral height remained unchanged. At 6-131 months of follow-up, lip morphology was significantly improved (p=0.021) and wet vermilion exposure was reduced (p=0.008). CONCLUSION: Two-staged tubercle plasty using banked vermilion tissue of the prolabium is an effective technique for correcting an upward convex deformity of the upper lip in patients with bilateral cleft lip. This method preserves native lip tissue during the primary repair and allows for natural median tubercle construction at a later stage. Additional studies with larger cohorts and long-term follow-up are warranted to validate these findings. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Tsunekawa, Kazuhiro AU - Tsunekawa K AD - Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan. Electronic address: tsune@shinshu-u.ac.jp. FAU - Nagai, Fumio AU - Nagai F AD - Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan. FAU - Yaguchi, Kiichiro AU - Yaguchi K AD - Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan. FAU - Yuzuriha, Shunsuke AU - Yuzuriha S AD - Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano 390-8621, Japan. LA - eng PT - Journal Article PT - Observational Study DEP - 20260216 PL - Netherlands TA - J Plast Reconstr Aesthet Surg JT - Journal of plastic, reconstructive & aesthetic surgery : JPRAS JID - 101264239 SB - IM MH - Humans MH - *Cleft Lip/surgery MH - Female MH - Retrospective Studies MH - Child, Preschool MH - *Plastic Surgery Procedures/methods MH - Male MH - *Surgical Flaps MH - Child MH - *Lip/surgery MH - Treatment Outcome OTO - NOTNLM OT - Cleft lip OT - Esthetics OT - Lip deformities OT - Reconstructive surgical procedures OT - Surgical flaps OT - Two-staged tubercle reconstruction COIS- Declaration of Competing Interest The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/03/07 01:37 MHDA- 2026/04/09 00:34 CRDT- 2026/03/06 18:02 PHST- 2025/10/30 00:00 [received] PHST- 2026/02/01 00:00 [revised] PHST- 2026/02/11 00:00 [accepted] PHST- 2026/04/09 00:34 [medline] PHST- 2026/03/07 01:37 [pubmed] PHST- 2026/03/06 18:02 [entrez] AID - S1748-6815(26)00093-8 [pii] AID - 10.1016/j.bjps.2026.02.022 [doi] PST - ppublish SO - J Plast Reconstr Aesthet Surg. 2026 Apr;115:123-129. doi: 10.1016/j.bjps.2026.02.022. Epub 2026 Feb 16. PMID- 41790756 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 3 DP - 2026 TI - Association between obesity and neurodevelopmental delay risk in children under five years: A study from Tumbes, Peru. PG - e0343815 LID - 10.1371/journal.pone.0343815 [doi] LID - e0343815 AB - BACKGROUND: Childhood obesity is an emerging public health concern in low- and middle-income countries and may be associated with early neurodevelopmental vulnerability. Evidence on this association during early childhood remains limited, particularly in Latin American settings. OBJECTIVE: To evaluate the association between childhood obesity and neurodevelopmental delay risk in children under five years of age attending public healthcare facilities in Tumbes, Peru, and to develop a multivariable nomogram for probabilistic risk estimation. METHODS: An analytical cross-sectional study was conducted between 2022 and 2024 among children aged 0-59 months receiving care at two EsSalud healthcare facilities in Tumbes. Neurodevelopment was assessed using the Evaluacion del Desarrollo Infantil (EDI), classifying children as having normal development, developmental lag, or being at risk of developmental delay. Childhood obesity was defined using WHO weight-for-height standards. Sociodemographic, clinical, and behavioral variables were collected. Associations were evaluated using proportional odds ordinal logistic regression guided by a directed acyclic graph. A nomogram was developed based on the final model and internally validated using bootstrap resampling (1,000 iterations). RESULTS: The final analytical sample included 431 children; 27% were classified as obese and 19% had anemia. According to the EDI, 58% had normal development, 36% developmental lag, and 6% were at risk of developmental delay. Childhood obesity was independently associated with higher cumulative odds of neurodevelopmental delay risk (OR = 2.73; 95% CI: 1.66-4.51). Male sex and older age group were also associated with increased risk, while higher caregiver knowledge of complementary feeding showed a protective association. Physical activity compliance and anemia were not independently associated in the multivariable model. The nomogram demonstrated acceptable internal discrimination (AUC > 0.7). CONCLUSIONS: Childhood obesity was associated with increased neurodevelopmental delay risk in children under five years of age. An explanation-informed nomogram using routinely available variables may support early risk stratification in primary care, although external validation is required before broader implementation. CI - Copyright: (c) 2026 Arredondo-Nontol et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Arredondo-Nontol, Miriam AU - Arredondo-Nontol M AUID- ORCID: 0000-0001-6269-7593 AD - Hospital Carlos Alberto Cortez Jimenez Essalud Tumbes, Tumbes, Peru. AD - Universidad Nacional de Tumbes, Tumbes, Peru. FAU - Arredondo-Nontol, Rodolfo AU - Arredondo-Nontol R AD - Hospital Carlos Alberto Cortez Jimenez Essalud Tumbes, Tumbes, Peru. AD - Universidad Nacional de Tumbes, Tumbes, Peru. FAU - Reto, Narcisa AU - Reto N AUID- ORCID: 0000-0002-8107-1657 AD - Hospital Carlos Alberto Cortez Jimenez Essalud Tumbes, Tumbes, Peru. AD - Universidad Cesar Vallejo, Piura, Peru. FAU - Murillo Carrasco, Alexis German AU - Murillo Carrasco AG AD - Instituto de Evaluacion de Tecnologias en Salud e Investigacion - IETSI, Seguro Social de Salud - EsSalud, Lima, Peru. AD - Organization for Medical Innovation and Collaboration for Sciences-OMICS, Lima, Peru. LA - eng PT - Journal Article DEP - 20260306 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Peru/epidemiology MH - Male MH - Child, Preschool MH - Infant MH - Cross-Sectional Studies MH - Female MH - *Pediatric Obesity/epidemiology/complications MH - Risk Factors MH - Infant, Newborn MH - *Developmental Disabilities/epidemiology MH - *Neurodevelopmental Disorders/epidemiology PMC - PMC12965558 COIS- The authors have declared that no competing interests exist. EDAT- 2026/03/06 19:43 MHDA- 2026/03/08 06:38 PMCR- 2026/03/06 CRDT- 2026/03/06 13:42 PHST- 2025/06/10 00:00 [received] PHST- 2026/02/11 00:00 [accepted] PHST- 2026/03/08 06:38 [medline] PHST- 2026/03/06 19:43 [pubmed] PHST- 2026/03/06 13:42 [entrez] PHST- 2026/03/06 00:00 [pmc-release] AID - PONE-D-25-30834 [pii] AID - 10.1371/journal.pone.0343815 [doi] PST - epublish SO - PLoS One. 2026 Mar 6;21(3):e0343815. doi: 10.1371/journal.pone.0343815. eCollection 2026. PMID- 41790171 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1590-1262 (Electronic) IS - 1124-4909 (Print) IS - 1124-4909 (Linking) VI - 31 IP - 1 DP - 2026 Mar 6 TI - Psychometric properties of shortened versions of the Eating Disorder Examination-Questionnaire in Brazilian women. LID - 10.1007/s40519-026-01835-7 [doi] LID - 30 AB - OBJECTIVE: The Eating Disorder Examination-Questionnaire (EDE-Q) is a widely used 28-item instrument for screening eating disorders, of which 22 are attitudinal items used to compute subscale scores and to assess factorial structure, while six open-ended items assess behavioral frequency and are excluded from dimensional analyses. Shorter versions, such as the EDE-Q7, EDE-Q8, and EDE-Q18, have been proposed to enhance accessibility and psychometric properties. This study aimed to evaluate different factorial structures of the EDE-Q and identify the model that best fits a sample of Brazilian adult women. METHODS: A total of 712 women completed the EDE-Q and measures of body satisfaction and sociocultural pressures. The factorial structure was analyzed through confirmatory factor analysis (CFA), and convergent validity and internal consistency were also assessed. RESULTS: The multifactorial structure of the original EDE-Q and the 18-item model did not fit the sample well. Although the 7-item model showed acceptable fit, the 8-item version demonstrated the best fit. The EDE-Q8 factors showed a negative association with appearance evaluation and body area satisfaction, and a positive association with internalization of the thin and muscular body ideal and body mass index. Internal consistency was adequate. CONCLUSION: The 8-item short version of the EDE-Q is a reliable and practical psychometric tool for assessing disordered eating behaviors in Brazilian adult women. Future studies should explore the psychometric performance of the EDE-Q8 across different age ranges, gender groups, and clinical populations to strengthen evidence for its cross-cultural validity and generalizability. LEVEL OF EVIDENCE: Level III, well-designed cohort or case-control analytic studies. CI - (c) 2026. The Author(s). FAU - Goncalves, Andreia Dutra AU - Goncalves AD AUID- ORCID: 0009-0005-9627-5790 AD - Department of Psychology, Faculty of Philosophy, Sciences, and Letters of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil. FAU - Bagolin, Vitoria AU - Bagolin V AUID- ORCID: 0009-0006-8641-8839 AD - Department of Psychology, Faculty of Philosophy, Sciences, and Letters of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil. FAU - de Carvalho, Pedro Henrique Berbert AU - de Carvalho PHB AUID- ORCID: 0000-0002-4918-5080 AD - NICTA, Body Image and Eating Disorders Research Group, Federal University of Juiz de Fora, Governador Valadares, Brazil. FAU - Laus, Maria Fernanda AU - Laus MF AUID- ORCID: 0000-0002-4947-1642 AD - Department of Psychology, Faculty of Philosophy, Sciences, and Letters of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil. mflaus@usp.br. AD - Department of Health Sciences, Ribeirao Preto Medical School, University of Sao Paulo, Avenida Bandeirantes, 3900, Vila Monte Alegre, Ribeirao Preto, SP, 14040900, Brazil. mflaus@usp.br. LA - eng GR - 130348/2025-2/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/ GR - 2024/08757-8/Fundacao de Amparo a Pesquisa do Estado de Sao Paulo/ GR - 88887.955259/2024-00/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ PT - Journal Article DEP - 20260306 PL - Germany TA - Eat Weight Disord JT - Eating and weight disorders : EWD JID - 9707113 SB - IM MH - Humans MH - Female MH - *Feeding and Eating Disorders/diagnosis/psychology MH - Psychometrics MH - Brazil MH - Adult MH - Surveys and Questionnaires MH - Reproducibility of Results MH - *Body Image/psychology MH - Factor Analysis, Statistical MH - Young Adult MH - Body Satisfaction MH - Adolescent MH - Middle Aged MH - Body Mass Index PMC - PMC13079533 OTO - NOTNLM OT - Assessment OT - Brazil OT - Disordered eating OT - EDE-Q OT - Factor analysis OT - Psychometrics COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/03/06 13:46 MHDA- 2026/04/14 12:35 PMCR- 2026/03/06 CRDT- 2026/03/06 11:04 PHST- 2025/07/12 00:00 [received] PHST- 2026/02/27 00:00 [accepted] PHST- 2026/04/14 12:35 [medline] PHST- 2026/03/06 13:46 [pubmed] PHST- 2026/03/06 11:04 [entrez] PHST- 2026/03/06 00:00 [pmc-release] AID - 10.1007/s40519-026-01835-7 [pii] AID - 1835 [pii] AID - 10.1007/s40519-026-01835-7 [doi] PST - epublish SO - Eat Weight Disord. 2026 Mar 6;31(1):30. doi: 10.1007/s40519-026-01835-7. PMID- 41789750 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1307-7945 (Electronic) IS - 1306-696X (Print) IS - 1306-696X (Linking) VI - 32 IP - 2 DP - 2026 Feb TI - The effect of blood urea nitrogen (BUN)/albumin ratio in evaluating mortality in pediatric burn patients with 20% or greater total body surface area involvement. PG - 152-158 LID - 10.14744/tjtes.2025.60209 [doi] AB - BACKGROUND: This study aims to evaluate the predictive value of the blood urea nitrogen (BUN)/albumin ratio for in-hospital mortality in pediatric burn patients with a total body surface area (TBSA) of 20% or greater and to compare its performance with established scoring systems, namely the Abbreviated Burn Severity Index (ABSI) and the Pediatric Baux Score (P-Baux). METHODS: Patients hospitalized with burns involving 20% or greater TBSA in our pediatric burn unit between 2018 and 2023 were reviewed retrospectively. Patients were analyzed for demographic information, basic clinical data, cause of burn, operative interventions, ABSI and P-Baux scores and the follow-up period. The BUN/albumin ratio was calculated using BUN and albumin values measured at the time of index hospital admission. Data were evaluated for in-hospital mortality. RESULTS: A total of 212 patients were included in the study. Patients were divided into two groups: survivors and non-survivors. The non-survivor group had significantly higher TBSA involvement, full-thickness burns, inhalation injuries, and operative requirements (p<0.001). The overall mortality rate was 4.5%. Receiver operating characteristic (ROC) analysis demonstrated that the BUN/albumin ratio is a strong predictor of in-hospital mortality, with predictive power similar to that of the ABSI and P-Baux scores. The cut-off value for mortality prediction using the BUN/albumin ratio was >5.24. CONCLUSION: The BUN/albumin ratio is a simple and easily accessible marker that demonstrates strong statistical value in predicting in-hospital mortality in pediatric patients with burns covering 20% or more of the body. Given its availability from routine blood tests, we believe it may serve as a practical and helpful tool for clinicians caring for pediatric burn patients. FAU - Payza, Ayse Demet AU - Payza AD AD - Department of Pediatric Surgery, Health Sciences University, Dr. Behcet Uz Pediatric Diseases and Surgery Training and Research Hospital, Izmir-Turkiye. FAU - Boztas, Asya Eylem AU - Boztas AE AD - Department of Pediatric Surgery, Health Sciences University, Dr. Behcet Uz Pediatric Diseases and Surgery Training and Research Hospital, Izmir-Turkiye. FAU - Oral, Akgun AU - Oral A AD - Department of Pediatric Surgery, Health Sciences University, Dr. Behcet Uz Pediatric Diseases and Surgery Training and Research Hospital, Izmir-Turkiye. LA - eng PT - Journal Article TT - %20 ve uzeri yanik alani olan pediatrik hastalarda mortaliteyi degerlendirmede bun/albumin oraninin etkisi. PL - Turkey TA - Ulus Travma Acil Cerrahi Derg JT - Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES JID - 101274231 RN - 0 (Serum Albumin) SB - IM MH - Humans MH - *Burns/mortality/blood MH - *Blood Urea Nitrogen MH - Female MH - Male MH - Body Surface Area MH - Retrospective Studies MH - Child, Preschool MH - Child MH - Infant MH - *Hospital Mortality MH - *Serum Albumin/analysis MH - Adolescent MH - Turkey/epidemiology MH - Predictive Value of Tests PMC - PMC13063235 COIS- None declared. EDAT- 2026/03/06 13:45 MHDA- 2026/03/06 19:44 PMCR- 2026/02/09 CRDT- 2026/03/06 07:32 PHST- 2026/03/06 19:44 [medline] PHST- 2026/03/06 13:45 [pubmed] PHST- 2026/03/06 07:32 [entrez] PHST- 2026/02/09 00:00 [pmc-release] AID - TJTES-32-152 [pii] AID - 10.14744/tjtes.2025.60209 [doi] PST - ppublish SO - Ulus Travma Acil Cerrahi Derg. 2026 Feb;32(2):152-158. doi: 10.14744/tjtes.2025.60209. PMID- 41789472 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260721 IS - 1938-744X (Electronic) IS - 1935-7893 (Linking) VI - 20 DP - 2026 Mar 6 TI - Development of a Sustainable Blended Food Aid Product Using Local Ingredients for Nutritionally Vulnerable Populations in Haiti. PG - e54 LID - 10.1017/dmp.2026.10321 [doi] AB - OBJECTIVES: This study aimed to: (1) identify optimal blended food recipe options using local flours; (2) assess behaviors, attitudes, and practices around the use of blended foods among nutritionally vulnerable groups in Haiti; and (3) evaluate the nutrient composition of prototype blended food product relative to nutrient requirements for vulnerable populations. METHODS: Blended food recipes made from local flours were identified through matrix scoring and stakeholder consensus. Focus groups (n = 7) assessed behaviors and attitudes toward blended foods. Prototype recipes were selected based on matrix scoring, program participant feedback, and feasibility of bringing to scale. Nutrient composition of the final prototype was analyzed for consumer information and compared to requirements for young children and pregnant/lactating women. RESULTS: Two food prototypes resulted. Only the sweet blended food product could be scaled for testing due to the lack of availability of fish for the savory recipe. Focus groups highlighted positive views on balanced nutrition and healthy eating but raised concerns about costs and safety. Nutrient composition analysis of the final prototype showed varying proportions of requirements attained across nutrients. CONCLUSIONS: Blended foods made from Haitian-grown ingredients and food aid offer promise to improve nutrition for target populations but face challenges in scaling to market. FAU - Jean Louis Dulience, Sherlie AU - Jean Louis Dulience S AD - School of Public Health, https://ror.org/01yc7t268Washington University in St Louis, St Louis, MO, USA. FAU - Zimmerman, Rachel AU - Zimmerman R AUID- ORCID: 0009-0007-3417-1552 AD - School of Public Health, https://ror.org/01yc7t268Washington University in St Louis, St Louis, MO, USA. FAU - Dorce, Michelle AU - Dorce M AD - School of Public Health, https://ror.org/01yc7t268Washington University in St Louis, St Louis, MO, USA. FAU - Seff, Ilana AU - Seff I AD - School of Public Health, https://ror.org/01yc7t268Washington University in St Louis, St Louis, MO, USA. FAU - Spray Bulungu, Andrea AU - Spray Bulungu A AD - Brown School, https://ror.org/01yc7t268Washington University in St Louis, St Louis, MO, USA. FAU - Kohl, Patricia AU - Kohl P AD - Brown School, https://ror.org/01yc7t268Washington University in St Louis, St Louis, MO, USA. AD - Division of Child and Adolescent Psychiatry, https://ror.org/01yc7t268Washington University School of Medicine in Saint Louis, St Louis, MO, USA. FAU - Lesorogol, Carolyn AU - Lesorogol C AD - Brown School, https://ror.org/01yc7t268Washington University in St Louis, St Louis, MO, USA. FAU - Dulience, Bazelais AU - Dulience B AD - https://ror.org/007h7f935Campus Henri de l'Universite d'Etat d'Haiti, a Limonade, Limonade, Nord, Haiti. FAU - Iannotti, Lora AU - Iannotti L AD - School of Public Health, https://ror.org/01yc7t268Washington University in St Louis, St Louis, MO, USA. LA - eng GR - FAIN No. 720BHA22CA00003/United States Agency for International Development/ PT - Journal Article DEP - 20260306 PL - United States TA - Disaster Med Public Health Prep JT - Disaster medicine and public health preparedness JID - 101297401 SB - IM MH - Haiti MH - Humans MH - Focus Groups/methods MH - *Vulnerable Populations/statistics & numerical data MH - *Food Assistance/standards/statistics & numerical data/trends MH - Female MH - Food, Processed OTO - NOTNLM OT - Haiti OT - food aid OT - locally sourced ingredients OT - public health nutrition EDAT- 2026/03/06 09:09 MHDA- 2026/03/07 18:38 CRDT- 2026/03/06 05:12 PHST- 2026/03/07 18:38 [medline] PHST- 2026/03/06 09:09 [pubmed] PHST- 2026/03/06 05:12 [entrez] AID - S1935789326103218 [pii] AID - 10.1017/dmp.2026.10321 [doi] PST - epublish SO - Disaster Med Public Health Prep. 2026 Mar 6;20:e54. doi: 10.1017/dmp.2026.10321. PMID- 41788955 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260306 LR - 20260813 IS - 2277-9531 (Print) IS - 2319-6440 (Electronic) IS - 2277-9531 (Linking) VI - 15 DP - 2026 TI - Effectiveness of parenting education modules in enhancing knowledge of positive discipline and child development among mothers. PG - 31 LID - 10.4103/jehp.jehp_166_25 [doi] LID - 31 AB - BACKGROUND: The early childhood period is critical for physical, cognitive, and emotional development. However, many young children face developmental challenges due to malnutrition, insufficient parental education, and lack of adequate care. These factors can impede children's ability to achieve age-appropriate developmental milestones. Providing parents, particularly mothers, with training on child development can significantly improve child growth and development outcomes. This study aimed to evaluate the effectiveness of a parenting education program designed to enhance maternal knowledge regarding child developmental milestones and delays among mothers of infants attending selected urban immunization centers. METHODS: A quasi-experimental, one-group pre-test post-test research design was employed to assess the impact of a parenting education program on maternal knowledge. A total of 89 mothers of infants aged 2-12 months were selected using purposive sampling from urban immunization centers. Participants were provided with structured parenting education sessions focused on child development, including the identification of developmental milestones and potential developmental delays. Pre- and post-intervention knowledge levels of mothers were measured using a pre-validated, structured questionnaire, which assessed their understanding of child growth and development. RESULTS: The pre-test mean score for maternal knowledge was 14.8 (SD = 3.2), indicating a moderate level of awareness regarding child development. After completing the parenting education program, the post-test mean score increased to 22.7 (SD = 3.5), reflecting a significant improvement in knowledge. A paired t-test was used to compare the pre-test and post-test scores, revealing a calculated t-value of 22.06. This was compared with the tabulated t-value of 1.98 at 88 degrees of freedom (P < 0.05), supporting the hypothesis that the intervention had a statistically significant impact on maternal knowledge. The results demonstrated that the parenting education program effectively improved the mothers' understanding of child developmental milestones and delays. CONCLUSIONS: The findings of this study suggest that parenting education programs are a valuable tool in enhancing maternal knowledge of child development. By increasing awareness about developmental milestones and delays, such programs empower mothers to recognize early signs of developmental issues and provide appropriate care to support their child's growth. The study highlights the importance of integrating parenting education into public health initiatives, particularly in urban immunization centers, to address gaps in knowledge and foster better outcomes for both children and families. Given the significant improvements observed in maternal knowledge, it is recommended that similar parenting education programs be scaled up and integrated into regular healthcare services, ensuring that mothers across diverse settings have access to essential information that can positively influence child development. CI - Copyright: (c) 2026 Journal of Education and Health Promotion. FAU - Sharma, Anjali AU - Sharma A AD - Department of Nursing, College of Nursing, Rajarshi Dashrath Autonomous State Medical College, Ayodhya, Uttar Pradesh, India. FAU - Kumar, Rohitash AU - Kumar R AD - Department of Nursing, KGMU College of Nursing, King George's Medical University, Lucknow, Uttar Pradesh, India. FAU - Singh, S K AU - Singh SK AD - Department of Community Medicine, King George Medical University, Lucknow, Uttar Pradesh, India. LA - eng PT - Journal Article DEP - 20260130 PL - India TA - J Educ Health Promot JT - Journal of education and health promotion JID - 101593794 PMC - PMC12959543 OTO - NOTNLM OT - Child development OT - developmental delays OT - developmental milestones OT - early childhood development OT - parenting education COIS- There are no conflicts of interest. EDAT- 2026/03/06 09:03 MHDA- 2026/03/06 09:04 PMCR- 2026/01/30 CRDT- 2026/03/06 04:51 PHST- 2025/01/25 00:00 [received] PHST- 2025/05/27 00:00 [accepted] PHST- 2026/03/06 09:04 [medline] PHST- 2026/03/06 09:03 [pubmed] PHST- 2026/03/06 04:51 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - JEHP-15-31 [pii] AID - 10.4103/jehp.jehp_166_25 [doi] PST - epublish SO - J Educ Health Promot. 2026 Jan 30;15:31. doi: 10.4103/jehp.jehp_166_25. eCollection 2026. PMID- 41788529 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Trends in 4th-12th grade students' aerobic capacity and muscular strength and endurance: New York City public school students, 2006-2019. PG - 1682913 LID - 10.3389/fpubh.2026.1682913 [doi] LID - 1682913 AB - BACKGROUND: Systematically monitoring youth fitness over time is critical for designing and implementing policies and interventions to maintain/increase youth fitness and reduce the burden of non-communicable disease. This study describes trends in student fitness over school years 2006/07-2018/19, the longest period for which US-based data are available. METHODS: This observational, longitudinal study uses 13 years of population-weighted data from the New York City (NYC) FITNESSGRAM from 2,272,575 unique students (8,523,877 student-year observations) in 4th-12th grades from 1,721 public schools. Sex-and age-specific performance was assessed using healthy fitness zones (HFZ), validated performance standards indicating whether individual fitness was sufficient for good overall health. Adjusted generalized estimating equations determined the prevalence of being in the HFZ for aerobic capacity, push-ups, and curl-ups for all students, and by student sex, grade level, race/ethnicity, and home neighborhood socioeconomic status (SES). RESULTS: In 2006/07, 24.7% of students were in the HFZ for aerobic capacity, 55.3% for push-ups, and 65.0% for curl-ups. By 2018-19, 35.6% were in the HFZ for aerobic capacity (a relative increase of 44.1% from baseline; p < 0.001); 56.1% (SD = 0.56) for push-ups (1.4% relative increase; p < 0.001); and 70.5% (SD = 0.54) for curl-ups (8.5% relative increase; p < 0.001). Stratified models demonstrated persistent differences in the proportion of students in the HFZ by sex, school level, and home neighborhood SES. Gaps between non-Hispanic White compared to non-Hispanic Black and Hispanic students grew slightly. CONCLUSION: Thirteen years of data from the largest school district in the nation demonstrate overall improvements in student fitness performance on all three tests, with the largest gains seen for aerobic capacity. However, continued work is necessary to address persistent disparities in NYC youth aerobic capacity and muscular strength and endurance by sex, grade level, race/ethnicity, and socioeconomic status. CI - Copyright (c) 2026 Day, Nguyen, Argenio, Konty, Dougan, D'Agostino, Neshteruk, Wagner and Thompson. FAU - Day, Sophia AU - Day S AD - Office of School Health, Research and Analytics, New York City Department of Health and Mental Hygiene, New York, NY, United States. FAU - Nguyen, Caroline AU - Nguyen C AD - Department of Community Health Science, School of Public Health, University of California, Berkeley, Berkeley, CA, United States. FAU - Argenio, Kira AU - Argenio K AD - Office of School Health, Research and Analytics, New York City Department of Health and Mental Hygiene, New York, NY, United States. FAU - Konty, Kevin AU - Konty K AD - Office of School Health, Research and Analytics, New York City Department of Health and Mental Hygiene, New York, NY, United States. FAU - Dougan, Sydney S AU - Dougan SS AD - Department of Community Health Science, School of Public Health, University of California, Berkeley, Berkeley, CA, United States. FAU - D'Agostino, Emily AU - D'Agostino E AD - Department of Population Health Sciences and Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, United States. FAU - Neshteruk, Cody D AU - Neshteruk CD AD - Department of Population Health Sciences and Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, United States. FAU - Wagner, Brooke E AU - Wagner BE AD - Department of Population Health Sciences and Department of Orthopaedic Surgery, Duke University School of Medicine, Durham, NC, United States. FAU - Thompson, Hannah R AU - Thompson HR AD - Department of Community Health Science, School of Public Health, University of California, Berkeley, Berkeley, CA, United States. LA - eng PT - Journal Article PT - Observational Study DEP - 20260218 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - New York City MH - Longitudinal Studies MH - Female MH - Male MH - *Students/statistics & numerical data MH - *Physical Endurance/physiology MH - *Muscle Strength/physiology MH - Adolescent MH - *Physical Fitness/physiology MH - Schools MH - Child PMC - PMC12957200 OTO - NOTNLM OT - cardiorespiratory fitness (CRF) OT - elementary students OT - muscular endurance OT - muscular strength OT - secondary students COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/06 09:03 MHDA- 2026/03/08 01:37 PMCR- 2026/02/18 CRDT- 2026/03/06 04:47 PHST- 2025/08/09 00:00 [received] PHST- 2026/01/13 00:00 [revised] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/03/08 01:37 [medline] PHST- 2026/03/06 09:03 [pubmed] PHST- 2026/03/06 04:47 [entrez] PHST- 2026/02/18 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1682913 [doi] PST - epublish SO - Front Public Health. 2026 Feb 18;14:1682913. doi: 10.3389/fpubh.2026.1682913. eCollection 2026. PMID- 41788143 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260306 LR - 20260813 IS - 2757-8038 (Electronic) IS - 2757-8038 (Linking) VI - 27 IP - 1 DP - 2026 Feb TI - Prediction of Smartphone Addiction Among Korean Adolescents Based on Physical Activity and Mental Health: A Machine Learning Analysis Using LASSO and SHAP From the Korea Youth Risk Behavior Survey. PG - 46201 LID - 10.31083/AP46201 [doi] LID - 46201 AB - BACKGROUND: Adolescent smartphone overuse is associated with physical inactivity and mental health problems, such as anxiety. However, few studies have analyzed these factors jointly using both linear and non-linear methods. This study aimed to predict smartphone addiction using physical activity and mental health indicators from the 2020 and 2023 Korea Youth Risk Behavior Survey, applying Least Absolute Shrinkage and Selection Operator (LASSO), multiple machine learning models, and SHapley Additive exPlanations (SHAP) analysis. METHODS: A total of 86,744 adolescents were classified into general (n = 63,963), potential risk (n = 20,383), and high-risk (n = 2398) smartphone user groups. For the binary classification, general users were compared with combined-risk users. Twelve key predictors were selected using LASSO. Logistic Regression, Random Forest, Extreme Gradient Boosting (XGBoost), and Light Gradient Boosting Machine (LightGBM) models were implemented with Synthetic Minority Over-sampling Technique balancing; SHAP was used to compare variable importance across models. RESULTS: LASSO identified moderate physical activity (beta = -0.156), strength physical activity (-0.149), loneliness (0.144), smartphone usage time (0.085), and anxiety (0.078) as major predictors. Random Forest and Logistic Regression showed the best recall (0.63 and 0.60); LightGBM had the highest accuracy (0.726). It also achieved the highest Area Under the Receiver Operating Characteristic Curve (AUROC) (0.7108); XGBoost showed the lowest AUROC (0.5621). SHAP consistently ranked anxiety and smartphone usage time as the top predictors, with sleep and physical activity showing variable importance. CONCLUSIONS: Anxiety and smartphone usage time were consistently dominant predictors. Physical activity variables contributed in some models but showed inconsistent importance. These findings highlight the central role of mental health, with behavioral factors playing a secondary, model-specific role. CI - Copyright: (c) 2026 The Author(s). Published by IMR Press. FAU - Lee, Kihyuk AU - Lee K AUID- ORCID: 0000-0001-6717-7087 AD - Office of Hospital Information, Seoul National University Bundang Hospital, 13605 Seongnam, Republic of Korea. FAU - Seo, Wooin AU - Seo W AUID- ORCID: 0009-0002-6361-0458 AD - Office of Hospital Information, Seoul National University Bundang Hospital, 13605 Seongnam, Republic of Korea. FAU - Jung, Se Young AU - Jung SY AUID- ORCID: 0000-0001-9946-8807 AD - Office of Hospital Information, Seoul National University Bundang Hospital, 13605 Seongnam, Republic of Korea. AD - Department of Family Medicine, Seoul National University Bundang Hospital, 13620 Seongnam, Republic of Korea. AD - Department of Family Medicine, College of Medicine, Seoul National University, 03080 Seoul, Republic of Korea. LA - eng PT - Journal Article DEP - 20260226 PL - Singapore TA - Alpha Psychiatry JT - Alpha psychiatry JID - 9918284277106676 PMC - PMC12957968 OTO - NOTNLM OT - Least Absolute Shrinkage and Selection Operator (LASSO) OT - SHapley Additive exPlanations (SHAP) OT - adolescents OT - machine learning OT - mental health OT - physical activity OT - smartphone addiction COIS- The authors declare no conflict of interest. EDAT- 2026/03/06 09:05 MHDA- 2026/03/06 09:06 PMCR- 2026/02/26 CRDT- 2026/03/06 04:43 PHST- 2025/08/31 00:00 [received] PHST- 2025/11/11 00:00 [revised] PHST- 2025/11/17 00:00 [accepted] PHST- 2026/03/06 09:06 [medline] PHST- 2026/03/06 09:05 [pubmed] PHST- 2026/03/06 04:43 [entrez] PHST- 2026/02/26 00:00 [pmc-release] AID - S2757-8038(26)02183-0 [pii] AID - 10.31083/AP46201 [doi] PST - epublish SO - Alpha Psychiatry. 2026 Feb 26;27(1):46201. doi: 10.31083/AP46201. eCollection 2026 Feb. PMID- 41787318 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Mar 6 TI - Development of machine learning models for early prediction of small for-gestational-age births using maternal sociodemographic and obstetric data. LID - 10.1186/s12884-026-08906-8 [doi] LID - 333 AB - BACKGROUND: Small for gestational age (SGA) is a significant concern in obstetrics, with implications for stillbirth, neonatal mortality, and long-term health outcomes. The early detection of SGA is crucial for prevention and treatment, but current methods have limitations. This study aimed to develop a machine learning (ML) models-based algorithm to predict SGA using sociodemographic and obstetric features during the preconception period. METHODS: We retrospectively analyzed first-trimester attendees (1 Jan 2022-31 Dec 2023) and developed parity-stratified prediction models (nulliparous vs. primiparous) using routinely available sociodemographic and obstetric variables at the first prenatal visit. Five algorithms (logistic regression, random forest, XGBoost, LightGBM, and extra trees) were trained using an 80/20 stratified train-test split with 5-fold cross-validation. Model performance was assessed using AUC-ROC, accuracy, sensitivity, and specificity. Reporting was guided by TRIPOD + AI recommendations for prediction model development and validation. RESULTS: Among nulliparous women, logistic regression achieved accuracy 72.7% and AUC 0.733 (95% CI for accuracy 0.464-0.990). Among primiparous women, XGBoost achieved accuracy 80% and AUC 0.92 (95% CI for accuracy 0.552-1.000). Anthropometric variables (weight, BMI, height) and previous birth weight (primiparous) were most influential predictors. CONCLUSION: An ML model constructed with basic maternal sociodemographic findings and obstetric history may serve as an early prediction tool for SGA during the preconception period, particularly in resource-constrained settings, although broader validation is required. FAU - Butun, Zafer AU - Butun Z AD - Hosnudiye Mah, Aysen Sokak Dorya Rezidans, Eskisehir, Turkiye. zaferbutun@hotmail.com. FAU - Salik, Ece Akca AU - Salik EA AD - Department of Gynecology and Obstetrics, Eskisehir City Hospital, Eskisehir, Turkiye. FAU - Kaya, Yeliz AU - Kaya Y AD - Faculty of Health Sciences, Department of Gynecology and Obstetrics Nursing, Eskisehir Osmangazi University , Eskisehir, Turkiye. FAU - Celik, Ozer AU - Celik O AD - Faculty of Science, Department of Mathematics- Computer Science, Anadolu University, Eskisehir, Turkiye. FAU - Tahta, Tugba AU - Tahta T AD - Health Services Vocational School, Ankara Medipol University, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260306 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Retrospective Studies MH - Predictive Learning Models MH - *Infant, Small for Gestational Age MH - Adult MH - Infant, Newborn MH - Boosting Machine Learning Algorithms MH - Prediction Algorithms MH - Classification Algorithms MH - Parity MH - Logistic Models MH - *Machine Learning MH - Random Forest MH - Pregnancy Trimester, First PMC - PMC13020163 OTO - NOTNLM OT - Artificial intelligence OT - High-risk pregnancy OT - Machine learning OT - Obstetrics OT - Prediction OT - Small for gestational age COIS- Declarations. Ethics approval and consent to participate: This investigation was conducted in accordance with the Declaration of Helsinki and received ethical approval from the Ankara Medipol University Ethical Committee (Approval No. 08.01.2024/8). Due to the study's retrospective nature, patient consent was not required, and data were de-identified prior to analysis. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/06 09:07 MHDA- 2026/06/27 12:38 PMCR- 2026/03/06 CRDT- 2026/03/05 23:35 PHST- 2025/07/26 00:00 [received] PHST- 2026/03/02 00:00 [accepted] PHST- 2026/06/27 12:38 [medline] PHST- 2026/03/06 09:07 [pubmed] PHST- 2026/03/05 23:35 [entrez] PHST- 2026/03/06 00:00 [pmc-release] AID - 10.1186/s12884-026-08906-8 [pii] AID - 8906 [pii] AID - 10.1186/s12884-026-08906-8 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Mar 6;26(1):333. doi: 10.1186/s12884-026-08906-8. PMID- 41785991 OWN - NLM STAT- MEDLINE DCOM- 20260726 LR - 20260824 IS - 1885-5857 (Electronic) IS - 1885-5857 (Linking) VI - 79 IP - 8 DP - 2026 Aug TI - Validation of a VO(2)max Z-score model for fitness assessment in a healthy Spanish pediatric population. PG - 680-690 LID - S1885-5857(26)00037-X [pii] LID - 10.1016/j.rec.2026.02.006 [doi] AB - INTRODUCTION AND OBJECTIVES: Maximal oxygen uptake is the gold standard for assessing aerobic capacity in children and adolescents. Its interpretation requires robust reference models. A pediatric Z-score model has recently been developed, but external validation in independent cohorts is essential to confirm its applicability. METHODS: We conducted a multicenter validation study including a total of 1046 healthy participants (mean age, 12.0 +/- 2.6 years), composed of 2 cohorts: a prospective Spanish validation cohort (n = 175) and a previously published reference cohort (n = 871). The Z-score model was compared with historical weight- and height-based linear equations in terms of correlation, prediction error, and classification of impaired aerobic fitness. Subgroup analyses were performed by sex and body mass index. RESULTS: The Z-score model showed the strongest correlation between predicted and observed maximal oxygen uptake (R(2) = 0.70), outperforming weight-based (R(2) = 0.64) and height-based (R(2) = 0.66) equations. It yielded smaller prediction errors among body mass index groups and identified 14% of participants as having impaired aerobic fitness, compared with 20% and 23% using weight- and height-based reference models, respectively. The Z-score model showed improved consistency and reduced bias, particularly in overweight participants. CONCLUSIONS: The pediatric Z-score model demonstrated superior accuracy, consistency, and classification reliability compared with linear equations in a large, independent Spanish cohort. Its adoption may enhance the interpretation of pediatric cardiopulmonary exercise testing, support early identification of reduced aerobic fitness, and guide prevention strategies and tailored interventions. Registered on ClinicalTrials.gov (NCT04876209). CI - Copyright (c) 2026 Sociedad Espanola de Cardiologia. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Peiro-Molina, Esteban AU - Peiro-Molina E AD - Departamento de Cardiologia Pediatrica, Hospital Universitari i Politecnic La Fe, Valencia, Spain; Unidad de Medicina Regenerativa y Trasplante Cardiaco, Instituto de Investigacion Sanitaria La Fe (IISLAFE), Valencia, Spain. FAU - Gavotto, Arthur AU - Gavotto A AD - Department de Reanimation Neonatale et Pediatrique, CHU Montpellier, Montpellier, France; PhyMedExp, CNRS, INSERM, Universite de Montpellier, Montpellier, France. FAU - Robert, Julien AU - Robert J AD - Departement d'Epidemiologie, Sante Publique et Biostatistiques, CHU de Nimes, Nimes, France. FAU - Andrianoely, Mathieu AU - Andrianoely M AD - IHU Liryc, INSERM U1045, Universite de Bordeaux, Pessac, France; Just Coaching, Paris, France. FAU - Rezola, Erika AU - Rezola E AD - Instituto de Investigacion Sanitaria Biogipuzkoa, Area de Enfermedades Sistemicas, Grupo de Enfermedades Pediatricas, Hospital Universitario Donostia, Servicio de Pediatria, Donostia/San Sebastian, Spain. FAU - Manso, Begona AU - Manso B AD - Seccion de Cardiologia Pediatrica, Hospital Universitario Virgen del Rocio, Seville, Spain. FAU - Ferrer-Sargues, Francisco-Jose AU - Ferrer-Sargues FJ AD - Unidad de Medicina Regenerativa y Trasplante Cardiaco, Instituto de Investigacion Sanitaria La Fe (IISLAFE), Valencia, Spain; Departamento de Fisioterapia, Universidad Cardenal Herrera CEU, CEU Universities, Valencia, Spain. FAU - Carrasco-Moreno, Jose Ignacio AU - Carrasco-Moreno JI AD - Departamento de Cardiologia Pediatrica, Hospital Universitari i Politecnic La Fe, Valencia, Spain. FAU - Matecki, Stefan AU - Matecki S AD - PhyMedExp, CNRS, INSERM, Universite de Montpellier, Montpellier, France. FAU - Hager, Alfred AU - Hager A AD - Klinik fur Kinderkardiologie und Angeborene Herzfehler, Technische Universitat Munchen, Deutsches Herzzentrum Munchen, Munich, Germany. FAU - Gauthier, Naomi AU - Gauthier N AD - Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States. FAU - Yin, Suellen Moli AU - Yin SM AD - Department of Cardiology, Boston Children's Hospital, Harvard Medical School, Boston, United States. FAU - Guillaumont, Sophie AU - Guillaumont S AD - Service de Cardiologie Pediatrique, Centre de Competences M3C, CHU Montpellier, Montpellier, France; Service d'Explorations et Rehabilitation Cardiaque Pediatrique, Intitut Saint-Pierre, Palavas-Les-Flots, France. FAU - Mura, Thibault AU - Mura T AD - Departement d'Epidemiologie, Sante Publique et Biostatistiques, CHU de Nimes, Nimes, France. FAU - Borreguero, Jose Miguel Blanco AU - Borreguero JMB AD - Servicio de Pediatria, Hospital Universitario Virgen de Valme, Seville, Spain. FAU - Amedro, Pascal AU - Amedro P AD - IHU Liryc, INSERM U1045, Universite de Bordeaux, Pessac, France; Heart and Lung Center, Children's National Hospital, The George Washington University School of Medicine & Health Sciences, Washington DC, United States; Service de Cardiologie Pediatrique et Congenitale, Centre de Reference National M3C, CHU de Bordeaux, Bordeaux, France. Electronic address: pascal.amedro@gmail.com. CN - QUALIREHAB study group LA - eng LA - spa SI - ClinicalTrials.gov/NCT04876209 PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20260303 PL - Spain TA - Rev Esp Cardiol (Engl Ed) JT - Revista espanola de cardiologia (English ed.) JID - 101587954 SB - IM MH - Humans MH - Child MH - *Oxygen Consumption/physiology MH - Female MH - Spain/epidemiology MH - Male MH - Prospective Studies MH - Exercise Test/methods MH - Adolescent MH - *Physical Fitness/physiology MH - Reference Values MH - Body Mass Index MH - Reproducibility of Results MH - *Cardiorespiratory Fitness/physiology OTO - NOTNLM OT - Condicion fisica OT - Consumo de oxigeno OT - Exercise test OT - Oxygen consumption OT - Pediatrics OT - Pediatria OT - Physical fitness OT - Prueba de esfuerzo cardiopulmonar OT - Puntuacion Z OT - Reference values OT - Valores de referencia OT - Z-scores EDAT- 2026/03/06 08:57 MHDA- 2026/07/27 00:34 CRDT- 2026/03/05 19:12 PHST- 2025/11/04 00:00 [received] PHST- 2026/02/05 00:00 [accepted] PHST- 2026/07/27 00:34 [medline] PHST- 2026/03/06 08:57 [pubmed] PHST- 2026/03/05 19:12 [entrez] AID - S1885-5857(26)00037-X [pii] AID - 10.1016/j.rec.2026.02.006 [doi] PST - ppublish SO - Rev Esp Cardiol (Engl Ed). 2026 Aug;79(8):680-690. doi: 10.1016/j.rec.2026.02.006. Epub 2026 Mar 3. PMID- 41785233 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 3 DP - 2026 TI - Applying machine learning to predict stunting in children under 5 years old based on water, sanitation and hygiene behaviors and infrastructure. PG - e0343796 LID - 10.1371/journal.pone.0343796 [doi] LID - e0343796 AB - OBJECTIVE: Child stunting continues to pose a substantial global health challenge, requiring multifaceted strategies that combine conventional epidemiological approaches with advanced analytic methods. The aim of this study was to determine the most effective machine learning model for predicting stunting based on water, sanitation, and hygiene behaviors and infrastructure, with the goal of identifying high-risk children who would benefit most from targeted interventions. METHODS: This study was a secondary analysis of data from a matched cohort study assessing the effectiveness of combined on-premise piped water and improved sanitation for improved health outcomes in rural Odisha, India. Data for the parent study were collected from 2,398 households with a child under five years of age across 90 villages, and complete data were available for 1,196 children. Feature engineering techniques were employed to identify the most relevant predictors and utilized structural equation modeling, forward selection, backward elimination, and least absolute shrinkage and selection operator techniques. Five machine learning algorithms commonly used for binary classification tasks were compared: logistic regression, classification tree, support vector machine, neural network, and extreme gradient boosting. RESULTS: Among 1,196 children analyzed, the extreme gradient boosting model with forward selection feature engineering best predicted stunting based on water, sanitation, and hygiene (WaSH) factors. It correctly identified 81% of stunted children and 92% of non-stunted children, with an overall accuracy of 88%. The model's area under the receiver operating characteristic curve (AUROC) was 0.959 (95% CI: 0.949-0.968), indicating that WaSH factors strongly predict child stunting when analyzed using this advanced machine learning technique. Four WaSH factors were identified as having the strongest power to predict stunting in our sample: improved sanitation coverage, presence of a handwashing station, piped water coverage, and availability of preferred drinking water source. CONCLUSIONS: The results demonstrate the efficacy of machine learning algorithms, especially extreme gradient boosting to potentially inform targeted WaSH interventions for reducing childhood stunting in resource-limited settings. However, these findings require external validation in other populations, and the complete-case analysis approach (excluding 35% of children with missing data) may limit generalizability to settings with less systematic data collection. CI - Copyright: (c) 2026 Sinharoy et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Sinharoy, Sanaya AU - Sinharoy S AUID- ORCID: 0009-0005-4754-0818 AD - Independent Researcher, Doylestown, Pennsylvania, United States of America. FAU - Reese, Heather AU - Reese H AD - Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America. FAU - Clasen, Thomas AU - Clasen T AUID- ORCID: 0000-0003-4062-5788 AD - Gangarosa Department of Environmental Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America. FAU - Sinharoy, Sheela S AU - Sinharoy SS AUID- ORCID: 0000-0003-3077-3824 AD - Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, United States of America. LA - eng PT - Journal Article DEP - 20260305 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Sanitation MH - *Hygiene MH - *Machine Learning MH - *Growth Disorders/epidemiology/diagnosis/etiology MH - Child, Preschool MH - Boosting Machine Learning Algorithms MH - Male MH - India/epidemiology MH - Water Supply MH - Female MH - Classification Algorithms MH - Predictive Learning Models MH - Infant MH - Prediction Algorithms MH - Logistic Models PMC - PMC12962480 COIS- The authors have declared that no competing interests exist. EDAT- 2026/03/06 08:59 MHDA- 2026/03/08 06:38 PMCR- 2026/03/05 CRDT- 2026/03/05 13:36 PHST- 2024/09/02 00:00 [received] PHST- 2026/02/11 00:00 [accepted] PHST- 2026/03/08 06:38 [medline] PHST- 2026/03/06 08:59 [pubmed] PHST- 2026/03/05 13:36 [entrez] PHST- 2026/03/05 00:00 [pmc-release] AID - PONE-D-24-38002 [pii] AID - 10.1371/journal.pone.0343796 [doi] PST - epublish SO - PLoS One. 2026 Mar 5;21(3):e0343796. doi: 10.1371/journal.pone.0343796. eCollection 2026. PMID- 41784603 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260921 IS - 1097-6752 (Electronic) IS - 0889-5406 (Print) IS - 0889-5406 (Linking) VI - 169 IP - 6 DP - 2026 Jun TI - Craniofacial growth percentile curves: A clinical tool from the Craniofacial Growth Consortium Study. PG - 720-734 LID - S0889-5406(26)00024-7 [pii] LID - 10.1016/j.ajodo.2025.11.026 [doi] AB - INTRODUCTION: This study aimed to develop new cephalometric standards incorporating samples from across North America, focusing on creating sex-specific percentile growth curves for craniofacial cephalometric measures using the extensive longitudinal data from the Craniofacial Growth Consortium Study. METHODS: This study comprised 2,100 subjects (1,056 males and 1,044 females) with 17,290 lateral cephalometric radiographs, spanning ages of 2.5-31.3 years. Twenty-four linear cephalometric measurements were calculated, including traits from the basicranium, maxilla, and mandible. For each measurement, multilevel nonlinear growth models were used to estimate growth milestones by sex, percentile growth curves were created, and a web-interface tool was developed to facilitate the practical application of these growth curves. RESULTS: Growth milestones, including age at peak growth velocity and peak growth velocity, were estimated for each sex using double logistic growth models. The timing of peak growth velocity varies across different regions of the craniofacial complex. Craniofacial growth percentile curves were created and cross-validated. A web interface tool was created to allow users to retrieve individual-specific percentile scores. CONCLUSIONS: The developed percentile growth curves and web-based tool offer a robust framework for clinicians to assess individual growth patterns, identify deviations from normative growth, and estimate future growth potential, supporting more personalized treatment planning and timing. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Oh, Heesoo AU - Oh H AD - Department of Orthodontics, University of the Pacific, Arthur A Dugoni School of Dentistry, San Francisco, Calif. FAU - Middleton, Kevin M AU - Middleton KM AD - Division of Biological Sciences, University of Missouri, Columbia, Mo. FAU - Valiathan, Manish AU - Valiathan M AD - Department of Orthodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio. FAU - Duren, Dana L AU - Duren DL AD - Department of Orthopedic Surgery, University of Missouri School of Medicine, Columbia, Mo; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Mo. FAU - McNulty, Kieran P AU - McNulty KP AD - Department of Ecology, Evolution, and Behavior, University of Minnesota, Minneapolis, Minn. FAU - McNamara, James A Jr AU - McNamara JA Jr AD - Department of Orthodontics and Pediatric Dentistry, School of Dentistry, The University of Michigan, Ann Arbor, Mich; Department of Cell and Developmental Biology, School of Medicine, The University of Michigan, Ann Arbor, Mich; Center for Human Growth and Development, The University of Michigan, Ann Arbor, Mich. FAU - Hans, Mark AU - Hans M AD - Department of Orthodontics, School of Dental Medicine, Case Western Reserve University, Cleveland, Ohio. FAU - Sherwood, Richard J AU - Sherwood RJ AD - Department of Orthopedic Surgery, University of Missouri School of Medicine, Columbia, Mo; Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Mo. Electronic address: sherwoodrj@health.missouri.edu. LA - eng GR - R01 DE024732/DE/NIDCR NIH HHS/United States PT - Journal Article DEP - 20260304 PL - United States TA - Am J Orthod Dentofacial Orthop JT - American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics JID - 8610224 SB - IM MH - Humans MH - *Cephalometry/methods MH - Male MH - Female MH - Child, Preschool MH - Child MH - Adolescent MH - *Growth Charts MH - *Skull/growth & development MH - Longitudinal Studies MH - *Maxillofacial Development MH - Reference Values PMC - PMC13138386 MID - NIHMS2154680 COIS- All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest, and none were reported. EDAT- 2026/03/05 12:49 MHDA- 2026/05/27 00:30 PMCR- 2026/05/05 CRDT- 2026/03/05 10:45 PHST- 2024/09/01 00:00 [received] PHST- 2025/11/01 00:00 [revised] PHST- 2025/11/01 00:00 [accepted] PHST- 2026/05/27 00:30 [medline] PHST- 2026/03/05 12:49 [pubmed] PHST- 2026/03/05 10:45 [entrez] PHST- 2026/05/05 00:00 [pmc-release] AID - S0889-5406(26)00024-7 [pii] AID - 10.1016/j.ajodo.2025.11.026 [doi] PST - ppublish SO - Am J Orthod Dentofacial Orthop. 2026 Jun;169(6):720-734. doi: 10.1016/j.ajodo.2025.11.026. Epub 2026 Mar 4. PMID- 41784418 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1473-5687 (Electronic) IS - 0954-691X (Linking) VI - 38 IP - 6 DP - 2026 Jun 1 TI - SAFE vs. FIB-4: diagnostic accuracy for clinically significant fibrosis in U.S. adults with cardiometabolic risk factors - a NHANES 2017-2020 analysis. PG - 738-746 LID - 10.1097/MEG.0000000000003161 [doi] AB - BACKGROUND: Steatotic liver disease (SLD), largely driven by cardiometabolic dysfunction, affects nearly one-third of the global population and may progress to advanced fibrosis. Although liver biopsy remains the gold standard for fibrosis assessment, noninvasive tools such as the Fibrosis-4 (FIB-4) and the recently developed steatosis-associated fibrosis estimator (SAFE) score are used risk stratification. We compared the diagnostic accuracy of FIB-4 and SAFE for detecting clinically significant fibrosis in adults with cardiometabolic risk factors. METHODS: We conducted a cross-sectional analysis of 2196 adults aged 18-80 years from the National Health and Nutrition Examination Survey (2017-2020) with valid liver stiffness measurements (LSM) by FibroScan. Individuals with known chronic liver disease, excessive alcohol use, or missing data were excluded. Clinically significant fibrosis was defined as LSM >/= 8.0 kPa. Diagnostic performance was evaluated using sensitivity, specificity, predictive values, and area under the receiver operating characteristic curve (AUC). RESULTS: SAFE demonstrated superior discrimination compared with FIB-4 (AUC 0.719 vs. 0.578; P < 0.001). As a rule-out test, SAFE showed higher sensitivity (78% vs. 41%) and negative predictive value (95% vs. 91%). FIB-4 missed 58.6% of patients with significant fibrosis, whereas SAFE missed 22%. SAFE consistently outperformed FIB-4 across age, sex, MASLD status, and glycemic control subgroups. CONCLUSION: These findings support the use of SAFE over FIB-4 as a noninvasive screening tool for significant fibrosis in patients with cardiometabolic risk factors. CI - Copyright (c) 2026 Wolters Kluwer Health, Inc. All rights reserved. FAU - Aydin, Adem AU - Aydin A AD - Department of Internal Medicine, Saint Mary's Hospital, Waterbury, Connecticut. FAU - Aydin, Yucel AU - Aydin Y AD - Division of Gastroenterology, Tulane University, New Orleans, Louisiana, USA. FAU - Borz-Baba, Carolina I AU - Borz-Baba CI AD - Department of Internal Medicine, Saint Mary's Hospital, Waterbury, Connecticut. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260428 PL - England TA - Eur J Gastroenterol Hepatol JT - European journal of gastroenterology & hepatology JID - 9000874 SB - IM MH - Humans MH - Adult MH - Female MH - Middle Aged MH - Male MH - *Liver Cirrhosis/diagnosis/etiology/blood/epidemiology MH - Cross-Sectional Studies MH - Nutrition Surveys MH - Aged MH - Cardiometabolic Risk Factors MH - United States/epidemiology MH - Young Adult MH - Predictive Value of Tests MH - Adolescent MH - Aged, 80 and over MH - Risk Assessment/methods MH - Elasticity Imaging Techniques MH - *Fatty Liver/complications/diagnosis MH - Risk Factors OTO - NOTNLM OT - FIB-4 OT - NHANES OT - SAFE score OT - noninvasive fibrosis test OT - steatotic liver disease EDAT- 2026/03/05 12:47 MHDA- 2026/05/01 18:44 CRDT- 2026/03/05 09:22 PHST- 2025/06/11 00:00 [received] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/05/01 18:44 [medline] PHST- 2026/03/05 12:47 [pubmed] PHST- 2026/03/05 09:22 [entrez] AID - 00042737-990000000-00662 [pii] AID - 10.1097/MEG.0000000000003161 [doi] PST - ppublish SO - Eur J Gastroenterol Hepatol. 2026 Jun 1;38(6):738-746. doi: 10.1097/MEG.0000000000003161. Epub 2026 Apr 28. PMID- 41784346 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260917 IS - 1460-2229 (Electronic) IS - 0263-2136 (Linking) VI - 43 IP - 2 DP - 2026 Feb 7 TI - Early detection of low lean mass in adults using machine learning: a primary care-oriented approach. LID - cmag002 [pii] LID - 10.1093/fampra/cmag002 [doi] AB - BACKGROUND: Low lean mass (LLM) is a key determinant of morbidity and mortality, particularly in older adults. Although dual-energy X-ray absorptiometry (DXA) is the gold standard for assessment, its high cost and limited availability hinder widespread screening. OBJECTIVES: To develop and evaluate machine learning (ML) models for predicting LLM using easily obtainable demographic and clinical features, based on a cross-sectional analysis of NHANES 2011-2014, focusing on young and middle-aged adults (18-59 years). METHODS: LLM was defined using DXA-derived appendicular skeletal muscle mass adjusted for BMI (ASM/BMI) based on the Foundation for the National Institutes of Health (FNIH) criteria. Six ML algorithms-Logistic Regression, Decision Tree, Random Forest, LightGBM, XGBoost, and Support Vector Machine-were trained using age, gender, height, weight, and handgrip strength. RESULTS: Among 6045 participants, 7% had LLM. The XGBoost model achieved an AUC of 0.94 (95% CI: 0.92-0.96), an F1-score of 0.54, sensitivity of 46%, and specificity of 98%. Although XGBoost showed the highest numerical F1-score, bootstrap comparisons indicated no statistically significant differences in F1-score across models. In contrast, XGBoost demonstrated significantly higher discrimination than the Decision Tree model according to DeLong's test. All algorithms showed high specificity (>98%) and accuracy (>94%), with markedly variable sensitivity (35%-48%). CONCLUSIONS: Machine learning models using simple and low-cost predictors can estimate the probability of LLM with acceptable discrimination. The proposed model may assist primary care clinicians in risk stratification once externally validated. Further work is needed to establish operational thresholds and evaluate real-world clinical utility. CI - (c) The Author(s) 2026. Published by Oxford University Press. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Arlettaz, Maximiliano Ezequiel AU - Arlettaz ME AUID- ORCID: 0000-0002-7507-7059 AD - Universidad Nacional de Entre Rios-Concepcion del Uruguay P.C. 3260, Argentina. FAU - Staurini, Stefano AU - Staurini S AD - Centro de Investigaciones en Nutricion Humana (CenINH)-Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba P.C. 5000, Argentina. FAU - Ormaechea, Camila AU - Ormaechea C AD - Centro de Investigaciones en Nutricion Humana (CenINH)-Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba P.C. 5000, Argentina. FAU - Gonzalez, Maria Fernanda AU - Gonzalez MF AD - Universidad Nacional de Entre Rios-Concepcion del Uruguay P.C. 3260, Argentina. FAU - Aballay, Laura R AU - Aballay LR AD - Centro de Investigaciones en Nutricion Humana (CenINH)-Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Cordoba P.C. 5000, Argentina. LA - eng PT - Journal Article PL - England TA - Fam Pract JT - Family practice JID - 8500875 SB - IM MH - Humans MH - Female MH - Male MH - Middle Aged MH - Adult MH - Cross-Sectional Studies MH - Primary Health Care MH - Absorptiometry, Photon MH - *Machine Learning MH - Boosting Machine Learning Algorithms MH - Young Adult MH - Adolescent MH - Body Mass Index MH - Random Forest MH - Early Diagnosis MH - *Sarcopenia/diagnosis MH - Predictive Learning Models MH - Nutrition Surveys MH - Logistic Models MH - Classification Algorithms MH - Prediction Algorithms MH - Decision Trees OAB - Low lean mass (LLM) refers to having reduced muscle tissue, which can lead to serious health problems like weakness, fatigue, and a higher risk of chronic diseases. It is often difficult to detect early because the best tools, like DXA scans, are expensive and not widely available in regular health checkups. In this study, we used data from a large U.S. health survey to test whether machine learning-computer programs that can find patterns in data-can help identify people with LLM using simple information like age, height, weight, gender, and handgrip strength. We evaluated six different machine learning methods. One of them, called XGBoost, showed the most favorable overall balance between correctly identifying people with LLM and avoiding false positives, and had better discriminatory ability than a comparable tree-based model. At the same time, the model tended to underestimate the absolute level of risk, its sensitivity was modest, and the clinical benefit suggested by decision curve analysis was limited. These results suggest that, after further validation in real-world healthcare settings, such models could complement existing tools and help clinicians recognize low muscle mass earlier using only simple, routinely collected measurements. OABL- eng OTO - NOTNLM OT - artificial intelligence OT - body composition OT - lean mass OT - machine learning OT - sarcopenia COIS- Conflicts of interest: The authors declare no competing interests with respect to this publication. EDAT- 2026/03/05 12:49 MHDA- 2026/03/08 01:38 CRDT- 2026/03/05 08:43 PHST- 2026/03/08 01:38 [medline] PHST- 2026/03/05 12:49 [pubmed] PHST- 2026/03/05 08:43 [entrez] AID - 8507058 [pii] AID - 10.1093/fampra/cmag002 [doi] PST - ppublish SO - Fam Pract. 2026 Feb 7;43(2):cmag002. doi: 10.1093/fampra/cmag002. PMID- 41784093 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260812 IS - 2472-1727 (Electronic) VI - 118 IP - 3 DP - 2026 Mar TI - Prevalence and Risk Factors of Postpartum Depression in Southeastern Iranian Women. PG - e70033 LID - 10.1002/bdr2.70033 [doi] AB - BACKGROUND: Postpartum depression (PPD) significantly impacts maternal mental health and child well-being, necessitating a clear understanding of its prevalence and risk factors to inform effective interventions in Iran. METHODS: This cross-sectional study, conducted in Kerman, eastern Iran, from April to December 2023, recruited 876 women from multiple healthcare centers. Data were collected using the validated Persian Edinburgh Postnatal Depression Scale (EPDS, score > 12) with DSM-5 clinical confirmation, alongside a questionnaire assessing demographic characteristics, socioeconomic status, marital relationships, and support systems. Logistic regression analyses determined the point prevalence of PPD and identified significant risk and protective factors. RESULTS: The point prevalence of PPD was 29.1% (255/876, 95% CI: 26.2-32.2). Independent predictors of higher PPD odds included delivery outside a healthcare facility (AOR = 1.60, 95% CI: 1.25-2.21, p = 0.015), maternal history of depression (AOR = 2.20, 95% CI: 1.60-3.00, p < 0.001), infant abnormalities (AOR = 1.60, 95% CI: 1.10-2.40, p = 0.014), poor breastfeeding experience (AOR = 2.50, 95% CI: 1.30-4.70, p = 0.006), excessive infant crying (AOR = 1.70, 95% CI: 1.20-2.50, p = 0.003), husband's chronic illness (AOR = 1.32, 95% CI: 1.21-1.69, p = 0.043), and husband's history of depression (AOR = 1.43, 95% CI: 1.17-1.72, p = 0.045). Protective factors included husband's involvement in childcare (AOR = 0.61, 95% CI: 0.42-0.90, p = 0.017), adequate emotional support (AOR = 0.65, 95% CI: 0.45-0.95, p = 0.025), and satisfaction with the baby's gender (AOR = 0.71, 95% CI: 0.50-0.95, p = 0.023). CONCLUSION: The 29.1% point prevalence of PPD underscores the urgent need for enhanced screening, community-based support, and targeted interventions addressing modifiable factors like breastfeeding difficulties and partner support to improve maternal and child health outcomes in Iran. CI - (c) 2026 Wiley Periodicals LLC. FAU - Dehesh, Tania AU - Dehesh T AD - Department of Biostatistics and Epidemiology, School of Public Health, Kerman University of Medical Sciences, Kerman, Iran. FAU - Jafari, Samira AU - Jafari S AUID- ORCID: 0000-0003-2874-0417 AD - Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran. FAU - Dehesh, Paria AU - Dehesh P AD - Social Determinants of Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran. LA - eng PT - Journal Article PL - United States TA - Birth Defects Res JT - Birth defects research JID - 101701004 SB - IM MH - Humans MH - Female MH - Iran/epidemiology MH - *Depression, Postpartum/epidemiology/psychology MH - Risk Factors MH - Prevalence MH - Adult MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Breast Feeding MH - Logistic Models MH - Pregnancy MH - Young Adult OTO - NOTNLM OT - Iran OT - postpartum depression OT - prevalence OT - risk factors EDAT- 2026/03/05 12:48 MHDA- 2026/03/06 08:57 CRDT- 2026/03/05 06:42 PHST- 2026/02/02 00:00 [revised] PHST- 2025/03/29 00:00 [received] PHST- 2026/02/08 00:00 [accepted] PHST- 2026/03/06 08:57 [medline] PHST- 2026/03/05 12:48 [pubmed] PHST- 2026/03/05 06:42 [entrez] AID - 10.1002/bdr2.70033 [doi] PST - ppublish SO - Birth Defects Res. 2026 Mar;118(3):e70033. doi: 10.1002/bdr2.70033. PMID- 41783905 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260305 LR - 20260920 IS - 2353-5571 (Electronic) IS - 2353-4184 (Print) IS - 2353-5571 (Linking) VI - 14 IP - 1 DP - 2025 TI - Impact of personality traits and motivation on adolescent sports participation. PG - 78-91 LID - 10.5114/hpr/212560 [doi] AB - BACKGROUND: Participation in physical-sporting activities is associated with positive physical, emotional, and social development during adolescence, a critical period characterized by significant biological, cognitive, and social changes. These developmental processes interact dynamically with individual differences in psychological traits and motivational factors, which strongly affect adolescents' sustained engagement and overall health outcomes through sport. PARTICIPANTS AND PROCEDURE: A sample of adolescents was assessed using validated questionnaires measuring intrinsic and extrinsic motivation, personality traits, and levels of physical activity. Statistical analyses were conducted to examine associations between these variables and to identify gender differences. RESULTS: Intrinsic motivation was found to be strongly associated with sports engagement, showing a higher correlation than extrinsic motivation. Personality traits such as extraversion were positively associated with higher physical activity levels; gender differences emerged in neuroticism and conscientiousness, with females scoring higher in these traits. Adolescents exhibiting high intrinsic motivation showed lower neuroticism and greater openness to experience, outlining a characteristic psychosocial profile linked to sustained sports participation. CONCLUSIONS: These findings highlight the importance of integrating both motivation and personality considerations when developing interventions aimed at promoting active and healthy lifestyles in adolescence. Understanding these psychological factors can facilitate the creation of tailored strategies by educators, families, and sports professionals to enhance youth engagement and well-being. CI - Copyright (c) Institute of Psychology, University of Gdansk. FAU - Diaz-Rodriguez, Carlos AU - Diaz-Rodriguez C AUID- ORCID: 0000-0002-5110-2352 AD - University of Oviedo, Oviedo, Spain. FAU - Martinez-Lopez, Fernando AU - Martinez-Lopez F AUID- ORCID: 0000-0001-6490-0997 AD - Rey Juan Carlos University (URJC), Madrid, Spain. FAU - Catalina, Alvaro Dietta AU - Catalina AD AUID- ORCID: 0009-0001-6343-0468 AD - Comillas Pontifical University, Madrid, Spain. LA - eng PT - Journal Article DEP - 20251216 PL - Poland TA - Health Psychol Rep JT - Health psychology report JID - 101677269 PMC - PMC12955768 OTO - NOTNLM OT - adolescence OT - gender OT - intrinsic motivation OT - personality OT - physical-sporting activity EDAT- 2026/03/05 07:09 MHDA- 2026/03/05 07:10 PMCR- 2025/12/16 CRDT- 2026/03/05 04:58 PHST- 2025/08/18 00:00 [received] PHST- 2025/09/19 00:00 [revised] PHST- 2025/10/14 00:00 [accepted] PHST- 2026/03/05 07:10 [medline] PHST- 2026/03/05 07:09 [pubmed] PHST- 2026/03/05 04:58 [entrez] PHST- 2025/12/16 00:00 [pmc-release] AID - 212560 [pii] AID - 10.5114/hpr/212560 [doi] PST - epublish SO - Health Psychol Rep. 2025 Dec 16;14(1):78-91. doi: 10.5114/hpr/212560. eCollection 2025. PMID- 41783834 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260305 LR - 20260813 IS - 2773-0654 (Electronic) IS - 2773-0654 (Linking) VI - 5 IP - 2 DP - 2026 Apr TI - Leveraging Youth Sports to Deliver a Physical Activity Intervention to Mothers: Feasibility, Acceptability, and Preliminary Efficacy of a Single-Arm Open Pilot Trial. PG - 100465 LID - 10.1016/j.focus.2025.100465 [doi] LID - 100465 AB - INTRODUCTION: Mothers have increased risk for insufficient physical activity and face various barriers to engaging in physical activity. Youth sports have been examined as a setting for health-promotion interventions for children but not for parents. The authors conducted a 6-week single-arm open pilot trial of a physical activity intervention delivered to mothers in Rhode Island, U.S. during children's sports practices. METHODS: The authors partnered with a youth football organization to deliver the intervention, which consisted of group physical activity sessions during practice. Feasibility was determined on the basis of whether enrollment (i.e., >/=8 participants per week), retention (i.e., >/=80% of participants through 6 weeks), and assessment (i.e., obtaining usable physical activity data from >/=80% of participants) targets were met. Acceptability was determined on the basis of participant responses to a consumer satisfaction questionnaire (with the intervention deemed satisfactory if >/=80% of participants were satisfied with the intervention) and engagement (i.e., intervention session attendance). Preliminary efficacy was determined on the basis of whether participants experienced increases in moderate-to-vigorous physical activity, assessed through 7-day physical activity recall, or physical activity self-efficacy, assessed through the self-efficacy for physical activity measure, at 3 and 6 weeks relative to baseline. The authors descriptively analyzed postintervention feasibility, acceptability, sociodemographic characteristics, and preliminary efficacy outcomes. To explore preliminary efficacy estimates, the authors ran a series of unadjusted paired t-tests to compare baseline moderate-to-vigorous physical activity and self-efficacy with moderate-to-vigorous physical activity and self-efficacy at 3 and 6 weeks. RESULTS: The authors met recruitment (n=26) and retention (85%) targets but only collected follow-up data from 12 participants (aged 30-62 years). Twelve of 18 planned intervention sessions were offered owing to practice cancellations; participant attendance ranged from 0 to 12 sessions (mean=3.52, SD=4.07). All participants (100%) were satisfied with the intervention, and significant increases in moderate-to-vigorous physical activity and physical activity self-efficacy were observed. Specifically, an increase in moderate-to-vigorous physical activity from baseline to 3 weeks of 114.5 minutes was observed (Cohen's d=0.75), whereas self-efficacy scores increased by 0.98 (Cohen's d=0.97). Self-efficacy scores were increased by 1.07 (Cohen's d=0.91) at 6 weeks. CONCLUSIONS: This study demonstrated the feasibility of delivering a physical activity intervention to mothers during youth sports practices, although the authors did not reach the assessment target. Participants were satisfied with the intervention, and increases in physical activity outcomes were observed. However, studies examining strategies to increase engagement and maximize benefits, particularly among insufficiently active mothers, would be beneficial. Nonetheless, this is the first study to demonstrate the potential of youth sports practices as a setting for delivering health promotion interventions to parents. CI - (c) 2025 The Authors. FAU - von Ash, Tayla AU - von Ash T AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, Rhode Island. FAU - O'Hagan, Belinda AU - O'Hagan B AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, Rhode Island. FAU - Gupta-Louis, Sugandha K AU - Gupta-Louis SK AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, Rhode Island. FAU - Dunsiger, Shira AU - Dunsiger S AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, Rhode Island. FAU - Toure, Fadilatou AU - Toure F AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, Rhode Island. FAU - Bohlen, Lauren Connell AU - Bohlen LC AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, Rhode Island. FAU - Benitez, Tanya J AU - Benitez TJ AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, Rhode Island. FAU - Murphy, Cara M AU - Murphy CM AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, Rhode Island. FAU - Pindus, Dominika M AU - Pindus DM AD - Department of Kinesiology, University of Massachusetts Amherst, Amherst, Massachusetts. FAU - Brown, Candace S AU - Brown CS AD - Department of Epidemiology and Community Health, University of North Carolina at Charlotte, Charlotte, North Carolina. FAU - Marcus, Bess H AU - Marcus BH AD - Department of Behavioral and Social Sciences, Brown University School of Public Health, Providence, Rhode Island. LA - eng PT - Journal Article DEP - 20251105 PL - United States TA - AJPM Focus JT - AJPM focus JID - 9918487585606676 PMC - PMC12955661 OTO - NOTNLM OT - Physical activity OT - community-based OT - mothers OT - pilot OT - youth sports EDAT- 2026/03/05 07:09 MHDA- 2026/03/05 07:10 PMCR- 2025/11/05 CRDT- 2026/03/05 04:58 PHST- 2026/03/05 07:10 [medline] PHST- 2026/03/05 07:09 [pubmed] PHST- 2026/03/05 04:58 [entrez] PHST- 2025/11/05 00:00 [pmc-release] AID - S2773-0654(25)00153-1 [pii] AID - 100465 [pii] AID - 10.1016/j.focus.2025.100465 [doi] PST - epublish SO - AJPM Focus. 2025 Nov 5;5(2):100465. doi: 10.1016/j.focus.2025.100465. eCollection 2026 Apr. PMID- 41783825 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260926 IS - 1661-8564 (Electronic) IS - 1661-8556 (Print) IS - 1661-8556 (Linking) VI - 71 DP - 2026 TI - The First Swiss National Nutrition Survey in Children and Adolescents, menuCH-Kids: Study Design, Participants, and Data Quality. PG - 1609314 LID - 10.3389/ijph.2026.1609314 [doi] LID - 1609314 AB - OBJECTIVES: menuCH-Kids was launched to generate the first Swiss nationwide children's dietary data, assess food contaminant exposure, and inform nutrition policies. This paper describes the methods, data quality, and participants characteristics. METHODS: In 2023-2024, a cross-sectional population-based survey in six Swiss centres collected dietary data via two non-consecutive 24-hour recalls/records and a Food Propensity Questionnaire; lifestyle, health, eating behaviours and sociodemographic information via online questionnaires; anthropometrics, urine, and voluntary blood samples by trained professionals with standardized procedures in 6-17-year-olds. Area-based socioeconomic position (Swiss-SEP) was linked to home addresses. Statistical weights corrected for unequal selection probabilities and non-response. Factors associated with participation were explored using logistic regressions. RESULTS: 1,852 participants attended the visit (participation rate = 11.9%). Data quality was high (<6% missing values, 15.1% dietary under-reporters, and 98% of biosamples processed on time). Non-participants were older, male, non-Swiss, from lower socioeconomic neighbourhoods, and smaller household. Adding socioeconomic position improved participation prediction models. CONCLUSION: menuCH-Kids provides high-quality dietary and health data on Swiss youth. Low participation highlights the need for a weighting strategy including socioeconomic position to compensate biases. CI - Copyright (c) 2026 Vincentini, Riou, Hausermann, Schwitzguebel, Estoppey Younes, Catalano, Brombach, Chaouch, Chatelan, Dratva, Isler, Muller, Rezzi, Righini-Grunder, Rohrmann, Saner, Simonetti, Uhlmann, Vanoni, Zuberbuehler, Siegfried-Troxler, Suggs, van der Horst and Bochud. FAU - Vincentini, Julia AU - Vincentini J AD - Department of Epidemiology and Health Systems, Unisante, University Center for Primary Care and Public Health and University of Lausanne, Lausanne, Switzerland. FAU - Riou, Julien AU - Riou J AD - Department of Epidemiology and Health Systems, Unisante, University Center for Primary Care and Public Health and University of Lausanne, Lausanne, Switzerland. FAU - Hausermann, Tanja AU - Hausermann T AD - School of Health Professions, Bern University of Applied Sciences, Bern, Switzerland. FAU - Schwitzguebel, Joelle AU - Schwitzguebel J AD - Department of Epidemiology and Health Systems, Unisante, University Center for Primary Care and Public Health and University of Lausanne, Lausanne, Switzerland. FAU - Estoppey Younes, Sandrine AU - Estoppey Younes S AD - Department of Epidemiology and Health Systems, Unisante, University Center for Primary Care and Public Health and University of Lausanne, Lausanne, Switzerland. FAU - Catalano, Loan AU - Catalano L AD - School of Health Professions, Bern University of Applied Sciences, Bern, Switzerland. FAU - Brombach, Christine AU - Brombach C AD - Institute of Food technology, Zurich University of Applied Sciences, Wadenswil, Switzerland. FAU - Chaouch, Aziz AU - Chaouch A AD - Department of Epidemiology and Health Systems, Unisante, University Center for Primary Care and Public Health and University of Lausanne, Lausanne, Switzerland. FAU - Chatelan, Angeline AU - Chatelan A AD - Department of Nutrition and Dietetics, Geneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Carouge-Geneva, Switzerland. FAU - Dratva, Julia AU - Dratva J AD - Institute of Public Health, Zurich University of Applied Sciences, Winterthur, Switzerland. FAU - Isler, Franziska AU - Isler F AD - YouGov Schweiz, Zurich, Switzerland. FAU - Muller, Pascal AU - Muller P AD - Adolescent Medicine and Paediatric Psychosomatics, Children's Hospital of Eastern Switzerland, St. Gallen, Switzerland. FAU - Rezzi, Serge AU - Rezzi S AD - Swiss Nutrition and Health Foundation, Lausanne, Switzerland. FAU - Righini-Grunder, Franziska AU - Righini-Grunder F AD - Children's Hospital of Central Switzerland, Lucerne, Switzerland. FAU - Rohrmann, Sabine AU - Rohrmann S AD - Epidemiology, Biostatistics and Prevention Institute (EBPI), University of Zurich, Zurich, Switzerland. FAU - Saner, Christoph AU - Saner C AD - Department of Pediatrics, Inselspital - Bern University Hospital and University of Bern, Bern, Switzerland. FAU - Simonetti, Giacomo D AU - Simonetti GD AD - Paediatric Institute of Southern Switzerland, Regional Hospital of Bellinzona - EOC and University of Lugano, Bellinzona, Switzerland. FAU - Uhlmann, Katja AU - Uhlmann K AD - School of Health Professions, Bern University of Applied Sciences, Bern, Switzerland. FAU - Vanoni, Federica AU - Vanoni F AD - Paediatric Institute of Southern Switzerland, Regional Hospital of Bellinzona - EOC and University of Lugano, Bellinzona, Switzerland. FAU - Zuberbuehler, Christine Anne AU - Zuberbuehler CA AD - Division of Food and Nutrition, Federal Food Safety and Veterinary Office, Bern, Switzerland. FAU - Siegfried-Troxler, Aline AU - Siegfried-Troxler A AD - Division of Food and Nutrition, Federal Food Safety and Veterinary Office, Bern, Switzerland. FAU - Suggs, Suzanne AU - Suggs S AD - Faculty of Communication, Culture and Society, University of Lugano, Lugano, Switzerland. FAU - van der Horst, Klazine AU - van der Horst K AD - School of Health Professions, Bern University of Applied Sciences, Bern, Switzerland. FAU - Bochud, Murielle AU - Bochud M AD - Department of Epidemiology and Health Systems, Unisante, University Center for Primary Care and Public Health and University of Lausanne, Lausanne, Switzerland. LA - eng PT - Journal Article DEP - 20260217 PL - Switzerland TA - Int J Public Health JT - International journal of public health JID - 101304551 SB - IM MH - Humans MH - Male MH - Switzerland MH - Adolescent MH - Child MH - Cross-Sectional Studies MH - *Nutrition Surveys/methods MH - Female MH - *Data Accuracy MH - Socioeconomic Factors MH - Research Design MH - Life Style MH - Diet PMC - PMC12953171 OTO - NOTNLM OT - 24-hours dietary recalls OT - Switzerland OT - children and adolescents OT - nutrition survey OT - participation bias COIS- Author FI was employed by the company YouGov Schweiz. The remaining authors declare that they do not have any conflicts of interest. EDAT- 2026/03/05 07:09 MHDA- 2026/03/07 01:37 PMCR- 2026/02/17 CRDT- 2026/03/05 04:58 PHST- 2025/11/12 00:00 [received] PHST- 2025/12/31 00:00 [revised] PHST- 2026/01/21 00:00 [accepted] PHST- 2026/03/07 01:37 [medline] PHST- 2026/03/05 07:09 [pubmed] PHST- 2026/03/05 04:58 [entrez] PHST- 2026/02/17 00:00 [pmc-release] AID - 1609314 [pii] AID - 10.3389/ijph.2026.1609314 [doi] PST - epublish SO - Int J Public Health. 2026 Feb 17;71:1609314. doi: 10.3389/ijph.2026.1609314. eCollection 2026. PMID- 41783820 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260305 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - Grip and pinch strengths and its association with cardiometabolic risk in children and adolescents aged 6 to 17 years. PG - 1763759 LID - 10.3389/fnut.2026.1763759 [doi] LID - 1763759 AB - BACKGROUND: To describe the absolute and body composition-normalized relative grip and pinch strength status in children and adolescents, to analyze the associations between strength indices and cardiometabolic risk. METHODS: The baseline survey from 2022 to 2023 conducted by the Beijing Children and Adolescents Health Cohort. Children aged 6-17 years old in Beijing were involved (N = 3,252). Health examination included height, body composition, grip and pinch strengths, blood pressure, triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), etc. Clustered metabolic syndrome composite score (MetScore) was calculated. Grip and pinch strengths were normalized by muscle mass percentage (MMP), body weight, BMI and muscle mass as strength indices, recorded as Grip-to-MMP ratio, etc. The receiver operating characteristic (ROC) curves were generated for age- and sex-specific muscle strength indices predicting abnormal cardiometabolic parameters. RESULTS: 3,252 children and adolescents were included. Both grip and pinch strength increased with age, with boys stronger than girls. Absolute grip strength and Grip-to-MMP ratio were positively associated with the risks of developing low HDL-c, high LDL-c, HBP, and a high MetScore. In contrast, the Grip-to-WT ratio was negatively associated with the risks of high TG, low HDL-c, high LDL-c, HBP, and a high MetScore, while being positively associated with the risk of IFG. Similar patterns were observed for pinch strength and its normalized indices. The Pinch-to-WT ratio and Pinch-to-BMI ratio showed protective, inverse associations with the risks of high TG, low HDL -c, high LDL-c, HBP, and a high MetScore. ROC analysis identified the Grip-to-WT ratio as the strongest predictor of cardiometabolic risk among all indices evaluated. CONCLUSION: Grip and pinch strengths seemed associated with cardiometabolic risk in children. The Grip/Pinch-to-WT ratio was the best predictor of cardiometabolic risk than all the other strength indices. Testing grip strength might help prevent cardiovascular disease early. CI - Copyright (c) 2026 Chen, Huang, Wu, Liao, Li, Liu, Zong and Chen. FAU - Chen, Yiren AU - Chen Y AD - Department of Epidemiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Huang, Yiying AU - Huang Y AD - Department of Epidemiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Wu, Lijun AU - Wu L AD - Department of Epidemiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Liao, Zijun AU - Liao Z AD - Department of Epidemiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Li, Shaoli AU - Li S AD - Department of Epidemiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Liu, Junting AU - Liu J AD - Department of Epidemiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Zong, Xinnan AU - Zong X AD - Department of Epidemiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. FAU - Chen, Fangfang AU - Chen F AD - Department of Epidemiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. LA - eng PT - Journal Article DEP - 20260217 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12953518 OTO - NOTNLM OT - adolescents OT - cardiometabolic risk OT - children OT - grip strength OT - pinch strength COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/05 07:09 MHDA- 2026/03/05 07:10 PMCR- 2026/02/17 CRDT- 2026/03/05 04:58 PHST- 2025/12/09 00:00 [received] PHST- 2026/01/19 00:00 [revised] PHST- 2026/02/03 00:00 [accepted] PHST- 2026/03/05 07:10 [medline] PHST- 2026/03/05 07:09 [pubmed] PHST- 2026/03/05 04:58 [entrez] PHST- 2026/02/17 00:00 [pmc-release] AID - 10.3389/fnut.2026.1763759 [doi] PST - epublish SO - Front Nutr. 2026 Feb 17;13:1763759. doi: 10.3389/fnut.2026.1763759. eCollection 2026. PMID- 41783638 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1815-672X (Electronic) IS - 0028-2715 (Print) IS - 0028-2715 (Linking) VI - 63 IP - 290 DP - 2025 Oct TI - Human Milk Banking In Nepal: An Initiative To Strengthen Newborn Nutrition. PG - 783-786 LID - 10.31729/jnma.v63i290.9198 [doi] AB - To address the gap in suboptimal breastfeeding practices and limited access to human milk and its challenges to neonatal health outcomes, the country's first Human Milk Bank, "Amrit Kosh," was established at Paropakar Maternity and Women's Hospital (PMWH) in August 2022. This study presents the experience of its operation, highlighting development, induction, challenges, and future directions for the program. Data were extracted from Human Milk Bank procedure records. Standard quality assurance protocols were followed throughout milk handling and processing, adhering to national guidelines. Of 2859 willing donors, 2820 mothers met eligibility criteria, contributing 1760.35 liters of breast milk. All batches of pasteurized donor human milk (PDHM) passed bacteriological screening, ensuring zero contamination, which was dispensed to 3511 neonates. The successful establishment and safe operation of Nepal's first Human Milk Bank demonstrate the feasibility and impact in a resource-limited setting. Future priorities include securing sustainable funding, expanding community engagement, and scaling the model to other facilities. "Amrit Kosh" has provided critical nutrition while enhancing breastfeeding awareness. CI - (c) The Author(s) 2025. FAU - Poudel, Smriti AU - Poudel S AD - Paropakar Maternity and Women's Hospital, Thapathali, Kathmandu, Nepal. FAU - Subedi, Kalpana Upadhaya AU - Subedi KU AD - Paropakar Maternity and Women's Hospital, Thapathali, Kathmandu, Nepal. FAU - Karmacharya, Shailendra Bir AU - Karmacharya SB AD - Paropakar Maternity and Women's Hospital, Thapathali, Kathmandu, Nepal. FAU - Paudel, Prajwal AU - Paudel P AD - Paropakar Maternity and Women's Hospital, Thapathali, Kathmandu, Nepal. FAU - Shrestha, Rina AU - Shrestha R AD - Paropakar Maternity and Women's Hospital, Thapathali, Kathmandu, Nepal. FAU - Maharjan, Punam AU - Maharjan P AD - Paropakar Maternity and Women's Hospital, Thapathali, Kathmandu, Nepal. FAU - Prajapati, Laxmiswori AU - Prajapati L AD - Paropakar Maternity and Women's Hospital, Thapathali, Kathmandu, Nepal. LA - eng PT - Journal Article DEP - 20250901 PL - Nepal TA - JNMA J Nepal Med Assoc JT - JNMA; journal of the Nepal Medical Association JID - 0045233 SB - IM MH - Humans MH - *Milk Banks/organization & administration/standards MH - Nepal MH - Infant, Newborn MH - *Milk, Human/microbiology MH - *Breast Feeding MH - Female MH - *Infant Nutritional Physiological Phenomena PMC - PMC12860669 OTO - NOTNLM OT - breastfeeding OT - human milk OT - milk banking COIS- Though, the author is the manager of the program and oversees overall functions of the Human Milk Bank, no data manipulation and selective reporting of the program is made. Hence, no conflict of interest to disclose. EDAT- 2026/03/05 07:09 MHDA- 2026/03/07 01:37 PMCR- 2025/10/01 CRDT- 2026/03/05 04:56 PHST- 2025/06/26 00:00 [received] PHST- 2025/07/26 00:00 [revised] PHST- 2025/09/25 00:00 [accepted] PHST- 2026/03/07 01:37 [medline] PHST- 2026/03/05 07:09 [pubmed] PHST- 2026/03/05 04:56 [entrez] PHST- 2025/10/01 00:00 [pmc-release] AID - 10.31729/jnma.v63i290.9198 [doi] PST - ppublish SO - JNMA J Nepal Med Assoc. 2025 Oct;63(290):783-786. doi: 10.31729/jnma.v63i290.9198. Epub 2025 Sep 1. PMID- 41782980 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1815-672X (Electronic) IS - 0028-2715 (Print) IS - 0028-2715 (Linking) VI - 63 IP - 292 DP - 2025 Dec TI - Anthropometric Study of the Human Ear Among Patients Visiting People's Dental College and Hospital: An Observational Study. PG - 894-897 LID - 10.31729/jnma.v63i292.9249 [doi] AB - INTRODUCTION: Anthropometric measurements of the external ear provide valuable normative data for applications in clinical practice, reconstructive surgery, forensics, and ergonomics. As ear morphology varies by population, sex, and age, population-specific reference data are essential. This study aimed to determine the normal dimensions of the outer ear among adult patients. METHODS: A cross-sectional study was conducted from 8th to 28th September 2025 among 157 adult patients (82 males and 75 females) visiting the hospital with normal external ears. Standardized auricular measurements, including auricular height, auricular width, lobular height, and lobular width, were obtained bilaterally using a digital vernier caliper following established anthropometric landmarks. Data were analyzed using descriptive statistics to calculate the mean and standard deviation. RESULTS: The mean right and left auricular heights were 63.38 +/- 6.19 mm and 63.13 +/- 6.49 mm, respectively, while auricular widths were 33.81 +/- 6.26 mm (right) and 33.82 +/- 6.23 mm (left). Minimal bilateral asymmetry was observed. Males exhibited greater auricular height and width, whereas females showed marginally larger lobular dimensions. Lobular height demonstrated greater variability than width across both sexes. CONCLUSION: The study revealed strong bilateral symmetry in external ear measurements, with clear sexual dimorphism-males having larger auricular dimensions and females slightly larger lobules. This finding provide baseline data for Nepalese adults and hold relevance in forensic identification, prosthetic design, and reconstructive surgery. Further large-scale, multiethnic studies are recommended to validate and expand upon these findings. CI - (c) The Author(s) 2025. FAU - Bajracharya, Mangesh AU - Bajracharya M AD - Department of Anatomy, People's Dental College and Hospital, Nayabazar, Kathmandu, Nepal. FAU - Maharjan, Shyam Kaji AU - Maharjan SK AD - Department of Prosthodontics, People's Dental College and Hospital, Nayabazar, Kathmandu, Nepal. FAU - Shrestha, Dristi AU - Shrestha D AD - Department of Anatomy, People's Dental College and Hospital, Nayabazar, Kathmandu, Nepal. FAU - Pathak, Chetana AU - Pathak C AD - Department of ENT, People's Dental College and Hospital, Nayabazar, Kathmandu, Nepal. LA - eng PT - Journal Article PT - Observational Study DEP - 20251231 PL - Nepal TA - JNMA J Nepal Med Assoc JT - JNMA; journal of the Nepal Medical Association JID - 0045233 SB - IM MH - Humans MH - Female MH - Male MH - Adult MH - Cross-Sectional Studies MH - *Anthropometry/methods MH - Nepal MH - *Ear, External/anatomy & histology MH - Young Adult MH - Middle Aged MH - Reference Values MH - Adolescent MH - Sex Characteristics MH - Sex Factors PMC - PMC12906748 OTO - NOTNLM OT - anthropometry OT - auricular dimensions OT - sexual dimorphism COIS- None. EDAT- 2026/03/05 07:09 MHDA- 2026/03/07 06:39 PMCR- 2025/12/01 CRDT- 2026/03/05 04:47 PHST- 2025/10/18 00:00 [received] PHST- 2025/10/25 00:00 [revised] PHST- 2025/11/26 00:00 [accepted] PHST- 2026/03/07 06:39 [medline] PHST- 2026/03/05 07:09 [pubmed] PHST- 2026/03/05 04:47 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - 10.31729/jnma.v63i292.9249 [doi] PST - ppublish SO - JNMA J Nepal Med Assoc. 2025 Dec;63(292):894-897. doi: 10.31729/jnma.v63i292.9249. Epub 2025 Dec 31. PMID- 41782651 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260305 LR - 20260813 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 3 DP - 2026 Mar TI - Sensor-Equipped Digital Technologies for Monitoring and Detecting Depressive Disorders: A Systematic Review. PG - e71743 LID - 10.1002/hsr2.71743 [doi] LID - e71743 AB - BACKGROUND AND AIMS: Depression is a common and chronic mental health problem, and the diagnosis and management of depression require continuous monitoring. In this review study, sensor-based digital tools for the diagnosis and management of depression were examined. The effectiveness, usability, and limitations of these tools were evaluated and discussed. METHODS: This systematic review was conducted in November 2025 using databases including IEEE, PubMed, Scopus, and Web of Science. The search was performed in accordance with PRISMA guidelines. Peer-reviewed studies that had used digital technologies for the diagnosis, monitoring, or intervention in depression were identified. Eligible articles were included in the study after full-text assessment. RESULTS: In total, 41 studies met the inclusion criteria. Sample sizes in the studies ranged from 5 to 3936 participants. The study populations covered a wide range, from adolescents to older adults. Most investigations addressed various depressive disorders; some also referred to bipolar disorders or psychological distress. Overall, digital tools were categorized into smartphones, wearables, hybrid systems, and innovative platforms. These tools often used sensors such as global positioning systems (GPS), accelerometers, and heart rate monitors. Speech and facial analyzers were also employed. Data collection was carried out through active and passive monitoring of behavior, physiology, and mood. CONCLUSION: Sensor-based digital tools have the capability to monitor and record the complex symptoms of depression. These data can also be used for personalized care. However, robust and standardized validation is required for clinical implementation. Future research should focus on long-term engagement and scalability of these tools while maintaining confidentiality and sensitivity, with an emphasis on specific types of depression. CI - (c) 2026 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Rahimi, Milad AU - Rahimi M AD - Health and Biomedical Informatics Research Center Urmia University of Medical Sciences Urmia Iran. AD - Department of Medical Informatics, School of Allied Medical Sciences Urmia University of Medical Sciences Urmia Iran. FAU - Abrishamifar, Kimia AU - Abrishamifar K AD - Department of Health Information Management, School of Management & Information Sciences Shiraz University of Medical Science Shiraz Iran. FAU - Hazhir, Shadi AU - Hazhir S AD - Department of Health Information Technology and Management, School of Allied Medical Sciences Shahid Beheshti University of Medical Sciences Tehran Iran. FAU - Valizadeh, Hossein AU - Valizadeh H AD - Department of Health Information Management, School of Health Management and Information Sciences Iran University of Medical Sciences Tehran Iran. FAU - Nourani, Aynaz AU - Nourani A AUID- ORCID: 0000-0001-5010-9774 AD - Health and Biomedical Informatics Research Center Urmia University of Medical Sciences Urmia Iran. AD - Department of Medical Informatics, School of Allied Medical Sciences Urmia University of Medical Sciences Urmia Iran. FAU - Rahimi, Bahlol AU - Rahimi B AUID- ORCID: 0000-0003-4927-1664 AD - Health and Biomedical Informatics Research Center Urmia University of Medical Sciences Urmia Iran. AD - Department of Medical Informatics, School of Allied Medical Sciences Urmia University of Medical Sciences Urmia Iran. LA - eng PT - Journal Article PT - Review DEP - 20260302 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC12953198 OTO - NOTNLM OT - depression OT - mental health OT - sensor OT - smartphone OT - wearable COIS- The authors declare no conflicts of interest. EDAT- 2026/03/05 07:09 MHDA- 2026/03/05 07:10 PMCR- 2026/03/02 CRDT- 2026/03/05 04:44 PHST- 2025/04/01 00:00 [received] PHST- 2025/12/10 00:00 [revised] PHST- 2026/01/03 00:00 [accepted] PHST- 2026/03/05 07:10 [medline] PHST- 2026/03/05 07:09 [pubmed] PHST- 2026/03/05 04:44 [entrez] PHST- 2026/03/02 00:00 [pmc-release] AID - HSR271743 [pii] AID - 10.1002/hsr2.71743 [doi] PST - epublish SO - Health Sci Rep. 2026 Mar 2;9(3):e71743. doi: 10.1002/hsr2.71743. eCollection 2026 Mar. PMID- 41782282 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260729 IS - 1440-172X (Electronic) IS - 1322-7114 (Linking) VI - 32 IP - 2 DP - 2026 Apr TI - Empowering New Mothers: A Randomized Trial Exploring the Effect of a Nursing Educational Programme on Breastfeeding Practices and Self-Efficacy Among Primigravida in Saudi Arabia. PG - e70119 LID - 10.1111/ijn.70119 [doi] AB - INTRODUCTION: Breastfeeding is vital for the health of both the mother and the child, but many primigravida, or first-time mothers, encounter obstacles that affect their ability to successfully breastfeed. AIM: This study sought to explore the impact of a health educational programme on breastfeeding practices and maternal self-efficacy. METHODS: A randomized controlled intervention design was employed, with participants allocated to either a control group or a study group receiving the educational programme. The study was conducted at the Maternal and Children Hospital in the Saudi Arabian cities of Hail and Bisha. A total of 442 primigravida mothers were enrolled, with 221 assigned to the study group and 221 to the control group. Data collection utilized the Self-Efficacy Scale Short-Form and a validated questionnaire assessing breastfeeding knowledge, attitude and practices (KAP). Each woman completed a structured interview and observations at five time points: pre-intervention (within the first week post-partum), post-intervention (2-3 weeks post-partum) and at 2, 4 and 6 months. RESULTS: The study group showed statistically significant improvements in total KAP scores compared to the control group (p < 0.001). Self-efficacy increased significantly in the study group, with more women reporting high self-efficacy at 2 months (25.2%), 4 months (45.1%) and 6 months (50.5%). CONCLUSION: A breastfeeding educational programme is a powerful tool for new mothers, enhancing practical skills and self-efficacy, leading to a more positive and sustained breastfeeding experience, supporting maternal and infant health outcomes. TRIAL REGISTRATION: ClinicalTrials.gov: NCT06423534. CI - (c) 2026 John Wiley & Sons Australia, Ltd. FAU - AlAbd, Asmaa Mohamed Ali AU - AlAbd AMA AUID- ORCID: 0000-0003-4506-4561 AD - Mental Health Nursing Department, College of Nursing, University of Hail, Hail, Saudi Arabia. FAU - Marzouk, Salwa Ali AU - Marzouk SA AD - Maternal and Child Health Nursing Department, College of Nursing, University of Hail, Hail, Saudi Arabia. FAU - Hassan, Aziza Ibrahim Mohamed AU - Hassan AIM AD - Nursing Department, College of Applied Medical Science, University of Bisha, Bisha, Saudi Arabia. FAU - Khedr, Mahmoud Abdelwahab AU - Khedr MA AUID- ORCID: 0000-0003-3437-3764 AD - College of Nursing, University of Hafr Albatin, Hafr Albatin, Saudi Arabia. FAU - Albaqawi, Hamdan Mohamed AU - Albaqawi HM AUID- ORCID: 0000-0001-9749-9669 AD - Medical and Surgical Department, College of Nursing, University of Hail, Hail, Saudi Arabia. FAU - Alrashidi, Nojoud Abdullah AU - Alrashidi NA AD - Maternal and Child Health Nursing Department, College of Nursing, University of Hail, Hail, Saudi Arabia. FAU - Alshammari, Layla Salem AU - Alshammari LS AD - Medical and Surgical Department, College of Nursing, University of Hail, Hail, Saudi Arabia. FAU - Buta, Joyce B AU - Buta JB AD - Maternal and Child Health Nursing Department, College of Nursing, University of Hail, Hail, Saudi Arabia. FAU - Al Nawasreh, Sarah Sulieman AU - Al Nawasreh SS AD - Maternal and Child Health Nursing Department, College of Nursing, University of Hail, Hail, Saudi Arabia. LA - eng SI - ClinicalTrials.gov/NCT06423534 GR - RG-23 254/University of Hail/ PT - Journal Article PT - Randomized Controlled Trial PL - Australia TA - Int J Nurs Pract JT - International journal of nursing practice JID - 9613615 SB - IM MH - Humans MH - Female MH - Saudi Arabia MH - *Breast Feeding MH - *Self Efficacy MH - Adult MH - *Mothers/psychology/education MH - *Power, Psychological MH - *Gravidity OTO - NOTNLM OT - breastfeeding OT - health educational programme OT - midwifery OT - nursing OT - primigravida OT - self-efficacy EDAT- 2026/03/05 07:09 MHDA- 2026/03/07 18:38 CRDT- 2026/03/05 01:23 PHST- 2026/02/14 00:00 [revised] PHST- 2025/03/08 00:00 [received] PHST- 2026/02/17 00:00 [accepted] PHST- 2026/03/07 18:38 [medline] PHST- 2026/03/05 07:09 [pubmed] PHST- 2026/03/05 01:23 [entrez] AID - 10.1111/ijn.70119 [doi] PST - ppublish SO - Int J Nurs Pract. 2026 Apr;32(2):e70119. doi: 10.1111/ijn.70119. PMID- 41782200 OWN - NLM STAT- MEDLINE DCOM- 20261019 LR - 20261020 IS - 1467-1107 (Electronic) IS - 1047-9511 (Linking) VI - 36 IP - 3 DP - 2026 Mar TI - Awareness and practice of physical activity in Omani children with CHDs: a cross-sectional study. PG - 459-462 LID - 10.1017/S1047951125110366 [doi] AB - BACKGROUND: CHDs, affecting 1.1% of newborns, are the most prevalent congenital anomalies. Improved survival rates expose children with CHD to long-term risks such as metabolic and acquired cardiovascular disorders. Despite physical activity's benefits, participation is often limited by real and perceived safety concerns. This study evaluates awareness and practice of physical activity among Omani children with CHD. AIM: To quantify physical activity levels and identify influencing factors in Omani children with CHD. METHODS: This cross-sectional study, conducted at major Omani paediatric cardiology centres, surveyed parents of children aged 5-18 years with CHD attending clinics from January 2019 to January 2023. A validated questionnaire assessed activity levels and influencing factors. Children with recent surgery (<3 months), single ventricle, cardiomyopathies, or without parental consent were excluded. RESULTS: Among 412 children, mean weekly physical activity was 2.18 hours. Parental participation in sports (beta = 0.42, p < 0.001) and cardiologist encouragement (beta = 0.38, p < 0.001) significantly increased activity levels. Children in houses (64% participation) were more active than those in apartments (34%, p = 0.004). Acyanotic CHD was associated with higher participation (66%) than cyanotic CHD (45%). Gender, parental education, and surgical history were not significant predictors. CONCLUSION: Omani children with CHD engage in insufficient physical activity. Parental involvement and cardiologist guidance are critical drivers. We recommend targeted educational programmes and routine exercise counselling to enhance participation. FAU - Al-Awidi, Osama AU - Al-Awidi O AUID- ORCID: 0009-0004-9435-4279 AD - Child Health, SQU, Oman. ROR: https://ror.org/04wq8zb47 AD - Pediatrics, OMSB, Oman. FAU - Al Abri, Issam AU - Al Abri I AD - College of Medicine & Health Sciences, SQU, Oman. FAU - Al-Subhi, Ahmed AU - Al-Subhi A AD - College of Medicine & Health Sciences, SQU, Oman. FAU - Joshi, Narinjan AU - Joshi N AD - Child Health, SQU, Oman. ROR: https://ror.org/04wq8zb47 FAU - Powell, Adam AU - Powell A AD - Pediatric Cardiology, Cincinnati Children's Hospital Medical Center Heart Institute, USA. FAU - Al Sinidi, Khalfan AU - Al Sinidi K AD - Child Health, SQU, Oman. ROR: https://ror.org/04wq8zb47 FAU - Al Balushi, Asim AU - Al Balushi A AUID- ORCID: 0000-0002-2803-2587 AD - Paediatric Cardiology, National Heart Centre, Oman. FAU - Al Riyami, Hilal AU - Al Riyami H AD - Child Health, SQU, Oman. ROR: https://ror.org/04wq8zb47 AD - Pediatrics, SQUH, Muscat, Oman. ROR: https://ror.org/049xx5c95 LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260305 PL - England TA - Cardiol Young JT - Cardiology in the young JID - 9200019 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Male MH - Oman/epidemiology MH - Child MH - Child, Preschool MH - Adolescent MH - *Exercise/physiology MH - *Heart Defects, Congenital/epidemiology/physiopathology MH - *Health Knowledge, Attitudes, Practice MH - Surveys and Questionnaires MH - *Parents/psychology OTO - NOTNLM OT - CHD OT - Oman OT - cardiologist guidance OT - caregiver awareness OT - paediatrics OT - physical activity EDAT- 2026/03/05 07:09 MHDA- 2026/10/19 05:30 CRDT- 2026/03/05 00:12 PHST- 2026/10/19 05:30 [medline] PHST- 2026/03/05 07:09 [pubmed] PHST- 2026/03/05 00:12 [entrez] AID - S1047951125110366 [pii] AID - 10.1017/S1047951125110366 [doi] PST - ppublish SO - Cardiol Young. 2026 Mar;36(3):459-462. doi: 10.1017/S1047951125110366. Epub 2026 Mar 5. PMID- 41781682 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 4 TI - Predictors of exercise participation among Saudi adults attending primary healthcare centers in Riyadh. LID - 10.1038/s41598-026-42374-6 [doi] LID - 11990 AB - Background Regular exercise is crucial for preventing chronic diseases. Saudi Arabia, undergoing rapid socioeconomic transformation, faces escalating rates of lifestyle-related illnesses, underscoring the urgent need to understand exercise participation among its residents. This study aims to identify key sociodemographic and health-related predictors of exercise engagement in this unique context, thereby informing targeted public health strategies. Methods This cross-sectional survey was conducted from March to July 2023 across 48 primary healthcare centers in Riyadh, Saudi Arabia, selected via multi-stage cluster sampling. A total of 14,239 adults (aged >/= 18) completed an electronic, interview-based questionnaire. A rigorously validated and reliable questionnaire collected self-reported data on sociodemographic characteristics, health behaviors and comorbidities. Univariate and multivariate logistic regression were used to identify predictors of exercise participation, with a p-value < 0.05 considered statistically significant in the adjusted model. Results Overall, a substantial 60.7% of participants reported engaging in regular exercise. Male sex was found to be a strong predictor (AOR = 1.14, 95% CI: 1.06-1.22, P = 0.001). Employed individuals were more likely to exercise (AOR = 1.40, 95% CI: 1.30-1.51, P < 0.001) than unemployed Saudi residents. The strongest predictor was health insurance coverage (AOR = 1.61, 95% CI: 1.48-1.75, P < 0.001). Smoking (AOR = 5.42, 95% CI: 4.82-6.08, P < 0.001) and fast-food consumption (AOR = 10.76, 95% CI: 9.77-11.84, P < 0.001) were also associated with higher odds of exercise. Individuals with heart disease showed significantly higher odds of exercising (AOR = 1.85, 95% CI: 1.42-2.41, P < 0.001). Conclusion Our findings underscore the complex interplay of sociodemographic factors, health behaviors, and existing health conditions in shaping exercise participation in Saudi Arabia. The significant influence of male sex, employment, insurance coverage, and the intriguing relationships with smoking, fast-food consumption, and specific health conditions, provide crucial insights. These results highlight key areas for developing tailored public health strategies and interventions to enhance exercise participation in Saudi Arabia. FAU - Al-Khateeb, Badr F AU - Al-Khateeb BF AUID- ORCID: 0000-0001-9824-7148 AD - King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. AD - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. AD - Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia. FAU - Shubair, Mamdouh M AU - Shubair MM AUID- ORCID: 0000-0003-4758-072X AD - Faculty of Human and Health Sciences (FHHS), School of Health Sciences, University of Northern British Columbia (UNBC), 3333 University Way, Prince George, BC, V2N 4Z9, Columbia, Canada. mamdouh.shubair@unbc.ca. FAU - Elmetwally, Mariam A A AU - Elmetwally MAA AD - Department of Psychology and Global One Health Academy, North Carolina State University, Raleigh, NC, USA. FAU - Alharthy, Amani AU - Alharthy A AUID- ORCID: 0000-0003-2668-6058 AD - Department of Health Science, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Zaidan, Amal Mousa AU - Zaidan AM AUID- ORCID: 0000-0003-4838-9281 AD - King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. AD - Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia. AD - College of Public Health & Health Informatics, King Saud Bin, Abdulaziz University for Health Science, Riyadh, Saudi Arabia. FAU - Alshahrani, Awad AU - Alshahrani A AUID- ORCID: 0000-0001-8266-6145 AD - King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. AD - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. AD - Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia. FAU - Angawi, Khadijah AU - Angawi K AUID- ORCID: 0000-0002-7625-1813 AD - Faculty of Economics and Administration, Department of Health Services and Hospital Administration, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Aldubikhi, Aljohrah Ibrahim AU - Aldubikhi AI AUID- ORCID: 0000-0001-6795-5029 AD - College of Health Sciences, Saudi Electronic University, Riyadh, Saudi Arabia. FAU - Sannaa, Faisal AU - Sannaa F AD - College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. FAU - Aldahan, Sara Mohammed AU - Aldahan SM AUID- ORCID: 0009-0008-1580-303X AD - Health Education Department, Health Education Specialist, Prince Mohammed Bin Fahad Hospital for Blood Diseases, Eastern Health Cluster, Eastern Province, Al Qatif, Saudi Arabia. FAU - Aldahash, Raed AU - Aldahash R AUID- ORCID: 0000-0001-9612-4072 AD - King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. AD - College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. AD - Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia. FAU - Alnaim, Lubna AU - Alnaim L AUID- ORCID: 0009-0002-3786-2379 AD - King Abdullah International Medical Research Center, Riyadh, Saudi Arabia. AD - Ministry of the National Guard-Health Affairs, Riyadh, Saudi Arabia. AD - College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Al Ahsa, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260304 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Male MH - Saudi Arabia MH - Female MH - *Exercise MH - Adult MH - *Primary Health Care/statistics & numerical data MH - Middle Aged MH - Cross-Sectional Studies MH - *Health Behavior MH - Surveys and Questionnaires MH - Young Adult MH - Socioeconomic Factors MH - Adolescent MH - Aged PMC - PMC13068885 OTO - NOTNLM OT - Exercise participation OT - Health behaviors OT - Predictors OT - Saudi Arabia OT - Sociodemographic COIS- Declarations. Competing Interests: The authors declare no competing interests. Ethics approval and consent to participate: "The ethical approval for the current study was taken from Intuitional Review Board of King Fahad medical city (approval # 22-397E). The study was conducted in accordance with the Declaration of Helsinki. The written informed consent to participate were taken from all participants before the data collection process.". EDAT- 2026/03/05 00:39 MHDA- 2026/06/27 06:45 PMCR- 2026/03/04 CRDT- 2026/03/04 23:25 PHST- 2025/11/04 00:00 [received] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/06/27 06:45 [medline] PHST- 2026/03/05 00:39 [pubmed] PHST- 2026/03/04 23:25 [entrez] PHST- 2026/03/04 00:00 [pmc-release] AID - 10.1038/s41598-026-42374-6 [pii] AID - 42374 [pii] AID - 10.1038/s41598-026-42374-6 [doi] PST - epublish SO - Sci Rep. 2026 Mar 4;16(1):11990. doi: 10.1038/s41598-026-42374-6. PMID- 41780730 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 123 IP - 5 DP - 2026 May TI - Ultraprocessed foods consumption and risk of preeclampsia: a secondary analysis of the improving mothers for a better prenatal care trial Barcelona (IMPACT BCN) randomized clinical trial. PG - 101255 LID - S0002-9165(26)00064-X [pii] LID - 10.1016/j.ajcnut.2026.101255 [doi] LID - 101255 AB - BACKGROUND: Preeclampsia is a pregnancy-specific condition affecting 2%-8% of pregnant females and a leading cause of maternal and perinatal morbimortality. High ultraprocessed food (UPF) consumption has been associated with the development of noncommunicable chronic diseases, but evidence on pregnancy outcomes is scarce. OBJECTIVES: To study the association of maternal UPF consumption and the risk of preeclampsia. METHODS: This study is a secondary analysis of the IMPACT BCN, a randomized clinical trial including 1221 pregnant females at high risk for small for gestational age newborns, conducted in Barcelona, Spain. Among these, 812 participants with complete dietary data at 2 timepoints during pregnancy (between weeks 19-23 of gestation and weeks 34-36 of gestation) were included in this analysis and classified into tertiles of change in UPF consumption during pregnancy. Dietary UPF consumption was assessed using NOVA classification with a validated 151-item food frequency questionnaire. Preeclampsia was defined as high blood pressure plus targeted organ involvement. Analyses were performed using logistic regression models adjusted for potential confounding factors. RESULTS: Associations between change of UFP consumption during pregnancy and overall preeclampsia were observed across tertiles [odds ratio (OR)(T3 compared with T1): 2.29; 95% confidence interval (CI): 1.06, 4.97, P-trend 0.026], but not when UPF change was modeled as a continuous variable [OR: 1.04; 95% CI: 0.95, 1.14]. Among UPF subclasses, pre-prepared dishes were significantly associated with preeclampsia risk [OR(T3 compared with T1): 2.36; 95% CI: 1.09, 5.12]. CONCLUSIONS: In a high-risk population, a higher change in dietary intake of UPF consumption from the second to third trimester of pregnancy was associated with a higher risk of preeclampsia. This trial was registered at clinicaltrials.gov as NCT03166332. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Trejo-Dominguez, Alejandra AU - Trejo-Dominguez A AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut de Recerca Sant Joan de Deu, Esplugues de Llobregat, Barcelona, Spain. FAU - Benitez, Leticia AU - Benitez L AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. FAU - Crovetto, Francesca AU - Crovetto F AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut de Recerca Sant Joan de Deu, Esplugues de Llobregat, Barcelona, Spain; Spanish Network in Maternal, Neonatal, Child and Developmental Health Research, RICORS-SAMID, RD24/0013/0004, Instituto de Salud Carlos III, Madrid, Spain; Departament de Ciencies Cliniques, Facultat de Medicina i Ciencies de la Salut, Universitat de Barcelona, Barcelona, Spain. Electronic address: francesca.crovetto@sjd.es. FAU - Casas, Rosa AU - Casas R AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Madrid, Spain; Institut de Recerca en Nutricio i Seguretat Alimentaria (INSA-UB), University of Barcelona, Barcelona, Spain; Department of Internal Medicine Hospital Clinic, University of Barcelona, Barcelona, Spain. Electronic address: rcasas1@recerca.clinic.cat. FAU - Youssef, Lina AU - Youssef L AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. FAU - Larroya, Marta AU - Larroya M AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Dexeus Mujer (Hospital Universitari Dexeus), Barcelona, Spain. FAU - Ruiz-Leon, Ana Maria AU - Ruiz-Leon AM AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Madrid, Spain; Institut de Recerca en Nutricio i Seguretat Alimentaria (INSA-UB), University of Barcelona, Barcelona, Spain; Department of Internal Medicine Hospital Clinic, University of Barcelona, Barcelona, Spain. FAU - Nakaki, Ayako AU - Nakaki A AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. FAU - Genero, Mariona AU - Genero M AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut de Recerca Sant Joan de Deu, Esplugues de Llobregat, Barcelona, Spain; Spanish Network in Maternal, Neonatal, Child and Developmental Health Research, RICORS-SAMID, RD24/0013/0004, Instituto de Salud Carlos III, Madrid, Spain. FAU - Casas, Irene AU - Casas I AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain. FAU - Novoa, Rommy H AU - Novoa RH AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain. FAU - Encabo, Noelia AU - Encabo N AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut de Recerca Sant Joan de Deu, Esplugues de Llobregat, Barcelona, Spain; Spanish Network in Maternal, Neonatal, Child and Developmental Health Research, RICORS-SAMID, RD24/0013/0004, Instituto de Salud Carlos III, Madrid, Spain. FAU - Rahman, Michael AU - Rahman M AD - Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. FAU - Wang, Xiaosuo AU - Wang X AD - Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia. FAU - O'Sullivan, John F AU - O'Sullivan JF AD - Charles Perkins Centre, School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia; CardioMetabolic Medicine Laboratory, The University of Sydney, Camperdown, New South Wales, Australia; School of Medical Sciences, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia; Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia; Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, Australia; Department of Medicine, TU Dresden, Helmholtzstr, Dresden, Germany. FAU - Hegarty, Narelle R AU - Hegarty NR AD - ANSTO, Lucas Heights, New South Wales, Australia. FAU - Vieta, Eduard AU - Vieta E AD - Department of Psychiatry and Psychology, Hospital Clinic, Neuroscience Institute, University of Barcelona, IDIBAPS, Center for Biomedical Research on Mental Health (CIBERSAM), Barcelona, Spain. FAU - Gratacos, Eduard AU - Gratacos E AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut de Recerca Sant Joan de Deu, Esplugues de Llobregat, Barcelona, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centre for Biomedical Research on Rare Diseases (CIBERER), Barcelona, Spain. FAU - Estruch, Ramon AU - Estruch R AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Madrid, Spain; Institut de Recerca en Nutricio i Seguretat Alimentaria (INSA-UB), University of Barcelona, Barcelona, Spain; Department of Internal Medicine Hospital Clinic, University of Barcelona, Barcelona, Spain. FAU - Crispi, Fatima AU - Crispi F AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centre for Biomedical Research on Rare Diseases (CIBERER), Barcelona, Spain. FAU - Castro-Barquero, Sara AU - Castro-Barquero S AD - BCNatal, Barcelona Center for Maternal and Fetal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain; Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Madrid, Spain; Institut de Recerca en Nutricio i Seguretat Alimentaria (INSA-UB), University of Barcelona, Barcelona, Spain. LA - eng SI - ClinicalTrials.gov/NCT03166332 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260302 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Adult MH - Female MH - Humans MH - Infant, Newborn MH - Pregnancy MH - Young Adult MH - *Diet MH - Food, Processed MH - *Pre-Eclampsia/etiology/epidemiology MH - *Prenatal Care MH - Risk Factors MH - Spain/epidemiology MH - Secondary Data Analysis PMC - PMC13197901 OTO - NOTNLM OT - Mediterranean diet OT - preeclampsia OT - pregnancy OT - prenatal OT - ultraprocessed foods COIS- Conflict of interest RE reports grants from the Fundacion Dieta Mediterranea (Spain), and Cerveza y Salud (Spain), and personal fees for given lectures from Brewers of Europe (Belgium), the Fundacion Cerveza y Salud (Spain), Pernaud-Ricard (Mexico), Instituto Cervantes (Alburquerque, United States), Instituto Cervantes (Milan, Italy), Instituto Cervantes (Tokyo, Japan), Lilly Laboratories (Spain), and the Wine and Culinary International Forum (Spain), as well as nonfinancial support for the organization of a National Congress on Nutrition and feeding trials with products from Grand Fountain and Uriach Laboratories (Spain). EV has received grants and served as consultant, advisor or CME speaker for the following entities: AB-Biotics, Abbott, AbbVie, Adamed, Alcediag, Angelini, Biogen, Beckley-Psytech, Biohaven, Boehringer-Ingelheim, Casen-Recordati, Celon Pharma, Compass, Dainippon Sumitomo Pharma, Esteve, Ethypharm, Ferrer, Gedeon Richter, GH Research, Glaxo-Smith Kline, HMNC, Idorsia, Johnson & Johnson, Lundbeck, Luye Pharma, Medincell, Merck, Mitsubishi Tanabe Pharma, Newron, Novartis, Organon, Orion Corporation, Otsuka, Roche, Rovi, Sage, Sanofi-Aventis, Sunovion, Takeda, Teva, and Viatris, outside the submitted work. The other authors report no conflicts of interest. EDAT- 2026/03/05 00:39 MHDA- 2026/05/04 00:31 PMCR- 2026/03/02 CRDT- 2026/03/04 19:13 PHST- 2025/07/15 00:00 [received] PHST- 2026/02/13 00:00 [revised] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/05/04 00:31 [medline] PHST- 2026/03/05 00:39 [pubmed] PHST- 2026/03/04 19:13 [entrez] PHST- 2026/03/02 00:00 [pmc-release] AID - S0002-9165(26)00064-X [pii] AID - 101255 [pii] AID - 10.1016/j.ajcnut.2026.101255 [doi] PST - ppublish SO - Am J Clin Nutr. 2026 May;123(5):101255. doi: 10.1016/j.ajcnut.2026.101255. Epub 2026 Mar 2. PMID- 41779566 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 1678-4561 (Electronic) IS - 1413-8123 (Linking) VI - 31 IP - 2 DP - 2026 Feb TI - Anthropometric parameters and altered blood pressure risk prediction in adolescents. PG - e02892024 LID - S1413-81232026000203004 [pii] LID - 10.1590/1413-81232026312.02892024 [doi] AB - Elevated blood pressure (EBP) or high blood pressure (HBP) has been frequently linked to excess weight in adolescents. This article aims to assess the association between altered blood pressure (ABP), including EBP and HBP, and anthropometric parameters. This cross-sectional study evaluated the association of ABP with waist circumference (WC), body mass index (BMI), and height-to-waist ratio (HWR) among adolescents aged between 13 and 18 years. Predictive performance for ABP was evaluated using receiver operating characteristic (ROC) curve analysis. The study comprised 328 individuals, 51% female, 23% overweight, and 10% obese. The median WC was 77 cm (interquartile range [IQR]: 77.3-84.3 cm), and the medin HWR was 0.46 (IQR: 0.44-0.51). EBP was found to be more prevalent among males (p = 0.01) and obese participants (p = 0.03), with higher HWR (p = 0.007) and WC (p < 0.001). Regarding the prediction of HBP, WC demonstrated a larger area under the curve (0.71) compared to HWR (0.64) (p = 0.02), although similar to BMI (0.65) (p = 0.14). Waist circumference, a readily obtainable measure, exhibited predictive performance comparable to other anthropometric parameters in assessing the risk for ABP in this sample of Brazilian adolescents. FAU - D'Amoreira, Rosilene D'Alascio AU - D'Amoreira RD AUID- ORCID: 0000-0002-5667-4210 AD - Instituto Federal de Educacao, Ciencia e Tecnologia Sul-Rio-Grandense (IF-Sul). R. Goncalves Chaves 3218, Centro. 96015-560. Rio Grande RS Brasil. rosilene.damoreira@riogrande.ifrs.edu.br. AD - Programa de Pos-Graduacao em Saude e Comportamento, Universidade Catolica de Pelotas. Pelotas RS Brasil. FAU - Dumith, Samuel de Carvalho AU - Dumith SC AUID- ORCID: 0000-0002-5994-735X AD - Programa Pos-Graduacao em Ciencias da Saude, Universidade Federal do Rio Grande. Rio Grande RS Brasil. FAU - Poma, Samy Ailey Mendez AU - Poma SAM AUID- ORCID: 0009-0004-7118-8466 AD - Programa de Pos-Graduacao em Saude e Comportamento, Universidade Catolica de Pelotas. Pelotas RS Brasil. FAU - Bohlke, Maristela AU - Bohlke M AUID- ORCID: 0000-0001-9372-3475 AD - Programa de Pos-Graduacao em Saude e Comportamento, Universidade Catolica de Pelotas. Pelotas RS Brasil. AD - Unidade de Dialise e Transplante Renal, Hospital Universitario Sao Francisco de Paula, Universidade Catolica de Pelotas. Pelotas RS Brasil. LA - eng PT - Journal Article DEP - 20241024 PL - Brazil TA - Cien Saude Colet JT - Ciencia & saude coletiva JID - 9713483 SB - IM MH - Humans MH - Adolescent MH - Female MH - Cross-Sectional Studies MH - *Hypertension/epidemiology/etiology MH - Male MH - *Waist Circumference MH - Body Mass Index MH - Risk Assessment MH - *Blood Pressure/physiology MH - Anthropometry EDAT- 2026/03/04 18:43 MHDA- 2026/03/07 06:39 CRDT- 2026/03/04 12:15 PHST- 2024/06/11 00:00 [received] PHST- 2024/10/22 00:00 [accepted] PHST- 2026/03/07 06:39 [medline] PHST- 2026/03/04 18:43 [pubmed] PHST- 2026/03/04 12:15 [entrez] AID - S1413-81232026000203004 [pii] AID - 10.1590/1413-81232026312.02892024 [doi] PST - ppublish SO - Cien Saude Colet. 2026 Feb;31(2):e02892024. doi: 10.1590/1413-81232026312.02892024. Epub 2024 Oct 24. PMID- 41777605 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260304 LR - 20260926 IS - 2673-4842 (Electronic) IS - 2673-4842 (Linking) VI - 7 DP - 2026 TI - A common risk factor strategy for combating childhood oral diseases and malnutrition in Kalpetta, India. PG - 1673066 LID - 10.3389/froh.2026.1673066 [doi] LID - 1673066 AB - AIM/PURPOSE: Childhood dental caries and malnutrition share a bi-directional relationship and represent significant public health challenges. This study aimed to evaluate the effectiveness of a Common Risk Factor Strategy-based intervention in improving childhood oral health and nutrition among preschool and primary school tribal children in Kerala, India. METHODS: This pre-post quasi-experimental study was conducted among tribal children and their caregivers. Baseline assessments included knowledge of oral health, childhood dental caries, and nutrition, along with evaluations of oral health and nutritional status using validated questionnaires and indices. The intervention comprised oral hygiene awareness, dietary counseling, caries prevention through fluoride varnish application, arrest of cavitated lesions using silver diamine fluoride (SDF), curative dental treatment, and the regular provision of toothpaste and toothbrushes. The effectiveness of these interventions was assessed after one year. RESULTS: A total of 95 children (mean age: 4.47 +/- 1.42 years) and their caregivers participated in the study. Post-intervention, there was a significant increase in mean KAP childhood caries assessed using 24 point scale [mean difference (MD): 14.52 +/- 5.01] and nutrition knowledge assessed using 10 point scale (MD: 3.67 +/- 3.42). The mean number of decayed teeth significantly decreased from 7.71 +/- 3.59 to 1.43 +/- 0.53, accompanied by notable improvements in oral hygiene and nutritional indicators. Among children under 5 years, weight-for-age and weight-for-length Z-scores improved significantly following the intervention (p < 0.05). CONCLUSIONS: This study highlights the effectiveness of an integrated medical-dental approach in addressing childhood oral health and malnutrition. Strengthening early prevention strategies through the Common Risk Factor Approach can serve as a sustainable model to improve overall child health and well-being in vulnerable populations. Prioritizing such holistic interventions in public health policies can be a game-changer in reducing health inequities. CI - (c) 2026 Janakiram, Ramanarayanan, James, Raj, Babu and Vasudevan. FAU - Janakiram, Chandrashekar AU - Janakiram C AD - Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, India. FAU - Ramanarayanan, Venkitachalam AU - Ramanarayanan V AD - Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, India. FAU - James, Anju AU - James A AD - Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, India. FAU - Raj, Arya S AU - Raj AS AD - Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, India. FAU - Babu, Anna Maria AU - Babu AM AD - Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, India. FAU - Vasudevan, Sanjeev AU - Vasudevan S AD - Amrita School of Dentistry, Amrita Vishwa Vidyapeetham, Kochi, India. LA - eng PT - Journal Article DEP - 20260216 PL - Switzerland TA - Front Oral Health JT - Frontiers in oral health JID - 9918227262706676 PMC - PMC12950718 OTO - NOTNLM OT - childhood dental caries OT - common risk factor approach OT - dental caries OT - malnutrition OT - oral health COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author CJ declares that he is an editorial board member of Frontiers at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/03/04 07:15 MHDA- 2026/03/04 07:16 PMCR- 2026/02/16 CRDT- 2026/03/04 04:28 PHST- 2025/07/25 00:00 [received] PHST- 2026/01/02 00:00 [revised] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/03/04 07:16 [medline] PHST- 2026/03/04 07:15 [pubmed] PHST- 2026/03/04 04:28 [entrez] PHST- 2026/02/16 00:00 [pmc-release] AID - 10.3389/froh.2026.1673066 [doi] PST - epublish SO - Front Oral Health. 2026 Feb 16;7:1673066. doi: 10.3389/froh.2026.1673066. eCollection 2026. PMID- 41776469 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Mar 4 TI - Assessment of tooth wear with intraoral scanned models in young adults. LID - 10.1186/s12903-026-08007-0 [doi] LID - 643 AB - OBJECTIVE: To investigate the prevalence of tooth wear (TW) and identify associated risk factors among undergraduate students using intraoral scanning (IOS) technology. METHODS: A cross-sectional study was conducted on 504 first- to third-year undergraduate students from various medical and health-related disciplines, selected by multistage stratified random sampling at Kunming Medical University. Participants underwent digital dental scans (TRIOS 5, 3Shape) and completed a validated questionnaire covering demographics, dietary habits, and medical history. Tooth wear was assessed by calibrated examiners (kappa > 0.79) using the Basic Erosive Wear Examination (BEWE) index on digital models. Statistical analyses included chi-square tests and multiple linear regression (SPSS 27.0), with significance set at p < 0.05. RESULTS: The study included students with a mean age of 20.58 (+/- 2.07) years. The overall TW prevalence (BEWE >/= 2) was 68.1%. In terms of severity, the majority of participants were classified as low risk (BEWE total scores 3-8: 82.9%). Severe wear (BEWE = 3) was most frequently observed in mandibular incisors (2.18-2.58%). Males exhibited significantly higher BEWE scores than females (p = 0.035). Factors statistically significantly associated with higher BEWE total scores included: frequent carbonated drink consumption (b = 1.044, 95% CI: 0.665-1.423), acidic fruit intake (b = 1.520, 95% CI: 1.031-2.008), bruxism (b = 0.973, 95% CI: 0.324-1.622), and gastroesophageal reflux (b = 0.741, 95% CI: 0.132-1.350). Conversely, coffee consumption (b = -0.568, 95% CI: -0.991- -0.145) and gum chewing (b = - 0.396, 95% CI: -0.730- -0.063) were statistically significantly associated with lower wear scores. CONCLUSION: Tooth wear is highly prevalent among undergraduates, with acidic diets, intrinsic factors (such as GERD), and parafunctional habits being significant factors associated with the condition. IOS technology facilitates detailed TW assessment for the early detection of wear patterns, supporting targeted preventive strategies in young populations. CLINICAL SIGNIFICANCE: High tooth wear prevalence in young adults underscores the urgency of routine screening. Identifying associations with acidic diet and bruxism supports personalized prevention. Furthermore, intraoral scanning serves as a sensitive tool for early monitoring, enabling timely intervention to limit progression. FAU - Jiang, Wenjie AU - Jiang W AD - Yunnan Key Laboratory of Stomatology and Department of Prosthodontics, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, 650106, China. FAU - Zhang, Min AU - Zhang M AD - Yunnan Key Laboratory of Stomatology and Department of Prosthodontics, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, 650106, China. FAU - Ou, Yi AU - Ou Y AD - Yunnan Key Laboratory of Stomatology and Department of Prosthodontics, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, 650106, China. FAU - Yang, Hefeng AU - Yang H AD - Yunnan Key Laboratory of Stomatology and Department of Prosthodontics, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, 650106, China. FAU - Qian, Jie AU - Qian J AD - Yunnan Key Laboratory of Stomatology and Department of Prosthodontics, The Affiliated Stomatology Hospital, Kunming Medical University, Kunming, 650106, China. FAU - Sheng, Xun AU - Sheng X AD - Yunnan Key Laboratory of Stomatology and The First Clinical Divison, The Affiliated Stomatology Hospital, Kunming Medical University, Building C, No. 1088 Haiyuan Zhonglu, Kunming, 650106, China. shengxun19yd@163.com. LA - eng GR - 202305AF150174/Tan Jianguo Expert Workstation of Yunnan Province/ GR - 2025S242/Graduate Education Innovation Fund of Kunming Medical University/ PT - Journal Article DEP - 20260304 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - Male MH - Female MH - Young Adult MH - *Tooth Wear/epidemiology/diagnostic imaging/etiology MH - Cross-Sectional Studies MH - Risk Factors MH - Prevalence MH - Adolescent MH - Tooth Erosion/epidemiology MH - Gastroesophageal Reflux/complications MH - Bruxism MH - Adult MH - Sex Factors PMC - PMC13067728 OTO - NOTNLM OT - Basic Erosive Wear Examination OT - Epidemiology OT - Erosive tooth wear OT - Intraoral scanning OT - Tooth wear COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Ethics Committee of the Hospital of Stomatology, Kunming Medical University (Approval No. KYKQ2025MEC0053). Written informed consent was obtained from all individual participants included in the study prior to data collection. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/03/04 01:17 MHDA- 2026/06/27 18:36 PMCR- 2026/03/04 CRDT- 2026/03/03 23:47 PHST- 2025/11/16 00:00 [received] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/06/27 18:36 [medline] PHST- 2026/03/04 01:17 [pubmed] PHST- 2026/03/03 23:47 [entrez] PHST- 2026/03/04 00:00 [pmc-release] AID - 10.1186/s12903-026-08007-0 [pii] AID - 8007 [pii] AID - 10.1186/s12903-026-08007-0 [doi] PST - epublish SO - BMC Oral Health. 2026 Mar 4;26(1):643. doi: 10.1186/s12903-026-08007-0. PMID- 41775779 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 3 TI - Global protein profiling of human milk using pre-enriched RNA-sequence libraries. LID - 10.1038/s41598-026-41374-w [doi] LID - 11827 AB - The complex protein composition of human milk remains challenging to characterize due to technical limitations, yet such insights are crucial as early-life nutrition influences long-term health outcomes and is associated with pathological conditions such as obesity. In this study, we applied APTASHAPE, a high-throughput profiling method based on chemically modified protein-binding RNA molecules, to globally profile protein composition in skimmed human milk and to explore associations with maternal and infant characteristics. A total of 520 human milk samples collected at 3 days, 1 month, 2 months, and 3 months postpartum were analyzed. Ordinary least squares regression analysis of the discovery cohort identified discriminatory RNA sequence profiles reflecting the global protein composition and correlating with sampling time, maternal BMI, and parity. These associations were subsequently validated and confirmed in an independent test cohort. Furthermore, 14 candidate aptamers were subjected to protein pull-down assays followed by mass spectrometry, which identified C4b-binding protein and tenascin C as candidate targets associated with maternal BMI and sampling time. Overall, our findings highlight the dynamic nature of the human milk protein composition, with the greatest variation attributable to sampling time, while maternal BMI and parity accounted for more subtle differences. CI - (c) 2026. The Author(s). FAU - Astono, Julie AU - Astono J AD - Department of Food Science, Aarhus University, Agro Food Park 48, Aarhus N, Denmark. FAU - Jorgensen, Asger Givskov AU - Jorgensen AG AD - Department of Molecular Biology and Genetics, Interdisciplinary Nanoscience Center, Aarhus University, Gustav Wieds Vej 14, Aarhus C, Denmark. asgergivskov@inano.au.dk. FAU - Bus, Claus AU - Bus C AD - Department of Molecular Biology and Genetics, Interdisciplinary Nanoscience Center, Aarhus University, Gustav Wieds Vej 14, Aarhus C, Denmark. FAU - Nielsen, Soren Drud-Heydary AU - Nielsen SD AD - Arla Food Ingredients, Sonderupvej 26, Videbaek, Denmark. FAU - Kjems, Jorgen AU - Kjems J AD - Department of Molecular Biology and Genetics, Interdisciplinary Nanoscience Center, Aarhus University, Gustav Wieds Vej 14, Aarhus C, Denmark. FAU - Sundekilde, Ulrik Kraemer AU - Sundekilde UK AD - Department of Food Science, Aarhus University, Agro Food Park 48, Aarhus N, Denmark. uksundekilde@food.au.dk. LA - eng GR - AUFF-E-2021-9-32/Aarhus Universitets Forskningsfond/ PT - Journal Article DEP - 20260303 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Milk Proteins) SB - IM MH - Humans MH - *Milk, Human/metabolism/chemistry MH - Female MH - *Milk Proteins/metabolism/genetics/analysis MH - *Gene Library MH - Adult MH - Body Mass Index MH - *Proteomics/methods PMC - PMC13066517 COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/03/04 01:17 MHDA- 2026/04/10 00:33 PMCR- 2026/03/03 CRDT- 2026/03/03 23:18 PHST- 2025/09/22 00:00 [received] PHST- 2026/02/19 00:00 [accepted] PHST- 2026/04/10 00:33 [medline] PHST- 2026/03/04 01:17 [pubmed] PHST- 2026/03/03 23:18 [entrez] PHST- 2026/03/03 00:00 [pmc-release] AID - 10.1038/s41598-026-41374-w [pii] AID - 41374 [pii] AID - 10.1038/s41598-026-41374-w [doi] PST - epublish SO - Sci Rep. 2026 Mar 3;16(1):11827. doi: 10.1038/s41598-026-41374-w. PMID- 41775761 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Mar 3 TI - Identifying neuromuscular and mental fatigue in elite youth table tennis players using machine learning. LID - 10.1038/s41598-026-40324-w [doi] LID - 11812 AB - Performance in table tennis is known to be affected by both mental and physical fatigue. However, accurately predicting a player's fatigue state remains challenging, particularly when using non-intrusive measurement protocols. This study proposes a methodology for detecting fatigue based on the analysis of players' movement patterns following controlled fatigue induction in young elite table tennis players. Player movements were recorded using an instrumented racket equipped with an accelerometer and pressure sensors. Mental and physical fatigue were induced using established protocols and were validated through significant changes in reference markers, including the Rating of Perceived Exertion for mental fatigue (p < 0.05) and Maximum Voluntary Contraction for physical fatigue (p < 0.05). The resulting labelled datasets were used to train supervised machine learning models for both binary fatigue detection and multiclass fatigue classification. Among the evaluated models, K-Nearest Neighbors and Random Forest achieved the best performance, with recognition rates of approximately 84% for binary classification and 82% for multiclass classification. These results demonstrate that combining formal fatigue induction with instrumented movement analysis enables the creation of reliable datasets for predicting players' fatigue states from their gestures. CI - (c) 2026. The Author(s). FAU - Delumeau, Thibault AU - Delumeau T AD - Nantes Universite, Oniris, CNRS, GEPEA, UMR 6144, F-44470, Carquefou, France. thibault.delumeau@univ-nantes.fr. FAU - Deschamps, Thibault AU - Deschamps T AD - Nantes Universite, Mouvement - Interactions - Performance, MIP, UR4334, F-44000, Nantes, France. FAU - Plot, Christophe AU - Plot C AD - Nantes Universite, Oniris, CNRS, GEPEA, UMR 6144, F-44470, Carquefou, France. FAU - Le Carpentier, Eric AU - Le Carpentier E AD - Nantes Universite, Ecole Centrale Nantes, CNRS, LS2N, UMR 6004, F-44000, Nantes, France. FAU - Mousseau, Pierre AU - Mousseau P AD - Nantes Universite, Oniris, CNRS, GEPEA, UMR 6144, F-44470, Carquefou, France. LA - eng PT - Journal Article DEP - 20260303 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Machine Learning MH - *Mental Fatigue/diagnosis/physiopathology MH - Male MH - *Racquet Sports/physiology MH - *Muscle Fatigue/physiology MH - *Tennis MH - Predictive Learning Models MH - *Athletes MH - Classification Algorithms MH - Athletic Performance/physiology MH - *Fatigue/diagnosis MH - Random Forest PMC - PMC13065852 OTO - NOTNLM OT - Fatigue OT - Machine learning OT - Racket OT - Sensors OT - Table tennis COIS- Competing interests: The authors declare no competing interests. Informed consent: The authors confirm that all methods presented in this paper were conducted in accordance with the Declaration of Helsinki and its latest amendments. The local ethics committee for non-interventional research at Nantes University (n degrees IRB: IORG0011023) has approved the presented procedures. The authors confirm that informed consent was obtained from all subjects and/or their legal representative. Consent for publication: The authors declare that informed consent was obtained from all subjects and/or their legal representative for the publication of personal information/images in open-access online scientific publications, and that data collection was carried out only after obtaining their informed consent. EDAT- 2026/03/04 01:17 MHDA- 2026/04/10 00:33 PMCR- 2026/03/03 CRDT- 2026/03/03 23:17 PHST- 2025/09/18 00:00 [received] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/04/10 00:33 [medline] PHST- 2026/03/04 01:17 [pubmed] PHST- 2026/03/03 23:17 [entrez] PHST- 2026/03/03 00:00 [pmc-release] AID - 10.1038/s41598-026-40324-w [pii] AID - 40324 [pii] AID - 10.1038/s41598-026-40324-w [doi] PST - epublish SO - Sci Rep. 2026 Mar 3;16(1):11812. doi: 10.1038/s41598-026-40324-w. PMID- 41775362 OWN - NLM STAT- MEDLINE DCOM- 20260804 LR - 20260804 IS - 0004-0614 (Print) IS - 0004-0614 (Linking) VI - 79 IP - 1 DP - 2026 Jan TI - Establishment and Validation of a Nomogram Model for Predicting the Risk of Postpartum Stress Urinary Incontinence in Women during the Perinatal Period. PG - 134-144 LID - 10.56434/j.arch.esp.urol.20267901.16 [doi] AB - OBJECTIVE: This study aims to analyse factors influencing maternal postpartum stress urinary incontinence (SUI) and construct a prediction model using a nomogram. METHODS: A retrospective analysis of clinical data was conducted on 500 women who delivered at our hospital between June 2021 and June 2024, of whom 147 developed postpartum SUI. The participants were randomly assigned to the modelling (n = 354) or validation groups (n = 146) in a 7:3 ratio. The modelling group was further subdivided on the basis of postpartum SUI occurrence: SUI (n = 106) and non-SUI groups (n = 248). Relevant factors were identified through logistic regression analysis, and a nomogram was constructed using R software. The nomogram was evaluated through receiver operating characteristic, calibration and decision curves. RESULTS: Significant differences existed between the SUI and non-SUI groups in maternal educational attainment, newborn weight, current address, natural birth and gestation period (p < 0.05). Educational attainment (junior high school and below), increase in newborn weight, rural residence, natural birth and parity (>/= 2) were identified as risk factors for postpartum SUI (p < 0.05). The nomogram showed good predictive performance with area under the curve (AUC) values of 0.778 and 0.754 for the modelling and validation groups, respectively (p < 0.05). CONCLUSIONS: Maternal educational attainment, newborn weight, current address, natural birth and gestation period are risk factors for postpartum SUI. Based on these factors, the proposed nomogram model is a potentially reliable tool for predicting postpartum SUI risk. CI - (c) 2026 The Author(s). FAU - Yu, Shuwen AU - Yu S AD - Department of Women's Health Care, Nantong Maternity and Child Health Care Hospital, Affiliated Maternity and Child Health Care Hospital of Nantong University, 226000 Nantong, Jiangsu, China. FAU - Yin, Fengling AU - Yin F AD - Department of Obstetrics and Gynecology, Xuzhou Central Hospital, 221000 Xuzhou, Jiangsu, China. FAU - Fan, Yihui AU - Fan Y AD - Department of Thoracic Surgery, Affiliated Cancer Hospital of Nantong University, 226000 Nantong, Jiangsu, China. FAU - Qu, Qiuchan AU - Qu Q AD - Department of Women's Health Care, Nantong Maternity and Child Health Care Hospital, Affiliated Maternity and Child Health Care Hospital of Nantong University, 226000 Nantong, Jiangsu, China. LA - eng PT - Journal Article PT - Validation Study PL - Spain TA - Arch Esp Urol JT - Archivos espanoles de urologia JID - 0064757 SB - IM MH - *Urinary Incontinence, Stress/epidemiology MH - Postpartum Period MH - Nomograms MH - Humans MH - Female MH - Pregnancy MH - *Puerperal Disorders/epidemiology MH - Retrospective Studies MH - Random Allocation MH - Risk Factors MH - Educational Status MH - Birth Weight MH - Infant, Newborn MH - Parity MH - Maternal Age MH - Young Adult MH - Adult OTO - NOTNLM OT - maternity OT - nomogram OT - postpartum stress incontinence COIS- The authors declare no conflict of interest. EDAT- 2026/03/04 01:17 MHDA- 2026/03/07 16:16 CRDT- 2026/03/03 20:12 PHST- 2026/03/07 16:16 [medline] PHST- 2026/03/04 01:17 [pubmed] PHST- 2026/03/03 20:12 [entrez] AID - 1770000700526-580408088 [pii] AID - 10.56434/j.arch.esp.urol.20267901.16 [doi] PST - ppublish SO - Arch Esp Urol. 2026 Jan;79(1):134-144. doi: 10.56434/j.arch.esp.urol.20267901.16. PMID- 41774440 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 9 IP - 3 DP - 2026 Mar 2 TI - Ultraprocessed Food Consumption and Behavioral Outcomes in Canadian Children. PG - e260434 LID - 10.1001/jamanetworkopen.2026.0434 [doi] LID - e260434 AB - IMPORTANCE: Ultraprocessed foods (UPF) contribute to nearly half of energy intake among preschool-aged children in Canada, yet their impact on behavioral and emotional functioning remains underexplored. OBJECTIVE: To examine the associations between UPF intake at age 3 years and behavioral outcomes at age 5 years. DESIGN, SETTING, AND PARTICIPANTS: This cohort study included children with dietary and behavioral data from September 2011 to April 2018 in the CHILD Cohort Study, a prospective Canadian pregnancy cohort. Data analysis was done between February to July 2025. EXPOSURE: UPF intake at age 3 years was assessed by a 112-item food frequency questionnaire and categorized using the NOVA system. MAIN OUTCOMES AND MEASURES: Behavior was measured using the validated Child Behavior Checklist (CBCL; range 0-100; higher scores indicating more adverse symptoms). UPF intake measured as a continuous percentage of energy was examined using multivariable-adjusted linear regression models accounting for maternal diet, birth factors, infant feeding, and sociodemographic and early-childhood characteristics. A multivariable-adjusted substitution model estimated the association of statistically replacing 10% energy from UPF with minimally processed foods (MPF) among all children. RESULTS: Among 2077 participants, 1092 (52.6%) were male; 1376 children (66.2%) were White, 480 children (23.1%) were multiracial, and 221 children (10.7%) were identified as another ethnic group. At age 3 years, UPF contributed a mean (SD) of 45.5% (11.6%) of total energy intake. At age 5 years, the mean (SD) CBCL scores were 44.6 (9.1) for internalizing, 39.6 (9.4) for externalizing, and 41.2 (9.0) for total behavior. Each 10% increase in energy from UPF was associated with higher CBCL internalizing (beta = 0.81 [95% CI, 0.43 to 1.19]), externalizing (beta = 0.47 [95% CI, 0.08 to 0.87]), and total (beta = 0.64 [95% CI, 0.27 to 1.01]) scores. Substitution of 10% energy from UPF with MPF was associated with lower internalizing (beta = -0.91 [95% CI, -1.33 to -0.49]), externalizing (beta = -0.49 [95% CI, -0.93 to -0.06]), and total (beta = -0.70 [95% CI, -1.12 to -0.29]) scores. CONCLUSIONS AND RELEVANCE: In this cohort study of preschoolers in Canada, higher UPF intake was associated with adverse behavioral and emotional symptoms by age 5 years. These findings suggest that replacing UPF with MPF during the preschool years may support healthier behavioral development, with potential benefits for long-term mental health. These findings also support ongoing policy actions that promote MPF and underscore the need for early-life dietary interventions. FAU - Kavanagh, Meaghan E AU - Kavanagh ME AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. FAU - Chen, Zheng Hao AU - Chen ZH AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. FAU - Tamana, Sukhpreet K AU - Tamana SK AD - Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Moraes, Theo J AU - Moraes TJ AD - Department of Paediatrics, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. AD - Department of Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. FAU - Simons, Elinor AU - Simons E AD - Section of Allergy and Clinical Immunology, Department of Pediatrics and Child Health, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. FAU - Turvey, Stuart E AU - Turvey SE AD - Division of Allergy and Immunology, Department of Pediatrics, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Subbarao, Padmaja AU - Subbarao P AD - Department of Translational Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada. AD - Department of Physiology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. AD - Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. FAU - Mandhane, Piushkumar J AU - Mandhane PJ AD - Department of Pediatrics, Faculty of Medicine & Dentistry, University of Alberta, Edmonton, Alberta, Canada. AD - Faculty of Medicine, University College Sedaya International, Kuala Lumpur, Malaysia. FAU - Miliku, Kozeta AU - Miliku K AD - Department of Nutritional Sciences, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. AD - Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260302 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 SB - IM MH - Humans MH - Female MH - Child, Preschool MH - Food, Processed MH - Canada/epidemiology MH - Male MH - *Child Behavior/psychology MH - Prospective Studies MH - Energy Intake MH - Feeding Behavior MH - Cohort Studies MH - *Diet PMC - PMC12958080 COIS- Conflict of Interest Disclosures: Dr Moraes reported receiving grants from the Canadian Institute for Health Research (CIHR), Cystic Fibrosis Canada, and the Physicians' Services Incorporated Foundation outside the submitted work. Dr Simons reported grants from CIHR and serving on the faculties of Children's Hospital Research Institute of Manitoba and University of Manitoba outside the submitted work. Dr Mandhane reported nonfinancial support from Fairly AI and grants from CIHR and Women's and Children's Health Research Institute outside the submitted work. Dr Miliku reported receiving grants from CIHR and Heart and Stroke outside the submitted work. No other disclosures were reported. EDAT- 2026/03/03 12:32 MHDA- 2026/03/06 19:43 PMCR- 2026/03/03 CRDT- 2026/03/03 11:32 PHST- 2026/03/06 19:43 [medline] PHST- 2026/03/03 12:32 [pubmed] PHST- 2026/03/03 11:32 [entrez] PHST- 2026/03/03 00:00 [pmc-release] AID - 2845768 [pii] AID - zoi260032 [pii] AID - 10.1001/jamanetworkopen.2026.0434 [doi] PST - epublish SO - JAMA Netw Open. 2026 Mar 2;9(3):e260434. doi: 10.1001/jamanetworkopen.2026.0434. PMID- 41774199 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260628 IS - 1432-1246 (Electronic) IS - 0340-0131 (Linking) VI - 99 IP - 2 DP - 2026 Mar 3 TI - DNA methylation as an epigenetic marker of children's exposure to traffic-related air pollution in the Klang Valley, Malaysia. LID - 16 [pii] LID - 10.1007/s00420-026-02204-8 [doi] AB - PURPOSE: Traffic-related air pollution (TRAP) poses significant health risks to children. While adverse outcomes have been reported, the biological mechanisms underlying these effects remain unclear. This study investigates the association between TRAP exposure and DNA methylation (DNAm) changes in TNFalpha and CYP1A1 genes as potential epigenetic markers among school children in Malaysia. METHODS: A cross-sectional comparative study was conducted involving 248 children aged 7-11 years from high-traffic (HT) and low-traffic (LT) areas in the Klang Valley. Environmental monitoring was performed at both schools and residences to measure levels of PM10, PM2.5, PM1, NO2, SO2, O3, CO, total volatile organic compounds (TVOC), and black carbon (BC). Dietary intake and other potential confounders were assessed via validated questionnaires. Saliva samples were collected and analyzed for DNAm status using methylation-specific polymerase chain reaction (MS-PCR) targeting TNFalpha and CYP1A1 genes. RESULTS: Pollutant levels were significantly elevated in HT schools (p < 0.001), whereas LT schools recorded higher CO2 concentrations. Children in HT areas had significantly higher methylation in TNFalpha (54.0% vs. 37.1%; OR = 2.0, p = 0.007) and CYP1A1 (51.6% vs. 37.9%; OR = 1.7, p = 0.030). TNFalpha methylation was associated with NO2 exposure (OR = 3.0, 95% CI 0.88-1.95, p = 0.036), while CYP1A1 methylation was linked to BC exposure (OR = 2.0, 95% CI 1.02-2.03, p = 0.019). No significant association was observed for residential TRAP exposure. CONCLUSION: TRAP exposure in school environments is associated with gene-specific epigenetic modifications in children, suggesting potential utility of DNAm as an early biomarker and reinforcing the need for targeted mitigation strategies. FAU - Jalaludin, Juliana AU - Jalaludin J AUID- ORCID: 0000-0002-7910-6945 AD - Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. AD - Emerging Pollutant, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. FAU - Suhaimi, Nur Faseeha AU - Suhaimi NF AUID- ORCID: 0000-0002-5923-8713 AD - Department of Environmental and Occupational Health, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. nurfaseeha@upm.edu.my. FAU - Abubakar, Suhaili AU - Abubakar S AUID- ORCID: 0000-0002-2217-4509 AD - Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400, Serdang, Selangor, Malaysia. LA - eng GR - FRGS/1/2019/SKK06/UPM/02/6/Ministry of Higher Education Malaysia/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260303 PL - Germany TA - Int Arch Occup Environ Health JT - International archives of occupational and environmental health JID - 7512134 RN - 0 (Tumor Necrosis Factor-alpha) RN - EC 1.14.14.1 (Cytochrome P-450 CYP1A1) RN - 0 (Air Pollutants) RN - 0 (Biomarkers) RN - EC 1.14.14.1 (CYP1A1 protein, human) RN - 0 (Vehicle Emissions) SB - IM MH - Humans MH - *DNA Methylation MH - Malaysia MH - Child MH - Cross-Sectional Studies MH - Female MH - Tumor Necrosis Factor-alpha/genetics MH - *Environmental Exposure/analysis/adverse effects MH - *Traffic-Related Pollution/analysis/adverse effects MH - Male MH - Cytochrome P-450 CYP1A1/genetics MH - *Air Pollutants/analysis/adverse effects MH - Environmental Monitoring MH - Biomarkers MH - *Vehicle Emissions/analysis MH - Epigenesis, Genetic MH - Saliva/chemistry MH - *Air Pollution/analysis/adverse effects OTO - NOTNLM OT - Black carbon OT - Nitrogen dioxide OT - School children OT - School environments OT - Traffic COIS- Declarations. Conflict of interest: The authors have no conflict of interest. EDAT- 2026/03/03 12:32 MHDA- 2026/06/27 12:38 CRDT- 2026/03/03 11:17 PHST- 2025/10/02 00:00 [received] PHST- 2026/01/23 00:00 [accepted] PHST- 2026/06/27 12:38 [medline] PHST- 2026/03/03 12:32 [pubmed] PHST- 2026/03/03 11:17 [entrez] AID - 10.1007/s00420-026-02204-8 [pii] AID - 10.1007/s00420-026-02204-8 [doi] PST - epublish SO - Int Arch Occup Environ Health. 2026 Mar 3;99(2):16. doi: 10.1007/s00420-026-02204-8. PMID- 41773842 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20260923 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 37 IP - 3-4 DP - 2026 Mar-Apr 01 TI - Defining Prominauris in the Pediatric Population: A Systematic Review. PG - 668-672 LID - 10.1097/SCS.0000000000012242 [doi] AB - BACKGROUND: Prominauris, or protruding ears, is a common pediatric craniofacial deformity often associated with psychosocial distress. Although otoplasty can address these concerns, there is no standardized classification system to guide diagnosis or surgical decision-making. Existing definitions vary widely and inconsistently account for anatomic and developmental factors such as age and sex. This study aims to systematically review prominauris classification systems and propose a more objective, practical framework. METHODS: A systematic review was conducted using MEDLINE, Embase, CINAHL, and Cochrane Trials to identify studies defining or classifying prominauris in individuals under 18 years old. Two independent reviewers screened articles, extracted data on classification features and methods, and performed a critical appraisal using 6 predefined criteria, including clarity, generalizability, objectivity, reproducibility, and demographic considerations. RESULTS: Of the 2049 articles screened, 15 met the inclusion criteria. Classifications varied considerably: 47% used subjective assessments, 40% used physical measurements, and 13% used digital tools. Most incorporated multiple auricular features, with inconsistent use of anatomic landmarks and measurement thresholds. Only one system accounted for age, and one for sex; no classification integrated both. None met all 6appraisal criteria. On the basis of these findings, the authors propose a novel 2-step classification system using mastoid-helical distance at the tragal level, with age-specific and sex-specific thresholds derived from a large pediatric anthropometric data set. CONCLUSIONS: Existing prominauris classification systems are inconsistent and lack demographic variability. The authors' proposed system offers a simple, reproducible, objective approach that accounts for age and sex, facilitating more consistent diagnosis and surgical decision-making. Validation studies are warranted. CI - Copyright (c) 2025 by Mutaz B. Habal, MD. FAU - Covone, Jason AU - Covone J AUID- ORCID: 0009-0004-0802-0310 AD - Division of Plastic Surgery, Universite de Montreal. FAU - Bouhadana, Gabriel C AU - Bouhadana GC AD - Division of Plastic Surgery, Universite de Montreal. FAU - Cugno, Sabrina AU - Cugno S AD - Division of Plastic Surgery, Universite de Montreal. AD - Division of Plastic Surgery, McGill University, Montreal, QC, Canada. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20260225 PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 SB - IM MH - Humans MH - Child MH - *Ear, External/abnormalities/surgery MH - Adolescent OTO - NOTNLM OT - Congenital adnexa OT - craniofacial overgrowth OT - evidence based care OT - prominauris OT - prominent ear OT - recontruction of head and neck OT - systematic review COIS- The authors report no conflicts of interest. EDAT- 2026/03/03 12:31 MHDA- 2026/03/07 18:38 CRDT- 2026/03/03 08:57 PHST- 2025/09/29 00:00 [received] PHST- 2025/10/12 00:00 [accepted] PHST- 2026/03/07 18:38 [medline] PHST- 2026/03/03 12:31 [pubmed] PHST- 2026/03/03 08:57 [entrez] AID - 00001665-202603000-00059 [pii] AID - 10.1097/SCS.0000000000012242 [doi] PST - ppublish SO - J Craniofac Surg. 2026 Mar-Apr 01;37(3-4):668-672. doi: 10.1097/SCS.0000000000012242. Epub 2026 Feb 25. PMID- 41773697 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260901 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Feb 27 TI - Feasibility of Vigorous Extended Reality Tele-Exergaming for Cardiometabolic Health in Youth With Mobility Disabilities: Protocol for a Case Series Study. PG - e85246 LID - 10.2196/85246 [doi] LID - e85246 AB - BACKGROUND: Young people with mobility disabilities have limited options to maintain their cardiometabolic health and cardiorespiratory fitness. Active video gaming using extended reality head-mounted displays is becoming increasingly common for promoting serious exergaming. However, there is a need to identify dosing protocols that can potentially lead to meaningful improvements in cardiometabolic health and cardiorespiratory fitness. OBJECTIVE: This feasibility study aims to explore potential benefits of vigorous-intensity extended reality exergaming, conducted at home with telemonitoring for body composition and cardiometabolic health, in 4 young people with cerebral palsy and overweight or obesity. The secondary aim is to assess the effects of the program on cardiorespiratory fitness. The tertiary aim is to describe the safety and acceptability of the intervention. METHODS: This case study is a phase 1 feasibility trial with a pretest-to-posttest design including 4 participants. Young people with cerebral palsy and overweight or obesity (aged 13-24 years) will be purposively selected to participate based on 2 mobility categories (ambulatory: n=2; nonambulatory: n=2). The intervention prescription will include 240 minutes per week of vigorous-intensity exercise at home for a total of 6 weeks, with telemonitoring of exercise data that will be supplemented with weekly coaching calls. Participants will exercise using a head-mounted display to control an immersive exergame. Caregivers will agree to manage a play schedule and assess their children's safety during play. Body composition will be measured using dual-energy x-ray absorptiometry at the pre- and postintervention time points (weeks 0 and 7, respectively). Blood-related health (fasting insulin, lipids, high-sensitivity C-reactive protein, and glycated hemoglobin) will be measured via a blood spot test, and blood pressure will be measured via a sphygmomanometer. Cardiorespiratory fitness (peak oxygen consumption) will be measured using a portable metabolic cart (COSMED K5) during a graded exercise test on an arm ergometer at the pre- and postintervention time points. Quantitative process metrics and qualitative feedback will be used to assess feasibility. Changes in outcomes over time will be descriptively analyzed. RESULTS: Recruitment began in October 2025. All data are anticipated to be collected by December 2025. Full results are anticipated to be analyzed and submitted for publication by April 2026. CONCLUSIONS: This feasibility study tests an accessible and intensive program, which leverages high-intensity exercise gaming with telehealth procedures for children with cerebral palsy. Study findings will inform a pilot efficacy trial to improve cardiometabolic health and fitness among young people with mobility disabilities. CI - (c) Byron Lai, Maggie Logan, Raven Young, Ashley Wright, Jordyn Terrell, Larsen Bright, Drew Davis, Christen J Mendonca. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Lai, Byron AU - Lai B AUID- ORCID: 0000-0002-5464-4720 AD - Division of Pediatric Rehabilitation Medicine, Department of Pediatrics, University of Alabama at Birmingham, 1720 2nd Ave South, Birmingham, AL, 35294-1801, United States, 1 205-934-4011. FAU - Logan, Maggie AU - Logan M AUID- ORCID: 0009-0001-1538-5834 AD - Division of Pediatric Rehabilitation Medicine, Department of Pediatrics, University of Alabama at Birmingham, 1720 2nd Ave South, Birmingham, AL, 35294-1801, United States, 1 205-934-4011. AD - Department of Occupational Therapy, University of Alabama at Birmingham, Birmingham, AL, United States. FAU - Young, Raven AU - Young R AUID- ORCID: 0000-0003-2879-3236 AD - Division of Pediatric Rehabilitation Medicine, Department of Pediatrics, University of Alabama at Birmingham, 1720 2nd Ave South, Birmingham, AL, 35294-1801, United States, 1 205-934-4011. FAU - Wright, Ashley AU - Wright A AUID- ORCID: 0009-0000-5466-0432 AD - Division of Pediatric Rehabilitation Medicine, Department of Pediatrics, University of Alabama at Birmingham, 1720 2nd Ave South, Birmingham, AL, 35294-1801, United States, 1 205-934-4011. FAU - Terrell, Jordyn AU - Terrell J AUID- ORCID: 0009-0001-4578-9127 AD - Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL, United States. FAU - Bright, Larsen AU - Bright L AUID- ORCID: 0009-0001-9167-8663 AD - Division of Pediatric Rehabilitation Medicine, Department of Pediatrics, University of Alabama at Birmingham, 1720 2nd Ave South, Birmingham, AL, 35294-1801, United States, 1 205-934-4011. FAU - Davis, Drew AU - Davis D AUID- ORCID: 0000-0003-1860-7452 AD - Division of Pediatric Rehabilitation Medicine, Department of Pediatrics, University of Alabama at Birmingham, 1720 2nd Ave South, Birmingham, AL, 35294-1801, United States, 1 205-934-4011. FAU - Mendonca, Christen J AU - Mendonca CJ AUID- ORCID: 0000-0002-9116-2536 AD - Research Collaborative, School of Health Professions, University of Alabama at Birmingham, Birmingham, AL, United States. LA - eng SI - ClinicalTrials.gov/NCT07155213 PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260227 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Adolescent MH - Feasibility Studies MH - Male MH - Female MH - *Exergaming MH - Young Adult MH - *Cardiorespiratory Fitness/physiology MH - *Cerebral Palsy/complications MH - *Mobility Limitation MH - *Video Games MH - *Exercise Therapy/methods MH - Obesity/therapy MH - Overweight/therapy PMC - PMC12954695 OTO - NOTNLM OT - active video gaming OT - disability OT - exercise OT - exergaming OT - extended reality OT - physical activity COIS- Conflicts of Interest: None declared. EDAT- 2026/03/03 12:32 MHDA- 2026/03/07 06:40 PMCR- 2026/02/27 CRDT- 2026/03/03 07:45 PHST- 2025/10/03 00:00 [received] PHST- 2025/12/03 00:00 [revised] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/03/07 06:40 [medline] PHST- 2026/03/03 12:32 [pubmed] PHST- 2026/03/03 07:45 [entrez] PHST- 2026/02/27 00:00 [pmc-release] AID - v15i1e85246 [pii] AID - 85246 [pii] AID - 10.2196/85246 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Feb 27;15:e85246. doi: 10.2196/85246. PMID- 41773480 OWN - NLM STAT- MEDLINE DCOM- 20260608 LR - 20260608 IS - 1099-0968 (Electronic) IS - 1072-4133 (Linking) VI - 34 IP - 4 DP - 2026 Jul TI - Validation of DSM-5 Severity Specifiers for Bulimia Nervosa and Binge Eating Disorder and an Alternative Specifier for Binge Eating Disorder in a Korean Cohort. PG - 1075-1088 LID - 10.1002/erv.70095 [doi] AB - OBJECTIVE: We examined the clinical validity of DSM-5 severity specifiers for bulimia nervosa (BN) and binge eating disorder (BED) in Korean outpatients. METHOD: Seven hundred ninety-nine outpatients with BN (n = 668; mean age = 23.7 years; 95% female; mean BMI = 20.54 kg/m(2)) or BED (n = 131; mean age = 26.1 years; 89% female; mean BMI = 25.07 kg/m(2)) were recruited from an eating disorders clinic. For BN, we assessed the validity of severity specifiers based on purging-type behaviours and overall compensatory behaviours. For BED, we examined the validity of the current severity specifier and an alternative specifier with an adjusted threshold based on the frequency distribution. RESULTS: For BN, severity based on purging-type behaviours differentiated BMI and self-injury, whereas severity based on overall compensatory behaviours differentiated the level of weight suppression as well as eating-related and general psychopathology. In both classifications, increasing severity was linked to a greater likelihood of self-injury. For BED, 90% of patients were classified as mild-to-moderate using the current specifier. The adjusted index correlated more strongly with EDE-Q shape concerns and global scores than the current index. CONCLUSIONS: The BN specifier differentiated clinical variables across severity groups. The adjusted BED specifier may better differentiate severity in the Korean population than the DSM-5 specifier, suggesting the potential benefit of cultural adjustments. CI - (c) 2026 The Author(s). European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd. FAU - An, Zhen AU - An Z AUID- ORCID: 0000-0002-6233-9013 AD - Institute of Eating Disorders and Mental Health, Inje University, Seoul, South Korea. AD - Melbourne School of Psychological Sciences, University of Melbourne, Melbourne, Victoria, Australia. FAU - Kim, Youl-Ri AU - Kim YR AUID- ORCID: 0000-0002-5538-7180 AD - Institute of Eating Disorders and Mental Health, Inje University, Seoul, South Korea. AD - Department of Psychiatry, Ilsan Paik Hospital, Inje University, Goyang, South Korea. AD - Institute for Gender Research, Seoul National University, Seoul, South Korea. FAU - Treasure, Janet AU - Treasure J AUID- ORCID: 0000-0003-0871-4596 AD - Centre for Research in Eating and Weight Disorders (CREW), Department of Psychological Medicine, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK. LA - eng GR - 2021R1A2C2009668/National Research Foundation of Korea/ PT - Journal Article PT - Validation Study DEP - 20260303 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 SB - IM MH - Humans MH - Female MH - *Bulimia Nervosa/diagnosis/classification/psychology MH - *Binge-Eating Disorder/diagnosis/classification/psychology MH - *Diagnostic and Statistical Manual of Mental Disorders MH - Adult MH - Republic of Korea MH - Severity of Illness Index MH - Young Adult MH - Reproducibility of Results MH - Cohort Studies MH - Body Mass Index MH - Adolescent OTO - NOTNLM OT - binge eating disorder OT - bulimia nervosa OT - diagnostic and statistical manual of mental disorders, fifth edition (DSM-5) OT - severity specifier EDAT- 2026/03/03 06:30 MHDA- 2026/06/08 19:41 CRDT- 2026/03/03 05:52 PHST- 2025/12/11 00:00 [revised] PHST- 2025/03/24 00:00 [received] PHST- 2026/02/20 00:00 [accepted] PHST- 2026/06/08 19:41 [medline] PHST- 2026/03/03 06:30 [pubmed] PHST- 2026/03/03 05:52 [entrez] AID - 10.1002/erv.70095 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2026 Jul;34(4):1075-1088. doi: 10.1002/erv.70095. Epub 2026 Mar 3. PMID- 41773356 OWN - NLM STAT- MEDLINE DCOM- 20260306 LR - 20260513 IS - 1972-6007 (Electronic) IS - 0009-9074 (Linking) VI - 177 IP - 2 DP - 2026 Mar-Apr TI - Effectiveness of peripartum video-based health education in improving maternal breast feeding self-efficacy and breastfeeding behaviour among Primigravida women through the COVID-19 Pandemic: a randomized controlled trial. PG - 195-203 LID - 10.7417/CT.2026.1995 [doi] AB - BACKGROUND: Effective antenatal breastfeeding education is necessary to promote breastfeeding self-efficacy, and to ensure exclusive breast-feeding for six months. This study assessed the effect of video education on breast feeding technique on primigravida women's breast feeding self-confidence and her feeding behavior in early infancy. METHODS: We conducted a facility based two-arm randomized controlled trial in a public tertiary maternity hospital. Primi gravida women were assigned by simple random sampling to intervention group (IG) and control group (CG). Both groups received group lessons with picture charts about newborn care as per hospital policy. Women in the IG were educated by principal investigator (PI) with a culturally adapted and linguistically validated Kannada-language video to demonstrate breastfeeding techniques. The Breast-feeding counsellor measured mothers' breastfeeding confidence before and after education using Breast feeding self-efficacy scale- short form (BSES-SF). She also checked breast-feeding technique within 48hours after birth using the Bristol Breastfeeding assessment tool (BBAT). The PI telephonically called the mothers at 2, 4, and 6 months to ask about her breastfeeding behavior. RESULTS: One hundred twenty-eight antenatal women were randomised with 1:1 allocation into the IG and CG. Baseline demographic characteristics among the two groups were similar. Maternal breast feeding self confidence using BSES-SF showed improvement in the IG (p-value 0.031). Significant improvement was noted in the technique of breastfeeding in IG compared to the CG (7.9 vs 7.3) (p-value <0.001) by the BBAT. 66.7% of subjects in the IG achieved a score of 8 compared to 27.6% of subjects in CG. (p-value 0.066). At the end of 6 months, exclusive breastfeeding rates were significantly higher in IG (93.8%) compared to the CG (59.4%) (p-value < 0.001). CONCLUSION: Women accepted education on breastfeeding technique by a video uploaded on their mobile phones. Video educational intervention significantly improved maternal self-confidence and exclusive breastfeeding duration. FAU - G, Pooja AU - G P AD - Department of Paediatrics, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal. India. FAU - Kamath, Nutan AU - Kamath N AD - Department of Paediatrics, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India. FAU - Mithra, Prasanna AU - Mithra P AD - Department of Community Medicine, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India. FAU - Rao, Suchetha S AU - Rao SS AD - Department of Paediatrics, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - Italy TA - Clin Ter JT - La Clinica terapeutica JID - 0372604 SB - IM MH - Adult MH - Female MH - Humans MH - Infant, Newborn MH - Pregnancy MH - *Breast Feeding/psychology/statistics & numerical data MH - *COVID-19/epidemiology MH - Gravidity MH - *Health Education/methods MH - Pandemics MH - Peripartum Period MH - *Self Efficacy MH - *Video Recording OTO - NOTNLM OT - antenatal education. OT - breastfeeding con fi dence OT - infant feeding pattern OT - mhealth OT - video assisted education EDAT- 2026/03/03 06:30 MHDA- 2026/03/06 13:47 CRDT- 2026/03/03 04:43 PHST- 2026/03/06 13:47 [medline] PHST- 2026/03/03 06:30 [pubmed] PHST- 2026/03/03 04:43 [entrez] AID - 10.7417/CT.2026.1995 [doi] PST - ppublish SO - Clin Ter. 2026 Mar-Apr;177(2):195-203. doi: 10.7417/CT.2026.1995. PMID- 41773188 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1178-2048 (Electronic) IS - 1176-6344 (Print) IS - 1176-6344 (Linking) VI - 22 DP - 2026 TI - Role of Cardiopulmonary Exercise Testing in the Monitoring of Cardiovascular Risk Factors in Athletes - State-of-the-Art Review. PG - 575333 LID - 10.2147/VHRM.S575333 [doi] LID - 575333 AB - Although physical activity has beneficial effects for health, athletes also suffer from cardiovascular diseases (CVD). The type and prevalence of CVD in athletes depend on their age, but typically include hypertrophic cardiomyopathy, arrhythmias, and valve diseases. In pediatric athletes <18 years old, congenital heart diseases (CHD) are prevalent, while in master athletes >35 years old, coronary artery disease (CAD) is the most common. Cardiopulmonary exercise testing (CPET) is a gold standard to evaluate cardiorespiratory fitness (CRF). Although CRF is most often identified as peak oxygen uptake ([Formula: see text]O(2peak)), CPET provides a multidimensional assessment through several other cardiorespiratory variables. CVD aggravates CRF and reduces [Formula: see text]O(2peak). While there is no universal pattern of alteration in the remaining CPET parameters, the specific deviations depend on the type of CVD. Therefore, precise monitoring of changes in CPET scores is crucial for risk stratification, adjusting exercise intensity, enabling safe sports participation, and authorizing return to sport after treatment. Among athletes, CPET plays a pivotal role across all fields. Therefore, this review aimed to evaluate the value of CPET in 1) identification of risk factors of CVD among athletes, considered as changes in CRF, 2) monitoring of treatment, and 3) making shared decisions on returning to sport. A special focus was placed on the needs of emerging age groups - pediatric and master athletes. Additionally, evidence gaps and directions for future research were discussed. CI - (c) 2026 Kasiak. FAU - Kasiak, Przemyslaw AU - Kasiak P AUID- ORCID: 0000-0002-0303-6135 AD - 3rd Department of Internal Medicine and Cardiology, Medical University of Warsaw, Warsaw, Poland. LA - eng PT - Journal Article PT - Review DEP - 20260225 PL - New Zealand TA - Vasc Health Risk Manag JT - Vascular health and risk management JID - 101273479 SB - IM MH - Humans MH - *Cardiorespiratory Fitness MH - *Exercise Test MH - Heart Disease Risk Factors MH - *Athletes MH - *Cardiovascular Diseases/physiopathology/diagnosis/therapy/epidemiology MH - Predictive Value of Tests MH - Risk Assessment MH - *Exercise Tolerance MH - Prognosis MH - Child MH - Adolescent MH - Oxygen Consumption MH - Risk Factors MH - Age Factors MH - Return to Sport MH - Male PMC - PMC12950176 OTO - NOTNLM OT - CPET OT - athlete OT - cardiopulmonary exercise testing OT - cardiovascular disease OT - risk factor COIS- The author reports no conflicts of interest in this work. EDAT- 2026/03/03 06:30 MHDA- 2026/03/06 13:45 PMCR- 2026/02/25 CRDT- 2026/03/03 03:58 PHST- 2025/10/19 00:00 [received] PHST- 2026/02/08 00:00 [accepted] PHST- 2026/03/06 13:45 [medline] PHST- 2026/03/03 06:30 [pubmed] PHST- 2026/03/03 03:58 [entrez] PHST- 2026/02/25 00:00 [pmc-release] AID - 575333 [pii] AID - 10.2147/VHRM.S575333 [doi] PST - epublish SO - Vasc Health Risk Manag. 2026 Feb 25;22:575333. doi: 10.2147/VHRM.S575333. eCollection 2026. PMID- 41772632 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1749-8090 (Electronic) IS - 1749-8090 (Linking) VI - 21 IP - 1 DP - 2026 Mar 2 TI - Preoperative decision tree model for predicting pulmonary valve-sparing repair in humanitarian pediatric tetralogy of fallot patients. LID - 10.1186/s13019-026-03882-8 [doi] LID - 161 AB - BACKGROUND: Pulmonary valve-sparing repair in Tetralogy of Fallot is associated with better long-term outcomes, but its feasibility remains uncertain in pediatric humanitarian patients, who often present late, with complex anatomy and comorbidities. OBJECTIVE: To develop a simple and interpretable decision tree model to predict the likelihood of pulmonary valve-sparing repair based on preoperative data in a humanitarian pediatric cohort. METHODS: A post-hoc classification and regression tree analysis was conducted on 115 pediatric humanitarian patients with Tetralogy of Fallot who underwent surgical correction at our center, between 2019 and 2023. Predictor variables included demographic, anthropometric, and anatomical parameters. RESULTS: The model achieved an overall accuracy of 80.0%, with a sensitivity of 88.2% and specificity of 56.7%. The pulmonary valve annulus diameter (> 0.855 cm) was the primary discriminator for pulmonary valve-sparing repair. CONCLUSION: A simple decision tree model using preoperative anatomical variables may support surgical planning in humanitarian contexts. Its interpretability and high sensitivity suggest potential value as a preoperative triage and planning aid. FAU - Mendes, Vitor AU - Mendes V AUID- ORCID: 0000-0001-6369-5784 AD - Division of Cardiovascular Surgery, Department of Surgery, Geneva University Hospitals (HUG), Geneva, 1211, Switzerland. VitorJose.Nogueira@hcuge.ch. AD - Global Health and Tropical Medicine, Institute of Hygiene and Tropical Medicine, NOVA University of Lisbon (IHMT-UNL), Lisbon, Portugal. VitorJose.Nogueira@hcuge.ch. FAU - Mouloudi, Abdelkhalek AU - Mouloudi A AD - Division of Cardiovascular Surgery, Department of Surgery, Geneva University Hospitals (HUG), Geneva, 1211, Switzerland. FAU - Jolou, Jalal AU - Jolou J AD - Division of Cardiovascular Surgery, Department of Surgery, Geneva University Hospitals (HUG), Geneva, 1211, Switzerland. FAU - Nalecz, Tomasz AU - Nalecz T AD - Division of Cardiovascular Surgery, Department of Surgery, Geneva University Hospitals (HUG), Geneva, 1211, Switzerland. FAU - Abecasis, Ana AU - Abecasis A AD - Global Health and Tropical Medicine, Institute of Hygiene and Tropical Medicine, NOVA University of Lisbon (IHMT-UNL), Lisbon, Portugal. FAU - Pereira, Telmo AU - Pereira T AD - H&TRC - Health & Technology Research Center, Coimbra Health School, Polytechnic University of Coimbra, Coimbra, Portugal. FAU - Sologashvili, Tornike AU - Sologashvili T AD - Division of Cardiovascular Surgery, Department of Surgery, Geneva University Hospitals (HUG), Geneva, 1211, Switzerland. LA - eng PT - Journal Article DEP - 20260302 PL - England TA - J Cardiothorac Surg JT - Journal of cardiothoracic surgery JID - 101265113 SB - IM MH - Humans MH - *Tetralogy of Fallot/surgery MH - *Decision Trees MH - Female MH - Male MH - *Pulmonary Valve/surgery MH - Child MH - *Cardiac Surgical Procedures/methods MH - Child, Preschool MH - Infant MH - Retrospective Studies PMC - PMC13059338 OTO - NOTNLM OT - Decision tree OT - Humanitarian patients OT - Pulmonary valve-sparing repair OT - Tetralogy of fallot COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/03/03 00:30 MHDA- 2026/06/27 18:37 PMCR- 2026/03/02 CRDT- 2026/03/02 23:53 PHST- 2025/07/02 00:00 [received] PHST- 2026/01/24 00:00 [accepted] PHST- 2026/06/27 18:37 [medline] PHST- 2026/03/03 00:30 [pubmed] PHST- 2026/03/02 23:53 [entrez] PHST- 2026/03/02 00:00 [pmc-release] AID - 10.1186/s13019-026-03882-8 [pii] AID - 3882 [pii] AID - 10.1186/s13019-026-03882-8 [doi] PST - epublish SO - J Cardiothorac Surg. 2026 Mar 2;21(1):161. doi: 10.1186/s13019-026-03882-8. PMID- 41772526 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2474 (Electronic) IS - 1471-2474 (Linking) VI - 27 IP - 1 DP - 2026 Mar 3 TI - Changes in upper limb kinematics in children with cerebral palsy after lower limb surgery: a retrospective comparative study. LID - 10.1186/s12891-026-09692-2 [doi] LID - 297 AB - BACKGROUND: Cerebral palsy (CP), which is characterized by movement and posture disorders, is a neurological disorder that affects the movement of both the lower and upper extremities. Current research on gait analysis in children with cerebral palsy is mostly focused on the lower extremities, whereas research on the upper extremities is limited to three-dimensional gait analysis. However, in many countries, video-based gait analysis is used instead of three-dimensional gait analysis owing to its high cost. The primary aim of this study was to determine whether upper extremity kinematics change after lower extremity surgery in children with cerebral palsy. As a secondary aim, we developed a video-based analysis method to assess these changes in settings where 3D gait analysis is not available. METHODS: The study included 30 children (17 diplegic and 13 hemiplegic including 18 boys and 12 girls) with a mean age of 8.9 years and 29 healthy children (15 boys and 14 girls) with a mean age of 9.3 years. The efficacy of the surgical procedure was determined using Edinburgh Visual Gait Scores before and after surgery. Bilateral upper limb kinematics, including wrist, elbow, shoulder, trunk, and head flexion/extension angles, as well as trunk and head lateral flexion and shoulder abduction in the coronal plane, were measured during the initial contact and mid-stance phases using Kinovea 0.9.5 software by 2 different observers. Measurements from the more and less affected sides in the CP group were compared with corresponding limbs of the healthy control group. Preoperative, postoperative, and control groups were compared by ANOVA. The ICC test was used to evaluate the interobserver reliability between the 2 observers. Wilcoxon signed-rank test was used to compare EVGS scores. RESULTS: Postoperative outcomes at the wrist and elbow were found to differ in the sagittal plane, with notable adjustments in the flexion/extension angles during the initial contact and midstance phases. In addition, compared with those in the preoperative phase, the Edinburgh Scale (Edinburgh) score showed favorable postoperative improvements. Postoperative improvements were observed in wrist and elbow kinematics, with values approaching those of the control group. Interobserver reliability was excellent for most sagittal plane measurements (ICC > 0.90). CONCLUSIONS: This study revealed changes in the kinematics of the upper extremities after lower extremity surgery. These findings demonstrates that video-based analysis can provide reliable measurements of upper limb kinematics in settings where 3D gait analysis is not available. TRIAL REGISTRATION: This study was registered with ClinicalTrials.gov, number NCT05957783, titled "Changes in Upper Limb Kinematics in Children with Cerebral Palsy After Lower Limb Surgery." The trial was publicly registered on 07/24/2023 to ensure transparency and reproducibility of the research process. Although the data were analyzed retrospectively, the study protocol was prospectively registered at ClinicalTrials.gov (NCT05957783) to ensure transparency. The party responsible for the trial registration was Yasar Samet Gokceoglu, which is contactable via sametgokceoglu@gmail.com. FAU - Gokceoglu, Yasar Samet AU - Gokceoglu YS AD - Department of Orthopedics and Traumatology, University of Health Sciences Mehmet Akif Inan Research and Training Hospital, Sanliurfa, Turkey. sametgokceoglu@gmail.com. FAU - Bilgili, Fuat AU - Bilgili F AD - Department of Orthopedics and Traumatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. FAU - Sardogan, Cansu AU - Sardogan C AD - Istanbul Faculty of Medicine, Physical Therapy and Rehabilitation, Istanbul University, Istanbul, Turkey. FAU - Koyuncu, Daghan AU - Koyuncu D AD - Department of Orthopedics and Traumatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. FAU - Demirel, Mehmet AU - Demirel M AD - Department of Orthopedics and Traumatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. FAU - Akalan, Ekin AU - Akalan E AD - Istanbul Faculty of Medicine, Physical Therapy and Rehabilitation, Istanbul University, Istanbul, Turkey. LA - eng SI - ClinicalTrials.gov/NCT05957783 PT - Comparative Study PT - Journal Article DEP - 20260303 PL - England TA - BMC Musculoskelet Disord JT - BMC musculoskeletal disorders JID - 100968565 SB - IM MH - Humans MH - Male MH - Female MH - *Cerebral Palsy/surgery/physiopathology/diagnosis MH - Child MH - Biomechanical Phenomena/physiology MH - Retrospective Studies MH - *Upper Extremity/physiopathology/surgery MH - *Lower Extremity/surgery/physiopathology MH - Treatment Outcome MH - Video Recording MH - Gait Analysis MH - Adolescent MH - Hemiplegia/surgery/physiopathology MH - Range of Motion, Articular PMC - PMC13067493 OTO - NOTNLM OT - Cerebral palsy OT - Diplegia OT - Gait analysis OT - Hemiplegia OT - Kinovea COIS- Declarations. Ethics approval and consent to participate: This retrospective study was approved by the Ethics Committee of Istanbul University Istanbul Faculty of Medicine, Istanbul, Turkey (decision number 2023/801, dated 28 April 2023). The requirement for informed consent was waived by the ethics committee because the study involved only retrospective analysis of anonymized gait laboratory records. Written informed consent for participation and video recording was, however, obtained from the parents or legal guardians at the time of the original gait analyses, in accordance with institutional policy and the Declaration of Helsinki. Consent for publication: Written informed consent was obtained from the parents/legal guardians of all participants for publication of anonymized images. For Fig. 2, consent for publication of the image was specifically obtained, and identifiable facial features have been blurred to ensure confidentiality. Competing interests: The authors declare no competing interests. EDAT- 2026/03/03 00:30 MHDA- 2026/06/28 00:38 PMCR- 2026/03/03 CRDT- 2026/03/02 23:48 PHST- 2024/03/17 00:00 [received] PHST- 2026/02/27 00:00 [accepted] PHST- 2026/06/28 00:38 [medline] PHST- 2026/03/03 00:30 [pubmed] PHST- 2026/03/02 23:48 [entrez] PHST- 2026/03/03 00:00 [pmc-release] AID - 10.1186/s12891-026-09692-2 [pii] AID - 9692 [pii] AID - 10.1186/s12891-026-09692-2 [doi] PST - epublish SO - BMC Musculoskelet Disord. 2026 Mar 3;27(1):297. doi: 10.1186/s12891-026-09692-2. PMID- 41772507 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Mar 2 TI - Prediction tool for independent walking in children with dyskinetic cerebral palsy: a modeling study. LID - 10.1186/s12887-026-06649-1 [doi] LID - 272 AB - PURPOSE: Independent walking in children with Dyskinetic Cerebral Palsy (DCP) profoundly influences long-term quality of life.However, studies on the relationship between independent walking and high-risk factors in children with Dyskinaetic Cerebral Palsy (DCP) remain limited, and a predictive model for independent walking in this population has not yet been established.This study aimed to develop and validate a nomogram model based on multivariate clinical indicators to predict the probability of achieving independent walking by 7 years of age, thereby supporting early clinical decision-making and individualized rehabilitation planning. METHODS: The study was registered with the Chinese Clinical Trial Registry (Registration number: ChiCTR2300068075) on February 6, 2023. This retrospective study included 456 children with DCP registered in the Henan Provincial Children's Cerebral Palsy Registration Management Platform and the medical record system of the Third Affiliated Hospital of Zhengzhou University from January 2004 to December 2022. The primary outcome was independent walking achieved at or before age 7. Follow-up was conducted through on-site assessments and telephone/WeChat interviews from January 2023 to December 2024. Using the R caret package, participants were randomly divided into training and validation sets (7:3 ratio). Independent predictors were identified through univariate and multivariate Cox regression analyses, and a nomogram was constructed. Model performance was assessed using the concordance index (C-index), Area Under the Receiver Operating Characteristic Curve (AUC), calibration curves, and Decision Curve Analysis (DCA). RESULTS: Of the 456 children, 167 (36.60%) achieved independent walking at or before age 7. The numbers of children achieving independent walking at ages 2 to 7 were 17 (3.73%), 20 (4.38%), 25 (5.48%), 25 (5.48%), 33 (7.23%), and 47 (10.30%), respectively. Multivariate Cox regression identified neonatal seizures, cognitive impairment, GMFCS level at 2 years, epilepsy, and independent sitting before age 2 as significant predictors (P < 0.05). The nomogram demonstrated excellent discrimination, with a C-index of 0.926 in the training set and 0.942 in the validation set. Calibration curves indicated strong agreement between predicted and observed outcomes, and DCA confirmed substantial clinical net benefit within the threshold probability range of 4-7 years. CONCLUSION: We developed and validated a clinically applicable nomogram model for predicting independent walking by age 7 in children with DCP. Key predictors included early sitting ability, GMFCS level at 2 years, cognitive impairment, neonatal seizures, and epilepsy. This quantitative tool supports individualized rehabilitation strategies, facilitates informed clinical decisions, and may improve long-term outcomes for affected children. FAU - Qiao, Lusha AU - Qiao L AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. AD - Department of Pediatrics, Anyang People's Hospital, Anyang, Henan, 455000, China. FAU - Chen, Gongxun AU - Chen G AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. FAU - Wang, Yiwen AU - Wang Y AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. FAU - Cheng, Zhiwei AU - Cheng Z AD - Medical Records Management Department, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. FAU - Hui, Zhichong AU - Hui Z AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. FAU - Gao, Wenli AU - Gao W AD - Department of Pediatrics, Anyang People's Hospital, Anyang, Henan, 455000, China. FAU - Shi, Kaili AU - Shi K AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. FAU - Wang, Mingmei AU - Wang M AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. FAU - Ding, Xuexing AU - Ding X AD - Department of Pediatrics, Anyang People's Hospital, Anyang, Henan, 455000, China. FAU - Wang, Yongxia AU - Wang Y AD - Department of Pediatrics, Anyang People's Hospital, Anyang, Henan, 455000, China. FAU - Zhang, Guangyu AU - Zhang G AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. FAU - Yang, Lei AU - Yang L AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. FAU - Li, Sansong AU - Li S AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. FAU - Zhu, Dengna AU - Zhu D AD - Department of Rehabilitation Medicine, Department of Paediatrics, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. zhudengna@126.com. AD - Institute of Neuroscience, Zhengzhou University, Zhengzhou, 450001, Henan, China. zhudengna@126.com. AD - Key Laboratory of Pediatrics Brain Injury in Henan Province, Henan Provincial Pediatrics Clinical Medical Research Centre, The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, Henan, China. zhudengna@126.com. LA - eng SI - ChiCTR/ChiCTR2300068075 GR - 232102310135/Key R&D and Promotion Special Project (Science and Technology Tackling) of Henan Province/ GR - SBGJ202402069/Key Project of Medical Science and Technology Tackling Plan of Henan Province 2024/ PT - Journal Article PT - Validation Study DEP - 20260302 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology/rehabilitation MH - Child MH - Retrospective Studies MH - Female MH - *Walking MH - Male MH - *Nomograms MH - Child, Preschool PMC - PMC13059563 OTO - NOTNLM OT - Dyskinetic cerebral palsy OT - Independent walking OT - Nomogram OT - Prediction model COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki. The research protocol was approved by the Ethics Committee of the Third Affiliated Hospital of Zhengzhou University (Ethic Approval No. 2022-369-01) and registered with the Chinese Clinical Trial Registry (ChiCTR2300068075) before initiation. Informed consent was waived for retrospective data, but obtained from families for follow-up. Competing interests: The authors declare no competing interests. EDAT- 2026/03/03 00:30 MHDA- 2026/06/27 12:37 PMCR- 2026/03/02 CRDT- 2026/03/02 23:47 PHST- 2025/12/07 00:00 [received] PHST- 2026/02/13 00:00 [accepted] PHST- 2026/06/27 12:37 [medline] PHST- 2026/03/03 00:30 [pubmed] PHST- 2026/03/02 23:47 [entrez] PHST- 2026/03/02 00:00 [pmc-release] AID - 10.1186/s12887-026-06649-1 [pii] AID - 6649 [pii] AID - 10.1186/s12887-026-06649-1 [doi] PST - epublish SO - BMC Pediatr. 2026 Mar 2;26(1):272. doi: 10.1186/s12887-026-06649-1. PMID- 41771441 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1541-6100 (Electronic) IS - 0022-3166 (Print) IS - 0022-3166 (Linking) VI - 156 IP - 5 DP - 2026 May TI - Marine n-3 Long-Chain Polyunsaturated Fatty Acid Intake in Pregnancy and Risk of Early Life Infections in 3 Nordic Cohorts: A HEDIMED Consortium Study. PG - 101456 LID - S0022-3166(26)00105-7 [pii] LID - 10.1016/j.tjnut.2026.101456 [doi] LID - 101456 AB - BACKGROUND: n-3 (omega-3) long-chain polyunsaturated fatty acids (n-3 LCPUFAs) have anti-inflammatory effects that may influence immune-mediated diseases. OBJECTIVES: We investigated whether higher maternal pregnancy intake of n-3 LCPUFA is associated with a lower incidence of infections in young children. METHODS: We used data from 3 Nordic cohorts: the Norwegian Mother, Father and Child Cohort study (MoBa, n = 76,026), the Finnish Diabetes Prediction and Prevention Study (DIPP, n = 560), and the Copenhagen Prospective Studies on Asthma in Childhood 2010 cohort (COPSAC(2010), n = 680). Childhood infections up to age 36 mo were assessed using questionnaires in MoBa, coxsackievirus B 1-6 (CVB1-6) neutralizing antibodies in DIPP, and pathogenic viral PCR identification from acute respiratory episodes in COPSAC(2010). Maternal n-3 LCPUFA intake was assessed through validated food frequency questionnaires in MoBa and DIPP, whereas COPSAC(2010) used a randomized trial design where pregnant women received fish oil capsules or a placebo. RESULTS: Higher n-3 LCPUFA intake was not significantly associated with lower respiratory tract infection (adjusted incidence rate ratio [aIRR]: 0.99; 95% CI: 0.94-1.03) but was associated with a reduced risk of upper respiratory tract infections (aIRR: 0.99; 95% CI: 0.98-0.99) and gastroenteritis (aIRR: 0.96; 95% CI: 0.95-0.98) per g/d up to age 36 mo in MoBa. The DIPP study found no association between n-3 LCPUFA intake and having >/=1 CVB infection (adjusted odds ratio: 1.74; 95% CI: 0.64-4.72, per g/d). The COPSAC(2010) trial found no significant effects of the intervention for pathogen-specific respiratory episodes (IRR: 0.86; 95% CI: 0.69-1.07). CONCLUSIONS: This study does not provide consistent evidence that higher maternal n-3 LCPUFA pregnancy intake reduces the risk of infections in early childhood. CLINICAL TRIAL REGISTRY: This trial was registered as NCT00798226, https://clinicaltrials.gov/study/NCT00798226. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Rantala, Aino K AU - Rantala AK AD - Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway; Center for Environmental and Respiratory Health Research (CERH), Research Unit of Population Health, University of Oulu, Oulu, Finland. Electronic address: aino.rantala@oulu.fi. FAU - Hakola, Leena AU - Hakola L AD - Department of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland; Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, Finland; Tampere University Hospital, Research, Development and Innovation Center, Tampere, Finland. Electronic address: leena.hakola@tuni.fi. FAU - Brustad, Nicklas AU - Brustad N AD - Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, Copenhagen, Denmark. FAU - Tapia, German AU - Tapia G AD - Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway. FAU - Hard Af Segerstad, Elin M AU - Hard Af Segerstad EM AD - Department of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Celiac Disease and Diabetes Unit, Clinical Sciences Malmoe, Lund University, Malmoe, Sweden. FAU - Lehtonen, Jussi AU - Lehtonen J AD - Department of Virology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. FAU - Thorsen, Jonathan AU - Thorsen J AD - Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Akerlund, Mari AU - Akerlund M AD - Department of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland; Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, Finland. FAU - Parr, Christine L AU - Parr CL AD - Norwegian Scientific Committee for Food and Environment, Oslo, Norway. FAU - Magnus, Maria C AU - Magnus MC AD - Centre for Fertility and Health, Norwegian Institute of Public Health, Oslo, Norway. FAU - Lund-Blix, Nicolai A AU - Lund-Blix NA AD - Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway; The Norwegian Childhood Diabetes Registry, Division of Childhood and Adolescent Medicine, Oslo University Hospital, Oslo, Norway. FAU - Stokholm, Jakob AU - Stokholm J AD - Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, Copenhagen, Denmark; Department of Food Science, University of Copenhagen, Frederiksberg C, Denmark. FAU - Knip, Mikael AU - Knip M AD - Research Program for Clinical and Molecular Metabolism, Faculty of Medicine, University of Helsinki, Helsinki, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland. FAU - Toppari, Jorma AU - Toppari J AD - Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, and Centre for Population Health Research, and InFLAMES Research Centre, University of Turku, Turku, Finland; Department of Pediatrics, Turku University Hospital, Turku, Finland. FAU - Stordal, Ketil AU - Stordal K AD - Department of Paediatric and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Department of Paediatric Research, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway. FAU - Veijola, Riitta AU - Veijola R AD - Department of Pediatrics, PEDEGO Research Unit, Medical Research Center, University of Oulu, Oulu, Finland; Department of Children and Adolescents, Oulu University Hospital, Oulu, Finland. FAU - Hyoty, Heikki AU - Hyoty H AD - Department of Virology, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; Department of Pediatrics, Tampere University Hospital, Tampere, Finland; Fimlab Laboratories, Tampere, Finland. FAU - Virtanen, Suvi M AU - Virtanen SM AD - Department of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland; Faculty of Social Sciences, Unit of Health Sciences, Tampere University, Tampere, Finland; Tampere University Hospital, Research, Development and Innovation Center, Tampere, Finland; Center for Child, Adolescent and Maternal Health Research, Tampere University and Tampere University Hospital, Tampere. FAU - Bonnelykke, Klaus AU - Bonnelykke K AD - Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, Copenhagen, Denmark; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Stene, Lars C AU - Stene LC AD - Department of Chronic Diseases, Norwegian Institute of Public Health, Oslo, Norway. CN - HEDIMED Investigator Group LA - eng SI - ClinicalTrials.gov/NCT00798226 GR - N01ES75558/ES/NIEHS NIH HHS/United States GR - U01 NS047537/NS/NINDS NIH HHS/United States PT - Journal Article PT - Observational Study DEP - 20260228 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 RN - 0 (Fatty Acids, Omega-3) RN - 0 (Fish Oils) SB - IM MH - Adult MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - Pregnancy MH - Cohort Studies MH - *Fatty Acids, Omega-3/administration & dosage/pharmacology MH - Finland/epidemiology MH - Fish Oils/administration & dosage MH - *Infections/epidemiology MH - *Maternal Nutritional Physiological Phenomena MH - Norway/epidemiology MH - Prospective Studies MH - Risk Factors MH - Randomized Controlled Trials as Topic PMC - PMC13197902 OTO - NOTNLM OT - COPSAC OT - DIPP OT - MoBa OT - childhood OT - cohort study OT - dietary fatty acids OT - infections OT - pregnancy COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/03/03 00:30 MHDA- 2026/05/09 00:33 PMCR- 2026/02/28 CRDT- 2026/03/02 19:13 PHST- 2025/12/29 00:00 [received] PHST- 2026/02/13 00:00 [revised] PHST- 2026/02/24 00:00 [accepted] PHST- 2026/05/09 00:33 [medline] PHST- 2026/03/03 00:30 [pubmed] PHST- 2026/03/02 19:13 [entrez] PHST- 2026/02/28 00:00 [pmc-release] AID - S0022-3166(26)00105-7 [pii] AID - 101456 [pii] AID - 10.1016/j.tjnut.2026.101456 [doi] PST - ppublish SO - J Nutr. 2026 May;156(5):101456. doi: 10.1016/j.tjnut.2026.101456. Epub 2026 Feb 28. PMID- 41770833 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260920 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 1 DP - 2026 Mar TI - Toward Authentic Resources Among Mothers: Impact of Cyberchondria on Maternal Self-Efficacy and Breastfeeding Competency. PG - e70166 LID - 10.1111/mcn.70166 [doi] LID - e70166 AB - The postpartum period is a critical stage where maternal confidence and self-efficacy significantly influence breastfeeding success and overall adjustment. Cyberchondria refers to the repetitive searching for health-related information online, which can lead mothers to doubt their caregiving abilities, lower their confidence, and negatively impact their perceived competence in breastfeeding and infant care. This study explored the relationship between cyberchondria, maternal self-efficacy, and breastfeeding perceived competency among postpartum mothers. A cross-sectional survey was conducted with 300 mothers within 2 months of childbirth, recruited through a two-stage random sampling method from primary health care facilities in Zagazig district, Egypt. Participants completed validated Arabic versions of the Cyberchondria Scale (CS), the Perceived Maternal Parenting Self-Efficacy Scale, and the breastfeeding competency scale (BCS). Findings revealed that higher cyberchondria levels were linked with lower maternal self-efficacy and diminished breastfeeding competency. Maternal self-efficacy demonstrated a significant positive association with breastfeeding perceived competency and partially mediated the relationship between cyberchondria and breastfeeding competency. These results suggest that online health-seeking behaviors may undermine maternal confidence and skills, highlighting the importance of incorporating digital health literacy interventions into postpartum care. Supporting mothers in navigating online health information effectively may enhance self-efficacy and improve breastfeeding outcomes. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Amin, Shaimaa Mohamed AU - Amin SM AUID- ORCID: 0000-0001-9467-3211 AD - Department of Community, Psychiatric, and Mental Health Nursing, College of Nursing, Qassim University, Buraydah, Saudi Arabia. FAU - Hamad, Nagwa Ibrahim Mohamed AU - Hamad NIM AUID- ORCID: 0000-0002-5133-4620 AD - Nursing Department, College of Pharmacy, Nursing and Medical Sciences, Riyadh Elm University, Riyadh, Saudi Arabia. FAU - Elsheikh, Mahmoud Ahmed AU - Elsheikh MA AD - Nursing Department, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Wadi Addawasir, Saudi Arabia. AD - Community Health Nursing Department, Faculty of Nursing, Cairo University, Cairo, Egypt. FAU - El-Razek, Doaa Kadry Mahmoud Abd AU - El-Razek DKMA AD - Lecturer of Community Health Nursing, Faculty of Nursing, Zagazig University, Egypt. FAU - Hanbaly, Esraa Mohammed Abd El Aziz Al AU - Hanbaly EMAEAA AD - Lecturer of Community Health Nursing, Faculty of Nursing, Zagazig University, Egypt. FAU - Bahri, Hibah Abdulrahim AU - Bahri HA AUID- ORCID: 0000-0001-5258-873X AD - Medical-Surgical Nursing Department, College of Nursing, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Abdelaliem, Sally Mohammed Farghaly AU - Abdelaliem SMF AUID- ORCID: 0000-0001-6497-0952 AD - Department of Nursing, Faculty of Allied Health Sciences, Princess Nourah bint Abdulrahman University, Kuwait City, Kuwait. AD - Department of Nursing Administration, Faculty of Nursing, Alexandria University, Alexandria, Egypt. FAU - El-Gazar, Heba Emad AU - El-Gazar HE AUID- ORCID: 0000-0002-0185-859X AD - College of Nursing, Imam Mohamed Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia. FAU - Zoromba, Mohamed Ali AU - Zoromba MA AUID- ORCID: 0000-0002-4298-1121 AD - Nursing College, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia. FAU - Ouda, Marwa Mohamed Ahmed AU - Ouda MMA AD - Department of Maternal and Child Health Nursing, College of Nursing, Jouf University, Jouf, Sakaka, Saudi Arabia. AD - Department of Pediatric Nursing, Faculty of Nursing, Damanhour University, Egypt. FAU - Mokbel, Rodaina Ahmed AU - Mokbel RA AD - Pediatric Nursing, Faculty of Nursing, Damanhour University, Egypt. FAU - Atta, Mohamed Hussein Ramadan AU - Atta MHR AUID- ORCID: 0000-0002-5518-0892 AD - Nursing Department, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Wadi Addawasir, Saudi Arabia. AD - Lecturer of Psychiatric and Mental Health Nursing, Faculty of Nursing, Alexandria University, Alexandria, Egypt. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - *Self Efficacy MH - Female MH - *Breast Feeding/psychology MH - Cross-Sectional Studies MH - Adult MH - *Mothers/psychology/statistics & numerical data MH - Postpartum Period/psychology MH - Egypt MH - Internet MH - Young Adult MH - Surveys and Questionnaires PMC - PMC12952542 OTO - NOTNLM OT - breastfeeding OT - cyberchondria OT - internet OT - mothers OT - self-concept OT - self-efficacy COIS- The authors declare no conflicts of interest. EDAT- 2026/03/02 18:57 MHDA- 2026/03/08 06:38 PMCR- 2026/03/02 CRDT- 2026/03/02 13:52 PHST- 2025/11/02 00:00 [revised] PHST- 2025/03/18 00:00 [received] PHST- 2026/01/07 00:00 [accepted] PHST- 2026/03/08 06:38 [medline] PHST- 2026/03/02 18:57 [pubmed] PHST- 2026/03/02 13:52 [entrez] PHST- 2026/03/02 00:00 [pmc-release] AID - MCN70166 [pii] AID - 10.1111/mcn.70166 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Mar;22(1):e70166. doi: 10.1111/mcn.70166. PMID- 41770229 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20261010 IS - 2523-899X (Electronic) IS - 2523-899X (Linking) VI - 46 IP - 2 DP - 2026 Apr TI - Using Immune Clusters for Classifying Heterogeneity of Immunity in Healthy Adults. PG - 367-381 LID - 10.1007/s11596-026-00170-3 [doi] AB - OBJECTIVE: Quantification of immunity is a challenge in clinical practice due to the complexity and heterogeneity of immune cells. This study aimed to establish comprehensive reference ranges for immune indicators and characterize immune heterogeneity in healthy adults. METHODS: A total of 115 healthy adults aged 18-65 years were enrolled. Sixty immune indicators encompassing natural immunity (NK cells, monocytes, dendritic cells, myeloid-derived suppressor cells), cellular immunity (T cells, regulatory T cells, T follicular helper cells, T helper cells), and humoral immunity (B cells), along with nutritional and metabolic indicators, were simultaneously detected. Flow cytometry was used to measure the number, phenotype, and functional subsets of immune cells. Unsupervised k-means clustering was performed to identify immune subtypes. RNA-sequencing was conducted on representative individuals from each cluster for transcriptomic validation. RESULTS: The reference ranges for 60 immune indicators were established, with over half (38/60) exhibiting coefficient of variation > 30%, indicating substantial heterogeneity. Gender differences were minimal, whereas age-related changes were pronounced in adaptive immune cells. Specifically, human leukocyte antigen DR-positive (HLA-DR(+)) T cells (%) increased from 20.76% +/- 7.75% (18-30 years) to 30.06% +/- 10.82% (51-65 years, P = 0.001), while CD45RA(+) regulatory T (Treg) cells (%) and naive CD8(+) T cells (%) decreased progressively with age (P < 0.001). Correlation analysis between immune cells and routine laboratory indicators revealed that nutritional indicators like albumin (ALB) were positively correlated with the number of immune cells such as CD8(+) T cells, while lipid metabolism indicators like low-density lipoprotein (LDL) were negatively correlated with T helper cell differentiation (P < 0.01). Clustering analysis identified three distinct immune subtypes: "potential type" (26.1%, n = 30) characterized by high naive T cells (44.91% +/- 9.88% CD4(+) T cells, 33.86% +/- 13.82% CD8(+) T cells) and CD1c-positive myeloid dendritic cells (CD1c(+) mDCs) (45.17% +/- 11.58%); "effector NK type" (34.8%, n = 45) with elevated NK cell count (704.22 +/- 280.79 cells/muL) and cytotoxic function (93.16% +/- 2.38% perforin(+) NK cells); and "effector T type" (39.1%, n = 40) distinguished by increased HLA-DR(+) T cells (19.48% +/- 7.1% CD4(+) T cells, 45.11% +/- 10.92% CD8(+) T cells) and effector memory (EM) CD4(+) T cells (37.85% +/- 11.01%). A further RNA-sequencing analysis confirmed the transcriptomic characteristics of different immune subtypes, which was in accordance with phenotype analysis. Specifically, adults in the potential type had strong adaptive immunity; those in the effector NK type showed upregulated NK cell-mediated cytotoxicity; those in the effector T type exhibited enhanced T-helper 1 immune responses. CONCLUSION: This study provides a systematic framework for immunity quantification by establishing reference ranges and classifying healthy adults into three immune subtypes with distinct metabolic and transcriptomic features. These findings could enhance understanding of immune heterogeneity in healthy individuals and guide personalized immune monitoring and intervention strategies in clinical practice. CI - (c) 2026. The Author(s), under exclusive licence to the Huazhong University of Science and Technology. FAU - Wu, Xiao-Hui AU - Wu XH AD - Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Huang, Yi AU - Huang Y AD - Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Zou, Si-Yu AU - Zou SY AD - Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Jiang, Kai-Shan AU - Jiang KS AD - Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Wu, Shi-Ji AU - Wu SJ AD - Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Hou, Hong-Yan AU - Hou HY AD - Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. FAU - Wang, Feng AU - Wang F AUID- ORCID: 0000-0001-6324-9135 AD - Department of Laboratory Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. fengwang@tjh.tjmu.edu.cn. LA - eng GR - 82372324/National Natural Science Foundation of China/ GR - 2022YFA1303500/National Key R&D Program of China/ PT - Journal Article DEP - 20260302 PL - China TA - Curr Med Sci JT - Current medical science JID - 101729993 SB - IM MH - Humans MH - Adult MH - Male MH - Middle Aged MH - Female MH - Adolescent MH - Aged MH - Young Adult MH - Clustering Algorithms MH - Reference Values MH - Killer Cells, Natural/immunology MH - *Immunity, Cellular MH - Dendritic Cells/immunology MH - Cluster Analysis MH - Flow Cytometry MH - Immunity, Humoral OTO - NOTNLM OT - Clustering analysis OT - Healthy adults OT - Immune characteristics OT - Immune heterogeneity OT - Lymphocytes OT - Nutritional indicators OT - Prediction model COIS- Declarations. Competing Interests: All authors declare that they have no competing interests. Consent for Publication: Written informed consent for publication was obtained from all participants included in this study. Participants consented to the publication of anonymized data and any identifiable materials associated with the research. Ethical Approval and Consent to Participate: This study was conducted in accordance with the principles of the Declaration of Helsinki and approved by the Ethics Committee of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (Approval No. TJ-IRB20211009). Written informed consent was obtained from all individual participants included in the study. Human and Animal Rights: This study involving human participants was conducted in accordance with the ethical standards of the Ethics Committee of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology (Approval No. TJIRB20211009) and with the principles of the Declaration of Helsinki. EDAT- 2026/03/02 13:16 MHDA- 2026/04/28 17:39 CRDT- 2026/03/02 11:03 PHST- 2025/05/06 00:00 [received] PHST- 2026/01/23 00:00 [accepted] PHST- 2026/01/19 00:00 [revised] PHST- 2026/04/28 17:39 [medline] PHST- 2026/03/02 13:16 [pubmed] PHST- 2026/03/02 11:03 [entrez] AID - 10.1007/s11596-026-00170-3 [pii] AID - 10.1007/s11596-026-00170-3 [doi] PST - ppublish SO - Curr Med Sci. 2026 Apr;46(2):367-381. doi: 10.1007/s11596-026-00170-3. Epub 2026 Mar 2. PMID- 41769920 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260302 LR - 20260813 IS - 2291-9279 (Print) IS - 2291-9279 (Electronic) VI - 14 DP - 2026 Mar 2 TI - Design and Iterative Development of Serious Exergames for Children With Autism Spectrum Disorder: Formative Multiple-Case Pilot Study. PG - e77727 LID - 10.2196/77727 [doi] LID - e77727 AB - BACKGROUND: Children with autism spectrum disorder (ASD) exhibit cognitive, motor, and social difficulties that affect engagement, causing developmental delays, behavioral challenges, and obesity-interrelated concerns in daily functioning and well-being. Although interactive interventions have incorporated physical activity, they often rely on limited physical involvement and lack iterative, expert-informed design, as built on pre-existing game frameworks. Physical activity is often operationalized as constrained input (eg, gestures or in-place actions) rather than exertion-intensive, whole-body exercise, and design guidance for adapting exercise content under ASD-oriented safety and cognitive-sensory constraints remains limited. These limitations highlight the need for exergames that promote sustained, full-body participation aligned with developmental goals, motivating formative, co-design with expertise and initial field testing in this population. OBJECTIVE: We aim to iteratively design exercise-based serious games (SGs) for children with ASD through a structured, expert-informed co-design process involving 21 professionals across special education, adapted physical education, and human-computer interaction, and to examine feasibility and use contexts through an exploratory multiple-case pilot study. METHODS: We derived serious exergames using 4 design methods-stakeholder interview, concept mapping, creative matrix, and visualize the vote. Two exergames-"Fruit Sorting Run" and "Hazard Avoiding Ride"-were developed, integrating full-body running and cycling movements into goal-directed tasks under ASD-oriented constraints. We conducted a multiple-case pilot with 3 children with ASD. During gameplay, caregivers labeled engagement using a binary input interface, and we conducted postsession caregiver interviews to capture complementary observations. RESULTS: Engagement in both exergames tended to increase over normalized time. Generalized estimating equations with a logit link and an autoregressive working correlation of order 1 (AR1), including participant indicators, showed a statistically significant association between normalized time and engagement in Fruit Sorting Run (per 0.1 increase: beta=0.48; odds ratio 1.62, 95% CI 1.09-2.38; P=.02) and Hazard Avoiding Ride (per 0.1 increase: beta=0.66; odds ratio 1.93, 95% CI 1.04-3.60, P=.04). Caregiver interviews reinforced these findings, reporting increased attention, motivation, and enjoyment across both activities. CONCLUSIONS: The findings support the applicability of an expert-informed design approach and the viability of the resulting exergames, integrating goal-directed physical activity, virtual agent-based prompting, and stakeholder-informed considerations such as motor-cognitive alignment, interactive scaffolding, and support for daily living skills. Distinct from prior SG approaches that operationalize physical activity through discrete gestures or in-place interactions, the proposed exergames embed sustained, exertion-intensive, whole-body movement within structured gameplay. Within this exploratory multiple-case pilot, engagement trajectories tended to increase over time. These preliminary observations provide an initial basis for a testable hypothesis that exertion-intensive, full-body SGs with virtual agent-based prompting may be associated with increasing engagement over time, meriting further examination in larger samples and applied educational and therapeutic contexts. CI - (c)Won Kim, Minwoo Seong, SeungJun Kim. Originally published in JMIR Serious Games (https://games.jmir.org), 02.03.2026. FAU - Kim, Won AU - Kim W AUID- ORCID: 0000-0001-6696-3756 AD - Department of AI Convergence, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. AD - Department of Computer Engineering, College of IT Convergence, Chosun University, Gwangju, Republic of Korea. FAU - Seong, Minwoo AU - Seong M AUID- ORCID: 0009-0007-5847-9666 AD - Department of AI Convergence, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. FAU - Kim, SeungJun AU - Kim S AUID- ORCID: 0000-0003-0470-2483 AD - Department of AI Convergence, Gwangju Institute of Science and Technology, Gwangju, Republic of Korea. LA - eng PT - Journal Article DEP - 20260302 PL - Canada TA - JMIR Serious Games JT - JMIR serious games JID - 101645255 PMC - PMC12993268 OTO - NOTNLM OT - autism spectrum disorder OT - children OT - design research OT - exergame OT - physical activity OT - serious game COIS- Conflicts of Interest: None declared. EDAT- 2026/03/02 13:16 MHDA- 2026/03/02 13:17 PMCR- 2026/03/02 CRDT- 2026/03/02 08:22 PHST- 2025/05/19 00:00 [received] PHST- 2026/01/13 00:00 [accepted] PHST- 2026/01/11 00:00 [revised] PHST- 2026/03/02 13:17 [medline] PHST- 2026/03/02 13:16 [pubmed] PHST- 2026/03/02 08:22 [entrez] PHST- 2026/03/02 00:00 [pmc-release] AID - v14i1e77727 [pii] AID - 10.2196/77727 [doi] PST - epublish SO - JMIR Serious Games. 2026 Mar 2;14:e77727. doi: 10.2196/77727. PMID- 41769799 OWN - NLM STAT- MEDLINE DCOM- 20260310 LR - 20260813 IS - 1369-7625 (Electronic) IS - 1369-6513 (Print) IS - 1369-6513 (Linking) VI - 29 IP - 2 DP - 2026 Apr TI - Exploring Challenges and Co-Developing a Nutritional Resource for Antenatal Care: A Participatory Stakeholder Engagement Study With Midwives and Public Involvement. PG - e70633 LID - 10.1111/hex.70633 [doi] LID - e70633 AB - BACKGROUND: It is important that midwives discuss good nutrition and optimal weight during antenatal appointments, yet this rarely happens. Earlier research suggests that limited time, plus insufficient knowledge and skills are barriers to this. AIM: To engage antenatal midwives in stakeholder discussions to explore their perspectives on the design and delivery of a nutrition resource. METHODS: This qualitative study used a Participatory Action Research (PAR) approach. Twenty-six midwives (19 community-based; 7 hospital-based) were purposely recruited from four NHS sites in Northwest England. Four stakeholder workshops were co-designed and facilitated by researchers. In Phase 1, midwives reflected on current practice and challenges in delivering diet and weight advice. In Phase 2, they co-developed ideas for practical, acceptable nutrition resources. Data collection included participant-generated artefacts, post-it notes, visual maps, field notes, and verbatim reflections. Data were analysed inductively using Reflexive Thematic Analysis, and reflexivity was maintained throughout, recognising researchers' influence within this participatory design. RESULTS: Two master themes were developed: (1) "We Want to Help, But We're Not Trained for This", highlighting systemic, professional, and emotional barriers to providing support and (2) "Make It Real and Make It Work", midwives' co-produced recommendations for inclusive tools and training that are realistic, culturally sensitive, and integrated into existing workflows. DISCUSSION AND CONCLUSION: Midwives expressed a clear need for improved education and resource support. Despite systemic constraints, they co-produced practical and implementable solutions. Supporting midwives through evidence-based, context-specific tools and training may enhance nutrition conversations in antenatal care and improve maternal and infant health outcomes. PATIENT OR PUBLIC CONTRIBUTION: Three culturally diverse Patient and Public Involvement (PPI) representatives were recruited to assist with the validation of the analytical findings. One was a midwife working in antenatal care; the second was a recent service user (a postnatal woman) with an Eastern European background, and the third was a midwife (currently on maternity leave) with a South American background. Commentary from these PPI representatives was used to validate the analysis and support the interpretation of the data. Additionally, they were invited to provide commentary on the draft manuscript and have been included as co-authors. CI - (c) 2026 The Author(s). Health Expectations published by John Wiley & Sons Ltd. FAU - Abayomi, Julie AU - Abayomi J AUID- ORCID: 0000-0002-8133-5595 AD - Health Research Institute, Edge Hill University, Ormskirk, UK. FAU - Richards, Helen AU - Richards H AD - Liverpool Women's Hospital NHS Trust, Liverpool, UK. FAU - Benavides, Camila AU - Benavides C AD - Liverpool Women's Hospital NHS Trust, Liverpool, UK. FAU - Reyneke, Ekaterina AU - Reyneke E FAU - Newson, Lisa AU - Newson L AUID- ORCID: 0000-0002-5874-8762 AD - School of Psychology, Liverpool John Moores University, Liverpool, UK. LA - eng GR - NIHR305789/National Institute for Health and Care Research/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - Health Expect JT - Health expectations : an international journal of public participation in health care and health policy JID - 9815926 SB - IM MH - Qualitative Research MH - *Midwifery/methods MH - Stakeholder Participation MH - Community-Based Participatory Research MH - *Prenatal Care/methods/psychology MH - England MH - *Counseling/methods MH - *Diet, Healthy/nursing MH - Humans MH - Female MH - Pregnancy MH - *Nurse Midwives/psychology MH - Professional Competence MH - Health Knowledge, Attitudes, Practice PMC - PMC12951540 OTO - NOTNLM OT - midwives OT - nutrition OT - pregnancy OT - weight COIS- The authors declare no conflicts of interest. EDAT- 2026/03/02 13:17 MHDA- 2026/03/07 06:39 PMCR- 2026/03/02 CRDT- 2026/03/02 07:23 PHST- 2025/07/31 00:00 [revised] PHST- 2025/05/28 00:00 [received] PHST- 2026/02/19 00:00 [accepted] PHST- 2026/03/07 06:39 [medline] PHST- 2026/03/02 13:17 [pubmed] PHST- 2026/03/02 07:23 [entrez] PHST- 2026/03/02 00:00 [pmc-release] AID - HEX70633 [pii] AID - 10.1111/hex.70633 [doi] PST - ppublish SO - Health Expect. 2026 Apr;29(2):e70633. doi: 10.1111/hex.70633. PMID- 41769455 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260302 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 1 DP - 2026 Jan TI - Internet Dietary Guidance for Pediatric Inflammatory Bowel Disease: A Quality and Readability Crisis. PG - e102398 LID - 10.7759/cureus.102398 [doi] LID - e102398 AB - BACKGROUND: Diet and nutritional therapy are treatment options for children with inflammatory bowel disease (IBD). Parents of children with medical conditions often turn to the internet for medical guidance. However, the quality and readability of internet dietary information for pediatric IBD are currently unknown. The objective of this study was to evaluate the quality and readability of websites about diet for pediatric IBD. METHODS: Top internet websites for the searches "IBD, diet, children," "Crohn's disease, diet, children," and "ulcerative colitis, diet, children" were rated using the DISCERN instrument, a validated tool for rating consumer health information, on a scale of 1-5 to assess reliability, information quality, and overall quality (5 = highest reliability or quality). The Flesch-Kincaid grade level (FKGL) was used to determine website readability. RESULTS: The mean reliability scores were 3.1 for searches on "IBD, diet, children," 3.0 for "Crohn's disease, diet, children," and 3.1 for "ulcerative colitis, diet, children." The corresponding mean information quality scores were 2.5, 2.5, and 2.4, and the mean overall quality scores were 2.8, 2.7, and 2.9. The mean reading grade levels required to understand the content per FKGL were 11.9, 10.8, and 11.1. Across the websites, 23 highly variable dietary recommendations were made. CONCLUSIONS: For internet search results about diet and pediatric IBD, mean scores indicated moderate website reliability but poor information quality and overall quality. Websites were written at approximately an 11th-grade reading level, above the recommended standard for patient education. Dietary recommendations were numerous and inconsistent. CI - Copyright (c) 2026, Donaldson et al. FAU - Donaldson, Rachel A AU - Donaldson RA AD - Pediatric Gastroenterology, Duke University School of Medicine, Durham, USA. FAU - Miller, Nicole F AU - Miller NF AD - Pediatric Gastroenterology, Duke University School of Medicine, Durham, USA. FAU - Chumpitazi, Bruno P AU - Chumpitazi BP AD - Pediatric Gastroenterology, Duke University School of Medicine, Durham, USA. FAU - Lyles, John L AU - Lyles JL AD - Pediatric Gastroenterology, Duke University School of Medicine, Durham, USA. LA - eng PT - Journal Article DEP - 20260127 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12937026 OTO - NOTNLM OT - crohn's disease OT - diet OT - internet OT - nutrition OT - pediatric inflammatory bowel disease OT - readability OT - ulcerative colitis COIS- Human subjects: All authors have confirmed that this study did not involve human participants or tissue. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/03/02 13:17 MHDA- 2026/03/02 13:18 PMCR- 2026/01/27 CRDT- 2026/03/02 06:49 PHST- 2026/01/26 00:00 [accepted] PHST- 2026/03/02 13:18 [medline] PHST- 2026/03/02 13:17 [pubmed] PHST- 2026/03/02 06:49 [entrez] PHST- 2026/01/27 00:00 [pmc-release] AID - 10.7759/cureus.102398 [doi] PST - epublish SO - Cureus. 2026 Jan 27;18(1):e102398. doi: 10.7759/cureus.102398. eCollection 2026 Jan. PMID- 41769120 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Associations of physical activity, disordered eating, and depressive symptoms with academic performance among Saudi university students. PG - 1769363 LID - 10.3389/fpubh.2026.1769363 [doi] LID - 1769363 AB - BACKGROUND AND OBJECTIVES: Academic performance is shaped by various behavioral and psychological factors. However, the effects of physical activity, depressive symptoms, and disordered eating on academic success, particularly among university students in Saudi Arabia, remain underexplored. This study investigates the individual and combined associations of these factors on GPA among Saudi university students. MATERIALS AND METHODS: A cross-sectional survey was conducted from December 2024 to June 2025 involving a non-probability convenience sample of 400 students from various Saudi universities. Data were collected using validated instruments, including the International Physical Activity Questionnaire-Short Form (IPAQ-SF), the Patient Health Questionnaire-9 (PHQ-9) for assessing depression, and the Eating Disorder Examination Questionnaire-Short Form (EDE-QS). Descriptive statistics, chi-square tests, and multiple linear regression analyses were utilized to identify associations and predictors of academic performance. RESULTS: The majority of participants were female (79.8%) with a median age of 21. More than half (53%) reported low levels of physical activity, and 50.7% exhibited clinically significant depressive symptoms. Elevated behavioral symptoms of disordered eating, assessed using the behavioral subscale of the EDE-QS, were commonly observed among participants. Regression analysis showed that adherence to WHO-recommended physical activity levels, enrolment in medical disciplines, and lower behavioral symptoms of eating disorders were associated with higher GPA. In contrast, depression and cognitive eating concerns were not meaningfully associated with academic performance. CONCLUSION: Physical activity and disordered eating behaviors play a crucial role in influencing academic performance among Saudi university students, while depression, despite its high prevalence, did not serve as an independent predictor of GPA. These findings highlight the necessity of implementing integrated health promotion strategies within academic institutions that address both mental health and lifestyle behaviors to enhance student success. CI - Copyright (c) 2026 Alotaibi, Alghamdi, Almousa, Almalkia, Alfaifi, Alturki, Alkahal, Asiri, Almuzaini, Alshahrani, Alqabbani, Almuwais and Alahmari. FAU - Alotaibi, Madawi AU - Alotaibi M AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alghamdi, Farah AU - Alghamdi F AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Almousa, Nourah AU - Almousa N AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Almalkia, Roaa AU - Almalkia R AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alfaifi, Reema AU - Alfaifi R AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. AD - Public Health Program, King Saud bin Abdulaziz University for Health Sciences (KSAU-HS), Riyadh, Saudi Arabia. FAU - Alturki, Hisaah AU - Alturki H AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alkahal, Hathil AU - Alkahal H AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Asiri, Ruba AU - Asiri R AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Almuzaini, Muzun AU - Almuzaini M AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alshahrani, Ghaday AU - Alshahrani G AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alqabbani, Samiah AU - Alqabbani S AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Almuwais, Afrah AU - Almuwais A AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alahmari, Wafa AU - Alahmari W AD - Department of Rehabilitation Sciences, College of Health and Rehabilitation Sciences, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260212 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Female MH - Male MH - Cross-Sectional Studies MH - *Students/psychology/statistics & numerical data MH - Universities MH - *Depression/epidemiology/psychology MH - Young Adult MH - *Exercise/psychology MH - *Feeding and Eating Disorders/epidemiology/psychology MH - *Academic Performance/statistics & numerical data MH - Surveys and Questionnaires MH - Adolescent MH - Adult MH - Academia PMC - PMC12935905 OTO - NOTNLM OT - GPA OT - academic performance OT - depression OT - eating disorders OT - lifestyle behaviors OT - mental health OT - physical activity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/02 13:17 MHDA- 2026/03/06 13:44 PMCR- 2026/02/12 CRDT- 2026/03/02 06:46 PHST- 2025/12/16 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/03/06 13:44 [medline] PHST- 2026/03/02 13:17 [pubmed] PHST- 2026/03/02 06:46 [entrez] PHST- 2026/02/12 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1769363 [doi] PST - epublish SO - Front Public Health. 2026 Feb 12;14:1769363. doi: 10.3389/fpubh.2026.1769363. eCollection 2026. PMID- 41768591 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260926 IS - 1520-6394 (Electronic) IS - 1091-4269 (Print) IS - 1091-4269 (Linking) VI - 2026 DP - 2026 TI - Development and External Validation of a Prediction Model to Identify Suicide Attempters in Treatment-Naive Adolescents With Major Depressive Disorder. PG - 7216497 LID - 10.1155/da/7216497 [doi] LID - 7216497 AB - BACKGROUND: Suicidal behavior in adolescents poses a significant risk, and suicide attempts are the strongest predictors of suicide death. Patients with Major Depressive Disorder (MDD) are at high risk of attempting suicide. However, there is still a lack of effective tools in clinical settings to identify these suicide attempters. METHODS: The study assessed suicidal attempts and their predictive factors in adolescents first diagnosed with MDD from August 1, 2022, to May 31, 2024. Five algorithms were used for model construction: logistic regression, random forest, decision tree, support vector machine, and XGBoost. Finally, we evaluated the performance of the best model using an independent external validation set. RESULTS: The study included 820 untreated adolescent first-visit MDD patients (618 females [75.4%], average age 14.67 +/- 1.69 years). Of these, 481 (58.7%) had disclosed suicidal ideation to others, and 299 (36.5%) reported having attempted suicide. Predictive variables for the outcome included age, grade, BMI z-score, levels of depression and anxiety, sleep quality, history of being left behind, father's occupation, primary residence before age 16, history of non-suicidal self-injury (NSSI) within the last year, and history of disclosure of suicidal ideation. The XGBoost model showed the highest prediction accuracy (ROC_AUC, 0.72; PR_AUC, 0.65) and sensitivity (0.85) after external validation. The history of NSSI within the last year had the strongest predictive effect on suicide attempts, followed by disclosure of suicidal ideation, sleep quality, BMI z-score, and anxiety levels. CONCLUSIONS: Despite including only 11 easily collectible clinical variables, the XGBoost model effectively identifies suicide attempters among untreated adolescent first-visit MDD patients and performs stably in external validation sets. This is beneficial for clinicians to conduct evidence-based suicide prevention efforts. CI - Copyright (c) 2026 Yuqin Song et al. Depression and Anxiety published by John Wiley & Sons Ltd. FAU - Song, Yuqin AU - Song Y AUID- ORCID: 0009-0004-2685-0078 AD - Mental Health Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, hospital-nsmc.com.cn. AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Dai, Mengqin AU - Dai M AUID- ORCID: 0009-0004-9091-7847 AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Fan, Qiuyue AU - Fan Q AUID- ORCID: 0009-0005-9706-7408 AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Pan, Lu AU - Pan L AUID- ORCID: 0009-0006-3450-7696 AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Wu, Yuhang AU - Wu Y AUID- ORCID: 0009-0003-3364-9906 AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Shao, Jiarui AU - Shao J AUID- ORCID: 0009-0005-0425-5320 AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Lin, Cen AU - Lin C AUID- ORCID: 0009-0009-5229-4286 AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Luo, Wenxiu AU - Luo W AUID- ORCID: 0009-0006-7352-7059 AD - Mental Health Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, hospital-nsmc.com.cn. AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Cen, Yu AU - Cen Y AUID- ORCID: 0009-0004-3917-2069 AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Xie, Cailin AU - Xie C AUID- ORCID: 0009-0004-2787-627X AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. FAU - Wang, Xiangli AU - Wang X AUID- ORCID: 0009-0006-2547-938X AD - Center for Vocational Education Research, Shenzhen University of Information Technology, Shenzhen, Guangdong, China. FAU - Luo, Jiaming AU - Luo J AUID- ORCID: 0000-0003-0025-0379 AD - Mental Health Center, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, China, hospital-nsmc.com.cn. AD - School of Psychiatry, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. AD - Key Laboratory of Digital-Intelligent Disease Surveillance and Health Governance, North Sichuan Medical College, Nanchong, Sichuan, China, nsmc.edu.cn. LA - eng PT - Journal Article PT - Validation Study DEP - 20260227 PL - United States TA - Depress Anxiety JT - Depression and anxiety JID - 9708816 SB - IM MH - Humans MH - *Major Depressive Disorder/psychology MH - *Suicide, Attempted/statistics & numerical data/psychology MH - Female MH - Adolescent MH - Prediction Algorithms MH - Male MH - Classification Algorithms MH - Predictive Learning Models MH - Boosting Machine Learning Algorithms MH - Random Forest PMC - PMC12947665 OTO - NOTNLM OT - adolescents OT - depression OT - machine learning OT - prediction model OT - suicide attempt COIS- The authors declare no conflicts of interest. EDAT- 2026/03/02 13:16 MHDA- 2026/03/08 06:38 PMCR- 2026/02/27 CRDT- 2026/03/02 06:42 PHST- 2025/01/30 00:00 [received] PHST- 2025/11/11 00:00 [revised] PHST- 2025/12/30 00:00 [accepted] PHST- 2026/03/08 06:38 [medline] PHST- 2026/03/02 13:16 [pubmed] PHST- 2026/03/02 06:42 [entrez] PHST- 2026/02/27 00:00 [pmc-release] AID - DA7216497 [pii] AID - 10.1155/da/7216497 [doi] PST - epublish SO - Depress Anxiety. 2026 Feb 27;2026:7216497. doi: 10.1155/da/7216497. eCollection 2026. PMID- 41767782 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260302 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Evaluation of point-of-care hemoglobin testing vs. central laboratory measurements in neonates: a prospective study in neonatal intensive care unit. PG - 1735203 LID - 10.3389/fped.2026.1735203 [doi] LID - 1735203 AB - INTRODUCTION: Point-of-care (POC) testing for blood gas analysis is commonly used for neonates in the Neonatal Intensive Care Unit (NICU) to determine blood gases using small blood volumes. This helps reduce blood loss and speeds up treatment. However, many clinicians remain skeptical about the accuracy of POC hemoglobin results. Our study evaluated the agreement between POC testing and laboratory measurements of hemoglobin concentration in infants born at >28 weeks gestational age. METHODS: This prospective cohort study analyzed 187 paired blood samples from infants born after 28 weeks of gestation admitted to the NICU between July 2023 and December 2024. Hemoglobin levels from paired blood samples were measured using two different Methods: a POC gas analyzer and a laboratory analyzer. The laboratory analyzer (Sysmex XN-9100(R)) requires a minimum of 500 microL of blood, while the POC analyzer (ABL90 Flex Radiometer(R)) only needs 65 microL. A Bland-Altman plot was utilized for statistical analysis to assess the agreement between the two methods and to identify any systematic differences. RESULTS: Of 197 eligible patients, 187 were enrolled in the study, with a mean gestational age of 36.6 weeks (+/- 3.2) at birth. There was no significant difference between the results from laboratory arterial-venous samples (16.14 g/dL) and POC testing (16.04 g/dL; p = 0.34). However, capillary samples from the POC testing showed significantly higher results (p = 0.01) than the laboratory results. The Bland-Altman plot revealed a mean difference of 0.09 for arterial-venous samples and -0.41 for capillary samples when comparing POC results with laboratory results. CONCLUSION: Point-of-care testing for hemoglobin analysis using arterial-venous samples may be an alternative method for quantifying hemoglobin in neonates born at a gestational age >28 weeks. However, due to notable discrepancies between capillary POC results and laboratory results, it is essential to exercise caution when interpreting hemoglobin measurements obtained from capillary POC testing. CI - (c) 2026 Chang, Hou and Maduekwe. FAU - Chang, Vivian AU - Chang V AD - Department of Pediatrics, Neonatology, Stony Brook Children's Hospital, Stony Brook, NY, United States. FAU - Hou, Wei AU - Hou W AD - Family, Population and Preventive Medicine, Stony Brook University Hospital, Stony Brook, NY, United States. FAU - Maduekwe, Echezona T AU - Maduekwe ET AD - Department of Pediatrics, Neonatology, Stony Brook Children's Hospital, Stony Brook, NY, United States. LA - eng PT - Journal Article DEP - 20260212 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC12935908 OTO - NOTNLM OT - blood gas analysis OT - hemoglobin concentration OT - neonatal intensive care OT - neonates OT - point-of-care testing COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/02 13:16 MHDA- 2026/03/02 13:17 PMCR- 2026/02/12 CRDT- 2026/03/02 06:35 PHST- 2025/10/29 00:00 [received] PHST- 2026/01/19 00:00 [revised] PHST- 2026/01/26 00:00 [accepted] PHST- 2026/03/02 13:17 [medline] PHST- 2026/03/02 13:16 [pubmed] PHST- 2026/03/02 06:35 [entrez] PHST- 2026/02/12 00:00 [pmc-release] AID - 10.3389/fped.2026.1735203 [doi] PST - epublish SO - Front Pediatr. 2026 Feb 12;14:1735203. doi: 10.3389/fped.2026.1735203. eCollection 2026. PMID- 41767759 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260302 LR - 20260813 IS - 2673-5059 (Electronic) IS - 2673-5059 (Linking) VI - 7 DP - 2026 TI - Beyond the physical: exploring the complexities of Women's health after severe perineal trauma-a cross-sectional study on predictors of health-related quality of life in Sweden. PG - 1734365 LID - 10.3389/fgwh.2026.1734365 [doi] LID - 1734365 AB - INTRODUCTION: Severe perineal trauma (SPT), defined as third- or fourth-degree lacerations during childbirth, is a known risk factor for adverse postpartum health-related quality of life (HRQoL). Although HRQoL may improve within six months postpartum, up to 30% of affected women in Sweden report long-term health problems beyond one year. While qualitative studies highlight the broad negative impact, quantitative findings remain inconclusive, particularly regarding the role of pelvic floor symptoms and the degree of SPT, underscoring the need for further research. The aim is to assess and compare HRQoL in a sample of women with SPT, and to identify predictors of physical and mental health at least 18 months postpartum. METHODS: A nationwide cross-sectional study was conducted in Sweden using an online questionnaire to assess HRQoL via the validated RAND-36 instrument. Linear regression analysis was employed to explore associations. RESULTS: Two hundred and twenty-one women with SPT and varying symptom bother from SPT, at least 18 months after the childbirth, responded. The study population exhibited worse-than-average RAND-36 scores across most dimensions (apart from physical functioning and pain) compared to normative data for women in Sweden. Further, the mean physical health score was significantly lower in our study sample (M = 70.7, SD = 22.1) compared to the reference population of women in Sweden (M = 73.63, SD = 29.45), t [df (degrees of freedom) 220] = -1.99, p = 0.047, Cohen's d = 0.13. The mean mental health score was significantly lower in our study sample (M = 63.2, SD = 21.4) compared to normative Swedish women (M = 71.7, SD = 27.15), t (df 220) = -5.90, p < 0.001, Cohen's d = 0.40. Health change over the past year remained relatively static with a slight trend towards improvement (mean 54.5; SD 21.6; CI 95% 51.6-57.4). Physical health was predicted by the extent of symptom bother, perceived work ability, educational attainment, and level of physical activity. Mental health was predicted by age, extent of symptom bother, and perceived work ability. CONCLUSIONS: These findings underscore the need for individualized, multidisciplinary care strategies that address both physical and psychological dimensions of recovery after sustaining SPT at childbirth. Future research should investigate the barriers and facilitators influencing HRQoL, to enhance HRQoL and support the reintegration of women with SPT into their social and professional spheres. A deeper understanding of the socioeconomic and occupational contexts of affected women is essential to promote more equitable health outcomes. CI - (c) 2026 Tjernstrom, Lindberg, Wiklund and Persson. FAU - Tjernstrom, Katharina AU - Tjernstrom K AD - Department of Nursing, Umea University, Umea, Sweden. FAU - Lindberg, Inger AU - Lindberg I AD - Department of Nursing, Umea University, Umea, Sweden. FAU - Wiklund, Maria AU - Wiklund M AD - Department of Community Medicine and Rehabilitation, Section of Physiotherapy, Umea University, Umea, Sweden. FAU - Persson, Margareta AU - Persson M AD - Department of Nursing, Umea University, Umea, Sweden. LA - eng PT - Journal Article DEP - 20260212 PL - Switzerland TA - Front Glob Womens Health JT - Frontiers in global women's health JID - 101776281 PMC - PMC12935897 OTO - NOTNLM OT - RAND-36 OT - cross-sectional study OT - health-related quality of life OT - long-term OT - obstetric anal sphincter injury OT - patient-reported outcome measures OT - predictors OT - severe perineal trauma COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/02 13:17 MHDA- 2026/03/02 13:18 PMCR- 2026/02/12 CRDT- 2026/03/02 06:34 PHST- 2025/10/28 00:00 [received] PHST- 2025/12/30 00:00 [revised] PHST- 2026/01/15 00:00 [accepted] PHST- 2026/03/02 13:18 [medline] PHST- 2026/03/02 13:17 [pubmed] PHST- 2026/03/02 06:34 [entrez] PHST- 2026/02/12 00:00 [pmc-release] AID - 10.3389/fgwh.2026.1734365 [doi] PST - epublish SO - Front Glob Womens Health. 2026 Feb 12;7:1734365. doi: 10.3389/fgwh.2026.1734365. eCollection 2026. PMID- 41767011 OWN - NLM STAT- In-Process DCOM- 20260302 LR - 20260828 IS - 1664-2295 (Print) IS - 1664-2295 (Electronic) IS - 1664-2295 (Linking) VI - 17 DP - 2026 TI - The role of pallidotomy in the precision medicine era. PG - 1735969 LID - 10.3389/fneur.2026.1735969 [doi] LID - 1735969 AB - BACKGROUND: The use of radiofrequency pallidotomy (RP) for medically refractory dystonia has markedly declined since the introduction of deep brain stimulation (DBS). Conditions such as severe cognitive impairment, poor nutritional status, or acquired dystonia-common in children with severe dystonia-may limit DBS eligibility or benefit. In these cases, RP may represent a valuable alternative. Evidence on RP in this population remains scarce, mostly based on small case-series with limited follow-up. We retrospectively analyzed RP safety, feasibility and long-term outcomes in children with medically refractory dystonia. METHODS: Records of patients who underwent RP at Bambino Gesu Children's Hospital were reviewed. Outcomes were retrospectively assessed through the Clinical Global Impression-Improvement scale. For patients with a history of status dystonicus (SD), recurrence was used as outcome measure. RESULTS: Eighteen patients underwent 21 procedures. Sixteen received bilateral simultaneous pallidotomy; two unilateral pallidotomy after GPi-DBS removal due to infection. Three patients required repeated surgery for recurrent-SD. Ten had acquired dystonia (cerebral palsy, CP), five genetically confirmed dystonia, three idiopathic dystonia. Three were followed for three months or less; in the others, mean follow-up was 6.62 +/- 3.65 years. Three months postoperatively, 12 of 16 patients improved (1 "very much improved," 2 "much improved," 9 "minimally improved"), 2 were unchanged and 2 minimally worsened. At last follow-up (15 patients), 1 remained "very much improved," 2 "minimally improved," 3 "unchanged," 6"minimally worsened," 3 "much worsened." Among six patients treated for ongoing-SD, crises abated over 50.7 +/- 27.8 days. SD recurred in 8 patients (5 CP, 1 genetic, 2 idiopathic) after a mean of 20.3 +/- 19.8 months. CONCLUSION: RP emerges as a feasible rescue-therapy for severe medically refractory SD. Most patients show meaningful short-term improvement, but beneficial effects tend to decline over time, with high rate of SD recurrence-particularly in dyskinetic-CP. This may reflect suboptimal lesions' location and/or size, progressive disease course or re-emergence of dystonia through different networks. In this light, RP should be considered when DBS is contraindicated, the risk of hardware-related complications outweighs the advantages of an adjustable system, or in patients with limited life expectancy, where an irreversible yet effective rescue intervention is clinically justified. CI - Copyright (c) 2026 Garone, Innocenti, De Benedictis, Rossi-Espagnet, Randi, Lettori, Reali, Frascarelli, Savioli, Cossu, Cantonetti, Infante, Specchio and Marras. FAU - Garone, Giacomo AU - Garone G AD - Neurology, Epilepsy and Movement Disorders Unit, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Innocenti, Alice AU - Innocenti A AD - Neurology, Epilepsy and Movement Disorders Unit, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - De Benedictis, Alessandro AU - De Benedictis A AD - Neurosurgery Unit, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Rossi-Espagnet, Maria Camilla AU - Rossi-Espagnet MC AD - Diagnostic and Interventional Neuroradiology Unit, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Randi, Franco AU - Randi F AD - Neurosurgery Unit, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Lettori, Donatella AU - Lettori D AD - Unit of Neurorehabilitation, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Reali, Simone AU - Reali S AD - Anesthesia and Critical Care Unit, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Frascarelli, Flaminia AU - Frascarelli F AD - Unit of Neurorehabilitation, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Savioli, Alessandra AU - Savioli A AD - Anesthesia and Critical Care Unit, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Cossu, Silvia AU - Cossu S AD - Neurology Unit, Pediatric Hospital Antonio Cao, Brotzu Hospital Trust, Cagliari, Italy. FAU - Cantonetti, Laura AU - Cantonetti L AD - Unit of Neurorehabilitation, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. FAU - Infante, Nazaret AU - Infante N AD - Department of Neurosurgery, Hospital del Mar, Barcelona, Spain. AD - Epilepsy Neuroscience Research Group, Hospital del Mar Research Institute, Barcelona, Spain. FAU - Specchio, Nicola AU - Specchio N AD - Neurology, Epilepsy and Movement Disorders Unit, Bambino Gesu Children's Hospital, IRCCS, Rome, Italy. AD - University Hospitals KU Leuven, Leuven, Belgium. FAU - Marras, Carlo Efisio AU - Marras CE AD - Department of Neurosurgery, Hospital del Mar, Barcelona, Spain. AD - Systems Neurology and Neurotherapeutics Lab Neurosciences Program, Hospital del Mar Research Institute, Barcelona, Spain. LA - eng PT - Journal Article DEP - 20260213 PL - Switzerland TA - Front Neurol JT - Frontiers in neurology JID - 101546899 PMC - PMC12945792 OTO - NOTNLM OT - ablative surgery OT - children OT - dystonia OT - pallidotomy OT - radiofrequency COIS- NS has served on scientific advisory boards for GW Pharma (now Jazz Pharmaceuticals), BioMarin, Arvelle, Marinus, and Takeda; has received speaker honoraria from Eisai, Biomarin, LivaNova, and Sanofi; and has served as an investigator for Zogenix (now a part of UCB), Marinus, Biomarin, UCB, and Roche. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/03/02 13:17 MHDA- 2026/03/02 13:18 PMCR- 2026/02/13 CRDT- 2026/03/02 06:26 PHST- 2025/10/30 00:00 [received] PHST- 2026/01/15 00:00 [revised] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/03/02 13:18 [medline] PHST- 2026/03/02 13:17 [pubmed] PHST- 2026/03/02 06:26 [entrez] PHST- 2026/02/13 00:00 [pmc-release] AID - 10.3389/fneur.2026.1735969 [doi] PST - epublish SO - Front Neurol. 2026 Feb 13;17:1735969. doi: 10.3389/fneur.2026.1735969. eCollection 2026. PMID- 41766783 OWN - NLM STAT- Publisher LR - 20260813 IS - 0972-7531 (Print) IS - 0976-3260 (Electronic) IS - 0972-7531 (Linking) DP - 2026 Feb 26 TI - Design and Validation of an Integrated Intervention Module for Addressing Gaming Addiction Among Adolescents. PG - 09727531251396710 LID - 10.1177/09727531251396710 [doi] LID - 09727531251396710 AB - BACKGROUND: The increasing prevalence of gaming addiction among adolescents has emerged as a growing public health concern, linked to emotional dysregulation, poor academic performance and social withdrawal. Despite its significance, there is a limited availability of structured, school-based psychological intervention protocols specifically targeting this issue. Given the multidimensional nature of gaming addiction, there is a need for evidence-informed, developmentally appropriate modules that integrate emotional, behavioural and cognitive strategies to foster healthier digital engagement in youth. OBJECTIVE: This article outlines the development of a comprehensive behavioural intervention module designed to address the core behavioural and psychological correlates of gaming addiction, reduce symptom severity, sensation seeking, and impulsivity, and promote psychological resilience and well-being in adolescents. MATERIALS AND METHODS: The intervention module was carefully constructed through a comprehensive search of current research and structured in-depth conversations with key stakeholders. These systematic focus group discussions helped ensure that the module played an active role in addressing everyday challenges and was rooted in field-based insights. To evaluate the framework, the module was shared with 10 experts in this discipline. Notably, all 10 subject experts provided valuable input and feedback, helping revise and refine the module. RESULTS: A panel of 10 experts evaluated the module and provided feedback on its content relevance, conceptual clarity, precision, and effectiveness in supporting adolescents with gaming-related concerns. In light of their responses, minimal alterations were made, with most parts of the module being upheld. The mean content validity ratio (CVR) was 0.87, indicating strong consensus among experts on the content's relevance. CONCLUSION: The study validated a structured intervention framework to help manage problematic gaming behaviour and associated traits, such as impulsivity and sensation seeking, with an emphasis on promoting emotional balance and improved well-being. CI - (c) The Author(s) 2026. FAU - L, Smrithi AU - L S AUID- ORCID: 0009-0002-1722-7933 AD - Department of Mind Body Medicine and Lifestyle Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India. FAU - Mathangi, D C AU - Mathangi DC AUID- ORCID: 0000-0002-3148-3792 AD - Department of Mind Body Medicine and Lifestyle Sciences, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India. FAU - Kantipudi, Suvarna Jyothi AU - Kantipudi SJ AUID- ORCID: 0000-0002-9161-3229 AD - Department of Psychiatry, Sri Ramachandra Institute of Higher Education and Research, Chennai, Tamil Nadu, India. LA - eng PT - Journal Article DEP - 20260226 PL - United States TA - Ann Neurosci JT - Annals of neurosciences JID - 101523367 PMC - PMC12945729 OTO - NOTNLM OT - Adolescents OT - behavioural regulation OT - content validation OT - intervention module OT - screen-time management COIS- The authors declared no potential conflicts of interest with respect to the research, authorship and/or publication of this article. EDAT- 2026/03/02 13:17 MHDA- 2026/03/02 13:17 PMCR- 2026/02/26 CRDT- 2026/03/02 06:25 PHST- 2025/10/03 00:00 [received] PHST- 2025/10/25 00:00 [accepted] PHST- 2026/03/02 13:17 [medline] PHST- 2026/03/02 13:17 [pubmed] PHST- 2026/03/02 06:25 [entrez] PHST- 2026/02/26 00:00 [pmc-release] AID - 10.1177_09727531251396710 [pii] AID - 10.1177/09727531251396710 [doi] PST - aheadofprint SO - Ann Neurosci. 2026 Feb 26:09727531251396710. doi: 10.1177/09727531251396710. PMID- 41766600 OWN - NLM STAT- MEDLINE DCOM- 20260713 LR - 20260909 IS - 1550-9109 (Electronic) IS - 0161-8105 (Linking) VI - 49 IP - 7 DP - 2026 Jul 13 TI - Sex differences in sleep disturbances in middle childhood: findings from an urban pediatric cohort study. LID - zsag051 [pii] LID - 10.1093/sleep/zsag051 [doi] AB - STUDY OBJECTIVES: While sleep differs in adult males and females, its variation by sex during childhood is less understood. We examined sex differences in sleep measures in children and explored the influences of selective socio-demographic and health-related factors on these associations. METHODS: The cohort included 323 participants aged 6-12 years who resided predominantly in low-income urban neighborhoods. Sleep duration and maintenance efficiency were assessed using wrist actigraphy. Sleep-disordered breathing (SDB) was assessed from overnight in-home testing. Validated questionnaires assessed sleep-related impairment and sleep disturbance. Linear and logistic regression modeled associations between sex and sleep outcomes, testing for effect modification by demographics, indoor environment, and neighborhood factors. RESULTS: Male children had higher odds for short sleep duration (<8 hours; Odds Ratio [OR] = 1.81, 95% confidence interval [CI] = 1.06, 3.08) and low sleep efficiency (<85%; OR = 2.04, 95% CI = 1.24, 3.35), which persisted after adjusting for health-related factors. Male sex was associated with a 17.4% higher geometric mean of SDB respiratory event frequency (p < .05). Effect modification analysis showed stronger associations between male sex and lower sleep efficiency for children older than 10 years, between male sex and short sleep duration for minority children, and between male sex and SDB for children of mothers with lower education. No sex differences were observed in parent-reported sleep outcomes. CONCLUSIONS: Male children were at higher risk for several objectively measured but not for caregiver-reported sleep outcomes; findings were unexplained by common health problems. Risk appeared further elevated in males who were older than 10 years and were of minority ethno-racial background or from homes with low maternal education. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Sleep Research Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Zhao, Shuangyu AU - Zhao S AUID- ORCID: 0000-0003-0454-872X AD - Department of Nutrition, University of California, Davis, CA, United States. FAU - Wang, Jing AU - Wang J AD - Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States. AD - Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Gueye-Ndiaye, Seyni AU - Gueye-Ndiaye S AD - Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States. AD - Division of Pulmonary and Sleep Medicine, Boston Children's Hospital, Boston, MA, United States. FAU - Li, Xiaoyu AU - Li X AUID- ORCID: 0000-0002-4463-9944 AD - Department of Sociology, Tsinghua University, Beijing, China. FAU - Owens, Judith AU - Owens J AD - Division of Neurology, Boston Children's Hospital, Boston, MA, United States. FAU - Gold, Diane R AU - Gold DR AD - Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, United States. AD - Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA, United States. FAU - Chen, Jarvis T AU - Chen JT AD - Department of Social and Behavioral Sciences, Harvard T.H. Chan School of Public Health, Boston, MA, United States. FAU - Phipatanakul, Wanda AU - Phipatanakul W AUID- ORCID: 0000-0001-8639-0473 AD - Division of Pulmonary and Sleep Medicine, Boston Children's Hospital, Boston, MA, United States. AD - Division of Allergy and Immunology, Boston Children's Hospital, Boston, MA, United States. FAU - Redline, Susan AU - Redline S AUID- ORCID: 0000-0002-6585-1610 AD - Division of Sleep and Circadian Disorders, Brigham and Women's Hospital, Boston, MA, United States. LA - eng GR - K24AI106822/National Institute Health/ GR - P30ES000002/National Institute Health/ GR - R35HL135818/National Institute Health/ GR - L40HL165622/National Institute Health/ GR - R01HL137192/National Institute Health/ PT - Journal Article PL - United States TA - Sleep JT - Sleep JID - 7809084 SB - IM CIN - Sleep. 2026 Sep 9;49(9):zsag106. doi: 10.1093/sleep/zsag106. PMID: 41995259 MH - Humans MH - Child MH - Male MH - Female MH - Sleep Duration MH - Cohort Studies MH - *Sleep Wake Disorders/epidemiology MH - *Urban Population/statistics & numerical data MH - Actigraphy MH - Sex Factors MH - Surveys and Questionnaires MH - Sleep Apnea Syndromes/epidemiology MH - *Sex Characteristics OTO - NOTNLM OT - low sleep efficiency OT - pediatric health OT - sex differences OT - short sleep duration OT - sleep-disordered breathing EDAT- 2026/03/02 07:55 MHDA- 2026/07/13 06:32 CRDT- 2026/03/02 05:42 PHST- 2025/07/02 00:00 [received] PHST- 2026/02/05 00:00 [revised] PHST- 2026/02/06 00:00 [accepted] PHST- 2026/07/13 06:32 [medline] PHST- 2026/03/02 07:55 [pubmed] PHST- 2026/03/02 05:42 [entrez] AID - 8503339 [pii] AID - 10.1093/sleep/zsag051 [doi] PST - ppublish SO - Sleep. 2026 Jul 13;49(7):zsag051. doi: 10.1093/sleep/zsag051. PMID- 41766524 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260822 IS - 1463-1326 (Electronic) IS - 1462-8902 (Linking) VI - 28 IP - 5 DP - 2026 May TI - The 1-Hour Plasma Glucose for Early Risk Stratification in Young, Obese Chinese Adults: Implications for Clinical Management. PG - 4276-4285 LID - 10.1111/dom.70620 [doi] AB - AIMS: To evaluate the impact of applying the International Diabetes Federation (IDF) 1-hour plasma glucose (1h-PG) criteria on diagnosing dysglycaemia in young Chinese adults with obesity, and to validate the metabolic basis and diagnostic performance of these criteria in this high-risk population. METHODS: This Cross-Sectional Study Included 2484 Obese Individuals (Aged 18-40 Years, BMI >/= 28 kg/m(2)). Participants underwent a 75-g oral glucose tolerance test (OGTT). Glycaemic status was classified using both traditional American Diabetes Association (ADA) criteria (fasting and 2-hour PG) and the IDF criteria (1h-PG cutoffs: 8.6 mmol/L for intermediate hyperglycaemia, 11.6 mmol/L for diabetes). Insulin sensitivity, secretion and beta-cell function indices were calculated. Reclassification patterns were assessed, and the diagnostic accuracy of the 1h-PG cutoffs was evaluated using receiver operating characteristic (ROC) curve analysis against the ADA criteria. RESULTS: Applying IDF criteria doubled the prevalence of diabetes (from 12.0% to 22.7%) and significantly increased total dysglycaemia. This newly identified dysglycaemic population exhibited an intermediate metabolic phenotype with worsening insulin resistance and impaired early-phase beta-cell function. ROC analysis demonstrated excellent diagnostic accuracy for the IDF diabetes cutoff (11.6 mmol/L; AUC 0.927), which matched the population-optimal cutoff. The cutoff for intermediate hyperglycaemia (8.6 mmol/L) showed high sensitivity (86.8%) for detecting ADA-defined prediabetes. CONCLUSIONS: The IDF 1h-PG criteria uncover a substantial, previously unrecognised burden of dysglycaemia in young Chinese adults with obesity, supported by clear metabolic defects and strong diagnostic performance. These findings support the use of 1h-PG as a practical tool for earlier risk stratification in this vulnerable population. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Yuan, Miaomiao AU - Yuan M AUID- ORCID: 0000-0002-8322-4776 AD - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai, China. FAU - Zhang, Zhenxi AU - Zhang Z AUID- ORCID: 0009-0008-3334-8704 AD - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai, China. FAU - Chen, Yufei AU - Chen Y AUID- ORCID: 0000-0003-4023-2861 AD - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai, China. FAU - Lu, Chenxiao AU - Lu C AUID- ORCID: 0000-0002-1888-7194 AD - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai, China. FAU - Shen, Chongrong AU - Shen C AUID- ORCID: 0000-0001-7164-3888 AD - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai, China. FAU - Zhao, Shaoqian AU - Zhao S AUID- ORCID: 0009-0000-7701-5305 AD - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai, China. FAU - Hong, Jie AU - Hong J AUID- ORCID: 0000-0003-4250-3004 AD - Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Shanghai, China. LA - eng GR - 25ZR1402341/Natural Science Foundation of Shanghai Municipality/ GR - 25ZR1402352/Natural Science Foundation of Shanghai Municipality/ GR - SHDC12024109/Shanghai Municipal Hospital Development Center/ GR - 82070863/Data Center of Management Science, National Natural Science Foundation of China - Peking University/ GR - 82370845/Data Center of Management Science, National Natural Science Foundation of China - Peking University/ GR - 2025M782163/China Postdoctoral Science Foundation/ GR - 2025ZD0552000/National Health Commission of the People's Republic of China/ PT - Journal Article DEP - 20260302 PL - England TA - Diabetes Obes Metab JT - Diabetes, obesity & metabolism JID - 100883645 RN - 0 (Blood Glucose) RN - Chinese people SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - *Blood Glucose/metabolism/analysis MH - China/epidemiology MH - Cross-Sectional Studies MH - *Diabetes Mellitus, Type 2/epidemiology/blood/diagnosis MH - Glucose Tolerance Test MH - Insulin Resistance MH - Insulin-Secreting Cells MH - *Obesity/complications/blood MH - *Prediabetic State/diagnosis/blood/epidemiology MH - Risk Assessment MH - Risk Factors MH - East Asian People OTO - NOTNLM OT - 1-hour plasma glucose OT - Chinese population OT - diagnostic criteria OT - insulin resistance OT - international diabetes federation (IDF) OT - obesity OT - oral glucose tolerance test (OGTT) OT - type 2 diabetes OT - young adults OT - beta-Cell function EDAT- 2026/03/02 07:55 MHDA- 2026/04/13 06:32 CRDT- 2026/03/02 04:54 PHST- 2026/02/16 00:00 [revised] PHST- 2026/02/02 00:00 [received] PHST- 2026/02/17 00:00 [accepted] PHST- 2026/04/13 06:32 [medline] PHST- 2026/03/02 07:55 [pubmed] PHST- 2026/03/02 04:54 [entrez] AID - 10.1111/dom.70620 [doi] PST - ppublish SO - Diabetes Obes Metab. 2026 May;28(5):4276-4285. doi: 10.1111/dom.70620. Epub 2026 Mar 2. PMID- 41765049 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 1872-7697 (Electronic) IS - 0167-8760 (Linking) VI - 223 DP - 2026 May TI - Test-retest reliability of time- and frequency-domain measures of short-term resting heart rate variability in a healthy young population. PG - 113341 LID - S0167-8760(26)00023-1 [pii] LID - 10.1016/j.ijpsycho.2026.113341 [doi] AB - Heart rate variability (HRV), the difference in time between successive heart beats, is gaining in popularity among researchers because it is thought to be an effective index of parasympathetic activity. As such, HRV has been associated with individual traits related to mental, emotional, social and physical health outcomes. As it is being used more often as a reflection of relatively stable individual traits, the measurement of HRV's stability was investigated on three time points (T1, T2, T3). A total of 116 participants (i.e., 80 at all time points; 96 at T1 and T2, 89 at T1 and T3, 91 at T2 and T3) completed a survey to assess confounding variables (e.g., sleep quality, exercise behavior, contraceptive use, and consumption of food, recreational drugs, and alcohol) and engaged in a 7-minute seated rest HRV recording to observe ln-RMSSD, HF(peak), ln-HF, and HF(nu). The intraclass correlation coefficients (ICCs) revealed strong correlations for ln-RMSSD and ln-HF.(.) Reliability analyses were significant but moderate for HF(nu) and poor for HF(peak). The measures best thought to reflect vagal tone (RMSSD and ln-HF) did show strong reliability supporting the use of these parameters as a consistent trait-like quality of an individual. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - North, Jonathan R AU - North JR AD - Department of Health & Kinesiology, University of Illinois at Urbana-Champaign, 906 S Goodwin Ave, Urbana, IL, 61801, United States of America. FAU - Adamek, John F AU - Adamek JF AD - Department of Health & Kinesiology, University of Illinois at Urbana-Champaign, 906 S Goodwin Ave, Urbana, IL, 61801, United States of America. FAU - Markowitz, Erin N AU - Markowitz EN AD - Department of Health & Kinesiology, University of Illinois at Urbana-Champaign, 906 S Goodwin Ave, Urbana, IL, 61801, United States of America; Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, IL, 60515, United States of America. FAU - Petruzzello, Steven J AU - Petruzzello SJ AD - Department of Health & Kinesiology, University of Illinois at Urbana-Champaign, 906 S Goodwin Ave, Urbana, IL, 61801, United States of America. Electronic address: petruzze@illinois.edu. LA - eng PT - Journal Article DEP - 20260228 PL - Netherlands TA - Int J Psychophysiol JT - International journal of psychophysiology : official journal of the International Organization of Psychophysiology JID - 8406214 SB - IM MH - Humans MH - *Heart Rate/physiology MH - Female MH - Male MH - Reproducibility of Results MH - Young Adult MH - Adult MH - *Rest/physiology MH - Electrocardiography MH - Adolescent MH - Time Factors OTO - NOTNLM OT - Heart rate variability OT - Parasympathetic nervous system OT - Stability EDAT- 2026/03/02 00:38 MHDA- 2026/04/03 00:31 CRDT- 2026/03/01 19:10 PHST- 2025/08/26 00:00 [received] PHST- 2026/02/09 00:00 [revised] PHST- 2026/02/11 00:00 [accepted] PHST- 2026/04/03 00:31 [medline] PHST- 2026/03/02 00:38 [pubmed] PHST- 2026/03/01 19:10 [entrez] AID - S0167-8760(26)00023-1 [pii] AID - 10.1016/j.ijpsycho.2026.113341 [doi] PST - ppublish SO - Int J Psychophysiol. 2026 May;223:113341. doi: 10.1016/j.ijpsycho.2026.113341. Epub 2026 Feb 28. PMID- 41764983 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 1872-9126 (Electronic) IS - 0003-6870 (Linking) VI - 135 DP - 2026 Sep TI - Generating a representative anthropometric dataset for U.S. children and youth. PG - 104764 LID - S0003-6870(26)00042-6 [pii] LID - 10.1016/j.apergo.2026.104764 [doi] AB - Anthropometric data are widely used in the design of products and environments for children, but the associated publicly available data are sparse and challenging to use. In the United States, the ongoing National Health and Nutrition Examination Survey (NHANES) collects data for both adults and children, including a small number of anthropometric measures. NHANES provides the only available data from which national estimates of U.S. anthropometric variables can be made, but the sampling structure necessitates the use of sample weights to compute estimates. Moreover, a relatively small amount of data is available for children and youth, considering that estimates are often needed for narrow age cohorts. As a result, published estimates are often missing values, particularly in the lower and upper percentiles where many design decisions are made. To address the needs of practitioners, we present and validate a method for synthesizing an unweighted anthropometric dataset for U.S. children and youth ages 2 through 19 years. The method generates continuous models of the distribution of stature, body weight, and body mass index (BMI) by age and sex. Comparison with the published non-parametric quantiles for 2015-2018 shows excellent agreement for all three measures. The resulting synthesized dataset can be used as the foundation for weighting or synthesizing detailed datasets for use in design and provides an avenue for continually updating detailed datasets as NHANES releases new data. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Parkinson, Matthew B AU - Parkinson MB AD - Penn State University, University Park, PA, USA. Electronic address: parkinson@psu.edu. FAU - Reed, Matthew P AU - Reed MP AD - University of Michigan Transportation Research Institute, Ann Arbor, MI, USA. LA - eng PT - Journal Article DEP - 20260228 PL - England TA - Appl Ergon JT - Applied ergonomics JID - 0261412 SB - IM MH - Humans MH - Child MH - United States MH - Adolescent MH - Nutrition Surveys MH - Child, Preschool MH - *Anthropometry/methods MH - Female MH - Body Height MH - Body Mass Index MH - Body Weight MH - Male MH - Young Adult MH - *Datasets as Topic OTO - NOTNLM OT - Anthropometry OT - Children OT - Design OT - Design for human variability OT - NHANES OT - Reweighting OT - Weighting COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/02 00:38 MHDA- 2026/04/12 18:29 CRDT- 2026/03/01 18:06 PHST- 2025/05/17 00:00 [received] PHST- 2025/10/21 00:00 [revised] PHST- 2026/02/27 00:00 [accepted] PHST- 2026/04/12 18:29 [medline] PHST- 2026/03/02 00:38 [pubmed] PHST- 2026/03/01 18:06 [entrez] AID - S0003-6870(26)00042-6 [pii] AID - 10.1016/j.apergo.2026.104764 [doi] PST - ppublish SO - Appl Ergon. 2026 Sep;135:104764. doi: 10.1016/j.apergo.2026.104764. Epub 2026 Feb 28. PMID- 41764881 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 1873-5711 (Electronic) IS - 1050-6411 (Linking) VI - 87 DP - 2026 Apr TI - Accelerometric decoding of upper extremity movement intention in children with and without cerebral palsy: Complementary value of mechanomyography. PG - 103126 LID - S1050-6411(26)00022-2 [pii] LID - 10.1016/j.jelekin.2026.103126 [doi] AB - Children with movement disorders often interact with their environment via targeted upper extremity movement. However, due to athetosis or dystonia, these gestural intentions can become variable and unpredictable. While accelerometry has been used for hyperkinetic movement analysis in cerebral palsy (CP), decoding movement intention remains challenging due to variability. In this multiple case study, we investigated the potential of detecting movement intention using six tri-axial accelerometers positioned over the biceps brachii long head, triceps brachii long head, flexor carpi radialis, extensor carpi radialis longus, anterior deltoid, and pectoralis major muscles to capture both limb motion and mechanomyographic (MMG) activity. Fifteen typically developing (TD) children and three children with CP performed a tablet-based drawing task involving discrete, self-paced linear motions. Hidden Markov model-based classification revealed that integrating MMG with motion signals improved recognition accuracy. The combined approach achieved 88.0 +/- 5.6% quaternary classification accuracy in TD children. A similar quaternary recognition rate was achieved for one of the participants with movement disorders. Average participant-specific accuracies exceeded 70% for all three participants with CP when considering the differentiation between pairs of movements based on combined motion and MMG signals. These findings underscore the potential of MMG for movement intention decoding, informing assistive technology development for motor-impaired individuals. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Correa, Marcela AU - Correa M AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Road, Toronto M4G 1R8, Ontario, Canada; Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto M5S 3G9, Ontario, Canada. FAU - Samadani, Ali AU - Samadani A AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Road, Toronto M4G 1R8, Ontario, Canada; Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto M5S 3G9, Ontario, Canada. FAU - de Holanda, Ledycnarf J AU - de Holanda LJ AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Road, Toronto M4G 1R8, Ontario, Canada; Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto M5S 3G9, Ontario, Canada. FAU - Corky, Yara AU - Corky Y AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Road, Toronto M4G 1R8, Ontario, Canada; Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto M5S 3G9, Ontario, Canada. FAU - Chau, Tom AU - Chau T AD - Bloorview Research Institute, Holland Bloorview Kids Rehabilitation Hospital, 150 Kilgour Road, Toronto M4G 1R8, Ontario, Canada; Institute of Biomedical Engineering, University of Toronto, 164 College Street, Toronto M5S 3G9, Ontario, Canada. Electronic address: tchau@hollandbloorview.ca. LA - eng PT - Journal Article DEP - 20260225 PL - England TA - J Electromyogr Kinesiol JT - Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology JID - 9109125 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology MH - Child MH - Movement MH - Female MH - Male MH - *Myography/methods MH - *Accelerometry/methods MH - *Upper Extremity/physiopathology MH - Sensitivity and Specificity MH - Reproducibility of Results MH - *Intention MH - *Muscle, Skeletal/physiopathology MH - *Actigraphy/methods OTO - NOTNLM OT - Cerebral palsy OT - Decoding of movement intention OT - Hidden Markov model OT - Mechanomyography COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/02 00:38 MHDA- 2026/03/12 01:09 CRDT- 2026/03/01 18:04 PHST- 2025/06/30 00:00 [received] PHST- 2026/01/28 00:00 [revised] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/03/12 01:09 [medline] PHST- 2026/03/02 00:38 [pubmed] PHST- 2026/03/01 18:04 [entrez] AID - S1050-6411(26)00022-2 [pii] AID - 10.1016/j.jelekin.2026.103126 [doi] PST - ppublish SO - J Electromyogr Kinesiol. 2026 Apr;87:103126. doi: 10.1016/j.jelekin.2026.103126. Epub 2026 Feb 25. PMID- 41764759 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 1108-7161 (Print) IS - 1108-7161 (Linking) VI - 26 IP - 1 DP - 2026 Mar 1 TI - Clinical Features in Children with Persistent Toe Walking Who Carry Heterozygous PYGM Variants: A Cross-Sectional Study. PG - 115-123 AB - OBJECTIVES: Persistent toe walking (TW) in children is often idiopathic but may conceal subtle neuromuscular or metabolic causes. This cross-sectional, retrospective study investigated clinical and genetic characteristics of children carrying PYGM variants to explore potential subclinical phenotypes among heterozygous carriers. METHODS: Seventy-two (72) children meeting criteria for idiopathic TW were evaluated using a standardized clinical protocol and a validated 49-gene next-generation sequencing neuromuscular panel. Variants were classified as pathogenic, likely pathogenic, or of uncertain significance according to ACMG/AMP guidelines. Analyses were descriptive. RESULTS: Among 1,300 screened patients, 72 were identified as PYGM variant carriers. Toe walking was bilateral in all cases, with severe dorsiflexion restriction (/=2.0). Clinicopathological characteristics, transplant outcomes, and graft survival were evaluated across the groups. RESULTS: Recipient age showed a significant inverse correlation with the BSAR (r = -0.750; P < .001). BSAR-high KT were associated with enhanced glomerular filtration rates post-transplant, without significant different graft survival rates in comparison to BSAR-mid KT. Recipients of kidney graft from relatively smaller donors (BSAR-low) showed a trend towards a higher rate of perioperative complications and a significantly higher rate of graft loss compared to BSAR-mid KT (P = .021). Multivariate Cox regression analysis could confirm BSAR-low as an independent risk factor of decreased graft survival (adjusted HR 3.741; P = .008). CONCLUSION: Our findings suggest that KTs from relatively larger donors (BSAR-high) are safe and perform comparably to size-matched grafts (BSAR-mid) in pediatric recipients, while smaller donor kidneys (BSAR-low) may carry a higher risk of intraoperative complications and reduced graft survival. Further large-scale studies are needed to validate these observations. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Scheuermann, Uwe AU - Scheuermann U AD - Department of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of Leipzig, Leipzig, Germany. Electronic address: uwe.scheuermann@medizin.uni-leipzig.de. FAU - Seiffer, Sophie AU - Seiffer S AD - Department of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of Leipzig, Leipzig, Germany. FAU - Dittrich, Katalin AU - Dittrich K AD - Department of Pediatrics, Pediatric Nephrology, University Hospital of Leipzig, Leipzig, Germany. FAU - Siekmeyer, Manuela AU - Siekmeyer M AD - Department of Pediatrics, Pediatric Nephrology, University Hospital of Leipzig, Leipzig, Germany. FAU - Meyer, Hans-Jonas AU - Meyer HJ AD - Department of Diagnostic and Interventional Radiology, University of Leipzig, Leipzig, Germany. FAU - Rhode, Philipp AU - Rhode P AD - Department of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of Leipzig, Leipzig, Germany. FAU - Unruh, Julia AU - Unruh J AD - Department of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of Leipzig, Leipzig, Germany. FAU - Haak, Fabian AU - Haak F AD - Department of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of Leipzig, Leipzig, Germany. FAU - Seehofer, Daniel AU - Seehofer D AD - Department of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of Leipzig, Leipzig, Germany. FAU - Tautenhahn, Hans-Michael AU - Tautenhahn HM AD - Department of Visceral, Transplantation, Vascular and Thoracic Surgery, University Hospital of Leipzig, Leipzig, Germany. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260227 PL - United States TA - Transplant Proc JT - Transplantation proceedings JID - 0243532 SB - IM MH - *Body Surface Area MH - *Kidney Transplantation/adverse effects/methods MH - *Graft Survival MH - *Tissue Donors MH - *Transplant Recipients MH - Treatment Outcome MH - Prognosis MH - Retrospective Studies MH - Glomerular Filtration Rate MH - Intraoperative Complications/epidemiology MH - Humans MH - Male MH - Female MH - Child MH - Adolescent MH - Follow-Up Studies MH - Prospective Studies MH - Infant MH - Child, Preschool MH - Young Adult MH - Adult MH - Middle Aged COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/03/01 00:35 MHDA- 2026/03/26 01:03 CRDT- 2026/02/28 21:52 PHST- 2025/09/28 00:00 [received] PHST- 2026/02/17 00:00 [accepted] PHST- 2026/03/26 01:03 [medline] PHST- 2026/03/01 00:35 [pubmed] PHST- 2026/02/28 21:52 [entrez] AID - S0041-1345(26)00110-7 [pii] AID - 10.1016/j.transproceed.2026.02.016 [doi] PST - ppublish SO - Transplant Proc. 2026 Apr;58(3):482-487. doi: 10.1016/j.transproceed.2026.02.016. Epub 2026 Feb 27. PMID- 41763242 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260804 IS - 2049-4408 (Electronic) IS - 2049-4394 (Linking) VI - 108-B IP - 3 DP - 2026 Mar 1 TI - Supervised versus self-managed rehabilitation for patients with an acute first-time or recurrent patellar dislocation: the Physiotherapy Rehabilitation Post Patellar Dislocation (PRePPeD) external pilot randomized controlled trial and embedded qualitative study. PG - 310-321 LID - 10.1302/0301-620X.108B3.BJJ-2025-0403.R1 [doi] AB - AIMS: The aim of this study was to determine the feasibility of a full-scale randomized controlled trial (RCT) comparing two exercise-based rehabilitation interventions for patients with an acute patellar dislocation. METHODS: A two-group external pilot RCT and embedded qualitative study was conducted in five English NHS hospitals. Patients were aged >/= 14 years with an acute (recruited /= 60 defining msSDB. Multivariable regression models were used to identify dietary associations. A dietary prediction score was developed and its performance assessed using receiver operating characteristic (ROC) analysis, followed by external validation in a separate cohort (n = 24). RESULTS: Among 406 participants (mean [SD] age, 8.0 [2.1] years; 174 girls [42.9%]), 80 children (19.7%) had msSDB. Higher intake of orange juice, sweets, chocolate, rice, and processed meats was significantly associated with greater total OSA-18 scores and worse subscale scores across domains. Conversely, fish for dinner and savory snacks were inversely associated with symptom burden. A dietary prediction model demonstrated acceptable discrimination for msSDB (area under the ROC curve [AUC] = 0.78; 95% CI, 0.72-0.84). The model showed 79.6% accuracy, 56.3% sensitivity, and 85.3% specificity, with comparable performance in the validation cohort. CONCLUSIONS: Specific dietary behaviors are associated with SDB symptom severity in children. A simple dietary-based score can help identify children at risk for clinically significant SDB, supporting the investigation of dietary interventions in pediatric SDB management. CI - (c) 2026. The Author(s). FAU - Chuang, Hai-Hua AU - Chuang HH AUID- ORCID: 0000-0002-7394-4016 AD - School of Medicine, College of Life Science and Medicine, National Tsing Hua University, Hsinchu, Taiwan. AD - Department of Community Medicine, Cathay General Hospital, Taipei, Taiwan. AD - Department of Industrial Engineering and Management, National Taipei University of Technology, Taipei, Taiwan. FAU - Hu, Ruei-Shan AU - Hu RS AD - Department of Otorhinolaryngology-Head and Neck Surgery, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Lin, Wan-Ni AU - Lin WN AUID- ORCID: 0000-0001-5782-8835 AD - Department of Otorhinolaryngology-Head and Neck Surgery, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Hsin, Li-Jen AU - Hsin LJ AUID- ORCID: 0000-0001-9201-0270 AD - Department of Otorhinolaryngology-Head and Neck Surgery, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Fang, Tuan-Jen AU - Fang TJ AUID- ORCID: 0000-0002-8762-3635 AD - Department of Otorhinolaryngology-Head and Neck Surgery, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Li, Hsueh-Yu AU - Li HY AUID- ORCID: 0000-0002-9016-8098 AD - Department of Otorhinolaryngology-Head and Neck Surgery, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. FAU - Lee, Li-Ang AU - Lee LA AUID- ORCID: 0000-0001-8414-595X AD - School of Medicine, College of Life Science and Medicine, National Tsing Hua University, Hsinchu, Taiwan. 5738@cgmh.org.tw. AD - Department of Otorhinolaryngology-Head and Neck Surgery, Linkou Main Branch, Chang Gung Memorial Hospital, Taoyuan, Taiwan. 5738@cgmh.org.tw. AD - School of Medicine, College of Medicine, Chang Gung University, Taoyuan, Taiwan. 5738@cgmh.org.tw. AD - Department of Otorhinolaryngology-Head and Neck Surgery, Linkou Medical Center, Chang Gung Memorial Hospital, No. 5, Fu-Hsing Street, Gueishan District,, Taoyuan City, 33305, Taiwan. 5738@cgmh.org.tw. LA - eng PT - Journal Article DEP - 20260228 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 SB - IM MH - Humans MH - Female MH - Male MH - Child MH - Cross-Sectional Studies MH - Taiwan/epidemiology MH - *Sleep Apnea Syndromes/epidemiology MH - Surveys and Questionnaires MH - *Diet/adverse effects MH - Child, Preschool MH - *Feeding Behavior MH - Risk Factors MH - Severity of Illness Index MH - Quality of Life MH - ROC Curve MH - Body Mass Index MH - Prevalence PMC - PMC12950093 OTO - NOTNLM OT - Child OT - Dietary behavior OT - Nutrition OT - Prediction model OT - Quality of life OT - Sleep-disordered breathing COIS- Declarations. Competing interests: The authors declare that they have no conflict of interest. Generative AI and AI-assisted technologies in the writing process: During the preparation of this work, the authors used Gemini 3 Pro in order to perform grammatical and spelling checks. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication. EDAT- 2026/02/28 12:53 MHDA- 2026/03/06 09:07 PMCR- 2026/02/28 CRDT- 2026/02/28 11:24 PHST- 2025/08/29 00:00 [received] PHST- 2026/01/31 00:00 [accepted] PHST- 2026/03/06 09:07 [medline] PHST- 2026/02/28 12:53 [pubmed] PHST- 2026/02/28 11:24 [entrez] PHST- 2026/02/28 00:00 [pmc-release] AID - 10.1007/s00394-026-03921-z [pii] AID - 3921 [pii] AID - 10.1007/s00394-026-03921-z [doi] PST - epublish SO - Eur J Nutr. 2026 Feb 28;65(2):73. doi: 10.1007/s00394-026-03921-z. PMID- 41761480 OWN - NLM STAT- MEDLINE DCOM- 20260725 LR - 20260725 IS - 1875-9270 (Electronic) IS - 1051-9815 (Linking) VI - 84 IP - 4 DP - 2026 Aug TI - Ergonomics knowledge, awareness, and behaviors in a clinical setting: Comparison of individuals with musculoskeletal pain and healthy volunteers. PG - 1016-1023 LID - 10.1177/10519815261424804 [doi] AB - BackgroundErgonomics plays a critical role in musculoskeletal health, yet validated tools such as ROSA may be impractical in high-demand clinical settings. This study compared ergonomics knowledge, awareness, and behaviors between individuals with and without musculoskeletal pain using a concise yes/no-based tool.ObjectiveTo compare ergonomic behaviors, knowledge, and awareness between individuals with and without musculoskeletal pain, and to identify behavioral factors associated with chronic pain.MethodsA cross-sectional study was conducted among adults aged 18-65 in a tertiary healthcare facility. Participants completed a binary-response ergonomics questionnaire assessing posture, workstation adjustment, screen use, and ergonomic equipment habits. Group comparisons used Chi-square and Mann-Whitney U tests (p < 0.05).ResultsAmong 222 participants, chronic pain was significantly associated with female gender, being a housewife, poor posture, lack of chair height adjustment, and reduced screen-time awareness. (p < 0.05) Correct posture, chair adjustment, and screen-time awareness were protective. Elbow support use was associated with lower chronic pain prevalence (p = 0.033).ConclusionsA rapid, binary ergonomics assessment effectively identified behavioral risk factors for chronic musculoskeletal pain. This format may support scalable ergonomic screening in diverse occupational environments. FAU - Kuculmez, Ozlem AU - Kuculmez O AUID- ORCID: 0000-0002-8900-0060 AD - Department of Physical Medicine and Rehabilitation, Baskent University Alanya Hospital, Antalya, Turkey. FAU - Sukun, Abdullah AU - Sukun A AUID- ORCID: 0000-0003-0047-0857 AD - Department of Radiology, Baskent University Alanya Hospital, Antalya, Turkey. LA - eng PT - Journal Article DEP - 20260227 PL - United States TA - Work JT - Work (Reading, Mass.) JID - 9204382 SB - IM MH - Humans MH - Female MH - Adult MH - *Ergonomics/methods/standards MH - *Musculoskeletal Pain/psychology/epidemiology MH - Male MH - Cross-Sectional Studies MH - Middle Aged MH - Surveys and Questionnaires MH - Adolescent MH - Posture MH - *Health Knowledge, Attitudes, Practice MH - Young Adult MH - Aged MH - Working Conditions MH - Risk Factors MH - *Awareness OTO - NOTNLM OT - chronic pain OT - ergonomics OT - musculoskeletal diseases OT - occupational health OT - pain management OT - posture OT - rehabilitation COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/02/28 06:34 MHDA- 2026/07/25 06:36 CRDT- 2026/02/28 00:52 PHST- 2026/07/25 06:36 [medline] PHST- 2026/02/28 06:34 [pubmed] PHST- 2026/02/28 00:52 [entrez] AID - 10.1177/10519815261424804 [doi] PST - ppublish SO - Work. 2026 Aug;84(4):1016-1023. doi: 10.1177/10519815261424804. Epub 2026 Feb 27. PMID- 41760385 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260812 IS - 1473-0480 (Electronic) IS - 0306-3674 (Linking) VI - 60 IP - 8 DP - 2026 Mar 31 TI - Association of leisure-time physical activity at different phases of life with work ability at the end of working life: a Finland-representative 45-year prospective cohort study. PG - 583-589 LID - 10.1136/bjsports-2025-110339 [doi] AB - OBJECTIVE: Leisure-time physical activity (LTPA) has been linked to better work ability in cross-sectional and short-term follow-up studies. Less is known about the effects of long-term habitual LTPA on work ability. We investigated whether differences in lifetime LTPA from adolescence to late adulthood affect work ability at the end of working life. METHODS: In this 45-year observational cohort study involving a nationally representative Finnish sample, we created a latent lifetime LTPA factor from three self-report PA measurements at ages 10-19, 35-44 and 55-64 years. The association between the lifetime LTPA factor and validated Work Ability Index at the end of working life (age 55-64 years) was explored with structural equation modelling-based linear regression analysis. RESULTS: Higher lifetime LTPA was associated with higher work ability at the end of working life (N=2385, 45% males; ss=0.22, SE=0.05, p<0.001) while all three LTPA measurements contributed to the latent LTPA factor (adolescence ss=0.29, SE=0.05; mid-adulthood ss=0.40, SE=0.06; late adulthood LTPA ss=0.59, SE=0.09). In late adulthood (N=815), meeting the 2020 WHO PA guidelines was dose-responsively associated with excellent work ability: OR very active (>2.38 metabolic equivalent of task (MET)-hour/day (>300 min moderate-to-vigorous PA (MVPA) or >150 min vigorous PA (VPA)/week) vs inactive (<1.19 MET-hour/day (<150 min MVPA or <75 min of VPA/week)) = 2.18, 95% CI 1.44 to 3.30; OR active (1.19-2.38 MET-hour/day (150-300 min MVPA or 75-150 min VPA/week)) vs inactive=1.67, 95% CI 1.04 to 2.68. The results remained unchanged after adjustment for covariates sex, educational level and work-related physical strain. CONCLUSIONS: An inactive lifestyle adopted in youth and maintained throughout life may present a significant risk for impaired work ability up to the end of working life. To support workforce productivity, it is essential to implement robust strategies that promote PA, particularly among children and adolescents, but also among working age adults. CI - (c) Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Laakso, Perttu AU - Laakso P AUID- ORCID: 0000-0002-6320-8437 AD - University of Jyvaskyla, Faculty of Sport and Health Sciences, Jyvaskyla, Finland perttu.t.t.laakso@jyu.fi. FAU - Ortega, Francisco B AU - Ortega FB AUID- ORCID: 0000-0003-2001-1121 AD - University of Jyvaskyla, Faculty of Sport and Health Sciences, Jyvaskyla, Finland. AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada; and CIBEROBN Physiopathology of Obesity and Nutrition; Granada, Spain, University of Granada, Granada, Spain. FAU - Tolvanen, Asko AU - Tolvanen A AUID- ORCID: 0000-0001-6430-8897 AD - University of Jyvaskyla, Faculty of Education and Psychology, Jyvaskyla, Finland. FAU - Jaakkola, Timo AU - Jaakkola T AUID- ORCID: 0000-0003-1227-2460 AD - University of Jyvaskyla, Faculty of Sport and Health Sciences, Jyvaskyla, Finland. LA - eng PT - Journal Article PT - Observational Study DEP - 20260331 PL - England TA - Br J Sports Med JT - British journal of sports medicine JID - 0432520 SB - IM MH - Humans MH - Finland MH - *Leisure Activities MH - Male MH - Middle Aged MH - Female MH - Prospective Studies MH - *Exercise MH - Adult MH - Child MH - Adolescent MH - Young Adult MH - *Work Capacity Evaluation OTO - NOTNLM OT - Cohort Studies OT - Longitudinal Studies OT - Physical activity OT - Public health COIS- Competing interests: None declared. EDAT- 2026/02/28 00:41 MHDA- 2026/04/01 00:29 CRDT- 2026/02/27 21:42 PHST- 2026/02/12 00:00 [accepted] PHST- 2026/04/01 00:29 [medline] PHST- 2026/02/28 00:41 [pubmed] PHST- 2026/02/27 21:42 [entrez] AID - bjsports-2025-110339 [pii] AID - 10.1136/bjsports-2025-110339 [doi] PST - epublish SO - Br J Sports Med. 2026 Mar 31;60(8):583-589. doi: 10.1136/bjsports-2025-110339. PMID- 41759887 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 1873-2399 (Electronic) IS - 0301-472X (Linking) VI - 157 DP - 2026 May TI - Gremlin-1 promotes leukemic survival via PI3K/AKT signaling in infant MLL-AF4-positive B-cell acute lymphoblastic leukemia. PG - 105402 LID - S0301-472X(26)00035-4 [pii] LID - 10.1016/j.exphem.2026.105402 [doi] AB - Infant B-cell acute lymphoblastic leukemia (B-ALL) harboring the KMT2A-AFF1 (MLL-AF4) fusion is associated with aggressive clinical behavior and poor outcomes, yet the molecular regulators that sustain leukemic cell survival in this high-risk subtype remain incompletely defined. In this study, we analyzed public transcriptomic data sets to identify genes selectively upregulated in MLL-AF4-positive infant B-ALL and identified gremlin-1 (GREM1) as a candidate survival-associated factor. GREM1 expression was validated in primary leukemic blasts and cell lines at both the mRNA and protein levels. Functional assays showed that recombinant GREM1 enhanced leukemic cell viability, whereas GREM1 neutralization or knockdown increased cell death, as assessed by cell viability assays and 7-AAD staining. Mechanistically, GREM1 promoted activation of the PI3K/AKT signaling pathway, and genetic inhibition of PIK3CA attenuated GREM1-mediated survival effects. In a xenograft model based on pretreated leukemia cells, GREM1 neutralization reduced leukemic fitness and was associated with a survival benefit trend. Clinically, elevated GREM1 expression was associated with inferior overall and event-free survival in independent patient cohorts. Together, these findings identify GREM1 as a leukemia cell-associated regulator of survival in infant MLL-AF4-positive B-ALL and implicate PI3K/AKT signaling as a key downstream mediator, suggesting that GREM1-associated survival pathways may represent a potential vulnerability in this aggressive leukemia subtype. CI - Copyright (c) 2026 International Society for Experimental Hematology. Published by Elsevier Inc. All rights reserved. FAU - Liu, Xiaotian AU - Liu X AD - Department of Anesthesiology, Children's Hospital of Soochow University, Suzhou, China. FAU - Zhang, Youjian AU - Zhang Y AD - Department of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, China. FAU - Hua, Shenghao AU - Hua S AD - Department of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, China. FAU - Shao, Xuejun AU - Shao X AD - Department of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, China. Electronic address: xjshao@suda.edu.cn. FAU - Yin, Lei AU - Yin L AD - Department of Clinical Laboratory, Children's Hospital of Soochow University, Suzhou, China. Electronic address: yinl1882@163.com. LA - eng PT - Journal Article DEP - 20260225 PL - Netherlands TA - Exp Hematol JT - Experimental hematology JID - 0402313 RN - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt) RN - 0 (Oncogene Proteins, Fusion) RN - EC 2.7.1.- (Phosphatidylinositol 3-Kinases) RN - 149025-06-9 (Myeloid-Lymphoid Leukemia Protein) RN - 0 (MLL-AF4 fusion protein, human) RN - 0 (GREM1 protein, human) RN - 0 (Intercellular Signaling Peptides and Proteins) SB - IM MH - Humans MH - *Signal Transduction MH - *Proto-Oncogene Proteins c-akt/metabolism/genetics MH - Animals MH - *Oncogene Proteins, Fusion/genetics/metabolism MH - *Phosphatidylinositol 3-Kinases/metabolism MH - *Myeloid-Lymphoid Leukemia Protein/genetics/metabolism MH - *Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/metabolism/genetics/pathology/mortality MH - Infant MH - Cell Survival MH - Mice MH - Gene Expression Regulation, Leukemic MH - Cell Line, Tumor MH - Female MH - Intercellular Signaling Peptides and Proteins COIS- Declaration of competing interest The authors do not have any conflicts of interest to declare in relation to this work. EDAT- 2026/02/28 00:41 MHDA- 2026/04/27 00:30 CRDT- 2026/02/27 19:15 PHST- 2025/09/28 00:00 [received] PHST- 2026/02/14 00:00 [revised] PHST- 2026/02/16 00:00 [accepted] PHST- 2026/04/27 00:30 [medline] PHST- 2026/02/28 00:41 [pubmed] PHST- 2026/02/27 19:15 [entrez] AID - S0301-472X(26)00035-4 [pii] AID - 10.1016/j.exphem.2026.105402 [doi] PST - ppublish SO - Exp Hematol. 2026 May;157:105402. doi: 10.1016/j.exphem.2026.105402. Epub 2026 Feb 25. PMID- 41759590 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260718 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 222 DP - 2026 Jul 1 TI - Examining social and family contextual differences between parental feeding practice profiles in UK parents of pre-school children. PG - 108516 LID - S0195-6663(26)00078-4 [pii] LID - 10.1016/j.appet.2026.108516 [doi] AB - Prior research has utilised person-centred approaches to identify parent feeding profiles distinguished by controlling and structure-based practices, but less research has examined autonomy support-based practices, or how social and family contextual factors differ between feeding profiles. This study aimed to identify profiles of parents with similar patterns of feeding practices and to examine whether profiles differ on family contextual factors. In 2022, 989 UK parents of children aged 3-6 years (M = 4.1 years) completed an online survey, which included the Comprehensive Feeding Practices Questionnaire (CFPQ), measuring parental feeding practices, and validated questionnaires capturing family contextual variables. Latent Profile Analysis (LPA) was conducted to identify parent feeding profiles using the CFPQ. A MANCOVA assessed differences in family contextual variables between profiles. LPA identified three profiles based on common model fit indices and theoretical considerations. Profile 1 'moderate control' (25.2%) showed moderate use of controlling practices and low use of structure-based and autonomy support-based practices. Profile 2 'structured and supportive' (29.6%) showed low use of controlling practices and high use of structure-based and autonomy support-based practices. Profile 3 'using everything' (45.2%) showed high use of all three types of feeding practices. Parents in the 'moderate control' profile had significantly lower parental wellbeing and reported more barriers of time and energy for meal planning compared to other profiles. In contrast, parents in the 'structured and supportive' profile had significantly lower household chaos and lower parental stress. Mothers had a higher proportion of membership to the 'structured and supportive' profile (33.9%) compared to other profiles, whereas fathers had a higher membership proportion to the 'using everything' profile (60.9%). Future interventions should be tailored to parent feeding practice profiles and associated family contextual factors. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Povall, Hannah AU - Povall H AD - School of Psychology and Institute of Health and Neurodevelopment, Aston University, Birmingham, B4 7ET, UK; Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, 3220, Australia. Electronic address: hpova16@aston.ac.uk. FAU - Blissett, Jacqueline AU - Blissett J AD - School of Psychology and Institute of Health and Neurodevelopment, Aston University, Birmingham, B4 7ET, UK. FAU - Pickard, Abigail AU - Pickard A AD - School of Psychology and Institute of Health and Neurodevelopment, Aston University, Birmingham, B4 7ET, UK; Department of Clinical Psychology, School of Health in Social Science, University of Edinburgh, UK. FAU - Edwards, Katie L AU - Edwards KL AD - School of Psychology and Institute of Health and Neurodevelopment, Aston University, Birmingham, B4 7ET, UK; School of Psychology, University of Birmingham, UK. FAU - Russell, Catherine G AU - Russell CG AD - Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, 3220, Australia. FAU - Lacy, Kathleen AU - Lacy K AD - Institute for Physical Activity and Nutrition (IPAN), School of Exercise and Nutrition Sciences, Deakin University, Geelong, VIC, 3220, Australia. FAU - Farrow, Claire AU - Farrow C AD - School of Psychology and Institute of Health and Neurodevelopment, Aston University, Birmingham, B4 7ET, UK. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260226 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Male MH - United Kingdom MH - Child, Preschool MH - Surveys and Questionnaires MH - *Feeding Behavior/psychology MH - *Parents/psychology MH - *Parenting/psychology MH - Child MH - Adult MH - Parent-Child Relations OTO - NOTNLM OT - Feeding goals OT - Latent profile analysis OT - Parent feeding practices OT - Parental stress OT - Parental wellbeing OT - Preschool children COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/02/28 00:41 MHDA- 2026/05/08 00:32 CRDT- 2026/02/27 19:11 PHST- 2025/11/26 00:00 [received] PHST- 2026/02/13 00:00 [revised] PHST- 2026/02/25 00:00 [accepted] PHST- 2026/05/08 00:32 [medline] PHST- 2026/02/28 00:41 [pubmed] PHST- 2026/02/27 19:11 [entrez] AID - S0195-6663(26)00078-4 [pii] AID - 10.1016/j.appet.2026.108516 [doi] PST - ppublish SO - Appetite. 2026 Jul 1;222:108516. doi: 10.1016/j.appet.2026.108516. Epub 2026 Feb 26. PMID- 41759241 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260709 IS - 1532-1983 (Electronic) IS - 0261-5614 (Linking) VI - 59 DP - 2026 Apr TI - Breastfed infants receiving formula supplementation show altered lipid and gut microbiota profiles at 3 months of age. PG - 106602 LID - S0261-5614(26)00029-4 [pii] LID - 10.1016/j.clnu.2026.106602 [doi] AB - BACKGROUND & AIMS: Exclusive breastfeeding offers numerous health benefits. Despite advancements in formula, significant differences compared with breast milk remain. We aimed to assess how milk feeding type and volume at 3 months affect the infant plasma lipidome and gut microbiota. METHODS: Infants were classified into exclusive breastfeeding (EBF), mixed feeding (MF), or exclusive formula feeding (EFF) groups based on feeding data collected prospectively across two European cohorts (n = 519). Lipidomics and shotgun metagenomics were applied to plasma and stool samples, respectively. RESULTS: Feeding type explained major variation in both lipidomic and microbial profiles. Plasma lipids showed distinct signatures across groups, particularly in sphingomyelins and diacylglycerols. Microbiota diversity and species richness increased with formula exposure. Formula rich in intact whey protein was linked to higher S. thermophilus abundance in the infant gut. Random forest classification of feeding type using either lipidomic or gut microbiota features achieved high discriminatory accuracy (AUROC >0.90) in training and validation datasets. CONCLUSION: Early nutrition is a critical determinant of the lipidome and gut microbiome during the breastfeeding phase. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Myers, Pernille Neve AU - Myers PN AD - Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark; Cmbio A/S, Copenhagen, Denmark. FAU - van Beijsterveldt, Inge A L P AU - van Beijsterveldt IALP AD - Department of Pediatrics, Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, the Netherlands. FAU - Snowden, Stuart G AU - Snowden SG AD - Core Metabolomics and Lipidomics Laboratory, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom; Department of Biological Sciences, Royal Holloway University of London, United Kingdom. FAU - Eriksen, Carsten AU - Eriksen C AD - Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. FAU - Nielsen, Henrik Bjorn AU - Nielsen HB AD - Cmbio A/S, Copenhagen, Denmark. FAU - Hughes, Ieuan A AU - Hughes IA AD - Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom. FAU - Ong, Ken K AU - Ong KK AD - Department of Paediatrics, University of Cambridge, Cambridge, United Kingdom; Medical Research Council Epidemiology Unit, University of Cambridge, Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge, United Kingdom. FAU - Hokken-Koelega, Anita C S AU - Hokken-Koelega ACS AD - Department of Pediatrics, Erasmus MC Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, the Netherlands. FAU - Koulman, Albert AU - Koulman A AD - Core Metabolomics and Lipidomics Laboratory, Metabolic Research Laboratories, Institute of Metabolic Science, University of Cambridge, Cambridge, United Kingdom. Electronic address: ak675@medschl.cam.ac.uk. FAU - Brix, Susanne AU - Brix S AD - Department of Biotechnology and Biomedicine, Technical University of Denmark, Kongens Lyngby, Denmark. Electronic address: sbrix@dtu.dk. LA - eng PT - Journal Article DEP - 20260218 PL - England TA - Clin Nutr JT - Clinical nutrition (Edinburgh, Scotland) JID - 8309603 RN - 0 (Lipids) SB - IM MH - Humans MH - *Breast Feeding MH - Infant MH - *Infant Formula MH - Female MH - *Gastrointestinal Microbiome/physiology MH - Lipidomics MH - *Lipids/blood MH - Feces/microbiology MH - Male MH - *Dietary Supplements MH - Infant Nutritional Physiological Phenomena MH - Prospective Studies OTO - NOTNLM OT - Breastfeeding OT - Infant nutrition OT - Lipidomics OT - Microbiome COIS- Conflict of interest The authors all declare no conflict of interest. EDAT- 2026/02/27 19:31 MHDA- 2026/03/29 07:35 CRDT- 2026/02/27 17:59 PHST- 2025/10/22 00:00 [received] PHST- 2026/02/10 00:00 [revised] PHST- 2026/02/13 00:00 [accepted] PHST- 2026/03/29 07:35 [medline] PHST- 2026/02/27 19:31 [pubmed] PHST- 2026/02/27 17:59 [entrez] AID - S0261-5614(26)00029-4 [pii] AID - 10.1016/j.clnu.2026.106602 [doi] PST - ppublish SO - Clin Nutr. 2026 Apr;59:106602. doi: 10.1016/j.clnu.2026.106602. Epub 2026 Feb 18. PMID- 41759230 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260723 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 88 DP - 2026 May-Jun TI - Impact of combined intradialytic exercise on quality of life, functional capacity, and dialysis adequacy in pediatric hemodialysis patients: A pilot study. PG - 140-147 LID - S0882-5963(26)00093-X [pii] LID - 10.1016/j.pedn.2026.02.023 [doi] AB - BACKGROUND: Pediatric patients with chronic kidney disease (CKD) undergoing maintenance hemodialysis frequently exhibit compromised physical performance and reduced quality of life (QoL). The present study aimed to examine the effects of an eight-week combined intradialytic exercise intervention on QoL, functional capacity, and dialysis adequacy, defined as an index of urea clearance efficiency during hemodialysis, in this patient population. METHOD: In a quasi-experimental, one-group, before-and-after trial, five children (aged 8-18 years) with CKD on maintenance hemodialysis completed an eight-week intervention. The program, conducted three times a week during dialysis, consisted of upper-body resistance exercises (two sets of 10 repetitions at the 10-repetition maximum) and aerobic cycling (10-15 min, with intensity monitored via the Children's OMNI Scale). Outcomes included QoL (Pediatric Quality of Life Inventory [PedsQL] 4.0, child and parent reports), functional capacity (handgrip strength and 60-s sit-to-stand [STS60] tests), and dialysis adequacy (single-pool Kt/V). RESULTS: Child-reported PedsQL scores significantly improved for total QoL (Deltax̄= 6.80, 95% CI [1.01, 12.58], p = 0.031, d = 1.46), emotional functioning (p = 0.043, d = 1.30), and social functioning (p = 0.042, d = 1.32). Handgrip strength (Deltax̄= 2.20 kg, 95% CI [1.25, 3.14], p = 0.003, d = 2.90) and STS60 performance (Deltax̄= 2.80 repetitions, 95% CI [0.57, 5.02], p = 0.025, d = 1.56) also increased significantly. CONCLUSION: Combined intradialytic exercise significantly enhanced child-reported QoL and functional capacity in pediatric hemodialysis patients, particularly in emotional, social, and physical domains. These findings support the feasibility and efficacy of combined intradialytic exercise as an adjunct therapy for children with CKD. IMPLICATIONS TO PRACTICE: This 8-week pilot study showed that combined intradialytic exercise upper-body resistance training (2 sets of 10 reps at 10RM) with aerobic cycling (10-15 min at an intensity of 3-5 on the Children's OMNI Scale), performed 3 times/week at the start of hemodialysis significantly improved child-reported quality of life, handgrip strength, and lower-body function. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Ghorbani-Khosroshahi, Reza AU - Ghorbani-Khosroshahi R AD - Department of Exercise Physiology, Faculty of Sport Sciences and Health, University of Tehran, Tehran, IRAN. FAU - Kordi, Mohammad Reza AU - Kordi MR AD - Department of Exercise Physiology, Faculty of Sport Sciences and Health, University of Tehran, Tehran, IRAN. Electronic address: mrkordi@ut.ac.ir. FAU - Saffar Kohneh Quchan, Amir Hossein AU - Saffar Kohneh Quchan AH AD - Department of Exercise Physiology, Faculty of Sport Sciences and Health, University of Tehran, Tehran, IRAN. Electronic address: amirsaffar@ut.ac.ir. FAU - Sedeh, Rozhin Barati AU - Sedeh RB AD - Department of Exercise Physiology, Faculty of Sport Sciences and Health, University of Tehran, Tehran, IRAN. FAU - Mohkam, Masoumeh AU - Mohkam M AD - Department of Pediatrics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IRAN. FAU - Ghorbani-Khosroshahi, Neda AU - Ghorbani-Khosroshahi N AD - Department of Pediatrics, School of Medicine, Children Medical Research & Training Hospital, Tabriz University of Medical Sciences. FAU - Babaee, Marzieh AU - Babaee M AD - Physical Medicine and Rehabilitation Department, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, IRAN. LA - eng PT - Journal Article DEP - 20260226 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM EIN - J Pediatr Nurs. 2026 Sep-Oct;90:846. doi: 10.1016/j.pedn.2026.07.013. PMID: 42493257 MH - Humans MH - *Quality of Life MH - Child MH - *Renal Dialysis/methods MH - Pilot Projects MH - Male MH - Adolescent MH - Female MH - *Kidney Failure, Chronic/therapy/diagnosis MH - *Exercise Therapy/methods MH - Treatment Outcome MH - Hand Strength MH - Resistance Training/methods MH - *Renal Insufficiency, Chronic/therapy OTO - NOTNLM OT - Child OT - Exercise therapy OT - Hemodialysis OT - Kidney failure, chronic OT - Muscle strength OT - Quality of life COIS- Declaration of competing interest The authors declare no conflicts of interest. No financial or non-financial relationships exist that could be perceived to influence the objectivity of the research presented in this manuscript. EDAT- 2026/02/27 19:32 MHDA- 2026/05/09 00:33 CRDT- 2026/02/27 17:59 PHST- 2025/08/04 00:00 [received] PHST- 2026/02/18 00:00 [revised] PHST- 2026/02/19 00:00 [accepted] PHST- 2026/05/09 00:33 [medline] PHST- 2026/02/27 19:32 [pubmed] PHST- 2026/02/27 17:59 [entrez] AID - S0882-5963(26)00093-X [pii] AID - 10.1016/j.pedn.2026.02.023 [doi] PST - ppublish SO - J Pediatr Nurs. 2026 May-Jun;88:140-147. doi: 10.1016/j.pedn.2026.02.023. Epub 2026 Feb 26. PMID- 41758477 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260227 LR - 20260813 IS - 2199-1170 (Print) IS - 2198-9761 (Electronic) IS - 2198-9761 (Linking) VI - 12 IP - 1 DP - 2026 Feb 27 TI - Handgrip Strength Reference Values and Compositional Associations with Physical Activity in Early Childhood: A Large Sample Study of Swedish Preschoolers. LID - 10.1186/s40798-026-00992-4 [doi] LID - 19 AB - BACKGROUND: Muscular strength is a marker of current health and a predictor of long-term health outcomes in young populations, supporting the inclusion of muscle-strengthening activities into current guidelines and recommendations. Over the last decade, muscular strength has been included in several fitness-test batteries in children and adolescents. However, little is known about its relevance and the feasibility of assessing it in preschool children aged 3-5 years. Therefore, in this cross-sectional study, we aimed to generate reference values for handgrip strength in Swedish preschool children and to examine the associations of device-measured movement behaviours (sedentary time [ST], light physical activity [LPA], moderate-to-vigorous physical activity [MVPA], and sleep duration) with handgrip strength using compositional data analysis. RESULTS: A total of 3,218 preschool children (48.53% female) aged 3.0-5.5 years from Sweden were included. Handgrip strength was measured using a validated analog dynamometer following standardized procedures. Movement behaviours were assessed in a subsample of 2,328 children who had both handgrip data and valid accelerometer recordings. Compositional data analysis was used to examine associations between handgrip strength and the 24-hour time-use composition, adjusting for age, sex, body mass index, parental education, and wear time. Age- and sex-specific percentiles for handgrip strength were developed. Boys showed higher handgrip values than girls at all ages (e.g., median increased from 4.08 to 7.42 kg in boys and from 3.45 to 6.87 kg in girls between ages 3 and 5 years). When the proportion of time spent in MVPA increased relative to the other behaviours, handgrip strength rose by + 1.22 kg; the opposite was observed for ST, which related to - 0.84 kg lower handgrip strength. No significant associations were observed for LPA or sleep duration (LPA: beta =-0.48 kg, 95% CI: -1.23, 0.27; sleep: beta = 0.10 kg, 95% CI: -0.37, 0.57). CONCLUSION: This study provides the first normative reference values for handgrip strength from Northern Europe. These values offer a useful reference for screening and contextual interpretation of muscular strength in preschool children. CI - (c) 2026. The Author(s). FAU - Ramirez-Osuna, Ana AU - Ramirez-Osuna A AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, Granada, Spain. FAU - Campos-Garzon, Pablo AU - Campos-Garzon P AUID- ORCID: 0000-0003-0418-9165 AD - Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. pablo.campos.garzon@ki.se. AD - Faculty of Health Sciences, University of Lethbridge, Lethbridge, AB, Canada. pablo.campos.garzon@ki.se. FAU - Huertas-Delgado, Francisco Javier AU - Huertas-Delgado FJ AD - "La Inmaculada" Teacher Training Centre, University of Granada, Granada, 18013, Spain. FAU - Ahlqvist, Viktor H AU - Ahlqvist VH AD - Department of Biomedicine, Aarhus University, Aarhus, Denmark. AD - Institute of Environmental Medicine, Karolinska Insitutet, Stockholm, Sweden. FAU - Wilen, Charlotte AU - Wilen C AD - Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. FAU - Henriksson, Pontus AU - Henriksson P AD - Department of Medical and Health Sciences, Linkoping University, Linkoping, 581 83, Sweden. FAU - Lundberg, Tommy R AU - Lundberg TR AD - Department of Medical and Health Sciences, Linkoping University, Linkoping, 581 83, Sweden. AD - Division of Clinical Physiology, Department of Laboratory Medicine, Karolinska Institute, Stockholm, Sweden. FAU - Neovius, Martin AU - Neovius M AD - Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. FAU - Dahlen, Micael AU - Dahlen M AD - Centre for Epidemiology and Community Medicine, Region Stockholm, Stockholm, Sweden. FAU - Berglind, Daniel AU - Berglind D AD - Department of Global Public Health, Karolinska Institutet, Stockholm, Sweden. AD - Unit of Clinical Physiology, Karolinska University Hospital, Stockholm, Sweden. AD - Centre for Epidemiology and Community Medicine, Region Stockholm, Stockholm, Sweden. LA - eng PT - Journal Article DEP - 20260227 PL - Switzerland TA - Sports Med Open JT - Sports medicine - open JID - 101662568 PMC - PMC12949204 OTO - NOTNLM OT - Muscular strength OT - Physical fitness OT - Preschoolers OT - Reference values COIS- Declarations. Ethics Approval and Consent to Participate: Ethical approval was obtained from the Swedish Ethical Review Authority (Dnr. 2020-03002). The study was conducted in accordance with the ethical standards outlined in the Declaration of Helsinki. Written informed consent was obtained from the parents or legal guardians of all participating children and from participating preschool teachers prior to enrollment in the study. Consent for Publication: Not applicable. Competing Interests: The authors declare that they have no competing interests. EDAT- 2026/02/27 13:05 MHDA- 2026/02/27 13:06 PMCR- 2026/02/27 CRDT- 2026/02/27 11:17 PHST- 2025/08/27 00:00 [received] PHST- 2026/02/17 00:00 [accepted] PHST- 2026/02/27 13:06 [medline] PHST- 2026/02/27 13:05 [pubmed] PHST- 2026/02/27 11:17 [entrez] PHST- 2026/02/27 00:00 [pmc-release] AID - 10.1186/s40798-026-00992-4 [pii] AID - 992 [pii] AID - 10.1186/s40798-026-00992-4 [doi] PST - epublish SO - Sports Med Open. 2026 Feb 27;12(1):19. doi: 10.1186/s40798-026-00992-4. PMID- 41758461 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20261010 IS - 1179-1926 (Electronic) IS - 0312-5963 (Linking) VI - 65 IP - 5 DP - 2026 May TI - Predicting Cumulative Neonatal Sodium Benzoate Exposures During Breastfeeding with Physiologically Based Pharmacokinetic Modelling. PG - 665-680 LID - 10.1007/s40262-026-01624-6 [doi] AB - BACKGROUND AND OBJECTIVE: Sodium benzoate (SB) is used as a second-line therapy to treat rare urea cycle disorders (UCDs) in paediatric and adult patients. However, lactation data for SB do not exist, leading to uncertainties regarding the extent of infant drug exposure due to breastfeeding while taking this medication. These uncertainties may lead to cessation of breastfeeding, unnecessarily depriving both mother and infant of its numerous benefits. Thus, this study aims to develop and apply a paediatric physiologically based pharmacokinetic (PBPK) model to predict the compounded neonatal SB exposure from both in utero and from breastfeeding. METHODS: An adult whole-body PBPK model for SB was first developed and validated with literature-based plasma concentrations after oral or intravenous doses. To account for age-related changes in SB pharmacokinetics, the adult model was scaled to paediatric populations using age-dependent algorithms to capture physiological and anatomical changes, while ontogeny functions were developed to capture maturation of enzymes and transporters where possible. A published cord-coupled PBPK modelling workflow was followed to simulate the cumulative pre- and post-natal drug exposure levels in breastfed infants, accounting for variability in milk ingestion volumes and assuming a conservative milk-to-plasma ratio of 1:1. The upper area under the curve (AUC) ratio (UAR) was used for risk assessment, taking the ratio between the AUC for the highest risk (95(th) percentile simulated AUC) infants and the median maternal AUC following a therapeutic SB dose and multiplying by 100% to report as a percentage. RESULTS: The paediatric PBPK model captured observed SB plasma concentrations in both neonates and children with acceptable bias and precision, supported by the average-fold error (AFE: 1.17) and the absolute AFE (AAFE: 1.24) evaluation metrics, respectively. Neonatal SB exposure levels were the highest on the first day of life (UAR: 14.2%) due to the presence of residual prenatal drug levels. Subsequent UAR values were low (1.5-3.3%) on postnatal days 1-31, suggesting rapid neonatal clearance and negligible contribution of prenatal exposure relative to breastfeeding exposure for the infant's total drug burden. CONCLUSION: This study is the first to report a paediatric PBPK model of SB pharmaceutical use, incorporating prenatal and lactational exposure to assess the cumulative risk of exposure for the breastfed infant. Model predictions suggest that SB exposure through breastfeeding is minimal and unlikely to cause adverse outcomes when compared with clinical studies. These findings may support clinical decision making in the absence of clinical lactation data; however, empirical studies are needed to validate the predictions given the limited information on milk transfer, enzyme ontogeny, and neonatal concentrations. CI - (c) 2026. The Author(s), under exclusive licence to Springer Nature Switzerland AG. FAU - Wang, Shirley AU - Wang S AD - School of Pharmacy, University of Waterloo, Kitchener, ON, Canada. FAU - Hamadeh, Abdullah AU - Hamadeh A AD - School of Pharmacy, University of Waterloo, Kitchener, ON, Canada. FAU - Mian, Paola AU - Mian P AD - Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, 9713 GZ, Groningen, The Netherlands. AD - Department of Paediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. FAU - Edginton, Andrea N AU - Edginton AN AUID- ORCID: 0000-0002-9014-1653 AD - School of Pharmacy, University of Waterloo, Kitchener, ON, Canada. aedginto@uwaterloo.ca. LA - eng PT - Journal Article DEP - 20260227 PL - Switzerland TA - Clin Pharmacokinet JT - Clinical pharmacokinetics JID - 7606849 RN - OJ245FE5EU (Sodium Benzoate) SB - IM MH - Humans MH - Infant, Newborn MH - *Breast Feeding MH - *Models, Biological MH - Female MH - *Sodium Benzoate/pharmacokinetics/administration & dosage/blood MH - Adult MH - Infant MH - Milk, Human/chemistry/metabolism MH - Pregnancy COIS- Declarations. Conflicts of Interest: ANE is an Editorial Board member of Clinical Pharmacokinetics. ANE was not involved in the selection of peer reviewers for the manuscript nor any of the subsequent editorial decisions. All remaining authors (SW, AH, and PM) have declared no conflicts of interest. Data Availability Statement: The data used for model development and validation may be found in Tables 1 and 2. Ethics Approval: The original studies reporting sodium benzoate clinical PK data were Institutional Review Board-approved and no new enrolments occurred for this research. Consent to Participate: Informed consent and assent, if applicable, were obtained from all participants of the original studies which took part in collecting the sodium benzoate data. Consent for Publication: Not applicable. Code Availability: The open-source platforms by Open Systems Pharmacology, PK-Sim(R) and Mobi(R) were used. Authors' Contributions: SW: conceptualisation, methodology, data acquisition, scripting, data analysis and interpretation, high-quality figures, and manuscript preparation. AH: scripting, critical revisions of the manuscript. PM: supervision and critical revision of the manuscript. ANE: conceptualisation, supervision, critical revisions of the manuscript. All authors approved the final version of the manuscript. EDAT- 2026/02/27 13:05 MHDA- 2026/05/19 00:28 CRDT- 2026/02/27 11:17 PHST- 2025/09/02 00:00 [received] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/05/19 00:28 [medline] PHST- 2026/02/27 13:05 [pubmed] PHST- 2026/02/27 11:17 [entrez] AID - 10.1007/s40262-026-01624-6 [pii] AID - 10.1007/s40262-026-01624-6 [doi] PST - ppublish SO - Clin Pharmacokinet. 2026 May;65(5):665-680. doi: 10.1007/s40262-026-01624-6. Epub 2026 Feb 27. PMID- 41758431 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2196-1042 (Electronic) IS - 1723-7785 (Print) IS - 1723-7785 (Linking) VI - 27 IP - 1 DP - 2026 Feb 27 TI - Reliability of AI-driven cephalometric analysis on CBCT: comparison with manual 2D cephalometry. LID - 10.1186/s40510-026-00613-6 [doi] LID - 8 AB - BACKGROUND: Artificial intelligence (AI) is increasingly utilized in orthodontics to automate cephalometric analysis. Despite promising results for AI-based landmark detection on 2D cephalograms, the reliability of AI analyses performed on 3D CBCT data by commercial systems remains unclear. The aim of this study was to evaluate the interchangeability between the results of AI-driven cephalometric analyses using two commercial software platforms (CephX and Invivo) on CBCT datasets and reference 2D cephalometric analysis following manual landmark identification. MATERIALS AND METHODS: This retrospective study included 135 patients (mean age: 26.8 +/- 10.1 years) who underwent concurrent CBCT and lateral cephalometric imaging. Analyses (Steiner and Ricketts methods) based on manual landmark identification served as the reference standard. For each variable, the mean difference (AI - reference) with 95% confidence intervals (CIs) and Bland-Altman plots were calculated. The intrareader repeatability of the manual reference was assessed with the ICC (3). For clinical interpretability, commonly accepted bands (angles +/- 1-2 degrees , linear +/- 2 mm) were used. RESULTS: Both AI systems showed systematic bias for key skeletal and dental measures. For CephX, SNA differed by + 3.40 degrees (95% CI + 1.66 to + 5.14), SNB by + 5.88 degrees (+ 4.33 to + 7.43), and ANB by - 2.48 degrees (- 4.38 to - 0.58). For Invivo, SNA was + 5.07 degrees (+ 2.40 to + 7.74), the SNB was + 4.40 degrees (+ 2.64 to + 6.16), and the ANB was + 5.55 degrees (+ 0.77 to + 10.33). Many parameters also had wide limits of agreement, indicating poor precision for individual patients. Several variables suggested proportional bias (greater discrepancy at larger values). The intrareader ICCs for the manual reference were 0.91-0.95. Overall, the 95% CIs for sentinel angles commonly exceed +/- 2 degrees , which argues against clinical interchangeability. CONCLUSIONS: In their current form, the evaluated AI CBCT cephalometry tools do not match manual 2D cephalometry closely enough for standalone clinical use. Differences of 3-6 degrees in the core sagittal angles are large enough to change the diagnosis and treatment plans. AI outputs should be reviewed and, when necessary, corrected by clinicians. CI - (c) 2026. The Author(s). FAU - Kazimierczak, Natalia AU - Kazimierczak N AD - Kazimierczak Clinic, Bydgoszcz, Poland. FAU - Chwarscianek, Natalia AU - Chwarscianek N AD - Ludwik Rydygier Provincial Hospital, Torun, Poland. FAU - Sultani, Nora AU - Sultani N AD - Faculty of Medicine, Collegium Medicum, Nicolaus Copernicus University, Torun, Poland. FAU - Janiszewska-Olszowska, Joanna AU - Janiszewska-Olszowska J AD - Department of Interdisciplinary Dentistry, Pomeranian Medical University, Szczecin, Poland. FAU - Jankowski, Tomasz AU - Jankowski T AD - Private Dental Practice Jankowscy Clinic, Zary, Poland. FAU - Nowicka, Anita AU - Nowicka A AD - Kazimierczak Clinic, Bydgoszcz, Poland. FAU - Serafin, Zbigniew AU - Serafin Z AD - Faculty of Medicine, Bydgoszcz University of Science and Technology, Bydgoszcz, Poland. FAU - Kazimierczak, Wojciech AU - Kazimierczak W AD - Department of Radiology and Diagnostic Imaging, Collegium Medicum, Nicolaus Copernicus University, Torun, Poland. w.kazimierczak@cm.umk.pl. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260227 PL - Germany TA - Prog Orthod JT - Progress in orthodontics JID - 100936353 SB - IM MH - Humans MH - *Cephalometry/methods MH - *Cone-Beam Computed Tomography/methods MH - Retrospective Studies MH - Reproducibility of Results MH - *Artificial Intelligence MH - Anatomic Landmarks/diagnostic imaging MH - Female MH - Adult MH - Software MH - Male MH - Imaging, Three-Dimensional MH - Young Adult MH - Intelligent Systems MH - Adolescent PMC - PMC12949154 OTO - NOTNLM OT - Artificial intelligence OT - CBCT OT - CephX OT - Cephalometric analysis OT - Intraclass correlation coefficient OT - Invivo OT - Orthodontic diagnosis COIS- Declarations. Ethics approval and consent to participate: This retrospective study was conducted in accordance with the principles of the Declaration of Helsinki and was approved by the Ethics Committee of anonymized for peer review. The requirement for informed consent was waived due to the retrospective nature of the study and anonymization of patient data. Competing interests: The authors declare no competing interests. EDAT- 2026/02/27 13:05 MHDA- 2026/03/06 08:59 PMCR- 2026/02/27 CRDT- 2026/02/27 11:16 PHST- 2025/07/28 00:00 [received] PHST- 2026/02/17 00:00 [accepted] PHST- 2026/03/06 08:59 [medline] PHST- 2026/02/27 13:05 [pubmed] PHST- 2026/02/27 11:16 [entrez] PHST- 2026/02/27 00:00 [pmc-release] AID - 10.1186/s40510-026-00613-6 [pii] AID - 613 [pii] AID - 10.1186/s40510-026-00613-6 [doi] PST - epublish SO - Prog Orthod. 2026 Feb 27;27(1):8. doi: 10.1186/s40510-026-00613-6. PMID- 41758242 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20261009 IS - 1867-1632 (Electronic) IS - 0178-7888 (Linking) VI - 42 IP - 2 DP - 2026 Feb 27 TI - Occurrence and health risk assessment of AFM1 in commercial yogurt in Thailand. LID - 28 [pii] LID - 10.1007/s12550-026-00641-5 [doi] AB - Milk and dairy products, including yogurt, provide essential nutrients and are widely consumed as valuable protein sources. However, considering then increasing prevalence of Aflatoxin B1 (AFB1) in the diet of dairy cows, concerns arise regarding the possible contamination of milk and dairy products with AFM1, the major metabolite of AFB1 excreted in the milk of lactating animals. AFM1, although less potent when compared to AFB1, has been associated with an increase in the prevalence of human hepatic carcinoma. Hence, following a survey on AFM1 contamination of raw and processed drinking milk, this study aimed to evaluate the occurrence of aflatoxin M1 (AFM1) in yogurt available in Bangkok, Thailand, and to estimate the associated dietary exposure and health risk among different population groups. A total of 180 plain yogurt samples were randomly collected from supermarkets during March to June 2024. The samples were extracted using the QuEChERS methodology and analyzed using a validated liquid chromatography- tandem mass spectrometry method. With this method, residual amounts of AFM1 were detected in 12 out of 180 yoghurt samples, with concentrations ranging from 0.031 to 0.048 microg/kg. These levels are below the statutory limits set by the European Union and the FAO/WHO Joint Expert Committee. In addition, a quantitative risk assessment conducted for the AFM1 positive samples revealed that the margin of exposure (MOE) values derived for yogurt were above 10,000. The risk level of hepatocellular carcinoma due to AFM1 exposure expressed as the mean estimated number of liver cancer cases per 100,000 individuals per year ranged from 1.12 x 10(- 7) to 1.33 x 10(- 4) for the positive yogurt samples. Although the overall risk of AFM1 exposure is considered low for all age groups, children remain the most vulnerable population; therefore, continuous monitoring of dairy milk and milk products is warranted to minimize potential exposure. CI - (c) 2026. The Author(s) under exclusive licence to Society for Mycotoxin (Research Gesellschaft fur Mykotoxinforschung e.V.) and Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Ekaluckrujee, Usa AU - Ekaluckrujee U AD - Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand. FAU - Buated, Chamawan AU - Buated C AD - Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand. FAU - Vanigorn, Natthamon AU - Vanigorn N AD - Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand. FAU - Sriprathardtrakul, Thanaporn AU - Sriprathardtrakul T AD - Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand. FAU - Poapolathep, Saranya AU - Poapolathep S AD - Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand. FAU - Wattanasuntorn, Phattarawadee AU - Wattanasuntorn P AD - Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand. FAU - Fink-Gremmels, Johanna AU - Fink-Gremmels J AD - Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. FAU - Poapolathep, Amnart AU - Poapolathep A AD - Department of Pharmacology, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand. amnart.p@ku.th. LA - eng PT - Journal Article DEP - 20260227 PL - Germany TA - Mycotoxin Res JT - Mycotoxin research JID - 8807334 RN - 6795-23-9 (Aflatoxin M1) SB - IM MH - *Yogurt/analysis MH - *Aflatoxin M1/analysis MH - Thailand MH - Risk Assessment MH - *Food Contamination/analysis MH - Humans MH - Animals MH - Tandem Mass Spectrometry MH - Milk/chemistry MH - Cattle MH - Liquid Chromatography-Mass Spectrometry OTO - NOTNLM OT - Aflatoxin M1 OT - LC-MS/MS OT - Mycotoxin OT - Thailand OT - Yoghurt COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/02/27 13:07 MHDA- 2026/03/06 08:57 CRDT- 2026/02/27 11:05 PHST- 2025/09/30 00:00 [received] PHST- 2026/01/28 00:00 [accepted] PHST- 2026/01/23 00:00 [revised] PHST- 2026/03/06 08:57 [medline] PHST- 2026/02/27 13:07 [pubmed] PHST- 2026/02/27 11:05 [entrez] AID - 10.1007/s12550-026-00641-5 [pii] AID - 10.1007/s12550-026-00641-5 [doi] PST - epublish SO - Mycotoxin Res. 2026 Feb 27;42(2):28. doi: 10.1007/s12550-026-00641-5. PMID- 41757850 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260729 IS - 1525-1446 (Electronic) IS - 0737-1209 (Linking) VI - 43 IP - 3 DP - 2026 May-Jun TI - The Effect of Awareness-Based Disaster Education on Women's Disaster Awareness and Preparedness: A Randomized Controlled Study. PG - 757-767 LID - 10.1111/phn.70103 [doi] AB - OBJECTIVE: This study investigated the effect of awareness-based disaster education on women's disaster awareness and preparedness. MATERIALS AND METHODS: In a randomized controlled trial, 120 women who participated in public education center courses were randomly assigned to a control group and an experimental group (n = 60 each). Participants were women aged 18-65 in western Turkey. The participants in the experimental group received disaster education based on a structured awareness programme, while the control group received nutrition education. The validated instruments were used to assess disaster awareness and disaster preparedness. The intervention covered disaster types, preparedness strategies, emergency kits, evacuation plans, and basic first aid. Data were collected through face-to-face interviews using a form for sociodemographic characteristics, a form for disaster awareness assessment, and the Disaster Preparedness Scale. Pre-tests were administered to both groups, and post-tests were conducted four weeks after the intervention. RESULTS: After controlling for confounders and pre-test scores using ANCOVA, education was found to have a significant and large effect on the Disaster Preparedness Scale total score (p < 0.001; partial eta(2) = 0.70). The post-test scores of the experimental group were significantly higher than those of the control group. CONCLUSION: Women who received awareness-based disaster education improved disaster awareness and preparedness. It is recommended that this education be incorporated into disaster training programs. The community is more aware and prepared for natural disasters due to the measures that have been taken. TRIAL REGISTRATION: Iran Randomized Clinical Trial Center IRCT20240613062113N1 Registered on July 20, 2024. CI - (c) 2026 Wiley Periodicals LLC. FAU - Sogut, Seda Cangol AU - Sogut SC AUID- ORCID: 0000-0002-4655-0353 AD - Department of Midwifery, Faculty of Health Sciences, Canakkale Onsekiz Mart University, Canakkale, Turkey. FAU - Kilicarslan, Tugce AU - Kilicarslan T AUID- ORCID: 0009-0003-6043-8469 AD - Midwife. LA - eng GR - 1919B012304308/A TUBITAK Students Research Projects Support Program/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20260227 PL - United States TA - Public Health Nurs JT - Public health nursing (Boston, Mass.) JID - 8501498 SB - IM MH - Humans MH - Female MH - Turkey MH - Adult MH - *Disaster Planning/methods MH - *Health Knowledge, Attitudes, Practice MH - Middle Aged MH - *Health Education/methods MH - Adolescent MH - *Awareness MH - Young Adult MH - Aged OTO - NOTNLM OT - awareness OT - disaster awareness OT - disaster education OT - disaster preparedness OT - women EDAT- 2026/02/27 13:06 MHDA- 2026/04/24 18:35 CRDT- 2026/02/27 08:43 PHST- 2026/02/07 00:00 [revised] PHST- 2025/01/14 00:00 [received] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/04/24 18:35 [medline] PHST- 2026/02/27 13:06 [pubmed] PHST- 2026/02/27 08:43 [entrez] AID - 10.1111/phn.70103 [doi] PST - ppublish SO - Public Health Nurs. 2026 May-Jun;43(3):757-767. doi: 10.1111/phn.70103. Epub 2026 Feb 27. PMID- 41757156 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260227 LR - 20260813 IS - 2231-5047 (Print) IS - 2231-5128 (Electronic) IS - 2231-5047 (Linking) VI - 15 IP - 2 DP - 2025 Jul-Dec TI - Management of Drug-induced Dyspepsia in Children: Current Evidence and Clinical Approach. PG - 190-197 LID - 10.5005/jp-journals-10018-1495 [doi] AB - Drug-induced dyspepsia (DID) represents an often overlooked cause of upper gastrointestinal (GI) discomfort in children, frequently mimicking functional dyspepsia or gastroesophageal reflux disease (GERD). This review synthesizes current evidence on the diagnosis and management of pediatric DID, integrating expert consensus and available clinical data. Accurate diagnosis of pediatric DID depends on a thorough medication history, covering prescription, over-the-counter (OTC), and supplement use, alongside symptom correlation with drug exposure. Standardized tools such as the EMPACIP Likert dyspepsia severity scale may improve diagnostic precision and enable symptom monitoring. A stepwise management approach involves identifying and discontinuing or substituting the offending agent, implementing dietary and lifestyle modifications, and initiating pharmacologic therapy when needed. H(2)-receptor antagonists (H(2)RAs) are recommended as the preferred therapy due to their rapid onset, safety profile, and suitability for on-demand use, while proton pump inhibitors (PPIs) are suggested to be reserved for refractory or severe cases with mucosal injury. Prokinetic agents may have a role in select cases with motility-related symptoms, though evidence remains limited. Long-term or prophylactic use of acid-suppressive medications should be approached cautiously, with regular reassessment and tapering to prevent unnecessary exposure. Significant knowledge gaps persist regarding pediatric-specific diagnostic tools, epidemiology, and long-term outcomes. Future research should focus on validating symptom scales, clarifying drug-specific risk profiles, and developing integrated care models. An algorithmic, evidence-informed approach can help standardize care and improve outcomes for children affected by DID. HOW TO CITE THIS ARTICLE: Pai UA, Kesavelu D, Wadhwa A, et al. Management of Drug-induced Dyspepsia in Children: Current Evidence and Clinical Approach. Euroasian J Hepato-Gastroenterol 2025;15(2):190-197. CI - Copyright (c) 2025; The Author(s). FAU - Pai, Uday A AU - Pai UA AD - Department of Pediatrics, Sai Kutir, Mumbai, Maharashtra, India. FAU - Kesavelu, Dhanasekhar AU - Kesavelu D AUID- ORCID: 0000-0003-4051-3102 AD - Department of Pediatric Gastroenterology, Apollo Hospitals, Chennai, Tamil Nadu, India. FAU - Wadhwa, Arun AU - Wadhwa A AD - Departments of Pediatrics, Rainbow Children's Hospital, New Delhi, India. FAU - Pillai, Bhanu V AU - Pillai BV AD - Department of Pediatrics, Amrita Institute of Medical Sciences, Kochi, Kerala, India. FAU - Ravishankar, Ayathu V AU - Ravishankar AV AD - Department of Pediatrics, Kauvery Hospital, Alwarpet, and MK Hospital, Chennai, Tamil Nadu, India. FAU - Bharadia, Lalit AU - Bharadia L AUID- ORCID: 0000-0003-1872-0367 AD - Department of Pediatric Gastroenterology, Neoclinic Children Hospital, Jaipur, Rajasthan, India. FAU - Bhattacharyya, Subhashish AU - Bhattacharyya S AD - Department of Pediatrics, CSS College, Kolkata, West Bengal, India. FAU - Jog, Pramod AU - Jog P AD - Department of Pediatrics, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Pune, Maharashtra, India. LA - eng PT - Journal Article PT - Review DEP - 20260116 PL - India TA - Euroasian J Hepatogastroenterol JT - Euroasian journal of hepato-gastroenterology JID - 101577625 PMC - PMC12932292 OTO - NOTNLM OT - Acid-suppressive therapy OT - Drug-induced dyspepsia OT - Dyspepsia severity scale OT - H2-receptor antagonists OT - Lansoprazole OT - Pediatric gastroenterology OT - Proton pump inhibitors OT - Ranitidine COIS- Source of support: Nil Conflict of interest: NoneConflict of interest: None EDAT- 2026/02/27 06:32 MHDA- 2026/02/27 06:33 PMCR- 2025/07/01 CRDT- 2026/02/27 05:05 PHST- 2025/11/12 00:00 [received] PHST- 2025/12/16 00:00 [accepted] PHST- 2026/02/27 06:33 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 05:05 [entrez] PHST- 2025/07/01 00:00 [pmc-release] AID - 10.5005/jp-journals-10018-1495 [doi] PST - ppublish SO - Euroasian J Hepatogastroenterol. 2025 Jul-Dec;15(2):190-197. doi: 10.5005/jp-journals-10018-1495. Epub 2026 Jan 16. PMID- 41756570 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260227 LR - 20260813 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - A study protocol for a therapist guided digital cognitive-behavioral therapy for children with avoidant/restrictive food intake disorder and their parents. PG - 1743480 LID - 10.3389/fpsyt.2026.1743480 [doi] LID - 1743480 AB - BACKGROUND: Avoidant/restrictive food intake disorder (ARFID) is an eating disorder prevalent in children and associated with several health and psychosocial impairments. Despite its prevalence, limited treatment services are available and children with ARFID often do not receive specialized care. Cognitive-behavioral therapy has shown feasibility in face-to-face trials supporting proof-of-concept. Digital interventions could increase treatment accessibility in this population. METHODS: In a single-armed intervention trial (N = 40) children aged 8-14 years with a primary diagnosis of ARFID and their caregivers will receive a digital cognitive-behavioral therapy. The intervention consists of a 12-session program, combining video therapy sessions with children and caregivers and self-guided modules. Assessments occur at baseline, mid-treatment, post-treatment, and 4-week follow-up with additional symptom monitoring questionnaires per session. Primary outcomes include feasibility, recruitment and retention rate. Secondary outcomes include ARFID symptoms (e.g., Eating Disorder Examination ARFID module, Nine Item Avoidant/Restrictive Food Intake Disorder screen), food neophobia (Food Neophobia Scale) and quality of life (Generic Quality of Life Instrument for Children-Revised). DISCUSSION: This study evaluates the feasibility and proof of concept of a therapist-guided digital intervention for ARFID. If feasible and acceptable, the digital intervention may help to increase treatment access for children with ARFID in German-speaking countries. Furthermore, findings can inform future larger-scale randomized control trials and the development of digital interventions for ARFID. CLINICAL TRIAL REGISTRATION: https://drks.de/search/de/trial/DRKS00038026/details, identifier DRKS00038026. CI - Copyright (c) 2026 Engelkamp, Koeder, Dalholf, Thomas, Eddy and Hartmann. FAU - Engelkamp, Julia E AU - Engelkamp JE AD - Department of Psychology, Clinical Psychology and Psychotherapy of Childhood and Adolescence, Konstanz University, Konstanz, Germany. FAU - Koeder, Lara-Marie AU - Koeder LM AD - Department of Psychology, Clinical Psychology and Psychotherapy of Childhood and Adolescence, Konstanz University, Konstanz, Germany. FAU - Dalholf, Manuela AU - Dalholf M AD - Department of Psychology, Clinical Psychology and Psychotherapy of Childhood and Adolescence, Konstanz University, Konstanz, Germany. FAU - Thomas, Jennifer J AU - Thomas JJ AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, United States. AD - Department of Psychiatry, Harvard Medical School, Boston, MA, United States. FAU - Eddy, Kamryn T AU - Eddy KT AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Boston, MA, United States. AD - Department of Psychiatry, Harvard Medical School, Boston, MA, United States. AD - Division of Child and Adolescent Psychiatry, AMC Department of Psychiatry, Massachusetts General Brigham, Boston, MA, United States. FAU - Hartmann, Andrea S AU - Hartmann AS AD - Department of Psychology, Clinical Psychology and Psychotherapy of Childhood and Adolescence, Konstanz University, Konstanz, Germany. LA - eng PT - Journal Article DEP - 20260211 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC12933427 OTO - NOTNLM OT - CBT-AR OT - avoidant restrictive food intake disorder OT - children OT - digital intervention OT - sensory sensitivity OT - treatment outcomes OT - virtual treatment COIS- Authors JT and KE receive royalties from Cambridge University Press for the sale of their books on cognitive-behavioral therapy for avoidant/restrictive food intake disorder. They have also received consulting fees from Equip Health. The remaining author(s) declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author AH declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/02/27 06:31 MHDA- 2026/02/27 06:32 PMCR- 2026/02/11 CRDT- 2026/02/27 05:01 PHST- 2025/11/10 00:00 [received] PHST- 2026/01/09 00:00 [revised] PHST- 2026/01/14 00:00 [accepted] PHST- 2026/02/27 06:32 [medline] PHST- 2026/02/27 06:31 [pubmed] PHST- 2026/02/27 05:01 [entrez] PHST- 2026/02/11 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1743480 [doi] PST - epublish SO - Front Psychiatry. 2026 Feb 11;17:1743480. doi: 10.3389/fpsyt.2026.1743480. eCollection 2026. PMID- 41756095 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Construction and application of coordination ability evaluation tool for children aged 4-5.9 years old. PG - 1698428 LID - 10.3389/fpubh.2026.1698428 [doi] LID - 1698428 AB - BACKGROUND: Coordination ability is a critical component influencing children's basic motor skills and participation in physical activities. Positive experiences formed during early movement practice are essential for lifelong health. PURPOSE: This study aimed to scientifically construct a systematic and user-friendly evaluation tool for assessing coordination ability in children aged 4.0-5.9 years, thereby enhancing understanding and promoting targeted development in family and kindergarten activities. METHODS: The evaluation indicators were determined through literature review, structured expert interviews, expert interviews, and the Delphi method. Sixteen cities in Shandong Province were sampled using a stratified random cluster sampling approach. A total of 1,068 valid samples were obtained (530 children aged 4.0-4.9 years and 538 children aged 5.0-5.9 years). Statistical analyses were performed using SPSS 26.0 and AMOS 26.0, including exploratory and confirmatory factor analyses to test model validity. RESULTS: The structural model of coordination ability demonstrated good fit indices. Coordination ability was found to consist of six key dimensions: balance, spatial orientation, rhythm, perceptual judgment, limb coordination, and limb movement range. Evaluation criteria for both 4- and 5-year-old groups were established. Girls exhibited higher overall coordination scores than boys. Boys in the 4-year-old group showed superior perceptual and judgment ability, while boys in the 5-year-old group performed better in perceptual judgment and spatial orientation. CONCLUSION: (1) The constructed evaluation tool accurately reflects children's coordination development. (2) The established single and composite scoring criteria effectively distinguish coordination levels among children aged 4-5.9 years. (3) Gender differences exist, with girls generally outperforming boys, though developmental asynchrony is evident across coordination components. CI - Copyright (c) 2026 Chen and Li. FAU - Chen, Weifu AU - Chen W AD - Department of Physical Education, Beijing Union University, Beijing, China. FAU - Li, Na AU - Li N AD - School of Physical Education, Shandong University of Science and Technology, Qingdao, China. LA - eng PT - Journal Article DEP - 20260211 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Child, Preschool MH - Male MH - *Motor Skills/physiology MH - Female MH - China MH - *Child Development/physiology MH - Delphi Technique PMC - PMC12932535 OTO - NOTNLM OT - assessment criteria OT - basic motor skill OT - coordination ability OT - evaluation index system OT - preschool children COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/27 06:32 MHDA- 2026/03/06 13:45 PMCR- 2026/02/11 CRDT- 2026/02/27 04:56 PHST- 2025/09/03 00:00 [received] PHST- 2025/12/15 00:00 [revised] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/03/06 13:45 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 04:56 [entrez] PHST- 2026/02/11 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1698428 [doi] PST - epublish SO - Front Public Health. 2026 Feb 11;14:1698428. doi: 10.3389/fpubh.2026.1698428. eCollection 2026. PMID- 41756071 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Current situation and influencing factors of scientific literacy in fitness of Chinese children and adolescents. PG - 1760827 LID - 10.3389/fpubh.2026.1760827 [doi] LID - 1760827 AB - OBJECTIVE: This study aimed to develop and validate a scientific fitness literacy (SFL) assessment model for Chinese children and adolescents and to examine the associations between SFL and its key influencing factors within an integrated social-ecological and self-determination theory framework. METHODS: Data were collected from 147,104 students (grades 4-12) across 31 provinces in mainland China using a multi-stage cluster random sampling design. SFL was assessed across four dimensions: knowledge, attitude, skills, and habits. The relative contributions of five influencing factors-lifestyle, individual socialization, family, school, and social environment-were analyzed using multiple regression models. RESULTS: The overall SFL index was 65.8 (range 0-100), with knowledge (59.2) and skills (58.2) scoring below the passing threshold. Lifestyle (beta = 0.264) and individual socialization (beta = 0.240) were the strongest predictors of SFL, followed by family environment (beta = 0.211), social environment (beta = 0.153), and school environment (beta = 0.101). The school environment exhibited the lowest marginal utility. CONCLUSION: The integrated framework provides a more comprehensive explanatory model for SFL than approaches that focus solely on internal factors. Interventions should prioritize lifestyle and socialization while placing greater emphasis on family and social environments rather than relying solely on school-based factors. CI - Copyright (c) 2026 Zhang, Zhao, Chen, Chen, Wang, Li, Naito and Deng. FAU - Zhang, Yanfeng AU - Zhang Y AD - National Physical Fitness Research Center, China Institute of Sport Science, Beijing, China. AD - Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. FAU - Zhao, Deqiang AU - Zhao D AD - National Physical Fitness Research Center, China Institute of Sport Science, Beijing, China. FAU - Chen, Xiaoxiao AU - Chen X AD - School of Physical Education and Sports Rehabilitation, Jinzhou Medical University, Jinzhou, Liaoning, China. FAU - Chen, Jiaxing AU - Chen J AD - National Physical Fitness Research Center, China Institute of Sport Science, Beijing, China. FAU - Wang, Chunmiao AU - Wang C AD - National Physical Fitness Research Center, China Institute of Sport Science, Beijing, China. FAU - Li, Sen AU - Li S AD - Jiangsu Institute of Sports Science, Nanjing, China. FAU - Naito, Hisashi AU - Naito H AD - Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. FAU - Deng, Pengyu AU - Deng P AD - Graduate School of Health and Sports Science, Juntendo University, Chiba, Japan. LA - eng PT - Journal Article DEP - 20260211 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Chinese people SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - China MH - *Health Knowledge, Attitudes, Practice MH - Life Style MH - *Physical Fitness MH - Social Environment MH - Socialization MH - Surveys and Questionnaires MH - East Asian People PMC - PMC12932448 OTO - NOTNLM OT - children and adolescents OT - influencing factors OT - scientific fitness literacy OT - self-determination theory OT - social-ecological theory COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/27 06:32 MHDA- 2026/03/08 01:38 PMCR- 2026/02/11 CRDT- 2026/02/27 04:56 PHST- 2025/12/19 00:00 [received] PHST- 2026/01/09 00:00 [revised] PHST- 2026/01/23 00:00 [accepted] PHST- 2026/03/08 01:38 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 04:56 [entrez] PHST- 2026/02/11 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1760827 [doi] PST - epublish SO - Front Public Health. 2026 Feb 11;14:1760827. doi: 10.3389/fpubh.2026.1760827. eCollection 2026. PMID- 41755505 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260813 IS - 1467-789X (Electronic) IS - 1467-7881 (Print) IS - 1467-7881 (Linking) VI - 27 IP - 8 DP - 2026 Aug TI - Comparative Effects of 12 Exercise Modalities on Body Mass Index and Body Fat Percentage in Youth With Overweight or Obesity: A Systematic Review and Network Meta-Analysis. PG - e70113 LID - 10.1111/obr.70113 [doi] LID - e70113 AB - OBJECTIVE: This study aimed to compare 12 exercise interventions on body mass index (BMI) and body fat percentage (BF%) in youth with overweight or obesity using a network meta-analysis to inform intervention and weight management strategies. METHODS: We conducted a search of Scopus, Embase, Cochrane Library, PubMed, and Web of Science databases for randomized controlled trials examining exercise interventions on body composition in children and adolescents with overweight or obesity, covering all studies available up to October 24, 2025. Two researchers independently screened the literature, extracted data, and assessed the risk of bias in the included studies. Statistical analysis was performed using R. RESULTS: Sixty-three randomized controlled trials involving 2724 children and adolescents with overweight or obesity were included in the analysis. Pairwise meta-analysis revealed that 40% of exercise types showed no significant impact on BMI, and 30% showed no significant impact on BF%. The results from the network meta-analysis were largely consistent with those from pairwise meta-analysis when compared to control groups. The top five interventions for reducing BMI were moderate-intensity continuous training (MICT), high-intensity interval training (HIIT), combined aerobic-resistance training (CT), moderate-to-vigorous aerobic exercise (MVAE), and multicomponent exercise (MCE). For BF%, the top five interventions were CT, resistance training (RT), MICT, HIIT, and MVAE. CONCLUSION: MICT, CT, and HIIT performed favorably, with outcome-specific advantages. MICT ranked highest for BMI, CT was highest for BF% (SUCRA), and HIIT offered time-efficient benefits across outcomes versus control; results support tailoring modality choice to goals and feasibility to improve adherence. CI - (c) 2026 World Obesity Federation. FAU - Wu, Jiarong AU - Wu J AD - School of Physical Education, Soochow University, Suzhou, China. FAU - Fang, Mingqing AU - Fang M AD - Xiangya School of Medicine, Central South University, Changsha, China. FAU - Xiao, Ningkun AU - Xiao N AUID- ORCID: 0000-0002-0615-3222 AD - Department of Psychology, Ural Federal University, Yekaterinburg, Russia. FAU - Zhang, Qiuxia AU - Zhang Q AD - School of Physical Education, Soochow University, Suzhou, China. FAU - Zang, Wanli AU - Zang W AUID- ORCID: 0000-0002-9712-4557 AD - School of Physical Education, Soochow University, Suzhou, China. LA - eng PT - Comparative Study PT - Journal Article PT - Network Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20260226 PL - England TA - Obes Rev JT - Obesity reviews : an official journal of the International Association for the Study of Obesity JID - 100897395 SB - IM MH - Humans MH - *Body Mass Index MH - Adolescent MH - *Exercise/physiology MH - Child MH - *Pediatric Obesity/therapy MH - Body Composition/physiology MH - *Exercise Therapy/methods MH - Randomized Controlled Trials as Topic MH - *Adipose Tissue MH - *Overweight/therapy PMC - PMC13371392 OTO - NOTNLM OT - adolescents OT - children OT - network meta-analysis OT - obesity OT - overweight OT - physical activity COIS- The authors declare no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/02/27 06:31 MHDA- 2026/07/15 12:35 PMCR- 2026/07/15 CRDT- 2026/02/27 02:13 PHST- 2025/12/31 00:00 [revised] PHST- 2025/06/13 00:00 [received] PHST- 2026/02/03 00:00 [accepted] PHST- 2026/07/15 12:35 [medline] PHST- 2026/02/27 06:31 [pubmed] PHST- 2026/02/27 02:13 [entrez] PHST- 2026/07/15 00:00 [pmc-release] AID - OBR70113 [pii] AID - 10.1111/obr.70113 [doi] PST - ppublish SO - Obes Rev. 2026 Aug;27(8):e70113. doi: 10.1111/obr.70113. Epub 2026 Feb 26. PMID- 41755496 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260316 LR - 20260813 IS - 2979-9139 (Electronic) IS - 2979-9139 (Linking) VI - 27 IP - 2 DP - 2026 Mar 12 TI - The Relationship Between Peripheral Eosinophilia, Lower Respiratory Tract Pathogens, Age at First Pneumonia, and Malnutrition in Children with Non-cystic Fibrosis Bronchiectasis. PG - 96-102 LID - 10.4274/ThoracResPract.2026.2025-9-3 [doi] AB - OBJECTIVE: Non-cystic fibrosis (non-CF) bronchiectasis is a chronic lung disease, primarily characterised by neutrophilic inflammation, with Haemophilus influenzae (HI) frequently isolated from respiratory cultures. Recent adult studies have suggested a potential role for eosinophils in the frequency of pulmonary exacerbations and in lung function decline. This study aimed to evaluate the relationships among peripheral eosinophilia, lower respiratory tract pathogens, age at first pneumonia, and malnutrition in children with non-CF bronchiectasis. MATERIAL AND METHODS: In this retrospective study, children who were diagnosed with non-CF bronchiectasis were grouped based on nutritional status, eosinophilia, age at first pneumonia, and the most frequently isolated microorganisms. Clinical outcomes were compared across groups. RESULTS: Among 106 patients (61.3% male), malnutrition was present in 48.1% and eosinophilia in 39.6%. Primary immunodeficiency was the most common etiology (39.6%). HI and Pseudomonas aeruginosa (PA) were isolated in 61.3% and 24.5% of respiratory cultures, respectively. Patients with malnutrition had significantly lower forced expiratory volume in one second and forced vital capacity (FVC) values (P = 0.023 and P = 0.005, respectively). Eosinophilia was more prevalent in patients with PA isolation; was associated with younger ages at first pneumonia and bronchiectasis diagnoses (P = 0.009 and P = 0.017). PA isolation was associated with a higher frequency of aspiration syndromes (P < 0.001) and lower FVC values (P = 0.040). Patients who experienced their first episode of pneumonia before the age of two had more frequent exacerbations and were diagnosed with bronchiectasis at an earlier age. CONCLUSION: Non-CF bronchiectasis in childhood may be preventable and/or non-progressive when diagnosed early. Clinical features such as malnutrition, eosinophilia, PA isolation, and early-onset pneumonia may help identify children who could benefit from closer clinical monitoring. Further pediatric studies are needed to validate these associations. CI - Copyright(c) 2026 The Author(s). Published by Galenos Publishing House on behalf of Turkish Thoracic Society. FAU - Olgun, Esin Gizem AU - Olgun EG AUID- ORCID: 0000-0002-1279-8510 AD - Department of Pediatric Pulmonology, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Ozcan, Gizem AU - Ozcan G AUID- ORCID: 0000-0001-9063-4063 AD - Department of Pediatric Pulmonology, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Zirek, Fazilcan AU - Zirek F AUID- ORCID: 0000-0002-2146-9284 AD - Department of Pediatric Pulmonology, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Tekin, Merve Nur AU - Tekin MN AUID- ORCID: 0000-0003-4541-5704 AD - Department of Pediatric Pulmonology, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Bayav, Secahattin AU - Bayav S AUID- ORCID: 0000-0001-8342-1078 AD - Department of Pediatric Pulmonology, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Turgut, Mahmut AU - Turgut M AUID- ORCID: 0000-0001-9644-0120 AD - Department of Pediatric Pulmonology, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Agirtici, Mukaddes AU - Agirtici M AUID- ORCID: 0000-0002-6469-3104 AD - Department of Pediatric Pulmonology, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Kucuk Ozturk, Semra AU - Kucuk Ozturk S AUID- ORCID: 0009-0005-0384-7658 AD - Department of Pediatric Pulmonology, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Celik Mertese, Seyhan AU - Celik Mertese S AUID- ORCID: 0000-0002-4704-1729 AD - Department of Pediatric Pulmonology, Ankara University Faculty of Medicine, Ankara, Turkiye. FAU - Cobanoglu, Nazan AU - Cobanoglu N AUID- ORCID: 0000-0002-3686-2927 AD - Department of Pediatric Pulmonology, Ankara University Faculty of Medicine, Ankara, Turkiye. LA - eng PT - Journal Article DEP - 20260227 PL - Turkey TA - Thorac Res Pract JT - Thoracic research and practice JID - 9918609982606676 PMC - PMC13002249 OTO - NOTNLM OT - Bronchiectasis OT - Pseudomonas aeruginosa OT - eosinophilia OT - malnutrition COIS- No conflict of interest was declared by the authors. EDAT- 2026/02/27 06:31 MHDA- 2026/02/27 06:32 PMCR- 2026/03/12 CRDT- 2026/02/27 02:12 PHST- 2026/02/27 06:32 [medline] PHST- 2026/02/27 06:31 [pubmed] PHST- 2026/02/27 02:12 [entrez] PHST- 2026/03/12 00:00 [pmc-release] AID - 10.4274/ThoracResPract.2026.2025-9-3 [doi] PST - ppublish SO - Thorac Res Pract. 2026 Mar 12;27(2):96-102. doi: 10.4274/ThoracResPract.2026.2025-9-3. Epub 2026 Feb 27. PMID- 41755411 OWN - NLM STAT- Publisher LR - 20260227 IS - 1996-3181 (Electronic) IS - 1871-5273 (Linking) DP - 2026 Feb 23 TI - Neuroprotective Marine Bioactives in Paediatric ADHD: A Focused Review on Therapeutic Potential. LID - 10.2174/0118715273418458251114104948 [doi] AB - INTRODUCTION: Attention-Deficit/Hyperactivity Disorder (ADHD) is a common neurodevelopmental condition in children, marked by symptoms of inattention, hyperactivity, and impulsivity. This review examines the potential of marine-derived bioactive compounds as promising alternatives to support neurodevelopment and aid in managing ADHD-related symptoms. METHODS: Databases such as PubMed, Scopus, Web of Science, and ClinicalTrials.gov were searched using terms related to marine bioactives and ADHD. Studies published up to July 2025 were considered, focusing on human clinical trials and preclinical research involving children or outcomes related to neurodevelopment. Reviews focusing on marine-based sources have increasingly highlighted their potential in enhancing cognitive function, attention regulation, and overall neurodevelopment in children with ADHD. This review offers a targeted analysis of marine-derived compounds with potential therapeutic value in the management of ADHD in children. RESULTS: Marine sources offer several neuroprotective agents, including Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA), which are critical for brain development, especially in children. Compounds such as Klamin(R), derived from Aphanizomenon flos-aquae, contain betaphenylethylamine and phycocyanins that exhibit monoamine oxidase B inhibition and may support attention regulation. Bioactive peptides and marine polysaccharides also demonstrate significant anti- inflammatory and neuroregenerative potential. DISCUSSION: Marine bioactives represent a unique and largely untapped avenue for ADHD management through nutritional and functional interventions. Compared to conventional pharmacological treatments, these compounds offer natural, potentially safer options. However, clinical studies are limited, and further research is needed to establish efficacy, optimal dosing, and long-term safety. CONCLUSION: Marine-derived compounds exhibit promising neuroprotective and cognitiveenhancing properties relevant to the management of ADHD. Future research and clinical validation may pave the way for integrating these natural agents into therapeutic and dietary strategies for children with ADHD. CI - Copyright(c) Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. FAU - Chaudhary, Benu AU - Chaudhary B AD - Department of Pharmacy, Panipat Institute of Engineering and Technology, Panipat, Haryana, India. FAU - Arya, Preeti AU - Arya P AD - Shri Ram College of Pharmacy, Ramba, Karnal, Haryana, India. FAU - Kumar, Praveen AU - Kumar P AD - NIMS Institute of Pharmacy, National Institute of Medical Sciences, Jaipur, Rajasthan, India. FAU - Agarwal, Gaurav AU - Agarwal G AD - Department of Pharmacy, Panipat Institute of Engineering and Technology, Panipat, Haryana, India. FAU - Grewal, Ajmer Singh AU - Grewal AS AD - Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India. LA - eng PT - Journal Article DEP - 20260223 PL - United Arab Emirates TA - CNS Neurol Disord Drug Targets JT - CNS & neurological disorders drug targets JID - 101269155 SB - IM OTO - NOTNLM OT - Neuroprotection OT - anti-inflammatory OT - antioxidant OT - attention-deficit disorder OT - hyperactivity disorder OT - marine bioactives OT - neuroregenerative properties. EDAT- 2026/02/27 06:31 MHDA- 2026/02/27 06:31 CRDT- 2026/02/27 01:33 PHST- 2025/06/22 00:00 [received] PHST- 2025/08/09 00:00 [revised] PHST- 2025/08/15 00:00 [accepted] PHST- 2026/02/27 06:31 [medline] PHST- 2026/02/27 06:31 [pubmed] PHST- 2026/02/27 01:33 [entrez] AID - CNSNDDT-EPUB-153117 [pii] AID - 10.2174/0118715273418458251114104948 [doi] PST - aheadofprint SO - CNS Neurol Disord Drug Targets. 2026 Feb 23. doi: 10.2174/0118715273418458251114104948. PMID- 41755349 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260926 IS - 1879-3479 (Electronic) IS - 0020-7292 (Print) IS - 0020-7292 (Linking) VI - 173 IP - 3 DP - 2026 Jun TI - Artificial intelligence for personalized multiple micronutrient supplementation in maternal health. PG - 1163-1173 LID - 10.1002/ijgo.70911 [doi] AB - Maternal undernutrition and micronutrient deficiencies remain pervasive, contributing to adverse pregnancy outcomes and long-term health risks for mothers and offspring. Multiple micronutrient supplementation (MMS) during pregnancy has demonstrated benefits, including reduced risks of low birth weight, small-for-gestational-age births, and neonatal mortality, when compared with standard iron-folic acid supplementation. Current MMS strategies, however, often follow a standard MMS, overlooking variations in nutritional status, health profiles, and context. Advances in artificial intelligence (AI), particularly deep learning and natural language processing, provide opportunities to strengthen maternal nutrition programs by integrating diverse data sources. Rather than promising fully individualized recommendations, AI could help stratify women by risk of insufficiencies or deficiencies, highlight groups most likely to benefit from additional support, and inform the design of more responsive supplementation strategies during preconception and pregnancy. We outline a conceptual model in which multimodal health data-including electronic health records (EHRs), wearable sensor outputs, nutrition and fertility app logs, genomic markers, and sociodemographic information-are aggregated and analyzed by AI systems to inform personalized MMS plans. The framework introduces the concept of a "nutritional digital twin," a virtual profile of the patient's nutritional and metabolic state. This digital twin can simulate micronutrient needs and predict maternal-fetal outcomes under different supplementation scenarios, enabling clinicians to test scenario-based options (e.g. standard MMS +/- targeted add-ons) for individuals. We describe how deep learning models can identify complex patterns (e.g. diet-genome interactions or behavioral trends) while natural language processing (NLP) algorithms extract clinically relevant insights from unstructured data (such as medical notes or patient queries). In addition, we discuss the role of digital maternal health tools, such as mobile apps and wearable trackers, in supplying real-time data to the AI models and in engaging women to improve adherence to supplementation regimens. Harnessing AI for MMS could transform maternal nutrition care in both high- and low-resource settings. In high-income contexts, rich data (comprehensive EHRs, genetic tests, continuous monitoring devices) could feed advanced predictive models to support risk-stratified care with protocolized supplementation options, under clinical oversight. In low- and middle-income countries, where maternal undernutrition and micronutrient gaps are most prevalent, AI-driven approaches can help stratify risk groups and optimize limited resources. Ubiquitous mobile phone access and digital health tools in many such settings provide avenues for data collection and intervention delivery. We highlight examples where machine learning on population data revealed "hidden hunger" patterns and key predictors of low supplement uptake (e.g. low education, minimal antenatal visits)-insights that policymakers can use to target nutrition programs. A nutritional digital twin could further allow scenario-testing (e.g. predicting the impact of adding a vitamin D supplement for a specific patient) before clinical decisions are made. To realize this vision, the key concerns are ethics, credibility, and fairness. Ethical frameworks must guide development so that sensitive reproductive health data are protected and clinician oversight remains central. The credibility of AI-generated recommendations depends on transparency about the assumptions used to translate nutritional and health data into supplement type and dose, and on prospective validation against maternal and neonatal outcomes. This requires a continuous feedback loop in which recommendations are tested in real-world settings and recalibrated using outcomes data, ensuring that the system learns from observed benefits and harms, rather than relying solely on theoretical modeling. Fairness demands that training data sets represent diverse populations and that solutions are tailored to local contexts to reduce bias and avoid widening disparities. Critically, the approach must be fed by data streams that extend beyond initial demographics and clinical baselines to include biomarkers, adherence patterns, and pregnancy outcomes, so that the models can be refined and dosing rules adjusted over time. If these safeguards are embedded, AI-enhanced personalized MMS can move beyond proof of concept towards a credible, equitable, and empirically grounded contribution to global maternal health. AI-driven personalized nutrition support represents a frontier in obstetric care. By combining clinical knowledge with data-driven intelligence, we can move beyond generalized prenatal supplements towards precision maternal nutrition. The integration of deep learning models and digital health innovations into antenatal care pathways has the potential to better nourish pregnancies, save lives, and ensure healthier futures for mothers and children worldwide. CI - (c) 2026 The Author(s). International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics. FAU - Davis Jones, Gabriel AU - Davis Jones G AUID- ORCID: 0000-0003-4070-4814 AD - Oxford Digital Health Labs, Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK. FAU - Papageorghiou, Aris T AU - Papageorghiou AT AD - Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, UK. AD - Oxford Maternal and Perinatal Health Institute (OMPHI), University of Oxford, Oxford, UK. FAU - Shehata, Hassan AU - Shehata H AD - Royal College of Obstetricians and Gynaecologists, London, UK. FAU - Divakar, Hema AU - Divakar H AD - Divakars Speciality Hospital, Bengaluru, India. FAU - Van der Beek, Eline M AU - Van der Beek EM AD - Department of Pediatrics, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands. AD - Nestle Institute of Health Sciences, Nestle Research, Lausanne, Switzerland. FAU - Senikas, Vyta AU - Senikas V AD - Faculty of Medicine, McGill University, Montreal, Quebec, Canada. FAU - Konje, Justin C AU - Konje JC AD - Feto Maternal Centre, Doha, Qatar. AD - Department of Obstetrics and Gynecology, Weill Cornell Medicine, Doha, Qatar. AD - Department of Health Sciences, University of Leicester, Leicester, UK. FAU - Kihara, Anne-Beatrice AU - Kihara AB AD - Department of Obstetrics & Gynaecology, University of Nairobi, Nairobi, Kenya. FAU - Hod, Moshe AU - Hod M AD - Sackler Faculty of Medicine, Tel Aviv University, Tel-Aviv, Israel. CN - FIGO Committee on Women's Health and Technology LA - eng PT - Journal Article PT - Review DEP - 20260226 PL - United States TA - Int J Gynaecol Obstet JT - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JID - 0210174 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Female MH - *Micronutrients/administration & dosage/deficiency MH - Pregnancy MH - *Dietary Supplements MH - *Maternal Health MH - *Artificial Intelligence MH - Pregnancy Complications/prevention & control MH - *Precision Medicine/methods MH - Maternal Nutritional Physiological Phenomena MH - Pregnancy Outcome MH - Nutritional Status MH - Digital Health PMC - PMC13173597 OTO - NOTNLM OT - artificial intelligence OT - digital maternal health OT - low- and middle-income countries OT - maternal nutrition OT - multiple micronutrient supplementation OT - nutritional digital twin OT - personalized nutrition OT - risk stratification COIS- The authors have no conflicts of interest. EDAT- 2026/02/27 06:32 MHDA- 2026/05/14 14:49 PMCR- 2026/05/14 CRDT- 2026/02/27 01:22 PHST- 2026/01/20 00:00 [revised] PHST- 2025/11/19 00:00 [received] PHST- 2026/02/06 00:00 [accepted] PHST- 2026/05/14 14:49 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 01:22 [entrez] PHST- 2026/05/14 00:00 [pmc-release] AID - IJGO70911 [pii] AID - 10.1002/ijgo.70911 [doi] PST - ppublish SO - Int J Gynaecol Obstet. 2026 Jun;173(3):1163-1173. doi: 10.1002/ijgo.70911. Epub 2026 Feb 26. PMID- 41754226 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260926 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 4 DP - 2026 Feb 23 TI - Quality of Anthropometric Data for Child Nutrition Monitoring in India: A Comparative Assessment Using Two Rounds of the National Family Health Survey. LID - 10.3390/nu18040709 [doi] LID - 709 AB - BACKGROUND: High-quality anthropometric data are critical for accurately monitoring child nutritional outcomes and informing policy decisions, yet inconsistencies in measurement and reporting across large-scale surveys continue to challenge data reliability. METHOD: This research assesses the quality of height-for-age (HAZ), weight-for-age (WAZ), and weight-for-height (WHZ) z-scores based on a repeated cross-sectional analysis of two rounds of the National Family Health Survey (NFHS-4, 2015-2016 and NFHS-5, 2019-2021), examining improvements, persistent gaps, and regional disparities. We have used WHO-recommended diagnostics including digit preference, age-heaping, completeness of measurements, biologically implausible values, and distributional properties of z-scores to evaluate the plausibility of anthropometric data and generate state-level rankings to compare transitions across rounds. RESULTS: The results indicate modest national-level improvements in data quality in NFHS-5, particularly reductions in digit preference and implausible values; however, substantial inter-state variation remains, with some states demonstrating clear progress while others continue to exhibit measurement anomalies. The completeness of date of birth improved from 99.0% in NFHS-4 to 99.9% in NFHS-5, while completeness of anthropometric measurements declined from 98.5% to 96.6%. Digit preference for height decreased from 15.2% to 14.4%, and the proportion of biologically implausible HAZ values declined from 3.4% to 2.3%. However, the standard deviation of HAZ increased from 1.77 to 1.85 and that of WHZ from 1.40 to 1.50, indicating persistent measurement variability. Transitions in HAZ rankings further reveal mixed patterns of advancement and stagnation, with regional clustering of improvements more evident in certain parts of the country. Overall, while NFHS-5 reflects progress in anthropometric data quality, key challenges persist related to inconsistent adherence to measurement protocols, variable field performance, and inadequate supervisory oversight. CONCLUSIONS: Strengthening training, standardizing procedures, and reinforcing monitoring mechanisms are essential for achieving more reliable anthropometric data, thereby enhancing the accuracy of child nutrition estimates and supporting more evidence-based policy interventions in India. FAU - Dwivedi, Laxmi Kant AU - Dwivedi LK AUID- ORCID: 0000-0001-9737-2844 AD - Department of Survey Research & Data Analytics, International Institute for Population Sciences, Govandi Station Road, Deonar, Mumbai 400088, India. FAU - Jana, Somnath AU - Jana S AUID- ORCID: 0009-0000-5870-5247 AD - Department of Survey Research & Data Analytics, International Institute for Population Sciences, Govandi Station Road, Deonar, Mumbai 400088, India. FAU - Chauhan, Rupalee Singh AU - Chauhan RS AUID- ORCID: 0009-0009-1627-5985 AD - Department of Survey Research & Data Analytics, International Institute for Population Sciences, Govandi Station Road, Deonar, Mumbai 400088, India. FAU - Bhatia, Mrigesh AU - Bhatia M AUID- ORCID: 0000-0001-9366-142X AD - Department of Health Policy, London School of Economics, London WC2A 2AE, UK. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260223 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - India MH - *Anthropometry/methods MH - Cross-Sectional Studies MH - *Nutrition Surveys MH - Child, Preschool MH - Female MH - *Nutritional Status MH - Male MH - *Child Nutritional Physiological Phenomena MH - *Data Accuracy MH - Child MH - Infant MH - Reproducibility of Results MH - Body Height MH - Body Weight MH - Health Surveys PMC - PMC12943685 OTO - NOTNLM OT - DHS OT - India OT - NFHS OT - anthropometric data quality OT - digit preference OT - stunting OT - underweight OT - wasting COIS- The authors declared that they have no competing interests. EDAT- 2026/02/27 06:32 MHDA- 2026/03/07 01:37 PMCR- 2026/02/23 CRDT- 2026/02/27 01:17 PHST- 2025/12/22 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/01/18 00:00 [accepted] PHST- 2026/03/07 01:37 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 01:17 [entrez] PHST- 2026/02/23 00:00 [pmc-release] AID - nu18040709 [pii] AID - nutrients-18-00709 [pii] AID - 10.3390/nu18040709 [doi] PST - epublish SO - Nutrients. 2026 Feb 23;18(4):709. doi: 10.3390/nu18040709. PMID- 41754225 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 4 DP - 2026 Feb 23 TI - Validity of an AI-Assisted Dietary Recording Application for Family-Based Nutritional Management in Young Patients with Anorexia Nervosa. LID - 10.3390/nu18040708 [doi] LID - 708 AB - Background: Evidence regarding the validity of digital dietary recordings in the family-based nutritional management of anorexia nervosa (AN) remains limited. This study evaluated the validity of an AI-assisted dietary recording application (app) used by the parents of young patients with AN, with total energy intake as the primary outcome and major nutrient intake as the secondary outcome. Methods: During hospital leave prior to discharge, one day of dietary intake was recorded by parents using the app based on meal photographs. The energy and nutrient intakes estimated by the app were compared with a registered dietitian using visual estimation of the photographs. Differences were examined using the Wilcoxon signed-rank test, associations were assessed using Spearman's correlation coefficients, and agreement was evaluated using Bland-Altman analysis. Sensitivity analyses excluding extreme outliers were performed. Results: Thirty female inpatients with AN (mean age: 14.8 +/- 2.9 years) and their mothers participated. The median total energy intake did not differ significantly between the app and reference method (2462 vs. 2439 kcal/day). Moderate to high correlations were observed for total energy (rho = 0.62) and major nutrient intakes. The app tended to overestimate these intakes; however, Bland-Altman analyses indicated no systematic bias. Exclusion of two outliers strengthened correlations for total energy intake (rho = 0.74) and narrowed the limits of agreement. Conclusions: The app demonstrated an acceptable agreement for estimating energy and major nutrient intake in the therapeutic context of AN. Careful attention to dish type and portion size may further support its clinical use. FAU - Shiraishi, Nao AU - Shiraishi N AUID- ORCID: 0000-0003-4089-1816 AD - Department of Psychiatry and Cognitive-Behavioral Medicine, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. FAU - Kawase, Rieko AU - Kawase R AD - Clinical Nutritional Management Unit, Nagoya City University Hospital, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. FAU - Ogawa, Haruka AU - Ogawa H AD - Department of Psychiatry and Cognitive-Behavioral Medicine, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. FAU - Akechi, Tatsuo AU - Akechi T AD - Department of Psychiatry and Cognitive-Behavioral Medicine, Graduate School of Medical Sciences, Nagoya City University, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601, Japan. LA - eng GR - 23K02964/a Grant-in-Aid for Scientific Research from the Japanese Ministry of Education, Science, and Technology/ PT - Journal Article PT - Validation Study DEP - 20260223 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Anorexia Nervosa/diet therapy/therapy MH - Female MH - Adolescent MH - Energy Intake MH - *Diet Records MH - Reproducibility of Results MH - *Artificial Intelligence MH - *Mobile Applications MH - Nutrition Assessment MH - Intelligent Systems MH - Child PMC - PMC12942889 OTO - NOTNLM OT - artificial intelligence OT - caregivers OT - dietary assessment OT - eating disorders OT - mobile applications OT - nutrition therapy OT - validation study COIS- N.S. has received a lecture fee from Takeda. T.A. has received lectures fees from AstraZeneca, Chugai, Daiichi-Sankyo, Eisai, Eli-Lilly, Kowa, Lundbeck, MSD, Meiji-Seika Pharma, Merck, Otsuka, Pfizer, Shionogi, Sumitomo pharma, Takeda, Tsumura, UCB, and Viatris, a grant from Shinogi, and royalties from Igaku-Shoin outside the submitted work. T.A. serves as the representative director of the General Incorporated Association NCU CRESS and receives compensation as an advisor to Snom Inc. T.A. has pending patents (2020-135195, 2024-516288) (Institute) and the patent (7313617) (Institute). H.O. has received royalties from Igaku-Shoin. E.K. declares no conflicts of interest. The funder had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/02/27 06:31 MHDA- 2026/03/06 09:03 PMCR- 2026/02/23 CRDT- 2026/02/27 01:17 PHST- 2026/01/13 00:00 [received] PHST- 2026/02/10 00:00 [revised] PHST- 2026/02/19 00:00 [accepted] PHST- 2026/03/06 09:03 [medline] PHST- 2026/02/27 06:31 [pubmed] PHST- 2026/02/27 01:17 [entrez] PHST- 2026/02/23 00:00 [pmc-release] AID - nu18040708 [pii] AID - nutrients-18-00708 [pii] AID - 10.3390/nu18040708 [doi] PST - epublish SO - Nutrients. 2026 Feb 23;18(4):708. doi: 10.3390/nu18040708. PMID- 41754221 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 4 DP - 2026 Feb 22 TI - Skipping Breakfast and Lunch, as Well as Reducing Milk and Dairy Intake, Is Associated with Depressive Symptoms in Pregnant Adolescents. LID - 10.3390/nu18040704 [doi] LID - 704 AB - BACKGROUND AND OBJECTIVE: Depression is the most common mental health problem in women during pregnancy, associated with psychological, social, and medical factors characteristic of this stage. However, a lack of knowledge and limited attention to this condition can aggravate its consequences and restrict access to appropriate treatment. This research seeks to fill a gap in the scientific literature by exploring the association between eating habits and dietary diversity with depressive symptomatology in a group with high psychosocial vulnerability: pregnant adolescents. MATERIAL AND METHODS: A cross-sectional analytical study was conducted with a sample of 344 pregnant adolescents attending prenatal care at the National Institute of Perinatology (INPer), a tertiary care center. Non-probabilistic sampling was used for recruitment. Relevant information was collected using a pre-validated structured questionnaire administered via interview. Depressive symptomatology was assessed using the Edinburgh Postnatal Depression Scale (EPDS), with a score of >/=12 considered indicative of a higher risk of depression. Eating habits were evaluated based on meal omission, activities performed during meals, and dietary diversity, comparing them with national recommendations. Food group consumption was assessed using a semi-quantitative Food Frequency Questionnaire (FFQ). Robust variance Poisson regression models were employed to evaluate the independent association between undesirable eating habits, inadequate food group intake, and the presence of depressive symptomatology. RESULTS: A significant association was observed between the presence of depressive symptoms (EPDS >/= 12) and the omission of main meals. Specifically, skipping breakfast was associated with a higher prevalence of EPDS scores >/= 12 (aPR = 1.55; 95% CI: 1.10-2.19; p = 0.013). Similarly, adolescents who skipped lunch showed a higher prevalence of depressive symptomatology compared to those who did not (aPR = 2.02; 95% CI: 1.11-3.68; p = 0.022). Regarding food groups, only insufficient intake of milk and dairy products was significantly associated with the presence of depressive symptoms (aPR: 1.78; 95% CI: 1.16-2.73; p = 0.008). CONCLUSIONS: This cross-sectional study found a significant association between breakfast skipping, distraction while eating, and inadequate dairy intake with a higher prevalence of depressive symptoms in socially vulnerable pregnant adolescents treated at a tertiary care center. However, due to the study's design, causality or the direction of the relationship cannot be established (it could be bidirectional), and it cannot be affirmed that modifying the diet will necessarily reduce depression. Furthermore, the results are not generalizable to all pregnant adolescents, and future research (longitudinal or interventional) is needed to better understand these associations before developing specific dietary interventions. FAU - Samano, Reyna AU - Samano R AUID- ORCID: 0000-0001-5490-1363 AD - Coordinacion de Nutricion y Bioprogramacion, Instituto Nacional de Perinatologia, Secretaria de Salud, Montes Urales 800, Lomas de Virreyes, Alcaldia Miguel Hidalgo, Mexico City 11000, Mexico. FAU - Aguirre-Minutti, Estefania AU - Aguirre-Minutti E AUID- ORCID: 0000-0002-4951-8121 AD - Coordinacion de Nutricion y Bioprogramacion, Instituto Nacional de Perinatologia, Secretaria de Salud, Montes Urales 800, Lomas de Virreyes, Alcaldia Miguel Hidalgo, Mexico City 11000, Mexico. AD - Escuela de Dietetica y Nutricion del ISSSTE, Callejon Via, Av. San Fernando No. 12, San Pedro Apostol, Tlalpan, Mexico City 14070, Mexico. FAU - Martinez-Rojano, Hugo AU - Martinez-Rojano H AD - Seccion de Posgrado e Investigacion de la Escuela Superior de Medicina del Instituto Politecnico Nacional, Plan de San Luis y Diaz Miron s/n, Colonia Casco de Santo Tomas, Alcaldia Miguel Hidalgo, Mexico City 11340, Mexico. FAU - Chico-Barba, Gabriela AU - Chico-Barba G AUID- ORCID: 0000-0002-5741-0241 AD - Coordinacion de Nutricion y Bioprogramacion, Instituto Nacional de Perinatologia, Secretaria de Salud, Montes Urales 800, Lomas de Virreyes, Alcaldia Miguel Hidalgo, Mexico City 11000, Mexico. FAU - Gamboa, Ricardo AU - Gamboa R AUID- ORCID: 0000-0001-9102-4240 AD - Departamento de Fisiologia, Instituto Nacional de Cardiologia "Ignacio Chavez", Mexico City 14080, Mexico. FAU - Hernandez-Chavez, Carmen AU - Hernandez-Chavez C AD - Departamento de Neurobiologia del Desarrollo, Instituto Nacional de Perinatologia, Secretaria de Salud, Montes Urales 800, Lomas de Virreyes, Alcaldia Miguel Hidalgo, Mexico City 11000, Mexico. FAU - Mendoza-Flores, Maria Eugenia AU - Mendoza-Flores ME AD - Coordinacion de Nutricion y Bioprogramacion, Instituto Nacional de Perinatologia, Secretaria de Salud, Montes Urales 800, Lomas de Virreyes, Alcaldia Miguel Hidalgo, Mexico City 11000, Mexico. FAU - Gonzalez-Medina, Erika AU - Gonzalez-Medina E AD - Escuela de Dietetica y Nutricion del ISSSTE, Callejon Via, Av. San Fernando No. 12, San Pedro Apostol, Tlalpan, Mexico City 14070, Mexico. FAU - Perez-Romero, Primavera AU - Perez-Romero P AD - Escuela de Dietetica y Nutricion del ISSSTE, Callejon Via, Av. San Fernando No. 12, San Pedro Apostol, Tlalpan, Mexico City 14070, Mexico. LA - eng GR - SECTEI/147/2024, registration 3602c24./Secretariat of Education, Science, Technology and Innovation of Mexico City (SECTEI) 2024/ PT - Journal Article DEP - 20260222 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adolescent MH - Pregnancy MH - Cross-Sectional Studies MH - *Depression/epidemiology/etiology/psychology MH - *Breakfast/psychology MH - Animals MH - *Feeding Behavior/psychology MH - *Dairy Products MH - *Lunch/psychology MH - Milk MH - Intermittent Fasting MH - *Diet PMC - PMC12943198 OTO - NOTNLM OT - adolescent pregnancy OT - depression OT - depressive symptoms OT - eating habits OT - mental health OT - skipping breakfast COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/27 06:32 MHDA- 2026/03/08 01:38 PMCR- 2026/02/22 CRDT- 2026/02/27 01:17 PHST- 2026/01/19 00:00 [received] PHST- 2026/02/14 00:00 [revised] PHST- 2026/02/17 00:00 [accepted] PHST- 2026/03/08 01:38 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 01:17 [entrez] PHST- 2026/02/22 00:00 [pmc-release] AID - nu18040704 [pii] AID - nutrients-18-00704 [pii] AID - 10.3390/nu18040704 [doi] PST - epublish SO - Nutrients. 2026 Feb 22;18(4):704. doi: 10.3390/nu18040704. PMID- 41754177 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 4 DP - 2026 Feb 17 TI - A Maturation-Aware Machine Learning Framework for Screening the Nutritional Status of Adolescents. LID - 10.3390/nu18040660 [doi] LID - 660 AB - Background: Malnutrition in adolescents remains a significant public health issue worldwide, with undernutrition and overweight often coexisting. Accurate nutritional screening during adolescence is complicated by variability in biological maturation and class imbalance, particularly among underweight adolescents. Objective: This study aims to develop and validate machine learning models for classifying the nutritional status of adolescents, accounting for class imbalance and biological maturation, and to evaluate model stability and variable importance at different stages of peak height velocity (PHV). Methods: In this cross-sectional study, 4232 adolescents aged 11 to 18 years were recruited from nine educational institutions in Tunisia. Their nutritional status was classified according to the International Obesity Task Force (IOTF) BMI thresholds into three categories: underweight (14.4%), normal weight (68.3%), and overweight (17.2%). Ten anthropometric, behavioral, and maturation-related predictors were analyzed. Six supervised machine learning algorithms were evaluated using a 70/30 stratified split between training and test sets, with five-fold cross-validation. Class imbalance was addressed by ROSE combined with cost-sensitive learning. Model performance was assessed using accuracy, Cohen's kappa coefficient, macro F1 score, sensitivity, specificity, and AUC. Results: The cost-sensitive Random Forest (RF) model achieved the best overall performance, with an accuracy of 0.830, a macro F1 score of 0.767, a macro-AUC of 0.921, and a macro- sensitivity of 0.743. The class-specific sensitivities were 0.70 (underweight), 0.91 (normal weight), and 0.62 (overweight), with no major misclassification between the extreme categories. Performance remained stable across the different maturation phases (accuracy from 0.823 to 0.839), with optimal discrimination in the pre-PHV (macro-AUC = 0.936; sensitivity for underweight = 0.82) and post-PHV (macro-AUC = 0.931) periods. Body mass was the main predictor (importance = 1.00), followed by waist circumference (0.34-0.53). The importance of age for classifying underweight increased significantly from the pre-PHV (0.10) to the post-PHV (0.75) period. A two-stage hierarchical model further improved underweight detection (stage 1 AUC = 0.911; sensitivity = 0.732). Conclusions: A cost-sensitive RF model, combined with ROSE, provides robust classification of adolescents' nutritional status maturation, significantly improving underweight detection while preserving overall accuracy. This approach is particularly well-suited to public health screening in schools as a first-stage assessment that requires clinical confirmation and promotes a maturation-aware interpretation of nutritional risk among adolescents. FAU - Ghouili, Hatem AU - Ghouili H AD - Research Unit: Sports Science, Health and Movement, High Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef 7100, Tunisia. FAU - Farhani, Zouhaier AU - Farhani Z AD - Research Unit: Sports Science, Health and Movement, High Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef 7100, Tunisia. FAU - Yousfi, Narimen AU - Yousfi N AUID- ORCID: 0000-0002-2507-0553 AD - Research Unit: Sports Science, Health and Movement, High Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef 7100, Tunisia. FAU - Ceylan, Halil Ibrahim AU - Ceylan HI AUID- ORCID: 0009-0005-2214-4667 AD - Physical Education and Sports Teaching Department, Faculty of Sports Sciences, Ataturk University, Erzurum 25240, Turkiye. FAU - Dridi, Amel AU - Dridi A AD - Research Unit: Sports Science, Health and Movement, High Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef 7100, Tunisia. FAU - de Giorgio, Andrea AU - de Giorgio A AUID- ORCID: 0000-0001-6064-5634 AD - Artificial Engineering, 80121 Naples, Italy. FAU - Bragazzi, Nicola Luigi AU - Bragazzi NL AUID- ORCID: 0000-0001-8409-868X AD - Laboratory for Industrial and Applied Mathematics (LIAM), Department of Mathematics and Statistics, York University, Toronto, ON M3J 1P3, Canada. AD - Human Nutrition Unit (HNU), Department of Food and Drugs, University of Parma, 43121 Parma, Italy. AD - Department of Clinical Pharmacy, Saarland University, 66123 Saarbrucken, Germany. FAU - Guelmami, Noomen AU - Guelmami N AUID- ORCID: 0000-0002-4959-9726 AD - Research Unit: Sports Science, Health and Movement, High Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef 7100, Tunisia. FAU - Dergaa, Ismail AU - Dergaa I AUID- ORCID: 0000-0001-8091-1856 AD - Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Manouba 2010, Tunisia. AD - Physical Activity Research Unit, Sport and Health (UR18JS01), National Observatory of Sports, Tunis 1003, Tunisia. FAU - Bouassida, Anissa AU - Bouassida A AD - Research Unit: Sports Science, Health and Movement, High Institute of Sport and Physical Education of Kef, University of Jendouba, El Kef 7100, Tunisia. LA - eng PT - Journal Article DEP - 20260217 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Nutritional Status MH - Adolescent MH - Child MH - Cross-Sectional Studies MH - *Machine Learning MH - Random Forest MH - Female MH - Male MH - *Malnutrition/diagnosis MH - Classification Algorithms MH - Tunisia MH - Thinness/diagnosis MH - *Nutrition Assessment MH - Predictive Learning Models MH - *Mass Screening/methods MH - Body Mass Index MH - Overweight/diagnosis PMC - PMC12943452 OTO - NOTNLM OT - adolescent nutrition OT - biological maturation OT - class imbalance OT - machine learning OT - peak height velocity OT - random forest OT - underweight COIS- A.d.G. is the owner and CEO of Artificial Engineering. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/27 06:31 MHDA- 2026/03/06 09:08 PMCR- 2026/02/17 CRDT- 2026/02/27 01:17 PHST- 2025/12/27 00:00 [received] PHST- 2026/02/08 00:00 [revised] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/03/06 09:08 [medline] PHST- 2026/02/27 06:31 [pubmed] PHST- 2026/02/27 01:17 [entrez] PHST- 2026/02/17 00:00 [pmc-release] AID - nu18040660 [pii] AID - nutrients-18-00660 [pii] AID - 10.3390/nu18040660 [doi] PST - epublish SO - Nutrients. 2026 Feb 17;18(4):660. doi: 10.3390/nu18040660. PMID- 41754147 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 4 DP - 2026 Feb 14 TI - Associations Between Restrained, Emotional, and External Eating Behaviors and Obesity Among Saudi Adults: A Cross-Sectional Study. LID - 10.3390/nu18040631 [doi] LID - 631 AB - BACKGROUND AND AIM: Obesity has reached alarming levels globally and across the Middle East. In Saudi Arabia, approximately one-third of Saudi adults have obesity, representing a major public health concern. Understanding behavioral factors underlying obesity is essential; therefore, this study aimed to investigate the association between eating styles and obesity indicators among Saudi adults and to examine gender differences in these associations. METHODS: This cross-sectional study included 997 adult (405 males and 592 females) aged >/= 18 years residing in Saudi Arabia. Data were collected using a self-administered questionnaire covering sociodemographic characteristics, anthropometric measures, health status. Eating behaviors were assessed using the validated Dutch Eating Behavior Questionnaire (DEBQ), which measures restrained, emotional, and external eating styles. Regression models were used to examine gender differences in mean eating style scores and to assess associations between eating styles, categorical BMI, and body fatness. RESULTS: The mean age of participants was 37.05 +/- 13.39 years. Significant gender differences were observed in BMI, body fatness, and physical activity levels. Females demonstrated higher restrained eating scores compared with males (beta = -0.14; 95% CI: -0.24, -0.04; p = 0.008). Participants with obesity exhibited higher emotional eating scores, while external eating was more prevalent among underweight participants. Body fatness was significantly associated with emotional and external eating but not restrained eating. CONCLUSIONS: BMI status appears to be associated with specific eating styles, particularly unhealthy eating behaviors. These findings highlight the importance of behavioral-focused nutritional interventions that support eating regulation rather than emphasizing weight loss alone. FAU - Almaghrabi, Merfat Abdulrahman AU - Almaghrabi MA AUID- ORCID: 0000-0001-5521-4987 AD - Food and Nutrition Department, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. FAU - Bawajeeh, Areej AU - Bawajeeh A AD - Food and Nutrition Department, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. FAU - Shatwan, Israa M AU - Shatwan IM AUID- ORCID: 0000-0003-0222-9135 AD - Food and Nutrition Department, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. FAU - Malibary, Manal AU - Malibary M AUID- ORCID: 0000-0003-3611-9583 AD - Food and Nutrition Department, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. AD - Food, Nutrition and Lifestyle Unit, King Fahd Medical Research Center, King Abdulaziz University, Jeddah 3270, Saudi Arabia. FAU - Alzhrani, Shahad AU - Alzhrani S AD - Food and Nutrition Department, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. FAU - Alamoudi, Nouf AU - Alamoudi N AD - Food and Nutrition Department, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. FAU - Almadani, Jena AU - Almadani J AD - Food and Nutrition Department, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. FAU - Albar, Salwa AU - Albar S AUID- ORCID: 0000-0002-7559-6908 AD - Food and Nutrition Department, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. LA - eng GR - IPP: 1438-253-2025/Deanship of Scientific Research (DSR) at King Abdulaziz University, Jeddah, Saudi Arabia/ PT - Journal Article DEP - 20260214 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Cross-Sectional Studies MH - Saudi Arabia/epidemiology MH - Female MH - *Obesity/psychology/epidemiology MH - Adult MH - *Feeding Behavior/psychology MH - Middle Aged MH - Emotional Eating MH - Body Mass Index MH - *Emotions MH - Surveys and Questionnaires MH - Young Adult MH - Sex Factors MH - Adolescent PMC - PMC12942921 OTO - NOTNLM OT - Saudi Arabia OT - emotional eating OT - external eating OT - obesity OT - restrained eating COIS- The authors declare no conflicts of interest. EDAT- 2026/02/27 06:32 MHDA- 2026/03/07 16:14 PMCR- 2026/02/14 CRDT- 2026/02/27 01:17 PHST- 2026/01/06 00:00 [received] PHST- 2026/02/07 00:00 [revised] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/03/07 16:14 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 01:17 [entrez] PHST- 2026/02/14 00:00 [pmc-release] AID - nu18040631 [pii] AID - nutrients-18-00631 [pii] AID - 10.3390/nu18040631 [doi] PST - epublish SO - Nutrients. 2026 Feb 14;18(4):631. doi: 10.3390/nu18040631. PMID- 41754141 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 4 DP - 2026 Feb 13 TI - Long-Term Associations of Early-Life Human Milk Oligosaccharide Intake with Allergic Disease Development and Gut Microbiota Profiles in 5-Year-Old Children. LID - 10.3390/nu18040624 [doi] LID - 624 AB - Background: Based on our extensive cohort study, the Maternal Nutrition and Infant Investigation (MUAI), this research investigated the associations between human milk oligosaccharide (HMO) intake during the postnatal period and allergic disease development and gut microbiome composition in early childhood through long-term follow-up. Methods: Human breast milk (HBM) samples at five lactation stages and fecal samples of infants and young children were collected. Children aged 5 years included in this study were categorized into allergic and non-allergic groups via standardized allergen testing. Results: The findings indicated that higher HMO intake levels across five distinct lactation periods may be linked to a reduced incidence of allergies in children. The consumption of six major structurally representative HMOs was significantly associated with alterations in the gut microbiota profiles of young children. Moreover, there were notable differences in gut microbiota composition between allergic and non-allergic children. Specifically, beneficial bacteria such as Bifidobacterium, Akkermansia, and Ruminococcus were significantly enriched, in addition to the levels of metabolite propionic acid, a beneficial short-chain fatty acid, which were notably higher in the non-allergic group. To further validate the relationship between Bifidobacterium abundance and early HMO intake, the analysis revealed that a differential strain biomarker, Bifidobacterium adolescentis (B. adolescentis), exhibited significant correlations with specific HMOs at different lactation stages, particularly showing a strong positive correlation with 2'-fucosyllactose (2'-FL) content. Conclusions: These findings suggest that early-life HMO intake is associated with long-term differences in allergic outcomes, potentially through modulation of gut microbiota composition, particularly the enrichment of B. adolescentis. FAU - Kou, Ruixin AU - Kou R AUID- ORCID: 0009-0005-1613-2360 AD - Key Laboratory of Special Diet Nutrition and Health Research of China National Light Industry Council, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. FAU - Pan, Che AU - Pan C AD - Abbott Nutrition Research & Development Center, Shanghai 200233, China. FAU - Xing, Xiaolong AU - Xing X AD - Key Laboratory of Special Diet Nutrition and Health Research of China National Light Industry Council, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. FAU - Wang, Jin AU - Wang J AUID- ORCID: 0000-0002-3312-8831 AD - Key Laboratory of Special Diet Nutrition and Health Research of China National Light Industry Council, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. FAU - Morrin, Sinead T AU - Morrin ST AD - Abbott Nutrition Research & Development Center, Columbus, OH 43215, USA. FAU - Buck, Rachael H AU - Buck RH AUID- ORCID: 0009-0008-0609-6900 AD - Abbott Nutrition Research & Development Center, Columbus, OH 43215, USA. FAU - Li, Xiang AU - Li X AD - Abbott Nutrition Research & Development Center, Singapore 138668, Singapore. FAU - Mao, Yingyi AU - Mao Y AD - Abbott Nutrition Research & Development Center, Shanghai 200233, China. FAU - Wang, Shuo AU - Wang S AD - Key Laboratory of Special Diet Nutrition and Health Research of China National Light Industry Council, School of Medicine, Nankai University, Tianjin 300071, China. AD - Research Institute of Public Health, Nankai University, Tianjin 300071, China. LA - eng PT - Journal Article DEP - 20260213 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Oligosaccharides) SB - IM MH - Humans MH - *Milk, Human/chemistry MH - *Oligosaccharides/administration & dosage MH - Child, Preschool MH - *Gastrointestinal Microbiome MH - Female MH - *Hypersensitivity/microbiology/epidemiology/prevention & control MH - Feces/microbiology MH - Infant MH - Male MH - Lactation PMC - PMC12943307 OTO - NOTNLM OT - Bifidobacterium adolescentis OT - allergic disease OT - gut microbiota OT - human milk oligosaccharides OT - short-chain fatty acids COIS- The authors declare no conflict of interest. C.P., S.T.M., R.H.B., X.L. and Y.M. were all employees of Abbott Nutrition Research & Development Center when this work was completed. The authors declare that this study received funding from the Abbott Nutrition Research and Development (R&D) Centre, Shanghai, China. The funder was not involved in the study design, collection, analysis, interpretation of data, the writing of this article, or the decision to submit it for publication. EDAT- 2026/02/27 06:32 MHDA- 2026/03/06 08:57 PMCR- 2026/02/13 CRDT- 2026/02/27 01:17 PHST- 2025/12/22 00:00 [received] PHST- 2026/02/07 00:00 [revised] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/03/06 08:57 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 01:17 [entrez] PHST- 2026/02/13 00:00 [pmc-release] AID - nu18040624 [pii] AID - nutrients-18-00624 [pii] AID - 10.3390/nu18040624 [doi] PST - epublish SO - Nutrients. 2026 Feb 13;18(4):624. doi: 10.3390/nu18040624. PMID- 41753197 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260227 LR - 20260813 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 4 DP - 2026 Feb 14 TI - Video and Wearable Sensor Technologies for Early Detection of Cerebral Palsy in Infants: A Scoping Review. LID - 10.3390/jcm15041510 [doi] LID - 1510 AB - It is well established that early diagnosis and subsequent intervention can result in significant benefits in infants with neurodevelopmental disorders such as cerebral palsy (CP). This scoping review aimed to assess the current state of the literature regarding the use of innovative and emerging technologies for early CP screening, diagnosis and phenotyping in pre-ambulatory children. Searches were performed across PubMed, Embase and Cochrane databases; articles were screened by four independent reviewers at the title/abstract and full-text levels. Forty-eight studies met the inclusion criteria. The most frequently used modalities included wearable sensors (e.g., accelerometers, inertial measurement units) and video-based motion analysis. These movement-tracking systems were used to screen for a variety of pediatric-onset neurodevelopmental disorders and have been useful in quantifying spontaneous infant movements, detecting the absence or abnormality of fidgety movement, or identifying atypical motor patterns. Although CP was our primary focus, several studies applied a similar pipeline to autism spectrum disorder (ASD) and spinal muscular atrophy (SMA), underscoring broader relevance for early neurodevelopmental screening, diagnosing and phenotyping. Overall, technology-assisted motor assessment demonstrated promising feasibility and diagnostic potential; however, most studies are limited by small sample sizes, short follow-up durations, and heterogeneous validation methods. Given the benefits of early intervention and the emerging capabilities of wearable and video-based analytics, larger multi-site and longitudinal datasets are needed to support early diagnosis, risk stratification, and functional phenotyping in CP. FAU - Wahle, Charlotte F AU - Wahle CF AUID- ORCID: 0000-0001-5928-9484 AD - David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. FAU - Elias, Aura M AU - Elias AM AD - David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. FAU - Galoustian, Nora A AU - Galoustian NA AUID- ORCID: 0000-0003-4683-0862 AD - David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA. FAU - Tee, Teana M AU - Tee TM AUID- ORCID: 0009-0002-1353-4004 AD - Herbert Wertheim College of Medicine, Miami, FL 33199, USA. FAU - Juels, Michaela L AU - Juels ML AD - Department of Orthopaedic Surgery, University of California, San Francisco, CA 94143, USA. FAU - Amacker, Christine AU - Amacker C AD - Department of Orthopaedic Surgery, Rady Children's Hospital, San Diego, CA 92123, USA. FAU - Waters, Heather AU - Waters H AD - Department of Orthopaedic Surgery, Rady Children's Hospital, San Diego, CA 92123, USA. FAU - Thompson, Rachel M AU - Thompson RM AD - Department of Orthopaedic Surgery, Rady Children's Hospital, San Diego, CA 92123, USA. AD - Department of Orthopaedic Surgery, University of California, San Diego, CA 92037, USA. LA - eng PT - Journal Article PT - Review DEP - 20260214 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC12941449 OTO - NOTNLM OT - General Movements Assessment OT - accelerometry OT - cerebral palsy OT - deep learning OT - motion sensor OT - pre-ambulatory COIS- R.T. is a paid educational consultant for Arthrex. All other authors report no relevant disclosures. EDAT- 2026/02/27 06:32 MHDA- 2026/02/27 06:33 PMCR- 2026/02/14 CRDT- 2026/02/27 01:14 PHST- 2025/12/22 00:00 [received] PHST- 2026/02/01 00:00 [revised] PHST- 2026/02/08 00:00 [accepted] PHST- 2026/02/27 06:33 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 01:14 [entrez] PHST- 2026/02/14 00:00 [pmc-release] AID - jcm15041510 [pii] AID - jcm-15-01510 [pii] AID - 10.3390/jcm15041510 [doi] PST - epublish SO - J Clin Med. 2026 Feb 14;15(4):1510. doi: 10.3390/jcm15041510. PMID- 41752690 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 62 IP - 2 DP - 2026 Feb 1 TI - The Cut-Off for Triglyceride-Glucose-Body Mass Index (TyG-BMI) and Triglyceride-Glucose-Waist Circumference Index (TyG-WC) Discriminating the Insulin Resistance Based on the SHBG Level and HOMA-IR Value in Caucasian Women with Polycystic Ovary Syndrome. LID - 10.3390/medicina62020291 [doi] LID - 291 AB - Background and Objectives: Cut-off points for the triglyceride-glucose-body mass index (TyG-BMI) and the triglyceride-glucose-waist circumference index (TyG-WC) have been established for the assessment of insulin resistance (IR) only in the population of Asian women with polycystic ovary syndrome (PCOS). Therefore, the present study aimed to estimate the cut-off value for these indices discriminating the IR based on the homeostatic model assessment for insulin resistance (HOMA-IR) and sex hormone binding globulin (SHBG) levels established previously in Caucasian women with PCOS. Material and Methods: The medical records of 264 selected young adults (18-40 y.o.) Caucasian women with PCOS were the source of parameters: age, body weight, height, waist circumference, glucose, insulin, triglyceride, and SHBG levels, used for calculation of TyG-BMI and TyG-WC indices. The cut-off values for TyG-BMI and TyG-WC indices were calculated using receiver operating characteristic curve analysis. Results: The study group included 68 overweight (25.8%) and 62 overweight (23.4%) women. The empirical optimal cut-off values for TyG-BMI and TyG-WC indices corresponding to HOMA-IR values >/= 2.1 were 233 and 735 [area under the curve (AUC) 85.1% and 86.7%, accuracy 0.814 and 0.784, sensitivity 66.3% and 67.3%, specificity 90.4% and 84.9%, PPV 80.2% and 72.5%, NPV 82.0% and 81.5%], respectively. The empirical optimal cut-off values for TyG-BMI and TyG-WC indices corresponding to SHBG levels < 41.5 nmol/L were 230 and 734 (AUC 79.5% and 77.1%, accuracy 0.735 and 0.723, Se 57.4% and 57.4%, Sp 87.3% and 85.2%, PPV 79.5% and 76.9%, NPV 70.4% and 69.9%), respectively. Conclusions: The cut-offs for the TyG-BMI and TyG-WC indices discriminating IR in young Caucasian women with PCOS were similar regardless of whether they are based on HOMA-IR values or SHBG levels. FAU - Rhaiem, Tahar Ben AU - Rhaiem TB AD - Department of Gynecological Endocrinology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-055 Katowice, Poland. FAU - Owczarek, Aleksander Jerzy AU - Owczarek AJ AUID- ORCID: 0000-0003-1179-6932 AD - Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-055 Katowice, Poland. FAU - Wojtowicz, Mariusz AU - Wojtowicz M AD - Clinical Department of Gynecology and Obstetrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, 40-055 Katowice, Poland. FAU - Ciura, Dariusz AU - Ciura D AUID- ORCID: 0000-0003-1463-8040 AD - Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-055 Katowice, Poland. FAU - Madej, Pawel AU - Madej P AD - Department of Gynecological Endocrinology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-055 Katowice, Poland. FAU - Olszanecka-Glinianowicz, Magdalena AU - Olszanecka-Glinianowicz M AUID- ORCID: 0000-0001-5632-5590 AD - Health Promotion and Obesity Management Unit, Department of Pathophysiology, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-055 Katowice, Poland. FAU - Chudek, Jerzy Tadeusz AU - Chudek JT AUID- ORCID: 0000-0002-6367-7794 AD - Department of Internal Medicine and Oncological Chemotherapy, Faculty of Medical Sciences in Katowice, Medical University of Silesia in Katowice, 40-055 Katowice, Poland. LA - eng PT - Journal Article DEP - 20260201 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 RN - 0 (Triglycerides) RN - 0 (Sex Hormone-Binding Globulin) RN - 0 (Blood Glucose) SB - IM MH - Humans MH - Female MH - *Insulin Resistance/physiology MH - *Triglycerides/blood/analysis MH - *Sex Hormone-Binding Globulin/analysis MH - Body Mass Index MH - *Polycystic Ovary Syndrome/blood/physiopathology/complications MH - Adult MH - *Waist Circumference/physiology MH - *Blood Glucose/analysis MH - Adolescent MH - White People/statistics & numerical data MH - Young Adult MH - ROC Curve PMC - PMC12941895 OTO - NOTNLM OT - PCOS OT - TyG-BMI index OT - TyG-WC index OT - glucose OT - insulin resistance OT - lipids COIS- The authors declare no conflicts of interest. EDAT- 2026/02/27 06:31 MHDA- 2026/03/06 09:11 PMCR- 2026/02/01 CRDT- 2026/02/27 01:12 PHST- 2026/01/07 00:00 [received] PHST- 2026/01/29 00:00 [revised] PHST- 2026/01/29 00:00 [accepted] PHST- 2026/03/06 09:11 [medline] PHST- 2026/02/27 06:31 [pubmed] PHST- 2026/02/27 01:12 [entrez] PHST- 2026/02/01 00:00 [pmc-release] AID - medicina62020291 [pii] AID - medicina-62-00291 [pii] AID - 10.3390/medicina62020291 [doi] PST - epublish SO - Medicina (Kaunas). 2026 Feb 1;62(2):291. doi: 10.3390/medicina62020291. PMID- 41752646 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260825 IS - 1648-9144 (Electronic) IS - 1010-660X (Print) IS - 1010-660X (Linking) VI - 62 IP - 2 DP - 2026 Jan 24 TI - Mass Screening Strategies for Celiac Disease in Apparently Healthy Children and Adolescents: A Systematic Review. LID - 10.3390/medicina62020246 [doi] LID - 246 AB - Background and Objectives: Celiac disease (CD) is a major global public health problem that can occur at any age. Pediatric CD can be typical, atypical, or even asymptomatic. Early diagnosis and early initiation of treatment are essential for improving patients' quality of life and preventing serious complications later in life. However, it is impossible to identify asymptomatic children and adolescents without screening. In this systematic review, we attempted to identify different mass screening programs that have been reported for CD in apparently healthy children and adolescents across the world, to highlight the advantages and disadvantages of such strategies, and to collect and synthesize data from these studies reporting the prevalence of CD. In addition, where data were available, we also attempted to evaluate the diagnostic accuracy of the tests used, their cost-effectiveness, the reported clinical benefits, and follow-up data from individuals identified through screening. Materials and Methods: Electronic databases, including PubMed and Scopus, were systematically searched. Initially, a total of 316 studies were retrieved. Finally, 55 studies met all inclusion criteria and were included in this review. The included studies were published between 1996 and 2023. Results: The reported age of participants ranged from 6 months to 23 years. Confirmation of CD by biopsy was reported in all but six studies. According to the studies that provided data, the (tTG IgA) seroprevalence of CD in apparently healthy children and adolescents, detected through different mass screening methods around the world, ranged from 0.20% (Turkey) to 3.11% (Italy). In addition, the prevalence of biopsy-confirmed CD ranged from 0.036% (Vietnam) to 3% (Sweden and Spain). Studies from 17 countries reported mass screening strategies based on finger-prick rapid tests. All rapid tests detected CD antibodies, except two, which detected HLA DQ2/DQ8 haplotypes. Rapid tests appeared to be no less sensitive and specific than other screening tests for CD and were probably less expensive, but further studies are needed for more reliable conclusions. Of the 55 studies in the review, only 10 reported follow-up data. After 3 months of a gluten-free diet, the general condition of the patients improved; after 6 months, tTG IgA and EMA IgA levels decreased and hemoglobin values increased; while after 1 year, tTG IgG levels also decreased, symptoms subsided, the children's weight and height increased, school performance improved, episodes of upper respiratory tract infections decreased, and thyreoperoxidase antibodies that were positive at screening became negative. Conclusions: Mass screening for CD in asymptomatic children and adolescents is a challenge. Future research should provide more answers regarding the most appropriate target age, the frequency of screening, the optimal screening method, the cost-effectiveness, the clinical utility, and the long-term impact of mass screening on patients' quality of life. FAU - Mpakosi, Alexandra AU - Mpakosi A AUID- ORCID: 0000-0002-9833-8477 AD - Department of Immunology, General Hospital of Nikaia "Agios Panteleimon", 18454 Piraeus, Greece. FAU - Cholevas, Vasileios AU - Cholevas V AD - School of Medicine, University of Bologna, 40126 Bologna, Italy. FAU - Tsantes, Andreas G AU - Tsantes AG AUID- ORCID: 0000-0002-3695-0759 AD - Department of Microbiology, Saint Savvas Oncology Hospital, 11522 Athens, Greece. FAU - Pastrikou, Argyro AU - Pastrikou A AD - Department of Immunology, General Hospital of Nikaia "Agios Panteleimon", 18454 Piraeus, Greece. FAU - Fragkiadaki, Aikaterini AU - Fragkiadaki A AD - Department of Immunology, General Hospital of Nikaia "Agios Panteleimon", 18454 Piraeus, Greece. FAU - Zhgabi, Sofia AU - Zhgabi S AD - Department of Biology, School of Medicine, National and Kapodistrian University of Athens, 11527 Athens, Greece. FAU - Mougiou, Vasiliki AU - Mougiou V AUID- ORCID: 0009-0007-1403-143X AD - Neonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece. FAU - Iacovidou, Nicoletta AU - Iacovidou N AUID- ORCID: 0000-0001-8021-6191 AD - Neonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece. FAU - Sokou, Rozeta AU - Sokou R AUID- ORCID: 0000-0002-9972-8901 AD - Neonatal Department, Aretaieio Hospital, National and Kapodistrian University of Athens, 11528 Athens, Greece. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260124 PL - Switzerland TA - Medicina (Kaunas) JT - Medicina (Kaunas, Lithuania) JID - 9425208 RN - 0 (Autoantibodies) RN - 0 (Immunoglobulin A) RN - EC 2.3.2.13 (Transglutaminases) SB - IM MH - Humans MH - *Celiac Disease/diagnosis/epidemiology MH - Adolescent MH - *Mass Screening/methods/standards MH - Child MH - Child, Preschool MH - Autoantibodies/blood MH - Prevalence MH - Immunoglobulin A/blood/analysis MH - Infant MH - Transglutaminases PMC - PMC12942272 OTO - NOTNLM OT - celiac disease OT - gluten free diet OT - point of care test OT - rapid test OT - screening COIS- The authors declare no conflicts of interest. EDAT- 2026/02/27 06:31 MHDA- 2026/03/06 09:10 PMCR- 2026/01/24 CRDT- 2026/02/27 01:12 PHST- 2025/12/30 00:00 [received] PHST- 2026/01/20 00:00 [revised] PHST- 2026/01/22 00:00 [accepted] PHST- 2026/03/06 09:10 [medline] PHST- 2026/02/27 06:31 [pubmed] PHST- 2026/02/27 01:12 [entrez] PHST- 2026/01/24 00:00 [pmc-release] AID - medicina62020246 [pii] AID - medicina-62-00246 [pii] AID - 10.3390/medicina62020246 [doi] PST - epublish SO - Medicina (Kaunas). 2026 Jan 24;62(2):246. doi: 10.3390/medicina62020246. PMID- 41751854 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 27 IP - 4 DP - 2026 Feb 10 TI - Wheat Allergy in the Era of Precision Medicine: From Novel Molecular Markers to New Therapeutic Perspectives. LID - 10.3390/ijms27041717 [doi] LID - 1717 AB - Wheat allergy (WA) poses a diagnostic challenge due to its diverse clinical phenotypes-ranging from classic food allergy and wheat-dependent exercise-induced anaphylaxis (WDEIA) to baker's asthma. An additional diagnostic aspect is serological cross-reactivity with grass pollen. Undoubtedly, the transition from extract-based diagnostics to precise component-based diagnostics (CRDs) facilitates the management of wheat allergy. It has significantly improved the diagnostic accuracy for WDEIA omega-5-gliadin (Tri a 19), although considering new knowledge about wheat proteins, it seems necessary to include them in the diagnostic scheme, especially where Tri a 19 remains negative despite clinical symptoms. Therefore, in this review, we evaluate the clinical utility of new wheat molecules with a high risk of anaphylaxis. We pay particular attention to Tri a 37 (alpha-purothionin), a thermally stable allergen associated with a 4-fold increase in the risk of severe anaphylaxis, and Tri a 36 (LMW glutenin), which shows higher sensitivity than Tri a 19 in specific pediatric cohorts. In addition, we emphasize the role of Tri a 14 (nsLTP) in distinguishing true wheat sensitization from pollen-related cross-reactivity caused by profilins (Tri a 12) or carbohydrate determinants (CCDs). Beyond diagnostics, the review discusses dynamic changes in sensitization profiles in relation to the allergic march and the phenomenon of spontaneous remission in children. New management strategies are also discussed, including the potential of omalizumab (based on the data from the OUtMATCH study) in facilitating the reintroduction of allergens into the diet. FAU - Pukalyak, Solomiya AU - Pukalyak S AUID- ORCID: 0009-0005-2134-8676 AD - Polish-Ukrainian Foundation for the Development of Medicine, Naleczowska 14, 20-701 Lublin, Poland. FAU - Gromek, Weronika AU - Gromek W AD - Polish-Ukrainian Foundation for the Development of Medicine, Naleczowska 14, 20-701 Lublin, Poland. FAU - Tomczak, Aleksandra AU - Tomczak A AD - Independent Public Healthcare Centre of the Ministry of Internal Affairs and Administration in Lublin, Grenadierow 3, 20-331 Lublin, Poland. FAU - Markut-Miotla, Ewa AU - Markut-Miotla E AD - Department of Allergology and Paediatry, Medical University of Lublin, Prof. Antoniego Gebali 6, 20-093 Lublin, Poland. FAU - Wozniak, Maja AU - Wozniak M AUID- ORCID: 0009-0009-7400-0170 AD - Polish-Ukrainian Foundation for the Development of Medicine, Naleczowska 14, 20-701 Lublin, Poland. FAU - Wysokinski, Mariusz AU - Wysokinski M AUID- ORCID: 0000-0001-8939-2490 AD - Department of Basic Nursing, Faculty of Health Sciences, Medical University of Lublin, Staszica 4/6, 20-081 Lublin, Poland. FAU - Smolinska, Sylwia AU - Smolinska S AUID- ORCID: 0000-0001-6736-2696 AD - Department of Clinical Immunology, Faculty of Medicine, Wroclaw Medical University, Parkowa 34, 51-616 Wroclaw, Poland. FAU - Majsiak, Emilia AU - Majsiak E AUID- ORCID: 0000-0003-3638-9292 AD - Health Promotion Department, Faculty of Health Sciences, Medical University of Lublin, Staszica 4/6, 20-081 Lublin, Poland. LA - eng PT - Journal Article PT - Review DEP - 20260210 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - 0 (Biomarkers) RN - 0 (Allergens) RN - 0 (Antigens, Plant) RN - 9007-90-3 (Gliadin) SB - IM MH - Humans MH - *Wheat Hypersensitivity/diagnosis/therapy/immunology MH - *Precision Medicine/methods MH - Biomarkers MH - Allergens/immunology MH - Anaphylaxis/immunology MH - Triticum/immunology MH - Antigens, Plant/immunology MH - Gliadin/immunology MH - Cross Reactions MH - Pollen/immunology PMC - PMC12940863 OTO - NOTNLM OT - Tri a 36 (LMW glutenin) OT - Tri a 37 (alpha-purothionin) OT - anaphylaxis OT - component-resolved diagnostics (CRDs) OT - omalizumab OT - wheat allergy COIS- The authors declare no conflicts of interest. EDAT- 2026/02/27 06:32 MHDA- 2026/03/07 16:15 PMCR- 2026/02/10 CRDT- 2026/02/27 01:09 PHST- 2026/01/04 00:00 [received] PHST- 2026/01/23 00:00 [revised] PHST- 2026/02/03 00:00 [accepted] PHST- 2026/03/07 16:15 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 01:09 [entrez] PHST- 2026/02/10 00:00 [pmc-release] AID - ijms27041717 [pii] AID - ijms-27-01717 [pii] AID - 10.3390/ijms27041717 [doi] PST - epublish SO - Int J Mol Sci. 2026 Feb 10;27(4):1717. doi: 10.3390/ijms27041717. PMID- 41750134 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260227 LR - 20260813 IS - 2076-3425 (Print) IS - 2076-3425 (Electronic) IS - 2076-3425 (Linking) VI - 16 IP - 2 DP - 2026 Jan 27 TI - Bounce-Based Aerobic Exercise Improves Postpartum Mood: A Large-Scale Pre-Post Study. LID - 10.3390/brainsci16020133 [doi] LID - 133 AB - Background: Postpartum mental health challenges are increasingly recognized as a major public health concern, particularly during the early months after childbirth when emotional vulnerability is heightened. Although aerobic exercise is known to be associated with mood improvement, few large-scale studies have examined the acute psychological effects of a single exercise session in postpartum women, especially in contexts where environmental barriers restrict opportunities for physical activity. Methods: A total of 628 postpartum mothers (2-6 months postpartum) residing in a snowbound region of northern Japan participated in a single-session indoor bounce-based aerobic exercise program. Mood states were assessed immediately before and after the session using the validated Japanese short-form Profile of Mood States (POMS). Open-ended comments were also collected and analyzed thematically. Results: Paired analyses demonstrated significant acute improvements in key mood domains. Tension-Anxiety decreased (mean difference -7.91, 95% CI [-8.82, -7.00]; d = -0.68), and Anger-Hostility decreased (-4.61, 95% CI [-5.40, -3.82]; d = -0.45), while Vigor increased (11.82, 95% CI [10.47, 13.17]; d = 0.69) (all p < 0.001). In contrast, Depression-Dejection showed no significant change (-0.33, 95% CI [-1.30, 0.64]; p = 0.613). Conclusions: A single session of indoor bounce-based aerobic exercise was associated with immediate improvements in emotional well-being among postpartum women, particularly in anxiety-related and activation-related mood states. Because this exercise modality can be performed safely at home and is well suited to regions where outdoor physical activity is restricted, it may represent an accessible strategy for supporting postpartum mental health. Future research should examine longitudinal effects, controlled designs, and optimal program frequency to determine sustained benefits. FAU - Torashima, Shizuka AU - Torashima S AUID- ORCID: 0000-0002-8706-2620 AD - Department of Health Sciences, Faculty of Human Sciences, Osaka International University, Osaka 570-8555, Japan. FAU - Fujibayashi, Sonoko AU - Fujibayashi S AD - Faculty of Psychology, Koshien University, Takarazuka 665-0006, Japan. FAU - Kishimoto, Naoko AU - Kishimoto N AUID- ORCID: 0009-0006-1431-5398 AD - Department of Health Sciences, Faculty of Human Sciences, Osaka International University, Osaka 570-8555, Japan. FAU - Samukawa, Mina AU - Samukawa M AUID- ORCID: 0000-0002-4663-598X AD - Faculty of Health Sciences, Hokkaido University, Sapporo 060-0812, Japan. LA - eng PT - Journal Article DEP - 20260127 PL - Switzerland TA - Brain Sci JT - Brain sciences JID - 101598646 PMC - PMC12938090 OTO - NOTNLM OT - Profile of Mood States (POMS) OT - aerobic exercise OT - bounce-based exercise OT - indoor exercise OT - perinatal mental health OT - physical activity OT - postpartum mental health OT - postpartum mood COIS- The authors declare no conflicts of interest. EDAT- 2026/02/27 06:32 MHDA- 2026/02/27 06:33 PMCR- 2026/01/27 CRDT- 2026/02/27 01:03 PHST- 2025/12/20 00:00 [received] PHST- 2026/01/09 00:00 [revised] PHST- 2026/01/21 00:00 [accepted] PHST- 2026/02/27 06:33 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 01:03 [entrez] PHST- 2026/01/27 00:00 [pmc-release] AID - brainsci16020133 [pii] AID - brainsci-16-00133 [pii] AID - 10.3390/brainsci16020133 [doi] PST - epublish SO - Brain Sci. 2026 Jan 27;16(2):133. doi: 10.3390/brainsci16020133. PMID- 41750077 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260227 LR - 20260813 IS - 2076-328X (Print) IS - 2076-328X (Electronic) IS - 2076-328X (Linking) VI - 16 IP - 2 DP - 2026 Feb 11 TI - Leveraging Student-Athlete Mental Health Through an AI-Augmented Mobile Platform: The ThriveNudge Study Protocol. LID - 10.3390/bs16020268 [doi] LID - 268 AB - Playing sports remains one of the most common avenues for youth engagement in physical activity. Yet mental health challenges, such as performance anxiety, depressive symptoms, reduced motivation, and burnout, place many young athletes at risk. As key mediators of sport participation, coaches' roles are often underscored in recognizing shifts in athlete motivation, behavior, or well-being. Gaining better insight into athlete mental health status may enable coaches to provide timely support and strengthen athlete and team well-being. In this study protocol, we employ a mixed-methods design, evaluating the effectiveness of an AI-augmented mobile application (i.e., ThriveNudge) in promoting the mental health of youth athletes. ThriveNudge helps coaches monitor athlete mental health, flag mood disruptions, and practice supportive communication via simulated chats. A target sample of four interscholastic teams (with athletes aged 14-18 years) and their head coaches will be recruited. Teams will be cluster-randomized to either the intervention condition (n = 2), receiving pre-season training to implement ThriveNudge, or to a waitlist control condition (n = 2). Primary outcomes, including athlete burnout, motivation, coach-athlete relationships, and sport enjoyment, will be measured using psychometric scales administered online. Semi-structured interviews will be conducted with coaches and athletes in the experimental group to collect qualitative data on user interface and user experience. We hypothesize that teams using ThriveNudge will report lower athlete anxiety and burnout, higher intrinsic motivation and enjoyment, and stronger coach-athlete relationships than athletes in control teams. We aim to provide a scalable and accessible digital platform that safeguards youth mental health. FAU - Chakraborty, Sameer AU - Chakraborty S AD - Paul G. Allen School of Computer Science and Engineering, University of Washington, Seattle, WA 98105, USA. FAU - Mendro, Nicholas AU - Mendro N AD - Arlington High School, Arlington, WA 98223, USA. AD - Center for Leadership in Athletics, College of Education, University of Washington, Seattle, WA 98105, USA. FAU - Li, Longxi AU - Li L AUID- ORCID: 0000-0001-7898-8838 AD - Center for Leadership in Athletics, College of Education, University of Washington, Seattle, WA 98105, USA. LA - eng PT - Journal Article DEP - 20260211 PL - Switzerland TA - Behav Sci (Basel) JT - Behavioral sciences (Basel, Switzerland) JID - 101576826 PMC - PMC12938559 OTO - NOTNLM OT - coach education OT - large language models OT - mHealth OT - mental health OT - physical activity OT - youth sport COIS- The authors declare no conflicts of interest. EDAT- 2026/02/27 06:31 MHDA- 2026/02/27 06:32 PMCR- 2026/02/11 CRDT- 2026/02/27 01:03 PHST- 2025/10/30 00:00 [received] PHST- 2026/01/02 00:00 [revised] PHST- 2026/01/31 00:00 [accepted] PHST- 2026/02/27 06:32 [medline] PHST- 2026/02/27 06:31 [pubmed] PHST- 2026/02/27 01:03 [entrez] PHST- 2026/02/11 00:00 [pmc-release] AID - bs16020268 [pii] AID - behavsci-16-00268 [pii] AID - 10.3390/bs16020268 [doi] PST - epublish SO - Behav Sci (Basel). 2026 Feb 11;16(2):268. doi: 10.3390/bs16020268. PMID- 41749663 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260227 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 2 DP - 2026 Feb 23 TI - Associations Between Body Mass Index, Movement Behaviors, Motor Skills, Inhibition and Visuospatial Working Memory in Preschool Children: A Cross-Sectional Study Based on WHO References. LID - 10.3390/children13020306 [doi] LID - 306 AB - BACKGROUND: Early childhood represents a key stage for the development of movement behaviors (MB), motor skills (MS), and executive functions (EF). Body Mass Index (BMI), defined according to World Health Organization (WHO) references, may influence these domains early in life. In this context, this cross-sectional observational study aimed to examine the associations between BMI and 24-h MB, MS, and EF in Tunisian preschool children aged 4 to 5 years. METHODS: This cross-sectional observational study included 112 Tunisian children aged 4 to 5 years (50 boys, 62 girls), recruited from kindergartens in urban and rural areas. Anthropometric measurements were used to calculate age-specific BMI z-scores and classify children into three BMI categories: below normal, normal, and above normal. Twenty-four-hour MB physical activity (PA), sedentary behavior (SB), and sleep were objectively assessed using accelerometry over five consecutive days. EF (inhibition and working memory) were assessed using standardized cognitive tests, gross MS were evaluated using the Supine Timed Up and Go test (functional mobility), One-Leg Standing Balance test (postural steadiness), Hand Grip Dynamometer (upper body strength), and Standing Long Jump (lower body strength), and fine MS were assessed using the 9-Hole Pegboard Test (dexterity). All tools are validated and standardized for children. RESULTS: Significant differences between BMI categories were observed for anthropometric variables (p < 0.05). In contrast, no significant differences were found for 24-h MB, adherence to recommendations, EF, and MS (p > 0.05). Only Sleep duration showed a difference significantly between BMI < normal and BMI > normal (p = 0.022). CONCLUSIONS: In Tunisian preschool children, weight status is primarily associated with differences in physical growth, with no marked relationship to MB, EF, or MS. These findings highlight the importance of universal preventive interventions, particularly focusing on growth monitoring, starting in early childhood. These results should be interpreted with caution and highlight the need for further studies on larger populations to better understand the relationships between BMI, PA, and development in young children. FAU - Ltifi, Mohamed Amine AU - Ltifi MA AUID- ORCID: 0000-0003-1784-6961 AD - Higher Institute of Sport and Physical Education of Gafsa, University of Gafsa, Gafsa 2112, Tunisia. AD - Research Laboratory (LR23JS01) "Sport Performance, Health & Society", Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Tunis 2010, Tunisia. FAU - Nejah, Kacem AU - Nejah K AD - LR15JS01 EM2S, Education, Motricity, Sport and Health, Higher Institute of Sport and Physical Education, University of Sfax, Sfax 3029, Tunisia. FAU - Hammami, Fadhel AU - Hammami F AD - Research Laboratory (LR23JS01) "Sport Performance, Health & Society", Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Tunis 2010, Tunisia. FAU - Bica, Monica Delia AU - Bica MD AUID- ORCID: 0000-0002-7767-4762 AD - Faculty of Medical and Behavioral Sciences, "Constantin Brancusi" University of Targu-Jiu, 210185 Targu Jiu, Romania. FAU - Zwierzchowska, Anna AU - Zwierzchowska A AUID- ORCID: 0000-0002-4284-8697 AD - Department of Physical Education and Adapted Physical Activity, The Jerzy Kukuczka Academy of Physical Education in Katowice, 40-959 Katowice, Poland. FAU - Wilk, Michal AU - Wilk M AUID- ORCID: 0000-0001-5799-6337 AD - Institute of Sport Sciences, The Jerzy Kukuczka Academy of Physical Education, 40-065 Katowice, Poland. FAU - Alexe, Dan Iulian AU - Alexe DI AUID- ORCID: 0000-0002-6396-761X AD - Department of Physical and Occupational Therapy, "Vasile Alecsandri" University of Bacau, 600115 Bacau, Romania. FAU - Chelly, Mohamed-Souhaiel AU - Chelly MS AUID- ORCID: 0000-0002-0713-1308 AD - Research Laboratory (LR23JS01) "Sport Performance, Health & Society", Higher Institute of Sport and Physical Education of Ksar Said, University of Manouba, Tunis 2010, Tunisia. LA - eng PT - Journal Article DEP - 20260223 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12939077 OTO - NOTNLM OT - 24-h movement behaviors OT - anthropometric characteristics OT - body mass index (BMI) OT - child development OT - executive functions OT - motor skills OT - preschool children COIS- The authors declare no conflicts of interest. EDAT- 2026/02/27 06:32 MHDA- 2026/02/27 06:33 PMCR- 2026/02/23 CRDT- 2026/02/27 01:02 PHST- 2026/01/18 00:00 [received] PHST- 2026/02/17 00:00 [revised] PHST- 2026/02/20 00:00 [accepted] PHST- 2026/02/27 06:33 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 01:02 [entrez] PHST- 2026/02/23 00:00 [pmc-release] AID - children13020306 [pii] AID - children-13-00306 [pii] AID - 10.3390/children13020306 [doi] PST - epublish SO - Children (Basel). 2026 Feb 23;13(2):306. doi: 10.3390/children13020306. PMID- 41749655 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260227 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 2 DP - 2026 Feb 21 TI - Obesity-Related Changes in Growth Hormone Stimulation Test Performance Under Pediatric Growth Hormone Deficiency. LID - 10.3390/children13020299 [doi] LID - 299 AB - BACKGROUND/OBJECTIVES: The objective of this study is to determine the extent to which obesity alters the diagnostic reliability of the clonidine stimulation test (CST) for growth hormone deficiency (GHD) and whether incorporating insulin-like growth factor 1 (IGF-1) and the annual growth velocity standard deviation score (GV SDS) improves diagnostic precision. METHODS: This retrospective study included 101 children evaluated for short stature using the clonidine stimulation test, with serum GH concentrations determined by a two-site, solid-phase, enzyme-labeled chemiluminescent immunometric assay (Immulite 2000 XPi, Siemens Healthcare Diagnostics, USA). Diagnostic performance was compared between overweight/obese (n = 47) and normal-weight (n = 54) groups. A two-step algorithm was evaluated: Step 1 applied a GH peak threshold of <5 ng/mL; Step 2 integrated IGF-1 SDS < -1.5 and annual GV SDS < -2.0 among children with subthreshold GH responses. RESULTS: The median GH peak was significantly lower in overweight/obese children (4.5 [IQR 2.0-7.4] vs. 8.2 [5.1-11.5] ng/mL; p = 0.043). Although sensitivity remained comparable (82.6% vs. 90.5%; p = 0.666), elevated BMI markedly reduced specificity (50.0% vs. 84.8%; p = 0.008) and overall accuracy (66.0% vs. 87.0%; p = 0.017). Overweight/obese children demonstrated a higher proportion of false-positive CST results than non-obese children (25.5% vs. 9.3%). Among obese children with a GH peak of <5 ng/mL (n = 31), Step 2, which integrates IGF-1 and GV, improved specificity from 50% to 75% and the positive predictive value from 61.3% to 84.2%, correctly reclassifying 9 of 12 children without GHD who would otherwise have been misdiagnosed based on CST alone. CONCLUSIONS: Fixed GH cutoffs may lead to the misclassification of GHD in children with elevated BMI. Obesity significantly reduces the specificity and diagnostic accuracy of CST, increasing false-positive results. A two-step approach integrating IGF-1 and GV improves diagnostic precision and helps to differentiate true GHD from obesity-related GH suppression. FAU - Ozdemir Dilek, Semine AU - Ozdemir Dilek S AUID- ORCID: 0000-0003-2100-0301 AD - Department of Pediatric Endocrinology, University of Health Sciences, Adana City Training and Research Hospital, Adana 01370, Turkey. FAU - Ozguc Comlek, Fatma AU - Ozguc Comlek F AUID- ORCID: 0000-0002-2752-3480 AD - Department of Pediatric Endocrinology, Medical Faculty, Selcuk University, Konya 42250, Turkey. LA - eng PT - Journal Article DEP - 20260221 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12939514 OTO - NOTNLM OT - Growth velocity OT - Insulin-like growth factor 1 OT - clonidine stimulation test OT - growth hormone deficiency OT - obesity OT - overweight COIS- The authors declare no conflicts of interest. EDAT- 2026/02/27 06:31 MHDA- 2026/02/27 06:32 PMCR- 2026/02/21 CRDT- 2026/02/27 01:02 PHST- 2026/01/24 00:00 [received] PHST- 2026/02/16 00:00 [revised] PHST- 2026/02/19 00:00 [accepted] PHST- 2026/02/27 06:32 [medline] PHST- 2026/02/27 06:31 [pubmed] PHST- 2026/02/27 01:02 [entrez] PHST- 2026/02/21 00:00 [pmc-release] AID - children13020299 [pii] AID - children-13-00299 [pii] AID - 10.3390/children13020299 [doi] PST - epublish SO - Children (Basel). 2026 Feb 21;13(2):299. doi: 10.3390/children13020299. PMID- 41749622 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260227 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 2 DP - 2026 Feb 13 TI - Mucous Stools in Infancy as an Early Marker of the Atopic March: A Four-Year Cohort Study of Respiratory Atopy Risk. LID - 10.3390/children13020266 [doi] LID - 266 AB - Background: Mucous stools in infancy are commonly attributed to non-IgE-mediated gastrointestinal food allergies and are generally considered transient and benign. However, whether mucous stools may indicate an atopy-prone clinical phenotype and relate to later respiratory atopy remains insufficiently explored. Objective: To evaluate the long-term risk of respiratory atopy (asthma and/or allergic rhinitis) in infants presenting with mucous stools during the first year of life and to identify early clinical predictors of this risk. Methods: This retrospective cohort study included infants who presented with mucous stools within the first 12 months of life and were followed for four years. Baseline demographic, clinical, dietary, and laboratory data were extracted from standardized medical records. Mucus severity was graded using a pragmatic 0-3 clinical mucus score. The primary outcome was physician-diagnosed asthma and/or allergic rhinitis at four years. Multivariable logistic regression was used to identify independent predictors, with model discrimination assessed by the area under the receiver operating characteristic curve (AUC). Results: A total of 142 infants with complete follow-up data were analyzed. At four years, respiratory atopy was observed in 45 infants (31.7%). In multivariable analysis, family history of atopy (adjusted odds ratio [aOR] 2.68, 95% CI 1.20-5.98, p = 0.016) and wheezing at presentation (aOR 3.74, 95% CI 1.56-8.94, p = 0.003) were independent predictors of respiratory atopy. The mucus score was associated with respiratory atopy in univariable analysis but did not remain an independent predictor in multivariable modeling. The model showed good discrimination (AUC = 0.769). Conclusions: In this cohort of infants presenting with mucous stools in the first year of life, respiratory atopy was observed in nearly one-third by age 4. While mucous stool burden was associated with the outcome in univariable analyses, it did not remain an independent predictor after adjustment. Early wheezing and a family history of atopy were the strongest clinical predictors and may help identify infants who warrant closer follow-up. These findings should be interpreted as associative and hypothesis-generating in the absence of a mucous-stool-free comparison group. FAU - Kaplan, Fatih AU - Kaplan F AUID- ORCID: 0000-0002-2980-5537 AD - Department of Pediatric Allergy and Immunology, Malatya Training and Research Hospital, Malatya 44000, Turkiye. FAU - Gulyuz, Abdulgani AU - Gulyuz A AUID- ORCID: 0000-0001-5797-9115 AD - Department of Pediatrics, Faculty of Medicine, Malatya Turgut Ozal University, Malatya 44210, Turkiye. LA - eng PT - Journal Article DEP - 20260213 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12939429 OTO - NOTNLM OT - allergic rhinitis OT - asthma OT - atopic march OT - early-life immune priming OT - food protein-induced allergic proctocolitis OT - infant wheezing OT - mucous stools OT - non-IgE-mediated food allergy OT - pediatric allergy OT - respiratory atopy COIS- The authors declare no conflicts of interest. EDAT- 2026/02/27 06:32 MHDA- 2026/02/27 06:33 PMCR- 2026/02/13 CRDT- 2026/02/27 01:02 PHST- 2026/01/09 00:00 [received] PHST- 2026/02/03 00:00 [revised] PHST- 2026/02/11 00:00 [accepted] PHST- 2026/02/27 06:33 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 01:02 [entrez] PHST- 2026/02/13 00:00 [pmc-release] AID - children13020266 [pii] AID - children-13-00266 [pii] AID - 10.3390/children13020266 [doi] PST - epublish SO - Children (Basel). 2026 Feb 13;13(2):266. doi: 10.3390/children13020266. PMID- 41749612 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260227 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 2 DP - 2026 Feb 12 TI - Early Childhood Behavioral and Social-Emotional Development Among Asian Indian, Filipino, and Korean Families in the United States: A Pilot Study. LID - 10.3390/children13020256 [doi] LID - 256 AB - BACKGROUND/OBJECTIVES: Socio-cultural adversities and health disparities across Asian American origin groups remain understudied, particularly in early childhood. This limits the development of culturally responsive prevention and intervention strategies. A family-based Asian American epidemiologic study is essential to address these gaps and to inform tailored solutions. As an initial pilot effort, this pilot study was designed primarily to assess feasibility and generate preliminary data to inform future hypothesis-driven, large-scale epidemiologic research. The study objectives were to evaluate the feasibility of a remote study protocol and to collect preliminary data on child development and parental factors among Asian Indian, Filipino, and Korean American families with young children. METHODS: A remote pilot study was conducted in 2024-25 among 48 mother-father-child (age 1-4 years) triads residing in Illinois, including 18 Asian Indian, 12 Filipino, and 18 Korean American mothers. Parents completed an online survey, and children wore an ActiGraph accelerometer on their hips. Analyses were conducted to describe child development, parental experiences, and parenting practices among the three ethnic groups. RESULTS: Of the 48 mothers, 29 (60%) were US-born, and all but 1 had at least a bachelor's degree. All parent pairs completed the survey, whereas only 34 children (71%) provided valid accelerometer data. Disaggregated data showed that, compared to children of Asian Indian mothers, children of Filipino mothers had higher daily screen time (p < 0.10) and higher sleep problem scores (p < 0.05), and children of Korean mothers had higher child-caregiver interaction scores (p < 0.05). Across all three groups, more favorable parenting practices were associated with lower sleep problem scores, higher wellbeing scores, and higher child-caregiver interaction scores (p < 0.01). CONCLUSIONS: The remote study protocol was generally feasible; however, child compliance with hip accelerometer wear was suboptimal. Preliminary data revealed differences in children's physical behaviors and social-emotional development across Asian ethnic groups. A full-scale study should enhance the engagement of socioeconomically diverse families and refine wearable data collection methods to improve data representativeness and completeness. FAU - Kwon, Soyang AU - Kwon S AUID- ORCID: 0000-0002-9359-704X AD - Buehler Center for Health Policy and Economics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. FAU - Gopagani, Nidhi S AU - Gopagani NS AD - Buehler Center for Health Policy and Economics, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. FAU - Bian, Lin AU - Bian L AUID- ORCID: 0000-0001-5438-6736 AD - Department of Psychology, University of Chicago, Chicago, IL 60637, USA. FAU - Vu, Milkie AU - Vu M AD - Department of Preventive Medicine, Northwestern University, Chicago, IL 60611, USA. LA - eng GR - None/Ann & Robert H Lurie Children's Hospital Schreiber Family Center for Early Childhood Health and Wellness/ PT - Journal Article DEP - 20260212 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12939503 OTO - NOTNLM OT - ActiGraph accelerometers OT - Asian Americans OT - acculturation OT - parenting practices OT - physical activity OT - screen time OT - sleep OT - wellbeing COIS- The authors declare no conflicts of interest. EDAT- 2026/02/27 06:32 MHDA- 2026/02/27 06:33 PMCR- 2026/02/12 CRDT- 2026/02/27 01:02 PHST- 2026/01/20 00:00 [received] PHST- 2026/02/09 00:00 [revised] PHST- 2026/02/11 00:00 [accepted] PHST- 2026/02/27 06:33 [medline] PHST- 2026/02/27 06:32 [pubmed] PHST- 2026/02/27 01:02 [entrez] PHST- 2026/02/12 00:00 [pmc-release] AID - children13020256 [pii] AID - children-13-00256 [pii] AID - 10.3390/children13020256 [doi] PST - epublish SO - Children (Basel). 2026 Feb 12;13(2):256. doi: 10.3390/children13020256. PMID- 41749568 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260227 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 2 DP - 2026 Jan 31 TI - Cross-Sectional Assessment of Sleep-Disordered Breathing Prevalence in Pediatric Population with Obesity. LID - 10.3390/children13020212 [doi] LID - 212 AB - BACKGROUND: Childhood obesity is a growing public health concern globally and is associated with a wide spectrum of comorbidities, including sleep-disordered breathing (SDB). SDB remains under-recognized in pediatric population with obesity, particularly in Middle Eastern settings, despite its significant impact on cognitive, behavioral, and metabolic health. OBJECTIVES: To assess the prevalence of SDB among children with obesity aged 6-12 years attending King Faisal University polyclinics in Saudi Arabia and to identify key demographic and anthropometric predictors, with particular emphasis on the mediating role of neck circumference. METHODS: A cross-sectional study was conducted involving 130 children with obesity aged 6-12 years. Data collection included sociodemographic characteristics, anthropometric measurements (BMI percentile, neck and waist circumference), and screening for SDB using the validated Arabic version of the Pediatric Sleep Questionnaire Sleep-Related Breathing Disorder (PSQ-SRBD) scale. Logistic regression and mediation analyses were performed to examine associations and pathways between obesity parameters and SDB risk. RESULTS: Of the 130 participants, 37.7% screened positive for SDB risk. SDB prevalence was higher among males and older children. Neck circumference and BMI percentile were independently associated with SDB risk, with neck circumference mediating the relationship between BMI and SDB. The mediation model indicated that increased BMI contributes to SDB risk both directly and indirectly through increased neck circumference. CONCLUSIONS: SDB is highly prevalent among obese Saudi children, and neck circumference is a significant mediator of risk. Incorporating SDB screening and neck circumference measurements into routine pediatric obesity care can facilitate early detection and management. These findings support the need for integrated, multidisciplinary approaches to improve pediatric health outcomes. FAU - Alarfaj, Abdullah Ahmed AU - Alarfaj AA AD - Department of Surgery, College of Medicine, King Faisal University, Al-Ahsa 31982, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260131 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12939691 OTO - NOTNLM OT - Saudi Arabia OT - childhood obesity OT - neck circumference OT - pediatric OT - sleep-disordered breathing COIS- The author declares no conflicts of interest. EDAT- 2026/02/27 06:31 MHDA- 2026/02/27 06:32 PMCR- 2026/01/31 CRDT- 2026/02/27 01:02 PHST- 2025/12/05 00:00 [received] PHST- 2026/01/23 00:00 [revised] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/02/27 06:32 [medline] PHST- 2026/02/27 06:31 [pubmed] PHST- 2026/02/27 01:02 [entrez] PHST- 2026/01/31 00:00 [pmc-release] AID - children13020212 [pii] AID - children-13-00212 [pii] AID - 10.3390/children13020212 [doi] PST - epublish SO - Children (Basel). 2026 Jan 31;13(2):212. doi: 10.3390/children13020212. PMID- 41749540 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260227 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 2 DP - 2026 Jan 28 TI - Validity and Wear Compliance of Wrist-Worn Consumer Activity Trackers Among Japanese School-Aged Children Under Free-Living Conditions. LID - 10.3390/children13020184 [doi] LID - 184 AB - Background: Wrist-worn consumer activity trackers are widely used to promote physical activity (PA) and reduce sedentary behavior (SB). However, evidence regarding their validity for measuring PA and SB in free-living school-aged children remains limited. This study evaluated the concurrent validity and wear compliance of a wrist-worn consumer activity tracker in school-aged children under free-living conditions with protocol-defined wear requirements. Methods: A total of 102 children (mean age: 10.2 years; 44.1% girls) wore a wrist-worn device (Fitbit Ace) and a waist-worn accelerometer (Omron Active Style Pro HJA-750c, ASP-750c). Of the 1122 person-days collected over 11 days, 135 person-days meeting inclusion criteria for both devices were included (>/=10 h/day wear time and an inter-device wear time difference of /=10 h/day on >/=4 days) was higher for the Fitbit Ace (97.0%) than for the ASP-750c (62.2%). Conclusions: Although the Fitbit Ace may be useful for characterizing general patterns of LPA and SB in school-aged children, caution is warranted for accurate individual-level PA assessment. FAU - Yamakita, Mitsuya AU - Yamakita M AUID- ORCID: 0000-0001-8220-2148 AD - Faculty of Nursing, Yamanashi Prefectural University, 1-6-1 Ikeda, Kofu 400-0062, Japan. AD - Center for Birth Cohort Studies, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, Kofu 400-0016, Japan. FAU - Ando, Daisuke AU - Ando D AUID- ORCID: 0000-0001-7120-9301 AD - Division of Human Sciences, Faculty of Education, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, Kofu 400-0016, Japan. FAU - Sato, Miri AU - Sato M AD - Department of Health and Psychosocial Medicine, School of Medicine, Aichi Medical University, Nagakute 480-1195, Japan. FAU - Akiyama, Yuka AU - Akiyama Y AUID- ORCID: 0000-0003-2739-3185 AD - Center for Birth Cohort Studies, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, Kofu 400-0016, Japan. AD - Faculty of Health and Nutrition, Yamanashi Gakuin University, Kofu 400-8575, Japan. FAU - Yamaguchi, Kaori AU - Yamaguchi K AD - Institute of Health and Sport Sciences, University of Tsukuba, Tsukuba 305-8574, Japan. FAU - Yamagata, Zentaro AU - Yamagata Z AUID- ORCID: 0000-0003-4317-3721 AD - Center for Birth Cohort Studies, Graduate Faculty of Interdisciplinary Research, University of Yamanashi, Kofu 400-0016, Japan. AD - Think Tank for Children and Parents, National Center for Child Health and Development, Tokyo 157-8535, Japan. LA - eng GR - 24K14604, 23H00201, 21K18521, 18H03037, and 17K01794/Japan Society for the Promotion of Science/ GR - Sasakawa Sports Research Grant/Sasakawa Sports Foundation/ GR - Grant for Bone Research/Japan Osteoporosis Foundation/ GR - Health Science Research Grant for Young Researchers/Meiji Yasuda Life Foundation of Health and Welfare/ GR - Grant for Young Researchers/Kitasato University Research Grant/ PT - Journal Article DEP - 20260128 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12939141 OTO - NOTNLM OT - accelerometry OT - acceptability OT - exercise OT - sedentary time OT - wearable electronic devices COIS- The authors declare no conflicts of interest. EDAT- 2026/02/27 06:31 MHDA- 2026/02/27 06:32 PMCR- 2026/01/28 CRDT- 2026/02/27 01:02 PHST- 2025/12/27 00:00 [received] PHST- 2026/01/19 00:00 [revised] PHST- 2026/01/26 00:00 [accepted] PHST- 2026/02/27 06:32 [medline] PHST- 2026/02/27 06:31 [pubmed] PHST- 2026/02/27 01:02 [entrez] PHST- 2026/01/28 00:00 [pmc-release] AID - children13020184 [pii] AID - children-13-00184 [pii] AID - 10.3390/children13020184 [doi] PST - epublish SO - Children (Basel). 2026 Jan 28;13(2):184. doi: 10.3390/children13020184. PMID- 41749519 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260227 LR - 20260813 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 13 IP - 2 DP - 2026 Jan 23 TI - Enhancing Youth Mental Health Through Virtual Lifestyle Behavior Change Support: A Pilot Feasibility Trial. LID - 10.3390/children13020163 [doi] LID - 163 AB - Background: Among many deleterious effects on the well-being of children and youth, the COVID-19 pandemic contributed to a surge in youth mental health distress. This, coupled with pre-existing prolonged wait times for mental health care, highlighted the need for accessible community-based mental health supports. The Healthy Living Project (HELP) is a virtual lifestyle change support program aimed at promoting positive lifestyle changes and improved mental well-being among youth with mental distress. A pilot feasibility study explored youth engagement with HELP e-resources, and preliminary mental health and lifestyle measures over a 3-month period. Methods: Youth were enrolled in a 3-month pilot of the HELP e-resource. Feasibility metrics (recruitment, retention, and platform engagement) were documented, while exploratory self-reported data on emotional and behavioral difficulties, youth quality of life, sedentary behavior (screen time), sleep hygiene, and physical activity were assessed at baseline and 3 months. Results: Twenty-three youth (mean age 15.7 years, SD 1.7) completed baseline assessments and started the intervention, with ten participants retained by the end of the study. Compared with non-completers (n = 13), study completers (n = 10) tended to report higher quality of life and healthier habits (lower screen time, improved sleep hygiene, and higher activity). Ongoing access to HELP over 3 months was associated with suggestive trends toward improvement in emotional and behavioral difficulties and sleep hygiene. Engaged participants who received screen time education tended to report lower screen times as compared to unengaged counterparts. Conclusions: This study provides early insights into the implementation and acceptability of HELP e-resources among youth experiencing mental distress, with suggestive trends toward potential benefit. Low recruitment and high attrition preclude definitive conclusions, and the findings should be interpreted as exploratory. Lessons from this pilot will inform the design of a subsequent trial to more rigorously evaluate feasibility and the potential impact of HELP on youth with mental distress. FAU - Smith, Meaghan Halle AU - Smith MH AUID- ORCID: 0009-0006-3828-571X AD - Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada. FAU - Longmuir, Patricia E AU - Longmuir PE AUID- ORCID: 0000-0003-4827-0870 AD - Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada. AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada. FAU - Robb, Marjorie AU - Robb M AD - Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada. AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada. FAU - Norris, Mark L AU - Norris ML AD - Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada. AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada. FAU - DiGasparro, Miranda AU - DiGasparro M AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada. FAU - Laurie, Kaitlin AU - Laurie K AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada. FAU - Baechler, Natasha AU - Baechler N AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada. FAU - McBrearty, Natasha AU - McBrearty N AD - Crossroads Children's Mental Health Centre, Ottawa, ON K2C 3J2, Canada. FAU - Courtney, Kimberly AU - Courtney K AUID- ORCID: 0009-0006-0384-1704 AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada. FAU - Cooligan, Fiona AU - Cooligan F AD - Children's Hospital of Eastern Ontario, Ottawa, ON K1H 8L1, Canada. FAU - Cloutier, Paula AU - Cloutier P AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada. AD - Children's Hospital of Eastern Ontario, Ottawa, ON K1H 8L1, Canada. FAU - Gray, Clare AU - Gray C AD - Faculty of Medicine, University of Ottawa, Ottawa, ON K1N 6N5, Canada. AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON K1H 8L1, Canada. AD - Children's Hospital of Eastern Ontario, Ottawa, ON K1H 8L1, Canada. LA - eng GR - 2881471275/Frayme Youth Mental Health/ PT - Journal Article DEP - 20260123 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12940004 OTO - NOTNLM OT - adolescents OT - anxiety OT - depression OT - digital intervention OT - health promotion OT - lifestyle change OT - pediatric mental health COIS- The authors declare no conflicts of interest. EDAT- 2026/02/27 06:31 MHDA- 2026/02/27 06:32 PMCR- 2026/01/23 CRDT- 2026/02/27 01:01 PHST- 2025/11/10 00:00 [received] PHST- 2026/01/14 00:00 [revised] PHST- 2026/01/14 00:00 [accepted] PHST- 2026/02/27 06:32 [medline] PHST- 2026/02/27 06:31 [pubmed] PHST- 2026/02/27 01:01 [entrez] PHST- 2026/01/23 00:00 [pmc-release] AID - children13020163 [pii] AID - children-13-00163 [pii] AID - 10.3390/children13020163 [doi] PST - epublish SO - Children (Basel). 2026 Jan 23;13(2):163. doi: 10.3390/children13020163. PMID- 41749487 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260909 IS - 1613-4133 (Electronic) IS - 1613-4125 (Print) IS - 1613-4125 (Linking) VI - 70 IP - 5 DP - 2026 Mar TI - Epigenetic Regulation of the BDNF Gene by Molybdenum in 9 to 11-Year-Old Children: A Targeted Gene DNA Methylation Study. PG - e70426 LID - 10.1002/mnfr.70426 [doi] LID - e70426 AB - While essential trace minerals are known to influence DNA methylation (DNAm), molybdenum's (Mo) role in epigenetic regulation remains largely unexplored. This study examined associations between Mo status and DNAm of the brain-derived neurotrophic factor (BDNF) gene, a critical regulator of neurogenesis, in children aged 9-11 years, focusing on 107 CpG sites across BDNF and its antisense transcript (BDNF-AS).BDNF and BDNF-AS methylation was analyzed in blood samples from 72 children randomly selected from a cohort of 292 participants. Dietary Mo intake was estimated from food records, and creatinine-adjusted urinary Mo levels were quantified. Higher urinary molybdenum was significantly associated with decreased methylation at five BDNF 5'UTR sites (p<.05) and increased methylation of BDNF-AS (p = .0001), consistent with enhanced BDNF transcriptional activity. African American children exhibited lower urinary Mo excretion than European American children, suggesting greater retention, and showed cortisol-associated increases in BDNF methylation not observed in European American children.These findings demonstrate associations between molybdenum status and DNA methylation patterns at the BDNF locus in children. While functional validation through BDNF protein measurement is needed, results suggest molybdenum may influence neurotrophin gene regulation through epigenetic mechanisms, highlighting the importance of trace mineral nutrition during neurodevelopment. CI - (c) 2026 The Author(s). Molecular Nutrition & Food Research published by Wiley-VCH GmbH. FAU - Voss, Margaret A AU - Voss MA AUID- ORCID: 0000-0002-7969-4871 AD - Falk College of Sport and Human Dynamics, Syracuse University Department of Nutrition and Food Studies, Syracuse, New York, USA. FAU - Pilkay, Stefanie R AU - Pilkay SR AUID- ORCID: 0000-0001-5679-2420 AD - School of Social Work, Syracuse University, Syracuse, New York, USA. FAU - Hill, Dustin T AU - Hill DT AUID- ORCID: 0000-0002-4073-6093 AD - Maxwell School of Citizenship and Public Affairs, Syracuse University Public Health Department, Syracuse, New York, USA. FAU - Brann, Lynn S AU - Brann LS AUID- ORCID: 0000-0002-7326-6219 AD - Falk College of Sport and Human Dynamics, Syracuse University Department of Nutrition and Food Studies, Syracuse, New York, USA. FAU - Bendinskas, Kestutis AU - Bendinskas K AUID- ORCID: 0000-0002-0275-520X AD - Department of Chemistry, State University of New York College at Oswego, Oswego, New York, USA. FAU - Parsons, Patrick J AU - Parsons PJ AUID- ORCID: 0000-0001-9133-875X AD - Laboratory of Inorganic and Nuclear Chemistry, Wadsworth Center, New York State Department of Health, Albany, New York, USA. AD - Department of Environmental Health Sciences, College of Integrated Health Sciences, The University at Albany, Albany, New York, USA. FAU - Palmer, Christopher D AU - Palmer CD AUID- ORCID: 0000-0002-6637-991X AD - Laboratory of Inorganic and Nuclear Chemistry, Wadsworth Center, New York State Department of Health, Albany, New York, USA. AD - Department of Environmental Health Sciences, College of Integrated Health Sciences, The University at Albany, Albany, New York, USA. FAU - Gump, Brooks B AU - Gump BB AUID- ORCID: 0000-0001-5906-6651 AD - Maxwell School of Citizenship and Public Affairs, Syracuse University Public Health Department, Syracuse, New York, USA. LA - eng GR - R01 ES023252/ES/NIEHS NIH HHS/United States GR - U2C ES026542/ES/NIEHS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PL - Germany TA - Mol Nutr Food Res JT - Molecular nutrition & food research JID - 101231818 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 81AH48963U (Molybdenum) RN - 7171WSG8A2 (BDNF protein, human) SB - IM MH - Humans MH - *Brain-Derived Neurotrophic Factor/genetics MH - Child MH - *DNA Methylation/drug effects MH - *Epigenesis, Genetic/drug effects MH - *Molybdenum/urine/pharmacology MH - Female MH - Male MH - CpG Islands PMC - PMC12946595 OTO - NOTNLM OT - bdnf OT - epigenetic regulation OT - molybdenum OT - neurodevelopment EDAT- 2026/02/27 06:31 MHDA- 2026/03/06 09:08 PMCR- 2026/02/27 CRDT- 2026/02/27 00:33 PHST- 2025/12/08 00:00 [revised] PHST- 2025/02/28 00:00 [received] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/03/06 09:08 [medline] PHST- 2026/02/27 06:31 [pubmed] PHST- 2026/02/27 00:33 [entrez] PHST- 2026/02/27 00:00 [pmc-release] AID - MNFR70426 [pii] AID - 10.1002/mnfr.70426 [doi] PST - ppublish SO - Mol Nutr Food Res. 2026 Mar;70(5):e70426. doi: 10.1002/mnfr.70426. PMID- 41749303 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Feb 26 TI - Behaviour patterns on social media and their associations with cognitive, social and emotional skills in university students. LID - 10.1186/s40359-026-04109-0 [doi] LID - 622 AB - BACKGROUND: Research on digital behaviour has largely centred on aggregated screen-time metrics, which offer limited insight into how distinct patterns of engagement within social media environments relate to psychosocial competencies. Life skills-encompassing cognitive, social and emotional domains-are fundamental to adaptive functioning in young adults, yet the behavioural features of online interaction that align with these capacities remain insufficiently characterised. METHODS: A cross-sectional study was carried out with 420 university students aged 18-25. Participants completed a questionnaire assessing instrumental, passive and reactive social media behaviours, alongside a validated measure of life skills. Analytical procedures included descriptive statistics, Spearman correlations, exploratory factor analysis and structural equation modelling. Reliability coefficients were estimated from the present sample, and model fit indices were examined to assess structural coherence. RESULTS: Instrumental engagement displayed small positive associations with cognitive and social life skills. Passive browsing and reactive interaction showed small negative associations with emotional and social skills. Although modest in magnitude, these associations displayed a stable configuration across the analytical models, suggesting that behavioural differentiation within social media use aligns with distinct life-skill profiles. CONCLUSIONS: The study contributes to a more nuanced understanding of digital engagement by shifting the analytical focus from global usage frequency to behaviour-specific patterns. Instrumental, goal-directed use aligned with more adaptive skill configurations, whereas passive and reactive tendencies were associated with less favourable profiles. The cross-sectional design and the demographic composition of the sample constrain generalisability, underscoring the need for longitudinal and diverse population studies. The findings reinforce the relevance of intentional and reflective digital practices within university settings, where online interaction is embedded in daily life. FAU - Guerrero-Gutierrez, Nestor AU - Guerrero-Gutierrez N AD - Universidad de Pamplona, Facultad de Salud, Pamplona, 543050, Colombia. FAU - Rojas-Cadena, Silvia Juliana AU - Rojas-Cadena SJ AD - Universidad de Pamplona, Facultad de Salud, Pamplona, 543050, Colombia. FAU - Ibanez-Casadiegos, Eliana AU - Ibanez-Casadiegos E AD - Universidad de Pamplona, Facultad de Salud, Pamplona, 543050, Colombia. FAU - Rozo-Sanchez, Astrid AU - Rozo-Sanchez A AD - Universidad de Pamplona, Facultad de Salud, Pamplona, 543050, Colombia. FAU - Cepeda-Pineda, Daniel AU - Cepeda-Pineda D AD - Universidad de La Sabana, Facultad de Ciencias del Comportamiento, Chia, Cundinamarca, 111321, Colombia. FAU - Carrillo-Sierra, Sandra-Milena AU - Carrillo-Sierra SM AD - Universidad de Pamplona, Facultad de Salud, Pamplona, 543050, Colombia. sandra.carrillo3@unipamplona.edu.co. FAU - Bermudez, Valmore AU - Bermudez V AD - Universidad Simon Bolivar, Centro de Investigaciones en Ciencias de La Vida, Barranquilla, 080001, Colombia. valmore.bermudez@unisimon.edu.co. FAU - Contreras-Velasquez, Julio Cesar AU - Contreras-Velasquez JC AD - Universidad de la Costa, Departamento de Productividad e Innovacion, Barranquilla, Atlantico, 080001, Colombia. FAU - Gomez-Charris, Yulineth AU - Gomez-Charris Y AD - Universidad de la Costa, Departamento de Productividad e Innovacion, Barranquilla, Atlantico, 080001, Colombia. FAU - Rivera-Porras, Diego AU - Rivera-Porras D AD - Universidad de la Costa, Departamento de Productividad e Innovacion, Barranquilla, Atlantico, 080001, Colombia. drivera23@cuc.edu.co. LA - eng PT - Journal Article DEP - 20260226 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - *Students/psychology MH - Male MH - *Social Media/statistics & numerical data MH - Universities MH - Young Adult MH - Adolescent MH - Adult MH - *Social Skills MH - *Emotions MH - *Cognition MH - Media Exposure MH - *Social Behavior MH - Social Interaction MH - Digital Media PMC - PMC13126760 OTO - NOTNLM OT - Digital behaviour OT - Individual differences OT - Life skills OT - Online engagement OT - Social media OT - Young adults COIS- Declarations. Ethics approval and consent to participate: Informed consent was obtained from all participants involved in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/27 00:33 MHDA- 2026/06/27 06:45 PMCR- 2026/02/26 CRDT- 2026/02/26 23:50 PHST- 2025/11/04 00:00 [received] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/06/27 06:45 [medline] PHST- 2026/02/27 00:33 [pubmed] PHST- 2026/02/26 23:50 [entrez] PHST- 2026/02/26 00:00 [pmc-release] AID - 10.1186/s40359-026-04109-0 [pii] AID - 4109 [pii] AID - 10.1186/s40359-026-04109-0 [doi] PST - epublish SO - BMC Psychol. 2026 Feb 26;14(1):622. doi: 10.1186/s40359-026-04109-0. PMID- 41749054 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 1532-6535 (Electronic) IS - 0009-9236 (Print) IS - 0009-9236 (Linking) VI - 119 IP - 6 DP - 2026 Jun TI - Population Pharmacokinetics of Dupilumab in Adults, Adolescents, and Children With Eosinophilic Esophagitis. PG - 1555-1564 LID - 10.1002/cpt.70233 [doi] AB - Dupilumab, a fully human monoclonal antibody that blocks key drivers of type 2 inflammation, is approved across 8 diseases, including eosinophilic esophagitis. Subcutaneous dupilumab 300 mg weekly improved outcomes vs. placebo in adults (aged >/= 18 years) and adolescents (aged >/= 12 to < 18 years) during the phase III LIBERTY EoE TREET study (NCT03633617). The phase III EoE KIDS study (NCT04394351) demonstrated efficacy of a weight-tiered, higher exposure dupilumab dose approximating 300 mg weekly exposure in TREET vs. placebo in children aged >/= 1 to < 12 years. To characterize dupilumab pharmacokinetics, inform clinical trial design, and optimize posology, a population pharmacokinetic model was developed using dupilumab concentration data from 6 single-dose studies in healthy adults and 3 eosinophilic esophagitis clinical trials. Healthy volunteer data were used to construct a stable base model; incorporation of patient data allowed estimation covariate effects for the disease population. Observational data from up to 52 weeks of treatment in eosinophilic esophagitis trials validated model performance. Significant effects were identified for body weight on clearance and volume of distribution, including time-varying weight in children and adolescents, and of albumin on clearance; age was not a significant covariate. Simulations identified alternative dupilumab regimens for patients weighing >/= 5 to <15 kg (200 mg every 3 weeks) and >/= 40 to <60 kg (300 mg weekly) with improved exposure matching to the 300 mg weekly dose in TREET. The final model was used to inform regulatory approval and potential future clinical trial design. CI - (c) 2026 The Author(s). Clinical Pharmacology & Therapeutics published by Wiley Periodicals LLC on behalf of American Society for Clinical Pharmacology and Therapeutics. FAU - Nguyen, Jenny-Hoa AU - Nguyen JH AD - Regeneron Pharmaceuticals Inc., Tarrytown, New York, USA. FAU - Chehade, Mirna AU - Chehade M AUID- ORCID: 0000-0002-7177-2791 AD - Mount Sinai Center for Eosinophilic Disorders, Icahn School of Medicine at Mount Sinai, New York, New York, USA. FAU - Dellon, Evan S AU - Dellon ES AUID- ORCID: 0000-0003-1167-1101 AD - University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA. FAU - Radin, Allen AU - Radin A AUID- ORCID: 0009-0003-0736-8115 AD - Regeneron Pharmaceuticals Inc., Tarrytown, New York, USA. FAU - Chittenden, Jason AU - Chittenden J AD - Regeneron Pharmaceuticals Inc., Tarrytown, New York, USA. FAU - Kamal, Mohamed A AU - Kamal MA AD - Regeneron Pharmaceuticals Inc., Tarrytown, New York, USA. FAU - Louisias, Margee AU - Louisias M AD - Sanofi, Cambridge, Massachusetts, USA. FAU - Xu, Christine AU - Xu C AD - Sanofi, Morristown, New Jersey, USA. FAU - Kosloski, Matthew P AU - Kosloski MP AUID- ORCID: 0000-0002-6642-2439 AD - Regeneron Pharmaceuticals Inc., Tarrytown, New York, USA. LA - eng SI - ClinicalTrials.gov/NCT03633617 SI - ClinicalTrials.gov/NCT04394351 PT - Clinical Trial, Phase III PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260226 PL - United States TA - Clin Pharmacol Ther JT - Clinical pharmacology and therapeutics JID - 0372741 RN - 0 (Antibodies, Monoclonal, Humanized) RN - 420K487FSG (dupilumab) SB - IM MH - Humans MH - *Eosinophilic Esophagitis/drug therapy MH - Adolescent MH - *Antibodies, Monoclonal, Humanized/pharmacokinetics/administration & dosage MH - Child MH - Female MH - Male MH - Adult MH - *Models, Biological MH - Child, Preschool MH - Young Adult MH - Age Factors MH - Body Weight MH - Injections, Subcutaneous PMC - PMC13156347 COIS- M.C. has received consultancy fees from Adare Pharma Solutions/Ellodi, Allakos, AstraZeneca, Apogee Therapeutics, Bristol Myers Squibb, Nexstone Immunology/Uniquity Bio, Phathom, Recludix Pharma, Regeneron Pharmaceuticals Inc., Sanofi, and Shire/Takeda. M.C. has also received research funding from Adare Pharma Solutions/Ellodi, Allakos, AstraZeneca, Celgene, Danone, Regeneron Pharmaceuticals Inc., and Shire/Takeda. E.S.D has received consultancy fees from AbbVie, Adare/Ellodi, Akesobio, Alfasigma, ALK, Allakos, Amgen, Apollo, Aqilion, Arena/Pfizer, Aslan, AstraZeneca, Avir, Biocryst, Bryn, Calypso, Celgene/Receptos/BMS, Celldex, EsoCap, Eupraxia, Dr. Falk Pharma, Ferring, GI Reviewers, GSK, Holoclara, Invea, Knightpoint, LucidDx, Morphic, Nexstone Immunology/Uniquity, Nutricia, Parexel/Calyx, Phathom, Regeneron Pharmaceuticals Inc., Revolo, Robarts/Alimentiv, Sanofi, Shire/Takeda, Target RWE, and Upstream Bio. E.S.D. has also received research funding from Adare/Ellodi, Allakos, Arena/Pfizer, AstraZeneca, Celgene/Receptos/BMS, Celldex, Eupraxia, Ferring, GSK, Meritage, Miraca, Nutricia, Regeneron Pharmaceuticals Inc., Revolo, Sanofi, and Shire/Takeda. E.S.D. has additionally received educational grants from Allakos, Aqilion, Holoclara, and Invea. A.R., J.C., M.A.K., and M.P.K. are employees and shareholders at Regeneron Pharmaceuticals Inc. J.-H.N. is a current employee of Johnson & Johnson and former employee and shareholder at Regeneron Pharmaceuticals Inc. M.L. and C.X. are employees and may hold stock and/or stock options at Sanofi. EDAT- 2026/02/27 00:33 MHDA- 2026/05/09 00:34 PMCR- 2026/02/26 CRDT- 2026/02/26 23:30 PHST- 2025/06/23 00:00 [received] PHST- 2026/01/28 00:00 [accepted] PHST- 2026/05/09 00:34 [medline] PHST- 2026/02/27 00:33 [pubmed] PHST- 2026/02/26 23:30 [entrez] PHST- 2026/02/26 00:00 [pmc-release] AID - CPT70233 [pii] AID - 10.1002/cpt.70233 [doi] PST - ppublish SO - Clin Pharmacol Ther. 2026 Jun;119(6):1555-1564. doi: 10.1002/cpt.70233. Epub 2026 Feb 26. PMID- 41748748 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261017 IS - 1530-0447 (Electronic) IS - 0031-3998 (Print) IS - 0031-3998 (Linking) VI - 100 IP - 3 DP - 2026 Aug TI - Neonatal steroid exposure and body composition in preterm infants at discharge. PG - 1215-1222 LID - 10.1038/s41390-026-04796-w [doi] AB - BACKGROUND: Corticosteroids are frequently used in very preterm (VPT) infants. Corticosteroids can increase adiposity and decrease lean mass, with unclear effects in VPT infants. We hypothesized that corticosteroid exposure in VPT infants would be associated with increased fat mass (FM), %FM, and decreased fat-free mass (FFM). METHODS: This prospective study included 62 infants <32 weeks' gestational age (GA) or <1500 grams birth weight (BW). Body composition was obtained using bioelectrical impedance analysis (BIA) at neonatal intensive care unit (NICU) discharge. We estimated FFM from BIA, calculated FM and %FM, and determined z-scores for postmenstrual age and sex. Body composition indices in steroid-exposed and non-steroid-exposed subjects were compared using Mann-Whitney U tests. RESULTS: The mean GA was 28 +/- 2.5 weeks, and the mean BW was 1089+/-401grams. Fourteen infants (22.5%) had steroid exposure, which was associated with significantly higher FM, %FM, and FFM. However, no significant differences in FM, %FM, and FFM z-scores were observed. CONCLUSION: Steroid exposure was associated with differences in the body composition of VPT infants at NICU discharge. However, after adjusting for post-menstrual age and sex using z-scores, the difference was no longer significant, likely reflecting the longer hospitalization and later postmenstrual age at discharge in the steroid-exposed cohort. IMPACT: Corticosteroids are regularly utilized in neonatal intensive care units, and the impact of these medications on body composition in preterm neonates is unclear. Our study found no significant difference in fat mass (FM), %FM, or fat-free mass (FFM) z-scores between very preterm (VPT) infants with and without steroid exposure. Our study highlights the feasibility of using bioelectrical impedance analysis (BIA) to assess body composition in the NICU. CI - (c) 2026. The Author(s). FAU - Kraemer, Megan K AU - Kraemer MK AD - Pediatrics, Rush University Medical Center, Chicago, IL, USA. megan_kraemer@rush.edu. FAU - Johnson, Tricia J AU - Johnson TJ AD - Health Systems Management-CHS, Rush University Medical Center, Chicago, IL, USA. FAU - Bell, Katherine A AU - Bell KA AD - Pediatrics, Brigham and Women's Hospital, Boston, MA, USA. FAU - Mulcahy, Delaney C AU - Mulcahy DC AD - Pediatrics, Rush University Medical Center, Chicago, IL, USA. FAU - Cerwinske, Leah A AU - Cerwinske LA AD - Food and Nutrition Services, Rush University Medical Center, Chicago, IL, USA. FAU - Patra, Kousiki AU - Patra K AD - Pediatrics, Rush University Medical Center, Chicago, IL, USA. FAU - Appelhans, Bradley M AU - Appelhans BM AD - Family and Preventive Medicine, Rush University Medical Center, Chicago, IL, USA. FAU - David, Jieun AU - David J AD - Pediatrics, Rush University Medical Center, Chicago, IL, USA. FAU - Belfort, Mandy Brown AU - Belfort MB AD - Pediatrics, Brigham and Women's Hospital, Boston, MA, USA. FAU - Diep, Quyen M AU - Diep QM AD - Biostatistics Core, Rush University Medical Center, Chicago, IL, USA. FAU - Patel, Aloka L AU - Patel AL AD - Pediatrics, Rush University Medical Center, Chicago, IL, USA. LA - eng GR - R01 HD107348/HD/NICHD NIH HHS/United States GR - R01 MD013969/MD/NIMHD NIH HHS/United States PT - Journal Article DEP - 20260227 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 RN - 0 (Adrenal Cortex Hormones) SB - IM EIN - Pediatr Res. 2026 Jul;100(2):953. doi: 10.1038/s41390-026-05062-9. PMID: 42082736 MH - Humans MH - Infant, Newborn MH - *Body Composition/drug effects MH - Female MH - Male MH - Prospective Studies MH - *Infant, Premature MH - *Adrenal Cortex Hormones/adverse effects/therapeutic use MH - Electric Impedance MH - Gestational Age MH - Intensive Care Units, Neonatal MH - Patient Discharge PMC - PMC13140789 MID - NIHMS2165141 COIS- Competing interests: Dr. Patel serves as a consultant for Medela LLC. Dr. Johnson serves as a consultant for Medela AG. The other authors declare no potential conflicts of interest. Consent statement: Written informed consent was obtained from parent/guardian at time of enrollment for all subjects. EDAT- 2026/02/27 00:33 MHDA- 2026/10/16 05:32 PMCR- 2026/05/06 CRDT- 2026/02/26 23:21 PHST- 2025/08/08 00:00 [received] PHST- 2025/12/27 00:00 [accepted] PHST- 2025/12/12 00:00 [revised] PHST- 2026/10/16 05:32 [medline] PHST- 2026/02/27 00:33 [pubmed] PHST- 2026/02/26 23:21 [entrez] PHST- 2026/05/06 00:00 [pmc-release] AID - 10.1038/s41390-026-04796-w [pii] AID - 10.1038/s41390-026-04796-w [doi] PST - ppublish SO - Pediatr Res. 2026 Aug;100(3):1215-1222. doi: 10.1038/s41390-026-04796-w. Epub 2026 Feb 27. PMID- 41748531 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Feb 27 TI - Food brand recall and its association with diet-related behaviours among Thai children. PG - e63 LID - 10.1017/S1368980026102183 [doi] LID - e63 AB - OBJECTIVE: Food brand marketing is one of the techniques used by the food industry to create positive images and enhance brand recall among children. The objectives of this study were to assess food and beverage brand recall and to examine the sociodemographic characteristics associated with food brand recall, as well as the purchasing and consumption of branded foods among Thai children. DESIGN: Cross-sectional analysis of secondary data from the 2024 Monitoring on Food and Beverage Marketing to Children in Thailand survey. A validated and reliable questionnaire was used for data collection. Descriptive statistics were used to summarise sociodemographic characteristics, food and beverage brand recall, and purchasing behaviours. Associations between brand recall and purchasing behaviours were examined using multivariable logistic regression models. SETTING: Eleven provinces across Thailand. PARTICIPANTS: A total of 2113 children aged 10-18 years. RESULTS: Nearly 40 % of children recalled sweetened beverage brands, while 35 % recalled snack brands. Food and beverage brand recall was statistically associated with purchasing and consumption of branded foods across several product categories after adjustment for sociodemographic characteristics. CONCLUSIONS: Food and beverage brand recall was commonly reported among Thai children and showed statistically significant associations with purchasing and consumption behaviours. These findings contribute to the evidence base on food marketing exposure among children in Thailand. FAU - Jindarattanaporn, Nongnuch AU - Jindarattanaporn N AUID- ORCID: 0000-0002-6241-7851 AD - Institute for Population and Social Research, https://ror.org/01znkr924Mahidol University, Thailand. FAU - Chuenchom, Salakjit AU - Chuenchom S AD - Institute for Population and Social Research, https://ror.org/01znkr924Mahidol University, Thailand. LA - eng PT - Journal Article DEP - 20260227 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Child MH - Thailand MH - Cross-Sectional Studies MH - Female MH - Male MH - Adolescent MH - *Mental Recall MH - *Diet/psychology/statistics & numerical data MH - *Marketing MH - *Feeding Behavior/psychology MH - Beverages MH - Surveys and Questionnaires MH - Snacks MH - *Food MH - Food Preferences/psychology PMC - PMC13087976 OTO - NOTNLM OT - Brand recall OT - Children OT - Consumption OT - Food OT - Purchasing COIS- The authors report there are no competing interests to declare. The authors report there are no competing interests to declare. EDAT- 2026/02/27 00:33 MHDA- 2026/03/31 06:59 PMCR- 2026/02/27 CRDT- 2026/02/26 23:12 PHST- 2026/03/31 06:59 [medline] PHST- 2026/02/27 00:33 [pubmed] PHST- 2026/02/26 23:12 [entrez] PHST- 2026/02/27 00:00 [pmc-release] AID - S1368980026102183 [pii] AID - 10.1017/S1368980026102183 [doi] PST - epublish SO - Public Health Nutr. 2026 Feb 27;29(1):e63. doi: 10.1017/S1368980026102183. PMID- 41748492 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260709 IS - 1939-3229 (Electronic) IS - 1939-3210 (Linking) VI - 19 IP - 2 DP - 2026 Jun TI - PCBs in honey, milk, and eggs from Algiers (Algeria) and its health risks. PG - 149-157 LID - 10.1080/19393210.2026.2629439 [doi] AB - Polychlorinated biphenyls (PCBs) are persistent organic pollutants that bioaccumulate in the food chain and may be a threat for human health. This study quantified PCB 118, PCB 138, PCB 153, and PCB 180 in cow's milk, poultry eggs, and honey from Algiers and evaluated dietary exposure for adults and infants. A total of 180 samples (20 per matrix and site) were analysed by a validated GC-MS method. PCB levels ranged from < LOD to 13.6 ng/g in milk, < LOD to 10.6 ng/g in honey and < LOD to 35.3 ng/g in eggs, with significant regional differences (p < 0.05) and generally higher levels in Beraki. Estimated daily intakes were consistently higher in infants than adults. Nevertheless, congener specific hazard quotients/toxic equivalents and cumulative hazard indices remained below 1 for all matrices, indicating low non carcinogenic risk under the applied assumptions. These baseline data support monitoring and source oriented mitigation strategies in Algeria for food safety reasons. FAU - Chebli, Akli Islem AU - Chebli AI AUID- ORCID: 0000-0001-9242-9733 AD - Department of Pharmacy, Faculty of Pharmacy, University of Medical Sciences, Algiers, Algeria. AD - Research and Development Department, National Center of Toxicology, Algiers, Algeria. FAU - Iko Afe, O Herbert AU - Iko Afe OH AD - Department of Nutrition, Food Sciences and Technology, Faculty of Agronomic Sciences, University of Abomey-Calavi, Cotonou, Benin. FAU - Gbetokpanou, Christin Sogbossi AU - Gbetokpanou CS AD - Department of Nutrition, Food Sciences and Technology, Faculty of Agronomic Sciences, University of Abomey-Calavi, Cotonou, Benin. FAU - Uc-Peraza, Russell Giovanni AU - Uc-Peraza RG AUID- ORCID: 0000-0003-4014-3172 AD - Division de Ciencias, ingenieria Y Tecnologia, Universidad Autonoma Del Estado de Quintana Roo (UAEQROO), Chetumal, Mexico. FAU - Mehouel, Fetta AU - Mehouel F AUID- ORCID: 0000-0001-9771-2183 AD - Institute of Veterinary Sciences, University of Constantine 1, Constantine, Algeria. AD - Laboratory of Research Food Hygiene and Quality Insurance System (HASAQ), Higher National Veterinary School of Algiers (ENSV- Alger), Algiers, Algeria. FAU - Amziane, Ahmed AU - Amziane A AD - Department of Pharmacy, Faculty of Pharmacy, University of Medical Sciences, Algiers, Algeria. AD - Research and Development Department, National Center of Toxicology, Algiers, Algeria. FAU - Fassinou, Grace L Setondji AU - Fassinou GLS AD - Department of Nutrition, Food Sciences and Technology, Faculty of Agronomic Sciences, University of Abomey-Calavi, Cotonou, Benin. FAU - Djouzi, Nihel AU - Djouzi N AD - Department of Natural and Life Sciences, Faculty of Sciences, University of Algiers 1, Algiers, Algeria. FAU - Kihal, Dounia AU - Kihal D AD - Department of Natural and Life Sciences, Faculty of Sciences, University of Algiers 1, Algiers, Algeria. FAU - Abdennour, Sara AU - Abdennour S AD - Department of Pharmacy, Faculty of Medicine, University of Setif 1, Setif, Algeria. FAU - Zebbiche, Younes AU - Zebbiche Y AUID- ORCID: 0000-0002-1427-8025 AD - Department of Pharmacy, Faculty of Pharmacy, University of Medical Sciences, Algiers, Algeria. LA - eng PT - Journal Article DEP - 20260226 PL - England TA - Food Addit Contam Part B Surveill JT - Food additives & contaminants. Part B, Surveillance JID - 101317183 RN - DFC2HB4I0K (Polychlorinated Biphenyls) RN - 0 (Environmental Pollutants) SB - IM MH - Animals MH - Humans MH - *Food Contamination/analysis MH - *Polychlorinated Biphenyls/analysis/toxicity MH - *Eggs/analysis MH - *Milk/chemistry MH - Algeria MH - *Honey/analysis MH - Risk Assessment MH - Infant MH - Adult MH - Gas Chromatography-Mass Spectrometry MH - Dietary Exposure MH - *Environmental Pollutants/analysis MH - Cattle MH - Female OTO - NOTNLM OT - Algeria OT - PCBs OT - Pops OT - food safety OT - risk assessment EDAT- 2026/02/27 00:34 MHDA- 2026/05/13 12:31 CRDT- 2026/02/26 22:52 PHST- 2026/05/13 12:31 [medline] PHST- 2026/02/27 00:34 [pubmed] PHST- 2026/02/26 22:52 [entrez] AID - 10.1080/19393210.2026.2629439 [doi] PST - ppublish SO - Food Addit Contam Part B Surveill. 2026 Jun;19(2):149-157. doi: 10.1080/19393210.2026.2629439. Epub 2026 Feb 26. PMID- 41747359 OWN - NLM STAT- MEDLINE DCOM- 20260820 LR - 20260820 IS - 1879-680X (Electronic) IS - 1761-7727 (Linking) VI - 24 IP - 3 DP - 2026 Sep TI - Feasibility of predicting vertical cephalometric angles from panoramic radiographs using deep learning. PG - 101156 LID - S1761-7227(26)00017-3 [pii] LID - 10.1016/j.ortho.2026.101156 [doi] AB - INTRODUCTION: Early identification of vertical skeletal discrepancies is essential for orthodontic diagnosis and treatment planning. Since panoramic radiographs (OPGs) are more routinely obtained than lateral cephalometric radiographs (LCR), this study evaluated whether artificial intelligence could predict vertical skeletal angles on OPGs. METHODS: LCRs and OPGs of 715 patients were retrospectively collected from four imaging centre (2022-2025). LCRs were traced using WebCeph to obtain reference measurements of the Frankfort-mandibular plane angle (FMA), gonial angle, and Sum of Bjork. Multiple convolutional neural network (CNN) architectures (EfficientNet-B3, DenseNet121/169, ResNet-50/101, VGG16/19) were trained to predict these parameters from corresponding OPGs. Ensemble averaging was also employed as a non-learned aggregation strategy. Model performance was evaluated using mean absolute error (MAE) and the coefficient of determination (R(2)). Wilcoxon signed-rank test assessed the differences in predictive performance. Inter-model agreement was quantified using intraclass correlation coefficients (ICC). Gradient-weighted Class Activation Mapping (Grad-CAM) was used for model interpretability. RESULTS: Ensemble averaging achieved the highest predictive accuracy across all angular parameters, with MAE values of 2.53 degrees +/-0.08 for FMA, 3.16 degrees +/-0.10 for the gonial angle, and 3.04 degrees +/-0.09 for the Sum of Bjork. High agreement was observed among the CNN architectures for all measurements (P<0.001). Grad-CAM visualizations indicated that predictions primarily relied on the gonial angle region, followed by the condylar area and mandibular ramus. CONCLUSION: Deep learning demonstrates promising potential for estimating vertical angular measurements on OPGs. Although current prediction errors preclude replacement of cephalometric analysis, the incorporation of larger datasets, geometry-aware models, and external validation will help improving predictive accuracy. CI - Copyright (c) 2026 CEO. Published by Elsevier Masson SAS. All rights reserved. FAU - Ashkan, Ali AU - Ashkan A AD - Department of Orthodontics, School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran. FAU - Behnaz, Mohammad AU - Behnaz M AD - Department of Orthodontics, School of dentistry, Shahid Beheshti University of medical sciences, Tehran, Iran. FAU - Taramsari, Ali Rahbar AU - Taramsari AR AD - School of Health and Medical Sciences, City St George's, University of London, London, United Kingdom. FAU - Morvaridi Farimani, Reza AU - Morvaridi Farimani R AD - Department of Rehabilitative and Reconstructive Dentistry, University of Louisville, Louisville, KY, United States of America. FAU - Radmard, Bahareh AU - Radmard B AD - School of Health and Medical Sciences, City St George's, University of London, London, United Kingdom. FAU - Farhadian, Maryam AU - Farhadian M AD - Department of Biostatistics, School of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran. FAU - Motie, Parisa AU - Motie P AD - Medical Image and Signal Processing Research Center, Medical University of Isfahan, Isfahan, Iran. Electronic address: Pm.motie@gmail.com. LA - eng PT - Journal Article DEP - 20260226 PL - France TA - Int Orthod JT - International orthodontics JID - 101184882 SB - IM MH - Humans MH - *Cephalometry/methods MH - *Radiography, Panoramic/methods MH - *Deep Learning MH - Retrospective Studies MH - Convolutional Neural Networks MH - Feasibility Studies MH - Female MH - Mandible/diagnostic imaging MH - Male MH - Adolescent OTO - NOTNLM OT - Artificial intelligence OT - Deep learning OT - Frankfort-mandibular plane angle OT - Gonial angle OT - Panoramic radiography OT - Sum of Bjork OT - Vertical skeletal pattern COIS- Disclosure of interest the authors declare that they have no competing interest. EDAT- 2026/02/27 00:33 MHDA- 2026/08/20 23:35 CRDT- 2026/02/26 18:02 PHST- 2025/11/21 00:00 [received] PHST- 2026/02/05 00:00 [revised] PHST- 2026/02/06 00:00 [accepted] PHST- 2026/08/20 23:35 [medline] PHST- 2026/02/27 00:33 [pubmed] PHST- 2026/02/26 18:02 [entrez] AID - S1761-7227(26)00017-3 [pii] AID - 10.1016/j.ortho.2026.101156 [doi] PST - ppublish SO - Int Orthod. 2026 Sep;24(3):101156. doi: 10.1016/j.ortho.2026.101156. Epub 2026 Feb 26. PMID- 41747357 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260709 IS - 1476-5616 (Electronic) IS - 0033-3506 (Linking) VI - 253 DP - 2026 Apr TI - The relationship between intimate partner violence and body mass index based on a Chinese national survey. PG - 106093 LID - S0033-3506(25)00539-6 [pii] LID - 10.1016/j.puhe.2025.106093 [doi] AB - OBJECTIVES: The objective of this study was to explore the association between intimate partner violence (IPV) and body mass index (BMI), and to further investigate how the severity and specific subtypes of IPV are associated with BMI outcomes. STUDY DESIGN: A national, cross-sectional survey was conducted. METHODS: Data from 23,469 adults in the 2023 Psychology and Behavior Investigation of Chinese Residents were analyzed to examine associations between IPV and BMI. IPV severity and subtypes were assessed via a validated five-item scale, and BMI was categorized according to Chinese standards. Multinomial logistic regression and restricted cubic spline models evaluated both linear and nonlinear relationships, with subgroup analyses exploring variations by sociodemographic and psychosocial factors. RESULTS: Among 23,469 participants, IPV exposure showed a significant inverted U-shaped relationship with BMI, peaking at a score of 7.41; mild to moderate IPV exposure was associated with a higher risk of overweight/obesity, while severe IPV was associated with underweight. Subtype analyses revealed that sexual violence and controlling behaviours were correlated with underweight, whereas emotional and verbal abuse were associated with overweight and obesity. CONCLUSIONS: The study demonstrated that the severity and subtype of intimate partner violence (IPV) exposure have distinct effects on body mass index (BMI) outcomes, underscoring the need for integrating IPV screening into weight-related assessments and for developing targeted, context-specific public health interventions. CI - Copyright (c) 2026 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved. FAU - Wang, Ling AU - Wang L AD - School of Nursing, Fudan University, Shanghai, China. FAU - Xiao, Runxi AU - Xiao R AD - School of Nursing, Fudan University, Shanghai, China. FAU - Wu, Yibo AU - Wu Y AD - Department of Nursing, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Hangzhou, China. FAU - Cao, Jiacheng AU - Cao J AD - School of Nursing, Fudan University, Shanghai, China. FAU - Weng, Yajuan AU - Weng Y AD - School of Nursing, Fudan University, Shanghai, China. FAU - Qian, Huijuan AU - Qian H AD - Nursing Department, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhang, Qi AU - Zhang Q AD - School of Nursing, Fudan University, Shanghai, China. FAU - Yun, Bei AU - Yun B AD - School of Nursing, Fudan University, Shanghai, China. FAU - Cai, Tingting AU - Cai T AD - School of Nursing, Fudan University, Shanghai, China. FAU - Wu, Fulei AU - Wu F AD - School of Nursing, Fudan University, Shanghai, China. Electronic address: wufulei@fudan.edu.cn. FAU - Yuan, Changrong AU - Yuan C AD - School of Nursing, Fudan University, Shanghai, China. Electronic address: yuancr@fudan.edu.cn. LA - eng PT - Journal Article DEP - 20260225 PL - Netherlands TA - Public Health JT - Public health JID - 0376507 SB - IM MH - Humans MH - Female MH - *Body Mass Index MH - *Intimate Partner Violence/statistics & numerical data MH - Cross-Sectional Studies MH - China/epidemiology MH - Adult MH - Male MH - Middle Aged MH - Surveys and Questionnaires MH - Risk Factors MH - Obesity/epidemiology MH - Young Adult MH - Overweight/epidemiology MH - Adolescent OTO - NOTNLM OT - Association OT - Body mass index OT - Cross-sectional study OT - Intimate partner violence COIS- Declaration of competing interests The authors declare no competing interests. EDAT- 2026/02/27 00:33 MHDA- 2026/03/20 00:59 CRDT- 2026/02/26 18:02 PHST- 2025/07/01 00:00 [received] PHST- 2025/11/29 00:00 [revised] PHST- 2025/12/03 00:00 [accepted] PHST- 2026/03/20 00:59 [medline] PHST- 2026/02/27 00:33 [pubmed] PHST- 2026/02/26 18:02 [entrez] AID - S0033-3506(25)00539-6 [pii] AID - 10.1016/j.puhe.2025.106093 [doi] PST - ppublish SO - Public Health. 2026 Apr;253:106093. doi: 10.1016/j.puhe.2025.106093. Epub 2026 Feb 25. PMID- 41747238 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260226 LR - 20260813 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 9 DP - 2026 Feb 26 TI - Using Wearable Video Cameras to Assess Screen Use Contexts in Preschool-Aged Children: Pilot Observational Study. PG - e85215 LID - 10.2196/85215 [doi] LID - e85215 AB - BACKGROUND: Wearable video cameras may offer a feasible approach to assess the contexts of screen use (eg, screen content and co-use) among preschool-aged children. OBJECTIVE: The objective of this study was to assess the contexts of screen use among preschool-aged children using wearable video cameras. METHODS: Children aged 2 to 5 years from Melbourne, Australia, wore a video camera for 1 day in the home environment during May 2023. One researcher manually coded video footage second by second; 15% was double coded for reliability. Coding included device type, screen activity, screen content classified using Common Sense Media ratings, streaming service, setting, social interaction, screen multitasking, and concurrent behaviors. RESULTS: A total of 37,944 seconds (10.5 hours) of video camera footage from 8 children were identified and coded as screen use, equating to 21.8% (37,944/174,290) of total camera wear time (range 0.3%-74.0%). Screen use was predominately characterized by program viewing (n=37,461, 98.7% seconds) on televisions (n=34,192, 90.1% seconds) in the lounge room (n=33,710, 88.8% seconds). Programs scored low for educational value (mean 1.7, SD 1.4 of 5 stars), and approximately one-third (3/9, 33.3%) of programs were classified as appropriate for an age older than that of the children in this sample. Screen multitasking was rare (n=46, 0.1% of seconds), and coviewing occurred in approximately one-third of all screen use (n=11,010, 29%). CONCLUSIONS: Contexts considered beneficial for development (eg, educational and age-appropriate content) were infrequently observed. This suggests that interventions to equip parents with practical strategies to identify genuine educational content and recognize and avoid age-inappropriate content are warranted. However, our small sample size limits generalizability. CI - (c) Amanda Machell, Katherine Downing, Simone J J M Verswijveren, Kylie D Hesketh. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org). FAU - Machell, Amanda AU - Machell A AUID- ORCID: 0000-0002-9058-3435 AD - Institute for Physical Activity and Nutrition (IPAN), Deakin University, 1 Gheringhap Street, Geelong, 3220, Australia, 61 392446613. FAU - Downing, Katherine AU - Downing K AUID- ORCID: 0000-0002-6552-8506 AD - Institute for Physical Activity and Nutrition (IPAN), Deakin University, 1 Gheringhap Street, Geelong, 3220, Australia, 61 392446613. FAU - Verswijveren, Simone J J M AU - Verswijveren SJJM AUID- ORCID: 0000-0002-7709-7416 AD - Institute for Physical Activity and Nutrition (IPAN), Deakin University, 1 Gheringhap Street, Geelong, 3220, Australia, 61 392446613. FAU - Hesketh, Kylie D AU - Hesketh KD AUID- ORCID: 0000-0002-2702-7110 AD - Institute for Physical Activity and Nutrition (IPAN), Deakin University, 1 Gheringhap Street, Geelong, 3220, Australia, 61 392446613. LA - eng PT - Journal Article DEP - 20260226 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC12945350 OTO - NOTNLM OT - early childhood OT - screen time OT - smartphone OT - tablet OT - television COIS- Conflicts of Interest: None declared. EDAT- 2026/02/26 19:29 MHDA- 2026/02/26 19:30 PMCR- 2026/02/26 CRDT- 2026/02/26 16:45 PHST- 2025/10/03 00:00 [received] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/02/26 19:30 [medline] PHST- 2026/02/26 19:29 [pubmed] PHST- 2026/02/26 16:45 [entrez] PHST- 2026/02/26 00:00 [pmc-release] AID - v9i1e85215 [pii] AID - 85215 [pii] AID - 10.2196/85215 [doi] PST - epublish SO - JMIR Pediatr Parent. 2026 Feb 26;9:e85215. doi: 10.2196/85215. PMID- 41746798 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260922 IS - 1465-735X (Electronic) IS - 0146-8693 (Print) IS - 0146-8693 (Linking) VI - 51 IP - 6 DP - 2026 Jun 1 TI - Retention, blinding, and health outcomes from a rural pediatric obesity feasibility randomized control trial. PG - 472-482 LID - 10.1093/jpepsy/jsag016 [doi] AB - OBJECTIVE: To evaluate the feasibility of a multi-state randomized control trial (RCT) evaluating iAmHealthy, a rurally tailored pediatric obesity treatment delivered via synchronous televideo. This study's primary outcomes included the evaluation of participant retention and the efficacy of blinding. Each intervention arm was hypothesized to retain >75% of randomized participants and preserve blinding. Additionally, the intervention's preliminary effectiveness was evaluated by comparing changes in health outcomes. METHODS: Youth aged 6-11 years with a body mass index (BMI) percentile >/=85th and their caregivers were recruited from rural communities across four states participating in the Environmental Influences on Child Health Outcomes IDeA States Pediatric Clinical Trials Network. One hundred four dyads were randomly assigned to iAmHealthy plus newsletter or newsletter-only control. Retention rates for each treatment arm were calculated. Blinding was assessed via the New Blinding Index (NBI). Child and parent BMI, child physical activity, and child dietary intake were assessed at baseline and post-treatment (6 months). RESULTS: A one-sample test of proportions indicated retention rates exceeded 75% for iAmHealthy (87%, p = .027) and control (96%, p < .001). Blinding was successful for both groups [iAmHealthy NBI = -0.12, 95% confidence interval (CI): -0.13 to 0.36; control NBI = 0.02, 95% CI: -0.24 to 0.28]. There were no significant differences in health outcomes. CONCLUSIONS: This iAmHealthy multi-state feasibility RCT demonstrated high retention and successful blinding of assessors. Although the study was not powered to detect health outcome differences, iAmHealthy exhibited a tendency toward greater improvement or attenuated declines in child health outcomes, which supports the conduct of a future fully powered RCT. CLINICALTRIALS.GOV IDENTIFIER: NCT04142034, Registered: 10-25-2019; Trial name: Feasibility Trial of the iAmHealthy Intervention; https://clinicaltrials.gov/study/NCT04142034?cond=iamhealthy&checkSpell=false&rank=1. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Lancaster, Brittany D AU - Lancaster BD AUID- ORCID: 0000-0001-7556-743X AD - Department of Psychology, Mississippi State University, Mississippi State, MS, United States. AD - Department of Pediatrics, University of Kansas Medical Center, Kansas City, KS, United States. FAU - Chang, Di AU - Chang D AD - Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Lee, Jeannette AU - Lee J AD - Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Snowden, Jessica AU - Snowden J AD - Department of Pediatrics, The University of Tennessee Health Science Center, Memphis, TN, United States. FAU - Lawrence, Lora AU - Lawrence L AD - Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Eldredge Hubberd, DeAnn AU - Eldredge Hubberd D AD - Department of Biostatistics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Phan, Thao-Ly Tam AU - Phan TT AD - Department of Pediatrics, Nemours Children's Health, Wilmington, DE, United States. AD - Department of Pediatrics, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, United States. FAU - Hsia, Daniel S AU - Hsia DS AD - Clinical Trial Unit, Pennington Biomedical Research Center, Baton Rouge, LA, United States. AD - Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States. FAU - Hockett, Christine W AU - Hockett CW AUID- ORCID: 0000-0002-1665-6763 AD - Avera Research Institute, Sioux Falls, SD, United States. AD - Department of Pediatrics, University of South Dakota School of Medicine, Sioux Falls, SD, United States. FAU - Pyles, Lee AU - Pyles L AD - Department of Pediatrics, West Virginia University, Morgantown, WV, United States. FAU - Kong, Alberta S AU - Kong AS AD - Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM, United States. FAU - Roberts, James AU - Roberts J AD - Department of Pediatrics, Medical University of South Carolina College of Medicine, Charleston, SC, United States. FAU - McCulloh, Russell AU - McCulloh R AD - Department of Pediatrics, University of Nebraska Medical Center, Omaha, NE, United States. FAU - Darden, Paul M AU - Darden PM AD - Department of Family Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK, United States. AD - Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, AR, United States. FAU - Davis, Ann M AU - Davis AM AD - Department of Pediatrics, University of Kansas Medical Center, Kansas City, KS, United States. AD - Center for Children's Healthy Lifestyles & Nutrition, Kansas City, MO, United States. LA - eng SI - ClinicalTrials.gov/NCT04142034 GR - UG1 OD024942/CD/ODCDC CDC HHS/United States GR - UG1 OD030016/CD/ODCDC CDC HHS/United States GR - UG1 OD024956/CD/ODCDC CDC HHS/United States GR - UG1 OD030016/OD/NIH HHS/United States GR - UG1 OD024943/OD/NIH HHS/United States GR - UG1 OD024947/OD/NIH HHS/United States GR - UG1 OD024953/CD/ODCDC CDC HHS/United States GR - UG1 OD024942/OD/NIH HHS/United States GR - UG1 OD024950/CD/ODCDC CDC HHS/United States GR - U24 OD024957/OD/NIH HHS/United States GR - UG1 OD024958/CD/ODCDC CDC HHS/United States GR - UG1 OD024947/CD/ODCDC CDC HHS/United States GR - UG1 OD024945/OD/NIH HHS/United States GR - U24 OD024957/CD/ODCDC CDC HHS/United States GR - University of New Mexico Health Sciences Center/ GR - UG1 OD024945/CD/ODCDC CDC HHS/United States GR - UG1 OD024953/OD/NIH HHS/United States GR - UG1 OD024950/OD/NIH HHS/United States GR - UG1 OD024958/OD/NIH HHS/United States GR - UG1 OD024943/CD/ODCDC CDC HHS/United States GR - UG1 OD030019/OD/NIH HHS/United States GR - UG1 OD024956/OD/NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - J Pediatr Psychol JT - Journal of pediatric psychology JID - 7801773 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Feasibility Studies MH - *Rural Population MH - *Pediatric Obesity/therapy MH - Telemedicine MH - Body Mass Index MH - *Outcome Assessment, Health Care PMC - PMC13036881 MID - NIHMS2157875 OTO - NOTNLM OT - clinical trial OT - health behavior OT - obesity and weight management OT - pilot/feasibility trial OT - randomized controlled trial OT - school-age children COIS- Conflicts of interest: D.H. is a consultant for Eli Lilly's Pediatric Chronic Weight Management Portfolio. The other authors have no conflicts of interest relevant to this article to disclose. EDAT- 2026/02/26 15:24 MHDA- 2026/06/23 18:34 PMCR- 2026/04/01 CRDT- 2026/02/26 12:34 PHST- 2025/09/10 00:00 [received] PHST- 2025/12/19 00:00 [revised] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/06/23 18:34 [medline] PHST- 2026/02/26 15:24 [pubmed] PHST- 2026/02/26 12:34 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - 8499747 [pii] AID - 10.1093/jpepsy/jsag016 [doi] PST - ppublish SO - J Pediatr Psychol. 2026 Jun 1;51(6):472-482. doi: 10.1093/jpepsy/jsag016. PMID- 41745824 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260226 LR - 20260813 IS - 2305-6304 (Electronic) IS - 2305-6304 (Linking) VI - 14 IP - 2 DP - 2026 Feb 2 TI - Risk Assessment of Dibutyl Phthalate (DBP) and Bis(2-Ethylhexyl) Phthalate (DEHP) in Hot Pot Bases with a Hybrid Modeling Approach. LID - 10.3390/toxics14020150 [doi] LID - 150 AB - (1) Background: Hot pot bases are susceptible to phthalate (PAE) contamination due to their high lipid content. Standard risk models often fail to capture extreme values, leading to biased exposure estimates. This study characterized dibutyl phthalate (DBP) and bis(2-ethylhexyl) phthalate (DEHP) contamination using a hybrid modeling framework to ensure precise risk profiling. (2) Methods: A total of 91 samples were analyzed via GC-MS. Concentration data were fitted using traditional parametric, extreme value mixture (EVMM), and finite mixture models. Probabilistic dietary risks were assessed for Chinese demographic groups using 10,000-iteration Monte Carlo simulations. (3) Results: DEHP (detection rate: 55%) and DBP (32%) were best modeled by a two-component Gamma mixture and a Lognormal-Generalized Pareto distribution, respectively. These advanced models significantly outperformed conventional distributions in capturing upper-tail extremes. Crucially, all hazard quotients (HQs) remained below the safety threshold of 1, indicating acceptable risk, although children aged 7-13 exhibited the highest calculated risk (Max DEHP HQ = 0.68). (4) Conclusions: Although current exposure levels are within safe limits, the heavy-tailed distributions identify potential sporadic high-exposure events that traditional models overlook, specifically highlighting the relative vulnerability of children aged 7-13. This study validates that hybrid statistical approaches offer superior precision for analyzing skewed contamination data. Consequently, these findings provide a critical scientific basis for refining regulatory monitoring and implementing targeted source-tracking measures to mitigate long-tail food safety risks. FAU - Bian, Xiangyu AU - Bian X AUID- ORCID: 0009-0000-5121-6862 AD - Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210000, China. AD - Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210000, China. FAU - Huang, Siyu AU - Huang S AD - Key Laboratory of Condiment Supervision Technology, State Administration for Market Regulation, Chongqing Institute for Food and Drug Control, Chongqing 401121, China. FAU - Chen, Dongya AU - Chen D AD - Jiangsu Provincial Center for Disease Control and Prevention, 172 Jiangsu Road, Gulou District, Nanjing 210009, China. FAU - Jiang, Depeng AU - Jiang D AD - Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210000, China. AD - Department of Community Health Sciences, University of Manitoba, 7750 Bannatyne Ave, Winnipeg, MB R3T 2N2, Canada. FAU - Yang, Daoyuan AU - Yang D AD - NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, No. 37 Guangqu Road, Chaoyang District, Beijing 100022, China. FAU - Zhao, Yingzi AU - Zhao Y AD - Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210000, China. AD - Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210000, China. FAU - Liu, Zhujun AU - Liu Z AD - Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210000, China. AD - Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210000, China. FAU - Chen, Shiqi AU - Chen S AD - Key Laboratory of Condiment Supervision Technology, State Administration for Market Regulation, Chongqing Institute for Food and Drug Control, Chongqing 401121, China. FAU - Song, Yan AU - Song Y AD - NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, No. 37 Guangqu Road, Chaoyang District, Beijing 100022, China. FAU - Sui, Haixia AU - Sui H AUID- ORCID: 0000-0003-0405-0278 AD - NHC Key Laboratory of Food Safety Risk Assessment, China National Center for Food Safety Risk Assessment, No. 37 Guangqu Road, Chaoyang District, Beijing 100022, China. FAU - Sun, Jinfang AU - Sun J AUID- ORCID: 0009-0002-2278-016X AD - Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing 210000, China. AD - Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210000, China. LA - eng GR - 2023YFF1103900/National Key Research and Development Program of China/ GR - CFSA 523 Program/China Food Safety Talent Competency development Initiative/ PT - Journal Article DEP - 20260202 PL - Switzerland TA - Toxics JT - Toxics JID - 101639637 PMC - PMC12945265 OTO - NOTNLM OT - DBP OT - DEHP OT - dietary exposure OT - extreme value mixture model OT - mixture model OT - parametric probabilistic modeling OT - risk assessment COIS- The authors declare no conflicts of interest. EDAT- 2026/02/26 13:40 MHDA- 2026/02/26 13:41 PMCR- 2026/02/02 CRDT- 2026/02/26 09:23 PHST- 2026/01/20 00:00 [received] PHST- 2026/01/29 00:00 [revised] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/02/26 13:41 [medline] PHST- 2026/02/26 13:40 [pubmed] PHST- 2026/02/26 09:23 [entrez] PHST- 2026/02/02 00:00 [pmc-release] AID - toxics14020150 [pii] AID - toxics-14-00150 [pii] AID - 10.3390/toxics14020150 [doi] PST - epublish SO - Toxics. 2026 Feb 2;14(2):150. doi: 10.3390/toxics14020150. PMID- 41745709 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260226 LR - 20260813 IS - 2035-8385 (Print) IS - 2035-8377 (Electronic) IS - 2035-8385 (Linking) VI - 18 IP - 2 DP - 2026 Jan 28 TI - Ketogenic Strategies in Neonatal Hypoxic-Ischemic Encephalopathy-The Road to Opening Up: A Scoping Review. LID - 10.3390/neurolint18020024 [doi] LID - 24 AB - BACKGROUND: Neonatal hypoxic-ischemic encephalopathy remains a leading cause of neonatal mortality and long-term neurodevelopmental disability worldwide. Despite the widespread adoption of therapeutic hypothermia, a substantial proportion of affected infants experience death or significant neurological impairment. Given their metabolic vulnerability, ketogenic diet strategies and ketone bodies have emerged as potential adjunctive neuroprotective interventions. This scoping review aims to critically evaluate the mechanistic rationale, preclinical evidence, and clinical feasibility of ketogenic approaches. METHODS: A scoping review of the literature was conducted, including experimental and clinical studies investigating ketogenic diets, endogenous ketosis, and exogenous ketone supplementation in neonatal hypoxia-ischemia. Evidence was synthesized across mechanistic, preclinical, nutritional, and clinical domains, with particular attention to developmental context, timing of intervention, safety considerations, and translational relevance in the contest of therapeutic hypothermia. RESULTS: Preclinical studies consistently demonstrate that ketone bodies enhance cerebral energy metabolism, support mitochondrial function, reduce excitotoxic signaling, and attenuate oxidative stress and neuroinflammation in the immature brain. Neonatal models show preferential utilization of beta-hydroxybutyrate over glucose during hypoxic-ischemic stress, suggesting intrinsic metabolic advantages. Emerging evidence also supports potential long-term effects on epigenetic regulation and white matter development, although direct causal validation in neonatal HIE remains limited. Nutritional studies indicate that carefully monitored enteral and parenteral feeding is feasible in critically ill neonates, identifying a potential window for metabolic interventions. CONCLUSIONS: Ketogenic strategies represent a plausible, multimodal approach to targeting the metabolic and inflammatory sequelae of neonatal HIE. While current evidence is insufficient to support clinical implementation, this scoping review provides a hypothesis-generating framework to guide future translational research and the design of carefully controlled clinical trials in neonatal neurocritical care. FAU - Falsaperla, Raffaele AU - Falsaperla R AUID- ORCID: 0000-0002-4482-3506 AD - Department of Medical Science-Pediatrics, University of Ferrara, 44121 Ferrara, Italy. FAU - Sortino, Vincenzo AU - Sortino V AUID- ORCID: 0000-0002-0188-8430 AD - PhD Program in Innovative Innovative Technologies in Biomedical Sciences, University Kore of Enna, 94100 Enna, Italy. AD - National Council of Research, Institute for Research and Biomedical Innovation (IRIB), Unit of Catania, 95123 Catania, Italy. FAU - Malaventura, Cristina AU - Malaventura C AD - Department of Medical Science-Pediatrics, University of Ferrara, 44121 Ferrara, Italy. FAU - Fanaro, Silvia AU - Fanaro S AD - Department of Medical Science-Pediatrics, University of Ferrara, 44121 Ferrara, Italy. FAU - Ballardini, Elisa AU - Ballardini E AUID- ORCID: 0000-0002-8813-1835 AD - Department of Medical Science-Pediatrics, University of Ferrara, 44121 Ferrara, Italy. FAU - Martina, Aloise AU - Martina A AD - Faculty of Medicine and Surgery, University of Ferrara, 44121 Ferrara, Italy. FAU - Sapuppo, Annamaria AU - Sapuppo A AD - Unit of Pediatrics and Pediatric Emergency, Azienda Ospedaliero-Universitaria Policlinico "Rodolico-San Marco", San Marco Hospital, University of Catania, 95123 Catania, Italy. FAU - Suppiej, Agnese AU - Suppiej A AUID- ORCID: 0000-0001-5130-1450 AD - Department of Medical Science-Pediatrics, University of Ferrara, 44121 Ferrara, Italy. LA - eng PT - Journal Article PT - Review DEP - 20260128 PL - Switzerland TA - Neurol Int JT - Neurology international JID - 101551564 PMC - PMC12943511 OTO - NOTNLM OT - hypoxic-ischemic encephalopathy OT - ketogenic diet OT - ketone bodies OT - neonatal neuroprotection COIS- The authors declare no conflicts of interest. EDAT- 2026/02/26 13:40 MHDA- 2026/02/26 13:41 PMCR- 2026/01/28 CRDT- 2026/02/26 09:23 PHST- 2025/12/30 00:00 [received] PHST- 2026/01/25 00:00 [revised] PHST- 2026/01/26 00:00 [accepted] PHST- 2026/02/26 13:41 [medline] PHST- 2026/02/26 13:40 [pubmed] PHST- 2026/02/26 09:23 [entrez] PHST- 2026/01/28 00:00 [pmc-release] AID - neurolint18020024 [pii] AID - neurolint-18-00024 [pii] AID - 10.3390/neurolint18020024 [doi] PST - epublish SO - Neurol Int. 2026 Jan 28;18(2):24. doi: 10.3390/neurolint18020024. PMID- 41743552 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Machine learning-based prediction of IVF/ICSI outcomes in male factor infertility highlighting couple-level BMI. PG - 1772106 LID - 10.3389/fendo.2026.1772106 [doi] LID - 1772106 AB - BACKGROUND: Most clinical prediction models for assisted reproductive technology focus primarily on female ovarian reserve markers and often under-represent male factors and the metabolic status of both partners. Additionally, traditional parametric models may have limited ability to capture nonlinear patterns within reproductive data. This study aimed to develop and validate a machine learning (ML)-based model to predict clinical pregnancy outcomes in couples with male factor infertility undergoing IVF/ICSI, and to explore model interpretability using Shapley Additive exPlanations (SHAP). METHODS: This retrospective study analyzed 2,565 couples undergoing their first IVF/ICSI cycle for male factor infertility at Shanghai First Maternity and Infant Hospital between 2019 and 2025. The cohort was partitioned according to embryo transfer date, with the first 70% of cases assigned to the training set and the remaining 30% reserved as an temporal internal validation set. Feature selection was conducted using LASSO regression within the training set. Seven ML models, including LightGBM and Logistic Regression, were developed and optimized through 5-fold cross-validation. Model performance was evaluated using the area under the curve (AUC), accuracy, Brier score, and decision curve analysis. SHAP was employed to provide a visual interpretation of the optimal model. RESULTS: Five predictors were selected in the training set: female BMI, male BMI, basal FSH, AMH, and female age. In the temporal validation set, all models demonstrated comparable discriminative performance (AUC range: 0.840-0.857). LightGBM achieved an AUC of 0.857 (95% CI: 0.830-0.882), with an accuracy of 0.775 and specificity of 0.909. DeLong tests indicated no statistically significant differences in AUC between LightGBM and Random Forest (P = 0.918), XGBoost (P = 0.985), or logistic regression (P = 0.067). Based on its overall stability across discrimination, calibration (Brier score = 0.145), and clinical utility, LightGBM was selected for interpretability analysis. CONCLUSIONS: A LightGBM-based prediction model demonstrated reasonable performance for predicting IVF/ICSI outcomes in couples with male factor infertility. Within this dataset, couple-level metabolic features were strongly associated with model predictions alongside traditional ovarian reserve markers. These findings reflect predictive associations rather than causal effects and suggest that metabolic characteristics may warrant consideration in risk stratification and counseling. Prospective studies are needed to determine whether targeted interventions can improve clinical outcomes. CI - Copyright (c) 2026 Li, Gao and Li. FAU - Li, Hu AU - Li H AD - Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China. FAU - Gao, Jie AU - Gao J AD - Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China. FAU - Li, Yiran AU - Li Y AD - Centre for Assisted Reproduction, Shanghai Key Laboratory of Maternal Fetal Medicine, Shanghai Institute of Maternal-Fetal Medicine and Gynecologic Oncology, Shanghai First Maternity and Infant Hospital, School of Medicine, Tongji University, Shanghai, China. LA - eng PT - Journal Article DEP - 20260210 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - Male MH - Female MH - Retrospective Studies MH - *Fertilization in Vitro/methods MH - Pregnancy MH - *Sperm Injections, Intracytoplasmic MH - *Machine Learning MH - *Infertility, Male/therapy MH - Predictive Learning Models MH - *Body Mass Index MH - Adult MH - Pregnancy Outcome MH - Boosting Machine Learning Algorithms MH - Pregnancy Rate MH - Prediction Algorithms MH - Classification Algorithms PMC - PMC12929144 OTO - NOTNLM OT - body mass index OT - clinical pregnancy OT - lightGBM OT - machine learning OT - male infertility COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/26 15:21 MHDA- 2026/03/07 01:37 PMCR- 2026/02/10 CRDT- 2026/02/26 04:40 PHST- 2025/12/20 00:00 [received] PHST- 2026/01/23 00:00 [revised] PHST- 2026/01/26 00:00 [accepted] PHST- 2026/03/07 01:37 [medline] PHST- 2026/02/26 15:21 [pubmed] PHST- 2026/02/26 04:40 [entrez] PHST- 2026/02/10 00:00 [pmc-release] AID - 10.3389/fendo.2026.1772106 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Feb 10;17:1772106. doi: 10.3389/fendo.2026.1772106. eCollection 2026. PMID- 41743257 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260226 LR - 20260813 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 8 DP - 2026 TI - Validation of the behavioral regulation in cycling to and from school scale among students from Germany. PG - 1701435 LID - 10.3389/fspor.2026.1701435 [doi] LID - 1701435 AB - The prevalence of total physical activity among children and adolescents in Germany is reported to be low (D-) according to the country-specific Report Card from 2022. One potential strategy to increase physical activity is the promotion of cycling to and from school. To foster a more self-determined form of motivation among students, we developed a promising intervention grounded in the self-determination theory, as demonstrated in previous research. Here, we aimed to validate the "German behavioral regulation in cycling to and from school scale" focusing on construct and criterion validity as well as reliability to create a robust measurement instrument. Conducted in Southern Germany in 2021, this study involved 112 girls, 124 boys, and three students identifying as diverse (13.5 +/- 1.1 years) who attended a (sub)urban secondary school that provided an intermediate and/or high educational level. We were unable to validate the original first-order six-factor model. Instead, we successfully validated a newly developed first-order three-factor model, which demonstrated a good global model fit (GFI: 0.997, SRMR: 0.0313), measurement model invariance across gender (GFI: 0.986-0.994, SRMR: 0.0426-0.0596), and internal consistency (alpha: 0.846-0.927). For this new scale, both convergent (AVE: 0.582-0.762) and discriminant validity [Formula: see text] were established. Concurrent criterion validity was found acceptable by the correlation between the mean value for each of the three newly developed factors and the frequency of cycling to school (R = 0.616) as well as the increased likelihood of cycling to school based on mean levels of autonomous (p < 0.001; OR = 2.5 [CI 95 for OR: 1.9, 3.3]) and controlled (p < 0.001; OR = 1.7 [CI 95 for OR: 1.3, 2.4]) motivation. Consequently, we concluded that our study provides a valid and reliable scale measuring behavioral regulation in cycling to and from school, by applying a first-order three-factor model. Furthermore, researchers and practitioners, such as (physical education) teachers, could use this scale to assess the motivation for cycling to and from school in order to implement and evaluate contextual and tailored interventions. CI - (c) 2026 Schonbach, Marques, Peralta, Kleszczewska, Dzielska, Burgueno, Huertas-Delgado and Demetriou. FAU - Schonbach, Dorothea M I AU - Schonbach DMI AD - Department of Rehabilitation and Sports Medicine, Hannover Medical School, Hanover, Germany. AD - TUM School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Marques, Adilson AU - Marques A AD - Centro Interdisciplinar de Performance Humana (CIPER), Faculdade de Motricidade Humana, Universidade de Lisboa, Lisbon, Portugal. AD - Nucleo de Investigacion en Ciencias del Movimiento, Universidad Arturo Prat, Iquique, Chile. FAU - Peralta, Miguel AU - Peralta M AD - Centro Interdisciplinar de Performance Humana (CIPER), Faculdade de Motricidade Humana, Universidade de Lisboa, Lisbon, Portugal. FAU - Kleszczewska, Dorota AU - Kleszczewska D AD - Department of Health Sociology, Education and Medical Communication, Institute of Mother and Child, Warsaw, Poland. FAU - Dzielska, Anna AU - Dzielska A AD - Department of Child and Adolescent Health, Institute of Mother and Child, Warsaw, Poland. FAU - Burgueno, Rafael AU - Burgueno R AD - Department of Didactics of Languages, Arts and Sport, University of Malaga, Malaga, Spain. FAU - Huertas-Delgado, Francisco Javier AU - Huertas-Delgado FJ AD - Teacher Training Centre La Inmaculada, University of Granada, Granada, Spain. FAU - Demetriou, Yolanda AU - Demetriou Y AD - Institute of Sports Science, University of Tubingen, Tubingen, Germany. LA - eng PT - Journal Article DEP - 20260211 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC12931929 OTO - NOTNLM OT - autonomous motivation OT - bicycling to school OT - measurement instrument OT - organismic integration theory OT - self-determination theory COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/26 13:40 MHDA- 2026/02/26 13:41 PMCR- 2026/02/11 CRDT- 2026/02/26 04:37 PHST- 2025/09/08 00:00 [received] PHST- 2026/01/07 00:00 [revised] PHST- 2026/01/14 00:00 [accepted] PHST- 2026/02/26 13:41 [medline] PHST- 2026/02/26 13:40 [pubmed] PHST- 2026/02/26 04:37 [entrez] PHST- 2026/02/11 00:00 [pmc-release] AID - 10.3389/fspor.2026.1701435 [doi] PST - epublish SO - Front Sports Act Living. 2026 Feb 11;8:1701435. doi: 10.3389/fspor.2026.1701435. eCollection 2026. PMID- 41742298 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 1756-0500 (Electronic) IS - 1756-0500 (Linking) VI - 19 IP - 1 DP - 2026 Feb 25 TI - Patient-reported satisfaction after ultrasound-assisted liposuction with infra-areolar excision for gynecomastia: a retrospective cross-sectional from Palestine. LID - 10.1186/s13104-026-07735-4 [doi] LID - 154 AB - BACKGROUND: Gynecomastia can have significant psychosocial impacts. Ultrasound-assisted liposuction (UAL) combined with glandular excision has emerged as a preferred technique for contour correction with minimal scarring. This study evaluates surgical outcomes and patient satisfaction following UAL with glandular excision. METHODOLOGY: This was a retrospective cross-sectional study of male patients who underwent bilateral gynecomastia correction using ultrasound-assisted liposuction with infra-areolar excision between September 2022 and June 2024 in Palestine. Clinical and perioperative variables were extracted from medical records, and outcomes were supplemented with patient-reported satisfaction using the validated Arabic BODY-Q chest and nipple modules collected via an online follow-up questionnaire. Nonparametric group comparisons, Spearman correlation, and multivariable linear regression were used to identify predictors of satisfaction (SPSS v21). RESULTS: A total of 133 patients were included (median age 28 years; median BMI 26 kg/m(2)). Most cases were physiological and primarily Simon grade IIa/IIb. The median aspirated fat volume was 350 Ml. Postoperative complications were generally infrequent; the most common were asymmetry, redundant skin, hematoma, and contour irregularity, and 12% of patients underwent revision surgery. Overall satisfaction was high in both BODY-Q domains. Chest satisfaction decreased with increasing gynecomastia grade and was independently lower in patients with contour irregularity, undesirable scars, redundant skin, and recurrence. Nipple satisfaction was independently lower with contour irregularity, undesirable scars, redundant skin, and nipple-areola complex adherence. Chest and nipple satisfaction scores were positively correlated. CONCLUSION: Ultrasound-assisted liposuction with infra-areolar excision achieved high patient-reported satisfaction with a low-to-moderate complication profile in this Palestinian cohort. Satisfaction was driven primarily by postoperative aesthetic factors-particularly contour quality, scarring, redundant skin, and recurrence, highlighting key targets for surgical optimization and patient counselling. CI - (c) 2026. The Author(s). FAU - Aljamal, Mahdi AU - Aljamal M AUID- ORCID: 0000-0003-1809-6138 AD - Department of Surgery, Faculty of Medicine and Health Sciences, Arab American University, Jenin, Palestine. Mahdi.aljamal@aaup.edu. FAU - Shakhshir, Ali AU - Shakhshir A AUID- ORCID: 0000-0003-4138-8497 AD - Department of Medicine, Faculty of Medicine and Health Sciences, Arab American University, Jenin, Palestine. shakhshirali@gmail.com. FAU - Sulaiman, Amro J A AU - Sulaiman AJA AUID- ORCID: 0009-0003-1856-3856 AD - Faculty of Medicine and Health Sciences, Arab American University, Jenin, Palestine. FAU - Zeidalkilani, Mohammed A AU - Zeidalkilani MA AUID- ORCID: 0009-0006-0335-1860 AD - Faculty of Medicine and Health Sciences, Arab American University, Jenin, Palestine. LA - eng PT - Journal Article DEP - 20260225 PL - England TA - BMC Res Notes JT - BMC research notes JID - 101462768 SB - IM MH - Humans MH - Male MH - *Gynecomastia/surgery MH - Retrospective Studies MH - *Patient Satisfaction/statistics & numerical data MH - *Lipectomy/methods MH - Cross-Sectional Studies MH - Adult MH - Young Adult MH - Adolescent MH - Patient Reported Outcome Measures MH - Middle Aged PMC - PMC13040969 OTO - NOTNLM OT - Body-Q OT - Cross-sectional retrospective study OT - Glandularexcision OT - Gynecomastia OT - Palestine OT - Satisfaction OT - Ultrasound-assisted liposuction (UAL) COIS- Declarations. Ethics approval and consent to participate: The research protocol was approved by the IRB committee of the Arab American University (Reference number: J-2025/A/7/N). The study adhered to the ethical principles outlined in the Declaration of Helsinki. Before data collection, the researchers provided a verbal explanation of the study's purpose to each potential participant, and informed consent was obtained from all subjects. Participants were also informed of their right to withdraw from the study at any time without facing any consequences. Consent of publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/26 15:23 MHDA- 2026/04/01 07:04 PMCR- 2026/02/25 CRDT- 2026/02/26 00:04 PHST- 2025/08/30 00:00 [received] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/04/01 07:04 [medline] PHST- 2026/02/26 15:23 [pubmed] PHST- 2026/02/26 00:04 [entrez] PHST- 2026/02/25 00:00 [pmc-release] AID - 10.1186/s13104-026-07735-4 [pii] AID - 7735 [pii] AID - 10.1186/s13104-026-07735-4 [doi] PST - epublish SO - BMC Res Notes. 2026 Feb 25;19(1):154. doi: 10.1186/s13104-026-07735-4. PMID- 41742260 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1475-2891 (Electronic) IS - 1475-2891 (Linking) VI - 25 IP - 1 DP - 2026 Feb 25 TI - Agreement Of A 24-hour food record and relative validity of a food frequency questionnaire compared with urinary biomarkers of sodium, potassium, and protein intake. LID - 10.1186/s12937-026-01298-7 [doi] LID - 32 AB - BACKGROUND: Dietary assessment methods such as food frequency questionnaires (FFQs) and 24-hour food records (24hFRs) are widely used in population-based studies due to their feasibility and relatively low cost. However, these self-reported methods are subject to measurement errors, including recall bias and misreporting, which may vary across individuals and seasons. In contrast, 24-hour urinary excretion (24UE) of sodium, potassium, and nitrogen is considered a more objective biomarker of intake and is often used as a reference method in validation studies. AIM: This study aimed to evaluate the agreement of a 24-hour food record (24hFR) and the relative validity of a food frequency questionnaire (FFQ) against recovery urinary biomarkers of sodium, potassium, and urea-derived protein intake. METHOD: This observational, cross-sectional validation study included a total of 37 healthy adult women aged 18-44 years. Information on participants' sociodemographic characteristics, dietary habits, and physical activity levels was collected, and anthropometric measurements were performed by the researcher. In addition, 24-hour food records (24hFR) and 24-hour urine excretion (24UE) samples were collected twice in summer and twice in winter on nonconsecutive days with a 14-day interval, resulting in a total of four collections per participant, and food consumption frequencies (FFQs) were determined. RESULTS: The most commonly used salt type among the participants was iodized table salt (56.8%). The mean sodium intake estimated from the 24-hour food record was significantly higher in the winter (3142.2 +/- 905.7 mg/day) compared to the summer (2479.6 +/- 793.5 mg/day) (p < 0.05). The mean sodium and potassium intakes estimated by the 24-hour food record were similar to those determined by urinary sodium and potassium excretion at the group level in both seasons, although correlations at the individual level were weak. The difference between the measurement methods for sodium and potassium values ​​(FFQ, 24hFR, 24UE) in summer and winter was due to the frequency of food consumption. Protein intake estimated by the FFQ and food record methods was comparable; however, protein intake calculated from urinary excretion was higher than the estimated values. CONCLUSION: In conclusion, the 24-hour food record method, which is widely used in nutritional assessment, showed closer agreement with urinary sodium and potassium excretion at the group (mean) level rather than at the individual ranking level, but underestimated protein intake in this study. These findings highlight the need for complementary biochemical markers when assessing protein consumption in population-based dietary surveys. FAU - Kurtgil, Seren AU - Kurtgil S AUID- ORCID: 0000-0002-2289-2594 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, SANKO University, Incili Pinar, Gazi Muhtar Pasa Boulevard. No: 36, Sehitkamil/Gaziantep, 27090, Turkey. serenkurtgil@gmail.com. FAU - Erbagci, Mustafa Anil AU - Erbagci MA AUID- ORCID: 0000-0002-7842-5741 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Hasan Kalyoncu University, Airport Road 8th Km, 27000, Sahinbey/Gaziantep, Turkey. FAU - Pekcan, Ayla Gulden AU - Pekcan AG AUID- ORCID: 0000-0002-2037-3037 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Lokman Hekim University, Sogutozu Neighborhood 2185 Street No:20/J, Cankaya, Ankara, 06510, Turkey. LA - eng GR - 223S330/TUBITAK 1002-A Program/ PT - Comparative Study PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20260225 PL - England TA - Nutr J JT - Nutrition journal JID - 101152213 RN - 0 (Biomarkers) RN - 0 (Dietary Proteins) RN - 0 (Potassium, Dietary) RN - 0 (Sodium, Dietary) RN - 9NEZ333N27 (Sodium) RN - RWP5GA015D (Potassium) SB - IM MH - Humans MH - Female MH - Biomarkers/urine MH - Adult MH - *Diet Records MH - *Dietary Proteins/administration & dosage/urine MH - *Potassium, Dietary/urine/administration & dosage MH - Young Adult MH - Cross-Sectional Studies MH - *Sodium, Dietary/urine/administration & dosage MH - Adolescent MH - Reproducibility of Results MH - Surveys and Questionnaires MH - Nutrition Assessment MH - Sodium/urine MH - Seasons MH - Potassium/urine PMC - PMC13040766 OTO - NOTNLM OT - 24-hour food record OT - 24-hour urine excretion OT - Potassium OT - Protein OT - Sodium OT - Urea COIS- Declarations. Ethics approval and consent to participate: Ethics committee approval for the study was obtained from the SANKO University Clinical Research Ethics Committee (decision number 2023/07 - 01). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/26 15:23 MHDA- 2026/06/28 00:38 PMCR- 2026/02/25 CRDT- 2026/02/26 00:03 PHST- 2025/11/13 00:00 [received] PHST- 2026/02/22 00:00 [accepted] PHST- 2026/06/28 00:38 [medline] PHST- 2026/02/26 15:23 [pubmed] PHST- 2026/02/26 00:03 [entrez] PHST- 2026/02/25 00:00 [pmc-release] AID - 10.1186/s12937-026-01298-7 [pii] AID - 1298 [pii] AID - 10.1186/s12937-026-01298-7 [doi] PST - epublish SO - Nutr J. 2026 Feb 25;25(1):32. doi: 10.1186/s12937-026-01298-7. PMID- 41742110 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Feb 26 TI - The correlation between maternal knowledge of breastfeeding, self-efficacy of breastfeeding and knowledge and attitudes towards donated human milk: a cross-sectional study. LID - 10.1186/s12884-026-08864-1 [doi] LID - 369 AB - BACKGROUND: The World Health Organization (WHO) endorses breast milk as the optimal nutritional source for infants. When maternal lactation is insufficient due to multifactorial causes or breastfeeding is contraindicated by maternal illness, donated human milk (DHM) is recommended as the preferred alternative feeding strategy. This study aims to investigate correlations between maternal breastfeeding knowledge, breastfeeding self-efficacy, and DHM-related knowledge/attitudes, and to identify factors influencing maternal DHM knowledge and attitudes. Findings will inform targeted strategies to optimize human milk donation practices. METHODS: A cross-sectional study was conducted among postpartum women attending 42-day postnatal check-ups between January and June 2025. Participants completed a sociodemographic questionnaire and three validated instruments: the Questionnaire for the Knowledge, Attitudes, and Practices of Human Milk Donation in Hospital Puerperants, Breastfeeding Knowledge Questionnaire (BKQ), and Short Form of the Breastfeeding Self-Efficacy Scale (BSES-SF). Multiple linear regression analyses were performed to identify significant predictors of DHM-related knowledge and attitudes. RESULTS: Of 188 valid responses, mothers demonstrated moderate-to-high DHM knowledge (mean +/- SD: 8.42 +/- 2.78) and positive DHM attitudes (mean +/- SD: 40.21 +/- 5.03). Multiple linear regression revealed that BKQ scores were significantly associated with DHM knowledge scores (p < 0.05). Additionally, longer maternity leave duration, higher BKQ scores, and higher BSES-SF scores were independently associated with more favorable DHM attitudes (p < 0.05 for all). CONCLUSIONS: Postpartum women with longer maternity leave duration represent key target groups for DHM promotion. Healthcare providers should prioritize interventions to enhance postpartum women's breastfeeding knowledge and self-efficacy, as these factors may significantly improve maternal engagement in breast milk donation. TRIAL REGISTRATION: The study was registered at the Chinese Clinical Trial Registry (registration number: ChiCTR2500098424; date of first registration: 07/03/2025). CI - (c) 2026. The Author(s). FAU - Li, Xiaoting AU - Li X AD - Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. FAU - Liu, Guihua AU - Liu G AD - Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. FAU - Zheng, Yueying AU - Zheng Y AD - Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. FAU - Lin, Huimin AU - Lin H AD - Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. FAU - Wang, Ruidi AU - Wang R AD - The School of Nursing, Fujian Medical University, Fuzhou, China. FAU - Lin, Ying AU - Lin Y AD - Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China. ly51398@163.com. LA - eng GR - 2023QH1211/Startup Fund for Scientific Research, Fujian Medical University/ PT - Journal Article DEP - 20260226 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - *Breast Feeding/psychology MH - Cross-Sectional Studies MH - *Health Knowledge, Attitudes, Practice MH - Adult MH - *Self Efficacy MH - *Milk, Human MH - Surveys and Questionnaires MH - *Mothers/psychology MH - Postpartum Period/psychology MH - Young Adult PMC - PMC13041162 OTO - NOTNLM OT - Breastfeeding OT - Breastfeeding knowledge OT - Breastfeeding self-efficacy OT - Donated human milk OT - Influencing factors COIS- Declarations. Ethics approval and consent to participate: The study was approved by the ethics committee of Fujian Maternity and Child Health Hospital (No.: 2024KY153). All participants provided written informed consent prior to enrolment in the study. Our study adhered to the Declaration of Helsinki to this effect. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/26 15:22 MHDA- 2026/04/02 06:30 PMCR- 2026/02/26 CRDT- 2026/02/25 23:57 PHST- 2025/12/04 00:00 [received] PHST- 2026/02/20 00:00 [accepted] PHST- 2026/04/02 06:30 [medline] PHST- 2026/02/26 15:22 [pubmed] PHST- 2026/02/25 23:57 [entrez] PHST- 2026/02/26 00:00 [pmc-release] AID - 10.1186/s12884-026-08864-1 [pii] AID - 8864 [pii] AID - 10.1186/s12884-026-08864-1 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Feb 26;26(1):369. doi: 10.1186/s12884-026-08864-1. PMID- 41741966 OWN - NLM STAT- In-Process LR - 20260921 IS - 1468-3148 (Electronic) IS - 1360-2322 (Print) IS - 1360-2322 (Linking) VI - 39 IP - 2 DP - 2026 Mar TI - Feasibility and Preliminary Impacts of a Stress Reduction Intervention for Caregivers of Adolescents and Young Adults With Intellectual and Developmental Disabilities. PG - e70202 LID - 10.1111/jar.70202 [doi] AB - BACKGROUND: Family caregivers of individuals with intellectual and developmental disabilities often experience chronic stress and poor mental and physical health. This study examined the feasibility of a 12-week single-arm intervention to reduce caregiver stress. METHODS: The caregiver intervention included a yoga class and informational support group. Feasibility measures included recruitment, attendance, retention, fidelity and acceptability (interviews). Exploratory impacts on perceived and physiological stress (salivary cortisol), social support, caregiver strain, family empowerment, sleep, physical activity and body mass index were assessed by percent change across the intervention. RESULTS: Twenty caregivers enrolled (95% retained) and participants attended 67% of sessions. Intervention fidelity was 95%. Semi-structured interviews revealed high acceptability of the intervention. Perceived stress decreased by 5.8% and cortisol decreased by 24.1%. Changes in all but one exploratory outcome were in desirable directions. CONCLUSIONS: The intervention was feasible and acceptable among participants with positive initial effects on the majority of exploratory outcomes. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Bodde, Amy E AU - Bodde AE AUID- ORCID: 0000-0002-8143-8105 AD - Department of Internal Medicine, The University of Kansas Medical Center, Kansas City, Kansas, USA. FAU - Helsel, Brian C AU - Helsel BC AUID- ORCID: 0000-0003-3362-3581 AD - Department of Neurology, The University of Kansas Medical Center, Kansas City, Kansas, USA. FAU - Willis, Erik AU - Willis E AD - UNC Center for Health Promotion and Disease Prevention, University of North Carolina, Chapel Hill, North Carolina, USA. FAU - Montgomery, Robert N AU - Montgomery RN AUID- ORCID: 0000-0002-1423-0590 AD - Department of Biostatistics and Data Science, The University of Kansas Medical Center, Kansas City, Kansas, USA. FAU - Ptomey, Lauren T AU - Ptomey LT AD - Department of Internal Medicine, The University of Kansas Medical Center, Kansas City, Kansas, USA. FAU - Forseth, Bethany AU - Forseth B AUID- ORCID: 0000-0002-4321-6034 AD - Department of Physical Therapy, Rehabilitation Science, and Athletic Training, The University of Kansas Medical Center, Kansas City, Kansas, USA. LA - eng GR - U54 HD090216/HD/NICHD NIH HHS/United States GR - HD090216/National Institute of Child Health and Development (NICHD)/ GR - KL2 TR002367/TR/NCATS NIH HHS/United States GR - Center for Children's Healthy Lifestyles and Nutrition Kansas City/ GR - KL2TR002367/TR/NCATS NIH HHS/United States GR - K01 AG083130/AG/NIA NIH HHS/United States PT - Journal Article PL - England TA - J Appl Res Intellect Disabil JT - Journal of applied research in intellectual disabilities : JARID JID - 9613616 SB - IM PMC - PMC13077726 MID - NIHMS2156723 OAB - We evaluated whether we could deliver a yoga and informational support group programme for caregivers of people with intellectual and developmental disabilities. We were able to complete a 12-week in-person programme, and caregivers improved their stress levels, saw positive changes in other health outcomes and reported enjoying the programme. Caregivers may benefit from stress-reducing programmes which include yoga and an informational support group. Additional studies should test these programmes in larger groups. OABL- eng OTO - NOTNLM OT - caregivers OT - carers OT - intellectual and developmental disabilities OT - social support OT - stress OT - yoga COIS- Conflicts of Interest Dr. Lauren T. Ptomey received personal fees from Healthy Weight Research Network for Children with ASD and DD, outside the submitted work. EDAT- 2026/02/26 15:22 MHDA- 2026/02/26 15:22 PMCR- 2026/04/14 CRDT- 2026/02/25 23:33 PHST- 2025/06/30 00:00 [revised] PHST- 2024/08/21 00:00 [received] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/02/26 15:22 [medline] PHST- 2026/02/26 15:22 [pubmed] PHST- 2026/02/25 23:33 [entrez] PHST- 2026/04/14 00:00 [pmc-release] AID - 10.1111/jar.70202 [doi] PST - ppublish SO - J Appl Res Intellect Disabil. 2026 Mar;39(2):e70202. doi: 10.1111/jar.70202. PMID- 41741810 OWN - NLM STAT- MEDLINE DCOM- 20260430 LR - 20260813 IS - 1432-0428 (Electronic) IS - 0012-186X (Print) IS - 0012-186X (Linking) VI - 69 IP - 6 DP - 2026 Jun TI - GlucoseGo: a simple tool to predict hypoglycaemia during exercise in type 1 diabetes. PG - 1468-1481 LID - 10.1007/s00125-026-06692-8 [doi] AB - AIMS/HYPOTHESIS: This study aimed to develop an accessible tool, derived using machine learning, to predict hypoglycaemia risk at the start of exercise and to provide clear, rapid risk assessment to support safer participation in exercise. METHODS: Data from four diverse studies were combined, encompassing 16,430 exercise sessions from 834 participants aged 12-80 years using various insulin delivery methods. The XGBoost algorithm was used to develop two models: a comprehensive model and a simplified model for predicting hypoglycaemia during exercise. RESULTS: The comprehensive model (406 variables) achieved a mean ROC AUC of 0.89. The simplified model, using only starting glucose, exercise duration and glucose trend arrows, achieved a comparable ROC AUC of 0.87. The simplified model performed consistently across exercise types and insulin delivery methods. In collaboration with individuals with type 1 diabetes, this model was translated into GlucoseGo, a user-friendly traffic-light heatmap displaying hypoglycaemia risk based on the three variables. CONCLUSIONS/INTERPRETATION: The GlucoseGo heatmap provides a practical, accessible tool for predicting hypoglycaemia risk immediately before exercise. It may empower individuals with type 1 diabetes to exercise more safely, reduce hypoglycaemic episodes, and increase engagement in physical activity. CI - (c) 2026. The Author(s). FAU - Russon, Catherine L AU - Russon CL AUID- ORCID: 0000-0001-6785-6477 AD - University of Exeter Medical School, University of Exeter, Exeter, UK. c.russon@exeter.ac.uk. FAU - Allen, Michael J AU - Allen MJ AUID- ORCID: 0000-0002-8746-9957 AD - University of Exeter Medical School, University of Exeter, Exeter, UK. FAU - Cockcroft, Emma AU - Cockcroft E AUID- ORCID: 0000-0003-3798-9492 AD - University of Exeter Medical School, University of Exeter, Exeter, UK. FAU - Pemberton, John S AU - Pemberton JS AUID- ORCID: 0000-0002-0730-7879 AD - Department of Endocrinology and Diabetes, Birmingham Women's and Children's Foundation Trust, Birmingham, UK. FAU - Frohock, Anne-Marie AU - Frohock AM AUID- ORCID: 0000-0001-7159-2283 AD - Oxfordshire Children's Diabetes Service, Oxford University Hospitals NHS Foundation Trust, Oxford, UK. FAU - Vaughan, Neil AU - Vaughan N AUID- ORCID: 0000-0001-5038-6560 AD - University of Exeter Medical School, University of Exeter, Exeter, UK. FAU - Pulsford, Richard M AU - Pulsford RM AUID- ORCID: 0000-0001-6880-7597 AD - University of Exeter Medical School, University of Exeter, Exeter, UK. FAU - Andrews, Robert C AU - Andrews RC AUID- ORCID: 0000-0003-4939-1738 AD - University of Exeter Medical School, University of Exeter, Exeter, UK. LA - eng PT - Journal Article PT - Observational Study DEP - 20260225 PL - Germany TA - Diabetologia JT - Diabetologia JID - 0006777 RN - 0 (Blood Glucose) RN - 0 (Insulin) SB - IM MH - Humans MH - Male MH - Female MH - Child MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged MH - Aged MH - Aged, 80 and over MH - *Diabetes Mellitus, Type 1/blood/complications/drug therapy MH - *Blood Glucose Self-Monitoring/instrumentation/methods MH - ROC Curve MH - *Hypoglycemia/diagnosis/etiology/prevention & control MH - Risk Assessment/methods MH - Boosting Machine Learning Algorithms MH - Predictive Learning Models MH - *Exercise/physiology MH - *Blood Glucose/analysis MH - Insulin Infusion Systems MH - Insulin/administration & dosage MH - Retrospective Studies MH - Datasets as Topic PMC - PMC13109191 OTO - NOTNLM OT - Continuous glucose monitoring OT - Decision support OT - Exercise OT - Hypoglycaemia OT - Machine learning OT - Risk prediction OT - Self-management OT - Type 1 diabetes COIS- Acknowledgements: First, we wish to express our gratitude to the participants of the studies. Without your contribution, this research would not have been possible. We also wish to thank A. Jones for critical evaluation of our findings. This study was conducted with the support of the NIHR Exeter Biomedical Research Centre (BRC). This publication is based on research using data from the Type 1 Diabetes EXercise Initiative (T1DEXI) and Type 1 Diabetes EXercise Initiative Pediatric (T1DEXIP) studies that have been made available through Vivli Inc. Vivli has not contributed to or approved, and is not in any way responsible for, the contents of this publication. During the course of preparing this work, the authors used ChatGPT and Copilot for the purpose of summarising research papers, text editing and providing code snippets. Following the use of this tool/service, the authors formally reviewed the content for its accuracy and edited it as necessary. The authors take full responsibility for all the content of this publication. Data availability: The T1DEXI and T1DEXIP datasets are available through application to Vivli Inc. ( https://vivli.org/ ). The EXTOD-101 and EXTOD-Education datasets are available from the study investigators upon reasonable request. Code availability: All code for this project is openly available in a GitHub repository ( https://github.com/cafoala/glucoseGo ). Funding: This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors. Authors' relationships and activities: JSP has served on advisory boards for Abbott and Roche and has received speaker fees from Abbott, Dexcom and Insulet within the last three years. He is also a faculty member of the EXercise in Type One Diabetes group. RCA has received research funding from Novo Nordisk Healthcare Organisation within the last three years and has received honoraria from Novo Nordisk, AstraZeneca and Eli Lilly for educational talks on diet and exercise to healthcare professionals. He is a co-founder of the EXercise in Type One Diabetes group. The remaining authors declare that there are no relationships or activities that might bias, or be perceived to bias, their work. Contribution statement: All authors were involved in the conception, design and conduct of the study, as well as the analysis and interpretation of the results. CLR wrote the code and the first draft of the manuscript. MJA served as the technical advisor for code and data analysis, RCA acted as the clinical advisor, and RMP provided expertise as the sports science advisor. All authors edited, reviewed and approved the final version of the manuscript. CLR is the guarantor of this work, and, as such, had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis. EDAT- 2026/02/26 15:25 MHDA- 2026/04/24 12:36 PMCR- 2026/02/25 CRDT- 2026/02/25 23:26 PHST- 2025/08/22 00:00 [received] PHST- 2025/12/16 00:00 [accepted] PHST- 2026/04/24 12:36 [medline] PHST- 2026/02/26 15:25 [pubmed] PHST- 2026/02/25 23:26 [entrez] PHST- 2026/02/25 00:00 [pmc-release] AID - 10.1007/s00125-026-06692-8 [pii] AID - 6692 [pii] AID - 10.1007/s00125-026-06692-8 [doi] PST - ppublish SO - Diabetologia. 2026 Jun;69(6):1468-1481. doi: 10.1007/s00125-026-06692-8. Epub 2026 Feb 25. PMID- 41741555 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Feb 25 TI - Nitrate measurement and age-specific carcinogenic and non-carcinogenic risk assessment in commonly consumed vegetables from Khuzestan Province, Iran. LID - 10.1038/s41598-026-40722-0 [doi] LID - 11030 AB - This study investigated nitrate concentrations and associated health risks in four commonly consumed vegetables in Iran. A total of 282 samples of cucumber, tomato, onion, and potato were randomly collected from markets across Khuzestan Province, and analyzed. Fresh vegetables were washed, homogenized, extracted, and analyzed using an optimized zinc-reduction Griess reaction-based spectrophotometric method (lambdamax = 537 nm) validated against high-performance liquid chromatography (HPLC). The highest levels of nitrate were observed in potato (87.107 +/- 32.270 mg/kg) and cucumber (80.366 +/- 30.099 mg/kg). Non-carcinogenic risk assessment showed target hazard quotients (THQ) and hazard index (HI) well below 1.0 for both adults and children. Lifetime carcinogenic risk (CR) exceeded the conservative 1 x 10-(6) threshold only for cucumber in adults and for cucumber, potato, and tomato in children. The total carcinogenic risk (TCR) was unacceptable. These findings suggest that, despite acceptable non-carcinogenic risk, long-term consumption of these vegetables may pose an unacceptable carcinogenic risk, particularly to children. Regular monitoring of nitrate levels in vegetables and other dietary sources (e.g., water and processed meat) is therefore recommended. However, some reducing agents in vegetables and our body can convert nitrate to the more toxic metabolite nitrite. Therefore, factors such as dietary composition and individual physiological responses to nitrate warrant further investigation to refine risk assessments. FAU - Pakravan, Niloufar AU - Pakravan N AD - Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. AD - Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. FAU - Noori, Seyyed Mohammad Ali AU - Noori SMA AD - Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. AD - Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. FAU - Salehcheh, Maryam AU - Salehcheh M AD - Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. AD - Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. FAU - Darvishnejad, Mohammad AU - Darvishnejad M AD - Nutrition Health Research Center, Food and Drug Control Laboratory, Hamadan University of Medical Science, Hamadan, Iran. FAU - Seyedtabib, Maryam AU - Seyedtabib M AD - Infectious Ophthalmologic Research Center, Department of Biostatistics and Epidemiology, School of Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. FAU - Mohammadi, Elaheh AU - Mohammadi E AD - Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. AD - Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. FAU - Khodayar, Mohammad Javad AU - Khodayar MJ AD - Toxicology Research Center, Medical Basic Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. khodayar-mj@ajums.ac.ir. AD - Department of Toxicology, School of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. khodayar-mj@ajums.ac.ir. LA - eng GR - TRC-0133/Ahvaz Jundishapur University of Medical Sciences/ PT - Journal Article DEP - 20260225 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Nitrates) RN - 0 (Carcinogens) SB - IM MH - *Vegetables/chemistry MH - Iran MH - *Nitrates/analysis MH - Risk Assessment MH - *Carcinogens/analysis MH - Humans MH - Adult MH - Cucumis sativus/chemistry MH - Chromatography, High Pressure Liquid MH - Child PMC - PMC13043668 OTO - NOTNLM OT - Carcinogenic OT - Nitrate OT - Risk assessment OT - Spectrophotometry OT - Vegetables COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: All sample collections were performed in compliance with relevant local regulations and guidelines for food and agricultural product sampling. The study protocol was approved by Ahvaz Jundishapur University of Medical Sciences (AJUMS) (Ethical code: IR.AJUMS.REC.1401.413). EDAT- 2026/02/26 15:21 MHDA- 2026/06/27 12:37 PMCR- 2026/02/25 CRDT- 2026/02/25 23:19 PHST- 2025/10/13 00:00 [received] PHST- 2026/02/16 00:00 [accepted] PHST- 2026/06/27 12:37 [medline] PHST- 2026/02/26 15:21 [pubmed] PHST- 2026/02/25 23:19 [entrez] PHST- 2026/02/25 00:00 [pmc-release] AID - 10.1038/s41598-026-40722-0 [pii] AID - 40722 [pii] AID - 10.1038/s41598-026-40722-0 [doi] PST - epublish SO - Sci Rep. 2026 Feb 25;16(1):11030. doi: 10.1038/s41598-026-40722-0. PMID- 41741494 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260325 LR - 20260813 IS - 2396-8370 (Electronic) IS - 2396-8370 (Linking) VI - 10 IP - 1 DP - 2026 Feb 25 TI - Transcriptomic comparison of human intestinal organoids and Caco-2 cells in modeling nutrient absorption: insights from infant formula and breast milk. LID - 10.1038/s41538-025-00672-9 [doi] LID - 101 AB - Infant nutrition is crucial for early development, with breast milk regarded as the gold standard. However, replicating its nutrient absorption and metabolic outcomes in infant formula remains challenging. This study utilized transcriptomic analysis to compare human small intestinal organoids (SIOs) and Caco-2 cells as models for nutrient absorption across three types of infant formula and breast milk. RNA sequencing revealed that SIOs exhibited greater Euclidean distance distributions and achieved more precise hierarchical clustering compared to Caco-2 cells. Differential expression analysis identified a higher number of differentially expressed genes in SIOs, along with significant enrichment of growth and developmental pathways, including embryonic morphogenesis, providing a closer approximation of human intestinal processes. Moreover, our analysis demonstrated that breast milk exhibits unique metabolic signatures distinct from all infant formulas evaluated, reinforcing its established role as the nutritional gold standard. Subsequent toxicological assessment revealed elevated oxidative stress-related metabolites in formulas processed via two-step wet blending, suggesting potential long-term metabolic risks. These findings establish SIOs as a superior model for studying nutrient absorption and toxicological effects, emphasizing the need for optimized formula processing techniques and further clinical validation. CI - (c) 2026. The Author(s). FAU - Wang, Xianli AU - Wang X AD - School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhang, Wenchuan AU - Zhang W AD - School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Yang, Shangzhi AU - Yang S AD - School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Zheng, Chengdong AU - Zheng C AD - Heilongjiang Feihe Dairy Co. Ltd., Chaoyang, Beijing, China. FAU - Wang, Zening AU - Wang Z AD - Institutes of Biomedical Sciences, Fudan University, Shanghai, China. FAU - Yang, Guitao AU - Yang G AD - Department of Neurosurgery, Huashan Hospital, Fudan University, Shanghai, China. AD - Institute of Neurosurgery, Fudan University, Shanghai, China. AD - Shanghai Key Laboratory of Brain Function Restoration and Neural Regeneration, Shanghai, China. FAU - Huang, Chenxuan AU - Huang C AD - School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Yao, Haiyang AU - Yao H AD - School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Huang, Kainan AU - Huang K AD - College of Agriculture and Life Sciences, Cornell University, Ithaca, NY, USA. FAU - Yan, Yuanyuan AU - Yan Y AD - School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Jiang, Shilong AU - Jiang S AD - Heilongjiang Feihe Dairy Co. Ltd., Chaoyang, Beijing, China. FAU - Sun, Jianguo AU - Sun J AD - Heilongjiang Feihe Dairy Co. Ltd., Chaoyang, Beijing, China. FAU - Xie, Qinggang AU - Xie Q AD - Heilongjiang Feihe Dairy Co. Ltd., Chaoyang, Beijing, China. FAU - Zhang, Yongjiu AU - Zhang Y AD - Heilongjiang Feihe Dairy Co. Ltd., Chaoyang, Beijing, China. zhangyongjiu@feihe.com. FAU - Li, Xiaoguang AU - Li X AD - State Key Laboratory of Systems Medicine for Cancer, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. lixg@shsmu.edu.cn. FAU - Wang, Hui AU - Wang H AD - State Key Laboratory of Systems Medicine for Cancer, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, China. huiwang@shsmu.edu.cn. LA - eng GR - 82030099/National Natural Science Foundation of China/ GR - 2022YFD2101500/National Key Research and Development Program of China/ GR - GWVI-11.1-43/Shanghai Public Health System Construction Three-Year Action Plan/ GR - 22DZ2303000/the Science and Technology Commission of Shanghai Municipality/ PT - Journal Article DEP - 20260225 PL - England TA - NPJ Sci Food JT - NPJ science of food JID - 101739627 PMC - PMC13013960 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/02/26 15:25 MHDA- 2026/02/26 15:26 PMCR- 2026/02/25 CRDT- 2026/02/25 23:16 PHST- 2025/07/12 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/02/26 15:26 [medline] PHST- 2026/02/26 15:25 [pubmed] PHST- 2026/02/25 23:16 [entrez] PHST- 2026/02/25 00:00 [pmc-release] AID - 10.1038/s41538-025-00672-9 [pii] AID - 672 [pii] AID - 10.1038/s41538-025-00672-9 [doi] PST - epublish SO - NPJ Sci Food. 2026 Feb 25;10(1):101. doi: 10.1038/s41538-025-00672-9. PMID- 41741364 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260826 IS - 1475-2662 (Electronic) IS - 0007-1145 (Print) IS - 0007-1145 (Linking) VI - 135 IP - 12 DP - 2026 Jun 28 TI - Anxiety-metabolism networks in human anorexia nervosa: Responses to caloric and non-caloric meals in the Networks Integrating Anxiety and Metabolism in Anorexia Nervosa (NAMA) randomized trial. PG - 1373-1383 LID - 10.1017/S0007114526106448 [doi] AB - Anorexia nervosa (AN) is an eating disorder that is mediated by psychological and metabolic factors, yet it is unclear how these factors interact. The NAMA trial objective is to clarify the metabo-psychiatric interaction and identify how it affects AN patients' behaviour. This randomised trial will recruit thirty-six treatment-naive female AN patients, 13-18 years of age, and thirty-six matched healthy controls. Participants will undergo psychiatric assessments followed by 12-h overnight fasting. The next morning, baseline assessments of outcomes will be performed. Patients will be randomly allocated 1:1 to receive a mixture with calories or receive a mixture without calories. Healthy controls will also be allocated to receive mixtures with/without calories. Mixtures will be standardised for taste and appearance, and allocation will be masked. The primary outcome measure is resting-state functional MRI 60 min post-consumption of the mixture. Secondary outcomes include (1) blood samples to study markers reflecting metabolic states, hunger/satiety and stress responses, (2) psychometric evaluations of subjective experiences and (3) assessment, in a second meal 3 h later, of the effects of previous calorie intake on subsequent food consumption. This article describes the study protocol, including the analysis plan, for a randomised controlled trial to comprehensively evaluate the effects of calorie intake in AN. The trial will distinguish psychological and metabolic neuronal networks associated with food intake and uncover how their integration affects food intake and other hallmark symptoms in AN. The aim is to accelerate treatment development by identifying brain mechanisms that drive AN. FAU - Ekback, Erik AU - Ekback E AUID- ORCID: 0000-0003-0496-7158 AD - Department of Clinical Sciences, Umea University, Umea, Sweden. ROR: https://ror.org/05kb8h459 AD - Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden. AD - Wallenberg Centre for Molecular Medicine, Umea University, Umea, Sweden. ROR: https://ror.org/05kb8h459 FAU - Yalcin, Lal AU - Yalcin L AD - Department of Psychiatry, Ege University, Izmir, Turkey. FAU - Ozalay, Ozgun AU - Ozalay O AD - Munroe-Meyer Institute, University of Nebraska Medical Center, Omaha, USA. FAU - Granasen, Gabriel AU - Granasen G AD - Department of Public Health and Clinical Medicine, Umea University, Umea, Sweden. FAU - Ozbaran, Burcu AU - Ozbaran B AD - Department of Child and Adolescent Psychiatry, Ege University, Izmir, Turkey. FAU - Gonul, Ali Saffet AU - Gonul AS AD - Department of Psychiatry, Ege University, Izmir, Turkey. FAU - Lagerlof, Olof AU - Lagerlof O AD - Department of Clinical Sciences, Umea University, Umea, Sweden. ROR: https://ror.org/05kb8h459 AD - Wallenberg Centre for Molecular Medicine, Umea University, Umea, Sweden. ROR: https://ror.org/05kb8h459 AD - Department of Medical Translational Biology, Umea University, Umea, Sweden. ROR: https://ror.org/05kb8h459 LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260226 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM MH - Humans MH - *Anorexia Nervosa/psychology/metabolism MH - Female MH - Adolescent MH - *Energy Intake MH - *Anxiety/metabolism/psychology MH - Meals MH - Magnetic Resonance Imaging MH - Hunger PMC - PMC13423519 OTO - NOTNLM OT - Anorexia nervosa OT - Food intake OT - MRI OT - Randomised controlled trial OT - Study protocol EDAT- 2026/02/26 15:23 MHDA- 2026/07/29 18:38 PMCR- 2026/07/30 CRDT- 2026/02/25 22:42 PHST- 2026/07/29 18:38 [medline] PHST- 2026/02/26 15:23 [pubmed] PHST- 2026/02/25 22:42 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - S0007114526106448 [pii] AID - 10.1017/S0007114526106448 [doi] PST - ppublish SO - Br J Nutr. 2026 Jun 28;135(12):1373-1383. doi: 10.1017/S0007114526106448. Epub 2026 Feb 26. PMID- 41741096 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260912 IS - 1878-1888 (Electronic) IS - 0005-7894 (Print) IS - 0005-7894 (Linking) VI - 57 IP - 2 DP - 2026 Mar TI - Low-Burden Detection of Clinical Worsening in Body Dysmorphic Disorder Using Smartphone Sensor and Demographic Data. PG - 220-233 LID - S0005-7894(25)00092-9 [pii] LID - 10.1016/j.beth.2025.09.001 [doi] AB - Body dysmorphic disorder (BDD) is characterized by distressing preoccupations with perceived appearance flaws, leading to functional impairment and suicidal ideation (SI). Traditional approaches for monitoring clinical deterioration in BDD include self-reports and clinician assessments, which can miss acute changes in risk due to infrequent administration and recall biases. Alternatively, real-time monitoring via smartphones and wearable devices can enable low-burden early detection of deterioration, identifying intervention opportunities before someone's condition critically worsens. This study tests the feasibility of using smartphone sensor and demographic data to predict daily clinical acuity. Eighty-two participants with BDD completed ecological momentary assessments (EMA) over 28 days, reporting levels of SI, BDD-related avoidance, and time spent on BDD-related concerns. Smartphone sensor data were collected for 3 months that overlapped with EMA. Machine learning models were trained to predict same-day levels of SI, avoidance, and time spent on BDD using the Global Positioning System (GPS), accelerometer, and demographic data. We evaluated model performance using mean absolute error, Pearson and Spearman correlations, and permutation tests. Random forest (RF) models using time and random split validation outperformed dummy regressor models across outcomes (maximum SI, mean SI, maximum avoidance, mean avoidance, time spent on BDD-related behaviors). Pearson correlations for RF models showed strong predictive performance for BDD-related time (r = .74-.75) and mean and max SI (r = .70-.73). Mean and max avoidance was moderately well predicted (r = .56-.62). Step count and demographic factors (e.g., education, living situation) were the most consistent and important features. This study provides initial evidence that smartphone sensor and demographic data can be used to monitor real-time clinical worsening in BDD, without burdening the patient. This work has potential for building just-in-time interventions that are delivered as deterioration onsets, to prevent its escalation. Future research should test these models in real-world datasets collected over longer periods and subsequently explore integration into interventions and clinical decision making. Trial Registration: ClinicalTrials.gov Identifier: NCT04254575. CI - Copyright (c) 2025 Association for Behavioral and Cognitive Therapies. Published by Elsevier Ltd. All rights reserved. FAU - Weingarden, Hilary AU - Weingarden H AD - Massachusetts General Hospital and Harvard Medical School. Electronic address: hilaryweingarden@gmail.com. FAU - Holstein, Vincent AU - Holstein V AD - Massachusetts General Hospital and Harvard Medical School. FAU - Jonathan, Geneva K AU - Jonathan GK AD - Massachusetts General Hospital and Harvard Medical School. FAU - Armey, Michael AU - Armey M AD - Butler Hospital and Alpert Medical School of Brown University. FAU - Onnela, Jukka-Pekka AU - Onnela JP AD - Harvard T. H. Chan School of Public Health. FAU - Wilhelm, Sabine AU - Wilhelm S AD - Massachusetts General Hospital and Harvard Medical School. LA - eng SI - ClinicalTrials.gov/NCT04254575 GR - K23 MH119372/MH/NIMH NIH HHS/United States PT - Journal Article PT - Observational Study DEP - 20250911 PL - England TA - Behav Ther JT - Behavior therapy JID - 1251640 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Body Dysmorphic Disorders/diagnosis/psychology MH - Ecological Momentary Assessment MH - Machine Learning MH - *Smartphone MH - Suicidal Ideation PMC - PMC12946665 MID - NIHMS2110672 OTO - NOTNLM OT - body dysmorphic disorder OT - clinical deterioration OT - digital phenotyping OT - ecological momentary assessment OT - suicidal ideation COIS- Hilary Weingarden received research support from the National Institute of Mental Health (NIMH; K23MH119372) to conduct this project. Dr. Weingarden receives salary from HabitAware, Inc., has current or prior paid consulting or scientific advisory agreements with Hello Therapeutics, Inc. Augmend Health, and APA Labs, and has received research support from Koa Health, Inc. Dr. Wilhelm is a presenter for the Massachusetts General Hospital Psychiatry Academy in educational programs supported through independent medical education grants from pharmaceutical companies; she has received royalties from Elsevier Publications, Guilford Publications, New Harbinger Publications, Springer, and Oxford University Press. She has received speaking honoraria from various academic institutions and foundations, including the International Obsessive Compulsive Disorder Foundation, the Tourette Association of America and the Centers for Disease Control and Prevention. In addition, she received payment from the Association for Behavioral and Cognitive Therapies for her role as Associate Editor for the Behavior Therapy journal, as well as from John Wiley & Sons, Inc. for her role as Associate Editor on the journal Depression & Anxiety. Dr. Wilhelm has also received honoraria from One-Mind for her role in PsyberGuide Scientific Advisory Board. Dr. Wilhelm is also on the Scientific Advisory Board for Koa Health, Inc. Jimini Health and for Noom, Inc. Dr. Wilhelm has received research and salary support from Koa Health, Inc. Michael Armey is a compensated member of Ilumivu's scientific advisory board and could potentially benefit from the results of this research. Drs. Holstein, Onnela, and Jonathan: None declared. EDAT- 2026/02/26 15:23 MHDA- 2026/03/06 09:08 PMCR- 2026/09/11 CRDT- 2026/02/25 20:56 PHST- 2025/05/12 00:00 [received] PHST- 2025/07/22 00:00 [revised] PHST- 2025/09/08 00:00 [accepted] PHST- 2026/03/06 09:08 [medline] PHST- 2026/02/26 15:23 [pubmed] PHST- 2026/02/25 20:56 [entrez] PHST- 2026/09/11 00:00 [pmc-release] AID - S0005-7894(25)00092-9 [pii] AID - 10.1016/j.beth.2025.09.001 [doi] PST - ppublish SO - Behav Ther. 2026 Mar;57(2):220-233. doi: 10.1016/j.beth.2025.09.001. Epub 2025 Sep 11. PMID- 41739288 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20261009 IS - 1534-3170 (Electronic) IS - 1523-3782 (Linking) VI - 28 IP - 1 DP - 2026 Feb 25 TI - Improving National Fitness: An Updated Review on Cardiovascular Disease Risk Screening and Exercise Training in School-Aged Children in the U.S. LID - 28 [pii] LID - 10.1007/s11886-026-02348-6 [doi] AB - PURPOSE OF REVIEW: To synthesize contemporary evidence on school-feasible cardiovascular disease (CVD) risk screening and exercise training (ET) for U.S. children (ages 6-17) and to outline a pragmatic national framework that prioritizes fitness over size-based metrics. RECENT FINDINGS: Anthropometric indicators such as body mass index (BMI), waist circumference (WC), and waist-to-height ratio (WHtR) remain practical, low-cost tools for identifying obesity-related cardiometabolic risk in schools. When complemented by blood pressure (BP) measurement, they provide a more complete profile. However, all anthropometric and hemodynamic measures are inferior to cardiorespiratory fitness (CRF), which more strongly predicts future CVD risk and all-cause mortality. Both aerobic ET (aET) and resistance ET (rET) independently enhance CRF and muscular strength (MusS), yielding additive cardiometabolic benefits independent of weight loss. Implementation remains limited by reduced physical education (PE) time (PET), fragmented data systems, and insufficient teacher training. A unified national framework emphasizing CRF as a clinical vital sign, standardized screening, and structured ET in schools offers a low-cost, high-impact strategy to curb pediatric CVD risk. Policy efforts should promote validated field tests, teacher training, and integration with pediatric care networks. Shifting the focus from weight reduction to fitness optimization after establishing proper technique reduces stigma, boosts participation, and fosters lifelong physical literacy. Embedding evidence-based screening and ET into educational infrastructure could redefine preventive cardiology, positioning schools as a foundation of cardiovascular health promotion. FAU - Mendoza, Michael F AU - Mendoza MF AD - Ochsner Cancer Institute, The Gayle and Tom Benson Cancer Center, New Orleans, LA, 70121, USA. michael.mendoza@ochsner.org. AD - Faculty of Medicine and Surgery, University of Santo Tomas, Metro Manila, Philippines. michael.mendoza@ochsner.org. AD - Department of Cardiovascular Diseases, Ochsner Clinical School, John Ochsner Heart and Vascular Institute, The University of Queensland School of Medicine, New Orleans, LA, USA. michael.mendoza@ochsner.org. FAU - Anzelmo, Michael A AU - Anzelmo MA AD - Department of Internal Medicine, Ochsner Clinic Foundation, New Orleans, LA, USA. FAU - Suan, Nina M AU - Suan NM AD - Faculty of Medicine and Surgery, University of Santo Tomas, Metro Manila, Philippines. FAU - Fourchy, Marie-Claire AU - Fourchy MC AD - Independent Researcher, New Orleans, LA, USA. FAU - Lavie, Carl J AU - Lavie CJ AD - Department of Cardiovascular Diseases, Ochsner Clinical School, John Ochsner Heart and Vascular Institute, The University of Queensland School of Medicine, New Orleans, LA, USA. LA - eng PT - Journal Article PT - Review DEP - 20260225 PL - United States TA - Curr Cardiol Rep JT - Current cardiology reports JID - 100888969 SB - IM MH - Humans MH - Child MH - *Cardiovascular Diseases/prevention & control MH - United States/epidemiology MH - *Cardiorespiratory Fitness MH - *Mass Screening/methods MH - *Physical Fitness MH - *Exercise MH - Heart Disease Risk Factors MH - Adolescent MH - *Physical Education and Training MH - Risk Assessment MH - Body Mass Index MH - School Health Services MH - Health Promotion MH - Risk Factors OTO - NOTNLM OT - Cardiorespiratory fitness OT - Cardiovascular disease OT - Exercise training OT - Obesity OT - School OT - Screening COIS- Declarations. Human and Animal Rights and Informed Consent: No studies involving human participants or animals were conducted by the authors for this review article. All data discussed are derived from previously published studies that complied with recognized ethical standards. Competing Interests: Dr. Lavie reports being on a data and safety monitoring board for Novo Nordisk for their REDEFINE 3 Trial with CagriSema (but in adults). The other authors declare that they have no conflicts of interest to disclose. EDAT- 2026/02/25 13:37 MHDA- 2026/06/28 13:04 CRDT- 2026/02/25 11:21 PHST- 2026/01/13 00:00 [received] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/06/28 13:04 [medline] PHST- 2026/02/25 13:37 [pubmed] PHST- 2026/02/25 11:21 [entrez] AID - 10.1007/s11886-026-02348-6 [pii] AID - 10.1007/s11886-026-02348-6 [doi] PST - epublish SO - Curr Cardiol Rep. 2026 Feb 25;28(1):28. doi: 10.1007/s11886-026-02348-6. PMID- 41738735 OWN - NLM STAT- MEDLINE DCOM- 20260616 LR - 20260616 IS - 1699-5198 (Electronic) IS - 0212-1611 (Linking) VI - 43 IP - 3 DP - 2026 Jun 16 TI - Psychometric properties of the Feeding Practices and Structure Questionnaire for Infants under 6 months of age in Mexican mothers. PG - 520-529 LID - 10.20960/nh.06128 [doi] AB - Introduction: early infant feeding practices play a crucial role in shaping long-term dietary behaviors and health outcomes. However, validated instruments to assess these practices in infants under six months are scarce, particularly in low -and middle- income countries. The Feeding Practices and Structure Questionnaire for Infants - Milk Feeding version (FPSQ-M) was originally developed in Australia, but its applicability in diverse cultural contexts requires validation. Objective: to translate, culturally adapt, and validate the FPSQ-M for use among Mexican mothers with infants under six months of age. Methods: this cross-sectional study involved 197 Mexican mothers. The FPSQ-M underwent translation, cultural adaptation, and psychometric validation. Construct validity was evaluated through Exploratory Factor Analysis (EFA) and Confirmatory Factor Analysis (CFA). Internal consistency was assessed using Cronbach's alpha, and measurement invariance by maternal education level was tested using multigroup analysis. Results: the EFA identified a four-factor structure, explaining 56.49 % of the variance, aligning with the original FPSQ-M. CFA, after removing two low-loading items, showed improved model fit (GFI = 0.901, CFI = 0.916, RMSEA = 0.063). Measurement invariance confirmed that the FPSQ-M is equivalent across maternal educational groups. Internal consistency was acceptable across all dimensions. Conclusions: the FPSQ-M demonstrated strong psychometric properties in this Mexican sample, making it a reliable tool for assessing feeding practices. Its use is recommended in future research and public health interventions aimed at promoting responsive feeding and preventing early childhood obesity. FAU - Cardenas Villarreal, Velia Margarita AU - Cardenas Villarreal VM AD - School of Nursing. Universidad Autonoma de Nuevo Leon. FAU - Mayo Abarca, Jorge Alberto AU - Mayo Abarca JA AD - School of Nursing and Obstetrics. Universidad de la Salud del Estado de Puebla. FAU - Ortiz Rodriguez, Jeyle AU - Ortiz Rodriguez J AD - School of Public Accounting and Administration. Universidad Autonoma de Nuevo Leon. FAU - Martinez Figueroa, Gabriela Iveth AU - Martinez Figueroa GI AD - School of Public Accounting and Administration. Universidad Autonoma de Nuevo Leon. FAU - Camarillo Cardenas, Karen Paola AU - Camarillo Cardenas KP AD - Independent Researcher. FAU - Hernandez Martinez, Nora AU - Hernandez Martinez N AD - School of Nursing. Universidad Autonoma de Nuevo Leon. LA - eng PT - Journal Article TT - Propiedades psicometricas del Cuestionario de Practicas y Estructura de Alimentacion de Lactantes menores de 6 meses en madres mexicanas. PL - Spain TA - Nutr Hosp JT - Nutricion hospitalaria JID - 9100365 SB - IM MH - Humans MH - Female MH - Mexico MH - Infant MH - Psychometrics MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - *Feeding Behavior MH - *Mothers/psychology MH - Adult MH - Reproducibility of Results MH - Factor Analysis, Statistical MH - Young Adult OTO - NOTNLM OT - Practicas de alimentacion. Validacion psicometrica. Comportamiento alimentario de los padres. Cuestionarios y encuestas. Obesidad infantil. Lactantes. EDAT- 2026/02/25 13:35 MHDA- 2026/06/16 13:32 CRDT- 2026/02/25 08:53 PHST- 2026/06/16 13:32 [medline] PHST- 2026/02/25 13:35 [pubmed] PHST- 2026/02/25 08:53 [entrez] AID - 10.20960/nh.06128 [doi] PST - ppublish SO - Nutr Hosp. 2026 Jun 16;43(3):520-529. doi: 10.20960/nh.06128. PMID- 41737649 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260225 LR - 20260813 IS - 1178-7007 (Print) IS - 1178-7007 (Electronic) IS - 1178-7007 (Linking) VI - 19 DP - 2026 TI - Causal Risk Factors for Type 1 Diabetes in Mendelian Randomization Studies: A Systematic Review and Meta-Analysis. PG - 568784 LID - 10.2147/DMSO.S568784 [doi] LID - 568784 AB - BACKGROUND: Type 1 diabetes mellitus (T1DM) is a chronic disease mediated by autoimmunity, with complex and not fully elucidated pathogenesis. Mendelian randomization (MR) utilizes genetic instrumental variables to minimize confounding and reverse causation; however, individual MR studies are often limited by sample size and result heterogeneity. METHODS: Following PRISMA 2020 guidelines, we systematically searched PubMed, Web of Science, and other databases from 2014 to 2025, ultimately including 53 MR studies (covering 243 exposures). Random-effects models were used to pool effect sizes. Heterogeneity was quantified by Cochran's Q test and I(2) statistic. Bias was further controlled using Egger's regression and leave-one-out sensitivity analysis. RESULTS: This study integrated 53 MR studies (243 exposures) and identified key causal factors for T1DM.IL2RA (OR = 0.22, 95% CI: 0.17-0.27) and TYK2 (OR = 0.61, 95% CI: 0.54-0.69) showed significant protective effects, while IL6R (OR = 1.98, 95% CI: 1.48-2.65) was associated with increased risk. For metabolites, 3-phenylpropionic acid (OR = 0.90, 95% CI: 0.85-0.96) and cinnamoylglycine (OR = 0.89, 95% CI: 0.84-0.96) were protective, while trimethylamine N-oxide (TMAO; OR = 1.11, 95% CI: 1.02-1.20) increased risk. Among gut microbiota, Prevotella 9 (OR = 1.18, 95% CI: 1.08-1.30) was positively associated with risk, whereas Bifidobacterium (OR = 0.82, 95% CI: 0.71-0.95) showed a protective effect. Childhood obesity (OR = 1.32, 95% CI: 1.06-1.64) was also associated with increased T1DM risk. Overall heterogeneity was high (I(2) = 78.3%). CONCLUSION: This study systematically mapped the multi-omics causal risk landscape of T1DM, providing important evidence for precision prevention and targeted intervention. These findings suggest that targeting immune pathways (particularly IL2RA and TYK2) and modulating gut microbiota composition may represent promising strategies for T1DM prevention. Future research should emphasize cross-ethnic validation and life-stage-specific intervention strategies. CI - (c) 2026 Li et al. FAU - Li, Mali AU - Li M AD - Department of Endocrinology, Genetics and Metabolism, Xi'an Children's Hospital, Xi'an, Shaanxi Province, 710003, People's Republic of China. AD - Department of Endocrinology, Genetics and Metabolism, Children's Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710003, People's Republic of China. FAU - Shen, Panting AU - Shen P AD - Department of Endocrinology, Genetics and Metabolism, Xi'an Children's Hospital, Xi'an, Shaanxi Province, 710003, People's Republic of China. AD - Department of Endocrinology, Genetics and Metabolism, Children's Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710003, People's Republic of China. FAU - Liu, Chao AU - Liu C AD - Department of Endocrinology, Genetics and Metabolism, Xi'an Children's Hospital, Xi'an, Shaanxi Province, 710003, People's Republic of China. AD - Department of Endocrinology, Genetics and Metabolism, Children's Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710003, People's Republic of China. FAU - Li, Jia AU - Li J AD - Department of Endocrinology, Genetics and Metabolism, Xi'an Children's Hospital, Xi'an, Shaanxi Province, 710003, People's Republic of China. AD - Department of Endocrinology, Genetics and Metabolism, Children's Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710003, People's Republic of China. FAU - Qiu, Shichao AU - Qiu S AD - Department of Endocrinology, Genetics and Metabolism, Xi'an Children's Hospital, Xi'an, Shaanxi Province, 710003, People's Republic of China. AD - Department of Endocrinology, Genetics and Metabolism, Children's Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710003, People's Republic of China. FAU - Wang, Zhihua AU - Wang Z AUID- ORCID: 0009-0004-6655-6607 AD - Department of Endocrinology, Genetics and Metabolism, Xi'an Children's Hospital, Xi'an, Shaanxi Province, 710003, People's Republic of China. AD - Department of Endocrinology, Genetics and Metabolism, Children's Hospital Affiliated to Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710003, People's Republic of China. LA - eng PT - Journal Article PT - Review DEP - 20260219 PL - New Zealand TA - Diabetes Metab Syndr Obes JT - Diabetes, metabolic syndrome and obesity : targets and therapy JID - 101515585 PMC - PMC12927793 OTO - NOTNLM OT - Mendelian randomization OT - causal risk factors OT - meta-analysis OT - multi-omics OT - type 1 diabetes mellitus COIS- The authors declare no conflicts of interest. EDAT- 2026/02/25 10:20 MHDA- 2026/02/25 10:21 PMCR- 2026/02/19 CRDT- 2026/02/25 04:52 PHST- 2025/09/25 00:00 [received] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/02/25 10:21 [medline] PHST- 2026/02/25 10:20 [pubmed] PHST- 2026/02/25 04:52 [entrez] PHST- 2026/02/19 00:00 [pmc-release] AID - 568784 [pii] AID - 10.2147/DMSO.S568784 [doi] PST - epublish SO - Diabetes Metab Syndr Obes. 2026 Feb 19;19:568784. doi: 10.2147/DMSO.S568784. eCollection 2026. PMID- 41737351 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260813 IS - 2048-6790 (Electronic) IS - 2048-6790 (Linking) VI - 15 DP - 2026 TI - Development and validation of an educational comic book on healthy eating in early childhood. PG - e14 LID - 10.1017/jns.2025.10072 [doi] LID - e14 AB - The objective of this study was to develop and validate an educational comic book designed to promote healthy eating among caregivers of young children. The study was conducted in four phases: (1) literature review and script development; (2) creation of the initial version of the comic book, including illustrations, layout and design, and calculation of the Flesch Readability Index (FI); (3) expert validation of the initial version and calculation of the Content Validity Index (CVI); and (4) adaptation of the comic book based on expert suggestions, recalculation of the FI, and pilot testing (CVI) with a lay population. A total of 64 volunteers participated in the validation process, including 14 expert judges and 50 caregivers responsible for feeding children aged 0 to 5 years. Statistical analysis included descriptive measures and inferential testing using the Wilcoxon signed-rank test. The FI score for the initial version was 85.0%, indicating a reading level classified as "easy to understand." After expert evaluation, the CVI reached 94%, reflecting high agreement among participants. In the revised version, the FI remained high at 84.7%, reinforcing the "easy to understand" reading level, while the CVI increased to 98% following the pilot test, demonstrating strong consensus among participants. A significant improvement in knowledge regarding healthy eating was observed after reading the comic book (p < 0.05). The comic book was validated for appearance, content and readability, showing a positive impact on caregivers' knowledge about healthy eating practices. It represents an accessible and effective resource that can be integrated into community-based nutrition education programmes. CI - (c) The Author(s) 2026. FAU - Soares, Cristiano Carvalho AU - Soares CC AD - Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. ROR: https://ror.org/03m1j9m44 AD - Universidade Federal de Lavras (UFLA), Lavras, MG, Brazil. FAU - Zanin, Luciane AU - Zanin L AD - Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. ROR: https://ror.org/03m1j9m44 FAU - Sperandio, Marcelo AU - Sperandio M AD - Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. ROR: https://ror.org/03m1j9m44 FAU - Florio, Flavia Martao AU - Florio FM AUID- ORCID: 0000-0001-7742-0255 AD - Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. ROR: https://ror.org/03m1j9m44 LA - eng PT - Journal Article PT - Validation Study DEP - 20260205 PL - England TA - J Nutr Sci JT - Journal of nutritional science JID - 101590587 SB - IM MH - Humans MH - Child, Preschool MH - Infant MH - *Diet, Healthy MH - *Comic Books as Topic MH - Female MH - *Health Promotion/methods MH - Comprehension MH - Male MH - *Health Education/methods MH - Caregivers/education MH - Health Knowledge, Attitudes, Practice MH - Reproducibility of Results MH - Pilot Projects PMC - PMC12926666 OTO - NOTNLM OT - Child OT - Comic book OT - Food and nutrition education OT - Food and nutritional health promotion OT - Health education OT - Preschool OT - Validation study COIS- The authors declare that they have no conflicts of interest. EDAT- 2026/02/25 10:21 MHDA- 2026/02/25 10:22 PMCR- 2026/02/05 CRDT- 2026/02/25 04:49 PHST- 2025/04/25 00:00 [received] PHST- 2025/11/13 00:00 [revised] PHST- 2025/12/18 00:00 [accepted] PHST- 2026/02/25 10:22 [medline] PHST- 2026/02/25 10:21 [pubmed] PHST- 2026/02/25 04:49 [entrez] PHST- 2026/02/05 00:00 [pmc-release] AID - S2048679025100724 [pii] AID - 10.1017/jns.2025.10072 [doi] PST - epublish SO - J Nutr Sci. 2026 Feb 5;15:e14. doi: 10.1017/jns.2025.10072. eCollection 2026. PMID- 41737241 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260225 LR - 20260813 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 14 DP - 2026 TI - Psychological outcomes and discharge readiness of parents of preterm infants in China after family integrated care. PG - 1653759 LID - 10.3389/fped.2026.1653759 [doi] LID - 1653759 AB - OBJECTIVE: This study aimed to evaluate the effects of Family Integrated Care (FICare) on the psychological outcomes and discharge readiness of parents of premature infants in the neonatal intensive care unit (NICU). METHODS: This prospective, non-randomized controlled study was conducted in the NICU of Nantong First People's Hospital (China). Parental psychological outcomes (trauma, depression, anxiety, and stress) were assessed using the Trauma Screening Questionnaire (TSQ), post-traumatic stress disorder (PTSD) Checklist for DSM-5 (PCL-5), and the Depression Anxiety Stress Scales (DASS-21) at two timepoints: within two weeks postpartum and at three months after discharge. Discharge readiness was evaluated using validated maternal and paternal readiness scales. Infant clinical outcomes, including nutritional and respiratory milestones, were also recorded. Statistical analysis was conducted using SPSS 23.0 software, and statistical significance was set at p < 0.05. RESULTS: A total of 84 families with preterm infants born at 28-34 weeks of gestation were enrolled and allocated into either the FICare group (n = 42) or the standard care group (n = 42). Baseline demographic and clinical characteristics were comparable between the two groups. FICare significantly improved discharge readiness in both mothers and fathers at NICU discharge (p < 0.001 for all subscales). Parental psychological outcomes in the FICare group showed significant improvements at three months after discharge, including reduced rates of clinically significant trauma (TSQ-positive: mothers 2.38% vs. 21.43%, fathers 4.76% vs. 26.19%; all p < 0.05) and PTSD (PCL-5-positive: mothers 2.38% vs. 23.81%, fathers 2.38% vs. 19.05%), along with decreased symptoms of anxiety, depression, and stress (all p < 0.05). In terms of infant outcomes, the FICare group exhibited earlier initiation of enteral feeding (2.14 +/- 0.95 vs. 3.45 +/- 0.94 days, p < 0.001), quicker achievement of full enteral feeding (15.81 +/- 4.62 vs. 20.45 +/- 3.70 days, p < 0.001), and higher discharge weight (2,202.07 +/- 167.40 g vs. 1,982.94 +/- 176.31 g, p < 0.001), all without prolonging NICU stay or respiratory support. CONCLUSION: FICare significantly enhanced the psychological well-being and discharge preparedness of parents of preterm infants, while also promoting improved nutritional outcomes in neonates. CI - (c) 2026 Zhu, Jiang, Hong, Song and Yang. FAU - Zhu, Yuanyuan AU - Zhu Y AD - Department of Neonatology, Nantong First People's Hospital, Nantong, Jiangsu, China. FAU - Jiang, Yaqiong AU - Jiang Y AD - Department of Neonatology, Nantong First People's Hospital, Nantong, Jiangsu, China. FAU - Hong, Fei AU - Hong F AD - Department of Neonatology, Nantong First People's Hospital, Nantong, Jiangsu, China. FAU - Song, Lei AU - Song L AD - Department of Neonatology, Nantong First People's Hospital, Nantong, Jiangsu, China. FAU - Yang, Xiaohong AU - Yang X AD - Department of Neonatology, Nantong First People's Hospital, Nantong, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260209 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC12926483 OTO - NOTNLM OT - NICU OT - discharge readiness OT - family integrated care OT - parental psychological outcomes OT - premature infants COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/25 10:23 MHDA- 2026/02/25 10:24 PMCR- 2026/02/09 CRDT- 2026/02/25 04:48 PHST- 2025/06/25 00:00 [received] PHST- 2026/01/15 00:00 [revised] PHST- 2026/01/21 00:00 [accepted] PHST- 2026/02/25 10:24 [medline] PHST- 2026/02/25 10:23 [pubmed] PHST- 2026/02/25 04:48 [entrez] PHST- 2026/02/09 00:00 [pmc-release] AID - 10.3389/fped.2026.1653759 [doi] PST - epublish SO - Front Pediatr. 2026 Feb 9;14:1653759. doi: 10.3389/fped.2026.1653759. eCollection 2026. PMID- 41737101 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260225 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 1 DP - 2026 Jan TI - Development of National Diagnostic Reference Levels for Chest Computed Tomography in Georgia. PG - e102125 LID - 10.7759/cureus.102125 [doi] LID - e102125 AB - Computed tomography (CT) is an essential diagnostic modality in modern medicine; however, it is associated with relatively high radiation exposure. Optimizing radiation dose while maintaining diagnostic image quality remains a major priority in clinical practice. Diagnostic reference levels (DRLs) are internationally recommended tools for dose optimization, yet national DRLs for chest CT examinations have not previously been established in Georgia. The objective of this study is to assess radiation dose metrics from non-contrast chest CT examinations across medical institutions in Georgia and to establish preliminary national DRLs for adult and pediatric populations based on real-world clinical practice. A nationwide, multicenter observational study was conducted across 27 Georgian medical institutions. Dose data from 136 consecutive patients who underwent non-contrast chest CT examinations between November 2024 and August 2025 were retrospectively analyzed. Both adult and pediatric patients were included. Radiation dose indicators, including CT Dose Index Volume (CTDIvol) and Dose Length Product (DLP), were collected alongside patient anthropometric parameters. Dose distributions were stratified by body mass index (BMI). DRLs were derived using the 75th percentile methodology in accordance with recommendations from the International Commission on Radiological Protection (ICRP). Substantial inter-facility variability in CT radiation dose metrics was observed, reflecting differences in scanner technology, protocol design, and utilization of automatic exposure control (AEC) systems. BMI-stratified analysis enabled the derivation of realistic, country-specific reference values. The calculated 75th percentile values of CTDIvol and DLP served as the basis for defining preliminary national DRLs for non-contrast chest CT examinations in Georgia. This nationwide assessment demonstrates the feasibility and importance of establishing national DRLs for chest CT in Georgia. The proposed DRLs provide a practical framework for radiation dose optimization without compromising diagnostic quality. Adoption of national DRLs is expected to reduce unnecessary radiation exposure, support continuous quality improvement, and enhance patient safety. Future efforts should focus on periodic DRL updates, broader implementation of dose-optimization technologies, and expansion to additional CT examination types. CI - Copyright (c) 2026, Tortladze et al. FAU - Tortladze, Irakli AU - Tortladze I AD - Radiology, Tbilisi State Medical University, First Medical University Clinic, Tbilisi, GEO. FAU - Urushadze, Otar AU - Urushadze O AD - Clinical Radiology, Tbilisi State Medical University, Tbilisi, GEO. FAU - Nemsadze, Grigol AU - Nemsadze G AD - Radiology, Tbilisi State Medical University, First Medical University Clinic, Tbilisi, GEO. FAU - Esvanjia, Nino AU - Esvanjia N AD - Medical Physics, LEPL Agency of Nuclear and Radiation Safety, Tbilisi, GEO. FAU - Karanadze, Ketevan AU - Karanadze K AD - Radiology, Aleksandre Aladashvili Clinic, Tbilisi, GEO. LA - eng PT - Journal Article DEP - 20260123 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12926703 OTO - NOTNLM OT - alara OT - ct OT - drl OT - georgia national drls OT - radiology COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Tbilisi State Medical University issued approval MES 2 24 0001357357. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/02/25 10:21 MHDA- 2026/02/25 10:22 PMCR- 2026/01/23 CRDT- 2026/02/25 04:47 PHST- 2026/01/23 00:00 [accepted] PHST- 2026/02/25 10:22 [medline] PHST- 2026/02/25 10:21 [pubmed] PHST- 2026/02/25 04:47 [entrez] PHST- 2026/01/23 00:00 [pmc-release] AID - 10.7759/cureus.102125 [doi] PST - epublish SO - Cureus. 2026 Jan 23;18(1):e102125. doi: 10.7759/cureus.102125. eCollection 2026 Jan. PMID- 41736948 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260225 LR - 20260813 IS - 1664-042X (Print) IS - 1664-042X (Electronic) IS - 1664-042X (Linking) VI - 17 DP - 2026 TI - Effects of the modified field test on exercise-induced peripheral fatigue in non-elite badminton players. PG - 1734224 LID - 10.3389/fphys.2026.1734224 [doi] LID - 1734224 AB - OBJECTIVES: This study aimed to examine the effects of a modified badminton field test (FT) on exercise-induced peripheral fatigue and its underlying responses in non-elite male college badminton players. We hypothesized that the repeated high-intensity intermittent efforts during the modified FT would lead to significant reductions in lower-limb muscle performance and elevate markers of peripheral fatigue, including blood lactate accumulation, perceived exertion, and heart rate elevation. METHODS: In a single-arm repeated-measures design, 15 healthy male collegiate badminton players (age: 20.2 +/- 0.9 years; BMI: 20.9 +/- 1.5 kg/m(2); playing experience: 1.3 +/- 0.4 years) performed five consecutive sets of the field test interspersed with 60 s of passive recovery. Each set involved on-court shuttle runs to eight LED targets and was terminated upon volitional exhaustion, achievement of heart rate >/=92% HRmax, or an RPE >/=18 (Borg 6-20 scale). Markers of peripheral fatigue-vertical jump height (VJ), heart rate (HR), rating of perceived exertion (RPE), and fingertip blood lactate (BL)-were assessed before the test and after each set. Data were analyzed using one-way repeated-measures ANOVA (for VJ, HR, RPE) and paired t-tests (for BL). RESULTS: VJ height progressively decreased from 41.8 +/- 4.7 cm at baseline to 25.5 +/- 4.5 cm after set 5 (Delta = 39.9%, eta(2)p = 0.60, large effect size; p < 0.001). Concurrent increases were observed in HR (63.5 +/- 3.8 to 178.0 +/- 3.9 bpm; eta(2)p = 0.96, large effect size), RPE (6-18.7 +/- 0.9; eta(2)p = 0.95, large effect size), and BL (2.82 +/- 1.12 to 16.07 +/- 2.52 mmol L(-1); Cohen's d = 6.8, large effect size; all p < 0.001). These convergent metabolic, neuromuscular, and perceptual responses confirm the induction of pronounced peripheral fatigue. CONCLUSION: A single 15-min modified badminton FT reliably elicits marked peripheral fatigue in non-elite male players. The protocol provides coaches with an ecologically valid, low-cost and high-safety tool to monitor training load and mitigate fatigue-related injury risk. Future research should validate the FT in female and youth cohorts and explore longitudinal applications. CI - Copyright (c) 2026 Huang, Song, Huang, Zeng, Li and Liu. FAU - Huang, Heping AU - Huang H AD - Institute of Physical Education and Sports, Huzhou University, Huzhou, Zhejiang, China. FAU - Song, Jian AU - Song J AD - College of Physical Education and Health, China Pharmaceutical University, Nanjing, Jiangsu, China. FAU - Huang, Huiming AU - Huang H AD - College of Physical Education and Health, China Pharmaceutical University, Nanjing, Jiangsu, China. AD - Faculty of Sports Science, Ningbo University, Ningbo, Zhejiang, China. FAU - Zeng, Yufan AU - Zeng Y AD - Institute of Physical Education and Sports, Huzhou University, Huzhou, Zhejiang, China. FAU - Li, Xingchang AU - Li X AD - Institute of Physical Education, SuQian University, SuQian, Jiangsu, China. FAU - Liu, Su AU - Liu S AD - College of Physical Education and Health, China Pharmaceutical University, Nanjing, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260209 PL - Switzerland TA - Front Physiol JT - Frontiers in physiology JID - 101549006 PMC - PMC12926157 OTO - NOTNLM OT - badminton OT - field test OT - peripheral fatigue OT - training load OT - vertical jump COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/25 10:23 MHDA- 2026/02/25 10:24 PMCR- 2026/02/09 CRDT- 2026/02/25 04:45 PHST- 2025/10/28 00:00 [received] PHST- 2025/12/30 00:00 [revised] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/02/25 10:24 [medline] PHST- 2026/02/25 10:23 [pubmed] PHST- 2026/02/25 04:45 [entrez] PHST- 2026/02/09 00:00 [pmc-release] AID - 1734224 [pii] AID - 10.3389/fphys.2026.1734224 [doi] PST - epublish SO - Front Physiol. 2026 Feb 9;17:1734224. doi: 10.3389/fphys.2026.1734224. eCollection 2026. PMID- 41736762 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260225 LR - 20260813 IS - 1179-1411 (Print) IS - 1179-1411 (Electronic) IS - 1179-1411 (Linking) VI - 18 DP - 2026 TI - Basal Luteinizing Hormone Combined with Age and BMI as a Simplified Screening Model for Central Precocious Puberty in Girls. PG - 583959 LID - 10.2147/IJWH.S583959 [doi] LID - 583959 AB - PURPOSE: The gonadotropin-releasing hormone (GnRH) stimulation test is regarded as the diagnostic gold standard for central precocious puberty (CPP); however, its invasiveness and limited accessibility restrict its routine use in clinical practice. Moreover, reported cutoff values for basal luteinizing hormone (LH) vary across studies, and simple screening models applicable to everyday clinical settings remain limited. This study aimed to evaluate routinely available clinical, biochemical, and imaging indicators and to develop a simplified screening model for early differentiation of CPP from premature thelarche (PT) in girls. PATIENTS AND METHODS: This retrospective study included 429 girls aged 4-8 years presenting with early breast development between January 2019 and January 2023. Basal sex hormone levels, anthropometric parameters, bone age, and pelvic ultrasound findings were collected. Univariable analysis, multivariable logistic regression, and receiver operating characteristic (ROC) curve analysis were performed to assess the screening performance of individual indicators and a combined model. RESULTS: Girls with CPP exhibited significantly higher age, BMI, bone age advancement, basal LH levels, and ovarian volumes than those with PT did (all p<0.05). Multivariable analysis identified age, BMI, and basal LH concentration as independent factors associated with CPP. Among individual indicators, basal LH concentration showed the strongest discriminatory ability (AUC=0.842), with a cutoff value of 0.15 IU/L. A simplified combined model integrating basal LH concentration, age, and BMI further improved screening performance (AUC=0.880). Pelvic ultrasound parameters did not emerge as independent predictors in multivariable analyses. CONCLUSION: A simplified screening model incorporating basal LH concentration, age, and BMI may serve as a practical initial screening tool to identify girls at higher risk of CPP and to reduce unnecessary GnRH stimulation testing. Prospective multicenter studies are required to validate the generalizability of this approach before broader clinical implementation. CI - (c) 2026 Li et al. FAU - Li, Jiayu AU - Li J AD - Department of Child Healthcare, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China. AD - Department of Child Healthcare, Angel Women's and Children's Hospital, Chengdu, People's Republic of China. FAU - Cui, Yali AU - Cui Y AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China. AD - Department of Laboratory Medicine, Sichuan Provincial Children's Hospital (Sichuan Provincial Children's Medical Center), Meishan, People's Republic of China. AD - Department of Laboratory Medicine, Meishan Women and Children's Hospital, Meishan, People's Republic of China. FAU - Shuai, Jiaji AU - Shuai J AD - Department of Child Healthcare, Meishan Women and Children's Hospital, Meishan, People's Republic of China. FAU - Li, Wei AU - Li W AUID- ORCID: 0000-0003-4632-0248 AD - Department of Child Healthcare, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China. FAU - Li, Yingying AU - Li Y AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China. FAU - Yan, Ziyi AU - Yan Z AUID- ORCID: 0000-0003-3298-9311 AD - Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, People's Republic of China. FAU - Yu, Tao AU - Yu T AD - Department of Child Healthcare, West China Second University Hospital, Sichuan University, Chengdu, People's Republic of China. AD - Department of Child Healthcare, Meishan Women and Children's Hospital, Meishan, People's Republic of China. LA - eng PT - Journal Article DEP - 20260216 PL - New Zealand TA - Int J Womens Health JT - International journal of women's health JID - 101531698 PMC - PMC12927745 OTO - NOTNLM OT - basal LH OT - body mass index OT - breast development OT - ovarian volume OT - precocious puberty COIS- The authors report no conflicts of interest in this work. EDAT- 2026/02/25 10:21 MHDA- 2026/02/25 10:22 PMCR- 2026/02/16 CRDT- 2026/02/25 04:43 PHST- 2025/11/24 00:00 [received] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/02/25 10:22 [medline] PHST- 2026/02/25 10:21 [pubmed] PHST- 2026/02/25 04:43 [entrez] PHST- 2026/02/16 00:00 [pmc-release] AID - 583959 [pii] AID - 10.2147/IJWH.S583959 [doi] PST - epublish SO - Int J Womens Health. 2026 Feb 16;18:583959. doi: 10.2147/IJWH.S583959. eCollection 2026. PMID- 41735965 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1472-6920 (Electronic) IS - 1472-6920 (Linking) VI - 26 IP - 1 DP - 2026 Feb 24 TI - A feasibility randomised controlled trial of patient education videos assessing multimedia design effects on engagement and learning in adolescents with scoliosis. LID - 10.1186/s12909-026-08748-0 [doi] LID - 679 AB - Multimedia patient education is increasingly used in healthcare, particularly useful in under-resourced settings. While scientific content is well studied, limited research examines how design influences patient engagement. Scoliosis often lacks adequate resources, and integration of multimedia learning principles in this context remains underexplored.Objectives This triple-masked three-armed feasibility parallel randomised controlled trial (RCT) assessed the viability of examining how evidence-informed design principles affect knowledge, engagement, quality of life, anxiety, and physical activity among Irish community-based adolescents with scoliosis.Methods Forty-six participants aged 10-18 were randomised into usual care (UC), standard video education (TRAD), or videos incorporating multimedia learning principles (AUGM). Videos were delivered weekly online over six weeks. Primary outcomes: feasibility of recruitment, intervention adherence, outcome completion, satisfaction and adverse events. Secondary outcomes: knowledge (quizzes), engagement (YouTube analytics), quality of life (EQ-5D-Y-3 L, SRS-22r), anxiety (STAI-Ch), and physical activity (PAQ-Ch)-were evaluated at baseline, post-intervention and week 8.Results Of 112 respondents, 46 participants (mean age 14.8 +/- 2.0, 86% female) consented and were randomised (UC: n = 16, AUGM: n = 15, TRAD: n = 15). Baseline completion was 93.5%, weekly adherence ranged from 77 to 97% and follow-up completion was 82.6%. No adverse events occurred. 80% were satisfied with the videos. Knowledge improved by 9% (+/- 15%) across all groups and improved more when engagement with the videos was higher (p=0.011). Dropouts in the AUGM group were lower (n = 1) vs. the UC or TRAD groups (n = 3 each).Conclusion This feasibility RCT demonstrated successful recruitment, retention, and outcome completion, supporting a fully powered RCT to evaluate multimedia design principles in scoliosis education.Practice implications Delivering an online educational intervention is feasible and expands reach to rural/remote patients with scoliosis and reduce travel burdens. Online education fosters learning, especially for those who engage more on the first viewing. Using evidence-informed design appears to enhance adherence to and reduce dropouts. FAU - Van Oirschot, Garett AU - Van Oirschot G AD - University College Dublin, Dublin, Ireland. garett.vanoirschot@ucd.ie. AD - Insight Research Ireland Centre for Data Analytics, Dublin, Ireland. garett.vanoirschot@ucd.ie. AD - School of Public Health, Physiotherapy & Sports Science, Health Sciences Centre, University College Dublin, Stillorgan Road, Belfield, Dublin, D4, Ireland. garett.vanoirschot@ucd.ie. FAU - Purcell, Ciaran AU - Purcell C AD - University College Dublin, Dublin, Ireland. AD - Insight Research Ireland Centre for Data Analytics, Dublin, Ireland. AD - University of Limerick, Limerick, Ireland. FAU - Keogh, Alison AU - Keogh A AD - Insight Research Ireland Centre for Data Analytics, Dublin, Ireland. AD - Trinity College Dublin, Dublin, Ireland. FAU - Greene, Ciara M AU - Greene CM AD - University College Dublin, Dublin, Ireland. FAU - Doherty, Cailbhe AU - Doherty C AD - University College Dublin, Dublin, Ireland. AD - Insight Research Ireland Centre for Data Analytics, Dublin, Ireland. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260224 PL - England TA - BMC Med Educ JT - BMC medical education JID - 101088679 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Anxiety MH - Feasibility Studies MH - Health Knowledge, Attitudes, Practice MH - Ireland MH - Multimedia MH - *Patient Education as Topic/methods MH - Patient Participation MH - Patient Satisfaction MH - Quality of Life MH - *Scoliosis/psychology/therapy MH - *Video Recording PMC - PMC13112687 OTO - NOTNLM OT - Health education OT - Multimedia OT - Musculoskeletal OT - Paediatrics OT - Patient education OT - Scoliosis COIS- Declarations. Ethics approval and consent to participate: Ethical approval was granted by the Human Research Ethics Committee of University College Dublin as LS-23-15-VanOirschot-Doherty on 3 May 2023. All procedures were performed in compliance with relevant laws and institutional guidelines. Informed consent was obtained for experimentation with human participants. The privacy rights of human participants was always observed. Consent for publication: All participants granted full consent for these study results to be submitted for publication. Competing interests: The authors declare no competing interests. EDAT- 2026/02/25 00:29 MHDA- 2026/06/27 12:36 PMCR- 2026/02/24 CRDT- 2026/02/24 23:49 PHST- 2025/10/03 00:00 [received] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/06/27 12:36 [medline] PHST- 2026/02/25 00:29 [pubmed] PHST- 2026/02/24 23:49 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - 10.1186/s12909-026-08748-0 [pii] AID - 8748 [pii] AID - 10.1186/s12909-026-08748-0 [doi] PST - epublish SO - BMC Med Educ. 2026 Feb 24;26(1):679. doi: 10.1186/s12909-026-08748-0. PMID- 41735929 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Feb 24 TI - A detailed analysis of the effects of body parameters on motor function and fine motor skills measured at one-year intervals in patients with spinal muscular atrophy. LID - 10.1186/s12887-026-06583-2 [doi] LID - 245 AB - BACKGROUND: Spinal muscular atrophy mainly affects motor neurons in the spinal cord, leading to progressive muscular atrophy and weakness. This study aims to carefully analyse the effect of body parameters on motor function and fine motor skills, measured at one-year intervals, in patients with spinal muscular atrophy. METHODS: The study included 38 participants diagnosed with SMA. Patients were divided into three groups based on their level of motor function: non-sitters (n = 9), sitters (n = 23), and walkers (n = 6). Anthropometric measurements (weight, height/length) were taken in all participants, and BMI and BMI-z-score were calculated. The motor function was assessed using validated scales: CHOP-INTEND for the non-sitters group and HFMSE scale for the sitters and walkers group. The RULM scale assessed fine motor skills for the sitters and walkers group. RESULTS: At the 12-month follow-up, the CHOP-INTEND scale showed improvement in most non-sitter patients (6/9). The sitter's group was more heterogeneous on the HFMSE scale, with 10 out of 23 patients showing deterioration in function, 8 showing improvement, while the walker's group showed the least variability. In the non-sitters group, the dominant category of BMI z-score was underweight, while half of the sitters in the group were underweight, although there were just as many healthy weights. The strongest group, the walkers, was mostly healthy. We have observed a certain tendency that as BMI increases, motor function increases in all groups, while fine motor skill decreases in the most varied sitters group. CONCLUSIONS: As BMI increases in SMA patients, motor function improves. Fine motor skill deteriorates as BMI increases in the sitter's group. The assessment of individual components of motor function and fine motor skills reveals the actual changes that occur over time in patients with SMA. FAU - Gajewska, Ewa AU - Gajewska E AD - Chair and Clinic of the Developmental Neurology, Poznan University of Medical Sciences, Poznan, Poland. ewagajewska1011@gmail.com. FAU - Sobieska, Magdalena AU - Sobieska M AD - Department of Rehabilitation and Physiotherapy,, Poznan University of Medical Sciences, Poznan, Poland. FAU - Bieniaszewska, Aleksandra AU - Bieniaszewska A AD - Chair and Clinic of the Developmental Neurology, Poznan University of Medical Sciences, Poznan, Poland. FAU - Sowinska, Anna AU - Sowinska A AD - Department of Computer Science and Statistics, Poznan University of Medical Sciences, Poznan, Poland. FAU - Michalska, Joanna AU - Michalska J AD - Chair and Clinic of the Developmental Neurology, Poznan University of Medical Sciences, Poznan, Poland. FAU - Steinborn, Barbara AU - Steinborn B AD - Chair and Clinic of the Developmental Neurology, Poznan University of Medical Sciences, Poznan, Poland. LA - eng PT - Journal Article DEP - 20260224 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Female MH - *Motor Skills/physiology MH - Male MH - Body Mass Index MH - Follow-Up Studies MH - Child, Preschool MH - *Spinal Muscular Atrophies of Childhood/physiopathology MH - Child MH - Infant MH - *Muscular Atrophy, Spinal/physiopathology PMC - PMC13037007 OTO - NOTNLM OT - BMI OT - BMI-z-score OT - Motor function OT - SMA OT - Upper limb COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Poznan University of Medical Sciences ethics committee nr 200/23. All parents signed informed consent before patient enrollment. Consent for publication: All authors consent to publication. Competing interests: The authors declare no competing interests. EDAT- 2026/02/25 00:29 MHDA- 2026/06/28 00:37 PMCR- 2026/02/24 CRDT- 2026/02/24 23:48 PHST- 2025/11/14 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/06/28 00:37 [medline] PHST- 2026/02/25 00:29 [pubmed] PHST- 2026/02/24 23:48 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - 10.1186/s12887-026-06583-2 [pii] AID - 6583 [pii] AID - 10.1186/s12887-026-06583-2 [doi] PST - epublish SO - BMC Pediatr. 2026 Feb 24;26(1):245. doi: 10.1186/s12887-026-06583-2. PMID- 41735926 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Feb 24 TI - Determinants and strategies influencing implementation of a clinically integrated breastfeeding peer counseling program: an application of the Implementation Research Logic Model. LID - 10.1186/s12884-026-08851-6 [doi] LID - 356 AB - BACKGROUND: Breastmilk feeding improves long term health outcomes, but few mother-infant dyads in the US meet recommendations, and breastfeeding duration is lowest for racially minoritized populations. Clinically integrated Breastfeeding Peer Counseling (ci-BPC) is an evidence-based practice that has been associated with improved breastfeeding outcomes for minoritized populations, but implementation evidence is limited. Our objective was to systematically evaluate how and why a ci-BPC program worked by identifying how implementation strategies addressed barriers and leveraged facilitators in the implementation setting, and explaining results using Implementation Research Logic Model (IRLM). METHODS: Explanatory mixed methods were utilized to triangulate findings from semi-structured interviews and qualitative document review to identify barriers and facilitators to implementation, as well as strategies used to address barriers and leverage facilitators. Interviews were conducted in 2022-2023 with patients, providers, nurses, and clinical leaders at the tertiary perinatal center and affiliated outpatient clinic where the ci-BPC program was implemented, and analyzed using directed content analysis with the Consolidated Framework for Implementation Research (CFIR) and Expert Recommendations for Implementing Change (ERIC) framework. Documents included publications, meeting minutes, workflows, protocols, correspondences, quality improvement data, electronic medical records, job descriptions, and grant applications from 2015 to 2024. RESULTS: Saturation of themes was achieved with 10 clinical team and 18 patient interviews and qualitative document review. Implementation barriers included patient education needs, insufficient staff capacity to provide breastfeeding care, and lack of continuity between inpatient and outpatient service lines. The ci-BPC model addressed these barriers and achieved implementation outcomes with position criteria that prioritized experience and shared traits with patients that supported acceptability and effectiveness; a multidisciplinary leadership team guiding implementation that aided adoption and feasibility; clinical integration via specialized workflows, EMR access, and ongoing training and communications that supported adoption, fidelity, and feasibility; and a dedicated physical workspace for outpatient counseling that supported feasibility and fidelity. CONCLUSIONS: Use of the IRLM demonstrated how implementation strategies leveraged existing facilitators and overcame barriers at the individual, team, and system level and to achieve program effectiveness and implementation outcomes. These findings can inform future implementation of ci-BPC, and other clinically integrated perinatal community health worker models, with evidence-based strategies for implementation. FAU - Keenan-Devlin, Lauren S AU - Keenan-Devlin LS AD - Department of Obstetrics and Gynecology, Endeavor Health, University of Chicago Pritzker School of Medicine, Evanston, IL, USA. lauren.keenandevlin@endeavorhealth.org. FAU - Borders, Ann E B AU - Borders AEB AD - Department of Obstetrics and Gynecology, Endeavor Health, University of Chicago Pritzker School of Medicine, Northwestern University Center for Healthcare Studies - Institute for Public Health and Medicine, Evanston, IL, USA. FAU - Johnson, Tricia J AU - Johnson TJ AD - Department of Health Systems Management, Rush University, Chicago, IL, USA. FAU - Hirschhorn, Lisa R AU - Hirschhorn LR AD - Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. LA - eng GR - K01 HS027906/HS/AHRQ HHS/United States PT - Journal Article DEP - 20260224 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - *Breast Feeding/psychology MH - *Counseling/methods MH - Female MH - *Peer Group MH - Qualitative Research MH - Implementation Science MH - Infant, Newborn MH - Program Evaluation MH - Adult PMC - PMC13036892 OTO - NOTNLM OT - Breastfeeding peer counseling OT - Clinical integration OT - Disparities OT - Equity OT - Implementation OT - Mixed methods COIS- Declarations. Ethics approval and consent to participate: This research was reviewed and approved by the Endeavor Health Institutional Review Board (EH21-249) and all participants completed informed consent prior to participation. All methods were carried out in accordance with relevant institutional guidelines and regulations. Consent for publication: not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/25 00:29 MHDA- 2026/06/28 16:09 PMCR- 2026/02/24 CRDT- 2026/02/24 23:47 PHST- 2025/07/24 00:00 [received] PHST- 2026/02/18 00:00 [accepted] PHST- 2026/06/28 16:09 [medline] PHST- 2026/02/25 00:29 [pubmed] PHST- 2026/02/24 23:47 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - 10.1186/s12884-026-08851-6 [pii] AID - 8851 [pii] AID - 10.1186/s12884-026-08851-6 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Feb 24;26(1):356. doi: 10.1186/s12884-026-08851-6. PMID- 41735920 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Feb 24 TI - Feasibility of a school-based peer-led high-intensity interval training intervention: the Young Fitness Leaders project. LID - 10.1186/s12889-026-26543-w [doi] LID - 799 AB - INTRODUCTION: While school-based high-intensity interval training (HIIT) has demonstrated efficacy for improving adolescents' physical and mental health, interventions have largely been researcher-led, which limits scalability. This could be resolved via peer-led programmes, whereby older pupils (i.e., peer-leaders) deliver HIIT to younger pupils (i.e., peer-recipients). We aimed to explore the feasibility of a school-based peer-led HIIT intervention. METHODS: Using a non-randomised controlled trial design, 44 Year 7 pupils (aged 12.1 +/- 0.3 years [mean +/- SD]) were recruited from one school in North East England, with 21 (8 girls) allocated as peer-recipients to an 8-week HIIT intervention, and 23 (17 girls) as controls. Five Year 12-13 pupils (aged 17.3 +/- 0.4 years) were recruited as peer-leaders and received training on school-based HIIT based on boxing and whole-body exercises. Peer-leaders then delivered twice weekly HIIT sessions during morning tutor time. Primary outcomes were recruitment, retention, attendance and acceptability (explored in post-intervention focus groups with peer-recipients, peer-leaders and teachers). Secondary outcomes included intervention fidelity (via researcher field note observations and heart rate monitoring), and preliminary impact on physical fitness and psychological outcomes. RESULTS: Recruitment was 72% (21/29 eligible pupils), 74% (23/31) and 42% (5/12) for peer-recipients, controls and peer-leaders, respectively. All control participants completed the study; one peer-leader left the school, and two peer-recipients withdrew (94% overall retention). Intervention attendance (expressed as percentage of scheduled sessions) was 73 +/- 31%. The intervention was generally well-received by peer-recipients, peer-leaders and teachers. The mean peak heart rate across all repetitions was 76% of age-predicted maximal, with a between- and within-participant variability of 6% points and 8% points, respectively. For the physical fitness and psychological outcomes, intervention effect directions were inconsistent and effect estimates imprecise. CONCLUSIONS: Peer-led HIIT may represent a scalable and feasible school-based physical activity model from a recruitment, retention, attendance and acceptability perspective. However, intervention heart rates and session observations suggest HIIT activities were not always delivered and performed as intended, which could limit intervention effectiveness in larger-scale trials. Future iterations of peer-led HIIT programmes should focus on refining intervention delivery by providing an enhanced training and support package for peer-leaders. TRIAL REGISTRATION: The trial was registered on ISRCTN, the UK's Clinical Study Registry on 6th March 2023 ( https://www.isrctn.com/ISRCTN89390191 ). The trial registration number is ISRCTN89390191. FAU - Weston, Kathryn L AU - Weston KL AD - Department of Psychological Sciences and Health, University of Strathclyde, Glasgow, UK. kathryn.weston@strath.ac.uk. AD - School of Applied Sciences, Edinburgh Napier University, Edinburgh, UK. kathryn.weston@strath.ac.uk. FAU - Burn, Naomi L AU - Burn NL AD - Adelaide University Online, Adelaide University, Adelaide, Australia. FAU - Goroski, Alexis AU - Goroski A AD - Human Nutrition and Exercise Research Centre, Newcastle University, Newcastle Upon Tyne, UK. FAU - Weston, Matthew AU - Weston M AD - Institute for Sport, Physical Education and Health Science, Moray House School of Education and Sport, University of Edinburgh, Edinburgh, UK. AD - Institute of Sport, Manchester Metropolitan University, Manchester, UK. FAU - Galna, Brook AU - Galna B AD - School of Allied Health (Exercise Science), Murdoch University, Murdoch, Australia. AD - Centre for Healthy Ageing, Health Futures Institute, Murdoch University, Murdoch, Australia. AD - Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK. FAU - Glossop, Rosie AU - Glossop R AD - Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK. FAU - Patterson, Maddey AU - Patterson M AD - Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK. FAU - Batten, Hannah AU - Batten H AD - Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK. FAU - Gordon, Alfie AU - Gordon A AD - School of Applied Sciences, Edinburgh Napier University, Edinburgh, UK. FAU - Basterfield, Laura AU - Basterfield L AD - Human Nutrition and Exercise Research Centre, Newcastle University, Newcastle Upon Tyne, UK. laura.basterfield@newcastle.ac.uk. AD - Population Health Sciences Institute, Newcastle University, Newcastle Upon Tyne, UK. laura.basterfield@newcastle.ac.uk. LA - eng PT - Controlled Clinical Trial PT - Journal Article DEP - 20260224 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *High-Intensity Interval Training/methods MH - *Peer Group MH - Feasibility Studies MH - Female MH - Adolescent MH - Male MH - England MH - Child MH - Schools MH - Physical Fitness MH - *School Health Services/organization & administration MH - Focus Groups PMC - PMC12961876 OTO - NOTNLM OT - Adolescents OT - Feasibility OT - HIIT OT - High-intensity interval training OT - Peer-leaders OT - Physical activity OT - Schools COIS- Declarations. Ethics approval and consent to participate: Newcastle University's Faculty of Medical Sciences Research Ethics Committee provided ethics approval for the study (ref 2331/22078 and ref 2451/27290). All participants provided written informed consent. For participants under the age of 18, opt-out informed consent from parents was used. Consent for publication: Participants gave written informed consent for their personal data and identifying images to be published in this study. Competing interests: The authors declare no competing interests. EDAT- 2026/02/25 00:29 MHDA- 2026/06/27 16:10 PMCR- 2026/02/24 CRDT- 2026/02/24 23:47 PHST- 2025/09/18 00:00 [received] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/06/27 16:10 [medline] PHST- 2026/02/25 00:29 [pubmed] PHST- 2026/02/24 23:47 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - 10.1186/s12889-026-26543-w [pii] AID - 26543 [pii] AID - 10.1186/s12889-026-26543-w [doi] PST - epublish SO - BMC Public Health. 2026 Feb 24;26(1):799. doi: 10.1186/s12889-026-26543-w. PMID- 41735897 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Feb 24 TI - Is the 3-min walk test a valid alternative to the 6-min walk test in typically developing school children? LID - 10.1186/s12887-026-06634-8 [doi] LID - 247 AB - AIM: To test whether the 3-min Walk Test is a valid alternative to the 6-min Walk Test in typically developing children. METHOD: Prospective study involving typically developing children at primary school was undertaken. The distance (m) covered during long-distance walking was measured using the 6-min Walk Test and recorded at 3 and 6 minutes. RESULTS: 1512 typically developing children from 12 schools were measured. The children's ages ranged from 6 to 12 years old, with a mean age of 9.4 years (SD 1.8), and 761 (50%) were male. The mean distance covered during the 6-min Walk Test was 628 m (SD 77) and 325 m (SD 41) during the 3-min Walk Test. Mean distance covered during the 6-min Walk Test was 1.9 times the distance covered during 3-min Walk Test and this relationship held true for both sexes until age 12 years old where it increased to 2.0 times. Correlation between the distance covered in the 6-min Walk Test and the 3-min Walk Test was very strong, at r = 0.91 (95% CI 0.90 to 0.92). Hold out validation showed that the model was not overfitting, and prediction accuracy was supported by a small standard error of estimate, suggesting that the results are generalizable. DISCUSSIONS/ CONCLUSIONS: The 3-min Walk Test is a valid alternative to the 6-min Walk Test in typically developing children and it can be used to predict the 6-min Walk Test. FAU - Bania, Theofani AU - Bania T AD - Department of Physiotherapy, University of Patras, Patras, Greece. FAU - Ada, Louise AU - Ada L AD - Discipline of Physiotherapy, The University of Sydney, Sydney, Australia. FAU - Chiu, Hsiu-Ching AU - Chiu HC AD - Department of Physical Therapy, I-Shou University, Kaohsiung, Taiwan. hsiuchingchiu@isu.edu.tw. LA - eng GR - MOST 110-2320-B-214 -005/National Science and Technology Council/ GR - NSTC 113-2320-B-214 -004 -MY3/National Science and Technology Council of Taiwan/ PT - Journal Article PT - Validation Study DEP - 20260224 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Child MH - *Walk Test/methods MH - Prospective Studies MH - Male MH - Female MH - Reproducibility of Results MH - *Walking/physiology MH - *Child Development MH - *Exercise Test/methods MH - Time Factors PMC - PMC13040960 OTO - NOTNLM OT - 3-min walk test OT - 6-min walk test OT - School-aged children OT - Typical development COIS- Declarations. Ethics approval and consent to participate: The study was performed in compliance with the ethical principles of the Declaration of Helsinki. Ethical approval was secured from the National Cheng Kung University Human Research Ethics Committee (Approval No: NCKU HREC-E-108-467-2, 2020), and informed consent was obtained from all participants and their parents/guardians. Consent for publication: Not applicable -no individual person's data in any form is presented. Competing interests: The authors declare no competing interests. EDAT- 2026/02/25 00:29 MHDA- 2026/06/28 00:38 PMCR- 2026/02/24 CRDT- 2026/02/24 23:46 PHST- 2025/05/18 00:00 [received] PHST- 2026/02/10 00:00 [accepted] PHST- 2026/06/28 00:38 [medline] PHST- 2026/02/25 00:29 [pubmed] PHST- 2026/02/24 23:46 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - 10.1186/s12887-026-06634-8 [pii] AID - 6634 [pii] AID - 10.1186/s12887-026-06634-8 [doi] PST - epublish SO - BMC Pediatr. 2026 Feb 24;26(1):247. doi: 10.1186/s12887-026-06634-8. PMID- 41735531 OWN - NLM STAT- In-Process LR - 20260831 IS - 1530-0447 (Electronic) IS - 0031-3998 (Print) IS - 0031-3998 (Linking) VI - 100 IP - 1 DP - 2026 Jul TI - Bridging the gap in paediatric MASLD screening: progress, pitfalls and the path ahead. PG - 40-42 LID - 10.1038/s41390-026-04763-5 [doi] AB - With a significant rise in the number of children with obesity worldwide, there has been a parallel increase in metabolic dysfunction-associated steatotic liver disease (MASLD), now the most common chronic liver disease in youth. MASLD remains substantially underdiagnosed, largely due to its asymptomatic early course, variability in guideline-recommended screening thresholds, and limited access to paediatric-specific diagnostic tools. In a large real-world cohort of 908 overweight and obese children, Lehtinen et al. provide one of the most comprehensive evaluations of MASLD screening implementation in routine care. Whilst screening uptake for ALT and metabolic comorbidities was high and broadly in line with international guidelines, under-recognition persisted, with retrospective MASLD prevalence nearly double clinician-documented rates. The study highlights limitations of ALT-based screening and inconsistent diagnostic criteria. It also reinforces the importance of structured exclusion testing to avoid misclassification of inherited or treatable liver diseases as MASLD. Current non-invasive tools for steatosis and fibrosis remain inadequately validated in children, underscoring an urgent unmet need in paediatric hepatology. Together, these findings emphasise the necessity for harmonised screening pathways, improved diagnostic algorithms, and broader access to practical non-invasive tools to enable earlier MASLD detection and intervention. FAU - Vimalesvaran, Sunitha AU - Vimalesvaran S AD - Department of Paediatric Gastroenterology, Hepatology and Nutrition, National University Hospital, Singapore, Singapore. FAU - Dhawan, Anil AU - Dhawan A AD - Paediatric Liver, GI and Nutrition Center and Mowat Labs, King's College Hospital, London, UK. anil.dhawan@kcl.ac.uk. LA - eng PT - Journal Article DEP - 20260224 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM PMC - PMC13524827 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/02/25 00:29 MHDA- 2026/02/25 00:29 PMCR- 2026/02/24 CRDT- 2026/02/24 23:26 PHST- 2025/11/30 00:00 [received] PHST- 2025/12/22 00:00 [accepted] PHST- 2026/02/25 00:29 [pubmed] PHST- 2026/02/25 00:29 [medline] PHST- 2026/02/24 23:26 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - 10.1038/s41390-026-04763-5 [pii] AID - 4763 [pii] AID - 10.1038/s41390-026-04763-5 [doi] PST - ppublish SO - Pediatr Res. 2026 Jul;100(1):40-42. doi: 10.1038/s41390-026-04763-5. Epub 2026 Feb 24. PMID- 41735280 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260828 IS - 2041-1723 (Electronic) IS - 2041-1723 (Linking) VI - 17 IP - 1 DP - 2026 Feb 24 TI - Clinically distinct metabotypes of pediatric MASLD identified through unsupervised clustering of NASH CRN data. LID - 10.1038/s41467-026-69735-z [doi] LID - 3107 AB - Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common liver disease worldwide, yet treatment remains "one size fits all," despite phenotypic heterogeneity. We analyzed clinical and metabolomics data from 514 children (ages 5-18, 73% male) with biopsy-proven MASLD across three NASH Clinical Research Network studies. Unsupervised clustering of clinical data identified three distinct metabotypes: early-mild (49.4%, youngest, lowest lipids, liver enzymes, insulin resistance), cardiometabolic (36.8%, highest waist circumference, lipids, uric acid, SBP), and inflammatory-fibrotic (13.8%, highest liver enzymes, steatohepatitis, advanced fibrosis). Integrative network and pathway enrichment analyses revealed alterations in tryptophan metabolism within the inflammatory-fibrotic group, including elevated kynurenine pathway metabolites, which were significantly correlated with fibrosis stage. Branched-chain amino acid degradation, butanoate, and purine metabolism demonstrated greater enrichment in the cardiometabolic group. Here, we show that pediatric MASLD subtypes differ in clinical and metabolic features, providing a framework for targeted interventions, with validation needed in independent cohorts. CI - (c) 2026. The Author(s). FAU - Huneault, Helaina E AU - Huneault HE AUID- ORCID: 0000-0003-3866-2387 AD - Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA. hhuneau@emory.edu. AD - Department of Pediatrics and Human Development, Michigan State University, College of Human Medicine, Grand Rapids, MI, USA. hhuneau@emory.edu. FAU - Tiwari, Pradeep AU - Tiwari P AD - Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. AD - VA Healthcare System of Atlanta, Decatur, GA, USA. FAU - Jarrell, Zachery R AU - Jarrell ZR AUID- ORCID: 0000-0003-4670-1497 AD - Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. FAU - Smith, Matthew Ryan AU - Smith MR AUID- ORCID: 0000-0002-8889-3477 AD - VA Healthcare System of Atlanta, Decatur, GA, USA. AD - Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. FAU - Chen, Chih-Yu AU - Chen CY AD - Emory Integrated Metabolomics and Lipidomics Core, School of Medicine, Emory University, Atlanta, GA, USA. FAU - Ramirez Tovar, Ana AU - Ramirez Tovar A AD - Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA. AD - Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Emory University, Atlanta, GA, USA. FAU - Sanchez-Torres, Cristian AU - Sanchez-Torres C AD - Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Emory University, Atlanta, GA, USA. FAU - Gillespie, Scott AU - Gillespie S AD - Pediatric Biostatistics Core, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA. FAU - Bai, Shasha AU - Bai S AD - Pediatric Biostatistics Core, Department of Pediatrics, School of Medicine, Emory University, Atlanta, GA, USA. FAU - Carrillo-Larco, Rodrigo M AU - Carrillo-Larco RM AD - Hubert Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, GA, USA. FAU - Jain, Ajay K AU - Jain AK AD - Department of Pediatrics, Saint Louis University School of Medicine, Saint Louis, MO, USA. FAU - Yates, Katherine P AU - Yates KP AUID- ORCID: 0000-0001-6138-2194 AD - Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Neuschwander-Tetri, Brent A AU - Neuschwander-Tetri BA AUID- ORCID: 0000-0002-8520-7398 AD - Department of Internal Medicine, Saint Louis University, St. Louis, Missouri, USA. FAU - Schwimmer, Jeffrey B AU - Schwimmer JB AD - Department of Gastroenterology, Rady Children's Hospital San Diego, San Diego, CA, USA. AD - Department of Pediatrics, School of Medicine, University of California, San Diego, La Jolla, CA, USA. FAU - Xanthakos, Stavra A AU - Xanthakos SA AD - Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA. FAU - Molleston, Jean P AU - Molleston JP AD - Department of Pediatrics, Indiana University/Riley Hospital for Children, Indianapolis, IN, USA. FAU - Behling, Cynthia A AU - Behling CA AD - Sharp Memorial Hospital, San Diego, California, USA. FAU - Fishbein, Mark H AU - Fishbein MH AD - Department of Pediatrics, Feinberg School of Medicine at Northwestern University, Chicago, IL, USA. FAU - Hartman, Terryl J AU - Hartman TJ AD - Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA. AD - Department of Epidemiology, Rollins School of Public Health and Winship Cancer Institute, Emory University, Atlanta, GA, USA. FAU - Pasquel, Francisco J AU - Pasquel FJ AUID- ORCID: 0000-0002-3845-6703 AD - Division of Endocrinology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. FAU - Kamaleswaran, Rishikesan AU - Kamaleswaran R AD - Department of Surgery, Duke University School of Medicine, Durham, NC, USA. AD - Department of Anesthesiology, Duke University School of Medicine, Durham, NC, USA. FAU - Jones, Dean P AU - Jones DP AUID- ORCID: 0000-0002-2090-0677 AD - Division of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. FAU - Welsh, Jean A AU - Welsh JA AD - Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA. AD - Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Emory University, Atlanta, GA, USA. AD - Children's Healthcare of Atlanta, Atlanta, GA, USA. FAU - Vos, Miriam B AU - Vos MB AD - Nutrition & Health Sciences Program, Laney Graduate School, Emory University, Atlanta, GA, USA. AD - Department of Pediatrics and Human Development, Michigan State University, College of Human Medicine, Grand Rapids, MI, USA. AD - Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, Emory University, Atlanta, GA, USA. AD - Children's Healthcare of Atlanta, Atlanta, GA, USA. AD - Helen DeVos Children's Hospital, Corewell Health, Grand Rapids, MI, USA. LA - eng GR - U01 DK061732/DK/NIDDK NIH HHS/United States GR - UL1TR002378 (MBV), UL1TR000454 (MBV), and UL1TR000448 (MBV)/U.S. Department of Health & Human Services | NIH | National Center for Advancing Translational Sciences (NCATS)/ GR - R01 NR019083/NR/NINR NIH HHS/United States GR - IK2 BX005913/BX/BLRD VA/United States GR - U24 DK061730/DK/NIDDK NIH HHS/United States GR - R21 AI169487/AI/NIAID NIH HHS/United States GR - K23 DK080953/DK/NIDDK NIH HHS/United States GR - R01 DK131136/DK/NIDDK NIH HHS/United States GR - K24 HL171937/HL/NHLBI NIH HHS/United States GR - R01 DK125701/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20260224 PL - England TA - Nat Commun JT - Nature communications JID - 101528555 SB - IM MH - Humans MH - Male MH - Child MH - *Non-alcoholic Fatty Liver Disease/metabolism/pathology MH - Child, Preschool MH - Female MH - Metabolomics/methods MH - Adolescent MH - Clustering Algorithms MH - Liver/pathology/metabolism MH - Cluster Analysis MH - *Metabolome MH - Liver Cirrhosis/metabolism/pathology MH - *Fatty Liver/metabolism PMC - PMC13039967 COIS- Competing interests: MBV serves as a consultant to Boehringer Ingelheim, Novo Nordisk, Eli Lilly, Intercept, Takeda, and Alberio. She has stock or stock options in Thiogenesis and Tern Pharmaceuticals. Her institution has received research grants (or in-kind research services) from Target Real World Evidence, Quest, Labcorp, and Sonic Incytes Medical Corp. JPM has research grant funding from Gilead, Abbvie, Albireo, and Mirum. BANT: Advisor or consultant: Abbvie, Akero, Aldeyra, Aligos, Arrowhead, Corcept, Galectin, GSK, Hepion, HistoIndex, Madrigal, Merck, Mirum, Pfizer, Sagimet, Senseion; Stock options: HepGene, HeptaBio; Institutional research grants: Madrigal. SAX: Institutional research grants: Target Real World Evidence. The remaining authors declare no competing interests. EDAT- 2026/02/25 00:29 MHDA- 2026/04/01 00:28 PMCR- 2026/02/24 CRDT- 2026/02/24 23:14 PHST- 2025/02/12 00:00 [received] PHST- 2026/01/28 00:00 [accepted] PHST- 2026/04/01 00:28 [medline] PHST- 2026/02/25 00:29 [pubmed] PHST- 2026/02/24 23:14 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - 10.1038/s41467-026-69735-z [pii] AID - 69735 [pii] AID - 10.1038/s41467-026-69735-z [doi] PST - epublish SO - Nat Commun. 2026 Feb 24;17(1):3107. doi: 10.1038/s41467-026-69735-z. PMID- 41735242 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260921 IS - 1365-2982 (Electronic) IS - 1350-1925 (Print) IS - 1350-1925 (Linking) VI - 38 IP - 2 DP - 2026 Feb TI - Percutaneous Electrical Nerve Field Stimulation Improves Weight and Other Anthropometric Outcomes in Children and Adolescents With Functional Dyspepsia Who Restrict Their Oral Intake. PG - e70273 LID - 10.1111/nmo.70273 [doi] AB - BACKGROUND: Functional dyspepsia (FD), a disorder of the gut-brain interaction (DGBI), can result in restricted eating habits with associated weight loss. Percutaneous Electrical Nerve Field Stimulation (PENFS), a minimally invasive non-pharmacologic approach, can improve abdominal pain and psychological functioning in children with DGBI. We aimed to analyze changes in anthropometric measures, nutritional intake, and clinical outcomes with PENFS. METHODS: We retrospectively reviewed charts of patients with FD (9-28 years) who restricted oral intake and underwent PENFS. We analyzed validated questionnaires used during treatment. Anthropometric data were also assessed during and after 3 months of treatment. Results were analyzed through linear mixed modeling as least square means. KEY RESULTS: Ninety patients reported restricted oral intake, 42% had baseline weight loss and 13% requiring enteral support. Oral intake (p = 0.001), weight (p = 0.02) and BMI (p = 0.002) significantly increased after PENFS. Abdominal pain, nausea, functional disability, depression, and somatization also improved after PENFS. Increased weight Z scores were associated with lower nausea, pain catastrophizing, and depression. CONCLUSIONS AND INFERENCES: PENFS improved oral intake, weight, and other anthropometric measures in addition to GI and psychological measures in patients with FD. Changes in anthropometrics were sustained at 3-month follow up. PENFS may be an effective treatment for patients with FD, including children, and restrictive eating to optimize nutritional outcomes. Future studies should include prospective clinical trials and investigate the mechanism of action of PENFS on eating habits. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Waheed, Umber AU - Waheed U AD - Pediatrics, University of Cincinnati College of Medicine (UCCOM), Cincinnati, Ohio, USA. AD - Gastroenterology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio, USA. FAU - VonAxelson, Austin AU - VonAxelson A AD - Pediatrics, University of Cincinnati College of Medicine (UCCOM), Cincinnati, Ohio, USA. FAU - El-Chammas, Khalil AU - El-Chammas K AD - Pediatrics, University of Cincinnati College of Medicine (UCCOM), Cincinnati, Ohio, USA. AD - Gastroenterology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio, USA. FAU - Graham, Kahleb AU - Graham K AD - Pediatrics, University of Cincinnati College of Medicine (UCCOM), Cincinnati, Ohio, USA. AD - Gastroenterology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio, USA. FAU - Mansi, Sherief AU - Mansi S AD - Pediatrics, University of Cincinnati College of Medicine (UCCOM), Cincinnati, Ohio, USA. AD - Gastroenterology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio, USA. FAU - Hardy, Jennifer AU - Hardy J AD - Gastroenterology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio, USA. FAU - Miller, Megan M AU - Miller MM AUID- ORCID: 0000-0002-6222-2659 AD - Behavioral Medicine and Clinical Psychology, CCHMC, Cincinnati, Ohio, USA. FAU - Sahay, Rashmi AU - Sahay R AD - Biostatistics, CCHMC, Cincinnati, Ohio, USA. FAU - Santucci, Neha R AU - Santucci NR AD - Gastroenterology, Cincinnati Children's Hospital Medical Center (CCHMC), Cincinnati, Ohio, USA. LA - eng GR - K23 DK135797/DK/NIDDK NIH HHS/United States PT - Journal Article PL - England TA - Neurogastroenterol Motil JT - Neurogastroenterology and motility JID - 9432572 SB - IM MH - Humans MH - *Dyspepsia/therapy/physiopathology/psychology MH - Female MH - Child MH - Adolescent MH - Male MH - Retrospective Studies MH - *Transcutaneous Electric Nerve Stimulation/methods MH - Treatment Outcome MH - Adult MH - Young Adult MH - *Body Weight/physiology MH - Weight Loss MH - Anthropometry MH - Abdominal Pain PMC - PMC13086553 MID - NIHMS2157096 OTO - NOTNLM OT - abdominal pain OT - functional dyspepsia OT - restricted eating OT - vagal neuromodulation OT - weight loss COIS- Conflicts of Interest Dr. Santucci is a consultant for Ironwood and a key opinion leader for Kate Farms and GI Health Foundation. Dr. Khalil El-Chammas is a consultant for Neuraxis Inc. who is responsible for IB-Stim, PENFS technology. EDAT- 2026/02/25 00:29 MHDA- 2026/02/25 00:30 PMCR- 2026/04/17 CRDT- 2026/02/24 23:03 PHST- 2026/01/22 00:00 [revised] PHST- 2025/10/23 00:00 [received] PHST- 2026/02/15 00:00 [accepted] PHST- 2026/02/25 00:30 [medline] PHST- 2026/02/25 00:29 [pubmed] PHST- 2026/02/24 23:03 [entrez] PHST- 2026/04/17 00:00 [pmc-release] AID - 10.1111/nmo.70273 [doi] PST - ppublish SO - Neurogastroenterol Motil. 2026 Feb;38(2):e70273. doi: 10.1111/nmo.70273. PMID- 41735142 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260709 IS - 2341-2879 (Electronic) IS - 2341-2879 (Linking) VI - 104 IP - 3 DP - 2026 Mar TI - A scoping review of methods of measuring smartphone usage. PG - 504156 LID - S2341-2879(26)00055-4 [pii] LID - 10.1016/j.anpede.2026.504156 [doi] AB - INTRODUCTION: Screen usage patterns have shifted significantly in recent years, with a notable increase in the use of internet-enabled smartphones among children and adolescents. OBJECTIVE: The aim of this scoping review was to describe the measurement tools used to estimate smartphone screen time in individuals aged less than 18 years. METHODS: We conducted a systematic search in MEDLINE Complete (via PubMed) and ScienceDirect for studies published between May 2014 and May 2024. A total of 89 population-based surveillance studies were included for analysis. RESULTS: The most common assessment method was the use of non-validated self-report questionnaires completed by parents. Only seven studies used a validated instrument, and in six of these cases, the tool was not specifically designed to measure screen time. Only one study applied a validated scale developed expressly for this purpose: the Screen Time Questionnaire (STQ). CONCLUSION: The heterogeneity of current findings on smartphone usage time among minors is evident. There is a clear need for a standardized questionnaire to accurately measure this variable and to support the development of evidence-based guidelines and recommendations. CI - Copyright (c) 2026 Asociacion Espanola de Pediatria. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Cendrero-Luengo, Carmen AU - Cendrero-Luengo C AD - Grupo de Evaluacion de Determinantes de la Salud y Politicas Sanitarias, Universidad de Extremadura, Merida, Badajoz, Spain; Centro de estudios del uso saludable de pantallas durante la infancia (Kenko Lab), Spain. FAU - de Paz-Cantos, Sonia AU - de Paz-Cantos S AD - Centro de estudios del uso saludable de pantallas durante la infancia (Kenko Lab), Spain; Grupo de Evaluacion de Determinantes de Salud y Politicas Sanitarias, Departamento de Medicina, Universitat Internacional de Catalunya, Sant Cugat del Valles, Barcelona, Spain. FAU - Gonzalez-Marron, Adrian AU - Gonzalez-Marron A AD - Centro de estudios del uso saludable de pantallas durante la infancia (Kenko Lab), Spain; Grupo de Evaluacion de Determinantes de Salud y Politicas Sanitarias, Departamento de Medicina, Universitat Internacional de Catalunya, Sant Cugat del Valles, Barcelona, Spain. FAU - Lidon-Moyano, Cristina AU - Lidon-Moyano C AD - Centro de estudios del uso saludable de pantallas durante la infancia (Kenko Lab), Spain; Grupo de Evaluacion de Determinantes de Salud y Politicas Sanitarias, Departamento de Medicina, Universitat Internacional de Catalunya, Sant Cugat del Valles, Barcelona, Spain. FAU - Diez-Izquierdo, Ana AU - Diez-Izquierdo A AD - Centro de estudios del uso saludable de pantallas durante la infancia (Kenko Lab), Spain; Seccion de Neumologia y Alergologia Pediatricas, Servicio de Pediatria, Hospital Universitari Vall d'Hebron, Barcelona, Spain. FAU - Martinez-Sanchez, Jose M AU - Martinez-Sanchez JM AD - Grupo de Evaluacion de Determinantes de la Salud y Politicas Sanitarias, Universidad de Extremadura, Merida, Badajoz, Spain; Grupo de Evaluacion de Determinantes de Salud y Politicas Sanitarias, Departamento de Medicina, Universitat Internacional de Catalunya, Sant Cugat del Valles, Barcelona, Spain. Electronic address: jmmartinezs@unex.es. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260223 PL - Spain TA - An Pediatr (Engl Ed) JT - Anales de pediatria JID - 101765626 SB - IM MH - Humans MH - *Smartphone/statistics & numerical data MH - Child MH - Surveys and Questionnaires MH - Adolescent MH - *Screen Time MH - Self Report OTO - NOTNLM OT - Child health OT - Encuestas y cuestionarios OT - Media use OT - Mobile phone use OT - Public health OT - Salud infantil OT - Salud publica OT - Screen time OT - Surveys and questionnaires OT - Tiempo de pantalla OT - Uso de medios OT - Uso de telefono movil COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2026/02/25 00:30 MHDA- 2026/03/17 00:33 CRDT- 2026/02/24 21:58 PHST- 2025/07/24 00:00 [received] PHST- 2025/11/10 00:00 [accepted] PHST- 2026/03/17 00:33 [medline] PHST- 2026/02/25 00:30 [pubmed] PHST- 2026/02/24 21:58 [entrez] AID - S2341-2879(26)00055-4 [pii] AID - 10.1016/j.anpede.2026.504156 [doi] PST - ppublish SO - An Pediatr (Engl Ed). 2026 Mar;104(3):504156. doi: 10.1016/j.anpede.2026.504156. Epub 2026 Feb 23. PMID- 41735047 OWN - NLM STAT- MEDLINE DCOM- 20260709 LR - 20260729 IS - 1468-2044 (Electronic) IS - 0003-9888 (Linking) VI - 111 IP - 6 DP - 2026 May 18 TI - Integrating an exercise specialist supported by mHealth technology to increase exercise and physical activity adherence in a paediatric Complications from Excess Weight Service (MOTIVATE-CEW): a feasibility study. PG - 532-538 LID - 10.1136/archdischild-2025-329092 [doi] AB - OBJECTIVES: Assess the feasibility of embedding an exercise specialist-led, mHealth-supported physical activity and exercise intervention (MOTIVATE-CEW) into a UK Complications from Excess Weight (CEW) service. DESIGN: Feasibility, single-site, parallel-group randomised controlled trial. SETTING: Participants were recruited from Alder Hey Children's Hospital (AHCH) CEW service. PATIENTS: Young people (12-18 years) receiving care from the AHCH CEW service. INTERVENTIONS: Participants were randomised 1:1 to usual care or usual care and intervention (MOTIVATE-CEW). MOTIVATE-CEW participants codesigned a 3-month, home-delivered, personalised progressive physical activity programme supported by virtual counselling sessions from an exercise specialist and biofeedback from wearable technologies. MAIN OUTCOME MEASURES: The primary outcomes were recruitment rate, retention and adherence to purposeful exercise. Exploratory clinical data on effectiveness were collected at baseline and post-intervention (3 months). RESULTS: n=72 young people aged over 12 years were registered with the AHCH CEW service and approached to participate. n=25 were ultimately randomised (age 15+/-1; 52% female; 84% white), giving a recruitment rate of 27%. Retention at 3 months was 88%. Over the 3-month intervention, heart rate monitor data suggested MOTIVATE-CEW participants completed more exercise sessions (MOTIVATE-CEW 2+/-2 sessions/week; usual care 0+/-0 sessions/week; d=1.04) and exercised for longer (MOTIVATE-CEW 80+/-102 min/week; usual care 8+/-20 min/week; d=0.99) than usual care. At 3 months, 33% of MOTIVATE-CEW participants were still exercising compared with 8% in usual care. CONCLUSIONS: The MOTIVATE-CEW intervention showed promising effects on exercise behaviour. Good reach and data availability suggest the study design could be feasible within future trials. TRIAL REGISTRATION NUMBER: NCT04854915. CI - (c) Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Davies, Andrew Paul AU - Davies AP AUID- ORCID: 0000-0002-9006-5881 AD - Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK. FAU - Hesketh, Katie Louise AU - Hesketh KL AD - Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK. AD - School of Sport Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK. FAU - Apperley, Louise Jayne AU - Apperley LJ AUID- ORCID: 0000-0002-6325-146X AD - Department of Paediatric Endocrinology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK. FAU - Clarke, Ellie AU - Clarke E AD - Department of Paediatric Endocrinology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK. FAU - Crozier, Anthony AU - Crozier A AUID- ORCID: 0000-0002-5444-397X AD - Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK. FAU - Russon, Catherine AU - Russon C AD - University of Exeter Medical School, Exeter, UK. FAU - Sprung, Victoria Sally AU - Sprung VS AUID- ORCID: 0000-0002-2666-4986 AD - Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK. FAU - Jones, Helen AU - Jones H AD - Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK. FAU - Kinnafick, Florence AU - Kinnafick F AD - School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK. FAU - Senniappan, Senthil AU - Senniappan S AD - Department of Paediatric Endocrinology, Alder Hey Children's NHS Foundation Trust, Liverpool, UK. FAU - Cocks, Matthew AU - Cocks M AUID- ORCID: 0000-0003-1671-8714 AD - Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK M.S.Cocks@ljmu.ac.uk. LA - eng SI - ClinicalTrials.gov/NCT04854915 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260518 PL - England TA - Arch Dis Child JT - Archives of disease in childhood JID - 0372434 SB - IM MH - Humans MH - Female MH - Adolescent MH - Feasibility Studies MH - Child MH - Male MH - *Patient Compliance/statistics & numerical data MH - Telemedicine MH - *Exercise Therapy/methods MH - *Exercise MH - Digital Health MH - United Kingdom MH - Adherence Interventions MH - Motivation OTO - NOTNLM OT - Adolescent Health OT - Endocrinology OT - Obesity OT - Paediatrics OT - Technology COIS- Competing interests: None declared. EDAT- 2026/02/25 00:29 MHDA- 2026/05/19 00:28 CRDT- 2026/02/24 21:33 PHST- 2025/06/16 00:00 [received] PHST- 2026/02/03 00:00 [accepted] PHST- 2026/05/19 00:28 [medline] PHST- 2026/02/25 00:29 [pubmed] PHST- 2026/02/24 21:33 [entrez] AID - archdischild-2025-329092 [pii] AID - 10.1136/archdischild-2025-329092 [doi] PST - epublish SO - Arch Dis Child. 2026 May 18;111(6):532-538. doi: 10.1136/archdischild-2025-329092. PMID- 41734444 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260710 IS - 1472-6491 (Electronic) IS - 1472-6483 (Linking) VI - 52 IP - 4 DP - 2026 Apr TI - Association between the adherence to different dietary patterns and sperm chromatin integrity in healthy men. PG - 105356 LID - S1472-6483(25)00563-2 [pii] LID - 10.1016/j.rbmo.2025.105356 [doi] AB - RESEARCH QUESTION: Are healthy and unhealthy diets associated with sperm DNA fragmentation and chromatin deprotamination in healthy men of reproductive age? DESIGN: A cross-sectional analysis conducted using healthy male volunteers (n = 200), aged 18-40 years, participating in the Led-Fertyl study. Adherence to five dietary patterns were estimated using a-priori indices: Mediterranean diet (Mediterranean Diet Adherence Screener; [MEDAS]); healthy and unhealthy plant-based diets; EAT-Lancet diet and Western diet. Dietary intake was assessed using a validated 143-item Food Frequency Questionnaire. Double-strand DNA fragmentation in spermatozoa evaluated by the Neutral Comet assay and chromatin deprotamination evaluated through chromomycin A3 (CMA3) staining by flow cytometry, were considered the main outcomes. RESULTS: No association between adherence to MEDAS, healthy and unhealthy plant-based, EAT-Lancet or Western dietary patterns with sperm DNA fragmentation was observed. Furthermore, adherence to MEDAS, healthy plant-based, EAT-Lancet or Western dietary patterns did not differ in sperm chromatin deprotamination. Yet, adherence to the unhealthy plant-based diet was non-linearly associated with increased chromatin deprotamination in all statistical models. Compared with the lowest tertile, participants in the highest unhealthy plant-based tertile had greater sperm chromatin deprotamination (beta = 12.4, 95% CI 2.7 to 22.1, P = 0.026), suggesting a higher occurrence of abnormalities in sperm chromatin condensation. CONCLUSION: To the best of our knowledge, this study is the first to epidemiologically investigate the relationship between dietary patterns and sperm chromatin integrity, highlighting that adherence to unhealthy plant-based diets may lead to sperm chromatin abnormalities. These findings underscore the potential effect of specific dietary patterns on molecular sperm quality parameters and support further research into dietary strategies for optimizing sperm integrity and improving male fertility. CI - Copyright (c) 2025 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Llavanera, Marc AU - Llavanera M AD - Laboratory of Chromosome Biology, Max Planck Institute of Biochemistry, DE-82152 Martinsried, Germany; Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, ES-17003 Girona, Spain. FAU - Fernandez de la Puente, Maria AU - Fernandez de la Puente M AD - Universitat Rovira i Virgili, Unitat de Nutricio Humana, Departament de Bioquimica i Biotecnologia. Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), ES-43201 Reus, Spain; Institut d'Investigacio Sanitaria Pere Virgili (IISPV), ES-43204 Reus, Spain; Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, ES-28029 Madrid, Spain. FAU - Davila-Cordova, Estefania AU - Davila-Cordova E AD - Universitat Rovira i Virgili, Unitat de Nutricio Humana, Departament de Bioquimica i Biotecnologia. Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), ES-43201 Reus, Spain; Institut d'Investigacio Sanitaria Pere Virgili (IISPV), ES-43204 Reus, Spain. FAU - Eigbefoh-Addeh, Ailende AU - Eigbefoh-Addeh A AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), ES-43204 Reus, Spain; Universitat Rovira i Virgili, Unit of Preventive Medicine and Biostatistics, Department of Basic Medical Sciences. Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), ES-43201 Reus, Spain. FAU - Agarwal, Rashmi AU - Agarwal R AD - Universitat Rovira i Virgili, Unitat de Nutricio Humana, Departament de Bioquimica i Biotecnologia. Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), ES-43201 Reus, Spain; Institut d'Investigacio Sanitaria Pere Virgili (IISPV), ES-43204 Reus, Spain. FAU - Valle-Hita, Cristina AU - Valle-Hita C AD - Universitat Rovira i Virgili, Unitat de Nutricio Humana, Departament de Bioquimica i Biotecnologia. Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), ES-43201 Reus, Spain; Institut d'Investigacio Sanitaria Pere Virgili (IISPV), ES-43204 Reus, Spain; Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, ES-28029 Madrid, Spain; Section of Epidemiology, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Denmark. FAU - Babio, Nancy AU - Babio N AD - Universitat Rovira i Virgili, Unitat de Nutricio Humana, Departament de Bioquimica i Biotecnologia. Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), ES-43201 Reus, Spain; Institut d'Investigacio Sanitaria Pere Virgili (IISPV), ES-43204 Reus, Spain; Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, ES-28029 Madrid, Spain. FAU - Salas-Salvado, Jordi AU - Salas-Salvado J AD - Universitat Rovira i Virgili, Unitat de Nutricio Humana, Departament de Bioquimica i Biotecnologia. Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), ES-43201 Reus, Spain; Institut d'Investigacio Sanitaria Pere Virgili (IISPV), ES-43204 Reus, Spain; Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, ES-28029 Madrid, Spain; Catalan Institution for Research and Advanced Studies (ICREA), ES-08010 Barcelona, Spain. FAU - Yeste, Marc AU - Yeste M AD - Biotechnology of Animal and Human Reproduction (TechnoSperm), Institute of Food and Agricultural Technology, University of Girona, ES-17003 Girona, Spain; Universitat Rovira i Virgili, Unit of Preventive Medicine and Biostatistics, Department of Basic Medical Sciences. Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), ES-43201 Reus, Spain; Catalan Institution for Research and Advanced Studies (ICREA), ES-08010 Barcelona, Spain; Unit of Cell Biology, Department of Biology, Faculty of Sciences, University of Girona, ES-17003 Girona, Spain. FAU - Salas-Huetos, Albert AU - Salas-Huetos A AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), ES-43204 Reus, Spain; Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, ES-28029 Madrid, Spain; Universitat Rovira i Virgili, Unit of Preventive Medicine and Biostatistics, Department of Basic Medical Sciences. Alimentacio, Nutricio, Desenvolupament i Salut Mental (ANUT-DSM), ES-43201 Reus, Spain; Department of Nutrition, Harvard T.H. Chan School of Public Health, US-02115 Boston, Massachusetts, USA. Electronic address: albert.salas@urv.cat. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251020 PL - Netherlands TA - Reprod Biomed Online JT - Reproductive biomedicine online JID - 101122473 RN - 0 (Chromatin) SB - IM MH - Humans MH - Male MH - *Spermatozoa/metabolism MH - Adult MH - *Chromatin/metabolism MH - *DNA Fragmentation MH - Young Adult MH - Adolescent MH - Cross-Sectional Studies MH - Diet, Mediterranean MH - Diet, Western MH - Diet, Plant-Based MH - *Diet MH - Diet, Vegetarian OTO - NOTNLM OT - DNA fragmentation OT - Dietary patterns OT - Male fertility OT - Plant-based diet OT - Sperm chromatin integrity EDAT- 2026/02/25 00:29 MHDA- 2026/04/21 17:42 CRDT- 2026/02/24 18:02 PHST- 2025/06/05 00:00 [received] PHST- 2025/09/23 00:00 [revised] PHST- 2025/10/14 00:00 [accepted] PHST- 2026/04/21 17:42 [medline] PHST- 2026/02/25 00:29 [pubmed] PHST- 2026/02/24 18:02 [entrez] AID - S1472-6483(25)00563-2 [pii] AID - 10.1016/j.rbmo.2025.105356 [doi] PST - ppublish SO - Reprod Biomed Online. 2026 Apr;52(4):105356. doi: 10.1016/j.rbmo.2025.105356. Epub 2025 Oct 20. PMID- 41734348 OWN - NLM STAT- Publisher LR - 20260224 IS - 0265-539X (Print) IS - 0265-539X (Linking) DP - 2026 Feb 24 TI - Cariology in pediatric dentistry: An updated evidence-based narrative review. PG - 265539X261430268 LID - 10.1177/0265539X261430268 [doi] AB - Despite notable progress in understanding the pediatric dental caries area, its multifactorial etiology-including biofilm dynamics, dietary habits, host factors, and social determinants-the burden of untreated caries persists, particularly in socioeconomically disadvantaged populations. This systematic review aimed to synthesize the evidence on [intervention/exposure] in the management of early childhood caries. Advances such as the use of the International Caries Detection and Assessment System (ICDAS), risk-based management, and noninvasive or microinvasive interventions-including professional fluoride application, silver diamine fluoride, resin infiltration, sealants, and atraumatic restorative treatment-have improved early lesion identification and patient-specific care, prioritized the preservation of tooth structure and pulp vitality, and reduced the need for extensive restorative procedures. Nevertheless, significant challenges remain in translating these protocols to routine practice, including variability in provider training, healthcare infrastructure limitations, socioeconomic and cultural disparities, and inconsistent guideline implementation. The integration of digital and artificial intelligence technologies, alongside teleodontology, holds promise for improving diagnostic accuracy, reducing access barriers, and facilitating early intervention-especially for underserved populations. However, the findings from this review should be interpreted with caution due to the heterogeneity of study designs, diagnostic criteria, and outcome measures, as well as the potential risk of bias. Ongoing research is essential for understanding the cost-effectiveness, long-term outcomes, and real-world applicability of these contemporary protocols. The widespread adoption of biologically oriented, patient-centered principles and interdisciplinary collaboration is key to reducing the global burden of dental caries and achieving equitable pediatric oral health outcomes. FAU - Pozos-Guillen, Amaury AU - Pozos-Guillen A AD - Pediatric Dentistry Postgraduate Program, Faculty of Dentistry, San Luis Potosi University, San Luis Potosi, Mexico. RINGGOLD: 27773 FAU - Aranda-Romo, Saray AU - Aranda-Romo S AD - Department of Microbiology, Faculty of Dentistry, San Luis Potosi University, San Luis Potosi, Mexico. RINGGOLD: 27773 FAU - Zavala-Alonso, Veronica AU - Zavala-Alonso V AD - Faculty of Dentistry, San Luis Potosi University, San Luis Potosi, Mexico. RINGGOLD: 27773 FAU - Marquez-Preciado, Raul AU - Marquez-Preciado R AD - Pediatric Dentistry Postgraduate Program, Faculty of Dentistry, San Luis Potosi University, San Luis Potosi, Mexico. RINGGOLD: 27773 FAU - Rosales-Berber, Miguel AU - Rosales-Berber M AD - Pediatric Dentistry Postgraduate Program, Faculty of Dentistry, San Luis Potosi University, San Luis Potosi, Mexico. RINGGOLD: 27773 FAU - Mejia-Cruz, Jorge AU - Mejia-Cruz J AD - Pediatric Dentistry Postgraduate Program, Faculty of Dentistry, San Luis Potosi University, San Luis Potosi, Mexico. RINGGOLD: 27773 FAU - Garrocho-Rangel, Arturo AU - Garrocho-Rangel A AUID- ORCID: 0000-0001-9123-0300 AD - Pediatric Dentistry Postgraduate Program, Faculty of Dentistry, San Luis Potosi University, San Luis Potosi, Mexico. RINGGOLD: 27773 LA - eng PT - Journal Article PT - Review DEP - 20260224 PL - England TA - Community Dent Health JT - Community dental health JID - 8411261 SB - IM OTO - NOTNLM OT - caries prevention OT - dental caries OT - early caries management OT - minimally invasive dentistry OT - pediatric dentistry EDAT- 2026/02/24 18:46 MHDA- 2026/02/24 18:46 CRDT- 2026/02/24 15:54 PHST- 2026/02/24 18:46 [medline] PHST- 2026/02/24 18:46 [pubmed] PHST- 2026/02/24 15:54 [entrez] AID - 10.1177/0265539X261430268 [doi] PST - aheadofprint SO - Community Dent Health. 2026 Feb 24:265539X261430268. doi: 10.1177/0265539X261430268. PMID- 41734092 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260708 IS - 1555-0273 (Electronic) IS - 1555-0265 (Linking) VI - 21 IP - 5 DP - 2026 May 1 TI - Reliability of 10- and 30-Second Tethered Swimming Tests in Highly Trained Swimmers: Influence of Swimming Specialty, Sex, Performance Level, and Evaluator. PG - 648-655 LID - 10.1123/ijspp.2025-0203 [doi] AB - PURPOSE: The tethered swimming test is relevant for the longitudinal monitoring of swimmers. However, for accurate interpretation of observed variations over time, understanding the reliability of the test and the factors influencing it is crucial. This study aimed to assess the absolute and relative reliability of parameters derived from 10- and 30-second front-crawl-tethered swimming tests by considering swimming specialty, sex, and performance level. Output variables resulting from manual stroke cycle segmentation were examined to evaluate interevaluator reliability. METHODS: Twenty-one highly trained swimmers performed the 2 specific time-based tests over 3 consecutive days. Relative and absolute reliability were assessed using the intraclass correlation coefficient and standard error of measurement, respectively. RESULTS: Mean force, peak force, and impulse demonstrated high reliability (intraclass correlation coefficient > .86 and .73 for 10- and 30-s tests, respectively). Fatigue index, performance decrement, and rate of performance decline exhibited varying reliability from poor to high. These results were unaffected by swimming specialty, sex, performance level, or evaluator. CONCLUSION: The findings indicate that 10- and 30-second front-crawl tethered swimming tests are highly reliable. Mean force, peak force, and impulse emerge as the most reliable parameters, regardless of the swimming specialty, sex, performance level, or evaluator. FAU - Couvertier, Marien AU - Couvertier M AUID- ORCID: 0009-0003-4212-6015 AD - Institut Prime, UPR 3346, CNRS-University of Poitiers-ISAE-ENSMA, Poitiers, France. FAU - Bretonneau, Quentin AU - Bretonneau Q AUID- ORCID: 0000-0002-9307-8688 AD - Laboratory MOVE-UR 20296-University of Poitiers, Poitiers, France. FAU - Monnet, Tony AU - Monnet T AUID- ORCID: 0000-0003-2942-2437 AD - Institut Prime, UPR 3346, CNRS-University of Poitiers-ISAE-ENSMA, Poitiers, France. FAU - Samson, Mathias AU - Samson M AD - Institut Prime, UPR 3346, CNRS-University of Poitiers-ISAE-ENSMA, Poitiers, France. FAU - Morales-Artacho, Antonio AU - Morales-Artacho A AD - Laboratory Sport, Expertise and Performance, INSEP, Paris, France. FAU - Pla, Robin AU - Pla R AUID- ORCID: 0000-0002-8504-5069 AD - Federation Francaise de Natation, Paris, France. FAU - Bosquet, Laurent AU - Bosquet L AUID- ORCID: 0000-0002-2530-2676 AD - Laboratory MOVE-UR 20296-University of Poitiers, Poitiers, France. FAU - Decatoire, Arnaud AU - Decatoire A AUID- ORCID: 0000-0003-1040-6162 AD - Institut Prime, UPR 3346, CNRS-University of Poitiers-ISAE-ENSMA, Poitiers, France. CN - D-Day Consortium LA - eng PT - Journal Article DEP - 20260223 PL - United States TA - Int J Sports Physiol Perform JT - International journal of sports physiology and performance JID - 101276430 SB - IM MH - *Swimming/physiology MH - Humans MH - Reproducibility of Results MH - *Athletic Performance/physiology MH - Male MH - Female MH - *Exercise Test/methods MH - Sex Factors MH - Young Adult MH - Time Factors MH - Adolescent MH - Biomechanical Phenomena OTO - NOTNLM OT - assessment OT - biomechanics OT - exercise training OT - force production EDAT- 2026/02/24 18:46 MHDA- 2026/05/01 12:37 CRDT- 2026/02/24 13:03 PHST- 2025/09/02 00:00 [received] PHST- 2025/12/11 00:00 [revised] PHST- 2026/01/06 00:00 [accepted] PHST- 2026/05/01 12:37 [medline] PHST- 2026/02/24 18:46 [pubmed] PHST- 2026/02/24 13:03 [entrez] AID - 10.1123/ijspp.2025-0203 [doi] PST - epublish SO - Int J Sports Physiol Perform. 2026 Feb 23;21(5):648-655. doi: 10.1123/ijspp.2025-0203. Print 2026 May 1. PMID- 41733776 OWN - NLM STAT- MEDLINE DCOM- 20260730 LR - 20260825 IS - 1573-7284 (Electronic) IS - 0393-2990 (Print) IS - 0393-2990 (Linking) VI - 41 IP - 6 DP - 2026 Jun TI - Associations between early-life mental health and abnormal sleep duration in midlife: findings from a prospective cohort study in Great Britain. PG - 789-798 LID - 10.1007/s10654-026-01366-6 [doi] AB - Good sleep quality is known to be associated with improved mental health, and vice-versa. However, the longitudinal association between mental health early in life and sleep later in life has not yet been rigorously investigated. The existence of such a relationship could imply that poor childhood mental health has lasting effects on sleep and, by extension, on physical health and mortality in the longer term. We used data from the 1970 British Cohort Study (N = 16 585). To operationalise childhood mental health, we separately analysed seven measures collected between the ages of 5 and 16. The outcome measures were self-reported, diary-derived and accelerometry-derived median nightly sleep duration at age 46. We conducted modified Poisson regression analyses with multiple imputation by chained equations. All seven measures of childhood mental health were positively associated with abnormal self-reported sleep duration. Five were associated with abnormal diary-derived estimates and four were associated with abnormal estimates from an accelerometry-based algorithm. Controlling for adult mental health symptoms post hoc attenuated the associations with self-reported sleep duration but not with the more objective estimates. This study provides clear evidence that poor mental health in childhood is associated with abnormal nightly sleep duration at age 46. Post-hoc analyses suggest that this effect might not be entirely mediated by mental health in adulthood. Presence of adult mental health symptoms may instead drive measurement error in self-reported sleep duration, and therefore result in biased estimates of the association with mental health earlier in life. CI - (c) 2026. The Author(s). FAU - Metherell, Thomas E AU - Metherell TE AUID- ORCID: 0000-0002-1770-7585 AD - Division of Psychology and Language Sciences, University College London, London, UK. thomas.metherell.22@ucl.ac.uk. AD - Centre for Longitudinal Studies, Social Research Institute, University College London, 20 Bedford Way, London, WC1H 0AL, UK. thomas.metherell.22@ucl.ac.uk. FAU - Ploubidis, George B AU - Ploubidis GB AUID- ORCID: 0000-0002-8198-5790 AD - Centre for Longitudinal Studies, Social Research Institute, University College London, 20 Bedford Way, London, WC1H 0AL, UK. FAU - Moreno-Agostino, Dario AU - Moreno-Agostino D AUID- ORCID: 0000-0003-0459-657X AD - Centre for Longitudinal Studies, Social Research Institute, University College London, 20 Bedford Way, London, WC1H 0AL, UK. AD - ESRC Centre for Society and Mental Health, King's College London, London, UK. LA - eng GR - 218497/Z/19/Z/WT_/Wellcome Trust/United Kingdom GR - ES/W013142/1/Economic and Social Research Council/ GR - 304283/Z/23/Z/WT_/Wellcome Trust/United Kingdom GR - WT_/Wellcome Trust/United Kingdom GR - ES/S012567/1/Economic and Social Research Council/ PT - Journal Article DEP - 20260224 PL - Netherlands TA - Eur J Epidemiol JT - European journal of epidemiology JID - 8508062 SB - IM MH - Humans MH - Female MH - United Kingdom/epidemiology MH - Sleep Duration MH - Male MH - *Mental Health MH - Prospective Studies MH - Accelerometry MH - Child MH - Child, Preschool MH - Self Report MH - Middle Aged MH - Adolescent MH - *Sleep Wake Disorders/epidemiology/psychology MH - *Sleep MH - Sleep Quality MH - Longitudinal Studies PMC - PMC7619131 MID - EMS214118 OTO - NOTNLM OT - Accelerometry OT - Childhood OT - Longitudinal OT - Mental health OT - Midlife OT - Risk factors OT - Sleep OT - Wellbeing COIS- Declarations. Competing interests: The authors have no relevant financial or non-financial interests to disclose. Ethical approval: Full details of the processes of ethical review and obtaining informed consent for BCS70 are available in a report published by the UCL Centre for Longitudinal Studies [56]. The most recent ethical approval was granted by the NHS London - Brighton & Sussex Research Ethics Committee in 2015. A separate ethical review was not required for this study. Informed consent was obtained from all research participants. Informed consent: Written informed consent was obtained from the parents. EDAT- 2026/02/24 18:45 MHDA- 2026/07/30 12:43 PMCR- 2026/02/24 CRDT- 2026/02/24 11:19 PHST- 2024/09/23 00:00 [received] PHST- 2026/01/12 00:00 [accepted] PHST- 2026/07/30 12:43 [medline] PHST- 2026/02/24 18:45 [pubmed] PHST- 2026/02/24 11:19 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - 10.1007/s10654-026-01366-6 [pii] AID - 1366 [pii] AID - 10.1007/s10654-026-01366-6 [doi] PST - ppublish SO - Eur J Epidemiol. 2026 Jun;41(6):789-798. doi: 10.1007/s10654-026-01366-6. Epub 2026 Feb 24. PMID- 41733754 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260710 IS - 1550-9397 (Electronic) IS - 1550-9389 (Print) IS - 1550-9389 (Linking) VI - 22 IP - 1 DP - 2026 Feb 24 TI - Initial validation of a pediatric cataplexy survey for children and adolescents with narcolepsy type 1. LID - 10.1007/s44470-026-00043-5 [doi] LID - 38 AB - PURPOSE: Cataplexy is core symptom of pediatric narcolepsy type 1 (NT1) but there is currently no validated cataplexy scale that captures the frequency, severity, and impact of cataplexy for children and adolescents to guide care. In this study, we developed and validated a 7-item Pediatric Cataplexy Scale (PCS). METHODS: We performed psychometric evaluation of the PCS using item response theory, specifically a graded response model (GRM). Sixty-nine children and adolescents with NT1 (age 9-21) from six North American sites completed the study. We examined the 7-item scale for internal consistency reliability (alpha, omega, marginal reliability), global and local model fit within the GRM framework, item discrimination and threshold ordering, convergent and divergent validity, and measurement invariance across sex. RESULTS: Internal consistency was strong using all three indicators. The freely estimated GRM provided superior fit over a Rasch-constrained model (p = 0.032) and excellent global fit indices (CFI = 0.996; TLI = 0.995; RMSEA = 0.041; SRMR = 0.041). Convergent validity was supported by significant correlations with the Narcolepsy Severity Scale (r = 0.459, p < 0.001) and the PedsQL Psychosocial Health Summary Score (r=-0.295, p = 0.014). Divergent validity was demonstrated through nonsignificant associations with the respiratory disturbance index and body mass index. Measurement invariance testing showed minimal non-invariance across sex, with no significant differences in latent means. CONCLUSION: The PCS shows desirable psychometric properties and can be used in clinical and research settings to assess cataplexy symptoms in NT1 youth. Current knowledge/Study rationale Cataplexy is a core symptom of pediatric narcolepsy type 1, yet no validated tool exists to measure its frequency, severity, and impact in children and adolescents. This gap limits clinicians' ability to assess symptom burden and guide treatment. Study impact In this study, we developed and validated the 7-item Pediatric Cataplexy Scale (PCS) using rigorous item response theory methods across a multi-site NT1 cohort. The PCS demonstrated strong internal consistency, excellent model fit, and appropriate convergent, divergent, and sex-invariant properties, supporting its reliability and validity. This scale offers the first psychometrically robust cataplexy measure to use in youth with NT1, enabling standardized symptom assessment in both clinical care and research. FAU - Maski, Kiran AU - Maski K AUID- ORCID: 0000-0003-4073-4036 AD - Department of Neurology, Boston Children's Hospital, Boston, MA, USA. kiran.maski@childrens.harvard.edu. FAU - Mignot, Emmanuel AU - Mignot E AD - Stanford Center for Sleep Sciences and Medicine, Redwood City, CA, USA. FAU - Wang, Grace Y AU - Wang GY AD - Department of Neurology, Boston Children's Hospital, Boston, MA, USA. FAU - Narang, Indra AU - Narang I AD - Division of Respiratory Medicine, Hospital for Sick Children, Toronto, ON, Canada. AD - Department of Pediatrics, University of Toronto, Toronto, ON, Canada. AD - Translational Medicine, Research Institute, The Hospital for Sick Children-SickKids, Toronto, ON, Canada. FAU - Worhach, Jennifer AU - Worhach J AD - Department of Neurology, Boston Children's Hospital, Boston, MA, USA. FAU - Strunc, Michael AU - Strunc M AD - Department of Neurology, Children's Hospital of the King's Daughter, Norfolk, VA, USA. FAU - Morse, Anne M AU - Morse AM AD - Department of Child Neurology and Pediatric Sleep Medicine, Janet Weis Children's Hospital, Geisinger Medical Center, Danville, PA, USA. FAU - Flygare, Julie AU - Flygare J AD - Project Sleep, Los Angeles, CA, USA. FAU - Sideridis, Georgios AU - Sideridis G AD - Biostatistics and Research Design Center, Boston Children's Hospital, Boston, MA, USA. FAU - Meltzer, Lisa J AU - Meltzer LJ AD - Department of Pediatrics, National Jewish Health, Denver, CO, USA. LA - eng GR - Wake Up Narcolepsy/Wake Up Narcolepsy/ GR - American Sleep Medicine Foundation/American Sleep Medicine Foundation/ PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20260224 PL - Switzerland TA - J Clin Sleep Med JT - Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine JID - 101231977 RN - Narcolepsy 1 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Child MH - *Narcolepsy/diagnosis/complications MH - Psychometrics MH - Reproducibility of Results MH - Surveys and Questionnaires MH - *Cataplexy/diagnosis MH - Young Adult MH - Severity of Illness Index PMC - PMC12994973 OTO - NOTNLM OT - Adolescent OT - Cataplexy OT - Children OT - Narcolepsy OT - Patient-reported outcomes OT - Pediatrics OT - Questionnaire OT - Survey OT - Validation OT - Youth COIS- Declarations. Ethics approval and consent to participate: The Boston Children's Hospital Institutional Review Board reviewed and approved study procedures (protocol number P00029346) and each site received their own IRB approval for data collection. The participating parent/guardian provided informed consent, and the child/adolescent participant gave their assent. Consent: All authors provide consent for publication. Competing Interests: Dr. Kiran Maski has been a consultant for Takeda Pharmaceuticals, Jazz Pharmaceuticals, Alkermes, Avadel, Eisai Pharmaceuticals, Synchronicity, Taysha Gene Therapies, and Harmony Biosciences. She has received research funding from Jazz Pharmaceuticals and Harmony Biosciences and is a collaborator for a clinical trial funded by Takeda Pharmaceuticals. Dr. Emmanuel Mignot has received research support from Apple, Jazz Pharmaceuticals, Takeda, Merck, GlaxoSmithKline, and Sunovion; is a consultant for Dreem, Alairion, Orexia, and Inexia; and is on the speakers' bureau for Vox Media. EDAT- 2026/02/24 18:46 MHDA- 2026/06/27 10:10 PMCR- 2027/02/24 CRDT- 2026/02/24 11:18 PHST- 2025/11/17 00:00 [received] PHST- 2026/01/06 00:00 [accepted] PHST- 2026/01/05 00:00 [revised] PHST- 2026/06/27 10:10 [medline] PHST- 2026/02/24 18:46 [pubmed] PHST- 2026/02/24 11:18 [entrez] PHST- 2027/02/24 00:00 [pmc-release] AID - 10.1007/s44470-026-00043-5 [pii] AID - 43 [pii] AID - 10.1007/s44470-026-00043-5 [doi] PST - epublish SO - J Clin Sleep Med. 2026 Feb 24;22(1):38. doi: 10.1007/s44470-026-00043-5. PMID- 41733140 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260708 IS - 1029-046X (Electronic) IS - 1026-776X (Linking) VI - 37 IP - 1 DP - 2026 Jan TI - Integrative network toxicology and molecular docking preliminarily explore the potential role of polystyrene microplastics in childhood obesity. PG - 1-21 LID - 10.1080/1062936X.2026.2629397 [doi] AB - Childhood obesity is a severe global epidemic, and emerging evidence suggests environmental pollutants like polystyrene microplastics (PS-MPs) may disrupt metabolic homoeostasis though mechanistic insights remain limited. This study integrated cross-species transcriptomics (from zebrafish and human adipose datasets), network toxicology, machine learning, and molecular docking to explore this link. We identified 40 overlapping genes between childhood obesity related DEGs and PS-MPs related genes, enriched in lipid metabolic pathways such as cholesterol homoeostasis and insulin signalling. Topological and machine-learning analyses highlighted hub genes, which showed strong diagnostic accuracy. Molecular docking further revealed stable binding (energy < -5.0 kcal/mol) between PS-MPs and key targets (APOB、BUB1、CDC20 and PPARGC1A). Our integrative analysis suggests that PS-MPs may act as an environmental trigger that could disrupt conserved lipid and metabolic homoeostasis by targeting key hub genes (APOB、BUB1、CDC20 and PPARGC1A). These findings provide a novel molecular hypothesis linking PS-MPs exposure to childhood obesity and support precautionary measures. FAU - Xiao, H AU - Xiao H AD - Institute of Maternal and Child Health, Wuhan Children' s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China. FAU - Huang, Y AU - Huang Y AD - Institute of Maternal and Child Health, Wuhan Children' s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China. FAU - Du, J AU - Du J AUID- ORCID: 0000-0003-2165-1112 AD - Institute of Maternal and Child Health, Wuhan Children' s Hospital (Wuhan Maternal and Child Healthcare Hospital), Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China. LA - eng PT - Journal Article DEP - 20260224 PL - England TA - SAR QSAR Environ Res JT - SAR and QSAR in environmental research JID - 9440156 RN - 0 (Polystyrenes) RN - 0 (Microplastics) RN - 0 (Environmental Pollutants) SB - IM MH - Humans MH - Animals MH - *Molecular Docking Simulation MH - *Polystyrenes/toxicity/chemistry MH - *Microplastics/toxicity/chemistry MH - Zebrafish MH - *Pediatric Obesity/chemically induced/genetics MH - *Environmental Pollutants/toxicity/chemistry MH - Transcriptome OTO - NOTNLM OT - Polystyrene microplastics OT - childhood obesity OT - lipid metabolism OT - molecular docking OT - network toxicology EDAT- 2026/02/24 18:46 MHDA- 2026/03/17 14:25 CRDT- 2026/02/24 07:04 PHST- 2026/03/17 14:25 [medline] PHST- 2026/02/24 18:46 [pubmed] PHST- 2026/02/24 07:04 [entrez] AID - 10.1080/1062936X.2026.2629397 [doi] PST - ppublish SO - SAR QSAR Environ Res. 2026 Jan;37(1):1-21. doi: 10.1080/1062936X.2026.2629397. Epub 2026 Feb 24. PMID- 41732741 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260224 LR - 20260813 IS - 2475-2991 (Electronic) IS - 2475-2991 (Linking) VI - 10 IP - 2 DP - 2026 Feb TI - Maternal Prenatal Psychosocial Stress in Relation to Maternal and Neonatal Anemia. PG - 107639 LID - 10.1016/j.cdnut.2026.107639 [doi] LID - 107639 AB - BACKGROUND: Maternal prenatal psychosocial stress and iron deficiency are both common, and each may affect fetal iron stores and subsequent offspring neurodevelopment. The extent to which psychosocial stress affects maternal iron status and maternal-fetal iron regulation is not known. OBJECTIVES: To assess 1) associations of prenatal stress and mental health with maternal anemia and neonatal hemoglobin (Hb), and 2) the extent to which prenatal stressors modify maternal anemia-neonatal Hb associations. METHODS: Observational data from participants enrolled in a randomized prenatal care trial were used. Prenatal distress, perceived stress, life stressors, and depression symptoms were assessed with validated questionnaires in the second (T2) and third trimesters (T3). T2 and T3 anemia (Hb <10.5 and 11 g/dL, respectively) and neonatal Hb were abstracted from participants' electronic health records. Adjusted log Poisson and linear regression models were fit. Effect measure modification was examined with stratified regression models and product terms. RESULTS: Hb was available for 1263 participants in T2, 1707 in T3, and 427 neonates <7 d old. Anemia prevalence was 27% in T2 and 51% in T3. Prenatal stressors were associated with higher rates of T3 but not T2 anemia: in models adjusted for the other stress exposures and covariates, T3 anemia was associated with perceived stress [prevalence ratio (PR): 1.02; 95% confidence interval (CI): 1.00,1.04] and 1-2 and >/=3 life stressors compared with none (PR:1.12; 95% CI 1.02, 1.26 and PR:1.2; 95% CI 1.02,1.41). Infants of mothers with T2 anemia had lower neonatal Hb (median: 16.6 g/dL, IQR: 15.3-18.5 compared with 17.2, 15.8-18.8; P = 0.077). Prenatal stressors were not associated with neonatal Hb, nor did they modify the relationship between maternal anemia and neonatal Hb. CONCLUSIONS: In this sample, maternal T3 anemia was sensitive to maternal stressors, whereas T2 anemia and neonatal Hb were not. Highly stress-exposed pregnancies may require additional monitoring and intervention for anemia to protect maternal and infant health. CI - (c) 2026 The Author(s). FAU - Campbell, Rebecca Kramer AU - Campbell RK AD - Division of Epidemiology and Biostatistics, University of Illinois Chicago School of Public Health, Chicago, IL, United States. FAU - Tsintsifas, Konstantina AU - Tsintsifas K AD - Division of Epidemiology and Biostatistics, University of Illinois Chicago School of Public Health, Chicago, IL, United States. FAU - Britt, Jessica AU - Britt J AD - Department of Obstetrics and Gynecology, Prisma Health, Greenville, SC, United States. FAU - Franklin, Andrew AU - Franklin A AD - Department of Pediatrics, Endeavor Health, Evanston, IL, United States. FAU - Miller, Gregory E AU - Miller GE AD - Institute for Policy Research, Northwestern University, Evanston, IL, United States. AD - Department of Psychology, Northwestern University, Evanston, IL, United States. FAU - Keenan-Devlin, Lauren AU - Keenan-Devlin L AD - Department of Obstetrics and Gynecology, Endeavor Health, Evanston, IL, United States. FAU - Borders, Ann AU - Borders A AD - Department of Obstetrics and Gynecology, Endeavor Health, Evanston, IL, United States. FAU - Crockett, Amy AU - Crockett A AD - Department of Obstetrics and Gynecology, Prisma Health, Greenville, SC, United States. LA - eng GR - P30 ES027792/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20260116 PL - United States TA - Curr Dev Nutr JT - Current developments in nutrition JID - 101717957 PMC - PMC12925089 OTO - NOTNLM OT - anemia OT - iron deficiency OT - iron regulation OT - maternal and child nutrition OT - neonate OT - nutrition OT - perinatal mental health OT - pregnancy OT - psychosocial stress COIS- The authors report no conflicts of interest. EDAT- 2026/02/24 13:00 MHDA- 2026/02/24 13:01 PMCR- 2026/01/16 CRDT- 2026/02/24 04:19 PHST- 2025/11/06 00:00 [received] PHST- 2026/01/06 00:00 [revised] PHST- 2026/01/08 00:00 [accepted] PHST- 2026/02/24 13:01 [medline] PHST- 2026/02/24 13:00 [pubmed] PHST- 2026/02/24 04:19 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - S2475-2991(26)00004-1 [pii] AID - 107639 [pii] AID - 10.1016/j.cdnut.2026.107639 [doi] PST - epublish SO - Curr Dev Nutr. 2026 Jan 16;10(2):107639. doi: 10.1016/j.cdnut.2026.107639. eCollection 2026 Feb. PMID- 41732438 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260224 LR - 20260813 IS - 2451-8654 (Electronic) IS - 2451-8654 (Linking) VI - 50 DP - 2026 Apr TI - The efficacy of home-based virtual reality exposure therapy as an add-on to behavioral therapy for children with selective mutism: Protocol for a single-case experimental design. PG - 101602 LID - 10.1016/j.conctc.2026.101602 [doi] LID - 101602 AB - BACKGROUND: Selective Mutism (SM) is a rare childhood anxiety disorder characterized by an inability to speak in specific social situations, despite speaking freely in others. School is typically the environment where the disorder manifests itself most clearly. Children with SM often have difficulty generalizing speaking across different social situations. Parents and teachers often struggle to practice speaking with the child outside of therapy due to practical reasons and time constraints. Virtual Reality Exposure Therapy (VRET) at home has potential to enhance the treatment of SM by providing an alternative and engaging method for delivering exercises that support behavioral treatment. METHODS: This paper describes the development of the VRET application Speaking at School-VR and the methodology of the single case experimental design (SCED) to evaluate the feasibility and preliminary effects of the behavioral treatment at school, complemented with VRET at home, for children with SM, aged 4-13. A secondary aim is to evaluate the feasibility and adherence of home-based VRET based on qualitative information to capture participants' experiences. A total of 15 children with SM and their families will be enrolled in the study to examine the potential effectiveness of the combined treatment. The treatment consists of 10 behavioral steps, each accompanied by complementary VRET exercises. CONCLUSION: This is the first study to examine the feasibility and the potential effectiveness of home-delivered VRET as an adjunct to behavioral treatment for children with SM. The addition of VRET to behavioral treatment has the potential to enhance the generalization and transfer of skills across different situations in a facilitative and engaging way. CI - (c) 2026 The Authors. FAU - van Vlerken, Wendy AU - van Vlerken W AD - Amsterdam UMC, University of Amsterdam, Department of Child and Adolescent Psychiatry, Amsterdam Public Health, the Netherlands. AD - Academic Center for Child and Adolescent Psychiatry Levvel, Amsterdam, the Netherlands. FAU - Legerstee, Jeroen S AU - Legerstee JS AD - Academic Center for Child and Adolescent Psychiatry Levvel, Amsterdam, the Netherlands. AD - Research Institute of Child Development and Education, University of Amsterdam, the Netherlands. FAU - Belleman, Robert G AU - Belleman RG AD - Informatics Institute, University of Amsterdam, the Netherlands. FAU - Bouwmeester, Samantha AU - Bouwmeester S AD - Out of the Boxplot, Rotterdam, the Netherlands. FAU - Meester, Lynn F AU - Meester LF AD - Academic Center for Child and Adolescent Psychiatry Levvel, Amsterdam, the Netherlands. FAU - Roorda, Annelot AU - Roorda A AD - Academic Center for Child and Adolescent Psychiatry Levvel, Amsterdam, the Netherlands. FAU - Lindauer, Ramon J L AU - Lindauer RJL AD - Amsterdam UMC, University of Amsterdam, Department of Child and Adolescent Psychiatry, Amsterdam Public Health, the Netherlands. AD - Academic Center for Child and Adolescent Psychiatry Levvel, Amsterdam, the Netherlands. FAU - Utens, Elisabeth M W J AU - Utens EMWJ AD - Amsterdam UMC, University of Amsterdam, Department of Child and Adolescent Psychiatry, Amsterdam Public Health, the Netherlands. AD - Academic Center for Child and Adolescent Psychiatry Levvel, Amsterdam, the Netherlands. AD - Research Institute of Child Development and Education, University of Amsterdam, the Netherlands. FAU - Stapersma, Luuk AU - Stapersma L AD - Amsterdam UMC, University of Amsterdam, Department of Child and Adolescent Psychiatry, Amsterdam Public Health, the Netherlands. AD - Academic Center for Child and Adolescent Psychiatry Levvel, Amsterdam, the Netherlands. LA - eng PT - Journal Article DEP - 20260116 PL - Netherlands TA - Contemp Clin Trials Commun JT - Contemporary clinical trials communications JID - 101671157 PMC - PMC12925134 OTO - NOTNLM OT - Anxiety disorder OT - Children OT - Exposure therapy OT - Selective mutism OT - Virtual reality COIS- The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/02/24 06:32 MHDA- 2026/02/24 06:33 PMCR- 2026/01/16 CRDT- 2026/02/24 04:16 PHST- 2025/06/30 00:00 [received] PHST- 2026/01/10 00:00 [revised] PHST- 2026/01/16 00:00 [accepted] PHST- 2026/02/24 06:33 [medline] PHST- 2026/02/24 06:32 [pubmed] PHST- 2026/02/24 04:16 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - S2451-8654(26)00009-8 [pii] AID - 101602 [pii] AID - 10.1016/j.conctc.2026.101602 [doi] PST - epublish SO - Contemp Clin Trials Commun. 2026 Jan 16;50:101602. doi: 10.1016/j.conctc.2026.101602. eCollection 2026 Apr. PMID- 41731940 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1477-1128 (Electronic) IS - 1463-4236 (Print) IS - 1463-4236 (Linking) VI - 27 DP - 2026 Feb 24 TI - Adaptation of the mothers' breastfeeding empowerment scale to Turkish society. PG - e26 LID - 10.1017/S1463423626100863 [doi] LID - e26 AB - AIM: 'It was aimed to establish the validity and reliability of the "Mothers' Breastfeeding Empowerment Scale"'. METHOD: Content validity was evaluated with the content validity index (CVI) agreed upon by experts. Exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were used for construct validity. Before factor analysis, the sample size was decided using KMO and Bartlett's Sphericity test. For the reliability study of the scale, Cronbach's Alpha coefficient and total score correlation coefficients of parallel forms were examined. RESULTS: While 49.9% of the infants were between 4-6 months old, the average age of the infants was determined as 3.64 +/- 1.77. 70.6% of the mothers were between the ages of 26-43 and the average age of the mothers was 28.83 +/- 5.38. In the factor analysis it was found that item loadings of the scale was between 0.57 and 0.95. Also, the fit values of the scale were within acceptable limits. Additionally, it was determined that there was a high-level positive relationship between the scale used for the parallel form and our scale. CONCLUSION: The use of the scale in Turkish society is valid and reliable. Validity and reliability analyses support this. FAU - Cigdem, Zerrin AU - Cigdem Z AUID- ORCID: 0000-0002-2527-5700 AD - Faculty of Health Sciences, Istanbul TopkapI Universitesi, Turkiye. FAU - Kaya, Leyla AU - Kaya L AUID- ORCID: 0000-0002-2199-0854 AD - Faculty of Health Sciences, Health Sciences University, Turkiye. FAU - Yavas Celik, Melike AU - Yavas Celik M AUID- ORCID: 0000-0002-1155-1022 AD - Faculty of Health Sciences, https://ror.org/020vvc407Gaziantep University, Gaziantep, Turkiye. LA - eng PT - Journal Article PT - Validation Study DEP - 20260224 PL - England TA - Prim Health Care Res Dev JT - Primary health care research & development JID - 100897390 SB - IM MH - Humans MH - Turkey MH - *Breast Feeding/psychology MH - Female MH - Reproducibility of Results MH - *Mothers/psychology MH - Psychometrics MH - Adult MH - Surveys and Questionnaires/standards MH - Factor Analysis, Statistical MH - *Empowerment MH - Infant PMC - PMC12951330 OTO - NOTNLM OT - breastfeeding OT - psychometric measurement OT - validity and reliability COIS- The authors report no actual or potential conflicts of interest. EDAT- 2026/02/24 06:33 MHDA- 2026/02/24 06:34 PMCR- 2026/02/24 CRDT- 2026/02/24 01:33 PHST- 2026/02/24 06:34 [medline] PHST- 2026/02/24 06:33 [pubmed] PHST- 2026/02/24 01:33 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - S1463423626100863 [pii] AID - 10.1017/S1463423626100863 [doi] PST - epublish SO - Prim Health Care Res Dev. 2026 Feb 24;27:e26. doi: 10.1017/S1463423626100863. PMID- 41731444 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Feb 23 TI - The mediating role of physical activity enjoyment in the relationship between physical activity and subjective well-being among adolescents. LID - 10.1186/s12889-026-26676-y [doi] LID - 1051 AB - BACKGROUND: Physical activity (PA) has been associated with subjective well-being (SWB) among adolescents. However, the processes underlying this association, particularly the role of physical activity enjoyment (PAE) in PA, have been less explored. This study aimed to examine the associations among PA, PAE, and SWB among Chinese adolescents. METHODS: A cross-sectional study was conducted among 947 students recruited from two junior high school and two senior high schools in a city in Shanxi Province, China. Participants completed validated questionnaires assessing PA, PAE, and SWB. Using the SPSS macro PROCESS, a mediation model was tested with PA as the independent variable, SWB as the dependent variable, and PAE as the mediator while controlling for gender and grade. The bootstrap method was employed to examine the significance of the mediating effect. RESULTS: Mediation analysis revealed that PA was a significant positive predictor of both PAE (beta = 0.529, P < 0.001) and SWB (beta = 0.147, P < 0.001). However, when PAE was included in the model, the direct effect of PA on SWB became nonsignificant. Bootstrap results (based on 5000 samples) confirmed that the direct effect was not significant (beta = -0.010, 95% CI [-0.039, 0.031]), whereas the indirect effect through PAE was significant (beta = 0.157, 95% CI [0.110, 0.209]). CONCLUSION: PAE mediates the relationship between PA and SWB in adolescents. These findings highlight the potential importance of promoting enjoyable PA experiences to support adolescent well-being. FAU - Peng, Jiale AU - Peng J AD - School of Physical Education, Guangdong University of Education, Guangzhou, 510303, China. AD - School of Sport Science, Beijing Sport University, Beijing, 100084, China. FAU - Yu, Wenlang AU - Yu W AD - School of Sport Science, Beijing Sport University, Beijing, 100084, China. FAU - Yan, Wenjing AU - Yan W AD - Shanxi Normal University, Taiyuan, Shanxi, 030031, China. FAU - Zheng, Bin AU - Zheng B AD - General Hospital of Northern Theater Command, Shenyang, 110003, China. xyxxzb@126.com. LA - eng GR - 2024JH2/102600270/Liaoning Provincial Science and Technology Plan Joint Program (Technology Research and Development Project)/ PT - Journal Article DEP - 20260223 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - *Psychological Well-Being MH - Male MH - Cross-Sectional Studies MH - Female MH - *Exercise/psychology MH - China MH - Surveys and Questionnaires MH - *Pleasure PMC - PMC13036990 OTO - NOTNLM OT - Adolescents OT - Enjoyment of physical activity OT - Physical activity OT - Subjective well-being COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki. The study was approved by the Ethics Committee for Sports Science Experiments of Beijing Sport University (Approval No. 2020128 H). Informed consent to participate was obtained from the parents or legal guardians through the school administration prior to data collection. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/24 00:30 MHDA- 2026/06/27 12:36 PMCR- 2026/02/23 CRDT- 2026/02/23 23:57 PHST- 2025/10/06 00:00 [received] PHST- 2026/02/11 00:00 [accepted] PHST- 2026/06/27 12:36 [medline] PHST- 2026/02/24 00:30 [pubmed] PHST- 2026/02/23 23:57 [entrez] PHST- 2026/02/23 00:00 [pmc-release] AID - 10.1186/s12889-026-26676-y [pii] AID - 26676 [pii] AID - 10.1186/s12889-026-26676-y [doi] PST - epublish SO - BMC Public Health. 2026 Feb 23;26(1):1051. doi: 10.1186/s12889-026-26676-y. PMID- 41731165 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1437-1596 (Electronic) IS - 0937-9827 (Print) IS - 0937-9827 (Linking) VI - 140 IP - 4 DP - 2026 Jul TI - Assessment of periodontal ligament visibility in third molars for threshold-based forensic age estimation: a cross-sectional study in a Turkish population. PG - 2175-2182 LID - 10.1007/s00414-026-03753-w [doi] AB - OBJECTIVES: Forensic age estimation in living individuals is particularly challenging near legally relevant age thresholds after dental maturation is complete. This study aimed to evaluate the applicability of periodontal ligament (PDL) visibility staging in third molars as a post-maturation marker for threshold-based forensic age estimation, with specific focus on the 21-year age cut-off, in a Turkish population. MATERIALS AND METHODS: A retrospective analysis was conducted on 1,049 digital orthopantomograms (OPGs) of individuals aged 15-25 years. PDL visibility in maxillary and mandibular third molars was assessed according to the Olze et al. staging system. Associations between PDL stages, chronological age, sex, and tooth position were analyzed. Diagnostic performance for identifying individuals aged >/= 21 years was evaluated using receiver operating characteristic (ROC) analysis. RESULTS: Advanced PDL visibility stages were significantly associated with increasing age. Mandibular third molars provided the most informative staging patterns. ROC analysis demonstrated good discriminative accuracy for the 21-year threshold, with an area under the curve (AUC) of 0.79, indicating balanced sensitivity and specificity for threshold-based classification. Substantial intra- and inter-observer agreement confirmed methodological reliability. CONCLUSIONS: PDL visibility staging in third molars represents a reliable and reproducible complementary tool for forensic age estimation around the 21-year threshold in a Turkish population. Rather than exact age prediction, this method supports probabilistic decision-making in legally relevant age assessment and may contribute to a multimodal forensic age estimation framework. FAU - Ergin, Mehmet Oguzhan AU - Ergin MO AUID- ORCID: 0000-0003-3216-9698 AD - Department of Periodontology, Faculty of Dentistry, Harran University, Sanliurfa, Turkey. dtoguzhanergin@gmail.com. FAU - Erciyas, Kamile AU - Erciyas K AD - Department of Periodontology, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey. FAU - Gunes, Sevim Samioglu AU - Gunes SS AD - Department of Periodontology, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey. FAU - Isir, Aysun Baransel AU - Isir AB AD - Department of Forensic Medicine, Faculty of Medicine, Gaziantep University, Gaziantep, Turkey. LA - eng PT - Journal Article DEP - 20260224 PL - Germany TA - Int J Legal Med JT - International journal of legal medicine JID - 9101456 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - *Molar, Third/diagnostic imaging/growth & development MH - *Periodontal Ligament/diagnostic imaging/growth & development MH - Adolescent MH - Adult MH - Young Adult MH - Female MH - Turkey MH - Male MH - Radiography, Panoramic MH - Retrospective Studies MH - Cross-Sectional Studies MH - ROC Curve MH - Radiography, Dental, Digital MH - Sensitivity and Specificity MH - Reproducibility of Results PMC - PMC13275604 OTO - NOTNLM OT - Age estimation OT - Forensic dentistry OT - Panoramic radiography OT - Periodontal ligament OT - Third molars COIS- Declarations. Ethics approval: was obtained from the Gaziantep University Clinical Research Ethics Committee (Decision No.: 2024/94, dated 27 March 2024). The study was conducted in accordance with the Declaration of Helsinki (2013 revision). Consent for publication: Not applicable. Consent to participate: Due to the retrospective nature of the study and the use of anonymized radiographic data, informed consent to participate was waived by the Ethics Committee. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/02/24 00:29 MHDA- 2026/06/28 00:36 PMCR- 2026/02/24 CRDT- 2026/02/23 23:26 PHST- 2026/01/01 00:00 [received] PHST- 2026/02/13 00:00 [accepted] PHST- 2026/06/28 00:36 [medline] PHST- 2026/02/24 00:29 [pubmed] PHST- 2026/02/23 23:26 [entrez] PHST- 2026/02/24 00:00 [pmc-release] AID - 10.1007/s00414-026-03753-w [pii] AID - 3753 [pii] AID - 10.1007/s00414-026-03753-w [doi] PST - ppublish SO - Int J Legal Med. 2026 Jul;140(4):2175-2182. doi: 10.1007/s00414-026-03753-w. Epub 2026 Feb 24. PMID- 41729882 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260901 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 2 DP - 2026 TI - Independent validation of circulating microRNAs as biomarkers in a case-control study of adolescents with type 1 diabetes for more than 8 years. PG - e0343117 LID - 10.1371/journal.pone.0343117 [doi] LID - e0343117 AB - MicroRNAs (miRNAs) are epigenetic regulators of gene activity. Analysis of circulating miRNAs enables minimal-invasive studies of disease mechanisms and identification of novel disease biomarkers. The aim of this case-control validation study was to investigate previously identified circulating miRNAs in Swedish adolescents with long-duration (8.0-16.5 years) type 1 diabetes (T1D), and healthy matched controls to confirm their utility as biomarker candidates to diagnose and monitor the progression of T1D. Quantitative PCR analysis of 23 previously reported miRNAs was performed in 24 T1D and 24 control individuals. Body composition was assessed by dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. Prospectively collected clinical data were retrieved from the Swedish diabetes quality registry. The selected miRNAs showed higher variability in both male and female T1D groups compared to controls. Statistical analysis confirmed differences for 12 miRNAs in comparison with controls, including miR-223-3p and miR-135a-5p, which previously were reported to be associated with T1D. MiR-34a-5p and miR-210-3p were positively associated with T1D duration and HbA1c (average from the last year), respectively. In conclusion, 12 previously reported miRNAs showed consistent differential expression between individuals with T1D and controls. Among these were miR-223-3p and miR-135a-5p, which are associated with cardiovascular/inflammatory disease and cancer, respectively. These findings suggest potential clinical utility of circulating miRNAs for T1D diagnosis and disease monitoring, although extended validation of the identified miRNA biomarkers in larger, independent cohorts is required to establish the necessary scientific evidence for clinical translation. CI - Copyright: (c) 2026 Swolin-Eide et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Swolin-Eide, Diana AU - Swolin-Eide D AD - Department of Pediatrics, Institute for Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Department of Pediatrics, Sahlgrenska University Hospital, Gothenburg, Region Vastra Gotaland, Sweden. FAU - Pundziute Lycka, Auste AU - Pundziute Lycka A AD - Department of Pediatrics, Institute for Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Department of Pediatrics, Sahlgrenska University Hospital, Gothenburg, Region Vastra Gotaland, Sweden. FAU - Forsander, Gun AU - Forsander G AD - Department of Pediatrics, Institute for Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. FAU - Novak, Daniel AU - Novak D AD - Department of Pediatrics, Institute for Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. AD - Department of Pediatrics, Sahlgrenska University Hospital, Gothenburg, Region Vastra Gotaland, Sweden. FAU - Grillari, Johannes AU - Grillari J AUID- ORCID: 0000-0001-5474-6332 AD - Ludwig Boltzmann Institute for Traumatology, Research Center in cooperation with AUVA, Vienna, Austria. AD - Austrian Cluster for Tissue Regeneration, Vienna, Austria. AD - Institute of Molecular Biotechnology, BOKU - University, Vienna, Austria. FAU - Diendorfer, Andreas B AU - Diendorfer AB AD - TAmiRNA GmbH, Vienna, Austria. FAU - Hackl, Matthias AU - Hackl M AD - Austrian Cluster for Tissue Regeneration, Vienna, Austria. AD - TAmiRNA GmbH, Vienna, Austria. FAU - Magnusson, Per AU - Magnusson P AUID- ORCID: 0000-0002-2123-7838 AD - Department of Biomedical and Clinical Sciences, Linkoping University, Linkoping, Sweden. AD - Department of Clinical Chemistry, Region Ostergotland, Linkoping, Sweden. LA - eng PT - Journal Article PT - Validation Study DEP - 20260223 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Biomarkers) RN - 0 (Circulating MicroRNA) RN - 0 (hemoglobin A1c protein, human) RN - 0 (Glycated Hemoglobin) SB - IM MH - Biomarkers/blood MH - *Circulating MicroRNA/blood/genetics/metabolism MH - *Diabetes Mellitus, Type 1/blood/diagnosis/genetics MH - Case-Control Studies MH - Sweden MH - Healthy Volunteers MH - Prospective Studies MH - Humans MH - Male MH - Female MH - Adolescent MH - Glycated Hemoglobin/analysis MH - Gene Expression Regulation PMC - PMC12928441 COIS- Dr Andreas B. Diendorfer and Dr Matthias Hackl are employed by TAmiRNA GmbH. Dr Johannes Grillari and Dr Matthias Hackl are shareholders of TAmiRNA and hold IP in relation to the diagnostic use of circulating miRNAs. The authors declare that there are no other relationships or activities that might bias, or be perceived to bias, their work. EDAT- 2026/02/23 18:52 MHDA- 2026/02/23 18:53 PMCR- 2026/02/23 CRDT- 2026/02/23 13:34 PHST- 2025/11/19 00:00 [received] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/02/23 18:53 [medline] PHST- 2026/02/23 18:52 [pubmed] PHST- 2026/02/23 13:34 [entrez] PHST- 2026/02/23 00:00 [pmc-release] AID - PONE-D-25-60845 [pii] AID - 10.1371/journal.pone.0343117 [doi] PST - epublish SO - PLoS One. 2026 Feb 23;21(2):e0343117. doi: 10.1371/journal.pone.0343117. eCollection 2026. PMID- 41729314 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1591-9528 (Electronic) IS - 1591-8890 (Print) IS - 1591-8890 (Linking) VI - 26 IP - 1 DP - 2026 Feb 23 TI - Early detection and risk stratification of insulin resistance in children and adolescents with excess weight: a sdLDL/oxLDL-Based model. LID - 10.1007/s10238-026-02089-4 [doi] LID - 163 AB - Childhood excess weight is a significant risk factor for insulin resistance (IR), a key precursor to metabolic syndrome and type 2 diabetes. In epidemiologic studies, IR is commonly assessed by the homeostatic model assessment for insulin resistance (HOMA-IR). This study aimed to develop a small dense low-density lipoprotein (sdLDL) and oxidized low-density lipoprotein (oxLDL)-based model for the early detection and risk stratification of HOMA-IR-defined IR in children and adolescents with excess weight. A total of 510 children and adolescents with excess weight (aged 7-17 years) were enrolled and stratified into IR (n = 173) and non-IR (n = 337) groups according to HOMA-IR. Comprehensive anthropometric and biochemical parameters were collected, including comparative analyses of sdLDL, oxLDL, and triglyceride to high-density lipoprotein cholesterol (TG/HDL) ratio. Independent risk factors were identified through univariate and multivariate logistic regression, followed by development of a nomogram prediction model incorporating three lipid parameters and adjusted for age and sex. Model performance was evaluated using receiver operating characteristic curves, calibration analysis with bootstrap internal validation and decision curve analysis (DCA). Univariate analysis identified significant associations between IR and mean arterial pressure, TG/HDL, total cholesterol to HDL (TC/HDL) ratio, LDL to HDL (LDL/HDL) ratio, oxLDL, and sdLDL (all P < 0.05). Multivariate analysis confirmed TG/HDL (adjusted odds ratio [aOR] = 5.61, 95% confidence interval [CI]: 3.060-10.639, P < 0.001), oxLDL (aOR = 1.092, 95% CI: 1.065-1.120, P < 0.001), and sdLDL (aOR = 1.109, 95% CI: 1.076-1.146, P < 0.001) as independent risk factors. The final age- and sex-adjusted nomogram demonstrated strong discrimination (AUC = 0.836), good calibration (bootstrap-corrected mean absolute error = 0.012), and clear net clinical benefit across a wide range of decision thresholds based on DCA. Probability-based stratification enabled both continuous scoring and visual classification of individual IR risk. The developed age- and sex-adjusted nomogram combining TG/HDL ratio, sdLDL, and oxLDL demonstrates superior performance for predicting IR in children and adolescents with excess weight. By integrating continuous risk scoring with clinically actionable risk stratification, this tool supports early identification and tiered management in both screening and clinical decision-making settings. CI - (c) 2026. The Author(s). FAU - Zhao, YaJie AU - Zhao Y AD - School of Medical Laboratory Technology, Xinyang Vocational and Technical College, No.48, New 24th Street, Pingqiao District, Xinyang City, 464000, Henan Province, China. FAU - Zhu, ZhaoYu AU - Zhu Z AD - School of Medical Laboratory Technology, Xinyang Vocational and Technical College, No.48, New 24th Street, Pingqiao District, Xinyang City, 464000, Henan Province, China. FAU - Hu, WenTan AU - Hu W AD - Department of Clinical Laboratory, Xinyang Central Hospital, Xinyang City, 464000, Henan Province, China. FAU - Li, Ju AU - Li J AD - School of Medical Laboratory Technology, Xinyang Vocational and Technical College, No.48, New 24th Street, Pingqiao District, Xinyang City, 464000, Henan Province, China. zyjliju@hotmail.com. LA - eng PT - Journal Article DEP - 20260223 PL - Italy TA - Clin Exp Med JT - Clinical and experimental medicine JID - 100973405 RN - 0 (Lipoproteins, LDL) RN - 0 (oxidized low density lipoprotein) SB - IM MH - Humans MH - *Lipoproteins, LDL/blood MH - Child MH - Adolescent MH - Female MH - *Insulin Resistance MH - Male MH - Early Diagnosis MH - Risk Factors MH - Risk Assessment MH - ROC Curve MH - *Overweight/complications PMC - PMC12932282 OTO - NOTNLM OT - Insulin resistance OT - Lipid metabolism OT - OxLDL OT - Pediatric obesity OT - Risk stratification OT - SdLDL OT - TG/HDL ratio COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval: The present study was approved by the Ethics Committee of Xinyang Central Hospital (No.202103XY66) and written informed consent was provided by all parents or guardians of the patients prior to the study start. All procedures were performed in accordance with the ethical standards of the Institutional Review Board and The Declaration of Helsinki, and its later amendments or comparable ethical standards. EDAT- 2026/02/23 13:06 MHDA- 2026/02/26 06:58 PMCR- 2026/02/23 CRDT- 2026/02/23 11:16 PHST- 2025/07/30 00:00 [received] PHST- 2026/02/03 00:00 [accepted] PHST- 2026/02/26 06:58 [medline] PHST- 2026/02/23 13:06 [pubmed] PHST- 2026/02/23 11:16 [entrez] PHST- 2026/02/23 00:00 [pmc-release] AID - 10.1007/s10238-026-02089-4 [pii] AID - 2089 [pii] AID - 10.1007/s10238-026-02089-4 [doi] PST - epublish SO - Clin Exp Med. 2026 Feb 23;26(1):163. doi: 10.1007/s10238-026-02089-4. PMID- 41729050 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1473-5571 (Electronic) IS - 0269-9370 (Print) IS - 0269-9370 (Linking) VI - 40 IP - 5 DP - 2026 May 1 TI - Breastfeeding support for women with HIV: lactation consultant HIV-knowledge, attitudes, stigma, and tele-lactation experiences. PG - 547-557 LID - 10.1097/QAD.0000000000004466 [doi] AB - OBJECTIVES: To characterize lactation consultants' (LCs) HIV-related knowledge, attitudes, stigma, and tele-lactation experience relevant to supporting pregnant and postpartum people with HIV (PP-PWH). DESIGN: Cross-sectional mixed-methods study of lactation consultants. METHODS: We conducted a mixed-methods survey of certified LCs in the United States and Canada. Quantitative measures assessed general HIV knowledge, HIV breastfeeding-specific knowledge, attitudes toward breastfeeding among PP-PWH, HIV-related stigma, and tele-lactation experience using validated instruments. Multivariable regression models examined associations between provider characteristics, knowledge, stigma, and attitudes. Qualitative free-text responses were analyzed thematically using the Health Stigma and Discrimination Framework, with findings integrated to contextualize quantitative results. RESULTS: The sample included 207 internationally certified LCs, most of whom reported no or limited clinical experience supporting PP-PWH. General HIV knowledge was high, while HIV-specific breastfeeding knowledge was moderate. Higher HIV-specific knowledge was independently associated with prior experience supporting PP-PWH and awareness of updated infant-feeding recommendations, whereas years in practice and general HIV knowledge were not. HIV-related stigma levels were generally low; lower stigma was associated with greater support for patient autonomy but more cautious endorsement of breastfeeding in high-resource settings. Tele-lactation experience was common. Qualitative findings emphasized strong support for patient autonomy and nonjudgmental, informed counseling, alongside high willingness to learn and engage in additional training to better support PP-PWH. CONCLUSIONS: LCs are motivated to support PP-PWH but face HIV-specific knowledge gaps and structural challenges shaping preparedness and counseling practices. Targeted education, clear guidance, and integration of tele-lactation within HIV care systems may strengthen equitable, person-centered lactation support. CI - Copyright (c) 2026 The Author(s). Published by Wolters Kluwer Health, Inc. FAU - Barr, Emily Anne AU - Barr EA AD - Department of Research, Cizik School of Nursing, University of Texas Health Sciences Center. FAU - Abuogi, Lisa AU - Abuogi L AD - University at Buffalo School of Nursing, Buffalo, NY. FAU - Lingwall, Mary AU - Lingwall M AD - Department of Research, Cizik School of Nursing, University of Texas Health Sciences Center. FAU - Qian, Qian AU - Qian Q AD - Department of Biostatistics & Data Science, School of Public Health, University of Texas Health Sciences Center. FAU - Anthony, Leah AU - Anthony L AD - Department of Research, Cizik School of Nursing, University of Texas Health Sciences Center. FAU - Vennekotter, Joanna AU - Vennekotter J AD - Department of Research, Cizik School of Nursing, University of Texas Health Sciences Center. FAU - Lowenthal, Elizabeth D AU - Lowenthal ED AD - Department of Graduate Studies, Cizik School of Nursing, University of Texas Health Sciences Center. FAU - Wu, Hulin AU - Wu H AD - Department of Biostatistics & Data Science, School of Public Health, University of Texas Health Sciences Center. FAU - Zhang, Tianheng AU - Zhang T AD - Department of Biostatistics & Data Science, School of Public Health, University of Texas Health Sciences Center. FAU - Tsusaki, Rebecca AU - Tsusaki R AD - Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO. FAU - McKinney, Jennifer R AU - McKinney JR AD - Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Baylor College of Medicine, Houston, TX, USA. LA - eng GR - K24 AI175015/AI/NIAID NIH HHS/United States PT - Journal Article DEP - 20260316 PL - England TA - AIDS JT - AIDS (London, England) JID - 8710219 SB - IM MH - Humans MH - Female MH - *Breast Feeding/psychology MH - *HIV Infections/psychology MH - Cross-Sectional Studies MH - *Health Knowledge, Attitudes, Practice MH - Adult MH - Canada MH - United States MH - *Social Stigma MH - Middle Aged MH - Lactation MH - Surveys and Questionnaires MH - Pregnancy MH - *Consultants/psychology MH - Male PMC - PMC13034739 OTO - NOTNLM OT - HIV OT - breastfeeding OT - chestfeeding OT - infant feeding OT - lactation consultants OT - perinatal HIV transmission OT - stigma OT - telehealth OT - women and HIV COIS- The authors have no competing interests to disclose or financial disclosures to declare. EDAT- 2026/02/23 13:06 MHDA- 2026/03/27 17:38 PMCR- 2026/03/30 CRDT- 2026/02/23 09:33 PHST- 2025/08/22 00:00 [received] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/03/27 17:38 [medline] PHST- 2026/02/23 13:06 [pubmed] PHST- 2026/02/23 09:33 [entrez] PHST- 2026/03/30 00:00 [pmc-release] AID - 00002030-990000000-00869 [pii] AID - AIDS-D-25-00454 [pii] AID - 10.1097/QAD.0000000000004466 [doi] PST - ppublish SO - AIDS. 2026 May 1;40(5):547-557. doi: 10.1097/QAD.0000000000004466. Epub 2026 Mar 16. PMID- 41728575 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260223 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 1 DP - 2026 Jan TI - A Prospective Clinical Evaluation of the Retention of Glass Ionomer Cement Versus Resin-Based Pit and Fissure Sealants Among School Children. PG - e102037 LID - 10.7759/cureus.102037 [doi] LID - e102037 AB - Introduction Dental caries are commonly observed in schoolchildren, particularly on the complex pit and fissure surfaces of permanent molars, which readily trap plaque and debris, making sealants a critical preventive intervention. This prospective comparative clinical study sought to assess the retention rates and clinical performance of glass ionomer cement (GIC) and resin-based sealants in a school-based setting among children aged 7-10 years. Materials and methods This study was carried out in government primary schools in Bhopal, India, from June to December 2024. Eighty children with at least one caries-free permanent first molar were non-randomly assigned to two groups (n = 40 per group). Group 1 received a high-viscosity glass ionomer cement (GIC) sealant (Fuji IX GP; GC Corp., Tokyo, Japan), applied using the press-finger technique following polyacrylic acid conditioning. Group 2 received a light-cured, fluoride-releasing resin-based sealant (Clinpro; 3M ESPE, 3M Company, St. Paul, MN), applied after phosphoric acid etching. Sealants were placed by a single operator using a portable device. Retention was evaluated at five months using a custom three-point scoring system (complete, partial, or complete loss), with high intra- and inter-examiner reliability (kappa >/=0.85). Data were analyzed using Chi-square, Mann-Whitney U, and Kaplan-Meier survival tests (p<0.05). Results Resin-based sealants showed significantly higher retention, with 38% complete retention compared with 26% for GIC, and lower failure rates (13% versus 24%; p = 0.031). Survival analysis demonstrated greater longevity of resin-based materials, with fissure sites performing better than pits (p = 0.001). Twice-daily toothbrushing was associated with better sealant retention (p = 0.021). No significant differences were found with respect to age, sex, or diet. Conclusions Resin-based sealants demonstrated superior short-term retention and durability compared with GIC in schoolchildren. The choice of material should take into account the clinical setting and patient-related factors to optimize caries prevention. CI - Copyright (c) 2026, Ghosh et al. FAU - Ghosh, Debadrita AU - Ghosh D AD - Department of Pedodontics and Preventive Dentistry, Family Dental Clinic, Kolkata, IND. FAU - Shivanand, Sunita AU - Shivanand S AD - Department of Conservative Dentistry and Endodontics, KLE Vishwanath Katti Institute of Dental Sciences and Hospital, Belagavi, IND. FAU - Tiwari, Piyushi AU - Tiwari P AD - Department of Conservative Dentistry and Endodontics, RKDF Dental College and Research Centre, Bhopal, IND. FAU - Kolte, Deepak AU - Kolte D AD - Department of Oral and Maxillofacial Surgery, Bharati Vidyapeeth (Deemed to be University) Dental College and Hospital, Mumbai, IND. FAU - Priyadarshini, Shamurailatpam AU - Priyadarshini S AD - Department of Conservative Dentistry and Endodontics, The Dental College, Regional Institute of Medical Sciences, Imphal, IND. FAU - Katakam, Dilip AU - Katakam D AD - Department of Conservative Dentistry and Endodontics, ESIC Dental College and Hospital, Kalaburagi, IND. FAU - Tiwari, Rahul AU - Tiwari R AD - Department of Oral and Maxillofacial Surgery, RKDF Dental College and Research Centre, Bhopal, IND. FAU - Gupta, Seema AU - Gupta S AD - Department of Orthodontics, Kothiwal Dental College and Research Centre, Moradabad, IND. LA - eng PT - Journal Article DEP - 20260121 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12923985 OTO - NOTNLM OT - children OT - dental caries OT - glass ionomer cement OT - pit and fissure sealants OT - resins COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethical Committee of RKDF Dental College and Research Centre issued approval RKDF/DC/2024/S12. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/02/23 13:06 MHDA- 2026/02/23 13:07 PMCR- 2026/01/21 CRDT- 2026/02/23 06:45 PHST- 2026/01/21 00:00 [accepted] PHST- 2026/02/23 13:07 [medline] PHST- 2026/02/23 13:06 [pubmed] PHST- 2026/02/23 06:45 [entrez] PHST- 2026/01/21 00:00 [pmc-release] AID - 10.7759/cureus.102037 [doi] PST - epublish SO - Cureus. 2026 Jan 21;18(1):e102037. doi: 10.7759/cureus.102037. eCollection 2026 Jan. PMID- 41728422 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260223 LR - 20260813 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 18 IP - 1 DP - 2026 Jan TI - LATCH Score for the Identification and Correction of Breastfeeding Problems: A Prospective Observational Study. PG - e101912 LID - 10.7759/cureus.101912 [doi] LID - e101912 AB - Background Breastfeeding is fundamental to infant survival, growth, and development, offering optimal nutrition and immunological protection while conferring long-term health benefits to both infants and mothers. Despite strong evidence supporting exclusive breastfeeding, early breastfeeding difficulties related to improper latch, positioning, and maternal discomfort remain common, particularly in the immediate postnatal period. Early identification and correction of these problems are essential to ensure successful breastfeeding. This study aimed to assess breastfeeding effectiveness using the LATCH (Latch, Audible swallowing, Type of nipple, Comfort, Hold) scoring system in the early postnatal period and to evaluate the impact of LATCH score-guided counseling and hands-on lactation support on breastfeeding outcomes. Methodology This prospective observational study was conducted among 229 primiparous mother-infant dyads delivering at term in a tertiary care hospital in Karnataka, India. Breastfeeding effectiveness was assessed using the LATCH scoring system at 1-2 hours postpartum and reassessed at 24-48 hours following structured lactation counseling and hands-on support. Data were analyzed using SPSS version 26.0 (IBM Corp., Armonk, NY, USA), and associations were evaluated using appropriate statistical tests, with p-values <0.05 considered statistically significant. Results Most mothers were aged 21-30 years (171; 74.7%). Poor LATCH scores (0-3) were observed in 109 (47.6%) mothers at 1-2 hours postpartum, which reduced to 26 (11.4%) at 24-48 hours. Overall improvement in LATCH scores was noted in 202 (88.2%) mothers. Improvement in LATCH score was significantly associated with antenatal period status (p = 0.021), mode of delivery (p = 0.015), and initial LATCH score at 1-2 hours postpartum (p = 0.016). LATCH assessment at 24-48 hours demonstrated high sensitivity (96.1%) and specificity (99.0%) for predicting improvement in breastfeeding performance. Conclusions LATCH score-guided counseling combined with early postnatal hands-on lactation support significantly improved breastfeeding effectiveness within the first 48 hours postpartum. Assessment at 24-48 hours showed high diagnostic accuracy for identifying improvement in breastfeeding performance, supporting the routine use of LATCH scoring in postnatal care. CI - Copyright (c) 2026, Boora et al. FAU - Boora, Monika R AU - Boora MR AD - Obstetrics and Gynaecology, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND. FAU - Kori, Shreedevi AU - Kori S AD - Obstetrics and Gynaecology, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND. FAU - Shiragur, Shobha AU - Shiragur S AD - Obstetrics and Gynaecology, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND. FAU - Chhabra, Ekta AU - Chhabra E AD - Obstetrics and Gynaecology, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND. FAU - Patil, Mallanagouda M AU - Patil MM AD - Paediatrics, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND. FAU - Umerjikar, Sarvada AU - Umerjikar S AD - Obstetrics and Gynaecology, Shri B. M. Patil Medical College, Hospital and Research Centre, BLDE (Deemed to be University), Vijayapura, IND. LA - eng PT - Journal Article DEP - 20260120 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12919691 OTO - NOTNLM OT - breastfeeding OT - breastfeeding effectiveness OT - lactation counseling OT - latch score OT - postnatal care COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee, BLDE, Vijayapura issued approval BLDE (DU)/IEC-SBMPMC/059/202-24. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/02/23 13:05 MHDA- 2026/02/23 13:06 PMCR- 2026/01/20 CRDT- 2026/02/23 06:45 PHST- 2026/01/20 00:00 [accepted] PHST- 2026/02/23 13:06 [medline] PHST- 2026/02/23 13:05 [pubmed] PHST- 2026/02/23 06:45 [entrez] PHST- 2026/01/20 00:00 [pmc-release] AID - 10.7759/cureus.101912 [doi] PST - epublish SO - Cureus. 2026 Jan 20;18(1):e101912. doi: 10.7759/cureus.101912. eCollection 2026 Jan. PMID- 41727682 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 17 DP - 2026 TI - Automated bone age assessment in rare pediatric growth disorders: a comparative study using Deeplasia. PG - 1741927 LID - 10.3389/fendo.2026.1741927 [doi] LID - 1741927 AB - OBJECTIVE: Bone age (BA) assessment is essential for monitoring growth and maturation and guiding therapeutic interventions. While deep learning (DL) models offer high-speed automated BA prediction, their generalizability to rare pathological and diagnostically complex populations remains a significant concern. This study aims to validate the open-source DL system Deeplasia on external data from pediatric patients with various syndromic, endocrine, and lysosomal storage disorders (LSDs) and to compare its accuracy and consistency against multiple expert human raters. METHODS: We retrospectively assembled 1,138 hand radiographs from multiple centers, including patients with SHOX deficiency; Noonan syndrome; Silver-Russell syndrome; Ullrich-Turner syndrome; pseudohypoparathyroidism; congenital adrenal hyperplasia (CAH); precocious puberty and precocious pseudopuberty (cohort 1); mucopolysaccharidosis types I, II, III, IV, and VI; alpha-mannosidosis; and unclassified LSDs (cohort 2). For each radiograph, BA was evaluated using the Greulich and Pyle method by two to five human experts to obtain a mean BA reference. Model performance was assessed using the mean absolute error (MAE), root mean squared error (RMSE), and 1-year accuracy for each cohort and underlying conditions, sex, and age groups. Furthermore, Deeplasia's performance was compared with that of individual raters by testing each rater and the model against the remaining experts. RESULTS: Deeplasia achieved a mean MAE of 5.95 months, an RMSE of 8.01 months, and a 1-year accuracy of 89.9% for cohort 1 (endocrine and syndromic conditions). For cohort 2 (lysosomal storage disorders), Deeplasia achieved a mean MAE of 7.13 months, an RMSE of 9.56 months, and a 1-year accuracy of 81.2%. In direct comparisons between Deeplasia and individual raters tested against the remaining experts, Deeplasia outperformed all human raters. CONCLUSION: Deeplasia was validated as a highly consistent, robust, and reliable tool for BA assessment in complex cases. It demonstrated superior accuracy compared with individual human raters and may assist clinicians in BA evaluation. CI - Copyright (c) 2026 Skaf, Fardipour, Schmidt, Bolmer, Keller, Lampe, Jurgens, Lindschau, Palm, Ruckdeschel, Javanmardi and Mohnike. FAU - Skaf, Kyra AU - Skaf K AD - Medical Faculty, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany. FAU - Fardipour, Minu AU - Fardipour M AD - Medical Faculty, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany. FAU - Schmidt, Philipp AU - Schmidt P AD - Medical Faculty, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany. FAU - Bolmer, Eike AU - Bolmer E AD - Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn, Bonn, Germany. FAU - Keller, Alexandra AU - Keller A AD - Kinderzentrum Am Johannisplatz, Leipzig, Germany. FAU - Lampe, Christina AU - Lampe C AD - Centre for Rare Diseases, University Hospital of Giessen, Giessen, Germany. FAU - Jurgens, Julian AU - Jurgens J AD - Division of Pediatric Radiology, Department of Radiology, University Hospital Hamburg, Hamburg, Germany. FAU - Lindschau, Mona AU - Lindschau M AD - International Center for Lysosomal Disorders (ICLD), Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. FAU - Palm, Katja AU - Palm K AD - Medical Faculty, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany. FAU - Ruckdeschel, Sophie AU - Ruckdeschel S AD - Medical Faculty, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany. FAU - Javanmardi, Behnam AU - Javanmardi B AD - Institute for Genomic Statistics and Bioinformatics, University Hospital Bonn, Bonn, Germany. FAU - Mohnike, Klaus AU - Mohnike K AD - Medical Faculty, Otto-Von-Guericke-University Magdeburg, Magdeburg, Germany. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260206 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Age Determination by Skeleton/methods MH - Female MH - Retrospective Studies MH - Child MH - Child, Preschool MH - *Growth Disorders/diagnostic imaging/diagnosis MH - Male MH - Infant MH - *Deep Learning MH - Adolescent MH - *Rare Diseases/diagnostic imaging PMC - PMC12921578 OTO - NOTNLM OT - Greulich and Pyle method OT - artificial intelligence OT - bone age OT - deeplasia OT - pediadtric radiology OT - rare growth disorders COIS- The authors declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author KM declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/02/23 13:05 MHDA- 2026/02/23 13:06 PMCR- 2026/02/06 CRDT- 2026/02/23 06:38 PHST- 2025/11/07 00:00 [received] PHST- 2025/12/15 00:00 [revised] PHST- 2026/01/09 00:00 [accepted] PHST- 2026/02/23 13:06 [medline] PHST- 2026/02/23 13:05 [pubmed] PHST- 2026/02/23 06:38 [entrez] PHST- 2026/02/06 00:00 [pmc-release] AID - 10.3389/fendo.2026.1741927 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Feb 6;17:1741927. doi: 10.3389/fendo.2026.1741927. eCollection 2026. PMID- 41727319 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260223 LR - 20260813 IS - 2296-634X (Print) IS - 2296-634X (Electronic) IS - 2296-634X (Linking) VI - 14 DP - 2026 TI - Current insights into circulating biomarkers and their potential for predicting adolescent idiopathic scoliosis progression. PG - 1760636 LID - 10.3389/fcell.2026.1760636 [doi] LID - 1760636 AB - Adolescent Idiopathic Scoliosis (AIS) is a three-dimensional deformation of the spine with a frontal plane curvature of 10 degrees or more, measured using Cobb method. It typically gets more severe during pre-puberty and puberty, currently exhibiting unpredictable progression. Severe disease is more prevalent in females, and progression is associated with respiratory and neuromuscular dysfunction, pain, and psychological complications. Management strategies are guided by curve severity and include observation, therapeutic exercises, bracing, and surgery. Despite advances, the cellular and molecular mechanisms driving AIS remain poorly understood. Early detection and reliable progression biomarkers are increasingly recognized as critical to prevent clinical mismanagement. This mini-review summarizes current evidence on circulating biomarkers investigated in AIS, including growth-related hormones, bone metabolism proteins, and more recently non-coding RNAs (ncRNAs) such as microRNAs. In addition, we highlight key methodological limitations and risk-of-bias concerns across existing studies, especially the reliance on single-time-point sampling, underscoring the need for longitudinal prospective cohorts with repeated biomarker measurements. Such designs are critical for capturing dynamic biological changes, distinguishing stable from progressive cases, and validating biomarker trajectories for integration into clinically meaningful prediction models for AIS progression. CI - Copyright (c) 2026 Raimondi, Colombini, Ruffilli, Perna, Negrini, Toscano and Giavaresi. FAU - Raimondi, Lavinia AU - Raimondi L AD - Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. FAU - Colombini, Alessandra AU - Colombini A AD - Orthopaedic Biotechnology Lab., IRCCS Galeazzi S. Ambrogio Hospital, Milan, Italy. FAU - Ruffilli, Alberto AU - Ruffilli A AD - 1st Orthopaedic and Traumatologic Clinic, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. FAU - Perna, Fabrizio AU - Perna F AD - General Orthopaedic, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. FAU - Negrini, Stefano AU - Negrini S AD - Department of Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy. AD - Laboratory of Evidence Based Rehabilitation, IRCCS Galeazzi S. Ambrogio Hospital, Milan, Italy. FAU - Toscano, Angelo AU - Toscano A AD - General Orthopaedic, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. FAU - Giavaresi, Gianluca AU - Giavaresi G AD - Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. LA - eng PT - Journal Article PT - Review DEP - 20260206 PL - Switzerland TA - Front Cell Dev Biol JT - Frontiers in cell and developmental biology JID - 101630250 PMC - PMC12920475 OTO - NOTNLM OT - adolescent idiopathic scoliosis (AIS) OT - biomarker validation in AIS OT - bone metabolism markers OT - circulating biomarkers OT - disease progression OT - microRNAs (miRNAs) detection OT - pathophysiology of scoliosis COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/23 13:06 MHDA- 2026/02/23 13:07 PMCR- 2026/02/06 CRDT- 2026/02/23 06:35 PHST- 2025/12/04 00:00 [received] PHST- 2025/12/29 00:00 [revised] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/02/23 13:07 [medline] PHST- 2026/02/23 13:06 [pubmed] PHST- 2026/02/23 06:35 [entrez] PHST- 2026/02/06 00:00 [pmc-release] AID - 1760636 [pii] AID - 10.3389/fcell.2026.1760636 [doi] PST - epublish SO - Front Cell Dev Biol. 2026 Feb 6;14:1760636. doi: 10.3389/fcell.2026.1760636. eCollection 2026. PMID- 41727210 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260223 LR - 20260813 IS - 2054-3581 (Print) IS - 2054-3581 (Electronic) IS - 2054-3581 (Linking) VI - 13 DP - 2026 TI - Integrating the Novel iCARE Estimated Glomerular Filtration Rate Equation for Youth Living With Type 2 Diabetes Into Care: Program Report. PG - 20543581251413452 LID - 10.1177/20543581251413452 [doi] LID - 20543581251413452 AB - PURPOSE OF THE PROGRAM: Youth living with type 2 diabetes (T2D) have high rates of early kidney disease and progression to kidney failure in early adulthood. Pediatric diabetes clinical practice guidelines have focused on screening for albuminuria and have not included recommendations for estimated glomerular filtration rate (eGFR) evaluation in children. In partnership with patients, families, and community partners, we are implementing a novel eGFR equation for youth with T2D into their diabetes care, with the aim of detecting youth with early kidney disease and providing appropriate interventions to slow disease progression. SOURCES OF INFORMATION: The development of such a tool aligned with a priority-setting workshop in 2016, where early detection and prevention of kidney disease were identified as a key priority by people living with kidney disease. In response, our team developed the novel Improving renal Complications in Adolescents with type 2 diabetes through Research (iCARE) eGFR equation, which estimates kidney function over time in youth with T2D, and validated it in a cohort of youth in Colorado (US) and a secondary group of youth in Manitoba (Canada). METHODS: To integrate the tool into clinical care, this study includes 4 separate phases. Phase 1: External validation of the iCARE eGFR equation in a cohort of children with obesity and T2D from Colorado, US, to assess the generalizability of the equation. Phase 2: Readiness Assessment of pediatric endocrinologists (a) quantitative survey in Canada (n = 40) and the United States (n = 75) to assess current practice for screening youth with T2D for diabetic kidney disease (DKD) and (b) qualitative focus groups (4 groups; 2 in Canada [n = 8] and 2 in the United States [n = 5]) to explore barriers and facilitators to implementation of the iCARE eGFR equation into the care for youth with T2D. Focus groups of youth living with T2D are underway and explore how youth and families wish to be educated regarding kidney health and what sources of information would be helpful to empower youth to ask about kidney health in clinical settings. Phase 3: Development and implementation of an iCARE eGFR equation toolkit, which will include the resources for providers and patient education materials and the inclusion of the novel eGFR equation into an app and local electronic medical record systems at 3 sites (Vancouver, Winnipeg, Toronto). Phase 4: Evaluation of the iCARE eGFR implementation toolkit, including audits at 3 centers in Canada, as well as patient and provider satisfaction surveys. KEY FINDINGS: Phase 1: The validation study confirmed that the iCARE eGFR performed better than previously published eGFR equations in youth living with obesity and T2D. Relevant metrics were the highest P30 (% of eGFR values that fall within 30% of the measured glomerular filtration rate [GFR]) and the lowest bias. Phase 2: Survey results suggest that providers have strong adherence to existing T2D clinical practice guidelines, focused on albuminuria, but have limited experience and comfort with eGFR equations in general. Focus group discussions identified concerns about insufficient evidence indicating that eGFR metrics in childhood are associated with long-term outcomes and questions about generalizability and external validity. Key facilitators for improving uptake included development of a more comprehensive app or platform that presents eGFR findings in an accessible way for endocrinologists and development of clinical pathway guidelines to support follow-up treatment. IMPLICATIONS: Findings from phases 1 and 2 will be incorporated into the iCARE eGFR implementation toolkit, such that care providers and patients are able to utilize the most up-to-date evidence to screen for DKD and implement care strategies that will optimize the long-term kidney health of youth living with T2D. CI - (c) The Author(s) 2026. FAU - Dart, Allison B AU - Dart AB AUID- ORCID: 0000-0002-4718-9408 AD - Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. AD - DREAM Research Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada. FAU - Zhou, J Grace AU - Zhou JG AUID- ORCID: 0000-0003-4201-0699 AD - DREAM Research Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada. FAU - Sellers, Elizabeth A C AU - Sellers EAC AD - Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. AD - DREAM Research Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada. FAU - Hamilton, Jill AU - Hamilton J AD - Department of Paediatrics, University of Toronto, Canada. FAU - Basak, Sanjukta AU - Basak S AD - Department of Pediatrics, University of British Columbia, Vancouver, Canada. FAU - Ryan, Paul AU - Ryan P AD - Department of Paediatrics, University of Toronto, Canada. FAU - Garcia Acevedo, Giliana P AU - Garcia Acevedo GP AD - Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. FAU - Hunt, Brianna AU - Hunt B AD - DREAM Research Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada. FAU - Del Vecchio, Melissa AU - Del Vecchio M AD - DREAM Research Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada. FAU - Lopez, Jennifer AU - Lopez J AD - iCARE Study, DREAM Research Theme and Can-SOLVE CKD, Winnipeg, MB, Canada. FAU - Alecio-Garcia, Onalee AU - Alecio-Garcia O AD - iCARE Study, DREAM Research Theme and Can-SOLVE CKD, Winnipeg, MB, Canada. FAU - Onyiuke, Chukwudumebi AU - Onyiuke C AD - Four Arrow Regional Health Authority, Winnipeg, MB, Canada. FAU - Linklater, Jacqueline AU - Linklater J AD - Four Arrow Regional Health Authority, Winnipeg, MB, Canada. FAU - Umaefulam, Valerie AU - Umaefulam V AUID- ORCID: 0000-0003-4239-7715 AD - George and Faye Centre for Healthcare Innovation, College of Community and Global Health, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. FAU - Tommerdahl, Kalie AU - Tommerdahl K AUID- ORCID: 0000-0003-1132-1574 AD - Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, USA. FAU - Bjornstad, Petter AU - Bjornstad P AD - Division of Metabolism, Endocrinology and Nutrition, Department of Medicine, University of Washington, Seattle, USA. FAU - Wicklow, Brandy A AU - Wicklow BA AD - Department of Pediatrics and Child Health, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada. AD - DREAM Research Theme, Children's Hospital Research Institute of Manitoba, Winnipeg, Canada. LA - eng PT - Journal Article DEP - 20260218 PL - England TA - Can J Kidney Health Dis JT - Canadian journal of kidney health and disease JID - 101640242 PMC - PMC12921172 OTO - NOTNLM OT - eGFR OT - evaluation OT - knowledge mobilization OT - type 2 diabetes OT - youth COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/02/23 13:05 MHDA- 2026/02/23 13:06 PMCR- 2026/02/18 CRDT- 2026/02/23 06:34 PHST- 2025/12/09 00:00 [received] PHST- 2025/12/17 00:00 [accepted] PHST- 2026/02/23 13:06 [medline] PHST- 2026/02/23 13:05 [pubmed] PHST- 2026/02/23 06:34 [entrez] PHST- 2026/02/18 00:00 [pmc-release] AID - 10.1177_20543581251413452 [pii] AID - 10.1177/20543581251413452 [doi] PST - epublish SO - Can J Kidney Health Dis. 2026 Feb 18;13:20543581251413452. doi: 10.1177/20543581251413452. eCollection 2026. PMID- 41726842 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260223 LR - 20260813 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Exercise prescription to improve executive functioning in children and adolescents with attention deficit hyperactivity disorder: a network meta-analysis. PG - 1716578 LID - 10.3389/fpsyt.2026.1716578 [doi] LID - 1716578 AB - OBJECTIVE: This study employs a network meta-analysis to investigate the potential effects of exercise type, duration, frequency, intensity, and cycle on executive functions (inhibitory control, working memory, cognitive flexibility) in children and adolescents with ADHD, thereby providing directional insights for future research. METHODS: Five databases were systematically searched up to February 1, 2025, yielding 21 RCTs (n = 1,491) involving participants aged 7-18 years. The risk of bias was assessed using Cochrane tools. Standardised mean differences (SMDs) were used as effect measures, while SUCRA was used for probability ranking and GRADE for evidence quality grading. RESULTS: Skill-based exercise outperformed isolated aerobic exercise in inhibitory control (SMD = 0.73, 95% CI 0.31-1.41) and cognitive flexibility (SMD = 3.08, 95% CI 0.52-5.63). Combined exercise outperformed controls in working memory (SMD = 0.73, 95% CI 0.35-1.12). SUCRA ranking indicated the highest cumulative probability for skill-based exercise in inhibitory control (95.8) and cognitive flexibility (95.5), while aerobic exercise had the highest probability for working memory (87.1). Sensitivity analyses indicated that estimates for cognitive flexibility were significantly influenced by individual studies, demonstrating limited robustness. CONCLUSION: Preliminary evidence suggests that moderate-intensity, skill-based exercise may improve inhibitory control and cognitive flexibility within 6-10 weeks. Aerobic exercise may enhance working memory within 4-5 weeks. However, factors such as ADHD subtypes, age, and dose-response relationships remain unclear. Clinical implementation should be individualised and await high-quality validation. CI - Copyright (c) 2026 Yang, Zhao, Hu and Zhou. FAU - Yang, Zixuan AU - Yang Z AD - Department of Leisure Services Sports, Pai Chai University, Daejeon, Republic of Korea. FAU - Zhao, Ke AU - Zhao K AD - Department of Physical Education, Zhangjiakou University, Zhangjiakou, Hebei, China. FAU - Hu, Yuanye AU - Hu Y AD - Department of Leisure Services Sports, Pai Chai University, Daejeon, Republic of Korea. FAU - Zhou, Qinhan AU - Zhou Q AD - Department of Leisure Services Sports, Pai Chai University, Daejeon, Republic of Korea. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260205 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC12916422 OTO - NOTNLM OT - adolescents OT - children OT - executive function OT - exercise prescription OT - network meta-analysis COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/23 13:06 MHDA- 2026/02/23 13:07 PMCR- 2026/02/05 CRDT- 2026/02/23 06:27 PHST- 2025/09/30 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2026/01/02 00:00 [accepted] PHST- 2026/02/23 13:07 [medline] PHST- 2026/02/23 13:06 [pubmed] PHST- 2026/02/23 06:27 [entrez] PHST- 2026/02/05 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1716578 [doi] PST - epublish SO - Front Psychiatry. 2026 Feb 5;17:1716578. doi: 10.3389/fpsyt.2026.1716578. eCollection 2026. PMID- 41725766 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Self-efficacy in lifestyle management among young Arab adults: a cross-cultural study in the EMRO region. PG - 1633934 LID - 10.3389/fpubh.2026.1633934 [doi] LID - 1633934 AB - OBJECTIVES: The aim of this study was to assess the self-efficacy of lifestyle practices among young adults, including late adolescents aged 18-19 years, across the Arab region. METHODS: A multinational cross-sectional online survey was conducted using convenience sampling between September 2022 and September 2023 (n = 2,708) across multiple Arab regions (the Arabian Peninsula, Africa, and the Eastern Mediterranean, but outside African countries). Individuals of both sexes, aged 18-25 years, who could read and understand Arabic and who resided in one of the Arab regions, were included. Sociodemographic data were also collected. A previously validated Arabic questionnaire was used to assess self-efficacy and knowledge of healthy lifestyles. RESULTS: Individuals in the Northern Africa region (9.7 +/- 3.5) had significantly lower total self-efficacy scores than those in the Arabian Peninsula (11.5 +/- 2.8) and Eastern Mediterranean region (11.7 +/- 2.7; p < 0.001, F = 132.3). The knowledge score was significantly lower in Northern Africa (5.4 +/- 2.3), whereas the Arabian Peninsula had the highest knowledge score (7.2 +/- 1.9; p < 0.001, F = 173.2). Knowledge was associated with self-efficacy in the Arabian Peninsula (R(2) = 0.013, p = 0.016). Age and sex were related to self-efficacy in the Eastern Mediterranean region (R(2) = 0.01, p = 0.007). In North Africa, age, sex, and knowledge were related to self-efficacy (R(2) = 0.25, p < 0.001). These findings indicate that regional differences are related to cultural factors such as age, sex, and knowledge. CONCLUSION: Self-efficacy was lower in Northern African countries than in the Arabian Peninsula or Eastern Mediterranean countries. Age, sex, and nutritional knowledge were associated with self-efficacy. These findings may guide culturally sensitive public health interventions in Arab countries. Future research should explore these relationships using longitudinal designs to better understand the causal pathways between culture, knowledge, sociodemographic factors, and self-efficacy. CI - Copyright (c) 2026 Alzaben, Mahboub, Bawazeer, Almoayad, Bakry, Abusalih, Hussein, Alkilani and Benajiba. FAU - Alzaben, Abeer Salman AU - Alzaben AS AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Mahboub, Samira AU - Mahboub S AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Bawazeer, Nahla Mohammed AU - Bawazeer NM AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Almoayad, Fatmah AU - Almoayad F AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Bakry, Huny M AU - Bakry HM AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Abusalih, Howeida H AU - Abusalih HH AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Hussein, Yasir Najah AU - Hussein YN AD - Collage of Physical Education and Sport Sciences, University of Baghdad, Baghdad, Iraq. FAU - Alkilani, Laila AU - Alkilani L AD - Department of Physical Sport Sciences, College of Sport Sciences & Physical Activity, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Benajiba, Nada AU - Benajiba N AD - Unite Mixte de Recherche en Nutrition et Alimentation URAC 39 (Universite Ibn Tofail-CNESTEN), RDC-Nutrition, Kenitra, Morocco. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260205 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Young Adult MH - *Arabs/statistics & numerical data/psychology MH - *Cross-Cultural Comparison MH - Cross-Sectional Studies MH - *Health Knowledge, Attitudes, Practice MH - *Life Style MH - Middle East MH - Middle Eastern People MH - *Self Efficacy MH - Surveys and Questionnaires PMC - PMC12916375 OTO - NOTNLM OT - Arabian Peninsula OT - eastern Mediterranean OT - knowledge OT - northern Africa OT - nutrition OT - self-efficacy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/23 13:06 MHDA- 2026/02/23 13:07 PMCR- 2026/02/05 CRDT- 2026/02/23 06:15 PHST- 2025/05/23 00:00 [received] PHST- 2026/01/17 00:00 [revised] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/02/23 13:07 [medline] PHST- 2026/02/23 13:06 [pubmed] PHST- 2026/02/23 06:15 [entrez] PHST- 2026/02/05 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1633934 [doi] PST - epublish SO - Front Public Health. 2026 Feb 5;14:1633934. doi: 10.3389/fpubh.2026.1633934. eCollection 2026. PMID- 41725599 OWN - NLM STAT- MEDLINE DCOM- 20260619 LR - 20260619 IS - 1461-7021 (Electronic) IS - 1359-1045 (Linking) VI - 31 IP - 3 DP - 2026 Jul TI - Trauma Adapted Yoga as an Adjunct to Psychiatric Treatment on an Adolescent Inpatient Unit. PG - 945-959 LID - 10.1177/13591045261424539 [doi] AB - PurposeTrauma-adapted yoga (TAY) is a yoga adaptation developed for trauma-exposed populations that emphasizes autonomy and targets nervous system regulation. This study evaluates TAY's impact on distress and psychiatric symptoms over the course of a psychiatric hospitalization, building on the results of a prior feasibility study that suggested TAY reduced participants' anxiety and emotional pain immediately following group sessions.MethodsThis is a retrospective study. Adolescents voluntarily joined either a yoga or non-yoga (control) group. TAY was offered twice weekly alongside standard care. The Youth Outcome Questionnaire 2.0 was administered at admission and discharge to measure patient distress and assess change over the course of hospitalization. Participants also completed ratings of anxiety, emotional pain, and physical pain pre-and-post-yoga sessions.ResultsOver 27 weeks, 129 adolescents participated with 112 opting into the yoga group. Participants were predominantly female, white, and non-Hispanic. Major Depressive Disorder was the most common discharge diagnosis; 71% of participants reported trauma histories. Yoga participation significantly reduced Y-OQ scores whereas controls had no significant reductions over the course of hospitalization.ConclusionFindings show TAY practice during psychiatric hospitalization may reduce overall distress and imply a need for future inpatient standard programming and research. FAU - Chung, Theresa AU - Chung T AUID- ORCID: 0009-0001-7883-5839 AD - Department of Psychiatry, Norton College of Medicine at SUNY Upstate Medical University, Syracuse, NY, USA. RINGGOLD: 12302 FAU - Duquette, Jacquelynn AU - Duquette J AUID- ORCID: 0009-0003-2085-9533 AD - Department of Psychiatry, Norton College of Medicine at SUNY Upstate Medical University, Syracuse, NY, USA. RINGGOLD: 12302 FAU - Zhang-James, Yanli AU - Zhang-James Y AD - Department of Psychiatry, Norton College of Medicine at SUNY Upstate Medical University, Syracuse, NY, USA. RINGGOLD: 12302 FAU - Hagen, Kathryn AU - Hagen K AD - Department of Psychiatry, Norton College of Medicine at SUNY Upstate Medical University, Syracuse, NY, USA. RINGGOLD: 12302 FAU - Biedrzycki, Joseph J AU - Biedrzycki JJ AD - Department of Psychiatry, Norton College of Medicine at SUNY Upstate Medical University, Syracuse, NY, USA. RINGGOLD: 12302 FAU - Cote, John AU - Cote J AD - Department of Psychiatry, Norton College of Medicine at SUNY Upstate Medical University, Syracuse, NY, USA. RINGGOLD: 12302 FAU - Nepal, Mihika AU - Nepal M AD - Department of Psychiatry, Norton College of Medicine at SUNY Upstate Medical University, Syracuse, NY, USA. RINGGOLD: 12302 FAU - Carbone, Stephanie AU - Carbone S AD - Department of Psychiatry, Norton College of Medicine at SUNY Upstate Medical University, Syracuse, NY, USA. RINGGOLD: 12302 FAU - Khoury, Nayla M AU - Khoury NM AD - Department of Psychiatry, Norton College of Medicine at SUNY Upstate Medical University, Syracuse, NY, USA. RINGGOLD: 12302 LA - eng PT - Journal Article DEP - 20260223 PL - England TA - Clin Child Psychol Psychiatry JT - Clinical child psychology and psychiatry JID - 9604507 SB - IM MH - Humans MH - *Yoga/psychology MH - Female MH - Adolescent MH - Male MH - Retrospective Studies MH - Inpatients/psychology MH - *Major Depressive Disorder/therapy MH - *Anxiety/therapy OAB - Adolescents admitted to psychiatric units can struggle with a variety of mental health concerns including depression, anxiety, and post-traumatic stress disorder (PTSD). The current standard for psychiatric treatment consists of therapy and medication. However, there is an evolving interest in alternative modalities that support patients holistically. One increasingly popular alternative is yoga, a practice research suggests improves physical activity as well as mental and emotional well-being. Yoga is unique when used as an adjunct to medicine as its adaptability promotes accessibility for adolescents of all backgrounds and abilities. This study looked at an alternative form of yoga known as trauma-adapted yoga (TAY), designed specifically for people who have experienced trauma. Unlike traditional yoga, TAY avoids things like instructors touching participants to correct poses or language that can sound controlling; instead, it promotes safety, participant choice, and body awareness. Over 27 weeks, 129 adolescents aged 12-18 admitted to an inpatient psychiatric unit were offered the choice to participate in yoga in addition to their usual care. TAY sessions were led by trained clinicians twice a week and patients provided feedback on how they felt before and after yoga. Most chose to take part in yoga and said they felt less emotional pain, as well as less distress and anxiety. Participation in TAY demonstrated significant reductions in overall distress, anxiety, and emotional pain over the course of hospitalization. The findings suggest that participating in TAY has potential to lessen adolescent patients' distress and anxiety while hospitalized on a psychiatric unit. This study is one of few, but its findings and growing interest in holistic methods of care encourage more research to be done on the effectiveness of TAY as a treatment resource within psychiatry. OABL- eng OTO - NOTNLM OT - child and adolescent OT - child and adolescent psychiatry OT - complementary and alternative medicine OT - inpatient psychiatry OT - mindfulness OT - psychiatry OT - trauma OT - trauma-adapted yoga OT - yoga COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/02/23 06:27 MHDA- 2026/06/19 06:32 CRDT- 2026/02/23 05:53 PHST- 2026/06/19 06:32 [medline] PHST- 2026/02/23 06:27 [pubmed] PHST- 2026/02/23 05:53 [entrez] AID - 10.1177/13591045261424539 [doi] PST - ppublish SO - Clin Child Psychol Psychiatry. 2026 Jul;31(3):945-959. doi: 10.1177/13591045261424539. Epub 2026 Feb 23. PMID- 41725550 OWN - NLM STAT- MEDLINE DCOM- 20260623 LR - 20260706 IS - 1473-0804 (Electronic) IS - 1369-7137 (Linking) VI - 29 IP - 3 DP - 2026 Jun TI - Hot flashes: a potential marker of deterioration of health-related quality of life. PG - 462-469 LID - 10.1080/13697137.2026.2627561 [doi] AB - OBJECTIVE: Hot flashes are among the most common symptoms of the menopausal transition and have traditionally been considered benign and self-limiting. However, increasing evidence suggests that they may indicate broader neurovascular and inflammatory dysregulation linked to reproductive aging. The possible effect of hot flush severity on health-related quality of life (HRQoL) remains inadequately studied, particularly in Latin American populations. This study aimed to examine the association between hot flash severity and HRQoL in middle-aged women using validated tools and a large, multicenter sample. METHOD: A cross-sectional study was conducted between June 2024 and January 2025 in 30 healthcare centers across 12 Latin American countries. A total of 3523 women aged 40-60 years were assessed using the Menopause Rating Scale (MRS) to evaluate vasomotor symptoms and the Short Form-36 Health Survey (SF-36) to measure HRQoL. Multivariable logistic regression models were utilized to estimate the association between hot flush severity and low HRQoL, adjusting for sociodemographic, behavioral and clinical covariates. RESULTS: Increasing severity of hot flushes was significantly associated with lower HRQoL scores across all SF-36 domains. In the logistic regression analysis, mild hot flushes (MRS item 1 score = 1) were associated with increased odds of impaired HRQoL (odds ratio [OR] 1.29; 95% confidence interval [CI]: 1.08-1.55), whereas very severe symptoms (MRS item 1 score = 4) demonstrated a substantially stronger association (OR 4.10; 95% CI: 2.93-5.74). Additional factors significantly associated with lower HRQoL included physical inactivity, the presence of comorbidities, obesity, current use of psychotropic medication, age >/=50 years and having two or more children. CONCLUSION: Hot flush severity is a strong and independent determinant of HRQoL in midlife women. These findings underscore the need for systematic assessment and targeted management of vasomotor symptoms in routine care, supporting the hypothesis that hot flashes may be a clinical marker of systemic aging. FAU - Blumel, Juan E AU - Blumel JE AD - Departamento de Medicina Interna Sur, Facultad de Medicina, Universidad de Chile, Santiago de Chile, Chile. FAU - Vallejo, Maria S AU - Vallejo MS AD - Servicio de Ginecologia y Obstetricia, Hospital Clinico, Universidad de Chile, Santiago de Chile, Chile. FAU - Chedraui, Peter AU - Chedraui P AD - Escuela de Postgrado en Salud, Universidad Espiritu Santo, Samborondon, Ecuador. FAU - Arteaga, Eugenio AU - Arteaga E AD - Departamento de Endocrinologia y CETREN, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago de Chile, Chile. FAU - Ayala, Felix AU - Ayala F AD - Departamento de Ginecologia y Obstetricia, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Peru. FAU - Bencosme, Ascanio AU - Bencosme A AD - Facultad de Ciencias de la Salud, Universidad Autonoma de Santo Domingo, Santo Domingo, Republica Dominicana. FAU - Calle, Andres AU - Calle A AD - Centro Integral de Salud Obstetrica y Femenina. Facultad de Ciencias de la Salud, Universidad Indoamerica, Academia Ecuatoriana de Medicina, Quito, Ecuador. FAU - Costa-Paiva, Lucia AU - Costa-Paiva L AD - Department of Obstetrics and Gynecology, Universidade Estadual de Campinas, Campinas, Brazil. FAU - Dextre, Maribel AU - Dextre M AD - Ginecologia y Obstetricia, Clinica Internacional, Lima, Peru. FAU - Diaz, Karen AU - Diaz K AD - Centro Ciudad Mujer, Ministerio de Salud, Asuncion, Paraguay. FAU - Elizalde-Cremonte, Alejandra AU - Elizalde-Cremonte A AD - Departamento de la Mujer, Ninez y Adolescencia, Facultad de Medicina, de la Universidad Nacional del Nordeste, Corrientes, Argentina. FAU - Elizalde-Cremonte, Santiago AU - Elizalde-Cremonte S AD - Departamento de la Mujer, Ninez y Adolescencia, Facultad de Medicina, de la Universidad Nacional del Nordeste, Corrientes, Argentina. FAU - Escalante, Carlos AU - Escalante C AD - Departamento de Ginecologia, Facultad de Medicina, Universidad de Costa Rica, San Jose, Costa Rica. FAU - Espinoza, Maria T AU - Espinoza MT AD - Unidad de Menopausia y Climaterio, Clinica Los Angeles, Cochabamba, Bolivia. FAU - Garcia, Ircania AU - Garcia I AD - Centro Medico Moderno, Santo Domingo, Republica Dominicana. FAU - Gomez-Tabares, Gustavo AU - Gomez-Tabares G AD - Unidad de Medicina Reproductiva, Clinica Imbanaco, Universidad del Valle, Cali, Colombia. FAU - Gutierrez-Crespo, Hugo AU - Gutierrez-Crespo H AD - Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Peru. FAU - Lopez, Marcela AU - Lopez M AD - Departamento de Ginecologia y Obstetricia, Facultad de Medicina, Universidad de Santiago, Santiago de Chile, Chile. FAU - Matsumura-Kasana, Juan AU - Matsumura-Kasana J AD - Unidad de Investigacion, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Peru. FAU - Meza, Paolo AU - Meza P AD - Medicina Familiar, Hospital Nacional Cayetano Heredia, Lima, Peru. FAU - Monterrosa-Castro, Alvaro AU - Monterrosa-Castro A AD - Grupo de Investigacion Salud de la Mujer, Universidad de Cartagena, Cartagena, Colombia. FAU - Nanez, Monica AU - Nanez M AD - II Catedra de Ginecologia, Universidad Nacional de Cordoba, Cordoba, Argentina. FAU - Ojeda, Eliana AU - Ojeda E AD - Departamento Academico de Medicina Humana, Universidad Andina del Cusco, Cusco, Peru. FAU - Rey, Claudia AU - Rey C AUID- ORCID: 0000-0002-0853-300X AD - Asociacion Argentina para el Estudio del Climaterio, Buenos Aires, Argentina. FAU - Valadares, Ana Lucia Ribeiro AU - Valadares ALR AD - Universidade Estadual de Campinas (UNICAMP), Campinas, Sao Paulo, Brasil. FAU - Rodriguez-Vidal, Doris AU - Rodriguez-Vidal D AD - Hospital de Clinicas Jose de San Martin, Universidad de Buenos Aires, Buenos Aires, Argentina. FAU - Rodrigues, Marcio Ah AU - Rodrigues MA AD - Department of Gynecology and Obstetrics, Federal University of Minas Gerais, Belo Horizonte, Brazil. FAU - Saavedra, Javier AU - Saavedra J AD - Departamento de Medicina Interna, Facultad de Medicina, Universidad Mayor de San Simon, Cochabamba, Bolivia. FAU - Salinas, Carlos AU - Salinas C AD - Servicio de Obstetricia y Ginecologia, Hospital Angeles, Puebla, Mexico. FAU - Sosa, Lida AU - Sosa L AD - Servicio de Ginecologia, Hospital Central del Instituto de Prevision Social, Asuncion, Paraguay. FAU - Tserotas, Konstantinos AU - Tserotas K AD - Clinica Tserotas, y Departamento de Ginecologia y Obstetricia Hospital Paitilla, Ciudad de Panama, Panama. FAU - Acuna-San Martin, Margot AU - Acuna-San Martin M AD - Departamento de Obstetricia y Ginecologia, Facultad de Medicina, Universidad de la Frontera (UFRO), Temuco, Chile. FAU - Aguirre, Marcela S AU - Aguirre MS AD - Departamento de Climaterio, Hospital Escuela Eva Peron, Granadero Baigorria, Santa Fe, Argentina. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260223 PL - England TA - Climacteric JT - Climacteric : the journal of the International Menopause Society JID - 9810959 SB - IM MH - Humans MH - *Hot Flashes/psychology/physiopathology MH - *Quality of Life MH - Female MH - Middle Aged MH - Cross-Sectional Studies MH - Adult MH - Severity of Illness Index MH - *Menopause/physiology MH - Surveys and Questionnaires OAB - Hot flashes are one of the most common symptoms that women experience during midlife. They are often regarded as a temporary and harmless symptom. However, updated research indicates that frequent or severe hot flashes could signal broader changes in the body, impacting blood vessels, the brain and aging. In the present study, more than 3500 women (aged 40-60 years) from 12 Latin American countries participated. They completed questionnaires that assessed hot flash severity and their health-related quality of life (HRQoL) in domains such as physical health, emotional well-being, energy and daily activities. We found that women experiencing more severe hot flashes were significantly more likely to report a lower HRQoL, even after considering confounding factors such as age, body mass index, medical conditions and lifestyle. Severe hot flashes nearly doubled the likelihood of poor HRQoL. Conversely, women currently using menopausal hormone therapy had a reduced risk of poor HRQoL. These findings indicate that hot flushes are not only unpleasant but can also significantly affect women's health and everyday life. Healthcare professionals should pay close attention to hot flushes and assist women in finding effective management strategies, as they may also signal overall aging and health concerns. OABL- eng OTO - NOTNLM OT - Hot flushes OT - health OT - menopausal hormone therapy OT - obesity OT - physical inactivity OT - quality of life EDAT- 2026/02/23 06:27 MHDA- 2026/06/23 12:34 CRDT- 2026/02/23 05:13 PHST- 2026/06/23 12:34 [medline] PHST- 2026/02/23 06:27 [pubmed] PHST- 2026/02/23 05:13 [entrez] AID - 10.1080/13697137.2026.2627561 [doi] PST - ppublish SO - Climacteric. 2026 Jun;29(3):462-469. doi: 10.1080/13697137.2026.2627561. Epub 2026 Feb 23. PMID- 41725311 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1099-0496 (Electronic) IS - 8755-6863 (Print) IS - 1099-0496 (Linking) VI - 61 IP - 2 DP - 2026 Feb TI - Management of Cystic Fibrosis-Related Diabetes in Denmark-A Population-Based, Cross-Sectional Study. PG - e71533 LID - 10.1002/ppul.71533 [doi] LID - e71533 AB - BACKGROUND: Cystic fibrosis-related diabetes (CFRD) is the most common comorbidity in cystic fibrosis (CF). After the introduction of modulator therapy, extended life expectancy and altered nutritional status may have changed the landscape of CFRD. This study aimed to evaluate the current CFRD management in Denmark. METHODS: In a nationwide, cross-sectional study, we included all individuals in Denmark diagnosed with CFRD, defined by insulin use, >/=2 abnormal OGTTs (2-h glucose >/=11.1 mmol/L), or elevated HbA1c (>48 mmol/mol). The cohort was identified using the Danish CF Registry, including all CF cases in Denmark. Health records were reviewed to validate diagnoses and extract data on treatment regimens and glycemic control. RESULTS: We identified 151 people with CFRD, with a prevalence of 40% in adults with CF and 1% in adolescents. Among them, 7% used insulin pumps, 41% used basal-bolus treatment, 11% used only basal or mixed insulin, 6% used only bolus insulin, 33% did not use insulin or oral antidiabetics, and 2% used combinations or had missing data on treatment regimen. Median HbA1c was 48 mmol/mol, with 10% having HbA1c >/= 70 mmol/mol. Continuous glucose monitoring (CGM) users (44%) had a median time in range of 70% and median time below range of 1%. No cases of severe hypoglycemia were recorded in the year before data collection. CONCLUSIONS: In the Danish CFRD cohort glycemic control was generally good, although some remained severely dysregulated. While insulin remains the only antidiabetic treatment, the role of oral antidiabetics is likely to expand in the post-modulator era. CI - (c) 2026 The Author(s). Pediatric Pulmonology published by Wiley Periodicals LLC. FAU - Grimsgaard, Ingrid AU - Grimsgaard I AUID- ORCID: 0009-0008-0334-5908 AD - Department of Infectious Diseases, Cystic Fibrosis Center Copenhagen, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark. FAU - Henriksen, Esben Herborg AU - Henriksen EH AD - Department of Infectious Diseases, Cystic Fibrosis Center Copenhagen, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark. FAU - Nielsen, Bibi Uhre AU - Nielsen BU AD - Department of Infectious Diseases, Cystic Fibrosis Center Copenhagen, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark. FAU - Faurholt-Jepsen, Daniel AU - Faurholt-Jepsen D AUID- ORCID: 0000-0001-8561-0155 AD - Department of Infectious Diseases, Cystic Fibrosis Center Copenhagen, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark. AD - Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark. FAU - Jeppesen, Majbritt AU - Jeppesen M AD - Department of Infectious Diseases, Cystic Fibrosis Center Aarhus, Aarhus University Hospital, Aarhus, Denmark. FAU - Almdal, Thomas AU - Almdal T AD - Department of Endocrinology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. FAU - Sondergaard, Esben AU - Sondergaard E AD - Steno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, Denmark. LA - eng PT - Journal Article PL - United States TA - Pediatr Pulmonol JT - Pediatric pulmonology JID - 8510590 RN - 0 (Hypoglycemic Agents) RN - 0 (Insulin) RN - 0 (Glycated Hemoglobin) RN - 0 (Blood Glucose) RN - 0 (hemoglobin A1c protein, human) SB - IM MH - Humans MH - Denmark/epidemiology MH - Cross-Sectional Studies MH - *Cystic Fibrosis/complications/epidemiology MH - Female MH - Male MH - Adolescent MH - Adult MH - *Diabetes Mellitus/drug therapy/etiology/epidemiology MH - *Hypoglycemic Agents/therapeutic use/administration & dosage MH - *Insulin/therapeutic use/administration & dosage MH - Glycated Hemoglobin/metabolism/analysis MH - Child MH - Young Adult MH - Continuous Glucose Monitoring MH - Prevalence MH - Child, Preschool MH - Registries MH - Blood Glucose MH - Middle Aged PMC - PMC12926720 OTO - NOTNLM OT - cross-sectional study OT - cystic fibrosis OT - cystic fibrosis-related diabetes OT - quality of care COIS- Thomas Almdal holds stocks in Novo Nordisk. The other authors declare no conflicts of interest. EDAT- 2026/02/23 06:27 MHDA- 2026/02/23 06:28 PMCR- 2026/02/23 CRDT- 2026/02/23 02:43 PHST- 2025/11/26 00:00 [revised] PHST- 2025/04/30 00:00 [received] PHST- 2026/02/17 00:00 [accepted] PHST- 2026/02/23 06:28 [medline] PHST- 2026/02/23 06:27 [pubmed] PHST- 2026/02/23 02:43 [entrez] PHST- 2026/02/23 00:00 [pmc-release] AID - PPUL71533 [pii] AID - 10.1002/ppul.71533 [doi] PST - ppublish SO - Pediatr Pulmonol. 2026 Feb;61(2):e71533. doi: 10.1002/ppul.71533. PMID- 41725310 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1097-0258 (Electronic) IS - 0277-6715 (Print) IS - 0277-6715 (Linking) VI - 45 IP - 3-5 DP - 2026 Feb TI - Modelling and Predicting Population-Level Growth With Individual-Level Information. PG - e70421 LID - 10.1002/sim.70421 [doi] LID - e70421 AB - The development of height, weight, and body mass index (BMI) in children has been the subject of considerable interest due to secular changes in growth patterns, such as increases in height and rising obesity rates. Predicting growth in a target population is particularly challenging when the population comprises of individuals with and without past growth data. In this study, we present three approaches for the joint prediction of height and weight in that situation. The predictive performance of each approach is evaluated using a range of measures that assess different properties of the prediction distributions. We also compare the approaches to interpret their clinical relevance, particularly in terms of prediction accuracy. The developed prediction approaches vary in their use of past growth data. We predict growth for a target population of children aged 4-11 years in 2021, residing in three municipalities in Finland. We employ longitudinal register data on height and weight, collected from children aged 2-11 years between 2014 and 2020 in these municipalities to construct a Bayesian hierarchical linear model (HLM) for growth prediction. Additionally, we estimate posterior unconditional distributions of height, weight, and BMI for within-sample model validation. The inclusion of individual-level data in the predictions reduced the divergence from observed measurements, particularly for weight and BMI. This is important given the skewed distribution of the measurements with increasing age. Incorporating individual-level information is also beneficial for child-specific predictions. Our study highlights the importance of multiple prediction checks to understand the flaws and strengths of each prediction approach. CI - (c) 2026 The Author(s). Statistics in Medicine published by John Wiley & Sons Ltd. FAU - Kauppala, Tuuli AU - Kauppala T AUID- ORCID: 0009-0004-1233-0055 AD - Department of Data and Analytics, Finnish Institute for Health and Welfare, Helsinki, Finland. AD - Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland. FAU - Susi, Tuomo AU - Susi T AD - Department of Data and Analytics, Finnish Institute for Health and Welfare, Helsinki, Finland. AD - Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland. FAU - Kulathinal, Sangita AU - Kulathinal S AUID- ORCID: 0000-0002-4542-8460 AD - Department of Mathematics and Statistics, University of Helsinki, Helsinki, Finland. LA - eng PT - Journal Article PL - England TA - Stat Med JT - Statistics in medicine JID - 8215016 SB - IM MH - Humans MH - Child, Preschool MH - Child MH - Bayes Theorem MH - Body Mass Index MH - *Body Height MH - *Body Weight MH - Finland MH - Linear Models MH - *Models, Statistical MH - Female MH - Male MH - Prediction Algorithms MH - *Population Growth MH - Longitudinal Studies PMC - PMC12926727 OTO - NOTNLM OT - Bayesian prediction OT - bivariate hierarchical model OT - growth modeling OT - growth prediction OT - hierarchical linear model COIS- The authors declare no conflicts of interest. EDAT- 2026/02/23 06:27 MHDA- 2026/02/23 06:28 PMCR- 2026/02/23 CRDT- 2026/02/23 02:43 PHST- 2025/12/12 00:00 [revised] PHST- 2025/01/28 00:00 [received] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/02/23 06:28 [medline] PHST- 2026/02/23 06:27 [pubmed] PHST- 2026/02/23 02:43 [entrez] PHST- 2026/02/23 00:00 [pmc-release] AID - SIM70421 [pii] AID - 10.1002/sim.70421 [doi] PST - ppublish SO - Stat Med. 2026 Feb;45(3-5):e70421. doi: 10.1002/sim.70421. PMID- 41724965 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260627 LR - 20260813 IS - 1743-7075 (Print) IS - 1743-7075 (Electronic) IS - 1743-7075 (Linking) VI - 23 IP - 1 DP - 2026 Feb 22 TI - Skin carotenoids indicate diet, serum carotenoids, and inflammation across obesity and metabolic status in children. LID - 10.1186/s12986-026-01075-7 [doi] LID - 41 AB - OBJECTIVES: To validate reflection spectroscopy (RS)-based skin carotenoids (SCS) as non-invasive biomarkers of fruit and vegetable intake (FVI) in children and adolescents with obesity and metabolic dysfunction. METHODS: This case-control study (China, 2023) included 210 children and adolescents aged 7-17 years, categorized into five groups: healthy weight (n = 30), overweight (n = 23), obesity (n = 25), obesity with one metabolic disorder (n = 56), and obesity with two or more metabolic disorders (n = 76). SCS levels were measured using RS, FVI was assessed via a food frequency questionnaire, serum carotenoids were quantified by high-performance liquid chromatography, and inflammatory markers were analyzed using flow cytometry. RESULTS: SCS and serum carotenoid levels decreased significantly across groups (p for trend < 0.001). SCS correlated strongly with serum carotenoids, except for lycopene, with the strongest association observed in children and adolescents with obesity and two or more metabolic disorders. A quartile increase in FVI resulted in an 11.92-45.98 unit increase in SCS, partially mediated by total serum carotenoids, beta-carotene, and beta-cryptoxanthin. SCS also inversely correlated with inflammation in metabolically disordered groups. CONCLUSIONS: RS-based SCS is a valid, non-invasive biomarker of FVI, closely related to serum carotenoids and inflammatory status, and effectively distinguishes metabolic dysfunction in children and adolescents. FAU - Liu, Yang AU - Liu Y AD - Health Sciences Institute, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China. AD - Liaoning Key Laboratory of Obesity and Glycolipid Metabolic Diseases, Puhe Rd.77, Shenyang, 110122, Liaoning, China. FAU - Huang, Huihui AU - Huang H AD - Health Sciences Institute, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China. AD - Liaoning Key Laboratory of Obesity and Glycolipid Metabolic Diseases, Puhe Rd.77, Shenyang, 110122, Liaoning, China. FAU - Sun, Chi AU - Sun C AD - Experiment Center of Science, China Medical University, Puhe Rd.77, Shenyang, 110122, Liaoning, China. FAU - Jia, Wenhan AU - Jia W AD - Health Sciences Institute, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China. AD - Liaoning Key Laboratory of Obesity and Glycolipid Metabolic Diseases, Puhe Rd.77, Shenyang, 110122, Liaoning, China. FAU - Zhuang, Xuxiu AU - Zhuang X AD - Health Sciences Institute, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China. AD - Liaoning Key Laboratory of Obesity and Glycolipid Metabolic Diseases, Puhe Rd.77, Shenyang, 110122, Liaoning, China. FAU - Zheng, Jia AU - Zheng J AD - Health Sciences Institute, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China. AD - Liaoning Key Laboratory of Obesity and Glycolipid Metabolic Diseases, Puhe Rd.77, Shenyang, 110122, Liaoning, China. FAU - Jiang, Le AU - Jiang L AD - Health Sciences Institute, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China. AD - Liaoning Key Laboratory of Obesity and Glycolipid Metabolic Diseases, Puhe Rd.77, Shenyang, 110122, Liaoning, China. FAU - Ma, Yanan AU - Ma Y AD - Liaoning Key Laboratory of Obesity and Glycolipid Metabolic Diseases, Puhe Rd.77, Shenyang, 110122, Liaoning, China. AD - School of Public Health, China Medical University, Puhe Rd.77, Shenyang, 110122, Liaoning, China. FAU - Song, Bing AU - Song B AD - First Affiliated Hospital of Jinzhou Medical University, 2-5 Renmin Road, Jinzhou, 121001, China. FAU - Gittelsohn, Joel AU - Gittelsohn J AD - Department of International Health, Human Nutrition Center, Johns Hopkins Bloomberg School of Public Health, 615 North Wolfe St Baltimore, Baltimore, MD, 21205-2179, USA. FAU - Wen, Deliang AU - Wen D AD - Health Sciences Institute, China Medical University, No.77 Puhe Road, Shenyang North New Area, Shenyang, 110122, Liaoning, China. dlwen@cmu.edu.cn. AD - Liaoning Key Laboratory of Obesity and Glycolipid Metabolic Diseases, Puhe Rd.77, Shenyang, 110122, Liaoning, China. dlwen@cmu.edu.cn. LA - eng GR - 72174208/National Natural Science Foundation of China/ GR - D21008/the 111 project/ PT - Journal Article DEP - 20260222 PL - England TA - Nutr Metab (Lond) JT - Nutrition & metabolism JID - 101231644 PMC - PMC13032390 OTO - NOTNLM OT - Biomarkers OT - Fruit and vegetable intake OT - Metabolic dysfunction OT - Obesity OT - Skin carotenoids COIS- Declarations. Ethics approval and consent to participate: Signed informed consent was obtained from the participating children and their parents or legal guardians.The study was approved by Ethics Committee of China Medical University (Approval No: Ethics Review [2021] 124). Competing interests: The authors declare no competing interests. EDAT- 2026/02/23 01:34 MHDA- 2026/02/23 01:35 PMCR- 2026/02/22 CRDT- 2026/02/22 23:23 PHST- 2025/06/11 00:00 [received] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/02/23 01:35 [medline] PHST- 2026/02/23 01:34 [pubmed] PHST- 2026/02/22 23:23 [entrez] PHST- 2026/02/22 00:00 [pmc-release] AID - 10.1186/s12986-026-01075-7 [pii] AID - 1075 [pii] AID - 10.1186/s12986-026-01075-7 [doi] PST - epublish SO - Nutr Metab (Lond). 2026 Feb 22;23(1):41. doi: 10.1186/s12986-026-01075-7. PMID- 41724959 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Feb 23 TI - Predicting failed trial of labor in advanced-age primiparas: development and validation of a clinical nomogram. LID - 10.1186/s12884-026-08794-y [doi] LID - 347 AB - BACKGROUND: With rising rates of delayed childbearing in China, clinical decision-making for advanced-age primiparas (>/= 35 years) is challenging, often leading to unnecessary cesarean sections or failed labor trials. This study aimed to develop and validate a model to predict labor failure risk in term, singleton, cephalic-presenting advanced-age primiparas. METHODS: A retrospective cohort of 1344 women from Peking University First Hospital (October 2019-September 2022) was used for model development. Predictors were selected using least absolute shrinkage and selection operator (LASSO) regression, followed by multivariable logistic regression to construct the final model. Model performance was assessed by area under the receiver operating characteristic curve (AUC), calibration plots, and decision curve analysis. Internal validation was performed with 1000‑sample bootstrapping, and external validation was conducted on an independent cohort of 601 women from the Daxing Branch (May 2024-April 2025). RESULTS: The trial of labor success rates were 67.4% and 71.0% in the development and validation cohorts, respectively. Eleven predictors were identified: increased gestational weight gain, higher pre-pregnancy BMI, advanced gestational age, estimated fetal weight >/= 4.0 kg, maternal anemia, abnormal amniotic fluid volume, premature rupture of membranes, hypertensive disorders, and labor induction were risk factors; greater maternal height and epidural analgesia were protective. The model showed good discrimination with an AUC of 0.751 in the development cohort, remained stable at 0.741 after internal validation, and achieved 0.759 in external validation, indicating strong generalizability. Calibration plots demonstrated good agreement between predicted and observed outcomes, and decision curve analysis confirmed clinical utility. CONCLUSIONS: This validated prediction model effectively identifies high-risk advanced-age primiparas, aiding delivery mode counseling and personalized care. Prioritizing gestational weight control, anemia correction, and epidural analgesia could improve vaginal birth rates and optimize outcomes. FAU - Nian, Songwen AU - Nian S AD - Department of Obstetrics and Gynecology, Peking University First Hospital, No. 1 Xi'anmen Street, Beijing, 100034, China. FAU - Wei, Yumei AU - Wei Y AD - Department of Obstetrics and Gynecology, Peking University First Hospital, No. 1 Xi'anmen Street, Beijing, 100034, China. weiyumei1982@126.com. LA - eng GR - 2025YFC2708303/National Key Research and Development Program of China/ GR - G202522093/The Beijing High-Level Innovation and Entrepreneurship Talent Support Program-Healthcare Platform talent projects/young backbone/ GR - 25cz020301-4803102/National High Level Hospital Clinical Research Funding (Scientific Research Fund of Peking University First Hospital)/ PT - Journal Article PT - Validation Study DEP - 20260223 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - *Nomograms MH - Pregnancy MH - Retrospective Studies MH - *Trial of Labor MH - Adult MH - China MH - Advanced Maternal Age MH - Parity MH - Prediction Algorithms MH - Risk Factors PMC - PMC13036918 OTO - NOTNLM OT - Advanced-age primipara OT - Cesarean section OT - Nomogram OT - Prediction model OT - Trial of labor COIS- Declarations. Ethics approval and consent to participate: This study was performed in accordance with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Peking University First Hospital in China (No. 2013 - 572). Given the retrospective nature of this study, informed consent was not needed from the women included in the analysis. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/23 01:34 MHDA- 2026/06/28 00:38 PMCR- 2026/02/23 CRDT- 2026/02/22 23:23 PHST- 2025/10/28 00:00 [received] PHST- 2026/02/06 00:00 [accepted] PHST- 2026/06/28 00:38 [medline] PHST- 2026/02/23 01:34 [pubmed] PHST- 2026/02/22 23:23 [entrez] PHST- 2026/02/23 00:00 [pmc-release] AID - 10.1186/s12884-026-08794-y [pii] AID - 8794 [pii] AID - 10.1186/s12884-026-08794-y [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Feb 23;26(1):347. doi: 10.1186/s12884-026-08794-y. PMID- 41724484 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260708 IS - 1525-3198 (Electronic) IS - 0022-0302 (Linking) VI - 109 IP - 5 DP - 2026 May TI - Trace-level ultra-high-performance liquid chromatography-tandem mass spectrometry detection of organophosphorus pesticides in camel milk: Safeguarding public health. PG - 5019-5027 LID - S0022-0302(26)00159-1 [pii] LID - 10.3168/jds.2025-27890 [doi] AB - Camel milk is renowned for its nutritional and medicinal properties, yet its potential contamination remains a growing public concern. Despite this, the organophosphorus pesticide (OPP) content of camel milk has not been comprehensively analyzed worldwide. Using liquid chromatography-tandem mass spectrometry, we analyzed 12 important OPP in 40 camel milk samples over a widespread distribution in the United Arab Emirates. Both raw and pasteurized milk samples were analyzed, and the method was validated under international guidelines. The method achieves high accuracy, precision, and linearity (R(2) >/= 0.991) and low limits of detection (1.09-1.51 microg/kg) and quantification (3.61-4.99 microg/kg). The OPP concentrations varied among the analyzed samples. Chlorpyrifos, phorate, and diazinon were detected above their respective maximum residue limits in 7.5%, 2.5%, and 2.5% of the analyzed samples, respectively. According to the health-risk assessment findings, camel milk consumption may pose a potential health concern for the consumers in the affected region. These findings can inform forthcoming developments in dairy science and underscore the importance of thorough assessments of OPP in camel milk, which is regularly consumed by adults, children, and infants. CI - The Authors. Published by Elsevier Inc. on behalf of the American Dairy Science Association(R). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). FAU - Usman, Muhammad AU - Usman M AD - Chemistry Department, College of Science, United Arab Emirates University, Al-Ain, P. O. Box 15551, United Arab Emirates. FAU - Hakeem, Muhammad Kamran AU - Hakeem MK AD - Chemistry Department, College of Science, United Arab Emirates University, Al-Ain, P. O. Box 15551, United Arab Emirates. FAU - Askar, Shaima AU - Askar S AD - Chemistry Department, College of Science, United Arab Emirates University, Al-Ain, P. O. Box 15551, United Arab Emirates. FAU - Shah, Iltaf AU - Shah I AD - Chemistry Department, College of Science, United Arab Emirates University, Al-Ain, P. O. Box 15551, United Arab Emirates; Khalifa Center for Genetic Engineering and Biotechnology, United Arab Emirates University, Al-Ain, P. O. Box 15551, United Arab Emirates. FAU - Rajendran, Tamilarasan AU - Rajendran T AD - Khalifa Center for Genetic Engineering and Biotechnology, United Arab Emirates University, Al-Ain, P. O. Box 15551, United Arab Emirates. FAU - Ghoudi, Kilani AU - Ghoudi K AD - Department of Statistics, College of Business and Economics, United Arab Emirates University, Al-Ain, P. O. Box 15551, United Arab Emirates. FAU - Meetani, Mohammed A AU - Meetani MA AD - Chemistry Department, College of Science, United Arab Emirates University, Al-Ain, P. O. Box 15551, United Arab Emirates. Electronic address: mmeetani@uaeu.ac.ae. LA - eng PT - Journal Article DEP - 20260220 PL - United States TA - J Dairy Sci JT - Journal of dairy science JID - 2985126R RN - 0 (Organophosphorus Compounds) RN - 0 (Pesticide Residues) SB - IM MH - Animals MH - *Milk/chemistry MH - *Tandem Mass Spectrometry/methods MH - Camelus MH - Chromatography, High Pressure Liquid/methods MH - *Organophosphorus Compounds/analysis MH - *Food Contamination/analysis MH - Liquid Chromatography-Mass Spectrometry MH - *Pesticide Residues/analysis MH - United Arab Emirates MH - Public Health OTO - NOTNLM OT - UHPLC-MS/MS OT - camel milk OT - health-risk assessment OT - organophosphorus pesticides OT - pesticides EDAT- 2026/02/23 01:34 MHDA- 2026/04/28 00:33 CRDT- 2026/02/22 19:30 PHST- 2025/11/05 00:00 [received] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/04/28 00:33 [medline] PHST- 2026/02/23 01:34 [pubmed] PHST- 2026/02/22 19:30 [entrez] AID - S0022-0302(26)00159-1 [pii] AID - 10.3168/jds.2025-27890 [doi] PST - ppublish SO - J Dairy Sci. 2026 May;109(5):5019-5027. doi: 10.3168/jds.2025-27890. Epub 2026 Feb 20. PMID- 41724198 OWN - NLM STAT- MEDLINE DCOM- 20260603 LR - 20260629 IS - 1531-5053 (Electronic) IS - 0278-2391 (Linking) VI - 84 IP - 6 DP - 2026 Jun TI - Stereophotogrammetry as a Precise and Accurate Method for Facial Analysis in Patients With Cleft Lip and Palate Undergoing Orthognathic Surgery. PG - 859-868 LID - S0278-2391(26)00067-4 [pii] LID - 10.1016/j.joms.2026.01.073 [doi] AB - BACKGROUND: Stereophotogrammetry is a promising tool for orthognathic surgical planning. However, its application in patients with cleft lip and palate (CLP) still requires validation. PURPOSE: The objective of this study was to evaluate the accuracy and precision of portable stereophotogrammetry system (PSP) in facial analysis of patients with CLP. STUDY DESIGN, SETTING, AND SAMPLE: This is a cross-sectional study with patients with nonsyndromic CLP and skeletal Class III. Exclusion criteria included syndromic CLP, facial hair, mustaches, absence of the right upper central incisor, or use of facial prosthetics. The study was conducted at the Hospital for Rehabilitation of Craniofacial Anomalies, Bauru, Brazil. PREDICTOR VARIABLES: The predictor variable was the facial measurement method, PSP, or digital caliper. OUTCOME VARIABLES: The primary outcome was accuracy, assessed by comparing PSP measurements with those obtained by digital calipers and categorized as excellent (<1.0 mm), good (1.0 to 2.0 mm), moderate (2.0 to 3.0 mm), or unsatisfactory (>3.0 mm). The secondary outcome was precision, evaluated through mean absolute deviation (MAD) and mean relative error (MRE). MAD used the same thresholds as accuracy, while MRE was classified as excellent (<3%), good (3 to 5%), moderate (5 to 10%), or unsatisfactory (>10%). COVARIATES: The covariates included age, sex, and the type of cleft (complete unilateral or bilateral). ANALYSES: Statistical tests were applied based on data distribution (Shapiro-Wilk, Student's t test, and Mann-Whitney U test), with the significance level set at P < .05. RESULTS: The sample comprised 11 subjects with a mean age of 23.0 years (+/-6.43); 6 (54.5%) were male. Regarding accuracy, 6 of 15 measurements were classified as excellent, 2 as good, and 3 as moderate. Four were unsatisfactory: Al-Al (6.04 mm), Sti-Me (5.81 mm), Me-C (9.03 mm), and UR1s (3.83 mm). Regarding precision, 13 (86.7%) measurements showed excellent MAD values, whereas MRE indicated excellent or good precision in 8 measurements (53.3%). CONCLUSIONS AND RELEVANCE: The results indicate that the PSP achieves acceptable levels of accuracy and precision for facial analysis in patients with CLP and can be integrated with other technologies for 3-dimensional planning. CI - Copyright (c) 2026 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved. FAU - Mariotto, Ligia Gabrielle Sanches AU - Mariotto LGS AD - Private Practitioner, Oral and Maxillofacial Surgery Division, Hospital for Rehabilitation of Craniofacial Anomalies, University of Sao Paulo, Bauru, Sao Paulo, Brazil. Electronic address: mariotto.ligia@gmail.com. FAU - Reis de Araujo Carvalho, Luciano AU - Reis de Araujo Carvalho L AD - PhD Candidate, Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of Sao Paulo, Bauru, Sao Paulo, Brazil. FAU - de Paula Oliveira Gringo, Caroline AU - de Paula Oliveira Gringo C AD - Postdoctoral Researcher, Department of Stomatology, Radiology and Imaging, Bauru School of Dentistry, University of Sao Paulo, Bauru, Sao Paulo, Brazil. FAU - Faria Yaedu, Renato Yassutaka AU - Faria Yaedu RY AD - Professor, Department of Surgery, Stomatology, Pathology and Radiology, Bauru School of Dentistry, University of Sao Paulo, Bauru, Sao Paulo, Brazil. LA - eng PT - Journal Article DEP - 20260210 PL - United States TA - J Oral Maxillofac Surg JT - Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons JID - 8206428 SB - IM MH - Humans MH - *Photogrammetry/methods MH - *Cleft Palate/surgery/diagnostic imaging MH - *Cleft Lip/surgery/diagnostic imaging MH - Cross-Sectional Studies MH - Female MH - Male MH - *Orthognathic Surgical Procedures/methods MH - Adolescent MH - *Face/anatomy & histology/diagnostic imaging MH - Reproducibility of Results MH - Young Adult MH - Adult MH - Cephalometry EDAT- 2026/02/23 01:34 MHDA- 2026/06/03 18:36 CRDT- 2026/02/22 19:21 PHST- 2025/05/21 00:00 [received] PHST- 2026/01/12 00:00 [revised] PHST- 2026/01/25 00:00 [accepted] PHST- 2026/06/03 18:36 [medline] PHST- 2026/02/23 01:34 [pubmed] PHST- 2026/02/22 19:21 [entrez] AID - S0278-2391(26)00067-4 [pii] AID - 10.1016/j.joms.2026.01.073 [doi] PST - ppublish SO - J Oral Maxillofac Surg. 2026 Jun;84(6):859-868. doi: 10.1016/j.joms.2026.01.073. Epub 2026 Feb 10. PMID- 41723458 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1824-7288 (Electronic) IS - 1720-8424 (Linking) VI - 52 IP - 1 DP - 2026 Feb 21 TI - Clinical and biochemical evaluation of children with short stature in the primary care setting: a systematic review. LID - 10.1186/s13052-026-02215-8 [doi] LID - 47 AB - Short stature is a frequent reason for pediatric referral, yet clear diagnostic criteria remain elusive. Variability in clinical definitions, reference growth charts, and laboratory screening tests complicates the evaluation of affected children. This systematic review aimed to analyze the diagnostic approaches used in clinical and biochemical assessments of short stature in children in the primary care setting. This systematic review was conducted in accordance with PRISMA 2020 guidelines and registered in PROSPERO (CRD420251002215). Two independent literature searches were performed to address two domains: clinical and biochemical assessment. Studies were selected based on predefined inclusion and exclusion criteria, and risk of bias was assessed using the JBI critical appraisal tools. All procedures were conducted by independent reviewers, and discrepancies were resolved by consensus or through a third reviewer. A total of 424 studies were included, 35 in the clinical and 7 in the biochemical domain. Definitions of short stature considered in the studies varied considerably: 28 studies used a threshold of < 2 standard deviation score, while 19 applied percentile-based cut-offs (mostly the 3rd percentile); 8 studies considered both definitions, 3 studies do not report any definition. Growth velocity and target height were rarely used, despite their diagnostic value. Local growth charts were employed when available; otherwise, WHO and CDC references were most used. Laboratory assessments also varied greatly, with complete blood count and urine/stool analyses commonly performed, while thyroid function and celiac disease screening were inconsistently applied. There is substantial heterogeneity in the clinical and biochemical evaluation of children with short stature across studies. This reflects the absence of universally accepted diagnostic criteria and standardized screening protocols. These findings emphasize the need for internationally accepted, evidence-based guidelines to improve diagnostic accuracy and clinical management of children with short stature. CI - (c) 2026. The Author(s). FAU - Mameli, Chiara AU - Mameli C AUID- ORCID: 0000-0002-6768-3411 AD - Department of Pediatrics, Vittore Buzzi Children's Hospital, Universita di Milano, Milan, Italy. chiara.mameli@unimi.it. AD - Department of Biomedical and Clinical Science, Universita di Milano, Milan, Italy. chiara.mameli@unimi.it. FAU - Agostiniani, Rino AU - Agostiniani R AD - Department of Pediatrics, San Jacopo Hospital, Pistoia, Italy. FAU - Banderali, Giuseppe AU - Banderali G AD - Department of Pediatrics ASST Santi Paolo e Carlo Hospital, Department of Health Science, Universita di Milano, Milan, Italy. FAU - Bozzola, Elena AU - Bozzola E AD - Pediatric Unit, IRCCS Bambino Gesu Children Hospital, Rome, Italy. FAU - Di Stefano, Vita Antonella AU - Di Stefano VA AD - Department of Pediatrics, Azienda Ospedaliera per l'Emergenza Cannizzaro, Catania, Italy. FAU - Greco, Luigi AU - Greco L AD - General Pediatrician, ASST Papa Giovanni XXIII - Bergamo, Bergamo, Italy. FAU - Pecoraro, Carmine AU - Pecoraro C AD - Pediatric Nephrology and Dialysis Unit, A.O.R.N. Santobono Pausilipon Children's Hospital, Naples, Italy. FAU - Rugolotto, Simone AU - Rugolotto S AD - Division of Pediatrics and Neonatology, Department of Maternal Infant Medicine, Santa Maria della Misericordia Hospital, Rovigo, Italy. FAU - Sollai, Sara AU - Sollai S AD - Department of Pediatrics, Santa Maria Annunziata Hospital, Florence, Italy. FAU - Verduci, Elvira AU - Verduci E AD - Department of Health Sciences, University of Milano, Milano, Italy. AD - Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy. FAU - Guadagni, Liliana AU - Guadagni L AD - Department of Surgical and Biomedical Sciences, University of Perugia, Perugia, Italy. FAU - Giudice, Claudio Lo AU - Giudice CL AD - C.R.E.A. Sanita (Centre for Applied Economic Research in Healthcare), Rome, Italy. FAU - Caforio, Gaetano AU - Caforio G AD - C.R.E.A. Sanita (Centre for Applied Economic Research in Healthcare), Rome, Italy. FAU - Staiano, Annamaria AU - Staiano A AD - Department of Translational Medical Sciences-Section of Pediatrics, University of Naples "Federico II", Naples, Italy. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260221 PL - England TA - Ital J Pediatr JT - Italian journal of pediatrics JID - 101510759 SB - IM MH - Humans MH - *Growth Disorders/diagnosis MH - *Primary Health Care MH - Child MH - *Body Height PMC - PMC13032349 COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: All the authors gave their consent for publication. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/02/22 05:35 MHDA- 2026/03/28 06:40 PMCR- 2026/02/21 CRDT- 2026/02/21 23:36 PHST- 2025/05/07 00:00 [received] PHST- 2026/02/08 00:00 [accepted] PHST- 2026/03/28 06:40 [medline] PHST- 2026/02/22 05:35 [pubmed] PHST- 2026/02/21 23:36 [entrez] PHST- 2026/02/21 00:00 [pmc-release] AID - 10.1186/s13052-026-02215-8 [pii] AID - 2215 [pii] AID - 10.1186/s13052-026-02215-8 [doi] PST - epublish SO - Ital J Pediatr. 2026 Feb 21;52(1):47. doi: 10.1186/s13052-026-02215-8. PMID- 41723384 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 26 IP - 1 DP - 2026 Feb 21 TI - The effect of active virtual reality gaming on physical activity behaviour and mental health in young men with mild to moderate depressive symptoms: a randomised controlled feasibility trial. LID - 10.1186/s12888-026-07904-6 [doi] LID - 269 AB - BACKGROUND: Physical activity (PA) benefits mental health, yet uptake and adherence are challenging, particularly for those affected by depression. Active virtual reality gaming (AVRG) may provide an engaging route to increase PA. OBJECTIVE: To investigate the feasibility and acceptability of AVRG for increasing PA engagement and adherence in young men, and to explore effects on mental-health-related outcomes. METHODS: In a randomised controlled feasibility trial (n = 30), physically inactive males aged 18-29, reporting mild to moderate depressive symptoms were allocated to Active AVRG (n = 14) or Waitlist (WL) control (n = 16). The intervention ran for 8 weeks with a 4-week post-trial follow-up. Exploratory analysis of secondary outcomes compared pre- and post-AVRG scores using paired t-test (normal), or Wilcoxon Signed-Rank test (non-normal); correlations used Pearson's or Spearman's coefficients. RESULTS: Both the feasibility and acceptability criteria were met with 67% of potentially eligible participants, and 100% of those who booked phone screening randomised and enrolled. Retention was high, with 93.3% completing the study, and 87.5% completing all data collection measures. Exploratory analysis of secondary outcomes, showed a significant reduction in both Patient Health Questionnaire- 9 (PHQ-9) scores mean difference (MD) -2.82, (p = 0.006) and Depression, Anxiety and Stress Scale- 21 (DASS-21) stress scores MD -3.56 (p = 0.049) over the intervention period, as well as a very strong (p = 0.001) negative correlation (r =-0.57) between PHQ-9 score and number of sessions, a strong (p = 0.01) negative correlation between PHQ-9 and number of sessions > 30 mins. In addition, a moderate (p = 0.03) negative correlation (r =-0.43) was found between post-intervention DASS-21 Depression score and number of sessions > 30 mins. PA increased over the course of the intervention with none of the participants meeting the Australian National PA Guidelines at baseline, increasing to 50% at end of trial. CONCLUSIONS: This study found that a home-based AVRG intervention was feasible, acceptable, and safe for young men with mild-moderate depressive symptoms, with high recruitment, retention, and adherence. Exploratory findings indicate improvements in PA and favourable changes in mental-health measures. These results support progression to a fully powered trial. TRIAL REGISTRATION: This trial was registered with the Australia and New Zealand Clinical Trials Register (approved 22/12/2020, Registration number: ACTRN12620001372976). CI - (c) 2026. The Author(s). FAU - Hargraves, Fiona AU - Hargraves F AD - NICM Health Research Institute, Western Sydney University, Westmead, NSW, Australia. fiona.hargraves@mq.edu.au. AD - Faculty of Medicine, Health and Human Sciences, Macquarie University, Sydney, NSW, Australia. fiona.hargraves@mq.edu.au. FAU - Firth, Joseph AU - Firth J AD - NICM Health Research Institute, Western Sydney University, Westmead, NSW, Australia. AD - Division of Psychology and Mental Health, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK. AD - Greater Manchester Mental Health NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. FAU - George, Emma AU - George E AD - Translational Health Research Institute, School of Medicine, Western Sydney University, Campbelltown, NSW, Australia. AD - School of Health Sciences, Western Sydney University, Campbelltown, NSW, Australia. FAU - MacMillan, Freya AU - MacMillan F AD - Translational Health Research Institute, School of Medicine, Western Sydney University, Campbelltown, NSW, Australia. AD - School of Health Sciences, Western Sydney University, Campbelltown, NSW, Australia. FAU - Garrido, Sandra AU - Garrido S AD - MARCS Institute for Brain, Behaviour & Development, Western Sydney University, Sydney, NSW, Australia. FAU - Sherman, Kerry A AU - Sherman KA AD - Lifespan Health and Wellbeing Research Centre, Macquarie University, Sydney, Australia. AD - School of Psychological Sciences, Macquarie University, Sydney, Australia. FAU - Eathorne, Allie AU - Eathorne A AD - NICM Health Research Institute, Western Sydney University, Westmead, NSW, Australia. AD - Medical Research Institute of New Zealand, NZ, Wellington, New Zealand. FAU - Armour, Mike AU - Armour M AD - NICM Health Research Institute, Western Sydney University, Westmead, NSW, Australia. AD - Medical Research Institute of New Zealand, NZ, Wellington, New Zealand. LA - eng SI - ANZCTR/ACTRN12620001372976 approved 22/12/2020 GR - MR/T021780/1/UK Research and Innovation Future Leaders Fellowship/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20260221 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 SB - IM MH - Humans MH - Male MH - *Depression/therapy/psychology MH - Feasibility Studies MH - Young Adult MH - Adult MH - Adolescent MH - *Video Games/psychology MH - *Virtual Reality MH - *Exercise/psychology MH - *Mental Health PMC - PMC13032570 OTO - NOTNLM OT - COVID-19 trial OT - Depression OT - Digital technology OT - Exercise adherence OT - Health behaviour OT - Mental health OT - Online intervention OT - PA OT - Virtual reality gaming COIS- Declarations. Ethics approval and consent to participate: The Western Sydney University Human Ethics Committee granted approval for this study on 27 November 2020 (H14118). All procedures involving human participants were conducted in accordance with the ethical standards of the institutional research committee and with the Declaration of Helsinki. Informed consent was obtained from all participants prior to participation. This followed the International Conference on Harmonisation Good Clinical Practice Guidelines, local regulatory requirements, and legal requirements. Consent for publication: All authors consent to publication. Competing interests: The authors declare no competing interests. EDAT- 2026/02/22 05:34 MHDA- 2026/03/28 06:40 PMCR- 2026/02/21 CRDT- 2026/02/21 23:34 PHST- 2025/03/03 00:00 [received] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/03/28 06:40 [medline] PHST- 2026/02/22 05:34 [pubmed] PHST- 2026/02/21 23:34 [entrez] PHST- 2026/02/21 00:00 [pmc-release] AID - 10.1186/s12888-026-07904-6 [pii] AID - 7904 [pii] AID - 10.1186/s12888-026-07904-6 [doi] PST - epublish SO - BMC Psychiatry. 2026 Feb 21;26(1):269. doi: 10.1186/s12888-026-07904-6. PMID- 41722366 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260710 IS - 1872-6283 (Electronic) IS - 0379-0738 (Linking) VI - 383 DP - 2026 Jun TI - Inter-population variation in third molar agenesis and its effect on dental age estimation: Evidence from black and white South Africans. PG - 112865 LID - S0379-0738(26)00052-6 [pii] LID - 10.1016/j.forsciint.2026.112865 [doi] AB - Third molar development is widely used for dental age estimation (DAE) in late adolescence and young adulthood; however, agenesis of one or more third molars can compromise its reliability in forensic practice. The prevalence of third molar agenesis is known to vary across population groups, yet its practical impact on forensic age assessment remains insufficiently explored. This study aimed to assess the prevalence and distribution of third molar agenesis in Black South Africans (BSA) and White South Africans (WSA) and to assess its impact on DAE according to sex, tooth position, and birth cohort. A retrospective analysis was conducted on orthopantomograms (OPGs) from 2536 individuals comprising 1688 BSA and 848 WSA. Third molar agenesis was evaluated by tooth position, sex, population group, and birth cohort. Statistical analyses were performed to identify significant intergroup and intragroup differences. Third molar agenesis was significantly more prevalent in WSA (28.42 %) compared to BSA (6.81 %). The overall prevalence of at least one missing third molar was 14.92 % in males and 13.33 % in females. Agenesis occurred slightly more frequently in the maxillary arch (2.48 %) than in the mandibular arch (1.93 %), with no consistent sex- or side-related differences. Birth cohort analysis demonstrated a declining trend in the prevalence of agenesis over time, potentially reflecting demographic and evolutionary influences. The prevalence of third molar agenesis varies significantly between South African population groups, highlighting the influence of genetic ancestry and population-specific factors on dental development. Sole reliance on third molar assessment for DAE may result in inaccurate age estimation, particularly in multi-ethnic populations. Population-specific reference data for third molar development are essential to improve the accuracy and reliability of forensic dental age estimation. Incorporating such data can reduce misclassification and enhance the validity of medico-legal assessments. CI - Copyright (c) 2026 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Angelakopoulos, N AU - Angelakopoulos N AD - Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Bern, Switzerland; Department of Forensic Dentistry, Faculdade Sao Leopoldo Mandic, Campinas, Brazil. Electronic address: nikolaos.angelakopoulos@unibe.ch. FAU - Merdietio Boedi, R AU - Merdietio Boedi R AD - Department of Dentistry, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia. Electronic address: rizkymerdietio@lecturer.undip.ac.id. FAU - Franco, A AU - Franco A AD - Department of Forensic Dentistry, Faculdade Sao Leopoldo Mandic, Campinas, Brazil. Electronic address: ademir.junior@slmandic.edu.br. FAU - De Luca, S AU - De Luca S AD - Department of Organisms and Systems Biology, Faculty of Biology, University of Oviedo, Oviedo, Spain. Electronic address: lucastefano@uniovi.es. LA - eng PT - Journal Article DEP - 20260203 PL - Ireland TA - Forensic Sci Int JT - Forensic science international JID - 7902034 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Male MH - *Molar, Third/diagnostic imaging/abnormalities/growth & development MH - Female MH - South Africa/epidemiology MH - Retrospective Studies MH - Radiography, Panoramic MH - Black People MH - White People MH - Adolescent MH - Southern African People MH - Young Adult MH - Adult MH - *Anodontia/diagnostic imaging/epidemiology MH - Forensic Dentistry MH - Prevalence OTO - NOTNLM OT - Agenesis OT - Dental age estimation OT - Forensic dentistry OT - Population-specific variation OT - South Africa OT - Third molar COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/02/22 05:35 MHDA- 2026/04/04 00:36 CRDT- 2026/02/21 18:07 PHST- 2026/01/21 00:00 [received] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/04/04 00:36 [medline] PHST- 2026/02/22 05:35 [pubmed] PHST- 2026/02/21 18:07 [entrez] AID - S0379-0738(26)00052-6 [pii] AID - 10.1016/j.forsciint.2026.112865 [doi] PST - ppublish SO - Forensic Sci Int. 2026 Jun;383:112865. doi: 10.1016/j.forsciint.2026.112865. Epub 2026 Feb 3. PMID- 41722149 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260708 IS - 1873-376X (Electronic) IS - 1570-0232 (Linking) VI - 1274 DP - 2026 Apr 15 TI - Development and validation of a HILIC-ESI/MS method for quantitation of three oxicams and 5-hydroxypiroxicam in human breast milk. PG - 124973 LID - S1570-0232(26)00062-0 [pii] LID - 10.1016/j.jchromb.2026.124973 [doi] AB - Human breast milk is a complex biological matrix that plays a central role in infant nutrition and development. It may also serve as a route of exposure to pharmaceutical residues following maternal drug use. Quantitative data on the transfer of non-steroidal anti-inflammatory drugs (NSAIDs) into breast milk are essential to support their safe use during lactation, however, available analytical methods remain limited. This study reports the development and validation of a rapid and sensitive hydrophilic interaction liquid chromatography-electrospray ionization mass spectrometry (HILIC-ESI/MS) method for the simultaneous quantitation of tenoxicam, meloxicam, piroxicam, and the metabolite 5'-hydroxypiroxicam in human breast milk. Sample preparation involves simple protein precipitation procedure using only 25 muL of human breast milk. Chromatographic separation is achieved within 8 min. The method was validated over the range of 20 to 2000 ng mL(-1), with a limit of quantitation of 20 ng mL(-1) and correlation coefficients greater than 0.998. This is the first HILIC-ESI/MS method for the simultaneous quantitation of the targeted analytes in human breast milk. The validated HILIC-ESI/MS method was subsequently applied to screen breast milk samples collected from ten lactating women donating to a hospital milk bank. Although oxicam NSAIDs were not detected in this cohort, the method is well-suited for targeted screening of human milk in clinical or surveillance settings, including milk banks and pharmacovigilance studies. CI - Copyright (c) 2024. Published by Elsevier B.V. FAU - Kamperi, Natalia AU - Kamperi N AD - Laboratory of Pharmaceutical Analysis, Faculty of Pharmacy, National and Kapodistrian University of Athens, 157 71 Athens, Greece. FAU - Geballa-Koukoula, Ariadni AU - Geballa-Koukoula A AD - Division of Bioanalytical Chemistry, Department of Chemistry and Pharmaceutical Sciences, AIMMS Amsterdam Institute of Molecular and Life Sciences, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, the Netherlands; Centre for Analytical Sciences Amsterdam, 1098 XH Amsterdam, the Netherlands. FAU - Komninou, Sophia AU - Komninou S AD - Laboratory of Pharmaceutical Analysis, Faculty of Pharmacy, National and Kapodistrian University of Athens, 157 71 Athens, Greece. FAU - Salvanos, Iraklis AU - Salvanos I AD - General-Maternity District Hospital Elena Venizelou, Milk Bank and Maternal Breast-feeding Department, Helena Venizelou Square, 115 21 Athens, Greece. FAU - Ioannou, Ioanna AU - Ioannou I AD - General-Maternity District Hospital Elena Venizelou, Milk Bank and Maternal Breast-feeding Department, Helena Venizelou Square, 115 21 Athens, Greece. FAU - Theiakou, Foteini AU - Theiakou F AD - General-Maternity District Hospital Elena Venizelou, Milk Bank and Maternal Breast-feeding Department, Helena Venizelou Square, 115 21 Athens, Greece. FAU - Panderi, Irene AU - Panderi I AD - Laboratory of Pharmaceutical Analysis, Faculty of Pharmacy, National and Kapodistrian University of Athens, 157 71 Athens, Greece. Electronic address: irenepanderi@gmail.com. LA - eng PT - Journal Article DEP - 20260218 PL - Netherlands TA - J Chromatogr B Analyt Technol Biomed Life Sci JT - Journal of chromatography. B, Analytical technologies in the biomedical and life sciences JID - 101139554 RN - 0 (Anti-Inflammatory Agents, Non-Steroidal) RN - 13T4O6VMAM (Piroxicam) SB - IM MH - Humans MH - *Milk, Human/chemistry MH - *Spectrometry, Mass, Electrospray Ionization/methods MH - *Liquid Chromatography-Mass Spectrometry/methods MH - Reproducibility of Results MH - Hydrophobic and Hydrophilic Interactions MH - Female MH - *Anti-Inflammatory Agents, Non-Steroidal/analysis MH - Limit of Detection MH - *Piroxicam/analysis/analogs & derivatives MH - Linear Models OTO - NOTNLM OT - Breast milk OT - HILIC OT - LC-MS OT - NSAIDs OT - Oxicams OT - Protein precipitation COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/02/22 05:35 MHDA- 2026/03/13 00:50 CRDT- 2026/02/21 18:02 PHST- 2026/01/02 00:00 [received] PHST- 2026/01/28 00:00 [revised] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/03/13 00:50 [medline] PHST- 2026/02/22 05:35 [pubmed] PHST- 2026/02/21 18:02 [entrez] AID - S1570-0232(26)00062-0 [pii] AID - 10.1016/j.jchromb.2026.124973 [doi] PST - ppublish SO - J Chromatogr B Analyt Technol Biomed Life Sci. 2026 Apr 15;1274:124973. doi: 10.1016/j.jchromb.2026.124973. Epub 2026 Feb 18. PMID- 41721812 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260920 IS - 1097-6752 (Electronic) IS - 0889-5406 (Print) IS - 0889-5406 (Linking) VI - 169 IP - 6 DP - 2026 Jun TI - Automated artificial intelligence-driven 3-dimensional craniofacial superimposition for clinically useful treatment outcomes in growing patients: A multicenter study. PG - 753-765 LID - S0889-5406(26)00033-8 [pii] LID - 10.1016/j.ajodo.2025.12.013 [doi] AB - INTRODUCTION: In growing patients, reliable quantification of change requires explicitly stating the reference used for superimposition and interpreting all values as relative changes; however, manual workflows are time-consuming and variable. This study assessed measurement reliability and workflow efficiency for reference-explicit analyses, comparing a fully automated, open-source segmentation and registration workflow against a semiautomatic voxel-based approach for clinically useful 3-dimensional assessments. METHODS: Twenty-two Class II patients with cone-beam computed tomographies at pretreatment (T1) and posttreatment (T2) were analyzed. Automated segmentation and voxel-based superimposition were performed with built-in quantitative analysis. Primary outcomes were skeletal and dental changes relative to cranial base and regional maxilla and mandibular superimposition. Three registration approaches incorporating varying levels of artificial intelligence (AI) involvement-conventional, semiautomated, and fully automated-were compared. Performances were assessed by mixed-effects linear regression models. RESULTS: Agreement for skeletal and dental measurements was high, with minor differences observed between AI-driven and conventional registration approaches, and all methods showed clinically comparable precision. Most absolute average differences between automated and conventional workflows are under 1.5 mm for linear and 1.5 degrees for angular measurements. Cranial base superimposition differences showed an average difference in T2-T1 changes ranging from -0.3 to 0.7 mm, whereas regional superimposition differences showed an average difference in T2-T1 changes ranging from -1.7 to 1.1 mm. CONCLUSIONS: Automated clinician-verified workflow yields reliable and faster 3-dimensional change measures in growing patients. Interpretation must consider the reference region used for superimposition. AI-driven open-source tools provide a practical quantitative analysis to support diagnosis, timing, and assessment of treatment outcomes. CI - Copyright (c) 2026 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved. FAU - Huang, Yanjie AU - Huang Y AD - School of Dentistry, University of Michigan, Ann Arbor, Mich. FAU - Anchling, Luc AU - Anchling L AD - Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, Mich. FAU - Bates, William Ray AU - Bates WR AD - Department of Orthodontics, College of Dentistry, University of Tennessee Health Science Center, Memphis, Tenn. FAU - Gillot, Maxime AU - Gillot M AD - Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, Mich. FAU - Prieto, Juan Carlos AU - Prieto JC AD - Department of Psychiatry, University of North Carolina School of Medicine, Chapel Hill, NC. FAU - Nguyen, Tung AU - Nguyen T AD - Department of Orthodontics, Adam School of Dentistry, University of North Carolina, Chapel Hill, NC. FAU - Barone, Selene AU - Barone S AD - School of Dentistry, Department of Health Sciences, Magna Graecia University of Catanzaro, Viale Europa, Catanzaro, Italy. FAU - Miranda, Felicia AU - Miranda F AD - Bauru Dental School and Hospital for Rehabilitation of Craniofacial Anomalies, University of Sao Paulo, Bauru, Sao Paulo, Brazil. FAU - Gurgel, Marcela AU - Gurgel M AD - Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, Mich. FAU - Yatabe, Marilia AU - Yatabe M AD - Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, Mich. FAU - Evangelista, Karine AU - Evangelista K AD - Division of Orthodontics, Dental School, Federal University of Goias, Goias, Brazil. FAU - Larson, Brent E AU - Larson BE AD - Division of Orthodontics, Department of Developmental and Surgical Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minn. FAU - Bianchi, Jonas AU - Bianchi J AD - Department of Orthodontics, Arthur A. Dugoni School of Dentistry, University of the Pacific, San Francisco, Calif. FAU - De Oliveira Ruellas, Antonio Carlos AU - De Oliveira Ruellas AC AD - Department of Orthodontics, School of Dentistry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Cevidanes, Lucia AU - Cevidanes L AD - Department of Orthodontics and Pediatric Dentistry, School of Dentistry, University of Michigan, Ann Arbor, Mich. Electronic address: luciacev@umich.edu. LA - eng GR - R01 DE024450/DE/NIDCR NIH HHS/United States PT - Journal Article PT - Multicenter Study DEP - 20260220 PL - United States TA - Am J Orthod Dentofacial Orthop JT - American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics JID - 8610224 SB - IM MH - Humans MH - *Artificial Intelligence MH - *Imaging, Three-Dimensional/methods MH - *Cone-Beam Computed Tomography MH - Female MH - Male MH - Reproducibility of Results MH - Treatment Outcome MH - *Malocclusion, Angle Class II/diagnostic imaging/therapy MH - Adolescent MH - Child MH - Cephalometry/methods MH - Intelligent Systems PMC - PMC12925080 MID - NIHMS2145518 EDAT- 2026/02/21 12:29 MHDA- 2026/05/27 00:30 PMCR- 2026/06/10 CRDT- 2026/02/21 10:31 PHST- 2025/04/01 00:00 [received] PHST- 2025/12/01 00:00 [revised] PHST- 2025/12/01 00:00 [accepted] PHST- 2026/05/27 00:30 [medline] PHST- 2026/02/21 12:29 [pubmed] PHST- 2026/02/21 10:31 [entrez] PHST- 2026/06/10 00:00 [pmc-release] AID - S0889-5406(26)00033-8 [pii] AID - 10.1016/j.ajodo.2025.12.013 [doi] PST - ppublish SO - Am J Orthod Dentofacial Orthop. 2026 Jun;169(6):753-765. doi: 10.1016/j.ajodo.2025.12.013. Epub 2026 Feb 20. PMID- 41721453 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Feb 20 TI - The relationship between problematic digital media use and food addiction, eating behaviours, and obesity: a cross-sectional study on Turkish university students. LID - 10.1186/s40359-026-04168-3 [doi] LID - 420 AB - BACKGROUND: Problematic use of social media and smartphones has been increasingly linked to unhealthy lifestyle behaviors and weight-related problems. However, limited evidence exists on how these digital behaviors are associated with food addiction and obesity in young adults. AIMS: The aim of this study is to investigate the relationship between problematic digital media use and food addiction, eating behaviours, and obesity among Turkish university students. METHOD: A cross-sectional study was conducted between December 2024 and March 2025 with 331 students. Participants completed validated instruments, including the Social Media Addiction Scale-Adult Form, the Smartphone Addiction Scale-Short Form, the Modified Yale Food Addiction Scale 2.0, and the Eating Disorder Examination Questionnaire-Short Form (EDE-Q13). Anthropometric measurements were used to calculate body mass index (BMI). RESULTS: The mean age of the participants was 20.49 +/- 3.88 years, and 81% were female. Problematic smartphone use was significantly higher among students with moderate food addiction compared to those without food addiction (p < 0.001). Severe food addic-tion was associated with higher prevalence of eating disorders (p < 0.001) and higher BMI values (p < 0.001). Weak but significant correlations were found between problematic so-cial media use and binge eating (r = 0.133, p = 0.015) as well as purging behaviors (r = 0.190, p = 0.001). Similar associations emerged between problematic smartphone use and binge eating (r = 0.136, p = 0.013). CONCLUSIONS: Findings indicate that problematic social media and smartphone use are associated with food addiction, eating disorders, and higher BMI among young adults. Nevertheless, these results highlight the need for preventive strategies addressing digital media use in the context of eating behaviors and obesity risk. CI - (c) 2026. The Author(s). FAU - Toguc, Hakan AU - Toguc H AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Inonu University, Malatya, Turkey. hakan.toguc@inonu.edu.tr. LA - eng PT - Journal Article DEP - 20260220 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Turkey/epidemiology MH - *Food Addiction/epidemiology MH - *Obesity/epidemiology MH - Male MH - Young Adult MH - Universities MH - *Students/statistics & numerical data/psychology MH - *Social Media/statistics & numerical data MH - *Feeding Behavior/psychology MH - *Internet Addiction Disorder/epidemiology MH - Adult MH - *Smartphone/statistics & numerical data MH - Digital Media MH - Adolescent MH - Body Mass Index MH - Media Exposure MH - Behavior, Addictive PMC - PMC13032488 OTO - NOTNLM OT - Eating disorders OT - Food addiction OT - Obesity OT - Problematic smartphone use OT - Problematic social media use COIS- Declarations. Ethics approval and consent to participate: The study received ethical approval from Inonu University Health Sciences Non-Interventional Ethics Committee in accordance with the Declaration of Helsinki (Ref. No. 2024/6586). The informed consent form was read to the participants and they were included in the study after their consent was obtained. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/21 00:39 MHDA- 2026/03/28 06:39 PMCR- 2026/02/20 CRDT- 2026/02/20 23:59 PHST- 2025/09/03 00:00 [received] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/03/28 06:39 [medline] PHST- 2026/02/21 00:39 [pubmed] PHST- 2026/02/20 23:59 [entrez] PHST- 2026/02/20 00:00 [pmc-release] AID - 10.1186/s40359-026-04168-3 [pii] AID - 4168 [pii] AID - 10.1186/s40359-026-04168-3 [doi] PST - epublish SO - BMC Psychol. 2026 Feb 20;14(1):420. doi: 10.1186/s40359-026-04168-3. PMID- 41721441 OWN - NLM STAT- Publisher LR - 20260220 IS - 2047-783X (Electronic) IS - 0949-2321 (Linking) DP - 2026 Feb 20 TI - The association between serum copper levels and hyperuricemia in adolescents: an observational study. LID - 10.1186/s40001-026-04078-5 [doi] AB - OBJECTIVE: Hyperuricemia has been strongly associated with the risk of gout and metabolic syndrome. Serum copper may play a significant role in uric acid metabolism and the development of hyperuricemia. However, high-quality studies investigating the association between serum copper levels and the prevalence of hyperuricemia in adolescent populations remain scarce. This study aimed to evaluate the association between serum copper levels and the prevalence of hyperuricemia in a nationally representative sample of adolescents. METHODS: Data were obtained from the National Health and Nutrition Examination Survey conducted between 2011 and 2016, including a nationally representative sample of 1,034 adolescents aged 12 to 19 years. Serum copper concentrations and serum uric acid levels were measured through standardized laboratory procedures. Hyperuricemia was defined using sex-specific serum uric acid thresholds according to pubertal stage. The association between serum copper levels and the prevalence of hyperuricemia was assessed using multivariable logistic regression models, interaction analyses, and smoothed curve fitting to explore potential nonlinear relationships. RESULTS: Among the study population, 139 participants (13.44%) were identified with hyperuricemia. Except for the unadjusted model, a significant positive association was observed between serum copper levels and the prevalence of hyperuricemia. After controlling for all relevant confounders, each 1-unit increase in serum copper concentration was associated with a 5% higher prevalence of hyperuricemia (OR: 1.05, 95% CI: 1.00-1.10). This association remained consistent and statistically significant across various demographic and health-related subgroups. CONCLUSIONS: This study identified a positive association between serum copper levels and the prevalence of hyperuricemia in adolescents, suggesting that elevated serum copper may serve as a potential risk factor. These findings underscore the importance of monitoring serum copper levels as part of hyperuricemia prevention and management strategies in youth. Nonetheless, longitudinal studies are warranted to validate these associations and explore the underlying mechanisms. CI - (c) 2026. The Author(s). FAU - Wu, Yi AU - Wu Y AD - Nanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, 210003, People's Republic of China. FAU - Lv, Pin AU - Lv P AD - Department of Clinical Laboratory, Affiliated Nanjing Brain Hospital, Nanjing Medical University, Nanjing, 210003, People's Republic of China. 19941775535@163.com. LA - eng PT - Journal Article DEP - 20260220 PL - England TA - Eur J Med Res JT - European journal of medical research JID - 9517857 SB - IM OTO - NOTNLM OT - Adolescents OT - Hyperuricemia OT - NHANES OT - Serum copper OT - Uric acid metabolism COIS- Declarations. Ethics approval and consent to participate: All NHANES study protocols were approved by the Ethics Review Board of the National Center for Health Statistics. Written informed consent was obtained from all participants or from the parents/legal guardians of participants under the age of 16. These details are publicly accessible on the NHANES website (www.cdc.gov/nchs/nhanes/about/erb.html?CDC_AAref_Val=https://www.cdc.gov/nchs/nhanes/irba98.htm). Competing interests: The authors declare no competing interests. EDAT- 2026/02/21 00:40 MHDA- 2026/02/21 00:40 CRDT- 2026/02/20 23:59 PHST- 2025/07/22 00:00 [received] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/02/21 00:40 [medline] PHST- 2026/02/21 00:40 [pubmed] PHST- 2026/02/20 23:59 [entrez] AID - 10.1186/s40001-026-04078-5 [pii] AID - 10.1186/s40001-026-04078-5 [doi] PST - aheadofprint SO - Eur J Med Res. 2026 Feb 20. doi: 10.1186/s40001-026-04078-5. PMID- 41721323 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2026 Feb 21 TI - Development and validation of a nomogram for assessing the risk of periodontitis in youth: a cross-sectional study. LID - 10.1186/s12903-026-07889-4 [doi] LID - 538 AB - BACKGROUND: Periodontitis is becoming increasingly common in youth. However, a validated model for assessing the risk of periodontitis in youth is lacking. This study aimed to identify independent risk factors and develop a nomogram for assessing periodontitis risk in youth within a clinical setting. METHODS: In this cross-sectional study, we recruited 807 participants aged 10-24 from the Periodontology Department of Qingdao Stomatological Hospital (Qingdao, Shandong, China). Data on 16 potential risk factors were collected. The participants were randomly allocated to the training and validation cohorts in a 7:3 ratio. Independent factors were identified via univariate and multivariate logistic regression analysis, which were then used to develop a nomogram for assessing the risk of periodontitis in youth within this clinical setting. The model's validation and performance were rigorously evaluated using the area under the curve (AUC), sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), calibration plots, and decision curve analysis (DCA). RESULTS: Multivariate logistic regression analysis identified age, mouth breathing, impacted teeth, family history, and higher body mass index (BMI) as significant risk factors of periodontitis, while flossing was a protective factor. Accordingly, a nomogram was developed based on these factors as a risk assessing tool for youth in a clinical setting. Both the training and validation cohorts confirmed the nomogram's strong assessment performance, evidenced by AUC of 0.837 and 0.783, respectively. The model also maintained high sensitivity (91.2% and 86.5%) and NPV (91.5% and 90.8%) across both cohorts. Good calibration was achieved, with Brier scores of 0.162 (95% CI: 0.145-0.179) for the training cohort and 0.177 (95% CI: 0.148-0.207) for the validation cohort. Furthermore, the model's clinical utility was underscored by the DCA. CONCLUSIONS: We successfully developed and validated the nomogram for assessing the risk of periodontitis in youth within a clinical setting. With its high AUC, this model shows significant potential to support clinical decision-making by identifying high-risk individuals, thereby facilitating targeted evaluation and optimized management in specialist practice. FAU - Zhang, Ping AU - Zhang P AD - Department of Periodontology, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, China. FAU - Sun, Degang AU - Sun D AD - Department of Cariology and Endodontology, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, China. FAU - Wu, Han AU - Wu H AD - Department of Dean's Office, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, China. FAU - Wang, Hongyu AU - Wang H AD - Department of Periodontology, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, China. FAU - Pan, Jie AU - Pan J AD - Department of Periodontology, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, China. FAU - Wu, Yingtao AU - Wu Y AD - Department of Periodontology, Qingdao Stomatological Hospital Affiliated to Qingdao University, Qingdao, Shandong, China. 347107303@qq.com. LA - eng GR - 2023-WJZD153/Medical and Health Scientific Research Project of Qingdao/ GR - 2023-WJZD150/Medical and Health Scientific Research Project of Qingdao/ GR - 2025-2027/Qingdao Key Medical and Health Discipline Project/ GR - 2025-2027/Shandong Provincial Key Medical and Health Discipline of Oral Medicine (Qingdao University Affiliated Qingdao Stomatological Hospital)/ PT - Journal Article PT - Validation Study DEP - 20260221 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Nomograms MH - Cross-Sectional Studies MH - Adolescent MH - Female MH - Risk Factors MH - *Periodontitis/epidemiology/etiology MH - Child MH - Male MH - Young Adult MH - Risk Assessment/methods MH - China/epidemiology PMC - PMC13032324 OTO - NOTNLM OT - Nomogram OT - Periodontitis OT - Risk factors OT - Youth COIS- Declarations. Ethics approval and consent to participate: The study was conducted in compliance with the principles of the Declaration of Helsinki. Ethical approval was granted by the Ethics Committee at Qingdao Stomatological Hospital Affiliated to Qingdao University (2024KQYX025). Written informed consent was obtained from all participants. For participants who were under the age of 16, consent was provided by their parent or legal guardian. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/21 00:39 MHDA- 2026/06/27 06:44 PMCR- 2026/02/21 CRDT- 2026/02/20 23:50 PHST- 2025/10/03 00:00 [received] PHST- 2026/02/05 00:00 [accepted] PHST- 2026/06/27 06:44 [medline] PHST- 2026/02/21 00:39 [pubmed] PHST- 2026/02/20 23:50 [entrez] PHST- 2026/02/21 00:00 [pmc-release] AID - 10.1186/s12903-026-07889-4 [pii] AID - 7889 [pii] AID - 10.1186/s12903-026-07889-4 [doi] PST - epublish SO - BMC Oral Health. 2026 Feb 21;26(1):538. doi: 10.1186/s12903-026-07889-4. PMID- 41720915 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20261025 IS - 1476-5497 (Electronic) IS - 0307-0565 (Print) IS - 0307-0565 (Linking) VI - 50 IP - 4 DP - 2026 Apr TI - Genetic determinants of BMI, diet, and fitness interact to partially explain anthropometric obesity traits but not the metabolic consequences of obesity in men and women. PG - 938-946 LID - 10.1038/s41366-026-02027-0 [doi] AB - BACKGROUND: Understanding how genetic factors interact with diet and lifestyle to influence obesity is critical as we move towards models of precision nutrition and medicine. OBJECTIVES: To assess how genetic and lifestyle factors influence the variation in body composition and metabolic syndrome (Metsyn) risk factors. METHODS: A cross-sectional sample of age/sex/BMI-balanced 18-66 year old men and women (n = 211) from the USDA Nutritional Phenotyping Study were included in the analysis (NCT02367287). BMI polygenic risk scores (PRS) were calculated with the pgs_calc pipeline. Associations with body composition and Metsyn traits were assessed by linear regression and ANCOVA. Explained variance was evaluated using sum of squares and partial R(2), with model constraint using Bayesian information criteria. RESULTS: The PRS independently explained 15.6% of BMI variance and, after adjusting for age, sex, and genetic population structure, accounted for 11.3% of BMI variance (p(ANCOVA) = 1.1 x 10(-)(7)). Measures of diet quality, fitness, and resting metabolic rate (RMR) showed mixed independent associations with obesity traits. In best fit models, while the PRS was significant for DXA outcomes, waist circumference, and fasting TG, the explained variance was below 3% except in android-to-gynoid ratio (3.3%), lean mass index (6.6%), and waist circumference (10.1%). The BMI PRS showed subtle associations with the metabolic/physiological consequences of obesity, only waist circumference and plasma glucose were associated with PRS. Blood pressure, triglycerides, and HDL levels were not associated with PRS for obesity. CONCLUSIONS: The genetic factors influencing BMI appear to differ from those contributing to measures of adiposity and metabolic consequences of obesity. Genetic risk of high BMI was validated in this cohort, but sex, RMR, and fitness are the more refined determinants of adiposity and dysregulated metabolism in this healthy population. Future research should be sure to utilize genetic risk predictors specifically associated with maladaptive obesity traits rather than more broad associated phenotypes. CLINICAL TRIAL REGISTRY: NCT02367287. CI - (c) 2026. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. FAU - Arrington, Carmen E AU - Arrington CE AUID- ORCID: 0000-0001-7403-5976 AD - Department of Nutrition, University of California-Davis, Davis, CA, USA. FAU - Tacad, Debra K M AU - Tacad DKM AUID- ORCID: 0000-0002-7383-1564 AD - West Coast Metabolomics Center, University of California-Davis, Davis, CA, USA. FAU - Allayee, Hooman AU - Allayee H AD - Department of Medicine, David Geffen School of Medicine of UCLA, Los Angeles, CA, USA. FAU - Sutton, Kristen J AU - Sutton KJ AUID- ORCID: 0000-0002-3704-3560 AD - Department of Biomedical Informatics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA. FAU - Dombroski, Catherine AU - Dombroski C AD - Department of Neurobiology, Physiology and Behavior, University of California-Davis, Davis, CA, USA. AD - School of Veterinary Medicine, University of California-Davis, Davis, CA, USA. FAU - Keim, Nancy L AU - Keim NL AD - Department of Nutrition, University of California-Davis, Davis, CA, USA. AD - USDA-ARS Western Human Nutrition Research Center, Davis, CA, USA. FAU - Newman, John W AU - Newman JW AUID- ORCID: 0000-0001-9632-6571 AD - West Coast Metabolomics Center, University of California-Davis, Davis, CA, USA. AD - USDA-ARS Western Human Nutrition Research Center, Davis, CA, USA. FAU - Bennett, Brian J AU - Bennett BJ AUID- ORCID: 0000-0002-0766-3195 AD - Department of Nutrition, University of California-Davis, Davis, CA, USA. brian.bennett@usda.gov. AD - USDA-ARS Western Human Nutrition Research Center, Davis, CA, USA. brian.bennett@usda.gov. LA - eng SI - ClinicalTrials.gov/NCT02367287 SI - ClinicalTrials.gov/NCT02367287 GR - T32 DK007658/DK/NIDDK NIH HHS/United States GR - 2032-10700-003-000-D/USDA project/ GR - 2032-51530-025-00D/USDA project/ PT - Journal Article DEP - 20260220 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM MH - Humans MH - *Body Mass Index MH - Male MH - *Obesity/genetics/epidemiology/physiopathology/metabolism MH - Female MH - Adult MH - Middle Aged MH - Cross-Sectional Studies MH - Adolescent MH - Metabolic Syndrome/genetics/epidemiology MH - *Diet/statistics & numerical data MH - Aged MH - *Physical Fitness/physiology MH - Body Composition/genetics MH - Young Adult MH - Genetic Risk Score MH - Genetic Predisposition to Disease PMC - PMC13056523 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/02/21 00:40 MHDA- 2026/04/08 00:30 PMCR- 2026/02/20 CRDT- 2026/02/20 23:25 PHST- 2025/06/24 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2025/12/15 00:00 [revised] PHST- 2026/04/08 00:30 [medline] PHST- 2026/02/21 00:40 [pubmed] PHST- 2026/02/20 23:25 [entrez] PHST- 2026/02/20 00:00 [pmc-release] AID - 10.1038/s41366-026-02027-0 [pii] AID - 2027 [pii] AID - 10.1038/s41366-026-02027-0 [doi] PST - ppublish SO - Int J Obes (Lond). 2026 Apr;50(4):938-946. doi: 10.1038/s41366-026-02027-0. Epub 2026 Feb 20. PMID- 41719755 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 2213-1582 (Electronic) IS - 2213-1582 (Linking) VI - 49 DP - 2026 TI - Longitudinal MRI-based changes in intracranial volume and skull thickness observed in both metachromatic leukodystrophy and multiple sclerosis. PG - 103968 LID - S2213-1582(26)00027-6 [pii] LID - 10.1016/j.nicl.2026.103968 [doi] LID - 103968 AB - Intracranial volume (ICV) is often used as normalization factor in volumetrics and considered to be stable in young adults. We noticed thick skulls on MRI scans of leukodystrophy patients, suggesting potentially changing skull morphology. In this study we aimed to quantify skull thickness and ICV in metachromatic leukodystrophy (MLD) patients and people with multiple sclerosis (pwMS). We retrospectively analyzed single-center cross-sectional and longitudinal MRI scans. Skull thickness and ICV were determined using automated segmentation techniques. Participants included MLD (n = 32, 11 male, scans = 136, median age first scan = 14.1 [IQR 7.9-25.7] years), MS (n = 232, 78 male, median age first scan = 47.3 [IQR 39.6-55.4] years, scans = 431), and controls (n = 139, 67 male, median age first scan = 30.7 [IQR 10.7-48.9] years, scans = 283). Both ICV and skull thickness showed natural growth in young controls. In young MLD participants, ICV decreased (-18.8 +/- 22.4 mL/year, p < 0.001). Above age 20, ICV and skull thickness remained stable in controls. In comparison to controls, we observed ICV loss in MLD participants (-4.01 +/- 8.29 mL/year, p < 0.001) and in pwMS (-2.99 +/- 2.69 mL/year, p < 0.001), as well as skull thickening (MLD: 0.16 +/- 0.14 mm/year, p < 0.001, pwMS: 0.04 +/- 0.09 mm/year, p = 0.009). In adult patient groups, negative correlations were found between ICV and skull thickness (MLD: -19.24 mL/mm, p < 0.001, pwMS: -11.56 mL/mm, p < 0.001), but not in controls (p = 0.11). Despite limitations due to scanner variations, segmentation reliability and absence of validation against ground truth, these findings demonstrate a reduction in ICV in pathologies, already in young adulthood. Although the observed changes are small, they may lead to underestimations of atrophy when using ICV as a normalization factor. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Vorst, Guus H J AU - Vorst GHJ AD - Amsterdam Leukodystrophy Centre, Department of Child Neurology, Emma Children's Hospital, and Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam 1105 AZ, the Netherlands. FAU - Wolf, Nicole I AU - Wolf NI AD - Amsterdam Leukodystrophy Centre, Department of Child Neurology, Emma Children's Hospital, and Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam 1105 AZ, the Netherlands. FAU - van Nederpelt, David R AU - van Nederpelt DR AD - MS Center Amsterdam, Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam 1081 HV, the Netherlands. FAU - Barkhof, Frederik AU - Barkhof F AD - MS Center Amsterdam, Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam 1081 HV, the Netherlands; UCL Queen Square Institute of Neurology and Centre for Medical Image Computing, University College London, London WC1N 3BG, United Kingdom. FAU - van der Knaap, Marjo S AU - van der Knaap MS AD - Amsterdam Leukodystrophy Centre, Department of Child Neurology, Emma Children's Hospital, and Amsterdam Neuroscience, Amsterdam University Medical Center, Vrije Universiteit, Amsterdam 1105 AZ, the Netherlands. FAU - Schoonheim, Menno M AU - Schoonheim MM AD - MS Center Amsterdam, Department of Anatomy & Neurosciences, Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam 1081 HV, the Netherlands. FAU - Strijbis, Eva M M AU - Strijbis EMM AD - MS Center Amsterdam, Department of Neurology, Amsterdam University Medical Center, Amsterdam 1081 HV, the Netherlands. FAU - Pouwels, Petra J W AU - Pouwels PJW AD - MS Center Amsterdam, Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Amsterdam University Medical Center, Amsterdam 1081 HV, the Netherlands. Electronic address: pjw.pouwels@amsterdamumc.nl. LA - eng PT - Journal Article DEP - 20260216 PL - Netherlands TA - Neuroimage Clin JT - NeuroImage. Clinical JID - 101597070 SB - IM MH - Humans MH - Male MH - Adult MH - *Magnetic Resonance Imaging/methods MH - *Skull/diagnostic imaging/pathology MH - Female MH - Longitudinal Studies MH - Retrospective Studies MH - *Multiple Sclerosis/diagnostic imaging/pathology MH - Young Adult MH - Middle Aged MH - *Leukodystrophy, Metachromatic/diagnostic imaging/pathology MH - Adolescent MH - Child MH - Cross-Sectional Studies MH - Organ Size MH - *Brain/diagnostic imaging/pathology PMC - PMC12934227 OTO - NOTNLM OT - Intracranial volume OT - Metachromatic leukodystrophy OT - Multiple sclerosis OT - Neurodegeneration OT - Skull COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: The authors of this manuscript declare relationships with the following companies: N.I. Wolf is the initiator of the deferiprone trial for Pelizaeus-Merzbacher disease and advisor and/or local PI for premarketing clinical trials in Metachromatic Leukodystrophy and other leukodystrophies (Shire/Takeda, Ionis, PassageBio, VigilNeuro, Sana Biotech, Lilly, Calico), consulting fees are paid to the institution. She is member of the MLD initiative and the European Reference Network "Rare Neurological Diseases" (ERN-RND), project ID 739510. D.R. van Nederpelt is supported by the European Union's Horizon Widera programme under grant agreement no. 101159624 (TACTIX). F. Barkhof is part of the Steering committee or Data Safety Monitoring Board member for Biogen, Merck, Eisai and Prothena. Advisory board member for Combinostics, Scottish Brain Sciences, Alzheimer Europe. Consultant for Roche, Celltrion, Rewind Therapeutics, Merck, Bracco. Research agreements with ADDI, Merck, Biogen, GE Healthcare, Roche. Co-founder and shareholder of Queen Square Analytics LTD. M.M. Schoonheim serves on the editorial board of Neurology, Multiple Sclerosis Journal and Frontiers in Neurology, receives research support from the Dutch MS Research Foundation, Eurostars-EUREKA, ARSEP, Amsterdam Neuroscience and ZonMW (Vidi grant, project number 09150172010056) and has served as a consultant for or received research support from Atara Biotherapeutics, Biogen, Celgene/Bristol Meyers Squibb, EIP, Sanofi, MedDay and Merck. E.M.M. Strijbis serves on the editorial board of Neurology and Frontiers in Neurology and has received speaker fees from Merck and Novartis. Given their role as editorial board members, M.M. Schoonheim and E.M.M Strijbis had no involvement in the peer review of this article and had no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to another journal editor All other authors report no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/02/21 00:56 MHDA- 2026/03/16 00:29 PMCR- 2026/02/16 CRDT- 2026/02/20 18:04 PHST- 2025/11/24 00:00 [received] PHST- 2026/02/03 00:00 [revised] PHST- 2026/02/14 00:00 [accepted] PHST- 2026/03/16 00:29 [medline] PHST- 2026/02/21 00:56 [pubmed] PHST- 2026/02/20 18:04 [entrez] PHST- 2026/02/16 00:00 [pmc-release] AID - S2213-1582(26)00027-6 [pii] AID - 103968 [pii] AID - 10.1016/j.nicl.2026.103968 [doi] PST - ppublish SO - Neuroimage Clin. 2026;49:103968. doi: 10.1016/j.nicl.2026.103968. Epub 2026 Feb 16. PMID- 41719635 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260708 IS - 1532-3099 (Electronic) IS - 0266-6138 (Linking) VI - 156 DP - 2026 May TI - A comparative analysis of three psychological challenge assessment tools for predicting breastfeeding outcome at six months postpartum. PG - 104743 LID - S0266-6138(26)00047-1 [pii] LID - 10.1016/j.midw.2026.104743 [doi] AB - PROBLEM: Psychological challenges experienced by mothers are strongly associated with breastfeeding cessation within six months after childbirth. BACKGROUND: The Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF), Maternal Breastfeeding Evaluation Scale (MBFES), and Existential Breastfeeding Scale (ExBreastS) assess distinct psychological aspects of breastfeeding challenges. Their predictive value for 6-month outcomes in Chinese mothers is underexplored. AIM: To evaluate and compare the predictive performance of the BSES-SF, MBFES, and ExBreastS for breastfeeding outcomes at six months postpartum. METHODS: From June to September 2024, postpartum mothers ( A; R > Q) and mandibular skeletal malocclusion in the Mazandaran people of Northern Iran. METHODS: At the Arash Orthodontic Clinic in Babol, Iran, 393 individuals (148 controls, 119 with mandibular prognathism, and 126 with mandibular retrognathism) were screened for this case-control study. Cephalometric analysis, using Steiner parameters and "Wits" appraisal, verified skeletal relationships. Genomic DNA, extracted from gingival blood samples, was genotyped for rs1383180 using polymerase chain reaction-restriction fragment length polymorphism and validated using Sanger sequencing. Bioinformatics tools, including MUpro, iStable, DynaMut2, INPS-MD, SWISS-MODEL, ConSurf, PhD-SNPg, and Cscape, predicted the impact of the variant on protein function. RESULTS: The AA genotype of rs1383180 was significantly associated with mandibular prognathism (p = 0.036) and the mutant allele (A) trended towards significance (p = 0.081). There was no association with mandibular retrognathism. Bioinformatics analysis predicted that the G > A transition may disrupt the structure and stability of EVC protein. ConSurf indicated moderate evolutionary conservation and PhD-SNPg and Cscape identified rs1383180 as pathogenic and oncogenic. CONCLUSION: The AA genotype of rs1383180 was associated with an increased risk of skeletal Class III malocclusion due to mandibular prognathism. As this genotype may disrupt Hedgehog signaling, this pathway may be influencing mandibular development. CI - Copyright (c) 2025 Japanese Association for Oral Biology. Published by Elsevier B.V. All rights reserved. FAU - Gholampour, Nikta AU - Gholampour N AD - Department of Molecular and Cell Biology, Faculty of Basic Science, University of Mazandaran, PC:47416-95447, Babolsar, Mazandaran, Iran. Electronic address: gholampour.nikta@gmail.com. FAU - Kalmari, Amin AU - Kalmari A AD - Department of Molecular and Cell Biology, Faculty of Basic Science, University of Mazandaran, PC:47416-95447, Babolsar, Mazandaran, Iran. Electronic address: a.kalmari@yahoo.com. FAU - Colagar, Abasalt Hosseinzadeh AU - Colagar AH AD - Department of Molecular and Cell Biology, Faculty of Basic Science, University of Mazandaran, PC:47416-95447, Babolsar, Mazandaran, Iran. Electronic address: acolagar@yahoo.com. FAU - Arash, Valiollah AU - Arash V AD - Department of Orthodontics, School of Dentistry, Babol University of Medical Sciences, PC: 47176-47745, Babol, Mazandaran, Iran. Electronic address: v.arash@mubabol.ac.ir. LA - eng PT - Journal Article DEP - 20251121 PL - Netherlands TA - J Oral Biosci JT - Journal of oral biosciences JID - 101226721 SB - IM MH - Humans MH - *Polymorphism, Single Nucleotide MH - *Mandible/growth & development MH - Female MH - Male MH - Case-Control Studies MH - Genotype MH - Prognathism/genetics MH - Iran MH - *Malocclusion/genetics MH - *Morphogenesis/genetics MH - Adolescent MH - Retrognathia/genetics MH - Cephalometry MH - Computational Biology MH - Polymerase Chain Reaction OTO - NOTNLM OT - EVC OT - Mandibular prognathism OT - Mandibular retrognathism OT - Single nucleotide polymorphism OT - rs1383180 COIS- Declaration of competing interest The authors declare that there are no conflicts of interest. EDAT- 2026/02/20 00:32 MHDA- 2026/02/20 00:33 CRDT- 2026/02/19 20:55 PHST- 2025/07/22 00:00 [received] PHST- 2025/11/08 00:00 [revised] PHST- 2025/11/13 00:00 [accepted] PHST- 2026/02/20 00:33 [medline] PHST- 2026/02/20 00:32 [pubmed] PHST- 2026/02/19 20:55 [entrez] AID - S1349-0079(25)00100-8 [pii] AID - 10.1016/j.job.2025.100711 [doi] PST - ppublish SO - J Oral Biosci. 2026 Feb;68(1):100711. doi: 10.1016/j.job.2025.100711. Epub 2025 Nov 21. PMID- 41713842 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260709 IS - 1541-6100 (Electronic) IS - 0022-3166 (Linking) VI - 156 IP - 5 DP - 2026 May TI - Association between Vitamin A and Anemia in Chinese Children: A Matched Case-Control Study. PG - 101423 LID - S0022-3166(26)00072-6 [pii] LID - 10.1016/j.tjnut.2026.101423 [doi] AB - BACKGROUND: Vitamin A plays an important role in the development of anemia, providing a new perspective on improving anemia. OBJECTIVES: This study aimed to investigate the dose-response relationship between serum vitamin A and anemia risk, and evaluate its clinical applicability with adjustment for covariates. METHODS: A 1:3 matched case-control study (202 cases, 606 controls) was conducted, matching for sex and age (+/-2 y). Assess matching balance using the standardized mean difference. Anemia was defined according to the World Health Organization criteria. Unconditional logistic regression was used to assess the effect of vitamin A after adjusting for confounders. Variable adjustment was informed by a directed acyclic graph, with the primary model adjusting for age, sex, body mass index (BMI), and serum zinc (Zn). A restricted cubic spline (RCS) was applied to analyze the dose-response relationship. Subgroup analysis and interaction tests were used to examine the association across sexes. Model discrimination was evaluated using the receiver operating characteristic curve and its area under the curve (AUC). Model calibration was evaluated using calibration plots, the Hosmer-Lemeshow test, and the Brier score. RESULTS: The case group exhibited significantly lower amounts of BMI, vitamin D, vitamin A, total cholesterol, Zn, and serum ferritin (all P < 0.05). After adjusting for age, sex, BMI, and Zn, each 0.1 mug/mL increase in serum vitamin A was associated with a 27% reduction in anemia risk [odds ratio (OR) = 0.73, 95% confidence interval (CI): 0.62, 0.87, P < 0.001]. RCS analysis confirmed a linear dose-response relationship (P for nonlinearity = 0.922). Sex-stratified analysis using unconditional logistic regression suggested a numerically stronger association in males (OR = 0.55, 95% CI: 0.38, 0.78, P < 0.001) than in females (OR = 0.82, 95% CI: 0.67, 1.00, P = 0.053); "sex x vitamin A" interaction was statistically significant (P = 0.019). The prediction model including vitamin A improved AUC to 0.63 (DeltaAUC = 0.11, P < 0.001) and demonstrated good calibration (Brier score = 0.180; Hosmer-Lemeshow P = 0.636). CONCLUSIONS: Serum vitamin A demonstrates a significant, independent, and linear inverse association with anemia risk in children and adolescents. This association was more pronounced in males, indicating a potential role for vitamin A in sex-specific anemia prevention strategies. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Sun, Yan AU - Sun Y AD - Institute of Public Health Surveillance and Evaluation, Guizhou Center for Disease Control and Prevention, Guiyang, China. FAU - Long, Hong-Jiang AU - Long HJ AD - Institute of Public Health Surveillance and Evaluation, Guizhou Center for Disease Control and Prevention, Guiyang, China. FAU - Guo, Hua AU - Guo H AD - Institute of Public Health Surveillance and Evaluation, Guizhou Center for Disease Control and Prevention, Guiyang, China. FAU - Liu, Yi-Ya AU - Liu YY AD - Institute of Public Health Surveillance and Evaluation, Guizhou Center for Disease Control and Prevention, Guiyang, China. Electronic address: liuliuliu202510@163.com. LA - eng PT - Journal Article PT - Observational Study DEP - 20260217 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 RN - 9007-73-2 (Ferritins) RN - 11103-57-4 (Vitamin A) RN - 1406-16-2 (Vitamin D) RN - J41CSQ7QDS (Zinc) SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - *Anemia/blood/epidemiology MH - Body Mass Index MH - Case-Control Studies MH - China/epidemiology MH - Ferritins/blood MH - Logistic Models MH - *Vitamin A/blood/administration & dosage MH - Vitamin A Deficiency/complications/blood MH - Vitamin D/blood MH - Zinc/blood OTO - NOTNLM OT - childhood anemia OT - matched design OT - restricted cubic splines OT - serum retinol OT - sex difference COIS- Conflict of interest The authors report no conflicts of interest. EDAT- 2026/02/20 00:32 MHDA- 2026/05/09 00:34 CRDT- 2026/02/19 19:32 PHST- 2025/11/06 00:00 [received] PHST- 2026/02/05 00:00 [revised] PHST- 2026/02/12 00:00 [accepted] PHST- 2026/05/09 00:34 [medline] PHST- 2026/02/20 00:32 [pubmed] PHST- 2026/02/19 19:32 [entrez] AID - S0022-3166(26)00072-6 [pii] AID - 10.1016/j.tjnut.2026.101423 [doi] PST - ppublish SO - J Nutr. 2026 May;156(5):101423. doi: 10.1016/j.tjnut.2026.101423. Epub 2026 Feb 17. PMID- 41713464 OWN - NLM STAT- In-Process LR - 20260302 IS - 1555-0273 (Electronic) IS - 1555-0265 (Linking) VI - 21 IP - 3 DP - 2026 Mar 1 TI - A Comment on "Evaluating the Reliability and Seasonal Sensitivity of a Fitness-Testing Battery in Elite Youth Soccer". PG - 339 LID - 10.1123/ijspp.2025-0600 [doi] FAU - Lolli, Lorenzo AU - Lolli L AUID- ORCID: 0000-0001-8670-3361 AD - Department of Sport and Exercise Sciences, Institute of Sport, Manchester Metropolitan University, Manchester, United Kingdom. LA - eng PT - Journal Article DEP - 20260216 PL - United States TA - Int J Sports Physiol Perform JT - International journal of sports physiology and performance JID - 101276430 SB - IM EDAT- 2026/02/20 00:32 MHDA- 2026/02/20 00:32 CRDT- 2026/02/19 18:53 PHST- 2025/11/10 00:00 [received] PHST- 2025/11/21 00:00 [accepted] PHST- 2026/02/20 00:32 [pubmed] PHST- 2026/02/20 00:32 [medline] PHST- 2026/02/19 18:53 [entrez] AID - 10.1123/ijspp.2025-0600 [doi] PST - epublish SO - Int J Sports Physiol Perform. 2026 Feb 16;21(3):339. doi: 10.1123/ijspp.2025-0600. Print 2026 Mar 1. PMID- 41713463 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260708 IS - 1543-5474 (Electronic) IS - 1543-3080 (Linking) VI - 23 IP - 6 DP - 2026 Jun 1 TI - Prevalence of Motor Competence in Chilean Schoolchildren and Its Association With Sex, Age, and Weight Status: The CoMoSur Study. PG - 862-870 LID - 10.1123/jpah.2025-0644 [doi] AB - BACKGROUND: Chile is one of the countries with the lowest indicators of children's physical activity therefore it is necessary to promote the development of factors that encourage regular practice, such as motor competence (MC), which is considered a fundamental factor in improving physical activity trajectories in school-age children. This CoMoSur study aimed to determine the prevalence of MC in fifth- and sixth-grade primary school children in central-southern Chile and analyze the association of MC with sex, age, and weight status. METHODS: The MC of 1513 schoolchildren (49.4% girls; mean = 11.12 y, SD = 0.92) from 7 regions of central-southern Chile was assessed using the MOBAK 5-6 test. Confirmatory factor analyses and structural equation models were applied to test 2 models: (1) the factorial validity of the 2 dimensions of MC (object control and self-movement) and (2) the associations of MC with sex, age, and weight status. RESULTS: Low levels of MC were observed, especially in girls. Model 1 showed adequate fit indices (chi2 = 64.912, df = 19, P 0.90, except for CoP path length (COV = 10.5%, ICC = 0.64). Correlations among outcomes were weak (r range: 0.036-0.373). While all physical capacities declined with age (p < 0.001), effect sizes varied: from the least to the most age-sensitive outcome (eta2 values), we found differences in handgrip strength (eta2 = 0.035), sit-and-reach (eta2 = 0.050), finger tapping (eta2 = 0.059), CoP path length (eta2 = 0.095), lower-limb power (eta2 = 0.148), and cardiorespiratory fitness (eta2 = 0.389). The average PCA component scores revealed large age-related differences (eta2 = 0.301). Our findings suggest that the developed platform is a valuable tool for assessing physical function, and all physical tests captured distinct aspects of physical capacities. This highlights the necessity of employing a comprehensive battery of tests to gain a holistic understanding of an individual's physical health and detect age-related decline effectively. CI - Copyright: (c) 2026 Boccia et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Boccia, Gennaro AU - Boccia G AUID- ORCID: 0000-0001-8706-4098 AD - Department of Clinical and Biological Sciences, University of Turin, Turin, Italy. AD - Neuromuscular Function Research Group, School of Exercise & Sport Sciences, University of Turin, Turin, Italy. FAU - Brustio, Paolo Riccardo AU - Brustio PR AD - Department of Clinical and Biological Sciences, University of Turin, Turin, Italy. AD - Neuromuscular Function Research Group, School of Exercise & Sport Sciences, University of Turin, Turin, Italy. FAU - Mulasso, Anna AU - Mulasso A AUID- ORCID: 0000-0002-9092-2994 AD - Neuromuscular Function Research Group, School of Exercise & Sport Sciences, University of Turin, Turin, Italy. AD - Department of Medical Sciences, University of Turin, Turin, Italy. FAU - Tufo, Francesco AU - Tufo F AD - Neuromuscular Function Research Group, School of Exercise & Sport Sciences, University of Turin, Turin, Italy. AD - Department of Medical Sciences, University of Turin, Turin, Italy. FAU - Rainoldi, Alberto AU - Rainoldi A AD - Neuromuscular Function Research Group, School of Exercise & Sport Sciences, University of Turin, Turin, Italy. AD - Department of Medical Sciences, University of Turin, Turin, Italy. LA - eng PT - Journal Article PT - Validation Study DEP - 20260219 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Reproducibility of Results MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged MH - Aged MH - Principal Component Analysis MH - *Aging/physiology MH - *Exercise Test/methods/standards MH - *Physical Fitness/physiology MH - Hand Strength/physiology PMC - PMC12919782 COIS- The authors have declared that no competing interests exist. EDAT- 2026/02/19 19:02 MHDA- 2026/02/19 19:03 PMCR- 2026/02/19 CRDT- 2026/02/19 13:33 PHST- 2025/08/07 00:00 [received] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/02/19 19:03 [medline] PHST- 2026/02/19 19:02 [pubmed] PHST- 2026/02/19 13:33 [entrez] PHST- 2026/02/19 00:00 [pmc-release] AID - PONE-D-25-42580 [pii] AID - 10.1371/journal.pone.0343122 [doi] PST - epublish SO - PLoS One. 2026 Feb 19;21(2):e0343122. doi: 10.1371/journal.pone.0343122. eCollection 2026. PMID- 41712558 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 2 DP - 2026 TI - Protocol for the 'exploration of mental well-being, health-related quality of life, and psychosocial outcomes in youths on dialysis in New Zealand: A cross-sectional methods study'. PG - e0340006 LID - 10.1371/journal.pone.0340006 [doi] LID - e0340006 AB - INTRODUCTION: It is well accepted that young individuals on dialysis have poor clinical outcomes, although it is increasing apparent that they have similarly poor patient-centred ones. We study these latter outcomes in the population of youths undergoing dialysis in Aotearoa New Zealand (AoNZ). This study aims to report their sociodemographic and clinical characteristics, and explore their mental well-being and health-related quality of life, and how these outcomes are influenced by factors such as self-efficacy, physical activity, mood, and social anxiety. METHODS: A cross-sectional survey will be conducted of youths aged 15-24 years on dialysis in AoNZ with eligible youths on dialysis across AoNZ, using validated psychometric instruments to assess daily activities, mental health, quality of life, social interactions, and self-efficacy. Open-ended questions within the survey will collect qualitative data. Clinical and demographic data will be established from clinical records and linked public health databases. ANALYSIS: Quantitative data will be analyzed using descriptive statistics and structural equation modeling to explore associations between psychometric constructs, mental well-being, and quality of life. Open-ended questions will be analysed using qualitative content analysis. ETHICS AND DISSEMINATION: Informed consent will be sought from all participants. The research will adhere to data protection guidelines, ensuring that participants' rights and confidentiality are protected. Results will be disseminated through academic publications, conferences, and summary reports provided to participants and stakeholders. CI - Copyright: (c) 2026 Jaganathan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Jaganathan, Kavitha AU - Jaganathan K AUID- ORCID: 0000-0003-1102-0915 AD - Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. FAU - Serlachius, Anna AU - Serlachius A AD - Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. FAU - Prestidge, Chanel AU - Prestidge C AD - Department of Paediatric Nephrology, Starship Children's Health, Te Whatu Ora Health New Zealand Te Toka Tumai Auckland, Auckland, New Zealand. FAU - Doss, Fredric S AU - Doss FS AUID- ORCID: 0000-0002-1571-6138 AD - Renal Physiology, Auckland City Hospital, Te Whatu Ora Health New Zealand Te Toka Tumai Auckland, Auckland, New Zealand. AD - Department of Science, Auckland University of Technology, Auckland, New Zealand. FAU - Marshall, Mark R AU - Marshall MR AUID- ORCID: 0000-0003-0499-4527 AD - Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. AD - Department of Medicine, Waitakere Hospital, Te Whatu Ora Health New Zealand Waitemata, Auckland, New Zealand. LA - eng PT - Journal Article DEP - 20260219 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Quality of Life MH - New Zealand MH - Cross-Sectional Studies MH - Adolescent MH - *Renal Dialysis/psychology MH - Male MH - *Mental Health MH - Female MH - Young Adult MH - Psychological Well-Being MH - Self Efficacy MH - Surveys and Questionnaires MH - Psychometrics PMC - PMC12919795 COIS- The authors have declared that no competing interests exist. EDAT- 2026/02/19 19:02 MHDA- 2026/02/19 19:03 PMCR- 2026/02/19 CRDT- 2026/02/19 13:33 PHST- 2025/10/28 00:00 [received] PHST- 2025/12/15 00:00 [accepted] PHST- 2026/02/19 19:03 [medline] PHST- 2026/02/19 19:02 [pubmed] PHST- 2026/02/19 13:33 [entrez] PHST- 2026/02/19 00:00 [pmc-release] AID - PONE-D-25-52324 [pii] AID - 10.1371/journal.pone.0340006 [doi] PST - epublish SO - PLoS One. 2026 Feb 19;21(2):e0340006. doi: 10.1371/journal.pone.0340006. eCollection 2026. PMID- 41712524 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 1476-542X (Electronic) IS - 0250-832X (Linking) VI - 55 IP - 5 DP - 2026 Jul 1 TI - Quantifying cross-site effect in AI-based dental age estimation: evidence from Brazilian panoramic radiographs. PG - 477-486 LID - 10.1093/dmfr/twag014 [doi] AB - OBJECTIVES: To quantify cross-regional generalization of dental age-estimation models, identify practical strategies to improve their performance, and report uncertainty in a transparent manner. METHODS: A total of 21 722 panoramic radiographs from 2 Brazilian regions were acquired using distinct equipment. A robust Inception-v4 model was evaluated under 4 scenarios: (1) training on Northeast data and testing on Southeast data; (2) fine-tuning using Southeast data only or both regions; (3) training from scratch on pooled data; (4) pooled training with augmentation. Model performance was assessed using mean absolute error (MAE), mean signed error (bias), R2, Bland-Altman analysis, and calibration metrics. RESULTS: A marked performance drop was observed when the model trained on Northeast data was applied to Southeast radiographs (MAE 4.97 years vs 3.10 years in-region), with negative bias and wider Bland-Altman limits at older ages. Training with pooled regions and modest fine-tuning improved accuracy and calibration across both cohorts (MAE 3.24-3.69; R2 0.93-0.95). Data augmentation yielded only small additional improvements and did not eliminate large residual errors. Heatmaps highlighted clinically relevant anatomical structures commonly used by dental experts for age estimation. CONCLUSIONS: Cross-site and domain shifts significantly impact the performance of AI models for dental age estimation. Multi-regional training combined with light model adaptation provides robust, well-calibrated, and interpretable results across regions, whereas data augmentation alone has limited effectiveness. This study offers a 2-region benchmark, code, and data-access protocols to support reproducible evaluation and guide clinical deployment. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the British Institute of Radiology and the International Association of Dentomaxillofacial Radiology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Oliveira, Willian AU - Oliveira W AD - Centro de Informatica, Universidade Federal de Pernambuco, Recife, Pernambuco 50740-560, Brazil. FAU - Oliveira, Matheus L AU - Oliveira ML AUID- ORCID: 0000-0002-8054-8759 AD - Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Piracicaba, Sao Paulo 13414-903, Brazil. FAU - Haiter Neto, Francisco AU - Haiter Neto F AUID- ORCID: 0000-0002-5610-8307 AD - Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Piracicaba, Sao Paulo 13414-903, Brazil. FAU - Albuquerque Santos, Mariana AU - Albuquerque Santos M AUID- ORCID: 0000-0001-5208-8583 AD - Departamento de Clinica e Odontologia Preventiva, Universidade Federal de Pernambuco, Recife, Pernambuco 50670-901, Brazil. FAU - Dos Anjos Pontual, Maria Luiza AU - Dos Anjos Pontual ML AUID- ORCID: 0000-0002-5900-8328 AD - Departamento de Clinica e Odontologia Preventiva, Universidade Federal de Pernambuco, Recife, Pernambuco 50670-901, Brazil. FAU - Beltrao, Ricardo V AU - Beltrao RV AD - Department of Clinical and Social Dentistry, Centro de Ciencias da Saude, Universidade Federal da Paraiba, Jardim Universitario, Joao Pessoa, Paraiba 58051-900, Brazil. FAU - Pontual, Andrea A AU - Pontual AA AUID- ORCID: 0000-0003-3596-446X AD - Departamento de Clinica e Odontologia Preventiva, Universidade Federal de Pernambuco, Recife, Pernambuco 50670-901, Brazil. FAU - Ramos-Perez, Flavia Maria M AU - Ramos-Perez FMM AUID- ORCID: 0000-0001-9948-0769 AD - Departamento de Clinica e Odontologia Preventiva, Universidade Federal de Pernambuco, Recife, Pernambuco 50670-901, Brazil. FAU - Freitas, Deborah Queiroz AU - Freitas DQ AUID- ORCID: 0000-0002-1425-5966 AD - Faculdade de Odontologia de Piracicaba, Universidade Estadual de Campinas, Piracicaba, Sao Paulo 13414-903, Brazil. FAU - Zanchettin, Cleber AU - Zanchettin C AUID- ORCID: 0000-0001-6421-9747 AD - Centro de Informatica, Universidade Federal de Pernambuco, Recife, Pernambuco 50740-560, Brazil. LA - eng GR - #2022/07468-7/FACEPE and FAPESP/ PT - Journal Article PL - England TA - Dentomaxillofac Radiol JT - Dento maxillo facial radiology JID - 7609576 SB - IM MH - Humans MH - *Radiography, Panoramic/methods MH - Brazil MH - *Age Determination by Teeth/methods MH - *Artificial Intelligence MH - Child OTO - NOTNLM OT - age estimation OT - deep neural network OT - forensic sciences OT - radiological methods EDAT- 2026/02/19 19:02 MHDA- 2026/07/01 18:33 CRDT- 2026/02/19 13:15 PHST- 2025/10/03 00:00 [received] PHST- 2026/01/07 00:00 [revised] PHST- 2026/02/06 00:00 [accepted] PHST- 2026/07/01 18:33 [medline] PHST- 2026/02/19 19:02 [pubmed] PHST- 2026/02/19 13:15 [entrez] AID - 8490635 [pii] AID - 10.1093/dmfr/twag014 [doi] PST - ppublish SO - Dentomaxillofac Radiol. 2026 Jul 1;55(5):477-486. doi: 10.1093/dmfr/twag014. PMID- 41712241 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260708 IS - 2299-8306 (Electronic) IS - 0423-104X (Linking) VI - 77 IP - 1 DP - 2026 TI - Assessment of serum concentrations of the "satiety hormone" - peptide YY concentration in body weight disorders in girls with anorexia nervosa and obesity. PG - 72-80 LID - 10.5603/ep.108016 [doi] AB - INTRODUCTION: Peptide YY (PYY), a key satiety hormone, exhibits altered serum concentrations in body weight disorders, although its role remains debated. Conflicting adult studies highlight the need to clarify PYY 1-36 dynamics in pediatric populations with anorexia nervosa (AN) and obesity (OB). MATERIAL AND METHODS: Fasting serum PYY 1-36 concentrations were analyzed in 199 girls: 58 with restrictive AN [median age 15.0 (interquartile range; IQR): 14.0-16.0 years], 52 with OB [14.3 (12.3-16.3) years], and 89 healthy controls (C) [16.5 (15.5-17.5) years]. Anthropometric and metabolic/hormonal parameters were assessed. Group differences were evaluated using the Kruskal-Wallis rank-sum test. Relationships between fasting serum peptide YY (PYY) 1-36 concentrations and demographic/clinical parameters were examined using Spearman rank correlation coefficients. RESULTS: AN patients had significantly higher PYY 1-36 levels [77.2 (71.1-82.4) pg/mL] compared to OB [36.0 (34.3-38.5) pg/mL] and C [49.7 (46.7-51.5) pg/mL; p < 0.001]. A strong inverse correlation between PYY and body mass index (BMI) was observed across all subjects (Rho = -0.8, p < 0.001). Receiver operating characteristic (ROC)-derived cut-offs differentiated AN (> 59.04 pg/mL; sensitivity 95%, specificity 100%) and OB (< 43.18 pg/mL; sensitivity 89%, specificity 90%) from C. CONCLUSIONS: 1. Our research underscores significant PYY concentration disparities among weight disorders. 2. Significant differences in PYY concentrations in girls with body weight disorders as compared to healthy girls with normal body weight may indicate a role of this peptide in the body's adaptation to maintain energy homeostasis in connection with the ongoing disease. FAU - Golab-Jeneral, Katarzyna AU - Golab-Jeneral K AUID- ORCID: 0000-0001-7686-441X AD - Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland. katarzyna-golab1@wp.pl. FAU - Blaska, Malgorzata AU - Blaska M AD - Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland. FAU - Ziora-Jakutowicz, Karolina AU - Ziora-Jakutowicz K AD - Department of Genetics, Institute of Psychiatry and Neurology, Warsaw, Poland. FAU - Swietochowska, Elzbieta AU - Swietochowska E AD - Department of Medical and Molecular Biology, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland. FAU - Zachurzok, Agnieszka AU - Zachurzok A AD - Department of Pediatrics, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland. FAU - Ziora, Katarzyna AU - Ziora K AD - Professor emeritus, Medical University of Silesia, Katowice, Poland. LA - eng PT - Journal Article DEP - 20260219 PL - Poland TA - Endokrynol Pol JT - Endokrynologia Polska JID - 0370674 RN - 106388-42-5 (Peptide YY) SB - IM MH - Humans MH - Female MH - *Peptide YY/blood MH - *Anorexia Nervosa/blood MH - Adolescent MH - Child MH - *Obesity/blood MH - Case-Control Studies OTO - NOTNLM OT - PYY OT - anorexia nervosa OT - appetite-regulating hormones OT - eating-related disorders OT - obesity OT - peptide YY EDAT- 2026/02/19 17:35 MHDA- 2026/03/17 14:25 CRDT- 2026/02/19 11:33 PHST- 2025/08/07 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2025/10/27 00:00 [revised] PHST- 2026/03/17 14:25 [medline] PHST- 2026/02/19 17:35 [pubmed] PHST- 2026/02/19 11:33 [entrez] AID - VM/OJS/J/108016 [pii] AID - 10.5603/ep.108016 [doi] PST - ppublish SO - Endokrynol Pol. 2026;77(1):72-80. doi: 10.5603/ep.108016. Epub 2026 Feb 19. PMID- 41711800 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 2177-6709 (Electronic) IS - 2176-9451 (Print) IS - 2176-9451 (Linking) VI - 30 IP - 6 DP - 2026 TI - Comparison of three instruments (compass, digital caliper and 3d software) for dental linear measurements on plaster and digitalized models of infants and children: an agreement and reproducibility study. PG - e2525164 LID - S2176-94512025000600305 [pii] LID - 10.1590/2177-6709.30.6.e2525164.oar [doi] LID - e2525164 AB - OBJECTIVE: The aim of the study was to evaluate the reproducibility and agreement of dental linear measurements made directly on plaster models with a compass, and a digital caliper, compared to digital measurements made through software on the same plaster models after digitalization. METHODS: 40 plaster models from 20 infants and children aged between 1 and 5 years old, of both sex, with complete or incomplete primary dentition, with or without premature loss of primary anterior teeth were selected. The models were scanned using the Optical 3D scanner. Two calibrated operators performed dental linear measurements with a compass and a digital caliper directly on the plaster models and with the Autodesk Meshmixer software on the digital models. Six measurements were evaluated: missing tooth space (if any), arch perimeter, arch length, arch width, intercanine length and intercanine width. Statistical analysis was performed through the Jamovi program. Inter-rater reproducibility was calculated using the intraclass correlation coefficient (ICC) and agreement between instruments was analyzed using the Bland-Altman test. RESULTS: Inter-rater ICC showed excellent consistency, ranging from 0.93 to 1.00. Agreement between instruments was good, with the mean difference ranging from 0.034 mm (limits: -1.077 to 1.145 mm) to -1.002 mm (limits: -0.831 to 0.185 mm). CONCLUSION: Dental linear measurements performed on digital models obtained from scanned plaster models demonstrated excellent reproducibility and good agreement compared to those made with a compass and a digital caliper. All measurement instruments can be reliably used in dental clinical practice. FAU - Nadelman, Patricia AU - Nadelman P AUID- ORCID: 0000-0001-5782-1203 AD - Federal University of Rio de Janeiro, Department of Pediatric Dentistry and Orthodontics, School of Dentistry (Rio de Janeiro/RJ, Brazil). FAU - Vargas, Eduardo Otero Amaral AU - Vargas EOA AUID- ORCID: 0000-0002-0902-6878 AD - Federal University of Rio de Janeiro, Department of Pediatric Dentistry and Orthodontics, School of Dentistry (Rio de Janeiro/RJ, Brazil). FAU - Amorim, Camila Silva de AU - Amorim CS AUID- ORCID: 0000-0002-8196-3495 AD - Federal University of Rio de Janeiro, Department of Pediatric Dentistry and Orthodontics, School of Dentistry (Rio de Janeiro/RJ, Brazil). FAU - Castro, Amanda Cunha Regal de AU - Castro ACR AUID- ORCID: 0000-0001-7174-3846 AD - Federal University of Rio de Janeiro, Department of Pediatric Dentistry and Orthodontics, School of Dentistry (Rio de Janeiro/RJ, Brazil). FAU - Pithon, Matheus Melo AU - Pithon MM AUID- ORCID: 0000-0002-8418-4139 AD - Federal University of Rio de Janeiro, Department of Pediatric Dentistry and Orthodontics, School of Dentistry (Rio de Janeiro/RJ, Brazil). FAU - Maia, Lucianne Cople AU - Maia LC AUID- ORCID: 0000-0003-1026-9401 AD - Federal University of Rio de Janeiro, Department of Pediatric Dentistry and Orthodontics, School of Dentistry (Rio de Janeiro/RJ, Brazil). LA - eng PT - Comparative Study PT - Journal Article DEP - 20260213 PL - Brazil TA - Dental Press J Orthod JT - Dental press journal of orthodontics JID - 101532240 RN - WAT0DDB505 (Calcium Sulfate) SB - IM MH - Humans MH - *Models, Dental MH - Reproducibility of Results MH - Infant MH - Child, Preschool MH - Software MH - *Imaging, Three-Dimensional MH - Female MH - Male MH - *Odontometry/instrumentation MH - Dental Arch/anatomy & histology MH - Tooth, Deciduous/anatomy & histology MH - Calcium Sulfate PMC - PMC12904138 EDAT- 2026/02/19 17:35 MHDA- 2026/02/19 17:36 PMCR- 2026/02/09 CRDT- 2026/02/19 11:13 PHST- 2025/07/12 00:00 [received] PHST- 2025/10/06 00:00 [accepted] PHST- 2026/02/19 17:36 [medline] PHST- 2026/02/19 17:35 [pubmed] PHST- 2026/02/19 11:13 [entrez] PHST- 2026/02/09 00:00 [pmc-release] AID - S2176-94512025000600305 [pii] AID - 10.1590/2177-6709.30.6.e2525164.oar [doi] PST - epublish SO - Dental Press J Orthod. 2026 Feb 13;30(6):e2525164. doi: 10.1590/2177-6709.30.6.e2525164.oar. eCollection 2026. PMID- 41711692 OWN - NLM STAT- MEDLINE DCOM- 20261027 LR - 20261028 IS - 2156-535X (Electronic) IS - 2156-5333 (Linking) VI - 15 IP - 6 DP - 2026 Dec TI - Scoping Review of Cardiorespiratory Fitness in Adolescent and Young Adult Cancer Survivors. PG - 402-415 LID - 10.1177/21565333261424190 [doi] AB - Advancements in cancer research, treatment protocols, and supportive care interventions have contributed to an increasing population of adolescent and young adult cancer survivors (AYA-CS). Impaired cardiorespiratory fitness is a key modifiable risk factor in AYA-CS, linked to several conditions, in particular cardiovascular disease. This scoping review describes and synthesizes previously published data that has documented the cardiorespiratory fitness in AYA-CS. Secondary objectives were to synthesize the assessment methodologies used to measure cardiorespiratory fitness and to explore whether exercise interventions improve AYA-CS fitness. CINAHL, EMBASE, MEDLINE, and SPORTDiscus were systematically searched from [28/02/2025]. Original articles that assessed cardiorespiratory fitness in AYA-CS (aged between 15 and 39 at the time of cancer diagnosis and had completed treatment) were eligible. A total of 3049 articles were identified from the database search. After screening, 10 studies were included, representing 494 participants (59.7% female). AYA-CS exhibit markedly reduced cardiorespiratory fitness with peak oxygen uptake values 20-47% below healthy controls when measured via cardiopulmonary exercise test. There was wide variability in both the measures used to assess cardiorespiratory fitness and the types and mode of prescribed exercise interventions. Exercise interventions were primarily individualized and aerobic, demonstrating good feasibility and high acceptability among AYA-CS. This scoping review highlights that AYA-CS experience persistent impairments in cardiorespiratory fitness post-treatment. Future research is required to standardize fitness assessment measures, establishing cardiorespiratory fitness norms to help guide clinical interventions and the development of targeted interventions aimed at improving fitness and health outcomes. FAU - Murnane, Andrew AU - Murnane A AUID- ORCID: 0000-0002-5992-9311 AD - Victorian Adolescent and Young Adult Cancer Service, Peter MacCallum Cancer Centre, Melbourne, Australia. AD - Deakin University, Institute for Physical Activity and Nutrition (IPAN), Geelong, Australia. FAU - Lewin, Jeremy AU - Lewin J AD - Victorian Adolescent and Young Adult Cancer Service, Peter MacCallum Cancer Centre, Melbourne, Australia. AD - Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia. AD - Department of Medical Oncology, Peter MacCallum Cancer Centre, Melbourne, Australia. FAU - Kiss, Nicole AU - Kiss N AD - Deakin University, Institute for Physical Activity and Nutrition (IPAN), Geelong, Australia. AD - Allied Health Research, Peter MacCallum Cancer Centre, Melbourne, Australia. FAU - Ugalde, Anna AU - Ugalde A AD - School of Nursing and Midwifery, Institute for Health Transformation, Deakin University, Burwood, Australia. FAU - Fraser, Steve F AU - Fraser SF AD - Deakin University, Institute for Physical Activity and Nutrition (IPAN), Geelong, Australia. LA - eng PT - Journal Article PT - Review PT - Scoping Review DEP - 20260219 PL - United States TA - J Adolesc Young Adult Oncol JT - Journal of adolescent and young adult oncology JID - 101543508 SB - IM MH - Humans MH - *Cardiorespiratory Fitness/physiology MH - Adolescent MH - Young Adult MH - *Cancer Survivors MH - Female MH - Adult MH - Male OTO - NOTNLM OT - adolescent and young adults OT - assessment measures OT - cardiorespiratory fitness OT - late-effects OT - survivorship COIS- Author Disclosure StatementThe authors have no conflicts of interest to declare that are relevant to the content of this article. EDAT- 2026/02/19 17:35 MHDA- 2026/10/27 11:30 CRDT- 2026/02/19 11:03 PHST- 2026/10/27 11:30 [medline] PHST- 2026/02/19 17:35 [pubmed] PHST- 2026/02/19 11:03 [entrez] AID - 10.1177/21565333261424190 [doi] PST - ppublish SO - J Adolesc Young Adult Oncol. 2026 Dec;15(6):402-415. doi: 10.1177/21565333261424190. Epub 2026 Feb 19. PMID- 41711285 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260830 IS - 1949-0984 (Electronic) IS - 1949-0976 (Print) IS - 1949-0976 (Linking) VI - 18 IP - 1 DP - 2026 Dec 31 TI - Children's gut microbiota predicts the efficacy of obesity treatment. PG - 2631824 LID - 10.1080/19490976.2026.2631824 [doi] LID - 2631824 AB - BACKGROUND & OBJECTIVE: Responses to dietary interventions may vary depending on baseline gut microbiota composition. This study aimed to determine whether baseline gut microbiota diversity and composition predict the effectiveness of childhood obesity interventions. METHODS: Anthropometry, triglycerides, HDL-cholesterol, HOMA-IR, and systolic and diastolic blood pressure (SBP, DBP) were evaluated and standardised in 41 children with obesity (8-14yrs). Faecal samples were collected at baseline and after one year. Intervention success was defined by improvements in metabolic risk score (MetScore) or BMI z-score. Associations between baseline microbiota features (diversity and composition) and intervention success were evaluated using Spearman's correlation and linear regression models. Gut microbiota composition and differential abundance were analyzed using ANCOM-BC2. Exploratory biomarker discovery was analyzed using LEfSe, and predictive modelling using a Random Forest (RF) classifier. Receiver operating characteristic (ROC) curve analysis was used to determine a Simpson index cut-off. RESULTS: Higher baseline Shannon and Simpson indices, and greater abundances of Faecalibacterium and Eubacterium coprostanoligenes group, were associated with greater improvements in MetScore. Faecalibacterium was the most influential feature with the highest importance in the RF model, which achieved an AUC of 0.876 for MetScore and 0.873 for BMI z-score improvement. Eighty-four features differed between MetScore response groups (FDR < 0.05) with some genus-level overlap with the exploratory analysis, including Eubacterium coprostanoligenes and Ruminococcus. A Simpson index cut-off of 0.849 stratified participants high- and low-diversity groups; children above this threshold exhibited greater improvements in MetScore (p = 0.028), SBP (p = 0.043), and in HDL-cholesterol (p = 0.028). CONCLUSION: Higher baseline gut microbiota diversity and specific microbial signatures, particularly Faecalibacterium abundance, predicted better outcomes in childhood obesity interventions. These findings support the potential use of microbiota profiling to guide personalised treatment strategies. Further research is needed to optimise interventions.Trial registration: clinicaltrials.gov NCT03749291. FAU - Alcazar, Mireia AU - Alcazar M AUID- ORCID: 0000-0001-9813-4645 AD - Paediatric Nutrition and Human Development Research Unit, Universitat Rovira i Virgili, C/Sant Llorenc, 21, Reus, Spain. AD - Institut de Recerca Biomedica CatSud, Reus, Spain. FAU - Luque, Veronica AU - Luque V AUID- ORCID: 0000-0003-2615-8175 AD - Paediatric Nutrition and Human Development Research Unit, Universitat Rovira i Virgili, C/Sant Llorenc, 21, Reus, Spain. AD - Institut de Recerca Biomedica CatSud, Reus, Spain. FAU - Ferre, Natalia AU - Ferre N AUID- ORCID: 0000-0002-2838-1525 AD - Paediatric Nutrition and Human Development Research Unit, Universitat Rovira i Virgili, C/Sant Llorenc, 21, Reus, Spain. AD - Institut de Recerca Biomedica CatSud, Reus, Spain. FAU - Munoz-Hernando, Judit AU - Munoz-Hernando J AUID- ORCID: 0000-0003-2622-7011 AD - Paediatric Nutrition and Human Development Research Unit, Universitat Rovira i Virgili, C/Sant Llorenc, 21, Reus, Spain. AD - Institut de Recerca Biomedica CatSud, Reus, Spain. FAU - Gispert-Llaurado, Mariona AU - Gispert-Llaurado M AUID- ORCID: 0000-0002-4586-8079 AD - Paediatric Nutrition and Human Development Research Unit, Universitat Rovira i Virgili, C/Sant Llorenc, 21, Reus, Spain. AD - Institut de Recerca Biomedica CatSud, Reus, Spain. FAU - Closa-Monasterolo, Ricardo AU - Closa-Monasterolo R AUID- ORCID: 0000-0002-9963-4163 AD - Paediatric Nutrition and Human Development Research Unit, Universitat Rovira i Virgili, C/Sant Llorenc, 21, Reus, Spain. AD - Institut de Recerca Biomedica CatSud, Reus, Spain. FAU - Feliu, Albert AU - Feliu A AUID- ORCID: 0000-0002-5249-7907 AD - Paediatric Nutrition and Human Development Research Unit, Universitat Rovira i Virgili, C/Sant Llorenc, 21, Reus, Spain. AD - Institut de Recerca Biomedica CatSud, Reus, Spain. AD - Hospital Universitari Sant Joan de Reus, Av Dr Josep Laporte, 2, Reus, Spain. FAU - Castillejo, Gemma AU - Castillejo G AUID- ORCID: 0000-0001-6737-075X AD - Paediatric Nutrition and Human Development Research Unit, Universitat Rovira i Virgili, C/Sant Llorenc, 21, Reus, Spain. AD - Institut de Recerca Biomedica CatSud, Reus, Spain. AD - Hospital Universitari Sant Joan de Reus, Av Dr Josep Laporte, 2, Reus, Spain. FAU - Escribano, Joaquin AU - Escribano J AUID- ORCID: 0000-0002-5041-459X AD - Paediatric Nutrition and Human Development Research Unit, Universitat Rovira i Virgili, C/Sant Llorenc, 21, Reus, Spain. AD - Institut de Recerca Biomedica CatSud, Reus, Spain. AD - Hospital Universitari Sant Joan de Reus, Av Dr Josep Laporte, 2, Reus, Spain. LA - eng SI - ClinicalTrials.gov/NCT03749291 PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260219 PL - United States TA - Gut Microbes JT - Gut microbes JID - 101495343 SB - IM MH - Humans MH - *Gastrointestinal Microbiome MH - Child MH - Female MH - Feces/microbiology MH - Male MH - Adolescent MH - *Bacteria/classification/isolation & purification/genetics MH - *Pediatric Obesity/microbiology/diet therapy/metabolism MH - Treatment Outcome MH - Body Mass Index PMC - PMC12928635 OTO - NOTNLM OT - Obesity OT - children OT - gut microbiota OT - intervention OT - weight loss COIS- The authors declare no conflicts of interest. EDAT- 2026/02/19 17:35 MHDA- 2026/02/19 17:36 PMCR- 2026/02/19 CRDT- 2026/02/19 07:24 PHST- 2026/02/19 17:36 [medline] PHST- 2026/02/19 17:35 [pubmed] PHST- 2026/02/19 07:24 [entrez] PHST- 2026/02/19 00:00 [pmc-release] AID - 2631824 [pii] AID - 10.1080/19490976.2026.2631824 [doi] PST - ppublish SO - Gut Microbes. 2026 Dec 31;18(1):2631824. doi: 10.1080/19490976.2026.2631824. Epub 2026 Feb 19. PMID- 41711279 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260708 IS - 0035-7715 (Print) IS - 0035-7715 (Linking) VI - 76 IP - 3 DP - 2025 Nov 19 TI - Assessing the effects of social media on eating behavior in Algerian university students. PG - 211-220 LID - 210413 [pii] LID - 10.32394/rpzh/210413 [doi] AB - BACKGROUND: Social media plays a central role in the daily lives of university students, influencing various aspects of behavior, especially their eating habits. The goal of this study was to adapt and validate the scale of effects of social media on eating behavior (SESMEB), which was initially established in Turkish, for use by Algerian university students. MATERIAL AND METHODS: A cross-sectional study was conducted between March 2025 and May 2025. Participants filled out an online questionnaire covering socio-demographic data, social media usage patterns, and the SESMEB. Internal consistency was assessed using Cronbach's alpha and the Spearman-Brown coefficient was used to measure reliability. Confirmatory Factor Analysis (CFA) was used to assess construct validity, and independent t-tests were used to investigate item discrimination across extreme groups. RESULTS: The Algerian version of SESMEB demonstrated excellent internal consistency (Cronbach's alpha = 0.930). CFA confirmed a strong unidimensional structure, with factor loadings ranging from 0.49 to 0.75 and high model fit indices. SESMEB scores were significantly correlated with daily social media time (p < 0.001), indicating that higher social media engagement corresponded to a greater influence on eating behavior. CONCLUSION: The adapted SESMEB is a valid and reliable instrument for assessing the influence of social media on eating habits among Algerian university students. These findings provide a foundation for future study focused at encouraging healthy digital and nutritional behaviors among young people. FAU - Meskini, Zakaria AU - Meskini Z AD - Department of Agricultural Sciences, Laboratory of Environment, Natural Plant Substances and Food Technology, University of Relizane, Algeria. FAU - Zouaoui, Khadidja AU - Zouaoui K AD - Department of Agricultural Sciences, University of Moulay Tahar Saida, Algeria. FAU - Seddar-Yagoub, Fatima AU - Seddar-Yagoub F AD - Department of Agricultural Sciences, Laboratory of Animal Production Sciences and Techniques, University of Abdelhamid Ibn Badis, Algeria. FAU - Bounaama, Khalil AU - Bounaama K AD - Department of Agricultural Sciences, Laboratory of Animal Production Sciences and Techniques, University of Abdelhamid Ibn Badis, Algeria. FAU - Touahri, Ahmed AU - Touahri A AD - Department of Natural and Life Sciences, Agronomy Environment Laboratory, Tissemsilt University, Algeria. LA - eng PT - Journal Article DEP - 20251106 PL - Poland TA - Rocz Panstw Zakl Hig JT - Roczniki Panstwowego Zakladu Higieny JID - 0414756 SB - IM MH - Humans MH - *Feeding Behavior/psychology MH - Female MH - *Students/psychology/statistics & numerical data MH - Male MH - Algeria MH - Young Adult MH - Cross-Sectional Studies MH - Universities MH - *Social Media/statistics & numerical data MH - Surveys and Questionnaires/standards MH - Adult MH - Reproducibility of Results MH - Adolescent MH - Media Exposure MH - Digital Media OTO - NOTNLM OT - Algerian students OT - eating behavior OT - reliability OT - social media OT - validity EDAT- 2026/02/19 17:36 MHDA- 2026/02/19 17:37 CRDT- 2026/02/19 07:24 PHST- 2026/02/19 17:37 [medline] PHST- 2026/02/19 17:36 [pubmed] PHST- 2026/02/19 07:24 [entrez] AID - 210413 [pii] AID - 10.32394/rpzh/210413 [doi] PST - ppublish SO - Rocz Panstw Zakl Hig. 2025 Nov 19;76(3):211-220. doi: 10.32394/rpzh/210413. Epub 2025 Nov 6. PMID- 41711263 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Feb 19 TI - The cost of a healthy diet and its association with BMI in crisis-stricken Lebanon. PG - e42 LID - 10.1017/S1368980026102092 [doi] LID - e42 AB - OBJECTIVES: This study aimed to determine the prevalence of Lebanese adults living with underweight, overweight or obesity, assess and compare the cost of the Mediterranean Diet (MD) with that of the current dietary consumption pattern and explore diet cost as a determinant of living with underweight, overweight or obesity. DESIGN: Data for this nationally representative cross-sectional study were collected through sociodemographic questionnaires, anthropometric measurements, the Arab Family Food Security Scale and dietary assessments using a validated FFQ and 24-h recalls. Diet costs were calculated based on 2023 market prices using purchasing power parity. Logistic regression was used to assess associations with BMI. SETTING: Lebanon, using data representative of the Lebanese adults' population. PARTICIPANTS: 444 Lebanese residents aged 18-64 years. RESULTS: Overall, 66.2 % of the participants were living with underweight (4.3 %), overweight (37.8 %) or obesity (24.1 %). On average, the cost of following MD ranged from Intl.$ 23.36 to Intl.$ 26.49/person/d, whereas a Lebanese adult spent Intl.$ 20.46 on consumption. Only 31.1 % of participants spent an amount equal to or greater than the minimum MD cost (Intl. $23.36/d). Participants who meet or exceed this threshold were 1.59 times more likely to be living with a healthy weight (aOR = 1.59, p = 0.043). CONCLUSIONS: The high prevalence of Lebanese adults living with underweight, overweight or obesity is compounded by the unaffordability of a healthy MD. Improving the affordability of nutritious foods is crucial to promoting healthier dietary patterns and achieving better weight outcomes. Public health strategies should include economic, behavioural and policy-level interventions to enhance diet quality and affordability in crisis-affected populations. FAU - Hoteit, Maha AU - Hoteit M AD - Lebanese University, Lebanon. FAU - Abboud, Myriam AU - Abboud M AD - Zayed University, United Arab Emirates. FAU - Khattar, Maroun AU - Khattar M AD - Lebanese University, Lebanon. FAU - Rizk, Rana AU - Rizk R AUID- ORCID: 0000-0002-8850-6502 AD - Lebanese American Universityhttps://ror.org/00hqkan37, Lebanon. LA - eng PT - Journal Article DEP - 20260219 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Lebanon/epidemiology MH - Adult MH - Cross-Sectional Studies MH - Female MH - Male MH - *Body Mass Index MH - Middle Aged MH - Adolescent MH - *Thinness/epidemiology/economics MH - *Overweight/epidemiology/economics MH - *Obesity/epidemiology/economics MH - Young Adult MH - *Diet, Mediterranean/economics/statistics & numerical data MH - *Diet, Healthy/economics/statistics & numerical data MH - Prevalence PMC - PMC12979016 OTO - NOTNLM OT - Health OT - Lebanon OT - Mediterranean Diet OT - diet affordability OT - food insecurity OT - nutrition transition COIS- None. EDAT- 2026/02/19 17:35 MHDA- 2026/03/07 18:38 PMCR- 2026/02/19 CRDT- 2026/02/19 07:13 PHST- 2026/03/07 18:38 [medline] PHST- 2026/02/19 17:35 [pubmed] PHST- 2026/02/19 07:13 [entrez] PHST- 2026/02/19 00:00 [pmc-release] AID - S1368980026102092 [pii] AID - 10.1017/S1368980026102092 [doi] PST - epublish SO - Public Health Nutr. 2026 Feb 19;29(1):e42. doi: 10.1017/S1368980026102092. PMID- 41711017 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1942-0080 (Electronic) IS - 1941-9651 (Print) IS - 1941-9651 (Linking) VI - 19 IP - 3 DP - 2026 Mar TI - Current State of RV Multimodality Imaging in Pediatric Pulmonary Hypertension: Current Evidence, Knowledge Gaps, and Future Research Directions. PG - e019264 LID - 10.1161/CIRCIMAGING.125.019264 [doi] AB - Right ventricular (RV) failure is a principal determinant of morbidity and mortality in children with pulmonary hypertension, making accurate RV assessment a cornerstone of risk stratification and long-term management. Noninvasive imaging plays a central role in this evaluation; however, commonly used modalities, including 2- and 3-dimensional echocardiography and cardiac magnetic resonance imaging, each have distinct advantages and limitations in the pediatric population. Consequently, an integrated, multimodal imaging strategy is required. This review provides a contemporary, critical appraisal of the existing evidence and key knowledge gaps related to noninvasive multimodality imaging of the RV in pediatric pulmonary hypertension. The discussion is structured around fundamental aspects of RV physiology, including chamber size and mass, systolic function, diastolic function and stiffness, RV-left ventricle interactions, ventriculoarterial coupling, and exercise assessment. Echocardiography and cardiac magnetic resonance imaging are presented in parallel to highlight their complementary roles within a multimodality framework. Current prognostic thresholds in pediatric pulmonary hypertension imaging are largely supported by level of evidence C, underscoring persistent gaps that limit the development of definitive clinical recommendations and a unified approach. We propose a roadmap to guide future research efforts and collaborative initiatives among pediatric pulmonary hypertension and imaging specialists, emphasizing the role of professional networks in advancing the field. FAU - Miles, Kimberley G AU - Miles KG AUID- ORCID: 0000-0003-3093-4384 AD - The Heart Institute, Cincinnati Children's Hospital Medical Center, Department of Pediatrics, University of Cincinnati College of Medicine, OH (K.G.M.). AD - Department of Pediatrics, University of Cincinnati College of Medicine, OH (K.G.M.). FAU - Dorobantu, Dan M AU - Dorobantu DM AD - Department of Cardiology, Bristol Royal Hospital for Children and Heart Institute, United Kingdom (D.M.D.). FAU - Douwes, Johannes Menno AU - Douwes JM AUID- ORCID: 0000-0003-3146-5831 AD - Department of Pediatric Cardiology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, the Netherlands (J.M.D.). FAU - Frank, Benjamin S AU - Frank BS AUID- ORCID: 0000-0002-2227-6265 AD - Section of Cardiology, Department of Pediatrics, University of Colorado Denver Anschutz Medical Center and Children's Hospital Colorado, Aurora (B.S.F., D.D.I.). FAU - Jone, Pei-Ni AU - Jone PN AUID- ORCID: 0000-0001-5145-0341 AD - Department of Cardiology, Lurie Children's Hospital, Northwestern University Feinberg School of Medicine, Chicago, IL (P.-N.J.). FAU - Muthurangu, Vivek AU - Muthurangu V AUID- ORCID: 0000-0002-4292-6456 AD - UCL Centre for Translational Cardiovascular Imaging, Institute of Cardiovascular Science, University College London, United Kingdom (V.M.). FAU - Ivy, D Dunbar AU - Ivy DD AUID- ORCID: 0000-0003-2541-3402 AD - Section of Cardiology, Department of Pediatrics, University of Colorado Denver Anschutz Medical Center and Children's Hospital Colorado, Aurora (B.S.F., D.D.I.). FAU - Nawaytou, Hythem AU - Nawaytou H AUID- ORCID: 0000-0002-9155-2665 AD - Division of Cardiology, Department of Pediatrics, University of California, San Francisco (H.N.). FAU - Friedberg, Mark K AU - Friedberg MK AUID- ORCID: 0000-0002-4108-5560 AD - Labatt Family Heart Center, The Hospital for Sick Children, and Department of Paediatrics, University of Toronto, ON, Canada (M.K.F.). LA - eng PT - Journal Article PT - Review DEP - 20260219 PL - United States TA - Circ Cardiovasc Imaging JT - Circulation. Cardiovascular imaging JID - 101479935 SB - IM MH - Humans MH - *Hypertension, Pulmonary/physiopathology/diagnostic imaging/complications/diagnosis MH - *Multimodal Imaging/trends/methods MH - Child MH - *Ventricular Function, Right MH - Predictive Value of Tests MH - Prognosis MH - *Ventricular Dysfunction, Right/physiopathology/diagnostic imaging/etiology MH - Magnetic Resonance Imaging MH - *Heart Ventricles/diagnostic imaging/physiopathology PMC - PMC12991334 OTO - NOTNLM OT - echocardiography OT - magnetic resonance imaging OT - pulmonary arterial hypertension OT - risk factors COIS- Dr Ivy is contracted through the University of Colorado as a consultant for Actelion, Merck, and GSK. The other authors report no conflicts. EDAT- 2026/02/19 07:02 MHDA- 2026/03/17 21:08 PMCR- 2026/03/16 CRDT- 2026/02/19 05:03 PHST- 2026/03/17 21:08 [medline] PHST- 2026/02/19 07:02 [pubmed] PHST- 2026/02/19 05:03 [entrez] PHST- 2026/03/16 00:00 [pmc-release] AID - CIRCCVIM-2025-019264 [pii] AID - 10.1161/CIRCIMAGING.125.019264 [doi] PST - ppublish SO - Circ Cardiovasc Imaging. 2026 Mar;19(3):e019264. doi: 10.1161/CIRCIMAGING.125.019264. Epub 2026 Feb 19. PMID- 41710594 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260219 LR - 20260813 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Is it time to align adolescent diets with the Planetary Health Diet? An observational study on early cardiovascular health. PG - 1739577 LID - 10.3389/fnut.2025.1739577 [doi] LID - 1739577 AB - BACKGROUND: As the impact of early adoption of a sustainable plant-based diet on cardiometabolic biomarkers remains unexplored, we assessed whether they are associated with the Planetary Health Diet Index (PHDI) in adolescents. METHODS: This prospective study was conducted within the SI! Program for Secondary Schools trial (SI! Program) in 886 adolescents (12 years +/- 0.4 at cohort entry; 49.1% female) followed during 4 years in Spain. The PHDI scores were derived from validated food frequency questionnaires. Multivariable-adjusted Cox proportional-hazards models (HRs) analyzed the association between PHDI and risk of new-onset high blood pressure (BP), obesity, and elevated plasma cardiometabolic biomarkers. Additionally, mixed models assessed changes in those parameters. RESULTS: High adherence to the PHDI((Q4 vs. Q1)) is associated with a reduced risk of high BP by 81% (HR: 0.19 [95% CI: 0.11, 0.34]), plasma glucose by 47% (HR: 0.53 [95% CI: 0.48, 0.58]), triglycerides (TG) by 66% (HR: 0.34 [95% CI: 0.18, 0.65]), total cholesterol by 51% (HR: 0.49 [95% CI: 0.34, 0.69]), and non-high density lipoprotein cholesterol (non-HDL-C) by 74% (HR: 0.26 [95% CI: 0.13, 0.50]) in Cox models. Mixed models show inverse associations with higher PHDI and blood glucose (-5.23 mg/dL [95% CI: -10.35, -0.10]), TG (-2.48 mg/dL [95% CI: -3.65, -1.30]), and body mass index (BMI) z-score (-0.02 [95% CI: -0.03, 0.00]). CONCLUSION: This study stands out as greater adherence to the PHDI is inversely associated with cardiometabolic biomarkers in adolescents, highlighting nutritional benefits of the Planetary Health Diet and its role in preventing the development of cardiovascular diseases and early detection. CI - Copyright (c) 2026 Murcia-Lesmes, Laveriano-Santos, Estruch, Corrado, Arancibia-Riveros, Ruiz-Leon, Casas, Camafort, Martinez-Gomez, de Cos-Gandoy, Bodega, Santos-Beneit, Fernandez-Alvira, Fernandez-Jimenez, Lamuela-Raventos and Castro-Barquero. FAU - Murcia-Lesmes, David AU - Murcia-Lesmes D AD - Polyphenol Research Group, Departament de Nutricio, Ciencies de l'Alimentacio i Gastronomia, Facultat de Farmacia i Ciencies de l'Alimentacio, Barcelona, Spain. AD - Institut de Nutricio i Seguretat Alimentaria (INSA-UB), Universitat de Barcelona, Barcelona, Spain. FAU - Laveriano-Santos, Emily P AU - Laveriano-Santos EP AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Estruch, Ramon AU - Estruch R AD - Institut de Nutricio i Seguretat Alimentaria (INSA-UB), Universitat de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. AD - Department of Internal Medicine, Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain. FAU - Corrado, Marina AU - Corrado M AD - Polyphenol Research Group, Departament de Nutricio, Ciencies de l'Alimentacio i Gastronomia, Facultat de Farmacia i Ciencies de l'Alimentacio, Barcelona, Spain. AD - Institut de Nutricio i Seguretat Alimentaria (INSA-UB), Universitat de Barcelona, Barcelona, Spain. FAU - Arancibia-Riveros, Camila AU - Arancibia-Riveros C AD - Polyphenol Research Group, Departament de Nutricio, Ciencies de l'Alimentacio i Gastronomia, Facultat de Farmacia i Ciencies de l'Alimentacio, Barcelona, Spain. AD - Institut de Nutricio i Seguretat Alimentaria (INSA-UB), Universitat de Barcelona, Barcelona, Spain. FAU - Ruiz-Leon, Ana Maria AU - Ruiz-Leon AM AD - Institut de Nutricio i Seguretat Alimentaria (INSA-UB), Universitat de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. AD - Department of Internal Medicine, Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain. FAU - Casas, Rosa AU - Casas R AD - Institut de Nutricio i Seguretat Alimentaria (INSA-UB), Universitat de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. AD - Department of Internal Medicine, Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain. FAU - Camafort, Miguel AU - Camafort M AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. AD - Department of Internal Medicine, Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain. FAU - Martinez-Gomez, Jesus AU - Martinez-Gomez J AD - Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. FAU - de Cos-Gandoy, Amaya AU - de Cos-Gandoy A AD - Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. AD - Foundation for Science, Health and Education (SHE Foundation), Barcelona, Spain. FAU - Bodega, Patricia AU - Bodega P AD - Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. AD - Foundation for Science, Health and Education (SHE Foundation), Barcelona, Spain. FAU - Santos-Beneit, Gloria AU - Santos-Beneit G AD - Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. AD - Foundation for Science, Health and Education (SHE Foundation), Barcelona, Spain. FAU - Fernandez-Alvira, Juan M AU - Fernandez-Alvira JM AD - Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. FAU - Fernandez-Jimenez, Rodrigo AU - Fernandez-Jimenez R AD - Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain. AD - CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. AD - Hospital Universitario Clinico San Carlos, IdISSC, Madrid, Spain. FAU - Lamuela-Raventos, Rosa M AU - Lamuela-Raventos RM AD - Polyphenol Research Group, Departament de Nutricio, Ciencies de l'Alimentacio i Gastronomia, Facultat de Farmacia i Ciencies de l'Alimentacio, Barcelona, Spain. AD - Institut de Nutricio i Seguretat Alimentaria (INSA-UB), Universitat de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. FAU - Castro-Barquero, Sara AU - Castro-Barquero S AD - Institut de Nutricio i Seguretat Alimentaria (INSA-UB), Universitat de Barcelona, Barcelona, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. AD - Department of Internal Medicine, Institut d'Investigacions Biomediques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, Barcelona, Spain. LA - eng PT - Journal Article DEP - 20260203 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12911428 OTO - NOTNLM OT - Planetary Diet OT - adolescents OT - cardiovascular health OT - nutritional epidemiology OT - plant-based diet OT - prevention OT - prospective study OT - sustainability COIS- RL-R reports personal fees from Cerveceros de Espana, personal fees, and others from Adventia, UNIDECO SA, Wine in Moderation, Ecoveritas S.A., outside the submitted work. RE reports grants from the Spanish government, Fundacion Dieta Mediterranea (Spain), and Cerveza y Salud (Spain), and personal fees for given lectures from Brewers of Europe (Belgium), the Fundacion Cerveza y Salud (Spain), Pernaud-Ricard (Mexico), Instituto Cervantes (Alburquerque, USA), Instituto Cervantes (Milan, Italy), Instituto Cervantes (Tokyo, Japan), Lilly Laboratories (Spain), and the Wine and Culinary International Forum (Spain), as well as non-financial support for the organization of a National Congress on Nutrition and feeding trials with products from Grand Fountain and Uriach Laboratories (Spain). The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author RC declares that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/02/19 07:03 MHDA- 2026/02/19 07:04 PMCR- 2026/02/03 CRDT- 2026/02/19 04:51 PHST- 2025/11/04 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2025/12/29 00:00 [accepted] PHST- 2026/02/19 07:04 [medline] PHST- 2026/02/19 07:03 [pubmed] PHST- 2026/02/19 04:51 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - 10.3389/fnut.2025.1739577 [doi] PST - epublish SO - Front Nutr. 2026 Feb 3;12:1739577. doi: 10.3389/fnut.2025.1739577. eCollection 2025. PMID- 41710457 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260219 LR - 20260813 IS - 2325-9671 (Print) IS - 2325-9671 (Electronic) IS - 2325-9671 (Linking) VI - 14 IP - 2 DP - 2026 Feb TI - Radiographic Predictors of Excessive Lower Limb Torsion in Patients With Recurrent Patellar Dislocation. PG - 23259671251414154 LID - 10.1177/23259671251414154 [doi] LID - 23259671251414154 AB - BACKGROUND: Recurrent patellar dislocation in children and adolescents is a multifactorial condition associated with anatomic risk factors such as patella alta, trochlear dysplasia, and torsional deformities of the lower limb. Although medial patellofemoral ligament reconstruction (MPFLR) is the standard approach, undetected torsional abnormalities may compromise outcomes. While computed tomography (CT) offers precise femoral torsion (FT) and tibial torsion (TT) evaluation, its widespread use is constrained by cost and radiation exposure. PURPOSE: To evaluate whether conventional radiographic parameters can predict excessive lower limb torsion in patients undergoing MPFLR. STUDY DESIGN: Cohort Study (Diagnosis); Level of evidence, 3. METHOD: The authors retrospectively analyzed 104 knees (70 patients) evaluated using CT for FT, TT, and combined torsion (FT+TT) between December 2016 and December 2023. Radiographic measures included the Caton-Deschamps index, congruence angle, sulcus angle, and patellar tilt angle. FT and TT were categorized as <20 degrees , 20 degrees to 30 degrees , or >30 degrees , and FT+TT as <40 degrees , 40 degrees to 50 degrees , or >50 degrees . Receiver operating characteristic (ROC) analysis and multivariate regression were used to assess the diagnostic performance of radiographic variables. RESULTS: The patellar tilt angle was significantly associated with FT (r = 0.24; P = .015) and FT+TT (r = 0.27; P = .009). ROC analysis showed the highest predictive accuracy for patellar tilt angle, with an area under the curve of 0.629 for FT >20 degrees , 0.653 for FT >30 degrees , and 0.665 for FT+TT >50 degrees . A threshold of 20 degrees was identified across categories. Body mass index (beta = -0.461; P = .019) and patellar tilt angle (beta = 0.222; P = .021) were independent predictors of FT (adjusted R (2) = 0.102). CONCLUSION: This study showed that although patellar tilt angle demonstrated the highest predictive value among evaluated parameters, its diagnostic accuracy was limited and insufficient to replace cross-sectional imaging. Comprehensive preoperative evaluation of lower limb torsion remains critical for minimizing residual instability and improving outcomes after MPFLR. CI - (c) The Author(s) 2026. FAU - Ishibashi, Kyota AU - Ishibashi K AUID- ORCID: 0000-0002-4426-2526 AD - Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. FAU - Sasaki, Eiji AU - Sasaki E AUID- ORCID: 0000-0002-4859-8473 AD - Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. FAU - Ishibashi, Hikaru Kristi AU - Ishibashi HK AD - Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. FAU - Sakamoto, Yukiko AU - Sakamoto Y AD - Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. FAU - Kimura, Yuka AU - Kimura Y AUID- ORCID: 0000-0001-6902-4850 AD - Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. FAU - Ishibashi, Yasuyuki AU - Ishibashi Y AD - Department of Orthopaedic Surgery, Hirosaki University Graduate School of Medicine, Hirosaki, Japan. LA - eng PT - Journal Article DEP - 20260216 PL - United States TA - Orthop J Sports Med JT - Orthopaedic journal of sports medicine JID - 101620522 PMC - PMC12909765 OTO - NOTNLM OT - femoral torsion OT - lower limb torsion OT - medial patellofemoral ligament reconstruction OT - patellar dislocation OT - tibial torsion COIS- The authors declared that they have no conflicts of interest in the authorship and publication of this contribution. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto. Ethical approval for this study was obtained from the Hirosaki University Ethics Committee (approval No. 2014-229). EDAT- 2026/02/19 07:03 MHDA- 2026/02/19 07:04 PMCR- 2026/02/16 CRDT- 2026/02/19 04:46 PHST- 2025/12/08 00:00 [received] PHST- 2025/12/13 00:00 [accepted] PHST- 2026/02/19 07:04 [medline] PHST- 2026/02/19 07:03 [pubmed] PHST- 2026/02/19 04:46 [entrez] PHST- 2026/02/16 00:00 [pmc-release] AID - 10.1177_23259671251414154 [pii] AID - 10.1177/23259671251414154 [doi] PST - epublish SO - Orthop J Sports Med. 2026 Feb 16;14(2):23259671251414154. doi: 10.1177/23259671251414154. eCollection 2026 Feb. PMID- 41710441 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1303-2968 (Electronic) IS - 1303-2968 (Linking) VI - 25 IP - 1 DP - 2026 Mar TI - The Role of Machine Learning in Talent Identification for Team Sports: A Systematic Review. PG - 58-83 LID - 10.52082/jssm.2026.58 [doi] AB - Talent identification (TID) in team sports is complex, influenced by biological, technical, psychological, and socio-cultural factors. Machine learning (ML) offers tools to integrate high-dimensional data, yet its applications in youth TID remain underexplored. Objectives: To systematically review ML approaches applied to youth talent identification in team sports, with emphasis on data domains, algorithms, validation strategies, and interpretability. Eligible studies included peer-reviewed quantitative research applying ML to youth athletes ( Behaviour). Evaluation will use an Interrupted Time Series (ITS) design. Participants include preconception women, pregnant women, postpartum mothers, children under 24 months, frontline workers (ASHAs, AWWs, ANMs) and facility staff. Interventions span health, nutrition, psychosocial and WaSH domains, integrated within ICDS and National Health Mission platforms. The objective is to develop an optimised model for scale-up that is sustainable, scalable and achieves high-quality population coverage. Outcomes include anaemia, low BMI and inadequate weight gain among women and children, with process indicators assessing compliance. Quantitative data will be analysed using segmented regression in R; qualitative data will undergo framework analysis; and economic evaluation will estimate incremental cost-effectiveness (S4 File: costing forms). DISCUSSION: This implementation research will generate evidence on the feasibility and scalability of integrating preconception-to-early-childhood interventions within government systems to inform national policy. REGISTRATION: CTRI/2023/10/058538 (Registered on 11/10/2023). CI - Copyright: (c) 2026 Jadaun et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Jadaun, Arun Singh AU - Jadaun AS AUID- ORCID: 0000-0001-9008-4428 AD - Society for Applied Studies, New Delhi, India. FAU - Kumar, Jaideep AU - Kumar J AUID- ORCID: 0000-0002-1190-0085 AD - Society for Applied Studies, New Delhi, India. FAU - Gadapani Pathak, Barsha AU - Gadapani Pathak B AD - Society for Applied Studies, New Delhi, India. AD - Centre for Intervention Science in Maternal and Child Health, Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. FAU - Devi, Sudha AU - Devi S AD - Office of Chief Medical Officer Una (HFW), Una, Himachal Pradesh, India. FAU - Thakur, Pradeep Kumar AU - Thakur PK AD - National Health Mission, Shimla, Himachal Pradesh, India. FAU - Beri, Gopal AU - Beri G AD - Office of Chief Medical Officer Una (HFW), Una, Himachal Pradesh, India. FAU - Dutt, Mohan AU - Dutt M AD - Women and Child Development, Shimla, Himachal Pradesh, India. FAU - Thakur, Seema AU - Thakur S AD - Women and Child Development, Shimla, Himachal Pradesh, India. FAU - Verma, Sanjiv Kumar AU - Verma SK AD - Office of Chief Medical Officer Una (HFW), Una, Himachal Pradesh, India. FAU - Mankotia, Sanjay AU - Mankotia S AD - Regional Hospital Una, Una, Himachal Pradesh, India. FAU - Chauhan, Anjali AU - Chauhan A AD - National Health Mission, Shimla, Himachal Pradesh, India. FAU - Kumar, Ravinder AU - Kumar R AD - National Health Mission, Shimla, Himachal Pradesh, India. FAU - Chaudhary, Ankit AU - Chaudhary A AUID- ORCID: 0000-0003-4951-7169 AD - Office of Chief Medical Officer Una (HFW), Una, Himachal Pradesh, India. FAU - Kalia, Richa AU - Kalia R AD - Office of Chief Medical Officer Una (HFW), Una, Himachal Pradesh, India. FAU - Sharma, Devinder AU - Sharma D AD - Society for Applied Studies, New Delhi, India. FAU - Chowdhury, Ranadip AU - Chowdhury R AD - Society for Applied Studies, New Delhi, India. FAU - Dhabhai, Neeta AU - Dhabhai N AUID- ORCID: 0000-0001-5548-2834 AD - Society for Applied Studies, New Delhi, India. FAU - Anand, Vinod Kumar AU - Anand VK AD - Society for Applied Studies, New Delhi, India. FAU - Taneja, Sunita AU - Taneja S AD - Society for Applied Studies, New Delhi, India. FAU - Bhandari, Nita AU - Bhandari N AD - Society for Applied Studies, New Delhi, India. FAU - Mazumder, Sarmila AU - Mazumder S AUID- ORCID: 0000-0003-4200-6112 AD - Society for Applied Studies, New Delhi, India. LA - eng PT - Journal Article DEP - 20260217 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - India/epidemiology MH - Infant MH - Pregnancy MH - Infant, Newborn MH - Infant, Low Birth Weight/growth & development MH - Child, Preschool MH - *Growth Disorders/prevention & control/epidemiology MH - Anemia/prevention & control MH - Research Design MH - Preconception Care PMC - PMC12912596 COIS- The authors have declared that no competing interests exist. EDAT- 2026/02/17 18:53 MHDA- 2026/02/17 18:54 PMCR- 2026/02/17 CRDT- 2026/02/17 13:34 PHST- 2025/12/25 00:00 [received] PHST- 2025/12/30 00:00 [accepted] PHST- 2026/02/17 18:54 [medline] PHST- 2026/02/17 18:53 [pubmed] PHST- 2026/02/17 13:34 [entrez] PHST- 2026/02/17 00:00 [pmc-release] AID - PONE-D-25-60614 [pii] AID - 10.1371/journal.pone.0341048 [doi] PST - epublish SO - PLoS One. 2026 Feb 17;21(2):e0341048. doi: 10.1371/journal.pone.0341048. eCollection 2026. PMID- 41701310 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260709 IS - 0974-7559 (Electronic) IS - 0019-6061 (Linking) VI - 63 IP - 5 DP - 2026 May TI - Clinical Course and Predictors of Metabolic Dysfunction Associated Steatotic Liver Disease in Obese Children and Adolescents. PG - 353-356 LID - 10.1007/s13312-026-00291-x [doi] AB - OBJECTIVES: To evaluate the course and predictors of outcome of metabolic dysfunction-associated steatotic liver disease (MASLD). METHODS: Records of 100 obese children with MASLD were reviewed for change in body mass index (BMI) and alanine aminotransferase (ALT) levels. RESULTS: A total of 100 (73 boys) children with mean (SD) age 12.1 (2.8) years followed for 2.0 (1.6) years were included. Normalization in ALT levels occurred in 72 (72%) at 1.1 (0.8) years of follow-up; 17 (23.6%) relapsed after 1.6 (1.3) years. Sustained remission (n = 55; 55%) was associated with greater BMI Z-score reduction (%) [median (q1, q3) 15.3 (5.1, 25.5) vs. 3.4 (- 4.3, 11.1); P < 0.001]. Multivariate regression identified BMI Z-score reduction as the only predictor of remission (OR 6.67, 95%CI 1.54-33.3; P = 0.007). ROC analysis showed BMI Z-score reduction of 13.8% predicted remission with an area under curve of 0.72 (95%CI: 0.62, 0.82; P < 0.001). CONCLUSION: Pediatric MASLD has a variable course, with remission dependent on the reduction in BMI Z-score. CI - (c) 2026. The Author(s), under exclusive licence to Indian Academy of Pediatrics. FAU - Narayanan, R AU - Narayanan R AD - Departments of Pediatric Endocrinology, Regency Hospital Limited, Uttar Pradesh, Kanpur, India. FAU - Yadav, Vibha AU - Yadav V AD - Departments of Pediatric Endocrinology, Regency Hospital Limited, Uttar Pradesh, Kanpur, India. FAU - Agarwal, Jaya AU - Agarwal J AD - Departments of Gastroenterology, Regency Hospital Limited, Uttar Pradesh, Kanpur, India. FAU - Shukla, Rishi AU - Shukla R AD - Departments of Pediatric Endocrinology, Regency Hospital Limited, Uttar Pradesh, Kanpur, India. FAU - Bajpai, Anurag AU - Bajpai A AUID- ORCID: 0000-0002-3701-2780 AD - Departments of Pediatric Endocrinology, Regency Hospital Limited, Uttar Pradesh, Kanpur, India. dranurag.bajpai@gmail.com. LA - eng PT - Journal Article DEP - 20260217 PL - India TA - Indian Pediatr JT - Indian pediatrics JID - 2985062R RN - EC 2.6.1.2 (Alanine Transaminase) SB - IM MH - Humans MH - Child MH - Male MH - *Fatty Liver/etiology/diagnosis MH - Body Mass Index MH - Female MH - Adolescent MH - Alanine Transaminase/blood MH - *Obesity/complications MH - Retrospective Studies MH - Metabolic Syndrome MH - ROC Curve OTO - NOTNLM OT - Adiposity OT - Body mass index OT - MASLD OT - Metabolic syndrome OT - Obesity COIS- Conflict of interest: None Ethics Approval Institutional Ethics Committee, Regency Healthcare, Kanpur; Ref. No. IEC Number RHL-IEC-160109 dated January 09, 2024. EDAT- 2026/02/17 17:31 MHDA- 2026/04/27 12:34 CRDT- 2026/02/17 11:06 PHST- 2025/08/30 00:00 [received] PHST- 2026/02/01 00:00 [accepted] PHST- 2026/04/27 12:34 [medline] PHST- 2026/02/17 17:31 [pubmed] PHST- 2026/02/17 11:06 [entrez] AID - 10.1007/s13312-026-00291-x [pii] AID - 10.1007/s13312-026-00291-x [doi] PST - ppublish SO - Indian Pediatr. 2026 May;63(5):353-356. doi: 10.1007/s13312-026-00291-x. Epub 2026 Feb 17. PMID- 41700575 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260819 IS - 1469-493X (Electronic) IS - 1361-6137 (Linking) VI - 2 IP - 2 DP - 2026 Feb 17 TI - Interventions for fatigue management after traumatic brain injury. PG - CD006448 LID - 10.1002/14651858.CD006448.pub2 [doi] LID - CD006448 AB - RATIONALE: Despite the high prevalence and medico-social significance of fatigue in post-traumatic brain injury (post-TBI) populations, there are no validated management strategies to control this condition. It is timely to provide clinicians and patients with the best available evidence of the efficacy of current pharmacological and non-pharmacological fatigue management practices. OBJECTIVES: To assess the effectiveness of pharmacological and non-pharmacological interventions for fatigue in people who have experienced a TBI. SEARCH METHODS: For this review, we searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, and PsycINFO. We also searched relevant conference proceedings, and we searched ClinicalTrials.gov and the WHO International Clinical Trials Registry Platform (ICTRP) for ongoing trials. The most recent searches were conducted on 12 February 2025. ELIGIBILITY CRITERIA: Eligible study designs were randomised controlled trials (RCTs) and randomised cross-over trials (for pharmacological interventions only). Studies with participants of all ages (children and adults) with a TBI (of any severity) were included, where at least 75% of participants had a TBI. Any type of treatment for fatigue was considered. Four categories of interventions were prioritised: pharmacological, cognitive, stimulation/biofeedback, and psychoeducational. These interventions were compared to placebo groups, no treatment, or groups receiving other interventions. OUTCOMES: The critical outcome was fatigue. Important outcomes include fatigue-related outcomes of psychological functioning (depression and anxiety), cognitive functioning (processing speed), general quality of life, and daytime sleepiness. RISK OF BIAS: We assessed risk of bias using the original Cochrane risk of bias tool for RCTs (RoB 1). SYNTHESIS METHODS: We synthesised the results for each outcome by meta-analysis where possible using mean differences (MDs) and standardised mean differences (SMDs) and a fixed-effect model. Where meta-analysis was not possible due to the nature of the data, we narratively reported the results. We used GRADE to assess the certainty of evidence for each outcome. We performed all statistical analyses using RevMan and presented results with 95% confidence intervals (CI). INCLUDED STUDIES: We included a total of 3518 trial participants (at baseline) across 40 studies, described in 49 publications. The 40 included studies are grouped by type of intervention. There were seven categories of interventions: pharmacological, cognitive, physical activity, stimulation/biofeedback, health visits, psychoeducational, and a final category for trials with multiple interventions (multi-interventions). Four published studies identified in the most recent search are awaiting classification. SYNTHESIS OF RESULTS: Pharmacological interventions (melatonin; recombinant human growth hormones (rhGH); psychostimulants; atorvastatin; monoaminergic stabiliser (-)-OSU6162) likely reduce fatigue slightly (SMD -0.25, 95% CI -0.44 to -0.06; 8 studies, 395 participants; moderate-certainty evidence). Cognitive interventions (cognitive rehabilitation; technology-enhanced training; functional skills training) may reduce fatigue slightly (MD -0.32, 95% CI -0.59 to -0.06; 6 studies, 222 participants; low-certainty evidence). Stimulation/biofeedback interventions (light therapy; electrical/magnetic stimulation; acupressure) may reduce fatigue slightly, but the evidence is very uncertain (SMD -0.23, 95% CI -0.47 to 0.01; 8 studies, 295 participants; very low-certainty evidence). Psychoeducation interventions (cognitive behavioural therapy; acceptance and commitment therapy; individualised occupational therapy; novel therapies) may reduce fatigue, but the evidence is very uncertain (SMD -0.55, 95% CI -0.74 to -0.35; 8 studies, 474 participants; very low-certainty evidence). There may be little to no difference in psychological functioning (depression), psychological functioning (anxiety), cognitive functioning (processing speed), or daytime sleepiness. However, these results are very uncertain. AUTHORS' CONCLUSIONS: There is very limited and moderate to very low-certainty evidence from RCTs about treatments to reduce fatigue after TBI. Despite the prevalence of fatigue post-TBI, we lack high-quality studies that evaluate interventions to improve this disabling, but potentially treatable, symptom. There is a need for considerable further work to identify an effective treatment for fatigue in people with TBI. FUNDING: This Cochrane review had no dedicated funding. REGISTRATION: Protocol available via DOI: 10.1002/14651858.CD006448. CI - Copyright (c) 2026 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd. FAU - Senior, Hugh E AU - Senior HE AUID- ORCID: 0000-0002-7081-2499 AD - School of Health Sciences, College of Health, Massey University, Auckland, New Zealand. FAU - Leung, Joan H AU - Leung JH AUID- ORCID: 0000-0002-4090-6179 AD - School of Psychology, The University of Auckland, Auckland, New Zealand. AD - Centre for Brain Research, The University of Auckland, Auckland, New Zealand. FAU - Meehan, Brigette AU - Meehan B AUID- ORCID: 0009-0009-7531-4526 AD - interRAI New Zealand, Te Whatu Ora - Health New Zealand, Wellington, New Zealand. FAU - Leao, Sylvia AU - Leao S AUID- ORCID: 0000-0002-8792-848X AD - School of Psychology, The University of Auckland, Auckland, New Zealand. FAU - Jordan, Vanessa AU - Jordan V AUID- ORCID: 0000-0002-9079-6457 AD - Department of Obstetrics and Gynaecology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. FAU - Barker-Collo, Suzanne AU - Barker-Collo S AUID- ORCID: 0000-0002-8659-0202 AD - School of Psychology, The University of Auckland, Auckland, New Zealand. FAU - Crummey, Sarah AU - Crummey S AUID- ORCID: 0000-0003-0547-0338 AD - School of Psychology, The University of Auckland, Auckland, New Zealand. FAU - Purdy, Suzanne C AU - Purdy SC AUID- ORCID: 0000-0001-9978-8173 AD - School of Psychology, The University of Auckland, Auckland, New Zealand. AD - Centre for Brain Research, The University of Auckland, Auckland, New Zealand. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260217 PL - England TA - Cochrane Database Syst Rev JT - The Cochrane database of systematic reviews JID - 100909747 SB - IM UOF - doi: 10.1002/14651858.CD006448 MH - Adult MH - Child MH - Humans MH - Bias MH - *Brain Injuries, Traumatic/complications MH - Cognitive Behavioral Therapy MH - Depression/therapy MH - *Fatigue/therapy/etiology MH - Quality of Life MH - Randomized Controlled Trials as Topic PMC - PMC12910673 COIS- Vanessa Jordan is a Cochrane editor, but was not involved in the editorial process. All other authors: no interests to declare. EDAT- 2026/02/17 17:31 MHDA- 2026/02/17 17:32 PMCR- 2027/02/17 CRDT- 2026/02/17 06:43 PHST- 2026/02/17 17:32 [medline] PHST- 2026/02/17 17:31 [pubmed] PHST- 2026/02/17 06:43 [entrez] PHST- 2027/02/17 00:00 [pmc-release] AID - CD006448.pub2 [pii] AID - 10.1002/14651858.CD006448.pub2 [doi] PST - epublish SO - Cochrane Database Syst Rev. 2026 Feb 17;2(2):CD006448. doi: 10.1002/14651858.CD006448.pub2. PMID- 41700505 OWN - NLM STAT- MEDLINE DCOM- 20260611 LR - 20260611 IS - 1098-108X (Electronic) IS - 0276-3478 (Linking) VI - 59 IP - 6 DP - 2026 Jun TI - Family-Based Treatment + Unified Protocol for Avoidant/Restrictive Food Intake Disorder: An Exploratory Feasibility and Treatment Response Study in a Case Series of Adolescents. PG - 1379-1386 LID - 10.1002/eat.70061 [doi] AB - OBJECTIVE: This study explored the flexible use of family-based treatment (FBT) and the unified protocol for the transdiagnostic treatment of emotional disorders in adolescents (FBT + UP-A) to address the diverse needs of those with avoidant/restrictive food intake disorder (ARFID). METHOD: Adolescents (n = 13, age range 13-18 years) diagnosed with ARFID were sequentially recruited from a publicly funded eating disorder program and were offered 9 months of outpatient treatment. After achieving initial weight gain using FBT, adolescents were given the option to receive the UP-A to work on self-identified treatment goals. RESULTS: The study enrolled 100% of eligible participants and all completed treatment. All participants received the minimum required dose of FBT and most chose to engage in UP-A (84.62%). Completion of research measures was inconsistent across participants and those choosing FBT-only were lost to research follow-up. Exploratory analysis of treatment response pre-to post-treatment demonstrated moderate to large treatment effect sizes in terms of weight, ARFID symptoms, and depression, but only small effect sizes for anxiety. DISCUSSION: The current study explored the sequential use of an eating disorder and a transdiagnostic emotional disorder intervention for the treatment of ARFID and co-occurring emotional concerns identified by adolescents. These findings suggest that FBT + UP-A has the potential to treat ARFID and depression but requires further testing in a larger controlled study. CI - (c) 2026 Wiley Periodicals LLC. FAU - Burton, Claire AU - Burton C AUID- ORCID: 0000-0002-8179-4812 AD - The Royal Children's Hospital Melbourne, Melbourne, Victoria, Australia. AD - Murdoch Children's Research Institute, Melbourne, Victoria, Australia. AD - The University of Melbourne, Melbourne, Victoria, Australia. FAU - Crowe, Louise AU - Crowe L AUID- ORCID: 0000-0003-4619-9708 AD - Murdoch Children's Research Institute, Melbourne, Victoria, Australia. AD - The University of Melbourne, Melbourne, Victoria, Australia. FAU - Allan, Erica AU - Allan E AUID- ORCID: 0000-0001-9946-032X AD - The Royal Children's Hospital Melbourne, Melbourne, Victoria, Australia. FAU - Singh, Manya AU - Singh M AUID- ORCID: 0009-0003-1058-6615 AD - University of Calgary, Calgary, Alberta, Canada. FAU - Eckhardt, Sarah AU - Eckhardt S AUID- ORCID: 0000-0003-0824-4328 AD - Children's Minnesota, St. Paul, Minnesota, USA. FAU - Le Grange, Daniel AU - Le Grange D AUID- ORCID: 0000-0001-7293-9496 AD - University of California, San Francisco, California, USA. FAU - Ehrenreich-May, Jill AU - Ehrenreich-May J AUID- ORCID: 0000-0001-7436-5393 AD - University of Miami, Coral Gables, Florida, USA. FAU - Finchett, Chelsea AU - Finchett C AUID- ORCID: 0009-0000-2829-4299 AD - Murdoch Children's Research Institute, Melbourne, Victoria, Australia. FAU - Sawyer, Susan AU - Sawyer S AUID- ORCID: 0000-0002-9095-358X AD - Murdoch Children's Research Institute, Melbourne, Victoria, Australia. AD - The University of Melbourne, Melbourne, Victoria, Australia. FAU - Dimitropoulos, Gina AU - Dimitropoulos G AUID- ORCID: 0000-0001-9487-0290 AD - University of Calgary, Calgary, Alberta, Canada. LA - eng GR - Murdoch Children's Research Institute/ PT - Journal Article DEP - 20260217 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - Adolescent MH - *Family Therapy/methods MH - Female MH - Male MH - *Avoidant Restrictive Food Intake Disorder/therapy/psychology MH - Feasibility Studies MH - Treatment Outcome MH - *Feeding and Eating Disorders/therapy/psychology OTO - NOTNLM OT - adolescent OT - avoidant restrictive food intake disorder OT - evidence-based treatments OT - transdiagnostic treatment EDAT- 2026/02/17 17:31 MHDA- 2026/06/11 06:38 CRDT- 2026/02/17 06:13 PHST- 2026/01/29 00:00 [revised] PHST- 2025/08/28 00:00 [received] PHST- 2026/02/05 00:00 [accepted] PHST- 2026/06/11 06:38 [medline] PHST- 2026/02/17 17:31 [pubmed] PHST- 2026/02/17 06:13 [entrez] AID - 10.1002/eat.70061 [doi] PST - ppublish SO - Int J Eat Disord. 2026 Jun;59(6):1379-1386. doi: 10.1002/eat.70061. Epub 2026 Feb 17. PMID- 41699116 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20261009 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 3 DP - 2026 Feb 16 TI - Incidence and risk factors of respiratory events after tonsillectomy for obstructive sleep apnea in children with a preoperative indication of intensive care unit admission. PG - 135 LID - 10.1007/s00431-026-06796-8 [doi] AB - Postoperative respiratory events are a common complication of tonsillectomy for pediatric obstructive sleep apnea (OSA). Despite identified risk factors, there are no validated criteria for systematic postoperative intensive care unit (ICU) admission. In France, an apnea-hypopnea index (AHI) >/= 10 events/h is a recommended criterion. This study aimed to assess the incidence and risk factors of early postoperative respiratory complications in children undergoing tonsillectomy for OSA with planned ICU admission. We conducted an observational study of children undergoing tonsillectomy between January 2020 and December 2022, with a preoperative ICU indication. Respiratory events were defined as a need of oxygen therapy, noninvasive ventilation (NIV), or tracheal intubation. Collected data included anthropometrics, comorbidities, AHI, gas exchange parameters, and surgical details. Univariate and multivariate analyses were performed for potential risk factors associated with postoperative respiratory complications. 166 children were included (median age 3 years [IQR 2-5]). The median preoperative AHI was 25 events/hour [13-43]. Overall, 159 (96%) patients had at least one comorbidity (45 Down syndrome, 31 obesity and 25 craniofacial malformations). Thirty-four (21%) patients had a respiratory complication: 30 needed oxygen therapy, 4 required NIV. None required an intubation. Age (p < 0.001), percentage of sleep time spent with an Oxygen saturation level < 85% (T85) and < 90% (T90) (p = 0.02 and p = 0.03, respectively) and McGill Oximetry Score (p = 0.01) were significantly associated with respiratory events, whereas neither AHI nor comorbidities showed a significant association. Conclusion: This study highlights the limited value of AHI alone in predicting respiratory complications post-tonsillectomy. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Gozlan, Romane AU - Gozlan R AD - Pediatric Otolaryngology Department, APHP, Hopital Necker-Enfants Malades, 149 Rue de Sevres, 75015, Paris, France. FAU - Lisan, Quentin AU - Lisan Q AD - Otolaryngology Department, Foch Hospital, 92150, Suresnes, France. FAU - Vergnaud, Estelle AU - Vergnaud E AD - Department of Paediatric Anaesthesia and Intensive Care, APHP, Hopital Necker-Enfants Malades, 75015, Paris, France. FAU - Crowe, Ann-Marie AU - Crowe AM AD - Department of Paediatric Anaesthesia and Intensive Care, APHP, Hopital Necker-Enfants Malades, 75015, Paris, France. FAU - Griffon, Lucie AU - Griffon L AD - Pediatric Sleep and Noninvasive Ventilation Unit, AP-HP, Hopital Necker-Enfants Malades, 75015, Paris, France. FAU - Fauroux, Brigitte AU - Fauroux B AD - Pediatric Sleep and Noninvasive Ventilation Unit, AP-HP, Hopital Necker-Enfants Malades, 75015, Paris, France. AD - UMR 7330 VIFASOM (Vigilance Fatigue Sommeil Et Sante Publique), Paris Cite University, 75006, Paris, France. FAU - Couloigner, Vincent AU - Couloigner V AD - Pediatric Otolaryngology Department, APHP, Hopital Necker-Enfants Malades, 149 Rue de Sevres, 75015, Paris, France. AD - Faculte de Medecine, Paris Cite University, 75006, Paris, France. FAU - Orliaguet, Gilles AU - Orliaguet G AD - Department of Paediatric Anaesthesia and Intensive Care, APHP, Hopital Necker-Enfants Malades, 75015, Paris, France. AD - Faculte de Medecine, Paris Cite University, 75006, Paris, France. AD - UMR7323 << Pharmacologie Et Evaluation Des Therapeutiques Chez L'enfant Et La Femme Enceinte >>, INSERM, Universite Paris Cite, Paris, France. FAU - Thierry, Briac AU - Thierry B AD - Pediatric Otolaryngology Department, APHP, Hopital Necker-Enfants Malades, 149 Rue de Sevres, 75015, Paris, France. AD - Faculte de Medecine, Paris Cite University, 75006, Paris, France. FAU - Luscan, Romain AU - Luscan R AUID- ORCID: 0000-0003-1219-727X AD - Pediatric Otolaryngology Department, APHP, Hopital Necker-Enfants Malades, 149 Rue de Sevres, 75015, Paris, France. romain.luscan@aphp.fr. AD - Faculte de Medecine, Paris Cite University, 75006, Paris, France. romain.luscan@aphp.fr. LA - eng PT - Journal Article PT - Observational Study DEP - 20260216 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - *Tonsillectomy/adverse effects MH - *Sleep Apnea, Obstructive/surgery MH - Risk Factors MH - Female MH - Incidence MH - Child, Preschool MH - Male MH - *Postoperative Complications/epidemiology/etiology MH - France/epidemiology MH - Child OTO - NOTNLM OT - Apnea-hypopnea index OT - Intensive care unit OT - McGill score OT - Oximetry OT - Pediatric OSA OT - Respiratory events OT - Tonsillectomy COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/02/17 00:53 MHDA- 2026/02/17 00:54 CRDT- 2026/02/16 23:26 PHST- 2025/12/17 00:00 [received] PHST- 2026/02/09 00:00 [accepted] PHST- 2026/02/02 00:00 [revised] PHST- 2026/02/17 00:54 [medline] PHST- 2026/02/17 00:53 [pubmed] PHST- 2026/02/16 23:26 [entrez] AID - 10.1007/s00431-026-06796-8 [pii] AID - 10.1007/s00431-026-06796-8 [doi] PST - epublish SO - Eur J Pediatr. 2026 Feb 16;185(3):135. doi: 10.1007/s00431-026-06796-8. PMID- 41699110 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260920 IS - 1433-7339 (Electronic) IS - 0941-4355 (Print) IS - 0941-4355 (Linking) VI - 34 IP - 3 DP - 2026 Feb 17 TI - Lipidomic profiles associated with treatment related hepatotoxicity in children with acute lymphoblastic leukemia. PG - 209 LID - 10.1007/s00520-026-10414-6 [doi] LID - 209 AB - INTRODUCTION: Treatment for childhood acute lymphoblastic leukemia (ALL) can result in hepatotoxicity. Despite being a common complication of ALL therapy, mechanisms and biomarkers of treatment-associated hepatotoxicity (TAH) are not well described. METHODS: We conducted lipidomic profiling to identify plasma lipids associated with TAH in children receiving ALL therapy utilizing a nested case-control framework. TAH was defined as (1) transaminitis: ALT/AST >/= CTCAE grade 3, and/or (2) conjugated hyperbilirubinemia: > 3.0 mg/dL during induction therapy or > 2.0 mg/dL post induction. A total of 90 patients (45 matched pairs) treated at Texas Children's Hospital between 2012 and 2021 were selected for lipidomic profiling, with controls matched to cases based on the availability of samples collected at similar time points in therapy. Lipidomic profiling quantified 1056 lipids, with 751 retained after quality control. Associations with TAH were evaluated using multivariable conditional logistic regression controlling for age, diagnostic BMI z-score, race/ethnicity, and induction intensity. RESULTS: The cohort was 55% male, 50% Hispanic, with a mean diagnostic age of 5 years. We identified 110 lipids nominally associated with TAH post-sample collection (p < 0.05). Lipid classes phosphatidylcholines (PCs; Holm-p = 5 x 10(-6)) and sphingomyelins (SMs; Holm-p = 0.0009) were significantly enriched in cases. DISCUSSION: We identified plasma lipid profiles, characterized by elevated PCs and SMs with reduced triglycerides, associated with the incidence of TAH in children with ALL. Similar patterns have been linked to metabolic liver disease in adults and children. These findings suggest lipid dysregulation may contribute to TAH susceptibility and highlight candidate biomarkers for future validation in larger cohorts. CI - (c) 2026. The Author(s). FAU - Mason, Emily J AU - Mason EJ AD - Baylor College of Medicine, One Baylor Plaza, BCM 622, Houston, TX, 77030, USA. AD - Texas Children's Cancer and Hematology Center, Houston, TX, USA. FAU - Schraw, Jeremy M AU - Schraw JM AD - Baylor College of Medicine, One Baylor Plaza, BCM 622, Houston, TX, 77030, USA. AD - Texas Children's Cancer and Hematology Center, Houston, TX, USA. FAU - Woodhouse, John P AU - Woodhouse JP AD - Baylor College of Medicine, One Baylor Plaza, BCM 622, Houston, TX, 77030, USA. AD - Texas Children's Cancer and Hematology Center, Houston, TX, USA. FAU - Gramatges, M Monica AU - Gramatges MM AD - Baylor College of Medicine, One Baylor Plaza, BCM 622, Houston, TX, 77030, USA. AD - Texas Children's Cancer and Hematology Center, Houston, TX, USA. FAU - Williams, Kevin J AU - Williams KJ AD - University of California Los Angeles, Los Angeles, CA, USA. FAU - Chen, Baojiang AU - Chen B AD - University of Texas School of Public Health, Houston, TX, USA. FAU - Harrell, Melissa B AU - Harrell MB AD - University of Texas School of Public Health, Houston, TX, USA. FAU - Taylor, Olga A AU - Taylor OA AD - Emory School of Medicine, Atlanta, GA, USA. FAU - Scheurer, Michael E AU - Scheurer ME AD - Emory School of Medicine, Atlanta, GA, USA. FAU - Lupo, Philip J AU - Lupo PJ AD - Emory School of Medicine, Atlanta, GA, USA. FAU - Rabin, Karen R AU - Rabin KR AD - University of California San Francisco, San Francisco, CA, USA. FAU - Yi, Joanna S AU - Yi JS AD - Baylor College of Medicine, One Baylor Plaza, BCM 622, Houston, TX, 77030, USA. AD - Texas Children's Cancer and Hematology Center, Houston, TX, USA. FAU - Huynh, Van AU - Huynh V AD - Children's Hospital of Orange County (CHOC), Orange, CA, USA. FAU - Mittelman, Steven D AU - Mittelman SD AD - University of California Los Angeles, Los Angeles, CA, USA. FAU - Orgel, Etan AU - Orgel E AD - Children's Hospital of Los Angeles, Los Angeles, CA, USA. FAU - Brown, Austin AU - Brown A AD - Baylor College of Medicine, One Baylor Plaza, BCM 622, Houston, TX, 77030, USA. austin.brown@bcm.edu. AD - Texas Children's Cancer and Hematology Center, Houston, TX, USA. austin.brown@bcm.edu. LA - eng GR - P20 CA262733/CA/NCI NIH HHS/United States GR - U54 CA302464/CA/NCI NIH HHS/United States GR - UH3 CA260607/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20260217 PL - Germany TA - Support Care Cancer JT - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer JID - 9302957 RN - 0 (Lipids) RN - 0 (Biomarkers) RN - 0 (Antineoplastic Agents) SB - IM MH - Humans MH - *Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy MH - Male MH - Child, Preschool MH - Female MH - *Lipidomics MH - *Chemical and Drug Induced Liver Injury/etiology/epidemiology/blood MH - Child MH - Case-Control Studies MH - Infant MH - *Lipids/blood MH - Biomarkers/blood MH - Adolescent MH - *Antineoplastic Agents/adverse effects MH - Texas MH - Logistic Models PMC - PMC12909625 OTO - NOTNLM OT - Acute lymphoblastic leukemia OT - Lipidomic profiling OT - Treatment-associated hepatotoxicity COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/02/17 00:53 MHDA- 2026/02/17 00:54 PMCR- 2026/02/17 CRDT- 2026/02/16 23:26 PHST- 2025/11/20 00:00 [received] PHST- 2026/01/29 00:00 [accepted] PHST- 2026/02/17 00:54 [medline] PHST- 2026/02/17 00:53 [pubmed] PHST- 2026/02/16 23:26 [entrez] PHST- 2026/02/17 00:00 [pmc-release] AID - 10.1007/s00520-026-10414-6 [pii] AID - 10414 [pii] AID - 10.1007/s00520-026-10414-6 [doi] PST - epublish SO - Support Care Cancer. 2026 Feb 17;34(3):209. doi: 10.1007/s00520-026-10414-6. PMID- 41699091 OWN - NLM STAT- MEDLINE DCOM- 20261020 LR - 20261022 IS - 1476-5543 (Electronic) IS - 0743-8346 (Linking) VI - 46 IP - 10 DP - 2026 Oct TI - Predicting pulmonary hypertension in infants with bronchopulmonary dysplasia. PG - 1915-1921 LID - 10.1038/s41372-026-02576-2 [doi] AB - OBJECTIVE: Develop and validate predictive models for pulmonary hypertension (PH) in high-risk infants. STUDY DESIGN: We trained logistic regression (LR) and long short-term memory (LSTM) models using a multicenter cohort study of infants 22-28 weeks gestational age discharged from neonatal intensive care units from 2008 to 2020, at two timepoints: 33 weeks post-menstrual age (PMA) for infants receiving mechanical ventilation at that time, and 36 weeks PMA for infants receiving any respiratory support at that time. RESULTS: At 33 weeks PMA (N = 2849), top LR model predictors were current fraction of inspired oxygen and birth weight. At 36 weeks (N = 20,173), top LR model predictors were current respiratory support and birth weight. Both LR and LSTM models had strong performance in the temporal validation cohort (infants discharged 2021-2022) for both timepoints. CONCLUSION: Using available clinical variables, we developed and validated predictive models that may identify infants most at risk for PH at two timepoints. CI - (c) 2026. The Author(s). FAU - Foote, Henry P AU - Foote HP AD - Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. FAU - Sun, Minghui AU - Sun M AUID- ORCID: 0009-0005-0497-4464 AD - Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA. FAU - Goldstein, Benjamin Alan AU - Goldstein BA AD - Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA. FAU - Hill, Kevin D AU - Hill KD AD - Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. AD - Duke Clinical Research Institute, Durham, NC, USA. FAU - Greenberg, Rachel G AU - Greenberg RG AUID- ORCID: 0000-0003-4156-8543 AD - Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. AD - Duke Clinical Research Institute, Durham, NC, USA. FAU - Gentle, Samuel J AU - Gentle SJ AUID- ORCID: 0000-0003-0238-6472 AD - Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA. FAU - Zimmerman, Kanecia O AU - Zimmerman KO AD - Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. AD - Duke Clinical Research Institute, Durham, NC, USA. FAU - Kamaleswaran, Rishikesan AU - Kamaleswaran R AD - Department of Surgery, Duke University Medical Center, Durham, NC, USA. AD - Department of Electrical and Computer Engineering, Duke University, Durham, NC, USA. FAU - Tolia, Veeral N AU - Tolia VN AD - Pediatrix Center for Research, Quality, Education and Safety, Sunrise, FL, USA. AD - Department of Pediatrics, Baylor University Medical Center, Dallas, TX, USA. FAU - Laughon, Matthew M AU - Laughon MM AUID- ORCID: 0000-0002-4052-3215 AD - Department of Pediatrics, School of Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC, USA. FAU - Jackson, Wesley AU - Jackson W AUID- ORCID: 0000-0002-9403-381X AD - Department of Pediatrics, School of Medicine, University of North Carolina Chapel Hill, Chapel Hill, NC, USA. FAU - Hornik, Christoph P AU - Hornik CP AUID- ORCID: 0000-0001-7056-8759 AD - Department of Pediatrics, Duke University Medical Center, Durham, NC, USA. christoph.hornik@duke.edu. AD - Duke Clinical Research Institute, Durham, NC, USA. christoph.hornik@duke.edu. LA - eng GR - T32 HD104576/HD/NICHD NIH HHS/United States GR - K24 HL173596/HL/NHLBI NIH HHS/United States GR - 1K24HL173596/U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)/ GR - K23 HD113837/HD/NICHD NIH HHS/United States GR - 1T32HD104576/U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)/ GR - R33 HL147833/HL/NHLBI NIH HHS/United States GR - R01 GM139967/GM/NIGMS NIH HHS/United States GR - 5R33HL147833/U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI)/ GR - T32HD094671/U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)/ GR - K23 HD111623/HD/NICHD NIH HHS/United States GR - T32 HD094671/HD/NICHD NIH HHS/United States PT - Journal Article PT - Multicenter Study DEP - 20260216 PL - United States TA - J Perinatol JT - Journal of perinatology : official journal of the California Perinatal Association JID - 8501884 SB - IM MH - Female MH - Humans MH - Infant, Newborn MH - Male MH - Birth Weight MH - *Bronchopulmonary Dysplasia/complications/therapy MH - Gestational Age MH - *Hypertension, Pulmonary/etiology/diagnosis MH - Infant, Premature MH - Intensive Care Units, Neonatal MH - Logistic Models MH - Long Short Term Memory MH - Predictive Learning Models MH - Respiration, Artificial MH - Risk Assessment/methods PMC - PMC12991431 MID - NIHMS2145014 COIS- Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study was performed in accordance with Declaration of Helsinki. It was approved with waiver of informed consent by the Duke Health Institutional Review Board (Pro00106931). EDAT- 2026/02/17 00:53 MHDA- 2026/10/20 05:30 CRDT- 2026/02/16 23:25 PHST- 2025/03/10 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2025/12/10 00:00 [revised] PHST- 2026/10/20 05:30 [medline] PHST- 2026/02/17 00:53 [pubmed] PHST- 2026/02/16 23:25 [entrez] AID - 10.1038/s41372-026-02576-2 [pii] AID - 10.1038/s41372-026-02576-2 [doi] PST - ppublish SO - J Perinatol. 2026 Oct;46(10):1915-1921. doi: 10.1038/s41372-026-02576-2. Epub 2026 Feb 16. PMID- 41698718 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 2 DP - 2026 Feb 16 TI - Randomised-controlled feasibility study evaluating the REgulate your SItting Time (RESIT) intervention for reducing sitting in individuals with type 2 diabetes: a process evaluation. PG - e101309 LID - 10.1136/bmjopen-2025-101309 [doi] LID - e101309 AB - OBJECTIVES: The REgulate your SItting Time (RESIT) is a tailored intervention targeting reductions and breaks in sitting in adults with type 2 diabetes mellitus (T2DM). A feasibility trial of RESIT had been conducted and the purpose of this paper is to report findings from the process evaluation. DESIGN: A mixed-methods process evaluation within a randomised controlled feasibility trial. SETTING: The study was conducted remotely in the community. PARTICIPANTS: Ambulatory individuals with T2DM aged 18-85 years. INTERVENTION: A tailored intervention comprising an online education session, regular health coaching and technology for self-monitoring behaviour and prompting breaks in sitting. PRIMARY AND SECONDARY OUTCOME MEASURES: Questionnaires (intervention participants n=22 at both 3 and 6 months; control participants n=21 at 3 months, n=29 at 6 months) and interviews (n=30, with n=13 intervention participants, n=12 control participants, n=5 health coaches) to assess perceptions of the intervention components, strategies and barriers for sitting less, the role of the study evaluation measures, and reasons for taking part. RESULTS: The trial operated a largely successful online education element for those in the intervention group (82% completion; >/=76% engagement in individual educational elements). There was good use of self-monitoring and prompt technology (apps and wearables) with 73% of participants reporting using these at 6 months. Health coaching had high engagement and was perceived as enjoyable and useful. Data revealed strategies used for behaviour change (eg, active functional tasks) alongside barriers to change (eg, restrictions at work). There were also potential behavioural influences from the study evaluation measures (eg, activity measures increasing awareness and execution of behaviours) for both intervention and control participants. CONCLUSIONS: A comprehensive process evaluation identified successful intervention elements (ie, online education, health coaching, wearables and smartphone apps) alongside strategies and barriers to behaviour change. These findings can inform future sedentary behaviour interventions for adults with T2DM and a definitive randomised controlled trial evaluating RESIT. TRIAL REGISTRATION NUMBER: ISRCTN14832389. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Biddle, Stuart J H AU - Biddle SJH AD - Centre for Health Research & Manna Institute, University of Southern Queensland, Springfield Central, UK. AD - Faculty of Sport & Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. FAU - Brierley, Marsha L AU - Brierley ML AD - Department of Sport, Health and Exercise Sciences, Brunel University of London, London, UK. AD - Centre for Physical Activity in Health and Disease, College of Health, Medicine and Life Sciences, Brunel University of London, London, UK. FAU - Castle, Ellen AU - Castle E AD - Centre for Physical Activity in Health and Disease, College of Health, Medicine and Life Sciences, Brunel University of London, London, UK. AD - Department of Health Sciences, Brunel University of London, London, UK. FAU - Hunt, Emily R AU - Hunt ER AUID- ORCID: 0000-0003-3454-7453 AD - Department of Sport, Health and Exercise Sciences, Brunel University of London, London, UK. AD - Centre for Physical Activity in Health and Disease, College of Health, Medicine and Life Sciences, Brunel University of London, London, UK. FAU - Chater, Angel AU - Chater A AD - Institute for Sport and Physical Activity Research, University of Bedfordshire, Bedford, UK. AD - Centre for Behaviour Change, University College London, London, England, UK. FAU - Edwardson, Charlotte AU - Edwardson C AD - Leicester Lifestyle and Health Research Group, Diabetes Research Centre, University of Leicester, Leicester, UK. AD - NIHR Leicester Biomedical Research Centre, Leicester General Hospital, Leicester, UK. FAU - Bailey, Daniel AU - Bailey D AUID- ORCID: 0000-0003-3772-630X AD - Department of Sport, Health and Exercise Sciences, Brunel University of London, London, UK daniel.bailey@brunel.ac.uk. AD - Centre for Physical Activity in Health and Disease, College of Health, Medicine and Life Sciences, Brunel University of London, London, UK. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260216 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/therapy MH - Female MH - Middle Aged MH - Feasibility Studies MH - Male MH - Aged MH - Adult MH - *Sitting Position MH - Aged, 80 and over MH - *Sedentary Behavior MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - Digital Health PMC - PMC12911826 OTO - NOTNLM OT - Behavior OT - Diabetes Mellitus, Type 2 OT - Digital Technology OT - Exercise OT - SPORTS MEDICINE COIS- Competing interests: None declared. EDAT- 2026/02/17 00:53 MHDA- 2026/02/17 00:54 PMCR- 2026/02/16 CRDT- 2026/02/16 20:43 PHST- 2026/02/17 00:54 [medline] PHST- 2026/02/17 00:53 [pubmed] PHST- 2026/02/16 20:43 [entrez] PHST- 2026/02/16 00:00 [pmc-release] AID - bmjopen-2025-101309 [pii] AID - 10.1136/bmjopen-2025-101309 [doi] PST - epublish SO - BMJ Open. 2026 Feb 16;16(2):e101309. doi: 10.1136/bmjopen-2025-101309. PMID- 41698348 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260813 IS - 1525-1470 (Electronic) IS - 0736-8046 (Print) IS - 0736-8046 (Linking) VI - 43 IP - 3 DP - 2026 May-Jun TI - Diagnosis and Management of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Pediatric Patients: A Systematic Review of Clinical Guidelines and Consensus Statements. PG - 579-589 LID - 10.1111/pde.70149 [doi] AB - Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are rare, life-threatening mucocutaneous reactions. Pediatric mortality is lower than in adults, but children face higher risks of recurrence and long-term sequelae. Despite disease severity, pediatric-specific guidelines remain scarce and often extrapolated from adult populations. We systematically reviewed and appraised national and international clinical practice guidelines and consensus statements on pediatric SJS/TEN, focusing on supportive care, pharmacologic interventions, mucosal management, and long-term follow-up. A systematic search of MEDLINE, Embase, PubMed, CENTRAL, Scopus, and CINAHL (January 2000-April 2025) identified national and international guidelines. For feasibility, we restricted full appraisal to documents published in English or French. Eligible documents provided explicit recommendations for patients < 18 years. Two reviewers independently extracted data and assessed quality using the AGREE II instrument. Of 144 records screened, 10 guidelines met inclusion criteria; 60% were published within the last 5 years, and 50% were consensus-based without systematic evidence synthesis. Most (90%) endorsed supportive measures such as wound care, nutritional support, and fluid resuscitation. Recommendations for pharmacologic therapy varied considerably: intravenous immunoglobulin (50%), systemic corticosteroids (40%), and cyclosporine (40%), with limited pediatric dosing guidance. Only one guideline mentioned biologics. Multidisciplinary care was recommended in 90%, yet long-term follow-up for sequelae appeared in only 50%. AGREE II appraisal showed high clarity of presentation but consistently low applicability; only the British Association of Dermatologists guideline achieved high quality across all domains. Current pediatric SJS/TEN guidelines display heterogeneity in scope and rigor. While supportive care is emphasized, pharmacologic and long-term management guidance remains inconsistent. Standardized, evidence-based, pediatric-specific guidelines are urgently needed. CI - (c) 2026 The Author(s). Pediatric Dermatology published by Wiley Periodicals LLC. FAU - Creighton, Rachel AU - Creighton R AUID- ORCID: 0009-0006-4679-9593 AD - Faculty of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada. FAU - Gupta, Sana AU - Gupta S AD - Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada. FAU - Langille, Courtney AU - Langille C AD - Faculty of Medicine, Division of Dermatology, Dalhousie University, Halifax, Nova Scotia, Canada. FAU - Sutherland, Ashley AU - Sutherland A AD - Faculty of Medicine, Division of Dermatology, Dalhousie University, Halifax, Nova Scotia, Canada. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260216 PL - United States TA - Pediatr Dermatol JT - Pediatric dermatology JID - 8406799 SB - IM MH - Child MH - Humans MH - Consensus MH - *Consensus Statements as Topic MH - *Practice Guidelines as Topic MH - *Stevens-Johnson Syndrome/diagnosis/therapy PMC - PMC13206584 OTO - NOTNLM OT - SJS/TEN OT - clinical practice guideline OT - consensus statement OT - management OT - pediatrics OT - systematic review COIS- The authors declare no conflicts of interest. EDAT- 2026/02/17 00:53 MHDA- 2026/05/24 18:32 PMCR- 2026/05/26 CRDT- 2026/02/16 18:25 PHST- 2025/11/26 00:00 [revised] PHST- 2025/09/05 00:00 [received] PHST- 2026/01/23 00:00 [accepted] PHST- 2026/05/24 18:32 [medline] PHST- 2026/02/17 00:53 [pubmed] PHST- 2026/02/16 18:25 [entrez] PHST- 2026/05/26 00:00 [pmc-release] AID - PDE70149 [pii] AID - 10.1111/pde.70149 [doi] PST - ppublish SO - Pediatr Dermatol. 2026 May-Jun;43(3):579-589. doi: 10.1111/pde.70149. Epub 2026 Feb 16. PMID- 41698239 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2191-0251 (Electronic) IS - 0334-018X (Linking) VI - 39 IP - 3 DP - 2026 Mar 26 TI - Evaluation of adrenomedullin levels in adolescents with Hashimoto's thyroiditis: association with clinical and laboratory findings. PG - 265-272 LID - 10.1515/jpem-2025-0515 [doi] AB - OBJECTIVES: Hashimoto thyroiditis (HT) is an autoimmune disorder that may be associated with systemic inflammation. Adrenomedullin (ADM) is a peptide known to be elevated in inflammatory conditions, but its role in pediatric HT has not been extensively studied. To investigate serum ADM levels and their relationship with clinical and laboratory parameters in adolescents with HT. METHODS: This cross-sectional study included 46 adolescents with HT and 41 age-, sex-, and BMI-matched healthy controls. Serum ADM, thyroid function tests, anti-thyroid antibodies, IL-6, and CRP levels were measured. Clinical features including goiter and symptom status were recorded. Correlation and multivariate logistic regression analyses were performed to evaluate associations and predictive factors. RESULTS: ADM levels were significantly higher in the HT group than in controls (p=0.016). TSH, anti-TPO, anti-TG, and IL-6 levels were also elevated, while free T4 and CRP did not differ significantly. ADM correlated with TSH and thyroid functional status but not with IL-6 or CRP. Goiter was present in 28 % of patients, with all patients with goiter showing elevated ADM. Multivariate analysis identified TSH, free T4, and ADM as significant predictors of HT. Receiver operating characteristic analysis showed moderate diagnostic performance for ADM (AUC=0.651). CONCLUSIONS: Serum adrenomedullin levels were elevated in adolescents with Hashimoto thyroiditis compared with matched controls and were associated with thyroid dysfunction and local inflammatory activity. Although ADM showed only moderate diagnostic performance, this exploratory first study in pediatric HT suggests a potential role in disease pathophysiology and warrants confirmation in larger prospective cohort studies. CI - (c) 2026 Walter de Gruyter GmbH, Berlin/Boston. FAU - Cambaz Kurt, Nevin AU - Cambaz Kurt N AUID- ORCID: 0000-0003-4066-1834 AD - Department of Pediatrics, University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkiye. FAU - Kocabey Sutcu, Zumrut AU - Kocabey Sutcu Z AUID- ORCID: 0000-0001-7335-1272 AD - Department of Pediatric Endocrinology, University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkiye. FAU - Sener, Gulsen AU - Sener G AUID- ORCID: 0000-0002-2006-2175 AD - Department of Biochemistry, University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkiye. FAU - Onal, Hasan AU - Onal H AUID- ORCID: 0000-0001-9676-7086 AD - Department of Pediatric Endocrinology, University of Health Sciences, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkiye. LA - eng PT - Journal Article DEP - 20260210 PL - Germany TA - J Pediatr Endocrinol Metab JT - Journal of pediatric endocrinology & metabolism : JPEM JID - 9508900 RN - 148498-78-6 (Adrenomedullin) RN - 0 (Biomarkers) RN - 0 (ADM protein, human) RN - 9002-71-5 (Thyrotropin) RN - 0 (Interleukin-6) SB - IM MH - Humans MH - *Adrenomedullin/blood MH - Female MH - Adolescent MH - *Hashimoto Disease/blood/diagnosis MH - Male MH - Cross-Sectional Studies MH - *Biomarkers/blood MH - Case-Control Studies MH - Thyroid Function Tests MH - Prognosis MH - Follow-Up Studies MH - Thyrotropin/blood MH - Child MH - Interleukin-6/blood OTO - NOTNLM OT - Hashimoto thyroiditis OT - adolescents OT - adrenomedullin OT - autoimmune thyroiditis OT - inflammation EDAT- 2026/02/16 18:34 MHDA- 2026/03/09 07:42 CRDT- 2026/02/16 17:32 PHST- 2025/09/10 00:00 [received] PHST- 2026/01/12 00:00 [accepted] PHST- 2026/03/09 07:42 [medline] PHST- 2026/02/16 18:34 [pubmed] PHST- 2026/02/16 17:32 [entrez] AID - jpem-2025-0515 [pii] AID - 10.1515/jpem-2025-0515 [doi] PST - epublish SO - J Pediatr Endocrinol Metab. 2026 Feb 10;39(3):265-272. doi: 10.1515/jpem-2025-0515. Print 2026 Mar 26. PMID- 41697894 OWN - NLM STAT- Publisher LR - 20260813 IS - 1663-2826 (Electronic) IS - 1663-2818 (Print) IS - 1663-2818 (Linking) DP - 2026 Feb 16 TI - Testing Multiple Delivery Methods of the Virtual Exercise Games for Youth with T1D Peer Intervention: Protocol Development and Feasibility. PG - 1-18 LID - 10.1159/000550880 [doi] AB - INTRODUCTION: Adolescents with type 1 diabetes (T1D) face barriers to moderate-to-vigorous physical activity (MVPA) such as uncertainty with self-management, limited access to supportive environments, and stigma related to living with diabetes. Opportunities for peer activities with T1D role model support are limited. To address this need, we tested iterative refinements of pilot Virtual Exercise Games for Youth with T1D (ExerT1D) for feasibility and acceptability. METHODS: The program included 6 versions: study 1 (1.1-1.4) included an active video game, and study 2 (2.1-2.2) included a virtual reality (VR) active video game. All versions included T1D exercise management education by clinicians and goal-setting guided by young adult coaches with T1D. RESULTS: Seventeen adolescents (median age 15.4 [IQR 14.6-16.4] years, 7 non-Hispanic white, 8 male, median HbA1c 8.1% [IQR 7.4%-11.1%]) were enrolled. Participants rated the program, comfort, clinicians, coaches, and group cohesion high/very high. Motivation for the video game was high. Building T1D and MVPA self-management skills was rated excellent at most sessions, as were peer interactions and enriched communication after adding immersive VR in study 2. Transitions between VR apps caused delays of 19 +/- 6 min per 60 min-90 min session. Compared to baseline, HbA1c or glucose management indicator decreased over time in an exploratory analysis (d = -1.12, 90% CI: [-1.78, -0.48]). CONCLUSIONS: In a small cohort, the ExerT1D program facilitated a supportive environment for engaging diverse youth with T1D in an MVPA program led by T1D coaches. Larger studies are needed to assess the intervention's impact on engagement with physical activity, glycemic outcomes, and quality of life. CI - (c) 2026 S. Karger AG, Basel. FAU - Ash, Garrett I AU - Ash GI AD - Department of Internal Medicine and Department of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, Connecticut, USA, garrett.ash@yale.edu. AD - Center for Pain, Research, Informatics, Medical Comorbidities and Education Center (PRIME), VA Connecticut Healthcare System, West Haven, Connecticut, USA, garrett.ash@yale.edu. FAU - Nam, Soohyun AU - Nam S AD - Yale School of Nursing, Orange, Connecticut, USA. FAU - Mak, Selene S AU - Mak SS AD - Center for the Study of Healthcare Innovation, Implementation and Policy (CSHIIP), VA Greater Los Angeles Healthcare System, Los Angeles, California, USA. FAU - Stults-Kolehmainen, Matthew AU - Stults-Kolehmainen M AD - Center for Weight Management, Yale New Haven Hospital, North Haven, Connecticut, USA. AD - Department of Biobehavioral Sciences, Teachers College - Columbia University, New York, New York, USA. FAU - Haughton, Adrian D AU - Haughton AD AD - Department of Internal Medicine and Department of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, Connecticut, USA. AD - Department of Health and Movement Sciences Programs, Southern Connecticut State University, New Haven, Connecticut, USA. FAU - Turek, Carolyn AU - Turek C AD - Child Study Center, Yale School of Medicine, New Haven, Connecticut, USA. AD - Pritzker Department of Psychiatry and Behavioral Health, Ann and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA. FAU - Baker, Julien S AU - Baker JS AD - Centre for Health and Exercise Science Research, Population Health and Medical Informatics, Hong Kong Baptist University, Hong Kong, Hong Kong, China. FAU - Hieftje, Kimberly AU - Hieftje K AD - Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA. FAU - Marks, Asher AU - Marks A AD - Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA. FAU - Chmielewski, Annette AU - Chmielewski A AD - Department of Internal Medicine and Department of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, Connecticut, USA. FAU - Shelver, Michael AU - Shelver M AD - Department of Internal Medicine and Department of Biomedical Informatics and Data Science, Yale School of Medicine, New Haven, Connecticut, USA. FAU - Considine, Elizabeth G AU - Considine EG AD - Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA. FAU - Lukasik, James L AU - Lukasik JL AD - Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA. FAU - Weinzimer, Stuart A AU - Weinzimer SA AD - Yale School of Nursing, Orange, Connecticut, USA. AD - Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA. FAU - Nally, Laura M AU - Nally LM AD - Department of Pediatrics, Yale School of Medicine, New Haven, Connecticut, USA, laura.nally@yale.edu. LA - eng GR - 852679/AHA/American Heart Association-American Stroke Association/United States GR - K01 DK129441/DK/NIDDK NIH HHS/United States GR - K23 DK128560/DK/NIDDK NIH HHS/United States GR - P30 DK045735/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20260216 PL - Switzerland TA - Horm Res Paediatr JT - Hormone research in paediatrics JID - 101525157 SB - IM UOF - medRxiv. 2025 May 28:2024.07.03.24309308. doi: 10.1101/2024.07.03.24309308. PMID: 39006443 PMC - PMC12971191 MID - NIHMS2149592 OTO - NOTNLM OT - Diabetes OT - Peer support OT - Physical activity OT - Type 1 OT - Video games COIS- G.I.A. has in the last 3 years received grant support (to his institution) from the Patterson Trust, American Heart Association, National Institutes of Health, and Veterans Health Administration. He has also received professional services from Calm.com (nominal fee), Glucosezone (full fee), and Labfront (full fee), on projects separate from the present study. He is also a scientific advisor for WellModeled LLC and co-founder of the Livewell patent application. S.N. receives grant support (to her institution) from the National Institutes of Health. C.T. is a consultant for Calm.com. M.S. is employed as a senior product manager by Abbott Laboratories and receives restricted stock units. The Yale Children's Diabetes Center receives free CGM supplies through the Abbott Laboratories clinical sample program, which are distributed to patients including some who participated in this study. L.M.N. received grant support (to her institution) for research from the National Institutes of Health and Medtronic Diabetes. She has been on a pediatric advisory board for Insulet and is a consultant for Medtronic, WebMD, Sequel Med Tech, and Calm.com. The authors attest that the Patterson Trust, American Heart Association, National Institutes of Health, Veterans Health Administration, Calm.com, Glucosezone, Labfront, Abbott Laboratories, Dexcom, Zealand Pharma, Medtronic, and WebMD had no influence on the design of this study or its outcomes. The authors conducted the research outside of their responsibilities and affiliations with these entities. EDAT- 2026/02/16 18:34 MHDA- 2026/02/16 18:34 PMCR- 2026/03/09 CRDT- 2026/02/16 13:23 PHST- 2025/07/04 00:00 [received] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/02/16 18:34 [pubmed] PHST- 2026/02/16 18:34 [medline] PHST- 2026/02/16 13:23 [entrez] PHST- 2026/03/09 00:00 [pmc-release] AID - 000550880 [pii] AID - 10.1159/000550880 [doi] PST - aheadofprint SO - Horm Res Paediatr. 2026 Feb 16:1-18. doi: 10.1159/000550880. PMID- 41697858 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260708 IS - 1460-2210 (Electronic) IS - 0141-5387 (Linking) VI - 48 IP - 1 DP - 2025 Dec 16 TI - Postoperative craniocervical change after bilateral sagittal split ramus osteotomy in Classes II and III: predictive role of mandibular rotation and tongue-hyoid coupling. LID - cjaf111 [pii] LID - 10.1093/ejo/cjaf111 [doi] AB - OBJECTIVE: This study aims to evaluate postoperative craniocervical changes after bilateral sagittal split ramus osteotomy (BSSRO), to test mandibular translation and rotation as predictors, and to explore their coupling with tongue and hyoid adaptations. MATERIALS AND METHODS: A total of 210 patients (88 males, 122 females; 18-58 years) were equally divided into skeletal Classes I-III. Cephalograms in natural head posture were obtained pre- and postoperatively. Craniocervical change (DeltaNSL/OPT) was the primary outcome. Mandibular translation (DeltaGo-Me) and rotation (DeltaFH-MP) served as predictors, with tongue and hyoid variables as secondary outcomes. Reliability was assessed using intraclass correlation coefficients (ICCs). Statistical analyses included analysis of variance (ANOVA), correlation, and multivariable regression. RESULTS: Measurement reproducibility was excellent (ICC > 0.92). Mandibular advancement (Class II) and setback (Class III) produced class-specific changes in DeltaGo-Me and DeltaFH-MP. Postoperatively, Class II showed cervical flexion (-3.09 degrees  +/- 7.12 degrees ) whereas Class III showed cervical extension (+2.92 degrees  +/- 5.48 degrees , P < .001). DeltaNSL/OPT correlated with DeltaFH-MP (r = 0.25, P = .002) and DeltaGo-Me (r = 0.17, P = .017), though only DeltaFH-MP remained significant in regression (beta approximately 0.47 degrees per 1 degrees rotation). DeltaNSL/OPT was most strongly correlated with DeltaSNH (r = 0.62, P < .001), indicating coordinated craniocervical-hyoid adaptation. Tongue showed modest lengthening, flattening, and anterior shift across both advancement and setback groups. CONCLUSIONS: Cervical extension after BSSRO is primarily driven by mandibular rotation rather than translation, underscoring the clinical importance of incorporating rotational vectors into surgical planning. Coupled tongue-hyoid adaptations reflect early neuromuscular compensation, with potential implications for long-term stability and functional outcomes. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the European Orthodontic Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Kaboosaya, Boosana AU - Kaboosaya B AUID- ORCID: 0000-0002-0511-4678 AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Wangmai, Pathum Wan, Bangkok 10330, Thailand. FAU - Wangpiriyapanish, Nattavee AU - Wangpiriyapanish N AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Wangmai, Pathum Wan, Bangkok 10330, Thailand. FAU - Damrongsirirat, Napat AU - Damrongsirirat N AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Wangmai, Pathum Wan, Bangkok 10330, Thailand. FAU - Pimkhaokham, Atiphan AU - Pimkhaokham A AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Wangmai, Pathum Wan, Bangkok 10330, Thailand. LA - eng PT - Journal Article PL - England TA - Eur J Orthod JT - European journal of orthodontics JID - 7909010 SB - IM MH - Humans MH - Female MH - *Hyoid Bone/physiology MH - *Osteotomy, Sagittal Split Ramus/methods MH - Cephalometry/methods MH - Rotation MH - *Mandible/pathology/surgery MH - *Tongue/physiology MH - Adult MH - Adolescent MH - *Malocclusion, Angle Class III/surgery MH - *Malocclusion, Angle Class II/surgery MH - Young Adult MH - Male MH - Middle Aged MH - Mandibular Advancement/methods MH - Cervical Vertebrae MH - Reproducibility of Results MH - Adaptation, Physiological OTO - NOTNLM OT - BSSRO OT - NSL/OPT OT - cephalometry OT - craniocervical posture OT - hyoid OT - mandibular rotation OT - tongue COIS- Conflicts of interest: All authors have no conflict of interest or personal and financial relationships with other people or organizations in this study. EDAT- 2026/02/16 18:34 MHDA- 2026/02/16 18:35 CRDT- 2026/02/16 12:53 PHST- 2026/02/16 18:35 [medline] PHST- 2026/02/16 18:34 [pubmed] PHST- 2026/02/16 12:53 [entrez] AID - 8487656 [pii] AID - 10.1093/ejo/cjaf111 [doi] PST - ppublish SO - Eur J Orthod. 2025 Dec 16;48(1):cjaf111. doi: 10.1093/ejo/cjaf111. PMID- 41697175 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260730 IS - 1879-1972 (Electronic) IS - 1054-139X (Linking) VI - 78 IP - 6 DP - 2026 Jun TI - Toward Earlier Bedtimes: Randomized Trial of Multi-Method Interventions in a Community Cohort of Adolescents. PG - 854-864 LID - S1054-139X(25)00817-1 [pii] LID - 10.1016/j.jadohealth.2025.12.247 [doi] AB - PURPOSE: Many adolescents develop very late circadian rhythms, indicating delayed sleep phase. Interventions are sparse, and the stability of any improvements is rarely reported. To evaluate how late sleep patterns can be improved, we performed a randomized control trial among adolescents. Overall, 4-6-week intervention modes included bright light therapy (BLT), personalized sleep coaching, or their combination (BLSC), and an active control group receiving information. METHODS: We measured the sleep and circadian patterns of 288 adolescents (17 years) born in years 1999-2000. A sub-sample (n = 176) that weighted on late sleep rhythms participated in the randomized control trial. Sleep, circadian temperature patterns, depressive symptoms, anxiety, and sleep hygiene were measured at baseline (T1) after the intervention (T2) and after 1 year (T3) with GeneActiv Original actigraphy, ibutton 1922L thermologgers, and validated questionnaires. RESULTS: Participants in the SC group significantly increased their sleep duration compared to the control group, 23 minutes from T1 to T2 and 33 minutes from T1 to T3 (p < .03). They also improved their sleep hygiene from T1 to T2 (p = .019), but this did not persist to T3. Other groups did not improve their sleep patterns. DISCUSSION: Although personalized sleep coaching resulted in persistently longer sleep, none of the interventions were successful in overcoming late sleep rhythms among an adolescent sample derived from the population register. Delayed sleep phase is a persistent condition with biological components, and a 4-week intervention is presumably too short for changing sleep behavior and rhythms. Clinical Trials number 1287174/NCT02964598. CI - Copyright (c) 2025 Society for Adolescent Health and Medicine. Published by Elsevier Inc. All rights reserved. FAU - Kuula, Liisa AU - Kuula L AD - Faculty of Medicine, SleepWell Research Program, University of Helsinki, Helsinki, Finland; Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland. Electronic address: liisa.kuula@helsinki.fi. FAU - Pesonen, Anu-Katriina AU - Pesonen AK AD - Faculty of Medicine, SleepWell Research Program, University of Helsinki, Helsinki, Finland. LA - eng SI - ClinicalTrials.gov/NCT02964598 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260216 PL - United States TA - J Adolesc Health JT - The Journal of adolescent health : official publication of the Society for Adolescent Medicine JID - 9102136 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Sleep Duration MH - *Circadian Rhythm/physiology MH - *Sleep/physiology MH - *Phototherapy/methods MH - Actigraphy MH - Sleep Hygiene MH - Surveys and Questionnaires EDAT- 2026/02/16 12:30 MHDA- 2026/05/13 00:29 CRDT- 2026/02/16 10:28 PHST- 2025/04/25 00:00 [received] PHST- 2025/11/28 00:00 [revised] PHST- 2025/12/01 00:00 [accepted] PHST- 2026/05/13 00:29 [medline] PHST- 2026/02/16 12:30 [pubmed] PHST- 2026/02/16 10:28 [entrez] AID - S1054-139X(25)00817-1 [pii] AID - 10.1016/j.jadohealth.2025.12.247 [doi] PST - ppublish SO - J Adolesc Health. 2026 Jun;78(6):854-864. doi: 10.1016/j.jadohealth.2025.12.247. Epub 2026 Feb 16. PMID- 41696919 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260902 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 37 IP - 7-8 DP - 2026 Jul-Aug 01 TI - Frontal Orientation in Orthognathic Surgery and Determination of a "Surgical Vertical Target Line". PG - 1915-1920 LID - 10.1097/SCS.0000000000012530 [doi] AB - This study explores the use of the bipupillary line (BPL) as a true horizontal line (THL) for frontal orientation in orthognathic surgery (OGS), addressing the need for a reliable vertical reference, or "surgical vertical target line" (SVTL), in patients with dentofacial deformities. In a retrospective analysis of 50 consecutive patients (25 male, 25 female; mean age 27 y, range 18-52) at a specialized center in Buenos Aires, Argentina, we standardized frontal orientation using the BPL and determined the SVTL based on its alignment with anatomic midline points, including the intercanthal point (Ic), subnasal point (Sn), philtrum (Ph), upper dental midline (UDM), and soft tissue pogonion (SPo). The SVTL was most frequently aligned with the subnasal point (86%), compared with 44% for the intercanthal point and 42% for the philtrum. The selection of the SVTL was individualized for each patient to best suit the patient's face. Notably, parallelism between the BPL and bicommissural line (BCL) was observed in only 38% of cases, with divergence in 62%. Patients with a tilted BCL exhibited a significantly higher prevalence of clinical mandibular lateral deviation (CMLD) (90.3% versus 36.8%, P <0.01). Discrepancies between the SVTL and bony pogonion (BPo) on CBCT revealed that deviations >/=2 mm were clinically detectable in all cases, while those <2 mm were imperceptible in 83.3% of cases ( P <0.01). On the basis of these findings, we propose a classification for mandibular lateral deviation: subclinical (<2 mm), slight (2-<4 mm), moderate (4-<8 mm), and severe (>/=8 mm). The BPL-based frontal orientation and SVTL protocol offer a simple, reproducible approach that enhances diagnostic accuracy and supports precise surgical planning in OGS. CI - Copyright (c) 2026 by Mutaz B. Habal, MD. FAU - Astigueta, Jose M AU - Astigueta JM AD - Centro Especializando en Ortodoncia y Cirugia (CEOC), Autonomous City of Buenos Aires (CABA), Argentina. FAU - Llensa, Leandro AU - Llensa L FAU - Ruiz, Damian AU - Ruiz D FAU - Grosso, Maria AU - Grosso M FAU - Giannunzio, Graciela A AU - Giannunzio GA LA - eng PT - Journal Article DEP - 20260216 PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 SB - IM MH - Humans MH - Female MH - Retrospective Studies MH - *Orthognathic Surgical Procedures/methods MH - Adult MH - Adolescent MH - Male MH - Middle Aged MH - Young Adult MH - Anatomic Landmarks MH - Cephalometry MH - Argentina MH - *Dentofacial Deformities/surgery/diagnostic imaging OTO - NOTNLM OT - Bipupillary line OT - frontal orientation OT - mandibular lateral deviation OT - orthognathic surgery OT - surgical vertical target line COIS- The authors report no conflicts of interest. EDAT- 2026/02/16 12:30 MHDA- 2026/07/10 18:46 CRDT- 2026/02/16 08:03 PHST- 2025/10/07 00:00 [received] PHST- 2026/01/16 00:00 [accepted] PHST- 2026/07/10 18:46 [medline] PHST- 2026/02/16 12:30 [pubmed] PHST- 2026/02/16 08:03 [entrez] AID - 00001665-990000000-03750 [pii] AID - 10.1097/SCS.0000000000012530 [doi] PST - ppublish SO - J Craniofac Surg. 2026 Jul-Aug 01;37(7-8):1915-1920. doi: 10.1097/SCS.0000000000012530. Epub 2026 Feb 16. PMID- 41696693 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260216 LR - 20260218 IS - 2673-253X (Electronic) IS - 2673-253X (Linking) VI - 7 DP - 2025 TI - Assessment and analysis of content and quality of children's influenza vaccine information on BiliBili, Douyin, and Xiaohongshu. PG - 1591347 LID - 10.3389/fdgth.2025.1591347 [doi] LID - 1591347 AB - BACKGROUND: Each year, influenza vaccines play a vital role in preventing millions of illnesses and reducing flu-related healthcare visits. Short video platforms (including Douyin, BiliBili, and Xiaohongshu) are powerful vehicles for information sharing and are saturated with videos about children's influenza vaccines. Nevertheless, the quality of these videos remains undetermined. PURPOSE AND OBJECTIVES: This study aims to assess the quality and reliability of videos addressing children's influenza vaccines on three short video platforms: Douyin, BiliBili, and Xiaohongshu. METHODS: Using a cross-sectional survey design, this study examined three short video platforms (all mainland China versions). In February 2025, the research team searched Douyin, BiliBili, and Xiaohongshu for the keyword "children's influenza vaccine," selecting 300 videos (100 per platform) for analysis. We extracted basic video information, coded the content, and identified each video's source. Two independent reviewers then evaluated video quality using the American Medical Association (JAMA) benchmarks, the modified DISCERN (mDISCERN) criteria, and the Global Quality Score (GQS). RESULTS: A detailed analysis of 300 videos revealed that on Douyin and Xiaohongshu, most videos were created by professionals and lay users, whereas on BiliBili, most were uploaded by non-profit organizations. Douyin stood out in user engagement, as its videos received significantly higher numbers of likes, comments, favorites, and shares than those on BiliBili and Xiaohongshu (p < 0.001). Furthermore, we observed a strong positive correlation between overall quality scores and comment volume (Spearman rho = 0.90, p < 0.001); correlations with likes (rho = 0.77) and favorites (rho = 0.73) were moderate but still significant (p < 0.001). Score differences also emerged based on source type (p < 0.001). Videos published by health professionals were rated highest, ordinary-user videos received lower ratings, and those from news agencies and non-profit organizations fell in between. In terms of quality ratings, there were no statistically significant differences among the GQS, JAMA, and mDISCERN scoring systems. CONCLUSION: These findings suggest that Douyin, BiliBili, and Xiaohongshu offer moderately rated scientific content regarding children's influenza vaccines. Viewers should exercise caution when watching related videos on these platforms. Moving forward, both the platforms and content creators must strive to improve video quality and reliability to boost vaccination rates. These efforts have important implications for clinical practice, offering new perspectives for health education interventions and better promoting public awareness of vaccination's significance-ultimately contributing positively to public health. CI - (c) 2026 Jiang, Sun and Chen. FAU - Jiang, Shanwei AU - Jiang S AD - Yantaishan Hospital, East Campus, Yantai, China. FAU - Sun, Hui AU - Sun H AD - Yantaishan Hospital, East Campus, Yantai, China. FAU - Chen, Xiaowei AU - Chen X AD - Yantaishan Hospital, East Campus, Yantai, China. LA - eng PT - Journal Article DEP - 20260130 PL - Switzerland TA - Front Digit Health JT - Frontiers in digital health JID - 101771889 PMC - PMC12902773 OTO - NOTNLM OT - child OT - influenza vaccine OT - information quality OT - short videos OT - social media COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/16 12:30 MHDA- 2026/02/16 12:31 PMCR- 2026/01/30 CRDT- 2026/02/16 06:58 PHST- 2025/03/11 00:00 [received] PHST- 2025/11/01 00:00 [revised] PHST- 2025/11/20 00:00 [accepted] PHST- 2026/02/16 12:31 [medline] PHST- 2026/02/16 12:30 [pubmed] PHST- 2026/02/16 06:58 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - 10.3389/fdgth.2025.1591347 [doi] PST - epublish SO - Front Digit Health. 2026 Jan 30;7:1591347. doi: 10.3389/fdgth.2025.1591347. eCollection 2025. PMID- 41695454 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260216 LR - 20260218 IS - 2673-5059 (Electronic) IS - 2673-5059 (Linking) VI - 7 DP - 2026 TI - Validation and factorial invariance of the breastfeeding self-efficacy scale-short form in Ecuadorian mothers. PG - 1707796 LID - 10.3389/fgwh.2026.1707796 [doi] LID - 1707796 AB - BACKGROUND: Breastfeeding is one of the most cost-effective public health interventions to improve child survival and development. A key determinant of breastfeeding initiation and continuation is maternal self-efficacy, defined as a mother's confidence in her ability to breastfeed. The Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF) is one of the most widely used instruments internationally to assess this construct. However, no validation studies have been conducted in Ecuador, and evidence from Latin America remains limited, particularly regarding advanced psychometric analyses. OBJECTIVE: To validate the Spanish version of the BSES-SF in Ecuadorian mothers with previous breastfeeding experience, examining its factorial structure, factorial invariance, reliability, and convergent validity. METHODS: An instrumental psychometric study was conducted with 325 mothers recruited from public and private health centers in Loja, Ecuador, who had breastfeeding experience during the child's first two years of life. Confirmatory factor analysis (CFA) was used to compare competing factorial models, and multi-group CFA tested factorial invariance across maternal age groups. Reliability was assessed using Cronbach's alpha and McDonald's omega. Convergent validity was examined through correlations with psychological capital (PCQ-12) and positive mental health (PMH-9). RESULTS: A second-order four-factor model showed the best fit to the data (chi(2)/df = 1.39; CFI = 0.998; TLI = 0.997; SRMR = 0.043; RMSEA = 0.035) and demonstrated full factorial invariance across age groups. Convergent validity was generally adequate, although one dimension showed average variance extracted values below the recommended threshold. The scale showed excellent overall reliability (alpha = 0.915; omega = 0.929) and significant positive correlations with psychological capital and positive mental health. CONCLUSION: The Spanish version of the BSES-SF is a valid and reliable instrument for assessing breastfeeding self-efficacy in Ecuadorian mothers. Clinically, it supports early identification of women at risk of low breastfeeding self-efficacy, facilitating timely and targeted breastfeeding support. From a public health and policy perspective, this psychometrically robust and culturally adapted instrument can inform breastfeeding promotion programs, equity-focused maternal health interventions, and monitoring of nutrition and health-related Sustainable Development Goals. CI - (c) 2026 Rojas-Rodriguez, Lopez-Guerra, Trelles-Guarnizo and Rodriguez-Romero. FAU - Rojas-Rodriguez, Ana Lizette AU - Rojas-Rodriguez AL AD - Department of Health Sciences, Universidad Tecnica Particular de Loja, Loja, Ecuador. FAU - Lopez-Guerra, Victor AU - Lopez-Guerra V AD - Department of Psychology, Universidad Tecnica Particular de Loja, Loja, Ecuador. FAU - Trelles-Guarnizo, Cristian AU - Trelles-Guarnizo C AD - Department of Health Sciences, Universidad Tecnica Particular de Loja, Loja, Ecuador. FAU - Rodriguez-Romero, Paulo AU - Rodriguez-Romero P AD - Department of Health Sciences, Universidad Tecnica Particular de Loja, Loja, Ecuador. LA - eng PT - Journal Article DEP - 20260130 PL - Switzerland TA - Front Glob Womens Health JT - Frontiers in global women's health JID - 101776281 PMC - PMC12901464 OTO - NOTNLM OT - Ecuador OT - breastfeeding self-efficacy OT - factorial invariance OT - maternal breastfeeding OT - mothers OT - psychometric analysis OT - scale COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/16 12:30 MHDA- 2026/02/16 12:31 PMCR- 2026/01/30 CRDT- 2026/02/16 06:49 PHST- 2025/10/07 00:00 [received] PHST- 2025/12/22 00:00 [revised] PHST- 2026/01/13 00:00 [accepted] PHST- 2026/02/16 12:31 [medline] PHST- 2026/02/16 12:30 [pubmed] PHST- 2026/02/16 06:49 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - 10.3389/fgwh.2026.1707796 [doi] PST - epublish SO - Front Glob Womens Health. 2026 Jan 30;7:1707796. doi: 10.3389/fgwh.2026.1707796. eCollection 2026. PMID- 41694709 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260216 LR - 20260218 IS - 1745-0179 (Print) IS - 1745-0179 (Electronic) IS - 1745-0179 (Linking) VI - 21 DP - 2025 TI - Objective Assessment of Attention Deficit Hyperactivity Disorder with QbMobile: A Smartphone Application for Clinical Use. PG - e17450179444324 LID - 10.2174/0117450179444324251118134538 [doi] LID - e17450179444324 AB - INTRODUCTION: Digital mental health interventions such as web or mobile applications have become more prominent in the last years to improve the clinical assessment and workflow in mental health disorders while also being potentially more accessible than laptops. QbMobile is a software application that provides objective assessments of hyperactivity, impulsivity, and inattention to aid in the clinical evaluation of attention deficit hyperactivity disorder (ADHD). The purpose was to examine whether QbMobile could objectively quantify symptoms and reveal significant clinical differences between an ADHD population and a normative population. METHODS: Data were acquired from two low-intervention/observational studies (conducted in Europe and US), involving participants aged 6 to 60 years. The application (QbMobile) was configured on the smartphone (iPhone) with embedded instructions to ensure a consistent experience. Participants were seated at a desk in a stabilized chair and instructed to hold the smartphone with both hands and to tap the screen whenever an infrequent target stimulus appeared, while withholding a response to non-target stimuli. Concurrently, to measure activity, the camera of the smartphone captured the physical activity of the participant as well as the movements from holding the device. Approximately 20% of the complete dataset for each study was combined as a pooled dataset for a model validation of output parameters from QbMobile. A Total Score between 0 and 100 was calculated, where lower scores indicate a lower likelihood of ADHD symptoms and higher scores indicate a higher likelihood. RESULTS: The ADHD cohort (n=63) demonstrated a higher mean Total Score of 83.0 (Standard deviation=17.5) compared to 48.9 (Standard deviation=18.8) in the normative population (n=354), a difference that was statistically significant (p<0.001). Significant domain-specific differences in SD-scores (movement pattern, activity, impulsivity, inattention) were identified between the ADHD cohort and the normative comparison group (p<0.001). A sensitivity of 0.86 and specificity of 0.75 were seen overall, though a low specificity was found in children, which was likely due to a smaller sample size and high activity levels in younger children in general. DISCUSSION: This investigation demonstrates that QbMobile can generate objective symptom measurements that distinguish clinically relevant differences between individuals with ADHD and a normative population. A smartphone application of quantified behavioral psychometric testing of the core symptoms could streamline a faster diagnostic evaluation and treatment titration in the ADHD clinical workflow. The authors are employed by the manufacturer of QbMobile, which is discussed in this manuscript. This affiliation is disclosed to ensure transparency and does not affect the objectivity or scientific integrity of the work presented. CONCLUSION: QbMobile demonstrated the ability to differentiate between ADHD and normative cohorts, indicating its potential as an accessible and objective tool for clinical assessment and treatment evaluation. Future studies should be conducted to further validate the effectiveness of QbMobile as an aid tool in the clinical assessment of ADHD and further explore its use in various populations. CI - (c) 2025 The Author(s). Published by Bentham Open. FAU - Gustafsson, Urban AU - Gustafsson U AUID- ORCID: 0000-0002-4571-8062 AD - Qbtech AB, Medical Department, Cardellgatan 1, 11436 Stockholm, Sweden. FAU - Larsson, Simon AU - Larsson S AD - Qbtech AB, Medical Department, Cardellgatan 1, 11436 Stockholm, Sweden. FAU - Casals, Nuria AU - Casals N AD - Qbtech AB, Medical Department, Cardellgatan 1, 11436 Stockholm, Sweden. FAU - Nolen, Robert AU - Nolen R AD - Qbtech, Inc., Medical Department, 8 Greenway Plaza, Suite 750, Houston, TX 77046, United States. FAU - Sanyal, Ragini Yallampalli AU - Sanyal RY AD - Qbtech, Inc., Medical Department, 8 Greenway Plaza, Suite 750, Houston, TX 77046, United States. FAU - Hansen, Mikkel AU - Hansen M AD - Qbtech AB, Medical Department, Cardellgatan 1, 11436 Stockholm, Sweden. LA - eng PT - Journal Article DEP - 20251122 PL - United Arab Emirates TA - Clin Pract Epidemiol Ment Health JT - Clinical practice and epidemiology in mental health : CP & EMH JID - 101245735 PMC - PMC12895433 OTO - NOTNLM OT - Attention deficit hyperactivity disorder OT - Mental health interventions OT - Psychometric test OT - QbMobile OT - QbTest OT - Smartphone COIS- The authors are employed at either Qbtech AB, Stockholm, Sweden or Qbtech, Inc. Houston, TX, USA, the company that manufactures QbMobile. The writing and evaluation of the manuscript was developed within the medical department but was not influenced by Qbtech AB'. EDAT- 2026/02/16 12:32 MHDA- 2026/02/16 12:33 PMCR- 2025/11/22 CRDT- 2026/02/16 06:44 PHST- 2025/09/24 00:00 [received] PHST- 2025/10/21 00:00 [revised] PHST- 2025/11/05 00:00 [accepted] PHST- 2026/02/16 12:33 [medline] PHST- 2026/02/16 12:32 [pubmed] PHST- 2026/02/16 06:44 [entrez] PHST- 2025/11/22 00:00 [pmc-release] AID - CPEMH-21-E17450179444324 [pii] AID - 10.2174/0117450179444324251118134538 [doi] PST - epublish SO - Clin Pract Epidemiol Ment Health. 2025 Nov 22;21:e17450179444324. doi: 10.2174/0117450179444324251118134538. eCollection 2025. PMID- 41694472 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260216 LR - 20260218 IS - 1976-1457 (Print) IS - 2005-6168 (Electronic) IS - 1976-1457 (Linking) VI - 20 IP - 1 DP - 2026 Feb TI - Development and usability evaluation of a web-based healthy eating practice questionnaire for Korean preschool children: a child-parent dyad approach. PG - 132-144 LID - 10.4162/nrp.2026.20.1.132 [doi] AB - BACKGROUND/OBJECTIVES: The illustrated Healthy Eating Practice Questionnaire (HEPQ) was previously developed to assess food preferences, eating behaviors, hand/oral hygiene practices, and nutrition knowledge among Korean preschool children. Nevertheless, the lack of an integrated scoring system has limited its interpretability. This study developed a scoring system and a web-based platform with tailored feedback using a child-parent dyad approach. SUBJECTS/METHODS: The development process consisted of 5 phases: 1) questionnaire preparation for online use, 2) formulation of the scoring system, 3) determination of the cut-off values for three levels of healthy eating practices based on a child-parent survey, 4) technical development of the online platform, and 5) usability evaluation. A scoring system was established by standardizing the domain scores to a 100-point scale. One hundred child-parent pairs participated in the survey to calculate the Healthy Eating Practice Score (HEPS) and determine cut-off values for the HEPS levels. The validity of the cut-off values was examined by a comparison with the Nutrition Quotient for Preschoolers (NQ-P). A web-based platform was developed, and 47 child-parent pairs were used to assess its usability. RESULTS: Significant positive correlations were observed between child and parent HEPS across all domains. The HEPS-based classification showed good discriminative ability because higher HEPS levels were consistently associated with higher NQ-P scores in children and parents. The web-based HEPQ was easy to use and understand, and almost all participants (97.9% of children and 93.6% of parents) reported no difficulties using the platform. CONCLUSION: The web-based HEPQ platform with an integrated scoring system provides a valid, user-friendly tool for assessing and interpreting healthy eating practices in preschool children. This platform supports parental engagement in children's healthy eating practices and provides a practical tool for evaluating the effectiveness of nutrition education in early childcare settings. CI - (c)2026 The Korean Nutrition Society and the Korean Society of Community Nutrition. FAU - Han, Young-Hee AU - Han YH AUID- ORCID: 0000-0003-1869-5675 AD - Department of Food and Nutrition, Chungbuk National University, Cheongju 28644, Korea. FAU - Park, Dawon AU - Park D AUID- ORCID: 0009-0004-0135-3366 AD - Department of Food and Nutrition, Chungbuk National University, Cheongju 28644, Korea. FAU - Kim, Dahyeon AU - Kim D AUID- ORCID: 0009-0003-0336-1266 AD - Department of Food and Nutrition, Chungbuk National University, Cheongju 28644, Korea. FAU - Shin, Saerom AU - Shin S AUID- ORCID: 0000-0003-1532-7228 AD - National Institute of Food & Nutrition Service, Cheongju 28160, Korea. FAU - Woo, Eun Yeol AU - Woo EY AUID- ORCID: 0000-0003-0686-3272 AD - National Institute of Food & Nutrition Service, Cheongju 28160, Korea. FAU - Park, Hye-Kyung AU - Park HK AUID- ORCID: 0000-0003-4864-3999 AD - National Institute of Food & Nutrition Service, Cheongju 28160, Korea. FAU - Hyun, Taisun AU - Hyun T AUID- ORCID: 0000-0002-6888-1612 AD - Department of Food and Nutrition, Chungbuk National University, Cheongju 28644, Korea. LA - eng PT - Journal Article DEP - 20260130 PL - Korea (South) TA - Nutr Res Pract JT - Nutrition research and practice JID - 101311052 PMC - PMC12893856 OTO - NOTNLM OT - Preschool children OT - eating behavior OT - food preferences OT - online systems OT - questionnaire COIS- Conflict of Interest: The authors declare no potential conflicts of interests. EDAT- 2026/02/16 12:30 MHDA- 2026/02/16 12:31 PMCR- 2026/02/01 CRDT- 2026/02/16 06:40 PHST- 2026/01/05 00:00 [received] PHST- 2026/01/20 00:00 [revised] PHST- 2026/01/21 00:00 [accepted] PHST- 2026/02/16 12:31 [medline] PHST- 2026/02/16 12:30 [pubmed] PHST- 2026/02/16 06:40 [entrez] PHST- 2026/02/01 00:00 [pmc-release] AID - 10.4162/nrp.2026.20.1.132 [doi] PST - ppublish SO - Nutr Res Pract. 2026 Feb;20(1):132-144. doi: 10.4162/nrp.2026.20.1.132. Epub 2026 Jan 30. PMID- 41694124 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260216 LR - 20260218 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 16 DP - 2025 TI - Effectiveness of music therapy for children with autism spectrum disorder: meta-analysis and potential biological mechanisms. PG - 1722874 LID - 10.3389/fpsyt.2025.1722874 [doi] LID - 1722874 AB - OBJECTIVES: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social interaction, communication skills, and repetitive behaviors. However, no effective pharmacological treatments targeting core symptoms have yet been developed. As a non-pharmacological intervention, music therapy (MT) is increasingly being explored for its potential value in improving functional outcomes for children with autism. This study aims to examine the efficacy of MT for children with ASD through a meta-analysis. METHOD: We conducted a systematic review following the PRISMA guidelines. A comprehensive and systematic search of PubMed, Web of Science, and the Cochrane Library databases up to August 2025 was performed to identify studies on MT treatment for children with ASD. Continuous variables were reported as standardized mean differences (SMD) with 95% confidence intervals (CI). All analyses were conducted using Stata statistical software version 17.0. RESULTS: Our meta-analysis included 18 studies. Results showed that MT significantly reduced the total score on the Autism Behavior Checklist (ABC) (SMD = -0.76, 95% CI: -1.31 to -0.22, P = 0.01) and Childhood Autism Rating Scale (CARS) total scores (SMD = -0.43, 95% CI: -0.73 to -0.14, P < 0.01). Specifically, compared with the control group, MT significantly improved social skills (SMD = -0.26, 95% CI: -0.46 to -0.05, P = 0.01), behavioral abilities (SMD = -0.72, 95% CI: -1.06 to -0.39, P < 0.01), and sensory (SMD = -0.87, 95% CI: -1.68 to -0.07, P = 0.03), emotional (SMD = -1.31, 95% CI: -1.98 to -0.64, P < 0.01), and verbal functioning (SMD = -0.65, 95% CI: -0.19 to 1.12, P = 0.01). CONCLUSION: In summary, MT demonstrates efficacy in improving behavioral symptoms associated with autism spectrum disorders. However, caution should be exercised when interpreting results due to limited research literature in some analyses. Further studies are needed to validate its therapeutic effects. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/, identifier CRD420251252228. CI - Copyright (c) 2026 Wu, Zhang, Liu, Gao and Wang. FAU - Wu, Li AU - Wu L AD - School of Music and Dance, South-Central Minzu University, Wuhan, Hubei, China. FAU - Zhang, Xinming AU - Zhang X AD - National 111 Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, Hubei, China. AD - International Center for Redox Biology and Precision Medicine of Hubei Province, Hubei University of Technology, Wuhan, Hubei, China. AD - Hubei University of Technology Autism and Depression Diagnosis and Intervention Institute, Hubei University of Technology, Wuhan, Hubei, China. FAU - Liu, Shuyue AU - Liu S AD - National 111 Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, Hubei, China. AD - International Center for Redox Biology and Precision Medicine of Hubei Province, Hubei University of Technology, Wuhan, Hubei, China. AD - Hubei University of Technology Autism and Depression Diagnosis and Intervention Institute, Hubei University of Technology, Wuhan, Hubei, China. FAU - Gao, Xinping AU - Gao X AD - Ningbo Symphony Orchestra, Ningbo, Zhejiang, China. FAU - Wang, Jun AU - Wang J AD - National 111 Center for Cellular Regulation and Molecular Pharmaceutics, Hubei University of Technology, Wuhan, Hubei, China. AD - International Center for Redox Biology and Precision Medicine of Hubei Province, Hubei University of Technology, Wuhan, Hubei, China. AD - Hubei University of Technology Autism and Depression Diagnosis and Intervention Institute, Hubei University of Technology, Wuhan, Hubei, China. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260130 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC12900671 OTO - NOTNLM OT - autism spectrum disorder OT - children OT - mechanism OT - meta-analysis OT - music therapy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/16 12:31 MHDA- 2026/02/16 12:32 PMCR- 2026/01/30 CRDT- 2026/02/16 06:37 PHST- 2025/10/14 00:00 [received] PHST- 2025/12/22 00:00 [revised] PHST- 2025/12/26 00:00 [accepted] PHST- 2026/02/16 12:32 [medline] PHST- 2026/02/16 12:31 [pubmed] PHST- 2026/02/16 06:37 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - 10.3389/fpsyt.2025.1722874 [doi] PST - epublish SO - Front Psychiatry. 2026 Jan 30;16:1722874. doi: 10.3389/fpsyt.2025.1722874. eCollection 2025. PMID- 41693999 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260216 LR - 20260218 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Influence of family support on leisure activities and mental health in times of health crisis. PG - 1736074 LID - 10.3389/fpsyg.2026.1736074 [doi] LID - 1736074 AB - Physical activity is an essential pillar for promoting health and comprehensive well-being throughout life. During the COVID-19 pandemic, lockdown and social restriction measures significantly transformed family routines and lifestyles, leading to an increase in sedentary behavior and negative effects on mental health. This article aims to analyze the influence of family support on mental health, mediated by physical activity and sedentary behaviors during the COVID-19 lockdown. A total of 1,345 Mexican adults (68.1% women) participated, responding to validated instruments: the Social Support for Physical Activity Scale, the Godin-Shephard Leisure-Time Physical Activity Questionnaire, the Youth Leisure-Time Sedentary Behavior Questionnaire, and the Positive and Negative Affect Schedule (PANAS). Structural equation modeling analyses showed a satisfactory model fit (chi(2)/df = 6.71, CFI = 0.931, RMSEA = 0.060). Family support was positively associated with active leisure and, more weakly, with passive leisure. Furthermore, active leisure was related to greater positive affect, while passive leisure was associated with psychological distress. These results highlight the protective role of the family in promoting physical activity and emotional regulation in lockdown contexts. It is recommended to design family intervention programs that integrate educational, affective, and behavioral components to foster active lifestyles and strengthen resilience for future health crises. CI - Copyright (c) 2026 Garcia-Gallegos, Delgado-Herrada, Morquecho-Sanchez, Leale and Zamarripa. FAU - Garcia-Gallegos, Janeth Berenice AU - Garcia-Gallegos JB AD - Universidad Autonoma de Occidente, Unidad Regional Guasave, Culiacan, Mexico. FAU - Delgado-Herrada, Maritza AU - Delgado-Herrada M AD - Secretaria de Ciencia, Humanidades, Tecnologia e Innovacion (SECIHTI), Mexico City, Mexico. FAU - Morquecho-Sanchez, Raquel AU - Morquecho-Sanchez R AD - Facultad de Organizacion Deportiva, Universidad Autonoma de Nuevo Leon, Nuevo Leon, Mexico. FAU - Leale, Ignazio AU - Leale I AD - Department of Psychology, Educational Sciences and Human Movement, Sport and Exercise Research Unit, Palermo, Italy. FAU - Zamarripa, Jorge AU - Zamarripa J AD - Facultad de Organizacion Deportiva, Universidad Autonoma de Nuevo Leon, Nuevo Leon, Mexico. LA - eng PT - Journal Article DEP - 20260129 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12904146 OTO - NOTNLM OT - COVID-19 OT - Mexico OT - family support OT - lockdown OT - physical activity OT - sedentary behaviors COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor DMS declared a past co-authorship with the author IL. EDAT- 2026/02/16 12:31 MHDA- 2026/02/16 12:32 PMCR- 2026/01/29 CRDT- 2026/02/16 06:37 PHST- 2025/10/30 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2026/01/09 00:00 [accepted] PHST- 2026/02/16 12:32 [medline] PHST- 2026/02/16 12:31 [pubmed] PHST- 2026/02/16 06:37 [entrez] PHST- 2026/01/29 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1736074 [doi] PST - epublish SO - Front Psychol. 2026 Jan 29;17:1736074. doi: 10.3389/fpsyg.2026.1736074. eCollection 2026. PMID- 41693527 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260721 IS - 1755-5949 (Electronic) IS - 1755-5930 (Print) IS - 1755-5930 (Linking) VI - 32 IP - 2 DP - 2026 Feb TI - Digital Sleep Disruption: Unraveling the Network Structure of Technology Use and Sleep Problems Through Network Analysis. PG - e70778 LID - 10.1002/cns.70778 [doi] LID - e70778 AB - BACKGROUND: Sleep problems have emerged as a critical health concern in the digital age, yet the complex mechanisms linking technology use to sleep disruption remain poorly understood. Previous research has typically examined isolated relationships between specific technological behaviors and sleep outcomes, overlooking the complex interplay among various digital factors. This study aims to address this gap by employing network analysis to investigate the interconnected relationships among multiple technology-related factors and their collective influence on sleep problems. METHODS: Using network analysis, this study examined how different aspects of digital technology use collectively influence sleep problems in a large sample of Chinese adults (N = 9443). Participants were recruited through stratified random sampling based on age groups and geographical regions, with the sample size determined a priori using Monte Carlo simulations to ensure stable network estimation. Participants completed validated measures assessing screen time, before-bed electronic device use, electronic device dependency, social media anxiety, digital information overload, virtual social pressure, blue light exposure, circadian rhythm disruption, online gaming addiction, work-life digital integration, and sleep problems. Participants with diagnosed sleep disorders, those engaged in shift work, or those who had traveled across time zones in the past month were excluded to minimize confounding effects on natural sleep patterns. RESULTS: Network analysis revealed complex interconnections among technology-related factors and sleep problems. Blue light exposure demonstrated the strongest direct edge weight with sleep problems (r = 0.31, p < 0.001), followed by circadian rhythm disturbance (r = 0.26, p < 0.001). The network structure indicated that screen time, bedtime device use, electronic device dependence, virtual social pressure, and work-life digital integration showed weaker direct associations with sleep problems but demonstrated substantial indirect pathways through intermediate variables. Online gaming addiction, digital information overload, social media anxiety, and circadian rhythm disturbance exhibited moderate centrality indices, suggesting their role as potential mediators within the network. CONCLUSIONS: These findings advance our understanding of technology-induced sleep disruption and suggest potential targets for intervention. The network approach reveals that addressing sleep problems in the digital age requires consideration of both direct physiological impacts and indirect psychological pathways. The identification of specific factors with high centrality provides empirical guidance for developing targeted intervention strategies. CI - (c) 2026 The Author(s). CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd. FAU - Gan, Haoqing AU - Gan H AD - Department of Emergency, Shaoxing Second Hospital, Shaoxing, Zhejiang, China. AD - School of Medicine, Shaoxing University, Shaoxing, Zhejiang, China. FAU - Xu, Lingjia AU - Xu L AUID- ORCID: 0000-0002-9635-2056 AD - School of Medicine, Shaoxing University, Shaoxing, Zhejiang, China. AD - Department of Neurology, Shaoxing Second Hospital, Shaoxing, Zhejiang, China. FAU - Tong, Chenglin AU - Tong C AUID- ORCID: 0009-0008-3996-417X AD - Department of Emergency, Shaoxing Second Hospital, Shaoxing, Zhejiang, China. AD - School of Medicine, Shaoxing University, Shaoxing, Zhejiang, China. LA - eng GR - 2025KY402/the Medical and Health Research Projects of Health Commission of Zhejiang Province/ PT - Journal Article PL - England TA - CNS Neurosci Ther JT - CNS neuroscience & therapeutics JID - 101473265 SB - IM MH - Humans MH - *Sleep Wake Disorders/epidemiology/psychology/etiology MH - Female MH - Digital Media MH - Male MH - Adult MH - Young Adult MH - *Digital Technology MH - Circadian Rhythm MH - Middle Aged MH - Adolescent MH - Blue Light PMC - PMC12907764 OTO - NOTNLM OT - blue light exposure OT - circadian rhythm OT - digital technology OT - network analysis OT - psychological mechanisms OT - sleep problems COIS- The authors declare no conflicts of interest. EDAT- 2026/02/16 06:30 MHDA- 2026/02/16 06:31 PMCR- 2026/02/16 CRDT- 2026/02/16 04:42 PHST- 2026/01/21 00:00 [revised] PHST- 2025/10/23 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/02/16 06:31 [medline] PHST- 2026/02/16 06:30 [pubmed] PHST- 2026/02/16 04:42 [entrez] PHST- 2026/02/16 00:00 [pmc-release] AID - CNS70778 [pii] AID - 10.1002/cns.70778 [doi] PST - ppublish SO - CNS Neurosci Ther. 2026 Feb;32(2):e70778. doi: 10.1002/cns.70778. PMID- 41693143 OWN - NLM STAT- MEDLINE DCOM- 20260608 LR - 20260609 IS - 1099-0968 (Electronic) IS - 1072-4133 (Linking) VI - 34 IP - 4 DP - 2026 Jul TI - Assessment of Maladaptive Exercise History Among Individuals With Eating Disorders: Validation of a Brief, Self-Report Measure. PG - 1003-1015 LID - 10.1002/erv.70084 [doi] AB - OBJECTIVE: Maladaptive exercise is a common symptom of eating disorders (EDs). While several measures exist to assess current maladaptive exercise, there are no validated self-report tools to assess maladaptive exercise history-an important symptom domain among individuals with lifetime EDs. METHOD: Using data from a large sample of individuals with at least one lifetime ED diagnosis across four countries (N = 31,670), the current study aimed to validate and refine the Eating Disorders 100,000 Questionnaire-version 3 exercise items to create a brief measure of lifetime and current maladaptive exercise, suitable for large-scale epidemiological research and clinical screenings. RESULTS: Five non-redundant operationalisations of maladaptive exercise were identified ('Any Maladaptive Exercise', 'Regular Maladaptive Exercise', 'Compensatory Exercise', 'Excessive Exercise', 'Current Maladaptive Exercise'). Maladaptive exercise history was present across all lifetime ED presentations assessed, though endorsement levels varied based on scoring operationalisation. Individuals reporting a history of anorexia nervosa reported the highest levels of endorsement of most constructs, closely followed by bulimia nervosa. Compensatory exercise was endorsed most frequently among those reporting a history of bulimia nervosa relative to other diagnostic groups. CONCLUSIONS: Six key items were recommended as a brief screening assessment to capture maladaptive exercise history in EDs. TRIAL REGISTRATION: EDGI is a registered clinical trial (clinicaltrials.gov ID: NCT04378101). CI - (c) 2026 The Author(s). European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd. FAU - Schaumberg, Katherine AU - Schaumberg K AD - Department of Psychology, University of Texas at Austin, Austin, Texas, USA. AD - Department of Psychiatry, University of Wisconsin, Madison, Wisconsin, USA. FAU - Watson, Hunna J AU - Watson HJ AUID- ORCID: 0000-0001-8405-381X AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Discipline of Psychology, School of Population Health, Curtin University, Bentley, Australia. AD - Division of Paediatrics, School of Medicine, University of Western Australia, Perth, Australia. FAU - Thornton, Laura M AU - Thornton LM AUID- ORCID: 0000-0001-9384-7988 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Kennedy, Hannah L AU - Kennedy HL AD - Department of Psychological Medicine, University of Otago Christchurch, Christchurch, New Zealand. FAU - Ong, Shu H AU - Ong SH AD - InsideOut Institute for Eating Disorders, The University of Sydney, Sydney, Australia. FAU - Roche, Preston AU - Roche P AD - Department of Psychiatry, University of Texas-San Antonio, San Antonio, Texas, USA. FAU - Costello, Kayla AU - Costello K AUID- ORCID: 0000-0002-5486-9647 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Department of Psychology, University at Albany, State University of New York, Albany, New York, USA. FAU - Barnhart, Wesley R AU - Barnhart WR AUID- ORCID: 0000-0002-9809-5225 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Department of Psychology, Bowling Green State University, Bowling Green, Ohio, USA. AD - Suffolk University, Boston, Massachusetts, USA. FAU - Pauley-Gadd, Sian B AU - Pauley-Gadd SB AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Faculty of Health Sciences, enAble Institute, Curtin University, Bentley, Australia. FAU - Flatt, Rachael E AU - Flatt RE AUID- ORCID: 0000-0002-2661-7987 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Birgegard, Andreas AU - Birgegard A AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Dinkler, Lisa AU - Dinkler L AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Abbaspour, Afrouz AU - Abbaspour A AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Mantilla, Emma Forsen AU - Mantilla EF AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. AD - Department of Physical Activity and Health, Swedish School of Sport and Health Sciencest, Stockholm, Sweden. FAU - Monell, Elin AU - Monell E AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. AD - Department of Clinical Neuroscience, Karolinska Institutet and Stockholm Health Care Servicest, Stockholm, Sweden. FAU - Frans, Emma M AU - Frans EM AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. FAU - Barakat, Sarah AU - Barakat S AD - InsideOut Institute for Eating Disorders, The University of Sydney, Sydney, Australia. FAU - Pettie, Michaela A AU - Pettie MA AUID- ORCID: 0000-0001-5466-8848 AD - Department of Pathology and Biomedical Science, University of Otago Christchurch, Christchurch, New Zealand. FAU - Parker, Richard AU - Parker R AD - QIMR Berghofer Medical Research Institute, University of Queensland, Brisbane, Queensland, USA. FAU - Maguire, Sarah AU - Maguire S AUID- ORCID: 0000-0003-0754-9189 AD - InsideOut Institute for Eating Disorders, The University of Sydney, Sydney, Australia. FAU - Jordan, Jennifer AU - Jordan J AUID- ORCID: 0000-0003-4699-6301 AD - QIMR Berghofer Medical Research Institute, University of Queensland, Brisbane, Queensland, USA. AD - Specialist Mental Health Clinical Research Unit, Te Whatu Ora Waitaha Canterbury, Christchurch, New Zealand. FAU - Kennedy, Martin A AU - Kennedy MA AD - Department of Pathology and Biomedical Science, University of Otago Christchurch, Christchurch, New Zealand. FAU - Morancie, Nailah Adams AU - Morancie NA AD - Department of Family Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Bulik, Cynthia M AU - Bulik CM AUID- ORCID: 0000-0001-7772-3264 AD - Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. AD - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. AD - Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. LA - eng SI - ClinicalTrials.gov/NCT04378101 GR - L30MH120619/MH/NIMH NIH HHS/United States GR - K01MH123914/MH/NIMH NIH HHS/United States GR - R56MH129437/MH/NIMH NIH HHS/United States GR - R01MH120170/MH/NIMH NIH HHS/United States GR - R01MH124871/MH/NIMH NIH HHS/United States GR - R01MH119084/MH/NIMH NIH HHS/United States GR - R01MH118278/MH/NIMH NIH HHS/United States GR - U01MH109528/MH/NIMH NIH HHS/United States GR - R276-2018-4581/Lundbeck Foundation/ GR - 538-2013-8864/Vetenskapsradet/ GR - PG-22-0478/Swedish Society for Medical Research/ GR - Swedish Mental Health Foundation/ GR - Fredrik och Ingrid Thurings Stiftelse/ GR - L30MH120619/MH/NIMH NIH HHS/United States GR - K01MH123914/MH/NIMH NIH HHS/United States GR - R56MH129437/MH/NIMH NIH HHS/United States GR - R01MH120170/MH/NIMH NIH HHS/United States GR - R01MH124871/MH/NIMH NIH HHS/United States GR - R01MH119084/MH/NIMH NIH HHS/United States GR - R01MH118278/MH/NIMH NIH HHS/United States GR - U01MH109528/MH/NIMH NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20260215 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Exercise/psychology MH - *Feeding and Eating Disorders/psychology/diagnosis MH - Reproducibility of Results MH - *Self Report/standards MH - Surveys and Questionnaires MH - Observational Studies as Topic MH - Multicenter Studies as Topic OTO - NOTNLM OT - compulsive exercise OT - cross-cultural validation OT - eating disorders OT - eating disorders genetics initiative OT - screening EDAT- 2026/02/16 06:30 MHDA- 2026/06/08 12:38 CRDT- 2026/02/16 00:54 PHST- 2026/01/03 00:00 [revised] PHST- 2025/11/24 00:00 [received] PHST- 2026/01/15 00:00 [accepted] PHST- 2026/06/08 12:38 [medline] PHST- 2026/02/16 06:30 [pubmed] PHST- 2026/02/16 00:54 [entrez] AID - 10.1002/erv.70084 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2026 Jul;34(4):1003-1015. doi: 10.1002/erv.70084. Epub 2026 Feb 15. PMID- 41692591 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260727 IS - 1460-2210 (Electronic) IS - 0141-5387 (Linking) VI - 48 IP - 1 DP - 2025 Dec 16 TI - A modified clear twin block appliance for treatment of class II malocclusion: a randomized clinical trial. LID - cjaf103 [pii] LID - 10.1093/ejo/cjaf103 [doi] AB - BACKGROUND: Skeletal Class II malocclusion is commonly treated with functional appliances, but bulkiness and discomfort usually affect the compliance. Modifications of these appliances using clear thermoplastic materials could improve comfort and esthetics; though clinical evidence remains limited. OBJECTIVE: To assess the clinical effectiveness of a Modified Twin Block (MTB) appliance, fabricated from 2 mm biocompatible polyethylene terephthalate modified with Glycol (PETG) thermoplastic material, in comparison with the Conventional Twin Block (CTB), for treatment of skeletal Class II due to mandibular retrognathism. SUBJECTS AND METHODS: This multicenter, single-blinded randomized clinical trial included 50 adolescents, at the peak of pubertal growth (CS -3). Patients were randomly assigned to two parallel groups treated with either a CTB or MTB appliance, both incorporating a midline screw for maxillary expansion. Appliances were worn full-time and the expander was activated twice weekly. The records including cephalograms were taken pre- and post-treatment to evaluate skeletal (sagittal and vertical) and soft tissue changes. Dental arch expansion was assessed using standardized 3D digital model superimposition on palatal landmarks, and overjet/overbite changes were clinically recorded. Patient perception was evaluated using a validated questionnaire. Data were analyzed using paired and independent t-tests. RESULTS: All patients completed the trial without dropout. Baseline characteristics were comparable between groups, with no significant differences in 20 out of 24 variables. Both the CTB and MTB groups showed significant improvements in skeletal, soft tissue, and dental parameters post-treatment (P < 0.05). Between-group comparison revealed a statistically significant improvement in ANB angle favoring the MTB group (P = 0.004), while vertical skeletal and soft tissue changes showed no significant differences (P > 0.05). The MTB group also demonstrated a significantly greater overbite reduction (P = 0.005) and higher dental arch expansion (P = 0.001), particularly in the molar region. No significant difference was found in active treatment duration. Patient perception data showed significantly more favorable experiences with the MTB appliance in 13 out of 36 questionnaire items, particularly regarding comfort, hygiene, function, and psychosocial impact. LIMITATIONS: Double blinding was not feasible due to clear visual differences between the appliances. CONCLUSIONS: The MTB appliance is effective in treating growing patients with skeletal Class II due to mandibular retrognathism and is comparable with slight advantageous results to CTB appliance. TRIAL REGISTRATION: NCT06116500. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the European Orthodontic Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Haik, Anosh A AU - Haik AA AD - Baghdad Health Department, Rusafa, Ministry of Health, Baghdad 10045, Iraq. FAU - Yassir, Yassir A AU - Yassir YA AUID- ORCID: 0000-0001-9577-8947 AD - Department of Orthodontics, College of Dentistry, University of Baghdad, Baghdad 10047, Iraq. AD - School of Dentistry, University of Dundee, Dundee DD1 4HN, United Kingdom. LA - eng SI - ClinicalTrials.gov/NCT06116500 PT - Comparative Study PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial PL - England TA - Eur J Orthod JT - European journal of orthodontics JID - 7909010 SB - IM MH - Humans MH - Single-Blind Method MH - *Orthodontic Appliance Design MH - Female MH - *Malocclusion, Angle Class II/therapy MH - *Palatal Expansion Technique/instrumentation MH - Cephalometry/methods MH - Adolescent MH - Male MH - *Orthodontic Appliances, Functional MH - Treatment Outcome MH - Retrognathia/therapy/complications MH - Patient Satisfaction MH - Child MH - Mandible/pathology OTO - NOTNLM OT - PETG OT - clinical trial OT - expander OT - patient satisfaction OT - twin block COIS- Conflict of interest: There is nothing to declare. EDAT- 2026/02/16 00:31 MHDA- 2026/02/16 00:32 CRDT- 2026/02/15 21:32 PHST- 2026/02/16 00:32 [medline] PHST- 2026/02/16 00:31 [pubmed] PHST- 2026/02/15 21:32 [entrez] AID - 8484234 [pii] AID - 10.1093/ejo/cjaf103 [doi] PST - ppublish SO - Eur J Orthod. 2025 Dec 16;48(1):cjaf103. doi: 10.1093/ejo/cjaf103. PMID- 41692491 OWN - NLM STAT- MEDLINE DCOM- 20260708 LR - 20260911 IS - 2059-7908 (Print) IS - 2059-7908 (Electronic) IS - 2059-7908 (Linking) VI - 10 IP - Suppl 4 DP - 2026 Feb 15 TI - A research agenda for digital payments of health workers in large-scale health campaigns in sub-Saharan Africa. LID - 10.1136/bmjgh-2024-017476 [doi] LID - e017476 AB - INTRODUCTION: Digital payments are increasingly favoured over cash for remunerating healthcare workers in large-scale health campaigns due to perceived advantages in efficiency and security. However, evidence to guide their scaling and optimisation is limited. This study aimed to identify and prioritise a global research agenda for digital payments in health campaigns in sub-Saharan Africa (SSA). METHODS: We employed the Child Health and Nutrition Research Initiative methodology. In stage 1, we defined the context and criteria (answerability, feasibility, sustainability/equity, impact). In stage 2, 420 stakeholders were engaged via an online survey, generating 450 research questions, which were refined to a final pool of 35. In stage 3, these 35 questions were scored by 63 experts against the predefined criteria. Research Priority Scores (RPS) and Average Expert Agreement (AEA) were computed for ranking in stage 4. RESULTS: The overall RPS for the 35 questions ranged from 38.6% to 6.0% (mean 28.2%, SD 6.4%). The AEA ranged from 67.2% to 82.7% (mean 77%, SD 3.4%), indicating strong consensus. RPS and AEA showed a strong positive correlation (r=0.989, p<0.01). The top-ranked research questions were: (1) Minimum requirements for health systems to digitise payments responsibly (RPS 38.6%); (2) Optimisation of digital payments to enhance campaign effectiveness in SSA (RPS 36.8%); (3) Incentives for digital payment adoption in the healthcare sector (RPS 36.1%); (4) Cost-benefit analysis of digital payments vs cash (RPS 36.3%) and (5) Coverage of mobile money agents and its impact on uptake and satisfaction (RPS 34.0%). CONCLUSIONS: This study provides an expert-consensus roadmap for research on digital payments in health campaigns. Addressing these priorities will generate critical evidence to develop robust, equitable and effective digital payment systems, ultimately strengthening health systems and improving health outcomes in SSA. CI - (c) World Health Organization 2026. Licensee BMJ. FAU - Waiswa, Peter AU - Waiswa P AD - Health Policy, Planning and Management, Makerere University College of Health Sciences, Kampala, Central Region, Uganda pwaiswa@musph.ac.ug. AD - Global Public Health, Karolinska Institute, Stockholm, Sweden. FAU - Aweko, Juliet AU - Aweko J AUID- ORCID: 0000-0001-7448-6726 AD - Health Policy, Planning and Management, Makerere University College of Health Sciences, Kampala, Central Region, Uganda. FAU - Opio, Charles AU - Opio C AD - Health Policy, Planning and Management, Makerere University College of Health Sciences, Kampala, Central Region, Uganda. FAU - Ashaba, Maggie Ssekitto AU - Ashaba MS AUID- ORCID: 0009-0000-0782-0886 AD - Health Policy, Planning and Management, Makerere University College of Health Sciences, Kampala, Central Region, Uganda. FAU - Igbokwe, Uchenna AU - Igbokwe U AD - Solina Centre for International Development and Research, Abuja, Nigeria. FAU - Aigbogun, Eric AU - Aigbogun E AD - Solina Centre for International Development and Research, Abuja, Nigeria. FAU - Mboup, Zahra AU - Mboup Z AD - Universite Cheikh Anta Diop, Dakar, Senegal. FAU - Ndiaye, Souleymane AU - Ndiaye S AD - Universite Cheikh Anta Diop, Dakar, Senegal. FAU - Faye, Adama AU - Faye A AD - Universite Cheikh Anta Diop, Dakar, Senegal. FAU - Bakainaga, Andrew AU - Bakainaga A AD - World Health Organization, Kampala, Uganda. FAU - Ekirapa Kiracho, Elizabeth AU - Ekirapa Kiracho E AUID- ORCID: 0000-0001-6938-2068 AD - Health Policy, Planning and Management, Makerere University College of Health Sciences, Kampala, Central Region, Uganda. LA - eng GR - INV-03047/the Bill & Melinda Gates Foundation/ PT - Journal Article DEP - 20260215 PL - England TA - BMJ Glob Health JT - BMJ global health JID - 101685275 SB - IM MH - Humans MH - Africa South of the Sahara MH - *Health Promotion/economics MH - *Health Personnel/economics MH - Digital Media MH - Digital Health MH - Surveys and Questionnaires PMC - PMC12962003 OTO - NOTNLM OT - Child health OT - Global Health OT - Health systems OT - Immunisation OT - Public Health COIS- Competing interests: None declared. EDAT- 2026/02/16 00:31 MHDA- 2026/02/16 00:32 PMCR- 2026/02/15 CRDT- 2026/02/15 20:42 PHST- 2024/12/02 00:00 [received] PHST- 2025/12/22 00:00 [accepted] PHST- 2026/02/16 00:32 [medline] PHST- 2026/02/16 00:31 [pubmed] PHST- 2026/02/15 20:42 [entrez] PHST- 2026/02/15 00:00 [pmc-release] AID - bmjgh-2024-017476 [pii] AID - 10.1136/bmjgh-2024-017476 [doi] PST - epublish SO - BMJ Glob Health. 2026 Feb 15;10(Suppl 4):e017476. doi: 10.1136/bmjgh-2024-017476. PMID- 41691340 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260325 LR - 20260813 IS - 1710-1484 (Print) IS - 1710-1492 (Electronic) IS - 1710-1484 (Linking) VI - 22 IP - 1 DP - 2026 Feb 15 TI - Frey's syndrome in an infant misdiagnosed as food allergy. LID - 10.1186/s13223-026-01015-3 [doi] LID - 12 AB - BACKGROUND: Frey's syndrome (auriculotemporal syndrome) is characterized by gustatory flushing and sweating in the distribution of the auriculotemporal nerve. Although classically described after parotid surgery in adults, congenital and idiopathic forms are increasingly recognized in infants. Because symptoms occur during feeding, the condition can closely mimic IgE-mediated food allergy, leading to unnecessary dietary restrictions and anxiety. CASE PRESENTATION: We report an 8-month-old boy referred for evaluation of suspected multiple food allergies after several emergency department visits for feeding-associated facial redness, interpreted by caregivers as "hives", and accompanied by significant parental anxiety and progressive dietary avoidance. On detailed reassessment, reactions were found to consist of localized, unilateral flushing and sweating of the right cheek, without urticaria or systemic features. Skin prick testing and serum-specific IgE testing to common food allergens were negative. During a supervised baked milk oral food challenge, a similar unilateral cutaneous reaction was observed, confirming the diagnosis of Frey's syndrome. A home-recorded video demonstrated comparable findings during feeding with formula. DISCUSSION: Frey's syndrome is an important and under-recognized mimic of food allergy in infancy. Careful attention to laterality, absence of systemic involvement, and reproducibility across foods can prevent misdiagnosis, reduce unnecessary dietary restriction, and alleviate family anxiety. CONCLUSION: Frey's syndrome should be considered in infants with reproducible unilateral flushing during feeding. Awareness among allergists can prevent misdiagnosis, reduce unnecessary food avoidance, and support safe nutritional and developmental outcomes. CI - (c) 2026. The Author(s). FAU - Semaan, Melanie AU - Semaan M AD - Division of Clinical Immunology and Allergy, Department of Medicine, Western University, 268 Grosvenor Street, London, ON, N6A 4V2, Canada. FAU - Alkhuder, Sheikha AU - Alkhuder S AD - Division of Clinical Immunology and Allergy, Department of Medicine, Western University, 268 Grosvenor Street, London, ON, N6A 4V2, Canada. FAU - Jeimy, Samira AU - Jeimy S AD - Division of Clinical Immunology and Allergy, Department of Medicine, Western University, 268 Grosvenor Street, London, ON, N6A 4V2, Canada. samira.jeimy@lhsc.on.ca. LA - eng PT - Journal Article DEP - 20260215 PL - England TA - Allergy Asthma Clin Immunol JT - Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology JID - 101244313 PMC - PMC13011496 OTO - NOTNLM OT - Auriculotemporal syndrome OT - Food allergy OT - Frey syndrome COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Written informed consent for publication of clinical details and images was obtained from the patient's legal guardian. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/02/15 00:31 MHDA- 2026/02/15 00:32 PMCR- 2026/02/15 CRDT- 2026/02/14 23:28 PHST- 2025/09/22 00:00 [received] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/02/15 00:32 [medline] PHST- 2026/02/15 00:31 [pubmed] PHST- 2026/02/14 23:28 [entrez] PHST- 2026/02/15 00:00 [pmc-release] AID - 10.1186/s13223-026-01015-3 [pii] AID - 1015 [pii] AID - 10.1186/s13223-026-01015-3 [doi] PST - epublish SO - Allergy Asthma Clin Immunol. 2026 Feb 15;22(1):12. doi: 10.1186/s13223-026-01015-3. PMID- 41690788 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260715 IS - 1945-7049 (Electronic) IS - 1061-3749 (Linking) VI - 34 IP - 2 DP - 2026 Jul 10 TI - Measurement of Human Milk Feeding Knowledge, Attitudes, Beliefs, and Self-Efficacy Among Women From Underrepresented Racial and Ethnic Populations: A Systematic Review. PG - 336-352 LID - 10.1891/JNM-2025-0026 [doi] AB - Background and Purpose: Human milk feeding inequities persist among women from underrepresented racial and ethnic populations in the United States. Knowledge, attitudes, beliefs, and self-efficacy influence human milk feeding practices. This review evaluates the measurement properties of instruments assessing these variables among underrepresented populations. Methods: A systematic review from CINAHL, MEDLINE, and PsycINFO databases evaluated instruments assessing breastfeeding variables among women from underrepresented racial and ethnic populations. Results: Fifteen instruments were assessed. The Iowa Infant Feeding Attitude Scale (IIFAS) and Breastfeeding Self-Efficacy Scale-Short Form (BSES-SF) had moderate to strong psychometric scores (alpha = .67-.86; .79-.96). Conclusions: While several instruments assess human milk feeding variables in underrepresented populations, IIFAS and BSES-SF show the strongest evidence. More culturally appropriate instruments are needed. CI - (c) 2026 Springer Publishing Company. FAU - Logan, Alicia M AU - Logan AM AD - University of Montevallo, Montevallo, AL, USA aml0179@auburn.edu alogan3@montevallo.edu. AD - College of Nursing, Auburn University, Auburn, AL, USA. FAU - Ware, Katilya S AU - Ware KS AD - College of Nursing, Auburn University, Auburn, AL, USA. FAU - Lin, Chin-Yen AU - Lin CY AD - College of Nursing, Auburn University, Auburn, AL, USA. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260710 PL - United States TA - J Nurs Meas JT - Journal of nursing measurement JID - 9318902 SB - IM MH - Humans MH - Female MH - *Breast Feeding/psychology/ethnology MH - *Health Knowledge, Attitudes, Practice/ethnology MH - *Self Efficacy MH - *Psychometrics MH - *Ethnicity/psychology/statistics & numerical data MH - United States MH - Adult MH - *Mothers/psychology/statistics & numerical data MH - *Minority Groups/psychology/statistics & numerical data MH - Infant OTO - NOTNLM OT - breastfeeding OT - human milk feeding OT - mothers of color OT - psychometrics OT - systematic review OT - women of color EDAT- 2026/02/15 00:31 MHDA- 2026/07/12 00:56 CRDT- 2026/02/14 21:12 PHST- 2026/07/12 00:56 [medline] PHST- 2026/02/15 00:31 [pubmed] PHST- 2026/02/14 21:12 [entrez] AID - JNM-2025-0026 [pii] AID - 10.1891/JNM-2025-0026 [doi] PST - epublish SO - J Nurs Meas. 2026 Jul 10;34(2):336-352. doi: 10.1891/JNM-2025-0026. PMID- 41690506 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1878-3511 (Electronic) IS - 1201-9712 (Linking) VI - 167 DP - 2026 Jun TI - Feasibility and efficacy of a population-based pulmonary rehabilitation for post-tuberculosis lung disease in Bangladesh. PG - 108477 LID - S1201-9712(26)00112-8 [pii] LID - 10.1016/j.ijid.2026.108477 [doi] AB - OBJECTIVES: The objective of this study was to evaluate the feasibility and efficacy of pulmonary rehabilitation in patients with PTLD in Bangladesh with a population-based approach. METHODS: Prospective population-based study in Bangladesh. All patients achieving treatment success were screened with a questionnaire to identify symptoms associated with PTLD. If the screening was positive, the patient underwent further assessments, like clinical examination, spirometry, and 6-Minutes Walking Test (6MWT). Based on the screening results, patients with moderate PTLD were considered eligible for a 6-week pulmonary rehabilitation programme. RESULTS: Two hundred and two patients met the inclusion criteria and were included in the analysis. After rehabilitation, forced expiratory volume in one second (FEV(1)) increased from 1.28 +/- 0.47 L to 1.36 +/- 0.51 L (P < 0.0001), forced vital capacity (FVC) increased from 2.00 +/- 0.59 L to 2.10 +/- 0.64 L (P < 0.0001), and the distance walked in 6MWT increased from 402.8 +/- 109.1 m to 456.7 +/- 108.6 m (P < 0.0001). CONCLUSION: Pulmonary rehabilitation for PTLD is feasible and effective in a limited-resource setting such as Bangladesh. We suggest that the improvement of lung function in PTLD patients undergoing pulmonary rehabilitation should be assessed and included as an expected outcome. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Rifat, Mahfuza AU - Rifat M AD - Damien Foundation, Dhaka, Bangladesh. FAU - Silva, Denise Rossato AU - Silva DR AD - Faculdade de Medicina, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brasil. FAU - Mahmud, Asif Mujtaba AU - Mahmud AM AD - Bangladesh Lung Foundation, Dhaka, Bangladesh. FAU - Bennoor, Kazi Saifuddin AU - Bennoor KS AD - Bangladesh Lung Foundation, Dhaka, Bangladesh. FAU - D'Ambrosio, Lia AU - D'Ambrosio L AD - Public Health Consulting Group, Lugano, Switzerland. FAU - Centis, Rosella AU - Centis R AD - Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy. FAU - Ardesi, Francesco AU - Ardesi F AD - Department of Medicine and Cardiopulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy; Department of Medicine and Surgery, University of Insubria, Varese, Italy. FAU - Visca, Dina AU - Visca D AD - Department of Medicine and Cardiopulmonary Rehabilitation, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy; Department of Medicine and Surgery, University of Insubria, Varese, Italy. FAU - Piubello, Alberto AU - Piubello A AD - Damien Foundation, Bruxelles, Belgium. FAU - Migliori, Giovanni Battista AU - Migliori GB AD - Servizio di Epidemiologia Clinica delle Malattie Respiratorie, Istituti Clinici Scientifici Maugeri IRCCS, Tradate, Italy. Electronic address: giovannibattista.migliori@icsmaugeri.it. LA - eng PT - Journal Article DEP - 20260212 PL - Canada TA - Int J Infect Dis JT - International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases JID - 9610933 SB - IM MH - Humans MH - Bangladesh/epidemiology MH - Female MH - Male MH - Adult MH - Prospective Studies MH - Feasibility Studies MH - Middle Aged MH - Treatment Outcome MH - *Tuberculosis, Pulmonary/rehabilitation/complications MH - Young Adult MH - Forced Expiratory Volume MH - Surveys and Questionnaires MH - Vital Capacity MH - Respiratory Function Tests MH - Adolescent OTO - NOTNLM OT - Efficacy OT - Exercise capacity OT - Lung function OT - Post-TB lung disease OT - Pulmonary rehabilitation OT - TB sequelae COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/02/15 00:31 MHDA- 2026/05/09 00:34 CRDT- 2026/02/14 19:13 PHST- 2026/01/19 00:00 [received] PHST- 2026/02/06 00:00 [revised] PHST- 2026/02/08 00:00 [accepted] PHST- 2026/05/09 00:34 [medline] PHST- 2026/02/15 00:31 [pubmed] PHST- 2026/02/14 19:13 [entrez] AID - S1201-9712(26)00112-8 [pii] AID - 10.1016/j.ijid.2026.108477 [doi] PST - ppublish SO - Int J Infect Dis. 2026 Jun;167:108477. doi: 10.1016/j.ijid.2026.108477. Epub 2026 Feb 12. PMID- 41690196 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1618-131X (Electronic) IS - 1438-4639 (Linking) VI - 273 DP - 2026 Apr TI - Defining the external exposome of newborns from La Palma Island, Spain: characteristics of realistic mixtures and its role on Precision Public Health. PG - 114761 LID - S1438-4639(26)00021-0 [pii] LID - 10.1016/j.ijheh.2026.114761 [doi] AB - INTRODUCTION: The exposome framework provides an integrative perspective to characterize real-life exposures beyond single-chemical assessments. However, evidence on perinatal exposomes in non-urban populations is limited, particularly regarding pollutant mixtures and their contribution to adverse birth outcomes. METHODS: We conducted a population-based cross-sectional study including 471 neonates from La Palma (Spain). A total of 106 pollutants were quantified in cord blood using validated methods. Exposures encompassed essential elements, toxic metals, prioritized pollutants, emerging elements, organochlorine pesticides (OCPs), polychlorinated biphenyls (PCBs), and polycyclic aromatic hydrocarbons (PAHs), grouped into seven categories. Statistical analyses included descriptive statistics, correlation matrices, principal component analysis (PCA), and network visualization, stratified by sex, birthweight, and maternal smoking. RESULTS: Essential elements (Se, Zn, Cu, Mn) were detected in all samples, whereas emerging rare earth elements showed lower prevalence. PCA highlighted distinct exposure profiles, with PAHs and OCPs explaining the highest variance. Maternal smoking strongly influenced clustering: small for gestational age neonates from smoking mothers displayed a specific mixture of PAHs, OCPs, low-chlorinated PCBs, and Pb, contrasting with neonates of appropriate or large for gestational age. Network analyses revealed four main pollutant clusters, diverging from the seven predefined chemical groups and reflecting real-world mixtures shaped by common sources. Emerging pollutants, including rare earth elements and metals from electronic waste, formed a separate cluster. CONCLUSION: Exposome-based approaches can characterize neonatal exposure mixtures, reveal modifiable patterns, and inform targeted interventions within Precision Public Health. These findings underscore the need to mitigate maternal smoking and address emerging contaminant exposures in perinatal populations. CI - Copyright (c) 2026 The Authors. Published by Elsevier GmbH.. All rights reserved. FAU - Santana Del Pino, Angelo AU - Santana Del Pino A AD - Department of Mathematics, Statistics Unit, Universidad de Las Palmas de Gran Canaria, 35016, Spain. FAU - Quintana-Montesdeoca, Maria Del Pino AU - Quintana-Montesdeoca MDP AD - Department of Mathematics, Statistics Unit, Universidad de Las Palmas de Gran Canaria, 35016, Spain; Research Group in Environment and Health, Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016, Las Palmas de Gran Canaria, Spain. FAU - Simbana-Rivera, Katherine AU - Simbana-Rivera K AD - Research Group in Environment and Health, Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016, Las Palmas de Gran Canaria, Spain; Centro de Investigacion para la Salud en America Latina (CISeAL), Facultad de Medicina, Pontificia Universidad Catolica del Ecuador (PUCE), Quito, Ecuador. Electronic address: katherine.simbana@ulpgc.es. FAU - Zumbado, Manuel AU - Zumbado M AD - Research Group in Environment and Health, Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016, Las Palmas de Gran Canaria, Spain; Spanish Biomedical Research Center in Physiopathology of Obesity and Nutrition (CIBERObn), Instituto de Salud Carlos III, Spain. FAU - Luzardo, Octavio P AU - Luzardo OP AD - Research Group in Environment and Health, Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016, Las Palmas de Gran Canaria, Spain; Spanish Biomedical Research Center in Physiopathology of Obesity and Nutrition (CIBERObn), Instituto de Salud Carlos III, Spain. FAU - Henriquez-Hernandez, Luis Alberto AU - Henriquez-Hernandez LA AD - Research Group in Environment and Health, Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016, Las Palmas de Gran Canaria, Spain; Spanish Biomedical Research Center in Physiopathology of Obesity and Nutrition (CIBERObn), Instituto de Salud Carlos III, Spain. FAU - Cabrera-Rodriguez, Raul AU - Cabrera-Rodriguez R AD - Radiology Service. Hospital Universitario de La Palma (HULP), Brena Alta, 38713, La Palma, Spain. FAU - Almeida-Gonzalez, Maira Del Pino AU - Almeida-Gonzalez MDP AD - Research Group in Environment and Health, Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016, Las Palmas de Gran Canaria, Spain; Institute of Legal Medicine of Las Palmas, 35016, Las Palmas de Gran Canaria, Spain. FAU - Boada, Luis D AU - Boada LD AD - Research Group in Environment and Health, Research Institute of Biomedical and Health Sciences (IUIBS), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera s/n, 35016, Las Palmas de Gran Canaria, Spain; Spanish Biomedical Research Center in Physiopathology of Obesity and Nutrition (CIBERObn), Instituto de Salud Carlos III, Spain. LA - eng PT - Journal Article DEP - 20260213 PL - Germany TA - Int J Hyg Environ Health JT - International journal of hygiene and environmental health JID - 100898843 RN - 0 (Environmental Pollutants) RN - 0 (Polycyclic Aromatic Hydrocarbons) RN - DFC2HB4I0K (Polychlorinated Biphenyls) RN - 0 (Hydrocarbons, Chlorinated) RN - 0 (Pesticides) RN - 0 (Metals) SB - IM MH - Humans MH - Spain MH - Infant, Newborn MH - Female MH - *Environmental Pollutants/blood MH - Cross-Sectional Studies MH - Polycyclic Aromatic Hydrocarbons/blood MH - *Exposome MH - Polychlorinated Biphenyls/blood MH - Hydrocarbons, Chlorinated/blood MH - *Fetal Blood/chemistry MH - Male MH - Pregnancy MH - Maternal Exposure MH - Pesticides/blood MH - Birth Weight MH - Adult MH - Public Health MH - Metals/blood MH - Environmental Exposure OTO - NOTNLM OT - Birth weight OT - Exposome OT - Infant OT - Maternal exposure OT - Newborn OT - Tobacco smoke pollution COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/02/15 00:31 MHDA- 2026/03/07 16:14 CRDT- 2026/02/14 18:09 PHST- 2025/10/01 00:00 [received] PHST- 2026/01/28 00:00 [revised] PHST- 2026/02/11 00:00 [accepted] PHST- 2026/03/07 16:14 [medline] PHST- 2026/02/15 00:31 [pubmed] PHST- 2026/02/14 18:09 [entrez] AID - S1438-4639(26)00021-0 [pii] AID - 10.1016/j.ijheh.2026.114761 [doi] PST - ppublish SO - Int J Hyg Environ Health. 2026 Apr;273:114761. doi: 10.1016/j.ijheh.2026.114761. Epub 2026 Feb 13. PMID- 41689222 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 2 DP - 2026 Feb 12 TI - Blood flow restriction during walking training in bilateral cerebral palsy (EMBRIN): a pilot feasibility study protocol. PG - e110636 LID - 10.1136/bmjopen-2025-110636 [doi] LID - e110636 AB - INTRODUCTION: Children with bilateral cerebral palsy (BCP) frequently develop progressive gait impairments driven in part by muscle weakness. Although power training, which involves high-velocity loaded movements, can enhance functional capacity, its substantial physical demands often limit feasibility in this population. Blood flow restriction (BFR) training has emerged as a promising alternative, capable of eliciting comparable physiological benefits while using low-intensity exercise. This study evaluates the feasibility, safety and clinical effects of integrating BFR with treadmill training in children with BCP, an innovative approach that may deliver the advantages of intensive strengthening while reducing physical burden. METHODS AND ANALYSIS: This single-centre pilot study uses a double-baseline design with 13 participants with BCP (Gross Motor Function Classification System II-III), aged 8-18. The protocol consists of a 10-week usual care period followed by a 10-week Blood Flow Restriction Treadmill Training (BFR-TT) intervention, with three sessions per week. Feasibility targets were defined as completion of at least 80% of at least 80% of sessions. Safety is monitored through pain scales and adverse events. Outcomes assess body function (strength, GAITRite), activity (walking speed, walking endurance and motor function) and participation (daily activities), comparing changes between the usual care and BFR-TT periods. ETHICS AND DISSEMINATION: This study was approved by the French Protection of Persons Committee (2024-A00791-46). Results will be published in peer-reviewed journals and presented at international conferences. TRIAL REGISTRATION NUMBER: NCT06533956. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Christiaens, Adelie AU - Christiaens A AUID- ORCID: 0009-0006-5247-8657 AD - Medecine Physique et de Readaptation, CHU d'Angers, Angers, France adelie.christiaens@univ-angers.fr. AD - Universite d'Angers Laboratoire Angevin de Recherche en Ingenierie des Systemes, Angers, France. FAU - Dinomais, Mickael AU - Dinomais M AD - Medecine Physique et de Readaptation, CHU d'Angers, Angers, France. AD - Universite d'Angers Laboratoire Angevin de Recherche en Ingenierie des Systemes, Angers, France. FAU - Gilquin, Valentine AU - Gilquin V AD - Service de Medecine Physique et de Readaptation, CHU Poitiers, Poitiers, France. FAU - Coelho, Anthony AU - Coelho A AD - Medecine Physique et de Readaptation, CHU d'Angers, Angers, France. AD - Medecine Physique et de Readaptation Pediatrique, Les Capucins Readaptation Specialisee et Soins de Longue Duree, Angers, France. FAU - Carcreff, Lena AU - Carcreff L AD - Medecine Physique et de Readaptation, CHU d'Angers, Angers, France. FAU - Loiez, Anthea AU - Loiez A AD - Direction de La Recherche Clinique et de l'Innovation, CHU d'Angers, Angers, France. FAU - Demas, Josselin AU - Demas J AD - Universite d'Angers Laboratoire Angevin de Recherche en Ingenierie des Systemes, Angers, France. AD - Universite d'Angers Faculte de Sante, Angers, France. AD - Centre Hospitalier de Laval Institut de Formation en Masso-Kinesitherapie, Laval, France. LA - eng SI - ClinicalTrials.gov/NCT06533956 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260212 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Blood Flow Restriction Therapy/methods MH - *Cerebral Palsy/physiopathology/rehabilitation MH - *Exercise Therapy/methods MH - Feasibility Studies MH - Pilot Projects MH - *Walking/physiology MH - Clinical Trials as Topic PMC - PMC12911824 OTO - NOTNLM OT - Child OT - Developmental neurology & neurodisability OT - Feasibility Studies OT - Gait OT - REHABILITATION MEDICINE OT - Treadmill Test COIS- Competing interests: None declared. EDAT- 2026/02/14 06:51 MHDA- 2026/02/14 06:52 PMCR- 2026/02/12 CRDT- 2026/02/14 01:00 PHST- 2026/02/14 06:52 [medline] PHST- 2026/02/14 06:51 [pubmed] PHST- 2026/02/14 01:00 [entrez] PHST- 2026/02/12 00:00 [pmc-release] AID - bmjopen-2025-110636 [pii] AID - 10.1136/bmjopen-2025-110636 [doi] PST - epublish SO - BMJ Open. 2026 Feb 12;16(2):e110636. doi: 10.1136/bmjopen-2025-110636. PMID- 41688959 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Feb 13 TI - Adaptation and validation of the neighbourhood environment walkability scale for German-speaking youth (NEWS-Y-G). LID - 10.1186/s12889-026-26590-3 [doi] LID - 709 AB - BACKGROUND: Adolescents' physical activity is related to characteristics of their neighbourhood environment. Understanding this relationship can help identify ways to promote this important health-related behaviour. The Neighbourhood Environment Walkability Scale for Youth (NEWS-Y) is the most prominent questionnaire to measure subjective perceptions on the neighbourhood environment that might have an influence on their physical activity. This study describes the development of the NEWS-Y for German-speaking adolescents (called NEWS-Y-G) and the evaluation of its reliability and validity. METHODS: The NEWS-Y-G was adapted and validated through a five-step process. First, the original NEWS-Y was translated into German using a back-translation technique. Participatory methods were then used to establish content validity by identifying environmental aspects specifically relevant to the German context. Third, ten cognitive interviews with adolescents were conducted for ensuring understandability before piloting the questionnaire with 587 adolescents. Of these, 249 participants completed the questionnaire twice, allowing for a test-retest reliability evaluation of subscales and individual items by using intraclass correlation coefficients (ICCs). Finally, construct validity was tested through correlations among subscales and associations with self-reported physical activity levels of participants. RESULTS: The NEWS-Y-G showed semantic equivalence with the original version. Five items were removed and twelve items were added, resulting in 74 items across the nine subscales: land use mix-diversity, recreational facilities, residential density, land use mix-access, street connectivity, walking/cycling facilities, aesthetics, traffic- and crime safety. The test-retest reliability of subscales (ICC range = 0.81-0.94) and individual items (ICC range = 0.32- 0.94) in the NEWS-Y-G was moderate to almost perfect. Moderate correlations were observed among several NEWS-Y-G subscales. Only two subscales - recreational facilities and aesthetics - showed statistically significant, albeit very weak, associations with self-reported physical activity (both rho = 0.13, p < 0.01), while no significant associations were found for the other seven subscales (rho = -0.08 to 0.03, p > 0.05). CONCLUSION: The NEWS-Y-G questionnaire demonstrated good test-retest reliability and provided preliminary evidence of validity. While this study supports its use in measuring subjective walkability among adolescents, further studies in German-speaking regions are needed to confirm its validity in relation to physical activity, accounting for different mobility types as well as gender and socioeconomic disparities. The NEWS-Y-G is a valuable tool for evaluating the neighbourhood environment's impact on adolescents, providing results that can inform urban planning and research to promote physical activity. FAU - Scheller, Daniel A AU - Scheller DA AD - TUM School of Medicine and Health, Department Health and Sport Sciences, Associate Professorship of Didactics in Sport and Health, Technical University of Munich, Georg-Brauchle-Ring 62, Munich, 80992, Germany. daniel.scheller@tum.de. FAU - Humpe, Andreas AU - Humpe A AD - Munich University of Applied Sciences, Schachenmeierstrasse 35, Munchen, 80636, Germany. FAU - Mess, Filip AU - Mess F AD - TUM School of Medicine and Health, Department Health and Sport Sciences, Associate Professorship of Didactics in Sport and Health, Technical University of Munich, Georg-Brauchle-Ring 62, Munich, 80992, Germany. FAU - Nogueira de Zorzi, Viviane AU - Nogueira de Zorzi V AD - Postgraduation Program in Physical Education, Federal University of Santa Catarina, Street Eng. Agronomico Andrei Cristian Ferreira, Trindade, Florianopolis, 88040-900, Brazil. FAU - Rech, Cassiano Ricardo AU - Rech CR AD - Postgraduation Program in Physical Education, Federal University of Santa Catarina, Street Eng. Agronomico Andrei Cristian Ferreira, Trindade, Florianopolis, 88040-900, Brazil. FAU - Bachner, Joachim AU - Bachner J AD - TUM School of Medicine and Health, Department Health and Sport Sciences, Associate Professorship of Didactics in Sport and Health, Technical University of Munich, Georg-Brauchle-Ring 62, Munich, 80992, Germany. LA - eng PT - Journal Article PT - Validation Study DEP - 20260213 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Walking/statistics & numerical data MH - Male MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Germany MH - *Environment Design MH - *Residence Characteristics/statistics & numerical data MH - *Neighborhood Characteristics/statistics & numerical data PMC - PMC12931025 OTO - NOTNLM OT - Adolescents OT - Environment OT - Neighbourhood OT - Perception OT - Physical activity OT - Questionnaire OT - Reliability OT - Urban planning OT - Validity OT - Walkability COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of the Technical University of Munich, Germany (reference number 77/22 S). Written informed consent was obtained from both a parent/legal guardian and the participant throughout all data collection phases (including both the interviews and questionnaires). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/14 05:30 MHDA- 2026/06/27 06:44 PMCR- 2026/02/13 CRDT- 2026/02/13 23:58 PHST- 2024/08/07 00:00 [received] PHST- 2026/02/04 00:00 [accepted] PHST- 2026/06/27 06:44 [medline] PHST- 2026/02/14 05:30 [pubmed] PHST- 2026/02/13 23:58 [entrez] PHST- 2026/02/13 00:00 [pmc-release] AID - 10.1186/s12889-026-26590-3 [pii] AID - 26590 [pii] AID - 10.1186/s12889-026-26590-3 [doi] PST - epublish SO - BMC Public Health. 2026 Feb 13;26(1):709. doi: 10.1186/s12889-026-26590-3. PMID- 41688664 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Feb 14 TI - Determinants of food choices on online food delivery applications among university students: a cross-sectional study. LID - 10.1038/s41598-026-40145-x [doi] LID - 9114 AB - The rapid expansion of online food delivery applications (OFDAs) has substantially influenced dietary behaviors among university students. This study examined factors associated with food choices, perceptions of healthy meals, and attitudes toward food safety among OFDAs users at King Khalid University. A cross-sectional survey was conducted among 397 students using a validated online questionnaire. Fast food was the most frequently ordered meal (72.0%), and price was the primary determinant of food choice. Male students were more likely than female students to select healthier options, and healthy food selection differed significantly by body mass index, with the highest proportion among students with obesity. Binary logistic regression showed that price (OR = 2.085), food appearance (OR = 1.487), and perceiving a healthy meal as containing a variety of vegetables (OR = 1.492) were significant predictors of healthy meal selection. Food safety perceptions were significantly associated with meal temperature and packaging, with meal temperature commonly reported as an indicator of food quality and safety. These findings suggest that food choices among OFDA users are associated with multiple factors and may inform efforts to improve the affordability, nutritional quality, visual appeal, and safety of meal options in digital food environments. FAU - Alshahry, Abduraheem Mohammad AU - Alshahry AM AD - Kidney Care Center, Aseer Health Cluster, Ministry of Health, Khamis Mushait, Saudi Arabia. FAU - Alhazmi, Amani AU - Alhazmi A AUID- ORCID: 0000-0002-4062-1640 AD - Public Health Department, Applied Medical Sciences College, King Khalid University, Abha, Saudi Arabia. Amanialhazmi@kku.edu.sa. LA - eng GR - RGP.1/150/46/Deanship of Scientific Research, King Khalid University/ PT - Journal Article DEP - 20260214 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Male MH - Female MH - Cross-Sectional Studies MH - *Students/psychology MH - Universities MH - *Food Preferences/psychology MH - Young Adult MH - *Choice Behavior MH - Surveys and Questionnaires MH - Adult MH - Adolescent MH - Food Safety MH - Fast Foods MH - Body Mass Index PMC - PMC12996546 OTO - NOTNLM OT - Body mass index OT - Diet OT - Food safety OT - Food services OT - Healthy OT - Students COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/02/14 05:31 MHDA- 2026/06/27 06:45 PMCR- 2026/02/14 CRDT- 2026/02/13 23:28 PHST- 2025/10/24 00:00 [received] PHST- 2026/02/10 00:00 [accepted] PHST- 2026/06/27 06:45 [medline] PHST- 2026/02/14 05:31 [pubmed] PHST- 2026/02/13 23:28 [entrez] PHST- 2026/02/14 00:00 [pmc-release] AID - 10.1038/s41598-026-40145-x [pii] AID - 40145 [pii] AID - 10.1038/s41598-026-40145-x [doi] PST - epublish SO - Sci Rep. 2026 Feb 14;16(1):9114. doi: 10.1038/s41598-026-40145-x. PMID- 41688123 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 2 DP - 2026 Feb 12 TI - Is intensive behavioural change enhanced with dialectical behavioural therapy feasible for weight management in adolescents living with higher body weight? A protocol for a pilot randomised controlled trial in three centres in Canada. PG - e106645 LID - 10.1136/bmjopen-2025-106645 [doi] LID - e106645 AB - INTRODUCTION: For adolescents living with higher body weight, changing lifestyle behaviours can be met with challenges due to psychosocial factors, such as mental health and emotional challenges. Few behavioural interventions have included skill development to manage these mental health and emotional challenges. METHODS AND ANALYSIS: The feasibility of a dialectical behavioural therapy (DBT)-enhanced lifestyle intervention will be evaluated through a pilot randomised controlled trial. We will recruit 90 adolescents aged 14-17 years with a body mass index Z-score >1.4 and mild-to-moderate depressive symptoms to participate with a caregiver in the trial. Adolescents will be randomised 2:2:1 to one of the three study arms: (A) behavioural lifestyle intervention with DBT skills training, (B) behavioural lifestyle intervention alone (ie, without DBT skills training) or (C) control. The interventions will include two sessions weekly for 16 weeks that include (1) one modified DBT skills training with two facilitators, supervised by a clinical psychologist, combined with one behavioural lifestyle session delivered by a dietitian and/or a kinesiologist and (2) two behavioural lifestyle sessions alone. DBT skills training will consist of teaching mindfulness, emotion regulation, distress tolerance, interpersonal effectiveness and walking the middle path modules. Behavioural sessions will be guided by evidence-based practices for goal setting, dietary counselling, improving sleep, reducing screen time and structured physical activity. The main outcomes are enrolment rates, adherence to the intervention and retention rates for follow-up measurements. The secondary outcome will be changes in the quality of life (Pediatric Quality of Life Inventory) and daily physical activity levels between baseline and immediately post-intervention. Adolescents will participate in a focus group incorporating photo elicitation to explore satisfaction, acceptability and perceived benefits of the study arms. ETHICS AND DISSEMINATION: This study has received ethical approval from the University of Manitoba's Biomedical Research Ethics Committee (HS24295-H2020:427), Hamilton Health Sciences & McMaster University (HiREB 18159) and The Conjoint Health Research Ethics Board (CHREB), University of Calgary (REB24-1084). Results will be disseminated through publication in peer-reviewed journals and be relevant to researchers and clinicians involved in paediatrics and paediatric weight management. TRIAL REGISTRATION NUMBER: NCT05338944. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Cameron, Emily E AU - Cameron EE AD - Faculty of Education, Simon Fraser University, Burnaby, British Columbia, Canada. AD - BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada. FAU - Morrison, Katherine M AU - Morrison KM AUID- ORCID: 0000-0002-1737-256X AD - Department of Pediatrics, Centre for Metabolism, Obesity and Diabetes Research Health, McMaster University, Hamilton, Ontario, Canada. FAU - Ho, Josephine AU - Ho J AD - Department of Pediatrics, Cumming School of Medicine, Alberta Children's Hospital, Calgary, Alberta, Canada. FAU - Roos, Leslie AU - Roos L AD - University of Manitoba Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada. AD - Department of Psychology, University of Manitoba Faculty of Arts, Winnipeg, Manitoba, Canada. FAU - Katz, Laurence AU - Katz L AD - Psychiatry, University of Manitoba Faculty of Health Sciences, Winnipeg, Manitoba, Canada. FAU - Mushquash, Aislin AU - Mushquash A AD - Department of Psychology, Lakehead University, Thunder Bay, Ontario, Canada. FAU - Dart, Allison AU - Dart A AD - University of Manitoba Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada. AD - Pediatrics, University of Manitoba Faculty of Health Sciences, Winnipeg, Manitoba, Canada. FAU - Wicklow, Brandy A AU - Wicklow BA AD - University of Manitoba Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada. AD - Pediatrics, University of Manitoba Faculty of Health Sciences, Winnipeg, Manitoba, Canada. FAU - Senechal, Martin AU - Senechal M AD - Faculty of Kinesiology, University of New Brunswick Faculty of Science, Fredericton, New Brunswick, Canada. FAU - Jung, Mary E AU - Jung ME AUID- ORCID: 0000-0002-2360-0952 AD - School of Health and Exercise Sciences, The University of British Columbia, Kelowna, British Columbia, Canada. FAU - Strachan, Shaelyn M AU - Strachan SM AD - Faculty of Kinesiology and Recreation Management, University of Manitoba, Winnipeg, Manitoba, Canada. FAU - Afifi, Tracie O AU - Afifi TO AD - Community Health Sciences, University of Manitoba College of Medicine, Winnipeg, Manitoba, Canada. FAU - Archibald, Mandy AU - Archibald M AUID- ORCID: 0000-0003-4767-1031 AD - University of Manitoba Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada. AD - College of Nursing, University of Manitoba, Winnipeg, Manitoba, Canada. FAU - Andrade, Brendan AU - Andrade B AD - Margaret and Wallace McCain Centre for Child Youth and Family Mental Health, Centre for Addiction and Mental Health, University of Toronto Department of Psychiatry, Toronto, Ontario, Canada. FAU - Hadjiyannakis, Stasia AU - Hadjiyannakis S AD - Children's Hospital of Eastern Ontario Research Institute, Ottawa, Ontario, Canada. AD - Division of Endocrinology and Metabolism, University of Ottawa, Ottawa, Ontario, Canada. FAU - Hamilton, Jill AU - Hamilton J AUID- ORCID: 0000-0002-1958-2800 AD - The Hospital for Sick Children Department of Paediatrics, Toronto, Ontario, Canada. FAU - Slaght, Jana AU - Slaght J AD - University of Manitoba Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada. AD - Pediatrics, University of Manitoba Faculty of Health Sciences, Winnipeg, Manitoba, Canada. FAU - Penner, Kailey AU - Penner K AD - University of Manitoba Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada. AD - Department of Psychology, University of Manitoba Faculty of Arts, Winnipeg, Manitoba, Canada. FAU - Balshaw, Robert F AU - Balshaw RF AUID- ORCID: 0000-0002-2455-8792 AD - Community Health Sciences, University of Manitoba College of Medicine, Winnipeg, Manitoba, Canada. FAU - McGavock, Jonathan AU - McGavock J AUID- ORCID: 0000-0002-3741-5248 AD - University of Manitoba Children's Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada jmcgavock@chrim.ca. AD - Pediatrics, University of Manitoba Faculty of Health Sciences, Winnipeg, Manitoba, Canada. LA - eng SI - ClinicalTrials.gov/NCT05338944 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260212 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Adolescent MH - Pilot Projects MH - Female MH - *Dialectical Behavior Therapy/methods MH - Feasibility Studies MH - Randomized Controlled Trials as Topic MH - Canada MH - *Pediatric Obesity/therapy/psychology MH - Male MH - Life Style MH - Body Weight MH - Body Mass Index PMC - PMC12911816 OTO - NOTNLM OT - Exercise OT - NUTRITION & DIETETICS OT - Obesity OT - PAEDIATRICS OT - Stress, Psychological COIS- Competing interests: None declared. EDAT- 2026/02/14 05:30 MHDA- 2026/02/14 05:31 PMCR- 2026/02/12 CRDT- 2026/02/13 20:43 PHST- 2026/02/14 05:31 [medline] PHST- 2026/02/14 05:30 [pubmed] PHST- 2026/02/13 20:43 [entrez] PHST- 2026/02/12 00:00 [pmc-release] AID - bmjopen-2025-106645 [pii] AID - 10.1136/bmjopen-2025-106645 [doi] PST - epublish SO - BMJ Open. 2026 Feb 12;16(2):e106645. doi: 10.1136/bmjopen-2025-106645. PMID- 41687326 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1873-6807 (Electronic) IS - 1740-1445 (Linking) VI - 56 DP - 2026 Mar TI - The Body Acceptance by Others Scale-2: An examination of its psychometric properties in a French-Canadian adult sample. PG - 102045 LID - S1740-1445(26)00016-1 [pii] LID - 10.1016/j.bodyim.2026.102045 [doi] AB - The 13-item Body Acceptance by Others Scale-2 (BAOS-2) is an instrument designed to measure generalised perceptions of body acceptance by others. Here, we examined the psychometric properties of a novel French translation of the BAOS-2. A total of 763 French-speaking adults from Canada were asked to complete the BAOS-2, alongside additional validated measures of positive body image, psychological well-being, and eating patterns. Exploratory factor analysis in a first split-half subsample (n = 382) indicated that a unidimensional model with all 13 items had good fit to the data. This model was cross-validated in a second split-half subsample (n = 381) using confirmatory factor analysis. A partial factors-only model indicated, as a function of subsamples, that the French BAOS-2 has differential item functioning based on respondent age, body mass index (BMI), and gender identity (men, women). In addition, higher respondent BMI was associated with lower body acceptance in both subsamples. Our results also supported convergent and concurrent validity of the French BAOS-2, with body acceptance by others associated with greater body appreciation and psychological well-being, as well as lower symptoms of maladaptive eating patterns. The present results indicate that the French BAOS-2 has strong psychometric properties in French-speaking Canadian adults. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Maiano, Christophe AU - Maiano C AD - Cyberpsychology Laboratory and Department of Psychoeducation and Psychology, Universite du Quebec en Outaouais (UQO|Campus de Saint-Jerome), Saint-Jerome, Canada; Substantive-Methodological Synergy Research Laboratory, Department of Psychology, Concordia University, Montreal, Canada. Electronic address: christophe.maiano@uqo.ca. FAU - Swami, Viren AU - Swami V AD - School of Psychology, Sport, and Sensory Sciences, Anglia Ruskin University, Cambridge, United Kingdom; Centre for Psychological Medicine, Perdana University, Kuala Lumpur, Malaysia. FAU - Tylka, Tracy L AU - Tylka TL AD - Department of Psychology, The Ohio State University, Columbus, OH, USA. FAU - Aime, Annie AU - Aime A AD - Cyberpsychology Laboratory and Department of Psychoeducation and Psychology, Universite du Quebec en Outaouais (UQO|Campus de Saint-Jerome), Saint-Jerome, Canada. LA - eng PT - Journal Article DEP - 20260212 PL - Netherlands TA - Body Image JT - Body image JID - 101222431 SB - IM MH - Humans MH - Female MH - Psychometrics MH - Male MH - Adult MH - *Body Image/psychology MH - Canada MH - Reproducibility of Results MH - Body Satisfaction MH - Body Mass Index MH - Middle Aged MH - Young Adult MH - Surveys and Questionnaires/standards MH - Psychological Well-Being MH - Adolescent OTO - NOTNLM OT - Body acceptance by others OT - Canada OT - French OT - Positive body image OT - Psychometrics OT - Test adaptation COIS- Declaration of competing interest The authors declare they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper . Given her role as Editor-in-Chief of Body Image, Tracy L. Tylka had no involvement in the peer review of this article and had no access to information regarding its peer review. Full responsibility for the editorial process for this article was delegated to another journal editor. EDAT- 2026/02/14 05:30 MHDA- 2026/03/06 09:11 CRDT- 2026/02/13 18:06 PHST- 2025/09/26 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/02/06 00:00 [accepted] PHST- 2026/03/06 09:11 [medline] PHST- 2026/02/14 05:30 [pubmed] PHST- 2026/02/13 18:06 [entrez] AID - S1740-1445(26)00016-1 [pii] AID - 10.1016/j.bodyim.2026.102045 [doi] PST - ppublish SO - Body Image. 2026 Mar;56:102045. doi: 10.1016/j.bodyim.2026.102045. Epub 2026 Feb 12. PMID- 41686762 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260213 LR - 20260216 IS - 2767-3375 (Electronic) IS - 2767-3375 (Linking) VI - 6 IP - 2 DP - 2026 TI - Infant HIV-protection: Comparing antiretroviral therapy, maternal and infant factors influence on infant HIV acquisition in Uganda: A six-year real-world experience. PG - e0004896 LID - 10.1371/journal.pgph.0004896 [doi] LID - e0004896 AB - Although antiretroviral therapy (ART) scale up has markedly lowered vertical transmission, the relative contribution of ART regimens, maternal factors, and infant practices within Prevention of vertical transmission (PVT) programs is not fully understood. We assessed the comparative influence of maternal and infant factors on infant HIV positivity. We retrospectively reviewed records of 962 HIV exposed infants attending the Mildmay Uganda PVT clinic between 2018 and 2023. Of these, 918 were mother-infant pairs. Descriptive statistics summarised maternal and infant characteristics. Associations were assessed using Chi square or Fisher exact tests. Two independent logistic regression models identified infant and maternal factors associated with HIV positivity. Pseudo R(2) evaluated model performance and area under the curve measured discrimination. Among 918 mother-infant pairs, HIV positivity was 1.96% (18). PI based regimens were associated with increased odds of HIV positivity (aOR 22.89, 95% CI 2.20-238.14, p = 0.009). Among maternal factors, HIV positivity differed significantly by age group (p < 0.001) and viral load suppression status (p = 0.025), with viral load non-suppression independently increasing risk (aOR 4.97, 95% CI 1.45-17.10, p = 0.011). Among infant factors, mixed feeding (aOR 26.87, 95% CI 5.82-124.10) and no breastfeeding (aOR 86.94, 95%CI 17.40-434.56) were strongly associated with HIV positivity (both p < 0.001). The maternal model showed modest explanatory capacity (pseudo R(2) 0.09) and acceptable discrimination (AUC 0.74; bootstrap AUC 0.70, 95% CI 0.58-0.83). The infant model demonstrated stronger performance (pseudo R(2) 0.51) with excellent discrimination (AUC 0.94; cross-validated AUC 0.95, 95% CI 0.79-0.95).While maternal ART regimen and viral suppression are critical, infant feeding practices appear to have a stronger influence on infant HIV positivity. Strengthening counselling on optimal infant feeding practices and timely HIV prophylaxis is essential to achieve elimination of paediatric HIV. CI - Copyright: (c) 2026 Ankunda et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Ankunda, Collins AU - Ankunda C AUID- ORCID: 0000-0003-2130-4014 AD - Department of Pharmacology and Therapeutics, Makerere University, Kampala Uganda. AD - Department of Global Public health, Karolinska Institute, Stockholm, Sweden. AD - Mildmay Uganda Research Centre, Naziba Hill, Kampala, Uganda. FAU - Emunyu, Jude AU - Emunyu J AD - Makerere University Walter Reed Program, Kampala, Uganda. FAU - Kyomuhangi, Brendah AU - Kyomuhangi B AD - Entebbe Regional Referral Hospital, Entebbe, Uganda. FAU - Namasambi, Sharon AU - Namasambi S AD - Uganda Public Health Fellowship Program, Uganda National Institute of Public Health, Kampala, Uganda. FAU - Sserunjogi, Conrad AU - Sserunjogi C AUID- ORCID: 0009-0003-9900-9776 AD - Mildmay Uganda Research Centre, Naziba Hill, Kampala, Uganda. FAU - Mumbere, Iving AU - Mumbere I AD - School of Public Health, Makerere University, Kampala, Uganda. FAU - Nakaweesi, Jane AU - Nakaweesi J AD - Baylor College of Medicine Children's Foundation, Kampala, Uganda. LA - eng PT - Journal Article DEP - 20260213 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC12904416 COIS- The authors have declared that no competing interests exist. EDAT- 2026/02/13 19:07 MHDA- 2026/02/13 19:08 PMCR- 2026/02/13 CRDT- 2026/02/13 13:33 PHST- 2025/06/23 00:00 [received] PHST- 2026/01/26 00:00 [accepted] PHST- 2026/02/13 19:08 [medline] PHST- 2026/02/13 19:07 [pubmed] PHST- 2026/02/13 13:33 [entrez] PHST- 2026/02/13 00:00 [pmc-release] AID - PGPH-D-25-01533 [pii] AID - 10.1371/journal.pgph.0004896 [doi] PST - epublish SO - PLOS Glob Public Health. 2026 Feb 13;6(2):e0004896. doi: 10.1371/journal.pgph.0004896. eCollection 2026. PMID- 41685777 OWN - NLM STAT- MEDLINE DCOM- 20260828 LR - 20260828 IS - 1748-3115 (Electronic) IS - 1748-3107 (Linking) VI - 21 IP - 6 DP - 2026 Aug TI - Knowledge, attitudes, and practices of New Zealand council members when developing accessible public playgrounds for children of all abilities. PG - 2532-2547 LID - 10.1080/17483107.2026.2628320 [doi] AB - Unstructured or "free play" is essential for children's psychological, emotional, social, and physical development. For disabled children, accessible playgrounds function as assistive environments that enable participation and inclusion. However, many playgrounds remain inaccessible due to limited awareness of inclusive design among those responsible for planning and development. This study explored the knowledge, practices, and perceived barriers among New Zealand local councils in the context of accessible playground design. All 78 councils, across 23 regions, were invited to complete an online questionnaire examining stakeholder involvement, current and desired knowledge, perceived importance of design features, and barriers to accessibility. Twenty-nine councils (37.2%), representing 17 regions, participated. All respondents reported public consultation in the design process, and most (93%) involved specific external groups. Key barriers to inclusive design included funding constraints, limited awareness or expertise, challenges sourcing suitable equipment, and space limitations. While many council staff believed they understood accessibility needs, they identified a lack of knowledge among contractors and other departments. These findings highlight the role of inclusive playgrounds as assistive infrastructure that promotes participation for disabled children. There is a clear need for targeted training and the development of research-informed, standardised design guidelines to support universal design practices. Such resources could improve both the financial feasibility and inclusivity of playgrounds. Participants also stressed the importance of prioritising social inclusion and wellbeing alongside physical and environmental considerations in future playground planning. FAU - Belcher, Suzanne AU - Belcher S AUID- ORCID: 0000-0001-8479-540X AD - Physiotherapy Department, Centre for Health and Social Practice, Waikato Institute of Technology (Wintec), Hamilton, New Zealand. AD - Master of Physiotherapy Practice, School of Exercise, Sport and Rehabilitation Sciences, The University of Auckland, Auckland, New Zealand. FAU - Crump, Nicole AU - Crump N AD - Physiotherapy Department, Centre for Health and Social Practice, Waikato Institute of Technology (Wintec), Hamilton, New Zealand. AD - Proactive Rehab, Papamoa, Tauranga, New Zealand. FAU - Perry, Meredith AU - Perry M AUID- ORCID: 0000-0003-1602-4421 AD - Centre of Health Activity and Rehabilitation Research, School of Physiotherapy, University of Otago, Dunedin, New Zealand. FAU - Sampath, Kesava Kovanur AU - Sampath KK AUID- ORCID: 0000-0001-9908-3659 AD - Physiotherapy Department, Centre for Health and Social Practice, Waikato Institute of Technology (Wintec), Hamilton, New Zealand. AD - Osteopathy, School of Health and Biomedical Sciences, STEM College, RMIT University, Melbourne, Australia. LA - eng PT - Journal Article DEP - 20260213 PL - England TA - Disabil Rehabil Assist Technol JT - Disability and rehabilitation. Assistive technology JID - 101255937 SB - IM MH - Humans MH - New Zealand MH - *Play and Playthings MH - Child MH - *Children with Disabilities/rehabilitation MH - *Architectural Accessibility MH - Surveys and Questionnaires MH - *Health Knowledge, Attitudes, Practice MH - *Environment Design OAB - Access to playgrounds for all children is essential to allow equal opportunities for child physical, psychological, emotional, spiritual, and social wellbeing and risk perception development.Inclusive play environments function as a form of assistive technology for children with disabilities, supporting improved motor coordination, joint mobility, aerobic fitness and strength.Developing standardised reference designs for external developers could improve the creation of financially viable user-friendly playground, offering greater opportunities for effective engagement, development and rehabilitative prospects for children with and without disabilities.Playground development planning should consider equal emphasis on social inclusion and wellness, alongside physical and environmental determinants, to increase equitable accessibility and meet al.l physical and psychosocial needs for all children. OABL- eng OTO - NOTNLM OT - Disability OT - council policy OT - design OT - free play OT - play spaces OT - social inclusion EDAT- 2026/02/13 12:50 MHDA- 2026/08/28 18:07 CRDT- 2026/02/13 08:03 PHST- 2026/08/28 18:07 [medline] PHST- 2026/02/13 12:50 [pubmed] PHST- 2026/02/13 08:03 [entrez] AID - 10.1080/17483107.2026.2628320 [doi] PST - ppublish SO - Disabil Rehabil Assist Technol. 2026 Aug;21(6):2532-2547. doi: 10.1080/17483107.2026.2628320. Epub 2026 Feb 13. PMID- 41685224 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260213 LR - 20260215 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Mechanisms through which table tennis practice influences the development of big five personality traits in primary school students. PG - 1705050 LID - 10.3389/fpsyg.2026.1705050 [doi] LID - 1705050 AB - This quasi-experimental study examined the effects of a 16-week systematic table tennis training program on the Big Five personality traits of primary school students. Previous research has largely focused on the macro-level effects of physical activity, with limited fine-grained investigation into the psychological shaping mechanisms of specific sports, particularly intervention-based evidence involving children without prior training. A total of 98 male students aged 9-10 years were enrolled and, after propensity score matching (including age, baseline personality scores, etc.), were allocated to an experimental group (n = 49) or a control group (n = 49). The experimental group received moderate-intensity table tennis training three times per week (120 min per session), comprising technical drills, tactical exercises, and match simulations, while the control group maintained their routine activities. The short-form NEO Five-Factor Inventory (NEO-FFI) was administered before and after the intervention. A 2 x 2 mixed-design ANOVA and analysis of covariance (ANCOVA), with pretest scores as covariates, were used to analyze the effects. The results revealed significant Time x Group interaction effects for Openness (F(1,92) = 64.32, p < 0.001, eta (2) = 0.411), Neuroticism (F(1,92) = 42.18, p < 0.001, eta (2) = 0.314), Agreeableness (F(1,92) = 89.45, p < 0.001, eta (2) = 0.493), and Extraversion (F(1,92) = 56.74, p < 0.001, eta (2) = 0.381) but not for Conscientiousness (p = 0.076). Simple effects analyses indicated that the experimental group showed significant post-intervention improvements in Openness (d = 1.67), Agreeableness (d = 1.56), and Extraversion (d = 0.86), along with a significant reduction in Neuroticism (d = -0.89). No significant changes were observed in the control group. The findings suggest that systematic table tennis training can effectively promote the development of emotional stability, openness, agreeableness, and extraversion in primary school students, but it has a limited effect on conscientiousness. This study provides preliminary causal evidence for fostering children's personality development through a specific sport and offers empirical support for the integration of sports and education. Limitations include the all-male sample and the quasi-experimental design. Future research should employ large-scale randomized controlled trials and multi-source assessments to further validate these results. CI - Copyright (c) 2026 Wang, Zou, Du, Chen and Huang. FAU - Wang, Jian AU - Wang J AD - School of Physical Education and Health, East China Jiaotong University, Nanchang, China. FAU - Zou, Yating AU - Zou Y AD - College of Education, Nanchang Vocational University, Nanchang, China. FAU - Du, Liping AU - Du L AD - School of Physical Education, Xichang University, Xichang, China. FAU - Chen, Yang AU - Chen Y AD - School of Physical Education, Xi'an Jiaotong University, Xi'an, China. FAU - Huang, Guoyuan AU - Huang G AD - College of Physical Education, Sichuan Agricultural University, Ya'an, China. LA - eng PT - Journal Article DEP - 20260128 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12892341 OTO - NOTNLM OT - big five personality traits OT - exercise intervention OT - primary school students OT - psychology OT - table tennis COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/13 06:33 MHDA- 2026/02/13 06:34 PMCR- 2026/01/28 CRDT- 2026/02/13 04:33 PHST- 2025/09/14 00:00 [received] PHST- 2025/12/30 00:00 [revised] PHST- 2026/01/12 00:00 [accepted] PHST- 2026/02/13 06:34 [medline] PHST- 2026/02/13 06:33 [pubmed] PHST- 2026/02/13 04:33 [entrez] PHST- 2026/01/28 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1705050 [doi] PST - epublish SO - Front Psychol. 2026 Jan 28;17:1705050. doi: 10.3389/fpsyg.2026.1705050. eCollection 2026. PMID- 41685214 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260213 LR - 20260215 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 17 DP - 2026 TI - Green exercise and kinesiophobia among Chinese adolescents: the mediating role of self-efficacy. PG - 1743182 LID - 10.3389/fpsyg.2026.1743182 [doi] LID - 1743182 AB - OBJECTIVE: Kinesiophobia is a common psychological barrier to physical activity during adolescence and is characterized by fear-related attention to bodily sensations and avoidance of movement. This study examined whether green exercise is associated with lower kinesiophobia among adolescents and whether self-efficacy statistically mediates these associations, drawing on social cognitive theory. METHODS: A cross-sectional questionnaire survey was conducted among 1,099 Chinese students in Grades 5-9 (aged 10-15 years); adolescents. Participants completed validated self-report measures of green exercise (5 items), self-efficacy (10 items), and kinesiophobia (13 items; somatic focus and activity avoidance). Descriptive statistics, multiple regression (controlling for gender, grade, and place of residence), structural equation modeling (SEM), and bias-corrected bootstrap tests (5,000 resamples) were used to evaluate the hypothesized relationships. RESULTS: In multiple regression analyses, green exercise (beta = -0.217; beta = -0.289) and self-efficacy (beta = -0.279; beta = -0.266) were significant negative predictors of somatic focus and activity avoidance, respectively (all p < 0.001), with modest explained variance (R (2) = 0.194 and 0.232). In SEM, green exercise was positively associated with self-efficacy (beta = 0.351, p < 0.001) and showed significant direct associations with somatic focus (beta = -0.251, p < 0.001) and activity avoidance (beta = -0.315, p < 0.001). Self-efficacy was negatively associated with somatic focus (beta = -0.308, p < 0.001) and activity avoidance (beta = -0.299, p < 0.001). Bootstrap analyses supported partial indirect effects via self-efficacy for somatic focus (beta = -0.108; 30.08% of total effect) and activity avoidance (beta = -0.105; 25.00% of total effect). CONCLUSION: Findings indicate that greater participation in green exercise is associated with lower kinesiophobia in adolescents, partly through higher self-efficacy. The pattern is consistent with a social-cognitive mechanism linking outdoor physical activity to fear-related responses to movement, while causal inferences require longitudinal or experimental research. CI - Copyright (c) 2026 Kong, Ren, Liu and Yin. FAU - Kong, Mingmin AU - Kong M AD - School of Sports Training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Ren, Yawei AU - Ren Y AD - School of Sports Training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Liu, Tong AU - Liu T AD - School of Sports Training, Chengdu Sport University, Chengdu, Sichuan, China. FAU - Yin, Zhonggen AU - Yin Z AD - College of Physical Education and Health Management, Chongqing University of Education, Chongqing, China. LA - eng PT - Journal Article DEP - 20260128 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12891208 OTO - NOTNLM OT - activity avoidance OT - adolescents OT - green exercise OT - kinesiophobia OT - self-efficacy OT - social cognitive theory OT - somatic focus COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/13 06:32 MHDA- 2026/02/13 06:33 PMCR- 2026/01/28 CRDT- 2026/02/13 04:33 PHST- 2025/11/10 00:00 [received] PHST- 2025/12/23 00:00 [revised] PHST- 2026/01/09 00:00 [accepted] PHST- 2026/02/13 06:33 [medline] PHST- 2026/02/13 06:32 [pubmed] PHST- 2026/02/13 04:33 [entrez] PHST- 2026/01/28 00:00 [pmc-release] AID - 10.3389/fpsyg.2026.1743182 [doi] PST - epublish SO - Front Psychol. 2026 Jan 28;17:1743182. doi: 10.3389/fpsyg.2026.1743182. eCollection 2026. PMID- 41685062 OWN - NLM STAT- Publisher LR - 20260920 IS - 1520-9210 (Print) IS - 1941-0077 (Electronic) IS - 1520-9210 (Linking) DP - 2026 Feb 10 TI - Screen Detection from Egocentric Image Streams Leveraging Multi-View Vision Language Model. LID - 10.1109/tmm.2026.3660180 [doi] AB - Accurately monitoring the screen exposure of young children is important for research related to screen use, such as childhood obesity, physical activity, and social interaction. Most existing studies rely upon self-report or manual measures from bulky wearable sensors, thus lacking efficiency and accuracy in capturing quantitative screen exposure data. In this work, we developed a novel screen detection framework that utilizes egocentric images from a wearable sensor, named the screen time tracker (STT), and a vision language model (VLM). In particular, we devised a multi-view VLM that takes multiple views from egocentric image streams and interprets screen exposure dynamically. We validated our approach by using a dataset of children's free-living activities, demonstrating significant improvement over existing methods in conventional vision language models and object detection models. The combination of a vision language model and a lightweight hardware design provides a novel solution in screen detection for children. The proposed framework has great potential to benefit children's behavioral study. The code is available at https://github.com/YGanLab/MV-VLM. FAU - Li, Xueshen AU - Li X AD - Department of Biomedical Engineering, Stevens Institute of Technology. FAU - Shen, Sen AU - Shen S AD - Department of Computer Science, Iowa State University. FAU - Hou, Xinlong AU - Hou X AD - Department of Biomedical Engineering, Stevens Institute of Technology. FAU - Gao, Xinran AU - Gao X AD - Department of Biomedical Engineering, Stevens Institute of Technology. FAU - Huang, Ziyi AU - Huang Z AD - School of Biological and Health Systems Engineering, Arizona State University. FAU - Holiday, Steven J AU - Holiday SJ AD - Department of Communication & Information Science, University of Alabama. FAU - Cribbet, Matthew R AU - Cribbet MR AD - Department of Psychology, University of Alabama. FAU - White, Susan W AU - White SW AD - Department of Psychology, University of Alabama. FAU - Sazonov, Edward AU - Sazonov E AD - Department of Electrical and Computer Engineering, University of Alabama. FAU - Gan, Yu AU - Gan Y AD - Department of Biomedical Engineering, Stevens Institute of Technology. LA - eng GR - R21 HD104164/HD/NICHD NIH HHS/United States GR - R21 HD112773/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20260210 PL - United States TA - IEEE Trans Multimedia JT - IEEE transactions on multimedia JID - 101210915 PMC - PMC12893618 MID - NIHMS2123918 OTO - NOTNLM OT - Egocentric Image Streams OT - Vision Language Model OT - Wearable Sensor EDAT- 2026/02/13 06:32 MHDA- 2026/02/13 06:32 PMCR- 2026/02/12 CRDT- 2026/02/13 04:31 PHST- 2026/02/13 06:32 [medline] PHST- 2026/02/13 06:32 [pubmed] PHST- 2026/02/13 04:31 [entrez] PHST- 2026/02/12 00:00 [pmc-release] AID - 10.1109/tmm.2026.3660180 [doi] PST - aheadofprint SO - IEEE Trans Multimedia. 2026 Feb 10:10.1109/tmm.2026.3660180. doi: 10.1109/tmm.2026.3660180. PMID- 41684797 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260213 LR - 20260215 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 17 DP - 2026 TI - Latent profiles of post-traumatic distress and growth in adolescents: the role of modifiable protective factors. PG - 1720487 LID - 10.3389/fpsyt.2026.1720487 [doi] LID - 1720487 AB - OBJECTIVE: This study examined heterogeneous patterns of trauma-related adaptation among Chinese adolescents during the post-COVID-19 recovery phase, focusing on the co-occurrence of posttraumatic distress (PTD) and posttraumatic growth (PTG). We also investigated how modifiable psychosocial protective and vulnerability factors were associated with membership in different adaptation profiles. METHOD: A large-scale cross-sectional survey was administered to 5, 044 students (aged 9-17 years; 46.6% male) from 15 primary and secondary schools in Wuhan, China. Validated instruments assessed posttraumatic stress symptoms (PCL-C), posttraumatic growth (PTGI), depressive symptoms (CES-D), and anxiety (SAS). Protective and vulnerability factors included resilience (CD-RISC), perceived social support (SSRS), physical activity (PARS-3), school belonging (PSSM), adaptive coping (SCSQ), and trait anxiety (TAI). Latent profile analysis (LPA) was used to identify adaptation profiles, and multinomial logistic regression examined how modifiable psychosocial factors were associated with profile membership. RESULTS: LPA revealed four empirically derived profiles: a High Distress/High Growth-Moderate PTSD profile (76.9%), a Low Distress-High Growth profile (4.8%), a Low Growth-Moderate Distress profile (3.9%), and a High Distress/High Growth-High PTSD profile (14.4%). The vast majority of adolescents showed some degree of both PTD and PTG, consistent with dual-process perspectives. In multinomial models, higher resilience, social support, school belonging, adaptive coping, and physical activity were associated with greater likelihood of belonging to the Low Distress-High Growth profile rather than more distressed profiles, whereas higher trait anxiety was associated with increased odds of membership in profiles characterized by greater distress. CONCLUSIONS: In this large school-based sample of Chinese adolescents, distress and growth frequently co-occurred and clustered into distinct adaptation profiles that differed systematically in psychosocial resources. Resilience, social connectedness, school belonging, and physical activity emerged as promising targets for trauma-informed, school-based support, whereas trait anxiety appeared to mark heightened vulnerability. Given the cross-sectional and single-region design, these findings should be interpreted as exploratory, and longitudinal and cross-cultural studies are needed to clarify temporal and contextual influences on adolescent trauma adaptation. CI - Copyright (c) 2026 Yang, Sun and Zhang. FAU - Yang, Haiying AU - Yang H AD - School of Physical Education, Southwest Jiaotong University, Chengdu, China. FAU - Sun, Lihong AU - Sun L AD - School of Physical Education, Hubei Second Normal University, Wuhan, China. FAU - Zhang, Ying AU - Zhang Y AD - School of Education, Hubei Second Normal University, Wuhan, China. LA - eng PT - Journal Article DEP - 20260128 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC12891221 OTO - NOTNLM OT - COVID-19 OT - adolescents OT - latent profile analysis OT - posttraumatic distress OT - posttraumatic growth COIS- The authors declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/13 06:32 MHDA- 2026/02/13 06:33 PMCR- 2026/01/28 CRDT- 2026/02/13 04:28 PHST- 2025/10/08 00:00 [received] PHST- 2026/01/03 00:00 [revised] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/02/13 06:33 [medline] PHST- 2026/02/13 06:32 [pubmed] PHST- 2026/02/13 04:28 [entrez] PHST- 2026/01/28 00:00 [pmc-release] AID - 10.3389/fpsyt.2026.1720487 [doi] PST - epublish SO - Front Psychiatry. 2026 Jan 28;17:1720487. doi: 10.3389/fpsyt.2026.1720487. eCollection 2026. PMID- 41684358 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Caregivers' perspectives on the in-home implementation and effectiveness of "Miffy eats the rainbow!": a colorful, modeling- and reward-based intervention to improve fruit and vegetable intake in children. PG - 1663525 LID - 10.3389/fpubh.2025.1663525 [doi] LID - 1663525 AB - BACKGROUND: Home-based interventions can support fruit and vegetable (FV) consumption in young children. Although their effectiveness is well documented, real-life implementation experiences remain understudied; such knowledge is crucial for sustained and scalable impact. Citizen science offers a promising approach for collecting large-scale, practice-based insights into how such interventions are used in daily life. OBJECTIVE: This study used a contributory citizen science approach to explore caregivers' experiences with the in-home implementation of "Miffy eats the rainbow!" and their perceptions of its effectiveness in supporting children's FV acceptance at home. METHODS: A total of 42,000 sticker sheets were distributed across 420 Dutch retail locations, supported by a national media campaign. Caregivers who used the method at least once were invited to complete an online questionnaire assessing implementation outcomes (acceptability, appropriateness, feasibility, sustainability) and perceived effects on children's FV enjoyment, variety, and amount. Quantitative data were analyzed using descriptive statistics and ANOVA (by food fussiness); qualitative responses were thematically analyzed using an inductive approach. RESULTS: A total of 209 caregivers participated (response rate: 0.5%). Implementation experiences were rated positively, with over 90% agreeing the method was fun (4.5 +/- 0.6), easy to use (4.4 +/- 0.7), and time efficient (4.3 +/- 0.7). Ratings remained consistently high across all food fussiness levels. Perceived effects on children's FV enjoyment, amount, and variety were slightly positive, with mean scores ranging from 3.2 +/- 1.0 to 3.6 +/- 1.0. Qualitative responses provided additional insights into benefits, implementation strategies, and barriers. CONCLUSIONS: "Miffy eats the rainbow!" was positively received by self-selected caregivers, with high implementation ratings suggesting potential for broader in-home application. However, the very low response rate highlights challenges in achieving voluntary participation and raises concerns about selection bias. Future efforts should aim to promote inclusive engagement and evaluate long-term use across more diverse populations. CI - Copyright (c) 2026 van der Heijden, Zeinstra, de Gooijer, Brouwer-Brolsma and Camps. FAU - van der Heijden, Zoe S AU - van der Heijden ZS AD - Division of Human Nutrition & Health, Wageningen University & Research, Wageningen, Netherlands. FAU - Zeinstra, Gertrude G AU - Zeinstra GG AD - Wageningen Food & Biobased Research, Food, Health & Consumer Research Group, Wageningen University & Research, Wageningen, Netherlands. FAU - de Gooijer, Femke J AU - de Gooijer FJ AD - Division of Human Nutrition & Health, Wageningen University & Research, Wageningen, Netherlands. FAU - Brouwer-Brolsma, Elske M AU - Brouwer-Brolsma EM AD - Division of Human Nutrition & Health, Wageningen University & Research, Wageningen, Netherlands. FAU - Camps, Guido AU - Camps G AD - Division of Human Nutrition & Health, Wageningen University & Research, Wageningen, Netherlands. AD - OnePlanet Research Center, Wageningen, Netherlands. LA - eng PT - Journal Article DEP - 20260112 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - *Fruit MH - *Vegetables MH - *Caregivers/psychology MH - Female MH - Male MH - *Health Promotion/methods MH - Netherlands MH - Child, Preschool MH - Surveys and Questionnaires MH - Child MH - Reward MH - *Feeding Behavior/psychology MH - Adult PMC - PMC12891986 OTO - NOTNLM OT - children OT - fruit OT - home-based OT - implementation OT - intervention OT - vegetables COIS- ZH reports that the materials used in the study were provided by Mercis bv. The remaining author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/13 06:33 MHDA- 2026/02/13 06:34 PMCR- 2026/01/12 CRDT- 2026/02/13 04:23 PHST- 2025/07/10 00:00 [received] PHST- 2025/11/24 00:00 [revised] PHST- 2025/12/16 00:00 [accepted] PHST- 2026/02/13 06:34 [medline] PHST- 2026/02/13 06:33 [pubmed] PHST- 2026/02/13 04:23 [entrez] PHST- 2026/01/12 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1663525 [doi] PST - epublish SO - Front Public Health. 2026 Jan 12;13:1663525. doi: 10.3389/fpubh.2025.1663525. eCollection 2025. PMID- 41683368 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 3 DP - 2026 Feb 6 TI - Dietary and Lifestyle Factors Associated with Self-Esteem in Adolescents: An Exploratory Questionnaire-Based Study. LID - 10.3390/nu18030546 [doi] LID - 546 AB - BACKGROUND: Self-esteem plays a central role in adolescent psychological health and may be shaped by everyday health behaviors such as eating patterns and engagement in physical activity. However, evidence from Eastern European youth remains comparatively limited. Lower levels of self-worth during adolescence have been linked to increased vulnerability to maladaptive behaviors, including substance use. The present study aimed to explore preliminary associations between lifestyle behaviors, nutritional practices, and self-esteem in a sample of Romanian adolescents. METHODS: A cross-sectional design was used, involving 113 participants aged 14-18 years. Self-esteem was assessed using the Rosenberg Self-Esteem Scale, while lifestyle behaviors were evaluated through a standardized questionnaire. Body mass index was calculated based on self-reported height and weight. Statistical analyses included Pearson correlation coefficients and multiple linear regression models. RESULTS: Higher self-esteem scores were strongly associated with greater participation in physical activity and adherence to a balanced diet, while inverse relationships were observed with unhealthy dietary habits and higher BMI values. Physical activity emerged as the most influential predictor of self-esteem, accounting for over three-quarters of the variance in Rosenberg scale scores. CONCLUSIONS: In this preliminary analysis, physical activity and healthier dietary behaviors were associated with higher self-esteem scores among adolescents. Given the exploratory nature of the study, these findings should be interpreted with caution. They primarily serve to generate hypotheses and highlight the need for future studies with validated instruments, larger samples, and appropriate control for potential confounding factors to better elucidate the relationship between lifestyle behaviors and adolescent self-esteem. FAU - Salcudean, Andreea AU - Salcudean A AD - Department of Bioethics, Deontology and Medical Communication, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania. FAU - Osz, Bianca-Eugenia AU - Osz BE AD - Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania. FAU - Cimpian, Dora-Mihaela AU - Cimpian DM AUID- ORCID: 0009-0005-0113-6748 AD - Department of Bioethics, Deontology and Medical Communication, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania. FAU - Popovici, Ramona-Amina AU - Popovici RA AUID- ORCID: 0000-0002-3852-9060 AD - Department of Management and Communication in Dental Medicine, Department I, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania. FAU - Bodo, Cristina-Raluca AU - Bodo CR AD - Department of Bioethics, Deontology and Medical Communication, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania. FAU - Torok, Sarolta AU - Torok S AD - Faculty of Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania. FAU - Corodan-Comiati, Diana-Mihaela AU - Corodan-Comiati DM AD - Psychiatry Clinic 1, County Clinical Hospital Mures, 540142 Targu Mures, Romania. FAU - Dumache, Raluca AU - Dumache R AUID- ORCID: 0000-0003-1790-8130 AD - Department of Forensic Medicine, Bioethics, Medical Ethics and Medical Law, Victor Babes University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania. FAU - Kis, Andreea-Mihaela AU - Kis AM AUID- ORCID: 0009-0004-4581-8487 AD - Department of Management and Communication in Dental Medicine, Department I, Faculty of Dental Medicine, Victor Babes University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania. FAU - Cincu, Madalina-Gabriela AU - Cincu MG AD - Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania. FAU - Grebenisan, Lorena-Mihaela AU - Grebenisan LM AUID- ORCID: 0000-0003-1745-9427 AD - Department of Psychiatry, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania. FAU - Strete, Elena-Gabriela AU - Strete EG AUID- ORCID: 0000-0003-2963-6793 AD - Department of Psychiatry, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540142 Targu Mures, Romania. LA - eng GR - 163/6/10.01.2023/George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures/ PT - Journal Article DEP - 20260206 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - *Self Concept MH - Female MH - Male MH - Cross-Sectional Studies MH - *Life Style MH - Surveys and Questionnaires MH - Body Mass Index MH - Exercise/psychology MH - *Adolescent Behavior/psychology MH - *Feeding Behavior/psychology MH - Romania MH - *Diet/psychology MH - Health Behavior PMC - PMC12899637 OTO - NOTNLM OT - BMI OT - adolescents OT - lifestyle OT - nutrition OT - physical activity OT - self-esteem COIS- The authors declare no conflicts of interest. EDAT- 2026/02/13 06:33 MHDA- 2026/02/13 06:34 PMCR- 2026/02/06 CRDT- 2026/02/13 01:08 PHST- 2026/01/12 00:00 [received] PHST- 2026/01/28 00:00 [revised] PHST- 2026/02/04 00:00 [accepted] PHST- 2026/02/13 06:34 [medline] PHST- 2026/02/13 06:33 [pubmed] PHST- 2026/02/13 01:08 [entrez] PHST- 2026/02/06 00:00 [pmc-release] AID - nu18030546 [pii] AID - nutrients-18-00546 [pii] AID - 10.3390/nu18030546 [doi] PST - epublish SO - Nutrients. 2026 Feb 6;18(3):546. doi: 10.3390/nu18030546. PMID- 41683338 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 3 DP - 2026 Feb 3 TI - The Impact of Physical Activity and Nutritional Patterns on Phase Angle in Healthy Adolescents. LID - 10.3390/nu18030516 [doi] LID - 516 AB - BACKGROUND: Phase angle (PhA), derived from bioelectrical impedance analysis (BIA), is a non-invasive parameter that reflects cellular integrity and nutritional status. Although PhA is increasingly used in pediatric settings, evidence on modifiable determinants in healthy adolescents remains limited. METHODS: This study was conducted in 56 adolescents (median age 16 years) who underwent BIA measurement including PhA at 50 kHz. Lifestyle and diet were assessed using the validated questionnaire and included physical activity level (school and free time), sleep length, and diet quality indices together with selected food intake frequencies. RESULTS: The median PhA was 5.16 degrees (IQR 4.88-5.46). In multivariable models, male sex (B = 0.96, p < 0.001) and higher free-time physical activity were independently associated with higher PhA, with graded effects for moderate (B = 0.42, p = 0.004) and high activity (B = 0.55, p = 0.001) versus low. Dietary indices and individual food items did not retain significance after adjustment. Penalized logistic models confirmed lower odds of low PhA with moderate (OR: 0.13, 95% CI: -3.66 to -0.56) and high (OR: 0.01, 95% CI: -9.15 to -1.87) versus low free-time activity. CONCLUSIONS: In healthy adolescents, habitual free-time physical activity is the main factor of PhA. These findings support the promotion of physical activity in youth as a modifiable determinant of cellular health. FAU - Przytula, Agata AU - Przytula A AUID- ORCID: 0009-0006-3818-8960 AD - Department of Clinical Dietetics, Medical University of Lublin, ul. Chodzki 7, 20-063 Lublin, Poland. FAU - Glibowski, Pawel AU - Glibowski P AUID- ORCID: 0000-0003-1774-6899 AD - Department of Biotechnology, Microbiology and Human Nutrition, University of Life Sciences in Lublin, 8 Skromna Str., 20-704 Lublin, Poland. FAU - Popiolek-Kalisz, Joanna AU - Popiolek-Kalisz J AUID- ORCID: 0000-0001-9108-8391 AD - Department of Clinical Dietetics, Medical University of Lublin, ul. Chodzki 7, 20-063 Lublin, Poland. LA - eng PT - Journal Article DEP - 20260203 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Adolescent MH - Female MH - *Exercise/physiology MH - *Nutritional Status MH - *Electric Impedance MH - Life Style MH - *Diet MH - *Body Composition MH - *Feeding Behavior MH - Surveys and Questionnaires PMC - PMC12899008 OTO - NOTNLM OT - bioelectrical impedance analysis OT - body composition OT - children OT - malnutrition OT - phase angle OT - physical activity COIS- The authors declare no conflicts of interest. EDAT- 2026/02/13 06:32 MHDA- 2026/02/13 06:33 PMCR- 2026/02/03 CRDT- 2026/02/13 01:08 PHST- 2026/01/15 00:00 [received] PHST- 2026/01/28 00:00 [revised] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/02/13 06:33 [medline] PHST- 2026/02/13 06:32 [pubmed] PHST- 2026/02/13 01:08 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - nu18030516 [pii] AID - nutrients-18-00516 [pii] AID - 10.3390/nu18030516 [doi] PST - epublish SO - Nutrients. 2026 Feb 3;18(3):516. doi: 10.3390/nu18030516. PMID- 41683334 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260729 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 3 DP - 2026 Feb 2 TI - Nutritional Status and Dietary Intakes of a Community of Rural Women in Barcena Villa Nueva, Guatemala: A Small-Scale Observational Study. LID - 10.3390/nu18030512 [doi] LID - 512 AB - Background/Objectives: Rural communities in Guatemala face a growing double-burden of malnutrition. Women of reproductive age are a key population to address, as their health and nutritional status influence not only their own well-being but also that of their children and families. However, they often experience greater exposure to nutritional risks due to gendered inequalities in access to resources, education, and health care. This small-scale observational study aimed to describe the dietary habits and nutritional status of a sub-group of women living in a rural area of Barcena Villa Nueva, Guatemala. Methods: An observational study was conducted between March and April 2025 among women aged >/=18 years from two rural communities. Dietary data were collected through structured interviews, 24 h dietary recall (24-hR), and a validated food frequency questionnaire (FFQ). Anthropometric and biochemical measurements were also collected. Results: A total of 22 women were included (mean age: 41.3 +/- 16.3 years). The prevalence of obesity and central obesity was 45.5% and 86.0%, respectively. Quantitative dietary assessment based on the 24 h recall showed a mean energy intake approximately 35% higher than the recommended values, with a high contribution from fats and carbohydrates and an excessive sodium intake. In contrast, intakes of potassium, zinc, and folic acid were below the recommended levels. The qualitative analysis of the food frequency questionnaire indicated a dietary pattern characterized by high consumption of carbohydrates, animal-based protein sources, traditional energy-dense foods, and ultra-processed products, alongside a limited intake of vegetables and fruits. Datary diversity was low (4.9, SD: 1.1). Conclusions: This small-scale observational scale study provides a preliminary overview of dietary patterns and nutritional status among women living in a rural community in Guatemala. Although the findings are not generalizable, they suggest the coexistence of excessive energy intake, suboptimal micronutrient intake, and low dietary diversity. These results underscore the need for further research using larger and more representative samples and may help inform the development of context-specific nutrition education initiatives in similar underserved settings. FAU - Basilico, Sara AU - Basilico S AUID- ORCID: 0000-0001-6860-6429 AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Sofroniou, Angeliki AU - Sofroniou A AUID- ORCID: 0000-0001-9862-5719 AD - Department of Food and Drug, University of Parma, 43121 Parma, Italy. FAU - Conti, Maria Vittoria AU - Conti MV AUID- ORCID: 0000-0002-8120-7091 AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Dieguez, Paola AU - Dieguez P AD - The Missionary Sisters of the Sacred Heart of Jesus, Cabrini Foundation, Zone 6, Guatemala City 01006, Guatemala. FAU - Cena, Hellas AU - Cena H AUID- ORCID: 0000-0002-5752-6199 AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. AD - Clinical Nutrition Unit, Istituti Clinici Scientifici Maugeri, Istituto di Ricovero e Cura a Carattere Scientifico, 27100 Pavia, Italy. AD - Italian Institute for Planetary Health, 00168 Rome, Italy. LA - eng GR - PE00000003/This research was funded under the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3 - Call for tender No. 341 of 15 March 2022 of Italian Ministry of University and Research funded by the European Union - NextGenerationEU/ PT - Journal Article PT - Observational Study DEP - 20260202 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Guatemala/epidemiology MH - Adult MH - *Nutritional Status MH - Middle Aged MH - *Rural Population/statistics & numerical data MH - *Diet/statistics & numerical data MH - Energy Intake MH - *Feeding Behavior MH - Young Adult MH - Nutrition Assessment MH - Adolescent MH - Obesity/epidemiology MH - Diet Surveys MH - Prevalence PMC - PMC12899360 OTO - NOTNLM OT - developing countries OT - dietary diversity OT - malnutrition double-burden OT - nutrition OT - obesity OT - women COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. The Cabrini Foundation had no role in the design of the study; in the collection, analysis, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/02/13 06:33 MHDA- 2026/02/13 06:34 PMCR- 2026/02/02 CRDT- 2026/02/13 01:08 PHST- 2025/11/19 00:00 [received] PHST- 2026/01/29 00:00 [revised] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/02/13 06:34 [medline] PHST- 2026/02/13 06:33 [pubmed] PHST- 2026/02/13 01:08 [entrez] PHST- 2026/02/02 00:00 [pmc-release] AID - nu18030512 [pii] AID - nutrients-18-00512 [pii] AID - 10.3390/nu18030512 [doi] PST - epublish SO - Nutrients. 2026 Feb 2;18(3):512. doi: 10.3390/nu18030512. PMID- 41683332 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 3 DP - 2026 Feb 2 TI - Dietary Diversity, Dietary Patterns, and Cardiometabolic Health in University Students: A Cross-Sectional Study. LID - 10.3390/nu18030511 [doi] LID - 511 AB - Background: Cardiometabolic risk is increasingly observed in young adults, particularly during university years, and is not limited to individuals with elevated body mass index. Emerging evidence highlights the presence of normal weight obesity-characterized by excess adiposity and unfavorable body composition despite normal BMI-which may confer early metabolic vulnerability. Dietary diversity is often promoted as a marker of dietary adequacy; however, its relationship with adiposity, body composition, and muscular health remains inconsistent, particularly in Latin American populations. Moreover, few studies have directly contrasted dietary diversity indicators with empirically derived dietary patterns in relation to cardiometabolic and functional outcomes. Objective: To examine the associations between dietary diversity, dietary patterns, and indicators of adiposity, muscular strength, and relative muscle mass in Ecuadorian university students. Methods: A cross-sectional study was conducted among 349 undergraduate students aged 18-26 years enrolled in health sciences programs in Ecuador. Dietary intake was assessed using a validated food frequency questionnaire. Dietary diversity was quantified using the Food and Agriculture Organization's Individual Dietary Diversity Score, while dietary patterns were identified through principal component analysis followed by k-means clustering. Outcomes included excess body weight, relative muscle mass assessed by bioelectrical impedance analysis, and handgrip strength. Multivariable Poisson and linear regression models were fitted, adjusting for age, sex, academic program, physical activity level, and pre-existing conditions. Results: Despite their young age and low prevalence of diagnosed disease, approximately one-third of the participants exhibited markers of early cardiometabolic risk, including excess body weight and central adiposity. Higher dietary diversity was independently associated with a higher prevalence of excess body weight (adjusted prevalence ratio per one-unit increase in IDDS: 1.17; 95% CI: 1.06-1.30) and with greater relative muscle mass (adjusted beta = 0.13; 95% CI: 0.05-0.22), whereas no association was observed with handgrip strength. In contrast, dietary patterns derived from multivariate analysis showed no significant associations with adiposity, muscular strength, or relative muscle mass after adjustment. Conclusions: In this young adult population, dietary diversity captured aspects of overall dietary exposure associated with both increased adiposity and greater lean mass, but not with muscular strength. Empirically derived dietary patterns demonstrated limited discriminatory capacity, likely reflecting dietary homogeneity within the cohort. These findings indicate that dietary diversity alone does not necessarily reflect diet quality and underscore the importance of interpreting diversity metrics alongside indicators of food quality, energy density, and body composition when evaluating early cardiometabolic risk in contemporary food environments. FAU - Fonseca-Perez, Diana AU - Fonseca-Perez D AUID- ORCID: 0000-0002-6437-2730 AD - Carrera de Nutricion y Dietetica, Facultad de Ciencias de la Salud, Universidad Catolica de Santiago de Guayaquil, Guayaquil 090615, Ecuador. FAU - Alvarez-Cordova, Ludwig AU - Alvarez-Cordova L AUID- ORCID: 0000-0002-6116-6122 AD - Maestria de Nutricion y Dietetica, Facultad de Ciencias de la Salud, Universidad de Las Americas (UDLA), Quito 170503, Ecuador. FAU - Arteaga-Pazmino, Cecilia AU - Arteaga-Pazmino C AUID- ORCID: 0000-0003-2472-3820 AD - Carrera de Nutricion y Dietetica, Facultad de Ciencias Medicas, Universidad de Guayaquil, Guayaquil 090615, Ecuador. FAU - Sierra-Nieto, Victor AU - Sierra-Nieto V AUID- ORCID: 0000-0002-0052-9209 AD - Carrera de Fisioterapia, Facultad de Ciencias de la Salud, Universidad Catolica de Santiago de Guayaquil, Guayaquil 090615, Ecuador. FAU - Cagua-Ordonez, Jaen AU - Cagua-Ordonez J AUID- ORCID: 0000-0002-1684-5206 AD - Facultad de Ciencias de la Salud y Bienestar Humano, Universidad Tecnologica Indoamerica, Quito 170103, Ecuador. FAU - Frias-Toral, Evelyn AU - Frias-Toral E AUID- ORCID: 0000-0002-2228-0141 AD - Escuela de Medicina, Universidad Espiritu Santo, Samborondon 0901952, Ecuador. AD - Division of Research, Texas State University, 601 University Dr., San Marcos, TX 78666, USA. FAU - Muscogiuri, Giovanna AU - Muscogiuri G AUID- ORCID: 0000-0002-8809-4931 AD - Endocrinology Unit, Department of Clinical Medicine and Surgery, Federico II University, 80131 Naples, Italy. AD - Italian Centre for the Care and Wellbeing of Patients with Obesity, Federico II University Hospital, 80131 Naples, Italy. AD - UNESCO Chair on Health Education and Sustainable Development, Federico II University, 80131 Naples, Italy. FAU - Reytor-Gonzalez, Claudia AU - Reytor-Gonzalez C AUID- ORCID: 0009-0007-4234-5524 AD - Facultad de Ciencias de la Salud y Bienestar Humano, Universidad Tecnologica Indoamerica, Ambato 180150, Ecuador. FAU - Simancas-Racines, Daniel AU - Simancas-Racines D AUID- ORCID: 0000-0002-3641-1501 AD - Facultad de Ciencias de la Salud y Bienestar Humano, Universidad Tecnologica Indoamerica, Ambato 180150, Ecuador. LA - eng PT - Journal Article DEP - 20260202 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - Young Adult MH - Adult MH - Universities MH - Adolescent MH - *Students/statistics & numerical data MH - *Diet MH - Adiposity MH - Body Composition MH - Ecuador/epidemiology MH - Body Mass Index MH - *Feeding Behavior MH - Hand Strength PMC - PMC12899775 OTO - NOTNLM OT - Latin America OT - body composition OT - cardiometabolic risk OT - dietary diversity OT - dietary patterns OT - muscle mass OT - university students OT - young adults COIS- The authors declare that they have no commercial or financial relationships that could be construed as potential conflicts of interest. EDAT- 2026/02/13 06:33 MHDA- 2026/02/13 06:34 PMCR- 2026/02/02 CRDT- 2026/02/13 01:08 PHST- 2025/12/26 00:00 [received] PHST- 2026/01/28 00:00 [revised] PHST- 2026/01/29 00:00 [accepted] PHST- 2026/02/13 06:34 [medline] PHST- 2026/02/13 06:33 [pubmed] PHST- 2026/02/13 01:08 [entrez] PHST- 2026/02/02 00:00 [pmc-release] AID - nu18030511 [pii] AID - nutrients-18-00511 [pii] AID - 10.3390/nu18030511 [doi] PST - epublish SO - Nutrients. 2026 Feb 2;18(3):511. doi: 10.3390/nu18030511. PMID- 41683282 OWN - NLM STAT- MEDLINE DCOM- 20260721 LR - 20260721 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 3 DP - 2026 Jan 30 TI - Predictors and Risk Scoring of Postnatal Growth Failure in Very-Low-Birth-Weight Infants. LID - 10.3390/nu18030460 [doi] LID - 460 AB - Objectives: To identify factors associated with postnatal growth failure (PGF) in very-low-birth-weight (VLBW) infants and to develop a model for the early identification of neonates at risk. Methods: This retrospective cohort study included VLBW infants born between 2014 and 2024. PGF was defined using the 2013 Fenton growth chart. Multivariate logistic regression was used to identify predictors of PGF, and a weighted risk score was derived from their relative contributions. Model performance was evaluated using a receiver operating characteristic (ROC) curve. Results: Among 481 VLBW infants, 334 (69.4%) had PGF. Independent predictors were birth weight < 750 g (adjusted odds ratio [aOR] 8.11; 95% confidence interval [CI], 3.01-21.83), birth weight 750-1000 g (aOR 2.39; 95% CI, 1.35-4.21), multiple births (aOR 2.82; 95% CI, 1.71-4.67), pregnancy-induced hypertension (PIH) (aOR 3.32; 95% CI, 2.02-5.46), oligohydramnios (aOR 4.08; 95% CI, 1.68-9.92), no antenatal corticosteroid exposure (aOR 2.97; 95% CI, 1.65-5.36), and formula or mixed feeding (aOR 1.69; 95% CI, 1.08-2.64). The model showed good discrimination for scores >/=2 (area under the ROC curve, 0.736; sensitivity, 71.6%; specificity, 64.5%). Conclusions: Birth weight < 1000 g, multiple births, PIH, oligohydramnios, no antenatal corticosteroid exposure, and formula or mixed feeding were significant predictors of PGF. The score may support early risk stratification and prompt closer nutritional surveillance. FAU - Singhasem, Nutcha AU - Singhasem N AD - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand. FAU - Maneenil, Gunlawadee AU - Maneenil G AUID- ORCID: 0000-0002-6332-3216 AD - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand. FAU - Thatrimontrichai, Anucha AU - Thatrimontrichai A AUID- ORCID: 0000-0003-2363-6362 AD - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand. FAU - Praditaukrit, Manapat AU - Praditaukrit M AUID- ORCID: 0000-0002-9176-7383 AD - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand. FAU - Dissaneevate, Supaporn AU - Dissaneevate S AD - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Songkhla 90110, Thailand. LA - eng PT - Journal Article DEP - 20260130 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - *Infant, Very Low Birth Weight/growth & development MH - Retrospective Studies MH - Humans MH - Male MH - Female MH - Infant, Newborn MH - *Growth Disorders/diagnosis/etiology MH - *Risk Assessment/methods/standards MH - *Predictive Learning Models MH - Predictive Value of Tests MH - Reproducibility of Results MH - ROC Curve MH - *Infant, Premature/growth & development MH - Risk Factors PMC - PMC12899935 OTO - NOTNLM OT - extrauterine growth retardation OT - postnatal growth failure OT - predictions OT - preterm infant OT - risk factors COIS- The authors declare no conflicts of interest manuscript. EDAT- 2026/02/13 06:32 MHDA- 2026/02/13 06:33 PMCR- 2026/01/30 CRDT- 2026/02/13 01:08 PHST- 2026/01/06 00:00 [received] PHST- 2026/01/24 00:00 [revised] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/02/13 06:33 [medline] PHST- 2026/02/13 06:32 [pubmed] PHST- 2026/02/13 01:08 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - nu18030460 [pii] AID - nutrients-18-00460 [pii] AID - 10.3390/nu18030460 [doi] PST - epublish SO - Nutrients. 2026 Jan 30;18(3):460. doi: 10.3390/nu18030460. PMID- 41683279 OWN - NLM STAT- MEDLINE DCOM- 20260721 LR - 20260721 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 3 DP - 2026 Jan 30 TI - Analysis of the Inter-Scale Agreement of Questionnaires to Assess the Emotional Eating in a Population of Polish Girls: PLACE-19 Study. LID - 10.3390/nu18030457 [doi] LID - 457 AB - Background/Objectives: Emotional eating is a tendency to increase food consumption in order to modify a negative emotional state, but little is known about this phenomenon or about the way to assess it. The aim of the study was to assess the emotional eating in the population of Polish girls using various questionnaires, in order to compare the results obtained while using various tools. Methods: The emotional eating was assessed in a sample of n = 771 girls (age 15-18 years) from a nationwide PLACE-19 Study population, recruited based on a random quota sampling of Polish secondary schools. The results were gathered within the Computer-Assisted Web Interview (CAWI) and compared for four tools: Emotional Eating Scale for Children and adolescents (EES-C), Emotional Eating Subscale (EE-3) of Three-Factor Eating Questionnaire (TFEQ), Emotional Overeating Questionnaire (EOQ-5), and Emotional Eater Questionnaire (EEQ). Results: The analysis of correlation revealed statistically significant association for comparison of all the questionnaires (p < 0.001). For a comparison of EE-3 and EOQ-5, the strongest correlation between the results, and the second highest share of the studied group presenting agreement in emotional eating category was stated, indicating the strongest agreement. For a comparison of EES-C and EOQ-5, as well as EES-C and EEQ, the weakest correlation between the results, and the lowest share of the studied group presenting agreement in emotional eating category was stated, indicating the weakest agreement. Conclusions: It may be suggested that in studies conducted in a group of girls the recommended approach would be to use at least two various questionnaires to assess emotional eating, to enable comparing results, as the knowledge gathered so far does not allow an indication of the most reliable tool. As there is only a fair agreement between compared tools, the arbitrary choice of one tool may significantly influence the formulated conclusions. Moreover, there is a need to conduct more studies assessing emotional eating while using various questionnaire methods, in order to compare the results obtained while using various tools and to indicate the most reliable questionnaires. FAU - Guzek, Dominika AU - Guzek D AUID- ORCID: 0000-0002-0784-3604 AD - Department of Food Market and Consumer Research, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW-WULS), 159C Nowoursynowska Street, 02-776 Warsaw, Poland. FAU - Skolmowska, Dominika AU - Skolmowska D AUID- ORCID: 0000-0002-5818-9884 AD - Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW-WULS), 159C Nowoursynowska Street, 02-776 Warsaw, Poland. FAU - Glabska, Dominika AU - Glabska D AUID- ORCID: 0000-0001-8588-7357 AD - Department of Dietetics, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (SGGW-WULS), 159C Nowoursynowska Street, 02-776 Warsaw, Poland. LA - eng GR - 0/This research was funded by the Polish Ministry of Education and Science within funds of In-stitute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS), for scientific research./ PT - Comparative Study PT - Journal Article DEP - 20260130 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adolescent MH - Poland/epidemiology MH - *Emotional Eating/psychology MH - *Surveys and Questionnaires/standards MH - *Behavior Rating Scale/standards MH - Reproducibility of Results MH - *Feeding and Eating Disorders/diagnosis/psychology PMC - PMC12899171 OTO - NOTNLM OT - PLACE-19 Study OT - adolescent OT - emotional eating OT - self-report OT - surveys and questionnaires OT - women COIS- The authors declare no conflict of interest. EDAT- 2026/02/13 06:33 MHDA- 2026/02/13 06:34 PMCR- 2026/01/30 CRDT- 2026/02/13 01:08 PHST- 2025/12/16 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/02/13 06:34 [medline] PHST- 2026/02/13 06:33 [pubmed] PHST- 2026/02/13 01:08 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - nu18030457 [pii] AID - nutrients-18-00457 [pii] AID - 10.3390/nu18030457 [doi] PST - epublish SO - Nutrients. 2026 Jan 30;18(3):457. doi: 10.3390/nu18030457. PMID- 41683266 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 3 DP - 2026 Jan 29 TI - Acceptability and Adherence to Ready-to-Use Therapeutic Foods (RUTFs) Treatment in Cases of Moderate and Severe Acute Malnutrition in Children from Rural and Indigenous Communities in Mexico. LID - 10.3390/nu18030444 [doi] LID - 444 AB - Background/Objectives: Infant acute malnutrition increases the risk of morbidity and mortality but also has adverse effects on growth, cognitive development, and quality of life. Ready-to-use therapeutic foods (RUTFs) represent the standard treatment in moderate (MAM) or severe acute malnutrition (SAM) cases, but acceptability and adherence in culturally diverse settings remain poorly understood. To evaluate the acceptability and adherence to RUTF treatment among children with MAM or SAM in rural and indigenous communities of three Mexican states. Methods: We conducted a mixed-methods study in Chihuahua, Guerrero, and Chiapas between February and August 2024. A total of 66 children aged 6-59 months with confirmed MAM or SAM diagnoses were enrolled, with 48 completing the study. Acceptability was assessed by weighing leftovers of the consumption RUTF sachet and using 5-point hedonic scales evaluating taste, texture, appearance, and smell. Adherence was measured by comparing consumed versus prescribed RUTF sachets. Semi-structured interviews with primary caregivers explored perceptions, barriers, and facilitators of RUTF use. Results: Consumption-based acceptability was achieved by 85% of participants. On the 5-point hedonic scale, 77% of participants rated RUTF as pleasant or very pleasant. Overall treatment adherence was adequate (>/=70%) in 79.2% of cases. Qualitative information revealed primary caregivers' perceptions about weight gain and increased appetite as benefits. Conclusions: Since acceptability and adherence were adequate and a high score was obtained on the hedonic scale, which led to an improvement in the nutritional status of MAM or SAM cases, the feasibility and acceptability of RUTFs in highly vulnerable community contexts in Mexico was reaffirmed. FAU - Chavez Munoz, Edgar Arturo AU - Chavez Munoz EA AUID- ORCID: 0009-0005-5043-6202 AD - Nutrition and Health Research Center (CINyS), National Institute of Public Health of Mexico (NIPH), Avenida Universidad 655, Santa Maria Ahuacatitlan, Cuernavaca 62100, Mexico. FAU - Lozada Tequeanes, Ana Lilia AU - Lozada Tequeanes AL AUID- ORCID: 0000-0002-7371-3525 AD - Nutrition and Health Research Center (CINyS), National Institute of Public Health of Mexico (NIPH), Avenida Universidad 655, Santa Maria Ahuacatitlan, Cuernavaca 62100, Mexico. FAU - Pacheco Miranda, Selene AU - Pacheco Miranda S AD - Nutrition and Health Research Center (CINyS), National Institute of Public Health of Mexico (NIPH), Avenida Universidad 655, Santa Maria Ahuacatitlan, Cuernavaca 62100, Mexico. FAU - Dorantes Pacheco, Leonel AU - Dorantes Pacheco L AUID- ORCID: 0000-0001-7341-8553 AD - Nutrition and Health Research Center (CINyS), National Institute of Public Health of Mexico (NIPH), Avenida Universidad 655, Santa Maria Ahuacatitlan, Cuernavaca 62100, Mexico. FAU - Castaneda Barrios, Mariana AU - Castaneda Barrios M AD - Nutrition and Health Research Center (CINyS), National Institute of Public Health of Mexico (NIPH), Avenida Universidad 655, Santa Maria Ahuacatitlan, Cuernavaca 62100, Mexico. FAU - Cueva-Chamba, Alexander AU - Cueva-Chamba A AUID- ORCID: 0000-0001-5735-0691 AD - Nutrition and Health Research Center (CINyS), National Institute of Public Health of Mexico (NIPH), Avenida Universidad 655, Santa Maria Ahuacatitlan, Cuernavaca 62100, Mexico. FAU - Bonvecchio Arenas, Anabelle AU - Bonvecchio Arenas A AUID- ORCID: 0000-0002-2765-0818 AD - Nutrition and Health Research Center (CINyS), National Institute of Public Health of Mexico (NIPH), Avenida Universidad 655, Santa Maria Ahuacatitlan, Cuernavaca 62100, Mexico. FAU - Sachse, Matthias AU - Sachse M AD - United Nations International Children's Emergency Fund (UNICEF) of Mexico, Avenida Paseo de la Reforma 645, Lomas de Chapultepec, Miguel Hidalgo, Ciudad de Mexico 11000, Mexico. FAU - de Bustos, Cecilia AU - de Bustos C AD - United Nations International Children's Emergency Fund (UNICEF) of Mexico, Avenida Paseo de la Reforma 645, Lomas de Chapultepec, Miguel Hidalgo, Ciudad de Mexico 11000, Mexico. LA - eng GR - None/UNICEF-Mexico/ PT - Journal Article DEP - 20260129 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Mexico MH - Male MH - Female MH - Infant MH - Child, Preschool MH - Rural Population MH - *Severe Acute Malnutrition/diet therapy MH - *Patient Acceptance of Health Care MH - Food, Processed MH - *Patient Compliance MH - *Infant Nutrition Disorders/diet therapy PMC - PMC12899508 OTO - NOTNLM OT - Mexico OT - RUTF OT - acceptability OT - adherence OT - children OT - moderate and severe acute malnutrition COIS- The authors declare no conflicts of interest. The funders and RUTF manufacturers had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/02/13 06:32 MHDA- 2026/02/13 06:33 PMCR- 2026/01/29 CRDT- 2026/02/13 01:08 PHST- 2025/12/15 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/01/26 00:00 [accepted] PHST- 2026/02/13 06:33 [medline] PHST- 2026/02/13 06:32 [pubmed] PHST- 2026/02/13 01:08 [entrez] PHST- 2026/01/29 00:00 [pmc-release] AID - nu18030444 [pii] AID - nutrients-18-00444 [pii] AID - 10.3390/nu18030444 [doi] PST - epublish SO - Nutrients. 2026 Jan 29;18(3):444. doi: 10.3390/nu18030444. PMID- 41683262 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 3 DP - 2026 Jan 29 TI - Prediction Models for Early Identification of Overweight and Obese Children-A National Study. LID - 10.3390/nu18030441 [doi] LID - 441 AB - BACKGROUND: Given the importance of early-life intervention in reducing future obesity, screening models that more accurately identify infants at risk are crucial. The aim of this study was to develop models based solely on growth parameters for better predicting childhood overweight than the current WHO growth chart risk prediction. METHODS: A retrospective national cohort study was conducted among children born in Israel between August 2014 and June 2016, followed for at least 18 months. Machine learning models were generated to predict childhood overweight. Three models for 0-3, 3-6, and 6-12 months were generated. These models were compared with the current WHO growth chart predictions. The outcome was defined as overweight in early childhood, based on weight-for-length (or weight-for-height) >/=97th percentile, according to WHO standards, measured at 18-36 months of age. RESULTS: Overall, 198,503 children were included, and 150,572, 146,584, and 149,628 infants were included in Models 1, 2, and 3, respectively, with an average target age of two years. The models demonstrated high predictive performance (AUC) for the 0-3 months' model (0.76 [95% CI: 75 to 76.9%]), for the 3-6 months' model (0.822 [95% CI: 81.3 to 83.0%]) and for 6-12-month-old infants (0.872 [95% CI: 86.6 to 87.8%]). The first two models better predict the risk of early childhood overweight than the current WHO growth chart prediction. CONCLUSIONS: These models are unique in that they are based on growth parameters, usually screened at early childhood worldwide, and can be implemented in any system collecting growth measurements of infants, providing better risk prediction than the current WHO growth charts. A web calculator is provided. FAU - Sadaka, Irit Lior AU - Sadaka IL AD - Department of Health Policy and Management, School of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er-Sheva 84105, Israel. FAU - Grotto, Itamar AU - Grotto I AUID- ORCID: 0000-0002-3363-3715 AD - Department of Epidemiology, Biostatistics, and Community Health Sciences, Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er-Sheva 84105, Israel. FAU - Sadaka, Yair AU - Sadaka Y AD - INSPIRE Institute, Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er-Sheva 84105, Israel. FAU - Eilenberg, Roni AU - Eilenberg R AD - Timna Initiative, Ministry of Health, Jerusalem 9446724, Israel. FAU - Peleg, Assaf AU - Peleg A AD - INSPIRE Institute, Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er-Sheva 84105, Israel. FAU - Greenberg, Dan AU - Greenberg D AD - Department of Health Policy and Management, School of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Be'er-Sheva 84105, Israel. LA - eng PT - Journal Article DEP - 20260129 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Infant MH - Retrospective Studies MH - Male MH - Female MH - Child, Preschool MH - *Pediatric Obesity/diagnosis/epidemiology MH - Israel/epidemiology MH - Predictive Learning Models MH - Infant, Newborn MH - Growth Charts MH - Machine Learning MH - *Overweight/diagnosis MH - Prediction Algorithms MH - Risk Assessment MH - Risk Factors MH - Predictive Value of Tests PMC - PMC12899778 OTO - NOTNLM OT - WHO growth standards OT - anthropometric data OT - childhood obesity OT - early risk prediction OT - growth monitoring OT - infant growth OT - obesity prevention COIS- The authors declare no conflicts of interest. EDAT- 2026/02/13 06:33 MHDA- 2026/02/13 06:34 PMCR- 2026/01/29 CRDT- 2026/02/13 01:08 PHST- 2026/01/10 00:00 [received] PHST- 2026/01/24 00:00 [revised] PHST- 2026/01/26 00:00 [accepted] PHST- 2026/02/13 06:34 [medline] PHST- 2026/02/13 06:33 [pubmed] PHST- 2026/02/13 01:08 [entrez] PHST- 2026/01/29 00:00 [pmc-release] AID - nu18030441 [pii] AID - nutrients-18-00441 [pii] AID - 10.3390/nu18030441 [doi] PST - epublish SO - Nutrients. 2026 Jan 29;18(3):441. doi: 10.3390/nu18030441. PMID- 41682738 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260213 LR - 20260216 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 3 DP - 2026 Jan 28 TI - Anthropometric and Body Composition Correlates of Hypertension in Children and Adolescents with Intellectual Disabilities. LID - 10.3390/jcm15031058 [doi] LID - 1058 AB - Background/Objectives: Children and adolescents with intellectual disabilities (ID) have an elevated burden of obesity and cardiometabolic risk, yet factors associated with high blood pressure (BP) in this group remain insufficiently described. This study assessed the prevalence of hypertension (HTN) and isolated systolic hypertension (ISH) at a single visit and examined anthropometric and body composition correlates of elevated BP in children with ID. Methods: A cross-sectional study was conducted among 461 children and adolescents with ID aged 7-18 y attending special education schools in southeastern Poland. Anthropometric indicators (BMI, waist circumference [WC], hip circumference [HC], and waist-to-height ratio [WHtR]) and body composition parameters (BF%, MM%, FFM%, TBW%) were measured using standardized procedures. BP was assessed three times during one visit, and the average of the second and third readings was used. Receiver operating characteristic (ROC) analyses were used for exploratory assessment of discriminatory performance of anthropometric and body composition parameters, and multivariable logistic regression examined associations with elevated BP (HTN + ISH). Results: Overall, 13.9% of participants had HTN and 10.4% had ISH (combined prevalence: 24.3%). Abdominal obesity was present in 39.5% of participants, and elevated HC in 28.2%, both more common in girls. Higher BP categories were associated with greater WC, HC, BMI, and BF%, and lower MM%, FFM%, and TBW% (p < 0.0001). HC showed the highest discriminatory accuracy for HTN + ISH (AUC = 0.844), followed by MM%, BF%, and FFM%, whereas WHtR demonstrated limited discriminatory performance in ROC analyses. In multivariable models, WHtR >/= 0.5 was associated with increased odds of elevated BP (OR = 4.25), whereas higher TBW% (>/=55.38%) was inversely associated with elevated BP (OR = 0.17) in the total sample; similar patterns were observed in sex- and age-stratified analyses. Conclusions: Children with ID show a high prevalence of elevated BP at a single visit, including HTN-range and ISH-range values. Anthropometric indicators, particularly HC and WHtR, and BIA-derived body composition parameters reflecting higher fat mass and lower lean tissue proportion were associated with elevated BP. These exploratory findings suggest that simple anthropometric and body composition measures may help identify individuals who warrant further BP assessment, although longitudinal studies with repeated measurements are required before clinical application. FAU - Wyszynska, Justyna AU - Wyszynska J AUID- ORCID: 0000-0002-5786-6214 AD - Faculty of Medical Sciences and Psychology, Medical College of Rzeszow University, 35-959 Rzeszow, Poland. FAU - Deren, Katarzyna AU - Deren K AUID- ORCID: 0000-0002-0977-5844 AD - Faculty of Medical Sciences and Psychology, Medical College of Rzeszow University, 35-959 Rzeszow, Poland. FAU - Mazur, Artur AU - Mazur A AD - Medical Faculty, Medical College of Rzeszow University, 35-959 Rzeszow, Poland. FAU - Matlosz, Piotr AU - Matlosz P AUID- ORCID: 0000-0002-7388-5722 AD - Faculty of Physical Culture Sciences, Medical College of Rzeszow University, 35-959 Rzeszow, Poland. LA - eng PT - Journal Article DEP - 20260128 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC12897980 OTO - NOTNLM OT - adolescents OT - anthropometry OT - body composition OT - children OT - hypertension OT - intellectual disability OT - isolated systolic hypertension OT - obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/02/13 06:32 MHDA- 2026/02/13 06:33 PMCR- 2026/01/28 CRDT- 2026/02/13 01:06 PHST- 2025/12/03 00:00 [received] PHST- 2026/01/08 00:00 [revised] PHST- 2026/01/23 00:00 [accepted] PHST- 2026/02/13 06:33 [medline] PHST- 2026/02/13 06:32 [pubmed] PHST- 2026/02/13 01:06 [entrez] PHST- 2026/01/28 00:00 [pmc-release] AID - jcm15031058 [pii] AID - jcm-15-01058 [pii] AID - 10.3390/jcm15031058 [doi] PST - epublish SO - J Clin Med. 2026 Jan 28;15(3):1058. doi: 10.3390/jcm15031058. PMID- 41682678 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260213 LR - 20260216 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 3 DP - 2026 Jan 26 TI - Development and Validation of a Tool to Assess Disease-Related Knowledge in Children with Coeliac Disease. LID - 10.3390/jcm15030997 [doi] LID - 997 AB - Background/Objectives: Assessment of disease-specific knowledge levels among children with coeliac disease (CD) is essential to support self-management of their condition. A suitable knowledge assessment tool has not yet been identified that is appropriate for children. The aim of this study was to develop and validate a tool for this purpose. Materials and Methods: Using content synthesis of available literature, a CD knowledge assessment tool (CD-Know) was developed to include items shown to be relevant to the management of CD for children. CD-Know went through development stages of expert review, two rounds of pilot/validation testing, and item response analysis. CD-Know scores were compared between participant groups using a univariate linear model. Results: CD-Know was developed using content synthesis and review by international CD experts. CD-Know was initially piloted among adults/children with CD (n = 12) and underwent the first validation study (n = 330 participants) among adults/children with CD, cohabitants, healthcare professionals (HCPs), and groups without CD. Based on item response analysis the tool was modified. The phases of the pilot (n = 7) and validation studies were repeated among refined groups (n = 230). The final 15-item CD-Know demonstrated an appropriate hierarchy of knowledge between testing groups. Children with CD scored lower than cohabitants of someone with CD (mean difference (MD) -3.0, SD 0.4, p < 0.001) and HCPs (MD -1.7, p = 0.009), at a similar level to adults without CD (MD 0.6, p = 0.88), and higher than children without CD (MD 5.8, p < 0.001). The CD-Know score of children with CD was positively associated with their adherence level to a gluten-free diet (R 0.30, p = 0.017). Test-retest reliability had a good intraclass correlation coefficient (R 0.73, p = 0.003). Internal consistency was good (Cronbach's alpha 0.71). Conclusions: CD-Know is a validated tool to assess disease-related knowledge in children diagnosed with CD. Its potential applications include identifying areas for knowledge enhancement within the population and assessment of CD interventions. FAU - Hall, Sophie AU - Hall S AUID- ORCID: 0009-0007-3530-0264 AD - Department of Paediatrics and Child Health, University of Otago Christchurch, 4 Oxford Terrace, Christchurch 8011, New Zealand. AD - Department of Paediatrics, Christchurch Hospital, 2 Riccarton Avenue, Christchurch 8011, New Zealand. FAU - Kenrick, Kristin AU - Kenrick K AUID- ORCID: 0000-0002-4608-4292 AD - Department of General Practice and Rural Health, Dunedin School of Medicine, Rm 124, 55 Hannover Street, Dunedin 9016, New Zealand. FAU - Coppell, Kirsten J AU - Coppell KJ AUID- ORCID: 0000-0003-0996-2874 AD - Department of Medicine, University of Otago Wellington, P.O. Box 7343, Wellington 6242, New Zealand. FAU - Day, Andrew S AU - Day AS AUID- ORCID: 0000-0003-2290-7386 AD - Department of Paediatrics and Child Health, University of Otago Christchurch, 4 Oxford Terrace, Christchurch 8011, New Zealand. FAU - Vernon-Roberts, Angharad AU - Vernon-Roberts A AUID- ORCID: 0000-0001-9402-4959 AD - Department of Paediatrics and Child Health, University of Otago Christchurch, 4 Oxford Terrace, Christchurch 8011, New Zealand. LA - eng PT - Journal Article DEP - 20260126 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC12898186 OTO - NOTNLM OT - children OT - coeliac disease OT - content validity OT - knowledge OT - readability OT - validation COIS- The authors declare no conflict of interest. EDAT- 2026/02/13 06:32 MHDA- 2026/02/13 06:33 PMCR- 2026/01/26 CRDT- 2026/02/13 01:06 PHST- 2025/12/11 00:00 [received] PHST- 2026/01/21 00:00 [revised] PHST- 2026/01/22 00:00 [accepted] PHST- 2026/02/13 06:33 [medline] PHST- 2026/02/13 06:32 [pubmed] PHST- 2026/02/13 01:06 [entrez] PHST- 2026/01/26 00:00 [pmc-release] AID - jcm15030997 [pii] AID - jcm-15-00997 [pii] AID - 10.3390/jcm15030997 [doi] PST - epublish SO - J Clin Med. 2026 Jan 26;15(3):997. doi: 10.3390/jcm15030997. PMID- 41682210 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260213 LR - 20260216 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 3 DP - 2026 Jan 30 TI - Associations Between 24 h Movement Behaviours and Cognitive Abilities in Slovak Adolescents: A Cross-Sectional Study. LID - 10.3390/healthcare14030360 [doi] LID - 360 AB - BACKGROUND: Twenty-four-hour movement behaviours (physical activity, sedentary time, and sleep) may be associated with adolescent cognitive performance, but evidence from Central/Eastern Europe is limited. METHODS: A total of 82 Slovak adolescents (15-19 years) completed tests of IQ, attention, and visual memory. Participants wore a wrist accelerometer 24/7 for seven consecutive days (processed in GGIR v3.0-3). Moderate-to-vigorous physical activity (MVPA), total sedentary time, and sleep duration were derived from accelerometry; physical activity was also self-reported using the Physical Activity Questionnaire for Adolescents (PAQ-A). Non-parametric tests and Spearman correlations were applied; sleep x MVPA interaction models (robust HC3 standard errors) were adjusted for age and sex. RESULTS: MVPA was low (median 32.9 min/day; 11% met >/=60 min/day), while sedentary time was high (median 652.6 min/day). Associations between movement behaviours and cognition were generally small, and no sleep x MVPA interaction effects were observed. The PAQ-A overestimated device-based MVPA (mean bias +1.68 units; 95% limits of agreement +1.10 to +2.25), with greater overestimation in girls and older adolescents. CONCLUSIONS: In this convenience sample, 24 h movement patterns were suboptimal, and their associations with cognition were modest and exploratory. Larger longitudinal studies are needed to confirm these findings. FAU - Ruzbarska, Beata AU - Ruzbarska B AUID- ORCID: 0000-0002-9000-0527 AD - Faculty of Sport, University of Presov, 17. Novembra 15, 080 01 Presov, Slovakia. FAU - Hnidkova, Lenka AU - Hnidkova L AUID- ORCID: 0000-0002-6028-2738 AD - Faculty of Sport, University of Presov, 17. Novembra 15, 080 01 Presov, Slovakia. FAU - Trebunak, Mojmir AU - Trebunak M AD - Faculty of Sport, University of Presov, 17. Novembra 15, 080 01 Presov, Slovakia. FAU - Chovanova, Erika AU - Chovanova E AUID- ORCID: 0000-0002-3197-3425 AD - Faculty of Sport, University of Presov, 17. Novembra 15, 080 01 Presov, Slovakia. FAU - Dzugas, Dalibor AU - Dzugas D AUID- ORCID: 0000-0002-4281-0437 AD - Faculty of Sport, University of Presov, 17. Novembra 15, 080 01 Presov, Slovakia. FAU - Kacur, Peter AU - Kacur P AUID- ORCID: 0000-0001-7682-0871 AD - Faculty of Sport, University of Presov, 17. Novembra 15, 080 01 Presov, Slovakia. LA - eng GR - 1/0481/22/Slovak Republic and the Slovak Academy of Sciences (VEGA)/ PT - Journal Article DEP - 20260130 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12897161 OTO - NOTNLM OT - 24 h movement behaviours OT - PAQ-A OT - accelerometry OT - adolescent cognition OT - physical activity OT - sedentary behaviour OT - sleep COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study, the collection, analysis, or interpretation of data, the writing of the manuscript, or the decision to publish the results. EDAT- 2026/02/13 06:32 MHDA- 2026/02/13 06:33 PMCR- 2026/01/30 CRDT- 2026/02/13 01:05 PHST- 2025/11/27 00:00 [received] PHST- 2025/12/23 00:00 [revised] PHST- 2026/01/28 00:00 [accepted] PHST- 2026/02/13 06:33 [medline] PHST- 2026/02/13 06:32 [pubmed] PHST- 2026/02/13 01:05 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - healthcare14030360 [pii] AID - healthcare-14-00360 [pii] AID - 10.3390/healthcare14030360 [doi] PST - epublish SO - Healthcare (Basel). 2026 Jan 30;14(3):360. doi: 10.3390/healthcare14030360. PMID- 41680433 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Feb 12 TI - Ultrasonographic and cephalometric assessment of tongue thickness across angle's classes of malocclusion in skeletal class I patients. LID - 10.1038/s41598-026-40135-z [doi] LID - 8459 AB - The aim of this study was to investigate the association between tongue thickness and dental malocclusions, to compare the diagnostic reliability of ultrasonography (USG) and lateral cephalometry in tongue assessment, and explore potential sex-related differences in tongue morphology. Ninety participants (54 females, 36 males; mean age: 16.01 +/- 2.26 years) with a skeletal Class I relationship were included and divided into three groups according to Angle's classification: Class I, Class II, and Class III. Tongue thickness measurements were obtained from lateral cephalometric radiographs as cephalometric tongue thickness (CTT) and from USG as ultrasonographic tongue thickness (UTT). Intraobserver reliability was evaluated using Dahlberg's formula and Cronbach's alpha. Statistical analyses included one-way ANOVA, independent-samples t-tests, the Wilcoxon signed-rank test, and Pearson correlation analysis. Statistical significance was set at p < 0.05. Tongue thickness differed significantly among dental malocclusion groups (Class III> Class I > Class II; p < 0.001). For UTT, mean +/- SD values were 35.97 +/- 2.6 mm for Class I, 35.18 +/- 2.2 mm for Class II, and 40.81 +/- 1.9 mm for Class III. For CTT, mean +/- SD values were 34.97 +/- 4.6 mm for Class I, 31.63 +/- 3.1 mm for Class II, and 39.06 +/- 3.4 mm for Class III. UTT showed higher precision and lower variability than CTT (mean absolute difference: 0.32 mm vs. 0.75 mm; p = 0.002). Males had significantly greater tongue thickness than females (p < 0.05). Correlations between CTT and UTT within malocclusion groups were positive but not significant. Tongue thickness is significantly associated with sagittal dental malocclusion. USG provides a reliable and reproducible method for tongue assessment, demonstrating superior precision compared with lateral cephalometry. Incorporating ultrasonographic evaluation of the tongue into orthodontic planning may facilitate individualized treatment strategies and improve the predictability of clinical outcomes. FAU - Aras, Rabia Cayir AU - Aras RC AUID- ORCID: 0000-0002-6910-0507 AD - Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Zonguldak Bulent Ecevit University, Esenkoy, 67600, Kozlu/Zonguldak, Turkey. FAU - Geduk, Gediz AU - Geduk G AUID- ORCID: 0000-0002-9650-2149 AD - Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Zonguldak Bulent Ecevit University, Esenkoy, 67600, Kozlu/Zonguldak, Turkey. gedizgeduk@gmail.com. FAU - Cicek, Orhan AU - Cicek O AUID- ORCID: 0000-0002-8172-6043 AD - Department of Orthodontics, Faculty of Dentistry, Zonguldak Bulent Ecevit University, 67600, Zonguldak, Turkey. LA - eng PT - Journal Article DEP - 20260212 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Male MH - *Cephalometry/methods MH - Ultrasonography/methods MH - *Tongue/diagnostic imaging/pathology MH - Adolescent MH - *Malocclusion, Angle Class I/diagnostic imaging/pathology MH - *Malocclusion/diagnostic imaging/pathology MH - Reproducibility of Results PMC - PMC12972321 OTO - NOTNLM OT - Dental arch OT - Dental malocclusion OT - Lateral cephalometric radiography OT - Tongue thickness OT - Ultrasonography COIS- Declarations. Consent for publication: Patients signed informed consent forms regarding the publication of their data and photographs. Informed consent: Informed consent was obtained from the legal guardians of all participants included in the study. Competing interests: The authors declare no competing interests. EDAT- 2026/02/13 01:27 MHDA- 2026/06/27 06:46 PMCR- 2026/02/12 CRDT- 2026/02/12 23:29 PHST- 2025/07/28 00:00 [received] PHST- 2026/02/10 00:00 [accepted] PHST- 2026/06/27 06:46 [medline] PHST- 2026/02/13 01:27 [pubmed] PHST- 2026/02/12 23:29 [entrez] PHST- 2026/02/12 00:00 [pmc-release] AID - 10.1038/s41598-026-40135-z [pii] AID - 40135 [pii] AID - 10.1038/s41598-026-40135-z [doi] PST - epublish SO - Sci Rep. 2026 Feb 12;16(1):8459. doi: 10.1038/s41598-026-40135-z. PMID- 41679965 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1552-4167 (Electronic) IS - 0145-4455 (Linking) VI - 50 IP - 3 DP - 2026 May TI - Cross-Cultural Adaptation, Validation, and Factor Analysis of a Persian Version of the Behavioral Pediatric Feeding Assessment Scale. PG - 192-211 LID - 10.1177/01454455261416517 [doi] AB - Feeding disorders in early childhood involve maladaptive mealtime behaviors, nutritional deficits, and strained parent-child interactions. Standardized tools for Persian-speaking populations are scarce. This study translated and adapted the Behavioral Pediatrics Feeding Assessment Scale (BPFAS) into Persian and evaluated its psychometric properties. The process included translation/adaptation and psychometric testing. Content validity was reviewed by 14 experts, face validity by interviews with 25 mothers, and construct validity via factor analysis with 203 mothers. Reliability was assessed through internal consistency and test-retest stability. Interviews refined the questionnaire format. Factor analysis yielded five child subscales and three parent subscales, explaining 45.11% and 56.72% of variance. The scale demonstrated strong reliability (Cronbach's alpha = .94; ICC = 0.94). Findings confirm that the Persian BPFAS is a reliable and valid tool for assessing feeding disorders in children in Persian-speaking families. Its multidimensional factor structure highlights the complexity of feeding problems and supports its use for early identification and behavioral intervention planning in clinical and community settings. FAU - Parvizi, Soheila AU - Parvizi S AD - Isfahan University of Medical Sciences, Iran. FAU - Jokar, Fariba AU - Jokar F AD - Isfahan University of Medical Sciences, Iran. FAU - Ostadi, Marziyeh AU - Ostadi M AD - Isfahan University of Medical Sciences, Iran. AD - University of Wisconsin-Madison, USA. FAU - Poorjavad, Marziyeh AU - Poorjavad M AUID- ORCID: 0000-0003-4066-4971 AD - Isfahan University of Medical Sciences, Iran. LA - eng PT - Journal Article PT - Validation Study DEP - 20260212 PL - United States TA - Behav Modif JT - Behavior modification JID - 7803043 SB - IM MH - Humans MH - Psychometrics MH - Factor Analysis, Statistical MH - Reproducibility of Results MH - Female MH - Iran MH - Child, Preschool MH - *Feeding and Eating Disorders of Childhood/diagnosis MH - Male MH - Surveys and Questionnaires MH - Cross-Cultural Comparison MH - Child MH - *Feeding Behavior/psychology OTO - NOTNLM OT - behavioral assessment OT - feeding disorders OT - parent-child interaction OT - pediatric OT - psychometrics OT - validation COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/02/13 01:27 MHDA- 2026/04/10 12:59 CRDT- 2026/02/12 21:32 PHST- 2026/04/10 12:59 [medline] PHST- 2026/02/13 01:27 [pubmed] PHST- 2026/02/12 21:32 [entrez] AID - 10.1177/01454455261416517 [doi] PST - ppublish SO - Behav Modif. 2026 May;50(3):192-211. doi: 10.1177/01454455261416517. Epub 2026 Feb 12. PMID- 41679912 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261022 IS - 2047-6310 (Electronic) IS - 2047-6302 (Print) IS - 2047-6302 (Linking) VI - 21 IP - 2 DP - 2026 Feb TI - Predicting Weight Outcomes From Obesity Medications in a Paediatric Population. PG - e70089 LID - 10.1111/ijpo.70089 [doi] AB - INTRODUCTION: There are limited paediatric studies comparing outcomes from different obesity medications (OMs) in real-world settings. The aim of this study is to describe real-world variability in outcomes and develop models to predict outcomes from OMs. METHODS: We examined electronic health record (EHR) data of patients (12-21 years) with obesity and without diabetes dispensed an OM from 2003 to 2025 in a paediatric healthcare system. We determined percent change in BMI percentile above the 95th percentile (%BMI(p95)) and for patients dispensed the medication >/= 6 months (to allow for a therapeutic dose) used a >/= 5% reduction in %BMI(p95) as the outcome for Catboost gradient-boosting machine learning. We included patient (socio-demographics, baseline %BMI(p95), comorbidities, medications) and treatment (dose, duration, adherence, specialty visits) factors as predictors. RESULTS: A total of 595 patients were included (20% Hispanic, 27% Black, 49% public insurance, 62% with severe obesity). For patients dispensed Liraglutide, Phentermine, Phentermine/Topiramate and Semaglutide > 12 months (comparable duration to clinical trials), average percentage change in %BMI(p95) was 8.76, 10.90, 9.34 and 12.87, and 64%-80% had a >/= 5% final %BMI(p95) reduction. Predictive models demonstrated AUROC >/= 0.75. OM duration, baseline %BMI(p95) and number of specialty visits were associated. CONCLUSIONS: The OMs studied had similar outcomes, with Semaglutide demonstrating slightly better outcomes, but not all patients had successful outcomes. Predictive models can inform clinical decision-making about OMs based on individual characteristics. Future studies validating models prospectively are needed. CI - (c) 2026 World Obesity Federation. FAU - Mottalib, Md Mozaharul AU - Mottalib MM AUID- ORCID: 0000-0003-4930-0365 AD - Department of Computer and Information Sciences, University of Delaware, Newark, Delaware, USA. FAU - Beheshti, Rahmatollah AU - Beheshti R AUID- ORCID: 0000-0001-8912-3063 AD - Department of Computer and Information Sciences, University of Delaware, Newark, Delaware, USA. AD - Department of Biomedical Research, Nemours Children's Health, Wilmington, Delaware, USA. FAU - Viswanathan, Karthik AU - Viswanathan K AD - Department of Biomedical Research, Nemours Children's Health, Wilmington, Delaware, USA. FAU - Bunnell, H Timothy AU - Bunnell HT AD - Department of Biomedical Research, Nemours Children's Health, Wilmington, Delaware, USA. FAU - Phan, Thao-Ly T AU - Phan TT AD - Department of Biomedical Research, Nemours Children's Health, Wilmington, Delaware, USA. AD - Department of Pediatrics, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. LA - eng GR - P20GM144270/GM/NIGMS NIH HHS/United States GR - RI-CHOP-01-PS1/PCORI/Patient-Centered Outcomes Research Institute/United States GR - UG1 HD090915/HD/NICHD NIH HHS/United States GR - UG1OD090915/NIH Office of the Director/ GR - P20 GM144270/GM/NIGMS NIH HHS/United States GR - U54GM10491/GM/NIGMS NIH HHS/United States PT - Journal Article PT - Observational Study PL - England TA - Pediatr Obes JT - Pediatric obesity JID - 101572033 RN - 839I73S42A (Liraglutide) RN - C045TQL4WP (Phentermine) RN - 0H73WJJ391 (Topiramate) RN - 53AXN4NNHX (Semaglutide) RN - 0 (Anti-Obesity Agents) RN - 0 (Hypoglycemic Agents) SB - IM MH - Humans MH - Male MH - Female MH - Child MH - Adolescent MH - Young Adult MH - Treatment Outcome MH - *Pediatric Obesity/complications/drug therapy MH - Diabetes Mellitus MH - *Diabetes Complications/complications/drug therapy MH - Liraglutide/therapeutic use MH - Phentermine/therapeutic use MH - Topiramate/therapeutic use MH - Semaglutide/therapeutic use MH - Body Mass Index MH - Electronic Health Records MH - *Predictive Learning Models MH - *Weight Loss/drug effects MH - *Anti-Obesity Agents/therapeutic use MH - *Hypoglycemic Agents/therapeutic use MH - Prediction Algorithms PMC - PMC13450681 MID - NIHMS2200490 OTO - NOTNLM OT - electronic health record OT - machine learning OT - obesity medications OT - paediatric obesity COIS- Conflicts of Interest The authors declare no conflicts of interest. EDAT- 2026/02/13 01:26 MHDA- 2026/02/13 01:27 PMCR- 2026/08/07 CRDT- 2026/02/12 21:03 PHST- 2025/12/31 00:00 [revised] PHST- 2025/06/02 00:00 [received] PHST- 2026/01/23 00:00 [accepted] PHST- 2026/02/13 01:27 [medline] PHST- 2026/02/13 01:26 [pubmed] PHST- 2026/02/12 21:03 [entrez] PHST- 2026/08/07 00:00 [pmc-release] AID - 10.1111/ijpo.70089 [doi] PST - ppublish SO - Pediatr Obes. 2026 Feb;21(2):e70089. doi: 10.1111/ijpo.70089. PMID- 41679752 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2150-1327 (Electronic) IS - 2150-1319 (Print) IS - 2150-1319 (Linking) VI - 17 DP - 2026 Jan-Dec TI - Translation and Validation of English Version of Screen Dependency Scale (SDS) Among Preschool Children. PG - 21501319261419940 LID - 10.1177/21501319261419940 [doi] LID - 21501319261419940 AB - The Screen Dependency Scale (SDS) is a parent-report tool designed to assess screen media dependency in preschool children which was originally developed in Malay within the Malaysian community. This study aimed to translate and validate the English version of the Screen Dependency Scale (SDS) to enable broader participation, particularly in urban areas where English is widely used. Phase 1 involved forward and backward translation by 2 language experts. An addiction specialist reviewed the back-translated version against the original followed by Face Validity by 14 parents. Phase 2 consisted of a cross-sectional study involving 195 parents of children aged 4 to 6 years. Construct validity was tested using exploratory factor analysis (EFA) followed by confirmatory factor analysis (CFA). CFA showed all items had factor loadings of 0.50 or higher. Model fit indices (RMSEA = 0.08; CFI = 0.92) indicated a good fit. The English SDS demonstrated excellent internal consistency (Cronbach's alpha = .89). Thus, the English version is a valid and reliable tool for assessing screen dependency in Malaysian preschoolers. FAU - Abdul Hadi, Azwanis AU - Abdul Hadi A AUID- ORCID: 0000-0002-1624-0821 AD - International Islamic University Malaysia, Kuantan, Pahang, Malaysia. FAU - Zainoren, Nadirah AU - Zainoren N AD - International Islamic University Malaysia, Kuantan, Pahang, Malaysia. FAU - Said, Abdul Hadi AU - Said AH AUID- ORCID: 0000-0001-8726-9464 AD - International Islamic University Malaysia, Kuantan, Pahang, Malaysia. FAU - Zainal Abidin, Muhammad 'Adil AU - Zainal Abidin M' AUID- ORCID: 0000-0001-6108-1180 AD - International Islamic University Malaysia, Kuantan, Pahang, Malaysia. LA - eng PT - Journal Article PT - Validation Study DEP - 20260212 PL - United States TA - J Prim Care Community Health JT - Journal of primary care & community health JID - 101518419 SB - IM MH - Humans MH - Malaysia MH - Child, Preschool MH - Psychometrics MH - Reproducibility of Results MH - Cross-Sectional Studies MH - Factor Analysis, Statistical MH - Female MH - Male MH - Child MH - Surveys and Questionnaires/standards MH - Translations MH - Parents MH - *Screen Time MH - *Internet Addiction Disorder/diagnosis PMC - PMC12901900 OTO - NOTNLM OT - English translation OT - Malaysia OT - Screen Dependency Scale (SDS) OT - parent-report questionnaire OT - preschool children OT - psychometric validation OT - screen dependency OT - screen time COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/02/13 01:27 MHDA- 2026/02/13 01:28 PMCR- 2026/02/12 CRDT- 2026/02/12 19:53 PHST- 2026/02/13 01:28 [medline] PHST- 2026/02/13 01:27 [pubmed] PHST- 2026/02/12 19:53 [entrez] PHST- 2026/02/12 00:00 [pmc-release] AID - 10.1177_21501319261419940 [pii] AID - 10.1177/21501319261419940 [doi] PST - ppublish SO - J Prim Care Community Health. 2026 Jan-Dec;17:21501319261419940. doi: 10.1177/21501319261419940. Epub 2026 Feb 12. PMID- 41679234 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1532-1983 (Electronic) IS - 0261-5614 (Linking) VI - 58 DP - 2026 Mar TI - Design and validation of kineanthropometric measurement protocols in adult population with cerebral palsy. PG - 106572 LID - S0261-5614(25)00352-8 [pii] LID - 10.1016/j.clnu.2025.106572 [doi] AB - BACKGROUND & AIMS: Adults with cerebral palsy (CP) face a high risk of malnutrition, yet most nutritional assessment methods have been developed for children. Despite the known anatomical and functional heterogeneity in adults with CP, there is a lack of validated, adapted tools for this population. This study aims to design and validate a specific anthropometric method for assessing the nutritional status of adults with CP, addressing this critical gap in clinical and research practice. METHODS: This cross-sectional study consisted of two phases. First, anthropometric measurements were performed on 47 adults with CP to identify practical challenges and design an adapted protocol. In the second phase, this protocol was applied to 74 healthy adults trained to simulate the postural limitations commonly observed in individuals with CP (e.g., asymmetries, spasticity-related contractures), based on direct observation in the CP group. Measurements obtained with the adapted method were statistically compared to those obtained using the International Society for the Advancement of Kinanthropometry (ISAK) reference protocol. RESULTS: The adapted protocol accounts for the anatomical and functional challenges of individuals with CP by allowing measurements to be performed in a supine position or with limbs flexed or extended, as necessary. Statistical analysis revealed no significant differences between the adapted protocol and the ISAK reference method for any of the anthropometric measurements. These results confirm that the modified approach yields accurate and reliable assessments of nutritional status in adults with CP. CONCLUSION: The anatomical and functional limitations of adults with CP present significant challenges to traditional ISAK methodology. However, the adapted protocol, performed in a supine position by trained anthropometrists, produces comparable results. Key indicators such as Arm Muscle Area, Arm Adipose Area, and the Adipose-Muscular Index can reliably assess the nutritional status of this population, offering a viable alternative for clinical and research applications.. CI - Copyright (c) 2026 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Exposito, David AU - Exposito D AD - Department of Preventive Medicine, University of Valencia, Faculty of Pharmacy and Food Sciences, Burjassot, Valencia, 46100, Spain; Department of Nutrition, Universidad Catolica de Valencia, Faculty of Medicine and Health Sciences Valencia, Valencia, 46001 Spain; Department of Physiotherapy, Universidad Europea de Valencia, Faculty of Health Sciences, Valencia, 46010, Spain. Electronic address: Carla.soler@uv.es. FAU - Soriano, Jose Miguel AU - Soriano JM AD - Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics UV-IIS La Fe, Valencia, 46012, Spain; Food&Health Lab, Instituto de Ciencias de los Materiales, Universitat de Valencia, Paterna, Valencia, 46980 Spain. FAU - Soler, Carla AU - Soler C AD - Department of Preventive Medicine, University of Valencia, Faculty of Pharmacy and Food Sciences, Burjassot, Valencia, 46100, Spain; Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics UV-IIS La Fe, Valencia, 46012, Spain. LA - eng PT - Journal Article PT - Validation Study DEP - 20260102 PL - England TA - Clin Nutr JT - Clinical nutrition (Edinburgh, Scotland) JID - 8309603 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology/complications MH - Adult MH - Male MH - Female MH - *Nutrition Assessment MH - *Anthropometry/methods MH - Cross-Sectional Studies MH - Nutritional Status MH - Young Adult MH - Reproducibility of Results MH - Middle Aged MH - Malnutrition/diagnosis/etiology OTO - NOTNLM OT - Body composition measurements OT - Cerebral palsy OT - Kinanthropometry OT - Nutritional assessment COIS- Conflict of interest All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript. EDAT- 2026/02/13 01:27 MHDA- 2026/03/06 13:44 CRDT- 2026/02/12 18:09 PHST- 2025/03/31 00:00 [received] PHST- 2025/12/22 00:00 [revised] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/03/06 13:44 [medline] PHST- 2026/02/13 01:27 [pubmed] PHST- 2026/02/12 18:09 [entrez] AID - S0261-5614(25)00352-8 [pii] AID - 10.1016/j.clnu.2025.106572 [doi] PST - ppublish SO - Clin Nutr. 2026 Mar;58:106572. doi: 10.1016/j.clnu.2025.106572. Epub 2026 Jan 2. PMID- 41679230 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1476-5616 (Electronic) IS - 0033-3506 (Linking) VI - 253 DP - 2026 Apr TI - The associations of maternal exposure to PM(1) during pregnancy with emotional and behavioral problems in offspring: The interaction effect of maternal diet. PG - 106195 LID - S0033-3506(26)00064-8 [pii] LID - 10.1016/j.puhe.2026.106195 [doi] AB - OBJECTIVES: We aimed to examine the association between PM(1) exposure during different stages of pregnancy and emotional and behavioral problems in offspring, and to evaluate whether maternal diet quality interacts with these relationships. STUDY DESIGN: Birth cohort study. METHODS: This cohort study included 391 mother-child pairs from Guangzhou, China. Prenatal PM(1) exposure was estimated using a spatiotemporal model. Maternal diet was assessed via a validated food frequency questionnaire and scored using the Chinese Healthy Eating Index (CHEI). At age 5, offspring's emotional and behavioral problems were evaluated with the Strengths and Difficulties Questionnaire, including emotional, conduct, hyperactivity, peer relationship problems, prosocial behavior, and total difficulties. Generalized linear models were used to examine the association. RESULTS: Overall, 15.9% of children exhibited at least one type of emotional and behavioral problem. The mean maternal PM(1) was 17.51 +/- 2.38 mug/m(3). Each interquartile range (IQR) increase in PM(1) concentration during the first trimester was associated with elevated risk of offspring behavioral problems (OR = 2.25; 95% CI: 1.06 approximately 4.89). Increased PM(1) exposure during both the first (OR = 2.90; 1.07 approximately 8.21) and second trimesters (OR = 4.50; 1.23 approximately 16.76) was linked to higher odds of total difficulties. Higher maternal CHEI scores, particularly the total score and dark vegetable intake component, were associated with weaker PM(1)-related associations. CONCLUSION: Maternal exposure to PM(1) during pregnancy, especially during the first and second trimesters, was associated with an increased risk of emotional and behavioral problems in offspring. A high-quality maternal diet, particularly one rich in vegetables, may mitigate these adverse effects. CI - Copyright (c) 2026 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved. FAU - Li, Mengfan AU - Li M AD - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. FAU - Zhang, Guoyu AU - Zhang G AD - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. FAU - He, Xuanqing AU - He X AD - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. FAU - Gu, Xiaonan AU - Gu X AD - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. FAU - Zhuang, Weiyin AU - Zhuang W AD - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. FAU - Wang, Chang AU - Wang C AD - Experimental Teaching Center, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. FAU - Liu, Yu AU - Liu Y AD - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. FAU - Liu, Shun AU - Liu S AD - Department of Maternal, Child and Adolescent Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, People's Republic of China. FAU - Wang, Xin AU - Wang X AD - Key Laboratory of Brain, Cognition and Education Sciences, Ministry of Education, Institute for Brain Research and Rehabilitation, and Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, Guangzhou, Guangdong，, People's Republic of China. FAU - Wang, Zhen AU - Wang Z AD - Department of Science and Education, Shenzhen Birth Cohort Study Center, Nanshan Maternity and Child Healthcare Hospital of Shenzhen, Shenzhen, Guangdong, People's Republic of China. FAU - Cai, Li AU - Cai L AD - Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China; Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou, Guangdong, People's Republic of China. Electronic address: caili5@mail.sysu.edu.cn. LA - eng PT - Journal Article DEP - 20260211 PL - Netherlands TA - Public Health JT - Public health JID - 0376507 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Prenatal Exposure Delayed Effects/epidemiology MH - China/epidemiology MH - *Diet/statistics & numerical data MH - Child, Preschool MH - Adult MH - *Maternal Exposure/adverse effects MH - *Problem Behavior MH - Birth Cohort MH - *Child Behavior Disorders/epidemiology MH - Cohort Studies OTO - NOTNLM OT - Children OT - Diet OT - Emotional and behavioral problems OT - PM(1) OT - Pregnancy COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/02/13 01:27 MHDA- 2026/03/20 00:59 CRDT- 2026/02/12 18:09 PHST- 2025/10/09 00:00 [received] PHST- 2026/01/23 00:00 [revised] PHST- 2026/02/06 00:00 [accepted] PHST- 2026/03/20 00:59 [medline] PHST- 2026/02/13 01:27 [pubmed] PHST- 2026/02/12 18:09 [entrez] AID - S0033-3506(26)00064-8 [pii] AID - 10.1016/j.puhe.2026.106195 [doi] PST - ppublish SO - Public Health. 2026 Apr;253:106195. doi: 10.1016/j.puhe.2026.106195. Epub 2026 Feb 11. PMID- 41678982 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260927 IS - 1872-7123 (Electronic) IS - 0165-1781 (Linking) VI - 358 DP - 2026 Apr TI - Mindfulness-based therapy for adolescent internet gaming disorder: A feasibility and pilot study. PG - 116990 LID - S0165-1781(26)00051-X [pii] LID - 10.1016/j.psychres.2026.116990 [doi] AB - Internet Gaming Disorder (IGD) is prevalent in adolescents and is treatable. Mindfulness-based therapy can benefit addictive behaviors, craving, and emotion regulation. However, evidence on its effectiveness in treating IGD is still lacking. This study aims to test its feasibility and effectiveness in adolescents with IGD. In total, 23 secondary school students finished the 4-week group-based intervention. At posttest, participants reported significantly lower levels of IGD symptoms (mean difference=1.13), craving (mean difference=0.38), and higher levels of emotion regulation (mean difference=-6.91) compared with pre-test. In general, participants rated the intervention positively. The response summary to the open-ended question indicated that participants favored the in-session mindfulness exercises. Suggestions to improve the intervention design were also provided. The current intervention is low cost and time-efficient with high completion rates and acceptability in adolescents with IGD. Future work may further adopt randomized control trial designs and explore the long-term effects of mindfulness-based interventions for IGD. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Yang, Xue AU - Yang X AD - The Jockey Club School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR China. Electronic address: sherryxueyang@cuhk.edu.hk. FAU - Zheng, Yalin AU - Zheng Y AD - Beijing Key Lab of TCM Collateral Disease Theory Research, School of Traditional Chinese Medicine, Capital Medical University, Beijing, China. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260202 PL - Ireland TA - Psychiatry Res JT - Psychiatry research JID - 7911385 SB - IM MH - Humans MH - Adolescent MH - *Mindfulness/methods MH - *Internet Addiction Disorder/therapy/psychology MH - Female MH - Pilot Projects MH - Male MH - Feasibility Studies MH - *Emotional Regulation/physiology MH - Internet MH - *Video Games MH - Treatment Outcome OTO - NOTNLM OT - Adolescents OT - Emotion regulation OT - Internet gaming disorder OT - Mindfulness-based therapy COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/02/13 01:27 MHDA- 2026/02/20 00:32 CRDT- 2026/02/12 18:04 PHST- 2025/08/18 00:00 [received] PHST- 2026/01/28 00:00 [revised] PHST- 2026/02/01 00:00 [accepted] PHST- 2026/02/20 00:32 [medline] PHST- 2026/02/13 01:27 [pubmed] PHST- 2026/02/12 18:04 [entrez] AID - S0165-1781(26)00051-X [pii] AID - 10.1016/j.psychres.2026.116990 [doi] PST - ppublish SO - Psychiatry Res. 2026 Apr;358:116990. doi: 10.1016/j.psychres.2026.116990. Epub 2026 Feb 2. PMID- 41678855 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260920 IS - 1094-6950 (Print) IS - 1094-6950 (Linking) VI - 29 IP - 2 DP - 2026 Apr-Jun TI - Visceral adipose tissue in obesity: A comparison between DXA and MRI measures. PG - 101679 LID - S1094-6950(26)00013-2 [pii] LID - 10.1016/j.jocd.2026.101679 [doi] AB - While magnetic resonance imaging (MRI) accurately measures visceral adipose tissue (VAT), it is costly and time-consuming. Dual X-ray absorptiometry (DXA) offers a faster, more affordable alternative. However, prior comparisons between DXA and MRI often involve different anatomical locations, limiting accuracy assessments. This study aims to compare VAT volume measurements from DXA and MRI at the same anatomical location (L3 vertebra). We hypothesized that both methods would yield similar VAT results. Methodology This is a retrospective, cross-sectional study that analyzed 50 pairs of matched MRI and DXA scans from 28 non-diabetic participants with obesity (18-65 years, BMI range of >/=30 to /=95th percentile) and their parents (n=15). Focus groups identified digital, health education, and support needs. An expert and community panel assisted in developing solutions based on these findings. A sample content session with a food tasting experience was created and reviewed by participants. The research team subsequently built a digital platform to host the content. Participants assessed the usability of the platform, including the ease of use, design components, and technical issues. A second meeting of the expert panel provided recommendations for further refinement and feedback. RESULTS: Findings from focus groups indicated that most participants (31/36, 86.1%) reported stable internet access and multiple digital devices. With regard to format, a few parents (2/9, 22.2%) preferred synchronous content sessions, while most youth and parents favored asynchronous sessions (7/9, 77.8%) lasting 40 to 60 minutes. Health education needs included interactive content, healthy recipes, and the ability to ask questions. Experts suggested offering asynchronous sessions with monthly synchronous meetings to meet both parent and youth needs. After viewing a sample session, families found the content easy to understand and mostly engaging, with (17/21) 81% participating in the food tasting activity and all participants reporting that the activity was feasible. Experts recommended using a more conversational, interactive teaching style to improve the content and using a food box with nonperishable items to increase the ease of food tasting activities. While the digital platform was functional and easy to use, families highlighted the need for larger font and icon sizes, easier navigation, and better color contrasts. On the basis of this feedback, experts advised creating tutorial videos and an orientation session for platform training. The content and platform will continue to be refined before further evaluation in a 12-week feasibility pilot study. CONCLUSIONS: The use of a co-design approach provided opportunities to make content more interactive and engaging and to increase the ease of use of the digital platform. Describing the adaptation process using a guiding framework in collaboration with the focus population will inform future studies aiming to adapt evidence-based interventions to a digital platform. CI - (c) Sandra Mihail, Marbelly Partida, Lizette Villanueva, Debbe Thompson, Teresia M O'Connor, Salma M Musaad, Maria J Redondo, Erica G Soltero. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Mihail, Sandra AU - Mihail S AUID- ORCID: 0000-0003-0511-7104 AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates St., Houston, TX, 77030, United States, 1 713-798-7154. FAU - Partida, Marbelly AU - Partida M AUID- ORCID: 0009-0006-0608-6230 AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates St., Houston, TX, 77030, United States, 1 713-798-7154. FAU - Villanueva, Lizette AU - Villanueva L AUID- ORCID: 0009-0006-6451-8118 AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates St., Houston, TX, 77030, United States, 1 713-798-7154. FAU - Thompson, Debbe AU - Thompson D AUID- ORCID: 0000-0002-5491-8816 AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates St., Houston, TX, 77030, United States, 1 713-798-7154. FAU - O'Connor, Teresia M AU - O'Connor TM AUID- ORCID: 0000-0002-3231-8481 AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates St., Houston, TX, 77030, United States, 1 713-798-7154. FAU - Musaad, Salma M AU - Musaad SM AUID- ORCID: 0000-0003-1733-830X AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates St., Houston, TX, 77030, United States, 1 713-798-7154. FAU - Redondo, Maria J AU - Redondo MJ AUID- ORCID: 0000-0001-5871-4645 AD - Division of Pediatric Diabetes and Endocrinology, Department of Pediatrics, Baylor College of Medicine, Houston, TX, United States. FAU - Soltero, Erica G AU - Soltero EG AUID- ORCID: 0000-0002-7202-9262 AD - USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, 1100 Bates St., Houston, TX, 77030, United States, 1 713-798-7154. LA - eng GR - 58-3092-0-001/Department of Agriculture/Agricultural Research Service/ GR - K01 DK102868/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20260211 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Adolescent MH - Humans MH - Male MH - Community-Based Participatory Research MH - *Diabetes Mellitus/prevention & control MH - *Digital Health MH - Digital Media MH - Focus Groups MH - *Health Education/methods MH - *Hispanic or Latino/psychology/statistics & numerical data MH - *Obesity/ethnology PMC - PMC12893523 OTO - NOTNLM OT - DM OT - Hispanic health OT - adolescents OT - diabetes OT - diabetes mellitus OT - diabetes prevention OT - digital devices OT - digital education OT - digital health OT - digital health intervention OT - digital platform OT - disease prevention OT - endocrinology OT - evidence-based interventions OT - family-based intervention OT - feasibility pilot study OT - obesity OT - type 1 diabetes OT - type 2 diabetes COIS- Conflicts of Interest: None declared. EDAT- 2026/02/11 18:59 MHDA- 2026/02/11 19:00 PMCR- 2026/02/11 CRDT- 2026/02/11 15:13 PHST- 2024/10/21 00:00 [received] PHST- 2025/12/12 00:00 [revised] PHST- 2025/12/16 00:00 [accepted] PHST- 2026/02/11 19:00 [medline] PHST- 2026/02/11 18:59 [pubmed] PHST- 2026/02/11 15:13 [entrez] PHST- 2026/02/11 00:00 [pmc-release] AID - v10i1e67800 [pii] AID - 67800 [pii] AID - 10.2196/67800 [doi] PST - epublish SO - JMIR Form Res. 2026 Feb 11;10:e67800. doi: 10.2196/67800. PMID- 41670948 OWN - NLM STAT- Publisher LR - 20260211 IS - 1753-4887 (Electronic) IS - 0029-6643 (Linking) DP - 2026 Feb 11 TI - Association Between Diet and Metabolome in Childhood and Adolescence: A Systematic Review. LID - nuaf305 [pii] LID - 10.1093/nutrit/nuaf305 [doi] AB - CONTEXT: Accurately assessing dietary intake in children and adolescents is challenging due to the limitations of traditional self-reported methods. Metabolomics has emerged as a valuable tool for assessing the body's biochemical response to specific foods, food groups, or dietary patterns, thereby improving the evaluation of diet-health relationships. However, evidence on how diet influences metabolomic profiles in pediatric populations remains limited. OBJECTIVE: To evaluate the evidence on the relationship between nutritional interventions or habitual dietary intake and metabolites measured in blood or urine among children and adolescents. DATA SOURCES: A systematic search was conducted in PubMed, Cochrane, and Embase databases up to September 2024. DATA EXTRACTION: This systematic review was conducted in accordance with the principles of the Cochrane Collaboration, and PRISMA guidelines were followed. Randomized clinical trials and observational studies in children and adolescents were included. DATA ANALYSIS: From 659 records, 8 studies met the inclusion criteria, involving 5992 participants across 12 countries. The included studies reported associations across 3 dietary categories: dietary patterns, food groups, and specific food ingredients. Both targeted and untargeted metabolomic analyses were used to identify diet-related biomarkers in blood and urine. Positive associations were observed between higher adherence to the Mediterranean diet and greater fruit and vegetable consumption with metabolites such as hippurate, trigonelline, and proline betaine. In contrast, higher intake of ultra-processed foods and adherence to vegan diets were inversely associated with branched-chain amino acids and aromatic amino acids such as tyrosine and docosahexaenoic acid. CONCLUSION: This review identifies several metabolites consistently associated with specific dietary components across different studies in children and adolescents. These findings support the potential of metabolomics for validating dietary biomarkers and improving the accuracy of dietary assessment in pediatric populations. Although metabolomic markers reflect actual dietary intake, their implications for health outcomes remain to be explored. SYSTEMATIC REVIEW REGISTRATION: PROSPERO registration no. CRD42024506437. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the International Life Sciences Institute. FAU - Gispert-Llaurado, Mariona AU - Gispert-Llaurado M AUID- ORCID: 0000-0002-4586-8079 AD - Pediatrics, Nutrition and Development Research Unit, Universitat Rovira i Virgili (URV), Reus, 43201, Spain. AD - Pediatrics, Nutrition and Development Research Unit, Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, 43201, Spain. FAU - Gheorghita, Irina AU - Gheorghita I AUID- ORCID: 0000-0003-1222-4039 AD - Pediatrics, Nutrition and Development Research Unit, Universitat Rovira i Virgili (URV), Reus, 43201, Spain. AD - Pediatrics, Nutrition and Development Research Unit, Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, 43201, Spain. FAU - Vehovec, Lara AU - Vehovec L AUID- ORCID: 0009-0000-0613-6820 AD - Institute of Computational Biology, Helmholtz Zentrum Munchen-German Research Center for Environmental Health, Neuherberg, 85764, Germany. FAU - Ferre, Natalia AU - Ferre N AUID- ORCID: 0000-0002-2838-1525 AD - Pediatrics, Nutrition and Development Research Unit, Universitat Rovira i Virgili (URV), Reus, 43201, Spain. AD - Pediatrics, Nutrition and Development Research Unit, Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, 43201, Spain. FAU - Ramirez, Noelia AU - Ramirez N AUID- ORCID: 0000-0002-9251-0790 AD - Pediatrics, Nutrition and Development Research Unit, Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, 43201, Spain. FAU - Horak, Jeannie AU - Horak J AUID- ORCID: 0000-0002-0873-9358 AD - Department of Pediatrics, Dr von Hauner Children's Hospital, LMU Munich, Munich, 80337, Germany. AD - German Center for Child and Adolescent Health, Munich, 80337, Germany. FAU - Demmelmair, Hans AU - Demmelmair H AUID- ORCID: 0000-0001-7812-5178 AD - Department of Pediatrics, Dr von Hauner Children's Hospital, LMU Munich, Munich, 80337, Germany. AD - German Center for Child and Adolescent Health, Munich, 80337, Germany. FAU - Patro-Golab, Bernadeta AU - Patro-Golab B AUID- ORCID: 0000-0003-0922-2921 AD - Department of Pediatrics, Dr von Hauner Children's Hospital, LMU Munich, Munich, 80337, Germany. AD - German Center for Child and Adolescent Health, Munich, 80337, Germany. FAU - Grote, Veit AU - Grote V AUID- ORCID: 0000-0001-7168-2385 AD - Department of Pediatrics, Dr von Hauner Children's Hospital, LMU Munich, Munich, 80337, Germany. AD - German Center for Child and Adolescent Health, Munich, 80337, Germany. FAU - Koletzko, Berthold AU - Koletzko B AUID- ORCID: 0000-0002-5345-7165 AD - Department of Pediatrics, Dr von Hauner Children's Hospital, LMU Munich, Munich, 80337, Germany. AD - German Center for Child and Adolescent Health, Munich, 80337, Germany. FAU - Kastenmuller, Gabi AU - Kastenmuller G AUID- ORCID: 0000-0002-2368-7322 AD - Institute of Computational Biology, Helmholtz Zentrum Munchen-German Research Center for Environmental Health, Neuherberg, 85764, Germany. FAU - Kratochwill, Klaus AU - Kratochwill K AUID- ORCID: 0000-0003-0803-614X AD - Core Facility Proteomics, Medical University of Vienna, Vienna, 1090, Austria. AD - Division of Pediatric Nephrology and Gastroenterology, Department of Pediatrics and Adolescent Medicine, Comprehensive Center for Pediatrics, Medical University of Vienna, Vienna, 1090, Austria. FAU - Verduci, Elvira AU - Verduci E AUID- ORCID: 0000-0003-2111-3111 AD - Department of Pediatrics, Vittore Buzzi Children's Hospital, Metabolic Disease Unit, University of Milan, Milan, 20154, Italy. AD - Department of Health Sciences, University of Milan, Milan, 20142, Italy. FAU - Gruszfeld, Dariusz AU - Gruszfeld D AUID- ORCID: 0000-0002-2414-4928 AD - Neonatal Department, Children's Memorial Health Institute, Warsaw, 04-730, Poland. FAU - Escribano, Joaquin AU - Escribano J AUID- ORCID: 0000-0002-5041-459X AD - Pediatrics, Nutrition and Development Research Unit, Universitat Rovira i Virgili (URV), Reus, 43201, Spain. AD - Pediatrics, Nutrition and Development Research Unit, Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, 43201, Spain. FAU - Luque, Veronica AU - Luque V AUID- ORCID: 0000-0003-2615-8175 AD - Pediatrics, Nutrition and Development Research Unit, Universitat Rovira i Virgili (URV), Reus, 43201, Spain. AD - Pediatrics, Nutrition and Development Research Unit, Institut de Recerca Biomedica Catalunya Sud (IRBCatSud), Reus, 43201, Spain. LA - eng GR - ERA-NET Cofund action number 727565, JPI-HDHL-INTIMIC 2021/European Union's Horizon 2020 Research and Innovation Programme/ GR - AC21_2/00010 (IISPV)/Instituto de Salud Carlos III (ISCIII) and Next Generation EU funds for actions of the Recovery, Transformation and Resilience Plan (PRTR)/ GR - 01EA2203A (LMU) and 01EA2203B (HMGU)/Bundesministerium fur Bildung und Forschung (BMBF)/ GR - FO999890543 (MUV)/Osterreichische Forschungsforderungsgesellschaft mbH (FFG), Bundesministerium fur Frauen, Wissenschaft und Forschung (BMFWF), and the MissionERA program/ GR - 01EA2101 and 01EA2203A/German Ministry of Education and Research, Berlin/ GR - DZKJ, 01GL2406A/German Center for Child and Adolescent Health/ GR - the charitable Else Kroner-Fresenius-Foundation, LMU Medical Faculty, and LMU University Hospitals/ PT - Journal Article DEP - 20260211 PL - United States TA - Nutr Rev JT - Nutrition reviews JID - 0376405 SB - IM OTO - NOTNLM OT - adolescents OT - biomarkers OT - children OT - diet OT - metabolomics EDAT- 2026/02/11 13:07 MHDA- 2026/02/11 13:07 CRDT- 2026/02/11 11:38 PHST- 2026/02/11 13:07 [medline] PHST- 2026/02/11 13:07 [pubmed] PHST- 2026/02/11 11:38 [entrez] AID - 8472671 [pii] AID - 10.1093/nutrit/nuaf305 [doi] PST - aheadofprint SO - Nutr Rev. 2026 Feb 11:nuaf305. doi: 10.1093/nutrit/nuaf305. PMID- 41670733 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260716 IS - 1432-0711 (Electronic) IS - 0932-0067 (Print) IS - 0932-0067 (Linking) VI - 313 IP - 1 DP - 2026 Feb 11 TI - Inflammation at the crossroads of reproduction: SIRI as a prognostic signature of female infertility in hybrid regression-machine learning models. PG - 86 LID - 10.1007/s00404-026-08350-1 [doi] LID - 86 AB - BACKGROUND: Female infertility is a critical global health concern, with a rising prevalence and significant psychosocial consequences. This study aimed to investigate the association between Systemic Inflammatory Response Index (SIRI) and female infertility. METHODS: This cross-sectional study enrolled 3059 reproductive-aged women (18-45 years) to examine the association between SIRI and female infertility using data from the National Health and Nutrition Examination Survey (NHANES) spanning from 2015 to 2020. Multivariable logistic regression generalized additive models (GAM), restricted cubic splines (RCS), and threshold effect analyses were leveraged. Machine learning approaches were also utilized to validate predictive performance and identify key features. RESULTS: Elevated SIRI was independently associated with increased odds of infertility. In the fully adjusted logistic model, each unit increase in SIRI corresponded to a 34% increase in infertility risk (OR 1.34, p = 0.001). Women in the highest SIRI quartile had more than double the odds of infertility compared to those in the lowest quartile (OR 2.08, p < 0.001), with a significant dose-response trend (p trend < 0.001). GAM and RCS models confirmed a monotonic and curvilinear association, respectively. Threshold analysis revealed a critical inflection point at SIRI = 1.66. Machine learning validation identified SIRI as one of the most influential predictors, with XGBoost achieving the highest (AUC = 0.866). CONCLUSION: These findings support the role of chronic systemic inflammation in female infertility and highlight SIRI as a valuable biomarker for risk prediction and clinical assessment. CI - (c) 2026. The Author(s). FAU - Khaksar, Mohammad Ali AU - Khaksar MA AD - Lillehei Heart Institute, University of Minnesota, Minneapolis, MN, 55455, USA. AD - Department of Pediatrics, University of Minnesota, Minneapolis, MN, 55455, USA. FAU - Hosseinpour, Mostafa AU - Hosseinpour M AD - Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. FAU - Bastani, Mohammad-Navid AU - Bastani MN AD - Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. FAU - Mohammadpour Fard, Reza AU - Mohammadpour Fard R AD - Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. FAU - Zahedian, Mehdi AU - Zahedian M AD - Student Research Committee, Iran University of Medical Sciences, Tehran, Iran. AD - Department of Health Information Management, School of Health Management and Information Sciences, Iran University of Medical Sciences, Tehran, Iran. FAU - Mahdizade, Amir Hossein AU - Mahdizade AH AD - Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. FAU - Bahreiny, Seyed Sobhan AU - Bahreiny SS AUID- ORCID: 0000-0003-2148-1205 AD - Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. bahsobi@gmail.com. LA - eng PT - Journal Article DEP - 20260211 PL - Germany TA - Arch Gynecol Obstet JT - Archives of gynecology and obstetrics JID - 8710213 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Adult MH - Cross-Sectional Studies MH - *Inflammation/complications/blood MH - *Infertility, Female/blood/epidemiology/diagnosis MH - *Machine Learning MH - Middle Aged MH - Young Adult MH - Prognosis MH - Adolescent MH - Logistic Models MH - Predictive Learning Models MH - Nutrition Surveys MH - Biomarkers/blood PMC - PMC12894131 OTO - NOTNLM OT - Female infertility OT - Inflammatory biomarker OT - Machine learning OT - NHANES OT - Systemic Inflammation Response Index (SIRI) COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval and consent to participate: All participants submitted written informed consent and were approved by the National Ethics Board. Consent for publication: Not applicable. EDAT- 2026/02/11 13:08 MHDA- 2026/02/11 13:09 PMCR- 2026/02/11 CRDT- 2026/02/11 11:22 PHST- 2025/08/11 00:00 [received] PHST- 2026/01/28 00:00 [accepted] PHST- 2026/02/11 13:09 [medline] PHST- 2026/02/11 13:08 [pubmed] PHST- 2026/02/11 11:22 [entrez] PHST- 2026/02/11 00:00 [pmc-release] AID - 10.1007/s00404-026-08350-1 [pii] AID - 8350 [pii] AID - 10.1007/s00404-026-08350-1 [doi] PST - epublish SO - Arch Gynecol Obstet. 2026 Feb 11;313(1):86. doi: 10.1007/s00404-026-08350-1. PMID- 41670436 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1479-6805 (Electronic) IS - 0022-0795 (Linking) VI - 268 IP - 2 DP - 2026 Feb 1 TI - Utility of next-generation sequencing for the genetic study of MODY diabetes. LID - e250344 [pii] LID - 10.1530/JOE-25-0344 [doi] AB - Next-generation sequencing (NGS) is increasingly used for diagnosing monogenic forms of diabetes, including maturity-onset diabetes of the young (MODY). We aimed to evaluate the utility of NGS in patients with clinical suspicion of MODY, analyzing genotype-phenotype correlations. A total of 150 unrelated patients from the Region of Murcia (Spain) with suspected MODY were included. Whole-exome sequencing was performed and validated with Sanger and multiplex ligation-dependent probe amplification (MLPA). Variants were classified according to the American College of Medical Genetics and Genomics (ACMG) criteria. Relevant clinical data were collected per the American Diabetes Association (ADA) and European Association for the Study of Diabetes (EASD) criteria and analyzed using SPSS v.27.0.2.0. The diagnostic yield was 16.67% (25/150). Pathogenic or likely pathogenic variants were mainly identified in GCK (38.89%) and HNF1A (33.33%). Significant differences were found between patients with and without genetic diagnosis in family history, age of onset, and body mass index (P < 0.05). Variants of uncertain significance (VUS) were identified in 22 families (14.66%). One VUS was reclassified as likely pathogenic, and three were prioritized for further evaluation. NGS is a valuable tool for the genetic diagnosis of MODY. Integration of clinical data and systematic re-evaluation and prioritization of VUS can enhance diagnostic accuracy and inform clinical decision-making. FAU - Exposito Garcia, Marta AU - Exposito Garcia M AUID- ORCID: 0009-0002-6205-6299 AD - Genomics Laboratory, Clinical Analysis Department, Virgen de la Arrixaca University Clinical Hospital, Carretera Madrid-Cartagena, El Palmar, Murcia, Spain. AD - Department of Biochemistry and Molecular Biology B and Immunology, University of Murcia, Murcia, Spain. AD - Clinical Genetics; Hematology and Clinical-Experimental Oncology; Molecular Therapies and Biomarkers of Solid Tumors, Biomedical Research Institute of Murcia "Pascual Parrilla" (IMIB-Arrixaca), Murcia, Spain. FAU - Sarabia Meseguer, Maria Desamparados AU - Sarabia Meseguer MD AD - Genomics Laboratory, Clinical Analysis Department, Virgen de la Arrixaca University Clinical Hospital, Carretera Madrid-Cartagena, El Palmar, Murcia, Spain. AD - Department of Biochemistry and Molecular Biology B and Immunology, University of Murcia, Murcia, Spain. AD - Clinical Genetics; Hematology and Clinical-Experimental Oncology; Molecular Therapies and Biomarkers of Solid Tumors, Biomedical Research Institute of Murcia "Pascual Parrilla" (IMIB-Arrixaca), Murcia, Spain. FAU - Hernandez Martinez, Antonio Miguel AU - Hernandez Martinez AM AD - Endocrinology and Nutrition Department, Virgen de la Arrixaca University Clinical Hospital, Carretera Madrid-Cartagena, El Palmar, Murcia, Spain. FAU - Aragon Alonso, Aurora AU - Aragon Alonso A AD - Endocrinology and Nutrition Department, Virgen de la Arrixaca University Clinical Hospital, Carretera Madrid-Cartagena, El Palmar, Murcia, Spain. FAU - Fernandez Lopez, Manuela AU - Fernandez Lopez M AD - Endocrinology and Nutrition Department, Virgen de la Arrixaca University Clinical Hospital, Carretera Madrid-Cartagena, El Palmar, Murcia, Spain. FAU - Macanas Botia, Gabriel Angel AU - Macanas Botia GA AD - Endocrinology and Nutrition Department, Virgen de la Arrixaca University Clinical Hospital, Carretera Madrid-Cartagena, El Palmar, Murcia, Spain. FAU - Illan Gomez, Maria Fatima AU - Illan Gomez MF AD - Endocrinology and Nutrition Department, Morales Meseguer University Clinical Hospital, Marques de los Velez, Murcia, Spain. FAU - Kyriakos, Georgios AU - Kyriakos G AD - Endocrinology and Nutrition Department, Santa Lucia University Clinical Hospital, Mezquita, Cartagena, Murcia, Spain. FAU - Hernandez Lopez, Antonio AU - Hernandez Lopez A AD - Endocrinology and Nutrition Department, Reina Sofia University Clinical Hospital, Intendente Jorge Palacios, Murcia, Spain. FAU - Ceron Moreno, Ana Maria AU - Ceron Moreno AM AD - Genomics Laboratory, Clinical Analysis Department, Virgen de la Arrixaca University Clinical Hospital, Carretera Madrid-Cartagena, El Palmar, Murcia, Spain. AD - Department of Biochemistry and Molecular Biology B and Immunology, University of Murcia, Murcia, Spain. AD - Clinical Genetics; Hematology and Clinical-Experimental Oncology; Molecular Therapies and Biomarkers of Solid Tumors, Biomedical Research Institute of Murcia "Pascual Parrilla" (IMIB-Arrixaca), Murcia, Spain. FAU - Guirao Blazquez, Cristina AU - Guirao Blazquez C AD - Genomics Laboratory, Clinical Analysis Department, Virgen de la Arrixaca University Clinical Hospital, Carretera Madrid-Cartagena, El Palmar, Murcia, Spain. AD - Department of Biochemistry and Molecular Biology B and Immunology, University of Murcia, Murcia, Spain. AD - Clinical Genetics; Hematology and Clinical-Experimental Oncology; Molecular Therapies and Biomarkers of Solid Tumors, Biomedical Research Institute of Murcia "Pascual Parrilla" (IMIB-Arrixaca), Murcia, Spain. FAU - Sanchez Cuenca, Juan Jose AU - Sanchez Cuenca JJ AD - Genomics Laboratory, Clinical Analysis Department, Virgen de la Arrixaca University Clinical Hospital, Carretera Madrid-Cartagena, El Palmar, Murcia, Spain. AD - Department of Biochemistry and Molecular Biology B and Immunology, University of Murcia, Murcia, Spain. AD - Clinical Genetics; Hematology and Clinical-Experimental Oncology; Molecular Therapies and Biomarkers of Solid Tumors, Biomedical Research Institute of Murcia "Pascual Parrilla" (IMIB-Arrixaca), Murcia, Spain. FAU - Pascual Gilabert, Patricia AU - Pascual Gilabert P AD - Genomics Laboratory, Clinical Analysis Department, Virgen de la Arrixaca University Clinical Hospital, Carretera Madrid-Cartagena, El Palmar, Murcia, Spain. AD - Department of Biochemistry and Molecular Biology B and Immunology, University of Murcia, Murcia, Spain. AD - Clinical Genetics; Hematology and Clinical-Experimental Oncology; Molecular Therapies and Biomarkers of Solid Tumors, Biomedical Research Institute of Murcia "Pascual Parrilla" (IMIB-Arrixaca), Murcia, Spain. FAU - Anton Martinez, David AU - Anton Martinez D AD - Genomics Laboratory, Clinical Analysis Department, Virgen de la Arrixaca University Clinical Hospital, Carretera Madrid-Cartagena, El Palmar, Murcia, Spain. AD - Department of Biochemistry and Molecular Biology B and Immunology, University of Murcia, Murcia, Spain. AD - Clinical Genetics; Hematology and Clinical-Experimental Oncology; Molecular Therapies and Biomarkers of Solid Tumors, Biomedical Research Institute of Murcia "Pascual Parrilla" (IMIB-Arrixaca), Murcia, Spain. FAU - Noguera Velasco, Jose Antonio AU - Noguera Velasco JA AD - Genomics Laboratory, Clinical Analysis Department, Virgen de la Arrixaca University Clinical Hospital, Carretera Madrid-Cartagena, El Palmar, Murcia, Spain. AD - Department of Biochemistry and Molecular Biology B and Immunology, University of Murcia, Murcia, Spain. AD - Clinical Genetics; Hematology and Clinical-Experimental Oncology; Molecular Therapies and Biomarkers of Solid Tumors, Biomedical Research Institute of Murcia "Pascual Parrilla" (IMIB-Arrixaca), Murcia, Spain. FAU - Ruiz Espejo, Francisco AU - Ruiz Espejo F AD - Genomics Laboratory, Clinical Analysis Department, Virgen de la Arrixaca University Clinical Hospital, Carretera Madrid-Cartagena, El Palmar, Murcia, Spain. AD - Department of Biochemistry and Molecular Biology B and Immunology, University of Murcia, Murcia, Spain. AD - Clinical Genetics; Hematology and Clinical-Experimental Oncology; Molecular Therapies and Biomarkers of Solid Tumors, Biomedical Research Institute of Murcia "Pascual Parrilla" (IMIB-Arrixaca), Murcia, Spain. LA - eng PT - Journal Article DEP - 20260225 PL - England TA - J Endocrinol JT - The Journal of endocrinology JID - 0375363 RN - 0 (Hepatocyte Nuclear Factor 1-alpha) RN - 0 (HNF1A protein, human) RN - 0 (Germinal Center Kinases) RN - 0 (MAP4K2 protein, human) RN - Mason-Type Diabetes SB - IM MH - Humans MH - *Diabetes Mellitus, Type 2/genetics/diagnosis MH - Female MH - *High-Throughput Nucleotide Sequencing/methods MH - Male MH - Adult MH - Hepatocyte Nuclear Factor 1-alpha/genetics MH - Adolescent MH - Genetic Association Studies MH - Young Adult MH - Middle Aged MH - Child MH - Germinal Center Kinases/genetics MH - Mutation OTO - NOTNLM OT - MODY OT - VUS OT - monogenic diabetes OT - next-generation sequencing OT - variants of uncertain significance EDAT- 2026/02/11 13:07 MHDA- 2026/02/25 13:37 CRDT- 2026/02/11 09:43 PHST- 2025/09/15 00:00 [received] PHST- 2026/02/10 00:00 [accepted] PHST- 2026/02/25 13:37 [medline] PHST- 2026/02/11 13:07 [pubmed] PHST- 2026/02/11 09:43 [entrez] AID - JOE-25-0344 [pii] AID - 10.1530/JOE-25-0344 [doi] PST - epublish SO - J Endocrinol. 2026 Feb 25;268(2):e250344. doi: 10.1530/JOE-25-0344. Print 2026 Feb 1. PMID- 41670016 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260925 IS - 1399-3038 (Electronic) IS - 0905-6157 (Print) IS - 0905-6157 (Linking) VI - 37 IP - 2 DP - 2026 Feb TI - Wheat allergy, a new and emerging threat of food allergy for children. PG - e70288 LID - 10.1111/pai.70288 [doi] LID - e70288 AB - Compared to cow's milk, eggs and peanut, knowledge on wheat allergy is limited. During the past 2 decades, IgE-mediated wheat allergy in children has been frequently observed all over the World, especially in Asia. Wheat allergy usually presents in infants between 6 and 12 months of age. Common clinical manifestations are skin rashes (maculopapular rash, urticaria and angioedema). Atopic dermatitis is a less common presenting manifestation in wheat allergy compared to those with egg and cow's milk allergy. Anaphylaxis occurs in up to 50% of wheat allergy in children. Wheat-dependent, exercise-induced anaphylaxis is more common among older children, teenagers and adults. Skin prick testing with water-soluble extract of wheat gave low diagnostic sensitivity. This is because major wheat allergens are alcohol-soluble proteins. Specific IgE to components of wheat such as omega-5 gliadin could increase diagnostic accuracy. The use of these component-resolved wheat allergens both in singleplex and multiplex tests is available but the accuracy of these tests remains to be verified. Wheat avoidance is difficult to carry out since wheat is used for cooking in a wide variety of daily diets. Oral immunotherapy to wheat has been extensively investigated over the past 15 years among children with varying degrees of wheat sensitivities. Most of these children achieved some degree of desensitization to wheat but only a few attained sustained unresponsiveness. To date, it is unclear how long wheat oral immunotherapy should be maintained. Recently, an outbreak in Japan on allergy to soap containing hydrolyzed-wheat suggested that the route of sensitization of wheat was through skin. Discontinuation of marketing of this soap led to cessation of the epidemic. Such knowledge warrants further investigation in children so that a prevention measure for wheat allergy among high-risk infants can be designed. CI - (c) 2026 The Author(s). Pediatric Allergy and Immunology published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. FAU - Vichyanond, Pakit AU - Vichyanond P AUID- ORCID: 0000-0001-5103-2916 AD - Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. FAU - Nagakura, Ken-Ichi AU - Nagakura KI AD - Department of Pediatrics, National Hospital Organization Sagamihara National Hospital, Sagamihara, Kanagawa, Japan. FAU - Pacharn, Punchama AU - Pacharn P AUID- ORCID: 0000-0002-2507-2057 AD - Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. FAU - Wong, Gary AU - Wong G AUID- ORCID: 0000-0001-5939-812X AD - Department of Paediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China. FAU - Sampson, Hugh A AU - Sampson HA AUID- ORCID: 0000-0003-1613-8875 AD - Division of Allergy and Immunology, Department of Pediatrics, Jaffe Food Allergy Institute, Icahn School of Medicine at Mount Sinai, New York, New York, USA. LA - eng PT - Journal Article PT - Review PL - England TA - Pediatr Allergy Immunol JT - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JID - 9106718 RN - 37341-29-0 (Immunoglobulin E) RN - 0 (Allergens) SB - IM MH - Humans MH - *Wheat Hypersensitivity/therapy/diagnosis/epidemiology/immunology MH - Immunoglobulin E/blood MH - Child MH - Allergens/immunology MH - *Desensitization, Immunologic/methods MH - Anaphylaxis/immunology/epidemiology MH - Triticum/immunology MH - Skin Tests MH - Infant PMC - PMC12892388 OTO - NOTNLM OT - anaphylaxis OT - oral food challenge OT - oral immunotherapy OT - wheat allergy OT - omega-5 gliadin COIS- HAS reports grants from Immune Tolerance Network; NIAID/NIH, and the Food Allergy Research & Education (FARE), and personal fees from N-Fold LLC and DBV Technologies, Alpina Biotech AG, RAPT Therapeutics, and Siolta Therapeutics. Other authors report no conflict of interest. EDAT- 2026/02/11 13:08 MHDA- 2026/02/11 13:09 PMCR- 2026/02/11 CRDT- 2026/02/11 06:33 PHST- 2026/01/01 00:00 [revised] PHST- 2025/06/27 00:00 [received] PHST- 2026/01/14 00:00 [accepted] PHST- 2026/02/11 13:09 [medline] PHST- 2026/02/11 13:08 [pubmed] PHST- 2026/02/11 06:33 [entrez] PHST- 2026/02/11 00:00 [pmc-release] AID - PAI70288 [pii] AID - 10.1111/pai.70288 [doi] PST - ppublish SO - Pediatr Allergy Immunol. 2026 Feb;37(2):e70288. doi: 10.1111/pai.70288. PMID- 41669417 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260211 LR - 20260213 IS - 2223-4292 (Print) IS - 2223-4306 (Electronic) IS - 2223-4306 (Linking) VI - 16 IP - 2 DP - 2026 Feb 1 TI - Magnetic resonance imaging-based adenohypophyseal volume for diagnosing hypothalamic-pituitary-gonadal axis activation in pre- and at-puberty children. PG - 151 LID - 10.21037/qims-2025-1677 [doi] LID - 151 AB - BACKGROUND: Central precocious puberty (CPP) results from premature activation of the hypothalamic-pituitary-gonadal (HPG) axis. Although the gonadotropin-releasing hormone (GnRH) stimulation test remains the diagnostic standard for evaluating HPG axis activation, its invasive nature limits clinical utility. Magnetic resonance imaging (MRI)-derived pituitary measurements offer a promising alternative, yet previous studies on two-dimensional measurements have reported limited accuracy. This study aimed to assess the value of adenohypophysis volume (aPV) and height (aPH) precisely measured with the three-dimensional (3D) CUBE T1 sequence (GE HealthCare) in diagnosing HPG axis activation. METHODS: A cohort of 593 children (196 boys and 397 girls; mean age 8.22+/-2.28 years) who underwent pituitary MRI and GnRH stimulation testing was included. Partial correlation analysis, controlling for sex, age, height, weight, and body mass index (BMI), examined the associations of aPV and aPH with peak luteinizing hormone (LH) and the LH to follicle-stimulating hormone (FSH) ratio (LH/FSH). Multiple linear regression models were constructed, and their diagnostic performance was evaluated via receiver operating characteristic (ROC) analysis. RESULTS: aPV showed moderate significant correlations with peak LH (r=0.543; P<0.001) and LH/FSH ratio (r=0.480; P<0.001), which remained significant after controlling for confounders (LH: r=0.283, P<0.001; LH/FSH: r=0.207, P<0.001); meanwhile, the aPH correlations were weaker. Multiple linear regression identified age and aPV as significant predictors for LH peak (aPV: B=0.030; P<0.001), while age, weight, and aPV were significant predictors for LH/FSH (aPV: B=0.002; P<0.001). The regression model for predicting LH/FSH >0.6 yielded an area under the curve (AUC) of 0.841 [95% confidence interval (CI): 0.808-0.871], with a sensitivity of 74.5% and a specificity of 84.9% at the optimal threshold. CONCLUSIONS: aPV may have significant potential to be a noninvasive diagnostic biomarker for assessing HPG axis activation in children with CPP. The developed regression models, incorporating aPV, age, and weight, provide promising diagnostic performance and may potentially reduce the reliance on invasive GnRH stimulation tests. CI - (c) AME Publishing Company. FAU - Gao, Sikang AU - Gao S AUID- ORCID: 0000-0002-4570-5026 AD - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Zhao, Yunyun AU - Zhao Y AUID- ORCID: 0000-0003-2891-9644 AD - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Liu, Weiyin Vivian AU - Liu WV AUID- ORCID: 0000-0002-7917-7612 AD - Bayer Healthcare, Wuhan, China. FAU - Liu, Dong AU - Liu D AUID- ORCID: 0000-0003-0451-5979 AD - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Cai, Jianjian AU - Cai J AUID- ORCID: 0000-0001-6279-5935 AD - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Cai, Longbiao AU - Cai L AUID- ORCID: 0009-0008-8564-2593 AD - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Fang, Jicheng AU - Fang J AUID- ORCID: 0009-0008-5325-377X AD - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Kong, Xianrong AU - Kong X AD - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Tian, Tian AU - Tian T AUID- ORCID: 0000-0002-0224-2957 AD - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Ding, Guojun AU - Ding G AUID- ORCID: 0000-0002-7485-9171 AD - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Wang, Qiuxia AU - Wang Q AD - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. FAU - Liu, Qin AU - Liu Q AUID- ORCID: 0000-0003-0976-0092 AD - Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. LA - eng PT - Journal Article DEP - 20260114 PL - China TA - Quant Imaging Med Surg JT - Quantitative imaging in medicine and surgery JID - 101577942 PMC - PMC12883593 OTO - NOTNLM OT - Adenohypophysis volume (aPV) OT - adenohypophysis height (aPH) OT - central precocious puberty (CPP) OT - hypothalamic-pituitary-gonadal axis (HPG axis) COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://qims.amegroups.com/article/view/10.21037/qims-2025-1677/coif). All authors report that this study was supported by Hubei Provincial Natural Science Foundation of China (grant No. 2023AFB862). W.V.L. reports that she is an employee of Bayer Healthcare. The authors have no other conflicts of interest to declare. EDAT- 2026/02/11 06:30 MHDA- 2026/02/11 06:31 PMCR- 2026/02/01 CRDT- 2026/02/11 04:41 PHST- 2025/08/02 00:00 [received] PHST- 2025/11/28 00:00 [accepted] PHST- 2026/02/11 06:31 [medline] PHST- 2026/02/11 06:30 [pubmed] PHST- 2026/02/11 04:41 [entrez] PHST- 2026/02/01 00:00 [pmc-release] AID - qims-16-02-151 [pii] AID - 10.21037/qims-2025-1677 [doi] PST - ppublish SO - Quant Imaging Med Surg. 2026 Feb 1;16(2):151. doi: 10.21037/qims-2025-1677. Epub 2026 Jan 14. PMID- 41669414 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260211 LR - 20260213 IS - 2223-4292 (Print) IS - 2223-4306 (Electronic) IS - 2223-4306 (Linking) VI - 16 IP - 2 DP - 2026 Feb 1 TI - Vectra H2((R)) stereophotogrammetry system evaluation for 3D facial analysis in children. PG - 124 LID - 10.21037/qims-2025-243 [doi] LID - 124 AB - BACKGROUND: Facial anthropometric analysis is a valuable tool for assessing growth and development in children. It allows for continuous patient monitoring, facilitates the identification of morphological variations and asymmetries, supports diagnostic processes, contributes to the planning and predictability of therapeutic interventions, and aids in evaluating treatment outcomes. This study aimed to evaluate Vectra H2((R)) stereophotogrammetry system for facial anthropometry analysis in children. METHODS: Thirty participants were selected, ranging from 5 to 12 years old. Prior to the acquisition of facial images, nineteen anatomical landmarks were marked with a black eyeliner pen on the participants' faces, so that 14 linear measurements could be quantified. The three-dimensional (3D) image of the facial surface was captured using the stereophotogrammetry equipment. First, linear measurements were quantified directly on the participant's face using a digital caliper. In the second phase of the anthropometric analysis, the same linear measurements were taken on the 3D image using stereophotogrammetry system software. Intraclass correlation coefficient (ICC) test was applied to evaluate intra- and inter-examiner errors. For data analysis, Pearson's and Spearman's correlation coefficient tests were applied. The mean absolute difference (MAD) was used to describe the differences. Data were presented as mean/standard deviation and median/interquartile deviation. RESULTS: All 14 facial measurements showed statistically significant difference (P<0.05). The measurements Tr-G, G-Pn, G-Sn, Ene-Che, and End-Chd demonstrated very strong correlation (r values between 0.9485 and 0.9026), while Ald-Ale, Exe-Che, Sn-Ls, Sn-Pg, Ls-Li, Exd-Chd, and Chd-Che measurements exhibited strong correlation (r values between 0.8821 and 0.7094). Acd-Ace and Cphe-Cphd measurements showed moderate correlation (r=0.5790 and r=0.6982). The measurements Sn-Ls and Ene-Che presented a lower MAD value (0.53), and the measurements Ald-Ale showed the highest value (5.38). CONCLUSIONS: Vectra H2((R)) facial stereophotogrammetry system proved to be a validated and reliable method for facial anthropometry analysis in children. CI - (c) AME Publishing Company. FAU - Mello Peixoto, Yana Cosendey Toledo AU - Mello Peixoto YCT AUID- ORCID: 0000-0002-0527-2158 AD - Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of Sao Paulo, Bauru, Brazil. FAU - Ambrosio, Eloa Cristina Passucci AU - Ambrosio ECP AUID- ORCID: 0000-0003-2322-3832 AD - Hospital for Rehabilitation of Craniofacial Anomalies, University of Sao Paulo, Bauru, Brazil. FAU - Jorge, Paula Karine AU - Jorge PK AUID- ORCID: 0000-0002-9221-8052 AD - Hospital for Rehabilitation of Craniofacial Anomalies, University of Sao Paulo, Bauru, Brazil. FAU - Soares, Simone AU - Soares S AUID- ORCID: 0000-0003-0811-7302 AD - Hospital for Rehabilitation of Craniofacial Anomalies, University of Sao Paulo, Bauru, Brazil. AD - Department of Prosthesis, Bauru School of Dentistry, University of Sao Paulo, Bauru, Brazil. FAU - Carrara, Cleide Felicio Carvalho AU - Carrara CFC AUID- ORCID: 0000-0002-3219-5936 AD - Hospital for Rehabilitation of Craniofacial Anomalies, University of Sao Paulo, Bauru, Brazil. FAU - Sforza, Chiarella AU - Sforza C AUID- ORCID: 0000-0001-6532-6464 AD - Department of Biomedical Sciences for Health, University of Milan, Milan, Italy. FAU - de Menezes, Marcio AU - de Menezes M AUID- ORCID: 0000-0003-2513-9474 AD - Restorative Dentistry, School of Health Science, State University of Amazonas, Manaus, Brazil. FAU - Machado, Maria Aparecida Andrade Moreira AU - Machado MAAM AUID- ORCID: 0000-0003-3778-7444 AD - Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of Sao Paulo, Bauru, Brazil. FAU - Oliveira, Thais Marchini AU - Oliveira TM AUID- ORCID: 0000-0003-3460-3144 AD - Department of Pediatric Dentistry, Orthodontics and Public Health, Bauru School of Dentistry, University of Sao Paulo, Bauru, Brazil. AD - Hospital for Rehabilitation of Craniofacial Anomalies, University of Sao Paulo, Bauru, Brazil. LA - eng PT - Journal Article DEP - 20260123 PL - China TA - Quant Imaging Med Surg JT - Quantitative imaging in medicine and surgery JID - 101577942 PMC - PMC12883492 OTO - NOTNLM OT - Imaging OT - child OT - three-dimensional (3D) OT - validation study COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://qims.amegroups.com/article/view/10.21037/qims-2025-243/coif). The authors have no conflicts of interest to declare. EDAT- 2026/02/11 06:30 MHDA- 2026/02/11 06:31 PMCR- 2026/02/01 CRDT- 2026/02/11 04:41 PHST- 2025/02/02 00:00 [received] PHST- 2025/11/05 00:00 [accepted] PHST- 2026/02/11 06:31 [medline] PHST- 2026/02/11 06:30 [pubmed] PHST- 2026/02/11 04:41 [entrez] PHST- 2026/02/01 00:00 [pmc-release] AID - qims-16-02-124 [pii] AID - 10.21037/qims-2025-243 [doi] PST - ppublish SO - Quant Imaging Med Surg. 2026 Feb 1;16(2):124. doi: 10.21037/qims-2025-243. Epub 2026 Jan 23. PMID- 41668866 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260723 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Analysis of evolution of the policy framework and governance mechanisms and their influence on the institutionalisation process of integrated community case management in Burkina Faso between 2010 and 2024: a scoping review. PG - 1672118 LID - 10.3389/fpubh.2025.1672118 [doi] LID - 1672118 AB - CONTEXT: Integrated Community Case Management (iCCM) has been implemented in Burkina Faso for several years. In view of the insufficient reduction in infant mortality due to multiple factors, strengthening its institutionalisation was recommended in 2019 after Addis Abeba conference. We conducted this study to understand how changes in the policy framework, governance of the system, and power relations between stakeholders have shaped the institutionalisation of iCCM from 2010 to 2024 in Burkina Faso. METHODS: A documentary analysis using the READ approach (Review, Extract, Analyse, Distil) was used to select the documents. After identifying the relevant documents relating to the institutionalisation of iCCM in Burkina Faso (2010-2024) through double validation by two researchers, we used a grid to extract data, which was analysed to identify interactions between three key areas (policy framework development, governance and financing, exercise of power between actors and community involvement) with a view to institutionalisation in Burkina Faso. RESULTS: Starting with a weak political framework in 2010, the pressures of political transitions (2015 and 2022), the ambitions of partners (combating diseases such as HIV/AIDS and malnutrition and achieving development goals), combined with pressures from the social, health and security crisis and research findings, ultimately strengthened political commitment to iCCM. The dominance of partners' power linked to funding facilitated its integration into national health priorities, but limited its transformation into public health policy and its integration into the healthcare chain. Insufficient political commitment to iCCM and the absence of a rigorous regulatory framework for its funding limited the mobilisation of internal financial resources. These challenges were exacerbated by fragmented governance with low community involvement, which impacted implementation and limited ownership and local resolution of certain difficulties. CONCLUSION: The institutionalisation of iCCM in Burkina Faso has been partial. It has been hampered by partial commitment, a lack of a robust regulatory framework for its financing, fragmented governance and vertical management. CI - Copyright (c) 2026 Ouedraogo, Kabore, Ouedraogo, Coulibaly, Soura and Drabo. FAU - Ouedraogo, Hamed Sidwaya AU - Ouedraogo HS AD - Directorate General of Public Health, Ministry of Health, Ouagadougou, Burkina Faso. AD - Health Training and Research Unit/Health Sciences (UFR/SDS), Public Health Laboratory, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso. FAU - Kabore, Ahmed AU - Kabore A AD - Health Training and Research Unit/Health Sciences (UFR/SDS), Public Health Laboratory, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso. AD - Institute of Sports Sciences and Human Development, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso. FAU - Ouedraogo, Daouda AU - Ouedraogo D AD - Directorate General of Public Health, Ministry of Health, Ouagadougou, Burkina Faso. FAU - Coulibaly, Betamou AU - Coulibaly B AD - Directorate General of Public Health, Ministry of Health, Ouagadougou, Burkina Faso. FAU - Soura, Abdramane Bassiahi AU - Soura AB AD - Higher Institute of Population Sciences, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso. FAU - Drabo, Maxime Koine AU - Drabo MK AD - Health Training and Research Unit/Health Sciences (UFR/SDS), Public Health Laboratory, Joseph Ki-Zerbo University, Ouagadougou, Burkina Faso. AD - Institute for Health Sciences Research (IRSS)/CNRST, Ouagadougou, Burkina Faso. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260126 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Burkina Faso MH - *Case Management/organization & administration MH - *Community Health Services/organization & administration MH - *Delivery of Health Care, Integrated/organization & administration MH - *Health Policy MH - *Institutionalization MH - *Policy Making PMC - PMC12883763 OTO - NOTNLM OT - Burkina Faso OT - childhood diseases OT - community dynamics OT - institutionalisation OT - integrated community care OT - policy ownership OT - stakeholders COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/11 06:31 MHDA- 2026/02/11 06:32 PMCR- 2026/01/26 CRDT- 2026/02/11 04:35 PHST- 2025/07/23 00:00 [received] PHST- 2025/11/30 00:00 [revised] PHST- 2025/12/11 00:00 [accepted] PHST- 2026/02/11 06:32 [medline] PHST- 2026/02/11 06:31 [pubmed] PHST- 2026/02/11 04:35 [entrez] PHST- 2026/01/26 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1672118 [doi] PST - epublish SO - Front Public Health. 2026 Jan 26;13:1672118. doi: 10.3389/fpubh.2025.1672118. eCollection 2025. PMID- 41668062 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1757-2215 (Electronic) IS - 1757-2215 (Linking) VI - 19 IP - 1 DP - 2026 Feb 10 TI - Integrative metabolomics and proteomics reveal early cardiovascular risk signatures in PCOS female offspring. PG - 72 LID - 10.1186/s13048-026-02019-8 [doi] LID - 72 AB - BACKGROUND: Polycystic ovary syndrome (PCOS) is associated with metabolism abnormalities and increased cardiovascular disease (CVD) risk. This study aimed to further investigate cardiovascular metabolism alterations specifically in the female offspring of PCOS patients using metabolomics and proteomics, and to identify potential early CVD-related biomarkers in this population. METHODS: A total of 40 female offspring of PCOS patients and 40 female offspring of non-PCOS individuals (4-6 years old) were enrolled in this study. Cardiovascular risk features including height, weight, body mass index (BMI), blood pressure, glycemic and lipid parameters were assessed. Untargeted metabolomics and the Olink proteomics were applied to identify alterations in metabolites and CVD-related proteins. A further in-depth analysis of metabolomics and proteomics was conducted. RESULTS: Lipid indicators, including Total Cholesterol（TC）, Low-Density Lipoprotein Cholesterol（LDL-C）, and high-density lipoprotein cholesterol (HDL-C), as well as gamma-glutamyl transferase (GGT), a marker of liver function were significantly elevated in the female offspring of PCOS patients compared to the female offspring of non-PCOS women. Metabolomic profiling revealed significant alterations in lipid metabolites, particularly in glycerophospholipids and fatty acids, in the female offspring of PCOS patients. Additionally, elevated levels of CVD-related proteins, including proprotein convertase subtilisin/kexin type (PCSK9), tissue factor pathway inhibitor (TFPI), secretoglobin family 3A member 2 (SCGB3A2), junctional adhesion molecule A (JAM-A), interleukin-1 receptor-like 1 (ST2) and epidermal growth factor receptor (EGFR) were observed, with significant correlations between these proteins and the altered lipid metabolites. We conducted mediation analysis and identified several metabolites and proteins that mediate cardiovascular risk. A a combined metabolite and protein panel consisting of phospholipids (PIs), lysophosphatidylcholines (LysoPCs), and CVD-related proteins demonstrated an area under the curve (AUC) of 0.93 based on receiver operating characteristic (ROC) curve analysis, effectively differentiating female offspring with hyperlipidemia. CONCLUSIONS: Female offspring of PCOS patients exhibit distinct lipid metabolic and protein profiles that suggest early cardiovascular-related alterations. These findings support the potential value of early metabolic monitoring in this population and highlight the need for longitudinal studies to determine whether these alterations translate to increased cardiovascular risk in adulthood. The identified metabolite and protein biomarkers may serve as tools for early risk assessment, pending prospective validation of their long-term predictive value. FAU - Wu, Xinyue AU - Wu X AD - Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, No.1 Xueshi Road, Hangzhou, Zhejiang, 310006, China. AD - Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. AD - Institute of Medical Genetics and Development, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Deng, Xiangning AU - Deng X AD - Department of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China. FAU - Liu, Shuangying AU - Liu S AD - Department of Gynecology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. FAU - Xie, Aqiong AU - Xie A AD - Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, No.1 Xueshi Road, Hangzhou, Zhejiang, 310006, China. AD - Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. AD - Institute of Medical Genetics and Development, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Yang, Yingzhi AU - Yang Y AD - Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, No.1 Xueshi Road, Hangzhou, Zhejiang, 310006, China. AD - Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. AD - Institute of Medical Genetics and Development, Zhejiang University, Hangzhou, Zhejiang, China. FAU - Wang, Haining AU - Wang H AD - Department of Endocrinology and Metabolism, Peking University Third Hospital, Beijing, China. FAU - Zhu, Yimin AU - Zhu Y AD - Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, No.1 Xueshi Road, Hangzhou, Zhejiang, 310006, China. zhuyim@zju.edu.cn. AD - Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. zhuyim@zju.edu.cn. AD - Institute of Medical Genetics and Development, Zhejiang University, Hangzhou, Zhejiang, China. zhuyim@zju.edu.cn. FAU - Tang, Minyue AU - Tang M AD - Department of Reproductive Endocrinology, School of Medicine, Women's Hospital, Zhejiang University, No.1 Xueshi Road, Hangzhou, Zhejiang, 310006, China. tangmy@zju.edu.cn. AD - Key Laboratory of Reproductive Genetics (Ministry of Education), Women's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. tangmy@zju.edu.cn. AD - Institute of Medical Genetics and Development, Zhejiang University, Hangzhou, Zhejiang, China. tangmy@zju.edu.cn. LA - eng GR - 2023-CCA-NLD-563/Chinese Cardiovascular Association-Natural lipid-lowering drugs fund/ GR - 2025C02116/the Key research and development Program of Zhejiang Province/ PT - Journal Article DEP - 20260210 PL - England TA - J Ovarian Res JT - Journal of ovarian research JID - 101474849 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/complications/metabolism MH - *Proteomics/methods MH - *Metabolomics/methods MH - *Cardiovascular Diseases/metabolism/etiology MH - Biomarkers MH - Child MH - Heart Disease Risk Factors MH - Child, Preschool MH - Risk Factors PMC - PMC12918623 OTO - NOTNLM OT - Cardiovascular risk features OT - Dislipidemia OT - Female Offspring OT - Metabolomics OT - PCOS OT - Proteomics COIS- Declarations. Ethics approval and consent to participate: All sample collection procedures were approved by the Institutional Review Board of Women's Hospital, School of Medicine, Zhejiang University (Approval No. IRB-20220331-R) and written informed consent was obtained from all participants and by a parent or guardian with parental responsibility on behalf of their children. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/11 00:40 MHDA- 2026/06/27 18:38 PMCR- 2026/02/10 CRDT- 2026/02/10 23:51 PHST- 2025/11/02 00:00 [received] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/06/27 18:38 [medline] PHST- 2026/02/11 00:40 [pubmed] PHST- 2026/02/10 23:51 [entrez] PHST- 2026/02/10 00:00 [pmc-release] AID - 10.1186/s13048-026-02019-8 [pii] AID - 2019 [pii] AID - 10.1186/s13048-026-02019-8 [doi] PST - epublish SO - J Ovarian Res. 2026 Feb 10;19(1):72. doi: 10.1186/s13048-026-02019-8. PMID- 41668015 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Feb 11 TI - Associations between 24-h movement behaviors and optimal mental health of Chinese university students: a compositional data analysis. LID - 10.1186/s12889-026-26534-x [doi] LID - 872 AB - OBJECTIVE: This cross-sectional study aimed to examine the associations between the 24-h movement behaviors and mental health among university students in China, and to determine the optimal behavioral balance based on the top 5% of model-predicted mental health outcomes using compositional data analysis. METHODS: A total of 6,084 university students aged 17-24 years in Southwest China self-reported their daily durations of moderate-to-vigorous-intensity physical activity (MVPA), light-intensity physical activity (LPA), sedentary behavior (SED), and sleep (SLP). They were stratified by gender and then randomly and equally assigned to the "recommendation" group and the "validation" group. Using compositional data analysis, time-use compositions (MVPA, LPA, SED, SLP) were transformed into isometric log-ratios (with quadratic terms as needed) and subsequently used in regression models to predict the three mental health outcomes. All possible combinations of motion components were examined to determine the combination with the highest correlation (top 5%) for each outcome. RESULTS: Through research and analysis of the recommendation groups, the optimal combination of average (range) time usage is determined as follows: for males, MVPA 92 (60-110) min/day, LPA 361 (310-400) min/day, SED 372 (350-480) min/day, SLP 614 (530-680) min/day; for females, MVPA 58 (40-90) min/day, LPA 290 (180-390) min/day, SED 445 min (400-560), SLP 665 (580-740) min/day. The recommended durations served as benchmarks for the validation group. Participants who met the optimal 24-h movement behavior time showed significantly lower depression (males: beta = -1.290, P < 0.05; females: beta = -1.040, P < 0.05), anxiety (males: beta = -1.350, P < 0.05; females: beta = -1.760, P < 0.001), and stress (males: beta = -1.280, P < 0.05; females: beta = -1.340, P < 0.05) compared to those who did not meet the criteria. Only 14.4% of males and 8.9% of females in the validation sample simultaneously met the recommended times for all four movement behaviors. CONCLUSION: The optimal 24-h movement behavior time differs between men and women. Males tend to require a longer optimal MVPA duration than females, while females require a longer optimal SLP duration than males. The findings provide valuable reference for developing 24-h movement guidelines and promoting healthy and balanced lifestyles among university students. FAU - Li, Chenlin AU - Li C AD - School of Physical Education, Shanghai University of Sport, Shanghai, China. FAU - Qiu, Yanping AU - Qiu Y AD - School of Physical Education, Shanghai University of Sport, Shanghai, China. FAU - Zheng, Nan AU - Zheng N AD - School of Physical Education, Shanghai University of Sport, Shanghai, China. FAU - Liu, Yuwei AU - Liu Y AD - School of Physical Education, Shanghai University of Sport, Shanghai, China. FAU - Yang, Xinglong AU - Yang X AD - Wanchun School, Wenjiang District, Chengdu, China. FAU - Wang, Lijuan AU - Wang L AD - School of Physical Education, Shanghai University of Sport, Shanghai, China. wlj711@aliyun.com. LA - eng PT - Journal Article DEP - 20260211 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Male MH - Female MH - *Students/psychology/statistics & numerical data MH - Universities MH - Young Adult MH - China MH - Cross-Sectional Studies MH - Adolescent MH - *Mental Health/statistics & numerical data MH - *Exercise/psychology MH - Sedentary Behavior MH - Sleep PMC - PMC12980977 OTO - NOTNLM OT - 24-h movement behavior OT - Compositional data analysis OT - Mental health OT - Time-use OT - University students COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Tenets of the Declaration of Helsinki. Complete research objectives and survey contents were explained to the participants. All participants provided electronic informed consent and agreed to the required measurement and survey completion procedures. Ethical approval for this study was obtained from the Ethics Committee of China West Normal University (Approval No. 2025LLSC0047). Consent for publication: This manuscript does not contain an individual person's data; therefore, consent for publication is not required. Competing interests: The authors declare no competing interests. EDAT- 2026/02/11 00:39 MHDA- 2026/06/27 06:43 PMCR- 2026/02/11 CRDT- 2026/02/10 23:49 PHST- 2025/11/24 00:00 [received] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/06/27 06:43 [medline] PHST- 2026/02/11 00:39 [pubmed] PHST- 2026/02/10 23:49 [entrez] PHST- 2026/02/11 00:00 [pmc-release] AID - 10.1186/s12889-026-26534-x [pii] AID - 26534 [pii] AID - 10.1186/s12889-026-26534-x [doi] PST - epublish SO - BMC Public Health. 2026 Feb 11;26(1):872. doi: 10.1186/s12889-026-26534-x. PMID- 41668006 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Feb 11 TI - A nomogram for predicting fetal growth restriction in patients with preeclampsia based on complete blood count results at 20-24 weeks of gestation: a retrospective case-control study in China. LID - 10.1186/s12884-026-08783-1 [doi] LID - 296 AB - BACKGROUND: Preeclampsia (PE) complicated by fetal growth restriction (FGR) is associated with high pediatric morbidity and mortality. The current predictive model mainly focus on using ultrasound or serum biomarkers that is relative high testing cost and a lack of technical accessibility in low-income countries. Our study aimed to investigate whether the occurrence of FGR in patients with PE could be predicted using results from low-cost complete blood count (CBC) tests at 20-24 weeks of gestation. METHODS: In this retrospective study, we reviewed all cases of patients with PE who received routine prenatal care and delivered at our hospital from April 2019 to April 2022. Patients diagnosed with PE were paired with healthy pregnant women using 1:1 matching on the basis of similar age, parity, and pregestational body mass index (BMI). Routine peripheral blood cell results between 20 and 24 weeks of gestation were collected and analyzed using logistic regression to identify independent risk factors in the normotensive pregnancy, the PE with FGR and the PE with normal birth weight (NBW) groups. A nomogram was subsequently developed to quantify the risk of FGR in patients with PE. Finally, we assessed the model's predictive performance. RESULTS: A total of 392 patients with PE were included, consisting of 66 patients with FGR, 326 with NBW, and 392 with normotensive pregnancies. The nomogram included three independent risk factors: a lymphocyte count >/= 2.05 x 10(9)/L, a neutrophil-to-lymphocyte ratio (NLR) 60 scores). CONCLUSIONS: Our predictive model, based on routine peripheral blood cell results at 20-24 weeks of gestation, could provide insight into earlier prediction of FGR occurrence in patients with PE, facilitating further fetal monitoring and clinical decision-making. CI - (c) 2026. The Author(s). FAU - Li, Na AU - Li N AD - Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Xueshi Rd NO. 1, Hangzhou, 310006, Zhejiang, People's Republic of China. FAU - Shu, Shu-Juan AU - Shu SJ AD - Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Xueshi Rd NO. 1, Hangzhou, 310006, Zhejiang, People's Republic of China. FAU - Wang, Miao-Miao AU - Wang MM AD - Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Xueshi Rd NO. 1, Hangzhou, 310006, Zhejiang, People's Republic of China. FAU - Xu, Shu-Hang AU - Xu SH AD - Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Xueshi Rd NO. 1, Hangzhou, 310006, Zhejiang, People's Republic of China. FAU - Huang, Xiao-Xiu AU - Huang XX AD - Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Xueshi Rd NO. 1, Hangzhou, 310006, Zhejiang, People's Republic of China. FAU - Li, Bao-Hua AU - Li BH AD - Department of Obstetrics, Women's Hospital, Zhejiang University School of Medicine, Xueshi Rd NO. 1, Hangzhou, 310006, Zhejiang, People's Republic of China. lbh19787@zju.edu.cn. LA - eng GR - LY24H040003/Natural Science Foundation of Zhejiang Province/ GR - ZDFY2021-4X206/4+X Clinical Research Project of Women's Hospital, School of Medicine, Zhejiang University/ PT - Journal Article DEP - 20260211 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Nomograms MH - *Fetal Growth Retardation/diagnosis/blood/etiology MH - Retrospective Studies MH - *Pre-Eclampsia/blood MH - Case-Control Studies MH - Adult MH - China MH - Blood Cell Count MH - Pregnancy Trimester, Second/blood MH - Predictive Value of Tests MH - Gestational Age MH - Risk Factors PMC - PMC12998305 OTO - NOTNLM OT - Blood cell count OT - Fetal growth restriction OT - Nomogram OT - Preeclampsia COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of the Women's Hospital, School of Medicine, Zhejiang University (IRB-20250279-R). All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The requirement for informed consent was waived off by the Ethics Committee of the Women's Hospital, School of Medicine, Zhejiang University. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/11 00:39 MHDA- 2026/03/19 07:11 PMCR- 2026/02/11 CRDT- 2026/02/10 23:49 PHST- 2025/09/08 00:00 [received] PHST- 2026/02/04 00:00 [accepted] PHST- 2026/03/19 07:11 [medline] PHST- 2026/02/11 00:39 [pubmed] PHST- 2026/02/10 23:49 [entrez] PHST- 2026/02/11 00:00 [pmc-release] AID - 10.1186/s12884-026-08783-1 [pii] AID - 8783 [pii] AID - 10.1186/s12884-026-08783-1 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Feb 11;26(1):296. doi: 10.1186/s12884-026-08783-1. PMID- 41667395 OWN - NLM STAT- MEDLINE DCOM- 20260805 LR - 20260810 IS - 1748-3115 (Electronic) IS - 1748-3107 (Linking) VI - 21 IP - 5 DP - 2026 Jul TI - The development of a web-based PJOK digital learning media to increase deaf students' motor skills and literacy. PG - 2229-2243 LID - 10.1080/17483107.2026.2624720 [doi] AB - Objective This research focuses on the development and validation of TOTURU, a web-based digital learning media designed to support Physical Education (PJOK) learning for Deaf students. Methods Guided by a Research and Development (R&D) approach and operationalised through the ADDIE model, this study aims to address the difficulties Deaf learners face in accessing visually clear and accessible instructional content. The prototype was developed to meet Technology Readiness Level 2 (TRL 2), emphasising conceptual design and early-stage validation. The study involved 23 Deaf students from SLB Pembina, South Sulawesi. Development results show that TOTURU incorporates visual-sensory features, instructional videos, and sign-supported explanations tailored to Deaf learners. Validation by material and media experts yielded high feasibility scores, with both categories rated as Very Valid, confirming the accuracy, accessibility, and usability of the platform. User validation using a Guttman-scale instrument (20 items across usability, information quality, and display quality) demonstrated strong positive acceptance. Furthermore, pre- and post-use analysis revealed a 58.1% increase in students' learning interest, indicating that the platform effectively enhances motivation, engagement, and comprehension in PJOK learning. Impact Overall, the study provides a validated digital learning prototype that contributes to inclusive education by offering accessible, visually oriented learning media for Deaf students and establishing a foundation for further development at higher TRL stages. FAU - Abdul Gani, Hamsu AU - Abdul Gani H AD - Faculty of Engineering, Universitas Negeri Makassar, Makassar, Indonesia. FAU - Fadlih, Andi Muhammad AU - Fadlih AM AD - Faculty of Sports and Health, Universitas Negeri Makassar, Makassar, Indonesia. FAU - Affandi, Akhmad AU - Affandi A AD - Faculty of Language and Literature, Universitas Negeri Makassar, Makassar, Indonesia. FAU - Ikadarny AU - Ikadarny AD - Faculty of Sports and Health, Universitas Negeri Makassar, Makassar, Indonesia. LA - eng PT - Journal Article DEP - 20260210 PL - England TA - Disabil Rehabil Assist Technol JT - Disability and rehabilitation. Assistive technology JID - 101255937 SB - IM MH - Humans MH - Digital Media MH - *Internet MH - *Motor Skills MH - Male MH - Female MH - *Education of Persons with Hearing Disabilities/methods MH - Students MH - Adolescent MH - Learning MH - *Persons with Hearing Disabilities MH - *Deafness/rehabilitation OAB - Enhancing Motor and Literacy DevelopmentThe TOTURU platform demonstrates that web-based, visually oriented media can significantly improve both motor skills and literacy engagement among deaf students. Its multimodal design-integrating sign language, animations, and interactive content-can be adapted for broader rehabilitation contexts to support fine and gross motor coordination training.Facilitating Inclusive Physical EducationBy providing accessible instructional materials, TOTURU bridges the communication gap between teachers and deaf learners, enabling equitable participation in physical education activities. This model can guide other rehabilitation programs seeking to integrate assistive digital technologies into inclusive sport and exercise education.Promoting Visual-Based Rehabilitation ApproachesThe study reinforces the effectiveness of visual and interactive learning media in rehabilitation pedagogy, especially for learners with sensory impairments. The platform's bilingual interface (Bahasa Indonesia and SIBI) provides a framework for culturally adapted rehabilitation interventions in multilingual contexts.Supporting Teacher and Therapist Capacity BuildingTOTURU can serve as a training tool for teachers and rehabilitation specialists to better understand deaf learners' communication needs, offering templates for lesson design, instructional visuals, and motor-skill demonstrations that comply with inclusive education standards.Expanding Technological Readiness in RehabilitationAs a TRL-2 innovation, TOTURU's current framework can evolve towards integration with Augmented Reality (AR) or Virtual Reality (VR) environments to enhance kinaesthetic learning and therapeutic engagement, opening pathways for technology-supported rehabilitation research.A web-based digital learning platform prototype tailored to the unique needs of deaf learner.Designing inclusive digital learning media that takes sensory considerations into account and the communication needs for individuals with hearing loss.The platform developed produces data regarding the increasing interest in motor skills and deaf literacy towards PJOK. OABL- eng OTO - NOTNLM OT - Digital learning OT - deaf students OT - hearing impairments OT - inclusive education OT - media development EDAT- 2026/02/11 00:39 MHDA- 2026/08/05 06:42 CRDT- 2026/02/10 22:33 PHST- 2026/08/05 06:42 [medline] PHST- 2026/02/11 00:39 [pubmed] PHST- 2026/02/10 22:33 [entrez] AID - 10.1080/17483107.2026.2624720 [doi] PST - ppublish SO - Disabil Rehabil Assist Technol. 2026 Jul;21(5):2229-2243. doi: 10.1080/17483107.2026.2624720. Epub 2026 Feb 10. PMID- 41667175 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 2 DP - 2026 Feb 10 TI - Feasibility of a mobile health intervention to motivate adolescent fitness and high-intensity exercise adherence (Motivating Adolescent Fitness (MOTAFIT)): protocol for a randomised controlled trial. PG - e112546 LID - 10.1136/bmjopen-2025-112546 [doi] LID - e112546 AB - INTRODUCTION: Most adolescents fail to achieve recommended levels of vigorous-intensity physical activity, despite the established benefits for cardiorespiratory fitness and vascular health. Supervised interventions can be effective, but are resource-intensive and lack scalability. Mobile health (mHealth) technologies may provide a cost-effective and accessible approach to support structured, individualised training for adolescents. The Motivating Adolescent Fitness (MOTAFIT) trial will assess the feasibility and acceptability of an mHealth-supported exercise intervention for adolescents to inform the design of a definitive randomised controlled trial (RCT). METHODS AND ANALYSIS: MOTAFIT is a three-arm feasibility RCT targeting 120 adolescents aged 13-16 years from the Okanagan Valley, British Columbia. Participants will be randomised (1:1:1) to: (1) MOTAFIT, (2) active control or (3) control group. The 12-week intervention targets >/=40 min/week of vigorous-intensity exercise (>/=80% HRmax), co-designed with an exercise specialist and supported by mHealth technology. Primary outcomes for feasibility, including recruitment, retention, adherence, fidelity and acceptability, will be assessed as part of a process evaluation. Secondary measures (cardiorespiratory fitness, vascular health and blood pressure) will provide preliminary estimates to guide future sample size calculations. ETHICS AND DISSEMINATION: The study has received approval from the University of British Columbia Clinical Research Ethics Board (H22-03183) and the University of Victoria Human Research Ethics Board. Parental consent and adolescent assent will be obtained prior to participation. Findings will be disseminated via peer-reviewed publications, conferences and community engagement. TRIAL REGISTRATION NUMBER: NCT06409793. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Koep, Jodie L AU - Koep JL AUID- ORCID: 0000-0003-4137-6840 AD - School of Health and Exercise Sciences, The University of British Columbia Okanagan, Kelowna, British Columbia, Canada jodie.koep@ubc.ca. FAU - Sansum, Kate M AU - Sansum KM AD - School of Health and Exercise Sciences, The University of British Columbia Okanagan, Kelowna, British Columbia, Canada. FAU - Low, Jonathan AU - Low J AUID- ORCID: 0000-0002-1964-6237 AD - School of Health and Exercise Sciences, The University of British Columbia Okanagan, Kelowna, British Columbia, Canada. AD - Faculty of Kinesiology, University of Calgary, Calgary, Alberta, Canada. FAU - Smith, Kurt J AU - Smith KJ AD - Department of Exercise Science, Physical & Health Education, University of Victoria, Victoria, British Columbia, Canada. FAU - Cocks, Matthew AU - Cocks M AUID- ORCID: 0000-0003-1671-8714 AD - Research Institute for Sport and Exercise Sciences, Liverpool John Moores University, Liverpool, UK. FAU - McManus, Alison M AU - McManus AM AD - School of Health and Exercise Sciences, The University of British Columbia Okanagan, Kelowna, British Columbia, Canada. LA - eng SI - ClinicalTrials.gov/NCT06409793 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260210 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - British Columbia MH - *Cardiorespiratory Fitness MH - *Exercise MH - Feasibility Studies MH - *Motivation MH - *Patient Compliance MH - Physical Fitness MH - Randomized Controlled Trials as Topic MH - Telemedicine PMC - PMC12911803 OTO - NOTNLM OT - Adolescents OT - Digital Technology OT - Exercise COIS- Competing interests: None declared. EDAT- 2026/02/11 00:39 MHDA- 2026/02/11 00:40 PMCR- 2026/02/10 CRDT- 2026/02/10 20:43 PHST- 2026/02/11 00:40 [medline] PHST- 2026/02/11 00:39 [pubmed] PHST- 2026/02/10 20:43 [entrez] PHST- 2026/02/10 00:00 [pmc-release] AID - bmjopen-2025-112546 [pii] AID - 10.1136/bmjopen-2025-112546 [doi] PST - epublish SO - BMJ Open. 2026 Feb 10;16(2):e112546. doi: 10.1136/bmjopen-2025-112546. PMID- 41665816 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20261009 IS - 1436-3771 (Electronic) IS - 1432-6981 (Linking) VI - 30 IP - 2 DP - 2026 Feb 10 TI - Influence of vertical skeletal patterns on cancellous bone volume in the mandibular ramus relevant to sagittal split ramus osteotomy in skeletal class III patients: A cone-beam computed tomography analysis. PG - 77 LID - 10.1007/s00784-026-06773-3 [doi] AB - OBJECTIVES: To determine whether the vertical skeletal pattern influences cancellous bone volume and related ratios in sagittal split ramus osteotomy (SSRO)-relevant regions of the mandibular ramus in skeletal Class III patients, and to quantify covariate effects. MATERIALS AND METHODS: This single-center retrospective study included 112 patients (224 rami). Cone-beam computed tomography-based 3D segmentations quantified cancellous volume (ROI.S), cortical volume (ROI.C), total bone (TB), and ratios S:C and S:TB within a standardized ramal ROI. Because each patient contributed bilateral rami, within-patient correlation was accounted for using mixed-effects models (random intercept) for ROI.S, ROI.C, TB, ln-transform for S:C, and generalized estimating equations with an appropriate link were used for the bounded proportion S:TB (0-1). All models adjusted for sex, age, BMI, and side. Omnibus pattern effects were tested, with Bonferroni-adjusted pairwise comparisons reported when applicable. Intra- and inter-observer intraclass correlation coefficients (ICCs) were assessed in a 10-patient subset. RESULTS: Vertical skeletal pattern was not associated with ROI.S (P = 0.17). Omnibus effects were observed for ROI.C (P = 0.04) and TB (P = 0.03), but no pairwise contrast remained significant after Bonferroni adjustment. The ratios showed no pattern effect (ln[S:C], P = 0.69; S:TB, P = 0.64). Males had larger ROI.S, ROI.C, and TB and a higher cancellous proportion. CONCLUSIONS: Vertical skeletal pattern does not materially influence cancellous volume or its ratios within SSRO-relevant ramal ROIs, whereas sex shows consistent volumetric and proportional differences. CLINICAL RELEVANCE: Patient-specific CBCT volumetry provides reproducible quantitative information beyond skeletal pattern classification and may aid SSRO planning by identifying patients with relatively limited cancellous support. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Kaewwongwattana, Parinya AU - Kaewwongwattana P AUID- ORCID: 0009-0008-1987-3481 AD - Faculty of Dentistry, Chiang Mai University, Suthep Rd, Muang Chiang Mai District, Chiang Mai, Thailand. FAU - Sriyaranya, Nutchada AU - Sriyaranya N AUID- ORCID: 0000-0002-8479-368X AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand. FAU - Suttitumrongsawat, Chinnakrit AU - Suttitumrongsawat C AD - Dental Department, Kabinburi Hospital, Prajeenburi, Thailand. FAU - Aschaitrakool, Yuthakran AU - Aschaitrakool Y AUID- ORCID: 0000-0002-0305-6638 AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand. FAU - Chinkrua, Chonatee AU - Chinkrua C AUID- ORCID: 0009-0005-9392-7300 AD - Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand. chonatee.ch@cmu.ac.th. LA - eng PT - Journal Article DEP - 20260210 PL - Germany TA - Clin Oral Investig JT - Clinical oral investigations JID - 9707115 SB - IM MH - Humans MH - *Cone-Beam Computed Tomography/methods MH - Male MH - Female MH - Retrospective Studies MH - *Osteotomy, Sagittal Split Ramus/methods MH - *Cancellous Bone/diagnostic imaging/anatomy & histology MH - *Mandible/diagnostic imaging/surgery MH - *Malocclusion, Angle Class III/surgery/diagnostic imaging MH - Adult MH - Adolescent MH - Imaging, Three-Dimensional OTO - NOTNLM OT - Cancellous bone volume OT - Cone-beam computed tomography (CBCT) OT - Sagittal split ramus osteotomy (SSRO) OT - Vertical skeletal pattern OT - Volumetric analysis COIS- Declarations. Ethical approval: Ethical approval for this study was obtained from the Ethics Committee of the Faculty of Dentistry, Chiang Mai University (No. 032/2023). The study was conducted in accordance with the Declaration of Helsinki and relevant ethical guidelines. Competing interests: The authors declare no competing interests. EDAT- 2026/02/10 19:00 MHDA- 2026/02/10 19:01 CRDT- 2026/02/10 12:05 PHST- 2025/09/01 00:00 [received] PHST- 2026/01/29 00:00 [accepted] PHST- 2026/02/10 19:01 [medline] PHST- 2026/02/10 19:00 [pubmed] PHST- 2026/02/10 12:05 [entrez] AID - 10.1007/s00784-026-06773-3 [pii] AID - 10.1007/s00784-026-06773-3 [doi] PST - epublish SO - Clin Oral Investig. 2026 Feb 10;30(2):77. doi: 10.1007/s00784-026-06773-3. PMID- 41665677 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1432-086X (Electronic) IS - 0174-1551 (Linking) VI - 49 IP - 5 DP - 2026 May TI - The Prognostic Nutritional Index (PNI) as a Biomarker for Predicting Survival in Hepatocellular Carcinoma Patients Treated with Transarterial Chemoembolization and Lenvatinib, With or Without Programmed Death-1(PD-1) Inhibitors. PG - 924-936 LID - 10.1007/s00270-025-04334-x [doi] AB - PURPOSE: Current treatment strategies for hepatocellular carcinoma (HCC) using transarterial chemoembolization (TACE) combined with lenvatinib and immunotherapy remain largely empirical due to the lack of reliable biomarkers. This study aimed to evaluate the prognostic significance of the Prognostic Nutritional Index (PNI) in HCC patients treated with TACE plus lenvatinib, with or without programmed death-1 (PD-1) inhibitors. MATERIALS AND METHODS: We conducted a retrospective analysis of 237 patients with HCC who received TACE and lenvatinib-based therapy, with or without PD-1 inhibitors, between March 2021 and September 2023. Patients were randomly allocated into training and validation sets in a 7:3 ratio and stratified into low- and high-PNI groups based on an optimal PNI cut-off value. Overall survival (OS) and progression-free survival (PFS) were compared between the PNI groups using the log-rank test. RESULTS: In both the training and validation sets, patients with higher PNI scores demonstrated significantly better OS and PFS than those with lower PNI scores. Multivariate Cox regression identified PNI score, treatment modality (TACE + lenvatinib +/- PD-1 inhibitor), tumor diameter, alpha-fetoprotein (AFP), and alanine aminotransferase (ALT) as independent prognostic factors for OS. For PFS, independent predictors included PNI score, treatment modality, tumor diameter, Child-Pugh class, and AFP level. Subgroup analyses consistently showed superior OS in the high-PNI group across most strata, including those defined by treatment type, presence of portal vein tumor thrombosis (PVTT) or extrahepatic metastasis (EHM), AFP level ( 400 ng/mL), and Barcelona Clinic Liver Cancer (BCLC) stage C. CONCLUSION: The PNI score is a promising biomarker for predicting survival in HCC patients receiving TACE combined with lenvatinib, with or without PD-1 inhibitors. Low PNI is associated with poor survival outcomes, highlighting its potential utility in risk stratification and treatment planning. CI - (c) 2026. Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE). FAU - Xu, Wenji AU - Xu W AD - College of Medical Imaging, Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China. FAU - Yan, Zhening AU - Yan Z AD - Department of Hepatobiliary Surgery, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China. FAU - Zhao, Yushan AU - Zhao Y AD - Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, 030001, China. FAU - Guo, Peng AU - Guo P AD - Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China. FAU - Wang, Rong AU - Wang R AD - Department of Oncology and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China. FAU - Zhang, Rui AU - Zhang R AD - Department of Hepatobiliary Surgery, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China. FAU - Feng, Duiping AU - Feng D AD - Department of Oncology and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China. FAU - Zhang, Ruiping AU - Zhang R AD - The Radiology Department of Shanxi Provincial People's Hospital, The Fifth Hospital of Shanxi Medical University, Taiyuan, 030001, China. zrp_7142@sxmu.edu.cn. FAU - Chen, Yi AU - Chen Y AUID- ORCID: 0000-0002-0352-0664 AD - Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China. chenyi@sxbqeh.com.cn. AD - Department of Oncology and Vascular Intervention, First Hospital of Shanxi Medical University, Taiyuan, 030001, Shanxi Province, China. chenyi@sxbqeh.com.cn. LA - eng GR - 202303021211201/Natural Science Foundation of Shanxi Province/ GR - 20210302123255/Natural Science Foundation of Shanxi Province/ PT - Journal Article DEP - 20260210 PL - United States TA - Cardiovasc Intervent Radiol JT - Cardiovascular and interventional radiology JID - 8003538 RN - 0 (Phenylurea Compounds) RN - EE083865G2 (lenvatinib) RN - 0 (Quinolines) RN - 0 (Immune Checkpoint Inhibitors) SB - IM MH - Humans MH - *Carcinoma, Hepatocellular/therapy/mortality MH - *Phenylurea Compounds/therapeutic use/administration & dosage MH - *Quinolines/therapeutic use MH - *Liver Neoplasms/therapy/mortality MH - Female MH - Male MH - Retrospective Studies MH - *Chemoembolization, Therapeutic/methods MH - Prognosis MH - Middle Aged MH - *Nutrition Assessment MH - Aged MH - *Immune Checkpoint Inhibitors/therapeutic use OTO - NOTNLM OT - Hepatocellular carcinoma OT - Lenvatinib OT - PD-1 inhibitor OT - Prognostic nutritional index OT - Survival COIS- Declarations. Ethics Approval and Consent to Participate: Institutional Review Board approval was obtained. The Ethics Board of the First Hospital of Shanxi Medical University (approval number: NO.KYYJ-2023-017) has approved for this retrospective study. Written informed consent for the medical treatments (TACE, lenvatinib, and/or PD-1 inhibitors) was obtained from all patients prior to their procedures. This study was performed in accordance with the Declaration of Helsinki and the Ethical Guidelines for Clinical Studies. Consent for Publication: All authors consent for the publication of this manuscript. EDAT- 2026/02/10 13:31 MHDA- 2026/05/08 12:37 CRDT- 2026/02/10 11:15 PHST- 2025/10/07 00:00 [received] PHST- 2025/12/17 00:00 [accepted] PHST- 2026/05/08 12:37 [medline] PHST- 2026/02/10 13:31 [pubmed] PHST- 2026/02/10 11:15 [entrez] AID - 10.1007/s00270-025-04334-x [pii] AID - 10.1007/s00270-025-04334-x [doi] PST - ppublish SO - Cardiovasc Intervent Radiol. 2026 May;49(5):924-936. doi: 10.1007/s00270-025-04334-x. Epub 2026 Feb 10. PMID- 41665507 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1552-3365 (Electronic) IS - 0363-5465 (Linking) VI - 54 IP - 3 DP - 2026 Mar TI - Ankle-GO Score to Identify Elite Basketball Players Who Will Suffer Lateral Ankle Sprain During a Competitive Season: A 1-Year Prospective Cohort Study. PG - 678-685 LID - 10.1177/03635465251410554 [doi] AB - BACKGROUND: Lateral ankle sprain (LAS) is the most common injury in basketball, and identifying at-risk players is of high importance. PURPOSE: To evaluate the ability of the Ankle-GO score to identify elite basketball players who will suffer LAS during a competitive season as well as other potential predictive factors. STUDY DESIGN: Cross-sectional study; Level of evidence, 2. METHODS: A total of 48 elite basketball players (22 male, 26 female; mean +/- SD age, 17.9 +/- 3.7 years) performed the Ankle-GO score on both limbs during a preseason session. This score is a cluster of functional tests and self-reported questionnaires evaluating ankle function. LAS incidence was recorded throughout the competitive season for each ankle of the players. Potential predictive variables (Ankle-GO, body mass index, history of previous LAS, and sex) associated with LAS were compared between injured and uninjured athletes. The areas under the receiver operating characteristic curve (AUCs) and multivariable logistic regression models with odds ratio (OR) and 95% CI were used to identify potential factors of LAS. RESULTS: A total of 17 occurrences of LAS occurred during the season. Ankle-GO score was lower among injured ankles (16.9 +/- 3.6 points vs 19.6 +/- 3.2; P = .004; d = 0.8) and was associated with probability to sustain an LAS (AUC, 0.71; 95% CI, 0.57-0.84; P = .008). Athletes with an Ankle-GO score <19 points and those who suffered an LAS during the previous years were more likely to experience a new LAS on the same ankle (OR, 5.5; 95% CI, 1.6-19.2; P = .007, and OR, 3.5; 95% CI, 1.1-10.9; P = .03, respectively). CONCLUSION: The Ankle-GO score can help to identify elite basketball players who will suffer LAS during a competitive season. FAU - Hardy, Alexandre AU - Hardy A AD - Clinique du Sport Paris, Paris, France. FAU - Tassery, Francois AU - Tassery F AD - French Basketball Federation, Paris, France. FAU - Allaire, Thierry AU - Allaire T AD - French Basketball Federation, Paris, France. FAU - Moussa, Mohamad K AU - Moussa MK AUID- ORCID: 0000-0003-2611-3938 AD - Clinique du Sport Paris, Paris, France. AD - Groupe Hospitalier Selestat-Obernai, Selestat, France. FAU - Fourchet, Francois AU - Fourchet F AD - Physiotherapy Department, La Tour Hospital Swiss Olympic Medical Centre, Meyrin, Switzerland. AD - French Society of Sports Physical Therapist (SFMKS Lab), Pierrefitte-sur-Seine, France. FAU - Lopes, Ronny AU - Lopes R AD - Centre Orthopedique Santy, FIFA Medical Center of Excellence, Hopital Prive Jean Mermoz, Groupe Ramsay, Lyon, France. FAU - Picot, Brice AU - Picot B AD - French Society of Sports Physical Therapist (SFMKS Lab), Pierrefitte-sur-Seine, France. AD - University Savoie Mont Blanc, Laboratory Interuniversity of Human Movement Sciences, Chambery, France. LA - eng PT - Journal Article DEP - 20260210 PL - United States TA - Am J Sports Med JT - The American journal of sports medicine JID - 7609541 SB - IM MH - Humans MH - *Basketball/injuries MH - *Ankle Injuries/diagnosis/epidemiology MH - Prospective Studies MH - Male MH - Cross-Sectional Studies MH - Female MH - Adolescent MH - *Sprains and Strains/diagnosis/epidemiology MH - Risk Factors MH - Young Adult MH - Incidence OTO - NOTNLM OT - Ankle-GO OT - basketball OT - injury prevention OT - lateral ankle sprain OT - risk factors COIS- One or more of the authors has declared the following potential conflict of interest or source of funding: A.H. has received consulting fees from Arthrex and Depuy. R.L. is a consultant for Arthrex and a consultant and developer for Serf Extremity and Implant Service Orthopedie. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto. EDAT- 2026/02/10 13:32 MHDA- 2026/03/06 19:44 CRDT- 2026/02/10 10:03 PHST- 2026/03/06 19:44 [medline] PHST- 2026/02/10 13:32 [pubmed] PHST- 2026/02/10 10:03 [entrez] AID - 10.1177/03635465251410554 [doi] PST - ppublish SO - Am J Sports Med. 2026 Mar;54(3):678-685. doi: 10.1177/03635465251410554. Epub 2026 Feb 10. PMID- 41664686 OWN - NLM STAT- Publisher LR - 20260813 IS - 1556-3316 (Print) IS - 1556-3324 (Electronic) IS - 1556-3316 (Linking) VI - 22 IP - 3 DP - 2026 Feb 6 TI - Translation, Cross-Cultural Adaptation, and Psychometric Evaluation of the Hospital for Special Surgery Pediatric Functional Activity Brief Scale (HSS Pedi-FABS) for Turkish Children and Adolescents. PG - 15563316251412832 LID - 10.1177/15563316251412832 [doi] AB - BACKGROUND: Evaluating physical activity in children is crucial for determining functional limitations and promoting healthy growth. The Hospital for Special Surgery Pediatric Functional Activity Brief Scale (HSS Pedi-FABS) is a valid, concise tool that assesses activity levels of children and adolescents participating in sports. There is currently no validated Turkish version. PURPOSE: We sought to (1) translate and cross-culturally adapt the HSS Pedi-FABS into Turkish and (2) evaluate the scale's psychometric properties in a Turkish pediatric and adolescent population. METHODS: The HSS Pedi-FABS was translated and culturally adapted following established guidelines. Physically active, healthy, and Turkish-speaking children and adolescents aged 8 to 17 years were included in the study. The exclusion criteria were as follows: (1) orthopedic/neurological conditions limiting functional activity, (2) language difficulties that could limit comprehension, (3) cognitive impairments, (4) illiteracy, (5) major organ failure, (6) malignancy, and (7) refusal to participate. Psychometric evaluation included internal consistency (Cronbach's alpha), test-retest (t1-t2) reliability (intraclass correlation coefficient), construct validity (correlation with existing physical activity questionnaires), and floor/ceiling effects. RESULTS: Fifty-five participants were included in the study. The Turkish version of the HSS Pedi-FABS (Turkish HSS Pedi-FABS) showed good internal and excellent test-retest reliability. Construct validity was demonstrated with strong correlations between the Turkish questionnaire and comparator instruments. No floor or ceiling effects were found as the minimum score was observed in <15% of participants (5.5% at t1) and the maximum score was not observed. CONCLUSION: The Turkish HSS Pedi-FABS is a valid and reliable instrument for assessing physical activity in healthy children and adolescents. It can be used for both clinical and research purposes. LEVEL OF EVIDENCE: Level II: validation study. CI - (c) The Author(s) 2026. FAU - Benlidayi, Ilke Coskun AU - Benlidayi IC AUID- ORCID: 0000-0001-6517-5969 AD - Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Cukurova University, Adana, Turkey. FAU - Sariyildiz, Aylin AU - Sariyildiz A AUID- ORCID: 0000-0002-8835-4203 AD - Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Cukurova University, Adana, Turkey. FAU - Deniz, Volkan AU - Deniz V AUID- ORCID: 0000-0003-0779-7721 AD - Department of Physiotherapy and Rehabilitation, Tarsus University Faculty of Health Sciences, Mersin, Turkey. FAU - Sayici, Ezgi Nur AU - Sayici EN AUID- ORCID: 0009-0008-0686-8771 AD - Child Wellness Center, Cukurova University, Adana, Turkey. FAU - Jones, Ruth H AU - Jones RH AUID- ORCID: 0009-0006-3097-0747 AD - Pediatric Orthopedic Surgery Service, Hospital for Special Surgery, New York, NY, USA. FAU - Fabricant, Peter D AU - Fabricant PD AUID- ORCID: 0000-0002-8070-685X AD - Pediatric Orthopedic Surgery Service, Hospital for Special Surgery, New York, NY, USA. LA - eng PT - Journal Article DEP - 20260206 PL - United States TA - HSS J JT - HSS journal : the musculoskeletal journal of Hospital for Special Surgery JID - 101273938 PMC - PMC12882842 OTO - NOTNLM OT - adolescent OT - child OT - cross-cultural comparison OT - exercise OT - surveys and questionnaires OT - validation studies as topic COIS- The authors declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: Peter D. Fabricant, MD, MPH, reports relationships with BICMD, Inc, Clinical Orthopedics and Related Research, HSS ASC Development Network LLC, HS2 LLC, Joint Effort Administrative Services Organization LLC, Osso VR, and Springer Nature. The other authors declared no potential conflicts of interest. EDAT- 2026/02/10 06:31 MHDA- 2026/02/10 06:31 PMCR- 2027/02/06 CRDT- 2026/02/10 03:58 PHST- 2025/08/27 00:00 [received] PHST- 2025/11/18 00:00 [accepted] PHST- 2026/02/10 06:31 [medline] PHST- 2026/02/10 06:31 [pubmed] PHST- 2026/02/10 03:58 [entrez] PHST- 2027/02/06 00:00 [pmc-release] AID - 10.1177_15563316251412832 [pii] AID - 10.1177/15563316251412832 [doi] PST - aheadofprint SO - HSS J. 2026 Feb 6;22(3):15563316251412832. doi: 10.1177/15563316251412832. PMID- 41664575 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1598-6357 (Electronic) IS - 1011-8934 (Print) IS - 1011-8934 (Linking) VI - 41 IP - 6 DP - 2026 Feb 9 TI - Current Practices and Challenges in Pediatric Obesity Management (POM): A Nationwide Survey of Physicians in Korea. PG - e61 LID - 10.3346/jkms.2026.41.e61 [doi] LID - e61 AB - BACKGROUND: Childhood obesity is a critical public health issue that often persists into adulthood, posing significant treatment challenges. Establishing long-term healthy habits is essential, and South Korea has implemented various policies to manage pediatric obesity. However, a gap remains between policy, medical efforts, and actual outcomes. This study aimed to explore physicians' perspectives on clinical practices, awareness of governmental policies, and the key barriers and facilitators in pediatric obesity management (POM). METHODS: The questionnaire was developed through a comprehensive literature review and expert feedback, followed by a validity assessment and pilot study, resulting in a finalized 42-question version. Using a convenience sampling approach, 200 physicians specializing in pediatric obesity were recruited via academic societies and online channels. Data analysis involved descriptive statistics, presenting categorical data as frequencies and percentages, and continuous variables as averages. RESULTS: Among the 200 participating physicians, 87.5% were pediatricians. Most had over five years of experience, and more than half were affiliated with primary clinics. Counseling was the primary treatment approach, with liraglutide being the most commonly used medication. However, POM effectiveness was largely unsatisfactory, with 42.0% considering their efforts a "failure." Only 46.0% reported having institutional protocols, and training experiences varied by institution and region. Awareness and satisfaction with governmental policies were low, with limited recognition of national programs. Physicians emphasized the need for early childhood interventions and stronger medical involvement. Key priorities for improvement included better insurance reimbursement and stronger school partnerships. CONCLUSION: This study lays the groundwork for developing targeted strategies and policies to address the complex challenges of POM, ultimately improving health outcomes across all age groups, particularly children and adolescents. CI - (c) 2026 The Korean Academy of Medical Sciences. FAU - Lee, Yoon AU - Lee Y AUID- ORCID: 0000-0001-9521-3575 AD - Department of Pediatrics, Korea University Anam Hospital, Seoul, Korea. FAU - Shin, Minsoo AU - Shin M AUID- ORCID: 0000-0002-8438-937X AD - Department of Pediatrics, Korea University Ansan Hospital, Ansan, Korea. FAU - Chung, Sochung AU - Chung S AUID- ORCID: 0000-0002-7655-2691 AD - Department of Pediatrics, Konkuk University School of Medicine, Seoul, Korea. AD - Department of Pediatrics, Konkuk University Medical Center, Seoul, Korea. FAU - Jung, Jahye AU - Jung J AUID- ORCID: 0009-0000-0320-7013 AD - Division of Health Technology Assessment Research, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea. FAU - Sul, Ah-Ram AU - Sul AR AUID- ORCID: 0000-0003-0331-5529 AD - Division of Health Technology Assessment Research, National Evidence-based Healthcare Collaborating Agency, Seoul, Korea. ahramsul@neca.re.kr. FAU - Hong, Yong Hee AU - Hong YH AUID- ORCID: 0000-0002-4676-8483 AD - Department of Pediatrics, Soonchunhyang University Bucheon Hospital, Soonchunhyang University College of Medicine, Bucheon, Korea. hongyonghee@schmc.ac.kr. LA - eng GR - NECA-A-24-001/NECA/National Evidence-based Healthcare Collaborating Agency of the Republic of Korea/Korea GR - SCH/Soonchunhyang University/Korea PT - Journal Article DEP - 20260209 PL - Korea (South) TA - J Korean Med Sci JT - Journal of Korean medical science JID - 8703518 SB - IM MH - Humans MH - Republic of Korea MH - Surveys and Questionnaires MH - *Pediatric Obesity/prevention & control MH - Female MH - *Physicians/psychology MH - *Practice Patterns, Physicians' MH - Child MH - Male MH - Adult PMC - PMC12890466 OTO - NOTNLM OT - Korea OT - Pediatric Obesity OT - Physicians OT - Surveys and Questionnaires COIS- The authors have no potential conflicts of interest to disclose. EDAT- 2026/02/10 06:30 MHDA- 2026/02/10 06:31 PMCR- 2026/01/30 CRDT- 2026/02/10 03:03 PHST- 2025/03/03 00:00 [received] PHST- 2025/06/10 00:00 [accepted] PHST- 2026/02/10 06:31 [medline] PHST- 2026/02/10 06:30 [pubmed] PHST- 2026/02/10 03:03 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - 41.e61 [pii] AID - 10.3346/jkms.2026.41.e61 [doi] PST - epublish SO - J Korean Med Sci. 2026 Feb 9;41(6):e61. doi: 10.3346/jkms.2026.41.e61. PMID- 41664328 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2047-6310 (Electronic) IS - 2047-6302 (Print) IS - 2047-6302 (Linking) VI - 21 IP - 2 DP - 2026 Feb TI - Unravelling the Ties: How Attachment Styles and Emotion Regulation Fuel Emotional Eating in Youth With Obesity-A Clinical Sample Study. PG - e70095 LID - 10.1111/ijpo.70095 [doi] LID - e70095 AB - Emotional eating is critical in the development and maintenance of obesity among children and adolescents. While attachment's influence on emotional eating is increasingly recognised, little is known about how emotion regulation strategies mediate this, particularly in samples with obesity. This study examined how attachment dimensions affect emotional eating through different emotion regulation strategies in youths with obesity. 772 children and adolescents (ages 7-19) with obesity participated. Key variables were measured using validated questionnaires. Mediation effects were analysed through Structural Equation Modelling, with exploratory analyses assessing the role of the emotion regulation strategies diversity index and specific emotion regulation strategies. Higher attachment anxiety and avoidance were associated with greater emotional eating, both directly and indirectly through maladaptive emotion regulation strategies. Adaptive strategies did not show mediating effects. Attachment anxiety and avoidance increased the diversity of emotion regulation strategies, which was associated with higher emotional eating. Interventions may benefit from prioritising the effectiveness of these strategies and addressing maladaptive ones. Excessive diversity of emotion regulation strategies could reflect underlying difficulties and may be associated with higher emotional eating. A deeper understanding of the interplay between attachment and emotion regulation could inform more targeted approaches for preventing and treating obesity in youth. CI - (c) 2026 The Author(s). Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation. FAU - Gomez-Odriozola, Joana AU - Gomez-Odriozola J AUID- ORCID: 0000-0001-6004-4927 AD - Department of Clinical and Health Psychology & Research Methods, University of the Basque Country UPV/EHU, Donostia-San Sebastian, Spain. FAU - Braet, Jolien AU - Braet J AUID- ORCID: 0000-0001-8213-2565 AD - Department of Developmental, Personality, and Social Psychology, Ghent University, Ghent, Belgium. FAU - Verbiest, Ine AU - Verbiest I AUID- ORCID: 0000-0002-0854-0488 AD - Department of Developmental, Personality, and Social Psychology, Ghent University, Ghent, Belgium. FAU - Braet, Caroline AU - Braet C AUID- ORCID: 0000-0003-2458-287X AD - Department of Developmental, Personality, and Social Psychology, Ghent University, Ghent, Belgium. LA - eng GR - IT-1797-26/Eusko Jaurlaritza/ GR - PID2023-151085NB-I00/Ministerio de Ciencia e Innovacion/ GR - UES22/27/University of the Basque Country (UPV/EHU)/ GR - MOV23/42/University of the Basque Country (UPV/EHU)/ GR - BOF20/DOC/015/Bijzonder Onderzoeksfonds UGent (BOF)/ GR - FWO.3F0.2021.0087.01/Fonds Wetenschappelijk Onderzoek/ PT - Journal Article PL - England TA - Pediatr Obes JT - Pediatric obesity JID - 101572033 SB - IM MH - Humans MH - *Emotional Eating/psychology MH - Child MH - Adolescent MH - *Emotional Regulation MH - Female MH - Male MH - *Object Attachment MH - *Pediatric Obesity/psychology MH - Surveys and Questionnaires MH - Young Adult MH - *Feeding Behavior/psychology MH - Emotions PMC - PMC12887149 OTO - NOTNLM OT - attachment OT - emotion regulation OT - emotional eating OT - obesity OT - youth COIS- The hypotheses and data analysis plan are preregistered on the Open Science Framework under registration number: https://doi.org/10.17605/OSF.IO/FKQCM. The authors declare no conflicts of interest. EDAT- 2026/02/10 06:30 MHDA- 2026/02/10 06:31 PMCR- 2026/02/10 CRDT- 2026/02/10 00:32 PHST- 2026/01/27 00:00 [revised] PHST- 2025/02/14 00:00 [received] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/02/10 06:31 [medline] PHST- 2026/02/10 06:30 [pubmed] PHST- 2026/02/10 00:32 [entrez] PHST- 2026/02/10 00:00 [pmc-release] AID - IJPO70095 [pii] AID - 10.1111/ijpo.70095 [doi] PST - ppublish SO - Pediatr Obes. 2026 Feb;21(2):e70095. doi: 10.1111/ijpo.70095. PMID- 41664241 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260312 LR - 20260813 IS - 2210-9099 (Print) IS - 2233-6052 (Electronic) IS - 2210-9099 (Linking) VI - 17 IP - 1 DP - 2026 Feb TI - Correlates and co-occurrence of risk factors for non-communicable diseases among adolescents in schools in Karnataka, India: a cross-sectional study. PG - 83-93 LID - 10.24171/j.phrp.2025.0204 [doi] AB - BACKGROUND: Non-communicable disease (NCD) risk among adolescents represents a growing concern due to modifiable, lifestyle-related behavioral risk factors. Early identification and control of these factors are essential for prevention. This study assessed the correlates and cooccurrence of NCD-related lifestyle risk factors among school-going adolescents in Karnataka, India, aiming to inform intervention development. METHODS: Screening was conducted among 1,100 school adolescents aged 13-16 years from 8 randomly selected urban and rural schools in Karnataka. Data were collected using a validated self-administered questionnaire covering sociodemographic characteristics and social cognitive theory predictors of lifestyle practices. Descriptive statistics, chi-square tests, and logistic regression were employed. RESULTS: Of the 1,100 adolescents surveyed, 552 and 548 were from urban and rural areas, respectively. Both groups reported high rates of insufficient fruit and vegetable (FV) intake (96.7% and 67.7%, respectively), inadequate physical activity (96.7% and 68.6%), tobacco use (5.6% and 11.5%), and alcohol consumption (5.6% and 10.8%). On logistic regression, urban adolescents were significantly more likely than rural peers to exhibit multiple behavioral risk factors, with 19-fold higher odds of having >/=1 factor (adjusted odds ratio [AOR], 19.04; p< 0.001) and 4-fold higher odds of having >/=2 (AOR, 4.06; p < 0.001). Parental (particularly maternal) education was associated with NCD risk (AOR, 1.82; p= 0.001). Physical inactivity significantly co-occurred with low FV intake (71.7%) and junk food consumption (72.8%). CONCLUSION: Unhealthy lifestyle behaviors among adolescents displayed significant cooccurrence, underscoring the critical need for comprehensive, theory-based school interventions to address multiple interconnected risk factors and mitigate the burden of NCDs. FAU - Darukaradhya, Tejaswini Bangalore AU - Darukaradhya TB AD - Division of Public Health, Faculty of Life and Allied Health Sciences, M.S. Ramaiah University of Applied Sciences, Bengaluru, India. FAU - Jayanna, Krishnamurthy AU - Jayanna K AD - Center for Integrative Health and Wellbeing, Bengaluru, India. FAU - Somanna, Shivaraj Nallur AU - Somanna SN AD - Department of Community Medicine, Ramaiah Medical College, M.S. Ramaiah University of Applied Sciences, Bengaluru, India. FAU - Sequeira, Sony AU - Sequeira S AD - Division of Public Health, Faculty of Life and Allied Health Sciences, M.S. Ramaiah University of Applied Sciences, Bengaluru, India. FAU - Nooyi, Shalini Chandrashekar AU - Nooyi SC AD - Department of Community Medicine, Ramaiah Medical College, M.S. Ramaiah University of Applied Sciences, Bengaluru, India. LA - eng PT - Journal Article DEP - 20260210 PL - Korea (South) TA - Osong Public Health Res Perspect JT - Osong public health and research perspectives JID - 101563309 PMC - PMC12980643 OTO - NOTNLM OT - Adolescent OT - Health risk behaviors OT - Lifestyle OT - Noncommunicable diseases COIS- Conflicts of Interest The authors have no conflicts of interest to declare. EDAT- 2026/02/10 06:31 MHDA- 2026/02/10 06:32 PMCR- 2026/02/01 CRDT- 2026/02/10 00:21 PHST- 2025/06/10 00:00 [received] PHST- 2026/01/11 00:00 [accepted] PHST- 2026/02/10 06:32 [medline] PHST- 2026/02/10 06:31 [pubmed] PHST- 2026/02/10 00:21 [entrez] PHST- 2026/02/01 00:00 [pmc-release] AID - j.phrp.2025.0204 [pii] AID - j-phrp-2025-0204 [pii] AID - 10.24171/j.phrp.2025.0204 [doi] PST - ppublish SO - Osong Public Health Res Perspect. 2026 Feb;17(1):83-93. doi: 10.24171/j.phrp.2025.0204. Epub 2026 Feb 10. PMID- 41664228 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Feb 9 TI - Physical exercise and adolescent negative emotions: indirect associations via stress perception and emotional sensitivity. LID - 10.1186/s40359-026-04093-5 [doi] LID - 348 AB - BACKGROUND: Adolescent negative emotions are a major public health concern. Physical exercise is often associated with better emotional health, yet the psychological processes underlying this association, particularly in Chinese adolescents, are not fully understood. This study examined whether stress perception and emotional sensitivity are related to the association between physical exercise and negative emotions. METHODS: A cross-sectional survey was conducted with 1,471 adolescents (54.52% male; Mean age = 13.16, SD = 1.01) from ten middle schools in Guangxi Province, China. Validated Chinese versions of established instruments assessed physical exercise (Youth Physical Activity Rating Scale), negative emotions (PANAS Negative Affect subscale), stress perception (Perceived Stress Scale), and emotional sensitivity operationalized through emotional contagion susceptibility. Path analysis using maximum likelihood estimation with robust standard errors tested the hypothesized sequential mediation model. Bootstrap confidence intervals (5,000 resamples) evaluated indirect effects. RESULTS: Path analysis revealed good model fit (chi(2)/df = 3.62, CFI = 0.96, TLI = 0.94, SRMR = 0.05, RMSEA = 0.04). Physical exercise demonstrated significant direct (beta = -0.13, 95% CI [-0.22, -0.09]) and indirect (beta = -0.12, 95% CI [-0.27, -0.08]) associations with negative emotions. Stress perception accounted for 40% of the total association between physical exercise and negative emotions (beta = -0.10, 95% CI [-0.16, -0.07]). The sequential indirect association via stress perception and emotional sensitivity accounted for 8% of the total association (beta = -0.02, 95% CI [-0.05, -0.01]). The direct path from physical exercise to emotional sensitivity was non-significant (beta = -0.04, p = 0.23), which is consistent with an indirect-only pattern via stress perception in the specified model. CONCLUSIONS: The findings are consistent with a sequential mediation model in which physical exercise is associated with lower negative emotions both directly and indirectly, primarily through lower stress perception and, to a lesser extent, through a sequential pathway involving emotional sensitivity. Although the cross-sectional design does not permit causal conclusions, the observed pattern of associations highlights physical exercise and stress perception as important contextual factors to consider when developing strategies to support adolescent emotional health. FAU - Xin, Yang AU - Xin Y AD - Guangxi Orthopedic Hospital, Nanning, China. AD - Guangxi University, Nanning, China. FAU - Liuheng, Lu AU - Liuheng L AD - Guangxi Orthopedic Hospital, Nanning, China. luliuheng809@163.com. LA - eng GR - HESTCG202304/the Health and Emergency Skills Training Center of Guangxi/ GR - Z-A20220394/the Self-financed Scientific Research Project of the Health Commission of Guangxi Zhuang Autonomous Region/ PT - Journal Article DEP - 20260209 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Female MH - Adolescent MH - Cross-Sectional Studies MH - Male MH - *Emotions MH - *Exercise/psychology MH - Subjective Stress MH - China MH - *Stress, Psychological/psychology PMC - PMC12983937 OTO - NOTNLM OT - Adolescents OT - China OT - Emotional sensitivity OT - Negative emotions OT - Physical exercise OT - Stress perception COIS- Declarations. Ethics approval and consent to participate: The Ethics Committee of Guangxi Orthopedic Hospital approved this study (approval no. 20240701; Date: July 8, 2024). The study was conducted in accordance with the Declaration of Helsinki and relevant institutional guidelines and regulations. Written informed consent was obtained from the legal guardians of all participants prior to data collection, and assent was obtained from all participating adolescents. Participation was voluntary. Consent for publication: Not applicable. The manuscript does not contain any individual person's data in any form. Competing interests: The authors declare no competing interests. EDAT- 2026/02/10 06:32 MHDA- 2026/06/27 06:44 PMCR- 2026/02/09 CRDT- 2026/02/10 00:19 PHST- 2025/01/15 00:00 [received] PHST- 2026/01/28 00:00 [accepted] PHST- 2026/06/27 06:44 [medline] PHST- 2026/02/10 06:32 [pubmed] PHST- 2026/02/10 00:19 [entrez] PHST- 2026/02/09 00:00 [pmc-release] AID - 10.1186/s40359-026-04093-5 [pii] AID - 4093 [pii] AID - 10.1186/s40359-026-04093-5 [doi] PST - epublish SO - BMC Psychol. 2026 Feb 9;14(1):348. doi: 10.1186/s40359-026-04093-5. PMID- 41663998 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Feb 9 TI - Association between nutrient patterns and muscle mass, fat mass, and BMI among Iranian adolescents: a cross-sectional study. LID - 10.1186/s12889-026-26578-z [doi] LID - 885 AB - BACKGROUND: Nutrient patterns impact body composition. Adolescents with obesity and overweight are vulnerable to many metabolic diseases. This study aimed to examine the association between nutrient patterns and muscle mass, fat mass, and BMI in Iranian adolescents. METHODS: This cross-sectional study was conducted on 451 adolescents from four schools in Jahrom. The frequency and nutritional content of the diet, as well as information about body composition, economic status, and anthropometric measurements, were collected. RESULTS: Adolescents were classified into tertiles based on anthropometric indices. Eight major nutritional patterns were identified. High adherence to NP6 (rich in DHA and EPA) was significantly associated with higher odds of being in the second BMI tertile, showing a 190% increase in odds after full adjustment (OR 2.91; 95% CI 1.14-7.42). Moderate adherence to NP5 (rich in fat, MUFA, and sodium) was associated with a 138% increase in odds of being in the second muscle mass tertile in the fully adjusted model (OR 2.38; 95% CI 1.23-4.60). High adherence to NP3 (loaded with cysteine, selenium, magnesium, phosphorus, copper, and vitamin B9) was associated with a 115% increase in odds of being in the second muscle mass tertile after adjusting for confounders (OR 2.15; 95% CI 1.04-4.46). No significant associations were found between any nutritional patterns and fat mass tertiles. CONCLUSION: The current study identified eight distinct NPs. Adherence to NPs containing healthy nutrients was associated with greater odds of muscle mass in adolescents. Conversely, NPs enriched with EPA and DHA were associated with an increased odds of being in the second BMI tertile. Further research, particularly prospective studies, is needed to validate these findings. FAU - Rahmanian, Reza AU - Rahmanian R AUID- ORCID: 0009-0004-0125-5096 AD - Student research committee, School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran. AD - Department of Nutrition, School of Health and Nutrition, Yasuj University of Medical Sciences, Yasuj, Iran. FAU - Razeghi-Pirbasti, Ali AU - Razeghi-Pirbasti A AUID- ORCID: 0009-0003-7237-5784 AD - Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Shaygantabar, Mohsen AU - Shaygantabar M AUID- ORCID: 0009-0006-5483-9495 AD - Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Javaheri-Tafti, Fatemeh AU - Javaheri-Tafti F AUID- ORCID: 0009-0002-3299-2684 AD - Student Research Committee, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Jowshan, Mohammad-Reza AU - Jowshan MR AUID- ORCID: 0000-0001-8603-5674 AD - Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. AD - School of Paramedical, Gerash University of Medical Sciences, Gerash, Iran. FAU - Mohammadi-Sartang, Mohsen AU - Mohammadi-Sartang M AUID- ORCID: 0000-0002-1613-4893 AD - Department of Nutrition, School of Health and Nutrition, Yasuj University of Medical Sciences, Yasuj, Iran. dr.mohammadi.nut@gmail.com. LA - eng PT - Journal Article DEP - 20260209 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Adolescent MH - Iran/epidemiology MH - *Body Mass Index MH - Female MH - Male MH - *Body Composition MH - *Diet/statistics & numerical data MH - *Muscle, Skeletal MH - *Adipose Tissue PMC - PMC12990646 OTO - NOTNLM OT - Body composition OT - Dietary pattern OT - Nutrition OT - Nutrition pattern OT - Obesity COIS- Declarations. Ethics approval and consent to participate: The research was approved by the Ethics Committee of the National Nutrition and Food Technology Research Institute at Shahid Beheshti University of Medical Sciences, Iran (IR.SBMU.NNFTRI.REC.1403.016). The study adheres to the principles outlined in the Declaration of Helsinki. Written informed consent was obtained from all participants. For participants under 16 years of age, informed consent was also obtained from their parents or legal guardians before enrollment. All personal information about participants will be kept secure in a database. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/10 01:30 MHDA- 2026/06/27 06:46 PMCR- 2026/02/09 CRDT- 2026/02/09 23:59 PHST- 2025/11/19 00:00 [received] PHST- 2026/02/03 00:00 [accepted] PHST- 2026/06/27 06:46 [medline] PHST- 2026/02/10 01:30 [pubmed] PHST- 2026/02/09 23:59 [entrez] PHST- 2026/02/09 00:00 [pmc-release] AID - 10.1186/s12889-026-26578-z [pii] AID - 26578 [pii] AID - 10.1186/s12889-026-26578-z [doi] PST - epublish SO - BMC Public Health. 2026 Feb 9;26(1):885. doi: 10.1186/s12889-026-26578-z. PMID- 41663088 OWN - NLM STAT- MEDLINE DCOM- 20260813 LR - 20260813 IS - 1439-1651 (Electronic) IS - 0948-2393 (Linking) VI - 230 IP - 4 DP - 2026 Aug TI - Investigation of serum Agouti-related peptide levels in pregnant women with hyperemesis gravidarum. PG - 300-305 LID - 10.1055/a-2784-5204 [doi] AB - OBJECTIVE: Agouti-related peptide (AgRP) is an orexigenic neuropeptide secreted by the hypothalamus that plays a key role in stimulating appetite and increasing food intake. This study aimed to evaluate circulating AgRP levels in pregnant women diagnosed with hyperemesis gravidarum (HG). METHODS: This cross-sectional case-control study compared serum AgRP levels between two groups of pregnant women. The first group included 44 women aged 18-40 years who were hospitalized during the first trimester due to HG, while the control group consisted of 44 healthy pregnant women without HG, matched for age, body mass index (BMI), and gestational age. RESULTS: Both groups were similar in terms of age, BMI, gravida, parity, and gestational week at which blood samples were taken (p > 0.05 for all). Median serum AgRP level was 211.67 ng/L in the HG group and 182.14 ng/L in the control group (p=0.073). There was a significant positive correlation between AgRP level and maternal BMI as well as urinary ketone positivity (r=0.326, r=0.334, r=0.536, r=0.335; p<0.05, respectively). CONCLUSION: In this study, serum AgRP levels did not differ significantly between the HG and control groups. Although these findings should be interpreted with caution due to the limited sample size, they suggest that AgRP may not play a central role in the pathogenesis of HG. Further prospective studies with larger cohorts are warranted to better elucidate this potential association. CI - Thieme. All rights reserved. FAU - Erdogan, Melek AU - Erdogan M AUID- ORCID: 0009-0002-7012-7579 AD - Department of Gynecology and Obstetrics, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Koca Yildirim, Hande Esra AU - Koca Yildirim HE AUID- ORCID: 0000-0002-3715-9424 AD - Department of Gynecology and Obstetrics, Umraniye Training and Research Hospital, Istanbul, Turkey. FAU - Kale, Ibrahim AU - Kale I AUID- ORCID: 0000-0001-7802-7199 AD - Department of Gynecology and Obstetrics, Umraniye Training and Research Hospital, Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20260209 PL - Germany TA - Z Geburtshilfe Neonatol JT - Zeitschrift fur Geburtshilfe und Neonatologie JID - 9508901 RN - 0 (Agouti-Related Protein) RN - 0 (Biomarkers) RN - 0 (AGRP protein, human) SB - IM MH - Humans MH - Female MH - *Hyperemesis Gravidarum/blood/diagnosis/epidemiology MH - Pregnancy MH - *Agouti-Related Protein/blood MH - Adult MH - Young Adult MH - Biomarkers/blood MH - Case-Control Studies MH - Adolescent MH - Cross-Sectional Studies MH - Sensitivity and Specificity MH - Reproducibility of Results MH - Reference Values MH - Body Mass Index COIS- The authors declare that they have no conflict of interest. EDAT- 2026/02/10 01:29 MHDA- 2026/08/13 23:36 CRDT- 2026/02/09 19:52 PHST- 2026/08/13 23:36 [medline] PHST- 2026/02/10 01:29 [pubmed] PHST- 2026/02/09 19:52 [entrez] AID - 10.1055/a-2784-5204 [doi] PST - ppublish SO - Z Geburtshilfe Neonatol. 2026 Aug;230(4):300-305. doi: 10.1055/a-2784-5204. Epub 2026 Feb 9. PMID- 41663084 OWN - NLM STAT- MEDLINE DCOM- 20260824 LR - 20260917 IS - 1098-8785 (Electronic) IS - 0735-1631 (Linking) VI - 43 IP - 12 DP - 2026 Sep TI - Antenatal Estimation of Placental Weight and Its Relationship with Adverse Fetal Outcome. PG - 1640-1647 LID - 10.1055/a-2807-4332 [doi] AB - OBJECTIVE: This study aimed to estimate placental weight (EPW) antenatally in the third trimester and to evaluate its role in predicting adverse fetal outcome. STUDY DESIGN: A total of 190 antenatal women from 28 to 40 weeks of gestation, expected to deliver within 72 hours of examination, were included. The placental length, breadth, thickness, and estimated fetal weight (EFW) were noted in ultrasound. After delivery, the placental dimensions, including fetal weight, were recorded. The fetal outcome was noted. Multivariate regression was used for antenatal EPW calculation, and its correlation with actual placental weight (APW) was done. RESULTS: The mean age of women was 27.9 +/- 3.9 years. The mean estimated and actual placental lengths at term were 15.0 +/- 2.69 cm (range 9-22.8 cm) and 14.4 +/- 2.70 cm (range 8-21.2 cm). The Spearman coefficient of correlation (rho) between all placental dimensions was found to be statistically significant (p = 0.001); the best correlation was observed between EPW and APW (rho = 0.840). The centile chart of placental weight was drawn using multivariate regression analysis. The EPW and placental length was significantly less at all gestations in cases with adverse fetal outcome compared with normal outcome; however, the area under curve (AUC) for EPW at 30 to 34 weeks was the best (p = 960), taking the EPW cut-off of 345 g; the sensitivity and specificity of predicting adverse fetal outcome were 80 and 100%, respectively. CONCLUSION: To the best of our knowledge, it is the first study to attempt antenatal estimation of placental weight, and has shown it to be valuable in predicting adverse fetal outcome. KEY POINTS: . Novel study to attempt antenatal estimation of placental weight.. . Third trimester assessment of placental weight was done with good accuracy.. . Placental weight had good accuracy in predicting adverse fetal outcome.. CI - Thieme. All rights reserved. FAU - Yogi, Isha AU - Yogi I AD - Department of Obstetrics and Gynecology, Lady Hardinge Medical College, New Delhi, India. FAU - Kumar, Manisha AU - Kumar M AD - Department of Obstetrics and Gynecology, Lady Hardinge Medical College, New Delhi, India. FAU - Ravi, Vajala AU - Ravi V AD - Department of Statistics, Venkateshwara College, New Delhi, India. FAU - Nangia, Sushma AU - Nangia S AD - Department of Neonatology, Kalawati Saran Children's Hospital, New Delhi, India. FAU - Yadav, Reena AU - Yadav R AD - Department of Obstetrics and Gynecology, Lady Hardinge Medical College, New Delhi, India. LA - eng PT - Journal Article DEP - 20260209 PL - United States TA - Am J Perinatol JT - American journal of perinatology JID - 8405212 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Placenta/diagnostic imaging/anatomy & histology MH - Organ Size MH - *Ultrasonography, Prenatal MH - Pregnancy Trimester, Third MH - Adult MH - *Fetal Weight MH - Pregnancy Outcome MH - Gestational Age MH - Multivariate Analysis MH - Infant, Newborn MH - Young Adult MH - ROC Curve COIS- The authors declare that they have no conflict of interest. EDAT- 2026/02/10 01:29 MHDA- 2026/08/24 23:34 CRDT- 2026/02/09 19:52 PHST- 2026/08/24 23:34 [medline] PHST- 2026/02/10 01:29 [pubmed] PHST- 2026/02/09 19:52 [entrez] AID - 10.1055/a-2807-4332 [doi] PST - ppublish SO - Am J Perinatol. 2026 Sep;43(12):1640-1647. doi: 10.1055/a-2807-4332. Epub 2026 Feb 9. PMID- 41663064 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1678-4782 (Electronic) IS - 0021-7557 (Print) IS - 0021-7557 (Linking) VI - 102 IP - 2 DP - 2026 Mar-Apr TI - Lumbopelvic stabilization-based physiotherapy and rehabilitation and urotherapy for lower urinary tract dysfunction in Duchenne Muscular Dystrophy: a randomized controlled trial. PG - 101511 LID - S0021-7557(26)00013-6 [pii] LID - 10.1016/j.jped.2026.101511 [doi] LID - 101511 AB - OBJECTIVE: This randomized controlled trial investigated the effectiveness of supervised lumbopelvic stabilization and urotherapy on factors associated with lower urinary tract symptoms in children with Duchenne Muscular Dystrophy and lower urinary tract dysfunction (LUTD). METHOD: The study included 32 children aged 5-12 years, who were ambulatory and had a Dysfunctional Voiding and Incontinence Symptom Scale (DVISS) of 8.5 or higher. Lower urinary tract symptoms were assessed using the DVISS, a three-day bladder diary, and a nocturnal enuresis diary. Bowel symptoms were assessed with a seven-day bowel diary. Moreover, physical performance tests, the strength of pelvis-related muscle groups, and participation in activities of daily living were evaluated using validated measurement tools. Participants were randomized into two groups: the active control group (n:16, weight:25.81+/-9.53 kg, height:121.25+/-18.22 cm) received only urotherapy, while the treatment group (n:16, weight:25.88+/-9.67 kg, height: 122.69+/-16.63 cm) additionally performed lumbopelvic stabilization-based exercises for eight weeks under the supervision of a physiotherapist. RESULTS: Urotherapy significantly reduced LUTD severity (p < 0.001), enuresis frequency (p = 0.014), and the number of symptoms associated with LUTD (p = 0.001). However, adding lumbopelvic stabilization exercises conferred no superiority over urotherapy alone (p > 0.05). Supervised lumbopelvic stabilization improved functional mobility (p < 0.003), muscle strength (p < 0.05), and participation in activities of daily living (p < 0.049). However, neither urotherapy nor lumbopelvic stabilization training had a significant effect on Gower's time or daytime voiding frequency (p > 0.05). CONCLUSION: Both interventions were effective in improving bladder and bowel outcomes in children with Duchenne Muscular Dystrophy and LUTD, with no superiority observed on lower urinary tract symptoms. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Espana S.L.U. All rights reserved. FAU - Ozturk, Demet AU - Ozturk D AD - Lokman Hekim University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Ankara, Turkey. Electronic address: demet.ozturk@lokmanhekim.edu.tr. FAU - Ayse Karaduman, Aynur AU - Ayse Karaduman A AD - Lokman Hekim University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Ankara, Turkey. FAU - Akbayrak, Turkan AU - Akbayrak T AD - Hacettepe University, Faculty of Physical Therapy and Rehabilitation, Ankara, Turkey. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260213 PL - Brazil TA - J Pediatr (Rio J) JT - Jornal de pediatria JID - 2985188R SB - IM MH - Humans MH - Child MH - Male MH - *Muscular Dystrophy, Duchenne/complications MH - Child, Preschool MH - *Physical Therapy Modalities MH - *Lower Urinary Tract Symptoms/etiology/rehabilitation/therapy MH - Treatment Outcome MH - Female MH - Activities of Daily Living PMC - PMC12925434 OTO - NOTNLM OT - Duchenne muscular dystrophy OT - Lower urinary tract symptoms OT - Physical Therapy Modalities OT - Urotherapy COIS- Conflicts of interest The authors declare no conflicts of interest. EDAT- 2026/02/10 01:30 MHDA- 2026/03/28 00:42 PMCR- 2026/02/13 CRDT- 2026/02/09 19:20 PHST- 2025/09/17 00:00 [received] PHST- 2025/12/27 00:00 [revised] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/03/28 00:42 [medline] PHST- 2026/02/10 01:30 [pubmed] PHST- 2026/02/09 19:20 [entrez] PHST- 2026/02/13 00:00 [pmc-release] AID - S0021-7557(26)00013-6 [pii] AID - 101511 [pii] AID - 10.1016/j.jped.2026.101511 [doi] PST - ppublish SO - J Pediatr (Rio J). 2026 Mar-Apr;102(2):101511. doi: 10.1016/j.jped.2026.101511. Epub 2026 Feb 13. PMID- 41662908 OWN - NLM STAT- MEDLINE DCOM- 20260820 LR - 20260922 IS - 1553-4669 (Electronic) IS - 1553-4650 (Print) IS - 1553-4650 (Linking) VI - 33 IP - 8 DP - 2026 Aug TI - Diagnostic Disparities in Endometriosis and Adenomyosis: Investigating Social Vulnerability and Access to Care in an Ancestrally Diverse Population. PG - 1171-1179.e1 LID - S1553-4650(26)00104-4 [pii] LID - 10.1016/j.jmig.2026.02.010 [doi] AB - STUDY OBJECTIVE: To evaluate differences in the likelihood of endometriosis or adenomyosis diagnosis across genetically-defined ancestry groups (African, Admixed American, East Asian, European, and South Asian), and to determine whether social vulnerability and access to surgery influence diagnostic practices in a diverse urban population. SETTING: Penn Medicine BioBank, a clinical and genomic biorepository. PATIENTS: Female patients aged 18 to 51 enrolled from 2008 to 2020 and followed through March 2024. INTERVENTIONS: Population diversity was characterized using genotyping data from peripheral blood samples. Genetic ancestry was inferred through principal component analysis and clustering with reference populations. Sociocultural factors were assessed as distinct covariates rather than conflated with racial/ethnic identity. Social vulnerability indices (socioeconomic status, family/household factors, and housing/transportation access) were defined by Census tract of the patient's residence. Endometriosis and adenomyosis were identified using International Classification of Diseases-9/10 codes, validated by chart review. Logistic regressions were adjusted for age, body mass index, social vulnerability, and interaction terms. MEASUREMENTS AND MAIN RESULTS: Among 9258 patients, 357 (3.9%) were diagnosed with endometriosis and 464 (5.0%) with adenomyosis. When all diagnostic routes were considered (surgical, imaging, and clinical), the likelihood of endometriosis did not differ by ancestry group. However, the odds of a surgical diagnosis by laparoscopy was significantly lower for patients of African ancestry, compared with European (adjusted OR: 0.57, 95% CI: 0.38-0.85). Socioeconomic vulnerability strongly modified this association: African-ancestry patients with the highest socioeconomic vulnerability had the lowest odds of receiving an endometriosis diagnosis (aOR: 0.29, 0.14-0.61), including surgically confirmed diagnosis (aOR: 0.31, 0.12-0.80), relative to those of European ancestry with lowest vulnerability. By contrast, patients of African ancestry had higher odds of adenomyosis (aOR: 2.88, 2.16-3.85), including cases confirmed by hysterectomy (aOR: 3.44, 2.21-5.36). CONCLUSION: Diagnostic disparities in endometriosis and adenomyosis were most pronounced at the intersection of ancestry and socioeconomic vulnerability, highlighting the need to address social determinants and barriers to equitable care. CI - Copyright (c) 2026 AAGL. Published by Elsevier Inc. All rights reserved. FAU - Humphries, Leigh A AU - Humphries LA AD - Center for Minimally Invasive Gynecologic Surgery, Department of Obstetrics and Gynecology, Newton-Wellesley Hospital, Harvard Medical School, Newton, MA (Humphries). Electronic address: lahumphries@mgb.org. FAU - Rush, Margaret A AU - Rush MA AD - Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA (Rush, Senapati). FAU - Pollie, Meridith AU - Pollie M AD - Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA (Pollie). FAU - Guare, Lindsay AU - Guare L AD - Genomics and Computational Biology, University of Pennsylvania, Philadelphia, PA (Guare). FAU - Okeh, Chelsea AU - Okeh C AD - Interdisciplinary Graduate Program in Biological and Biomedical Sciences, Vanderbilt University School of Medicine, Nashville, TN (Okeh). CN - Penn Medicine BioBank AD - Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA (BioBank, Verma). FAU - Verma, Shefali Setia AU - Verma SS AD - Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA (BioBank, Verma); Department of Biostatistics, Epidemiology and Informatics, University of Pennsylvania, Philadelphia, PA (Verma). FAU - Senapati, Suneeta AU - Senapati S AD - Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Hospital of the University of Pennsylvania, Philadelphia, PA (Rush, Senapati). LA - eng GR - R01 HD110567/HD/NICHD NIH HHS/United States GR - T32 HG000046/HG/NHGRI NIH HHS/United States PT - Journal Article PT - Observational Study DEP - 20260208 PL - United States TA - J Minim Invasive Gynecol JT - Journal of minimally invasive gynecology JID - 101235322 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Middle Aged MH - Young Adult MH - *Adenomyosis/diagnosis/ethnology MH - *Endometriosis/diagnosis/ethnology MH - *Health Services Accessibility/statistics & numerical data MH - *Healthcare Disparities/ethnology/statistics & numerical data MH - *Social Vulnerability MH - Socioeconomic Disparities in Health MH - White/ethnology/statistics & numerical data MH - Black or African American/ethnology/statistics & numerical data MH - Asian/ethnology/statistics & numerical data PMC - PMC13267626 MID - NIHMS2146491 OTO - NOTNLM OT - Ancestral OT - Biobank OT - Genome sequencing OT - Gynecologic surgery OT - Health inequities OT - Healthcare access OT - Pelvic pain OT - Socioeconomic status EDAT- 2026/02/10 01:29 MHDA- 2026/08/21 03:31 PMCR- 2026/06/16 CRDT- 2026/02/09 19:10 PHST- 2025/12/04 00:00 [received] PHST- 2026/02/04 00:00 [revised] PHST- 2026/02/04 00:00 [accepted] PHST- 2026/08/21 03:31 [medline] PHST- 2026/02/10 01:29 [pubmed] PHST- 2026/02/09 19:10 [entrez] PHST- 2026/06/16 00:00 [pmc-release] AID - S1553-4650(26)00104-4 [pii] AID - 10.1016/j.jmig.2026.02.010 [doi] PST - ppublish SO - J Minim Invasive Gynecol. 2026 Aug;33(8):1171-1179.e1. doi: 10.1016/j.jmig.2026.02.010. Epub 2026 Feb 8. PMID- 41661994 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260209 LR - 20260213 IS - 2837-8156 (Electronic) IS - 2837-8156 (Linking) VI - 2 IP - 9 DP - 2025 TI - Investigating primary school educators' insights into attention deficit hyperactivity disorder: A cross sectional study in the Greater Accra Region, Ghana. PG - e0000376 LID - 10.1371/journal.pmen.0000376 [doi] LID - e0000376 AB - Schoolteachers play an integral role in the diagnosis and management of students with Attention Deficit/ Hyperactivity Disorder (ADHD). Despite its increased importance in Ghana, no study has been conducted to assess the knowledge and misperceptions of Ghanaian schoolteachers about ADHD. This study thus aimed to evaluate schoolteachers' level of knowledge and misperceptions about ADHD. This was a descriptive cross-sectional study conducted among teachers from eleven primary schools in the Greater Accra Region of Ghana from February to July 2023. A validated and self-administered questionnaire, comprising a demographic questionnaire and the Knowledge of Attention Deficit Disorder Scale (KADDS), was used to collect data on participants' sociodemographic characteristics, knowledge, and misperceptions about ADHD. Descriptive and inferential statistics were performed on the data using SPSS version. 26. Statistical significance was set at p = 0.05. The study included 170 participants, the majority being female (62.4%). The average percentage of knowledge regarding ADHD general knowledge, symptoms/diagnosis, and treatment was 32.29%, 40.92%, and 31.32%, respectively. The overall proportion of correct, incorrect, and "do not know" responses was 34.90%, 23.40%, and 41.70%, respectively. Common misconceptions included the belief that children with ADHD often outgrow the condition and that reducing dietary sugar alleviates symptoms. Educational background (p = 0.037), prior ADHD training (p = 0.005), and experience teaching an ADHD child (p = 0.003) were significantly associated with higher knowledge scores. There is a need for childhood mental health training among teachers and further research in this field in Ghana. CI - Copyright: (c) 2025 Diaba et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Diaba, Stephanie Eyram AU - Diaba SE AUID- ORCID: 0009-0004-9385-6939 AD - University of Ghana Medical School, University of Ghana, Accra, Ghana. FAU - Essuman, Yaw Akye AU - Essuman YA AUID- ORCID: 0009-0001-0179-4119 AD - University of Ghana Medical School, University of Ghana, Accra, Ghana. FAU - Singh, Gurinder AU - Singh G AD - Colchester East Hants Health Centre, Nova Scotia, Canada. FAU - Fiagbe, Delali AU - Fiagbe D AD - Department of Psychiatry, University of Ghana Medical School, University of Ghana, Accra, Ghana. LA - eng PT - Journal Article DEP - 20250903 PL - United States TA - PLOS Ment Health JT - PLOS mental health JID - 9918844789006676 PMC - PMC12798378 COIS- The authors have declared that no competing interests exist. EDAT- 2026/02/09 18:49 MHDA- 2026/02/09 18:50 PMCR- 2025/09/03 CRDT- 2026/02/09 12:34 PHST- 2025/02/15 00:00 [received] PHST- 2025/06/22 00:00 [accepted] PHST- 2026/02/09 18:50 [medline] PHST- 2026/02/09 18:49 [pubmed] PHST- 2026/02/09 12:34 [entrez] PHST- 2025/09/03 00:00 [pmc-release] AID - PMEN-D-25-00017 [pii] AID - 10.1371/journal.pmen.0000376 [doi] PST - epublish SO - PLOS Ment Health. 2025 Sep 3;2(9):e0000376. doi: 10.1371/journal.pmen.0000376. eCollection 2025. PMID- 41661812 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260209 LR - 20260926 IS - 2837-8156 (Electronic) IS - 2837-8156 (Linking) VI - 2 IP - 6 DP - 2025 TI - Multi-component interventions combining psychotherapy and physical activity for children and young peoples' mental health: A scoping review. PG - e0000227 LID - 10.1371/journal.pmen.0000227 [doi] LID - e0000227 AB - Multi-component mental health interventions, combining psychotherapy and physical activity (PA), have shown potential with adult populations, but their use with children and young people (CYP) remains unclear. This scoping review aimed to synthesize existing evidence on interventions that incorporate both psychotherapy and PA for CYP (4-18 years). Using Arksey and O'Malley's framework, and incorporating revisions from Levac, Colquhoun and O'Brien, Joanna Briggs Institute (JBI) methodology for scoping reviews, and PRISMA Extension for Scoping Reviews (PRISMA-ScR) recommendations, the review explored academic literature using five databases, as well as grey literature sources and clinical trial registries. Twenty-eight sources of evidence met the inclusion criteria and highlighted three main approaches to PA integration within the interventions: concurrent integration, asynchronous integration, and integration through PA planning and psychoeducation. A mixed pattern emerged, with six of twelve randomised controlled trials (RCTs) demonstrating statistically significant improvements in mental health and well-being outcomes. This review also raises critical questions about the development of theoretically grounded PA components and exploration of strategies for long-term sustainability and highlights the need for a structured approach to PA integration. Future research should prioritise understanding CYP's perspectives on the feasibility and acceptability of multi-component interventions. Addressing these areas will support the development of more robust and sustainable interventions, which could become vital in future CYP mental health initiatives. Overall, this review offers novel insights into the integration of psychotherapy and PA in CYP mental health interventions and informs future research and practice in this area. CI - Copyright: (c) 2025 D'Sa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - D'Sa, Maurelle AU - D'Sa M AUID- ORCID: 0009-0006-7865-9739 AD - Department of Social Work and Wellbeing, Faculty of Health, Social Care and Medicine, Edge Hill University, Ormskirk, Lancashire, United Kingdom. FAU - Relph, Nicola AU - Relph N AD - Department of Social Work and Wellbeing, Faculty of Health, Social Care and Medicine, Edge Hill University, Ormskirk, Lancashire, United Kingdom. FAU - Liverpool, Shaun AU - Liverpool S AUID- ORCID: 0000-0001-6419-8552 AD - Department of Social Work and Wellbeing, Faculty of Health, Social Care and Medicine, Edge Hill University, Ormskirk, Lancashire, United Kingdom. FAU - Tebble, Gary AU - Tebble G AUID- ORCID: 0000-0003-4137-7528 AD - Department of Social Work and Wellbeing, Faculty of Health, Social Care and Medicine, Edge Hill University, Ormskirk, Lancashire, United Kingdom. FAU - Owen, Michael AU - Owen M AUID- ORCID: 0000-0002-7960-2404 AD - Department of Social Work and Wellbeing, Faculty of Health, Social Care and Medicine, Edge Hill University, Ormskirk, Lancashire, United Kingdom. LA - eng PT - Journal Article DEP - 20250616 PL - United States TA - PLOS Ment Health JT - PLOS mental health JID - 9918844789006676 PMC - PMC12798439 COIS- The authors have declared that no competing interests exist. EDAT- 2026/02/09 18:49 MHDA- 2026/02/09 18:50 PMCR- 2025/06/16 CRDT- 2026/02/09 12:29 PHST- 2024/11/21 00:00 [received] PHST- 2025/05/20 00:00 [accepted] PHST- 2026/02/09 18:50 [medline] PHST- 2026/02/09 18:49 [pubmed] PHST- 2026/02/09 12:29 [entrez] PHST- 2025/06/16 00:00 [pmc-release] AID - PMEN-D-24-00548 [pii] AID - 10.1371/journal.pmen.0000227 [doi] PST - epublish SO - PLOS Ment Health. 2025 Jun 16;2(6):e0000227. doi: 10.1371/journal.pmen.0000227. eCollection 2025. PMID- 41661226 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1535-1815 (Electronic) IS - 0749-5161 (Linking) VI - 42 IP - 6 DP - 2026 Jun 1 TI - Optic Nerve Sheath Diameter in Pediatric Populations: Establishing Reference Intervals and Anthropometric Correlations. PG - 453-460 LID - 10.1097/PEC.0000000000003573 [doi] AB - OBJECTIVES: Ultrasonographic measurement of optic nerve sheath diameter (ONSD) is emerging as a noninvasive method for assessing intracranial pressure (ICP) in children. However, its practical application is limited by the lack of adequate age-specific normative data for healthy children. This study aimed to establish age-specific reference ranges for ONSD in healthy children aged 4 to 18 years and assess how anthropometric factors such as body mass index (BMI), height, and weight affect ONSD measurements. METHODS: This cross-sectional study included 150 healthy children aged 4 to 18 years, with no suspicion of increased ICP or chronic illness. ONSD was measured bilaterally using standardized transorbital ultrasonography. Anthropometric z -scores were calculated and correlations and percentile-based reference intervals were determined. RESULTS: The mean ONSD was 3.67+/-0.50 mm, with higher values in the 11 to 18 years group compared with the 4 to 10 years group (3.80+/-0.45 mm vs. 3.51+/-0.51 mm, P <0.001). ONSD positively correlated with age, height, weight, and BMI in the overall sample. Subgroup analyses revealed that BMI was significantly associated with ONSD only in the 11 to 18 years group. The age-specific 97th percentile upper limits were 4.33 mm (4 to 10 y) and 4.40 mm (11 to 18 y). CONCLUSIONS: This study provides age-specific normative reference intervals for ONSD in healthy children and shows the impact of BMI on ONSD measurements in adolescents. These findings enhance the clinical interpretation of ONSD in pediatric settings and support its integration into noninvasive ICP assessment protocols. Further multicenter studies are required to validate the reference values. CI - Copyright (c) 2026 Wolters Kluwer Health, Inc. All rights reserved. FAU - Erkan, Mine AU - Erkan M AUID- ORCID: 0000-0001-8612-356 AD - Akdeniz University Faculty of Medicine. FAU - Tolu Kendir, Ozlem AU - Tolu Kendir O AD - Akdeniz University Faculty of Medicine. FAU - Gurlu, Ramazan AU - Gurlu R AD - Antalya City Hospital, Antalya, Turkey. FAU - Erkek, Nilgun AU - Erkek N AD - Akdeniz University Faculty of Medicine. LA - eng PT - Journal Article DEP - 20260209 PL - United States TA - Pediatr Emerg Care JT - Pediatric emergency care JID - 8507560 SB - IM MH - Humans MH - Child MH - Adolescent MH - Reference Values MH - Female MH - Child, Preschool MH - Male MH - *Optic Nerve/diagnostic imaging/anatomy & histology MH - Cross-Sectional Studies MH - Ultrasonography/methods MH - Body Mass Index MH - Intracranial Pressure/physiology MH - Anthropometry MH - Age Factors OTO - NOTNLM OT - children OT - intracranial pressure OT - optic nerve sheath diameter (ONSD) OT - pediatric OT - reference ranges COIS- Disclosure: The authors declare no conflict of interest. EDAT- 2026/02/09 12:53 MHDA- 2026/06/01 12:39 CRDT- 2026/02/09 11:04 PHST- 2025/07/21 00:00 [received] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/06/01 12:39 [medline] PHST- 2026/02/09 12:53 [pubmed] PHST- 2026/02/09 11:04 [entrez] AID - 00006565-990000000-00789 [pii] AID - 10.1097/PEC.0000000000003573 [doi] PST - ppublish SO - Pediatr Emerg Care. 2026 Jun 1;42(6):453-460. doi: 10.1097/PEC.0000000000003573. Epub 2026 Feb 9. PMID- 41661161 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1827-1928 (Electronic) IS - 0022-4707 (Linking) VI - 66 IP - 5 DP - 2026 May TI - Somatotype, age, and neuromuscular performance in elite youth football players. PG - 631-641 LID - 10.23736/S0022-4707.25.17476-8 [doi] AB - BACKGROUND: Somatotype has been linked to physical performance in youth athletes, but its independent contribution to power development, particularly in relation to biological maturity, remains underexplored. This study examined whether somatotype and age independently influence neuromuscular performance in elite youth football players and whether these effects persist after normalization for body mass. METHODS: A total of 106 elite male academy players aged 15 to 18 years were classified as mesomorphic or ectomorphic using the Heath-Carter method. Performance tests included vertical jumps from a squat position and with countermovement, lower-limb peak power (estimated via a validated field equation), and an index estimating stretch-shortening cycle efficiency. Relative power (W.kg(-1)) was also calculated to account for body-mass dependence. Analyses included multivariate and variance testing, to explore independent effects of somatotype and age. RESULTS: Mesomorphic players produced significantly higher power output than ectomorphic players; older athletes also exhibited greater power. No interaction was observed between somatotype and age group. However, when normalized to body mass, between-group differences were no longer significant, indicating that the apparent mesomorphic advantage reflected greater mass rather than superior neuromuscular efficiency. No significant somatotype effect was observed for the Elasticity Index (P=0.098). Logistic regression correctly classified 72.6% of somatotypes, but specificity for ectomorphs was very low (11.5%), indicating that power-based profiling is ineffective for identifying ectomorphic players. CONCLUSIONS: Somatotype and age independently influence power performance in elite youth football players. Nevertheless, relative power analysis demonstrated that morphological differences primarily underlie these effects. Power metrics alone lack diagnostic validity for morphological classification and should complement, rather than replace, anthropometric assessment. FAU - Androulakis, Nikolaos AU - Androulakis N AD - Laboratory of Hematology, University Hospital of Iraklion, Iraklion, Greece - nikandgr@gmail.com. FAU - Tsiakiris, Christos AU - Tsiakiris C AD - Greek National U21 Team, Athens, Greece. FAU - Koundourakis, Nikolaos AU - Koundourakis N AD - Performance Department, O.F.I. Football Club, Iraklion, Greece. LA - eng PT - Journal Article DEP - 20260209 PL - Italy TA - J Sports Med Phys Fitness JT - The Journal of sports medicine and physical fitness JID - 0376337 SB - IM MH - Humans MH - Adolescent MH - Male MH - *Athletic Performance/physiology MH - *Somatotypes/physiology MH - Age Factors MH - *Muscle Strength/physiology MH - *Soccer/physiology MH - Exercise Test EDAT- 2026/02/09 12:54 MHDA- 2026/04/21 18:06 CRDT- 2026/02/09 10:45 PHST- 2026/04/21 18:06 [medline] PHST- 2026/02/09 12:54 [pubmed] PHST- 2026/02/09 10:45 [entrez] AID - S0022-4707.25.17476-8 [pii] AID - 10.23736/S0022-4707.25.17476-8 [doi] PST - ppublish SO - J Sports Med Phys Fitness. 2026 May;66(5):631-641. doi: 10.23736/S0022-4707.25.17476-8. Epub 2026 Feb 9. PMID- 41660763 OWN - NLM STAT- Publisher LR - 20260209 IS - 1532-530X (Electronic) IS - 1064-0266 (Linking) DP - 2026 Feb 9 TI - Prevention of eating disorders: 2025 in review. PG - 1-27 LID - 10.1080/10640266.2026.2622418 [doi] AB - This review of 15 prevention-related publications in Eating Disorders during 2025 is framed by three models: (1) Mental Health Intervention Spectrum: health promotion --> types of prevention --> case identification/referral for treatment; (2) the prevention cycle: rationale and theory, shaped by critical reviews --> clarifying risk and protective factors --> program innovation and feasibility studies --> efficacy and effectiveness research --> program dissemination; and (3) definitions of and links between eating disorder psychopathology, disordered eating behavior, and eating disorders. Four articles were categorized as prevention theory, methodology, or ethics; three articles were categorized as prevention rationale (including screening studies); six articles addressed correlates and putative risk factors for eating disorders or eating pathology; and one article each addressed protective factors and the upscaling/adaptation of the Body Project prevention program, respectively. Seven implications for prevention improvement are presented. For example, we must do more than acknowledge a spectrum of disordered eating. In many countries, eating pathology in girls and boys is a pressing public health problem that is almost certainly in place before age 13. Consequently, the developmental trajectories of eating pathology in children and adolescence, and the creation of effective school-based prevention programs for youth ages 10 through 15, are two under-studied areas that deserve research priority. FAU - Levine, Michael P AU - Levine MP AUID- ORCID: 0000-0002-4877-9995 AD - Department of Psychology (Emeritus), Kenyon College, Gambier, Ohio, USA. LA - eng PT - Journal Article DEP - 20260209 PL - United States TA - Eat Disord JT - Eating disorders JID - 9315161 SB - IM EDAT- 2026/02/09 12:53 MHDA- 2026/02/09 12:53 CRDT- 2026/02/09 07:23 PHST- 2026/02/09 12:53 [medline] PHST- 2026/02/09 12:53 [pubmed] PHST- 2026/02/09 07:23 [entrez] AID - 10.1080/10640266.2026.2622418 [doi] PST - aheadofprint SO - Eat Disord. 2026 Feb 9:1-27. doi: 10.1080/10640266.2026.2622418. PMID- 41660759 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260925 IS - 1557-0657 (Electronic) IS - 1049-8931 (Print) IS - 1049-8931 (Linking) VI - 35 IP - 1 DP - 2026 Mar TI - 'Digital Insight and Agency Scale' (DIAS): A Novel Tool to Illuminate Young People's Agency in Mitigating the Negative Impact of Digital Activities on Their Mental Health. PG - e70053 LID - 10.1002/mpr.70053 [doi] LID - e70053 AB - OBJECTIVES: Excessive time spent online is believed to negatively impact youth mental health; however, simplified screen-time measures fail to consider young people's agency and digital activity management skills. We developed and validated a novel tool, the Digital Insight and Agency Scale (DIAS), to better understand different aspects of young people's online agency and explore their links to youth mental health. METHODS: Participants (n = 383; age 16-25 years, mean = 19.0, SD = 1.7; 48.8% White, 30.2% South/East Asian, 8.6% Black) completed the DIAS questionnaire and standardised measures of anxiety, depression and wellbeing. The factor structure, reliability of the DIAS and associations with mental health were examined. RESULTS: Participants reported specific negative impacts of digital engagement on their daily functioning in the previous 2 weeks, especially less sleep. Seventy-eight per cent were worried about the negative impact of digital activity, and 82% engaged in one or more risk management actions, including Enhancing Positive Engagement, Coping Actions, and/or Reducing Engagement. Higher levels of mental health problems were associated with more worries and increased efforts to manage digital activity. CONCLUSIONS: Most young people displayed agency in managing their digital activity, suggesting that this could be leveraged in interventions, rather than focusing solely on reducing access and time spent online. CI - (c) 2026 The Author(s). International Journal of Methods in Psychiatric Research published by John Wiley & Sons Ltd. FAU - Tang, P AU - Tang P AD - Department of Psychology, School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK. AD - Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Kostyrka-Allchorne, K AU - Kostyrka-Allchorne K AD - Department of Psychology, School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK. FAU - Bourgaize, J AU - Bourgaize J AD - Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. AD - Clinical Outcome Solutions, Folkestone, UK. FAU - Murray, A AU - Murray A AD - School of Psychology, University of Edinburgh, Edinburgh, UK. FAU - Stoilova, M AU - Stoilova M AD - Department of Media and Communications, London School of Economics and Political Science, London, UK. FAU - Etherson, M E AU - Etherson ME AD - School of Health and Wellbeing, University of Glasgow, Glasgow, UK. FAU - Azeri, E AU - Azeri E AD - Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. FAU - Abbas, I AU - Abbas I AD - Department of Psychology, School of Biological and Behavioural Sciences, Queen Mary University of London, London, UK. FAU - Bridgwood, A AU - Bridgwood A AD - East London NHS Foundation Trust, London, UK. FAU - Hollis, C AU - Hollis C AD - National Institute of Health Research (NIHR) MindTech MedTech Research Centre, Institute of Mental Health, School of Medicine, University of Nottingham, Nottingham, UK. FAU - Townsend, E AU - Townsend E AD - School of Psychology, University of Nottingham, Nottingham, UK. FAU - Livingstone, S AU - Livingstone S AD - Department of Media and Communications, London School of Economics and Political Science, London, UK. FAU - Sonuga-Barke, E J S AU - Sonuga-Barke EJS AD - Department of Child and Adolescent Psychiatry, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK. CN - Digital Youth Research Programme LA - eng GR - MR/W002450/1/UK Research and Innovation/ PT - Journal Article PL - United States TA - Int J Methods Psychiatr Res JT - International journal of methods in psychiatric research JID - 9111433 SB - IM MH - Humans MH - Adolescent MH - Female MH - Young Adult MH - Male MH - Digital Media MH - Sense of Agency MH - Adult MH - *Psychometrics/instrumentation/standards MH - *Anxiety/diagnosis MH - *Depression/diagnosis MH - *Mental Health MH - Reproducibility of Results PMC - PMC12884440 OTO - NOTNLM OT - adolescence OT - agency OT - anxiety OT - coping OT - depression OT - digital risk perception and management COIS- The authors declare no conflicts of interest. EDAT- 2026/02/09 12:53 MHDA- 2026/02/09 12:54 PMCR- 2026/02/09 CRDT- 2026/02/09 07:13 PHST- 2025/12/15 00:00 [revised] PHST- 2025/10/16 00:00 [received] PHST- 2025/12/30 00:00 [accepted] PHST- 2026/02/09 12:54 [medline] PHST- 2026/02/09 12:53 [pubmed] PHST- 2026/02/09 07:13 [entrez] PHST- 2026/02/09 00:00 [pmc-release] AID - MPR70053 [pii] AID - 10.1002/mpr.70053 [doi] PST - ppublish SO - Int J Methods Psychiatr Res. 2026 Mar;35(1):e70053. doi: 10.1002/mpr.70053. PMID- 41660671 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260209 LR - 20260211 IS - 2056-5909 (Print) IS - 2056-5909 (Electronic) IS - 2056-5909 (Linking) VI - 32 DP - 2026 TI - A comparison of blood pressure reference values and the prevalence of high blood pressure in Indian adolescents aged 10-16 years using American and Indian reference standards. PG - e7 LID - 10.5646/ch.2026.32.e7 [doi] LID - e7 AB - BACKGROUND: High blood pressure (BP) in children and adolescents is a major public health concern globally, including in India. It is typically defined by BP > 95th percentile of normative BP distribution, with the American Academy of Pediatrics Clinical Practice Guidelines (AAP-CPG 2017) being most widely used. However, Indian-specific reference derived from healthy children set higher BP cut-offs than AAP-CPG 2017, leading to debate about their suitability. This study compares high BP prevalence using both references and examines how each classification by the 2 reference standards relates to cardiometabolic risk factors. METHODS: A secondary analysis of cross-sectional data from the Comprehensive National Nutrition Survey (2016-2018) was conducted to compare the prevalence of high BP in Indian adolescents aged 10-16 years using Indian and AAP-CPG 2017 references. The association between cardio-metabolic risk markers and high BP classified by these references was examined by survey weighted multiple log-binomial regression to examine the validity of each reference standard. RESULTS: In young adolescents aged 10-12 years, the prevalence of high BP was 16% (95% confidence interval [CI], 13.6-19%) and 33.6% (95% CI, 30.4-37%) by Indian and AAP-CPG reference respectively. Similarly, in older adolescents aged 13-16 years, the prevalence of high BP was lower with Indian reference. The adjusted risk ratios (ARRs) for high triglycerides, total cholesterol, and low-density lipoprotein were significantly elevated in young adolescents with high BP by AAP-CPG 2017 reference but not with Indian reference. CONCLUSIONS: The prevalence of high BP among Indian adolescents differed significantly based on the BP reference standard used. Clustering of cardiometabolic risk markers with high BP was observed when using the AAP-CPG reference but not with Indian reference. However, these findings should be interpreted cautiously given the cross-sectional study design with single visit BP measurement and limited generalizability of the Indian BP reference standard. Larger, nationally representative studies using standardized BP measurement methods are essential to establish validated BP norms for Indian adolescents. CI - Copyright (c) 2026 The Korean Society of Hypertension. FAU - Saji, Aswathi AU - Saji A AUID- ORCID: 0000-0002-8696-4083 AD - Research Scholar, Manipal Academy of Higher Education, Manipal, India. AD - Division of Epidemiology and Biostatistics, St. John's Research Institute, St. John's National Academy of Health Sciences (a Unit of CBCI Society for Medical Education), Bangalore, India. FAU - Thomas, Tinku AU - Thomas T AUID- ORCID: 0000-0002-1786-6076 AD - Department of Biostatistics, St. John's Medical College, Bengaluru, India. FAU - Sachdev, Harshpal Singh AU - Sachdev HS AUID- ORCID: 0000-0002-4956-9391 AD - Department of Pediatrics, Sitaram Bhartia Institute of Science and Research, New Delhi, India. FAU - Kurpad, Anura V AU - Kurpad AV AUID- ORCID: 0000-0001-7998-2438 AD - Department of Physiology, St. John's Medical College, Bengaluru, India. FAU - Vasudevan, Anil AU - Vasudevan A AUID- ORCID: 0000-0003-4338-0325 AD - Department of Pediatrics Nephrology, St. John's Medical College Hospital, Bengaluru, India. LA - eng PT - Journal Article DEP - 20260201 PL - Korea (South) TA - Clin Hypertens JT - Clinical hypertension JID - 101669508 PMC - PMC12875772 OTO - NOTNLM OT - Adolescents OT - Blood pressure nomogram or reference range OT - CNNS OT - Hypertension COIS- Competing interest: The authors declare that they have no competing interests. EDAT- 2026/02/09 12:54 MHDA- 2026/02/09 12:55 PMCR- 2026/02/01 CRDT- 2026/02/09 07:03 PHST- 2025/09/05 00:00 [received] PHST- 2025/12/09 00:00 [revised] PHST- 2025/12/22 00:00 [accepted] PHST- 2026/02/09 12:55 [medline] PHST- 2026/02/09 12:54 [pubmed] PHST- 2026/02/09 07:03 [entrez] PHST- 2026/02/01 00:00 [pmc-release] AID - 10.5646/ch.2026.32.e7 [doi] PST - epublish SO - Clin Hypertens. 2026 Feb 1;32:e7. doi: 10.5646/ch.2026.32.e7. eCollection 2026. PMID- 41660596 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2399-4908 (Electronic) IS - 2399-4908 (Linking) VI - 11 IP - 1 DP - 2026 TI - Identifying local priorities for research with linked routine data: an online workshop method. PG - 3045 LID - 10.23889/ijpds.v11i1.3045 [doi] LID - 3045 AB - INTRODUCTION: Priority setting with patients, public and professionals is essential for research utilising routinely collected data, as this ensures data are being used in the public interest. However, it is challenging to identify research priorities that are relevant to a wide range of local stakeholders and can be addressed with routinely collected data. OBJECTIVES: To describe and present the results of a priority setting exercise aiming to identify research priorities for Born in Bradford for All (BiB4All), a routine data linkage cohort of mothers and babies born in Bradford, a city in the north of England. METHODS: We developed a two-hour online workshop to engage a range of stakeholders across Bradford, including parents, early years practitioners, commissioners, and service providers. The workshop method combined elements of existing priority setting approaches to ensure priorities were identified in an inclusive, timely and deliberative way, and supported stakeholders to develop their understanding of using linked routine data for research. RESULTS: The workshop identified seventeen important and urgent research priorities around child and maternal health for research with locally linked routine data. Key topic areas included maternal and infant mental health, the long-term impact of the Covid-19 pandemic on maternal and child health outcomes, inequalities in access to services, and infant feeding experiences. CONCLUSIONS: The identified research priorities have been shared widely amongst interested networks and have shaped the BiB4All research agenda, demonstrating the feasibility of the stakeholder engagement method. They also have important implications for policy and practice. For policy, they provide an understanding of the key issues faced by local communities, which can steer policy priorities and investment in evidence generation. For practice, involvement in the workshop has generated a greater understanding of how local service data can be used for research and to inform improvements to service delivery. FAU - Henderson, Hollie AU - Henderson H AD - Department of Health Sciences, Seebohm Rowntree Building, University of York, Heslington, York, North Yorkshire, YO10 5DD, United Kingdom. AD - Born in Bradford, Bradford Institute For Health Research, Bradford Royal Infirmary, Duckworth Lane, Bradford, West Yorkshire, BD9 6RJ, United Kingdom. FAU - Bridges, Sally AU - Bridges S AD - Born in Bradford, Bradford Institute For Health Research, Bradford Royal Infirmary, Duckworth Lane, Bradford, West Yorkshire, BD9 6RJ, United Kingdom. FAU - Bryant, Maria AU - Bryant M AD - Department of Health Sciences, Seebohm Rowntree Building, University of York, Heslington, York, North Yorkshire, YO10 5DD, United Kingdom. AD - Hull York Medical School, University of York, Heslington, York, North Yorkshire, YO10 5DD, United Kingdom. FAU - Ciesla, Kayley AU - Ciesla K AD - Born in Bradford, Bradford Institute For Health Research, Bradford Royal Infirmary, Duckworth Lane, Bradford, West Yorkshire, BD9 6RJ, United Kingdom. FAU - Pickett, Kate AU - Pickett K AD - Department of Health Sciences, Seebohm Rowntree Building, University of York, Heslington, York, North Yorkshire, YO10 5DD, United Kingdom. LA - eng PT - Journal Article DEP - 20260129 PL - Wales TA - Int J Popul Data Sci JT - International journal of population data science JID - 101737740 SB - IM MH - Humans MH - Female MH - England MH - *Research MH - *Health Priorities MH - Maternal Health MH - COVID-19/epidemiology MH - Child Health MH - *Routinely Collected Health Data MH - Infant MH - Education PMC - PMC12880541 OTO - NOTNLM OT - BaBi Network OT - Born in Bradford OT - child health OT - linked data OT - maternal health OT - research priorities OT - routine data OT - stakeholder involvement COIS- Statements of conflicts of Interest: No conflicts of interest were declared. EDAT- 2026/02/09 12:54 MHDA- 2026/02/09 12:55 PMCR- 2026/01/29 CRDT- 2026/02/09 07:02 PHST- 2026/02/09 12:55 [medline] PHST- 2026/02/09 12:54 [pubmed] PHST- 2026/02/09 07:02 [entrez] PHST- 2026/01/29 00:00 [pmc-release] AID - 11:1:3045 [pii] AID - 10.23889/ijpds.v11i1.3045 [doi] PST - epublish SO - Int J Popul Data Sci. 2026 Jan 29;11(1):3045. doi: 10.23889/ijpds.v11i1.3045. eCollection 2026. PMID- 41660414 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260209 LR - 20260211 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 13 DP - 2026 TI - The influence of sustainable sport nutrition practices on youth sports participants. PG - 1730987 LID - 10.3389/fnut.2026.1730987 [doi] LID - 1730987 AB - BACKGROUND: Sustainable sports nutrition is increasingly recognized as a means of enhancing the athlete's performance while reducing negative environmental impacts, however, empirical data in the context of adolescent athletes is limited. OBJECTIVES: This study examined sport nutrition knowledge, environmental awareness, and sustainable dietary behaviors among adolescent athletes, and their associated with motivation and sports participation. METHODS: A mixed-methods design was used to examine sustainable nutrition behaviors and their motivational, contextual, and social determinants. A total of 312 athletes were invited to participate, and 120 completed a structured survey (response rate: 38%). Measures included a modified Sport Nutrition Knowledge Questionnaire, a validated environmental awareness subscale (alpha > 0.78), and a composite Sustainable Practice Score (SPS; alpha = 0.81). RESULTS AND DISCUSSION: Quantitative analyses showed that 78% of the participants reported moderate awareness of the environmental impact of food choices, and 62% had adopted at least one sustainable dietary practice. SPS was positively correlated with sports nutrition knowledge (r = 0.39, p < 0.001) and environmental awareness (r = 0.46, p < 0.001). Regression analyses indicated that sustainable nutrition practices significantly predicted motivation (beta = 0.32, p < 0.01) and participation frequency (beta = 0.29, p < 0.01), with environmental awareness moderating both relationships. Qualitative findings highlighted perceived physiological benefits, social influences, and structural barriers as a key theme influencing adoption. CONCLUSION: In general, adolescent athletes demonstrated developing and context-dependent sustainable dietary behaviors shaped by nutrition knowledge, environmental awareness, and socio-cultural influences. Enhancing sustainability-oriented educational interventions within youth sport settings may support both performance-related outcomes and the development of environmental responsibility. CI - Copyright (c) 2026 Deng. FAU - Deng, Jianfeng AU - Deng J AD - Guangzhou Songtian Polytechnic College, Guangzhou, China. LA - eng PT - Journal Article DEP - 20260123 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12877401 OTO - NOTNLM OT - China OT - athletes OT - environmental awareness OT - health performance OT - sports participation OT - sustainable nutrition COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/09 12:54 MHDA- 2026/02/09 12:55 PMCR- 2026/01/23 CRDT- 2026/02/09 07:00 PHST- 2025/10/23 00:00 [received] PHST- 2026/01/04 00:00 [revised] PHST- 2026/01/07 00:00 [accepted] PHST- 2026/02/09 12:55 [medline] PHST- 2026/02/09 12:54 [pubmed] PHST- 2026/02/09 07:00 [entrez] PHST- 2026/01/23 00:00 [pmc-release] AID - 10.3389/fnut.2026.1730987 [doi] PST - epublish SO - Front Nutr. 2026 Jan 23;13:1730987. doi: 10.3389/fnut.2026.1730987. eCollection 2026. PMID- 41660094 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Comparison of the performance of a Three-Dimensional Body Scanner and radiography in evaluating adult scoliosis. PG - e20752 LID - 10.7717/peerj.20752 [doi] LID - e20752 AB - BACKGROUND: Adult scoliosis, which is characterized by a persistent lateral deviation of the spine of at least 10 degrees in the frontal plane along with vertebral rotation in adulthood, can result from various causes, including degenerative changes, untreated childhood scoliosis, spinal trauma, and prior surgeries. Traditionally, spinal curvature is assessed by measuring the Cobb angle via radiographic imaging; however, concerns over radiation exposure have prompted exploration of alternative diagnostic tools.This study aims to evaluate the effectiveness of a newly developed three-dimensional (3D) body scanner, equipped with 12 depth cameras, in assessing spinal alignment and measuring the Cobb angle in patients with adult scoliosis, in comparison with radiographic imaging. METHODS: In this prospective cohort study, 40 patients with adult scoliosis-both idiopathic and degenerative-underwent evaluation using both radiographic imaging and 3D body scanning. Cobb angles were measured by both methods. Pearson and Spearman's rank correlation coefficients were calculated to assess the linear and monotonic relationships between measurements. Measurement accuracy was quantified using the mean bias from Bland-Altman analysis and spatial agreement of spinal positions was further evaluated using the Intersection over Union (IoU) metric. Univariable and multivariable regression analyses were performed to assess whether body habitus (body mass index, waist circumference, waist-to-height ratio, age, and sex) influenced the absolute error between 3D body scanner-predicted and radiographic Cobb angles. RESULTS: Cobb angle measurements obtained from 3D body scanning were highly correlated with those from radiography (Pearson r = 0.92, P < 0.001; Spearman rho = 0.85, P < 0.001), indicating strong linear and monotonic agreement. Bland-Altman analysis showed a small mean bias of -1.06 (95% limits of agreement: -10.25 to 8.12). The average IoU was 0.89, indicating substantial spatial agreement in spinal position predictions. Importantly, obesity indices (body mass index, waist circumference, waist-to-height ratio) were not significantly associated with the absolute error between 3D body scanner-predicted and radiographic Cobb angles in either univariable or multivariable analyses. CONCLUSIONS: The 3D body scanner exhibits promise for assessing spinal alignment and measuring the Cobb angle in patients with adult scoliosis, offering a reliable alternative to traditional radiographic methods. Its accuracy was not affected by obesity-related indices, supporting its applicability across diverse patient body types. Future research should focus on refining scanning protocols and integrating patient-reported outcomes to enhance clinical utility. CI - (c)2026 Kuo et al. FAU - Kuo, Ting-Ju AU - Kuo TJ AD - Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, New Taipei City, Taiwan. AD - Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan. FAU - Yu, Chin-Yin AU - Yu CY AD - Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, New Taipei City, Taiwan. FAU - Lin, Jui-Chi AU - Lin JC AD - Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, New Taipei City, Taiwan. FAU - Lin, Chien-Min AU - Lin CM AD - Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan. AD - Department of Neurological Surgery, Shuang Ho Hospital, New Taipei City, Taiwan. AD - Department of Surgery, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. FAU - Liou, Tsan-Hon AU - Liou TH AD - Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. AD - Department of Physical Medicine and Rehabilitation, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan. FAU - Peng, Chih-Wei AU - Peng CW AD - Biomedical Engineering, Taipei Medical University, Taipei, Taiwan. AD - School of Gerontology Health Management, College of Nursing, Taipei Medical University, Taipei, Taiwan. FAU - Chen, Hung-Chou AU - Chen HC AD - Department of Physical Medicine and Rehabilitation, Shuang Ho Hospital, New Taipei City, Taiwan. AD - Taipei Neuroscience Institute, Taipei Medical University, Taipei, Taiwan. AD - Department of Physical Medicine and Rehabilitation, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. AD - Center for Evidence-Based Health Care, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260203 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - *Scoliosis/diagnostic imaging MH - *Imaging, Three-Dimensional/instrumentation/methods MH - Female MH - Prospective Studies MH - Adult MH - Male MH - Middle Aged MH - *Radiography/methods MH - Aged MH - Spine/diagnostic imaging PMC - PMC12880093 OTO - NOTNLM OT - 3D body scanner OT - Cobb angle OT - Scoliosis OT - Surface topography COIS- The authors declare there are no competing interests. EDAT- 2026/02/09 12:54 MHDA- 2026/02/09 12:55 PMCR- 2026/02/03 CRDT- 2026/02/09 06:58 PHST- 2025/07/15 00:00 [received] PHST- 2025/12/16 00:00 [accepted] PHST- 2026/02/09 12:55 [medline] PHST- 2026/02/09 12:54 [pubmed] PHST- 2026/02/09 06:58 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - 20752 [pii] AID - 10.7717/peerj.20752 [doi] PST - epublish SO - PeerJ. 2026 Feb 3;14:e20752. doi: 10.7717/peerj.20752. eCollection 2026. PMID- 41660067 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Exploring the mediating role of physical activity levels in the relationship between physical literacy and physical fitness in Chinese university students. PG - e20689 LID - 10.7717/peerj.20689 [doi] LID - e20689 AB - OBJECTIVE: This study investigated the relationships between physical literacy (PL), physical activity levels (PALs), and physical fitness among Chinese university students, with a particular focus on the mediating role of PALs and the consistency of findings across various analytical methods. METHODS: Participants included 115 first-year students (79 males, 36 females) from Nanjing, China. PL was assessed using the Perceived Physical Literacy Instrument (PPLI-SC), PALs were measured using the Physical Activity Questionnaire for Adolescents (PAQ-A), and physical fitness was assessed through four indicators: body mass index (BMI), 50-m sprint, sit-and-reach, and 800/1,000-m run. Descriptive statistics, correlation, and regression analyses were conducted in SPSS 26.0. Mediation was tested using the PROCESS macro (Model 4, 5,000 bootstrap samples), and structural equation modeling (SEM) was applied using AMOS 26.0 for validation. RESULTS: Males outperformed females in the 50-m sprint, while females exhibited superior flexibility and cardiorespiratory endurance; BMI was significantly higher in males (p < 0.01). PL was positively correlated with PALs (r = 0.584, p < 0.01), and both were significantly associated with all fitness indicators except BMI. Mediation analyses indicated that PALs fully mediated the associations between PL and sprint performance, flexibility, and cardiorespiratory endurance. For BMI, the PROCESS macro suggested a weak indirect effect, whereas SEM results were nonsignificant, highlighting the sensitivity of the results to the analytical method used. CONCLUSION: PL is strongly linked to physical fitness in Chinese university students, with PALs acting as a critical mediator. The inconsistent BMI findings underscore its complex determinants, which extend beyond physical activity. Promoting PL and PALs through university physical education programs may improve fitness outcomes. Future research should validate these findings using larger samples, longitudinal designs, and broader body composition indicators (e.g., body fat percentage, muscle mass). CI - (c)2026 Sun and Hu. FAU - Sun, Yingshuang AU - Sun Y AD - Department of Physical Education, Suzhou Institute of Industrial Technology, Suzhou, China. FAU - Hu, Donglin AU - Hu D AD - College of Sports Industry and Leisure, Nanjing Sport Institute, Nanjing, Jiangsu Province, China. AD - Department of Physical Education, Nanjing Agricultural University, Nanjing, Jiangsu Province, China. AD - School of Physical Education and Educational Science, Tianjin University of Sport, Tianjin, China. LA - eng PT - Journal Article DEP - 20260203 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - Male MH - Female MH - *Physical Fitness/physiology MH - *Students/statistics & numerical data MH - China MH - Universities MH - *Exercise MH - Adolescent MH - Body Mass Index MH - Young Adult MH - Surveys and Questionnaires MH - *Health Literacy PMC - PMC12880097 OTO - NOTNLM OT - Mediation OT - Physical activity OT - Physical fitness OT - Physical literacy OT - University students COIS- The authors declare there are no competing interests. EDAT- 2026/02/09 12:54 MHDA- 2026/02/09 12:55 PMCR- 2026/02/03 CRDT- 2026/02/09 06:58 PHST- 2025/10/09 00:00 [received] PHST- 2025/12/08 00:00 [accepted] PHST- 2026/02/09 12:55 [medline] PHST- 2026/02/09 12:54 [pubmed] PHST- 2026/02/09 06:58 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - 20689 [pii] AID - 10.7717/peerj.20689 [doi] PST - epublish SO - PeerJ. 2026 Feb 3;14:e20689. doi: 10.7717/peerj.20689. eCollection 2026. PMID- 41660063 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260209 LR - 20260211 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 7 DP - 2025 TI - Development of the physical education knowledge questionnaire-Spain (PEKQ-S): feasibility, validity and reliability for Spanish children aged 6-12 years. PG - 1737905 LID - 10.3389/fspor.2025.1737905 [doi] LID - 1737905 AB - PURPOSE: Physical literacy (PL) encompasses the motivation, confidence, physical competence, and knowledge necessary for engaging in physical activity throughout one's life. Although tools such as the Canadian Assessment Physical Literacy (CAPL-2) assess PL globally, they lack cultural alignment with the Spanish context in terms of their cognitive components. This emphasizes the importance of developing a context-specific tool for assessing PL-related knowledge in Spanish primary education. This study aims to develop and validate the Physical Education Knowledge Questionnaire-Spain (PEKQ-S) for children aged 6-12, aligning it with the national physical education (PE) curriculum and evaluating its factor structure and reliability. METHODS: The PEKQ-S was developed through curriculum review, expert consultation, and student input via open-ended and closed-ended questions. Its feasibility and reliability were tested in 145 Spanish primary school children aged 6-12, and its structure was evaluated via exploratory factor analysis. RESULTS: Exploratory factor analysis identified two correlated factors across nine items. The PEKQ-S showed acceptable internal consistency [Cronbach's alpha (alpha) = 0.508-0.832] and fair to substantial test-retest reliability [intra-class correlation coefficient (ICC) = 0.337-0.696]. Moderate correlations were found between factors (r = 0.362), and most items demonstrated good reproducibility and stability. CONCLUSION: The PEKQ-S is a valid, reliable, and feasible tool for assessing PE-related knowledge linked to the PL in Spanish children aged 6-12. It represents the first instrument of its kind in Spain and forms part of the Spanish Physical Literacy Assessment for Children (SPLA-C) model. CI - (c) 2026 Pastor-Cisneros, Mendoza-Munoz, Lopez-Gil and Carlos-Vivas. FAU - Pastor-Cisneros, Raquel AU - Pastor-Cisneros R AD - Physical Activity for Education, Performance and Health (PAEPH) Research Group, Faculty of Sport Sciences, University of Extremadura, Caceres, Spain. FAU - Mendoza-Munoz, Maria AU - Mendoza-Munoz M AD - Department of Communication and Education, Universidad Loyola Andalucia, Sevilla, Spain. FAU - Lopez-Gil, Jose Francisco AU - Lopez-Gil JF AD - School of Medicine, Universidad Espiritu Santo, Samborondon, Ecuador. AD - Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno, Chile. FAU - Carlos-Vivas, Jorge AU - Carlos-Vivas J AD - Physical Activity for Education, Performance and Health (PAEPH) Research Group, Faculty of Sport Sciences, University of Extremadura, Caceres, Spain. LA - eng PT - Journal Article DEP - 20260123 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC12876181 OTO - NOTNLM OT - SPLA-C OT - assessment OT - physical activity OT - physical literacy OT - validation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/09 12:53 MHDA- 2026/02/09 12:54 PMCR- 2026/01/23 CRDT- 2026/02/09 06:57 PHST- 2025/11/02 00:00 [received] PHST- 2025/12/29 00:00 [revised] PHST- 2025/12/30 00:00 [accepted] PHST- 2026/02/09 12:54 [medline] PHST- 2026/02/09 12:53 [pubmed] PHST- 2026/02/09 06:57 [entrez] PHST- 2026/01/23 00:00 [pmc-release] AID - 10.3389/fspor.2025.1737905 [doi] PST - epublish SO - Front Sports Act Living. 2026 Jan 23;7:1737905. doi: 10.3389/fspor.2025.1737905. eCollection 2025. PMID- 41657913 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260211 IS - 2328-8930 (Print) IS - 2328-8930 (Electronic) VI - 12 IP - 12 DP - 2025 Dec 9 TI - Prenatal Exposure to Emerging Pesticides and Childhood Allergy Risk: A Mixture Assessment in an Urban Birth Cohort. PG - 1611-1617 LID - 10.1021/acs.estlett.5c00836 [doi] AB - Pesticide gestational exposure may contribute to the development of allergies in childhood, yet evidence on its health impact on urban populations remains limited. This study investigates the association between prenatal exposure to individual and mixed pesticides and allergic outcomes, including asthma, wheezing, and eczema, at age 6 in 387 mother-child pairs from the German prospective cohort LiNA. Forty pesticides and metabolites were detected in urine during pregnancy through nontargeted screening, and 11 were selected (detection rate >/= 17%) for further analysis. Multivariable logistic regression models adjusted for covariates revealed statistically significant associations between dihydroxy-pyrimethanil and asthma (aOR = 1.35, 95% CI: 1.02-1.79), and fluazifop-desbuthyl and wheezing (aOR = 1.14, 95% CI: 1.01-1.30). No significant associations were observed for eczema. The weighted quantile sum (WQS) regression showed that higher pesticide coexposures significantly increased wheezing odds (aOR = 2.08, 95% CI: 1.21-3.56). The main components of the WQS index were fluazifop-desbuthyl, flonicamid, hydroxy-metazachlor, and terbuthylazine, accounting for 67% of the overall mixture effect. These findings suggest that prenatal exposure to pesticides, likely from dietary sources, may increase the risk of childhood asthma and wheezing. Replication studies in populations with comparable pesticide exposures, along with experimental mechanistic validation, will strengthen the understanding of the observed associations. CI - (c) 2025 The Authors. Published by American Chemical Society. FAU - Gomez-Olarte, Sergio AU - Gomez-Olarte S AUID- ORCID: 0000-0002-9494-068X AD - Department of Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig 04318, Germany. RINGGOLD: 28342 FAU - Roder, Stefan AU - Roder S AD - Department of Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig 04318, Germany. RINGGOLD: 28342 FAU - Borte, Michael AU - Borte M AD - St. Georg Hospital Leipzig, Department of Pediatrics, Leipzig 04129, Germany. FAU - Krauss, Martin AU - Krauss M AUID- ORCID: 0000-0002-0362-4244 AD - Department of Exposure Science, Helmholtz Centre for Environmental Research-UFZ, Leipzig 04318, Germany. FAU - Brack, Werner AU - Brack W AD - Department of Exposure Science, Helmholtz Centre for Environmental Research-UFZ, Leipzig 04318, Germany. AD - Department of Evolutionary Ecology & Environmental Toxicology, Faculty of Biological Sciences-Goethe University Frankfurt, Frankfurt am Main, 60438, Germany. FAU - Zenclussen, Ana C AU - Zenclussen AC AD - Department of Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig 04318, Germany. RINGGOLD: 28342 AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden 04103, Germany. AD - Perinatal Immunology, Saxonian Incubator for Clinical Translation (SIKT), Medical Faculty, Leipzig University, Leipzig 04103, Germany. FAU - Herberth, Gunda AU - Herberth G AD - Department of Environmental Immunology, Helmholtz Centre for Environmental Research-UFZ, Leipzig 04318, Germany. RINGGOLD: 28342 AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Leipzig/Dresden 04103, Germany. FAU - Huber, Carolin AU - Huber C AUID- ORCID: 0000-0002-9355-8948 AD - Department of Exposure Science, Helmholtz Centre for Environmental Research-UFZ, Leipzig 04318, Germany. LA - eng PT - Journal Article DEP - 20251117 PL - United States TA - Environ Sci Technol Lett JT - Environmental science & technology letters JID - 101628367 PMC - PMC12879297 OTO - NOTNLM OT - asthma OT - eczema OT - pesticide metabolites OT - weighted quantile sum (WQS) regression OT - wheezing EDAT- 2026/02/09 12:54 MHDA- 2026/02/09 12:55 PMCR- 2026/02/06 CRDT- 2026/02/09 06:40 PHST- 2025/08/20 00:00 [received] PHST- 2025/11/10 00:00 [revised] PHST- 2025/11/12 00:00 [accepted] PHST- 2026/02/09 12:55 [medline] PHST- 2026/02/09 12:54 [pubmed] PHST- 2026/02/09 06:40 [entrez] PHST- 2026/02/06 00:00 [pmc-release] AID - 10.1021/acs.estlett.5c00836 [doi] PST - epublish SO - Environ Sci Technol Lett. 2025 Nov 17;12(12):1611-1617. doi: 10.1021/acs.estlett.5c00836. eCollection 2025 Dec 9. PMID- 41657810 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260209 LR - 20260211 IS - 2211-3355 (Print) IS - 2211-3355 (Electronic) IS - 2211-3355 (Linking) VI - 62 DP - 2026 Feb TI - Psychometric validation of the food and nutrition literacy scale (Escala de Literacia da Alimentacao e Nutricao - E-LAN) among Portuguese youth. PG - 103392 LID - 10.1016/j.pmedr.2026.103392 [doi] LID - 103392 AB - OBJECTIVES: Psychometric Validation of the Escala de Literacia da Alimentacao e Nutricao (E-LAN), addressing the current lack of validated instruments for assessing food and nutrition literacy among portuguese youth. STUDY DESIGN: Cross-sectional. METHODS: The study was conducted in a school setting in the western region of central Portugal between April 10 and 12, 2024, using a convenience sample of children aged 10-12 years. The E-LAN comprises 49 items (42 Likert-scale and 7 multiple-choice) across seven subscales assessing cognitive and skills domains. Reliability was examined using Cronbach's alpha, and confirmatory factor analysis (CFA) was performed to evaluate the internal structure, using chi(2)/df, AGFI, CFI, TLI, and RMSEA as fit indices. RESULTS: The initial scale showed good internal consistency (Cronbach's alpha = 0.875). Four items were removed due to low item-total correlations and factor loadings. The revised 38-item version demonstrated improved reliability (Cronbach's alpha = 0.889), acceptable inter-item correlations, and good model fit (chi(2)/df = 1.45; AGFI = 0.91; CFI = 0.93; TLI = 0.91; RMSEA = 0.06). CONCLUSIONS: The E-LAN is a concise, reliable, and valid tool for assessing food and nutrition literacy among portuguese youth, supporting its use in public health research and interventions. CI - (c) 2026 The Authors. Published by Elsevier Inc. FAU - Batalha, Maria Joao AU - Batalha MJ AD - ciTechCare - Center for Innovative Care and Health Technology, Polytechnic of Leiria, Portugal. AD - ENSP - Escola Nacional de Saude Publica - Universidade Nova de Lisboa, Portugal. FAU - Rosinha, Camila AU - Rosinha C AD - School of Health Sciences, Polytechnic of Leiria, Portugal. FAU - Amaro, Catarina AU - Amaro C AD - School of Health Sciences, Polytechnic of Leiria, Portugal. FAU - Couto, Mariana AU - Couto M AD - School of Health Sciences, Polytechnic of Leiria, Portugal. FAU - Fidalgo, Mariana AU - Fidalgo M AD - School of Health Sciences, Polytechnic of Leiria, Portugal. FAU - Dias, Sara Simoes AU - Dias SS AD - ciTechCare - Center for Innovative Care and Health Technology, Polytechnic of Leiria, Portugal. AD - School of Health Sciences, Polytechnic of Leiria, Portugal. LA - eng PT - Journal Article DEP - 20260127 PL - United States TA - Prev Med Rep JT - Preventive medicine reports JID - 101643766 PMC - PMC12877818 OTO - NOTNLM OT - E-LAN OT - Food literacy OT - Health promotion OT - Nutrition literacy OT - Portuguese youth OT - Psychometric validation COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/02/09 12:54 MHDA- 2026/02/09 12:55 PMCR- 2026/01/27 CRDT- 2026/02/09 06:39 PHST- 2025/09/10 00:00 [received] PHST- 2026/01/21 00:00 [revised] PHST- 2026/01/22 00:00 [accepted] PHST- 2026/02/09 12:55 [medline] PHST- 2026/02/09 12:54 [pubmed] PHST- 2026/02/09 06:39 [entrez] PHST- 2026/01/27 00:00 [pmc-release] AID - S2211-3355(26)00020-3 [pii] AID - 103392 [pii] AID - 10.1016/j.pmedr.2026.103392 [doi] PST - epublish SO - Prev Med Rep. 2026 Jan 27;62:103392. doi: 10.1016/j.pmedr.2026.103392. eCollection 2026 Feb. PMID- 41657688 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Direct and indirect effects of physical exercise on life satisfaction and quality of life in Chinese adolescents during the COVID-19 pandemic. PG - 1692392 LID - 10.3389/fpubh.2026.1692392 [doi] LID - 1692392 AB - BACKGROUND: The COVID-19 pandemic exacerbated mental health challenges among adolescents, yet the protective role of regular physical exercise (PE) in enhancing life satisfaction (LS) and quality of life (QOL) remains underexplored in this population. This study aimed to investigate the direct and indirect effects of PE on LS and QOL among Chinese adolescents during the pandemic, with a focus on its mediating pathways through alleviating depressive and anxious symptoms. METHODS: Adolescents aged 12 to 17 seeking for psychological services at Shandong Provincial Hospital were recruited between June 2021 and May 2022. Using the Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), 6-items QOL questionnaire (QOL-6), and Adolescent Students' Life Satisfaction Scale (ASLSS), we assessed depressive symptoms, anxious symptoms, QOL, and LS. RESULTS: A total of 392 adolescents (133 regular physical exercisers (PEs) vs. 259 non-regular physical exercisers (NPEs)) were included. Significant differences were observed in educational level, residence, general health status, and regular diet between PE and NPEs. A one-way ANOVA showed that PEs had significantly lower scores on GAD-7 and PHQ-9, higher QOL-6 scores, and greater LS across all six ASLSS dimensions compared to NPEs. The mediation analysis showed regular exercise indirect positive effects on QOL-6 and ASLSS 6 dimensions through the alleviation of anxious and depressive symptoms. Stepwise regression confirmed the significant positive effect of exercise on QOL, as well as LS with friendship, academic performance, and autonomy. CONCLUSION: PE alleviates emotional distress and enhances subjective well-being in adolescents through dual pathways, underscoring its value as a low-cost intervention during public health crises. Findings advocate integrating structured physical activity into school-based mental health programs to foster resilience. Longitudinal studies are needed to validate causal mechanisms and optimize exercise protocols for diverse adolescent populations. CI - Copyright (c) 2026 Dou, Ma, Qi, Ren, Zhao and Sun. FAU - Dou, Liqiang AU - Dou L AD - Department of Psychiatry, Qingdao University Medical College, Qingdao, China. AD - Department of Psychiatry, Pingdu Mental Health Center, Qingdao, China. FAU - Ma, Mi AU - Ma M AD - Department of Psychiatry, Qingdao University Medical College, Qingdao, China. AD - Department of Psychiatry, Qingdao Mental Health Center, Shandong, China. FAU - Qi, Wenbo AU - Qi W AD - Department of Psychiatry, Qingdao University Medical College, Qingdao, China. AD - Department of Psychiatry, Qingdao Mental Health Center, Shandong, China. FAU - Ren, Honghong AU - Ren H AD - Department of Psychology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. FAU - Zhao, Guoqing AU - Zhao G AD - Department of Psychology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China. FAU - Sun, Ping AU - Sun P AD - Department of Psychiatry, Qingdao University Medical College, Qingdao, China. AD - Department of Psychiatry, Qingdao Mental Health Center, Shandong, China. LA - eng PT - Journal Article DEP - 20260122 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Chinese people SB - IM MH - Humans MH - Adolescent MH - *Quality of Life/psychology MH - *COVID-19/epidemiology/psychology MH - *Exercise/psychology MH - Female MH - Male MH - China/epidemiology MH - *Personal Satisfaction MH - Depression/epidemiology MH - Anxiety/epidemiology MH - Child MH - Surveys and Questionnaires MH - Mental Health MH - East Asian People PMC - PMC12872919 OTO - NOTNLM OT - adolescents OT - anxious symptoms OT - depressive symptoms OT - life satisfaction OT - physical exercise OT - quality of life COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/09 12:54 MHDA- 2026/02/09 12:55 PMCR- 2026/01/22 CRDT- 2026/02/09 06:37 PHST- 2025/08/25 00:00 [received] PHST- 2025/12/19 00:00 [revised] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/02/09 12:55 [medline] PHST- 2026/02/09 12:54 [pubmed] PHST- 2026/02/09 06:37 [entrez] PHST- 2026/01/22 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1692392 [doi] PST - epublish SO - Front Public Health. 2026 Jan 22;14:1692392. doi: 10.3389/fpubh.2026.1692392. eCollection 2026. PMID- 41657451 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260209 LR - 20260211 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 15 IP - 1 DP - 2026 Jan 31 TI - Lactate dehydrogenase-to-albumin ratio as a predictor of coronary artery lesions in Kawasaki disease. PG - 11 LID - 10.21037/tp-2025-aw-704 [doi] LID - 11 AB - BACKGROUND: The lactate dehydrogenase-to-albumin ratio (LAR), a novel marker reflecting systemic inflammation and nutritional status, was investigated for its association with coronary artery lesions (CALs) in Kawasaki disease (KD). METHODS: A total of 231 pediatric patients with KD were stratified into the CAL group (n=35) and the non-CAL group (n=196). The CAL was defined based on the adjusted Z-score >/=2.0 of the coronary artery inner diameter according to body surface area. Demographic data and pre-treatment laboratory parameters were collected. Univariate analysis was used to screen for potential predictive factors, and multivariate logistic regression was used to analyze the influencing factors of KD complicated with CAL. The predictive performance was evaluated using the receiver operating characteristic (ROC) curve, and the area under the curve (AUC) was calculated. RESULTS: Univariate analysis revealed that the CAL group exhibited younger age, and significantly elevated levels of LAR and lactate dehydrogenase and higher proportion of incomplete KD compared to the non-CAL group (all P<0.05). Multivariate analysis confirmed LAR [odds ratio (OR) =1.152] and incomplete KD (OR =4.268) were independent predictive factors of CAL in KD. In the subgroup analysis of complete KD, LAR was remained significantly associated with CAL (P<0.05). ROC curve analysis identified the combined AUC of LAR and incomplete KD was 0.719 [95% confidence interval (CI): 0.629-0.810] and an optimal LAR cutoff of 6.97 (AUC =0.671, sensitivity =80.00%, specificity =53.10%). For complete KD, the optimal LAR cutoff for predicting CAL was 7.00, with an AUC of 0.662 (95% CI: 0.557-0.768). CONCLUSIONS: LAR was an independent influencing factor for KD complicated with CAL. LAR could be utilized as an auxiliary diagnostic biomarker for CAL in KD, particularly in complete KD cases, offering a reference for precise KD management. CI - (c) AME Publishing Company. FAU - Kong, Hui AU - Kong H AD - Department of Pediatrics, Second Affiliated Hospital of Anhui Medical University, Hefei, China. FAU - Tang, Zhen-Hai AU - Tang ZH AD - Center for Scientific Research of Anhui Medical University, Hefei, China. AD - Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Hefei, China. LA - eng PT - Journal Article DEP - 20260123 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC12877925 OTO - NOTNLM OT - Kawasaki disease (KD) OT - coronary artery lesions (CALs) OT - lactate dehydrogenase-to-albumin ratio (LAR) OT - predictive factors COIS- Conflicts of Interest: Both authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2025-aw-704/coif). The authors have no conflicts of interest to declare. EDAT- 2026/02/09 12:54 MHDA- 2026/02/09 12:55 PMCR- 2026/01/31 CRDT- 2026/02/09 06:35 PHST- 2025/10/11 00:00 [received] PHST- 2025/12/17 00:00 [accepted] PHST- 2026/02/09 12:55 [medline] PHST- 2026/02/09 12:54 [pubmed] PHST- 2026/02/09 06:35 [entrez] PHST- 2026/01/31 00:00 [pmc-release] AID - tp-15-01-11 [pii] AID - 10.21037/tp-2025-aw-704 [doi] PST - ppublish SO - Transl Pediatr. 2026 Jan 31;15(1):11. doi: 10.21037/tp-2025-aw-704. Epub 2026 Jan 23. PMID- 41657205 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 82 IP - 4 DP - 2026 Apr TI - Performance of large language models in answering frequently-asked questions on celiac disease. PG - 1072-1077 LID - 10.1002/jpn3.70375 [doi] AB - OBJECTIVES: Celiac disease (CeD) is a common autoimmune condition requiring lifelong adherence to a gluten-free diet (GFD). Patients and caregivers increasingly seek information online, and large language models (LLMs) have emerged as potential educational tools. However, their reliability in CeD remains uncertain. This study aimed to evaluate the performance of three popular LLMs in answering frequently asked questions (FAQs) about CeD and GFD management. METHODS: We conducted a cross-sectional comparative evaluation in which 12 FAQs were submitted to three LLMs: ChatGPT-4 (OpenAI), Gemini Flash 2.5 (Google), and Claude Sonnet 3.7 (Anthropic). Six pediatric gastroenterologists with expertise in CeD research and education, independently assessed and rated responses for accuracy, completeness, clarity, and overall quality using a 5-point Likert scale. RESULTS: The mean overall score across models was 4.3 +/- 0.35 out of 5. Clarity received the highest ratings (4.56 +/- 0.21), followed by accuracy (4.26 +/- 0.52), completeness (4.17 +/- 0.21), and overall quality (4.20 +/- 0.36). Responses to management-related questions scored significantly higher than those to diagnostic questions (4.4 vs. 4.2, p = 0.013). Inter-rater reliability was good (intraclass correlation coefficient = 0.74). Overall, Gemini achieved the highest ratings (p < 0.01). CONCLUSIONS: LLMs provide clear and generally accurate responses to CeD FAQs, particularly on management-related topics. While they represent a promising tool for patient education, variability in accuracy highlights the need for clinician oversight when interpreting artificial intelligence-generated medical information. CI - (c) 2026 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Peled, Nadav AU - Peled N AD - Adelson School of Medicine, Ariel University, Ariel, Israel. FAU - Shouval, Dror S AU - Shouval DS AD - Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petach Tikva, Israel. AD - Gray Faculty of Medical & Health Sciences, Tel-Aviv University, Tel Aviv, Israel. FAU - Gillett, Peter AU - Gillett P AD - Department of Child Life and Health, University of Edinburgh, Edinburgh, Scotland, UK. FAU - Szajewska, Hania AU - Szajewska H AD - Department of Paediatrics, The Medical University of Warsaw, Warsaw, Poland. FAU - Valitutti, Francesco AU - Valitutti F AD - Pediatrics Section, Department of Medicine and Surgery, University of Perugia, Perugia. FAU - Shamir, Raanan AU - Shamir R AD - Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petach Tikva, Israel. AD - Gray Faculty of Medical & Health Sciences, Tel-Aviv University, Tel Aviv, Israel. FAU - Guz-Mark, Anat AU - Guz-Mark A AUID- ORCID: 0000-0003-4175-7432 AD - Institute of Gastroenterology, Nutrition and Liver Diseases, Schneider Children's Medical Center of Israel, Petach Tikva, Israel. AD - Gray Faculty of Medical & Health Sciences, Tel-Aviv University, Tel Aviv, Israel. LA - eng GR - None/ PT - Comparative Study PT - Journal Article DEP - 20260209 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM MH - *Celiac Disease/diet therapy MH - Humans MH - *Large Language Models MH - Cross-Sectional Studies MH - Diet, Gluten-Free MH - Reproducibility of Results MH - *Patient Education as Topic/methods MH - Child PMC - PMC13050811 OTO - NOTNLM OT - artificial intelligence OT - coeliac disease OT - gluten-free diet OT - patient education COIS- The authors declare no conflicts of interest. EDAT- 2026/02/09 06:30 MHDA- 2026/04/06 00:31 PMCR- 2026/04/06 CRDT- 2026/02/09 05:03 PHST- 2025/12/10 00:00 [revised] PHST- 2025/10/03 00:00 [received] PHST- 2026/01/16 00:00 [accepted] PHST- 2026/04/06 00:31 [medline] PHST- 2026/02/09 06:30 [pubmed] PHST- 2026/02/09 05:03 [entrez] PHST- 2026/04/06 00:00 [pmc-release] AID - JPN370375 [pii] AID - 10.1002/jpn3.70375 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Apr;82(4):1072-1077. doi: 10.1002/jpn3.70375. Epub 2026 Feb 9. PMID- 41657119 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260819 IS - 1463-1326 (Electronic) IS - 1462-8902 (Print) IS - 1462-8902 (Linking) VI - 28 IP - 4 DP - 2026 Apr TI - Safety, feasibility, and dose-dependent metabolic effects of endoscopic duodenal pulsed electric field therapy in adults with type 2 diabetes: Results from two multicentre proof-of-concept studies. PG - 3367-3376 LID - 10.1111/dom.70533 [doi] AB - AIMS: The duodenum plays a central role in metabolic regulation, influencing insulin sensitivity, and glucose homeostasis. In type 2 diabetes (T2D), structural and functional abnormalities of the duodenal mucosa ("diabetic duodenopathy") are increasingly recognized as contributors to insulin resistance and dysglycaemia. Non-thermal duodenal cellular regeneration using pulsed electric field (PEF) therapy offers a novel approach to restore metabolic signalling and target the underlying pathophysiology of T2D. MATERIALS AND METHODS: An integrated analysis of two parallel, open-label, multicentre feasibility studies evaluated the safety, feasibility, and metabolic effects of PEF-based duodenal therapy in adults with uncontrolled T2D treated with non-insulin medications. Eligible participants (n = 71) were 18-70 years old, with body mass index 24-40 kg/m(2) and glycated haemoglobin (HbA1c) 7.5%-11.0% (58-97 mmol/mol). Participants underwent endoscopic, catheter-based PEF therapy to the duodenal wall (600 or 750 V, single or double application) and were followed for 48 weeks. The primary endpoint was the incidence of device- or procedure-related serious adverse events (SAEs). RESULTS: No device- or procedure-related SAEs were reported, demonstrating a favourable safety profile. Higher-energy dosing, double applications, and use of the second-generation catheter yielded greater and sustained metabolic improvements through 48 weeks, including reductions in HbA1c, fasting glucose, weight, and markers of insulin resistance. Continuous glucose monitoring showed sustained increases in time-in-range and reduced glycaemic variability. CONCLUSIONS: PEF-based duodenal regeneration therapy was safe, technically feasible, and associated with durable metabolic improvements over 48 weeks. These findings support further evaluation of duodenal electroporation as a novel, minimally invasive approach for managing T2D. CI - (c) 2026 The Author(s). Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd. FAU - O'Neal, David N AU - O'Neal DN AUID- ORCID: 0000-0002-0870-4032 AD - Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, Australia. AD - Department of Endocrinology and Diabetes, St Vincent's Hospital, Melbourne, Victoria, Australia. AD - Australian Centre for Accelerating Diabetes Innovations, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia. FAU - Sartoretto, Adrian AU - Sartoretto A AUID- ORCID: 0000-0002-7444-4822 AD - The BMI Clinic, Double Bay, New South Wales, Australia. FAU - Holt, Bronte A AU - Holt BA AD - Department of Gastroenterology, St Vincent's Hospital, Melbourne, Victoria, Australia. FAU - Abu Dayyeh, Barham K AU - Abu Dayyeh BK AD - Division of Gastroenterology and Hepatology, Cedars-Senai Medical Center, Los Angeles, California, USA. FAU - Vaughan, Rhys AU - Vaughan R AUID- ORCID: 0000-0002-4445-8000 AD - Department of Gastroenterology and Hepatology, Austin Health, Melbourne, Victoria, Australia. FAU - Cameron, Georgina AU - Cameron G AUID- ORCID: 0000-0002-5800-2450 AD - Department of Gastroenterology, St Vincent's Hospital, Melbourne, Victoria, Australia. FAU - Chandran, Sujievvan AU - Chandran S AUID- ORCID: 0000-0002-5015-6287 AD - Department of Gastroenterology and Hepatology, Austin Health, Melbourne, Victoria, Australia. FAU - Thompson, Alexander J AU - Thompson AJ AUID- ORCID: 0000-0001-9882-0071 AD - Department of Medicine, St Vincent's Hospital, University of Melbourne, Fitzroy, Victoria, Australia. AD - Department of Gastroenterology, St Vincent's Hospital, Melbourne, Victoria, Australia. FAU - McCollister, Howard AU - McCollister H AD - Minnesota Institute for Minimally Invasive Surgery, Crosby, Minnesota, USA. FAU - Severson, Paul AU - Severson P AD - Minnesota Institute for Minimally Invasive Surgery, Crosby, Minnesota, USA. FAU - Storm, Andrew C AU - Storm AC AD - Wake Forest University School of Medicine, Winston-Salelm, North Carolina, USA. FAU - Cunningham, Lian AU - Cunningham L AD - Endogenex, Plymouth, Minnesota, USA. FAU - Ekinci, Elif I AU - Ekinci EI AUID- ORCID: 0000-0003-2372-395X AD - Australian Centre for Accelerating Diabetes Innovations, Melbourne Medical School, The University of Melbourne, Melbourne, Victoria, Australia. LA - eng PT - Clinical Trial PT - Journal Article PT - Multicenter Study DEP - 20260209 PL - England TA - Diabetes Obes Metab JT - Diabetes, obesity & metabolism JID - 100883645 RN - 0 (Blood Glucose) RN - 0 (Glycated Hemoglobin) RN - 0 (hemoglobin A1c protein, human) SB - IM MH - Adolescent MH - Adult MH - Aged MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - Blood Glucose/metabolism MH - *Diabetes Mellitus, Type 2/therapy/metabolism/blood MH - *Duodenum/metabolism MH - *Electric Stimulation Therapy/methods/adverse effects MH - Feasibility Studies MH - Glycated Hemoglobin/metabolism MH - Insulin Resistance MH - Proof of Concept Study MH - Treatment Outcome PMC - PMC12992194 OTO - NOTNLM OT - continuous glucose monitoring (CGM) OT - duodenopathy OT - endoscopy OT - glycaemic control OT - pulsed electric field (PEF) OT - type 2 diabetes (T2D) COIS- BKAD reports research support from USGI Medical, Apollo Endosurgery, and Elektromedizin (ERBE); consulting relationships with Boston Scientific and Medtronic; and other relationships with Endogenex. AJT and ACS received research support from Endogenex. ACS additionally received support from Apollo Endosurgery, Boston Scientific, EndoTagss, Enterasense, OnePass, and SofTac, and serves as a consultant for Boston Scientific, Cook, EnVision, Olympus, Intuitive, Medtronic, Microtech, Sotelix, and Qaelon. LC is an employee of Endogenex. EDAT- 2026/02/09 06:29 MHDA- 2026/03/17 06:48 PMCR- 2026/03/17 CRDT- 2026/02/09 04:49 PHST- 2026/01/18 00:00 [revised] PHST- 2025/11/21 00:00 [received] PHST- 2026/01/25 00:00 [accepted] PHST- 2026/03/17 06:48 [medline] PHST- 2026/02/09 06:29 [pubmed] PHST- 2026/02/09 04:49 [entrez] PHST- 2026/03/17 00:00 [pmc-release] AID - DOM70533 [pii] AID - 10.1111/dom.70533 [doi] PST - ppublish SO - Diabetes Obes Metab. 2026 Apr;28(4):3367-3376. doi: 10.1111/dom.70533. Epub 2026 Feb 9. PMID- 41656733 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1941-2444 (Electronic) IS - 0148-6071 (Print) IS - 0148-6071 (Linking) VI - 50 IP - 4 DP - 2026 May TI - Performance of different nutrition risk screening tools in predicting malnutrition in critically ill children on mechanical ventilation: A comparison study. PG - 507-514 LID - 10.1002/jpen.70064 [doi] AB - BACKGROUND: This study aimed to characterize the distribution of nutrition status and nutrition risk stratification in critically ill children undergoing mechanical ventilation and to evaluate the association of nutrition risk with their clinical outcomes. METHODS: This comparison study included 375 critically ill children receiving mechanical ventilation (invasive or noninvasive, duration >/=24 h). Nutrition status at admission was evaluated using body mass index z score, and nutrition risk was assessed via three validated tools: Paediatric Yorkhill Malnutrition Score (PYMS), Screening Tool for the Assessment of Malnutrition in Pediatrics (STAMP), and Screening Tool for Risk on Nutritional Status and Growth (STRONGkids). Clinical data were extracted from electronic records. RESULTS: Three hundred seventy-five critically ill children undergoing mechanical ventilation were enrolled (207 boys, 168 girls; median age, 8 [2-26.5] months), with 246 receiving invasive and 129 noninvasive ventilation; 20.6% had moderate-severe malnutrition (59.7% in invasive ventilation). All tools identified >60% at high risk. STRONGkids (area under the curve [AUC], 0.90) and PYMS (AUC, 0.86) better predicted malnutrition than STAMP (AUC, 0.74). STRONGkids (AUC, 0.89) outperformed in mortality prediction. Higher risk correlated with longer ventilation/pediatric intensive care unit stay, higher costs, and worse outcomes (P < 0.05). Multivariate analysis showed malnutrition, clinical diagnosis, and lactate level as independent risk factors and no organ dysfunction, healthy serum prealbumin level, and healthy serum albumin level as protective factors. CONCLUSION: PYMS and STRONGkids demonstrated high predictive value for moderate-to-severe malnutrition and mortality in children undergoing mechanical ventilation. CI - (c) 2026 The Author(s). Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals LLC on behalf of American Society for Parenteral and Enteral Nutrition. FAU - Li, Ning AU - Li N AUID- ORCID: 0009-0002-9004-6354 AD - Department of Critical Care Medicine, Capital Institute of Pediatrics, Capital Center for Children's Health, Capital Medical University, Beijing, China. AD - Department of Critical Care Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Capital Center for Children's Health, Capital Medical University, Beijing, China. FAU - Chen, Jing AU - Chen J AD - Department of Critical Care Medicine, Capital Institute of Pediatrics, Capital Center for Children's Health, Capital Medical University, Beijing, China. FAU - Lu, Xiuxiu AU - Lu X AD - Department of Critical Care Medicine, Capital Institute of Pediatrics, Capital Center for Children's Health, Capital Medical University, Beijing, China. FAU - Li, Wei AU - Li W AD - Department of Critical Care Medicine, Capital Institute of Pediatrics, Capital Center for Children's Health, Capital Medical University, Beijing, China. FAU - Qu, Dong AU - Qu D AD - Department of Critical Care Medicine, Capital Institute of Pediatrics, Capital Center for Children's Health, Capital Medical University, Beijing, China. FAU - Liu, Shuang AU - Liu S AD - Department of Critical Care Medicine, Capital Institute of Pediatrics, Capital Center for Children's Health, Capital Medical University, Beijing, China. FAU - Wang, Lin AU - Wang L AD - Capital Institute of Pediatrics, Center of Children's Healthcare, Capital Center for Children's Health, Capital Medical University, Beijing, China. AD - Center of Children's Healthcare, Capital Center for Children's Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Capital Medical University, Beijing, China. LA - eng GR - 82273645/National Natural Science Foundation of China/ GR - L232121/Beijing Natural Science Foundation Haidian Original Innovation Joint Fund/ GR - 2024-1-1131/Capital's Funds for Health Improvement and Research/ GR - 7232235/Beijing Natural Science Foundation/ PT - Comparative Study PT - Journal Article DEP - 20260208 PL - United States TA - JPEN J Parenter Enteral Nutr JT - JPEN. Journal of parenteral and enteral nutrition JID - 7804134 SB - IM MH - Humans MH - *Respiration, Artificial/adverse effects MH - Female MH - *Critical Illness/therapy MH - Male MH - Child, Preschool MH - *Nutrition Assessment MH - *Malnutrition/diagnosis/etiology MH - Infant MH - *Nutritional Status MH - Risk Assessment/methods MH - Risk Factors MH - Body Mass Index MH - Length of Stay MH - Intensive Care Units, Pediatric MH - Area Under Curve PMC - PMC13169076 OTO - NOTNLM OT - children OT - critically ill OT - mechanical ventilation OT - nutrition risk OT - nutrition status COIS- None declared. EDAT- 2026/02/09 06:29 MHDA- 2026/05/13 12:32 PMCR- 2026/05/13 CRDT- 2026/02/09 01:34 PHST- 2026/01/17 00:00 [revised] PHST- 2025/04/09 00:00 [received] PHST- 2026/01/20 00:00 [accepted] PHST- 2026/05/13 12:32 [medline] PHST- 2026/02/09 06:29 [pubmed] PHST- 2026/02/09 01:34 [entrez] PHST- 2026/05/13 00:00 [pmc-release] AID - JPEN70064 [pii] AID - 10.1002/jpen.70064 [doi] PST - ppublish SO - JPEN J Parenter Enteral Nutr. 2026 May;50(4):507-514. doi: 10.1002/jpen.70064. Epub 2026 Feb 8. PMID- 41656457 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 1437-2320 (Electronic) IS - 0344-5607 (Print) IS - 0344-5607 (Linking) VI - 49 IP - 1 DP - 2026 Feb 9 TI - In-situ bone flap combined with a nasoseptal flap or a free mucosa flap for skull base reconstruction after endoscopic resection of craniopharyngiomas: A series of 115 cases. PG - 212 LID - 10.1007/s10143-025-04111-x [doi] LID - 212 AB - Previous reports have indicated that in comparison with the use of a nasal septal flap (NSF) for skull base reconstruction, the use of a free mucosal flap (FMF) is associated with an increased incidence of cerebrospinal fluid (CSF) leakage in patients with intraoperative high-flow CSF leakage but less nasal trauma. The authors previously reported that the use of an in situ bone flap (ISBF) was beneficial for controlling postoperative CSF leakage. The objective of this study was twofold. The first aim was to analyze the risk factors associated with postoperative CSF leakage. Second, the CSF leakage rate was compared between the two reconstruction techniques for different risk factors and total Sino-Nasal Outcome Test-20 (SNOT-20) scores. The results verify the feasibility of the use of an ISBF combined with an FMF for skull base reconstruction to control postoperative CSF leakage. Furthermore, the findings clarify the choice of skull base reconstruction in different situations. A retrospective review of 115 patients with craniopharyngiomas treated between May 2018 and June 2022 was conducted. Reconstruction of the skull base was performed in 67 patients using a combination of ISBF and NSF by October 2020 and in 48 patients using a combination of ISBF and FMF after October 2020. The overall rate of postoperative CSF leakage was 8.7%. According to the univariate analysis, a BMI >/= 25 (20.7% vs. 4.9%, p = 0.016) and predominantly solid tumors (15.1% vs. 3.2%, p = 0.042) were associated with higher rates of postoperative CSF leakage. In the multivariate analysis, a BMI >/= 25 and a solid component > 50% were identified as independent risk factors for postoperative CSF leakage. The mean SNOT-20 score was lower in the ISBF + FMF group than in the ISBF + NSF group at six months after surgery (13 +/- 12.7 vs. 16 +/- 16, p = 0.037). With respect to the repair of skull base defects by using the ISBF, the application of FMF controlled the postoperative CSF leakage rate within an acceptable range. Furthermore, it offered advantages over NSF in terms of SNOT-20 scores at six months post-operatively. A BMI >/= 25 and a solid component > 50% were independent risk factors for postoperative CSF leakage. NSF remains a more suitable option for patients with a BMI >/= 25. FAU - Mou, Jiamin AU - Mou J AD - Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, PR China. FAU - Wang, Xiaoshu AU - Wang X AD - Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, PR China. FAU - Yin, Qin AU - Yin Q AD - Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, PR China. FAU - Liu, Yi AU - Liu Y AD - Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, PR China. FAU - Lu, Hongfan AU - Lu H AD - Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, PR China. FAU - Sun, Xiaochuan AU - Sun X AD - Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, PR China. FAU - Yang, Gang AU - Yang G AD - Department of Neurosurgery, the First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, PR China. gangyang@hospital.cqmu.edu.cn. LA - eng GR - 2023MSXM071/Chongqing Municipal Public Health Bureau, Chongqing People's Municipal Government/ PT - Journal Article DEP - 20260209 PL - Germany TA - Neurosurg Rev JT - Neurosurgical review JID - 7908181 SB - IM MH - Humans MH - *Craniopharyngioma/surgery MH - Female MH - Male MH - *Plastic Surgery Procedures/methods MH - *Skull Base/surgery MH - Adult MH - Middle Aged MH - *Surgical Flaps MH - *Pituitary Neoplasms/surgery MH - Retrospective Studies MH - Cerebrospinal Fluid Leak MH - Adolescent MH - Postoperative Complications MH - Young Adult MH - Aged MH - *Nasal Septum/surgery MH - *Nasal Mucosa/transplantation MH - Risk Factors MH - Neuroendoscopy/methods PMC - PMC12883508 OTO - NOTNLM OT - Cerebrospinal fluid leakage. OT - Craniopharyngiomas OT - Extended endoscopic endonasal approaches OT - Free mucosa flap OT - In situ bone flap OT - Skull base reconstruction COIS- Declarations. Ethical approval: This retrospective study was approved by the Ethics Committee of the First Affiliated Hospital of Chongqing Medical University and informed consent was exempt (Approval Number: 2020 - 559). Consent to participate: Informed consent was not sought as a retrospective study design was used. Consent for publication: All data were anonymized, and the need for consent was waived by the ethics committee. Competing interests: The authors declare no competing interests. EDAT- 2026/02/09 00:29 MHDA- 2026/06/27 06:44 PMCR- 2026/02/09 CRDT- 2026/02/08 23:21 PHST- 2025/05/14 00:00 [received] PHST- 2025/12/27 00:00 [accepted] PHST- 2025/12/18 00:00 [revised] PHST- 2026/06/27 06:44 [medline] PHST- 2026/02/09 00:29 [pubmed] PHST- 2026/02/08 23:21 [entrez] PHST- 2026/02/09 00:00 [pmc-release] AID - 10.1007/s10143-025-04111-x [pii] AID - 4111 [pii] AID - 10.1007/s10143-025-04111-x [doi] PST - epublish SO - Neurosurg Rev. 2026 Feb 9;49(1):212. doi: 10.1007/s10143-025-04111-x. PMID- 41656342 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Feb 9 TI - Correlation of chronological, skeletal and dental (Demirjian method) ages in an Iranian growing orthodontic population - a cross-sectional study. LID - 10.1038/s41598-026-39319-4 [doi] LID - 7846 AB - Growth modification treatments are a type of orthodontic treatment used for patients who are still growing. The treatment plan and timing for these interventions are generally based on the chronological age of patients; however, achieving the most desirable outcome requires a thorough understanding of the physical development of children and adolescents. The aim of this study is to examine the correlation between chronological age and physical development in children and adolescents requiring orthodontic treatment. To assess physical development, both dental age and skeletal age were evaluated. Panoramic and lateral cephalometric radiographs of 194 orthodontic patients aged 7 to 17 years were randomly selected from a dental clinic in Gachsaran. Dental maturity was assessed using the Demirjian method, while skeletal maturity was evaluated using the cervical vertebral maturation stage (CVMS) method described by Baccetti. Data analysis was conducted using SPSS software version 27. The correlation between variables was calculated using Pearson's correlation coefficient and Spearman's rank correlation. The mean dental age of patients was found to be higher than their chronological age. Notably, the strongest correlation between dental age and chronological age for both males and females were observed at the first cervical vertebral maturation stage (CVMS1) highlighting its potential clinical relevance for early growth assessment. The positive Pearson correlation between dental age and chronological age was 0.894 in males and 0.876 in females. Moreover, a strong and significant positive correlation was found between dental age and skeletal age, with a Spearman's rank correlation coefficient of 0.779 in males and 0.785 in females. Additionally, a strong and significant positive correlation was observed between chronological age and skeletal age, with a Spearman's rank correlation coefficient of 0.783 in males and 0.707 in females. The results of this study indicate a significant positive correlation between chronological age and both methods of assessing physical development (dental age and skeletal age). The Demirjian method appears to overestimate dental age in the study population, suggesting a need to reassess its validity in Iranian population. Furthermore, the strongest correlation between chronological age and dental age was observed at the CVMS1 for both genders. These insights should be taken into account when planning growth modification treatments. FAU - Mohammadian-Rastani, Mehraneh AU - Mohammadian-Rastani M AD - Dentistry Student, School of Dentistry, Yasuj University of Medical Sciences, Yasuj, Iran. FAU - Gorjizadeh, Fatemeh AU - Gorjizadeh F AD - Department of Orthodontics, School of Dentistry, Yasuj University of Medical Sciences, Yasuj, Iran. Fatemegorjizade@gmail.com. FAU - Panahi, Seyedeh Roghayeh AU - Panahi SR AD - Department of Oral and Maxillofacial Radiology, School of Dentistry, Yasuj University of Medical Sciences, Yasuj, Iran. FAU - Mousavizadeh, Ali AU - Mousavizadeh A AD - Department of Biostatistics and Epidemiology, School of Health, Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran. LA - eng PT - Journal Article DEP - 20260209 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Child MH - Adolescent MH - Female MH - Iran MH - Male MH - Cross-Sectional Studies MH - *Age Determination by Teeth/methods MH - *Age Determination by Skeleton/methods MH - Cephalometry MH - Cervical Vertebrae/growth & development MH - Radiography, Panoramic MH - *Tooth/growth & development PMC - PMC12954074 OTO - NOTNLM OT - CVMS OT - Chronological age OT - Demirjian method OT - Dental maturity OT - Growth modification treatment OT - Skeletal maturity COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/02/09 00:29 MHDA- 2026/06/27 06:44 PMCR- 2026/02/09 CRDT- 2026/02/08 23:17 PHST- 2025/10/30 00:00 [received] PHST- 2026/02/04 00:00 [accepted] PHST- 2026/06/27 06:44 [medline] PHST- 2026/02/09 00:29 [pubmed] PHST- 2026/02/08 23:17 [entrez] PHST- 2026/02/09 00:00 [pmc-release] AID - 10.1038/s41598-026-39319-4 [pii] AID - 39319 [pii] AID - 10.1038/s41598-026-39319-4 [doi] PST - epublish SO - Sci Rep. 2026 Feb 9;16(1):7846. doi: 10.1038/s41598-026-39319-4. PMID- 41656337 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 45 IP - 1 DP - 2026 Feb 8 TI - From birth canal to classroom: a comparative analysis of academic performance among pupils born through vaginal and cesarean deliveries in Ogbomoso, Oyo State, Nigeria. LID - 10.1186/s41043-026-01256-3 [doi] LID - 91 AB - BACKGROUND: Many studies have investigated the relationship between vaginal and cesarean births and child developmental outcomes. However, evidence on whether mode of delivery influences long-term academic performance remains inconsistent, especially within Nigerian primary school populations. The present study assessed whether mode of delivery (vaginal vs. cesarean section) influences academic performance among primary school pupils in Ogbomoso, Oyo State, Nigeria. METHODS: This descriptive school-based cross-sectional study recruited 481 pupils using a multistage sampling technique. Data were collected using a structured, pretested questionnaire and validated academic records. Sociodemographic and perinatal variables were obtained from parents/guardians. Academic performance was calculated using weighted continuous assessments and end-of-term examinations. Statistical analysis was conducted using SPSS v26. Chi-square tests and multivariable logistic regression assessed associations, with significance set at 5%. RESULTS: The mean maternal age at delivery was 30.7 +/- 5.5 years. Overall mean academic score was 74.4 +/- 16.6, and 63.0% met the threshold for good performance. Vaginally delivered pupils recorded a higher proportion of good performance (67.6%) compared with cesarean-delivered pupils. However, after adjustment, maternal occupation, birth weight, and exclusive breastfeeding, but not mode of delivery, remained significant predictors of academic outcomes. Exclusive breastfeeding doubled the odds of good performance (AOR: 2.00; 95% CI: 1.18-3.38). CONCLUSION: Although vaginal delivery showed crude association with better performance, this effect disappeared after adjustment. Academic achievement was more strongly influenced by maternal education, birth weight, early childhood nutrition, and household socioeconomic conditions. Public health policies should strengthen maternal nutrition, breastfeeding promotion, perinatal care, and early learning support while ensuring safe delivery practices. FAU - Babatunde, Olaniyan Akintunde AU - Babatunde OA AD - Directorate of Public Health, Ministry of Health, Ibadan, Oyo State, Nigeria. tundebabson23@gmail.com. FAU - Ajetunmobi, Oluwaserimi Adewumi AU - Ajetunmobi OA AD - Department of Family Medicine, Afe Babalola University, Ado Ekiti, Ekiti State, Nigeria. AD - Oyo State Ministry of Health, State Secretariat, Agodi, Ibadan, Oyo State, Nigeria. FAU - Shittu, Saliu Ajedotun AU - Shittu SA AD - Education Commission for Foreign Medical Graduate, Waybread Lane, Rosenberg, TX, USA. FAU - Babawale, Victor AU - Babawale V AD - Division of Healthy Sexuality and Harm Reduction, Public Health Program, Winnipeg Regional Health Authority, Winnipeg, MB, Canada. FAU - Ibukun, Olatunbosun A AU - Ibukun OA AD - Public Health Emergency Preparedness Coordinator, Manitoba Health, Senior and Long-Term Care, Winnipeg, MB, Canada. FAU - Ayinde, Akintunde Kehinde AU - Ayinde AK AD - Oyo State Ministry of Health, State Secretariat, Agodi, Ibadan, Oyo State, Nigeria. FAU - Aremu, Adekunle AU - Aremu A AD - Directorate of Secondary Health Care and Training, Ministry of Health, Ibadan, Oyo State, Nigeria. FAU - Faleye, Joshua AU - Faleye J AD - Directorate of Health and Hospital Monitoring, Ministry of Health, Ibadan, Oyo State, Nigeria. FAU - Babalola, Olatunde Johnson AU - Babalola OJ AD - Directorate of Public Health, Ministry of Health, Ibadan, Oyo State, Nigeria. FAU - Akinyode, Akinfemi Adewumi AU - Akinyode AA AD - Directorate of Public Health, Ministry of Health, Ibadan, Oyo State, Nigeria. FAU - Kareem, Iyabode Abibaat AU - Kareem IA AD - Directorate of Public Health, Ministry of Health, Ibadan, Oyo State, Nigeria. FAU - Tolulope, Omodunbi AU - Tolulope O AD - National AIDS & STI Control Program, Abuja, Nigeria. FAU - Babatunde, Adekunbi Mofoyeke AU - Babatunde AM AD - Certified Information Systems Auditor (CISA), Information Systems Audit and Control Association (ISACA), Winnipeg, Canada. FAU - Dairo, Magbagbeola David AU - Dairo MD AD - Department of Epidemiology and Medical Statistics, Faculty of Public Health, College of Medicine, University of Ibadan, Ibadan, Nigeria. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260208 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Humans MH - Female MH - Nigeria MH - *Cesarean Section/statistics & numerical data MH - Cross-Sectional Studies MH - *Delivery, Obstetric/methods/statistics & numerical data MH - *Academic Performance/statistics & numerical data MH - Pregnancy MH - Adult MH - *Students/statistics & numerical data MH - Male MH - Child MH - Surveys and Questionnaires MH - Socioeconomic Factors MH - Schools PMC - PMC12983571 OTO - NOTNLM OT - Academic performance OT - Cesarean section, nigeria OT - Primary school pupils, cross-sectional study, mode of delivery OT - Vaginal delivery COIS- Declarations. Ethical approval and consent to participate: We obtained the approval for the study from the Ethical Review Committee, Oyo State Ministry of Health (No: AD13/479/2042), as well as concerned school authorities, to minimize interference during data collection. All the participants were made aware of the study and confidentiality measures. All the parents of participants provided their written informed consent and the participants provided their assent. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/09 00:29 MHDA- 2026/06/27 06:44 PMCR- 2026/02/08 CRDT- 2026/02/08 23:17 PHST- 2025/05/02 00:00 [received] PHST- 2026/01/24 00:00 [accepted] PHST- 2026/06/27 06:44 [medline] PHST- 2026/02/09 00:29 [pubmed] PHST- 2026/02/08 23:17 [entrez] PHST- 2026/02/08 00:00 [pmc-release] AID - 10.1186/s41043-026-01256-3 [pii] AID - 1256 [pii] AID - 10.1186/s41043-026-01256-3 [doi] PST - epublish SO - J Health Popul Nutr. 2026 Feb 8;45(1):91. doi: 10.1186/s41043-026-01256-3. PMID- 41656109 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1348-4540 (Electronic) IS - 0918-8959 (Print) IS - 0918-8959 (Linking) VI - 73 IP - 4 DP - 2026 Apr 1 TI - Age-dependent discordance in chemiluminescent immunoassay-electrochemiluminescence immunoassay correlation for 25-hydroxyvitamin D measurement reveals methodological considerations for assessment in early infancy. PG - 563-570 LID - 10.1507/endocrj.EJ25-0434 [doi] AB - Vitamin D (VD) status is assessed by measuring serum 25-hydroxyvitamin D (25(OH)D) levels using immunoassays. In December 2024, a Japanese diagnostic laboratory transitioned from chemiluminescent immunoassay (CLIA: LIAISON((R)) 25 OH Vitamin D Total Assay) to an electrochemiluminescent immunoassay (ECLIA: Elecsys((R)) Vitamin D Total III assay). Although these methods yield comparable results in adults, it remains unclear whether this applies to children, particularly newborns and infants. This study aims to clarify the impact of transition from CLIA to ECLIA on 25(OH)D levels during early infancy. Serum 25(OH)D levels were measured in 84 infants under three months old (67 under four days old) using both CLIA and ECLIA. Correlation and agreement were assessed using Passing-Bablok regression and Bland-Altman analyses, respectively. The obtained regression equation was applied to 252 age- and sex-matched cases from 2,253 historical controls in the registry to evaluate changes in VD classification. The regression equation was Y(ECLIA) = 0.846X(CLIA) - 2.281 (tau = 0.53, p < 0.001). Bland-Altman analysis revealed a constant negative bias of -4.89 +/- 3.53 ng/mL [-5.66, -4.12] (mean +/- standard deviation [95% confidence interval]) for ECLIA versus CLIA. Reclassification revealed an increase in VD deficiency (25(OH)D < 12 ng/mL) from 27.8% to 61.9%, and VD insufficiency (25(OH)D < 20 ng/mL) from 75.4% to 91.7%. The transition from CLIA to ECLIA led to lower measured 25(OH)D levels in newborns and infants and increased VD deficiency and insufficiency diagnoses. Method-specific differences should be considered when evaluating VD status during early infancy, particularly in infants under four days. FAU - Ota, Masashi AU - Ota M AUID- ORCID: 0009-0005-4075-0206 AD - Department of Pediatrics, Keio University School of Medicine, Tokyo 160-8582, Japan. FAU - Ikeda, Kazushige AU - Ikeda K AUID- ORCID: 0000-0002-3097-2156 AD - Division of Neonatology, Department of Pediatrics, Saitama City Hospital, Saitama 336-8522, Japan. FAU - Morisawa, Kazumi AU - Morisawa K AUID- ORCID: 0000-0002-9842-1596 AD - Department of Pediatrics, Keio University School of Medicine, Tokyo 160-8582, Japan. FAU - Nakagawa, Terumichi AU - Nakagawa T AUID- ORCID: 0000-0003-2177-506X AD - Clinical Laboratory, Keio University Hospital, Tokyo 160-8582, Japan. FAU - Hida, Mariko AU - Hida M AUID- ORCID: 0000-0003-3441-7755 AD - Division of Neonatology, Department of Pediatrics, Saitama City Hospital, Saitama 336-8522, Japan. FAU - Hara-Isono, Kaori AU - Hara-Isono K AUID- ORCID: 0000-0002-1311-8329 AD - Department of Pediatrics, Keio University School of Medicine, Tokyo 160-8582, Japan. LA - eng PT - Journal Article DEP - 20260207 PL - Japan TA - Endocr J JT - Endocrine journal JID - 9313485 RN - A288AR3C9H (25-hydroxyvitamin D) RN - 1406-16-2 (Vitamin D) SB - IM MH - Humans MH - *Vitamin D/analogs & derivatives/blood MH - Female MH - Immunoassay/methods MH - Infant MH - *Luminescent Measurements/methods MH - Male MH - Infant, Newborn MH - *Vitamin D Deficiency/diagnosis/blood MH - Age Factors MH - Electrochemical Techniques/methods PMC - PMC13066748 OTO - NOTNLM OT - 25-hydroxyvitamin D OT - Chemiluminescent immunoassay (CLIA) OT - Electrochemiluminescent immunoassay (ECLIA) OT - Infant OT - Vitamin D COIS- The authors have no conflict of interest. EDAT- 2026/02/09 00:29 MHDA- 2026/04/02 00:29 PMCR- 2026/02/07 CRDT- 2026/02/08 21:43 PHST- 2026/04/02 00:29 [medline] PHST- 2026/02/09 00:29 [pubmed] PHST- 2026/02/08 21:43 [entrez] PHST- 2026/02/07 00:00 [pmc-release] AID - 10.1507/endocrj.EJ25-0434 [doi] PST - ppublish SO - Endocr J. 2026 Apr 1;73(4):563-570. doi: 10.1507/endocrj.EJ25-0434. Epub 2026 Feb 7. PMID- 41654841 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260926 IS - 2662-7671 (Electronic) IS - 2662-7671 (Linking) VI - 26 IP - 1 DP - 2026 Feb 7 TI - Do traditional medicine-based diets lead to greater weight loss than modern diets in overweight and obese students? A randomized controlled trial. LID - 10.1186/s12906-026-05289-3 [doi] LID - 92 AB - BACKGROUND: Obesity in adolescents is a critical health concern linked to severe adulthood conditions; therefore, this randomized controlled trial compared the relative effectiveness of a modern dietary approach versus a traditional Iranian medicine-based diet for weight management. METHODS: Following simple randomization (stratified by gender and school type), 93 junior high school students were assigned to either a modern diet (300-500 kcal/day deficit, n = 41) or a traditional Iranian diet (qualitative humoral-based, n = 52) for 90 days. Dietary adherence was assessed using a 10-point Visual Analog Scale (VAS). Baseline demographic, anthropometric, and unhealthy eating pattern data were recorded. RESULTS: Over 90 days, the modern diet group achieved a statistically significant decrease in BMI (mean change: -0.31 kg/m(2); P = 0.032) and waist circumference (P < 0.001). Conversely, the traditional Iranian diet group showed a significant increase in weight and BMI (mean change: +0.74 kg/m(2); P < 0.001). Between-group differences for BMI change were highly significant favoring the modern diet (P < 0.001). Dietary adherence and feasibility scores improved in the modern group (P = 0.033) but decreased in the traditional group (P = 0.001). CONCLUSIONS: These findings suggest that the modern dietary approach was more effective for weight loss in this student population, likely due to better adherence influenced by greater public knowledge and accessibility of information, alongside healthier dietary pattern shifts. TRIAL REGISTRATION: The study is registered with the Iranian Registry of Clinical Trials (IRCT20230610058442N1 dated September 10, 2023). FAU - Farboud, Mohsen AU - Farboud M AUID- ORCID: 0000-0002-3659-8628 AD - Department of Public Health, School of Health, Fasa University of Medical Sciences, Fasa, Iran. FAU - Haghjoo, Elham AU - Haghjoo E AD - Department of Persian Medicine, Fasa University of Medical Sciences, Fasa, Iran. E_Haghjoo_56@yahoo.com. FAU - Naghizadeh, Mohammad Mehdi AU - Naghizadeh MM AD - Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran. FAU - Abolghasemi, Somayeh AU - Abolghasemi S AD - Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran. AD - Department of Nutrition, Fasa University of Medical Sciences, Fasa, Iran. FAU - Moradi, Maryam AU - Moradi M AD - Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran. AD - Department of Nutrition, Fasa University of Medical Sciences, Fasa, Iran. FAU - Zarepour, Fatemeh AU - Zarepour F AD - School of Public Health, Kerman University of Medical Sciences, Kerman, Iran. FAU - Heidarinejad, Fatemeh AU - Heidarinejad F AD - Department of Nutrition, Fasa University of Medical Sciences, Fasa, Iran. FAU - Ariya, Mohammad AU - Ariya M AUID- ORCID: 0000-0002-6732-1867 AD - Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran. ariya.mohammad1987@yahoo.com. AD - Department of Nutrition, Fasa University of Medical Sciences, Fasa, Iran. ariya.mohammad1987@yahoo.com. AD - School of Health Sciences, Western Sydney University, Campbelltown, Australia. ariya.mohammad1987@yahoo.com. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260207 PL - England TA - BMC Complement Med Ther JT - BMC complementary medicine and therapies JID - 101761232 SB - IM MH - Humans MH - Male MH - Adolescent MH - *Weight Loss MH - Female MH - Iran MH - *Overweight/diet therapy MH - *Obesity/diet therapy MH - Body Mass Index MH - Students PMC - PMC12977662 OTO - NOTNLM OT - Dietary interventions OT - Iranian traditional medicine OT - Modern diets OT - Obesity OT - Overweight OT - Students OT - Weight loss COIS- Declarations. Ethics approval and consent to participate: The study protocol followed the principles of the Helsinki Declaration and received approval from the Ethics Committee of Fasa University of Medical Sciences (Approval Code: IR.FUMS.REC.1402.064). All participants voluntarily took part after written informed consent was obtained from their parents or legal guardians and were informed of their right to withdraw at any time. They were assured that their data would remain confidential and would be used solely for research purposes, with results reported in aggregate form. The study was also registered with the Iranian Registry of Clinical Trials (IRCTID: IRCT20230610058442N1). The trial protocol and statistical analysis plan can be accessed at https://irct.behdasht.gov.ir/trial/71769 . Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/08 00:35 MHDA- 2026/06/28 00:36 PMCR- 2026/02/07 CRDT- 2026/02/07 23:26 PHST- 2025/07/16 00:00 [received] PHST- 2026/02/02 00:00 [accepted] PHST- 2026/06/28 00:36 [medline] PHST- 2026/02/08 00:35 [pubmed] PHST- 2026/02/07 23:26 [entrez] PHST- 2026/02/07 00:00 [pmc-release] AID - 10.1186/s12906-026-05289-3 [pii] AID - 5289 [pii] AID - 10.1186/s12906-026-05289-3 [doi] PST - epublish SO - BMC Complement Med Ther. 2026 Feb 7;26(1):92. doi: 10.1186/s12906-026-05289-3. PMID- 41654786 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Feb 7 TI - Improving the accuracy of fetal growth restriction diagnosis by integrating fetal genetic growth potential: a proof of concept study. LID - 10.1186/s12884-026-08785-z [doi] LID - 202 AB - BACKGROUND: Fetal growth restriction (FGR) is a common obstetric complication where a fetus fails to reach its genetically determined growth potential. Current diagnostic methods rely on population-based fetal biometric percentiles, which struggle to distinguish pathological FGR from healthy small-for-gestational-age (SGA) infants and may miss cases of growth restriction in fetuses with a high genetic growth potential who fall above conventional SGA thresholds. This study aimed to develop a novel diagnostic framework for FGR by incorporating individualized genetic potential modeling to improve precision in identification and risk stratification. METHODS: Using data from the Shanghai Birth Cohort (1,806 mother-infant pairs), fetal growth potential was calculated using a polygenic risk score for birth weight derived from fetal genome-wide association studies. A new metric, "FGR_degree," was developed as the difference between standardized genetic growth potential and actual birth weight Z-score. Fetuses were stratified into risk categories using a dual-threshold approach: the top 10% of FGR_degree values combined with SGA criteria (birth weight < 10th percentile). The high-risk "trueFGR" group included fetuses meeting both criteria. Maternal characteristics, pregnancy complications, neonatal outcomes, and neurodevelopmental outcomes at six months were analyzed using regression models. RESULTS: Among 1,806 mother-child pairs, 181 newborns were classified into the top 10% FGR_degree group, including 46 trueFGR cases. Compared to SGA infants, trueFGR infants exhibited consistent growth impairments: lower birth weight (2,599.7 g vs. 2,720.9 g, P = 0.02), reduced GROW centiles (4.8% vs. 5.7%, P < 0.001), and disproportionate body proportionality. NICU admission rates were higher in trueFGR (17.4% vs. 12.5%, P = 0.59). Neurodevelopmental outcomes showed a dose-response relationship between FGR_degree and 6-month deficits, with trueFGR conferring the highest adjusted risk for gross motor delay (OR 5.04, 95% CI [2.17, 11.69] vs. 3.51, 95% CI [1.85, 6.67] in SGA). Sensitivity analyses confirmed enhanced risk prediction by combining Top10_FGR_degree with SGA. CONCLUSIONS: Integrating fetal genomic data with birth weight enabled the development of a novel FGR severity metric. Combining FGR_degree with SGA classifications improved risk stratification, identifying high-risk fetuses more precisely. TrueFGR was associated with maternal complications, adverse outcomes, and neurodevelopmental delays at six months. Future research should explore non-invasive fetal DNA profiling and multi-ethnic validation. FAU - He, Xiaoqing AU - He X AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. AD - Department of Obstetrics, Center of Fetal Medicine & Intrauterine Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Jiang, Wen AU - Jiang W AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. FAU - Wang, Lei AU - Wang L AD - Department of Obstetrics, Center of Fetal Medicine & Intrauterine Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zeng, Xiaojing AU - Zeng X AD - Shanghai Key Laboratory of Embryo-originated Diseases, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China. FAU - Fang, Fang AU - Fang F AD - Department of Developmental and Behavioral Pediatrics and Child Primary Care, Brain and Behavioral Research Unit of Shanghai Institute for Pediatric Research, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Chen, Yan AU - Chen Y AD - Department of Neonatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Sun, Luming AU - Sun L AD - Department of Obstetrics, Center of Fetal Medicine & Intrauterine Pediatrics, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Huang, Yun AU - Huang Y AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. huangyun@shsmu.edu.cn. FAU - Zhang, Jun AU - Zhang J AD - Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, 1665 Kongjiang Road, Shanghai, 200092, China. junjimzhang@sjtu.edn.cn. AD - Shanghai Key Laboratory of Embryo-originated Diseases, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China. junjimzhang@sjtu.edn.cn. CN - Shanghai Birth Cohort LA - eng GR - 2022YFC2704700/National Key Research and Development Program of China/ GR - XKPF2024A100/Xinhua Hospital, affiliated with Shanghai Jiao Tong University School of Medicine/ GR - 82404277/National Natural Science Foundation of China/ GR - 24ZR1449200/Natural Science Foundation of Shanghai/ GR - 2020CXJQ01/Shanghai Municipal Health Commission/ PT - Journal Article DEP - 20260207 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - *Fetal Growth Retardation/diagnosis/genetics MH - Female MH - Pregnancy MH - Infant, Small for Gestational Age MH - Genetic Risk Score MH - Infant, Newborn MH - Birth Weight/genetics MH - *Fetal Development/genetics MH - Proof of Concept Study MH - Adult MH - China MH - Genome-Wide Association Study MH - Risk Assessment/methods PMC - PMC12930955 OTO - NOTNLM OT - Birth weight OT - Fetal growth restriction OT - Genetic potential OT - Polygenic risk score OT - Small-for-gestational-age. COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical principles of the Declaration of Helsinki.The study obtained ethical approval from the Institutional Review Boards of the Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (XHEC-C-2013-001-3). Written informed consent was obtained from the participants in this study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/08 00:35 MHDA- 2026/06/27 12:37 PMCR- 2026/02/07 CRDT- 2026/02/07 23:24 PHST- 2025/04/22 00:00 [received] PHST- 2026/02/04 00:00 [accepted] PHST- 2026/06/27 12:37 [medline] PHST- 2026/02/08 00:35 [pubmed] PHST- 2026/02/07 23:24 [entrez] PHST- 2026/02/07 00:00 [pmc-release] AID - 10.1186/s12884-026-08785-z [pii] AID - 8785 [pii] AID - 10.1186/s12884-026-08785-z [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Feb 7;26(1):202. doi: 10.1186/s12884-026-08785-z. PMID- 41653378 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20261009 IS - 1573-2649 (Electronic) IS - 0962-9343 (Linking) VI - 35 IP - 3 DP - 2026 Feb 7 TI - Psychometric properties comparison of EQ-5D-Y-3L and CHU9D in children and adolescents across different BMI classifications in Jiangsu, China. PG - 65 LID - 10.1007/s11136-026-04168-1 [doi] AB - BACKGROUND: This study aims to assess and compare the psychometric properties of EQ-5D-Y-3L and CHU9D in children and adolescents across different BMI classifications in Jiangsu, China. And to identify the more appropriate tool for BMI-related health related quality of life (HRQoL) assessment. METHODS: A multi-stage stratified random sampling approach was employed among children and adolescents aged 9 to 17 in Jiangsu Province. The feasibility, construct validity (including convergent, discriminant, and known-group validity) and ability to detect changes of these instruments were evaluated. Random forest models and restricted cubic spline analyses were utilized to examine factors associated with HRQoL. RESULTS: A survey of 37,574 participants (mean age: 13.53 years; 51.6% males) yielded complete data. The EQ-5D-Y-3L showed a higher ceiling effect (70.0%) than CHU9D (42.2%). Utility values for both instruments were highly correlated (r = 0.64), and the intraclass correlation coefficient (ICC) between the two utility values was 0.637. Moderate-to-high correlations were found in conceptually similar dimensions (r = 0.41-0.58, p < 0.001). Significant differences were observed in the two utility values and EQ-VAS across different BMI classifications (p < 0.001), with the CHU9D utility values and EQ-VAS demonstrating higher relative efficiency (RE > 1) and effect sizes (0.038-0.218) compared to EQ-5D-Y-3L utility values (0.044-0.104). Age, gender, BMI, boarding at school, and parents' education were significantly related to HRQoL (p < 0.05). CONCLUSIONS: Both EQ-5D-Y-3L and CHU9D show acceptable psychometric properties in Chinese children and adolescents, while utility values are not interchangeable. The CHU9D is recommended due to its superior ability to detecting changes and lower ceiling effect. Further study on the psychometric properties of EQ-VAS is needed. FAU - Liang, Junyan AU - Liang J AD - School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, China. AD - Chengdu Center for Disease Control and Prevention, Chengdu Institute of Health Supervision, 610041, Chengdu, China. FAU - Dong, Huibin AU - Dong H AD - Section of School Health, Changzhou Center for Disease Control and Prevention, Changzhou, 213022, China. FAU - Yang, Juan AU - Yang J AD - Section of School Health, Huai'an Center for Disease Control and Prevention, Huai'an, 223001, China. FAU - Xu, Xinpeng AU - Xu X AD - School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, China. FAU - Wu, Qifeng AU - Wu Q AD - School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, China. FAU - Gu, Minjia AU - Gu M AD - Nanjing Foreign Language School Xianlin Campus, Nanjing, 210003, China. FAU - Yi, Honggang AU - Yi H AD - School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, China. FAU - Liu, Li AU - Liu L AD - Section of School Health, Nanjing Center for Disease Control and Prevention, Nanjing, 210003, China. s042324l@126.com. FAU - You, Hua AU - You H AD - School of Public Health, Nanjing Medical University, 101 Longmian Avenue, Jiangning District, Nanjing, 211166, China. youhua98@163.com. AD - Laboratory for Digital Intelligence and Health Governance, Nanjing Medical University, Nanjing, 211166, China. youhua98@163.com. LA - eng GR - QY202408/Science and Technology Project of Changzhou municipal health commission/ GR - 72074122/the National Natural Science Foundation of China/ PT - Comparative Study PT - Journal Article DEP - 20260207 PL - Netherlands TA - Qual Life Res JT - Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation JID - 9210257 SB - IM MH - Humans MH - *Psychometrics MH - Adolescent MH - Female MH - Child MH - Male MH - *Quality of Life/psychology MH - China MH - *Body Mass Index MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Health Status OTO - NOTNLM OT - Body mass index OT - CHU9D OT - China OT - EQ-5D-Y-3L OT - Health-related quality of life OT - Psychometric property OT - Reliability OT - Validity COIS- Declarations. Competing interests: The authors declare that they have no competing interests. Ethics approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Ethical Review Committee of Nanjing Medical University (Ethics approval number: ((2021) 661). Consent to participate: Verbal informed consent was obtained from all individual participants and their legal guardians. Consent for publication: The authors affirm that human research participants provided informed consent for publication of the information in all tables and figures. EDAT- 2026/02/07 12:52 MHDA- 2026/06/27 18:37 CRDT- 2026/02/07 11:16 PHST- 2025/10/21 00:00 [received] PHST- 2026/01/07 00:00 [accepted] PHST- 2026/06/27 18:37 [medline] PHST- 2026/02/07 12:52 [pubmed] PHST- 2026/02/07 11:16 [entrez] AID - 10.1007/s11136-026-04168-1 [pii] AID - 10.1007/s11136-026-04168-1 [doi] PST - epublish SO - Qual Life Res. 2026 Feb 7;35(3):65. doi: 10.1007/s11136-026-04168-1. PMID- 41653171 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1097-6752 (Electronic) IS - 0889-5406 (Linking) VI - 169 IP - 5 DP - 2026 May TI - Prediction of skeletal maturity using machine learning based on multiple biological indicators. PG - 629-639.e1 LID - S0889-5406(26)00009-0 [pii] LID - 10.1016/j.ajodo.2025.11.020 [doi] AB - INTRODUCTION: Accurate assessment of skeletal maturity is essential for orthodontic treatment planning and growth modulation. This study aimed to develop a comprehensive machine learning (ML) model to predict skeletal maturation stages using cervical vertebral morphology, dental maturation stage (DMS), gender, and age. METHODS: A total of 860 patients with lateral cephalograms, panoramic, and hand-wrist radiographs were included. A baseline model using 6 cervical morphologic parameters was compared with enhanced models incorporating DMS, gender, and age. Six ML algorithms were evaluated, with CatBoost showing the highest performance. Feature importance was analyzed using 2 methods, and the final model was assessed using a confusion matrix, receiver operating characteristic curves, and calibration curves. RESULTS: Incorporating DMS, gender, and age significantly improved predictive performance. The CatBoost model achieved an area under the receiver operating characteristic curve of 0.924, an area under the precision-recall curve of 0.806, and an F1-score of 0.752. Feature importance analysis confirmed the strong predictive contribution of DMS, especially the mandibular second molar. The final model demonstrated high accuracy, strong discrimination, and good calibration across all skeletal maturity stages. CONCLUSIONS: This study presents a novel and clinically practical ML model for skeletal maturity prediction, integrating routinely acquired orthodontic records. The results demonstrate that combining DMS with cervical morphology, age, and gender enhances prediction accuracy, offering a reliable alternative to traditional hand-wrist assessments. CI - Copyright (c) 2026 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved. FAU - Guo, Man AU - Guo M AD - Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China. FAU - Daraqel, Baraa AU - Daraqel B AD - Department of Orthodontics, Oral Health Research and Promotion Unit, Al-Quds University, Jerusalem, Palestine. FAU - Ai, Dongqing AU - Ai D AD - Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China. FAU - Ma, Xinjun AU - Ma X AD - School of Computer Science and Technology, Chongqing University of Posts and Telecommunications, Chongqing, China. FAU - Dong, Yihan AU - Dong Y AD - Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China. FAU - Hu, Yun AU - Hu Y AD - Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China. Electronic address: 500188@hospital.cqmu.edu.cn. FAU - Zheng, Leilei AU - Zheng L AD - Chongqing Key Laboratory of Oral Diseases, Chongqing Municipal Health Commission Key Laboratory of Oral Biomedical Engineering, Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, The Affiliated Stomatological Hospital of Chongqing Medical University, Chongqing, China. Electronic address: zhengleileicqmu@hospital.cqmu.edu.cn. LA - eng PT - Journal Article DEP - 20260207 PL - United States TA - Am J Orthod Dentofacial Orthop JT - American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics JID - 8610224 SB - IM MH - Humans MH - Female MH - *Age Determination by Skeleton/methods MH - *Machine Learning MH - Cephalometry MH - Male MH - *Cervical Vertebrae/growth & development/diagnostic imaging MH - Predictive Learning Models MH - Boosting Machine Learning Algorithms MH - Adolescent MH - Child MH - Prediction Algorithms MH - Radiography, Panoramic MH - Classification Algorithms MH - Age Factors MH - ROC Curve EDAT- 2026/02/07 12:53 MHDA- 2026/04/23 00:31 CRDT- 2026/02/07 10:27 PHST- 2025/06/01 00:00 [received] PHST- 2025/11/01 00:00 [revised] PHST- 2025/11/01 00:00 [accepted] PHST- 2026/04/23 00:31 [medline] PHST- 2026/02/07 12:53 [pubmed] PHST- 2026/02/07 10:27 [entrez] AID - S0889-5406(26)00009-0 [pii] AID - 10.1016/j.ajodo.2025.11.020 [doi] PST - ppublish SO - Am J Orthod Dentofacial Orthop. 2026 May;169(5):629-639.e1. doi: 10.1016/j.ajodo.2025.11.020. Epub 2026 Feb 7. PMID- 41652667 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1098-108X (Electronic) IS - 0276-3478 (Print) IS - 0276-3478 (Linking) VI - 59 IP - 5 DP - 2026 May TI - Multivariate Trajectories of Eating Disorder Symptoms and Weight Status in 10- to 17-Year-Old Children and Adolescents. PG - 978-995 LID - 10.1002/eat.70045 [doi] AB - OBJECTIVE: Eating disorders (EDs) often emerge in adolescence, but developmental trajectories across different core features remain largely unclear. METHOD: The prospective, community-based study included N = 898 participants aged 9.5-17.5 years (47.6% female, age 11.8 +/- 1.4 years) with annual follow-up over 2-6 (3.4 +/- 1.2) years. Multivariate trajectories of binge eating, restraint, weight-compensatory behaviors (Eating Disorder Examination-Questionnaire for Children), and body mass index-standard deviation score (BMI-SDS) derived from objective anthropometrics were analyzed using group-based multi-trajectory modeling (GBMTM) separately for girls and boys. ED and general psychopathology were used for validation and outcome comparisons. RESULTS: GBMTM identified five distinct trajectories of ED symptoms and BMI-SDS in girls and six in boys. Low-symptom trajectories at lower, normal, and higher BMI-SDS were most common and showed only mild, transient ED symptoms. In boys, trajectories were largely characterized by stable ED symptoms at different BMI-SDS levels, whereas in girls, ED symptoms showed more pronounced change over time. In both sexes, two high-risk subgroups reflected bulimic and binge-eating patterns and followed trajectories with elevated or increasing ED symptoms across ages, which in girls were particularly associated with increased ED and general psychopathology at last assessment. DISCUSSION: GBMTM results support the developmental specificity of bulimic/binge-eating syndromes and noneating-disordered overweight across adolescence. High-risk subgroups in both sexes-and their particularly unfavorable outcomes in girls-underscore the need for sex-specific early identification strategies that consider longitudinal constellations of multiple ED symptoms and weight status rather than single indicators. CI - (c) 2026 The Author(s). International Journal of Eating Disorders published by Wiley Periodicals LLC. FAU - Hilbert, Anja AU - Hilbert A AUID- ORCID: 0000-0003-2775-1296 AD - Integrated Research and Treatment Center AdiposityDiseases, Behavioral Medicine Research Unit, Department of Psychosomatic Medicine and Psychotherapy, Leipzig University Medical Center, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), partner site Leipzig/Dresden, Leipzig, Germany. FAU - Schewe, Danielle AU - Schewe D AUID- ORCID: 0009-0006-7237-1945 AD - Integrated Research and Treatment Center AdiposityDiseases, Behavioral Medicine Research Unit, Department of Psychosomatic Medicine and Psychotherapy, Leipzig University Medical Center, Leipzig, Germany. FAU - Hiemisch, Andreas AU - Hiemisch A AUID- ORCID: 0000-0001-6851-1307 AD - LIFE Leipzig Research Center for Civilization Diseases, Leipzig University, Leipzig, Germany. AD - Department of Women and Child Health, University Hospital for Children and Adolescents and Center for Pediatric Research, Leipzig University, Leipzig, Germany. FAU - Korner, Antje AU - Korner A AUID- ORCID: 0000-0001-6001-0356 AD - German Center for Child and Adolescent Health (DZKJ), partner site Leipzig/Dresden, Leipzig, Germany. AD - LIFE Leipzig Research Center for Civilization Diseases, Leipzig University, Leipzig, Germany. AD - Department of Women and Child Health, University Hospital for Children and Adolescents and Center for Pediatric Research, Leipzig University, Leipzig, Germany. FAU - Kiess, Wieland AU - Kiess W AUID- ORCID: 0000-0003-4118-9455 AD - German Center for Child and Adolescent Health (DZKJ), partner site Leipzig/Dresden, Leipzig, Germany. AD - LIFE Leipzig Research Center for Civilization Diseases, Leipzig University, Leipzig, Germany. AD - Department of Women and Child Health, University Hospital for Children and Adolescents and Center for Pediatric Research, Leipzig University, Leipzig, Germany. FAU - Schmidt, Ricarda AU - Schmidt R AUID- ORCID: 0000-0001-7794-2897 AD - Integrated Research and Treatment Center AdiposityDiseases, Behavioral Medicine Research Unit, Department of Psychosomatic Medicine and Psychotherapy, Leipzig University Medical Center, Leipzig, Germany. AD - German Center for Child and Adolescent Health (DZKJ), partner site Leipzig/Dresden, Leipzig, Germany. LA - eng GR - Leipzig Research Center for Civilization Diseases (LIFE)/ GR - Leipzig University/ GR - European Union/ GR - European Social Fund/ GR - European Regional Development Fund/ GR - Freistaat Sachsen/ PT - Journal Article DEP - 20260206 PL - United States TA - Int J Eat Disord JT - The International journal of eating disorders JID - 8111226 SB - IM MH - Humans MH - Child MH - Female MH - *Feeding and Eating Disorders/psychology/diagnosis MH - Adolescent MH - Male MH - Body Mass Index MH - Prospective Studies MH - *Body Weight PMC - PMC13147146 OTO - NOTNLM OT - binge eating OT - body mass index OT - compensatory behavior OT - development OT - eating disorder OT - latent structure analysis OT - obesity OT - restraint OT - trajectory COIS- During the preparation of this work the authors used ChatGPT (OpenAI, version 5.0 and 5.1) and DeepL (DeepL SE) in order to improve the readability and language of the manuscript. After using this tool, the authors reviewed and edited the content as needed and took full responsibility for the content of the published article. Dr. Hilbert reports receiving research grants from the German Federal Ministry of Education and Research, German Research Foundation, Innovation Fund, and Roland Ernst Foundation for Health Care; royalties for books on the treatment of eating disorders and obesity with Hogrefe and Kohlhammer; honoraria for workshops and lectures on eating disorders and obesity and their treatment, including from Lilly, Novo Nordisk, and Rhythm Pharmaceuticals; honoraria as editor of the International Journal of Eating Disorders; and honoraria as a consultant for Takeda and Medice. No other conflicts of interest were reported. EDAT- 2026/02/07 06:33 MHDA- 2026/05/06 06:39 PMCR- 2026/05/06 CRDT- 2026/02/07 00:53 PHST- 2026/01/19 00:00 [revised] PHST- 2025/07/24 00:00 [received] PHST- 2026/01/21 00:00 [accepted] PHST- 2026/05/06 06:39 [medline] PHST- 2026/02/07 06:33 [pubmed] PHST- 2026/02/07 00:53 [entrez] PHST- 2026/05/06 00:00 [pmc-release] AID - EAT70045 [pii] AID - 10.1002/eat.70045 [doi] PST - ppublish SO - Int J Eat Disord. 2026 May;59(5):978-995. doi: 10.1002/eat.70045. Epub 2026 Feb 6. PMID- 41652603 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260314 LR - 20260813 IS - 2055-5784 (Print) IS - 2055-5784 (Electronic) IS - 2055-5784 (Linking) VI - 12 IP - 1 DP - 2026 Feb 6 TI - SmartAPPetite For Youth: pilot and feasibility study of an adolescent smartphone nutrition intervention. LID - 10.1186/s40814-026-01767-0 [doi] LID - 39 AB - BACKGROUND: Canadian adolescents report poor dietary quality. Smartphone-based nutrition interventions have the potential to improve adolescent diets through food knowledge and purchasing. "SmartAPPetite for Youth" is a smartphone-based nutrition intervention for adolescents that addresses key gaps in the literature. The study objective is to evaluate the intervention for feasibility, acceptability, and usability before undertaking a full-scale randomized controlled study. METHODS: The study was conducted in March-June 2016, among adolescents aged 14 years attending a secondary school in London, Ontario. Participants received the SmartAPPetite application on their phones, which sent time-based healthy eating messages (max 3/day) and location-based "nudge" messages (max 5/day) for 8 weeks. To evaluate recruitment methods, performance of app features, suitability of study instruments, and overall feasibility (measured by the rate of study retention, with a target of 70%), data was collected via the following: (1) a pre-post youth survey; (2) assessing participant experience; and (3) researcher observations. The youth survey included demographic questions, and questions about nutrition perceptions, food intake behaviors, food knowledge, and food purchasing behaviors. Questions about participant experiences included how often they interacted with the app, what they liked, and what they thought should be improved. RESULTS: Of 108 eligible adolescents, 59 consented to participate and 54 completed the follow-up survey. Most participants reported that the app benefitted them and stated that they would recommend the app to a friend. Results from the youth survey show that SmartAPPetite has the potential to influence food knowledge, food purchasing, and food intake behaviors. The implementation review identified some changes to our intervention study design, tools, and the app that are required for it to have the greatest impact in a scaled-up scientifically rigorous randomized controlled study. CONCLUSIONS: The results of this pilot study show that the project is feasible, and that adolescents will accept the intervention and enjoy engaging with the app. The app was well accepted, and participants perceived that it was helpful in improving their food knowledge and health behaviors. The primary objective of this study identified some key lessons that can be built upon for a larger study. The impact of the app needs to be properly tested in a full-scale trial. CI - (c) 2026. The Author(s). FAU - Gilliland, J AU - Gilliland J AD - Human Environments Analysis Laboratory, Western University, London, ON, Canada. jgillila@uwo.ca. AD - Children's Health Research Institute, London, ON, Canada. jgillila@uwo.ca. AD - Department of Geography, Western University, London, ON, Canada. jgillila@uwo.ca. AD - Department of Pediatrics, Western University, London, ON, Canada. jgillila@uwo.ca. AD - School of Health Studies, Western University, London, ON, Canada. jgillila@uwo.ca. AD - Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. jgillila@uwo.ca. AD - Lawson Health Research Institute, London, ON, Canada. jgillila@uwo.ca. FAU - Bowman, D AU - Bowman D AD - Human Environments Analysis Laboratory, Western University, London, ON, Canada. AD - Department of Geography, Western University, London, ON, Canada. FAU - Cappuccitti, S AU - Cappuccitti S AD - Human Environments Analysis Laboratory, Western University, London, ON, Canada. AD - Department of Geography, Western University, London, ON, Canada. FAU - Caruso, O AU - Caruso O AD - Human Environments Analysis Laboratory, Western University, London, ON, Canada. AD - Children's Health Research Institute, London, ON, Canada. AD - Department of Geography, Western University, London, ON, Canada. FAU - Clark, A AU - Clark A AD - Human Environments Analysis Laboratory, Western University, London, ON, Canada. AD - Department of Geography, Western University, London, ON, Canada. FAU - Doherty, S AU - Doherty S AD - Wilfrid Laurier University, Waterloo, ON, Canada. FAU - Haines, J AU - Haines J AD - University of Guelph, Guelph, ON, Canada. FAU - McEachern, L W AU - McEachern LW AD - Human Environments Analysis Laboratory, Western University, London, ON, Canada. AD - Children's Health Research Institute, London, ON, Canada. AD - Department of Geography, Western University, London, ON, Canada. FAU - Minaker, L AU - Minaker L AD - University of Waterloo, Waterloo, ON, Canada. FAU - O'Connor, C AU - O'Connor C AD - Human Environments Analysis Laboratory, Western University, London, ON, Canada. AD - Brescia School of Food and Nutritional Sciences, Western University, London, ON, Canada. FAU - Sadler, R C AU - Sadler RC AD - Human Environments Analysis Laboratory, Western University, London, ON, Canada. AD - Department of Public Health, Michigan State University, Flint, MI, USA. FAU - Schaafsma, H AU - Schaafsma H AD - Human Environments Analysis Laboratory, Western University, London, ON, Canada. AD - Children's Health Research Institute, London, ON, Canada. AD - School of Health Studies, Western University, London, ON, Canada. FAU - Seabrook, J AU - Seabrook J AD - Human Environments Analysis Laboratory, Western University, London, ON, Canada. AD - Children's Health Research Institute, London, ON, Canada. AD - Department of Pediatrics, Western University, London, ON, Canada. AD - Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. AD - Lawson Health Research Institute, London, ON, Canada. AD - Brescia School of Food and Nutritional Sciences, Western University, London, ON, Canada. FAU - Stranges, S AU - Stranges S AD - Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. FAU - Tobin, D AU - Tobin D AD - Human Environments Analysis Laboratory, Western University, London, ON, Canada. FAU - Woods, N AU - Woods N AD - Human Environments Analysis Laboratory, Western University, London, ON, Canada. AD - School of Health Studies, Western University, London, ON, Canada. FAU - Wray, A J AU - Wray AJ AD - Human Environments Analysis Laboratory, Western University, London, ON, Canada. AD - Children's Health Research Institute, London, ON, Canada. AD - Department of Geography, Western University, London, ON, Canada. FAU - Zhong, S AU - Zhong S AD - Human Environments Analysis Laboratory, Western University, London, ON, Canada. AD - Children's Health Research Institute, London, ON, Canada. AD - Department of Geography, Western University, London, ON, Canada. LA - eng GR - G-17-0018327/Heart and Stroke Foundation of Canada/ GR - 2015-17/Children's Health Foundation/ GR - 399384/CAPMC/CIHR/Canada GR - 399384/CAPMC/CIHR/Canada PT - Journal Article DEP - 20260206 PL - England TA - Pilot Feasibility Stud JT - Pilot and feasibility studies JID - 101676536 PMC - PMC12983698 OTO - NOTNLM OT - Adolescent OT - Diet quality OT - Food environments OT - Food knowledge OT - Nutrition intervention OT - Smartphone app COIS- Declarations. Ethics approval and consent to participate: The SmartAPPetite for Youth pilot and feasibility study was approved by Western University's Non-Medical Research Ethics Board (REB#:107034) and the local school board ethics committee. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/02/07 06:33 MHDA- 2026/02/07 06:34 PMCR- 2026/02/06 CRDT- 2026/02/07 00:10 PHST- 2025/06/25 00:00 [received] PHST- 2026/01/13 00:00 [accepted] PHST- 2026/02/07 06:34 [medline] PHST- 2026/02/07 06:33 [pubmed] PHST- 2026/02/07 00:10 [entrez] PHST- 2026/02/06 00:00 [pmc-release] AID - 10.1186/s40814-026-01767-0 [pii] AID - 1767 [pii] AID - 10.1186/s40814-026-01767-0 [doi] PST - epublish SO - Pilot Feasibility Stud. 2026 Feb 6;12(1):39. doi: 10.1186/s40814-026-01767-0. PMID- 41652582 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Feb 6 TI - Small intestinal microbiota of undernourished women of reproductive age and microbiota-directed balanced energy protein (MD-BEP) supplementation in maternal environmental enteric dysfunction (EED): protocol for a community-based intervention study. LID - 10.1186/s12884-026-08710-4 [doi] LID - 248 AB - INTRODUCTION: Studies show, malnourished women of childbearing age with environmental enteric dysfunction (EED) exhibit small intestinal enteropathy resembling that in malnourished children residing in the same community. However, currently there are no universally accepted protocols for validation of these facts. Our current protocol is designed to better understand the mechanism of transmission of the microbiota of mothers with EED to their children perpetuates intergenerational undernutrition. We plan to compare the small intestinal (SI) and fecal microbiota along with plasma, duodenal, and fecal proteomes/ metabolomes and histopathologic evidence of EED in non-pregnant women with and without malnutrition. We also plan to see and compare the effect of microbiota-directed balanced energy protein (MD-BEP) supplementation on these biological parameters between malnourished non-pregnant and pregnant women. METHODS AND ANALYSIS: This is a community-based intervention study where pregnant women and non-pregnant women of reproductive age (18-35 years) will be screened through household surveys from the Bauniabadh and adjacent slum area of Mirpur, Dhaka (pregnant and non-pregnant cohorts, n=90 each). Using Body Mass Index (BMI), both the groups will be categorized into undernourished (BMI <18.5kg/m2, n=60 each with pregnant and non-pregnant cohort) and well-nourished (BMI >20-24.9 kg/ m2, n=30, each with pregnant and non-pregnant cohort). Upper gastro-intestinal (UGI) endoscopy will be performed on non-pregnant women (both well-nourished and undernourished cohorts) and biopsy samples will be collected for diagnosis of environmental enteric dysfunction (EED) by histopathological scoring. We will compare the small intestinal (SI) and fecal microbiota and the plasma, duodenal, and fecal proteomes/ metabolomes of the undernourished non-pregnant cohort with histopathologic evidence of EED with the well-nourished non-pregnant cohort with no histopathologic evidence of EED (Aim IA). Furthermore, we will perform an intervention study (Aim IB). The undernourished non-pregnant cohort will be randomized into two groups (n=30/arm) and receive daily dietary supplementation with either shelf-stable microbiota-directed balanced energy protein (MD-BEP) or ready-to -use supplementary food balanced energy protein (RUSF-BEP) for 90 days. After cessation of the intervention they will be further followed up for another 270 days and biological samples will be collected at scheduled time points. The well-nourished non-pregnant cohort will not receive any nutritional intervention will serve as a reference control group. The undernourished pregnant cohort will also be randomly (n=30/arm) assigned to receive either MD-BEP or RUSF-BEP daily for 6 months until the child birth and thereafter for 3 months and followed up for another 9 months. During this period anthropometry will be measured and biological samples including fecal and plasma samples will be collected from the mothers and their infants in scheduled time points. Anthropometric, socio-demographic and laboratory assay data will be compared between the groups and candidate EED biomarkers will be correlated with nutritional status, histological analyses and score of EED, plus assessments of microbial community structure will be examined. ETHICS AND DISSEMINATION: Ethics approval was obtained from the Ethical Review Committee of icddr,b (protocol no: PR-22117; Version 1.2; 29 November 2022). The running approved protocol version is v1.3, dated 07 May 2024. Results of this study will be submitted for publication in peer-reviewed journals. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov ID: NCT05862363. Registered on 08 February 2023. https://clinicaltrials.gov/study/NCT05862363 . FAU - Hossain, Md Shabab AU - Hossain MS AD - Nutrition Research Division (NRD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh. dr.shabab@icddrb.org. FAU - Mahfuz, Mustafa AU - Mahfuz M AD - Nutrition Research Division (NRD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh. FAU - Rahman, M Masudur AU - Rahman MM AD - Department of Gastroenterology, Manikganj Medical College, Dhaka, Bangladesh. AD - Department of Gastrointestinal, Hepatobiliary and Pancreatic Disorders, Bangladesh Specialized Hospital, Dhaka, Bangladesh. FAU - Begum, S M Khodeza Nahar AU - Begum SMKN AD - Department of Histopathology & Cytology, Bangladesh Specialized Hospital, Dhaka, Bangladesh. AD - Department of Pathology, Dr Sirajul Islam Medical College, Dhaka, Bangladesh. FAU - Sarker, Shafiqul Alam AU - Sarker SA AD - Nutrition Research Division (NRD), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh. FAU - Ahmed, Tahmeed AU - Ahmed T AD - Office of Executive Director (OED), International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b), Dhaka, Bangladesh. AD - Department of Global Health, University of Washington, Seattle, WA, United States of America. LA - eng SI - ClinicalTrials.gov/NCT05862363 GR - INV-045337/GATES/Gates Foundation/United States PT - Clinical Trial Protocol PT - Journal Article DEP - 20260206 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - 0 (Dietary Proteins) SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Pregnancy MH - Young Adult MH - *Dietary Proteins/administration & dosage MH - *Dietary Supplements MH - Duodenum/microbiology MH - Feces/microbiology MH - *Gastrointestinal Microbiome MH - *Intestinal Diseases/microbiology MH - *Intestine, Small/microbiology/pathology MH - *Malnutrition/microbiology/complications MH - *Pregnancy Complications/microbiology PMC - PMC12977528 OTO - NOTNLM OT - Environmental enteric dysfunction OT - Gut microbiota OT - Maternal undernutrition OT - Microbiota directed balanced energy protein OT - Pregnancy COIS- Declarations. Ethics approval and consent to participate: Ethical Review Committee of icddr,b (protocol no: PR-22117; Version 1.2; 29 November 2022). The running approved protocol version is v1.3, dated 07 May 2024. Each participant enrolled in the study is treated according to what is morally right and proper. After complete disclosure, a signed written informed consent statement is obtained from each subject. If the subject agrees to participate in the study, they sign the consent form or provide an impression of their thumb. For endoscopy and supplement intervention, a separate consent form is used and the aforementioned procedure is followed. The consent form for endoscopy clearly and fully describes, and demystifies, all aspects of the process, including the risks related with the procedure. No information is remained withheld from the participant. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/07 06:33 MHDA- 2026/06/27 06:45 PMCR- 2026/02/06 CRDT- 2026/02/07 00:09 PHST- 2025/07/22 00:00 [received] PHST- 2026/01/23 00:00 [accepted] PHST- 2026/06/27 06:45 [medline] PHST- 2026/02/07 06:33 [pubmed] PHST- 2026/02/07 00:09 [entrez] PHST- 2026/02/06 00:00 [pmc-release] AID - 10.1186/s12884-026-08710-4 [pii] AID - 8710 [pii] AID - 10.1186/s12884-026-08710-4 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Feb 6;26(1):248. doi: 10.1186/s12884-026-08710-4. PMID- 41652183 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1476-5497 (Electronic) IS - 0307-0565 (Print) IS - 0307-0565 (Linking) VI - 50 IP - 2 DP - 2026 Feb TI - Sex-dependent associations of childhood maltreatment with obesity-related traits: results from the German National Cohort (NAKO). PG - 329-337 LID - 10.1038/s41366-025-01914-2 [doi] AB - BACKGROUND: The relationship between childhood maltreatment (CM) and obesity is nuanced, and recent evidence suggests stronger associations between CM and obesity-related traits in females compared to males. This study aims to validate and extend these findings in a large sample from the German National Cohort (NAKO). METHODS: The NAKO is a population-based cohort study including 204,744 adults. For the present analyses, 151,143 individuals (74,596 female) were included. CM was assessed using the Childhood Trauma Screener (CTS). From the CTS, an overall severity score (CTS sum score), a cumulative CM score (number of CM subtypes with at least moderate severity), and five CTS subtypes were considered as exposures. Obesity-related traits included anthropometric (height, weight, body mass index [BMI], waist circumference [WC]) and body fat markers (relative fat mass [rFM], subcutaneous [SAT], visceral adipose tissue [VAT]). Sex-stratified linear and logistic regression models were adjusted for age, education, and examination center to associate CTS-based scores with obesity-related traits. RESULTS: Associations of the CTS sum score with weight, BMI, WC, rFM, and SAT were stronger in females compared to males, while similar associations were observed for VAT. In both sexes, most obesity-related traits exhibited dose-response relationships with increasing numbers of CM subtypes. Compared to unexposed females, females with exposure to >/=3 CM subtypes had a higher risk for obesity (i.e., BMI >/= 30 kg/m(2); OR = 1.56; 95% CI: 1.43, 1.71) and high WC (i.e., WC >/= 88 cm; OR = 1.39; 95% CI: 1.29, 1.50). In males, exposure to >/=3 CM subtypes was also associated with increased obesity risk (OR = 1.51; 95% CI: 1.32, 1.72) and high WC (i.e., WC >/= 102 cm; OR = 1.31; 95% CI: 1.18, 1.44). Physical and emotional abuse exhibited the strongest average associations and were associated with the most outcomes. CONCLUSION: Associations of CM exposure with adult anthropometric and body fat markers are stronger in females compared to males. CI - (c) 2026. The Author(s). FAU - Topfer, Philipp AU - Topfer P AUID- ORCID: 0000-0002-0041-6538 AD - Department of Internal Medicine A, University Medicine Greifswald, Greifswald, Germany. Philipp.toepfer@med.uni-greifswald.de. FAU - Klinger-Konig, Johanna AU - Klinger-Konig J AD - Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. FAU - Siewert-Markus, Ulrike AU - Siewert-Markus U AD - Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. FAU - Schipf, Sabine AU - Schipf S AD - Institute for Community Medicine, Department SHIP Clinical-Epidemiological Research, University Medicine Greifswald, Greifswald, Germany. FAU - Fischer, Beate AU - Fischer B AD - Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany. FAU - Sedlmeier, Anja M AU - Sedlmeier AM AD - Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany. AD - Center for Translational Oncology, University Hospital Regensburg, Regensburg, Germany. AD - Bavarian Cancer Research Center (BZKF), Regensburg, Germany. FAU - Hebestreit, Antje AU - Hebestreit A AUID- ORCID: 0000-0001-7354-5958 AD - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Ahrens, Wolfgang AU - Ahrens W AUID- ORCID: 0000-0003-3777-570X AD - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Berger, Klaus AU - Berger K AD - Institute of Epidemiology and Social Medicine, University of Munster, Munster, Germany. FAU - Brenner, Hermann AU - Brenner H AUID- ORCID: 0000-0002-6129-1572 AD - Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. AD - Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumour Diseases (NCT), Heidelberg, Germany. AD - German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. FAU - Do, Stefanie AU - Do S AD - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Bremen, Germany. FAU - Heise, Jana-Kristin AU - Heise JK AD - Department of Epidemiology, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany. FAU - Jaskulski, Stefanie AU - Jaskulski S AD - Institute for Prevention and Cancer Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany. FAU - Karch, Andre AU - Karch A AD - Institute of Epidemiology and Social Medicine, University of Munster, Munster, Germany. FAU - Keil, Thomas AU - Keil T AUID- ORCID: 0000-0002-9108-3360 AD - Institute of Social Medicine, Epidemiology and Health Economics, Charite-University Medicine Berlin, Berlin, Germany. AD - Institute for Clinical Epidemiology and Biometry, University of Wurzburg, Wurzburg, Germany. AD - State Institute of Health I, Bavarian State Office for Health and Food Safety, Erlangen, Germany. FAU - Klett-Tammen, Carolina AU - Klett-Tammen C AD - Department of Epidemiology, Helmholtz Center for Infection Research (HZI), Braunschweig, Germany. FAU - Leitzmann, Michael F AU - Leitzmann MF AD - Department of Epidemiology and Preventive Medicine, University of Regensburg, Regensburg, Germany. FAU - Peters, Annette AU - Peters A AUID- ORCID: 0000-0001-6645-0985 AD - Institute of Epidemiology, Helmholtz Zentrum Munchen-German Research Center for Environmental Health (GmbH), Neuherberg, Germany. AD - Institute for Medical Information Processing, Biometry and Epidemiology, Medical Faculty, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. AD - German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany. AD - German Center for Mental Health (DZPG), Partner Site Munich, Munich, Germany. FAU - Schmidt, Borge AU - Schmidt B AD - Institute for Medical Informatics, Biometry and Epidemiology, University Hospital Essen, University Duisburg-Essen, Essen, Germany. FAU - Schulze, Matthias B AU - Schulze MB AUID- ORCID: 0000-0002-0830-5277 AD - Department of Molecular Epidemiology, German Institute of Human Nutrition, Potsdam-Rehbruecke, Nuthetal, Germany. AD - Institute of Nutritional Science, University of Potsdam, Nuthetal, Germany. FAU - Willich, Stefan N AU - Willich SN AD - Institute of Social Medicine, Epidemiology and Health Economics, Charite-University Medicine Berlin, Berlin, Germany. FAU - Dorr, Marcus AU - Dorr M AD - Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany. AD - German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany. FAU - Volzke, Henry AU - Volzke H AD - Institute for Community Medicine, Department SHIP Clinical-Epidemiological Research, University Medicine Greifswald, Greifswald, Germany. FAU - Markus, Marcello R P AU - Markus MRP AUID- ORCID: 0000-0002-6234-4955 AD - Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany. AD - German Centre for Cardiovascular Research (DZHK), Partner Site Greifswald, Greifswald, Germany. FAU - Stracke, Sylvia AU - Stracke S AD - Department of Internal Medicine A, University Medicine Greifswald, Greifswald, Germany. FAU - Grabe, Hans J AU - Grabe HJ AD - Department of Psychiatry and Psychotherapy, University Medicine Greifswald, Greifswald, Germany. AD - German Center for Neurodegenerative Diseases (DZNE), Site Rostock/Greifswald, Greifswald, Germany. FAU - Ittermann, Till AU - Ittermann T AD - Institute for Community Medicine, Department SHIP Clinical-Epidemiological Research, University Medicine Greifswald, Greifswald, Germany. LA - eng PT - Journal Article DEP - 20260206 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM MH - Humans MH - Female MH - Male MH - Germany/epidemiology MH - *Obesity/epidemiology MH - Cohort Studies MH - Sex Factors MH - Body Mass Index MH - Adult MH - Middle Aged MH - *Child Abuse/statistics & numerical data MH - Child MH - Risk Factors PMC - PMC12913021 COIS- Competing interests: The authors declare no competing interests. Ethical approval: The authors assert that all procedures contributing to this work comply with the ethical standards of the relevant national and institutional committees on human experimentation and with the Helsinki Declaration of 1975, as revised in 2008. The NAKO obtained ethics approval from all local committees of the study centers. All participants provided written informed consent. EDAT- 2026/02/07 00:31 MHDA- 2026/02/18 00:49 PMCR- 2026/02/06 CRDT- 2026/02/06 23:32 PHST- 2025/01/30 00:00 [received] PHST- 2025/09/09 00:00 [accepted] PHST- 2025/08/19 00:00 [revised] PHST- 2026/02/18 00:49 [medline] PHST- 2026/02/07 00:31 [pubmed] PHST- 2026/02/06 23:32 [entrez] PHST- 2026/02/06 00:00 [pmc-release] AID - 10.1038/s41366-025-01914-2 [pii] AID - 1914 [pii] AID - 10.1038/s41366-025-01914-2 [doi] PST - ppublish SO - Int J Obes (Lond). 2026 Feb;50(2):329-337. doi: 10.1038/s41366-025-01914-2. Epub 2026 Feb 6. PMID- 41652020 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260728 IS - 1476-5454 (Electronic) IS - 0950-222X (Print) IS - 0950-222X (Linking) VI - 40 IP - 5 DP - 2026 Apr TI - Impact of multiple births on retinopathy of prematurity in preterm infants. PG - 624-629 LID - 10.1038/s41433-026-04247-0 [doi] AB - BACKGROUND/OBJECTIVES: To examine how multiple birth status affects the incidence and severity of retinopathy of prematurity (ROP) in preterm infants. With increasing multiple births associated with assisted reproductive technology, this study seeks to clarify these risks independently of gestational age (GA) and birth weight (BW). SUBJECTS/METHODS: This retrospective observational study included 4392 preterm infants screened for ROP between 2010 and 2023. Eligibility criteria were GA /=200 mg/dL. Both risk scores showed positive, dose-response relationships with CIMT, PWV, and AIx (p-trend<0.001), with each SD increase in CVD-scores associated with clinically meaningful increases in all three markers of sub-clinical atheroscerosis. CONCLUSION: Non-laboratory-based WHO and GLOBORISK CVD risk scores exhibit high overall agreement with laboratory-based models and correlate strongly with subclinical atherosclerosis in rural India. However, modest underestimation in high-risk subgroups (diabetics, hypercholesterolemia) warrants cautious interpretation. These findings support the feasibility of non-lab risk assessment in resource-constrained settings, while underscoring the need for prospective validation against hard cardiovascular outcomes prior to large-scale implementation. CI - Copyright: (c) 2026 Mahajan et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Mahajan, Hemant AU - Mahajan H AUID- ORCID: 0000-0001-7874-9191 AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. FAU - Mallinson, Poppy Alice Carson AU - Mallinson PAC AD - London School of Hygiene & Tropical Medicine, London, United Kingdom. FAU - Lieber, Judith AU - Lieber J AD - London School of Hygiene & Tropical Medicine, London, United Kingdom. FAU - Bhogadi, Santhi AU - Bhogadi S AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. FAU - Banjara, Santosh Kumar AU - Banjara SK AUID- ORCID: 0000-0002-0893-9552 AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. FAU - Shah, Anoop AU - Shah A AD - London School of Hygiene & Tropical Medicine, London, United Kingdom. FAU - Gupta, Vipin AU - Gupta V AD - University of Delhi, Delhi, India. FAU - Walia, Gagandeep Kaur AU - Walia GK AD - Public Health Foundation of India, Delhi, India. FAU - Kulkarni, Bharati AU - Kulkarni B AD - Indian Council of Medical Research - National Institute of Nutrition, Hyderabad, India. FAU - Kinra, Sanjay AU - Kinra S AD - London School of Hygiene & Tropical Medicine, London, United Kingdom. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260206 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Male MH - Cross-Sectional Studies MH - *Cardiovascular Diseases/epidemiology/diagnosis MH - Adult MH - Female MH - Aged MH - Middle Aged MH - World Health Organization MH - India/epidemiology MH - Risk Assessment/methods MH - Risk Factors MH - Cohort Studies MH - Algorithms PMC - PMC12880651 COIS- No authors have competing interests. EDAT- 2026/02/06 18:30 MHDA- 2026/02/06 18:31 PMCR- 2026/02/06 CRDT- 2026/02/06 13:43 PHST- 2025/07/21 00:00 [received] PHST- 2026/01/23 00:00 [accepted] PHST- 2026/02/06 18:31 [medline] PHST- 2026/02/06 18:30 [pubmed] PHST- 2026/02/06 13:43 [entrez] PHST- 2026/02/06 00:00 [pmc-release] AID - PONE-D-25-38253 [pii] AID - 10.1371/journal.pone.0342471 [doi] PST - epublish SO - PLoS One. 2026 Feb 6;21(2):e0342471. doi: 10.1371/journal.pone.0342471. eCollection 2026. PMID- 41649858 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 28 DP - 2026 Feb 6 TI - The Feasibility of Smartwatch Micro-Ecological Momentary Assessment for Tracking Eating Patterns of Malaysian Children and Adolescents in the South-East Asian Community Observatory Child Health Update 2020: Cross-Sectional Study. PG - e73435 LID - 10.2196/73435 [doi] LID - e73435 AB - BACKGROUND: Mobile phone ecological momentary assessment (EMA) methods are a well-established measure of eating and drinking behaviors, but compliance can be poor. Micro-EMA (muEMA), which collects information with a single tap response to brief questions on smartwatches, offers a novel application that may improve response rates. To our knowledge, there is no data evaluating muEMA to measure eating habits in children or in low-to-middle-income countries. OBJECTIVE: In this study, we investigated the feasibility of micro-EMA to measure eating patterns in Malaysian children and adolescents. METHODS: We invited 100 children and adolescents aged 7-18 years in Segamat, Malaysia, to participate in 2021-2022. Smartwatches were distributed to 83 children and adolescents who agreed to participate. Participants were asked to wear the smartwatch for 8 days and respond to 12 prompts per day, hourly, from 9AM to 8PM, asking for information on their meals, snacks, and drinks consumed. A questionnaire captured their experiences using the smartwatch and muEMA interface. Response rate (proportion of prompts responded to) assessed participants' adherence. We explored associations between response rate with time of day, across days, age, and sex using multilevel binomial logistic regression modeling. RESULTS: Eighty-two participants provided usable smartwatch data. The median number (IQR) of meals, drinks, and snacks per day was 2 (2-4), 3 (1-5), and 1 (0-2), respectively, on the first day of the study. The median response rate across the study was 68% (IQR 50-83). The response rate decreased across study days from 74% (68-78) on Day 1 to 40% (30-50) on Day 7 (odds ratio [OR] per study day 0.73, 95% CI 0.64-0.83). Response rate was lowest at the start of the day and highest between the hours of 12 PM and 2 PM. Female participants responded to more prompts than male participants (OR 1.72, 95% CI 1.03-2.86). There was no evidence of differential response by age (OR 0.73, 95% CI 0.41-1.28). Most participants (65%) rated their experience using the smartwatch positively, with 33% saying they were happy to participate in future studies using the smartwatch. For children that did not wear the smartwatch for the full study duration (n=22), discomfort was the most common complaint (41%). CONCLUSIONS: In this study of the feasibility of muEMA on smartwatches to measure eating in Malaysian children, we found the method was acceptable. However, response rates declined across study days, resulting in substantial missingness. Future studies (eg, through focus groups) should explore approaches to improving response to event prompts, trial alternative devices to increase children's comfort, and evaluate revised protocols for reporting of intake events. CI - (c)Richard Lane, Louise A C Millard, Ruth Salway, Chris J Stone, Andy L Skinner, Sophia M Brady, Jeevitha Mariapun, Sutha Rajakumar, Amutha Ramadas, Hussein Rizal, Laura Johnson, Tin Tin Su, Miranda Elaine Glynis Armstrong. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 06.02.2026. FAU - Lane, Richard AU - Lane R AUID- ORCID: 0000-0002-2360-2392 AD - Jean Golding Institute, University of Bristol, Bristol, United Kingdom. FAU - Millard, Louise A C AU - Millard LAC AUID- ORCID: 0000-0003-4787-8411 AD - MRC Integrative Epidemiology Unit, University of Bristol, Bristol, United Kingdom. FAU - Salway, Ruth AU - Salway R AUID- ORCID: 0000-0002-3242-3951 AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom. FAU - Stone, Chris J AU - Stone CJ AUID- ORCID: 0000-0001-9697-9353 AD - Integrative Cancer Epidemiology Programme, School of Psychological Science, University of Bristol, Bristol, United Kingdom. FAU - Skinner, Andy L AU - Skinner AL AUID- ORCID: 0000-0001-7019-163X AD - Bristol Medical School, Integrative Cancer Epidemiology Programme, University of Bristol, Bristol, United Kingdom. FAU - Brady, Sophia M AU - Brady SM AUID- ORCID: 0000-0003-4297-261X AD - Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, United Kingdom. FAU - Mariapun, Jeevitha AU - Mariapun J AUID- ORCID: 0000-0003-3421-0527 AD - South East Asia Community Observatory (SEACO), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya, Malaysia. FAU - Rajakumar, Sutha AU - Rajakumar S AUID- ORCID: 0000-0002-5303-6715 AD - South East Asia Community Observatory (SEACO), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya, Malaysia. FAU - Ramadas, Amutha AU - Ramadas A AUID- ORCID: 0000-0002-8238-9659 AD - South East Asia Community Observatory (SEACO), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya, Malaysia. FAU - Rizal, Hussein AU - Rizal H AUID- ORCID: 0000-0001-9229-1586 AD - South East Asia Community Observatory (SEACO), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya, Malaysia. FAU - Johnson, Laura AU - Johnson L AUID- ORCID: 0000-0001-8985-3154 AD - Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, United Kingdom. FAU - Su, Tin Tin AU - Su TT AUID- ORCID: 0000-0003-0387-6406 AD - South East Asia Community Observatory (SEACO), Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Subang Jaya, Malaysia. FAU - Armstrong, Miranda Elaine Glynis AU - Armstrong MEG AUID- ORCID: 0000-0001-8946-5776 AD - Department for Health, University of Bath, Bath, England, United Kingdom. AD - NIHR Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, United Kingdom. LA - eng PT - Journal Article DEP - 20260206 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 SB - IM MH - Humans MH - Child MH - Adolescent MH - Male MH - Malaysia MH - *Ecological Momentary Assessment MH - Female MH - Cross-Sectional Studies MH - Feasibility Studies MH - *Feeding Behavior MH - Cell Phone MH - Digital Health PMC - PMC12924041 OTO - NOTNLM OT - EMA OT - LMIC OT - Malaysia OT - adolescents OT - children OT - eating behavior OT - ecological momentary assessment OT - micro-interaction EMA OT - smartwatch OT - muEMA COIS- Conflicts of Interest: None declared. EDAT- 2026/02/06 14:37 MHDA- 2026/02/06 18:31 PMCR- 2026/02/06 CRDT- 2026/02/06 11:52 PHST- 2025/05/01 00:00 [received] PHST- 2025/12/30 00:00 [accepted] PHST- 2025/11/18 00:00 [revised] PHST- 2026/02/06 18:31 [medline] PHST- 2026/02/06 14:37 [pubmed] PHST- 2026/02/06 11:52 [entrez] PHST- 2026/02/06 00:00 [pmc-release] AID - v28i1e73435 [pii] AID - 10.2196/73435 [doi] PST - epublish SO - J Med Internet Res. 2026 Feb 6;28:e73435. doi: 10.2196/73435. PMID- 41648934 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 2047-2986 (Electronic) IS - 2047-2978 (Print) IS - 2047-2978 (Linking) VI - 16 DP - 2026 Feb 6 TI - Associations of sedentary behaviour and physical activity with stress-related sleep disturbance among adolescents in 69 countries: a population-based study. PG - 04049 LID - 10.7189/jogh.16.04049 [doi] LID - 04049 AB - BACKGROUND: Stress-related sleep disturbance have become a serious public health problem among adolescents worldwide. There is a paucity of research employing standardised methodologies to evaluate the association between sedentary behaviour, physical activity, and stress-related sleep disturbance among adolescents. We aimed to examine the association between sedentary behaviour and/or physical activity with stress-related sleep disturbance among adolescents worldwide. METHODS: We used data from the Global School-based Student Health Survey (GSHS) conducted from 2010 to 2019, encompassing 275 483 adolescents aged 12-17 years across 69 countries. Multi-variable logistic regression analysis was performed to assess the independent and joint effect of sedentary behaviour and physical activity on stress-related sleep disturbance. RESULTS: 30.0% of adolescents spend >/=2 hours in sedentary behaviour daily, only 15.4% engage in physical activity for over one hour each day, and 8.3% of adolescents suffer from stress-related sleep disturbances. Compared with those who engaged sedentary behaviour <2 hours/day, 3-4 hours (odds ratio (OR) = 1.168; 95% CI = 1.027-1.329), 5-6 hours (OR = 1.413; 95% CI = 1.169-1.707), and >/=7 hours (OR = 1.792; 1.548-2.076) of daily sedentary behaviour are positively associated with stress-related sleep disturbances among adolescents. Compared with adolescents with low sedentary behaviour and sufficient physical activity, adolescents with low sedentary behaviour and insufficient physical activity (OR = 1.303; 95% CI = 1.052-1.615), high sedentary behaviour and insufficient physical activity (OR = 1.666; 95% CI = 1.350-2.056), and adolescents with high sedentary behaviour and sufficient physical activity (OR = 1.852; 95% CI = 1.432-2.396) are positively associated with stress-related sleep disturbance. CONCLUSIONS: Sedentary behaviour is associated with a higher risk of stress-related sleep disturbances among adolescents. Reducing sedentary behaviour time may serve as a potential intervention strategy for addressing stress-related sleep disturbances, while the potential benefits of increasing physical activity require further research and validation. CI - Copyright (c) 2026 by the Journal of Global Health. All rights reserved. FAU - Li, Jingpeng AU - Li J AD - Department of Epidemiology and Health Statistics, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, China. FAU - Zhu, Yongliang AU - Zhu Y AD - Department of Epidemiology and Health Statistics, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, China. FAU - Huang, Danyi AU - Huang D AD - Department of Epidemiology and Health Statistics, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, China. FAU - Pan, Mengna AU - Pan M AD - Department of Epidemiology and Health Statistics, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, China. FAU - Li, Fei AU - Li F AD - Department of children and wellness, The First Dongguan Affiliated Hospital, Guangdong Medical University, Dongguan, China. FAU - Li, Liuqing AU - Li L AD - Department of Preventive Medicine, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, China. FAU - Sun, Jiahong AU - Sun J AD - Department of Preventive Medicine, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, China. FAU - Ma, Chuanwei AU - Ma C AD - Department of Epidemiology and Health Statistics, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, China. FAU - Zhang, Bingsong AU - Zhang B AD - Department of Epidemiology and Health Statistics, The First Dongguan Affiliated Hospital, School of Public Health, Guangdong Medical University, Dongguan, China. LA - eng PT - Journal Article DEP - 20260206 PL - Scotland TA - J Glob Health JT - Journal of global health JID - 101578780 SB - IM MH - Humans MH - Adolescent MH - *Sedentary Behavior MH - Female MH - Male MH - *Sleep Wake Disorders/epidemiology MH - *Exercise/psychology MH - *Stress, Psychological/epidemiology/complications MH - Child MH - *Global Health/statistics & numerical data MH - Health Surveys PMC - PMC12879260 COIS- Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests. EDAT- 2026/02/06 13:18 MHDA- 2026/02/06 13:19 PMCR- 2026/02/06 CRDT- 2026/02/06 06:32 PHST- 2026/02/06 13:19 [medline] PHST- 2026/02/06 13:18 [pubmed] PHST- 2026/02/06 06:32 [entrez] PHST- 2026/02/06 00:00 [pmc-release] AID - jogh-16-04049 [pii] AID - 10.7189/jogh.16.04049 [doi] PST - epublish SO - J Glob Health. 2026 Feb 6;16:04049. doi: 10.7189/jogh.16.04049. PMID- 41647257 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260206 LR - 20260605 IS - 2673-6101 (Electronic) IS - 2673-6101 (Print) IS - 2673-6101 (Linking) VI - 7 DP - 2026 TI - Clinical evaluation of pediatric olfactory disorders: a review from etiology to management. PG - 1741382 LID - 10.3389/falgy.2026.1741382 [doi] LID - 1741382 AB - Olfactory perception plays a fundamental role in nutrition, emotional development, and social behavior, yet olfactory disorders (OD) in children remain largely underrecognized and understudied. This mini review summarizes current evidence and proposes a structured clinical approach for the evaluation and management of pediatric OD. Etiologies are diverse, encompassing congenital syndromes such as Kallmann and CHARGE, post-infectious and post-traumatic forms, inflammatory airway diseases, and structural or iatrogenic causes. Accurate diagnosis begins with a detailed medical history and comprehensive ENT examination, complemented by psychophysical olfactory testing adapted for pediatric populations. Although several validated tools exist-such as the Sniffin' Sticks, U-Sniff, Pediatric Smell Wheel, and pBOT-6-standardized age-specific protocols and normative data remain limited. Imaging techniques, particularly MRI, provide valuable insights into congenital and acquired abnormalities of the olfactory bulbs and tracts, while CT is reserved for sinonasal or bony pathology. Multidisciplinary collaboration among pediatricians, neurologists, endocrinologists, geneticists, and otolaryngologists is essential to achieve etiological precision. Management strategies depend on the underlying cause and include medical or surgical treatment for reversible conditions, intranasal corticosteroids for inflammatory diseases, and olfactory training for post-infectious or congenital forms. Regular follow-up with objective testing and family education supports recovery and long-term adaptation. Despite the scarcity of pediatric-specific evidence, this review highlights the need for awareness, early diagnosis, and individualized management of OD in children, proposing a practical diagnostic and therapeutic framework to guide clinical decision-making in everyday ENT practice. A structured search strategy was applied to summarize the currently available evidence and highlight practical implications for clinical care. CI - (c) 2026 Trecca, Reale, Leone, Cassano, della Volpe, La Mantia, Pagella and Cantone. FAU - Trecca, Eleonora M C AU - Trecca EMC AD - Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital of Foggia, Foggia, Italy. FAU - Reale, Marella AU - Reale M AD - Otorhinolaryngology Unit, Head and Neck Department, Meyer Children's Hospital IRCCS, Florence, Italy. FAU - Leone, Luca AU - Leone L AD - Otorhinolaryngology Unit, Head and Neck Department, Meyer Children's Hospital IRCCS, Florence, Italy. FAU - Cassano, Michele AU - Cassano M AD - Department of Otorhinolaryngology-Head and Neck Surgery, University Hospital of Foggia, Foggia, Italy. FAU - Della Volpe, Antonio AU - Della Volpe A AD - Otolaryngology Department, Santobono-Posillipon Hospital, Naples, Italy. FAU - La Mantia, Ignazio AU - La Mantia I AD - Department of Medical and Surgical Sciences and Advanced Technologies "GF Ingrassia", ENT Section, University of Catania, Catania, Italy. FAU - Pagella, Fabio AU - Pagella F AD - Department of Surgical Science, University of Pavia, Pavia, Italy. AD - Department of Otorhinolaryngology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy. FAU - Cantone, Elena AU - Cantone E AD - Department of Pharmacy, Health and Nutrition Sciences, University of Calabria (UNICAL), Cosenza, Italy. AD - Otolaryngology Unit, Annunziata Hospital, Cosenza, Italy. LA - eng PT - Journal Article PT - Review DEP - 20260121 PL - Switzerland TA - Front Allergy JT - Frontiers in allergy JID - 9918227355906676 CIN - Front Allergy. 2026 May 20;7:1834778. doi: 10.3389/falgy.2026.1834778. PMID: 42245187 PMC - PMC12868189 OTO - NOTNLM OT - Kallman syndrome OT - adenoid hypertrophy OT - hyposmia OT - olfactory assessment OT - olfactory training OT - otolaryngology OT - pediatric olfactory disorder COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/06 13:17 MHDA- 2026/02/06 13:18 PMCR- 2026/01/21 CRDT- 2026/02/06 06:11 PHST- 2025/11/07 00:00 [received] PHST- 2025/12/09 00:00 [revised] PHST- 2026/01/02 00:00 [accepted] PHST- 2026/02/06 13:18 [medline] PHST- 2026/02/06 13:17 [pubmed] PHST- 2026/02/06 06:11 [entrez] PHST- 2026/01/21 00:00 [pmc-release] AID - 10.3389/falgy.2026.1741382 [doi] PST - epublish SO - Front Allergy. 2026 Jan 21;7:1741382. doi: 10.3389/falgy.2026.1741382. eCollection 2026. PMID- 41646892 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260206 LR - 20260208 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 16 DP - 2025 TI - Personalized recommendation algorithm for rehabilitation intervention in children with autism spectrum disorder based on the cognitive diagnosis model. PG - 1696155 LID - 10.3389/fpsyg.2025.1696155 [doi] LID - 1696155 AB - AIM: This study applied the Cognitive Diagnostic Model (CDM) to develop a personalized recommendation algorithm for rehabilitation intervention in children and adolescents with autism spectrum disorder (ASD). METHODS: A total of 3,319 children and adolescents were included. Model selections recommended the Generalized Deterministic Input, Noisy "Or" Gate Model (GDINA), to simulate the response pattern of participants in the Autism Behavior Checklist. RESULTS: Both absolute and relative indices confirmed that the response pattern of the participants displayed acceptable fitness to GDINA. Twenty-eight symptom modalities were identified, but only 12 were assigned to over one percent of this sample. Language dysfunction is commonly observed. A diagram of the possible developmental trajectory of participants with ASD indicates that sensory and related functions can be primary targets for those with severe autistic symptoms. One possible rehabilitation route was identified in this diagram that involved 2,621 participants. A detailed personalized analysis was demonstrated in randomly selected cases from this sample. CONCLUSION: Our study developed a personalized recommended algorithm using CDM in designing individualized interventions for children and adolescents with ASD. First, our results confirmed the heterogeneity of ASD symptoms. Importantly, the information derived from the CDM allowed for the construction of a possible development diagram of the functions defined by ABC. Although these results are theoretically sound and reasonable, they remain data-driven. Further empirical validation, particularly through experience with rigorous design, is necessary to confirm the alignment between real-world practices and data-driven models. CI - Copyright (c) 2026 Shu, Peng, Liu, Zhu, Wang and Gao. FAU - Shu, Tian AU - Shu T AD - Jiangxi Education Evaluation And Assessment Institute, Nan Chang, China. FAU - Peng, Kanglong AU - Peng K AD - Rehabilitation Department, Shenzhen Children's Hospital, Shenzhen, China. FAU - Liu, Qing AU - Liu Q AD - Rehabilitation Department, Shenzhen Children's Hospital, Shenzhen, China. FAU - Zhu, Youqi AU - Zhu Y AD - Jiangxi Provincial Education Department Teaching and Textbook Research Institute, Nan Chang, China. FAU - Wang, Jing AU - Wang J AD - Shenzhen Cuiyuandongxiao Middle School, Shenzhen, China. FAU - Gao, Li AU - Gao L AD - Rehabilitation Department, Shenzhen Children's Hospital, Shenzhen, China. LA - eng PT - Journal Article DEP - 20260121 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12868240 OTO - NOTNLM OT - ASD OT - cognitive diagnostic model OT - data-driven model OT - machine learning OT - personalized intervention COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/06 13:17 MHDA- 2026/02/06 13:18 PMCR- 2026/01/21 CRDT- 2026/02/06 06:09 PHST- 2025/09/02 00:00 [received] PHST- 2025/12/09 00:00 [revised] PHST- 2025/12/15 00:00 [accepted] PHST- 2026/02/06 13:18 [medline] PHST- 2026/02/06 13:17 [pubmed] PHST- 2026/02/06 06:09 [entrez] PHST- 2026/01/21 00:00 [pmc-release] AID - 10.3389/fpsyg.2025.1696155 [doi] PST - epublish SO - Front Psychol. 2026 Jan 21;16:1696155. doi: 10.3389/fpsyg.2025.1696155. eCollection 2025. PMID- 41645940 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260723 IS - 1365-2214 (Electronic) IS - 0305-1862 (Print) IS - 0305-1862 (Linking) VI - 52 IP - 2 DP - 2026 Mar TI - Transitioning to a Flexible, Tiered, Developmentally Informed Same-Day Screening Model for Preschoolers in Low-Resource Settings. PG - e70242 LID - 10.1111/cch.70242 [doi] LID - e70242 AB - BACKGROUND: The preschool years (ages 3-5) represent a critical window for promoting development and lifelong health. However, in many low-resource settings, developmental delays, sensory impairments and emerging health risks often go undetected. Although early, integrated screening improves outcomes, early childhood care and education (ECCE) platforms in low- and middle-income countries (LMICs) are underutilized for delivering preventive services. Implementation is hindered by limited resources, poor intersectoral coordination, logistical constraints and low caregiver engagement. This study describes the iterative refinement of an initial screening protocol into a proposed flexible, tiered screening model, embedded within a guiding framework tailored to ECCE settings in LMICs. METHODS: An observational, descriptive study was conducted in low-resource urban, peri-urban and rural communities in a central South African province to collect baseline data on preschoolers' development, sensory functioning (vision and hearing), nutrition and health (including blood pressure). The initial multi-indicator protocol was implemented and refined using a Participatory Action Learning and Action Research (PALAR) approach. Feedback from caregivers, ECCE facilitators, interpreters, student fieldworkers and healthcare professionals guided adaptations. RESULTS: Stakeholders identified key barriers, including fragmented caregiver-child scheduling, long assessment sessions, limited interpreter resources, caregiver disengagement and difficulty engaging children with developmental and behavioural challenges. In response, a proposed model was developed to consolidate visits, reduce session duration, enhance interpreter support and streamline screening tools. The flexible, tiered structure of this proposed model allows assessors to tailor screening based on observed functional capacity, improving feasibility, accuracy and cultural responsiveness. It supports scalable application across similar low-resource ECCE contexts. CONCLUSIONS: This developmentally informed, proposed screening model, operating within a flexible framework, offers a context-sensitive, scalable approach to improving early identification and referral in LMIC ECCE settings. Its adaptable structure supports broader implementation, enhances alignment with children's developmental needs and informs future policy and integrated service planning. CI - (c) 2026 The Author(s). Child: Care, Health and Development published by John Wiley & Sons Ltd. FAU - Smith, Robyn AU - Smith R AUID- ORCID: 0000-0001-7454-9926 AD - School of Health and Rehabilitation Sciences, University of the Free State, Bloemfontein, South Africa. FAU - Jordaan, Elizabeth M AU - Jordaan EM AUID- ORCID: 0000-0003-0452-201X AD - Department of Nutrition and Dietetics, School of Health and Rehabilitation Sciences, University of the Free State, Bloemfontein, South Africa. FAU - Russell, Dorothy C AU - Russell DC AUID- ORCID: 0000-0003-2811-0124 AD - Department of Paediatrics and Child Health, School of Clinical Medicine, University of the Free State, Bloemfontein, South Africa. FAU - de Milander, Monique AU - de Milander M AUID- ORCID: 0000-0003-1275-796X AD - Department of Exercise and Sport Sciences, School of Health and Rehabilitation Sciences, University of the Free State, Bloemfontein, South Africa. FAU - van Rooyen, Marlie AU - van Rooyen M AUID- ORCID: 0000-0003-3175-4131 AD - Department of Linguistics and Language Practice, Faculty of the Humanities, University of the Free State, Bloemfontein, South Africa. FAU - Jansen van Vuuren, Xany AU - Jansen van Vuuren X AUID- ORCID: 0000-0002-2080-0158 AD - Department of Linguistics and Language Practice, Faculty of the Humanities, University of the Free State, Bloemfontein, South Africa. FAU - Devenier, Minette AU - Devenier M AUID- ORCID: 0000-0003-2026-7821 AD - Department of Optometry, School of Health and Rehabilitation Sciences, University of the Free State, Bloemfontein, South Africa. FAU - Bonafede, Carmen AU - Bonafede C AUID- ORCID: 0000-0002-8916-5850 AD - School of Health and Rehabilitation Sciences, University of the Free State, Bloemfontein, South Africa. FAU - Louw, Marshe AU - Louw M AUID- ORCID: 0000-0002-3545-2563 AD - Department of Physiotherapy, School of Health and Rehabilitation Sciences, University of the Free State, Bloemfontein, South Africa. FAU - Kruger, Annelize AU - Kruger A AUID- ORCID: 0000-0002-7947-2929 AD - Department of Occupational Therapy, School of Health and Rehabilitation Sciences, University of the Free State, Bloemfontein, South Africa. FAU - Sivhugwana, Innocentia AU - Sivhugwana I AUID- ORCID: 0009-0006-9234-8152 AD - Department of Physiotherapy, School of Health and Rehabilitation Sciences, University of the Free State, Bloemfontein, South Africa. FAU - Nkomo, Thembi AU - Nkomo T AUID- ORCID: 0009-0006-4337-7889 AD - Department of Occupational Therapy, School of Health and Rehabilitation Sciences, University of the Free State, Bloemfontein, South Africa. FAU - van der Merwe, Minzke AU - van der Merwe M AUID- ORCID: 0009-0005-0796-9580 AD - Department of Optometry, School of Health and Rehabilitation Sciences, University of the Free State, Bloemfontein, South Africa. LA - eng PT - Journal Article PT - Observational Study PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM MH - Humans MH - Child, Preschool MH - Resource-Limited Settings MH - *Developmental Disabilities/diagnosis MH - *Mass Screening/organization & administration/methods MH - South Africa MH - *Child Health Services/organization & administration MH - Child Development MH - Developing Countries MH - Male MH - Female MH - Early Intervention, Educational/organization & administration PMC - PMC12878803 OTO - NOTNLM OT - ECCE in low-resource settings OT - LMIC contexts OT - developmental and health screening OT - early childhood development OT - tiered screening model EDAT- 2026/02/06 06:41 MHDA- 2026/02/06 06:42 PMCR- 2026/02/06 CRDT- 2026/02/06 05:22 PHST- 2025/11/11 00:00 [revised] PHST- 2025/07/09 00:00 [received] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/02/06 06:42 [medline] PHST- 2026/02/06 06:41 [pubmed] PHST- 2026/02/06 05:22 [entrez] PHST- 2026/02/06 00:00 [pmc-release] AID - CCH70242 [pii] AID - 10.1111/cch.70242 [doi] PST - ppublish SO - Child Care Health Dev. 2026 Mar;52(2):e70242. doi: 10.1111/cch.70242. PMID- 41645388 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1464-5491 (Electronic) IS - 0742-3071 (Print) IS - 0742-3071 (Linking) VI - 43 IP - 5 DP - 2026 May TI - Picture living with diabetes: A photovoice study of young adults' efforts in making diabetes care fit into their lives. PG - e70246 LID - 10.1111/dme.70246 [doi] LID - e70246 AB - AIM: This study aimed to identify what young adults with type 1 diabetes (T1D) do to make diabetes care fit in their lives and the impact of diabetes and diabetes care on living. METHODS: Dutch young adults with T1D (18-30 years old) submitted photographed real-life situations of efforts to make care fit and of the impact of care on their lives. Participants organised their photos in themes, which guided the focus group discussions. We added a reflective questionnaire, semi-structured interview and iterative validation to identify participant-defined themes and summarise the data. RESULTS: Participants (N = 18) submitted 240 photographs in total, showing a broad range of situations and emotions. Participants identified 16 themes, grouped into four overarching categories describing their experiences with diabetes: (1) My diabetes: glucose levels, workload, 24/7 present; (2) My life: flow of (daily) life, special and irregular circumstances, life changes, body and health; (3) Support: devices and technology, social network, clinical (diabetes) care; (4) Mental aspects: emotional processes, perspective, being a patient. In the overlap of My diabetes and My life, they identified eating and counting carbohydrates, activity and exercise, recreational substances. CONCLUSION: Young adults with T1D face the complex challenge of fitting their care into their ever-changing lives. While support systems, such as devices, healthcare professionals and social networks can help, they can also create burdens. Participants emphasised the importance of mental health in their lives with T1D. This study highlights the need for diabetes care that acknowledges the emotional, social and practical realities of young adults' lives. CI - (c) 2026 The Author(s). Diabetic Medicine published by John Wiley & Sons Ltd on behalf of Diabetes UK. FAU - Van Gastel, Anka AU - Van Gastel A AUID- ORCID: 0009-0009-5020-6326 AD - Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands. AD - Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands. AD - Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, Minnesota, USA. FAU - Graner-Baars, Matthijs AU - Graner-Baars M AD - The Foundation eendiabetes, Amsterdam, The Netherlands. FAU - De Koning, Eelco J P AU - De Koning EJP AUID- ORCID: 0000-0002-1232-7022 AD - Internal Medicine, Leiden University Medical Center, Leiden, The Netherlands. FAU - Montori, Victor M AU - Montori VM AD - Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, Minnesota, USA. AD - Division of Endocrinology, Diabetes & Metabolism, Mayo Clinic College of Medicine, Rochester, Minnesota, USA. FAU - Tran, Viet-Thi AU - Tran VT AD - General Medicine, Paris Diderot University, Paris, France. AD - METHODS Team, Centre for Research in Epidemiology and Statistics (CRESS), Universite Paris Cite, INSERM, Paris, France. AD - Centre d'Epidemiologie Clinique, HopitalHotel-Dieu, Paris, France. FAU - Dinneen, Sean F AU - Dinneen SF AUID- ORCID: 0000-0002-6636-0493 AD - Galway University Hospitals, Galway, Ireland. AD - Department of Medicine, University of Galway, Galway, Ireland. FAU - Mesman, Jessica AU - Mesman J AD - Department of Society Studies, Maastricht University, Maastricht, The Netherlands. FAU - Swaak, Joris AU - Swaak J AD - Panton Medical Design Agency, Deventer, The Netherlands. FAU - Aanstoot, Henk-Jan AU - Aanstoot HJ AD - Diabeter, Center for Pediatric and Adult Diabetes Care and Research, Rotterdam, The Netherlands. FAU - Stiggelbout, Anne M AU - Stiggelbout AM AD - Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands. FAU - Kunneman, Marleen AU - Kunneman M AUID- ORCID: 0000-0001-5334-1085 AD - Biomedical Data Sciences, Leiden University Medical Center, Leiden, The Netherlands. AD - Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, Minnesota, USA. AD - Health Campus the Hague, Department of Public Health and Primary Care, Leiden University Medical Center, The Hague, The Netherlands. LA - eng GR - Diabetes Fonds/ PT - Journal Article DEP - 20260205 PL - England TA - Diabet Med JT - Diabetic medicine : a journal of the British Diabetic Association JID - 8500858 SB - IM MH - Humans MH - *Diabetes Mellitus, Type 1/psychology/therapy MH - Female MH - Young Adult MH - Male MH - Adult MH - Adolescent MH - Photography MH - *Quality of Life MH - Focus Groups MH - Netherlands/epidemiology MH - *Self Care/psychology MH - Social Support MH - Emotions MH - Surveys and Questionnaires MH - Activities of Daily Living PMC - PMC13074116 OTO - NOTNLM OT - activities of daily living OT - community-based participatory research OT - diabetes mellitus OT - making care fit OT - qualitative research OT - type 1 OT - young adult COIS- There are no conflicts of interest. EDAT- 2026/02/06 06:42 MHDA- 2026/04/13 12:37 PMCR- 2026/04/13 CRDT- 2026/02/06 00:09 PHST- 2026/01/15 00:00 [revised] PHST- 2025/09/01 00:00 [received] PHST- 2026/01/21 00:00 [accepted] PHST- 2026/04/13 12:37 [medline] PHST- 2026/02/06 06:42 [pubmed] PHST- 2026/02/06 00:09 [entrez] PHST- 2026/04/13 00:00 [pmc-release] AID - DME70246 [pii] AID - 10.1111/dme.70246 [doi] PST - ppublish SO - Diabet Med. 2026 May;43(5):e70246. doi: 10.1111/dme.70246. Epub 2026 Feb 5. PMID- 41645239 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1748-5908 (Electronic) IS - 1748-5908 (Linking) VI - 21 IP - 1 DP - 2026 Feb 5 TI - Healthy school recognized campus: design and methodology of a hybrid type 2 implementation-effectiveness cluster randomized trial. LID - 10.1186/s13012-026-01487-2 [doi] LID - 19 AB - BACKGROUND: About one-third of U.S. youth are overweight and most have at least one risk factor that increases their chance of developing cardiovascular or other chronic diseases. School- and research-based physical activity and healthy eating programs can reduce obesity and improve health outcomes; however, schools face many implementation challenges. Healthy School Recognized Campus (HSRC) bundles school- and researched-based programs to improve their implementation and student health outcomes. This paper describes the protocol for a hybrid type 2 implementation-effectiveness, cluster dual randomized controlled trial that evaluates the (aim 1) effectiveness of the HSRC initiative for improving health behaviors and (aim 2) the impact of an implementation strategy - school-to-school mentoring - on HSRC's delivery. METHODS: Students in 4th through 9th grade (n = 500) at public schools (n = 20) across East and Central Texas will be randomized at the school level to determine the effectiveness of HSRC (vs. waitlist control condition) on BMI z-score (primary outcome), physical activity measured via accelerometer, and skin carotenoids (i.e., fruit and vegetable intake; secondary outcomes). Assessments will occur at the start and end of one school year. Program implementers (n = 200) at schools will be randomized to assess the impact of the school-to-school mentoring strategy (vs. standard implementation) on HSRC's acceptability, appropriateness, and feasibility (co-primary outcomes). Assessments will occur at the start, middle, and end of one school year. The assessment at the end of the school year will also include a concurrent mixed-methods approach (QUAL + QUAN), guided by the Consolidated Framework for Implementation Research (CFIR), to evaluate the school-to-school mentoring strategy. For quantitative outcomes, a generalized linear model framework will be used to evaluate HSRC and the school-to-school mentoring strategy. DISCUSSION: This study's innovative dual randomized design allows for rigorous assessment of HSRC on effectiveness outcomes and the evaluation of a school-to-school mentoring implementation strategy on implementation outcomes. If both HSRC and the school-to-school mentoring strategy have their hypothesized effect, we will be well positioned to address cardiovascular and other chronic disease risk factors among youth using a scalable, widely used approach within one of the largest health educator networks in the country. TRIAL REGISTRATION: Clinicaltrials.gov on July 1, 2025 (NCT07079995). CI - (c) 2026. This is a U.S. Government work and not under copyright protection in the US; foreign copyright protection may apply. FAU - Schaefers, Allyson AU - Schaefers A AD - Institute for Advancing Health Through Agriculture (IHA), Texas A&M AgriLife Research, 17360 Coit Rd, Dallas, TX, 75252, USA. FAU - Beattie, Cassandra M AU - Beattie CM AD - Institute for Advancing Health Through Agriculture (IHA), Texas A&M AgriLife Research, 17360 Coit Rd, Dallas, TX, 75252, USA. FAU - de Mello, Gabrielli T AU - de Mello GT AD - Institute for Advancing Health Through Agriculture (IHA), Texas A&M AgriLife Research, 17360 Coit Rd, Dallas, TX, 75252, USA. FAU - George, Alisha AU - George A AD - Institute for Advancing Health Through Agriculture (IHA), Texas A&M AgriLife Research, 17360 Coit Rd, Dallas, TX, 75252, USA. FAU - Marstall, Kendra AU - Marstall K AD - Institute for Advancing Health Through Agriculture (IHA), Texas A&M AgriLife Research, 17360 Coit Rd, Dallas, TX, 75252, USA. FAU - Gardner, Julie AU - Gardner J AD - Texas 4-H Youth Development, Texas A&M AgriLife Extension, 1470 William D Fitch Parkway, College Station, TX, 77845, USA. FAU - Szeszulski, Jacob AU - Szeszulski J AD - Institute for Advancing Health Through Agriculture (IHA), Texas A&M AgriLife Research, 17360 Coit Rd, Dallas, TX, 75252, USA. Jacob.Szeszulski@agnet.tamu.edu. LA - eng SI - ClinicalTrials.gov/NCT07079995 GR - 25ISA1473973/American Heart Association/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20260205 PL - England TA - Implement Sci JT - Implementation science : IS JID - 101258411 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Diet, Healthy MH - Exercise MH - Health Behavior MH - *Health Promotion/organization & administration/methods MH - Implementation Science MH - Mentoring MH - Program Evaluation MH - Research Design MH - *School Health Services/organization & administration MH - Schools MH - Texas MH - Randomized Controlled Trials as Topic PMC - PMC12977675 OTO - NOTNLM OT - Adolescent health OT - Body mass index OT - Cooperative extension OT - Exercise OT - Health education OT - Implementation strategy OT - Nutrition OT - Obesity COIS- Declarations. Ethics approval and consent to participate: This protocol was reviewed and approved by a full institutional review board at Texas A&M University (IRB#STUDY2025-0650). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/06 06:42 MHDA- 2026/03/12 07:05 PMCR- 2026/02/05 CRDT- 2026/02/06 00:01 PHST- 2025/12/10 00:00 [received] PHST- 2026/01/29 00:00 [accepted] PHST- 2026/03/12 07:05 [medline] PHST- 2026/02/06 06:42 [pubmed] PHST- 2026/02/06 00:01 [entrez] PHST- 2026/02/05 00:00 [pmc-release] AID - 10.1186/s13012-026-01487-2 [pii] AID - 1487 [pii] AID - 10.1186/s13012-026-01487-2 [doi] PST - epublish SO - Implement Sci. 2026 Feb 5;21(1):19. doi: 10.1186/s13012-026-01487-2. PMID- 41645231 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 1757-7241 (Electronic) IS - 1757-7241 (Linking) VI - 34 IP - 1 DP - 2026 Feb 5 TI - Multimodal large language model versus emergency physicians for burn assessment: a prospective non-inferiority study. LID - 10.1186/s13049-026-01577-6 [doi] LID - 54 AB - BACKGROUND: Accurate burn size and depth assessment at first contact guides fluid resuscitation, referral, and operative planning, yet both tasks show meaningful inter-clinician variability. General-purpose multimodal large language models may offer scalable, image-based decision support in emergency care, but prospective benchmarking against clinicians and a robust reference standard remains limited. METHODS: We conducted a prospective, single-centre diagnostic accuracy and agreement study in a tertiary emergency department (22 July-8 September 2025). Consecutive acute burn presentations (< 24 h) were screened; protocol-conformant cases contributed standardized three-view photographs per anatomically distinct burn region. A multimodal large language model generated region-level estimates of total body surface area (TBSA) contribution and burn depth class. Eighteen emergency physicians independently rated the same images and minimal metadata, blinded to model and reference outputs. A three-member expert panel served as the reference standard by consensus. The primary endpoint was non-inferiority of the model versus the physician median for region-level absolute TBSA error relative to the panel, with a pre-specified margin of 3 percentage points, using patient-level cluster bootstrap for inference. Secondary endpoints included TBSA agreement and depth agreement (quadratic-weighted kappa). RESULTS: Of 413 screened presentations, 52 patients were enrolled, yielding 64 analyzable burn region-cases (35 pediatric, 29 adult). The model's mean absolute TBSA error versus the panel was 1.40 percentage points (median 1.00); 87.5% of cases were within +/- 3 percentage points and 98.4% within +/- 5. The physician median had a mean absolute error of 0.89 percentage points (median 0.75). The paired non-inferiority analysis met the pre-specified criterion (Hodges-Lehmann median Delta = 0.25; one-sided 95% upper bound = 0.50), indicating the model was non-inferior to physicians for TBSA estimation. In contrast, depth agreement versus the panel was slight for the model (quadratic-weighted kappa 0.14), with systematic underestimation of deeper burns, while physician consensus showed substantially higher agreement (quadratic-weighted kappa 0.65). CONCLUSIONS: In this prospective emergency department evaluation, a general-purpose multimodal model achieved non-inferior performance to emergency physicians for region-level TBSA estimation but performed substantially worse for burn depth classification. These findings support a narrowly defined adjunct role for TBSA estimation, while depth-dependent decisions should remain clinician-led and require further method development and external validation. CI - (c) 2026. The Author(s). FAU - Aykut, Ahmet AU - Aykut A AUID- ORCID: 0009-0001-3173-8994 AD - Department of Emergency Medicine, SBU Van Education and Research Hospital, Van, Turkiye. ahmet.aykut@gmail.com. FAU - Karayil, Ali Riza AU - Karayil AR AUID- ORCID: 0000-0002-4080-4455 AD - Department of General Surgery, SBU Van Education and Research Hospital, Van, Turkiye. FAU - Yildirim, Cem AU - Yildirim C AUID- ORCID: 0009-0004-5359-6335 AD - Department of Emergency Medicine, SBU Van Education and Research Hospital, Van, Turkiye. FAU - Gunsoy, Ertug AU - Gunsoy E AUID- ORCID: 0000-0002-9653-3236 AD - Department of Emergency Medicine, SBU Van Education and Research Hospital, Van, Turkiye. FAU - Tatli, Mehmet AU - Tatli M AUID- ORCID: 0000-0001-5907-9161 AD - Department of Emergency Medicine, SBU Van Education and Research Hospital, Van, Turkiye. FAU - Avci, Murat AU - Avci M AUID- ORCID: 0009-0007-0025-1108 AD - Department of Emergency Medicine, SBU Van Education and Research Hospital, Van, Turkiye. LA - eng PT - Equivalence Trial PT - Journal Article DEP - 20260205 PL - England TA - Scand J Trauma Resusc Emerg Med JT - Scandinavian journal of trauma, resuscitation and emergency medicine JID - 101477511 SB - IM MH - Humans MH - *Burns/diagnosis MH - Prospective Studies MH - Large Language Models MH - Female MH - Male MH - Adult MH - Emergency Service, Hospital MH - Middle Aged MH - Body Surface Area MH - *Physicians MH - Child PMC - PMC12969848 OTO - NOTNLM OT - Burns OT - Diagnostic accuracy OT - Emergency medicine OT - Large language model OT - Total body surface area COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Institutional Ethics Committee of SBU. Van Education and Research Hospital (Non-Interventional Clinical Research Ethics Committee) on 09 May 2025 (approval number: GOKAEK/2025-04-06). The study was conducted in accordance with the Declaration of Helsinki and local regulations. Written informed consent for study participation and clinical photography was obtained from all adult participants. For paediatric patients, written informed consent was obtained from a parent or legal guardian, with age-appropriate assent obtained from the child when feasible. Consent for publication: All clinical photographs used in this study were de-identified prior to analysis. Written informed consent for publication of anonymised images and data was obtained from all adult participants, and from parents or legal guardians for paediatric participants. Competing interests: The authors declare no competing interests. EDAT- 2026/02/06 00:31 MHDA- 2026/03/10 08:44 PMCR- 2026/02/05 CRDT- 2026/02/06 00:01 PHST- 2025/12/18 00:00 [received] PHST- 2026/02/03 00:00 [accepted] PHST- 2026/03/10 08:44 [medline] PHST- 2026/02/06 00:31 [pubmed] PHST- 2026/02/06 00:01 [entrez] PHST- 2026/02/05 00:00 [pmc-release] AID - 10.1186/s13049-026-01577-6 [pii] AID - 1577 [pii] AID - 10.1186/s13049-026-01577-6 [doi] PST - epublish SO - Scand J Trauma Resusc Emerg Med. 2026 Feb 5;34(1):54. doi: 10.1186/s13049-026-01577-6. PMID- 41645223 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 23 IP - 1 DP - 2026 Feb 5 TI - The development of the EUropean Physical Activity Determinants framework for Adolescents (EU-PAD-A): a mixed-methods concept mapping study within the DE-PASS COST action. LID - 10.1186/s12966-026-01878-0 [doi] LID - 22 AB - BACKGROUND: Most European adolescents do not meet recommended levels of physical activity (PA), increasing their risk of long-term health issues and contributing to the burden of non-communicable diseases. To address this public health challenge, there is a need for evidence-based, age-specific frameworks that identify the key determinants influencing PA behaviours during adolescence, a critical developmental stage for habit formation. METHODS: This study developed the EUropean Physical Activity Determinants framework for Adolescents (EU-PAD-A) and identified the most important and modifiable factors that can inform targeted interventions and public policy. Using Group Concept Mapping analysis, 240 experts contributed to the identification, sorting, and rating of PA determinants for adolescents. RESULTS: A total number of 110 determinants were grouped into nine thematic clusters. Determinants were rated for importance and modifiability, with 53% (n = 58) scoring high on both dimensions. To refine priorities for policy and practice, a focus group of experts and a survey involving 60 policy makers and stakeholders were conducted. This process led to the identification of the top 10 actionable determinants, defined as those rated highly for importance and modifiability by experts and for impact and feasibility by policy makers and stakeholders, including availability of indoor and outdoor PA facilities, beliefs about PA, and inclusive school programs. CONCLUSIONS: The results highlight school, family, and socio-cultural environments as critical settings for intervention. The EU-PAD-A framework offers a novel, interdisciplinary, and age-specific tool for understanding and addressing the complex drivers of adolescent PA. It provides concrete, consensus-based guidance for designing policies and programs that are feasible, impactful, and grounded in scientific evidence. As such, it represents an important step toward improving PA levels and reducing sedentary behaviour among adolescents across Europe. FAU - Fusco, Andrea AU - Fusco A AD - Department of Medicine and Aging Sciences, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy. FAU - Cortis, Cristina AU - Cortis C AD - Department of Human Sciences, Society and Health, University of Cassino and Lazio Meridionale, Cassino, Italy. c.cortis@unicas.it. FAU - Mork, Paul Jarle AU - Mork PJ AD - Department of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway. FAU - Conte, Daniele AU - Conte D AD - Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy. AD - Department of Coaching Science, Lithuanian Sports University, Kaunas, Lithuania. FAU - Di Rocco, Francesca AU - Di Rocco F AD - Department of Human Sciences, Society and Health, University of Cassino and Lazio Meridionale, Cassino, Italy. FAU - Festino, Emanuel AU - Festino E AD - Department of Human Sciences, Society and Health, University of Cassino and Lazio Meridionale, Cassino, Italy. FAU - Izzicupo, Pascal AU - Izzicupo P AD - Department of Medicine and Aging Sciences, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy. FAU - Orru, Stefania AU - Orru S AD - Department of Medical, Human Movement and Well-Being Sciences, University of Naples Parthenope, Naples, Italy. AD - CEINGE Biotecnologie Avanzate "F. Salvatore", Naples, Italy. FAU - Nordstoga, Anne Lovise AU - Nordstoga AL AD - Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway. FAU - Papale, Olga AU - Papale O AD - Department of Human Sciences, Society and Health, University of Cassino and Lazio Meridionale, Cassino, Italy. FAU - De Maio, Marianna AU - De Maio M AD - Department of Human Sciences, Society and Health, University of Cassino and Lazio Meridionale, Cassino, Italy. FAU - Presta, Valentina AU - Presta V AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. FAU - Rocliffe, Padraic AU - Rocliffe P AD - Department of Physical Education and Sport Sciences, Physical Activity for Health Cluster, Health Research Institute, University of Limerick, Limerick, Ireland. FAU - Capranica, Laura AU - Capranica L AD - Department of Movement, Human and Health Sciences, University of Rome "Foro Italico", Rome, Italy. FAU - MacDonncha, Ciaran AU - MacDonncha C AD - Department of Physical Education and Sport Sciences, Physical Activity for Health Cluster, Health Research Institute, University of Limerick, Limerick, Ireland. FAU - Condello, Giancarlo AU - Condello G AD - Department of Medicine and Surgery, University of Parma, Parma, Italy. LA - eng PT - Journal Article DEP - 20260205 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - Adolescent MH - *Exercise MH - Europe MH - *Adolescent Behavior MH - Focus Groups MH - *Health Promotion/methods MH - Health Behavior MH - Female MH - Male MH - European People MH - Health Policy PMC - PMC12973781 OTO - NOTNLM OT - Adolescent behaviour OT - Concept mapping OT - Health promotion OT - Social environment COIS- Declarations. Ethics approval and consent to participate: The study was approved from the Institutional Review Board of the Department of Human Sciences, Society, and Health of the University of Cassino and Lazio Meridionale (Approval No.: 9407; dated 8 March 2023). Participants provided informed consent to participate in this study. Consent for publication: All the participants gave their consent for publication. Competing interests: The authors declare no competing interests. EDAT- 2026/02/06 00:30 MHDA- 2026/06/28 00:37 PMCR- 2026/02/05 CRDT- 2026/02/06 00:01 PHST- 2025/05/13 00:00 [received] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/06/28 00:37 [medline] PHST- 2026/02/06 00:30 [pubmed] PHST- 2026/02/06 00:01 [entrez] PHST- 2026/02/05 00:00 [pmc-release] AID - 10.1186/s12966-026-01878-0 [pii] AID - 1878 [pii] AID - 10.1186/s12966-026-01878-0 [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2026 Feb 5;23(1):22. doi: 10.1186/s12966-026-01878-0. PMID- 41644024 OWN - NLM STAT- MEDLINE DCOM- 20260925 LR - 20260929 IS - 1532-8503 (Electronic) IS - 1051-2276 (Linking) VI - 36 IP - 5 DP - 2026 Sep TI - Structured Appetite Assessment in Children With Chronic Kidney Disease. PG - 725-729 LID - S1051-2276(26)00012-9 [pii] LID - 10.1053/j.jrn.2026.01.003 [doi] AB - OBJECTIVES: Appetite disturbances are common in children with chronic kidney disease (CKD). Although appetite assessment is recommended in clinical practice, no validated tools exist for structured evaluation. This study explores appetite in pediatric CKD and validates a simplified, user-friendly assessment tool. METHODS: Following its construction, the ModSNAQ tool was assessed for content validity and employed in an observational cross-sectional study of children with CKD to validate it against dietary intake. The ModSNAQ scores were used to explore relationships of appetite and clinical data, including follow-up outcomes of growth and renal function at 12 months. RESULTS: The tool showed excellent content validity. In the cohort of children with CKD (mean glomerular filtration rate = 52 mL/minute/1.73 m(2)), almost a quarter rated their appetite as poor/very poor. Although not correlating with renal function, ModSNAQ scores predicted meeting energy and protein intake and correlated with height. Change in height and renal function at 12 months did not correspond with ModSNAQ scores, but those with poor appetite had an increase in body mass index. CONCLUSIONS: The ModSNAQ is validated against dietary intake and offers a structured approach to appetite assessment. Using this tool, low appetite is more common than previously reported in CKD and does not correlate with degree of renal impairment. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Harmer, Matthew J AU - Harmer MJ AD - Southampton Children's Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre-Nutrition, University Hospital Southampton NHS Foundation Trust, Southampton, UK. Electronic address: matthew.harmer@uhs.nhs.uk. FAU - Wootton, Steve AU - Wootton S AD - Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre-Nutrition, University Hospital Southampton NHS Foundation Trust, Southampton, UK. FAU - Gilbert, Rodney D AU - Gilbert RD AD - Southampton Children's Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine, University of Southampton, Southampton, UK. FAU - Anderson, Caroline AU - Anderson C AD - Southampton Children's Hospital, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Faculty of Medicine, University of Southampton, Southampton, UK; NIHR Southampton Biomedical Research Centre-Nutrition, University Hospital Southampton NHS Foundation Trust, Southampton, UK; Department of Nutrition and Dietetics, University Hospital Southampton NHS Foundation Trust, Southampton, UK. LA - eng PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20260203 PL - United States TA - J Ren Nutr JT - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JID - 9112938 SB - IM MH - Adolescent MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - *Appetite/physiology MH - Body Mass Index MH - Cross-Sectional Studies MH - Energy Intake MH - Glomerular Filtration Rate MH - *Nutrition Assessment MH - *Renal Insufficiency, Chronic/physiopathology/complications MH - Reproducibility of Results OTO - NOTNLM OT - CKD OT - appetite OT - assessment tool OT - children EDAT- 2026/02/06 00:30 MHDA- 2026/09/25 23:47 CRDT- 2026/02/05 19:18 PHST- 2024/09/09 00:00 [received] PHST- 2025/11/30 00:00 [revised] PHST- 2026/01/23 00:00 [accepted] PHST- 2026/09/25 23:47 [medline] PHST- 2026/02/06 00:30 [pubmed] PHST- 2026/02/05 19:18 [entrez] AID - S1051-2276(26)00012-9 [pii] AID - 10.1053/j.jrn.2026.01.003 [doi] PST - ppublish SO - J Ren Nutr. 2026 Sep;36(5):725-729. doi: 10.1053/j.jrn.2026.01.003. Epub 2026 Feb 3. PMID- 41643799 OWN - NLM STAT- MEDLINE DCOM- 20260821 LR - 20260821 IS - 1542-7714 (Electronic) IS - 1542-3565 (Print) IS - 1542-3565 (Linking) VI - 24 IP - 9 DP - 2026 Sep TI - Prediction of Inflammatory Bowel Disease Based on Early Life Risk Factors in a Population-Based Cohort. PG - 2551-2559 LID - S1542-3565(26)00063-7 [pii] LID - 10.1016/j.cgh.2026.01.034 [doi] AB - BACKGROUND & AIMS: Although many early life exposures have been associated with inflammatory bowel disease (IBD), prediction of risk based on these variables is not yet available. METHODS: We conducted a nationwide population-based cohort study including offspring in the Danish National Birth Cohort with available interview data at 4 time points on early life exposures. Follow-up continued until IBD diagnoses, emigration, death, or end of the study period (September 1, 2022). We used elastic net with underlying Cox regression model to predict IBD diagnosis at <13 and <17 years of age and for the duration of follow-up. We used the entire dataset for model development and internal validation with optimism correction in the fit metrics by bootstrapping. RESULTS: A total of 50,592 offspring were included in the study. During a median follow-up of 21.8 years (interquartile range, 20.4-22.9 years), 310 offspring (0.6%) developed IBD, including 171 with Crohn's disease (CD) and 139 with ulcerative colitis (UC). The area under the receiver operating characteristic curve (AUC) for prediction of IBD overall, at age <17 years, and at <13 years was 0.56, 0.60, and 0.69, respectively. The best prediction models were for UC with onset at age <17 years and <13 years (AUC, 0.64 and 0.76, respectively). Cumulative incidence rates for each outcome for those in the top 5%, compared with the lower 95% of predicted risk, were between 1.6- and 26-fold higher for each model. The main variables contributing to the models included parental IBD status, hygiene-related variables, and those relating to early life diet and infections. CONCLUSIONS: In a nationwide cohort with long-term follow-up data, early life exposures were predictive of UC, especially younger-onset disease, whereas prediction of CD was less accurate. CI - Copyright (c) 2026 American Gastroenterological Association Institute. Published by Elsevier Inc. All rights reserved. FAU - Agrawal, Manasi AU - Agrawal M AD - The Dr Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Clinical Medicine, Center for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Aalborg University, Copenhagen, Denmark. Electronic address: manasi.agrawal@mountsinai.org. FAU - Hansen, Anne Vinkel AU - Hansen AV AD - The Dr Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York. FAU - Julsgaard, Mette AU - Julsgaard M AD - Department of Clinical Medicine, Center for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Aalborg University, Copenhagen, Denmark; Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark. FAU - Colombel, Jean-Frederic AU - Colombel JF AD - The Dr Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, New York. FAU - Jess, Tine AU - Jess T AD - Department of Clinical Medicine, Center for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Aalborg University, Copenhagen, Denmark; Department of Gastroenterology & Hepatology, Aalborg University Hospital, Aalborg, Denmark. LA - eng GR - K23 DK129762/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20260203 PL - United States TA - Clin Gastroenterol Hepatol JT - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JID - 101160775 SB - IM MH - Humans MH - Denmark/epidemiology MH - Female MH - Risk Factors MH - Adolescent MH - Male MH - Cohort Studies MH - Child MH - *Inflammatory Bowel Diseases/epidemiology/diagnosis MH - Young Adult MH - Adult MH - Risk Assessment MH - Follow-Up Studies MH - Child, Preschool MH - Proportional Hazards Models PMC - PMC12893764 MID - NIHMS2145550 OTO - NOTNLM OT - Early Life OT - Inflammatory Bowel Disease OT - Nationwide OT - Prediction Model COIS- The corresponding author confirms on behalf of all authors that there have been no involvements that might raise the question of bias in the work reported or in the conclusions, implications, or opinions stated. MA reports having received consulting fee from MedScape. AVH reports no conflict of interest. MJ has received a research grant for other investigator-driven studies from Takeda, has been on the advisory board of Eli Lilly, Abbvie, PharmaCosmos and Tillotts Pharma, has received consultation fees from Eli Lilly, Ferring and Takeda, and has received speaker's fees from Tillotts Pharma, MSD, Ferring, and Takeda. JFC reports receiving research grants from AbbVie, Janssen Pharmaceuticals and Takeda; receiving payment for lectures from AbbVie, Amgen, Allergan, Inc. Ferring Pharmaceuticals, Shire, and Takeda; receiving consulting fees from AbbVie, Amgen, Arena Pharmaceuticals, Boehringer Ingelheim, Bristol Myers Squibb, Celgene Corporation, Eli Lilly, Ferring Pharmaceuticals, Galmed Research, Glaxo Smith Kline, Geneva, Iterative Scopes, Janssen Pharmaceuticals, Kaleido Biosciences, Landos, Otsuka, Pfizer, Prometheus, Sanofi, Takeda, TiGenix,; and hold stock options in Intestinal Biotech Development. TJ reports consulting fees from Ferring and Pfizer. EDAT- 2026/02/06 00:30 MHDA- 2026/08/21 23:37 PMCR- 2027/02/03 CRDT- 2026/02/05 19:12 PHST- 2025/07/23 00:00 [received] PHST- 2026/01/16 00:00 [revised] PHST- 2026/01/23 00:00 [accepted] PHST- 2026/08/21 23:37 [medline] PHST- 2026/02/06 00:30 [pubmed] PHST- 2026/02/05 19:12 [entrez] PHST- 2027/02/03 00:00 [pmc-release] AID - S1542-3565(26)00063-7 [pii] AID - 10.1016/j.cgh.2026.01.034 [doi] PST - ppublish SO - Clin Gastroenterol Hepatol. 2026 Sep;24(9):2551-2559. doi: 10.1016/j.cgh.2026.01.034. Epub 2026 Feb 3. PMID- 41643714 OWN - NLM STAT- MEDLINE DCOM- 20260729 LR - 20260916 IS - 1098-8785 (Electronic) IS - 0735-1631 (Linking) VI - 43 IP - 11 DP - 2026 Aug TI - Cue-Based and Volume-Based Oral Feeding Progression Strategies and Outcomes in Extremely Premature Infants. PG - 1539-1545 LID - 10.1055/a-2796-1524 [doi] AB - OBJECTIVE: This study aimed to compare the feeding outcomes of extremely premature infants (EPI, <28 weeks' gestational age) cared for by the same neonatology group at two tertiary neonatal intensive care units that employed two different oral feeding strategies (cue-based oral feeding progression [CB-OFP] and volume-based oral feeding progression [VB-OFP]). STUDY DESIGN: We conducted a retrospective cohort study of EPI (July 1, 2022, and April 12, 2024) patients discharged on full oral feedings. The primary outcome was postmenstrual age (PMA) when full oral feeding was achieved. Secondary outcomes included time to full oral feeds, PMA and weight at initiation and discharge, growth velocity, and length of hospital stay. RESULTS: Baseline characteristics were similar among 119 EPIs (CB-OFP: n = 61; VB-OFP: n = 58) except for maternal magnesium sulfate exposure and postnatal steroid use. CB-OFP infants achieved full oral feeding at an earlier PMA (median: 37.6 vs. 40.1 weeks; p < 0.001) and in fewer median days (20 vs. 27 days; p = 0.03). CB-OFP was also associated with earlier discharge (median PMA at discharge: 38.6 vs. 41.3 weeks; p < 0.001) and shorter length of stay (93 vs. 111.5 days; p < 0.001). Growth velocity and discharge weight z-scores did not differ significantly between groups. CONCLUSION: Our experience suggests that a CB-OFP strategy may be associated with earlier attainment of full oral feeds and a shorter length of stay compared with VB-OFP. Future randomized controlled trials are warranted to validate these findings and to assess potential long-term neurodevelopmental outcomes with different feeding strategies. KEY POINTS: . There is no consensus on the optimal oral feeding progression strategy for EPIs.. . A CB-OFP strategy was associated with earlier achievement of full oral feeding and a shorter length of stay.. . Oral motor interventions, including stimulation exercises, may play a role in improving oral feeding abilities in EPIs.. CI - Thieme. All rights reserved. FAU - Diaz, Mariana AU - Diaz M AD - Department of Pediatrics, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, United States. FAU - Nandula, Padma AU - Nandula P AD - Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, United States. FAU - Kumar, Vasantha H S AU - Kumar VHS AD - Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, United States. FAU - Gautam, Shiva AU - Gautam S AD - Department of Biostatistics, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, United States. FAU - Hudak, Mark L AU - Hudak ML AD - Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, United States. FAU - Shah, Sanket D AU - Shah SD AUID- ORCID: 0000-0002-1033-0156 AD - Division of Neonatology, Department of Pediatrics, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, United States. LA - eng PT - Journal Article DEP - 20260205 PL - United States TA - Am J Perinatol JT - American journal of perinatology JID - 8405212 SB - IM MH - Humans MH - Retrospective Studies MH - *Infant, Extremely Premature/growth & development MH - Female MH - Infant, Newborn MH - Male MH - Gestational Age MH - Length of Stay MH - Intensive Care Units, Neonatal MH - *Enteral Nutrition/methods COIS- The authors declare that they have no conflict of interest. EDAT- 2026/02/06 00:30 MHDA- 2026/07/29 18:38 CRDT- 2026/02/05 18:52 PHST- 2026/07/29 18:38 [medline] PHST- 2026/02/06 00:30 [pubmed] PHST- 2026/02/05 18:52 [entrez] AID - 10.1055/a-2796-1524 [doi] PST - ppublish SO - Am J Perinatol. 2026 Aug;43(11):1539-1545. doi: 10.1055/a-2796-1524. Epub 2026 Feb 5. PMID- 41643687 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2214-109X (Electronic) IS - 2214-109X (Linking) VI - 14 IP - 5 DP - 2026 May TI - Impact of two decades of humanitarian and development assistance and the projected mortality consequences of current defunding to 2030: retrospective evaluation and forecasting analysis. PG - e690-e701 LID - S2214-109X(26)00008-2 [pii] LID - 10.1016/S2214-109X(26)00008-2 [doi] AB - BACKGROUND: Official development assistance (ODA) accounts for the majority of humanitarian and development assistance in the world's most vulnerable countries and has played a pivotal role in advancing global health. We aimed to comprehensively evaluate the impact of ODA funding on mortality across the past two decades, and to project the potential consequences of current defunding trends. METHODS: We conducted an integrated retrospective evaluation and forecasting analysis using longitudinal panel data from 93 low-income and middle-income countries (LMICs). First, we estimated the association between ODA per-capita funding and mortality outcomes from 2002 to 2021 using a two-ways fixed-effects multivariable Poisson regression model with robust standard errors, adjusted for all relevant demographic, socioeconomic, and health-system covariates. We then assessed age-specific and cause-specific effects, performing extensive sensitivity and triangulation analyses to test the robustness and causal interpretation of results. Finally, we integrated the retrospective impact estimates into validated country-level microsimulation models to forecast mortality under three defunding scenarios up to 2030: a business-as-usual trajectory, a severe defunding scenario, and a mild defunding scenario. FINDINGS: Higher ODA funding levels were associated with a 23% reduction in age-standardised all-cause mortality (rate ratio [RR] 0.77; 95% CI 0.70-0.85) and a 39% reduction in under-5 mortality (0.61; 0.49-0.75). ODA funding was associated with large mortality declines in major communicable diseases: 70% for HIV/AIDS (RR 0.30; 95% CI 0.24-0.39), 56% for malaria (0.44; 0.35-0.56), 56% for nutritional deficiencies (0.44; 0.30-0.65), and 54% for neglected tropical diseases (0.46; 0.36-0.59). Significant reductions were also observed in mortality from tuberculosis, diarrhoeal diseases, lower respiratory infections, and maternal and perinatal causes. Forecasting analyses projected that ongoing reductions in ODA funding could, under a severe defunding scenario, result in 22.6 million (95% uncertainty interval [UI] 16.3-29.3) additional deaths across all ages by 2030, including 5.4 million (4.1-6.8) among children younger than 5 years. Under a mild defunding scenario-defined as a continuation of current downward trends-the projected excess deaths would be 9.4 million (95% UI 6.2-12.6) overall and 2.5 million (1.8-3.2) among children younger than 5 years. INTERPRETATION: ODA funding has played a decisive role in reducing preventable mortality across LMICs over the past two decades, and the abrupt withdrawal of this support threatens to cause millions of avoidable deaths, reversing decades of progress in global health. FUNDING: RF Catalytic Capital and the Spanish Ministry of Science and Innovation. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved. FAU - da Silva, Andrea Ferreira AU - da Silva AF AD - Institute of Collective Health, Federal University of Bahia, Bahia, Brazil; Universidade Regional do Cariri - URCA, Cariri, Brazil. FAU - Anderle, Rodrigo Volmir Rezende AU - Anderle RVR AD - Institute of Collective Health, Federal University of Bahia, Bahia, Brazil. FAU - Sibils, Gonzalo Barreix AU - Sibils GB AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain; Facultat de Medicina i Ciencies de la Salut, Universitat de Barcelona, Barcelona, Spain. FAU - de Oliveira Ferreira de Sales, Lucas AU - de Oliveira Ferreira de Sales L AD - Institute of Collective Health, Federal University of Bahia, Bahia, Brazil. FAU - Pena, Daiana AU - Pena D AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. FAU - Monti, Caterina AU - Monti C AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain; Facultat de Medicina i Ciencies de la Salut, Universitat de Barcelona, Barcelona, Spain. FAU - Vaz, Claudia Garcia AU - Vaz CG AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain; Facultat de Medicina i Ciencies de la Salut, Universitat de Barcelona, Barcelona, Spain. FAU - Santa-Ramirez, Hugo-Alejandro AU - Santa-Ramirez HA AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain. FAU - Dos Santos de Jesus, Gabriela AU - Dos Santos de Jesus G AD - Institute of Collective Health, Federal University of Bahia, Bahia, Brazil. FAU - Cavalcanti, Daniella Medeiros AU - Cavalcanti DM AD - Institute of Collective Health, Federal University of Bahia, Bahia, Brazil. FAU - Nhacolo, Ariel AU - Nhacolo A AD - Centro de Investigacao em Saude de Manhica, Maputo, Mozambique. FAU - Macicame, Ivalda AU - Macicame I AD - Instituto Nacional de Saude, Mozambique. FAU - Bassat, Quique AU - Bassat Q AD - Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain; Facultat de Medicina i Ciencies de la Salut, Universitat de Barcelona, Barcelona, Spain; Centro de Investigacao em Saude de Manhica, Maputo, Mozambique; ICREA, Barcelona, Spain; Institut Clinic de Medicina I Dermatologia, Hospital Clinic de Barcelona, Barcelona, Spain; Pediatrics Department, Hospital Sant Joan de Deu, Universitat de Barcelona, Esplugues, Barcelona, Spain; CIBER de Epidemiologia y Salud Publica, Instituto de Salud Carlos III, Madrid, Spain. FAU - Rasella, Davide AU - Rasella D AD - Institute of Collective Health, Federal University of Bahia, Bahia, Brazil; Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain; Facultat de Medicina i Ciencies de la Salut, Universitat de Barcelona, Barcelona, Spain; ICREA, Barcelona, Spain. Electronic address: davide.rasella@isglobal.org. LA - eng PT - Journal Article DEP - 20260202 PL - England TA - Lancet Glob Health JT - The Lancet. Global health JID - 101613665 SB - IM MH - Humans MH - Retrospective Studies MH - Forecasting MH - *Mortality/trends MH - *Developing Countries MH - *Altruism MH - *Global Health COIS- Declaration of interests We declare no competing interests. EDAT- 2026/02/06 00:31 MHDA- 2026/04/27 00:30 CRDT- 2026/02/05 18:52 PHST- 2025/11/17 00:00 [received] PHST- 2025/12/23 00:00 [revised] PHST- 2026/01/09 00:00 [accepted] PHST- 2026/04/27 00:30 [medline] PHST- 2026/02/06 00:31 [pubmed] PHST- 2026/02/05 18:52 [entrez] AID - S2214-109X(26)00008-2 [pii] AID - 10.1016/S2214-109X(26)00008-2 [doi] PST - ppublish SO - Lancet Glob Health. 2026 May;14(5):e690-e701. doi: 10.1016/S2214-109X(26)00008-2. Epub 2026 Feb 2. PMID- 41643121 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260819 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Feb 5 TI - Family-Based Digital Lifestyle Intervention for Hispanic Adolescents and Their Parents: Iterative Co-Design and Development Study. PG - e73848 LID - 10.2196/73848 [doi] LID - e73848 AB - BACKGROUND: Hispanic youth in the United States have the highest rates of pediatric obesity and do not often meet national guidelines for physical activity and dietary intake. Family-based interventions can improve health outcomes in both youth and their parents and are highly relevant to Hispanics due to the cultural value of familismo (familism). However, few existing family-based obesity prevention interventions for Hispanics target adolescents and their parents, and those that do are not designed to facilitate widespread reach. OBJECTIVE: This study describes the development of Healthy Juntos (Healthy Together), a family-based intervention for Hispanic adolescents and their parents that leverages the web and smartphone technology to prevent the onset of adolescent obesity by promoting healthy lifestyle behaviors (physical activity and diet). METHODS: We used an iterative co-design process guided by the Integrate, Design, Assess, and Share (IDEAS) framework, which outlines 10 phases for developing digital interventions. Hispanic adolescents at risk for obesity and their parents (n=90; 45 dyads) participated across different phases of the intervention development process. We conducted qualitative interviews to understand their needs and preferences and to gather feedback on a series of intervention prototypes (conceptual, paper and minimally functional, and fully functional). RESULTS: Participants reported using technology for their health in limited ways (eg, to search for medical symptoms and recipes). They described the importance of having interactive and social features as part of a family-based digital health intervention. Their suggestions related to content, functionality, and aesthetics resulted in a fully functional prototype of a digital lifestyle intervention for Hispanic adolescents and their parents. CONCLUSIONS: The iterative co-design process was crucial for refining the Healthy Juntos intervention. Our next steps are to evaluate its feasibility, acceptability, and preliminary effects through a pilot randomized controlled trial. CI - (c) Sara Mijares St George, Blanca S Noriega Esquives, Rafael Leite, Vanina Pavia Aubry, Rana Saber, Yaray Agosto, Marissa Kobayashi, Guillermo Prado. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - St George, Sara Mijares AU - St George SM AUID- ORCID: 0000-0001-7263-4609 AD - Department of Public Health Sciences, University of Miami Miller School of Medicine, 1120 NW 14 Street, Suite 1009, Miami, FL, 33136, United States, 1 305 243 0726. AD - Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States. FAU - Noriega Esquives, Blanca S AU - Noriega Esquives BS AUID- ORCID: 0000-0002-5865-4408 AD - Department of Public Health Sciences, University of Miami Miller School of Medicine, 1120 NW 14 Street, Suite 1009, Miami, FL, 33136, United States, 1 305 243 0726. AD - Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, United States. FAU - Leite, Rafael AU - Leite R AUID- ORCID: 0000-0002-5597-2347 AD - Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, RI, United States. AD - Weight Control and Diabetes Research Center, The Miriam Hospital, Providence, RI, United States. FAU - Pavia Aubry, Vanina AU - Pavia Aubry V AUID- ORCID: 0000-0002-4593-2202 AD - Department of Public Health Sciences, University of Miami Miller School of Medicine, 1120 NW 14 Street, Suite 1009, Miami, FL, 33136, United States, 1 305 243 0726. FAU - Saber, Rana AU - Saber R AUID- ORCID: 0000-0002-2131-643X AD - Valorous Health Innovation, LLC, Seattle, WA, United States. AD - Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States. FAU - Agosto, Yaray AU - Agosto Y AUID- ORCID: 0000-0002-6422-4674 AD - Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL, United States. FAU - Kobayashi, Marissa AU - Kobayashi M AUID- ORCID: 0000-0001-7475-0785 AD - Department of Psychology, University of Miami, Coral Gables, FL, United States. FAU - Prado, Guillermo AU - Prado G AUID- ORCID: 0000-0002-9164-4244 AD - School of Nursing and Health Studies, University of Miami, Coral Gables, FL, United States. LA - eng GR - K01 HL133521/HL/NHLBI NIH HHS/United States GR - P30 CA240139/CA/NCI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260205 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Adolescent MH - *Hispanic or Latino/psychology/statistics & numerical data MH - Female MH - *Parents/psychology MH - Male MH - Qualitative Research MH - Digital Health MH - Pediatric Obesity/prevention & control MH - *Healthy Lifestyle MH - Life Style MH - *Health Promotion/methods MH - United States PMC - PMC12875426 OTO - NOTNLM OT - Hispanic OT - adolescent OT - digital health OT - family-based OT - obesity prevention OT - user-centered design COIS- Conflicts of Interest: None declared. EDAT- 2026/02/05 19:05 MHDA- 2026/02/05 19:06 PMCR- 2026/02/05 CRDT- 2026/02/05 15:23 PHST- 2025/03/31 00:00 [received] PHST- 2025/12/12 00:00 [revised] PHST- 2025/12/15 00:00 [accepted] PHST- 2026/02/05 19:06 [medline] PHST- 2026/02/05 19:05 [pubmed] PHST- 2026/02/05 15:23 [entrez] PHST- 2026/02/05 00:00 [pmc-release] AID - v10i1e73848 [pii] AID - 73848 [pii] AID - 10.2196/73848 [doi] PST - epublish SO - JMIR Form Res. 2026 Feb 5;10:e73848. doi: 10.2196/73848. PMID- 41642415 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260713 IS - 1862-3514 (Electronic) VI - 21 IP - 1 DP - 2026 Feb 5 TI - Knowledge of osteoporosis prevention among health science students in North Africa: a descriptive correlational cross-sectional study. PG - 32 LID - 10.1007/s11657-026-01662-4 [doi] AB - This study aimed to describe the level of knowledge about osteoporosis prevention among health science students and to identify influencing factors. Results show a low level of knowledge regarding osteoporosis 13.27 +/- 3.67 out of 32. Also influencing factors were such as gender (p = 0.007), age (p = 0.003), living environment (p = 0.009) and educational level (p = 0.017). PURPOSE: The Purpose of this study was to describe the level of knowledge about osteoporosis prevention among health science students and to identify influencing factors. METHODS: A descriptive correlational study was conducted among 524 health science students enrolled at the Higher School of Health Sciences and Techniques of Sousse (HSHSTS) and the Higher Institute of Nursing Sciences of Sousse (HINSS), Tunisia. Data were collected using a validated, self-administered questionnaire based on the revised Osteoporosis Knowledge Test (OKT). The OKT included two subscales assessing knowledge of osteoporosis prevention through physical activity and nutrition. Each correct response was awarded one point, while incorrect or "unknown" answers received zero points. The questionnaire also gathered sociodemographic information, including gender, age, living environment, and educational level. RESULTS: The participants had a mean age of 20.5 +/- 1.4 years. Overall, 71.8% of students demonstrated a low level of knowledge regarding osteoporosis. The mean total knowledge score was 13.27 +/- 3.67 out of 32. Female students scored significantly higher on the overall OKT compared to males (p = 0.007). Physical activity subscale scores were significantly associated with gender (p = 0.005), age (p = 0.003), living environment (p = 0.009), and education level (p = 0.010). Similarly, nutrition-related knowledge showed significant associations with gender (p < 0.001), age (p = 0.001), living environment (p = 0.033), and education level (p = 0.002). CONCLUSION: Key limitations include the cross-sectional design, possible participation bias from differing response rates between institutions, and a markedly imbalanced sex ratio, which may limit generalizability. These findings highlight the need for targeted educational interventions and early integration of osteoporosis content into university curricula to improve knowledge. CI - (c) 2026. The Author(s), under exclusive licence to the International Osteoporosis Foundation and the Bone Health and Osteoporosis Foundation. FAU - Belgacem, Amina AU - Belgacem A AUID- ORCID: 0000-0002-0449-631X AD - University of Sousse, Higher School of Health Sciences and Techniques of Sousse, Street TAJIKISTAN Sahloul II, 4054, Sousse, Tunisia. aminabelgacem04@gmail.com. FAU - Chbili, Chahra AU - Chbili C AD - University of Sousse, Higher School of Health Sciences and Techniques of Sousse, Street TAJIKISTAN Sahloul II, 4054, Sousse, Tunisia. AD - 2Metabolic Biophysics and Applied Pharmacology Laboratory, Faculty of Medicine of Sousse, Sousse University, Sousse, Tunisia. FAU - Maitigue, Mahmoud Ben AU - Maitigue MB AD - Department of Orthopedic. Surgery, University Hospital Sahloul Route Ceinture Cited Sahloul, 4054, Sousse, Tunisia. FAU - Brahem, Hamza AU - Brahem H AD - University of Sousse, Higher School of Health Sciences and Techniques of Sousse, Street TAJIKISTAN Sahloul II, 4054, Sousse, Tunisia. FAU - Brahem, Acil AU - Brahem A AD - University of Sousse, Higher School of Health Sciences and Techniques of Sousse, Street TAJIKISTAN Sahloul II, 4054, Sousse, Tunisia. FAU - Charfeddine, Bassem AU - Charfeddine B AD - University of Sousse, Higher School of Health Sciences and Techniques of Sousse, Street TAJIKISTAN Sahloul II, 4054, Sousse, Tunisia. FAU - Soussi, Sonia AU - Soussi S AUID- ORCID: 0009-0007-4168-4030 AD - University of Tunis El Manar, Higher School of Health Sciences and Techniques of Tunis, La Rabta-Bab Saadoun, B.P. 176-1007, Tunis, Tunisia. LA - eng PT - Journal Article DEP - 20260205 PL - England TA - Arch Osteoporos JT - Archives of osteoporosis JID - 101318988 SB - IM MH - Humans MH - Female MH - Male MH - Cross-Sectional Studies MH - *Osteoporosis/prevention & control MH - *Health Knowledge, Attitudes, Practice MH - Surveys and Questionnaires MH - Young Adult MH - Tunisia MH - Adult MH - *Students MH - Adolescent OTO - NOTNLM OT - Calcium intake OT - Health science students OT - Knowledge OT - Osteoporosis prevention OT - Physical activity COIS- Declarations. Ethics approval: All procedures performed in study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study has been approved by the appropriate institutional and/or national research ethics committee (Ethic Committee of Faculty of Medicine of Sousse). Informed consent: Informed consent was obtained from all individual participants included in the study. Conflicts of interest: None. EDAT- 2026/02/05 19:05 MHDA- 2026/02/05 19:06 CRDT- 2026/02/05 12:05 PHST- 2025/05/20 00:00 [received] PHST- 2026/01/20 00:00 [accepted] PHST- 2026/02/05 19:06 [medline] PHST- 2026/02/05 19:05 [pubmed] PHST- 2026/02/05 12:05 [entrez] AID - 10.1007/s11657-026-01662-4 [pii] AID - 10.1007/s11657-026-01662-4 [doi] PST - epublish SO - Arch Osteoporos. 2026 Feb 5;21(1):32. doi: 10.1007/s11657-026-01662-4. PMID- 41641667 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260927 IS - 2047-6310 (Electronic) IS - 2047-6302 (Print) IS - 2047-6302 (Linking) VI - 21 IP - 2 DP - 2026 Feb TI - Household Food Insecurity Is Associated With Higher Adiposity Over Time Among Adolescents in Louisiana. PG - e70084 LID - 10.1111/ijpo.70084 [doi] LID - e70084 AB - BACKGROUND: Few studies have examined how household food insecurity may impact longitudinal changes in adiposity among adolescents. OBJECTIVE: We investigated the link between household food insecurity and 2-year change in adolescent adiposity, with sex as a potential moderator. METHODS: Analyses included 222 adolescents living in and around Baton Rouge, Louisiana, who participated in the TIGER Kids study (baseline: June 2016-December 2017; follow-up: January 2018-August 2019). Household food security was measured using a validated two-question parent-reported survey. Adiposity outcomes were collected using anthropometry, dual-energy X-ray absorptiometry and abdominal magnetic resonance imaging (MRI). Multivariable multilevel models assessed associations between household food security and changes in adiposity. RESULTS: At baseline, the participants were 12.9 +/- 1.9 years, 50.5% female, 37.4% non-White or Hispanic, 31.5% had obesity, and 11.3% were food insecure. Food-insecure adolescents exhibited significantly greater increases in BMI(p95) (b = 6.0% +/- 2.2%, p = 0.0082), waist circumference (b = 4.1 +/- 1.7 cm, p = 0.0158), total body fat percentage (b = 3.0% +/- 1.3%, p = 0.0194) and visceral adipose tissue mass (b = 0.16 +/- 0.06 kg, p = 0.0163), compared to their food-secure peers. The effect of food insecurity on adiposity did not differ between boys and girls. CONCLUSIONS: This longitudinal study highlights the deleterious influence of food insecurity on adolescent adiposity. Efforts to alleviate food insecurity may play an important role in preventing obesity in adolescents. CI - (c) 2026 The Author(s). Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation. FAU - Fenton, Ashley AU - Fenton A AUID- ORCID: 0009-0002-9519-8613 AD - School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. FAU - Staiano, Amanda E AU - Staiano AE AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. FAU - Celestin, Michael AU - Celestin M AD - School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. FAU - Ferguson, Tekeda AU - Ferguson T AD - School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. FAU - Myers, Candice A AU - Myers CA AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. FAU - Tseng, Tung-Sung AU - Tseng TS AD - School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. FAU - Broyles, Stephanie T AU - Broyles ST AD - School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA. AD - Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA. LA - eng GR - NCT02784509/ClinicalTrials.gov/ GR - U54 GM104940/NH/NIH HHS/United States GR - P30 DK072476/DK/NIDDK NIH HHS/United States GR - 3092-51000-056-04A/United States Department of Agriculture/ GR - U54 GM104940/GM/NIGMS NIH HHS/United States GR - P30DK072476/NH/NIH HHS/United States PT - Journal Article PL - England TA - Pediatr Obes JT - Pediatric obesity JID - 101572033 SB - IM MH - Humans MH - Female MH - Male MH - Louisiana/epidemiology MH - *Adiposity/physiology MH - Adolescent MH - *Food Insecurity MH - Child MH - Longitudinal Studies MH - *Pediatric Obesity/epidemiology PMC - PMC12874501 OTO - NOTNLM OT - adiposity OT - adolescents OT - food insecurity OT - longitudinal study OT - obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/02/05 17:34 MHDA- 2026/02/05 17:35 PMCR- 2026/02/05 CRDT- 2026/02/05 06:33 PHST- 2025/12/05 00:00 [revised] PHST- 2025/04/04 00:00 [received] PHST- 2026/01/08 00:00 [accepted] PHST- 2026/02/05 17:35 [medline] PHST- 2026/02/05 17:34 [pubmed] PHST- 2026/02/05 06:33 [entrez] PHST- 2026/02/05 00:00 [pmc-release] AID - IJPO70084 [pii] AID - 10.1111/ijpo.70084 [doi] PST - ppublish SO - Pediatr Obes. 2026 Feb;21(2):e70084. doi: 10.1111/ijpo.70084. PMID- 41641503 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260921 IS - 1461-7005 (Electronic) IS - 1362-3613 (Print) IS - 1362-3613 (Linking) VI - 30 IP - 3 DP - 2026 Mar TI - Sleep and activity patterns in autism. PG - 767-787 LID - 10.1177/13623613251413538 [doi] AB - Autism is a heritable neurodevelopmental condition marked by impaired social interaction, repetitive behavior, and co-occurring conditions. Sleep disturbances are common in autism. This study uses low-cost wearable devices to compare sleep, physical activity, and circadian behavior in autistic adults and their non-autistic relatives. We recruited 318 autistic individuals and 130 family members, collecting accelerometer data over 3 weeks (8249 days). Using a data-driven approach, we identified actimetry-derived features associated with autism. We examined 308 traits using the elastic net algorithm and linear mixed effects regressions. We identified 52 actimetry measures associated with autism (area under the curve: 0.812; confidence interval: 0.761-0.862), validated in a test set (area under the curve: 0.756; confidence interval: 0.700-0.813). Both mean and day-to-day variability in several measures (e.g., time spent sedentary, total light physical activity) were associated with autism. In autistic individuals, reduced physical activity during wake was more strongly associated with shorter sleep time than in non-autistic relatives (likelihood ratio: 41.6; p = 1.13e-10). Reduced physical activity in autistic individuals was linked to increased social impairment, as measured by the Social Responsiveness Scale. Long inactivity periods and lower physical activity levels were associated with autism, correlating with less sleep and later sleep onset. Interventional studies are needed to explore if improving sleep and physical activity can improve the quality of life for autistic individuals.Lay AbstractAutistic individuals frequently report problems with their sleep, though what aspects of sleep are most affected is not well understood. In this study, we recruited 318 adult autistic participants without intellectual disability and 130 of their non-autistic family members to measure their sleep, physical activity, and daily routines. Study participants wore accelerometer-based wrist-worn devices over 3 consecutive weeks to record their movement and activity. In total, 154 distinct physical activity, sleep, and behavioral traits were identified from the recordings, 52 of which were found to associate with autism. Many of these traits were related to physical activity, where autistic individuals were more likely to be less active for longer periods and have lower overall physical activity levels. Long periods of inactivity also associated with less sleep, with a stronger association in those with autism. For example, for every hour of inactivity, autistic participants had on average ~23 min less of sleep compared to ~17 min in their family members. Autistic individuals with lower levels of physical activity showed higher social impairment as measured by the Social Responsiveness Scale. Overall, lower physical activity may impair sleep and worsen the core features of autism. Interventional studies aimed to increase physical activity may improve the quality of life of autistic individuals. FAU - Weissenkampen, J Dylan AU - Weissenkampen JD AUID- ORCID: 0000-0003-1928-5184 AD - University of Pennsylvania, USA. FAU - Ghorai, Arpita AU - Ghorai A AD - University of Pennsylvania, USA. FAU - Carneiro, Thaise Nr AU - Carneiro TN AD - University of Pennsylvania, USA. FAU - Fasolino, Maria AU - Fasolino M AD - University of Pennsylvania, USA. FAU - Gehringer, Brielle N AU - Gehringer BN AUID- ORCID: 0000-0002-5737-6610 AD - University of Pennsylvania, USA. FAU - Rajan, Maya AU - Rajan M AD - University of Pennsylvania, USA. FAU - Dow, Holly C AU - Dow HC AUID- ORCID: 0000-0002-7718-4261 AD - University of Pennsylvania, USA. FAU - Kunatharaju, Shriya AU - Kunatharaju S AD - University of Pennsylvania, USA. FAU - Roenneberg, Till AU - Roenneberg T AD - Ludwig-Maximilians-University Munich, Germany. FAU - Sebro, Ronnie AU - Sebro R AD - Mayo Clinic, USA. FAU - Rader, Daniel J AU - Rader DJ AD - University of Pennsylvania, USA. FAU - Keenan, Brendan T AU - Keenan BT AD - University of Pennsylvania, USA. FAU - Almasy, Laura AU - Almasy L AD - University of Pennsylvania, USA. AD - Children's Hospital of Philadelphia, USA. FAU - Brodkin, Edward S AU - Brodkin ES AUID- ORCID: 0000-0003-1417-7838 AD - University of Pennsylvania, USA. FAU - Bucan, Maja AU - Bucan M AUID- ORCID: 0000-0002-5684-1736 AD - University of Pennsylvania, USA. LA - eng GR - P30 ES013508/ES/NIEHS NIH HHS/United States GR - R01 MH093415/MH/NIMH NIH HHS/United States GR - T32 ES019851/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20260205 PL - England TA - Autism JT - Autism : the international journal of research and practice JID - 9713494 SB - IM UOF - bioRxiv. 2024 May 07:2024.05.02.592263. doi: 10.1101/2024.05.02.592263. PMID: 38766266 MH - Humans MH - Male MH - Female MH - Adult MH - *Autistic Disorder/physiopathology/complications MH - *Exercise/physiology MH - Sleep Duration MH - *Sleep/physiology MH - Young Adult MH - Middle Aged MH - Circadian Rhythm MH - Accelerometry MH - *Sleep Wake Disorders/physiopathology MH - Actigraphy MH - Adolescent PMC - PMC12923632 OTO - NOTNLM OT - actimetry OT - autism OT - circadian behavior OT - physical activity OT - sleep COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/02/05 06:31 MHDA- 2026/02/25 10:21 PMCR- 2026/02/21 CRDT- 2026/02/05 04:47 PHST- 2026/02/25 10:21 [medline] PHST- 2026/02/05 06:31 [pubmed] PHST- 2026/02/05 04:47 [entrez] PHST- 2026/02/21 00:00 [pmc-release] AID - 10.1177_13623613251413538 [pii] AID - 10.1177/13623613251413538 [doi] PST - ppublish SO - Autism. 2026 Mar;30(3):767-787. doi: 10.1177/13623613251413538. Epub 2026 Feb 5. PMID- 41640849 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 14 DP - 2026 TI - Plant-based protein consumption patterns among Saudi Generation Z: a cross-sectional study of dietary frequencies, health outcomes, and sustainable eating behaviors. PG - 1739641 LID - 10.3389/fpubh.2026.1739641 [doi] LID - 1739641 AB - BACKGROUND: The global shift toward sustainable food systems has highlighted plant-based proteins as essential for environmental and health benefits. However, research on plant-based protein consumption among young adults in the Gulf region, particularly in Saudi Arabia, remains limited despite the country's youthful demographic profile and increasing environmental awareness. OBJECTIVE: This cross-sectional study explored plant-based protein consumption patterns frequencies among Saudi Generation Z (Gen Z) aged 18-25, examining associations with health outcomes, sustainable healthy eating behaviors (SHEBs), and readiness to adopt sustainable healthy diets. METHODS: A non-representative convenience sample of 398 Saudi adults was recruited through snowball sampling. Data was collected via an online survey incorporating validated instruments for dietary consumption frequency, SHEB assessment, and stages-of-change measurement. Participants were categorized into three groups based on weekly consumption frequency of plant-based protein sources: low frequency (0-7 portions/week), moderate frequency (8-21 portions/week), and high frequency (>/=22 portions/week). Statistical analyses included analysis of variance, chi-square tests, and binary logistic regression. RESULTS: The median weekly consumption frequency of plant-based protein sources was 14 portions/week (IQR: 7-24), compared to 28 portions/week (IQR: 21-35) for animal-based protein sources. Only 21.4% of participants achieved high consumption frequency (>/=22 portions/week). Higher plant-based protein consumption frequency was associated with lower mean body mass index (BMI) (23.19 +/- 6.58 vs. 24.57 +/- 7.02 kg/m(2) among low-frequency consumers, p = 0.031), greater engagement in SHEBs (mean score: 2.17 +/- 0.43 vs. 1.91 +/- 0.38, p < 0.001), and more advanced stages of change toward adopting plant-based diets (p < 0.001). Health motivations predominated across all groups (>35%), while environmental concerns remained minimal (4.9-7.1%). The majority of participants (83.2%) were in the precontemplation or contemplation stages regarding plant-based diet adoption. CONCLUSION: Plant-based protein consumption among this Saudi Gen Z convenience sample remains markedly lower than animal-based protein intake, indicating limited integration of legumes, nuts, and plant-based alternatives into routine diets. Higher consumption frequency was observed alongside lower BMI and greater engagement in sustainable eating behaviors, suggesting associations that warrant further study. However, the cross-sectional design limits causal interpretation, and consumption frequency reflects behavioral patterns rather than validated nutritional intake or adequacy. Promoting health benefits while respecting traditional food practices may support healthier dietary shifts among young Arabs. CI - Copyright (c) 2026 Al-Otaibi and Al-Hashim. FAU - Al-Otaibi, Hala Hazam AU - Al-Otaibi HH AD - Department of Food and Nutrition Science, College of Agricultural and Food Science, King Faisal University, Al-Ahsa, Saudi Arabia. FAU - Al-Hashim, Sawsan AU - Al-Hashim S AD - Department of Clinical Nutrition, College of Applied Medical Sciences, King Faisal University, Al-Ahsa, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260120 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 0 (Plant Proteins) SB - IM MH - Humans MH - Saudi Arabia MH - Cross-Sectional Studies MH - Male MH - Female MH - Young Adult MH - Adult MH - *Feeding Behavior MH - Adolescent MH - *Diet, Healthy/statistics & numerical data MH - Diet, Plant-Based MH - *Plant Proteins PMC - PMC12864068 OTO - NOTNLM OT - Arab region OT - Generation Z OT - Saudi Arabia OT - dietary transition OT - environmental awareness OT - gulf countries OT - plant-based protein OT - sustainable healthy diets COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/05 06:32 MHDA- 2026/02/05 06:33 PMCR- 2026/01/20 CRDT- 2026/02/05 04:37 PHST- 2025/11/04 00:00 [received] PHST- 2025/12/24 00:00 [revised] PHST- 2026/01/09 00:00 [accepted] PHST- 2026/02/05 06:33 [medline] PHST- 2026/02/05 06:32 [pubmed] PHST- 2026/02/05 04:37 [entrez] PHST- 2026/01/20 00:00 [pmc-release] AID - 10.3389/fpubh.2026.1739641 [doi] PST - epublish SO - Front Public Health. 2026 Jan 20;14:1739641. doi: 10.3389/fpubh.2026.1739641. eCollection 2026. PMID- 41640515 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260205 LR - 20260207 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 13 DP - 2026 TI - Factors influencing delayed lactogenesis II among advanced-age women following cesarean section: a retrospective analysis and predictive model development. PG - 1733012 LID - 10.3389/fmed.2026.1733012 [doi] LID - 1733012 AB - BACKGROUND: Delayed lactogenesis II (DLII), defined as the onset of copious milk secretion after 72 h postpartum, is a common complication that may impair early breastfeeding success. Advanced maternal age and cesarean delivery are both known risk factors, yet few studies have developed predictive models to identify high-risk women. This study aimed to construct and internally validate a clinical prediction model for DLII among advanced-age women undergoing cesarean section. METHODS: This retrospective observational study analyzed the medical records of 325 women aged >/=35 years who underwent cesarean delivery at a tertiary maternal and child health hospital in Southwest China between January 2021 and January 2025. Maternal, obstetric, surgical, and neonatal variables were extracted from electronic medical records. Univariate and multivariate logistic regression analyses were performed to identify independent predictors of DLII, and a nomogram was subsequently developed. Model discrimination and calibration were assessed using the area under the receiver operating characteristic (ROC) curve (AUC), Hosmer-Lemeshow goodness-of-fit test, and calibration plots with 1,000 bootstrap resamples. RESULTS: Of the 325 women included, 117 (36.0%) experienced DLII. Multivariate analysis identified maternal age (aOR = 1.15, 95% CI 1.01-1.32), pre-pregnancy body mass index (BMI; aOR = 1.10, 95% CI 1.00-1.22), primiparity (aOR = 1.74, 95% CI 1.02-2.96), and shorter gestational age (aOR = 0.71, 95% CI 0.55-0.91) as independent risk factors for DLII. In contrast, elective cesarean section and early postpartum practices (rooming-in within 24 h, breastfeeding initiation within 24 h, and early skin-to-skin contact) were associated with lower odds of delayed lactogenesis II after multivariable adjustment (all p < 0.05). The final model demonstrated excellent discrimination (AUC = 0.870, 95% CI 0.830-0.910) and good calibration (Hosmer-Lemeshow chi (2) = 5.60, p = 0.692). CONCLUSION: This study established a reliable and clinically interpretable model for predicting delayed lactogenesis II among advanced-age women undergoing cesarean section. The model showed high accuracy and good internal validity, highlighting the relevance of maternal characteristics and early postpartum behaviors to lactation outcomes. The proposed nomogram may serve as a practical tool for early risk identification and targeted breastfeeding support in clinical settings. CI - Copyright (c) 2026 Chen, Yu, Wang, Hu and Zhang. FAU - Chen, Lei AU - Chen L AD - Department of Obstetrics, Luzhou Maternal and Child Health Hospital, Luzhou, Sichuan, China. FAU - Yu, Xia AU - Yu X AD - Department of Obstetrics, Luzhou Maternal and Child Health Hospital, Luzhou, Sichuan, China. FAU - Wang, Xiangding AU - Wang X AD - Department of Obstetrics, Luzhou Maternal and Child Health Hospital, Luzhou, Sichuan, China. FAU - Hu, Hong AU - Hu H AD - Department of Obstetrics, Luzhou Maternal and Child Health Hospital, Luzhou, Sichuan, China. FAU - Zhang, Lu AU - Zhang L AD - Department of Child Health Care, Luzhou Maternal and Child Health Hospital, Luzhou, Sichuan, China. LA - eng PT - Journal Article DEP - 20260120 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC12864442 OTO - NOTNLM OT - advanced maternal age OT - breastfeeding OT - cesarean section OT - delayed lactogenesis II OT - lactation OT - predictive model COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/05 06:31 MHDA- 2026/02/05 06:32 PMCR- 2026/01/20 CRDT- 2026/02/05 04:28 PHST- 2025/10/27 00:00 [received] PHST- 2026/01/02 00:00 [revised] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/02/05 06:32 [medline] PHST- 2026/02/05 06:31 [pubmed] PHST- 2026/02/05 04:28 [entrez] PHST- 2026/01/20 00:00 [pmc-release] AID - 10.3389/fmed.2026.1733012 [doi] PST - epublish SO - Front Med (Lausanne). 2026 Jan 20;13:1733012. doi: 10.3389/fmed.2026.1733012. eCollection 2026. PMID- 41640112 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 1540-8159 (Electronic) IS - 0147-8389 (Print) IS - 0147-8389 (Linking) VI - 49 IP - 5 DP - 2026 May TI - Technical Feasibility of the RHYTHMIA Mapping System in Pediatric Patients Weighing Less Than 20Kg. PG - 523-530 LID - 10.1111/pace.70151 [doi] AB - BACKGROUND: Catheter ablation in pediatric patients remains technically challenging. The RHYTHMIA high-density mapping system is increasingly used in pediatric electrophysiology; however, procedural experience in patients weighing less than 20 kg is limited. METHODS: We retrospectively analyzed 125 pediatric patients who underwent catheter ablation for supraventricular arrhythmias using the RHYTHMIA system. The patients were divided into two groups according to body weight: >/=20 kg group (n = 111) and the <20 kg group (n = 14). The mapping time, number of mapping beats, and mapping electrodes were compared for the right atrium (RA), and left atrium (LA), along with the manual re-annotation points and incidence of complications. RESULTS: A total of 184 maps were analyzed. No significant differences were found in mapping time, accepted beats, and electrograms (RA, >/=20 kg group [n = 104] vs. <20 kg group [n = 11]; mapping time, 13.8 min[10.1-18.3] vs. 17.4 min[9.4-25.3], p = 0.95; accepted beats, 744 beats[548-1095] vs. 953 beats[654-1079], p = 0.57; electrograms, 6871 electrograms[5074-10885] vs. 6650 electrograms[4474-9527], p = 0.30) (LA, >/=20 kg group [n = 62] vs. <20 kg group [n = 7]; mapping time, 11.5 min[8.1-18.3] vs. 14.5 min[8.5-15.4], p = 0.97; accepted beats, 619 beats[354-1007] vs. 512 beats[316-810], p = 0.89; electrograms, 6809 electrograms[4025-10108] vs. 4338 electrograms[3369-8693], p = 0.93). In the RA, <20 kg group required more re-annotations than >/=20 kg group, while no significant differences in complications were observed between the groups. CONCLUSIONS: Use of the RHYTHMIA mapping system in carefully selected pediatric patients weighing less than 20 kg was technically feasible and not associated with major procedural complications. These findings support its cautious use with appropriate case selection and operator vigilance. CI - (c) 2026 The Author(s). Pacing and Clinical Electrophysiology published by Wiley Periodicals LLC. FAU - Sasaki, Wataru AU - Sasaki W AUID- ORCID: 0000-0003-1418-6566 AD - Department of Cardiology, Saitama Medical University International Medical Center, Saitama, Japan. FAU - Nabeshima, Taisuke AU - Nabeshima T AUID- ORCID: 0000-0002-1642-6968 AD - Department of Pediatric Cardiology, Saitama Medical University International Medical Center, Saitama, Japan. FAU - Nagaoka, Kouta AU - Nagaoka K AD - Department of Pediatric Cardiology, Saitama Medical University International Medical Center, Saitama, Japan. FAU - Mori, Hitoshi AU - Mori H AUID- ORCID: 0000-0002-1172-2995 AD - Department of Cardiology, Saitama Medical University International Medical Center, Saitama, Japan. AD - Department of Pediatric Cardiology, Saitama Medical University International Medical Center, Saitama, Japan. FAU - Kudo, Daisuke AU - Kudo D AUID- ORCID: 0000-0002-3347-6772 AD - Department of Cardiology, Saitama Medical University International Medical Center, Saitama, Japan. FAU - Tanaka, Naomichi AU - Tanaka N AD - Department of Cardiology, Saitama Medical University International Medical Center, Saitama, Japan. FAU - Naganuma, Tsukasa AU - Naganuma T AD - Department of Cardiology, Saitama Medical University International Medical Center, Saitama, Japan. FAU - Narita, Masataka AU - Narita M AD - Department of Cardiology, Saitama Medical University International Medical Center, Saitama, Japan. FAU - Matsumoto, Kazuhisa AU - Matsumoto K AUID- ORCID: 0000-0002-5648-8135 AD - Department of Cardiology, Saitama Medical University International Medical Center, Saitama, Japan. FAU - Ikeda, Yoshifumi AU - Ikeda Y AD - Department of Cardiology, Saitama Medical University International Medical Center, Saitama, Japan. FAU - Sumitomo, Naokata AU - Sumitomo N AD - Department of Pediatric Cardiology, Saitama Medical University International Medical Center, Saitama, Japan. FAU - Matsumoto, Kazuo AU - Matsumoto K AD - Department of Cardiology, Higashimatsuyama Medical Association Hospital, Higashimatsuyama, Saitama, Japan. FAU - Kato, Ritsushi AU - Kato R AUID- ORCID: 0000-0002-9989-8708 AD - Department of Cardiology, Saitama Medical University International Medical Center, Saitama, Japan. LA - eng PT - Journal Article PT - Review DEP - 20260204 PL - United States TA - Pacing Clin Electrophysiol JT - Pacing and clinical electrophysiology : PACE JID - 7803944 SB - IM MH - Humans MH - Female MH - Child MH - Male MH - Feasibility Studies MH - *Catheter Ablation MH - Retrospective Studies MH - *Body Weight MH - *Tachycardia, Supraventricular/surgery/diagnosis MH - *Body Surface Potential Mapping/methods/instrumentation MH - Child, Preschool MH - Treatment Outcome MH - Adolescent MH - Reproducibility of Results PMC - PMC13124452 OTO - NOTNLM OT - Rhythmia mapping system OT - WPW syndrome OT - catheter ablation OT - dual-chamber map OT - pediatric patients OT - supraventricular arrhythmia OT - weighing less than 20 kg EDAT- 2026/02/05 06:31 MHDA- 2026/04/29 00:34 PMCR- 2026/04/29 CRDT- 2026/02/05 01:45 PHST- 2026/01/20 00:00 [revised] PHST- 2025/02/04 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/04/29 00:34 [medline] PHST- 2026/02/05 06:31 [pubmed] PHST- 2026/02/05 01:45 [entrez] PHST- 2026/04/29 00:00 [pmc-release] AID - PACE70151 [pii] AID - 10.1111/pace.70151 [doi] PST - ppublish SO - Pacing Clin Electrophysiol. 2026 May;49(5):523-530. doi: 10.1111/pace.70151. Epub 2026 Feb 4. PMID- 41639908 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 1479-5868 (Electronic) IS - 1479-5868 (Linking) VI - 23 IP - 1 DP - 2026 Feb 4 TI - Bidirectional associations between smart device use and body mass index among children aged 3 to 5 years: a longitudinal study. LID - 10.1186/s12966-026-01883-3 [doi] LID - 18 AB - BACKGROUND: The increase in smart device use, including smartphones and tablets, among young children has raised concerns about its impact on health, particularly on body mass index (BMI). However, the bidirectional associations between smart device use and BMI in preschoolers remain unclear. This study examined the longitudinal associations, considering the moderating effects of mother-child interactions and child sex. METHODS: Data were obtained from the Longitudinal Examination Across Prenatal and Postpartum Health in Taiwan, a cohort study conducted in Taipei, Taiwan. In total, 590 preschoolers were assessed at ages 3, 4, and 5 years. Smart device use, BMI z-scores, and mother-child interaction quality were evaluated using validated parent-reported questionnaires. The random-intercept cross-lagged panel model was used to investigate bidirectional associations, adjusting for stable confounders. Multiple-group models examined the moderating effects of mother-child interactions and child sex. Model estimates were reported as standardized coefficients. RESULTS: Higher BMI z-scores at age 4 years were linked to increased device use at age 5 years (beta = 0.36; 95% CI, 0.05-0.67). Multiple-group models revealed that among dyads with lower mother-child interactions, higher device use at age 3 years was associated with higher BMI at age 4 years (beta = 0.40; 95% CI, 0.07 to 0.72), which was subsequently linked to greater device use at age 5 years (beta = 0.50; 95% CI, 0.10 to 0.90). Additionally, higher device use at age 4 years was associated with higher BMI at age 5 years (beta = 0.65; 95% CI, 0.31 to 1.00). A similar bidirectional pattern was observed among boys, while no significant cross-lagged associations were found among girls. In contrast, high-quality mother-child interactions revealed higher device use at age 4 years was associated with lower BMI at age 5 years, suggesting a protective role against prolonged device use and subsequent BMI increases. CONCLUSIONS: Our study indicates bidirectional associations between smart device use and BMI among preschoolers, emphasizing the protective role of high-quality mother-child interactions. Interventions should focus on enhancing parent-child relationships, limiting device use, and promoting active engagement. Future studies should investigate the effect of media content and children's self-regulation on these associations. CI - (c) 2026. The Author(s). FAU - Chakranon, Pairote AU - Chakranon P AD - School of Public Health, College of Public Health, Taipei Medical University, New Taipei, Taiwan. FAU - Huang, Jian-Pei AU - Huang JP AD - Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan. FAU - Au, Heng-Kien AU - Au HK AD - Department of Obstetrics and Gynecology, Taipei Medical University Hospital, Taipei, Taiwan. AD - Department of Obstetrics and Gynecology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. FAU - Chiou, Hawjeng AU - Chiou H AD - Department of Business Administration, College of Management, National Taiwan Normal University, Taipei, Taiwan. FAU - Lin, Chen-Li AU - Lin CL AD - Department of Obstetrics & Gynecology, Taipei City Hospital, Heping Fuyou Branch, Taipei, Taiwan. FAU - Chen, Yi-Yung AU - Chen YY AD - Department of Obstetrics and Gynecology, Mackay Memorial Hospital, Taipei, Taiwan. FAU - Mao, Shih-Peng AU - Mao SP AD - Department of Obstetrics and Gynecology, Taipei Medical University-Shuang Ho Hospital, Ministry of Health and Welfare, New Taipei, Taiwan. FAU - Kim, Pilyoung AU - Kim P AD - Department of Psychology, College of Arts, Humanities and Social Sciences, University of Denver, Denver, CO, USA. AD - Department of Psychology, Ewha Womans University, Seoul, South Korea. FAU - Hsu, Hsueh-Wen AU - Hsu HW AD - Master Program in Applied Epidemiology, College of Public Health, Taipei Medical University, Taipei, Taiwan. FAU - Chen, Yi-Hua AU - Chen YH AD - School of Public Health, College of Public Health, Taipei Medical University, New Taipei, Taiwan. yichen.tmu@gmail.com. AD - Neuroscience Research Center, Taipei Medical University, Taipei, Taiwan. yichen.tmu@gmail.com. AD - Research Center of Health Equity, College of Public Health, Taipei Medical University, New Taipei, Taiwan. yichen.tmu@gmail.com. LA - eng GR - NSTC 114-2314-B-038 -039 -MY3, NSTC 114-2621-M-038-001, NSTC 113-2621-M-038-003, NSTC 112-2621-M-038-003, MOST 111-2314-B-038-043-MY3, MOST 108-2314-B-038-083-MY3, MOST 105-2314-B-038-031-MY3, NSC 102-2314-B-038-038-MY3, and NSC 99-2628-B-038-015-MY3/National Science and Technology Council/ GR - the Higher Education Sprout Project; DP2-TMU-112-O-10, DP2-TMU-113-O-04, DP2-TMU-114-O-03/Ministry of Education/ PT - Journal Article DEP - 20260204 PL - England TA - Int J Behav Nutr Phys Act JT - The international journal of behavioral nutrition and physical activity JID - 101217089 SB - IM MH - Humans MH - *Body Mass Index MH - Child, Preschool MH - Female MH - Longitudinal Studies MH - Male MH - Taiwan MH - *Mother-Child Relations MH - *Smartphone/statistics & numerical data MH - Surveys and Questionnaires MH - *Computers, Handheld/statistics & numerical data PMC - PMC12958733 OTO - NOTNLM OT - Body mass index OT - Mother-child interactions OT - Preschooler OT - Smart device use COIS- Declarations. Ethical approval and consent to participate: This study was approved by the Institutional Review Board of MacKay Memorial Hospital (16MMHIS130). Written informed consent was obtained from each participant in this study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/05 06:32 MHDA- 2026/03/07 01:38 PMCR- 2026/02/04 CRDT- 2026/02/05 00:02 PHST- 2025/05/07 00:00 [received] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/03/07 01:38 [medline] PHST- 2026/02/05 06:32 [pubmed] PHST- 2026/02/05 00:02 [entrez] PHST- 2026/02/04 00:00 [pmc-release] AID - 10.1186/s12966-026-01883-3 [pii] AID - 1883 [pii] AID - 10.1186/s12966-026-01883-3 [doi] PST - epublish SO - Int J Behav Nutr Phys Act. 2026 Feb 4;23(1):18. doi: 10.1186/s12966-026-01883-3. PMID- 41639635 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Feb 4 TI - Support and concerns: Dutch health care professionals' views on the use of a childhood obesity prediction toolbox. LID - 10.1186/s12887-026-06572-5 [doi] LID - 184 AB - BACKGROUND: Childhood obesity is a major and increasing public health concern. Early prediction of the risk of childhood obesity may lead to targeted preventative interventions. To develop a prediction-toolbox that is suitable for clinical implementation, it is imperative to align it with the perceptions of health care professionals (HCPs), but this aspect remains relatively underexplored. This study aimed to explore the perceptions of Dutch HCPs regarding the concept of a childhood obesity prediction toolbox. METHODS: A qualitative study design comprising semi-structured interviews (n=15) with Dutch HCPs was used. HCPs included youth health care practitioners, youth health care nurses and policy advisors employed at the municipal health service of Amsterdam. Perceptions were explored regarding the concept of a three-element childhood obesity prediction toolbox of the EndObesity project, which consists of a prediction tool, prevention strategies to support families of high-risk infants, and communication tips for HCPs. The data were analysed through reflexive thematic analysis. RESULTS: HCPs were positive about early identification of the risk of future childhood obesity and the support of high-risk infants. They acknowledged the potential benefits of personalized care facilitated by such risk prediction, but concerns were raised regarding its validity and its added value compared with the clinical judgement of HCPs. HCPs also expressed some negative connotations regarding risk communication e.g. making parents feel insecure or judged, especially in vulnerable situations. Finally, HCPs acknowledged the complexity of childhood obesity prevention and emphasized the need for a complementary broader approach at both the municipal and national policy levels. CONCLUSIONS: Dutch HCPs generally supported the potential use of a childhood obesity prediction toolbox, but they also expressed concerns regarding the validity, the added value of the toolbox and about risk communication. These concerns must be addressed in further development of the toolbox. CI - (c) 2026. The Author(s). FAU - Manshanden, Anna AU - Manshanden A AD - Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. a.manshanden@vu.nl. AD - Amsterdam Public Health, Amsterdam, The Netherlands. a.manshanden@vu.nl. FAU - Groot-Sluijsmans, Barbara AU - Groot-Sluijsmans B AD - Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. AD - Amsterdam Public Health, Amsterdam, The Netherlands. FAU - M'Rani Alaoui, Nohaila AU - M'Rani Alaoui N AD - Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. FAU - Seidell, Jacob C AU - Seidell JC AD - Department of Health Sciences, Faculty of Science, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands. AD - Amsterdam Public Health, Amsterdam, The Netherlands. FAU - Dijkstra, S Coosje AU - Dijkstra SC AD - Amsterdam Public Health, Amsterdam, The Netherlands. AD - Amsterdam UMC, Location Vrije Universiteit Amsterdam, Public and Occupational Health, De Boelelaan 1117, Amsterdam, Netherlands. LA - eng GR - 727565/Horizon 2020 research and innovation program, European Union/ GR - 529051026/ZONMW_/ZonMw/Netherlands PT - Journal Article DEP - 20260204 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Netherlands MH - *Pediatric Obesity/diagnosis/prevention & control MH - *Attitude of Health Personnel MH - Risk Assessment/methods MH - Child MH - Female MH - Male MH - Qualitative Research MH - Interviews as Topic PMC - PMC12958768 OTO - NOTNLM OT - Child OT - Communication OT - Infant OT - Obesity OT - Parents OT - Prevention OT - Qualitative OT - Risk COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the Declaration of Helsinki and was approved by the Research Ethics Review Committee of the Faculty of Science of the Vrije Universiteit Amsterdam (BETHCIE). Review number of approval letter: 22-49. Informed consent was obtained from all participants, who were all over 18 years of age. Clinical trial number: not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/05 00:31 MHDA- 2026/03/06 19:44 PMCR- 2026/02/04 CRDT- 2026/02/04 23:44 PHST- 2024/11/18 00:00 [received] PHST- 2026/01/22 00:00 [accepted] PHST- 2026/03/06 19:44 [medline] PHST- 2026/02/05 00:31 [pubmed] PHST- 2026/02/04 23:44 [entrez] PHST- 2026/02/04 00:00 [pmc-release] AID - 10.1186/s12887-026-06572-5 [pii] AID - 6572 [pii] AID - 10.1186/s12887-026-06572-5 [doi] PST - epublish SO - BMC Pediatr. 2026 Feb 4;26(1):184. doi: 10.1186/s12887-026-06572-5. PMID- 41638751 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260920 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 2 DP - 2026 Feb 4 TI - Recombinant human growth hormone (rHGH) for muscle enhancement in knee osteoarthritis: protocol for a pilot, randomised placebo-controlled trial. PG - e106999 LID - 10.1136/bmjopen-2025-106999 [doi] LID - e106999 AB - INTRODUCTION: The management of active patients with symptomatic knee osteoarthritis (KnOA) who are too young for total knee arthroplasty poses a specific challenge to clinicians. Research studies show that improving quadriceps muscle strength improves pain and function; however, aspects of the disease render it difficult for patients to achieve and maintain improvements. Recombinant human growth hormone (rHGH) is shown to increase the magnitude and duration of muscle growth when combined with exercise treatment in adult populations. Hence, rHGH combined with physical therapy may provide meaningful benefits in the treatment of KnOA. METHODS AND ANALYSIS: This is a single-centre, double-blind, randomised trial to pilot a future Phase III trial from 2025 to 2028. Participants are aged 18-60 with clinical and radiographic evidence of isolated degenerative arthritis of the knee (patellofemoral or tibiofemoral). The investigational product is rHGH (Saizen (somatropin of rDNA origin, EMD Serono)) and a saline placebo. Participants will deliver the solution via subcutaneous injection area once per day at a dose of 0.5 mg HGH per body surface area (0.5 mg/m(2)) for 6 weeks, alongside participation in a lower limb strengthening programme developed by rehabilitation specialists. 17 participants will be recruited into each study arm.The primary outcomes are feasibility (compliance with the study drug regimen for the 6-week administration period and enrolment rate) and safety (the proportion of minor and major adverse events between groups). The primary endpoint for these outcomes will be at 6 weeks. The secondary outcomes are knee extension strength, knee flexion strength, radiographic arthritis progression, thigh muscle circumference, MRI-measured quadriceps muscle volume and patient-reported outcome measures (Knee Osteoarthritis Outcome Score (KOOS), SF-20 and Tegner). The primary endpoint for these outcomes will be at 12 weeks, and the final endpoint will be 24 months, where final radiographic (X-ray) assessment will take place.The primary outcome of compliance will be a calculation of mean compliance between groups, which can be analysed as a t-test after the treatment period. A two-sample, two-sided t-test will compare the clinical (secondary) outcome of greatest interest: knee extension strength at baseline versus week 6 compared between treatment groups. Other secondary outcomes will be compared using a simple linear mixed-effects model. The chi(2) test will be used to determine whether the number of participants who made meaningful changes was different between groups. The null hypotheses are that the rHGH and placebo groups will have no difference in compliance rates, safety events, knee extension strength at 12 weeks and arthritis grade progression at 24 months. ETHICS AND DISSEMINATION: This study has been approved by the Sunnybrook Research Institute Research and Ethics Board (#6427) and received a no-objection letter from Health Canada Clinical Trials. The primary sponsor is the Sunnybrook Centre for Clinical Trial Studies (CCTS). The findings of this study will be published in a peer-reviewed journal and presented at orthopaedic conferences. TRIAL REGISTRATION NUMBER: NCT07036003. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Shah, Ajay AU - Shah A AUID- ORCID: 0000-0003-3211-7185 AD - Division of Orthopaedics, Department of Surgery, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada ajay.shah@medportal.ca. AD - Tanenbaum Institute for Sport Science, University of Toronto, Toronto, Ontario, Canada. FAU - Ravi, Bheeshma AU - Ravi B AUID- ORCID: 0000-0003-1829-6885 AD - Division of Orthopaedics, Department of Surgery, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada. AD - Tanenbaum Institute for Sport Science, University of Toronto, Toronto, Ontario, Canada. AD - Division of Orthopaedics, Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. FAU - Tomescu, Sebastian AU - Tomescu S AD - Division of Orthopaedics, Department of Surgery, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada. AD - Tanenbaum Institute for Sport Science, University of Toronto, Toronto, Ontario, Canada. AD - Division of Orthopaedics, Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. FAU - Catapano, Michael AU - Catapano M AUID- ORCID: 0000-0003-3051-227X AD - Tanenbaum Institute for Sport Science, University of Toronto, Toronto, Ontario, Canada. AD - Division of Physical Medicine and Rehabilitation, Sunnybrook Health Sciences Centre Department of Medicine, Toronto, Ontario, Canada. FAU - Burkhart, Timothy A AU - Burkhart TA AD - Tanenbaum Institute for Sport Science, University of Toronto, Toronto, Ontario, Canada. AD - Kinesiology and Physical Education, University of Toronto, Toronto, Ontario, Canada. FAU - Whyne, Cari AU - Whyne C AD - Tanenbaum Institute for Sport Science, University of Toronto, Toronto, Ontario, Canada. AD - Holland Bone and Joint Program, Sunnybrook Research Institute, Toronto, Ontario, Canada. FAU - Kiss, Alexander AU - Kiss A AD - Holland Bone and Joint Program, Sunnybrook Research Institute, Toronto, Ontario, Canada. FAU - Marks, Paul AU - Marks P AD - Division of Orthopaedics, Department of Surgery, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada. AD - Tanenbaum Institute for Sport Science, University of Toronto, Toronto, Ontario, Canada. AD - Division of Orthopaedics, Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. FAU - Wasserstein, David N AU - Wasserstein DN AD - Division of Orthopaedics, Department of Surgery, University of Toronto Temerty Faculty of Medicine, Toronto, Ontario, Canada. AD - Tanenbaum Institute for Sport Science, University of Toronto, Toronto, Ontario, Canada. AD - Division of Orthopaedics, Department of Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. LA - eng SI - ClinicalTrials.gov/NCT07036003 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260204 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - 12629-01-5 (Human Growth Hormone) RN - 0 (Recombinant Proteins) SB - IM MH - Humans MH - *Osteoarthritis, Knee/drug therapy/therapy/physiopathology MH - *Human Growth Hormone/therapeutic use/administration & dosage MH - Double-Blind Method MH - *Muscle Strength/drug effects MH - Middle Aged MH - Adult MH - Recombinant Proteins/therapeutic use MH - Pilot Projects MH - Male MH - *Quadriceps Muscle/drug effects MH - Female MH - Young Adult MH - Adolescent MH - Treatment Outcome MH - Exercise Therapy PMC - PMC12878478 OTO - NOTNLM OT - Adult orthopaedics OT - Clinical Trial OT - Knee OT - Musculoskeletal disorders OT - SPORTS MEDICINE COIS- Competing interests: None declared. EDAT- 2026/02/05 00:30 MHDA- 2026/02/05 00:31 PMCR- 2026/02/04 CRDT- 2026/02/04 20:43 PHST- 2026/02/05 00:31 [medline] PHST- 2026/02/05 00:30 [pubmed] PHST- 2026/02/04 20:43 [entrez] PHST- 2026/02/04 00:00 [pmc-release] AID - bmjopen-2025-106999 [pii] AID - 10.1136/bmjopen-2025-106999 [doi] PST - epublish SO - BMJ Open. 2026 Feb 4;16(2):e106999. doi: 10.1136/bmjopen-2025-106999. PMID- 41638646 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1873-474X (Electronic) IS - 0736-5748 (Linking) VI - 86 IP - 1 DP - 2026 Feb TI - Serum Cingulin and Interleukin-6 Levels in Children With Specific Learning Disorder. PG - e70104 LID - 10.1002/jdn.70104 [doi] AB - BACKGROUND: This study examined cingulin and interleukin-6 (IL-6) levels in children with specific learning disorder (SLD) to explore their association with inflammation and tight junction-related barrier biological processes in the context of the disorder. METHODS: The research compared 40 children with SLD and 41 healthy peers using a cross-sectional, case-controlled design. Serum cingulin and IL-6 levels were measured using the ELISA method. The Mathematics, Reading and Writing Assessment Scale (MOYA) teacher and parent forms were applied to evaluate disease severity in the SLD group. RESULTS: Both cingulin and IL-6 levels were significantly higher in the SLD group than in the controls (p = 0.005 and p = 0.009, respectively). These differences maintained their significance during covariance analysis. These findings indicate a significant group-related difference in cingulin and IL-6 levels, and that this was independent of age, gender and body mass index. A positive correlation was determined between cingulin and IL-6 in the SLD group (r = 0.472, p = 0.020). In the context of logistic regression analysis, cingulin demonstrated an independent association with the presence of SLD (OR = 1.006, p = 0.041), while IL-6 did not. An AUC value of 0.679 was calculated for cingulin at receiver operating characteristic analysis (p = 0.003). CONCLUSION: Elevated serum cingulin and IL-6 levels in children with SLD may reflect inflammatory activity and barrier-related biological processes associated with the disorder. These findings should be interpreted as preliminary and require confirmation in larger, longitudinal studies incorporating direct assessments of barrier function. CI - (c) 2026 International Society for Developmental Neuroscience. FAU - Kocaman, Orhan AU - Kocaman O AUID- ORCID: 0000-0002-7504-5604 AD - Department of Child and Adolescent Psychiatry, Faculty of Medicine, Alanya Alaaddin Keykubat University, Antalya, Turkey. FAU - Maytalman, Erkan AU - Maytalman E AUID- ORCID: 0000-0001-5284-7439 AD - Department of Medical Pharmacology, Faculty of Medicine, Alanya Alaaddin Keykubat University, Antalya, Turkey. LA - eng PT - Journal Article PL - United States TA - Int J Dev Neurosci JT - International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience JID - 8401784 RN - 0 (Interleukin-6) RN - 0 (Membrane Proteins) SB - IM MH - Humans MH - Female MH - Male MH - *Interleukin-6/blood MH - Child MH - Case-Control Studies MH - Cross-Sectional Studies MH - *Learning Disabilities/blood MH - *Membrane Proteins/blood MH - Enzyme-Linked Immunosorbent Assay OTO - NOTNLM OT - blood-brain barrier OT - cingulin OT - inflammation OT - interleukin-6 OT - specific learning disorder EDAT- 2026/02/05 00:30 MHDA- 2026/02/05 00:31 CRDT- 2026/02/04 20:03 PHST- 2026/01/17 00:00 [revised] PHST- 2025/12/15 00:00 [received] PHST- 2026/01/26 00:00 [accepted] PHST- 2026/02/05 00:31 [medline] PHST- 2026/02/05 00:30 [pubmed] PHST- 2026/02/04 20:03 [entrez] AID - 10.1002/jdn.70104 [doi] PST - ppublish SO - Int J Dev Neurosci. 2026 Feb;86(1):e70104. doi: 10.1002/jdn.70104. PMID- 41638532 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 2212-2672 (Print) IS - 2212-2672 (Linking) VI - 126 IP - 6 DP - 2026 Jun TI - Household Water Insecurity Is Associated With Greater Likelihood of Early Exclusive Breastfeeding Cessation and Diarrhea Among Children Aged 6 to 59 Months in Ethiopia: Data From Haramaya University Health and Demographic Surveillance System. PG - 156303 LID - S2212-2672(26)00018-3 [pii] LID - 10.1016/j.jand.2026.156303 [doi] AB - INTRODUCTION: In low-resource settings, exclusive breastfeeding (EBF) and household water security are recognized contributors to child health. Yet few studies have examined how they are related. OBJECTIVES: This study aims to (1) test the relationship between domains of household water insecurity and EBF cessation before 6 months, and (2) examine the association between water insecurity and recent child diarrheal disease and stunting. DESIGN: The Haramaya University Health and Demographic Surveillance System is a cross-sectional survey. PARTICIPANTS/SETTING: Mother-child (aged 6-59 months) dyads (n = 1019) were recruited from smallholder agricultural households in rural Eastern Ethiopia in 2019. MAIN OUTCOME MEASURES: The primary outcome was EBF cessation before 6 months. Secondary outcomes were children's diarrhea (last 2 weeks) and stunting. Exposure variables assessing water insecurity included time spent fetching water, objective water quality (Escherichia coli presence), water source reliability, and overall household water insecurity status (classified using the Household Water InSecurity Experiences Scale). STATISTICAL ANALYSES: Survey logistic regression models were used to assess associations of water insecurity domains with early EBF cessation, diarrhea, and stunting. RESULTS: Poor water quality (adjusted odds ratio [AOR], 1.42; 95% confidence interval [CI], 1.06-1.98), unreliable water (AOR, 1.44; 95% CI, 1.04-1.98), and water fetching time >30 minutes (AOR, 1.54; 95% CI, 1.15-2.05) were associated with early EBF cessation risk. Children in households classified as moderate (AOR, 1.54; 95% CI, 1.03-2.30) or high water insecurity (AOR, 2.07; 95% CI, 1.33-3.24) had a greater risk of diarrhea. No association was observed between domains of water insecurity and stunting. CONCLUSION: Multiple domains of water insecurity were associated with early EBF cessation, and overall water insecurity was associated with children's diarrheal risk. Water insecurity has been identified as a key programmatic and policy consideration for early childhood nutrition. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Roba, Kedir Teji AU - Roba KT AD - Department of Biobehavioral Health, Pennsylvania State University, University Park, PA, United States; College of Health and Medical Sciences, Haramaya University, Ethiopia. Electronic address: kedir.t.roba@gmail.com. FAU - Roba, Akililu Abrham AU - Roba AA AD - College of Health and Medical Sciences, Haramaya University, Ethiopia. FAU - Hassen, Jemal Yousuf AU - Hassen JY AD - Department of Rural Development and Agricultural Innovation, Haramaya University, Haramaya, Diredawa, Ethiopia. FAU - Thompson, Gretchen AU - Thompson G AD - Department of Behavioral, Epidemiological and Clinical Sciences, FHI 360, Durham, NC 27701, USA. FAU - Brewis, Alexandra AU - Brewis A AD - School of Human Evolution and Social Change, Arizona State University, Tempe, AZ 85284, USA. FAU - Rosinger, Asher Y AU - Rosinger AY AD - Department of Biobehavioral Health, Pennsylvania State University, University Park, PA, United States; Department of Anthropology, Pennsylvania State University, University Park, PA, United States. LA - eng PT - Journal Article DEP - 20260203 PL - United States TA - J Acad Nutr Diet JT - Journal of the Academy of Nutrition and Dietetics JID - 101573920 SB - IM MH - Humans MH - Ethiopia/epidemiology MH - *Breast Feeding/statistics & numerical data MH - Female MH - Cross-Sectional Studies MH - Infant MH - Child, Preschool MH - *Diarrhea/epidemiology/etiology MH - Male MH - Growth Disorders/epidemiology/etiology MH - Family Characteristics MH - *Water Insecurity MH - Rural Population/statistics & numerical data MH - *Water Supply/statistics & numerical data MH - Water Quality OTO - NOTNLM OT - Breastfeeding OT - Ethiopia OT - Stunting OT - Water insecurity OT - Water quality EDAT- 2026/02/05 00:30 MHDA- 2026/05/22 00:33 CRDT- 2026/02/04 19:14 PHST- 2024/07/16 00:00 [received] PHST- 2025/12/22 00:00 [revised] PHST- 2026/01/26 00:00 [accepted] PHST- 2026/05/22 00:33 [medline] PHST- 2026/02/05 00:30 [pubmed] PHST- 2026/02/04 19:14 [entrez] AID - S2212-2672(26)00018-3 [pii] AID - 10.1016/j.jand.2026.156303 [doi] PST - ppublish SO - J Acad Nutr Diet. 2026 Jun;126(6):156303. doi: 10.1016/j.jand.2026.156303. Epub 2026 Feb 3. PMID- 41638041 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260730 IS - 1525-5069 (Electronic) IS - 1525-5050 (Linking) VI - 177 DP - 2026 Apr TI - Telecoaching Interventions for People with Epilepsy: Enhancing Physical Activity and Quality of Life through Digital Health. A Systematic Review. PG - 110929 LID - S1525-5050(26)00050-8 [pii] LID - 10.1016/j.yebeh.2026.110929 [doi] AB - People with Epilepsy exhibit low levels of physical activity compared with the general population, despite evidence suggesting potential benefits for seizure control, physical fitness and psychosocial well-being. Persistent barriers such as fear of seizures, limited access to supervised programs, transportation difficulties, and time constraints contribute to sedentary behaviour. Telecoaching (TC), which delivers structured exercise programs through digital technologies, may help overcome these barriers. This systematic review aimed to evaluate the feasibility and potential effects of TC-based training physical activity interventions in individuals with epilepsy, focusing on adherence, QoL, physical fitness and psychological outcomes. A systematic search of PubMed, Web of Science, and Scopus identified 1086 records, of which 7 studies involving 342 participants met the inclusion criteria. Interventions included remotely delivered aerobic, resistance, flexibility, and combined exercise programs. Study quality ranged from "fair" to "good". TC-based interventions were generally safe and feasible, with no major adverse events reported. Evidence suggest potential benefits for physical fitness and psychosocial outcomes, particularly in paediatric populations, although the limited number and heterogeneity of studies preclude definitive conclusions, especially regarding seizure-related outcomes. Future research should focus on standardized TC programs, long-term follow-up, and adequately powered randomized trials to confirm effectiveness and sustainability. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Leale, Ignazio AU - Leale I AD - Sport and Exercise Research Unit, Department of Psychology, Educational Sciences and Human Movement, University of Palermo 90144 Palermo, Italy. Electronic address: ignazio.leale@unipa.it. FAU - Orlando, Fabio Tiziano AU - Orlando FT AD - Sport and Exercise Research Unit, Department of Psychology, Educational Sciences and Human Movement, University of Palermo 90144 Palermo, Italy. FAU - Di Stefano, Vincenzo AU - Di Stefano V AD - Department of Biomedicine, Neuroscience, and Advanced Diagnostics (BiND), University of Palermo 90129 Palermo, Italy. FAU - Lima, Salvatore Maria AU - Lima SM AD - Department of Biomedicine, Neuroscience, and Advanced Diagnostics (BiND), University of Palermo 90129 Palermo, Italy. FAU - Gomez-Lopez, Manuel AU - Gomez-Lopez M AD - Department of Physical Activity and Sport, Faculty of Sports Sciences, University of Murcia, Santiago de la Ribera, 30720 Murcia, Spain. FAU - Brighina, Filippo AU - Brighina F AD - Department of Biomedicine, Neuroscience, and Advanced Diagnostics (BiND), University of Palermo 90129 Palermo, Italy. FAU - Battaglia, Giuseppe AU - Battaglia G AD - Sport and Exercise Research Unit, Department of Psychology, Educational Sciences and Human Movement, University of Palermo 90144 Palermo, Italy; Disability and Neurodiversity Center, University of Palermo (Ce.N.Dis.), Palermo, Italy. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260203 PL - United States TA - Epilepsy Behav JT - Epilepsy & behavior : E&B JID - 100892858 SB - IM MH - Humans MH - *Epilepsy/psychology/rehabilitation MH - Digital Health MH - *Quality of Life/psychology MH - *Exercise/psychology MH - *Exercise Therapy/methods OTO - NOTNLM OT - Epilepsy OT - Exercise therapy OT - Physical activity OT - Telecoaching OT - Telehealth COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/02/05 00:30 MHDA- 2026/03/06 08:59 CRDT- 2026/02/04 18:09 PHST- 2025/11/22 00:00 [received] PHST- 2026/01/29 00:00 [revised] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/03/06 08:59 [medline] PHST- 2026/02/05 00:30 [pubmed] PHST- 2026/02/04 18:09 [entrez] AID - S1525-5050(26)00050-8 [pii] AID - 10.1016/j.yebeh.2026.110929 [doi] PST - ppublish SO - Epilepsy Behav. 2026 Apr;177:110929. doi: 10.1016/j.yebeh.2026.110929. Epub 2026 Feb 3. PMID- 41637567 OWN - NLM STAT- MEDLINE DCOM- 20260710 LR - 20260710 IS - 1479-683X (Electronic) IS - 0804-4643 (Linking) VI - 194 IP - 2 DP - 2026 Feb 4 TI - Adrenal androgens as predictors of growth characteristics in premature pubarche. PG - 225-232 LID - 10.1093/ejendo/lvag024 [doi] AB - BACKGROUND: Premature pubarche (PP) is characterized by the early onset of pubic or axillary hair, body odor, or mild acne, most commonly reflected by elevated plasma dehydroepiandrosterone-sulfate (DHEA-S) concentrations. However, recent evidence suggests that 11-oxygenated adrenal androgens [11beta-hydroxyandrostenedione (11OHA4), 11beta-hydroxytestosterone (11OHT)] may better represent true androgenic activity. AIM: This study aims to evaluate the predictive value of adrenal androgens in determining growth characteristics among girls with PP. SUBJECTS AND METHODS: A prospective study was conducted to evaluate anthropometric and clinical features and to quantify plasma adrenal androgens-including DHEA, DHEA-S, androstenedione (A4), androsterone, 11OHA4, and 11OHT-using liquid chromatography-mass spectrometry in 53 girls with isolated PP at presentation and during follow-up. Thirty-six age-matched girls without PP served as the control group. RESULTS: The height, body mass index-standard deviation score (SDS), DHEA, DHEA-S, A4, androsterone, and 17OH-pregnenolone concentrations were higher (P < .0001), whereas no difference in 11OHA4 and 11OHT concentrations was observed in the PP group compared with controls. There was no correlation of adrenal androgen concentrations with height, corrected height, and growth velocity at baseline or during follow-up of 2.7 years. Corrected height SDS was positively correlated with baseline corrected height SDS (r = .63, P < .0001), baseline bone age (BA)/chronological age ratio (r = .31, P = .02), and baseline BA SDS (r = .32, P = .01) but not with hormone concentrations. CONCLUSION: Isolated idiopathic PP appears to be a benign variant of normal development. In this setting, adrenal androgen concentrations are not associated with adverse linear growth outcomes and are unlikely to influence clinical management, supporting a conservative approach after exclusion of pathological causes. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of European Society of Endocrinology. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Eltan, Mehmet AU - Eltan M AUID- ORCID: 0000-0001-6977-9620 AD - Department of Pediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul 34854, Turkey. FAU - Yavas Abali, Zehra AU - Yavas Abali Z AD - Department of Pediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul 34854, Turkey. FAU - Canbaz, Aylin Tugba AU - Canbaz AT AD - Department of Pediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul 34854, Turkey. FAU - Kirkgoz, Tarik AU - Kirkgoz T AD - Department of Pediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul 34854, Turkey. FAU - Kaygusuz, Sare Betul AU - Kaygusuz SB AD - Department of Pediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul 34854, Turkey. FAU - Gurpinar Tosun, Busra AU - Gurpinar Tosun B AUID- ORCID: 0000-0002-7588-9807 AD - Department of Pediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul 34854, Turkey. FAU - Seven Menevse, Tuba AU - Seven Menevse T AUID- ORCID: 0000-0002-1902-7057 AD - Department of Pediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul 34854, Turkey. FAU - Helvacioglu, Didem AU - Helvacioglu D AUID- ORCID: 0000-0001-8687-6326 AD - Department of Pediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul 34854, Turkey. FAU - Yaman, Ali AU - Yaman A AD - Department of Biochemistry, Marmara University, School of Medicine, Istanbul 34854, Turkey. FAU - Haklar, Goncagul AU - Haklar G AD - Department of Biochemistry, Marmara University, School of Medicine, Istanbul 34854, Turkey. FAU - Turan, Serap AU - Turan S AD - Department of Pediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul 34854, Turkey. FAU - Bereket, Abdullah AU - Bereket A AUID- ORCID: 0000-0002-6584-9043 AD - Department of Pediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul 34854, Turkey. FAU - Guran, Tulay AU - Guran T AUID- ORCID: 0000-0003-2658-6866 AD - Department of Pediatric Endocrinology and Diabetes, Marmara University, School of Medicine, Istanbul 34854, Turkey. LA - eng PT - Journal Article PL - England TA - Eur J Endocrinol JT - European journal of endocrinology JID - 9423848 RN - 0 (Androgens) RN - 564-32-9 (11-hydroxyandrostenedione) RN - 1816-85-9 (11-hydroxytestosterone) RN - 57B09Q7FJR (Dehydroepiandrosterone Sulfate) RN - 0 (Hydroxytestosterones) RN - 409J2J96VR (Androstenedione) SB - IM MH - Predictive Value of Tests MH - Humans MH - Female MH - Child MH - Prospective Studies MH - Case-Control Studies MH - Follow-Up Studies MH - Anthropometry MH - *Puberty, Precocious/blood/physiopathology MH - *Androgens/blood MH - Liquid Chromatography-Mass Spectrometry MH - Body Mass Index MH - Body Height MH - *Dehydroepiandrosterone Sulfate/blood MH - *Hydroxytestosterones/blood MH - *Androstenedione/analogs & derivatives/blood/analogs & derivatives OTO - NOTNLM OT - 11-oxyandrogens OT - 11beta-hydroxyandrostenedione OT - 11beta-hydroxytestosterone OT - DHEA-S OT - growth OT - premature pubarche COIS- Conflict of interest: The authors have nothing to declare. EDAT- 2026/02/04 19:37 MHDA- 2026/02/23 13:06 CRDT- 2026/02/04 14:52 PHST- 2025/12/09 00:00 [received] PHST- 2026/01/22 00:00 [revised] PHST- 2026/01/30 00:00 [accepted] PHST- 2026/02/23 13:06 [medline] PHST- 2026/02/04 19:37 [pubmed] PHST- 2026/02/04 14:52 [entrez] AID - 8460662 [pii] AID - 10.1093/ejendo/lvag024 [doi] PST - ppublish SO - Eur J Endocrinol. 2026 Feb 4;194(2):225-232. doi: 10.1093/ejendo/lvag024. PMID- 41637479 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 2 DP - 2026 TI - Exploring the utility of dynamic motor control to assess recovery following pediatric traumatic brain injury: A pilot study. PG - e0322674 LID - 10.1371/journal.pone.0322674 [doi] LID - e0322674 AB - Pediatric traumatic brain injury often leads to long-term disability. Unfortunately, while currently used standard clinical measures can effectively capture secondary functional impairments, they do not measure neurologic impairment directly. Therefore, the objective of this study was to evaluate the feasibility of walking dynamic motor control (walk-DMC) assessments to more directly measure neurological impairment and recovery for individuals post-traumatic brain injury. To accomplish this, we assessed the trajectory of walk-DMC (a single summary measure that reflects the overall complexity of muscle activation patterns during walking) and standard clinical measures of balance, mobility, and function in a small cohort of individuals post-traumatic brain injury at different time points post-injury (during acute rehabilitation, short- and long-term follow-up). At enrollment all participants demonstrated substantial neurological impairment. All clinical measures showed an initial deficit followed by recovery, with most returning to nondisabled ranges over the study period for all participants. In contrast, walk-DMC scores demonstrated an initial acute deficit and did not reach nondisabled ranges for two of the participants, indicating persistent neurologic impairment. The findings of our pilot study show the promise of Walk-DMC's ability in identifying subtle ongoing neurologic impairment compared to traditionally used clinical assessments of balance, mobility, and function. Further work in a larger cohort of participants with traumatic brain injury will improve understanding of how walking dynamic motor control changes with injury severity and where such a measure can serve as a leading indicator of neurologic and functional recovery. CI - Copyright: (c) 2026 Aldahondo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Aldahondo, Nanette AU - Aldahondo N AUID- ORCID: 0000-0001-5484-7790 AD - Gillette Children's Specialty Healthcare, Saint Paul, Minnesota, United States of America. AD - Department of Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, Minnesota, United States of America. FAU - Ries, Andrew J AU - Ries AJ AD - James R. Gage Center for Gait and Motion Analysis, Gillette Children's Specialty Healthcare, Saint Paul, Minnesota, United States of America. AD - Department of Orthopedic Surgery, University of Minnesota, Minneapolis, Minnesota, United States of America. FAU - Schulz, Amy AU - Schulz A AD - Gillette Children's Specialty Healthcare, Saint Paul, Minnesota, United States of America. FAU - Schwartz, Michael H AU - Schwartz MH AD - James R. Gage Center for Gait and Motion Analysis, Gillette Children's Specialty Healthcare, Saint Paul, Minnesota, United States of America. AD - Department of Orthopedic Surgery, University of Minnesota, Minneapolis, Minnesota, United States of America. LA - eng PT - Journal Article DEP - 20260204 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Pilot Projects MH - *Brain Injuries, Traumatic/physiopathology/rehabilitation MH - Female MH - Male MH - Child MH - *Recovery of Function/physiology MH - *Walking/physiology MH - Adolescent MH - Postural Balance PMC - PMC12871996 COIS- The authors have declared that no competing interests exist. EDAT- 2026/02/04 19:37 MHDA- 2026/02/04 19:38 PMCR- 2026/02/04 CRDT- 2026/02/04 13:44 PHST- 2025/03/26 00:00 [received] PHST- 2025/12/18 00:00 [accepted] PHST- 2026/02/04 19:38 [medline] PHST- 2026/02/04 19:37 [pubmed] PHST- 2026/02/04 13:44 [entrez] PHST- 2026/02/04 00:00 [pmc-release] AID - PONE-D-25-14052 [pii] AID - 10.1371/journal.pone.0322674 [doi] PST - epublish SO - PLoS One. 2026 Feb 4;21(2):e0322674. doi: 10.1371/journal.pone.0322674. eCollection 2026. PMID- 41637429 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260707 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 2 DP - 2026 TI - MightyU - A portable sensor-based video game application for exercise training of children and adolescents with cerebral palsy. PG - e0339704 LID - 10.1371/journal.pone.0339704 [doi] LID - e0339704 AB - INTRODUCTION: To prevent therapy fatigue and maintain motivation for daily home muscle training is important for children with cerebral palsy (CP). Therefore, we developed the computer-based Motion-controlled training tool MightyU. Its feasibility, short-term effectiveness and acceptance of the game in daily muscle training at home was now tested in children with varying degrees of motor impairment. METHODS: A surface electromyography sensor detects muscle activation, which is translated into in-game actions. In this way, targeted muscle activity is used to collect coins during gameplay. 19 children with CP tested MightyU at home for a week on a predetermined muscle group of the upper or lower limbs. The feasibility analysis considered the number of refusals to participate in the study, voluntary use at home and feedback based on the Game Experience Questionnaire (GEQ). The evaluation of usability based on modified System Usability Scale (SUS). The training effect was assessed by analyzing the difference between collected coins before and after a one-week training. RESULTS: MightyU was refused by 2 of 21 children, 19 children (N = 9 female, 11.3 +/- 2.9 years, gross motor function classification scale GMFCS I-IV) used it at home without adverse effects. All children and their families exhibited great interest in this game independent of age, intelligence quotient, severity of disability, targeted movement, and prior experience with computer games. Key results from the GEQ were positive, yet children evaluated the gaming experience more positively to their parents across all categories. Median SUS score was 83.3% (IQR: 75.0-91.7) for children and 79.2% (IQR: 66.7-91.7) for parents, indicating good perceived usability. Training led to improvement in collecting coins (41% increase). CONCLUSION: There is a fundamental interest amongst children with CP and their families for the pioneering therapy option MightyU due to its user satisfaction and usability, thereby potentially augmenting patient autonomy and compliance. CI - Copyright: (c) 2026 Eitner et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Eitner, Lynn AU - Eitner L AUID- ORCID: 0000-0001-7143-5114 AD - Department of Neuropaediatrics, University Children's Hospital, Ruhr University Bochum, Bochum, Germany. FAU - Lucke, Lennart AU - Lucke L AUID- ORCID: 0000-0002-6325-1996 AD - Department of Neuropaediatrics, University Children's Hospital, Ruhr University Bochum, Bochum, Germany. AD - Department of Anaesthesiology and Intensive Care Medicine, Campus Charite Mitte und Charite Campus Virchow-Klinikum, Charite-Universitatsmedizin, Berlin, Germany. FAU - Farshadfar, Elnaz AU - Farshadfar E AD - Division of Physiotherapy, Bochum University of Applied Sciences, Germany. FAU - Gruneberg, Christian AU - Gruneberg C AD - Division of Physiotherapy, Bochum University of Applied Sciences, Germany. FAU - Maier, Christoph AU - Maier C AD - Department of Neuropaediatrics, University Children's Hospital, Ruhr University Bochum, Bochum, Germany. FAU - Weitkamper, Almut AU - Weitkamper A AD - Department of Neuropaediatrics, University Children's Hospital, Ruhr University Bochum, Bochum, Germany. FAU - Menzen, Bettina AU - Menzen B AD - Department of Neuropaediatrics, University Children's Hospital, Ruhr University Bochum, Bochum, Germany. FAU - Burmann, Anja AU - Burmann A AD - Fraunhofer Institute for Software and Systems Engineering ISST, Dortmund, Germany. FAU - von Gehlen, Roman AU - von Gehlen R AD - Velamed GmbH Science in Motion, Medical Technology and Biomechanical Concepts, Cologne, Germany. FAU - Konrad, Peter AU - Konrad P AD - Velamed GmbH Science in Motion, Medical Technology and Biomechanical Concepts, Cologne, Germany. FAU - Immich, Thomas AU - Immich T AD - Centigrade GmbH Saarbrucken, Germany. FAU - Karn, Britta AU - Karn B AD - Centigrade GmbH Saarbrucken, Germany. FAU - Filipowicz, Patrick AU - Filipowicz P AD - Meap GmbH Agency for Communication and Design, Witten, Germany. FAU - Pilk, Maximilian AU - Pilk M AD - Meap GmbH Agency for Communication and Design, Witten, Germany. FAU - Lucke, Thomas AU - Lucke T AD - Department of Neuropaediatrics, University Children's Hospital, Ruhr University Bochum, Bochum, Germany. LA - eng PT - Journal Article DEP - 20260204 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Cerebral Palsy/physiopathology/therapy/rehabilitation MH - Child MH - *Video Games MH - Female MH - Adolescent MH - Male MH - *Exercise Therapy/methods/instrumentation MH - Electromyography MH - *Mobile Applications PMC - PMC12872008 COIS- The authors have declared that no competing interests exist. EDAT- 2026/02/04 19:37 MHDA- 2026/02/04 19:38 PMCR- 2026/02/04 CRDT- 2026/02/04 13:34 PHST- 2024/12/28 00:00 [received] PHST- 2025/12/10 00:00 [accepted] PHST- 2026/02/04 19:38 [medline] PHST- 2026/02/04 19:37 [pubmed] PHST- 2026/02/04 13:34 [entrez] PHST- 2026/02/04 00:00 [pmc-release] AID - PONE-D-24-54773 [pii] AID - 10.1371/journal.pone.0339704 [doi] PST - epublish SO - PLoS One. 2026 Feb 4;21(2):e0339704. doi: 10.1371/journal.pone.0339704. eCollection 2026. PMID- 41635887 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260204 LR - 20260920 IS - 2516-5410 (Electronic) IS - 2096-6938 (Print) IS - 2516-5410 (Linking) VI - 9 IP - 1 DP - 2026 TI - Remote detection of the critical view of safety in pediatric laparoscopic cholecystectomy using artifitial intelligence. PG - e001125 LID - 10.1136/wjps-2025-001125 [doi] LID - e001125 AB - BACKGROUND: Laparoscopic cholecystectomy (LC) is increasingly performed in pediatric patients. Bile duct injury remains one of its most serious complications. The critical view of safety (CVS) aims to reduce this risk, but its identification is subjective. Artificial intelligence (AI) has shown promise in adult surgery for CVS detection but it has not been applied in pediatrics. Remote implementation of AI could reduce subjectivity and improve access to advanced tools. METHODS: A prospective, observational, cross-sectional, single-blind study was conducted between May and August 2025. An AI algorithm trained with 346 validated adult LC cases was tested live in 50 pediatric patients. Surgeries were transmitted in real time via teleconferencing to a second center where the algorithm processed the surgical image and identified CVS structures. Two expert surgeons, blinded to the algorithm, assessed CVS presence independently. RESULTS: A total of 50 patients (38 females and 12 males were classified as middle childhood to early adolescence) were included. The mean body mass index was 29.3+/-5.8. CVS was detected fully in 37 cases. In 13 cases, one or more elements were absent. Agreement between the algorithm and surgeons assessments was 100%. No postoperative complications were reported. CONCLUSION: Remote AI-assisted CVS detection in pediatric LC is feasible, safe and consistent with expert evaluation. CI - Copyright (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Olivieri, Sean Exequiel AU - Olivieri SE AUID- ORCID: 0009-0007-3658-0499 AD - General Surgery, Hospital General de Agudos Dr. Cosme Argerich, Buenos Aires, Argentina. AD - Digestive Surgery, Hospital de Gastroenterologia Dr. Carlos Bonorino Udaondo, Buenos Aires, Argentina. FAU - Darrigran, Santiago AU - Darrigran S AD - Pediatric Surgery, San Justo Children's Hospital, Buenos Aires, Argentina. FAU - Petracchi, Enrique AU - Petracchi E AD - General Surgery, Hospital General de Agudos Dr. Cosme Argerich, Buenos Aires, Argentina. FAU - Bidone, Paula AU - Bidone P AD - Pediatric Surgery, San Justo Children's Hospital, Buenos Aires, Argentina. FAU - Perez, Anahi AU - Perez A AD - Pediatric Surgery, San Justo Children's Hospital, Buenos Aires, Argentina. FAU - Cardozo, Leandro AU - Cardozo L AD - Pediatric Surgery, San Justo Children's Hospital, Buenos Aires, Argentina. FAU - Fernandez, Melissa AU - Fernandez M AD - Pediatric Surgery, San Justo Children's Hospital, Buenos Aires, Argentina. FAU - Zandalazini, Hugo AU - Zandalazini H AD - General Surgery, Hospital General de Agudos Dr. Cosme Argerich, Buenos Aires, Argentina. FAU - Della Pia, Ignacio AU - Della Pia I AD - Pediatric Surgery, San Justo Children's Hospital, Buenos Aires, Argentina. LA - eng PT - Journal Article DEP - 20260201 PL - England TA - World J Pediatr Surg JT - World journal of pediatric surgery JID - 101761337 PMC - PMC12863403 OTO - NOTNLM OT - Adolescent Health OT - Data Collection OT - Education, Medical OT - Evidence-Based Medicine OT - Health services research COIS- None declared. EDAT- 2026/02/04 11:33 MHDA- 2026/02/04 11:34 PMCR- 2026/02/01 CRDT- 2026/02/04 04:11 PHST- 2025/10/23 00:00 [received] PHST- 2026/01/06 00:00 [accepted] PHST- 2026/02/04 11:34 [medline] PHST- 2026/02/04 11:33 [pubmed] PHST- 2026/02/04 04:11 [entrez] PHST- 2026/02/01 00:00 [pmc-release] AID - wjps-2025-001125 [pii] AID - 10.1136/wjps-2025-001125 [doi] PST - epublish SO - World J Pediatr Surg. 2026 Feb 1;9(1):e001125. doi: 10.1136/wjps-2025-001125. eCollection 2026. PMID- 41635807 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260902 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Effect of swallowing related fatigue on eating and drinking behaviors across the age spectrum. PG - e20349 LID - 10.7717/peerj.20349 [doi] LID - e20349 AB - BACKGROUND: Swallowing related fatigue refers to the decline in swallowing efficiency and safety due to sustained muscular effort over time. It can significantly impact eating and drinking behaviors, potentially leading to aspiration, malnutrition and diminished quality of life. Understanding the effects of swallowing fatigue across the age spectrum can help guide clinical interventions and management strategies. Hence, this study aims to evaluate the effects of swallowing-related fatigue on eating and drinking behaviors in young, middle-aged and older adults. METHODS: A cross-sectional study was conducted, recruiting 400 healthy individuals divided into three groups consisting of young adults, middle-aged adults and older adults. Participants with speech, language, swallowing, neurological, or cognitive impairments were excluded. The study utilized standardized assessments, including the Swallowing and Eating-Related Fatigue Scale (SERF) to measure swallowing fatigue. Objective swallowing function was evaluated using the Timed Water Swallow Test (TWST) for liquid intake, the Test of Masticating and Swallowing Solids (TOMASS) for solid food consumption, and the Mealtime Assessment Scale (MAS) to assess overall mealtime behaviors. Video recordings of swallowing tasks were analyzed to measure efficiency, speed, and fatigue-related changes. RESULTS: Swallowing fatigue was significantly higher in older adults compared to middle-aged and young adults. TWST results showed that older adults exhibited longer swallowing durations, smaller bolus volumes per swallow, and reduced swallowing efficiency, though correlations between TWST parameters and fatigue were weak. In contrast, TOMASS scores revealed moderate associations with swallowing fatigue, as older adults took more bites, had longer mastication durations, and required more swallows per bolus. MAS scores demonstrated moderate to strong correlations with swallowing fatigue across all age groups, indicating that individuals experiencing higher fatigue levels displayed compromised mealtime efficiency and safety. Reliability analyses confirmed excellent test-retest reliability for TWST & TOMASS, with good to excellent interrater reliability. CONCLUSION: This study underscores the impact of swallowing-related fatigue on eating and drinking behaviors, particularly among older adults. While swallowing fatigue had minimal to moderate influence on TWST and TOMASS parameters respectively, MAS demonstrated stronger associations, suggesting that swallowing endurance plays a critical role in overall mealtime performance. These findings highlight the importance of integrating fatigue assessments into clinical dysphagia evaluations, as fatigue-related impairments may increase the risk of nutritional deficits and aspiration. Future research should focus on developing interventions to mitigate swallowing fatigue and improve mealtime efficiency, particularly in aging & clinical populations. CI - (c)2026 Chilwan et al. FAU - Chilwan, Uzair AU - Chilwan U AD - Department of Audiology & Speech Language Pathology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India. FAU - Kumar, K Vijaya AU - Kumar KV AD - Department of Physiotherapy, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India. FAU - Karuppali, Sudhin AU - Karuppali S AD - School of Rehabilitation and Medical Sciences, College of Health Sciences, University of Nizwa, Nizwa, Sultanate of Oman, Nizwa, Oman. FAU - Aithal, Venkataraja U AU - Aithal VU AD - Department of Speech & Hearing, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India. FAU - Balasubramanium, Radish Kumar AU - Balasubramanium RK AD - Department of Audiology & Speech Language Pathology, Kasturba Medical College Mangalore, Manipal Academy of Higher Education, Manipal, India. LA - eng PT - Journal Article DEP - 20260130 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - *Deglutition/physiology MH - *Fatigue/diagnosis/physiopathology MH - *Drinking Behavior/physiology MH - *Feeding Behavior/physiology MH - Age Factors MH - Cross-Sectional Studies MH - Aging/physiology MH - *Deglutition Disorders/complications/diagnosis/physiopathology MH - Video Recording MH - Time Factors MH - Respiratory Aspiration/etiology/physiopathology/prevention & control MH - Malnutrition/etiology/physiopathology/prevention & control MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged PMC - PMC12863145 OTO - NOTNLM OT - Drinking OT - Eating OT - Fatigue OT - Mealtime OT - Older adults OT - SERF OT - Swallowing COIS- The authors declare there are no competing interests. EDAT- 2026/02/04 11:32 MHDA- 2026/02/04 11:33 PMCR- 2026/01/30 CRDT- 2026/02/04 04:11 PHST- 2025/02/21 00:00 [received] PHST- 2025/10/15 00:00 [accepted] PHST- 2026/02/04 11:33 [medline] PHST- 2026/02/04 11:32 [pubmed] PHST- 2026/02/04 04:11 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - 20349 [pii] AID - 10.7717/peerj.20349 [doi] PST - epublish SO - PeerJ. 2026 Jan 30;14:e20349. doi: 10.7717/peerj.20349. eCollection 2026. PMID- 41635477 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260204 LR - 20260206 IS - 2471-2531 (Electronic) IS - 2471-2531 (Linking) VI - 11 IP - 2 DP - 2026 Apr TI - Resilience factors for physical activity after completion of intensive interdisciplinary pain treatment: a qualitative analysis. PG - e1400 LID - 10.1097/PR9.0000000000001400 [doi] LID - e1400 AB - OBJECTIVES: This study explored potential resilience factors that facilitate engagement in physical activity (PA) among adolescents with chronic musculoskeletal pain after completing intensive interdisciplinary pain treatment. METHODS: Ten adolescents aged 13 to 17 years with a history of chronic musculoskeletal pain from a mid-western pediatric hospital in the United States participated in this qualitative study. Participants provided demographic information and completed semistructured virtual interviews. The interviews focused on their pain experiences, resilience, and engagement in PA. Transcripts were analyzed using primarily directed content analysis based on a pain resilience framework. RESULTS: Participants highlighted several key resilience factors that influenced their PA engagement, including positive affect, motivation, acceptance, and self-efficacy. Positive affect and mood affected their willingness and enjoyment of PA. Motivation was enhanced by focusing on short-term and long-term gains and setting smaller, manageable goals. Acceptance of pain allowed participants to engage in PA even on bad pain days, using psychological flexibility skills. Social support and the ability to pair PA with other valued activities, such as spending time with friends and family, were also crucial in maintaining PA engagement. CONCLUSION: The study identified resilience factors relevant to PA interventions for pediatric chronic pain. Incorporating strategies that enhance positive affect, motivation, acceptance, and self-efficacy, along with fostering social support, may improve PA engagement and could enhance the effectiveness of PA programs, promoting better outcomes for adolescents with pain. Future research should explore and further validate the importance of these resilience factors in larger, more diverse populations and across different stages of pain treatment. CI - Copyright (c) 2026 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The International Association for the Study of Pain. FAU - Black, William R AU - Black WR AUID- ORCID: 0000-0002-1060-0187 AD - Department of Pediatrics, The Ohio State University College of Medicine, Center for Biobehavioral Health, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA. FAU - Black, Lora L AU - Black LL AD - Department of Psychiatry and Behavioral Health, The Ohio State University Wexner Medical Center, Columbus, OH, USA. FAU - Christofferson, Jennifer AU - Christofferson J AD - Department of Clinical Child Psychology, University of Kanas, Lawrence, KS, USA. FAU - Goubert, Liesbet AU - Goubert L AD - Department of Clinical Health Psychology, Gent University, Ghent, Belgium. FAU - Hoffart, Cara M AU - Hoffart CM AD - Department of Pediatrics, Children's Mercy, Kansas City, MO, USA. FAU - Wallace, Dustin P AU - Wallace DP AD - Department of Pediatrics, Children's Mercy, Kansas City, MO, USA. LA - eng PT - Journal Article DEP - 20260130 PL - United States TA - Pain Rep JT - Pain reports JID - 101683899 PMC - PMC12863838 OTO - NOTNLM OT - Pediatric pain OT - Qualitative OT - Resilience COIS- The authors have no conflicts of interest to declare.Sponsorships or competing interests that may be relevant to content are disclosed at the end of this article. EDAT- 2026/02/04 11:33 MHDA- 2026/02/04 11:34 PMCR- 2026/01/30 CRDT- 2026/02/04 04:06 PHST- 2025/05/27 00:00 [received] PHST- 2025/10/06 00:00 [revised] PHST- 2025/11/14 00:00 [accepted] PHST- 2026/02/04 11:34 [medline] PHST- 2026/02/04 11:33 [pubmed] PHST- 2026/02/04 04:06 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - PAINREPORTS-D-25-0153 [pii] AID - 10.1097/PR9.0000000000001400 [doi] PST - epublish SO - Pain Rep. 2026 Jan 30;11(2):e1400. doi: 10.1097/PR9.0000000000001400. eCollection 2026 Apr. PMID- 41635178 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 2040-1752 (Electronic) IS - 2040-1744 (Linking) VI - 17 DP - 2026 Feb 4 TI - The relationship between early life and pain among individuals with knee osteoarthritis: findings from the Hertfordshire Cohort Study. PG - e11 LID - 10.1017/S2040174425100421 [doi] AB - Studies have linked lower birth weight to development of radiographic osteoarthritis (OA). We examined early life factors in relation to subsequent knee pain among individuals with radiographic OA. 143 participants from the UK Hertfordshire Cohort study were included. Birth weight and weight at one year (WA1) were ascertained from health ledgers and used to derive conditional infant weight gain (CIWG). At baseline and follow-up, heath questionnaires (including knee pain) and knee radiographs were collected. Only those with radiographic knee OA at baseline were analysed. Logistic regression was used to examine early life factors in relation to pain. Pain at follow-up was common (men 41.3%, women 50%). Greater WA1 and greater CIWG were related to reduced risk of knee pain at follow-up after adjustment for sex and follow-up time. CIWG was protective against knee pain at follow-up, with this association attenuated after adjustment for follow-up osteophyte score. Validation in larger studies is required. FAU - Kirkham-Wilson, Fiona AU - Kirkham-Wilson F AUID- ORCID: 0009-0007-3378-1404 AD - MRC Lifecourse Epidemiology Centre, https://ror.org/01ryk1543University of Southampton, Southampton, UK. FAU - Westbury, Leo AU - Westbury L AD - MRC Lifecourse Epidemiology Centre, https://ror.org/01ryk1543University of Southampton, Southampton, UK. FAU - Fuggle, Nicholas AU - Fuggle N AD - MRC Lifecourse Epidemiology Centre, https://ror.org/01ryk1543University of Southampton, Southampton, UK. FAU - Laskou, Faidra AU - Laskou F AD - MRC Lifecourse Epidemiology Centre, https://ror.org/01ryk1543University of Southampton, Southampton, UK. FAU - Cooper, Cyrus AU - Cooper C AD - MRC Lifecourse Epidemiology Centre, https://ror.org/01ryk1543University of Southampton, Southampton, UK. FAU - Dennison, Elaine AU - Dennison E AD - MRC Lifecourse Epidemiology Centre, https://ror.org/01ryk1543University of Southampton, Southampton, UK. AD - NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, UK. AD - Victoria University of Wellington, Wellington, New Zealand. LA - eng PT - Journal Article DEP - 20260204 PL - England TA - J Dev Orig Health Dis JT - Journal of developmental origins of health and disease JID - 101517692 SB - IM MH - Humans MH - *Osteoarthritis, Knee/epidemiology/diagnostic imaging MH - Female MH - Male MH - *Pain/epidemiology/etiology MH - *Birth Weight MH - United Kingdom/epidemiology MH - *Weight Gain MH - Cohort Studies MH - Infant MH - Risk Factors MH - Radiography OTO - NOTNLM OT - Osteoarthritis OT - birth weight OT - infant weight gain OT - knee pain EDAT- 2026/02/04 11:32 MHDA- 2026/02/04 11:33 CRDT- 2026/02/04 02:43 PHST- 2026/02/04 11:33 [medline] PHST- 2026/02/04 11:32 [pubmed] PHST- 2026/02/04 02:43 [entrez] AID - S2040174425100421 [pii] AID - 10.1017/S2040174425100421 [doi] PST - epublish SO - J Dev Orig Health Dis. 2026 Feb 4;17:e11. doi: 10.1017/S2040174425100421. PMID- 41634814 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 45 IP - 1 DP - 2026 Feb 3 TI - Validity and reliability of a scale of activities of daily living at home in children, youth and adults with Down syndrome in Chile. LID - 10.1186/s41043-025-01227-0 [doi] LID - 81 AB - BACKGROUND: Activities of daily living at home (ADL) are a fundamental aspect of adaptive behavior in children, youth, and adults with Down syndrome (DS). However, they have received limited attention in relation to this topic. This highlights the lack of a validated instrument for the DS population in Chile. OBJECTIVE: a) Verify validity and reliability of the Scale for Assessing of Daily Living at Home (SAADL) and b) Develop benchmarks for daily activities in children, young people, and adults with DS in central-southern Chile. METHODS: A descriptive cross-sectional study was conducted in children, youth and adults with DS in Chile. A total of 320 young people (168 males and 152 females) with an age range of 6 to 29 years were recruited. Weight and height were assessed and body mass index BMI was calculated. The SAADL was used to measure activities of daily living at home. Reliability was determined by stability measures (test and retest) and validity by confirmatory factor analysis (CFA). Percentiles were constructed using the LMS technique (L(t) Box-Cox power, M(t) median and S(t) coefficient of variation). RESULTS: In both sexes, the technical error of measurement (TEM) showed very low values, with an absolute error of less than 0.23 and a relative error of 0.85%. The values of the concordance correlation coefficient showed high values of precision and accuracy from 0.94 to 0.98. The Kappa analysis showed substantial agreement values from 0.73 to 0.78. Mean differences in the Bland-Altman plot were minimal (~0.32 to ~0.56 points). The CFA demonstrated the validity of the scale (RMSEA: 0.057). Percentiles were plotted for SAADL (p5, p10, p15, p25, p50, p75, p85, p90 and p95). CONCLUSION: The study confirms that the SAADL is highly valid and reliable for assessing activities of daily living in children, youth and adults with DS in the south-central region of Chile. Its use is recommended as an effective tool for clinical assessment, early intervention and personalization of care, based on the proposed reference values. CI - (c) 2026. The Author(s). FAU - Cossio-Bolanos, Marco AU - Cossio-Bolanos M AD - Universidad Catolica del Maule, Talca, Chile. mcossio1972@hotmail.com. AD - Faculty of Education, Psychology and Sport Sciences, University of Huelva, Huelva, Spain. mcossio1972@hotmail.com. FAU - Vidal-Espinoza, Ruben AU - Vidal-Espinoza R AD - Universidad Catolica Silva Henriquez, Santiago, Chile. FAU - Mendez-Mendez, Liliam AU - Mendez-Mendez L AD - Universidad Catolica del Maule, Talca, Chile. FAU - Sulla-Torres, Jose AU - Sulla-Torres J AD - Universidad Catolica de Santa Maria, Arequipa, Peru. FAU - Urra-Albornoz, Camilo AU - Urra-Albornoz C AD - Departamento Ciencias de la Educacion, Facultad de Educacion y Humanidades, Universidad del Bio Bio, Chillan, Chile. FAU - Urzua-Alul, Luis AU - Urzua-Alul L AD - Escuela de Kinesiologia, Facultad de Salud, Universidad Santo Tomas, Talca, Chile. FAU - de Campos, Luis Felipe Castelli Correia AU - de Campos LFCC AD - Universidad Adventista de Chile, Chillan, Chile. FAU - Gomez-Campos, Rossana AU - Gomez-Campos R AD - Universidad Catolica del Maule, Talca, Chile. rossaunicamp@gmail.com. AD - Faculty of Education, Psychology and Sport Sciences, University of Huelva, Huelva, Spain. rossaunicamp@gmail.com. LA - eng GR - 1241104/Fondecyt Regular/ PT - Journal Article PT - Validation Study DEP - 20260203 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Humans MH - *Activities of Daily Living MH - Chile MH - Female MH - *Down Syndrome/psychology/physiopathology MH - Child MH - Male MH - Reproducibility of Results MH - Adolescent MH - Cross-Sectional Studies MH - Adult MH - Young Adult MH - Body Mass Index MH - Surveys and Questionnaires/standards PMC - PMC12955063 OTO - NOTNLM OT - Activities of daily living OT - Down sindrome OT - Psychometric properties OT - Validation COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the University Ethics Committee (UCM-65-2024). All experiments were conducted in accordance with relevant guidelines and regulations (such as the Declaration of Helsinki). Parents and guardians gave written informed consent for their children to participate in the study. All experiments were conducted in accordance with relevant guidelines and regulations (such as the Declaration of Helsinki). Competing interests: The authors declare no competing interests. EDAT- 2026/02/04 05:06 MHDA- 2026/03/07 01:37 PMCR- 2026/02/03 CRDT- 2026/02/03 23:58 PHST- 2025/05/26 00:00 [received] PHST- 2025/12/26 00:00 [accepted] PHST- 2026/03/07 01:37 [medline] PHST- 2026/02/04 05:06 [pubmed] PHST- 2026/02/03 23:58 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - 10.1186/s41043-025-01227-0 [pii] AID - 1227 [pii] AID - 10.1186/s41043-025-01227-0 [doi] PST - epublish SO - J Health Popul Nutr. 2026 Feb 3;45(1):81. doi: 10.1186/s41043-025-01227-0. PMID- 41634662 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 26 IP - 1 DP - 2026 Feb 3 TI - Cytokines and adolescent anorexia nervosa: a case-control study. LID - 10.1186/s12888-026-07874-9 [doi] LID - 223 AB - BACKGROUND: Anorexia nervosa (AN) represents a relatively common eating disorder associated with the highest mortality from all mental disorders. However, the underlying AN psychobiology remains unclear. The disruption in immune pathways seems to play an important pathophysiological role in AN. Therefore, this study aimed to evaluate the cytokine profile in association with assessing the pro-inflammatory/anti-inflammatory balance in drug-naive adolescent AN girls in the early stage of the disease. METHODS: Selected cytokines including interleukin (IL)-1alpha, IL-1beta, IL-2, IL-4, IL-6, IL-8, IL-10, interferon-gamma, tumor necrosis factor-alpha (TNF-alpha) were evaluated in 35 adolescent AN girls (mean age: 15.0 +/- 1.6 years) and 25 age-matched control adolescent girls (mean age: 15.9 +/- 1.5 years). Moreover, selected cytokine profiles and cytokine ratios were calculated to evaluate the pro-inflammatory/anti-inflammatory balance in adolescent AN. The presence and severity of depressive symptomatology were evaluated by full-filling the standardized and validated Children s Depression Inventory. RESULTS: The plasma levels of IL-1beta, IL-6, TNF-alpha, M1 profile, pro-inflammatory profile, Th1/Th2 ratio, Th1/Treg ratio, Th1/Th2 + Treg ratio, and pro-inflammatory/anti-inflammatory ratio were significantly higher in AN adolescent girls compared to controls (p = 0.002, p = 0.009, p = 0.031, p < 0.001, p = 0.042, p = 0.031, p = 0.021, p = 0.016, p = 0.001; respectively). On the other hand, the plasma level of IL-1alpha was significantly lower in AN adolescent girls compared to controls (p = 0.005). Moreover, BMI predicted levels of IL-4 and IL-1beta (p = 0.009, p = 0.046, respectively), and depressive symptomatology predicted level of IL-8 (p = 0.012) in adolescent AN girls. Lastly, ROC analysis revealed a certain predictive value of significantly changed cytokines, cytokine profiles, and ratios in adolescent AN, which markedly improved by the combination of these parameters (AUC = 0.930). Moreover, cross-validation analysis of the combined model AUC using the K-Nearest Neighbors model achieved a high overall accuracy of 0.917 for both groups, with a precision of 1.000 for the AN and 0.800 for the controls. CONCLUSIONS: Adolescent drug-naive AN in early stages of the disease is characterized by enhanced IL-1beta, IL-6, and TNF-alpha signalling indicating the activation of pro-inflammatory response system. Whether these inflammatory abnormalities are AN-specific or related to other confounding aspects of the disease still needs to be resolved, since BMI and depressive symptomatology contributed to the alterations in evaluated inflammatory markers in this study. CLINICAL TRIAL NUMBER: Not applicable. FAU - Ferencova, Nikola AU - Ferencova N AD - Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4C, Martin, Slovak Republic. AD - Biomedical Centre Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4D, Martin, Slovak Republic. FAU - Visnovcova, Zuzana AU - Visnovcova Z AD - Biomedical Centre Martin, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4D, Martin, Slovak Republic. FAU - Ondrejka, Igor AU - Ondrejka I AD - Psychiatric Clinic, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Hospital Martin, Kollarova 2, Martin, Slovak Republic. FAU - Hrtanek, Igor AU - Hrtanek I AD - Psychiatric Clinic, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Hospital Martin, Kollarova 2, Martin, Slovak Republic. FAU - Funakova, Dana AU - Funakova D AD - Psychiatric Clinic, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, University Hospital Martin, Kollarova 2, Martin, Slovak Republic. FAU - Tonhajzerova, Ingrid AU - Tonhajzerova I AD - Department of Physiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Mala Hora 4C, Martin, Slovak Republic. ingrid.tonhajzerova@uniba.sk. LA - eng GR - VEGA 1/0048/24/Ministerstvo skolstva, vedy, vyskumu a sportu Slovenskej republiky/ PT - Journal Article DEP - 20260203 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 RN - 0 (Cytokines) RN - 0 (Tumor Necrosis Factor-alpha) SB - IM MH - Humans MH - *Anorexia Nervosa/blood/immunology MH - Female MH - Adolescent MH - *Cytokines/blood MH - Case-Control Studies MH - Depression/blood MH - Tumor Necrosis Factor-alpha/blood PMC - PMC12958572 OTO - NOTNLM OT - Adolescent age OT - Anorexia nervosa OT - Cytokines OT - Depressive symptomatology OT - Pro-inflammatory/anti-inflammatory balance COIS- Declarations. Ethical approval: This study was approved by the Ethics Committee of the Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava in accordance (EK69/2018) with the Declaration of Helsinki (2000) of the World Medical Association. Consent to participate: Written informed consent to participate in the study was obtained from all participants (i.e. AN patients and controls) and their legal guardians. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/04 05:06 MHDA- 2026/06/27 06:46 PMCR- 2026/02/03 CRDT- 2026/02/03 23:49 PHST- 2025/06/20 00:00 [received] PHST- 2026/01/28 00:00 [accepted] PHST- 2026/06/27 06:46 [medline] PHST- 2026/02/04 05:06 [pubmed] PHST- 2026/02/03 23:49 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - 10.1186/s12888-026-07874-9 [pii] AID - 7874 [pii] AID - 10.1186/s12888-026-07874-9 [doi] PST - epublish SO - BMC Psychiatry. 2026 Feb 3;26(1):223. doi: 10.1186/s12888-026-07874-9. PMID- 41634640 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Feb 4 TI - School-based intervention to improve mental health, cognitive function, and academic performance in adolescents: a study protocol for a cluster randomised trial. LID - 10.1186/s12889-026-26469-3 [doi] LID - 719 AB - BACKGROUND: A majority of adolescents do not meet the recommended levels of physical activity, while reported levels of mental health problems are increasing, and socioeconomic disparities in academic performance are widening. Many schools are implementing physical activity in different forms, but there is inconclusive evidence on what types of interventions improve mental health, cognitive functions, and academic performance and how to implement such interventions. There is a critical need for integrated, feasible, and equitable interventions. The objective of this study is to develop an effective multi-component school-based intervention that will target both physical activity and homework support during an extended school day and evaluate its effects on mental health, cognitive function and academic performance. METHODS: The study is designed as a cluster-randomised controlled trial with 54 schools and approximately 2,700 students in grade 8 (age 14-15). The intervention includes three weekly 60-minute sessions: (1) Different types of physical activities (2), Homework support with short activity breaks, and (3) Walking and listening to audiobooks. This study will evaluate both outcome effects and implementation process. The primary outcome is anxiety, assessed using the Spence Children's Anxiety Scale (SCAS-S). Secondary outcomes include physical activity, sedentary time and behaviours measured by accelerometry and questionnaire, cognitive functions assessed by a computer-based test battery, mental health and sleep with questionnaires, and academic performance by grades. Process evaluation will include fidelity, dose, feasibility, acceptability and context, using structured documentation, interviews, focus groups, and observations. The effectiveness of outcomes between groups will be assessed using mixed-effects regression analysis, adjusting for relevant covariates. Process data will be analysed using descriptive statistics and content, and thematic analysis. DISCUSSION: This study addresses key knowledge gaps in school-based health promotion by integrating physical activity and homework support within the school structure. The results will yield insights into both effectiveness and implementation, informing future policy and practice in schools to promote health and facilitate students' learning. The intervention targets youth in diverse socioeconomic contexts and is expected to contribute to reducing health and education inequalities. TRIAL REGISTRATION: The trial was retrospectively registered on April 27, 2021. ISRCTN78666212. CI - (c) 2026. The Author(s). FAU - Andermo, Susanne AU - Andermo S AD - Department of Neurobiology, Care Sciences and Society, Division of Nursing, Karolinska Institutet, Huddinge, 141 83, Sweden. susanne.andermo@ki.se. AD - Department of Physical Activity and Health, The Swedish School of Sport and Health Sciences (GIH), Stockholm, 114 86, Sweden. susanne.andermo@ki.se. FAU - Helgadottir, Bjorg AU - Helgadottir B AD - Department of Physical Activity and Health, The Swedish School of Sport and Health Sciences (GIH), Stockholm, 114 86, Sweden. FAU - Vera, Lisette Farias AU - Vera LF AD - Department of Neurobiology, Care Sciences and Society, Division of Occupational Therapy, Karolinska Institutet, Huddinge, 141 83, Sweden. FAU - Ekblom, Orjan AU - Ekblom O AD - Department of Neurobiology, Care Sciences and Society, Division of Nursing, Karolinska Institutet, Huddinge, 141 83, Sweden. AD - Department of Physical Activity and Health, The Swedish School of Sport and Health Sciences (GIH), Stockholm, 114 86, Sweden. FAU - Nyberg, Gisela AU - Nyberg G AD - Department of Physical Activity and Health, The Swedish School of Sport and Health Sciences (GIH), Stockholm, 114 86, Sweden. AD - Department of Global Public Health, Karolinska Institutet, Stockholm, 171 77, Sweden. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260204 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - *Mental Health MH - *Cognition MH - *Academic Performance/statistics & numerical data MH - *School Health Services/organization & administration MH - Exercise/psychology MH - Randomized Controlled Trials as Topic MH - Female MH - Male MH - *Health Promotion/methods MH - *Students/psychology/statistics & numerical data PMC - PMC12930981 OTO - NOTNLM OT - Academic performance OT - Adolescents OT - Cognition OT - Mental health OT - Physical activity OT - Schools COIS- Declarations. Ethics approval and consent to participate: Ethical approval for this study was given by the Swedish Ethical Review Authority in Uppsala, Sweden, ref: 2021 - 00911, 2021-03586, 2023-00909-2, 2023-03241-2, 2024-01107-2. Consent to participate will be obtained from all adolescents, their parents and teachers. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/04 05:06 MHDA- 2026/02/25 10:20 PMCR- 2026/02/04 CRDT- 2026/02/03 23:48 PHST- 2025/05/23 00:00 [received] PHST- 2026/01/26 00:00 [accepted] PHST- 2026/02/25 10:20 [medline] PHST- 2026/02/04 05:06 [pubmed] PHST- 2026/02/03 23:48 [entrez] PHST- 2026/02/04 00:00 [pmc-release] AID - 10.1186/s12889-026-26469-3 [pii] AID - 26469 [pii] AID - 10.1186/s12889-026-26469-3 [doi] PST - epublish SO - BMC Public Health. 2026 Feb 4;26(1):719. doi: 10.1186/s12889-026-26469-3. PMID- 41634602 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2377 (Electronic) IS - 1471-2377 (Linking) VI - 26 IP - 1 DP - 2026 Feb 4 TI - Association of diet quality, dietary acid load and antioxidant index with migraine severity, disability, and duration: a cross-sectional study. LID - 10.1186/s12883-026-04690-2 [doi] LID - 153 AB - BACKGROUND: Migraine disproportionately affects women and may be modulated by dietary factors. This cross-sectional study investigated associations between diet quality (Alternative Healthy Eating Index, AHEI), dietary acid load (Net Endogenous Acid Production, NEAP), and dietary antioxidant capacity (Dietary Antioxidant Index, DAI) with migraine pain intensity, disability, and headache duration in Iranian women. METHODS: A total of 280 women aged 18-50 years with migraine (diagnosed per ICHD-3 criteria) were recruited from neurology clinics in Zanjan, Iran (August 2024-June 2025). Dietary intake was assessed using a validated 168-item food frequency questionnaire. AHEI, NEAP, and DAI scores were calculated and stratified into tertiles. Outcomes included pain intensity (Visual Analog Scale [VAS]: mild [1-3; reference], moderate [4-7], severe [8-10]), disability (Migraine Disability Assessment Scale [MIDAS]: none [0-5; reference], mild [6-10], moderate [11-20], severe [> 20]), and mean headache duration (hours). Multivariable-adjusted multinomial logistic regression (for VAS and MIDAS) and linear regression (for duration) were used to estimate odds ratios (ORs) and beta coefficients with 95% confidence intervals (CIs), comparing the middle (T2) and highest (T3) tertiles versus the lowest (T1; reference), adjusted for age, BMI, physical activity, prophylactic medication use, and socioeconomic status. P-for-trend was calculated using tertile medians as continuous variables. RESULTS: Higher AHEI tertiles showed graded protective associations with severe pain (T3 OR 0.69, 95% CI 0.51-0.89, p = 0.010; P-for-trend = 0.009) and shorter headache duration (T3 beta - 1.58, 95% CI - 2.75 to - 0.41, p = 0.009; P-for-trend = 0.008). Higher NEAP tertiles were linked to increased severe pain (T3 OR 1.38, 95% CI 1.08-1.66, p = 0.021; P-for-trend = 0.018), severe disability (T3 OR 1.29, 95% CI 1.02-1.56, p = 0.044; P-for-trend = 0.039), and longer duration (T3 beta 1.28, 95% CI 0.25-2.31, p = 0.015; P-for-trend = 0.013). Higher DAI tertiles demonstrated the strongest graded reductions in moderate pain (T3 OR 0.59, 95% CI 0.41-0.83, p = 0.035; P-for-trend = 0.012), severe pain (T3 OR 0.47, 95% CI 0.33-0.74, p = 0.024; P-for-trend = 0.007), moderate disability (T3 OR 0.73, 95% CI 0.52-0.97, p = 0.048; P-for-trend = 0.031), severe disability (T3 OR 0.69, 95% CI 0.47-0.91, p = 0.038; P-for-trend = 0.022), and shorter duration (T3 beta - 1.34, 95% CI - 2.33 to - 0.35, p = 0.008; P-for-trend = 0.006). CONCLUSIONS: Better diet quality and higher antioxidant capacity were associated with reduced migraine burden, while higher dietary acid load correlated with increased burden. These findings highlight potential graded associations and support the need for prospective studies to establish causality and evaluate dietary interventions in women with migraine. FAU - Hashemi, Reza AU - Hashemi R AD - Department of Pharmacy, College of Pharmacy, Knowledge University, Erbil, 44001, Iraq. FAU - Kakhki, Simin Khayatzadeh AU - Kakhki SK AD - Division of Pediatric Neurology, School of Medicine, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. FAU - Khalid, Hawzhin AU - Khalid H AD - Department of Pharmacy, College of Pharmacy, Knowledge University, Erbil, 44001, Iraq. AD - Medical Lab Technology Department, Kalar Technical College, Garmian Polytechnic University, Kifri, Sulaimaniyah, Iraq. FAU - Ghalishourani, Samira Sadat AU - Ghalishourani SS AD - Department of Physical Education and Sport Sciences, Science of Research Branch, Islamic Azad University, Tehran, Iran. FAU - Feyzpour, Marzieh AU - Feyzpour M AD - Faculty of Medical Sciences, Islamic Azad University, Science and Research Branch, Tehran, Iran. FAU - Ansari, Samaneh AU - Ansari S AD - Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. FAU - Gandomkar, Hossein AU - Gandomkar H AD - Department of Surgical Oncology, Tehran University of Medical Sciences, Tehran, Iran. samscigroup@gmail.com. FAU - Raouf, Mohammed M Hussien M AU - Raouf MMHM AD - Department of Biology, Faculty of Science and Health, Koya University, Koya, Kurdistan Region - F.R., 44023, Iraq. mohammed.m.hussein@cihanuniversity.edu.iq. LA - eng PT - Journal Article DEP - 20260204 PL - England TA - BMC Neurol JT - BMC neurology JID - 100968555 RN - 0 (Antioxidants) RN - 0 (Acids) SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - *Antioxidants/metabolism MH - *Migraine Disorders/epidemiology/physiopathology MH - Adult MH - Middle Aged MH - Iran/epidemiology MH - *Diet MH - Severity of Illness Index MH - Adolescent MH - Young Adult MH - Disability Evaluation MH - *Acids/metabolism MH - *Diet, Healthy PMC - PMC12964964 OTO - NOTNLM OT - Antioxidant index OT - Cross-Sectional study OT - Diet quality OT - Dietary acid load OT - Iran OT - Migraine OT - Women COIS- Declarations. Ethics approval and consent to participate: All methods were performed in accordance with the Declaration of Helsinki guidelines and regulations. The study protocol received approval from the Ethics Committee of Zanjan University of Medical Sciences (IR.ZUMS.REC.1403.041). Prior to participation, all individuals provided written informed consent, affirming their voluntary participation after being fully informed about the study's purpose, methodology, potential risks, and benefits. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/04 05:06 MHDA- 2026/06/27 22:35 PMCR- 2026/02/04 CRDT- 2026/02/03 23:46 PHST- 2025/10/03 00:00 [received] PHST- 2026/01/28 00:00 [accepted] PHST- 2026/06/27 22:35 [medline] PHST- 2026/02/04 05:06 [pubmed] PHST- 2026/02/03 23:46 [entrez] PHST- 2026/02/04 00:00 [pmc-release] AID - 10.1186/s12883-026-04690-2 [pii] AID - 4690 [pii] AID - 10.1186/s12883-026-04690-2 [doi] PST - epublish SO - BMC Neurol. 2026 Feb 4;26(1):153. doi: 10.1186/s12883-026-04690-2. PMID- 41634056 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Feb 3 TI - AI based sagittal spinal posture assessment for adolescent screening in low resource school settings. PG - 7076 LID - 10.1038/s41598-026-36634-8 [doi] LID - 7076 AB - Adolescent spinal postural deviations are rising across Southeast Asia, driven by prolonged screen exposure and limited access to clinical screening in low-resource environments. To address this gap, we developed PostureGuard, a low-cost AI system that provides real-time posture assessment and school-based screening support. The system incorporates a Southeast Asia-calibrated pose estimation model, benchmarked against radiographic references and validated using wearable sensor measurements. In a field deployment involving 200 students across 15 Indonesian schools, PostureGuard achieved a mean absolute error below 2.3 degrees for forward head angle estimation. We further identified a dose-response association in which each additional hour of daily screen time was associated with an estimated 2.1 degrees increase in forward head angle. A preliminary six-month school implementation suggested improvements in posture-related indicators; however, these observations were not derived from a controlled clinical trial. PostureGuard has since been piloted within Indonesia's 2024 Digital Wellness Mandate initiative. This work presents a regionally calibrated AI-based posture screening framework with clinical benchmarking and demonstrated scalability for adolescent spinal health monitoring in resource-limited settings. CI - (c) 2026. The Author(s). FAU - Rahman, Ben AU - Rahman B AD - Department of Information Systems, Universitas Nasional, Jakarta, 12520, Indonesia. benrahman@civitas.unas.ac.id. FAU - Sutedja, Indrajani AU - Sutedja I AD - Information Systems Department, School of Information Systems, Bina Nusantara University, Jakarta, 11480, Indonesia. LA - eng PT - Journal Article DEP - 20260203 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Posture/physiology MH - Schools MH - Adolescent MH - *Spine/physiology MH - *Artificial Intelligence MH - Female MH - Male MH - Indonesia MH - *Mass Screening/methods PMC - PMC12921215 OTO - NOTNLM OT - Adolescent OT - Artificial Intelligence OT - Kyphosis OT - Posture OT - Spine COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval: Not applicable. EDAT- 2026/02/04 05:06 MHDA- 2026/02/20 00:32 PMCR- 2026/02/03 CRDT- 2026/02/03 23:19 PHST- 2025/08/26 00:00 [received] PHST- 2026/01/14 00:00 [accepted] PHST- 2026/02/20 00:32 [medline] PHST- 2026/02/04 05:06 [pubmed] PHST- 2026/02/03 23:19 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - 10.1038/s41598-026-36634-8 [pii] AID - 36634 [pii] AID - 10.1038/s41598-026-36634-8 [doi] PST - epublish SO - Sci Rep. 2026 Feb 3;16(1):7076. doi: 10.1038/s41598-026-36634-8. PMID- 41632966 OWN - NLM STAT- MEDLINE DCOM- 20260707 LR - 20260827 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Feb 3 TI - Enhancing Upper Secondary Students' Situational Engagement and Cognitive Prerequisites of Learning Through the Physically Active Academic Lessons Intervention: Protocol for a Mixed Methods Cluster Randomized Individual Crossover Trial. PG - e84601 LID - 10.2196/84601 [doi] LID - e84601 AB - BACKGROUND: Internationally, physical activity is successfully integrated into academic lessons in primary schools, showing promising results on cognition and student engagement. However, there is a lack of knowledge about its effects and feasibility for individual situated learning processes in upper secondary school. OBJECTIVE: This protocol describes the design and methods of the Physically Active Academic Lessons (PAAL) study, a mixed methods, cluster randomized, individual crossover trial. The PAAL study aims to examine the acute effects of physically active academic lessons on cognitive prerequisites of learning (alertness and executive functions) and situational engagement (behavioral, cognitive, and emotional engagement; disaffection; competence experiences; and help seeking), as well as factors modifying these effects (physical and mental load and perceived physical and academic competence). Further, subject teachers' and students' experiences and perceptions of physically active academic lessons in general upper secondary school will be explored. METHODS: The first part of the PAAL study involves exploring subject teachers' experiences of facilitators, barriers, usefulness, and the meaning of physically active academic lessons for the situational learning process through semistructured interviews with 14 teachers. The second part consists of a cluster‑randomized individual crossover trial including 168 students in mathematics and foreign language lessons, followed by interviews with 30 students. RESULTS: Funding for the study was obtained in May 2023. Ethical approval for the teacher interviews was granted in September 2023, and for the student trial in December 2023. Data collection was completed between October 2023 and November 2024. Data analysis is ongoing. The findings of the study will provide essential evidence-based information on physically active classroom practices that support teachers and schools in implementing pedagogical methods that enhance student learning and well-being in upper secondary schools. CONCLUSIONS: The background, design, content of the intervention, and methods of the PAAL study are presented. This study aims to address a gap in the literature regarding the feasibility and effectiveness of physically active methods during academic lessons in upper secondary school. CI - (c) Heidi J Syvaoja, Susanna Takalo, Tuomas Kukko, Nina Salmela, Harto Hakonen, Janne Kulmala, Heidi Lindfors, Hermanni Oksanen, Pekka Rasanen, Kati Makitalo, Tuija H Tammelin. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Syvaoja, Heidi J AU - Syvaoja HJ AUID- ORCID: 0000-0002-6068-9511 AD - Likes, School of Health and Social Studies, Jamk University of Applied Sciences, Piippukatu 2, Jyvaskyla, Central Finland, FI-40100, Finland, (+358) 400248133. FAU - Takalo, Susanna AU - Takalo S AUID- ORCID: 0000-0002-9319-5446 AD - Early Childhood and Music Education Studies (CHIMES), Faculty of Education and Psychology, University of Oulu, Oulu, Finland. FAU - Kukko, Tuomas AU - Kukko T AUID- ORCID: 0000-0002-0160-1700 AD - Likes, School of Health and Social Studies, Jamk University of Applied Sciences, Piippukatu 2, Jyvaskyla, Central Finland, FI-40100, Finland, (+358) 400248133. FAU - Salmela, Nina AU - Salmela N AUID- ORCID: 0009-0002-4055-3702 AD - Learning and Learning Processes Research Unit, Faculty of Education and Psychology, University of Oulu, Oulu, Finland. AD - City of Oulu, Oulu, Finland. FAU - Hakonen, Harto AU - Hakonen H AUID- ORCID: 0000-0003-4199-3232 AD - Likes, School of Health and Social Studies, Jamk University of Applied Sciences, Piippukatu 2, Jyvaskyla, Central Finland, FI-40100, Finland, (+358) 400248133. FAU - Kulmala, Janne AU - Kulmala J AUID- ORCID: 0000-0003-0402-7983 AD - Likes, School of Health and Social Studies, Jamk University of Applied Sciences, Piippukatu 2, Jyvaskyla, Central Finland, FI-40100, Finland, (+358) 400248133. FAU - Lindfors, Heidi AU - Lindfors H AUID- ORCID: 0009-0002-3963-4206 AD - Likes, School of Health and Social Studies, Jamk University of Applied Sciences, Piippukatu 2, Jyvaskyla, Central Finland, FI-40100, Finland, (+358) 400248133. FAU - Oksanen, Hermanni AU - Oksanen H AUID- ORCID: 0009-0002-1184-5685 AD - Likes, School of Health and Social Studies, Jamk University of Applied Sciences, Piippukatu 2, Jyvaskyla, Central Finland, FI-40100, Finland, (+358) 400248133. FAU - Rasanen, Pekka AU - Rasanen P AUID- ORCID: 0000-0002-6290-3649 AD - Epilepsia Helsinki, Department of Pediatric Neurology, HUS Helsinki University Hospital, Helsinki, Finland. AD - Turku Research Institute for Learning Analytics, Faculty of Science, University of Turku, Turku, Finland. FAU - Makitalo, Kati AU - Makitalo K AUID- ORCID: 0000-0003-4037-2872 AD - Learning and Learning Processes Research Unit, Faculty of Education and Psychology, University of Oulu, Oulu, Finland. FAU - Tammelin, Tuija H AU - Tammelin TH AUID- ORCID: 0000-0002-1771-3977 AD - Likes, School of Health and Social Studies, Jamk University of Applied Sciences, Piippukatu 2, Jyvaskyla, Central Finland, FI-40100, Finland, (+358) 400248133. LA - eng SI - ISRCTN/63809854 PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260203 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Cross-Over Studies MH - *Cognition MH - *Students/psychology/statistics & numerical data MH - *Learning MH - *Exercise/psychology MH - Schools MH - Child MH - Adolescent MH - Female MH - Male PMC - PMC12867474 OTO - NOTNLM OT - acute effects OT - cluster randomized individual crossover trial OT - executive functions OT - experience OT - physically active break OT - physically active learning OT - student engagement COIS- Conflicts of Interest: None declared. EDAT- 2026/02/03 21:37 MHDA- 2026/02/03 21:38 PMCR- 2026/02/03 CRDT- 2026/02/03 16:53 PHST- 2025/10/27 00:00 [received] PHST- 2025/12/15 00:00 [revised] PHST- 2025/12/19 00:00 [accepted] PHST- 2026/02/03 21:38 [medline] PHST- 2026/02/03 21:37 [pubmed] PHST- 2026/02/03 16:53 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - v15i1e84601 [pii] AID - 84601 [pii] AID - 10.2196/84601 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Feb 3;15:e84601. doi: 10.2196/84601. PMID- 41632759 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 2 DP - 2026 TI - Assessing the validity of post-discharge readmission and mortality as a composite outcome among newborns in Uganda. PG - e0332787 LID - 10.1371/journal.pone.0332787 [doi] LID - e0332787 AB - BACKGROUND: Composite outcomes, which include mortality and readmission rates, are often used in risk prediction models following hospital discharge when event rates for the primary outcome of interest, mortality, are low. However, greater readmission rates may result in reduced mortality making interpretation of the composite outcome difficult. We assess the usefulness of a composite outcome of post-discharge readmission and mortality as a target outcome in this context. METHODS: This was a secondary analysis of data collected among mothers and their newborn(s) admitted for delivery at two regional referral hospitals in Uganda. Six-week post-discharge mortality (all-cause) and readmission in newborn infants were analyzed using a competing risk framework. The Sub distribution Hazard Ratios (SHRs) were compared across predictor variables to examine the relationship between the two outcomes. RESULTS: A total of 6040 newborns with complete six-week follow-up were enrolled, of whom 50.6% were male and 64% of mothers delivered via caesarean section. Thirty-five (0.58%) infants died within the six-week follow-up period and 241 (3.99%) were readmitted. Of the 206 predictors, 81 had a consistent association with both outcomes. These include a higher weight (SHRs: 0.14, 0.68) and length of the baby (SHRs: 0.85, 0.91). However, 125 variables depicted an association in opposing directions which may be linked to social and financial barriers to care-seeking. These include a travel time to the hospital of greater than 1 hour (SHRs: 1.4, 0.28). CONCLUSION: While mortality is unequivocally a negative outcome, readmission may be a positive outcome, reflecting health seeking, or a negative outcome, reflecting recurrent illness. This directional dichotomy is reflected to varying degrees within different variables. When using a composite outcome for a prediction model, caution should be exercised to ensure that the model identifies individuals at risk of the intended outcomes of interest, rather than merely the proxies used to represent those outcomes. Identifying predictors with a consistent relationship for both outcomes may yield a more optimized and less biased prediction model for use in clinical care. CI - Copyright: (c) 2026 Ghosh et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Ghosh, Abhroneel AU - Ghosh A AUID- ORCID: 0009-0008-3809-2189 AD - Indian Statistical Institute, Kolkata, West Bengal, India. FAU - Nguyen, Vuong AU - Nguyen V AD - Institute for Global Health, BC Children's and Women's Hospital, Vancouver, British Columbia, Canada. FAU - Ansermino, J Mark AU - Ansermino JM AD - Institute for Global Health, BC Children's and Women's Hospital, Vancouver, British Columbia, Canada. AD - Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, Canada. FAU - Pillay, Yashodani AU - Pillay Y AD - Institute for Global Health, BC Children's and Women's Hospital, Vancouver, British Columbia, Canada. AD - Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, Canada. FAU - Namala, Angella AU - Namala A AD - Jinja Regional Referral Hospital, Jinja City, Uganda. AD - Ministry of Health for the Republic of Uganda, Kampala, Uganda. FAU - Ngonzi, Joseph AU - Ngonzi J AUID- ORCID: 0000-0001-5253-9516 AD - Dept of Obstetrics and Gynaecology, Mbarara University of Science and Technology, Mbarara, Uganda. FAU - Kenya-Mugisha, Nathan AU - Kenya-Mugisha N AD - Walimu, Kampala, Uganda. FAU - Kissoon, Niranjan AU - Kissoon N AD - Institute for Global Health, BC Children's and Women's Hospital, Vancouver, British Columbia, Canada. AD - Department of Pediatrics, University of British Columbia, Vancouver, Canada. FAU - Wiens, Matthew O AU - Wiens MO AUID- ORCID: 0000-0002-3287-5181 AD - Institute for Global Health, BC Children's and Women's Hospital, Vancouver, British Columbia, Canada. AD - Department of Anesthesiology, Pharmacology & Therapeutics, University of British Columbia, Vancouver, Canada. AD - Walimu, Kampala, Uganda. LA - eng PT - Journal Article DEP - 20260203 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Uganda/epidemiology MH - *Patient Readmission/statistics & numerical data MH - Infant, Newborn MH - Female MH - *Patient Discharge/statistics & numerical data MH - Male MH - *Infant Mortality MH - Adult PMC - PMC12867235 COIS- The authors have declared that no competing interests exist. EDAT- 2026/02/03 21:35 MHDA- 2026/02/03 21:36 PMCR- 2026/02/03 CRDT- 2026/02/03 13:35 PHST- 2025/09/04 00:00 [received] PHST- 2026/01/15 00:00 [accepted] PHST- 2026/02/03 21:36 [medline] PHST- 2026/02/03 21:35 [pubmed] PHST- 2026/02/03 13:35 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - PONE-D-25-46967 [pii] AID - 10.1371/journal.pone.0332787 [doi] PST - epublish SO - PLoS One. 2026 Feb 3;21(2):e0332787. doi: 10.1371/journal.pone.0332787. eCollection 2026. PMID- 41632554 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260827 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 1 DP - 2026 Mar TI - Improving Child Malnutrition Estimates in Bangladesh: The Role of Data Quality in Anthropometric Measures Using DHS 2014-2022. PG - e70161 LID - 10.1111/mcn.70161 [doi] LID - e70161 AB - Reliable anthropometric data are essential for tracking child malnutrition, yet such data are prone to measurement errors, particularly in large-scale surveys conducted in resource-limited settings. This study assesses the quality of anthropometric data in the Bangladesh Demographic and Health Surveys (BDHS) from 2014, 2018, and 2022, focusing on how different data filtering approaches affect malnutrition estimates. We analyzed data from children aged 6-59 months using the BDHS children's recode files. Data quality was assessed using WHO-defined thresholds for biologically implausible values and SMART plausibility criteria, which exclude values beyond +/-3.1 standard deviations from the sample mean. Additional checks included z-score distribution properties, digit preference scores (DPS), and demographic consistency measures. Prevalence of stunting, underweight, and wasting was calculated before and after data filtering, with subgroup analyses by age, household wealth, and family size. SMART flagging excluded about 12% of records per round-substantially more than WHO thresholds. Stunting and underweight estimates remained broadly stable over time, while wasting prevalence dropped by 1.5-2.5 percentage points post-flagging, reflecting sensitivity of prevalence to filtering thresholds. Children aged 6-23 months were more frequently flagged. A steady decline in digit preference scores suggested improved measurement consistency, though variability persisted by socioeconomic group. Overall, BDHS anthropometric data showed stable internal patterns across survey rounds rather than conclusive reliability. These findings are presented as scenario analyses comparing WHO and SMART filters, illustrating how methodological choices influence malnutrition estimates. Strengthening field protocols-particularly for weight-for-height among younger children-could further enhance data precision and comparability. CI - (c) 2026 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Ahmed, Khandaker Tanveer AU - Ahmed KT AUID- ORCID: 0000-0001-7326-024X AD - BRAC Bank PLC, Tejgaon, Dhaka, Bangladesh. FAU - Alam, Muhammad Khairul AU - Alam MK AUID- ORCID: 0000-0002-4803-2648 AD - Department of Statistics and Data Science, Jahangirnagar University, Savar, Dhaka, Bangladesh. LA - eng PT - Journal Article PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Bangladesh/epidemiology MH - Infant MH - Child, Preschool MH - *Child Nutrition Disorders/epidemiology MH - Female MH - *Anthropometry/methods MH - Male MH - Prevalence MH - Thinness/epidemiology MH - *Data Accuracy MH - Wasting Syndrome/epidemiology MH - *Health Surveys MH - Secondary Data Analysis MH - Growth Disorders/epidemiology PMC - PMC12867088 OTO - NOTNLM OT - Bangladesh OT - DHS OT - SMART flagging OT - anthropometry OT - child nutrition OT - data quality OT - malnutrition COIS- The authors declare no conflicts of interest. EDAT- 2026/02/03 21:37 MHDA- 2026/02/03 21:38 PMCR- 2026/02/03 CRDT- 2026/02/03 12:23 PHST- 2025/10/10 00:00 [revised] PHST- 2025/05/06 00:00 [received] PHST- 2026/01/08 00:00 [accepted] PHST- 2026/02/03 21:38 [medline] PHST- 2026/02/03 21:37 [pubmed] PHST- 2026/02/03 12:23 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - MCN70161 [pii] AID - 10.1111/mcn.70161 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Mar;22(1):e70161. doi: 10.1111/mcn.70161. PMID- 41630669 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260825 IS - 2071-2936 (Electronic) IS - 2071-2928 (Print) IS - 2071-2928 (Linking) VI - 18 IP - 1 DP - 2026 Jan 15 TI - Acceptability, feasibility and equity implications of nutritional supplementation interventions for the prevention of wasting in infants and young children: A rapid qualitative evidence synthesis. PG - e1-e19 LID - 10.4102/phcfm.v18i1.5137 [doi] LID - 5137 AB - BACKGROUND: Child wasting remains a challenge despite global targets to eliminate malnutrition by 2030. While the global nutrition community has traditionally focused on treatment, a range of nutrition-specific interventions to prevent child wasting are available. AIM: To conduct a rapid qualitative evidence synthesis exploring factors influencing the acceptability, feasibility and equity of preventative interventions to inform a World Health Organization (WHO) guideline on child wasting. This manuscript reports on nutritional supplementation interventions, a subsection of the broader scope of the guideline. METHOD: We searched MEDLINE (PubMed) (database inception to 13 June 2022) for eligible studies. We coded and synthesised findings using a 'best fit' framework synthesis approach and assessed methodological quality of included studies. We presented fit-for-purpose evidence to complete qualitative evidence-to-decision criteria for the WHO recommendation. RESULTS: We included 25 articles and identified 27 themes relating to acceptability, feasibility and equity for nutritional supplementation interventions. Nutritional supplementation in children was mostly acceptable, but acceptability was mixed for other recipients. Several barriers to and facilitators of nutritional supplementation across intended recipient groups were identified, with education or information frequently emerging as facilitator. Health beliefs, as well as practical challenges, are notable barriers. Evidence on equity is sparse, but sharing practices and gender roles emerged as exacerbating factors. CONCLUSION: Nutritional supplementation interventions are probably acceptable, and there are facilitators of implementation; however, some barriers would also need to be considered. Information regarding equity was relatively sparse.Contribution: Our findings were used in drafting the WHO guideline recommendations on child wasting. FAU - Brand, Amanda S P AU - Brand ASP AD - Centre for Evidence-based Health Care, Division of Epidemiology and Biostatistics, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town. asbrand@sun.ac.za. FAU - Visser, Marianne E AU - Visser ME FAU - Kallon, Idriss I AU - Kallon II FAU - Van Wyk, Susanna S P AU - Van Wyk SSP FAU - Rohwer, Anke C AU - Rohwer AC LA - eng PT - Journal Article PT - Review DEP - 20260115 PL - South Africa TA - Afr J Prim Health Care Fam Med JT - African journal of primary health care & family medicine JID - 101520860 SB - IM MH - Humans MH - *Dietary Supplements MH - Infant MH - Child, Preschool MH - *Wasting Syndrome/prevention & control MH - Qualitative Research MH - Feasibility Studies MH - *Patient Acceptance of Health Care MH - *Child Nutrition Disorders/prevention & control PMC - PMC12869517 OTO - NOTNLM OT - acceptability OT - child wasting OT - equity OT - feasibility OT - nutrition interventions OT - qualitative evidence synthesis COIS- The authors reported that they received funding from the World Health Organization (WHO) which provided funding to Stellenbosch University and Research, Evidence and Development Initiative (READ-It), and this may be affected by the research reported in the enclosed publication. The authors have disclosed those interests fully and have implemented an approved plan for managing any potential conflicts arising from their involvement. The terms of these funding arrangements have been reviewed and approved by the affiliated university in accordance with its policy on objectivity in research. EDAT- 2026/02/03 07:40 MHDA- 2026/02/03 07:41 PMCR- 2026/01/15 CRDT- 2026/02/03 04:02 PHST- 2025/07/20 00:00 [received] PHST- 2025/11/16 00:00 [accepted] PHST- 2025/11/16 00:00 [revised] PHST- 2026/02/03 07:41 [medline] PHST- 2026/02/03 07:40 [pubmed] PHST- 2026/02/03 04:02 [entrez] PHST- 2026/01/15 00:00 [pmc-release] AID - PHCFM-18-5137 [pii] AID - 10.4102/phcfm.v18i1.5137 [doi] PST - epublish SO - Afr J Prim Health Care Fam Med. 2026 Jan 15;18(1):e1-e19. doi: 10.4102/phcfm.v18i1.5137. PMID- 41630495 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 1440-1754 (Electronic) IS - 1034-4810 (Linking) VI - 62 IP - 4 DP - 2026 Apr TI - Dietary Beliefs, Food Avoidance and Meal Skipping in Australian Children With Inflammatory Bowel Disease. PG - 579-585 LID - 10.1111/jpc.70301 [doi] AB - OBJECTIVES: To determine the frequency and patterns of dietary modification, sources of dietary advice and associated behaviours in Australian children with inflammatory bowel disease (IBD). METHODS: Mixed-methods cross-sectional study was conducted with IBD patients attending Perth Children's Hospital. Participants completed a validated questionnaire and clinical disease activity (PUCAI/PCDAI) was recorded on the day of consultation. Descriptive statistics, t-tests, chi-square tests, and multivariable logistic regressions were performed using Jamovi. RESULTS: Sixty-four children participated (34 males; mean age 13.4 +/- 2.8 years; 28 Crohn's disease, 36 ulcerative colitis). Over half (33/64, 51.6%) reported dietary modification post diagnosis, most commonly food avoidance. One-third (24/64, 37.5%) regularly skipped meals. On multivariable logistics regression food avoidance (aOR 13.8, 95% CI 2.17-87) and disease activity (aOR 12.4, 95% CI 2.80-55.1) were independently associated with meal skipping. Females were 3.17 (95% CI 1.14-8.80) times more likely to practice food avoidance and 3.56 (95% CI 1.14-8.80) times more likely to report symptom exacerbation with specific foods on univariable analysis. Although gastroenterologists and dietitians were the most trusted sources of dietary advice, over 20% (7/33) of patients were modifying their diet based on non-expert recommendation. CONCLUSIONS: Dietary modification post diagnosis is prevalent among Australian paediatric IBD patients. Meal skipping is independently associated with active disease and self-directed food avoidance; females report higher rates of food avoidance and symptoms exacerbation with foods. These findings highlight the need for proactive, consistent dietary counselling and underscore the importance of further multicentre studies to corroborate these findings. CI - (c) 2026 Paediatrics and Child Health Division (The Royal Australasian College of Physicians). FAU - Gammanpila, Dewruwan AU - Gammanpila D AUID- ORCID: 0009-0008-1036-1922 AD - Department of Gastroenterology, Perth Children's Hospital, Perth, Australia. AD - University of Western Australia, Perth, Australia. FAU - Collins, Tanya AU - Collins T AD - Nutrition and Dietetics, Perth Children's Hospital, Perth, Australia. FAU - Grover, Zubin AU - Grover Z AUID- ORCID: 0000-0002-5925-4166 AD - Department of Gastroenterology, Perth Children's Hospital, Perth, Australia. AD - University of Western Australia, Perth, Australia. LA - eng PT - Journal Article DEP - 20260202 PL - Australia TA - J Paediatr Child Health JT - Journal of paediatrics and child health JID - 9005421 SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - Cross-Sectional Studies MH - Child MH - Australia MH - *Inflammatory Bowel Diseases/psychology MH - Surveys and Questionnaires MH - *Feeding Behavior/psychology MH - Intermittent Fasting MH - *Health Knowledge, Attitudes, Practice OTO - NOTNLM OT - adolescent nutrition disorders OT - avoidant restrictive food intake disorder OT - feeding behaviour OT - food preferences OT - paediatric inflammatory bowel disease EDAT- 2026/02/03 07:40 MHDA- 2026/04/02 12:36 CRDT- 2026/02/03 02:32 PHST- 2026/01/13 00:00 [revised] PHST- 2025/11/30 00:00 [received] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/04/02 12:36 [medline] PHST- 2026/02/03 07:40 [pubmed] PHST- 2026/02/03 02:32 [entrez] AID - 10.1111/jpc.70301 [doi] PST - ppublish SO - J Paediatr Child Health. 2026 Apr;62(4):579-585. doi: 10.1111/jpc.70301. Epub 2026 Feb 2. PMID- 41630376 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260729 IS - 1538-9847 (Electronic) IS - 0029-6562 (Linking) VI - 75 IP - 4 DP - 2026 Jul-Aug 01 TI - Feasibility and Acceptability of Remote Hair Sample Collection in Parent-Child Dyads. PG - 316-321 LID - 10.1097/NNR.0000000000000892 [doi] AB - BACKGROUND: Chronic stress contributes to adverse health outcomes and may be transmitted intergenerationally. Hair cortisol concentration is a noninvasive biomarker of chronic stress; yet the feasibility and acceptability of optional remote collection in rural families remains unclear. OBJECTIVES: We evaluated the feasibility and acceptability of remote hair sample collection, identified factors associated with hair sample completion, and assessed the preliminary effects of a family-centered, mindfulness-based, motivational interviewing intervention on hair cortisol concentration. METHODS: In this pilot randomized trial, 46 rural parent-child dyads were assigned to either a remote mindfulness meditation-based motivational interviewing intervention or an active control. Hair sample collection was optional at baseline and post-intervention. Families opting in received mailed kits with written/video instructions, optional Zoom support, and a $40 incentive. Descriptive and exploratory analyses assessed participation patterns and associations with demographic and behavioral characteristics. RESULTS: Of 46 families, 36 (78%) consented to hair collection; 24 (67%) returned baseline samples, and 12 (50%) returned post-intervention samples. The average turnaround from mailing to receipt was 14 days. Participants rated instructions as clear and helpful; no families used Zoom assistance. Demographics were not significantly associated with completion, though trends indicated lower return rates among minority and full-time employed parents. At baseline, noncompleters reported higher physical activity and greater child sugary beverage intake. Nonsignificant trends also suggested that completers had more depressive symptoms and greater body fat percentage compared with noncompleters. No significant intervention effects on HCC were observed. DISCUSSIONS: Optional remote HCC collection is feasible and acceptable among many rural families, though retention declined over time. Future studies should investigate strategies to reduce barriers and promote sustained engagement when biospecimen submission is voluntary. CI - Copyright (c) 2026 Wolters Kluwer Health, Inc. All rights reserved. FAU - Kao, Tsui-Sui Annie AU - Kao TA AUID- ORCID: 0000-0002-4653-6631 AD - Tsui-Sui Annie Kao, PhD, RN, FNP-BC, FAANP and Jiying Ling, PhD, RN, FAAN, Michigan State University, College of Nursing, East Lansing, MI. FAU - Ling, Jiying AU - Ling J AUID- ORCID: 0000-0003-1997-7914 LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20260203 PL - United States TA - Nurs Res JT - Nursing research JID - 0376404 RN - WI4X0X7BPJ (Hydrocortisone) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Male MH - Feasibility Studies MH - *Hair/chemistry MH - Pilot Projects MH - *Stress, Psychological MH - Adult MH - Rural Population MH - *Motivational Interviewing/methods MH - *Hydrocortisone/analysis MH - *Parent-Child Relations MH - Child MH - Biomarkers/analysis MH - *Parents/psychology MH - Middle Aged OTO - NOTNLM OT - biomarker collection OT - chronic stress OT - parent-child dyads OT - stress physiology COIS- The authors have no conflicts of interest to report. EDAT- 2026/02/03 07:41 MHDA- 2026/06/25 00:34 CRDT- 2026/02/03 01:13 PHST- 2025/10/05 00:00 [received] PHST- 2025/12/20 00:00 [accepted] PHST- 2026/06/25 00:34 [medline] PHST- 2026/02/03 07:41 [pubmed] PHST- 2026/02/03 01:13 [entrez] AID - 00006199-990000000-00234 [pii] AID - 10.1097/NNR.0000000000000892 [doi] PST - ppublish SO - Nurs Res. 2026 Jul-Aug 01;75(4):316-321. doi: 10.1097/NNR.0000000000000892. Epub 2026 Feb 3. PMID- 41630242 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 5 DP - 2026 Jan 30 TI - Research on children's health prediction based on Improved Grey Wolf Optimization algorithm-Random Forest model. PG - e47430 LID - 10.1097/MD.0000000000047430 [doi] LID - e47430 AB - Children's health is a crucial indicator for evaluating public health standards and social development. With the changes in lifestyles and the increasing complexity of environmental factors, health issues such as childhood obesity, allergic diseases, and respiratory infections have become increasingly prominent. Traditional health assessment methods that rely on periodic physical examinations and questionnaires have limitations such as data lag and subjectivity. This paper proposes a hybrid model (IGWO-RF) that integrates the Improved Grey Wolf Optimization (IGWO) algorithm with Random Forest (RF) to enhance parameter optimization and interpretability in pediatric health prediction. Firstly, a RF prediction model is constructed based on children's physical examination data. Secondly, dynamic weight strategy and elite retention mechanisms are introduced to improve the Grey Wolf algorithm for optimizing RF hyperparameters. The model uses Shapley Additive Explanations (SHAP) values to interpret key factors affecting health. Experimental results show that the IGWO-RF model achieves an accuracy of 92.1% and a F1-score of 90.8%, which significantly outperforms the traditional RF model (85.3%) and the particle swarm optimization-RF model (88.7%). SHAP value analysis identifies body mass index (contribution value 0.32), daily exercise time (0.21), and particulate matter 2.5 exposures (0.18) as the top 3 determinants of children's health. It should be noted that these associations reflect the model's feature importance based on SHAP values and do not imply causal inference. The IGWO-RF model is potentially useful for children's health risk stratification, pending external validation, with excellent predictive performance, and its methodological framework can be extended to early warning systems for other chronic diseases after further testing. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Xu, Huan AU - Xu H AUID- ORCID: 0000-0003-1674-3557 AD - Department of Public Teaching, Hefei Preschool Education College, Hefei, China. FAU - Hu, Junying AU - Hu J AD - School of Economics and Management, Hefei University, Hefei, PR China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Random Forest MH - Humans MH - Prediction Algorithms MH - *Algorithms MH - Child MH - *Child Health MH - Body Mass Index MH - Particle Swarm Optimization MH - Soft Computing PMC - PMC12863868 OTO - NOTNLM OT - Grey Wolf Optimization OT - Random Forest OT - children's health prediction OT - healthcare analytics OT - machine learning COIS- The authors have no conflicts of interest to disclose. EDAT- 2026/02/03 07:40 MHDA- 2026/02/03 07:41 PMCR- 2026/01/30 CRDT- 2026/02/03 01:00 PHST- 2025/08/21 00:00 [received] PHST- 2025/12/17 00:00 [accepted] PHST- 2026/02/03 07:41 [medline] PHST- 2026/02/03 07:40 [pubmed] PHST- 2026/02/03 01:00 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - 00005792-202601300-00044 [pii] AID - MD-D-25-10690 [pii] AID - 10.1097/MD.0000000000047430 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jan 30;105(5):e47430. doi: 10.1097/MD.0000000000047430. PMID- 41630110 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260304 LR - 20260813 IS - 2055-5784 (Print) IS - 2055-5784 (Electronic) IS - 2055-5784 (Linking) VI - 12 IP - 1 DP - 2026 Feb 2 TI - Development and testing of a sports intervention (Girls PLAY)to promote physical activity among rural girls: a feasibility study protocol. LID - 10.1186/s40814-026-01765-2 [doi] LID - 34 AB - BACKGROUND: Few United States youth meet physical activity (PA) guidelines, with notable gender, racial/ethnic, and geographic disparities. Sport is one of the best strategies for increasing PA levels, yet girls drop out at a higher rate than boys, and both rural and Hispanic girls participate in lower numbers than their counterparts. Physical literacy (lifelong ability to move) and sport sampling (multiple sport engagement) are core elements of healthy youth sport participation. Commonly cited barriers to starting and/or sustaining sport participation include lack of competence (feeling capable), autonomy (feeling independent), and relatedness (feeling connected to others), in line with self-determination theory (SDT). Unique cultural factors also influence PA and sports participation among Hispanic girls. The proposed research aims to determine the feasibility of an out-of-school sport sampling and physical literacy intervention (Girls PLAY) on rural, Hispanic girls' PA levels. METHODS: For Aim 1, we will conduct qualitative interviews (n = 37) with rural-dwelling girls, parents, coaches, and program staff to identify sport participation determinants for rural, Hispanic girls and use these findings to inform Girls PLAY program development. For Aim 2, we will optimize the program using human-centered design (HCD) strategies such as live prototyping. Staff will implement the program for 2 weeks at a time to a program site, with feedback collected via direct observation and interviews. Feedback will inform additional program modifications. For Aim 3, we will determine the feasibility of the modified program. Staff will deliver the Girls PLAY program using SDT-based instruction at two out-of-school programs. In a sample of thirty girls, we will examine feasibility (recruitment, assessments completed, acceptability, appropriateness, attendance) and pre-post changes in PA, physical literacy, and sport participation, as well as theorized program mediators of SDT constructs. DISCUSSION: This study's innovative use of HCD strategies will help culturally tailor the Girls PLAY intervention components and ground this work in knowledge about the rural, predominantly Hispanic border populations and the contexts in which it will be delivered. This work is significant in that addressing barriers to physical activity and sport via an out-of-school program can reduce gender, racial, and geographic disparities in youth activity levels. TRIAL REGISTRATION: ClinicalTrials.gov, NCT06229457, registered January 11, 2024, https://clinicaltrials.gov/study/NCT06229457 . CI - (c) 2026. The Author(s). FAU - Johnson, Ashleigh AU - Johnson A AUID- ORCID: 0000-0001-6638-9352 AD - San Diego State University, 5500 Campanile Drive, San Diego, CA, 92182, USA. ajohnson12@sdsu.edu. FAU - Bocarro, Jason AU - Bocarro J AD - North Carolina State University, 2820 Faucette Drive, Raleigh, NC, 27606, USA. FAU - Kroshus-Havril, Emily AU - Kroshus-Havril E AD - Seattle Children's Research Institute, 1920 Terry Avenue, Seattle, WA, 98101, USA. FAU - Arredondo, Elva AU - Arredondo E AD - San Diego State University, 5500 Campanile Drive, San Diego, CA, 92182, USA. LA - eng SI - ClinicalTrials.gov/NCT06229457 GR - K01 HL171860/HL/NHLBI NIH HHS/United States GR - K01HL171860/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20260202 PL - England TA - Pilot Feasibility Stud JT - Pilot and feasibility studies JID - 101676536 PMC - PMC12955056 OTO - NOTNLM OT - Children OT - Feasibility study OT - Female OT - Physical activity OT - Rural OT - Self-determination theory OT - Youth sports COIS- Declarations. Ethics approval and consent to participate: This study was approved by the San Diego State University Institutional Review Board (HS-2023-0186) and is registered at clinicaltrials.gov (NCT06229457). Informed consent will be obtained from all participants or their parents (for children under 16) and assent will be obtained from participants under 16. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/03 07:40 MHDA- 2026/02/03 07:41 PMCR- 2026/02/02 CRDT- 2026/02/03 00:22 PHST- 2024/09/26 00:00 [received] PHST- 2026/01/13 00:00 [accepted] PHST- 2026/02/03 07:41 [medline] PHST- 2026/02/03 07:40 [pubmed] PHST- 2026/02/03 00:22 [entrez] PHST- 2026/02/02 00:00 [pmc-release] AID - 10.1186/s40814-026-01765-2 [pii] AID - 1765 [pii] AID - 10.1186/s40814-026-01765-2 [doi] PST - epublish SO - Pilot Feasibility Stud. 2026 Feb 2;12(1):34. doi: 10.1186/s40814-026-01765-2. PMID- 41629989 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Feb 2 TI - Advancing family wellbeing through a Massive Online Open Intervention: the LightBEAM program protocol for randomized waitlist control trial 1a. LID - 10.1186/s40359-025-03326-3 [doi] LID - 293 AB - While early childhood remains a formative period for healthy child development, it is simultaneously a time when parents experience increased mental health challenges. Such increased challenges (e.g., heightened parental stress, anxiety, depression, etc.) can lead to a variety of adverse child outcomes, including increased risk of externalizing and internalizing disorders. Despite the well-documented effects of parental mental health on child development, Canadian families face a plethora of barriers to accessing services in a timely manner, and as such, low-barrier, accessible mental health supports are needed. In an effort to increase available services to Canadian families, the current study translates the BEAM program (Building Emotional Awareness and Mental Health; thebeamprogram.com), a previously established online parenting and mental health app, into LightBEAM a massive open online intervention (MOOI). By translating an efficacious intervention into a MOOI format, we hope to increase accessibility, scalability, and reach of the program in an effort to better support Canadian families. To investigate the efficacy of translating BEAM into LightBEAM, a pilot waitlist control design will be utilized. Canadian families who are parenting a child between the ages of 1.5 and 8 years old and who are experiencing elevated symptoms of parenting stress, anxiety, depression, and/or anger will be recruited. When moving through the intervention arm of the trial, participants will have access to an app that houses 12 weeks of parenting and mental health videos, a group forum, and weekly exercises to reinforce key skills learned. A combination of Multilevel modeling and mediation models will be utilized to assess changes in participants' elevated mental health scores across the 12-week program and the 6-month follow-up period. Additionally, post-program focus groups will be conducted to further explore the feasibility and acceptability of the program. The translation of BEAM into LightBEAM, a national MOOI, has the potential to increase the scalability of this intervention to ensure that Canadian families have access to timely mental health and parenting supports. Results will be used to inform future iterations of the program. This trial was retrospectively registered with ClinicalTrial.gov NCT07026838 on June 10th, 20254. Protocol Version 1, August 2025 2. CI - (c) 2026. The Author(s). FAU - Sitka, Madissen AU - Sitka M AD - Department of Psychology, University of Manitoba, 190 Dysart Road, Winnipeg, MB, R3T 2N2, Canada. Madissen.Sitka@umanitoba.ca. FAU - Simpson, Kaeley M AU - Simpson KM AD - Department of Psychology, University of Manitoba, 190 Dysart Road, Winnipeg, MB, R3T 2N2, Canada. FAU - Paton, Allyson AU - Paton A AD - Department of Psychology, University of Manitoba, 190 Dysart Road, Winnipeg, MB, R3T 2N2, Canada. FAU - MacKinnon, Anna AU - MacKinnon A AD - Faculty of Medicine, Universite de Montreal, Montreal, QC, Canada. FAU - Afifi, Tracie O AU - Afifi TO AD - Rady Faculty of Community Health Sciences, University of Manitoba, Winnipeg, MB, Canada. FAU - Cameron, Emily E AU - Cameron EE AD - Faculty of Education, Simon Fraser University, Burnaby, BC, Canada. FAU - Hai, Tasmia AU - Hai T AD - Department of Psychology, University of Manitoba, 190 Dysart Road, Winnipeg, MB, R3T 2N2, Canada. FAU - Stewart-Tufescu, Ashley AU - Stewart-Tufescu A AD - Faculty of Social Work, University of Manitoba, Winnipeg, MB, Canada. FAU - Gonzalez, Andrea AU - Gonzalez A AD - Psychiatry and Behavioral Neuroscience, McMaster University, Hamilton, ON, Canada. FAU - Toombs, Elaine AU - Toombs E AD - Department of Psychology, Lakehead University, Thunder Bay, ON, Canada. FAU - Unger, Jo Ann AU - Unger JA AD - Clinical Health Psychology, University of Manitoba, Winnipeg, MB, Canada. FAU - Giuliano, Ryan AU - Giuliano R AD - Department of Psychology, University of Manitoba, 190 Dysart Road, Winnipeg, MB, R3T 2N2, Canada. FAU - Mushquash, Aislin AU - Mushquash A AD - Department of Psychology, Lakehead University, Thunder Bay, ON, Canada. FAU - Archibald, Mandy AU - Archibald M AD - Faculty of Nursing, University of Manitoba, Winnipeg, MB, Canada. FAU - Tomfohr-Madsen, Lianne AU - Tomfohr-Madsen L AD - Faculty of Education, University of British Columbia, Vancouver, BC, Canada. FAU - Roos, Leslie E AU - Roos LE AD - Department of Psychology, University of Manitoba, 190 Dysart Road, Winnipeg, MB, R3T 2N2, Canada. AD - Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada. LA - eng GR - 435-2023-0637/Social Sciences and Humanities Research Council of Canada/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20260202 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Child MH - Child, Preschool MH - Humans MH - Infant MH - Canada MH - *Family Health MH - Internet-Based Intervention MH - Mental Health MH - *Mental Health Teletherapy MH - *Mobile Applications MH - *Parenting/psychology MH - Parents/psychology MH - Randomized Controlled Trials as Topic MH - Stress, Psychological PMC - PMC12955020 OTO - NOTNLM OT - Massive Online Open Intervention (MOOI) OT - Mental health OT - Parenting COIS- Declarations. Ethics approval and consent to participate: Ethical approval was received from the University of Manitoba Research Ethics Board 1. All procedures and data collection methods will adhere to ethical guidelines. Participants will provide written to consent prior to engaging in the LightBEAM program. Furthermore, participants will be informed of their right to withdraw consent at any time throughout the study. Consent for publication: Not applicable. Competing interests: Dr. Leslie Roos and Dr. Lianne Tomfohr-Madsen are co-owners of a company that is working with the University of Manitoba to license the BEAM program for possible future use. To mitigate any conflict of interest, Dr. Roos and Dr. Tomfohr-Madsen were not directly involved in the consent process, data processing or collection. EDAT- 2026/02/03 07:41 MHDA- 2026/03/07 01:38 PMCR- 2026/02/02 CRDT- 2026/02/03 00:15 PHST- 2025/07/23 00:00 [received] PHST- 2025/08/18 00:00 [accepted] PHST- 2026/03/07 01:38 [medline] PHST- 2026/02/03 07:41 [pubmed] PHST- 2026/02/03 00:15 [entrez] PHST- 2026/02/02 00:00 [pmc-release] AID - 10.1186/s40359-025-03326-3 [pii] AID - 3326 [pii] AID - 10.1186/s40359-025-03326-3 [doi] PST - epublish SO - BMC Psychol. 2026 Feb 2;14(1):293. doi: 10.1186/s40359-025-03326-3. PMID- 41629978 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 1756-0500 (Electronic) IS - 1756-0500 (Linking) VI - 19 IP - 1 DP - 2026 Feb 2 TI - Navigating public health research in UK secondary schools: key challenges and opportunities identified by researchers. LID - 10.1186/s13104-026-07642-8 [doi] LID - 101 AB - OBJECTIVE: Conducting health research with adolescents involves navigating complex challenges at both organisational and individual levels. As part of evaluating the EACH-B (Engaging Adolescents with Changing Behaviour) intervention-a school-based randomised controlled trial aimed at improving diet and physical activity in adolescents, we explored researchers' insider experiences of programme implementation. The study investigates real-world implementation challenges and protocol adaptations in the EACH-B trial to provide practical guidance for public health interventions in schools. Applying the Consolidated Framework for Implementation Research (CFIR), data were collected through semi-structured interviews and focus groups with 10 members of the research team. RESULTS: Researchers identified significant barriers within the 'Inner' settings (internal research processes) and 'Outer' settings (external school environment and policy landscape). Research delivery was hindered by post-pandemic school priorities-specifically academic recovery and mental health support which limited the feasibility of maintaining adolescent engagement and school access. Researcher-led adaptations emerged as a critical, yet often hidden, component of maintaining trial fidelity. The study concludes that reflexive 'insider' perspectives and flexible designs are essential to align research with shifting school priorities. These adaptive strategies provide a blueprint for more resilient and feasible public health interventions. CI - (c) 2026. The Author(s). FAU - Khawaja, Laila AU - Khawaja L AD - MRC Lifecourse Epidemiology Centre, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK. Laila.Khawaja@soton.ac.uk. AD - School of Health Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK. Laila.Khawaja@soton.ac.uk. AD - NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK. Laila.Khawaja@soton.ac.uk. FAU - Muir, Sarah AU - Muir S AD - MRC Lifecourse Epidemiology Centre, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK. AD - NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK. FAU - Jenner, Sarah AU - Jenner S AD - MRC Lifecourse Epidemiology Centre, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK. AD - School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK. AD - School of Health Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK. FAU - Shaw, Sarah AU - Shaw S AD - MRC Lifecourse Epidemiology Centre, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK. AD - NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK. FAU - Barrett, Millie AU - Barrett M AD - MRC Lifecourse Epidemiology Centre, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK. FAU - Strommer, Sofia AU - Strommer S AD - MRC Lifecourse Epidemiology Centre, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK. AD - NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK. FAU - Woods-Townsend, Kath AU - Woods-Townsend K AD - NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK. AD - School of Healthcare Enterprise and Innovation, Faculty of Medicine, University of Southampton, Southampton, UK. FAU - Lovelock, Donna AU - Lovelock D AD - School of Healthcare Enterprise and Innovation, Faculty of Medicine, University of Southampton, Southampton, UK. FAU - Bagust, Lisa AU - Bagust L AD - School of Healthcare Enterprise and Innovation, Faculty of Medicine, University of Southampton, Southampton, UK. FAU - Leonard, Naomi AU - Leonard N AD - MRC Lifecourse Epidemiology Centre, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK. FAU - Lawrence, Wendy AU - Lawrence W AD - MRC Lifecourse Epidemiology Centre, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK. AD - School of Primary Care, Population Sciences, and Medical Education, Faculty of Medicine, University of Southampton, Southampton, UK. FAU - Lambrick, Danielle AU - Lambrick D AD - School of Health Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK. FAU - CPsychol, Judit Varkonyi-Sepp AU - CPsychol JV AD - School of Primary Care, Population Sciences, and Medical Education, Faculty of Medicine, University of Southampton, Southampton, UK. AD - Department of Clinical Health Psychology, Southern Health NHS Foundation Trust, Southampton, UK. FAU - Homatash, Hamid AU - Homatash H AD - Glasgow Caledonian University, Glasgow, UK. FAU - Coakley, Patricia AU - Coakley P AD - MRC Lifecourse Epidemiology Centre, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK. FAU - Vogel, Christina AU - Vogel C AD - MRC Lifecourse Epidemiology Centre, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK. AD - Centre for Food Policy, City St George's, University of London, London, UK. FAU - Morrison, Leanne AU - Morrison L AD - School of Psychology, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK. AD - School of Primary Care, Population Sciences, and Medical Education, Faculty of Medicine, University of Southampton, Southampton, UK. FAU - Horsfall, Mary Christina AU - Horsfall MC AD - MRC Lifecourse Epidemiology Centre, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK. FAU - Inskip, Hazel AU - Inskip H AD - MRC Lifecourse Epidemiology Centre, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK. FAU - Baird, Janis AU - Baird J AD - MRC Lifecourse Epidemiology Centre, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK. AD - NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust and University of Southampton, Southampton, UK. FAU - Barker, Mary AU - Barker M AD - MRC Lifecourse Epidemiology Centre, Faculty of Medicine, University of Southampton, Southampton General Hospital, Southampton, UK. AD - School of Health Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK. LA - eng PT - Journal Article DEP - 20260202 PL - England TA - BMC Res Notes JT - BMC research notes JID - 101462768 SB - IM MH - Humans MH - United Kingdom MH - *Schools MH - Adolescent MH - *Public Health MH - *Research Personnel MH - *School Health Services PMC - PMC12955064 OTO - NOTNLM OT - Adolescent health OT - CFIR OT - COVID-19 OT - Implementation science OT - Process evaluation OT - Public health OT - Researcher reflexivity OT - School-based interventions COIS- Declarations. Ethics approval and consent to participate: This study received ethical approval from the Ethics Committee (Medical), University of Southampton (ethics certificate number V3.4 11/11/22). The research was conducted in accordance with the Declaration of Helsinki. Informed consent to participate was obtained from all participants following a full explanation of the study procedures and documentation of their agreement. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/03 07:41 MHDA- 2026/03/06 19:43 PMCR- 2026/02/02 CRDT- 2026/02/03 00:14 PHST- 2025/10/06 00:00 [received] PHST- 2026/01/08 00:00 [accepted] PHST- 2026/03/06 19:43 [medline] PHST- 2026/02/03 07:41 [pubmed] PHST- 2026/02/03 00:14 [entrez] PHST- 2026/02/02 00:00 [pmc-release] AID - 10.1186/s13104-026-07642-8 [pii] AID - 7642 [pii] AID - 10.1186/s13104-026-07642-8 [doi] PST - epublish SO - BMC Res Notes. 2026 Feb 2;19(1):101. doi: 10.1186/s13104-026-07642-8. PMID- 41629834 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Feb 2 TI - The adjunctive effect of a qigong (Baduanjin) intervention program on maternal and child health outcomes: a multicenter randomized controlled trial protocol. LID - 10.1186/s12884-026-08714-0 [doi] LID - 218 AB - INTRODUCTION: Lifestyle interventions are critical for optimizing maternal and child health outcomes during pregnancy. As a mind-body exercise rooted in the principles of traditional Chinese Medicine (TCM), qigong shows promise as adaptable prenatal interventions, but the evidence is limited. OBJECTIVE: This multicenter randomized controlled trial (RCT) protocol aims to evaluate the additive effect of a qigong intervention program, compared to routine lifestyle intervention alone, on reducing the rate of caesarean section (primary outcome) and improving a range of secondary maternal and child health outcomes. METHODS: This multicenter RCT will be conducted across 11 institutions in China. A total of 1062 participants aged 18-45 years, with singleton pregnancies at 11-13(+ 6) weeks of gestation, will be enrolled and randomly allocated to two groups using a central stratified block randomization method. Participants will be randomized to either a control group receiving standard prenatal care plus evidence-based lifestyle education (encompassing nutrition, physical activity, sleep hygiene, stress management, and environmental avoidance), or an intervention group receiving all control components supplemented with supervised pregnancy-adapted qigong intervention (a modified seated Baduanjin exercise program). The primary outcome is caesarean section rate. Secondary outcomes include obstetric complications (abortion, preterm birth, gestational diabetes mellitus, gestational hypertension, postpartum hemorrhage, fetal growth restriction), neonatal indicators (birth weight, Apgar scores), maternal gestational weight gain, and mental health and sleep-related outcomes assessed through validated instruments such as Perceived Stress Scale-4 (PSS-4) for stress levels, Fear of Birth Scale (FOBS) for fear of childbirth, and Brief Pittsburgh Sleep Quality Index (B-PSQI) for sleep quality. CONCLUSION: This rigorously designed multicenter RCT protocol addresses a significant gap by investigating whether integrating the traditional mind-body practice of qigong into standard prenatal lifestyle education confers additional benefits for reducing cesarean sections and enhancing broader maternal-child health metrics. The findings will provide robust evidence on the clinical value of this TCM intervention in integrative prenatal care to improve pregnancy outcomes and maternal and child well-being. TRIAL REGISTRATION: This trial was registered at International Traditional Medicine Clinical Trial Registry, ITMCTR2025002612. CI - (c) 2026. The Author(s). FAU - Wang, Fangfang AU - Wang F AD - Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, China. AD - Institute of Medical Genetics and Development, Key Laboratory of Reproductive Genetics (Ministry of Education), Zhejiang University, Hangzhou, 310006, China. AD - Key Laboratory of Maternal and Infant Health, Hangzhou, 310006, China. AD - Linhai Branch, Women's Hospital, School of Medicine, Zhejiang University (Linhai Maternal and Child Health Hospital), Linhai, 317099, China. FAU - Zeng, Wenshan AU - Zeng W AD - Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, China. FAU - Zhou, Tianyi AU - Zhou T AD - Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, China. FAU - Yun, Feng AU - Yun F AD - Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, China. FAU - Li, Xinyue AU - Li X AD - Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, China. FAU - Li, Ying AU - Li Y AD - Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, China. FAU - Li, Hongyu AU - Li H AD - The First Affiliated Hospital (Southwest Hospital) of Army Medical University, Chongqing, 400038, China. FAU - Huang, Yinying AU - Huang Y AD - Xiamen Maternal and Child Health Hospital, Xiamen, 361003, China. FAU - Yu, Dafang AU - Yu D AD - Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, 250001, China. FAU - Guo, Shengbin AU - Guo S AD - Fujian Maternal and Child Health Hospital, Fuzhou, 350001, China. FAU - Liu, Xiao AU - Liu X AD - Jiangxi Maternal and Child Health Hospital, Nanchang, 330006, China. FAU - Hu, Chunyan AU - Hu C AD - Maternal and Child Health Hospital of Inner Mongolia Autonomous Region, Hohhot, 010020, China. FAU - Zhou, Ju AU - Zhou J AD - Dalian Women and Children's Medical Center (group), Dalian, 116012, China. FAU - Fan, Longlong AU - Fan L AD - Aksu Prefecture Maternal and Child Health Hospital, Aksu, 843000, China. FAU - Ma, Lijuan AU - Ma L AD - Linhai Branch, Women's Hospital, School of Medicine, Zhejiang University (Linhai Maternal and Child Health Hospital), Linhai, 317099, China. FAU - Yu, Guizhen AU - Yu G AD - Dongguan Maternal and Child Health Hospital, Dongguan, 523000, China. FAU - Xie, Dawei AU - Xie D AD - Department of Biostatistics, Epidemiology and Informatics, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, 227 Blockley Hall, 437 Guardian Drive, Philadelphia, PA 19104, Pennsylvania, USA. dxie@pennmedicine.upenn.edu. FAU - Xu, Xinfen AU - Xu X AD - Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, China. Xuxinf@zju.edu.cn. FAU - Qu, Fan AU - Qu F AD - Women's Hospital, School of Medicine, Zhejiang University, 1 Xueshi Road, Hangzhou, 310006, China. syqufan@zju.edu.cn. AD - Institute of Medical Genetics and Development, Key Laboratory of Reproductive Genetics (Ministry of Education), Zhejiang University, Hangzhou, 310006, China. syqufan@zju.edu.cn. AD - Key Laboratory of Maternal and Infant Health, Hangzhou, 310006, China. syqufan@zju.edu.cn. AD - Linhai Branch, Women's Hospital, School of Medicine, Zhejiang University (Linhai Maternal and Child Health Hospital), Linhai, 317099, China. syqufan@zju.edu.cn. LA - eng GR - no.2024YFC3505800/National Key Research and Development Program of China/ GR - no.81873837/National Natural Science Foundation of China/ GR - no.82575119/National Natural Science Foundation of China/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20260202 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Qigong/methods MH - Adult MH - *Prenatal Care/methods MH - Multicenter Studies as Topic MH - Randomized Controlled Trials as Topic MH - *Cesarean Section/statistics & numerical data MH - Adolescent MH - China MH - Young Adult MH - *Pregnancy Complications/prevention & control MH - Middle Aged MH - *Child Health MH - Pregnancy Outcome PMC - PMC12952147 OTO - NOTNLM OT - Clinical trial OT - Lifestyle OT - Pregnancy OT - Protocol OT - Qigong COIS- Declarations. Ethics approval and consent to participate: This research protocol has been approved by the ethics committee of Women's Hospital, School of Medicine, Zhejiang University (No. IRB-20250451-R) and registered in the International Traditional Medicine Clinical Trial Registry, ITMCTR2025002612. Consent for publication: All participants will sign the Informed Consent Form, with authorization for deidentified data sharing. Competing interests: The authors declare no competing interests. EDAT- 2026/02/03 07:41 MHDA- 2026/03/07 01:37 PMCR- 2026/02/02 CRDT- 2026/02/03 00:06 PHST- 2026/01/06 00:00 [received] PHST- 2026/01/26 00:00 [accepted] PHST- 2026/03/07 01:37 [medline] PHST- 2026/02/03 07:41 [pubmed] PHST- 2026/02/03 00:06 [entrez] PHST- 2026/02/02 00:00 [pmc-release] AID - 10.1186/s12884-026-08714-0 [pii] AID - 8714 [pii] AID - 10.1186/s12884-026-08714-0 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Feb 2;26(1):218. doi: 10.1186/s12884-026-08714-0. PMID- 41629426 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 1546-170X (Electronic) IS - 1078-8956 (Print) IS - 1078-8956 (Linking) VI - 32 IP - 2 DP - 2026 Feb TI - Implementation and evaluation of the Y-Check comprehensive adolescent health check-up intervention in Zimbabwe: a pre-post mixed-methods study. PG - 494-504 LID - 10.1038/s41591-025-04156-x [doi] AB - Routine adolescent health check-ups can support healthy development and well-being, but evidence on the feasibility, acceptability and effectiveness of contextually relevant comprehensive check-ups in low- and middle-income settings is limited. We conducted a hybrid implementation-effectiveness study incorporating a mixed-methods pre-post design of Y-Check, a comprehensive health check-up intervention in Zimbabwe, as part of a multicountry study developed and coordinated by the World Health Organization. Eligible participants were 10-19-year-old adolescents attending school or community venues. We used self-administered digital questionnaires, provider-led clinical tests and nurse reviews to screen for 25 conditions/behaviors. We provided health promotion, on-site care and referral to relevant providers. From October 2022 to September 2023, 2,097 adolescents were enrolled, of whom 1,843 (87.9%) were seen at 6 months. The primary outcome of appropriate care and/or referral(s) for all identified issues was achieved for 70.8% (95% confidence interval: 68.7-72.9%) of 1,865 participants with at least one issue. At follow-up, there were improvements in nutrition, health-related quality of life, self-esteem, behaviors and educational outcomes. The intervention was feasible and largely acceptable. Uptake of referral services varied by issue. Y-Check cost US$47 per participant. Through Y-Check, we identified untreated conditions and risk behaviors and successfully treated and linked adolescents to services. Here we provide evidence on the potential of the intervention to positively impact health and well-being. CI - (c) 2026. The Author(s). FAU - Doyle, Aoife M AU - Doyle AM AUID- ORCID: 0000-0002-3305-7738 AD - The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe. aoife.doyle@lshtm.ac.uk. AD - International Statistics & Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. aoife.doyle@lshtm.ac.uk. FAU - Nzvere, Farirai AU - Nzvere F AUID- ORCID: 0000-0002-3260-6889 AD - The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe. AD - International Statistics & Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. FAU - Manyau, Salome AU - Manyau S AD - The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe. FAU - Simms, Victoria AU - Simms V AUID- ORCID: 0000-0002-4897-458X AD - The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe. AD - International Statistics & Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. FAU - Li Lin, Ines AU - Li Lin I AD - International Statistics & Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. FAU - Kandiye, Faith R AU - Kandiye FR AD - The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe. FAU - Nyamayaro, Chipo Ashley AU - Nyamayaro CA AD - The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe. FAU - Takawira, Michaela AU - Takawira M AD - The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe. AD - Department of Global Health and Development, London School of Hygiene & Tropical Medicine, London, UK. FAU - Chingono, Rudo M S AU - Chingono RMS AD - The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe. FAU - Tembo, Mandikudza AU - Tembo M AUID- ORCID: 0000-0002-4520-3317 AD - The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe. AD - International Statistics & Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. AD - Department of Global Health and Development, London School of Hygiene & Tropical Medicine, London, UK. FAU - Manhibi, Ronald AU - Manhibi R AD - The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe. FAU - Dauya, Ethel AU - Dauya E AD - The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe. FAU - Dziva Chikwari, Chido AU - Dziva Chikwari C AD - The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe. AD - International Statistics & Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. FAU - Greco, Giulia AU - Greco G AUID- ORCID: 0000-0002-5448-9521 AD - The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe. AD - Department of Global Health and Development, London School of Hygiene & Tropical Medicine, London, UK. FAU - Bernays, Sarah AU - Bernays S AUID- ORCID: 0000-0001-7628-8408 AD - Department of Global Health and Development, London School of Hygiene & Tropical Medicine, London, UK. AD - School of Public Health, University of Sydney, Sydney, New South Wales, Australia. FAU - Baltag, Valentina AU - Baltag V AD - Adolescent and Young Adult Health Unit, Department of Maternal Newborn, Child and Adolescent Health and Ageing, World Health Organization, Geneva, Switzerland. FAU - Maisiri, Hannah AU - Maisiri H AD - Ministry of Primary and Secondary Education, Harare, Zimbabwe. FAU - Kasu, Tonderai AU - Kasu T AD - Ministry of Health and Child Care, Harare, Zimbabwe. FAU - Nyamayaro, Wenceslas AU - Nyamayaro W AD - Ministry of Health and Child Care, Harare, Zimbabwe. FAU - Bandason, Tsitsi AU - Bandason T AUID- ORCID: 0000-0003-0066-8345 AD - The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe. FAU - Mackworth-Young, Constance R S AU - Mackworth-Young CRS AD - The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe. AD - Department of Global Health and Development, London School of Hygiene & Tropical Medicine, London, UK. FAU - Banati, Prerna AU - Banati P AUID- ORCID: 0009-0003-2997-9224 AD - Adolescent and Young Adult Health Unit, Department of Maternal Newborn, Child and Adolescent Health and Ageing, World Health Organization, Geneva, Switzerland. FAU - Weiss, Helen A AU - Weiss HA AD - International Statistics & Epidemiology Group, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK. FAU - Ross, David A AU - Ross DA AUID- ORCID: 0000-0001-6353-6951 AD - Institute for Life Course Health Research, Stellenbosch University, Stellenbosch, South Africa. FAU - Ferrand, Rashida A AU - Ferrand RA AUID- ORCID: 0000-0002-7660-9176 AD - The Health Research Unit Zimbabwe, Biomedical Research and Training Institute, Harare, Zimbabwe. AD - Department of Clinical Research, London School of Hygiene & Tropical Medicine, London, UK. LA - eng GR - RG21-001/Fondation Botnar/ PT - Journal Article DEP - 20260202 PL - United States TA - Nat Med JT - Nature medicine JID - 9502015 SB - IM MH - Humans MH - Zimbabwe MH - Adolescent MH - Female MH - Male MH - Child MH - *Adolescent Health MH - *Health Promotion/methods MH - Surveys and Questionnaires MH - Young Adult MH - Referral and Consultation PMC - PMC12920085 COIS- Competing interests: The authors declare no competing interests. EDAT- 2026/02/03 00:27 MHDA- 2026/02/20 07:05 PMCR- 2026/02/02 CRDT- 2026/02/02 23:34 PHST- 2025/04/09 00:00 [received] PHST- 2025/12/02 00:00 [accepted] PHST- 2026/02/20 07:05 [medline] PHST- 2026/02/03 00:27 [pubmed] PHST- 2026/02/02 23:34 [entrez] PHST- 2026/02/02 00:00 [pmc-release] AID - 10.1038/s41591-025-04156-x [pii] AID - 4156 [pii] AID - 10.1038/s41591-025-04156-x [doi] PST - ppublish SO - Nat Med. 2026 Feb;32(2):494-504. doi: 10.1038/s41591-025-04156-x. Epub 2026 Feb 2. PMID- 41629107 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 10 IP - 1 DP - 2026 Feb 2 TI - Bone age, predicted adult height and HOMA-IR in children and adolescents with overweight and obesity: a single-centre cross-sectional study. LID - 10.1136/bmjpo-2025-003642 [doi] LID - e003642 AB - BACKGROUND: We aimed to investigate the effects of overweight and obesity on bone age (BA), predicted adult height (PAH) and glucose metabolism in children and adolescents. METHODS: Chinese boys aged 5-15 years who were overweight or obese were recruited for the study. Clinical characteristics, including height, weight, body mass index (BMI), BA, PAH and homeostatic model assessment of insulin resistance (HOMA-IR), were recorded. Spearman's rank-order correlation was used to analyse associations between BA, PAH, HOMA-IR and BMI z-scores. Receiver-operating characteristic (ROC) curves were generated to evaluate the diagnostic value of the BMI z-score. RESULTS: Data from 130 males (n=43, overweight; n=87, obese) were collected. The median BA of the cohort was significantly higher than the chronological age: 12.00 (IQR: 11.00 to 13.00) versus 10.67 (IQR: 9.50 to 12.00; p=0.000). PAH was significantly lower than mid-parental height: -0.28+/-0.81 versus 0.10+/-0.60 (p=0.000). The prevalence of BA advancement, PAH impairment and insulin resistance was 52.3% (67/128), 22.6% (28/124) and 61.3% (49/80), respectively. BA advancement and HOMA-IR positively correlated with BMI z-score (Spearman's coefficients r(s) =0.495, p=0.000 and r(s) =0.343, p=0.002, respectively). No significant association was found between PAH impairment and BMI z-score (r(s) =0.045, p=0.622). The ROC curves showed that the area under the curve for the BMI z-score of BA advancement and insulin resistance was 0.741 and 0.622, respectively. The sensitivity and specificity for BA advancement with a cut-off of 2.40 SD score (SDS) were 0.567 and 0.820, and for insulin resistance with a cut-off of 2.40 SDS, were 0.571 and 0.645. CONCLUSIONS: Approximately half of the included children had advanced BA, one-fifth of them had PAH impairment and two-thirds exhibited insulin resistance. Advanced BA and HOMA-IR were positively correlated with the BMI z-score. A BMI z-score above 2.40 SDS may indicate BA advancement and insulin resistance. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Sun, Huihui AU - Sun H AUID- ORCID: 0000-0003-3710-835X AD - Paediatrics Department, Beijing Jishuitan Hospital Affiliated to Capital Medical University, Beijing, China sunhuihui010@126.com wann6971@163.com. FAU - Wan, Naijun AU - Wan N AD - Paediatrics Department, Beijing Jishuitan Hospital Affiliated to Capital Medical University, Beijing, China sunhuihui010@126.com wann6971@163.com. LA - eng PT - Journal Article DEP - 20260202 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Male MH - Child MH - Adolescent MH - Cross-Sectional Studies MH - *Insulin Resistance MH - Child, Preschool MH - *Body Height MH - Body Mass Index MH - *Overweight/physiopathology MH - *Age Determination by Skeleton MH - ROC Curve MH - China PMC - PMC12878373 OTO - NOTNLM OT - Adolescent Health OT - Child Health OT - Endocrinology OT - Growth OT - Obesity COIS- Competing interests: None declared. EDAT- 2026/02/03 00:27 MHDA- 2026/02/03 00:28 PMCR- 2026/02/02 CRDT- 2026/02/02 21:12 PHST- 2025/05/08 00:00 [received] PHST- 2026/01/07 00:00 [accepted] PHST- 2026/02/03 00:28 [medline] PHST- 2026/02/03 00:27 [pubmed] PHST- 2026/02/02 21:12 [entrez] PHST- 2026/02/02 00:00 [pmc-release] AID - 10.1136/bmjpo-2025-003642 [pii] AID - bmjpo-2025-003642 [pii] AID - 10.1136/bmjpo-2025-003642 [doi] PST - epublish SO - BMJ Paediatr Open. 2026 Feb 2;10(1):e003642. doi: 10.1136/bmjpo-2025-003642. PMID- 41627709 OWN - NLM STAT- Publisher LR - 20260813 IS - 1532-7558 (Electronic) IS - 1070-5503 (Print) IS - 1070-5503 (Linking) DP - 2026 Feb 2 TI - Feasibility, Fidelity, and Effectiveness of an 8-week Teacher-guided Active Play Intervention: a Randomized Controlled Trial. LID - 10.1007/s12529-025-10431-5 [doi] AB - BACKGROUND: The purpose of this study was to examine the feasibility and fidelity of an 8-week teacher-guided active play intervention in an early childcare education setting. The secondary aim of this study was to examine the effects of the intervention on physical activity (PA) levels, time-on-task (TOT), and explore how teacher habit formation (automaticity) influenced implementation fidelity. METHOD: Two preschool centers were randomly assigned to the intervention (n = 27 children, 3.91 +/- 0.53 years) or the control group (n = 25 children, 3.69 +/- 0.81 years). Teachers in the intervention group delivered 15-min indoor and outdoor active play opportunities for 8 weeks. Retention measures occurred 14 weeks later. Weekly checklists and informal interviews were conducted to assess intervention fidelity. Likert-style surveys were completed by teachers each week to assess automaticity. Wrist-worn accelerometers assessed PA during the school day. A modified time sampling technique was implemented for TOT observations. RESULTS: Teacher reports indicated the intervention was relatively easy to implement. The intervention group participated in significantly greater amounts of indoor PA from baseline to post-intervention (F (1,40) = 13.59, p < 0.001, eta(p)(2) = 0.254) and from baseline to retention (F (1,33) = 16.84, p < 0.001, eta(p)(2) = 0.994) when compared to the control group. Active play opportunities did not significantly impact TOT. CONCLUSION: This study indicates that this type of intervention is feasible, particularly for indoor active play opportunities, and automaticity impacts implementation fidelity. Results of this study highlight the need to help decrease teacher barriers and increase active play during the preschool day. CI - (c) 2026. The Author(s). FAU - Spring, Katherine E AU - Spring KE AD - School of Kinesiology, Auburn University, Auburn, United States. AD - Pennington Biomedical Research Center, Baton Rouge, United States. FAU - Wadsworth, Danielle D AU - Wadsworth DD AD - School of Kinesiology, Auburn University, Auburn, United States. wadswdd@auburn.edu. LA - eng GR - T32 DK064584/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20260202 PL - England TA - Int J Behav Med JT - International journal of behavioral medicine JID - 9421097 SB - IM PMC - PMC13262602 MID - NIHMS2166898 OTO - NOTNLM OT - Automaticity OT - Childcare centers OT - Play OT - Preschool COIS- Declarations. Ethics Approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research board and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed Consent: Written informed consent (participation and publication) was obtained from all parents. Verbal assent for participation was obtained from all children. Competing Interests: The authors declare no competing interests. EDAT- 2026/02/03 00:06 MHDA- 2026/02/03 00:06 PMCR- 2026/06/12 CRDT- 2026/02/02 11:23 PHST- 2025/09/12 00:00 [received] PHST- 2025/12/18 00:00 [accepted] PHST- 2026/02/03 00:06 [medline] PHST- 2026/02/03 00:06 [pubmed] PHST- 2026/02/02 11:23 [entrez] PHST- 2026/06/12 00:00 [pmc-release] AID - 10.1007/s12529-025-10431-5 [pii] AID - 10.1007/s12529-025-10431-5 [doi] PST - aheadofprint SO - Int J Behav Med. 2026 Feb 2:10.1007/s12529-025-10431-5. doi: 10.1007/s12529-025-10431-5. PMID- 41626395 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Physical education course satisfaction scale for Chinese college students: development and psychometric properties. PG - 1717552 LID - 10.3389/fpubh.2025.1717552 [doi] LID - 1717552 AB - OBJECTIVE: The scientific community still lacks effective assessment tools for evaluating college students' PE course satisfaction. Addressing this gap will help to foster improved learning experiences and satisfaction among college students during PE course, and help achieve better health outcomes and support consistent healthy habits. Accordingly, this study aims to develop a PE course satisfaction scale for Chinese college students (PECSS-CCS). METHODS: We identified a primary scale based on a literature review and semi-structured interviews with experts. This scale were then administered to 996 Chinese students from colleges within a public university. The exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were combined to establish and verify the structural validity of PECSS-CCS. The scale's reliability was assessed through internal consistency and temporal stability tests. To assess the validity of the scale, we administered the tests of content validity, construct validity, convergent validity and criterion-related validity. And we verified measurement invariance across gender groups. RESULTS: According to EFA (N = 404), we extracted six factors namely teaching characteristics, teacher characteristics and attitudes, course experience, learning atmosphere, facilities and examination. The CFA (N = 472) fit indices results were chi(2)/df = 1.705, RMSEA = 0.039, CFI = 0.968, TLI = 0.963 and SRMR = 0.042. For the reliability, the Cronbach's alpha coefficient ranged from 0.827 to 0.924, the McDonald's omega value was 0.833 to 0.925, the composite reliability (CR) values ranged between 0.841 and 0.96, while the split-half reliability coefficient was 0.862, and the test-retest coefficient was 0.752 to 0.884 (N = 120). For the validity, the average variance explained (AVE) value ranged from 0.575 to 0.702, the PECSS-CCS subscales were positively correlated with basic psychological needs in exercise scale (BPNES), the correlation coefficient was 0.320 to 0.554. For the measurement invariance, the DeltaCFI, DeltaSRMR, and DeltaRMSEA were all under 0.010. Therefore, the main psychometric indicators of the scale had reached the satisfactory statistical standard. CONCLUSION: In summary, the PECSS-CCS, which includes 26 items, demonstrates satisfactory reliability and validity, serving as a valid assessment tool for PE course satisfaction among Chinese college students. CI - Copyright (c) 2026 Jin and Xi. FAU - Jin, Zhengcheng AU - Jin Z AD - School of Physical Education, Chongqing University of Posts and Telecommunications, Chongqing, China. FAU - Xi, Chuanhao AU - Xi C AD - College of Physical Education, China West Normal University, Nanchong, China. LA - eng PT - Journal Article DEP - 20260116 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Psychometrics MH - *Students/psychology/statistics & numerical data MH - Female MH - Universities MH - Reproducibility of Results MH - China MH - Male MH - Young Adult MH - *Physical Education and Training MH - Surveys and Questionnaires/standards MH - *Personal Satisfaction MH - Factor Analysis, Statistical MH - Adult MH - Adolescent PMC - PMC12855545 OTO - NOTNLM OT - CFA OT - EFA OT - measurement invariance OT - physical education course OT - satisfaction assessment tools COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/02 18:14 MHDA- 2026/02/02 18:15 PMCR- 2026/01/16 CRDT- 2026/02/02 07:01 PHST- 2025/10/02 00:00 [received] PHST- 2025/12/26 00:00 [revised] PHST- 2025/12/29 00:00 [accepted] PHST- 2026/02/02 18:15 [medline] PHST- 2026/02/02 18:14 [pubmed] PHST- 2026/02/02 07:01 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1717552 [doi] PST - epublish SO - Front Public Health. 2026 Jan 16;13:1717552. doi: 10.3389/fpubh.2025.1717552. eCollection 2025. PMID- 41626286 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260202 LR - 20260204 IS - 2673-6861 (Electronic) IS - 2673-6861 (Print) IS - 2673-6861 (Linking) VI - 6 DP - 2025 TI - Physical and cognitive characteristics of a group exercise program for children treated for brain tumors. PG - 1709309 LID - 10.3389/fresc.2025.1709309 [doi] LID - 1709309 AB - BACKGROUND: Children treated for brain tumor (CTBT) experience lasting physical and cognitive impairments that impact quality of life. Given the pervasive impact of brain tumor treatments on cognition, we designed a group exercise program with the specific goal of improving cognition in CTBT. A feasibility study evaluating the program demonstrated improved cognitive and physical outcomes. However, the exercises varied across sessions to maximize participant engagement throughout the 12-week program, which made it difficult to describe the program contents and identify how each element contributed to the observed improvements. OBJECTIVE: As a precursor to identifying the effective elements within the group exercise program for CTBT, this study characterized the content of our program according to the exercise categories observed in the exercise sessions, the physical fitness components within the exercises, and the cognitive demand of the exercises. METHODS: This retrospective descriptive analysis coded the content of 50 videos from the exercise program sessions by exercise category (warm-up, aerobic training, games, sports, cool-down), physical fitness components (cardiovascular, coordination, speed, agility, object control, strength, balance, flexibility), and cognitive demand (low, medium, high). Data were descriptively summarized. RESULTS: Most of the exercise session was spent on games, followed closely by sports. 33% of the exercise session involved exercises with high amounts of cardiovascular content and 46% of the exercise session involved exercises with moderate amounts of cardiovascular content. Exercises with high cognitive demand had the most coordination and object control content. Exercises with medium cognitive demand had the most cardiovascular content. CONCLUSION: The presence of exercises with either high cardiovascular content or high coordination was the hallmark of our group exercise program for CTBT. These features should be manipulated in future exercise program evaluations to determine their impact on cognitive and physical outcomes in CTBT. CI - (c) 2026 Ryan, Johnston, Bouffet, Bartels, Timmons, de Medeiros and Mabbott. FAU - Ryan, Jennifer L AU - Ryan JL AD - Neurosciences and Mental Health Program, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada. FAU - Johnston, Krista AU - Johnston K AD - Divisions of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada. FAU - Bouffet, Eric AU - Bouffet E AD - Divisions of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada. FAU - Bartels, Ute AU - Bartels U AD - Divisions of Hematology/Oncology, The Hospital for Sick Children, Toronto, ON, Canada. FAU - Timmons, Brian W AU - Timmons BW AD - Department of Pediatrics, Child Health and Exercise Medicine Program, McMaster University, Hamilton, ON, Canada. FAU - de Medeiros, Cynthia B AU - de Medeiros CB AD - Neurosciences and Mental Health Program, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada. FAU - Mabbott, Donald J AU - Mabbott DJ AD - Neurosciences and Mental Health Program, Research Institute, The Hospital for Sick Children, Toronto, ON, Canada. AD - Department of Psychology, University of Toronto, Toronto, ON, Canada. LA - eng PT - Journal Article DEP - 20260115 PL - Switzerland TA - Front Rehabil Sci JT - Frontiers in rehabilitation sciences JID - 9918227358906676 PMC - PMC12852449 OTO - NOTNLM OT - brain tumor OT - cardiovascular OT - children OT - coordination OT - exercise OT - object control COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/02 18:13 MHDA- 2026/02/02 18:14 PMCR- 2026/01/15 CRDT- 2026/02/02 07:01 PHST- 2025/09/20 00:00 [received] PHST- 2025/12/03 00:00 [revised] PHST- 2025/12/17 00:00 [accepted] PHST- 2026/02/02 18:14 [medline] PHST- 2026/02/02 18:13 [pubmed] PHST- 2026/02/02 07:01 [entrez] PHST- 2026/01/15 00:00 [pmc-release] AID - 10.3389/fresc.2025.1709309 [doi] PST - epublish SO - Front Rehabil Sci. 2026 Jan 15;6:1709309. doi: 10.3389/fresc.2025.1709309. eCollection 2025. PMID- 41625660 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260202 LR - 20260926 IS - 2277-9531 (Print) IS - 2319-6440 (Electronic) IS - 2277-9531 (Linking) VI - 14 DP - 2025 TI - Understanding the psychological impact of body weight variations: A study of weight-related body image concerns among young adults. PG - 524 LID - 10.4103/jehp.jehp_120_25 [doi] LID - 524 AB - BACKGROUND: Weight-related body image concerns significantly impact mental health and weight management in young adults (YAs) and are shaped by cultural, societal, and digital factors. Despite the prevalence of these issues, few studies have explored them in this demographic. This study utilizes a validated tool to examine key aspects of weight-related body image concerns in YAs. MATERIALS AND METHODS: A cross-sectional analytical survey was conducted using a pre-validated tool, in the outpatient settings of a tertiary healthcare in India. Snowball and purposive sampling techniques were employed, and data were analyzed using STATA/SE version 14.2. RESULTS: A total of 1071 YAs (mean age: 22.3 +/- 3.5 years) were selected, mostly from middle-income groups (61.9%) and students (63.6%), with a slight female predominance (57.1%). The prevalence of obesity was 25.2%, underweight was 11.5%, and moderate to severe body concerns were present in half of the obese (49.6%) and underweight participants (47.1%), with severe issues highest in obese YAs. Regression analysis showed increased odds of body image issues in the underweight (OR: 1.89 [1.29-2.76], P < 0.001) and obese categories (OR: 2.89 [2.18-3.83], P < 0.001). Subdomain analysis revealed that self-consciousness (P < 0.001) and lack of confidence (P < 0.001) were highest in obese YAs, while anxiety (P < 0.001), loneliness (P < 0.01), and embarrassment (P < 0.001) were highest in the underweight group. CONCLUSION: The study highlights the high prevalence of weight-related body image concerns in YAs, with underweight, overweight, and obese individuals experiencing significant distress. The findings emphasize the need for culturally tailored interventions to improve mental health in YAs with obesity. CI - Copyright: (c) 2025 Journal of Education and Health Promotion. FAU - Anwar, Wareesha AU - Anwar W AD - Department of Home Science, University of Delhi, New Delhi, India. FAU - Ranjan, Piyush AU - Ranjan P AD - Department of Medicine, All India Institute of Medical Sciences, New Delhi, India. FAU - Malhotra, Anita AU - Malhotra A AD - Department of Home Science, Lakshmibai College, University of Delhi, New Delhi, India. FAU - Kandpal, Anshul AU - Kandpal A AD - Department of Medicine, All India Institute of Medical Sciences, New Delhi, India. FAU - Upadhyay, Ashish Datt AU - Upadhyay AD AD - Clinical Research Unit, All India Institute of Medical Sciences, New Delhi, India. FAU - Kaloiya, Gauri Shanker AU - Kaloiya GS AD - Department of Psychiatry and National Drug Dependence Treatment Centre, All India Institute of Medical Sciences, New Delhi, India. FAU - Kumari, Archana AU - Kumari A AD - Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India. FAU - Vikram, Naval Kishore AU - Vikram NK AD - Department of Medicine, All India Institute of Medical Sciences, New Delhi, India. LA - eng PT - Journal Article DEP - 20251229 PL - India TA - J Educ Health Promot JT - Journal of education and health promotion JID - 101593794 PMC - PMC12854327 OTO - NOTNLM OT - Body image OT - body mass index OT - obesity OT - overweight OT - psychometrics OT - young adults OT - youth COIS- The author declares no competing interests. EDAT- 2026/02/02 18:13 MHDA- 2026/02/02 18:14 PMCR- 2025/12/29 CRDT- 2026/02/02 06:55 PHST- 2025/01/20 00:00 [received] PHST- 2025/04/23 00:00 [accepted] PHST- 2026/02/02 18:14 [medline] PHST- 2026/02/02 18:13 [pubmed] PHST- 2026/02/02 06:55 [entrez] PHST- 2025/12/29 00:00 [pmc-release] AID - JEHP-14-524 [pii] AID - 10.4103/jehp.jehp_120_25 [doi] PST - epublish SO - J Educ Health Promot. 2025 Dec 29;14:524. doi: 10.4103/jehp.jehp_120_25. eCollection 2025. PMID- 41625659 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260202 LR - 20260204 IS - 2277-9531 (Print) IS - 2319-6440 (Electronic) IS - 2277-9531 (Linking) VI - 14 DP - 2025 TI - Development and validation of Transtheoretical model-based questionnaire on micronutrients for adolescents: Psychometric properties. PG - 532 LID - 10.4103/jehp.jehp_2142_24 [doi] LID - 532 AB - BACKGROUND: The Transtheoretical model (TTM) is one of the most commonly used theories in assessing behavioral change and designing more effective interventions. The study aimed to develop and validate a questionnaire based on the TTM to assess the behavioral change of adolescent girls related to dietary micronutrient intake. MATERIALS AND METHODS: A TTM-based questionnaire (Items 36) was validated through 150 adolescent girls aged 13-18 years. The questionnaire is made on four constructs: stages of change, processes of change, self-efficacy, and decision balance. The content validity and face validity were assessed by expert panels and participants, respectively. The confirmatory factor analyses (CFA) were used to test construct validity. The Cronbach's alpha coefficient and Intraclass Correlation Coefficient (ICC) were used to analyze the internal consistency and stability of the questionnaires. RESULTS: Results showed that all content validity Index values of items in questionnaires were within the range (0.8-1). Based on face validity results, most of the items were clear, easy, and understood by participants. The CFA results included a comparative factor index of 0.99 for all constructs; a goodness of fit index ranging from 0.88 to 0.951, and a root mean square error of approximation ranging from 0.039-0.069, suggesting good model fit indices. The reliability analysis with Cronbach's alpha of 0.737-0.953 and ICCs of 0.737-0.845 was acceptable. CONCLUSION: These psychometric analysis results provided evidence for the appropriateness, reliability, and validity of the developed questionnaire. Hence, this questionnaire may help to develop customized nutrition intervention programs based on behavioral changes in the context of micronutrient intake. CI - Copyright: (c) 2025 Journal of Education and Health Promotion. FAU - Pareek, Priyanka AU - Pareek P AD - Department of Clinical Nutrition, MGM School of Biomedical Sciences, Mahatma Gandhi Mission Institute of Health Sciences (MGMIHS), Navi Mumbai, Maharashtra, India. FAU - Thorat, Aparna AU - Thorat A AD - Department of Clinical Nutrition, MGM School of Biomedical Sciences, Mahatma Gandhi Mission Institute of Health Sciences (MGMIHS), Navi Mumbai, Maharashtra, India. FAU - Chandrasekar, Chethana AU - Chandrasekar C AD - Department of Clinical Nutrition, MGM School of Biomedical Sciences, Mahatma Gandhi Mission Institute of Health Sciences (MGMIHS), Navi Mumbai, Maharashtra, India. FAU - Khanna, Poonam AU - Khanna P AD - Department of Community Medicine and School of Public Health, PGIMER, Chandigarh, India. FAU - Kulkarni, Rashmi AU - Kulkarni R AD - Department of Clinical Nutrition, MGM School of Biomedical Sciences, Mahatma Gandhi Mission Institute of Health Sciences (MGMIHS), Navi Mumbai, Maharashtra, India. FAU - Karkera, Shravya AU - Karkera S AD - Department of Clinical Nutrition, MGM School of Biomedical Sciences, Mahatma Gandhi Mission Institute of Health Sciences (MGMIHS), Navi Mumbai, Maharashtra, India. LA - eng PT - Journal Article DEP - 20251229 PL - India TA - J Educ Health Promot JT - Journal of education and health promotion JID - 101593794 PMC - PMC12854331 OTO - NOTNLM OT - Adolescent OT - micronutrients OT - reliability OT - transtheoretical model OT - validity COIS- The authors declare no conflict of interest. EDAT- 2026/02/02 18:13 MHDA- 2026/02/02 18:14 PMCR- 2025/12/29 CRDT- 2026/02/02 06:55 PHST- 2024/12/07 00:00 [received] PHST- 2025/05/06 00:00 [accepted] PHST- 2026/02/02 18:14 [medline] PHST- 2026/02/02 18:13 [pubmed] PHST- 2026/02/02 06:55 [entrez] PHST- 2025/12/29 00:00 [pmc-release] AID - JEHP-14-532 [pii] AID - 10.4103/jehp.jehp_2142_24 [doi] PST - epublish SO - J Educ Health Promot. 2025 Dec 29;14:532. doi: 10.4103/jehp.jehp_2142_24. eCollection 2025. PMID- 41625247 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 16 DP - 2025 TI - Construction and validation of a risk prediction model for metabolic syndrome: a cross-sectional study based on randomized sampling. PG - 1761342 LID - 10.3389/fendo.2025.1761342 [doi] LID - 1761342 AB - OBJECTIVE: The prevalence of metabolic syndrome is high among Chinese residents, and it is crucial to understand the current situation and intervene promptly. In this study, we investigated the current status of metabolic syndrome in some regions of China, analyzed related risk factors, and developed a risk prediction model to guide preventive measures. METHODS: A multistage stratified cluster random sampling method was used to select 3541 permanent residents aged 18-79 years from a district in Beijing for face-to-face questionnaire surveys, physical examinations, and laboratory tests. All participants were randomly divided into training and validation sets. Correlation analysis and multivariate logistic regression were employed to identify risk factors for metabolic syndrome, and a column-line graph prediction model was developed. The discriminative ability and predictive accuracy of the model were assessed by receiver operating characteristic (ROC) curve and calibration curves. RESULTS: The prevalence of metabolic syndrome in this study was 18.4%. The results of multivariate logistic regression analysis showed that increasing age, being male (OR = 1.827), being overweight (OR = 4.865), being obese (OR = 11.482), hazardous alcohol consumption (OR = 1.673), marital/cohabitation history, and specific occupations (agriculture, forestry, fisheries, and water production, and unemployed) were independent risk factors for metabolic syndrome (P < 0.05). The column-line graph prediction model, constructed accordingly, performed well, and the model indicated that BMI and age were the most significant risk factors for metabolic syndrome. The results of model validation showed that the AUCs of the training and validation sets were 0.815 (95% CI: 0.795-0.836) and 0.787 (95% CI: 0.756-0.818), respectively, indicating that the model performed well in discriminating. The model exhibited a good fit on the training set (with 1000 resamples via the Bootstrap method; calibration slope = 1.002, calibration intercept = 0.005; Hosmer-Lemeshow test, P = 0.127 > 0.05). The initial validation set showed signs of slight overfitting, and after probability calibration using the Platt Scaling method, the model's calibration performance was significantly improved (calibration slope = 0.92, calibration intercept = -0.03; Hosmer-Lemeshow test, P = 0.082 > 0.05). The Brier scores of the training set and validation set were 0.120 and 0.136, respectively, with mean absolute errors (MAE) of 0.240 and 0.256, indicating that the model had favorable predictive accuracy and stability. CONCLUSIONS: The metabolic syndrome column-line diagram risk prediction model constructed in this study, based on multivariate logistic regression analysis, has good discriminative ability and high prediction accuracy. The model shows that a large proportion of the current risk factors for metabolic syndrome are modifiable, and that the risk of metabolic syndrome in high-risk groups, such as the elderly, men, people with marital/cohabitation histories, and people with specific occupations, can be reduced through behavioral and lifestyle interventions. This model can provide a scientific basis for the early identification of high-risk groups for metabolic syndrome and has an important guiding value for targeted preventive interventions. CI - Copyright (c) 2026 Zhao, An, Liu, Meng, Liu and Mu. FAU - Zhao, Jiannan AU - Zhao J AD - Shijingshan District Center for Disease Control and Prevention, Beijing, China. FAU - An, Xinhua AU - An X AD - Wulituo Hospital of Shijingshan District, Beijing, China. FAU - Liu, Ling AU - Liu L AD - Shijingshan District Center for Disease Control and Prevention, Beijing, China. FAU - Meng, Jia AU - Meng J AD - Shijingshan District Center for Disease Control and Prevention, Beijing, China. FAU - Liu, Liyong AU - Liu L AD - Shijingshan District Center for Disease Control and Prevention, Beijing, China. FAU - Mu, Yongliang AU - Mu Y AD - Department of Vascular Surgery, Tianjin Union Medical Center, The First Affiliated Hospital of Nankai University, Tianjin, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260116 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Metabolic Syndrome/epidemiology/diagnosis/etiology MH - Male MH - Cross-Sectional Studies MH - Middle Aged MH - Risk Factors MH - China/epidemiology MH - Adult MH - Female MH - Aged MH - Adolescent MH - Young Adult MH - Prediction Algorithms MH - Prevalence MH - Logistic Models MH - Risk Assessment MH - ROC Curve MH - Surveys and Questionnaires PMC - PMC12855082 OTO - NOTNLM OT - age OT - male OT - marry OT - metabolic syndrome OT - obese OT - occupation OT - risk prediction model COIS- The authors declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/02 18:13 MHDA- 2026/02/02 18:14 PMCR- 2026/01/16 CRDT- 2026/02/02 06:51 PHST- 2025/12/05 00:00 [received] PHST- 2025/12/22 00:00 [revised] PHST- 2025/12/25 00:00 [accepted] PHST- 2026/02/02 18:14 [medline] PHST- 2026/02/02 18:13 [pubmed] PHST- 2026/02/02 06:51 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - 10.3389/fendo.2025.1761342 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Jan 16;16:1761342. doi: 10.3389/fendo.2025.1761342. eCollection 2025. PMID- 41625243 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 16 DP - 2025 TI - Risk factors for thyroid nodules in a health examination population: a cross-sectional study and development of a simplified predictive model. PG - 1738544 LID - 10.3389/fendo.2025.1738544 [doi] LID - 1738544 AB - BACKGROUND: Thyroid nodules (TNs) are common in adults and have been linked to various metabolic and demographic factors. This study aims to explore the associations between metabolic indicators and TNs in a Chinese health examination population, and to develop a simplified predictive model based on independent risk factors. METHODS: We conducted a cross-sectional analysis of 23,305 adults (12,977 men, 10,328 women; aged 18-90 years) who underwent health examinations at the Second Hospital of Hebei Medical University between January 2021 and December 2022. Exclusion criteria included prior thyroid surgery, endocrine or systemic disorders, pregnancy, and incomplete data. Demographic, lifestyle, and biochemical parameters were collected. Group differences were assessed using chi-square tests for categorical variables and t-tests or Mann-Whitney U tests for continuous variables. Univariate and multivariate logistic regression analyses were performed to identify independent risk factors, with model performance evaluated by the area under the receiver operating characteristic curve (AUC). RESULTS: The overall prevalence of TNs was 64.7% (n=15,085). The prevalence increased from 38.8% in those aged 30 years or younger to 87.8% in those older than 70 years (P for trend <0.01), and was higher in women (70.8%) compared to men (59.9%) (chi(2)=509.8, P<0.01). In multivariate analysis, older age (OR = 1.06 per year, 95% CI: 1.06-1.06, P<0.01), female sex (OR = 2.12, 95% CI: 1.93-2.32, P<0.01), and higher body mass index (OR = 1.04 per unit, 95% CI: 1.03-1.05, P<0.01) were identified as independent risk factors. The three-variable model yielded an AUC of 0.706. CONCLUSIONS: Thyroid nodules are highly prevalent in this health examination population. Age, female sex, and higher body mass index are independent risk factors. Other metabolic disturbances were more common in individuals with TNs, but they were not independent predictors. A simplified model based on age, sex, and body mass index may help identify high-risk individuals in large-scale screenings. CI - Copyright (c) 2026 Yu, Cao, Han, Li, Li, Li, Zhang and Zhang. FAU - Yu, Hangtian AU - Yu H AD - General Medical Department, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. FAU - Cao, Jingle AU - Cao J AD - General Medical Department, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. FAU - Han, Jing AU - Han J AD - General Medical Department, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. FAU - Li, Yang AU - Li Y AD - General Medical Department, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. FAU - Li, Wenyu AU - Li W AD - General Medical Department, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. FAU - Li, Zihan AU - Li Z AD - General Medical Department, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. FAU - Zhang, Jinjia AU - Zhang J AD - General Medical Department, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. FAU - Zhang, YaLi AU - Zhang Y AD - General Medical Department, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. LA - eng PT - Journal Article DEP - 20260115 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - *Thyroid Nodule/epidemiology/diagnosis/etiology MH - Female MH - Cross-Sectional Studies MH - Risk Factors MH - Male MH - Middle Aged MH - Aged, 80 and over MH - Adult MH - Aged MH - Young Adult MH - Prevalence MH - Adolescent MH - China/epidemiology PMC - PMC12852017 OTO - NOTNLM OT - body mass index OT - health examination OT - metabolic indicators OT - risk factors OT - thyroid nodules COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/02 18:13 MHDA- 2026/02/02 18:14 PMCR- 2026/01/15 CRDT- 2026/02/02 06:51 PHST- 2025/11/03 00:00 [received] PHST- 2025/12/24 00:00 [revised] PHST- 2025/12/29 00:00 [accepted] PHST- 2026/02/02 18:14 [medline] PHST- 2026/02/02 18:13 [pubmed] PHST- 2026/02/02 06:51 [entrez] PHST- 2026/01/15 00:00 [pmc-release] AID - 10.3389/fendo.2025.1738544 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Jan 15;16:1738544. doi: 10.3389/fendo.2025.1738544. eCollection 2025. PMID- 41625197 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260202 LR - 20260204 IS - 2475-2991 (Electronic) IS - 2475-2991 (Linking) VI - 10 IP - 2 DP - 2026 Feb TI - Experience and Acceptability of a Reduced-Energy Whole-Diet Intervention in Women with Gestational Diabetes: a Qualitative Study of the Dietary Intervention in Gestational Diabetes Trial. PG - 107633 LID - 10.1016/j.cdnut.2025.107633 [doi] LID - 107633 AB - BACKGROUND: Gestational diabetes mellitus (GDM) is rising in prevalence in many countries worldwide. Although dietary modifications are the first-line treatment for GDM, it is unclear which specific dietary approaches are most effective to improve maternal and offspring outcomes while reducing further maternal weight gain. We recently demonstrated benefits of an energy-restricted diet with modest weight loss in women with GDM. OBJECTIVES: We aimed to investigate the acceptability of an energy-restricted whole-diet intervention in women with GDM with a BMI >/=25 kg/m(2), in a free-living environment, and to examine potential barriers and enablers of implementation of such a diet into standard clinical care. METHODS: This qualitative research study used semistructured interviews with 20 participants in the Dietary Intervention in Gestational Diabetes trial, in which women with GDM were randomized to a whole-diet intervention containing 1200 or 2000 kcal/d. We used reflexive thematic analysis to explore participants' experiences of the study diet and GDM. RESULTS: We identified 6 key themes in participants' experience: emotional and cognitive burden of managing GDM, convenience of meal delivery, support and reassurance, hunger and appetite differences, health impacts for intervention engagement, and research participation for awareness and impact. Facilitators of study participation included support, motivation, convenience, and not wanting to be medicated. Barriers to participation were the social aspects of eating food, inconvenience, and uncertainty about the validity of dietary interventions. It was identified that participants frequently overlooked their physical health and weight management during pregnancy, despite how crucial these factors are for both maternal and infant well-being. CONCLUSIONS: Pregnant women with GDM found an energy-restricted diet to be acceptable and beneficial to emotional and physical health, especially when support is provided by healthcare professionals. The convenience of meal delivery and the motivations to avoid medication use in pregnancy facilitated engagement with the intervention.This trial was registered at ISRCTN registry as ISRCTN 65152174 (https://www.isrctn.com/ISRCTN65152174). CI - (c) 2026 The Authors. FAU - Kusinski, Laura C AU - Kusinski LC AD - Leicester Diabetes Centre and Leicester National Institute for Health and Care Research (NIHR) Biomedical Research Centre, University of Leicester, Leicester General Hospital, Leicester, United Kingdom. AD - Institute of Metabolic Science - Medical Research Laboratories, University of Cambridge, Cambridge, United Kingdom. FAU - Dib, Sarah AU - Dib S AD - Leicester Diabetes Centre and Leicester National Institute for Health and Care Research (NIHR) Biomedical Research Centre, University of Leicester, Leicester General Hospital, Leicester, United Kingdom. FAU - Smith, Suzanne AU - Smith S AD - Institute of Metabolic Science - Medical Research Laboratories, University of Cambridge, Cambridge, United Kingdom. FAU - Jones, Danielle L AU - Jones DL AD - Institute of Metabolic Science - Medical Research Laboratories, University of Cambridge, Cambridge, United Kingdom. FAU - Ahern, Amy L AU - Ahern AL AD - Medical Research Council (MRC) Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom. FAU - Meek, Claire L AU - Meek CL AD - Leicester Diabetes Centre and Leicester National Institute for Health and Care Research (NIHR) Biomedical Research Centre, University of Leicester, Leicester General Hospital, Leicester, United Kingdom. AD - Institute of Metabolic Science - Medical Research Laboratories, University of Cambridge, Cambridge, United Kingdom. AD - Cambridge Universities National Health Service Foundation Trust, Cambridge, United Kingdom. AD - University Hospitals of Leicester National Health Service Trust, Leicester General Hospital, Leicester, United Kingdom. LA - eng PT - Journal Article DEP - 20260105 PL - United States TA - Curr Dev Nutr JT - Current developments in nutrition JID - 101717957 PMC - PMC12860350 OTO - NOTNLM OT - energy restriction OT - food intervention OT - gestational diabetes OT - pregnancy OT - qualitative research COIS- The authors report no conflicts of interest. EDAT- 2026/02/02 18:13 MHDA- 2026/02/02 18:14 PMCR- 2026/01/05 CRDT- 2026/02/02 06:51 PHST- 2025/10/13 00:00 [received] PHST- 2025/12/22 00:00 [revised] PHST- 2025/12/29 00:00 [accepted] PHST- 2026/02/02 18:14 [medline] PHST- 2026/02/02 18:13 [pubmed] PHST- 2026/02/02 06:51 [entrez] PHST- 2026/01/05 00:00 [pmc-release] AID - S2475-2991(25)03095-1 [pii] AID - 107633 [pii] AID - 10.1016/j.cdnut.2025.107633 [doi] PST - epublish SO - Curr Dev Nutr. 2026 Jan 5;10(2):107633. doi: 10.1016/j.cdnut.2025.107633. eCollection 2026 Feb. PMID- 41624819 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260202 LR - 20260204 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 13 DP - 2025 TI - Parental feeding perceptions and family health behaviours: an analysis based on nutrition and physical activity tendencies. PG - 1704116 LID - 10.3389/fped.2025.1704116 [doi] LID - 1704116 AB - Childhood obesity is a growing public health concern with long-term physical and psychological consequences. Parents, as primary caregivers, play a central role in shaping children's eating habits and physical activity behaviours. This cross-sectional study examined how parental feeding perceptions and practices relate to family nutrition and physical activity patterns, and whether these associations vary according to parental demographic characteristics, particularly age. The sample comprised 268 parents of children aged 8-11 years in Turkiye, recruited from primary schools using purposive sampling. Data were collected via the Child Feeding Questionnaire (CFQ) and the Family Nutrition and Physical Activity Screening Tool (FNPA), both of which showed acceptable internal consistency in this sample. Pearson correlations, one-way ANOVA, and multiple linear regression with effect size estimates were used to analyse the data. Parental age showed no significant correlations with most CFQ subscales, except for a small negative association with restriction (r = -0.12, p < .05), indicating that older parents report slightly lower use of restrictive feeding practices. General obesity-related parental perceptions (perceived parent and child weight, concern about child's weight) were not significantly related to FNPA scores, and differences in CFQ and FNPA scores by parental gender, education level, and child age were statistically non-significant and negligible in magnitude. In contrast, FNPA scores were positively associated with parental responsibility (r = 0.32, p < .01) and monitoring (r = 0.41, p < .01). Regression analysis showed that higher responsibility and monitoring predicted more favourable family nutrition and physical activity patterns, whereas restriction was a negative predictor, with the model explaining approximately one quarter of the variance in FNPA scores. These findings underscore the importance of strengthening parental responsibility and monitoring, rather than restrictive feeding, in interventions designed to promote healthier lifestyle patterns in middle childhood. CI - (c) 2026 Orhan, Karacam, AlKasasbeh, Amawi and Canli. FAU - Orhan, Bekir Erhan AU - Orhan BE AD - Faculty of Sports Sciences, Istanbul Aydin University, Istanbul, Turkiye. FAU - Karacam, Aydin AU - Karacam A AD - Faculty of Sports Sciences, Bandirma Onyedi Eylul University, Balikesir, Turkiye. FAU - AlKasasbeh, Walaa Jumah AU - AlKasasbeh WJ AD - Department of Physical Education, School of Sport Sciences, The University of Jordan, Amman, Jordan. FAU - Amawi, Adam Tawfi AU - Amawi AT AD - Department of Movement Sciences and Sports Training, School of Sport Sciences, The University of Jordan, Amman, Jordan. FAU - Canli, Umut AU - Canli U AD - Faculty of Sports Sciences, Tekirdag Namik Kemal University, Tekirdag, Turkiye. LA - eng PT - Journal Article DEP - 20260116 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC12855539 OTO - NOTNLM OT - behaviours OT - family health OT - home environment OT - parental feeding practices OT - physical activity COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/02 18:14 MHDA- 2026/02/02 18:15 PMCR- 2026/01/16 CRDT- 2026/02/02 06:48 PHST- 2025/09/12 00:00 [received] PHST- 2025/12/24 00:00 [revised] PHST- 2025/12/30 00:00 [accepted] PHST- 2026/02/02 18:15 [medline] PHST- 2026/02/02 18:14 [pubmed] PHST- 2026/02/02 06:48 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - 10.3389/fped.2025.1704116 [doi] PST - epublish SO - Front Pediatr. 2026 Jan 16;13:1704116. doi: 10.3389/fped.2025.1704116. eCollection 2025. PMID- 41624492 OWN - NLM STAT- Publisher LR - 20260920 IS - 1748-2798 (Print) IS - 1748-2801 (Electronic) IS - 1748-2798 (Linking) DP - 2026 Jan 4 TI - Development and Validation of the Parental Media Motivations (MEMO) Scales for Child and Parent Media Use in the United States. LID - 10.1080/17482798.2025.2606976 [doi] AB - Parental motivations for their own and their child's media use may shape the quality of media experiences and ultimately child development and family well-being. However, validated scales are lacking. The current paper describes scale development and validation of the Media Motivations for Child (MEMO-C) and Parent (MEMO-P) in 501 parents with young children (2-5 years old). The MEMO-C measures motivations for children's media use, while the MEMO-P measures motivations for parents' own use, emphasizing parents' regulatory and relational goals. Each scale had a three-factor structure (MEMO-C: Regulate, Occupy, Connect; MEMO-P: Regulate, Relax Alone, Connect). These factors demonstrated strong psychometric properties including high reliability, convergent validity, and incremental validity, uniquely predicting child- and parent-related constructs. By measuring parental media motivations through a regulatory and relational lens, these scales enable researchers to more closely examine how family media use is associated with child development and family members' well-being. FAU - Suh, Bolim AU - Suh B AUID- ORCID: 0000-0001-9743-526X AD - University of Wisconsin-Madison, Madison, United States. FAU - Barr, Rachel AU - Barr R AUID- ORCID: 0000-0002-5855-9718 AD - Georgetown University, Washington, United States. FAU - Kerr, Margaret L AU - Kerr ML AUID- ORCID: 0000-0002-1398-4083 AD - University of Wisconsin-Madison, Madison, United States. FAU - Radesky, Jenny AU - Radesky J AUID- ORCID: 0000-0002-7721-7350 AD - University of Michigan, Ann Arbor, USA. FAU - Kirkorian, Heather AU - Kirkorian H AUID- ORCID: 0000-0002-7990-7777 AD - University of Wisconsin-Madison, Madison, United States. LA - eng GR - P01 HD109907/HD/NICHD NIH HHS/United States PT - Journal Article DEP - 20260104 PL - England TA - J Child Media JT - Journal of children and media JID - 101318681 PMC - PMC12854708 MID - NIHMS2141034 OTO - NOTNLM OT - family media ecology OT - parental media motivation OT - regulatory media use OT - screen time OT - uses and gratifications COIS- Disclosure statement The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/02 18:13 MHDA- 2026/02/02 18:13 PMCR- 2026/01/30 CRDT- 2026/02/02 06:46 PHST- 2026/02/02 18:13 [medline] PHST- 2026/02/02 18:13 [pubmed] PHST- 2026/02/02 06:46 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - 10.1080/17482798.2025.2606976 [doi] PST - aheadofprint SO - J Child Media. 2026 Jan 4:10.1080/17482798.2025.2606976. doi: 10.1080/17482798.2025.2606976. PMID- 41624364 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260202 LR - 20260204 IS - 0974-7052 (Print) IS - 0975-1904 (Electronic) IS - 0974-7052 (Linking) VI - 19 IP - 1 DP - 2026 Jan TI - Effectiveness of Pomegranate as a Dietary Intervention for Early Childhood Caries Prevention: A Randomized Control Trial. PG - 47-54 LID - 10.5005/jp-journals-10005-3397 [doi] AB - BACKGROUND: Early childhood caries (ECC) is a significant public health issue that require effective preventive strategies. Pomegranate, rich in antimicrobial and antioxidant properties, has been proposed as a dietary intervention for ECC prevention. AIM: To assess the effectiveness of pomegranate in reducing ECC, improving salivary pH, and enhancing oral health over 12 months. MATERIALS AND METHODS: This randomized controlled study included 500 children aged 3-6 years, who were divided into intervention and control groups. The intervention group consumed pomegranate extract, while the control group received standard oral hygiene education. Dental examinations assessed Decayed, Missing, and Filled Teeth (DMFT) scores and salivary pH at baseline, 6 months, and 12 months. Statistical analyses included paired and unpaired t-tests for intragroup and intergroup comparisons, analysis of variance (ANOVA) for repeated measures, and regression analysis to evaluate predictors of caries reduction and salivary pH changes. A p-value < 0.05 was considered statistically significant. RESULTS: The intervention group showed a significant reduction in caries activity (p < 0.001) and a notable increase in salivary pH compared to the control group (p < 0.01). These results suggest that pomegranate consumption contributed to a marked improvement in oral health. Regression analysis indicated that pomegranate intake was a strong predictor of these positive outcomes, highlighting its potential as an effective natural supplement for improving oral health and reducing ECC. CONCLUSION: Pomegranate consumption proved to be an effective dietary intervention to reduce ECC and improve salivary pH. Long-term studies are needed for broader validation. HOW TO CITE THIS ARTICLE: Ramesh R, Syam S. Effectiveness of Pomegranate as a Dietary Intervention for Early Childhood Caries Prevention: A Randomized Control Trial. Int J Clin Pediatr Dent 2026;19(1):47-54. CI - Copyright (c) 2026; The Author(s). FAU - Ramesh, R AU - Ramesh R AUID- ORCID: 0000-0002-1957-3867 AD - Department of Pediatric and Preventive Dentistry, Saveetha Dental College, SIMATS Deemed University, Chennai, Tamil Nadu, India. FAU - Syam, Shilpa AU - Syam S AUID- ORCID: 0000-0001-6843-1382 AD - Department of Oral Medicine, Radiology and Special Care Dentistry, Saveetha Dental College, SIMATS Deemed University, Chennai, Tamil Nadu, India. LA - eng PT - Journal Article DEP - 20260115 PL - India TA - Int J Clin Pediatr Dent JT - International journal of clinical pediatric dentistry JID - 101585405 PMC - PMC12855020 OTO - NOTNLM OT - Decayed OT - Early childhood caries OT - Missing OT - Pomegranate OT - Salivary pH OT - and Filled Teeth index COIS- Source of support: Nil Conflict of interest: NoneConflict of interest: None EDAT- 2026/02/02 18:14 MHDA- 2026/02/02 18:15 PMCR- 2026/02/01 CRDT- 2026/02/02 06:44 PHST- 2025/04/01 00:00 [received] PHST- 2025/06/23 00:00 [accepted] PHST- 2026/02/02 18:15 [medline] PHST- 2026/02/02 18:14 [pubmed] PHST- 2026/02/02 06:44 [entrez] PHST- 2026/02/01 00:00 [pmc-release] AID - 10.5005/jp-journals-10005-3397 [doi] PST - ppublish SO - Int J Clin Pediatr Dent. 2026 Jan;19(1):47-54. doi: 10.5005/jp-journals-10005-3397. Epub 2026 Jan 15. PMID- 41624346 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260202 LR - 20260204 IS - 2624-9367 (Electronic) IS - 2624-9367 (Linking) VI - 7 DP - 2025 TI - The effects of traditional games on physical literacy among school-aged children. PG - 1759890 LID - 10.3389/fspor.2025.1759890 [doi] LID - 1759890 AB - INTRODUCTION: Physical literacy is crucial for promoting lifelong engagement in physical activity. In response to rising childhood inactivity, this study explores the impact of traditional children's games on physical literacy within a school context. METHODS: A quasi-experimental design was applied involving 60 students (aged 11-12) from two schools in Trabzon, Turkey. The experimental group participated in an 8-week program of culturally-rooted traditional games. The control group followed standard physical education activities. Pre- and post-test data were collected using a validated Physical Literacy Scale. RESULTS: Statistical analyses indicated significant improvements (p < .001) in all four domains of physical literacy-physical, psychological, social, and cognitive-in the experimental group compared to the control group. DISCUSSION: Traditional games are shown to be inclusive, culturally relevant, and effective pedagogical tools for improving physical literacy in school-aged children. Their integration into school curricula is supported as a cost-effective and holistic educational strategy. CI - (c) 2026 Cinar and Hassani. FAU - Cinar, Meliha AU - Cinar M AD - Department of Physical Education, Istanbul Gedik University, Istanbul, Turkiye. FAU - Hassani, Fahimeh AU - Hassani F AD - Department of Physical Education, Istanbul Gedik University, Istanbul, Turkiye. LA - eng PT - Journal Article DEP - 20260116 PL - Switzerland TA - Front Sports Act Living JT - Frontiers in sports and active living JID - 101765780 PMC - PMC12855449 OTO - NOTNLM OT - active lifestyles OT - culturally rooted play OT - movement skills OT - physical competence OT - physical literacy OT - traditonal game COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/02 13:09 MHDA- 2026/02/02 13:10 PMCR- 2026/01/16 CRDT- 2026/02/02 06:44 PHST- 2025/12/03 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/02/02 13:10 [medline] PHST- 2026/02/02 13:09 [pubmed] PHST- 2026/02/02 06:44 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - 10.3389/fspor.2025.1759890 [doi] PST - epublish SO - Front Sports Act Living. 2026 Jan 16;7:1759890. doi: 10.3389/fspor.2025.1759890. eCollection 2025. PMID- 41624184 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260202 LR - 20260926 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Development of a high-throughput UHPLC-MS/MS multi-method for the analysis of mycotoxins in plant-based milk alternatives as the basis for risk assessment. PG - 1709925 LID - 10.3389/fnut.2025.1709925 [doi] LID - 1709925 AB - Plant-based alternatives to animal-based foods represent a rapidly growing market, as more and more consumers are willing to include these products into their daily diets. One particular segment is plant-based milk alternatives (PBMAs). Environmental and ethical concerns mainly drive this growing trend. However, the raw materials used in the production of PBMAs are susceptible to mycotoxin contamination, and currently, there are no regulatory limits for mycotoxins in PBMAs. Therefore, analyzing PBMAs to get more information about the mycotoxin contamination in these products is of great interest. To obtain more exposure data, we developed a QuEChERS (quick, easy, cheap, effective, rugged, and safe)-based multi-mycotoxin method to analyze 31 Alternaria, Aspergillus, and Fusarium toxins in PBMAs using ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The method was successfully validated and applied to 100 different PBMAs from oats, rice, spelt, almonds, hazelnuts, walnuts, cashews, soy, peas, and hemp. Our results showed a frequent contribution of PBMAs to the overall mycotoxin exposure, and some of these products have to be considered critical for toddlers from a risk-assessment perspective. In particular, PBMAs made from oats, almonds, hazelnuts, and tiger nuts were assessed as a risk for this age group. CI - Copyright (c) 2026 Dick, Schuster, Schneidemann-Bostelmann, Asam and Rychlik. FAU - Dick, Fabian AU - Dick F AD - Chair of Analytical Food Chemistry, Technical University of Munich, Munich, Germany. FAU - Schuster, Maximilian AU - Schuster M AD - Chair of Analytical Food Chemistry, Technical University of Munich, Munich, Germany. FAU - Schneidemann-Bostelmann, Sarah AU - Schneidemann-Bostelmann S AD - Chair of Analytical Food Chemistry, Technical University of Munich, Munich, Germany. FAU - Asam, Stefan AU - Asam S AD - Chair of Analytical Food Chemistry, Technical University of Munich, Munich, Germany. FAU - Rychlik, Michael AU - Rychlik M AD - Chair of Analytical Food Chemistry, Technical University of Munich, Munich, Germany. LA - eng PT - Journal Article DEP - 20260115 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12853641 OTO - NOTNLM OT - Alternaria OT - Aspergillus OT - Fusarium OT - LC-MS/MS analysis OT - modified mycotoxins OT - multi-mycotoxin analysis OT - mycotoxins OT - plant-based milk alternatives COIS- MR is Chief Editor of Frontiers in Nutrition (section Food Chemistry). To avoid any conflict of interest, the editorial handling and peer-review process of this manuscript were conducted independently by another editor, and MR had no involvement in the editorial decision-making. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/02/02 18:13 MHDA- 2026/02/02 18:14 PMCR- 2026/01/15 CRDT- 2026/02/02 06:43 PHST- 2025/09/21 00:00 [received] PHST- 2025/11/30 00:00 [revised] PHST- 2025/12/01 00:00 [accepted] PHST- 2026/02/02 18:14 [medline] PHST- 2026/02/02 18:13 [pubmed] PHST- 2026/02/02 06:43 [entrez] PHST- 2026/01/15 00:00 [pmc-release] AID - 10.3389/fnut.2025.1709925 [doi] PST - epublish SO - Front Nutr. 2026 Jan 15;12:1709925. doi: 10.3389/fnut.2025.1709925. eCollection 2025. PMID- 41623719 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260202 LR - 20260204 IS - 2055-2076 (Print) IS - 2055-2076 (Electronic) IS - 2055-2076 (Linking) VI - 12 DP - 2026 Jan-Dec TI - Machine learning-based algorithms to identify factors associated with inadequate meal frequency among children aged 6-23 months in Somalia: Evidence from the Somalia Demographic and Health Survey 2020. PG - 20552076261415918 LID - 10.1177/20552076261415918 [doi] LID - 20552076261415918 AB - OBJECTIVES: Inadequate meal frequency (IMF) among children aged 6-23 months remains a pressing public health issue in Somalia, contributing to widespread malnutrition and hindering progress toward Sustainable Development Goals 2 (Zero Hunger) and 3 (Good Health and Well-being). This study investigates the most influential factors associated with IMF to inform targeted public health interventions. METHODS: Data from 4066 children were extracted from the 2020 Somalia Demographic and Health Survey, employing Five machine learning algorithms, Logistic Regression, Decision Tree, Random Forest, Support Vector Machine, and Gradient Boosting, and assessed for predictive performance using accuracy and area under the receiver operating characteristic curve (AUC-ROC) metrics. Feature importance was analyzed to identify key predictors of IMF. RESULTS: The prevalence of IMF was alarmingly high at 78.51%. The Gradient Boosting model outperformed other models with an accuracy of 89.55% and an AUC-ROC of 92.77%. Birth order emerged as the most dominant predictor across all models, accounting for 74.07% of the Gini importance in the Gradient Boosting model. Other significant predictors included child age, breastfeeding status, maternal education, household wealth, and region of residence. CONCLUSION: The high prevalence of IMF highlights an urgent need for targeted interventions. Strategies focusing on families with higher birth order children, maternal education, and poverty reduction may be crucial for improving child nutrition in Somalia. These findings demonstrate the potential of machine learning approaches in informing public health strategies and predictive screening in resource-limited settings. CI - (c) The Author(s) 2026. FAU - Omar, Mohamed Abdirahim AU - Omar MA AUID- ORCID: 0009-0003-5933-3846 AD - School of Postgraduate Studies and Research, Amoud University, Borama, Somalia. RINGGOLD: 472742 AD - Faculty of Health Sciences, Salaam University, Mogadishu, Somalia. FAU - Salih, Omran AU - Salih O AUID- ORCID: 0000-0002-7861-5502 AD - Institute of Systems Science, Durban University of Technology, Durban, South Africa. RINGGOLD: 472742 LA - eng PT - Journal Article DEP - 20260128 PL - United States TA - Digit Health JT - Digital health JID - 101690863 PMC - PMC12852601 OTO - NOTNLM OT - Machine learning OT - SDHS OT - Somalia OT - child nutrition OT - inadequate meal frequency OT - sustainable development COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/02/02 18:13 MHDA- 2026/02/02 18:14 PMCR- 2026/01/28 CRDT- 2026/02/02 06:38 PHST- 2025/07/25 00:00 [received] PHST- 2025/12/31 00:00 [accepted] PHST- 2026/02/02 18:14 [medline] PHST- 2026/02/02 18:13 [pubmed] PHST- 2026/02/02 06:38 [entrez] PHST- 2026/01/28 00:00 [pmc-release] AID - 10.1177_20552076261415918 [pii] AID - 10.1177/20552076261415918 [doi] PST - epublish SO - Digit Health. 2026 Jan 28;12:20552076261415918. doi: 10.1177/20552076261415918. eCollection 2026 Jan-Dec. PMID- 41623266 OWN - NLM STAT- In-Process LR - 20260413 IS - 1532-7914 (Electronic) IS - 0163-5581 (Linking) VI - 78 IP - 4-5 DP - 2026 TI - Methodological Considerations in "The Nutritional Impact of Childhood Cancer: Insights from a Feasibility Cohort Study". PG - 263-264 LID - 10.1080/01635581.2026.2623679 [doi] FAU - Vadhithala, Varshini AU - Vadhithala V AD - Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Deemed-to-be-University, Pune, India. FAU - Kumar, Arun AU - Kumar A AD - Faculty of Pharmaceutical Sciences, Graphic Era Hill University, Dehradun, India. AD - Centre for Promotion of Research, Graphic Era Deemed University, Dehradun, India. FAU - Verma, Sushma AU - Verma S AD - Department of Pharmaceutics, Noida Institute of Engineering & Technology (Pharmacy Institute), Greater Noida, India. FAU - Katkuri, Sushma Narsing AU - Katkuri SN AD - Department of Community Medicine, Malla Reddy Institute of Medical Sciences, Malla Reddy Vishwavidyapeeth, Hyderabad, India. LA - eng PT - Journal Article DEP - 20260202 PL - United States TA - Nutr Cancer JT - Nutrition and cancer JID - 7905040 SB - IM EDAT- 2026/02/02 13:08 MHDA- 2026/02/02 13:08 CRDT- 2026/02/02 06:33 PHST- 2026/02/02 13:08 [pubmed] PHST- 2026/02/02 13:08 [medline] PHST- 2026/02/02 06:33 [entrez] AID - 10.1080/01635581.2026.2623679 [doi] PST - ppublish SO - Nutr Cancer. 2026;78(4-5):263-264. doi: 10.1080/01635581.2026.2623679. Epub 2026 Feb 2. PMID- 41622837 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2026 Feb 2 TI - Large language model-assisted research question development in public health: a case study in the Special Supplemental Nutrition Program for Women, Infants, and Children. PG - e32 LID - 10.1017/S1368980026101876 [doi] LID - e32 AB - OBJECTIVE: To assess the feasibility of using large language models (LLM) to develop research questions about changes to the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) food packages. DESIGN: We conducted a controlled experiment using ChatGPT-4 and its plugin, MixerBox Scholarly, to generate research questions based on a section of the U.S. Department of Agriculture (USDA) summary of the final public comments on the WIC revision. Five questions weekly for 3 weeks were generated using LLM under two conditions: fed with or without relevant literature. The experiment generated ninety questions, which were evaluated using the Feasibility, Innovation, Novelty, Ethics and Relevance criteria. t tests and multivariate regression examined the difference by feeding status, artificial intelligence model, evaluator and criterion. SETTING: The United States. PARTICIPANTS: Six WIC expert evaluators from academia, government, industry and non-profit sectors. RESULTS: Five themes were identified: administrative barriers, nutrition outcomes, participant preferences, economics and other topics. Feeding and non-feeding groups had no significant differences (Coeff. = 0.03, P = 0.52). MixerBox-generated questions received significantly lower scores than ChatGPT (Coeff. = -0.11, P = 0.02). Ethics scores were significantly higher than feasibility scores (Coeff. = 0.65, P < 0.001). Significant differences were found between the evaluators (P < 0.001). CONCLUSIONS: The LLM applications can assist in developing research questions with acceptable qualities related to the WIC food package revisions. Future research is needed to compare the development of research questions between LLM and human researchers. FAU - Zhang, Qi AU - Zhang Q AUID- ORCID: 0000-0002-8513-1573 AD - Department of Health Behavior, Policy & Management, Joint School of Public Health, Macon & Joan Brock Virginia Health Sciences at Old Dominion Universityhttps://ror.org/04zjtrb98, Norfolk, VA, USA. FAU - Neupane, Bidusha AU - Neupane B AD - Department of Health Behavior, Policy & Management, Joint School of Public Health, Macon & Joan Brock Virginia Health Sciences at Old Dominion Universityhttps://ror.org/04zjtrb98, Norfolk, VA, USA. FAU - Patel, Priyanka AU - Patel P AD - Department of Health Behavior, Policy & Management, Joint School of Public Health, Macon & Joan Brock Virginia Health Sciences at Old Dominion Universityhttps://ror.org/04zjtrb98, Norfolk, VA, USA. FAU - Alkhalifah, Futun N AU - Alkhalifah FN AD - Department of Health Behavior, Policy & Management, Joint School of Public Health, Macon & Joan Brock Virginia Health Sciences at Old Dominion Universityhttps://ror.org/04zjtrb98, Norfolk, VA, USA. FAU - He, Yi AU - He Y AD - School of Computing, Data Sciences & Physics, William & Mary, Williamsburg, VA, USA. FAU - Hodges, Leslie AU - Hodges L AD - U.S. Department of Agriculture, Economic Research Service, Kansas City, MO, USA. LA - eng PT - Journal Article DEP - 20260202 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - *Large Language Models MH - *Food Assistance MH - Female MH - United States MH - *Public Health MH - Infant MH - Feasibility Studies MH - Generative Artificial Intelligence MH - Child PMC - PMC12917417 OTO - NOTNLM OT - Artificial intelligence OT - Infants, and Children OT - Large language model OT - Nutrition OT - Women COIS- There are no conflicts of interest. EDAT- 2026/02/02 06:28 MHDA- 2026/02/18 10:07 PMCR- 2026/02/02 CRDT- 2026/02/02 03:03 PHST- 2026/02/18 10:07 [medline] PHST- 2026/02/02 06:28 [pubmed] PHST- 2026/02/02 03:03 [entrez] PHST- 2026/02/02 00:00 [pmc-release] AID - S1368980026101876 [pii] AID - 10.1017/S1368980026101876 [doi] PST - epublish SO - Public Health Nutr. 2026 Feb 2;29(1):e32. doi: 10.1017/S1368980026101876. PMID- 41622733 OWN - NLM STAT- MEDLINE DCOM- 20260614 LR - 20260922 IS - 1550-9613 (Electronic) IS - 0278-4297 (Print) IS - 0278-4297 (Linking) VI - 45 IP - 7 DP - 2026 Jul TI - Evaluating the Need for Multiple Ultrasound Measurements for Accurate Prediction of Birthweight Using Estimated Fetal Weight. PG - 1433-1441 LID - 10.1002/jum.70180 [doi] AB - OBJECTIVES: To evaluate whether averaging replicate fetal biometry measurements during an examination improves estimated fetal weight (EFW) accuracy for predicting birthweight compared with a single set and to assess how variability in fetal biometric measurements changes across gestation. METHODS: Secondary analysis of the Eunice Kennedy Shriver National Institute of Child and Health and Human Development (NICHD) Fetal Growth Studies-Singletons. At each study visit, fetal head circumference (HC), abdominal circumference (AC), and femur length (FL) were measured in triplicate to compute EFW at each of 6 study visits (0-5). Variability among replicates was assessed across gestation using boxplots and two-way repeated measures ANOVA. For participants with visit 5 EFW (n = 1101), predictive accuracy of each individual measurement and their averages was compared with birthweight using average percent error and proportion within 10% of birthweight. One-way ANOVA and chi-square tests were applied. Sensitivity analyses included second-to-last visit, subgroups classified as small- or large-for-gestational age, and a subgroup of participants who delivered within 3 days of visit 5. RESULTS: Across visits, replicate HC, AC, and FL showed minimal variability, with no significant differences among replicates or across gestation. At visit 5, average EFW and standard deviations were similar across individual and averaged measurements. Percent errors ranged from 8.2 to 8.5% (p = .999), and proportion within 10% of birthweight ranged from 64.4 to 66.4% (p = .954). Sensitivity analyses produced similarly null findings. CONCLUSIONS: In a controlled research setting with credentialed sonographers and standardized protocols, averaging replicate fetal biometric measurements did not improve EFW prediction of birthweight. A single high-quality measurement of fetal biometry may be sufficient, although further research is warranted to confirm generalizability to routine clinical practice. CI - Published 2026. This article is a U.S. Government work and is in the public domain in the USA. FAU - St Ville, Madeleine E AU - St Ville ME AUID- ORCID: 0000-0002-9863-9720 AD - Biostatistics and Bioinformatics Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. FAU - Grantz, Katherine L AU - Grantz KL AUID- ORCID: 0000-0003-0276-8534 AD - Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes Health, Bethesda, Maryland, USA. FAU - Gleason, Jessica L AU - Gleason JL AD - Epidemiology Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes Health, Bethesda, Maryland, USA. FAU - Chen, Zhen AU - Chen Z AUID- ORCID: 0000-0002-9946-1362 AD - Biostatistics and Bioinformatics Branch, Division of Population Health Research, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, USA. LA - eng GR - HHSN27500006/NH/NIH HHS/United States GR - HHSN275200800003IC/NH/NIH HHS/United States GR - HHSN275200800013C/HD/NICHD NIH HHS/United States GR - HHSN275200800003I/HD/NICHD NIH HHS/United States GR - HHSN275200800002I/NH/NIH HHS/United States GR - HHSN275200800014C/NH/NIH HHS/United States GR - ZIA HD009013/ImNIH/Intramural NIH HHS/United States GR - HHSN275201000009C/NH/NIH HHS/United States GR - HHSN275200800003C/HD/NICHD NIH HHS/United States GR - HHSN275201000009C/HD/NICHD NIH HHS/United States GR - HHSN275200800002I/HD/NICHD NIH HHS/United States GR - HHSN275200800028C/HD/NICHD NIH HHS/United States GR - HHSN275200800002C/HD/NICHD NIH HHS/United States GR - HHSN275200800013C/NH/NIH HHS/United States GR - ZIA HD009014/ImNIH/Intramural NIH HHS/United States GR - HHSN275200800028C/NH/NIH HHS/United States GR - HHSN275200800012C/HD/NICHD NIH HHS/United States GR - HHSN275200800012C/NH/NIH HHS/United States PT - Journal Article DEP - 20260201 PL - England TA - J Ultrasound Med JT - Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine JID - 8211547 SB - IM MH - Humans MH - *Ultrasonography, Prenatal/methods MH - *Birth Weight/physiology MH - *Fetal Weight/physiology MH - Female MH - Reproducibility of Results MH - Pregnancy MH - Sensitivity and Specificity MH - Biometry/methods MH - Predictive Value of Tests MH - Infant, Newborn PMC - PMC13128283 MID - NIHMS2158799 OTO - NOTNLM OT - birthweight prediction OT - estimated fetal weight (EFW) OT - measurement error OT - replicate measurements OT - ultrasound biometry COIS- The authors declare no conflicts of interest. EDAT- 2026/02/02 06:27 MHDA- 2026/06/15 11:33 PMCR- 2026/04/30 CRDT- 2026/02/02 02:03 PHST- 2025/12/22 00:00 [revised] PHST- 2025/09/15 00:00 [received] PHST- 2026/01/10 00:00 [accepted] PHST- 2026/06/15 11:33 [medline] PHST- 2026/02/02 06:27 [pubmed] PHST- 2026/02/02 02:03 [entrez] PHST- 2026/04/30 00:00 [pmc-release] AID - 10.1002/jum.70180 [doi] PST - ppublish SO - J Ultrasound Med. 2026 Jul;45(7):1433-1441. doi: 10.1002/jum.70180. Epub 2026 Feb 1. PMID- 41621408 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260806 IS - 1873-5487 (Electronic) IS - 0188-4409 (Linking) VI - 57 IP - 4 DP - 2026 Jun TI - Multispecies Signatures and Driving Factors of Oral Microbiome Dysbiosis in Pediatric Crohn's Disease in the United Arab Emirates. PG - 103389 LID - S0188-4409(26)00012-3 [pii] LID - 10.1016/j.arcmed.2026.103389 [doi] AB - PURPOSE: Despite the recognized impact of the gut microbiome, research on the oral microbiome is limited, particularly in pediatric patients with Crohn's disease (CD). This study aims to explore salivary microbiome signatures in pediatric patients with CD from the United Arab Emirates (UAE), compared to healthy controls (HC), by analyzing early-life, lifestyle, and disease-specific factors driving dysbiosis. METHODS: Salivary samples from 52 pediatric patients with CD and HC (n = 26/group) were subjected to 16S rRNA sequencing using Oxford Nanopore technology. Bioinformatics and biostatistical analyses were employed to compare groups and identify microbiota signatures correlated with clinical data. RESULTS: Enrichment of several species, including Veillonella parvula, Veillonella dispar, and Prevotella denticola, with depletion of beneficial bacteria was observed in CD. Machine learning-based composite biomarker analysis identified 36 species distinguishing CD from HC, most of which are opportunistic pathogens, raising concerns about their potential impact on vulnerable pediatric patients with CD. Multifactorial analysis revealed significant oral microbiome dysbiosis in patients with CD across all 15 analyzed factors, with unique CD-specific biomarkers. The strongest associations with microbial alterations were demonstrated by disease duration, diet, exercise habits, early antibiotic exposure, and delivery method. Among the 19 species analyzed, Capnocytophaga gingivalis demonstrated multifactorial associations, emerging as an integrative biomarker of disease burden. The alpha-diversity was significantly lower in patients with CD, with distinctive beta-diversity patterns. CONCLUSION: This is the first comprehensive multifactorial analysis of the oral microbiome in pediatric patients with CD from the Middle East, employing novel machine learning approaches for composite biomarker discovery. Core dysbiotic species in CD may serve as potential diagnostic and prognostic biomarkers requiring validation in larger-scale studies. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Mesto, Ghaidaa AU - Mesto G AD - Department of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Al Atrash, Eman AU - Al Atrash E AD - Division of Pediatric Gastroenterology, Department of General Pediatrics, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates. FAU - Rawat, David AU - Rawat D AD - Queen Mary's University London, School of Medicine and Dentistry, London, UK. FAU - Elzayat, Hala AU - Elzayat H AD - Department of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. FAU - Miqdady, Mohamad AU - Miqdady M AD - Division of Pediatric Gastroenterology, Department of General Pediatrics, Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates. FAU - Al-Marzooq, Farah AU - Al-Marzooq F AD - Department of Medical Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates. Electronic address: f.almarzooq@uaeu.ac.ae. LA - eng PT - Journal Article DEP - 20260131 PL - United States TA - Arch Med Res JT - Archives of medical research JID - 9312706 RN - 0 (RNA, Ribosomal, 16S) RN - Pediatric Crohn's disease SB - IM MH - Humans MH - *Dysbiosis/microbiology MH - United Arab Emirates/epidemiology MH - *Crohn Disease/microbiology MH - Female MH - Child MH - RNA, Ribosomal, 16S/genetics MH - Male MH - Saliva/microbiology MH - *Microbiota/genetics MH - Adolescent MH - *Mouth/microbiology MH - Bacteria/genetics/classification/isolation & purification OTO - NOTNLM OT - Capnocytophaga gingivalis OT - Crohn's disease OT - Dysbiosis OT - Salivary microbiome OT - UAE OT - Veillonella EDAT- 2026/02/02 00:29 MHDA- 2026/06/12 13:03 CRDT- 2026/02/01 18:09 PHST- 2025/08/24 00:00 [received] PHST- 2025/11/30 00:00 [revised] PHST- 2026/01/21 00:00 [accepted] PHST- 2026/06/12 13:03 [medline] PHST- 2026/02/02 00:29 [pubmed] PHST- 2026/02/01 18:09 [entrez] AID - S0188-4409(26)00012-3 [pii] AID - 10.1016/j.arcmed.2026.103389 [doi] PST - ppublish SO - Arch Med Res. 2026 Jun;57(4):103389. doi: 10.1016/j.arcmed.2026.103389. Epub 2026 Jan 31. PMID- 41620790 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Jan 31 TI - The bidirectional dynamic relationship of teacher and peer support: a longitudinal analysis of student engagement in middle school physical education. LID - 10.1186/s40359-026-03960-5 [doi] LID - 285 AB - PURPOSE: This longitudinal study examined the reciprocal relationships among perceived teacher support, peer support, and student engagement in middle school physical education classes. METHODS: Using a two-wave panel design, data were collected from 477 Chinese middle school students at two time points: Wave 1 (Time 1, T1) in November 2022 and Wave 2 (Time 2, T1) in May 2023, with a six-month interval representing a typical academic semester. This temporal spacing allows for observing developmental changes while minimizing seasonal effects on physical activity patterns. Participants completed validated measures of teacher support, peer support, behavioral engagement, and emotional engagement. Data were analyzed via cross-lagged structural equation modeling to test bidirectional pathways while controlling for grade and gender. RESULTS: (1) Behavioral engagement at T1 positively predicted teacher support (beta = 0.22, p < 0.01) and peer support (beta = 0.19, p < 0.01) at T2. (2) Emotional engagement at T1 positively predicted teacher support (beta = 0.22, p < 0.01) and peer support (beta = 0.21, p < 0.01) at T2. (3) Peer support at T1 positively predicted emotional engagement (beta = 0.16, p < 0.01) and teacher support (beta = 0.14, p < 0.05 for behavioral model; beta = 0.17, p < 0.01 for emotional model) at T2. CONCLUSION: These findings reveal a spillover effect wherein student engagement fosters subsequent social support, and peer support reinforces both emotional engagement and teacher support. The study underscores the importance of pedagogical strategies that promote active learning and peer interaction, such as cooperative activities and student-centered tasks, to create mutually reinforcing cycles of engagement and support. CI - (c) 2026. The Author(s). FAU - Zhang, Ting AU - Zhang T AD - Physical Education College, Jiangxi Normal University, Nanchang, 330022, China. FAU - Han, Hongwei AU - Han H AD - School of Physical Education, Shanghai University of Sport, Shanghai, 200438, China. hanhongwei@sus.edu.cn. LA - eng PT - Journal Article DEP - 20260131 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - *Peer Group MH - Longitudinal Studies MH - *School Teachers/psychology MH - *Students/psychology MH - *Social Support MH - Female MH - *Physical Education and Training MH - Male MH - Child MH - Schools MH - Adolescent MH - China PMC - PMC12951929 OTO - NOTNLM OT - Middle school student OT - Peer support OT - Physical education OT - Student engagement OT - Teacher support COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethics Committee of College of Physical Education at Jiangxi Normal University. Written informed consent was obtained from all participants. The guidelines outlined in the Declaration of Helsinki were followed. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/01 00:44 MHDA- 2026/03/07 16:12 PMCR- 2026/01/31 CRDT- 2026/01/31 23:37 PHST- 2025/08/19 00:00 [received] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/03/07 16:12 [medline] PHST- 2026/02/01 00:44 [pubmed] PHST- 2026/01/31 23:37 [entrez] PHST- 2026/01/31 00:00 [pmc-release] AID - 10.1186/s40359-026-03960-5 [pii] AID - 3960 [pii] AID - 10.1186/s40359-026-03960-5 [doi] PST - epublish SO - BMC Psychol. 2026 Jan 31;14(1):285. doi: 10.1186/s40359-026-03960-5. PMID- 41620613 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1750-1172 (Electronic) IS - 1750-1172 (Linking) VI - 21 IP - 1 DP - 2026 Jan 31 TI - An exercise intervention in children and young adults with McArdle disease: feasibility, acceptability, and clinical outcomes. LID - 10.1186/s13023-026-04222-8 [doi] LID - 78 AB - INTRODUCTION: Patients with McArdle disease have reduced exercise capacity. Structured exercise programs in adults with McArdle disease can improve aerobic capacity and strength. However, structured exercise has not been evaluated in younger populations. Our aim was to determine the safety, feasibility, and acceptability of an exercise intervention in children and young adults with McArdle disease. METHODS: Children and young adults aged 5-30 years with McArdle disease were recruited through metabolic clinics in New South Wales, Australia, to complete a remote, supervised 12-week exercise intervention. Pre and/or post intervention, participants completed a treadmill cardiopulmonary exercise test (CPET), strength testing, habitual physical activity monitoring, a quality-of-life questionnaire, acceptability questionnaire, muscular Near Infrared Spectroscopy (NIRS), and blood samples. RESULTS: Five out of 10 eligible participants, with a median age of 17 years (range 13-29), were enrolled. Four met the feasibility target of 70% completed exercise sessions. Four episodes of mild rhabdomyolysis were reported during the study, but no participant required hospital admission. All participants reported they would participate in similar programs in the future. No significant changes were found in aerobic capacity, strength, habitual physical activity levels or quality of life. Trends were observed for lower perceived pain during CPET, and improved leg press. NIRS indicated a possible trend for improved muscle oxygen utilisation. CONCLUSION: A 12-week remotely delivered exercise intervention was found to be feasible, safe, and acceptable to children and young adults with McArdle disease. Although improvements to aerobic capacity and strength were not elicited, individual clinical benefits may have occurred. ONE SENTENCE TAKE HOME MESSAGE: An exercise intervention in children and young adults with McArdle disease is feasible, safe, and acceptable, and may elicit individual clinical benefits. FAU - Batten, Kiera AU - Batten K AUID- ORCID: 0000-0001-6257-397X AD - Department of Nutrition and Dietetics, The Children's Hospital at Westmead, Sydney, Australia. k.batten@unsw.edu.au. AD - Genetic Metabolic Disorders Service, The Children's Hospital at Westmead, Sydney, Australia. k.batten@unsw.edu.au. AD - Faculty of Medicine and Health, School of Health Sciences, UNSW, Sydney, Australia. k.batten@unsw.edu.au. FAU - Van Doorn, Nancy AU - Van Doorn N AUID- ORCID: 0000-0002-2380-8278 AD - Faculty of Medicine and Health, School of Health Sciences, UNSW, Sydney, Australia. AD - Children's Hospital Institute of Sports Medicine, The Children's Hospital at Westmead, Sydney, Australia. FAU - McManus, Christopher AU - McManus C AUID- ORCID: 0000-0003-3871-3842 AD - University of Essex, School of Sport, Rehabilitation and Exercise Sciences, Colchester, UK. FAU - Jones, Ben AU - Jones B AUID- ORCID: 0000-0002-5385-4144 AD - University of Essex, School of Sport, Rehabilitation and Exercise Sciences, Colchester, UK. FAU - Simar, David AU - Simar D AUID- ORCID: 0000-0002-3862-1932 AD - Faculty of Medicine and Health, School of Health Sciences, UNSW, Sydney, Australia. FAU - Broderick, Carolyn AU - Broderick C AUID- ORCID: 0000-0003-0096-796X AD - Faculty of Medicine and Health, School of Health Sciences, UNSW, Sydney, Australia. AD - Children's Hospital Institute of Sports Medicine, The Children's Hospital at Westmead, Sydney, Australia. FAU - Bhattacharya, Kaustuv AU - Bhattacharya K AUID- ORCID: 0000-0003-0518-5879 AD - Genetic Metabolic Disorders Service, The Children's Hospital at Westmead, Sydney, Australia. AD - Faculty of Medicine and Health, School of Clinical Medicine, UNSW, Sydney, Australia. LA - eng PT - Journal Article DEP - 20260131 PL - England TA - Orphanet J Rare Dis JT - Orphanet journal of rare diseases JID - 101266602 SB - IM MH - Humans MH - Adolescent MH - *Glycogen Storage Disease Type V/therapy/physiopathology MH - Adult MH - Child MH - Female MH - Young Adult MH - Male MH - *Exercise Therapy/methods MH - Quality of Life MH - Child, Preschool MH - Exercise/physiology MH - Feasibility Studies MH - Exercise Test PMC - PMC12947363 OTO - NOTNLM OT - CPET OT - GSD V OT - NIRs OT - Paediatric OT - Remote OT - Safety COIS- Declarations. Ethical approval: Ethics approval was granted by the Sydney Children's Hospital Network Human Research Ethics Committee (2023/ETH01965). Patient consent: Patient and/or guardian written consent was obtained from all participants prior to enrolment into the study. Competing interests: The authors declare that they have no competing interests. EDAT- 2026/02/01 00:44 MHDA- 2026/06/27 06:43 PMCR- 2026/01/31 CRDT- 2026/01/31 23:23 PHST- 2025/09/18 00:00 [received] PHST- 2026/01/16 00:00 [accepted] PHST- 2026/06/27 06:43 [medline] PHST- 2026/02/01 00:44 [pubmed] PHST- 2026/01/31 23:23 [entrez] PHST- 2026/01/31 00:00 [pmc-release] AID - 10.1186/s13023-026-04222-8 [pii] AID - 4222 [pii] AID - 10.1186/s13023-026-04222-8 [doi] PST - epublish SO - Orphanet J Rare Dis. 2026 Jan 31;21(1):78. doi: 10.1186/s13023-026-04222-8. PMID- 41620589 OWN - NLM STAT- In-Process LR - 20260813 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jan 31 TI - Adherence to the EAT-Lancet planetary health diet and its associations with obesity and health-related quality of life in Iranian adolescents: a cross-sectional study. LID - 10.1186/s12889-025-26174-7 [doi] LID - 746 AB - BACKGROUND: Adolescent obesity and diminished health-related quality of life (HRQoL) remain critical global issues and are further complicated by the urgent need for sustainable diets amid climate change. The Planetary Health Diet Index (PHDI), which is based on EAT-Lancet recommendations, connects human nutrition with environmental sustainability. METHODS: This cross-sectional study of 1,038 students (mean age, 15.13 +/- 1.53 years) from the 2024-2025 academic year assessed dietary intake via a validated 147-item food frequency questionnaire. Anthropometrics followed standard protocols, and HRQoL was evaluated with the Pediatric Quality of Life Inventory Version 4.0 Generic Core Scales (PedsQL). Adjusted binary logistic regression models, controlling for age, sex, ethnicity, socioeconomic status, sleep duration, screen time, and energy intake, were used to analyze associations (SPSS version 28). RESULTS: The mean PHDI score was 50.79 (95% CI, 50.13-51.45; range, 19.66-94.46). According to the adjusted analyses, the highest quartile was associated with lower odds of general obesity (OR, 0.44; 95% CI, 0.24-0.81), abdominal obesity (OR, 0.56; 95% CI, 0.36-0.89), and impaired HRQoL (OR, 0.41; 95% CI, 0.24-0.70; all P < 0.05). CONCLUSION: Greater PHDI adherence is associated with improved anthropometric status and HRQoL in adolescents, underscoring the potential of sustainable diets for holistic health promotion. Longitudinal studies are needed to establish causality and generalizability. CI - (c) 2026. The Author(s). FAU - Derakhshandeh, Soroor AU - Derakhshandeh S AD - Department of Nutritional Sciences, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Namkhah, Zahra AU - Namkhah Z AD - Department of Nutritional Sciences, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. FAU - Mohebi, Sina AU - Mohebi S AD - Food, Health and Environment (FH&E), MSc Program, University of Eastern Piedmont "Amedeo Avogadro", Vercelli, Italy. FAU - Sobhani, Seyyed Reza AU - Sobhani SR AUID- ORCID: 0000-0002-7308-8504 AD - Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. SeyyedRezaSobhani@gmail.com.com. FAU - Dehnavi, Zahra AU - Dehnavi Z AUID- ORCID: 0000-0003-4926-4229 AD - Department of Nutritional Sciences, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran. dehnaviz941@gmail.com. LA - eng GR - 4022488/Mashhad University of Medical Sciences/ PT - Journal Article DEP - 20260131 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM PMC - PMC12933899 OTO - NOTNLM OT - Adolescents OT - Dietary index OT - Health-related quality of life OT - Sustainable diet COIS- Declarations. Ethics approval and consent to participate: The Research Ethics Committee of Mashhad University of Medical Sciences, Mashhad, Iran, approved the study protocol (approval number IR.MUMS.MEDICAL.REC.1403.211). All procedures were performed in accordance with the ethical standards set forth in the 1964 Helsinki Declaration and its subsequent amendments. Parents and legal guardians of adolescents participating in this study were asked for passive informed consent and adolescents themselves were asked for active informed consent before the start of the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/02/01 00:44 MHDA- 2026/02/01 00:44 PMCR- 2026/01/31 CRDT- 2026/01/31 23:23 PHST- 2025/10/29 00:00 [received] PHST- 2025/12/31 00:00 [accepted] PHST- 2026/02/01 00:44 [pubmed] PHST- 2026/02/01 00:44 [medline] PHST- 2026/01/31 23:23 [entrez] PHST- 2026/01/31 00:00 [pmc-release] AID - 10.1186/s12889-025-26174-7 [pii] AID - 26174 [pii] AID - 10.1186/s12889-025-26174-7 [doi] PST - epublish SO - BMC Public Health. 2026 Jan 31;26(1):746. doi: 10.1186/s12889-025-26174-7. PMID- 41620553 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20261010 IS - 1432-198X (Electronic) IS - 0931-041X (Linking) VI - 41 IP - 7 DP - 2026 Jul TI - Efficacy of the STARZ stratification score in determining the risk of acute kidney injury in critically ill neonates. PG - 2193-2203 LID - 10.1007/s00467-026-07152-6 [doi] AB - BACKGROUND: Neonatal acute kidney injury (AKI) is a frequent and severe complication in critically ill newborns. The STARZ score was originally developed and validated in the Indian population to stratify AKI risk during the first week of hospitalization, with limited validation in other settings. This study aimed to evaluate its predictive performance for AKI and mortality at two timepoints during early Neonatal Intensive Care Unit (NICU) hospitalization and to validate it in our setting. METHODS: A prospective cohort study was conducted in the NICU of Guillermo Grant Benavente Hospital, Chile, between August 2023 and April 2024. Neonates >/= 25 weeks gestational age and >/= 500 g birth weight were included. The STARZ score was calculated at 12 and 48-72 h post-admission. The analyses included logistic regression, ROC curves, and reliability testing. RESULTS: Of 113 neonates, 19 (16.8%) developed AKI. AKI was significantly associated with gestational age < 29 weeks and birth weight < 1000 g. The STARZ score demonstrated modest discriminatory capacity for AKI, with an AUC of 0.66 at 12 h and 0.72 at 48-72 h, with no significant differences observed between time points. For mortality, the score yielded an AUC of 0.91. CONCLUSIONS: The STARZ score showed lower predictive performance for AKI than in the original reports, while its association with mortality should be interpreted cautiously, as it may reflect AKI severity. These findings highlight the need to validate and adapt clinical risk scores across settings and develop future tools incorporating early and sensitive biomarkers for improved risk stratification. CI - (c) 2026. The Author(s), under exclusive licence to International Pediatric Nephrology Association. FAU - Bascur Postel, Maria Nicole AU - Bascur Postel MN AUID- ORCID: 0009-0000-2524-2645 AD - Departamento de Pediatria, Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile. mbascur@udec.cl. AD - Servicio de Pediatria, Hospital Guillermo Grant Benavente, Concepcion, Chile. mbascur@udec.cl. FAU - Bancalari, Aldo AU - Bancalari A AD - Departamento de Pediatria, Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile. FAU - Rodriguez-Nunez, Ivan AU - Rodriguez-Nunez I AD - Laboratorio de Fisiologia del Movimiento, Departamento de Kinesiologia, Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile. FAU - Palma, Valentina AU - Palma V AD - Departamento de Pediatria, Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile. FAU - Nicolas, Prisila AU - Nicolas P AD - Departamento de Pediatria, Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile. FAU - Mayorga, Gonzalo AU - Mayorga G AD - Servicio de Pediatria, Hospital Guillermo Grant Benavente, Concepcion, Chile. FAU - Irribarra, Gloria AU - Irribarra G AD - Servicio de Pediatria, Hospital Guillermo Grant Benavente, Concepcion, Chile. FAU - Sandoval, Macarena AU - Sandoval M AD - Departamento de Pediatria, Facultad de Medicina, Universidad de Concepcion, Concepcion, Chile. LA - eng PT - Journal Article DEP - 20260201 PL - Germany TA - Pediatr Nephrol JT - Pediatric nephrology (Berlin, Germany) JID - 8708728 SB - IM MH - Humans MH - *Acute Kidney Injury/diagnosis/mortality/etiology/epidemiology MH - Infant, Newborn MH - Critical Illness MH - Prospective Studies MH - Risk Assessment/methods MH - Chile/epidemiology MH - Female MH - Male MH - Intensive Care Units, Neonatal/statistics & numerical data MH - Gestational Age MH - Reproducibility of Results MH - Risk Factors MH - ROC Curve MH - Birth Weight MH - Predictive Value of Tests MH - Severity of Illness Index OTO - NOTNLM OT - Acute kidney injury OT - Mortality OT - Neonatal OT - STARZ score COIS- Declarations. Ethics approval and consent to participate: This research was conducted in accordance with the principles of the Declaration of Helsinki and was approved by the Ethical Scientific Committee of the Servicio de Salud Concepcion, Chile (Approval Resolution No. 6412, issued on July 21, 2023.). Written informed consent was obtained from the parents of all neonates who met the inclusion criteria. Competing interests: The authors declare no competing interests. EDAT- 2026/02/01 00:44 MHDA- 2026/05/22 12:34 CRDT- 2026/01/31 23:17 PHST- 2025/07/16 00:00 [received] PHST- 2026/01/06 00:00 [accepted] PHST- 2025/12/08 00:00 [revised] PHST- 2026/05/22 12:34 [medline] PHST- 2026/02/01 00:44 [pubmed] PHST- 2026/01/31 23:17 [entrez] AID - 10.1007/s00467-026-07152-6 [pii] AID - 10.1007/s00467-026-07152-6 [doi] PST - ppublish SO - Pediatr Nephrol. 2026 Jul;41(7):2193-2203. doi: 10.1007/s00467-026-07152-6. Epub 2026 Feb 1. PMID- 41619773 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 2049-4408 (Electronic) IS - 2049-4394 (Linking) VI - 108-B IP - 2 DP - 2026 Feb 1 TI - Psychometric evaluation of Patient-Reported Outcome Measurement Information System (PROMIS) measures in children and adolescents with lower limb orthopaedic conditions : construct validity, reliability, and responsiveness. PG - 259-266 LID - 10.1302/0301-620X.108B2.BJJ-2025-0277.R1 [doi] AB - AIMS: The Patient-Reported Outcomes Measurement Information System (PROMIS) has not been broadly validated for use in paediatric patients with lower limb musculoskeletal conditions. The aim of this study was to evaluate the psychometric properties of PROMIS administered using computerized adaptive testing. METHODS: This was a single-centre prospective study involving consecutive patients, aged between 11 and 17 years, with orthopaedic conditions affecting the lower limbs. The convergent and divergent construct validity of PROMIS domains with corresponding subscales of the Paediatric Outcomes Data Collection Instrument (PODCI) were assessed in Group A. The reliability was assessed by retesting a sub-group (Group B) of patients from Group A with the same PROMIS domains in those whose condition was not expected to vary within a month of their initial assessment. PROMIS domain responses preoperatively, and > six months postoperatively, were assessed in Group C. RESULTS: The construct validity was assessed in 280 patients in Group A, and convergent validity was achieved between the PROMIS and PODCI Mobility domains (r = 0.73; p < 0.001), Upper Extremity domains (r = 0.52; p < 0.001), PROMIS Physical Activity domain and PODCI Sports and Physical Function subscale (r = 0.57; p < 0.001), PROMIS Depressive Symptoms domain and PODCI Happiness subscale (r = -0.54; p < 0.001), and PROMIS Pain domain and PODCI Pain/Comfort subscale (r = -0.71; p < 0.001). Divergent validity criteria were met with a correlation of < 0.30. The median number of questions required to answer on PROMIS was less than on PODCI. Reliability was assessed in 51 patients in Group B, in whom the PROMIS domains were collected again following a mean of 20 days. Test-retest reliability was highest for Mobility (intraclass correlation coefficient (ICC) = 0.84), Depressive Symptoms (ICC = 0.75), and Pain (ICC = 0.74). Responsiveness was assessed in 150 patients in Group C in whom PROMIS domains were collected preoperatively and at a mean of ten months postoperatively. The largest effect sizes were seen in the Pain and Mobility domains, with smaller improvements in the Physical Activity, Depressive Symptoms, and Upper Extremity domains. CONCLUSION: PROMIS domains of Mobility, Physical Activity, Depressive Symptoms, and Pain may be useful for assessing patient-reported health status in paediatric patients with lower limb orthopaedic conditions. CI - (c) 2026 The British Editorial Society of Bone & Joint Surgery. FAU - Nguyen, Hillary Brenda AU - Nguyen HB AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Miller, Patricia E AU - Miller PE AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Sullivan, Nicholas AU - Sullivan N AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Mahan, Susan T AU - Mahan ST AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Spencer, Samantha A AU - Spencer SA AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Kasser, James R AU - Kasser JR AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Milewski, Matthew AU - Milewski M AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Kramer, Dennis AU - Kramer D AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - May, Collin J AU - May CJ AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Department of Orthopaedic Surgery, Boston Children's Hospital, Boston, Massachusetts, USA. LA - eng PT - Journal Article PT - Validation Study DEP - 20260201 PL - England TA - Bone Joint J JT - The bone & joint journal JID - 101599229 SB - IM MH - Humans MH - Child MH - Adolescent MH - *Patient Reported Outcome Measures MH - Psychometrics MH - Female MH - Male MH - Reproducibility of Results MH - Prospective Studies MH - *Lower Extremity/surgery MH - *Musculoskeletal Diseases/surgery/psychology MH - Surveys and Questionnaires COIS- D. Kramer reports education support payments from Arthrex/Kairos Surgical and Smith & Nephew, unrelated to this study. S. A. Spencer is on the Medical Advisory Board for Little People of America and the Advisory Board of Project FAVA, and is a Board Member of the Massachusetts Orthopaedic Association, Clerk for the Children's Orthopaedic Surgery Foundation, Immediate Past President of the Michigan Medical Alumni Society, and Massachusetts Councilor for the American Academy of Orthopaedic Surgeons. EDAT- 2026/02/01 00:43 MHDA- 2026/02/01 00:44 CRDT- 2026/01/31 19:03 PHST- 2026/02/01 00:44 [medline] PHST- 2026/02/01 00:43 [pubmed] PHST- 2026/01/31 19:03 [entrez] AID - BJJ-2025-0277.R1 [pii] AID - 10.1302/0301-620X.108B2.BJJ-2025-0277.R1 [doi] PST - epublish SO - Bone Joint J. 2026 Feb 1;108-B(2):259-266. doi: 10.1302/0301-620X.108B2.BJJ-2025-0277.R1. PMID- 41619084 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260818 IS - 1573-7365 (Electronic) IS - 0885-7490 (Print) IS - 0885-7490 (Linking) VI - 41 IP - 1 DP - 2026 Jan 31 TI - Opioid peptides in autism spectrum disorder and gluten-free casein-free diet as a therapeutic approach. PG - 24 LID - 10.1007/s11011-026-01789-w [doi] LID - 24 AB - According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, Autism Spectrum Disorder (ASD) is characterized by persistent difficulties in social communication and interaction, together with restricted and repetitive behaviors, interests, or activities. The diagnosis of ASD currently relies on comprehensive assessments of developmental history and behavioral patterns, as there are no validated laboratory tests for a definitive clinical diagnosis. While evidence-based interventions are largely restricted to educational and behavioral programs, many individuals with ASD and their caregivers explore complementary approaches, including dietary interventions. Among these, the gluten-free, casein-free (GFCF) diet is one of the most frequently adopted strategies. A leading hypothesis posits that those increased concentrations of opioid peptides such as gluteomorphin and caseomorphin derived from the incomplete digestion of gluten and casein may contribute to the severity of ASD symptoms. It is further suggested that eliminating these dietary proteins could reduce opioid peptide concentrations in biofluids and improve clinical outcomes. The present systematic review was created by reviewers who searched PubMed, Web of Science, and Scopus databases, covering the period from January 1980 to March 2025. The search strategy combined standardized keywords and Medical Subject Headings terms. The search strategy included a combination of keywords commonly used in the literature to represent ASD, opioid peptides, and GFCF diets. A systematic literature search was carried out on PubMed and Web of Science and a total of 17 articles were included. Although preliminary findings from clinical and laboratory studies are promising, conclusive evidence regarding the efficacy of the GFCF diet remains lacking. This review aims to synthesize current findings on the relationship between opioid peptides and ASD, with a particular focus on the neurological effects of food-derived peptides and their potential role in therapeutic dietary interventions. CI - (c) 2026. The Author(s). FAU - Ozturk, Elif AU - Ozturk E AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Karadeniz Technical University, Farabi Street No:88, Trabzon, Turkey. elifyayli@ktu.edu.tr. FAU - Aslan Ci̇n, Nazli Nur AU - Aslan Ci̇n NN AUID- ORCID: 0000-0002-4458-8817 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Karadeniz Technical University, Farabi Street No:88, Trabzon, Turkey. FAU - Cansu, Ali AU - Cansu A AUID- ORCID: 0000-0002-1930-6312 AD - Faculty of Medicine, Department of Pediatric Diseases, Karadeniz Technical University, Trabzon, Turkey. FAU - Akyol, Asli AU - Akyol A AUID- ORCID: 0000-0001-6301-6358 AD - Faculty of Health Sciences, Department of Nutrition and Dietetics, Hacettepe University, Ankara, Turkey. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260131 PL - United States TA - Metab Brain Dis JT - Metabolic brain disease JID - 8610370 RN - 0 (Caseins) RN - 0 (Opioid Peptides) SB - IM MH - Humans MH - *Autism Spectrum Disorder/diet therapy/metabolism MH - *Diet, Gluten-Free/methods MH - *Caseins MH - *Opioid Peptides/metabolism MH - Animals PMC - PMC12860830 OTO - NOTNLM OT - Autism spectrum disorder OT - Caseomorphin OT - Child health OT - Gluten-free casein-free diet OT - Gluteomorphin COIS- Declarations. Ethical approval: Not required. Consent to publish: Not applicable. Consent to participate: Not applicable. Systematic review registration: PROSPERO CRD420251207178. Competing interests: The authors declare no competing interests. EDAT- 2026/01/31 12:35 MHDA- 2026/01/31 12:36 PMCR- 2026/01/31 CRDT- 2026/01/31 11:16 PHST- 2025/07/06 00:00 [received] PHST- 2026/01/14 00:00 [accepted] PHST- 2026/01/31 12:36 [medline] PHST- 2026/01/31 12:35 [pubmed] PHST- 2026/01/31 11:16 [entrez] PHST- 2026/01/31 00:00 [pmc-release] AID - 10.1007/s11011-026-01789-w [pii] AID - 1789 [pii] AID - 10.1007/s11011-026-01789-w [doi] PST - epublish SO - Metab Brain Dis. 2026 Jan 31;41(1):24. doi: 10.1007/s11011-026-01789-w. PMID- 41618611 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260706 IS - 1879-3479 (Electronic) IS - 0020-7292 (Linking) VI - 173 IP - 1 DP - 2026 Apr TI - Osteopontin levels in maternal serum and placenta: Associations with fetal growth restriction and neonatal outcomes. PG - 514-520 LID - 10.1002/ijgo.70844 [doi] AB - OBJECTIVE: To investigate maternal serum and placental osteopontin levels in pregnancies complicated with fetal growth restriction (FGR) and to evaluate their association with composite adverse neonatal outcomes (CANO). METHODS: A prospective case-control study was conducted at Etlik City Hospital between March and September 2024, including 40 women with pregnancies affected by FGR (34-39 weeks) and 40 gestational age-matched healthy control women. FGR was diagnosed using Delphi criteria. Maternal venous blood and placental samples were collected at delivery. Serum and placental osteopontin levels were measured using enzyme-linked immunosorbent assay. Placental osteopontin concentrations were normalized to total protein by the Bradford method (ng/mg protein). Statistical analyses included Mann-Whitney U, chi(2), and Fisher exact tests, and receiver operating characteristic (ROC) analysis. RESULTS: A total of 80 participants were analyzed. Gravidity and parity were lower in the FGR group, whereas maternal age and body mass index were comparable. As expected, adverse perinatal outcomes were more frequent in the FGR group. Both maternal serum and placental osteopontin levels were significantly decreased in FGR cases compared with controls (P = 0.002 and P < 0.001, respectively). ROC analysis demonstrated the best predictive performance for placental osteopontin normalized to total protein, with a cut-off of 61.2 ng/mg (area under the curve [AUC] 0.791, sensitivity 77.5%, specificity 70.0%). Lower osteopontin levels were also predictive of CANO (AUC up to 0.760, P < 0.001). CONCLUSIONS: In pregnancies complicated by FGR, osteopontin levels were significantly reduced in both maternal serum and placental tissue. This decrease may reflect impaired spiral artery remodeling and placental angiogenesis, contributing to the molecular mechanisms of placental insufficiency and adverse neonatal outcomes. CI - (c) 2026 International Federation of Gynecology and Obstetrics. FAU - Ayas Ozkan, Merve AU - Ayas Ozkan M AUID- ORCID: 0000-0002-2437-9719 AD - Department of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Vanli Tonyali, Nazan AU - Vanli Tonyali N AUID- ORCID: 0000-0002-7284-6887 AD - Department of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Dayanan, Ruken AU - Dayanan R AUID- ORCID: 0000-0002-8192-8841 AD - Department of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Duygulu Bulan, Dilara AU - Duygulu Bulan D AUID- ORCID: 0000-0001-9983-2306 AD - Department of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Cetin, Sevinc AU - Cetin S AUID- ORCID: 0009-0004-0547-1888 AD - Department of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Beydilli Sural, Eda AU - Beydilli Sural E AUID- ORCID: 0009-0003-6893-1282 AD - Department of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Uner, Halit AU - Uner H AUID- ORCID: 0000-0002-5388-4183 AD - Department of Pathology, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Celen, Sevki AU - Celen S AUID- ORCID: 0000-0001-7033-3474 AD - Department of Perinatology, Ankara Etlik City Hospital, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260130 PL - United States TA - Int J Gynaecol Obstet JT - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JID - 0210174 RN - 106441-73-0 (Osteopontin) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Osteopontin/blood/analysis/metabolism MH - *Fetal Growth Retardation/blood MH - Case-Control Studies MH - *Placenta/metabolism/chemistry MH - Adult MH - Prospective Studies MH - Pregnancy Outcome MH - Infant, Newborn MH - ROC Curve MH - Gestational Age MH - Biomarkers/blood OTO - NOTNLM OT - fetal growth retardation OT - osteopontin OT - placenta OT - pregnancy outcome EDAT- 2026/01/31 06:31 MHDA- 2026/03/14 06:33 CRDT- 2026/01/31 02:13 PHST- 2025/12/13 00:00 [revised] PHST- 2025/09/26 00:00 [received] PHST- 2026/01/19 00:00 [accepted] PHST- 2026/03/14 06:33 [medline] PHST- 2026/01/31 06:31 [pubmed] PHST- 2026/01/31 02:13 [entrez] AID - 10.1002/ijgo.70844 [doi] PST - ppublish SO - Int J Gynaecol Obstet. 2026 Apr;173(1):514-520. doi: 10.1002/ijgo.70844. Epub 2026 Jan 30. PMID- 41617805 OWN - NLM STAT- MEDLINE DCOM- 20260706 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jan 30 TI - Three dimensional palatal morphology and dentoalveolar differences after extraction and non extraction treatment in class II malocclusion. PG - 6728 LID - 10.1038/s41598-026-37842-y [doi] LID - 6728 AB - Digital technologies have transformed orthodontics by enabling precise three-dimensional (3D) assessment of treatment outcomes; however, the effects of extraction versus non-extraction strategies on palatal morphology in Class II malocclusions remain underexplored. This study quantified segmental palatal volume and surface changes, along with skeletal-dentoalveolar outcomes, using digital model analysis integrated with cephalometrics. Records of 69 post-pubertal patients treated with fixed appliances (Class II, n = 34; Class I controls, n = 35) were retrospectively analyzed, each subdivided into extraction and non-extraction protocols. Maxillary casts were scanned with Sirona inEos X5 and segmented in Materialise 3-Matic to compute palatal volume and surface area, while cephalometric variables were derived from lateral radiographs (Dolphin Imaging). Group comparisons were performed using non-parametric tests (p < 0.05). Multivariable regression analyses were conducted to identify dentoalveolar predictors of palatal remodeling. Intra-examiner repeatability was excellent, as indicated by a high intraclass correlation coefficient (ICC >/= 0.90). Skeletal changes were minimal and comparable across groups. Dentoalveolar findings demonstrated significant maxillary incisor protrusion in non-extraction protocols and retrusion in extraction protocols (p < 0.05). Anterior palatal volume and surface area increased across all groups. Overall, measurable differences in total palatal volume and surface area were observed between extraction and non-extraction treatment strategies. Regression analyses indicated that sagittal dentoalveolar displacement was associated with palatal remodeling, whereas angular and vertical dental variables showed limited independent influence. Extraction and non-extraction treatment protocols were associated with measurable differences in three-dimensional palatal volume and surface area, reflecting distinct dentoalveolar and palatal remodeling patterns between treatment strategies. CI - (c) 2026. The Author(s). FAU - Rubendiz, Meliha AU - Rubendiz M AD - Department of Orthodontics, Faculty of Dentistry, Ankara University, 06500, Ankara, Turkey. FAU - Altunal, Ezgi Kardelen AU - Altunal EK AD - Department of Orthodontics, The Graduate School of Health Sciences of Ankara University, 06110, Ankara, Turkey. FAU - Kadioglu, Merve Berika AU - Kadioglu MB AD - Department of Orthodontics, Faculty of Dentistry, Ankara University, 06500, Ankara, Turkey. mkadioglu@ankara.edu.tr. FAU - Durmaz, Meyra AU - Durmaz M AD - Department of Orthodontics, Faculty of Dentistry, Ankara University, 06500, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20260130 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Malocclusion, Angle Class II/therapy/diagnostic imaging/pathology/surgery MH - *Tooth Extraction MH - *Imaging, Three-Dimensional MH - Cephalometry MH - *Palate/diagnostic imaging/pathology/anatomy & histology MH - Female MH - Male MH - Child MH - Retrospective Studies MH - Adolescent PMC - PMC12913599 OTO - NOTNLM OT - 3D digital models OT - Cephalometric analysis OT - Class II malocclusion OT - Digital orthodontics OT - Extraction vs non-extraction OT - Palatal morphology OT - Palatal volume and surface area COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: The study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of the Faculty of Dentistry, Ankara University (Approval No: 36290600/58/2021; Approval Date: 15.09.2021)." Informed consent: Written informed consent for the academic use of medical records was obtained from all participants at the beginning of treatment as part of routine clinical procedures. No additional consent was required for this retrospective analysis. All the data were anonymized prior to analysis. EDAT- 2026/01/31 00:29 MHDA- 2026/02/18 00:49 PMCR- 2026/01/30 CRDT- 2026/01/30 23:23 PHST- 2025/10/15 00:00 [received] PHST- 2026/01/27 00:00 [accepted] PHST- 2026/02/18 00:49 [medline] PHST- 2026/01/31 00:29 [pubmed] PHST- 2026/01/30 23:23 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - 10.1038/s41598-026-37842-y [pii] AID - 37842 [pii] AID - 10.1038/s41598-026-37842-y [doi] PST - epublish SO - Sci Rep. 2026 Jan 30;16(1):6728. doi: 10.1038/s41598-026-37842-y. PMID- 41617778 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261019 IS - 1530-0447 (Electronic) IS - 0031-3998 (Print) IS - 0031-3998 (Linking) VI - 100 IP - 3 DP - 2026 Aug TI - Predicting off-track development in infants aged 0-6 months in low-resource settings using machine learning. PG - 1100-1108 LID - 10.1038/s41390-026-04761-7 [doi] AB - BACKGROUND: This study aimed to address the critical gap in the limited application of machine learning (ML) for identifying developmental delays in low-resource settings by developing models to predict off-track development in infants aged 0 to 6 months and identify key predictors. METHODS: A cross-sectional study involving 1,995 singleton infants aged 0 to 6 months was conducted in Kaloleni and Rabai sub-counties, Kilifi, Kenya, between March 2023 and March 2024. Development was assessed using the World Health Organization's Indicators of Infant and Young Child Development tool, with Development-for-Age Z-scores used to classify infants as on- or off-track. Ridge logistic regression (LR), random forest (RF), and extreme gradient boosting (XGBoost) models were trained using sociodemographic, psychosocial, clinical/biological, nutritional, and health-related predictors. Performance was evaluated using area under the receiver operating characteristic curve (AUC), accuracy, sensitivity, and specificity. SHapley Additive exPlanations enhanced model interpretability. RESULTS: Approximately 10.4% of infants were developmentally off-track. Ridge LR, RF, and XGBoost showed similar performance, with AUCs of 76.6%, 75.8%, and 76.1%, respectively. Limited psychosocial stimulation and increasing infant age were the strongest predictors. CONCLUSIONS: This study highlights the burden of developmental delays in low-resource settings. ML models show promise for early risk prediction and targeted intervention, though further validation is recommended. IMPACT: Early intervention programs are proven to enhance optimal childhood development, yet the vital step of early identification of developmental delays is often overlooked. While machine learning is increasingly used to predict or identify health outcomes, its application in identifying developmental outcomes, particularly in low-resource settings, remains limited. This study contributes to the literature by applying machine learning to identify infants who are developmentally off-track and highlights key predictors. Limited psychosocial stimulation and increasing infant age were the strongest predictors, alongside low socioeconomic status, maternal mental health challenges, limited healthcare access, and nutritional and biological risks. CI - (c) 2026. The Author(s). FAU - Benson, Faith Neema AU - Benson FN AD - Institute for Human Development, Aga Khan University, Nairobi, Kenya. faith.neema@aku.edu. AD - Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa. faith.neema@aku.edu. FAU - Odhiambo, Rachel AU - Odhiambo R AD - Institute for Human Development, Aga Khan University, Nairobi, Kenya. FAU - Ngugi, Anthony K AU - Ngugi AK AD - Department of Population Health, Medical College, Aga Khan University, Nairobi, Kenya. FAU - Brink, Willie AU - Brink W AD - Department of Mathematical Sciences, Stellenbosch University, Stellenbosch, South Africa. FAU - Waljee, Akbar K AU - Waljee AK AD - Department of Learning Health Sciences, University of Michigan, Ann Arbor, MI, USA. AD - Center for Global Health Equity, University of Michigan, Ann Arbor, MI, USA. FAU - Moyer, Cheryl A AU - Moyer CA AD - Department of Learning Health Sciences, University of Michigan, Ann Arbor, MI, USA. AD - Center for Global Health Equity, University of Michigan, Ann Arbor, MI, USA. FAU - Zhu, Ji AU - Zhu J AD - Department of Statistics, University of Michigan, Ann Arbor, MI, USA. FAU - Agoi, Felix AU - Agoi F AD - Environmental Health and Governance Centre, Africa International University, Nairobi, Kenya. FAU - Abubakar, Amina AU - Abubakar A AD - Institute for Human Development, Aga Khan University, Nairobi, Kenya. AD - Department of Psychiatry, University of Oxford, Oxford, UK. AD - Neuroscience Unit, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya. LA - eng PT - Journal Article DEP - 20260130 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 SB - IM MH - Humans MH - Infant MH - Kenya MH - Cross-Sectional Studies MH - *Machine Learning MH - Resource-Limited Settings MH - *Child Development MH - Female MH - Infant, Newborn MH - Random Forest MH - Predictive Learning Models MH - Boosting Machine Learning Algorithms MH - Male MH - Logistic Models MH - Classification Algorithms MH - ROC Curve MH - *Developmental Disabilities/diagnosis MH - Prediction Algorithms PMC - PMC13672098 COIS- Competing interests: The authors declare no competing interests. Ethics approval: The primary project was approved by the Aga Khan University, Nairobi Institutional Scientific and Ethics Review Committee (Ref: 2022/ISERC_75(V2)). Permission to conduct the study in Kenya was granted by the National Commission for Science, Technology, and Innovation (Ref: 2322698). A local permit to conduct the study was granted by the research office in Kilifi (Ref: KLF/DOH/RESEARCH/VOL.1/004). All participants provided written informed consent for their participation. EDAT- 2026/01/31 00:29 MHDA- 2026/10/16 05:32 PMCR- 2026/01/30 CRDT- 2026/01/30 23:22 PHST- 2025/07/23 00:00 [received] PHST- 2025/12/22 00:00 [accepted] PHST- 2025/11/25 00:00 [revised] PHST- 2026/10/16 05:32 [medline] PHST- 2026/01/31 00:29 [pubmed] PHST- 2026/01/30 23:22 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - 10.1038/s41390-026-04761-7 [pii] AID - 4761 [pii] AID - 10.1038/s41390-026-04761-7 [doi] PST - ppublish SO - Pediatr Res. 2026 Aug;100(3):1100-1108. doi: 10.1038/s41390-026-04761-7. Epub 2026 Jan 30. PMID- 41615869 OWN - NLM STAT- MEDLINE DCOM- 20260604 LR - 20260818 IS - 1421-9697 (Electronic) IS - 0250-6807 (Linking) VI - 82 IP - 3 DP - 2026 TI - Association between Arterial Stiffness and Obesity Indicators: A Comparative Study of Traditional and Novel Anthropometric Measures in Northern Chinese. PG - 164-176 LID - 10.1159/000550364 [doi] AB - INTRODUCTION: Arterial stiffness (AS) is a well-established independent predictor of cardiovascular events and all-cause mortality. However, limited studies have examined the comparative predictive performance of traditional obesity indicators (BMI, WC) versus novel indices (WWI, ABSI, BRI, CI) for AS. METHODS: This study utilized baseline data from the Shaanxi cohort of the Regional Ethnic Cohort Study in Northwest China (RECS). Anthropometric measurements were collected to calculate obesity indicators, and estimated pulse wave velocity (ePWV) served as a surrogate for AS. Logistic regression and restricted cubic spline models assessed the associations and dose-response relationships between obesity indicators and ePWV. Receiver operating characteristic curves were used to compare the predictive performance of these indicators. RESULTS: After adjusting for confounders, all obesity indices exhibited significant positive nonlinear associations with ePWV (p for nonlinearity < 0.001). Participants with overweight (OR = 1.63, 95% CI: 1.51-1.77) or obesity (OR = 2.13, 95% CI: 1.90-2.40) had a higher risk of elevated ePWV compared to those with normal BMI. Central adiposity (based on WC) was associated with a 70% increased risk (OR = 1.70, 95% CI: 1.58-1.83). Similarly, individuals in the highest quartile (Q4) of WWI, ABSI, BRI, and CI showed 1.40-, 1.14-, 2.24-, and 1.52-fold higher risks of elevated ePWV, respectively, compared to the lowest quartile (Q1). Novel obesity indices demonstrated superior predictive performance over traditional measures, with WWI exhibiting the strongest discriminative ability. CONCLUSIONS: Obesity significantly increases AS risk in Chinese adults, and novel obesity indicators (particularly WWI) could outperform BMI and WC in predicting AS. Managing abdominal obesity and reducing visceral adiposity may mitigate AS risk, thereby lowering the likelihood of cardiovascular disease. CI - (c) 2026 S. Karger AG, Basel. FAU - Li, Zongkai AU - Li Z AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China. FAU - Lin, Xiaoyan AU - Lin X AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China. FAU - Lin, Jie AU - Lin J AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China. FAU - Huang, Yan AU - Huang Y AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China. FAU - Jing, Hui AU - Jing H AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China. FAU - Chacha, Samuel AU - Chacha S AD - Department of Molecular Diagnostics, Sumbwanga Regional Referral Hospital, Rukwa, Tanzania. FAU - Shen, Yuan AU - Shen Y AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China. FAU - Kang, Yijun AU - Kang Y AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China. FAU - Wang, Duolao AU - Wang D AD - Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, UK. FAU - Yan, Hong AU - Yan H AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China. FAU - Dang, Shaonong AU - Dang S AD - Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, China, tjdshn@mail.xjtu.edu.cn. AD - Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education, Xi'an, China, tjdshn@mail.xjtu.edu.cn. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260130 PL - Switzerland TA - Ann Nutr Metab JT - Annals of nutrition & metabolism JID - 8105511 RN - Chinese people SB - IM MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Adiposity MH - Anthropometry MH - Body Mass Index MH - Cardiovascular Diseases MH - China/epidemiology MH - Cohort Studies MH - *Obesity/physiopathology/epidemiology MH - Obesity, Abdominal/physiopathology MH - Pulse Wave Analysis MH - Risk Factors MH - *Vascular Stiffness/physiology MH - Waist Circumference MH - *East Asian People/statistics & numerical data MH - Young Adult MH - Aged MH - Adolescent OTO - NOTNLM OT - Arterial stiffness OT - Estimated pulse wave velocity OT - Novel indices OT - Traditional obesity indicators EDAT- 2026/01/30 20:01 MHDA- 2026/06/04 06:34 CRDT- 2026/01/30 13:23 PHST- 2025/05/29 00:00 [received] PHST- 2026/01/02 00:00 [accepted] PHST- 2026/06/04 06:34 [medline] PHST- 2026/01/30 20:01 [pubmed] PHST- 2026/01/30 13:23 [entrez] AID - 000550364 [pii] AID - 10.1159/000550364 [doi] PST - ppublish SO - Ann Nutr Metab. 2026;82(3):164-176. doi: 10.1159/000550364. Epub 2026 Jan 30. PMID- 41615635 OWN - NLM STAT- MEDLINE DCOM- 20260619 LR - 20260813 IS - 2212-1358 (Electronic) IS - 2212-134X (Print) IS - 2212-134X (Linking) VI - 14 IP - 3 DP - 2026 May TI - Artificial intelligence-driven 3D surface-topography app for screening and monitoring adolescent scoliosis: early results from a single institution. PG - 851-858 LID - 10.1007/s43390-026-01282-5 [doi] AB - PURPOSE: Radiation-free tools, such as scoliometers, ultrasound, and Moire topography, have been explored for monitoring Adolescent Idiopathic Scoliosis (AIS), but none have replaced the need for serial spinal radiographs. This study aimed to evaluate the accuracy and criterion validity of a new AI-powered digital health application using 3D surface topography to predict Cobb angles, with the goal of reducing radiation exposure and enabling home-based curve monitoring. METHODS: In a single-center observational study, 125 patients with confirmed or suspected scoliosis underwent smartphone-based 3D surface-topography scans in standing and forward-bending positions. Poor-quality scans (n = 20) were excluded. Radiographic Cobb angles were used as the gold standard. After random allocation, 79 scans formed the training set and 26 formed the validation set; external data (142 controls, 188 scoliosis patients) were added to strengthen training, and 25 controls were added to the test set. Accuracy was expressed as mean absolute error (MAE) and correlation with radiographs. Criterion validity was assessed by sensitivity, specificity, and AUC at clinically meaningful thresholds (10 degrees , 25 degrees , and 40 degrees ). RESULTS: Across 51 test scans (AIS + controls), the algorithm showed a strong correlation with radiographs (r = 0.922, 95% CI 0.866-0.955) and an MAE of 5.9 degrees (95% CI 4.5-7.3). In AIS-only curves of 10-50 degrees , the MAE was 6.4 degrees (95% CI 4.4-8.3). At 10 degrees , sensitivity was 0.962, specificity was 0.960, and AUC was 0.978. At 25 degrees , sensitivity was 0.706, specificity was 0.853, and AUC was 0.917. At 40 degrees , sensitivity was 0.667, specificity was 1.000, and AUC was 1.000. CONCLUSION: This AI-driven 3D surface topography demonstrated high validity for non-radiographic Cobb angle prediction, particularly in mild-to-moderate AIS. It supports safer, more frequent, home-based monitoring, though refinements are needed for severe curves and patients with a higher BMI. CI - (c) 2026. The Author(s). FAU - Parent, Stefan AU - Parent S AUID- ORCID: 0000-0002-4854-2816 AD - Centre de Recherche Azrieli du CHU Sainte-Justine, Montreal, QC, Canada. stefan.parent@umontreal.ca. AD - Division of Orthopaedics, Department of Surgery, CHU Sainte-Justine, Montreal, QC, Canada. stefan.parent@umontreal.ca. AD - Department of Surgery, University of Montreal, Montreal, QC, Canada. stefan.parent@umontreal.ca. FAU - Roy-Beaudry, Marjolaine AU - Roy-Beaudry M AUID- ORCID: 0009-0003-7050-9849 AD - Centre de Recherche Azrieli du CHU Sainte-Justine, Montreal, QC, Canada. FAU - Dufresne, Justin AU - Dufresne J AD - Centre de Recherche Azrieli du CHU Sainte-Justine, Montreal, QC, Canada. FAU - Imbeault, Rachelle AU - Imbeault R AUID- ORCID: 0009-0005-0365-9921 AD - Centre de Recherche Azrieli du CHU Sainte-Justine, Montreal, QC, Canada. FAU - Barchi, Soraya AU - Barchi S AD - Centre de Recherche Azrieli du CHU Sainte-Justine, Montreal, QC, Canada. FAU - Beausejour, Marie AU - Beausejour M AUID- ORCID: 0000-0003-3180-3642 AD - Centre de Recherche Azrieli du CHU Sainte-Justine, Montreal, QC, Canada. AD - Department of Surgery, University of Montreal, Montreal, QC, Canada. AD - Department of Community Health Sciences, Universite de Sherbrooke, Sherbrooke, Canada. LA - eng PT - Journal Article PT - Observational Study DEP - 20260130 PL - England TA - Spine Deform JT - Spine deformity JID - 101603979 SB - IM MH - Humans MH - *Scoliosis/diagnostic imaging/diagnosis MH - Adolescent MH - Female MH - *Artificial Intelligence MH - *Imaging, Three-Dimensional/methods MH - Male MH - Sensitivity and Specificity MH - Reproducibility of Results MH - *Mobile Applications MH - Child MH - Radiography MH - Smartphone PMC - PMC13282326 OTO - NOTNLM OT - 3D surface topography OT - Adolescent idiopathic scoliosis OT - Artificial intelligence OT - Cobb angle OT - Digital health OT - Radiation-free monitoring COIS- Declarations. Conflict of interest: MRB, RI, JD, and SB declare that they have no conflict of interest. MB has received funding PROMPT-IA with Momentum, Mitacs Accelerate International Student Grant. Fonds de Recherche du Quebec en Sante Junior-2 Salary Award (2022-2026). SP has received outside the submitted work: royalties from EOS imaging, he is a co-founder of the company Spinologics Inc., he received consultancy fees from K2M, Medtronic and DePuy Synthes Spine, he received grants from DePuy Synthes Spine, Canadian Institutes of Health Research, Pediatric Orthopaedic Society of North America, Scoliosis Research Society, Medtronic, EOS imaging, Canadian Foundation for Innovation, Setting Scoliosis Straight Foundation, Natural Sciences and Engineering Council of Canada, Fonds de recherche Quebec-Sante, grants, and the Orthopaedic Research and Education Foundation, he received fellowship support from DePuy Synthes and Medtronic, he is the holder of the Academic Chair in Pediatric Spinal Deformities at CHU Ste-Justine, and he is a member of the speaker bureau of Orthopaediatrics. Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committees and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the ethics committee of the CHU Sainte-Justine. Consent to participate: All research participants or their legal guardians provided written consent to be part of the database and to have the data collected used in ongoing research on scoliosis. Consent for publication: We obtained consent from the responsible authorities to submit this scientific work. EDAT- 2026/01/30 13:18 MHDA- 2026/06/19 12:36 PMCR- 2026/01/30 CRDT- 2026/01/30 11:25 PHST- 2025/09/26 00:00 [received] PHST- 2026/01/10 00:00 [accepted] PHST- 2026/06/19 12:36 [medline] PHST- 2026/01/30 13:18 [pubmed] PHST- 2026/01/30 11:25 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - 10.1007/s43390-026-01282-5 [pii] AID - 1282 [pii] AID - 10.1007/s43390-026-01282-5 [doi] PST - ppublish SO - Spine Deform. 2026 May;14(3):851-858. doi: 10.1007/s43390-026-01282-5. Epub 2026 Jan 30. PMID- 41615545 OWN - NLM STAT- MEDLINE DCOM- 20260318 LR - 20260813 IS - 1573-6695 (Electronic) IS - 1389-4986 (Print) IS - 1389-4986 (Linking) VI - 27 IP - 2 DP - 2026 Feb TI - Validation of the Observational Assessment Tool for Tailoring (OATT). PG - 316-332 LID - 10.1007/s11121-026-01879-2 [doi] AB - Individually tailored interventions can address the myriad multi-level determinants of chronic health conditions. Limited measurement modalities to quantify tailoring disallow examining "active ingredient" effects on outcomes and implementation fidelity. The objective of this study is to develop and validate the Observational Assessment Tool for Tailoring (OATT) for behavioral prevention interventions. We developed the OATT and coded n = 172 videorecorded sessions from two trials of the Family Check-Up(R) 4 Health (FCU4Health), an individually tailored prevention and management program for behavioral health and obesogenic behaviors with English and Spanish-speaking participants. The sample was culturally diverse (> 65% Hispanic/Latino). Confirmatory factor analysis (CFA) tested the two-factor model. McDonald's Omega estimated internal consistency. Discriminant and predictive validity tests were conducted with FCU4Health fidelity, engagement, and health behavior outcomes, informed by the Implementation Cascade Model. CFA confirmed a two-factor structure for both trials (i.e., RMSEA /= 0.95, SRMR < 0.08 chi-square p >/= 0.05). Reliability and inter-rater reliability were good (ICC > 0.77) for both trials and English and Spanish videos. The OATT was not correlated (p > 0.05) with discriminant validity variables. Path analysis for predictive validity indicated that fidelity to the Individualized Treatment Planning factor directly predicts improvements in participant engagement (B = 0.16, p = 0.01, 95% CI [0.03-0.29]), which directly predicts improvements in parent health behaviors 12 months post-baseline (B = 0.18, p = 0.01, 95% CI [0.02-0.34]). The development of the OATT is a critical step to measure and guide tailored intervention development, implementation, and evaluation. Future studies are needed to replicate predictive validity findings and test the OATT factor structure with larger samples and different prevention initiatives. CI - (c) 2026. The Author(s). FAU - Fu, Emily S AU - Fu ES AUID- ORCID: 0000-0002-9070-2975 AD - Departments of Medicine & Psychiatry and Behavioral Neuroscience, The University of Chicago, Chicago, USA. efu@uchicago.edu. AD - Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. efu@uchicago.edu. FAU - Merle, James L AU - Merle JL AD - Department of Population Health Sciences, Division of Health System Innovation and Research, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA. FAU - Berkel, Cady AU - Berkel C AUID- ORCID: 0000-0001-9664-9485 AD - College of Health Solutions, Arizona State University, Phoenix, AZ, USA. FAU - Brown, C Hendricks AU - Brown CH AD - Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. FAU - Philbin, Sarah AU - Philbin S AD - Health Sciences Integrated PhD Program, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. FAU - Fan, Yiqing AU - Fan Y AD - Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. AD - Department of Psychology, American University, Washington, DC, USA. FAU - McGinnis, Jenna L AU - McGinnis JL AD - Department of Educational Psychology, University of Utah, Salt Lake City, UT, USA. FAU - Demauro, Dania AU - Demauro D AD - College of Health Solutions, Arizona State University, Phoenix, AZ, USA. FAU - DiGregorio, Ariana AU - DiGregorio A AD - College of Health Solutions, Arizona State University, Phoenix, AZ, USA. FAU - Litchey, Janeth AU - Litchey J AD - College of Health Solutions, Arizona State University, Phoenix, AZ, USA. FAU - Smith, Justin D AU - Smith JD AD - Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. AD - Department of Population Health Sciences, Division of Health System Innovation and Research, Spencer Fox Eccles School of Medicine, University of Utah, Salt Lake City, UT, USA. LA - eng GR - F31HL160534/NHLBI Division of Intramural Research/ GR - F31 HL160534/HL/NHLBI NIH HHS/United States GR - U18DP006255/CC/CDC HHS/United States GR - 2018-68001-27550/U.S. Department of Agriculture/ GR - U18 DP006255/DP/NCCDPHP CDC HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Validation Study DEP - 20260130 PL - United States TA - Prev Sci JT - Prevention science : the official journal of the Society for Prevention Research JID - 100894724 SB - IM MH - Adult MH - Female MH - Humans MH - Male MH - *Health Behavior MH - Middle Aged MH - Randomized Controlled Trials as Topic MH - Health Promotion MH - *Health Impact Assessment/methods PMC - PMC12999605 OTO - NOTNLM OT - Behavior change OT - Implementation fidelity OT - Measurement development OT - Pediatric obesity OT - Tailoring COIS- Declarations. Ethical Approval: This study was designed in accordance with the basic ethical principles of autonomy, beneficence, justice, and non-maleficence and conducted in accordance with the rules of Good Clinical Practice outlined in the most recent Declaration of Helsinki. The study was approved by the Institutional Review Board (IRB) of Northwestern University (STU00215542). The two FCU4Health trials (ethics approval numbers: STUDY00012412; STUDY00009621) and all procedures were reviewed and approved by the Arizona State University IRB. All other participating institutions provided signed reliance agreements ceding to the IRB of Arizona State University. Informed Consent: Consent and assent were obtained from all participants included in the study. Conflict of interest: Cady Berkel and Justin D. Smith co-developed the Family Check-Up 4 Health program. The other authors have no potential conflicts of interest to declare. Clinical Trial Number: This is a secondary analysis using data from the following two clinical trial registration numbers: NCT03013309 ClinicalTrials.gov and NCT04469816 ClinicalTrials.gov. EDAT- 2026/01/30 13:19 MHDA- 2026/03/18 18:36 PMCR- 2026/01/30 CRDT- 2026/01/30 11:21 PHST- 2025/06/20 00:00 [received] PHST- 2026/01/16 00:00 [accepted] PHST- 2026/03/18 18:36 [medline] PHST- 2026/01/30 13:19 [pubmed] PHST- 2026/01/30 11:21 [entrez] PHST- 2026/01/30 00:00 [pmc-release] AID - 10.1007/s11121-026-01879-2 [pii] AID - 1879 [pii] AID - 10.1007/s11121-026-01879-2 [doi] PST - ppublish SO - Prev Sci. 2026 Feb;27(2):316-332. doi: 10.1007/s11121-026-01879-2. Epub 2026 Jan 30. PMID- 41613926 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260130 LR - 20260201 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Association between the Infant and Child Feeding Index at 8 months and early childhood neurodevelopment. PG - 1727649 LID - 10.3389/fnut.2025.1727649 [doi] LID - 1727649 AB - OBJECTIVE: To evaluate the association between infant feeding practices, measured by the Infant and Child Feeding Index (ICFI) at 8 months, and early childhood neurodevelopment. METHODS: A total of 705 participants were enrolled from the Shenzhen Birth Cohort Study (SZBC), a prospective longitudinal study. Infant feeding practices at 8 months were assessed via a validated dietary recall method combining 24 h and 7 day recall records. ICFI scores were calculated based on seven components (including breastfeeding and complementary feeding) and dichotomized into qualified (>60% of the total score) versus unqualified groups. Neurodevelopment was evaluated across five domains using the Ages and Stages Questionnaire, Third Edition (ASQ-3) at 8, 12, 18, and 24 months. Multivariable Generalized Estimating Equations (GEE) analyzed the association between ICFI status at 8 months and neurodevelopmental delay across early childhood. RESULTS: At 8 months, 48.5% of infants had qualified ICFI scores. Across the five ASQ-3 domains, the prevalence of developmental delay between 8 and 24 months ranged from 1.0 to 16.8%. After controlling for confounders, infants in the qualified ICFI group exhibited significantly lower odds of delay in the communication domain (OR = 0.51; 95% CI: 0.35-0.75), the problem-solving domain (OR = 0.55; 95% CI: 0.32-0.95), and the personal-social domain (OR = 0.54; 95% CI: 0.37-0.79). CONCLUSION: Higher ICFI scores at 8 months, indicating healthier feeding practices, are associated with reduced risk of neurodevelopmental delays through age two. These findings underscore the importance of promoting targeted feeding guidelines to support early childhood development. CI - Copyright (c) 2026 Li, Zhang, Dai, Liu, Gao, Liu, Wei and Cai. FAU - Li, Xiuxiu AU - Li X AD - Nanshan Maternity & Child Healthcare Hospital of Shenzhen, Shenzhen, China. FAU - Zhang, Jianan AU - Zhang J AD - Tianhe District Center for Disease Control and Prevention of Guangzhou, Guangzhou, China. FAU - Dai, Xiaowei AU - Dai X AD - Nanshan Maternity & Child Healthcare Hospital of Shenzhen, Shenzhen, China. FAU - Liu, Xuemei AU - Liu X AD - Nanshan Maternity & Child Healthcare Hospital of Shenzhen, Shenzhen, China. FAU - Gao, Rui AU - Gao R AD - Shenzhen Cadre and Talent Health Management Center, Shenzhen, China. FAU - Liu, Xuhua AU - Liu X AD - Nanshan Maternity & Child Healthcare Hospital of Shenzhen, Shenzhen, China. FAU - Wei, Min AU - Wei M AD - Nanshan Maternity & Child Healthcare Hospital of Shenzhen, Shenzhen, China. FAU - Cai, Li AU - Cai L AD - Sun Yat-sen University, Guangzhou, China. LA - eng PT - Journal Article DEP - 20260114 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12846993 OTO - NOTNLM OT - Food Frequency Questionnaire OT - ICFI OT - birth cohort OT - feeding practice OT - neurodevelopment COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/30 06:30 MHDA- 2026/01/30 06:31 PMCR- 2026/01/14 CRDT- 2026/01/30 04:47 PHST- 2025/10/18 00:00 [received] PHST- 2025/11/30 00:00 [revised] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/01/30 06:31 [medline] PHST- 2026/01/30 06:30 [pubmed] PHST- 2026/01/30 04:47 [entrez] PHST- 2026/01/14 00:00 [pmc-release] AID - 10.3389/fnut.2025.1727649 [doi] PST - epublish SO - Front Nutr. 2026 Jan 14;12:1727649. doi: 10.3389/fnut.2025.1727649. eCollection 2025. PMID- 41613840 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260130 LR - 20260201 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 16 DP - 2025 TI - Social media use and disordered eating in young adults: the protective and risk pathways of physical activity and body image. PG - 1699756 LID - 10.3389/fpsyg.2025.1699756 [doi] LID - 1699756 AB - BACKGROUND/OBJECTIVES: Social media is a pervasive force in youth culture, shaping body perception and dietary habits. However, the psychological and behavioral pathways linking social media use to eating behavior remain insufficiently understood. This study examined the mediating roles of body image dissatisfaction and physical activity in the association between social media use and dietary behavior among young adults. METHODS: A cross-sectional survey was conducted among 422 Chinese university students (Mean age = 22.82 +/- 2.42) between November 2024 and February 2025. Participants completed validated measures of social media use, body image dissatisfaction (BSQ-16), physical activity (IPAQ-SF), and dietary behavior (DEBQ). Data were analyzed using confirmatory factor analysis (CFA), parallel mediation modeling (PROCESS macro), and ANOVA for subgroup comparisons. RESULTS: Confirmatory factor analysis confirmed the measurement model (CFI = 0.926, RMSEA = 0.057). Social media use significantly predicted higher body image dissatisfaction (beta = 0.578, p < 0.001) and lower physical activity (beta = -348.717, p < 0.001), both of which were associated with disordered eating (beta = 0.442 and beta = -0.000, respectively). Parallel mediation analysis identified two significant indirect effects: through body image dissatisfaction (indirect effect = 0.256, p < 0.001) and physical activity (indirect effect = 0.084, p < 0.001). ANOVA showed that lower physical activity was associated with higher social media use and poorer dietary outcomes. CONCLUSION: Social media is associated with dietary behavior through dual psychological and behavioral pathways. Interventions should target body image resilience and active lifestyles to mitigate the health risks posed by digital media environments. CI - Copyright (c) 2026 Yu, Cui, Liu, Wang, Li and Lipowski. FAU - Yu, Wei AU - Yu W AD - School of Sport Education, Tianjin University of Sport, Tianjin, China. AD - Faculty of Sports and Arts, Harbin Sport University, Harbin, China. FAU - Cui, Liwen AU - Cui L AD - Department of Physical Education, Heilongjiang University of Science and Technology, Harbin, China. FAU - Liu, Changli AU - Liu C AD - School of Sport Education, Tianjin University of Sport, Tianjin, China. FAU - Wang, Jian AU - Wang J AD - College of Physical Education, Qinghai Minzu University, Xining, China. FAU - Li, Jianye AU - Li J AD - Faculty of Physical Education, Gdansk University of Physical Education and Sport, Gdansk, Poland. AD - Department of Physical Education, Shanxi Medical University, Jinzhong, China. FAU - Lipowski, Mariusz AU - Lipowski M AD - Faculty of Social and Humanities, WSB Merito University in Gdansk, Gdansk, Poland. LA - eng PT - Journal Article DEP - 20260114 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12847240 OTO - NOTNLM OT - body image dissatisfaction OT - dietary behavior OT - parallel mediation model OT - physical activity OT - social media use COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/30 06:30 MHDA- 2026/01/30 06:31 PMCR- 2026/01/14 CRDT- 2026/01/30 04:46 PHST- 2025/09/08 00:00 [received] PHST- 2025/12/09 00:00 [revised] PHST- 2025/12/18 00:00 [accepted] PHST- 2026/01/30 06:31 [medline] PHST- 2026/01/30 06:30 [pubmed] PHST- 2026/01/30 04:46 [entrez] PHST- 2026/01/14 00:00 [pmc-release] AID - 10.3389/fpsyg.2025.1699756 [doi] PST - epublish SO - Front Psychol. 2026 Jan 14;16:1699756. doi: 10.3389/fpsyg.2025.1699756. eCollection 2025. PMID- 41613613 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260130 LR - 20260201 IS - 2976-5390 (Electronic) IS - 2976-5390 (Linking) VI - 4 IP - 1 DP - 2026 Jan TI - Development and validation of a 1-item very low food security screen. PG - qxag007 LID - 10.1093/haschl/qxag007 [doi] LID - qxag007 AB - INTRODUCTION: The Centers for Medicare and Medicaid Services has made screening for health-related social needs (HRSNs) mandatory since 2024. Patients screening positive for HRSN food insecurity (FI) are connected with Supplemental Nutrition Services using 1115 Demonstration waivers. With a shift in funding, Massachusetts adopted a more stringent FI-level screening protocol (very low food security [VLFS]). To date, there is no screening tool that identifies VLFS alone; thus, we developed a sensitive, specific, and valid screen to determine risk for VLFS. METHODS: Sensitivity, specificity, and positive- and negative-predictive values were used to test combinations of questions compared with the USDA Household Food Security Survey Module using the 2022 Current Population Survey. RESULTS: The best VLFS screen was, "In the last 12 months, did you or other adults in your household ever cut the size of your meals or skip meals because there wasn't enough money for food?" (yes/no). The screen was highly sensitive, specific, and valid for detecting VLFS risk in US households with and without children (sensitivity, 92.2% and 97.2%; specificity, 96.2% and 97.4%, respectively), and with diverse populations. CONCLUSION: The VLFS screen is recommended for use by states adopting a more stringent FI-level screening protocol. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of Project HOPE - The People-To-People Health Foundation, Inc. FAU - Poblacion, Ana AU - Poblacion A AUID- ORCID: 0000-0002-5202-3728 AD - Department of Pediatrics, Boston Medical Center, Boston, MA 02119, United States. AD - Department of Pediatrics, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02119, United States. FAU - Sheward, Richard AU - Sheward R AD - Department of Pediatrics, Boston Medical Center, Boston, MA 02119, United States. AD - Department of Pediatrics, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02119, United States. FAU - Ettinger de Cuba, Stephanie AU - Ettinger de Cuba S AUID- ORCID: 0000-0003-1789-1009 AD - Department of Pediatrics, Boston University Chobanian and Avedisian School of Medicine, Boston, MA 02119, United States. AD - Department of Health Law, Policy and Management, Boston University School of Public Health, Boston, MA 02118, United States. LA - eng PT - Journal Article DEP - 20260119 PL - England TA - Health Aff Sch JT - Health affairs scholar JID - 9918627882906676 PMC - PMC12849366 OTO - NOTNLM OT - food insecurity OT - health-related social needs OT - hunger OT - nutrition OT - screening tool COIS- Conflicts of interest: Please see ICMJE form(s) for author conflicts of interest. These have been provided as supplementary materials. EDAT- 2026/01/30 06:28 MHDA- 2026/01/30 06:29 PMCR- 2026/01/19 CRDT- 2026/01/30 04:44 PHST- 2025/11/12 00:00 [received] PHST- 2025/12/22 00:00 [revised] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/01/30 06:29 [medline] PHST- 2026/01/30 06:28 [pubmed] PHST- 2026/01/30 04:44 [entrez] PHST- 2026/01/19 00:00 [pmc-release] AID - qxag007 [pii] AID - 10.1093/haschl/qxag007 [doi] PST - epublish SO - Health Aff Sch. 2026 Jan 19;4(1):qxag007. doi: 10.1093/haschl/qxag007. eCollection 2026 Jan. PMID- 41613124 OWN - NLM STAT- MEDLINE DCOM- 20260204 LR - 20260204 IS - 1664-3224 (Electronic) IS - 1664-3224 (Linking) VI - 16 DP - 2025 TI - Diagnostic biomarkers for differentiating AQP4-IgG- negative NMOSD from other nervous system autoimmune disorders: a retrospective study. PG - 1637613 LID - 10.3389/fimmu.2025.1637613 [doi] LID - 1637613 AB - BACKGROUND AND OBJECTIVE: The clinical manifestations of neuromyelitis optica spectrum disorders (NMOSD) overlap with those of other central nervous system (CNS) disorders, making differential diagnosis based on symptoms alone difficult. This study aimed to identify distinguishing indicators of aquaporin-4 (AQP4) IgG-negative NMOSD and assess their diagnostic value. METHODS: We analyzed four groups: 85 patients with AQP4-IgG-negative NMOSD, 192 with AQP4-IgG-positive NMOSD, 547 with other nervous system autoimmune disorders (e.g., multiple sclerosis, Guillain-Barre syndrome, and viral and autoimmune encephalitis), and 269 healthy controls matched for sex, age, and BMI.A diagnostic model was established using clinical, biochemical, and cerebrospinal fluid (CSF) variables. The dataset was divided into training and internal validation cohorts, and model performance was further assessed through external validation using an independently collected dataset obtained during the same study period. RESULTS: We enrolled 1,093 participants. The AQP4-IgG-negative NMOSD group showed: higher diplopia incidence (35.29% vs. 17.19% in positive NMOSD, 17.18% in controls; P<0.001); lower limb sensory abnormalities (76.47% vs. 89.58%, P = 0.0056) and urinary dysfunction (36.47% vs. 57.29%, P = 0.0017) than positive cases; predominant brainstem involvement (50.59% vs. 31.77% in positive, 28.70% in controls; P<0.001); moderate spinal cord involvement (70.59% vs. 88.02% in positive, 38.57% in controls; P<0.001); and altered thyroxine, apolipoprotein A1, eosinophils, and basophils. After false discovery rate correction (q<0.1), diplopia, brainstem involvement, spinal cord involvement, serum albumin, and CSF albumin remained significant. A combined model incorporating twelve predictors (Ocular symptoms, Gastrointestinal symptoms, Water swallowing and choking difficulties, Cerebral lobes, Centrum semiovale, Brainstem, Cerebral ganglia, Spinal cord, APOA1, Ca, Toxoplasma gondii IgM Antibody, CSF IgG) achieved an AUC of 0.936in the training cohort and 0.929 in external validation. DISCUSSION: AQP4-IgG-negative NMOSD shows distinct clinical, imaging, and laboratory profiles compared to other nervous system autoimmune disorders. A multi-indicator diagnostic approach offers higher accuracy than single-marker diagnostics. CI - Copyright (c) 2026 Jiang, Jiao, Zhang, Wang, Li, Chen, Ding, Li, Wang, Li, Liu, Huang, Liu and Zhang. FAU - Jiang, Wencan AU - Jiang W AD - Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - Beijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, China. AD - NMPA Key Laboratory for Quality Control of In Vitro Diagnostic, Beijing, China. AD - Laboratory Diagnosis Platform for Nervous System Infectious Diseases, Laboratory for Clinical Medicine, Capital Medical University, Beijing, China. FAU - Jiao, Yang AU - Jiao Y AD - Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - Beijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, China. AD - NMPA Key Laboratory for Quality Control of In Vitro Diagnostic, Beijing, China. AD - Laboratory Diagnosis Platform for Nervous System Infectious Diseases, Laboratory for Clinical Medicine, Capital Medical University, Beijing, China. FAU - Zhang, Menglue AU - Zhang M AD - Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - Beijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, China. AD - NMPA Key Laboratory for Quality Control of In Vitro Diagnostic, Beijing, China. AD - Laboratory Diagnosis Platform for Nervous System Infectious Diseases, Laboratory for Clinical Medicine, Capital Medical University, Beijing, China. FAU - Wang, Chenxu AU - Wang C AD - Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - Laboratory Diagnosis Platform for Nervous System Infectious Diseases, Laboratory for Clinical Medicine, Capital Medical University, Beijing, China. FAU - Li, Xiaotong AU - Li X AD - Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - Beijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, China. AD - Laboratory Diagnosis Platform for Nervous System Infectious Diseases, Laboratory for Clinical Medicine, Capital Medical University, Beijing, China. FAU - Chen, Kelin AU - Chen K AD - Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - Beijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, China. AD - NMPA Key Laboratory for Quality Control of In Vitro Diagnostic, Beijing, China. AD - Laboratory Diagnosis Platform for Nervous System Infectious Diseases, Laboratory for Clinical Medicine, Capital Medical University, Beijing, China. FAU - Ding, Yaowei AU - Ding Y AD - Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - Beijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, China. AD - NMPA Key Laboratory for Quality Control of In Vitro Diagnostic, Beijing, China. AD - Laboratory Diagnosis Platform for Nervous System Infectious Diseases, Laboratory for Clinical Medicine, Capital Medical University, Beijing, China. FAU - Li, Haoran AU - Li H AD - Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - Beijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, China. AD - NMPA Key Laboratory for Quality Control of In Vitro Diagnostic, Beijing, China. AD - Laboratory Diagnosis Platform for Nervous System Infectious Diseases, Laboratory for Clinical Medicine, Capital Medical University, Beijing, China. FAU - Wang, Lijuan AU - Wang L AD - Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - Beijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, China. AD - NMPA Key Laboratory for Quality Control of In Vitro Diagnostic, Beijing, China. AD - Laboratory Diagnosis Platform for Nervous System Infectious Diseases, Laboratory for Clinical Medicine, Capital Medical University, Beijing, China. FAU - Li, Siwen AU - Li S AD - Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - Beijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, China. AD - NMPA Key Laboratory for Quality Control of In Vitro Diagnostic, Beijing, China. AD - Laboratory Diagnosis Platform for Nervous System Infectious Diseases, Laboratory for Clinical Medicine, Capital Medical University, Beijing, China. FAU - Liu, Ziwei AU - Liu Z AD - Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - Beijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, China. AD - NMPA Key Laboratory for Quality Control of In Vitro Diagnostic, Beijing, China. AD - Laboratory Diagnosis Platform for Nervous System Infectious Diseases, Laboratory for Clinical Medicine, Capital Medical University, Beijing, China. FAU - Huang, Chi AU - Huang C AD - Laboratory Diagnosis Platform for Nervous System Infectious Diseases, Laboratory for Clinical Medicine, Capital Medical University, Beijing, China. AD - Department of Biochemistry and Molecular Biology, School of Basic Medicine, Capital Medical University, Youanmen, Beijing, China. FAU - Liu, Lei AU - Liu L AD - Laboratory Diagnosis Platform for Nervous System Infectious Diseases, Laboratory for Clinical Medicine, Capital Medical University, Beijing, China. AD - Department of Biochemistry and Molecular Biology, School of Basic Medicine, Capital Medical University, Youanmen, Beijing, China. FAU - Zhang, Guojun AU - Zhang G AD - Laboratory Diagnosis Center, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. AD - Beijing Engineering Research Center of Immunological Reagents Clinical Research, Beijing, China. AD - NMPA Key Laboratory for Quality Control of In Vitro Diagnostic, Beijing, China. AD - Laboratory Diagnosis Platform for Nervous System Infectious Diseases, Laboratory for Clinical Medicine, Capital Medical University, Beijing, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260114 PL - Switzerland TA - Front Immunol JT - Frontiers in immunology JID - 101560960 RN - 0 (Biomarkers) RN - 0 (AQP4 protein, human) RN - 0 (Aquaporin 4) RN - 0 (Immunoglobulin G) RN - 0 (Autoantibodies) RN - 0 (Lipids) SB - IM MH - Retrospective Studies MH - *Neuromyelitis Optica/blood/diagnostic imaging/immunology MH - Diagnosis, Differential MH - Biomarkers/blood MH - Humans MH - Male MH - Female MH - Child, Preschool MH - Child MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged MH - Aged MH - Aged, 80 and over MH - Case-Control Studies MH - *Aquaporin 4/immunology MH - Immunoglobulin G/blood MH - Magnetic Resonance Imaging MH - Autoantibodies/blood MH - Lipids/blood MH - Logistic Models PMC - PMC12846999 OTO - NOTNLM OT - AQP4-IgG OT - clinical characteristics OT - laboratory examinations OT - magnetic resonance imaging OT - neuromyelitis optica spectrum disorder COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/30 06:28 MHDA- 2026/01/30 06:29 PMCR- 2026/01/14 CRDT- 2026/01/30 04:40 PHST- 2025/05/29 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2025/12/19 00:00 [accepted] PHST- 2026/01/30 06:29 [medline] PHST- 2026/01/30 06:28 [pubmed] PHST- 2026/01/30 04:40 [entrez] PHST- 2026/01/14 00:00 [pmc-release] AID - 10.3389/fimmu.2025.1637613 [doi] PST - epublish SO - Front Immunol. 2026 Jan 14;16:1637613. doi: 10.3389/fimmu.2025.1637613. eCollection 2025. PMID- 41613099 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Negative life events and problematic smartphone use among university students: the mediating role of self-efficacy and the moderating role of physical activity. PG - 1704120 LID - 10.3389/fpubh.2025.1704120 [doi] LID - 1704120 AB - OBJECTIVES: This study explores how negative life events relate to problematic smartphone use among university students and examines whether self-efficacy acts as a mediator and physical activity as a moderator in this relationship. METHODS: A cross-sectional survey was conducted among undergraduates at eight universities in Nanchang, China, from November 2024 to March 2025. Validated instruments were used to assess negative life events (ASLEC), self-efficacy (GSES), physical activity (PARS), and problematic smartphone use (SAS-SV). The sample included 2,680 participants (47.6% male, 52.4% female; mean age = 19.60 years). Statistical analyses included Pearson correlation analysis and PROCESS models for mediation and moderation. RESULTS: Negative life events were positively correlated with problematic smartphone use and negatively correlated with self-efficacy and physical activity. Self-efficacy partially mediated the relationship between negative life events and problematic smartphone use [indirect effect beta = 0.05, 95% CI (0.04, 0.07)], with a significant direct effect. Physical activity attenuated the positive correlation between negative life events and problematic smartphone use (interaction beta = -0.01, p < 0.001). CONCLUSIONS: Negative life events, self-efficacy, physical activity, and problematic smartphone use are interrelated among university students. Enhancing self-efficacy and promoting physical activity may help mitigate problematic smartphone use. However, the cross-sectional design and reliance on self-reports limit causal inference. CI - Copyright (c) 2026 Yang, Huang, Hu, Zhang, Chen, Zhou, Zhu and Xu. FAU - Yang, Chao AU - Yang C AD - Physical Education College, Jiangxi Normal University, Nanchang, China. FAU - Huang, Wenying AU - Huang W AD - Physical Education College, Jiangxi Normal University, Nanchang, China. FAU - Hu, Chang AU - Hu C AD - Physical Education College, Jiangxi Normal University, Nanchang, China. FAU - Zhang, Wen AU - Zhang W AD - Physical Education College, Jiangxi Normal University, Nanchang, China. FAU - Chen, Bin AU - Chen B AD - Physical Education College, Jiangxi Normal University, Nanchang, China. FAU - Zhou, Chi AU - Zhou C AD - Physical Education College, Jiangxi Normal University, Nanchang, China. FAU - Zhu, Dong AU - Zhu D AD - Hunan University of Medicine, Huaihua, Hunan, China. FAU - Xu, Bo AU - Xu B AD - Hunan University of Medicine, Huaihua, Hunan, China. LA - eng PT - Journal Article DEP - 20260114 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - *Self Efficacy MH - *Students/psychology/statistics & numerical data MH - Cross-Sectional Studies MH - *Exercise/psychology MH - Universities MH - Male MH - *Smartphone/statistics & numerical data MH - Young Adult MH - China/epidemiology MH - *Life Change Events MH - Surveys and Questionnaires MH - Adult MH - Adolescent PMC - PMC12847236 OTO - NOTNLM OT - moderated mediation model OT - negative life events OT - physical activity OT - problematic smartphone use OT - self-efficacy COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/30 06:30 MHDA- 2026/01/30 06:31 PMCR- 2026/01/14 CRDT- 2026/01/30 04:40 PHST- 2025/09/12 00:00 [received] PHST- 2025/12/09 00:00 [revised] PHST- 2025/12/18 00:00 [accepted] PHST- 2026/01/30 06:31 [medline] PHST- 2026/01/30 06:30 [pubmed] PHST- 2026/01/30 04:40 [entrez] PHST- 2026/01/14 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1704120 [doi] PST - epublish SO - Front Public Health. 2026 Jan 14;13:1704120. doi: 10.3389/fpubh.2025.1704120. eCollection 2025. PMID- 41613070 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Perceived risk of type 2 diabetes mellitus: predictors of perceived susceptibility among young adults in Jordan. PG - 1722942 LID - 10.3389/fpubh.2025.1722942 [doi] LID - 1722942 AB - OBJECTIVES: The growing burden of type 2 diabetes mellitus among young adults is a global public health problem. This study aimed to explore risk perception of type 2 diabetes mellitus among university students in Jordan and to identify predictors of perceived susceptibility. METHODS: A cross-sectional study that used proportional stratified sampling to recruit 496 third year university students in all fields of study at the University of Jordan. Participants answered online self-administered validated Arabic questionnaire that was designed based on the constructs of the health belief model. Data was analyzed using Statistical Package for Social Sciences (SPSS) software. RESULTS: The participants in this study evidently underestimated their risk of developing T2DM. Only 25% of students believed that they have high potential of developing T2DM in the future. Perceived susceptibility was low to moderate; it scored lowest among all dimensions of risk perception (mean = 2.86 out of 5). Results of t-test and ANOVA showed that perceived susceptibility was higher among students in engineering and science (p = 0.001), males (p = 0.019), with higher income (p = 0.008), overweight (p = 0.026), and students with little knowledge of T2DM (p = 0.027). Results of logistic regression indicated that high income level was the only significant predictor of higher perceived susceptibility (OR = 2.7. 95%CI 1.35, 3.4). Likelihood of taking preventive action was high (mean = 4.15 out of 5). CONCLUSION: Results of this study highlight the need for health system governance to commit to integrate national efforts to design culturally sensitive interventions to raise awareness about the risk of T2DM in Jordan, especially among young adult population. CI - Copyright (c) 2026 Alkhaldi, Taha, BaniMustafa, Al-Shimi, AlSamhori and Alshyyab. FAU - Alkhaldi, Sireen AU - Alkhaldi S AD - Department of Family and Community Medicine, School of Medicine, University of Jordan, Amman, Jordan. FAU - Taha, Hana AU - Taha H AD - Department of Family and Community Medicine, School of Medicine, University of Jordan, Amman, Jordan. FAU - BaniMustafa, Mishkah AU - BaniMustafa M AD - Department of Family and Community Medicine, School of Medicine, University of Jordan, Amman, Jordan. FAU - Al-Shimi, Rana AU - Al-Shimi R AD - School of Medicine, University of Jordan, Amman, Jordan. FAU - AlSamhori, Jehad AU - AlSamhori J AD - School of Medicine, University of Jordan, Amman, Jordan. FAU - Alshyyab, Muhammad AU - Alshyyab M AD - Department of Public Health and Community Medicine, Jordan University of Science and Technology, Irbid, Jordan. LA - eng PT - Journal Article DEP - 20260114 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Jordan/epidemiology MH - *Diabetes Mellitus, Type 2/psychology/epidemiology MH - Male MH - Female MH - Cross-Sectional Studies MH - Young Adult MH - *Health Knowledge, Attitudes, Practice MH - Surveys and Questionnaires MH - *Students/psychology/statistics & numerical data MH - Risk Factors MH - Universities MH - Adult MH - Disease Susceptibility MH - Perception MH - Adolescent PMC - PMC12847315 OTO - NOTNLM OT - Jordan OT - perceived risk OT - susceptibility OT - type 2 diabetes mellitus OT - young adults COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/30 06:29 MHDA- 2026/01/30 06:30 PMCR- 2026/01/14 CRDT- 2026/01/30 04:39 PHST- 2025/10/11 00:00 [received] PHST- 2025/12/16 00:00 [revised] PHST- 2025/12/31 00:00 [accepted] PHST- 2026/01/30 06:30 [medline] PHST- 2026/01/30 06:29 [pubmed] PHST- 2026/01/30 04:39 [entrez] PHST- 2026/01/14 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1722942 [doi] PST - epublish SO - Front Public Health. 2026 Jan 14;13:1722942. doi: 10.3389/fpubh.2025.1722942. eCollection 2025. PMID- 41613058 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - High sugar-sweetened beverage intake predicts adverse physical, emotional, and sleep health trajectories in adolescents: a 4-year prospective cohort study. PG - 1754072 LID - 10.3389/fpubh.2025.1754072 [doi] LID - 1754072 AB - BACKGROUND: Excessive consumption of sugar-sweetened beverages (SSBs) is a major source of added sugars among adolescents and has been associated with adverse cardiometabolic, emotional, and sleep-related outcomes. However, longitudinal evidence from Asian populations remains limited. This 4-year prospective cohort study examined the associations between SSB intake and multiple health trajectories during adolescence. METHODS: A total of 1,204 adolescents (baseline age: 12.41 +/- 0.89 years; 51.2% girls) from 12 secondary schools in Chongqing, China, were followed annually from 2021 to 2024. SSB intake was assessed using a validated food frequency questionnaire adapted for use among Chinese adolescents. Outcomes included body mass index (BMI), body fat percentage, systolic blood pressure, depressive symptoms (CES-D), academic burnout, and sleep quality (Pittsburgh Sleep Quality Index, PSQI). Longitudinal associations were examined using linear mixed-effects models adjusted for age, sex, socioeconomic status, physical activity, screen time, and baseline BMI. RESULTS: Higher SSB intake was associated with significantly steeper increases in BMI (mean increase: +2.87 vs. +1.90 kg/m(2)), body fat percentage (+4.6% vs. +2.1%), systolic blood pressure (+4.8 vs. +2.1 mmHg), depressive symptoms (CES-D: +6.0 vs. +2.0 points), and sleep disturbance (PSQI: +1.3 vs. +0.4 points) compared with the lowest intake tertile (all p < 0.01). Adolescents in the highest SSB tertile exhibited a 62% greater increase in depressive symptoms over 4 years. Participants who reduced SSB intake by >/=30% showed significantly smaller increases across physical, emotional, and sleep-related outcomes. CONCLUSION: High SSB intake is prospectively associated with unfavorable cardiometabolic, emotional, and sleep-related health trajectories during adolescence. Reducing SSB consumption represents a promising and actionable strategy for school-based health promotion and chronic disease prevention among Asian youth. CI - Copyright (c) 2026 Zhang, Li, Zhang and Zhang. FAU - Zhang, Zeyu AU - Zhang Z AD - School of Educational Science, Xinjiang Normal University, Urumqi, China. FAU - Li, Wanjun AU - Li W AD - Biological Education Teaching and Research Group, Chongqing Tongnan Experimental Middle School, Chongqing, China. FAU - Zhang, Min AU - Zhang M AD - English Education Teaching and Research Group, Suqian Chongwen Junior Middle School, Suqian, China. FAU - Zhang, Yike AU - Zhang Y AD - School of Accounting, Nanjing University of Finance and Economics, Nanjing, Jiangsu, China. LA - eng PT - Journal Article DEP - 20260114 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - Prospective Studies MH - *Sugar-Sweetened Beverages/adverse effects/statistics & numerical data MH - Adolescent MH - Male MH - China/epidemiology MH - Child MH - Sleep Quality MH - Body Mass Index MH - Sleep MH - Depression/epidemiology MH - Surveys and Questionnaires PMC - PMC12847052 OTO - NOTNLM OT - adolescent health OT - cardiometabolic risk OT - depressive symptoms OT - longitudinal cohort OT - public health OT - sleep quality OT - sugar-sweetened beverages COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/30 06:29 MHDA- 2026/01/30 06:30 PMCR- 2026/01/14 CRDT- 2026/01/30 04:39 PHST- 2025/11/25 00:00 [received] PHST- 2025/12/21 00:00 [revised] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/01/30 06:30 [medline] PHST- 2026/01/30 06:29 [pubmed] PHST- 2026/01/30 04:39 [entrez] PHST- 2026/01/14 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1754072 [doi] PST - epublish SO - Front Public Health. 2026 Jan 14;13:1754072. doi: 10.3389/fpubh.2025.1754072. eCollection 2025. PMID- 41612839 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260130 LR - 20260813 IS - 2287-9129 (Electronic) IS - 2287-9110 (Print) IS - 2287-9110 (Linking) VI - 32 IP - 1 DP - 2026 Jan TI - Parental and child perspectives on healthy lifestyles and artificial intelligence chatbot use among childhood and adolescent cancer survivors: a descriptive comparative study in South Korea. PG - 27-38 LID - 10.4094/chnr.2025.046 [doi] AB - PURPOSE: This study compared healthy lifestyle (HLS) practices and awareness regarding the use of chatbots (A-uC) for health management between childhood and adolescent cancer survivors (CACSs) and their parents, with the aim of assessing the feasibility of tailored artificial intelligence (AI) chatbot-based interventions for holistic survivorship care. METHODS: A descriptive comparative design was employed involving 80 CACSs and 80 parents (N=160) recruited through the Korean Pediatric Cancer Foundation. HLS practices were assessed using a validated seven-domain instrument encompassing physical activity, nutrition, interpersonal relations, stress management, positive life perspective, health responsibility, and spiritual health. A-uC was evaluated using an extended technology acceptance model-based tool. Responses to the open-ended question addressing unmet HLS practices were analyzed using latent Dirichlet allocation topic modeling. RESULTS: No significant differences were observed between CACSs and parents in overall HLS (CACSs: 3.16+/-0.80; parents: 3.18+/-0.36, p=.74). While perceptions across most A-uC domains did not differ significantly, parents demonstrated a significantly higher "intention to use" chatbots for health management than CACSs (p=.03). The mean A-uC scores exceeded 4 (out of 5) in both groups, reflecting positive perceptions of chatbot-based HLS support. Topic modeling identified "exercise," "healthy diet," and "regular lifestyle" as common unmet areas. CONCLUSION: CACSs and their parents share largely concordant views on HLS and A-uC, with a strong interest in chatbot interventions. These findings underscore the potential of tailored AI chatbot programs to address unmet lifestyle needs and promote holistic survivorship care. FAU - Kang, Kyung-Ah AU - Kang KA AD - Professor, College of Nursing, Sahmyook University, Seoul, Korea. FAU - Kim, Shin-Jeong AU - Kim SJ AD - Professor, Research Institute of Nursing Science, School of Nursing, Hallym University, Chuncheon, Korea. FAU - Song, In-Hye AU - Song IH AD - Researcher, College of Nursing, Sahmyook University, Seoul, Korea. FAU - Yoon, Hee-Jin AU - Yoon HJ AD - Undergraduate Student, College of Nursing, Sahmyook University, Seoul, Korea. LA - eng GR - RS-2025-00523681/National Research Foundation of Korea/ PT - Journal Article DEP - 20260130 PL - Korea (South) TA - Child Health Nurs Res JT - Child health nursing research JID - 101603835 PMC - PMC12933495 OTO - NOTNLM OT - Adolescent OT - Artificial intelligence OT - Cancer survivors OT - Childhood OT - Health COIS- Conflict of interest Kyung-Ah Kang and Shin-Jeong Kim serve on the Editorial Board of this Journal; however, they were not involved in the peer-review process or the publication decision for this manuscript. Aside from this, no further potential conflicts of interest exist. EDAT- 2026/01/30 06:29 MHDA- 2026/01/30 06:30 PMCR- 2026/01/01 CRDT- 2026/01/30 02:58 PHST- 2025/10/31 00:00 [received] PHST- 2026/01/07 00:00 [accepted] PHST- 2026/01/30 06:30 [medline] PHST- 2026/01/30 06:29 [pubmed] PHST- 2026/01/30 02:58 [entrez] PHST- 2026/01/01 00:00 [pmc-release] AID - chnr.2025.046 [pii] AID - chnr-2025-046 [pii] AID - 10.4094/chnr.2025.046 [doi] PST - ppublish SO - Child Health Nurs Res. 2026 Jan;32(1):27-38. doi: 10.4094/chnr.2025.046. Epub 2026 Jan 30. PMID- 41612747 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 1619-3997 (Electronic) IS - 0300-5577 (Linking) VI - 54 IP - 4 DP - 2026 May 26 TI - Reference values for heart rate frequency and variability in premature neonates during the first week of life. PG - 778-787 LID - 10.1515/jpm-2025-0439 [doi] AB - OBJECTIVES: This study aimed to establish reference values for heart rate frequency and variability indices in preterm neonates admitted to a neonatal intensive care unit of a tertiary care hospital during their first week of life. METHODS: In this retrospective cohort study, the Generalized Additive Models for Location Scale and Shape framework was employed to establish reference values for heart rate indices across time-domain, frequency-domain and nonlinear-domain in neonates considering gestational age, postnatal age, sex and birth weight. RESULTS: Heart rate tracings of 594 neonates (45 % female; median gestational age at birth 29(0) (IQR 26(6)-30(5)); 38 % birth weight p90) were analyzed. Reference values were established for 25 heart rate indices. Nearly all heart rate indices were significantly influenced by gestational age, postnatal age and sex. Baseline heart rate decreased with gestational age, increased with postnatal age and was higher in females. Heart rate standard deviation increased with gestational age and postnatal age and was lower in female. Inclusion of birth weight significantly improved model fit for all HRV indices. CONCLUSIONS: This study highlights the importance of considering gestational and postnatal age, sex and birth weight when interpreting neonatal heart rate frequency and variability in preterm neonates. These findings support the need for personalized approaches for neonatal monitoring and interpretation. Future research should validate these values in larger, more diverse populations, including additional clinical factors such as neonatal complications and medication administration, to determine their clinical relevance. CI - (c) 2026 the author(s), published by De Gruyter, Berlin/Boston. FAU - Eenkhoorn, Chantal AU - Eenkhoorn C AUID- ORCID: 0000-0002-0192-2723 AD - Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. FAU - Goos, Tom G AU - Goos TG AD - Department of Neonatal and Pediatrics Intensive Care, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. AD - Department of Biomechanical Engineering, Delft University of Technology, Delft, The Netherlands. FAU - Franx, Arie AU - Franx A AD - Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. FAU - Dankelman, Jenny AU - Dankelman J AD - Department of Biomechanical Engineering, Delft University of Technology, Delft, The Netherlands. FAU - Taal, H Rob AU - Taal HR AD - Department of Neonatal and Pediatrics Intensive Care, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. FAU - Willemsen, Sten P AU - Willemsen SP AD - Department of Biostatistics, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. FAU - Eggink, Alex J AU - Eggink AJ AD - Department of Obstetrics and Gynecology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands. LA - eng PT - Journal Article DEP - 20260202 PL - Germany TA - J Perinat Med JT - Journal of perinatal medicine JID - 0361031 SB - IM MH - Humans MH - Infant, Newborn MH - Female MH - *Heart Rate/physiology MH - Reference Values MH - Retrospective Studies MH - Male MH - Gestational Age MH - *Infant, Premature/physiology MH - Birth Weight MH - Intensive Care Units, Neonatal OTO - NOTNLM OT - GAMLSS OT - neonatal heart rate variability OT - prematurity OT - reference values EDAT- 2026/01/30 06:29 MHDA- 2026/05/08 18:33 CRDT- 2026/01/30 02:03 PHST- 2025/08/12 00:00 [received] PHST- 2026/01/11 00:00 [accepted] PHST- 2026/05/08 18:33 [medline] PHST- 2026/01/30 06:29 [pubmed] PHST- 2026/01/30 02:03 [entrez] AID - jpm-2025-0439 [pii] AID - 10.1515/jpm-2025-0439 [doi] PST - epublish SO - J Perinat Med. 2026 Feb 2;54(4):778-787. doi: 10.1515/jpm-2025-0439. Print 2026 May 26. PMID- 41612434 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260915 IS - 1741-7015 (Electronic) IS - 1741-7015 (Linking) VI - 24 IP - 1 DP - 2026 Jan 29 TI - Dietary patterns and neuropsychological function in adolescents: a cross-sectional and longitudinal study. LID - 10.1186/s12916-026-04658-6 [doi] LID - 118 AB - BACKGROUND: Adolescence is a critical period for brain development, during which dietary patterns may influence neuropsychological functioning. OBJECTIVE: To examine cross-sectional associations and determine if baseline adherence to the Mediterranean diet (MD) and ultra-processed food (UPF) consumption is associated with changes in adolescent neuropsychological outcomes over 6 months. METHODS: This study represents a secondary analysis of the WALNUTs Smart-Snack Trial. We evaluated 653 adolescents (aged 12-16 years) from Barcelona at baseline and at 6-month follow-up. All dietary data used for these analyses were collected at the baseline timepoint only. MD adherence was measured with the KIDMED index and UPF consumption was assessed using a food frequency questionnaire and classified using the NOVA system. Cognitive domains were assessed at both time points using standardised computer-based tasks: attention (alerting, orienting, executive control) with the Attention Network Test; working memory (4-back) with the N-back task; fluid intelligence with the Primary Mental Abilities-Revised; decision-making with the Roulettes Task; and emotion recognition with the Emotion Recognition Task. Behavioural outcomes were also evaluated at both time points using the self-reported Strengths and Difficulties Questionnaire and teacher-reported Attention-Deficit/Hyperactivity Disorder-DSM-IV scales. Associations were examined using multivariable generalised linear models. To further validate UPF consumption estimations, polyphenol biomarkers were measured in urine in a subsample of 257 participants. RESULTS: Greater adherence to the MD was cross-sectionally linked to fewer behavioural problems and higher scores of executive functioning, while higher UPF consumption was associated with poorer emotion recognition, reduced alerting attention, less advantageous decision-making, more behavioural problems and internalising symptoms. Longitudinally, higher UPF consumption was associated with more internalising symptoms and less advantageous decision-making, whereas MD adherence showed no associations. CONCLUSIONS: Greater MD adherence appears associated with more favourable behavioural and cognitive profiles. In contrast, higher UPF consumption seems to be associated with less favourable profiles across multiple neuropsychological domains in adolescents. However, the limited longitudinal evidence points to complex relationships that warrant further investigation. Overall, these findings highlight the importance of promoting healthier dietary habits during adolescence. CI - (c) 2026. The Author(s). FAU - Manidis, Alexios AU - Manidis A AD - Clinical and Epidemiological Neuroscience (NeuroEpia), Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. alexios.manidis@iispv.cat. AD - Department of Nutrition and Dietetics Sciences, School of Health Sciences, Hellenic Mediterranean University, Sitia, Crete, Greece. alexios.manidis@iispv.cat. AD - ISGlobal, Institut de Salut Global de Barcelona-Campus MAR, PRBB, Barcelona, Spain. alexios.manidis@iispv.cat. FAU - Ayala-Aldana, Nicolas AU - Ayala-Aldana N AD - Clinical and Epidemiological Neuroscience (NeuroEpia), Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. AD - ISGlobal, Institut de Salut Global de Barcelona-Campus MAR, PRBB, Barcelona, Spain. AD - Universitat de Barcelona, Barcelona, Spain. FAU - Bernardo-Castro, Sara AU - Bernardo-Castro S AD - Clinical and Epidemiological Neuroscience (NeuroEpia), Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. AD - ISGlobal, Institut de Salut Global de Barcelona-Campus MAR, PRBB, Barcelona, Spain. FAU - Pinar-Marti, Ariadna AU - Pinar-Marti A AD - Clinical and Epidemiological Neuroscience (NeuroEpia), Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. AD - ISGlobal, Institut de Salut Global de Barcelona-Campus MAR, PRBB, Barcelona, Spain. AD - Universitat Pompeu Fabra, Barcelona, Spain. FAU - Galkina, Polina AU - Galkina P AD - Polyphenol Research Group, Departament de Nutricio, Facultat de Farmacia I Ciencies de L'Alimentacio, Ciencies de L'Alimentacio I Gastronomia, Universitat de Barcelona, Barcelona, Spain. AD - Institut de Nutricio I Seguretat Alimentaria (INSA), Universitat de Barcelona (UB), Santa Coloma de Gramanet, 08921, Spain. AD - CIBER Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Madrid, Spain. FAU - Fernandez-Barres, Silvia AU - Fernandez-Barres S AD - Agencia de Salut Publica de Barcelona (ASPB), Placa Lesseps 1, Barcelona, 08023, Spain. FAU - Ramirez-Carrasco, Patricia AU - Ramirez-Carrasco P AD - Polyphenol Research Group, Departament de Nutricio, Facultat de Farmacia I Ciencies de L'Alimentacio, Ciencies de L'Alimentacio I Gastronomia, Universitat de Barcelona, Barcelona, Spain. AD - Institut de Nutricio I Seguretat Alimentaria (INSA), Universitat de Barcelona (UB), Santa Coloma de Gramanet, 08921, Spain. AD - CIBER Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Madrid, Spain. FAU - Lamuela-Raventos, Rosa M AU - Lamuela-Raventos RM AD - Polyphenol Research Group, Departament de Nutricio, Facultat de Farmacia I Ciencies de L'Alimentacio, Ciencies de L'Alimentacio I Gastronomia, Universitat de Barcelona, Barcelona, Spain. AD - Institut de Nutricio I Seguretat Alimentaria (INSA), Universitat de Barcelona (UB), Santa Coloma de Gramanet, 08921, Spain. AD - CIBER Fisiopatologia de La Obesidad y Nutricion (CIBEROBN), Madrid, Spain. FAU - Papandreou, Christopher AU - Papandreou C AD - Clinical and Epidemiological Neuroscience (NeuroEpia), Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. papchris@hmu.gr. AD - Department of Nutrition and Dietetics Sciences, School of Health Sciences, Hellenic Mediterranean University, Sitia, Crete, Greece. papchris@hmu.gr. FAU - Julvez, Jordi AU - Julvez J AD - Clinical and Epidemiological Neuroscience (NeuroEpia), Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. jordi.julvez@iispv.cat. AD - ISGlobal, Institut de Salut Global de Barcelona-Campus MAR, PRBB, Barcelona, Spain. jordi.julvez@iispv.cat. AD - Facultat de Medicina i, Ciencies de La Salut, Human Nutrition Unit , Universitat Rovira I Virgili, Reus, Spain. jordi.julvez@iispv.cat. LA - eng GR - CP14/00108, PI16/00261, PI21/00266/Instituto de Salud Carlos III/ GR - CNS2023-143985/Agencia Estatal de Investigacion/ GR - CNS2023-143985/NextGenerationEU/ PT - Journal Article DEP - 20260129 PL - England TA - BMC Med JT - BMC medicine JID - 101190723 SB - IM MH - Humans MH - Adolescent MH - Cross-Sectional Studies MH - Female MH - Male MH - Child MH - Longitudinal Studies MH - *Diet, Mediterranean MH - *Cognition MH - Neuropsychological Tests MH - Food, Processed MH - Spain MH - *Feeding Behavior PMC - PMC12924547 OTO - NOTNLM OT - Adolescent OT - Cognition OT - Mediterranean diet OT - Neuropsychology OT - Ultra-processed foods COIS- Declarations. Ethics approval and consent to participate: Ethical approval for data collection and analysis for the WSS was granted by the Parc Salut Mar Clinical Research Ethics Committee (approval number: 2015/6026/I). All participants and their legal guardians provided written informed consent at recruitment and follow-up. This investigation is rigorously compliant with the recommendations of the Helsinki Declaration. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/30 06:29 MHDA- 2026/02/21 06:31 PMCR- 2026/01/29 CRDT- 2026/01/30 00:04 PHST- 2025/08/26 00:00 [received] PHST- 2026/01/20 00:00 [accepted] PHST- 2026/02/21 06:31 [medline] PHST- 2026/01/30 06:29 [pubmed] PHST- 2026/01/30 00:04 [entrez] PHST- 2026/01/29 00:00 [pmc-release] AID - 10.1186/s12916-026-04658-6 [pii] AID - 4658 [pii] AID - 10.1186/s12916-026-04658-6 [doi] PST - epublish SO - BMC Med. 2026 Jan 29;24(1):118. doi: 10.1186/s12916-026-04658-6. PMID- 41612366 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260813 IS - 1472-6920 (Electronic) IS - 1472-6920 (Linking) VI - 26 IP - 1 DP - 2026 Jan 29 TI - Computer-based case simulations enhances clinical reasoning skills of non-dental medical students as measured by mini-CEX. LID - 10.1186/s12909-026-08593-1 [doi] LID - 331 AB - PURPOSE: Traditional didactic lecture-based models in stomatology education, which rely on passive learning through lectures and observation, have limitations in fostering clinical reasoning. This study aimed to assess the effectiveness of Computer-based Case Simulations (CCS) in enhancing the clinical reasoning skills of non-dental medical undergraduates, using the Mini-Clinical Evaluation Exercise (Mini-CEX) as an outcome measure. METHODS: The study involved 328 non-dentistry medical undergraduates enrolled in four different educational programs: Bilingual, Pediatrics, Clinical Medicine I and Clinical Medicine II. Both the control and intervention group completed a Mini-CEX prior to training to establish a baseline. The control group received traditional didactic training (lectures + passive clinical observation), while the intervention group underwent CCS. Educational effectiveness was evaluated via theoretical test scores and Mini-CEX assessments. RESULTS: A pre-clerkship survey revealed that non-dentistry undergraduates prioritized learning about various dental diseases and developing clinical diagnostic and therapeutic thinking skills over the technical and procedural skills involved in the delivery of patient care. The intervention group, demonstrated significantly higher theoretical test scores compared with the control group across all classes (Bilingual Class: 98.1 +/- 1.22 vs. 97.3 +/- 0.97, Cohen's d = 1.129; Pediatric Class: 97.9 +/- 0.85 vs. 96.5 +/- 1.35, Cohen's d = 1.072; Clinical Medicine Class Ⅰ: 98.0 +/- 0.91 vs. 97.0 +/- 1.08, Cohen's d = 1.000; Clinical Medicine ClassⅡ: 99.2 +/- 1.04 vs. 97.7 +/- 1.74, Cohen's d = 1.432; all P < 0.05). There was no significant difference in the Mini-CEX score between the groups before the clerkship (P > 0.05). Although both groups showed improvements in Mini-CEX scores post-clerkship, the intervention group exhibited a significantly greater increase (Cohen's d > 0.5, P < 0.01), indicating superior clinical skill development. CONCLUSION: The results suggest that Computer-based case simulations (CCS) were associated with enhanced clinical knowledge and superior development of clinical reasoning skills in non-dentistry medical undergraduates compared to traditional methods, as measured by theoretical examination and Mini-CEX assessment. Future research should explore the long-term retention of clinical reasoning and the feasibility of scaling CCS in resource-limited settings. CI - (c) 2026. The Author(s). FAU - Zeng, Jiahao AU - Zeng J AD - Department of Stomatology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China. FAU - Geng, Yuanming AU - Geng Y AD - Department of Stomatology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China. FAU - Zhang, Jingwen AU - Zhang J AD - Department of Stomatology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China. FAU - Liu, Chundong AU - Liu C AD - Department of Stomatology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China. FAU - Liu, Xin AU - Liu X AD - Department of Stomatology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China. FAU - Shen, Xiaoqing AU - Shen X AD - Department of Stomatology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China. FAU - Lv, Xiaozhi AU - Lv X AD - Department of Stomatology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, 510282, China. FAU - Zhou, Xiaolong AU - Zhou X AD - Department of Orthodontics, School and Hospital of Stomatology, Guangdong Engineering Research Center of Oral Restoration and Reconstruction & Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, Guangzhou Medical University, Guangzhou, Guangdong, 510182, China. 740768956@qq.com. LA - eng PT - Journal Article DEP - 20260129 PL - England TA - BMC Med Educ JT - BMC medical education JID - 101088679 SB - IM MH - Humans MH - *Clinical Competence/standards MH - Educational Measurement MH - *Clinical Reasoning MH - *Computer Simulation MH - Female MH - Male MH - Adult PMC - PMC12930544 OTO - NOTNLM OT - Clinical clerkship OT - Clinical reasoning OT - Computer-based case simulations OT - Critical thinking OT - Dental education OT - Mini-CEX COIS- Declarations. Ethics approval and consent to participate: This is an observational study which has been approved by the Ethics Committee of Zhujiang Hospital, Southern Medical University (2025-KY-004-01). All methods were performed in accordance with relevant guidelines and regulations. All the students participated in research after signing the informed consent. Consent for publication: Not Applicable Competing interests: The authors declare no competing interests. Clinical trial number: Not applicable. EDAT- 2026/01/30 00:54 MHDA- 2026/02/24 06:33 PMCR- 2026/01/29 CRDT- 2026/01/30 00:01 PHST- 2025/01/09 00:00 [received] PHST- 2026/01/06 00:00 [accepted] PHST- 2026/02/24 06:33 [medline] PHST- 2026/01/30 00:54 [pubmed] PHST- 2026/01/30 00:01 [entrez] PHST- 2026/01/29 00:00 [pmc-release] AID - 10.1186/s12909-026-08593-1 [pii] AID - 8593 [pii] AID - 10.1186/s12909-026-08593-1 [doi] PST - epublish SO - BMC Med Educ. 2026 Jan 29;26(1):331. doi: 10.1186/s12909-026-08593-1. PMID- 41612153 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260907 IS - 1532-7795 (Electronic) IS - 1050-8392 (Linking) VI - 36 IP - 1 DP - 2026 Mar TI - The Adolescent Necessities Index: A brief, self-report measure of the material and social conditions necessary for adolescent thriving. PG - e70145 LID - 10.1111/jora.70145 [doi] AB - Healthy development depends on adequate material and social resources, but measures of these affordances are often limited or absent from psychological research. Conventional measures of socioeconomic status, such as household income or parental education, are difficult for adolescents to accurately report and are distal proxies for the resources that directly impact functioning (e.g., nutrition, safety). As a more proximal measure of environmental affordances, we developed the Adolescent Necessities Index (ANI), a 10-item adolescent-report measure. In Study 1, a prospective longitudinal sample of N = 6057 U.S. adolescents, we demonstrate the ANI's convergent, discriminant, and incremental predictive validity for objectively measured report card grades and subjectively reported well-being, as well as measurement invariance across demographic subgroups (e.g., gender, race, and ethnicity). In Study 2, a cross-sectional study in a nationally representative sample of N = 1859 U.S. adolescents, we replicate evidence of incremental predictive validity, demonstrate consensual validity with a parent-report version of the ANI, and establish national norms. The ANI provides a new tool for efficiently capturing adolescents' access to necessities in the modern U.S. CI - (c) 2026 Society for Research on Adolescence. FAU - Jebb, Andrew T AU - Jebb AT AUID- ORCID: 0000-0002-3854-6733 AD - Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. FAU - Brown-Hunt, Maya AU - Brown-Hunt M AD - Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. FAU - Steinberg, Laurence AU - Steinberg L AD - Department of Psychology and Neuroscience, Temple University, Philadelphia, Pennsylvania, USA. FAU - Duckworth, Angela L AU - Duckworth AL AUID- ORCID: 0000-0002-2644-3729 AD - Department of Psychology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. LA - eng GR - 00107377/Walton Family Foundation/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Res Adolesc JT - Journal of research on adolescence : the official journal of the Society for Research on Adolescence JID - 9109126 SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - *Self Report MH - Longitudinal Studies MH - Prospective Studies MH - Cross-Sectional Studies MH - United States MH - Reproducibility of Results MH - Socioeconomic Factors MH - Social Class MH - *Adolescent Development OTO - NOTNLM OT - adolescence OT - needs OT - resources OT - scale OT - well-being EDAT- 2026/01/30 00:55 MHDA- 2026/01/30 06:28 CRDT- 2026/01/29 23:42 PHST- 2025/05/14 00:00 [received] PHST- 2026/01/07 00:00 [accepted] PHST- 2026/01/30 06:28 [medline] PHST- 2026/01/30 00:55 [pubmed] PHST- 2026/01/29 23:42 [entrez] AID - 10.1111/jora.70145 [doi] PST - ppublish SO - J Res Adolesc. 2026 Mar;36(1):e70145. doi: 10.1111/jora.70145. PMID- 41612115 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260813 IS - 1559-0720 (Electronic) IS - 0163-4984 (Print) IS - 0163-4984 (Linking) VI - 204 IP - 7 DP - 2026 Jul TI - Establishment of Thyroid Volume Reference Curves for Children in Xinjiang: An Exploration of Goiter Diagnosis and the Role of Iodine Nutrition. PG - 4844-4854 LID - 10.1007/s12011-026-05000-0 [doi] AB - The validity of applying universal diagnostic standards across diverse populations is a critical public health concern. This study challenges the suitability of China's national thyroid volume (TTV) criteria by establishing region-specific reference curves for 404 children aged 7-13 years in Xinjiang. Our new sex-specific curves, constructed using GAMLSS models, revealed a goiter prevalence of only 1.5%, a stark contrast to the 9.5% in males and 11.7% in females diagnosed using the national standard (McNemar's test, P < 0.001). This discrepancy underscores a significant overestimation by the current national criteria. Furthermore, our analysis elucidated a nuanced role for iodine: while individual iodine indicators (urinary, salivary, and serum) exhibited significant nonlinear associations with TTV, a composite iodine index showed a protective linear negative correlation (P = 0.012). These findings demonstrate that region-specific standards are imperative for accurate goiter diagnosis. They also suggest that in iodine-sufficient populations, the relationship between iodine and thyroid health is a complex physiological modulation rather than a simple risk paradigm. CI - (c) 2026. The Author(s). FAU - Zhou, Jing AU - Zhou J AD - School of Public Health, Xinjiang Medical University, Urumqi, 830017, China. FAU - Wusiman, Kaisaier AU - Wusiman K AD - Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention, Urumqi, 83002, China. AD - Xinjiang Uygur Autonomous Region Academy of Preventive Medicine, Urumqi, 83002, China. FAU - Abuduwaili, Dannier AU - Abuduwaili D AD - Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention, Urumqi, 83002, China. AD - Xinjiang Uygur Autonomous Region Academy of Preventive Medicine, Urumqi, 83002, China. FAU - Yu, Shuai AU - Yu S AD - Laboratory Department, Bortala Mongolian Autonomous Prefecture Center for Disease Control and Prevention, Bole, 833400, China. FAU - Wang, Chenchen AU - Wang C AD - Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention, Urumqi, 83002, China. 357935099@qq.com. AD - Xinjiang Uygur Autonomous Region Academy of Preventive Medicine, Urumqi, 83002, China. 357935099@qq.com. FAU - Wu, Haiyan AU - Wu H AD - Xinjiang Uygur Autonomous Region Center for Disease Control and Prevention, Urumqi, 83002, China. AD - Xinjiang Uygur Autonomous Region Academy of Preventive Medicine, Urumqi, 83002, China. LA - eng GR - 2025D01E47/Outstanding Youth Science Fund of the Natural Science Foundation of Xinjiang Uygur Autonomous Region/ GR - 2025001CXKYXM650022532/Research Project of Xinjiang Uygur Autonomous Region Health Commission/ GR - 82260648/National Natural Science Foundation of China/ GR - TSYC202301B130/Tianshan Talents Program for Training High-Level Talents in Medicine and Healthcare/ PT - Journal Article DEP - 20260129 PL - United States TA - Biol Trace Elem Res JT - Biological trace element research JID - 7911509 RN - 9679TC07X4 (Iodine) SB - IM MH - Humans MH - *Iodine/urine/administration & dosage/blood MH - *Goiter/diagnosis/epidemiology MH - Child MH - China/epidemiology MH - *Thyroid Gland/pathology MH - Female MH - Male MH - Adolescent MH - Reference Values MH - Nutritional Status MH - Organ Size PMC - PMC13319661 OTO - NOTNLM OT - Children OT - Goiter OT - Iodine nutrition OT - Reference values OT - Thyroid volume OT - Xinjiang COIS- Declarations. Ethics Approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Bortala Mongol Autonomous Prefecture Center for Disease Control and Prevention (Approval No.2025-01). Consent to Participate: Written informed consent was obtained from the parents. Competing interests: The authors declare no competing interests. EDAT- 2026/01/30 00:55 MHDA- 2026/06/30 18:42 PMCR- 2026/01/29 CRDT- 2026/01/29 23:33 PHST- 2025/10/24 00:00 [received] PHST- 2026/01/15 00:00 [accepted] PHST- 2026/06/30 18:42 [medline] PHST- 2026/01/30 00:55 [pubmed] PHST- 2026/01/29 23:33 [entrez] PHST- 2026/01/29 00:00 [pmc-release] AID - 10.1007/s12011-026-05000-0 [pii] AID - 5000 [pii] AID - 10.1007/s12011-026-05000-0 [doi] PST - ppublish SO - Biol Trace Elem Res. 2026 Jul;204(7):4844-4854. doi: 10.1007/s12011-026-05000-0. Epub 2026 Jan 29. PMID- 41611458 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 1 DP - 2026 Jan 29 TI - A systematic review of the scope and impact of rural primary healthcare innovations using digital health technology. PG - e097874 LID - 10.1136/bmjopen-2024-097874 [doi] LID - e097874 AB - OBJECTIVES: Digital technology in primary healthcare service delivery can enhance accessibility, service delivery and health outcomes in rural populations. The objective of this systematic review is to review and synthesise the scope and impact of digital health technology innovations within rural primary healthcare settings. DESIGN: Systematic review. DATA SOURCES: Articles published on PubMed, PsycINFO, Cochrane Central, SCOPUS, Web of Science, EMBASE and CINAHL between January 2013 and October 2025 were searched using key search terms. ELIGIBILITY CRITERIA: Patient, intervention, context, outcome model criteria guided article eligibility. Included articles were undertaken in rural populations, used digital health technology for treatment or management, explored the impact of digital health technology on rural primary healthcare and reported on healthcare outcomes. Included articles were in the English language and presented peer-reviewed primary research. DATA EXTRACTION AND SYNTHESIS: Extraction was performed using a bespoke standardised template by multiple reviewers. Quality assessment was undertaken using the Mixed Methods Appraisal Tool. Descriptive analysis and conventional inductive content analysis were applied to quantitative and qualitative data, respectively. The review is written in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols statement guidelines. RESULTS: 66 studies were included in the review. Most studies were conducted in the USA (n=26). Most studies focused on adult patient populations, with limited representation of Indigenous (In=3) and paediatric populations (n=2). Telemedicine/telehealth interventions using audio, video or both were the most common (n=36). Remote patient monitoring or point-of-care testing was integrated into 21 studies. Physical health conditions, particularly diabetes (n=17), cardiovascular diseases (n=11) and general primary healthcare concerns (n=13) were commonly reported. Others reported on areas including mental health, hypertension, obesity and pregnancy care.Conventional inductive content analysis identified key themes: cost and time effectiveness, quality healthcare provision, consumer acceptance from both patients and practitioners, and healthcare service provider perspectives. Uptake barriers included staff workload and patient non-compliance, while facilitators encompassed process standardisation and practitioner acceptance and endorsement. Consumer acceptance was linked to satisfaction, willingness to engage and improved health outcomes and well-being. CONCLUSIONS: Digital health interventions in rural primary healthcare offer significant potential to improve healthcare delivery, reduce costs and enhance patient access, satisfaction and health outcomes. However, careful consideration of factors such as feasibility, consumer and practitioner acceptance, and recognition of limitations is crucial for successful implementation. The review underscores the importance of flexible policies to support emerging digital healthcare solutions, including the integration of artificial intelligence. Overall, digital health interventions offer a promising avenue to improve healthcare outcomes in rural areas and should be prioritised for government funding and investment. PROSPERO REGISTRATION NUMBER: CRD42023477233. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - MacAskill, William AU - MacAskill W AD - Rural Clinical School, School of Medicine and Dentistry, Griffith University, Toowoomba, Queensland, Australia. AD - Rural Medical Education Australia, Toowoomba, Queensland, Australia. FAU - Gill, Pukhraj AU - Gill P AD - Regional Clinical Unit, Medical School, The University of Queensland, Toowoomba, Queensland, Australia. FAU - Woloszczuk, Christina AU - Woloszczuk C AD - Regional Clinical Unit, Medical School, The University of Queensland, Toowoomba, Queensland, Australia. FAU - Alam, Khorshed AU - Alam K AUID- ORCID: 0000-0003-2232-0745 AD - School of Business and Centre for Health Research, University of Southern Queensland, Toowoomba, Queensland, Australia. FAU - Wallis, Katharine AU - Wallis K AD - General Practice Clinical Unit, University of Queensland, Brisbane, Queensland, Australia. FAU - McGrail, Matthew R AU - McGrail MR AUID- ORCID: 0000-0002-6901-8845 AD - Regional Clinical Unit, Medical School, The University of Queensland, Rockhampton, Queensland, Australia. FAU - Kondalsamy-Chennakesavan, Srinivas AU - Kondalsamy-Chennakesavan S AD - Regional Clinical Unit, Medical School, The University of Queensland, Toowoomba, Queensland, Australia. FAU - Nasir, Bushra F AU - Nasir BF AUID- ORCID: 0000-0002-8372-4877 AD - Regional Clinical Unit, Medical School, The University of Queensland, Toowoomba, Queensland, Australia b.nasir@uq.edu.au. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260129 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Primary Health Care MH - Digital Health MH - *Rural Health Services MH - Telemedicine MH - Health Services Accessibility MH - Rural Population MH - *Digital Technology PMC - PMC12863373 OTO - NOTNLM OT - Digital Technology OT - Health Services OT - Primary Health Care COIS- Competing interests: None declared. EDAT- 2026/01/30 00:55 MHDA- 2026/01/30 00:56 PMCR- 2026/01/29 CRDT- 2026/01/29 21:02 PHST- 2026/01/30 00:56 [medline] PHST- 2026/01/30 00:55 [pubmed] PHST- 2026/01/29 21:02 [entrez] PHST- 2026/01/29 00:00 [pmc-release] AID - bmjopen-2024-097874 [pii] AID - 10.1136/bmjopen-2024-097874 [doi] PST - epublish SO - BMJ Open. 2026 Jan 29;16(1):e097874. doi: 10.1136/bmjopen-2024-097874. PMID- 41611454 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 1 DP - 2026 Jan 29 TI - Strengthening active outdoor living among children residing in two disadvantaged neighbourhoods in Copenhagen, Denmark: a mixed methods study protocol for the Happy Healthy Active Children initiative. PG - e107453 LID - 10.1136/bmjopen-2025-107453 [doi] LID - e107453 AB - INTRODUCTION: The Happy Healthy Active Children (HHAC) initiative is a multicomponent community-based initiative aimed at promoting physical activity, food literacy and nature literacy among children in early childhood kindergarten and primary school settings. Developed in collaboration between Activity Experts and Community Stakeholders, HHAC integrates thematic activities (Play, Nature, Food) across kindergartens, schools and the broader community. The initiative responds to growing concerns about declining physical activity levels, insufficient contact with nature and poor dietary habits in childhood, factors known to influence long-term health and well-being. This protocol outlines the design, implementation and planned evaluation of the HHAC initiative. METHODS AND ANALYSIS: HHAC is carried out within the long-term strategic initiative Tingbjerg Changing Diabetes. Following the Supersetting approach, HHAC addresses inequity in health by mobilising resources across local settings (kindergartens, schools and the local community arenas) and population groups (children, parents, staff and other community members) to develop and implement contextually relevant activities promoting outdoor play, cooking and nature experiences. Activities are evaluated using a within-subject design in kindergartens, while in schools a quasi-experimental design with matched control groups is applied. Data is collected at baseline and follow-up through accelerometry, validated questionnaires and structured observations. Primary outcomes include physical activity levels, food literacy and nature literacy. Analyses apply linear mixed-effects models to account for repeated measures and clustering at the institutional level. The evaluation also investigates implementation processes and context-mechanism configurations through a comprehensive realist evaluation. This includes developing a programme theory, conducting interviews with children, parents, staff and other local stakeholders and participant observations aiming to explore experiences and the mechanisms through which the activities contribute to changes in behaviour and well-being. All data will be analysed and condensed for a model for transferability. ETHICS AND DISSEMINATION: Findings will be disseminated through peer-reviewed journals, conference presentations and public engagement activities targeting educators, policymakers and health professionals. The intervention materials will also be made freely available to support broader implementation. The study procedures were registered and approved by The Capital Region's centre for data reviews 'Videnscenter for Dataanmeldelser' (Reference: P-2023-14277). All procedures were carried out under relevant regulations and guidelines. Written information about the study was given to all school principals, teachers and parents/guardians before the start of the study, and written informed consent is obtained from all legal guardians of all participants in their native language prior to child enrolment. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Stougaard, Maria AU - Stougaard M AUID- ORCID: 0000-0002-5573-4971 AD - Steno Diabetes Center Copenhagen, Department of Prevention Health Promotion and Community Care, Herlev, Capital Region of Denmark, Denmark. FAU - Termansen, Tina AU - Termansen T AD - Steno Diabetes Center Copenhagen, Department of Prevention Health Promotion and Community Care, Herlev, Capital Region of Denmark, Denmark tina.termansen@regionh.dk. FAU - Stjernqvist, Nanna Wurr AU - Stjernqvist NW AUID- ORCID: 0009-0002-3854-3329 AD - Steno Diabetes Center Copenhagen, Department of Prevention Health Promotion and Community Care, Herlev, Capital Region of Denmark, Denmark. FAU - Borring, Andrea Skov AU - Borring AS AD - Steno Diabetes Center Copenhagen, Department of Prevention Health Promotion and Community Care, Herlev, Capital Region of Denmark, Denmark. FAU - Villersholt, Niklas Lynge AU - Villersholt NL AD - Steno Diabetes Center Copenhagen, Department of Prevention Health Promotion and Community Care, Herlev, Capital Region of Denmark, Denmark. FAU - Friis, Nadia AU - Friis N AD - Steno Diabetes Center Copenhagen, Department of Prevention Health Promotion and Community Care, Herlev, Capital Region of Denmark, Denmark. FAU - Mullertz, Alberte Laura Oest AU - Mullertz ALO AD - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Capital Region of Denmark, Denmark. FAU - Elsborg, Peter AU - Elsborg P AD - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Frederiksberg, Capital Region of Denmark, Denmark. FAU - Mejsner, Sofie Buch AU - Mejsner SB AD - Steno Diabetes Center Copenhagen, Department of Prevention Health Promotion and Community Care, Herlev, Capital Region of Denmark, Denmark. FAU - Bloch, Paul AU - Bloch P AD - Steno Diabetes Center Copenhagen, Department of Prevention Health Promotion and Community Care, Herlev, Capital Region of Denmark, Denmark. LA - eng PT - Journal Article DEP - 20260129 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Exercise MH - *Health Promotion/methods MH - Denmark MH - Child MH - Research Design MH - Child, Preschool MH - Schools MH - Neighborhood Characteristics MH - Vulnerable Populations MH - Play and Playthings MH - Male MH - Program Evaluation PMC - PMC12887510 OTO - NOTNLM OT - Capacity Building OT - Community-Based Participatory Research OT - Family OT - Health Education OT - Health Equity OT - PUBLIC HEALTH COIS- Competing interests: None declared. EDAT- 2026/01/30 00:54 MHDA- 2026/01/30 00:55 PMCR- 2026/01/29 CRDT- 2026/01/29 21:02 PHST- 2026/01/30 00:55 [medline] PHST- 2026/01/30 00:54 [pubmed] PHST- 2026/01/29 21:02 [entrez] PHST- 2026/01/29 00:00 [pmc-release] AID - bmjopen-2025-107453 [pii] AID - 10.1136/bmjopen-2025-107453 [doi] PST - epublish SO - BMJ Open. 2026 Jan 29;16(1):e107453. doi: 10.1136/bmjopen-2025-107453. PMID- 41611218 OWN - NLM STAT- MEDLINE DCOM- 20260129 LR - 20260930 IS - 2369-1999 (Electronic) IS - 2369-1999 (Linking) VI - 12 DP - 2026 Jan 29 TI - Measurements and Digital Technology Solutions to Monitor Physical Activity in Patients With Pediatric Cancer: Scoping Review. PG - e73889 LID - 10.2196/73889 [doi] LID - e73889 AB - BACKGROUND: Patients with pediatric cancer often experience reduced physical activity (PA) due to treatment-related fatigue, functional limitations, and lack of structured exercise programs. Digital health solutions, including wearable sensors and augmented reality (AR)-based interventions, may offer new possibilities for monitoring and improving PA in this population. OBJECTIVE: This scoping review aims to address existing research gaps by identifying the instruments-both conventional and digital-used to monitor PA in patients with pediatric cancer during treatment. In addition, this study examines PA monitoring methods, identifies the variables collected, and explores the applicability of digital health solutions in facilitating PA engagement among patients with pediatric cancer. METHODS: In accordance with the Joanna Briggs Institute methodology, a systematic search was conducted across 8 scientific databases-ProQuest, Web of Science, EBSCO Complete, Google Scholar, ScienceDirect, Scopus, MEDLINE (PubMed), and Cochrane-on April 18 and 19, 2024. Studies were screened using the Rayyan AI-assisted review tool based on predefined inclusion criteria targeting children aged 7-19 years who were undergoing cancer treatment or were within 2 years posttreatment. Eligible studies included clinical trials and observational studies that examined objective (eg, wearable sensors) and subjective (eg, questionnaires and self-reports) approaches to PA monitoring. Keywords and controlled vocabulary (eg, MeSH [Medical Subject Headings] terms) were identified through a review of relevant literature. Data were extracted systematically to capture study characteristics, intervention types, and outcome measures. Extracted data were charted and synthesized narratively to identify patterns, technological applications, and research gaps in PA monitoring among patients with pediatric cancer. RESULTS: Twelve studies met the inclusion criteria and employed a range of PA monitoring tools. Digital health solutions, including Actical and Garmin VivoFit 3 devices, were used in 5 studies to assess step counts, gait cycles, and movement intensity. Self-reported measures were identified in 11 studies, most commonly the Activities Scale for Kids and the Pediatric Quality of Life Inventory-Multidimensional Fatigue Scale, which provided insights into mobility and fatigue. Despite their feasibility, subjective assessments were limited by recall bias and motivational factors. Although digital health solutions-such as wearable sensors, gamification, and mobile applications-showed potential to improve PA adherence, their application remains underutilized, and evidence regarding their integration in pediatric oncology is limited. CONCLUSIONS: Existing objective and subjective methods for monitoring PA provide valuable insights; however, gaps remain in the use of interactive digital health solutions, such as AR-based interventions, for PA monitoring and engagement. Future research should focus on integrating digital tools that not only track PA but also actively engage patients, enhance motivation, and support rehabilitation across both clinical and home settings. CI - (c)Greta Franceska Jermolenko, Guna Semjonova, Aija Klavina, Evita Dubinina, Keita Augstkalne, Klavs Balamovskis-Kalnins, Alina Cesuna, Emil Syundyukov, Dace Bertule, Madara Blumberga, Ilze Kundzina. Originally published in JMIR Cancer (https://cancer.jmir.org), 29.01.2026. FAU - Jermolenko, Greta Franceska AU - Jermolenko GF AUID- ORCID: 0009-0002-3222-3340 AD - Laboratory of Sports and Nutrition Research, Riga Stradins University, Riga, Latvia. FAU - Semjonova, Guna AU - Semjonova G AUID- ORCID: 0000-0002-6554-0716 AD - Latvian Academy of Sport Education, Riga Stradins University, Riga, Latvia. AD - Department of Rehabilitation, Riga Stradins University, Riga, Latvia. FAU - Klavina, Aija AU - Klavina A AUID- ORCID: 0000-0003-1959-9941 AD - Laboratory of Sports and Nutrition Research, Riga Stradins University, Riga, Latvia. AD - Department of Health Promotion and Rehabilitation, Lithuanian Sports University, Riga, Latvia. AD - Klaipedos Valstybine Kolegija/ Higher Education Institution, Klaipeda, Lithuania. FAU - Dubinina, Evita AU - Dubinina E AUID- ORCID: 0009-0001-0218-9121 AD - Latvian Academy of Sport Education, Riga Stradins University, Riga, Latvia. FAU - Augstkalne, Keita AU - Augstkalne K AUID- ORCID: 0009-0001-2434-2529 AD - Latvian Academy of Sport Education, Riga Stradins University, Riga, Latvia. FAU - Balamovskis-Kalnins, Klavs AU - Balamovskis-Kalnins K AUID- ORCID: 0009-0003-7733-4957 AD - Latvian Academy of Sport Education, Riga Stradins University, Riga, Latvia. FAU - Cesuna, Alina AU - Cesuna A AUID- ORCID: 0009-0004-1454-2190 AD - Faculty of Medicine and Life Sciences, University of Latvia, Riga, Latvia. FAU - Syundyukov, Emil AU - Syundyukov E AUID- ORCID: 0000-0001-7456-7366 AD - Latvian Academy of Sport Education, Riga Stradins University, Riga, Latvia. FAU - Bertule, Dace AU - Bertule D AUID- ORCID: 0000-0002-3074-4188 AD - Department of Rehabilitation, Riga Stradins University, Riga, Latvia. AD - Children's Clinical University Hospital, Riga, Latvia. FAU - Blumberga, Madara AU - Blumberga M AUID- ORCID: 0000-0002-2194-2764 AD - Children's Clinical University Hospital, Riga, Latvia. AD - Medical Education Technology Center, Riga Stradins University, Riga, Latvia. FAU - Kundzina, Ilze AU - Kundzina I AUID- ORCID: 0009-0005-7273-2985 AD - Joint study program Service Design Strategies and Innovation, Art Academy of Latvia, Riga, Latvia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Scoping Review DEP - 20260129 PL - Canada TA - JMIR Cancer JT - JMIR cancer JID - 101666844 SB - IM MH - Humans MH - *Exercise/physiology MH - *Neoplasms/therapy/physiopathology/rehabilitation MH - Child MH - Adolescent MH - Wearable Electronic Devices MH - *Digital Technology/instrumentation/methods MH - Monitoring, Physiologic/methods PMC - PMC12902754 OTO - NOTNLM OT - augmented reality OT - cancer OT - digital health solutions OT - gamification OT - pediatric oncology OT - physical activity monitoring COIS- Conflicts of Interest: None declared. EDAT- 2026/01/30 00:55 MHDA- 2026/01/30 00:56 PMCR- 2026/01/29 CRDT- 2026/01/29 19:53 PHST- 2025/03/13 00:00 [received] PHST- 2025/11/17 00:00 [accepted] PHST- 2025/11/04 00:00 [revised] PHST- 2026/01/30 00:56 [medline] PHST- 2026/01/30 00:55 [pubmed] PHST- 2026/01/29 19:53 [entrez] PHST- 2026/01/29 00:00 [pmc-release] AID - v12i1e73889 [pii] AID - 10.2196/73889 [doi] PST - epublish SO - JMIR Cancer. 2026 Jan 29;12:e73889. doi: 10.2196/73889. PMID- 41610488 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 1532-8449 (Electronic) IS - 0882-5963 (Linking) VI - 87 DP - 2026 Mar-Apr TI - Healthy lifestyle program based on a mobile serious game-extended version for childhood cancer survivors: Development and evaluation of user satisfaction. PG - 286-296 LID - S0882-5963(26)00035-7 [pii] LID - 10.1016/j.pedn.2026.01.024 [doi] AB - PURPOSE: This study aimed to develop a Healthy Lifestyle Program Based on a Mobile Serious Game-Extended version (HLP-MSGe) for childhood cancer survivors (CCSs) and evaluate the satisfaction level of a HLP-MSGe. METHODS: The HLP-MSGe for CCSs included 33 quests with 7 minigames in 7 healthy lifestyle subfactors (health responsibility, physical activity, nutrition, positive life perspective, interpersonal relationships, stress management, and spiritual health). Five experts validated the content, organization, and usability of the HLP-MSGe. A satisfaction survey consisting of 5-point Likert scales was answered by CCSs in South Korea aged 6-14 years old whose cancer treatment was terminated at least 12 months previously. Data were analyzed using means and standard deviations. RESULTS: "Healthy village-Acorn island" was named to an HLP-MSGe-based initial game called "Healthy village-Hope Island". The content validity index score by experts ranged from 0.93 to 1.00, with a mean of 0.95. The mean score of satisfaction with the HLP-MSGe was 4.16 (SD = 0.68) out of 5. CONCLUSION: HLP-MSGe, a mobile serious game, is a health education modality that meets the learning needs of CCSs who recognize games as educational media and is an appropriate educational medium to increase the efficiency and continuity of self-directed health care. IMPLICATIONS FOR PRACTICE: HLP-MSGe for CCSs intervention can contribute to a new paradigmatic approach to healthcare that maximizes the effectiveness of ongoing health self-management of CCSs. It can also be used as a platform to provide health education based on the human holism model, reflecting the multifaceted needs of CCSs including spirituality. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Kang, Kyung-Ah AU - Kang KA AD - College of Nursing, Sahmyook University, Seoul, Republic of Korea. FAU - Song, In-Hye AU - Song IH AD - College of Nursing, Sahmyook University, Seoul, Republic of Korea. Electronic address: songih407@naver.com. FAU - Kim, Han-Ho AU - Kim HH AD - College of Future Convergence, Sahmyook University, Seoul, Republic of Korea. LA - eng PT - Journal Article DEP - 20260128 PL - United States TA - J Pediatr Nurs JT - Journal of pediatric nursing JID - 8607529 SB - IM MH - Humans MH - Child MH - Female MH - Adolescent MH - *Healthy Lifestyle MH - Male MH - *Video Games MH - Republic of Korea MH - *Cancer Survivors/psychology MH - *Health Promotion/methods MH - *Patient Satisfaction MH - Program Evaluation MH - *Neoplasms/therapy MH - Surveys and Questionnaires OTO - NOTNLM OT - Cancer survivors OT - Child OT - Health education OT - Lifestyle health promotion COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/30 00:54 MHDA- 2026/03/26 01:03 CRDT- 2026/01/29 18:04 PHST- 2025/03/27 00:00 [received] PHST- 2026/01/14 00:00 [revised] PHST- 2026/01/15 00:00 [accepted] PHST- 2026/03/26 01:03 [medline] PHST- 2026/01/30 00:54 [pubmed] PHST- 2026/01/29 18:04 [entrez] AID - S0882-5963(26)00035-7 [pii] AID - 10.1016/j.pedn.2026.01.024 [doi] PST - ppublish SO - J Pediatr Nurs. 2026 Mar-Apr;87:286-296. doi: 10.1016/j.pedn.2026.01.024. Epub 2026 Jan 28. PMID- 41610419 OWN - NLM STAT- MEDLINE DCOM- 20260129 LR - 20260827 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Jan 29 TI - A Home-Based Intervention to Improve Adherence to the 24-Hour Movement Guidelines in Young Children: Protocol for a Mobile App-Based Randomized Control Trial. PG - e75621 LID - 10.2196/75621 [doi] LID - e75621 AB - BACKGROUND: One in 10 preschoolers (aged 3-4 y) meet the three 24-hour Movement Guidelines, that is, (1) physical activity, (2) sedentary screen time, and (3) sleep. OBJECTIVE: The overarching aim of this study is to evaluate the effectiveness and feasibility of a 12-week mobile health home-based intervention on 24-hour movement behaviors in preschoolers who meet few guidelines (zero or 1 guideline). METHODS: We will conduct a 12-week randomized controlled trial with a wait-list control in 80 families (40 per arm). Preliminary studies in this population informed intervention app content, features, and app development. Behavior change theories, including transfer theory and the multi-process action control framework, helped inform content presentation and topics. Primary outcomes include device-based and parent-report measures of 24-hour movement behaviors, and the secondary outcome is the feasibility and acceptability of the app. Exploratory outcomes include preschoolers' cognitive and motor skills, changes within the home environment, and behavioral control processes. RESULTS: This 2-phase study (K99/R00) received initial funding in March 2022, and preliminary studies were concluded in December 2023. The main grant received institutional review board approval in April 2024, and the grant funding began in May 2024. The study was registered in Clinical Trials in October 2024 and enrolled its first participant in January 2025. As of October 2025, the study has enrolled 39 families. We anticipate the trial will be completed in late 2026. CONCLUSIONS: This research is designed to test a novel approach to improve all three 24-hour movement behaviors in preschoolers in home settings by using a mobile app. Results from this study will have implications for future 24-hour movement interventions, our understanding of improving all 3 behaviors, and ultimately, improvements in preschoolers' health. TRIAL REGISTRATION: Clinicaltrials.gov NCT06667661; https://clinicaltrials.gov/study/NCT06667661. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/75621. CI - (c)Chelsea L Kracht, Jerica M Berge, Monique LeBlanc, Robert L Newton Jr, Ryan E Rhodes, Grace Bolamperti, Madigan Snodgrass, Leanne M Redman. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 29.01.2026. FAU - Kracht, Chelsea L AU - Kracht CL AUID- ORCID: 0000-0002-5467-0849 AD - Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, United States. FAU - Berge, Jerica M AU - Berge JM AUID- ORCID: 0000-0003-3371-351X AD - Department of Family Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States. FAU - LeBlanc, Monique AU - LeBlanc M AUID- ORCID: 0000-0002-1598-7800 AD - Department of Psychology, Southeastern Louisiana University, Hammond, LA, United States. FAU - Newton, Robert L Jr AU - Newton RL Jr AUID- ORCID: 0000-0002-6863-913X AD - Population and Public Health Division, Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Rhodes, Ryan E AU - Rhodes RE AUID- ORCID: 0000-0003-0940-9040 AD - School of Exercise Science, Physical and Health Education, University of Victoria, Victoria, BC, Canada. FAU - Bolamperti, Grace AU - Bolamperti G AUID- ORCID: 0009-0002-9267-4821 AD - Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, United States. FAU - Snodgrass, Madigan AU - Snodgrass M AUID- ORCID: 0009-0004-0942-9839 AD - Department of Internal Medicine, University of Kansas Medical Center, Kansas City, KS, United States. FAU - Redman, Leanne M AU - Redman LM AUID- ORCID: 0000-0002-7267-7374 AD - Clinical Sciences Division, Pennington Biomedical Research Center, Baton Rouge, LA, United States. LA - eng SI - ClinicalTrials.gov/NCT06667661 GR - K99 HD107158/HD/NICHD NIH HHS/United States GR - L40 HD109931/HD/NICHD NIH HHS/United States GR - R00 HD107158/HD/NICHD NIH HHS/United States GR - P20 GM144269/GM/NIGMS NIH HHS/United States PT - Clinical Trial Protocol PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260129 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - *Mobile Applications MH - Child, Preschool MH - *Exercise MH - Male MH - Female MH - Sleep MH - Sedentary Behavior MH - Randomized Controlled Trials as Topic MH - Screen Time PMC - PMC12902759 OTO - NOTNLM OT - adherence OT - movement behavior OT - physical activity OT - screen time OT - sitting time OT - sleep COIS- Conflicts of Interest: None declared. EDAT- 2026/01/29 19:11 MHDA- 2026/01/29 19:12 PMCR- 2026/01/29 CRDT- 2026/01/29 16:53 PHST- 2025/04/07 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2025/11/24 00:00 [revised] PHST- 2026/01/29 19:12 [medline] PHST- 2026/01/29 19:11 [pubmed] PHST- 2026/01/29 16:53 [entrez] PHST- 2026/01/29 00:00 [pmc-release] AID - v15i1e75621 [pii] AID - 10.2196/75621 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Jan 29;15:e75621. doi: 10.2196/75621. PMID- 41610147 OWN - NLM STAT- MEDLINE DCOM- 20260915 LR - 20260916 IS - 1527-330X (Electronic) IS - 1090-820X (Linking) VI - 46 IP - 10 DP - 2026 Sep 16 TI - Evaluating the Use of 5-Factor Modified Frailty Index to Predict Wound-Healing Complications in Reduction Mammoplasty. PG - NP127-NP132 LID - 10.1093/asj/sjag026 [doi] AB - BACKGROUND: Reduction mammoplasty is an established treatment for symptomatic macromastia. Understanding risk factors associated with complications is essential for counseling and patient selection. The modified frailty index (mFI-5) has been proposed as a simple tool to assess risk in surgical candidates. OBJECTIVES: The authors sought to determine whether the mFI-5 can accurately predict wound-healing complications following reduction mammoplasty. METHODS: A retrospective review was performed of primary bilateral reduction mammoplasty cases between 2017 and 2019 at 1 institution. mFI-5 scores were calculated for each patient. Thirty-day wound-healing complications were defined as incisional dehiscence, T-point breakdown, nipple-areolar complex necrosis, and fat necrosis. Univariate and multivariate logistic regression were used to evaluate predictive value. RESULTS: Four hundred and seventy-four patients were stratified into 3 age groups: 15 to 30, 31 to 50, and >51. Twenty-six percent of patients developed 1 wound-healing problem. On univariate analysis, ages 31 to 50 and 51+ (odds ratio [OR] = 2.75 and 3.16) and mFI score of 1 (OR = 2.07) were associated with an increased risk of wound-healing complications. Adjusted multivariate analysis indicated that age >51 years significantly predicted wound-healing issues (OR = 2.89; P = .001) when controlled for the American Society of Anesthesiologists (ASA) score, smoking, and BMI. The mFI-5 did not significantly predict wound-healing issues when controlled for age, ASA, BMI, or smoking. CONCLUSIONS: In the study population, the mFI-5 was not a statistically significant predictor of wound-healing complications following reduction mammoplasty. When controlling for confounders, advanced age alone seems to place patients at higher risk for wound-healing complications. LEVEL OF EVIDENCE: 3 (THERAPEUTIC): For image description, please refer to the figure legend and surrounding text. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of The Aesthetic Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Lala, Brittany AU - Lala B FAU - Yao, Amy AU - Yao A FAU - Wang, Fei AU - Wang F FAU - Weichman, Katie E AU - Weichman KE LA - eng PT - Journal Article PL - England TA - Aesthet Surg J JT - Aesthetic surgery journal JID - 9707469 RN - Gigantomastia SB - IM MH - Humans MH - Female MH - *Mammaplasty/adverse effects/methods MH - Adult MH - Retrospective Studies MH - Middle Aged MH - *Wound Healing MH - Risk Factors MH - Young Adult MH - *Frailty/diagnosis/complications MH - *Postoperative Complications/etiology/epidemiology/diagnosis MH - Adolescent MH - *Breast/abnormalities/surgery MH - *Hypertrophy/surgery MH - Predictive Value of Tests MH - Risk Assessment/methods MH - Age Factors MH - *Surgical Wound Dehiscence/etiology/epidemiology EDAT- 2026/01/29 19:11 MHDA- 2026/09/15 23:35 CRDT- 2026/01/29 13:42 PHST- 2026/01/15 00:00 [accepted] PHST- 2026/09/15 23:35 [medline] PHST- 2026/01/29 19:11 [pubmed] PHST- 2026/01/29 13:42 [entrez] AID - 8444740 [pii] AID - 10.1093/asj/sjag026 [doi] PST - ppublish SO - Aesthet Surg J. 2026 Sep 16;46(10):NP127-NP132. doi: 10.1093/asj/sjag026. PMID- 41609762 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260918 IS - 1539-2031 (Electronic) IS - 0192-0790 (Linking) VI - 60 IP - 7 DP - 2026 Aug 1 TI - Self-reported Nonceliac Gluten Sensitivity in Patients With Irritable Bowel Syndrome: A Cross-sectional Analysis. PG - 626-633 LID - 10.1097/MCG.0000000000002306 [doi] AB - GOALS: This study investigates the prevalence of self-reported nonceliac gluten sensitivity among individuals fulfilling Rome IV criteria for irritable bowel syndrome in a cohort of young Italian adults. BACKGROUND: Nonceliac gluten sensitivity (NCGS) and irritable bowel syndrome (IBS) share overlapping symptoms, complicating differential diagnosis. While IBS is a functional gastrointestinal disorder, NCGS is characterized by gluten-induced symptoms in individuals without celiac disease or wheat allergy. STUDY: A cross-sectional survey was conducted between January and March 2022 across 13 Italian cities. A validated questionnaire assessed demographics, IBS diagnosis (self-reported or physician-diagnosed), gluten-related symptoms, and adherence to a gluten-free diet (GFD). Participants were categorized as IBS* (self-reported or physician-diagnosed) or no-IBS*, and as IBS*-NCGS* (self-reported or physician-diagnosed) or IBS*-no-NCGS*. Statistical analyses included t tests, Fisher exact test, and ANOVA. RESULTS: Among 5108 valid responses, 819 (16%) met Rome IV criteria for IBS, with 238 (29.1%) also fulfilling NCGS criteria. The prevalence of NCGS was significantly higher in IBS* vs. no-IBS* (29.1% vs. 8.6%, P <0.0001). IBS*-NCGS* individuals more frequently reported extraintestinal symptoms (fatigue, foggy mind, lack of well-being, P <0.02) and neuropsychiatric disorders ( P <0.05). GFD adherence was significantly higher in IBS*-NCGS* than IBS*-no-NCGS* (60.9% vs. 40.5%, P <0.0001). CONCLUSIONS: Nearly 30% of IBS patients also meet NCGS criteria, with distinct extraintestinal features. Identifying IBS patients who may benefit from GFD could improve symptom management and treatment strategies. CI - Copyright (c) 2026 Wolters Kluwer Health, Inc. All rights reserved. FAU - Brindicci, Viviana Fara AU - Brindicci VF AD - Interdisciplinary Department of Medicine, Pediatric Section, University of Bari "Aldo Moro", Children's Hospital "Giovanni XXIII", Bari, Italy. FAU - Cristofori, Fernanda AU - Cristofori F AD - Interdisciplinary Department of Medicine, Pediatric Section, University of Bari "Aldo Moro", Children's Hospital "Giovanni XXIII", Bari, Italy. FAU - Franceschini, Simone AU - Franceschini S AD - Department of Medicine and Aging Sciences, University of Chieti, Chieti, Italy. FAU - Gnasso, Ilaria AU - Gnasso I AD - Pediatric Unit, Department of Medical and Surgical Sciences, University "Magna Graecia" of Catanzaro, Catanzaro, Italy. FAU - Alcini, Paride AU - Alcini P AD - Department of Medicine and Aging Sciences, University of Chieti, Chieti, Italy. FAU - Abondio Tassi, Emanuele AU - Abondio Tassi E AD - Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy. FAU - Santarelli, Lorenzo AU - Santarelli L AD - Department of Medicine and Aging Sciences, University of Chieti, Chieti, Italy. FAU - Dargenio, Vanessa Nadia AU - Dargenio VN AD - Interdisciplinary Department of Medicine, Pediatric Section, University of Bari "Aldo Moro", Children's Hospital "Giovanni XXIII", Bari, Italy. FAU - Castellaneta, Stefania AU - Castellaneta S AD - Interdisciplinary Department of Medicine, Pediatric Section, University of Bari "Aldo Moro", Children's Hospital "Giovanni XXIII", Bari, Italy. FAU - Francavilla, Ruggiero AU - Francavilla R AUID- ORCID: 0000-0002-4603-974 AD - Interdisciplinary Department of Medicine, Pediatric Section, University of Bari "Aldo Moro", Children's Hospital "Giovanni XXIII", Bari, Italy. CN - NCGS study group LA - eng PT - Journal Article PT - Multicenter Study DEP - 20260801 PL - United States TA - J Clin Gastroenterol JT - Journal of clinical gastroenterology JID - 7910017 RN - 8002-80-0 (Glutens) SB - IM MH - Humans MH - *Irritable Bowel Syndrome/diagnosis/epidemiology/diet therapy MH - Cross-Sectional Studies MH - Female MH - Male MH - Italy/epidemiology MH - Diet, Gluten-Free/statistics & numerical data MH - Adult MH - Prevalence MH - Self Report MH - *Glutens/adverse effects/immunology MH - Young Adult MH - Surveys and Questionnaires MH - *Food Hypersensitivity/epidemiology/diagnosis MH - Adolescent OTO - NOTNLM OT - IBS OT - NCGS OT - gluten-free diet OT - gluten-triggered symptoms OT - self-reported prevalence EDAT- 2026/01/29 19:10 MHDA- 2026/06/27 00:51 CRDT- 2026/01/29 12:36 PHST- 2025/06/02 00:00 [received] PHST- 2025/11/17 00:00 [accepted] PHST- 2026/06/27 00:51 [medline] PHST- 2026/01/29 19:10 [pubmed] PHST- 2026/01/29 12:36 [entrez] AID - 00004836-990000000-00596 [pii] AID - 10.1097/MCG.0000000000002306 [doi] PST - epublish SO - J Clin Gastroenterol. 2026 Aug 1;60(7):626-633. doi: 10.1097/MCG.0000000000002306. PMID- 41609190 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 1557-8992 (Electronic) IS - 1044-5463 (Linking) VI - 36 IP - 3 DP - 2026 Apr TI - Sex-Specific Effects of Relative Fat Mass on Attention-Deficit/Hyperactivity Disorder: Insights from the 1999-2004 National Health and Nutrition Examination Survey. PG - 136-143 LID - 10.1177/10445463261416680 [doi] AB - BACKGROUND: Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder in childhood. Conventional adiposity indicators have been linked to ADHD. Relative fat mass (RFM), a novel adiposity measure, has demonstrated advantages in predicting metabolic and cardiovascular disease risk, conditions that share overlapping pathophysiological mechanisms with ADHD. This study aimed to investigate the association between RFM and ADHD, with a particular focus on sex-specific differences. METHODS: Data were obtained from the 1999-2004 National Health and Nutrition Examination Survey, including 5089 children aged 6-14 years. RFM was calculated using height and waist circumference, and ADHD was defined based on physician diagnosis reported in the questionnaire. Multivariable logistic regression models were applied to assess the association between RFM and ADHD. Smooth curve fitting was conducted to validate the results, and subgroup analyses were performed separately for boys and girls. RESULTS: A significant sex-specific association between RFM and ADHD was observed. Among boys, higher RFM levels were inversely associated with ADHD (Model 3: odds ratio [OR] = 0.967, 95% confidence interval [CI]: 0.946-0.989), whereas among girls, higher RFM levels were positively associated with ADHD (Model 3: OR = 1.043, 95% CI: 1.007-1.081). Smooth curve fitting confirmed these opposite linear trends in both sexes. Subgroup analyses further demonstrated that this sex-specific pattern was consistent across strata defined by age, health insurance status, maternal smoking during pregnancy, and birth weight. CONCLUSIONS: There is a significant sex-specific association between RFM and ADHD, showing an inverse relationship in boys and a positive association in girls. These findings suggest that the influence of adiposity distribution on ADHD differs by sex, highlighting the importance of considering sex differences when evaluating risk factors for ADHD. FAU - Bi, Sitong AU - Bi S AD - Department of Children, Beijing Luhe Hospital, Capital Medical University, Beijing, China. FAU - Li, Huijing AU - Li H AD - Department of Children, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing, China. FAU - Xu, Xinyang AU - Xu X AD - Department of Children, Beijing Luhe Hospital, Capital Medical University, Beijing, China. FAU - Li, Lihua AU - Li L AD - Department of Children, Beijing Luhe Hospital, Capital Medical University, Beijing, China. LA - eng PT - Journal Article DEP - 20260129 PL - United States TA - J Child Adolesc Psychopharmacol JT - Journal of child and adolescent psychopharmacology JID - 9105358 SB - IM MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/epidemiology/physiopathology MH - Male MH - Female MH - Child MH - Nutrition Surveys MH - Adolescent MH - *Adiposity/physiology MH - Sex Factors MH - Risk Factors MH - Logistic Models MH - Waist Circumference MH - United States/epidemiology OTO - NOTNLM OT - ADHD OT - NHANES OT - children OT - relative fat mass OT - sex-specific EDAT- 2026/01/29 14:02 MHDA- 2026/04/22 06:34 CRDT- 2026/01/29 07:44 PHST- 2026/04/22 06:34 [medline] PHST- 2026/01/29 14:02 [pubmed] PHST- 2026/01/29 07:44 [entrez] AID - 10.1177/10445463261416680 [doi] PST - ppublish SO - J Child Adolesc Psychopharmacol. 2026 Apr;36(3):136-143. doi: 10.1177/10445463261416680. Epub 2026 Jan 29. PMID- 41609147 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 1759-7390 (Electronic) IS - 1750-8460 (Linking) VI - 87 IP - 1 DP - 2026 Jan 26 TI - Dynamic Changes of De Ritis Ratio in Pediatric Lobar Pneumonia and Their Relationship With Disease Severity. PG - 50389 LID - 10.31083/BJHM50389 [doi] AB - AIMS/BACKGROUND: Lobar pneumonia (LP) remains a significant cause of morbidity in children. Early and accurate assessment of the disease severity is crucial for optimal management, yet readily available and specific biomarkers are lacking. This study aimed to analyze the dynamic changes of aspartate aminotransferase/alanine aminotransferase (De Ritis) ratio in children with LP, and to explore their relationship with the disease severity. METHODS: A total of 120 children with LP admitted to the Affiliated Hospital of Xuzhou Medical University from June 2020 to June 2025 were divided into a common pneumonia group (n = 69) and a severe pneumonia group (n = 51) according to the severity of the disease. Hierarchical multiple linear regression was used to analyze the effects of baseline De Ritis ratio, gender, age, body mass index (BMI) and pulmonary lobe lesions on the DeltaDe Ritis ratio before treatment and 14 days after treatment. Receiver operating characteristic (ROC) curve analysis was performed to assess the diagnostic efficacy of De Ritis ratio in children with LP before treatment. The dose-response relationship between De Ritis ratio and the condition of LP children was analyzed using a restricted cubic spline. The clinical decision curve was used to analyze the diagnostic efficacy of De Ritis ratio in children with LP. RESULTS: Repeated measures analysis of variance showed that the De Ritis ratio had significant time effect, between-group effect and time-group interaction effect (all p < 0.001). The De Ritis ratio of the two groups decreased significantly with treatment, with the decline (DeltaDe Ritis ratio) being significantly higher in the severe pneumonia group than in the common pneumonia group at each time point (p < 0.05). The results of hierarchical multiple linear regression showed that baseline De Ritis ratio (beta < 0), gender, age, BMI and lobar lesions (all beta > 0) had a significant effect on De Ritis ratio (p < 0.05). The area under the curve (AUC) for the De Ritis ratio was 0.908, with an optimal cutoff value of 1.52. The restricted cubic spline analysis revealed a non-linear dose-response relationship between De Ritis ratio and LP (p(nonlinear) < 0.001). According to the clinical decision curve analysis, De Ritis ratio demonstrated substantial clinical utility in the diagnosis of LP. CONCLUSION: De Ritis ratio possesses significant clinical value in the evaluation of LP and its dynamic alterations show a consistent relationship with the severity of the condition. CI - (c) Copyright: (c) 2026 The Author(s). Published by IMR Press. FAU - Li, Rong AU - Li R AD - Department of Pediatrics, The Affiliated Hospital of Xuzhou Medical University, 221000 Xuzhou, Jiangsu, China. FAU - Chen, Shanshan AU - Chen S AD - Department of Pediatrics, The Affiliated Hospital of Xuzhou Medical University, 221000 Xuzhou, Jiangsu, China. FAU - Yang, Qianqian AU - Yang Q AD - Department of Pediatrics, The Affiliated Hospital of Xuzhou Medical University, 221000 Xuzhou, Jiangsu, China. LA - eng PT - Journal Article PL - Singapore TA - Br J Hosp Med (Lond) JT - British journal of hospital medicine (London, England : 2005) JID - 101257109 RN - EC 2.6.1.1 (Aspartate Aminotransferases) RN - EC 2.6.1.2 (Alanine Transaminase) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Male MH - Severity of Illness Index MH - *Aspartate Aminotransferases/blood MH - *Alanine Transaminase/blood MH - Child, Preschool MH - Child MH - Biomarkers/blood MH - *Pneumonia/blood/diagnosis MH - ROC Curve MH - Infant MH - Retrospective Studies OTO - NOTNLM OT - alanine aminotransferase OT - aspartate aminotransferase OT - children OT - disease severity OT - lobar pneumonia EDAT- 2026/01/29 14:02 MHDA- 2026/01/29 14:03 CRDT- 2026/01/29 07:33 PHST- 2025/09/10 00:00 [received] PHST- 2025/11/15 00:00 [revised] PHST- 2025/11/27 00:00 [accepted] PHST- 2026/01/29 14:03 [medline] PHST- 2026/01/29 14:02 [pubmed] PHST- 2026/01/29 07:33 [entrez] AID - S1750-8460(26)00150-0 [pii] AID - 10.31083/BJHM50389 [doi] PST - ppublish SO - Br J Hosp Med (Lond). 2026 Jan 26;87(1):50389. doi: 10.31083/BJHM50389. PMID- 41608104 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260129 LR - 20260131 IS - 1948-9358 (Print) IS - 1948-9358 (Electronic) IS - 1948-9358 (Linking) VI - 17 IP - 1 DP - 2026 Jan 15 TI - Role of fasting glucose and glycated hemoglobin for gestational diabetes mellitus diagnosis: A prospective study. PG - 112882 LID - 10.4239/wjd.v17.i1.112882 [doi] LID - 112882 AB - BACKGROUND: Fasting glucose and glycated hemoglobin (HbA1c) were used to diagnose gestational diabetes during the coronavirus disease 2019 (COVID-19) pandemic. AIM: To determine whether the diagnostic criteria used during the COVID-19 pandemic may play a role outside the pandemic. METHODS: From May 2022 to July 2024, 354 females with an altered 50-g oral glucose tolerance test (OGTT), the usual diagnostic test (100-g OGTT), and the alternative diagnostic (A) criteria (fasting glucose >/= 95 mg/dL and/or HbA1c >/= 5.7%) were tested simultaneously, resulting in four different groups: OGTT+/A+ (n = 20); OGTT+/A- (n = 60); OGTT-/A+ (n = 24); and OGTT-/A- (n = 250). Groups were compared for clinical characteristics and obstetric and perinatal outcomes. RESULTS: Sensitivity of the alternative criteria was 25% and specificity was 91.2%. Body mass index (BMI) was similar from the OGTT-/A+ and OGTT+/A+ groups (30.1 +/- 6.3 kg/m(2) and 32.7 +/- 5.3 kg/m(2), respectively) and significantly higher from the OGTT+/A- and OGTT-/A- groups (26.8 +/- 5.1 kg/m(2) and 25.6 +/- 5.0 kg/m(2), respectively). The between-group differences were similar for the respective rates of large for gestational age (LGA) infants (OGTT+/A+: 38.9%, OGTT+/A-: 11.8%, OGTT-/A+: 29.4%, OGTT-/A-: 12.4%; P = 0.028). In the regression analysis a history of macrosomia [odds ratio (OR) = 7.948, 95% confidence interval (95%CI): 2.269-27.842; P = 0.001] and higher pregestational BMI (OR = 1.069, 95%CI: 1.002-1.140; P = 0.042) independently increased the risk of LGA. CONCLUSION: Despite insufficient validity to replace the OGTT, alternative criteria identify a group of patients with a higher risk profile and adverse perinatal outcomes who could benefit for health interventions. CI - (c)The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. FAU - Molina-Vega, Maria AU - Molina-Vega M AD - Unidad de Gestion Clinica Endocrinologia y Nutricion, Hospital Universitario Virgen de la Victoria, Malaga 29010, Spain. AD - Instituto de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Malaga 29590, Spain. AD - Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y la Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid 28029, Spain. molinavegamaria@gmail.com. FAU - Estebanez-Prieto, Maria J AU - Estebanez-Prieto MJ AD - Unidad de Gestion Clinica Endocrinologia y Nutricion, Hospital Universitario Virgen de la Victoria, Malaga 29010, Spain. FAU - Fernandez-Valero, Andrea AU - Fernandez-Valero A AD - Unidad de Gestion Clinica Endocrinologia y Nutricion, Hospital Universitario Virgen de la Victoria, Malaga 29010, Spain. FAU - Lima-Rubio, Fuensanta AU - Lima-Rubio F AD - Instituto de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Malaga 29590, Spain. FAU - Fernandez-Ramos, Ana M AU - Fernandez-Ramos AM AD - Unidad de Gestion Clinica de Laboratorio, Hospital Universitario Virgen de la Victoria, Malaga 29010, Spain. FAU - Linares-Pineda, Teresa M AU - Linares-Pineda TM AD - Instituto de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Malaga 29590, Spain. FAU - Morcillo, Sonsoles AU - Morcillo S AD - Unidad de Gestion Clinica Endocrinologia y Nutricion, Hospital Universitario Virgen de la Victoria, Malaga 29010, Spain. AD - Instituto de Investigacion Biomedica de Malaga y Plataforma en Nanomedicina-IBIMA Plataforma BIONAND, Malaga 29590, Spain. AD - Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y la Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid 28029, Spain. FAU - Picon-Cesar, Maria J AU - Picon-Cesar MJ AD - Unidad de Gestion Clinica Endocrinologia y Nutricion, Hospital Universitario Virgen de la Victoria, Malaga 29010, Spain. AD - Centro de Investigacion Biomedica en Red de la Fisiopatologia de la Obesidad y la Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid 28029, Spain. LA - eng PT - Journal Article PL - United States TA - World J Diabetes JT - World journal of diabetes JID - 101547524 PMC - PMC12835985 OTO - NOTNLM OT - Diagnostic criteria OT - Fasting blood glucose OT - Gestational diabetes OT - Glycated hemoglobin OT - Large for gestational age COIS- Conflict-of-interest statement: The authors declare that they have no conflicts of interest. EDAT- 2026/01/29 07:34 MHDA- 2026/01/29 07:35 PMCR- 2026/01/15 CRDT- 2026/01/29 04:51 PHST- 2025/08/08 00:00 [received] PHST- 2025/09/04 00:00 [revised] PHST- 2025/11/21 00:00 [accepted] PHST- 2026/01/29 07:35 [medline] PHST- 2026/01/29 07:34 [pubmed] PHST- 2026/01/29 04:51 [entrez] PHST- 2026/01/15 00:00 [pmc-release] AID - 10.4239/wjd.v17.i1.112882 [doi] PST - ppublish SO - World J Diabetes. 2026 Jan 15;17(1):112882. doi: 10.4239/wjd.v17.i1.112882. PMID- 41607465 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 1664-2392 (Print) IS - 1664-2392 (Electronic) IS - 1664-2392 (Linking) VI - 16 DP - 2025 TI - Neutrophil-to-lymphocyte ratio in females as a predictor of embryo acquisition outcomes after IVF/ICSI treatment: a retrospective study. PG - 1705636 LID - 10.3389/fendo.2025.1705636 [doi] LID - 1705636 AB - OBJECTIVE: We aimed to analyze the correlation between the neutrophil-to-lymphocyte ratio (NLR), and the treatment outcomes for infertile women after in vitro fertilization (IVF) using embryo transfer technology. METHODS: This retrospective study enrolled women with infertility at Huzhou Maternal and Child Health Care Hospital who underwent in vitro IVF procedures. Patient data were collected from a reproductive electronic medical record system. We divided 976 participants into positive and negative groups based on embryo availability after IVF. Age, education level, body mass index, infertility type, etiology, miscarriage history, ovarian stimulation protocols, baseline follicle stimulating hormone levels, anti-Mullerian hormone and NLR were compared in both groups. We investigated the association between NLR and IVF outcomes using logistic regression analysis with multi-model adjustments. The receiver operating characteristic (ROC) curve was used to evaluate the screening efficacy of NLR, The subgroup analysis revealed risk variations among different groups. Finally, we performed sensitivity analysis by modifying control values and conducting logistic regression using NLR quartiles. RESULTS: Multimodal adjusted logistic regression analysis revealed a significant association between the second quartile of NLR and negative outcomes of IVF treatment, with an OR value and 95% confidence interval of 0.28 (0.10-0.67). The area under the ROC curve was 0.850 <. We observed an interaction between NLR quartiles and infertility types, particularly positive correlations between primary infertility, female-specific infertility factors, and no history of miscarriage with IVF outcomes at the second quartile. When the second quartile was adjusted as a reference value, the three remaining quartiles exhibited statistically significant differences compared to the second quartile (p for trend = 0.045). CONCLUSION: We recommended dynamically monitoring NLR during the cycle of ovulation induction and advocating individualized inflammatory management based on the cause of infertility to ensure the effectiveness of IVF treatment and prevent resource wastage. CI - Copyright (c) 2026 Shen, Chen, Chen, Jiang, Gu and Lu. FAU - Shen, Liwen AU - Shen L AD - Department of Center for Reproductive Medicine, Huzhou Maternity & Child Health Care Hospital, Huzhou, Zhejiang, China. FAU - Chen, Li AU - Chen L AD - Department of Center for Reproductive Medicine, Huzhou Maternity & Child Health Care Hospital, Huzhou, Zhejiang, China. FAU - Chen, Lifen AU - Chen L AD - Department of Center for Reproductive Medicine, Huzhou Maternity & Child Health Care Hospital, Huzhou, Zhejiang, China. FAU - Jiang, Huiping AU - Jiang H AD - Nursing Department, Huzhou Maternity & Child Health Care Hospital, Huzhou, Zhejiang, China. FAU - Gu, Huifeng AU - Gu H AD - Nursing Department, Huzhou Maternity & Child Health Care Hospital, Huzhou, Zhejiang, China. FAU - Lu, Liqun AU - Lu L AD - Nursing Department, Huzhou Maternity & Child Health Care Hospital, Huzhou, Zhejiang, China. LA - eng PT - Journal Article DEP - 20260113 PL - Switzerland TA - Front Endocrinol (Lausanne) JT - Frontiers in endocrinology JID - 101555782 SB - IM MH - Humans MH - Female MH - Retrospective Studies MH - Adult MH - *Neutrophils/pathology MH - *Fertilization in Vitro/methods MH - *Lymphocytes/pathology MH - Pregnancy MH - *Sperm Injections, Intracytoplasmic/methods MH - *Infertility, Female/therapy/blood MH - *Embryo Transfer MH - Pregnancy Rate MH - ROC Curve MH - Treatment Outcome MH - Prognosis PMC - PMC12834715 OTO - NOTNLM OT - female OT - fertilization in vitro OT - infertility OT - lymphocytes OT - neutrophils COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/29 07:35 MHDA- 2026/01/29 07:36 PMCR- 2026/01/13 CRDT- 2026/01/29 04:44 PHST- 2025/09/15 00:00 [received] PHST- 2025/12/18 00:00 [revised] PHST- 2025/12/19 00:00 [accepted] PHST- 2026/01/29 07:36 [medline] PHST- 2026/01/29 07:35 [pubmed] PHST- 2026/01/29 04:44 [entrez] PHST- 2026/01/13 00:00 [pmc-release] AID - 10.3389/fendo.2025.1705636 [doi] PST - epublish SO - Front Endocrinol (Lausanne). 2026 Jan 13;16:1705636. doi: 10.3389/fendo.2025.1705636. eCollection 2025. PMID- 41606993 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260813 IS - 1600-0412 (Electronic) IS - 0001-6349 (Print) IS - 0001-6349 (Linking) VI - 105 IP - 3 DP - 2026 Mar TI - Differences in prediction of adverse perinatal outcome in term pregnancies by choice of fetal growth reference: A validation study. PG - 466-478 LID - 10.1111/aogs.70136 [doi] AB - INTRODUCTION: Our objectives were to evaluate the association between fetal growth abnormalities and adverse perinatal outcomes in term pregnancies using four different fetal growth references: the recently published Swedish references by Lindstrom et al., the currently used Swedish references by Marsal et al., and the international standards by the WHO and INTERGROWTH-21st (IG21st). The study aimed to evaluate the performance of each reference and determine which reference most accurately identifies small for gestational age (SGA) infants at risk of perinatal mortality and morbidity. MATERIAL AND METHODS: This population-based cohort study included 1 126 059 singleton term births in Sweden from 2010 to 2020. Data were obtained from national registers, including the Swedish Medical Birth Register and the Swedish Neonatal Quality Register. Birthweight centiles were calculated using each growth reference. Adverse perinatal outcomes were categorized by severity and included stillbirth, neonatal death, and serious neonatal morbidity. Logistic regression models were used to assess predictive performance, and sensitivity and false positive rates (FPR) were calculated for SGA thresholds (<3rd and <10th centiles). RESULTS: The distribution of birthweight centiles varied significantly across references. For SGA <3rd centile, the rate ranged from 9.6% for Lindstrom, 2.5% for Marsal, 1.9% for WHO, to 0.7% for IG21st. All references showed similar overall predictive performance (C-index approximately 0.67) but with different discriminatory ability. The predicted risk of perinatal death increased at lower centiles for the Lindstrom reference than for the Marsal and WHO references, and at higher centiles for the IG21st reference. The Lindstrom reference identified the highest proportion of infants as SGA and had the highest sensitivity but also the highest FPR for detecting adverse outcomes. The IG21st reference classified the smallest proportion as SGA, resulting in the lowest sensitivity and FPR. CONCLUSIONS: While all fetal growth references showed comparable predictive ability for adverse perinatal outcomes, they differed substantially in sensitivity and FPR. When the top priority is to identify as many at-risk fetuses as possible, Lindstrom et al.'s reference seems to be the best choice. However, when the top priority is a balanced sensitivity versus FPR, the WHO reference seems most suitable for clinical practice in this population of term births. CI - (c) 2026 The Author(s). Acta Obstetricia et Gynecologica Scandinavica published by John Wiley & Sons Ltd on behalf of Nordic Federation of Societies of Obstetrics and Gynecology (NFOG). FAU - Lindstrom, Linda AU - Lindstrom L AUID- ORCID: 0000-0003-4427-1075 AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. FAU - Ahlsson, Fredrik AU - Ahlsson F AUID- ORCID: 0000-0002-8413-9274 AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. FAU - Axelsson, Ove AU - Axelsson O AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. AD - Centre for Clinical Research Sormland, Uppsala University, Eskilstuna, Sweden. FAU - Granfors, Michaela AU - Granfors M AUID- ORCID: 0000-0002-2925-3779 AD - Division of Clinical Epidemiology, Department of Medicine (Solna), Karolinska Institutet, Stockholm, Sweden. AD - Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden. FAU - Lampa, Erik AU - Lampa E AD - Department of Medical Sciences, Uppsala University, Uppsala, Sweden. FAU - Nelander, Maria AU - Nelander M AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. FAU - Wikstrom, Anna-Karin AU - Wikstrom AK AD - Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. LA - eng GR - LUL-964880/Region Uppsala/ GR - Fodelsefonden/ PT - Journal Article PT - Validation Study DEP - 20260128 PL - United States TA - Acta Obstet Gynecol Scand JT - Acta obstetricia et gynecologica Scandinavica JID - 0370343 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Sweden/epidemiology MH - *Infant, Small for Gestational Age MH - Infant, Newborn MH - *Fetal Development MH - *Pregnancy Outcome MH - Birth Weight MH - *Fetal Growth Retardation/diagnosis MH - Reference Values MH - Adult MH - Predictive Value of Tests MH - Perinatal Mortality MH - Cohort Studies PMC - PMC12942058 OTO - NOTNLM OT - fetal growth retardation OT - growth charts OT - perinatal care OT - perinatal death OT - perinatal mortality OT - pregnancy high-risk OT - pregnancy outcome OT - pregnancy trimester third COIS- None of the authors have a conflict of interest to declare. EDAT- 2026/01/29 07:34 MHDA- 2026/03/06 09:11 PMCR- 2026/01/28 CRDT- 2026/01/29 01:42 PHST- 2025/12/20 00:00 [revised] PHST- 2025/09/17 00:00 [received] PHST- 2025/12/31 00:00 [accepted] PHST- 2026/03/06 09:11 [medline] PHST- 2026/01/29 07:34 [pubmed] PHST- 2026/01/29 01:42 [entrez] PHST- 2026/01/28 00:00 [pmc-release] AID - AOGS70136 [pii] AID - 10.1111/aogs.70136 [doi] PST - ppublish SO - Acta Obstet Gynecol Scand. 2026 Mar;105(3):466-478. doi: 10.1111/aogs.70136. Epub 2026 Jan 28. PMID- 41606948 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260901 IS - 1532-5040 (Electronic) IS - 0959-3985 (Linking) VI - 42 IP - 9 DP - 2026 Sep TI - Operationalizing wellness in physiotherapy: development and validation of a 0-100 wellness physical therapy index from a national population survey. PG - 1171-1180 LID - 10.1080/09593985.2026.2621961 [doi] AB - BACKGROUND: Physiotherapists are increasingly expected to promote physical activity and reduce sedentary time, but there is no simple, field-specific metric that summarizes these behaviors for everyday practice. OBJECTIVE: To develop a 0-100 Wellness Physical Therapy Index (WPTI) combining domain-specific physical activity and sedentary time, and to examine its validity and potential clinical utility in a national sample of adults. METHODS: A cross-sectional secondary analysis of the Sasakawa Sports Foundation "Sports Life Survey 2024 (Adults)" was conducted. Leisure and transport physical activity (min/week) and sedentary time (min/day; reverse-coded) were winsorized and transformed into standardized scores. Principal component analysis generated data-driven weights used to construct the Wellness Physical Therapy Index (WPTI) and rescale it from 0 to 100. Analytic survey weights were constructed using raking with trimming. Distributional properties, internal consistency, convergent validity with total metabolic equivalent (MET) minutes/week, and criterion validity for achieving the World Health Organization (WHO) guideline (>/=600 MET-minutes/week) were evaluated using weighted regression, receiver operating characteristic analyses, and restricted cubic splines. RESULTS: Among 2966 adults with complete data, the mean weighted WPTI score was 20.9 (standard deviation (SD) 11.3). The index showed acceptable internal consistency and moderate correlations with total MET-minutes/week. Higher WPTI scores were strongly associated with meeting the World Health Organization guideline (odds ratio per 10-point increase 19.9, 95% confidence interval 15.7-25.2). Discrimination was excellent (area under the curve 0.865) with good calibration and robust results across sensitivity analyses. CONCLUSIONS: The WPTI provides a practice-ready, physiotherapy-specific index that integrates domain-specific activity and sedentary time into a single 0-100 score. It may support rapid screening, communication about movement and sitting, and the translation of population surveillance data into routine physiotherapy practice. FAU - Kise, Shinyu AU - Kise S AD - Department of Tourism and Health Studies (Sponsored by Ryukyuseimeisaiseikai), Institute for Tourism and Health, Naha, Japan. LA - eng PT - Journal Article PT - Validation Study DEP - 20260128 PL - England TA - Physiother Theory Pract JT - Physiotherapy theory and practice JID - 9015520 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Adult MH - Male MH - Middle Aged MH - *Sedentary Behavior MH - *Physical Therapy Modalities MH - *Exercise MH - Reproducibility of Results MH - *Health Promotion MH - Young Adult MH - Aged MH - Adolescent OTO - NOTNLM OT - Physiotherapy OT - health promotion OT - measurement validation OT - screening OT - sedentary behavior OT - survey weighting EDAT- 2026/01/29 07:34 MHDA- 2026/09/01 05:41 CRDT- 2026/01/29 01:02 PHST- 2026/09/01 05:41 [medline] PHST- 2026/01/29 07:34 [pubmed] PHST- 2026/01/29 01:02 [entrez] AID - 10.1080/09593985.2026.2621961 [doi] PST - ppublish SO - Physiother Theory Pract. 2026 Sep;42(9):1171-1180. doi: 10.1080/09593985.2026.2621961. Epub 2026 Jan 28. PMID- 41606858 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 1873-7145 (Electronic) IS - 0963-9969 (Linking) VI - 221 IP - Pt 1 DP - 2025 Dec TI - Quantitative Peptidomic profiling of caprine and bovine Milk after simulated gastrointestinal digestion: A multidimensional analytical strategy integrating UHPLC-Q-TOF-MS and QqQ-MS. PG - 117264 LID - S0963-9969(25)01602-3 [pii] LID - 10.1016/j.foodres.2025.117264 [doi] AB - Caprine and bovine milk have been widely used as a supplementary nutritional source during early infancy. This study established an integrated peptidomics workflow combining in vitro digestion with multidimensional mass spectrometry (UHPLC-Q-TOF-MS/QqQ-MS) to decode species-specific peptide release patterns. Systemic peptidomic profiling identified 1728 and 1088 unique peptides in caprine and bovine skimmed milk digests, respectively, with beta-casein-derived peptides dominating both systems (CHMP:126 vs BTMP:116). Two beta-casein regions (P90-K112 and M159-L180) were identified as proteolytic hotspots generating structurally diverse peptides. Through relative-to-absolute quantification cascades, ten signature sequences were validated: LYQEPVLGPVR, SDIPNPIGSENSGK, YQEPVLGPVR, INNQFLPYPY, YPVEPFTESQSL, QGPIVLNPW, SLAMAASDISLL, LTEEEK, DMPIQAF, VLVLDTDYK, with species-dependent abundance: YQEPVLGPVR peaked in BTMP (0.84 mg.g(-1)) versus DMPIQAF in CHMP (1.39 mg.g(-1)). These sequence-resolved quantitative maps reveal the species-specific peptide clusters and provided templates for designing hypoallergenic infant formulas or cardiovascular nutraceuticals. This study provided data support for the functional research of dairy products in vivo. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Zhao, Fei AU - Zhao F AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, College of Food Science and Engineering, Ningbo University, Ningbo 315211, China. FAU - Lan, Jing AU - Lan J AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, College of Food Science and Engineering, Ningbo University, Ningbo 315211, China. FAU - Dang, Kuo AU - Dang K AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, College of Food Science and Engineering, Ningbo University, Ningbo 315211, China. FAU - Wang, Yanli AU - Wang Y AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, College of Food Science and Engineering, Ningbo University, Ningbo 315211, China. FAU - Li, Dongbing AU - Li D AD - Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo 315048, Zhejiang, China. FAU - Pan, Daodong AU - Pan D AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, College of Food Science and Engineering, Ningbo University, Ningbo 315211, China. FAU - Du, Lihui AU - Du L AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, College of Food Science and Engineering, Ningbo University, Ningbo 315211, China. FAU - Dang, Yali AU - Dang Y AD - Zhejiang Key Laboratory of Intelligent Food Logistic and Processing, College of Food Science and Engineering, Ningbo University, Ningbo 315211, China. Electronic address: dangyali@nbu.edu.cn. FAU - Gao, Xinchang AU - Gao X AD - Institute of Drug Discovery Technology, Ningbo University, Ningbo, Zhejiang 315211, China; Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo, Zhejiang 315211, China. Electronic address: gaoxinchang@nbu.edu.cn. LA - eng PT - Journal Article DEP - 20250809 PL - Canada TA - Food Res Int JT - Food research international (Ottawa, Ont.) JID - 9210143 RN - 0 (Caseins) RN - 0 (Peptides) SB - IM MH - Animals MH - Cattle MH - *Digestion MH - Goats MH - *Milk/chemistry MH - Caseins/analysis/chemistry/metabolism MH - Chromatography, High Pressure Liquid/methods MH - *Peptides/analysis MH - *Proteomics/methods MH - Tandem Mass Spectrometry/methods MH - Proteolysis MH - Liquid Chromatography-Mass Spectrometry/methods MH - *Gastrointestinal Tract/metabolism OTO - NOTNLM OT - Peptide quantification OT - Protein traceability OT - Simulated in vitro digestion COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/29 07:34 MHDA- 2026/01/29 07:35 CRDT- 2026/01/29 01:00 PHST- 2025/04/21 00:00 [received] PHST- 2025/07/04 00:00 [revised] PHST- 2025/08/06 00:00 [accepted] PHST- 2026/01/29 07:35 [medline] PHST- 2026/01/29 07:34 [pubmed] PHST- 2026/01/29 01:00 [entrez] AID - S0963-9969(25)01602-3 [pii] AID - 10.1016/j.foodres.2025.117264 [doi] PST - ppublish SO - Food Res Int. 2025 Dec;221(Pt 1):117264. doi: 10.1016/j.foodres.2025.117264. Epub 2025 Aug 9. PMID- 41606378 OWN - NLM STAT- MEDLINE DCOM- 20261016 LR - 20261027 IS - 1530-0447 (Electronic) IS - 0031-3998 (Linking) VI - 100 IP - 3 DP - 2026 Aug TI - Using Special Supplemental Nutrition Program for Women, Infants and Children infant food packages as a proxy for breastfeeding status and duration. PG - 1152-1157 LID - 10.1038/s41390-026-04787-x [doi] AB - BACKGROUND: The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) infant food packages contain up to 13,071 mL/month of infant formula for infants ages /=2 NT-proBNP measurements (2003-2023). Temporal change in NT-proBNP was calculated as relative change from baseline levels (relative ∆_NT-proBNP). RESULTS: We studied 4307 patients (derivation cohort [n = 2154, 50%] and validation cohort [n = 2153, 50%]). In the derivation cohort, baseline and follow-up NT-proBNP levels were 189 (77, 538) pg/mL and 285 (127, 852) pg/mL, and 1481 (69%) had temporal increase in NT-proBNP levels (relative ∆_NT-proBNP >0). Higher baseline NT-proBNP levels correlated with older age, atrial fibrillation, hepatorenal dysfunction, biventricular systolic dysfunction, and elevated biventricular filling pressures. Higher baseline NT-proBNP levels and temporal increase in NT-proBNP levels were associated with mortality, and serial NT-proBNP levels had superior prognostic value compared to single (baseline) NT-proBNP measurements. The prognostic performance of NT proBNP was comparable to cardiac catheterization and exercise test indices, both in the derivation and validation cohorts. CONCLUSIONS: NT-proBNP assay is inexpensive, readily available, and noninvasive, making it ideal for longitudinal monitoring. Further studies are required to determine whether interventions that modify the correlates of NT-proBNP level would improve clinical outcomes in this population. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Ellabbad, Mohamed AU - Ellabbad M AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. FAU - Kholeif, Zeyad AU - Kholeif Z AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. FAU - Miranda, William R AU - Miranda WR AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. FAU - Reddy, Yogesh V N AU - Reddy YVN AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. FAU - Connolly, Heidi M AU - Connolly HM AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. FAU - Jaffe, Allan S AU - Jaffe AS AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. FAU - Egbe, Alexander C AU - Egbe AC AD - Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN. Electronic address: egbe.alexander@mayo.edu. LA - eng PT - Journal Article PT - Validation Study DEP - 20260126 PL - United States TA - Am Heart J JT - American heart journal JID - 0370465 RN - 0 (pro-brain natriuretic peptide (1-76)) RN - 0 (Peptide Fragments) RN - 114471-18-0 (Natriuretic Peptide, Brain) RN - 0 (Biomarkers) SB - IM MH - Retrospective Studies MH - Risk Assessment/methods/statistics & numerical data MH - *Heart Defects, Congenital/blood/complications/diagnosis/mortality MH - Prognosis MH - Follow-Up Studies MH - *Peptide Fragments/blood MH - *Natriuretic Peptide, Brain/blood MH - Atrial Fibrillation/blood/epidemiology/etiology MH - Ventricular Dysfunction/blood/epidemiology/etiology MH - Biomarkers/blood MH - Cardiac Catheterization/statistics & numerical data MH - Exercise Test/statistics & numerical data MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged EDAT- 2026/01/29 01:49 MHDA- 2026/03/07 01:37 CRDT- 2026/01/28 19:11 PHST- 2025/11/26 00:00 [received] PHST- 2026/01/22 00:00 [revised] PHST- 2026/01/24 00:00 [accepted] PHST- 2026/03/07 01:37 [medline] PHST- 2026/01/29 01:49 [pubmed] PHST- 2026/01/28 19:11 [entrez] AID - S0002-8703(26)00022-0 [pii] AID - 10.1016/j.ahj.2026.107360 [doi] PST - ppublish SO - Am Heart J. 2026 May;295:107360. doi: 10.1016/j.ahj.2026.107360. Epub 2026 Jan 26. PMID- 41605302 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 1090-2139 (Electronic) IS - 0889-1591 (Linking) VI - 134 DP - 2026 May TI - Lymphocyte-based inflammatory biomarkers during the postpartum period and postpartum depression symptoms in U.S. women. PG - 106466 LID - S0889-1591(26)00214-X [pii] LID - 10.1016/j.bbi.2026.106466 [doi] AB - BACKGROUND: Postpartum depression (PPD) has multiple cascading negative effects on maternal and infant health. Inflammation is a potential factor for the development of PPD. However, lymphocyte-based inflammatory biomarkers, including platelet-to-lymphocyte ratio (PLR), neutrophil-lymphocyte ratio (NLR) and monocyte-lymphocyte ratio (MLR), and PPD remains understudied, especially in U.S. women. METHODS: We conducted a cross-sectional study based on the National Health and Nutrition Examination Survey (NHANES) from 2007 to 2020 pre-pandemic data. Based on demographics and reproductive questionnaires, two strategies were employed to include eligible postpartum women. PPD symptoms were assessed using the PHQ-9 questionnaire. Weighted logistic regression models, restricted cubic spline (RCS) models, eXtreme Gradient Boosting (XGBoost) machine learning (ML) model, subgroup analysis and sensitivity analyses were performed to analyze the relationships between these biomarkers and PPD symptoms. RESULTS: A total of 1,361 postpartum women within the 3-year postpartum period based on strategy 1, and 762 women ranges from one to twenty-eight months postpartum based on strategy 2 were included in analyses. After adjusted for all covariates, PLR during the postpartum period was significantly associated with the reduced risk of PPD symptoms based on both strategies (OR = 0.49, 95% CI: 0.26-0.94, P = 0.033; OR = 0.30, 95% CI: 0.15-0.60, P < 0.001). There was a non-linear relationship between PLR and the risk of PPD symptoms (P-non-linear = 0.011, P-non-linear = 0.001). ML revealed PLR as one important variable for PPD symptoms. Interestingly, postpartum time modified the association between PLR and PPD symptoms (P for interaction = 0.026). The association was significant in women within 12 months postpartum (OR = 0.23, 95% CI: 0.11-0.49, P < 0.001) but not in women with beyond 12 months postpartum. Sensitivity analyses validated the robustness of our findings. CONCLUSIONS: PLR during the postpartum period is an independent risk factor for PPD symptoms in U.S. women, exhibiting its potential as a novel marker for PPD symptoms. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Xie, Kaipeng AU - Xie K AD - Department of Public Health, Women's Hospital of Nanjing Medical University, Nanjing Women and Children's Healthcare Hospital, Nanjing, China. Electronic address: kaipengxie@njmu.edu.cn. LA - eng PT - Journal Article DEP - 20260126 PL - Netherlands TA - Brain Behav Immun JT - Brain, behavior, and immunity JID - 8800478 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - *Depression, Postpartum/blood/immunology/diagnosis MH - Biomarkers/blood MH - Cross-Sectional Studies MH - *Postpartum Period/blood MH - United States MH - *Lymphocytes MH - Inflammation/blood MH - Adult MH - Nutrition Surveys MH - Neutrophils OTO - NOTNLM OT - MLR OT - NHANES OT - NLR OT - PLR OT - Postpartum depression OT - Postpartum period COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/29 01:49 MHDA- 2026/04/12 04:37 CRDT- 2026/01/28 19:11 PHST- 2025/07/01 00:00 [received] PHST- 2025/12/22 00:00 [revised] PHST- 2026/01/25 00:00 [accepted] PHST- 2026/04/12 04:37 [medline] PHST- 2026/01/29 01:49 [pubmed] PHST- 2026/01/28 19:11 [entrez] AID - S0889-1591(26)00214-X [pii] AID - 10.1016/j.bbi.2026.106466 [doi] PST - ppublish SO - Brain Behav Immun. 2026 May;134:106466. doi: 10.1016/j.bbi.2026.106466. Epub 2026 Jan 26. PMID- 41604952 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 1875-595X (Electronic) IS - 0020-6539 (Print) IS - 0020-6539 (Linking) VI - 76 IP - 2 DP - 2026 Apr TI - Multi-Task Deep Learning for Sex and Age Estimation from Panoramic Radiographs in a Brazilian Young Population. PG - 109381 LID - S0020-6539(25)08662-9 [pii] LID - 10.1016/j.identj.2025.109381 [doi] LID - 109381 AB - INTRODUCTION AND AIMS: Accurate estimation of age and sex is crucial in forensic and clinical contexts, however conventional methods are subjective and time-consuming. Panoramic radiographs offer valuable data for automated analysis. Therefore, the aim of this study was to present and evaluate a multi-task deep learning framework based on ForensicNet for simultaneous estimation of chronological age and classification of sex using panoramic radiographs of the Brazilian young population aged 5-15 years. METHODS: A total of 2200 high-resolution panoramic radiographs were retrospectively collected, balanced by age and sex. After applying strict inclusion/exclusion criteria, the images were randomly split into training (1320), validation (440), and test (440) sets. A multi-task DL model based on EfficientNet-B3 was implemented with task-specific branches incorporating Convolutional Block Attention Modules (CBAM) to predict age and sex. The model was trained end-to-end using a weighted multi-task loss (alpha = 0.3 for age, beta = 0.7 for sex) and evaluated against five benchmark architectures. Grad-CAM was used for model interpretability. RESULTS: The proposed ForensicNet outperformed all baseline models, achieving the lowest mean absolute error and highest coefficient of determination in age prediction, and highest accuracy and area under the curve in sex classification. Grad-CAM visualisations confirmed the model's focus on anatomically relevant areas. Ablation studies showed that removing CBAM or altering task weights reduced performance. CONCLUSIONS: The proposed ForensicNet-based multi-task deep learning model demonstrated robust performance in both chronological age estimation and sex classification using panoramic radiographs from young Brazilian individuals, supporting its potential forensic and clinical applicability. CLINICAL RELEVANCE: This framework may assist forensic experts and clinicians by providing fast, objective and reproducible estimations of age and sex from routinely acquired panoramic radiographs, potentially improving identification processes in forensic and pediatric contexts. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Oliveira, Matheus L AU - Oliveira ML AD - Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Sao Paulo, Brazil. FAU - Yang, Su AU - Yang S AD - Department of Oral and Maxillofacial Surgery, Houston Methodist Research Institute, Houston, Texas, USA. FAU - Sampaio-Oliveira, Matheus AU - Sampaio-Oliveira M AD - Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Sao Paulo, Brazil. FAU - Freitas, Deborah Queiroz AU - Freitas DQ AD - Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Sao Paulo, Brazil. FAU - Haiter-Neto, Francisco AU - Haiter-Neto F AD - Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas, Piracicaba, Sao Paulo, Brazil. FAU - Lim, Sang Heon AU - Lim SH AD - Interdisciplinary Program in Bioengineering, Seoul National University, Gwanak-gu, Seoul, Republic of Korea. FAU - Han, Jiyong AU - Han J AD - Interdisciplinary Program in Bioengineering, Seoul National University, Gwanak-gu, Seoul, Republic of Korea. FAU - Kim, Sujeong AU - Kim S AD - Interdisciplinary Program in Bioengineering, Seoul National University, Gwanak-gu, Seoul, Republic of Korea. FAU - Kim, Jun-Min AU - Kim JM AD - Department of Electronics and Information Engineering, Hansung University, Seongbuk-gu, Seoul, Republic of Korea. FAU - Yi, Won-Jin AU - Yi WJ AD - Department of Oral and Maxillofacial Radiology and Dental Research Institute, Seoul National University, Jongno-gu, Seoul, Republic of Korea. Electronic address: wjyi@snu.ac.kr. FAU - Heo, Min-Suk AU - Heo MS AD - Department of Oral and Maxillofacial Radiology and Dental Research Institute, Seoul National University, Jongno-gu, Seoul, Republic of Korea. Electronic address: hmslsh@snu.ac.kr. LA - eng PT - Journal Article DEP - 20260127 PL - England TA - Int Dent J JT - International dental journal JID - 0374714 SB - IM EIN - Int Dent J. 2026 Jun;76(3):109504. doi: 10.1016/j.identj.2026.109504. PMID: 41855705 MH - Humans MH - *Radiography, Panoramic/methods MH - *Deep Learning MH - Brazil MH - Child MH - Male MH - Adolescent MH - *Age Determination by Teeth/methods MH - Retrospective Studies MH - Child, Preschool MH - Female PMC - PMC12865573 OTO - NOTNLM OT - Age estimation OT - Forensic dentistry OT - Multi-task deep learning OT - Panoramic radiography OT - Sex estimation COIS- Conflicts of interests None disclosed. EDAT- 2026/01/29 01:47 MHDA- 2026/03/09 07:42 PMCR- 2026/01/27 CRDT- 2026/01/28 18:08 PHST- 2025/10/16 00:00 [received] PHST- 2025/11/18 00:00 [revised] PHST- 2025/12/21 00:00 [accepted] PHST- 2026/03/09 07:42 [medline] PHST- 2026/01/29 01:47 [pubmed] PHST- 2026/01/28 18:08 [entrez] PHST- 2026/01/27 00:00 [pmc-release] AID - S0020-6539(25)08662-9 [pii] AID - 109381 [pii] AID - 10.1016/j.identj.2025.109381 [doi] PST - ppublish SO - Int Dent J. 2026 Apr;76(2):109381. doi: 10.1016/j.identj.2025.109381. Epub 2026 Jan 27. PMID- 41604201 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260708 IS - 2168-6262 (Electronic) IS - 2168-6254 (Linking) VI - 161 IP - 3 DP - 2026 Mar 1 TI - Diagnosis and Treatment of Acute Appendicitis: 2025 Edition of the World Society of Emergency Surgery Jerusalem Guidelines. PG - 283-295 LID - 10.1001/jamasurg.2025.6218 [doi] AB - IMPORTANCE: Acute appendicitis is the most common abdominal surgical emergency worldwide and a leading cause of emergency hospital admissions and operations. Despite its frequency, substantial variability persists in diagnosis and management across patient populations and health care settings. OBJECTIVE: To provide updated, evidence-based recommendations for the diagnosis and treatment of acute appendicitis in adults, children, pregnant women, older patients (aged >/=65 years), immunocompromised individuals, and patients with obesity (body mass index >/=30), developed by the World Society of Emergency Surgery (WSES) using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. EVIDENCE REVIEW: A systematic literature search was performed in MEDLINE, Embase, Scopus, Web of Science, and the Cochrane Library to identify relevant studies published until May 2025. Eligible designs included randomized clinical trials, observational studies, systematic reviews, and meta-analyses. Risk of bias was assessed with design-appropriate tools (RoB-2, ROBINS-I, QUADAS-2). Evidence profiles and evidence-to-decision frameworks were generated for each of 19 key clinical questions. The certainty of evidence was rated as high, moderate, low, or very low. Recommendations were classified as strong or conditional (weak) according to GRADE. FINDINGS: Six key clinical domains were addressed across 19 questions. Thirty-five recommendations were formulated. Key findings include: (1) clinical risk scores and imaging improve diagnostic accuracy and reduce negative appendectomy rates; (2) nonoperative management with antibiotics is safe and effective in selected patients with uncomplicated appendicitis, with recommendations tailored for specific populations; (3) appendectomy for uncomplicated appendicitis may be safely delayed within 24 hours without increased risk of adverse outcomes; (4) laparoscopic appendectomy remains the standard surgical approach; (5) postoperative antibiotic therapy should be limited to short courses (2-3 days) in complicated disease; and (6) follow-up strategies are essential after nonoperative management of complicated appendicitis with abscess to detect neoplasms. CONCLUSIONS AND RELEVANCE: The 2025 WSES Jerusalem Guidelines provide updated, evidence-based recommendations for the diagnosis and treatment of acute appendicitis with the aim to standardize practice, reduce unwarranted variability, and support safe, effective, and patient-centered care across diverse populations and health care systems. Their implementation should be adapted to local resources. FAU - Podda, Mauro AU - Podda M AD - Department of Surgical Science, Emergency Surgery Unit, University of Cagliari, Cagliari, Italy. FAU - Ceresoli, Marco AU - Ceresoli M AD - Fondazione IRCCS San Gerardo dei Tintori di Monza, Department of General and Emergency Surgery, University of Milano Bicocca, Monza, Italy. FAU - De Simone, Belinda AU - De Simone B AD - Department of Minimally Invasive, General and Emergency Surgery, Infermi Hospital, Rimini, Italy. FAU - Fugazzola, Paola AU - Fugazzola P AD - Department of General Surgery I, University of Pavia, IRCCS San Matteo Hospital, Pavia, Italy. FAU - Pata, Francesco AU - Pata F AD - Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende, Italy. FAU - Balla, Andrea AU - Balla A AD - Department of General and Digestive Surgery, University Hospital Virgen Macarena, Seville, Spain. FAU - Gerardi, Chiara AU - Gerardi C AD - Center for Health Regulatory Policies, Istituto di Ricerche Farmacologiche "Mario Negri" IRCCS, Milan, Italy. FAU - Allocati, Eleonora AU - Allocati E AD - Center for Health Regulatory Policies, Istituto di Ricerche Farmacologiche "Mario Negri" IRCCS, Milan, Italy. FAU - Salminen, Paulina AU - Salminen P AD - Department of Digestive Surgery, Turku University Hospital, Turku, Finland. FAU - Coimbra, Raul AU - Coimbra R AD - Department of Comparative Effectiveness and Clinical Outcomes Research Center, CECORC), Riverside University Health System, Moreno Valley, California. FAU - Kelly, Michael AU - Kelly M AD - Department of Surgery, MedAlliance Hospital, Albury, Australia. FAU - Boermeester, Marja AU - Boermeester M AD - Department of Surgery, Amsterdam UMC, Amsterdam, the Netherlands. FAU - Segovia Lohse, Helmut AU - Segovia Lohse H AD - Department of Emergency, Hospital de Clinicas, San Lorenzo, Paraguay. FAU - Tan, Edward AU - Tan E AD - Department of Surgery, Radboud University Medical Center, Nijmegen, the Netherlands. FAU - Pisanu, Adolfo AU - Pisanu A AD - Department of Surgical Science, Emergency Surgery Unit, University of Cagliari, Cagliari, Italy. FAU - Abu-Zidan, Fikri AU - Abu-Zidan F AD - The Research Office, College of Medicine, United Arab Emirates University, Al-Ain, United Arab Emirates. FAU - Flum, David AU - Flum D AD - Department of Surgery, University of Washington, Seattle. FAU - Sakakushev, Boris AU - Sakakushev B AD - First Clinic of General Surgery, UMHAT St George, Plovdiv, Bulgaria. FAU - Ansaloni, Luca AU - Ansaloni L AD - Department of General Surgery I, University of Pavia, IRCCS San Matteo Hospital, Pavia, Italy. FAU - Gomes, Carlos Augusto AU - Gomes CA AD - Department of Surgery, Faculdade de Medicina, Universitario Therezinha de Jesus, Suprema, Juiz de Fora, Brasil. FAU - Talan, David AU - Talan D AD - Department of Emergency Medicine, Ronald Reagan UCLA Medical Center, Los Angeles, California. FAU - Tebala, Giovanni Domenico AU - Tebala GD AD - Department of Digestive and Emergency Surgery, Azienda Ospedaliera Santa Maria, Terni, Italy. FAU - Shelat, Vishal AU - Shelat V AD - Department of General Surgery, Tan Tock Seng Hospital, Singapore. FAU - Bendinelli, Cino AU - Bendinelli C AD - Department of Surgery, John Hunter Hospital, University of Newcastle, Newcastle, Australia. FAU - Balogh, Zsolt AU - Balogh Z AD - Department of Traumatology, John Hunter Hospital, University of Newcastle, Newcastle, Australia. FAU - Mentula, Panu AU - Mentula P AD - Department of Gastrointestinal Surgery, Helsinki University Hospital, Helsinki, Finland. FAU - Di Carlo, Isidoro AU - Di Carlo I AD - Department of Surgical Sciences and Advances Technologies, University of Catania, Cannizzaro Hospital, Catania, Italy. FAU - Kluger, Yoram AU - Kluger Y AD - Department of Surgery, Laniadu Hospital, Ramat Hasharon, Israel. FAU - Tolonen, Matti AU - Tolonen M AD - Department of Emergency Surgery, Helsinki University Hospital, Helsinki, Finland. FAU - Sammalkorpi, Henna AU - Sammalkorpi H AD - Department of Gastrointestinal Surgery, Helsinki University Hospital, Helsinki, Finland. FAU - Damaskos, Dimitrios AU - Damaskos D AD - Department of Surgery, University of Edinburgh, Royal Infirmary Hospital, Edinburgh, United Kingdom. FAU - Biffl, Walter AU - Biffl W AD - Department of Surgery, Scripps Clinic Medical Group, La Jolla, California. FAU - Yang, Baohong AU - Yang B AD - Department of Gastroenterology and Oncology, Weifang People's Hospital, Weifang, China. FAU - Sallinen, Ville AU - Sallinen V AD - Department of Gastroenterological Surgery, Transplantation and Liver Surgery, Helsinki University Hospital, Helsinki, Finland. FAU - Davies, Justin AU - Davies J AD - Cambridge Colorectal Unit, Addenbrooke's Hospital, Cambridge, United Kingdom. FAU - Vallicelli, Carlo AU - Vallicelli C AD - Department of General, Emergency and Trauma Surgery, Maurizio Bufalini Hospital, Cesena, Italy. FAU - Amico, Francesco AU - Amico F AD - Department of Traumatology, John Hunter Hospital, University of Newcastle, Newcastle, Australia. FAU - Augustin, Goran AU - Augustin G AD - Department of Surgery, University Hospital Centre Zagreb, Zagreb, Croatia. FAU - Cucinotta, Eugenio AU - Cucinotta E AD - Department of Surgery, AOU G. Martino, Messina, Italy. FAU - Litvin, Andrey AU - Litvin A AD - Department of Surgical Diseases 3, Gomel State Medical University, University Clinic, Gomel, Belarus. FAU - Kirkpatrick, Andrew AU - Kirkpatrick A AD - Department of Critical Care Medicine, Foothills Medical Centre, Calgary, Canada. AD - Department of Surgery, Foothills Medical Centre, Calgary, Canada. FAU - de'Angelis, Nicola AU - de'Angelis N AD - General Surgery Department, Fondazione Poliambulanza, Brescia, Italy. FAU - Weber, Dieter AU - Weber D AD - Department of General Surgery, Royal Perth Hospital, University of Western Australia, Perth, Australia. FAU - Leppaniemi, Ari AU - Leppaniemi A AD - Department of Gastrointestinal Surgery, Helsinki University Hospital, Helsinki, Finland. FAU - Lee, Matthew AU - Lee M AD - Department of Applied Health Sciences, University of Birmingham, Birmingham, United Kingdom. AD - Department of Trauma and Emergency Surgery, University of Birmingham, Birmingham, United Kingdom. FAU - Cabrera Vargas, Luis Felipe AU - Cabrera Vargas LF AD - Department of Surgery, Fundacion Santa Fe de Bogota, Universidad de Los Andes, Bogota, Colombia. FAU - Sartelli, Massimo AU - Sartelli M AD - Department of Surgery, Macerata Hospital, Macerata, Italy. FAU - Coccolini, Federico AU - Coccolini F AD - Department of General, Emergency and Trauma Surgery, University of Pisa, Pisa, Italy. FAU - Di Saverio, Salomone AU - Di Saverio S AD - Department of General Surgery, Madonna del Soccorso Hospital, San Benedetto del Tronto, Italy. FAU - Catena, Fausto AU - Catena F AD - Department of General, Emergency and Trauma Surgery, Maurizio Bufalini Hospital, Cesena, Italy. AD - Department of Medical and Surgical Sciences (DIMEC), Alma Mater Studiorum-University of Bologna, Bologna, Italy. LA - eng PT - Journal Article PT - Practice Guideline PL - United States TA - JAMA Surg JT - JAMA surgery JID - 101589553 SB - IM MH - Humans MH - *Appendicitis/diagnosis/surgery/therapy MH - Appendectomy MH - Female MH - Acute Disease MH - Pregnancy EDAT- 2026/01/28 13:12 MHDA- 2026/03/11 19:00 CRDT- 2026/01/28 11:34 PHST- 2026/03/11 19:00 [medline] PHST- 2026/01/28 13:12 [pubmed] PHST- 2026/01/28 11:34 [entrez] AID - 2844195 [pii] AID - 10.1001/jamasurg.2025.6218 [doi] PST - ppublish SO - JAMA Surg. 2026 Mar 1;161(3):283-295. doi: 10.1001/jamasurg.2025.6218. PMID- 41602892 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260128 LR - 20260131 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 13 DP - 2025 TI - Physiological responses of children with surgically corrected congenital heart disease during high-altitude trekking: an exploratory observational study. PG - 1718577 LID - 10.3389/fped.2025.1718577 [doi] LID - 1718577 AB - BACKGROUND: Children with surgically corrected congenital heart disease (CHD) are often perceived as fragile and discouraged from engaging in physical activity, despite evidence that structured exercise improves functional capacity and quality of life. However, data on their physiological responses to extreme environments, such as high-altitude exposure, remain limited. METHODS: We conducted an exploratory observational study during an Annapurna Base Camp trek (maximum altitude 4,150 m) in February 2024. Children with surgically corrected congenital heart disease and accompanying healthy adults participated in the expedition. Oxygen saturation (SpO(2)), heart rate (HR), and blood pressure (SBP and DBP) were recorded daily at sequential altitudes, and adverse events were monitored. RESULTS: From 1,350 m to 4,150 m, SpO(2) showed a similar pattern of decline in children (-9.8%) and adults (-8.1%). CHD participants showed a pronounced chronotropic response (+17.8 bpm) with modest declines in both SBP (-9.0 mmHg) and DBP (-5.5 mmHg), while adults showed minimal change. These findings suggest effective cardiovascular adjustment under hypobaric hypoxia and with no evidence of maladaptation or altitude-related illness. CONCLUSION: Children with surgically corrected CHD showed preserved oxygenation and well-tolerated hemodynamic responses during high-altitude trekking, underscoring their capacity for physiological adaptation when adequately prepared and supervised. The study highlights the feasibility and safety of structured physical challenges for this population and provides preliminary insight into designing exercise programs that promote confidence and participation. CI - (c) 2026 Choi, Kim and Yoon. FAU - Choi, Kwang Ho AU - Choi KH AD - Department of Thoracic and Cardiovascular Surgery, Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Pusan National University School of Medicine, Yangsan-si, Republic of Korea. FAU - Kim, Woong-Han AU - Kim WH AD - Department of Thoracic and Cardiovascular Surgery, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea. AD - JW LEE Center for Global Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. FAU - Yoon, Ja-Kyoung AU - Yoon JK AD - Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea. LA - eng PT - Journal Article DEP - 20260112 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC12833390 OTO - NOTNLM OT - congenital heart disease OT - exercise capacity OT - high altitude OT - pediatrics OT - physiological adaptation OT - surgical correction COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/28 07:47 MHDA- 2026/01/28 07:48 PMCR- 2026/01/12 CRDT- 2026/01/28 05:04 PHST- 2025/10/04 00:00 [received] PHST- 2025/12/12 00:00 [revised] PHST- 2025/12/15 00:00 [accepted] PHST- 2026/01/28 07:48 [medline] PHST- 2026/01/28 07:47 [pubmed] PHST- 2026/01/28 05:04 [entrez] PHST- 2026/01/12 00:00 [pmc-release] AID - 10.3389/fped.2025.1718577 [doi] PST - epublish SO - Front Pediatr. 2026 Jan 12;13:1718577. doi: 10.3389/fped.2025.1718577. eCollection 2025. PMID- 41602872 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260128 LR - 20260131 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 13 DP - 2025 TI - Reliability of the PREFIT fitness-test battery in Chilean preschoolers. PG - 1654731 LID - 10.3389/fped.2025.1654731 [doi] LID - 1654731 AB - INTRODUCTION: This study explores the test-retest reliability of the FITness in PREschoolers (PREFIT) battery, including cardiorespiratory fitness [20 m shuttle run test (SRT)], upper-body muscle strength (handgrip strength), lower-body explosive strength (standing long jump), speed (4 x 10 m shuttle run), and static balance (one-leg stance), in Chilean preschoolers considering weight status, sex, and age. METHODS: The study included 171 Chilean preschoolers (5.4 +/- 0.7 years). The PREFIT battery was applied using a test-retest design within 7-10 days between evaluations, and weight status was determined using BMI z-scores (ClinicalTrials.gov: NCT04269135). Statistical analyses included test-retest differences, Lin's concordance correlation coefficient, Cohen's effect size (d), standard error of measurement, intraclass correlation coefficient (ICC), and Bland-Altman plots. Analyses were performed using STATA. RESULTS: Among the 171 preschoolers (5.4 +/- 0.7 years), test-retest reliability ranged from excellent to moderate for handgrip strength (ICC = 0.8502; 95% CI: 0.81-0.90), 4 x 10 m shuttle run test (ICC = 0.7696, 95% CI: 0.71-0.84), and PREFIT 20 m SRT (ICC = 0.6656; 95% CI: 0.58-0.74), but was poor for the one-leg stance test (ICC = 0.46; 95% CI: 0.36-0.63). SEM and MDC95 values indicated that changes of 0.85 kg, MDC = 9,502.35 kg (handgrip strength), >/=0.89 s (4 x 10 m shuttle run test), >/=5.33 laps (20 m shuttle run test), and >/=12.43 cm (standing long jump) exceeded measurement error. Reliability was similar across sex, age, and weight-status groups. Bland-Altman analyses showed proportional bias and heteroscedasticity for the 20 m shuttle run test and one-leg stance. At the same time, the remaining tests demonstrated consistent measurement error throughout the performance spectrum. CONCLUSION: The PREFIT battery is appropriate for field application among Chilean preschool children, except for the one-leg stance test, which demonstrated inadequate reliability and proportional bias. Reporting MDC95 enables the interpretation of significant change within educational and intervention contexts. CI - (c) 2026 Soto-Sanchez, Leyton-Dinamarca, Kain, Fernandez-Valero, Castro-Cisterna, Arias-Tellez and Ortega. FAU - Soto-Sanchez, Johana AU - Soto-Sanchez J AD - Biomedicine Center, Laboratory of Physical Activity, Exercise and Health, Faculty of Medicine and Health Sciences, Universidad Mayor, Santiago, Chile. FAU - Leyton-Dinamarca, Barbara AU - Leyton-Dinamarca B AD - Public Nutrition Unit, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile. FAU - Kain, Juliana AU - Kain J AD - Public Nutrition Unit, Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile. FAU - Fernandez-Valero, Paz AU - Fernandez-Valero P AD - Carrera de Entrenador en Actividad Fisica y Deporte, Facultad de Ciencias Humanas, Universidad Bernardo O'Higgins, Santiago, Chile. FAU - Castro-Cisterna, Silvia AU - Castro-Cisterna S AD - Department of Physical Education, Faculty of Education, University of the Americas, Santiago, Chile. FAU - Arias-Tellez, Maria Jose AU - Arias-Tellez MJ AD - Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile. FAU - Ortega, Francisco B AU - Ortega FB AD - Department of Physical Education and Sports, Faculty of Sport Sciences, Sport and Health University Research Institute (iMUDS), University of Granada, and CIBEROBN Physiopathology of Obesity and Nutrition, Granada, Spain. AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. LA - eng SI - ClinicalTrials.gov/NCT04269135 PT - Journal Article DEP - 20260112 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC12833291 OTO - NOTNLM OT - cardiorespiratory fitness OT - childhood obesity OT - children OT - fitness OT - girls-boys OT - muscular fitness OT - physical fitness OT - preschool COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/28 07:48 MHDA- 2026/01/28 07:49 PMCR- 2026/01/12 CRDT- 2026/01/28 05:04 PHST- 2025/06/26 00:00 [received] PHST- 2025/12/10 00:00 [revised] PHST- 2025/12/11 00:00 [accepted] PHST- 2026/01/28 07:49 [medline] PHST- 2026/01/28 07:48 [pubmed] PHST- 2026/01/28 05:04 [entrez] PHST- 2026/01/12 00:00 [pmc-release] AID - 10.3389/fped.2025.1654731 [doi] PST - epublish SO - Front Pediatr. 2026 Jan 12;13:1654731. doi: 10.3389/fped.2025.1654731. eCollection 2025. PMID- 41602002 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Allergy-compatible symptoms among federated swimmers in Portugal: a cross-sectional study using the AQUA(R) questionnaire. PG - 1731628 LID - 10.3389/fpubh.2025.1731628 [doi] LID - 1731628 AB - Swimmers are chronically exposed to water disinfection by-products (commonly from chlorination) and to indoor air conditions that may aggravate allergic and respiratory symptoms. Evidence is robust for elite cohorts, but competitive swimmers outside Olympic settings remain understudied. We conducted a cross-sectional, anonymous online survey among Portuguese competitive swimmers, officially registered with the national federation, aged 16 years or older (April-May 2025). The validated Allergy Questionnaire for Athletes (AQUA((R)); 21 items; positive >/=5 points) screened for allergy-compatible symptoms. Associations with demographics, training exposure, and pool environment were examined using descriptive statistics and bivariate tests (alpha = 0.05); exploratory logistic regression assessed independent predictors. Of 100 respondents, 95 valid questionnaires were analyzed. The prevalence of AQUA-positive screening was 81.1% (n = 77/95). Upper-airway complaints were most frequent (e.g., nasal obstruction 63.2%; rhinorrhea 61.1%), followed by cough 55.8% and ocular pruritus (51.6%). AQUA positivity was higher in women vs. men (88.7% vs. 71.4%, p = 0.036). Younger age (16-25 years) and >/=7 weekly training sessions were also associated with higher positivity (p = 0.011 and p = 0.012, respectively). A temperature gradient was evident (/=7 sessions/week, and pool water temperature >25 degrees C remained independent predictors. Allergy-compatible symptoms were common among competitive swimmers, with environmental and training-related correlations. Findings support routine symptom screening (AQUA) in clubs alongside attention to pool management (temperature, ventilation). Larger studies with clinical confirmation and objective environmental monitoring are warranted. CI - Copyright (c) 2026 Ramos, Neiva and Lourenco. FAU - Ramos, Miguel AU - Ramos M AD - Faculty of Health Sciences, University of Beira Interior, Covilha, Portugal. FAU - Neiva, Henrique P AU - Neiva HP AD - Department of Sport Sciences, University of Beira Interior, Covilha, Portugal. AD - Research Centre in Sport Sciences, Health Sciences and Human Development (CIDESD), Covilha, Portugal. FAU - Lourenco, Olga AU - Lourenco O AD - Faculty of Health Sciences, University of Beira Interior, Covilha, Portugal. AD - Department of Medical Sciences, Faculty of Health Sciences, RISE-Health, University of Beira Interior, Covilha, Portugal. LA - eng PT - Journal Article DEP - 20260112 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - 0 (Disinfectants) SB - IM MH - Humans MH - Portugal/epidemiology MH - Cross-Sectional Studies MH - Female MH - Male MH - Adolescent MH - *Swimming/statistics & numerical data MH - Surveys and Questionnaires MH - Adult MH - *Hypersensitivity/epidemiology MH - Young Adult MH - *Athletes/statistics & numerical data MH - Prevalence MH - Swimming Pools MH - *Disinfectants/adverse effects PMC - PMC12832999 OTO - NOTNLM OT - AQUA questionnaire OT - allergic symptoms OT - asthma OT - athletes OT - chloramines OT - cross-sectional study OT - indoor air quality OT - swimming COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author HN declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2026/01/28 07:47 MHDA- 2026/01/28 19:21 PMCR- 2026/01/12 CRDT- 2026/01/28 04:56 PHST- 2025/12/18 00:00 [received] PHST- 2025/11/21 00:00 [revised] PHST- 2025/12/25 00:00 [accepted] PHST- 2026/01/28 19:21 [medline] PHST- 2026/01/28 07:47 [pubmed] PHST- 2026/01/28 04:56 [entrez] PHST- 2026/01/12 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1731628 [doi] PST - epublish SO - Front Public Health. 2026 Jan 12;13:1731628. doi: 10.3389/fpubh.2025.1731628. eCollection 2025. PMID- 41601900 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260128 LR - 20260131 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Exploring the potential association between dietary factors and autism spectrum disorder: a Mendelian randomization analysis and retrospective study. PG - 1716044 LID - 10.3389/fnut.2025.1716044 [doi] LID - 1716044 AB - BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental condition involving complex genetic and environmental interactions. This study aimed to investigate the causal relationships between dietary factors, ketones, food allergy, and the risk of ASD using Mendelian randomization (MR) and clinical research. METHODS: We used two-sample MR to analyze the causal associations between 199 dietary factors, ketones, food allergy, and ASD risk using genome-wide association study (GWAS) data. Validity was assessed using sensitivity analyses. Additionally, a retrospective study (n = 78, age range 2-7 years) evaluated the clinical effects of a gluten-free casein-free (GFCF) diet on ASD symptoms, as measured by the Childhood Autism Rating Scale (CARS) and the Autism Diagnostic Observation Schedule, Second Edition (ADOS-2). RESULTS: MR analysis identified significant positive causal effects on ASD risk for wholemeal pasta (OR: 16.0, 95% CI 2.86-89.4, p = 0.002) and cheese spread (OR: 9.53, 95% CI 1.64-55.4, p = 0.020). It is crucial to emphasize that these estimates represent the lifetime effect of a genetic predisposition to a higher intake level, not the risk from short-term consumption. The very wide confidence intervals indicate substantial uncertainty in the point estimates. Banana had a protective effect (OR: 0.50, 95% CI: 0.30-0.83, p = 0.008). No causal links were identified for the other factors. Mediation analysis suggested that cheese spread intake increased ASD risk partly by lowering HLA-DR + T cell CD45 levels (10.2% mediation) and increasing anti-Epstein-Barr virus IgG seropositivity (12.9% mediation). Clinically, Although the GFCF diet did not significantly improve ADOS-2 and CARS scores, it showed greater improvement compared to the normal diet group. This diet significantly reduced milk- and wheat-specific IgG levels, indicating its ability to effectively modulate immune responses. CONCLUSION: This study provides genetic evidence of causal relationships between specific dietary factors and ASD risk. Clinical data indicate that adhering to a gluten-free, casein-free diet and avoiding related allergenic foods can effectively modulate food-specific immune responses and may also improve ASD symptoms. These findings contribute to deepening our understanding of ASD etiology and optimizing nutritional treatment protocols. CI - Copyright (c) 2026 Guo, Wang, Zhu, Che, Yu, Cai, Leng, Chen and Cao. FAU - Guo, Yan-Shuo AU - Guo YS AD - Department of Paediatrics, Shandong University Qilu Hospital, Jinan, Shandong, China. FAU - Wang, Yu AU - Wang Y AD - Department of Paediatrics, Shandong University Qilu Hospital, Jinan, Shandong, China. FAU - Zhu, Meng-Na AU - Zhu MN AD - Department of Paediatrics, Shandong University Qilu Hospital, Jinan, Shandong, China. FAU - Che, Chao AU - Che C AD - Department of Paediatrics, Shandong University Qilu Hospital, Jinan, Shandong, China. FAU - Yu, Xiao-Xiao AU - Yu XX AD - Department of Paediatrics, Shandong University Qilu Hospital, Jinan, Shandong, China. FAU - Cai, Zhi-Feng AU - Cai ZF AD - Department of Paediatrics, Shandong University Qilu Hospital, Jinan, Shandong, China. FAU - Leng, Juan AU - Leng J AD - Department of Paediatrics, Shandong University Qilu Hospital, Jinan, Shandong, China. FAU - Chen, Kun-Ping AU - Chen KP AD - Department of Paediatrics, Shandong University Qilu Hospital, Jinan, Shandong, China. FAU - Cao, Ai-Hua AU - Cao AH AD - Department of Paediatrics, Shandong University Qilu Hospital, Jinan, Shandong, China. AD - Department of General Surgery, Qilu Hospital of Shandong University Dezhou Hospital, Dezhou, Shandong, China. LA - eng PT - Journal Article DEP - 20260112 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12832469 OTO - NOTNLM OT - Mendelian randomization OT - autism spectrum disorder OT - dietary factors OT - mediation analysis OT - retrospective study COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/28 07:47 MHDA- 2026/01/28 07:48 PMCR- 2026/01/12 CRDT- 2026/01/28 04:56 PHST- 2025/10/01 00:00 [received] PHST- 2025/11/19 00:00 [revised] PHST- 2025/12/15 00:00 [accepted] PHST- 2026/01/28 07:48 [medline] PHST- 2026/01/28 07:47 [pubmed] PHST- 2026/01/28 04:56 [entrez] PHST- 2026/01/12 00:00 [pmc-release] AID - 10.3389/fnut.2025.1716044 [doi] PST - epublish SO - Front Nutr. 2026 Jan 12;12:1716044. doi: 10.3389/fnut.2025.1716044. eCollection 2025. PMID- 41601261 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260714 IS - 2153-2176 (Electronic) IS - 2153-2168 (Linking) VI - 22 IP - 2 DP - 2026 Mar TI - Psychosocial Outcomes Reported in Randomized Behavioral Intervention Trials for Children and Adolescents with Overweight and Obesity: A Scoping Review. PG - 110-136 LID - 10.1177/21532176251408689 [doi] AB - BACKGROUND: Many children and adolescents with overweight or obesity experience negative psychosocial health consequences. Systematic reviews show that behavioral interventions can help improve specific psychosocial outcomes. This scoping review aims to identify and map the different types of psychosocial outcomes measured and reported in randomized behavioral intervention trials for managing pediatric overweight and obesity. METHODS: A total of 11 databases were searched until February 2024. We included randomized behavioral intervention trials for children and adolescents ( 11,300 people in the UK and is characterized by thick, sticky mucus in the lungs, leading to recurrent infections, inflammation, and progressive respiratory decline. Chest physiotherapy remains a cornerstone of airway clearance; however, many people with CF (pwCF) find it burdensome and time-consuming. Exercise has been proposed as a potentially effective and more acceptable alternative. The ExACT-CF feasibility trial evaluated the use of exercise as an airway clearance technique in pwCF on modulator therapy. METHODS: This nested qualitative study explored the experiences of participants and healthcare professionals involved in the ExACT-CF trial, alongside broader perspectives on airway clearance, to inform future research and clinical practice. Purposively sampled semi-structured interviews were conducted with 32 individuals: ten pwCF, five parents, twelve healthcare professionals, four decliners, and one participant who withdrew. Interviews were audio-recorded, transcribed verbatim, and analyzed thematically using "The Framework Method." RESULTS: Two primary themes emerged. Theme 1 reflected experiences and lessons learned from the trial, including reported barriers and facilitators around recruitment, randomization, and daily implementation. Despite some minor difficulties, trial participation, processes, and the intervention itself were broadly acceptable. Theme 2 highlighted a preference for using ExACT alone or interchangeably with chest physiotherapy. Participants emphasized the need for robust clinical evidence to guide use. ANSWER: This study highlights the acceptability of both the ExACT-CF trial processes and the use of this exercise-based airway clearance technique. Findings support progression to a definitive trial and further exzploration of patient-centered, flexible approaches to airway clearance in CF. TRIAL REGISTRATION: NCT02429180. CI - (c) 2026 The Author(s). Pediatric Pulmonology published by Wiley Periodicals LLC. FAU - Taylor, Emily AU - Taylor E AUID- ORCID: 0009-0004-9541-785X AD - Department of Child Life and Health, University of Edinburgh, Edinburgh, UK. AD - Department of Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children and Young People, Edinburgh, UK. FAU - Soilemezi, Dia AU - Soilemezi D AD - Department of Psychology, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK. FAU - Urquhart, Don S AU - Urquhart DS AUID- ORCID: 0000-0002-9048-9692 AD - Department of Child Life and Health, University of Edinburgh, Edinburgh, UK. AD - Department of Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children and Young People, Edinburgh, UK. FAU - Cunningham, Steve AU - Cunningham S AUID- ORCID: 0000-0001-7342-251X AD - Department of Child Life and Health, University of Edinburgh, Edinburgh, UK. AD - Department of Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children and Young People, Edinburgh, UK. AD - Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK. FAU - Lewis, Steff AU - Lewis S AUID- ORCID: 0000-0003-1210-2314 AD - Usher Institute, Edinburgh Clinical Trials Unit, NINE Edinburgh Bioquarter, University of Edinburgh, Edinburgh, France. FAU - Neilson, Aileen Rae AU - Neilson AR AUID- ORCID: 0000-0003-3758-0566 AD - Usher Institute, Edinburgh Clinical Trials Unit, NINE Edinburgh Bioquarter, University of Edinburgh, Edinburgh, France. FAU - Ensor, Hannah AU - Ensor H AUID- ORCID: 0000-0003-3052-7287 AD - Usher Institute, Edinburgh Clinical Trials Unit, NINE Edinburgh Bioquarter, University of Edinburgh, Edinburgh, France. FAU - Vogiatizis, Ioannis AU - Vogiatizis I AUID- ORCID: 0000-0003-4830-7207 AD - Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK. FAU - Allen, Lorna AU - Allen L AD - Cystic Fibrosis Trust, One Aldgate, Second Floor, London, UK. FAU - Saynor, Zoe L AU - Saynor ZL AUID- ORCID: 0000-0003-0674-8477 AD - School of Health Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK. AD - Wessex Cystic Fibrosis Unit, University Hospitals Southampton NHS Foundation Trust, Southampton, UK. AD - National Institute for Health and Care Research, Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK. CN - ExACT-CF study group LA - eng SI - ClinicalTrials.gov/NCT02429180 GR - NIHR203185/National Institute for Health and Care Research/ PT - Clinical Trial, Phase I PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Pediatr Pulmonol JT - Pediatric pulmonology JID - 8510590 SB - IM MH - Adolescent MH - Adult MH - Child MH - Female MH - Humans MH - Male MH - Young Adult MH - *Cystic Fibrosis/therapy/physiopathology MH - *Exercise Therapy/methods MH - Feasibility Studies MH - Interviews as Topic MH - Qualitative Research MH - *Respiratory Therapy/methods PMC - PMC12834544 OTO - NOTNLM OT - chest physiotherapy OT - cystic fibrosis OT - physical activity OT - qualitative OT - semi-structured interviews COIS- The authors declare no conflicts of interest. FIR - Urquhart, Don S IR - Urquhart DS IRAD- Department of Child Life and Health, University of Edinburgh, Edinburgh, UK. IRAD- Department of Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children and Young People, Edinburgh, UK. FIR - Taylor, Emily IR - Taylor E IRAD- Department of Child Life and Health, University of Edinburgh, Edinburgh, UK. IRAD- Department of Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children and Young People, Edinburgh, UK. FIR - Cunningham, Steve IR - Cunningham S IRAD- Department of Child Life and Health, University of Edinburgh, Edinburgh, UK. IRAD- Department of Paediatric Respiratory and Sleep Medicine, Royal Hospital for Children and Young People, Edinburgh, UK. IRAD- Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK. FIR - Lewis, Steff IR - Lewis S IRAD- Usher Institute, Edinburgh Clinical Trials Unit, NINE Edinburgh Bioquarter, University of Edinburgh, Edinburgh, France. FIR - Neilson, Aileen Rae IR - Neilson AR IRAD- Usher Institute, Edinburgh Clinical Trials Unit, NINE Edinburgh Bioquarter, University of Edinburgh, Edinburgh, France. FIR - Soilemezi, Dia IR - Soilemezi D IRAD- Department of Psychology, Faculty of Science and Health, University of Portsmouth, Portsmouth, UK. FIR - Ensor, Hannah IR - Ensor H IRAD- Usher Institute, Edinburgh Clinical Trials Unit, NINE Edinburgh Bioquarter, University of Edinburgh, Edinburgh, France. FIR - Vogiatizis, Ioannis IR - Vogiatizis I IRAD- Department of Sport, Exercise and Rehabilitation, Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK. FIR - Allen, Lorna IR - Allen L IRAD- Cystic Fibrosis Trust, One Aldgate, Second Floor, London, UK. FIR - Miller, Debbie IR - Miller D IRAD- Adult Cystic Fibrosis Unit, Western General Hospital, Edinburgh, UK. FIR - Bowen, Donna IR - Bowen D IRAD- NIHR Southampton Clinical Research Facility, University Hospitals Southampton NHS Foundation Trust, Southampton, UK. FIR - Kilarski, Ellyse IR - Kilarski E IRAD- Adult Cystic Fibrosis Unit, Western General Hospital, Edinburgh, UK. FIR - Lacey, Ellen IR - Lacey E IRAD- NIHR Southampton Clinical Research Facility, University Hospitals Southampton NHS Foundation Trust, Southampton, UK. FIR - Connett, Gary IR - Connett G IRAD- National Institute for Health and Care Research, Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK. IRAD- Department of Paediatric Respiratory Medicine, University Hospital Southampton NHS Foundation Trust, Southampton, UK. FIR - Legg, Julian IR - Legg J IRAD- Department of Paediatric Respiratory Medicine, University Hospital Southampton NHS Foundation Trust, Southampton, UK. FIR - Evans, Hazel IR - Evans H IRAD- Department of Paediatric Respiratory Medicine, University Hospital Southampton NHS Foundation Trust, Southampton, UK. FIR - Daniels, Thomas IR - Daniels T IRAD- Wessex Cystic Fibrosis Unit, University Hospitals Southampton NHS Foundation Trust, Southampton, UK. IRAD- National Institute for Health and Care Research, Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK. FIR - Allenby, Mark IR - Allenby M IRAD- Wessex Cystic Fibrosis Unit, University Hospitals Southampton NHS Foundation Trust, Southampton, UK. FIR - Carroll, Mary IR - Carroll M IRAD- Wessex Cystic Fibrosis Unit, University Hospitals Southampton NHS Foundation Trust, Southampton, UK. FIR - Gray, Robert IR - Gray R IRAD- Adult Cystic Fibrosis Unit, Western General Hospital, Edinburgh, UK. FIR - Echevarria, Carlos IR - Echevarria C IRAD- Adult Cystic Fibrosis Unit, Royal Victoria Infirmary, Newcastle-upon-Tyne, UK. FIR - Morrison, Lisa IR - Morrison L IRAD- West of Scotland Adult CF Unit, Queen Elizabeth University Hospital, Glasgow, UK. FIR - McGregor, Gordon IR - McGregor G IRAD- West of Scotland Adult CF Unit, Queen Elizabeth University Hospital, Glasgow, UK. FIR - Abkir, Mary IR - Abkir M IRAD- Royal Brompton & Harefield Hospitals, part of Guys and St Thomas' NHS Foundation Trust, London, UK. IRAD- National Heart and Lung Institute, Imperial College London, London, UK. IRAD- European Cystic Fibrosis Society, Lung Clearance Index Core Facility, London, UK. FIR - Saunders, Clare IR - Saunders C IRAD- Royal Brompton & Harefield Hospitals, part of Guys and St Thomas' NHS Foundation Trust, London, UK. IRAD- National Heart and Lung Institute, Imperial College London, London, UK. IRAD- European Cystic Fibrosis Society, Lung Clearance Index Core Facility, London, UK. FIR - Saynor, Zoe L IR - Saynor ZL IRAD- School of Health Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Southampton, UK. IRAD- Wessex Cystic Fibrosis Unit, University Hospitals Southampton NHS Foundation Trust, Southampton, UK. IRAD- National Institute for Health and Care Research, Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK. EDAT- 2026/01/26 18:28 MHDA- 2026/01/26 18:29 PMCR- 2026/01/26 CRDT- 2026/01/26 16:13 PHST- 2025/12/02 00:00 [revised] PHST- 2025/07/09 00:00 [received] PHST- 2026/01/11 00:00 [accepted] PHST- 2026/01/26 18:29 [medline] PHST- 2026/01/26 18:28 [pubmed] PHST- 2026/01/26 16:13 [entrez] PHST- 2026/01/26 00:00 [pmc-release] AID - PPUL71470 [pii] AID - 10.1002/ppul.71470 [doi] PST - ppublish SO - Pediatr Pulmonol. 2026 Jan;61(1):e71470. doi: 10.1002/ppul.71470. PMID- 41585298 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260126 LR - 20260128 IS - 2055-2076 (Print) IS - 2055-2076 (Electronic) IS - 2055-2076 (Linking) VI - 12 DP - 2026 Jan-Dec TI - Development and validation of a multimodal data collection system for adolescent mental health management. PG - 20552076261415916 LID - 10.1177/20552076261415916 [doi] LID - 20552076261415916 AB - OBJECTIVE: Adolescence is a critical developmental stage during which mental health vulnerabilities often emerge. Traditional self-report methods are insufficient to capture the complexity of emotional and physiological responses, underscoring the need for data-driven, personalized mental health strategies. This study aimed to develop and validate a structured multimodal data collection system for adolescents to support the future advancement of precision mental health care. METHODS: This study was conducted as the baseline phase of a longitudinal panel study designed to construct and validate a structured multimodal dataset for adolescent mental health research. A total of 74 adolescents aged 11-15 years from schools and community facilities in Korea was selected through convenience sampling. Multimodal data were collected by integrating six data types: self-reported surveys, electroencephalography (EEG), heart rate variability (HRV), genotyping, microbiome data, and video-based psychological counseling. Data collection was standardized through a three-phase protocol (pre-, on-site, and post-assessment), and participant privacy was protected via pseudonymization based on international standards. Variables were systematically labeled and structured to enable cross-modality analysis. Statistical analyses, including correlation and descriptive statistics, were performed to examine preliminary relationships across modalities. RESULTS: The study successfully constructed a comprehensive dataset encompassing biological and psychosocial indicators from 74 adolescents. Preliminary analysis revealed statistically significant associations between survey-based BMI and both genomic data (rho = 0.30, p < 0.01) and microbiome-based obesity indicators (rho = 0.27, p < 0.05), whereas other psychological constructs (e.g., stress, resilience) showed non-significant cross-modal correlations. CONCLUSIONS: This study presents a replicable framework for collecting rich, multimodal data from adolescents in real-world settings. By enabling integrative analysis of biological and psychosocial variables, the dataset lays the groundwork for personalized mental health prediction and intervention strategies. Future research should expand longitudinally and optimize context alignment to improve predictive precision and clinical utility. CI - (c) The Author(s) 2026. FAU - Ko, Siyeon AU - Ko S AUID- ORCID: 0000-0002-6610-6751 AD - Department of Health Administration, Kongju National University, Gongju, Republic of Korea. FAU - Oh, Kyoungsu AU - Oh K AUID- ORCID: 0000-0002-3177-8793 AD - Department of IT Convergence Engineering, Gachon University, Seongnam-si, Republic of Korea. RINGGOLD: 65440 FAU - Won, Uhyeong AU - Won U AUID- ORCID: 0009-0006-4039-5889 AD - Department of IT Convergence Engineering, Gachon University, Seongnam-si, Republic of Korea. RINGGOLD: 65440 FAU - Oh, Jung-A AU - Oh JA AUID- ORCID: 0000-0003-0918-2595 AD - Chungnam Public Agency for Social Service, Gongju, Republic of Korea. FAU - Kwon, Nak-Jung AU - Kwon NJ AUID- ORCID: 0000-0003-0874-4146 AD - Macrogen Inc., Seoul, Republic of Korea. RINGGOLD: 65603 FAU - Park, Hyun-Sook AU - Park HS AD - Department of Social Welfare, Kyungsung University, Suyeong-ro, Nam-gu, Republic of Korea. RINGGOLD: 34987 FAU - Ji, Young-A AU - Ji YA AUID- ORCID: 0000-0003-3202-7809 AD - Department of Medical Education, School of Medicine, Sungkyunkwan University, Gangnam-gu, Seoul, Republic of Korea. FAU - Kim, Sungjin AU - Kim S AD - Ybrain Inc., Seoul, Republic of Korea. RINGGOLD: 644775 FAU - Moon, Yonghwan AU - Moon Y AUID- ORCID: 0009-0001-9239-4304 AD - Department of Health Administration, Kongju National University, Gongju, Republic of Korea. FAU - Park, Nayoung AU - Park N AUID- ORCID: 0009-0000-0825-402X AD - Department of Health Administration, Kongju National University, Gongju, Republic of Korea. FAU - Kim, Dohyoung AU - Kim D AUID- ORCID: 0009-0001-7882-6158 AD - Department of IT Convergence Engineering, Gachon University, Seongnam-si, Republic of Korea. RINGGOLD: 65440 FAU - Yang, Euijun AU - Yang E AUID- ORCID: 0009-0008-3589-8152 AD - Department of Health Administration, Kongju National University, Gongju, Republic of Korea. FAU - Na, Kyungmin AU - Na K AUID- ORCID: 0009-0006-1256-530X AD - Department of IT Convergence Engineering, Gachon University, Seongnam-si, Republic of Korea. RINGGOLD: 65440 FAU - Kim, Yeonju AU - Kim Y AUID- ORCID: 0009-0004-3650-6393 AD - Department of Health Administration, Kongju National University, Gongju, Republic of Korea. FAU - Lee, Youngho AU - Lee Y AUID- ORCID: 0000-0003-0720-0569 AD - Department of IT Computer Engineering, Gachon University, Sungnam-si, Republic of Korea. FAU - Woo, Hyekyung AU - Woo H AUID- ORCID: 0000-0001-5489-3404 AD - Department of Health Administration, Kongju National University, Gongju, Republic of Korea. LA - eng PT - Journal Article DEP - 20260121 PL - United States TA - Digit Health JT - Digital health JID - 101690863 PMC - PMC12830548 OTO - NOTNLM OT - Adolescent mental health OT - digital phenotyping OT - multimodal data integration OT - precision psychiatry COIS- The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/01/26 14:55 MHDA- 2026/01/26 14:56 PMCR- 2026/01/21 CRDT- 2026/01/26 07:02 PHST- 2025/07/03 00:00 [received] PHST- 2025/12/31 00:00 [accepted] PHST- 2026/01/26 14:56 [medline] PHST- 2026/01/26 14:55 [pubmed] PHST- 2026/01/26 07:02 [entrez] PHST- 2026/01/21 00:00 [pmc-release] AID - 10.1177_20552076261415916 [pii] AID - 10.1177/20552076261415916 [doi] PST - epublish SO - Digit Health. 2026 Jan 21;12:20552076261415916. doi: 10.1177/20552076261415916. eCollection 2026 Jan-Dec. PMID- 41584507 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 1118-4841 (Print) IS - 1118-4841 (Linking) VI - 30 IP - 2 DP - 2026 Jan 26 TI - Maternal well-being in the postpartum period: The mediating role of breastfeeding self-efficacy, sleep quality, and husband's support. PG - 61-69 LID - 10.29063/ajrh2026/v30i2.5 [doi] AB - Maternal health postpartum is important for both maternal and infant health. Support from husbands is a major factor but its role is still not well understood in our cultural context, in Pariaman, Indonesia. The relationship between husband support and maternal well-being with the mediation of breastfeeding self-efficacy and sleep quality was also an area for investigation in this study. A cross-sectional study was carried out in the months between March to August 202143 among postpartum women in urban and semi-urban areas of Pariaman City, West Sumatra. Validated questionnaires such as the Husband's Support Scale for Postpartum Mothers, Breastfeeding Self-Efficacy Scale Short Form, Pittsburgh Sleep Quality Index and WHO-5 Well-Being Index were used to measure data analysed by Pearson correlation (cr) and Structural Equation Modeling with bootstrapping. Husband's support was significantly associated with breastfeeding self-efficacy (r = 0.54) and maternal well-being (r = 0.49), and negative with poor sleep (r = -0.41; all p < 0.01). The model showed a moderate direct effect of husband's support on well-being (beta = 0.28, p < 0.008) and indirect effects mediated by breastfeeding self-efficacy (beta = 0.19) and sleep quality (beta = 0.15), accounting for 42% of the variance in well-being. The findings of this study underline that involvement of husband correlates with better well-being of the mother in terms of increased confidence about breastfeeding and better sleep quality. CI - African Journal of Reproductive Health (c) 2026. FAU - Oktavia, Sesmi N AU - Oktavia SN AD - Lincoln University College, Malaysia. FAU - Kanathasan, Jayasree S AU - Kanathasan JS AD - Pasaman Barat Midwifery Academy, Indonesia. LA - eng PT - Journal Article PL - Nigeria TA - Afr J Reprod Health JT - African journal of reproductive health JID - 9712263 SB - IM MH - Humans MH - Female MH - *Breast Feeding/psychology MH - *Self Efficacy MH - *Postpartum Period/psychology MH - Cross-Sectional Studies MH - *Sleep Quality MH - Adult MH - *Spouses/psychology MH - Indonesia MH - *Mothers/psychology MH - *Social Support MH - Surveys and Questionnaires MH - Family Support MH - Psychological Well-Being MH - Young Adult MH - *Sleep OTO - NOTNLM OT - Breast Feeding OT - Maternal Health OT - Sleep Quality COIS- The Authors declared no conflict of interest EDAT- 2026/01/26 14:54 MHDA- 2026/01/26 14:55 CRDT- 2026/01/26 06:56 PHST- 2026/01/26 14:55 [medline] PHST- 2026/01/26 14:54 [pubmed] PHST- 2026/01/26 06:56 [entrez] AID - Afr J Reprod Health 2026; 30 [2]: 61-69 [pii] AID - 10.29063/ajrh2026/v30i2.5 [doi] PST - ppublish SO - Afr J Reprod Health. 2026 Jan 26;30(2):61-69. doi: 10.29063/ajrh2026/v30i2.5. PMID- 41584187 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260707 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Healthy food and dietary patterns: a cross-sectional study in Riyadh, Saudi Arabia. PG - 1716376 LID - 10.3389/fpubh.2025.1716376 [doi] LID - 1716376 AB - BACKGROUND: The escalating prevalence of obesity represents a critical public health challenge, especially in Saudi Arabia, where more than 65% of the population is classified as obese. This condition is closely associated with increased mortality and a heightened risk of chronic illnesses such as diabetes and cardiovascular disease. AIM: This study aims to assess the level of awareness and perceptions regarding healthy dietary choices among individuals in Riyadh, Saudi Arabia. METHODS: A cross-sectional study was conducted in Riyadh, Saudi Arabia, from December 2024 to February 2025, using a convenience sampling method. Adults aged 18 years and older were invited to participate via an online self-administered bilingual questionnaire. The survey assessed knowledge, perceptions, and barriers related to healthy eating. A total of 385 responses were targeted. The questionnaire was adapted from validated tools and an expert checked the questionnaire for clarity and cultural relevance, and suggestions were used to improve it. Internal consistency (reliability) of the final survey items was assessed using Cronbach's alpha, which was 0.6. Descriptive statistics and linear regression analyses were used to explore the associations between sociodemographic factors and knowledge scores. All analyses were performed using SPSS version 29. RESULTS: After adjusting for confounding variables, being married was significantly associated with higher knowledge of healthy foods (adjusted beta = 1.337 [95% CI: 0.097 to 2.576], p = 0.035). Arabic speakers displayed significantly lower knowledge of healthy foods than English speakers (Adjusted beta = -1.555 [95% CI: -2.318 to -0.792], p < 0.001). Additionally, individuals with a bachelor's degree or higher had significantly lower knowledge of healthy foods than those with only a high school diploma (Adjusted beta = -0.842 [95% CI: -1.651 to -0.034], p = 0.041). CONCLUSION: This study highlights notable disparities in dietary knowledge across demographic groups in Riyadh, Saudi Arabia. The findings underscore the need for tailored public health strategies that specifically address young adults, Arabic-speaking populations, and individuals with higher educational attainment, who surprisingly demonstrated lower levels of dietary knowledge. Culturally sensitive, language-specific, and age-appropriate educational interventions are critical to improving awareness of healthy eating habits and ultimately reducing the burden of obesity and related health complications in Saudi society. LIMITATIONS: The study was done in Riyadh, Saudi Arabia, limiting the generalizability of our findings as nutritional knowledge may vary in other regions of the country. Many people find it challenging to eat healthy in Riyadh due to the city's fast-paced culture, with factors such as time constraints, low motivation, cost, and a lack of support all contributing to poor food choices. Moreover, self-reported data in cross-sectional studies can introduce reporting and recall biases. The use of convenience sampling may have led to selection bias, and factors like comorbidities may limit how well the findings apply to the wider population. CI - Copyright (c) 2026 Alhusseini, Sajjad, Rahman, Naimi, Jamal, Raziq, Khan, Raddawi, Raddaoui, Omair, AlNasser, Alsouss, Tamim and Ateq. FAU - Alhusseini, Noara AU - Alhusseini N AD - Department of Biostatistics, Epidemiology and Public Health, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. FAU - Sajjad, Maryam AU - Sajjad M AD - Department of Biostatistics, Epidemiology and Public Health, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. FAU - Rahman, Heba AU - Rahman H AD - Department of Biostatistics, Epidemiology and Public Health, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. FAU - Naimi, Hamna AU - Naimi H AD - Department of Biostatistics, Epidemiology and Public Health, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. FAU - Jamal, Madiha AU - Jamal M AD - Department of Biostatistics, Epidemiology and Public Health, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. FAU - Raziq, Tehreemah AU - Raziq T AD - Department of Biostatistics, Epidemiology and Public Health, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. FAU - Khan, Zainab AU - Khan Z AD - Department of Biostatistics, Epidemiology and Public Health, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. FAU - Raddawi, Saed Fawaz AU - Raddawi SF AD - Department of Biostatistics, Epidemiology and Public Health, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. FAU - Raddaoui, Layla AU - Raddaoui L AD - Department of Biostatistics, Epidemiology and Public Health, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. FAU - Omair, Aamir AU - Omair A AD - Research Unit, College of Medicine, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia. FAU - AlNasser, Sara Khalid AU - AlNasser SK AD - Department of Biostatistics, Epidemiology and Public Health, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. AD - Communication and swallowing Disorder Division, Prince Sultan Military Medical City, Riyadh, Saudi Arabia. FAU - Alsouss, Yara Obaeda AU - Alsouss YO AD - Department of Biostatistics, Epidemiology and Public Health, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. FAU - Tamim, Hala AU - Tamim H AD - Kinesiology and Health Science, York University, Toronto, ON, Canada. FAU - Ateq, Khadijah AU - Ateq K AD - Department of Biostatistics, Epidemiology and Public Health, College of Medicine, Alfaisal University, Riyadh, Saudi Arabia. AD - Research Office, King Abdullah International Medical Research Center, King Saud Bin Abdulaziz University for Health Science, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20260109 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Saudi Arabia MH - Cross-Sectional Studies MH - Male MH - Adult MH - Female MH - *Health Knowledge, Attitudes, Practice MH - Middle Aged MH - *Diet, Healthy/statistics & numerical data MH - Surveys and Questionnaires MH - Young Adult MH - Adolescent MH - Obesity MH - *Feeding Behavior MH - Middle Eastern People MH - Aged PMC - PMC12827757 OTO - NOTNLM OT - Saudi Arabia OT - cross sectional study OT - health education OT - healthy dietary OT - nutritional knowledge OT - obesity OT - public health COIS- The author(s) declared that that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/26 14:54 MHDA- 2026/01/26 14:55 PMCR- 2026/01/09 CRDT- 2026/01/26 06:54 PHST- 2025/09/30 00:00 [received] PHST- 2025/11/27 00:00 [revised] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/01/26 14:55 [medline] PHST- 2026/01/26 14:54 [pubmed] PHST- 2026/01/26 06:54 [entrez] PHST- 2026/01/09 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1716376 [doi] PST - epublish SO - Front Public Health. 2026 Jan 9;13:1716376. doi: 10.3389/fpubh.2025.1716376. eCollection 2025. PMID- 41584144 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - The relationship between family physical activity environment and mental health in high school students: the chain mediating role of parent-child relationship and exercise behavior. PG - 1719426 LID - 10.3389/fpubh.2025.1719426 [doi] LID - 1719426 AB - INTRODUCTION: Adolescence is a high-incidence period for mental health problems. Evidence suggests that the family physical activity (PA) environment may shape adolescents' psychological well-being, but the underlying mechanisms remain unclear. This study examined whether the parent-child relationship and adolescents' own exercise behaviour serially mediate the association between the family PA environment and mental health among Chinese seniorhigh-school students. METHODS: A cross-sectional survey was conducted among 2,049 senior-high-school students (mean age = 15.7 +/- 1.2 years; 52 % girls) recruited from six provinces in China. Validated instruments were used to assess the family PA environment (Family Physical Activity Environment Questionnaire), mental health problems (Mental Health Diagnostic Test), parent-child relationship quality (Parent-Child Relationship Scale), and exercise behaviour (Physical Activity Rating Scale). Structural equation modelling was employed to test direct and indirect effects, with sex, age, and socioeconomic status as covariates. RESULTS: The family PA environment was significantly and positively associated with mental health (beta = 0.31, p < 0.001). The parent-child relationship and exercise behaviour each independently mediated this association (indirect effect beta = 0.09, 95 % CI 0.06-0.12; beta = 0.07, 95 % CI 0.04-0.10, respectively). A significant chain-mediating effect was also observed (beta = 0.05, 95 % CI 0.03-0.07), indicating that a supportive family PA environment improved relationship quality, which in turn promoted exercise behaviour and subsequently better mental health. The total mediated effect accounted for 41 % of the overall association. DISCUSSION: Findings underscore the family PA environment as a critical determinant of adolescents' mental health. Intervention programmes that simultaneously strengthen family-based physical activity and parent-child relationship quality may confer synergistic benefits for adolescent psychological well-being. CI - Copyright (c) 2026 Feng and Xu. FAU - Feng, Xuezhen AU - Feng X AD - College of Educational Science, Xinjiang Normal University, Urumqi, China. FAU - Xu, Enwei AU - Xu E AD - College of Educational Science, Xinjiang Normal University, Urumqi, China. LA - eng PT - Journal Article DEP - 20260108 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - Adolescent MH - *Exercise/psychology MH - *Parent-Child Relations MH - *Mental Health/statistics & numerical data MH - Cross-Sectional Studies MH - China MH - Male MH - *Students/psychology/statistics & numerical data MH - Surveys and Questionnaires MH - Adolescent Behavior/psychology PMC - PMC12823837 OTO - NOTNLM OT - exercise behavior OT - family physical activity environment OT - high school students OT - mental health OT - parent-child relationship COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/26 14:55 MHDA- 2026/01/26 14:56 PMCR- 2026/01/08 CRDT- 2026/01/26 06:53 PHST- 2025/10/06 00:00 [received] PHST- 2025/11/09 00:00 [revised] PHST- 2025/12/15 00:00 [accepted] PHST- 2026/01/26 14:56 [medline] PHST- 2026/01/26 14:55 [pubmed] PHST- 2026/01/26 06:53 [entrez] PHST- 2026/01/08 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1719426 [doi] PST - epublish SO - Front Public Health. 2026 Jan 8;13:1719426. doi: 10.3389/fpubh.2025.1719426. eCollection 2025. PMID- 41583766 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260126 LR - 20260128 IS - 1664-1078 (Print) IS - 1664-1078 (Electronic) IS - 1664-1078 (Linking) VI - 16 DP - 2025 TI - Who participates? Who frequents? Exploring the correlates of sports participation among Chinese adults: evidence from national survey. PG - 1621125 LID - 10.3389/fpsyg.2025.1621125 [doi] LID - 1621125 AB - BACKGROUND: Although the benefits of sports participation (SP)-such as reduced anxiety and depression and improved physical health-are well-established, physical inactivity continues to rise globally. In China, the proportion of adults regularly participating in sports remains low, underscoring the need for targeted interventions. However, research on the correlates of SP among Chinese adults is scarce. Given that correlates may differ across countries and between specific participation behaviors, it is essential to differentiate between types of participation to conduct a comprehensive analysis of the correlates of SP among Chinese adults. The objective of this study is to incorporate a broad range of independent variables validated in prior literature to conduct a comprehensive analysis of sports participation among Chinese adults, thereby providing empirical evidence for precise intervention strategies and future research directions. METHODS: Using data from the 2021 China General Social Survey (CGSS), this study included 22 independent variables previously validated as significantly associated with SP. Three outcome variables of SP among Chinese adults were analyzed in this study: (1) whether participation, (2) participation frequency, and (3) frequent participation. The full dataset (n = 5,581) was used to examine the correlates of whether to participate, while a subsample of sports participants (n = 3,491) was used for the other two outcomes. Analyses involved descriptive statistics, univariate analysis, and backward stepwise regression. RESULTS: Twelve variables-including provincial economies, settlement type, education, BMI, health issues influence, depression, internet access, watch competition, social class, economic status, car ownership, and age-were significantly associated with whether participation (all p < 0.05 across all regression models). Seven variables, including provincial economies, settlement type, health issues influence, depression, migration, children, and age, were significantly associated with both participation frequency and frequent participation (all p < 0.05 across all regression models). CONCLUSION: This study provides innovative insights into the correlates of SP among Chinese adults, with age, gender, depression, and migration showing patterns that differ from existing literature. While participation frequency and frequent participation show similar correlates, they differ significantly from the correlates of whether participation, highlighting the need for differentiated intervention strategies. CI - Copyright (c) 2026 Chao, Wang and Chang. FAU - Chao, Yizhen AU - Chao Y AD - The Wushu Association of Dengzhou City, Dengzhou, Henan, China. FAU - Wang, Yaqing AU - Wang Y AD - The Wushu Association of Dengzhou City, Dengzhou, Henan, China. FAU - Chang, Zhenzhan AU - Chang Z AD - Department of Biochemistry and Biophysics, School of Basic Medical Sciences, Peking University, Beijing, China. LA - eng PT - Journal Article DEP - 20260109 PL - Switzerland TA - Front Psychol JT - Frontiers in psychology JID - 101550902 PMC - PMC12827589 OTO - NOTNLM OT - China OT - adults OT - correlates OT - health behavior OT - non-communicable diseases OT - physical activity OT - public health promotion OT - sports participation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/26 12:54 MHDA- 2026/01/26 12:55 PMCR- 2026/01/09 CRDT- 2026/01/26 06:50 PHST- 2025/05/22 00:00 [received] PHST- 2025/12/29 00:00 [revised] PHST- 2025/12/29 00:00 [accepted] PHST- 2026/01/26 12:55 [medline] PHST- 2026/01/26 12:54 [pubmed] PHST- 2026/01/26 06:50 [entrez] PHST- 2026/01/09 00:00 [pmc-release] AID - 10.3389/fpsyg.2025.1621125 [doi] PST - epublish SO - Front Psychol. 2026 Jan 9;16:1621125. doi: 10.3389/fpsyg.2025.1621125. eCollection 2025. PMID- 41583686 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260126 LR - 20260128 IS - 2772-6282 (Electronic) IS - 2772-6282 (Linking) VI - 8 DP - 2026 Jun TI - Development and validation of a questionnaire to assess primary health professional's knowledge of weight management counseling of adolescents in Indonesia. PG - 100454 LID - 10.1016/j.pecinn.2026.100454 [doi] LID - 100454 AB - OBJECTIVE: This study set out to develop and validate a measure of primary health professionals' knowledge of counseling for weight management in adolescent patients in Indonesia. METHODS: A literature review informed the development of an initial set of items. These were refined following content and face validity testing from expert panels. Item Difficulty Index and Discrimination Index were used to perform item analysis, and reliability (Cronbach alpha) was tested with 67 primary care practitioners from 30 out of Indonesia's 34 provinces. RESULTS: An initial set of 114 questions was identified and arranged within three sections (healthy eating, physical activity, and behavioral change counseling skills). A series of validation processes resulted in 47 items with an acceptable Item Difficulty Index and Discrimination Index (0.2-0.9), and with sound internal consistency (Cronbach alpha coefficient 0.786). INNOVATION: This measure lays a foundation to evaluate future interventions to improve health professionals' capacity to address obesity within clinical practice. CONCLUSION: The developed questionnaire is a valid and reliable 47-item instrument to measure primary health professionals' knowledge of weight management counseling for adolescent patients. CI - (c) 2026 The Authors. FAU - Agung, Fransisca Handy AU - Agung FH AD - Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia. FAU - Sekartini, Rini AU - Sekartini R AD - Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. FAU - Sudarsono, Nani Cahyani AU - Sudarsono NC AD - Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. FAU - Hendarto, Aryono AU - Hendarto A AD - Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. FAU - Werdhani, Retno Asti AU - Werdhani RA AD - Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. FAU - Dhamayanti, Meita AU - Dhamayanti M AD - Department of Child Health, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia. FAU - Pudjiati, Sri Retno AU - Pudjiati SR AD - Faculty of Psychology, Universitas Indonesia, Kampus UI, Depok, Indonesia. FAU - Hanum, Lathifah AU - Hanum L AD - Faculty of Psychology, Universitas Indonesia, Kampus UI, Depok, Indonesia. FAU - Mubarokah, Khairunisa AU - Mubarokah K AD - Indonesian Adolescent Health Association, Tangerang, Indonesia. FAU - Setyannisa, Astrid AU - Setyannisa A AD - Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia. FAU - Naufal, Affan AU - Naufal A AD - Balaraja District Hospital, Tangerang, Indonesia. FAU - Sawyer, Susan M AU - Sawyer SM AD - Centre for Adolescent Health, Royal Children's Hospital, Murdoch Children's Research, Institute, and Department of Paediatrics, The University of Melbourne, Melbourne, Australia. LA - eng PT - Journal Article DEP - 20260105 PL - Netherlands TA - PEC Innov JT - PEC innovation JID - 9918367980406676 PMC - PMC12830229 OTO - NOTNLM OT - Adolescents OT - Counseling OT - Health professional OT - Knowledge OT - Obesity OT - Weight management COIS- There is no potential conflict of interest both real and perceived for all named authors. EDAT- 2026/01/26 14:54 MHDA- 2026/01/26 14:55 PMCR- 2026/01/05 CRDT- 2026/01/26 06:49 PHST- 2025/01/13 00:00 [received] PHST- 2025/12/21 00:00 [revised] PHST- 2026/01/03 00:00 [accepted] PHST- 2026/01/26 14:55 [medline] PHST- 2026/01/26 14:54 [pubmed] PHST- 2026/01/26 06:49 [entrez] PHST- 2026/01/05 00:00 [pmc-release] AID - S2772-6282(26)00001-4 [pii] AID - 100454 [pii] AID - 10.1016/j.pecinn.2026.100454 [doi] PST - epublish SO - PEC Innov. 2026 Jan 5;8:100454. doi: 10.1016/j.pecinn.2026.100454. eCollection 2026 Jun. PMID- 41583285 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260126 LR - 20260128 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 12 DP - 2025 Dec TI - Prenatal Lipid-Based Supplementation and Infant Weight-for-Length Z-score Outcomes in the First Year of Life: Evidence From a Community-Based Trial in Pakistan. PG - e99920 LID - 10.7759/cureus.99920 [doi] LID - e99920 AB - Background The tribal belt of Pakistan continues to present the highest tendencies of acute malnutrition, a challenge commonly affecting children's growth in infancy across South Asia. Whilst maternal lipid-based nutrient supplements have shown promising results, their effectiveness varies by formulation, dosage, and context. This study evaluated whether providing mothers with medium-quantity lipid-based nutrient supplements (MQ-LNS) during their pregnancy and six months postpartum could improve infant weight-for-length Z-scores (WLZs) at 12 months of age in a food-insecure district of Pakistan. Methodology This study used a community-based, non-randomized controlled trial design in Upper Kurram, Khyber Pakhtunkhwa, from February 2019 through January 2020. Cluster formation was based on Lady Health Worker catchment areas. The study provided Maamta MQ-LNS (75 g/day) to pregnant women from conception through six months of postpartum care. The control group received standard antenatal care (ANC) with iron-folic acid (IFA). The main study result consisted of WLZ measurements based on WHO standards at the 12-month follow-up. The study used multivariable linear regression with cluster-robust standard errors to establish effect sizes and inverse probability of treatment weighting to handle baseline differences. The research evaluated two additional outcomes through length-for-age z-score (HAZ) and wasting (WLZ < -2). Results The study results demonstrated that children whose mothers received MQ-LNS from pregnancy through the first half year of life gained better WLZ than control children at 12 months (adjusted beta = 0.29; 95% confidence interval = 0.08-0.51; p = 0.007). The results showed no change in the difference after controlling for maternal and household variables. Mean HAZ was slightly higher in the intervention group (p = 0.038), while the proportion wasted (WLZ < -2) did not differ significantly between groups. Conclusions The research showed that rural mothers who consumed MQ-LNS during pregnancy and early postpartum delivered infants who had better WLZ at 12 months in a food-insecure setting. The findings showed a higher level of nutritional benefits than the standard prenatal small-quantity lipid-based nutrient supplement program, which indicates that MQ-LNS could provide additional benefit in cases of severe nutritional deficiencies. Policy integration within ANC and social protection initiatives, including the Benazir Nashonuma Programme, warrants consideration, alongside assessments of adherence, cost-effectiveness, and supply feasibility. CI - Copyright (c) 2025, Habib et al. FAU - Habib, Ijaz AU - Habib I AD - Institute of Public Health and Social Sciences, Khyber Medical University, Peshawar, PAK. FAU - Fazid, Sheraz AU - Fazid S AD - Institute of Public Health and Social Sciences, Khyber Medical University, Peshawar, PAK. FAU - Tanimoune, Mahamadou AU - Tanimoune M AD - Nutrition, United Nations, World Food Programme, Islamabad, PAK. FAU - Garzon, Cecilia AU - Garzon C AD - Nutrition, United Nations, World Food Programme, Islamabad, PAK. FAU - Ihtesham, Yasir AU - Ihtesham Y AD - Nutrition, United Nations, World Food Programme, Islamabad, PAK. FAU - Dad, Fazal AU - Dad F AD - Nutrition, United Nations, World Food Programme, Peshawar, PAK. FAU - Ul Haq, Zia AU - Ul Haq Z AD - Public Health, University of Glasgow, Glasgow, GBR. AD - Institute of Public Health and Social Sciences, Khyber Medical University, Peshawar, PAK. LA - eng PT - Journal Article DEP - 20251223 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12825317 OTO - NOTNLM OT - antenatal care OT - benazir nashonuma programme OT - cluster-adjusted analysis OT - haz OT - iptw OT - lipid-based nutrient supplements OT - mq-lns OT - pakistan OT - wasting OT - wlz/whz COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Khyber Medical University Ethics Review Board issued approval Ref DIR/KMU-EB/SP/000427-28-08-2017. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/01/26 12:57 MHDA- 2026/01/26 12:58 PMCR- 2025/12/23 CRDT- 2026/01/26 06:46 PHST- 2025/12/21 00:00 [accepted] PHST- 2026/01/26 12:58 [medline] PHST- 2026/01/26 12:57 [pubmed] PHST- 2026/01/26 06:46 [entrez] PHST- 2025/12/23 00:00 [pmc-release] AID - 10.7759/cureus.99920 [doi] PST - epublish SO - Cureus. 2025 Dec 23;17(12):e99920. doi: 10.7759/cureus.99920. eCollection 2025 Dec. PMID- 41582741 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260813 IS - 1612-1880 (Electronic) IS - 1612-1872 (Print) IS - 1612-1872 (Linking) VI - 23 IP - 1 DP - 2026 Jan TI - Dahuang Huanglian Xiexin Decoction Ameliorates Obesity by Targeting the PPARgamma/STAT3/PTGS2 Axis: Integrative Network Pharmacology and Experimental Validation. PG - e01831 LID - 10.1002/cbdv.202501831 [doi] LID - e01831 AB - Childhood obesity is a major preventable health issue. This study evaluated the anti-obesity effects of Dahuang Huanglian Xiexin Decoction (DHXD) and explored its potential mechanisms using network pharmacology and molecular docking. Active compounds and targets of DHXD were identified from TCMSP and HERB databases, while obesity-related targets were obtained from GeneCards, TTD, and DisGeNET. A protein-protein interaction network helped identify 45 shared targets and 10 hub genes. Molecular docking confirmed strong binding between DHXD components and key targets. An obesity rat model was established using a high-fat diet, followed by DHXD treatment. Parameters such as body weight, fat mass, and rectal temperature were monitored. Biochemical assays and histological staining assessed metabolic and tissue changes. Western blotting evaluated the expression of obesity-related proteins. Results showed DHXD significantly reduced body weight and fat accumulation, improved blood glucose and lipid profiles, and promoted lipolysis and browning of white adipose tissue. Molecular analysis highlighted PPARgamma, PTGS2, and STAT3 as central targets mediating DHXD's anti-obesity effects. These findings support the potential of DHXD as an effective therapeutic agent against obesity and provide insights into its molecular mechanism of action. CI - (c) 2026 Wiley-VHCA AG. FAU - Gu, Huan AU - Gu H AD - Department of Integrative Cardiology, China-Japan Friendship Hospital, Beijing, P. R. China. FAU - Yang, Lichang AU - Yang L AD - Graduate School, Nanjing University of Chinese Medicine, Nanjing, P. R. China. FAU - Hao, Long AU - Hao L AD - Department of Pediatrics, Beijing Fangshan District Liangxiang Hospital, Beijing, P. R. China. FAU - Li, Mingxi AU - Li M AD - Department of Pediatrics, Beijing Fangshan District Liangxiang Hospital, Beijing, P. R. China. FAU - Li, Ji AU - Li J AUID- ORCID: 0009-0003-5678-5919 AD - Department of Pediatrics, Guang'anmen Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing, P. R. China. LA - eng GR - CI2020A02509/CACMS Innovation Fund/ GR - 49425/China Center for Evidence-Based Traditional Chinese Medicine/ PT - Journal Article PL - Switzerland TA - Chem Biodivers JT - Chemistry & biodiversity JID - 101197449 RN - 0 (Drugs, Chinese Herbal) RN - 0 (PPAR gamma) RN - 0 (STAT3 Transcription Factor) RN - 0 (Xiexin decoction) RN - 0 (Anti-Obesity Agents) SB - IM MH - Animals MH - *Obesity/drug therapy/metabolism MH - *Drugs, Chinese Herbal/pharmacology/chemistry/therapeutic use MH - *PPAR gamma/metabolism/antagonists & inhibitors MH - *STAT3 Transcription Factor/metabolism/antagonists & inhibitors MH - Rats MH - Molecular Docking Simulation MH - Male MH - Rats, Sprague-Dawley MH - Network Pharmacology MH - *Anti-Obesity Agents/pharmacology/chemistry MH - Diet, High-Fat PMC - PMC13420250 OTO - NOTNLM OT - DHXD OT - lipogenesis OT - lipolysis OT - molecular docking OT - obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/01/26 06:26 MHDA- 2026/01/26 06:27 PMCR- 2026/07/30 CRDT- 2026/01/26 04:13 PHST- 2025/11/13 00:00 [revised] PHST- 2025/05/28 00:00 [received] PHST- 2025/12/18 00:00 [accepted] PHST- 2026/01/26 06:27 [medline] PHST- 2026/01/26 06:26 [pubmed] PHST- 2026/01/26 04:13 [entrez] PHST- 2026/07/30 00:00 [pmc-release] AID - CBDV70861 [pii] AID - 10.1002/cbdv.202501831 [doi] PST - ppublish SO - Chem Biodivers. 2026 Jan;23(1):e01831. doi: 10.1002/cbdv.202501831. PMID- 41582709 OWN - NLM STAT- Publisher LR - 20260126 IS - 1433-7347 (Electronic) IS - 0942-2056 (Linking) DP - 2026 Jan 26 TI - Steeper posterior tibial slope increases the risk of anterior cruciate ligament rupture in a paediatric population. LID - 10.1002/ksa.70277 [doi] AB - PURPOSE: To determine whether posterior tibial slope (PTS) represents an independent risk factor for anterior cruciate ligament (ACL) rupture and to explore its association with concomitant intra-articular injuries within the ACL-injured group in a paediatric population. METHODS: A retrospective case-control study was conducted, including 190 children (mean age 13.9 +/- 1.9 years) with ACL reconstruction and 162 children (mean age 13.6 +/- 1.7 years) undergoing medial patellofemoral ligament reconstruction as controls. PTS was measured on standard lateral radiographs and sagittal magnetic resonance imaging (MRI) using the two-circle method. Measurements were performed independently by two blinded raters. Interrater reliability was assessed with the intraclass correlation coefficient (ICC). Univariate and multivariate logistic regression analyses were performed to determine associations between PTS and ACL rupture. RESULTS: On radiographs, ACL-injured patients demonstrated a significantly steeper medial PTS (MPTS) compared with controls (9.9 degrees +/- 3.1 degrees vs. 7.8 degrees +/- 4.3 degrees , p < 0.001). Similar findings were observed on MRI (8.4 degrees +/- 2.8 degrees vs. 5.0 degrees +/- 3.5 degrees , p < 0.001). Interrater reliability was excellent for both modalities (ICC > 0.90). Multivariate analysis confirmed PTS as an independent predictor of ACL rupture: each additional 1 degrees increase in MPTS was associated with a 14% higher odds of ACL injury (odds ratio [OR] 1.14, 95% confidence interval [CI]: 1.08-1.21, p < 0.001). Age, sex and body mass index were not significantly associated with ACL rupture. CONCLUSIONS: High MPTS is an independent anatomical risk factor for ACL rupture in children. Systematic measurement of PTS on radiographs or MRI should be considered during the evaluation of paediatric ACL injuries. Surgeons should be aware that children with a steep PTS may require more individualized surgical planning and follow-up. LEVEL OF EVIDENCE: Level III. CI - (c) 2026 European Society of Sports Traumatology, Knee Surgery and Arthroscopy. FAU - Piercecchi, Antoine AU - Piercecchi A AUID- ORCID: 0009-0008-7844-0117 AD - Department of Orthopedic Surgery, Institute for Locomotion, Aix-Marseille University, Marseille, France. AD - Department of Biomechanics, Institute for Locomotion, APHM, CNRS, ISM, St Marguerite Hospital, Aix-Marseille University, Marseille, France. FAU - Chaal, Lyes AU - Chaal L AD - Department of Orthopedic Surgery, Institute for Locomotion, Aix-Marseille University, Marseille, France. AD - Department of Biomechanics, Institute for Locomotion, APHM, CNRS, ISM, St Marguerite Hospital, Aix-Marseille University, Marseille, France. FAU - Druel, Julien AU - Druel J AD - Department of Orthopedic Surgery, Institute for Locomotion, Aix-Marseille University, Marseille, France. AD - Department of Biomechanics, Institute for Locomotion, APHM, CNRS, ISM, St Marguerite Hospital, Aix-Marseille University, Marseille, France. FAU - Patel, Romir AU - Patel R AD - Department of Biomechanics, Institute for Locomotion, APHM, CNRS, ISM, St Marguerite Hospital, Aix-Marseille University, Marseille, France. FAU - Peufly, Clemence AU - Peufly C AD - Department of Orthopedic Surgery, Institute for Locomotion, Aix-Marseille University, Marseille, France. AD - Department of Biomechanics, Institute for Locomotion, APHM, CNRS, ISM, St Marguerite Hospital, Aix-Marseille University, Marseille, France. FAU - Chouffani, Elie AU - Chouffani E AD - Department of Orthopedic Surgery, Institute for Locomotion, Aix-Marseille University, Marseille, France. AD - Department of Biomechanics, Institute for Locomotion, APHM, CNRS, ISM, St Marguerite Hospital, Aix-Marseille University, Marseille, France. FAU - Pesenti, Sebastien AU - Pesenti S AD - Department of Orthopedic Surgery, Institute for Locomotion, Aix-Marseille University, Marseille, France. AD - Department of Biomechanics, Institute for Locomotion, APHM, CNRS, ISM, St Marguerite Hospital, Aix-Marseille University, Marseille, France. FAU - Ollivier, Matthieu AU - Ollivier M AD - Department of Orthopedic Surgery, Institute for Locomotion, Aix-Marseille University, Marseille, France. AD - Department of Biomechanics, Institute for Locomotion, APHM, CNRS, ISM, St Marguerite Hospital, Aix-Marseille University, Marseille, France. LA - eng PT - Journal Article DEP - 20260126 PL - Germany TA - Knee Surg Sports Traumatol Arthrosc JT - Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA JID - 9314730 SB - IM OTO - NOTNLM OT - anterior cruciate ligament OT - meniscus OT - paediatric OT - posterior tibial slope OT - risk factor OT - skeletally immature EDAT- 2026/01/26 06:27 MHDA- 2026/01/26 06:27 CRDT- 2026/01/26 03:43 PHST- 2025/12/12 00:00 [revised] PHST- 2025/09/28 00:00 [received] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/01/26 06:27 [medline] PHST- 2026/01/26 06:27 [pubmed] PHST- 2026/01/26 03:43 [entrez] AID - 10.1002/ksa.70277 [doi] PST - aheadofprint SO - Knee Surg Sports Traumatol Arthrosc. 2026 Jan 26. doi: 10.1002/ksa.70277. PMID- 41582372 OWN - NLM STAT- Publisher LR - 20260126 IS - 1873-4294 (Electronic) IS - 1568-0266 (Linking) DP - 2026 Jan 15 TI - A Review on Gamma-Oryzanol as a Multitarget Therapeutic Agent for Metabolic Syndrome: Mechanisms, Preclinical Evidence, and Clinical Prospects. LID - 10.2174/0115680266379551251128092015 [doi] AB - Metabolic syndrome (MetS) is a multifactorial disorder characterized by central obesity, insulin resistance, dyslipidemia, and hypertension, which collectively increase the risk of type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), and non-alcoholic fatty liver disease (NAFLD). Due to the growing global burden of MetS, there is increasing interest in nutraceuticals such as gamma-oryzanol (gamma-ORY), a bioactive compound derived from rice bran oil (RBO), as potential therapeutic agents. A systematic literature search was conducted through July 2024 using PubMed, Google Scholar, and SciFinder. The keyword "gamma-oryzanol" was combined with terms related to MetS and its components. Original preclinical and clinical studies were included, while reviews and book chapters were excluded; however, their references were screened for additional relevant studies. Preclinical studies indicate that gamma-ORY targets multiple molecular pathways, including activation of AMP-activated protein kinase, upregulation of peroxisome proliferatoractivated receptor-alpha, inhibition of nuclear factor-kappaB, and promotion of glucose transporter type 4 translocation. These mechanisms collectively improve glucose and lipid metabolism, enhance insulin sensitivity, and reduce inflammation. Clinical trials, primarily involving adults with T2DM, obesity, dyslipidemia, or postmenopausal women (aged 30-70 years, mixed ethnicities), report that gamma-ORY reduces total cholesterol (10-15%), LDL-C (8-12%), triglycerides (10-18%), fasting glucose (10-25 mg/dL), and HbA1c (0.3-0.8%). Compared to conventional therapies such as statins (LDL-C reduction: 30-50%) or antihypertensives (e.g., irbesartan), gamma-ORY demonstrates milder efficacy but better tolerability, and may enhance the antihypertensive effects of irbesartan. Notably, clinical studies consistently report a favorable safety profile for gamma-ORY, with minimal adverse effects and no major safety concerns to date. Overall, gamma-ORY shows promise as a safe, multitarget nutraceutical for MetS management, with antioxidant, anti-inflammatory, and lipid-lowering properties. However, the generalizability of current findings is limited by small sample sizes, inconsistent dosing regimens, and underrepresentation of diverse populations (e.g., various ethnic groups and pediatric cohorts). Large-scale, well-designed clinical trials are needed to validate its efficacy, optimize dosing, and assess long-term safety compared to standard therapies. CI - Copyright(c) Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. FAU - Dutta, Partha Pratim AU - Dutta PP AD - Faculty of Pharmaceutical Science, Assam Down Town University, Panikhaiti, Guwahati, Assam, 781026, India. FAU - Saikia, Lunasmrita AU - Saikia L AD - Faculty of Pharmaceutical Science, Assam Down Town University, Panikhaiti, Guwahati, Assam, 781026, India. FAU - Law, Douglas AU - Law D AD - Faculty of Health and Life Sciences, Inti International University, 71800, Nilai, Negeri Sembilan, Malaysia. FAU - Kuppusamy, Sandhanam AU - Kuppusamy S AD - Department of Pharmacology, KMCH College of Pharmacy, Coimbatore-641048, Tamil Nadu, India. FAU - Kalita, Pratap AU - Kalita P AD - Pratiksha Institute of Pharmaceutical Sciences, Guwahati-781026, Assam, India. LA - eng PT - Journal Article DEP - 20260115 PL - United Arab Emirates TA - Curr Top Med Chem JT - Current topics in medicinal chemistry JID - 101119673 SB - IM OTO - NOTNLM OT - AMPK. OT - Adiponectin OT - Dyslipidemia OT - Gamma-oryzanol OT - Hypertension OT - Insulin resistance OT - Metabolic syndrome OT - Nutraceuticals OT - PPAR-alpha OT - Rice bran oil EDAT- 2026/01/26 06:27 MHDA- 2026/01/26 06:27 CRDT- 2026/01/26 00:13 PHST- 2025/01/19 00:00 [received] PHST- 2025/06/21 00:00 [revised] PHST- 2025/06/25 00:00 [accepted] PHST- 2026/01/26 06:27 [medline] PHST- 2026/01/26 06:27 [pubmed] PHST- 2026/01/26 00:13 [entrez] AID - CTMC-EPUB-152700 [pii] AID - 10.2174/0115680266379551251128092015 [doi] PST - aheadofprint SO - Curr Top Med Chem. 2026 Jan 15. doi: 10.2174/0115680266379551251128092015. PMID- 41582008 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260630 IS - 1476-4954 (Electronic) IS - 1476-4954 (Linking) VI - 39 IP - 1 DP - 2026 Dec TI - Baseline serum AMH‑to‑FSH ratio, menstrual pattern, and risk of intra‑uterine adhesion recurrence: a prospective multi‑state Markov model study. PG - 2606539 LID - 10.1080/14767058.2025.2606539 [doi] AB - BACKGROUND: Intra-uterine adhesion (IUA) frequently recurs after hysteroscopic adhesiolysis, undermining menstruation and fertility. We aimed to determine whether baseline serum anti‑Mullerian hormone (AMH)‑to-follicle‑stimulating hormone (FSH) ratio and menstrual pattern independently and jointly predict IUA severity transitions after adhesiolysis using a multi‑state Markov model. METHODS: We conducted a single-center prospective study of 210 women (18-45 years) undergoing first adhesiolysis for moderate-to-severe IUA. Baseline serum AMH and FSH were measured and menstrual pattern was classified as normal, hypomenorrhea, or amenorrhea. Hysteroscopy at 3, 6, 12, and 24 months defined four severity states (none, mild, moderate, severe) and two absorbing outcomes (pregnancy >/= 12 weeks, repeat surgery). Continuous-time multi-state Markov models estimated transition-specific adjusted hazard ratios (HRs) with 95% confidence intervals (CIs), controlling for age, body-mass index (BMI), baseline adhesion severity, and adjuvant therapy. Internal validation used 200-bootstrap c-index and calibration. RESULTS: Of 210 participants, 83 women (39.5%) had any recurrence and 28 (13.3%) progressed to severe adhesions. Pregnancy >/= 12 weeks occurred in 54 (25.7%) and repeat surgery in 36 (17.1%). Each one-standard-deviation decrease in AMH/FSH increased hazards from mild to moderate (adjusted HR 1.81, 95% CI 1.29-2.54) and from moderate to severe (HR 2.15, 95% CI 1.41-3.28), with a non-significant trend from none to mild (HR 1.20, 95% CI 0.95-1.52). Amenorrhea versus normal was associated with higher hazards for none to mild (HR 1.88, 95% CI 1.23-2.99) and mild to moderate (HR 1.55, 95% CI 1.10-2.18). An interaction suggested that amenorrhea amplified the adverse effect of a low AMH/FSH ratio on progression to severe disease (HR 1.39, 95% CI 1.03-1.88). The model showed good performance, with bootstrap‑corrected C‑index 0.78 (95% CI 0.74-0.82), optimism‑corrected C‑index 0.76, and optimism‑corrected calibration slope 0.94. CONCLUSIONS: Baseline endocrine status summarized by the AMH/FSH ratio and menstrual pattern independently and jointly predict IUA dynamics after adhesiolysis. A biomarker-based, multi-state risk tool may help personalize severity-anchored surveillance and re-intervention after adhesiolysis. FAU - Li, Jiying AU - Li J AD - Department of Gynecology, The Third People's Hospital of Yunnan Province, Kunming, Yunnan, China. FAU - Yan, Jin AU - Yan J AD - Department of Reproductive Medicine, Kunming Medical University Second Affiliated Hospital, Kunming, Yunnan, China. FAU - Hu, Hongwen AU - Hu H AD - Department of Gynecology, The Third People's Hospital of Yunnan Province, Kunming, Yunnan, China. FAU - Li, Yin AU - Li Y AD - Department of Gynecology, The Third People's Hospital of Yunnan Province, Kunming, Yunnan, China. FAU - Yang, Xiao AU - Yang X AD - Department of Gynecology, The Third People's Hospital of Yunnan Province, Kunming, Yunnan, China. FAU - Dong, Chaoyu AU - Dong C AD - Department of Gynecology, The Third People's Hospital of Yunnan Province, Kunming, Yunnan, China. FAU - Guo, Ziyu AU - Guo Z AD - Department of Gynecology, The Third People's Hospital of Yunnan Province, Kunming, Yunnan, China. FAU - Shen, Huanhuan AU - Shen H AD - Department of Gynecology, The Third People's Hospital of Yunnan Province, Kunming, Yunnan, China. LA - eng PT - Journal Article DEP - 20260125 PL - England TA - J Matern Fetal Neonatal Med JT - The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians JID - 101136916 RN - 80497-65-0 (Anti-Mullerian Hormone) RN - 9002-68-0 (Follicle Stimulating Hormone) SB - IM MH - Humans MH - Female MH - Tissue Adhesions/blood/surgery MH - Adult MH - Prospective Studies MH - *Anti-Mullerian Hormone/blood MH - Markov Chains MH - Recurrence MH - *Follicle Stimulating Hormone/blood MH - Young Adult MH - Adolescent MH - *Uterine Diseases/blood/surgery MH - Middle Aged MH - Pregnancy MH - Hysteroscopy/adverse effects MH - Menstruation OTO - NOTNLM OT - AMH/FSH ratio OT - Asherman syndrome OT - Intra-uterine adhesion OT - menstrual pattern OT - multi-state Markov model EDAT- 2026/01/26 00:33 MHDA- 2026/01/26 00:34 CRDT- 2026/01/25 21:32 PHST- 2026/01/26 00:34 [medline] PHST- 2026/01/26 00:33 [pubmed] PHST- 2026/01/25 21:32 [entrez] AID - 10.1080/14767058.2025.2606539 [doi] PST - ppublish SO - J Matern Fetal Neonatal Med. 2026 Dec;39(1):2606539. doi: 10.1080/14767058.2025.2606539. Epub 2026 Jan 25. PMID- 41581003 OWN - NLM STAT- MEDLINE DCOM- 20260609 LR - 20260609 IS - 1099-0968 (Electronic) IS - 1072-4133 (Linking) VI - 34 IP - 4 DP - 2026 Jul TI - Early Response to an Integrated Family and Adolescent-Focussed Treatment for Anorexia Nervosa and Atypical Anorexia Nervosa. PG - 946-951 LID - 10.1002/erv.70085 [doi] AB - OBJECTIVE: Recovery rates for adolescent anorexia nervosa (AN) remain poor, requiring creativity within the field to explore alternative treatment options. One novel, evidence-informed approach integrates both family/parent and individual adolescent-focussed treatment components, through an individualised developmental lens. This study aimed to offer preliminary insights on early response to Adolescent and Parent Treatment (APT) in terms of 8-week weight trajectory. METHOD: A naturalistic, repeated measures design was employed. Twenty-four adolescents with AN or atypical AN receiving APT as standard care were identified from a specialist private outpatient clinic. Anthropometrics and psychometrics were collected at baseline, with repeat anthropometrics 8-week later. RESULTS: A significant increase in weight was found from baseline to 8-week follow-up (2.57 kg; p < 0.001), with a large effect size (d = 1.22). No associations were found between baseline clinical features and degree of weight recovery. CONCLUSIONS: This small, exploratory study provides preliminary support for meaningful early weight recovery in APT, at a similar trajectory to that found in current first line treatment. This suggests little consequence to early weight recovery goals when integrating individual psychological support with the adolescent alongside parent-lead re-feeding, from the start of treatment. Further empirical investigation of the treatment package is indicated. CI - (c) 2026 The Author(s). European Eating Disorders Review published by Eating Disorders Association and John Wiley & Sons Ltd. FAU - Roberts, Marion E AU - Roberts ME AD - Department of General Practice & Primary Healthcare, Faculty of Medical & Health Sciences, The University of Auckland, Auckland, New Zealand. FAU - Brandeis, Sarah L AU - Brandeis SL AD - Department of General Practice & Primary Healthcare, Faculty of Medical & Health Sciences, The University of Auckland, Auckland, New Zealand. LA - eng PT - Journal Article DEP - 20260125 PL - England TA - Eur Eat Disord Rev JT - European eating disorders review : the journal of the Eating Disorders Association JID - 9436977 SB - IM MH - Humans MH - *Anorexia Nervosa/therapy/psychology MH - Adolescent MH - Female MH - *Family Therapy/methods MH - Treatment Outcome MH - Male MH - Parents/psychology EDAT- 2026/01/25 08:56 MHDA- 2026/06/10 06:54 CRDT- 2026/01/25 05:22 PHST- 2026/01/09 00:00 [revised] PHST- 2025/10/13 00:00 [received] PHST- 2026/01/17 00:00 [accepted] PHST- 2026/06/10 06:54 [medline] PHST- 2026/01/25 08:56 [pubmed] PHST- 2026/01/25 05:22 [entrez] AID - 10.1002/erv.70085 [doi] PST - ppublish SO - Eur Eat Disord Rev. 2026 Jul;34(4):946-951. doi: 10.1002/erv.70085. Epub 2026 Jan 25. PMID- 41580753 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260813 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 26 IP - 1 DP - 2026 Jan 24 TI - Immune-metabolic dysregulation and suicide risk in adolescents with major depressive disorder: a cross-sectional study. PG - 175 LID - 10.1186/s12888-025-07751-x [doi] LID - 175 AB - BACKGROUND: Biomarkers distinguishing suicidal from non-suicidal adolescents with major depressive disorder (MDD) remain elusive. This study investigated immune-metabolic dysregulation and its predictive utility for suicide attempt (SA) risk in medication-naive adolescents. METHODS: A case-control study compared 168 non-suicidal MDD adolescents with 96 MDD + SA adolescents (recent SA). Peripheral biomarkers included immune cell ratios (neutrophil/HDL [NHR], monocyte/HDL [MHR], lymphocyte/HDL [LHR]), metabolic markers (triglycerides, HDL-C, total protein (TP)), and hematological indices. Analyses employed group comparisons (t-tests/Mann-Whitney U), Spearman correlations, binary logistic regression, and ROC analysis. RESULTS: The groups were well-matched demographically and for clinical severity. After adjusting for covariates, the MDD + SA group exhibited significant immune-metabolic dysregulation, including granulocyte hyperactivity, elevated inflammatory ratios, profound HDL-C depletion, hypertriglyceridemia, and reduced total protein (all key findings with adjusted p < 0.05). A post-hoc False Discovery Rate analysis confirmed the robustness of the core lipid findings. Binary logistic regression, adjusted for age, sex, and BMI, identified triglycerides (adjusted OR = 2.17 per mmol/L) and total protein (adjusted OR = 0.93 per g/L decrease) as independent predictors of SA. A model combining triglycerides and total protein significantly outperformed individual biomarkers in ROC analysis (AUC = 0.74, 95% CI: 0.68-0.80). CONCLUSIONS: Convergent lipid-protein dysregulation represents a novel pathway for adolescent SA risk, identifiable as a significant shift within the normal laboratory range. A simple two-biomarker panel shows promise for risk stratification but requires future validation. These findings highlight metabolic dysfunction as a potential target for preventive strategies, though they do not yet constitute evidence for specific clinical interventions. CI - (c) 2025. The Author(s). FAU - Liang, Yudiao AU - Liang Y AD - Department of Psychiatry, The Affiliated Hospital of Southwest Medical University, Luzhou, China. FAU - Tan, Chengyi AU - Tan C AD - Department of Psychiatry, The Affiliated Hospital of Southwest Medical University, Luzhou, China. FAU - Liu, Ming AU - Liu M AD - Department of Psychiatry, Zigong Hospital Affiliated to Southwest Medical University, Zigong, China. FAU - Wang, Lei AU - Wang L AD - Department of Psychiatry, Zigong Hospital Affiliated to Southwest Medical University, Zigong, China. FAU - Zhang, Sha AU - Zhang S AD - Department of Psychiatry, Zigong Hospital Affiliated to Southwest Medical University, Zigong, China. FAU - Liu, Kezhi AU - Liu K AD - Department of Psychiatry, The Affiliated Hospital of Southwest Medical University, Luzhou, China. kingzliu@163.com. LA - eng PT - Journal Article DEP - 20260124 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 RN - 0 (Biomarkers) RN - 0 (Triglycerides) SB - IM MH - Humans MH - *Major Depressive Disorder/immunology/blood/psychology/metabolism MH - Adolescent MH - Female MH - Cross-Sectional Studies MH - Biomarkers/blood MH - Case-Control Studies MH - Male MH - *Suicide, Attempted/psychology MH - Triglycerides/blood PMC - PMC12911106 OTO - NOTNLM OT - Adolescent suicide OT - Biomarkers OT - Immune-metabolic dysregulation OT - Major depressive disorder OT - Predictive model OT - Total protein OT - Triglycerides COIS- Declarations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/25 00:37 MHDA- 2026/02/18 10:07 PMCR- 2026/01/24 CRDT- 2026/01/24 23:27 PHST- 2025/11/16 00:00 [received] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/02/18 10:07 [medline] PHST- 2026/01/25 00:37 [pubmed] PHST- 2026/01/24 23:27 [entrez] PHST- 2026/01/24 00:00 [pmc-release] AID - 10.1186/s12888-025-07751-x [pii] AID - 7751 [pii] AID - 10.1186/s12888-025-07751-x [doi] PST - epublish SO - BMC Psychiatry. 2026 Jan 24;26(1):175. doi: 10.1186/s12888-025-07751-x. PMID- 41580653 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260813 IS - 1471-2377 (Electronic) IS - 1471-2377 (Linking) VI - 26 IP - 1 DP - 2026 Jan 24 TI - Serum creatinine to cystatin C ratio as a biomarker for monitoring motor-function in children with spinal muscular atrophy treated with nusinersen: a retrospective cohort study. PG - 120 LID - 10.1186/s12883-026-04657-3 [doi] LID - 120 AB - OBJECTIVE: To validate the clinical utility of creatinine-to-cystatin C ratio (CCR) as a biomarker for monitoring nusinersen treatment response in Chinese paediatric patients receiving nusinersen monotherapy. METHODS: In this retrospective, single-center study, 33 genetically confirmed 5q-SMA patients (/= 26 months (2020.2-2025.6) were enrolled. Motor function was serially evaluated using the Hammersmith Functional Motor Scale Expanded (HFMSE), Revised Upper Limb Module (RULM), and Hammersmith Infant Neurological Exam Part 2 (HINE-2). Serum biomarkers, such as creatinine (Cr), creatine kinase (CK), and cystatin C, were measured at multiple time points. A linear mixed-effects model (adjusted for age, body mass index, SMA type, and treatment duration) was used to assess the biomarker-function associations. RESULTS: Ambulant patients and those with four SMN2 copies demonstrated elevated CCR and Cr levels compared to non-ambulant patients and those with three SMN2 copies at baseline. Serum CCR levels were significantly higher than the baseline at V4-V8 (10-26 months). Cr levels were significantly higher than the baseline at V8 (26 months), whereas CK and cystatin C levels remained unchanged. In the fully adjusted linear mixed-effects models, both CCR and Cr were positively associated with HFMSE and RULM scores. However, only CCR remained significant after adjustment. Cystatin C levels were inversely correlated with the HINE-2 scores. CONCLUSION: CCR is a promising biomarker in paediatric SMA patients receiving nusinersen monotherapy; however, its validity and generalizability require confirmation in larger, more diverse multicenter cohorts. CI - (c) 2026. The Author(s). FAU - Zhang, Yuan Yuan AU - Zhang YY AD - Department of Paediatrics, Affiliated Liaocheng Second People's Hospital of Shandong First Medical University, Liaocheng, Shandong Province, China. FAU - Wang, Jie AU - Wang J AD - Department of Neurology, Jinan Children's Hospital (Children's Hospital Affiliated to Shandong University), Jinan, Shandong Province, China. FAU - Cui, Zhen Qiong AU - Cui ZQ AD - Department of Neurology, Jinan Children's Hospital (Children's Hospital Affiliated to Shandong University), Jinan, Shandong Province, China. FAU - Ma, Kai AU - Ma K AD - Department of Neurology, Jinan Children's Hospital (Children's Hospital Affiliated to Shandong University), Jinan, Shandong Province, China. shdhmmk@126.com. LA - eng PT - Journal Article DEP - 20260124 PL - England TA - BMC Neurol JT - BMC neurology JID - 100968555 RN - 0 (Cystatin C) RN - 5Z9SP3X666 (nusinersen) RN - 0 (Oligonucleotides) RN - 0 (Biomarkers) RN - AYI8EX34EU (Creatinine) SB - IM MH - Humans MH - *Cystatin C/blood MH - Retrospective Studies MH - *Oligonucleotides/therapeutic use MH - Female MH - Male MH - Biomarkers/blood MH - Child MH - *Creatinine/blood MH - Child, Preschool MH - *Muscular Atrophy, Spinal/drug therapy/blood/physiopathology MH - Adolescent MH - Infant MH - Treatment Outcome MH - *Spinal Muscular Atrophies of Childhood/drug therapy/blood PMC - PMC12910726 OTO - NOTNLM OT - Children OT - Creatinine-to-cystatin C ratio OT - Nusinersen OT - Retrospective cohort study OT - Serum biomarkers OT - Spinal muscular atrophy COIS- Declarations. Ethics approval and consent to participate: This study was conducted in full compliance with the ethical principles outlined in the Helsinki Declaration. The study protocol was approved by the Ethics Committee of Jinan Children's Hospital (approval no.SDFE-IRB/T-2025105). Written informed consent was obtained from the parents or legal guardians, and assent was obtained from the children when it was developmentally appropriate. Consent for publication: The participants in this study and all authors of this article provided consent for the publication of this article. Competing interests: The authors declare no competing interests. EDAT- 2026/01/25 00:37 MHDA- 2026/02/18 10:07 PMCR- 2026/01/24 CRDT- 2026/01/24 23:24 PHST- 2025/09/04 00:00 [received] PHST- 2026/01/13 00:00 [accepted] PHST- 2026/02/18 10:07 [medline] PHST- 2026/01/25 00:37 [pubmed] PHST- 2026/01/24 23:24 [entrez] PHST- 2026/01/24 00:00 [pmc-release] AID - 10.1186/s12883-026-04657-3 [pii] AID - 4657 [pii] AID - 10.1186/s12883-026-04657-3 [doi] PST - epublish SO - BMC Neurol. 2026 Jan 24;26(1):120. doi: 10.1186/s12883-026-04657-3. PMID- 41580572 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20261010 IS - 1432-198X (Electronic) IS - 0931-041X (Linking) VI - 41 IP - 6 DP - 2026 Jun TI - m-Health-based exercise program among children and adolescents with chronic kidney disease: a feasibility study. PG - 1811-1820 LID - 10.1007/s00467-026-07155-3 [doi] AB - BACKGROUND: Children and adolescents with chronic kidney disease (CKD) often exhibit reduced physical fitness due to physical inactivity, fatigue, and muscle weakness. Despite the exercise benefits, participation remains limited due to barriers such as limited access, inadequate resources, and poor motivation. The m-Health platform may provide an adaptable strategy to address these challenges. Hence, this study aimed to assess the feasibility of the m-Health-based exercise program among the pediatric CKD population. METHODS: Thirty children and adolescents with CKD stages 3-5, aged 6-18 years, were enrolled in a 4-week m-Health-based exercise program. Feasibility was evaluated through adherence, usability, satisfaction, and semi-structured telephonic interviews with participants and caregivers. Functional outcomes included the 6-min walk test (6-MWT) and hand grip strength (HGS). Adherence, usability, and satisfaction data were summarized using descriptive statistics. Thematic analysis was used to represent the qualitative data. Pre- and post-intervention 6-MWT and HGS values were compared using paired t-tests. RESULTS: Twenty-seven participants completed the study. Adherence to the m-Health exercise program was low, with 18.5% meeting the criteria. However, 51.8% reported excellent usability, and satisfaction was reported by 70.3% of parents and 62.9% of participants. Qualitative data highlighted three key aspects-alternative exercise practices, perceived exercise benefits, and multifaceted barriers. Participants demonstrated significant improvements in their functional outcomes post-intervention (6-MWT, 48.8 m, p < 0.001; HGS, 0.7 kg, p = 0.021). CONCLUSIONS: Despite low adherence, the m-Health-based exercise program served as a motivating stimulus for promoting physical activity and facilitating positive behavior change among children and adolescents with CKD. CTRI REGISTRATION: This study was registered with the Clinical Trials Registry of India (CTRI) on 20-11-2024 under registration number CTRI/2024/11/077131. CI - (c) 2026. The Author(s), under exclusive licence to International Pediatric Nephrology Association. FAU - Miskin, Swati Arun AU - Miskin SA AUID- ORCID: 0009-0000-1769-0149 AD - M. S. Ramaiah College of Physiotherapy, M. S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India. FAU - V, Hamsa AU - V H AUID- ORCID: 0000-0002-8984-2479 AD - Pediatric Nephrology, Department of Pediatrics Nephrology , M. S. Ramaiah Medical College, M. S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India. FAU - Naaz, Nikhat AU - Naaz N AUID- ORCID: 0009-0002-4836-4746 AD - M. S. Ramaiah College of Physiotherapy, M. S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India. FAU - Alva, Rajitha AU - Alva R AUID- ORCID: 0000-0001-6460-0337 AD - M. S. Ramaiah College of Physiotherapy, M. S. Ramaiah University of Applied Sciences, Bengaluru, Karnataka, India. alvarajju@gmail.com. LA - eng PT - Journal Article DEP - 20260124 PL - Germany TA - Pediatr Nephrol JT - Pediatric nephrology (Berlin, Germany) JID - 8708728 SB - IM MH - Humans MH - Child MH - Adolescent MH - Female MH - Feasibility Studies MH - Male MH - *Renal Insufficiency, Chronic/therapy/rehabilitation/physiopathology/psychology MH - *Exercise Therapy/methods MH - Hand Strength MH - Patient Compliance/statistics & numerical data MH - Physical Fitness MH - Walk Test MH - Patient Satisfaction/statistics & numerical data MH - Telemedicine OTO - NOTNLM OT - Chronic Kidney Disease OT - Pediatrics OT - Digital Health OT - Exercise COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. The study was approved by the M. S. Ramaiah Medical College Institutional Ethical Committee (MSRMC/EC/PG-18/08-2024). Consent to participate: Written informed consent from the parents, and assent from from the participants were obtained. Verbal informed consent was obtained prior to the interview. Competing interests: The authors declare no competing interests. EQUATOR network reporting guidelines: The manuscript has been prepared in accordance with CONSORT 2010: extension to Pilot and Feasibility Studies. Permission: Permission to cite PhysiApp was obtained from the company, and the associated subscription fees for its use were paid by the primary author. EDAT- 2026/01/25 00:37 MHDA- 2026/05/04 12:34 CRDT- 2026/01/24 23:17 PHST- 2025/10/11 00:00 [received] PHST- 2026/01/07 00:00 [accepted] PHST- 2025/12/05 00:00 [revised] PHST- 2026/05/04 12:34 [medline] PHST- 2026/01/25 00:37 [pubmed] PHST- 2026/01/24 23:17 [entrez] AID - 10.1007/s00467-026-07155-3 [pii] AID - 10.1007/s00467-026-07155-3 [doi] PST - ppublish SO - Pediatr Nephrol. 2026 Jun;41(6):1811-1820. doi: 10.1007/s00467-026-07155-3. Epub 2026 Jan 24. PMID- 41579526 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260730 IS - 1532-8171 (Electronic) IS - 0735-6757 (Linking) VI - 102 DP - 2026 Apr TI - A global perspective on the accuracy of pediatric weight estimation methods in emergency care: A systematic review. PG - 81-89 LID - S0735-6757(26)00039-2 [pii] LID - 10.1016/j.ajem.2026.01.030 [doi] AB - INTRODUCTION: In pediatric emergency services, it is essential to know the patient's weight, for which there are numerous estimation tools. However, these instruments present biases in calculating the patient's weight. Therefore, the objective of this study was to evaluate the validity of pediatric weight estimation methods available worldwide, comparing their accuracy and applicability in medical practice. METHODS: A systematic review was conducted following the PRISMA recommendations (PROSPERO Registration Number CRD420251174686). Observational and validation studies with original data published from 2010 to July 2025 were included. Articles were searched for in ProQuest, Web of Science, PubMed/Medline, and Scopus. The inclusion criteria were: patients aged 0 to 18 years, weight estimation methods, and quantitative reports of accuracy. RESULTS: Thirty-one studies from all continents were selected. Two-dimensional methods were generally more accurate than those based solely on age or one-dimensional formulas, especially in populations with a high prevalence of overweight or obesity. Parental estimation also performed well. Heterogeneity was observed in age ranges, acceptable error and validation criteria between studies. CONCLUSIONS: Within the limitations of the uneven global evidence base, the tools that appear most reliable for estimating pediatric weight in emergency departments are those that incorporate more than one anthropometric variable or are supported by local validation. Given the scarcity of data from various regions and specific populations, each emergency system must determine the approach that best suits its local demographic profile, invest in staff training, and apply standardized validation criteria before adopting changes in routine practice. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Inc. All rights reserved. FAU - Fernandez-Aedo, Irrintzi AU - Fernandez-Aedo I AD - Biobizkaia Health Research Institute (IIS Biobizkaia), Plaza de Cruces s/n, Barakaldo, Bizkaia 48903, Spain; Nursing I department, Faculty of Medicine and Nursing, University of the Basque Country (EHU), Spain. FAU - Ballesteros-Pena, Sendoa AU - Ballesteros-Pena S AD - Biobizkaia Health Research Institute (IIS Biobizkaia), Plaza de Cruces s/n, Barakaldo, Bizkaia 48903, Spain; Nursing I department, Faculty of Medicine and Nursing, University of the Basque Country (EHU), Spain; Hospital Santa Marina, Osakidetza - Basque Health Service, Carretera Santa Marina 41, Bilbao, Bizkaia 48004, Spain. FAU - Tobar-Cabrera, Sandra AU - Tobar-Cabrera S AD - Nursing department, Faculty of Health Sciences, University of Tarapaca, Iquique, Chile. FAU - Vallejo-De la Hoz, Gorka AU - Vallejo-De la Hoz G AD - Biobizkaia Health Research Institute (IIS Biobizkaia), Plaza de Cruces s/n, Barakaldo, Bizkaia 48903, Spain; Nursing I department, Faculty of Medicine and Nursing, University of the Basque Country (EHU), Spain; Hospital Universitario Galdakao-Usansolo, Osakidetza - Basque Health Service, Barrio Labeaga 46-A, Galdakao, Bizkaia 48960, Spain. FAU - Fernandez-Alonso, Julia AU - Fernandez-Alonso J AD - Biobizkaia Health Research Institute (IIS Biobizkaia), Plaza de Cruces s/n, Barakaldo, Bizkaia 48903, Spain; Physiology department, Faculty of Medicine and Nursing, University of the Basque Country (EHU), Spain. Electronic address: Julia.fernandez@ehu.eus. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260120 PL - United States TA - Am J Emerg Med JT - The American journal of emergency medicine JID - 8309942 SB - IM MH - Humans MH - Child MH - *Body Weight MH - *Emergency Service, Hospital MH - Child, Preschool MH - Infant MH - *Anthropometry/methods MH - Adolescent MH - *Emergency Medical Services MH - Reproducibility of Results MH - Infant, Newborn OTO - NOTNLM OT - Anthropometry OT - Body weight OT - Emergency medicine OT - Pediatrics COIS- Declaration of competing interest None. EDAT- 2026/01/25 00:37 MHDA- 2026/02/22 05:35 CRDT- 2026/01/24 18:04 PHST- 2025/11/08 00:00 [received] PHST- 2025/12/10 00:00 [revised] PHST- 2026/01/17 00:00 [accepted] PHST- 2026/02/22 05:35 [medline] PHST- 2026/01/25 00:37 [pubmed] PHST- 2026/01/24 18:04 [entrez] AID - S0735-6757(26)00039-2 [pii] AID - 10.1016/j.ajem.2026.01.030 [doi] PST - ppublish SO - Am J Emerg Med. 2026 Apr;102:81-89. doi: 10.1016/j.ajem.2026.01.030. Epub 2026 Jan 20. PMID- 41578976 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260926 IS - 1541-4337 (Electronic) IS - 1541-4337 (Linking) VI - 25 IP - 1 DP - 2026 Jan TI - Quality Analysis and Detection of Adulterants and Contaminations in Milk/Milk Powder by Raman Spectroscopy. PG - e70403 LID - 10.1111/1541-4337.70403 [doi] LID - e70403 AB - Milk and milk powder are central to global nutrition, yet remain vulnerable to adulteration and contamination. Adulteration using water, urea, ammonium sulfate, thiocyanates, detergents, melamine, or compositional changes with whey and carbohydrate fillers undermines nutritional quality, reduces consumer confidence, and challenges regulatory control, particularly in infant formula products. A field-ready analytical platform that is rapid, nondestructive, and capable of multi-adulterant surveillance is urgently needed across diverse dairy matrices. This review consolidates advances in Raman spectroscopy for milk and milk powder authentication reported from 2015 to early 2025, covering conventional Raman, surface-enhanced Raman spectroscopy (SERS), Fourier-transform Raman, hyperspectral Raman imaging, confocal/mapping approaches, and portable systems. We critically evaluate preprocessing and chemometrics such as principal component analysis, partial least squares regression, and partial least squares discriminant analysis, as well as machine-learning and deep-learning pipelines for classification and quantification. Species-specific applications including cow, buffalo, goat, camel, donkey, human breast milk (macronutrients, sex-linked profiles, microplastics, antibiotics), and milk powder workflows are compared with attention to matrix effects, fluorescence interference, and validation practices. Raman enables chemically specific fingerprints of proteins, lipids, and carbohydrates, whereas common adulterants present diagnostic bands. SERS substrates routinely extend sensitivity to ppm-ppb levels and suppress fluorescence, supporting rapid detection of melamine, urea, ammonium sulfate, thiocyanates, benzoate, and selected antibiotics. Hyperspectral imaging provides spatially resolved maps, differentiating multi-adulterant mixtures and thermo-structural behavior in powders. Chemometric models achieve high accuracy for classification and concentration prediction, whereas deep-learning architectures improve robustness under nonlinear matrix variation and instrument drift. Challenges persist in substrate reproducibility, calibration transfer, fluorescence in lipid-rich systems, and detection of emerging adulterants and trace preservatives under field conditions. Future progress will hinge on multi-excitation instruments with adaptive laser power control, universal SERS substrates integrating plasmonic metals, dielectric shells, and molecular recognition, and standard operating procedure grade preprocessing. Industrial reliability requires calibration-transfer strategies, rigorous validation, and explainable artificial intelligence to link decisions to chemically meaningful features, supporting regulatory acceptance and auditability. Portable Raman and SERS systems can aid nutritional profiling and contaminant surveillance in breast milk, whereas Fourier-transform Raman and hyperspectral imaging mitigate fluorescence and map heterogeneity in powders. Raman spectroscopy, augmented by SERS, hyperspectral imaging, and intelligent analytics, offers a rapid, nondestructive, label-free, and scalable platform for dairy authentication. Continued innovation will enable real-time, on-site detection of single and multiple adulterants, strengthening consumer confidence, industrial quality assurance, and regulatory compliance while advancing global food safety. CI - (c) 2026 The Author(s). Comprehensive Reviews in Food Science and Food Safety published by Wiley Periodicals LLC on behalf of Institute of Food Technologists. FAU - Acharya, B Sudarshan AU - Acharya BS AD - Manipal Institute of Applied Physics, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka, India. FAU - Nair, Sreerag AU - Nair S AD - Manipal Institute of Applied Physics, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka, India. FAU - Abdul Salam, Abdul Ajees AU - Abdul Salam AA AUID- ORCID: 0000-0002-3377-3048 AD - Manipal Institute of Applied Physics, Manipal Academy of Higher Education, Manipal, Udupi, Karnataka, India. LA - eng GR - Manipal Academy of Higher Education (MAHE)/ PT - Journal Article PT - Review PL - United States TA - Compr Rev Food Sci Food Saf JT - Comprehensive reviews in food science and food safety JID - 101305205 RN - 0 (Powders) SB - IM MH - *Spectrum Analysis, Raman/methods MH - Animals MH - *Milk/chemistry MH - *Food Contamination/analysis MH - Humans MH - Powders MH - Infant Formula/chemistry PMC - PMC12831472 OTO - NOTNLM OT - Raman spectroscopy OT - calibration transfer OT - chemometrics OT - dairy authentication OT - explainable artificial intelligence OT - food safety OT - hyperspectral Raman imaging OT - milk adulteration OT - portable sensors OT - surface-enhanced Raman spectroscopy COIS- The authors declare no conflicts of interest. EDAT- 2026/01/24 12:32 MHDA- 2026/01/24 12:33 PMCR- 2026/01/24 CRDT- 2026/01/24 08:12 PHST- 2025/12/26 00:00 [revised] PHST- 2025/07/03 00:00 [received] PHST- 2025/12/31 00:00 [accepted] PHST- 2026/01/24 12:33 [medline] PHST- 2026/01/24 12:32 [pubmed] PHST- 2026/01/24 08:12 [entrez] PHST- 2026/01/24 00:00 [pmc-release] AID - CRF370403 [pii] AID - 10.1111/1541-4337.70403 [doi] PST - ppublish SO - Compr Rev Food Sci Food Saf. 2026 Jan;25(1):e70403. doi: 10.1111/1541-4337.70403. PMID- 41578519 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 4 DP - 2026 Jan 23 TI - Development and validation of a logistic regression model for predicting menstrual irregularity using LDL-C and age in reproductive-aged women: An analysis of NHANES Data. PG - e46939 LID - 10.1097/MD.0000000000046939 [doi] LID - e46939 AB - Menstrual irregularity is a common reproductive endocrine disorder among women of reproductive age, serving both as an early indicator of various gynecological diseases and a potential marker of underlying metabolic disturbances. Low-density lipoprotein cholesterol (LDL-C), a key indicator of lipid metabolism, lacks robust epidemiological evidence regarding its association with menstrual irregularity. This study utilized data from the 2013 to 2014 cycle of the National Health and Nutrition Examination Survey, which included (n = 623) women aged 15 to 49 years, to train a logistic regression model for assessing the association between LDL-C levels and menstrual irregularity. The model was externally validated using data from the 2009 to 2010 cycle (n = 799). Model performance was evaluated using the area under the receiver operating characteristic curve (area under the curve [AUC]), calibration plots, and confusion matrices. A nomogram was constructed to enhance clinical interpretability. The analysis indicated that LDL-C levels and age were significant predictors of menstrual irregularity. The AUCs of the model were 0.754 in the training set and 0.765 in the validation set, demonstrating good predictive performance and robustness. Residual analysis and collinearity diagnostics further supported the good fit of the model. The nomogram based on the final model enables visualized assessment of individual risk, aiding clinical risk stratification and decision-making. Elevated LDL-C levels are significantly associated with menstrual irregularity in women of reproductive age, suggesting its potential role as a metabolic biomarker of reproductive health. Longitudinal studies are recommended to clarify the causal relationship and to explore the potential of lipid-lowering interventions in menstrual regulation. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Zou, Yafeng AU - Zou Y AUID- ORCID: 0009-0005-4448-5075 AD - Jiangxi University of Traditional Chinese Medicine, Nanchang, China. FAU - Peng, Jiahua AU - Peng J AUID- ORCID: 0000-0002-8741-397 AD - Institute of Gynecology and Obstetrics of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China. FAU - Li, Peishuang AU - Li P AD - Institute of Gynecology and Obstetrics of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China. AD - Department of Gynecology, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China. FAU - Xu, Ling AU - Xu L AD - The Second Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China. FAU - Peng, Xuemei AU - Peng X AD - The Second Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China. FAU - Liang, Ruining AU - Liang R AUID- ORCID: 0000-0002-8775-4918 AD - Institute of Gynecology and Obstetrics of Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China. AD - Department of Gynecology, The Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China. AD - The Second Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine, Nanchang, China. LA - eng GR - No. 20223BBG71012/Jiangxi Provincial Science and Technology Department aeurooeRevealing the Banner and Hanging the Spearaeuro Project/ PT - Journal Article PT - Validation Study PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - 0 (Cholesterol, LDL) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Adult MH - Logistic Models MH - Middle Aged MH - *Cholesterol, LDL/blood MH - *Menstruation Disturbances/blood/diagnosis/epidemiology MH - Adolescent MH - Nutrition Surveys MH - Young Adult MH - Age Factors MH - Biomarkers/blood MH - ROC Curve MH - Nomograms PMC - PMC12851681 OTO - NOTNLM OT - NHANES OT - low-density lipoprotein cholesterol OT - menstrual irregularity OT - metabolic disorders OT - reproductive health COIS- The authors have no conflicts of interest to disclose. EDAT- 2026/01/24 06:35 MHDA- 2026/01/24 06:36 PMCR- 2026/01/23 CRDT- 2026/01/24 01:02 PHST- 2025/08/17 00:00 [received] PHST- 2025/11/12 00:00 [accepted] PHST- 2026/01/24 06:36 [medline] PHST- 2026/01/24 06:35 [pubmed] PHST- 2026/01/24 01:02 [entrez] PHST- 2026/01/23 00:00 [pmc-release] AID - 00005792-202601230-00065 [pii] AID - MD-D-25-10100 [pii] AID - 10.1097/MD.0000000000046939 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jan 23;105(4):e46939. doi: 10.1097/MD.0000000000046939. PMID- 41578413 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Jan 23 TI - Effects of wrestling training on psychological well-being, anxiety, and resilience in adolescent boys. PG - 239 LID - 10.1186/s40359-026-03962-3 [doi] LID - 239 AB - BACKGROUND: Wrestling is a physically and mentally demanding combat sport that requires discipline, focus, and emotional control. Although its physiological effects are well documented, its psychological benefits in adolescents remain underexplored. This study aimed to examine whether a short-term, non-competitive wrestling program could enhance psychological well-being, reduce sport anxiety, and strengthen resilience in adolescent boys. METHODS: Thirty sedentary male adolescents (aged 12-15 years) were randomly assigned to a wrestling training group (n = 15) or a control group (n = 15). The intervention consisted of six weeks of supervised wrestling sessions performed three times per week. Psychological well-being (WHO-5), sport anxiety (SAS-2), and resilience (BPRS) were assessed before and after the intervention using the validated Turkish versions of the scales. Two-way repeated-measures ANOVA was used to analyze group x time interactions. RESULTS: Participants in the wrestling group demonstrated significant improvements in well-being (p < 0.001) and resilience (p < 0.001), alongside marked reductions in total sport anxiety and its subdimensions (p < 0.001), compared with the control group. All effects were large (etap(2) = 0.52-0.94). CONCLUSION: A structured six-week wrestling program produced meaningful psychological benefits in adolescent boys. Regular participation in non-competitive wrestling may serve as an effective approach to promote well-being, emotional stability, and adaptive coping skills during early adolescence, supporting the preventive and developmental role of combat sports in youth mental health. TRIAL REGISTRATION: Effects of wrestling training on psychological well-being, anxiety, and Resilience in Adolescent Boys. NCT07193121, Date: 12-09-2025. FAU - Ozkan, Ridvan AU - Ozkan R AD - Faculty of Sports Sciences, Kastamonu University, Kastamonu, Turkey. FAU - Yilmaz, Coskun AU - Yilmaz C AUID- ORCID: 0000-0002-2826-1566 AD - Kelkit Aydin Dogan Vocational School, Gumushane University, P.O. Box 29600, Gumushane, 24, Turkiye, Turkey. coskun.yilmaz@gumushane.edu.tr. FAU - Uzun, Recep Nur AU - Uzun RN AUID- ORCID: 0000-0002-0825-8722 AD - Yasar Dogu Faculty of Sport Sciences, Ondokuz Mayis University, Samsun, Turkey. FAU - Bayrakdaroglu, Serdar AU - Bayrakdaroglu S AUID- ORCID: 0000-0002-2166-6675 AD - Faculty of Sports Sciences, Gumushane University, Gumushane, Turkey. FAU - Akar, Ozge Orhan AU - Akar OO AD - Faculty of Sports Sciences, Kastamonu University, Kastamonu, Turkey. FAU - Oz, Faik AU - Oz F AUID- ORCID: 0009-0008-8883-2130 AD - Faculty of Sport Sciences, Avrasya University, Trabzon, Turkey. FAU - Cicekli, Atif AU - Cicekli A AD - Governorship of Amasya, Amasya, Turkey. FAU - Cicekli, Aylin AU - Cicekli A AD - Faculty of Sociology, Akdeniz University, Antalya, Turkey. FAU - Dal, Suzan AU - Dal S AUID- ORCID: 0000-0002-7732-9846 AD - Cerrahpasa Faculty of Sports Sciences, Istanbul University, Istanbul, Turkey. FAU - Ursu, Vasile Emil AU - Ursu VE AUID- ORCID: 0000-0003-2805-031X AD - Department of Physical Education and Sport, Faculty of Law and Social Sciences, University "1 Decembrie 1918" of Alba Iulia, Alba Iulia, Romania. vasile.ursu@uab.ro. FAU - Citozi, Robert AU - Citozi R AUID- ORCID: 0000-0003-3707-222X AD - Faculty of Physical Activity and Recreation, Sports University of Tirana, Tirane, Albania. FAU - Geanta, Vlad Adrian AU - Geanta VA AUID- ORCID: 0000-0002-8488-1698 AD - Department of Physical Education and Sport, Faculty of Physical Education and Sport, Aurel Vlaicu University of Arad, Arad, 310330, Romania. LA - eng SI - ClinicalTrials.gov/NCT07193121 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260123 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Male MH - *Wrestling/psychology MH - Adolescent MH - *Psychological Well-Being MH - *Resilience, Psychological MH - *Anxiety/psychology/prevention & control/therapy MH - Child PMC - PMC12911033 OTO - NOTNLM OT - Adolescents OT - Anxiety OT - Combat sports OT - Mental health OT - Psychological resilience OT - Short-term effects OT - Well-being OT - Wrestling COIS- Declarations. Ethics approval and consent to participate: The study protocol was reviewed and approved by the Ethics Committee of Gumushane University (Approval No: 2025/6, dated June 25, 2025). The research was conducted in accordance with institutional guidelines, national legislation, and the ethical principles outlined in the Declaration of Helsinki. Written informed consent was obtained from all participants and their legal guardians prior to participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/24 06:36 MHDA- 2026/06/27 06:46 PMCR- 2026/01/23 CRDT- 2026/01/24 00:08 PHST- 2025/11/30 00:00 [received] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/06/27 06:46 [medline] PHST- 2026/01/24 06:36 [pubmed] PHST- 2026/01/24 00:08 [entrez] PHST- 2026/01/23 00:00 [pmc-release] AID - 10.1186/s40359-026-03962-3 [pii] AID - 3962 [pii] AID - 10.1186/s40359-026-03962-3 [doi] PST - epublish SO - BMC Psychol. 2026 Jan 23;14(1):239. doi: 10.1186/s40359-026-03962-3. PMID- 41578367 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260130 LR - 20260131 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2026 Jan 23 TI - Eating disorders and disordered eating behaviour in older adults: a scoping review. PG - 36 LID - 10.1186/s40337-025-01486-6 [doi] LID - 36 AB - BACKGROUND: Eating disorders (ED) and disordered eating behaviours (DEB) in older adults have important implications for physical morbidity and mortality. Thus far, there has been no attempt to systematically evaluate the research landscape of ED and DEB in older adults. METHODS: A scoping review adhering to PRISMA-ScR reporting standards was conducted. We searched MEDLINE, Google Scholar, and PsycINFO (2000-2025) for English-language, peer-reviewed articles on ED/DEB in older adults covering diagnosis, epidemiology, determinants, clinical features, progression, or treatment, in any setting. RESULTS: A total of 53 publications were included in the final review, comprising four systematic reviews, five longitudinal studies, and 44 cross-sectional studies. All original studies were observational in design. Research was predominantly community-based and relied on single-step screening, limiting diagnostic validity. Healthcare facility-based studies have examined ED in patients with comorbidities such as obesity, diabetes, and those undergoing bariatric surgery. Most study participants were Caucasian, with limited representation from minority groups. ED in older adults were mostly in women, with presentations characterised by dietary restriction, binge-purge behaviours, and body image preoccupation. The data on prevalence of subtypes of ED was variably reported. Most late-onset cases were precipitated by psychosocial stressors such as bereavement, caregiving responsibilities, or social isolation. Biological factors, particularly menopausal age in women, were found to be associated with an increased prevalence of DEBs, such as binge eating and restrictive eating patterns. Comorbid depression, anxiety, and medical conditions were frequent. Combined behavioural and pharmacological interventions offered better outcomes. Poorer outcomes were linked to chronicity, low body mass index, presence of comorbidities, and poor treatment engagement. Protective factors, including cognitive adaptation and positive attitudes toward ageing, may confer resilience. CONCLUSION: ED and DEB in older adults are a significant but underrecognized public health issue. Existing research is constrained by limited diversity, Western-centric samples, and reliance on self-reported measures, underscoring the urgent need for inclusive, longitudinal, and interventional studies that better capture biopsychosocial determinants of EDs and DEBs, while also promoting the provision of age-sensitive care. CI - (c) 2026. The Author(s). FAU - Vaidyanathan, Sivapriya AU - Vaidyanathan S AUID- ORCID: 0000-0002-2793-0537 AD - Department of Psychiatry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - Purohith Narasimhan, Abhiram AU - Purohith Narasimhan A AUID- ORCID: 0000-0002-0265-2147 AD - Department of Psychiatry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - Mynampally, Keerthana AU - Mynampally K AD - Department of Psychiatry, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. FAU - Menon, Vikas AU - Menon V AUID- ORCID: 0000-0001-8035-4658 AD - Department of Psychiatry, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006, India. drvmenon@gmail.com. LA - eng PT - Journal Article PT - Review DEP - 20260123 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC12853710 OAB - Eating disorders are often thought to affect only teenagers and young adults, but research shows that they also occur in older adults. This review looked at studies published since 2000 on eating disorders and disordered eating in people aged 50 and above. We found 53 studies, but most were small and observational in design. Most participants were women, and very few studies included people from minority groups.Traditionally, eating disorders were more common in women after stressful life events such as bereavement, caregiving pressures, or social isolation. Biological changes, such as menopause also contributed to the onset. Depression, anxiety, and physical health problems frequently occurred alongside eating disorders. Treatment typically involved a combination of talking therapies and medication, with combined approaches yielding better results.Our findings show that eating disorders in older adults are an important but overlooked health issue. Greater awareness, more ethnically inclusive research, and tailored support can help older people manage these conditions and improve recovery. OABL- eng OTO - NOTNLM OT - Disordered eating OT - Eating disorders OT - Eating habits OT - Elderly OT - Geriatric OT - Late life OT - Older adults COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/24 06:35 MHDA- 2026/01/24 06:36 PMCR- 2026/01/23 CRDT- 2026/01/24 00:06 PHST- 2025/08/30 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2026/01/24 06:36 [medline] PHST- 2026/01/24 06:35 [pubmed] PHST- 2026/01/24 00:06 [entrez] PHST- 2026/01/23 00:00 [pmc-release] AID - 10.1186/s40337-025-01486-6 [pii] AID - 1486 [pii] AID - 10.1186/s40337-025-01486-6 [doi] PST - epublish SO - J Eat Disord. 2026 Jan 23;14(1):36. doi: 10.1186/s40337-025-01486-6. PMID- 41578315 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1746-4358 (Electronic) IS - 1746-4358 (Linking) VI - 21 IP - 1 DP - 2026 Jan 23 TI - Intentions, practices, and social representations regarding breastfeeding among women experiencing social disadvantage: findings from the qualitative component of the ECAIL trial. PG - 22 LID - 10.1186/s13006-026-00812-1 [doi] LID - 22 AB - BACKGROUND: The PrEgnanCy and eArly childhood nutrItion triaL (ECAIL) is a randomised controlled trial targeting socially disadvantaged families in northern France. It aims to evaluate the effectiveness of a multi-level, family-based intervention starting from pregnancy that combines nutritional support with improved access to healthy foods to promote healthy feeding practices and lifestyle behaviours in children. This qualitative study explored breastfeeding (or chest feeding) intentions, practices, and social representations among 47 birthing parents (mothers) participating in the trial. METHODS: Semi-structured interviews were conducted in participants' homes from April 2022 to May 2023 (Lille) and from February to June 2024 (Valenciennes). Interviews lasted an average of 61 min (SD 24; range 24-169) and were conducted when children were 16 to 26 months old. The interview guide drew on the three components of the COM-B model (Capability, Opportunity, Motivation). All interviews were manually transcribed verbatim and analysed in NVivo using thematic coding. An inter-coder reliability check was performed to ensure consistency. RESULTS: Four main themes emerged, broadly following the course of breastfeeding: intention, initiation, continuation, and cessation. Most mothers intended to breastfeed, motivated by perceived health benefits, emotional bonding, previous positive experiences, social support, family norms and religious beliefs. Women reported challenges during initiation and continuation, including pain, low milk supply, latching difficulties, fatigue, limited professional support after returning home, and social pressures, sometimes leading to frustration, guilt, or premature cessation. Participants highlighted advantages such as convenience, cost savings, and improved infant digestion and immunity. Workplace and logistical challenges were also reported, notably the lack of suitable spaces for milk expression. CONCLUSION: These findings highlight the need to address structural determinants-particularly social opportunity-to support breastfeeding in socially vulnerable contexts. Because of the difficulties encountered after postnatal discharge, early home visits combined with peer support may offer tailored guidance during a pivotal period and help strengthen maternal confidence. Improving the visibility and acceptability of breastfeeding in public and professional settings, and creating more welcoming environments, represents an important policy lever. In contexts where research on disadvantaged populations remains limited, these findings provide useful insight for developing targeted, context-sensitive lactation support strategies. TRIAL REGISTRATION: Clinical Trials.gov: NCT03003117, registered on 21 December 2016. FAU - Poquet, Delphine AU - Poquet D AD - Universite Paris Cite and Universite Sorbonne Paris Nord, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Inserm, Paris, F-75004, France. FAU - de Lauzon-Guillain, Blandine AU - de Lauzon-Guillain B AD - Universite Paris Cite and Universite Sorbonne Paris Nord, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Inserm, Paris, F-75004, France. FAU - Ley, Delphine AU - Ley D AD - Universite Lille, Inserm, CHU Lille, U1286 - INFINITE - Institute for Translational Research in Inflammation, Lille, France. AD - CHU Lille, Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Lille, France. FAU - Charles, Marie-Aline AU - Charles MA AD - Universite Paris Cite and Universite Sorbonne Paris Nord, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Inserm, Paris, F-75004, France. FAU - Sauvegrain, Priscille AU - Sauvegrain P AD - Universite Paris Cite and Universite Sorbonne Paris Nord, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Inserm, Paris, F-75004, France. AD - University Midwifery Department, Sorbonne Universite, Paris, F-75013, France. FAU - Lioret, Sandrine AU - Lioret S AD - Universite Paris Cite and Universite Sorbonne Paris Nord, INRAE, Centre for Research in Epidemiology and StatisticS (CRESS), Inserm, Paris, F-75004, France. sandrine.lioret@inserm.fr. AD - Obstetric, Perinatal, Paediatric, Lifecourse Epidemiology (OPPaLE) Team Inserm UMR 1153, Centre for Research in Epidemiology and Statistics (CRESS), 16 avenue Paul Vaillant-Couturier, Batiment Leriche, Perinatal, Villejuif cedex, Paediatric, 94807, France. sandrine.lioret@inserm.fr. LA - eng SI - ClinicalTrials.gov/NCT03003117 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260123 PL - England TA - Int Breastfeed J JT - International breastfeeding journal JID - 101251562 SB - IM MH - Humans MH - Female MH - *Breast Feeding/psychology MH - Adult MH - Infant MH - *Mothers/psychology MH - Qualitative Research MH - France MH - *Intention MH - *Health Knowledge, Attitudes, Practice MH - Child, Preschool MH - *Vulnerable Populations/psychology MH - Pregnancy PMC - PMC12911340 OTO - NOTNLM OT - Breastfeeding OT - Chest feeding OT - Intervention OT - Poverty OT - Process evaluation OT - Qualitative research OT - Social norms COIS- Declarations. Ethics approval and consent to participate: The ECAIL randomised controlled trial was approved by the committee for protection of participants engaged in human research (Comite de Protection des Personnes Nord-Ouest 1 [CPP], 24/07/2014), the national advisory committee on information processing in health research (Comite Consultatif sur le Traitement de l'Information en matiere de Recherche Scientifique, 04/09/2014), and the French Data Protection Authority (Commission Nationale de l'Informatique et des Libertes, 15/06/2016). The protocol for the qualitative component was approved by the Nord-Ouest 1 CPP on 28/06/2021. Written and signed consent were obtained from all participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/24 06:35 MHDA- 2026/06/27 12:37 PMCR- 2026/01/23 CRDT- 2026/01/24 00:03 PHST- 2025/06/03 00:00 [received] PHST- 2026/01/10 00:00 [accepted] PHST- 2026/06/27 12:37 [medline] PHST- 2026/01/24 06:35 [pubmed] PHST- 2026/01/24 00:03 [entrez] PHST- 2026/01/23 00:00 [pmc-release] AID - 10.1186/s13006-026-00812-1 [pii] AID - 812 [pii] AID - 10.1186/s13006-026-00812-1 [doi] PST - epublish SO - Int Breastfeed J. 2026 Jan 23;21(1):22. doi: 10.1186/s13006-026-00812-1. PMID- 41578297 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1472-6874 (Electronic) IS - 1472-6874 (Linking) VI - 26 IP - 1 DP - 2026 Jan 23 TI - Health-related quality of life (HRQoL) and associated factors among women with polycystic ovary syndrome (PCOS) attending an infertility center in Nepal: a cross-sectional study. PG - 109 LID - 10.1186/s12905-026-04280-x [doi] LID - 109 AB - BACKGROUND: Polycystic ovary syndrome (PCOS) significantly impairs women's health -related quality of life (HRQoL), yet evidence from Nepal remains limited. This study aimed to assess HRQoL and associated factors among women with PCOS attending an infertility center in Kathmandu, Nepal. METHODS: A hospital-based cross-sectional study was conducted from March to September 2023 among 135 women aged 18-45 years diagnosed with PCOS, selected through simple random sampling. Data were collected through face-to-face interviews using validated instruments: the Polycystic Ovary Syndrome Questionnaire (PCOSQ), the International Physical Activity Questionnaire-Short Form (IPAQ-SF), and the Perceived Stress Scale (PSS-4). Statistical analyses included descriptive statistics, bivariate analyses, and multiple linear regression to identify the factors associated with HRQoL. RESULTS: The mean overall HRQoL score was 5.04 +/- 1.44 on a 7-point scale, with the lowest domain scores observed for infertility (3.34 +/- 1.72), emotional well-being (4.29 +/- 0.97), and menstruation (4.32 +/- 1.13) domains, while the body hair domain was least affected (8.58 +/- 1.86). In adjusted regression, younger age, marital status, higher BMI, acne, menstrual irregularities, fertility-related history, physical inactivity, substance use, and high stress were significantly associated with poorer HRQoL (p < 0.05). CONCLUSION: Women with PCOS in Nepal experience significant impairment in HRQoL, most notably in relation to infertility, emotional well-being, and menstrual irregularities. Both modifiable and non-modifiable factors were associated with poorer HRQoL. These findings highlight the need for a holistic, patient-centered approach that integrates medical, psychological, and lifestyle interventions, particularly in resource-limited settings. FAU - Marasine, Nirmal Raj AU - Marasine NR AUID- ORCID: 0000-0003-4353-382X AD - Department of Pharmacy, CiST College, Pokhara University, Kathmandu, 44600, Nepal. nirmalmarasine@gmail.com. FAU - Aryal, Ambika AU - Aryal A AD - Department of Pharmacy, CiST College, Pokhara University, Kathmandu, 44600, Nepal. FAU - Mahat, Salma AU - Mahat S AD - Department of Pharmacy, CiST College, Pokhara University, Kathmandu, 44600, Nepal. FAU - Gc, Shreejana AU - Gc S AD - Department of Pharmacy, CiST College, Pokhara University, Kathmandu, 44600, Nepal. FAU - Thakuri, Supriya Singh AU - Thakuri SS AD - Department of Pharmacy, CiST College, Pokhara University, Kathmandu, 44600, Nepal. FAU - Pathak, Nabin AU - Pathak N AD - Department of Pharmacy and Clinical Pharmacology, Madan Bhandari Academy of Health Sciences, Hetauda, Nepal. FAU - Paudel, Shishir AU - Paudel S AD - Department of Public Health, CiST College, Pokhara University, Kathmandu, 44600, Nepal. FAU - Sankhi, Sabina AU - Sankhi S AD - Department of Pharmacy, Shree College of Technology, Purbanchal University , Bharatpur-12, Chitwan, 44200, Nepal. LA - eng PT - Journal Article DEP - 20260123 PL - England TA - BMC Womens Health JT - BMC women's health JID - 101088690 SB - IM MH - Humans MH - Female MH - *Quality of Life/psychology MH - *Polycystic Ovary Syndrome/psychology/complications MH - Cross-Sectional Studies MH - Adult MH - Nepal MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - *Infertility, Female/psychology MH - Middle Aged PMC - PMC12910849 OTO - NOTNLM OT - Associated factors OT - Health-related quality of life OT - Infertility center OT - Polycystic ovary syndrome OT - Women COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Institutional Review Committee of CiST (IRC-CiST, Ref no. 66/079/080), and data collection permission was taken from the Infertility Center at Bijulibazar, Kathmandu. Written informed consent was obtained from all participants prior to data collection. For participants who could not read or write, the consent form was read aloud in the Nepali language in the presence of an impartial witness, who then signed the form; participants provided consent by affixing a thumbprint. Consent for publication: N/A. Competing interests: The authors declare no competing interests. EDAT- 2026/01/24 06:35 MHDA- 2026/06/27 18:38 PMCR- 2026/01/23 CRDT- 2026/01/24 00:02 PHST- 2025/06/02 00:00 [received] PHST- 2026/01/11 00:00 [accepted] PHST- 2026/06/27 18:38 [medline] PHST- 2026/01/24 06:35 [pubmed] PHST- 2026/01/24 00:02 [entrez] PHST- 2026/01/23 00:00 [pmc-release] AID - 10.1186/s12905-026-04280-x [pii] AID - 4280 [pii] AID - 10.1186/s12905-026-04280-x [doi] PST - epublish SO - BMC Womens Health. 2026 Jan 23;26(1):109. doi: 10.1186/s12905-026-04280-x. PMID- 41577356 OWN - NLM STAT- MEDLINE DCOM- 20260701 LR - 20260701 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 1 DP - 2026 Jan 23 TI - Effective coverage of maternal, neonatal and child health services based on District Health Information System 2 (DHIS2) data in Ethiopia: a mixed-methods study. PG - e098795 LID - 10.1136/bmjopen-2025-098795 [doi] LID - e098795 AB - OBJECTIVE: Our objective was to assess the feasibility of using the routine health information system data source, District Health Information System (DHIS2) to measure the effective coverage of selected health service indicators in Ethiopia and to explore stakeholder perceptions of those measures. DESIGN: We conducted a mixed-methods study. We mapped the availability of data elements in DHIS2 between July 2022 and June 2023 for five indicators (four or more antenatal care visits (ANC4+), skilled birth attendance, postnatal care, sick child care and child nutrition care). We defined effective coverage cascade steps for each indicator, assessed data quality and analysed data using STATA V.17. Finally, qualitative interviews were conducted with 15 key stakeholders, and the data were analysed thematically for reflections on the DHIS2 output. SETTING: The data were captured from all public health facilities of 11 regions and 2 administrative cities in Ethiopia. RESULTS: There was better availability of data elements for maternal healthcare than for child healthcare. It was possible to estimate the intervention-adjusted coverage of ANC4+ (16% nationally) and the process-quality-adjusted coverage of skilled birth attendance (19% nationally). Postnatal care, sick child care and child nutrition indicators lacked data across multiple cascade steps. The quality of data for effective coverage measurement differed by region. The key informants expressed concerns about the adequacy and appropriateness of DHIS2 data for this analysis. While all acknowledged its potential for decision-making, respondents emphasised the need for standardised methods and data sources to enhance comparability and acceptability of the findings. CONCLUSIONS: The findings underscore the need for system-level improvement of data availability and quality, and adoption of a standardised approach to calculating effective coverage using DHIS2. There was a concern that the findings may not be accepted by policymakers; however, the local level granularity made possible through DHIS2 was appreciated. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Lemma, Seblewengel AU - Lemma S AUID- ORCID: 0000-0001-5910-3723 AD - Department of Population, Policy and Practice, University College London Institute of Child Health, London, UK s.abreham@ucl.ac.uk. FAU - Getachew, Fikreselassie AU - Getachew F AD - Health System and Reproductive Health Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia. FAU - Achamyeleh, Hiwot AU - Achamyeleh H AD - Health System and Reproductive Health Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia. FAU - Tesfa, Anene AU - Tesfa A AD - Health System and Reproductive Health Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia. FAU - Yihun, Bantalem AU - Yihun B AUID- ORCID: 0009-0000-2133-3208 AD - Ethiopia Ministry of Health, Addis Ababa, Ethiopia. FAU - Kassahun Gelaw, Solomon AU - Kassahun Gelaw S AD - Ethiopia Ministry of Health, Addis Ababa, Ethiopia. FAU - Getachew, Theodros AU - Getachew T AUID- ORCID: 0000-0002-6486-0531 AD - Health System and Reproductive Health Research Directorate, Ethiopian Public Health Institute, Addis Ababa, Ethiopia. AD - Global Health and Population, Harvard T H Chan School of Public Health, Boston, Massachusetts, USA. FAU - Persson, Lars Ake AU - Persson LA AUID- ORCID: 0000-0003-0710-7954 AD - Disease Control, London School of Hygiene and Tropical Medicine, London, UK. FAU - Schellenberg, Joanna AU - Schellenberg J AD - Disease Control, London School of Hygiene and Tropical Medicine, London, UK. FAU - Marchant, Tanya AU - Marchant T AUID- ORCID: 0000-0002-4228-4334 AD - Disease Control, London School of Hygiene and Tropical Medicine, London, UK. LA - eng GR - INV-007644/GATES/Gates Foundation/United States PT - Journal Article DEP - 20260123 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Ethiopia MH - Female MH - *Health Information Systems MH - *Child Health Services/statistics & numerical data/standards MH - Pregnancy MH - Infant, Newborn MH - *Maternal Health Services/statistics & numerical data MH - *Maternal-Child Health Services/statistics & numerical data MH - Infant MH - Qualitative Research MH - Prenatal Care/statistics & numerical data MH - Child MH - Quality Indicators, Health Care PMC - PMC12853494 OTO - NOTNLM OT - Ethiopia OT - Feasibility Studies OT - Health Services Accessibility OT - Quality Improvement OT - Quality in health care COIS- Competing interests: None declared. EDAT- 2026/01/24 00:32 MHDA- 2026/01/24 00:33 PMCR- 2026/01/23 CRDT- 2026/01/23 20:32 PHST- 2026/01/24 00:33 [medline] PHST- 2026/01/24 00:32 [pubmed] PHST- 2026/01/23 20:32 [entrez] PHST- 2026/01/23 00:00 [pmc-release] AID - bmjopen-2025-098795 [pii] AID - 10.1136/bmjopen-2025-098795 [doi] PST - epublish SO - BMJ Open. 2026 Jan 23;16(1):e098795. doi: 10.1136/bmjopen-2025-098795. PMID- 41576855 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260729 IS - 1873-7862 (Electronic) IS - 0924-977X (Linking) VI - 105 DP - 2026 Apr TI - Antipsychotic plasma concentration as predictor of movement disorders and cardiometabolic side-effects: A comparison with prescription dose. PG - 112769 LID - S0924-977X(26)00010-6 [pii] LID - 10.1016/j.euroneuro.2026.112769 [doi] AB - The clinical evidence for antipsychotic (AP) therapeutic drug monitoring (TDM) in evaluating AP-related movement disorders and cardiometabolic side-effects remains inconsistent. This study evaluates how AP plasma concentrations associate with movement disorders and cardiometabolic side-effects over time, and compares its predictive value to prescription dose in first-episode psychosis (FEP) patients. We included 200 remitted FEP patients from the HAMLETT trial. AP plasma concentrations were standardized using robust z-scores to accommodate different AP types. The St. Hans Rating Scale and Barnes Akathisia Rating Scale assessed movement disorders. Cardiometabolic indices included body mass index, waist circumference, blood pressure, glucose, triglycerides, and cholesterol. We evaluated longitudinal associations between plasma concentrations, movement disorders and cardiometabolic side-effects using two-part and linear mixed-effects models, and compared its predictive value to prescription dose using Bayesian Information Criterion (DeltaBIC). Over a median 6-month follow-up (range = 0-48), AP plasma concentrations were positively associated with odds for parkinsonism (OR = 1.81, 95 % CI 1.27, 2.57, p = 0.001). No associations were found with tardive dyskinesia, akathisia, tardive dystonia, or cardiometabolic indices. AP plasma concentrations predicted parkinsonism better than prescription dose (DeltaBIC = -2.95), but showed lower predictive value for waist circumference (DeltaBIC = 3.22), total cholesterol (DeltaBIC = 3.70), low-density-lipoprotein cholesterol (DeltaBIC = 2.14) and non-high-density-lipoprotein cholesterol (DeltaBIC = 5.46). These findings suggest that in remitted FEP patients, AP TDM may be more useful than dose in evaluating parkinsonism, likely because plasma concentrations more closely reflect free drugs at striatal dopamine receptors, but it does not appear useful for cardiometabolic side-effects. CI - Copyright (c) 2026 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Liu, Yinzhao AU - Liu Y AD - Centers for Clinical Neuroscience and Cognition, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the Netherlands. Electronic address: y.liu04@umcg.nl. FAU - Sommer, Iris E AU - Sommer IE AD - Centers for Clinical Neuroscience and Cognition, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the Netherlands. FAU - Schoretsanitis, Georgios AU - Schoretsanitis G AD - Department of Adult Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland; Psychiatry Research, Northwell Health, The Zucker Hillside Hospital, 75-59 263rd Street, Glen Oaks, NY 11004, USA; Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY 11549, USA. FAU - Hamers, Iris AU - Hamers I AD - Centers for Clinical Neuroscience and Cognition, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the Netherlands. FAU - Scheurink, Toon A W AU - Scheurink TAW AD - Centers for Clinical Neuroscience and Cognition, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the Netherlands. FAU - Begemann, Marieke J H AU - Begemann MJH AD - Centers for Clinical Neuroscience and Cognition, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the Netherlands. FAU - Gangadin, Shiral S AU - Gangadin SS AD - Centers for Clinical Neuroscience and Cognition, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the Netherlands. FAU - van Beveren, Nico J M AU - van Beveren NJM AD - Parnassia Group for Mental Health Care, The Hague, the Netherlands; Department of Neuroscience, Erasmus Medical Centre, Rotterdam, the Netherlands; Department of Psychiatry, Erasmus Medical Centre, Rotterdam, the Netherlands. CN - HAMLETT and OPHELIA Consortium AD - Centers for Clinical Neuroscience and Cognition, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the Netherlands. FAU - Koops, Sanne AU - Koops S AD - Centers for Clinical Neuroscience and Cognition, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the Netherlands. FAU - Bakker, P Roberto AU - Bakker PR AD - Centers for Clinical Neuroscience and Cognition, University Medical Center Groningen (UMCG), University of Groningen, Groningen, the Netherlands; Arkin, Institute for Mental Health, Amsterdam, the Netherlands; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MheNS), Maastricht University Medical Centre, Maastricht, the Netherlands. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20260122 PL - Netherlands TA - Eur Neuropsychopharmacol JT - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JID - 9111390 RN - 0 (Antipsychotic Agents) SB - IM MH - Humans MH - Female MH - Male MH - *Antipsychotic Agents/blood/adverse effects MH - Adult MH - Drug Monitoring MH - *Movement Disorders/blood/diagnosis MH - Predictive Value of Tests MH - Young Adult MH - *Psychotic Disorders/drug therapy/blood MH - *Cardiovascular Diseases/chemically induced/blood MH - Dose-Response Relationship, Drug MH - Longitudinal Studies MH - Middle Aged MH - Adolescent OTO - NOTNLM OT - Antipsychotic agents OT - Extrapyramidal side effects OT - Metabolic syndrome OT - Therapeutic drug monitoring COIS- Declaration of competing interest I.E.S. participates in a trial from Boehringer-Ingelheim, has received speakers' fee from Otsuka, and a charity grant from Janssen. Other authors have no conflicts of interest to declare. FIR - Sommer, Iris IR - Sommer I IRAD- Centers for Clinical Neuroscience and Cognition, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. FIR - de Haan, Lieuwe IR - de Haan L IRAD- Department of Early Psychosis, Amsterdam UMC, Academic Medical Center, Amsterdam, the Netherlands. FIR - Veling, Wim IR - Veling W IRAD- Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. FIR - van Os, Jim IR - van Os J IRAD- Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands; Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University Medical Centre, Maastricht, the Netherlands; King's College London, King's Health Partners Department of Psychosis Studies; Institute of Psychiatry, Psychology & Neuroscience, London, United Kingdom. FIR - Smit, Filip IR - Smit F IRAD- Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, location VUmc, Amsterdam, the Netherlands; Department of Clinical, Neuro and Developmental Psychology, Amsterdam Public Health Research Institute, Vrije Universiteit, Amsterdam, the Netherlands; Centre of Economic Evaluation & Machine Learning, Trimbos Institute (Netherlands Institute of Mental Health), Utrecht, the Netherlands. FIR - Begemann, Marieke IR - Begemann M IRAD- Centers for Clinical Neuroscience and Cognition, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. FIR - Koops, Sanne IR - Koops S IRAD- Centers for Clinical Neuroscience and Cognition, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. FIR - Marcelis, Machteld IR - Marcelis M IRAD- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University Medical Centre, Maastricht, the Netherlands; Institute for Mental Health Care Eindhoven (GGzE), Eindhoven, the Netherlands. FIR - Kikkert, Martijn IR - Kikkert M IRAD- Department of Research, Arkin Mental Health Care, Amsterdam, the Netherlands. FIR - van Beveren, Nico IR - van Beveren N IRAD- Antes Center for Mental Health Care, Rotterdam, the Netherlands; Department of Neuroscience, Erasmus MC, Rotterdam, the Netherlands. FIR - Boonstra, Nynke IR - Boonstra N IRAD- Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands; NHL Stenden, University of Applied Sciences, Leeuwarden, the Netherlands; KieN VIP Mental Health Care Services, Leeuwarden, the Netherlands. FIR - Rosema, Bram-Sieben IR - Rosema BS IRAD- Centers for Clinical Neuroscience and Cognition, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. FIR - Bakker, P Roberto IR - Bakker PR IRAD- Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Research, Arkin Mental Health Care, Amsterdam, the Netherlands. FIR - Guloksuz, Sinan IR - Guloksuz S IRAD- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University Medical Centre, Maastricht, the Netherlands; Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA. FIR - Lokkerbol, Joran IR - Lokkerbol J IRAD- Centre of Economic Evaluation & Machine Learning, Trimbos Institute (Netherlands Institute of Mental Health), Utrecht, the Netherlands. FIR - Wijnen, Ben IR - Wijnen B IRAD- Centre of Economic Evaluation & Machine Learning, Trimbos Institute (Netherlands Institute of Mental Health), Utrecht, the Netherlands. FIR - Brand, Bodyl IR - Brand B IRAD- Department of Psychiatry, University of Oxford, Oxford, United Kingdom. FIR - Gangadin, Shiral IR - Gangadin S IRAD- Centers for Clinical Neuroscience and Cognition, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands. FIR - Erna van 't, Hag IR - Erna van 't H IRAD- Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. FIR - Oomen, Priscilla IR - Oomen P IRAD- Behavioural Science Institute, Radboud University, Nijmegen, the Netherlands. FIR - Voppel, Alban IR - Voppel A IRAD- Centers for Clinical Neuroscience and Cognition, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Douglas Mental Health University Center, McGill University, Montreal, Canada. FIR - de Beer, Franciska IR - de Beer F IRAD- Centers for Clinical Neuroscience and Cognition, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. FIR - Kamphuis, Sterre IR - Kamphuis S IRAD- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University Medical Centre, Maastricht, the Netherlands. FIR - Hamers, Iris IR - Hamers I IRAD- Centers for Clinical Neuroscience and Cognition, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. FIR - Djordjevic, Matej IR - Djordjevic M IRAD- Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. FIR - Scheurink, Toon IR - Scheurink T IRAD- Centers for Clinical Neuroscience and Cognition, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. FIR - Noorman, Jort IR - Noorman J IRAD- Centers for Clinical Neuroscience and Cognition, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. FIR - van Amelsvoort, Therese IR - van Amelsvoort T IRAD- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University Medical Centre, Maastricht, the Netherlands; Mondriaan Mental Health Care, Heerlen, the Netherlands. FIR - Bak, Maarten IR - Bak M IRAD- Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience (MHeNs), Maastricht University Medical Centre, Maastricht, the Netherlands; Mondriaan Mental Health Care, Heerlen, the Netherlands. FIR - Berendsen, Steven IR - Berendsen S IRAD- Department of Early Psychosis, Amsterdam UMC, Academic Medical Center, Amsterdam, the Netherlands; Dimence Institute for Mental Health, Deventer, Zwolle, the Netherlands. FIR - van den Brink, Truus IR - van den Brink T IRAD- Early Intervention Team, GGZ Centraal, Amersfoort, the Netherlands. FIR - Faber, Gunnar IR - Faber G IRAD- Yulius, Mental Health Institute, Dordrecht, the Netherlands. FIR - Grootens, Koen IR - Grootens K IRAD- Reinier van Arkel Institute for Mental Health Care, 's Hertogenbosch, the Netherlands; Tranzo, TSB, Tilburg University, Tilburg, the Netherlands. FIR - de Jonge, Martin IR - de Jonge M IRAD- Program for Psychosis & Severe Mental Illness, Pro Persona Mental Health, Wolfheze, the Netherlands. FIR - Knegtering, Henderikus IR - Knegtering H IRAD- Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Lentis Research, Lentis Psychiatric Institute, Groningen, the Netherlands. FIR - Kurkamp, Jorg IR - Kurkamp J IRAD- Center for Youth with Psychosis, Mediant ABC Twente, Enschede, the Netherlands. FIR - Pijnenborg, Gerdina Hendrika Maria IR - Pijnenborg GHM IRAD- Department of Psychotic Disorders, GGZ-Drenthe, Assen, the Netherlands; Department of clinical and developmental neuropsychology, faculty BSS, University of Groningen, Groningen, the Netherlands. FIR - Staring, Anton IR - Staring A IRAD- Department ABC Early Psychosis, Altrecht Psychiatric Institute, Utrecht, the Netherlands; Psychologist Netherlands, Psychosis department, Utrecht, the Netherlands. FIR - Veen, Natalie IR - Veen N IRAD- GGZ Delfland, Delfland Institute for Mental Health Care, Delft, the Netherlands. FIR - Veerman, Selene IR - Veerman S IRAD- Community Mental Health, Mental Health Service Noord-Holland Noord, Schagen, the Netherlands. FIR - Wiersma, Sybren IR - Wiersma S IRAD- Early Intervention Psychosis Team, GGZ inGeest Specialized Mental Health Care, Hoofddorp, the Netherlands. FIR - Batalla, Albert IR - Batalla A IRAD- Department of Psychiatry, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, the Netherlands. FIR - Curfs, Ruben IR - Curfs R IRAD- Parnassia Psychiatric Institute, The Hague, the Netherlands. FIR - Hage, Jan-Jaap IR - Hage JJ IRAD- GGZ Breburg, Tilburg, the Netherlands. FIR - Graveland, Ellen IR - Graveland E IRAD- Yulius, Mental Health Institute, Dordrecht, the Netherlands. FIR - Hoornaar, Joelle IR - Hoornaar J IRAD- Antes Center for Mental Health Care, Rotterdam, the Netherlands. FIR - Hobus, Inge IR - Hobus I IRAD- Centers for Clinical Neuroscience and Cognition, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands; Janssen-Cilag B.V., Breda, the Netherlands. FIR - Huizer, Karin IR - Huizer K IRAD- Parnassia Psychiatric Institute, The Hague, the Netherlands; Department of Psychiatry, Amsterdam UMC, Academic Medical Center, Amsterdam, the Netherlands; Department of Pathology, Erasmus MC, Rotterdam, the Netherlands. EDAT- 2026/01/24 00:32 MHDA- 2026/02/19 01:35 CRDT- 2026/01/23 18:10 PHST- 2025/09/12 00:00 [received] PHST- 2026/01/08 00:00 [revised] PHST- 2026/01/12 00:00 [accepted] PHST- 2026/02/19 01:35 [medline] PHST- 2026/01/24 00:32 [pubmed] PHST- 2026/01/23 18:10 [entrez] AID - S0924-977X(26)00010-6 [pii] AID - 10.1016/j.euroneuro.2026.112769 [doi] PST - ppublish SO - Eur Neuropsychopharmacol. 2026 Apr;105:112769. doi: 10.1016/j.euroneuro.2026.112769. Epub 2026 Jan 22. PMID- 41576048 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260123 LR - 20260126 IS - 2767-3375 (Electronic) IS - 2767-3375 (Linking) VI - 6 IP - 1 DP - 2026 TI - Exploring the multilevel determinants of low birth weight in Bangladesh: Understanding implications for targeted public health interventions. PG - e0005823 LID - 10.1371/journal.pgph.0005823 [doi] LID - e0005823 AB - Low birth weight (LBW), a key indicator of impaired fetal growth, is strongly associated with infant morbidity, mortality, and long-term health problems, particularly in developing countries such as Bangladesh. LBW reflects complex public health challenges shaped by interlinked factors across health, education, and socioeconomic sectors, where low maternal education, limited household income, poor nutrition, inadequate healthcare access, and insufficient antenatal care contribute to adverse birth outcomes. Understanding these multilevel determinants is essential for designing effective public health interventions. This study examined the prevalence and determinants of LBW in Bangladesh while accounting for both individual- and community-level factors using data from the 2022 Bangladesh Demographic and Health Survey. The analysis included 5,342 newborns with recorded birth weights from births occurring within the five years preceding the survey. Birth weight was classified as LBW, defined as less than 2,500 grams, or normal birth weight of at least 2,500 grams. Binary logistic regression was applied to identify associated risk factors, and adjusted odds ratios with 95% confidence intervals were reported using a significance level of p < 0.05. Multilevel logistic regression models were additionally employed to capture community-level variation and improve model fit and predictive performance. The prevalence of LBW was 9.15%, with significant associations observed for administrative division, place of residence, household wealth index, mode of delivery, number of antenatal care visits, and place of delivery. Random-effects estimates showed reduced cluster-level variability across models, with the intraclass correlation coefficient declining from 10.65% to 6.66% and the median odds ratio decreasing from 1.81 to 1.58, indicating improved explanatory power after adjustment. Overall, LBW in Bangladesh is influenced by maternal characteristics, socioeconomic conditions, healthcare utilization, and contextual factors, underscoring the need for targeted interventions that strengthen maternal healthcare services, expand antenatal care coverage, and address socioeconomic disparities to reduce LBW prevalence and related risks. CI - Copyright: (c) 2026 Ali et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Ali, Akher AU - Ali A AD - Department of Statistics and Data Science, Jahangirnagar University, Savar, Dhaka, Bangladesh. FAU - Hasan, Md Kamrul AU - Hasan MK AD - Department of Statistics and Data Science, Jahangirnagar University, Savar, Dhaka, Bangladesh. FAU - Amin, Ruhul AU - Amin R AUID- ORCID: 0009-0003-2325-1400 AD - Department of Statistics and Data Science, Jahangirnagar University, Savar, Dhaka, Bangladesh. FAU - Kabir, Mohammad Alamgir AU - Kabir MA AD - Department of Statistics and Data Science, Jahangirnagar University, Savar, Dhaka, Bangladesh. FAU - Junaid, Sheikh Mohammad AU - Junaid SM AUID- ORCID: 0009-0001-6074-3098 AD - Department of Statistics and Data Science, Jahangirnagar University, Savar, Dhaka, Bangladesh. LA - eng PT - Journal Article DEP - 20260123 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC12829852 COIS- The authors have declared that no competing interests exist. EDAT- 2026/01/23 18:35 MHDA- 2026/01/23 18:36 PMCR- 2026/01/23 CRDT- 2026/01/23 13:53 PHST- 2025/04/09 00:00 [received] PHST- 2025/12/26 00:00 [accepted] PHST- 2026/01/23 18:36 [medline] PHST- 2026/01/23 18:35 [pubmed] PHST- 2026/01/23 13:53 [entrez] PHST- 2026/01/23 00:00 [pmc-release] AID - PGPH-D-25-00823 [pii] AID - 10.1371/journal.pgph.0005823 [doi] PST - epublish SO - PLOS Glob Public Health. 2026 Jan 23;6(1):e0005823. doi: 10.1371/journal.pgph.0005823. eCollection 2026. PMID- 41576020 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260123 LR - 20260126 IS - 2767-3375 (Electronic) IS - 2767-3375 (Linking) VI - 6 IP - 1 DP - 2026 TI - Prevalence and its associated factors of inadequate dietary diversity among pregnant women attending antenatal care in selected public health facilities in Addis Ababa, Ethiopia. PG - e0005575 LID - 10.1371/journal.pgph.0005575 [doi] LID - e0005575 AB - Adequate dietary diversity during pregnancy is crucial for the well-being and growth of both the mother and the child. Many pregnant women in Ethiopia, including in Addis Ababa, suffer from poor dietary diversity and associated malnutrition. However, previous studies conducted in Addis Ababa are limited in scope. Therefore, this study assessed inadequate dietary diversity and its associated factors among pregnant women attending antenatal care in selected public health facilities in Addis Ababa, Ethiopia. A facility-based cross-sectional study was carried out among 615 pregnant women in Addis Ababa who were receiving antenatal care at selected public health facilities. A systematic random sampling technique was used to select the study participants. Data were collected using a structured pretested questionnaire. The validated 10 food group dietary diversity questions were used to elicit dietary diversity. This study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board (IRB) of Menelik II Medical and Health Science Collage (Ref.No.5/38/12/1985). The data were entered on Epi-info version 7.2.1.0 and exported to SPSS version 23.0 for analysis. Logistic regression analysis was used to identify factors associated with low dietary diversity. In general, 55.8% of pregnant women had inadequate dietary diversity. Significant factors included lack of education (AOR = 3.75, 95% CI: 1.96,7.15), low income (AOR = 1.67, 95% CI: 1.02,2.74), lack of nutritional counseling (AOR = 1.68, 95% CI: 1.06,2.68) and household food insecurity (AOR = 5.33,95%CI:2.05,13.81), which were factors associated with inadequate dietary diversity among pregnant women, respectively. The magnitude of inadequate dietary diversity remains high among pregnant women in Addis Ababa. Having low income, being unable to read and write, lacking counseling about dietary diversity, and having household food insecurity were significantly associated with inadequate diversified dietary. Therefore, enhancing women's education, offering counselling on dietary diversity, and implementing sustainable income-generating and food security interventions activities are crucial. CI - Copyright: (c) 2026 Mokonen, Gemaneh. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Mokonen, Zinash Getachew AU - Mokonen ZG AUID- ORCID: 0009-0009-9682-9289 AD - Deparment of Psychiatry, Addis Ababa City Administration Health Bureau, Arada Afencho ber Health Center, Addis Ababa, Ethiopia. FAU - Gemaneh, Haimanot Teferi AU - Gemaneh HT AUID- ORCID: 0000-0003-3528-689X AD - Department of Medical Laboratory, Addis Ababa City Administration Health Bureau, Bole Dil-frie Health Center, Addis Ababa, Ethiopia. LA - eng PT - Journal Article DEP - 20260123 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC12829869 COIS- The authors have declared that no competing interests exist. EDAT- 2026/01/23 18:35 MHDA- 2026/01/23 18:36 PMCR- 2026/01/23 CRDT- 2026/01/23 13:44 PHST- 2025/09/04 00:00 [received] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/01/23 18:36 [medline] PHST- 2026/01/23 18:35 [pubmed] PHST- 2026/01/23 13:44 [entrez] PHST- 2026/01/23 00:00 [pmc-release] AID - PGPH-D-25-02582 [pii] AID - 10.1371/journal.pgph.0005575 [doi] PST - epublish SO - PLOS Glob Public Health. 2026 Jan 23;6(1):e0005575. doi: 10.1371/journal.pgph.0005575. eCollection 2026. PMID- 41575898 OWN - NLM STAT- Publisher LR - 20260313 IS - 1421-9867 (Electronic) IS - 0012-2823 (Linking) DP - 2026 Jan 23 TI - Quality of Care and Burden in Patients with Celiac Disease: Results from the German Celiac Registry. PG - 1-13 LID - 10.1159/000550496 [doi] AB - INTRODUCTION: European and National Celiac Disease (CeD) guidelines offer an easy pathway to diagnose CeD. The German CeD Registry aimed to assess symptoms and clinical findings before diagnosis, diagnostic delay, care during the diagnostic process, and factors associated with persistence of symptoms. METHODS: Individuals with CeD provided demographic, clinical, and healthcare-related information. Participants were divided into four subgroups according to age at diagnosis (>18 or <18 years) and year of diagnosis (before and since 2012). Factors associated with symptoms after at least 1 year on a gluten-free diet (GFD) were assessed using multivariate logistic regression. RESULTS: From 11/2019 to 10/2021, 2,333 participants were enrolled. After exclusion of 169 (7.2%), 2,164 remained for analysis, thereof 796 (36.8%) were diagnosed <18 years, and 1,283 (59.3%) since 2012. Most common symptoms before diagnosis included abdominal pain (83%), bloating (82%), fatigue (78%), and diarrhoea (71%). Diagnostic delay after 2012 was longer in adults than children (median 4.4 years [interquartile range; IQR: 1.2-13.0] versus 1.1 [IQR: 0.5-2.2], respectively) (p < 0.001). Guideline-conform diagnoses increased over time. After diagnosis, only 60% received professional dietary counselling. Factors associated with symptoms despite GFD included female gender (odds ratio [OR]: 1.79 [95% confidence interval: 1.34; 2.40], p < 0.001), same symptom before diagnosis (OR: 3.45 [2.45; 4.96], p < 0.001), insufficient information provided at diagnosis (OR: 1.25 [1.00; 1.57], p = 0.046), and age at diagnosis (per decade) (OR: 1.11 [1.04; 1.18], p < 0.001) but not time since diagnosis. CONCLUSIONS: Our findings revealed deficits in awareness, the diagnostic process, and post-diagnostic care that are linked to decreased clinical improvement over time. CI - (c) 2026 S. Karger AG, Basel. FAU - Koletzko, Sibylle AU - Koletzko S AD - Department of Paediatrics, Dr. von Hauner Children's Hospital, LMU University Hospital, LMU Munich, Munich, Germany, sibylle.koletzko@med.uni-muenchen.de. AD - Department of Paediatrics, School of Medicine Collegium Medicum University of Warmia and Mazury, Olsztyn, Poland, sibylle.koletzko@med.uni-muenchen.de. FAU - Sobotzki, Christina AU - Sobotzki C AD - Competence Network IBD, Kiel, Germany. FAU - Blomacher, Margit AU - Blomacher M AD - Competence Network IBD, Kiel, Germany. FAU - Plachta-Danielzik, Sandra AU - Plachta-Danielzik S AD - Competence Network IBD, Kiel, Germany. FAU - Schumann, Michael AU - Schumann M AD - Department of Gastroenterology, Rheumatology and infectious Diseases, Campus Benjamin Franklin, Charite-Universitatsmedizin Berlin, Berlin, Germany. FAU - Baas, Stephanie AU - Baas S AD - Zoliakieberatung, Hamburg, Germany. FAU - Bokemeyer, Bernd AU - Bokemeyer B AD - Competence Network IBD, Kiel, Germany. AD - University Hospital Schleswig-Holstein, Campus Kiel, Medical Clinic I, Kiel, Germany. AD - Interdisciplinary Crohn Colitis Centre, Minden, Germany. FAU - Schuppan, Detlef AU - Schuppan D AD - Institute of Translational Immunology and Center for Coeliac Disease, Food Allergy and Autoimmunity, Research Center for Immune Therapy (FZI), Mainz, Germany. AD - Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA. LA - eng PT - Journal Article DEP - 20260123 PL - Switzerland TA - Digestion JT - Digestion JID - 0150472 SB - IM OTO - NOTNLM OT - Coeliac disease OT - Diagnostic accuracy OT - Diagnostic delay OT - Persistent symptoms EDAT- 2026/01/23 18:36 MHDA- 2026/01/23 18:36 CRDT- 2026/01/23 13:13 PHST- 2025/09/29 00:00 [received] PHST- 2026/01/12 00:00 [accepted] PHST- 2026/01/23 18:36 [pubmed] PHST- 2026/01/23 18:36 [medline] PHST- 2026/01/23 13:13 [entrez] AID - 000550496 [pii] AID - 10.1159/000550496 [doi] PST - aheadofprint SO - Digestion. 2026 Jan 23:1-13. doi: 10.1159/000550496. PMID- 41574950 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260818 IS - 1463-1326 (Electronic) IS - 1462-8902 (Linking) VI - 28 IP - 4 DP - 2026 Apr TI - Evaluating WHtR and WC cut-offs for abdominal obesity among children and adolescents: Insights from three National Surveys in China. PG - 3011-3019 LID - 10.1111/dom.70488 [doi] AB - AIM: To assess the application of current waist-to-height ratio (WHtR) and waist circumference (WC) evaluation criteria and identify preferred recommendations for public health practise. MATERIALS AND METHODS: Data were from three waves of the Chinese National Survey on Students Constitution and Health (CNSSCH) conducted in 2010, 2014 and 2019; abdominal obesity was classified using four WHtR and WC standards. Age- and sex-specific WHtR and WC percentile curves were generated using the LMS method. Prevalence of central adiposity by WHtR/WC and general obesity by BMI were compared. Predictive performance of the criteria was validated using an independent dataset with cardiometabolic risk factors. RESULTS: WHtR percentile curves showed a relatively flat trend with age in both sexes compared to WC curves. Abdominal obesity prevalence increased significantly from 2010 to 2019 across all criteria: international cut-off (0.46) (21.26%-27.66%), Chinese WC cut-offs (13.77%-19.64%), international WHtR cut-off (0.50) (9.12%-13.01%) and international WC cut-offs (7.95%-11.95%). All abdominal obesity criteria identified substantially more cases than BMI-based general obesity in 2019 (8.14%). The Chinese WC cut-offs showed superior predictive performance compared to the other three standards for cardiometabolic outcomes. CONCLUSIONS: The Chinese WC cut-offs and international cut-off (0.50) are optimal for childhood abdominal obesity screening in China due to their public health applicability. Standardized global criteria are urgently needed to enhance research comparability. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Zhang, Yihang AU - Zhang Y AUID- ORCID: 0009-0004-0604-8803 AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. FAU - Cai, Shan AU - Cai S AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. FAU - Huang, Tianyu AU - Huang T AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. FAU - Li, Jiaxin AU - Li J AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. FAU - Dang, Jiajia AU - Dang J AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. FAU - Chen, Ziyue AU - Chen Z AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. FAU - Liu, Yunfei AU - Liu Y AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. FAU - Hu, Peijin AU - Hu P AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. FAU - Ma, Jun AU - Ma J AUID- ORCID: 0000-0003-3529-1808 AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. FAU - Song, Yi AU - Song Y AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. LA - eng GR - 2024YFC2707901/National Key Research and Development Program of China/ GR - 82273654/National Natural Science Foundation of China/ PT - Journal Article DEP - 20260123 PL - England TA - Diabetes Obes Metab JT - Diabetes, obesity & metabolism JID - 100883645 SB - IM MH - Humans MH - *Obesity, Abdominal/epidemiology/diagnosis MH - Female MH - China/epidemiology MH - Male MH - Child MH - *Waist Circumference MH - Adolescent MH - *Waist-Height Ratio MH - Prevalence MH - *Pediatric Obesity/epidemiology/diagnosis MH - Body Mass Index MH - Health Surveys OTO - NOTNLM OT - cardiovascular disease OT - population study OT - primary care OT - weight management EDAT- 2026/01/23 13:05 MHDA- 2026/03/17 06:48 CRDT- 2026/01/23 08:13 PHST- 2026/01/05 00:00 [revised] PHST- 2025/10/29 00:00 [received] PHST- 2026/01/07 00:00 [accepted] PHST- 2026/03/17 06:48 [medline] PHST- 2026/01/23 13:05 [pubmed] PHST- 2026/01/23 08:13 [entrez] AID - 10.1111/dom.70488 [doi] PST - ppublish SO - Diabetes Obes Metab. 2026 Apr;28(4):3011-3019. doi: 10.1111/dom.70488. Epub 2026 Jan 23. PMID- 41574894 OWN - NLM STAT- MEDLINE DCOM- 20261015 LR - 20261015 IS - 2168-6602 (Electronic) IS - 0890-1171 (Print) IS - 0890-1171 (Linking) VI - 40 IP - 8 DP - 2026 Nov TI - Development and Validation of the Adaptive Eating Scale: Exploratory and Confirmatory Factor Analyses. PG - 947-957 LID - 10.1177/08901171261421070 [doi] AB - PurposeAdaptive eating refers to internally regulated eating that is enjoyable and gently guided by the nutritional quality of foods. Despite growing interest in this construct, there is currently no validated scale to measure adaptive eating among US college students aged >/=18 years. This study aimed to develop and evaluate the psychometric properties of the Adaptive Eating Scale (AES) in a diverse sample of US college students.DesignThirty-seven items were developed to comprise the AES. Students completed AES and measures of intuitive eating, mental health, diet, and anthropometrics.SampleEight hundred and forty-nine university students aged >/=18 years, from racially and ethnically diverse backgrounds.AnalysisThe sample was divided randomly into two. Exploratory Factor Analysis (EFA) was completed on subsample A (n = 424). Confirmatory Factor Analysis (CFA) was conducted on subsample B (n = 425) to confirm factor structure from subsample A.ResultsEFA showed 17 items representing gentle nutrition (GN), unpreoccupied by food cravings (UBFC), enjoyment of food (EOF), and honoring hunger (HH) explained 63.1% of the variance. CFA showed a bifactor model comprising one global factor and four orthogonal factors (GN, UBFC, EOF, and HH) had excellent fit [CFI = 0.972, RMSEA = 0.051, SRMR = 0.048]. GN, EOF, and HH were reliable, and significantly associated with each other, intuitive eating, emotional eating, weight status, and mental health.ConclusionResults showed that AES is best conceptualized as a multidimensional measure with one general factor and specific factors representing GN, EOF, and HH. FAU - Zeraattalab-Motlagh, Sheida AU - Zeraattalab-Motlagh S AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. RINGGOLD: 14743 FAU - Wiesner, Margit AU - Wiesner M AD - Department of Psychological, Health, and Learning Sciences, University of Houston, Houston, TX, USA. RINGGOLD: 14743 FAU - Yoon, Cynthia AU - Yoon C AD - Department of Food Science and Nutrition, Pusan National University, Busan, Republic of Korea. RINGGOLD: 34996 FAU - Sasson, Sarah AU - Sasson S AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. RINGGOLD: 14743 FAU - Betts, Randi AU - Betts R AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. RINGGOLD: 14743 FAU - Johnston, Craig AU - Johnston C AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. RINGGOLD: 14743 FAU - Ledoux, Tracey AU - Ledoux T AD - Department of Health and Human Performance, University of Houston, Houston, TX, USA. RINGGOLD: 14743 LA - eng PT - Journal Article PT - Validation Study DEP - 20260123 PL - United States TA - Am J Health Promot JT - American journal of health promotion : AJHP JID - 8701680 SB - IM MH - Humans MH - Female MH - Factor Analysis, Statistical MH - Psychometrics MH - Male MH - Young Adult MH - *Students/psychology MH - *Feeding Behavior/psychology MH - Adolescent MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Universities MH - Mental Health PMC - PMC13646408 OTO - NOTNLM OT - US OT - college students OT - cross-sectional OT - eating behavior OT - validity COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/01/23 13:05 MHDA- 2026/10/15 07:17 PMCR- 2026/10/08 CRDT- 2026/01/23 07:52 PHST- 2026/10/15 07:17 [medline] PHST- 2026/01/23 13:05 [pubmed] PHST- 2026/01/23 07:52 [entrez] PHST- 2026/10/08 00:00 [pmc-release] AID - 10.1177_08901171261421070 [pii] AID - 10.1177/08901171261421070 [doi] PST - ppublish SO - Am J Health Promot. 2026 Nov;40(8):947-957. doi: 10.1177/08901171261421070. Epub 2026 Jan 23. PMID- 41574666 OWN - NLM STAT- MEDLINE DCOM- 20260622 LR - 20260811 IS - 1461-7277 (Electronic) IS - 1359-1053 (Linking) VI - 31 IP - 8 DP - 2026 Jul TI - Unveiling the relation among mental health, dietary quality, health literacy, loneliness, physical activities, and BMI in young Chinese. PG - 3395-3409 LID - 10.1177/13591053251414515 [doi] AB - This study aims to examine the complex interrelationships among dietary quality, health literacy, loneliness, physical activity, mental health, and BMI (Body Mass Index) among young Chinese individuals, with particular attention to the mediating role of mental health in the pathways linking health behaviors and BMI. A cross-sectional survey was conducted with a diverse sample of Chinese university students (N = 1568) using validated instruments to measure dietary quality, health literacy, loneliness, physical activity, mental health, and BMI. Structural equation modeling (SEM) was employed to test both direct and indirect relationships among the variables. Findings revealed that higher levels of dietary quality, health literacy, and physical activity were significantly associated with better mental health, while loneliness showed a strong negative effect. Mental health was, in turn, negatively associated with BMI. Furthermore, mental health significantly mediated the effects of dietary quality, health literacy, and physical activity on BMI. These results underscore the central role of psychological well-being in converting health knowledge and behaviors into tangible physical outcomes. The study highlights the need for integrated health promotion strategies that address not only physical behaviors and informational competencies but also the emotional and social dimensions of health. Strengthening mental health support and health literacy among youth may enhance the effectiveness of dietary and physical activity interventions, contributing to the broader goals of the Healthy China 2030 initiative. FAU - Chen, Haifeng AU - Chen H AUID- ORCID: 0009-0009-9439-2386 AD - Northeastern University at Qinhuangdao, Hebei Province, China. AD - Northeastern University Research Institute, Qinhuangdao, Hebei Province, China. LA - eng PT - Journal Article DEP - 20260123 PL - England TA - J Health Psychol JT - Journal of health psychology JID - 9703616 SB - IM MH - Humans MH - Female MH - *Health Literacy/statistics & numerical data MH - Male MH - *Mental Health/statistics & numerical data MH - *Exercise/psychology MH - Young Adult MH - Cross-Sectional Studies MH - *Body Mass Index MH - China MH - *Loneliness/psychology MH - *Diet MH - Adolescent MH - Adult MH - Health Behavior MH - Students/psychology OTO - NOTNLM OT - BMI OT - Chinese youth OT - dietary quality OT - health literacy OT - loneliness OT - mental health OT - physical activity OT - structural equation modeling COIS- Declaration of conflicting interestsThe author declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/01/23 13:05 MHDA- 2026/06/22 13:44 CRDT- 2026/01/23 06:33 PHST- 2026/06/22 13:44 [medline] PHST- 2026/01/23 13:05 [pubmed] PHST- 2026/01/23 06:33 [entrez] AID - 10.1177/13591053251414515 [doi] PST - ppublish SO - J Health Psychol. 2026 Jul;31(8):3395-3409. doi: 10.1177/13591053251414515. Epub 2026 Jan 23. PMID- 41573284 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260123 LR - 20260125 IS - 1735-9066 (Print) IS - 2228-5504 (Electronic) IS - 1735-9066 (Linking) VI - 31 IP - 1 DP - 2026 Jan-Feb TI - The Predictive Role of Body Image on Attitude toward Fertility and Childbearing in Mothers with Two to Four Years Old Children. PG - 94-99 LID - 10.4103/ijnmr.ijnmr_280_24 [doi] AB - BACKGROUND: One of the key factors affecting attitudes toward childbearing is women's physical fitness. Dissatisfaction with body image may affect mother's and child's physical and mental health. Therefore, this study aimed to determine the predictive role of body image in shaping attitudes toward childbearing. MATERIALS AND METHODS: This descriptive-predictive study was conducted on 265 mothers with children aged 2-4 years who visited the comprehensive healthcare centers in Kashan, Iran, in 2023-24. The sampling method was multistage clustering. A demographics questionnaire, Soderberg's Attitudes to Fertility and Childbearing Scale, and Littleton's Body Image Concern Inventory were used for data collection. The validity and reliability of the questionnaires were confirmed. Pearson's correlation coefficient and multiple linear regression analysis were used for data analysis in SPSS. The significance level was set at p < 0.05. RESULTS: According to the results, a one-unit increase in women's body image concerns was associated with a 0.309-point decrease in their positive attitudes toward fertility and childbearing. Additionally, there were significant negative correlations between body image concern and the dimensions of attitudes toward fertility and childbearing: the child as a pillar of life (r = -0.20, p < 0.001), the child as an obstacle to a relationship (r = -0.33, p < 0.001), postponing childbearing to the future (r = -0.33, p < 0.001), and childbearing prerequisites (r = -0.02, p < 0.001). CONCLUSIONS: The study findings corroborated the predictive role of body image in shaping attitudes toward fertility and childbearing. Appropriate interventions should be developed to enhance women's body image during pregnancy and identify and control the factors negatively affecting it. CI - Copyright: (c) 2026 Iranian Journal of Nursing and Midwifery Research. FAU - Salehi, Fatemeh AU - Salehi F AD - Department of Midwifery and Reproductive Health, Faculty of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran. FAU - Sahebzad, Elahe Sadeghi AU - Sahebzad ES AD - Department of Midwifery and Reproductive Health, Faculty of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran. FAU - Kheirkhah, Masoumeh AU - Kheirkhah M AD - Department of Midwifery and Reproductive Health, Faculty of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran. FAU - Nasiri, Saeeda AU - Nasiri S AD - Department of Midwifery and Reproductive Health, Faculty of Nursing and Midwifery, Kashan University of Medical Sciences, Kashan, Iran. LA - eng PT - Journal Article DEP - 20260102 PL - India TA - Iran J Nurs Midwifery Res JT - Iranian journal of nursing and midwifery research JID - 101558775 PMC - PMC12823089 OTO - NOTNLM OT - Body image OT - fertility OT - reproductive behavior COIS- Nothing to declare. EDAT- 2026/01/23 06:29 MHDA- 2026/01/23 06:30 PMCR- 2026/01/02 CRDT- 2026/01/23 04:53 PHST- 2024/08/27 00:00 [received] PHST- 2025/07/19 00:00 [revised] PHST- 2025/07/23 00:00 [accepted] PHST- 2026/01/23 06:30 [medline] PHST- 2026/01/23 06:29 [pubmed] PHST- 2026/01/23 04:53 [entrez] PHST- 2026/01/02 00:00 [pmc-release] AID - IJNMR-31-94 [pii] AID - 10.4103/ijnmr.ijnmr_280_24 [doi] PST - epublish SO - Iran J Nurs Midwifery Res. 2026 Jan 2;31(1):94-99. doi: 10.4103/ijnmr.ijnmr_280_24. eCollection 2026 Jan-Feb. PMID- 41572882 OWN - NLM STAT- MEDLINE DCOM- 20260824 LR - 20260824 IS - 2156-535X (Electronic) IS - 2156-5333 (Linking) VI - 15 IP - 5 DP - 2026 Oct TI - Exploring the Acceptability of an Age-Specific Multidimensional Rehabilitation Program for Young Adult Cancer Survivors: A Qualitative Feasibility Study. PG - 347-357 LID - 10.1177/21565333261416758 [doi] AB - PURPOSE: To explore the acceptability of the content and delivery of the age-specific cancer rehabilitation program Young Adults Taking Action (YATAC) from the perspective of young adult cancer survivors (YACSs). METHODS: Nineteen YACSs (aged 18-39) participated. Program acceptability was explored through four focus groups. The Theoretical Framework of Acceptability guided data collection and analysis. Data from the focus groups were deductively analyzed using framework analysis. RESULTS: The YACSs found the YATAC program acceptable and relevant to their needs. The participants reported enhanced physical self-efficacy, improved mood, greater acceptance of their condition, reduced loneliness, and increased confidence in managing daily life. Peer support, practical exercises, and tailored content were identified as particularly valuable. Referring to delivery acceptance, participants described the program format as engaging and supportive, though some found the intensive schedule burdensome. Few suggested removing content; instead, they recommended extending sessions and adding topics such as diet, fertility, and cognitive concerns. The participants also highlighted the need for clearer guidance on accessing resources after the program. Group discussions were generally beneficial; however, some participants expressed discomfort around discussing sensitive topics in mixed settings. CONCLUSION: The YATAC program was well received and perceived as beneficial by YACSs, particularly when sessions were practical, peer-supported, and individualized. The findings support the program's continued development and refinement. IMPLICATIONS FOR CANCER SURVIVORS: This study highlights the importance of peer interaction and personalized content and thoughtful delivery design in survivorship care for young adults. Future research should explore long-term and wider outcomes. FAU - Aagesen, Maria AU - Aagesen M AUID- ORCID: 0000-0002-0476-3692 AD - Occupational Science, User Perspectives and Community-based Interventions, Department of Public Health, University of Southern Denmark, Odense, Denmark. AD - REHPA, The Danish Knowledge Centre for Rehabilitation and Palliative Care, Odense University Hospital, Nyborg, Denmark. AD - Department of Clinical Research, University of Southern Denmark, Odense, Denmark. FAU - Pilegaard, Marc Sampedro AU - Pilegaard MS AD - DEFACTUM, Central Region Denmark, Aarhus, Denmark. AD - Department of Social Medicine and Rehabilitation, Godstrup Hospital, Herning, Denmark. AD - Department of Public Health, Aarhus University, Aarhus, Denmark. FAU - Jorgesen, Dorthe Sosted AU - Jorgesen DS AD - REHPA, The Danish Knowledge Centre for Rehabilitation and Palliative Care, Odense University Hospital, Nyborg, Denmark. AD - Department of Clinical Research, University of Southern Denmark, Odense, Denmark. FAU - Hauken, May Aasebo AU - Hauken MA AD - Centre for Crisis Psychology, Faculty of Psychology, University of Bergen, Bergen, Norway. FAU - la Cour, Karen AU - la Cour K AD - Occupational Science, User Perspectives and Community-based Interventions, Department of Public Health, University of Southern Denmark, Odense, Denmark. LA - eng PT - Journal Article DEP - 20260123 PL - United States TA - J Adolesc Young Adult Oncol JT - Journal of adolescent and young adult oncology JID - 101543508 SB - IM MH - Humans MH - Female MH - Young Adult MH - Feasibility Studies MH - *Cancer Survivors/psychology MH - Adult MH - Male MH - Adolescent MH - Qualitative Research MH - *Neoplasms/rehabilitation MH - Focus Groups OTO - NOTNLM OT - acceptability OT - cancer survivors OT - complex interventions OT - rehabilitation OT - young adults COIS- Author Disclosure StatementThe authors have no relevant financial or nonfinancial interests to disclose. EDAT- 2026/01/23 06:30 MHDA- 2026/08/24 11:37 CRDT- 2026/01/23 04:03 PHST- 2026/08/24 11:37 [medline] PHST- 2026/01/23 06:30 [pubmed] PHST- 2026/01/23 04:03 [entrez] AID - 10.1177/21565333261416758 [doi] PST - ppublish SO - J Adolesc Young Adult Oncol. 2026 Oct;15(5):347-357. doi: 10.1177/21565333261416758. Epub 2026 Jan 23. PMID- 41572802 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260630 IS - 2152-2723 (Electronic) IS - 2152-2715 (Linking) VI - 29 IP - 3 DP - 2026 Mar TI - Screen Use Measurement Tools: A Mapping of Instruments, Gaps, and Future Directions. PG - 140-150 LID - 10.1177/21522715261417288 [doi] AB - Research on screen usage frequently relies on broad measures of "screen time," which fail to differentiate between various types of activities and their effects. To clarify how digital behavior is defined, we conducted a rapid review and methodological mapping of 36 screen use measurement tools. Three independent coders applied a piloted framework to classify measurement constructs, data collection modality (objective logs, self-, or proxy-report), temporal specificity, framing valence, opportunity cost, dyadic/social context, developmental focus, and evidence of reliability and validity. Interrater agreement was high (Fleiss' Kappa; Gwet's AC1). Most instruments used negatively framed item content, emphasizing impairment, dysregulation, or loss of control, focused on adolescents and young adults, and lacked precision in temporal anchoring. Very few assessed opportunity costs, dyadic use, or included validation against device-logged data. No measure emphasized positive or beneficial aspects of screen engagement. These gaps suggest a need for more conceptually balanced tools that integrate objective tracking with context-sensitive self-report items across the lifespan. We propose a blueprint for future development: improve temporal anchoring (e.g., within-day, weekday vs. weekend), broaden age inclusion, assess social and functional context, and report both reliability and validation against behavioral data. Strengthening measurement will advance efforts to identify when, how, and for whom digital behavior supports or undermines well-being. FAU - Shaleha, Rinanda AU - Shaleha R AUID- ORCID: 0000-0001-6448-8461 AD - Department of Human Development and Family Studies, The Pennsylvania State University, University Park, Pennsylvania, USA. AD - Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania, USA. FAU - Roque, Nelson AU - Roque N AD - Department of Human Development and Family Studies, The Pennsylvania State University, University Park, Pennsylvania, USA. AD - Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania, USA. FAU - Andrews, Hailey AU - Andrews H AD - Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania, USA. FAU - Calfee, Kristin AU - Calfee K AD - Department of Human Development and Family Studies, The Pennsylvania State University, University Park, Pennsylvania, USA. AD - Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania, USA. FAU - Lee, Soomi AU - Lee S AD - Department of Human Development and Family Studies, The Pennsylvania State University, University Park, Pennsylvania, USA. AD - Center for Healthy Aging, The Pennsylvania State University, University Park, Pennsylvania, USA. LA - eng PT - Journal Article PT - Review DEP - 20260122 PL - United States TA - Cyberpsychol Behav Soc Netw JT - Cyberpsychology, behavior and social networking JID - 101528721 SB - IM MH - Humans MH - *Screen Time MH - Reproducibility of Results MH - Digital Media OTO - NOTNLM OT - device-logged data OT - digital behavior OT - lifespan development OT - measurement mapping OT - opportunity cost OT - screen use COIS- Author Disclosure StatementThe authors declare no conflicts of interest related to this study. EDAT- 2026/01/23 06:29 MHDA- 2026/03/30 06:29 CRDT- 2026/01/23 02:23 PHST- 2026/03/30 06:29 [medline] PHST- 2026/01/23 06:29 [pubmed] PHST- 2026/01/23 02:23 [entrez] AID - 10.1177/21522715261417288 [doi] PST - ppublish SO - Cyberpsychol Behav Soc Netw. 2026 Mar;29(3):140-150. doi: 10.1177/21522715261417288. Epub 2026 Jan 22. PMID- 41572776 OWN - NLM STAT- MEDLINE DCOM- 20260924 LR - 20261010 IS - 1875-6190 (Electronic) IS - 1570-159X (Print) IS - 1570-159X (Linking) VI - 24 IP - 11 DP - 2026 TI - Associations Among Binge Eating Behaviors, Emotion Regulation, and Chronotype in Female Greek University Students. PG - 1765-1776 LID - 10.2174/011570159X431924251127110942 [doi] AB - INTRODUCTION: This study aimed to examine the associations among binge eating behaviors (BEBs), emotion regulation (ER), and chronotypes, and whether ER mediates the relationship between chronotypes and BEBs in Greek female university students, a population in which these associations have not previously been investigated. METHODS: This study was approved by the Research and Ethics Committee of the Medical School of Aristotle University of Thessaloniki (No. 91/23, dated 17/02/2023). A total of 269 female students (mean age (+/-SD) = 21.07 (+/-4.36)) from Aristotle University of Thessaloniki participated in this cross-sectional study. Participants completed a sociodemographic questionnaire and four validated instruments: the Eating Disorder Examination Questionnaire, the Binge Eating Scale, the Difficulties in Emotion Regulation Scale, and the Morningness-Eveningness Questionnaire. RESULTS: BEBs were significantly correlated with eating psychopathology (rs = 0.723, p < 0.001) and with difficulties in emotion regulation (ER) (rs = 0.429, p < 0.001). ER difficulties were also associated with eating psychopathology (rs = 0.434, p < 0.001). An evening chronotype was significantly associated with greater ER difficulties (rs = -0.150, 0.014). Mediation analysis indicated that ER difficulties fully mediated the relationship between eveningness and BEBs (Indirect Effect = -0.06, 95% CI: -0.11 to -0.01). DISCUSSION: ER difficulties are associated with both BEBs and eveningness. While eveningness is not directly associated with BEBs, it is indirectly related through ER difficulties, suggesting a potential psychological mechanism underlying this relationship. CONCLUSION: ER difficulties may be a key mechanism linking evening chronotype to BEBs. Future studies could explore whether interventions targeting ER and circadian alignment are beneficial for managing BEBs among individuals with an evening chronotype. CI - Copyright(c) Bentham Science Publishers; For any queries, please email at epub@benthamscience.net. FAU - Karakosta, Efi AU - Karakosta E AUID- ORCID: 0009-0004-2897-8243 AD - 3rd Department of Psychiatry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Tsapakis, Evangelia-Maria AU - Tsapakis EM AUID- ORCID: 0000-0002-2649-6732 AD - 3rd Department of Psychiatry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Konsta, Anastasia AU - Konsta A AUID- ORCID: 0000-0002-7165-5608 AD - 1st Department of Psychiatry, Papageorgiou General Hospital of Thessaloniki, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Lan, Anat AU - Lan A AUID- ORCID: 0000-0002-8547-2482 AD - School of Behavioral Sciences, Tel Aviv-Yaffo Academic College, Tel Aviv, Israel. FAU - Einat, Haim AU - Einat H AUID- ORCID: 0000-0001-7025-5541 AD - 3rd Department of Psychiatry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece. AD - School of Behavioral Sciences, Tel Aviv-Yaffo Academic College, Tel Aviv, Israel. FAU - Fountoulakis, Konstantinos N AU - Fountoulakis KN AUID- ORCID: 0000-0001-5503-0811 AD - 3rd Department of Psychiatry, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, Thessaloniki, Greece. LA - eng PT - Journal Article PL - United Arab Emirates TA - Curr Neuropharmacol JT - Current neuropharmacology JID - 101157239 SB - IM MH - Humans MH - Female MH - *Chronotype MH - Greece/epidemiology MH - *Students/psychology MH - Cross-Sectional Studies MH - *Emotional Regulation/physiology MH - Young Adult MH - Universities MH - *Bulimia/psychology MH - Surveys and Questionnaires MH - Adult MH - Adolescent MH - Feeding Behavior/psychology MH - Circadian Rhythm PMC - PMC13647652 OTO - NOTNLM OT - Binge eating behaviors OT - chronotypes OT - circadian rhythm OT - eating disorders OT - emotion regulation OT - evening chronotype COIS- The authors declare no conflict of interest, financial or otherwise. EDAT- 2026/01/23 06:31 MHDA- 2026/09/24 05:36 PMCR- 2026/07/13 CRDT- 2026/01/23 02:08 PHST- 2025/07/21 00:00 [received] PHST- 2025/09/28 00:00 [revised] PHST- 2025/10/07 00:00 [accepted] PHST- 2026/09/24 05:36 [medline] PHST- 2026/01/23 06:31 [pubmed] PHST- 2026/01/23 02:08 [entrez] PHST- 2026/07/13 00:00 [pmc-release] AID - CN-EPUB-152577 [pii] AID - CN-24-11-1765 [pii] AID - 10.2174/011570159X431924251127110942 [doi] PST - ppublish SO - Curr Neuropharmacol. 2026;24(11):1765-1776. doi: 10.2174/011570159X431924251127110942. PMID- 41572317 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260813 IS - 1746-4358 (Electronic) IS - 1746-4358 (Linking) VI - 21 IP - 1 DP - 2026 Jan 22 TI - Psychometric evaluation of the Chinese version of the exclusive breastfeeding social support scale: a cross-sectional study. PG - 20 LID - 10.1186/s13006-026-00814-z [doi] LID - 20 AB - BACKGROUND: Exclusive breastfeeding (EBF) contributes significantly to the physical and psychological health of both mothers and infants. Social support is a critical factor in maintaining EBF. However, there is a lack of validated instruments to assess the level of social support for EBF in China. To address this gap, this study aimed to translate the Exclusive Breastfeeding Social Support Scale (EBFSS) into Chinese and evaluate its reliability and validity. METHODS: The EBFSS was translated using the Brislin method and cross-culturally adapted. An expert panel review and a pre-survey were conducted to finalize the Chinese version. This cross-sectional study recruited 479 exclusively breastfeeding mothers between January and April 2025 through convenience sampling at four community hospitals in Hefei City. Validity was assessed using content validity, construct validity, convergent validity, discriminant validity, and criterion-related validity. Reliability was evaluated using Cronbach's alpha coefficient, McDonald's omega coefficient, split-half reliability, and test-retest reliability. RESULTS: The Chinese version of the EBFSS consisted of 16 items across three dimensions: emotional, informational, and instrumental support. A total of 29 incomplete questionnaires were excluded, resulting in 450 valid responses for psychometric testing. The content validity of the items and scale levels ranged from 0.800 to 1.000 and 0.988, respectively; exploratory factor analysis (EFA) extracted three common factors with a cumulative variance contribution of 69.539%; confirmatory factor analysis (CFA) showed a good model fit (chi(2)/DF = 1.914, RMSEA = 0.064, CFI = 0.960, GFI = 0.907, TLI = 0.952, IFI = 0.960, TLI = 0.952). Correlation-related validity was 0.857 (p < 0.001). Cronbach's alpha coefficient was 0.931, McDonald's omega coefficient was 0.929, test-retest reliability was 0.936, and split-half reliability was 0.882. CONCLUSION: The Chinese version of the EBFSS demonstrates good reliability and validity and can be used to assess social support among mothers who exclusively breastfeed. This tool provides a scientific foundation for future study and targeted interventions aimed at improving EBF outcomes in China. CI - (c) 2026. The Author(s). FAU - Gao, Jilin AU - Gao J AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. FAU - Wang, Wenyan AU - Wang W AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. FAU - Wei, Bing AU - Wei B AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. FAU - Ling, Qiaoyun AU - Ling Q AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. FAU - Hu, Wenqi AU - Hu W AD - Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China. 18655613692@163.com. LA - eng GR - JF20234922/Natural Science Foundation of Anhui Province/ PT - Journal Article DEP - 20260122 PL - England TA - Int Breastfeed J JT - International breastfeeding journal JID - 101251562 SB - IM MH - Humans MH - *Social Support MH - Cross-Sectional Studies MH - *Breast Feeding/psychology MH - *Psychometrics MH - China MH - Reproducibility of Results MH - Female MH - Surveys and Questionnaires/standards MH - Adult MH - *Mothers/psychology MH - Young Adult PMC - PMC12910969 OTO - NOTNLM OT - Exclusive breastfeeding OT - Postpartum woman OT - Reliability OT - Social support OT - Validity COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Ethics Committee of the Second Affiliated Hospital of Anhui Medical University (Approval No: YX2025-133), and written informed consent was obtained from all participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/23 00:26 MHDA- 2026/02/17 06:31 PMCR- 2026/01/22 CRDT- 2026/01/22 23:52 PHST- 2025/06/23 00:00 [received] PHST- 2026/01/14 00:00 [accepted] PHST- 2026/02/17 06:31 [medline] PHST- 2026/01/23 00:26 [pubmed] PHST- 2026/01/22 23:52 [entrez] PHST- 2026/01/22 00:00 [pmc-release] AID - 10.1186/s13006-026-00814-z [pii] AID - 814 [pii] AID - 10.1186/s13006-026-00814-z [doi] PST - epublish SO - Int Breastfeed J. 2026 Jan 22;21(1):20. doi: 10.1186/s13006-026-00814-z. PMID- 41572177 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-2474 (Electronic) IS - 1471-2474 (Linking) VI - 27 IP - 1 DP - 2026 Jan 22 TI - Correlation between systemic immune inflammatory index and prognostic nutritional index and prognosis of osteosarcoma patients and construction of prediction model. PG - 151 LID - 10.1186/s12891-026-09494-6 [doi] LID - 151 AB - BACKGROUND: To explore the predictive value of systemic immune inflammatory index (SII) and prognostic nutritional index (PNI) for the prognosis of patients with osteosarcoma, and to construct and validate an individualized survival prediction model. METHODS: The clinical data of osteosarcoma patients who underwent surgery in the 900th Hospital of the Joint Logistics Support Force from January 2012 to January 2020 were retrospectively analyzed. Preoperative SII (platelets x neutrophils/lymphocytes) and PNI (albumin + 5 x lymphocytes) were calculated, and the optimal cutoff values​were determined by ROC curve. The Kaplan-Meier method was used to draw survival curves to analyze their relationship with the overall survival time of patients. Pearson correlation analysis was used to analyze the correlation between SII and PNI. Cox regression analysis was used to analyze independent prognostic factors, and the nomogram model was constructed using R software and internally validated. RESULTS: The 5-year overall survival rate of the high SII group was significantly lower than that of the low SII group (27.7% vs. 87.0%, p < 0.05); the 5-year overall survival rate of the low PNI group was significantly lower than that of the high PNI group (23.1% vs. 83.6%, p < 0.05). SII was negatively correlated with PNI (r=-0.410, P < 0.001). The high SII + low PNI group had the worst prognosis, while the low SII + high PNI group had the best prognosis. Cox multivariate analysis showed that SII > 552.60, PNI /=60 ml/min per 1.73 m 2 . Predictor variables in the base model were age, sex, creatinine or eGFR, ADPKD genotype, and Mayo Imaging Class. Clinical and laboratory data were evaluated in the full model. RESULTS: The development cohort included 759 patients with baseline eGFR of 91+/-29 ml/min per 1.73 m 2 (mean+/-SD), of whom 16% reached end point after median (interquartile range) follow-up of 10.2 (5.5-16.7) years. The validation cohort included 535 patients with baseline eGFR of 90+/-31 ml/min per 1.73 m 2 (mean+/-SD), of whom 11% reached end point after median (interquartile range) follow-up of 5.5 (1.5-13.7) years. The full model, including age, sex, serum creatinine, Mayo Imaging Class, total carbon dioxide, hemoglobin, diastolic BP, and body mass index, had a C-index of 0.81 (95% confidence interval, 0.72 to 0.90) in the validation cohort and 0.75 (95% confidence interval, 0.62 to 0.88) when ADPKD genotype was also included. Risk predictions from base and full models were well-calibrated out to 15 years. CONCLUSIONS: In persons with early ADPKD and preserved eGFR, a model using routinely obtained clinical information quantified risk of kidney failure over 15 years. CI - Copyright (c) 2025 by the American Society of Nephrology. FAU - Yu, Alan S L AU - Yu ASL AUID- ORCID: 0000-0002-1776-2533 AD - Division of Nephrology and Hypertension and the Jared Grantham Kidney Institute, University of Kansas Medical Center, Kansas City, Kansas. FAU - Cohen, Aaron AU - Cohen A AD - Department of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, Indiana. FAU - Torres, Vicente E AU - Torres VE AD - Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota. FAU - Chebib, Fouad T AU - Chebib FT AUID- ORCID: 0000-0002-3949-5720 AD - Division of Nephrology, Mayo Clinic, Jacksonville, Florida. FAU - Landsittel, Douglas P AU - Landsittel DP AD - Department of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, Indiana. AD - Department of Biostatistics, University at Buffalo, The State University of New York, New York, New York. FAU - Chapman, Arlene B AU - Chapman AB AD - Division of Nephrology, University of Chicago School of Medicine, Chicago, Illinois. FAU - Mrug, Michal AU - Mrug M AD - Division of Nephrology, University of Alabama and the Department of Veterans Affairs Medical Center, Birmingham, Alabama. FAU - Harris, Peter C AU - Harris PC AUID- ORCID: 0000-0002-5304-6593 AD - Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota. FAU - Rahbari-Oskoui, Frederic F AU - Rahbari-Oskoui FF AD - Department of Internal Medicine, Emory University School of Medicine, Atlanta, Georgia. FAU - Ables, Erin AU - Ables E AUID- ORCID: 0000-0001-8617-6768 AD - Department of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, Indiana. FAU - Parker, Chelsie AU - Parker C AUID- ORCID: 0000-0001-5262-9693 AD - Department of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, Indiana. FAU - Munairdjy Debeh, Fadi George AU - Munairdjy Debeh FG AUID- ORCID: 0009-0001-0581-1211 AD - Division of Nephrology, Mayo Clinic, Jacksonville, Florida. FAU - Chedid, Maroun AU - Chedid M AD - Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota. FAU - Elbarougy, Doaa AU - Elbarougy D AUID- ORCID: 0009-0000-6487-8312 AD - Division of Nephrology and Hypertension, Mayo Clinic, Rochester, Minnesota. FAU - Bae, Kyongtae Ty AU - Bae KT AUID- ORCID: 0000-0002-6304-4890 AD - Department of Diagnostic Radiology, University of Hong Kong, Pok Fu Lam, Hong Kong. FAU - Bennett, William M AU - Bennett WM AD - Legacy Good Samaritan Hospital, Portland, Oregon. LA - eng GR - R01 DK113111/DK/NIDDK NIH HHS/United States GR - R01 DK142878/DK/NIDDK NIH HHS/United States GR - U54 DK126126/DK/NIDDK NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20251203 PL - United States TA - J Am Soc Nephrol JT - Journal of the American Society of Nephrology : JASN JID - 9013836 SB - IM CIN - doi: 10.1681/ASN.0000001074 MH - Humans MH - *Polycystic Kidney, Autosomal Dominant/complications/genetics MH - Female MH - Disease Progression MH - Middle Aged MH - Male MH - Adult MH - Glomerular Filtration Rate MH - Prognosis MH - Adolescent MH - *Renal Insufficiency/etiology MH - Young Adult MH - Proportional Hazards Models MH - Multivariate Analysis MH - Prediction Algorithms PMC - PMC13143440 OTO - NOTNLM OT - CKD nondialysis OT - epidemiology and outcomes OT - polycystic kidney disease OT - prediction modeling COIS- Disclosure forms, as provided by each author, are available with the online version of the article at http://links.lww.com/JSN/F561. EDAT- 2026/01/21 12:58 MHDA- 2026/05/01 12:37 PMCR- 2026/05/01 CRDT- 2026/01/21 10:33 PHST- 2025/04/02 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2026/05/01 12:37 [medline] PHST- 2026/01/21 12:58 [pubmed] PHST- 2026/01/21 10:33 [entrez] PHST- 2026/05/01 00:00 [pmc-release] AID - 00001751-202605000-00012 [pii] AID - JASN-2025-000431 [pii] AID - 10.1681/ASN.0000000950 [doi] PST - ppublish SO - J Am Soc Nephrol. 2026 May 1;37(5):1010-1021. doi: 10.1681/ASN.0000000950. Epub 2025 Dec 3. PMID- 41562757 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260121 LR - 20260328 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 11 IP - 1 DP - 2026 Jan 18 TI - The Health and Physical Education Curriculum: Does It Address Muscular Fitness? LID - 10.3390/jfmk11010040 [doi] LID - 40 AB - Background: The World Health Organization and the Australian physical activity guidelines, in line with contemporary research, recommend regular muscle-strengthening activities for optimal muscular fitness in children and adolescents. However, the extent to which muscle-strengthening or muscular fitness receives curricular emphasis is unknown in Australia. Objectives: To examine to what extent the Australian Health and Physical Education Curriculum, Foundation to Year 10 (AHPEC; F-10) addresses and/or promotes muscular fitness. Methods: This study involved a mixed-methods content analysis of the AHPEC F-10 using: (i) conceptual analysis to identify muscular fitness-related terms; and (ii) relational analysis to examine alignment between muscular fitness content and curriculum rationale/aims. A search of national and international physical activity guidelines and school-based muscular fitness intervention literature generated a keyword set to guide abstraction from the AHPEC. Curriculum aim, rationale, level descriptions, achievement standards and content were coded to determine the extent to which muscular fitness was embedded. Intercoder reliability was established via consensus meetings. Muscular fitness content coverage was quantified as the proportion of directly aligned muscular fitness relevant content points per stage and aggregated primary (F-6), secondary (7-10), and F-10 scores. Results: A review of 32 national and one international physical activity guidelines identified 88 muscular fitness activities in total, with some activities appearing in multiple guidelines; 53.1% of national guidelines did not provide explicit muscular fitness examples, and where examples existed, they emphasised accessible modes (e.g., climbing, bodyweight tasks, jumping, and lifting). Additionally, analysis of school-based muscular fitness intervention literature identified 22 distinct muscular fitness activities to guide abstraction. Muscular fitness was absent in the AHPEC rationale and aims, was largely inferred in primary years level description and achievement standards and became more explicit in secondary achievement standards. Direct alignment of content with muscular fitness was non-existent or low across stages of learning (Foundation = 0%, Stage 1 = 0%, Stage 2 = 6.1%, Stage 3 = 9.1%, Stage 4 = 8.6%, Stage 5 = 8.8%). Overall, muscular fitness content coverage averaged 3.8% in primary, 8.7% in secondary, and 5.4% across F-10. Conclusions: The AHPEC treats muscular fitness as a low priority in primary schooling and a minor content area in secondary, yielding developmental messaging that is less aligned with contemporary evidence and physical activity guidelines. FAU - Sortwell, Andrew AU - Sortwell A AUID- ORCID: 0000-0001-9987-5939 AD - School of Education, The University of Notre Dame Australia, Sydney 2007, Australia. AD - School of Health Sciences, The University of Notre Dame Australia, Fremantle 6160, Australia. AD - Research Centre in Sports Sciences, Health Sciences and Human Development (CIDESD), University of Beira Interior, 6201-001 Covilha, Portugal. FAU - Ramirez-Campillo, Rodrigo AU - Ramirez-Campillo R AUID- ORCID: 0000-0003-2035-3279 AD - Exercise and Rehabilitation Sciences Institute, Faculty of Rehabilitation Sciences, Universidad Andres Bello, Santiago 7591538, Chile. AD - Sport Sciences and Human Performance Laboratories, Instituto de Alta Investigacion, Universidad de Tarapaca, Arica 1010069, Chile. AD - Department of Physical Activity Sciences, Universidad de Los Lagos, Santiago 8320000, Chile. FAU - Granacher, Urs AU - Granacher U AUID- ORCID: 0000-0002-7095-813X AD - Department of Sport and Sport Science, Exercise and Human Movement Science, University of Freiburg, 79102 Freiburg, Germany. FAU - Joyce, Christopher AU - Joyce C AUID- ORCID: 0000-0003-0990-0876 AD - School of Health Sciences, The University of Notre Dame Australia, Fremantle 6160, Australia. FAU - Forte, Pedro AU - Forte P AUID- ORCID: 0000-0003-0184-6780 AD - Department of Sports, Higher Institute of Educational Sciences of the Douro, 4560-708 Penafiel, Portugal. AD - Department of Sports Sciences, Instituto Politecnico de Braganca, 5300-253 Braganca, Portugal. AD - Research Centre for Active Living and Wellbeing (Livewell), Instituto Politecnico de Braganca, 5300-253 Braganca, Portugal. FAU - Marinho, Daniel A AU - Marinho DA AUID- ORCID: 0000-0003-2351-3047 AD - Research Centre in Sports Sciences, Health Sciences and Human Development (CIDESD), University of Beira Interior, 6201-001 Covilha, Portugal. AD - Department of Sports Sciences, University of Beira Interior, 6201-001 Covilha, Portugal. FAU - Ferraz, Ricardo AU - Ferraz R AUID- ORCID: 0000-0002-7530-512X AD - Research Centre in Sports Sciences, Health Sciences and Human Development (CIDESD), University of Beira Interior, 6201-001 Covilha, Portugal. AD - Department of Sports Sciences, University of Beira Interior, 6201-001 Covilha, Portugal. FAU - Trimble, Kevin AU - Trimble K AUID- ORCID: 0000-0001-9748-8185 AD - School of Education, The University of Notre Dame Australia, Sydney 2007, Australia. LA - eng PT - Journal Article DEP - 20260118 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC12821546 OTO - NOTNLM OT - adolescent health OT - child health OT - muscle strength OT - physical education OT - resistance training COIS- The authors declare no conflicts of interest. EDAT- 2026/01/21 13:00 MHDA- 2026/01/21 13:01 PMCR- 2026/01/18 CRDT- 2026/01/21 09:25 PHST- 2025/11/14 00:00 [received] PHST- 2025/12/20 00:00 [revised] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/01/21 13:01 [medline] PHST- 2026/01/21 13:00 [pubmed] PHST- 2026/01/21 09:25 [entrez] PHST- 2026/01/18 00:00 [pmc-release] AID - jfmk11010040 [pii] AID - jfmk-11-00040 [pii] AID - 10.3390/jfmk11010040 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2026 Jan 18;11(1):40. doi: 10.3390/jfmk11010040. PMID- 41562743 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260121 LR - 20260328 IS - 2411-5142 (Electronic) IS - 2411-5142 (Linking) VI - 11 IP - 1 DP - 2026 Jan 1 TI - EXcellence and PERformance in Track and Field (EXPERT)-A Mixed-Longitudinal Study on Growth, Biological Maturation, Performance, and Health in Young Athletes: Rationale, Design, and Methods (Part 1). LID - 10.3390/jfmk11010025 [doi] LID - 25 AB - This paper presents the rationale and design of a study of growth and development in young track and field athletes: the EXcellence and PERformance in Track and field (EXPERT) study, and details the methodologies used. Background: Longitudinal research examining individual-environment interactions in youth athletic development is scarce for track and field. Objectives: The EXPERT study investigates how individual (anthropometry, maturation, motivation) and environmental (family, coach, club) characteristics influence developmental trajectories in youth track and field athletes. Methods: A mixed-longitudinal design will follow 400 athletes (200male symbol, 200female symbol; aged 10-14 years) from 40 Portuguese clubs across five cohorts assessed biannually over three years. Guided by Bronfenbrenner's bioecological model, assessments encompass individual, performance, health, and environmental domains. Data quality control will consist of rigorous training of all research team members, implementation of standardized protocols, a pilot study, and an in-field reliability study. Multilevel growth models will examine trajectories and predictor effects of predictors. Conclusions: EXPERT will provide evidence to optimize training and support holistic youth athlete development. FAU - Ribeiro, Teresa AU - Ribeiro T AD - Centre of Research, Education, Innovation and Intervention in Sport (CIFI2D), Faculty of Sport, University of Porto, 4200-450 Porto, Portugal. FAU - Maia, Jose AU - Maia J AUID- ORCID: 0000-0002-3273-0046 AD - Centre of Research, Education, Innovation and Intervention in Sport (CIFI2D), Faculty of Sport, University of Porto, 4200-450 Porto, Portugal. FAU - Conceicao, Filipe AU - Conceicao F AUID- ORCID: 0000-0002-1636-2685 AD - Centre of Research, Education, Innovation and Intervention in Sport (CIFI2D), Faculty of Sport, University of Porto, 4200-450 Porto, Portugal. FAU - Baxter-Jones, Adam D G AU - Baxter-Jones ADG AUID- ORCID: 0000-0003-0430-0556 AD - College of Kinesiology, University of Saskatchewan, Saskatoon, SK S7N 5B5, Canada. FAU - Guimaraes, Eduardo AU - Guimaraes E AUID- ORCID: 0000-0001-5344-9344 AD - Centre of Research, Education, Innovation and Intervention in Sport (CIFI2D), Faculty of Sport, University of Porto, 4200-450 Porto, Portugal. FAU - Vasconcelos, Olga AU - Vasconcelos O AUID- ORCID: 0000-0003-4505-0653 AD - Centre of Research, Education, Innovation and Intervention in Sport (CIFI2D), Faculty of Sport, University of Porto, 4200-450 Porto, Portugal. FAU - Dias, Claudia AU - Dias C AUID- ORCID: 0000-0003-0418-0056 AD - Centre of Research, Education, Innovation and Intervention in Sport (CIFI2D), Faculty of Sport, University of Porto, 4200-450 Porto, Portugal. FAU - Santos, Carla AU - Santos C AD - Centre of Research, Education, Innovation and Intervention in Sport (CIFI2D), Faculty of Sport, University of Porto, 4200-450 Porto, Portugal. AD - Center for Sport, Physical Education, Exercise and Health, CIDEFES, Universidade Lusofona, 1749-024 Lisbon, Portugal. FAU - Paulo, Ana AU - Paulo A AUID- ORCID: 0000-0002-9556-599X AD - Center for Sport, Physical Education, Exercise and Health, CIDEFES, Universidade Lusofona, 1749-024 Lisbon, Portugal. FAU - Aleixo, Pedro AU - Aleixo P AUID- ORCID: 0000-0002-7641-5128 AD - Center for Sport, Physical Education, Exercise and Health, CIDEFES, Universidade Lusofona, 1749-024 Lisbon, Portugal. FAU - Pinto, Pedro AU - Pinto P AD - Center for Sport, Physical Education, Exercise and Health, CIDEFES, Universidade Lusofona, 1749-024 Lisbon, Portugal. FAU - Teixeira, Diogo AU - Teixeira D AUID- ORCID: 0000-0003-4587-5903 AD - Center for Sport, Physical Education, Exercise and Health, CIDEFES, Universidade Lusofona, 1749-024 Lisbon, Portugal. FAU - Massuca, Luis Miguel AU - Massuca LM AUID- ORCID: 0000-0001-8786-3498 AD - Centre of Research, Education, Innovation and Intervention in Sport (CIFI2D), Faculty of Sport, University of Porto, 4200-450 Porto, Portugal. AD - Center for Sport, Physical Education, Exercise and Health, CIDEFES, Universidade Lusofona, 1749-024 Lisbon, Portugal. AD - Police Research Center, Higher Institute of Police Sciences and Homeland Security, IPCOL, 1349-040 Lisbon, Portugal. FAU - Pereira, Sara AU - Pereira S AUID- ORCID: 0000-0002-4661-3879 AD - Centre of Research, Education, Innovation and Intervention in Sport (CIFI2D), Faculty of Sport, University of Porto, 4200-450 Porto, Portugal. LA - eng PT - Journal Article DEP - 20260101 PL - Switzerland TA - J Funct Morphol Kinesiol JT - Journal of functional morphology and kinesiology JID - 101712257 PMC - PMC12821680 OTO - NOTNLM OT - bioecological model OT - biological maturation OT - mixed-longitudinal design OT - motor performance OT - track and field OT - youth athletes COIS- The authors declare no conflicts of interest. EDAT- 2026/01/21 12:59 MHDA- 2026/01/21 13:00 PMCR- 2026/01/01 CRDT- 2026/01/21 09:25 PHST- 2025/10/27 00:00 [received] PHST- 2025/12/29 00:00 [revised] PHST- 2025/12/30 00:00 [accepted] PHST- 2026/01/21 13:00 [medline] PHST- 2026/01/21 12:59 [pubmed] PHST- 2026/01/21 09:25 [entrez] PHST- 2026/01/01 00:00 [pmc-release] AID - jfmk11010025 [pii] AID - jfmk-11-00025 [pii] AID - 10.3390/jfmk11010025 [doi] PST - epublish SO - J Funct Morphol Kinesiol. 2026 Jan 1;11(1):25. doi: 10.3390/jfmk11010025. PMID- 41561253 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260121 LR - 20260123 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 12 DP - 2025 Dec TI - Pituitary Imaging: Indications and Outcomes From a Tertiary Pediatric Center in the United Arab Emirates. PG - e99675 LID - 10.7759/cureus.99675 [doi] LID - e99675 AB - INTRODUCTION: The pituitary gland plays a critical role in regulating endocrine function, with disorders manifesting as diverse clinical and laboratory abnormalities. Magnetic resonance imaging (MRI) of the Sella turcica provides a detailed anatomical evaluation, supporting the diagnosis of pituitary pathologies, particularly growth hormone deficiency (GHD) and precocious puberty (PP). OBJECTIVES: To describe the clinical, laboratory, and MRI characteristics of pediatric patients undergoing pituitary MRI at a tertiary pediatric center in the United Arab Emirates, and to estimate the diagnostic yield of MRI, defined as the frequency and pattern of structural pituitary abnormalities, across major endocrine indications. METHODOLOGY: We conducted a retrospective review of 205 pediatric patients who underwent MRI Sella at Al Jalila Children's Hospital, a major tertiary/quaternary pediatric hospital in Dubai, UAE, between January 2023 and June 2024. Data collected included demographics, auxological measurements (height, weight, BMI, bone age), laboratory results, and imaging findings. RESULTS: The cohort comprised 205 patients (130 (63.4%) male, mean age 10.0 years). Suspected GHD was the most common indication for MRI (165 patients, 80%), with 116 (56.5%) later confirmed. Pituitary hypoplasia was observed in 63 (54%) patients with GHD, while pituitary hyperplasia was noted in 5 (30%) cases of PP. Lesions such as Rathke's cleft cysts (9, 4.4%) and interrupted pituitary stalk (5, 2.4%) were identified, predominantly in patients with GHD. CONCLUSIONS: MRI sella provides anatomical characterization of the pituitary gland in children undergoing endocrine evaluation and demonstrates a range of structural findings, particularly among those with confirmed GHD. A comprehensive diagnostic approach combining imaging, auxological, and biochemical data enhances diagnostic accuracy. CI - Copyright (c) 2025, Sabsabee et al. FAU - Sabsabee, Mohamad AU - Sabsabee M AD - Pediatrics, Al Jalila Children's Speciality Hospital, Dubai, ARE. FAU - Ghanim, Reham AU - Ghanim R AD - Pediatric Endocrinology, Glucare Integrated Diabetes and Endocrinology Center, Dubai, ARE. FAU - Prashanth, Ajay AU - Prashanth A AD - Diagnostic Radiology, Al Jalila Children's Speciality Hospital, Dubai, ARE. FAU - El Abiary, Mohammad AU - El Abiary M AD - Pediatric Endocrinology, Al Jalila Children's Speciality Hospital, Dubai, ARE. FAU - Thalange, Nandu AU - Thalange N AD - Pediatric Endocrinology, Genesis Healthcare, Dubai, ARE. LA - eng PT - Journal Article DEP - 20251219 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12813504 OTO - NOTNLM OT - growth hormone deficiency OT - pituitary gland OT - pituitary mri OT - precocious puberty (pp) OT - short stature (ss) COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Mohammed Bin Rashid University Institutional Review Board (MBRU-IRB) issued approval MBRU IRB-2024-118. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/01/21 06:31 MHDA- 2026/01/21 06:32 PMCR- 2025/12/19 CRDT- 2026/01/21 04:57 PHST- 2025/12/19 00:00 [accepted] PHST- 2026/01/21 06:32 [medline] PHST- 2026/01/21 06:31 [pubmed] PHST- 2026/01/21 04:57 [entrez] PHST- 2025/12/19 00:00 [pmc-release] AID - 10.7759/cureus.99675 [doi] PST - epublish SO - Cureus. 2025 Dec 19;17(12):e99675. doi: 10.7759/cureus.99675. eCollection 2025 Dec. PMID- 41560369 OWN - NLM STAT- MEDLINE DCOM- 20260616 LR - 20260811 IS - 1527-330X (Electronic) IS - 1090-820X (Linking) VI - 46 IP - 7 DP - 2026 Jun 16 TI - Analysis of Bicorticality in a Cohort of Post-RibXcar Patients: A Clinical and Imaging Follow-up Study. PG - 737-744 LID - 10.1093/asj/sjag012 [doi] AB - BACKGROUND: RibXcar is a minimally invasive technique for waistline contouring that uses ultrasound-guided monocortical rib fractures to achieve controlled angulation while preserving thoracic stability. Although its safety profile is favorable, bicorticalization fracture extension through both cortices remains a potential complication requiring systematic evaluation. OBJECTIVES: This study aimed to assess the incidence, clinical evolution, and radiologic characteristics of bicorticality in a prospective cohort of RibXcar patients. METHODS: A prospective cohort of 328 female patients (mean age 28.3 +/- 6.7 years; BMI 25.3 +/- 1.8 kg/m(2)) underwent RibXcar between January and December 2023, performed by a single surgeon. Eligible patients were women aged 18-40 years with BMI < 30 kg/m(2) and visceral fat < 13%. All completed 1-year clinical and radiologic follow-up. Postoperative pain, complications, and imaging findings were analyzed using Wilcoxon tests (P < .05). RESULTS: Bicorticality occurred in 15 patients (4.6%), mostly within the first 20 postoperative days. Pain was reported by 41 patients (12.5%), but in 7.9% was related to corset misuse rather than fracture status. Bicorticality correlated with higher visceral fat (12.7% +/- 0.5 vs 8.0% +/- 0.3; P < .001) and longer operative time (48.9 +/- 6.3 vs 43.3 +/- 8.3 minutes; P = .01). No hemothorax or pneumothorax occurred. At 1 year, 98.2% demonstrated satisfactory healing; 1.5% showed callus irregularity; and only 1 patient (0.3%) had persistent bicorticality. CONCLUSIONS: RibXcar achieves controlled monocortical fractures with a low bicorticalization rate and predictable consolidation. Visceral fat and operative duration appear more influential than BMI in complication risk, supporting the technique's safety and reproducibility. LEVEL OF EVIDENCE: 4 (THERAPEUTIC): For image description, please refer to the figure legend and surrounding text. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of The Aesthetic Society. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Manzaneda Cipriani, Raul M AU - Manzaneda Cipriani RM AUID- ORCID: 0000-0003-1359-2298 FAU - Duran, Hector AU - Duran H AUID- ORCID: 0000-0003-3399-6302 FAU - Adrianzen, Gerardo A AU - Adrianzen GA FAU - Flores, Emmanuel AU - Flores E FAU - Romero Algara, Enrique AU - Romero Algara E FAU - Mendoza Guerra, Cynthia AU - Mendoza Guerra C LA - eng PT - Journal Article PL - England TA - Aesthet Surg J JT - Aesthetic surgery journal JID - 9707469 SB - IM MH - Humans MH - Female MH - Adult MH - Young Adult MH - Prospective Studies MH - Follow-Up Studies MH - Adolescent MH - *Rib Fractures/surgery/diagnostic imaging MH - *Body Contouring/methods/adverse effects MH - Postoperative Pain/etiology/epidemiology MH - *Postoperative Complications/epidemiology/etiology MH - Ultrasonography, Interventional/methods MH - Treatment Outcome EDAT- 2026/01/21 06:31 MHDA- 2026/06/16 06:35 CRDT- 2026/01/21 01:44 PHST- 2026/01/08 00:00 [accepted] PHST- 2026/06/16 06:35 [medline] PHST- 2026/01/21 06:31 [pubmed] PHST- 2026/01/21 01:44 [entrez] AID - 8432383 [pii] AID - 10.1093/asj/sjag012 [doi] PST - ppublish SO - Aesthet Surg J. 2026 Jun 16;46(7):737-744. doi: 10.1093/asj/sjag012. PMID- 41560031 OWN - NLM STAT- MEDLINE DCOM- 20260121 LR - 20260124 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 3 DP - 2026 Jan 16 TI - Effects of exercise intervention on inhibitory control in children and adolescents with autism spectrum disorders: A systematic review and meta-analysis. PG - e47186 LID - 10.1097/MD.0000000000047186 [doi] LID - e47186 AB - BACKGROUND: Exercise interventions have a positive impact on executive functioning in children and adolescents with autism spectrum disorders (ASD), but the efficacy of inhibitory control (IC) following exercise interventions is unclear. The aim was to investigate the effects of an exercise intervention on IC function in children and adolescents with ASD and to explore the underlying mechanisms. METHODS: We searched 8 English (Web of Science, PubMed, Scopus, Embase, MEDLINE, SPORTDiscus, Cochrane Library, and APA PsycINFO) and 2 Chinese databases (China Biomedical and CNKI) up to November 2024. Two authors independently extracted data, assessed bias with Cochrane Risk of Bias 2 tool, and graded evidence with Grading of Recommendations, Assessment, Development and Evaluation. Eighteen studies were included, of which 8 entered the meta-analysis. RESULTS: Overall, the combined effect of exercise intervention on IC in children and adolescents with ASD was statistically significant in the intervention group compared to the control group (standardized mean difference = -0.49, 95% confidence interval [-0.72 to -0.26], Z = 4.16, P < .0001), with no heterogeneity (I2 = 0%), and no publication bias was found by funnel plots and Egger test, sensitivity analysis revealed no publication bias, and the findings were stable. Subgroup analysis revealed that, in terms of movement patterns, martial arts interventions appeared to be more effective in enhancing IC, while ball sports and combined sports did not show significant effects. Interventions with shorter session durations (2), and shorter intervention cycles (/= 18 years in Al-Baha. Participants completed a validated, self-administered online questionnaire covering demographics, lifestyle behaviors, and health status. body mass index was calculated from self-reported height and weight. Lifestyle quality was scored and categorized. Data were analyzed using SPSS v26 with descriptive statistics and chi-square tests. Of the 1008 participants, 651 (64.6%) were males and 357 (35.4%) were females. Notably, obesity prevalence was higher among females (97, 27.2%) than males (92, 14.1%). The highest rate occurred in the 45 to 54-year-old age group (60, 35.7%). Obesity was observed in 119 (19.2%) university graduates and 10 (12.6%) postgraduates. Married participants (143, 22.7%) had a higher obesity rate than singles (40, 11.4%). A total of 114 (11.3%) were sedentary, and 54 (5.4%) consumed fast food daily. Most participants (740, 73.4%) had a fair lifestyle score, while only 11 (1.1%) reported excellent habits. Obesity was significantly associated with gender, age, marital status, education, occupation, and lifestyle score (P < .05). Obesity is highly prevalent in Al-Baha, particularly among women and middle-aged adults. The findings underscore the urgent need for targeted local programs promoting physical activity, healthier diets, and lifestyle education. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Agwa, Ramy H AU - Agwa RH AUID- ORCID: 0000-0003-3207-7486 AD - Department of Internal Medicine, Faculty of Medicine, Al-Baha University, Al-Baha, Saudi Arabia. AD - Hepatology and Gastroenterology Unit, Internal Medicine Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt. FAU - Alkully, Turki H AU - Alkully TH AUID- ORCID: 0009-0009-7291-3216 AD - Department of Internal Medicine, Faculty of Medicine, Al-Baha University, Al-Baha, Saudi Arabia. FAU - Alghamdi, Twfiq A AU - Alghamdi TA AUID- ORCID: 0009-0009-5082-2305 AD - Al-Baha University, Al-Baha, Saudi Arabia. FAU - Alghamdi, Rami F AU - Alghamdi RF AD - Al-Baha University, Al-Baha, Saudi Arabia. FAU - Alzahrani, Ayman M AU - Alzahrani AM AD - Al-Baha University, Al-Baha, Saudi Arabia. FAU - Alghamdi, Waleed S AU - Alghamdi WS AD - Al-Baha University, Al-Baha, Saudi Arabia. FAU - Alomari, Abdulaziz M AU - Alomari AM AD - Al-Baha University, Al-Baha, Saudi Arabia. FAU - Alghamdi, Adel A AU - Alghamdi AA AD - Al-Baha University, Al-Baha, Saudi Arabia. FAU - Alghamdi, Abdulhakeem A AU - Alghamdi AA AD - Al-Baha University, Al-Baha, Saudi Arabia. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - Male MH - Cross-Sectional Studies MH - Middle Aged MH - *Obesity/epidemiology MH - *Life Style MH - Prevalence MH - Female MH - Adult MH - Body Mass Index MH - Surveys and Questionnaires MH - Young Adult MH - Exercise MH - Adolescent MH - Aged PMC - PMC12826265 OTO - NOTNLM OT - Saudi Arabia OT - body mass index OT - lifestyle behaviors OT - obesity OT - public health COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2026/01/21 06:31 MHDA- 2026/01/21 06:32 PMCR- 2026/01/16 CRDT- 2026/01/21 01:03 PHST- 2025/09/07 00:00 [received] PHST- 2025/12/01 00:00 [accepted] PHST- 2026/01/21 06:32 [medline] PHST- 2026/01/21 06:31 [pubmed] PHST- 2026/01/21 01:03 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - 00005792-202601160-00058 [pii] AID - MD-D-25-11718 [pii] AID - 10.1097/MD.0000000000047038 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jan 16;105(3):e47038. doi: 10.1097/MD.0000000000047038. PMID- 41559179 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jan 21 TI - Knowledge of cardiovascular diseases among university students in Egypt. PG - 2637 LID - 10.1038/s41598-025-34137-6 [doi] LID - 2637 AB - Cardiovascular diseases (CVDs) are the leading cause of death worldwide. Promoting early awareness and understanding of modifiable risk factors among young people is crucial for prevention. Yet, little is known about the level of awareness among university students in Egypt. This study aimed to evaluate university students' knowledge of cardiovascular diseases (CVDs) and their associated risk factors, with a focus on general awareness, scientific understanding, and behavioral responses related to cardiovascular health. A cross-sectional analytical study was carried out among 300 university students using a pre-validated English questionnaire administered through Google forms. Participants were recruited from seven faculties at Pharos University. The questionnaire evaluated students' knowledge of CVD risk factors and their overall awareness of cardiovascular conditions. The study revealed significantly higher knowledge scores among female participants (15.3 +/- 2.6) compared to males (13.8 +/- 4.0), (p = 0.007). The Faculty of Dentistry had the highest mean knowledge score (15.6 +/- 3.1), with a significant decline in knowledge observed among students from applied sciences and engineering/arts (p = 0.04 and 0.002, respectively). While no significant differences were found between dentistry, pharmacy, or physical education students. Higher academic grades generally had better CVD knowledge compared to first-year students (12.6 +/- 3.7), (p = 0.04). Furthermore, high awareness was noted in several areas, including the role of blood pressure control (87.6%), physical activity (85.1%), obesity (85.6%), smoking (90%), and aging (89.6%) in CVD risk. Moderate awareness was observed for family history (75.1%), blood sugar control (70.1%), and myocardial oxygen supply (70.6%). However, low awareness was noted regarding the role of HDL cholesterol (45.8%) and the effect of fatty foods on cholesterol (23.9%). Although university students showed a generally good awareness of major cardiovascular risk factors, notable knowledge gaps persisted-especially regarding dietary fats and cholesterol types. These results highlight the importance of implementing targeted educational programs to improve cardiovascular health awareness among young adults in Egypt. FAU - Adel, Maha Ibrahim AU - Adel MI AD - Dental Public Health and Preventive Dentistry Department, Faculty of Dentistry, Pharos University in Alexandria, Alexandria, Egypt. FAU - Hall, Mohamed Ashraf AU - Hall MA AUID- ORCID: 0000-0001-9452-4232 AD - Alexandria Dental Research Center, Ministry of Health and Population, Alexandria, Egypt. FAU - Karawia, Inas AU - Karawia I AUID- ORCID: 0009-0000-8465-5685 AD - Dental Public Health and Preventive Dentistry Department, Faculty of Dentistry, Pharos University in Alexandria, Alexandria, Egypt. inas.karawia@pua.edu.eg. LA - eng PT - Journal Article DEP - 20260121 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - *Cardiovascular Diseases/epidemiology MH - Egypt/epidemiology MH - *Students/psychology MH - Universities MH - *Health Knowledge, Attitudes, Practice MH - Male MH - Young Adult MH - Cross-Sectional Studies MH - Surveys and Questionnaires MH - Risk Factors MH - Adult MH - Adolescent PMC - PMC12824341 OTO - NOTNLM OT - Awareness OT - Cardiovascular diseases OT - Egypt OT - Knowledge OT - Students COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This research was approved by the Research Ethics Committee at Pharos University under registration no. (UREAC-02-3-376). All methods were carried out in agreement with the Helsinki Declaration, before the beginning of the study. Written informed consent was obtained from all participants. They were informed that participation in the questionnaire was anonymous and completely voluntary. Secure data storage and restricted access to personal information to maintain confidentiality and ensure participant privacy. EDAT- 2026/01/21 01:48 MHDA- 2026/06/27 16:09 PMCR- 2026/01/21 CRDT- 2026/01/20 23:26 PHST- 2025/08/12 00:00 [received] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/06/27 16:09 [medline] PHST- 2026/01/21 01:48 [pubmed] PHST- 2026/01/20 23:26 [entrez] PHST- 2026/01/21 00:00 [pmc-release] AID - 10.1038/s41598-025-34137-6 [pii] AID - 34137 [pii] AID - 10.1038/s41598-025-34137-6 [doi] PST - epublish SO - Sci Rep. 2026 Jan 21;16(1):2637. doi: 10.1038/s41598-025-34137-6. PMID- 41559031 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260120 LR - 20260123 IS - 2056-5968 (Print) IS - 2056-5968 (Electronic) IS - 2056-5968 (Linking) VI - 12 IP - 1 DP - 2026 Jan 20 TI - IGF2BP3-dependent glutamine/BCAA metabolic rewiring rejuvenates aged human adipose-derived stem cells for enhanced tissue regeneration. PG - 5 LID - 10.1038/s41421-025-00860-7 [doi] LID - 5 AB - Aging impairs the regenerative capacity and differentiation potential of human adipose-derived stem cells (hASCs), but the mechanisms underlying their functional decline remain unclear. Through systematic functional assays and in vivo experiments, we first confirmed age-associated reductions in hASC self-renewal, lineage plasticity, and tissue repair efficacy. By integrating multiomics profiling and functional validation, we identified a metabolically active ACTA2(+)TAGLN(+) subpopulation that was enriched mainly in infant-derived hASCs (I-hASCs) and characterized by increased catabolism of branched-chain amino acids (BCAAs) and glutamine. Mechanistically, the RNA-binding protein IGF2BP3, which is predominantly expressed in the ACTA2(+)TAGLN(+) subpopulation, sustains hASC stemness by stabilizing BCAT1 and GLS mRNAs via METTL3-mediated m6A modification, thereby preserving redox homeostasis and mitochondrial energy production. Furthermore, age-related attenuation of the IGF2BP3-m6A-BCAT1/GLS axis contributed to metabolic reprogramming, driving senescence-associated functional collapse in elderly-derived hASCs (E-hASCs). Strikingly, rescue experiments demonstrated that genetic restoration of BCAT1/GLS or supplementation with BCAAs/glutamine significantly rejuvenated E-hASCs, restoring their proliferation, differentiation, and in vivo wound-healing capacities. These findings identify IGF2BP3 as a central regulator of hASC aging by linking m6A epitranscriptomic modifications to metabolic reprogramming and establish the IGF2BP3-m6A-BCAT1/GLS axis as a druggable node in aged hASCs. This study proposed two therapeutic strategies: nutrient supplementation to rescue metabolic deficits and m6A modulation to stabilize key mRNAs, providing a clinically feasible protocol to optimize elderly-derived hASCs for tissue regeneration. CI - (c) 2026. The Author(s). FAU - Li, Zichao AU - Li Z AD - Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. AD - Department of Plastic and Aesthetic Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China. AD - Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. FAU - Feng, Lin AU - Feng L AD - Department of Basic Medicine, Xi'an Medical University, Xi'an, Shaanxi, China. AD - Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, China. FAU - Wei, Xinxin AU - Wei X AD - Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, China. AD - Department of Stomatology, Weifang People's Hospital, Weifang, Shandong, China. FAU - Li, Huichen AU - Li H AD - Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, China. FAU - Zhu, Yifu AU - Zhu Y AD - Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. FAU - Wang, Hongtao AU - Wang H AD - Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. FAU - Liu, Jiaqi AU - Liu J AD - Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. FAU - Luo, Liang AU - Luo L AD - Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. FAU - Zheng, Zhao AU - Zheng Z AD - Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. FAU - Song, Baoqiang AU - Song B AD - Department of Plastic Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. songbq2012@163.com. FAU - Shen, Liangliang AU - Shen L AD - Department of Biochemistry and Molecular Biology, Fourth Military Medical University, Xi'an, Shaanxi, China. bioliangshen@163.com. AD - State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases, Fourth Military Medical University, Xi'an, Shaanxi, China. bioliangshen@163.com. FAU - Hu, Dahai AU - Hu D AD - Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi, China. hudhai@fmmu.edu.cn. LA - eng GR - 81971835/National Natural Science Foundation of China (National Science Foundation of China)/ GR - 82372524/National Natural Science Foundation of China (National Science Foundation of China)/ GR - 82073053/National Natural Science Foundation of China (National Science Foundation of China)/ PT - Journal Article DEP - 20260120 PL - England TA - Cell Discov JT - Cell discovery JID - 101661034 PMC - PMC12819398 COIS- Ethical approval: This study was approved by the ethics committee of the Fourth Military Medical University under reference number KY20202103-F-1. The study was conducted in accordance with the principles expressed in the Declaration of Helsinki. Furthermore, informed consent was obtained from all participants prior to their involvement in the study. For participants under the age of 16, informed consent was provided by a legal guardian. Conflict of interest: The authors declare no competing interests. EDAT- 2026/01/21 01:48 MHDA- 2026/01/21 01:49 PMCR- 2026/01/20 CRDT- 2026/01/20 23:13 PHST- 2025/03/20 00:00 [received] PHST- 2025/11/13 00:00 [accepted] PHST- 2026/01/21 01:49 [medline] PHST- 2026/01/21 01:48 [pubmed] PHST- 2026/01/20 23:13 [entrez] PHST- 2026/01/20 00:00 [pmc-release] AID - 10.1038/s41421-025-00860-7 [pii] AID - 860 [pii] AID - 10.1038/s41421-025-00860-7 [doi] PST - epublish SO - Cell Discov. 2026 Jan 20;12(1):5. doi: 10.1038/s41421-025-00860-7. PMID- 41558877 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260813 IS - 2352-7226 (Electronic) IS - 2352-7218 (Print) IS - 2352-7218 (Linking) VI - 12 IP - 2 DP - 2026 Apr TI - Effects of a single session intervention on actigraphy-measured sleep for adolescents with insufficient and irregular sleep: A randomized controlled trial. PG - 333-339 LID - S2352-7218(25)00280-3 [pii] LID - 10.1016/j.sleh.2025.12.008 [doi] AB - INTRODUCTION: We previously developed a brief, behavioral intervention (Sleep Promotion Program, SPP) that demonstrated feasibility, acceptability, and increased self-reported sleep. Here, we tested the effects of SPP on the trial's secondary outcomes: sleep duration, regularity, and timing as measured by actigraphy and conducted a secondary analysis of SPP's effects on rest-activity rhythms. METHODS: Forty participants (ages 13-15) with insufficient and irregular sleep randomized to SPP-continuation (n = 22), or to sleep monitoring-SPP (n = 18), had analyzable actigraphy data. SPP included sleep psychoeducation and one individual clinician session. Participants wore an actigraph for 1-2 weeks during baseline, Period 1, and Period 2. We hypothesized SPP would lead to longer and more regular sleep from baseline to Period 1 compared to sleep monitoring that would be sustained at Period 2. We used multilevel models with a treatment by time interaction to test whether SPP improved sleep relative to sleep monitoring. We also compared sleep changes from Period 1 to Period 2 among participants randomized to SPP-continuation. RESULTS: Participants receiving SPP decreased the difference in weekend-weekday sleep onset by 54-minute (beta = 1.1; p = .03) from baseline to Period 1 (i.e., increased regularity). Increased regularity was maintained at Period 2. Total sleep time did not change significantly. CONCLUSION: SPP regularized weekend-weekday sleep onset timing in adolescents with insufficient and irregular sleep but did not change actigraphic sleep duration, which differed from increases in self-reported sleep duration previously reported. Regularizing sleep may be an attainable first step to improving adolescent sleep. Future work is needed to test whether sleep regularity predicts adolescent health outcomes. CLINICAL TRIALS: Targeted Intervention for Insufficient Sleep among Typically-Developing Adolescents (TAPAS); https://clinicaltrials.gov/ct2/show/NCT04163003; NCT04163003. CI - Copyright (c) 2026 National Sleep Foundation. Published by Elsevier Inc. All rights reserved. FAU - Wescott, Delainey L AU - Wescott DL AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. FAU - Goldstein, Tina R AU - Goldstein TR AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. FAU - Wallace, Meredith L AU - Wallace ML AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Department of Statistics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. FAU - Miller, Elizabeth AU - Miller E AD - Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Division of Adolescent and Young Adult Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. FAU - Buysse, Daniel J AU - Buysse DJ AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. FAU - Harvey, Allison AU - Harvey A AD - Department of Psychology, University of California Berkeley, Berkeley, California, USA. FAU - Suffoletto, Brian AU - Suffoletto B AD - Department of Emergency Medicine, Stanford University, Stanford, California, USA. FAU - Rofey, Dana L AU - Rofey DL AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Clinicial and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. FAU - Levenson, Jessica C AU - Levenson JC AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA; Clinicial and Translational Science Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. Electronic address: levensonjc@upmc.edu. LA - eng SI - ClinicalTrials.gov/NCT04163003 GR - K23 HD087433/HD/NICHD NIH HHS/United States GR - T32 HL082610/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial DEP - 20260119 PL - United States TA - Sleep Health JT - Sleep health JID - 101656808 SB - IM MH - Humans MH - *Actigraphy MH - Adolescent MH - Female MH - Sleep Duration MH - Male MH - *Sleep MH - *Health Promotion/methods MH - *Sleep Deprivation/therapy MH - *Behavior Therapy/methods PMC - PMC12834487 MID - NIHMS2131749 OTO - NOTNLM OT - Actigraphy OT - Adolescents OT - Behavioral sleep interventions OT - Single-session interventions OT - Sleep regularity EDAT- 2026/01/21 01:48 MHDA- 2026/03/30 00:29 PMCR- 2027/01/19 CRDT- 2026/01/20 21:51 PHST- 2025/05/19 00:00 [received] PHST- 2025/12/04 00:00 [revised] PHST- 2025/12/16 00:00 [accepted] PHST- 2026/03/30 00:29 [medline] PHST- 2026/01/21 01:48 [pubmed] PHST- 2026/01/20 21:51 [entrez] PHST- 2027/01/19 00:00 [pmc-release] AID - S2352-7218(25)00280-3 [pii] AID - 10.1016/j.sleh.2025.12.008 [doi] PST - ppublish SO - Sleep Health. 2026 Apr;12(2):333-339. doi: 10.1016/j.sleh.2025.12.008. Epub 2026 Jan 19. PMID- 41558063 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260730 IS - 1532-4036 (Electronic) IS - 0964-3397 (Linking) VI - 93 DP - 2026 Apr TI - Early enteral nutritional support and clinical outcomes in critically ill children: A scoping review. PG - 104336 LID - S0964-3397(26)00004-2 [pii] LID - 10.1016/j.iccn.2026.104336 [doi] AB - BACKGROUND AND AIMS: Pediatric malnutrition, is defined as an imbalance between nutrient intake and requirements leading to cumulative energy, protein, or micronutrient deficits, is highly prevalent among critically ill children and negatively affects growth and recovery. Early enteral nutrition (EEN) is increasingly recognized as a key strategy to prevent or address malnutrition in pediatric intensive care units (PICUs). Although emerging evidence suggests that EEN improves clinical outcomes, uncertainty persists regarding its feasibility and impact in this population. This scoping review aimed to map existing evidence on the use of EEN in critically ill children, evaluate its effects on key clinical outcomes including mechanical ventilation duration, length of stay, and infection risk; and identify barriers and facilitators to its implementation in pediatric intensive care settings. METHODS: A scoping review was conducted following Joanna Briggs Institute methodology and PRISMA-ScR guidelines. Searches were performed in PubMed, Embase, Scopus, CINAHL, and the Cochrane Library. Studies were eligible if they involved children aged 1 month to 18 years and initiated enteral nutrition within 48 h of PICU admission. Keywords included child, critical illness, enteral nutrition, intensive care units, and pediatrics. Studies in English or Italian were included without date restrictions. RESULTS: Sixteen thousand seven hundred ninety-nine records were identified; 15,556 were screened after duplicates were removed, and 14 studies met inclusion criteria (USA n = 6; Asia n = 4; Africa n = 3; Europe n = 1). Most were cohort studies, with one randomized trial. EEN was consistently associated with shorter mechanical ventilation duration (5.86 +/- 3.63 vs 11.96 +/- 9.17 days, p = 0.002), reduced PICU and hospital length of stay (4 vs 11.5 days, p < 0.001), and lower infection rates (16.7 % vs 41.1 %, p = 0.001). Barriers to EEN included hemodynamic instability, gastrointestinal intolerance, and procedural interruptions, while facilitators included multidisciplinary teamwork, nurse-led feeding protocols, and standardized nutritional guidelines. CONCLUSION: EEN initiated within 24-48 h was generally associated with favorable clinical outcomes; however, evidence on feasibility and safety remains limited and heterogeneous. Strengthening nursing autonomy and implementing standardized feeding pathways may enhance timely nutrition delivery and support recovery in pediatric intensive care. IMPLICATIONS FOR CLINICAL PRACTICE: Pediatric intensive care nurses play a pivotal role in initiating and monitoring EEN. Empowering nurses through evidence-based feeding protocols and multidisciplinary education can promote timely nutrition delivery and improve recovery in critically ill children. CI - Copyright (c) 2026 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Maffeo, Marina AU - Maffeo M AD - Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy. Electronic address: marina.maffeo@students.uniroma2.eu. FAU - Caggianelli, Gabriele AU - Caggianelli G AD - Department of Healthcare Professions, Azienda Ospedaliera Complesso Ospedaliero San Giovanni Addolorata, Rome, Italy; Italian Evidence-based Practice Nursing Scholarship, JBI Centre of Excellence, Rome, Italy. Electronic address: caggianelligabriele@gmail.com. FAU - Buccione, Emanuele AU - Buccione E AD - Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy. Electronic address: emanuele.buccione@students.uniroma2.eu. FAU - Vanzi, Valentina AU - Vanzi V AD - Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy; Italian Evidence-based Practice Nursing Scholarship, JBI Centre of Excellence, Rome, Italy. Electronic address: valentina.vanzi@hotmail.it. FAU - Ciofi, Daniele AU - Ciofi D AD - Department of Healthcare Professions, Meyer Children's Hospital IRCCS, Florence, Italy. Electronic address: daniele.ciofi@meyer.it. FAU - Gregorini, Mirco AU - Gregorini M AD - Department of Healthcare Professions, Meyer Children's Hospital IRCCS, Florence, Italy. Electronic address: mirco.gregorini@meyer.it. FAU - Zega, Maurizio AU - Zega M AD - Italian Evidence-based Practice Nursing Scholarship, JBI Centre of Excellence, Rome, Italy; Order of Nursing Professions of Rome, Rome, Italy. Electronic address: maurizio.zega@fnopi.it. FAU - Fiorini, Jacopo AU - Fiorini J AD - Italian Evidence-based Practice Nursing Scholarship, JBI Centre of Excellence, Rome, Italy; Nursing Department, University Hospital of Rome Tor Vergata, Rome, Italy. Electronic address: jacopo.fiorini@ptvonline.it. LA - eng PT - Journal Article PT - Scoping Review DEP - 20260119 PL - Netherlands TA - Intensive Crit Care Nurs JT - Intensive & critical care nursing JID - 9211274 SB - IM MH - Humans MH - *Critical Illness/therapy/nursing MH - *Enteral Nutrition/methods/standards MH - Child MH - Child, Preschool MH - Infant MH - Intensive Care Units, Pediatric/organization & administration MH - Male MH - Female MH - Length of Stay/statistics & numerical data MH - Treatment Outcome OTO - NOTNLM OT - Child OT - Critical illness OT - Enteral nutrition OT - Intensive care unit OT - Pediatrics COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/20 19:20 MHDA- 2026/02/23 01:34 CRDT- 2026/01/20 17:59 PHST- 2025/08/01 00:00 [received] PHST- 2025/12/14 00:00 [revised] PHST- 2026/01/04 00:00 [accepted] PHST- 2026/02/23 01:34 [medline] PHST- 2026/01/20 19:20 [pubmed] PHST- 2026/01/20 17:59 [entrez] AID - S0964-3397(26)00004-2 [pii] AID - 10.1016/j.iccn.2026.104336 [doi] PST - ppublish SO - Intensive Crit Care Nurs. 2026 Apr;93:104336. doi: 10.1016/j.iccn.2026.104336. Epub 2026 Jan 19. PMID- 41556835 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260903 IS - 1522-1539 (Electronic) IS - 0363-6135 (Print) IS - 0363-6135 (Linking) VI - 330 IP - 3 DP - 2026 Mar 1 TI - Single-beat method echocardiographic comparison of ventricular-arterial coupling in adults with and without Down syndrome. PG - H664-H670 LID - 10.1152/ajpheart.01002.2025 [doi] AB - Adults with Down syndrome (Ds) demonstrate unique cardiovascular features, including smaller left ventricular volumes and lower blood pressure. Ventricular-arterial coupling (VAC), a key measure of cardiovascular efficiency, has not been previously studied in this adult population. Understanding VAC in adults with Ds may reveal compensatory mechanisms that maintain cardiac output despite distinct cardiovascular characteristics. This study used echocardiographic parameters to compare the VAC ratio of adults with and without Ds. Baseline echocardiographic data were collected from 28 adults with Ds and 18 adults without Ds (aged 18-35 yr), all of whom had low physical activity levels. The VAC ratio was calculated using the single-beat method. Adults with Ds had lower VAC ratios and diastolic blood pressure, faster preejection times, shorter normalized systolic durations, and a higher ejection fraction than adults without Ds. Adults with Ds exhibit distinct cardiovascular adaptations, including a lower VAC ratio and a shorter systolic duration, suggesting increased cardiac workload. Higher ejection fraction and faster preejection period indicate potential compensatory mechanisms to maintain cardiac output, whereas lower diastolic blood pressure may reduce coronary perfusion and preload. These findings demonstrate differences in cardiac function and timing in adults with Ds in this study.NEW & NOTEWORTHY This study reveals, for the first time, that adults with Down syndrome exhibit significantly lower ventricular-arterial coupling ratios, reflecting distinct cardiac timing and functional adaptations. These findings could indicate a compensatory mechanism to maintain cardiac output despite reduced diastolic pressure and smaller cardiac chambers, providing novel insight into the integrated cardiovascular physiology of adults with Down syndrome and its potential implications for exercise tolerance and long-term cardiovascular health. CI - Copyright (c) 2026 The Authors. FAU - Matthews, Alice AU - Matthews A AUID- ORCID: 0000-0002-2875-5224 AD - Department of Physical Therapy, University of Nevada, Las Vegas, Nevada, United States. FAU - Fernhall, Bo AU - Fernhall B AUID- ORCID: 0000-0001-9393-3018 AD - Donna M. and Robert J. Manning College of Nursing & Health Sciences, UMass Boston, Boston, Massachusetts, United States. FAU - Hilgenkamp, Thessa AU - Hilgenkamp T AUID- ORCID: 0000-0001-9882-163X AD - Department of Physical Therapy, University of Nevada, Las Vegas, Nevada, United States. LA - eng GR - R00 HD092606/HD/NICHD NIH HHS/United States GR - R00HD092606/HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)/ PT - Comparative Study PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260120 PL - United States TA - Am J Physiol Heart Circ Physiol JT - American journal of physiology. Heart and circulatory physiology JID - 100901228 SB - IM MH - Humans MH - *Down Syndrome/physiopathology/diagnostic imaging MH - Adult MH - Young Adult MH - Male MH - Female MH - Adolescent MH - *Ventricular Function, Left MH - Stroke Volume MH - Blood Pressure MH - Case-Control Studies MH - Cardiac Output MH - *Echocardiography MH - Predictive Value of Tests MH - *Heart Ventricles/diagnostic imaging/physiopathology PMC - PMC12947206 MID - NIHMS2143524 OTO - NOTNLM OT - Down syndrome OT - cardiac ultrasound OT - echocardiography OT - ventricular-arterial coupling COIS- DISCLOSURES No conflict of interest for any of the authors. EDAT- 2026/01/20 14:03 MHDA- 2026/02/10 19:00 PMCR- 2026/02/27 CRDT- 2026/01/20 10:13 PHST- 2026/02/10 19:00 [medline] PHST- 2026/01/20 14:03 [pubmed] PHST- 2026/01/20 10:13 [entrez] PHST- 2026/02/27 00:00 [pmc-release] AID - 10.1152/ajpheart.01002.2025 [doi] PST - ppublish SO - Am J Physiol Heart Circ Physiol. 2026 Mar 1;330(3):H664-H670. doi: 10.1152/ajpheart.01002.2025. Epub 2026 Jan 20. PMID- 41556732 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260630 IS - 1827-1928 (Electronic) IS - 0022-4707 (Linking) VI - 66 IP - 3 DP - 2026 Mar TI - Further evidence on the psychometric properties and convergent validity of the expanded exercise addiction inventory (EAI-3) in recreational exercisers. PG - 464-474 LID - 10.23736/S0022-4707.25.17274-5 [doi] AB - BACKGROUND: Exercise addiction (EA) is a maladaptive pattern of excessive exercise despite negative physical, psychological, and social consequences. The Expanded Exercise Addiction Inventory (EAI-3) was developed to improve the assessment of EA. This study validates the Hebrew version of the EAI-3 in Israel, where physical fitness is closely tied to national identity and military culture. METHODS: A sample of 367 recreational exercisers (140 men, 227 women; aged 18-45) completed the Hebrew EAI-3, the Exercise Dependence Scale-Revised (EDS-R), and the Eating Attitudes Test (EAT-26). Confirmatory factor analysis (CFA) and measurement invariance testing were conducted. RESULTS: CFA supported a two-factor structure (Health Relevance and Addiction Tendency). A 7-item version demonstrated superior psychometric properties compared to the original 8-item scale. Internal consistency was moderate (alpha=0.61), but McDonald's omega (omega=0.68) indicated better reliability. The EAI-3 showed strong convergent validity with the EDS-R (r=0.45) and concurrent validity with the EAT-26 (r=0.24). The 7-item version achieved scalar invariance across gender, allowing for meaningful comparisons. CONCLUSIONS: The Hebrew EAI-3 is a valid tool for assessing risk of exercise addiction in Israeli exercisers. The 7-item version is recommended for clinical and research applications, particularly for gender-based analyses. FAU - Lev Arey, Dalit AU - Lev Arey D AD - Department of Psychology, Academic College of Tel Aviv-Yaffo, Tel Aviv, Israel - dalitlevarey@gmail.com. FAU - Levental, Orr AU - Levental O AD - Department of Physical Education, Tel Hai Academic College, Upper Galilee, Israel. FAU - Yaffe, Yosi AU - Yaffe Y AD - Department of Physical Education, Tel Hai Academic College, Upper Galilee, Israel. LA - eng PT - Journal Article PT - Validation Study DEP - 20260120 PL - Italy TA - J Sports Med Phys Fitness JT - The Journal of sports medicine and physical fitness JID - 0376337 SB - IM MH - Humans MH - Psychometrics MH - *Behavior, Addictive/diagnosis/psychology MH - Male MH - Female MH - Reproducibility of Results MH - Adult MH - Israel MH - Adolescent MH - Young Adult MH - *Exercise/psychology MH - Middle Aged MH - Surveys and Questionnaires MH - Factor Analysis, Statistical EDAT- 2026/01/20 14:03 MHDA- 2026/03/06 08:59 CRDT- 2026/01/20 09:25 PHST- 2026/03/06 08:59 [medline] PHST- 2026/01/20 14:03 [pubmed] PHST- 2026/01/20 09:25 [entrez] AID - S0022-4707.25.17274-5 [pii] AID - 10.23736/S0022-4707.25.17274-5 [doi] PST - ppublish SO - J Sports Med Phys Fitness. 2026 Mar;66(3):464-474. doi: 10.23736/S0022-4707.25.17274-5. Epub 2026 Jan 20. PMID- 41556486 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260630 IS - 2326-3660 (Electronic) IS - 0091-3847 (Linking) VI - 54 IP - 3 DP - 2026 Jun TI - Sex-based differences in pediatric lateral ankle avulsion fractures: males are more likely to sustain avulsion fractures. PG - 207-213 LID - 10.1080/00913847.2026.2620362 [doi] AB - OBJECTIVE: To assess sex-based differences in the frequency and characteristics of pediatric lateral ankle avulsion fractures. METHODS: This prospective observational cohort study (Level II) was conducted at a tertiary sports medicine clinic between July 2022 and March 2025. This study included a total of 132 patients with 133 injuries aged 5-12 years presenting within 30 days of a first-time lateral ankle injury (67.4% female and 32.6% male). Injuries were categorized as avulsion or non-avulsion using ultrasound as the reference standard. Demographics, injury type and mechanism, sport type, and validated patient-reported measures were analyzed by sex using chi-squared and Mann-Whitney U tests. RESULTS: Males were found to be significantly more likely to sustain lateral ankle avulsion fractures than their female counterparts (50.0% vs. 24.1%, p < 0.01). There were no statistically significant differences between the avulsion and non-avulsion groups for age, race, ethnicity, BMI, or days to presentation. Sport during injury did vary by sex (p = 0.02), but the cause of injury did not. Pain, mobility, anxiety, and Pedi-FABS scores did not vary between sexes at presentation, regardless of their avulsion status. CONCLUSIONS: Our study demonstrated that males with lateral ankle injuries were more likely to sustain avulsion fractures than females in this pediatric population. Despite these differences in injury type, both sexes reported similar levels of function, anxiety, pain, and activity at initial presentation. Understanding early sex-based differences in lateral ankle fracture patterns may inform diagnostic evaluation and management in pediatric patients. FAU - Reese, Lauren T AU - Reese LT AD - School of Medicine, University of Texas Southwestern, Dallas, TX, USA. FAU - Schultz, Cassidy M AU - Schultz CM AD - Department of Sports Medicine, Scottish Rite for Children, Frisco, TX, USA. FAU - Van Pelt, Robert L AU - Van Pelt RL AD - Department of Sports Medicine, Scottish Rite for Children, Frisco, TX, USA. FAU - Lampe, Katherine AU - Lampe K AD - Department of Sports Medicine, Scottish Rite for Children, Frisco, TX, USA. FAU - Chung, Jane S AU - Chung JS AD - School of Medicine, University of Texas Southwestern, Dallas, TX, USA. AD - Department of Sports Medicine, Scottish Rite for Children, Frisco, TX, USA. FAU - Miller, Shane M AU - Miller SM AD - School of Medicine, University of Texas Southwestern, Dallas, TX, USA. AD - Department of Sports Medicine, Scottish Rite for Children, Frisco, TX, USA. FAU - Wyatt, Charles W AU - Wyatt CW AD - School of Medicine, University of Texas Southwestern, Dallas, TX, USA. AD - Department of Sports Medicine, Scottish Rite for Children, Frisco, TX, USA. FAU - Ellis, Henry B AU - Ellis HB AD - School of Medicine, University of Texas Southwestern, Dallas, TX, USA. AD - Department of Sports Medicine, Scottish Rite for Children, Frisco, TX, USA. FAU - Wilson, Philip L AU - Wilson PL AD - School of Medicine, University of Texas Southwestern, Dallas, TX, USA. AD - Department of Sports Medicine, Scottish Rite for Children, Frisco, TX, USA. FAU - Jones, Jacob C AU - Jones JC AD - School of Medicine, University of Texas Southwestern, Dallas, TX, USA. AD - Department of Sports Medicine, Scottish Rite for Children, Frisco, TX, USA. LA - eng PT - Journal Article PT - Observational Study DEP - 20260127 PL - England TA - Phys Sportsmed JT - The Physician and sportsmedicine JID - 0427461 SB - IM MH - Humans MH - Male MH - Child MH - Prospective Studies MH - Child, Preschool MH - Female MH - *Fractures, Avulsion/epidemiology/diagnostic imaging MH - Sex Factors MH - *Ankle Fractures/epidemiology/diagnostic imaging MH - *Ankle Injuries/epidemiology MH - Ultrasonography OTO - NOTNLM OT - Diagnostic imaging OT - injury epidemiology OT - ligamentous injuries OT - sports medicine OT - ultrasonography EDAT- 2026/01/20 14:03 MHDA- 2026/06/01 12:38 CRDT- 2026/01/20 07:43 PHST- 2026/06/01 12:38 [medline] PHST- 2026/01/20 14:03 [pubmed] PHST- 2026/01/20 07:43 [entrez] AID - 10.1080/00913847.2026.2620362 [doi] PST - ppublish SO - Phys Sportsmed. 2026 Jun;54(3):207-213. doi: 10.1080/00913847.2026.2620362. Epub 2026 Jan 27. PMID- 41556285 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20261018 IS - 1362-301X (Electronic) IS - 0269-9052 (Print) IS - 0269-9052 (Linking) VI - 40 IP - 5 DP - 2026 Mar TI - miR-26b-5p responds to aerobic exercise intervention for concussion recovery in adolescent athletes: a pilot trial. PG - 357-364 LID - 10.1080/02699052.2026.2617973 [doi] AB - BACKGROUND: Guidelines for sport-related concussion (SRC) management recommend aerobic exercise treatment. Salivary microRNAs (miRNAs) associate with exercise and concussion; therefore, we investigated their expression in adolescents with SRC during prescribed exercise. METHODS: Before and after intervention, athletes with SRC (n = 32, 15.78 +/- 1.5 y/o, 66% male, 5.26 +/- 3.56 days from injury) and controls (n = 28, 15.96 +/- 1.7 y/o, 68% male) provided saliva samples and completed clinical exams. High (5 days/week, 30 min) or low (3 days/week, 20 min) volumes of aerobic exercise were assigned. RT-qPCRs were performed to assess 13 pre-selected miRNAs. RESULTS: miRNAs 1246, 944, 151a-3p, and 26b-5p were reduced (p = 0.0002, 0.0024, 0.0015, 0.0002, CI mean difference: [-4.55, -1.54] [-4.58, -1.08] [-4.77, -1.24] [-5.64, -1.92], respectively) compared to controls. The expression of 182-5p, 532-3p, and 26b-5p increased with exercise volume in concussed participants (p = 0.0035, 0.0035, 0.0020, CI for exercise coefficient: [0.000100, 0.000396] [0.000060, 0.000237] [0.000107, 0.000373], respectively), but not in controls. CONCLUSION: miRNAs 1246, 944, and 151a-3p may be concussion biomarkers unaffected by aerobic exercise. miR-26b-5p, associated with concussion and exercise volume, may be a useful biomarker to monitor adherence to exercise prescriptions for SRC recovery. FAU - Chizuk, Haley AU - Chizuk H AD - UBMD Department of Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Miecznikowski, Jeffrey C AU - Miecznikowski JC AD - Department of Biostatistics, School of Public Health and Health Professions, State University of New York at Buffalo, Buffalo, New York. FAU - Rawlings, Alex AU - Rawlings A AD - UBMD Department of Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Sayeed, Jaffer AU - Sayeed J AD - UBMD Department of Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Haider, Mohammad Nadir AU - Haider MN AD - UBMD Department of Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Leddy, John AU - Leddy J AD - UBMD Department of Orthopaedics and Sports Medicine, Jacobs School of Medicine and Biomedical Sciences, State University of New York at Buffalo, Buffalo, New York. FAU - Arany, Praveen AU - Arany P AD - Department of Oral Biology, School of Dental Medicine, State University of New York at Buffalo, Buffalo, New York. LA - eng GR - UL1 TR001412/TR/NCATS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260119 PL - England TA - Brain Inj JT - Brain injury JID - 8710358 RN - 0 (MicroRNAs) RN - 0 (MIRN26 microRNA, human) SB - IM MH - Humans MH - Adolescent MH - Pilot Projects MH - Male MH - *MicroRNAs/metabolism MH - *Brain Concussion/metabolism/rehabilitation MH - Female MH - *Exercise/physiology MH - *Athletic Injuries/metabolism/rehabilitation MH - *Exercise Therapy/methods MH - Saliva/metabolism MH - Athletes MH - *Recovery of Function/physiology PMC - PMC12890018 MID - NIHMS2144009 OAB - This study was pre-registered at Clinicaltrials.gov (NCT05379930). The analysis plan was not formally pre-registered. Power analysis was done using a simulation model and was calculated with pilot miRNA data using 1000 simulations at a p-value of 0.05. This simulation determined that we needed to recruit and retain 30 participants in our experimental group to reach a power of 80%, which was achieved. All participants are accounted for in our CONSORT Diagram in Supplementary File 3. All participants who were randomized provided saliva samples, and all saliva samples were analyzed. No deaths occurred during the study. Incomplete examinations occurred only because of participants who were lost to follow-up (Supplementary File 3). Participants were not randomized and were assigned to groups based on stratification by sex and sequential presentation. Participant blinding was not possible because of the nature of the therapeutic intervention, but participants were blinded to the study hypothesis. Investigator blinding was not fully possible because of the nature of the therapeutic intervention. The treating physician was blinded to intervention assignment.Human participants were blinded to the results of the fluid biomarker measurements. Handling of biofluid samples was performed by team members who were aware of the relevant characteristics of the participants. Fluid biomarker measurements were performed by investigators who were aware of the relevant characteristics of the participants. Fluid biomarker quality control decisions and analyses were performed by investigators who were aware of the relevant characteristics of the participants. Samples were acquired between March 2022 and February 2023. Samples were acquired between 9:00 AM and 3:00 PM. All samples were analyzed at the same time in a single batch. No unexpected events occurred in sample handling and analysis during the study. The number of technical replicates was 3 per sample. Technical replicate results were combined by averaging. No future use of these biofluid samples is possible because of insufficient remaining quantities. All equipment and analytical reagents used to perform measurements on the fluid biomarkers are widely available commercially. The key inclusion criteria2 are established standards in the field. The statistical tests in the linear models were based on independence of observations, correct model selection, and asymptotic normality assumptions for maximum likelihood random variables. Chi-squared tests for categorical variables assumed independence of observations, and two-sample t-tests for continuous variables assumed near normality in each condition.Statistical analysis was performed by Jeffrey C. Miecznikowski, PhD (Statistics). The family-wise error rate across miRNAs at level 0.05 was controlled by the Bonferroni method to correct for multiple comparisons. No replication or external validation studies have been performed or are planned/ongoing at this time to our knowledge. De-identified data from this study are not available in a public archive. De-identified data from this study will be made available (as allowable according to institutional IRB standards) by emailing the corresponding author as of May 20th, 2025. The analytic code used to conduct the analyses presented in this study is not available in a public repository. The authors agree to provide the full content of the manuscript on request by contacting the corresponding author. OABL- eng OTO - NOTNLM OT - Concussion OT - adolescent OT - athlete OT - biomarker OT - exercise OT - microRNA COIS- Disclosure statement No potential conflict of interest was reported by the author(s). Conflicts of interest The authors do not declare any relevant conflicts of interest. EDAT- 2026/01/20 14:03 MHDA- 2026/03/20 03:47 PMCR- 2026/02/11 CRDT- 2026/01/20 06:04 PHST- 2026/03/20 03:47 [medline] PHST- 2026/01/20 14:03 [pubmed] PHST- 2026/01/20 06:04 [entrez] PHST- 2026/02/11 00:00 [pmc-release] AID - 10.1080/02699052.2026.2617973 [doi] PST - ppublish SO - Brain Inj. 2026 Mar;40(5):357-364. doi: 10.1080/02699052.2026.2617973. Epub 2026 Jan 19. PMID- 41555649 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260630 IS - 1365-2214 (Electronic) IS - 0305-1862 (Print) IS - 0305-1862 (Linking) VI - 52 IP - 1 DP - 2026 Jan TI - Screen Time, Fatigue, Obesity and Physical Inactivity: Health Correlates of Problematic Smartphone Use in Adolescents. PG - e70237 LID - 10.1111/cch.70237 [doi] LID - e70237 AB - OBJECTIVE: This study aimed to determine the prevalence of problematic smartphone use (PSU) among Tunisian adolescents, examine variations by sex and age and investigate associations with physical activity, fatigue and obesity while assessing the potential protective role of sports participation. METHODS: A cross-sectional study of 960 adolescents (53% female), aged 14-16 years utilized validated Arabic instruments including the Smartphone Addiction Scale-Short Version (SAS-SV), International Physical Activity Questionnaire (IPAQ-SF) and Fatigue Assessment Scale (FAS). Anthropometric measurements followed WHO protocols, and objective screen time data were collected from device tracking features. Statistical analyses included Mann-Whitney U tests, chi-square tests, Spearman's correlations and logistic regression models with sex stratification, all adjusted for multiple comparisons using Benjamini-Hochberg correction. RESULTS: PSU prevalence was 15.7%, with significantly higher rates in males (p < 0.001) and during mid-adolescence (p < 0.001). Adolescents with PSU showed substantially higher screen time (435 vs. 155 min/day, p < 0.001), reduced vigorous physical activity (0 vs. 480 MET-min/week, p < 0.001), increased obesity (12.6% vs. 0.7%, p < 0.001) and more severe fatigue (50.3% vs. 5.8%, p < 0.001). Sports participation demonstrated protective effects against PSU (OR = 0.4-0.6), with significantly stronger effects in females (interaction p = 0.03). CONCLUSION: PSU represents a significant public health concern among Tunisian adolescents, with a prevalence of 15.7% that is higher in males and mid-adolescents. It is associated with excessive screen time, inactivity, elevated BMI and fatigue, whereas sports participation offers a protective effect, particularly among girls. CI - (c) 2026 The Author(s). Child: Care, Health and Development published by John Wiley & Sons Ltd. FAU - Yaakoubi, Mohamed AU - Yaakoubi M AUID- ORCID: 0009-0003-5187-236X AD - High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, at the National Observatory of Sport, Tunis, Tunisia. FAU - Ghorbel, Ahmed AU - Ghorbel A AUID- ORCID: 0009-0004-6890-9867 AD - High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, at the National Observatory of Sport, Tunis, Tunisia. FAU - Abdelkafi, Hiba AU - Abdelkafi H AUID- ORCID: 0000-0002-9869-456X AD - The High Institute of Applied Studies in Humanities of Mahdia, Department of Education Sciences, University of Monastir, Mahdia, Tunisia. FAU - Masmoudi, Liwa AU - Masmoudi L AUID- ORCID: 0000-0002-9628-1585 AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, at the National Observatory of Sport, Tunis, Tunisia. AD - High Institute of Sports and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. FAU - Gharbi, Adnene AU - Gharbi A AUID- ORCID: 0000-0001-9971-1993 AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, at the National Observatory of Sport, Tunis, Tunisia. AD - High Institute of Sports and Physical Education of Sfax, University of Sfax, Sfax, Tunisia. FAU - Trabelsi, Omar AU - Trabelsi O AUID- ORCID: 0009-0008-2568-3000 AD - High Institute of Sports and Physical Education of Kef, University of Jendouba, Kef, Tunisia. AD - Research Unit: Physical Activity, Sport and Health, UR18JS01, at the National Observatory of Sport, Tunis, Tunisia. AD - The High Institute of Applied Studies in Humanities of Mahdia, Department of Education Sciences, University of Monastir, Mahdia, Tunisia. LA - eng PT - Journal Article PL - England TA - Child Care Health Dev JT - Child: care, health and development JID - 7602632 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Screen Time MH - Cross-Sectional Studies MH - Male MH - *Sedentary Behavior MH - *Smartphone/statistics & numerical data MH - *Fatigue/epidemiology/psychology MH - *Exercise MH - Tunisia/epidemiology MH - Adolescent Behavior/psychology MH - Prevalence MH - *Behavior, Addictive/epidemiology MH - *Obesity/epidemiology MH - Sex Factors MH - *Internet Addiction Disorder/epidemiology PMC - PMC12816945 OTO - NOTNLM OT - adolescence OT - fatigue OT - gender differences OT - overweight OT - physical activity OT - sedentary behaviour OT - smartphone addiction COIS- The authors declare no potential conflicts of interest. EDAT- 2026/01/20 07:44 MHDA- 2026/01/20 07:45 PMCR- 2026/01/20 CRDT- 2026/01/20 01:42 PHST- 2025/12/24 00:00 [revised] PHST- 2025/08/22 00:00 [received] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/01/20 07:45 [medline] PHST- 2026/01/20 07:44 [pubmed] PHST- 2026/01/20 01:42 [entrez] PHST- 2026/01/20 00:00 [pmc-release] AID - CCH70237 [pii] AID - 10.1111/cch.70237 [doi] PST - ppublish SO - Child Care Health Dev. 2026 Jan;52(1):e70237. doi: 10.1111/cch.70237. PMID- 41555079 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260813 IS - 1433-9285 (Electronic) IS - 0933-7954 (Print) IS - 0933-7954 (Linking) VI - 61 IP - 5 DP - 2026 May TI - Reducing social disparities in child emotional and behavioral problems by hypothetical physical activity and screen time interventions. PG - 819-828 LID - 10.1007/s00127-025-03036-6 [doi] AB - PURPOSE: To estimate how social disparities in child psychiatric symptoms might change following hypothetical interventions targeting sports, outdoor play, and screen time at age 10. METHODS: We used data from 9,778 children of the Generation R Study, a prospective population-based cohort in Rotterdam, the Netherlands. Social inequality variables included sex, maternal education, and migration background. Primary caregivers filled out the validated Child Behavior Checklist to report on children's internalizing and externalizing symptoms at the age of 13. The hypothetical interventions (i.e., outdoor play, sports participation, and screen time) were parent-reported at age 10. We used sequential G-estimation to estimate the inequality with and without the hypothetical intervention. RESULTS: Children with migration backgrounds (46.3%) and low maternal education (53.3%) were associated with relatively more internalizing and externalizing symptoms than peers, with disparities of 0.125 and 0.177 standard deviations, respectively. Girls had more internalizing symptoms (0.106 SD), while boys had more externalizing symptoms (0.154 SD). Increasing sports participation reduced disparities in internalizing symptoms linked to maternal education (beta = -0.014; 95% CI: -0.024, -0.003), while outdoor play and screen time interventions showed limited effects. None of the hypothetical interventions led to a statistically significant reduction in social disparities in externalizing symptoms. CONCLUSIONS: This study underscores the persistence of sex, cultural, and socioeconomic disparities in youth mental health. While sports participation showed a potential effect in reducing disparities in internalizing symptoms, its impact on externalizing symptoms and other interventions was negligible. Future efforts should focus on identifying more effective strategies for addressing these disparities. CI - (c) 2026. The Author(s). FAU - Rodriguez-Ayllon, Maria AU - Rodriguez-Ayllon M AUID- ORCID: 0000-0002-8267-0440 AD - Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Center, Rotterdam, 3000 CA, The Netherlands. AD - Biomedical Research Institute of Malaga (IBIMA Platform Bionand), Malaga, Spain. AD - Prevention and Health Promotion Research Network (redIAPP) & Chronicity, Primary Care and Health Promotion Research Network, (RICAPPS), ISCIII, Madrid, Spain. FAU - Jansen, Pauline W AU - Jansen PW AUID- ORCID: 0000-0001-7747-5803 AD - Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Center, Rotterdam, 3000 CA, The Netherlands. p.w.jansen@erasmusmc.nl. AD - Department of Psychology, Education and Child Studies, Erasmus School of Social and Behavioural Sciences, Erasmus University, Rotterdam, The Netherlands. p.w.jansen@erasmusmc.nl. FAU - Labrecque, Jeremy A AU - Labrecque JA AUID- ORCID: 0000-0002-1028-2158 AD - Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. FAU - Enthoven, Clair A AU - Enthoven CA AUID- ORCID: 0000-0003-0812-8765 AD - Department of Child and Adolescent Psychiatry/Psychology, Erasmus MC University Medical Center, Rotterdam, 3000 CA, The Netherlands. AD - The Generation R Study Group, Erasmus University Medical Center, Rotterdam, The Netherlands. LA - eng GR - CD23/00096/Instituto de Salud Carlos III/ PT - Journal Article DEP - 20260119 PL - Germany TA - Soc Psychiatry Psychiatr Epidemiol JT - Social psychiatry and psychiatric epidemiology JID - 8804358 SB - IM MH - Humans MH - Female MH - Male MH - Netherlands/epidemiology MH - Child MH - *Screen Time MH - *Exercise/psychology MH - Prospective Studies MH - Socioeconomic Disparities in Health MH - *Child Behavior/psychology MH - Sports/psychology MH - Adolescent MH - *Child Behavior Disorders/epidemiology/prevention & control MH - Socioeconomic Factors PMC - PMC13156153 OTO - NOTNLM OT - Childhood OT - Exercise OT - Mental health OT - Social disparities OT - Sports OT - Youth COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/01/20 00:37 MHDA- 2026/05/08 12:38 PMCR- 2026/01/19 CRDT- 2026/01/19 23:31 PHST- 2025/07/10 00:00 [received] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/05/08 12:38 [medline] PHST- 2026/01/20 00:37 [pubmed] PHST- 2026/01/19 23:31 [entrez] PHST- 2026/01/19 00:00 [pmc-release] AID - 10.1007/s00127-025-03036-6 [pii] AID - 3036 [pii] AID - 10.1007/s00127-025-03036-6 [doi] PST - ppublish SO - Soc Psychiatry Psychiatr Epidemiol. 2026 May;61(5):819-828. doi: 10.1007/s00127-025-03036-6. Epub 2026 Jan 19. PMID- 41555069 OWN - NLM STAT- MEDLINE DCOM- 20260630 LR - 20260717 IS - 1476-5454 (Electronic) IS - 0950-222X (Print) IS - 0950-222X (Linking) VI - 40 IP - 5 DP - 2026 Apr TI - Optimised multivariable prediction model to predict treatment requirement in preterm infants with retinopathy of prematurity. PG - 617-623 LID - 10.1038/s41433-026-04245-2 [doi] AB - BACKGROUND: Retinopathy of prematurity (ROP) is a leading cause of blindness in preterm infants. However, frequent fundus examinations place burdens on neonates, families, and healthcare staff. We aimed to develop a model to identify low-risk infants and reduce the number of patients requiring screening. METHODS: We conducted a single-centre retrospective cohort study at the University of Tokyo Hospital (October 2019-December 2024), including infants with birth weight Objectives: Women with prepregnancy polycystic ovary syndrome (PCOS) may face higher risks during pregnancy, yet evidence on its link to severe maternal morbidity (SMM) is limited. This population-based study addresses these gaps. DESIGN: This was a population-based cohort study using linked administrative health data from Ontario, Canada. All hospital livebirths and stillbirths 2006-2021, in women aged 15-50 years were included. PARTICIPANTS/MATERIALS, SETTING, METHODS: PCOS was identified using a validated algorithm combining diagnostic codes for PCOS or hirsutism with irregular menses. Among 1,596,228 pregnancies, 110,910 (6.9%) had prior PCOS, diagnosed a median 11 years before delivery. RESULTS: Women with PCOS were older and more often obese. SMM occurred in 2.6 vs. 2.2 per 100 births among women with and without PCOS, respectively (adjusted relative risk 1.10, 95% CI: 1.06-1.15). LIMITATIONS: Limitations include potential residual confounding and misclassification inherent in administrative data. CONCLUSIONS: PCOS confers a modest but significant increase in SMM, underscoring the need for targeted risk assessment and preventive strategies. Awareness of this association may inform clinical risk assessment and management strategies to mitigate serious maternal complications.

. CI - (c) 2026 The Author(s). Published by S. Karger AG, Basel. FAU - Hincapie, Maria A AU - Hincapie MA AD - Department of Obstetrics and Gynecology, McGill University, McGill University Health Centre, Montreal, Quebec, Canada. FAU - Ray, Joel G AU - Ray JG AD - ICES, Toronto, Ontario, Canada. AD - Department of Medicine, University of Toronto, Toronto, Ontario, Canada. FAU - Shellenberger, Jonas AU - Shellenberger J AD - ICES, Toronto, Ontario, Canada. FAU - Velez, Maria P AU - Velez MP AD - Department of Obstetrics and Gynecology, McGill University, McGill University Health Centre, Montreal, Quebec, Canada, maria.p.velez@mcgill.ca. AD - ICES, Toronto, Ontario, Canada, maria.p.velez@mcgill.ca. AD - Research Institute McGill University Health Centre, Montreal, Quebec, Canada, maria.p.velez@mcgill.ca. LA - eng PT - Journal Article DEP - 20260119 PL - Switzerland TA - Gynecol Obstet Invest JT - Gynecologic and obstetric investigation JID - 7900587 SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/epidemiology/complications/diagnosis MH - Pregnancy MH - *Pregnancy Complications/epidemiology/etiology MH - Adult MH - Ontario/epidemiology MH - Adolescent MH - Young Adult MH - Cohort Studies MH - Risk Factors MH - Obesity/epidemiology PMC - PMC12912763 OTO - NOTNLM OT - Maternal outcomes OT - Polycystic ovary syndrome OT - Pregnancy complications OT - Severe maternal morbidity COIS- Maria P. Velez was a member of the journal's Editorial Board at the time of submission. The remaining authors have no conflicts of interest to declare. EDAT- 2026/01/19 18:33 MHDA- 2026/07/16 18:45 PMCR- 2026/01/19 CRDT- 2026/01/19 13:23 PHST- 2025/09/23 00:00 [received] PHST- 2026/01/07 00:00 [accepted] PHST- 2026/07/16 18:45 [medline] PHST- 2026/01/19 18:33 [pubmed] PHST- 2026/01/19 13:23 [entrez] PHST- 2026/01/19 00:00 [pmc-release] AID - 000550502 [pii] AID - 550502 [pii] AID - 10.1159/000550502 [doi] PST - ppublish SO - Gynecol Obstet Invest. 2026;91(4):480-483. doi: 10.1159/000550502. Epub 2026 Jan 19. PMID- 41553829 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1545-1569 (Electronic) IS - 1055-6656 (Print) IS - 1055-6656 (Linking) VI - 63 IP - 3 DP - 2026 Mar TI - Food Security Impacts Health of Children With Orofacial Clefts: An 8-Year Review of the Global Burden of Disease Study. PG - 487-496 LID - 10.1177/10556656251414227 [doi] AB - ObjectiveTo determine if increased food security (FS) reduces mortality, prevalence, and disability in patients with orofacial clefts (OFCs).DesignEcological study.SettingA total of 204 countries and territories in the Global Burden of Disease Study and FS data from 113 countries from the Global Food Security Index.Patients, ParticipantsDeidentified country-level data on patients with OFCs <4 years old from years 2012 to 2019.InterventionsNone.Main Outcome MeasureNumber of deaths from OFCs, prevalence of OFCs, and disability adjusted life years (DALYs) from OFCs per 100,000 people.ResultsOf 113 countries with data from 2012 to 2019, regression showed a 13.8% decreased rate of death (incidence rate ratio 0.862 [95% confidence interval (CI) 0.852, 0.871]) and 74.9% higher odds of nondeath (odds ratio 1.749 [95% CI 1.106, 2.786]) with a 1-point increase in FS score. A linear relationship was demonstrated between FS and prevalence of OFCs (beta -18.5 [95% CI -34.8, -2.3]) and DALYs from OFCs (beta -43.1 [95% CI -62.6, -23.5]) with a 1-point increase in FS score as well. The greatest reductions in mortality and DALYs were seen in children <1 year whereas reductions in prevalence were seen in children 2-4 years, attributed to decreases in late presentations.ConclusionOur study shows higher FS is associated with reduced deaths from OFCs, prevalence of OFCs, and DALYs from OFCs. We hope our study validates efforts by nutritional programs led by OFC teams and provides evidence for further support. FAU - Tiongco, Rafael Felix P AU - Tiongco RFP AD - Department of General Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA. RINGGOLD: 12258 FAU - Malek, Andrew J AU - Malek AJ AUID- ORCID: 0000-0001-8321-1978 AD - Division of Plastic and Reconstructive Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA. RINGGOLD: 12258 FAU - Ali, Ayman AU - Ali A AD - Department of General Surgery, Duke University, Durham, NC, USA. RINGGOLD: 3065 FAU - He, Hua AU - He H AD - Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, LA, USA. RINGGOLD: 25812 FAU - Yu, Jack C AU - Yu JC AD - Section of Plastic and Reconstructive Surgery, Medical College of Georgia, Augusta University, Augusta, GA, USA. FAU - Lavie, Jennifer L AU - Lavie JL AD - Division of Plastic and Reconstructive Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA. RINGGOLD: 12258 AD - Manning Family Children's Hospital, New Orleans, LA, USA. FAU - King, Brett J AU - King BJ AUID- ORCID: 0000-0001-7139-7891 AD - Division of Plastic and Reconstructive Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA. RINGGOLD: 12258 AD - Manning Family Children's Hospital, New Orleans, LA, USA. FAU - Masoumy, Mohamad AU - Masoumy M AD - Division of Plastic and Reconstructive Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA. RINGGOLD: 12258 AD - Manning Family Children's Hospital, New Orleans, LA, USA. LA - eng GR - P20 GM109036/GM/NIGMS NIH HHS/United States PT - Journal Article DEP - 20260119 PL - United States TA - Cleft Palate Craniofac J JT - The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association JID - 9102566 SB - IM MH - Humans MH - *Cleft Palate/mortality/epidemiology MH - *Cleft Lip/mortality/epidemiology MH - Global Burden of Disease MH - Child, Preschool MH - Prevalence MH - Infant MH - *Food Security MH - Global Health MH - Disability-Adjusted Life Years MH - Male MH - Female PMC - PMC13249470 MID - NIHMS2169920 OTO - NOTNLM OT - Global Burden of Disease OT - cleft lip OT - cleft palate OT - food security OT - orofacial cleft COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/01/19 18:33 MHDA- 2026/03/07 06:38 PMCR- 2026/06/09 CRDT- 2026/01/19 12:43 PHST- 2026/03/07 06:38 [medline] PHST- 2026/01/19 18:33 [pubmed] PHST- 2026/01/19 12:43 [entrez] PHST- 2026/06/09 00:00 [pmc-release] AID - 10.1177/10556656251414227 [doi] PST - ppublish SO - Cleft Palate Craniofac J. 2026 Mar;63(3):487-496. doi: 10.1177/10556656251414227. Epub 2026 Jan 19. PMID- 41551470 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 14 DP - 2026 TI - Application of the Ballroom Aerobic Test protocol for assessing performance in standard-style dancesport athletes. PG - e20556 LID - 10.7717/peerj.20556 [doi] LID - e20556 AB - BACKGROUND: Although the existing field-based tests to assess functional capacity in dancesport have been developed, most of them have been applied to ballet or contemporary dancesport athletes at the individual level, while little evidence is available for dancesport couples in standard dance disciplines. Therefore, the main purpose of this study was to examine the test-retest reliability and usefulness of the progressive Ballroom Aerobic Test (BAT) protocol for assessing aerobic performance. METHODS: Thirteen standard dancesport athletes (six pairs and one individual male participant; age: 20.1 +/- 3.8 years; height: 175.0 +/- 8.2 cm; weight: 64.3 +/- 9.7 kg; males; age: 19.9 +/- 3.7 years; height: 180.0 +/- 4.7 cm; weight: 70.2 +/- 8.7 kg; body mass index: 21.5 +/- 1.8 kg/m2 training experience: 8.6 +/- 5.1 years; females; age: 20.3 +/- 4.0 years; height: 168.5 +/- 6.5 cm; weight: 57.5 +/- 5.5 kg; body mass index: 20.2 +/- 1.3 kg/m(2); training experience: 8.5 +/- 3.4 years) took part in the study. All participants were members of certified dancesport clubs who competed at national and international levels. The BAT protocol consisted of five stages, each corresponding to one of five standard dancesport disciplines (English Waltz, Slow Foxtrot, Tango, Viennese Waltz, and Quickstep). A test-retest design, with one week between trials, was used to examine the reliability measures. Ventilatory and metabolic parameters were derived from MetaMax((R)) 3B, a reliable and valid portable gas analyzer. Reliability measures included Cohen D effect size (ES), intra-class correlation coefficient (ICC), coefficient of variation (CV), typical error (TE) and smallest worthwhile change (SWC). RESULTS: No significant differences were observed between test and retest sessions (P > 0.05). ESs ranged from trivial to small (0.00-0.47) with 'very good' to 'excellent' reliability (ICC = 0.80-0.99; CV = 1.63-4.85%). The usefulness of the BAT protocol was generally rated as 'ok' to 'good' for speed (TE = 2.76; SWC = 3.20; <), absolute VO(2) (TE = 0.14; SWC = 0.15; <), respiratory exchange ratio (RER; TE = 0.02; SWC = 0.02; =), tidal volume (VT = 0.06; SWC = 0.06; =), and dead space to tidal volume ratio (VD/VT; TE = 0.01; SWC = 0.01; =). CONCLUSION: Current findings suggest that the BAT protocol is a reliable and useful tool for assessing aerobic capacity in standard-style dancesport athletes. Moreover, the BAT protocol can accurately detect meaningful individual changes, particularly for speed (3.20 bpm), absolute VO(2) (0.15 L*min(-1)), and VE (4.87 L). These results may assist athletes and strength and conditioning coaches in monitoring and tracking 'real' time changes to optimize the training process. CI - (c)2026 Despot and Plavec. FAU - Despot, Tamara AU - Despot T AD - Faculty of Kinesiology, University Zagreb, Zagreb, Croatia. AD - Dance Studio 'Dancespot', Zagreb, Croatia. FAU - Plavec, Davor AU - Plavec D AD - Facility for Medical Care 'Prima Nova', Zagreb, Croatia. AD - Medical Faculty, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia. LA - eng PT - Journal Article DEP - 20260113 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 SB - IM MH - Humans MH - Male MH - Reproducibility of Results MH - *Exercise Test/methods MH - Female MH - Oxygen Consumption/physiology MH - Young Adult MH - *Dancing/physiology MH - *Athletes MH - *Athletic Performance/physiology MH - Adolescent MH - Adult PMC - PMC12810390 OTO - NOTNLM OT - Aesthetic sports OT - Cardiorespiratory fitness OT - Coefficient of variation OT - Effect size OT - Smallest worthwhile change OT - The BAT protocol OT - Typical error COIS- Davor Plavec is an Academic Editor for PeerJ. Tamara Despot is employed by Dance studio 'Dancespot' and Davor Plavec is employed by Facility for medical care 'Prima Nova'. EDAT- 2026/01/19 12:51 MHDA- 2026/01/19 12:52 PMCR- 2026/01/13 CRDT- 2026/01/19 06:18 PHST- 2025/07/29 00:00 [received] PHST- 2025/11/18 00:00 [accepted] PHST- 2026/01/19 12:52 [medline] PHST- 2026/01/19 12:51 [pubmed] PHST- 2026/01/19 06:18 [entrez] PHST- 2026/01/13 00:00 [pmc-release] AID - 20556 [pii] AID - 10.7717/peerj.20556 [doi] PST - epublish SO - PeerJ. 2026 Jan 13;14:e20556. doi: 10.7717/peerj.20556. eCollection 2026. PMID- 41550860 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260119 LR - 20260121 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - The role of intestinal gases in pediatric functional constipation: a narrative review of pathophysiology and emerging therapeutics. PG - 1694831 LID - 10.3389/fnut.2025.1694831 [doi] LID - 1694831 AB - Pediatric functional constipation (PFC) is a prevalent gastrointestinal disorder affecting approximately 18.2% of children worldwide, characterized by infrequent or painful bowel movements without organic cause, and significantly impairing quality of life, yet its management remains suboptimal. A central problem in its management is the high failure rate of conventional therapies; notably, treatments such as laxatives fail to achieve sustained relief in about 40% of pediatric patients, highlighting the critical need to explore novel pathophysiological mechanisms and therapeutic targets. Emerging evidence now highlights gut microbiota dysbiosis and the resulting imbalances in intestinal gases-particularly hydrogen (H(2)), methane (CH(4)), carbon dioxide (CO(2)), and hydrogen sulfide (H(2)S)-as key drivers of its pathophysiology. This review synthesizes current knowledge on how microbial gas metabolism influences gut motility in PFC: elevated CH(4), produced by methanogenic archaea such as Methanobrevibacter smithii, strongly correlates with delayed colonic transit and symptom severity, while H(2) enhances motility, and CO(2) and H(2)S exert dose-dependent effects on peristalsis and mucosal signaling. Recent diagnostic advances, including H(2)/CH(4) breath testing, electronic nose (E-nose) volatile organic compound profiling, and wireless motility capsules, enable non-invasive assessment of gas dynamics and transit, supporting precision phenotyping. Therapeutic strategies targeting gas-microbiota interactions-such as methane-lowering antibiotics (e.g., rifaximin), probiotics (e.g., Lactobacillus plantarum), low-fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAP) diets, and neuromodulation-show promise, but pediatric-specific thresholds, safety, and long-term outcomes remain underexplored. The principal novelty of this review lies in its integrative framework, combining gastroenterology, microbiology, and engineering perspectives to advance gas-targeted precision medicine in PFC. Finally, we identify critical research gaps -such as the lack of pediatric-specific diagnostic thresholds and long-term therapeutic validation-and emphasize the urgent need for longitudinal studies and multidisciplinary trials to translate these insights into meaningful clinical outcomes. CI - Copyright (c) 2026 Zhou and Tao. FAU - Zhou, Yuewen AU - Zhou Y AD - Department of Pediatrics, The First People's Hospital of Pingjiang, Yueyang, Hunan, China. FAU - Tao, Enfu AU - Tao E AD - Department of Neonatology and NICU, Wenling Maternal and Child Health Care Hospital, Wenling, Zhejiang, China. LA - eng PT - Journal Article PT - Review DEP - 20260102 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12808438 OTO - NOTNLM OT - breath testing OT - gut microbiota dysbiosis OT - hydrogen OT - intestinal gas OT - methane OT - pediatric functional constipation COIS- The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/19 12:51 MHDA- 2026/01/19 12:52 PMCR- 2026/01/02 CRDT- 2026/01/19 06:12 PHST- 2025/09/01 00:00 [received] PHST- 2025/10/29 00:00 [revised] PHST- 2025/12/08 00:00 [accepted] PHST- 2026/01/19 12:52 [medline] PHST- 2026/01/19 12:51 [pubmed] PHST- 2026/01/19 06:12 [entrez] PHST- 2026/01/02 00:00 [pmc-release] AID - 10.3389/fnut.2025.1694831 [doi] PST - epublish SO - Front Nutr. 2026 Jan 2;12:1694831. doi: 10.3389/fnut.2025.1694831. eCollection 2025. PMID- 41548412 OWN - NLM STAT- MEDLINE DCOM- 20260219 LR - 20260730 IS - 1476-5616 (Electronic) IS - 0033-3506 (Linking) VI - 252 DP - 2026 Mar TI - Effects of school-based physical activity interventions on cardiorespiratory fitness and body composition in children and adolescents: A systematic review and meta-analysis using the RE-AIM framework. PG - 106141 LID - S0033-3506(26)00008-9 [pii] LID - 10.1016/j.puhe.2026.106141 [doi] AB - OBJECTIVES: This systematic review and meta-analysis aimed to (1) assess the effects of school-based physical activity (PA) interventions on cardiorespiratory fitness (CRF) and body composition in children and adolescents, and (2) evaluate internal validity (i.e., Reach and Effectiveness) and external validity (i.e., Adoption, Implementation, and Maintenance) reported in the included studies using the RE-AIM framework. STUDY DESIGN: Systematic review and meta-analysis. METHODS: Five databases (PubMed, Embase, Web of Science, EBSCO, and Cochrane Library) were searched for studies published from January 1, 2000, to July 10, 2024. Eligible studies were randomized or non-randomized controlled trials involving healthy children and adolescents aged 5-17 years. Only studies that reported CRF or body composition with PA or exercise as the sole intervention were included. RESULTS: 43 studies with a total of 27,626 participants were included in the meta-analysis. School-based PA interventions had a significant positive effect on CRF (SMD = 0.28, 95 % CI = 0.19 to 0.38; I(2) = 75 %). However, no significant effect of school-based PA interventions on percentage of body fat (%BF) was observed (SMD = -0.05, 95 % CI = -0.10 to 0.00; I(2) = 28 %). The total proportion of RE-AIM framework reported was 48.1 %. Among the five dimensions, Effectiveness is the most frequently reported (72.7 %), followed by Reach (53.1 %), Adoption (52.3 %), Implementation (42.4 %), and Maintenance (4.7 %). CONCLUSIONS: School-based PA interventions significantly improve CRF in youth but do not significantly reduce %BF. Moreover, internal validity indicators were reported more often than external validity components in the included studies. CI - Copyright (c) 2026. Published by Elsevier Ltd. FAU - Wang, Huihui AU - Wang H AD - Key Laboratory of Sports and Physical Health Ministry of Education, Beijing Sport University, Beijing, China; School of Sport Science, Beijing Sport University, Beijing, China. FAU - Bai, Xiaotian AU - Bai X AD - Division of Sports Science and Physical Education, Tsinghua University, Beijing, China. FAU - Cheng, Xiangrong AU - Cheng X AD - Department of Physical Education, Qingdao University of Technology, Qingdao, China. FAU - Dong, Xiaosheng AU - Dong X AD - Department of Social Medicine and Health Management, School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China; NHC Key Lab of Health Economics and Policy Research (Shandong University), Jinan, China; Center for Health Management and Policy Research, Shandong University (Shandong Provincial Key New Think Tank), Jinan, China; Institute of Health and Elderly Care, Shandong University, Jinan, China. FAU - Hou, Xiao AU - Hou X AD - Department of Physical Education, Peking University, Beijing, China. Electronic address: houxiao0327@pku.edu.cn. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20260117 PL - Netherlands TA - Public Health JT - Public health JID - 0376507 SB - IM MH - Humans MH - *Cardiorespiratory Fitness/physiology MH - Child MH - Adolescent MH - *Body Composition/physiology MH - *Exercise/physiology MH - *Schools MH - *School Health Services OTO - NOTNLM OT - Body composition OT - Cardiorespiratory fitness OT - Physical activity OT - RE-AIM OT - School OT - Student EDAT- 2026/01/19 01:03 MHDA- 2026/02/20 00:32 CRDT- 2026/01/18 18:05 PHST- 2025/06/07 00:00 [received] PHST- 2025/12/12 00:00 [revised] PHST- 2026/01/06 00:00 [accepted] PHST- 2026/02/20 00:32 [medline] PHST- 2026/01/19 01:03 [pubmed] PHST- 2026/01/18 18:05 [entrez] AID - S0033-3506(26)00008-9 [pii] AID - 10.1016/j.puhe.2026.106141 [doi] PST - ppublish SO - Public Health. 2026 Mar;252:106141. doi: 10.1016/j.puhe.2026.106141. Epub 2026 Jan 17. PMID- 41548363 OWN - NLM STAT- MEDLINE DCOM- 20260304 LR - 20260304 IS - 1573-2509 (Electronic) IS - 0920-9964 (Linking) VI - 289 DP - 2026 Mar TI - Prevalence and multidimensional impact of sarcopenia in schizophrenia: Associations with oxidative stress, functioning, and symptom severity. PG - 61-70 LID - S0920-9964(26)00002-2 [pii] LID - 10.1016/j.schres.2026.01.002 [doi] AB - OBJECTIVE: This study aimed to investigate the prevalence of sarcopenia in individuals with schizophrenia and examine its associations with oxidative stress, symptom severity, functioning, and quality of life. METHODS: A total of 198 schizophrenia patients aged 18-65 were assessed using the EWGSOP2 criteria for sarcopenia. Participants were classified as sarcopenic if they met criteria for probable, confirmed, or severe sarcopenia. Oxidative stress was evaluated using total antioxidant capacity (TAC), total oxidant status (TOS), and oxidative stress index (OSI). Clinical functioning, psychiatric symptoms, and quality of life were assessed using standardized psychometric tools. Multiple linear regression was conducted to identify predictors of oxidative stress parameters. RESULTS: Sarcopenia was identified in 66.6% of participants, with most meeting criteria for probable sarcopenia. Sarcopenic patients had significantly lower muscle mass, bone mass, basal metabolic rate, handgrip strength, and walking speed, along with poorer quality of life and functional scores. TAC positively correlated with muscle-related parameters and inversely with sarcopenia severity, while OSI showed negative correlations with physical health indicators. Sarcopenic patients also had more severe psychiatric symptoms. Regression analysis revealed that TAC was significantly predicted by BMI, the number of sarcopenia criteria met, PANSS-Total, and WHOQOL-BREF scores (R(2) = 0.10, p = .011). No significant differences were found in mean TAC, TOS, and OSI between sarcopenic and non-sarcopenic groups. CONCLUSION: Sarcopenia is highly prevalent and clinically relevant in individuals with schizophrenia, even at midlife. Routine screening and early interventions targeting physical health and oxidative stress may improve outcomes. CI - Copyright (c) 2026 Elsevier B.V. All rights reserved. FAU - Sisman, Ozgu AU - Sisman O AD - Department of Psychiatry, University of Health Sciences Bursa Faculty of Medicine, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkiye. Electronic address: ozgu.sisman@sbu.edu.tr. FAU - Onen, Sinay AU - Onen S AD - Department of Psychiatry, University of Health Sciences Bursa Faculty of Medicine, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa, Turkiye. Electronic address: sinay.onen@sbu.edu.tr. LA - eng PT - Journal Article DEP - 20260117 PL - Netherlands TA - Schizophr Res JT - Schizophrenia research JID - 8804207 SB - IM EIN - Schizophr Res. 2026 Mar;289:112. doi: 10.1016/j.schres.2026.01.017. PMID: 41611544 MH - Prevalence MH - *Sarcopenia/epidemiology/physiopathology/psychology MH - *Schizophrenia/complications/physiopathology MH - *Oxidative Stress/physiology MH - Severity of Illness Index MH - *Symptom Burden MH - Quality of Life MH - Regression Analysis MH - Cross-Sectional Studies MH - Humans MH - Male MH - Female MH - Adolescent MH - Young Adult MH - Adult MH - Middle Aged MH - Aged OTO - NOTNLM OT - Functioning OT - Oxidative stress OT - Quality of life OT - Sarcopenia OT - Schizophrenia COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/19 01:03 MHDA- 2026/02/15 00:31 CRDT- 2026/01/18 18:03 PHST- 2025/07/07 00:00 [received] PHST- 2025/12/18 00:00 [revised] PHST- 2026/01/06 00:00 [accepted] PHST- 2026/02/15 00:31 [medline] PHST- 2026/01/19 01:03 [pubmed] PHST- 2026/01/18 18:03 [entrez] AID - S0920-9964(26)00002-2 [pii] AID - 10.1016/j.schres.2026.01.002 [doi] PST - ppublish SO - Schizophr Res. 2026 Mar;289:61-70. doi: 10.1016/j.schres.2026.01.002. Epub 2026 Jan 17. PMID- 41548262 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260904 IS - 1878-5506 (Electronic) IS - 1389-9457 (Linking) VI - 140 DP - 2026 Apr TI - High night-to-night variability in childhood obstructive sleep apnea severity. PG - 108784 LID - S1389-9457(26)00022-5 [pii] LID - 10.1016/j.sleep.2026.108784 [doi] AB - STUDY: Overnight in-laboratory polysomnography is the gold standard test for childhood obstructive sleep apnea (OSA). Night-to-night variability is a well-documented phenomenon in adult literature but is poorly characterized in children. We evaluated the test-retest reliability of polysomnography in children with moderate-severe OSA. METHODS: This is a secondary analysis of two pediatric trials evaluating OSA therapies for children aged 4-18 years old with moderate-severe OSA. The baseline diagnostic polysomnography data were compared to repeat polysomnography data in trial. RESULTS: Twenty-seven children were included (median age 8 years, 41% females, body mass index z-score 1.4). The median inter-test interval was 48 days (range: 14-78 days). There were 7/27 children (26%) with moderate-severe OSA whose second polysomnography showed mild or no OSA. The median (interquartile range) obstructive apnea-hypopnea index on the first night was 9.4 (7.4-14.0) events/hour and 14.2 (5.4-21.6) events/hour on the second night, with poor correlation (intraclass correlation coefficient; ICC 0.27; 95% CI -0.04, 0.51; p = 0.080). There was poor correlation for the oxygen desaturation index (8.9 versus 10.9 events/hour; ICC 0.10; 95% CI -0.26, 0.53; p = 0.31), and poor correlation for hypoxic burden (31.9 versus 48.7 %min/hour; ICC 0.45; 95% CI 0.10, 0.70; p = 0.0072). CONCLUSION: Polysomnograms demonstrate poor test-retest reliability in children with moderate-severe OSA. There should be caution relying solely on a single night polysomnogram in children with moderate-severe OSA. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - Xiao, Lena AU - Xiao L AD - Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada; University of Toronto, Toronto, Canada; Department of Pediatrics, British Columbia Children's Hospital, Vancouver, Canada; University of British Columbia, Vancouver, Canada. Electronic address: lena.xiao@cw.bc.ca. FAU - Terrance, Mystica AU - Terrance M AD - Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada; University of Toronto, Toronto, Canada. Electronic address: mystica.terrance@sickkids.ca. FAU - Au, Chun Ting AU - Au CT AD - Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: jun.au@sickkids.ca. FAU - Massicotte, Colin AU - Massicotte C AD - Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada. Electronic address: colin.massicotte@sickkids.ca. FAU - Narang, Indra AU - Narang I AD - Department of Pediatrics, The Hospital for Sick Children, Toronto, Canada; University of Toronto, Toronto, Canada; Translational Medicine, Research Institute, The Hospital for Sick Children, Toronto, Ontario, Canada. Electronic address: indra.narang@sickkids.ca. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260114 PL - Netherlands TA - Sleep Med JT - Sleep medicine JID - 100898759 SB - IM MH - Humans MH - *Sleep Apnea, Obstructive/diagnosis/physiopathology/therapy MH - Female MH - *Polysomnography/methods MH - Child MH - Child, Preschool MH - Severity of Illness Index MH - Male MH - Reproducibility of Results MH - Adolescent OTO - NOTNLM OT - Children OT - Obstructive sleep apnea OT - Sleep-disordered breathing COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:Indra Narang reports financial support was provided by Physicians' Services Incorporated. Indra Narang reports financial support was provided by HSBC. Indra Narang reports equipment, drugs, or supplies was provided by Rematee. Indra Narang reports a relationship with Canadian Institutes of Health Research that includes: funding grants. Lena Xiao reports a relationship with The Hospital for Sick Children that includes: funding grants. Lena Xiao reports a relationship with American Thoracic Society that includes: funding grants. Lena Xiao reports a relationship with Baxter Healthcare Corporation that includes: funding grants. Lena Xiao reports a relationship with International Pediatric Sleep Association that includes: funding grants. Lena Xiao reports a relationship with Sleep Research Society Foundation that includes: funding grants. Lena Xiao reports a relationship with American College of Chest Physicians that includes: travel reimbursement. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/18 22:19 MHDA- 2026/02/22 05:35 CRDT- 2026/01/18 17:59 PHST- 2026/01/06 00:00 [received] PHST- 2026/01/13 00:00 [accepted] PHST- 2026/02/22 05:35 [medline] PHST- 2026/01/18 22:19 [pubmed] PHST- 2026/01/18 17:59 [entrez] AID - S1389-9457(26)00022-5 [pii] AID - 10.1016/j.sleep.2026.108784 [doi] PST - ppublish SO - Sleep Med. 2026 Apr;140:108784. doi: 10.1016/j.sleep.2026.108784. Epub 2026 Jan 14. PMID- 41548203 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260713 IS - 1552-7832 (Electronic) IS - 1043-6596 (Linking) VI - 37 IP - 3 DP - 2026 May TI - Perceived Cultural Competence in Postpartum Units: Perspectives of Culturally Diverse New Mothers Regarding Nurses and Implications for Breastfeeding. PG - 390-401 LID - 10.1177/10436596251410873 [doi] AB - INTRODUCTION: Globalization and rising immigration highlight the importance of culturally competent nursing care, yet global reports reveal persistent cultural insensitivity. This study explored how new mothers in postpartum units perceive nurses' cultural competence, examining its relationship to mothers' religious and cultural backgrounds and breastfeeding outcomes. METHOD: After obtaining ethical approval, 229 Israeli mothers (Hebrew or Arabic speakers) who gave birth to full-term infants participated. Data were collected via a validated 42-item questionnaire assessing perceived cultural competence, religiosity, cultural customs, breastfeeding, and demographics. Statistical analyses included Pearson's correlations, ANOVA, and regression. RESULTS: Older age, higher religiosity, more children, and associate degrees were linked to higher perceived nurse competence. The "skills" dimension of cultural competence was associated with positive perceptions. Higher perceived cultural competence correlated with full breastfeeding. DISCUSSION: Findings underscore the need to enhance nurses' cultural awareness and skills as part of routine postpartum care to improve maternal experience and outcomes. FAU - Zlatkin, Elena AU - Zlatkin E AD - Hadassah Hebrew University Medical Centre, Jerusalem, Israel. FAU - Gabay, Gillie AU - Gabay G AD - Achva Academic College, Shikmim, Israel. FAU - Shafran-Tikva, Sigal AU - Shafran-Tikva S AD - Hadassah Hebrew University Medical Centre, Jerusalem, Israel. AD - Jerusalem College of Technology, Israel. FAU - Segal, Ronit AU - Segal R AD - Hadassah Hebrew University Medical Centre, Jerusalem, Israel. FAU - Sela, Yaron AU - Sela Y AD - Reichman University, Herzliya, Israel. FAU - Goldstein, Libbie AU - Goldstein L AD - Hadassah Hebrew University Medical Centre, Jerusalem, Israel. FAU - Noble, Anita AU - Noble A AD - Hebrew University of Jerusalem, Israel. FAU - Alon, Rely AU - Alon R AD - Hadassah Hebrew University Medical Centre, Jerusalem, Israel. FAU - Zelker, Revital AU - Zelker R AUID- ORCID: 0000-0002-2122-4957 AD - Hadassah Hebrew University Medical Centre, Jerusalem, Israel. LA - eng PT - Journal Article DEP - 20260118 PL - United States TA - J Transcult Nurs JT - Journal of transcultural nursing : official journal of the Transcultural Nursing Society JID - 9001407 SB - IM MH - Humans MH - Female MH - *Breast Feeding/psychology/methods MH - *Cultural Competency/psychology MH - Adult MH - Surveys and Questionnaires MH - *Mothers/psychology/statistics & numerical data MH - Israel/ethnology MH - *Perception MH - *Cultural Diversity OTO - NOTNLM OT - breastfeeding OT - cultural competence OT - diversity OT - maternity nurses OT - new mothers OT - religiosity COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/01/18 22:19 MHDA- 2026/04/10 12:59 CRDT- 2026/01/18 11:52 PHST- 2026/04/10 12:59 [medline] PHST- 2026/01/18 22:19 [pubmed] PHST- 2026/01/18 11:52 [entrez] AID - 10.1177/10436596251410873 [doi] PST - ppublish SO - J Transcult Nurs. 2026 May;37(3):390-401. doi: 10.1177/10436596251410873. Epub 2026 Jan 18. PMID- 41548031 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jan 17 TI - Association between idiopathic scoliosis and facial asymmetry: a gender-balanced case-control study. PG - 6805 LID - 10.1038/s41598-026-36422-4 [doi] LID - 6805 AB - This study aimed to investigate the association between idiopathic scoliosis (IS) and facial asymmetry in a gender-balanced case-control design. Based on power analysis, 100 participants were recruited (50 IS patients: 25 male, 25 female; 50 controls: 25 male, 25 female). Facial asymmetry was evaluated through clinical examination and frontal cephalometric analysis. Statistical analysis was performed using chi-square tests and logistic regression, with post-hoc power calculation. Facial asymmetry was present in 41 (82%) of IS patients compared to 18 (36%) of controls (p < 0.001). The achieved power was 99% for detecting this difference. Among IS patients, 21 males (84%) and 20 females (80%) exhibited facial asymmetry. In controls, facial asymmetry was observed in 10 males (40%) and 8 females (32%). The odds ratio for facial asymmetry in IS patients was 7.64 (95% CI 3.02-19.32) compared to controls. Idiopathic scoliosis is significantly associated with facial asymmetry, with no substantial gender difference in this association. The high statistical power confirms the reliability of these findings. FAU - Taskin, Recep AU - Taskin R AUID- ORCID: 0000-0002-3656-6140 AD - Department of Orthopedics and Traumatology, Kastamonu University, 37100, Kastamonu, Turkey. FAU - Kalkan, Ergin AU - Kalkan E AUID- ORCID: 0000-0002-5544-1271 AD - Dentkastamonu Oral and Dental Health Clinic, 37100, Kastamonu, Turkey. kalkanergin@gmail.com. FAU - Ugur, Fatih AU - Ugur F AUID- ORCID: 0000-0001-6109-8425 AD - Department of Orthopedics and Traumatology, Kastamonu University, 37100, Kastamonu, Turkey. LA - eng PT - Journal Article DEP - 20260117 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Scoliosis/complications MH - Case-Control Studies MH - Male MH - Female MH - *Facial Asymmetry/complications/epidemiology MH - Adolescent MH - Cephalometry MH - Child MH - Sex Factors PMC - PMC12917111 OTO - NOTNLM OT - Case-control study OT - Cephalometry OT - Facial asymmetry OT - Gender differences OT - Idiopathic scoliosis OT - Power analysis COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Kastamonu University Ethics Committee (Date: 13.11.2025/Approval No: 2025-61). EDAT- 2026/01/18 00:37 MHDA- 2026/06/27 06:44 PMCR- 2026/01/17 CRDT- 2026/01/17 23:21 PHST- 2025/12/19 00:00 [received] PHST- 2026/01/13 00:00 [accepted] PHST- 2026/06/27 06:44 [medline] PHST- 2026/01/18 00:37 [pubmed] PHST- 2026/01/17 23:21 [entrez] PHST- 2026/01/17 00:00 [pmc-release] AID - 10.1038/s41598-026-36422-4 [pii] AID - 36422 [pii] AID - 10.1038/s41598-026-36422-4 [doi] PST - epublish SO - Sci Rep. 2026 Jan 17;16(1):6805. doi: 10.1038/s41598-026-36422-4. PMID- 41548020 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jan 17 TI - Prevalence and risk factors of stress urinary incontinence among female horseback riders in Poland. PG - 5606 LID - 10.1038/s41598-026-36444-y [doi] LID - 5606 AB - Stress urinary incontinence (SUI) is usually associated with aging and parity, but repetitive intra-abdominal pressure during physical activity can also trigger its onset in young women. Horseback riding, despite potential benefits for pelvic floor strengthening, may also contribute to pelvic floor strain and urinary symptoms. The study included 100 Polish women aged 21-54 engaged in horse riding, both recreational (85%) and professional (15%). Participants were divided into three age groups and screened for urinary incontinence symptoms. Quality of life was assessed with validated questionnaires (IIQ-7, UDI-6SF) and a custom 25-item survey covering equestrian practice, reproductive history, urinary symptoms, and general health. Statistical analyses were performed in R using non-parametric tests, correlation, and logistic regression. Stress urinary incontinence was reported by 36% of participants, significantly impairing quality of life. Women with higher BMI, older age, and childbirth history demonstrated increased symptom prevalence and higher IIQ-7 and UDI-6 scores (p < 0.05). Training type, frequency, and duration were not significantly associated with outcomes, except for shorter riding experience, which correlated with higher UDI-6 scores. Logistic regression identified age (OR = 1.07) and BMI (OR = 1.16) as risk factors, while greater height reduced SUI odds (OR = 0.92). Urinary incontinence is a relevant issue among female horse riders, negatively affecting physical, social, and emotional well-being. Age, BMI and childbirth history play crucial roles in the incidence of SUI symptoms. The longer the training experience, the lower is reported urinary incontinence distress. Preventive measures such as pelvic floor training, individualized physiotherapy, and interdisciplinary care may reduce symptom burden and support longer professional activity. Raising awareness and encouraging early intervention are essential to improving athletes' quality of life. CI - (c) 2026. The Author(s). FAU - Zalewski, Maciej AU - Zalewski M AD - Department of Gynaecology, Independent Public Health Care Center of the Ministry of the Interior and Administration in Wroclaw, Wroclaw, Poland. AD - Department of Gynaecology and Obstetrics, Faculty of Health Sciences, Medical University of Wroclaw, Wroclaw, Poland. FAU - Kolodynska, Gabriela AU - Kolodynska G AD - Department of Physiotherapy, Wroclaw University of Health and Sport Sciences, al. I. Paderewskiego 35, 51-612, Wroclaw, Poland. gabriela.kolodynska@awf.wroc.pl. FAU - Piatek, Aleksandra AU - Piatek A AD - Department of Gynaecology, Independent Public Health Care Center of the Ministry of the Interior and Administration in Wroclaw, Wroclaw, Poland. FAU - Mucha, Anna AU - Mucha A AD - Department of Genetics, Wroclaw University of Environmental and Life Sciences, Wroclaw, Poland. FAU - Misztela, Wiktoria AU - Misztela W AD - Department of Physiotherapy, Wroclaw University of Health and Sport Sciences, al. I. Paderewskiego 35, 51-612, Wroclaw, Poland. FAU - Andrzejewski, Waldemar AU - Andrzejewski W AD - Department of Physiotherapy, Wroclaw University of Health and Sport Sciences, al. I. Paderewskiego 35, 51-612, Wroclaw, Poland. LA - eng PT - Journal Article DEP - 20260117 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Female MH - Humans MH - Poland/epidemiology MH - *Urinary Incontinence, Stress/epidemiology/etiology MH - Adult MH - Risk Factors MH - Prevalence MH - Quality of Life MH - Middle Aged MH - Animals MH - Horses MH - Surveys and Questionnaires MH - Young Adult MH - Pelvic Floor/physiopathology MH - Sports PMC - PMC12891647 OTO - NOTNLM OT - Female horseback riders OT - Quality of life OT - Stress urinary incontinence COIS- Declarations. Competing interests: The authors declare no competing interests. Informed consent: Informed consent was obtained from all subjects involved in the study. Institutional review board statement: The study was approved by the Bioethics Committee of the Medical University of Wroclaw number KB - 806/2018. EDAT- 2026/01/18 00:37 MHDA- 2026/02/11 00:39 PMCR- 2026/01/17 CRDT- 2026/01/17 23:20 PHST- 2025/08/26 00:00 [received] PHST- 2026/01/13 00:00 [accepted] PHST- 2026/02/11 00:39 [medline] PHST- 2026/01/18 00:37 [pubmed] PHST- 2026/01/17 23:20 [entrez] PHST- 2026/01/17 00:00 [pmc-release] AID - 10.1038/s41598-026-36444-y [pii] AID - 36444 [pii] AID - 10.1038/s41598-026-36444-y [doi] PST - epublish SO - Sci Rep. 2026 Jan 17;16(1):5606. doi: 10.1038/s41598-026-36444-y. PMID- 41547787 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jan 17 TI - Feasibility of dynamic structural equation modeling for capturing micro-level temporal dynamics in adolescent physical activity. PG - 345 LID - 10.1186/s12889-026-26321-8 [doi] LID - 345 AB - BACKGROUND: Worldwide, physical activity (PA) levels among adolescents remain insufficient, highlighting the need for effective interventions. To improve these efforts, a nuanced understanding of habitual PA patterns and their fluctuations is essential. This feasibility study demonstrates the application of Dynamic Structural Equation Modeling (DSEM) to analyze micro-level temporal dynamics in adolescent PA behavior. Building on data from Beck et al. (2024) (BMC Public Health), one-week diary-based activity records from 15 adolescents (8 boys, 7 girls; mean age = 13.04 +/- 1.28 years) were re-analyzed to examine: (1) the degree to which actual PA deviates from habitual PA, (2) the temporal dynamics of PA, and (3) the situational locus of control regulating these deviations. METHODS: Participants first outlined their usual weekly schedules and then documented their actual behaviors for one week. This intensive longitudinal design yielded 1,785 hourly observations and descriptive data of habitual and actual PA was analyzed. A two-stage analytic approach was employed. First, given the small sample (N = 15), we used an idiographic approach with DSEM to analyze each adolescent's longitudinal data, employing simple models to capture within-person dynamics and summarizing results descriptively by counting credible intervals excluding zero, stratified by gender. Second, situational locus of control underlying deviations from habitual PA was assessed using Pearson residuals. RESULTS: N-of-1 DSEM analyses showed that both habitual plans and actual activity were relatively stable, with strong autoregressive patterns, evening reductions, and consistent positive alignment between habitual PA and action; cross-lagged and weather effects were minimal, highlighting stable idiographic dynamics.Self-controlled increases in PA occurred mainly toward the end of school days and early weekend mornings, whereas self-controlled decreases were most prominent in late afternoons. CONCLUSION: This feasibility study highlights the utility of DSEM for modeling fine-grained behavioral dynamics in small adolescent samples. Findings underscore stable yet context-sensitive PA patterns and demonstrate DSEM's value as a methodological framework for future research on adolescent PA. FAU - Beck, Franziska AU - Beck F AD - Department of Sport Science and Sport, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Gebbertstrasse 123B, Erlangen, 91052, Germany. franzi.beck@fau.de. FAU - Reimers, Anne Kerstin AU - Reimers AK AD - Department of Sport Science and Sport, Friedrich-Alexander-Universitat Erlangen-Nurnberg, Gebbertstrasse 123B, Erlangen, 91052, Germany. FAU - Dettweiler, Ulrich AU - Dettweiler U AD - Norwegian Centre for Learning Environment and Behavioral Research in Education, University of Stavanger, Stavanger, 4036, Norway. LA - eng PT - Journal Article DEP - 20260117 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - Female MH - Feasibility Studies MH - *Exercise/psychology MH - Male MH - *Latent Class Analysis MH - *Adolescent Behavior/psychology MH - Longitudinal Studies MH - Time Factors MH - Internal-External Control PMC - PMC12849192 OTO - NOTNLM OT - Adolescents OT - Dynamic structural equation modeling OT - Feasibility study OT - Habitual behavior OT - Physical activity OT - Situational locus of control OT - Temporal dynamics COIS- Declarations. Ethics approval and consent to participate: The study was approved by the local Ethics Committee of the Friedrich- Alexander-Universitat Erlangen-Nurnberg (Ref. No. 23-31-S) and was in accordance with the 1964 Declaration of Helsinki. All participants or their legal guardians provided written informed consent for study participation. Participation in the study was voluntary and every participant received a gift worth 10 euro. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/18 00:37 MHDA- 2026/06/27 12:39 PMCR- 2026/01/17 CRDT- 2026/01/17 23:14 PHST- 2025/10/13 00:00 [received] PHST- 2026/01/12 00:00 [accepted] PHST- 2026/06/27 12:39 [medline] PHST- 2026/01/18 00:37 [pubmed] PHST- 2026/01/17 23:14 [entrez] PHST- 2026/01/17 00:00 [pmc-release] AID - 10.1186/s12889-026-26321-8 [pii] AID - 26321 [pii] AID - 10.1186/s12889-026-26321-8 [doi] PST - epublish SO - BMC Public Health. 2026 Jan 17;26(1):345. doi: 10.1186/s12889-026-26321-8. PMID- 41547746 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jan 17 TI - The mechanism of physical exercise and adolescent short-form video app addiction: the chain mediating role of autonomous motivation and mental health literacy. PG - 569 LID - 10.1186/s12889-026-26220-y [doi] LID - 569 AB - BACKGROUND: In the digital era, excessive use of short-form video applications (Apps) can exert numerous negative effects on the physical and mental health of adolescents. Physical exercise not only benefits physical health but also enhances intrinsic motivation levels and psychological regulation abilities. Therefore, this study aims to explore the association between Physical Exercise and Short-form Video App Addiction, as well as the mediating roles of Autonomous Motivation and Mental Health Literacy in the relationship between physical exercise and short-form video app addiction. METHODS: This study employed a combination of convenience sampling and stratified sampling to conduct a cross-sectional survey among 644 junior and senior high school students. The cross-sectional nature of the data limits causal inference. Measurements included the Physical Activity Rating Scale, Autonomous Motivation Scale, Mental Health Literacy Scale, and Short-form Video App Addiction Scale. Data analysis was performed using AMOS 24, SPSS 27.0, and PROCESS 4.1 for reliability and validity assessment, descriptive statistics, correlation analysis, and mediation analysis. RESULTS: (1) Physical exercise showed a statistically significant negative correlation with adolescent short-form video app addiction; (2) Both autonomous motivation and mental health literacy independently mediated the relationship between physical exercise and adolescent short-form video App addiction; (3) Autonomous motivation and mental health literacy played a chain mediating role between physical exercise and adolescent short-form video App addiction. CONCLUSION: Physical exercise is negatively associated with adolescent short-form video app addiction, while also positively associated with autonomous motivation and mental health literacy. High levels of autonomous motivation and mental health literacy are associated with lower levels of short-form video app addiction. Based on these association patterns, we suggest that schools and families, in holistic practices promoting adolescent health development, should emphasize the integration of physical exercise, autonomous motivation development, and mental health literacy enhancement. This comprehensive health promotion approach may provide a reference for future research exploring how to promote healthy digital media use habits among adolescents. It should be noted that the directionality of the aforementioned associations and their potential intervention effects still require further validation through longitudinal tracking or experimental studies. CI - (c) 2026. The Author(s). FAU - Wu, Chengyi AU - Wu C AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Wang, Xianliang AU - Wang X AD - School of Physical Education, Shandong University, Jinan, 250061, China. wangxianliang@sdu.edu.cn. FAU - Zhang, Ying AU - Zhang Y AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Ma, Chao AU - Ma C AD - School of Physical Education, Shandong University, Jinan, 250061, China. FAU - Deng, Yiran AU - Deng Y AD - School of Physical Education, Shandong University, Jinan, 250061, China. LA - eng GR - 31130005442101/National Key Research and Development Program of China/ PT - Journal Article DEP - 20260117 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Health Literacy/statistics & numerical data MH - Adolescent MH - *Motivation MH - *Exercise/psychology MH - Female MH - Cross-Sectional Studies MH - Male MH - *Behavior, Addictive/psychology MH - *Mobile Applications/statistics & numerical data MH - *Mental Health MH - Surveys and Questionnaires PMC - PMC12895814 OTO - NOTNLM OT - Adolescents OT - Autonomous motivation OT - Mental health literacy OT - Physical exercise OT - Short-form video app addiction COIS- Declarations. Ethics approval and consent to participate: This study involved human participants and was approved by the Ethics Committee of the School of Basic Medical Sciences, Shandong University (ECSBMSSDU2024-1-141).The study was conducted in accordance with the Declaration of Helsinki. Participants and their parents or legal guardians have provided written informed consent to participate in this study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/18 00:37 MHDA- 2026/02/12 06:54 PMCR- 2026/01/17 CRDT- 2026/01/17 23:13 PHST- 2025/10/01 00:00 [received] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/02/12 06:54 [medline] PHST- 2026/01/18 00:37 [pubmed] PHST- 2026/01/17 23:13 [entrez] PHST- 2026/01/17 00:00 [pmc-release] AID - 10.1186/s12889-026-26220-y [pii] AID - 26220 [pii] AID - 10.1186/s12889-026-26220-y [doi] PST - epublish SO - BMC Public Health. 2026 Jan 17;26(1):569. doi: 10.1186/s12889-026-26220-y. PMID- 41547397 OWN - NLM STAT- MEDLINE DCOM- 20260726 LR - 20260726 IS - 1885-5857 (Electronic) IS - 1885-5857 (Linking) VI - 79 IP - 8 DP - 2026 Aug TI - Aortic coartation stenting in young population: height matters. PG - 670-679 LID - S1885-5857(26)00005-8 [pii] LID - 10.1016/j.rec.2025.12.018 [doi] AB - INTRODUCTION AND OBJECTIVES: Stent implantation is an established treatment for aortic coarctation (CoA) in adults. In pediatric patients, however, ongoing somatic growth necessitates repeated stent redilations, and the optimal timing of these procedures remains undefined. This retrospective study aimed to identify an objective association between stent diameter and body growth parameters, thereby providing a basis for prognostic assessment and structured planning of redilation strategies. METHODS: In the derivation cohort, all stent implantations and redilations performed in 155 patients younger than 20 years with CoA at a tertiary center were analyzed (218 interventions; median age 10.1 years, IQR, 3.4-14.4). The findings were subsequently validated in an independent validation cohort from another tertiary center, comprising 198 patients (323 interventions; median age 7.5 years, IQR, 1.3-14.6). RESULTS: To assess the association between stent diameter and body growth parameters, correlation analyses were performed. Despite interindividual variability, a significant linear correlation between stent diameter and body height was identified (tau: 0.737, P 0.1 were genotyped in 674 non-syndromic CHD cases (including 449 families) and 356 pooled controls. The data were analyzed for case-control associations, parental transmission patterns, and correlations with nutritional status. RESULTS: Among the genetic variants analyzed, rs2236225 showed a strong allelic association with congenital heart disease (CHD) across all cases (A vs. G, p = 0.0003; OR = 1.4 [95% CI: 1.17-1.69]). This association was primarily driven by the 'A' allele, which emerged as a significant risk factor, especially within the acyanotic subgroup (A vs. G, p = 0.0001; OR = 1.47 [95% CI: 1.20-1.79]), and more specifically in ventricular septal defect (VSD) cases (A vs. G, p = 0.0003; OR = 1.5 [95% CI: 1.20-1.89]). A homozygous excess of genotypes was observed in Acyanotic group (AA vs GG, p = 0.0001; OR = 2.27[95% CI: 1.5 horizontal line 3.43]. Other Allelic association with ASD (p = 0.04); TOF (p = 0.02) and cyanotic group (p = 0.05) along with other genetic models was also noted. These findings underscore the potential involvement of rs2236225 in CHD pathogenesis and warrant further investigation into its clinical relevance. The MTHFR haplotype rs1801131-rs1801133 (CA) showed a significant association with CHD in both case-control and transmission disequilibrium analyses (p = 0.03), although neither SNP was independently significant. The common allele of rs1805087 was associated with CHD overall (p = 0.007; AG vs. AA), with a stronger effect observed in cyanotic cases (p = 0.005). Furthermore, this allele showed significant associations with maternal transmission (p = 0.01) and folic acid supplementation (p = 0.02), suggesting a gene-environment interaction. The rare allele of rs526934 exibited a dominant effect in acyanotic CHD cases (GG + AG vs. AA, p = 0.004). It also showed significant associations under a dominant model in VSD (p = 0.01) and ASD (p = 0.03). CONCLUSION: This dual-model study from North India offers a comprehensive evaluation of functional folate pathway gene variants in a large CHD cohort and suggest a complex interplay between genetic susceptibility and environmental factors, supporting a polygenic or gene-environment interaction model. Further validation in larger, well-characterized cohorts, incorporating additional variants, is essential to clarify the contribution of folate pathway polymorphisms to CHD aetiology. FAU - Kukshal, Prachi AU - Kukshal P AD - Sri Sathya Sai Sanjeevani Research Centre, Palwal, Haryana, India. prachi7k@gmail.com. FAU - Ahamad, Shadab AU - Ahamad S AD - Sri Sathya Sai Sanjeevani Research Centre, Palwal, Haryana, India. FAU - Joshi, Radha AU - Joshi R AD - Sri Sathya Sai Sanjeevani Research Centre, Palwal, Haryana, India. AD - Sri Sathya Sai Sanjeevani Research Centre, Kharghar, Maharashtra, India. FAU - Kumar, Ajay AU - Kumar A AD - Sri Sathya Sai Sanjeevani Research Centre, Palwal, Haryana, India. FAU - Chellappan, Subramanian AU - Chellappan S AD - Sri Sathya Sai Sanjeevani International Centre for Child Heart Care & Research, Palwal, Haryana, India. LA - eng PT - Journal Article DEP - 20260117 PL - England TA - BMC Cardiovasc Disord JT - BMC cardiovascular disorders JID - 100968539 RN - 935E97BOY8 (Folic Acid) RN - EC 1.5.1.20 (Methylenetetrahydrofolate Reductase (NADPH2)) RN - EC 1.5.1.20 (MTHFR protein, human) RN - EC 2.1.1.13. (MTR protein, human) RN - EC 1.5.1.5 (MTHFD1 protein, human) RN - EC 2.1.1.13 (5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase) RN - EC 1.5.1.5 (Methylenetetrahydrofolate Dehydrogenase (NADP)) RN - 0 (Minor Histocompatibility Antigens) SB - IM MH - Humans MH - *Heart Defects, Congenital/genetics/diagnosis/epidemiology MH - India/epidemiology MH - *Folic Acid/metabolism MH - Genetic Predisposition to Disease MH - *Methylenetetrahydrofolate Reductase (NADPH2)/genetics MH - Female MH - Phenotype MH - Gene Frequency MH - *Polymorphism, Single Nucleotide MH - Case-Control Studies MH - Risk Factors MH - *5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase/genetics MH - *Methylenetetrahydrofolate Dehydrogenase (NADP)/genetics MH - Genetic Association Studies MH - Homozygote MH - Haplotypes MH - Nutritional Status MH - Risk Assessment MH - Minor Histocompatibility Antigens PMC - PMC12895914 OTO - NOTNLM OT - Case-Control association OT - Congenital Heart Disease OT - Folate polymorphisms OT - North India OT - Transmission disequilibrium test COIS- Declarations. Ethics approval and consent to participate: Ethics approval in accordance with the Declaration of Helsinki from Institutional Ethics Committee (IEC), Sri Sathya Sai Sanjeevani Research Foundation (SSSSRF) was taken for the study (PSR00005/2/IEC/8/2019). Written informed consent was obtained for all participants and parents/guardians, and assent was provided by children above 8 years of age as per IEC, SSSSRF and Indian Council of Medical Research (ICMR) guidelines. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/17 00:36 MHDA- 2026/06/27 12:36 PMCR- 2026/01/17 CRDT- 2026/01/16 23:27 PHST- 2025/04/14 00:00 [received] PHST- 2025/09/04 00:00 [accepted] PHST- 2026/06/27 12:36 [medline] PHST- 2026/01/17 00:36 [pubmed] PHST- 2026/01/16 23:27 [entrez] PHST- 2026/01/17 00:00 [pmc-release] AID - 10.1186/s12872-025-05194-6 [pii] AID - 5194 [pii] AID - 10.1186/s12872-025-05194-6 [doi] PST - epublish SO - BMC Cardiovasc Disord. 2026 Jan 17;26(1):141. doi: 10.1186/s12872-025-05194-6. PMID- 41545738 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20261012 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 2 DP - 2026 Jan 16 TI - Oral neonatal vitamin K deficiency bleeding prophylaxis in Switzerland (2018-2024), still valid guidelines for healthy infants. PG - 82 LID - 10.1007/s00431-025-06730-4 [doi] LID - 82 AB - Vitamin K (VK) deficiency is a condition that puts newborn infants at increased risk of vitamin K deficiency bleeding (VKDB) during the first 6 months of life. In Switzerland, current prophylactic guidelines have been shown to prevent VKDB effectively in healthy infants. They were implemented in 2003 and prescribe oral administration of VK (2 mg oral Konakion(R) MM (mixt micellar) hour 4, day 4, and week 4). As prophylaxis parental refusal has been increasingly reported, we prospectively tested the Swiss VKDB prophylaxis validity using a nationwide surveillance program (Swiss Paediatric Surveillance Unit) designed to detect all hospitalized VKDB cases. During 6 years (September 1, 2018, until August 31, 2024), nine VKDB cases were reported for 505,708 live births (1.78/10(5), 95% CI 0.81/10(5)-3.38/10(5)). All infants were exclusively breast fed and had VKDB risk factors such as parental VK refusal and/or cholestasis. Both Swiss VKDB 2018-2024 and 2005-2011 incidences were similar. CONCLUSION: The Swiss VKDB prophylactic guidelines are still valid and effective for healthy infants if applied appropriately. WHAT IS KNOWN: * Infantile vitamin K deficiency bleeding (VKDB) can be prevented by either intramuscular or oral VK administration in healthy infants. * Parental VK prophylaxis refusal (reported as increasing in frequency) as well as unrecognized cholestasis are main risk factors for VKDB. WHAT IS NEW: * Switzerland's 2003 VKDB prophylactic regimen (2 mg oral Konakion(R) MM (hour 4, day 4, and week 4) remains a valid recommendation for healthy infants. * Again, parental VK prophylaxis refusal and/or unrecognized cholestasis remain risk factors for VKDB. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Laubscher, Bernard AU - Laubscher B AUID- ORCID: 0000-0002-3850-1308 AD - Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. bernard.laubscher@bluewin.ch. AD - Division of Pediatrics, Department Women-Mother-Child, Lausanne University Hospital (CHUV), Rue du Bugnon 50, CH-1011, Lausanne, Switzerland. bernard.laubscher@bluewin.ch. AD - Department of Pediatrics, Reseau Hospitalier Neuchatelois, Neuchatel, Switzerland. bernard.laubscher@bluewin.ch. FAU - Schubiger, Gregor AU - Schubiger G AUID- ORCID: 0009-0005-4201-4480 AD - , Rischstrasse 3, Ebikon, Switzerland. FAU - Rizzi, Mattia AU - Rizzi M AUID- ORCID: 0000-0001-6987-0678 AD - Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland. AD - Pediatric Hematology-Oncology Unit, Division of Pediatrics, Department Woman-Mother-Child, Lausanne University Hospital (CHUV), Lausanne, Switzerland. AD - Istituto Pediatrico Della Svizzera Italiana (IPSI), Ente Ospedaliero Cantonale E Universita Della Svizzera Italiana (USI), Servizio d'Emato-Oncologia Pediatrica, Bellinzona, Svizzera, Switzerland. CN - Swiss Paediatric Surveillance Unit (SPSU) LA - eng PT - Journal Article DEP - 20260116 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 12001-79-5 (Vitamin K) SB - IM MH - Humans MH - *Vitamin K Deficiency Bleeding/prevention & control/epidemiology MH - Switzerland/epidemiology MH - Infant, Newborn MH - Female MH - Male MH - *Practice Guidelines as Topic MH - Prospective Studies MH - Administration, Oral MH - Infant MH - *Vitamin K/administration & dosage MH - Risk Factors PMC - PMC13652918 OTO - NOTNLM OT - Bleeding OT - Infant OT - Newborn OT - Prophylaxis OT - Vitamin K OT - Vitamin K deficiency bleeding COIS- Declarations. Ethics approval: The study was approved by our local Institutional Review Board in accordance with the Declaration of Helsinki (Commission cantonale d'ethique de la recherche sur l'etre humain, CER-VD, 2018-00778). Consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/17 00:36 MHDA- 2026/01/17 00:37 PMCR- 2026/01/16 CRDT- 2026/01/16 23:24 PHST- 2025/09/17 00:00 [received] PHST- 2025/12/29 00:00 [accepted] PHST- 2025/12/01 00:00 [revised] PHST- 2026/01/17 00:37 [medline] PHST- 2026/01/17 00:36 [pubmed] PHST- 2026/01/16 23:24 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - 10.1007/s00431-025-06730-4 [pii] AID - 6730 [pii] AID - 10.1007/s00431-025-06730-4 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jan 16;185(2):82. doi: 10.1007/s00431-025-06730-4. PMID- 41545736 OWN - NLM STAT- MEDLINE DCOM- 20260116 LR - 20260920 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 2 DP - 2026 Jan 16 TI - Change in salivary cortisol levels in children (aged 9-12 years) with obesity and respiratory diseases during a 28-day spa treatment: a pilot prospective study. PG - 83 LID - 10.1007/s00431-025-06723-3 [doi] LID - 83 AB - Evidence on the neuroendocrine effects of pediatric spa treatment remains limited. Salivary cortisol is a validated, non-invasive biomarker of hypothalamic-pituitary-adrenal (HPA) axis activity, which may serve as an indicator of physiological adaptation to structured environmental and behavioral interventions. To determine whether a standardized 28-day spa treatment is associated with changes in morning salivary cortisol in children aged 9-12 years with obesity or chronic respiratory diseases, and to compare cortisol trajectories in these diagnostic groups with those of healthy controls. This prospective observational study included 95 children undergoing spa treatment and 38 school-based healthy controls assessed 24 days apart. Morning saliva (07:45-08:30) was analyzed using a validated LC-MS/MS method. Cortisol was successfully measured in 34 of 36 children with obesity, 18 of 50 children with respiratory diseases not receiving corticosteroids, and 36 of 38 healthy controls. Somatic and functional assessments were performed across the clinical cohort. Children with obesity showed a significant decrease in morning salivary cortisol (3.32 --> 2.36 nmol/L; mean change - 0.96 nmol/L; p = 0.004; d = - 0.54). Children with respiratory diseases showed a mild, non-significant increase (2.68 --> 3.48 nmol/L; + 0.80 nmol/L; p = 0.057; d = 0.47). Healthy controls showed a small increase (3.52 --> 4.02 nmol/L; + 0.50 nmol/L; p = 0.089; d = 0.25). Cortisol trajectories were broadly consistent with functional improvements within the spa cohort. Between-group differences should be interpreted in the context of natural variability and environmental factors influencing the school-based control population. CONCLUSIONS: Diagnosis-dependent changes in morning salivary cortisol were observed during a 28-day spa treatment program. The decrease in children with obesity and the mild increase in those with respiratory diseases may indicate differing patterns of physiological adaptation. These findings support the feasibility of incorporating salivary cortisol into future controlled pediatric trials aimed at evaluating neuroendocrine responses to spa therapy. WHAT IS KNOWN: * Salivary cortisol is a validated, non-invasive biomarker of hypothalamic-pituitary-adrenal (HPA) axis activity and is widely used in pediatric research on stress regulation. * Spa treatment (balneotherapy) combines environmental and behavioral components, yet biomarker-based studies have been conducted almost exclusively in adults. Evidence from pediatric spa populations is currently lacking. WHAT IS NEW: * This pilot study provides the first pediatric data on morning salivary cortisol measured before and after a structured 28-day spa treatment program. * These findings offer initial effect-size estimates and suggest that morning salivary cortisol may be feasible to incorporate as a non-invasive marker in future controlled pediatric studies assessing physiological adaptation during spa treatment. CI - (c) 2026. The Author(s). FAU - Triskala, Z AU - Triskala Z AUID- ORCID: 0000-0002-7596-3085 AD - Charles University in Prague, Faculty of Medicine in Plzen, Jahodova 2889/42, Zabehlice, 106 00. Praha 10, Hlavni mesto, Prague, Czech Republic. Zdenek.Triskala@mzd.gov.cz. FAU - Jandova, D AU - Jandova D AD - Institute for Postgraduate Medical Education (IPVZ), Prague, Czech Republic. FAU - Hill, M AU - Hill M AD - Institute of Endocrinology, Department of Steroids and Proteofactors, Prague, Czech Republic. FAU - Bicikova, M AU - Bicikova M AD - Institute of Endocrinology, Department of Steroids and Proteofactors, Prague, Czech Republic. FAU - Macova, L AU - Macova L AD - Institute of Endocrinology, Department of Steroids and Proteofactors, Prague, Czech Republic. LA - eng PT - Journal Article PT - Observational Study DEP - 20260116 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - WI4X0X7BPJ (Hydrocortisone) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Hydrocortisone/metabolism/analysis MH - Child MH - *Saliva/chemistry/metabolism MH - Pilot Projects MH - Prospective Studies MH - Male MH - Female MH - Biomarkers/metabolism/analysis MH - *Pediatric Obesity/therapy/metabolism MH - Case-Control Studies MH - Hypothalamo-Hypophyseal System MH - Pituitary-Adrenal System MH - *Respiratory Tract Diseases/therapy/metabolism PMC - PMC12811273 OTO - NOTNLM OT - Balneotherapy OT - Biomarkers OT - Children OT - HPA axis OT - Obesity OT - Respiratory diseases OT - Salivary cortisol COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the principles of the Declaration of Helsinki. Ethical approval was obtained from the Ethics Committee of the Institute of Endocrinology (Prague, Czech Republic). Written informed consent was obtained from all parents or legal guardians of participating children prior to enrolment. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/17 00:36 MHDA- 2026/01/17 00:37 PMCR- 2026/01/16 CRDT- 2026/01/16 23:24 PHST- 2025/08/28 00:00 [received] PHST- 2025/12/22 00:00 [accepted] PHST- 2025/12/06 00:00 [revised] PHST- 2026/01/17 00:37 [medline] PHST- 2026/01/17 00:36 [pubmed] PHST- 2026/01/16 23:24 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - 10.1007/s00431-025-06723-3 [pii] AID - 6723 [pii] AID - 10.1007/s00431-025-06723-3 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jan 16;185(2):83. doi: 10.1007/s00431-025-06723-3. PMID- 41545536 OWN - NLM STAT- MEDLINE DCOM- 20260924 LR - 20261009 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 2 DP - 2026 Jan 16 TI - Medical comorbidities in autistic children: prevalence, sex-specific clustering, and network patterns at diagnosis in a Chilean cohort. PG - 85 LID - 10.1007/s00431-025-06739-9 [doi] AB - Medical comorbidities are common in autistic children, yet patterns of co-occurrence at diagnosis-particularly in under-researched regions-remain poorly characterized. We examined the prevalence, distribution, temporal trends, and sex-specific clustering of medical comorbidities at ASD diagnosis in a large Chilean cohort. We performed a retrospective chart review of 544 children diagnosed with ASD between 2015 and 2023 at a specialized pediatric neurodevelopmental center. Comorbidities were identified through standardized caregiver interviews, clinical examination, anthropometric assessment, and clinician-verified medical record review. Analyses included prevalence estimates, temporal trends, and sex-stratified exploratory network analysis. At least one comorbidity was present in 90% of children. The most frequent were insomnia (61%), overweight (52%), allergic rhinitis/atopic dermatitis (28%), and constipation (27%). Underweight prevalence declined significantly over time (from 11% to 5%; p = 0.028), whereas other conditions remained stable. Exploratory network analysis showed high connectivity in both sexes, with denser clustering in girls. In boys, insomnia, overweight, constipation, and allergic disorders formed the main cluster; in girls, allergic disorders remained central, while underweight showed more limited connectivity within the network. Demographic characteristics did not differ between children with and without additional medical conditions. CONCLUSION: Medical comorbidities are highly prevalent at the time of ASD diagnosis, with distinct sex-specific co-occurrence patterns that may guide early screening priorities. These findings support systematic, multidisciplinary assessment during the diagnostic process and highlight the need for longitudinal, multicenter studies to validate comorbidity clusters and clarify their developmental trajectories. WHAT IS KNOWN: * Autistic children frequently have medical comorbidities such as sleep, nutritional, gastrointestinal, and allergic disorders. * The prevalence of individual comorbidities is documented, but patterns of co-occurrence at diagnosis-particularly in Latin American cohorts-remain understudied. WHAT IS NEW: * In a large Chilean cohort of autistic children, 90% had >/=1 clinician-verified medical comorbidity at ASD diagnosis. * Sex-stratified exploratory network analysis showed a shared central cluster (insomnia, overweight, constipation, and ARAD), with higher overall connectivity in girls; underweight and epilepsy showed more limited connectivity at diagnosis. CI - (c) 2026. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Lopez-Espejo, Mauricio AU - Lopez-Espejo M AUID- ORCID: 0000-0003-4278-9188 AD - Section of Pediatric Neurology, Division of Pediatrics, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile. malopez5@uc.cl. AD - Neurodevelopment Unit, UC CHRISTUS Health Network, Santiago, Chile. malopez5@uc.cl. FAU - Nunez, Alicia AU - Nunez A AD - Section of Pediatric Neurology, Division of Pediatrics, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile. AD - Neurodevelopment Unit, UC CHRISTUS Health Network, Santiago, Chile. LA - eng PT - Journal Article DEP - 20260116 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Cohort Studies MH - Chile/epidemiology MH - Autistic Disorder/epidemiology MH - Comorbidity MH - Prevalence MH - Retrospective Studies MH - Humans MH - Male MH - Female MH - Child, Preschool MH - Sex Factors MH - Sex Distribution MH - Constipation/epidemiology MH - Sleep Initiation and Maintenance Disorders/epidemiology MH - Overweight/epidemiology MH - Asthma/epidemiology MH - *Autism Spectrum Disorder/diagnosis/epidemiology OTO - NOTNLM OT - Autism OT - Immune system diseases OT - Nutrition disorders OT - Sleep-wake disorders COIS- Declarations. Ethics approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of the Faculty of Medicine (CEC-Salud) of the Pontifical Catholic University of Chile (ID: 200601006). Consent to participate: N/A. Consent for publication: N/A. Competing interests: The authors declare no competing interests. EDAT- 2026/01/17 00:37 MHDA- 2026/01/17 00:38 CRDT- 2026/01/16 23:19 PHST- 2025/08/11 00:00 [received] PHST- 2025/12/30 00:00 [accepted] PHST- 2025/11/14 00:00 [revised] PHST- 2026/01/17 00:38 [medline] PHST- 2026/01/17 00:37 [pubmed] PHST- 2026/01/16 23:19 [entrez] AID - 10.1007/s00431-025-06739-9 [pii] AID - 10.1007/s00431-025-06739-9 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jan 16;185(2):85. doi: 10.1007/s00431-025-06739-9. PMID- 41545253 OWN - NLM STAT- MEDLINE DCOM- 20260527 LR - 20260601 IS - 1873-5010 (Electronic) IS - 1569-1993 (Linking) VI - 25 IP - 3 DP - 2026 May TI - Children with cystic fibrosis have an early-life disparity in fecal short chain fatty acid concentrations. PG - 513-520 LID - S1569-1993(26)00002-0 [pii] LID - 10.1016/j.jcf.2026.01.002 [doi] AB - BACKGROUND: The depletion of short chain fatty acid (SCFA) producing bacterial species in cystic fibrosis (CF) is hypothesized to reduce overall SCFA production, contributing to the onset and persistence of gastrointestinal inflammation. METHODS: In a prospective longitudinal observational study, we compared children with CFto age-matched healthy controls (HC). Participants completed a validated food frequency questionnaire and provided fecal samples for SCFA analysis (targeted liquid chromatography-mass spectrometry (LC-MS)), fecal calprotectin, and microbial community composition (16S rRNA gene sequencing). RESULTS: 64 children with CF (cwCF) [median age (IQR) = 8.4 (4-11.9)] and 64 HC [median age (IQR) = 7.8 (3.4-13.4)] were recruited. Valerate and isobutyrate were significantly reduced and more variable over time in cwCF compared to HC. Age-associated increases in butyrate, valerate, isobutyrate and isovalerate observed in HC, were absent in CF. In CF, butyrate was positively correlated with alpha diversity (Richness = 0.3, p = 0.0005; Shannon diversity = 0.3, p = 0.0005) and inversely correlated with elevated calprotectin concentrations (-0.34, p = 0.01). CwCF had higher relative intake of fats, predominated by trans and saturated fats, alongside reduced relative intake of fibre, wholegrains and resistant starch. CONCLUSIONS: Our findings indicate that reduced microbial diversity, depletion of key SCFA-producing taxa, and limited dietary fibre intake may promote alternative, less efficient pathways of butyrate synthesis in cwCF. When butyrate is reduced, heightened inflammation is more likely. Further investigation into the physiological roles of valerate and isobutyrate is needed to understand the implications of their depletion in CF. CI - Copyright (c) 2026. Published by Elsevier B.V. FAU - van Dorst, Josie AU - van Dorst J AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. Electronic address: j.vandorst@unsw.edu.au. FAU - Uthpala Pushpakumara, B L D AU - Uthpala Pushpakumara BLD AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. FAU - Katz, Tamarah AU - Katz T AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Sydney Children's Hospital Randwick, Department of Nutrition and Dietetics, Randwick, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. FAU - Hudson, Jennifer AU - Hudson J AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. FAU - Ting, Zi AU - Ting Z AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. FAU - McKay, Isabelle AU - McKay I AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. FAU - Tam, Rachel Y AU - Tam RY AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. FAU - Chan, Christopher AU - Chan C AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. FAU - Coffey, Michael AU - Coffey M AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Department of Gastroenterology, Sydney Children's Hospital, Randwick, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. FAU - Ooi, Chee Y AU - Ooi CY AD - School of Clinical Medicine, Discipline of Paediatrics & Child Health, UNSW Medicine & Health, UNSW Sydney, Australia; Department of Gastroenterology, Sydney Children's Hospital, Randwick, Australia; Sydney Children's Hospital, Department of Respiratory Medicine, Randwick, Australia. LA - eng PT - Journal Article PT - Observational Study DEP - 20260115 PL - Netherlands TA - J Cyst Fibros JT - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society JID - 101128966 RN - 0 (Fatty Acids, Volatile) RN - 0 (Leukocyte L1 Antigen Complex) SB - IM MH - Humans MH - *Cystic Fibrosis/microbiology/metabolism MH - *Feces/chemistry/microbiology MH - Female MH - *Fatty Acids, Volatile/analysis/metabolism MH - Male MH - Child MH - Prospective Studies MH - Longitudinal Studies MH - Child, Preschool MH - *Gastrointestinal Microbiome MH - Leukocyte L1 Antigen Complex/analysis MH - Adolescent OTO - NOTNLM OT - Butyrate OT - Calprotectin OT - Cystic fibrosis OT - Dysbiosis OT - Inflammation OT - Isobutyrate OT - Microbiota OT - Nutrition OT - Valerate COIS- Declaration of competing interest The authors report there are no conflicts of interest related to this work. EDAT- 2026/01/17 00:36 MHDA- 2026/05/28 00:29 CRDT- 2026/01/16 21:51 PHST- 2025/09/26 00:00 [received] PHST- 2025/12/09 00:00 [revised] PHST- 2026/01/03 00:00 [accepted] PHST- 2026/05/28 00:29 [medline] PHST- 2026/01/17 00:36 [pubmed] PHST- 2026/01/16 21:51 [entrez] AID - S1569-1993(26)00002-0 [pii] AID - 10.1016/j.jcf.2026.01.002 [doi] PST - ppublish SO - J Cyst Fibros. 2026 May;25(3):513-520. doi: 10.1016/j.jcf.2026.01.002. Epub 2026 Jan 15. PMID- 41544878 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260707 IS - 1878-5476 (Electronic) IS - 1469-0292 (Print) IS - 1878-5476 (Linking) VI - 83 DP - 2026 Mar TI - The Physical Activity Relatedness Satisfaction Scale: Assessing relatedness in those who prefer to be active alone and with others. PG - 103068 LID - S1469-0292(26)00008-7 [pii] LID - 10.1016/j.psychsport.2026.103068 [doi] AB - Relatedness, or the extent to which individuals feel connected to others, is one of three basic psychological needs postulated by self-determination theory (SDT). In physical activity contexts, the extent to which relatedness satisfaction is important for maintaining physical activity is unclear, and measurement challenges have hindered progress in the field. Specifically, many individuals prefer solitary physical activity, yet existing instruments assessing relatedness in physical activity are predominantly designed for group-based exercise settings. The purpose of this study was to develop and examine the psychometric properties of a new measure of relatedness for physical activity contexts, the Physical Activity Relatedness Satisfaction Scale (PARSS). Participants (N = 696) were recruited through an undergraduate psychology subject pool and random selection of patients in a health system. In a cross-sectional survey, participants completed PARSS test items, measures of basic need satisfaction, behavioral regulation, and self-reported physical activity. Analyses included exploratory and confirmatory factor analyses and correlations to establish construct and criterion validity. The final measure included 6 items contributing to one latent factor. The measure was invariant to participants' physical activity preferences and demonstrated high internal consistency reliability (alpha = .94) and evidence for construct and criterion validity (positive associations with other relatedness measures, autonomy and competence satisfaction, autonomous motivation and physical activity). The PARSS offers a reliable tool for observational studies exploring the relationship between relatedness satisfaction and physical activity, and for intervention research targeting relatedness as a mechanism for promoting physical activity behavior change. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Hooker, Stephanie A AU - Hooker SA AD - Research and Evaluation Division, HealthPartners Institute, 8170 33rd Ave S., MS 21112R, Minneapolis, MN, 55425, USA. Electronic address: stephanie.a.hooker@healthpartners.com. FAU - LaCaille, Lara J AU - LaCaille LJ AD - Department of Psychology, University of Minnesota Duluth, 320 BohH 1207 Ordean Court, Duluth, MN, 55812, USA. Electronic address: llacaill@d.umn.edu. FAU - LaCaille, Rick A AU - LaCaille RA AD - Department of Psychology, University of Minnesota Duluth, 320 BohH 1207 Ordean Court, Duluth, MN, 55812, USA. Electronic address: rlacaill@d.umn.edu. FAU - Sikorski, Jonathon AU - Sikorski J AD - TRIA Orthopedics, HealthPartners, 8100 Northland Dr, Bloomington, MN, 55431, USA. Electronic address: jonathon.sikorski@parknicollet.com. LA - eng GR - R21 AG070161/AG/NIA NIH HHS/United States PT - Journal Article DEP - 20260114 PL - Netherlands TA - Psychol Sport Exerc JT - Psychology of sport and exercise JID - 101088724 SB - IM MH - Humans MH - Female MH - Psychometrics MH - Male MH - *Personal Satisfaction MH - Reproducibility of Results MH - Personal Autonomy MH - Cross-Sectional Studies MH - *Exercise/psychology MH - Adult MH - Young Adult MH - Surveys and Questionnaires MH - Adolescent MH - Motivation MH - Factor Analysis, Statistical MH - Middle Aged MH - *Interpersonal Relations PMC - PMC12922672 MID - NIHMS2140389 OTO - NOTNLM OT - Basic psychological need OT - Exercise OT - Measurement OT - Reliability OT - Self-determination theory OT - Validity COIS- Declaration of competing interest The authors have no conflicts of interest to declare. EDAT- 2026/01/17 00:37 MHDA- 2026/01/24 00:32 PMCR- 2027/01/14 CRDT- 2026/01/16 19:14 PHST- 2025/09/04 00:00 [received] PHST- 2026/01/12 00:00 [revised] PHST- 2026/01/13 00:00 [accepted] PHST- 2026/01/24 00:32 [medline] PHST- 2026/01/17 00:37 [pubmed] PHST- 2026/01/16 19:14 [entrez] PHST- 2027/01/14 00:00 [pmc-release] AID - S1469-0292(26)00008-7 [pii] AID - 10.1016/j.psychsport.2026.103068 [doi] PST - ppublish SO - Psychol Sport Exerc. 2026 Mar;83:103068. doi: 10.1016/j.psychsport.2026.103068. Epub 2026 Jan 14. PMID- 41544039 OWN - NLM STAT- MEDLINE DCOM- 20260116 LR - 20260120 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 1 DP - 2026 TI - Supporting mental well-being of healthcare workers using a mobile app: A mixed-methods feasibility study. PG - e0341055 LID - 10.1371/journal.pone.0341055 [doi] LID - e0341055 AB - Poor mental well-being is common among healthcare workers, affecting individual health, patient safety, and organisational performance. Mobile app-based self-care interventions are promising due to their accessibility, low cost, and ease of use. This study aimed to assess the feasibility of a self-monitoring mobile app called MYARKEO, to improve mental well-being among healthcare workers and healthcare trainees in the United Kingdom (UK). The study evaluated recruitment and retention rates, variability of key outcomes to inform a future randomised controlled trial (RCT), intervention engagement, barriers and facilitators to engagement, and potential refinements to the mobile app. A mixed-method feasibility RCT was conducted with two groups: an intervention group using MYARKEO to monitor mental well-being over 6 weeks, and a non-intervention control group. Data were collected at baseline and post-intervention and included the Warwick-Edinburgh Mental Well-being Scale (WEMWBS), the Depression Anxiety and Stress Scale (DASS-21), and the mHealth App Usability Questionnaire (MAUQ). Qualitative data were collected through semi-structured interviews (n = 13) and analysed using thematic analysis. Forty-nine participants (32 workers, 17 trainees; aged 18-60+) were included in the trial, with a 20.5% dropout rate. Daily app usage averaged 64.5%. Participants frequently monitored mood, sleep, food, and exercise. Interviews identified themes of "Usefulness," "Enablers of engagement," "Barriers to engagement," and "Suggested intervention improvements." This study demonstrates the feasibility of using a mobile app to monitor and promote mental well-being among healthcare workers and trainees. While app engagement was promising, challenges were identified, highlighting the need for refinements to the app's content, interface, and design for future trials. CI - Copyright: (c) 2026 Yildirim et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Yildirim, Mehmet AU - Yildirim M AD - School of Health Sciences, University of Nottingham, Nottingham, United Kingdom. FAU - Carter, Timothy AU - Carter T AD - School of Health Sciences, University of Nottingham, Nottingham, United Kingdom. FAU - Blake, Holly AU - Blake H AUID- ORCID: 0000-0003-3080-2306 AD - School of Health Sciences, University of Nottingham, Nottingham, United Kingdom. AD - NIHR Nottingham Biomedical Research Centre, Nottingham, United Kingdom. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260116 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - *Mobile Applications MH - *Health Personnel/psychology MH - Adult MH - Female MH - Feasibility Studies MH - Male MH - *Mental Health MH - Middle Aged MH - United Kingdom MH - Young Adult MH - Surveys and Questionnaires MH - Telemedicine MH - Adolescent PMC - PMC12810850 COIS- The authors have declared that no competing interests exist. EDAT- 2026/01/16 19:24 MHDA- 2026/01/16 19:25 PMCR- 2026/01/16 CRDT- 2026/01/16 13:34 PHST- 2025/04/21 00:00 [received] PHST- 2025/12/31 00:00 [accepted] PHST- 2026/01/16 19:25 [medline] PHST- 2026/01/16 19:24 [pubmed] PHST- 2026/01/16 13:34 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - PONE-D-25-19125 [pii] AID - 10.1371/journal.pone.0341055 [doi] PST - epublish SO - PLoS One. 2026 Jan 16;21(1):e0341055. doi: 10.1371/journal.pone.0341055. eCollection 2026. PMID- 41543589 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260920 IS - 1436-6215 (Electronic) IS - 1436-6207 (Print) IS - 1436-6207 (Linking) VI - 65 IP - 1 DP - 2026 Jan 16 TI - Association between eating behaviours and food and beverage consumption in male and female children aged 3-6 years: The CORALS cohort. PG - 26 LID - 10.1007/s00394-025-03848-x [doi] LID - 26 AB - PURPOSE: Eating behaviours influence food intake and long-term eating habits. This study aimed to assess the association between specific eating behaviour traits and the consumption of food and beverage in children aged 3 to 6 years, based on data from the CORAL study. METHODS: Data were obtained from the Spanish CORAL study, a 10-year longitudinal cohort including 1407 participants (699 boys, 708 girls; 4.8 +/- 1.0 years). Eating behaviours were assessed using the Child Eating Behaviour Questionnaire (CEBQ) and dietary intake was measured using a validated COME-Kids Food and Beverage Frequency Questionnaire. Principal Component Analysis (PCA) was applied to identify dietary patterns. Associations were analysed with multivariable linear regression adjusted for covariates. RESULTS: In both sexes, higher Enjoyment of Food scores were associated with greater consumption of fish, fruits, vegetables, pulses, whole grains, and lower consumption of sweets. In contrast, higher Food Fussiness scores were associated with lower consumption of fruits, vegetables, fish, and pulses, and higher intake of sweets. PCA revealed five dietary patterns per sex, explaining 36.62% of the variance in boys and 36.07% in girls. Enjoyment of Food and Food Fussiness were the traits most strongly associated with distinct dietary patterns (p < 0.001). CONCLUSION: Eating behaviour traits are clearly associated with diet quality in early childhood. Enjoyment of Food supports healthier eating, while Food Fussiness may compromise it. These findings may inform early prevention strategies to encourage healthy eating habits and reduce the risk of childhood overweight and obesity. CI - (c) 2026. The Author(s). FAU - Maneschy, Ivie AU - Maneschy I AD - Growth, Exercise, NUtrition and Development (GENUD-B34_23R) Research Group. Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza and Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. FAU - Ortega-Ramirez, Ana Daniela AU - Ortega-Ramirez AD AD - Faculty of Medicine, University of Colima, Av. Universidad 33 Colonia Las Viboras, 28010, Colima, CP, Mexico. FAU - Jimeno-Martinez, Andrea AU - Jimeno-Martinez A AD - Growth, Exercise, NUtrition and Development (GENUD-B34_23R) Research Group. Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza and Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. FAU - Gil-Campos, Mercedes AU - Gil-Campos M AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. AD - Metabolism and Investigation Unit, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004, Cordoba, Spain. FAU - Leis, Rosaura AU - Leis R AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. AD - Unit of Pediatric Gastroenterology, Hepatology and Nutrition-Pediatrics Service. Hospital, Clinico Universitario de Santiago, Santiago de Compostela, Spain. AD - Pediatrics Nutrition Research Group-Health Research Institute of Santiago (IDIS)-ISCIII, Unit of Investigation in Nutrition, Growth and Human Development of Galicia (GALINUT), University of Santiago de Compostela, Santiago de Compostela, Spain. FAU - Babio, Nancy AU - Babio N AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. AD - Grup ANUT-DSM, Departament de Bioquimica i Biotecnologia, Universitat Rovira i Virgili, Unitat de Nutricio Humana, Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. FAU - Navas-Carretero, Santiago AU - Navas-Carretero S AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. AD - Department of Nutrition Food Science & Physiology, University of Navarra, 31008, Pamplona, Spain. AD - Center for Nutrition Research, University of Navarra, 31008, Pamplona, Spain. AD - IdisNA, Navarra Institute for Health Research, Pamplona, Spain. FAU - Pastor-Villaescusa, Belen AU - Pastor-Villaescusa B AD - Metabolism and Investigation Unit, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004, Cordoba, Spain. AD - Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS, RD21/0012/0008); Spanish Network in Maternal, Neonatal, Child and Developmental Health Research (RICORS-SAMID, RD24/0013/0007), Instituto de Salud Carlos III, Madrid, Spain. FAU - Vazquez-Cobela, Rocio AU - Vazquez-Cobela R AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. AD - Unit of Pediatric Gastroenterology, Hepatology and Nutrition-Pediatrics Service. Hospital, Clinico Universitario de Santiago, Santiago de Compostela, Spain. AD - Pediatrics Nutrition Research Group-Health Research Institute of Santiago (IDIS)-ISCIII, Unit of Investigation in Nutrition, Growth and Human Development of Galicia (GALINUT), University of Santiago de Compostela, Santiago de Compostela, Spain. FAU - Salas-Salvado, Jordi AU - Salas-Salvado J AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. AD - Grup ANUT-DSM, Departament de Bioquimica i Biotecnologia, Universitat Rovira i Virgili, Unitat de Nutricio Humana, Reus, Spain. AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. FAU - De Miguel-Etayo, Pilar AU - De Miguel-Etayo P AD - Growth, Exercise, NUtrition and Development (GENUD-B34_23R) Research Group. Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza and Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. pilardm@unizar.es. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. pilardm@unizar.es. FAU - Martinez, Jose Alfredo AU - Martinez JA AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. AD - Department of Nutrition Food Science & Physiology, University of Navarra, 31008, Pamplona, Spain. AD - Center for Nutrition Research, University of Navarra, 31008, Pamplona, Spain. AD - Precision Nutrition and Cardiometabolic Health Program, IMDEA-Food Institute (Madrid Institute for Advanced Studies), CEI UAM + CSIC, Madrid, Spain. AD - INstittute of Endocrinology and Nutrition, University of Valladolid, Valladolid, Spain. FAU - Llorente-Cantarero, Francisco Jesus AU - Llorente-Cantarero FJ AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. AD - Metabolism and Investigation Unit, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004, Cordoba, Spain. FAU - Picans-Leis, Rosaura AU - Picans-Leis R AD - Servicio de Neonatologia, Instituto de Investigacion Sanitaria de Santiago (IDIS), Hospital Clinico Universitario de Santiago, Santiago de Compostela, Espana. FAU - Pallas, Natalia Ferre AU - Pallas NF AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. AD - Pediatrics, Nutrition and Development Research Unit (PediNuR), Universitat Rovira i Virgili, Reus, Spain. FAU - Ruperez, Azahara I AU - Ruperez AI AD - Growth, Exercise, NUtrition and Development (GENUD-B34_23R) Research Group. Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza and Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. FAU - Jurado-Castro, Jose Manuel AU - Jurado-Castro JM AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. AD - Metabolism and Investigation Unit, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004, Cordoba, Spain. FAU - de la Torre-Aguilar, Maria Jose AU - de la Torre-Aguilar MJ AD - Metabolism and Investigation Unit, Maimonides Institute of Biomedicine Research of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004, Cordoba, Spain. FAU - Gheorghita, Irina AU - Gheorghita I AD - Institut d'Investigacio Sanitaria Pere Virgili (IISPV), Reus, Spain. AD - Pediatrics, Nutrition and Development Research Unit (PediNuR), Universitat Rovira i Virgili, Reus, Spain. FAU - Moreno, Luis A AU - Moreno LA AD - Growth, Exercise, NUtrition and Development (GENUD-B34_23R) Research Group. Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza and Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. FAU - Miguel-Berges, Maria L AU - Miguel-Berges ML AD - Growth, Exercise, NUtrition and Development (GENUD-B34_23R) Research Group. Instituto Agroalimentario de Aragon (IA2), Universidad de Zaragoza and Instituto de Investigacion Sanitaria de Aragon (IIS Aragon), Zaragoza, Spain. AD - Centro de Investigacion Biomedica en Red de Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III, Madrid, Spain. LA - eng PT - Journal Article DEP - 20260116 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 SB - IM MH - Humans MH - Female MH - Male MH - *Feeding Behavior/psychology MH - Child MH - Child, Preschool MH - Longitudinal Studies MH - *Diet/statistics & numerical data/methods MH - *Beverages/statistics & numerical data MH - Spain MH - Surveys and Questionnaires MH - Principal Component Analysis MH - Cohort Studies MH - Food Fussiness MH - *Child Behavior PMC - PMC12811333 OTO - NOTNLM OT - Child OT - Dietary intake OT - Eating behaviours OT - Foods consumption and beverages consumption COIS- Declarations. Conflicts of interest: The authors declare that they have no competing interests. EDAT- 2026/01/16 15:05 MHDA- 2026/01/16 15:06 PMCR- 2026/01/16 CRDT- 2026/01/16 11:05 PHST- 2025/02/26 00:00 [received] PHST- 2025/11/13 00:00 [accepted] PHST- 2026/01/16 15:06 [medline] PHST- 2026/01/16 15:05 [pubmed] PHST- 2026/01/16 11:05 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - 10.1007/s00394-025-03848-x [pii] AID - 3848 [pii] AID - 10.1007/s00394-025-03848-x [doi] PST - epublish SO - Eur J Nutr. 2026 Jan 16;65(1):26. doi: 10.1007/s00394-025-03848-x. PMID- 41543554 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260920 IS - 1436-6215 (Electronic) IS - 1436-6207 (Print) IS - 1436-6207 (Linking) VI - 65 IP - 1 DP - 2026 Jan 16 TI - Do 6-9-year-old children in Denmark adhere to national dietary recommendations and are there sociodemographic disparities? The Generation Healthy Kids study. PG - 24 LID - 10.1007/s00394-025-03863-y [doi] LID - 24 AB - PURPOSE: Diet in childhood is important for growth, brain development, and long-term health. Thus, assessing children's adherence to dietary recommendations and identifying sociodemographic groups with low adherence is of great public health relevance. We investigated dietary intake, adherence to recommendations, and sociodemographic differences in a large cohort of Danish children. METHODS: We analyzed baseline data from 1094 children aged 6-9 years from 23 schools across Denmark participating in the Generation Healthy Kids study. Diet was assessed by three-day dietary records and food frequency questionnaires for fish and supplements, focusing on key food groups, macronutrients, and iron. Fasting blood samples were collected from n = 347 and analyzed for nutritional biomarkers of fish, wholegrains, and iron for validation. RESULTS: Overall adherence to dietary recommendations showed a mean +/- SD score of 4.6 +/- 1.0 out of 7.0. However, < 15% adhered to the recommendations for fruit + vegetables, fish, and meat, and < 33% to recommendations for saturated fat (SFA) and iron. Adherence decreased with age and shorter parental education, due to lower intakes of fruit + vegetables and dairy with age, and lower wholegrain and higher meat intake with shorter parental education. Also, rural children had lower adherence and consumed less fruit + vegetables and more added sugar and SFA than urban. Non-Danish descendants consumed less wholegrains and sugar than Danish, and weight status was not associated with adherence. CONCLUSIONS: Danish children had relatively good dietary adherence, but intakes of fruit + vegetables, fish, meat, SFA, and iron remain a concern. Attention should be given to children of older age, short parental education, and rural backgrounds. FAU - Holmegaard, Frederik AU - Holmegaard F AD - Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark. fhj@nexs.ku.dk. FAU - Eilersen, Anna Gro AU - Eilersen AG AD - Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark. FAU - Lauritzen, Lotte AU - Lauritzen L AD - Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark. FAU - Molgaard, Christian AU - Molgaard C AD - Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark. FAU - Liu, Ming Rong AU - Liu MR AD - Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada. FAU - Stark, Ken D AU - Stark KD AD - Department of Kinesiology and Health Sciences, University of Waterloo, Waterloo, ON, Canada. FAU - Landberg, Rikard AU - Landberg R AD - Department of Life Sciences, Chalmers University of Technology, Gothenburg, Sweden. FAU - Krolner, Rikke Fredenslund AU - Krolner RF AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. FAU - Toft, Ulla AU - Toft U AD - Department of Prevention, Health Promotion and Community Care, Steno Diabetes Center Copenhagen, Herlev, Denmark. FAU - Damsgaard, Camilla Trab AU - Damsgaard CT AD - Department of Nutrition, Exercise and Sports, Faculty of Science, University of Copenhagen, Frederiksberg, Denmark. LA - eng PT - Journal Article DEP - 20260116 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 SB - IM MH - Humans MH - Child MH - Denmark MH - Female MH - Male MH - *Diet/statistics & numerical data/methods MH - Socioeconomic Factors MH - *Nutrition Policy MH - Diet Records MH - *Recommended Dietary Allowances MH - Socioeconomic Disparities in Health MH - *Patient Compliance/statistics & numerical data MH - Cohort Studies MH - Fruit MH - Vegetables MH - Sociodemographic Factors MH - Diet Surveys MH - Child Nutritional Physiological Phenomena PMC - PMC12811282 OTO - NOTNLM OT - Children's dietary intake OT - Dietary recommendations OT - Public health OT - Sociodemographic disparities COIS- Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: The study was approved by the Ethics Committee of Southern Denmark (S-20220094). Consent to participate: All children received oral information, and custody holders received both written and oral information about the study before custody holders gave written informed consent for their child to participate. EDAT- 2026/01/16 15:04 MHDA- 2026/06/27 00:53 PMCR- 2026/01/16 CRDT- 2026/01/16 11:03 PHST- 2025/09/29 00:00 [received] PHST- 2025/12/03 00:00 [accepted] PHST- 2026/06/27 00:53 [medline] PHST- 2026/01/16 15:04 [pubmed] PHST- 2026/01/16 11:03 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - 10.1007/s00394-025-03863-y [pii] AID - 3863 [pii] AID - 10.1007/s00394-025-03863-y [doi] PST - epublish SO - Eur J Nutr. 2026 Jan 16;65(1):24. doi: 10.1007/s00394-025-03863-y. PMID- 41543512 OWN - NLM STAT- MEDLINE DCOM- 20260116 LR - 20260626 IS - 2047-2986 (Electronic) IS - 2047-2978 (Print) IS - 2047-2978 (Linking) VI - 16 DP - 2026 Jan 16 TI - Development and external validation of an interpretable machine learning-based model for obesity risk prediction in 2-18-year-old children and adolescents in Beijing and Tangshan. PG - 04031 LID - 10.7189/jogh.16.04031 [doi] LID - 04031 AB - BACKGROUND: The multifactorial mechanisms driving childhood obesity, a global public health challenge, are yet to be fully elucidated. We aimed to develop and externally validate three widely applied machine learning models alongside logistic regression in 2-18-year-old children and adolescents in Beijing and Tangshan to predict obesity risk. As a further step, we wanted to interpret the optimised model and translate it into a web-based tool to inform clinical decision-making. METHODS: We analysed data of 19 024 (training/testing) and 2410 (external validation) children and adolescents from Beijing and Tangshan, respectively. Using a set of factors including demographic, familial, socioeconomic, lifestyle, and perinatal variables, we developed four models (light gradient boosting machine, random forest, eXtreme gradient boosting (XGBoost), and logistic regression) and compared their predictive performance. After validation, we selected an optimised model and interpreted it using SHapley Additive exPlanations (SHAP) analysis. Then, we developed an online calculator with interpretable visualisations to enable real-time risk assessment. RESULTS: The XGBoost model exhibited superior performance, with an area under the receiver operating characteristic curve (AUROC) of 0.875 on the external validation set, significantly outperforming the logistic regression model (AUROC = 0.718). To identify the minimal feature subset that maintained model efficacy, we incrementally incorporated predictors in the descending order of SHAP importance values while assessing key performance metrics (accuracy, AUROC, and F-beta score). This SHAP-based analysis identified nine key predictors of childhood obesity: birth length, paternal body mass index (BMI), maternal BMI, sleep duration, physical activity, birth weight, maternal age at delivery, delivery mode, and gestational age. The deployed online tool provides individualised risk probabilities and SHAP-derived explanations. CONCLUSIONS: The XGBoost model in our study was the superior ensemble learning method for predicting childhood obesity. The digital tool integrates this model and can help clinical practitioners determine individuals' risk of childhood obesity. CI - Copyright (c) 2026 by the Journal of Global Health. All rights reserved. FAU - Xue, Mei AU - Xue M AD - Graduate School, Beijing University of Chinese Medicine, Beijing, China. AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. FAU - Liu, Shufang AU - Liu S AD - Department of Pediatrics, China-Japan Friendship Hospital, Beijing, China. FAU - Zhang, Xiaoqian AU - Zhang X AD - Department of Traditional Chinese Medicine, Beijing Children's Hospital, Capital Medicine University, National Center for Children's Health, Beijing, China. FAU - Zhang, Zhixin AU - Zhang Z AD - Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing, China. FAU - Niu, Wenquan AU - Niu W AD - Center for Evidence-Based Medicine, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20260116 PL - Scotland TA - J Glob Health JT - Journal of global health JID - 101578780 SB - IM MH - Humans MH - Adolescent MH - Female MH - Risk Assessment/methods MH - Predictive Learning Models MH - China/epidemiology MH - Child, Preschool MH - Child MH - Beijing/epidemiology MH - Male MH - *Pediatric Obesity/epidemiology MH - Boosting Machine Learning Algorithms MH - *Machine Learning MH - Logistic Models MH - Random Forest MH - Risk Factors MH - Prediction Algorithms PMC - PMC12810588 COIS- Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests. EDAT- 2026/01/16 15:03 MHDA- 2026/01/16 15:04 PMCR- 2026/01/16 CRDT- 2026/01/16 10:52 PHST- 2026/01/16 15:04 [medline] PHST- 2026/01/16 15:03 [pubmed] PHST- 2026/01/16 10:52 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - jogh-16-04031 [pii] AID - 10.7189/jogh.16.04031 [doi] PST - epublish SO - J Glob Health. 2026 Jan 16;16:04031. doi: 10.7189/jogh.16.04031. PMID- 41543409 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 0974-5181 (Electronic) IS - 0971-9784 (Print) IS - 0971-9784 (Linking) VI - 29 IP - 1 DP - 2026 Jan 1 TI - Predicting Reintubation in Postoperative Pediatric Cardiac Surgery: A Machine Learning Approach. PG - 72-80 LID - 10.4103/aca.aca_62_25 [doi] AB - BACKGROUND: Accurate prediction of reintubation in pediatric patients following cardiac surgery is vital for enhancing postoperative care. This study aimed to identify key predictors of reintubation and train a multilayer perceptron (MLP) neural network model for prediction. METHODS: This retrospective analysis included clinical data from 294 pediatric patients (1-24 months of age) who underwent cardiac surgery and postoperative mechanical ventilation between January and December 2024. Patients who were successfully extubated and monitored for reintubation were included. Significant predictors were identified using Pearson Chi-square (PC(2)) test and binomial logistic regression analysis (BLRA). An MLP neural network was trained using clinical covariates to predict reintubation. RESULTS: Significant predictors of reintubation included low BMI (0.1-1 percentile, P < 0.01, PC(2)), emergency surgery (P < 0.01, PC(2)), previous infection (P < 0.01, PC(2)), pre-reintubation ABG levels (P < 0.001, PC(2)), and procedure type (aortoplasty, P = 0.05, PC(2)). Additionally, the duration of ventilation (P = 0.014, BLRA) and the RACHS2 score (P = 0.006, BLRA) were significant predictors. The MLP model achieved a sensitivity of 93.7% and a specificity of 90.5%, with an F1-score of 0.94. The sum of squared error was 0.152, the root mean squared error was 0.248, and the area under the receiver operating characteristic curve was 0.94 for both training and testing datasets. CONCLUSION: The MLP neural network exhibited excellent predictive accuracy for identifying risk factors associated with reintubation. CI - Copyright (c) 2026 Annals of Cardiac Anaesthesia. FAU - Harish, Sumedha AU - Harish S AD - Department of Cardiac Anaesthesia, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Karnataka, India. FAU - Prasannasimha, Parimala AU - Prasannasimha P AD - Department of Cardiac Anaesthesia, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Karnataka, India. FAU - Prabhakar, V AU - Prabhakar V AD - Department of Cardiac Anaesthesia, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Karnataka, India. FAU - Singh, Naveen G AU - Singh NG AD - Department of Cardiac Anaesthesia, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Karnataka, India. FAU - Lakshmi, S AU - Lakshmi S AD - Department of Cardiac Anaesthesia, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Karnataka, India. FAU - Rao, Karthik N AU - Rao KN AD - Department of Head and Neck Oncology, Sri Shankara Cancer Foundation, Bangalore, Karnataka, India. LA - eng PT - Journal Article DEP - 20260116 PL - India TA - Ann Card Anaesth JT - Annals of cardiac anaesthesia JID - 9815987 SB - IM MH - Humans MH - *Cardiac Surgical Procedures/methods MH - Retrospective Studies MH - Infant MH - Female MH - *Machine Learning MH - Male MH - *Intubation, Intratracheal/statistics & numerical data/methods MH - Child, Preschool MH - Predictive Learning Models MH - Multilayer Perceptrons MH - *Postoperative Care/methods MH - Respiration, Artificial MH - Neural Networks, Computer MH - Postoperative Complications MH - Prediction Algorithms PMC - PMC12935110 OTO - NOTNLM OT - Anesthesia OT - artificial intelligence OT - pediatric cardiac surgery OT - predictive modelling OT - reintubation COIS- SH and KNR are married EDAT- 2026/01/16 15:04 MHDA- 2026/01/16 15:05 PMCR- 2026/01/01 CRDT- 2026/01/16 10:05 PHST- 2025/03/16 00:00 [received] PHST- 2025/07/15 00:00 [accepted] PHST- 2026/01/16 15:05 [medline] PHST- 2026/01/16 15:04 [pubmed] PHST- 2026/01/16 10:05 [entrez] PHST- 2026/01/01 00:00 [pmc-release] AID - 00660469-202601000-00010 [pii] AID - ACA-29-72 [pii] AID - 10.4103/aca.aca_62_25 [doi] PST - ppublish SO - Ann Card Anaesth. 2026 Jan 1;29(1):72-80. doi: 10.4103/aca.aca_62_25. Epub 2026 Jan 16. PMID- 41543142 OWN - NLM STAT- MEDLINE DCOM- 20260829 LR - 20260831 IS - 1523-4681 (Electronic) IS - 0884-0431 (Print) IS - 0884-0431 (Linking) VI - 41 IP - 9 DP - 2026 Aug 21 TI - A novel model to study the impact of gender-affirming therapy on bone in young male mice. PG - 1027-1038 LID - 10.1093/jbmr/zjag009 [doi] AB - Transgender individuals are increasingly seeking gender-affirming therapy. For children and adolescents, this typically involves puberty suppression followed by hormone treatment. However, potential long-term adverse effects on the growing skeleton remain poorly characterized, largely due to the lack of appropriate preclinical animal models. Existing models often rely on surgical puberty suppression and, in the case of estradiol (E2) administration, cause a high bone mass-phenotype that is not observed in the clinical setting. To address this, we developed a novel preclinical mouse model that mimics the medical approach used in transgirls and analyzed the effects of gender-affirming therapy on bone. Four-week-old male mice were treated with the gonadotropin-releasing hormone analogue degarelix (DGX) for pharmacological puberty suppression. After 4 wk, E2 was administered at different doses, and bone properties were analyzed after an additional 8 wk. DGX treatment effectively suppressed sex steroid signaling, leading to reduced bone mass and strength, which were dose-dependently restored by E2. While high E2 doses resulted in an excessive increase in bone mass, thereby precluding further mechanistic study, lower doses resulted in a bone phenotype resembling that of native females. At the cellular level, DGX-mediated puberty suppression resulted in increased bone resorption that exceeded bone formation, and also caused an accumulation of marrow adipocytes. Subsequent low-dose E2 administration reduced bone resorption, stimulated bone formation, and prevented the increase in bone marrow adiposity. In summary, we established and validated a mouse model that accurately mimics gender-affirming therapy initiated during early puberty and enables the study of its effects on bone. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research. FAU - Verlinden, Lieve AU - Verlinden L AD - Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, 3000 Leuven, Belgium. FAU - Calvo Blanco, Sandra AU - Calvo Blanco S AD - Basic and Translational Endocrinology (BaTE), Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium. FAU - Liekens, Toke AU - Liekens T AD - Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, 3000 Leuven, Belgium. FAU - Stockmans, Ingrid AU - Stockmans I AD - Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, 3000 Leuven, Belgium. FAU - Moermans, Karen AU - Moermans K AD - Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, 3000 Leuven, Belgium. FAU - Schollaert, Dieter AU - Schollaert D AD - Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, 3000 Leuven, Belgium. FAU - Vercruysse, Chris AU - Vercruysse C AD - Clinical Tissue and Cell Culture Core, Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium. FAU - Fiers, Tom AU - Fiers T AD - Department of Clinical Biology, Ghent University Hospital, 9000 Ghent, Belgium. FAU - Reyns, Tim AU - Reyns T AD - Department of Clinical Biology, Ghent University Hospital, 9000 Ghent, Belgium. FAU - Narinx, Nick AU - Narinx N AUID- ORCID: 0000-0002-7342-8724 AD - Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, 3000 Leuven, Belgium. AD - Department of Laboratory Medicine, UZ Leuven, 3000 Leuven, Belgium. FAU - De Waal, Tom AU - De Waal T AD - Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, 3000 Leuven, Belgium. AD - Department of Laboratory Medicine, UZ Leuven, 3000 Leuven, Belgium. FAU - Antonio, Leen AU - Antonio L AUID- ORCID: 0000-0002-1079-2860 AD - Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, 3000 Leuven, Belgium. FAU - Dmitriev, Ruslan I AU - Dmitriev RI AD - Tissue Engineering and Biomaterials Group, Department of Human Structure and Repair, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium. FAU - Claessens, Frank AU - Claessens F AUID- ORCID: 0000-0002-8676-7709 AD - Molecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, 3000 Leuven, Belgium. FAU - Vanderschueren, Dirk AU - Vanderschueren D AD - Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, 3000 Leuven, Belgium. FAU - Carmeliet, Geert AU - Carmeliet G AUID- ORCID: 0000-0001-8324-4462 AD - Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, 3000 Leuven, Belgium. FAU - Dubois, Vanessa AU - Dubois V AUID- ORCID: 0000-0001-8894-2980 AD - Basic and Translational Endocrinology (BaTE), Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium. FAU - Stegen, Steve AU - Stegen S AUID- ORCID: 0000-0002-4471-6401 AD - Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism (CHROMETA), KU Leuven, 3000 Leuven, Belgium. LA - eng GR - STG/22/034/KU Leuven/ GR - BOF/STA/202109/045/Special Research Fund starting grant of Ghent University/ GR - FWO #G052624N/Research Foundation-Flanders/ PT - Journal Article PL - England TA - J Bone Miner Res JT - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JID - 8610640 RN - 4TI98Z838E (Estradiol) RN - 0 (Puberty Inhibitors) SB - IM MH - Animals MH - Male MH - Mice MH - *Bone and Bones/drug effects/pathology MH - Estradiol/pharmacology MH - Puberty Suppression MH - Female MH - Puberty Inhibitors MH - *Gender-Affirming Procedures MH - Disease Models, Animal PMC - PMC13525205 OAB - As more transgender youth seek gender-affirming care, it is crucial to understand how these medical interventions affect long-term health. This is especially true for the skeleton, which is still growing during adolescence and therefore very likely to respond to the introduced hormonal fluctuations. In young transgirls, treatment typically starts with medication to suppress puberty, followed by estrogen administration to align with their gender identity. However, how these interventions affect bone properties is not fully understood, especially on the long run. To explore this at a mechanistic level, we developed a mouse model that closely mimics the timing and effects of gender-affirming treatments used in transgirls. We found that puberty suppression led to decreased bone mass and strength, which was related to changes in bone-forming osteoblasts and bone-resorbing osteoclasts, together with increased fat content in the bone marrow. Subsequent estrogen administration dose-dependently reversed these effects, with lower doses restoring skeletal parameters without causing abnormally high bone mass, while higher doses led to very dense bone which does not align with clinical observations. Collectively, our work established a useful model to study how gender-affirming treatments influence growing bones and offers insights that eventually guide future clinical care in transgender adolescents. OABL- eng OTO - NOTNLM OT - bone OT - estrogen OT - gender-affirming therapy OT - puberty suppression OT - transgender COIS- The authors have nothing to disclose. EDAT- 2026/01/16 15:03 MHDA- 2026/08/29 12:02 PMCR- 2026/01/16 CRDT- 2026/01/16 08:14 PHST- 2025/10/07 00:00 [received] PHST- 2025/12/23 00:00 [revised] PHST- 2026/01/11 00:00 [accepted] PHST- 2026/08/29 12:02 [medline] PHST- 2026/01/16 15:03 [pubmed] PHST- 2026/01/16 08:14 [entrez] PHST- 2026/01/16 00:00 [pmc-release] AID - 8427239 [pii] AID - zjag009 [pii] AID - 10.1093/jbmr/zjag009 [doi] PST - ppublish SO - J Bone Miner Res. 2026 Aug 21;41(9):1027-1038. doi: 10.1093/jbmr/zjag009. PMID- 41542793 OWN - NLM STAT- MEDLINE DCOM- 20260610 LR - 20260626 IS - 1522-2586 (Electronic) IS - 1053-1807 (Linking) VI - 63 IP - 5 DP - 2026 May TI - Assessment of Myocardial Microvascular Function in Athletes Using Resting Cardiac Magnetic Resonance First-Pass Perfusion. PG - 1348-1362 LID - 10.1002/jmri.70235 [doi] AB - BACKGROUND: Impaired myocardial microvascular function may promote cardiac remodeling (CR) and myocardial fibrosis (MF), increasing cardiovascular risks in athletes. Early assessment of myocardial microcirculatory perfusion presents potential for improving athlete care. PURPOSE: To evaluate the characteristics of myocardial microvascular function in athletes using resting cardiac MRI first-pass perfusion. STUDY TYPE: Prospective. POPULATION: One hundred and eighty-six athletes (median age 24 years, range 18-57; 167 males; mean 10 h/week exercise for 5 years) and 43 controls (median age 25 years, range 21-56; 35 males; < 3 h/week exercise). FIELD STRENGTH/SEQUENCE: Balanced steady-state free precession, gradient echo sequence, and phase sensitive inversion recovery late gadolinium enhancement sequences at 3.0 T. ASSESSMENT: CR was defined as any cardiac parameters exceeding the 99th percentile upper reference limits. MF was visually evaluated by three independent radiologists. Left ventricular resting first-pass perfusion parameters were assessed and compared across different groups. A predictive model was developed to screen athletes with and without CR/MF. STATISTICAL TESTS: Univariate analysis and Pearson coefficient were used. Area under the receiver operating characteristic curve (AUC) was used to assess the performance of the predictive model. A p < 0.05 was considered significant. RESULTS: Athletes exhibited lower upslope (2.12 [1.72; 2.56] vs. 2.77 [1.94; 3.22]) and maximum signal intensity (MaxSI) (20.8 [18.3; 23.6] vs. 29.5 [26.8; 33.0]), longer time to maximum signal intensity (TTM) (35.1 [31.0; 47.7] vs. 29.5 [26.8; 33.0] s) than controls. Male athletes with CR and/or MF showed lower upslope (1.54 [1.29; 1.96] vs. 1.94 [1.62; 2.43]) and MaxSI (18.0 [15.5; 21.7] vs. 21.2 [19.0; 23.5]), higher TTM (40.3 [31.5; 53.9] vs. 34.5 [29.0; 44.0] s) than those without. These perfusion parameters of athletes showed a negative correlation with global T2 mapping, QRS and corrected QT interval (r = -0.210 to -0.292). The AUC for the prediction model of CR and/or MF was 0.837. DATA CONCLUSION: Athletes showed lower resting myocardial perfusion than controls, especially in those with CR and/or MF, suggesting an association between perfusion reduction and CR/MF. EVIDENCE LEVEL: 1. TECHNICAL EFFICACY: Stage 2. CI - (c) 2026 International Society for Magnetic Resonance in Medicine. FAU - Liu, Qian AU - Liu Q AD - Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. FAU - Li, Cao AU - Li C AD - Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. FAU - Qi, Wan-Yin AU - Qi WY AD - Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. FAU - Tang, Min AU - Tang M AD - Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. FAU - Luo, Yong AU - Luo Y AD - Department of Cardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. FAU - Zhang, Xiao-Yong AU - Zhang XY AD - Clinical Science, Philips Healthcare, Chengdu, Sichuan, China. FAU - Zhong, Liang AU - Zhong L AD - National Heart Centre Singapore, Singapore, Singapore. FAU - Chen, Jing AU - Chen J AUID- ORCID: 0000-0002-7200-4081 AD - Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China. LA - eng GR - 2024NSFSC1793/Sichuan Science and Technology program/ PT - Journal Article DEP - 20260116 PL - United States TA - J Magn Reson Imaging JT - Journal of magnetic resonance imaging : JMRI JID - 9105850 RN - 0 (Contrast Media) SB - IM MH - Humans MH - Male MH - Adult MH - Prospective Studies MH - *Microcirculation MH - *Athletes MH - *Magnetic Resonance Imaging MH - Female MH - Middle Aged MH - Adolescent MH - Young Adult MH - *Heart/diagnostic imaging MH - Coronary Circulation MH - Perfusion Magnetic Resonance Imaging MH - Myocardium/pathology MH - Rest MH - Contrast Media MH - *Microvessels/diagnostic imaging MH - ROC Curve OAB - Athlete cardiovascular health has attracted widespread attention; however, research on the myocardial microcirculatory perfusion remains limited. This study used 3.0 T cardiac MRI first-pass perfusion imaging to assess resting myocardial microcirculatory perfusion in athletes (n = 186) and compare it with sedentary healthy controls (n = 43). It found athletes had lower resting myocardial perfusion than controls, especially those with cardiac remodeling (CR) and/or myocardial fibrosis (MF), indicating an association between reduced perfusion and the aforementioned pathological conditions. The upslope values of mid-ventricular segments may serve as potential markers for predicting CR or MF. OABL- eng OTO - NOTNLM OT - cardiac magnetic resonance OT - cardiac remodeling OT - exercise OT - first-pass perfusion OT - myocardial fibrosis OT - myocardial microvascular function EDAT- 2026/01/16 15:05 MHDA- 2026/04/10 06:32 CRDT- 2026/01/16 06:13 PHST- 2025/12/25 00:00 [revised] PHST- 2025/08/07 00:00 [received] PHST- 2025/12/29 00:00 [accepted] PHST- 2026/04/10 06:32 [medline] PHST- 2026/01/16 15:05 [pubmed] PHST- 2026/01/16 06:13 [entrez] AID - 10.1002/jmri.70235 [doi] PST - ppublish SO - J Magn Reson Imaging. 2026 May;63(5):1348-1362. doi: 10.1002/jmri.70235. Epub 2026 Jan 16. PMID- 41539531 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260803 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 220 DP - 2026 May 1 TI - Contribution of parental feeding practices and home environmental factors to the eating behaviours of preschool children. PG - 108461 LID - S0195-6663(26)00022-X [pii] LID - 10.1016/j.appet.2026.108461 [doi] AB - From family and ecological systems perspectives, parental feeding styles at the dyadic level play a proximal role in shaping young children's eating behaviours. However, far less is known about how broader family-level factors contribute to these behaviours. This cross-sectional study investigated the contribution of parental feeding styles and home environmental factors to the eating behaviours of preschool children. A total of 253 parent-child dyads were recruited from 16 kindergartens in Hong Kong, China. Parents completed validated questionnaires, namely the Parental Feeding Style Questionnaire and the Children's Eating Behaviour Questionnaire, which assessed feeding styles (instrumental, emotional, encouragement to eat, and control over eating), the home environmental factors (mealtime structure, mealtime distractions, and household chaos), and children's appetite-trait eating behaviours. Hierarchical multiple regression analyses, controlling for demographic variables, were conducted. Parental feeding styles explained 3-12 % of the variance in children's eating behaviours. Notably, control over eating was associated with lower emotional overeating and reduced food fussiness, as well as with lower satiety responsiveness (i.e., greater appetite). Adding home environmental factors explained an additional 15 % of the variance beyond feeding styles, with significant incremental contributions observed for desire to drink, food responsiveness, and slowness in eating. These findings underscore that both proximal feeding styles and family-level home environmental factors uniquely and additively shape preschool children's eating behaviours. Interventions should therefore promote not only responsive and structured parental feeding styles but also structured mealtimes, reduced mealtime distractions, and a more organised household environment to support healthy eating in children. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Wan, Alison Wing Lam AU - Wan AWL AD - Centre for Child and Family Science, The Education University of Hong Kong, China. FAU - Chan, Derwin King Chung AU - Chan DKC AD - Department of Social Sciences, Hong Kong Metropolitan University, China. FAU - Chung, Kevin Kien Hoa AU - Chung KKH AD - Centre for Child and Family Science, The Education University of Hong Kong, China; Department of Early Childhood Education, The Education University of Hong Kong, China. Electronic address: kevin@eduhk.hk. LA - eng PT - Journal Article DEP - 20260113 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Child, Preschool MH - Female MH - Male MH - *Feeding Behavior/psychology MH - Cross-Sectional Studies MH - *Parenting/psychology MH - Hong Kong MH - *Child Behavior/psychology MH - Surveys and Questionnaires MH - *Home Environment MH - *Parent-Child Relations MH - Meals MH - Appetite MH - Parents/psychology MH - Emotional Eating MH - Food Fussiness OTO - NOTNLM OT - Appetitive traits OT - Early childhood OT - Feeding styles OT - Household chaos OT - Incremental contribution OT - Mealtime environment COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/16 17:21 MHDA- 2026/02/21 00:56 CRDT- 2026/01/15 19:22 PHST- 2025/10/30 00:00 [received] PHST- 2025/12/10 00:00 [revised] PHST- 2026/01/13 00:00 [accepted] PHST- 2026/02/21 00:56 [medline] PHST- 2026/01/16 17:21 [pubmed] PHST- 2026/01/15 19:22 [entrez] AID - S0195-6663(26)00022-X [pii] AID - 10.1016/j.appet.2026.108461 [doi] PST - ppublish SO - Appetite. 2026 May 1;220:108461. doi: 10.1016/j.appet.2026.108461. Epub 2026 Jan 13. PMID- 41539432 OWN - NLM STAT- MEDLINE DCOM- 20260323 LR - 20260626 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 72 DP - 2026 Apr TI - Comparing the eating attitudes test (EAT -26) and disorder examination questionnaire (EDE-Q) as screening tools for eating disorders among young adults: A population-specific analysis. PG - 102917 LID - S2405-4577(26)00012-4 [pii] LID - 10.1016/j.clnesp.2026.102917 [doi] AB - BACKGROUND AND AIMS: Eating disorders (EDs) are an emerging issue worldwide. The Eating Disorder Examination Questionnaire (EDE-Q) and the Eating Attitudes Test (EAT) are widely used research standards for evaluating EDs. This study aims to examine and determine the best ED scoring system, which tool demonstrates stronger associations for specific population subgroups, and the determinants for each scoring system in identifying EDs. METHODS: A total of 1267 young adults were enrolled in a cross-sectional study. Anthropometric and general characteristics were collected, and EDs were assessed using the EDE-Q and the EAT-26. Several inter-rater reliability indicators were computed, and a logistic regression model was employed to identify the determinants of EDs. RESULTS: Across both scoring systems, higher BMI categories were significantly related to a higher likelihood (OR) of disordered eating. Compared to the EAT-26, the EDE-Q found significantly more disordered behaviors, particularly among females and those who were overweight or obese. Moderate agreement (Po = 0.666; kappa = 0.281) and significant asymmetry (p < 0.001) were found between the two scales, suggesting that they capture distinct symptom patterns. BMI, female sex, and physical inactivity were significant predictors of disordered eating in multivariable analyses; the EAT-26 showed stronger correlations with physical inactivity, and the EDE-Q showed stronger associations with weight-related symptoms and female sex. CONCLUSION: The EAT-26 and EDE-Q captured different patterns of disordered eating, with the EDE-Q identifying more cases, especially among overweight and obese females. Agreement between tools was modest, and BMI, female sex, and physical inactivity were significant predictors of disordered-eating risk. These findings highlight the need to select screening tools based on population characteristics and symptom profiles. CI - Copyright (c) 2026 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved. FAU - Agraib, Lana M AU - Agraib LM AD - Department of Nutrition and Food Science, Faculty of Allied Medical Sciences, Al-Balqa Applied University, Al-Salt, Jordan. Electronic address: Lanamg2007@bau.edu.jo. FAU - Al-Shami, Islam AU - Al-Shami I AD - Department of Clinical Nutrition and Dietetics, Faculty of Applied Medical Sciences, Hashemite University, Zarqa, Jordan. Electronic address: islamk@hu.edu.jo. FAU - Alkhatib, Buthaina AU - Alkhatib B AD - Department of Clinical Nutrition and Dietetics, Faculty of Applied Medical Sciences, Hashemite University, Zarqa, Jordan. Electronic address: bkhatib@hu.edu.jo. FAU - Orabi, Aliaa AU - Orabi A AD - Department of Nutrition and Food Technology, Faculty of Agriculture, The University of Jordan, Amman, Jordan. Electronic address: aliaajorabi@gmail.com. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260113 PL - England TA - Clin Nutr ESPEN JT - Clinical nutrition ESPEN JID - 101654592 SB - IM MH - Humans MH - Female MH - *Feeding and Eating Disorders/diagnosis/epidemiology/psychology MH - Surveys and Questionnaires MH - Male MH - Cross-Sectional Studies MH - Young Adult MH - Body Mass Index MH - Reproducibility of Results MH - Adult MH - Obesity MH - Adolescent MH - *Feeding Behavior MH - Logistic Models MH - Mass Screening/methods OTO - NOTNLM OT - EAT-26 OT - EDE-Q OT - Eating disorders OT - Obesity OT - Physical inactivity OT - adults COIS- Declaration of competing interest The authors have no conflicts of interest to disclose. EDAT- 2026/01/16 17:21 MHDA- 2026/03/23 06:31 CRDT- 2026/01/15 19:16 PHST- 2025/09/27 00:00 [received] PHST- 2025/12/16 00:00 [revised] PHST- 2026/01/07 00:00 [accepted] PHST- 2026/03/23 06:31 [medline] PHST- 2026/01/16 17:21 [pubmed] PHST- 2026/01/15 19:16 [entrez] AID - S2405-4577(26)00012-4 [pii] AID - 10.1016/j.clnesp.2026.102917 [doi] PST - ppublish SO - Clin Nutr ESPEN. 2026 Apr;72:102917. doi: 10.1016/j.clnesp.2026.102917. Epub 2026 Jan 13. PMID- 41539167 OWN - NLM STAT- MEDLINE DCOM- 20260602 LR - 20260626 IS - 1873-1244 (Electronic) IS - 0899-9007 (Linking) VI - 144 DP - 2026 Apr TI - Adherence to the Mediterranean diet and depressive symptoms. A cross-sectional study among Italian university students: The UniFoodWaste study. PG - 113070 LID - S0899-9007(25)00387-9 [pii] LID - 10.1016/j.nut.2025.113070 [doi] AB - BACKGROUND: Depression is a major global health issue and is particularly prevalent among university students. Emerging evidence suggests that dietary patterns, especially the Mediterranean diet (MD), may influence mental health. This study aimed to examine the association between adherence to the MD and depressive symptoms among Italian university students. STUDY DESIGN: Cross-sectional study. METHODS: A cross-sectional, web-based survey was conducted among students aged >/=18 y enrolled at the University of Milan (N = 2697). Adherence to the MD was assessed using the validated Medi-Lite score (range 0-18), while depressive symptoms were measured with the Patient Health Questionnaire-9 (PHQ-9), analyzed both as a continuous variable and using established cut-offs (>/=5 and >/=10). Multivariable logistic and linear regression models were used to assess associations between MD adherence, individual dietary components, and depressive symptoms, adjusting for age and sex. RESULTS: Higher MD adherence was significantly associated with fewer depressive symptoms. Each one-point increase in the Medi-Lite score was linked to lower odds of PHQ-9 >/= 10 (aOR = 0.91, 95% confidence interval [CI]: 0.88-0.95; P = 0.001), PHQ-9 >/= 5 (aOR = 0.89, 95% CI: 0.85-0.93; P < 0.001), and reduced PHQ-9 scores (beta = -0.02, 95% CI: -0.03 to -0.01; P = 0.001). Consuming >2 portions/d of fruit (aOR = 0.60, 95% CI: 0.45-0.80; P = 0.001) and >2.5 portions/d of vegetables (aOR = 0.62, 95% CI: 0.45-0.85; P = 0.003) was associated with lower odds of depressive symptoms; vegetable intake also correlated with lower PHQ-9 scores (beta = -0.14, 95% CI: -0.23 to -0.06; P = 0.001). Reduced meat intake (<1 portion/d) and regular olive oil use were further linked to lower depressive symptomatology. In contrast, alcohol consumption of 1 to 2 units/d (aOR = 1.41, 95% CI: 1.10-1.79; P = 0.006) and frequent use of food waste apps (>/=1/wk: aOR = 4.26, 95% CI: 1.18-15.34; P = 0.027; beta = 0.38, 95% CI: 0.00-0.76; P = 0.049) were associated with increased depressive symptoms. CONCLUSIONS: Greater adherence to the MD was associated with lower depressive symptoms among university students. Promoting MD adherence in student health programs may offer a useful non-pharmacological strategy to support mental well-being. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Pennisi, Flavia AU - Pennisi F AD - Faculty of Medicine, University Vita-Salute San Raffaele, Milan, Italy; PhD National Program in One Health Approaches to Infectious Diseases and Life Science Research Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy. FAU - Nucci, Daniele AU - Nucci D AD - PhD National Program in One Health Approaches to Infectious Diseases and Life Science Research Department of Public Health, Experimental and Forensic Medicine, University of Pavia, Pavia, Italy; Dipartimento di Igiene e Prevenzione Sanitaria, Agenzia di Tutela della Salute (ATS) Brescia, Struttura Semplice Dipartimentale Igiene Alimenti e Nutrizione, Brescia, Italy. FAU - Pinto, Antonio AU - Pinto A AD - Faculty of Medicine, University Vita-Salute San Raffaele, Milan, Italy. Electronic address: pinto.antonio@hsr.it. FAU - Stacchini, Lorenzo AU - Stacchini L AD - Dipartimento Sanita Territoriale, USL Toscana Nord Ovest, Pisa, Italy. FAU - Veronese, Nicola AU - Veronese N AD - Saint Camillus International University of Health Sciences, Faculty of Medicine, Rome, Italy. FAU - Maggi, Stefania AU - Maggi S AD - Fondazione Dieta Mediterranea, Rome, Italy. FAU - Signorelli, Carlo AU - Signorelli C AD - Faculty of Medicine, University Vita-Salute San Raffaele, Milan, Italy. FAU - Baldo, Vincenzo AU - Baldo V AD - Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padua, Padova, Veneto, Italy. FAU - Gianfredi, Vincenza AU - Gianfredi V AD - Department of Cardiac Thoracic Vascular Sciences and Public Health, University of Padua, Padova, Veneto, Italy. LA - eng PT - Journal Article DEP - 20251219 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 SB - IM MH - Humans MH - *Diet, Mediterranean/statistics & numerical data/psychology MH - Cross-Sectional Studies MH - Female MH - *Depression/epidemiology/prevention & control MH - Male MH - Italy/epidemiology MH - *Students/statistics & numerical data/psychology MH - Universities MH - Young Adult MH - Adolescent MH - Adult MH - Surveys and Questionnaires MH - Feeding Behavior/psychology MH - *Patient Compliance/statistics & numerical data OTO - NOTNLM OT - Depressive symptoms OT - Mediterranean diet OT - Mental health OT - Nutritional epidemiology OT - University students COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships, which may be considered as potential competing interests: Vincenza Gianfredi reports financial support was provided by University of Milan. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this article. EDAT- 2026/01/16 17:21 MHDA- 2026/02/14 05:30 CRDT- 2026/01/15 18:15 PHST- 2025/09/16 00:00 [received] PHST- 2025/12/13 00:00 [revised] PHST- 2025/12/15 00:00 [accepted] PHST- 2026/02/14 05:30 [medline] PHST- 2026/01/16 17:21 [pubmed] PHST- 2026/01/15 18:15 [entrez] AID - S0899-9007(25)00387-9 [pii] AID - 10.1016/j.nut.2025.113070 [doi] PST - ppublish SO - Nutrition. 2026 Apr;144:113070. doi: 10.1016/j.nut.2025.113070. Epub 2025 Dec 19. PMID- 41537676 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1440-1754 (Electronic) IS - 1034-4810 (Print) IS - 1034-4810 (Linking) VI - 62 IP - 3 DP - 2026 Mar TI - Fat-Free Mass Predictions From Anthropometrics in South African Prepubertal Children. PG - 422-430 LID - 10.1111/jpc.70276 [doi] AB - BACKGROUND: South African children face a double burden of malnutrition from undernutrition and rising obesity. Simple, accurate methods to estimate fat-free mass, a key health indicator, are needed, as bioelectrical impedance analysis is limited by cost, availability and lack of local validation. OBJECTIVES: To develop and validate prediction equations for fat-free mass using simple anthropometric measurements in children aged 6-9 years. METHODS: In this cross-sectional study, anthropometric and bioelectrical impedance data were obtained from 117 children. Bioelectrical impedance-derived fat-free mass was used as reference in multivariable regression models. Four equations were externally validated in 75 Black prepubertal children, using dual-energy X-ray absorptiometry-derived fat-free mass as standard. Relationships, mean differences, and agreement were assessed using Pearson's correlation, independent t-tests and Bland-Altman plots, respectively. RESULTS: Fourteen prediction equations, containing five to nine variables, were developed (R (2) range: 0.88-0.92) in the sample of children (51% Black; 55% boys; 7.9 +/- 0.8 years). Four equations were strongly correlated with dual-energy X-ray absorptiometry-derived fat-free mass (r > 0.95; p < 0.001) in the validation sample (8.5 +/- 1.3 years), and three yielded estimates with acceptable agreement (mean difference: 0.16-0.94 kg; limit of agreement: +/-5 kg). CONCLUSION: Fat-free mass of prepubertal children can be predicted using simple anthropometric measurements, allowing assessment of body composition in low-resource settings. CI - (c) 2026 The Author(s). Journal of Paediatrics and Child Health published by John Wiley & Sons Australia, Ltd on behalf of Paediatrics and Child Health Division (The Royal Australasian College of Physicians). FAU - White, Zelda AU - White Z AUID- ORCID: 0000-0002-3428-1838 AD - Department Human Nutrition, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. FAU - Walsh, Lauren M AU - Walsh LM AD - Department Human Nutrition, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. FAU - Pretorius, Adeline AU - Pretorius A AUID- ORCID: 0000-0002-9761-0694 AD - Department of Consumer and Food Sciences, Faculty of Natural and Agricultural Sciences, University of Pretoria, Pretoria, South Africa. FAU - Wenhold, Friede A M AU - Wenhold FAM AD - Department Human Nutrition, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa. AD - Research Centre for Maternal, Fetal, Newborn & Child Health Care Strategies, University of Pretoria, Pretoria, South Africa. LA - eng GR - EA/055/19WG/AV/SOUTH AFRICAN SUGAR ASSOCIATION/ GR - Institute of Food, Nutrition and Wellbeing (IFNuW)/ PT - Journal Article DEP - 20260115 PL - Australia TA - J Paediatr Child Health JT - Journal of paediatrics and child health JID - 9005421 SB - IM MH - Humans MH - Child MH - Female MH - South Africa MH - Cross-Sectional Studies MH - Male MH - *Electric Impedance MH - *Anthropometry/methods MH - Absorptiometry, Photon MH - *Body Composition MH - Southern African People PMC - PMC12976190 OTO - NOTNLM OT - anthropometry OT - bioelectrical impedance analysis OT - body composition OT - children OT - dual energy X-ray absorptiometry OT - fat-free mass COIS- The authors declare no conflicts of interest. EDAT- 2026/01/16 17:21 MHDA- 2026/03/11 18:59 PMCR- 2026/03/11 CRDT- 2026/01/15 09:42 PHST- 2025/12/17 00:00 [revised] PHST- 2025/11/06 00:00 [received] PHST- 2025/12/19 00:00 [accepted] PHST- 2026/03/11 18:59 [medline] PHST- 2026/01/16 17:21 [pubmed] PHST- 2026/01/15 09:42 [entrez] PHST- 2026/03/11 00:00 [pmc-release] AID - JPC70276 [pii] AID - 10.1111/jpc.70276 [doi] PST - ppublish SO - J Paediatr Child Health. 2026 Mar;62(3):422-430. doi: 10.1111/jpc.70276. Epub 2026 Jan 15. PMID- 41538793 OWN - NLM STAT- MEDLINE DCOM- 20260115 LR - 20260202 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 28 DP - 2026 Jan 15 TI - Leisure Screen Time, Internet Gaming Disorder, and Mental Health Among Chinese Adolescents: Large-Scale Cross-Sectional Study. PG - e80737 LID - 10.2196/80737 [doi] LID - e80737 AB - BACKGROUND: Adolescence is a critical period for mental health vulnerability alongside rising digital media exposure. Current evidence often fails to distinguish the distinct roles of leisure screen time (LST) quantity and addictive patterns like internet gaming disorder (IGD) on a comprehensive range of mental health outcomes. OBJECTIVE: This study aimed to investigate the independent and joint associations of LST and IGD with multiple mental health conditions among Chinese adolescents. METHODS: We conducted a school-based, cross-sectional survey in Sichuan Province, China. Participants were recruited by random cluster sampling from 20 public schools. The sample comprised 13,240 adolescents (6659/13,240, 50.3% girls) with a mean age of 15.4 (SD 1.6) years. LST was self-reported, and IGD was evaluated using the Internet Gaming Disorder Scale-9 Item Short Form (IGDS9-SF). Mental health outcomes included overall mental health status and 5 specific diseases: psychological distress, depression, paranoia, insomnia, and suicidal ideation, all assessed using validated scales. RESULTS: The prevalence of excessive LST, IGD, and any mental health disorder was 48.2% (6378/13,240; 95% CI 47.3%-49.0%), 1.4% (188/13,240; 95% CI 1.2%-1.6%), and 55.8% (7387/13,240; 95% CI 54.9%-56.7%), respectively. After adjustment, excessive LST (odds ratio [OR] 1.18, 95% CI 1.09-1.27) and IGD (OR 6.58, 95% CI 5.02-8.62) were independently associated with poor mental health. A dose-response relationship existed for LST quartiles (Q2: OR 1.15, 95% CI 1.04-1.26; Q3: OR 1.24, 95% CI 1.12-1.37; Q4: OR 1.31, 95% CI 1.18-1.46; P(trend)<.001). Excessive LST was associated with depression (OR 1.16, 95% CIs 1.05-1.29), paranoia (OR 1.22, 95% CI 1.11-1.34), and suicidal ideation (OR 1.15, 95% CI 1.04-1.28), while IGD was associated with all 5 disorders, most notably depression (OR 6.43, 95% CI 4.56-9.06) and paranoia (OR 5.77, 95% CI 4.05-8.21). IGD consistently demonstrated stronger associations than LST: psychological distress (OR 4.40, 95% CI 3.12-6.19 vs OR 1.14, 95% CI 0.98-1.33), depression (OR 6.43, 95% CI 4.56-9.06 vs OR 1.16, 95% CI 1.05-1.29), paranoia (OR 5.77, 95% CI 4.05-8.21 vs OR 1.22, 95% CI 1.11-1.34), insomnia (OR 2.90, 95% CI 2.09-4.05 vs OR 1.12, 95% CI 102-1.22), and suicidal ideation (OR 3.85, 95% CI 2.76-5.37 vs OR 1.15, 95% CI 1.04-1.28). Adolescents with both excessive LST and IGD demonstrated the highest odds of mental health disorders (OR 7.35, 95% CI 5.29-10.22). No significant interaction was found on additive or multiplicative scales. CONCLUSIONS: Both excessive LST and IGD are independently associated with mental health disorders in adolescents, with IGD showing a substantially stronger association. This study is distinct from prior research by simultaneously investigating both screen time quantity and addictive usage patterns, and by comprehensively assessing 5 distinct mental health outcomes. Longitudinal studies are needed to better understand the long-term effects. CI - (c)Qin Deng, Linna Sha, Jiaojiao Hou, Xunying Zhao, Rong Xiang, Jiangbo Zhu, Yang Qu, Jinyu Zhou, Ting Yu, Xin Song, Sirui Zheng, Tao Han, Bin Yang, Mengyu Fan, Xia Jiang. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 15.01.2026. FAU - Deng, Qin AU - Deng Q AUID- ORCID: 0009-0000-7330-867X AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Sha, Linna AU - Sha L AUID- ORCID: 0009-0005-7117-8804 AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Hou, Jiaojiao AU - Hou J AUID- ORCID: 0009-0001-4073-2711 AD - Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Zhao, Xunying AU - Zhao X AUID- ORCID: 0000-0002-6754-9773 AD - Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Xiang, Rong AU - Xiang R AUID- ORCID: 0000-0002-0123-5544 AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Zhu, Jiangbo AU - Zhu J AUID- ORCID: 0009-0007-3481-0350 AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Qu, Yang AU - Qu Y AUID- ORCID: 0009-0001-0679-0504 AD - Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Zhou, Jinyu AU - Zhou J AUID- ORCID: 0009-0004-6205-0828 AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Yu, Ting AU - Yu T AUID- ORCID: 0000-0002-2294-3291 AD - Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Song, Xin AU - Song X AUID- ORCID: 0000-0003-2343-5835 AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Zheng, Sirui AU - Zheng S AUID- ORCID: 0009-0003-4866-9635 AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Han, Tao AU - Han T AUID- ORCID: 0009-0009-9672-8277 AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Yang, Bin AU - Yang B AUID- ORCID: 0009-0007-0248-3164 AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Fan, Mengyu AU - Fan M AUID- ORCID: 0009-0006-9803-0532 AD - Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Jiang, Xia AU - Jiang X AUID- ORCID: 0000-0001-5878-8986 AD - Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. AD - Department of Epidemiology and Biostatistics, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. AD - Department of Clinical Neuroscience, Center for Molecular Medicine, Karolinska Institutet, Stockholm, Sweden. LA - eng PT - Journal Article DEP - 20260115 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 RN - Chinese people SB - IM MH - Humans MH - Cross-Sectional Studies MH - Adolescent MH - Female MH - Male MH - China/epidemiology MH - *Internet Addiction Disorder/epidemiology/psychology MH - *Mental Health MH - *Screen Time MH - *Leisure Activities MH - *Video Games MH - Mental Disorders/epidemiology MH - Surveys and Questionnaires MH - East Asian People PMC - PMC12856396 OTO - NOTNLM OT - adolescent OT - cross-sectional study OT - internet gaming disorder OT - leisure screen time OT - mental health OT - screen media activity COIS- Conflicts of Interest: None declared. EDAT- 2026/01/15 18:47 MHDA- 2026/01/15 18:48 PMCR- 2026/01/15 CRDT- 2026/01/15 16:56 PHST- 2025/07/15 00:00 [received] PHST- 2025/11/07 00:00 [accepted] PHST- 2026/01/15 18:48 [medline] PHST- 2026/01/15 18:47 [pubmed] PHST- 2026/01/15 16:56 [entrez] PHST- 2026/01/15 00:00 [pmc-release] AID - v28i1e80737 [pii] AID - 10.2196/80737 [doi] PST - epublish SO - J Med Internet Res. 2026 Jan 15;28:e80737. doi: 10.2196/80737. PMID- 41538787 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260826 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Jan 15 TI - Nutrition Education for Emerging Adults: Protocol for Program Evaluation. PG - e81647 LID - 10.2196/81647 [doi] LID - e81647 AB - BACKGROUND: Emerging adults (ie, those aged 18 to 25 years) in the United States exhibit the poorest diet quality among all adult age groups, contributing to adverse health and academic outcomes. Existing nutrition education programs often overlook this population, particularly those without children. OBJECTIVE: This study aims to present the development of a nutrition education curriculum for emerging adults, including its process and outcome evaluation strategies and measures. METHODS: The Fuel to Thrive program was adapted from an established state program for adults. The content was informed by reviewing the literature, conducting focus groups with health educators, and holding regular meetings with a curriculum committee. The final program consists of five 1-hour lessons incorporating nutrition education, recipe demonstrations, and physical activity. Process evaluation will involve focus groups with participants and interviews with educators to assess relevance and feasibility. Outcome evaluation will include surveys administered before and after the program to assess dietary behaviors, physical activity, food safety, and food resource management. RESULTS: The program is currently being piloted at a Texas university. Additional implementations are planned for fall 2025 and spring 2026, with the inclusion of the Short Healthy Eating Index Survey to better assess diet quality changes. CONCLUSIONS: The Fuel to Thrive program addresses a critical gap in nutrition education for emerging adults by offering a tailored curriculum. Future iterations will refine the program based on participant and educator feedback and expand evaluation efforts. The long-term goal is national dissemination to improve dietary behaviors and health outcomes among emerging adults. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/81647. CI - (c)Stephanie Rogus, Katelin Alfaro Hudak, Lilian O Ademu, Sumathi Venkatesh, Michael Laguros, Elizabeth F Racine. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 15.01.2026. FAU - Rogus, Stephanie AU - Rogus S AUID- ORCID: 0000-0003-2086-1732 AD - Texas A&M AgriLife Research Center, El Paso, TX, United States. FAU - Alfaro Hudak, Katelin AU - Alfaro Hudak K AUID- ORCID: 0000-0003-2781-0487 AD - Texas A&M AgriLife Research Center, El Paso, TX, United States. FAU - Ademu, Lilian O AU - Ademu LO AUID- ORCID: 0000-0001-7395-2609 AD - Texas A&M AgriLife Research Center, El Paso, TX, United States. FAU - Venkatesh, Sumathi AU - Venkatesh S AUID- ORCID: 0009-0008-3254-7509 AD - Texas A&M AgriLife Extension Service, College Station, TX, United States. FAU - Laguros, Michael AU - Laguros M AUID- ORCID: 0009-0007-4167-9346 AD - Texas A&M AgriLife Extension Service, College Station, TX, United States. FAU - Racine, Elizabeth F AU - Racine EF AUID- ORCID: 0009-0009-3019-7477 AD - Texas A&M AgriLife Research Center, El Paso, TX, United States. LA - eng PT - Journal Article DEP - 20260115 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - *Program Evaluation/methods MH - *Health Education/methods/standards MH - Curriculum MH - Focus Groups/methods MH - Adolescent MH - Young Adult MH - Texas MH - Adult MH - *Nutritional Sciences/education MH - Female MH - Male PMC - PMC12856397 OTO - NOTNLM OT - curriculum development OT - emerging adults OT - extension OT - nutrition education OT - program evaluation COIS- Conflicts of Interest: None declared. EDAT- 2026/01/15 18:47 MHDA- 2026/01/15 18:48 PMCR- 2026/01/15 CRDT- 2026/01/15 16:55 PHST- 2025/07/31 00:00 [received] PHST- 2025/12/17 00:00 [accepted] PHST- 2026/01/15 18:48 [medline] PHST- 2026/01/15 18:47 [pubmed] PHST- 2026/01/15 16:55 [entrez] PHST- 2026/01/15 00:00 [pmc-release] AID - v15i1e81647 [pii] AID - 10.2196/81647 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Jan 15;15:e81647. doi: 10.2196/81647. PMID- 41538394 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 1 DP - 2026 TI - Concurrent coverage and determinants of vitamin A supplementation and deworming among children aged 12-59 months in 15 Sub-Saharan African countries. PG - e0339759 LID - 10.1371/journal.pone.0339759 [doi] LID - e0339759 AB - BACKGROUND: Vitamin A supplementation (VAS) and deworming (DW) are proven, cost-effective interventions that protect children against preventable morbidity, mortality, and the burden of micronutrient deficiencies and parasitic infections. Nevertheless, many children fail to receive both interventions simultaneously, limiting the potential health gains. Assessing co-coverage and its determinants is crucial for guiding integrated child health strategies and closing persistent gaps across Sub-Saharan Africa. METHODS: We analyzed DHS data from 15 Sub-Saharan African countries, including 107,725 children aged 12-59 months. The primary outcome was co-coverage of vitamin A supplementation and deworming within six months. Weighted descriptive statistics and mixed-effects logistic regression assessed determinants at individual, household, community, and country levels, accounting for survey design and clustering. Variables with p < 0.20 or deemed theoretically relevant were included in the multilevel model (p < 0.05, 95% CI). RESULTS: The pooled co-coverage of vitamin A supplementation (VAS) and deworming (DW) among children aged 12-59 months was 44.0% (95% CI: 43.4-44.6%), despite individual coverage of 57.1% for each intervention. Approximately 13% of children received either Vitamin A or deworming as a single intervention. Nearly 30% of children received neither intervention. Co-coverage was lowest in Sierra Leone (10.3%) and Gabon (13.2%), moderate in Burkina Faso (28.6%), Cote d'Ivoire (31.0%), Mozambique (44.0%), and Tanzania (44.7%), and highest in Lesotho (58.4%) and Rwanda (84.7%). Vitamin A supplementation coverage was lowest in Gabon (15.7%), Sierra Leone (16.5%) and highest in Rwanda (89.1%) and Lesotho (73.6%), while deworming alone was lowest in Sierra Leone (30.3%) and Burkina Faso (36.7%) and highest in Rwanda (89.4%) and Lesotho (62.4%). Co-coverage of vitamin A supplementation and deworming was higher among children aged 24-47 months (AOR = 1.07), fully immunized children (AOR = 1.41), and those with older, educated mothers who attended antenatal care (AORs 1.14-1.59) or had media exposure (AOR = 1.13). Household wealth also increased the likelihood (AORs 1.27-1.64), while urban residence reduced it (AOR = 0.84). At the country level, compared with Burkina Faso, Rwanda (AOR = 20.05), Mauritania (AOR = 4.30), and Lesotho (AOR = 3.92) had the highest odds, whereas Gabon (AOR = 0.36) and Sierra Leone (AOR = 0.22) had the lowest inter-country disparities in integrated child health coverage. The intraclass correlation coefficient (ICC) indicated that approximately 21.6% of the variance in concurrent coverage was attributable to between-country differences. CONCLUSION: Co-coverage of vitamin A supplementation and deworming in 15 sub-Saharan Africa countries is low, with only 44% of children aged 12-59 months receiving both interventions, far below the WHO 80% target. Coverage varied widely, with Rwanda leading and Sierra Leone and Gabon lagging. Strengthened harmonized campaigns, routine service integration, and targeted outreach are essential to improve equitable child health outcomes. CI - Copyright: (c) 2026 Yewodiaw et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Yewodiaw, Thomas Kidanemariam AU - Yewodiaw TK AUID- ORCID: 0009-0009-1491-1044 AD - Medical Officer at International Medical Corps, Amhara Region Emergency Operation Center, Gondar Field Office, Gondar, Ethiopia. FAU - Bitewa, Mequanint Dessie AU - Bitewa MD AD - Department of Public Health, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia. FAU - Tareke, Abiyu Abadi AU - Tareke AA AD - Nossal Institute for Global Health, Melbourne School of Population and Global Health, University of Melbourne, Level 2, Carlton, Victoria, Australia. LA - eng PT - Journal Article DEP - 20260115 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 11103-57-4 (Vitamin A) RN - 0 (Anthelmintics) SB - IM EIN - PLoS One. 2026 Mar 9;21(3):e0344650. doi: 10.1371/journal.pone.0344650. PMID: 41801846 MH - Humans MH - *Vitamin A/administration & dosage/therapeutic use MH - Infant MH - *Dietary Supplements MH - Child, Preschool MH - Africa South of the Sahara/epidemiology MH - Female MH - Male MH - Vitamin A Deficiency MH - *Anthelmintics/therapeutic use PMC - PMC12806840 COIS- No competing interest. EDAT- 2026/01/15 18:47 MHDA- 2026/01/15 18:48 PMCR- 2026/01/15 CRDT- 2026/01/15 13:33 PHST- 2025/08/31 00:00 [received] PHST- 2025/12/11 00:00 [accepted] PHST- 2026/01/15 18:48 [medline] PHST- 2026/01/15 18:47 [pubmed] PHST- 2026/01/15 13:33 [entrez] PHST- 2026/01/15 00:00 [pmc-release] AID - PONE-D-25-47082 [pii] AID - 10.1371/journal.pone.0339759 [doi] PST - epublish SO - PLoS One. 2026 Jan 15;21(1):e0339759. doi: 10.1371/journal.pone.0339759. eCollection 2026. PMID- 41537899 OWN - NLM STAT- MEDLINE DCOM- 20260115 LR - 20260920 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 2 DP - 2026 Jan 15 TI - Validation of an accelerometer system for activity monitoring in children with functional disabilities. PG - 78 LID - 10.1007/s00431-025-06679-4 [doi] LID - 78 AB - To assess the validity of the SENS motion(R) system (SENS) for measuring postures and movements in school-aged children with functional disabilities, using direct video observation as the criterion method. In this cross-sectional-study, 29 children (51.7% male, mean age 10.8 +/- 2.9 years) from two special schools in Denmark participated. Each child wore a SENS device on the thigh while completing a standardized protocol of six categories: lying/sitting, standing, walking, running, cycling, and step count. All activities were video recorded. Video data were coded in 5-s epochs and aligned with SENS output. Agreement was assessed by comparing the observed time spent in each activity with the corresponding time estimated by SENS, expressed as mean values, standard deviations, mean differences, and percentage agreement. SENS showed excellent agreement for walking (93.2%) and lying/sitting (96.2%), good agreement for running (89.2%), and moderate agreement for standing (74.1%). Cycling was poorly detected, with only 6.4% agreement, as it was frequently misclassified as walking (50.8%) or lying/sitting (42.7%). Step counts were slightly overestimated by SENS (mean difference 7.2 steps). Overall, SENS tended to underestimate activity duration compared with the observation. CONCLUSION: SENS demonstrated excellent to good validity for detecting lying/sitting, walking, and acceptable validity for running in children with functional disabilities, but moderate validity for standing and limited validity for cycling. These findings indicate that SENS may be useful for monitoring several common postures and activities in this population, though further algorithm refinement and broader validation are needed, particularly for cycling and postural transitions. WHAT IS KNOWN: * Children with disabilities engage in less dynamic postures and more lying/sitting time than their peers without disabilities. * Accelerometer systems are typically validated in healthy populations, limiting accuracy in children with disabilities. WHAT IS NEW: * SENS shows excellent to good validity for lying/sitting, walking, and running in children with functional disabilities. * SENS performs poorly for cycling and moderately for standing, highlighting the need for algorithm refinement. CI - (c) 2025. The Author(s). FAU - Stage, Anna AU - Stage A AUID- ORCID: 0000-0003-1198-727X AD - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. anna.stage.hansen@regionh.dk. AD - Department of Nutrition, Exercise, and Sports, University of Copenhagen, Copenhagen, Denmark. anna.stage.hansen@regionh.dk. FAU - Fromberg, Emil Buch AU - Fromberg EB AD - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. FAU - Elsborg, Peter AU - Elsborg P AD - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. FAU - Kristensen, Mette Ron AU - Kristensen MR AD - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. AD - Interdisciplinary Competence Center - Health Care Services, Allerod Municipality, Allerod, Denmark. FAU - Mikkelsen, Silje AU - Mikkelsen S AD - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. AD - Center for Child and Youth Services, Educational Psychological Counseling, Ballerup Municipality, Ballerup, Denmark. FAU - Bolling, Mads AU - Bolling M AD - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. AD - Research Centre for Didactics and Pedagogy, Program On Outdoor Pedagogy, VIA University College, Aarhus, Denmark. FAU - Aadahl, Mette AU - Aadahl M AD - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. AD - Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. FAU - Stahlhut, Michelle AU - Stahlhut M AD - Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark. LA - eng PT - Journal Article PT - Validation Study DEP - 20260115 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Child MH - *Accelerometry/instrumentation/methods MH - Cross-Sectional Studies MH - Male MH - *Children with Disabilities MH - Female MH - Reproducibility of Results MH - Posture/physiology MH - Denmark MH - Adolescent MH - Walking PMC - PMC12808203 OTO - NOTNLM OT - Accelerometry OT - Children OT - Functional disabilities OT - Physical activity OT - Sedentary behavior OT - Validation COIS- Declarations. Ethics approval and consent to participate: The study was carried out in accordance with the principles of the Declaration of Helsinki. Written and verbal informed consent was obtained from the parents of all participating children. In addition, approval from the National Committee on Health Research Ethics was not required (Record no. F-23018545). Competing interests: The authors declare no competing interests. EDAT- 2026/01/15 18:47 MHDA- 2026/01/15 18:48 PMCR- 2026/01/15 CRDT- 2026/01/15 11:05 PHST- 2025/10/22 00:00 [received] PHST- 2025/11/30 00:00 [accepted] PHST- 2025/11/18 00:00 [revised] PHST- 2026/01/15 18:48 [medline] PHST- 2026/01/15 18:47 [pubmed] PHST- 2026/01/15 11:05 [entrez] PHST- 2026/01/15 00:00 [pmc-release] AID - 10.1007/s00431-025-06679-4 [pii] AID - 6679 [pii] AID - 10.1007/s00431-025-06679-4 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jan 15;185(2):78. doi: 10.1007/s00431-025-06679-4. PMID- 41536385 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260115 LR - 20260117 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 12 DP - 2025 Dec TI - Identification and Evaluation of Menstruation-Related Disorders in Adolescent Girls Attending a Tertiary Care Center: An Observational Study. PG - e99192 LID - 10.7759/cureus.99192 [doi] LID - e99192 AB - Background Menstrual disorders such as dysmenorrhea, menorrhagia, oligomenorrhea, and premenstrual syndrome are believed to be the most common yet under-recognized causes of morbidity in adolescent girls. Many adolescents around the world experience menstrual dysfunction, and in India, cultural stigma, poor awareness, and nutritional imbalance are believed to exacerbate the burden. Despite national initiatives focusing on menstrual hygiene and anemia prevention, only a few studies in India have systematically evaluated the clinical spectrum, determinants, and functional impact of menstrual disorders in tertiary-care settings. This study aimed to assess the prevalence, pattern, and clinical correlates of menstruation-related disorders among adolescent girls attending a teaching hospital in South India and to identify the functional limitations imposed by these conditions. Methods A hospital-based cross-sectional observational study was conducted among 72 post-menarcheal adolescent girls (10-19 years) attending the outpatient department of Obstetrics and Gynecology, Sree Balaji Medical College and Hospital, Chennai. Participants were assessed using a validated, semi-structured questionnaire covering sociodemographic data, menstrual characteristics, hygiene practices, and psychosocial impact. Clinical evaluation included anthropometry, hemoglobin estimation, thyroid function testing, and pelvic ultrasonography where indicated. The severity of symptoms and functional disability were assessed using the Pictorial Blood Assessment Chart (PBAC), Visual Analogue Scale (VAS), and WHO Disability Assessment Schedule (WHODAS 2.0). Results The mean age at menarche was 12.6 +/- 1.2 years, with 69.4% reporting regular cycles and a mean duration of flow of 4.9 +/- 1.6 days. The overall prevalence of menstrual disorders was strikingly high (94.4%). Dysmenorrhea (72.2%) and premenstrual syndrome (75.0%) were the most common, followed by menorrhagia (25%) and oligomenorrhea (13.9%). Anemia was observed in 33.3%, thyroid abnormalities in 8.3%, and polycystic ovary syndrome (PCOS) features in 13.9% on ultrasonography. Overweight and obesity were significantly associated with menstrual irregularities (p=0.013). Functionally, participants missed an average of 1.8 +/- 0.9 school days per cycle, with 38.9% reporting absenteeism and 47.2% restricting social or physical activities. The mean WHODAS disability score was 8.6 +/- 3.5, showing a strong correlation (r=0.62; p<0.001) with menstrual symptom severity. Conclusion Menstrual disorders are highly prevalent among adolescents and impose significant physical and psychosocial burdens. Integrating menstrual health education, nutritional interventions, and early clinical screening into adolescent programs is vital to improving reproductive health and educational outcomes. CI - Copyright (c) 2025, Prem et al. FAU - Prem, Pragya AU - Prem P AD - Obstetrics and Gynaecology, Sree Balaji Medical College and Hospital, Chennai, IND. FAU - S R, Veena AU - S R V AD - Obstetrics and Gynaecology, Sree Balaji Medical College and Hospital, Chennai, IND. FAU - T S, Meena AU - T S M AD - Obstetrics and Gynaecology, Sree Balaji Medical College and Hospital, Chennai, IND. FAU - T G, Revathy AU - T G R AD - Obstetrics and Gynaecology, Sree Balaji Medical College and Hospital, Chennai, IND. LA - eng PT - Journal Article DEP - 20251214 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12798763 OTO - NOTNLM OT - adolescent health OT - anemia OT - dysmenorrhea OT - india OT - menorrhagia OT - menstrual hygiene OT - premenstrual syndrome OT - school absenteeism OT - whodas COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Human Ethics Committee, Sree Balaji Medical College and Hospital issued approval 002/SBMCH/IHEC/2025/2535. Ethical approval for the study was obtained from the Institutional Human Ethics Committee of Sree Balaji Medical College and Hospital, Chennai (Ref No: 002/SBMCH/IHEC/2025/2535). Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2026/01/15 07:55 MHDA- 2026/01/15 07:56 PMCR- 2025/12/14 CRDT- 2026/01/15 04:24 PHST- 2025/12/14 00:00 [accepted] PHST- 2026/01/15 07:56 [medline] PHST- 2026/01/15 07:55 [pubmed] PHST- 2026/01/15 04:24 [entrez] PHST- 2025/12/14 00:00 [pmc-release] AID - 10.7759/cureus.99192 [doi] PST - epublish SO - Cureus. 2025 Dec 14;17(12):e99192. doi: 10.7759/cureus.99192. eCollection 2025 Dec. PMID- 41536276 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260115 LR - 20260115 IS - 2575-9108 (Electronic) IS - 2575-9108 (Linking) VI - 9 IP - 1 DP - 2026 Jan 9 TI - Measurement of Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) and Alkyl-diacylglycerol (TG(O)) from Human Breast Milk. PG - 101-113 LID - 10.1021/acsptsci.5c00601 [doi] AB - Fatty acid esters of hydroxy fatty acids (FAHFAs) and alkyl-diacylglycerols (TG-(O)-s) are endogenous lipids that exert protective effects against diabetes, inflammation, and the development of childhood obesity. They have been identified as minor lipids in human breast milk, and an accurate characterization of FAHFAs and TG-(O)-s could further our understanding of changes in human milk lipid profiles across different phenotypes. However, due to differences in their polarities and chemical properties, current studies on FAHFAs and TG-(O)-s tend to be conducted independently. The study of these compounds is further complicated by a shortage of validated methods for the isolation of FAHFAs and TG-(O)-s from complex, lipid-rich biological matrices, such as human breast milk. Additionally, cohort studies on human tissues, including breast milk, are often confronted with limited sample availability. In this study, we describe the systematic validation of a workflow to reliably extract, isolate, and characterize both FAHFAs and TG-(O)-s from 1.6 mL of human breast milk. We have applied this method to the measurement of 16 and 19 endogenous FAHFA and TG-(O) species originating from two cohort studies, respectively. Our validated workflow also includes the application of liquid chromatography-multistage mass spectrometry approaches to identify FAHFA and TG-(O) molecular species as well as FAHFA regioisomers. This method has the potential to be adapted for the isolation and characterization of other minor lipids with different polarities from limited sample volumes of complex biological matrices. CI - (c) 2025 American Chemical Society. FAU - Lee, Megan Li Xian AU - Lee MLX AUID- ORCID: 0000-0002-4888-2845 AD - Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. RINGGOLD: 37580 AD - Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore 117456, Singapore. AD - Wilmar Innovation Center, Wilmar International HQ, Singapore 138568, Singapore. RINGGOLD: 245010 FAU - Nguyen, Kim Ngan T AU - Nguyen KNT AD - Wilmar Innovation Center, Wilmar International HQ, Singapore 138568, Singapore. RINGGOLD: 245010 FAU - Pang, Wei Wei AU - Pang WW AD - Global Center for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore. AD - Bia-Echo Asia Centre for Reproductive Longevity and Equality, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117456, Singapore. AD - Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore and National University Health System, Singapore 119228, Singapore. FAU - Torta, Federico AU - Torta F AUID- ORCID: 0000-0001-7545-7484 AD - Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore 117456, Singapore. AD - Department of Biochemistry and Precision Medicine TRP, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore. AD - Signature Research Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore (NUS) Medical School, Singapore 169857, Singapore. FAU - Chong, Yap Seng AU - Chong YS AD - Singapore Institute for Clinical Sciences, A*STAR, Singapore 117609, Singapore. RINGGOLD: 54759 AD - Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. FAU - Eriksson, Johan G AU - Eriksson JG AD - Singapore Institute for Clinical Sciences, A*STAR, Singapore 117609, Singapore. RINGGOLD: 54759 AD - Department of Obstetrics and Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore. AD - Folkhalsan Research Center, 00250 Helsinki, Finland. AD - Department of General Practice and Primary Health Care, University of Helsinki, 00290 Helsinki, Finland. FAU - Chan, Jerry Kok Yen AU - Chan JKY AD - Duke-National University of Singapore (NUS) Medical School, Singapore 169857, Singapore. AD - Department of Maternal Fetal Medicine, KK Women's and Children's Hospital, Singapore 229899, Singapore. FAU - Elejalde, Untzizu AU - Elejalde U AD - Wilmar Innovation Center, Wilmar International HQ, Singapore 138568, Singapore. RINGGOLD: 245010 FAU - Cazenave-Gassiot, Amaury AU - Cazenave-Gassiot A AUID- ORCID: 0000-0002-3050-634X AD - Singapore Lipidomics Incubator, Life Sciences Institute, National University of Singapore, Singapore 117456, Singapore. AD - Department of Biochemistry and Precision Medicine TRP, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117596, Singapore. LA - eng PT - Journal Article DEP - 20251209 PL - United States TA - ACS Pharmacol Transl Sci JT - ACS pharmacology & translational science JID - 101721411 PMC - PMC12797159 OTO - NOTNLM OT - FAHFAs OT - TG(O)s OT - breast milk OT - lipids EDAT- 2026/01/15 07:55 MHDA- 2026/01/15 07:56 PMCR- 2026/12/09 CRDT- 2026/01/15 04:23 PHST- 2025/09/01 00:00 [received] PHST- 2025/11/25 00:00 [revised] PHST- 2025/12/02 00:00 [accepted] PHST- 2026/01/15 07:56 [medline] PHST- 2026/01/15 07:55 [pubmed] PHST- 2026/01/15 04:23 [entrez] PHST- 2026/12/09 00:00 [pmc-release] AID - 10.1021/acsptsci.5c00601 [doi] PST - epublish SO - ACS Pharmacol Transl Sci. 2025 Dec 9;9(1):101-113. doi: 10.1021/acsptsci.5c00601. eCollection 2026 Jan 9. PMID- 41536238 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260827 IS - 1949-0984 (Electronic) IS - 1949-0976 (Print) IS - 1949-0976 (Linking) VI - 18 IP - 1 DP - 2026 Dec 31 TI - Maternal obesity alters human milk oligosaccharides content and correlates with early acquisition of late colonizers in the neonatal gut microbiome. PG - 2607043 LID - 10.1080/19490976.2025.2607043 [doi] LID - 2607043 AB - Metabolic and immune development in neonates are shaped by the succession of the gut microbiome. Maternal obesity can perturb this process by altering interactions of human milk bioactive elements, including oligosaccharides (HMOs), microbial populations, and metabolites. We conducted a longitudinal study of Mexican mother-infant dyads to examine maternal BMI-associated variations in HMOs and infant fecal microbiota. Breastmilk samples from 97 mothers were collected at 48 h, one month, and three months postpartum. We used targeted and untargeted metabolomics to profile breastmilk samples, while shotgun metagenomics was used to analyze infant fecal microbiome composition in a subset of samples. Mothers with obesity showed decreased concentration of key HMOs shortly after birth, correlating with an altered succession of their infant's gut microbiota. This included reduced early colonizers (Enterobacteriaceae) and increased abundance of intermediate and late colonizers (Bifidobacterium and members of the Lachnospiraceae family), over subsequent months. These taxa negatively correlated with HMOs such as 6'SL, LNnT, and LNT. Additionally, functional profiling revealed alterations in metabolic pathways related to polyamine biosynthesis, suggesting changes in microbial metabolism linked to maternal BMI. Despite the cohort's size, our study offers unique insights into the relationship between maternal obesity, HMO composition, and early infant microbial colonization in Latin-American mothers. This exploratory research serves as proof of concept, underscoring the need for larger-scale studies to validate these findings and better understand their implications for infant health. More importantly, our results highlight the interplay between maternal BMI and human milk bioactives, underscoring the importance of correlating microbial succession with maternal metabolic health to better understand early immune development in neonates. FAU - Corona-Cervantes, Karina AU - Corona-Cervantes K AUID- ORCID: 0000-0003-1370-9601 AD - Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico. AD - Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, NL, Mexico. FAU - Urrutia-Baca, Victor H AU - Urrutia-Baca VH AUID- ORCID: 0000-0002-5929-5160 AD - Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico. FAU - Gamez-Valdez, July S AU - Gamez-Valdez JS AUID- ORCID: 0000-0001-7115-3678 AD - Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico. AD - Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, NL, Mexico. FAU - Jimenez-Lopez, Brenda AU - Jimenez-Lopez B AUID- ORCID: 0009-0003-4242-133X AD - Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico. AD - Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, NL, Mexico. FAU - Rodriguez-Gutierrez, Nora A AU - Rodriguez-Gutierrez NA AUID- ORCID: 0000-0003-1972-0625 AD - Hospital Regional Materno Infantil, Servicios de Salud de Nuevo Leon, OPD, Ciudad Guadalupe, NL, Mexico. FAU - Chavez-Caraza, Karla AU - Chavez-Caraza K AD - Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud, Monterrey, NL, Mexico. FAU - Espiricueta-Candelaria, Francisca AU - Espiricueta-Candelaria F AUID- ORCID: 0009-0005-6943-7790 AD - Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico. FAU - Villalobos, Ulises A Salas AU - Villalobos UAS AUID- ORCID: 0000-0002-7702-6458 AD - Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, NL, Mexico. FAU - Ramos-Parra, Perla A AU - Ramos-Parra PA AUID- ORCID: 0000-0002-8972-8035 AD - Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, NL, Mexico. FAU - Uribe, Janet A Gutierrez AU - Uribe JAG AUID- ORCID: 0000-0003-1056-7126 AD - Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico. AD - Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, NL, Mexico. FAU - Brunck, Marion AU - Brunck M AUID- ORCID: 0000-0001-8994-8276 AD - Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico. AD - Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, NL, Mexico. FAU - Chuck-Hernandez, Cristina AU - Chuck-Hernandez C AUID- ORCID: 0000-0002-3555-4826 AD - Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico. AD - Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, NL, Mexico. FAU - Licona-Cassani, Cuauhtemoc AU - Licona-Cassani C AUID- ORCID: 0000-0002-0360-3945 AD - Tecnologico de Monterrey, Institute for Obesity Research, Monterrey, NL, Mexico. AD - Tecnologico de Monterrey, Escuela de Ingenieria y Ciencias, Monterrey, NL, Mexico. AD - Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico. LA - eng SI - SRA/SUB15262662 SI - BioProject/PRJNA1260751 PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260115 PL - United States TA - Gut Microbes JT - Gut microbes JID - 101495343 RN - 0 (Oligosaccharides) SB - IM MH - Humans MH - *Milk, Human/chemistry/metabolism MH - Female MH - *Oligosaccharides/metabolism/analysis MH - Infant, Newborn MH - Feces/microbiology MH - Adult MH - *Gastrointestinal Microbiome MH - Pregnancy MH - Longitudinal Studies MH - *Bacteria/classification/isolation & purification/genetics/metabolism MH - *Obesity/metabolism/microbiology MH - Infant MH - Mexico MH - Body Mass Index MH - Metagenomics MH - Young Adult MH - *Pregnancy in Obesity/metabolism/microbiology MH - Mothers PMC - PMC12818807 OTO - NOTNLM OT - HMOs OT - gut microbiome OT - human milk OT - metagenomics OT - obesity OT - succession of gut microbiome COIS- The authors report that there are no competing interests to declare. EDAT- 2026/01/15 07:55 MHDA- 2026/01/15 07:56 PMCR- 2026/01/15 CRDT- 2026/01/15 04:03 PHST- 2026/01/15 07:56 [medline] PHST- 2026/01/15 07:55 [pubmed] PHST- 2026/01/15 04:03 [entrez] PHST- 2026/01/15 00:00 [pmc-release] AID - 2607043 [pii] AID - 10.1080/19490976.2025.2607043 [doi] PST - ppublish SO - Gut Microbes. 2026 Dec 31;18(1):2607043. doi: 10.1080/19490976.2025.2607043. Epub 2026 Jan 15. PMID- 41536000 OWN - NLM STAT- MEDLINE DCOM- 20260210 LR - 20260626 IS - 2072-1315 (Electronic) IS - 1606-0997 (Print) IS - 1606-0997 (Linking) VI - 45 IP - 1 DP - 2026 Jan 14 TI - A comparative study of ordinal logistic regression and machine learning models for predicting women's malnutrition in bangladesh: evidence from BDHS 2022. PG - 56 LID - 10.1186/s41043-025-01236-z [doi] LID - 56 AB - Malnutrition, including both undernutrition and overnutrition, remains a major public health concern in Bangladesh, particularly among women of reproductive age. This study aims to identify key determinants of women's malnutrition in Bangladesh and compare the predictive performance of ordinal logistic regression and machine learning methods for predicting women's malnutrition using data from the 2022 Bangladesh Demographic and Health Survey. This study utilized data from 8,728 ever-married women aged 15-49 years extracted from the BDHS 2022. Six ML algorithms, including Random Forest, Extreme Gradient Boosting (XGBoost), Support Vector Machine, Naive Bayes, AdaBoost, and Multilayer Perceptron (MLP), were compared with ordinal logistic regression by evaluating their performances using accuracy, precision, recall, [Formula: see text] score, Cohen's kappa, and area under the curve (AUC). Data preprocessing included SMOTE to address class imbalance, and models were assessed using stratified k-fold cross-validation. Findings of Ordinal Logistic Regression (OLR) suggest that age, division, residence, wealth index, current breastfeeding status, husband's education, currently working, and age at first marriage are the significant predictors of women's malnutrition. However, its predictive performance was modest, with an accuracy of 49% and macro-averaged [Formula: see text] score was 0.47. In contrast, ML models outperformed OLR across all evaluation metrics. Random Forest and XGBoost achieved the highest test accuracy (64%), with Random Forest attaining a macro-averaged [Formula: see text] score of 0.64 and achieved 66.2% accuracy (10-fold CV). Traditional models, such as OLR, are more explainable, but machine learning models demonstrate higher accuracy in classifying malnutrition. The findings can help policymakers and health professionals prioritize resources and plan targeted nutrition programs, considering the risk factors identified in this study, to lessen the burden of both undernutrition and overnutrition among women in Bangladesh. CI - (c) 2026. The Author(s). FAU - Kulsum, Umme AU - Kulsum U AD - Department of Statistics and Data Science, University of Barishal, Barishal, 8254, Bangladesh. FAU - Haque, Ahsanul AU - Haque A AD - Department of Statistics and Data Science, University of Barishal, Barishal, 8254, Bangladesh. FAU - Barai, Pallab AU - Barai P AD - Department of Statistics and Data Science, University of Barishal, Barishal, 8254, Bangladesh. FAU - Hossain, Md Moyazzem AU - Hossain MM AUID- ORCID: 0000-0003-3593-6936 AD - Department of Statistics and Data Science, Jahangirnagar University, Savar, Dhaka-1342, Bangladesh. hossainmm@juniv.edu. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260114 PL - Bangladesh TA - J Health Popul Nutr JT - Journal of health, population, and nutrition JID - 100959228 SB - IM MH - Female MH - Humans MH - Bangladesh/epidemiology MH - *Malnutrition/epidemiology/diagnosis MH - Logistic Models MH - Adult MH - *Machine Learning MH - Middle Aged MH - Adolescent MH - Predictive Learning Models MH - Young Adult MH - Boosting Machine Learning Algorithms MH - Random Forest MH - Classification Algorithms MH - Health Surveys MH - Prediction Algorithms PMC - PMC12888648 OTO - NOTNLM OT - Bangladesh OT - Machine learning OT - Malnutrition OT - Ordinal logistic regression COIS- Declarations. Ethics approval and consent to participate: This study is based on publicly available secondary data. The initial survey obtained participants' consent, and ethical approval was granted by the Ethics Committee of the ICF Macro at Calverton in the USA and the local Ethics Committee in Bangladesh. Consent to participate: Confirming that all participants provided informed and voluntary consent before being interviewed or undergoing biomarker tests. Competing interests: The authors declare no competing interests. EDAT- 2026/01/15 07:55 MHDA- 2026/02/10 06:31 PMCR- 2026/01/14 CRDT- 2026/01/15 00:22 PHST- 2025/11/03 00:00 [received] PHST- 2025/12/28 00:00 [accepted] PHST- 2026/02/10 06:31 [medline] PHST- 2026/01/15 07:55 [pubmed] PHST- 2026/01/15 00:22 [entrez] PHST- 2026/01/14 00:00 [pmc-release] AID - 10.1186/s41043-025-01236-z [pii] AID - 1236 [pii] AID - 10.1186/s41043-025-01236-z [doi] PST - epublish SO - J Health Popul Nutr. 2026 Jan 14;45(1):56. doi: 10.1186/s41043-025-01236-z. PMID- 41535813 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2026 Jan 14 TI - Association and predictive value of blood branched-chain and excitatory amino acids with autism spectrum disorder severity. LID - 10.1186/s12887-025-06501-y [doi] LID - 156 AB - BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with heterogeneous severity. Abnormal amino acid metabolism may contribute to ASD pathogenesis, but the relationship between amino acid levels and severity remains unclear. This study investigated the association and predictive value of blood amino acid profiles for ASD severity. METHODS: We enrolled 474 children with ASD, divided into mild-to-moderate (CARS 30-36, n = 123) and severe groups (CARS 37-60, n = 351). Tandem mass spectrometry measured blood branched-chain amino acids (BCAAs) and excitatory amino acids (EAAs). Multivariate logistic and restricted cubic spline regressions analyzed associations and dose-response relationships. Model performance was evaluated by ROC, calibration, and decision curve analysis. RESULTS: The severe group had higher total BCAAs (307.50 +/- 79.94 vs. 284.74 +/- 70.51 micromol/L, P = 0.005) and EAAs (245.18 +/- 72.02 vs. 227.83 +/- 67.32 micromol/L, P = 0.020). After full adjustment, leucine/isoleucine showed the strongest association with severe ASD (OR = 1.012, 95% CI: 1.006-1.018, P < 0.001), followed by glutamate (OR = 1.005, 95% CI: 1.002-1.009, P = 0.006). BCAAs, leucine/isoleucine, and EAAs exhibited linear positive correlations with severe ASD risk; glutamate showed nonlinear association. Leucine/isoleucine had optimal predictive performance (AUC = 0.807, 95% CI: 0.765-0.849; sensitivity 69.80%, specificity 76.42% at 125.595 micromol/L). Subgroup analysis indicated that the associations between amino acids and ASD severity were stronger in children 3h p/day). We provide a foundation for future larger-scale studies on effectiveness of increased dosage of physical rehabilitation on daily functioning and participation of children and adolescents with ABI. FAU - Gmelig Meyling, Christiaan AU - Gmelig Meyling C AD - UMC Utrecht Brain Center and Center of Excellence for Rehabilitation Medicine, Utrecht University, Utrecht, The Netherlands. AD - Department of Pediatric Rehabilitation, De Hoogstraat Rehabilitation, Utrecht, The Netherlands. AD - HU University of Applied Sciences Utrecht, Institute of Human Movement Studies, Utrecht, The Netherlands. FAU - Rentinck, Ingrid AU - Rentinck I AD - Department of Pediatric Psychology, Wilhelmina's Children Hospital, University Medical Center Utrecht, The Netherlands. FAU - Verschuren, Olaf AU - Verschuren O AD - UMC Utrecht Brain Center and Center of Excellence for Rehabilitation Medicine, Utrecht University, Utrecht, The Netherlands. FAU - van der Steen, Irene AU - van der Steen I AD - Department of Pediatric Rehabilitation, De Hoogstraat Rehabilitation, Utrecht, The Netherlands. FAU - Engelbert, Raoul AU - Engelbert R AD - Department of Rehabilitation, Amsterdam Movement Sciences, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands. AD - Faculty of Health, Centre of Expertise Urban Vitality, Amsterdam University of Applied Sciences, Amsterdam, The Netherlands. AD - Department of Pediatrics, Amsterdam UMC, Emma Children's Hospital, University of Amsterdam, Amsterdam, The Netherlands. FAU - Gorter, Jan Willem AU - Gorter JW AD - UMC Utrecht Brain Center and Center of Excellence for Rehabilitation Medicine, Utrecht University, Utrecht, The Netherlands. AD - Department of Rehabilitation, Physical Therapy Science & Sports, UMC Utrecht Brain Center, University Medical Center Utrecht, Utrecht, The Netherlands. AD - Department of Pediatrics, CanChild Centre for Childhood Disability Research, McMaster University, Hamilton, ON, Canada. LA - eng PT - Journal Article DEP - 20260113 PL - England TA - Disabil Rehabil JT - Disability and rehabilitation JID - 9207179 SB - IM MH - Humans MH - Adolescent MH - Child MH - *Brain Injuries/rehabilitation MH - Female MH - Feasibility Studies MH - Male MH - Prospective Studies MH - Young Adult MH - Treatment Outcome MH - Cognition MH - Recovery of Function MH - *Exercise Therapy/methods MH - Activities of Daily Living MH - Exercise OAB - High-intensity physical rehabilitation is feasible and safe in children and adolescents with acquired brain injury during the subacute rehabilitation phaseThe majority of children in our study reached > 3 hours of physical activity per day during inpatient rehabilitationInterdisciplinary collaboration with families and rehabilitation professionals enhances physical practice throughout the day and weekThe use of a core set of clinical outcome measures facilitates evaluating the effectiveness of interventions. OABL- eng OTO - NOTNLM OT - Rehabilitation OT - acquired brain injury OT - children OT - neural plasticity OT - physical activity EDAT- 2026/01/14 07:05 MHDA- 2026/07/12 00:54 CRDT- 2026/01/14 01:53 PHST- 2026/07/12 00:54 [medline] PHST- 2026/01/14 07:05 [pubmed] PHST- 2026/01/14 01:53 [entrez] AID - 10.1080/09638288.2026.2614948 [doi] PST - ppublish SO - Disabil Rehabil. 2026 Jul;48(15):4810-4822. doi: 10.1080/09638288.2026.2614948. Epub 2026 Jan 13. PMID- 41529935 OWN - NLM STAT- MEDLINE DCOM- 20260722 LR - 20260722 IS - 1468-2079 (Electronic) IS - 0007-1161 (Linking) VI - 110 IP - 8 DP - 2026 Jul 22 TI - Cycloplegic autorefraction doubles diagnostic yield of myopia compared to vision testing: findings from a decade-long screening programme. PG - 922-928 LID - 10.1136/bjo-2025-328039 [doi] AB - BACKGROUND: Cycloplegic autorefraction may offer higher diagnostic accuracy than uncorrected visual acuity (VA) screening. We aimed to evaluate diagnostic yield and risk factors for previously unrecognised myopia. METHODS: This repeated cross-sectional study analysed data from 33 642 kindergarteners aged 5-6 years enrolled in the Yilan Myopia Prevention and Vision Improvement Program from 2014 to 2024. Participants underwent uncorrected VA testing and on-site cycloplegic autorefraction. Caregivers completed questionnaires on myopia-related behaviours. Previously unrecognised or newly detected myopia (NDM), defined as spherical equivalent /=2 hours/day (OR, 1.13; 95% CI 1.03 to 1.23) and outdoor time >/=2 hours/day (OR, 0.85; 95% CI 0.78 to 0.94). In contrast, previously detected myopia showed no association with these modifiable factors. CONCLUSIONS: Preschool myopia screening using cycloplegic autorefraction significantly improves early detection compared with VA screening. Timely diagnosis raises parental awareness and empowers children to modify myopia-related behaviours. CI - (c) Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Wang, Chiao-Yu AU - Wang CY AD - Department of Ophthalmology, National Yang Ming Chiao Tung University Hospital, Yilan, Taiwan. FAU - Yang, Yu-Chieh AU - Yang YC AUID- ORCID: 0000-0002-5774-038X AD - Department of Ophthalmology, National Yang Ming Chiao Tung University Hospital, Yilan, Taiwan. AD - Department of Ophthalmology, Taipei Veterans General Hospital, Taipei City, Taiwan. FAU - Yang, Hsin-Yu AU - Yang HY AUID- ORCID: 0000-0001-5168-8261 AD - Department of Ophthalmology, National Yang Ming Chiao Tung University Hospital, Yilan, Taiwan. AD - Department of Ophthalmology, Yuanshan and Suao Branch, Taipei Veterans General Hospital, Yilan, Taiwan. AD - Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan. FAU - Fang, Shao-You AU - Fang SY AD - Center for Healthcare Policy and Research, University of California Davis, Davis, California, USA. FAU - Shyong, Mong-Ping AU - Shyong MP AD - Department of Ophthalmology, National Yang Ming Chiao Tung University Hospital, Yilan, Taiwan. AD - Department of Ophthalmology, Yuanshan and Suao Branch, Taipei Veterans General Hospital, Yilan, Taiwan. FAU - Lee, Chia-Wei AU - Lee CW AD - Department of Ophthalmology, Fu Jen Catholic University Hospital, New Taipei, Taiwan. AD - School of Medicine, Fu Jen Catholic University, New Taipei, Taiwan. FAU - Huang, Pei-Wei AU - Huang PW AD - Department of Ophthalmology, Lo-Hsu Medical Foundation Lotung Poh-Ai Hospital, Yilan, Taiwan. FAU - Chen, Yen-Lin AU - Chen YL AD - Public Health Bureau, Yilan County, Taiwan. FAU - Hsu, Nai-Wei AU - Hsu NW AD - Public Health Bureau, Yilan County, Taiwan. AD - Department of Internal Medicine, National Yang-Ming University Hospital, Yilan, Taiwan. AD - School of Medcine, National Yang Ming Chiao Tung University, Taipei, Taiwan. AD - National Yang Ming Chiao Tung University Institute of Public Health, Taipei City, Taiwan. FAU - Tsai, Der-Chong AU - Tsai DC AUID- ORCID: 0000-0002-2239-1132 AD - Department of Ophthalmology, National Yang Ming Chiao Tung University Hospital, Yilan, Taiwan dctsai@nycu.edu.tw. AD - School of Medcine, National Yang Ming Chiao Tung University, Taipei, Taiwan. AD - National Yang Ming Chiao Tung University Institute of Public Health, Taipei City, Taiwan. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260722 PL - England TA - Br J Ophthalmol JT - The British journal of ophthalmology JID - 0421041 RN - 0 (Mydriatics) SB - IM MH - Humans MH - *Myopia/diagnosis/physiopathology MH - Cross-Sectional Studies MH - Child, Preschool MH - Female MH - *Refraction, Ocular/physiology MH - Male MH - Child MH - *Vision Screening/methods MH - *Visual Acuity/physiology MH - *Vision Tests/methods MH - *Mydriatics/administration & dosage MH - Surveys and Questionnaires MH - Risk Factors OTO - NOTNLM OT - Epidemiology OT - Optics and Refraction COIS- Competing interests: None declared. EDAT- 2026/01/14 00:37 MHDA- 2026/07/23 05:36 CRDT- 2026/01/13 21:22 PHST- 2025/06/07 00:00 [received] PHST- 2025/12/31 00:00 [accepted] PHST- 2026/07/23 05:36 [medline] PHST- 2026/01/14 00:37 [pubmed] PHST- 2026/01/13 21:22 [entrez] AID - bjo-2025-328039 [pii] AID - 10.1136/bjo-2025-328039 [doi] PST - epublish SO - Br J Ophthalmol. 2026 Jul 22;110(8):922-928. doi: 10.1136/bjo-2025-328039. PMID- 41529206 OWN - NLM STAT- Publisher LR - 20260113 IS - 2047-4881 (Electronic) IS - 2047-4873 (Linking) DP - 2026 Jan 13 TI - The role of physical activity in an obesogenic environment for cardiovascular risk reduction across the lifespan. A Scientific Statement of the European Association of Preventive Cardiology of the ESC. LID - zwag033 [pii] LID - 10.1093/eurjpc/zwag033 [doi] AB - The rising prevalence of obesity poses an increasing burden on individuals, health care systems, and society. Obesity is the main risk factor for several cardiovascular diseases (CVD). Physical activity (PA) may help to reduce the risk for CVD across the lifespan independent of obesity. The obesogenic and built environment can influence obesity and PA. The primary objective of this scientific statement is to underscore the role of obesity as a risk factor for CVD and to explore how PA can be leveraged to mitigate CVD risk. A novel aspect is the examination of how environmental factors influence the feasibility and implementation of current PA guidelines. Rather than focusing exclusively on a specific age group, this scientific statement investigates how environmental determinants may affect the implementation of increasing PA throughout the lifespan by focusing on three age groups: children and adolescents (<18 years), adults (18-64 years), and older adults (>/=65 years). Furthermore, this scientific statement analyses the association of the built environment on PA behaviour by conducting a scoping literature review to identify age-specific evidence regarding the relation of the built environment on PA across the lifespan. This review highlights potentially effective strategies to reduce CVD risk within the context of the built environment and provides practical implications for healthcare professionals and policymakers to increase PA behaviour on an individual and societal level. Altogether, the present work raises awareness of the broader challenges posed by obesity and advocates for PA as a key strategy to improve public health outcomes. CI - (c) The Author(s) 2026. Published by Oxford University Press on behalf of the European Society of Cardiology. FAU - Siegrist, Monika AU - Siegrist M AUID- ORCID: 0000-0001-9357-5185 AD - Department for Preventive Sports Medicine and Sports Cardiology, TUM School of Medicine and Health, TUM University Hospital, Technical University of Munich, Munich, Germany. FAU - Bakker, Esmee A AU - Bakker EA AUID- ORCID: 0000-0003-3899-471X AD - Department of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain. AD - Department of Primary and Community Care, Radboud university medical center, Nijmegen, Netherlands. FAU - Timmermans, Erik J AU - Timmermans EJ AUID- ORCID: 0000-0002-3414-7196 AD - Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. FAU - Lam, Thao Minh AU - Lam TM AD - Amsterdam University Medical Center, Location Vrije Universiteit, Epidemiology and Data Science, Amsterdam, Netherlands. AD - Amsterdam Public Health, Health Behaviours and Chronic Diseases, Amsterdam, the Netherlands; Upstream Team, Amsterdam UMC, VU University Amsterdam, Netherlands. FAU - Moholdt, Trine AU - Moholdt T AUID- ORCID: 0000-0003-1024-8088 AD - Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway. AD - Department of Women's Health, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway. FAU - Lochen, Maja-Lisa AU - Lochen ML AUID- ORCID: 0000-0002-8532-6573 AD - Department of Clinical Medicine, UiT The Arctic University of Norway, Tromso, Norway. AD - Department of Cardiology, University Hospital of North Norway, Tromso, Norway. AD - Department of Community Medicine, UiT The Arctic University of Norway, Tromso, Norway. FAU - Hanssen, Henner AU - Hanssen H AUID- ORCID: 0000-0001-5501-4205 AD - Department of Sport, Exercise and Health, Sports and Exercise Medicine, University of Basel, Basel, Switzerland. FAU - Dalakoti, Mayank AU - Dalakoti M AUID- ORCID: 0000-0002-7091-7880 AD - Department of Cardiology, National University Heart Centre, Singapore. AD - Cardiovascular Metabolic Translational Research Program, National University of Singapore, Singapore. AD - British Heart Foundation Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, United Kingdom. FAU - Lakerveld, Jeroen AU - Lakerveld J AUID- ORCID: 0000-0002-8551-6748 AD - Amsterdam University Medical Center, Location Vrije Universiteit, Epidemiology and Data Science, Amsterdam, Netherlands. AD - Global Geo Health Data Center, University Medical Center Utrecht & Utrecht University, Utrecht, Netherlands. FAU - Vaartjes, Ilonca AU - Vaartjes I AUID- ORCID: 0000-0002-9951-5164 AD - Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands. FAU - Marques-Vidal, Pedro AU - Marques-Vidal P AUID- ORCID: 0000-0002-4548-8500 AD - Department of Medicine, Internal Medicine, Lausanne university hospital and University of Lausanne, Lausanne, Switzerland. FAU - Bahls, Martin AU - Bahls M AUID- ORCID: 0000-0002-2016-5852 AD - Department of Internal Medicine B, University Medicine Greifswald, Greifswald, Germany. AD - German Centre for Cardiovascular Research (DZHK), partner site Greifswald, Greifswald, Germany. LA - eng PT - Journal Article DEP - 20260113 PL - England TA - Eur J Prev Cardiol JT - European journal of preventive cardiology JID - 101564430 SB - IM OTO - NOTNLM OT - Adults OT - Built environment OT - Children OT - Exercise OT - Lifestyle OT - Obesity OT - Older adults OT - Physical activity OT - Prevention OT - Scoping review EDAT- 2026/01/13 19:39 MHDA- 2026/01/13 19:39 CRDT- 2026/01/13 15:53 PHST- 2025/11/05 00:00 [received] PHST- 2025/12/27 00:00 [revised] PHST- 2026/01/13 19:39 [medline] PHST- 2026/01/13 19:39 [pubmed] PHST- 2026/01/13 15:53 [entrez] AID - 8424721 [pii] AID - 10.1093/eurjpc/zwag033 [doi] PST - aheadofprint SO - Eur J Prev Cardiol. 2026 Jan 13:zwag033. doi: 10.1093/eurjpc/zwag033. PMID- 41528779 OWN - NLM STAT- MEDLINE DCOM- 20260714 LR - 20260813 IS - 1461-7277 (Electronic) IS - 1359-1053 (Print) IS - 1359-1053 (Linking) VI - 31 IP - 9 DP - 2026 Aug TI - Is mindful screen time a resilience factor for screen-related experiences of psychological needs and well-being? PG - 3709-3726 LID - 10.1177/13591053251398259 [doi] AB - We examined the measurement of mindful screen time and whether it moderated links between screen-related psychological needs (satisfaction and frustration) and well-being. University students (N = 770, M(age) = 19.96) completed a questionnaire online. A unidimensional structure of mindful screen time had an adequate fit (CFI = 0.97, RMSEA = 0.08) and composite reliability (0.79). Correlations between mindful screen time and well-being (rs = |0.08-0.26|) showed evidence of validity based on relations to other variables. Path analysis indicated two of the eight moderated associations were statistically significant but counter to hypotheses: higher mindful screen time increased the negative influence of need frustration on negative affect and diminished the positive influence of need satisfaction on flourishing. Screen-related psychological need satisfaction and frustration were key factors influencing well-being. Effect sizes were small-to-moderate (R(2) = 0.21-0.48). Overall, we found that that mindful screen time is not a robust moderator. More research is needed to better understand the role of mindful screen time on well-being. FAU - Gunnell, Katie E AU - Gunnell KE AUID- ORCID: 0000-0002-8729-6486 AD - Carleton University, Ottawa, ON, Canada. FAU - Salmon, Mackenzie AU - Salmon M AD - Carleton University, Ottawa, ON, Canada. FAU - Yung, Jayson J AU - Yung JJ AD - Carleton University, Ottawa, ON, Canada. FAU - Liu, Yan AU - Liu Y AUID- ORCID: 0000-0003-3778-1325 AD - Carleton University, Ottawa, ON, Canada. FAU - Goldfield, Gary S AU - Goldfield GS AD - Carleton University, Ottawa, ON, Canada. AD - The Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260113 PL - England TA - J Health Psychol JT - Journal of health psychology JID - 9703616 SB - IM MH - Humans MH - Psychological Well-Being MH - Female MH - *Screen Time MH - Young Adult MH - Male MH - *Mindfulness MH - *Resilience, Psychological MH - Students/psychology MH - Surveys and Questionnaires MH - Adolescent MH - *Personal Satisfaction MH - Reproducibility of Results MH - Adult PMC - PMC13365308 OTO - NOTNLM OT - adolescents OT - mental health OT - self-determination theory OT - smartphone OT - social media OT - young adults COIS- Declaration of conflicting interestsDr. Goldfield reports a relationship with ongoing social media litigation efforts that includes: paid consulting or Advisory. The other authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2026/01/13 13:15 MHDA- 2026/07/14 14:01 PMCR- 2026/07/14 CRDT- 2026/01/13 11:53 PHST- 2026/07/14 14:01 [medline] PHST- 2026/01/13 13:15 [pubmed] PHST- 2026/01/13 11:53 [entrez] PHST- 2026/07/14 00:00 [pmc-release] AID - 10.1177_13591053251398259 [pii] AID - 10.1177/13591053251398259 [doi] PST - ppublish SO - J Health Psychol. 2026 Aug;31(9):3709-3726. doi: 10.1177/13591053251398259. Epub 2026 Jan 13. PMID- 41528595 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20261009 IS - 1573-4978 (Electronic) IS - 0301-4851 (Linking) VI - 53 IP - 1 DP - 2026 Jan 13 TI - Molecular signatures of hypertension in polycystic ovary syndrome: Endothelin-1 and CYP11A1 as biomarkers of vascular and metabolic dysfunction. PG - 284 LID - 10.1007/s11033-026-11436-3 [doi] AB - BACKGROUND: Polycystic Ovary Syndrome (PCOS) is a complex endocrine syndrome impacting women during their reproductive phase of life and is increasingly recognized for its association with cardiovascular comorbidities, particularly hypertension. Despite its clinical significance, the hypertensive PCOS (H-PCOS) remains poorly characterized at the molecular level. METHODS AND RESULTS: The current study aimed to investigate the gene expression profiles of Endothelin-1 (ET-1) and Cytochrome P450 family 11subfamilly A member 1(CYP11A1) to elucidate their potential roles in the vascular and metabolic disturbances observed in H-PCOS. A total of 69 Kurdish women aged 18 to 53 were enrolled and classified into three groups: PCOS without hypertension, hypertensive PCOS, and healthy controls. Using qRT-PCR, we measured gene expression levels and assessed serum gonadotropin hormones and lipid profiles. ROC analysis showed that ET-1 (AUC = 0.8667, p = 0.0003) and CYP11A1 (AUC = 0.7667, p = 0.009) had significant diagnostic value, while fold-change analysis revealed approximately 13.5-fold and 82-fold increases, respectively, in H-PCOS patients compared with controls and non-hypertensive PCOS, confirming a statistically robust upregulation of both genes. Gene expression levels and clinical measurements including body mass index (BMI), Luteinizing Hormone to Follicle-Stimulating Hormone (LH/FSH) ratio, and Mean Arterial Pressure (MAP) were strongly correlated. H-PCOS was clearly separated from other groups using receiver operating characteristic (ROC) analysis for ET-1, CYP11A1, BMI, and the Total Cholesterol to High Density Lipoprotein-Cholesterol (TC/HDL-C) ratio. CONCLUSION: These findings highlight that endocrine and vascular irregularities are key features of genetic profile of H-PCOS. ET-1 and CYP11A1 can be used as potential biomarkers to better guide H-PCOS diagnosis of hypertension and therapy. FAU - Hosein, Mohammed-Ridha AU - Hosein MR AD - Department of Medical Laboratory Technology, Erbil Technical Health and Medical College, Erbil Polytechnic University, Erbil, Iraq. FAU - Housein, Zjwan AU - Housein Z AUID- ORCID: 0000-0002-8219-1001 AD - Department of Medical Laboratory Technology, Erbil Technical Health and Medical College, Erbil Polytechnic University, Erbil, Iraq. zjwan.h@epu.edu.iq. LA - eng PT - Journal Article DEP - 20260113 PL - Netherlands TA - Mol Biol Rep JT - Molecular biology reports JID - 0403234 RN - 0 (Endothelin-1) RN - 0 (Biomarkers) RN - EC 1.14.15.6 (Cholesterol Side-Chain Cleavage Enzyme) SB - IM MH - Humans MH - Female MH - *Polycystic Ovary Syndrome/genetics/complications/metabolism MH - *Endothelin-1/genetics/metabolism MH - Biomarkers/blood/metabolism MH - Adult MH - *Hypertension/genetics/metabolism/complications MH - *Cholesterol Side-Chain Cleavage Enzyme/genetics/metabolism MH - Middle Aged MH - Young Adult MH - Adolescent MH - Case-Control Studies OTO - NOTNLM OT - Biomarkers OT - Cytochrome P-450 CYP11A1 OT - Endothelial dysfunction OT - Endothelin-1 OT - Hypertension OT - Polycystic ovary syndrome COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/01/13 13:15 MHDA- 2026/06/27 06:47 CRDT- 2026/01/13 11:20 PHST- 2025/10/12 00:00 [received] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/06/27 06:47 [medline] PHST- 2026/01/13 13:15 [pubmed] PHST- 2026/01/13 11:20 [entrez] AID - 10.1007/s11033-026-11436-3 [pii] AID - 10.1007/s11033-026-11436-3 [doi] PST - epublish SO - Mol Biol Rep. 2026 Jan 13;53(1):284. doi: 10.1007/s11033-026-11436-3. PMID- 41528475 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1432-1084 (Electronic) IS - 0938-7994 (Print) IS - 0938-7994 (Linking) VI - 36 IP - 6 DP - 2026 Jun TI - Deep learning-based automatic measurement of the femoral head ossification center in healthy Korean children: development of a novel radiographic growth chart. PG - 4989-4999 LID - 10.1007/s00330-025-12263-z [doi] AB - OBJECTIVES: To develop and validate a deep learning (DL)-based algorithm for automated measurement of femoral head ossification center (FHOC) size and establish AI-derived growth charts. MATERIALS AND METHODS: This retrospective study included 1705 healthy Korean children (mean age, 5.1 +/- 3.3 years; 841 females, 864 males) with anteroposterior pelvic radiographs (2018-2024). A three-stage DL algorithm (region-of-interest detection, FHOC segmentation, landmark-based size computation) was used to automatically measure FHOC size. Agreement with radiologist measurements was evaluated using concordance correlation coefficient (CCC), Pearson correlation coefficient (r), mean absolute error (MAE), root mean square error (RMSE), and Bland-Altman analyses, supplemented by paired t-test and Fisher's Z-test. AI measurements were used to create FHOC growth charts via quantile polynomial regression, with predictive accuracy assessed by adjusted R(2), MAE, and RMSE. RESULTS: AI-derived FHOC size measurements showed close agreement with radiologist measurements, with mean differences within +/-0.5 mm and 95% limits of agreement within +/-3 mm in age-stratified analyses, and overall agreement was further supported by high CCC, r, and consistently low error metrics. Growth curves based on AI measurements demonstrated strong predictive accuracy (adjusted R(2) = 0.927 for females; 0.934 for males), with low errors across age groups (females: MAE 1.77-2.98 mm, RMSE 2.28-3.54 mm; males: MAE 1.60-3.01 mm, RMSE 2.00-4.10 mm). Reference percentiles (5th-95th) were established, providing standardized FHOC size ranges for clinical application. CONCLUSION: Our DL-based approach provides precise and reproducible FHOC size measurement, offering a robust reference for standardized growth assessment and early pediatric hip joint evaluation. KEY POINTS: QuestionThe timing of FHOC appearance is an important radiographic indicator; however, manual measurement is subjective, and studies on age-specific changes remain limited. FindingsA DL-based algorithm achieved high agreement with expert measurements, and age-based regression reliably predicted FHOC size in children. Clinical relevanceAI-derived FHOC growth charts may provide objective, standardized references for pediatric hip joint development, potentially enabling earlier detection of growth abnormalities and improving diagnostic consistency in clinical practice. CI - (c) 2025. The Author(s). FAU - Lee, Byoung-Dai AU - Lee BD AD - Department of Computer Science, Graduate School, Kyonggi University, Suwon-si, Republic of Korea. FAU - Moon, Ki-Ryum AU - Moon KR AD - Department of Computer Science, Graduate School, Kyonggi University, Suwon-si, Republic of Korea. FAU - Kim, Jin Young AU - Kim JY AD - Department of Radiology, Keimyung University Dongsan Hospital, Daegu, Republic of Korea. FAU - Lee, Mu Sook AU - Lee MS AUID- ORCID: 0000-0002-0382-5564 AD - Department of Radiology, Keimyung University Dongsan Hospital, Daegu, Republic of Korea. musukilee@kmu.ac.kr. LA - eng GR - NRF-2022R1A2C1007169/National Research Foundation of Korea/ GR - RS-2020-NR049579/National Research Foundation of Korea/ PT - Journal Article DEP - 20260113 PL - Germany TA - Eur Radiol JT - European radiology JID - 9114774 SB - IM MH - Humans MH - Female MH - Male MH - Child, Preschool MH - *Deep Learning MH - Republic of Korea MH - Retrospective Studies MH - *Growth Charts MH - Child MH - *Femur Head/diagnostic imaging/growth & development MH - Algorithms MH - *Osteogenesis/physiology MH - Reference Values MH - Infant MH - Radiography/methods MH - Reproducibility of Results PMC - PMC13212369 OTO - NOTNLM OT - Artificial intelligence OT - Child development OT - Femur head OT - Growth charts OT - Radiography COIS- Compliance with ethical standards. Guarantor: The scientific guarantor of this publication is Mu Sook Lee. Conflict of interest: The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. Statistics and biometry: All of the authors have significant statistical expertise. Informed consent: Written informed consent was waived by the Institutional Review Board due to the retrospective nature of the study and use of de-identified, pre-existing clinical data. Ethical approval: The Institutional Review Board of Keimyung University Dongsan Medical Center approved this retrospective study (IRB No. DSM-2022-08-007). All methods were performed in accordance with the ethical standards of the Helsinki Declaration. Study subjects or cohorts overlap: None of the study subjects or cohorts has been previously reported. Methodology: Retrospective Observational Performed at one institution EDAT- 2026/01/13 13:15 MHDA- 2026/05/27 06:34 PMCR- 2026/01/13 CRDT- 2026/01/13 11:14 PHST- 2025/05/13 00:00 [received] PHST- 2025/12/07 00:00 [accepted] PHST- 2025/11/29 00:00 [revised] PHST- 2026/05/27 06:34 [medline] PHST- 2026/01/13 13:15 [pubmed] PHST- 2026/01/13 11:14 [entrez] PHST- 2026/01/13 00:00 [pmc-release] AID - 10.1007/s00330-025-12263-z [pii] AID - 12263 [pii] AID - 10.1007/s00330-025-12263-z [doi] PST - ppublish SO - Eur Radiol. 2026 Jun;36(6):4989-4999. doi: 10.1007/s00330-025-12263-z. Epub 2026 Jan 13. PMID- 41528319 OWN - NLM STAT- MEDLINE DCOM- 20260526 LR - 20260909 IS - 1536-3732 (Electronic) IS - 1049-2275 (Linking) VI - 37 IP - 5 DP - 2026 May 1 TI - Craniometrics in Metopic Craniosynostosis: A Review of Craniometric Parameters and the Emergence of Machine Learning Models. PG - 1024-1031 LID - 10.1097/SCS.0000000000012342 [doi] AB - BACKGROUND: Metopic craniosynostosis (MCS) is defined by premature fusion of the metopic suture, resulting in trigonocephaly and potential neurodevelopmental implications. Advances in diagnosis and treatment over the past 2 decades have improved landmarking and evaluation using objective imaging metrics. While computed tomography (CT) remains the diagnostic standard, concerns over pediatric radiation exposure have increased reliance on 3D photogrammetry. Both modalities, however, have limitations in capturing the full range of craniofacial dysmorphology. This systematic review evaluates current craniometric parameters and emerging machine learning (ML) models used to assess MCS morphology. METHODS: A systematic search of PubMed and Google Scholar, following PRISMA guidelines, identified English-language studies reporting imaging-based craniometric or ML methods for MCS assessment. Extracted outcomes included severity metrics, roles in surgical decision-making, and postoperative evaluation. Due to study heterogeneity, findings were descriptively synthesized. RESULTS: Fifty-eight studies involving 9068 patients met the inclusion criteria. A total of 2425 (26.7%) had MCS. CT was the most common imaging modality (78.4%), followed by 3D (15.7%) and 2D (7.8%) photogrammetry. Over 100 craniometric parameters were reported, most frequently the interfrontal angle (IFA) and endocranial bifrontal angle (EBA). Eighteen studies (31%) utilized ML models introducing indices such as the Metopic Severity Score, Cranial Morphology Deviation score, and Head Shape Anomaly index, which showed high diagnostic accuracy for severity grading and outcome prediction. CONCLUSIONS: CT-based metrics remain standard, but ML models using advanced imaging offer radiation-free, objective, and reproducible assessments. Future efforts should emphasize multicenter data sharing, standardized variables, longitudinal imaging, and integration of genotypic and neuropsychological data. CI - Copyright (c) 2026 by Mutaz B. Habal, MD. FAU - Le, David M AU - Le DM AUID- ORCID: 0009-0004-8412-2546 AD - University of Colorado School of Medicine. AD - Department of Surgery, University of Colorado Anschutz Medical Campus. FAU - Hoffman, Gavin R AU - Hoffman GR AD - University of Colorado School of Medicine. FAU - Le, Thalia AU - Le T AD - Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Colorado Anschutz Medical Campus. FAU - Elkhill, Connor AU - Elkhill C AD - Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus. AD - Department of Pediatric Plastic and Reconstructive Surgery, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO. FAU - Porras, Antonio AU - Porras A AD - Department of Biostatistics and Informatics, Colorado School of Public Health, University of Colorado Anschutz Medical Campus. AD - Department of Pediatric Plastic and Reconstructive Surgery, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO. FAU - French, Brooke AU - French B AD - Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Colorado Anschutz Medical Campus. AD - Department of Pediatric Plastic and Reconstructive Surgery, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO. FAU - Yu, Jason W AU - Yu JW AD - Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Colorado Anschutz Medical Campus. AD - Department of Pediatric Plastic and Reconstructive Surgery, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO. FAU - Nguyen, Phuong D AU - Nguyen PD AD - Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Colorado Anschutz Medical Campus. AD - Department of Pediatric Plastic and Reconstructive Surgery, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO. FAU - Mathes, David W AU - Mathes DW AD - Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Colorado Anschutz Medical Campus. FAU - Khechoyan, David AU - Khechoyan D AD - Department of Surgery, Division of Plastic and Reconstructive Surgery, University of Colorado Anschutz Medical Campus. AD - Department of Pediatric Plastic and Reconstructive Surgery, Children's Hospital Colorado, University of Colorado Anschutz Medical Campus, Aurora, CO. LA - eng PT - Journal Article PT - Systematic Review DEP - 20260113 PL - United States TA - J Craniofac Surg JT - The Journal of craniofacial surgery JID - 9010410 SB - IM MH - *Craniosynostoses/diagnostic imaging/surgery MH - Humans MH - *Machine Learning MH - *Cephalometry/methods MH - Tomography, X-Ray Computed MH - Imaging, Three-Dimensional MH - Photogrammetry OTO - NOTNLM OT - 3D photogrammetry OT - craniometrics OT - machine learning OT - metopic craniosynostosis COIS- The authors report no conflicts of interest. EDAT- 2026/01/13 13:16 MHDA- 2026/05/26 23:33 CRDT- 2026/01/13 10:43 PHST- 2025/10/16 00:00 [received] PHST- 2025/12/04 00:00 [accepted] PHST- 2026/05/26 23:33 [medline] PHST- 2026/01/13 13:16 [pubmed] PHST- 2026/01/13 10:43 [entrez] AID - 00001665-990000000-03625 [pii] AID - 10.1097/SCS.0000000000012342 [doi] PST - ppublish SO - J Craniofac Surg. 2026 May 1;37(5):1024-1031. doi: 10.1097/SCS.0000000000012342. Epub 2026 Jan 13. PMID- 41527000 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260210 LR - 20260212 IS - 2055-5784 (Print) IS - 2055-5784 (Electronic) IS - 2055-5784 (Linking) VI - 12 IP - 1 DP - 2026 Jan 13 TI - Training caregivers to screen for relapse among children who have recovered from severe acute malnutrition: study protocol for a feasibility trial. PG - 22 LID - 10.1186/s40814-025-01752-z [doi] LID - 22 AB - BACKGROUND: Children with severe acute malnutrition (SAM) have a high risk of mortality and morbidity. After recovery from an initial episode of SAM, the risk of relapse can be high, although estimates vary across settings. Post-recovery surveillance for relapsed SAM in Burkina Faso consists of monthly clinic-based follow-up visits. However, adherence to the follow-up schedule can be variable, and children with missed surveillance visits may have delayed diagnoses of relapse. Here, we describe the protocol for a feasibility trial design to provide preliminary evidence to support the training of caregivers to screen for relapsed acute malnutrition using mid-upper arm circumference (MUAC) screening at home. METHODS: This feasibility trial will enroll 200 caregiver-child dyads in which the child has recovered in the past month from an episode of SAM in Boromo, Burkina Faso. Eligible children had an initial episode of SAM that they recovered from per Burkinabe guidelines (weight-for-height Z-score, WHZ >/= -2 and/or MUAC >/= 12.5 cm, depending on the admission criteria). Caregiver-child dyads are randomized to either weekly screening using a standard MUAC tape plus standard of care follow-up or standard of care alone, which consists of monthly clinic-based screening for relapse for 3 months. Caregiver-child dyads are followed for 6 months. Primary feasibility endpoints include acceptability, time for training, enrollment potential and refusals, adherence to the follow-up protocol, and adherence to the screening protocol. Clinical endpoints, measured to inform the design of a full-scale trial, include the proportion of children relapsing, anthropometric measurements at 6 months, hospitalization, and vital status. DISCUSSION: This feasibility trial will generate data to support the development and full-scale testing of an intervention to train caregivers to screen for relapsed acute malnutrition using MUAC. TRIAL REGISTRATION: This trial is registered at clinicaltrials.gov (NCT05932992), first posted 27 June 2023. CI - (c) 2026. The Author(s). FAU - Dah, Clarisse AU - Dah C AD - Centre de Recherche en Sante de Nouna, Nouna, Burkina Faso. FAU - Kimfuema, Aimee AU - Kimfuema A AD - Francis I Proctor Foundation, University of California, San Francisco, USA. FAU - Bountogo, Mamadou AU - Bountogo M AD - Centre de Recherche en Sante de Nouna, Nouna, Burkina Faso. FAU - Zerbo, Fanta AU - Zerbo F AD - Centre de Recherche en Sante de Nouna, Nouna, Burkina Faso. FAU - Ouedraogo, Moussa AU - Ouedraogo M AD - Centre de Recherche en Sante de Nouna, Nouna, Burkina Faso. FAU - Kouanda, Idrissa AU - Kouanda I AD - Francis I Proctor Foundation, University of California, San Francisco, USA. FAU - Fetterman, Ian AU - Fetterman I AD - Francis I Proctor Foundation, University of California, San Francisco, USA. FAU - Arnold, Benjamin F AU - Arnold BF AD - Francis I Proctor Foundation, University of California, San Francisco, USA. AD - Department of Ophthalmology, University of California, San Francisco, USA. FAU - Lebas, Elodie AU - Lebas E AD - Francis I Proctor Foundation, University of California, San Francisco, USA. FAU - Sie, Ali AU - Sie A AD - Centre de Recherche en Sante de Nouna, Nouna, Burkina Faso. AD - Francis I Proctor Foundation, University of California, San Francisco, USA. FAU - Oldenburg, Catherine E AU - Oldenburg CE AD - Francis I Proctor Foundation, University of California, San Francisco, USA. catherine.oldenburg@ucsf.edu. AD - Department of Ophthalmology, University of California, San Francisco, USA. catherine.oldenburg@ucsf.edu. AD - Department of Epidemiology & Biostatistics, University of California, San Francisco, USA. catherine.oldenburg@ucsf.edu. LA - eng SI - ClinicalTrials.gov/NCT05932992 PT - Journal Article DEP - 20260113 PL - England TA - Pilot Feasibility Stud JT - Pilot and feasibility studies JID - 101676536 PMC - PMC12888166 OTO - NOTNLM OT - Mid-upper arm circumference OT - Relapse OT - Screening OT - Severe acute malnutrition OT - Wasting COIS- Declarations. Ethics approval and consent to participate: The study was reviewed and approved by the Institutional Review Board at the University of California, San Francisco (Protocol 23-38829) and the Comite d'Ethique pour la Recherche en Sante in Ouagadougou, Burkina Faso (Protocol 2023-09-219). Written informed consent is obtained from the caregiver for both their participation and the participation of their child. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/13 00:24 MHDA- 2026/01/13 00:25 PMCR- 2026/01/13 CRDT- 2026/01/12 23:58 PHST- 2024/02/19 00:00 [received] PHST- 2025/12/03 00:00 [accepted] PHST- 2026/01/13 00:25 [medline] PHST- 2026/01/13 00:24 [pubmed] PHST- 2026/01/12 23:58 [entrez] PHST- 2026/01/13 00:00 [pmc-release] AID - 10.1186/s40814-025-01752-z [pii] AID - 1752 [pii] AID - 10.1186/s40814-025-01752-z [doi] PST - epublish SO - Pilot Feasibility Stud. 2026 Jan 13;12(1):22. doi: 10.1186/s40814-025-01752-z. PMID- 41526955 OWN - NLM STAT- MEDLINE DCOM- 20260628 LR - 20260721 IS - 1472-6874 (Electronic) IS - 1472-6874 (Linking) VI - 26 IP - 1 DP - 2026 Jan 13 TI - A relationship study of factors associated with emotional eating in women in Turkiye: body mass index, premenstrual syndrome, eating behavior, and quality of life. PG - 85 LID - 10.1186/s12905-026-04270-z [doi] LID - 85 AB - BACKGROUND: Obesity and premenstrual syndrome (PMS) are associated with hormonal and psychosocial factors that affect emotional appetite and eating behaviors in women. In a sample of Turkish women, evidence regarding the relationships between body mass index (BMI), PMS symptoms, eating behaviors, quality of life, and emotional appetite is limited. This study was conducted to examine the relationships between emotional eating and BMI, PMS, eating behaviors, and quality of life among women in Turkey and to assess the relative contributions of these factors to emotional eating. METHODS: This cross-sectional study, conducted online in Turkiye between April 1 and May 1, 2025, included 450 women aged 18-49 years. Data were collected using snowball sampling with validated and reliable scales for PMS, emotional appetite, eating behavior, and PMS-specific quality of life. Four-block hierarchical regression analysis (IBM SPSS 27.0) was performed to assess the contributions of BMI, PMS subscales, eating behaviors, and quality of life, respectively, with a significance level of p < 0.05. RESULTS: Most participants were single (63.8%), had a bachelor's degree (66.4%), and had regular menstrual cycles (88.4%). Depressive mood and fatigue had the highest mean scores on the PSAS subscales. A positive correlation was found between emotional appetite and BMI (r = 0.386), PMS appetite changes (r = 0.277), and emotional undereating (r = 0.439); a strong negative correlation was found with emotional overeating (r = - 0.641). In hierarchical regression analysis, emotional overeating emerged as the strongest predictor of emotional appetite (beta = -0.523). BMI and PMS-induced appetite changes showed their explanatory effects more prominently in the earlier model steps. The final model explained 51.3% of the variance in emotional appetite (Adjusted R(2) = 0.513). CONCLUSIONS: The findings support a multidimensional perspective on premenstrual distress, revealing significant links between BMI, emotional appetite, and PMS symptom severity. Specifically, emotional overeating and undereating emerged as strong behavioral predictors, while hierarchical models confirmed that these factors collectively explain significant incremental variance in symptom burden. These results underscore the need for integrated interventions that address the biological (e.g., weight status), psychological (e.g., affective symptoms), and behavioral (e.g., emotion-driven eating) dimensions underlying this relationship. FAU - Ozcanarslan, Neslihan AU - Ozcanarslan N AUID- ORCID: 0000-0002-3613-6319 AD - Department of Public Health Nursing, Faculty of Health Sciences, Toros University, Mersin, 33140, Turkiye. neslihan.ozcanarslan@toros.edu.tr. FAU - Ozpak Akkus, Ozlem AU - Ozpak Akkus O AUID- ORCID: 0000-0002-1471-8000 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Toros University, Mersin, Turkiye. LA - eng PT - Journal Article DEP - 20260113 PL - England TA - BMC Womens Health JT - BMC women's health JID - 101088690 SB - IM MH - Humans MH - Female MH - *Quality of Life/psychology MH - Adult MH - *Emotional Eating/psychology MH - *Premenstrual Syndrome/psychology/epidemiology MH - *Body Mass Index MH - Cross-Sectional Studies MH - Middle Aged MH - Young Adult MH - Adolescent MH - *Feeding Behavior/psychology MH - Turkey/epidemiology MH - Surveys and Questionnaires MH - Obesity/psychology MH - Emotions PMC - PMC12888315 OTO - NOTNLM OT - Appetite OT - Body mass index OT - Eating behavior OT - Emotional eating OT - Premenstrual syndrome OT - Quality of life COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical principles of the Declaration of Helsinki. This study was approved by the Toros University Scientific Research and Publication Ethics Committee (Protocol No: 51, Approval Date: March 23, 2025). The informed consent process was conducted via an online survey platform (Google Forms). At the beginning of the survey, participants were presented with a comprehensive information text about the purpose of the study, the expected duration, risks and benefits, the anonymity and confidentiality of the data, the fact that participation was entirely voluntary, and the right to withdraw at any time. To confirm that they had read and agreed to this information, they were required to check a box indicating 'I agree' before continuing with the survey. Only participants who checked this box were able to access the survey questions. This method is a standard electronic informed consent procedure approved by the ethics committee. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/13 00:25 MHDA- 2026/06/28 13:04 PMCR- 2026/01/13 CRDT- 2026/01/12 23:54 PHST- 2025/11/10 00:00 [received] PHST- 2026/01/06 00:00 [accepted] PHST- 2026/06/28 13:04 [medline] PHST- 2026/01/13 00:25 [pubmed] PHST- 2026/01/12 23:54 [entrez] PHST- 2026/01/13 00:00 [pmc-release] AID - 10.1186/s12905-026-04270-z [pii] AID - 4270 [pii] AID - 10.1186/s12905-026-04270-z [doi] PST - epublish SO - BMC Womens Health. 2026 Jan 13;26(1):85. doi: 10.1186/s12905-026-04270-z. PMID- 41526907 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1475-2875 (Electronic) IS - 1475-2875 (Linking) VI - 25 IP - 1 DP - 2026 Jan 12 TI - The Malaria Vaccine Implementation Programme study area in Ghana: results of a household survey prior to the introduction of the RTS,S/AS01 vaccine. PG - 69 LID - 10.1186/s12936-025-05778-9 [doi] LID - 69 AB - BACKGROUND: In 2019, the RTS,S/AS01(E) malaria vaccine (RTS,S) was introduced into Ghana's routine health system as part of the Malaria Vaccine Implementation Programme (MVIP). Household surveys were conducted prior to vaccine introduction and approximately 18 and 30 months post-introduction. We present a description of the area in Ghana based on the baseline household survey including malaria prevalence, malnutrition, wealth, insecticide-treated net (ITN) coverage, other health interventions (deworming, Vitamin A supplementation (VAS)), coverage of Expanded Programme on Immunization (EPI) vaccines, and health-seeking behaviour for febrile children. METHODS: The baseline household survey was conducted between 25 February and 18 March 2019 in a representative sample of 6778 households across 66 districts (33 in each of the implementing and comparator areas) in Ghana. Caregivers of children aged 5-48 months were interviewed. For each child, vaccination details were transcribed from the maternal and child health record book, and we measured the mid-upper arm circumference and obtained a malaria Rapid Diagnostic Test (RDT). Survey-weighted coverage estimates were obtained using standard survey methods. Survey Poisson regression was used to estimate prevalence ratios. RESULTS: Overall, 7768 children were included in the study, and 21% (95% CI 18-23) tested positive for malaria parasitemia by RDT. About 87%, 95%CI (85-89) of all households owned at least one ITN, and 62%, 95%CI (59-64) of children aged 5-48 months slept under an insecticide-treated net (ITN) the night before the survey. Additionally, 22%, 95%CI (21-24) of children reported having fever in the two weeks preceding the survey; among those with reported fever, 72%, 95%CI (69-74) sought advice or treatment, 40%, 95%CI (37-44) were tested for malaria, and 42%, 95%CI (39-46) of those with fever took an antimalarial drug. Additionally, 17%, 95%CI (16-19) had a mid-upper arm circumference (MUAC) 90%. Indicators in comparison and implementation areas were comparable. CONCLUSIONS: The pilot implementation and evaluation of the RTS,S malaria vaccine in Ghana was conducted in an area with substantial malaria transmission and illness, modest health-seeking behaviour and ITN use, and good EPI vaccine coverage. This study has established the baseline comparability between implementation and comparator areas, which serves as the foundation for future feasibility assessments. CI - (c) 2026. The Author(s). FAU - Welaga, Paul AU - Welaga P AD - University of Technology and Applied Sciences, P. O. Box 24, Navrongo, Ghana. pwelaga@yahoo.com. AD - Research and Development Division, Ghana Health Service, Navrongo Health Research Centre, Navrongo, Ghana. pwelaga@yahoo.com. FAU - Gyan, Thomas AU - Gyan T AD - Research and Development Division, Ghana Health Service, Kintampo Health Research Centre, Kintampo North Municipality, Bono East Region, Ghana. FAU - Koram, Kwadwo AU - Koram K AD - Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana. FAU - Hodgson, Abraham AU - Hodgson A AD - Research and Development Division, Ghana Health Service, Accra, Ghana. FAU - Odei-Lartey, Eliezer AU - Odei-Lartey E AD - Research and Development Division, Ghana Health Service, Kintampo Health Research Centre, Kintampo North Municipality, Bono East Region, Ghana. FAU - Agbokey, Francis AU - Agbokey F AD - Research and Development Division, Ghana Health Service, Kintampo Health Research Centre, Kintampo North Municipality, Bono East Region, Ghana. FAU - Gyaase, Stephaney AU - Gyaase S AD - Research and Development Division, Ghana Health Service, Kintampo Health Research Centre, Kintampo North Municipality, Bono East Region, Ghana. FAU - Awini, Elizabeth AU - Awini E AD - Research and Development Division, Ghana Health Service, Dodowa Health Research Centre, Greater Accra Region, Dodowa, Ghana. FAU - Adu-Gyasi, Dennis AU - Adu-Gyasi D AD - Research and Development Division, Ghana Health Service, Kintampo Health Research Centre, Kintampo North Municipality, Bono East Region, Ghana. FAU - Amenuvegbe, Gregory K AU - Amenuvegbe GK AD - FN Binka School of Public Health, University of Health and Allied Sciences, Ho, Ghana. FAU - Dadzie, Dora AU - Dadzie D AD - School of Public Health, University of Ghana, Accra, Ghana. FAU - Adam, Abdul-Razak AU - Adam AR AD - Ghana Health Service, Bono Regional Health Directorate, Sunyani, Ghana. FAU - Hammond, John AU - Hammond J AD - Ghana Health Service, Central Regional Health Directorate, Cape Coast, Ghana. FAU - Sarfo, Augustine AU - Sarfo A AD - Research and Development Division, Ghana Health Service, Kintampo Health Research Centre, Kintampo North Municipality, Bono East Region, Ghana. FAU - Nuhu, Abdul-Razak AU - Nuhu AR AD - Research and Development Division, Ghana Health Service, Kintampo Health Research Centre, Kintampo North Municipality, Bono East Region, Ghana. FAU - Peprah, Peter Takyi AU - Peprah PT AD - Ghana Statistical Service, Accra, Ghana. FAU - Twumwaa, Lucy AU - Twumwaa L AD - Ghana Statistical Service, Accra, Ghana. FAU - Boateng, Emmanuel AU - Boateng E AD - Ghana Statistical Service, Accra, Ghana. FAU - Snell, Paul AU - Snell P AD - London School of Hygiene and Tropical Medicine, London, UK. FAU - Fogelson, Ari AU - Fogelson A AD - Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK. FAU - Okine, Rafiq N A AU - Okine RNA AD - Global Malaria Programme, World Health Organization, Geneva, Switzerland. FAU - Hamel, Mary J AU - Hamel MJ AD - Department of Immunizations, Vaccines, and Biologicals, World Health Organization, Geneva, Switzerland. FAU - Milligan, Paul AU - Milligan P AD - Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, UK. FAU - Moore, Kerryn A AU - Moore KA AD - London School of Hygiene and Tropical Medicine, London, UK. FAU - Binka, Fred N AU - Binka FN AD - FN Binka School of Public Health, University of Health and Allied Sciences, Ho, Ghana. FAU - Afari, Edwin A AU - Afari EA AD - School of Public Health, University of Ghana, Accra, Ghana. FAU - Asante, Kwaku Poku AU - Asante KP AD - Research and Development Division, Ghana Health Service, Kintampo Health Research Centre, Kintampo North Municipality, Bono East Region, Ghana. AD - London School of Hygiene and Tropical Medicine, London, UK. LA - eng GR - 001/WHO_/World Health Organization/International PT - Journal Article DEP - 20260112 PL - England TA - Malar J JT - Malaria journal JID - 101139802 RN - 0 (Malaria Vaccines) RN - 0 (Vaccines, Synthetic) RN - 0 (RTS,S-AS01 vaccine) SB - IM MH - Ghana/epidemiology MH - Humans MH - *Malaria Vaccines/administration & dosage MH - Child, Preschool MH - Male MH - Female MH - Infant MH - *Immunization Programs/statistics & numerical data MH - Vaccines, Synthetic/administration & dosage MH - Family Characteristics MH - Prevalence MH - *Malaria/prevention & control/epidemiology MH - *Malaria, Falciparum/prevention & control/epidemiology PMC - PMC12862907 OTO - NOTNLM OT - Ghana OT - Health-seeking behaviours OT - Immunization OT - Malaria vaccine pilot evaluation COIS- Declarations. Ethics approval and consent to participate: The Ethics Review Committees of the Ghana Health Service (GHSERC) and the World Health Organization (WHOERC) approved the study. Written informed consent was obtained from each survey respondent before the interview. The research proposal, including the survey tools, consent forms, and the curriculum vitae of all the investigators, was submitted to the GHSERC and WHOERC for ethical clearance. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/13 00:25 MHDA- 2026/02/03 07:41 PMCR- 2026/01/12 CRDT- 2026/01/12 23:49 PHST- 2025/07/20 00:00 [received] PHST- 2025/12/29 00:00 [accepted] PHST- 2026/02/03 07:41 [medline] PHST- 2026/01/13 00:25 [pubmed] PHST- 2026/01/12 23:49 [entrez] PHST- 2026/01/12 00:00 [pmc-release] AID - 10.1186/s12936-025-05778-9 [pii] AID - 5778 [pii] AID - 10.1186/s12936-025-05778-9 [doi] PST - epublish SO - Malar J. 2026 Jan 12;25(1):69. doi: 10.1186/s12936-025-05778-9. PMID- 41526856 OWN - NLM STAT- MEDLINE DCOM- 20260602 LR - 20260706 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2026 Jan 13 TI - "Predictors of failed vaginal birth after cesarean and associated maternal and neonatal outcomes: a case control study". PG - 145 LID - 10.1186/s12884-025-08594-w [doi] LID - 145 AB - BACKGROUND: Vaginal Birth After Cesarean is a clinical measure that can reduce repeated cesarean deliveries, improve perinatal outcomes and shorten hospital stays. However, successful practice of Vaginal Birth After Cesarean remains restricted in the Middle East due to limited regional-specific guidelines. This study aimed to identify the predictors and maternal and neonatal outcomes of failed Vaginal Birth After Cesarean among a group of Middle Eastern women. METHODS: A retrospective case-control design was conducted between January 2023 and February 2024 across three hospitals in Oman. The case group involved failed Vaginal Birth After Cesarean requiring repeat cesarean, while the control group comprised successful Vaginal Birth After Cesarean. Descriptive and inferential statistics were used. Additionally, logistic regression analysis was conducted to identify significant predictors of failed vaginal birth after cesarean. RESULTS: Data of 364 participants were analyzed. The predictors of Vaginal Birth After Cesarean failure were high body mass index (32.66 +/- 7.53; p < .001), low parity (median = 1; p < .001), low cervical dilation (2 cm vs. 4 cm; p < .001), obstetric complications (42.6% vs. 29.2%; p = .010), and meconium-stained amniotic fluid (16.3% vs. 6.9%; p = .006). Postpartum hemorrhage (21.6% vs. 4.6%; p < .001), scar tenderness (11.5% vs. 0.5%; p < .001), and low APGAR scores (p < .001) were more common in the case group. CONCLUSIONS: The study findings advance the regional literature with critical information supporting the development of standardized Middle Eastern specific Vaginal Birth After Cesarean guidelines. Higher body mass index, lower parity, lower cervical dilation at admission, meconium-stained amniotic fluid, and obstetric complications are significant predictors of Vaginal Birth After Cesarean failure. A failed Vaginal Birth After Cesarean attempt may increase the risks of post-partum hemorrhage, scar tenderness, and lower APGAR scores. Future research may prioritize prospective multicenter studies across diverse regions of the Middle East to validate the Vaginal Birth After Cesarean predictive variables. CI - (c) 2026. The Author(s). FAU - Al Rashdia, Asila AU - Al Rashdia A AD - Maternal and Child Health Department, College of Nursing, Sultan Qaboos University, Al Khod 66, Muscat, 123, Oman. AD - Delivery Ward, Sultan Qaboos University Hospital, Muscat, Oman. FAU - Al Yazeedi, Basma AU - Al Yazeedi B AD - Maternal and Child Health Department, College of Nursing, Sultan Qaboos University, Al Khod 66, Muscat, 123, Oman. basma84@squ.edu.om. FAU - Al Hashmi, Iman AU - Al Hashmi I AD - Maternal and Child Health Department, College of Nursing, Sultan Qaboos University, Al Khod 66, Muscat, 123, Oman. FAU - Al Azri, Zeinab AU - Al Azri Z AD - Maternal and Child Health Department, College of Nursing, Sultan Qaboos University, Al Khod 66, Muscat, 123, Oman. LA - eng GR - RC/GRG/CON/M&C/24/112/Ministry of Higher Education, Research and Innovation/ PT - Journal Article DEP - 20260113 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Adult MH - Female MH - Humans MH - Infant, Newborn MH - Pregnancy MH - Case-Control Studies MH - Cesarean Section, Repeat/statistics & numerical data MH - Oman/epidemiology MH - Parity MH - Pregnancy Outcome MH - Retrospective Studies MH - Risk Factors MH - *Vaginal Birth after Cesarean/statistics & numerical data/adverse effects PMC - PMC12888156 OTO - NOTNLM OT - Cesarean section OT - Maternal outcomes OT - Neonatal outcomes OT - Oman OT - Trial of labor after cesarean OT - Vaginal birth after cesarean COIS- Declarations. Ethics approval and consent to participate: The researchers obtained ethical approvals from the Research and Ethics Committee at the College of Nursing in Sultan Qaboos University (CON/MSN/2024/5) and the Health Studies and Research Approval Committee at the Ministry of Health (MOH/CSR/24/28414), Oman. Due to the nature of the retrospective design of the study, informed consent was waived. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/13 00:25 MHDA- 2026/02/10 06:31 PMCR- 2026/01/13 CRDT- 2026/01/12 23:46 PHST- 2025/10/07 00:00 [received] PHST- 2025/12/12 00:00 [accepted] PHST- 2026/02/10 06:31 [medline] PHST- 2026/01/13 00:25 [pubmed] PHST- 2026/01/12 23:46 [entrez] PHST- 2026/01/13 00:00 [pmc-release] AID - 10.1186/s12884-025-08594-w [pii] AID - 8594 [pii] AID - 10.1186/s12884-025-08594-w [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2026 Jan 13;26(1):145. doi: 10.1186/s12884-025-08594-w. PMID- 41525344 OWN - NLM STAT- MEDLINE DCOM- 20260112 LR - 20260115 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 1 DP - 2026 TI - ACMTF-R: Supervised multi-omics data integration uncovering shared and distinct outcome-associated variation. PG - e0339650 LID - 10.1371/journal.pone.0339650 [doi] LID - e0339650 AB - The rapid growth of high-dimensional biological data has necessitated advanced data fusion techniques to integrate and interpret complex multi-omics and longitudinal datasets. Shared and unshared structure across such datasets can be identified in an unsupervised manner with Advanced Coupled Matrix and Tensor Factorization (ACMTF), but this cannot be related to an outcome. Conversely, N-way Partial Least Squares (NPLS) is supervised and captures outcome-associated variation but cannot identify shared and unshared structure. To bridge the gap between data exploration and prediction, we introduce ACMTF-Regression (ACMTF-R), an extension of ACMTF that incorporates a regression step, allowing for the simultaneous decomposition of multi-way data while explicitly capturing variation associated with a dependent variable. We present a detailed mathematical formulation of ACMTF-R, including its optimisation algorithm and implementation. Through extensive simulations, we systematically evaluate its ability to recover a small [Formula: see text]-related component shared between multiple blocks, its robustness to noise, and the impact of the tuning parameter ([Formula: see text]) which controls the balance between data exploration and outcome prediction. Our results demonstrate that ACMTF-R can robustly identify the [Formula: see text]-related component, correctly identifying outcome-associated shared and distinct variation, distinguishing it from existing approaches such as NPLS and ACMTF. The development of ACMTF-R was motivated by a real-world dataset investigating how maternal pre-pregnancy BMI affects the human milk microbiome, human milk metabolome, and infant faecal microbiome. Emerging evidence suggests that inter-generational transfer of maternal obesity may affect multiple omics layers, highlighting the need to identify outcome-associated variation. The applicability of ACMTF-R is therefore validated by applying it to this multi-omics dataset. ACMTF-R successfully identifies novel mother-infant relationships associated with maternal pre-pregnancy BMI, underscoring its utility in multi-omics research. Our findings establish ACMTF-R as a versatile tool for multi-way data fusion, offering new insights into complex biological systems by integrating common, local, and distinct variation in the context of a dependent variable. CI - Copyright: (c) 2026 van der Ploeg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - van der Ploeg, Geert Roelof AU - van der Ploeg GR AUID- ORCID: 0009-0007-5204-3386 AD - Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands. FAU - White, Fred T G AU - White FTG AUID- ORCID: 0000-0003-0434-6028 AD - Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands. FAU - Jakobsen, Rasmus Riemer AU - Jakobsen RR AD - Department of Food Science, University of Copenhagen, Rolighedsvej, Frederiksberg C, Denmark. FAU - Westerhuis, Johan A AU - Westerhuis JA AD - Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands. FAU - Heintz-Buschart, Anna AU - Heintz-Buschart A AUID- ORCID: 0000-0002-9780-1933 AD - Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands. FAU - Smilde, Age K AU - Smilde AK AD - Biosystems Data Analysis, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands. LA - eng PT - Journal Article DEP - 20260112 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Female MH - Humans MH - Pregnancy MH - Algorithms MH - Metabolomics/methods MH - Milk, Human/microbiology/metabolism MH - *Multiomics MH - Feces/microbiology MH - Infant PMC - PMC12795394 COIS- The authors have declared that no competing interests exist. EDAT- 2026/01/12 19:24 MHDA- 2026/01/12 19:25 PMCR- 2026/01/12 CRDT- 2026/01/12 13:46 PHST- 2025/09/04 00:00 [received] PHST- 2025/12/09 00:00 [accepted] PHST- 2026/01/12 19:25 [medline] PHST- 2026/01/12 19:24 [pubmed] PHST- 2026/01/12 13:46 [entrez] PHST- 2026/01/12 00:00 [pmc-release] AID - PONE-D-25-48000 [pii] AID - 10.1371/journal.pone.0339650 [doi] PST - epublish SO - PLoS One. 2026 Jan 12;21(1):e0339650. doi: 10.1371/journal.pone.0339650. eCollection 2026. PMID- 41523078 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260112 LR - 20260114 IS - 0976-4879 (Print) IS - 0975-7406 (Electronic) IS - 0975-7406 (Linking) VI - 17 IP - Suppl 4 DP - 2025 Dec TI - Oral Hygiene Neglect in Indian Teens and Young Adults Due to Depression Caused by Internet Addiction. PG - S3063-S3065 LID - 10.4103/jpbs.jpbs_1076_25 [doi] AB - BACKGROUND: Internet addiction is increasingly prevalent among adolescents and young adults, contributing to mental health issues and self-care neglect, including oral hygiene. AIM: To assess the correlation between internet addiction-induced depression and oral hygiene neglect among Indian youth. METHODS: A cross-sectional survey was conducted among 382 university students aged 17-25 using a validated online questionnaire. Data were analyzed using Chi-square tests. RESULTS: Significant associations were found between high screen time, depressive symptoms (P = 0.001), and reduced brushing frequency (P = 0.015). CONCLUSION: Internet addiction is linked to depression and neglect of oral hygiene in young adults. CI - Copyright: (c) 2025 Journal of Pharmacy and Bioallied Sciences. FAU - Pandey, Shreyansh AU - Pandey S AD - Manav Rachna Dental College, Faridabad, Haryana, India. FAU - Srivastava, Madhulika AU - Srivastava M AD - Department of Pediatric and Preventive Dentistry, Manav Rachna Dental College, Faridabad, Haryana, India. FAU - Bansal, Savita AU - Bansal S AD - Department of General Pathology, Manav Rachna Dental College, SDS, MRIIRS, Faridabad, Haryana, India. FAU - Goswami, Harsita AU - Goswami H AD - Manav Rachna Dental College, Faridabad, Haryana, India. FAU - Jain, Vikram Sain AU - Jain VS AD - Manav Rachna Dental College, Faridabad, Haryana, India. FAU - Baisoya, Nitik AU - Baisoya N AD - Manav Rachna Dental College, Faridabad, Haryana, India. LA - eng PT - Journal Article DEP - 20251217 PL - India TA - J Pharm Bioallied Sci JT - Journal of pharmacy & bioallied sciences JID - 101537209 PMC - PMC12788475 OTO - NOTNLM OT - Depression OT - internet addiction OT - oral hygiene neglect COIS- There are no conflicts of interest. EDAT- 2026/01/12 06:29 MHDA- 2026/01/12 06:30 PMCR- 2025/12/01 CRDT- 2026/01/12 05:42 PHST- 2025/06/15 00:00 [received] PHST- 2025/06/16 00:00 [revised] PHST- 2025/07/18 00:00 [accepted] PHST- 2026/01/12 06:30 [medline] PHST- 2026/01/12 06:29 [pubmed] PHST- 2026/01/12 05:42 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - JPBS-17-3063 [pii] AID - 10.4103/jpbs.jpbs_1076_25 [doi] PST - ppublish SO - J Pharm Bioallied Sci. 2025 Dec;17(Suppl 4):S3063-S3065. doi: 10.4103/jpbs.jpbs_1076_25. Epub 2025 Dec 17. PMID- 41521841 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260927 IS - 1097-0193 (Electronic) IS - 1065-9471 (Print) IS - 1065-9471 (Linking) VI - 47 IP - 1 DP - 2026 Jan TI - Feasibility and Validity of Ultra-Low-Field MRI for Measurement of Regional Infant Brain Volumes in Structures Associated With Antenatal Maternal Anemia. PG - e70443 LID - 10.1002/hbm.70443 [doi] LID - e70443 AB - The availability of ultra-low-field (ULF) magnetic resonance imaging (MRI) has the potential to improve neuroimaging accessibility in low-resource settings. However, the utility of ULF MRI in detecting child brain changes associated with anemia is unknown. The aim of this study was to assess the comparability of 3T high-field (HF) and 64mT ULF volumes in infants for brain regions associated with antenatal maternal anemia. This neuroimaging substudy is nested within Khula South Africa, a population-based birth cohort. Pregnant women were enrolled antenatally and postnatally, and mother-child dyads (n = 394) were followed prospectively at approximately 3, 6, 12, and 18 months. A subgroup of infants was scanned on 3T and 64mT MRI systems across study visits and images were segmented using MiniMORPH. Correlations and concordance coefficients were used to cross-validate HF and ULF infant brain volumes for the caudate nucleus, putamen, and corpus callosum. Seventy-eight children (53.85% male) had paired HF (mean [SD] age = 9.64 [5.26] months) and ULF (mean [SD] age = 9.47 [5.32] months) datasets. Results indicated strong agreement between systems for intracranial volume (ICV; r = 0.96, rho(ccc) = 0.95) and brain regions of interest in anemia including the caudate nucleus (r = 0.89, rho(ccc) = 0.86), putamen (r = 0.97, rho(ccc) = 0.96) and corpus callosum (r = 0.87, rho(ccc) = 0.79). This cross-validation study demonstrates excellent correspondence between 3T and 64mT volumes for infant brain regions implicated in antenatal maternal anemia. Findings validate the use of ULF MRI for pediatric neuroimaging on anemia in Africa. CI - (c) 2026 The Author(s). Human Brain Mapping published by Wiley Periodicals LLC. FAU - Ringshaw, Jessica E AU - Ringshaw JE AUID- ORCID: 0000-0001-6885-8351 AD - Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa. AD - Neuroscience Institute, University of Cape Town, Cape Town, South Africa. AD - Department of Neuroimaging, Centre for Neuroimaging Sciences, Kings College London, London, England, UK. FAU - Bourke, Niall J AU - Bourke NJ AUID- ORCID: 0000-0001-6478-1430 AD - Department of Neuroimaging, Centre for Neuroimaging Sciences, Kings College London, London, England, UK. FAU - Zieff, Michal R AU - Zieff MR AD - Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa. FAU - Wedderburn, Catherine J AU - Wedderburn CJ AUID- ORCID: 0000-0002-4887-1644 AD - Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa. AD - Neuroscience Institute, University of Cape Town, Cape Town, South Africa. FAU - Casella, Chiara AU - Casella C AUID- ORCID: 0000-0002-0292-3330 AD - Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, England, UK. AD - Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England, UK. FAU - Bradford, Layla E AU - Bradford LE AUID- ORCID: 0000-0002-5195-9081 AD - Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa. AD - Neuroscience Institute, University of Cape Town, Cape Town, South Africa. FAU - Williams, Simone R AU - Williams SR AD - Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa. AD - Neuroscience Institute, University of Cape Town, Cape Town, South Africa. FAU - Herr, Donna AU - Herr D AD - Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa. FAU - Miles, Marlie AU - Miles M AD - Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa. AD - Neuroscience Institute, University of Cape Town, Cape Town, South Africa. FAU - O'Muircheartaigh, Jonathan AU - O'Muircheartaigh J AUID- ORCID: 0000-0002-8033-6959 AD - Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, London, England, UK. AD - Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, England, UK. AD - Medical Research Council (MRC) Centre for Neurodevelopmental Disorders, King's College London, London, England, UK. FAU - Bennallick, Carly AU - Bennallick C AD - Department of Neuroimaging, Centre for Neuroimaging Sciences, Kings College London, London, England, UK. FAU - Deoni, Sean AU - Deoni S AD - Maternal, Newborn, Child Nutrition and Health (MNCH) Discovery and Translational (D&T) Sciences Program, Gates Foundation, Seattle, Washington, USA. FAU - Stein, Dan J AU - Stein DJ AD - Neuroscience Institute, University of Cape Town, Cape Town, South Africa. AD - South African Medical Research Council (SAMRC), Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry, University of Cape Town, Cape Town, South Africa. FAU - Alexander, Daniel C AU - Alexander DC AUID- ORCID: 0000-0003-2439-350X AD - Hawkes Institute and Department of Computer Science, University College London, London, England, UK. FAU - Jones, Derek K AU - Jones DK AUID- ORCID: 0000-0003-4409-8049 AD - Cardiff University Brain Imaging Research Centre (CUBRIC), School of Psychology, Cardiff University, Cardiff, Wales, UK. FAU - Williams, Steven C R AU - Williams SCR AUID- ORCID: 0000-0003-4299-1941 AD - Department of Neuroimaging, Centre for Neuroimaging Sciences, Kings College London, London, England, UK. FAU - Donald, Kirsten A AU - Donald KA AUID- ORCID: 0000-0002-0276-9660 AD - Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, Cape Town, South Africa. AD - Neuroscience Institute, University of Cape Town, Cape Town, South Africa. LA - eng GR - 222076/Z/20/Z/Wellcome Leap/ GR - Science for Africa Foundation with support from Wellcome Trust and the UK Foreign, Commonwealth & Development Office/DELTAS II/ GR - Del-22-002/DELTAS II/ GR - WT_/Wellcome Trust/United Kingdom GR - South African Medical Research Council/ GR - National Institute for Health and Care Research (NIHR) Maudsley Biomedical Research Centre (BRC)/ GR - 224287/Z/21/Z/Wellcome Trust International Training Fellowship/ GR - INV-023509/GATES/Gates Foundation/United States GR - INV-047888/GATES/Gates Foundation/United States PT - Journal Article PL - United States TA - Hum Brain Mapp JT - Human brain mapping JID - 9419065 SB - IM MH - Humans MH - Female MH - *Magnetic Resonance Imaging/methods/standards MH - *Anemia/diagnostic imaging MH - *Brain/diagnostic imaging/pathology/growth & development MH - Infant MH - Pregnancy MH - Male MH - Feasibility Studies MH - Adult MH - Reproducibility of Results MH - Organ Size MH - South Africa PMC - PMC12793889 OTO - NOTNLM OT - antenatal maternal anemia OT - concordance OT - cross-validation OT - high-field MRI OT - infant brain volume OT - low- and middle-income countries OT - ultra-low-field MRI COIS- The authors declare no conflicts of interest. EDAT- 2026/01/12 06:28 MHDA- 2026/01/12 06:29 PMCR- 2026/01/12 CRDT- 2026/01/12 04:14 PHST- 2025/10/27 00:00 [revised] PHST- 2025/06/06 00:00 [received] PHST- 2025/12/13 00:00 [accepted] PHST- 2026/01/12 06:29 [medline] PHST- 2026/01/12 06:28 [pubmed] PHST- 2026/01/12 04:14 [entrez] PHST- 2026/01/12 00:00 [pmc-release] AID - HBM70443 [pii] AID - 10.1002/hbm.70443 [doi] PST - ppublish SO - Hum Brain Mapp. 2026 Jan;47(1):e70443. doi: 10.1002/hbm.70443. PMID- 41520945 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 2154-1671 (Electronic) IS - 2154-1671 (Linking) VI - 16 IP - 2 DP - 2026 Feb 1 TI - Food Insecurity Screening and Interventions: From Hospital to Home. PG - 106-115 LID - 10.1542/hpeds.2025-008559 [doi] AB - BACKGROUND: Household food insecurity (FI) and caregiver inpatient FI (ie, limited or uncertain access to adequate food during hospitalization) negatively affect children. We aimed to describe outcomes of a hospital-based intervention bundle for household/inpatient FI. METHODS: A single-arm prospective clinical trial conducted at a large children's hospital from March 2021 to March 2022 screened English- and Spanish-speaking caregivers. Caregivers with household and/or inpatient FI received the intervention bundle (complimentary hospital meals, active referral to a community-based organization [CBO] for assistance applying for public benefits and accessing food pantries). Two-week postdischarge follow-up calls were completed with caregivers enrolled in the intervention bundle, and the CBO provided 12-month post-referral outcomes. Statistical analysis described the intervention bundle feasibility (% participants who received interventions), acceptability (participant-rated comfort, helpfulness, and satisfaction), and referral outcomes. RESULTS: Of 1000 enrolled caregivers (English-speaking, 75%, Spanish-speaking, 25%), 54% screened positive for household and/or inpatient FI (48% household FI and 46% inpatient FI). 70% of caregivers completed the 2-week follow-up, with median scores of 10/10 comfort with FI screening, 9/10 satisfaction with complimentary trays, and 10/10 satisfaction with CBO. Twelve-month follow-up data demonstrated that the CBO had successfully connected with 62% of referred caregivers. A total of 51% of those who connected applied for Supplemental Nutrition Assistance Program (SNAP), and 86% of those who applied received SNAP benefits within 3 months. CONCLUSIONS: FI was highly prevalent in caregivers of hospitalized children. Hospital-based interventions with a CBO successfully reached caregivers and was rated favorably. This work can inform intervention efforts as hospital FI screening programs grow. CI - Copyright (c) 2026 by the American Academy of Pediatrics. FAU - Lopez, Michelle A AU - Lopez MA AD - Department of Pediatrics, Baylor College of Medicine, Houston, Texas. AD - Center for Child Health Policy and Advocacy, Texas Children's Hospital, Houston, Texas. FAU - Masciale, Marina AU - Masciale M AD - Department of Pediatrics, Baylor College of Medicine, Houston, Texas. FAU - Yu, Xian AU - Yu X AD - Department of Medicine, Baylor College of Medicine, Houston, Texas. FAU - Shaikh, Nusrat AU - Shaikh N AD - Department of Pediatrics, Baylor College of Medicine, Houston, Texas. FAU - Raphael, Jean L AU - Raphael JL AD - Department of Pediatrics, Baylor College of Medicine, Houston, Texas. AD - Center for Child Health Policy and Advocacy, Texas Children's Hospital, Houston, Texas. FAU - Bocchini, Claire E AU - Bocchini CE AD - Department of Pediatrics, Baylor College of Medicine, Houston, Texas. AD - Center for Child Health Policy and Advocacy, Texas Children's Hospital, Houston, Texas. LA - eng PT - Journal Article PL - United States TA - Hosp Pediatr JT - Hospital pediatrics JID - 101585349 SB - IM CIN - Hosp Pediatr. 2026 Feb 1;16(2):e119-e121. doi: 10.1542/hpeds.2025-009026. PMID: 41520937 MH - Humans MH - *Food Insecurity MH - *Caregivers/statistics & numerical data MH - Prospective Studies MH - Female MH - Child, Preschool MH - Male MH - Child MH - *Mass Screening/methods MH - Infant MH - Food Assistance MH - Hospitals, Pediatric MH - Hospitalization EDAT- 2026/01/12 00:37 MHDA- 2026/02/01 00:43 CRDT- 2026/01/11 19:16 PHST- 2025/05/02 00:00 [received] PHST- 2025/10/14 00:00 [accepted] PHST- 2026/02/01 00:43 [medline] PHST- 2026/01/12 00:37 [pubmed] PHST- 2026/01/11 19:16 [entrez] AID - 206078 [pii] AID - 10.1542/hpeds.2025-008559 [doi] PST - ppublish SO - Hosp Pediatr. 2026 Feb 1;16(2):106-115. doi: 10.1542/hpeds.2025-008559. PMID- 41520254 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260703 IS - 0971-5916 (Print) IS - 0971-5916 (Linking) VI - 162 IP - 5 DP - 2025 Nov TI - Setting research priorities for cancer in India: Findings from a CHNRI exercise by ICMR & AIIMS-NCI. PG - 573-580 LID - 10.25259/IJMR_1246_2025 [pii] AB - Background & objectives With limited funding and vast array of research ideas, setting priorities becomes essential to ensure effective and efficient use of resources. This study aims to systematically identify key research questions in cancer through stakeholder engagement using the Child Health and Nutrition Research Initiative method which is a new concept in the Indian context. Methods The Indian Council of Medical Research held a research priority-setting exercise on May 7-8, 2024 at All India Institute of Medical Sciences-National Cancer Institute, Jhajjar, Haryana, engaging 84 participants across India using CHNRI methodology. Experts were divided into four thematic groups. In Step I, each group proposed research questions, which were scored based on five predefined criteria (answerability, efficacy, relevance, deliverability, equity) and arranged in descending order. In Step II, the highest-scoring questions were further validated through full-house voting. Questions receiving a consensus of more than two-third were finalised as priorities. Results In Step I, 99 questions were generated which covered descriptive (n=10), development (n=65), discovery (n=14), and delivery research (n=10). Development group questions were subcategorised as Technologies (diagnostics/devices/digital) (n=17), Therapeutics (n=16), Prevention and screening (n=20), and Palliative care and survivorship (n=12). During validation (Step II), 36 questions across all domains received >66 per cent scores, resulting in research priorities. Interpretation & conclusions The priority setting exercise helped in short listing research questions in area of cancer in India and provided actionable guidance to policymakers and funders enabling appropriate usage of limited funds. FAU - Sharma, Jyoti AU - Sharma J AD - Divisions of Non Communicable Diseases, Indian Council of Medical Research, New Delhi, India. FAU - Thakar, Alok AU - Thakar A AD - Department of Obstetrics & Gynaecology, All India Institute of Medical Sciences, New Delhi, India. AD - Department of Preventive Oncology, National Cancer Institute -All India Institute of Medical Sciences, Bengaluru, Karnataka, India. FAU - Rath, Goura Kishor AU - Rath GK AD - Department of Otolaryngology & Head-Neck Surgery, All India Institute of Medical Sciences, New Delhi, India. AD - Department of Preventive Oncology, National Cancer Institute -All India Institute of Medical Sciences, Bengaluru, Karnataka, India. FAU - Ghosh, Pramit AU - Ghosh P AD - Development Research, Indian Council of Medical Research, New Delhi, India. FAU - Mathur, Prashant AU - Mathur P AD - ICMR-National Centre for Disease Informatics and Research, Bengaluru, Karnataka, India. FAU - Meena, Jitendra Kumar AU - Meena JK AD - Department of Formerly, All India Institute of Medical Sciences, New Delhi, India. FAU - Bharadwaj, Mausumi AU - Bharadwaj M AD - Department of Molecular Genetics & Biochemistry/Molecular Biology, $ICMR- National Institute of Cancer Prevention and Research, Noida, Uttar Pradesh, India. FAU - Shirsat, Neelam AU - Shirsat N AD - Formerly, Advanced Centre for Treatment, Research & Education in Cancer, Mumbai, Maharashtra, India. FAU - Chatterjee, Nabendu Sekhar AU - Chatterjee NS AD - Divisions of Non Communicable Diseases, Indian Council of Medical Research, New Delhi, India. FAU - Chavan, Ajaykiran Shashikiran AU - Chavan AS AD - Divisions of Non Communicable Diseases, Indian Council of Medical Research, New Delhi, India. FAU - Shamsunder, Saritha AU - Shamsunder S AD - Development Research, Indian Council of Medical Research, New Delhi, India. FAU - Singh, Shalini AU - Singh S AD - Department of Molecular Genetics & Biochemistry/Molecular Biology, $ICMR- National Institute of Cancer Prevention and Research, Noida, Uttar Pradesh, India. FAU - Gupta, Sudeep AU - Gupta S AD - Department of Medical Oncology, Tata Memorial Centre, Homi Bhabha National Institute, Mumbai, Maharashtra, India. FAU - Gupta, Taruna Madan AU - Gupta TM AD - Discovery Research, Indian Council of Medical Research, New Delhi, India. FAU - Bhatnagar, Sushma AU - Bhatnagar S AD - Department of Obstetrics & Gynaecology & Gynaecologic Oncology, Vardhaman Mahavir Medical College & Safdarjung Hospital, New Delhi, India. FAU - Bhatla, Neerja AU - Bhatla N AD - Department of Onco-anaesthesia and Palliative Medicine, All India Institute of Medical Sciences, New Delhi, India. FAU - Dhaliwal, Rupinder Singh AU - Dhaliwal RS AD - Divisions of Non Communicable Diseases, Indian Council of Medical Research, New Delhi, India. FAU - Kaur, Tanvir AU - Kaur T AD - Divisions of Non Communicable Diseases, Indian Council of Medical Research, New Delhi, India. CN - ICMR-NCI CHNRI Exercise Group LA - eng PT - Journal Article PL - United States TA - Indian J Med Res JT - The Indian journal of medical research JID - 0374701 SB - IM MH - Humans MH - India/epidemiology MH - *Neoplasms/epidemiology/therapy/diagnosis MH - *Biomedical Research MH - *Research MH - Child MH - *Health Priorities MH - United States PMC - PMC12826369 OTO - NOTNLM OT - CHNRI OT - Cancer OT - ICMR OT - NCI Jhajjar OT - research priority setting COIS- None. FIR - Kannan, Ravi IR - Kannan R IRAD- Cachar Cancer Hospital and Research Centre, Cachar, Assam, India. FIR - Bahl, Amit IR - Bahl A IRAD- Postgraduate Institute of Medical Education and Research, Chandigarh, India. FIR - Singh, Navneet IR - Singh N IRAD- Postgraduate Institute of Medical Education and Research, Chandigarh, India. FIR - Nath, Anita IR - Nath A IRAD- National Centre for Disease Informatics and Research, Bengaluru, Karnataka, India. FIR - S, Gokul IR - S G IRAD- National Centre for Disease Informatics and Research, Bengaluru, Karnataka, India. FIR - Jayasankar IR - Jayasankar IRAD- National Centre for Disease Informatics and Research, Bengaluru, Karnataka, India. FIR - K, Sathish Kumar IR - K SK IRAD- National Centre for Disease Informatics and Research, Bengaluru, Karnataka, India. FIR - Thilagavathi, R IR - Thilagavathi R IRAD- National Centre for Disease Informatics and Research, Bengaluru, Karnataka, India. FIR - Birur, Praveen IR - Birur P IRAD- Karnataka Lingayat Education Society Institute of Dental Science, Karnataka, India. FIR - Salins, Naveen IR - Salins N IRAD- Kasturba Medical College Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, India. FIR - Mm, Sunil Kumar IR - Mm SK IRAD- Pallium India, Trivandrum, Kerala, India. FIR - Narula, Gaurav IR - Narula G IRAD- Tata Memorial Centre, Mumbai, Maharashtra, India. FIR - Prabhash, Kumar IR - Prabhash K IRAD- Tata Memorial Hospital, Mumbai, Maharashtra, India. FIR - Dalal, Sorab IR - Dalal S IRAD- Advanced Centre for Treatment, Research and Education in Cancer, Mumbai, Maharashtra, India. FIR - Hasan, Syed IR - Hasan S IRAD- Advanced Centre for Treatment, Research and Education in Cancer, Mumbai, Maharashtra, India. FIR - Kunwar, Abhishek IR - Kunwar A IRAD- NPC, WHO Country Office for India, New Delhi, India. FIR - Jose, Nisha K IR - Jose NK IRAD- Indian Council of Medical Research Headquarters, New Delhi, India. FIR - Biswas, Ahitagni IR - Biswas A IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Sharma, Aman IR - Sharma A IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Mohan, Anant IR - Mohan A IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Dhar, Anita IR - Dhar A IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Srivastava, Anurag IR - Srivastava A IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Mishra, Ashutosh IR - Mishra A IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Batra, Atul IR - Batra A IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Pushpam, Deepam IR - Pushpam D IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Meena, Jyoti IR - Meena J IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Rangarajan, Krithika IR - Rangarajan K IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Shukla, Pallavi IR - Shukla P IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Malik, Prabhat S IR - Malik PS IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Pramanik, Raja IR - Pramanik R IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Gupta, Ritu IR - Gupta R IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Mishra, Seema IR - Mishra S IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Singhal, Seema IR - Singhal S IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Kumar, Sunil IR - Kumar S IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Mallick, Supriya IR - Mallick S IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Chandrashekhar IR - Chandrashekhar IRAD- All India Institute of Medical Sciences, New Delhi, India. FIR - Kumar, Akash IR - Kumar A IRAD- National Cancer Institute - All India Institute of Medical Sciences, India. FIR - Sharma, Aparna IR - Sharma A IRAD- National Cancer Institute - All India Institute of Medical Sciences, India. FIR - Kataria, Babita IR - Kataria B IRAD- National Cancer Institute - All India Institute of Medical Sciences, India. FIR - Sagiraju, Hari IR - Sagiraju H IRAD- National Cancer Institute - All India Institute of Medical Sciences, India. FIR - Sharma, Jyoti IR - Sharma J IRAD- National Cancer Institute - All India Institute of Medical Sciences, India. FIR - Sirohiya, Prashant IR - Sirohiya P IRAD- National Cancer Institute - All India Institute of Medical Sciences, India. FIR - Panda, Smriti IR - Panda S IRAD- National Cancer Institute - All India Institute of Medical Sciences, India. FIR - Gupta, Anubha IR - Gupta A IRAD- Indraprastha Institute of Information Technology Delhi, India. FIR - Choudhury, Ranjan K IR - Choudhury RK IRAD- Indraprastha Institute of Information Technology Delhi, India. FIR - Sethi, Tavpritesh IR - Sethi T IRAD- Indraprastha Institute of Information Technology Delhi, India. FIR - Gupta, Prakamya IR - Gupta P IRAD- National Health Systems Resource Centre, India. FIR - Bhushan, Himanshu IR - Bhushan H IRAD- National Health Systems Resource Centre, India. FIR - Kankaria, Ankita IR - Kankaria A IRAD- All India Institute of Medical Sciences, Bathinda, Punjab, India. FIR - Gupta, Mayank IR - Gupta M IRAD- All India Institute of Medical Sciences, Bathinda, Punjab, India. FIR - Ganesan, Prasanth IR - Ganesan P IRAD- Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, India. FIR - Selvam, Jerard IR - Selvam J IRAD- National Health Mission, Tamil Nadu, India. FIR - Sundararaj, Jenifer Jeba IR - Sundararaj JJ IRAD- Christian Medical College, Vellore, Tamil Nadu, India. FIR - Swaminathan, R IR - Swaminathan R IRAD- Cancer Institute Adyar (WIA - Women's Indian Association), Chennai, Tamil Nadu, India. FIR - Das, B C IR - Das BC IRAD- Amity University, Noida, Uttar Pradesh, India. FIR - Yadav, C P IR - Yadav CP IRAD- National Institute of Cancer Prevention and Research, Noida, Uttar Pradesh, India. FIR - Gupta, Ekta IR - Gupta E IRAD- National Institute of Cancer Prevention and Research, Noida, Uttar Pradesh, India. FIR - Kumar, Pramod IR - Kumar P IRAD- National Institute of Cancer Prevention and Research, Noida, Uttar Pradesh, India. FIR - Gupta, Ruchika IR - Gupta R IRAD- National Institute of Cancer Prevention and Research, Noida, Uttar Pradesh, India. FIR - Kumar, Sandeep IR - Kumar S IRAD- National Institute of Cancer Prevention and Research, Noida, Uttar Pradesh, India. EDAT- 2026/01/11 17:49 MHDA- 2026/01/11 17:50 PMCR- 2025/11/01 CRDT- 2026/01/11 08:05 PHST- 2025/05/16 00:00 [received] PHST- 2025/09/10 00:00 [accepted] PHST- 2026/01/11 17:50 [medline] PHST- 2026/01/11 17:49 [pubmed] PHST- 2026/01/11 08:05 [entrez] PHST- 2025/11/01 00:00 [pmc-release] AID - 10.25259/IJMR_1246_2025 [pii] AID - 10.25259/IJMR_1246_2025 [doi] PST - ppublish SO - Indian J Med Res. 2025 Nov;162(5):573-580. doi: 10.25259/IJMR_1246_2025. PMID- 41519747 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 1472-6823 (Electronic) IS - 1472-6823 (Linking) VI - 26 IP - 1 DP - 2026 Jan 10 TI - Circulating spexin and adiponectin as early biomarkers of insulin resistance in pediatric obesity. PG - 41 LID - 10.1186/s12902-025-02148-z [doi] LID - 41 AB - BACKGROUND: Insulin resistance (IR) is a central pathological feature of childhood obesity. Spexin (SPX), an emerging endogenous metabolic regulatory peptide, plays a key role in regulating energy metabolism. This study aimed to evaluate the association between IR and serum levels of SPX and adiponectin (ADP) and assess their biomarker potential for predicting IR in children with obesity. METHODS: In total, the study enrolled 104 children (40 normal weight and 64 obese) aged 7-18 years. Further, children with obesity were categorized as having IR (n = 37) or not (n = 27) using a homeostatic model assessment of IR (HOMA-IR) cutoff of >/= 3.0. Anthropometric measurements; biochemical profiles (including glucose, lipid, and liver enzyme levels); and serum concentrations of SPX, Gremlin-1, ADP, leptin (LEP), and tumor necrosis factor-alpha (TNF-alpha) were evaluated. The statistical analyses included correlation tests, multiple linear regression to identify independent determinants of HOMA-IR, and receiver operating characteristic (ROC) curve analysis to assess diagnostic performance. RESULTS: Children with obesity and IR exhibited significantly lower serum SPX levels compared with those without IR, indicating a biphasic pattern characterized by a "compensatory increase" followed by a "decompensated decrease." Multiple linear regressions identified triglycerides (beta = 0.211, p = 0.021), SPX (beta = -0.398, p = 0.049), and ADP (beta = -0.577, p = 0.005) as independent factors associated with HOMA-IR. ROC curve analysis revealed that ADP (area under the curve [AUC] = 0.634) and SPX (AUC = 0.602) had significant, albeit modest, diagnostic value for predicting IR, outperforming Gremlin-1, LEP, and TNF-alpha. CONCLUSIONS: Serum SPX and ADP levels are significantly associated with IR in children with obesity and show potential as complementary early biomarkers. The biphasic change in SPX, characterized by an initial compensatory rise followed by a decompensatory decline, suggests a complex role in metabolic adaptation and failure, underscoring its pathophysiological relevance in the progression from obesity to IR. Thus, a screening approach that combines SPX and ADP may improve early identification of children at risk of obesity. FAU - Lian, Biyao AU - Lian B AD - Department of Pediatrics, The Second Affiliated Hospital of Xi ' an Jiaotong University, Xiwu Road, Xi ' an, Shaanxi, 710000, People's Republic of China. FAU - Ding, Yi AU - Ding Y AD - Department of Pediatrics, The Second Affiliated Hospital of Xi ' an Jiaotong University, Xiwu Road, Xi ' an, Shaanxi, 710000, People's Republic of China. FAU - Zhang, Hongai AU - Zhang H AD - Department of Neonatology, Shanghai General Hospital, Shanghai, China. FAU - Liu, Yuesheng AU - Liu Y AD - Department of Pediatrics, The Second Affiliated Hospital of Xi ' an Jiaotong University, Xiwu Road, Xi ' an, Shaanxi, 710000, People's Republic of China. FAU - Xiao, Yanfeng AU - Xiao Y AD - Department of Pediatrics, The Second Affiliated Hospital of Xi ' an Jiaotong University, Xiwu Road, Xi ' an, Shaanxi, 710000, People's Republic of China. FAU - Yin, Chunyan AU - Yin C AD - Department of Pediatrics, The Second Affiliated Hospital of Xi ' an Jiaotong University, Xiwu Road, Xi ' an, Shaanxi, 710000, People's Republic of China. yinchunyan@xjtu.edu.cn. LA - eng GR - 82373594/the National Natural Science Foundation of China/ GR - T007/IIT Clinical Research Fund of The Second Afliated Hospital of Xi'an Jiaotong University/ PT - Journal Article DEP - 20260110 PL - England TA - BMC Endocr Disord JT - BMC endocrine disorders JID - 101088676 RN - 0 (Adiponectin) RN - 0 (Biomarkers) RN - 0 (Peptide Hormones) RN - 0 (SPX protein, human) RN - 0 (ADIPOQ protein, human) SB - IM MH - Humans MH - *Insulin Resistance MH - Child MH - *Adiponectin/blood MH - *Biomarkers/blood MH - Male MH - *Peptide Hormones/blood MH - Female MH - Adolescent MH - *Pediatric Obesity/blood/diagnosis MH - Prognosis MH - Follow-Up Studies MH - Case-Control Studies PMC - PMC12882346 OTO - NOTNLM OT - Adiponectin OT - Childhood obesity OT - Insulin resistance OT - Spexin COIS- Declarations. Ethics approval and consent to participate: The study protocol was approved by the Ethics Committee of Xi'an Jiaotong University (approval number 2023144/date 2023-03-09). This study was conducted in accordance with the guidelines of the Research Committee of Xi'an Jiaotong University and according to the Declaration of Helsinki. Written informed consent was obtained from all guardians of children participating in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/11 00:34 MHDA- 2026/06/27 06:43 PMCR- 2026/01/10 CRDT- 2026/01/10 23:14 PHST- 2025/09/26 00:00 [received] PHST- 2025/12/22 00:00 [accepted] PHST- 2026/06/27 06:43 [medline] PHST- 2026/01/11 00:34 [pubmed] PHST- 2026/01/10 23:14 [entrez] PHST- 2026/01/10 00:00 [pmc-release] AID - 10.1186/s12902-025-02148-z [pii] AID - 2148 [pii] AID - 10.1186/s12902-025-02148-z [doi] PST - epublish SO - BMC Endocr Disord. 2026 Jan 10;26(1):41. doi: 10.1186/s12902-025-02148-z. PMID- 41519714 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 26 IP - 1 DP - 2026 Jan 10 TI - Prevalence and patterns of sleep disturbances in pediatric psychiatric and non-psychiatric populations: a cross-sectional study in Lebanon. LID - 10.1186/s12888-026-07781-z [doi] LID - 366 AB - BACKGROUND: Sleep is vital to physical, cognitive, and emotional development in children, yet sleep disturbances remain underrecognized, particularly in pediatric psychiatric populations. Prior studies suggest a bidirectional relationship between psychiatric disorders and sleep dysfunction. In Lebanon, the compounded effects of social unrest, economic instability, and widespread psychiatric morbidity have raised concern over pediatric sleep health. This study aims to compare the prevalence and characteristics of sleep disturbances among pediatric patients with and without psychiatric disorders in an outpatient tertiary medical setting, and to identify factors associated with sleep disturbances. METHODS: This cross-sectional study was conducted at the American University of Beirut Medical Center (AUBMC) among children and adolescents presenting to pediatric and pediatric psychiatry outpatient clinics. Sleep disorders were assessed using validated questionnaires. The Adolescent Insomnia Questionnaire (AIQ) for insomnia, the Pediatric Sleep Questionnaire (PSQ) for sleep-disordered breathing, and a single NIH-validated item assessing restless legs syndrome (RLS). Additional sociodemographic, behavioral, and dietary data were collected. Statistical analyses included chi-square testing and multivariate logistic regression to evaluate associations between sleep disturbances and potential predictors. RESULTS: Among 95 participants (mean age 12.4 years; 51.6% male), 48.4% had a psychiatric diagnosis. Sleep disturbances were more prevalent in the psychiatric group (80.4%) versus the non-psychiatric group (61.2%). Insomnia (76.1% vs. 61.2%), RLS (26.1% vs. 18.4%), and sleep-disordered breathing (39.1% vs. 26.5%) were all more common among psychiatric patients. Poor academic performance was significantly associated with sleep disturbances (p < 0.05). In multivariate analysis, a balanced diet was protective (OR = 0.29, p = 0.039), while stress increased the odds of sleep problems (OR = 2.07, p = 0.048). CONCLUSION: Sleep disturbances are highly prevalent among Lebanese children, with modifiable factors such as stress and diet having a greater influence on sleep outcomes than psychiatric status. These findings underscore the need for routine sleep assessment in pediatric clinical care. Addressing sleep hygiene and related behaviors may offer therapeutic benefits and support long-term developmental outcomes. CLINICAL TRIAL NUMBER: Not applicable. FAU - Jaoude, Layane Bou AU - Jaoude LB AD - Psychiatry Department, American University of Beirut, Faculty of Medicine, Beirut, 1107 2020, Lebanon. FAU - Bal, Mark AU - Bal M AD - Psychiatry Department, American University of Beirut, Faculty of Medicine, Beirut, 1107 2020, Lebanon. FAU - Chidiac, Lorenzo AU - Chidiac L AD - Psychiatry Department, American University of Beirut, Faculty of Medicine, Beirut, 1107 2020, Lebanon. FAU - Al-Mir, Mohamad AU - Al-Mir M AD - Psychiatry Department, American University of Beirut, Faculty of Medicine, Beirut, 1107 2020, Lebanon. FAU - Lamah, Elsa AU - Lamah E AD - Psychiatry Department, American University of Beirut, Faculty of Medicine, Beirut, 1107 2020, Lebanon. FAU - Yammine, Jeffrey AU - Yammine J AD - Psychiatry Department, American University of Beirut, Faculty of Medicine, Beirut, 1107 2020, Lebanon. FAU - Wehbe, Mohamad AU - Wehbe M AD - Psychiatry Department, American University of Beirut, Faculty of Medicine, Beirut, 1107 2020, Lebanon. FAU - Antoun, Chadi AU - Antoun C AD - Psychiatry Department, American University of Beirut, Faculty of Medicine, Beirut, 1107 2020, Lebanon. FAU - Sabalbal, Ahmad AU - Sabalbal A AD - Psychiatry Department, American University of Beirut, Faculty of Medicine, Beirut, 1107 2020, Lebanon. FAU - Baroud, Evelyne AU - Baroud E AD - Psychiatry Department, American University of Beirut, Faculty of Medicine, Beirut, 1107 2020, Lebanon. FAU - Talih, Farid AU - Talih F AD - Psychiatry Department, American University of Beirut, Faculty of Medicine, Beirut, 1107 2020, Lebanon. ft10@aub.edu.lb. LA - eng PT - Journal Article DEP - 20260110 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 SB - IM MH - Humans MH - Lebanon/epidemiology MH - Cross-Sectional Studies MH - Female MH - Male MH - Adolescent MH - Child MH - *Mental Disorders/epidemiology/complications MH - Prevalence MH - *Sleep Wake Disorders/epidemiology MH - Surveys and Questionnaires MH - Sleep Initiation and Maintenance Disorders/epidemiology PMC - PMC13141625 OTO - NOTNLM OT - Adolescent sleep OT - Insomnia OT - Lebanon OT - Pediatric psychiatry OT - Restless legs syndrome OT - Sleep disorders OT - Sleep hygiene OT - Sleep-disordered breathing COIS- Declarations. Ethics approval and consent to participate: This study was reviewed and approved by the Institutional Review Board (IRB) of the American University of Beirut Medical Center (AUBMC) under protocol number SBS-2022-0338. All procedures involving human participants were conducted in accordance with the ethical standards of the Institutional Review Board of the AUBMC and with the principles of the Declaration of Helsinki and its later amendments. Written informed consent was obtained from parents or legal guardians, and verbal or written assent was obtained from all participating children prior to inclusion. Participation was entirely voluntary, and confidentiality was maintained throughout the study. Consent for publication: Not applicable. This manuscript does not contain any individual person's data in any form (including individual details, images, or videos). Competing interests: The authors declare no competing interests. EDAT- 2026/01/11 00:34 MHDA- 2026/06/27 04:09 PMCR- 2026/01/10 CRDT- 2026/01/10 23:13 PHST- 2025/10/17 00:00 [received] PHST- 2026/01/02 00:00 [accepted] PHST- 2026/06/27 04:09 [medline] PHST- 2026/01/11 00:34 [pubmed] PHST- 2026/01/10 23:13 [entrez] PHST- 2026/01/10 00:00 [pmc-release] AID - 10.1186/s12888-026-07781-z [pii] AID - 7781 [pii] AID - 10.1186/s12888-026-07781-z [doi] PST - epublish SO - BMC Psychiatry. 2026 Jan 10;26(1):366. doi: 10.1186/s12888-026-07781-z. PMID- 41518793 OWN - NLM STAT- MEDLINE DCOM- 20260220 LR - 20260702 IS - 1873-7358 (Electronic) IS - 1471-0153 (Linking) VI - 60 DP - 2026 Jan TI - Effect of an intuitive eating intervention on disordered eating behaviours and dietary quality in young adult Canadian women: A randomized controlled trial. PG - 102067 LID - S1471-0153(25)00132-1 [pii] LID - 10.1016/j.eatbeh.2025.102067 [doi] AB - BACKGROUND: Disordered eating behaviours (DEBs) are common among young adult women and increase the risk of developing eating disorders. Intuitive eating (IE), a weight-inclusive model emphasizing responsiveness to internal cues (e.g., hunger and satiety signals) and self-compassion, has emerged as a promising approach, but evidence from randomized controlled trials (RCTs) remains limited. Thus, the purpose of the present study was to examine the effect of an IE intervention on intuitive eating, DEBs, and dietary quality in young women. METHODS: In this parallel-group RCT, 106 physically active women (18-35 years) with at least one DEB were randomized to an 8-week group-based IE intervention (N = 53) or wait-list control (N = 53). Weekly sessions were delivered virtually by registered dietitians. Outcomes included IE (IES-2), DEBs (EDE-Q global and Restraint scores, frequency of binge eating, loss-of-control eating, purging, and compensatory exercise), and dietary quality (short Healthy Eating Index). RESULTS: The intervention significantly improved IE global scores. DEBs decreased significantly, with reductions in global EDE-Q and Restraint scores and in the frequency of binge eating, loss-of-control eating, purging, and compensatory exercise. Dietary quality remained unchanged. Retention was high (89 %), and participants reported very high satisfaction towards the intervention and facilitators (mean score 9.6/10). CONCLUSIONS: This study provides evidence that an IE intervention could meaningfully increase IE and reduce DEBs in young adult women across a wide BMI range. Findings support IE's feasibility, acceptability, and potential as a weight-inclusive strategy for prevention and health promotion. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Casgrain, Juliette AU - Casgrain J AD - Department of Psychology, Universite du Quebec a Montreal, 100 Sherbrooke Street, Montreal, Quebec, H2X 3P2, Canada. Electronic address: casgrain.juliette@courrier.uqam.ca. FAU - Njeim, Pressila AU - Njeim P AD - Department of Physical Activity Sciences, Universite du Quebec a Montreal, 141 President-Kennedy Avenue, Montreal, Quebec, H2X 1Y4, Canada. FAU - Hajj-Boutros, Guy AU - Hajj-Boutros G AD - Research Institute of the McGill University Health Center (MUHC), 1001 Decarie Blvd, Montreal, Quebec, H4A 3J1, Canada. FAU - Karelis, Antony D AU - Karelis AD AD - Department of Physical Activity Sciences, Universite du Quebec a Montreal, 141 President-Kennedy Avenue, Montreal, Quebec, H2X 1Y4, Canada. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260107 PL - United States TA - Eat Behav JT - Eating behaviors JID - 101090048 SB - IM MH - Humans MH - Female MH - *Feeding and Eating Disorders/therapy/psychology MH - Young Adult MH - Adult MH - *Feeding Behavior/psychology MH - Adolescent MH - Canada MH - *Intuition MH - *Diet OTO - NOTNLM OT - Diet quality OT - Disordered eating behaviours OT - Eating restraint OT - Internal cues OT - Intuitive eating OT - Weight neutral OT - Young adult women COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/11 00:34 MHDA- 2026/02/21 00:56 CRDT- 2026/01/10 18:03 PHST- 2025/09/25 00:00 [received] PHST- 2025/12/22 00:00 [revised] PHST- 2025/12/29 00:00 [accepted] PHST- 2026/02/21 00:56 [medline] PHST- 2026/01/11 00:34 [pubmed] PHST- 2026/01/10 18:03 [entrez] AID - S1471-0153(25)00132-1 [pii] AID - 10.1016/j.eatbeh.2025.102067 [doi] PST - ppublish SO - Eat Behav. 2026 Jan;60:102067. doi: 10.1016/j.eatbeh.2025.102067. Epub 2026 Jan 7. PMID- 41518792 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 1873-7358 (Electronic) IS - 1471-0153 (Linking) VI - 60 DP - 2026 Jan TI - Body image flexibility and inflexibility predict intuitive eating: A prospective study in adolescents and emerging adults. PG - 102066 LID - S1471-0153(25)00131-X [pii] LID - 10.1016/j.eatbeh.2025.102066 [doi] AB - Young people frequently experience body image threats, and how they cope with these has implications for eating behaviour. Responding flexibly to threats (i.e., openly experiencing negative body-related thoughts and feelings while connecting with a broader sense of self and personal values) may promote adaptive eating behaviours, whereas inflexibility (i.e., resisting uncomfortable experiences and disconnecting from important areas of life) could be detrimental. However, evidence for their roles in predicting intuitive eating is mixed, and research has yet to explore how disordered eating might alter such relationships. To address this gap, this study examined body image flexibility and inflexibility as predictors of intuitive eating components and explored whether eating disorder pathology moderated these relationships. Australian adolescents and emerging adults completed an online survey at two timepoints, Wave 1 (W1; N = 1035) and Wave 2 (W2; N = 351) five months later. Conditional process models indicated that W1 body image flexibility and inflexibility predicted higher and lower W2 reliance on internal eating cues, respectively, with inflexibility also predicting lower levels of W2 eating for physical reasons. Eating disorder pathology did not moderate these effects. Results support the benefits of flexible forms of responding to body image threats, such as by noticing and separating from negative thoughts and engaging in valued activities, instead of trying to avoid or reduce distress, to promote adaptive eating behaviour in young people including those with disordered eating. Future studies should examine the feasibility of integrating these coping strategies within eating disorder prevention and among clinical samples. CI - Copyright (c) 2025. Published by Elsevier Ltd. FAU - Brichacek, Anna L AU - Brichacek AL AD - Discipline of Psychology, Faculty of Health, University of Canberra, Australia. FAU - Neill, James T AU - Neill JT AD - Discipline of Psychology, Faculty of Health, University of Canberra, Australia. Electronic address: James.Neill@canberra.edu.au. FAU - Murray, Kristen AU - Murray K AD - School of Medicine and Psychology, ANU College of Science and Medicine, Australian National University, Australia. FAU - Rieger, Elizabeth AU - Rieger E AD - School of Medicine and Psychology, ANU College of Science and Medicine, Australian National University, Australia. LA - eng PT - Journal Article DEP - 20251222 PL - United States TA - Eat Behav JT - Eating behaviors JID - 101090048 SB - IM MH - Humans MH - Adolescent MH - Female MH - *Body Image/psychology MH - Young Adult MH - Male MH - *Feeding Behavior/psychology MH - *Intuition/physiology MH - *Feeding and Eating Disorders/psychology MH - Prospective Studies MH - Cognitive Flexibility MH - Adult MH - Adaptation, Psychological MH - Australia MH - Self Concept MH - *Eating/psychology OTO - NOTNLM OT - Adolescents OT - Body image flexibility OT - Body image inflexibility OT - Eating disorder pathology OT - Emerging adults OT - Intuitive eating OT - Prospective COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/11 00:34 MHDA- 2026/02/21 00:56 CRDT- 2026/01/10 18:03 PHST- 2025/08/30 00:00 [received] PHST- 2025/12/06 00:00 [revised] PHST- 2025/12/15 00:00 [accepted] PHST- 2026/02/21 00:56 [medline] PHST- 2026/01/11 00:34 [pubmed] PHST- 2026/01/10 18:03 [entrez] AID - S1471-0153(25)00131-X [pii] AID - 10.1016/j.eatbeh.2025.102066 [doi] PST - ppublish SO - Eat Behav. 2026 Jan;60:102066. doi: 10.1016/j.eatbeh.2025.102066. Epub 2025 Dec 22. PMID- 41518737 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260612 IS - 1879-680X (Electronic) IS - 1761-7727 (Linking) VI - 24 IP - 2S DP - 2026 Jun TI - Assessment of pre-treatment diagnostic characteristics in patients with borderline bimaxillary protrusion: A pilot comparison of bi-jaw distalization versus premolar extraction. PG - 101134 LID - S1761-7227(25)00169-X [pii] LID - 10.1016/j.ortho.2025.101134 [doi] AB - BACKGROUND: Patients with bimaxillary protrusion often seek orthodontic treatment to improve facial aesthetics. Treatment planning is complex and may involve premolar extractions or bi-jaw distalization using temporary anchorage devices (TADs) and third molar extractions. Choice of modality is partly subjective, particularly in borderline cases. OBJECTIVE: To assess pre-treatment arch forms, dentoskeletal, and soft-tissue characteristics for guiding treatment selection between bi-jaw distalization and premolar extraction in borderline bimaxillary protrusion. The secondary objective was to compare these characteristics between the two treatment groups. METHODOLOGY: This retrospective pilot study included all patient records meeting inclusion criteria from January 2022 to December 2024. A total of 26 patients with borderline bimaxillary protrusion were analysed and categorized into two groups: bimaxillary distalization (n=13) and premolar extraction (n=13). Pre-treatment CBCT-derived digital models were used for 3D polynomial arch-form analysis, alongside cephalometric assessment. Groups were compared using chi-square tests for categorical data and Student's t-tests for continuous variables. RESULTS: Among 26 patients (9 males, 17 females; mean age 20.81+/-3.72years), square arch forms were more frequent in the bi-jaw distalization group (61.5%; 95% CI: 35.5-82.3). Cephalometric parameters did not differ significantly between groups (P>0.05). Measurement reliability was high (ICC: 0.76-0.81). CONCLUSION: Within this pilot retrospective study, arch form morphology was associated with treatment choice. Evaluating arch form alongside dento-skeletal and soft-tissue features may aid personalized planning for borderline bimaxillary protrusion. These observations are descriptive and non-causal; larger prospective studies are needed to validate pre-treatment arch forms. CI - Copyright (c) 2025 CEO. Published by Elsevier Masson SAS. All rights reserved. FAU - Gautam, Rajaganesh AU - Gautam R AD - Department of Orthodontics and Dentofacial Orthopedics, Dr. D. Y. Patil Dental College and Hospital, Dr. D. Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Maharashtra, Pimpri, Pune, India. FAU - Ahuja, Dhruv AU - Ahuja D AD - Department of Orthodontics and Dentofacial Orthopedics, Manav Rachna Dental College, Faridabad, Manav Rachna International Institute of Research and Studies (MRIIRS), Haryana, India. Electronic address: dhruvahuja96@gmail.com. FAU - Shetty, Siddarth AU - Shetty S AD - Department of Orthodontics and Dentofacial Orthopedics, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education Manipal, Karnataka, India. FAU - Ashith, M Varadraj AU - Ashith MV AD - Department of Orthodontics and Dentofacial Orthopedics, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education Manipal, Karnataka, India. FAU - Batra, Puneet AU - Batra P AD - Department of Orthodontics and Dentofacial Orthopedics, Manav Rachna Dental College, Faridabad, Manav Rachna International Institute of Research and Studies (MRIIRS), Haryana, India. FAU - Chandhini, G AU - Chandhini G AD - Department of Mathematical and Computational Sciences, National Institute of Technology Karnataka, Surathkal, PO Srinivasanagar, 575025 Karnataka, India. FAU - Khera, Anshu AU - Khera A AD - Franklin High School, Franklin Board of Education, Somerset, NJ, United States. FAU - Mithra, Prasanna AU - Mithra P AD - Department of Community Medicine, Kasturba Medical College, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India. FAU - Shenoy, Nandita AU - Shenoy N AD - Department of Oral Medicine and Radiology, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, Manipal, Karnataka, India. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260109 PL - France TA - Int Orthod JT - International orthodontics JID - 101184882 SB - IM MH - Humans MH - Female MH - Pilot Projects MH - Retrospective Studies MH - *Bicuspid/surgery MH - *Tooth Extraction/methods MH - Cephalometry MH - *Tooth Movement Techniques/methods MH - Male MH - Adolescent MH - Cone-Beam Computed Tomography MH - Orthodontic Anchorage Procedures MH - *Malocclusion/therapy OTO - NOTNLM OT - Bijaw distalization OT - Bimaxillary protrusion OT - Dentoskeletal features OT - Premolar extractions COIS- Disclosure of interest The authors declare that they have no competing interest. EDAT- 2026/01/11 00:34 MHDA- 2026/06/13 00:39 CRDT- 2026/01/10 18:02 PHST- 2025/11/08 00:00 [received] PHST- 2025/12/08 00:00 [revised] PHST- 2025/12/10 00:00 [accepted] PHST- 2026/06/13 00:39 [medline] PHST- 2026/01/11 00:34 [pubmed] PHST- 2026/01/10 18:02 [entrez] AID - S1761-7227(25)00169-X [pii] AID - 10.1016/j.ortho.2025.101134 [doi] PST - ppublish SO - Int Orthod. 2026 Jun;24(2S):101134. doi: 10.1016/j.ortho.2025.101134. Epub 2026 Jan 9. PMID- 41517747 OWN - NLM STAT- MEDLINE DCOM- 20260110 LR - 20260520 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 105 IP - 2 DP - 2026 Jan 9 TI - The juji-gatame technique can be used in the special judo fitness test to evaluate fitness condition in grappling fighters: A crossover trial. PG - e44255 LID - 10.1097/MD.0000000000044255 [doi] LID - e44255 AB - BACKGROUND: The special judo fitness test (SJFT) is a widely used tool for assessing physical fitness in grappling athletes. However, its conventional format, centered on the ippon-seoi-nage throwing technique, may not adequately evaluate athletes specializing in ground-fighting techniques. Incorporating a ground-based technique, such as juji-gatame (JG), could enhance the test's applicability for diverse grappling disciplines. To evaluate the feasibility and reliability of using the JG instead of the ippon-seoi-nage in the SJFT to assess physical fitness in grappling athletes. METHODS: A randomized crossover trial was conducted with 150 male grappling athletes, including 94 juniors (13.4 +/- 2.3 years; categorized by Tanner stages: 17 prepubertal, 48 pubertal, and 28 postpubertal) and 56 adults (30.3 +/- 9.7 years). Participants performed both the conventional SJFT (using ippon-seoi-nage) and the adapted SJFT-JG (using juji-gatame) in a randomized order, with a 24-hour washout period between tests. Performance was assessed using the SJFT index and reliability metrics. Seven days later, a retest was conducted for both versions of the SJFT, again with a 24-hour interval between tests. It is important to note that the adapted version of the SJFT was performed using a training dummy. RESULTS: The SJFT-JG demonstrated strong absolute (ICC = 0.99, LoA = -8.7; 7.8) and relative reliability (ICC = 0.98, LoA = -0.18; 0.16). No significant differences were observed in SJFT index scores between the 2 versions (P >.05), indicating physiological equivalence. CONCLUSION: JG can be reliably integrated into the SJFT as an alternative to ippon-seoi-nage, broadening the test's applicability for grappling athletes, particularly those emphasizing ground techniques. This adaptation provides a practical and valid method for evaluating physical fitness across diverse grappling styles. CI - Copyright (c) 2026 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - de Almeida-Neto, Paulo Francisco AU - de Almeida-Neto PF AD - Health Sciences Center, Federal University of Rio Grande do Norte, CCS-UFRN, Natal, Brazil. AD - Department of Physical Education, Federal University of Rio Grande do Norte, DEF-UFRN, Natal, Brazil. FAU - Bulhoes-Correia, Alexandre AU - Bulhoes-Correia A AD - Department of Physical Education, Federal University of Rio Grande do Norte, DEF-UFRN, Natal, Brazil. FAU - de Assis, Gilmara Gomes AU - de Assis GG AD - Escola Superior Desporto e Lazer, Instituto Politecnico de Viana do Castelo, Rua Escola Industrial e Comercial de Nun'Alvares, Viana do Castelo, Portugal. AD - Sport Physical Activity and Health Research and Innovation Center, Viana do Castelo, Portugal. FAU - Ceylan, Halil Ibrahim AU - Ceylan HI AD - Physical Education and Sports Teaching Department, Kazim Karabekir Faculty of Education, Ataturk University, Erzurum, Turkey. FAU - Rocha, Roberto Felipe Camara AU - Rocha RFC AD - Department of Physical Education, Federal University of Rio Grande do Norte, DEF-UFRN, Natal, Brazil. FAU - Medeiros da Silva, Iago AU - Medeiros da Silva I AD - Department of Physical Education, Federal University of Rio Grande do Norte, DEF-UFRN, Natal, Brazil. FAU - Gomes da Silva, Jose Carlos AU - Gomes da Silva JC AD - Department of Physical Education, Federal University of Rio Grande do Norte, DEF-UFRN, Natal, Brazil. FAU - Silva Dantas, Paulo Moreira AU - Silva Dantas PM AD - Health Sciences Center, Federal University of Rio Grande do Norte, CCS-UFRN, Natal, Brazil. AD - Department of Physical Education, Federal University of Rio Grande do Norte, DEF-UFRN, Natal, Brazil. FAU - Stefanica, Valentina AU - Stefanica V AUID- ORCID: 0000-0003-4031-1412 AD - Department of Physical Education and Sport, Faculty of Sciences, Physical Education and Informatics, National University of Science and Technology Politehnica Bucharest, Pitesti University Center, Pitesti, Romania. FAU - Cabral, Breno Guilherme de Araujo Tinoco AU - Cabral BGAT AD - Health Sciences Center, Federal University of Rio Grande do Norte, CCS-UFRN, Natal, Brazil. AD - Department of Physical Education, Federal University of Rio Grande do Norte, DEF-UFRN, Natal, Brazil. LA - eng GR - Process: #157144/2021-6/Doctoral scholarship from the National Council for Scientific Development (CNPQ)/ PT - Journal Article PT - Randomized Controlled Trial PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - Male MH - Cross-Over Studies MH - *Physical Fitness/physiology MH - Adult MH - *Martial Arts/physiology MH - *Exercise Test/methods MH - Adolescent MH - Reproducibility of Results MH - Young Adult MH - Athletes MH - Child MH - Athletic Performance/physiology MH - Feasibility Studies PMC - PMC12794994 OTO - NOTNLM OT - anaerobic capacity OT - combat sports OT - jiu-jitsu OT - sport OT - wrestling COIS- The authors have no conflicts of interest to disclose. EDAT- 2026/01/10 06:32 MHDA- 2026/01/10 06:33 PMCR- 2026/01/09 CRDT- 2026/01/10 01:18 PHST- 2025/03/25 00:00 [received] PHST- 2025/08/13 00:00 [accepted] PHST- 2026/01/10 06:33 [medline] PHST- 2026/01/10 06:32 [pubmed] PHST- 2026/01/10 01:18 [entrez] PHST- 2026/01/09 00:00 [pmc-release] AID - 00005792-202601090-00094 [pii] AID - MD-D-25-03237 [pii] AID - 10.1097/MD.0000000000044255 [doi] PST - ppublish SO - Medicine (Baltimore). 2026 Jan 9;105(2):e44255. doi: 10.1097/MD.0000000000044255. PMID- 41517396 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260110 LR - 20260113 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 1 DP - 2025 Dec 24 TI - Development of Novel Predictive Scores for Obstetrical Risk Stratification in Adolescent Pregnancies: A Retrospective Study. LID - 10.3390/jcm15010139 [doi] LID - 139 AB - Background: Adolescent pregnancies represent a significant global health challenge, with increased risks of maternal and neonatal complications. Traditional obstetrical risk assessment tools have limited applicability in this population due to unique physiological and anatomical characteristics. This study aimed to develop and validate novel predictive scores specifically designed for obstetrical risk stratification in adolescent pregnancies. Methods: A retrospective study was conducted over seven years (2018-2024) in Brasov County, Romania, including 1322 adolescent pregnancies (ages 12-16 years). Two novel predictive scores were developed: the Cervical Ripening Ultrasound Index (CRUI) for predicting successful vaginal delivery and labor induction, and the ADOLESRISK score for comprehensive obstetrical risk stratification. Statistical analysis included logistic regression, ROC curve analysis, and validation testing using SPSS 26.0 and R Studio version 4.3.2. Results: The CRUI score demonstrated superior predictive performance (AUC = 0.87, 95% CI: 0.84-0.90) compared to traditional Bishop score (AUC = 0.62, 95% CI: 0.58-0.66) for successful labor induction in adolescents. The ADOLESRISK score achieved 84% sensitivity and 76% specificity for predicting major obstetrical complications, significantly outperforming conventional risk assessment tools. Key risk factors incorporated included maternal age, educational level, nutritional status, and specific ultrasound parameters. Internal validation using train-test split methodology (70-30%) confirmed robust performance in the independent validation cohort (n = 397), with maintained discriminative ability (CRUI: AUC = 0.85, 95% CI: 0.80-0.90; ADOLESRISK: AUC = 0.82, 95% CI: 0.77-0.87) across different demographic subgroups. Conclusions: The CRUI and ADOLESRISK scores represent significant advances in adolescent obstetrical care, providing clinicians with tools for personalized risk assessment and management. Implementation of these scores could potentially reduce maternal complications by 25-30% and improve neonatal outcomes by 20-25%, representing a major contribution to adolescent reproductive health globally. FAU - Khudor, Abdul Jabar AU - Khudor AJ AD - Medicine PhD School, Transilvania University of Brasov, 500036 Brasov, Romania. FAU - Moga, Marius Alexandru AU - Moga MA AUID- ORCID: 0000-0002-2442-6917 AD - Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania. FAU - Dimienescu, Oana Gabriela AU - Dimienescu OG AUID- ORCID: 0000-0001-9407-389X AD - Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania. FAU - Nicolau, Andrada Camelia AU - Nicolau AC AD - Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania. FAU - Arvatescu, Cristian Andrei AU - Arvatescu CA AD - Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania. FAU - Hogea, Mircea Daniel AU - Hogea MD AUID- ORCID: 0000-0001-7586-7205 AD - Faculty of Medicine, Transilvania University of Brasov, 500036 Brasov, Romania. LA - eng PT - Journal Article DEP - 20251224 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC12786813 OTO - NOTNLM OT - ADOLESRISK OT - CRUI OT - adolescent pregnancy OT - cervical ripening OT - obstetrical risk OT - predictive scores OT - pregnancy complications OT - risk stratification COIS- The authors declare no conflicts of interest. EDAT- 2026/01/10 06:31 MHDA- 2026/01/10 06:32 PMCR- 2025/12/24 CRDT- 2026/01/10 01:15 PHST- 2025/11/17 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2025/12/19 00:00 [accepted] PHST- 2026/01/10 06:32 [medline] PHST- 2026/01/10 06:31 [pubmed] PHST- 2026/01/10 01:15 [entrez] PHST- 2025/12/24 00:00 [pmc-release] AID - jcm15010139 [pii] AID - jcm-15-00139 [pii] AID - 10.3390/jcm15010139 [doi] PST - epublish SO - J Clin Med. 2025 Dec 24;15(1):139. doi: 10.3390/jcm15010139. PMID- 41517385 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260110 LR - 20260113 IS - 2077-0383 (Print) IS - 2077-0383 (Electronic) IS - 2077-0383 (Linking) VI - 15 IP - 1 DP - 2025 Dec 24 TI - Pediatric MASLD in Severe Obesity: Current Clinical Perspectives on Diagnosis and Treatment. LID - 10.3390/jcm15010137 [doi] LID - 137 AB - Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is now one of the most common chronic liver diseases in children and closely parallels the rising prevalence of severe pediatric obesity. Methods: This review synthesizes current evidence (2019-2025) and landmark studies on the diagnosis and management of pediatric MASLD, integrating contemporary guidelines and future directions. Results: Based on current data, we propose practical algorithms for screening and management of pediatric MASLD. Screening with alanine aminotransferase (ALT) as the initial test should be initiated in all children aged 9-11 years with obesity, in those who are overweight with additional risk factors, and in children with severe obesity or a family history of MASLD. Non-invasive imaging techniques show important limitations in children with increased amount of subcutaneous tissue requiring cautious interpretation. Lifestyle modification remains the cornerstone of therapy, while pharmacological treatments are investigational. In adolescents with severe obesity and significant comorbidities, bariatric surgery represents an effective therapeutic option with durable metabolic effects. Conclusions: Early identification of high-risk children, especially those with severe obesity, and implementation of multidisciplinary management are essential to prevent MASLD progression. Refinement of screening strategies and development of validated non-invasive biomarkers remain key priorities for future pediatric care. FAU - Kostrzeba, Ewa AU - Kostrzeba E AUID- ORCID: 0000-0001-6468-1819 AD - Department of Pediatrics, Endocrinology and Diabetology of the Development Age, Pomeranian Medical University in Szczecin, 71-252 Szczecin, Poland. FAU - Bik-Multanowski, Miroslaw AU - Bik-Multanowski M AUID- ORCID: 0000-0003-1542-7050 AD - Department of Medical Genetics, Jagiellonian University Medical College, 31-008 Cracow, Poland. AD - University Hospital, Institute of Human Genetics, LMU, 80336 Munchen, Germany. FAU - Brandt-Heunemann, Stephanie AU - Brandt-Heunemann S AUID- ORCID: 0000-0002-8693-2647 AD - Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent, Medicine, University Medical Center Ulm, 89075 Ulm, Germany. AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Ulm, 89075 Ulm, Germany. FAU - Malecka-Tendera, Ewa AU - Malecka-Tendera E AUID- ORCID: 0000-0002-2693-7622 AD - Department of Pediatrics and Pediatric Endocrinology, Medical University of Silesia, 40-752 Katowice, Poland. FAU - Mazur, Artur AU - Mazur A AUID- ORCID: 0000-0001-5393-3515 AD - Department of Pediatrics, Pediatric Endocrinology and Diabetes, Institute of Medical Sciences, Medical College of Rzeszow University, 35-301 Rzeszow, Poland. FAU - Ranke, Michael B AU - Ranke MB AUID- ORCID: 0000-0002-3855-6157 AD - Children's Hospital in Tubingen, University of Tubingen, 72076 Tubingen, Germany. FAU - Wabitsch, Martin AU - Wabitsch M AUID- ORCID: 0000-0001-6795-8430 AD - Division of Pediatric Endocrinology and Diabetes, Department of Pediatrics and Adolescent, Medicine, University Medical Center Ulm, 89075 Ulm, Germany. AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Ulm, 89075 Ulm, Germany. FAU - Wojcik, Malgorzata AU - Wojcik M AUID- ORCID: 0000-0003-3889-1913 AD - Department of Pediatric and Adolescent Endocrinology, Pediatric Institute, Jagiellonian University Medical College, 31-008 Cracow, Poland. FAU - Zachurzok, Agnieszka AU - Zachurzok A AUID- ORCID: 0000-0002-7330-7607 AD - Department of Pediatrics, Faculty of Medical Sciences, Medical University of Silesia in Zabrze, 41-800 Zabrze, Poland. FAU - Petriczko, Elzbieta AU - Petriczko E AUID- ORCID: 0000-0002-1251-6798 AD - Department of Pediatrics, Endocrinology and Diabetology of the Development Age, Pomeranian Medical University in Szczecin, 71-252 Szczecin, Poland. LA - eng GR - (2021/41/B/NZ5/01676)./National Science Center, Poland/ PT - Journal Article PT - Review DEP - 20251224 PL - Switzerland TA - J Clin Med JT - Journal of clinical medicine JID - 101606588 PMC - PMC12787233 OTO - NOTNLM OT - MASLD OT - childhood obesity OT - severe obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/01/10 06:31 MHDA- 2026/01/10 06:32 PMCR- 2025/12/24 CRDT- 2026/01/10 01:15 PHST- 2025/11/28 00:00 [received] PHST- 2025/12/22 00:00 [revised] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/01/10 06:32 [medline] PHST- 2026/01/10 06:31 [pubmed] PHST- 2026/01/10 01:15 [entrez] PHST- 2025/12/24 00:00 [pmc-release] AID - jcm15010137 [pii] AID - jcm-15-00137 [pii] AID - 10.3390/jcm15010137 [doi] PST - epublish SO - J Clin Med. 2025 Dec 24;15(1):137. doi: 10.3390/jcm15010137. PMID- 41517013 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260110 LR - 20260926 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 1 DP - 2025 Dec 30 TI - Adapted Judo as a Multidimensional Intervention: Effects on Physical Fitness and Psychosocial Well-Being in Adolescents with Down Syndrome. LID - 10.3390/healthcare14010081 [doi] LID - 81 AB - Background/Objectives: Adolescents with Down syndrome often present limitations in physical fitness and psychosocial well-being, which can affect their health and social inclusion. Adapted physical activity programs, such as martial arts, may offer multidimensional benefits. This study aimed to analyze the effects of an adapted judo intervention on physical fitness and psychosocial outcomes in adolescents with Down syndrome. Methods: A quasi-experimental design was applied with 43 adolescents diagnosed with Down syndrome, allocated to a control group (n = 19) and an intervention group (n = 24). Participants in the intervention group completed a 24-week adapted judo program. Physical fitness was assessed through standardized tests for strength, balance, and flexibility, while psychosocial well-being was evaluated using validated questionnaires on self-esteem and social interaction. Pre- and post-intervention comparisons were conducted using appropriate statistical analyses. Results: Participants showed significant improvements in physical fitness components, particularly in muscular strength and balance (p < 0.05). Flexibility also increased, although to a lesser extent. Psychosocial measures revealed enhanced self-esteem and greater perceived social interaction, indicating positive effects beyond physical health. Conclusions: Adapted judo appears to be an effective multidimensional intervention for adolescents with Down syndrome, promoting both physical and psychosocial benefits. These findings support the inclusion of adapted martial arts in physical education and therapeutic programs aimed at fostering health and social participation in this population. FAU - Suarez-Villadat, Borja AU - Suarez-Villadat B AUID- ORCID: 0000-0003-1574-868X AD - Department of Physical Therapy, Occupational Therapy, Rehabilitation and Physical Medicine, Health Sciences Faculty, Universidad Rey Juan Carlos, 28922 Madrid, Spain. FAU - Montero, Mario AU - Montero M AD - Faculty of Sport Science, Pablo Olavide University, 41013 Sevilla, Spain. AD - Faculty of Biomedical and Health Sciences, Alfonso X el Sabio University, 28691 Madrid, Spain. FAU - Montero, Sonia AU - Montero S AD - Faculty of Sport Science, Pablo Olavide University, 41013 Sevilla, Spain. AD - Faculty of Biomedical and Health Sciences, Alfonso X el Sabio University, 28691 Madrid, Spain. FAU - Lopez-Garcia, Adrian AU - Lopez-Garcia A AUID- ORCID: 0009-0004-2686-3944 AD - Sport Sciences Research Centre, Universidad Rey Juan Carlos, 28942 Madrid, Spain. FAU - Villagra, Ariel AU - Villagra A AUID- ORCID: 0000-0003-3666-5453 AD - Department of Physical Education, Sport and Human Movement, Autonomous University of Madrid, 28049 Madrid, Spain. LA - eng PT - Journal Article DEP - 20251230 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12785297 OTO - NOTNLM OT - Down syndrome OT - adapted judo OT - inclusive physical activity OT - physical fitness OT - psychosocial well-being COIS- The authors declare no conflicts of interest. EDAT- 2026/01/10 06:31 MHDA- 2026/01/10 06:32 PMCR- 2025/12/30 CRDT- 2026/01/10 01:13 PHST- 2025/11/18 00:00 [received] PHST- 2025/12/07 00:00 [revised] PHST- 2025/12/26 00:00 [accepted] PHST- 2026/01/10 06:32 [medline] PHST- 2026/01/10 06:31 [pubmed] PHST- 2026/01/10 01:13 [entrez] PHST- 2025/12/30 00:00 [pmc-release] AID - healthcare14010081 [pii] AID - healthcare-14-00081 [pii] AID - 10.3390/healthcare14010081 [doi] PST - epublish SO - Healthcare (Basel). 2025 Dec 30;14(1):81. doi: 10.3390/healthcare14010081. PMID- 41517007 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260110 LR - 20260113 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 14 IP - 1 DP - 2025 Dec 27 TI - Evaluation of DAid((R)) Smart Socks for Foot Plantar Center of Pressure Measurements in Football-Specific Tasks: A Preliminary Validation Study. LID - 10.3390/healthcare14010076 [doi] LID - 76 AB - Background/Objectives: Accurate plantar pressure assessment is essential for injury prevention and rehabilitation monitoring in sports. Wearable sensor technologies, such as DAid((R)) Smart Socks, offer portable, real-time biomechanical feedback and enable data collection in field conditions. However, there is limited evidence on their level of agreement with a gold standard in measuring the foot plantar center of pressure (CoP) in football-specific tasks. This study aimed to determine the preliminary validity of DAid((R)) Smart Socks compared with a gold-standard force platform in measuring plantar center of pressure (CoP) during functional football FIFA 11+ Part 2 exercises. Methods: Ten male volunteer youth football players (mean age 12.2 +/- 0.42 years; height 158.7 +/- 7.72 cm; weight 46.46 +/- 8.78 kg; shoe size EU 39.8 +/- 2.68) from the Latvian Football Federation Youth League participated. Eight players had right-leg dominance, two had left-leg dominance; three reported past lower-limb injuries. Plantar pressure was measured simultaneously using DAid((R)) Smart Socks and a 1.5 m entry-level force platform with a calibration factor of 3.2. Center of pressure (CoP) data from the force platform were recorded using Footscan software version 9.10.4. Participants performed two selected FIFA 11+ Part 2 exercises-a single-leg squat (unilateral) and a squat with heel raise, performed bilaterally-under standardized conditions. Each exercise was performed twice, with sock removal and reapplication between trials. Agreement between the DAid((R)) Smart Socks and the force platform was examined using waveform synchronization, root mean square error (RMSE), Bland-Altman analysis, and Lin's Concordance Correlation Coefficient (CCC) to quantify both relative waveform correspondence and absolute CoP measurement accuracy. Results: Across 160 paired recordings, the DAid((R)) Smart Socks showed moderate-to-high correlation with the force platform for relative CoP dynamics, with 79% of waveforms demonstrating CCC >/= 0.60. Absolute agreement was limited, with only 16% of recordings reaching CCC >/= 0.90, and RMSE values ranging from 2.1 to 18.9 mm (X) and 4.3-34.2 mm (Y). Conclusions: DAid((R)) Smart Socks showed moderate-to-high correspondence with the force platform in capturing the directional and temporal characteristics of plantar CoP during functional football tasks, with agreement varying across individuals. FAU - Davidovica, Anna AU - Davidovica A AUID- ORCID: 0000-0002-3141-7998 AD - Department of Rehabilitation, Riga Stradins University, 16 Dzirciema Street, LV-1007 Riga, Latvia. FAU - Semjonova, Guna AU - Semjonova G AUID- ORCID: 0000-0002-6554-0716 AD - Department of Rehabilitation, Riga Stradins University, 16 Dzirciema Street, LV-1007 Riga, Latvia. FAU - Katasevs, Aleksejs AU - Katasevs A AUID- ORCID: 0000-0001-8894-3748 AD - Institute of Mechanical and Biomedical Engineering, Riga Technical University, LV-1048 Riga, Latvia. FAU - Okss, Aleksandrs AU - Okss A AUID- ORCID: 0000-0001-6925-1842 AD - Institute of Architecture and Design, Riga Technical University, LV-1048 Riga, Latvia. FAU - Nesterovica, Darja AU - Nesterovica D AUID- ORCID: 0000-0003-1344-0067 AD - Institute of Public Health, Riga Stradins University, Kronvalda bulvaris 9, LV-1010, Riga, Latvia. FAU - Tomsone, Signe AU - Tomsone S AUID- ORCID: 0000-0002-7836-2672 AD - Department of Rehabilitation, Riga Stradins University, 16 Dzirciema Street, LV-1007 Riga, Latvia. LA - eng GR - lzp-2023/1-0027/Latvian Council of Science/ PT - Journal Article DEP - 20251227 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12785565 OTO - NOTNLM OT - FIFA 11+ exercises OT - football OT - plantar pressure OT - preliminary validity OT - wearable sensors COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/01/10 06:32 MHDA- 2026/01/10 06:33 PMCR- 2025/12/27 CRDT- 2026/01/10 01:13 PHST- 2025/10/30 00:00 [received] PHST- 2025/12/18 00:00 [revised] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/01/10 06:33 [medline] PHST- 2026/01/10 06:32 [pubmed] PHST- 2026/01/10 01:13 [entrez] PHST- 2025/12/27 00:00 [pmc-release] AID - healthcare14010076 [pii] AID - healthcare-14-00076 [pii] AID - 10.3390/healthcare14010076 [doi] PST - epublish SO - Healthcare (Basel). 2025 Dec 27;14(1):76. doi: 10.3390/healthcare14010076. PMID- 41516406 OWN - NLM STAT- MEDLINE DCOM- 20260110 LR - 20260115 IS - 1422-0067 (Electronic) IS - 1422-0067 (Linking) VI - 27 IP - 1 DP - 2026 Jan 5 TI - Novel SIM1 Variants Expanding the Spectrum of SIM1-Related Obesity. LID - 10.3390/ijms27010533 [doi] LID - 533 AB - Monogenic forms of severe early-onset obesity often involve genetic disruptions in the hypothalamic leptin-melanocortin pathway. Pathogenic variants in the SIM1 gene, a key transcription factor required for the development of the paraventricular nucleus, are a known cause of Prader-Willi-like syndrome, characterized by hyperphagia, severe obesity, and developmental delay. We performed targeted next-generation sequencing of 52 obesity-associated genes on a cohort of pediatric patients with severe early-onset obesity. Identified variants were analyzed for population frequency and predicted pathogenicity using in silico tools. The structural impact of the novel missense variants was assessed using protein domain modeling with AlphaFold3. We identified five rare SIM1 variants in eleven patients. Four were heterozygous nonsynonymous variants: one frameshift in the bHLH domain (p.Ser18Ter), one frameshift in the Per-ARNT-Sim domain (p.His143Ter), and two missense variants, p.Pro30Ala and p.Ser663Leu. Structural modeling suggested that the missense variants are likely to disrupt critical protein-protein interactions. The fifth variant was a synonymous change, c.1173G>A, p.(Ser391Ser), which was detected in five unrelated patients. Bioinformatic analysis predicted that this variant could alter splicing. Structural modeling suggested that the missense variants interfere with SIM1 function. This study expands the mutational spectrum of SIM1-linked monogenic obesity, reporting novel likely pathogenic frameshift variants, a missense variant, and a recurrent synonymous variant with a potential splice-site effect. The majority of the variants are predicted to affect the SIM1 protein. Our findings strengthen the critical role of the SIM1 gene in hypothalamic development and energy homeostasis. The results underscore the importance of including the SIM1 gene in genetic testing panels for children with severe obesity and hyperphagia, enabling precise diagnosis and potential future personalized management. Functional in vitro or in vivo validation of these variants is required to confirm their pathogenicity. FAU - Mohammed, Idris AU - Mohammed I AUID- ORCID: 0000-0002-8983-0929 AD - College of Health & Life Sciences, Hamad Bin Khalifa University, Doha P.O. Box 34110, Qatar. AD - Division of Endocrinology, Department of Pediatric Medicine, Sidra Medicine, Doha P.O. Box 26999, Qatar. FAU - Ahmed, Wesam S AU - Ahmed WS AUID- ORCID: 0000-0002-3441-2631 AD - College of Health & Life Sciences, Hamad Bin Khalifa University, Doha P.O. Box 34110, Qatar. FAU - Al-Barazenji, Tara AU - Al-Barazenji T AD - Division of Endocrinology, Department of Pediatric Medicine, Sidra Medicine, Doha P.O. Box 26999, Qatar. FAU - Dauleh, Hajar AU - Dauleh H AD - Division of Endocrinology, Department of Pediatric Medicine, Sidra Medicine, Doha P.O. Box 26999, Qatar. FAU - Love, Donald R AU - Love DR AUID- ORCID: 0000-0003-4669-8769 AD - Division of Genetic Pathology, Department of Pathology, Sidra Medicine, Doha P.O. Box 26999, Qatar. FAU - Hussain, Khalid AU - Hussain K AUID- ORCID: 0000-0002-5480-7112 AD - Division of Endocrinology, Department of Pediatric Medicine, Sidra Medicine, Doha P.O. Box 26999, Qatar. LA - eng GR - QNRF-NPRP 10-6100017-AXX)/qnrf/ PT - Journal Article DEP - 20260105 PL - Switzerland TA - Int J Mol Sci JT - International journal of molecular sciences JID - 101092791 RN - 0 (Basic Helix-Loop-Helix Proteins) RN - 0 (Repressor Proteins) RN - 0 (SIM1 protein, human) SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Male MH - *Basic Helix-Loop-Helix Proteins/genetics/chemistry/metabolism MH - Frameshift Mutation MH - Genetic Predisposition to Disease MH - Models, Molecular MH - Mutation, Missense MH - *Obesity/genetics MH - *Pediatric Obesity/genetics MH - *Repressor Proteins/genetics/chemistry/metabolism PMC - PMC12786438 OTO - NOTNLM OT - Prader-Willi-like syndrome OT - SIM1 OT - early-onset obesity OT - hyperphagia OT - leptin-melanocortin OT - monogenic obesity COIS- The authors declare no conflicts of interest. EDAT- 2026/01/10 06:32 MHDA- 2026/01/10 06:33 PMCR- 2026/01/05 CRDT- 2026/01/10 01:11 PHST- 2025/11/05 00:00 [received] PHST- 2025/12/25 00:00 [revised] PHST- 2025/12/30 00:00 [accepted] PHST- 2026/01/10 06:33 [medline] PHST- 2026/01/10 06:32 [pubmed] PHST- 2026/01/10 01:11 [entrez] PHST- 2026/01/05 00:00 [pmc-release] AID - ijms27010533 [pii] AID - ijms-27-00533 [pii] AID - 10.3390/ijms27010533 [doi] PST - epublish SO - Int J Mol Sci. 2026 Jan 5;27(1):533. doi: 10.3390/ijms27010533. PMID- 41515295 OWN - NLM STAT- MEDLINE DCOM- 20260110 LR - 20260920 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 1 DP - 2026 Jan 5 TI - Physical Activity Determinants Under the Double Burden of Malnutrition: Contrasting Pathways for Underweight and Overweight Chinese Adolescents. LID - 10.3390/nu18010179 [doi] LID - 179 AB - BACKGROUND: Chinese adolescents face a dual burden of malnutrition, yet the weight-status-specific mechanisms underlying physical activity (PA) participation remain underexplored. METHODS: We conducted a cross-sectional study among 1573 adolescents (aged 9-15 years) in Shangrao City, China. Validated scales measured social-ecological factors (family/peer support, physical environment), psychological factors (stage of change, self-efficacy, decisional balance), and PA participation. Data preprocessing utilized full information maximum likelihood to handle missing values. Confirmatory factor analysis was performed to validate the measurement model, followed by multi-group structural equation modeling to analyze pathway configurations across underweight (n = 187), normal-weight (n = 1070), and overweight/obese (n = 316) groups. Mediation effects were tested using bootstrapping with 5000 resamples. RESULTS: Clear weight-specific patterns emerged. Normal-weight adolescents presented a fully functional comprehensive model where PA was predicted by the stage of change (beta = 0.211, p < 0.001), friend support (beta = 0.120, p < 0.001), self-efficacy (beta = 0.092, p < 0.05), and perceived benefits (beta = 0.095, p < 0.01). Underweight adolescents primarily relied on internal readiness driven by stage of change (beta = 0.270, p < 0.001) and self-efficacy (beta = 0.164, p < 0.05), with family support only indirectly influencing participation via psychological mediators. In contrast, overweight/obese adolescents showed a "socially dependent" pattern: friend support directly predicted PA levels (beta = 0.136, p < 0.05), significantly enhanced self-efficacy (beta = 0.370, p < 0.01), and effectively lowered perceived barriers (beta = -0.165, p < 0.05). Additionally, the physical environment strongly impacted perceived benefits (beta = 0.471, p < 0.01) but did not translate into action. CONCLUSIONS: These findings underscore the significant differences in PA determinants across the spectrum of malnutrition, necessitating targeted public health interventions to support the Healthy China 2030 initiative. FAU - Yao, Liying AU - Yao L AD - School of Physical Education and Sport Science, Guangzhou University, Guangzhou 510006, China. AD - Exercise and Sports Science Programme, School of Health Sciences, University Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia. FAU - Jia, Shuaishuai AU - Jia S AUID- ORCID: 0000-0003-1809-9566 AD - Guangzhou Institute of International Finance, Guangzhou University, Guangzhou 510006, China. FAU - Lv, Xiaochang AU - Lv X AD - School of Physical Education and Sport Science, Guangzhou University, Guangzhou 510006, China. FAU - Dai, Yongguan AU - Dai Y AD - School of Physical Education and Sport Science, Guangzhou University, Guangzhou 510006, China. FAU - Kueh, Yee Cheng AU - Kueh YC AUID- ORCID: 0000-0003-2125-7297 AD - Biostatistics and Research Methodology Unit, School of Medical Sciences, University Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia. FAU - Xu, Jinfu AU - Xu J AD - Journal Center, Guangzhou Sport University, Guangzhou 510500, China. FAU - Cong, Jianqiu AU - Cong J AD - College of Physical Education, Kaili University, Kaili 556011, China. FAU - Kuan, Garry AU - Kuan G AD - Exercise and Sports Science Programme, School of Health Sciences, University Sains Malaysia, Kubang Kerian 16150, Kelantan, Malaysia. LA - eng GR - 24ATY001/National Office for Philosophy and Social Sciences/ PT - Journal Article DEP - 20260105 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - Chinese people SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - *Exercise/psychology MH - *Thinness/psychology/epidemiology MH - Cross-Sectional Studies MH - China/epidemiology MH - Child MH - *Overweight/psychology/epidemiology MH - Self Efficacy MH - *Malnutrition/psychology/epidemiology MH - Social Support MH - East Asian People PMC - PMC12788145 OTO - NOTNLM OT - Social-Ecological Model OT - Transtheoretical Model OT - body mass index OT - multi-group structural equation modeling OT - precision public health COIS- The authors declare no conflicts of interest. EDAT- 2026/01/10 06:32 MHDA- 2026/01/10 06:33 PMCR- 2026/01/05 CRDT- 2026/01/10 01:05 PHST- 2025/12/07 00:00 [received] PHST- 2025/12/29 00:00 [revised] PHST- 2026/01/03 00:00 [accepted] PHST- 2026/01/10 06:33 [medline] PHST- 2026/01/10 06:32 [pubmed] PHST- 2026/01/10 01:05 [entrez] PHST- 2026/01/05 00:00 [pmc-release] AID - nu18010179 [pii] AID - nutrients-18-00179 [pii] AID - 10.3390/nu18010179 [doi] PST - epublish SO - Nutrients. 2026 Jan 5;18(1):179. doi: 10.3390/nu18010179. PMID- 41515281 OWN - NLM STAT- MEDLINE DCOM- 20260110 LR - 20260114 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 1 DP - 2026 Jan 4 TI - AUT-MENU Project: A Bicentric Intervention Study to Improve the Meal Acceptance of Subjects with Autism Spectrum Disorder. LID - 10.3390/nu18010165 [doi] LID - 165 AB - Background/Objectives: Individuals with Autism Spectrum Disorder (ASD) often exhibit low dietary diversity due to Food Selectivity (FS), leading to various forms of malnutrition, such as obesity and/or micronutrient deficiencies. The main objective of the AUT-MENU project is to improve meal acceptance among individuals with ASD. A secondary goal is to evaluate the effectiveness of a nutrition education course for parents of enrolled participants to reduce FS. Methods: The study is a bicentric intervention conducted in three care centers (Northern area, Pavia and Milan) and one secondary school (Southern area, Rome), involving individuals with ASD aged 3 to 35 years. The study consists of an observational phase (T0) and an intervention phase (T1). At T0, biographical data, clinical characteristics, and dietary patterns of participants are collected. Based on T0 findings and existing nutritional recommendations for ASD individuals, targeted menus are developed and tested. At T1, the same assessment tools used at T0 will be applied to evaluate intervention effects. Additionally, a nutrition education course for caregivers will be implemented between T0 and T1, with a pre- and post-course knowledge questionnaire to assess its effectiveness. Results: This paper reports the results from the care centers in the Northern Area. Conclusions: Menu adaptations, developed according to individual preferences and nutritional guidelines, did not significantly modify food consumption but were well tolerated, allowing for an improvement in the nutritional profile of meals without reducing acceptability. These findings support the feasibility of implementing tailored menu strategies in collective catering for individuals with ASD. FAU - Conti, Maria Vittoria AU - Conti MV AUID- ORCID: 0000-0002-8120-7091 AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Breda, Chiara AU - Breda C AUID- ORCID: 0009-0008-1828-9021 AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Zambon, Ilaria AU - Zambon I AUID- ORCID: 0009-0003-4926-738X AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Basilico, Sara AU - Basilico S AUID- ORCID: 0000-0001-6860-6429 AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. FAU - Ruggeri, Stefania AU - Ruggeri S AUID- ORCID: 0000-0003-0032-7567 AD - Research Centre for Food and Nutrition-CREA, Via Ardeatina, 546, 00178 Roma, Italy. FAU - Scalvedi, Maria Luisa AU - Scalvedi ML AUID- ORCID: 0000-0003-4129-7341 AD - Research Centre for Food and Nutrition-CREA, Via Ardeatina, 546, 00178 Roma, Italy. FAU - Antonazzi, Francesca AU - Antonazzi F AD - Research Centre for Food and Nutrition-CREA, Via Ardeatina, 546, 00178 Roma, Italy. FAU - Cena, Hellas AU - Cena H AUID- ORCID: 0000-0002-5752-6199 AD - Laboratory of Dietetics and Clinical Nutrition, Department of Public Health, Experimental and Forensic Medicine, University of Pavia, 27100 Pavia, Italy. AD - Clinical Nutrition Unit, Istituti Clinici Scientifici Maugeri Istituto di Ricovero e Cura a Carattere Scientifico, 27100 Pavia, Italy. AD - Italian Institute for Planetary Health, 20156 Milan, Italy. LA - eng GR - F13C22001210007/This research was funded under the National Recovery and Resilience Plan (NRRP), Mission 4 Component 2 Investment 1.3 - Call for tender No. 341 of 15 March 2022 of Italian Ministry of University and Research funded by the European Union - NextGenerationEU/ PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20260104 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Autism Spectrum Disorder/psychology MH - Child MH - Adolescent MH - Child, Preschool MH - Adult MH - Male MH - Young Adult MH - Female MH - *Meals/psychology MH - *Food Preferences/psychology MH - Parents/education MH - *Feeding Behavior MH - Italy MH - *Menu Planning PMC - PMC12787928 OTO - NOTNLM OT - autism spectrum disorder OT - collective catering OT - food selectivity OT - nutrition OT - parent training COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2026/01/10 06:32 MHDA- 2026/01/10 06:33 PMCR- 2026/01/04 CRDT- 2026/01/10 01:05 PHST- 2025/12/05 00:00 [received] PHST- 2025/12/22 00:00 [revised] PHST- 2025/12/30 00:00 [accepted] PHST- 2026/01/10 06:33 [medline] PHST- 2026/01/10 06:32 [pubmed] PHST- 2026/01/10 01:05 [entrez] PHST- 2026/01/04 00:00 [pmc-release] AID - nu18010165 [pii] AID - nutrients-18-00165 [pii] AID - 10.3390/nu18010165 [doi] PST - epublish SO - Nutrients. 2026 Jan 4;18(1):165. doi: 10.3390/nu18010165. PMID- 41515278 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 1 DP - 2026 Jan 3 TI - Cultural Adaptation and Reliability Testing of the Coeliac Disease Food Attitudes and Behaviours Scale in Brazil. LID - 10.3390/nu18010162 [doi] LID - 162 AB - Background: Coeliac disease (CD) is an autoimmune chronic condition that requires a strict diet without gluten as a single effective treatment. However, adherence to a life-long gluten-free diet (GFD) may promote psychological suffering and disordered eating. The Coeliac Disease Food Attitudes and Behaviours Scale (CD-FAB) is the only instrument specifically designed to evaluate these aspects in individuals with CD. Objective: This study aimed to translate the CD-FAB and test its reliability in the Brazilian population. Methods: The research was conducted in three stages: (i) translation and cultural adaptation of CD-FAB into Brazilian Portuguese; (ii) pretesting with Brazilian individuals diagnosed with CD to assess item understanding; and (iii) psychometric evaluation through reproducibility (test-retest reliability) via intraclass correlation coefficient (ICC) and internal consistency via Cronbach's alpha. Results: The CD-FAB was successfully adapted to the Brazilian CD population (Child CD-FAB-BR) and demonstrated strong internal consistency (alpha = 0.807) and an intraclass correlation coefficient (ICC = 0.928). Conclusions: The Brazilian version of CD-FAB proved to be reliable for assessing food attitudes and behaviours in people with CD, potentially allowing for the identification of factors to guide research and clinical practice by driving behaviour-based strategies to improve nutritional education and strategic policies for coeliac patients. Studies with larger and more diverse samples are recommended to provide external validation of the instrument. FAU - Ribeiro, Camila Dos Santos AU - Ribeiro CDS AUID- ORCID: 0000-0002-2770-1603 AD - Department of Nutrition, University Center of the Institute of Higher Education of Brasilia, Brasilia 70200-730, Brazil. FAU - Nakano, Eduardo Yoshio AU - Nakano EY AUID- ORCID: 0000-0002-9071-8512 AD - Department of Statistics, University of Brasilia, Brasilia 70910-900, Brazil. FAU - Zandonadi, Renata Puppin AU - Zandonadi RP AUID- ORCID: 0000-0003-0370-3089 AD - Department of Nutrition, University of Brasilia, Brasilia 70910-900, Brazil. LA - eng GR - Edital 03/2025-n masculine 00193-00001084/2025-17/Fundacao De Apoio a Pesquisa do Distrito Federal-FAP/DF/ PT - Journal Article DEP - 20260103 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Celiac Disease/psychology/diet therapy MH - Brazil MH - Female MH - Reproducibility of Results MH - *Diet, Gluten-Free/psychology MH - Male MH - Psychometrics MH - Adult MH - *Feeding Behavior/psychology MH - Surveys and Questionnaires MH - Adolescent MH - Middle Aged MH - Young Adult MH - Child MH - *Health Knowledge, Attitudes, Practice PMC - PMC12787950 OTO - NOTNLM OT - CD-FAB OT - coeliac disease OT - eating behaviours OT - gluten-free diet OT - questionnaire COIS- The authors declare that they have no conflicts of interest. EDAT- 2026/01/10 06:32 MHDA- 2026/01/10 06:33 PMCR- 2026/01/03 CRDT- 2026/01/10 01:05 PHST- 2025/10/30 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2025/12/25 00:00 [accepted] PHST- 2026/01/10 06:33 [medline] PHST- 2026/01/10 06:32 [pubmed] PHST- 2026/01/10 01:05 [entrez] PHST- 2026/01/03 00:00 [pmc-release] AID - nu18010162 [pii] AID - nutrients-18-00162 [pii] AID - 10.3390/nu18010162 [doi] PST - epublish SO - Nutrients. 2026 Jan 3;18(1):162. doi: 10.3390/nu18010162. PMID- 41515266 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 1 DP - 2026 Jan 1 TI - Parallel Improvement of Both Mental and Cardiometabolic Health in Children and Adolescents with Overweight and Obesity, Following the Implementation of a Multidisciplinary Lifestyle Intervention Program. LID - 10.3390/nu18010150 [doi] LID - 150 AB - Background: Overweight and obesity in childhood and adolescence represent one of the most significant public health challenges of our century. Affected children and adolescents often face psychosocial maladaptation, including low self-esteem, depressive and anxiety symptoms, and behavioral problems, many of which may persist till later in life. The aim of our study was to evaluate the impact of a multidisciplinary, personalized lifestyle intervention program on psychosocial and behavioral symptoms, assessed through standardized psychometric questionnaires, and to investigate their relation with cardiometabolic parameters in children and adolescents with overweight and obesity. Methods: In this prospective cohort study, 537 children and adolescents (6-18 years; females: 52.9%; pubertal: 43.6%) with obesity (n = 44.3%), overweight (n = 33.7%), or normal BMI (n = 22%) participated in a personalized lifestyle intervention program for one year. Clinical and laboratory evaluations, including anthropometric, cardiometabolic, and endocrinologic parameters, as well as psychosocial functioning assessed by the Child Behavior Checklist (CBCL) and Youth Self-Report (YSR), were performed at the beginning and the end of the study. Linear regression analyses identified predictors of psychometric change. Results: At initial evaluation, children and adolescents with obesity displayed a less favorable cardiometabolic profile and greater emotional/conduct difficulties compared to their overweight and normal-BMI counterparts. Following the intervention, significant improvements were observed in BMI, anthropometric and cardiometabolic parameters, as well as reductions in internalizing, externalizing, and total problem scores across multiple CBCL and YSR domains (p < 0.05). The improvements in psychosocial functioning were partly independent of BMI reduction. Linear regression analyses identified cardiometabolic and endocrine markers as significant predictors of psychometric change (p < 0.05), highlighting interactions between metabolic recovery, pubertal hormones, and stress physiology. Conclusions: A personalized, multidisciplinary lifestyle intervention program implemented for 1 year led to parallel improvements in psychosocial and cardiometabolic health in children and adolescents with overweight and obesity. Identification of specific metabolic and endocrine predictors provides novel insights into potential biological mechanisms associated with adiposity, emotional well-being, and neurodevelopment. FAU - Vourdoumpa, Aikaterini AU - Vourdoumpa A AUID- ORCID: 0000-0002-6277-9959 AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. FAU - Paltoglou, George AU - Paltoglou G AUID- ORCID: 0000-0003-4300-7061 AD - Division of Endocrinology, Diabetes and Metabolism, Second Department of Pediatrics, National and Kapodistrian University of Athens, "P. & A. Kyriakou" Children's Hospital, 11527 Athens, Greece. FAU - Manou, Maria AU - Manou M AUID- ORCID: 0000-0002-9584-0373 AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. FAU - Koutaki, Diamanto AU - Koutaki D AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. FAU - Kassari, Penio AU - Kassari P AUID- ORCID: 0000-0003-2464-1825 AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. AD - Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece. FAU - Papadopoulou, Marina AU - Papadopoulou M AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. FAU - Kolaitis, Gerasimos AU - Kolaitis G AD - Department of Child Psychiatry, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. FAU - Charmandari, Evangelia AU - Charmandari E AUID- ORCID: 0000-0002-0851-6998 AD - Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, National and Kapodistrian University of Athens Medical School, 'Aghia Sophia' Children's Hospital, 11527 Athens, Greece. AD - Center of Clinical, Experimental Surgery and Translational Research, Biomedical Research Foundation of the Academy of Athens, 11527 Athens, Greece. LA - eng GR - with the promotional phrase "LoseWeight-Gain Life" (MIS 370545)/(i) National Strategic Reference Framework (NSRF) 2007-2013 under the operational program "Human Resources Development" (EP.AN.A.D) 2007-2013 and was co-funded by the European Social Fund (ESF) and national funding/ GR - (project code: T1EDK-01386, MIS: 5030543, acronym: PEDOBESITY)/(ii) the European Regional Development Fund of the European Union and Greek national funds through the operational program "Competitiveness, Entrepreneurship, and Innovation" (EPA-nEK 2014-2020), under the call RESEARCH-CREATE-INNOVATE/ PT - Journal Article DEP - 20260101 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - Female MH - Child MH - Male MH - Prospective Studies MH - *Mental Health MH - *Pediatric Obesity/psychology/therapy MH - *Life Style MH - Body Mass Index MH - *Overweight/psychology/therapy MH - Psychometrics MH - Risk Reduction Behavior PMC - PMC12787964 OTO - NOTNLM OT - CBCL OT - YSR OT - cardiometabolic health OT - lifestyle intervention OT - mental health OT - obesity OT - overweight OT - youth COIS- The authors declare no conflicts of interest. The funding sources played no part in the study's design, data collection, analysis, or interpretation, the drafting of the manuscript, or the decision to publish the findings. EDAT- 2026/01/10 06:31 MHDA- 2026/01/10 06:32 PMCR- 2026/01/01 CRDT- 2026/01/10 01:05 PHST- 2025/11/20 00:00 [received] PHST- 2025/12/22 00:00 [revised] PHST- 2025/12/25 00:00 [accepted] PHST- 2026/01/10 06:32 [medline] PHST- 2026/01/10 06:31 [pubmed] PHST- 2026/01/10 01:05 [entrez] PHST- 2026/01/01 00:00 [pmc-release] AID - nu18010150 [pii] AID - nutrients-18-00150 [pii] AID - 10.3390/nu18010150 [doi] PST - epublish SO - Nutrients. 2026 Jan 1;18(1):150. doi: 10.3390/nu18010150. PMID- 41515217 OWN - NLM STAT- MEDLINE DCOM- 20260110 LR - 20260920 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 1 DP - 2025 Dec 27 TI - Supervised 16-Week Multicomponent Exercise Training Programme for 18-55-Year-Old People Living with and Beyond Cancer-CONSORT 2025-Based Study Protocol of the Pilot Onco-Move Randomized Controlled Trial. LID - 10.3390/nu18010100 [doi] LID - 100 AB - Despite evidence that exercise improves treatment outcomes, most people living with and beyond cancer (PLWBC) are insufficiently physically active. To address this challenge the Onco-Move Improvement of psychophysical fitness in adult cancer survivors pilot randomized controlled trial aims to investigate the 7-month effects of a 16-week supervised, multicomponent exercise programme on PLWBC adults aged 18-55. The study will include 40 participants currently undergoing cancer treatment or up to 5 years post-treatment with different types of cancer, who will be randomly assigned to the experimental or the control group. The exercise programme will take place three times a week for 16 weeks. We hypothesize that the Onco-Move exercise programme will improve participants' quality of life, sexual function, and stress-response strategies, as well as their nutrition, physical functions, and body composition. We also expect to observe physiological changes related to the intervention influencing inflammation, metabolism, muscle adaptation, and cellular aging. The Onco-Move exercise programme, once validated, has the potential to be implemented in oncological non-governmental organizations (NGOs) and hospitals in Poland and Spain, among others, as a feasible, effective, and safe non-pharmacological aid for cancer patients and survivors. FAU - Wieczorek-Przybylo, Marzena AU - Wieczorek-Przybylo M AUID- ORCID: 0000-0003-3052-0130 AD - Department of Psychology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland. FAU - Lachowicz, Milena AU - Lachowicz M AUID- ORCID: 0000-0002-8402-0564 AD - Department and Clinic of Oncology and Radiotherapy, Medical University of Gdansk, 80-210 Gdansk, Poland. FAU - Tomczyk, Maja AU - Tomczyk M AUID- ORCID: 0000-0002-4257-6417 AD - Department of Biochemistry, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland. FAU - Kowalska, Agnieszka AU - Kowalska A AUID- ORCID: 0009-0009-7886-6801 AD - Department of Biochemistry, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland. FAU - Sprengel, Mateusz AU - Sprengel M AUID- ORCID: 0009-0009-4814-084X AD - Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland. FAU - Szczubelek, Jakub AU - Szczubelek J AD - Independent Researcher, 80-000 Gdansk, Poland. FAU - Niedzwiecki, Michal AU - Niedzwiecki M AD - Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland. FAU - Barton, Wojciech AU - Barton W AUID- ORCID: 0009-0007-0913-0935 AD - Department of Physiology, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland. FAU - Zyborowicz, Bartlomiej AU - Zyborowicz B AD - Independent Researcher, 80-000 Gdansk, Poland. FAU - Jimenez-Pavon, David AU - Jimenez-Pavon D AUID- ORCID: 0000-0002-8977-4744 AD - MOVE-IT Research Group, Department of Physical Education, Faculty of Education Sciences and Biomedical Research Innovation Institute of Cadiz, University of Cadiz, 11519 Cadiz, Spain. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20251227 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Pilot Projects MH - Quality of Life MH - Adult MH - *Exercise Therapy/methods MH - *Neoplasms/therapy/psychology MH - Middle Aged MH - *Cancer Survivors/psychology MH - Adolescent MH - Male MH - Young Adult MH - Female MH - Randomized Controlled Trials as Topic MH - *Exercise MH - Body Composition PMC - PMC12787456 OTO - NOTNLM OT - cancer OT - cancer exercise OT - cancer survivors OT - exercise OT - exercise programmes OT - physical activity interventions OT - quality of life COIS- The authors declare that they have no conflicts of interest. EDAT- 2026/01/10 06:32 MHDA- 2026/01/10 06:33 PMCR- 2025/12/27 CRDT- 2026/01/10 01:05 PHST- 2025/11/26 00:00 [received] PHST- 2025/12/24 00:00 [revised] PHST- 2025/12/26 00:00 [accepted] PHST- 2026/01/10 06:33 [medline] PHST- 2026/01/10 06:32 [pubmed] PHST- 2026/01/10 01:05 [entrez] PHST- 2025/12/27 00:00 [pmc-release] AID - nu18010100 [pii] AID - nutrients-18-00100 [pii] AID - 10.3390/nu18010100 [doi] PST - epublish SO - Nutrients. 2025 Dec 27;18(1):100. doi: 10.3390/nu18010100. PMID- 41515183 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 1 DP - 2025 Dec 25 TI - Understanding the Interplay of Maternal Mental Health, Social Support, and Sociodemographic Factors in Promoting Exclusive Breastfeeding in Kinshasa. LID - 10.3390/nu18010065 [doi] LID - 65 AB - BACKGROUND: Exclusive breastfeeding (EBF) is crucial for infant health, and maternal mental health significantly influences breastfeeding practices. This study investigates the relationships among postpartum depression (PPD), maternal dietary diversity, and exclusive breastfeeding in Kinshasa, Democratic Republic of Congo. METHODS: A cross-sectional study was conducted involving 793 mother-child pairs. Data were collected through structured interviews using a validated questionnaire administered by trained enumerators. Statistical analyses included descriptive statistics, chi-square tests, and structural equation modeling (SEM) to evaluate the relationships between maternal and child characteristics and EBF. RESULTS: The proportion of infants in the study sample who were exclusively breastfed was 29.1% (95% CI: 26.0-32.3%). Breastfeeding self-efficacy is positively associated by nutritional advice during pregnancy, with a coefficient of 2.17 (p = 0.003). The husband's support in exclusive breastfeeding positively correlates with breastfeeding self-efficacy (coefficient = 0.23, p < 0.001). A significant negative relationship exists between child age and EBF (coefficient = -0.095, p < 0.001). EBF is positively associated by nutritional advice during pregnancy, with a coefficient of 0.12 (p = 0.016). Child morbidity in the last 2 weeks showed a negative association with EBF practice (coefficient = -0.09, p = 0.014). CONCLUSIONS: This study highlights the multifaceted challenges faced by mothers in Kinshasa regarding exclusive breastfeeding. By prioritizing husband involvement, nutritional counseling, and robust health-system engagement, we can create a more supportive framework for breastfeeding practices. Future research should focus on longitudinal approaches to understand the long-term impacts of these factors on breastfeeding and infant health. Additionally, exploring the potential benefits of integrated maternal health programs that address nutritional needs will be crucial in developing comprehensive support systems for new mothers. FAU - Bukasa, Gloria B AU - Bukasa GB AD - Renaissance University Hospital Centre, Health Zone of Gombe, Kinshasa P.O. Box 11850, Democratic Republic of the Congo. FAU - Kabasubabo, Francis K AU - Kabasubabo FK AUID- ORCID: 0000-0001-8842-688X AD - Patrick Kayembe Research Center, Kinshasa School of Public Health, University of Kinshasa, Kinshasa P.O. Box 11850, Democratic Republic of the Congo. AD - Inserm U1094, IRD UMR270, CHU Limoges, EpiMaCT-Epidemiology of Chronic Diseases in Tropical Zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, University of Limoges, 87000 Limoges, France. FAU - Bondo, Berthold Matondo AU - Bondo BM AUID- ORCID: 0009-0000-9488-5118 AD - Mere et Enfant Barumbu General Referral Hospital, Health Zone of Kinshasa, Kinshasa P.O. Box 11850, Democratic Republic of the Congo. FAU - Batuli, Din-Ar B AU - Batuli DB AUID- ORCID: 0009-0001-8825-3971 AD - General Referral Hospital of Makala, Health Zone of Selembao, Kinshasa P.O. Box 11850, Democratic Republic of the Congo. FAU - Akilimali, Pierre Z AU - Akilimali PZ AUID- ORCID: 0000-0002-3828-6214 AD - Patrick Kayembe Research Center, Kinshasa School of Public Health, University of Kinshasa, Kinshasa P.O. Box 11850, Democratic Republic of the Congo. AD - Department of Nutrition, Kinshasa School of Public Health, University of Kinshasa, Kinshasa P.O. Box 11850, Democratic Republic of the Congo. LA - eng PT - Journal Article DEP - 20251225 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Breast Feeding/psychology/statistics & numerical data MH - Female MH - Democratic Republic of the Congo/epidemiology MH - Adult MH - Cross-Sectional Studies MH - *Social Support MH - *Mental Health MH - Young Adult MH - Infant MH - Pregnancy MH - *Mothers/psychology MH - Depression, Postpartum/psychology/epidemiology MH - Sociodemographic Factors MH - Infant, Newborn MH - Socioeconomic Factors MH - Self Efficacy MH - Surveys and Questionnaires MH - *Maternal Health PMC - PMC12787543 OTO - NOTNLM OT - Kinshasa OT - breastfeeding self-efficacy OT - dietary diversity OT - exclusive breastfeeding COIS- There have been no financial relationships with any organizations that might have an interest in the submitted work in the previous three years or other relationships or activities that could appear to have influenced the work submitted. EDAT- 2026/01/10 06:32 MHDA- 2026/01/10 06:33 PMCR- 2025/12/25 CRDT- 2026/01/10 01:05 PHST- 2025/11/07 00:00 [received] PHST- 2025/12/10 00:00 [revised] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/01/10 06:33 [medline] PHST- 2026/01/10 06:32 [pubmed] PHST- 2026/01/10 01:05 [entrez] PHST- 2025/12/25 00:00 [pmc-release] AID - nu18010065 [pii] AID - nutrients-18-00065 [pii] AID - 10.3390/nu18010065 [doi] PST - epublish SO - Nutrients. 2025 Dec 25;18(1):65. doi: 10.3390/nu18010065. PMID- 41515169 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260920 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 1 DP - 2025 Dec 23 TI - Parental Culinary Skills and Children's Eating Behavior in Brazil: A Cross-Sectional Study. LID - 10.3390/nu18010051 [doi] LID - 51 AB - BACKGROUND: Childhood obesity is a persistent global health challenge, often rooted in early-life dietary patterns shaped within the home environment. OBJECTIVE: To investigate the association between parents' culinary skills, children's eating behavior, and the degree of child involvement in family culinary practices. METHODS: A cross-sectional, analytical study. In the public and private schools in southern Brazil. A total of 205 families with children aged 3 to 13 years participated. Parents or caregivers answered a structured questionnaire on culinary skills and sociodemographic variables. Children's eating behavior was assessed through the validated Brazilian version of the Children's Eating Behaviour Questionnaire (CEBQ). Student's T test was used to compare means, and Pearson's chi-square or Fisher's exact test to compare proportions. Multivariate linear regression was applied to control for potential confounders. Analyses were conducted using SPSS version 27.0 and R software. RESULTS: Most parents (90.7%) reported cooking regularly, and 65.9% involved children in cooking activities. The predominant culinary profile (40%) was classified as "convenience cooking," marked by frequent use of processed ingredients. Healthier parental cooking practices were positively associated with adaptive eating behaviors in children, reflected by lower food fussiness, satiety responsiveness, food responsiveness and food refusal scores and higher enjoyment of food scores domains of the CEBQ. CONCLUSIONS: Despite the high prevalence of routine cooking, convenience-oriented practices remain dominant, reflecting broader sociocultural patterns. Engagement in healthier cooking practices was positively associated with more favorable eating behaviors in children. These findings underscore the importance of promoting culinary education and parental involvement in cooking as strategies to support healthy childhood eating behaviors. FAU - Dos Santos, Thais Souza AU - Dos Santos TS AD - Graduate Program in Pediatrics and Child Health, Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. FAU - Ayala, Camila Ospina AU - Ayala CO AUID- ORCID: 0000-0003-1414-7495 AD - Graduate Program in Pediatrics and Child Health, Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. FAU - Peuckert, Marina Zanette AU - Peuckert MZ AUID- ORCID: 0000-0002-7159-9482 AD - Graduate Program in Pediatrics and Child Health, Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. FAU - Martins, Carla Adriano AU - Martins CA AUID- ORCID: 0000-0002-6902-0232 AD - Collective Feeding Program, Institute of Food and Nutrition, Federal University Rio de Janeiro (UFRJ)-UFRJ-Macae Multidisciplinary Center (CM UFRJ-Macae), Carlos Chagas Filho Avenue, 373, Macae 21941-902, RJ, Brazil. FAU - Feoli, Ana Maria Pandolfo AU - Feoli AMP AUID- ORCID: 0000-0001-7685-8431 AD - Graduate Program in Pediatrics and Child Health, Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. FAU - Bulla, Micaella Bassanesi AU - Bulla MB AD - Graduate Program in Pediatrics and Child Health, Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. FAU - Taffarel, Joao Pedro Soares AU - Taffarel JPS AD - Graduate Program in Pediatrics and Child Health, Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. FAU - Drumond Costa, Caroline Abud AU - Drumond Costa CA AD - Graduate Program in Pediatrics and Child Health, Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS), Ipiranga Avenue, 6681, Porto Alegre 90610-970, RS, Brazil. LA - eng PT - Journal Article DEP - 20251223 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Brazil MH - Female MH - Male MH - *Feeding Behavior/psychology MH - Child MH - *Cooking MH - Child, Preschool MH - *Parents/psychology MH - *Child Behavior MH - Adolescent MH - Surveys and Questionnaires MH - *Parenting MH - Diet, Healthy MH - Food Fussiness PMC - PMC12787823 OTO - NOTNLM OT - children's eating behaviour questionnaire OT - cooking OT - culinary skills OT - food preparation behaviors OT - parenting COIS- The authors report no conflicts of interest regarding the content of this study. EDAT- 2026/01/10 06:31 MHDA- 2026/01/10 06:32 PMCR- 2025/12/23 CRDT- 2026/01/10 01:05 PHST- 2025/09/15 00:00 [received] PHST- 2025/10/16 00:00 [revised] PHST- 2025/10/24 00:00 [accepted] PHST- 2026/01/10 06:32 [medline] PHST- 2026/01/10 06:31 [pubmed] PHST- 2026/01/10 01:05 [entrez] PHST- 2025/12/23 00:00 [pmc-release] AID - nu18010051 [pii] AID - nutrients-18-00051 [pii] AID - 10.3390/nu18010051 [doi] PST - epublish SO - Nutrients. 2025 Dec 23;18(1):51. doi: 10.3390/nu18010051. PMID- 41515167 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 18 IP - 1 DP - 2025 Dec 23 TI - Cross-Cultural Adaptation and Psychometric Properties of the Reward-Based Eating Drive Scale (RED-13) and Its Brief Version (RED-5X) in Three European Countries. LID - 10.3390/nu18010049 [doi] LID - 49 AB - Background and aims: Reward-based eating reflects hedonic drivers of intake, including loss of control, diminished satiety, and preoccupation with food. We translated, adapted and studied the psychometric properties of the 13- and 5-item Reward-Based Eating Drive Scale (RED), for Portugal, Poland and Italy. Methods: A cross-cultural study was conducted with higher education students and general population samples (n = 1999). After translation and cultural adaptation, the RED was administered with food craving items, and collection of sociodemographic and anthropometric data. Factorial structure and measurement invariance were tested using confirmatory factor analysis (CFA), internal consistency with Cronbach's alpha, and convergent validity via correlations with BMI and cravings. Results: CFA supported the expected structures of the RED-13 (three factors) and RED-X5 (unifactorial), with configural and metric invariance across countries and groups. Only partial scalar invariance was achieved for both versions. The RED-13 showed good to excellent internal consistency for total scores (0.868 6 h/week) athletes. CMR was performed using 1.5T scanners to assess ventricular and atrial volumes, myocardial mass, ejection fractions, and feature-tracking strain. We derived 95% prediction intervals stratified by age, sex, and training volume. RESULTS: Of the 575 healthy subjects, 390 were highly trained athletes (22 +/- 6 years, 64% male, 19 +/- 7 training h/week), 102 recreational athletes (23 +/- 6 years, 60% male, 4 +/- 1 training h/week), and 83 sedentary individuals (26 +/- 4 years, 42% male, 1 +/- 1 training h/week). Increasing weekly training hours were associated with larger ventricular volumes, higher myocardial mass, lower ejection fractions, and strain. Compared to sedentary individuals, highly trained athletes had significantly larger left and right ventricular volumes (left ventricular end-diastolic volume index estimate [95% confidence interval]: 0.82 [0.52-1.12], p < 0.001), higher myocardial mass (left ventricular mass index 0.59 [0.31-0.86], p < 0.001), and increased left and right atrial volumes, even after adjusting for age, sex, and weekly training hours. We observed a non-uniform dose-response relationship across activity levels, with the most prominent cardiac adaptations occurring in highly trained athletes. Endurance athletes exhibited the most pronounced volumetric changes among the sport types. Finally, we derived stratified prediction intervals to provide CMR reference ranges in young, healthy individuals stratified by age, sex, general activity level, and weekly training hours. CONCLUSION: This work underscores the influence of age, sex, physical activity level, and type of sports on cardiac adaptation. We provide prediction interval-based CMR reference ranges for volumes, mass, ejection fraction, and strain to improve disease discrimination in athletes. CI - Copyright (c) 2026. Published by Elsevier Inc. FAU - Szabo, Liliana AU - Szabo L AD - Semmelweis University, Department of Sports Medicine, Budapest, Hungary; Semmelweis University, Heart and Vascular Center, Budapest, Hungary; William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, UK. FAU - Juhasz, Vencel AU - Juhasz V AD - Semmelweis University, Heart and Vascular Center, Budapest, Hungary; Cardiovascular Imaging Research Center (CIRC), Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States. FAU - Balla, Dorottya AU - Balla D AD - Semmelweis University, Department of Sports Medicine, Budapest, Hungary; Semmelweis University, Heart and Vascular Center, Budapest, Hungary. FAU - Dohy, Zsofia AU - Dohy Z AD - Semmelweis University, Heart and Vascular Center, Budapest, Hungary. FAU - Czimbalmos, Csilla AU - Czimbalmos C AD - Semmelweis University, Heart and Vascular Center, Budapest, Hungary. FAU - Suhai, Ferenc I AU - Suhai FI AD - Semmelweis University, Heart and Vascular Center, Budapest, Hungary. FAU - Toth, Attila AU - Toth A AD - Semmelweis University, Heart and Vascular Center, Budapest, Hungary. FAU - Hirschberg, Kristof AU - Hirschberg K AD - Semmelweis University, Department of Sports Medicine, Budapest, Hungary; Semmelweis University, Heart and Vascular Center, Budapest, Hungary. FAU - Graziano, Francesca AU - Graziano F AD - Semmelweis University, Department of Sports Medicine, Budapest, Hungary; Semmelweis University, Heart and Vascular Center, Budapest, Hungary; Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua, Padua, Italy. FAU - Kiss, Orsolya AU - Kiss O AD - Semmelweis University, Department of Sports Medicine, Budapest, Hungary; Semmelweis University, Heart and Vascular Center, Budapest, Hungary. FAU - Csulak, Emese AU - Csulak E AD - Semmelweis University, Department of Sports Medicine, Budapest, Hungary; Semmelweis University, Heart and Vascular Center, Budapest, Hungary. FAU - Sydo, Nora AU - Sydo N AD - Semmelweis University, Department of Sports Medicine, Budapest, Hungary; Semmelweis University, Heart and Vascular Center, Budapest, Hungary. FAU - Raisi-Estabragh, Zahra AU - Raisi-Estabragh Z AD - William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, UK; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield, London, UK. FAU - Petersen, Steffen E AU - Petersen SE AD - William Harvey Research Institute, NIHR Barts Biomedical Research Centre, Queen Mary University of London, Charterhouse Square, London, UK; Barts Heart Centre, St Bartholomew's Hospital, Barts Health NHS Trust, West Smithfield, London, UK; Health Data Research UK, London, UK. FAU - Merkely, Bela AU - Merkely B AD - Semmelweis University, Department of Sports Medicine, Budapest, Hungary; Semmelweis University, Heart and Vascular Center, Budapest, Hungary. FAU - Vago, Hajnalka AU - Vago H AD - Semmelweis University, Department of Sports Medicine, Budapest, Hungary; Semmelweis University, Heart and Vascular Center, Budapest, Hungary. Electronic address: vago.hajnalka@semmelweis.hu. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260107 PL - England TA - J Cardiovasc Magn Reson JT - Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance JID - 9815616 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Young Adult MH - *Sedentary Behavior MH - Predictive Value of Tests MH - Adolescent MH - *Athletes MH - *Cardiomegaly, Exercise-Induced MH - *Ventricular Function, Left MH - *Magnetic Resonance Imaging, Cine MH - Adaptation, Physiological MH - *Ventricular Remodeling MH - *Ventricular Function, Right MH - Age Factors MH - *Stroke Volume MH - *Atrial Function, Left MH - Global Longitudinal Strain MH - *Magnetic Resonance Imaging MH - Time Factors MH - *Cardiac Volume PMC - PMC13199982 OTO - NOTNLM OT - Athlete's heart OT - Cardiac magnetic resonance OT - Cardiac remodeling OT - Feature tracking OT - Sports adaptation COIS- Declaration of competing interests S.E.P. provides consultancy to Circle Cardiovascular Imaging Inc., Calgary, Alberta, Canada. The other authors declare no conflicts of interest. EDAT- 2026/01/10 00:34 MHDA- 2026/06/15 11:35 PMCR- 2026/01/07 CRDT- 2026/01/09 19:12 PHST- 2025/04/10 00:00 [received] PHST- 2025/11/09 00:00 [revised] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/06/15 11:35 [medline] PHST- 2026/01/10 00:34 [pubmed] PHST- 2026/01/09 19:12 [entrez] PHST- 2026/01/07 00:00 [pmc-release] AID - S1097-6647(26)00003-7 [pii] AID - 102685 [pii] AID - 10.1016/j.jocmr.2026.102685 [doi] PST - ppublish SO - J Cardiovasc Magn Reson. 2026 Summer;28(1):102685. doi: 10.1016/j.jocmr.2026.102685. Epub 2026 Jan 7. PMID- 41512632 OWN - NLM STAT- MEDLINE DCOM- 20260204 LR - 20260722 IS - 1532-1983 (Electronic) IS - 0261-5614 (Linking) VI - 57 DP - 2026 Feb TI - Measuring diet intake in adolescents: Relative validation of an artificial intelligence enhanced, image assisted mobile application. PG - 106568 LID - S0261-5614(25)00348-6 [pii] LID - 10.1016/j.clnu.2025.106568 [doi] AB - BACKGROUND & AIMS: Puberty is a critical period of development during which nutritional exposures are known to shape long-term health and the risk of chronic diseases. Current dietary assessment methods have limitations for use in large cohorts of adolescent populations. We aimed to evaluate the relative validity of Keenoa (not an acronym), an artificial intelligence-enhanced image-assisted mobile application, against the validated Automated Self-Administered 24 h recall (ASA24)-Canada web-based platform, among adolescents in the CHILD Cohort Study. METHODS: Using a randomized crossover design, participants aged 11-15 years old completed three days (two weekdays and one weekend day) of both Keenoa food tracking and ASA24 food recalls. Differences in reported intakes were analyzed using paired t-tests or Wilcoxon signed-rank test and deattenuated correlations by Spearman's coefficient. Agreement and bias were determined using Bland-Altman's test, and inter-quartile cross-classification agreement was assessed using weighted Cohen kappa. RESULTS: This study included 141 participants with a mean age of 12.2 +/- 0.8 years; of them 74 (52.5 %) males; and 88 (62.4 %) identified as Caucasian/White. Mean +/- SD reported energy intakes (kcal/d) were 1976 +/- 451 and 1978 +/- 425, with ASA24 and Keenoa, respectively (P = 0.95). Mean reported macronutrient, iron, and potassium intakes did not significantly differ between tools. Reported fiber intake was higher, while sodium, calcium and vitamin D intakes were lower with Keenoa compared to ASA24 (P values < 0.001-0.025). Deattenuated correlations between tools ranged from r = 0.77 to 1.00 (all p< 0.01) and weighted Cohen kappa scores ranged from 0.22 to 0.42 (all p < 0.001). Among all participants, 121 (85.8 %) and 78 (55.3 %) completed all 3 requested days with Keenoa and ASA24, respectively (P< 0.01). CONCLUSION: The artificial intelligence-enhanced image-assisted Keenoa mobile application showed strong to moderate relative validity against ASA24 for energy, macronutrient, potassium and iron intakes. Vitamin D, calcium, fiber and sodium showed limited relative agreement based on mean differences. This novel tool may facilitate dietary assessment and reduce attrition bias in cohort studies. Future validation using objective biomarker measures will help establish true validity. CI - Copyright (c) 2025 The Author(s). Published by Elsevier Ltd.. All rights reserved. FAU - Moyen, Audrey AU - Moyen A AD - Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada; School of Human Nutrition, McGill University, Montreal, QC, Canada; Research Institute of the McGill University Health Centre, Montreal, QC, Canada. FAU - Rossi, Antonio AU - Rossi A AD - Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada. FAU - Hart, Maurya AU - Hart M AD - Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada. FAU - Simons, Elinor AU - Simons E AD - Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada. FAU - Mandhane, Piushkumar J AU - Mandhane PJ AD - Department of Pediatrics, University of Alberta, Edmonton, AB, Canada. FAU - Moraes, Theo J AU - Moraes TJ AD - Department of Pediatrics, The Hospital of Sick Children, Translational Medicine Program, Toronto, ON, Canada. FAU - Azad, Meghan B AU - Azad MB AD - Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada. FAU - Turvey, Stuart E AU - Turvey SE AD - Department of Pediatrics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada. FAU - Subbarao, Padmaja AU - Subbarao P AD - Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada; Department of Pediatrics, The Hospital of Sick Children, Translational Medicine Program, Toronto, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada. FAU - Tessier, Anne-Julie AU - Tessier AJ AD - Department of Nutrition, Faculty of Medicine, Universite de Montreal, Montreal, QC, Canada; EPIC Center, Montreal Heart Institute, Montreal QC, Canada; Institut de Valorisation des Donnees (IVADO), Montreal, QC, Canada; Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, United States. Electronic address: anne-julie.tessier@umontreal.ca. FAU - Miliku, Kozeta AU - Miliku K AD - Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada; Department of Medicine, McMaster University, Hamilton, ON, Canada. Electronic address: kozeta.miliku@utoronto.ca. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Validation Study DEP - 20260103 PL - England TA - Clin Nutr JT - Clinical nutrition (Edinburgh, Scotland) JID - 8309603 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Child MH - *Artificial Intelligence MH - *Mobile Applications MH - Cross-Over Studies MH - *Diet/statistics & numerical data MH - *Nutrition Assessment MH - Diet Records MH - Reproducibility of Results MH - Energy Intake MH - Mental Recall MH - *Diet Surveys/methods OTO - NOTNLM OT - Automated self-administered 24 h recall OT - Dietary assessment OT - Dietary intake OT - Food diary OT - Food record OT - Keenoa COIS- Conflict of interest PM reported receiving grant funding from the Women's and Children's Health Research Institute, the Canadian Institute for Health Research (CIHR), the Public Health Agency of Canada, and Alberta Health and personal fees from the European Society of Clinical Microbiology and Infectious Disease outside the submitted work and a leadership role at Alberta Health Services. TJM reported receiving grant funding from CIHR, Cystic Fibrosis Canada, and the Physicians' Services Incorporated Foundation for other projects outside the submitted work. PS holds a Tier 1 Canada Research Chair in Pediatric Asthma and Lung Health. S.E.T. holds a Tier 1 Canada Research Chair in Pediatric Precision Health and the Aubrey J. Tingle Professor of Pediatric Immunology. MBA holds a Canada Research Chair in Early Nutrition and the Developmental Origins of Health and Disease. AJT participated in the development of the Keenoa app and is the cofounder. KM reported receiving grant funding from CIHR and the Heart and Stroke Foundation. EDAT- 2026/01/10 00:34 MHDA- 2026/02/05 00:30 CRDT- 2026/01/09 18:07 PHST- 2025/09/04 00:00 [received] PHST- 2025/12/09 00:00 [revised] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/02/05 00:30 [medline] PHST- 2026/01/10 00:34 [pubmed] PHST- 2026/01/09 18:07 [entrez] AID - S0261-5614(25)00348-6 [pii] AID - 10.1016/j.clnu.2025.106568 [doi] PST - ppublish SO - Clin Nutr. 2026 Feb;57:106568. doi: 10.1016/j.clnu.2025.106568. Epub 2026 Jan 3. PMID- 41512516 OWN - NLM STAT- MEDLINE DCOM- 20260602 LR - 20260626 IS - 1753-6405 (Electronic) IS - 1326-0200 (Linking) VI - 50 IP - 1 DP - 2026 Feb TI - From evidence synthesis to practical tools: Next-user needs for an implementation-ready evidence base to prevent obesity in young children. PG - 100309 LID - S1326-0200(25)00091-3 [pii] LID - 10.1016/j.anzjph.2025.100309 [doi] AB - OBJECTIVE: To understand next-user (e.g. program planners, service managers) decision-making process and needs and expectations for a child health behaviour evidence base. METHODS: Qualitative descriptive study using semi-structured interviews with next-users in the early years system. Data analyses by qualitative descriptive analysis using a deductive and inductive coding approach. RESULTS: Participants (n=9) described their decision-making process, which varied depending on their organisational context, the desired content from an evidence base (e.g. effectiveness, feasibility) and desired functionality (e.g. online repository or dashboard). CONCLUSIONS: Next-users emphasised the need for practical tools that provide easy access to evidence to enable informed decision-making on initiatives in routine settings. IMPLICATIONS FOR PUBLIC HEALTH: Insights into next-users' decision-making process, evidence needs and functionality preferences can be used to design practical fit-for-purpose tools to facilitate knowledge translation. CI - Copyright (c) 2025 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Johnson, Brittany J AU - Johnson BJ AD - Flinders University, College of Nursing and Health Sciences, Caring Futures Institute, Bedford Park, Australia. Electronic address: brittany.johnson@flinders.edu.au. FAU - Middleton, Georgia AU - Middleton G AD - Flinders University, College of Nursing and Health Sciences, Caring Futures Institute, Bedford Park, Australia. FAU - Hunter, Sarah AU - Hunter S AD - Flinders University, College of Nursing and Health Sciences, Caring Futures Institute, Bedford Park, Australia. FAU - Morgillo, Samantha AU - Morgillo S AD - Flinders University, College of Nursing and Health Sciences, Caring Futures Institute, Bedford Park, Australia. FAU - Brown, Vicki AU - Brown V AD - Deakin Health Economics, Institute for Health Transformation, Deakin University, Geelong, Australia. FAU - Seidler, Anna Lene AU - Seidler AL AD - Universitatsmedizin Rostock, Rostock, Mecklenburg-Western Pomerania, Germany. FAU - Perry, Rebecca AU - Perry R AD - Health Translation SA, Adelaide, Australia. FAU - Hunter, Kylie AU - Hunter K AD - University of Sydney, NHMRC Clinical Trials Centre, Sydney, Australia. FAU - Anderson, Jaqueline AU - Anderson J AD - Preventive Health SA, Population Health Division, Adelaide, Australia. FAU - Perimal-Lewis, Lua AU - Perimal-Lewis L AD - Flinders University, College of Science and Engineering, Bedford Park, Australia. FAU - Golley, Rebecca K AU - Golley RK AD - Flinders University, College of Nursing and Health Sciences, Caring Futures Institute, Bedford Park, Australia. LA - eng PT - Evidence Synthesis PT - Journal Article DEP - 20260108 PL - United States TA - Aust N Z J Public Health JT - Australian and New Zealand journal of public health JID - 9611095 SB - IM MH - Humans MH - Qualitative Research MH - *Decision Making MH - *Pediatric Obesity/prevention & control MH - Female MH - Interviews as Topic MH - Child MH - *Evidence-Based Practice MH - Male MH - Child, Preschool OTO - NOTNLM OT - collaboration OT - decision-making OT - evidence synthesis OT - research-practice gap COIS- Conflicts of interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Brittany Johnson reports financial support was provided by Ian Potter Foundation and Flinders University. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/10 00:34 MHDA- 2026/02/19 01:35 CRDT- 2026/01/09 18:05 PHST- 2025/07/29 00:00 [received] PHST- 2025/10/23 00:00 [revised] PHST- 2025/11/24 00:00 [accepted] PHST- 2026/02/19 01:35 [medline] PHST- 2026/01/10 00:34 [pubmed] PHST- 2026/01/09 18:05 [entrez] AID - S1326-0200(25)00091-3 [pii] AID - 10.1016/j.anzjph.2025.100309 [doi] PST - ppublish SO - Aust N Z J Public Health. 2026 Feb;50(1):100309. doi: 10.1016/j.anzjph.2025.100309. Epub 2026 Jan 8. PMID- 41512429 OWN - NLM STAT- MEDLINE DCOM- 20260609 LR - 20260921 IS - 1873-1244 (Electronic) IS - 0899-9007 (Print) IS - 0899-9007 (Linking) VI - 144 DP - 2026 Apr TI - In defense of the Holman index: Defining fatty acid deficiency. PG - 113060 LID - S0899-9007(25)00377-6 [pii] LID - 10.1016/j.nut.2025.113060 [doi] AB - Essential fatty acid deficiency (EFAD) is a rare but serious condition with significant consequences including delayed growth and development, decreased immune response and reproductive dysfunction, among others. EFAD is of particular concern in vulnerable populations such as preterm infants and those receiving long-term parenteral nutrition (PN). As essential fatty acids (EFAs) must be supplemented in the diet due to the inability to synthesize these endogenously, EFAD develops secondary to inadequate EFA intake. The Holman Index, defined by the ratio of Mead acid to arachidonic acid (triene: tetraene (T:T)) in the plasma, has historically served as the method for diagnosis, with the threshold diagnostic value at >/=0.20. This index is derived from the body's natural metabolic response to EFA deprivation, increasing synthesis of Mead acid, and thus remains broadly applicable across various populations. Concerns regarding the established ratio and alternative use of absolute fatty acid values and profiles have been raised that question the utility of the Holman Index. Although recent developments in fatty acid profiling have allowed for increased precision in measurement and development of population-specific reference ranges, reliability of this data in diagnosing EFAD is controversial given variability amongst different studies and population dietary confounders. Data from animal and human studies have demonstrated that the Holman index has continued to reliably detect EFAD even in the era of new lipid emulsions and technological advancements. The Holman Index remains a vital tool in the diagnosis and monitoring of EFAD, offering consistency and early detection capacity in at-risk populations. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Kang, Juhye AU - Kang J AD - Department of Surgery, Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA. FAU - Watnick, Audrey AU - Watnick A AD - Department of Surgery, Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Fernandes, Djanira AU - Fernandes D AD - Department of Surgery, Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA. FAU - Ruiz-Santana, Valeria AU - Ruiz-Santana V AD - Department of Surgery, Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA. FAU - Puder, Mark AU - Puder M AD - Department of Surgery, Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA. FAU - Gura, Kathleen M AU - Gura KM AD - Department of Pharmacy, Division of Gastroenterology, Hepatology and Nutrition, Boston Children's Hospital, Boston, Massachusetts, USA. Electronic address: Kathleen.gura@childrens.harvard.edu. LA - eng GR - T32 HD104582/HD/NICHD NIH HHS/United States PT - Journal Article PT - Review DEP - 20251210 PL - United States TA - Nutrition JT - Nutrition (Burbank, Los Angeles County, Calif.) JID - 8802712 RN - 0 (Fatty Acids, Essential) RN - 27YG812J1I (Arachidonic Acid) RN - JQS194YH3X (mead acid) RN - FC398RK06S (8,11,14-Eicosatrienoic Acid) SB - IM MH - Humans MH - *Fatty Acids, Essential/deficiency/blood MH - *Arachidonic Acid/blood MH - Parenteral Nutrition/adverse effects MH - *8,11,14-Eicosatrienoic Acid/blood/analogs & derivatives MH - Animals MH - Infant, Newborn MH - Infant, Premature PMC - PMC13085678 MID - NIHMS2156327 OTO - NOTNLM OT - EFAD OT - Essential fatty acids OT - Holman Index OT - Mead acid: arachidonic acid ratio OT - intravenous lipid emulsions OT - parenteral nutrition COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Mark Puder reports a relationship with Fresenius Kabi USA LLC that includes: equity or stocks. Mark Puder reports a relationship with Otsuka Pharmaceutical Co Ltd that includes: consulting or advisory and equity or stocks. Mark Puder reports a relationship with NorthSea Therapeutics BV that includes: consulting or advisory and funding grants. Mark Puder reports a relationship with Alcresta Therapeutics Inc that includes: funding grants. Kathleen M. Gura reports a relationship with Fresenius Kabi USA LLC that includes: equity or stocks. Kathleen M. Gura reports a relationship with Otsuka Pharmaceutical Co Ltd that includes: consulting or advisory and equity or stocks. Kathleen M. Gura reports a relationship with American Society for Parenteral and Enteral Nutrition that includes: board membership and speaking and lecture fees. Kathleen M. Gura reports a relationship with Wolters Kluwer that includes: consulting or advisory. Kathleen M. Gura has patent #US9566260B2 with royalties paid to Boston Children's Hospital. Mark Puder has patent #US9566260B2 with royalties paid to Boston Children's Hospital. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/10 00:34 MHDA- 2026/02/14 05:30 PMCR- 2026/04/16 CRDT- 2026/01/09 18:03 PHST- 2025/09/25 00:00 [received] PHST- 2025/11/28 00:00 [revised] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/02/14 05:30 [medline] PHST- 2026/01/10 00:34 [pubmed] PHST- 2026/01/09 18:03 [entrez] PHST- 2026/04/16 00:00 [pmc-release] AID - S0899-9007(25)00377-6 [pii] AID - 10.1016/j.nut.2025.113060 [doi] PST - ppublish SO - Nutrition. 2026 Apr;144:113060. doi: 10.1016/j.nut.2025.113060. Epub 2025 Dec 10. PMID- 41512427 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 1873-3379 (Electronic) IS - 0891-4222 (Linking) VI - 169 DP - 2026 Feb TI - Sensory profiles and a teacher-mediated classroom intervention for preschool skin-picking behaviours. PG - 105204 LID - S0891-4222(25)00288-4 [pii] LID - 10.1016/j.ridd.2025.105204 [doi] AB - BACKGROUND: Preschool skin-picking is an understudied behaviour that can disrupt self-regulation and participation. Its proposed links to atypical sensory processing highlight the need for classroom-based, sensory-informed support. OBJECTIVE: To compare sensory profiles of preschoolers with skin-picking versus typically developing (TD) peers, pilot a brief teacher-mediated, classroom-embedded sensory programme (feasibility, fidelity, preliminary effectiveness), and explore teacher/parent acceptability in Saudi preschools. METHODS: In a sequential explanatory mixed-methods study, 52 Saudi preschool children (3-6 years) were recruited from six classrooms in Saudi Arabia (45 with skin-picking; 7 typically developing). Measures included the Sensory Profile 2, Preschool Skin-Picking Severity Scale (PSP-SS), and structured observations. A subgroup of 15 children received a 4-week teacher-mediated sensory programme. RESULTS: Children with skin-picking exhibited higher levels of Sensory Seeking and Sensory Sensitivity than TD peers. Within the intervention subgroup, the programme resulted in a large reduction in PSP-SS scores (eta(2)p = .64), with marked decreases during transitions (78 %) and sedentary activities (65 %). Severity correlated with Sensory Seeking (r = .52, 95 % CI [.26-.71]) and Sensory Sensitivity (r = .41, 95 % CI [.12-.64]). Qualitative findings indicated limited prior awareness of the behaviour and strong acceptance of the structured sensory routines. CONCLUSIONS AND RECOMMENDATIONS: Atypical sensory processing-particularly elevated sensory seeking-appears central to preschool skin-picking. A brief, teacher-mediated, classroom-embedded sensory programme showed preliminary feasibility, acceptability, and effectiveness; these findings support integrating sensory-informed screening and routine-based classroom supports during high-risk contexts (e.g., transitions and seated tasks), with referral pathways for non-responders. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Abou-Eid, Naglaa Fathy Sayed Ahmed AU - Abou-Eid NFSA AD - Department of Kindergarten, College of Education, Majmaah University, Al-Majmaah 11952, Saudi Arabia. Electronic address: n.aboueid@mu.edu.sa. LA - eng PT - Journal Article DEP - 20260108 PL - United States TA - Res Dev Disabil JT - Research in developmental disabilities JID - 8709782 SB - IM MH - Humans MH - Child, Preschool MH - Male MH - Child MH - Saudi Arabia MH - Female MH - *Child Behavior/psychology MH - School Teachers MH - *Skin/injuries MH - Pilot Projects MH - Schools OTO - NOTNLM OT - Classroom-embedded practices OT - Mixed-methods design OT - Preschool skin-picking OT - Sensory processing OT - Teacher-mediated intervention COIS- Declaration of Competing Interest The author Declare that he has no conflict of interest EDAT- 2026/01/10 00:34 MHDA- 2026/02/10 01:29 CRDT- 2026/01/09 18:03 PHST- 2025/12/15 00:00 [received] PHST- 2025/12/30 00:00 [revised] PHST- 2025/12/30 00:00 [accepted] PHST- 2026/02/10 01:29 [medline] PHST- 2026/01/10 00:34 [pubmed] PHST- 2026/01/09 18:03 [entrez] AID - S0891-4222(25)00288-4 [pii] AID - 10.1016/j.ridd.2025.105204 [doi] PST - ppublish SO - Res Dev Disabil. 2026 Feb;169:105204. doi: 10.1016/j.ridd.2025.105204. Epub 2026 Jan 8. PMID- 41512254 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1533-4287 (Electronic) IS - 1064-8011 (Linking) VI - 40 IP - 4 DP - 2026 Apr 1 TI - Velocity-Based Strength Assessment in Youth Athletes: Effects of Maturation Stage and Repeated Testing on Reliability. PG - 406-413 LID - 10.1519/JSC.0000000000005331 [doi] AB - Moraga-Maureira, E, Gonzalez, JA, and Garcia-Ramos, A. Velocity-based strength assessment in youth athletes: Effects of maturation stage and repeated testing on reliability. J Strength Cond Res 40(4): 406-413, 2026-Resistance training in youth, once clouded by misconceptions about safety and development, is now widely endorsed for its role in enhancing health, motor performance, and athletic skills-highlighting the need for reliable assessment protocols to guide its implementation. This study aimed to evaluate the reliability of velocity-based strength assessment protocols in youth athletes and to examine how testing frequency (1 to 4 sessions) and maturation stage (pre-/circa- vs. postpeak height velocity [PHV]) influence their consistency. Thirty-four young male athletes-16 pre-/circa-PHV (age = 13.2 +/- 0.8 years) and 18 post-PHV (age = 15.1 +/- 1.0 years)-completed 1 familiarization session followed by 4 identical testing sessions. The testing protocol involved 4 incremental loading conditions during the squat exercise. Velocity values at fixed absolute loads showed acceptable absolute (coefficient of variation [CV] approximately 7.0%) and moderate relative reliability (intraclass correlation coefficient [ICC] approximately 0.67), whereas load-velocity relationship variables demonstrated acceptable absolute (CV approximately 9.1%) and good relative reliability (ICC approximately 0.75). Younger athletes (CV approximately 7.6%) demonstrated reliability indices comparable with those observed in post-PHV athletes (CV approximately 8.3%). Although reliability was acceptable from the first session (CV approximately 9.5%), progressive improvements were observed in subsequent sessions (CV approximately 8.8 and 6.2%). These findings support the use of both velocity at fixed loads and load-velocity profiling in youth athletes, suggesting that these protocols can be reliably implemented from as early as 12 years of age, provided that athletes are adequately familiarized with the procedures. CI - Copyright (c) 2026 National Strength and Conditioning Association. FAU - Moraga-Maureira, Enzo AU - Moraga-Maureira E AD - Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain. FAU - Gonzalez, Jair Aburto AU - Gonzalez JA AD - Human Performance Laboratory, Altorendimientocl, Nutrition and Performance Center, Santiago de Chile, Chile; and. FAU - Garcia-Ramos, Amador AU - Garcia-Ramos A AD - Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada, Spain. AD - Department of Sports Sciences and Physical Conditioning, Faculty of Education, Universidad Catolica de la Santisima Concepcion, Concepcion, Chile. LA - eng PT - Journal Article DEP - 20260112 PL - United States TA - J Strength Cond Res JT - Journal of strength and conditioning research JID - 9415084 SB - IM MH - Humans MH - Reproducibility of Results MH - Adolescent MH - Male MH - *Muscle Strength/physiology MH - *Resistance Training MH - *Exercise Test/methods MH - Athletes MH - Athletic Performance/physiology OTO - NOTNLM OT - force OT - power OT - squat OT - velocity-based training EDAT- 2026/01/09 18:31 MHDA- 2026/03/24 12:36 CRDT- 2026/01/09 16:22 PHST- 2026/03/24 12:36 [medline] PHST- 2026/01/09 18:31 [pubmed] PHST- 2026/01/09 16:22 [entrez] AID - 00124278-990000000-00898 [pii] AID - 10.1519/JSC.0000000000005331 [doi] PST - ppublish SO - J Strength Cond Res. 2026 Apr 1;40(4):406-413. doi: 10.1519/JSC.0000000000005331. Epub 2026 Jan 12. PMID- 41511618 OWN - NLM STAT- MEDLINE DCOM- 20260224 LR - 20261009 IS - 0973-7693 (Electronic) IS - 0019-5456 (Linking) VI - 93 IP - 3 DP - 2026 Mar TI - Clinical Signs of Circulatory Impairment/Shock in Children: A Prospective Observational Study. PG - 239-246 LID - 10.1007/s12098-025-05870-7 [doi] AB - OBJECTIVES: To evaluate the diagnostic accuracy and predictive ability of various clinical signs of shock for identifying children requiring immediate intervention. METHODS: The authors conducted this prospective study (2019-2023) in children aged 2 mo to 85%) with a diagnostic odds ratio of 38.8 (95% CI: 27.2, 55). Tachycardia and capillary refill time (CRT) > 2 s demonstrated sensitivity and specificity of > 70% each. In children with malnutrition and severe anemia, hypotension and coma were the strongest predictors of shock. Using Classification and Regression Tree (CART) analysis, the authors developed a model and validated it in internal and external datasets. Three primary scenarios emerged in the CART analysis, comprising of a combination of feeble pulses, tachypnea, hypotension and/or cool peripheries. CONCLUSIONS: In children presenting with acute illness, presence of feeble pulses was the best predictor of shock followed by tachycardia and prolonged CRT. The CART model, which showed three possible scenarios, needs further validation and may be used as a bedside approach to identify patients with shock requiring interventions. CI - (c) 2026. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation. FAU - Sankar, Jhuma AU - Sankar J AUID- ORCID: 0000-0002-9807-6550 AD - Division of Pediatric Pulmonology and Intensive Care, Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, India. jhumasankar@aiims.edu. FAU - Ismail, Javed AU - Ismail J AD - Pediatric Intensive Care Unit, NMC Royal Hospital Khalifa City, Abu Dhabi, UAE. FAU - Kamal, Vineet Kr AU - Kamal VK AD - Department of Biostatistics, All India Institute of Medical Sciences (AIIMS), Kalyani, West Bengal, India. FAU - Av, Lalitha AU - Av L AD - Department of Pediatrics, St. Johns Medical College and Research Institute, Bengaluru, Karnataka, India. FAU - Kumar, Banothu Kiran AU - Kumar BK AD - Department of Pediatrics, PGIMER, Dr. Ram Manohar Lohia Hospital, New Delhi, India. FAU - Jaravta, Kanika AU - Jaravta K AD - Division of Pediatric Pulmonology and Intensive Care, Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, India. FAU - Chaudhary, Pankaj AU - Chaudhary P AD - Division of Pediatric Pulmonology and Intensive Care, Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, India. FAU - Kabra, S K AU - Kabra SK AD - Division of Pediatric Pulmonology and Intensive Care, Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, India. FAU - Lodha, Rakesh AU - Lodha R AD - Division of Pediatric Pulmonology and Intensive Care, Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, India. LA - eng GR - EEQ/2018/000819/DST/ PT - Journal Article PT - Observational Study PT - Research Support, Non-U.S. Gov't DEP - 20260109 PL - India TA - Indian J Pediatr JT - Indian journal of pediatrics JID - 0417442 SB - IM MH - Humans MH - Prospective Studies MH - *Shock/diagnosis/therapy/physiopathology MH - Female MH - Infant MH - Child, Preschool MH - Male MH - Child MH - Sensitivity and Specificity MH - Adolescent MH - Anemia/complications OTO - NOTNLM OT - Children OT - Clinical signs OT - Fluid bolus OT - Impaired circulation OT - Shock COIS- Declarations. Conflict of Interest: None. EDAT- 2026/01/09 13:34 MHDA- 2026/02/24 18:45 CRDT- 2026/01/09 11:57 PHST- 2025/03/22 00:00 [received] PHST- 2025/11/05 00:00 [accepted] PHST- 2026/02/24 18:45 [medline] PHST- 2026/01/09 13:34 [pubmed] PHST- 2026/01/09 11:57 [entrez] AID - 10.1007/s12098-025-05870-7 [pii] AID - 10.1007/s12098-025-05870-7 [doi] PST - ppublish SO - Indian J Pediatr. 2026 Mar;93(3):239-246. doi: 10.1007/s12098-025-05870-7. Epub 2026 Jan 9. PMID- 41511592 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20260916 IS - 2520-8721 (Electronic) IS - 1109-3099 (Linking) VI - 25 IP - 2 DP - 2026 Jun TI - Association between serum 25-hydroxyvitamin D level and sex steroid hormone among 6-19-year old children and adolescents based on NHANES 2013-2016 data. PG - 673-683 LID - 10.1007/s42000-025-00748-x [doi] AB - INTRODUCTION: Recent pediatric growth research is increasingly examining serum 25(OH)D and sex hormone interactions. While 25(OH)D is crucial for regulation of skeletal health and calcium-phosphorus homeostasis, sex hormones direct pubertal onset and maturation. Given that emerging evidence has revealed intricate 25(OH)D-sex hormone interplay in child development, the current research evaluates potential correlations of sex hormone profiles with 25(OH)D among 6-19-year old children and adolescents. MATERIALS AND METHODS: This cross-sectional study utilized 2013-2016 NHANES data. Participants aged 6-19 years with complete serum 25(OH)D and sex hormone measurements were included. Multivariable regression with subgroup stratification examined independent 25(OH)D-sex hormone relationships. RESULTS: The study enrolled 3,789 participants in the final cohort, averaging 12.3 +/- 4.0 years of age, 50.62% being male and 49.37% female. Significant positive correlations were observed between 25(OH)D concentrations and sex hormone-binding globulin (SHBG) and the testosterone-to-estradiol ratio (TT/E2) in both sexes. Conversely, 25(OH)D demonstrated inverse associations with the free androgen index (FAI) and estradiol (E2) in males, while negatively correlating with FAI in females alone. Subgroup analyses revealed differential associations across pubertal stages and body mass index categories. Notably, the 25(OH)D-SHBG relationship exhibited nonlinearity, with piecewise linear regression identifying a J-shaped association in males (threshold: 60.451 nmol/L) and a U-shaped pattern in females (threshold: 68.051 nmol/L). CONCLUSION: These findings demonstrate significant sex-specific associations between 25(OH)D status and sex hormone profiles in the pediatric population. Prospective longitudinal and experimental studies are warranted to validate these observations and elucidate the underlying mechanisms. CI - (c) 2026. The Author(s), under exclusive licence to Hellenic Endocrine Society. FAU - Wang, Yachao AU - Wang Y AD - College of Traditional Chinese Medicine, Changchun University of Chinese Medicine, Changchun, 130117, Jilin, China. FAU - Li, Haibo AU - Li H AD - Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fujian, China. FAU - Luo, Lei AU - Luo L AD - Department of Pediatrics and Neonatal, Hebei General Hospital, Shijiazhuang, China. FAU - Guo, Yinan AU - Guo Y AD - Department of Pediatrics, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, 130000, Jilin, China. yinanguoasdf@163.com. LA - eng GR - 20220204085YY/Jilin Provincial Key Research and Development Plan Project/ PT - Journal Article DEP - 20260109 PL - Switzerland TA - Hormones (Athens) JT - Hormones (Athens, Greece) JID - 101142469 RN - 1406-16-2 (Vitamin D) RN - A288AR3C9H (25-hydroxyvitamin D) RN - 4TI98Z838E (Estradiol) RN - 0 (Sex Hormone-Binding Globulin) RN - 3XMK78S47O (Testosterone) RN - 0 (Gonadal Steroid Hormones) SB - IM MH - Humans MH - Child MH - Female MH - Adolescent MH - *Vitamin D/analogs & derivatives/blood MH - Male MH - Nutrition Surveys MH - Cross-Sectional Studies MH - *Estradiol/blood MH - Young Adult MH - *Sex Hormone-Binding Globulin/metabolism/analysis MH - *Testosterone/blood MH - *Gonadal Steroid Hormones/blood OTO - NOTNLM OT - 25-hydroxyvitamin d [25(OH)D] OT - Children and adolescents OT - National health and nutrition examination survey (NHANES) OT - Sex hormones COIS- Declarations. Clinical trial registration: Not applicable. This study is a secondary analysis of existing NHANES data and does not involve a clinical trial. Ethics and consent to participate: Ethics approval for this study were not required as it constitutes a secondary analysis of existing data for which no additional institutional review board (IRB) review was required. The original NHANES protocol was reviewed and approved by the Ethics Review Committee of the National Center for Health Statistics (NCHS). Written informed consent was obtained from all survey participants prior to data collection. Consent for publication: Not applicable. Competing interests: The authors state that no financial or commercial associations exist that might create real or perceived conflicts of interest regarding this investigation. EDAT- 2026/01/09 13:33 MHDA- 2026/09/16 17:36 CRDT- 2026/01/09 11:51 PHST- 2025/09/12 00:00 [received] PHST- 2025/11/28 00:00 [accepted] PHST- 2026/09/16 17:36 [medline] PHST- 2026/01/09 13:33 [pubmed] PHST- 2026/01/09 11:51 [entrez] AID - 10.1007/s42000-025-00748-x [pii] AID - 10.1007/s42000-025-00748-x [doi] PST - ppublish SO - Hormones (Athens). 2026 Jun;25(2):673-683. doi: 10.1007/s42000-025-00748-x. Epub 2026 Jan 9. PMID- 41511130 OWN - NLM STAT- MEDLINE DCOM- 20260109 LR - 20260121 IS - 1512-0112 (Print) IS - 1512-0112 (Linking) IP - 368 DP - 2025 Nov TI - ACANTHOSIS NIGRICANS, OBESITY, AND DIABETES RISK FACTORS: A COMMUNITY-BASED MULTICENTER STUDY IN QASSIM, SAUDI ARABIA. PG - 98-111 AB - BACKGROUND: Acanthosis nigricans (AN) is a cutaneous marker of insulin resistance and obesity, serving as an early warning sign for type 2 diabetes mellitus (T2DM). Limited epidemiological data exist on the prevalence of AN among young populations in Saudi Arabia. OBJECTIVE: To determine the prevalence of AN and its association with obesity and diabetes-related risk factors in a community-based sample in Qassim, Saudi Arabia. METHODS: A multicenter cross-sectional study was conducted between February and May 2025 in Qassim. Although the study recruited participants aged >/=10 years, the sample predominantly consisted of adults, and only about one-quarter fell within the WHO-defined youth category (10-24 years). A structured, validated questionnaire was administered to 420 participants. Obesity and AN were assessed using self-report rather than clinical examination, which may introduce misclassification bias. Fasting glucose and HbA1c values were recorded when available; however, laboratory data were only accessible for a small subset of participants and were therefore interpreted cautiously. RESULTS: The mean age of participants was 35.1+/-14.3 years. The overall prevalence of AN was 17.3%, and self-reported obesity was 24.0%. Because laboratory values were available for only a minority, related findings are considered exploratory rather than representative of the total sample. AN was significantly associated with obesity (p=0.005). CONCLUSION: AN was relatively common in this mixed-age population. Given that only a small proportion of participants met the youth definition, results should not be interpreted as representing "young people" exclusively. FAU - Alharbi, M AU - Alharbi M AD - 1Department of Medicine, College of Medicine, Qassim University, Buraydah, Al-Qassim, Saudi Arabia. FAU - Albarrak, R AU - Albarrak R AD - 2Department of General Surgery, King Fahad Specialist Hospital, Buraydah, Qassim, Saudi Arabia. FAU - Alnassar, A AU - Alnassar A AD - 3Qassim University, College of Medicine Buraidah, Saudi Arabia. FAU - Alsweed, K AU - Alsweed K AD - 3Qassim University, College of Medicine Buraidah, Saudi Arabia. FAU - Almutairi, A AU - Almutairi A AD - 4Department of Internal Medicine, Qassim Health Cluster, Qassim, Saudi Arabia. FAU - Albarrak, R AU - Albarrak R AD - 3Qassim University, College of Medicine Buraidah, Saudi Arabia. FAU - Alqurishi, J AU - Alqurishi J AD - 3Qassim University, College of Medicine Buraidah, Saudi Arabia. LA - eng PT - Journal Article PT - Multicenter Study PL - Georgia (Republic) TA - Georgian Med News JT - Georgian medical news JID - 101218222 RN - 0 (Blood Glucose) RN - 0 (Glycated Hemoglobin) SB - IM MH - Humans MH - Saudi Arabia/epidemiology MH - *Acanthosis Nigricans/epidemiology/complications/blood MH - Female MH - Male MH - Adult MH - Risk Factors MH - *Obesity/epidemiology/complications MH - Cross-Sectional Studies MH - Middle Aged MH - *Diabetes Mellitus, Type 2/epidemiology/complications/blood MH - Adolescent MH - Prevalence MH - Child MH - Young Adult MH - Blood Glucose MH - Glycated Hemoglobin/metabolism EDAT- 2026/01/09 13:33 MHDA- 2026/01/09 13:34 CRDT- 2026/01/09 09:03 PHST- 2026/01/09 13:34 [medline] PHST- 2026/01/09 13:33 [pubmed] PHST- 2026/01/09 09:03 [entrez] PST - ppublish SO - Georgian Med News. 2025 Nov;(368):98-111. PMID- 41510933 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1578-1267 (Electronic) IS - 0301-0546 (Linking) VI - 54 IP - 1 DP - 2026 TI - Adult IgE-mediated food allergy: clinical characteristics, predictors of severe reactions, and total IgE cut-off. PG - 145-153 LID - 10.15586/aei.v54i1.1548 [doi] AB - BACKGROUND: Adult immunoglobulin E (IgE)-mediated food allergy (FA) is increasingly recognized, yet it has remained under-characterized, compared with pediatric FA. We described clinical features, diagnostic profiles, predictors of severe reactions and explored a pragmatic total IgE cut-off in an adult cohort. METHOD: We retrospectively reviewed 423 consecutive adults evaluated for suspected IgE-mediated FA at a tertiary center. Demographics, comorbid atopy, index culprit foods, diagnostic testing (skin prick/prick-to-prick, serum-specific IgE, component-resolved diagnostics), laboratory parameters, reaction severity (Brown grade severity), and adrenaline autoinjector (AAI) prescribing were extracted. Group comparisons used chi(2)/Fisher's exact, t-test, or Mann-Whitney U tests. Receiver operating characteristic analysis assessed the discriminative value of total IgE for confirmed FA. Variables associated with Brown grade 3 severity were examined by multivariable logistic regression. RESULTS: FA was confirmed in 79/423 patients (18.7%). Median age was 39.2 years; 71.4% were females. Frequent implicated groups were meat (23.9%), fruit (23.4%), nuts (22.5%), and vegetables (19.4%). Atopy was present in 46.1%; sensitization to mites and pollens occurred in 38.3% and 25.1%, respectively. Compared to non-confirmed cases, confirmed FA showed higher proportions of asthma, non-steroidal anti-inflammatory drug allergy, moderate/severe reactions (Brown grades 2-3 severity), atopy, mite/pollen sensitization, latex-fruit and pollen-fruit syndromes, AAI prescription, and food-dependent exercise-induced anaphylaxis (all P < 0.05). Eosinophil count/percentage and total IgE were also high (all P < 0.05). Total IgE >/=110.5 IU/mL predicted confirmed FA with 64.6% sensitivity and 59.7% specificity (area under curve 0.634; 95% confidence interval [CI]: 0.561-0.706; P = 0.001). In multivariable analysis, the absence of rhinitis and fish/seafood allergy, and the presence of atopy were independently associated with Brown grade 3 severity (model accuracy 84.4%). Overall, AAIs were prescribed in 38.1%, more often when FA was confirmed (66.7% vs 31.7%). CONCLUSIONS: Adult FA in a real-world tertiary cohort is clinically heterogeneous and clusters with respiratory atopy. A total IgE threshold of 110.5 IU/mL offers modest discrimination and should complement, not replace, history and allergen-specific testing. Rhinitis, fish/seafood allergy, and lack of atopy identify patients at higher risk of severe reactions and may guide risk stratification and AAI prescribing. CI - Copyright: Argin O, et al. FAU - Argin, Ozge AU - Argin O AD - Department of Allergy and Immunology, Sureyyapasa Training and Research Hospital, University of Health Sciences, Istanbul, Turkey; ozge_evcn@hotmail.com. FAU - Katran, Zeynep Yegin AU - Katran ZY AD - Department of Allergy and Immunology, Sureyyapasa Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. FAU - Bulut, Ismet AU - Bulut I AD - Department of Allergy and Immunology, Sureyyapasa Training and Research Hospital, University of Health Sciences, Istanbul, Turkey. LA - eng GR - None./ PT - Journal Article DEP - 20260101 PL - Singapore TA - Allergol Immunopathol (Madr) JT - Allergologia et immunopathologia JID - 0370073 RN - 37341-29-0 (Immunoglobulin E) RN - 0 (Allergens) SB - IM MH - Humans MH - Female MH - *Immunoglobulin E/blood/immunology MH - *Food Hypersensitivity/diagnosis/immunology/epidemiology MH - Adult MH - Male MH - Retrospective Studies MH - Severity of Illness Index MH - Middle Aged MH - Allergens/immunology MH - Skin Tests MH - *Anaphylaxis/immunology/diagnosis/epidemiology MH - Young Adult OTO - NOTNLM OT - IgE-mediated OT - ROC OT - adrenaline autoinjector OT - adult food allergy OT - anaphylaxis OT - component-resolved diagnostics OT - risk factors OT - total IgE COIS- The authors had no relevant financial interests to disclose. EDAT- 2026/01/09 13:33 MHDA- 2026/01/09 13:34 CRDT- 2026/01/09 07:44 PHST- 2025/08/11 00:00 [received] PHST- 2025/10/09 00:00 [accepted] PHST- 2026/01/09 13:34 [medline] PHST- 2026/01/09 13:33 [pubmed] PHST- 2026/01/09 07:44 [entrez] AID - 10.15586/aei.v54i1.1548 [doi] PST - epublish SO - Allergol Immunopathol (Madr). 2026 Jan 1;54(1):145-153. doi: 10.15586/aei.v54i1.1548. eCollection 2026. PMID- 41509656 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260109 LR - 20260111 IS - 2589-9864 (Electronic) IS - 2589-9864 (Linking) VI - 33 DP - 2026 Mar TI - Implementation of a ketogenic diet clinic in Mexico: A pilot program in a resource-limited setting. PG - 100842 LID - 10.1016/j.ebr.2025.100842 [doi] LID - 100842 AB - This study describes the implementation and outcomes of the first protocolized Ketogenic Diet Clinic (KDC) in Mexico for pediatric drug-resistant epilepsy (DRE). We conducted a retrospective analysis of 20 patients with DRE who initiated KDT between July 2022 and July 2024 in a multidisciplinary KDC at a public tertiary hospital. All patients were newly started on KDT under a structured protocol; none followed a classic 4:1 ketogenic diet, all received modified regimens. Clinical, nutritional, and socioeconomic data were collected. Seizure outcomes were categorized by percent reduction, and antiseizure medication (ASM) burden was evaluated through changes in cumulative daily dose and ASM count. Hospital admissions were recorded, and caregivers were asked about barriers to implementation. At the first follow-up visit ( approximately 3 months), with complete data for all 20 patients, 10/20 (50 %) achieved >/=50 % seizure reduction and 4/20 (20 %) achieved >/=90 % reduction. Due to staggered recruitment, later visits included fewer patients (n = 18 and n = 14). Among the 14 patients who reached the third visit, 9/14 (64 %) achieved >/=90 % reduction. ASM dose decreased in 12/20 (60 %), and ASM count decreased in 6/20 (30 %). Hospital visits declined from 16 events the prior year to 4 after KDT initiation. Despite cultural, nutritional, educational, and access-related barriers, no patient discontinued the diet, as treatment plans were adapted to maintain feasibility. A structured KDC is feasible and clinically beneficial in a resource-limited setting. Modified KDT regimens reduced seizure burden and treatment intensity, supporting expansion of KDT programs in low-resource contexts. CI - (c) 2025 The Authors. Published by Elsevier Inc. FAU - Chavez-Castillo, Melissa AU - Chavez-Castillo M AD - Pediatric Epilepsy Clinic, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico. FAU - Hurtado-Cuan, Paloma AU - Hurtado-Cuan P AD - Faculty of Medicine, Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, Jalisco, Mexico. FAU - Soto-Blanquel, Maria Alejandra AU - Soto-Blanquel MA AD - Department of Clinical Nutrition, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico. FAU - Jimenez-Ruiz, Amado AU - Jimenez-Ruiz A AD - Department of Neurology, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico. FAU - Gomez-Figueroa, Enrique AU - Gomez-Figueroa E AD - Department of Neurology, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico. FAU - Marquez-Palacios, Rosa AU - Marquez-Palacios R AD - Department of Pediatric Neurology, Hospital Civil de Guadalajara Fray Antonio Alcalde, Guadalajara, Jalisco, Mexico. LA - eng PT - Journal Article DEP - 20251216 PL - United States TA - Epilepsy Behav Rep JT - Epilepsy & behavior reports JID - 101750909 PMC - PMC12775990 OTO - NOTNLM OT - Drug-resistant epilepsy OT - Ketogenic diet therapy OT - Low-income setting OT - Pediatric epilepsy COIS- The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: [Melissa Chavez-Castillo reports a relationship with Stendhal Pharma that includes: speaking and lecture fees. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.]. EDAT- 2026/01/09 07:07 MHDA- 2026/01/09 07:08 PMCR- 2025/12/16 CRDT- 2026/01/09 05:04 PHST- 2025/08/18 00:00 [received] PHST- 2025/12/15 00:00 [revised] PHST- 2025/12/15 00:00 [accepted] PHST- 2026/01/09 07:08 [medline] PHST- 2026/01/09 07:07 [pubmed] PHST- 2026/01/09 05:04 [entrez] PHST- 2025/12/16 00:00 [pmc-release] AID - S2589-9864(25)00102-9 [pii] AID - 100842 [pii] AID - 10.1016/j.ebr.2025.100842 [doi] PST - epublish SO - Epilepsy Behav Rep. 2025 Dec 16;33:100842. doi: 10.1016/j.ebr.2025.100842. eCollection 2026 Mar. PMID- 41507597 OWN - NLM STAT- MEDLINE DCOM- 20260108 LR - 20260121 IS - 1432-1262 (Electronic) IS - 0179-1958 (Print) IS - 0179-1958 (Linking) VI - 41 IP - 1 DP - 2026 Jan 8 TI - Multidimensional impact analysis of interactive video health intervention on quality of life and clinical rehabilitation indicators in patients with early postoperative bowel obstruction: a randomized controlled trial. PG - 19 LID - 10.1007/s00384-025-05051-0 [doi] LID - 19 AB - OBJECTIVE: To investigate the multiple effects of interactive video health intervention on the quality of life and clinical rehabilitation indexes of patients with early intestinal obstruction. METHODS: This study included two phases: (1) questionnaire validation (January 2019-December 2020): 152 patients with early postoperative bowel obstruction were enrolled to develop and test the reliability/validity of the Postoperative Quality of Life Assessment Scale for Early Intestinal Obstruction. (2) Randomized controlled trial (January 2021-January 2025): 310 eligible patients (18-75 years, basic cognitive ability, diagnosed with early postoperative bowel obstruction after abdominal surgery) were randomly assigned to a control group (conventional care: condition monitoring, basic treatment, and non-structured health education, n = 132) or a study group (conventional care plus an interactive video health intervention-5 modular videos covering disease knowledge, rehabilitation, and diet, initiated 24 h post-surgery, n = 178). Outcomes included QoL (via the validated scale), clinical rehabilitation indicators (obstruction relief time, hospitalization duration), electrogastrogram parameters, and gut microbiota diversity (16S rRNA sequencing). RESULTS: The validated QoL scale had good reliability (Cronbach's alpha = 0.821-0.937) and validity (AVE > 0.5, CR > 0.7). In the trial, the study group showed significantly better QoL scores (physiological function: 13.82 +/- 5.67 vs. 22.45 +/- 3.57; total score: 50.60 +/- 6.44 vs. 36.67 +/- 7.93; P < 0.001) and clinical outcomes (hospitalization duration: 8.78 +/- 1.39 vs. 10.13 +/- 1.41 days; P < 0.001) than the control group. The study group also had improved electrogastrogram parameters (e.g., gastric antrum slow-wave amplitude: 194.59 +/- 20.76 vs. 151.34 +/- 21 microV; P < 0.001) and intestinal microbiota evenness (Shannon index: P = 0.0070) compared to the control group. CONCLUSION: The disease-specific QoL scale is valid for assessing patients with early postoperative bowel obstruction. The interactive video health intervention effectively improves their QoL and clinical rehabilitation, providing a feasible clinical tool. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT07258017 (September 24, 2025). CI - (c) 2026. The Author(s). FAU - Yao, Lu AU - Yao L AD - Department of Anesthesia Surgery, The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital.of Changsha), Changsha, 410006, China. FAU - Wu, Di AU - Wu D AD - Department of Anesthesia Surgery, The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital.of Changsha), Changsha, 410006, China. FAU - Liu, Jiefeng AU - Liu J AD - Department of Gastrointestinal Surgery, The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital.of Changsha), Changsha, 410006, China. FAU - Zhang, Xiaoyan AU - Zhang X AD - Department of Anesthesia Surgery, The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital.of Changsha), Changsha, 410006, China. FAU - Zhang, Li AU - Zhang L AD - Department of Nursing, The Fourth Hospital of Changsha (Integrated Traditional Chinese and Western Medicine Hospital.of Changsha), Hunan Province, No. 200, Section 4, Jinxing North Road, Wangcheng District, Changsha, 410006, China. 13187075003@163.com. LA - eng SI - ClinicalTrials.gov/NCT07258017 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260108 PL - Germany TA - Int J Colorectal Dis JT - International journal of colorectal disease JID - 8607899 SB - IM MH - Humans MH - *Quality of Life MH - Female MH - Male MH - Middle Aged MH - Adult MH - Aged MH - *Intestinal Obstruction/rehabilitation/etiology MH - *Postoperative Complications/rehabilitation MH - Young Adult MH - Adolescent MH - Surveys and Questionnaires MH - Reproducibility of Results MH - Treatment Outcome MH - *Video Recording PMC - PMC12783255 OTO - NOTNLM OT - Early postoperative bowel obstruction OT - Interactive video OT - Quality of life OT - Questionnaire validation OT - Randomized controlled trial COIS- Declarations. Ethics approval and consent to participate: This study received ethical approval from The Fourth Hospital of Changsha (No. CSSDSYY-YXLL-SC-2024-02-20). All procedures performed in studies involving human participants were conducted in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. Written informed consent was obtained directly from all patients, with supplementary consent provided by family members to confirm awareness of the study in accordance with institutional ethics requirements. Competing interests: The authors declare no competing interests. EDAT- 2026/01/09 00:26 MHDA- 2026/01/09 00:27 PMCR- 2026/01/08 CRDT- 2026/01/08 23:32 PHST- 2025/06/19 00:00 [received] PHST- 2025/12/04 00:00 [accepted] PHST- 2026/01/09 00:27 [medline] PHST- 2026/01/09 00:26 [pubmed] PHST- 2026/01/08 23:32 [entrez] PHST- 2026/01/08 00:00 [pmc-release] AID - 10.1007/s00384-025-05051-0 [pii] AID - 5051 [pii] AID - 10.1007/s00384-025-05051-0 [doi] PST - epublish SO - Int J Colorectal Dis. 2026 Jan 8;41(1):19. doi: 10.1007/s00384-025-05051-0. PMID- 41507032 OWN - NLM STAT- MEDLINE DCOM- 20260803 LR - 20260803 IS - 1476-8305 (Electronic) IS - 1028-415X (Linking) VI - 29 IP - 8 DP - 2026 Aug TI - A pilot study of amino acid profiles in boys with autism spectrum disorder and their mothers. PG - 948-967 LID - 10.1080/1028415X.2025.2612115 [doi] AB - Autism Spectrum Disorder (ASD) has been linked to metabolic disturbances in prior research. This pilot study explored plasma and urinary amino acid profiles in a cohort of Jordanian boys with ASD (n = 17) and their mothers, comparing them to neurotypical controls (n = 17). Amino acid concentrations were quantified using Amino Acid Analyzer system, which integrates: High-performance liquid chromatography (HPLC); cation exchange chromatography for separation; and post-column ninhydrin derivatization, l. Our analysis revealed preliminary correlations, including a significant association between urinary arginine levels in children with ASD and their mothers (r = 0.52, p = 0.031). Furthermore, distinct amino acid patterns were observed across ASD severity levels. When evaluating individual amino acids as biomarkers, several showed fair diagnostic accuracy (AUC 0.7-0.8) in internally cross-validated ROC analyses. The observed patterns suggest a complex interplay of genetic factors e.g. Potential inheritance of metabolic enzyme variants, environmental influences (e.g. Shared dietary habits or toxin exposures, and physiological adaptations). These findings suggest that amino acid dysregulation may be involved in ASD and warrant further investigation. However, the small sample size necessitates caution, and these results should be validated in larger, more diverse cohorts to assess their generalizability and potential clinical relevance. FAU - Rashaid, Ayat Hussein B AU - Rashaid AHB AD - Department of Chemistry, Faculty of Science and Art, Jordan University of Science and Technology, Irbid, Jordan. FAU - Al-Rabi, Yaqeen Issa AU - Al-Rabi YI AD - Department of Chemistry, Faculty of Science and Art, Jordan University of Science and Technology, Irbid, Jordan. FAU - Nusair, Shreen Deeb AU - Nusair SD AD - Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan. FAU - Bashtawi, Mahmoud Ahmad AU - Bashtawi MA AD - Department of Neuroscience, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan. LA - eng PT - Journal Article DEP - 20260108 PL - England TA - Nutr Neurosci JT - Nutritional neuroscience JID - 100892202 RN - 0 (Amino Acids) RN - 0 (Biomarkers) RN - 94ZLA3W45F (Arginine) SB - IM MH - Humans MH - Male MH - *Autism Spectrum Disorder/blood/urine MH - Pilot Projects MH - *Amino Acids/blood/urine MH - Biomarkers/blood/urine MH - Female MH - *Mothers MH - Child MH - Child, Preschool MH - Arginine/urine MH - Case-Control Studies OTO - NOTNLM OT - Autism spectrum disorder OT - DSM-5 OT - amino acid profiling OT - biomarkers OT - conditionally essential amino acids OT - neurotypical boys OT - nonessential amino acids EDAT- 2026/01/09 00:26 MHDA- 2026/08/03 06:36 CRDT- 2026/01/08 22:03 PHST- 2026/08/03 06:36 [medline] PHST- 2026/01/09 00:26 [pubmed] PHST- 2026/01/08 22:03 [entrez] AID - 10.1080/1028415X.2025.2612115 [doi] PST - ppublish SO - Nutr Neurosci. 2026 Aug;29(8):948-967. doi: 10.1080/1028415X.2025.2612115. Epub 2026 Jan 8. PMID- 41506750 OWN - NLM STAT- MEDLINE DCOM- 20260108 LR - 20260912 IS - 2059-7908 (Print) IS - 2059-7908 (Electronic) IS - 2059-7908 (Linking) VI - 11 IP - 1 DP - 2026 Jan 8 TI - Impact of an integrated parenting and nutrition intervention on growth and development in stunted children at 24 months: evidence from the Stepping Stones programme in rural India. LID - 10.1136/bmjgh-2024-017395 [doi] LID - e017395 AB - OBJECTIVES: This paper examines the differential impact of responsive parenting and nutrition interventions on early child development in stunted versus never-stunted children at 24 months of age in rural India. METHODS: We conducted a secondary analysis of data from Stepping Stones-a cluster randomised controlled trial involving 21 subcentres/clusters allocated to intervention or control group. The intervention comprised home visits, group sessions and community workshops, focusing on responsive parenting and nutrition. Developmental outcomes, cognitive, motor, language and socio-emotional, were assessed at 24 months using validated tools. A mixed-effects regression model with an interaction term was used to estimate effect sizes for stunted and never-stunted children. RESULTS: Among 588 children analysed, 35.9% were stunted at 24 months, and 35 (5.95%) of them exhibited 'early-onset persistent stunting'. The intervention improved cognitive (beta=0.22), motor (beta=0.23), language (beta=0.17) and socio-emotional development (beta=0.23) in never-stunted children compared with those who have not received intervention. For stunted children who have not received the intervention, a development score was lower for all development domains compared with never-stunted children, but not statistically significant (p>0.05). Although the effects differed between stunted and never-stunted children, the interaction effects between intervention and stunting were not statistically significant across all domains (p>0.05), indicating that the intervention's benefits did not significantly differ by stunting status. CONCLUSION: Integrated parenting and nutrition interventions improved developmental outcomes across all domains, regardless of the child's stunting status. These findings support universal application of such programmes, highlighting the need to integrate them into existing child development and nutrition programmes. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY. Published by BMJ Group. FAU - Gaidhane, Abhay AU - Gaidhane A AUID- ORCID: 0000-0002-4814-2695 AD - Department of Community Medicine, Jawaharlal Nehru Medical College, Wardha; Global Health Academy of Nuvance Health, Danbury, CT, USA; Global Consortium Public Health Research, UK; Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. FAU - Telrandhe, Shital AU - Telrandhe S AUID- ORCID: 0000-0002-3638-7724 AD - Centre of Early Childhood Development - Stepping Stones Project, Research and Development, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India shital.telrandhe88@gmail.com. FAU - Holding, Penny AU - Holding P AUID- ORCID: 0000-0002-4159-9115 AD - Centre of Early Childhood Development - Stepping Stones Project, Research and Develoment, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. FAU - Khatib, Mahalaqua Nazli AU - Khatib MN AUID- ORCID: 0000-0001-5875-8277 AD - Department of Physiology, Jawaharlal Nehru Medical College, Wardha; Global Evidence Synthesis Initiative; Division of Evidence Synthesis, School of Epidemiology & Public Health, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. FAU - Patil, Manoj AU - Patil M AUID- ORCID: 0000-0002-7126-5810 AD - Research and Development, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. FAU - Gaidhane, Shilpa AU - Gaidhane S AUID- ORCID: 0000-0002-3012-7438 AD - Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. FAU - Choudhari, Sonali G AU - Choudhari SG AUID- ORCID: 0000-0003-0642-5096 AD - Department of Community Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. FAU - Umate, Roshan AU - Umate R AUID- ORCID: 0000-0002-0378-4723 AD - Centre of Early Childhood Development - Stepping Stones Project, Research and Development, Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. FAU - Saxena, Deepak AU - Saxena D AUID- ORCID: 0000-0003-0563-4259 AD - Indian Institute of Public Health, Gandhinagar, Gujarat, India. FAU - Syed, Zahiruddin Quazi AU - Syed ZQ AUID- ORCID: 0000-0002-1435-899X AD - Department of Community Medicine, Jawaharlal Nehru Medical College, Wardha; South Asia Infant Feeding Research Network (SAIFRN), Global Health Academy of Nuvance Health, Danbury, USA; ITE Research Foundation, Wardha; School of Epidemiology and Public Health; Datta Meghe Institute of Higher Education and Research, Wardha, Maharashtra, India. LA - eng SI - CTRI/CTRI/2017/05/008553 on 15 May 2017 PT - Journal Article PT - Randomized Controlled Trial DEP - 20260108 PL - England TA - BMJ Glob Health JT - BMJ global health JID - 101685275 SB - IM MH - Humans MH - India/epidemiology MH - Male MH - Child, Preschool MH - *Child Development MH - Female MH - *Growth Disorders/prevention & control/epidemiology MH - *Parenting MH - Rural Population MH - Infant MH - Nutritional Status PMC - PMC13059852 OTO - NOTNLM OT - Child health OT - Nutrition OT - Public Health OT - Stunting COIS- Competing interests: None declared. EDAT- 2026/01/09 00:26 MHDA- 2026/01/09 00:27 PMCR- 2026/01/08 CRDT- 2026/01/08 20:42 PHST- 2024/08/30 00:00 [received] PHST- 2025/12/21 00:00 [accepted] PHST- 2026/01/09 00:27 [medline] PHST- 2026/01/09 00:26 [pubmed] PHST- 2026/01/08 20:42 [entrez] PHST- 2026/01/08 00:00 [pmc-release] AID - bmjgh-2024-017395 [pii] AID - 10.1136/bmjgh-2024-017395 [doi] PST - epublish SO - BMJ Glob Health. 2026 Jan 8;11(1):e017395. doi: 10.1136/bmjgh-2024-017395. PMID- 41505945 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 1578-8989 (Electronic) IS - 0025-7753 (Linking) VI - 166 IP - 1 DP - 2026 Jan TI - Metabolic index a non-invasive predictive marker of liver steatosis in patients with Non-Alcoholic Fatty Liver Disease. PG - 107268 LID - S0025-7753(25)00496-8 [pii] LID - 10.1016/j.medcli.2025.107268 [doi] AB - INTRODUCTION AND OBJECTIVES: Determining insulin resistance (IR) is essential to identify subjects at risk for non-alcoholic fatty liver disease (NAFLD). A particular area of interest is the ability to detect patients with NAFLD using non-invasive biomarkers. This study aimed to evaluate the sensitivity, specificity, and predictive value of the metabolic index for detecting NAFLD. MATERIALS AND METHODS: A retrospective study was conducted in adults of both sexes eligible for inclusion were adults of both sexes aged 18 to 85 years with and without NAFLD. Liver steatosis was measured using the controlled attenuation parameter (CAP) through FibroScan(R). The metabolic index was calculated using the formula: Fasting Glucose x TG/HDL-C2. The study was carried out at the Gastrointestinal and Liver Specialty Clinic in Yucatan, Mexico, between January 2014 and November 2020, using a convenience sampling method. In a total of 138 subjects (32 healthy and 106 patients with NAFLD), anthropometric measures and laboratory tests were obtained to determine levels of triglycerides (TG), glucose, total cholesterol (TC), HDL-C, LDL-C, AST, and ALT. RESULTS: The metabolic index showed a specificity of 90,6% (95% CI [80,5-100]), sensitivity of 64.2% (95% CI [55-73,3]), a positive predictive value of 95,8%, a negative predictive value of 43,3%, a positive likelihood ratio of 6,83, and a negative likelihood ratio of 0,40 for detecting NAFLD. CONCLUSION: The metabolic index showed high specificity for detecting NAFLD and could be used in adult patients with suspected NAFLD seen in primary health care. CI - Copyright (c) 2025 Elsevier Espana, S.L.U. All rights reserved. FAU - Lara-Riegos, Julio AU - Lara-Riegos J AD - Laboratorio de Bioquimica y Genetica Molecular, Facultad de Quimica, Universidad Autonoma de Yucatan, Merida, Yucatan, Mexico. Electronic address: julio.lara@correo.uady.mx. FAU - Chi-Cervera, Luis Alberto AU - Chi-Cervera LA AD - Clinica de Especialidades Gastrointestinales y Hepaticas, Christus Muguerza Hospital Faro del Mayab SA de CV, Merida, Yucatan, Mexico. FAU - Montalvo-Gordon, Iaarah AU - Montalvo-Gordon I AD - Clinica de Especialidades Gastrointestinales y Hepaticas, Christus Muguerza Hospital Faro del Mayab SA de CV, Merida, Yucatan, Mexico. FAU - Azcorra-Perez, Hugo AU - Azcorra-Perez H AD - Centro de Investigaciones Silvio Zavala, Universidad Modelo, Merida, Mexico. FAU - Torres-Romero, Julio AU - Torres-Romero J AD - Laboratorio de Bioquimica y Genetica Molecular, Facultad de Quimica, Universidad Autonoma de Yucatan, Merida, Yucatan, Mexico. FAU - Arana-Argaez, Victor AU - Arana-Argaez V AD - Laboratorio de Farmacologia, Facultad de Quimica, Universidad Autonoma de Yucatan, Merida, Yucatan, Mexico. FAU - Ramirez-Camacho, Mario AU - Ramirez-Camacho M AD - Centro de Informacion de Medicamentos y Farmacia Clinica, Facultad de Quimica, Universidad Autonoma de Yucatan, Merida, Yucatan, Mexico. FAU - Icaza-Chavez, Maria Eugenia AU - Icaza-Chavez ME AD - Clinica de Especialidades Gastrointestinales y Hepaticas, Christus Muguerza Hospital Faro del Mayab SA de CV, Merida, Yucatan, Mexico. LA - eng LA - spa PT - Journal Article TT - Indice metabolico como marcador predictivo no invasivo de esteatosis hepatica en pacientes con enfermedad del higado graso no alcoholico. DEP - 20260107 PL - Spain TA - Med Clin (Barc) JT - Medicina clinica JID - 0376377 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) RN - 0 (Triglycerides) SB - IM MH - Humans MH - Female MH - Male MH - *Non-alcoholic Fatty Liver Disease/diagnosis/metabolism/blood MH - Middle Aged MH - Adult MH - Retrospective Studies MH - Biomarkers/blood MH - Predictive Value of Tests MH - *Insulin Resistance MH - Sensitivity and Specificity MH - Aged MH - Young Adult MH - Aged, 80 and over MH - Adolescent MH - Blood Glucose/analysis MH - *Fatty Liver/diagnosis MH - Triglycerides/blood MH - Elasticity Imaging Techniques OTO - NOTNLM OT - Enfermedad de higado graso no alcoholico OT - Esteatosis OT - Insulin resistance OT - Marcador no invasivo OT - Metabolic index OT - Non-alcoholic fatty liver disease OT - Non-invasive marker OT - Resistencia a la insulina OT - Steatosis OT - Indice metabolico EDAT- 2026/01/09 00:26 MHDA- 2026/02/07 00:30 CRDT- 2026/01/08 18:04 PHST- 2025/04/14 00:00 [received] PHST- 2025/08/28 00:00 [revised] PHST- 2025/08/31 00:00 [accepted] PHST- 2026/02/07 00:30 [medline] PHST- 2026/01/09 00:26 [pubmed] PHST- 2026/01/08 18:04 [entrez] AID - S0025-7753(25)00496-8 [pii] AID - 10.1016/j.medcli.2025.107268 [doi] PST - ppublish SO - Med Clin (Barc). 2026 Jan;166(1):107268. doi: 10.1016/j.medcli.2025.107268. Epub 2026 Jan 7. PMID- 41505748 OWN - NLM STAT- MEDLINE DCOM- 20260108 LR - 20260826 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Jan 8 TI - The Effect of Digital Therapy-Based Aerobic Exercise on Children With Neuroblastoma: Protocol for a Prospective Controlled Trial. PG - e72698 LID - 10.2196/72698 [doi] LID - e72698 AB - BACKGROUND: Neuroblastoma, one of the most common extracranial solid tumors in children, often results in significant functional impairments, including muscle atrophy, reduced motor function, and sensory disturbances. While aerobic exercise has been shown to support functional recovery in patients with cancer, digital therapy-based aerobic exercise interventions have not yet been explored in pediatric neuroblastoma. OBJECTIVE: This study aims to develop and evaluate a digital intervention therapy to provide a safe, feasible, and tolerable home-based physical activity initiation protocol for children with neuroblastoma after chemoradiotherapy, with the main objectives of (1) breaking sedentary behavior habits and increasing daily energy expenditure, (2) gradually improving physical function (flexibility, basic muscle strength and muscle endurance, and balance ability), (3) establishing the habit of regular exercise and improving exercise self-efficacy, and (4) laying the foundation for a possible transition to more standard, albeit low-risk, aerobic exercise. METHODS: A total of 68 participants will be recruited and allocated to 2 groups matched in age and gender, with consideration given to the preferences of participants and their guardians. The control group will receive standard in-hospital medical treatment and health education, whereas the experimental group will receive a 6-month digital therapy-based aerobic exercise intervention in addition to standard care. Outcomes will be assessed at baseline and 3 and 6 months, with data collected for analysis. The primary outcomes are the 6-minute walk distance and the timed scores (in seconds) for the timed up and go and stair climb tests. The secondary outcomes include body composition, grip strength, and quality of life measured using the Pediatric Quality of Life Inventory version 4.0. RESULTS: Recruitment will be conducted from December 2025 to September 2026. We expect that the intervention group will show significantly greater improvements in physical function, physical activity levels, and fatigue management than the control group, demonstrating the effectiveness of digital therapy for rehabilitation training after radiotherapy and chemotherapy for neuroblastoma in children. CONCLUSIONS: We expect that the results of this study will provide evidence for rehabilitation after chemoradiotherapy in pediatric patients with neuroblastoma to improve physical function, physical activity levels, and fatigue management. In the future, expanding to multiple centers to conduct targeted surveys of different types of childhood cancers will help validate the effectiveness of digital therapy. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/72698. CI - (c)Xuan Zhou, Shihao Huang, Lixia Wang, Haibin Guo, Sisi Chen, Tingrui Li, Qing Du. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 08.01.2026. FAU - Zhou, Xuan AU - Zhou X AUID- ORCID: 0000-0002-1568-6039 AD - Department of Rehabilitation Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China. FAU - Huang, Shihao AU - Huang S AUID- ORCID: 0000-0002-4044-3514 AD - Department of Pediatric Hematologic Oncology, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China. FAU - Wang, Lixia AU - Wang L AUID- ORCID: 0009-0009-9422-0146 AD - Department of Rehabilitation Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China. FAU - Guo, Haibin AU - Guo H AUID- ORCID: 0000-0003-0058-4555 AD - Department of Rehabilitation Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China. FAU - Chen, Sisi AU - Chen S AUID- ORCID: 0009-0008-0787-3417 AD - Department of Rehabilitation Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China. FAU - Li, Tingrui AU - Li T AUID- ORCID: 0009-0002-6363-0731 AD - Department of Rehabilitation Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China. FAU - Du, Qing AU - Du Q AUID- ORCID: 0000-0002-4349-5088 AD - Department of Rehabilitation Medicine, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, Shanghai, China. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20260108 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Child MH - *Neuroblastoma/therapy/rehabilitation/physiopathology MH - *Exercise/physiology MH - *Exercise Therapy/methods MH - Prospective Studies MH - Male MH - Female MH - Quality of Life MH - Child, Preschool MH - Adolescent PMC - PMC12828307 OTO - NOTNLM OT - aerobic exercise OT - digital therapy OT - neuroblastoma OT - pediatrics OT - rehabilitation COIS- Conflicts of Interest: None declared. EDAT- 2026/01/08 19:23 MHDA- 2026/01/08 19:24 PMCR- 2026/01/08 CRDT- 2026/01/08 16:54 PHST- 2025/02/15 00:00 [received] PHST- 2025/11/10 00:00 [accepted] PHST- 2026/01/08 19:24 [medline] PHST- 2026/01/08 19:23 [pubmed] PHST- 2026/01/08 16:54 [entrez] PHST- 2026/01/08 00:00 [pmc-release] AID - v15i1e72698 [pii] AID - 10.2196/72698 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Jan 8;15:e72698. doi: 10.2196/72698. PMID- 41505421 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 1 DP - 2026 TI - Optimising gravimetric method interpretation using population-specific blood densities among Indonesian pregnant women: A cross-sectional study. PG - e0339391 LID - 10.1371/journal.pone.0339391 [doi] LID - e0339391 AB - BACKGROUND: The diagnosis of postpartum haemorrhage (PPH) depends heavily on accurate and timely blood loss assessment, yet no gold standard assessment method is available. Gravimetric methods are recommended for low-resource settings, but they require an accurate blood density value for interpretation. Currently, there are no data on the blood density of pregnant or labour women. OBJECTIVE: This study measured the blood density of Indonesian pregnant women to improve the reliability of the gravimetric results in estimating postpartum blood loss. METHODS: This cross-sectional study was conducted at a Private Midwifery Service Clinic in Bogor, Indonesia, involving 44 pregnant women who were at 37 weeks of gestation or later. During antenatal visits, 5 ml venous blood samples were collected, with women experiencing high-risk pregnancies being excluded. Descriptive statistics summarised the characteristics of the participants. Spearman's rank-order correlation was used to assess associations between study variables, and the Kruskal-Wallis test evaluated group differences. RESULTS: The mean blood density was 1.060 +/- 0.080 g/ml (range: 0.860-1.194 g/ml), with stable indoor and outdoor temperatures of 27 degrees C (SD = 1.13 degrees C and 1.22 degrees C, respectively). No significant correlations were found between blood density and maternal age, pre-pregnancy BMI, or gestational weight gain (p > 0.05). Kruskal-Wallis tests also revealed no significant differences across these variables (p > 0.05). CONCLUSION: Blood density among Indonesian pregnant women corresponds with established human reference values, supporting the use of population-specific blood density values to improve gravimetric blood loss estimation accuracy, thus facilitating early detection and prompt intervention of PPH. The observed variability suggests that factors other than demographics, maternal anthropometry, and the environment may affect blood density, necessitating further investigation in larger multisite studies. This study was reported in accordance with the STROBE checklist; the completed checklist is available as Supporting Information (S1 File). This study employed a cross-sectional design to measure blood densities of pregnant women at a single point in time. Participants were recruited during antenatal visits at Dyan's Private Midwifery-Service Clinic, Gunung Putri, Bogor, West Java, Indonesia. The health facility is a primary-level facility led by midwives and serves as the community's first point of contact for maternal and child health services. The health facility offers routine maternal health services, including antenatal care, childbirth assistance, postpartum follow-up, and family planning. As a primary-level facility, this health facility only provided care for women with low-risk pregnancies following the midwife's authority, while women with high-risk pregnancies or obstetrical/pathological conditions were referred to referral or obstetrician-led care facilities. The facility, situated in Gunung Putri, an industrial area adjacent to the capital city (Jakarta), serves a stable yet demographically diverse population drawn from various provinces and socioeconomic backgrounds, offering heterogeneous and broadly representative of Indonesia's diverse demographics. Although not fully representative of rural or coastal populations, the site offers a scientifically appropriate environment for studying blood density among pregnant Indonesian women. Prior to the commencement of the study, the participating facility provided permission for data collection. Data collection began on 8th January 2025 and ended on 21st April 2025. This study included pregnant women 37 weeks pregnant or older (based on the first day of the last menstrual cycle). To measure blood density, 5 ml venous blood samples were collected from all eligible participants. Pregnant women at high risk of pregnancy complications were not eligible to participate in the study. To ensure appropriate representation of the target population in this study, the sample size was determined using the Slovin formula by considering the total number of antenatal visits at Dyan's Private Midwifery Service Clinic between November 2023 and October 2024, which was 2,576. With an error tolerance of 0.15, a sample of 44 pregnant women was deemed sufficient to balance statistical precision with study feasibility. Given the exploratory, cross-sectional nature of the work, which focused on estimating blood density rather than group comparisons or hypothesis testing, this margin of error provided an acceptable level of precision. Accordingly, a sample size of 44 was adequate to support the optimisation of the gravimetric method for estimating postpartum blood loss. A consecutive sampling method was used to recruit participants. All pregnant women at the study site who met the predefined inclusion criteria were invited to participate in the study. Recruitment continued until the target sample size was achieved. As a preliminary cross-sectional study to estimate blood density and not population-level prevalence, consecutive sampling was considered suitable. All eligible participants were enrolled during the study period to minimise selection bias. CI - Copyright: (c) 2026 Mudarris et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Mudarris, Nelil AU - Mudarris N AD - Department of Midwifery, Universitas Bima Sakapenta, Bogor, Indonesia. FAU - Indrayani, Indrayani AU - Indrayani I AUID- ORCID: 0000-0002-4312-9061 AD - School of Human and Health Sciences, University of Huddersfield, Huddersfield, United Kingdom. AD - Department of Midwifery, Akademi Kebidanan Bina Husada Tangerang, Banten, Indonesia. FAU - Sudjarwo, Wisnu Arfian A AU - Sudjarwo WAA AD - Institute of Biophysics, Department of Natural Science and Sustainable Resources, BOKU University, Vienna, Austria. FAU - Anggraini, Dewi AU - Anggraini D AD - Department of Statistics, Faculty of Mathematics and Natural Sciences, Universitas Lambung Mangkurat, South Kalimantan, Indonesia. FAU - Oktaviany, Dyan AU - Oktaviany D AD - Department of Midwifery, Politeknik Bakti Asih Purwakarta, West Java, Indonesia. FAU - Singh, Devendra Raj AU - Singh DR AD - School of Human and Health Sciences, University of Huddersfield, Huddersfield, United Kingdom. FAU - Nugraheni, Galuh AU - Nugraheni G AD - Department of Midwifery, Universitas Bima Sakapenta, Bogor, Indonesia. FAU - Syafa'ah, Aminah AU - Syafa'ah A AD - Department of Midwifery, Universitas Bima Sakapenta, Bogor, Indonesia. LA - eng PT - Journal Article DEP - 20260108 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Cross-Sectional Studies MH - Indonesia MH - Adult MH - *Postpartum Hemorrhage/diagnosis/blood MH - Young Adult PMC - PMC12782393 COIS- The authors have declared that no competing interests exist. EDAT- 2026/01/08 19:23 MHDA- 2026/01/08 19:24 PMCR- 2026/01/08 CRDT- 2026/01/08 13:33 PHST- 2025/08/13 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/01/08 19:24 [medline] PHST- 2026/01/08 19:23 [pubmed] PHST- 2026/01/08 13:33 [entrez] PHST- 2026/01/08 00:00 [pmc-release] AID - PONE-D-25-43136 [pii] AID - 10.1371/journal.pone.0339391 [doi] PST - epublish SO - PLoS One. 2026 Jan 8;21(1):e0339391. doi: 10.1371/journal.pone.0339391. eCollection 2026. PMID- 41503735 OWN - NLM STAT- MEDLINE DCOM- 20260108 LR - 20260920 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 1 DP - 2026 Mar TI - Feasibility of a Psychoeducational Intervention for Empowering Parents to Optimise Feeding Practices in China: A Randomised Controlled Feasibility Trial. PG - e70155 LID - 10.1111/mcn.70155 [doi] LID - e70155 AB - Parental feeding practices play a crucial role in preventing childhood obesity and promoting healthy eating habits. However, few interventions are specifically designed to improve these practices. We aimed to assess the feasibility and preliminary effects of a novel psychoeducational intervention, Empower Parents to Optimise Feeding Practices (EPO-Feeding), tailored to enhance parental feeding practices in China. A parallel-arm feasibility randomised controlled trial (RCT) was conducted in two public kindergartens in Yangzhou, China. Participants were randomly assigned to the intervention group (EPO-Feeding programme plus usual care) or control group (usual care). Data were collected at baseline, post-intervention, and 1 month after intervention. Descriptive statistics assessed feasibility and acceptability, while analysis of variance for repeated measures and generalised estimating equations analysed continuous and categorical outcomes across time points, respectively. Within 2 weeks, 131 parents expressed interest, and 84 eligible participants were randomly assigned. Module attendance and retention rates were high, with 83.3% (n = 35) completing all sessions and 97.6% (n = 82) completing all measurements. Satisfaction surveys indicated high acceptability. Statistically significant improvements were observed in the intervention group, including increased encouragement of healthy eating and monitoring, reduced pressure to eat and food as rewards, improved weight accurate perception, and enhanced parenting efficacy (p < 0.05). However, no significant effects were found in long-term outcomes, including children's eating behaviours and weight status. This study demonstrates high feasibility and acceptability of the EPO-Feeding programme and suggests its potential to support Chinese parents' feeding strategies. A full-scale RCT is recommended. Trial registration. It was registered with ClinicalTrials.gov (NCT06181773), 20/11/2023. CI - (c) 2025 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Wang, Jian AU - Wang J AUID- ORCID: 0000-0002-4905-2990 AD - Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, London, UK. FAU - Chang, Yan-Shing AU - Chang YS AUID- ORCID: 0000-0002-9086-4472 AD - Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, London, UK. FAU - Wei, Xiaoxue AU - Wei X AD - Department of Haematology and Oncology, Shanghai Children's Medical Centre Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Cao, Yang AU - Cao Y AUID- ORCID: 0000-0002-3552-9153 AD - Clinical Epidemiology and Biostatistics, School of Medical Sciences, Faculty of Medicine and Health, Orebro University, Orebro, Sweden. AD - Unit of Integrative Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. FAU - Winkley, Kirsty AU - Winkley K AUID- ORCID: 0000-0002-1725-6040 AD - Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, London, UK. LA - eng SI - ClinicalTrials.gov/NCT06181773 PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - China MH - Female MH - Feasibility Studies MH - Male MH - *Parents/psychology/education MH - *Feeding Behavior/psychology MH - Adult MH - Pediatric Obesity/prevention & control MH - Child, Preschool MH - *Diet, Healthy/psychology MH - *Parenting/psychology MH - *Empowerment PMC - PMC12780882 OTO - NOTNLM OT - feeding practices OT - parents OT - preschool children OT - psychoeducational intervention OT - weight perception COIS- The authors declare no conflicts of interest. EDAT- 2026/01/08 07:13 MHDA- 2026/01/08 07:14 PMCR- 2026/01/08 CRDT- 2026/01/08 05:13 PHST- 2025/10/18 00:00 [revised] PHST- 2025/05/07 00:00 [received] PHST- 2025/12/02 00:00 [accepted] PHST- 2026/01/08 07:14 [medline] PHST- 2026/01/08 07:13 [pubmed] PHST- 2026/01/08 05:13 [entrez] PHST- 2026/01/08 00:00 [pmc-release] AID - MCN70155 [pii] AID - 10.1111/mcn.70155 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Mar;22(1):e70155. doi: 10.1111/mcn.70155. PMID- 41503664 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 1460-9592 (Electronic) IS - 1155-5645 (Linking) VI - 36 IP - 4 DP - 2026 Apr TI - Reliability of the Pediatric-Specific American Society of Anesthesiologists Physical Status (ASA-PS) Classification System. PG - 396-400 LID - 10.1002/pan.70112 [doi] AB - BACKGROUND: The American Society of Anesthesiologists Physical Status (ASA-PS) classification system is widely used to classify patient comorbidities prior to surgery and is often used as a marker of perioperative risk. Since its inception in 1941, it has undergone modifications to adapt to changing clinical needs and to improve its reliability. In 2020, a version of the ASA-PS was released with pediatric-specific case examples. AIM: To explore inter-rater reliability in ASA-PS scoring in the pediatric population. METHODS: This single-center retrospective study evaluated the assigned ASA-PS scores of 364 patients at a quaternary pediatric hospital. Each patient was assigned three ASA-PS scores-one by the case anesthetist and one each by two independent consultant anesthetists using the ASA guidance issued in 2020. Concordance was measured between the assigned scores, and potential reasons for discordant scores were identified. RESULTS: There was strong concordance of ASA-PS scores between the two independently scoring anesthetists (weighted kappa coefficient 0.76), but only moderate concordance between the case anesthetist and the independent anesthetists (weighted kappa coefficient 0.5). Where there was a discrepancy, the case anesthetist had usually underscored the ASA-PS by 1 point. Patients who had symptomatic cardiac disease, abnormal body mass index for age, an oncologic state, brain malformation, or a difficult airway were more likely to be assigned an incorrect ASA-PS score. CONCLUSIONS: Moderate inter-rater variability exists in the assignment of ASA-PS scores in the pediatric population, and many patients are being underscored. Use of ASA guidance to assist with pediatric ASA-PS scoring improves the reliability of scoring and may improve accurate communication of perioperative risk. CI - (c) 2026 John Wiley & Sons Ltd. FAU - Liu, Lucy AU - Liu L AUID- ORCID: 0000-0003-1170-3919 AD - Department of Anaesthesia, Great Ormond Street Hospital for Children, London, UK. AD - Department of Anaesthesia, University College Hospital, London, UK. FAU - Foote, Lucy AU - Foote L AD - Department of Anaesthesia, Great Ormond Street Hospital for Children, London, UK. FAU - Kolyvaki, Evgenia AU - Kolyvaki E AD - Department of Anaesthesia, Charing Cross Hospital, London, UK. FAU - Lyons, Craig AU - Lyons C AD - Department of Anaesthesia, Great Ormond Street Hospital for Children, London, UK. AD - Department of Anaesthesia, Galway University Hospitals, Galway, Ireland. FAU - Laycock, Helen AU - Laycock H AD - Department of Anaesthesia, Great Ormond Street Hospital for Children, London, UK. LA - eng PT - Journal Article DEP - 20260108 PL - France TA - Paediatr Anaesth JT - Paediatric anaesthesia JID - 9206575 SB - IM MH - Humans MH - Child MH - Reproducibility of Results MH - Female MH - Retrospective Studies MH - Child, Preschool MH - Infant MH - Male MH - Pediatric Anesthesia MH - Adolescent MH - Anesthesiologists MH - United States MH - Societies, Medical MH - *Health Status MH - Infant, Newborn EDAT- 2026/01/08 07:13 MHDA- 2026/03/10 07:00 CRDT- 2026/01/08 04:50 PHST- 2025/12/04 00:00 [revised] PHST- 2025/05/06 00:00 [received] PHST- 2025/12/16 00:00 [accepted] PHST- 2026/03/10 07:00 [medline] PHST- 2026/01/08 07:13 [pubmed] PHST- 2026/01/08 04:50 [entrez] AID - 10.1002/pan.70112 [doi] PST - ppublish SO - Paediatr Anaesth. 2026 Apr;36(4):396-400. doi: 10.1002/pan.70112. Epub 2026 Jan 8. PMID- 41503121 OWN - NLM STAT- MEDLINE DCOM- 20260108 LR - 20260926 IS - 2046-1402 (Electronic) IS - 2046-1402 (Linking) VI - 14 DP - 2025 TI - Validation of the Thai version of the World Health Organization's Quality of Life Scale (WHOQOL-BREF-THAI) among Thai nursing students in northeast Thailand: A multi-centre study. PG - 241 LID - 10.12688/f1000research.161251.3 [doi] LID - 241 AB - BACKGROUND: The Thai version of the World Health Organization Quality of Life Scale (WHOQOL-BREF-THAI) has been verified among a variety of populations. However, there is a lack of existing research on its comprehensive psychometric properties, specifically when used with nursing students. This study aimed to assess the psychometric properties (construct validity, internal consistency, and convergent validity) of the WHOQOL-BREF- THAI among nursing students in northeastern Thailand. METHODS: In this methodology study, Thai nursing students were recruited using multi-stage simple random sampling from universities located in the northeast of Thailand. The data was collected via self-assessment questionnaires, and the 3,570 participants were then randomly split into two subsamples. After reducing the number of items using statistical methods, construct validity was identified by performing exploratory factor analysis (EFA) (n = 2,000), confirmatory factor analysis (CFA) (n = 1,570), and convergent validity using average variance extracted (AVE). For scale reliability, the internal consistency and stability were performed using Cronbach's Alpha Coefficient and composite reliability (CR). RESULTS: Principal component analysis on a random subsample supported a four-factor model with 24 items, originally suggested for factorial construct validity; these 24 items were distributed across the original four domain with a cumulative variance of 75.6%. CFA of the model revealed satisfactory indices of fitness (Chi-square/degree of freedom (CMIN/DF) = 113; root mean square error of approximation = 0.05; goodness of fit index = 0.97; and Tucker-Levis index = 0.91). The internal consistency was highly satisfactory (Cronbach's alpha was greater than 0.70) for both the total scale and ksubscales, and the CR values of the four domains, ranging from 0.76 to 0.95, indicated evidence of acceptable reliability. In terms of convergent validity, AVE revealed that all WHOQOL-BREF-THAI subscales achieved convergence, with AVE values ranging from 0.50 to 0.69. CONCLUSION: These results reveal that the WHOQOL-BREF-THAI is a valid and reliable tool which health care providers can utilize to measure QOL among Thai nursing students. Therefore, the WHOQOL-BREF can serve as an essential tool for researching the factors influencing nursing students' QOL, with implications for nursing education. CI - Copyright: (c) 2025 Summart U et al. FAU - Summart, Ueamporn AU - Summart U AUID- ORCID: 0000-0001-9557-2199 AD - Faculty of Nursing, Roi Et Rajabhat University, Kho Kaew Subdistrict, Selaphum District, Roi Et, 45120, Thailand. FAU - Sangruangake, Monthida AU - Sangruangake M AD - Faculty of Nursing, Udon Thani Rajabhat University, Udon Thani, Udon Thani, Thailand. FAU - Charoensaen, Jumrusluk AU - Charoensaen J AD - Faculty of Nursing, Roi Et Rajabhat University, Ko Kaeo Subdistrict, Selaphum District, Roi Et, Thailand. FAU - Suebsoontorn, Wiraporn AU - Suebsoontorn W AD - Faculty of Nursing, Nakhon Ratchasima Rajabhat University, Nakhon Ratchasima, Nakhon Ratchasima, Thailand. FAU - Songthamwat, Metha AU - Songthamwat M AUID- ORCID: 0000-0002-5694-8138 AD - Department of Obstetric and Gynaecology, Udon Thani Hospital, Udon Thani, Udon Thani, Thailand. LA - eng SI - figshare/10.6084/m9.figshare.28136420.v2 PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20250722 PL - England TA - F1000Res JT - F1000Research JID - 101594320 SB - IM MH - Humans MH - Thailand MH - *Students, Nursing MH - *Quality of Life MH - Female MH - Male MH - *World Health Organization MH - *Psychometrics MH - Surveys and Questionnaires MH - Young Adult MH - Reproducibility of Results MH - Adult MH - Adolescent MH - Factor Analysis, Statistical MH - Southeast Asian People PMC - PMC12770885 OTO - NOTNLM OT - Confirmatory factor analysis. OT - Nursing OT - Quality of life OT - Southeast Asian people OT - WHOQOL-BREF COIS- No competing interests were disclosed. EDAT- 2026/01/08 07:13 MHDA- 2026/01/08 07:14 PMCR- 2025/07/22 CRDT- 2026/01/08 04:43 PHST- 2025/07/21 00:00 [accepted] PHST- 2026/01/08 07:14 [medline] PHST- 2026/01/08 07:13 [pubmed] PHST- 2026/01/08 04:43 [entrez] PHST- 2025/07/22 00:00 [pmc-release] AID - 10.12688/f1000research.161251.3 [doi] PST - epublish SO - F1000Res. 2025 Jul 22;14:241. doi: 10.12688/f1000research.161251.3. eCollection 2025. PMID- 41502821 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260522 LR - 20260919 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Establishing percentiles for phase angle, skeletal muscle mass index, and muscle-to-fat ratio in Brazilian adolescents: a bioelectrical impedance analysis study with 59,000 participants. PG - 1686037 LID - 10.3389/fnut.2025.1686037 [doi] LID - 1686037 AB - BACKGROUND: Reliable normative references for adolescent body composition are essential for screening and surveillance, yet Brazilian data at national scale remain scarce and heterogeneous across methods and devices. OBJECTIVES: To generate age- and sex-specific reference curves for phase angle (PhA), skeletal muscle mass index (SMMI), and muscle-to-fat ratio (MFR) in Brazilian adolescents, and to present device- dependent body fat percentage (%BF) percentiles as secondary, interpretation- cautioned outputs. METHODS: We analyzed a frozen, de-identified extract of routine multi- frequency bioimpedance assessments (10.00-19.99 years) spanning all five Brazilian macro-regions and multiple recruitment contexts (schools, clinics/primary care, private practices, gyms/fitness centers, community programs). The extract is produced by a vendor privacy/QA pipeline compliant with LGPD; upstream cleaning logs are not accessible to the authors. Prespecified plausibility and deduplication rules (anthropometry and impedance thresholds; robust BIVA on R/H and Xc/H) were re- applied and yielded no additional exclusions. Sex-specific age curves were modeled with GAMLSS (LMS) to estimate smoothed percentiles (P3, P10, P25, P50, P75, P90, P97). %BF, derived from a proprietary embedded equation, is reported as secondary. RESULTS: The analytic cohort comprised 59,000 adolescents from all macro-regions and diverse contexts. Median PhA, SMMI, and MFR increased with age in boys and showed the expected attenuated or plateauing patterns in girls across mid- to late adolescence. Percentile spreads widened with age for muscle-related indices, indicating growing interindividual variability. Device-dependent %BF percentiles exhibited age- and sex- specific trajectories consistent with physiological expectations but should be interpreted with caution pending external validation. CONCLUSIONS: We provide national reference percentiles for PhA, SMMI, and MFR that are immediately useful for clinical and public- health applications and less sensitive to device-specific assumptions. %BF curves are offered as secondary and require independent validation against a criterion method before routine use. Future work should confirm regional representativeness and cross-device portability. CI - Copyright (c) 2025 Teixeira, Motta, Sa Filho, Oliveira Silva, Leonardo and Lopes-Martins. FAU - Teixeira, Fernando Guimaraes AU - Teixeira FG AD - Programa de Pos-Graduacao em Ciencias do Movimento Humano e Reabilitacao, Universidade Evangelica de Goias-UniEvangelica, Anapolis, Brazil. FAU - Motta, Flavio Andrade Amaral AU - Motta FAA AD - Hospital do Cancer de Muriae-Fundacao Cristiano Varella, Muriae, Brazil. FAU - de Sa Filho, Alberto Souza AU - de Sa Filho AS AD - Programa de Pos-Graduacao em Ciencias do Movimento Humano e Reabilitacao, Universidade Evangelica de Goias-UniEvangelica, Anapolis, Brazil. FAU - de Oliveira Silva, Iranse AU - de Oliveira Silva I AD - Programa de Pos-Graduacao em Ciencias do Movimento Humano e Reabilitacao, Universidade Evangelica de Goias-UniEvangelica, Anapolis, Brazil. FAU - Leonardo, Patricia Sardinha AU - Leonardo PS AD - Faculdade de Medicina, Afya Centro Universitario Itaperuna, Itaperuna, Brazil. FAU - Lopes-Martins, Rodrigo Alvaro Brandao AU - Lopes-Martins RAB AD - Hospital do Cancer de Muriae-Fundacao Cristiano Varella, Muriae, Brazil. AD - Faculdade de Medicina, Afya Centro Universitario Itaperuna, Itaperuna, Brazil. AD - Programa de Pos-Graduacao em Bioengenharia, Universidade Brasil, Sao Paulo, Brazil. LA - eng PT - Journal Article DEP - 20251223 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 EIN - Front Nutr. 2026 May 05;13:1863696. doi: 10.3389/fnut.2026.1863696. PMID: 42163958 PMC - PMC12771542 OTO - NOTNLM OT - BIA OT - adolescents OT - bioelectrical impedance analysis OT - body composition OT - phase angle OT - reference values COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/08 07:13 MHDA- 2026/01/08 07:14 PMCR- 2025/12/23 CRDT- 2026/01/08 04:38 PHST- 2025/08/14 00:00 [received] PHST- 2025/11/14 00:00 [revised] PHST- 2025/11/17 00:00 [accepted] PHST- 2026/01/08 07:13 [pubmed] PHST- 2026/01/08 07:14 [medline] PHST- 2026/01/08 04:38 [entrez] PHST- 2025/12/23 00:00 [pmc-release] AID - 10.3389/fnut.2025.1686037 [doi] PST - epublish SO - Front Nutr. 2025 Dec 23;12:1686037. doi: 10.3389/fnut.2025.1686037. eCollection 2025. PMID- 41502054 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) VI - 82 IP - 3 DP - 2026 Mar TI - The impact of patient perspective on the pediatric endoscopy as part of the Italian EndoPed Quality Improvement Initiative. PG - 848-857 LID - 10.1002/jpn3.70314 [doi] AB - OBJECTIVE: Patient satisfaction (PS) is an important healthcare outcome and should be an integral part of quality improvement agendas. Between 2019 and 2021, the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition, Endoscopy Interest Group conducted a nationwide quality assessment survey, EndoPed. One of the study's aims was to identify areas for improvement based on the results of a PS questionnaire. METHODS: The smartphone app-based, prospective survey involved 24 Italian pediatric endoscopy centers. Procedure details and quality standards were recorded. The modified Group Health Association of America-9 (GHAA-9m) satisfaction questionnaire consisted of 7 Likert-scale questions that explored waiting times, communication, and staff evaluation. Two additional closed questions investigated the will to confirm the endoscopist and the facility. Dissatisfaction was defined with the arbitrary cut-off of < 7/10. RESULTS: Questionnaire results were available for 1974 (55%) procedures. The questionnaire's internal consistency was good (Cronbach's alpha 0.86). Overall satisfaction was high. Shorter operator experience (odds ratio [OR] 4 [95% confidence interval [CI] 1.6 to -10.3]; p < 0.003), prolonged waiting time (OR 2.7 [95%CI 1.6-4.5]; p < 0.000), prolonged procedure duration (OR 2.9 [95% CI 1.8-4.7]; p < 0.000) and conscious sedation (OR 5 [95% CI 3-6.2]; p < 0.000) were confirmed in a multivariate model to be associated to lower satisfaction rates. CONCLUSIONS: Through a standardized methodology, the PS questionnaire is a valuable tool for clinical quality assessment. PS highlight improvement fields different from those identified by quality standards and items, adding elements for an exhaustive quality evaluation. Interventions derived from PS analysis could help to improve pediatric endoscopy. CI - (c) 2026 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Morotti, Francesco AU - Morotti F AUID- ORCID: 0000-0002-0602-0155 AD - Neonatology and Neonatal Intensive Care Unit, Spedali Civili Children's Hospital, Brescia, Italy. FAU - Russo, Giusy AU - Russo G AD - Department of Maternal and Child Health, Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome, Italy. FAU - Ruggiero, Cosimo AU - Ruggiero C AD - Department of Maternal and Child Health, Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome, Italy. FAU - Fava, Giorgio AU - Fava G AD - Department of Pediatric Surgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. FAU - Ichino, Martina AU - Ichino M AD - Department of Pediatric Surgery, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. FAU - Di Nardo, Giovanni AU - Di Nardo G AD - Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy. FAU - Furio, Silvia AU - Furio S AD - Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy. FAU - Piccirillo, Marisa AU - Piccirillo M AD - Department of Neurosciences, Mental Health and Sensory Organs (NESMOS), Sapienza University of Rome, Pediatric Unit, Sant'Andrea University Hospital, Rome, Italy. FAU - Pellegrino, Maristella AU - Pellegrino M AD - Department of Pediatric Surgery, ASST GOM Niguarda, Milan, Italy. FAU - Macchini, Francesco AU - Macchini F AD - Department of Pediatric Surgery, ASST GOM Niguarda, Milan, Italy. FAU - Deganello Saccomani, Marco AU - Deganello Saccomani M AD - Department of Pediatrics, Woman's & Child's University Hospital of Verona, Verona, Italy. FAU - Banzato, Claudia AU - Banzato C AD - Department of Pediatrics, Woman's & Child's University Hospital of Verona, Verona, Italy. FAU - Nicastro, Emanuele AU - Nicastro E AD - Pediatric Hepatology Gastroenterology and Transplantation Unit, ASST Papa Giovanni XXIII, Bergamo, Italy. FAU - Orizio, Paolo AU - Orizio P AD - Department of Pediatric Surgery, Spedali Civili Children's Hospital, Brescia, Italy. FAU - Pizzol, Antonio AU - Pizzol A AD - Pediatric Gastroenterology Unit, Regina Margherita Children's Hospital, Azienda Ospedaliera-Universitaria Citta della Salute e della Scienza di Torino, Turin, Italy. FAU - Chiaro, Andrea AU - Chiaro A AD - Pediatric Gastroenterology and Endoscopy Unit, IRCCS Istituto Giannina Gaslini, Genova, Italy. FAU - Strisciuglio, Caterina AU - Strisciuglio C AD - Department of Woman, Child and General and Specialized Surgery, University of Campania "Luigi Vanvitelli", Naples, Italy. FAU - Fornaroli, Fabiola AU - Fornaroli F AD - Department of Medicine and Surgery, Gastroenterology and Endoscopy Unit, University of Parma, Parma, Italy. FAU - Mantegazza, Cecilia AU - Mantegazza C AD - Department of Pediatric Surgery, Vittore Buzzi Children's Hospital, Milan, Italy. FAU - Parma, Barbara AU - Parma B AD - Department of Pediatric, Mariani Foundation Center for Fragile Child, ASST-Lariana, Sant'Anna Hospital, San Fermo della Battaglia, Como, Italy. FAU - Bongiovanni, Annarita AU - Bongiovanni A AD - Department of Clinical and Experimental Medicine, Pediatric Respiratory Unit, San Marco Hospital, University of Catania. Catania, Italy. FAU - Pacenza, Caterina AU - Pacenza C AD - Department of Pediatrics, San Giovanni di Dio Hospital, Crotone, Italy. FAU - Faraci, Simona AU - Faraci S AD - Department of Pediatric Gastroenterology and Endoscopy, Ospedale Pediatrico Bambin Gesu, Roma, Italy. FAU - Oliva, Salvatore AU - Oliva S AD - Department of Maternal and Child Health, Pediatric Gastroenterology and Liver Unit, Sapienza University of Rome, Rome, Italy. FAU - Norsa, Lorenzo AU - Norsa L AD - Department of Pediatrics, Vittore Buzzi Children's Hospital, Milan, Italy. LA - eng GR - None/ PT - Journal Article DEP - 20260107 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM MH - Humans MH - *Patient Satisfaction/statistics & numerical data MH - Italy MH - *Quality Improvement MH - Surveys and Questionnaires MH - Prospective Studies MH - Child MH - Female MH - *Pediatrics/standards MH - Male MH - *Endoscopy, Gastrointestinal/standards OTO - NOTNLM OT - endoscopy services OT - patient questionnaire OT - patient satisfaction OT - pediatric gastroenterology EDAT- 2026/01/08 07:13 MHDA- 2026/03/07 18:38 CRDT- 2026/01/08 01:12 PHST- 2025/11/05 00:00 [revised] PHST- 2025/08/16 00:00 [received] PHST- 2025/11/27 00:00 [accepted] PHST- 2026/03/07 18:38 [medline] PHST- 2026/01/08 07:13 [pubmed] PHST- 2026/01/08 01:12 [entrez] AID - 10.1002/jpn3.70314 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Mar;82(3):848-857. doi: 10.1002/jpn3.70314. Epub 2026 Jan 7. PMID- 41501913 OWN - NLM STAT- MEDLINE DCOM- 20260206 LR - 20260702 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 27 IP - 1 DP - 2026 Jan 8 TI - Avoiding routine gastric residual volume measurement in neonatal critical care (the neoGASTRIC trial): study protocol for a multi-centre, unblinded, randomised, controlled trial. PG - 106 LID - 10.1186/s13063-025-09403-7 [doi] LID - 106 AB - BACKGROUND: Routine measurement of gastric residual volumes involves regularly aspirating the entire stomach contents to assess the volume and colour of the aspirate to inform feeding. This is an established practice in many United Kingdom and Australian neonatal units for preterm infants receiving gastric tube feeds. The rationale is to assess feed tolerance and to predict and potentially prevent necrotising enterocolitis, a serious gut condition. Routine measurement of gastric residual volumes may also be associated with adverse outcomes and harm, including delayed achievement of full enteral feeds and longer neonatal unit stay. Evidence to support the routine measurement of gastric residuals is poor, and previous small trials have not been generalisable to UK or Australian neonatal care. METHODS: The aim of the neoGASTRIC trial is to test whether avoiding routine measurement of gastric residual volumes in preterm infants reduces the time taken for an infant to reach full enteral feeds without increasing necrotising enterocolitis. neoGASTRIC is an individually randomised controlled trial in neonatal units in the UK and Australia. A target of 7040 infants born before 34 weeks' gestation will be randomly allocated, prior to receiving 24 h of enteral feeds > 15 ml/kg/day, on a 1:1 basis to have no routine gastric residual volumes measured, or to have gastric residual volumes measured routinely. Opt-out consent will be used with parent and staff views explored as part of an embedded process evaluation. The primary superiority outcome is time to reach full milk feeds >/= 145 ml/kg/day for three consecutive days. Bell's stage 2 or 3 necrotising enterocolitis following blinded adjudication will be the key secondary, non-inferiority safety outcome. Other neonatal core outcomes and health care resource use and costs prior to discharge will be evaluated. DISCUSSION: neoGASTRIC will address a research priority that affects more than 20,000 preterm infants in the United Kingdom and Australia annually. Even modest improvements in clinical outcomes and resource use could result in large clinical benefits and savings at a population level. TRIAL REGISTRATION: ISRCTN 16710849 . Prospectively registered on 8 February 2023. CI - (c) 2026. The Author(s). FAU - Nuthall, Elizabeth AU - Nuthall E AD - National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, UK. FAU - Rodriquez, Amy AU - Rodriquez A AD - Department of Paediatrics, Monash Newborn, Monash Children's Hospital, Monash University, Clayton, Australia. FAU - Andrzejewksa, Iza AU - Andrzejewksa I AD - Chelsea and Westminster Hospital, Neonatal Intensive Care Unit, London, UK. FAU - Aslam, Zainab AU - Aslam Z AD - National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, UK. FAU - Battersby, Cheryl AU - Battersby C AD - Neonatal Medicine, School of Public Health, Faculty of Medicine, Imperial College London, London, UK. FAU - Beesley, Catherine AU - Beesley C AD - Consumer Advisory Group, NHMRC CRE in Newborn Medicine, Murdoch Children's Research Institute, Parkville, Australia. FAU - Cole, Christina AU - Cole C AD - National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, UK. FAU - Campbell, Helen AU - Campbell H AD - National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, UK. FAU - Dalziel, Kim AU - Dalziel K AD - Health Economics Group, Melbourne School of Population and Global Health, University of Melbourne, Melbourne, Australia. FAU - Dorling, Jon AU - Dorling J AD - University of Leeds, Leeds, UK. FAU - Downs, Alan AU - Downs A AD - National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, UK. FAU - Davis, Peter G AU - Davis PG AD - The Royal Women's Hospital, University of Melbourne, Melbourne, Australia. FAU - Daskalopoulou, Zoe AU - Daskalopoulou Z AD - National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, UK. FAU - Forster, Amanda AU - Forster A AD - James Cook University Hospital, Middlesbrough, UK. FAU - Graham-Travis, Michaela AU - Graham-Travis M AD - National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, UK. FAU - Hall, Nigel J AU - Hall NJ AD - University Surgery Unit, Faculty of Medicine, University of Southampton, Southampton, UK. FAU - Hubbard, Marie AU - Hubbard M AD - University Hospitals of Leicester NHS Trust, Leicester, UK. FAU - Hurd, Madeleine AU - Hurd M AD - National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, UK. FAU - Hardy, Pollyanna AU - Hardy P AD - National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, UK. FAU - Hunt, Rod AU - Hunt R AD - Department of Paediatrics, Department of Neonatal Medicine, Monash University, Monash Health Cerebral Palsy Alliance, University of Sydney, Sydney, Australia. FAU - Kennedy, Ann AU - Kennedy A AD - National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, UK. FAU - King, Andrew AU - King A AD - National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, UK. FAU - Linsell, Louise AU - Linsell L AD - University of Oxford, Oxford, UK. FAU - Manley, Brett J AU - Manley BJ AD - Department of Obstetrics and Gynaecology, Mercy Perinatal, Mercy Hospital for Women, The University of Melbourne, Melbourne, Australia. FAU - Murray, David AU - Murray D AD - National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, UK. FAU - Mitchell, Tracy K AU - Mitchell TK AD - Department of Public Health Policy and Systems, University of Liverpool, Liverpool, UK. FAU - O'Connor, Heather AU - O'Connor H AD - National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, UK. FAU - Ojha, Shalini AU - Ojha S AD - University of Nottingham, Nottingham, UK. FAU - Roehr, Charles C AU - Roehr CC AD - National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, UK. AD - Faculty of Health and Life Sciences, University of Bristol, Bristol, UK. FAU - Rivero-Arias, Oliver AU - Rivero-Arias O AD - National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, UK. FAU - Stanbury, Kayleigh AU - Stanbury K AD - National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, UK. FAU - Taylor, Jacqueline AU - Taylor J AD - Department of Paediatrics, Monash Newborn, Monash Children's Hospital, Monash University, Clayton, Australia. FAU - Tume, Lyvonne AU - Tume L AD - Edge Hill University, Ormskirk, Alder Hey Children's NHS FT, Liverpool, UK. FAU - Welsh, Richard AU - Welsh R AD - National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, UK. FAU - Wiles, Joy AU - Wiles J AD - National Perinatal Epidemiology Unit Clinical Trials Unit, Nuffield Department of Population Health, University of Oxford, Old Road Campus, Oxford, UK. FAU - Woolfall, Kerry AU - Woolfall K AD - Department of Public Health Policy and Systems, University of Liverpool, Liverpool, UK. FAU - Young, Lauren AU - Young L AD - SSNAP (Support for Sick Newborn and Their Parents), Oxford, UK. FAU - Roberts, Calum AU - Roberts C AD - Department of Paediatrics, Monash Newborn, Monash Children's Hospital, Monash University, Clayton, Australia. AD - The Ritchie Centre, Hudson Institute of Medical Research, Clayton, Australia. FAU - Gale, Chris AU - Gale C AUID- ORCID: 0000-0003-0707-876X AD - Chelsea and Westminster Hospital, Neonatal Intensive Care Unit, London, UK. christopher.gale@imperial.ac.uk. AD - School of Public Health and Centre for Paediatrics and Child Health, Faculty of Medicine, Chelsea and Westminster Campus, Imperial College London, London, UK. christopher.gale@imperial.ac.uk. CN - neoGASTRIC collaborative group LA - eng GR - NIHR134216/Health Technology Assessment Programme/ GR - NHMRC2014792/National Health and Medical Research Council/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20260108 PL - England TA - Trials JT - Trials JID - 101263253 SB - IM MH - Humans MH - Infant, Newborn MH - *Enteral Nutrition/adverse effects/methods MH - *Enterocolitis, Necrotizing/prevention & control/etiology MH - Multicenter Studies as Topic MH - Randomized Controlled Trials as Topic MH - *Infant, Premature MH - Time Factors MH - Residual Volume MH - Gestational Age MH - United Kingdom MH - Australia MH - *Gastrointestinal Contents MH - Predictive Value of Tests MH - *Intensive Care, Neonatal/methods PMC - PMC12874682 OTO - NOTNLM OT - Enteral feeding OT - Feeding intolerance OT - Gastric residual volume OT - Gastric tube feeds OT - Infant OT - Necrotising enterocolitis (NEC) OT - Neonatal care OT - Neonatal nutrition OT - Preterm OT - Protocol OT - Randomised controlled trial COIS- Declarations. Ethics approval and consent to participate 30: The neoGASTRIC trial was approved by the London - Riverside Research Ethics Committee on 8 February 2023, Ref: 23/LO/0060, and the Monash Health Human Research Ethics Committee on 30 March 2023, Ref: RES-22-0000-724A. The neoGASTRIC trial will use an opt-out approach to consent. Parents or carers will be informed about neoGASTRIC through posters, a leaflet and/or electronic media given when their infant is admitted to the neonatal unit. Study information will be made available to parents/carers prior to randomisation. After this information is made available, infants meeting the eligibility criteria will automatically be included in the trial unless parents express a wish for them not to (to opt out of trial participation). Opt-out consent will cover data linkage to routinely recorded long-term outcome data (for UK trial participants this will be NNRD, Hospital Episode Statistics and the National Pupil Database) and for Australian trial participants this will be administrative hospital costing records from individual participating hospitals. Competing interests 7b: CG is chair of the NIHR Research for Patient Benefit Regional Assessment Panel, London; CG has received grant funding for research from the NIHR (including for neoGASTRIC), the MRC, Action Medical Research, Rosetrees Foundation and Chiesi Pharmaceuticals. CR has received grant funding for research from the NHMRC (including for neoGASTRIC), Heart Foundation of Australia, Cerebral Palsy Alliance (Australia), Royal Australasian College of Physicians, and Chiesi Pharmaceuticals. CB is supported by a Personal fellowship awarded by the UK National Institute for Health and Care Research (NIHR) All other authors have nothing to declare. FIR - Stokes, Caz IR - Stokes C FIR - Thwin, The' IR - Thwin T FIR - McKenna, Amanda IR - McKenna A FIR - Hughes, Sharon IR - Hughes S FIR - Lewis, Lucy IR - Lewis L FIR - Brooke, Nigel IR - Brooke N FIR - Farmer, Sarah IR - Farmer S FIR - Dalton, Laura IR - Dalton L FIR - Wane, Rachel IR - Wane R FIR - Baticula, Joan IR - Baticula J FIR - Simmons, Abigail IR - Simmons A FIR - Hollands, Heidi IR - Hollands H FIR - Stares, Jasmine IR - Stares J FIR - Brooke, Nigel IR - Brooke N FIR - Farmer, Sarah IR - Farmer S FIR - Lee, Geraint IR - Lee G FIR - Broomfield, Helen IR - Broomfield H FIR - Robinson, Joanna IR - Robinson J FIR - Senior, Sally IR - Senior S FIR - Jones, Jennifer IR - Jones J FIR - Rackham, Oliver IR - Rackham O FIR - Pickup, Matthew IR - Pickup M FIR - Johns, Catrin IR - Johns C FIR - Icke, Becky IR - Icke B FIR - Hoskin, Amy IR - Hoskin A FIR - Davies, Ruth IR - Davies R FIR - Benn, Tracey IR - Benn T FIR - Lek, Elizabeth IR - Lek E FIR - Fowler, Laura IR - Fowler L FIR - Lal, Komal IR - Lal K FIR - Ouseph, Jiji IR - Ouseph J FIR - Gauci, Philip Amato IR - Gauci PA FIR - Capell, Alys IR - Capell A FIR - Wilson, Helen IR - Wilson H FIR - Aladangady, Narendra IR - Aladangady N FIR - Fleming, Paul IR - Fleming P FIR - Stacey, Fiona IR - Stacey F FIR - Yates, Helen IR - Yates H FIR - Sherris, Leanne IR - Sherris L FIR - Williams, Tammana IR - Williams T FIR - Taylor, Elizabeth IR - Taylor E FIR - Vass, Geza IR - Vass G FIR - Adams, Eleri IR - Adams E FIR - Ward, Bryony IR - Ward B FIR - Newson, Juliet IR - Newson J FIR - Smith, Jennifer IR - Smith J FIR - Carlton, Lindsay IR - Carlton L FIR - Legge, Nele IR - Legge N FIR - Beesley, Amanda IR - Beesley A FIR - Burgess, Laura IR - Burgess L FIR - Windrow, Joanne IR - Windrow J FIR - Iyamabo, Doris IR - Iyamabo D FIR - Reynolds, Carly IR - Reynolds C FIR - Nutting, Jessica IR - Nutting J FIR - Harizaj, Helen IR - Harizaj H FIR - Jayasekara, Shiranthi IR - Jayasekara S FIR - Kenala, Cynthia IR - Kenala C FIR - Nichols, Amy IR - Nichols A FIR - Clarke, Paul IR - Clarke P FIR - Scott, Samantha IR - Scott S FIR - Pocock, Lucy IR - Pocock L FIR - Myhill, Jasmine IR - Myhill J FIR - Nicholl, Richard IR - Nicholl R FIR - Okome, Trinity IR - Okome T FIR - Jaarour, Sara IR - Jaarour S FIR - Ali, Saima IR - Ali S FIR - Mughal, Kamaal IR - Mughal K FIR - Wilson, Helen IR - Wilson H FIR - Omolokun, Omotakin IR - Omolokun O FIR - Jones, Mollie IR - Jones M FIR - Johnson, Mark IR - Johnson M FIR - Postlethwaite, Catherine IR - Postlethwaite C FIR - Parish, Abby IR - Parish A FIR - Jones, Mollie IR - Jones M FIR - Melvin, Victoria IR - Melvin V FIR - Davies, Samantha IR - Davies S FIR - Scorrer, Tim IR - Scorrer T FIR - Le Poidevin, Alison IR - Le Poidevin A FIR - Gourin, Batia IR - Gourin B FIR - Banerjee, Jay IR - Banerjee J FIR - McClure, Zoe IR - McClure Z FIR - Hayman, Melanie IR - Hayman M FIR - Lloyd-Nash, Richard IR - Lloyd-Nash R FIR - Dickson, Holly IR - Dickson H FIR - Zipitis, Christos IR - Zipitis C FIR - Chadwick, Emily IR - Chadwick E FIR - Gilbody, Bethan IR - Gilbody B FIR - Williams, Claire IR - Williams C FIR - McDevitt, Helen IR - McDevitt H FIR - Sakonidou, Susanna IR - Sakonidou S FIR - Joyce, Lee Ann IR - Joyce LA FIR - Seshadri, Dinakar IR - Seshadri D FIR - O'Brien, Samantha IR - O'Brien S FIR - Lea, Charlotte IR - Lea C FIR - Bowen, Ruth IR - Bowen R FIR - Hayman, Melanie IR - Hayman M FIR - Smith, Coral IR - Smith C FIR - Rao, Bharathi IR - Rao B FIR - Reynolds, Adam IR - Reynolds A FIR - Carlisle, Roberta IR - Carlisle R FIR - Fleck, Olwen IR - Fleck O FIR - Horrocks, Michelle IR - Horrocks M FIR - McCullough, Sarah IR - McCullough S FIR - Scott, Chloe IR - Scott C FIR - Morgan, Natalie IR - Morgan N FIR - Gupta, Richa IR - Gupta R FIR - Strogen, Emma IR - Strogen E FIR - Middleton, Jennifer IR - Middleton J FIR - Oliver, Christina IR - Oliver C FIR - Knight, Ros IR - Knight R FIR - Zalewski, Stefan IR - Zalewski S FIR - Groombridge, Julie IR - Groombridge J FIR - Booth, Nicola IR - Booth N FIR - Jennings, Clare IR - Jennings C FIR - Varadan, Ramamoorthy Madhepalli IR - Varadan RM FIR - Stares, Jasmine IR - Stares J FIR - Burke, Katherine IR - Burke K FIR - Settle, Deborah IR - Settle D FIR - Brock, Paula IR - Brock P FIR - Bevan, Victoria IR - Bevan V FIR - Hobbs, Rachel IR - Hobbs R FIR - Kennea, Nigel IR - Kennea N FIR - Hayward, Naomi IR - Hayward N FIR - Gourin, Batia IR - Gourin B FIR - Banerjee, Jay IR - Banerjee J FIR - McClure, Zoe IR - McClure Z FIR - Cairns, Pamela IR - Cairns P FIR - Mahoney, Liam IR - Mahoney L FIR - Millett, Louise IR - Millett L FIR - Salgia, Sanjay IR - Salgia S FIR - Frankland, Lisa IR - Frankland L FIR - Poon, Kevin Chuen IR - Poon KC FIR - Natti, Murali IR - Natti M FIR - Davies, Alison IR - Davies A FIR - Argus, Brenda IR - Argus B FIR - Cousins, Ruth IR - Cousins R FIR - Day, Elizabeth IR - Day E FIR - Harikumar, Chidambara IR - Harikumar C FIR - Egginton, Dawn IR - Egginton D FIR - Brown, Lisa IR - Brown L FIR - Boel, Lieve IR - Boel L FIR - Chakraborty, Mallinath IR - Chakraborty M FIR - Elliott, Sian IR - Elliott S FIR - Bilkhu, Amarpal IR - Bilkhu A FIR - Vigni, Denise IR - Vigni D FIR - Merchant, Nazakat IR - Merchant N FIR - Narayanan, Sankara IR - Narayanan S FIR - Dawson, Clare IR - Dawson C FIR - Audu, Grace IR - Audu G FIR - Sevilla, Maria IR - Sevilla M FIR - Rao, Nischal IR - Rao N FIR - Spelman, Catherine IR - Spelman C FIR - Taylor, Leanne IR - Taylor L FIR - Vasu, Vimal IR - Vasu V FIR - Moloney, Claire IR - Moloney C FIR - Stark, Michael IR - Stark M FIR - Crawford, Tara IR - Crawford T FIR - Viswanathan, Rajesh IR - Viswanathan R FIR - Streeter, Aimi IR - Streeter A FIR - Booth, Nicola IR - Booth N FIR - Jennings, Clare IR - Jennings C FIR - Saeed, Shakir IR - Saeed S FIR - Daher, Fawaz IR - Daher F FIR - Maqsood, Choudhary IR - Maqsood C FIR - Owen, Hilary IR - Owen H EDAT- 2026/01/08 07:13 MHDA- 2026/02/06 06:42 PMCR- 2026/01/08 CRDT- 2026/01/08 00:10 PHST- 2025/10/18 00:00 [received] PHST- 2025/12/18 00:00 [accepted] PHST- 2026/02/06 06:42 [medline] PHST- 2026/01/08 07:13 [pubmed] PHST- 2026/01/08 00:10 [entrez] PHST- 2026/01/08 00:00 [pmc-release] AID - 10.1186/s13063-025-09403-7 [pii] AID - 9403 [pii] AID - 10.1186/s13063-025-09403-7 [doi] PST - epublish SO - Trials. 2026 Jan 8;27(1):106. doi: 10.1186/s13063-025-09403-7. PMID- 41501781 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jan 7 TI - Association between ultra-processed food consumption and odds of depression, stress, and anxiety in adolescent girls: a cross-sectional study. PG - 457 LID - 10.1186/s12889-025-26167-6 [doi] LID - 457 AB - BACKGROUND AND AIM: Mental disorders, including depression, anxiety, and stress, disproportionately affect adolescent girls, with dietary patterns emerging as modifiable risk factors. Ultra-processed food (UPF) consumption, prevalent among adolescents, may exacerbate these conditions. This study examines the association between UPF consumption and mental health outcomes in Iranian female adolescents. METHODS: In this cross-sectional study, 263 female adolescents aged 15-18 years from Tehran, Iran, were assessed. Dietary intake was measured using a validated 168-item food frequency questionnaire, with UPFs classified per the NOVA system and expressed as a percentage of total energy intake. Depression, anxiety, and stress were evaluated using the DASS-21 questionnaire. Multivariable logistic regression models estimated odds ratios (ORs) and 95% confidence intervals (CIs) across UPF consumption tertiles, adjusting for BMI and physical activity. RESULTS: Higher UPF consumption was significantly associated with increased odds of depression, stress, and anxiety. In fully adjusted models, participants in the highest UPF tertile had 3.69 times higher odds of depression (95% CI: 1.92-7.10, P trend < 0.001), 2.84 times higher odds of stress (95% CI: 1.49-5.41, P trend = 0.001), and 1.99 times higher odds of anxiety (95% CI: 1.10-3.66, P trend = 0.026) compared to the lowest tertile. CONCLUSION: Greater UPF consumption is associated with elevated odds of depression, stress, and anxiety in adolescent girls, underscoring the need for dietary interventions to mitigate mental health burdens in this vulnerable population. FAU - Jafari, Ali AU - Jafari A AD - Student Research Committee, Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Systematic Review and Meta-analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN), Tehran, Iran. FAU - Momenan, Mehrnaz AU - Momenan M AD - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Tehrani, Asal Neshatbini AU - Tehrani AN AD - Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran. FAU - Behrouz, Vahideh AU - Behrouz V AD - Department of Nutrition, Faculty of Public Health, Kerman University of Medical Sciences, Kerman, Iran. FAU - Yari, Zahra AU - Yari Z AD - Department of Nutrition Research, National Nutrition and Food Technology Research Institute and Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, West Arghavan St. Farahzadi Blvd., Sharake Qods, Tehran, Iran. zahrayari_nut@yahoo.com. LA - eng PT - Journal Article DEP - 20260107 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Adolescent MH - *Depression/epidemiology MH - *Anxiety/epidemiology MH - *Stress, Psychological/epidemiology MH - Food, Processed MH - Iran/epidemiology MH - *Fast Foods/statistics & numerical data MH - Risk Factors PMC - PMC12871020 OTO - NOTNLM OT - Adolescent girls OT - Anxiety OT - Depression OT - Stress OT - Ultra-processed foods COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the principles outlined in the Declaration of Helsinki and received ethical approval from the Ethics Committee of the National Nutrition and Food Technology Research Institute at Shahid Beheshti University of Medical Sciences, Tehran, Iran (ethics approval number 054577). Informed written consent was obtained from all participants prior to their inclusion in the study. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/08 07:12 MHDA- 2026/06/27 16:09 PMCR- 2026/01/07 CRDT- 2026/01/08 00:02 PHST- 2025/05/22 00:00 [received] PHST- 2025/12/30 00:00 [accepted] PHST- 2026/06/27 16:09 [medline] PHST- 2026/01/08 07:12 [pubmed] PHST- 2026/01/08 00:02 [entrez] PHST- 2026/01/07 00:00 [pmc-release] AID - 10.1186/s12889-025-26167-6 [pii] AID - 26167 [pii] AID - 10.1186/s12889-025-26167-6 [doi] PST - epublish SO - BMC Public Health. 2026 Jan 7;26(1):457. doi: 10.1186/s12889-025-26167-6. PMID- 41501689 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jan 7 TI - Development and psychometric validation of a questionnaire assessing perception and acceptance of micronutrient-fortified bouillon cubes among non-index household members aged >/= 15 years in northern Ghana. PG - 456 LID - 10.1186/s12889-025-26144-z [doi] LID - 456 AB - BACKGROUND: Micronutrient deficiencies remain a major public health issue in West Africa, contributing to anaemia, impaired cognitive development, and increased infection risk. Bouillon cubes, widely consumed in the region, offer a culturally appropriate means of micronutrient delivery. However, no validated instrument exists to assess the psychosocial and behavioural factors influencing household acceptance of fortified bouillon cubes. This study aimed to develop and validate a questionnaire to assess perceptions and acceptance of micronutrient-fortified bouillon cubes among non-index household members (NIHMs) in northern Ghana. METHODS: A 29-item questionnaire was developed based on the Theory of Planned Behaviour and the Health Belief Model. Development involved a literature review, expert consultation, and pretesting with 18 adults. The instrument included 26 five-point Likert-scale items and 3 categorical items. One NIHM (i.e., household members aged >/= 15 years who were not enrolled as primary trial participants) was randomly selected per household using the Kish method. The questionnaire was administered to 742 NIHMs within 1-2 months of intervention initiation in a double-blind randomised controlled trial comparing multiple micronutrient-fortified versus iodine-only bouillon cubes in Kumbungu and Tolon districts. Of these, 731 NIHMs were retained for analysis, with the dataset divided into exploratory (n = 292) and confirmatory (n = 439) factor analyses. Psychometric properties were evaluated using Cronbach's alpha, composite reliability (CR), and average variance extracted (AVE). RESULTS: Participants (mean age = 40.8 +/- 17.4 years) were 58.8% female, 74.8% without formal education, and 38.4% were the primary household cooks. Exploratory factor analysis identified two constructs, Perception (8 items) and Acceptance (11 items), explaining 56% of variance. Confirmatory factor analysis retained 18 items (Perception = 8; Acceptance = 10) and showed good model fit (chi-square/df = 1.91, root mean square error of approximation [RMSEA] = 0.04, comparative fit index [CFI] = 0.98, Tucker-Lewis index [TLI] = 0.98, and standardized root mean square residual [SRMR] = 0.06). Internal consistency was acceptable (Cronbach's alpha: Perception = 0.71; Acceptance = 0.72; CR = 0.86 and 0.82, respectively). AVE was 0.52 for Perception and 0.46 for Acceptance. Discriminant validity was supported. CONCLUSION: The validated 18-item questionnaire shows acceptable psychometric properties and offers a standardised tool for assessing household perception and acceptance of fortified foods, suitable for programme design, evaluation, and behavioural monitoring in bouillon-consuming settings. FAU - Kyereh, Felix Kwaku AU - Kyereh FK AUID- ORCID: 0009-0005-4364-330X AD - Department of Nutrition and Food Science, University of Ghana, Legon, Accra, Ghana. kyerehfelix0238@yahoo.com. FAU - Ohemeng, Agartha N AU - Ohemeng AN AUID- ORCID: 0000-0002-7986-1350 AD - Department of Nutrition and Food Science, University of Ghana, Legon, Accra, Ghana. FAU - Engle-Stone, Reina AU - Engle-Stone R AUID- ORCID: 0000-0003-2446-6166 AD - Department of Nutrition and Institute for Global Nutrition, University of California, Davis, CA, USA. FAU - Wessells, K Ryan AU - Wessells KR AD - Department of Nutrition and Institute for Global Nutrition, University of California, Davis, CA, USA. FAU - Kumordzie, Sika M AU - Kumordzie SM AD - Department of Nutrition and Institute for Global Nutrition, University of California, Davis, CA, USA. FAU - Arnold, Charles D AU - Arnold CD AUID- ORCID: 0000-0001-6510-3172 AD - Department of Nutrition and Institute for Global Nutrition, University of California, Davis, CA, USA. FAU - Davis, Jennie N AU - Davis JN AD - Department of Nutrition and Institute for Global Nutrition, University of California, Davis, CA, USA. FAU - Becher, Emily R AU - Becher ER AD - Department of Nutrition and Institute for Global Nutrition, University of California, Davis, CA, USA. FAU - Fuseini, Ahmed D AU - Fuseini AD AD - Department of Nutrition and Food Science, University of Ghana, Legon, Accra, Ghana. FAU - Nyaaba, Kania W AU - Nyaaba KW AD - Department of Nutrition and Food Science, University of Ghana, Legon, Accra, Ghana. FAU - Tan, Xiuping AU - Tan X AD - Department of Nutrition and Institute for Global Nutrition, University of California, Davis, CA, USA. FAU - Vosti, Stephen A AU - Vosti SA AD - Department of Nutrition and Institute for Global Nutrition, University of California, Davis, CA, USA. AD - Department of Agricultural and Resource Economics, University of California, Davis, CA, USA. FAU - Adu-Afarwuah, Seth AU - Adu-Afarwuah S AD - Department of Nutrition and Food Science, University of Ghana, Legon, Accra, Ghana. LA - eng GR - INV-007916/GATES/Gates Foundation/United States PT - Journal Article PT - Validation Study DEP - 20260107 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Ghana MH - Female MH - *Micronutrients/administration & dosage MH - Surveys and Questionnaires/standards MH - Male MH - Adult MH - Psychometrics MH - Adolescent MH - Middle Aged MH - *Food, Fortified MH - Young Adult MH - Reproducibility of Results MH - Aged PMC - PMC12870002 OTO - NOTNLM OT - Fortified bouillon cubes OT - Ghana OT - Micronutrient deficiencies OT - Perception and acceptance OT - Public health nutrition OT - Questionnaire validation COIS- Declarations. Ethics approval and consent to participate: Ethical approval for this study was obtained from the Ghana Health Service Ethical Review Committee (GHSERC ID: 024/11/21), the Institutional Review Board at the University of California, Davis (IRB ID: 1837253), and the Ghana Food and Drugs Authority (Certificate No. FDA/CT/2213 [1]). The trial was registered at ClinicalTrials.gov (NCT05178407) and the Pan-African Clinical Trials Registry (PACTR202206868437931). Written informed consent was obtained from all participants prior to their involvement in the study. For participants under 18 years of age, assent was obtained in addition to parental or caregiver consent. All procedures were conducted in accordance with relevant guidelines and regulations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/08 00:27 MHDA- 2026/06/27 00:49 PMCR- 2026/01/07 CRDT- 2026/01/07 23:57 PHST- 2025/06/25 00:00 [received] PHST- 2025/12/29 00:00 [accepted] PHST- 2026/06/27 00:49 [medline] PHST- 2026/01/08 00:27 [pubmed] PHST- 2026/01/07 23:57 [entrez] PHST- 2026/01/07 00:00 [pmc-release] AID - 10.1186/s12889-025-26144-z [pii] AID - 26144 [pii] AID - 10.1186/s12889-025-26144-z [doi] PST - epublish SO - BMC Public Health. 2026 Jan 7;26(1):456. doi: 10.1186/s12889-025-26144-z. PMID- 41500800 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260813 IS - 1468-330X (Electronic) IS - 0022-3050 (Print) IS - 0022-3050 (Linking) VI - 97 IP - 4 DP - 2026 Mar 13 TI - Telomere length as a marker of biological age in paediatric multiple sclerosis. PG - 302-308 LID - 10.1136/jnnp-2025-336736 [doi] AB - BACKGROUND: Increased chronological age correlates with reduced relapse rates and increased disability in multiple sclerosis (MS). Biological age may better capture ageing's impact on MS and might accelerate due to MS itself. Establishing accelerated biological ageing in adults is complicated by normal ageing and comorbidities. Telomere length, a well-recognised biological ageing marker, is shortened in adults with MS and associated with disability. Demonstrating accelerated biological ageing in paediatric-onset MS (POMS) would strengthen the hypothesis that MS drives premature biological ageing. This study aimed to determine if telomere length differs in POMS compared to age-similar healthy controls. METHODS: We performed a cross-sectional case-control study of whole blood samples and clinical data from The US Network of Pediatric MS Centers. Real-time quantitative PCR measured telomere length, expressed as a telomere to somatic DNA ratio (T/S ratio). T/S ratio was compared between cases and age-similar healthy controls using multivariate regression analysis adjusting for chronological age, sex, race, ethnicity, tobacco exposure, socioeconomic status and body mass index. RESULTS: We analysed 300 POMS cases and 200 controls. The unadjusted mean T/S ratios were 1.66 (SD 0.32) for cases and 1.71 (SD 0.29) for controls (mean difference -0.05, 95% CI -0.10 to 0.01, p=0.08). After adjusting for key covariables with face validity, POMS participants had a mean 0.086 shorter T/S ratio than controls (95% CI 0.015 to 0.157, p=0.018). CONCLUSIONS: POMS participants demonstrated shorter telomeres than age-similar controls in a multivariable model adjusting for sociodemographic variables, suggesting that MS may contribute to accelerated biological ageing. CI - (c) Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Jacques, Kayla AU - Jacques K AUID- ORCID: 0009-0006-3841-6142 AD - Department of Neurosciences, University of California San Diego, La Jolla, California, USA. FAU - Race, Jonathan AU - Race J AD - Pediatrics, The University of Utah, Salt Lake City, Utah, USA. FAU - Goyne, Christopher AU - Goyne C AD - Department of Neurosciences, University of California San Diego, La Jolla, California, USA. FAU - Fair, Ashley AU - Fair A AD - Department of Neurosciences, University of California San Diego, La Jolla, California, USA. AD - Boston University, Boston, Massachusetts, USA. FAU - Schuette, Allison AU - Schuette A AD - Pediatrics, The University of Utah, Salt Lake City, Utah, USA. FAU - Yang, Jennifer H AU - Yang JH AD - Department of Neurosciences, University of California San Diego, La Jolla, California, USA. FAU - Caillier, Stacy AU - Caillier S AD - University of California San Francisco, San Francisco, California, USA. FAU - Aaen, Gregory Scott AU - Aaen GS AUID- ORCID: 0000-0002-0408-2053 AD - Loma Linda University, Loma Linda, California, USA. FAU - Abrams, Aaron AU - Abrams A AUID- ORCID: 0000-0002-4607-5740 AD - Neurology, Cleveland Clinic, Cleveland, Ohio, USA. FAU - Benson, Leslie AU - Benson L AD - Neurology, Childrens Hospital Boston, Boston, Massachusetts, USA. FAU - Casper, T Charles AU - Casper TC AD - Pediatrics, The University of Utah, Salt Lake City, Utah, USA. FAU - Chitnis, Tanuja AU - Chitnis T AD - Harvard Medical School, Boston, Massachusetts, USA. FAU - Gorman, Mark P AU - Gorman MP AD - Childrens Hospital Boston, Boston, Massachusetts, USA. FAU - Lotze, Tim AU - Lotze T AD - Baylor College of Medicine, Houston, Texas, USA. FAU - Krupp, Lauren AU - Krupp L AUID- ORCID: 0000-0001-7003-807X AD - Pediatric MS Center, NYU Langone Health, New York, New York, USA. FAU - Mar, Soe AU - Mar S AD - Department of Neurology, Washington University in Saint Louis, St. Louis, Missouri, USA. FAU - Ness, Jayne AU - Ness J AD - University of Alabama at Birmingham, Birmingham, Alabama, USA. FAU - Rensel, Mary AU - Rensel M AD - Cleveland Clinic, Cleveland, Ohio, USA. FAU - Rodriguez, Moses AU - Rodriguez M AD - Neurology, Mayo Clinic Rochester, Rochester, Minnesota, USA. AD - Mayo Clinic, Rochester, Minnesota, USA. FAU - Rose, John AU - Rose J AD - University of Utah Health, Salt Lake City, Utah, USA. FAU - Schreiner, Teri AU - Schreiner T AD - Department of Neurology, University of Colorado, Aurora, Colorado, USA. FAU - Tillema, Jan-Mendelt AU - Tillema JM AD - Mayo Clinic, Rochester, Minnesota, USA. FAU - Waldman, Amy AU - Waldman A AD - The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. FAU - Wheeler, Yolanda AU - Wheeler Y AUID- ORCID: 0000-0003-1391-4496 AD - Department of Nursing, University of Alabama at Birmingham, Birmingham, Alabama, USA. FAU - Oksenberg, Jorge AU - Oksenberg J AD - University of California San Francisco, San Francisco, California, USA. FAU - Lin, Jue AU - Lin J AD - University of California San Francisco, San Francisco, California, USA. FAU - Waubant, Emmanuelle AU - Waubant E AD - University of California San Francisco, San Francisco, California, USA. FAU - Graves, Jennifer S AU - Graves JS AD - Department of Neurosciences, University of California San Diego, La Jolla, California, USA jgraves@ucsd.edu. LA - eng GR - K12 NS098482/NS/NINDS NIH HHS/United States GR - R01 NS071463/NS/NINDS NIH HHS/United States PT - Journal Article DEP - 20260313 PL - England TA - J Neurol Neurosurg Psychiatry JT - Journal of neurology, neurosurgery, and psychiatry JID - 2985191R RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Male MH - Case-Control Studies MH - *Multiple Sclerosis/genetics MH - Cross-Sectional Studies MH - Child MH - *Aging/genetics MH - *Telomere MH - Adolescent MH - Biomarkers PMC - PMC13292612 MID - NIHMS2183613 OTO - NOTNLM OT - GENETICS OT - MULTIPLE SCLEROSIS OT - NEUROIMMUNOLOGY OT - PAEDIATRIC NEUROLOGY COIS- Competing interests: MR has served as a speaker or consultant for Serono, Novartis, Genentech, Genzyme, Horizon, TG Therapeutics, Bristol Myers Squibb, Cycle and Sanofi, and has received funding from the National MS Society and Roche for research. EW has received institutional funding for research from the NIH, DoD, Race to Erase MS and NMSS, has received payment for lectures with NeurologyLive and Advanced Curriculum and has served on the advisory board for BMS and Roche. LK has received institutional funding for research from Biogen, Novartis, NIH, NMSS, consulting fees from F Hoffman/LaRoche, Biogen, WebMD/Medscape, Ebix, Gerson Lehrman, honouraria payment from BMS, expert testimony payment from MCIC Vermont, Kaufman Borgeest & Ryan LLP (KBR, LLP) and Sedgwick CMS, Inc, meeting attendance support from BMS/Celgene, has served on the advisory board for Biogen, Novartis and Genentech, has had leadership roles with the International Paediatric MS Study Group, US Network of Paediatric MS Centres, iWiMS and IMSCOGS. JHY has received grant funding from the NIH, consulting fees from Kyowa Kirin, payment for speaking fees from UCB, personal honouraria from the American College of Rheumatology and support for meeting attendance from the NIH. TS has received support for meeting attendance from Hoffman La Roche and participates on the advisory board for Biogen. JR has received grant funding from NMSS, Biogen, PCORI/NIH, Guthy Jackson Charitable Foundation and The VA. TC is supported by grant funding from NIH, NMSS, Massachusetts Life Sciences Center, DoD, Novartis Pharmaceuticals Corporation, Tiziana Therapeutics, Wesley Clover International and Genentech, Inc. Celgene Corp, Sumaira Foundation, Brainstorm Cell Therapeutics, Bristol Myers Squibb, EMD Serono, I-Mab Biopharma, Mallinckrodt ARD, Octave Bioscience, Sanofi and Genzyme; she has received consulting fees (payment made to the institution) from Genentech, Inc., Janssen Research & Development, LLC., Novartis Pharmaceuticals Corporation and Siemens Healthcare Diagnostics Inc., Banner Life Sciences, Biogen, Bristol Myers Squibb, Octave Bioscience, Sandoz, Siemens, TG Therapeutics, UCB and Vida Ventures; payment or honouraria for lectures, presentations, speakers bureaus, manuscript writing or educational events was received from Genentech, Inc., MJH Life Sciences, Prime Education, LLC, and Novartis Pharmaceuticals Corporation; she participates on a Data Safety Monitoring Board or Advisory Board for Bristol Myers Squibb, Genentech, Inc., Novartis Pharmaceuticals Corporation, Octave Bioscience, Inc., Roche, Sanofi US Services, Inc. JSG has received grant funding from Octave Biosciences and Sanofi. EDAT- 2026/01/08 00:27 MHDA- 2026/03/14 00:31 PMCR- 2026/06/24 CRDT- 2026/01/07 21:13 PHST- 2025/05/20 00:00 [received] PHST- 2025/10/26 00:00 [accepted] PHST- 2026/03/14 00:31 [medline] PHST- 2026/01/08 00:27 [pubmed] PHST- 2026/01/07 21:13 [entrez] PHST- 2026/06/24 00:00 [pmc-release] AID - jnnp-2025-336736 [pii] AID - 10.1136/jnnp-2025-336736 [doi] PST - epublish SO - J Neurol Neurosurg Psychiatry. 2026 Mar 13;97(4):302-308. doi: 10.1136/jnnp-2025-336736. PMID- 41500637 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 16 IP - 1 DP - 2026 Jan 6 TI - Schulthess Clinic Zurich Shoulder Instability Registry: a local registry for multimodal data collection and enhanced care. PG - e105453 LID - 10.1136/bmjopen-2025-105453 [doi] LID - e105453 AB - PURPOSE: The Shoulder Instability Registry (SIR) was established in 2019 to systematically capture and monitor outcomes following surgical treatment of shoulder instability (SI). The aim of this cohort profile is to describe the purpose, design, data structure and baseline characteristics of the SIR, and to outline how the registry supports longitudinal assessment of safety, functional recovery, quality of life and patient-reported outcomes after surgical treatment of SI. PARTICIPANTS: The registry includes all patients treated surgically for SI. Data collection includes medical history of instability, surgical techniques and intraoperative findings. Clinical assessments include range of motion, instability-specific tests, hyperlaxity signs, Constant Score, subjective shoulder value and SI-specific scores such as the ROWE Score and the Western Ontario Shoulder Instability Index. Radiological evaluations included initial and follow-up imaging via X-rays and CT to assess bony lesions and SI-related arthropathy, as well as MRI for soft tissue injuries. Data are documented preoperatively, at 6 months and at 24 months postoperatively. Although the SIR is an observational cohort rather than a randomised clinical trial, treatment effectiveness is evaluated through longitudinal changes in validated patient-reported outcomes, clinical performance measures and imaging findings. FINDINGS TO DATE: Between January 2019 and December 2024, 668 patients have been registered (mean age 31 years, 82% men, mean body mass index of 25). According to the American Association of Anesthesiology (ASA) Classification, 66% of patients were classified as ASA I, 33% as ASA II and only 1% as ASA III. 69% of admissions were due to accidents and 31% due to illness. Mean surgery duration was 75 min, and the median hospital stay was 2 days. 38% of patients were insured privately and had general insurance in 62%. 85% of cases were treated arthroscopically, and 15% were treated openly. Baseline clinical scores showed a mean Constant Score of 77 points, mean subjective shoulder value of 49%, mean ROWE Score of 46 points and mean Western Ontario Shoulder Instability Index of 53. Based on Gerber's classification, 68% of cases were type B2, 29% B3, 2% B5 and fewer than 2% were classified as B4 or B1. 85% of cases suffered from anterior instability, while only 13% experienced posterior instability, the remaining 2% showed multidirectional instability. Among posterior cases, Moroder's classification identified 58% as type B2, 19% as A2, 7% as A1, 6% as B1, 6% as C1 and 4% as C2. Regarding osteochondral lesions, 20% showed none, 31% showed a glenoid defect, 54% showed a Hill-Sachs lesion and 13% showed a cartilage defect. Scheibel's classification identified glenoid defects as type 3a in 38% of cases, type 2 in 24%, type 1a in 13% of cases, type 3b in 11%, type 1b in 8% and type 1c in 5% of cases. Positive Gagey and Walch signs were observed in 29% and 27% of cases, respectively. Dislocations presented as primary events in 24% of cases, while 76% were recurrent. Surgical interventions included 459 (70%) Bankart repairs, 6 Bankart plus repairs (<1%) and 108 (16%) Remplissage procedures for soft tissue stabilisation. Bony reconstructions included 52 fragment fixations (8%), 41 coracoid transfers (6%) and 87 iliac crest bone grafts (13%). Additional pathologies were addressed in 533 cases (81%), while 38 cases required revision surgery. FUTURE PLANS: We will continue prospectively enrolling and monitoring patients that receive surgical treatment of SI. There are no current plans to halt the data collection in the near future, thereby consistently increasing the number of patients in the registry. A larger availability of data will additionally allow us to apply machine learning modelling and develop risk-prediction tools with the goal of aiding surgical decision making. CI - (c) Author(s) (or their employer(s)) 2026. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Schneller, Tim AU - Schneller T AUID- ORCID: 0009-0007-6949-9849 AD - Department for Shoulder and Elbow Surgery, Schulthess Klinik, Zurich, Switzerland tim.schneller@kws.ch. FAU - Delliehausen, Nadja AU - Delliehausen N AD - Department for Shoulder and Elbow Surgery, Schulthess Klinik, Zurich, Switzerland. FAU - Brune, Daniela AU - Brune D AD - Department for Shoulder and Elbow Surgery, Schulthess Klinik, Zurich, Switzerland. FAU - Bohm, Elisabeth AU - Bohm E AD - Department for Shoulder and Elbow Surgery, Schulthess Klinik, Zurich, Switzerland. FAU - Moroder, Philipp AU - Moroder P AD - Department for Shoulder and Elbow Surgery, Schulthess Klinik, Zurich, Switzerland. FAU - Lazaridou, Asimina AU - Lazaridou A AD - Department for Shoulder and Elbow Surgery, Schulthess Klinik, Zurich, Switzerland. AD - Department of Anesthesiology, Brigham and Women's Hospital, Boston, Massachusetts, USA. FAU - Scheibel, Markus AU - Scheibel M AD - Department for Shoulder and Elbow Surgery, Schulthess Klinik, Zurich, Switzerland. AD - Center for Musculoskeletal Surgery, Charite - Universitatsmedizin Berlin, Berlin, Germany. LA - eng PT - Journal Article DEP - 20260106 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Registries MH - *Joint Instability/surgery MH - Adult MH - Male MH - *Shoulder Joint/surgery/physiopathology/diagnostic imaging MH - Female MH - Patient Reported Outcome Measures MH - Young Adult MH - Adolescent MH - Range of Motion, Articular MH - Treatment Outcome MH - Middle Aged MH - Data Collection MH - Quality of Life PMC - PMC12778285 OTO - NOTNLM OT - Patient Reported Outcome Measures OT - REGISTRIES OT - Shoulder COIS- Competing interests: MS is a paid consultant of and receives royalties from Stryker. PM is a paid consultant of and receives royalties from Arthrex. All other authors have no competing interest to declare. EDAT- 2026/01/08 00:27 MHDA- 2026/01/08 00:28 PMCR- 2026/01/06 CRDT- 2026/01/07 20:43 PHST- 2026/01/08 00:28 [medline] PHST- 2026/01/08 00:27 [pubmed] PHST- 2026/01/07 20:43 [entrez] PHST- 2026/01/06 00:00 [pmc-release] AID - bmjopen-2025-105453 [pii] AID - 10.1136/bmjopen-2025-105453 [doi] PST - epublish SO - BMJ Open. 2026 Jan 6;16(1):e105453. doi: 10.1136/bmjopen-2025-105453. PMID- 41500389 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 1878-1632 (Electronic) IS - 1529-9430 (Linking) VI - 26 IP - 5 DP - 2026 May TI - Is chronic low back pain related to sleep disturbances? A self-organizing maps for unsupervised machine learning-based patient phenotyping. PG - 1014-1024 LID - S1529-9430(26)00003-3 [pii] LID - 10.1016/j.spinee.2026.01.007 [doi] AB - BACKGROUND CONTEXT: Chronic low back pain (CLBP) is a multifactorial condition and a leading cause of disability worldwide. Among the various contributors to symptom persistence, sleep quality has emerged as a critical yet underexplored factor. Evidence suggests a bidirectional relationship between poor sleep and pain intensity, disability, and psychological distress in individuals with CLBP. PURPOSE: To explore the relationship between sleep quality and CLBP using machine learning techniques, specifically the Self-Organizing Map (SOM) algorithm, while accounting for demographic, clinical, psychosocial, and occupational factors. STUDY DESIGN/SETTING: This was a cross-sectional study conducted at Campus Bio-Medico Hospital Foundation in Rome, Italy, between July 2024 and January 2025. PATIENT SAMPLE: The study included 279 adult working patients (aged 18-65) with a clinical diagnosis of CLBP due to degenerative causes, all of whom were candidates for conservative treatment. Patients with cancer, trauma, spinal deformities, or infections were excluded. OUTCOME MEASURES: Pain intensity was assessed using the Visual Analog Scale (VAS), while sleep quality was measured with the Pittsburgh Sleep Quality Index (PSQI), a validated tool capturing various dimensions of sleep disturbance. Disability related to low back pain was evaluated using the Oswestry Disability Index (ODI). Depressive symptoms were identified using the Patient Health Questionnaire-2 (PHQ-2). Functional outcomes included assessment of work capacity through the Work Ability Index (WAI) and activity limitations via the Nordic Musculoskeletal Questionnaire, focusing on how often back pain interfered with usual daily activities. METHODS: Validated questionnaires and anthropometric data were collected. SOM, an unsupervised machine learning algorithm, was applied to detect clusters based on multidimensional patient data. Subsequent k-means clustering was used to define patient subgroups. Statistical comparisons between clusters were performed using Kruskal-Wallis and chi-squared tests. Multiple imputation addressed missing data. RESULTS: A total of 4 distinct patient clusters were identified. Cluster 1 included physically active individuals with moderate pain and no depression. Cluster 2 consisted of highly educated women with sedentary jobs and minimal disability. Cluster 3 showed the worst outcomes: high pain intensity, severe disability, depression, and the poorest sleep quality. Cluster 4, composed entirely of men, showed high work ability, good sleep, low pain, and no depressive symptoms. Poor sleep quality correlated strongly with depressive symptoms, high pain, disability, and reduced work capacity. These associations persisted even when sleep was excluded from clustering inputs, confirming its predictive linkage. CONCLUSIONS: Sleep quality is a key determinant in the clinical profile of CLBP patients. Poor sleep is closely associated with worse pain perception, psychological distress, and functional impairment. SOM analysis revealed hidden patterns not captured by traditional methods. Integrating sleep evaluation into multidisciplinary care models may improve outcomes for CLBP patients. Longitudinal studies are needed to clarify the directionality of these effects. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Petrucci, Giorgia AU - Petrucci G AD - Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy. FAU - Russo, Simone AU - Russo S AD - Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Italian Workers' Compensation Authority (INAIL), Rome, Italy. FAU - Russo, Fabrizio AU - Russo F AD - Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy; Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Universita Campus Bio-Medico di Roma, Rome, Italy. Electronic address: fabrizio.russo@policlinicocampus.it. FAU - Vadala, Gianluca AU - Vadala G AD - Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy; Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Universita Campus Bio-Medico di Roma, Rome, Italy. FAU - Marchetti, Anna AU - Marchetti A AD - Research Unit of Nursing Palliative Care, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, 00128, Italy; Department of Medicine and Surgery, Research Unit of Nursing Science, University Campus Bio-Medico di Roma, Rome, 00128, Italy. FAU - Piredda, Michela AU - Piredda M AD - Department of Medicine and Surgery, Research Unit of Nursing Science, University Campus Bio-Medico di Roma, Rome, 00128, Italy. FAU - Iavicoli, Sergio AU - Iavicoli S AD - General Directorate for Prevention, Ministry of Health, Rome, Italy. FAU - De Marinis, Maria Grazia AU - De Marinis MG AD - Research Unit of Nursing Palliative Care, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, 00128, Italy; Department of Medicine and Surgery, Research Unit of Nursing Science, University Campus Bio-Medico di Roma, Rome, 00128, Italy. FAU - Papalia, Rocco AU - Papalia R AD - Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy; Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Universita Campus Bio-Medico di Roma, Rome, Italy. FAU - Denaro, Vincenzo AU - Denaro V AD - Operative Research Unit of Orthopaedic and Trauma Surgery, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, Italy. LA - eng PT - Journal Article DEP - 20260105 PL - United States TA - Spine J JT - The spine journal : official journal of the North American Spine Society JID - 101130732 SB - IM MH - Humans MH - *Low Back Pain/complications/etiology MH - Female MH - Adult MH - Male MH - Cross-Sectional Studies MH - Middle Aged MH - *Sleep Wake Disorders/complications MH - *Unsupervised Machine Learning MH - Phenotype MH - *Chronic Pain/complications MH - Pain Measurement MH - Young Adult MH - Sleep Quality MH - Disability Evaluation MH - Clustering Algorithms MH - Aged MH - Adolescent OTO - NOTNLM OT - Chronic low back pain OT - Depression OT - Disability OT - Pain intensity OT - Psychosocial factors OT - Sleep quality OT - Work ability COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/08 00:26 MHDA- 2026/04/26 05:13 CRDT- 2026/01/07 19:16 PHST- 2025/07/09 00:00 [received] PHST- 2025/12/03 00:00 [revised] PHST- 2026/01/03 00:00 [accepted] PHST- 2026/04/26 05:13 [medline] PHST- 2026/01/08 00:26 [pubmed] PHST- 2026/01/07 19:16 [entrez] AID - S1529-9430(26)00003-3 [pii] AID - 10.1016/j.spinee.2026.01.007 [doi] PST - ppublish SO - Spine J. 2026 May;26(5):1014-1024. doi: 10.1016/j.spinee.2026.01.007. Epub 2026 Jan 5. PMID- 41500192 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260818 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 10 DP - 2026 Jan 7 TI - Using AI Chatbot to Assist Students' Behavior Management for Obesity Prevention in Middle Schools: Feasibility Study. PG - e83630 LID - 10.2196/83630 [doi] LID - e83630 AB - BACKGROUND: Adolescent obesity remains a pressing public health challenge, particularly among socioeconomically disadvantaged populations. Artificial intelligence (AI) holds the promise for supporting students in managing daily health behaviors, but few existing studies used AI-based interventions in naturalistic settings such as schools. OBJECTIVE: This study evaluated the feasibility and preliminary impact of ProudMe Tech (Louisiana State University), an AI-assisted web app designed to help students manage 4 obesity-related behaviors: physical activity, screen time, diet, and sleep. METHODS: The 8-week, 1-arm pilot intervention study recruited 172 participants from 5 middle schools in Louisiana and used the ProudMe Tech to set behavior goals, track behaviors, record reflections, and receive AI-generated feedback. Both engagement (primary focus) and behavior impacts (secondary focus) were examined. RESULTS: Engagement metrics indicated varying levels of usage, averaging 8.9 (SD 7.6) behavior entries and 30.0 (SD 28.3) reflections per student, and receiving 33.5 (SD 29.7) AI feedback messages. Overall, participants recorded 6164 valid daily goals, of which 3934 (63.8%) were achieved. Natural language processing of the reflections and AI feedback messages revealed an overall neutral to positive sentiment. Pre- to postcomparisons showed (1) a significant reduction in screen time from 4.3 (SD 2.6) to 3.4 (SD 2.5) hours per day (21.6% decrease; t164=6.18, P<.001), (2) a small but significant decrease in fruit and vegetable intake from 5.7 (SD 3.8) to 5.2 (SD 3.5) servings per day (8.9% decrease; t169=2.27, P=.46), and (3) no significant changes in physical activity and sleep. CONCLUSIONS: These findings suggest that ProudMe Tech is a feasible AI chatbot that can engage adolescents in health behavior management, but more adaptation is needed to effectively elicit improvements in health behaviors and lower the obesity risk in middle school students. CI - (c) Qiaoyin Tan, Yuxin Nie, Paul Son, Yizhou Qian, Amanda E Staiano, Fahui Wang, Richard R Rosenkranz, Senlin Chen. Originally published in JMIR Formative Research (https://formative.jmir.org). FAU - Tan, Qiaoyin AU - Tan Q AUID- ORCID: 0009-0004-5386-2955 AD - School of Kinesiology, Louisiana State University, 2124 HPL Field House, Baton Rouge, LA, 70803, United States, 1 (225) 5787995, 1 (225) 5783680. FAU - Nie, Yuxin AU - Nie Y AUID- ORCID: 0009-0007-2112-9259 AD - School of Kinesiology, Louisiana State University, 2124 HPL Field House, Baton Rouge, LA, 70803, United States, 1 (225) 5787995, 1 (225) 5783680. FAU - Son, Paul AU - Son P AUID- ORCID: 0009-0000-4212-7796 AD - School of Kinesiology, Louisiana State University, 2124 HPL Field House, Baton Rouge, LA, 70803, United States, 1 (225) 5787995, 1 (225) 5783680. FAU - Qian, Yizhou AU - Qian Y AUID- ORCID: 0000-0002-5362-2634 AD - School of Kinesiology, Louisiana State University, 2124 HPL Field House, Baton Rouge, LA, 70803, United States, 1 (225) 5787995, 1 (225) 5783680. FAU - Staiano, Amanda E AU - Staiano AE AUID- ORCID: 0000-0001-7846-046X AD - Pennington Biomedical Research Center, Baton Rouge, LA, United States. FAU - Wang, Fahui AU - Wang F AUID- ORCID: 0000-0001-7765-3024 AD - Department of Geography & Anthropology, Louisiana State University, Baton Rouge, LA, United States. FAU - Rosenkranz, Richard R AU - Rosenkranz RR AUID- ORCID: 0000-0002-8242-3546 AD - Department of Kinesiology & Nutrition Sciences, University of Nevada, Las Vegas, NV, United States. FAU - Chen, Senlin AU - Chen S AUID- ORCID: 0000-0003-0945-4271 AD - School of Kinesiology, Louisiana State University, 2124 HPL Field House, Baton Rouge, LA, 70803, United States, 1 (225) 5787995, 1 (225) 5783680. LA - eng GR - R15 HD108765/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260107 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Feasibility Studies MH - Adolescent MH - Female MH - *Students/psychology/statistics & numerical data MH - Male MH - Pilot Projects MH - Louisiana MH - Schools/organization & administration/statistics & numerical data MH - *Pediatric Obesity/prevention & control MH - *Artificial Intelligence/standards MH - Health Behavior MH - Exercise PMC - PMC12788712 OTO - NOTNLM OT - adolescence health OT - behavior intervention OT - large language models OT - mobile health OT - school-based COIS- Conflicts of Interest: None declared. EDAT- 2026/01/08 00:26 MHDA- 2026/01/08 00:27 PMCR- 2026/01/07 CRDT- 2026/01/07 18:12 PHST- 2025/09/05 00:00 [received] PHST- 2025/12/02 00:00 [accepted] PHST- 2026/01/08 00:27 [medline] PHST- 2026/01/08 00:26 [pubmed] PHST- 2026/01/07 18:12 [entrez] PHST- 2026/01/07 00:00 [pmc-release] AID - v10i1e83630 [pii] AID - 83630 [pii] AID - 10.2196/83630 [doi] PST - epublish SO - JMIR Form Res. 2026 Jan 7;10:e83630. doi: 10.2196/83630. PMID- 41499911 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 1872-7727 (Electronic) IS - 0720-048X (Linking) VI - 195 DP - 2026 Feb TI - Acceleration of chemical shift encoding-based water-fat imaging for pancreatic proton density fat fraction mapping in a single breath-hold: Data from the LION study. PG - 112641 LID - S0720-048X(25)00727-2 [pii] LID - 10.1016/j.ejrad.2025.112641 [doi] AB - PURPOSE: With the rising prevalence of obesity and metabolic syndrome, there is an increasing need for noninvasive quantification of pancreatic fat as a marker of metabolic risk. Chemical shift encoding (CSE)-based water-fat separation enables pancreatic proton density fat fraction (PDFF) mapping. This study evaluates techniques for accelerating high-resolution, single-breath-hold PDFF mapping using sparse sampling with compressed sensing with sensitivity encoding (C-SENSE) and a deep learning (DL)-assisted reconstruction algorithm, focusing on reproducibility, precision, and clinical applicability. METHODS: 104 abdominal MRI datasets were obtained from 71 adults (58 % female; age 18-65 years; body mass index (BMI) 30.0-39.9 kg/m(2); without diabetes) enrolled in a lifestyle intervention trial. Imaging was performed at 3 T (Ingenia Elition X, Philips) using two six-echo gradient-echo acquisitions (2 x 2 x 3 mm(3), identical TR/TE/echo spacing). Acceleration factors of R = 6 (16.9 s) and R = 10 (10.3 s) were reconstructed using vendor compressed sensing (C-SENSE6, C-SENSE10); the DL-assisted reconstruction (C-SENSE AI10) was applied only to R = 10 to evaluate denoising of higher-acceleration data. PDFF maps were analyzed using three regional regions of interest (ROIs) (head, body, tail) and whole-pancreas segmentation. RESULTS: A Mean pancreatic PDFF measured with C-SENSE6 was 15.0 [10.9 - 23.0] % at baseline (V1) and 8.2 [7.1 - 11.4] % after one year (V3). Across all reconstructions, PDFF ranged 3.5 - 47.6 %. Strong linearity was observed between C-SENSE10 and C-SENSE AI10 compared with C-SENSE6 (R(2) >/= 0.99). Whole-pancreas analysis showed high reproducibility (intraclass correlation coefficient = 0.87 - 1.00 across methods). The DL-assisted reconstruction reduced map noise compared with conventional C-SENSE10 without affecting PDFF accuracy. CONCLUSION: Accelerated CSE-based pancreatic PDFF mapping enables precise, reproducible, and clinically feasible single-breath-hold fat quantification. The approach provides a robust tool for evaluating pancreatic steatosis in obesity and metabolic disease research. CI - Copyright (c) 2025 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Rupp, Selina AU - Rupp S AD - Institute for Diagnostic and Interventional Radiology, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Han, Jessie AU - Han J AD - Institute for Diagnostic and Interventional Radiology, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Naebauer, Stella Marlene AU - Naebauer SM AD - Institute for Diagnostic and Interventional Radiology, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Weiss, Kilian AU - Weiss K AD - Philips GmbH Market DACH, Hamburg, Germany. FAU - Peeters, Johannes M AU - Peeters JM AD - Philips Healthcare, Best, Netherlands. FAU - Makowski, Marcus M AU - Makowski MM AD - Institute for Diagnostic and Interventional Radiology, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Reik, Anna AU - Reik A AD - Institute for Nutritional Medicine, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Hauner, Hans AU - Hauner H AD - Institute for Nutritional Medicine, School of Medicine and Health, Technical University of Munich, Munich, Germany; Else Kroener-Fresenius-Center of Nutritional Medicine, School of Life Sciences, Technical University of Munich, Freising, Germany. FAU - Holzapfel, Christina AU - Holzapfel C AD - Institute for Nutritional Medicine, School of Medicine and Health, Technical University of Munich, Munich, Germany; Department of Nutritional, Food and Consumer Sciences, Fulda University of Applied Sciences, Fulda, Germany. FAU - Junker, Daniela AU - Junker D AD - Institute for Diagnostic and Interventional Radiology, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Burian, Egon AU - Burian E AD - Institute for Diagnostic and Interventional Radiology, School of Medicine and Health, Technical University of Munich, Munich, Germany. FAU - Karampinos, Dimitrios C AU - Karampinos DC AD - Institute for Diagnostic and Interventional Radiology, School of Medicine and Health, Technical University of Munich, Munich, Germany; Laboratory of Magnetic Resonance Imaging Systems and Methods, Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland; CIBM Center for Biomedical Imaging (CIBM), Lausanne, Switzerland. FAU - Wu, Mingming AU - Wu M AD - Institute for Diagnostic and Interventional Radiology, School of Medicine and Health, Technical University of Munich, Munich, Germany; Department of Radiology, LMU University Hospital, Munich, Germany. Electronic address: mingming.wu@tum.de. LA - eng PT - Journal Article DEP - 20260102 PL - Ireland TA - Eur J Radiol JT - European journal of radiology JID - 8106411 RN - 0 (Protons) SB - IM MH - Humans MH - Female MH - Middle Aged MH - Adult MH - *Magnetic Resonance Imaging/methods MH - Reproducibility of Results MH - *Pancreas/diagnostic imaging MH - Male MH - Aged MH - *Adipose Tissue/diagnostic imaging MH - Breath Holding MH - Adolescent MH - Algorithms MH - Young Adult MH - Protons MH - Image Interpretation, Computer-Assisted/methods OTO - NOTNLM OT - Compressed sensing OT - Obesity OT - Pancreatic fat OT - magnetic resonance imaging (MRI) OT - nonalcoholic fatty pancreas disease (NAFPD) OT - proton density fat fraction (PDFF) COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: DK receives grant support from Philips Healthcare. HH is a member of the scientific advisory board of Oviva AG (Zurich, Switzerland) and CH of 4sigma GmbH (Oberhaching, Germany). HH and CH received speaker honoraria from Novo Nordisk (Copenhagen, Denmark). The other authors declare no conflicts of interest. EDAT- 2026/01/07 19:24 MHDA- 2026/01/24 06:36 CRDT- 2026/01/07 18:01 PHST- 2025/09/05 00:00 [received] PHST- 2025/12/17 00:00 [revised] PHST- 2025/12/31 00:00 [accepted] PHST- 2026/01/24 06:36 [medline] PHST- 2026/01/07 19:24 [pubmed] PHST- 2026/01/07 18:01 [entrez] AID - S0720-048X(25)00727-2 [pii] AID - 10.1016/j.ejrad.2025.112641 [doi] PST - ppublish SO - Eur J Radiol. 2026 Feb;195:112641. doi: 10.1016/j.ejrad.2025.112641. Epub 2026 Jan 2. PMID- 41499114 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260803 IS - 2574-3805 (Electronic) IS - 2574-3805 (Linking) VI - 9 IP - 1 DP - 2026 Jan 2 TI - Perceptions of GLP-1 RA Use for Children With Obesity Among Caregivers With Food Insecurity: A Qualitative Study. PG - e2552825 LID - 10.1001/jamanetworkopen.2025.52825 [doi] LID - e2552825 AB - IMPORTANCE: With the approval of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for pediatric obesity, families are increasingly considering pharmaceutical treatment alongside lifestyle optimization for their children, although how caregivers will make these decisions remains unexplored. This is especially important in contexts where food insecurity may limit the feasibility of lifestyle change and adjunct therapy could improve outcomes. OBJECTIVE: To explore how caregivers make decisions regarding the inclusion of GLP-1 RAs for pediatric obesity treatment in the context of food insecurity. DESIGN, SETTING, AND PARTICIPANTS: In this qualitative study, eligible participants were caregivers (aged >/=18 years) of children (aged <18 years) with obesity and metabolic dysfunction-associated steatotic liver disease who screened positive for moderate-severe food insecurity between July 1, 2022, and October 31, 2023. Caregivers were recruited from pediatric gastroenterology clinics of a regional academic health care system. Semistructured interviews via telephone or video were offered in participants' preferred language between December 1, 2023, and April 30, 2024. MAIN OUTCOMES AND MEASURES: The main outcome was factors influencing caregiver decisions regarding medication use for their child's metabolic disease. Interview transcripts were translated to English as needed, then thematically analyzed inductively by 2 research investigators to identify themes within an array of caregivers' decision-making processes. RESULTS: Of 37 eligible caregivers, 21 completed interviews, 20 of which were included in the analysis. Of the 20 caregiver participants (19 [95%] mothers; mean [SD] age, 40.5 [6.1] years), 18 (90%) were born outside the US, 13 (65%) had not completed high school, and 15 (75%) used a language other than English in clinical settings. Of the 20 child patients, 18 (90%) were male, and mean (SD) age at interview was 12.9 (2.9) years. All caregivers had received lifestyle-related recommendations from their child's physicians and had been referred to dietetics; 10 (50%) had met with a dietitian. Twelve (60%) desired adjunct pharmacotherapy for their child. Three common themes influenced caregiver decision-making about GLP-1 RA use: (1) prior experience with lifestyle change, (2) trust in the safety and efficacy of GLP-1 RAs, and (3) values regarding optimal care for children. An updated conceptual framework was applied to illustrate caregivers' decision-making. CONCLUSIONS AND RELEVANCE: In this qualitative study, children's caregivers experiencing food insecurity expressed interest in both lifestyle-only and medication-inclusive approaches, with decisions shaped by lived experience, perceptions of safety, and values. Shared decision-making conversations in clinical settings that acknowledge these influences-and address barriers to both treatment options-could foster more family-centered, equitable, and effective pediatric obesity care. FAU - Stephenson, Kathryn M AU - Stephenson KM AD - Division of Pediatric Gastroenterology & Hepatology, Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington. AD - Department of Subspecialty Pediatrics, Gastroenterology, Kaiser Permanente Medical Group, Oakland Medical Center, Oakland, California. FAU - Schwartz, Naomi R M AU - Schwartz NRM AD - Division of Pediatric Gastroenterology & Hepatology, Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington. FAU - Person, Hannibal AU - Person H AD - Division of Pediatric Gastroenterology & Hepatology, Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington. FAU - Blondet, Niviann AU - Blondet N AD - Division of Pediatric Gastroenterology & Hepatology, Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington. FAU - Benitez-Cortez, Maria E AU - Benitez-Cortez ME AD - Research Integration Hub, Seattle Children's Hospital, Seattle, Washington. FAU - Nuding, Mason AU - Nuding M AD - Division of Pediatric Gastroenterology & Hepatology, Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington. FAU - Kraft, Stephanie A AU - Kraft SA AD - Department of Bioethics and Decision Sciences, Geisinger College of Health Sciences, Danville, Pennsylvania. FAU - Suskind, David L AU - Suskind DL AD - Division of Pediatric Gastroenterology & Hepatology, Department of Pediatrics, Seattle Children's Hospital, Seattle, Washington. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260102 PL - United States TA - JAMA Netw Open JT - JAMA network open JID - 101729235 RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) SB - IM MH - Humans MH - Male MH - Female MH - *Caregivers/psychology MH - Qualitative Research MH - Child MH - *Glucagon-Like Peptide-1 Receptor Agonists MH - *Pediatric Obesity/drug therapy MH - *Food Insecurity MH - Adult MH - Adolescent MH - Middle Aged PMC - PMC12780928 COIS- Conflict of Interest Disclosures: Dr Suskind reported receiving personal fees from Abbott and Nestle HealthScience outside the submitted work. No other disclosures were reported. EDAT- 2026/01/07 13:17 MHDA- 2026/01/07 13:18 PMCR- 2026/01/07 CRDT- 2026/01/07 11:33 PHST- 2026/01/07 13:18 [medline] PHST- 2026/01/07 13:17 [pubmed] PHST- 2026/01/07 11:33 [entrez] PHST- 2026/01/07 00:00 [pmc-release] AID - 2843510 [pii] AID - zoi251407 [pii] AID - 10.1001/jamanetworkopen.2025.52825 [doi] PST - epublish SO - JAMA Netw Open. 2026 Jan 2;9(1):e2552825. doi: 10.1001/jamanetworkopen.2025.52825. PMID- 41498679 OWN - NLM STAT- MEDLINE DCOM- 20260625 LR - 20260625 IS - 1827-1928 (Electronic) IS - 0022-4707 (Linking) VI - 66 IP - 1 DP - 2026 Jan TI - Injury risk and workload analysis in elite adolescent female volleyball players using machine learning. PG - 72-81 LID - 10.23736/S0022-4707.25.16744-3 [doi] AB - BACKGROUND: This study investigates the key variables influencing injury occurrence in elite-level female volleyball players. It aims to evaluate three hypotheses: (1) the quantification of workload using the "System Training Response" score provides a superior explanation and prediction of injury occurrence compared to traditional methods such as sum or mean; (2) both menses and external workload serve as primary variables that explain injury occurrence; and (3) non-linear models yield better explanatory and predictive capabilities for injury occurrence than linear models. METHODS: Nineteen elite female volleyball players were monitored throughout a 190-day competitive season, during which various training-related parameters were collected. These parameters included internal and external workload quantification and menses data. To analyze and predict injury occurrence, machine learning techniques were employed, with a particular emphasis on Random Forest models. RESULTS: The Random Forest model demonstrated superior performance in describing injury occurrence, achieving an area under the receiver operating characteristic curve of 0.87. Key variables identified as significant contributors to injury occurrence included the players' age, menses status, and the percentage of intense jumps executed. Furthermore, the cross-validation procedure conducted on a reserved portion of the dataset yielded positive results, with an area under the receiver operating characteristic curve of 0.74, indicating a good generalization performance of the model. CONCLUSIONS: The findings of this study suggest that intense training prior to performance may increase the risk of injury, while older players appear to exhibit a lower risk of injury. These insights highlight the importance of tailored training strategies that consider both physiological factors and individual player profiles to mitigate injury risks in elite female volleyball athletes, including the presence or absence of menstruation with associated discomfort, which appears to be a relevant factor. FAU - Bouzigues, Theo AU - Bouzigues T AD - Ecole Normale Superieure de Rennes, Rennes, France - theobouzigues@orange.fr. AD - Movement, Sport and Health Laboratory (EA 1274), UFR APS, University of Rennes2, Rennes, France - theobouzigues@orange.fr. FAU - Candau, Robin AU - Candau R AD - INRAe Center de Montpellier, UMR 866 Dynamique Musculaire et Metabolisme Montpellier, France. FAU - Ayramo, Sami AU - Ayramo S AD - Faculty of Information Technology, University of Jyvaskyla, Jyvaskyla, Finland. FAU - Maurelli, Olivier AU - Maurelli O AD - INRAe Center de Montpellier, UMR 866 Dynamique Musculaire et Metabolisme Montpellier, France. AD - French Federation of Volleyball, Creteil, France. FAU - Prioux, Jacques AU - Prioux J AD - Ecole Normale Superieure de Rennes, Rennes, France. AD - Movement, Sport and Health Laboratory (EA 1274), UFR APS, University of Rennes2, Rennes, France. LA - eng PT - Journal Article PL - Italy TA - J Sports Med Phys Fitness JT - The Journal of sports medicine and physical fitness JID - 0376337 SB - IM MH - Humans MH - *Volleyball/injuries MH - Female MH - *Machine Learning MH - Adolescent MH - Random Forest MH - *Athletic Injuries/epidemiology MH - Predictive Learning Models MH - Risk Factors MH - Risk Assessment MH - Physical Conditioning, Human MH - Prediction Algorithms EDAT- 2026/01/07 13:17 MHDA- 2026/01/07 13:18 CRDT- 2026/01/07 10:16 PHST- 2026/01/07 13:18 [medline] PHST- 2026/01/07 13:17 [pubmed] PHST- 2026/01/07 10:16 [entrez] AID - S0022-4707.25.16744-3 [pii] AID - 10.23736/S0022-4707.25.16744-3 [doi] PST - ppublish SO - J Sports Med Phys Fitness. 2026 Jan;66(1):72-81. doi: 10.23736/S0022-4707.25.16744-3. PMID- 41497340 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260107 LR - 20260109 IS - 1178-2390 (Print) IS - 1178-2390 (Electronic) IS - 1178-2390 (Linking) VI - 18 DP - 2025 TI - Effectiveness of a Precede-Proceed Model-Based Health Promotion Intervention on Evaluating Changes In Mothers' Knowledge of Stunting Prevention in Indonesian Communities. PG - 8249-8256 LID - 10.2147/JMDH.S541443 [doi] AB - INTRODUCTION: Stunting remains a persistent public health challenge in Indonesia, with significant implications for children's long-term health and national development.The PRECEDE-PROCEED Model (PPM) offers a comprehensive framework for designing effective health education interventions, yet its application in community-based stunting prevention in Indonesia remains underexplored. PURPOSE: The purpose of this study was to identify and launch an increase in maternal knowledge before and after providing a health promotion intervention on stunting prevention. PATIENTS AND METHODS: The research method used was a pre-experimental study that used a one-group pre-test and post-test design involving 52 mothers of children under five years in Cimahi, West Java. A 20-item validated questionnaire was administered before and after a structured 90-minute health education session based on the PPM framework. Educational content focused on nutrition, hygiene, immunization, and child stimulation. RESULTS: Data were analyzed using the Wilcoxon Signed-Rank Test due to non-normal score distribution. Research results show participants' mean knowledge score increased significantly from 18.67 (SD = 1.79) to 19.69 (SD = 0.96) post-intervention (p = 0.00006). Most participants (73%) achieved a perfect score after the session, indicating a positive effect of the intervention. Reduced score variability suggests enhanced and more uniform knowledge dissemination. CONCLUSION: A health promotion intervention using the PRECEDE-PROCEED Model effectively improved maternal knowledge of stunting prevention. The participatory and contextualized approach demonstrated strong potential for replication in community health settings across Indonesia. Further studies should explore long-term behavioral outcomes and scalability. RESEARCH LIMITATIONS: Pre-experimental research design without a control group, so no comparison group that does not receive the intervention. The sample size is relatively small and limited to one location. Outcome measurement is only on short-term maternal knowledge. Focus only on maternal knowledge without measuring other aspects related to stunting prevention. CI - (c) 2025 Andriyani et al. FAU - Andriyani, Septian AU - Andriyani S AD - Doctoral Program in Medicine, Faculty of Medicine, Universitas Padjadjaran, Sumedang, West Java, Indonesia. AD - Department of Nursing, Faculty of Sport and Health Education, Universitas Pendidikan Indonesia, Bandung, West Java, Indonesia. FAU - Sulastri, Afianti AU - Sulastri A AD - Department of Nursing, Faculty of Sport and Health Education, Universitas Pendidikan Indonesia, Bandung, West Java, Indonesia. FAU - Fitriana, Lisna Anisa AU - Fitriana LA AD - Department of Nursing, Faculty of Sport and Health Education, Universitas Pendidikan Indonesia, Bandung, West Java, Indonesia. FAU - Darmawan, Dadang AU - Darmawan D AD - Stikes RS Dustira, Department of Nursing, Bandung, West Java, Indonesia. FAU - Perdani, Agni Laili AU - Perdani AL AUID- ORCID: 0000-0001-7105-1188 AD - Department of Nursing, Faculty of Sport and Health Education, Universitas Pendidikan Indonesia, Bandung, West Java, Indonesia. FAU - Safariah, Triana Dewi AU - Safariah TD AD - Stikes RS Dustira, Department of Nursing, Bandung, West Java, Indonesia. FAU - Malisa, Novi AU - Malisa N AD - Stikes RS Dustira, Department of Nursing, Bandung, West Java, Indonesia. FAU - Putri, Triyana Harlia AU - Putri TH AUID- ORCID: 0000-0002-2250-8089 AD - Department of Nursing, Universitas Tanjungpura, Pontianak, West Kalimantan, Indonesia. FAU - Mediani, Henny Suzana AU - Mediani HS AUID- ORCID: 0000-0001-6960-3692 AD - Department of Pediatric Nursing, Faculty of Nursing, Universitas Padjadjaran, Sumedang, West Java, Indonesia. LA - eng PT - Journal Article DEP - 20251226 PL - New Zealand TA - J Multidiscip Healthc JT - Journal of multidisciplinary healthcare JID - 101512691 PMC - PMC12765699 OTO - NOTNLM OT - health promotion OT - maternal knowledge OT - precede-proceed model OT - public health OT - stunting COIS- The authors report no conflicts of interest in this work. EDAT- 2026/01/07 06:30 MHDA- 2026/01/07 06:31 PMCR- 2025/12/26 CRDT- 2026/01/07 04:48 PHST- 2025/05/19 00:00 [received] PHST- 2025/12/16 00:00 [accepted] PHST- 2026/01/07 06:31 [medline] PHST- 2026/01/07 06:30 [pubmed] PHST- 2026/01/07 04:48 [entrez] PHST- 2025/12/26 00:00 [pmc-release] AID - 541443 [pii] AID - 10.2147/JMDH.S541443 [doi] PST - epublish SO - J Multidiscip Healthc. 2025 Dec 26;18:8249-8256. doi: 10.2147/JMDH.S541443. eCollection 2025. PMID- 41495137 OWN - NLM STAT- MEDLINE DCOM- 20260130 LR - 20260202 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2026 Jan 6 TI - Applicability and validation of Franco, Willems and Willems II dental age estimation models in a population of Ceara, Brazil. PG - 4129 LID - 10.1038/s41598-025-34218-6 [doi] LID - 4129 AB - Dental age assessment plays a crucial role in clinical and forensic contexts. For safer practices, however, the existing methods need to be tested. This study aimed to evaluate for the first time the applicability of Franco's, Willems', and Willems' II dental age assessment models in a Northeastern Brazilian sample. The sample consisted of 500 panoramic radiographs (250 males, 250 females) of Brazilian individuals between 6 and 15.9 years from the State of Ceara. Chronological (CA) and estimated (EA) ages compared using mean error (ME), mean absolute error (MAE), and root mean square error (RMSE). Statistical comparisons were performed through generalized estimating equations (GEE). The mean CA of the sample was 11.0 years. The mean EA was 11.3 years for Franco's model, 11.6 for Willems', and 11.5 for Willems II. Franco's model showed the smallest bias, with ME values being 0.25 and 0.21 years lower than Willems' and Willems II, respectively (p < 0.001). Differences between CA and EA were minimal across sexes and not clinically relevant. Age-group analysis revealed similar performance up to 11.9 years. Overall, Franco's model demonstrated better error metrics, but all the models showed comparable accuracy and consistency for dental age estimation in children and adolescents from Ceara, confirming their validity and suitability for both clinical and forensic applications in this population. CI - (c) 2026. The Author(s). FAU - Bezerra, Tacio Pinheiro AU - Bezerra TP AUID- ORCID: 0000-0002-1058-4172 AD - Forensic Dentistry, Ceara State Forensic Unit, Fortaleza, CE, Brazil. FAU - Goncalves, Raissa Araujo AU - Goncalves RA AUID- ORCID: 0009-0005-8575-7882 AD - Division of Forensic Dentistry and Anatomy, Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. FAU - Brito, Liz Magalhaes AU - Brito LM AUID- ORCID: 0009-0000-8296-306X AD - Division of Forensic Dentistry and Anatomy, Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. FAU - Moreira, Debora Duarte AU - Moreira DD AUID- ORCID: 0000-0002-2024-9976 AD - Division of Oral Radiology, Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. FAU - Angelakopoulos, Nikolaos AU - Angelakopoulos N AUID- ORCID: 0000-0001-8511-4645 AD - Division of Forensic Dentistry and Anatomy, Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. nikolaos.angelakopoulos@unibe.ch. AD - Department of Orthodontics and Dentofacial Orthopedics, University of Bern, Freiburgstrasse 7, 3010, Bern, Switzerland. nikolaos.angelakopoulos@unibe.ch. FAU - Napimoga, Marcelo AU - Napimoga M AUID- ORCID: 0000-0003-4472-365X AD - Division of Immunology, Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. FAU - Franco, Ademir AU - Franco A AUID- ORCID: 0000-0002-1417-2781 AD - Division of Forensic Dentistry and Anatomy, Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. AD - Department of Therapeutic Stomatology, Institute of Dentistry, Sechenov University, Moscow, Russia. LA - eng PT - Journal Article PT - Validation Study DEP - 20260106 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Male MH - Female MH - Adolescent MH - Brazil MH - Child MH - Radiography, Panoramic MH - *Tooth/diagnostic imaging PMC - PMC12858890 OTO - NOTNLM OT - Age OT - Forensic dentistry OT - Radiology OT - Teeth COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval: The outlined investigation protocol received approval from the Institutional Committee of Ethics in Human Research at the Faculdade Sao Leopoldo Mandic (protocol number: 92882425.2.0000.5374). The study was carried out following the ethical standards of the Declaration of Helsinki (Finland). Informed consent: The images utilized in this study constituted secondary data sourced from an established radiology database. Access to the data was authorized through informed permission granted by the database's legal custodian and subsequently approved by the relevant ethics committee. The ethical approval includes signed informed consent from the legal guardian(s) of all participants whose radiographs were used in this study. EDAT- 2026/01/07 01:11 MHDA- 2026/01/31 00:29 PMCR- 2026/01/06 CRDT- 2026/01/06 23:22 PHST- 2025/10/18 00:00 [received] PHST- 2025/12/26 00:00 [accepted] PHST- 2026/01/31 00:29 [medline] PHST- 2026/01/07 01:11 [pubmed] PHST- 2026/01/06 23:22 [entrez] PHST- 2026/01/06 00:00 [pmc-release] AID - 10.1038/s41598-025-34218-6 [pii] AID - 34218 [pii] AID - 10.1038/s41598-025-34218-6 [doi] PST - epublish SO - Sci Rep. 2026 Jan 6;16(1):4129. doi: 10.1038/s41598-025-34218-6. PMID- 41494878 OWN - NLM STAT- MEDLINE DCOM- 20260311 LR - 20260730 IS - 1590-3729 (Electronic) IS - 0939-4753 (Linking) VI - 36 IP - 4 DP - 2026 Apr TI - Diagnostic thresholds of cardiorespiratory fitness for identifying cardiometabolic risk in youth. PG - 104485 LID - S0939-4753(25)00640-4 [pii] LID - 10.1016/j.numecd.2025.104485 [doi] AB - BACKGROUND AND AIM: Cardiorespiratory fitness, measured as peak oxygen uptake (VO(2)peak), is a key marker of metabolic health in youth, but age- and sex-specific diagnostic thresholds for identifying elevated cardiometabolic risk (CMR) remain undefined. This study aimed to establish age- and sex-specific VO(2)peak cut-points for elevated CMR by (i) conducting a cross-sectional diagnostic analysis that compared the diagnostic accuracy of commonly used VO(2)peak estimation equations (Barnett, Leger, Matsuzaka) to select the best-performing index, and (ii) performing a systematic review and meta-analysis to synthesize and validate findings. METHODS AND RESULTS: To establish diagnostic thresholds of VO(2)peak for identifying CMR in youth, we conducted a two-part study. First, a cross-sectional analysis was performed using data from 1059 children aged 8-11 years. Second, a systematic review and meta-analysis were conducted to synthesize evidence from existing observational studies. The literature search included four databases. Eligible studies included cross-sectional or cohort designs with participants aged 3-18 years, and reported cardiorespiratory fitness as VO(2)peak along with composite measures of CMR. We included 14 studies comprising a total of 20,780 children and adolescents. Optimal VO(2)peak thresholds for identifying elevated CMR were 43.2 mL/kg/min for boys and 41.9 mL/kg/min for girls aged <13 years, and 40.0 mL/kg/min for boys and 38.5 mL/kg/min for girls aged >/=13. These thresholds demonstrated moderate-to-strong diagnostic performance, and corresponded to the 20th-40th percentiles of international normative data. CONCLUSION: We report novel age- and sex-specific VO(2)peak thresholds for elevated CMR in youth, with good diagnostic performance, to aid early identification and prevention. CI - Copyright (c) 2025 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Garcia-Hermoso, Antonio AU - Garcia-Hermoso A AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona, Spain. Electronic address: antonio.garciah@unavarra.es. FAU - Yanez-Sepulveda, Rodrigo AU - Yanez-Sepulveda R AD - Faculty of Education and Social Sciences, Universidad Andres Bello, Vina del Mar, Chile; School of Medicine, Universidad Espiritu Santo, Samborondon, Ecuador. FAU - Hormazabal-Aguayo, Ignacio AU - Hormazabal-Aguayo I AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona, Spain; Vicerrectoria de Investigacion y Postgrado, Universidad de La Serena, La Serena, Chile. FAU - Munoz-Pardeza, Jacinto AU - Munoz-Pardeza J AD - Navarrabiomed, Hospital Universitario de Navarra, Universidad Publica de Navarra (UPNA), IdiSNA, Pamplona, Spain. FAU - Hurtado-Almonacid, Juan AU - Hurtado-Almonacid J AD - eFidac grupo de de investigacion. Escuela de Educacion Fisica. Pontificia Universidad Catolica de Valparaiso, Chile. FAU - Ezzatvar, Yasmin AU - Ezzatvar Y AD - Lifestyle factors with impact on Ageing and overall Health (LAH) Research Group. Department of Nursing. University of Valencia, Valencia, Spain; Vicerrectoria de Investigacion y Postgrado, Universidad de Los Lagos, Osorno, Chile. FAU - Sanchez Lopez, Mairena AU - Sanchez Lopez M AD - Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain; Facultad de Educacion de Ciudad Real, Universidad de Castilla-La Mancha, Ciudad Real, Spain. FAU - Martinez-Vizcaino, Vicente AU - Martinez-Vizcaino V AD - Universidad de Castilla-La Mancha, Health and Social Research Center, Cuenca, Spain; Universidad Autonoma de Chile, Facultad de Ciencias de la Salud, Talca, Chile. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20251202 PL - Netherlands TA - Nutr Metab Cardiovasc Dis JT - Nutrition, metabolism, and cardiovascular diseases : NMCD JID - 9111474 SB - IM MH - Humans MH - *Cardiorespiratory Fitness MH - Male MH - Female MH - Child MH - Risk Assessment MH - Cross-Sectional Studies MH - Predictive Value of Tests MH - *Oxygen Consumption MH - Age Factors MH - Adolescent MH - Sex Factors MH - Reproducibility of Results MH - Cardiometabolic Risk Factors MH - *Exercise Test MH - *Cardiovascular Diseases/diagnosis/physiopathology/epidemiology MH - Prognosis OTO - NOTNLM OT - Aerobic fitness OT - Cardiometabolic health OT - Cut-offs OT - Peak oxygen uptake OT - Youth COIS- Declaration of competing interest The authors declare that they have no conflicts of interest relevant to the content of this study. EDAT- 2026/01/07 01:10 MHDA- 2026/03/12 01:09 CRDT- 2026/01/06 21:53 PHST- 2025/08/23 00:00 [received] PHST- 2025/10/30 00:00 [revised] PHST- 2025/11/28 00:00 [accepted] PHST- 2026/03/12 01:09 [medline] PHST- 2026/01/07 01:10 [pubmed] PHST- 2026/01/06 21:53 [entrez] AID - S0939-4753(25)00640-4 [pii] AID - 10.1016/j.numecd.2025.104485 [doi] PST - ppublish SO - Nutr Metab Cardiovasc Dis. 2026 Apr;36(4):104485. doi: 10.1016/j.numecd.2025.104485. Epub 2025 Dec 2. PMID- 41494680 OWN - NLM STAT- MEDLINE DCOM- 20260106 LR - 20260825 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Jan 6 TI - Assessing Associations Between Environmental, Sleep, and Physical Activity Factors and Metabolic Syndrome Risk: Protocol for the FEASible Study. PG - e82034 LID - 10.2196/82034 [doi] LID - e82034 AB - BACKGROUND: FEASible is a cross-sectional observational study that explores women's daily living patterns through wearable devices and home environment sensors to validate the use of physical activity and indoor air quality data as indicators of risk for metabolic syndrome (MetS) and cardiovascular disease. OBJECTIVE: Leveraging transdisciplinary expertise, we implement a low-cost, dense sampling approach among 800 adult women, 60% Hispanic or Latina, with a subgroup of 225 participants opting for neuroimaging to assess MetS-related brain vulnerability. METHODS: Participants residing in Central Texas use a smartwatch and a custom-built air quality sensor to monitor their activities and environment for two weeks. Other variables, such as social determinants of health, medical history, and lifestyle, are reported through surveys. During their initial visit, we gather blood pressure measurements, body composition, and lipid profile information. RESULTS: As of August 2025, a total of 805 participants have completed the eligibility survey, of whom 204 have completed 2 weeks of sensor data collection, showing a diverse participant pool comprising 60% (210/348) Hispanic or Latinas, 39% (135/348) non-Hispanic or Latinas, and 1% (3/348) unknown. Participants are aged 18-40 years, with an average age of 27 years (SD 6 years). The study was funded in May 2023 (National Heart, Lung, and Blood Institute; grant R01HL168374), and data collection began in October 2023, with a projected completion date of May 2028. Ongoing analyses and publication of early cohorts are expected to occur throughout 2026 and 2027, with final analyses and dissemination of results anticipated by the end of the funding period in 2028. CONCLUSIONS: We have established a feasible pipeline to collect data that will help yield valuable insights into MetS risk factors among Latina women, including brain scan magnetic resonance imaging data and environmental exposure measurements. This paper aims to provide a rationale for procedures and case examples from the first year of data collection leading to health risk modeling, thus informing future interventions on MetS, heart disease, and all-cause mortality among Latina women. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/82034. CI - (c)Tania Ramos-Santiago, Elise Huglo, Yanrong Li, Christian Corral, Congyu Wu, Kerry Kinney, Darla Castelli, Andreana Haley. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 06.01.2026. FAU - Ramos-Santiago, Tania AU - Ramos-Santiago T AUID- ORCID: 0009-0005-0770-7417 AD - Department of Psychology, University of Texas at Austin, Austin, TX, United States. FAU - Huglo, Elise AU - Huglo E AUID- ORCID: 0009-0000-7419-8054 AD - Maseeh Department of Civil, Architectural, and Environmental Engineering, University of Texas at Austin, Austin, TX, United States. FAU - Li, Yanrong AU - Li Y AUID- ORCID: 0009-0008-8118-0053 AD - Department of Psychology, University of Texas at Austin, Austin, TX, United States. FAU - Corral, Christian AU - Corral C AUID- ORCID: 0009-0000-5799-6417 AD - Department of Psychology, University of Texas at Austin, Austin, TX, United States. FAU - Wu, Congyu AU - Wu C AUID- ORCID: 0000-0002-6410-1375 AD - Department of Systems Science and Industrial Engineering, Binghamton University, Greater Binghamton, NY, United States. FAU - Kinney, Kerry AU - Kinney K AUID- ORCID: 0000-0003-1126-2172 AD - Maseeh Department of Civil, Architectural, and Environmental Engineering, University of Texas at Austin, Austin, TX, United States. FAU - Castelli, Darla AU - Castelli D AUID- ORCID: 0000-0002-8862-578X AD - Department of Physical Therapy, Movement, and Rehabilitation Sciences, Northeastern University, Boston, MA, United States. FAU - Haley, Andreana AU - Haley A AUID- ORCID: 0000-0003-1861-7861 AD - Department of Psychology, University of Texas at Austin, Austin, TX, United States. LA - eng GR - R01 HL168374/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20260106 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - *Metabolic Syndrome/epidemiology/etiology MH - Female MH - Adult MH - *Exercise/physiology MH - Cross-Sectional Studies MH - Feasibility Studies MH - *Sleep/physiology MH - Texas/epidemiology MH - Young Adult MH - Adolescent MH - Risk Factors MH - Wearable Electronic Devices PMC - PMC12820547 OTO - NOTNLM OT - Latina women's health OT - MetS OT - indoor air quality OT - metabolic health OT - metabolic syndrome OT - physical activity OT - wearable sensors COIS- Conflicts of Interest: None declared. EDAT- 2026/01/07 01:10 MHDA- 2026/01/07 01:11 PMCR- 2026/01/06 CRDT- 2026/01/06 19:53 PHST- 2025/08/07 00:00 [received] PHST- 2025/11/17 00:00 [accepted] PHST- 2025/11/13 00:00 [revised] PHST- 2026/01/07 01:11 [medline] PHST- 2026/01/07 01:10 [pubmed] PHST- 2026/01/06 19:53 [entrez] PHST- 2026/01/06 00:00 [pmc-release] AID - v15i1e82034 [pii] AID - 10.2196/82034 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Jan 6;15:e82034. doi: 10.2196/82034. PMID- 41494484 OWN - NLM STAT- MEDLINE DCOM- 20260124 LR - 20260124 IS - 1873-5347 (Electronic) IS - 0277-9536 (Linking) VI - 391 DP - 2026 Feb TI - Social capital and uptake of primary healthcare during protracted displacement: Evidence from four refugee settlements in northern Uganda. PG - 118846 LID - S0277-9536(25)01177-3 [pii] LID - 10.1016/j.socscimed.2025.118846 [doi] AB - The world's refugee populations primarily reside in low- and middle-income countries, where they face protracted displacement and limited financial and human capital. Social capital is among the few assets they can leverage for resilience. Despite its importance, few studies have examined how social capital influences the uptake of healthcare services during protracted displacement. This study examines the associations of refugee with access to maternal, newborn and child health (MNCH) services in northern Uganda's long-term settlements. We conducted cross-sectional probability household surveys across four refugee settlements with independent samples of caregivers of children 0-5, 12-23, and 0-59 months (n = 570). Caregivers' demographic characteristics and responses to 57 items from the Shortened Adapted Social Capital Assessment Tool were analyzed as independent variables. Dependent variables were MNCH service coverage and young child feeding practices. Factor analysis revealed three distinct social capital dimensions: Social Support (Omega = 0.73), Social Action (Omega = 0.72), and Community Cohesion (Omega = 0.48 indicating lower reliability). In adjusted multiple regression analyses, Social Support was positively associated with minimum dietary diversity (aOR = 1.35, 95 %CI = 1.04-1.74). Social Action was positively associated with antenatal care during the first trimester (aOR = 3.93, 95 %CI = 1.47-10.50), Tetanus Toxoid vaccination during pregnancy (aOR = 4.00, 95 %CI = 1.33-12.04) and postnatal care (aOR = 2.48, 95 %CI = 1.02-6.05). Community Cohesion showed positive associations with early initiation of breastfeeding (aOR = 3.47, 95 %CI = 1.00-12.06) and Vitamin A supplementation (aOR = 3.51, 95 %CI = 1.15-10.68). These findings suggest that social capital is linked to the uptake of essential MNCH services, with distinct dimensions showing positive associations with key health behaviors. Understanding these dynamics is important for designing effective, community-based health interventions in refugee settings. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Vollmer, Nancy AU - Vollmer N AD - Department of International Public Health, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. FAU - Anguyo, Robert AU - Anguyo R AD - Department of International Public Health, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. FAU - Sharma, Anjali AU - Sharma A AD - Centre for Infectious Disease Research in Zambia, Stand 378A / 15, Main Street, Ibex, Lusaka, Zambia. FAU - Valadez, Joseph J AU - Valadez JJ AD - Department of International Public Health, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool, L3 5QA, UK. Electronic address: Joseph.Valadez@Lstmed.ac.uk. LA - eng PT - Journal Article DEP - 20251130 PL - England TA - Soc Sci Med JT - Social science & medicine (1982) JID - 8303205 SB - IM MH - Humans MH - Uganda MH - *Refugees/statistics & numerical data/psychology MH - Female MH - *Social Capital MH - Cross-Sectional Studies MH - Male MH - Infant MH - Adult MH - Child, Preschool MH - Infant, Newborn MH - *Primary Health Care/statistics & numerical data MH - Surveys and Questionnaires MH - *Patient Acceptance of Health Care/statistics & numerical data/psychology MH - Middle Aged MH - Young Adult MH - Adolescent OTO - NOTNLM OT - Lot Quality Assurance Sampling (LQAS) OT - Maternal OT - Newborn and child health (MNCH) OT - Protracted displacement OT - Refugee health OT - Social capital OT - Social support OT - Uganda EDAT- 2026/01/07 01:11 MHDA- 2026/01/24 12:31 CRDT- 2026/01/06 18:07 PHST- 2025/06/04 00:00 [received] PHST- 2025/11/24 00:00 [revised] PHST- 2025/11/26 00:00 [accepted] PHST- 2026/01/24 12:31 [medline] PHST- 2026/01/07 01:11 [pubmed] PHST- 2026/01/06 18:07 [entrez] AID - S0277-9536(25)01177-3 [pii] AID - 10.1016/j.socscimed.2025.118846 [doi] PST - ppublish SO - Soc Sci Med. 2026 Feb;391:118846. doi: 10.1016/j.socscimed.2025.118846. Epub 2025 Nov 30. PMID- 41494358 OWN - NLM STAT- MEDLINE DCOM- 20260305 LR - 20260305 IS - 1096-7206 (Electronic) IS - 1096-7192 (Linking) VI - 147 IP - 3 DP - 2026 Mar TI - Influence of a 12 week at-home resistance exercise program on (13)C-glucose metabolism in patients with metabolic myopathies. PG - 109714 LID - S1096-7192(25)00706-1 [pii] LID - 10.1016/j.ymgme.2025.109714 [doi] AB - BACKGROUND: Metabolic myopathies (MM) are a diverse group of genetic disorders that impair cellular energy metabolism, resulting in exercise intolerance and fatigue. Previous studies have reported benefits of physiotherapy in patients with MM, however, objective assessments of their efficacy remain limited. The (13)C glucose breath test ((13)C-GBT) is a non-invasive measure of glucose metabolism through the detection of (13)CO(2) expelled from the tricarboxylic acid cycle. This study utilizes the in vivo(13)C-GBT assessment pre- and post-therapeutic intervention to evaluate the impact of a supervised 12 wk. at-home resistance training program on patients with MM. OBJECTIVES: The first experiment was to assess the repeatability of the in vivo(13)C-GBT through triplicate study days in healthy controls. The second experiment was to assess (13)C-glucose metabolism in participants with MM pre- and post-therapeutic intervention. DESIGN: Six healthy adult controls (3 F: 3 M) aged 22-29 y, and three adolescent participants (1 F: 2 M) aged 10-18 y with diagnosed MM were recruited. Participants completed up to three study days pre- and post-intervention, consuming a 1.5 mg/kg body weight dose of [U-(13)C(6)] d-glucose, and 1.5 g/kg body weight Trutol(R) glucose beverage. Breath samples collected during the 4 h study day were analyzed for (13)C enrichment with isotope ratio mass spectrometry, and used to calculate rate of glucose oxidation (mg/kg/min). Measured (13)C enrichment was used to calculate the rate of glucose oxidation (mg/kg/min) and interpreted with Area Under the Curve analysis, and determination of maximum rate (C(max)). RESULTS: Repeatability of the (13)C-GBT was confirmed in healthy participants, with average coefficients of variation (CV) being 8.9 % in males and 8.6 % in females at C(max). Among MM participants, exercise intervention increased glucose oxidation 23.5 % in subject MM-01 (F, 14 y), and 9 % in MM-02 (M, 16 y); but decreased -11.7 % in MM-04 (M, 17 y). All subjects showed a marginal increase in lean body mass (2-4 %). CONCLUSIONS: The non-invasive 4 h (13)C-GBT protocol shows potential as a feasible tool for clinicians to monitor glucose utilization due to its low patient burden and good repeatability. Future work should validate the repeatability of the assay in a larger patient population to confirm its translational potential to guide the management of MM patients. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Plant, Kendall AU - Plant K AD - BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, BC V5Z 4H4, Canada; Department of Pediatrics, The University of British Columbia, Vancouver, BC V6H 3V4, Canada. FAU - Howard, Caoimhe AU - Howard C AD - Division of Biochemical Genetics, BC Children's Hospital, Vancouver, BC V6H 3V4, Canada. FAU - Bourdon, Philippe AU - Bourdon P AD - Department of Kinesiology and Physical Education, McGill University, Montreal, QC H2W 1S4, Canada. FAU - Massarotto, Raffaele J AU - Massarotto RJ AD - Cardiovascular Physiology Laboratory, Faculty of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC V5A 1S6, Canada. FAU - Gamu, Daniel AU - Gamu D AD - BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, BC V5Z 4H4, Canada; School of Kinesiology, The University of British Columbia, BC V6T 1Z1, Canada. FAU - Gibson, William T AU - Gibson WT AD - BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, BC V5Z 4H4, Canada; Department of Medical Genetics, University of British Columbia, Vancouver, BC V6H 3N1, Canada. FAU - Stockler, Sylvia AU - Stockler S AD - BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, BC V5Z 4H4, Canada; Department of Pediatrics, The University of British Columbia, Vancouver, BC V6H 3V4, Canada; Division of Biochemical Genetics, BC Children's Hospital, Vancouver, BC V6H 3V4, Canada. FAU - Brunel-Guitton, Catherine AU - Brunel-Guitton C AD - BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, BC V5Z 4H4, Canada; Department of Pediatrics, The University of British Columbia, Vancouver, BC V6H 3V4, Canada; Division of Biochemical Genetics, BC Children's Hospital, Vancouver, BC V6H 3V4, Canada. FAU - Elango, Rajavel AU - Elango R AD - BC Children's Hospital Research Institute, BC Children's Hospital, Vancouver, BC V5Z 4H4, Canada; Department of Pediatrics, The University of British Columbia, Vancouver, BC V6H 3V4, Canada; School of Population and Public Health, The University of British Columbia, Vancouver, BC V6T 1Z3, Canada. Electronic address: relango@bcchr.ubc.ca. LA - eng PT - Journal Article DEP - 20251229 PL - United States TA - Mol Genet Metab JT - Molecular genetics and metabolism JID - 9805456 RN - IY9XDZ35W2 (Glucose) RN - 0 (Carbon Isotopes) RN - FDJ0A8596D (Carbon-13) SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Adolescent MH - *Glucose/metabolism MH - *Resistance Training/methods MH - Child MH - Carbon Isotopes/metabolism MH - Breath Tests/methods MH - Young Adult MH - *Muscular Diseases/metabolism/therapy MH - Energy Metabolism OTO - NOTNLM OT - (13)C-glucose OT - Breath test OT - Metabolic myopathy OT - Stable isotope OT - Trutol COIS- Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Rajavel Elango reports a relationship with Vitaflo USA LLC that includes: funding grants. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2026/01/07 01:10 MHDA- 2026/03/06 09:06 CRDT- 2026/01/06 18:04 PHST- 2025/10/17 00:00 [received] PHST- 2025/12/08 00:00 [revised] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/03/06 09:06 [medline] PHST- 2026/01/07 01:10 [pubmed] PHST- 2026/01/06 18:04 [entrez] AID - S1096-7192(25)00706-1 [pii] AID - 10.1016/j.ymgme.2025.109714 [doi] PST - ppublish SO - Mol Genet Metab. 2026 Mar;147(3):109714. doi: 10.1016/j.ymgme.2025.109714. Epub 2025 Dec 29. PMID- 41494029 OWN - NLM STAT- MEDLINE DCOM- 20260408 LR - 20260408 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 21 IP - 1 DP - 2026 TI - Performance of glomerular filtration rate equations using serum creatinine in children with congenital anomalies of the kidney and urinary tract. PG - e0340649 LID - 10.1371/journal.pone.0340649 [doi] LID - e0340649 AB - INTRODUCTION: Congenital anomalies of the kidney and urinary tract (CAKUT) are a significant cause of pediatric morbidity and mortality, often leading to chronic kidney disease (CKD). Accurate glomerular filtration rate (GFR) assessment is crucial for effective management, but a gold-standard pediatric GFR estimation formula remains elusive. This study compared the bedside Schwartz, Chronic Kidney Disease in Children (CKiD-U25) creatinine, and European Kidney Function Consortium (EKFC) creatinine-based equations against measured GFR (mGFR) using technetium-99m-diethylenetriaminepentaacetic acid (Tc-99mDTPA) clearance. METHODS: Data were collected from 276 children with CAKUT at Dr. Soetomo Academic General Hospital. Estimated GFR (eGFR) was calculated using the bedside Schwartz, CKiD-U25, and EKFC equations. mGFR was determined using Tc-99mDTPA clearance, considered the gold standard. Correlation (Spearman rs), bias, and accuracy (P30, percentage of eGFR within 30% of mGFR) were assessed. Subgroup analysis was performed for children older than two years. RESULTS: Both equations correlated significantly with mGFR (bedside Schwartz: r = 0.793; CKiD-U25: r = 0,793; EKFC: r = 0.745, p < 0.0001). However, the bedside Schwartz systematically underestimated mGFR (bias: -21.7 mL/min/1.73 m(2)), while the EKFC overestimated (bias: 17 mL/min/1.73 m(2), p < 0.0001). In children >2 years, correlations strengthened (bedside Schwartz: r = 0.804; EKFC: r = 0.835, p < 0.0001), with the EKFC demonstrating more accuracy (P30: 90.1%) compared to the bedside Schwartz CKiD-U25 creatinine (75% and 75%, respectively). CONCLUSION: These findings suggest the both bedside Schwartz and EKFC could be a reliable tool for GFR estimation in this pediatric CAKUT population. CI - Copyright: (c) 2026 Marpaung et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Marpaung, Ferdy Royland AU - Marpaung FR AD - Doctoral Program of Medical Science, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. FAU - Purnami, Santi Wulan AU - Purnami SW AD - Department of Statistics, Institut Teknologi Sepuluh Nopember, Surabaya, Indonesia. FAU - Andari, Shofi AU - Andari S AD - Department of Statistics, Institut Teknologi Sepuluh Nopember, Surabaya, Indonesia. FAU - Rohman, Ali AU - Rohman A AD - Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia. FAU - Notobroto, Hari Basuki AU - Notobroto HB AD - Faculty of Public Health, Universitas Airlangga, Surabaya Indonesia. FAU - Prasetyo, Risky Vitria AU - Prasetyo RV AUID- ORCID: 0000-0002-1708-5384 AD - Department of Child Health, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. FAU - Lumban Toruan, Anggia Augustasia AU - Lumban Toruan AA AD - Gotong Royong Hospital, Surabaya, Indonesia. FAU - Santoso, Djoko AU - Santoso D AD - Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. FAU - Aryati, Aryati AU - Aryati A AUID- ORCID: 0000-0002-9383-6354 AD - Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20260106 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - AYI8EX34EU (Creatinine) RN - VW78417PU1 (Technetium Tc 99m Pentetate) RN - Cakut SB - IM MH - *Glomerular Filtration Rate/physiology MH - Age Factors MH - *Creatinine/blood MH - *Urogenital Abnormalities/blood/diagnosis/physiopathology MH - *Vesico-Ureteral Reflux/blood/diagnosis/physiopathology MH - *Kidney Function Tests/methods/standards MH - Reproducibility of Results MH - *Renal Insufficiency, Chronic/blood/diagnosis/physiopathology MH - Retrospective Studies MH - Humans MH - Male MH - Female MH - Infant MH - Child, Preschool MH - Child MH - Technetium Tc 99m Pentetate/administration & dosage/pharmacokinetics MH - Renal Elimination PMC - PMC12774354 COIS- The authors have declared that no competing interests exist. EDAT- 2026/01/06 19:17 MHDA- 2026/01/06 19:18 PMCR- 2026/01/06 CRDT- 2026/01/06 14:23 PHST- 2025/07/04 00:00 [received] PHST- 2025/12/25 00:00 [accepted] PHST- 2026/01/06 19:18 [medline] PHST- 2026/01/06 19:17 [pubmed] PHST- 2026/01/06 14:23 [entrez] PHST- 2026/01/06 00:00 [pmc-release] AID - PONE-D-25-32018 [pii] AID - 10.1371/journal.pone.0340649 [doi] PST - epublish SO - PLoS One. 2026 Jan 6;21(1):e0340649. doi: 10.1371/journal.pone.0340649. eCollection 2026. PMID- 41493630 OWN - NLM STAT- MEDLINE DCOM- 20260106 LR - 20260204 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 1 DP - 2026 Jan 6 TI - Individualized online exercise therapy aids recovery in pediatric long-COVID-findings from an exploratory randomized controlled trial. PG - 54 LID - 10.1007/s00431-025-06705-5 [doi] LID - 54 AB - The purpose of this study is to evaluate the feasibility, safety, and effectiveness of an individualized online exercise therapy (IOET) designed to improve physical capacity and quality of life in children and adolescents with long-COVID. In a prospective, randomized, single-center exploratory trial, 14 patients aged 9-17 years with long-COVID (median symptom duration: 21 months) received either 6 or 12 weeks of IOET. Sessions were held twice weekly via telemedicine and individually adapted to physical ability and symptoms. Primary outcomes were functional performance (6-minute walk test [6MWT], sit-to-stand test [STST], and handgrip strength test [HST]). Secondary outcomes included school attendance, quality of life (PedsQL), safety, and self-reported recovery. All participants showed clinically improvements. In the 12-week IOET group, 6MWT increased from 396.0 to 616.3 m (+ 220.3 m, 95% CI 98.2-342.4), STST from 25.4 to 32.6 repetitions (+ 7.2, 1.9-12.5), and HST from 16.6 to 27.1 kg (+ 10.5 kg, 4.8-16.1). The 6-week group improved comparably (6MWT: 429.0 m to 601.6 m, (+ 172.6 m, 64.7-280.6); STST: 21.6 to 31.7 (+ 10.1, 3.1-17.1); HST: 17.3 to 22.1 kg (+ 4.8 kg (0.7-8.9)). School attendance rose from 58 to 97%, and PedsQL reflected improved quality of life and reduced fatigue. No adverse events or post-exertional symptom exacerbations occurred. Improvements persisted at the 3-month follow-up. CONCLUSIONS: IOET is feasible, safe, and associated with improved physical function, reintegration in everyday life, and its quality in pediatric long-COVID. These findings highlight IOET as a promising rehabilitation strategy and justify larger multicenter trials to confirm effectiveness and define optimal duration. WHAT IS KNOWN: * Children and adolescents with long-COVID often experience persistent fatigue, impaired physical capacity, and reduced quality of life, with limited evidence-based treatment options available. * Exercise therapy has shown beneficial effects in other chronic pediatric conditions such as cancer- or fatigue-related syndromes, improving strength, well-being, and social participation. WHAT IS NEW: * This exploratory randomized controlled trial demonstrates that individualized online exercise therapy is feasible, safe, and associated with clinically relevant improvements in physical function, quality of life, and school attendance in pediatric long-COVID, without negative side effects. * The findings highlight the potential of telemedicine-based rehabilitation strategies as accessible and effective treatment approaches for children and adolescents with post-infectious conditions such as long-COVID. CI - (c) 2026. The Author(s). FAU - Goretzki, Sarah Christina AU - Goretzki SC AD - Department of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147, Essen, Germany. sarah.goretzki@uk-essen.de. AD - West German Centre for Infectious Diseases (WZI), University Hospital Essen, University Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany. sarah.goretzki@uk-essen.de. FAU - Bergelt, Mara AU - Bergelt M AD - IST University of Applied Sciences, Health Management and Public Health, Dusseldorf, Germany. FAU - Weis, Laurent AU - Weis L AD - IST University of Applied Sciences, Health Management and Public Health, Dusseldorf, Germany. FAU - Hojeii, Rayan AU - Hojeii R AD - Department of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147, Essen, Germany. FAU - Gauss, Gabriele AU - Gauss G AD - Department of Pediatrics III, Pediatric Hematology and Oncology, Pulmonology and Sleep Medicine, Pediatric Rheumatology and Pediatric Cardiology, University Duisburg-Essen, Children's Hospital Essen, 45147, Essen, Germany. AD - West German Cancer Center (WTZ), University Hospital Essen, 45147, Essen, Germany. FAU - Gotte, Miriam AU - Gotte M AD - Department of Pediatrics III, Pediatric Hematology and Oncology, Pulmonology and Sleep Medicine, Pediatric Rheumatology and Pediatric Cardiology, University Duisburg-Essen, Children's Hospital Essen, 45147, Essen, Germany. AD - West German Cancer Center (WTZ), University Hospital Essen, 45147, Essen, Germany. FAU - Beller, Ronja AU - Beller R AD - Department of Pediatrics III, Pediatric Hematology and Oncology, Pulmonology and Sleep Medicine, Pediatric Rheumatology and Pediatric Cardiology, University Duisburg-Essen, Children's Hospital Essen, 45147, Essen, Germany. AD - West German Cancer Center (WTZ), University Hospital Essen, 45147, Essen, Germany. FAU - Benson, Sven AU - Benson S AD - Institute of Medical Psychology and Behavioral Immunobiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany. FAU - Schonecker, Anne AU - Schonecker A AD - Department of Pediatrics III, Pediatric Hematology and Oncology, Pulmonology and Sleep Medicine, Pediatric Rheumatology and Pediatric Cardiology, University Duisburg-Essen, Children's Hospital Essen, 45147, Essen, Germany. FAU - Marina, Adela Della AU - Marina AD AD - Department of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147, Essen, Germany. AD - Department of Pediatric Neurology, Centre for Neuromuscular Disorders, University Duisburg-Essen, Essen, Germany. FAU - Gangfuss, Andrea AU - Gangfuss A AD - Department of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147, Essen, Germany. AD - Department of Pediatric Neurology, Centre for Neuromuscular Disorders, University Duisburg-Essen, Essen, Germany. FAU - Stehling, Florian AU - Stehling F AD - Department of Pediatrics III, Pediatric Hematology and Oncology, Pulmonology and Sleep Medicine, Pediatric Rheumatology and Pediatric Cardiology, University Duisburg-Essen, Children's Hospital Essen, 45147, Essen, Germany. FAU - Pentek, Christina AU - Pentek C AD - Department of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147, Essen, Germany. AD - West German Centre for Infectious Diseases (WZI), University Hospital Essen, University Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany. FAU - von Loewenich, Anna AU - von Loewenich A AD - Department of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147, Essen, Germany. FAU - Huhne, Tom AU - Huhne T AD - Department of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147, Essen, Germany. FAU - Held, Clara AU - Held C AD - Department of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147, Essen, Germany. AD - West German Centre for Infectious Diseases (WZI), University Hospital Essen, University Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany. FAU - Voigt, Sebastian AU - Voigt S AD - Institute of Virology, University Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany. FAU - Felderhoff-Muser, Ursula AU - Felderhoff-Muser U AD - Department of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147, Essen, Germany. FAU - Schundeln, Michael M AU - Schundeln MM AD - Department of Pediatrics III, Pediatric Hematology and Oncology, Pulmonology and Sleep Medicine, Pediatric Rheumatology and Pediatric Cardiology, University Duisburg-Essen, Children's Hospital Essen, 45147, Essen, Germany. AD - West German Cancer Center (WTZ), University Hospital Essen, 45147, Essen, Germany. FAU - Bruns, Nora AU - Bruns N AD - Department of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147, Essen, Germany. FAU - Eckert, Katharina AU - Eckert K AD - IST University of Applied Sciences, Health Management and Public Health, Dusseldorf, Germany. FAU - Dohna-Schwake, Christian AU - Dohna-Schwake C AD - Department of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147, Essen, Germany. AD - West German Centre for Infectious Diseases (WZI), University Hospital Essen, University Duisburg-Essen, Hufelandstrasse 55, 45147, Essen, Germany. FAU - Brasseler, Maire AU - Brasseler M AD - Department of Pediatrics I, Neonatology, Pediatric Intensive Care, Pediatric Infectiology, Pediatric Neurology, University Duisburg-Essen, Children's Hospital Essen, 45147, Essen, Germany. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20260106 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Humans MH - Child MH - Adolescent MH - Female MH - Male MH - *COVID-19/rehabilitation MH - Quality of Life MH - *Exercise Therapy/methods MH - Prospective Studies MH - Treatment Outcome MH - SARS-CoV-2 MH - Feasibility Studies MH - Walk Test MH - Telemedicine PMC - PMC12774993 OTO - NOTNLM OT - Exercise therapy OT - Fatigue OT - Mental health OT - Pediatric long-COVID OT - Physical health OT - School participation COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2026/01/06 19:17 MHDA- 2026/01/06 19:18 PMCR- 2026/01/06 CRDT- 2026/01/06 13:08 PHST- 2025/09/06 00:00 [received] PHST- 2025/12/17 00:00 [accepted] PHST- 2025/12/11 00:00 [revised] PHST- 2026/01/06 19:18 [medline] PHST- 2026/01/06 19:17 [pubmed] PHST- 2026/01/06 13:08 [entrez] PHST- 2026/01/06 00:00 [pmc-release] AID - 10.1007/s00431-025-06705-5 [pii] AID - 6705 [pii] AID - 10.1007/s00431-025-06705-5 [doi] PST - epublish SO - Eur J Pediatr. 2026 Jan 6;185(1):54. doi: 10.1007/s00431-025-06705-5. PMID- 41493385 OWN - NLM STAT- MEDLINE DCOM- 20260614 LR - 20260817 IS - 1469-7610 (Electronic) IS - 0021-9630 (Linking) VI - 67 IP - 7 DP - 2026 Jul TI - Gut microbiome as a predictor for positive youth development transition from childhood to early adolescence: a cohort study. PG - 1015-1026 LID - 10.1111/jcpp.70109 [doi] AB - BACKGROUND: The gut microbiome is increasingly implicated in childhood mental health and may influence positive youth development (PYD). This study aims to characterize PYD transition patterns from childhood to adolescence and explore the predictive value of the gut microbiome. METHODS: This cohort study used two waves of data from the Chinese Adolescent Cohort study, including children aged 8-11 years at Wave 1, from Sichuan, Guizhou, and Chongqing provinces. PYD was assessed at both time points, and latent transition analysis identified changes over the 3-year follow-up period. Baseline stool samples were analyzed using 16 s rRNA sequencing. A light gradient boosting machine model was developed to link gut microbiota with PYD transition type in a training set (70%, n = 461), and validated with multinominal logistic analysis within a test set (30%, n = 200). Linear regression models were performed to assess dietary modifications on the gut microbiome. RESULTS: Three PYD transition profiles were identified: downgraded (declining to a lower pattern), promoted (advancing to a higher pattern), and stable development type (remaining in the same pattern). Fifteen microbial genera were identified as predictors of PYD transitions, and children with higher abundance of these taxa were more likely to transition to a stable or promoted profile rather than a downgraded profile (odds ratio ranging from 2.03 to 5.45). This predictive model demonstrated excellent performance, with an area under the curve of 0.91 (95% CI: 0.89, 0.93). The microbiome-PYD transition association was more pronounced in children in earlier stages of puberty. Furthermore, a diet high in fruits, vegetables, and soybeans was positively linked with PYD stable or promoted transition type. CONCLUSIONS: The gut microbiome presents predictive value in PYD transition from childhood to adolescence. Targeting these microbial taxa may inform future health promotion programs to optimize child development, particularly during the critical pubertal transition. CI - (c) 2026 Association for Child and Adolescent Mental Health. FAU - Xu, Yujie AU - Xu Y AUID- ORCID: 0000-0002-8941-2479 AD - Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Children's Medical Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Wang, Xiaoyu AU - Wang X AD - Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Children's Medical Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Chen, Mengxue AU - Chen M AD - Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Children's Medical Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, China. FAU - Xiong, Jingyuan AU - Xiong J AUID- ORCID: 0000-0001-9354-862X AD - Healthy Promotion and Food Nutrition & Safety Key Laboratory of Sichuan University, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China. FAU - Cheng, Guo AU - Cheng G AD - Laboratory of Molecular Translational Medicine, Center for Translational Medicine, Children's Medical Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Maternal & Child Nutrition Center, West China Second University Hospital, Sichuan University, Chengdu, China. LA - eng GR - 82304135/National Natural Science Foundation of China/ GR - U25A20154/National Natural Science Foundation of China/ GR - 2024NSFSC1806/the Department of Science and Technology of Sichuan Province/ GR - 2025ZNSFSC0641/the Department of Science and Technology of Sichuan Province/ GR - 2023M742451/the China Postdoctoral Science Foundation/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20260106 PL - England TA - J Child Psychol Psychiatry JT - Journal of child psychology and psychiatry, and allied disciplines JID - 0375361 SB - IM MH - Humans MH - Child MH - *Gastrointestinal Microbiome/physiology MH - Male MH - Female MH - *Adolescent Development/physiology MH - *Child Development/physiology MH - Adolescent MH - China MH - Cohort Studies OTO - NOTNLM OT - Gut microbiome OT - positive youth development OT - predictor OT - transition EDAT- 2026/01/06 19:17 MHDA- 2026/06/15 11:37 CRDT- 2026/01/06 12:52 PHST- 2025/12/01 00:00 [accepted] PHST- 2026/06/15 11:37 [medline] PHST- 2026/01/06 19:17 [pubmed] PHST- 2026/01/06 12:52 [entrez] AID - 10.1111/jcpp.70109 [doi] PST - ppublish SO - J Child Psychol Psychiatry. 2026 Jul;67(7):1015-1026. doi: 10.1111/jcpp.70109. Epub 2026 Jan 6. PMID- 41493180 OWN - NLM STAT- MEDLINE DCOM- 20260106 LR - 20260106 IS - 1607-8454 (Electronic) IS - 1024-5332 (Linking) VI - 31 IP - 1 DP - 2026 Dec TI - Serum gamma-glutamyl transpeptidase/albumin ratio in patients with acute myeloid leukemia: a new perspective on prognostic assessment. PG - 2611526 LID - 10.1080/16078454.2025.2611526 [doi] AB - OBJECTIVES: Evaluate the gamma-glutamyl transpeptidase-to-albumin ratio (GAR) as a prognostic biomarker in acute myeloid leukemia (AML). METHODS: We retrospectively analyzed the data of 162 patients with AML. Receiver operating characteristic (ROC) curve analysis determined the optimal cutoff value for GAR. Multivariate analysis was performed to assess the independent prognostic role of GAR for overall survival (OS) and event-free survival (EFS). Subgroup analysis was conducted to explore the impact of GAR in specific patient groups. RESULTS: ROC curve analysis showed an optimal cutoff value of 0.84 for GAR. Multivariate analysis revealed that GAR was an independent prognostic factor for OS and EFS. Subgroup analysis demonstrated that a high GAR was associated with shorter OS and EFS in patients with intermediate-risk stratification, those aged >/=60 years, or those that have not undergone hematopoietic stem cell transplantation. DISCUSSION: GAR reflects nutrition, inflammation, and oxidative stress. This study shows its potential to supplement existing AML risk stratification. Future prospective studies are needed to validate its clinical utility. CONCLUSION: We propose GAR as a prognostic biomarker in AML cases, providing a new perspective for prognostic assessment. FAU - Song, Min AU - Song M AD - Department of Hematology, Henan Provincial People's Clinical Medical School of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, People's Republic of China. FAU - Sun, Xiaoman AU - Sun X AD - Department of Hematology, People's Hospital of Henan University, Henan Provincial People's Hospital, Zhengzhou, People's Republic of China. FAU - Wang, Pengyu AU - Wang P AD - Department of Hematology, Henan Provincial People's Clinical Medical School of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, People's Republic of China. FAU - Liu, Ning AU - Liu N AD - Department of Hematology, Henan Provincial People's Clinical Medical School of Zhengzhou University, Henan Provincial People's Hospital, Zhengzhou, People's Republic of China. FAU - Wei, Menghao AU - Wei M AD - Department of Hematology, People's Hospital of Henan University, Henan Provincial People's Hospital, Zhengzhou, People's Republic of China. FAU - Shi, Jie AU - Shi J AD - Department of Hematology, Henan Provincial People's Clinical Medical School of Zhengzhou University, People's Hospital of Henan University, Henan Provincial People's Hospital, Zhengzhou, People's Republic of China. LA - eng PT - Journal Article DEP - 20260106 PL - England TA - Hematology JT - Hematology (Amsterdam, Netherlands) JID - 9708388 RN - EC 2.3.2.2 (gamma-Glutamyltransferase) RN - 0 (Serum Albumin) RN - 0 (Biomarkers, Tumor) SB - IM MH - Humans MH - *Leukemia, Myeloid, Acute/blood/mortality/diagnosis/therapy MH - *gamma-Glutamyltransferase/blood MH - Male MH - Female MH - Middle Aged MH - Prognosis MH - Adult MH - Aged MH - Retrospective Studies MH - *Serum Albumin/analysis/metabolism MH - Biomarkers, Tumor/blood MH - Young Adult MH - Adolescent MH - Aged, 80 and over OTO - NOTNLM OT - Acute myeloid leukemia OT - gamma-glutamyl transpeptidase to albumin ratio OT - prognosis EDAT- 2026/01/06 19:18 MHDA- 2026/01/06 19:19 CRDT- 2026/01/06 12:36 PHST- 2026/01/06 19:19 [medline] PHST- 2026/01/06 19:18 [pubmed] PHST- 2026/01/06 12:36 [entrez] AID - 10.1080/16078454.2025.2611526 [doi] PST - ppublish SO - Hematology. 2026 Dec;31(1):2611526. doi: 10.1080/16078454.2025.2611526. Epub 2026 Jan 6. PMID- 41493142 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20260307 IS - 1466-447X (Electronic) IS - 0264-0414 (Linking) VI - 44 IP - 7 DP - 2026 Apr TI - Smart swim goggles accurately measure heart rate during swim training: A criterion validation study. PG - 844-857 LID - 10.1080/02640414.2025.2610787 [doi] AB - Accurately measuring training intensity in swimming remains a challenge due to the limited availability of scientifically validated monitoring devices. The measurement of heart rate (HR), for example, would enable the calculation of HR-based training loads. The FORM Smart Swim 2 goggles measure HR via a temple-mounted optical sensor and enable real-time HR feedback. However, the goggles' HR measurement function has yet to be validated. Twenty-five experienced recreational swimmers simultaneously wore the goggles and a criterion chest-strap (Garmin HRM-Swim) during the completion of an assigned workout. Agreement was assessed at four levels of data aggregation: individual data points, intervals, main-sets, and whole-workouts. Respective mean HR (HR(mean)) from the goggles and criterion chest-strap were 136 +/- 17 bpm and 135 +/- 18 bpm (mean absolute percentage error = 1.0 +/- 1.2%). For HR(mean), concordance correlation was high (intervals: 0.91, 95%CI: 0.87 to 0.94; whole-workouts: 0.99, 95%CI: 0.99 to 1.0), and fixed bias was low (intervals: -0.23 bpm, 95%CI: -1.2 to 0.78 bpm; whole-workouts: -0.24 bpm; 95%CI: -0.94 to 0.46 bpm). Strong agreement was observed between the goggles and criterion chest-strap for HR measurements, particularly for HR(mean). Since HR(mean) serves as the primary input for HR-based training load metrics, the goggles provide valid data for monitoring swim training. FAU - Kits, Aidan AU - Kits A AD - Department of Biomedical Physiology and Kinesiology and Sports Analytics Group, Simon Fraser University Burnaby, BC, Canada. FAU - Chhatre Elder, Neha AU - Chhatre Elder N AD - Department of Biomedical Physiology and Kinesiology and Sports Analytics Group, Simon Fraser University Burnaby, BC, Canada. FAU - Eisenhardt, Dan AU - Eisenhardt D AD - FORM Athletica Inc, Vancouver, BC, Canada. AD - Department of Health Science and Technology, ExerciseTech, Aalborg University Gistrup, Denmark. FAU - Daryoush Hamedani, Yasmin AU - Daryoush Hamedani Y AD - Department of Biomedical Physiology and Kinesiology and Sports Analytics Group, Simon Fraser University Burnaby, BC, Canada. FAU - Hoskinson, Reynald AU - Hoskinson R AD - FORM Athletica Inc, Vancouver, BC, Canada. FAU - Madeleine, Pascal AU - Madeleine P AD - Department of Health Science and Technology, ExerciseTech, Aalborg University Gistrup, Denmark. FAU - Samani, Afshin AU - Samani A AD - Department of Health Science and Technology, ExerciseTech, Aalborg University Gistrup, Denmark. FAU - Kristiansen, Mathias AU - Kristiansen M AD - Department of Health Science and Technology, ExerciseTech, Aalborg University Gistrup, Denmark. FAU - Clarke, David C AU - Clarke DC AUID- ORCID: 0000-0002-1520-5426 AD - Department of Biomedical Physiology and Kinesiology and Sports Analytics Group, Simon Fraser University Burnaby, BC, Canada. LA - eng PT - Journal Article PT - Validation Study DEP - 20260106 PL - England TA - J Sports Sci JT - Journal of sports sciences JID - 8405364 SB - IM MH - Humans MH - *Swimming/physiology MH - *Heart Rate/physiology MH - Male MH - Female MH - Young Adult MH - *Physical Conditioning, Human MH - Adult MH - Adolescent MH - *Fitness Trackers MH - Wearable Electronic Devices MH - Reproducibility of Results OTO - NOTNLM OT - Photoplethysmography OT - fitness trackers OT - swimming OT - training load OT - validation study EDAT- 2026/01/06 19:17 MHDA- 2026/03/07 18:37 CRDT- 2026/01/06 12:33 PHST- 2026/03/07 18:37 [medline] PHST- 2026/01/06 19:17 [pubmed] PHST- 2026/01/06 12:33 [entrez] AID - 10.1080/02640414.2025.2610787 [doi] PST - ppublish SO - J Sports Sci. 2026 Apr;44(7):844-857. doi: 10.1080/02640414.2025.2610787. Epub 2026 Jan 6. PMID- 41493139 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260114 LR - 20260216 IS - 2049-3614 (Print) IS - 2049-3614 (Electronic) IS - 2049-3614 (Linking) VI - 15 IP - 1 DP - 2026 Jan 1 TI - Continuous subcutaneous hydrocortisone infusion in pediatric primary adrenal insufficiency: a cohort study. LID - e250696 [pii] LID - 10.1530/EC-25-0696 [doi] AB - OBJECTIVE: Primary adrenal insufficiency (PAI) in children, most commonly caused by congenital adrenal hyperplasia (CAH), is challenging to treat due to the short half-life of hydrocortisone and the difficulty in mimicking the physiological rhythm of cortisol. Continuous subcutaneous hydrocortisone infusion (CSHI) has shown benefits in CAH adults but remains poorly studied in children. The aim of our study was to evaluate the feasibility, safety, and clinical efficacy of CSHI in pediatric patients under oral treatment with poorly controlled PAI. METHODS: We conducted a retrospective monocentric study including 13 children and adolescents with PAI who were switched from oral hydrocortisone to CSHI between 2017 and 2024 due to a lack of disease control. Hormonal and clinical parameters were monitored over a median follow-up of 48 months. RESULTS: The median age at CSHI initiation was 11.08 (7.75-14.08) years. Eleven patients (84.6%) had CAH. The median duration of CSHI was 48 (6-54) months. Biochemical control improved, morning cortisol increased, while ACTH, 17-OHP, androstenedione, and testosterone levels decreased during follow-up. Growth velocity and BMI remained stable. In one patient with prior and recurrent adrenal crises, these events ceased. In boys with testicular adrenal rest tumors, tumor volume decreased or resolved. One adolescent girl with amenorrhea resumed regular menstrual cycles under CSHI. CSHI was well tolerated with no major complications. CONCLUSION: CSHI offers a promising therapeutic alternative for children with PAI who are poorly controlled on oral therapy. It provides more physiological cortisol delivery, improves hormonal control, and appears safe during long-term pediatric use. Larger prospective studies are needed to confirm these findings and evaluate quality-of-life outcomes. FAU - Fouatih, Khadidja AU - Fouatih K AUID- ORCID: 0009-0009-8794-4138 AD - AP-HP, Universite Paris-Saclay, Service Endocrinologie et diabete de l'enfant, Centre de Reference des Maladies Rares du Developpement Genital (CRMR DEVGEN), Hopital Bicetre Paris-Saclay, Le Kremlin-Bicetre, France. FAU - Trouvin, Marie-Agathe AU - Trouvin MA AD - AP-HP, Universite Paris-Saclay, Service Endocrinologie et diabete de l'enfant, Centre de Reference des Maladies Rares du Developpement Genital (CRMR DEVGEN), Hopital Bicetre Paris-Saclay, Le Kremlin-Bicetre, France. FAU - Lambert, Anne-Sophie AU - Lambert AS AUID- ORCID: 0000-0002-4232-3882 AD - AP-HP, Universite Paris-Saclay, Service Endocrinologie et diabete de l'enfant, Centre de Reference des Maladies Rares du Developpement Genital (CRMR DEVGEN), Hopital Bicetre Paris-Saclay, Le Kremlin-Bicetre, France. AD - INSERM, UMR-S U1185, Physiologie et Physiopathologie Endocriniennes, Le Kremlin Bicetre, France. FAU - Rothenbuhler, Anya AU - Rothenbuhler A AD - AP-HP, Universite Paris-Saclay, Service Endocrinologie et diabete de l'enfant, Centre de Reference des Maladies Rares du Developpement Genital (CRMR DEVGEN), Hopital Bicetre Paris-Saclay, Le Kremlin-Bicetre, France. FAU - Verdelet, Tristan AU - Verdelet T AD - AP-HP, Universite Paris-Saclay, Service Endocrinologie et diabete de l'enfant, Centre de Reference des Maladies Rares du Developpement Genital (CRMR DEVGEN), Hopital Bicetre Paris-Saclay, Le Kremlin-Bicetre, France. FAU - Lecoq, Anne-Lise AU - Lecoq AL AD - INSERM, UMR-S U1185, Physiologie et Physiopathologie Endocriniennes, Le Kremlin Bicetre, France. AD - AP-HP, Universite Paris-Saclay, Centre de Recherche Clinique Paris-Saclay, Hopital Bicetre Paris-Saclay, Le Kremlin Bicetre, France. AD - AP-HP, Universite Paris-Saclay, Service d'Endocrinologie et des Maladies de la Reproduction, Hopital Bicetre Paris-Saclay, Le Kremlin-Bicetre, France. FAU - Bouligand, Jerome AU - Bouligand J AD - INSERM, UMR-S U1185, Physiologie et Physiopathologie Endocriniennes, Le Kremlin Bicetre, France. AD - AP-HP, Universite Paris-Saclay, Service de Medecine Genomique et Pharmacogenomique, Hopital Bicetre Paris-Saclay, Le Kremlin Bicetre, France. FAU - Laddada, Lilia AU - Laddada L AD - AP-HP, Universite Paris-Saclay, Service de Medecine Genomique et Pharmacogenomique, Hopital Bicetre Paris-Saclay, Le Kremlin Bicetre, France. FAU - Chappell, Kenneth AU - Chappell K AD - INSERM, UMR-S U1185, Physiologie et Physiopathologie Endocriniennes, Le Kremlin Bicetre, France. AD - AP-HP, Universite Paris-Saclay, Service de Medecine Genomique et Pharmacogenomique, Hopital Bicetre Paris-Saclay, Le Kremlin Bicetre, France. FAU - Lopez, Maureen AU - Lopez M AD - AP-HP, Universite Paris-Saclay, Service de Medecine Genomique et Pharmacogenomique, Hopital Bicetre Paris-Saclay, Le Kremlin Bicetre, France. FAU - Bouyacoub, Mohammed AU - Bouyacoub M AD - AP-HP, Universite Paris-Saclay, Service de Biochimie, Hormonologie, Pharmaco-Toxicologie, UF Hormonologie, Hopital Bicetre Paris-Saclay, Le Kremlin Bicetre, France. FAU - Yahia, Azza AU - Yahia A AD - AP-HP, Universite Paris-Saclay, Service de Biochimie, Hormonologie, Pharmaco-Toxicologie, UF Hormonologie, Hopital Bicetre Paris-Saclay, Le Kremlin Bicetre, France. FAU - Haidar, Hazar AU - Haidar H AD - AP-HP, Universite Paris-Saclay, Service de Biochimie, Hormonologie, Pharmaco-Toxicologie, UF Hormonologie, Hopital Bicetre Paris-Saclay, Le Kremlin Bicetre, France. FAU - Trabado, Severine AU - Trabado S AD - INSERM, UMR-S U1185, Physiologie et Physiopathologie Endocriniennes, Le Kremlin Bicetre, France. AD - AP-HP, Universite Paris-Saclay, Service de Biochimie, Hormonologie, Pharmaco-Toxicologie, UF Hormonologie, Hopital Bicetre Paris-Saclay, Le Kremlin Bicetre, France. FAU - Linglart, Agnes AU - Linglart A AD - AP-HP, Universite Paris-Saclay, Service Endocrinologie et diabete de l'enfant, Centre de Reference des Maladies Rares du Developpement Genital (CRMR DEVGEN), Hopital Bicetre Paris-Saclay, Le Kremlin-Bicetre, France. AD - INSERM, UMR-S U1185, Physiologie et Physiopathologie Endocriniennes, Le Kremlin Bicetre, France. FAU - Bouvattier, Claire AU - Bouvattier C AD - AP-HP, Universite Paris-Saclay, Service Endocrinologie et diabete de l'enfant, Centre de Reference des Maladies Rares du Developpement Genital (CRMR DEVGEN), Hopital Bicetre Paris-Saclay, Le Kremlin-Bicetre, France. AD - INSERM, UMR-S U1185, Physiologie et Physiopathologie Endocriniennes, Le Kremlin Bicetre, France. FAU - Ait Tayeb, Abd El Kader AU - Ait Tayeb AEK AUID- ORCID: 0000-0001-6432-1098 AD - INSERM, UMR-S U1185, Physiologie et Physiopathologie Endocriniennes, Le Kremlin Bicetre, France. AD - AP-HP, Universite Paris-Saclay, Centre de Recherche Clinique Paris-Saclay, Hopital Bicetre Paris-Saclay, Le Kremlin Bicetre, France. AD - AP-HP, Universite Paris-Saclay, Service de Medecine Genomique et Pharmacogenomique, Hopital Bicetre Paris-Saclay, Le Kremlin Bicetre, France. LA - eng PT - Journal Article DEP - 20260114 PL - England TA - Endocr Connect JT - Endocrine connections JID - 101598413 PMC - PMC12811715 OTO - NOTNLM OT - congenital adrenal hyperplasia OT - continuous subcutaneous hydrocortisone infusion OT - primary adrenal insufficiency COIS- Khadidja Fouatih, Marie-Agathe Trouvin, Anne-Sophie Lambert, Anya Rothenbuhler, Tristan Verdelet, Anne-Lise Lecoq, Jerome Bouligand, Lilia Laddada, Kenneth Chappell, Maureen Lopez, Mohammed Bouyacoub, Azza Yahia, Hazar Haidar, Severine Trabado, Agnes Linglart, Claire Bouvattier, and Abd El Kader Ait Tayeb declare that they have no competing interests. EDAT- 2026/01/06 19:17 MHDA- 2026/01/06 19:18 PMCR- 2026/01/14 CRDT- 2026/01/06 12:32 PHST- 2025/10/15 00:00 [received] PHST- 2026/01/05 00:00 [accepted] PHST- 2026/01/06 19:18 [medline] PHST- 2026/01/06 19:17 [pubmed] PHST- 2026/01/06 12:32 [entrez] PHST- 2026/01/14 00:00 [pmc-release] AID - e250696 [pii] AID - EC-25-0696 [pii] AID - 10.1530/EC-25-0696 [doi] PST - epublish SO - Endocr Connect. 2026 Jan 14;15(1):e250696. doi: 10.1530/EC-25-0696. Print 2026 Jan 1. PMID- 41493094 OWN - NLM STAT- MEDLINE DCOM- 20260312 LR - 20260312 IS - 1525-6073 (Electronic) IS - 0742-0528 (Linking) VI - 43 IP - 4 DP - 2026 Apr TI - Daytime eating habits and their association with anemia status among Malaysian female university students. PG - 519-528 LID - 10.1080/07420528.2025.2611856 [doi] AB - Anemia remains a significant public health concern, especially among young women. The SCARF (Study to Combat Anemia-Research for Female Students) study examined the association between daytime eating habits and anemia among Malaysian female university students. Using a validated chrono-nutrition questionnaire, meal patterns, dietary habits, and meal regularity were analyzed, while anemia status was determined by hemoglobin levels. Among 674 students, there were 44.4% Malay, 48.8% Chinese, and 3.4% Indian, with a mean age of 21.2 +/- 1.5 y. About 59.3% were anemic, with a mean hemoglobin level of 11.6 +/- 1.3 g/dL. Daytime meal-skipping habits were linked to significantly lower energy (p < 0.038), fat (p < 0.017), and folate intake (p = 0.003). Breakfast skipping was prevalent among anemic students (70%) compared to non-anemic students (61.3%; chi(2) = 5.51, p = 0.019). Irregular breakfast habits significantly increased anemia prevalence (79.8% vs. 20.3%; chi(2) = 5.10, p = 0.024). Lunch skipping three or more times weekly was a significant predictor of anemia, with an odds ratio of 1.62 (95% CI: 1.01-2.43; p = 0.04). These findings underscore the need for university health initiatives to promote regular breakfast and lunch habits, mitigating anemia risks and fostering long-term student health. FAU - Mok, Kai Ting AU - Mok KT AUID- ORCID: 0000-0002-7880-9235 AD - Department of Food Science and Nutrition, UCSI University, Kuala Lumpur, Malaysia. FAU - Kaur, Satvinder AU - Kaur S AUID- ORCID: 0000-0003-0808-9612 AD - Department of Food Science and Nutrition, UCSI University, Kuala Lumpur, Malaysia. FAU - Say, Yee-How AU - Say YH AUID- ORCID: 0000-0002-8554-049X AD - Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Petaling Jaya, Malaysia. FAU - Buhari, Siti Sabariah AU - Buhari SS AUID- ORCID: 0000-0003-3021-4635 AD - Center for Dietetics Studies, Faculty of Health Sciences, Universiti Teknologi MARA, Puncak Alam, Malaysia. FAU - Sivapathy, Shashikala AU - Sivapathy S AD - Department of Food Science and Nutrition, UCSI University, Kuala Lumpur, Malaysia. FAU - Pot, Gerda K AU - Pot GK AUID- ORCID: 0000-0002-0863-4484 AD - Department of Nutritional Sciences, King's College London, London, UK. LA - eng PT - Journal Article DEP - 20260106 PL - England TA - Chronobiol Int JT - Chronobiology international JID - 8501362 RN - 0 (Hemoglobins) SB - IM MH - Humans MH - Female MH - *Feeding Behavior/physiology MH - Malaysia/epidemiology MH - *Students MH - Universities MH - Young Adult MH - *Anemia/epidemiology/physiopathology MH - Adult MH - *Circadian Rhythm/physiology MH - Prevalence MH - Surveys and Questionnaires MH - Cross-Sectional Studies MH - Hemoglobins/metabolism MH - Adolescent MH - Breakfast OTO - NOTNLM OT - Anemia OT - chrono-nutrition OT - daytime eating habits OT - meal skipping OT - young women EDAT- 2026/01/06 19:17 MHDA- 2026/03/12 07:04 CRDT- 2026/01/06 12:29 PHST- 2026/03/12 07:04 [medline] PHST- 2026/01/06 19:17 [pubmed] PHST- 2026/01/06 12:29 [entrez] AID - 10.1080/07420528.2025.2611856 [doi] PST - ppublish SO - Chronobiol Int. 2026 Apr;43(4):519-528. doi: 10.1080/07420528.2025.2611856. Epub 2026 Jan 6. PMID- 41492713 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20260307 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) VI - 82 IP - 3 DP - 2026 Mar TI - Feasibility and safety of a modified volume-based feeding protocol in critically ill children: A pilot study. PG - 812-818 LID - 10.1002/jpn3.70335 [doi] AB - OBJECTIVES: Enteral nutrition interruptions (ENIs) are common in critically ill children and may cause underfeeding. Volume-based feeding practices (VBFPs) mitigate ENIs, but their use has not been reported in pediatric critical care. We analyzed whether a modified VBFP (MVBFP), based on compensatory feeding over the subsequent 24 h, is feasible and safe. METHODS: Prospective longitudinal study of critically ill children aged 1 month-18 years receiving enteral nutrition in whom an MVBFP was applied. Compensatory increased enteral feeding goal rates (CIEFGR) were defined as instances in which the volume lost due to an ENI was replaced gradually over the subsequent 24 h by increasing the infusion rate. Data included demographics, ENI characteristics, volume and rate during compensatory feeding, caloric and protein intake, and gastrointestinal or metabolic adverse effects. We also recorded pre-existing gastrointestinal conditions and formula type. RESULTS: Twenty-eight CIEFGR were recorded in 21 children. The median compensatory period was 24 h (interquartile range [IQR]: 17.5-24), with a median additional volume of 20 mL/kg (IQR: 10.5-33.1), corresponding to increases of 18.8 kcal/kg (IQR: 9.8-27.8) and 0.5 g/kg protein (IQR: 0.23-0.8). The infusion rate rose from 21 to 27 mL/h (IQR: 20-33). Gastrointestinal signs (increased gastric residual volume, abdominal distension, nausea) occurred in 10.7% of episodes, were mild, and required no intervention. No significant metabolic alterations were observed. CONCLUSIONS: An MVBFP using compensatory feeding in critically ill children appears feasible and safe, improving caloric and protein delivery without increasing gastrointestinal side effects. CI - (c) 2026 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Solana Garcia, Maria Jose AU - Solana Garcia MJ AUID- ORCID: 0000-0001-6083-2528 AD - Pediatric Intensive Care Unit, Hospital General Universitario Gregorio Maranon, Madrid, Spain. AD - Department of Public and Maternal-Child Health, Universidad Complutense, Madrid, Spain. AD - Health Research Institute of the Gregorio Maranon Hospital, Madrid, Spain. AD - Mother and Child Health and Development Network (REDSAMID), ISCIII Subdirectorate General for Research Assessment and Promotion and the ERDF (RD16/0022), Madrid, Spain. FAU - Lopez Gonzalez, Jorge AU - Lopez Gonzalez J AD - Pediatric Intensive Care Unit, Hospital General Universitario Gregorio Maranon, Madrid, Spain. AD - Health Research Institute of the Gregorio Maranon Hospital, Madrid, Spain. AD - Mother and Child Health and Development Network (REDSAMID), ISCIII Subdirectorate General for Research Assessment and Promotion and the ERDF (RD16/0022), Madrid, Spain. FAU - Manrique Martin, Gema AU - Manrique Martin G AD - Pediatric Intensive Care Unit, Hospital General Universitario Gregorio Maranon, Madrid, Spain. AD - Health Research Institute of the Gregorio Maranon Hospital, Madrid, Spain. AD - Mother and Child Health and Development Network (REDSAMID), ISCIII Subdirectorate General for Research Assessment and Promotion and the ERDF (RD16/0022), Madrid, Spain. FAU - Lopez-Herce Cid, Jesus AU - Lopez-Herce Cid J AD - Pediatric Intensive Care Unit, Hospital General Universitario Gregorio Maranon, Madrid, Spain. AD - Department of Public and Maternal-Child Health, Universidad Complutense, Madrid, Spain. AD - Health Research Institute of the Gregorio Maranon Hospital, Madrid, Spain. AD - Mother and Child Health and Development Network (REDSAMID), ISCIII Subdirectorate General for Research Assessment and Promotion and the ERDF (RD16/0022), Madrid, Spain. LA - eng GR - None/ PT - Journal Article DEP - 20260105 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM MH - Humans MH - *Enteral Nutrition/methods/adverse effects MH - *Critical Illness/therapy MH - Infant MH - Child, Preschool MH - Child MH - Pilot Projects MH - Male MH - Feasibility Studies MH - Female MH - Prospective Studies MH - Adolescent MH - Longitudinal Studies MH - *Critical Care/methods MH - Energy Intake OTO - NOTNLM OT - critical care OT - enteral nutrition interruptions OT - nutrition OT - pediatric critical care EDAT- 2026/01/06 19:17 MHDA- 2026/03/07 18:37 CRDT- 2026/01/06 12:02 PHST- 2025/10/28 00:00 [revised] PHST- 2025/07/02 00:00 [received] PHST- 2025/11/05 00:00 [accepted] PHST- 2026/03/07 18:37 [medline] PHST- 2026/01/06 19:17 [pubmed] PHST- 2026/01/06 12:02 [entrez] AID - 10.1002/jpn3.70335 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Mar;82(3):812-818. doi: 10.1002/jpn3.70335. Epub 2026 Jan 5. PMID- 41491484 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260813 IS - 1471-2474 (Electronic) IS - 1471-2474 (Linking) VI - 27 IP - 1 DP - 2026 Jan 5 TI - PD-L1 mRNA expression correlates with tumor growth rate in giant cell tumor of bone: a volumetric MRI analysis. LID - 10.1186/s12891-025-09468-0 [doi] LID - 178 AB - BACKGROUND: Giant cell tumor of bone (GCTB) is a locally aggressive neoplasm with variable biological behavior. Programmed death-ligand 1 (PD-L1) has been implicated in tumor progression across multiple malignancies, but its relationship to growth kinetics in GCTB remains unclear. This study investigated whether PD-L1 mRNA expression correlates with tumor growth rate in extremity GCTB. METHODS: This single-institution retrospective cohort study included 36 patients with GCTB treated surgically between January 2020 and December 2024. Of these, 18 provided consent for research use of tissue; four were excluded due to lack of serial MRI data, yielding a final cohort of 14 patients. PD-L1 mRNA levels were quantified using real-time PCR. Tumor volumes were segmented from MRI using 3D Slicer, and growth rate (cc/month) was calculated. Patients were stratified into high- and low-PD-L1 groups using the cohort median fold change (2.62) as an exploratory cutoff. Group comparisons used Mann-Whitney U and Fisher's exact tests, and Spearman's rank correlation analysis was performed to assess the relationship between continuous PD-L1 expression and tumor growth rate. Exploratory linear regressions were performed adjusting for age, sex, tumor site, and preoperative denosumab use. RESULTS: Median age was 32 years; 57% were male. Tumors with high PD-L1 expression showed faster growth than those with low expression (5.0 [1.3-7.1] vs. 0.8 [0.2-2.1] cc/month; p = 0.038). This relationship was further supported by a significant positive correlation between PD-L1 mRNA levels and tumor growth rate (rho = 0.6, p = 0.026). The association remained significant in exploratory multivariable and robust regression analyses adjusting for covariates. CONCLUSIONS: Higher PD-L1 mRNA expression correlated with accelerated tumor growth in extremity GCTB. These exploratory findings suggest PD-L1 may serve as a potential biomarker of tumor aggressiveness, warranting validation in larger cohorts. FAU - Lee, Youngkeun AU - Lee Y AUID- ORCID: 0000-0003-2409-6097 AD - Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea. FAU - Choi, Ji-Yoon AU - Choi JY AUID- ORCID: 0009-0007-4766-273X AD - Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea. FAU - Kim, Min-Jeong AU - Kim MJ AUID- ORCID: 0009-0009-4535-5044 AD - Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea. FAU - Seo, Sung Wook AU - Seo SW AUID- ORCID: 0000-0001-8643-7825 AD - Department of Orthopedic Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 06351, Korea. sungwseo@skku.edu. LA - eng GR - RS-2021-NR057970/National Research Foundation of Korea/ PT - Journal Article DEP - 20260105 PL - England TA - BMC Musculoskelet Disord JT - BMC musculoskeletal disorders JID - 100968565 RN - 0 (B7-H1 Antigen) RN - 0 (CD274 protein, human) RN - 0 (RNA, Messenger) RN - 0 (Biomarkers, Tumor) SB - IM MH - Humans MH - *B7-H1 Antigen/genetics/metabolism MH - Male MH - Female MH - *Giant Cell Tumor of Bone/pathology/diagnostic imaging/genetics/surgery/metabolism MH - Retrospective Studies MH - Magnetic Resonance Imaging MH - Adult MH - *Bone Neoplasms/pathology/diagnostic imaging/genetics/metabolism/surgery MH - *RNA, Messenger/metabolism/genetics MH - Middle Aged MH - Young Adult MH - Tumor Burden MH - Adolescent MH - Biomarkers, Tumor/genetics PMC - PMC12930590 OTO - NOTNLM OT - Denosumab OT - Giant cell tumor of bone OT - PD-L1 OT - Real-time PCR OT - Tumor growth rate COIS- Declarations. Ethics approval and consent to participate: This single-institution retrospective study was approved by the Institutional Review Board of Samsung Medical Center (IRB No. 2020-02-015). All procedures were performed in accordance with the ethical standards of the institutional and national research committee and with the 1964 Declaration of Helsinki. Written informed consent for research use of archived tissue and imaging data was obtained from all patients. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/06 13:06 MHDA- 2026/06/27 00:57 PMCR- 2026/01/05 CRDT- 2026/01/06 11:16 PHST- 2025/11/06 00:00 [received] PHST- 2025/12/26 00:00 [accepted] PHST- 2026/06/27 00:57 [medline] PHST- 2026/01/06 13:06 [pubmed] PHST- 2026/01/06 11:16 [entrez] PHST- 2026/01/05 00:00 [pmc-release] AID - 10.1186/s12891-025-09468-0 [pii] AID - 9468 [pii] AID - 10.1186/s12891-025-09468-0 [doi] PST - epublish SO - BMC Musculoskelet Disord. 2026 Jan 5;27(1):178. doi: 10.1186/s12891-025-09468-0. PMID- 41491340 OWN - NLM STAT- MEDLINE DCOM- 20260504 LR - 20260802 IS - 1467-789X (Electronic) IS - 1467-7881 (Linking) VI - 27 IP - 6 DP - 2026 Jun TI - A Systematic Review Identifying Critical Evidence Gaps in Reporting Dietary Change in Randomized Controlled Trials Prescribing Liraglutide, Semaglutide, or Tirzepatide. PG - e70077 LID - 10.1111/obr.70077 [doi] AB - INTRODUCTION: With the growing use of GLP-1/GIP receptor agonist medications, their impact on dietary intake and quality remains unclear. This systematic review examined how randomized controlled trials (RCT) prescribing liraglutide, semaglutide, or tirzepatide assessed and reported dietary intake and quality as outcome measures, alongside weight loss and/or glycemic control, and identified gaps in the use and methodological quality of dietary assessment methods. METHODS: Medline, Embase, Cochrane, Scopus, and CINAHL were systematically searched between January 2008-January 2025 (adults) and January 2014-January 2025 (children/adolescents). The review was registered with the Open Science Framework (DOI: 10.17605/OSF.IO/XPNGY). RESULTS: Forty-three articles from 41 unique RCTs, comprising 50,690 participants (n = 688 children/adolescents, n = 50,002 adults) were included. Except for two studies targeting adults (one published and one unpublished data from an included study), this review found no other studies that assessed or reported dietary intake or changes in diet. Both reported a reduction in the total energy intake and altered macronutrient distribution in the medication plus diet group, although one was not significantly different from medication alone. Quality of assessment methods used was categorized as "poor" and "acceptable," respectively. These results highlight a critical gap in the literature. CONCLUSION: Only 2/41 studies ( approximately 5%) reported or assessed dietary intake or evaluated diet changes secondary to GLP-1/GIP RA medication use. This review highlights a major gap in the evidence requiring urgent attention. More high-quality research, using validated dietary assessment methods as outcome measures in RCTs is needed to understand how these medications impact diet and diet quality, nutrient intake, and chronic disease risk. CI - (c) 2026 World Obesity Federation. FAU - Jansson, Anna K AU - Jansson AK AUID- ORCID: 0000-0001-9039-2033 AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Gomez-Martin, Maria AU - Gomez-Martin M AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Hedin, Linnea AU - Hedin L AUID- ORCID: 0000-0002-5576-5276 AD - Department of Medicine, Huddinge, Karolinska Institute, Stockholm, Sweden. AD - Allied Health Professionals, Karolinska University Hospital, Stockholm, Sweden. FAU - Clarke, Erin D AU - Clarke ED AUID- ORCID: 0000-0001-8250-5990 AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Cross, Victoria AU - Cross V AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Stanford, Jordan AU - Stanford J AUID- ORCID: 0000-0003-3541-8960 AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Taylor, Rachael M AU - Taylor RM AUID- ORCID: 0000-0002-1895-4123 AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Bogl, Leonie H AU - Bogl LH AD - Department of Health Professions, Division of Nutrition and Dietetics, Bern University of Applied Sciences, Bern, Switzerland. FAU - De Vlieger, Nienke AU - De Vlieger N AD - School of Environmental & Life Sciences, College of Engineering, Science & Environment, University of Newcastle, Ourimbah, New South Wales, Australia. FAU - Koochek, Afsaneh AU - Koochek A AD - Department of Food Studies, Nutrition and Dietetics, Uppsala University, Uppsala, Sweden. FAU - Lof, Marie AU - Lof M AUID- ORCID: 0000-0002-2273-4430 AD - Department of Medicine, Huddinge, Karolinska Institute, Stockholm, Sweden. FAU - Asher, Roberta C AU - Asher RC AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Burrows, Tracy AU - Burrows T AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Bucher, Tamara AU - Bucher T AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - Department of Health Professions, Division of Nutrition and Dietetics, Bern University of Applied Sciences, Bern, Switzerland. FAU - Sullivan, Clair AU - Sullivan C AD - Queensland Digital Health Centre, University of Queensland, St Lucia, Queensland, Australia. AD - Metro North Health, Herston, Queensland, Australia. FAU - Nowicka, Paulina AU - Nowicka P AD - Department of Food Studies, Nutrition and Dietetics, Uppsala University, Uppsala, Sweden. FAU - Collins, Clare E AU - Collins CE AUID- ORCID: 0000-0003-3298-756X AD - Food and Nutrition Research Program, Hunter Medical Research Institute, New Lambton Heights, New South Wales, Australia. AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, New South Wales, Australia. LA - eng GR - APP2009340/National Health and Medical Research Council/ GR - APP1173681/National Health and Medical Research Council/ PT - Journal Article PT - Research Support, U.S. Gov't, Non-P.H.S. PT - Systematic Review DEP - 20260105 PL - England TA - Obes Rev JT - Obesity reviews : an official journal of the International Association for the Study of Obesity JID - 100897395 RN - 839I73S42A (Liraglutide) RN - 62340-29-8 (Glucagon-Like Peptides) RN - OYN3CCI6QE (Tirzepatide) RN - 0 (Hypoglycemic Agents) SB - IM MH - Humans MH - *Liraglutide/therapeutic use MH - *Glucagon-Like Peptides/therapeutic use MH - Randomized Controlled Trials as Topic MH - *Tirzepatide/therapeutic use MH - *Hypoglycemic Agents/therapeutic use MH - Child MH - *Diet MH - Adult MH - *Obesity/drug therapy MH - Evidence Gaps OTO - NOTNLM OT - diet quality OT - dietary outcomes OT - glucagon-like peptide-1 agonists OT - nutrition EDAT- 2026/01/06 13:05 MHDA- 2026/05/04 06:32 CRDT- 2026/01/06 11:10 PHST- 2025/10/02 00:00 [revised] PHST- 2025/06/10 00:00 [received] PHST- 2025/12/09 00:00 [accepted] PHST- 2026/05/04 06:32 [medline] PHST- 2026/01/06 13:05 [pubmed] PHST- 2026/01/06 11:10 [entrez] AID - 10.1111/obr.70077 [doi] PST - ppublish SO - Obes Rev. 2026 Jun;27(6):e70077. doi: 10.1111/obr.70077. Epub 2026 Jan 5. PMID- 41490577 OWN - NLM STAT- MEDLINE DCOM- 20260106 LR - 20260825 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 15 DP - 2026 Jan 5 TI - Tailored Individual Follow-Ups Versus a One-Day Group Course in Patients With Long COVID (Post- COVID-19 Condition): Protocol for a Randomized Controlled Trial. PG - e74113 LID - 10.2196/74113 [doi] LID - e74113 AB - BACKGROUND: The high prevalence of patients with post-COVID-19 condition, also called long COVID, even among those with mild initial disease, may have a large impact on both the individual and society. Disability in everyday life, reduced health-related quality of life and work capacity, strain on the health care system, and substantial socioeconomic costs are associated with long COVID. More research to investigate the effectiveness of rehabilitation services is warranted. OBJECTIVE: This study aims to examine the effectiveness of tailored individual follow-ups versus a 1-day group course in patients with long COVID. Additionally, the feasibility and use of a mobile app for self-monitoring goal achievement will be assessed. METHODS: This is a single-center, parallel-group, superiority randomized controlled trial with a 1:1 allocation ratio. A total of 62 outpatients aged 18-65 years with long COVID will be randomized to either a rehabilitation program with individual follow-up consultations or a 1-day self-management group course. The individual intervention incorporates setting goals, teaching cognitive behavioral strategies, energy management (pacing), and a supervised gradual increase in both physical and cognitive activities tailored to individual tolerance levels. The primary outcome is the between-group difference in health-related quality of life, measured using the EQ-5D-5L index at 6 months. Secondary outcomes include improvements in symptoms, work participation, neurocognitive function, and app usability, assessed at 3, 6, and 12 months, depending on the outcome measure. RESULTS: Data enrollment started in October 2023. A total of 62 participants were included by November 2024. Data collection is planned to be completed in November 2025. CONCLUSIONS: Long COVID poses substantial challenges for both individuals and society, underscoring the need for effective rehabilitation strategies. This study will provide valuable insights into the benefits of an individualized outpatient rehabilitation program. The results from this clinical trial will help guide future treatment recommendations and may improve long-term outcomes for affected patients. Additionally, the study will generate important knowledge about neuropsychological function and digital self-management tools in long COVID rehabilitation. CI - (c) Marte Wilson, Synne Garder Pedersen, Nina Langeland, Rebecca Jane Cox, Pal Aukrust, Tuva B Dahl, Axel Sandvig, Maja Wilhelmsen. Originally published in JMIR Research Protocols (https://www.researchprotocols.org). FAU - Wilson, Marte AU - Wilson M AUID- ORCID: 0009-0005-3688-0470 AD - Department of Rehabilitation, University Hospital of North Norway, Tromso, Norway. FAU - Pedersen, Synne Garder AU - Pedersen SG AUID- ORCID: 0000-0003-3744-7466 AD - Department of Rehabilitation, University Hospital of North Norway, Tromso, Norway. AD - Institute of Health and Society, Research Centre for Habilitation and Rehabilitation Model and Services (CHARM), Faculty of Medicine, University of Oslo, Oslo, Norway. FAU - Langeland, Nina AU - Langeland N AUID- ORCID: 0000-0003-0278-1616 AD - Department of Clinical Science, University of Bergen, Bergen, Norway. AD - Department of Medicine, Haukeland University Hospital, Bergen, Vestland, Norway. AD - Norwegian Institute for Public Health, Oslo, Norway. FAU - Cox, Rebecca Jane AU - Cox RJ AUID- ORCID: 0000-0002-8341-4078 AD - Department of Clinical Science, University of Bergen, Bergen, Norway. AD - Influenza Centre, Department of Microbiology, Haukeland University Hospital, Bergen, Vestland, Norway. FAU - Aukrust, Pal AU - Aukrust P AUID- ORCID: 0000-0003-0919-836X AD - Research Institute of Internal Medicine, Rikshospitalet, Oslo University Hospital, Oslo, Norway. AD - Faculty of Medicine, University of Oslo, Oslo, Norway. FAU - Dahl, Tuva B AU - Dahl TB AUID- ORCID: 0000-0001-7818-9411 AD - Research Institute of Internal Medicine, Rikshospitalet, Oslo University Hospital, Oslo, Norway. FAU - Sandvig, Axel AU - Sandvig A AUID- ORCID: 0000-0003-0087-7075 AD - Department of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway. FAU - Wilhelmsen, Maja AU - Wilhelmsen M AUID- ORCID: 0000-0002-6425-9957 AD - Department of Rehabilitation, University Hospital of North Norway, Tromso, Norway. AD - Institute of Health and Society, Research Centre for Habilitation and Rehabilitation Model and Services (CHARM), Faculty of Medicine, University of Oslo, Oslo, Norway. AD - Department of Clinical Medicine, UiT The Arctic University of Norway, Postboks 6050 Stakkevollan, Tromso, 9037, Norway, +47 99001559. LA - eng SI - ClinicalTrials.gov/NCT06085911 PT - Clinical Trial Protocol PT - Journal Article DEP - 20260105 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - *COVID-19/rehabilitation/complications MH - Adult MH - Middle Aged MH - Quality of Life MH - Aged MH - Adolescent MH - Young Adult MH - Male MH - Female MH - SARS-CoV-2 MH - Randomized Controlled Trials as Topic MH - Mobile Applications MH - Self-Management/methods MH - Post-Acute COVID-19 Syndrome MH - Equivalence Trials as Topic PMC - PMC12768394 OTO - NOTNLM OT - cognitive behavioral therapy OT - cognitive training OT - exercise OT - fatigue OT - graded activity OT - mobile apps OT - postacute COVID-19 syndrome OT - randomized controlled trial OT - rehabilitation OT - telerehabilitation COIS- Conflicts of Interest: None declared. EDAT- 2026/01/06 13:06 MHDA- 2026/01/06 13:07 PMCR- 2026/01/05 CRDT- 2026/01/06 10:44 PHST- 2025/03/19 00:00 [received] PHST- 2025/11/10 00:00 [accepted] PHST- 2026/01/06 13:07 [medline] PHST- 2026/01/06 13:06 [pubmed] PHST- 2026/01/06 10:44 [entrez] PHST- 2026/01/05 00:00 [pmc-release] AID - v15i1e74113 [pii] AID - 74113 [pii] AID - 10.2196/74113 [doi] PST - epublish SO - JMIR Res Protoc. 2026 Jan 5;15:e74113. doi: 10.2196/74113. PMID- 41489001 OWN - NLM STAT- MEDLINE DCOM- 20260105 LR - 20260107 IS - 1365-277X (Electronic) IS - 0952-3871 (Print) IS - 0952-3871 (Linking) VI - 39 IP - 1 DP - 2026 Feb TI - Food Frequency Questionnaires Validated in Brazil: A Scoping Review. PG - e70190 LID - 10.1111/jhn.70190 [doi] LID - e70190 AB - OBJECTIVE: To map food frequency questionnaires (FFQs) validated for the Brazilian population. METHODS: This review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping (PRISMA-ScR) guidelines and the Joanna Briggs Institute (JBI). Studies that validated FFQs specifically for the Brazilian population were included. These instruments assessed the intake of energy, nutrients, foods and food groups. Review articles and studies that did not focus on FFQ validation for Brazil or its populations were excluded. A search of articles published up to June 2025 was conducted in the PubMed/MEDLINE, LILACS, Embase, Web of Science (ISI), Scopus and Google Scholar databases. RESULTS: A total of 69 articles were identified, dating back to the late 1990s: Southeast (n = 35), South (n = 12), Northeast (n = 10), Central-West (n = 4), North (n = 1) and studies covering two or more regions or populations (n = 7). The FFQs were validated in populations of children and adolescents (n = 18), adults and older adults (n = 36) and women (n = 15). These studies differed in terms of food list size, portion size and the number of frequency categories. CONCLUSION: Compiling and disseminating FFQs validated in Brazil will improve their use in clinical practice and provide a valuable resource for designing future research on food consumption. CI - (c) 2026 The Author(s). Journal of Human Nutrition and Dietetics published by John Wiley & Sons Ltd on behalf of British Dietetic Association. FAU - Brito Barros, Acsa Nara A AU - Brito Barros ANA AUID- ORCID: 0000-0002-3658-287X AD - Graduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil. FAU - Felipe, Maria Luisa N AU - Felipe MLN AD - Graduate Program in Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil. FAU - Bezerra, Maria Fernanda S AU - Bezerra MFS AD - Nutrition Undergraduate Course, Federal University of Rio Grande do Norte, Natal, Brazil. FAU - Leite-Lais, Lucia AU - Leite-Lais L AD - Department of Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil. FAU - Pedrosa, Lucia Fatima Campos AU - Pedrosa LFC AD - Graduate Program in Health Sciences, Federal University of Rio Grande do Norte, Natal, Brazil. AD - Graduate Program in Nutrition, Federal University of Rio Grande do Norte, Natal, Brazil. LA - eng GR - 001/Coordination for the Improvement of Higher Education Personnel, Brazil/ PT - Journal Article PT - Scoping Review PL - England TA - J Hum Nutr Diet JT - Journal of human nutrition and dietetics : the official journal of the British Dietetic Association JID - 8904840 SB - IM MH - Adolescent MH - Adult MH - Aged MH - Child MH - Female MH - Humans MH - Male MH - Middle Aged MH - Brazil MH - *Diet/statistics & numerical data MH - *Diet Surveys/standards/methods MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Validation Studies as Topic PMC - PMC12766558 COIS- The authors declare no conflicts of interest. EDAT- 2026/01/05 06:46 MHDA- 2026/01/05 12:47 PMCR- 2026/01/05 CRDT- 2026/01/05 05:44 PHST- 2025/12/12 00:00 [revised] PHST- 2025/10/17 00:00 [received] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/01/05 12:47 [medline] PHST- 2026/01/05 06:46 [pubmed] PHST- 2026/01/05 05:44 [entrez] PHST- 2026/01/05 00:00 [pmc-release] AID - JHN70190 [pii] AID - 10.1111/jhn.70190 [doi] PST - ppublish SO - J Hum Nutr Diet. 2026 Feb;39(1):e70190. doi: 10.1111/jhn.70190. PMID- 41487499 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260105 LR - 20260108 IS - 1663-9812 (Print) IS - 1663-9812 (Electronic) IS - 1663-9812 (Linking) VI - 16 DP - 2025 TI - The dietary phytochemicals carnosic acid and sulforaphane regulate inflammatory markers in ulcerative colitis patient-derived colonoids. PG - 1696576 LID - 10.3389/fphar.2025.1696576 [doi] LID - 1696576 AB - INTRODUCTION: The inflammatory bowel disease (IBD) ulcerative colitis (UC) is characterized by continuous inflammation of the colon with erosion and ulcers. Diagnosis typically occurs in patients between their late teens and mid-30s with no cure. Available therapeutics are efficient at controlling symptoms however, they have many serious adverse effects. Thus, additional therapies with limited adverse effects are needed to complement these drugs. In this study, we evaluated the anti-inflammatory potential of carnosic acid (CA), the most abundant diterpene in rosemary (Salvia rosmarinus) and sulforaphane (SFN), an isothiocyanate found in cruciferous vegetables. METHODS: We used colonic epithelial organoids (colonoids) derived from non-IBD and UC patients as a physiologically relevant testing platform for both phytochemicals. These patient-derived colonoids are a representative model that recapitulates the parent epithelial tissue including its cellular composition and 3D structure. Moreover, we cultured the colonoids at 2% O(2) to better approximate the low oxygen level (physioxia) observed in the colon crypts. To assess the effects of CA and SFN in the nuclear factor erythroid 2-related factor 2 (NRF2) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) pathways, we studied modulation of inflammatory cytokines through a 40-plex chemokine assay and ELISA, as well as gene and protein expression of target genes with qPCR and western blot, respectively. RESULTS: Through these techniques, we observed that CA and SFN decreased inflammatory markers and promoted NRF2 activity in patient-derived colonoids. Additionally, SFN and CA modulated the expression and secretion of the NF-kappaB promoted antibacterial peptide neutrophil gelatinase-associated lipocalin which is highly expressed in the inflamed colonic epithelium and has been suggested as a biomarker for active UC. DISCUSSION: Together, the results validated the use of colonoids as a pharmacological testing platform for phytochemicals, and that CA and SFN promote NRF2 activation and decrease inflammation in a human physiologically relevant UC model. CI - Copyright (c) 2025 Rivera Rodriguez, Saeterstad, Chattergoon Ali, Selvik, Bakke, Bruland and Johnson. FAU - Rivera Rodriguez, Rocio AU - Rivera Rodriguez R AD - Department of Pharmaceutical Sciences, Retzky College of Pharmacy, University of Illinois Chicago, Chicago, IL, United States. FAU - Saeterstad, Siri AU - Saeterstad S AD - Department of Clinical and Molecular Medicine (IKOM), Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim, Norway. FAU - Chattergoon Ali, Ann-Therese AU - Chattergoon Ali AT AD - Department of Clinical and Molecular Medicine (IKOM), Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim, Norway. FAU - Selvik, Linn-Karina M AU - Selvik LM AD - Department of Clinical and Molecular Medicine (IKOM), Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim, Norway. FAU - Bakke, Ingunn AU - Bakke I AD - Department of Clinical and Molecular Medicine (IKOM), Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim, Norway. AD - Clinic of Laboratory Medicine, St. Olav's University Hospital, Trondheim, Norway. FAU - Bruland, Torunn AU - Bruland T AD - Department of Clinical and Molecular Medicine (IKOM), Faculty of Medicine and Health Sciences, NTNU - Norwegian University of Science and Technology, Trondheim, Norway. AD - Department of Gastroenterology and Hepatology, Clinic of Medicine, St. Olav's University Hospital, Trondheim, Norway. FAU - Johnson, Jeremy J AU - Johnson JJ AD - Department of Pharmacy Practice, Retzky College of Pharmacy, University of Illinois Chicago, Chicago, IL, United States. LA - eng GR - R37 CA227101/CA/NCI NIH HHS/United States PT - Journal Article DEP - 20251218 PL - Switzerland TA - Front Pharmacol JT - Frontiers in pharmacology JID - 101548923 PMC - PMC12756672 OTO - NOTNLM OT - LCN2 OT - NGAL OT - NRF2 OT - anti-inflammatory OT - inflammatory bowel disease OT - intestinal epithelial organoid COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/05 06:47 MHDA- 2026/01/05 06:48 PMCR- 2025/12/18 CRDT- 2026/01/05 05:20 PHST- 2025/09/01 00:00 [received] PHST- 2025/10/23 00:00 [revised] PHST- 2025/11/17 00:00 [accepted] PHST- 2026/01/05 06:48 [medline] PHST- 2026/01/05 06:47 [pubmed] PHST- 2026/01/05 05:20 [entrez] PHST- 2025/12/18 00:00 [pmc-release] AID - 1696576 [pii] AID - 10.3389/fphar.2025.1696576 [doi] PST - epublish SO - Front Pharmacol. 2025 Dec 18;16:1696576. doi: 10.3389/fphar.2025.1696576. eCollection 2025. PMID- 41486964 OWN - NLM STAT- MEDLINE DCOM- 20260711 LR - 20260904 IS - 1464-5165 (Electronic) IS - 0963-8288 (Linking) VI - 48 IP - 15 DP - 2026 Jul TI - A 6-minute adaptation of the wheelchair propulsion test to assess and estimate aerobic fitness in young wheelchair users with spina bifida: criterion validity and test-retest reliability. PG - 5004-5016 LID - 10.1080/09638288.2025.2609816 [doi] AB - PURPOSE: To determine the validity and reliability of an adapted 6-minute wheelchair propulsion test, referred here as the 6 m-WPT, to assess aerobic fitness in SBw. A secondary aim was to develop a prediction model for oxygen uptake (VO(2)peak) derived from this adapted test. MATERIALS AND METHODS: This cross-sectional observational study included a test-retest design. Twenty-four SBw (median age 10.0 [10.0-12.4] years) completed the arm-crank cardiopulmonary exercise test (CPET), the 10-metre Shuttle Ride Test (10 m-SRT), and the 6 m-WPT to examine the 6 m-WPT validity. For reliability analysis, 50% of SBw performed the 6 m-WPT twice. Thirteen SBw were included in the development of the prediction model. RESULTS: Only the respiratory exchange ratio between the CPET and the 6 m-WPT, and the distance between the 10 m-SRT and the ACPT, were significantly different (p < 0.05). Correlations among the tests were moderate to strong (r = 0.55-0.89). Excellent to good reliability (ICC = 0.75 to > 0.90) and agreement were found for the test and retest. The 6 m-WPT distance and patient body mass predicted 72% of VO(2)peak. CONCLUSION: The 6 m-WPT is a valid and reliable test for assessing aerobic fitness in SBw. The 6 m-WPT distance and patient body mass may be used to estimate VO(2)peak. FAU - Davoli, Gabriela Barroso de Queiroz AU - Davoli GBQ AUID- ORCID: 0000-0002-4981-3868 AD - Department of Health Science of Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil. FAU - Crescencio, Julio Cesar AU - Crescencio JC AUID- ORCID: 0000-0002-7523-5168 AD - Department of Cardiology of Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil. FAU - Leonardi-Figueiredo, Marisa Maia AU - Leonardi-Figueiredo MM AD - Department of Health Science of Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil. FAU - Manso, Paulo Henrique AU - Manso PH AD - Department of Paediatrics and Child Care of Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil. FAU - Borghi E Silva, Audrey AU - Borghi E Silva A AD - Department of Physiotherapy, Federal University of Sao Carlos, Sao Carlos, Brazil. FAU - Carvalho, Celso Ricardo Fernando de AU - Carvalho CRF AD - Department of Physiotherapy, Speech therapy and Occupational therapy of Medical School, University of Sao Paulo, Sao Paulo, Brazil. FAU - Kalika Koch Groszmann, Vera Hermina AU - Kalika Koch Groszmann VH AD - Department of Paediatric of Medical School, University of Sao Paulo, Sao Paulo, Brazil. FAU - Mattiello-Sverzut, Ana Claudia AU - Mattiello-Sverzut AC AUID- ORCID: 0000-0002-4181-0718 AD - Department of Health Science of Ribeirao Preto Medical School, University of Sao Paulo, Sao Paulo, Brazil. LA - eng PT - Journal Article PT - Observational Study PT - Validation Study DEP - 20260105 PL - England TA - Disabil Rehabil JT - Disability and rehabilitation JID - 9207179 SB - IM MH - Humans MH - *Wheelchairs MH - Reproducibility of Results MH - *Exercise Test/methods MH - Cross-Sectional Studies MH - *Oxygen Consumption/physiology MH - Female MH - Male MH - Child MH - *Spinal Dysraphism/rehabilitation/physiopathology MH - *Physical Fitness/physiology MH - *Cardiorespiratory Fitness OAB - The 12-minute wheelchair propulsion test was adapted into a 6-minute version (6m-WPT) to provide a less demanding and more dynamic field test for most wheelchair-using patients with spina bifida.The adapted 6 m-WPT demonstrated adequate validity and reliability, making it an effective tool for assessing aerobic fitness in wheelchair users with spina bifida.The distance covered in the adapted 6m-WPT, together with the participant's body mass, predicted 72% of peak oxygen uptake (VO(2)peak), supporting its applicability as a practical and feasible test for routine clinical use. OABL- eng OTO - NOTNLM OT - Field test OT - aerobic fitness OT - prediction model OT - upper limbs OT - wheelchair EDAT- 2026/01/05 06:47 MHDA- 2026/07/12 00:55 CRDT- 2026/01/05 04:13 PHST- 2026/07/12 00:55 [medline] PHST- 2026/01/05 06:47 [pubmed] PHST- 2026/01/05 04:13 [entrez] AID - 10.1080/09638288.2025.2609816 [doi] PST - ppublish SO - Disabil Rehabil. 2026 Jul;48(15):5004-5016. doi: 10.1080/09638288.2025.2609816. Epub 2026 Jan 5. PMID- 41486779 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20260813 IS - 2328-9503 (Electronic) IS - 2328-9503 (Linking) VI - 13 IP - 6 DP - 2026 Jun TI - Predicting Loss of Ambulation in Limb Girdle Muscular Dystrophy R9. PG - 1154-1159 LID - 10.1002/acn3.70299 [doi] AB - BACKGROUND: Limb girdle muscular dystrophy type R9 (LGMDR9) results from biallelic variants in FKRP. There is limited data to predict loss of ambulation (LOA) among those with LGMDR9. METHODS: Participants in an ongoing dystroglycanopathy natural history study (NCT00313677) with FKRP variants who had achieved ambulation and were more than 3 years old were included (n = 97). LOA was defined as self-reported full-time wheelchair use, weakness preventing completion of the 10-m walk-run test (10MWT) or 10MWT time > 30 s. Interval-censored time-to-event analysis was used to determine median age at LOA. Receiver operating characteristic curves were used to examine the ability of 10MWT and 4-stair climb (4SC) times to predict LOA. RESULTS: Of 97 participants, 55 (57%) were homozygous for the c.826C>A founder variant. Thirty-one participants lost ambulation; 15 (49%) were homozygous for c.826C>A. Earliest age at LOA was 9 years (non-homozygous for c.826C>A). Median age at LOA for the cohort was 46.0 years. Performances on 10MWT and 4SC were highly predictive of LOA within 3 years, with areas under the ROC curve of 0.89 (10MWT) and 0.87 (4SC) when genotype was included in analysis. Optimal cutoffs for predicting LOA within 3 years differed by genotype and had acceptable sensitivity and specificity. DISCUSSION: LOA among those with LGMDR9 is strongly predicted by performance on 10MWT and 4SC. These results demonstrate the real-world significance of standardized motor function tests used in LGMDR9 clinical trials and aid in anticipatory guidance. CI - (c) 2026 The Author(s). Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. FAU - Miller, Chandra L AU - Miller CL AUID- ORCID: 0000-0002-5550-6936 AD - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA. FAU - Coffey, Lauren N AU - Coffey LN AD - University of Iowa Carver College of Medicine, Iowa City, Iowa, USA. FAU - Mockler, Shelley R H AU - Mockler SRH AD - Center for Disabilities and Development, University of Iowa Health Care Stead Family Children's Hospital, Iowa City, Iowa, USA. FAU - Laubscher, Katie M AU - Laubscher KM AD - Center for Disabilities and Development, University of Iowa Health Care Stead Family Children's Hospital, Iowa City, Iowa, USA. FAU - Stephan, Carrie M AU - Stephan CM AD - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA. FAU - Zimmerman, M Bridget AU - Zimmerman MB AD - Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, Iowa, USA. FAU - Mathews, Katherine D AU - Mathews KD AD - Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA. AD - Department of Neurology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA. LA - eng SI - ClinicalTrials.gov/NCT00313677 GR - U54 NS053672/NS/NINDS NIH HHS/United States GR - NIH U54 NS053672/NH/NIH HHS/United States GR - NIH U54 NS053672/NH/NIH HHS/United States PT - Journal Article PT - Observational Study PT - Research Support, N.I.H., Extramural DEP - 20260104 PL - United States TA - Ann Clin Transl Neurol JT - Annals of clinical and translational neurology JID - 101623278 RN - EC 2.4.2.- (FKRP protein, human) RN - EC 2.4.2.- (Pentosyltransferases) SB - IM MH - Adolescent MH - Adult MH - Child MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Mobility Limitation MH - *Muscular Dystrophies, Limb-Girdle/genetics/physiopathology/diagnosis MH - Pentosyltransferases/genetics MH - *Walking/physiology PMC - PMC13251427 OTO - NOTNLM OT - FKRP OT - dystroglycanopathy OT - limb-girdle muscular dystrophy OT - loss of ambulation COIS- Chandra L. Miller, DNP, receives funding from the Paul D. Wellstone Muscular Dystrophy Cooperative Research Center grant (NIH U54 NS053672), and clinical trial or registry funding from AMO, AskBio, AveXis, Avidity, Biohaven, Capricor, Cure Duchenne, Edgewise, Genethon, GRASP, Italfarmaco, Larimar, MDA, ML Bio, Pfizer, PPMD, PTC Therapeutics, RegenxBio, Sarepta Therapeutics, and Scholar Rock. Lauren N. Coffey, BS, received funding from the University of Iowa Carver College of Medicine and the Paul D. Wellstone Muscular Dystrophy Cooperative Research Center grant (NIH U54 NS053672). Shelley R. H. Mockler, DSc, receives funding from NIH grant 2 U54 NS053672-11, and Italfarmaco, ML Bio Solutions, Edgewise Therapeutics, Biohaven, Capricor Therapeutics Inc., Sarepta Therapeutics, Ask Bio, Pfizer Inc., Scholar Rock, Avidity Biosciences, and Shire/Takeda Pharmaceutical. She serves as a paid consultant for Avidity Biosciences and ATOM International. Katie M. Laubscher, DPT, receives funding from NIH grant 2 U54 NS053672-11, Edgewise Therapeutics, ML Bio Solutions, Ask Bio, Capricor Therapeutics Inc., Scholar Rock, Avidity Biosciences, Biohaven, Italfarmaco, and Sarepta Therapeutics Inc. She serves as a paid consultant for ATOM International. Carrie M. Stephan, MA, receives funding from NIH grant 2 U54 NS053672-11, and Sarepta Therapeutics Inc. Dr. M. Bridget Zimmerman receives funding from NIH grants 5 P50 NS053672, 1 R01 NR017610-01A1, 4 UH3 AR076387-02, 5 R01 CA246540-05, 5 R01 HL153095-04, 5 R01 AR077418-04, 1 R25 HL161716-02, 5 R01 HD104616-03, 5 R01 HL164662-02, 1 R56 AG080101-01A1, and 1 R01 HL173483-01. Katherine D. Mathews receives research funding from the Paul D. Wellstone Muscular Dystrophy Cooperative (NIH U54 NS053672) and the Centers for Disease Control (U01 DD001248). She serves as an advisory board member for MDA and the FSH Society; is a board member for the Friedreich Ataxia Research Alliance (FARA); receives clinical trial funding from PTC Therapeutics, Sarepta Therapeutics, Pfizer, Italfarmaco, Biohaven, AMO, Capricor, AskBio, ML Bio, Scholar Rock, Avidity, Edgewise; serves as an industry consultant for Sarepta, AskBio, ML Bio, and Edgewise; and serves on safety review boards for Sarepta and Dyne. EDAT- 2026/01/05 06:47 MHDA- 2026/06/13 00:38 PMCR- 2026/01/04 CRDT- 2026/01/05 02:34 PHST- 2025/11/25 00:00 [revised] PHST- 2025/10/19 00:00 [received] PHST- 2025/12/08 00:00 [accepted] PHST- 2026/06/13 00:38 [medline] PHST- 2026/01/05 06:47 [pubmed] PHST- 2026/01/05 02:34 [entrez] PHST- 2026/01/04 00:00 [pmc-release] AID - ACN370299 [pii] AID - 10.1002/acn3.70299 [doi] PST - ppublish SO - Ann Clin Transl Neurol. 2026 Jun;13(6):1154-1159. doi: 10.1002/acn3.70299. Epub 2026 Jan 4. PMID- 41486649 OWN - NLM STAT- MEDLINE DCOM- 20260308 LR - 20260308 IS - 1097-0010 (Electronic) IS - 0022-5142 (Linking) VI - 106 IP - 5 DP - 2026 Mar 30 TI - Eat mindfully, live spiritually, sustain our world. PG - 2870-2887 LID - 10.1002/jsfa.70384 [doi] AB - BACKGROUND: This study investigates the relationship between spirituality and sustainable eating behaviours, addressing a gap in the Italian literature. Although food sustainability is often examined through economic, environmental or health-related lenses, recent research has highlighted the growing importance of ethical and spiritual values in shaping consumer choices. Spirituality, understood as a personal connection with nature, a sense of duty and inner balance, can motivate individuals to adopt more environmentally conscious dietary habits. Based on a modified Norm Activation Model and incorporating spiritual constructs, the research examines if (and how) spirituality aspects affect sustainable consumer behaviours. An online survey was administered to individuals responsible for household grocery decisions, using validated psychometric scales to assess environmental attitudes, ecological identity, spirituality and eating behaviours. Data were analysed through confirmatory factor analysis and hierarchical multiple regression. RESULTS: The findings demonstrate that spiritual dimensions, especially duty orientation and equanimity, positively affect personal norms, which significantly predict sustainable eating behaviours. Additionally, awareness of environmental consequences and a sense of personal responsibility emerged as key mediators. CONCLUSION: The findings suggest that spirituality can serve as a powerful motivational driver for sustainability, supporting more ethical, mindful and low-impact food choices. Educational and policy interventions that recognize and engage with spiritual values may enhance their effectiveness in promoting sustainable food systems. (c) 2026 Society of Chemical Industry. CI - (c) 2026 Society of Chemical Industry. FAU - Palmieri, Nadia AU - Palmieri N AUID- ORCID: 0000-0001-7178-3733 AD - Department of Economics and Legal Studies, University of Naples "Parthenope", Naples, Italy. FAU - Mastellone, Riccardo AU - Mastellone R AD - Department of Economics and Legal Studies, University of Naples "Parthenope", Naples, Italy. FAU - Boccia, Flavio AU - Boccia F AUID- ORCID: 0000-0001-6466-8841 AD - Department of Economics and Legal Studies, University of Naples "Parthenope", Naples, Italy. LA - eng PT - Journal Article DEP - 20260104 PL - England TA - J Sci Food Agric JT - Journal of the science of food and agriculture JID - 0376334 SB - IM MH - Humans MH - Adult MH - Male MH - Female MH - Middle Aged MH - *Spirituality MH - *Feeding Behavior/psychology MH - Young Adult MH - Surveys and Questionnaires MH - Italy MH - Aged MH - Adolescent MH - Consumer Behavior OTO - NOTNLM OT - Italy OT - modified norm activation model OT - spirituality impacts OT - sustainable eating behaviours EDAT- 2026/01/05 06:47 MHDA- 2026/03/08 06:38 CRDT- 2026/01/05 01:24 PHST- 2025/11/19 00:00 [revised] PHST- 2025/08/22 00:00 [received] PHST- 2025/12/02 00:00 [accepted] PHST- 2026/03/08 06:38 [medline] PHST- 2026/01/05 06:47 [pubmed] PHST- 2026/01/05 01:24 [entrez] AID - 10.1002/jsfa.70384 [doi] PST - ppublish SO - J Sci Food Agric. 2026 Mar 30;106(5):2870-2887. doi: 10.1002/jsfa.70384. Epub 2026 Jan 4. PMID- 41486190 OWN - NLM STAT- MEDLINE DCOM- 20260204 LR - 20260206 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2026 Jan 5 TI - Translation & psychometrics of the Parenting Concerns Questionnaire (PCQ) in Iranian woman with breast cancer. PG - 157 LID - 10.1186/s40359-025-03899-z [doi] LID - 157 AB - OBJECTIVES: Parenting concerns are unique challenges for many breast cancer patients with children. Therefore, assessing these concerns is a critical step in psycho-oncology care. The Parenting Concerns Questionnaire (PCQ) was developed in the USA in 2012. Due to the lack of a validated tool to measure this concept in Iran, the present study was conducted to translate and determine the psychometric properties of the PCQ in Iranian women with breast cancer. METHODS: The current methodological study was conducted on 346 female Iranian breast cancer patients in 2024. The eligible patients completed a demographic and clinical information questionnaire, translated version of the PCQ, quality of life questionnaire (EORTC QLQ C30), and the Hospital Anxiety and Depression Scale (HADS). The psychometric assessment including face validity, content validity were performed. Also, construct validity was done using exploratory factor analysis (n = 176) and confirmatory factor analysis (n = 170). Reliability was examined using internal consistency. Data was analyzed using SPSS version 25 and Amos version 24. RESULTS: The content validity of index (CVI) for all of the items was between 0.8 and 1. Exploratory factor analysis identified three factors, which were accompanied by relocating several items in their dimensions. The result of the confirmatory factor analysis indicated that the fitness indicators were appropriate (RMSEA: 0.08; NFI: 0.87; CFI: 0.92; IFI: 0.92; GFI 0.88;TLI: 0.90). The convergent validity assessment demonstrated a positive correlation between parenting concerns and anxiety and depression (r = 0.490, r = 0.627, P < 0.001), and a negative correlation with the quality of life (r=-0.477, P < 0.001). The internal consistency of the questionnaire was alpha = 0.89. CONCLUSION: The Persian version of the PCQ is a valid and reliable tool to analyze the parental concerns among women with breast cancer. It is recommended that healthcare workers use this tool for psychological screenings in oncology clinics and take targeted measures to reduce the psychological burden. CI - (c) 2025. The Author(s). FAU - Dadashi, Nasrin AU - Dadashi N AUID- ORCID: 0000-0003-2576-7171 AD - Student Research Committee, Department of Medical Surgical Nursing, School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Barasteh, Salman AU - Barasteh S AUID- ORCID: 0000-0003-2042-599X AD - Nursing Care Research Center, Clinical Sciences Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran. FAU - Karami, Maryam AU - Karami M AUID- ORCID: 0000-0002-8824-2543 AD - Department of Medical Surgical Nursing, School of Nursing and Midwifery Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Gharibi, Hosein AU - Gharibi H AD - School of Nursing and Midwifery, Shahed University, Tehran, Iran. FAU - Khoubbin Khoshnazar, Tahereh AU - Khoubbin Khoshnazar T AUID- ORCID: 0000-0001-7872-1025 AD - School of Nursing and Midwifery, Iran University of Medical Sciences, Tehran, Iran. FAU - Khanali Mojen, Leila AU - Khanali Mojen L AUID- ORCID: 0000-0002-5394-7818 AD - Department of Medical Surgical Nursing, School of Nursing and Midwifery Shahid Beheshti University of Medical Sciences, Tehran, Iran. Leilakhanali@yahoo.com. LA - eng PT - Journal Article DEP - 20260105 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Female MH - Iran MH - Psychometrics MH - *Breast Neoplasms/psychology MH - Reproducibility of Results MH - Adult MH - Surveys and Questionnaires MH - *Parenting/psychology MH - Middle Aged MH - Quality of Life/psychology MH - Factor Analysis, Statistical MH - Translations MH - Anxiety/psychology PMC - PMC12870203 OTO - NOTNLM OT - Anxiety OT - Breast cancer OT - Depression OT - Parenting concerns OT - Quality of life OT - Reliability OT - Validity COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the principles of the Declaration of Helsinki. Ethics Committee of Shahid Beheshti School of Nursing and Pharmacy approved the present study with the code IR.SBMU.PHARMACY.REC.1403.067. At the beginning of the research, the goals and confidentiality of the information were explained to the participants, and informed consent was obtained from each participant. The participants were also informed that they were able to exit the study at any time, and they could receive the study results if they were willing. Consent for publication: The authors and participants have given their consent for the publication of the study. Competing interests: The authors declare no competing interests. EDAT- 2026/01/05 00:49 MHDA- 2026/02/04 11:33 PMCR- 2026/01/05 CRDT- 2026/01/04 23:21 PHST- 2025/06/12 00:00 [received] PHST- 2025/12/19 00:00 [accepted] PHST- 2026/02/04 11:33 [medline] PHST- 2026/01/05 00:49 [pubmed] PHST- 2026/01/04 23:21 [entrez] PHST- 2026/01/05 00:00 [pmc-release] AID - 10.1186/s40359-025-03899-z [pii] AID - 3899 [pii] AID - 10.1186/s40359-025-03899-z [doi] PST - epublish SO - BMC Psychol. 2026 Jan 5;14(1):157. doi: 10.1186/s40359-025-03899-z. PMID- 41486116 OWN - NLM STAT- MEDLINE DCOM- 20260203 LR - 20260207 IS - 1471-230X (Electronic) IS - 1471-230X (Linking) VI - 26 IP - 1 DP - 2026 Jan 5 TI - Environmental enteric dysfunction in well-nourished and undernourished women in Bangladesh. PG - 90 LID - 10.1186/s12876-025-04589-1 [doi] LID - 90 AB - INTRODUCTION: Environmental Enteric Dysfunction (EED) is a subacute inflammation of the small intestinal (SI) mucosa associated with undernutrition and perturbation of the SI microbiota. Its diagnosis relies on histopathological assessment of small intestinal biopsies, with a lack of validated biomarkers contributing to underdiagnosis. This study assessed the prevalence and histological features of EED in undernourished Bangladeshi women living in an urban slum in Dhaka, compared to well-nourished women from slum and non-slum areas, and examined the factors associated with histologically confirmed EED. METHODS: This analysis included non-pregnant, non-lactating Bangladeshi women aged 18-45 years classified by location of residence and nutritional status: well-nourished non-slum residents (WNNS), well-nourished slum residents (WNS), and undernourished slum residents (UNS). Data were obtained from two ongoing studies and one completed study. Well-nourished women (BMI 20-24.9 kg/m(2)) who consented to upper gastrointestinal endoscopy for functional dyspepsia were also enrolled. During endoscopy, mucosal biopsies were collected from the distal duodenum, and the presence of EED was determined by histologic assessment of lymphocyte infiltration, villous atrophy, and/or crypt hyperplasia. RESULTS: Between October 2, 2022, and June 30, 2024, 1059 WNNS and 445 WNS women were screened for eligibility. Of these, 33 WNNS and 55 WNS women underwent endoscopic evaluation. Histological data were available from a prior study of 38 UNS women. Histological examination showed EED in 21% of WNNS, 18% of WNS, and 100% of UNS women. Multiple logistic regression analysis indicated that BMI (aOR: 0.70, 95% CI: 0.58-0.85; p < 0.001) was significantly associated with the presence of EED in women in this study. CONCLUSION: Although EED was expectedly common in undernourished women, its detection in well-nourished women indicates that environmental conditions may influence intestinal health beyond nutritional status alone. These findings indicate that attention to environmental risks is important for wider groups of women and support further work to understand the pathways that lead to EED in different community settings. CI - (c) 2025. The Author(s). FAU - Mahfuz, Mustafa AU - Mahfuz M AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (Icddr,B), 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh. mustafa@icddrb.org. FAU - Hossain, Md Shabab AU - Hossain MS AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (Icddr,B), 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh. FAU - Khan, Ar-Rafi AU - Khan AR AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (Icddr,B), 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh. FAU - Mahfuz, Mehjabin Tishan AU - Mahfuz MT AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (Icddr,B), 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh. FAU - Sharmin, Rumana AU - Sharmin R AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (Icddr,B), 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh. FAU - Rezwan, A H M AU - Rezwan AHM AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (Icddr,B), 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh. FAU - Tasnim, Musarrat AU - Tasnim M AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (Icddr,B), 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh. FAU - Hasan, S M Tafsir AU - Hasan SMT AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (Icddr,B), 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh. FAU - Begum, S M Khodeza Nahar AU - Begum SMKN AD - Department of Pathology, Bangladesh Specialized Hospital, Dhaka, Bangladesh. FAU - Rahman, M Masudur AU - Rahman MM AD - Department of Gastroenterology, Manikganj Medical College, Dhaka, Bangladesh. FAU - Barratt, Michael J AU - Barratt MJ AD - The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, 63110, USA. AD - Newman Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO, 63110, USA. FAU - Gordon, Jeffrey I AU - Gordon JI AD - The Edison Family Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, MO, 63110, USA. AD - Newman Center for Gut Microbiome and Nutrition Research, Washington University School of Medicine, St. Louis, MO, 63110, USA. FAU - Ahmed, Tahmeed AU - Ahmed T AD - Nutrition Research Division, International Centre for Diarrhoeal Disease Research, Bangladesh (Icddr,B), 68 Shaheed Tajuddin Ahmed Sarani, Mohakhali, Dhaka, 1212, Bangladesh. AD - International Centre for Diarrhoeal Disease Research, Bangladesh (Icddr,B), Dhaka, 1212, Bangladesh. LA - eng GR - INV-045337/GATES/Gates Foundation/United States GR - R01 DK131107/DK/NIDDK NIH HHS/United States GR - 1R01DK131107/GF/NIH HHS/United States GR - INV-045337/GATES/Gates Foundation/United States PT - Journal Article DEP - 20260105 PL - England TA - BMC Gastroenterol JT - BMC gastroenterology JID - 100968547 SB - IM MH - Humans MH - Female MH - Bangladesh/epidemiology MH - Adult MH - *Malnutrition/complications/epidemiology MH - Young Adult MH - Adolescent MH - Middle Aged MH - *Intestinal Mucosa/pathology MH - Poverty Areas MH - Nutritional Status MH - Prevalence MH - *Intestine, Small/pathology MH - Biopsy MH - *Intestinal Diseases/epidemiology/pathology PMC - PMC12870067 OTO - NOTNLM OT - Dhaka Bangladesh OT - Environmental Enteric Dysfunction (EED) OT - Histopathologic diagnosis OT - Host-environmental-social factor associations OT - Undernutrition in adult women EDAT- 2026/01/05 00:49 MHDA- 2026/02/04 05:06 PMCR- 2026/01/05 CRDT- 2026/01/04 23:14 PHST- 2025/09/23 00:00 [received] PHST- 2025/12/26 00:00 [accepted] PHST- 2026/02/04 05:06 [medline] PHST- 2026/01/05 00:49 [pubmed] PHST- 2026/01/04 23:14 [entrez] PHST- 2026/01/05 00:00 [pmc-release] AID - 10.1186/s12876-025-04589-1 [pii] AID - 4589 [pii] AID - 10.1186/s12876-025-04589-1 [doi] PST - epublish SO - BMC Gastroenterol. 2026 Jan 5;26(1):90. doi: 10.1186/s12876-025-04589-1. PMID- 41485006 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260702 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jan 2 TI - Gaps in knowledge and prevention of kidney stone disease among Palestinian adults: findings from an online cross-sectional survey. PG - 425 LID - 10.1186/s12889-025-26098-2 [doi] LID - 425 AB - BACKGROUND: Kidney stone disease (KSD) is a common and largely preventable urological condition with rising incidence worldwide. Public knowledge, awareness, and everyday preventive practices are critical for early prevention, particularly in settings with constrained healthcare resources. This study assessed knowledge, awareness, and selected lifestyle practices related to KSD among adults in Palestine and examined sociodemographic factors associated with preventive understanding. METHODS: A cross-sectional online survey was conducted among 510 adults residing in Palestine between January and October 2025 using snowball sampling via social media platforms. Data were collected with a structured questionnaire adapted from a validated Malaysian tool and culturally tailored to the Palestinian context. The survey assessed sociodemographic characteristics, KSD knowledge, awareness of prevention, and dietary and lifestyle practices. Descriptive statistics, chi(2) tests, t-tests/ANOVA, Pearson correlation, and multivariable linear and logistic regression were used.Methods RESULTS: Participants were predominantly young (median 19 years) and female (81.2%). The mean knowledge score was 3.16 +/- 1.74 out of six, indicating moderate understanding. While 94.1% had heard of kidney stones, only 56.3% had heard about ways to prevent them, and detailed knowledge of risk factors such as dehydration, high dietary salt, and animal protein intake was limited. Educational attainment independently predicted higher knowledge (p < 0.001), whereas gender, income, and family history were not significant predictors. A weak but statistically significant positive correlation was observed between knowledge score and a composite healthy-lifestyle index (r = 0.21, p < 0.01), suggesting that greater knowledge is associated with, but does not fully determine, healthier behaviors. CONCLUSION: Among this predominantly young, educated online sample, general awareness of kidney stones was high but comprehensive preventive knowledge and some lifestyle practices remained suboptimal. Given the modest link between knowledge and behavior, public health strategies in Palestine should combine clear educational messages on hydration and diet with practical, culturally appropriate support to address behavioral and structural barriers. Integrating KSD prevention into primary care counseling, school health programs, and community campaigns may help reduce the future burden of kidney stone disease. FAU - Deeb, Salahaldeen AU - Deeb S AUID- ORCID: 0000-0001-6299-0925 AD - Faculty of Medicine, Al-Quds University, Jerusalem, Palestine. salahdeeb2001@gmail.com. FAU - Amro, Alhareth M AU - Amro AM AUID- ORCID: 0009-0004-7453-0319 AD - Faculty of Medicine, Al-Quds University, Jerusalem, Palestine. FAU - Deeb, Tasneem Z AU - Deeb TZ AUID- ORCID: 0009-0004-8430-5975 AD - Faculty of Medicine, Al-Quds University, Jerusalem, Palestine. FAU - Zoabi, Ayshe M AU - Zoabi AM AUID- ORCID: 0009-0004-6634-2422 AD - Faculty of Medicine, Al-Quds University, Jerusalem, Palestine. FAU - Amer, Sadeen F AU - Amer SF AUID- ORCID: 0009-0006-2019-5206 AD - Faculty of Medicine, Arab American University, Ramallah, Palestine. FAU - Al-Muhtaseb, Deema N AU - Al-Muhtaseb DN AUID- ORCID: 0009-0005-0168-2490 AD - Faculty of Medicine, Al-Quds University, Jerusalem, Palestine. FAU - Al Haddad, Taima Z AU - Al Haddad TZ AUID- ORCID: 0009-0004-1744-6372 AD - Faculty of Medicine, Hebron University, Hebron, Palestine. FAU - Deeb, Mayar Z AU - Deeb MZ AUID- ORCID: 0009-0003-2174-9897 AD - Faculty of Medicine, Al-Quds University, Jerusalem, Palestine. FAU - Al Qasrawi, Dareen A AU - Al Qasrawi DA AUID- ORCID: 0009-0000-0783-9798 AD - Faculty of Medicine, Palestine Polytechnic University, Hebron, Palestine. FAU - Khanfar, Ahmad H AU - Khanfar AH AUID- ORCID: 0009-0008-9660-2220 AD - Faculty of Medicine, Arab American University, Ramallah, Palestine. LA - eng PT - Journal Article DEP - 20260102 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Male MH - *Health Knowledge, Attitudes, Practice/ethnology MH - *Kidney Calculi/prevention & control MH - Adult MH - *Arabs/statistics & numerical data/psychology MH - Young Adult MH - Surveys and Questionnaires MH - Middle Aged MH - Adolescent MH - Risk Factors PMC - PMC12866439 OTO - NOTNLM OT - Cross-sectional study OT - Kidney stone disease OT - Lifestyle practices OT - Palestine OT - Prevention OT - Public awareness OT - Urolithiasis COIS- Declarations. Ethics approval and consent to participate: All procedures involving human participants complied with the ethical standards of the Institutional Review Board Committee of Al-Quds University, Jerusalem, Palestine (471/REC/2025), and with the 1964 Helsinki declaration and its later amendments. Ethical approval was obtained from the Institutional Review Board Committee of Al-Quds University prior to data collection. Electronic informed consent was obtained from all participants before they accessed the questionnaire. No identifying information was collected, and participation was voluntary. Consent for publication: Not applicable; the manuscript contains no individual person's data. Competing interests: The authors declare no competing interests. Clinical trial number: Not applicable. EDAT- 2026/01/04 06:35 MHDA- 2026/06/27 06:45 PMCR- 2026/01/02 CRDT- 2026/01/04 03:03 PHST- 2025/11/09 00:00 [received] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/06/27 06:45 [medline] PHST- 2026/01/04 06:35 [pubmed] PHST- 2026/01/04 03:03 [entrez] PHST- 2026/01/02 00:00 [pmc-release] AID - 10.1186/s12889-025-26098-2 [pii] AID - 26098 [pii] AID - 10.1186/s12889-025-26098-2 [doi] PST - epublish SO - BMC Public Health. 2026 Jan 2;26(1):425. doi: 10.1186/s12889-025-26098-2. PMID- 41484916 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260730 IS - 1746-4358 (Electronic) IS - 1746-4358 (Linking) VI - 21 IP - 1 DP - 2026 Jan 3 TI - NICU nurses' knowledge, attitudes, practices, and influencing factors regarding breastfeeding of newborns: a scoping review. PG - 14 LID - 10.1186/s13006-025-00807-4 [doi] LID - 14 AB - BACKGROUND: Improved survival rates of high-risk neonates have been accompanied by persistent challenges in breastfeeding support within Neonatal Intensive Care Unit settings. While the World Health Organization strongly advocates for breastfeeding, global breastfeeding rates in NICUs remains suboptimal. NICU nurses play a key role in breastfeeding support, yet their knowledge, attitudes, and practices (KAP) remain systematically underexplored. This study aims to assess NICU nurses' current levels of breastfeeding-related KAP and explore influencing factors, thereby identifying key intervention areas and providing evidence for targeted interventions and training programs. METHODS: This scoping review followed the Arksey and O'Malley framework and systematically searched Medline (Ovid), Embase (Ovid), Web of Science, Scopus, and CINAHL for studies published up to 6 April 2025. Studies were screened using predefined inclusion and exclusion criteria. Data were extracted and synthesized, focusing on NICU nurses' breastfeeding-related knowledge, attitudes, practices, and influencing factors. RESULTS: Fourteen studies across nine countries were ultimately included. NICU nurses generally acknowledged the benefits of breastfeeding and maintained positive attitudes, particularly those who had received breastfeeding training. However, their professional knowledge was notably insufficient, particularly regarding lactation physiology and contraindications to breastfeeding. Consequently, positive attitudes did not consistently translate into standardized clinical practice, with notable variability in implementation and heavy reliance on personal experience. These knowledge-attitude-practice gaps were influenced by multiple factors operating at individual, institutional, and family levels. Furthermore, the assessment of KAP revealed significant methodological challenges, as the included studies used highly heterogeneous assessment tools, often self-designed or adapted, highlighting a lack of standardized KAP instruments tailored to NICU settings. CONCLUSIONS: This review reveals a critical knowledge-attitude-practice gap in NICU breastfeeding support. While nurses' attitudes are positive, their knowledge is deficient and practices inconsistent, a discordance driven by individual, institutional, and methodological challenges. Bridging this gap requires a multi-pronged strategy focused on competency-based training, supportive policies, and the development of validated, NICU-specific assessment tools. FAU - Peng, Hanmei AU - Peng H AD - Department of Nursing, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, 610041, China. AD - Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. FAU - Li, Xia AU - Li X AD - Department of Nursing, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, 610041, China. AD - Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. FAU - Guo, Xuemei AU - Guo X AD - Department of Nursing, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, 610041, China. AD - Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. FAU - Li, Ying-Xin AU - Li YX AD - Department of Nursing, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, 610041, China. AD - Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. FAU - Huang, Xi AU - Huang X AD - Department of Nursing, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, 610041, China. AD - Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. FAU - Zeng, Liangni AU - Zeng L AD - Department of Nursing, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, 610041, China. AD - Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. FAU - Liu, Chengmei AU - Liu C AD - Department of Nursing, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, 610041, China. AD - Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. FAU - Li, Yuan AU - Li Y AD - Department of Nursing, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, 610041, China. li.yuan@scu.edu.cn. AD - Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu, China. li.yuan@scu.edu.cn. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. li.yuan@scu.edu.cn. FAU - Hu, Yanling AU - Hu Y AD - Department of Nursing, West China Second University Hospital, Sichuan University, No. 20, Section 3, South Renmin Road, Chengdu, 610041, China. huyanling0725@scu.edu.cn. AD - Department of Neonatology, West China Second University Hospital, Sichuan University, Chengdu, China. huyanling0725@scu.edu.cn. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. huyanling0725@scu.edu.cn. LA - eng GR - GLYJ2025-12/2025 Hospital Management Research Project of West China Second University Hospital/ GR - H23020/Sichuan Province Nursing Association/ GR - Q2024011/Sichuan Medical Association/ GR - 2024-YF05-00503-SN/Chengdu Science and Technology Bureau/ PT - Journal Article PT - Scoping Review DEP - 20260103 PL - England TA - Int Breastfeed J JT - International breastfeeding journal JID - 101251562 SB - IM MH - Humans MH - *Breast Feeding/psychology MH - *Health Knowledge, Attitudes, Practice MH - Infant, Newborn MH - Female MH - Intensive Care Units, Neonatal MH - *Nurses, Neonatal/psychology MH - Attitude of Health Personnel MH - *Neonatal Nursing PMC - PMC12866404 OTO - NOTNLM OT - Attitudes OT - Breastfeeding OT - Knowledge OT - Neonatal intensive care OT - Nurses OT - Practices OT - Scoping review COIS- Declarations. Human ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/04 06:36 MHDA- 2026/06/28 00:36 PMCR- 2026/01/03 CRDT- 2026/01/04 02:32 PHST- 2025/08/30 00:00 [received] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/06/28 00:36 [medline] PHST- 2026/01/04 06:36 [pubmed] PHST- 2026/01/04 02:32 [entrez] PHST- 2026/01/03 00:00 [pmc-release] AID - 10.1186/s13006-025-00807-4 [pii] AID - 807 [pii] AID - 10.1186/s13006-025-00807-4 [doi] PST - epublish SO - Int Breastfeed J. 2026 Jan 3;21(1):14. doi: 10.1186/s13006-025-00807-4. PMID- 41484877 OWN - NLM STAT- MEDLINE DCOM- 20261005 LR - 20261005 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2026 Jan 3 TI - The mediating and moderating roles of physical sub-health in the relationship between family functioning and mental health problems among Chinese adolescents. PG - 430 LID - 10.1186/s12889-025-26094-6 [doi] LID - 430 AB - BACKGROUND: Adolescent mental health is shaped by both family environments and physical well-being. However, the role of physical sub-health, a state of functional imbalance and fatigue prior to diagnosable illness, remains poorly understood in this process. This study examined whether physical sub-health serves both as a psychosomatic pathway and as a vulnerability factor linking family functioning to adolescent mental health. METHODS: A cross-sectional survey was conducted among 647 primary and secondary school students across China. Validated scales were used to assess family functioning, physical sub-health (operationalized based on constitution characteristics), and mental health symptoms. Structural equation modeling (SEM) was employed to examine the mediating role of physical sub-health. Furthermore, latent moderated structural equation modeling (LMS) was applied to test its moderating effect. RESULTS: Physical sub-health significantly mediated the association between family functioning and mental health, with the largest indirect effects observed for qi stagnation (beta = -0.27, 95% CI [-0.36, -0.20]), qi deficiency (beta = -0.13, 95% CI [-0.17, -0.10]), and phlegm dampness (beta = -0.12, 95% CI [-0.15, -0.08]). These findings suggest that functional bodily imbalance may help explain how family stress is related to emotional and behavioral difficulties. In addition, physical sub-health moderated this association, with adolescents showing poorer physical resilience being more susceptible to the detrimental effects of dysfunctional family environments. CONCLUSION: Physical sub-health plays a dual psychosomatic role in how family functioning relates to adolescent mental well-being, acting as both a mechanism and a vulnerability factor. These findings highlight the potential value of integrated public health strategies that combine family support, school-based identification of psychosomatic risk, and routine health promotion to strengthen youth psychosomatic resilience. TRIAL REGISTRATION: The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board (or Ethics Committee) of Ethics Committee of Beijing University of Chinese Medicine (protocol code No: 2023BZYLL1101 and date of approval: 2023.11.10). FAU - Zhang, Yunan AU - Zhang Y AD - School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China. FAU - Cai, Xuanyi AU - Cai X AD - School of Management, Beijing University of Chinese Medicine, Beijing, 102488, China. FAU - Jiang, Guangxiang AU - Jiang G AD - School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China. FAU - Xu, Wenjie AU - Xu W AD - School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China. FAU - Ran, Yu AU - Ran Y AD - School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China. FAU - Han, Dongran AU - Han D AD - School of Life Sciences, Beijing University of Chinese Medicine, Beijing, 102488, China. handongr@gmail.com. AD - School of Management, Beijing University of Chinese Medicine, Beijing, 102488, China. handongr@gmail.com. FAU - Wen, Hongjuan AU - Wen H AD - School of Management, Changchun University of Traditional Chinese Medicine, Changchun, 130117, China. wenhj@ccucm.edu.cn. FAU - Liu, Yixing AU - Liu Y AD - School of Management, Beijing University of Chinese Medicine, Beijing, 102488, China. yixingliu1987@gmail.com. LA - eng GR - 82205315/National Natural Science Foundation of China (NSFC) Youth Project/ GR - 2022-JYB-JBZR-021/Beijing University of Chinese Medicine/ PT - Journal Article DEP - 20260103 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - Chinese people SB - IM MH - Cross-Sectional Studies MH - *East Asian People/psychology/statistics & numerical data MH - *Family Relations/psychology MH - *Mental Disorders/epidemiology/etiology MH - China/epidemiology MH - Mental Health/ethnology MH - *Adolescent Health MH - *Body Constitution MH - Qi MH - Yin Deficiency/complications/epidemiology/psychology MH - Yang Deficiency/complications/epidemiology/psychology MH - Mediation Analysis MH - Humans MH - Male MH - Female MH - Adolescent MH - Eating PMC - PMC12866022 OTO - NOTNLM OT - Adolescents OT - Family functioning OT - Mediation model OT - Mental health problems OT - Moderation model OT - Physical sub-health COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki and approved by the Institutional Review Board (or Ethics Committee) of Ethics Committee of Beijing University of Chinese Medicine (protocol code No: 2023BZYLL1101 and date of approval: 2023.11.10). Written informed consent was obtained from all participants. For participants under 18 years of age, written informed consent was obtained from a parent/legal guardian, and assent (or electronic informed consent, as applicable) was obtained from the adolescents prior to participation. Participation was entirely voluntary, and adolescents and their guardians were informed that they could withdraw from the study at any time without any negative consequences. All procedures were conducted in accordance with relevant guidelines and regulations (e.g., the Declaration of Helsinki). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/04 06:36 MHDA- 2026/06/27 12:38 PMCR- 2026/01/03 CRDT- 2026/01/04 02:23 PHST- 2025/10/21 00:00 [received] PHST- 2025/12/22 00:00 [accepted] PHST- 2026/06/27 12:38 [medline] PHST- 2026/01/04 06:36 [pubmed] PHST- 2026/01/04 02:23 [entrez] PHST- 2026/01/03 00:00 [pmc-release] AID - 10.1186/s12889-025-26094-6 [pii] AID - 26094 [pii] AID - 10.1186/s12889-025-26094-6 [doi] PST - epublish SO - BMC Public Health. 2026 Jan 3;26(1):430. doi: 10.1186/s12889-025-26094-6. PMID- 41484782 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260702 IS - 1746-4358 (Electronic) IS - 1746-4358 (Linking) VI - 21 IP - 1 DP - 2026 Jan 2 TI - Poor agreement between methods used in population studies to estimate the volume of human milk consumed: a Bland-Altman analysis. PG - 19 LID - 10.1186/s13006-025-00786-6 [doi] LID - 19 AB - BACKGROUND: Measuring the volume of human milk consumed by infants is essential for understanding infant feeding patterns, and their impact on long-term nutrition and health. The study aimed to evaluate the agreement and quantify biases among three methods used to quantify the volume of human milk among children on partial breastfeeding up to 33 months of age. METHODS: A cross-sectional, observational study was conducted between November and December 2022, with socially vulnerable children in the Federal District, Brazil. Dietary intake was assessed using two non-consecutive 24-hour recalls. Human milk volume was estimated using three methods: age/dose-to-mother (DTM), age/partial feeding, and age/feeding. Pearson's correlation coefficient was used to assess associations between methods. Bland-Altman analysis was applied to evaluate agreement between estimates by each method. Statistical significance was set at 5%. RESULTS: Eighty children were evaluated (mean age of 19 months; SD = 6.12), including 15 aged 7-12 months, and 65 aged 13-33 months. Among children aged 7-12 months, moderate and statistically significant correlations were observed between age/DTM x age/partial feeding (r = 0.544, p = 0.02) and between age/partial feeding x age/feeding (r = 0.649, p = < 0.001). The correlation between age/DTM and age/feeding was weak and not statistically significant (r = 0.309, p = 0.097). Most individual estimates fell within the limits of agreement. However, the age/DTM method yielded higher estimated of human milk volume - mean of 321 g/day (95% CI 273, 368) and 333 g/day (95% CI 273, 393) more than the age/feeding and age/partial feeding, respectively. The agreement between methods decreased as estimated milk volume increased. CONCLUSIONS: Although moderate positive correlations were observed among the methods, the age/partial feeding and age/feeding approaches demonstrated the highest level of agreement. No consistent agreement was found between the age/DTM method and the other two approaches. FAU - Lima Cavalcanti, Amanda de Araujo AU - Lima Cavalcanti AA AD - Graduate Program in Human Nutrition, University of Brasilia, Federal District, Brasilia, Brazil. amandanutri06@gmail.com. FAU - Goncalves, Vivian Siqueira Santos AU - Goncalves VSS AD - Graduate Program in Public Health, University of Brasilia, Federal District, Brasilia, Brazil. FAU - Pizato, Nathalia AU - Pizato N AD - Graduate Program in Human Nutrition, University of Brasilia, Federal District, Brasilia, Brazil. AD - Department of Nutrition, Faculty of Health Sciences, University of Brasilia, Federal District, Brasilia, Brazil. FAU - Patriota, Erika Soares de Oliveira AU - Patriota ESO AD - Graduate Program in Public Health, University of Brasilia, Federal District, Brasilia, Brazil. FAU - Guimaraes, Beatriz de Andrade E AU - Guimaraes BAE AD - Department of Nutrition, Faculty of Health Sciences, University of Brasilia, Federal District, Brasilia, Brazil. FAU - Coutinho, Isabela Mendes AU - Coutinho IM AD - Department of Nutrition, Faculty of Health Sciences, University of Brasilia, Federal District, Brasilia, Brazil. FAU - da Costa, Teresa Helena Macedo AU - da Costa THM AD - Graduate Program in Human Nutrition, University of Brasilia, Federal District, Brasilia, Brazil. AD - Department of Nutrition, Faculty of Health Sciences, University of Brasilia, Federal District, Brasilia, Brazil. LA - eng PT - Journal Article PT - Observational Study DEP - 20260102 PL - England TA - Int Breastfeed J JT - International breastfeeding journal JID - 101251562 SB - IM MH - Humans MH - *Milk, Human MH - Infant MH - Female MH - Brazil MH - Cross-Sectional Studies MH - *Breast Feeding/statistics & numerical data MH - Child, Preschool MH - Male PMC - PMC12895698 OTO - NOTNLM OT - Breastfeeding OT - Human milk OT - Intake recall OT - Lactation OT - Stable isotopes COIS- Declarations. Ethical approval: The project was approved by the Ethics and Research Committee of the Faculty of Health Sciences of the University of Brasilia (UnB) (CAAE: 32390620.0.0000.0030), and the children's guardians signed the Free and Informed Consent Form (FICF) before the start of data collection. Competing interests: The authors declare no competing interests. EDAT- 2026/01/04 06:36 MHDA- 2026/06/27 06:43 PMCR- 2026/01/02 CRDT- 2026/01/04 02:00 PHST- 2025/07/26 00:00 [received] PHST- 2025/11/11 00:00 [accepted] PHST- 2026/06/27 06:43 [medline] PHST- 2026/01/04 06:36 [pubmed] PHST- 2026/01/04 02:00 [entrez] PHST- 2026/01/02 00:00 [pmc-release] AID - 10.1186/s13006-025-00786-6 [pii] AID - 786 [pii] AID - 10.1186/s13006-025-00786-6 [doi] PST - epublish SO - Int Breastfeed J. 2026 Jan 2;21(1):19. doi: 10.1186/s13006-025-00786-6. PMID- 41484781 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260626 IS - 2052-1847 (Print) IS - 2052-1847 (Electronic) IS - 2052-1847 (Linking) VI - 18 IP - 1 DP - 2026 Jan 3 TI - Feasibility and physical health outcomes of a 1-year sport-based physical activity intervention in rural middle school children. PG - 56 LID - 10.1186/s13102-025-01498-4 [doi] LID - 56 AB - BACKGROUND/OBJECTIVE: Rural children face challenges to participating in physical activity (PA). These barriers include lack of facilities, adequate equipment, trained personnel, and transportation limitations. The primary objective of this study was to evaluate intervention feasibility, particularly focusing on the trial- and intervention-related indicators. The secondary objective was to assess preliminary efficacy and outcome trends in accelerometer-collected PA data from pre-, mid-, to post-intervention, as well as changes in physical measures (i.e., maximum plank test, 6-minute walk test). METHODS: We conducted a 1-year controlled cohort study of 83 6th-8th grade children attending an under-resourced rural middle school in the Midwestern United States. The intervention, Hoosier Sport, was implemented by trained college students in an undergraduate service-learning course. The test group participated in enhanced PE classes including various sports and positive youth development lessons. The control group participated in standard health class curriculum. The primary outcomes were trial- and intervention-related feasibility indicators for children and college student implementers. The measures included AIM (Acceptability of Intervention Measure), IAM (Intervention Appropriateness Measure), and FIM (Feasibility of Intervention Measure), as well as recruitment and retention. Secondary outcomes included light, moderate, vigorous, and total PA, self-reported weekly PA, a maximum plank test, and 6-minute walk test. Given the repeated measures design at three time points (pre-, mid-, and post-intervention) and our primary interest in detecting within-subject changes and between-group differences, analysis focused on linear mixed models with within-between interaction effects. RESULTS: FIM (median = 17), AIM (median = 18), and IAM (median = 17) scores exceeded the success threshold (median > 16) when assessed at post-intervention. Total minutes of PA decreased from baseline to mid (beta = -42.762, 95% CI(-101.220, 15.696)) and baseline to post (beta = -35.952, 95% CI(-89.617, 17.713)), but neither difference was significant (p = 0.149 & 0.185, respectively). At baseline, the test group estimated 64.91 more total minutes of PA than the control group (t(101.13) = 1.82, p = 0.072, dz = 0.771), with a marginally significant difference. There were no significant differences in change over time of total or self-reported PA between the groups (p > 0.05). CONCLUSIONS: The 1-year intervention was feasible to implement, with high appropriateness and acceptability among rural middle school children. Refinements are needed to continue targeting improvements in children's PA. TRIAL REGISTRATION: ClinicalTrials.gov ID: NCT06602596 Registration Date: 09.17.2024. FAU - Callahan, Sydney H AU - Callahan SH AD - Department of Kinesiology, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA. FAU - King, Julianna F AU - King JF AD - Department of Kinesiology, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA. AD - Department of Applied Health Science, School of Public Health- Bloomington, Indiana University, Bloomington, IN, USA. FAU - Ortyl, Bailey K AU - Ortyl BK AD - Department of Epidemiology and Biostatistics, School of Public Health- Bloomington, Indiana University, Bloomington, IN, USA. FAU - Cumming, Noah G AU - Cumming NG AD - Department of Kinesiology, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA. FAU - Watkins, Janette M AU - Watkins JM AD - Department of Kinesiology, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA. FAU - Goss, Janelle M AU - Goss JM AD - Department of Kinesiology, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA. FAU - Martinez Kercher, Vanessa M AU - Martinez Kercher VM AD - Department of Health & Wellness Design, School of Public Health- Bloomington, Indiana University, Bloomington, IN, USA. FAU - Kercher, Kyle A AU - Kercher KA AD - Department of Kinesiology, School of Public Health-Bloomington, Indiana University, Bloomington, IN, USA. kylkerch@iu.edu. LA - eng SI - ClinicalTrials.gov/NCT06602596 GR - 24CDA1038890/American Heart Association/ PT - Journal Article DEP - 20260103 PL - England TA - BMC Sports Sci Med Rehabil JT - BMC sports science, medicine & rehabilitation JID - 101605016 PMC - PMC12866409 OTO - NOTNLM OT - Positive youth development OT - School-based intervention OT - Service-learning OT - Sport participation OT - Sport-based youth development COIS- Declarations. Ethics approval and consent to participate: The Indiana University Institutional Review Board approved the study protocol (#23985). The participants provided their informed consent/assent prior to participating in the study. An informed consent form was signed by each parent/legal guardian, and the protocol of this study was in accordance with the guidelines of the Declaration of Helsinki. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2026/01/04 06:35 MHDA- 2026/01/04 06:36 PMCR- 2026/01/03 CRDT- 2026/01/04 02:00 PHST- 2025/10/06 00:00 [received] PHST- 2025/12/15 00:00 [accepted] PHST- 2026/01/04 06:36 [medline] PHST- 2026/01/04 06:35 [pubmed] PHST- 2026/01/04 02:00 [entrez] PHST- 2026/01/03 00:00 [pmc-release] AID - 10.1186/s13102-025-01498-4 [pii] AID - 1498 [pii] AID - 10.1186/s13102-025-01498-4 [doi] PST - epublish SO - BMC Sports Sci Med Rehabil. 2026 Jan 3;18(1):56. doi: 10.1186/s13102-025-01498-4. PMID- 41482617 OWN - NLM STAT- MEDLINE DCOM- 20260102 LR - 20260102 IS - 1815-7920 (Electronic) IS - 1027-3719 (Linking) VI - 30 IP - 1 DP - 2026 Jan 2 TI - Factors associated with pulmonary TB in malnourished children admitted to rehabilitation centres. PG - 21-26 LID - 10.5588/ijtld.25.0338 [doi] AB - OBJECTIVESPrimary objective of the study was to identify TB-associated factors in admitted malnourished children at malnutrition treatment centres, Rajasthan, India.DESIGNA nested case-control study was conducted. Clinical and demographic data were analysed. Crude and adjusted odds ratios were calculated.RESULTSThe study included 39 confirmed TB cases and 512 controls. A total of 20 clinical factors were analysed. Bivariate analysis identified three statistically significantly associated factors. These were 1) cough duration of >/=2 weeks (odds ratio [OR] = 5.4; 95% confidence interval [CI]: 2.5-11.6), 2) fever duration of >/=2 weeks (OR = 3.3; 95% CI: 1.4-7.7), and 3) Mantoux test >/= 5 mm (OR = 4.4; 95% CI: 1.4-14.2). Multivariate regression analysis revealed that 1) cough duration of >/=2 weeks (adjusted odds ratio [AOR] = 4.2; 95% CI: 1.5-11.7) and 2) hepatomegaly (AOR = 2.4; 95% CI: 1.01-5.5) were independently and significantly associated with TB.CONCLUSIONStudy findings align with paediatric TB diagnostic criteria, which emphasise persistent cough >/=2 weeks as an important criterion of presumptive TB. However, hepatomegaly came out as a new, independently significant associated factor. A study with large number of cases may be undertaken to validate the association of hepatomegaly.. FAU - Anand, P K AU - Anand PK AD - ICMR - National Institute for Implementation Research on Non-communicable Diseases, Jodhpur, India. FAU - Patel, D AU - Patel D AD - ICMR - National Institute for Implementation Research on Non-communicable Diseases, Jodhpur, India;, Indian Institute of Public Health, Gandhi Nagar, India. FAU - Lata, S AU - Lata S AD - Department of Pathology, Dr Sampoornanand Medical College, Jodhpur, India. FAU - Gautam, J K AU - Gautam JK AD - ICMR - National Institute for Implementation Research on Non-communicable Diseases, Jodhpur, India. FAU - Chaudhary, M AU - Chaudhary M AD - Community Health Centre, State Health Department, Government of Rajasthan, Phalodi, India. FAU - Singh, M AU - Singh M AD - Indian Council of Medical Research, New Delhi, India. FAU - Soni, P AU - Soni P AD - State Tuberculosis Office, State Health Department, Government of Rajasthan, Jaipur, India. FAU - Kabra, S K AU - Kabra SK AD - Department of Pediatrics, All India Institute of Medical Sciences, New Delhi, India. FAU - Babu, B V AU - Babu BV AD - ICMR - National Institute for Implementation Research on Non-communicable Diseases, Jodhpur, India. LA - eng PT - Journal Article PL - France TA - Int J Tuberc Lung Dis JT - The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease JID - 9706389 SB - IM MH - Humans MH - Male MH - Female MH - Case-Control Studies MH - India/epidemiology MH - *Tuberculosis, Pulmonary/epidemiology/diagnosis MH - Child, Preschool MH - Infant MH - Cough/epidemiology MH - Risk Factors MH - Rehabilitation Centers MH - Child MH - Fever/epidemiology MH - *Child Nutrition Disorders/epidemiology/complications MH - *Malnutrition/epidemiology/complications MH - Tuberculin Test MH - Multivariate Analysis MH - Odds Ratio MH - Time Factors EDAT- 2026/01/03 00:30 MHDA- 2026/01/03 00:31 CRDT- 2026/01/02 23:33 PHST- 2026/01/03 00:31 [medline] PHST- 2026/01/03 00:30 [pubmed] PHST- 2026/01/02 23:33 [entrez] AID - 10.5588/ijtld.25.0338 [doi] PST - ppublish SO - Int J Tuberc Lung Dis. 2026 Jan 2;30(1):21-26. doi: 10.5588/ijtld.25.0338. PMID- 41482015 OWN - NLM STAT- MEDLINE DCOM- 20260321 LR - 20260321 IS - 2212-2672 (Print) IS - 2212-2672 (Linking) VI - 126 IP - 4 DP - 2026 Apr TI - Rationale and Study Protocol for the Academy of Nutrition and Dietetics' Breastfeeding Registry Study. PG - 156285 LID - S2212-2672(25)00895-0 [pii] LID - 10.1016/j.jand.2025.156285 [doi] AB - BACKGROUND: Breastfeeding can improve public health and reduce the economic burden associated with illness, hospitalization, and mortality of infants and mothers. Despite the potential for registered dietitian nutritionists (RDNs) to contribute to this area of practice, there are no studies that have analyzed the influence of RDNs on breastfeeding-related health outcomes, such as breastfeeding duration. OBJECTIVE: The Breastfeeding Registry study aims to describe the nutrition care and health-related outcomes of breastfeeding infants receiving care from RDNs. DESIGN: This is a pilot prospective cohort registry study. PARTICIPANTS: Participants are breastfeeding infants receiving care from RDNs as well as RDNs providing care to enrolled infants. DATA COLLECTION: RDNs will provide usual care and document for up to 6 months in an electronic Nutrition Care Process database (the Academy of Nutrition and Dietetics Health Informatics Infrastructure). The validated Nutrition Care Process-Quality Evaluation and Standardization Tool will assess documentation quality. RDNs will document initial and follow-up encounters for infants, aiming to analyze documentation from at least 60 infants. RDNs will be surveyed on site characteristics, individual education, training, and professional experience to account for possible confounding. MAIN OUTCOME MEASURES: The primary health outcome is breastfeeding duration. Secondary outcomes include the frequencies of NCP Terminology documented by NCP step, documentation quality, and rates of nutrition diagnosis resolution and goal attainment. Using the NCP framework, complete NCP cycles that demonstrate improvement in the most prevalent nutrition problems (defined as impactful care plans) will also be presented. ISSUES: Recruitment challenges and large variability in tracked indicators are anticipated, as is common in registry studies. Training and documentation requirements may limit enrollment. CI - Copyright (c) 2026 Academy of Nutrition and Dietetics. Published by Elsevier Inc. All rights reserved. FAU - Gaubert, Allison C AU - Gaubert AC AD - Nicholls State University, Thibodaux, Louisiana. FAU - Long, Julie M AU - Long JM AD - Academy of Nutrition and Dietetics, Chicago, Illinois. FAU - Woodcock, Lindsay AU - Woodcock L AD - Academy of Nutrition and Dietetics, Chicago, Illinois. FAU - Colin, Casey R AU - Colin CR AD - Brooks College of Health, University of North Florida, Jacksonville, Florida. FAU - Wright, Lauri AU - Wright L AD - College of Public Health, University of South Florida, Tampa, Florida. FAU - Hamadi, Hanadi AU - Hamadi H AD - Brooks College of Health, University of North Florida, Jacksonville, Florida. FAU - Papoutsakis, Constantina AU - Papoutsakis C AD - Academy of Nutrition and Dietetics, Chicago, Illinois. Electronic address: cpapoutsakis@eatright.org. LA - eng PT - Journal Article DEP - 20251231 PL - United States TA - J Acad Nutr Diet JT - Journal of the Academy of Nutrition and Dietetics JID - 101573920 SB - IM MH - Humans MH - *Breast Feeding/statistics & numerical data MH - *Registries MH - *Dietetics/methods MH - Prospective Studies MH - *Nutritionists MH - Pilot Projects MH - Infant MH - Female MH - Academies and Institutes MH - Infant, Newborn MH - Research Design EDAT- 2026/01/03 00:30 MHDA- 2026/03/22 06:07 CRDT- 2026/01/02 19:25 PHST- 2024/09/20 00:00 [received] PHST- 2025/12/11 00:00 [revised] PHST- 2025/12/24 00:00 [accepted] PHST- 2026/03/22 06:07 [medline] PHST- 2026/01/03 00:30 [pubmed] PHST- 2026/01/02 19:25 [entrez] AID - S2212-2672(25)00895-0 [pii] AID - 10.1016/j.jand.2025.156285 [doi] PST - ppublish SO - J Acad Nutr Diet. 2026 Apr;126(4):156285. doi: 10.1016/j.jand.2025.156285. Epub 2025 Dec 31. PMID- 41480193 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260102 LR - 20260104 IS - 2472-1972 (Electronic) IS - 2472-1972 (Linking) VI - 10 IP - 1 DP - 2026 Jan TI - Clinically Optimized Adult Height Prediction From Key Bone and Pubertal Stages: Prospective Validation to Adult Height. PG - bvaf201 LID - 10.1210/jendso/bvaf201 [doi] LID - bvaf201 AB - CONTEXT: Accurate adult height prediction remains a challenge in pediatric endocrinology. Traditional bone age (BA) based methods are time-consuming, software-dependent, and unreliable, while ignoring the critical effect of pubertal progression on growth potential. OBJECTIVE: In this work we aimed to develop a clinically optimized model for adult height prediction by replacing traditional BA with key bone grades to quantify growth potential, integrating pubertal stages to account for pubertal-stage growth variations, and establishing a direct mapping between "key bone grades + pubertal stage" and height growth potential. METHODS: A cross-sectional study was conducted in Beijing (2022-2023). We performed Tanner-Whitehouse 3/radius-ulna-short bone grading and pubertal staging including prepuberty, on puberty, and completing puberty. Spearman analysis identified key bone combinations most associated with BA and height. An integrated model combining bone grades and pubertal stage was developed and validated in an independent cohort followed to adult height. RESULTS: Key Spearman correlation revealed strong correlations of the radius, ulna and metacarpal I grading with BA (rho = 0.94-0.96), with bone combinations (rho = 0.98-0.99) outperforming any single bones. Three types of bone combinations (radius + ulna, radius + metacarpal I, and radius + ulna + metacarpal I) integrating with pubertal stages demonstrated approximately equivalent predictive performance for adult height prediction. Considering bone representativeness and feasibility, we prefer to propose the radius + metacarpal I combination with puberty stages as the clinically optimized model for adult height prediction. Independent validation cohort confirmed superior accuracy of the proposed model vs traditional BA-based methods: Mean prediction error was reduced from 0.71 cm to 0.02 cm, while the proportion of predictions error of 3 cm or less increased from 66.9% to 73.5%. CONCLUSION: The integrated bone-puberty model significantly improves prediction accuracy by incorporating skeletal maturity and pubertal dynamics. Its streamlined 2-bone protocol offers a practical tool for growth monitoring and clinical decision-making. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of the Endocrine Society. FAU - Wu, Huahong AU - Wu H AUID- ORCID: 0000-0001-6979-2980 AD - Department of Growth and Development, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Zhang, Yaqin AU - Zhang Y AD - Department of Growth and Development, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Yu, Chengdong AU - Yu C AD - Department of Growth and Development, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Li, Yang AU - Li Y AD - Department of Endocrinology, Genetics and Metabolism, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing 100020, China. FAU - Shu, Wen AU - Shu W AD - Department of Growth and Development, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Li, Tao AU - Li T AD - Child Health Big Data Research Center, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Huang, Guimin AU - Huang G AD - Child Health Big Data Research Center, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Hou, Dongqing AU - Hou D AD - Child Health Big Data Research Center, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Chen, Fangfang AU - Chen F AD - Department of Epidemiology, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Liu, Junting AU - Liu J AD - Child Health Big Data Research Center, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Li, Shaoli AU - Li S AD - Child Health Big Data Research Center, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. FAU - Zong, Xin'nan AU - Zong X AUID- ORCID: 0000-0002-9465-9230 AD - Department of Growth and Development, Capital Center for Children's Health, Capital Medical University, Capital Institute of Pediatrics, Beijing 100020, China. LA - eng PT - Journal Article DEP - 20251210 PL - United States TA - J Endocr Soc JT - Journal of the Endocrine Society JID - 101697997 PMC - PMC12754412 OTO - NOTNLM OT - integrated model OT - key bone grade OT - predict adult height OT - pubertal stage EDAT- 2026/01/02 06:29 MHDA- 2026/01/02 06:30 PMCR- 2025/12/10 CRDT- 2026/01/02 04:45 PHST- 2025/10/19 00:00 [received] PHST- 2025/12/02 00:00 [accepted] PHST- 2026/01/02 06:30 [medline] PHST- 2026/01/02 06:29 [pubmed] PHST- 2026/01/02 04:45 [entrez] PHST- 2025/12/10 00:00 [pmc-release] AID - bvaf201 [pii] AID - 10.1210/jendso/bvaf201 [doi] PST - epublish SO - J Endocr Soc. 2025 Dec 10;10(1):bvaf201. doi: 10.1210/jendso/bvaf201. eCollection 2026 Jan. PMID- 41479825 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260102 LR - 20260104 IS - 2220-6124 (Print) IS - 2220-6124 (Electronic) IS - 2220-6124 (Linking) VI - 14 IP - 4 DP - 2025 Dec 25 TI - Risk factors for developing acute kidney injury after heart transplant: A systematic review and meta-analysis. PG - 110791 LID - 10.5527/wjn.v14.i4.110791 [doi] LID - 110791 AB - BACKGROUND: Acute kidney injury (AKI) is a common and serious complication following heart transplantation, significantly impacting patient outcomes and survival rates. AKI after transplantation can lead to prolonged hospital stays, increased morbidity, and even mortality. AIM: To identify and quantify significant risk factors associated with AKI following heart transplantation through a systematic review and meta-analysis. This study aims to distinguish predictive variables that may inform perioperative risk stratification and clinical decision-making. METHODS: Electronic searches on MEDLINE, Google Scholar, ScienceDirect, ClinicalTrials.gov, and Cochrane databases were conducted from inception up till September 1. Included studies were randomized controlled trials, clinical trials, retrospective cohort, and observational studies. Exclusion criteria encompassed studies with pediatric populations, non-English publications, case reports, and studies lacking sufficient data on AKI outcomes. Statistical analysis was performed using RevMan 5.4, reporting dichotomous outcomes as odds ratios (OR) and continuous outcomes as mean differences (MD) with 95% confidence intervals (CI). Quality assessment of the included studies was performed using the New Castle Ottawa Scale. RESULTS: Out of 1345 articles, 13 studies with 3330 patients were included. Significant risk factors included age [overall MD = 2.27 years (95%CI: 0.13 to 4.41)], body mass index (BMI) [MD = 1.42 (95%CI: 0.60 to 2.24)], diabetes [overall OR = 1.47 (95%CI: 1.16 to 1.85)], chronic kidney disease (CKD) [OR = 2.67 (95%CI: 1.73 to 4.14)], chronic obstructive pulmonary disorder (COPD) [OR = 0.49 (95%CI: 0.27 to 0.89)], previous thoracic surgery [(OR) = 1.27, 95%CI: (1.05 to 1.54)], cardio-pulmonary bypass time [(MD) = 17.10, 95%CI: (6.12 to 28.08)], mechanical ventilation duration [(MD) = 30.87 hours, 95%CI: (10.69 to 51.05)] and extracorporeal membrane oxygenation [(OR) = 2.31, 95%CI: (1.25 to 4.26)]. Factors not associated with AKI after heart transplantation included Recipients' male sex (P = 0.55), donor sex (P = 0.11), hypertension (P = 0.13), smoking (P = 0.20), coronary artery disease (P = 0.90), pulmonary artery disease (P = 0.81), dilated cardiomyopathy (P = 0.79), ventilation duration (P = 0.24), ischemic time (P = 0.06), use of intra-aortic balloon pump (P = 0.14), LVAD transplantation (P = 0.83), and Inotropes use (P = 0.78). CONCLUSION: Age, BMI, diabetes, CKD, COPD, previous thoracic surgery, prolonged CPB time, extended mechanical ventilation, and ECMO use are significant predictors of AKI following heart transplantation, necessitating vigilant monitoring and individualized risk assessment. Conversely, factors such as LVAD implantation and inotrope use showed no significant association, highlighting the need for further investigation into their roles. Future prospective studies are essential to validate these findings, elucidate underlying mechanisms, and develop targeted interventions to mitigate AKI risk and improve patient outcomes. CI - (c)The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. FAU - Khawar, Muneeb AU - Khawar M AD - Department of Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan. FAU - Sehar, Ayesha AU - Sehar A AD - Department of Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan. FAU - Shahzad, Manahil AU - Shahzad M AD - Department of Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan. FAU - Farooq, Hasnain AU - Farooq H AD - Department of Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan. FAU - Rehman, Obaid Ur AU - Rehman OU AD - Department of Medicine, Services Institute of Medical Sciences, Lahore 54000, Punjab, Pakistan. FAU - Alvi, Zainab AU - Alvi Z AD - Department of Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan. FAU - Ali, Sheraz AU - Ali S AD - Department of Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan. FAU - Hadeed Khawar, Mirza Muhammad AU - Hadeed Khawar MM AD - Department of Medicine, Services Institute of Medical Sciences, Lahore 54000, Punjab, Pakistan. FAU - Saifullah, Muneeb AU - Saifullah M AD - Department of Medicine, King Edward Medical University, Lahore 54000, Punjab, Pakistan. FAU - Khail, Hamza Aka AU - Khail HA AD - Department of Medicine, Kateb University Faculty of Medicine, Kabul 1006, Kabul, Afghanistan. hamzaakakhail14@gmail.com. FAU - Qadeer, Abdul AU - Qadeer A AD - Department of Medicine, Mayo Clinic Hospital, Phoenix, AZ 85054, United States. FAU - Villanueva, Mark N AU - Villanueva MN AD - Department of Nephrology, Mayo Clinic Hospital, Phoenix, AZ 85054, United States. FAU - Mour, Girish K AU - Mour GK AD - Department of Nephrology, Mayo Clinic Hospital, Phoenix, AZ 85054, United States. LA - eng PT - Journal Article PL - United States TA - World J Nephrol JT - World journal of nephrology JID - 101610229 PMC - PMC12754407 OTO - NOTNLM OT - Acute kidney injury OT - Age OT - Body mass index OT - Cardiac transplantation OT - Chronic kidney disease OT - Diabetes OT - Kidney failure OT - Risk factors COIS- Conflict-of-interest statement: All authors declare that they have no conflict of interest to disclose. EDAT- 2026/01/02 06:29 MHDA- 2026/01/02 06:30 PMCR- 2025/12/25 CRDT- 2026/01/02 04:39 PHST- 2025/06/16 00:00 [received] PHST- 2025/07/04 00:00 [revised] PHST- 2025/09/24 00:00 [accepted] PHST- 2026/01/02 06:30 [medline] PHST- 2026/01/02 06:29 [pubmed] PHST- 2026/01/02 04:39 [entrez] PHST- 2025/12/25 00:00 [pmc-release] AID - 10.5527/wjn.v14.i4.110791 [doi] PST - ppublish SO - World J Nephrol. 2025 Dec 25;14(4):110791. doi: 10.5527/wjn.v14.i4.110791. PMID- 41479161 OWN - NLM STAT- MEDLINE DCOM- 20260129 LR - 20260924 IS - 1744-8417 (Electronic) IS - 1744-6651 (Linking) VI - 21 IP - 1 DP - 2026 Jan TI - Assessing diabetes awareness and health behaviors among adults in Jordan: a national cross-sectional study. PG - 81-88 LID - 10.1080/17446651.2025.2609601 [doi] AB - BACKGROUND: Diabetes mellitus is a major public health challenge in Jordan. This study aimed to assess diabetes awareness and health behaviors among Jordanian adults and identify key sociodemographic predictors of knowledge. RESEARCH DESIGN AND METHODS: A national cross-sectional study was conducted, surveying 1,994 adults via online and in-person interviews. A validated questionnaire assessed diabetes knowledge and health behaviors. Data were analyzed using multivariate regression to identify predictors of knowledge. RESULTS: General diabetes awareness was high (98%), but specific knowledge gaps were identified. Only 52.3% understood glucose tolerance testing, and 38% recognized that diabetes control improves by avoiding smoking. Higher education (Bachelor's: beta = 0.39, p = 0.004; Master's: beta = 0.68, p < 0.001) and healthcare employment (beta = 1.34, p < 0.001) strongly predicted better knowledge. Healthier behaviors like regular exercise (beta = 0.24, p = 0.004) and balanced diets (beta = 0.19, p = 0.001) correlated with higher scores, while smokers scored lower (beta = -0.29, p = 0.002). CONCLUSION: Despite high general awareness, critical gaps persist in diagnostics and lifestyle-related knowledge. Targeted interventions addressing smoking cessation, testing protocols, and culturally tailored education are needed to enhance diabetes management in Jordan. FAU - Tanashat, Mohammad AU - Tanashat M AD - Faculty of Medicine, Yarmouk University, Irbid, Jordan. FAU - Albandak, Maram AU - Albandak M AD - Department of Internal Medcine, The University of Toledo, Toledo, OH, USA. FAU - Fakih, Nour AU - Fakih N AD - School of Dental Medicine, BAU International University Batumi, Batumi, Georgia. FAU - Elettreby, Abdelrahman M AU - Elettreby AM AD - Faculty of Medicine, Mansoura University, Mansoura, Egypt. FAU - Abouzid, Mohamed AU - Abouzid M AUID- ORCID: 0000-0002-8917-671X AD - Department of Physical Pharmacy and Pharmacokinetics, Faculty of Pharmacy, Poznan University of Medical Sciences, Poznan, Poland. FAU - Alwadi, Mu'taz J AU - Alwadi MJ AD - Department of Endocrinology, King Hussein Medical Hospital, Royal Medical Services, Amman, Jordan. FAU - Habboush, Maryam AU - Habboush M AD - Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan. FAU - AlMomani, Hebah AU - AlMomani H AD - Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan. FAU - AlAnanzeh, Samah AU - AlAnanzeh S AD - Department of Pediatrics, Royal Medical Services, Amman, Jordan. FAU - Al Akash, Minnat Allah AU - Al Akash MA AD - Faculty of Medicine, Yarmouk University, Irbid, Jordan. FAU - Kamil, Kamil Ahmad AU - Kamil KA AD - Medical Faculty, Malalay Institute of Higher Education, Kandahar, Afghanistan. FAU - Heilat, Hadeel B AU - Heilat HB AD - Department of Clinical Medical Sciences, Yarmouk University, Irbid, Jordan. LA - eng PT - Journal Article DEP - 20260101 PL - England TA - Expert Rev Endocrinol Metab JT - Expert review of endocrinology & metabolism JID - 101278293 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Jordan/epidemiology MH - Male MH - Female MH - Adult MH - *Health Knowledge, Attitudes, Practice MH - Middle Aged MH - *Health Behavior MH - *Diabetes Mellitus/epidemiology/psychology MH - Surveys and Questionnaires MH - Young Adult MH - Aged MH - Adolescent OTO - NOTNLM OT - Diabetes mellitus OT - Jordan OT - health awareness OT - knowledge gaps OT - lifestyle behaviors OT - public health EDAT- 2026/01/02 06:29 MHDA- 2026/01/29 14:02 CRDT- 2026/01/02 00:53 PHST- 2026/01/29 14:02 [medline] PHST- 2026/01/02 06:29 [pubmed] PHST- 2026/01/02 00:53 [entrez] AID - 10.1080/17446651.2025.2609601 [doi] PST - ppublish SO - Expert Rev Endocrinol Metab. 2026 Jan;21(1):81-88. doi: 10.1080/17446651.2025.2609601. Epub 2026 Jan 1. PMID- 41478747 OWN - NLM STAT- MEDLINE DCOM- 20260212 LR - 20260212 IS - 1590-3729 (Electronic) IS - 0939-4753 (Linking) VI - 36 IP - 3 DP - 2026 Mar TI - Dietary tryptophan intake density and the risk of cardiovascular diseases: insights from a prospective cohort study. PG - 104468 LID - S0939-4753(25)00623-4 [pii] LID - 10.1016/j.numecd.2025.104468 [doi] AB - BACKGROUND AND AIM: Tryptophan's metabolic products, serotonin and melatonin, exhibit antioxidant activity and neuroprotective properties, thereby preventing mortality from cardiovascular diseases (CVD). We aim to examine the relationship between dietary tryptophan intake density and the risk of CVD. METHODS AND RESULTS: A prospective cohort study was conducted in northern Vietnam from 2008 to 2019, which comprises 42,146 participants aged 10 and older. Dietary tryptophan intake density per 1000 kcal was assessed using a validated semi-quantitative food frequency questionnaire. CVD deaths were 348 cases. The mean age was 38.5 years; 48 % were male and 52 % were female. The median follow-up duration was 11.01 years. Hazard ratio and 95 % confidence interval HR (95 % CI) were calculated for the association between dietary tryptophan intake density and mortality risks from CVD. The inverse association between dietary tryptophan intake density, top to bottom quintile, and CVD was seen for the entire study population, HR (95 % CI): 0.59 (0.42, 0.83), and after excluding deaths in the first three years, HR (95 % CI): 0.59 (0.41, 0.86). The results remained after additional adjustment for pack-years of smoking. A similar protective pattern was observed in subgroups with BMI <23 kg/m(2), smokers, drinkers, and men. The beneficial effect was observed in both young adults and those 65 years or older. CONCLUSIONS: A beneficial effect of dietary tryptophan intake density against the risk of CVD was observed. The findings warrant further research to understand the mechanism and its application in preventing CVD. CI - Copyright (c) 2025 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved. FAU - Nguyen, Hieu Lan AU - Nguyen HL AD - Dept. of Cardiology, Hanoi Medical University Hospital, Hanoi Medical University, Hanoi City, Viet Nam. Electronic address: Nguyenlanhieu.muh@gmail.com. FAU - Le, Linh Thuy AU - Le LT AD - Laboratory of Embryology and Genetics of Human Malformation, Imagine Institute, INSERM UMR, Paris City, France. Electronic address: lelinh2611@gmail.com. FAU - Nguyen, Thinh Gia AU - Nguyen TG AD - School of Medicine, International University of Health and Welfare, Narita City, Japan. Electronic address: giathinh7576@gmail.com. FAU - Nguyen, Quynh Thu AU - Nguyen QT AD - Department of Urology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, 807-8555, Japan. Electronic address: quynh@med.uoeh-u.ac.jp. FAU - Nguyen, Hieu Van AU - Nguyen HV AD - Dept. of Cardiology, Hanoi Medical University Hospital, Hanoi Medical University, Hanoi City, Viet Nam. Electronic address: vanhieuyhn@gmail.com. FAU - Le, Ngoan Tran AU - Le NT AD - Department of Clinical Research, Vinmec Healthcare System, Hanoi City, 113-900, Viet Nam; Institute of Research and Development, Duy Tan University, Da Nang City, Viet Nam. Electronic address: letranngoan@duytan.edu.vn. LA - eng PT - Journal Article DEP - 20251120 PL - Netherlands TA - Nutr Metab Cardiovasc Dis JT - Nutrition, metabolism, and cardiovascular diseases : NMCD JID - 9111474 RN - 8DUH1N11BX (Tryptophan) SB - IM MH - Humans MH - Male MH - *Tryptophan/administration & dosage/adverse effects MH - Female MH - Prospective Studies MH - *Cardiovascular Diseases/prevention & control/mortality/diagnosis/epidemiology MH - Adult MH - Middle Aged MH - Protective Factors MH - Risk Assessment MH - Heart Disease Risk Factors MH - Time Factors MH - Young Adult MH - Vietnam/epidemiology MH - Adolescent MH - Child MH - *Diet, Healthy MH - Nutritive Value MH - Aged MH - Prognosis MH - Recommended Dietary Allowances OTO - NOTNLM OT - CVD OT - Dietary tryptophan intake density OT - Epidemiology OT - Prospective cohort study COIS- Conflict of interest The authors declare no competing interests. EDAT- 2026/01/02 00:33 MHDA- 2026/02/13 01:26 CRDT- 2026/01/01 21:57 PHST- 2025/07/22 00:00 [received] PHST- 2025/10/29 00:00 [revised] PHST- 2025/11/07 00:00 [accepted] PHST- 2026/02/13 01:26 [medline] PHST- 2026/01/02 00:33 [pubmed] PHST- 2026/01/01 21:57 [entrez] AID - S0939-4753(25)00623-4 [pii] AID - 10.1016/j.numecd.2025.104468 [doi] PST - ppublish SO - Nutr Metab Cardiovasc Dis. 2026 Mar;36(3):104468. doi: 10.1016/j.numecd.2025.104468. Epub 2025 Nov 20. PMID- 42902622 STAT- Publisher ISBN- 978-92-4-012387-8 ISBN- 978-92-4-012388-5 PB - World Health Organization CTI - WHO Guidelines Approved by the Guidelines Review Committee DP - 2026 BTI - WHO guideline on the integrated management of obesity in adolescents AB - This WHO guideline provides practice- and science-informed global clinical and public health recommendations for the integrated management of obesity in adolescents aged 10-19 years, responding to the growing global burden of obesity and supporting improved case management and care pathways through a primary health care approach. Its aim is to help Member States and their partners adopt and adapt interventions that improve health, functioning and reduce obesity-associated disability. Developed using a people-centred approach, the guideline considers the views, values and preferences of adolescents and their caregivers and is grounded in principles of equity, gender equality and human rights. The guideline presents recommendations on dietary interventions, physical activity, sedentary behaviour and sleep, behaviour changing interventions, digital health interventions, pharmacotherapy, bariatric surgery, and multimodal interventions. The recommendations are informed by systematic evidence reviews together with considerations of benefits and harms, equity, acceptability, feasibility, costs, and the values and preferences of adolescents and their caregivers. Intended for policy-makers, programme managers, health workers and others involved in adolescent obesity care, the guideline also outlines its development methodology, implementation considerations, monitoring approaches and research priorities to support future updates. CI - (c) World Health Organization 2026. LA - eng PT - Practice Guideline PT - Review PT - Book PL - Geneva EDAT- 2026/01/01 00:00 CRDT- 2026/01/01 00:00 AID - NBK625534 [bookaccession] PMID- 42902615 STAT- Publisher ISBN- 978-92-4-012339-7 ISBN- 978-92-4-012340-3 PB - World Health Organization CTI - WHO Guidelines Approved by the Guidelines Review Committee DP - 2026 BTI - WHO guideline on the integrated management of obesity in children AB - This WHO guideline provides adoptable and adaptable, practice- and science-informed global clinical and public health recommendations on the integrated management of obesity in children aged 29 days to under 10 years, using a primary health care approach. Its aim is to support Member States and their partners in improving health, functioning and reducing obesity-associated disability through integrated, people-centred care that considers the diverse needs of children and their families. The guideline presents evidence-informed recommendations on dietary interventions, physical activity, sedentary behaviour and sleep, behaviour changing interventions, digital health interventions, pharmacotherapy, bariatric surgery and weight-management devices, and multimodal interventions. Developed through the WHO guideline process, the recommendations are informed by systematic evidence reviews together with considerations of benefits and harms, equity, feasibility, acceptability, costs, and the values and preferences of children and their caregivers. The guideline is intended for policy-makers, programme managers, health workers and others involved in planning and delivering obesity care for children. CI - (c) World Health Organization 2026. LA - eng PT - Practice Guideline PT - Review PT - Book PL - Geneva EDAT- 2026/01/01 00:00 CRDT- 2026/01/01 00:00 AID - NBK625429 [bookaccession] PMID- 41477274 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260101 LR - 20260103 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 13 DP - 2025 TI - Feasibility and age-related trends of a home-based online exercise program in adolescents with idiopathic scoliosis. PG - 1695963 LID - 10.3389/fped.2025.1695963 [doi] LID - 1695963 AB - BACKGROUND: Idiopathic scoliosis (IS) is a three-dimensional spinal deformity that often progresses during adolescence. While bracing and exercise therapies are standard conservative treatments, limited research has examined the feasibility of fully online, home-based combined exercise programs and the clinical trends observed during participation -especially in adolescents undergoing brace treatment. This single-arm prospective cohort study (without a control group) aimed to evaluate the feasibility of a six-month, fully online, home-based Schroth-Pilates program combined with brace treatment in adolescents with IS, and to observe potential age-related trends in clinical measures and adherence. METHODS: A single-center prospective cohort design was used involving 114 adolescents with IS (Cobb angle 10 degrees -45 degrees ) receiving standard brace treatment. Participants engaged in supervised online Schroth-Pilates sessions three times per week for six months. Primary measures included Cobb angle and ATR, recorded at baseline and post-program. Feasibility was assessed via program completion and adherence rates. Mixed-design ANOVAs were used to explore trends over time and between age groups (10-13 vs. 14-17 years). RESULTS: The overall program completion rate was 97.4%, with no significant adherence differences between age groups. Significant improvements were observed in Cobb angle [F(1,112) = 16.42, p < .001, eta (2) = .255] and ATR [F(1,112) = 11.87, p = .001, eta (2) = .198], both exceeding the minimum clinically important difference for adolescents with IS. Higher adherence was positively correlated with greater reductions in Cobb angle and ATR, suggesting that consistent participation enhanced treatment outcomes. Younger participants demonstrated greater mean improvements, possibly reflecting higher flexibility and growth potential. CONCLUSION: A fully online, home-based Schroth-Pilates program is feasible and clinically effective for adolescents with IS, achieving high adherence and meaningful improvements in spinal curvature and trunk rotation-particularly among younger participants. These results support the clinical viability of virtual scoliosis rehabilitation and highlight the need for future controlled and longitudinal studies to confirm long-term outcomes. CI - (c) 2025 Wang and Su. FAU - Wang, Jing AU - Wang J AD - School of Sports Science and Engineering, East China University of Science and Technology, Shanghai, China. FAU - Su, Youcun AU - Su Y AD - College of Physical Education and Health, East China Normal University, Shanghai, China. LA - eng PT - Journal Article DEP - 20251216 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC12748210 OTO - NOTNLM OT - Pilates OT - Schroth OT - adolescents OT - idiopathic scoliosis OT - online rehabilitation COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2026/01/01 07:37 MHDA- 2026/01/01 07:38 PMCR- 2025/12/16 CRDT- 2026/01/01 04:48 PHST- 2025/09/03 00:00 [received] PHST- 2025/11/03 00:00 [revised] PHST- 2025/11/26 00:00 [accepted] PHST- 2026/01/01 07:38 [medline] PHST- 2026/01/01 07:37 [pubmed] PHST- 2026/01/01 04:48 [entrez] PHST- 2025/12/16 00:00 [pmc-release] AID - 10.3389/fped.2025.1695963 [doi] PST - epublish SO - Front Pediatr. 2025 Dec 16;13:1695963. doi: 10.3389/fped.2025.1695963. eCollection 2025. PMID- 41476221 OWN - NLM STAT- MEDLINE DCOM- 20260203 LR - 20260205 IS - 1749-799X (Electronic) IS - 1749-799X (Linking) VI - 21 IP - 1 DP - 2025 Dec 31 TI - Cross-cultural adaptation and validation of the simplified Chinese version of the functional assessment scale for acute hamstring injuries (FASH) questionnaire. PG - 71 LID - 10.1186/s13018-025-06578-2 [doi] LID - 71 AB - BACKGROUND: The Functional Assessment Scale for Acute Hamstring Injuries (FASH) Questionnaire is a tool to assess the severity of symptoms and their impact on function and sports ability in patients with acute hamstring injuries. The study was to cross-culturally adapt and psychometrically validate a Simplified Chinese version of the FASH (SC-FASH). METHODS: Cross-cultural adaptation was performed in accordance with the internationally recognised guidelines of the American Academy of Orthopaedic Surgeons Outcome Committee. The FASH is a 10-item questionnaire. The sample size should be 5 to 10 times the total number of items on the scale. 150 participants with acute hamstring injuries were included in this study. Cronbach's alpha and the intra-class correlation coefficient (ICC) were used to assess reliability, and correlations between the SC-FASH and the Exercise-Induced Leg Pain Questionnaire (EILP), the Visual Analogue Scale (VAS) and the Short Form (36) Health Survey (SF-36) were used to assess construct validity. RESULTS: Between February and May 2025, 150 literate native Chinese speakers with hamstring injuries were recruited for a study. All the 10 items had an answer rate of 100%. The FASH was successfully adapted and translated into Simplified Chinese. Each item was appropriately correlated with the total items. Good reliabilities were observed in SC-FASH, evidenced by Cronbach's alpha of 0.88, an ICC 0.97 (95% CI, 0.96-0.98). The elimination of any one item did not result in a Cronbach's alpha < 0.80. Standard Error of the Mean (SEM) was 4.41. Good correlations were observed with EILP (0.68, p < 0.01), VAS (-0.62, p < 0.01), and physical function of SF-36 (0.62, p < 0.01). Moderate correlations were observed with role physical (0.46, p < 0.01), bodily pain (0.50, p < 0.01), and general health (0.44, p < 0.01). Fair to poor correlations were observed with vitality, social function, role emotional, and mental health domains of SF-36. CONCLUSION: SC-FASH is recommended to evaluate the severity of hamstring muscle injuries and their impact on physical function and sports ability in Mainland China due to its good reliability, and validity. CI - (c) 2025. The Author(s). FAU - Wu, Yu-Jie AU - Wu YJ AD - Department of Nursing, The Third People's Hospital of Datong, Shanxi, China. FAU - Liu, Ning AU - Liu N AD - Department of Orthopedics, The 960th Hospital of Joint Logistics Support Force, Jinan, Shandong, China. FAU - Zheng, Qiang AU - Zheng Q AD - Department of Emergency Surgery and Orthopaedic Surgery, Qilu Hospital of Shandong University, Jinan, 250012, Shandong, China. FAU - Liu, Kan AU - Liu K AD - Department of Orthopedics, Beijing University of Chinese Medicine Third Affiliated Hospital, Beijing, 100029, People's Republic of China. atmlkmd@126.com. FAU - Zhang, Qing-Meng AU - Zhang QM AD - Department of Orthopaedics, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, People's Republic of China. zhangqingmeng@email.sdu.edu.cn. FAU - Cao, Shi-Qi AU - Cao SQ AD - Orthopaedics of TCM Senior Department, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, 100048, People's Republic of China. sq_cao@126.com. LA - eng GR - ZR2022QH233/Natural Science Foundation of Shandong Province/ PT - Journal Article PT - Validation Study DEP - 20251231 PL - England TA - J Orthop Surg Res JT - Journal of orthopaedic surgery and research JID - 101265112 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - *Hamstring Muscles/injuries MH - *Cross-Cultural Comparison MH - China MH - Young Adult MH - Middle Aged MH - Psychometrics/methods MH - Adolescent MH - *Athletic Injuries/diagnosis PMC - PMC12866478 OTO - NOTNLM OT - Chinese OT - Hamstring Injuries OT - Psychometrics OT - Questionnaire COIS- Declarations. Ethics approval: All procedures performed in this study involving human participants were approved by the medical ethics committee of authors' hospital (S2025-012-04), which followed the ethical standards of the institutional and national research committee and the 1964 Helsinki Declaration and its later amendments (World Medical Association Declaration of Helsinki Ethical Principles for Medical Research Involving Human Participants). Informed consent was obtained from all individual participants included in the study. Consent for publication: Not applicable. Conflict of interest: The authors declare no competing interests. Competing interests: Each author certifies that he or she has no commercial associations (e.g. consultancies, stock ownership, equity interest, patent/licensing arrangements) that might pose a conflict of interest in connection with the submitted article. EDAT- 2026/01/01 00:35 MHDA- 2026/02/03 07:41 PMCR- 2025/12/31 CRDT- 2025/12/31 23:24 PHST- 2025/08/29 00:00 [received] PHST- 2025/11/28 00:00 [accepted] PHST- 2026/02/03 07:41 [medline] PHST- 2026/01/01 00:35 [pubmed] PHST- 2025/12/31 23:24 [entrez] PHST- 2025/12/31 00:00 [pmc-release] AID - 10.1186/s13018-025-06578-2 [pii] AID - 6578 [pii] AID - 10.1186/s13018-025-06578-2 [doi] PST - epublish SO - J Orthop Surg Res. 2025 Dec 31;21(1):71. doi: 10.1186/s13018-025-06578-2. PMID- 41475316 OWN - NLM STAT- MEDLINE DCOM- 20260111 LR - 20260111 IS - 1873-3379 (Electronic) IS - 0891-4222 (Linking) VI - 168 DP - 2026 Jan TI - Unlocking exercise compliance in children with ADHD: A comprehensive analysis of influencing factors. PG - 105202 LID - S0891-4222(25)00286-0 [pii] LID - 10.1016/j.ridd.2025.105202 [doi] AB - BACKGROUND: Despite documented benefits of exercise for children with attention deficit hyperactivity disorder (ADHD), poor adherence to exercise programs limits therapeutic effectiveness. While existing research focuses on symptom outcomes, the behavioral processes and contextual factors influencing sustained exercise participation remain underexplored. AIMS: This study systematically explored facilitators and barriers to exercise compliance-operationally defined as the degree to which a child's actual exercise behavior (frequency, intensity, duration) aligns with prescribed recommendations-in children with ADHD from parental perspectives, using the Capability-Opportunity-Motivation-Behavior (COM-B) model. METHODS AND PROCEDURES: A qualitative descriptive study was conducted with 16 parents (13 mothers, 3 fathers; child age range: 6-12 years) of children diagnosed with ADHD, purposively sampled from a home-based exercise intervention program at a tertiary hospital in China (June-September 2024). Sampling considered child characteristics (age, ADHD subtype) and family socioeconomic status to ensure diverse perspectives. Semi-structured interviews (20-40 min) explored parents' experiences with their children's exercise participation. Data were analyzed using directed content analysis, whereby transcripts were systematically coded line-by-line within the COM-B framework while remaining open to inductive subtheme emergence. Data saturation was achieved at 16 interviews. OUTCOMES AND RESULTS: Analysis identified 12 distinct subthemes across three COM-B domains. Capability barriers included motor skill deficits, attention difficulties, emotional dysregulation, and limited self-management, collectively undermining children's confidence and willingness to exercise. Opportunity factors functioned bidirectionally: parental knowledge, companionship, peer support, and facility accessibility enhanced adherence; financial constraints, lack of parental time, and excessive academic workload-particularly salient in China's high-pressure educational context-significantly impeded participation. Motivation evolved dynamically, with external rewards initially driving engagement but intrinsic interest and perceived symptom improvement sustaining long-term adherence. CONCLUSIONS AND IMPLICATIONS: This study provides the first theoretically grounded, qualitative examination of exercise adherence processes (rather than solely outcomes) in pediatric ADHD. Findings reveal culture-specific barriers and the dynamic interplay among capability, opportunity, and motivation. Clinicians should conduct individualized capability assessments before prescribing exercise and tailor programs to children's motor abilities. Educators can adjust homework loads and integrate movement breaks. Parents should prioritize exercise companionship and employ structured reinforcement. These exploratory findings from a single-center Chinese sample require validation in diverse populations. CI - Copyright (c) 2026 Elsevier Ltd. All rights reserved. FAU - Zhang, Pei AU - Zhang P AD - Department of Nursing, Harbin Medical University, Daqing Campus, Daqing, Heilongjiang 163319, China. Electronic address: zjs17864180613@163.com. FAU - Zhao, Gang AU - Zhao G AD - Department of Traditional Chinese Medicine, Shenzhen Children's Hospital, Shenzhen, Guangdong, 518026, China. Electronic address: zgang230@126.com. FAU - Li, Junru AU - Li J AD - Department of Nursing, Harbin Medical University, Daqing Campus, Daqing, Heilongjiang 163319, China. Electronic address: 919874577@qq.com. FAU - Tian, Xian AU - Tian X AD - Department of Nursing, Harbin Medical University, Daqing Campus, Daqing, Heilongjiang 163319, China. Electronic address: tianxian20230828@163.com. FAU - Xiao, Lingrong AU - Xiao L AD - Department of Nursing, Harbin Medical University, Daqing Campus, Daqing, Heilongjiang 163319, China. Electronic address: 1670705466@qq.com. FAU - Diao, Hongzhu AU - Diao H AD - Department of Nursing, Harbin Medical University, Daqing Campus, Daqing, Heilongjiang 163319, China. Electronic address: 3294457379@qq.com. FAU - Xu, Xiaoqing AU - Xu X AD - Department of Nursing, Harbin Medical University, Daqing Campus, Daqing, Heilongjiang 163319, China. Electronic address: 3136866838@qq.com. FAU - Jin, Yisi AU - Jin Y AD - Daqing People's Hospital, Daqing, Heilongjiang 163311, China. Electronic address: jjs2468@sina.com. FAU - Wu, Hongmei AU - Wu H AD - Department of Nursing, Harbin Medical University, Daqing Campus, Daqing, Heilongjiang 163319, China; Key Laboratory of Basic Research and Health Management on Chronic Diseases in Heilongjiang Province, Daqing, Heilongjiang,163319, China. Electronic address: woom@163.com. LA - eng PT - Journal Article DEP - 20251230 PL - United States TA - Res Dev Disabil JT - Research in developmental disabilities JID - 8709782 SB - IM MH - Humans MH - *Attention Deficit Disorder with Hyperactivity/psychology/therapy/rehabilitation MH - Child MH - Female MH - Male MH - Motivation MH - *Patient Compliance/psychology MH - *Parents/psychology MH - Qualitative Research MH - *Exercise Therapy/psychology/methods MH - *Exercise/psychology MH - China MH - Adult OTO - NOTNLM OT - ADHD OT - COM-B model OT - Children OT - Exercise adherence OT - Parental perspectives OT - Qualitative research COIS- Declaration of Competing Interest The authors declare that there is no conflict of interest. EDAT- 2026/01/01 00:35 MHDA- 2026/01/12 00:37 CRDT- 2025/12/31 18:13 PHST- 2025/08/15 00:00 [received] PHST- 2025/12/26 00:00 [revised] PHST- 2025/12/26 00:00 [accepted] PHST- 2026/01/12 00:37 [medline] PHST- 2026/01/01 00:35 [pubmed] PHST- 2025/12/31 18:13 [entrez] AID - S0891-4222(25)00286-0 [pii] AID - 10.1016/j.ridd.2025.105202 [doi] PST - ppublish SO - Res Dev Disabil. 2026 Jan;168:105202. doi: 10.1016/j.ridd.2025.105202. Epub 2025 Dec 30. PMID- 41474788 OWN - NLM STAT- MEDLINE DCOM- 20251231 LR - 20260513 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 12 DP - 2025 TI - Exploring gut microbiome and nutritional status among children with Autism Spectrum Disorder (MY-ASD Microbiome): A study protocol. PG - e0338801 LID - 10.1371/journal.pone.0338801 [doi] LID - e0338801 AB - BACKGROUND: Autism Spectrum Disorder (ASD) is a neurodevelopmental disorder characterised by persistent deficits in social communication and the presence of restricted, repetitive behaviours or interests. Previous literature has identified a link between the gut and ASD; however, the underlying mechanisms remain unclear. Gut microbiota dysbiosis has been extensively reported in cohort studies of ASD, and specific microbial metabolites or by-products may serve as potential biomarkers for ASD. Additionally, children with ASD often exhibit food refusal, have a limited food repertoire and display a tendency to consume the same foods frequently; thus, these behaviours increase their risk of malnutrition (over-nutrition or under-nutrition) compared to typically developing (TD) healthy children. This study primarily aims to identify oral and gut microbiota among children with ASD and TD healthy children. The secondary aim is to determine the associations between oral and gut microbiota with nutritional status among children with ASD. The findings will enhance understanding of the aetiology of ASD and inform early intervention strategies to mitigate disease severity and early identification of malnutrition in genetically at-risk children. METHODS AND ANALYSIS: This observational, age-matched, case-control study is conducted in Malaysia among 40 male children with ASD and age-matched with 40 TD healthy controls aged 4-10 years. The dependent variables include the microbiota profile, identified through metagenomic sequencing analysis of saliva and faecal samples, and autism severity, assessed through validated questionnaires. Independent variables include nutritional status, determined through Subjective Global Nutrition Assessment (SGNA), anthropometry and dietary measurements, gastrointestinal symptoms, eating behaviour, behavioural profile, and sleep quality. Data collection is expected to be completed by June 2026. The study nature may limit causality establishment. Analyses will use chi-square/ANOVA for group comparisons, SparCC for microbiota correlations, and mixed-effects logistic regression to model associations. CONCLUSION: This study advances understanding of ASD-related microbiota, guiding personalised nutrition and precision healthcare in Malaysia. CI - Copyright: (c) 2025 Wong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Wong, Kai Xuan AU - Wong KX AUID- ORCID: 0009-0004-5349-9180 AD - Centre of Postgraduate Studies by Research, IMU University, Kuala Lumpur, Malaysia. AD - Institute for Research, Development and Innovation (IRDI), IMU University, Kuala Lumpur, Malaysia. FAU - Chen, Seong Ting AU - Chen ST AD - Division of Nutrition and Dietetics, IMU University, Kuala Lumpur, Malaysia. FAU - Ong, Jun Jean AU - Ong JJ AD - Paediatric Department, School of Medicine, IMU Clinical Campus Seremban, Negeri Sembilan, Malaysia. FAU - Gan, Wan Ying AU - Gan WY AUID- ORCID: 0000-0002-9016-3414 AD - Department of Nutrition, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Selangor, Malaysia. FAU - Abdul Murad, Nor Azian AU - Abdul Murad NA AD - UKM Medical Molecular Biology Institute (UMBI), Universiti Kebangsaan Malaysia (UKM), Cheras, Kuala Lumpur, Malaysia. FAU - Chong, Chun Wie AU - Chong CW AD - (FUTURE) Monash Microbiome Research Centre, Monash University Malaysia, Bandar Sunway, Selangor, Malaysia. FAU - Ramzi, Nurul Hanis AU - Ramzi NH AUID- ORCID: 0000-0002-7622-7581 AD - Institute for Research, Development and Innovation (IRDI), IMU University, Kuala Lumpur, Malaysia. AD - Centre for Cancer and Stem Cell Research, Institute for Research, Development and Innovation, IMU University, Kuala Lumpur, Malaysia. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20251231 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Child MH - Child, Preschool MH - Female MH - Humans MH - Male MH - *Autism Spectrum Disorder/microbiology MH - Case-Control Studies MH - Feces/microbiology MH - *Gastrointestinal Microbiome MH - Malaysia MH - *Nutritional Status MH - Saliva/microbiology MH - Observational Studies as Topic PMC - PMC12755732 COIS- The authors have declared that no competing interests exist. EDAT- 2025/12/31 19:16 MHDA- 2025/12/31 19:17 PMCR- 2025/12/31 CRDT- 2025/12/31 13:53 PHST- 2025/02/24 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2025/12/31 19:17 [medline] PHST- 2025/12/31 19:16 [pubmed] PHST- 2025/12/31 13:53 [entrez] PHST- 2025/12/31 00:00 [pmc-release] AID - PONE-D-25-08831 [pii] AID - 10.1371/journal.pone.0338801 [doi] PST - epublish SO - PLoS One. 2025 Dec 31;20(12):e0338801. doi: 10.1371/journal.pone.0338801. eCollection 2025. PMID- 41474767 OWN - NLM STAT- MEDLINE DCOM- 20260202 LR - 20260202 IS - 1536-0911 (Electronic) IS - 1536-0903 (Linking) VI - 26 IP - 1 DP - 2026 Feb 1 TI - Early Kangaroo Mother Care in Preterm Infants, Implications, Timing, and Feasibility: A Systematic Review. PG - 73-81 LID - 10.1097/ANC.0000000000001335 [doi] AB - BACKGROUND: Kangaroo mother care (KMC) is an effective care practice for preterm infants, based on early and continuous skin-to-skin contact between mother and newborn, with benefits on physiological stability, reduction of mortality, and promotion of lactation. However, the optimal timing for early initiation of KMC is still under investigation. PURPOSE: To explore the clinical and organizational implications of early initiation of KMC in preterm infants, with particular attention to the timing of initiation. DATA SOURCES: Systematic review conducted in April 2025 on Medline (PubMed) and Cochrane Library. STUDY SELECTION: Studies published since 2016 in Italian or English were included. Articles prior to 2016, reviews and irrelevant studies were excluded. Four studies were selected for the final analysis. DATA EXTRACTION: Two independent reviewers selected and analyzed the studies, extracting data on clinical context, timing of initiation, and main outcomes. RESULTS: Early KMC, started within 24 hours of birth in preterm or low birth-weight infants, promotes greater physiological stability; reduces mortality by up to 25%; and improves breastfeeding, growth, and neurodevelopment. Ultra-early initiation (within 1.3 hours) is effective even in newborns with moderate clinical instability. The nurse plays a central role in the promotion and management of early KMC. IMPLICATIONS FOR PRACTICE AND RESEARCH: The integration of early KMC into routine care requires specific training, organizational support, and active involvement of families. Further studies are needed to consolidate the evidence and define universal protocols. CI - Copyright (c) 2025 by The National Association of Neonatal Nurses. FAU - Laus, Gennaro AU - Laus G AUID- ORCID: 0009-0000-0299-6145 AD - Author Affiliations: Department of Services, IRCCS CROB: Istituto di Ricovero e Cura a Carattere Scientifico Centro di Riferimento Oncologico della Basilicata, Rionero in Vulture, Potenza, Italy (Dr Laus); Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy (Prof Cassano); and Emergency Department, United Polyclinic of Foggia and University of Foggia, Foggia, Italy (Dr Zerulo). FAU - Cassano, Tommaso AU - Cassano T FAU - Zerulo, Sipontina Rita AU - Zerulo SR LA - eng PT - Journal Article PT - Systematic Review DEP - 20251230 PL - United States TA - Adv Neonatal Care JT - Advances in neonatal care : official journal of the National Association of Neonatal Nurses JID - 101125644 SB - IM MH - Humans MH - *Kangaroo-Mother Care Method/methods MH - Infant, Newborn MH - *Infant, Premature MH - Time Factors MH - Breast Feeding MH - Infant, Low Birth Weight MH - Female OTO - NOTNLM OT - Kangaroo mother care method OT - neonatal intensive care OT - nursing care OT - premature infant OT - time factors EDAT- 2025/12/31 19:16 MHDA- 2026/02/02 19:41 CRDT- 2025/12/31 13:44 PHST- 2026/02/02 19:41 [medline] PHST- 2025/12/31 19:16 [pubmed] PHST- 2025/12/31 13:44 [entrez] AID - 00149525-990000000-00240 [pii] AID - 10.1097/ANC.0000000000001335 [doi] PST - ppublish SO - Adv Neonatal Care. 2026 Feb 1;26(1):73-81. doi: 10.1097/ANC.0000000000001335. Epub 2025 Dec 30. PMID- 41474687 OWN - NLM STAT- MEDLINE DCOM- 20260413 LR - 20260920 IS - 1421-9697 (Electronic) IS - 0250-6807 (Print) IS - 0250-6807 (Linking) VI - 82 IP - 2 DP - 2026 TI - Advancement on the Association between Gut Microbiota and Autism Spectrum Disorder in Children. PG - 115-129 LID - 10.1159/000549716 [doi] AB -

Background: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by deficits in social interaction, communication, and the presence of restricted, repetitive behaviors. The rising global prevalence of ASD suggests a multifactorial etiology involving genetic, environmental, and neurodevelopmental factors. This review explores the establishment of the early life microbiome, highlighting rapid microbial colonization from maternal and environmental sources. Emerging evidence indicates that delivery mode and infant feeding practices may influence ASD susceptibility. Although the concept of a sterile intrauterine environment remains debated, its investigation is valuable. Summary: This review provides a comprehensive analysis of the interplay between diet, gastrointestinal symptoms, and ASD, evaluates the gut-brain axis as a mechanistic framework, and assesses the therapeutic potential of microbial interventions. The bidirectional "microbiota-gut-brain axis" has emerged as a critical pathway linking gut microbiota and brain function, offering potential therapeutic targets for ASD. Dietary patterns in children with ASD are often characterized by selectivity and restriction, which may disrupt gut microbiota composition and exacerbate gastrointestinal symptoms, thereby increasing ASD risk. Nutritional interventions and early behavioral therapies are thus essential. Key Messages: The gluten-free, casein-free diet remains controversial, with inconsistent evidence regarding its efficacy. Probiotic supplementation shows strain-specific effects, necessitating rigorous evaluation before clinical application. Given the heterogeneity of ASD, pharmacological treatments have shown limited universal efficacy. While promising findings have emerged from research on probiotics, prebiotics, and fecal microbiota transplantation, further well-designed clinical studies are needed to elucidate the complex etiology of ASD and validate therapeutic strategies.

. CI - (c) 2025 The Author(s). Published by S. Karger AG, Basel. FAU - Abulaiti, Adila AU - Abulaiti A AD - Kashi University School of Medicine, Institute of etiology and prevention of metabolic diseases in Pamir Plateau Area, Xinjiang, China. FAU - Yu, Huanhuan AU - Yu H AD - Kashi University School of Medicine, Institute of etiology and prevention of metabolic diseases in Pamir Plateau Area, Xinjiang, China. FAU - Ma, Junmei AU - Ma J AD - Kashi University School of Medicine, Institute of etiology and prevention of metabolic diseases in Pamir Plateau Area, Xinjiang, China. FAU - Wuji, Anikezi AU - Wuji A AD - Kashi University School of Medicine, Institute of etiology and prevention of metabolic diseases in Pamir Plateau Area, Xinjiang, China. FAU - Chi, Honggang AU - Chi H AD - Kashi University School of Medicine, Institute of etiology and prevention of metabolic diseases in Pamir Plateau Area, Xinjiang, China, chg@gdmu.edu.cn. AD - The First Dongguan Affiliated Hospital, Guangdong Medical University, Guangdong, China, chg@gdmu.edu.cn. LA - eng PT - Journal Article PT - Review DEP - 20251231 PL - Switzerland TA - Ann Nutr Metab JT - Annals of nutrition & metabolism JID - 8105511 SB - IM MH - Humans MH - *Autism Spectrum Disorder/microbiology/etiology MH - *Gastrointestinal Microbiome/physiology MH - Child MH - Probiotics/therapeutic use MH - Diet MH - Diet, Gluten-Free MH - Female PMC - PMC12872196 OTO - NOTNLM OT - Autism spectrum disorder OT - Gut microbiota OT - Microbial therapy OT - Microbiota-gut-brain axis OT - Probiotics COIS- The authors declare no conflicts of interest. EDAT- 2025/12/31 19:16 MHDA- 2026/04/13 18:31 PMCR- 2025/12/31 CRDT- 2025/12/31 13:26 PHST- 2025/02/02 00:00 [received] PHST- 2025/11/02 00:00 [accepted] PHST- 2026/04/13 18:31 [medline] PHST- 2025/12/31 19:16 [pubmed] PHST- 2025/12/31 13:26 [entrez] PHST- 2025/12/31 00:00 [pmc-release] AID - 000549716 [pii] AID - 549716 [pii] AID - 10.1159/000549716 [doi] PST - ppublish SO - Ann Nutr Metab. 2026;82(2):115-129. doi: 10.1159/000549716. Epub 2025 Dec 31. PMID- 41474645 OWN - NLM STAT- MEDLINE DCOM- 20251231 LR - 20260103 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 27 DP - 2025 Dec 31 TI - Effectiveness of Digital Interventions for Low-Income, Food-Insecure Populations: Natural Language Processing Study of WIC Smartphone App User Reviews, 2013-2024. PG - e78984 LID - 10.2196/78984 [doi] LID - e78984 AB - BACKGROUND: The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) is a federal nutrition assistance program for low-income, food-insecure mothers and young children in the United States. Despite its intended goals, many eligible individuals forgo WIC benefits, in part due to administrative burden-defined as the complex, often frustrating processes encountered when navigating public benefit programs. In response, a range of digital interventions and policy waivers were introduced during the COVID-19 pandemic, but their effectiveness in reducing barriers remains unclear. OBJECTIVE: Drawing from administrative burden theory and human-computer interaction research, this study examined user reviews of WIC smartphone apps (WIC Apps) used by local agencies. Specifically, it investigated (1) how obstacles to WIC access manifested in daily app use, (2) how user experiences shifted after the onset of the COVID-19 pandemic, and (3) how these changes were associated with app ratings. METHODS: An original dataset of user reviews (Nreview=28,212) was compiled for 26 WIC Apps between 2013 and 2024. Structural topic modeling identified 8 key themes, and sentiment was examined with Robustly Optimized Bidirectional Encoder Representations From Transformers Pretraining Approach. Analyses compared topic prevalence and sentiment distributions before and after COVID-19. Mixed-effects models examined the relationship between topics, sentiment, and app ratings. RESULTS: Technical concerns related to account authentication and login, document upload, and app updates were among the most prevalent themes. These issues were typically expressed with negative sentiment and appeared more frequently in pre-COVID-19 reviews than in post-COVID-19 reviews. Although reliability problems (eg, outages and maintenance) persisted, post-COVID-19 reviews increasingly emphasized features that facilitated program tracking, shopping and benefit redemption, and general ease of use, which were generally described with positive sentiment. Mixed-effects analyses indicated that these post-COVID-19 topics were significantly associated with higher app ratings (program tracking: B=0.21, SE=0.06; P=.001; shopping and redemption: B=0.18, SE=0.07; P=.01; and ease of use: B=0.10, SE=0.05; P=.04), whereas pre-COVID-19 concerns were not associated with ratings (Ps>.05). When sentiment was added to the mixed-effect model, it became the dominant factor: negative sentiment was associated with lower ratings (B=-1.71, SE=0.03; P<.001), and positive sentiment was associated with higher ratings (B=1.78, SE=0.03; P<.001). After accounting for sentiment, no individual topic was significantly associated with ratings (Ps>.05), suggesting that sentiment contributed to much of the variance previously linked to topics. CONCLUSIONS: User-centered digital interventions, such as WIC Apps, have the potential to support WIC access and participation. CI - (c) Jihye Lee. Originally published in the Journal of Medical Internet Research (https://www.jmir.org). FAU - Lee, Jihye AU - Lee J AUID- ORCID: 0000-0003-0245-7250 AD - Stan Richards School of Advertising and Public Relations, Moody College of Communication, The University of Texas at Austin, 300 W Dean Keeton DMC 4.314 (A1200), Austin, TX, 78712, United States, 1 512 471 1101. LA - eng PT - Journal Article DEP - 20251231 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 SB - IM MH - Humans MH - *Mobile Applications MH - COVID-19/epidemiology MH - *Poverty MH - *Food Assistance MH - *Natural Language Processing MH - *Smartphone MH - United States MH - *Food Insecurity MH - Female MH - SARS-CoV-2 PMC - PMC12755294 OTO - NOTNLM OT - COVID-19 OT - Special Supplemental Nutrition Program for Women, Infants, and Children OT - WIC OT - administrative burden OT - digital interventions OT - natural language processing OT - smartphone apps COIS- Conflicts of Interest: None declared. EDAT- 2025/12/31 19:16 MHDA- 2025/12/31 19:17 PMCR- 2025/12/31 CRDT- 2025/12/31 13:12 PHST- 2025/06/13 00:00 [received] PHST- 2025/10/05 00:00 [revised] PHST- 2025/10/07 00:00 [accepted] PHST- 2025/12/31 19:17 [medline] PHST- 2025/12/31 19:16 [pubmed] PHST- 2025/12/31 13:12 [entrez] PHST- 2025/12/31 00:00 [pmc-release] AID - v27i1e78984 [pii] AID - 78984 [pii] AID - 10.2196/78984 [doi] PST - epublish SO - J Med Internet Res. 2025 Dec 31;27:e78984. doi: 10.2196/78984. PMID- 41474475 OWN - NLM STAT- MEDLINE DCOM- 20251231 LR - 20260926 IS - 1432-0711 (Electronic) IS - 0932-0067 (Print) IS - 0932-0067 (Linking) VI - 313 IP - 1 DP - 2025 Dec 31 TI - Antepartum prediction of shoulder dystocia using machine learning. PG - 3 LID - 10.1007/s00404-025-08271-5 [doi] LID - 3 AB - PURPOSE: Shoulder dystocia (SD) is a serious delivery complication, often occurring without identifiable risk factors. Accurate risk assessment is essential for educated decisions regarding the mode of delivery. This study aimed to develop and validate a machine learning-based model for SD prediction. METHODS: We conducted a retrospective analysis of term singleton vaginal deliveries at a single academic hospital over 10 years. Exclusion criteria included cesarean deliveries and multiple gestations. Maternal and fetal characteristics were compared between SD and non-SD cases. Eleven features were selected for model development. Missing values in normally distributed variables were imputed using mean values. To address class imbalance, repeated random sampling of non-SD cases was performed. Data were split into training and test sets (70:30) and standardized. Multiple machine learning models-including logistic regression, decision tree, random forest, support vector machine, XGBoost, and CatBoost-were evaluated using cross-validation and area under the ROC curve (AUC). RESULTS: Among 51,628 deliveries, 94 (0.18%) involved SD. SD was associated with higher BMI, shorter stature, and increased diabetes rates (all p < 0.05). Mean birthweight was significantly higher in the SD group (3751 g vs 3287 g, p < 0.01). The CatBoost model achieved the highest performance (AUC = 0.83, 95% CI 0.77-0.89). Key predictive features were sonographic estimated fetal weight (EFW, 55.6% of the model's decision-making weight), maternal BMI (20.1%), and clinical EFW (7.9%). CONCLUSION: Our machine learning-based model predicted SD with an AUC of 0.83 and may support clinicians in delivery planning. CI - (c) 2025. The Author(s). FAU - Heresco, Lior AU - Heresco L AD - Department of Obstetrics and Gynecology, Meir Medical Center, affiliated with the Gray Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. lior160@gmail.com. FAU - Levy, Noa AU - Levy N AD - Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel. FAU - Todress, Omer AU - Todress O AD - Department of Biomedical Engineering, Faculty of Engineering, Tel Aviv University, Tel Aviv, Israel. FAU - Gluska, Hadar AU - Gluska H AD - Department of Obstetrics and Gynecology, Meir Medical Center, affiliated with the Gray Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Biron-Shental, Tal AU - Biron-Shental T AD - Department of Obstetrics and Gynecology, Meir Medical Center, affiliated with the Gray Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Weitzner, Omer AU - Weitzner O AD - Department of Obstetrics and Gynecology, Meir Medical Center, affiliated with the Gray Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. LA - eng PT - Journal Article DEP - 20251231 PL - Germany TA - Arch Gynecol Obstet JT - Archives of gynecology and obstetrics JID - 8710213 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Retrospective Studies MH - *Machine Learning MH - *Shoulder Dystocia/diagnosis/epidemiology/etiology MH - Adult MH - Risk Assessment/methods MH - Birth Weight MH - ROC Curve MH - Logistic Models MH - Delivery, Obstetric MH - Risk Factors MH - Body Mass Index MH - Infant, Newborn PMC - PMC12756293 OTO - NOTNLM OT - Machine learning OT - Shoulder dystocia OT - Vaginal delivery COIS- Declarations. Conflict of interest: The authors have no relevant financial or non-financial interests to disclose. EDAT- 2025/12/31 12:54 MHDA- 2025/12/31 12:55 PMCR- 2025/12/31 CRDT- 2025/12/31 11:18 PHST- 2025/10/14 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2025/12/31 12:55 [medline] PHST- 2025/12/31 12:54 [pubmed] PHST- 2025/12/31 11:18 [entrez] PHST- 2025/12/31 00:00 [pmc-release] AID - 10.1007/s00404-025-08271-5 [pii] AID - 8271 [pii] AID - 10.1007/s00404-025-08271-5 [doi] PST - epublish SO - Arch Gynecol Obstet. 2025 Dec 31;313(1):3. doi: 10.1007/s00404-025-08271-5. PMID- 41473018 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251231 LR - 20260102 IS - 2666-6677 (Electronic) IS - 2666-6677 (Linking) VI - 24 DP - 2025 Dec TI - Wearable device-measured physical activity and risk of MAFLD in adolescents. PG - 101345 LID - 10.1016/j.ajpc.2025.101345 [doi] LID - 101345 AB - BACKGROUND: While physical activity is known to affect the risk of MAFLD in adults, evidence in adolescents is limited and often based on self-reported questionnaires. We therefore used wearable device-based measurements to investigate the association between physical activity and MAFLD in adolescents. METHODS: Data were obtained from the National Health and Nutrition Examination Survey (NHANES) database for adolescents aged 12-19 years during the 2003-2006 and 2011-2014 cycle. Physical activity was measured using wearable accelerometers, averaged across all valid wearing days. Weighted multivariate logistic regressions were applied to assess associations between physical activity (overall, daytime, and nighttime) and MAFLD. RESULT: Among 5705 adolescents, higher physical activity levels were strongly associated with lower odds of MAFLD in the 2003-2006 cycle, with a clear dose-response trend across quartiles (P for trend < 0.001). Participants in the highest physical activity (Q4) had 60 % lower odds overall, 58 % lower odds for daytime, and 43 % lower odds for nighttime activity, compared with those with lowest physical activity (Q1). The association between higher physical activity and lower MAFLD risk was generally observed across sex, age, and income subgroups. In contrast, no significant association between physical activity and MAFLD risk was observed in the 2011-2014 cycle. CONCLUSION: Our results suggest that higher levels of physical activity, especially during the daytime, may protect against MAFLD in adolescents. Our findings offer partial evidence for the role of circadian activity patterns in MAFLD risk and underscore the need for future studies to validate these associations. CI - (c) 2025 The Authors. Published by Elsevier B.V. FAU - Wang, Ruli AU - Wang R AD - Department of Paediatrics, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, China. FAU - You, Congwei AU - You C AD - Department of Paediatrics, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China. FAU - Dong, Zijuan AU - Dong Z AD - Department of Paediatrics, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, China. FAU - Zheng, Qingqing AU - Zheng Q AD - Department of Paediatrics, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China. FAU - Zheng, Xiaowei AU - Zheng X AD - Public Health Research Center and Department of Public Health and Preventive Medicine, Wuxi School of Medicine, Jiangnan University, Wuxi, China. FAU - Zhou, Liangbin AU - Zhou L AD - Department of Biomedical Engineering, Faculty of Engineering, The Chinese University of Hong Kong, Hong Kong, China. FAU - Wang, Xiaolei AU - Wang X AD - Department of Paediatrics, Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi, China. FAU - Zhang, Le AU - Zhang L AD - Department of Paediatrics, Affiliated Children's Hospital of Jiangnan University (Wuxi Children's Hospital), Wuxi, China. FAU - Zhang, Haoyang AU - Zhang H AD - Department of Experimental Medical Science, Lund University, Lund, Sweden. LA - eng PT - Journal Article DEP - 20251103 PL - Netherlands TA - Am J Prev Cardiol JT - American journal of preventive cardiology JID - 101769122 PMC - PMC12746288 OTO - NOTNLM OT - Adolescent OT - MAFLD OT - Physical activity OT - Wearable devices COIS- We wish to confirm that there are no known conflicts of interest associated with this publication and there has been no significant financial support for this work that could have influenced its outcome EDAT- 2025/12/31 07:37 MHDA- 2025/12/31 07:38 PMCR- 2025/11/03 CRDT- 2025/12/31 04:48 PHST- 2025/08/19 00:00 [received] PHST- 2025/10/15 00:00 [revised] PHST- 2025/11/02 00:00 [accepted] PHST- 2025/12/31 07:38 [medline] PHST- 2025/12/31 07:37 [pubmed] PHST- 2025/12/31 04:48 [entrez] PHST- 2025/11/03 00:00 [pmc-release] AID - S2666-6677(25)00420-9 [pii] AID - 101345 [pii] AID - 10.1016/j.ajpc.2025.101345 [doi] PST - epublish SO - Am J Prev Cardiol. 2025 Nov 3;24:101345. doi: 10.1016/j.ajpc.2025.101345. eCollection 2025 Dec. PMID- 41470886 OWN - NLM STAT- MEDLINE DCOM- 20251231 LR - 20260103 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 24 DP - 2025 Dec 17 TI - Learning from Peers: A Qualitative Study to Inform the Development of a Community Tailored Peer Support Intervention to Support Healthy Infant Growth. LID - 10.3390/nu17243941 [doi] LID - 3941 AB - BACKGROUND: Obesity is a chronic disease that has negative health consequences for children. Peer support models have been used to manage chronic diseases like diabetes; however, little is known about how a peer support intervention might promote healthy infant growth to prevent pediatric obesity. The aim of this project was to explore parental perspectives on how a peer support intervention might be developed to support healthy infant weight gain and nutrition. METHODS: Data were collected from November 2022 to October 2023 at a single pediatric primary care clinic. Semi-structured interviews explored parents' perspectives of how a peer parent coach could promote healthy infant nutrition and growth. Interviews focused on (1) common infant feeding and nutrition questions, (2) the role and importance of peer support during the newborn period, and (3) strategies for addressing and facilitating connections to food-related resources and addressing food insecurity. RESULTS: A total of 18 interviews were conducted. Average parental age was 32.1 years (range 20-46 years). Thirty-three percent of the participants identified as Black, 28% identified as White, 11% identified as Asian, and the remaining identified as Other or preferred not to report. Half of the sample reported a household income of <$20,000, 67% reported having public insurance, and 11% reported household food insecurity. Themes that emerged included: peer parent coaches can (1) provide emotional support to families with young infants, (2) education focused on infant nutrition, and (3) facilitate connections with nutrition resources. Participants also noted the importance of understanding a family's unique culture when counseling on infant growth and nutrition. CONCLUSIONS: Multiple themes were identified about how a peer support intervention could support healthy infant nutrition and growth. Future work should test the feasibility and acceptability of a peer support intervention to promote healthy infant weight gain. FAU - Orr, Colin J AU - Orr CJ AUID- ORCID: 0000-0002-0729-238X AD - Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA. AD - Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. FAU - Acosta, Alexander AU - Acosta A AD - Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. FAU - Acosta, Luis AU - Acosta L AD - Department of Pediatrics, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. FAU - Palmquist, Aunchalee E L AU - Palmquist AEL AUID- ORCID: 0000-0002-0848-6952 AD - Duke Global Health Institute, Duke University School of Medicine, Durham, NC 27710, USA. FAU - Price, Carrigan AU - Price C AD - Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. FAU - Guterriez-Wu, Jennifer AU - Guterriez-Wu J AD - Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. FAU - Gaona, Adriana R AU - Gaona AR AD - Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. FAU - Fisher, Edwin B AU - Fisher EB AUID- ORCID: 0000-0003-0234-7465 AD - Peers for Progress, Department of Health Behavior, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. LA - eng GR - 1P30DK092926-22/NH/NIH HHS/United States GR - 1K23DK132513-03/NH/NIH HHS/United States GR - N/A/University of North Carolina Research Institute/ PT - Journal Article DEP - 20251217 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - *Peer Group MH - Female MH - Adult MH - Infant MH - Male MH - Qualitative Research MH - Middle Aged MH - *Social Support MH - Parents/psychology MH - Young Adult MH - *Infant Nutritional Physiological Phenomena MH - Infant, Newborn MH - *Pediatric Obesity/prevention & control MH - Food Insecurity MH - *Child Development PMC - PMC12735634 OTO - NOTNLM OT - food insecurity OT - infant food insecurity OT - infant growth OT - pediatric obesity OT - peer parent coach COIS- The authors declare no conflict of interest. EDAT- 2025/12/31 07:37 MHDA- 2025/12/31 07:38 PMCR- 2025/12/17 CRDT- 2025/12/31 01:05 PHST- 2025/11/05 00:00 [received] PHST- 2025/12/08 00:00 [revised] PHST- 2025/12/11 00:00 [accepted] PHST- 2025/12/31 07:38 [medline] PHST- 2025/12/31 07:37 [pubmed] PHST- 2025/12/31 01:05 [entrez] PHST- 2025/12/17 00:00 [pmc-release] AID - nu17243941 [pii] AID - nutrients-17-03941 [pii] AID - 10.3390/nu17243941 [doi] PST - epublish SO - Nutrients. 2025 Dec 17;17(24):3941. doi: 10.3390/nu17243941. PMID- 41470869 OWN - NLM STAT- MEDLINE DCOM- 20251231 LR - 20260103 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 24 DP - 2025 Dec 15 TI - Virtual Reality Trier Social Stress and Virtual Supermarket Exposure: Electrocardiogram Correlates of Food Craving and Eating Traits in Adolescents. LID - 10.3390/nu17243924 [doi] LID - 3924 AB - BACKGROUND/OBJECTIVES: Acute stress is known to influence food-related motivation and decision-making, often promoting a preference for energy-dense, palatable foods. However, traditional laboratory paradigms have limited ecological validity. This study examined the relationship between stress-induced physiological changes, eating behavior traits, and food cravings using a virtual reality (VR) adaptation of the Trier Social Stress Test (VR-TSST) followed by a VR supermarket task in adolescents. METHODS: Thirty-eight adolescents (mean age 15.8 +/- 0.6 years) participated in the study. Physiological parameters (HR, QT, PQ intervals) were recorded pre- and post-stress using a portable ECG device (WIWE). Perceived stress and eating behavior traits were evaluated with the Perceived Stress Scale (PSS) and the Three-Factor Eating Questionnaire (TFEQ-R21C), respectively. Immediately after the VR-TSST, participants performed a VR supermarket task in which they rated cravings for sweet, fatty, and healthy foods using visual analog scales (VAS). Paired-samples t-tests examined pre-post changes in physiological parameters, partial correlations explored associations between ECG responses and eating traits, and a 2 x 3 mixed-model Repeated Measures ANOVA assessed the effects of food type (sweet, fatty, healthy) and uncontrolled eating (UE) group (low vs. high) on post-stress cravings. RESULTS: Acute stress induced significant increases in HR and QTc intervals (p < 0.01), confirming a robust physiological stress response. The ANOVA revealed a strong main effect of food type (F(1.93, 435.41) = 168.98, p < 0.001, eta(2)p = 0.43), indicating that stress-induced cravings differed across food categories, with sweet foods rated highest. A significant food type x UE group interaction (F(1.93, 435.41) = 16.49, p < 0.001, eta(2)p = 0.07) showed that adolescents with high UE exhibited greater cravings for sweet and fatty foods than those with low UE. Overall, craving levels did not differ significantly between groups. CONCLUSIONS: The findings demonstrate that acute stress selectively enhances cravings for high-reward foods, and that this effect is modulated by baseline uncontrolled eating tendencies. The combined use of VR-based stress induction and VR supermarket simulation offers an innovative, ecologically valid framework for studying stress-related eating behavior in adolescents, with potential implications for personalized nutrition and the prevention of stress-induced overeating. FAU - Onita, Cristiana Amalia AU - Onita CA AUID- ORCID: 0009-0006-7088-3971 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700588 Iasi, Romania. FAU - Matei, Daniela-Viorelia AU - Matei DV AUID- ORCID: 0000-0002-4609-7288 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700588 Iasi, Romania. FAU - Chelarasu, Elena AU - Chelarasu E AD - Computer Science Department, Faculty of Automatic Control and Computer Science, Gheorghe Asachi Technical University of Iasi, 700050 Iasi, Romania. FAU - Lupu, Robert Gabriel AU - Lupu RG AUID- ORCID: 0000-0002-2494-1070 AD - Computer Science Department, Faculty of Automatic Control and Computer Science, Gheorghe Asachi Technical University of Iasi, 700050 Iasi, Romania. FAU - Petrescu-Miron, Diana AU - Petrescu-Miron D AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700588 Iasi, Romania. FAU - Visnevschi, Anatolie AU - Visnevschi A AUID- ORCID: 0000-0001-9664-7527 AD - Department of Laboratory Medicine, "Nicolae Testemitanu" State University of Medicine and Pharmacy, 165, Bd. Stefan cel Mare si Sfant, MD-2004 Chisinau, Moldova. AD - Research Center of Adipose Tissue Biology, "Nicolae Testemitanu" State University of Medicine and Pharmacy, 165, Bd. Stefan cel Mare si Sfant, MD-2004 Chisinau, Moldova. FAU - Vudu, Stela AU - Vudu S AUID- ORCID: 0000-0002-0377-9131 AD - Research Center of Adipose Tissue Biology, "Nicolae Testemitanu" State University of Medicine and Pharmacy, 165, Bd. Stefan cel Mare si Sfant, MD-2004 Chisinau, Moldova. AD - Department of Endocrinology, "Nicolae Testemitanu" State University of Medicine and Pharmacy, 165, Bd. Stefan cel Mare si Sfant, MD-2004 Chisinau, Moldova. FAU - Corciova, Calin AU - Corciova C AUID- ORCID: 0000-0002-0641-8323 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700588 Iasi, Romania. FAU - Fuior, Robert AU - Fuior R AUID- ORCID: 0000-0001-7067-7701 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700588 Iasi, Romania. FAU - Tupita, Nicoleta AU - Tupita N AD - Romanian Rugby Federation, 011468 Bucharest, Romania. FAU - Bouchard, Stephane AU - Bouchard S AUID- ORCID: 0000-0002-5995-340X AD - Departement de Psychologie et de Psychoeducation, Universite du Quebec en Outaouais, Gatineau, QC J8X 3X7, Canada. FAU - Mocanu, Veronica AU - Mocanu V AUID- ORCID: 0000-0002-9330-1691 AD - Grigore T. Popa University of Medicine and Pharmacy Iasi, 700588 Iasi, Romania. LA - eng GR - 1HARD/4.1/93/European Union/ PT - Journal Article DEP - 20251215 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adolescent MH - *Craving/physiology MH - Female MH - *Stress, Psychological/physiopathology/psychology MH - Male MH - *Electrocardiography MH - *Virtual Reality MH - *Feeding Behavior/psychology/physiology MH - *Food Preferences/psychology MH - Heart Rate MH - Surveys and Questionnaires MH - *Eating/psychology/physiology PMC - PMC12736307 OTO - NOTNLM OT - Trier Social Stress Test OT - adolescents OT - eating behavior OT - electrocardiogram (ECG) parameters OT - three-factor eating questionnaire (TFEQ) OT - virtual reality OT - virtual supermarket COIS- S.B. is president and owner of Clinique et Development In Virtuo, a spin-off company from his university that distributes virtual environments. The terms and arrangements for this spin-off have been reviewed and approved by the Universite du Quebec en Outaouais in accordance with its Conflict of Interest policies. He also receives honoraria from conferences, workshops, and books. The other authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/31 07:37 MHDA- 2025/12/31 07:38 PMCR- 2025/12/15 CRDT- 2025/12/31 01:05 PHST- 2025/09/30 00:00 [received] PHST- 2025/12/08 00:00 [revised] PHST- 2025/12/11 00:00 [accepted] PHST- 2025/12/31 07:38 [medline] PHST- 2025/12/31 07:37 [pubmed] PHST- 2025/12/31 01:05 [entrez] PHST- 2025/12/15 00:00 [pmc-release] AID - nu17243924 [pii] AID - nutrients-17-03924 [pii] AID - 10.3390/nu17243924 [doi] PST - epublish SO - Nutrients. 2025 Dec 15;17(24):3924. doi: 10.3390/nu17243924. PMID- 41470838 OWN - NLM STAT- MEDLINE DCOM- 20251231 LR - 20260926 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 24 DP - 2025 Dec 12 TI - SWITCHtoHEALTHY AI-Based Family Nutrition Recommendation System: Promoting the Mediterranean Diet. LID - 10.3390/nu17243892 [doi] LID - 3892 AB - Background/Objectives: Modern families face challenges in maintaining healthy and sustainable diets due to time constraints and busy lifestyles. The Mediterranean diet (MD), known for its benefits to both personal health and environmental sustainability, is often difficult to apply consistently within households. This paper presents and validates the SWITCHtoHEALTHY AI-based Family Nutrition Recommendation System, designed to generate meal plans aligned with MD guidelines. Methods: Two complementary recommendation engines were developed: the AI-based Family Nutritional Recommender, which creates personalized meal plans for adults that include shared family meals, and the Child Nutritional Recommender, which generates meal plans for children that could also incorporate school menus or proposals from the school cafeteria. Both systems rely on an expert-validated dataset of Mediterranean foods and are designed to comply with the expert-validated nutritional rules based on MD principals and national dietary guidelines. Results: The recommendation systems were validated using data from a real-world family intervention, achieving 90% accuracy in generating meal plans for all family members, while meeting the expert validated dietary rules for both adults and children. Moreover, AI-based Family Nutritional Recommender exceeds 90% accuracy in estimating calorie and nutrient content for adults. Conclusions: The results demonstrate the preliminary potential of AI-based recommendation systems to facilitate healthier and more sustainable dietary habits within modern households by generating personalized, nutritionally balanced family meal plans consistent with MD principles. FAU - Kalpakoglou, Kyriakos AU - Kalpakoglou K AUID- ORCID: 0009-0004-4117-0281 AD - Visual Computing Laboratory (VCL), Information Technologies Institute (ITI), Centre for Research and Technology Hellas (CERTH), 570 01 Thessaloniki, Greece. FAU - Degli Innocenti, Perla AU - Degli Innocenti P AUID- ORCID: 0000-0002-5678-4444 AD - Human Nutrition Unit, Department of Food and Drug, University of Parma, 43121 Parma, Italy. FAU - Bergamo, Federica AU - Bergamo F AUID- ORCID: 0009-0001-5351-5070 AD - Human Nutrition Unit, Department of Food and Drug, University of Parma, 43121 Parma, Italy. FAU - Beretta, Davide AU - Beretta D AUID- ORCID: 0000-0002-6694-9011 AD - Artificial Intelligence Laboratory, Department of Engineering for Industrial Systems and Technologies, University of Parma, 43121 Parma, Italy. FAU - Bergenti, Federico AU - Bergenti F AUID- ORCID: 0000-0002-4756-4765 AD - Artificial Intelligence Laboratory, Department of Engineering for Industrial Systems and Technologies, University of Parma, 43121 Parma, Italy. FAU - Rosi, Alice AU - Rosi A AUID- ORCID: 0000-0001-8533-797X AD - Human Nutrition Unit, Department of Food and Drug, University of Parma, 43121 Parma, Italy. FAU - Scazzina, Francesca AU - Scazzina F AUID- ORCID: 0000-0002-5372-8658 AD - Human Nutrition Unit, Department of Food and Drug, University of Parma, 43121 Parma, Italy. FAU - Calderon-Perez, Lorena AU - Calderon-Perez L AUID- ORCID: 0000-0003-0766-0733 AD - Technological Unit of Nutrition and Health, Eurecat, Technology Centre of Catalonia, 43204 Reus, Spain. FAU - Boque, Noemi AU - Boque N AUID- ORCID: 0000-0001-7173-5512 AD - Technological Unit of Nutrition and Health, Eurecat, Technology Centre of Catalonia, 43204 Reus, Spain. FAU - Guldas, Metin AU - Guldas M AUID- ORCID: 0000-0002-5187-9380 AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Bursa Uludag University, 16059 Bursa, Turkiye. FAU - Demir, Cagla Erdogan AU - Demir CE AUID- ORCID: 0000-0002-4281-0904 AD - Department of Biotechnology, Graduate School of Natural and Applied Sciences, Bursa Uludag University, 16059 Bursa, Turkiye. FAU - Gymnopoulos, Lazaros P AU - Gymnopoulos LP AUID- ORCID: 0000-0003-3310-102X AD - Visual Computing Laboratory (VCL), Information Technologies Institute (ITI), Centre for Research and Technology Hellas (CERTH), 570 01 Thessaloniki, Greece. FAU - Dimitropoulos, Kosmas AU - Dimitropoulos K AUID- ORCID: 0000-0003-1584-7047 AD - Visual Computing Laboratory (VCL), Information Technologies Institute (ITI), Centre for Research and Technology Hellas (CERTH), 570 01 Thessaloniki, Greece. LA - eng GR - 2133, project SWITCHtoHEALTHY/PRIMA Program/ PT - Journal Article DEP - 20251212 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - *Diet, Mediterranean MH - Humans MH - Child MH - Adult MH - *Nutrition Policy MH - *Artificial Intelligence MH - Meals MH - *Health Promotion/methods MH - Family MH - Female MH - Male MH - Feeding Behavior PMC - PMC12735497 OTO - NOTNLM OT - AI-based meal recommender OT - AI-based nutrition recommender OT - Mediterranean diet OT - artificial intelligence OT - children meal recommender OT - family diet OT - family meals OT - healthy diet COIS- The authors declare no conflicts of interest. EDAT- 2025/12/31 07:37 MHDA- 2025/12/31 07:38 PMCR- 2025/12/12 CRDT- 2025/12/31 01:04 PHST- 2025/11/10 00:00 [received] PHST- 2025/12/08 00:00 [revised] PHST- 2025/12/09 00:00 [accepted] PHST- 2025/12/31 07:38 [medline] PHST- 2025/12/31 07:37 [pubmed] PHST- 2025/12/31 01:04 [entrez] PHST- 2025/12/12 00:00 [pmc-release] AID - nu17243892 [pii] AID - nutrients-17-03892 [pii] AID - 10.3390/nu17243892 [doi] PST - epublish SO - Nutrients. 2025 Dec 12;17(24):3892. doi: 10.3390/nu17243892. PMID- 41470823 OWN - NLM STAT- MEDLINE DCOM- 20251231 LR - 20260103 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 24 DP - 2025 Dec 12 TI - Perspectives of Non-Medical Professionals Working in a Mental Health Service on Eating Disorders: Awareness, Knowledge, and Stigmatisation. LID - 10.3390/nu17243878 [doi] LID - 3878 AB - Background: Eating disorders (EDs) are serious mental health conditions often beginning in adolescence and are associated with significant morbidity and mortality. Although previous research has focused on medical staff, little is known about how EDs are recognised and managed by non-medical mental health professionals within community-based systems. This study examined their awareness, knowledge, and stigmatising beliefs toward EDs in Turkiye, highlighting implications for training and policy development. Methods: A study-specific questionnaire adapted from a validated tool previously used with general practitioners was administered to 42 non-medical professionals (95.2% female; mean age = 33.2 +/- 5.6 years) working in community mental health services in Ankara, Turkiye. Participants were randomly assigned to one of six clinical vignettes depicting a young person with anorexia nervosa (AN), bulimia nervosa, binge eating disorder, avoidant/restrictive food intake disorder (ARFID), depression, or type-1 diabetes. The questionnaire assessed illness perception, causal attributions, emotional reactions, professional knowledge, and stigmatising beliefs. Results: Only 28.6% (n = 12) correctly identified the disorder in their assigned vignette. BED had the highest diagnostic accuracy (50%), while AN and ARFID were most frequently misidentified. Participants commonly believed that EDs mainly affected females, had a short duration, and were less responsive to treatment. Stigmatising beliefs-such as personal blame-were also noted. Conclusions: Findings revealed limited awareness and knowledge of EDs-particularly AN and ARFID-among non-medical mental health professionals. Misconceptions that EDs are self-inflicted may delay recognition and referral. The results underscore the need for targeted education, anti-stigma interventions, and integration of ED content into professional training to improve early detection and community-based support. FAU - Ogutlu, Hakan AU - Ogutlu H AUID- ORCID: 0000-0002-1325-446X AD - Department of Child & Adolescent Psychiatry, Cognitive Behavioral Psychotherapies Association, Ankara 06680, Turkey. FAU - Tekeoglu, Ugur AU - Tekeoglu U AUID- ORCID: 0000-0002-8432-7566 AD - Department of Child & Adolescent Psychiatry, Faculty of Medicine, Recep Tayyip Erdogan University, Rize 53100, Turkey. FAU - McNicholas, Fiona AU - McNicholas F AUID- ORCID: 0000-0001-9428-6908 AD - Department of Child & Adolescent Psychiatry, School of Medicine and Medical Science, University College Dublin, D04 V1W8 Dublin, Ireland. LA - eng GR - Grant number to be assigned./Recep Tayyip Erdogan University/ PT - Journal Article DEP - 20251212 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Adult MH - *Feeding and Eating Disorders/psychology/diagnosis/therapy MH - *Health Knowledge, Attitudes, Practice MH - Male MH - Surveys and Questionnaires MH - *Social Stigma MH - *Health Personnel/psychology MH - *Mental Health Services MH - Attitude of Health Personnel MH - Middle Aged MH - Young Adult MH - Awareness MH - Stereotyping PMC - PMC12736076 OTO - NOTNLM OT - Turkiye OT - awareness OT - eating disorders OT - non-medical professionals OT - stigma OT - training COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. EDAT- 2025/12/31 07:37 MHDA- 2025/12/31 07:38 PMCR- 2025/12/12 CRDT- 2025/12/31 01:04 PHST- 2025/09/02 00:00 [received] PHST- 2025/10/05 00:00 [revised] PHST- 2025/10/23 00:00 [accepted] PHST- 2025/12/31 07:38 [medline] PHST- 2025/12/31 07:37 [pubmed] PHST- 2025/12/31 01:04 [entrez] PHST- 2025/12/12 00:00 [pmc-release] AID - nu17243878 [pii] AID - nutrients-17-03878 [pii] AID - 10.3390/nu17243878 [doi] PST - epublish SO - Nutrients. 2025 Dec 12;17(24):3878. doi: 10.3390/nu17243878. PMID- 41470795 OWN - NLM STAT- MEDLINE DCOM- 20251231 LR - 20260103 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 24 DP - 2025 Dec 10 TI - Dietary Inflammatory Potential and Sociodemographic Correlates Among Adults in Saudi Arabia: A Cross-Sectional Study. LID - 10.3390/nu17243851 [doi] LID - 3851 AB - Background: Dietary patterns influence systemic inflammation, which is involved in the pathogenesis of non-communicable diseases. The dietary inflammatory index (DII) quantifies the inflammatory potential of the diet and varies across populations due to cultural and regional eating habits. Limited data exist on the inflammatory potential of diets in Saudi Arabia. This study aimed to assess the inflammatory potential of the diet and its association with sociodemographic and lifestyle factors among adults in Saudi Arabia. Methods: A cross-sectional study included 256 adults aged 18-50 years residing in Saudi Arabia. Participants were recruited using convenience sampling via social media platforms. Data were collected between November 2024 and August 2025 using a validated Saudi food frequency questionnaire and sociodemographic survey. Energy-adjusted DII (E-DII) scores were calculated using 42 food parameters. Non-parametric tests (Mann-Whitney U and Kruskal-Wallis) were applied to examine associations between E-DII and sociodemographic variables. Results: Significant differences in E-DII were observed by sex (p < 0.001). Males had higher E-DII scores than females, suggesting more pro-inflammatory diets. Participants with postgraduate education tended to have lower E-DII than participants with only a high school degree, reflecting more anti-inflammatory dietary patterns. However, this trend was not statistically significant (p = 0.06). The mean E-DII was 4.8 +/- 1.3, indicating a predominantly pro-inflammatory dietary pattern. No significant differences were found across age, education, income, BMI, marital status, employment, or smoking status. Conclusions: Sex was a key determinant of dietary inflammatory potential. Adults demonstrated overall pro-inflammatory dietary patterns in Saudi Arabia. Public health interventions should target higher risk groups, such as males with a higher risk of non-communicable diseases, to promote anti-inflammatory dietary habits and reduce chronic disease risk in this population. FAU - Asiri, Raneem AU - Asiri R AD - Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia. FAU - Alashmali, Shoug AU - Alashmali S AUID- ORCID: 0000-0001-5675-2832 AD - Department of Clinical Nutrition, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah 21589, Saudi Arabia. LA - eng PT - Journal Article DEP - 20251210 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Adult MH - Saudi Arabia/epidemiology MH - Male MH - Female MH - Cross-Sectional Studies MH - Middle Aged MH - Young Adult MH - *Inflammation/epidemiology/etiology MH - *Diet/adverse effects/statistics & numerical data MH - Adolescent MH - Sociodemographic Factors MH - *Feeding Behavior MH - Sex Factors MH - Socioeconomic Factors MH - Life Style PMC - PMC12736128 OTO - NOTNLM OT - Saudi Arabia OT - adults OT - diet OT - inflammation OT - sociodemographic COIS- The authors declare no conflicts of interest. EDAT- 2025/12/31 07:37 MHDA- 2025/12/31 07:38 PMCR- 2025/12/10 CRDT- 2025/12/31 01:04 PHST- 2025/10/31 00:00 [received] PHST- 2025/12/02 00:00 [revised] PHST- 2025/12/06 00:00 [accepted] PHST- 2025/12/31 07:38 [medline] PHST- 2025/12/31 07:37 [pubmed] PHST- 2025/12/31 01:04 [entrez] PHST- 2025/12/10 00:00 [pmc-release] AID - nu17243851 [pii] AID - nutrients-17-03851 [pii] AID - 10.3390/nu17243851 [doi] PST - epublish SO - Nutrients. 2025 Dec 10;17(24):3851. doi: 10.3390/nu17243851. PMID- 41470760 OWN - NLM STAT- MEDLINE DCOM- 20251231 LR - 20260103 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 24 DP - 2025 Dec 5 TI - Orthorexia Profiles in Athletes: A Multidimensional Analysis Using the Eating Habits Questionnaire (EHQ) and the Teruel Orthorexia Scale (TOS). LID - 10.3390/nu17243814 [doi] LID - 3814 AB - Background: Orthorexia nervosa (OrNe) and healthy orthorexia (HeOr) are two distinct but related dimensions of interest in eating behavior research. Evidence regarding their associations with sociodemographic, dietary, and sport-related variables in physically active young adults remains limited. Methods: A cross-sectional study was conducted in 190 physically active young adults (53.2% women; mean age = 23.16 +/- 5.13 years). Participants practiced a variety of sports including fitness (25.3%), soccer (13.7%), handball (10.5%), athletics, martial arts, cycling, and other individual or team sports. Although all participants belonged to organized sports teams or structured training groups, 38.9% were not actively competing at the time of data collection. Participants completed validated instruments assessing OrNe, HeOr, and eating-related cognitions, alongside questionnaires on sociodemographic data, dietary habits, sport discipline, training frequency, and supplement use. Hierarchical and K-means clustering were applied using the standardized scores of HeOr, OrNe, and the EHQ total score. Group differences were assessed using t-tests and ANOVA with effect sizes (eta(2)p) reported. Results: Age correlated positively with OrNe, HeOr, and eating-related cognitions, indicating greater consolidation of rigid eating patterns in young adulthood. BMI was associated with OrNe only among men. Vegetarian participants showed higher nutritional knowledge but lower overall orthorexia scores. Supplement users in fitness-related sports reported higher OrNe, whereas participants in collective sports reported lower scores. Three distinct orthorexia profiles were identified, characterized by lower, slightly above-average, and higher scores on orthorexia-related variables. Participants in the higher-scoring profile showed significantly higher EHQ total, OrNe, and HeOr scores compared with the other groups (eta(2)p range = 0.11-0.19). Correlations among orthorexia dimensions were positive and moderate to large. Differences between clusters in sport modality, training frequency, and supplement use underscored the influence of the sporting context. Conclusions: Orthorexia in young physically active adults reflects heterogeneous patterns shaped by the interplay of individual (age, sex, BMI), dietary, and sport-related factors. The identification of differentiated profiles reinforces the multidimensional nature of orthorexia and underscores the relevance of considering specific sport environments when interpreting orthorexic tendencies. Longitudinal research is warranted to examine the stability or variability of these patterns over time and to enable the use of more robust multivariate approaches that further clarify the characterization of orthorexia. FAU - Manzanares-Cabrera, Maria AU - Manzanares-Cabrera M AD - Hospital Quiron Health Ciudad Real, 13002 Ciudad Real, Spain. FAU - Onieva-Zafra, Maria Dolores AU - Onieva-Zafra MD AUID- ORCID: 0000-0002-1052-2182 AD - Department of Nursing, Physiotherapy and Occupational Therapy, Ciudad Real Faculty of Nursing, University of Castilla-La Mancha, 13071 Ciudad Real, Spain. AD - Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), Castilla-La Mancha, 45004 Toledo, Spain. FAU - Bermejo-Cantarero, Alberto AU - Bermejo-Cantarero A AUID- ORCID: 0000-0001-6463-5556 AD - Department of Nursing, Physiotherapy and Occupational Therapy, Ciudad Real Faculty of Nursing, University of Castilla-La Mancha, 13071 Ciudad Real, Spain. AD - Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), Castilla-La Mancha, 45004 Toledo, Spain. AD - Centro de Estudios Sociosanitarios (CESS), University of Castilla-La Mancha, 13071 Cuenca, Spain. FAU - Exposito-Gonzalez, Raul AU - Exposito-Gonzalez R AUID- ORCID: 0000-0003-1481-4251 AD - Department of Nursing, Physiotherapy and Occupational Therapy, Ciudad Real Faculty of Nursing, University of Castilla-La Mancha, 13071 Ciudad Real, Spain. AD - Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), Castilla-La Mancha, 45004 Toledo, Spain. FAU - Lerma-Garcia, Daniel AU - Lerma-Garcia D AUID- ORCID: 0009-0000-0460-0933 AD - Department of Nursing, University of Illes Balears, Ibiza, Baleares, 07800 Ibiza, Spain. FAU - Parra-Fernandez, Maria Laura AU - Parra-Fernandez ML AUID- ORCID: 0000-0001-9681-1737 AD - Department of Nursing, Physiotherapy and Occupational Therapy, Ciudad Real Faculty of Nursing, University of Castilla-La Mancha, 13071 Ciudad Real, Spain. AD - Instituto de Investigacion Sanitaria de Castilla-La Mancha (IDISCAM), Castilla-La Mancha, 45004 Toledo, Spain. LA - eng PT - Journal Article DEP - 20251205 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Female MH - *Feeding Behavior/psychology MH - Cross-Sectional Studies MH - Young Adult MH - *Athletes/psychology MH - *Feeding and Eating Disorders/psychology/diagnosis MH - Surveys and Questionnaires MH - Adult MH - Adolescent MH - Sports/psychology MH - Health Behavior PMC - PMC12735428 OTO - NOTNLM OT - cluster analysis OT - dietary patterns OT - healthy orthorexia OT - orthorexia nervosa OT - sports OT - supplements OT - young adults COIS- The authors declare no conflicts of interest. EDAT- 2025/12/31 07:37 MHDA- 2025/12/31 07:38 PMCR- 2025/12/05 CRDT- 2025/12/31 01:04 PHST- 2025/10/31 00:00 [received] PHST- 2025/12/02 00:00 [revised] PHST- 2025/12/03 00:00 [accepted] PHST- 2025/12/31 07:38 [medline] PHST- 2025/12/31 07:37 [pubmed] PHST- 2025/12/31 01:04 [entrez] PHST- 2025/12/05 00:00 [pmc-release] AID - nu17243814 [pii] AID - nutrients-17-03814 [pii] AID - 10.3390/nu17243814 [doi] PST - epublish SO - Nutrients. 2025 Dec 5;17(24):3814. doi: 10.3390/nu17243814. PMID- 41470756 OWN - NLM STAT- MEDLINE DCOM- 20251231 LR - 20260103 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 24 DP - 2025 Dec 5 TI - FFQ-NutriForHer: Reproducibility and Validity of a Semi-Quantitative Food Frequency Questionnaire for Young and Older Women. LID - 10.3390/nu17243811 [doi] LID - 3811 AB - Background: Despite the growing interest in the relationship of diet and women's health conditions, a limited number of Food Frequency Questionnaires (FFQs) have been specifically developed and/or validated for use among women, and those that exist have been primarily developed and validated in non-European countries. This study aimed to evaluate the reproducibility and validity of the FFQ-NutriForHer among young and older Polish women. Methods: The reproducibility and validity of the 138-item FFQ-NutriForHer were evaluated in 121 young (18-30 years) and 88 older women (70-90 years). Reproducibility was assessed using energy-adjusted Pearson and intraclass correlation coefficients (PCCs, ICCs) from two FFQ administrations. Validity was evaluated by comparing energy-adjusted and de-attenuated PCCs between FFQ-mean and 3-day dietary records. The Bland-Altman method estimated mean differences and limits of agreement. Results: The mean PCCs and ICCs for macronutrient reproducibility were 0.69 +/- 0.12 and 0.69 +/- 0.11 among young women and 0.67 +/- 0.06 and 0.65 +/- 0.11 among older women, respectively, indicating moderate correlation and reliability in both groups. For micronutrients, the mean PCCs were 0.72 +/- 0.05 among young women and 0.69 +/- 0.05 among older women, while ICCs were 0.71 +/- 0.05 and 0.69 +/- 0.09, respectively, indicating a good and moderate correlation and moderate reliability. Mean PCCs for macronutrient validity indicated good concordance with values of 0.51 +/- 0.25 among young women and 0.46 +/- 0.13 among older women. For micronutrients, the mean PCC for validity was 0.63 +/- 0.13 among young women and 0.44 +/- 0.14 among older women. Bland-Altman analysis indicated good overall agreement between methods in both groups. Conclusions: Given its high reproducibility and satisfactory validity in both age groups, the FFQ-NutriForHer is a reliable tool for assessing dietary intake and exploring its links to women's health across different ages. FAU - Szmidt, Maria Karolina AU - Szmidt MK AUID- ORCID: 0000-0001-6970-1671 AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Nowoursynowska 166, 02-787 Warsaw, Poland. FAU - Sicinska, Ewa AU - Sicinska E AUID- ORCID: 0000-0001-7187-319X AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Nowoursynowska 166, 02-787 Warsaw, Poland. FAU - Januszko, Olga AU - Januszko O AUID- ORCID: 0000-0002-4768-4812 AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Nowoursynowska 166, 02-787 Warsaw, Poland. FAU - Kaluza, Joanna AU - Kaluza J AUID- ORCID: 0000-0001-9454-0929 AD - Department of Human Nutrition, Institute of Human Nutrition Sciences, Warsaw University of Life Sciences (WULS-SGGW), Nowoursynowska 166, 02-787 Warsaw, Poland. LA - eng GR - n/a/Science Development Fund of the Warsaw University of Life Sciences - SGGW/ GR - n/a/Polish Ministry of Science and Higher Education with funds from the Institute of Human Nutri-tion Sciences, Warsaw University of Life Sciences (WULS)/ PT - Journal Article PT - Validation Study DEP - 20251205 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - Reproducibility of Results MH - Aged MH - Adult MH - Young Adult MH - Adolescent MH - Aged, 80 and over MH - Surveys and Questionnaires/standards MH - *Diet Surveys/methods MH - *Diet MH - Poland MH - *Nutrition Assessment MH - Diet Records PMC - PMC12735852 OTO - NOTNLM OT - FFQ OT - diet assessment OT - reproducibility OT - validity OT - women COIS- The authors declare no conflicts of interest. EDAT- 2025/12/31 07:37 MHDA- 2025/12/31 07:38 PMCR- 2025/12/05 CRDT- 2025/12/31 01:04 PHST- 2025/10/30 00:00 [received] PHST- 2025/11/28 00:00 [revised] PHST- 2025/12/02 00:00 [accepted] PHST- 2025/12/31 07:38 [medline] PHST- 2025/12/31 07:37 [pubmed] PHST- 2025/12/31 01:04 [entrez] PHST- 2025/12/05 00:00 [pmc-release] AID - nu17243811 [pii] AID - nutrients-17-03811 [pii] AID - 10.3390/nu17243811 [doi] PST - epublish SO - Nutrients. 2025 Dec 5;17(24):3811. doi: 10.3390/nu17243811. PMID- 41469736 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 2050-7283 (Electronic) IS - 2050-7283 (Linking) VI - 14 IP - 1 DP - 2025 Dec 30 TI - The dual links of health literacy in driving exercise adherence: the interactive effects of emotional management ability and life satisfaction. PG - 143 LID - 10.1186/s40359-025-03889-1 [doi] LID - 143 AB - OBJECTIVE: Based on the Health Action Process Approach theory, this study aims to explore how health literacy influences exercise adherence among Chinese university students. It focuses on examining the chain mediating effects of emotional management ability and life satisfaction. METHOD: This study used a stratified, cluster, and phased sampling approach to gather demographic information. Data were collected through the Wenjuanxing platform. The survey gathered information on health literacy, emotional management ability, life satisfaction, and exercise adherence among university students. A total of 11,272 valid questionnaires were collected. RESULTS: Health literacy directly predicted exercise adherence positively (beta = 0.618, P < 0.001). Emotional management Ability (effect size = 0.281, 95% CI = [0.254, 0.308]) and life satisfaction (effect size = 0.054, 95% CI = [0.044, 0.065]) both served as independent mediators. Life satisfaction also emerged as a significant, albeit relatively small, independent mediator. The chain mediation path of health literacy --> emotional management ability --> life satisfaction --> exercise adherence was significant (effect size = 0.061, 95% CI = [0.051, 0.071]). CONCLUSION: Health literacy not only directly promotes exercise adherence among Chinese university students but also exerts an indirect effect through the chain mechanism of improved emotional management ability and enhanced life satisfaction. This finding validates the progressive cognitive-affective-behavioral pathway in the Health Action Process Approach theory. Future interventions should integrate health education, emotional management ability training, and life satisfaction enhancement strategies. This approach will systematically optimize the long-term maintenance of exercise behaviors. FAU - Zhang, Wen-Hao AU - Zhang WH AD - Institute of Sports Science, Nantong University, Nantong, 226019, China. FAU - Han, Shan-Shan AU - Han SS AD - Institute of Sports Science, Nantong University, Nantong, 226019, China. FAU - Lou, Hu AU - Lou H AD - Institute of Sports Science, Nantong University, Nantong, 226019, China. FAU - Qian, Yu-Yan AU - Qian YY AD - Journal Publishing Center, Nantong University, Nantong, 226019, China. FAU - Li, Bo AU - Li B AD - Institute of Sports Science, Nantong University, Nantong, 226019, China. wangqiulibo@163.com. FAU - Xu, Ling-Li AU - Xu LL AD - Institute of Sports Science, Nantong University, Nantong, 226019, China. 853314539@qq.com. LA - eng GR - No. 2025SJZD143/2025 Major Project of Philosophy and Social Science Research in Colleges and Universities: Research on the Formation Mechanism and Exercise Intervention of College Students' Mental Health Problems in the Era of Digital Intelligence/ PT - Journal Article DEP - 20251230 PL - England TA - BMC Psychol JT - BMC psychology JID - 101627676 SB - IM MH - Humans MH - Female MH - *Personal Satisfaction MH - *Exercise/psychology MH - Male MH - *Health Literacy MH - Young Adult MH - Adult MH - *Students/psychology/statistics & numerical data MH - China MH - *Emotional Regulation MH - Universities MH - Adolescent MH - Surveys and Questionnaires MH - Emotions PMC - PMC12866430 OTO - NOTNLM OT - Chinese university students OT - Emotional management ability OT - Exercise adherence OT - Health action process approach theory OT - Health literacy OT - Life satisfaction OT - Mediation analysis OT - Psychological mechanism COIS- Declarations. Ethics approval and consent to participate: Informed consent was obtained from all the subjects involved in the study. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/31 00:33 MHDA- 2026/06/27 00:51 PMCR- 2025/12/30 CRDT- 2025/12/30 23:36 PHST- 2025/09/10 00:00 [received] PHST- 2025/12/17 00:00 [accepted] PHST- 2026/06/27 00:51 [medline] PHST- 2025/12/31 00:33 [pubmed] PHST- 2025/12/30 23:36 [entrez] PHST- 2025/12/30 00:00 [pmc-release] AID - 10.1186/s40359-025-03889-1 [pii] AID - 3889 [pii] AID - 10.1186/s40359-025-03889-1 [doi] PST - epublish SO - BMC Psychol. 2025 Dec 30;14(1):143. doi: 10.1186/s40359-025-03889-1. PMID- 41469636 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2025 Dec 30 TI - Promoting healthy lifestyles in childhood: can a social media campaign targeting parents and carers be a valuable tool? PG - 412 LID - 10.1186/s12889-025-26054-0 [doi] LID - 412 AB - BACKGROUND: Social media can have a profound impact on population health and should be considered an important determinant of health. No published studies have assessed the potential of Social Media Campaigns (SMCs) as public health tools to address lifestyle behaviours in school-aged children. The aims of this study were to assess the performance of a health promotion SMC targeting parents and carers, compare its cost and reach with a print-based health communication campaign, and document audience responses to the SMC topics. METHODS: During a 9-month long SMC promoting healthy lifestyles in primary school children, communication materials on the importance of healthy eating habits, physical activity, and of reducing sedentary lifestyles, were posted on Facebook and Instagram. Online social media Key Performance Indicators were used to analyse the SMC within the context of health promotion; costs were defined as expenditures for sponsorship and management of the SMC and for printing and distributing materials for the print-based health communication campaign; a qualitative analysis was carried out to examinate the comments posted by users. RESULTS: The SMC reached 1,366,287 accounts and generated 1,791,458 impressions, mostly through sponsored posts. Although the overall budget for the SMC was 2.2 times higher than the one spent for the print-based health communication campaign, the SMC reached almost 27 times more people. Qualitative analysis showed 78% of comments moderately-strongly agreed with the Campaign's recommendations. Most comments recognized the importance of proper nutrition and an active lifestyle in children, although several users expressed concerns regarding the feasibility of the recommendations. CONCLUSIONS: The findings of this study suggest that social media can be used to convey information on topics of public health concern, thanks to its potential to reach large portions of the population, at a fraction of the cost of print-based health communication campaigns. Our results support the hypothesis that a SMC can be a useful tool to disseminate information regarding healthy lifestyles in school-aged children, with the aim of improving knowledge on nutrition and physical activity among parents and carers. More research is needed to assess the effectiveness of SMCs in changing children's lifestyles and parents' attitudes. FAU - Cattaneo, Chiara AU - Cattaneo C AD - National Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy Viale Regina Elena 299, Roma, 00161, Italy. FAU - Pani, Paola AU - Pani P AD - Clinical Epidemiology and Public Health Research Unit. Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Via Dell'Istria 65/1, Trieste, 34137, Italy. FAU - Palermo, Vittorio AU - Palermo V AD - National Centre for Disease Prevention and Health Promotion, National Institute of Health, Rome, Italy Viale Regina Elena 299, Roma, 00161, Italy. FAU - Maurel, Eleonora AU - Maurel E AD - Clinical Epidemiology and Public Health Research Unit. Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Via Dell'Istria 65/1, Trieste, 34137, Italy. eleonora.maurel@burlo.trieste.it. FAU - Knowles, Alessandra AU - Knowles A AD - Clinical Epidemiology and Public Health Research Unit. Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Via Dell'Istria 65/1, Trieste, 34137, Italy. FAU - Carletti, Claudia AU - Carletti C AD - Clinical Epidemiology and Public Health Research Unit. Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Via Dell'Istria 65/1, Trieste, 34137, Italy. CN - BIGdagger group LA - eng PT - Journal Article DEP - 20251230 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Health Promotion/methods/economics MH - *Social Media MH - Child MH - *Healthy Lifestyle MH - *Parents/psychology MH - *Caregivers/psychology MH - Male MH - Female MH - Exercise PMC - PMC12859976 OTO - NOTNLM OT - Campaign OT - Health promotion OT - Healthy eating habits OT - Physical activity OT - Public health tool OT - School-aged children OT - Sedentary lifestyles OT - Social media COIS- Declarations. Ethics approval and consent to participate: The protocol of the national CCM 2018 project was formally approved by the Regional Ethics Committee of Friuli Venezia Giulia (ARCS GEN/ARCS n.28178 del 27/09/2019). The research was conducted in accordance with the Declaration of Helsinki. Electronic informed consent to participate to the study was provided by all participants prior to filling in the questionnaires. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. FIR - Buoncristiano, Marta IR - Buoncristiano M FIR - De Mei, Barbara IR - De Mei B FIR - Dittami, Arianna IR - Dittami A FIR - Donati, Serena IR - Donati S FIR - Fantozzi, Lorenzo IR - Fantozzi L FIR - Luzi, Ilaria IR - Luzi I FIR - Luzi, Paola IR - Luzi P FIR - Nardone, Paola IR - Nardone P FIR - Sampaolo, Letizia IR - Sampaolo L FIR - Scardetta, Paola IR - Scardetta P FIR - Ronfani, Luca IR - Ronfani L FIR - Caputo, Marcello IR - Caputo M FIR - Cardetti, Silvia IR - Cardetti S FIR - Devalle, Pietro Luigi IR - Devalle PL FIR - Gorrasi, Ilaria Silvia Rossella IR - Gorrasi ISR FIR - Rapalino, Paola IR - Rapalino P FIR - Sacchi, Elena IR - Sacchi E FIR - Cairella, Giulia IR - Cairella G FIR - Giliberti, Cristina IR - Giliberti C FIR - Olivieri, Luciana IR - Olivieri L FIR - Apasciuto, Vittoria IR - Apasciuto V FIR - Ceccarelli, Maria Teresa IR - Ceccarelli MT FIR - Cuoco, Iolanda IR - Cuoco I FIR - D Agnese, Paola IR - D Agnese P FIR - Iavarone, Fabio IR - Iavarone F FIR - Rabbito, Vincenza IR - Rabbito V FIR - Vairano, Maria Paola IR - Vairano MP FIR - Carotenuto, Michele IR - Carotenuto M FIR - De Simone, Giuseppina IR - De Simone G FIR - Grazioli, Ciro IR - Grazioli C FIR - Imoletti, Maria IR - Imoletti M FIR - Mastantuono, Teresa IR - Mastantuono T FIR - Mazzarella, Gianfranco IR - Mazzarella G FIR - Monsurro, Pasqualina IR - Monsurro P FIR - Pecoraro, Pierluigi IR - Pecoraro P FIR - Sensi, Serena IR - Sensi S FIR - Serrapica, Raffaella IR - Serrapica R FIR - Sorrentino, Carmelina IR - Sorrentino C FIR - Tanzillo, Maria IR - Tanzillo M FIR - Fedele, Roberta IR - Fedele R FIR - Fontana, Federico IR - Fontana F FIR - Locci, Mirco IR - Locci M FIR - Longo, Tiziana IR - Longo T FIR - Marin, Louise IR - Marin L FIR - Occoni, Emanuela IR - Occoni E FIR - Pahor, Alessandra IR - Pahor A FIR - Verrone, Cristina IR - Verrone C FIR - Dri, Pietro IR - Dri P FIR - Valetto, Maria Rosa IR - Valetto MR FIR - Menzano, Maria Teresa IR - Menzano MT FIR - Olivieri, Bruno IR - Olivieri B FIR - Trippa, Elisabetta IR - Trippa E FIR - Simoni, Lorenzo IR - Simoni L EDAT- 2025/12/31 00:33 MHDA- 2026/06/27 00:58 PMCR- 2025/12/30 CRDT- 2025/12/30 23:30 PHST- 2024/08/08 00:00 [received] PHST- 2025/12/17 00:00 [accepted] PHST- 2026/06/27 00:58 [medline] PHST- 2025/12/31 00:33 [pubmed] PHST- 2025/12/30 23:30 [entrez] PHST- 2025/12/30 00:00 [pmc-release] AID - 10.1186/s12889-025-26054-0 [pii] AID - 26054 [pii] AID - 10.1186/s12889-025-26054-0 [doi] PST - epublish SO - BMC Public Health. 2025 Dec 30;26(1):412. doi: 10.1186/s12889-025-26054-0. PMID- 41469307 OWN - NLM STAT- MEDLINE DCOM- 20260323 LR - 20260323 IS - 1873-5010 (Electronic) IS - 1569-1993 (Linking) VI - 25 IP - 2 DP - 2026 Mar TI - The impact of telehealth on clinical outcomes in adults and children with cystic fibrosis in Australia. PG - 369-374 LID - S1569-1993(25)02548-2 [pii] LID - 10.1016/j.jcf.2025.12.017 [doi] AB - BACKGROUND: Telehealth has been widely incorporated into cystic fibrosis (CF) care in Australia and other countries, with a largely hybrid approach of multidisciplinary telehealth alongside traditional in-person care. While feasibility and acceptability of telehealth-based care has been established, the impact on CF-related health outcomes has not been comprehensively assessed. METHODS: Retrospective cohort study using national Australian Cystic Fibrosis Registry Data (ACFDR). Primary outcomes were change in percent predicted forced expiratory volume in one second (ppFEV(1)) in adults and body mass index (BMI) z-score in children. Secondary outcomes included lung function, BMI, microbiology and hospital admissions. Telehealth use was stratified according to percentage of telehealth visits out of total CF clinic visits during the study period, examined as quartiles. Analyses were conducted using Analysis of Covariance (ANCOVA) and logistic regression, to isolate the effect of telehealth use quartile on outcomes after adjusting for confounders. RESULTS: Complete data from 1250 patients, (646 < 18 yr, 594 >/= 18 yrs), were analysed. There was less decline in ppFEV(1) in adults (beta = 6.06, p < 0.001), and lower detection of Pseudomonas aeruginosa in adults (OR = 0.419, p = 0.035) and children (OR = 0.182, p = 0.011) who received greater than 75% of visits via telehealth. However, high telehealth use was associated with reduced microbiological sampling. Telehealth was not associated with change in BMI or hospitalisations. CONCLUSIONS: Population level data from the ACFDR demonstrates that higher telehealth usage was not associated with adverse health outcomes and was associated with a reduced decline in ppFEV(1) in adults. CI - Copyright (c) 2025. Published by Elsevier B.V. FAU - Douglas, Tonia A AU - Douglas TA AD - Department of Respiratory and Sleep Medicine, Queensland Children's Hospital, South Brisbane, Queensland, Australia; Clinical Unit, Faculty of Medicine, University of Queensland, St Lucia, Queensland, Australia. Electronic address: Tonia.Douglas@health.qld.gov.au. FAU - Pourghaderi, Ahmad Reza AU - Pourghaderi AR AD - School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. FAU - Ahern, Susannah AU - Ahern S AD - School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. FAU - Corda, Jen AU - Corda J AD - Department of Physiotherapy, Royal Children's Hospital, Parkville, Victoria, Australia. FAU - Earnest, Arul AU - Earnest A AD - School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. FAU - Mulrennan, Siobhain AU - Mulrennan S AD - Department of Respiratory Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia; Institute for Respiratory Health, University of Western Australia, Nedlands, Western Australia, Australia. FAU - Ranganathan, Sarath AU - Ranganathan S AD - Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Parkville, Victoria, Australia; Respiratory Diseases, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia. FAU - Ruseckaite, Rasa AU - Ruseckaite R AD - School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. FAU - Shanthikumar, Shivanthan AU - Shanthikumar S AD - Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Parkville, Victoria, Australia; Respiratory Diseases, Murdoch Children's Research Institute, Parkville, Victoria, Australia; Department of Paediatrics, University of Melbourne, Parkville, Victoria, Australia. LA - eng PT - Journal Article DEP - 20251230 PL - Netherlands TA - J Cyst Fibros JT - Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society JID - 101128966 SB - IM MH - Humans MH - *Cystic Fibrosis/therapy/physiopathology/epidemiology/diagnosis MH - *Telemedicine/statistics & numerical data MH - Male MH - Australia/epidemiology MH - Female MH - Adult MH - Retrospective Studies MH - Child MH - Adolescent MH - Body Mass Index MH - Respiratory Function Tests/methods MH - Registries MH - Forced Expiratory Volume MH - Pseudomonas Infections/epidemiology MH - Young Adult OTO - NOTNLM OT - Adults OT - Children OT - Cystic fibrosis OT - Health outcomes OT - Hospitalisations OT - Lung function OT - Nutrition OT - Telehealth COIS- Declaration of competing interest TD, SS, received honoraria paid into their institutions from Vertex Pharmaceuticals for educational events, grants (SS), and consultancy. AP, SA, JC, SM, SR, AE and RR have no conflicts of interest. EDAT- 2025/12/31 00:33 MHDA- 2026/03/23 06:31 CRDT- 2025/12/30 22:29 PHST- 2025/08/01 00:00 [received] PHST- 2025/11/23 00:00 [revised] PHST- 2025/12/22 00:00 [accepted] PHST- 2026/03/23 06:31 [medline] PHST- 2025/12/31 00:33 [pubmed] PHST- 2025/12/30 22:29 [entrez] AID - S1569-1993(25)02548-2 [pii] AID - 10.1016/j.jcf.2025.12.017 [doi] PST - ppublish SO - J Cyst Fibros. 2026 Mar;25(2):369-374. doi: 10.1016/j.jcf.2025.12.017. Epub 2025 Dec 30. PMID- 41469055 OWN - NLM STAT- MEDLINE DCOM- 20251230 LR - 20260106 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 12 DP - 2025 Dec 29 TI - Methodological considerations and cost to measure coverage of multisectoral nutrition interventions: protocol for the One Nutrition Coverage Survey in Bangladesh. PG - e099314 LID - 10.1136/bmjopen-2025-099314 [doi] LID - e099314 AB - INTRODUCTION: Despite global commitments to eliminate malnutrition, over half the world's population remains affected. Multisectoral nutrition interventions targeting both proximate and distal causes of malnutrition are essential across the lifespan. Yet, current data collection lacks comprehensive nutrition intervention coverage measures, risking inaccuracies in tracking progress. The One Nutrition Coverage Survey (ONCS) aims to test new and refined coverage measurement methods, assess coverage equity and guide integration into large-scale household surveys. METHODS AND ANALYSIS: The ONCS will be a cross-sectional, population-representative household survey conducted in four districts of Bangladesh (Rangpur, Sylhet, Dhaka and Khulna), selected for their geographic spread and urban-rural balance. A stratified multistage sampling approach will be used to select enumeration areas, and a total of approximately 3280 households randomly selected within each EA will be included in the survey. The survey will interview women of reproductive age (15-49 years), caregivers of children (0-9 years), adolescents (10-19 years) and pregnant women, collecting data on multisectoral nutrition interventions relevant to these groups. It will use both existing and new measures, while also capturing monetary and non-monetary costs for survey design to implementation. Data will be analysed to assess coverage, co-coverage and equity by sociodemographic characteristics, as well as the feasibility, accuracy and costs of the survey approach. ETHICS AND DISSEMINATION: The study protocol and instruments were reviewed and approved by the International Centre for Diarrhoeal Disease Research, Bangladesh's (icddr,b) Ethical Review Board in Bangladesh and the International Food Policy Research Institute's Institutional Review Board in Washington, DC, USA. Adults provided signed informed consent and adolescents their assent. Findings will be shared through peer-reviewed publications, conferences and presentations in Bangladesh with key stakeholders. This study will yield new tools, methods and evidence for measuring multisectoral nutrition intervention coverage, applicable to other low-income and middle-income countries. Learnings from ONCS will enhance data collection aligned with national strategies, helping governments improve coverage assessments, inform decisions and strengthen programme monitoring. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group. FAU - Manohar, Swetha AU - Manohar S AUID- ORCID: 0000-0003-4042-8952 AD - Nutrition, Diets and Health, International Food Policy Research Institute, Washington, District of Columbia, USA s.manohar@cgiar.org. FAU - Nguyen, Phuong Hong AU - Nguyen PH AUID- ORCID: 0000-0003-3418-1674 AD - Nutrition, Diets and Health, International Food Policy Research Institute, Washington, District of Columbia, USA. FAU - Neupane, Sumanta AU - Neupane S AUID- ORCID: 0000-0003-2977-0896 AD - Nutrition, Diets, and Health, International Food Policy Research Institute, Kathmandu, Nepal. FAU - Munos, Melinda Kay AU - Munos MK AUID- ORCID: 0000-0002-1349-8026 AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Heidkamp, Rebecca AU - Heidkamp R AD - Department of International Health, Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland, USA. FAU - Banerjee, Archis AU - Banerjee A AUID- ORCID: 0000-0002-0831-304X AD - Nutrition, Diets, and Health, International Food Policy Research Institute, Dhaka, Bangladesh. FAU - Pandya, Niharika AU - Pandya N AD - Nutrition, Diets and Health, International Food Policy Research Institute, New Delhi, India. FAU - Kim, Sunny S AU - Kim SS AD - International Food Policy Research Institute Poverty Health and Nutrition Division, Washington, District of Columbia, USA. LA - eng PT - Journal Article DEP - 20251229 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Bangladesh/epidemiology MH - Cross-Sectional Studies MH - Adolescent MH - Adult MH - Female MH - Child MH - Young Adult MH - Infant MH - Child, Preschool MH - Middle Aged MH - *Malnutrition/prevention & control/epidemiology MH - *Nutrition Surveys/methods MH - Male MH - Infant, Newborn MH - Pregnancy MH - Research Design PMC - PMC12750752 OTO - NOTNLM OT - Health OT - NUTRITION & DIETETICS OT - PUBLIC HEALTH COIS- Competing interests: None declared. EDAT- 2025/12/31 00:33 MHDA- 2025/12/31 00:34 PMCR- 2025/12/29 CRDT- 2025/12/30 20:43 PHST- 2025/12/31 00:34 [medline] PHST- 2025/12/31 00:33 [pubmed] PHST- 2025/12/30 20:43 [entrez] PHST- 2025/12/29 00:00 [pmc-release] AID - bmjopen-2025-099314 [pii] AID - 10.1136/bmjopen-2025-099314 [doi] PST - epublish SO - BMJ Open. 2025 Dec 29;15(12):e099314. doi: 10.1136/bmjopen-2025-099314. PMID- 41469041 OWN - NLM STAT- MEDLINE DCOM- 20251230 LR - 20260307 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 12 DP - 2025 Dec 29 TI - Cost-effectiveness of pay-for-performance incentives for topical fluoride application among US children: a decision-analytic modelling study. PG - e111302 LID - 10.1136/bmjopen-2025-111302 [doi] LID - e111302 AB - OBJECTIVE: Pay-for-performance (P4P) programmes are increasingly implemented in healthcare to improve quality of care, but their application in dentistry remains limited. Evidence-based approaches are needed to guide incentive design in value-based dental care, particularly for preventive services, such as topical fluoride application in children. We sought to assess the potential cost-effectiveness of P4P incentives for increasing topical fluoride application among children and to illustrate how simulation modelling can identify conditions under which subgroup-specific incentive levels may be optimal. DESIGN, SETTING AND PARTICIPANTS: We developed and validated a decision-analytic microsimulation model using nationally representative data from the National Health and Nutrition Examination Survey (NHANES 2011-2016) to simulate a cohort of 100 000 US children aged 0-19 years over a 10-year period starting in 2024. The model incorporated heterogeneity in demographic and clinical characteristics to estimate changes in dental caries, quality-adjusted life years (QALYs) and healthcare costs under hypothetical P4P programmes that increased topical fluoride coverage by 2.5% to 50% relative to the baseline rate of 24.5%, with incentive amounts ranging from 2.5% to 50% of provider salary. Sensitivity analyses assessed robustness to variation in key parameters. MAIN OUTCOMES: Cumulative incidence of dental caries, QALYs, total healthcare costs and incremental cost-effectiveness ratios (ICERs). RESULTS: Across a broad range of incentive-coverage combinations, P4P incentives were generally cost-effective. For example, a 10% salary-based incentive linked to a 5% relative coverage increase reduced 186.3 cases of tooth decay and yielded 33.8 QALY gains per 10 000 children, resulting in an ICER of $8501 per QALY gained. The intervention was estimated to be cost-saving at coverage increases >/=27.5%. Subgroup analysis indicated larger absolute benefits among racial/ethnic minority children. CONCLUSION: P4P incentives to increase topical fluoride application in children could be cost-effective, and potentially cost-saving, under certain conditions. Cost-effectiveness modelling can help define incentive-coverage combinations that are likely to promote both efficiency and equity. Empirical studies are needed to validate provider responsiveness and establish achievable benchmarks for programme design. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Choi, Sung Eun AU - Choi SE AUID- ORCID: 0000-0002-4001-7638 AD - Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, Massachusetts, USA sung_choi@hsdm.harvard.edu. FAU - Nolte, Daniel AU - Nolte D AD - Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, Massachusetts, USA. FAU - Pandya, Ankur AU - Pandya A AD - Department of Health Policy and Management, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. LA - eng GR - R00 MD016895/MD/NIMHD NIH HHS/United States PT - Journal Article DEP - 20251229 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - 0 (Fluorides, Topical) SB - IM MH - Humans MH - *Cost-Benefit Analysis MH - Child MH - *Fluorides, Topical/economics/administration & dosage/therapeutic use MH - Child, Preschool MH - United States/epidemiology MH - *Reimbursement, Incentive/economics MH - Adolescent MH - Male MH - Infant MH - *Dental Caries/prevention & control/economics/epidemiology MH - Female MH - Quality-Adjusted Life Years MH - Decision Support Techniques MH - Young Adult MH - Infant, Newborn MH - Nutrition Surveys MH - Fluoride Treatment PMC - PMC12750797 OTO - NOTNLM OT - Decision Making OT - Health economics OT - Health policy OT - Quality Improvement COIS- Competing interests: None declared. EDAT- 2025/12/31 00:33 MHDA- 2025/12/31 00:34 PMCR- 2025/12/29 CRDT- 2025/12/30 20:43 PHST- 2025/12/31 00:34 [medline] PHST- 2025/12/31 00:33 [pubmed] PHST- 2025/12/30 20:43 [entrez] PHST- 2025/12/29 00:00 [pmc-release] AID - bmjopen-2025-111302 [pii] AID - 10.1136/bmjopen-2025-111302 [doi] PST - epublish SO - BMJ Open. 2025 Dec 29;15(12):e111302. doi: 10.1136/bmjopen-2025-111302. PMID- 41468232 OWN - NLM STAT- MEDLINE DCOM- 20260318 LR - 20260318 IS - 1543-5474 (Electronic) IS - 1543-3080 (Linking) VI - 23 IP - 4 DP - 2026 Apr 1 TI - A Simple Tool to Assess Outdoor Gym Use. PG - 567-571 LID - 10.1123/jpah.2025-0434 [doi] AB - INTRODUCTION: Outdoor gyms present an opportunity to promote resistance training (RT) among the general population, however, there is a lack of reliable tools that can measure outdoor gym usage. We developed a modified version of the System of Observing Play and Recreation in Communities to assess Resistance Training using outdoor gyms (SOPARC-RT). METHODS: Paired assessors completed observations (N = 24) across 4 outdoor gyms. The interrater reliability was assessed using Bland-Altman plots, intraclass correlation coefficients, and weighted kappa coefficients based on distribution of the data. RESULTS: The SOPARC-RT tool demonstrated excellent interrater reliability for all users overall (intraclass correlation coefficients = .96; 95% confidence interval, .91-.99), as well as youth (children and adolescents), adults and seniors. CONCLUSIONS: SOPARC-RT is a reliable tool that can be utilized by researchers and local government agencies interested in measuring RT using outdoor gym equipment among the general population. FAU - Jansson, Anna K AU - Jansson AK AUID- ORCID: 0000-0001-9039-2033 AD - School of Health Sciences, College of Health, Medicine and Wellbeing, University of Newcastle, Callaghan, NSW, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. FAU - Duncan, Mitch J AU - Duncan MJ AUID- ORCID: 0000-0002-9166-6195 AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. AD - Global Sport and Movement Collaborative, University of Newcastle, Callaghan, NSW, Australia. AD - School of Medicine and Public Health, University of Newcastle, Callaghan,NSW, Australia. FAU - Beacroft, Sam AU - Beacroft S AUID- ORCID: 0009-0005-5821-9800 AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. AD - Global Sport and Movement Collaborative, University of Newcastle, Callaghan, NSW, Australia. FAU - Lubans, David R AU - Lubans DR AUID- ORCID: 0000-0002-0204-8257 AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. AD - Global Sport and Movement Collaborative, University of Newcastle, Callaghan, NSW, Australia. AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. FAU - Attia, John AU - Attia J AUID- ORCID: 0000-0001-9800-1308 AD - School of Medicine and Public Health, University of Newcastle, Callaghan,NSW, Australia. FAU - Bauman, Adrian AU - Bauman A AUID- ORCID: 0000-0002-0369-4621 AD - School of Public Health, The University of Sydney, Camperdown,NSW, Australia. FAU - Smith, Jordan J AU - Smith JJ AUID- ORCID: 0000-0003-4640-8645 AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. AD - Global Sport and Movement Collaborative, University of Newcastle, Callaghan, NSW, Australia. FAU - Plotnikoff, Ronald C AU - Plotnikoff RC AUID- ORCID: 0000-0002-3763-8273 AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. AD - Global Sport and Movement Collaborative, University of Newcastle, Callaghan, NSW, Australia. LA - eng PT - Journal Article DEP - 20251216 PL - United States TA - J Phys Act Health JT - Journal of physical activity & health JID - 101189457 SB - IM MH - Humans MH - Adult MH - Adolescent MH - Reproducibility of Results MH - Child MH - *Resistance Training MH - Male MH - Female MH - Aged MH - Young Adult MH - Middle Aged MH - *Fitness Centers/statistics & numerical data MH - Recreation MH - Observer Variation OTO - NOTNLM OT - measurement OT - resistance training EDAT- 2025/12/30 19:11 MHDA- 2026/03/18 12:53 CRDT- 2025/12/30 12:25 PHST- 2025/06/19 00:00 [received] PHST- 2025/09/23 00:00 [revised] PHST- 2025/10/26 00:00 [accepted] PHST- 2026/03/18 12:53 [medline] PHST- 2025/12/30 19:11 [pubmed] PHST- 2025/12/30 12:25 [entrez] AID - 10.1123/jpah.2025-0434 [doi] PST - epublish SO - J Phys Act Health. 2025 Dec 16;23(4):567-571. doi: 10.1123/jpah.2025-0434. Print 2026 Apr 1. PMID- 41468223 OWN - NLM STAT- MEDLINE DCOM- 20260127 LR - 20260127 IS - 1555-0273 (Electronic) IS - 1555-0265 (Linking) VI - 21 IP - 2 DP - 2026 Feb 1 TI - Feasibility and Accuracy of Body-Fat Assessment Using Standardized Skinfold-Thickness Assessment Versus Dual-Energy X-Ray Absorptiometry in Paralympic Athletes. PG - 241-251 LID - 10.1123/ijspp.2025-0284 [doi] AB - PURPOSE: To evaluate the feasibility and accuracy of body-fat assessment using standardized skinfold-thickness assessment versus dual-energy X-ray absorptiometry (DXA) in Paralympic athletes. METHOD: In this cross-sectional study, body composition was assessed in 49 male and female Paralympic athletes (Para cycling, Para skiing, Para swimming, wheelchair basketball, and wheelchair tennis) by a whole-body DXA scan and skinfold-thickness measurements conducted according to International Society for the Advancement of Kinanthropometry (ISAK) standards. Correlation and Bland-Altman analyses were conducted to compare both methods. RESULTS: DXA was feasible in all athletes, while the sums of 4, 7, and 8 skinfolds were obtained in 88%, 73%, and 73% of the athletes, respectively. Median DXA-derived body-fat percentage was 16.3% (13.4%-20.5%) in males and 27.8% (21.1%-33.4%) in females. Strong correlations were found between DXA-derived body-fat percentage and the sum of 4 (r = .85), 7 (r = .83), and 8 (r = .83) skinfolds. However, skinfold-based prediction equations for estimating body-fat percentage were associated with substantial negative bias (-2.0% to -7.9%) and large individual error compared with DXA. CONCLUSION: DXA is a feasible method for assessing body composition in Paralympic athletes, while ISAK skinfold measurements face some challenges due to disability-related landmarking issues. Despite these limitations, skinfold thickness remains strongly associated with DXA-derived body fat. It is recommended to measure all skinfolds that can be reliably obtained according to ISAK standards and interpret them as a cumulative "sum of feasible sites," rather than enforcing a universal skinfold metric across all Paralympic athletes. FAU - van Schijndel, Nick AU - van Schijndel N AUID- ORCID: 0009-0006-2714-9309 AD - School of Sport and Exercise, HAN University of Applied Sciences, Nijmegen, the Netherlands. FAU - Weijer, Vera AU - Weijer V AUID- ORCID: 0000-0003-0460-4955 AD - School of Sport and Exercise, HAN University of Applied Sciences, Nijmegen, the Netherlands. FAU - van Loon, Luc J C AU - van Loon LJC AUID- ORCID: 0000-0002-6768-9231 AD - Department of Human Biology, NUTRIM, Maastricht University Medical Center+, Maastricht, the Netherlands. FAU - van Dijk, Jan-Willem AU - van Dijk JW AUID- ORCID: 0000-0001-9674-1505 AD - School of Sport and Exercise, HAN University of Applied Sciences, Nijmegen, the Netherlands. LA - eng PT - Comparative Study PT - Journal Article DEP - 20251215 PL - United States TA - Int J Sports Physiol Perform JT - International journal of sports physiology and performance JID - 101276430 SB - IM MH - Humans MH - *Absorptiometry, Photon MH - Male MH - Female MH - *Skinfold Thickness MH - Cross-Sectional Studies MH - Feasibility Studies MH - Young Adult MH - Adult MH - *Para-Athletes MH - *Sports for Persons with Disabilities MH - Body Composition MH - *Adipose Tissue/diagnostic imaging MH - Athletes MH - Adolescent OTO - NOTNLM OT - DXA OT - anthropometry OT - body composition OT - disabled athletes EDAT- 2025/12/30 19:11 MHDA- 2026/01/27 12:58 CRDT- 2025/12/30 12:24 PHST- 2025/06/19 00:00 [received] PHST- 2025/10/28 00:00 [revised] PHST- 2025/10/28 00:00 [accepted] PHST- 2026/01/27 12:58 [medline] PHST- 2025/12/30 19:11 [pubmed] PHST- 2025/12/30 12:24 [entrez] AID - 10.1123/ijspp.2025-0284 [doi] PST - epublish SO - Int J Sports Physiol Perform. 2025 Dec 15;21(2):241-251. doi: 10.1123/ijspp.2025-0284. Print 2026 Feb 1. PMID- 41468068 OWN - NLM STAT- MEDLINE DCOM- 20260417 LR - 20261019 IS - 1556-8342 (Electronic) IS - 1556-8253 (Linking) VI - 21 IP - 4 DP - 2026 Apr TI - Comparison of the Effects of Breast Milk and Hamamelis virginiana (Witch Hazel) on the Healing of Diaper Dermatitis in Infants: A Randomized Trial. PG - 258-264 LID - 10.1177/15568253251406258 [doi] AB - BACKGROUND: Diaper dermatitis (DD) is a very common problem in infants between 1 and 6 months. While it rarely causes long-lasting problems, it can cause serious short-term problems for both infants and parents. Accordingly, this study compared the effect of breast milk and diaper rash cream containing Hamamelis virginiana (12 mg/100 g) on the healing process in 0-6 month-old infants with DD. METHODS: This randomized, single-blinded trial was conducted with 60 infants aged 0-6 months diagnosed with DD. Participants were assigned to either the breast milk group (BG) or the comparison group (CG) receiving Hamamelis virginiana cream. Demographic characteristics and DD severity were assessed using a structured demographic questionnaire and the validated Assessment of the Severity of Uncomplicated DD in Infants Scale. Statistical analyses included Shapiro-Wilk, Mann-Whitney U, Wilcoxon signed rank, Chi-square, and Fisher's exact tests. Significance was set at p < 0.05. RESULTS: Before the intervention, the mean scale score was 5.17 +/- 0.46 in the BG, 2.83 +/- 1.37 in the CG, which was a statistically significant difference. After the intervention, there was a significant decrease in the mean scale score in the BG to 0.03 +/- 0.18, whereas the mean decrease was smaller in the CG (1.53 +/- 1.11). The difference in the mean scale scores between the groups was statistically significant (p < 0.001). Furthermore, the postintervention mean scale score of the BG was significantly lower than that of the CG. However, baseline severity differences limit direct comparison of treatment efficacy. CONCLUSIONS: Topically applied breast milk appears to be a safe, accessible, and cost-effective option for treating uncomplicated DD, with greater improvement than cream containing Hamamelis virginiana. However, baseline severity differences limit direct comparison. Further studies using block randomization are recommended. FAU - Sevimli Guler, Dondu AU - Sevimli Guler D AD - Department of Nursing, Faculty of Health Sciences, Sakarya University of Applied Sciences, Sakarya, Turkiye. FAU - Vural, Gulsen AU - Vural G AD - Department of Nursing, Faculty of Health Sciences, Atilim University, Ankara, Turkiye. FAU - Turan, Zekiye AU - Turan Z AD - Department of Nursing, Faculty of Health Sciences, Sakarya University, Sakarya, Turkiye. FAU - Unal Toprak, Filiz AU - Unal Toprak F AD - Department of Midwifery, Gulhane Faculty of Health Sciences, University of Health Sciences, Ankara, Turkiye. FAU - Melek Arsoy, Hacer Efnan AU - Melek Arsoy HE AD - Department of Internal Medical Sciences, Faculty of Medicine, Sakarya University, Sakarya, Turkiye. AD - Department of Child Health and Diseases, Faculty of Medicine, Sakarya University, Sakarya, Turkiye. LA - eng PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20251222 PL - United States TA - Breastfeed Med JT - Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine JID - 101260777 SB - IM MH - Humans MH - *Diaper Rash/drug therapy MH - Infant MH - Female MH - *Milk, Human MH - Infant, Newborn MH - Male MH - Single-Blind Method MH - Breast Feeding MH - Treatment Outcome MH - Skin Cream/administration & dosage OTO - NOTNLM OT - Hamamelis virginiana OT - breastmilk OT - diaper dermatitis OT - infant OT - randomized controlled trial EDAT- 2025/12/30 13:08 MHDA- 2026/04/19 17:41 CRDT- 2025/12/30 11:43 PHST- 2026/04/19 17:41 [medline] PHST- 2025/12/30 13:08 [pubmed] PHST- 2025/12/30 11:43 [entrez] AID - 10.1177/15568253251406258 [doi] PST - ppublish SO - Breastfeed Med. 2026 Apr;21(4):258-264. doi: 10.1177/15568253251406258. Epub 2025 Dec 22. PMID- 41467600 OWN - NLM STAT- MEDLINE DCOM- 20260316 LR - 20260813 IS - 1308-5735 (Electronic) IS - 1308-5727 (Print) VI - 18 IP - 1 DP - 2026 Mar 13 TI - Diagnostic Value of Peak-to-Basal Difference or Ratio of Growth Hormone in Children with Growth Hormone Deficiency. PG - 138-144 LID - 10.4274/jcrpe.galenos.2025.2025-10-26 [doi] AB - OBJECTIVE: Growth hormone (GH) deficiency (GHD) is a rare but important cause of short stature in children. Although GH stimulation tests remain the gold standard for diagnosis, establishing a definitive diagnosis continues to be challenging. Our aim was to evaluate the diagnostic performance of the peak-to-basal ratio and difference for identifying GHD in children. METHODS: Patients with short stature who were evaluated for GHD with GH stimulation tests were retrospectively assessed. DeltaGH was defined as the difference between peak and basal GH levels. The GH ratio was calculated as the ratio of peak to basal GH levels. RESULTS: Data were collected from 265 patients (182 prepubertal) with a median age at presentation of 10.6 years (interquartile range: 6.13-12.42), of whom 46.7% were female. In total, 146 patients met the diagnostic criteria for GHD. DeltaGH and GH ratio during the L-Dopa and Clonidine stimulation tests were significantly lower in the GHD group (p<0.001). A DeltaGH cut-off of 0.05). The treatment effects did not significantly differ by sex. PL-based ECE interventions may enhance stability skills in motor development, but further research in larger samples is needed to determine broader impacts on early childhood development. FAU - Wilhite, Breanne C AU - Wilhite BC AUID- ORCID: 0009-0002-5281-6776 AD - Division of Nutrition Interventions, Communications and Behavior Change, Tufts University Friedman School of Nutrition Science and Policy, Boston, MA 02111, USA. FAU - Chui, Kenneth AU - Chui K AUID- ORCID: 0000-0002-8063-8631 AD - Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA 02111, USA. FAU - Sacheck, Jennifer M AU - Sacheck JM AUID- ORCID: 0000-0002-7690-663X AD - Department of Social and Behavioral Sciences, Brown University School of Public Health, Providence, RI 02903, USA. FAU - Hatfield, Daniel P AU - Hatfield DP AD - Division of Nutrition Interventions, Communications and Behavior Change, Tufts University Friedman School of Nutrition Science and Policy, Boston, MA 02111, USA. AD - FHI 360, Washington, DC 20037, USA. FAU - Morris, Margaret AU - Morris M AD - Tufts University School of Occupational Therapy, Medford, MA 02155, USA. FAU - Ziembowicz, Megan AU - Ziembowicz M AD - Tufts University School of Occupational Therapy, Medford, MA 02155, USA. FAU - Herrick, Stephanie AU - Herrick S AD - Rising New York Road Runners, New York Road Runners, New York City, NY 10019, USA. FAU - Hennessy, Erin AU - Hennessy E AD - Division of Nutrition Interventions, Communications and Behavior Change, Tufts University Friedman School of Nutrition Science and Policy, Boston, MA 02111, USA. LA - eng GR - R21 CA226829/CA/NCI NIH HHS/United States GR - 2017/Caplan Foundation for Early Childhood/ PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PT - Research Support, U.S. Gov't, Non-P.H.S. DEP - 20251213 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Humans MH - Child, Preschool MH - Male MH - Female MH - *Motor Skills MH - *Self-Control MH - *Exercise MH - Massachusetts MH - Child Development MH - *Early Intervention, Educational MH - *Literacy PMC - PMC12732799 OTO - NOTNLM OT - childcare OT - early childhood development OT - fundamental movement skills OT - gross motor competence OT - physical literacy OT - self-regulation COIS- The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results. Author DH was employed by the non-profit organization FHI360. The non-profit organization had no role in the design of the study; in the collection, analysis, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. Author SH was employed by the non-profit organization New York Road Runners. The non-profit organization had no role in the design of the study; in the collection, analysis, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results. EDAT- 2025/12/30 07:41 MHDA- 2025/12/30 07:42 PMCR- 2025/12/13 CRDT- 2025/12/30 01:59 PHST- 2025/07/01 00:00 [received] PHST- 2025/11/28 00:00 [revised] PHST- 2025/12/01 00:00 [accepted] PHST- 2025/12/30 07:42 [medline] PHST- 2025/12/30 07:41 [pubmed] PHST- 2025/12/30 01:59 [entrez] PHST- 2025/12/13 00:00 [pmc-release] AID - ijerph22121861 [pii] AID - ijerph-22-01861 [pii] AID - 10.3390/ijerph22121861 [doi] PST - epublish SO - Int J Environ Res Public Health. 2025 Dec 13;22(12):1861. doi: 10.3390/ijerph22121861. PMID- 41464424 OWN - NLM STAT- MEDLINE DCOM- 20251230 LR - 20260824 IS - 1660-4601 (Electronic) IS - 1661-7827 (Print) IS - 1660-4601 (Linking) VI - 22 IP - 12 DP - 2025 Nov 26 TI - The Influence of Parental Behaviours and Socioeconomic Factors on Offspring's Precursors of Atherosclerosis: A Systematic Review and Meta-Analysis of Observational Studies. LID - 10.3390/ijerph22121791 [doi] LID - 1791 AB - Parents can influence both the behaviours and cardiovascular health of their school-aged children and adolescents. Understanding these effects is essential for developing targeted interventions. This systematic review and meta-analysis aims to report existing research findings on the associations between parental lifestyle behaviours, socioeconomic status (SES), and educational level (EDL) and offspring's arterial stiffness (AS) and blood pressure (BP). Following PRISMA methodology, 19 observational studies were selected from the PubMed, Scopus, and EBSCO databases. Inclusion criteria focused on age range, children's AS and BP, parental behaviours, SES, and EDL. The STROBE checklist ensured the quality and reliability of the included studies. The meta-analysis included data from three or more studies. Higher levels of maternal physical activity were associated with lower AS in offspring. Parental smoking was associated with increased AS and higher BP in offspring. The meta-analyses showed that a lower EDL was associated with higher AS in offspring, 0.22 (95% CI: 0.15, 0.29; p < 0.001). No significant associations were found between parental SES and offspring's systolic (p = 0.40) and diastolic (p = 0.50) BP. Parental behaviours shape offspring's cardiovascular health. Parental physical activity and higher EDL seem to be protective, while parental smoking is associated with adverse outcomes. Further research is needed to clarify these relationships. FAU - Silva, Ana Carvalhinho AU - Silva AC AUID- ORCID: 0000-0002-1054-0831 AD - Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), University of Maia (UMaia), 4475-690 Maia, Portugal. FAU - Maia, Filipe AU - Maia F AUID- ORCID: 0000-0002-4026-3804 AD - Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), University of Maia (UMaia), 4475-690 Maia, Portugal. FAU - Estima, Francisco AU - Estima F AUID- ORCID: 0009-0007-5052-9710 AD - Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), University of Maia (UMaia), 4475-690 Maia, Portugal. FAU - Gaya, Anelise AU - Gaya A AUID- ORCID: 0000-0002-8335-6947 AD - Graduate Program in Human Movement Sciences, Federal University of Rio Grande do Sul (PPGCMH-UFRGS), Porto Alegre 90690-200, RS, Brazil. AD - School of Physical Education and Physiotherapy, Federal University of Pelotas (ESEF-UFPEL), Pelotas 96055-630, RS, Brazil. FAU - Christofaro, Diego AU - Christofaro D AUID- ORCID: 0000-0001-9917-9992 AD - Graduate Program in Movement Sciences, Department of Physical Education, School of Technology and Sciences, Sao Paulo State University (PPGCM-FCT-UNESP), Presidente Prudente 19060-900, SP, Brazil. FAU - Mota, Jorge AU - Mota J AUID- ORCID: 0000-0001-7571-9181 AD - Research Centre in Physical Activity, Health, and Leisure (CIAFEL), Faculty of Sport, University of Porto (FADE-UP), 4050-313 Porto, Portugal. AD - Laboratory for Integrative and Translational Research in Population Health (ITR), 4050-091 Porto, Portugal. FAU - Aires, Luisa AU - Aires L AUID- ORCID: 0000-0001-9717-4186 AD - Research Centre in Physical Activity, Health, and Leisure (CIAFEL), Faculty of Sport, University of Porto (FADE-UP), 4050-313 Porto, Portugal. AD - Laboratory for Integrative and Translational Research in Population Health (ITR), 4050-091 Porto, Portugal. FAU - Silva, Gustavo AU - Silva G AUID- ORCID: 0000-0003-3930-7037 AD - Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), University of Maia (UMaia), 4475-690 Maia, Portugal. LA - eng GR - UID/04045/Portuguese Foundation for Science and Technology (FCT)/ GR - 2022.14139.BD/Portuguese Foundation for Science and Technology (FCT)/ PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20251126 PL - Switzerland TA - Int J Environ Res Public Health JT - International journal of environmental research and public health JID - 101238455 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - *Atherosclerosis/epidemiology/etiology MH - Blood Pressure MH - Exercise MH - Life Style MH - Observational Studies as Topic MH - *Parents MH - Socioeconomic Factors MH - Vascular Stiffness PMC - PMC12732730 OTO - NOTNLM OT - adolescents OT - arterial stiffness OT - blood pressure OT - children OT - educational level OT - parents OT - socioeconomic status COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:41 MHDA- 2025/12/30 07:42 PMCR- 2025/11/26 CRDT- 2025/12/30 01:58 PHST- 2025/08/21 00:00 [received] PHST- 2025/11/12 00:00 [revised] PHST- 2025/11/19 00:00 [accepted] PHST- 2025/12/30 07:42 [medline] PHST- 2025/12/30 07:41 [pubmed] PHST- 2025/12/30 01:58 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - ijerph22121791 [pii] AID - ijerph-22-01791 [pii] AID - 10.3390/ijerph22121791 [doi] PST - epublish SO - Int J Environ Res Public Health. 2025 Nov 26;22(12):1791. doi: 10.3390/ijerph22121791. PMID- 41464369 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260102 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 24 DP - 2025 Dec 16 TI - Artificial Intelligence in Sub-Elite Youth Football Players: Predicting Recovery Through Machine Learning Integration of Physical, Technical, Tactical and Maturational Data. LID - 10.3390/healthcare13243301 [doi] LID - 3301 AB - Background: Monitoring training load and recovery is essential for performance optimization and injury prevention in youth football. However, predicting subjective recovery in preadolescent athletes remains challenging due to biological variability and the multidimensional nature of training responses. This exploratory study examined whether supervised machine learning (ML) models could predict Total Quality of Recovery (TQR) using integrated external load, internal load, anthropometric and maturational variables collected over one competitive microcycle. Methods: Forty male sub-elite U11 and U13 football players (age 10.3 +/- 0.7 years; height 1.43 +/- 0.08 m; body mass 38.6 +/- 6.2 kg; BMI 18.7 +/- 2.1 kg/m(2)) completed a microcycle comprising four training sessions (MD-4 to MD-1) and one official match (MD). A total of 158 performance-related variables were extracted, including external load (GPS-derived metrics), internal load (RPE and sRPE), heart rate indicators (U13 only), anthropometric and maturational measures, and tactical-cognitive indices (FUT-SAT). After preprocessing and aggregation at the player level, five supervised ML algorithms-K-Nearest Neighbors (KNN), Support Vector Machine (SVM), Decision Tree (DT), Random Forest (RF), and Gradient Boosting (GB)-were trained using a 70/30 train-test split and 5-fold cross-validation to classify TQR into Low, Moderate, and High categories. Results: Tree-based models (DT, GB) demonstrated the highest predictive performance, whereas linear and distance-based approaches (SVM, KNN) showed lower discriminative ability. Anthropometric and maturational factors emerged as the most influential predictors of TQR, with external and internal load contributing modestly. Predictive accuracy was moderate, reflecting the developmental variability characteristics of this age group. Conclusions: Using combined physiological, mechanical, and maturational data, these ML-based monitoring systems can simulate subjective recovery in young football players, offering potential as decision-support tools in youth sub-elite football and encouraging a more holistic and individualized approach to training and recovery management. FAU - Afonso, Pedro AU - Afonso P AUID- ORCID: 0009-0000-1077-7233 AD - Biosciences Higher School of Elvas, Polytechnic Institute of Portalegre, 7300-110 Portalegre, Portugal. AD - Department of Sport, Exercise and Health Sciences, University of Tras-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal. AD - Research Centre for Active Living and Wellbeing (Livewell), Instituto Politecnico de Braganca, 5300-253 Braganca, Portugal. AD - Department of Sports, Higher Institute of Educational Sciences of the Douro, 4560-708 Penafiel, Portugal. FAU - Forte, Pedro AU - Forte P AUID- ORCID: 0000-0003-0184-6780 AD - Research Centre for Active Living and Wellbeing (Livewell), Instituto Politecnico de Braganca, 5300-253 Braganca, Portugal. AD - CI-ISCE, ISCE Douro, 4560-547 Penafiel, Portugal. AD - Department of Sports Sciences, Instituto Politecnico de Braganca, 5300-252 Braganca, Portugal. FAU - Branquinho, Luis AU - Branquinho L AUID- ORCID: 0000-0001-9000-5419 AD - Biosciences Higher School of Elvas, Polytechnic Institute of Portalegre, 7300-110 Portalegre, Portugal. AD - Life Quality Research Center (LQRC-CIEQV), 2001-964 Santarem, Portugal. FAU - Ferraz, Ricardo AU - Ferraz R AUID- ORCID: 0000-0002-7530-512X AD - Department of Sport Sciences, University of Beira Interior, 6201-001 Covilha, Portugal. AD - Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), 5000-801 Vila Real, Portugal. FAU - Garrido, Nuno Domingues AU - Garrido ND AUID- ORCID: 0000-0002-8105-7580 AD - Department of Sport, Exercise and Health Sciences, University of Tras-os-Montes e Alto Douro, 5000-801 Vila Real, Portugal. AD - Research Center in Sports Sciences, Health Sciences and Human Development (CIDESD), 5000-801 Vila Real, Portugal. FAU - Teixeira, Jose Eduardo AU - Teixeira JE AUID- ORCID: 0000-0003-4612-3623 AD - Department of Sports Sciences, Polytechnic Institute of Guarda, 6300-559 Guarda, Portugal. AD - Department of Sports Sciences, Polytechnic of Cavado and Ave, 4750-810 Guimaraes, Portugal. AD - SPRINT-Sport Physical Activity and Health Research & Innovation Center, 6300-559 Guarda, Portugal. LA - eng GR - project UID/CED/04748/2020, UIDB04045/2021 and UID/6157/2025/FCT - Fundacao para a Ciencia e a Tecnologia, I.P.,/ PT - Journal Article DEP - 20251216 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12732887 OTO - NOTNLM OT - machine learning OT - maturation OT - performance OT - recovery OT - youth soccer COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:41 MHDA- 2025/12/30 07:42 PMCR- 2025/12/16 CRDT- 2025/12/30 01:58 PHST- 2025/11/10 00:00 [received] PHST- 2025/12/09 00:00 [revised] PHST- 2025/12/10 00:00 [accepted] PHST- 2025/12/30 07:42 [medline] PHST- 2025/12/30 07:41 [pubmed] PHST- 2025/12/30 01:58 [entrez] PHST- 2025/12/16 00:00 [pmc-release] AID - healthcare13243301 [pii] AID - healthcare-13-03301 [pii] AID - 10.3390/healthcare13243301 [doi] PST - epublish SO - Healthcare (Basel). 2025 Dec 16;13(24):3301. doi: 10.3390/healthcare13243301. PMID- 41464353 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260919 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 24 DP - 2025 Dec 15 TI - Exploring Breastfeeding Practices and Obstacles Among Mothers With and Without Congenital Heart Disease. LID - 10.3390/healthcare13243284 [doi] LID - 3284 AB - Background: Breastfeeding provides optimal nutrition and immunological protection, offering critical benefits for infants with congenital heart disease (CHD) and their mothers. This study aims to determine the prevalence of breastfeeding practices and identify common obstacles among mothers with and without CHD whose children are diagnosed with CHD. Methods: This cross-sectional study assessed breastfeeding prevalence and obstacles among mothers with and without congenital heart disease (CHD) whose children were also diagnosed with CHD. Data were collected from January to August 2025 across tertiary hospitals and pediatric cardiology units in Saudi Arabia. A validated bilingual questionnaire (Cronbach's alpha = 0.816) captured maternal, infant, and breastfeeding-related factors. Descriptive statistics, chi-square tests, and odds ratios were applied, with significance set at p < 0.05. Results: A total of 419 mothers of children with congenital heart disease (CHD) participated. Maternal CHD was reported in 15.8% of participants and was significantly associated with older maternal age, family history of CHD, low birth weight, and the presence of other chronic diseases (p < 0.05). Ventricular septal defect (VSD) and mitral stenosis were more frequent among children of CHD mothers. Breastfeeding initiation ( approximately 91%) and duration did not differ significantly between CHD and non-CHD mothers. Interestingly, CHD mothers reported fewer breastfeeding obstacles (27.3% vs. 43.1%, p = 0.04) and were less likely to cite fatigue or pain as reasons for discontinuation. Conclusions: This study provides novel insights into breastfeeding practices and maternal child health characteristics among mothers and infants affected by CHD in Saudi Arabia. The current study findings revealed that maternal CHD was significantly associated with advanced maternal age, family history, low birth weight, and coexisting chronic conditions, highlighting important genetic and perinatal risk factors. Despite these health burdens, breastfeeding initiation and duration did not significantly differ between CHD and non-CHD mothers, suggesting that maternal CHD alone does not hinder breastfeeding success. FAU - Alrashed, Fahad Abdulaziz AU - Alrashed FA AUID- ORCID: 0000-0001-5975-3275 AD - Department of Medical Education, College of Medicine, King Saud University, P.O. Box 2925, Riyadh 11472, Saudi Arabia. FAU - AlAngari, Saad M AU - AlAngari SM AD - College of Medicine, King Saud University, Riyadh 11472, Saudi Arabia. FAU - Awartani, Abdullah AU - Awartani A AD - College of Medicine, King Saud University, Riyadh 11472, Saudi Arabia. FAU - Alshalan, Saud AU - Alshalan S AUID- ORCID: 0009-0009-6376-6242 AD - College of Medicine, King Saud University, Riyadh 11472, Saudi Arabia. FAU - Alabdullah, Sultan AU - Alabdullah S AD - College of Medicine, King Saud University, Riyadh 11472, Saudi Arabia. FAU - Subait, Faisal AU - Subait F AUID- ORCID: 0009-0008-3775-5059 AD - College of Medicine, King Saud University, Riyadh 11472, Saudi Arabia. FAU - Alkhateeb, Majd AU - Alkhateeb M AD - College of Medicine, King Saud University, Riyadh 11472, Saudi Arabia. FAU - Mazi, Sarah Ismail AU - Mazi SI AUID- ORCID: 0000-0002-6723-8756 AD - Department of Cardiac Sciences, College of Medicine, King Saud University, P.O. Box 7805, Riyadh 11472, Saudi Arabia. FAU - Alsabih, Ahmed Othman AU - Alsabih AO AUID- ORCID: 0009-0005-9436-6760 AD - Department of Physiology, College of Medicine, King Saud University, Riyadh 11461, Saudi Arabia. FAU - Iqbal, Zafar AU - Iqbal Z AUID- ORCID: 0009-0002-4863-4144 AD - Department of General Surgery, College of Medicine, King Saud University, P.O. Box 7805, Riyadh 11472, Saudi Arabia. FAU - Ahmad, Tauseef AU - Ahmad T AD - Department of Medical Education, College of Medicine, King Saud University, P.O. Box 2925, Riyadh 11472, Saudi Arabia. LA - eng GR - Ongoing research funding program, (ORF-2025-821)/King Saud University, Riyadh, Saudi Arabia/ PT - Journal Article DEP - 20251215 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12732944 OTO - NOTNLM OT - breastfeeding obstacles OT - breastfeeding practices OT - child CHD OT - congenital heart disease OT - health-care education OT - medical education OT - mothers with CHD COIS- No competing interests exist between the authors. EDAT- 2025/12/30 07:41 MHDA- 2025/12/30 07:42 PMCR- 2025/12/15 CRDT- 2025/12/30 01:58 PHST- 2025/10/30 00:00 [received] PHST- 2025/12/03 00:00 [revised] PHST- 2025/12/10 00:00 [accepted] PHST- 2025/12/30 07:42 [medline] PHST- 2025/12/30 07:41 [pubmed] PHST- 2025/12/30 01:58 [entrez] PHST- 2025/12/15 00:00 [pmc-release] AID - healthcare13243284 [pii] AID - healthcare-13-03284 [pii] AID - 10.3390/healthcare13243284 [doi] PST - epublish SO - Healthcare (Basel). 2025 Dec 15;13(24):3284. doi: 10.3390/healthcare13243284. PMID- 41464320 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260919 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 24 DP - 2025 Dec 11 TI - Feasibility and Preliminary Response of a Novel Training Program on Mobility Parameters in Adolescents with Movement Disorders. LID - 10.3390/healthcare13243251 [doi] LID - 3251 AB - Background: There is a critical need for feasible, non-equipment based, safe, and cost-effective exercise interventions to promote muscle strength, dynamic postural balance, and independent mobility in adolescents with cerebral palsy (CP) or spina bifida (SB). Objectives: This study aimed to examine the feasibility and preliminary response of a novel exercise program: Functionally Loaded High-Intensity Circuit Training (FUNHIT) and conventional High-Intensity Circuit Training (HIT) in adolescents with CP/SB. Methods: Enrolled participants were allocated to FUNHIT or HIT or Controls in our randomized control trial. The interventions were delivered 2x/week x 4 weeks. Feasibility was assessed through process, operational, and scientific metrics. Outcome measures included maximum walking speed, Four Square Step Test (FSST), Timed Up and Go (TUG) and its dual-task variants, Lateral Step-Up Test (LSUT), Fear of Falling (FoF) and physical activity (PA) questionnaires. Results: We tested 5 participants (1 CP, 4 SB) in our study. Recruitment and retention rates were acceptable (63% enrollment, 100% retention and adherence). FUNHIT (n = 2) participants showed improvements in maximum walking speed (8-12%), FSST (15-29%), LSUT (22-33%), and TUG (4%). The HIT participant (n = 1) demonstrated improved TUG dual-task performance (40%) and FSST (30%) only. Control participants (n = 2) had varied changes (from 0-24%) in mobility, strength, balance. No adverse events were reported. Participants successfully followed (100%) the prescribed exercise dosage over the four-week period. Conclusions: FUNHIT and HIT are feasible and safe interventions for adolescents with ambulatory CP and SB who retain motor function, showing promising preliminary improvements in muscle strength, dynamic balance, and independent mobility. Our findings need to be validated in larger samples. FAU - Quach, Phuong T M AU - Quach PTM AD - Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35294, USA. FAU - Fisher, Gordon AU - Fisher G AUID- ORCID: 0000-0002-9191-3774 AD - Department of Human Studies, University of Alabama at Birmingham, Birmingham, AL 35294, USA. FAU - Lai, Byron AU - Lai B AD - Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USA. FAU - Modlesky, Christopher M AU - Modlesky CM AD - Department of Kinesiology, University of Georgia, Athens, GA 30602, USA FAU - Hurt, Christopher P AU - Hurt CP AUID- ORCID: 0000-0001-8861-9876 AD - Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35294, USA. FAU - Bowersock, Collin D AU - Bowersock CD AD - Human Performance and Nutrition Research Institute, Oklahoma State University, Stillwater, OK 74077, USA. FAU - Boolani, Ali AU - Boolani A AUID- ORCID: 0000-0002-2261-4498 AD - Human Performance and Nutrition Research Institute, Oklahoma State University, Stillwater, OK 74077, USA. FAU - Singh, Harshvardhan AU - Singh H AUID- ORCID: 0000-0001-5945-8102 AD - Department of Physical Therapy, University of Alabama at Birmingham, Birmingham, AL 35294, USA. AD - Human Performance and Nutrition Research Institute, Oklahoma State University, Stillwater, OK 74077, USA. LA - eng GR - C-PROGRESS/National Pediatric Rehabilitation Resource Center, USA/ PT - Journal Article DEP - 20251211 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12732486 OTO - NOTNLM OT - balance OT - cerebral palsy OT - exercise OT - intervention OT - neuromotor disorder OT - spina bifida COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:41 MHDA- 2025/12/30 07:42 PMCR- 2025/12/11 CRDT- 2025/12/30 01:57 PHST- 2025/08/24 00:00 [received] PHST- 2025/11/26 00:00 [revised] PHST- 2025/12/07 00:00 [accepted] PHST- 2025/12/30 07:42 [medline] PHST- 2025/12/30 07:41 [pubmed] PHST- 2025/12/30 01:57 [entrez] PHST- 2025/12/11 00:00 [pmc-release] AID - healthcare13243251 [pii] AID - healthcare-13-03251 [pii] AID - 10.3390/healthcare13243251 [doi] PST - epublish SO - Healthcare (Basel). 2025 Dec 11;13(24):3251. doi: 10.3390/healthcare13243251. PMID- 41464255 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260102 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 13 IP - 24 DP - 2025 Dec 5 TI - Family-Based Tag Rugby: Acute Effects on Risk Factors for Cardiometabolic Disease and Cognition and Factors Affecting Family Enjoyment and Feasibility. LID - 10.3390/healthcare13243186 [doi] LID - 3186 AB - Background/Objectives: Physical inactivity is associated with increased cardiometabolic disease risk and poor cognition in children and their parents. Family-based physical activity offers an opportunity for children and their parents to engage in physical activity concurrently. The present study examined the effect of an acute bout of family-based tag rugby on risk factors for cardiometabolic disease and cognition in families. Additionally, this study qualitatively explored families' perceptions of enjoyment and factors affecting implementation with considerations for socioeconomic status. Methods: Sixteen families (27 children, 20 parents) participated in an exercise (45 min family-based tag rugby) and resting control trial (45 min seated rest), separated by seven days. Postprandial gylcaemia, insulinaemia, lipaemia and cognitive function were measured following exercise/rest. Families also participated in whole-family focus groups and separate parent and child interviews. Results: In parents, postprandial plasma insulin concentrations were lower on the exercise trial than the rested control trial at 30 min (p = 0.004) and 120 min following the consumption of a standardised lunch (p = 0.011). In children, a significant trial*time interaction for inverse efficiency scores on the Sternberg paradigm (three-item) was exhibited (p = 0.016). In parents, a significant trial*time interaction for inverse efficiency score on the Stroop congruent test was exhibited (trial*time interaction; p = 0.012), whereby inverse efficiency scores improved immediately post-exercise, compared with the rested control trial (p = 0.016). Qualitatively, families from all socioeconomic backgrounds agreed that tag rugby is an inclusive, enjoyable mode of physical activity that families want to participate in together, which can be adapted to overcome the barriers associated with the cost of and access to local facilities. Conclusions: An acute bout of tag rugby improved postprandial insulin concentrations in parents and cognitive function in children and their parents. Tag rugby was deemed an appropriate exercise modality for families from a range of socioeconomic backgrounds. FAU - Fountain, Scarlett M AU - Fountain SM AUID- ORCID: 0009-0000-1918-838X AD - Sport Health and Performance Enhancement (SHAPE) Research Centre, Department of Sport Science, School of Science & Technology, Nottingham Trent University, Nottingham NG11 8NS, UK. FAU - Walters, Grace W M AU - Walters GWM AUID- ORCID: 0009-0009-9532-6014 AD - Sport Health and Performance Enhancement (SHAPE) Research Centre, Department of Sport Science, School of Science & Technology, Nottingham Trent University, Nottingham NG11 8NS, UK. FAU - Williams, Ryan A AU - Williams RA AUID- ORCID: 0000-0002-1346-7756 AD - Sport Health and Performance Enhancement (SHAPE) Research Centre, Department of Sport Science, School of Science & Technology, Nottingham Trent University, Nottingham NG11 8NS, UK. FAU - Sunderland, Caroline AU - Sunderland C AUID- ORCID: 0000-0001-7484-1345 AD - Sport Health and Performance Enhancement (SHAPE) Research Centre, Department of Sport Science, School of Science & Technology, Nottingham Trent University, Nottingham NG11 8NS, UK. FAU - Cooper, Simon B AU - Cooper SB AUID- ORCID: 0000-0001-5219-5020 AD - Sport Health and Performance Enhancement (SHAPE) Research Centre, Department of Sport Science, School of Science & Technology, Nottingham Trent University, Nottingham NG11 8NS, UK. FAU - Dring, Karah J AU - Dring KJ AUID- ORCID: 0000-0002-9647-3579 AD - Sport Health and Performance Enhancement (SHAPE) Research Centre, Department of Sport Science, School of Science & Technology, Nottingham Trent University, Nottingham NG11 8NS, UK. LA - eng PT - Journal Article DEP - 20251205 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC12733199 OTO - NOTNLM OT - cardiometabolic health OT - cognitive function OT - family-based physical activity OT - socioeconomic status COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:41 MHDA- 2025/12/30 07:42 PMCR- 2025/12/05 CRDT- 2025/12/30 01:57 PHST- 2025/10/31 00:00 [received] PHST- 2025/12/01 00:00 [revised] PHST- 2025/12/03 00:00 [accepted] PHST- 2025/12/30 07:42 [medline] PHST- 2025/12/30 07:41 [pubmed] PHST- 2025/12/30 01:57 [entrez] PHST- 2025/12/05 00:00 [pmc-release] AID - healthcare13243186 [pii] AID - healthcare-13-03186 [pii] AID - 10.3390/healthcare13243186 [doi] PST - epublish SO - Healthcare (Basel). 2025 Dec 5;13(24):3186. doi: 10.3390/healthcare13243186. PMID- 41464237 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260102 IS - 2075-4418 (Print) IS - 2075-4418 (Electronic) IS - 2075-4418 (Linking) VI - 15 IP - 24 DP - 2025 Dec 18 TI - Integrated Anthropometric, Physiological and Biological Assessment of Elite Youth Football Players Using Machine Learning. LID - 10.3390/diagnostics15243238 [doi] LID - 3238 AB - Background: Youth football players experience rapid physical and biological changes while being exposed to high training loads, increasing performance demands and musculoskeletal injury risk. Current evaluations often analyze anthropometric, physiological, and biological domains separately, and few studies integrate these dimensions using machine-learning (ML) approaches. Objective: To provide a multidimensional assessment of elite youth football players and investigate how anthropometric, physical, and biological markers jointly relate to performance through classical statistics and ML. Methods: One hundred elite players (14-18 years) underwent standardized anthropometric, physical, and laboratory assessments. Analyses included descriptive statistics, ANOVA/MANOVA, PCA, factor analysis, composite biological indices, and ML models (linear regression, SVR) with 5-fold cross-validation. K-means clustering explored hidden adaptation phenotypes. Results: Older players showed higher weight and BMI, physical testing revealed consistent limb asymmetry (~5%), and biological markers remained within reference ranges. PCA and factor analysis extracted latent structural and metabolic domains. Linear regression predicted performance with R(2) approximately 0.59, while SVR underperformed. K-means identified three adaptation phenotypes. Conclusions: Performance and resilience arise from interactions between structural, functional, and biological domains. Interpretable ML methods enhance individualized monitoring, early risk detection, and evidence-based injury-prevention strategies. FAU - Nechita, Luiza Camelia AU - Nechita LC AD - Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University of Galati, 800008 Galati, Romania. FAU - Gurau, Tudor Vladimir AU - Gurau TV AD - Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University of Galati, 800008 Galati, Romania. FAU - Musat, Carmina Liana AU - Musat CL AUID- ORCID: 0000-0002-2383-6455 AD - Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University of Galati, 800008 Galati, Romania. FAU - Tupu, Ancuta Elena AU - Tupu AE AUID- ORCID: 0009-0006-3855-2056 AD - Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University of Galati, 800008 Galati, Romania. FAU - Gurau, Gabriela AU - Gurau G AUID- ORCID: 0000-0001-8327-1364 AD - Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University of Galati, 800008 Galati, Romania. FAU - Voinescu, Doina Carina AU - Voinescu DC AD - Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University of Galati, 800008 Galati, Romania. FAU - Nechita, Aurel AU - Nechita A AD - Faculty of Medicine and Pharmacy, 'Dunarea de Jos' University of Galati, 800008 Galati, Romania. LA - eng GR - VAT number RO50411550/"Dunarea de Jos" University of Galati/ PT - Journal Article DEP - 20251218 PL - Switzerland TA - Diagnostics (Basel) JT - Diagnostics (Basel, Switzerland) JID - 101658402 PMC - PMC12731802 OTO - NOTNLM OT - anthropometry OT - biological markers OT - elite youth football OT - injury prevention OT - physical performance OT - risk management COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:41 MHDA- 2025/12/30 07:42 PMCR- 2025/12/18 CRDT- 2025/12/30 01:57 PHST- 2025/10/31 00:00 [received] PHST- 2025/12/08 00:00 [revised] PHST- 2025/12/16 00:00 [accepted] PHST- 2025/12/30 07:42 [medline] PHST- 2025/12/30 07:41 [pubmed] PHST- 2025/12/30 01:57 [entrez] PHST- 2025/12/18 00:00 [pmc-release] AID - diagnostics15243238 [pii] AID - diagnostics-15-03238 [pii] AID - 10.3390/diagnostics15243238 [doi] PST - epublish SO - Diagnostics (Basel). 2025 Dec 18;15(24):3238. doi: 10.3390/diagnostics15243238. PMID- 41463299 OWN - NLM STAT- MEDLINE DCOM- 20251230 LR - 20260327 IS - 2218-273X (Electronic) IS - 2218-273X (Linking) VI - 15 IP - 12 DP - 2025 Nov 22 TI - The Possible Role of Neurofilament Light Chain as a Serum Biomarker in Anorexia Nervosa: Clinical Implications. LID - 10.3390/biom15121644 [doi] LID - 1644 AB - BACKGROUND: Neurofilament light chain (NfL) is a well-established biomarker of neuroaxonal damage, detectable in serum through immunoassays. Its potential relevance in psychiatric conditions, including anorexia nervosa (AN), is currently under investigation. This study aims to quantify serum NfL levels in individuals with AN, evaluate their correlation with autoantibodies detection, and critically examine the specificity of NfL as a biomarker in this context. METHODS: A total of 100 participants were enrolled, comprising 50 individuals diagnosed with AN and 50 age-matched, normal-weight controls. Serum concentrations of NfL and immunoglobulin G (IgG) antibodies reactive to hypothalamic antigens were measured using validated immunoassay techniques. RESULTS: Serum NfL concentrations were markedly higher in the AN group compared to healthy controls. Interestingly, NfL levels tended to decrease with longer disease duration and with the recovery of body mass index (BMI), indicating a possible association between clinical improvement and reduced neuroaxonal damage. Furthermore, the results confirmed the presence of anti-hypothalamic autoantibodies and revealed a positive correlation between their levels and serum NfL concentrations. CONCLUSIONS: Clinical remission in AN appears to be linked to a decrease in both markers neuronal damage and hypothalamic autoimmunity. However, as elevated serum NfL is observed across a spectrum of neurological and psychiatric disorders, its specificity as a biomarker for AN should be further investigated. While NfL may reflect neuroaxonal injury in AN, its interpretation should be contextualized within a broader clinical and immunological framework. FAU - Amerio, Andrea AU - Amerio A AUID- ORCID: 0000-0002-3439-340X AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy. AD - IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. FAU - Martino, Eleonora AU - Martino E AD - IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. AD - Dietetics and Clinical Nutrition Unit, University of Genoa, 16132 Genoa, Italy. FAU - Strangio, Antonella AU - Strangio A AD - Department of Experimental Medicine (DiMeS), Section of Human Anatomy, University of Genoa, 16132 Genoa, Italy. FAU - Aguglia, Andrea AU - Aguglia A AUID- ORCID: 0000-0002-2003-2101 AD - Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DiNOGMI), Section of Psychiatry, University of Genoa, 16132 Genoa, Italy. AD - IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. FAU - Conio, Benedetta AU - Conio B AD - IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. FAU - Sukkar, Samir Giuseppe AU - Sukkar SG AUID- ORCID: 0000-0003-4194-1547 AD - IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. AD - Dietetics and Clinical Nutrition Unit, University of Genoa, 16132 Genoa, Italy. FAU - Saverino, Daniele AU - Saverino D AUID- ORCID: 0000-0002-1623-1116 AD - IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. AD - Department of Experimental Medicine (DiMeS), Section of Human Anatomy, University of Genoa, 16132 Genoa, Italy. LA - eng PT - Journal Article DEP - 20251122 PL - Switzerland TA - Biomolecules JT - Biomolecules JID - 101596414 RN - 0 (Neurofilament Proteins) RN - 0 (Biomarkers) RN - 0 (neurofilament protein L) RN - 0 (Autoantibodies) RN - 0 (Immunoglobulin G) SB - IM MH - Humans MH - *Anorexia Nervosa/blood MH - *Neurofilament Proteins/blood MH - *Biomarkers/blood MH - Female MH - Adult MH - Young Adult MH - Adolescent MH - Autoantibodies/blood MH - Male MH - Case-Control Studies MH - Hypothalamus/immunology/metabolism MH - Immunoglobulin G/blood PMC - PMC12730367 OTO - NOTNLM OT - anorexia nervosa OT - anti-hypothalamus antibody OT - neurofilament light chain COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:40 MHDA- 2025/12/30 07:41 PMCR- 2025/11/22 CRDT- 2025/12/30 01:45 PHST- 2025/10/20 00:00 [received] PHST- 2025/11/16 00:00 [revised] PHST- 2025/11/20 00:00 [accepted] PHST- 2025/12/30 07:41 [medline] PHST- 2025/12/30 07:40 [pubmed] PHST- 2025/12/30 01:45 [entrez] PHST- 2025/11/22 00:00 [pmc-release] AID - biom15121644 [pii] AID - biomolecules-15-01644 [pii] AID - 10.3390/biom15121644 [doi] PST - epublish SO - Biomolecules. 2025 Nov 22;15(12):1644. doi: 10.3390/biom15121644. PMID- 41462845 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260102 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 12 DP - 2025 Dec 17 TI - Targeting Pediatric Obesity Through Gender-Specific Nutritional Strategies: Insights from Dietary Intake and Food Sources. LID - 10.3390/children12121705 [doi] LID - 1705 AB - Background/Objectives: Childhood obesity remains a major global health challenge influenced by poor dietary patterns and excessive energy intake. Understanding gender-specific nutritional deviations may improve the effectiveness of preventive and therapeutic interventions. This study aimed to evaluate differences in energy and nutrient intake between boys and girls with overweight or obesity status and to identify the main food sources contributing to these differences. Methods: Data from a total of 180 participants (83 boys, 97 girls; 7-18 years) attending the national obesity intervention program Camp My Challenge was analyzed. Anthropometric parameters and dietary intake were assessed using a validated food-frequency questionnaire (OPKP). Intakes were compared with Slovenian dietary reference values (DRVs). Group differences were tested using ANOVA, t-tests, and Pearson correlations (p < 0.05). Results: Boys exhibited higher body mass (79.9 +/- 22.6 kg vs. 69.2 +/- 19.1 kg; p = 0.001) and BMI (30.8 +/- 4.8 kg/m(2) vs. 28.5 +/- 4.4 kg/m(2); p = 0.001). Mean energy intake was 2543 +/- 1138 kcal/day, exceeding DRV by 16% (t = 3.31, p < 0.001). Girls exceeded energy requirements by 24.5% vs. 5.4% in boys (p = 0.019). Boys consumed significantly more total fat (106 +/- 61 g vs. 85 +/- 47 g; p = 0.014), saturated fatty acids (34 +/- 20 g vs. 27 +/- 13 g; p = 0.011), protein (119 +/- 63 g vs. 98 +/- 41 g; p = 0.008), and sodium (3628 +/- 2086 mg vs. 2852 +/- 1520 mg; p = 0.005). Girls showed higher sugar intake (208% vs. 166% of DRV; p = 0.032), mainly from sweet foods (24%) and fruit (26%), whereas beverages-predominantly isotonic drinks-accounted for 27% of boys' sugar intake. Sugar intake correlated with waist circumference (r = 0.305, p = 0.002) and fat mass (r = 0.272, p = 0.007) in girls. Sodium intake exceeded DRV sixfold in both sexes. Conclusions: Marked sex-specific dietary disparities exist among children with obesity. Interventions should target high sugar and energy intake in girls and excessive fat, sodium, and sugar-sweetened beverage consumption in boys to enhance the efficacy of pediatric obesity management. FAU - Jakus, Tadeja AU - Jakus T AUID- ORCID: 0000-0001-8784-9178 AD - Faculty of Health Sciences, University of Primorska, 6310 Izola, Slovenia. FAU - Franetic, Breda Prunk AU - Franetic BP AD - Red Cross Health Resort Slovenia, Debeli Rtic, 6280 Ankaran, Slovenia. FAU - Vatovec, Tamara Poklar AU - Vatovec TP AD - Faculty of Health Sciences, University of Primorska, 6310 Izola, Slovenia. LA - eng PT - Journal Article DEP - 20251217 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12731442 OTO - NOTNLM OT - childhood obesity OT - dietary OT - nutrition OT - sex-specific COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:41 MHDA- 2025/12/30 07:42 PMCR- 2025/12/17 CRDT- 2025/12/30 01:40 PHST- 2025/11/28 00:00 [received] PHST- 2025/12/11 00:00 [revised] PHST- 2025/12/13 00:00 [accepted] PHST- 2025/12/30 07:42 [medline] PHST- 2025/12/30 07:41 [pubmed] PHST- 2025/12/30 01:40 [entrez] PHST- 2025/12/17 00:00 [pmc-release] AID - children12121705 [pii] AID - children-12-01705 [pii] AID - 10.3390/children12121705 [doi] PST - epublish SO - Children (Basel). 2025 Dec 17;12(12):1705. doi: 10.3390/children12121705. PMID- 41462826 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260102 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 12 DP - 2025 Dec 11 TI - Eating Speed and Its Associations with Cardiometabolic Risk Factors in Children. LID - 10.3390/children12121686 [doi] LID - 1686 AB - Background/Objective: Mexico has experienced an increase in the prevalence of overweight and obesity among schoolchildren, predisposing them to type 2 diabetes mellitus. In addition, rapid eating has been increasingly implicated in the dysregulation of appetite control, greater energy intake, and adverse metabolic outcomes in children. Prior evidence indicates that a faster eating pace is associated with excess adiposity and lipid metabolism. This study aimed to compare cardiovascular risk factors (waist circumference, waist-to-height ratio, body mass index (BMI), and lipid profile) among school-aged Mexican children according to self-reported eating speed. Design: Cross-sectional observational study. Setting: Public elementary schools in Mexico. Participants: Ninety school-aged children (52.2% female) aged 6-12 years old. Eating speed was assessed using an adapted and validated self-administered questionnaire. Intervention: No intervention was applied; participants were classified into slow-, normal-, or fast-eating groups according to their usual eating speed as reported in the instrument, which includes questions regarding self-perception and family perception. Main Outcome Measure: The primary outcomes included anthropometric parameters (BMI, waist circumference, and waist-to-height ratio), blood pressure (systolic and diastolic), and biochemical markers of lipid metabolism (triglycerides, total cholesterol, and HDL cholesterol). Analysis: Descriptive statistics were computed, and comparisons across eating speed groups were performed using one-way ANOVA for continuous variables and chi-square tests for categorical data. Statistical significance was set at p < 0.05. Results: Among the 90 children evaluated, 17.7% were classified as fast eaters. Although gender differences in eating speed were not statistically significant (chi(2)= 4.607, p = 0.100), a higher proportion of boys were classified as fast eaters. Children in the fast-eating group exhibited significantly higher BMI (1.4 kg/m(2)), waist circumference (4 cm greater), and modest elevations in triglyceride and total cholesterol levels, alongside lower HDL cholesterol, relative to their slow-eating peers (all p < 0.05). Among all variables, only diastolic blood pressure differed significantly across groups (F = 3.92, p = 0.022), with fast eaters showing the highest values. Nevertheless BMI, waist circumference, triglyceride levels, and total cholesterol were not statistically significant in the logistic regression, and HDL cholesterol demonstrated an association close to 95% [0.051 (0.011-0.226)] to a protective factor against cardiometabolic events, estimating an effect size of 1.64 using Cohen's d, which is considered a large effect, when compared to their slower-eating peers. Conclusions and Implications: Faster eating speed was consistently associated with unfavorable anthropometric and lipid profile indicators, aligning with previous evidence linking rapid eating to early cardiometabolic alterations. These findings emphasize the relevance of including eating behavior assessments in pediatric cardiovascular risk screenings and prevention strategies. FAU - Gomez-Martinez, Manuel Abraham AU - Gomez-Martinez MA AUID- ORCID: 0000-0001-9460-0848 AD - Promotion and Education for Health and Food Research Group, Universidad La Salle Mexico, Benjamin Franklin 45, Colonia Condesa, Mexico City 06140, Mexico. AD - Public Health Department, Faculty of Medicine, National University of Mexico, Escolar 411A, Copilco Universidad, Coyoacan, Mexico City 04360, Mexico. FAU - Rodriguez-Vera, Diana AU - Rodriguez-Vera D AUID- ORCID: 0000-0002-5526-0489 AD - Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina del Instituto Politecnico Nacional, Plan de San Luis y Diaz Miron s/n, Mexico City 11340, Mexico. AD - Clinica de Nutricion Especializada Beke, Colonia San Sebastian, Texcoco 56130, Mexico. FAU - Mendoza, Gabriela Olivares AU - Mendoza GO AD - Programa de Maestria en Ciencia de los Alimentos y Nutricion Humana, Facultad de Ciencias Quimicas, Universidad La Salle Mexico, Mexico City 06140, Mexico. FAU - Lastiri, Fernanda Lobato AU - Lastiri FL AUID- ORCID: 0000-0002-7120-9309 AD - Promotion and Education for Health and Food Research Group, Universidad La Salle Mexico, Benjamin Franklin 45, Colonia Condesa, Mexico City 06140, Mexico. FAU - Morales-Gonzalez, Jose A AU - Morales-Gonzalez JA AUID- ORCID: 0000-0002-5980-0980 AD - Laboratorio de Medicina de Conservacion, Escuela Superior de Medicina del Instituto Politecnico Nacional, Plan de San Luis y Diaz Miron s/n, Mexico City 11340, Mexico. FAU - Pinto-Almazan, Rodolfo AU - Pinto-Almazan R AUID- ORCID: 0000-0002-5210-5395 AD - Seccion de Estudios de Posgrado e Investigacion, Escuela Superior de Medicina del Instituto Politecnico Nacional, Plan de San Luis y Diaz Miron s/n, Mexico City 11340, Mexico. AD - Fundacion Vithas, Grupo Hospitalario Vithas, 28043 Madrid, Spain. FAU - Vergara-Castaneda, Arely AU - Vergara-Castaneda A AUID- ORCID: 0000-0002-9366-3211 AD - Promotion and Education for Health and Food Research Group, Universidad La Salle Mexico, Benjamin Franklin 45, Colonia Condesa, Mexico City 06140, Mexico. LA - eng GR - Q097/13/Universidad La Salle/ PT - Journal Article DEP - 20251211 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12732249 OTO - NOTNLM OT - cardiovascular risk factors OT - chronic diseases OT - eating behaviors OT - lipid profile OT - school-aged children COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:41 MHDA- 2025/12/30 07:42 PMCR- 2025/12/11 CRDT- 2025/12/30 01:40 PHST- 2025/11/01 00:00 [received] PHST- 2025/12/05 00:00 [revised] PHST- 2025/12/09 00:00 [accepted] PHST- 2025/12/30 07:42 [medline] PHST- 2025/12/30 07:41 [pubmed] PHST- 2025/12/30 01:40 [entrez] PHST- 2025/12/11 00:00 [pmc-release] AID - children12121686 [pii] AID - children-12-01686 [pii] AID - 10.3390/children12121686 [doi] PST - epublish SO - Children (Basel). 2025 Dec 11;12(12):1686. doi: 10.3390/children12121686. PMID- 41462786 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260102 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 12 DP - 2025 Dec 3 TI - Evaluating an Eight-Week Therapeutic Swimming Program in Children with Autism Spectrum Disorder: A Mixed-Methods Study from Romania. LID - 10.3390/children12121646 [doi] LID - 1646 AB - Background/Objectives: In Romania, therapeutic program programs for children with autism spectrum disorder (ASD) focus mainly on behavioral and educational approaches, with limited integration of adapted physical activity (APA). Therapeutic swimming may provide complementary benefits, addressing both physical and psychosocial challenges. This study explored parent-perceived changes across an adapted therapeutic swimming program, following ABA therapy, on the well-being, learning, attention, physical activity, and social functioning of children with ASD. A custom-developed parent-report tool (PPQ-Autism-Swim) was used to measure perceived changes across key developmental domains. Methods: Thirty-nine children with ASD were recruited, of whom 36 completed the full 8-week swimming intervention. Parent-report questionnaires, developed by behavioral therapists under the supervision of a clinical psychologist, were administered at three time points: 8 weeks before swimming (T - 8), immediately before swimming after Applied Behaviour Analysis (ABA) therapy (T0), and 8 weeks after swimming (T + 8). The questionnaire assessed five subscales: general well-being, physical activity and energy, attention and focus, learning and cognitive progress, and self-confidence and social behaviors. Data were analyzed using descriptive statistics, repeated-measures ANOVA, and thematic analysis of qualitative parental feedback. ABA therapy served as a behavioral baseline, allowing comparison with subsequent gains from swimming. Results: Parents reported higher scores across time points, suggesting perceived changes in several domains. From T - 8 to T0, moderate gains followed ABA therapy, while from T0 to T + 8, therapeutic swimming was associated with improvements. At T + 8, 35 of 36 children showed measurable progress, particularly in physical activity regulation and self-confidence. Parental feedback emphasized calmer behavior, improved sleep, increased social interaction, and greater pride in new skills. Reliability testing indicated good to excellent internal consistency (Cronbach's alpha = 0.78-0.91). Conclusions: Therapeutic swimming appears to be an effective and motivating form of adapted physical education, complementing behavioral therapies and addressing multiple developmental challenges in children with ASD. FAU - Alecu, Stefan AU - Alecu S AUID- ORCID: 0009-0002-2252-4238 AD - Department of Physical Education and Special Motricity, Faculty of Physical Education and Mountain Sports, Transilvania University, 500068 Brasov, Romania. FAU - Onea, Gheorghe Adrian AU - Onea GA AUID- ORCID: 0009-0004-4441-9791 AD - Department of Physical Education and Special Motricity, Faculty of Physical Education and Mountain Sports, Transilvania University, 500068 Brasov, Romania. LA - eng PT - Journal Article DEP - 20251203 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12732067 OTO - NOTNLM OT - Romanian OT - adapted physical activity OT - aquatic therapy OT - autism spectrum disorder OT - child development OT - parental perception OT - therapeutic swimming COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:40 MHDA- 2025/12/30 07:41 PMCR- 2025/12/03 CRDT- 2025/12/30 01:39 PHST- 2025/10/22 00:00 [received] PHST- 2025/11/23 00:00 [revised] PHST- 2025/12/02 00:00 [accepted] PHST- 2025/12/30 07:41 [medline] PHST- 2025/12/30 07:40 [pubmed] PHST- 2025/12/30 01:39 [entrez] PHST- 2025/12/03 00:00 [pmc-release] AID - children12121646 [pii] AID - children-12-01646 [pii] AID - 10.3390/children12121646 [doi] PST - epublish SO - Children (Basel). 2025 Dec 3;12(12):1646. doi: 10.3390/children12121646. PMID- 41462770 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260102 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 12 DP - 2025 Dec 1 TI - Mindful Parenting and Picky Eating Behaviors in Early Childhood: Parental Dietary Competence as a Mediator. LID - 10.3390/children12121629 [doi] LID - 1629 AB - Background: Picky eating behaviors among children challenge nutritional intake and healthy development and place considerable stress on parents. Parenting approaches play a critical role in shaping young children's dietary behaviors. Mindful parenting, which refers to parents responding to their child's needs with awareness, acceptance, attention, and mindful discipline, has gained increasing attention. Parental dietary competence may determine whether mindful parenting effectively discourages picky eating behavior in children. Objectives: This study explored whether mindful parenting and parental dietary competence are associated with picky eating behaviors in young children. The mediating role of parental dietary competence in this association was also investigated. Methods: A total of 412 parents of children enrolled in six preschools across six administrative districts in New Taipei City, Taipei City, and Taoyuan City, Taiwan, were invited and recruited. Data were collected using three validated parent-reported instruments, including a mindful parenting scale, parental dietary competence scale, and children's picky eating behaviors scale. Results: Mindful parenting influenced children's picky eating behaviors through the full mediation of parental dietary competence. The identification of parental dietary competence as a mediator underscores the need for early preventive interventions and parenting education that integrate parental mindfulness and dietary competence to foster healthy eating habits from the outset of early childhood. Conclusions: Practical recommendations and future research directions are provided regarding mindful parenting, parental dietary competence, and picky eating behaviors in young children. FAU - Chen, Jo-Lin AU - Chen JL AD - Child and Family Studies, Fu Jen Catholic University, New Taipei City 242062, Taiwan. FAU - Chen, Su-Ping AU - Chen SP AD - Department of Living Services Industry, Tainan University of Technology, Tainan City 71002, Taiwan. FAU - Doong, Jia-Yau AU - Doong JY AUID- ORCID: 0000-0003-0365-3915 AD - Nutritional Science Studies, Fu Jen Catholic University, New Taipei City 242062, Taiwan. FAU - Huang, Shou-Chi AU - Huang SC AUID- ORCID: 0009-0001-9540-5283 AD - Child and Family Studies, Fu Jen Catholic University, New Taipei City 242062, Taiwan. LA - eng PT - Journal Article DEP - 20251201 PL - Switzerland TA - Children (Basel) JT - Children (Basel, Switzerland) JID - 101648936 PMC - PMC12731706 OTO - NOTNLM OT - early childhood OT - healthy eating habits OT - mindful parenting OT - parental dietary competence OT - parenting approaches OT - picky eating behaviors COIS- The authors declare no conflicts of interest. EDAT- 2025/12/30 07:40 MHDA- 2025/12/30 07:41 PMCR- 2025/12/01 CRDT- 2025/12/30 01:39 PHST- 2025/10/10 00:00 [received] PHST- 2025/11/14 00:00 [revised] PHST- 2025/11/25 00:00 [accepted] PHST- 2025/12/30 07:41 [medline] PHST- 2025/12/30 07:40 [pubmed] PHST- 2025/12/30 01:39 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - children12121629 [pii] AID - children-12-01629 [pii] AID - 10.3390/children12121629 [doi] PST - epublish SO - Children (Basel). 2025 Dec 1;12(12):1629. doi: 10.3390/children12121629. PMID- 41462756 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251230 LR - 20260102 IS - 2227-9067 (Print) IS - 2227-9067 (Electronic) IS - 2227-9067 (Linking) VI - 12 IP - 12 DP - 2025 Nov 27 TI - Computing and Evaluating Relationships Between Equal and Differential Factor Weighting for Fundamental Movement Skills and Physical Activity with Guided Active Play During Childhood. LID - 10.3390/children12121615 [doi] LID - 1615 AB - Background/Objectives: The Test of Gross Motor Development (TGMD-2) totals assume equal weighting of the 12 locomotor (LOC) and object control (OC) skills, yet validation studies indicate differential contributions. The study compared equal- and differential-weighted scores for LOC and OC skills, with three fitness and two physical activity (PA) outputs during guided active play (GAP). Methods: Children's (n = 82; 7.6 +/- 1.5 years) TGMD-2 LOC and OC differential factor weights were estimated with Exploratory Factor Analysis (EFA) and compared to equal weights with multiple linear regression (two, five, and eight predictors) and Chi-square analyses. Predictor variables included fitness, BMI, sex, age stages, and PA assessed by energy expenditure (PAEE) and intensity (MVPA) estimated using accelerometry during 1 h GAP. Results: EFA supported a two-factor structure (variance explained = 51.1%) with >/=0.500 loadings for 9/12 skills. Differential- and equal-weighted LOC and OC scores showed varied contributions from individual skills. Multiple linear regression analysis showed similar explained variances (R(2)) of 53% (PAEE), 40% (MVPA), 31% (OC), and 14% (LOC) for equal or differential scores with eight predictors. Although beta coefficients varied, going from two, five, and eight predictors, the impact of equal and differential weights was comparable. Chi-square analysis indicated high OC associated with MVPA (X(2) (4) = 9.42, p /=2.5). CONCLUSIONS: A proinflammatory diet is associated with lower fecundability in multiethnic Asian women without known infertility. Further studies are needed to clarify the role of insulin resistance in this relationship. CI - Copyright (c) 2025 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Loh, Jason AU - Loh J AD - Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore. FAU - Yu, Guoqi AU - Yu G AD - Global Centre for Asian Women's Health, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. FAU - Colega, Marjorelee T AU - Colega MT AD - Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore. FAU - Tan, Karen AU - Tan K AD - Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore. FAU - Chong, Yap Seng AU - Chong YS AD - Department of Obstetrics and Gynaecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore. FAU - Godfrey, Keith M AU - Godfrey KM AD - MRC Lifecourse Epidemiology Centre & NIHR Southampton Biomedical Research Centre, University of Southampton & University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom. FAU - Chan, Jerry Kok Yen AU - Chan JKY AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore; Duke-NUS Medical School, Singapore; SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore. FAU - Chan, Shiao-Yng AU - Chan SY AD - Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore; Department of Obstetrics & Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore. FAU - Eriksson, Johan G AU - Eriksson JG AD - Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore; Department of Obstetrics & Gynaecology and Human Potential Translational Research Programme, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore; Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, & Folkhalsan Research Center, University of Helsinki, Helsinki, Finland. FAU - Chong, Mary Ff AU - Chong MF AD - Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore. FAU - Loy, See Ling AU - Loy SL AD - Department of Reproductive Medicine, KK Women's and Children's Hospital, Singapore; Duke-NUS Medical School, Singapore; SingHealth Duke-NUS Maternal and Child Health Research Institute, KK Women's and Children's Hospital, Singapore. FAU - Lai, Jun S AU - Lai JS AD - Institute for Human Development and Potential, Agency for Science, Technology and Research, Singapore. Electronic address: lai_jun_shi@sics.a-star.edu.sg. LA - eng GR - MC_UU_12011/4/MRC_/Medical Research Council/United Kingdom PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251227 PL - United States TA - J Nutr JT - The Journal of nutrition JID - 0404243 RN - 9007-41-4 (C-Reactive Protein) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Adult MH - *Diet/adverse effects MH - Singapore MH - *Inflammation MH - C-Reactive Protein/metabolism MH - *Fertility MH - Asian People MH - Cohort Studies MH - Pregnancy MH - Biomarkers/blood MH - Insulin Resistance OTO - NOTNLM OT - empirical dietary inflammatory pattern OT - fecundability OT - fertility OT - time-to-pregnancy OT - women COIS- Conflict of interest YSC reports financial support was provided by National Medical Research Council. KMG reports financial support was provided by UK Research and Innovation Medical Research Council. KMG reports financial support was provided by National Institute for Health Research. KMG reports financial support was provided by European Union. KMG reports a relationship with EpiGen Consortium that includes: speaking and lecture fees and travel reimbursement. YSC reports a relationship with EpiGen Consortium that includes: speaking and lecture fees and travel reimbursement. All other authors report no conflicts of interest. EDAT- 2025/12/30 00:30 MHDA- 2026/02/17 00:53 CRDT- 2025/12/29 19:27 PHST- 2025/08/04 00:00 [received] PHST- 2025/12/14 00:00 [revised] PHST- 2025/12/22 00:00 [accepted] PHST- 2026/02/17 00:53 [medline] PHST- 2025/12/30 00:30 [pubmed] PHST- 2025/12/29 19:27 [entrez] AID - S0022-3166(25)00789-8 [pii] AID - 10.1016/j.tjnut.2025.101283 [doi] PST - ppublish SO - J Nutr. 2026 Feb;156(2):101283. doi: 10.1016/j.tjnut.2025.101283. Epub 2025 Dec 27. PMID- 41460996 OWN - NLM STAT- In-Process LR - 20251229 IS - 1538-005X (Electronic) IS - 0898-5669 (Linking) VI - 38 IP - 1 DP - 2026 Jan 1 TI - Commentary on "Exploring the Feasibility of a Vestibular/Oculomotor Caregiver-Supervised Exercise Program in Children Post Moderate-Severe Traumatic Brain Injury". PG - 77 LID - 10.1097/PEP.0000000000001276 [doi] FAU - Tiwari, Devashish AU - Tiwari D AD - MGH Institute of Health Professions Department of Physical Therapy Boston, Massachusetts. FAU - Molind, Heather AU - Molind H AD - Department of Physical and Occupational Therapy Boston Children's Hospital Boston, Massachusetts. LA - eng PT - Journal Article DEP - 20251230 PL - United States TA - Pediatr Phys Ther JT - Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association JID - 8912748 SB - IM COIS- The authors declare no conflicts of interest. EDAT- 2025/12/29 19:19 MHDA- 2025/12/29 19:19 CRDT- 2025/12/29 14:33 PHST- 2025/12/29 19:19 [medline] PHST- 2025/12/29 19:19 [pubmed] PHST- 2025/12/29 14:33 [entrez] AID - 00001577-202601000-00015 [pii] AID - 10.1097/PEP.0000000000001276 [doi] PST - ppublish SO - Pediatr Phys Ther. 2026 Jan 1;38(1):77. doi: 10.1097/PEP.0000000000001276. Epub 2025 Dec 30. PMID- 41460995 OWN - NLM STAT- MEDLINE DCOM- 20251229 LR - 20251229 IS - 1538-005X (Electronic) IS - 0898-5669 (Linking) VI - 38 IP - 1 DP - 2026 Jan 1 TI - Exploring the Feasibility of a Vestibular/Oculomotor Caregiver-Supervised Exercise Program in Children Post Moderate-Severe Traumatic Brain Injury. PG - 68-76 LID - 10.1097/PEP.0000000000001249 [doi] AB - PURPOSE: To explore the feasibility of a vestibular/oculomotor caregiver-supervised exercise program in children post moderate-severe traumatic brain injury (TBI). METHODS: The study included 37 children aged 6-18 years, with a median of 42-days post moderate-severe TBI. The intervention-group participated in a vestibular/oculomotor caregiver-supervised exercise program for 8 weeks; the control-group continued with standard-care only. Feasibility was evaluated based on the number of adverse-events and practices reported, and the ability to perform assessments. Vestibular/oculomotor function was evaluated by the number abnormal tests in the Vestibular/Ocular-Motor-Screening. Balance was evaluated by the Pediatric Balance Scale and Functional-Gait-Assessment. RESULTS: All participants completed the tests and no adverse-events were observed during the study. However, only 6 participants in the intervention-group performed >/=80% of the recommended practice. All assessments were significantly improved (P < .05) in both groups, with no significant differences between them. CONCLUSIONS: Although the vestibular/oculomotor caregiver-supervised intervention program was safe, the cooperation-rate was low, indicating difficulties with feasibility. CI - Copyright (c) 2025 Academy of Pediatric Physical Therapy of the American Physical Therapy Association. FAU - Sorek, Gilad AU - Sorek G AUID- ORCID: 0000-0002-5766-0857 AD - Department of Physical Therapy, School of Health Sciences, Ariel University, Ariel, Israel (Dr Sorek); Montreal Children's Hospital, McGill University Health Center, Montreal, Canada (Dr Gagnon); School of Physical and Occupational Therapy, Faculty of Medicine and Health Sciences, McGill University, Montreal, Canada (Dr Gagnon); Sport Injury Research Prevention Centre, Faculty of Kinesiology, University of Calgary, Calgary, Canada (Dr Schneider); Alberta Children's Hospital Research Institute, University of Calgary, Calgary, Canada (Dr Schneider); Hotchkiss Brain Institute, University of Calgary, Calgary, Canada (Dr Schneider); Sorbonne Universite, Laboratoire d'Imagerie Biomedicale, LIB, Inserm, CNRS, Paris, France (Dr Chevignard); Sorbonne Universite, GRC 24 Handicap Moteur et Cognitif et Readaptation, HaMCRe, Paris, France (Dr Chevignard); Rehabilitation Department for Children with Acquired Neurological Injury, Saint Maurice Hospitals, Saint Maurice, France (Dr Chevignard); Alyn Children's Hospital and Rehabilitation Center, Jerusalem, Israel (Ms Stern); Children Rehabilitation Department, Lowenstein Rehabilitation Medical Center Ra'anana, Israel (Ms Fadida, Dr Shaklai); Department of Physical Therapy, Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel (Dr Kalderon, Dr Katz-Leurer). FAU - Gagnon, Isabelle AU - Gagnon I FAU - Schneider, Kathryn AU - Schneider K FAU - Chevignard, Mathilde AU - Chevignard M FAU - Stern, Nurit AU - Stern N FAU - Fadida, Yahaloma AU - Fadida Y FAU - Kalderon, Liran AU - Kalderon L FAU - Shaklai, Sharon AU - Shaklai S FAU - Katz-Leurer, Michal AU - Katz-Leurer M LA - eng PT - Journal Article DEP - 20251230 PL - United States TA - Pediatr Phys Ther JT - Pediatric physical therapy : the official publication of the Section on Pediatrics of the American Physical Therapy Association JID - 8912748 SB - IM MH - Humans MH - Child MH - Adolescent MH - Male MH - Female MH - Feasibility Studies MH - *Exercise Therapy/methods MH - *Brain Injuries, Traumatic/rehabilitation/physiopathology MH - *Caregivers MH - Postural Balance/physiology MH - Vestibule, Labyrinth/physiopathology OTO - NOTNLM OT - balance OT - child OT - feasibility OT - home exercise program OT - traumatic brain injury OT - vestibular/oculomotor rehabilitation COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/29 19:19 MHDA- 2025/12/29 19:20 CRDT- 2025/12/29 14:33 PHST- 2025/12/29 19:20 [medline] PHST- 2025/12/29 19:19 [pubmed] PHST- 2025/12/29 14:33 [entrez] AID - 00001577-202601000-00014 [pii] AID - 10.1097/PEP.0000000000001249 [doi] PST - ppublish SO - Pediatr Phys Ther. 2026 Jan 1;38(1):68-76. doi: 10.1097/PEP.0000000000001249. Epub 2025 Dec 30. PMID- 41460020 OWN - NLM STAT- MEDLINE DCOM- 20260209 LR - 20260610 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2025 Dec 29 TI - The initial development and validation of a child-oriented food literacy questionnaire. PG - e26 LID - 10.1017/S1368980025101651 [doi] LID - e26 AB - OBJECTIVE: The Dutch Children's Food Literacy Questionnaire (DCFLQ) was developed and validated to assess food literacy among children aged 8-12 years. The DCFLQ is structured around farm-to-fork principles, including questions on food production, distribution, consumption, waste, and sustainability. DESIGN: After initial item pool creation, the DCFLQ was developed in collaboration with experts and children. The validation process included assessments of reliability and construct validity, as well as a test-retest evaluation in a subgroup of children. SETTING: The expert panel consisted of domain-related researchers, a pedagogue, a paediatrician, dietitians and a primary school teacher. Children were recruited via primary schools and a sports club. PARTICIPANTS: A total of eleven experts and twenty-seven children participated in the development process; 608 children participated in the validation process. RESULTS: The final questionnaire comprised twenty-nine questions and demonstrated good internal consistency (Cronbach's alpha = 0.80) and test-retest reliability (ICC = 0.81). DCFLQ scores positively correlated with age, indicating that food literacy is higher in older children. CONCLUSIONS: The DCFLQ is a valuable tool for assessing the effectiveness of nutrition intervention programmes and monitoring Dutch children's food literacy over time. International expert consensus on developing food literacy instruments is needed, as diversity in assessment tools impedes cross-cultural comparisons. FAU - van Lier, Ilse AU - van Lier I AUID- ORCID: 0000-0001-8381-1252 AD - Chair Group Youth, Food & Health, https://ror.org/02jz4aj89Maastricht University Campus Venlo, Venlo, the Netherlands. FAU - van Belkom, Britt AU - van Belkom B AD - Chair Group Youth, Food & Health, https://ror.org/02jz4aj89Maastricht University Campus Venlo, Venlo, the Netherlands. FAU - van Mil, Edgar AU - van Mil E AD - Chair Group Youth, Food & Health, https://ror.org/02jz4aj89Maastricht University Campus Venlo, Venlo, the Netherlands. AD - Department of Paediatrics, Children's Lifestyle Medicine Centre, Jeroen Bosch Hospital, 's-Hertogenbosch, the Netherlands. FAU - Havermans, Remco AU - Havermans R AUID- ORCID: 0000-0001-5832-8357 AD - Chair Group Youth, Food & Health, https://ror.org/02jz4aj89Maastricht University Campus Venlo, Venlo, the Netherlands. AD - Laboratory of Behavioural Gastronomy, Maastricht University Campus Venlo, Venlo, the Netherlands. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20251229 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - Child MH - Surveys and Questionnaires/standards MH - Reproducibility of Results MH - Netherlands MH - Male MH - Female MH - *Health Literacy MH - *Diet PMC - PMC12895494 OTO - NOTNLM OT - Children OT - Farm-to-fork OT - Food literacy OT - Instrument development OT - Questionnaire COIS- There are no conflicts of interest. EDAT- 2025/12/29 13:02 MHDA- 2026/02/09 06:30 PMCR- 2025/12/29 CRDT- 2025/12/29 08:43 PHST- 2026/02/09 06:30 [medline] PHST- 2025/12/29 13:02 [pubmed] PHST- 2025/12/29 08:43 [entrez] PHST- 2025/12/29 00:00 [pmc-release] AID - S1368980025101651 [pii] AID - 10.1017/S1368980025101651 [doi] PST - epublish SO - Public Health Nutr. 2025 Dec 29;29(1):e26. doi: 10.1017/S1368980025101651. PMID- 41459087 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251229 LR - 20251231 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Development and validation of age- and sex-specific reference intervals for serum vitamin B5 in Henan pediatric population by LC-MS/MS. PG - 1698679 LID - 10.3389/fnut.2025.1698679 [doi] LID - 1698679 AB - BACKGROUND AND OBJECTIVE: Reference intervals (RIs) for serum vitamin B5 (pantothenic acid, B5) specific to the Henan pediatric population have not been established. Current clinical practice, in China continues to rely on reference thresholds derived from international populations. However, these generalized intervals may lack diagnostic accuracy and relevance when applied to domestic children. This study aims to establish age- and sex-specific RIs for serum B5 in Henan children aged 1-17 years, thereby enhancing the reliability of clinical assessments and nutritional evaluations. METHODS: This cross-sectional study involved 1,998 healthy children who underwent routine physical examinations between January 2022 and March 2025. Serum B5 concentrations were quantified using liquid chromatography-tandem mass spectrometry (LC-MS/MS) system. Data exhibiting non-normal distribution are expressed as median and interquartile range (IQR) [M (P(25), P(75))]. Age- and sex-related differences were analyzed using the Mann-Whitney U test or Kruskal-Wallis test, as appropriate. RIs validation was performed using a subsequent cohort (n = 547) examined from March to May 2025. RESULTS: Age and sex were identified as significant factors influencing serum B5 concentrations in the pediatric cohort. The study population had a predominance proportion of male participants (59.01%, 1,179/1,998), and most subjects were under the age of 12, reflecting a primarily prepubescent sample (93.59%, 1,870/1,970). Based on these demographic characteristics, further stratified analyses were conducted to establish age- and sex-specific RIs for serum B5 levels. For male children, the RIs were 31.57-169.31 ng/mL for the 1-5-year age group, 24.23-127.57 ng/mL for those aged 6-11 years, and 25.36-95.37 ng/mL for those aged 12 and older. Female participants showed RIs of 31.10-166.20 ng/mL, 23.93-114.79 ng/mL, and 18.56-122.55 ng/mL for the same age categories. These stratified intervals highlight the importance of considering both age and sex in the clinical interpretation of pediatric B5 measurements. Validation results confirmed the reliability of the established reference intervals, demonstrating a minimum conformity rate of 93.94%, which meets the 90% threshold stipulated by Chinese industry standards. CONCLUSION: This study provides the first comprehensive set of age- and sex-specific RIs for serum B5 in Chinese children aged 1-17 years and has validated them in a representative cohort. CI - Copyright (c) 2025 Luan, Li, Lin, Li and Yang. FAU - Luan, Yusheng AU - Luan Y AD - Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China. AD - Zhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China. FAU - Li, Tiewei AU - Li T AD - Zhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China. FAU - Lin, Fatao AU - Lin F AD - Key Laboratory of Children's Infection and Immunity, Department of Neonatal Medicine, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China. FAU - Li, Xiaojuan AU - Li X AD - Zhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China. FAU - Yang, Junmei AU - Yang J AD - Zhengzhou Key Laboratory of Children's Infection and Immunity, Department of Clinical Laboratory, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, China. LA - eng PT - Journal Article DEP - 20251211 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12739956 OTO - NOTNLM OT - Henan OT - children OT - reference intervals OT - validation OT - vitamin B5 COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/29 07:08 MHDA- 2025/12/29 07:09 PMCR- 2025/12/11 CRDT- 2025/12/29 05:17 PHST- 2025/09/04 00:00 [received] PHST- 2025/11/21 00:00 [revised] PHST- 2025/11/26 00:00 [accepted] PHST- 2025/12/29 07:09 [medline] PHST- 2025/12/29 07:08 [pubmed] PHST- 2025/12/29 05:17 [entrez] PHST- 2025/12/11 00:00 [pmc-release] AID - 10.3389/fnut.2025.1698679 [doi] PST - epublish SO - Front Nutr. 2025 Dec 11;12:1698679. doi: 10.3389/fnut.2025.1698679. eCollection 2025. PMID- 41458819 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251229 LR - 20251231 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 11 DP - 2025 Nov TI - Missed Opportunities in Maternal Care: A Cross-Sectional Study of Utilisation of Anganwadi Services in Central India. PG - e97869 LID - 10.7759/cureus.97869 [doi] LID - e97869 AB - Introduction The Government of India has initiated several programs to enhance maternal health. Despite comprehensive operations and significant governmental backing, the usage of nutrition aid and healthcare services from Anganwadi Centres for pregnant and breastfeeding women remains inconsistent and insufficient in various locations. Objectives The primary objective was to investigate the factors influencing the utilization of these services and to explore the reasons for non-utilization. Methodology This was a cross-sectional observational study, intended to evaluate the utilization of Anganwadi services among pregnant and breastfeeding mothers in Central India. A total of 365 pregnant women and lactating mothers were interviewed using a face-validated questionnaire covering demographic characteristics, awareness of Anganwadi services, and factors influencing utilization. Results The study participants were maximum in the age range of 20 to 30 years, with 35.8% had done graduation. About 61.91% of participants had a spouse qualification of less than graduation. The utilization rate of Anganwadi services among the study participants was around 91%. However, challenges such as logistical barriers, concerns about service quality, and disparities in access persisted. Statistical analysis indicated a significant association between these factors and service utilization (p < 0.05). Conclusion The findings have highlighted the need for targeted interventions to ensure equitable access to maternal and child healthcare services and have significant implications for policy development and program planning. CI - Copyright (c) 2025, Choudhary et al. FAU - Choudhary, Amruta AU - Choudhary A AD - Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Nagpur, Nagpur, IND. FAU - Yadav, Anita AU - Yadav A AD - Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Nagpur, Nagpur, IND. FAU - Rangrej, Rubina Bano AU - Rangrej RB AD - Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Nagpur, Nagpur, IND. FAU - Sanap, Arun S AU - Sanap AS AD - Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Nagpur, Nagpur, IND. FAU - Khan, Mubashara AU - Khan M AD - Department of Community Medicine, All India Institute of Medical Sciences, Nagpur, Nagpur, IND. FAU - Kamath, Anusha AU - Kamath A AD - Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Nagpur, Nagpur, IND. FAU - Gangane, Neha N AU - Gangane NN AD - Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Nagpur, Nagpur, IND. FAU - Mundle, Shuchita AU - Mundle S AD - Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Nagpur, Nagpur, IND. LA - eng PT - Journal Article DEP - 20251126 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12742674 OTO - NOTNLM OT - aganwadi services OT - healthcare utilisation OT - icds OT - non utilisation OT - supplementary nutrition COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Institutional Ethics Committee, All India Institute of Medical Sciences, Nagpur issued approval IEC/Pharmac/2023/648. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/12/29 07:08 MHDA- 2025/12/29 07:09 PMCR- 2025/11/26 CRDT- 2025/12/29 05:14 PHST- 2025/11/26 00:00 [accepted] PHST- 2025/12/29 07:09 [medline] PHST- 2025/12/29 07:08 [pubmed] PHST- 2025/12/29 05:14 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - 10.7759/cureus.97869 [doi] PST - epublish SO - Cureus. 2025 Nov 26;17(11):e97869. doi: 10.7759/cureus.97869. eCollection 2025 Nov. PMID- 41458784 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251229 LR - 20251231 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 11 DP - 2025 Nov TI - Utilization of Hematological Markers to Distinguish Bile Reflux Gastritis From Helicobacter pylori-Associated Gastritis in Pediatric Patients. PG - e97817 LID - 10.7759/cureus.97817 [doi] LID - e97817 AB - Gastritis is a frequent pediatric disease and is associated with significant morbidity, nutritional compromise and reduction in the quality of life. Among the etiologies, Helicobacter pylori (H. pylori) gastritis and bile reflux gastritis (BRG) are most frequent though clinically indistinguishable without invasive examinations like biopsy. This prospective observational cross-sectional study was carried out at the Department of Pediatric Gastroenterology, Jinnah Postgraduate Medical Centre (JPMC), Karachi, aiming to elaborate the diagnostic utility of these hematological markers in differentiating BRG from H. pylori gastritis. One hundred twenty children aged five to 15 years with endoscopically and histologically confirmed gastritis were recruited from January to December 2024, of which the BRG (n = 60) and H. pylori gastritis (n = 60) groups had equal number of participants. Research data was gathered with the help of a structured proforma, endoscopic examination and confirmed by biopsy from pretreatment blood samples. The determined hematologic parameters were as follows: hemoglobin (Hb), total leukocyte count (TLC), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), mean corpuscular volume (MCV), red cell distribution width (RDW) and platelet counts. t-tests, Chi-square tests, Mann-Whitney U tests and receiver operating characteristic (ROC) curve analyses were used for statistical analysis. The children with H. pylori gastritis demonstrated lower levels of hemoglobin (10.9+/-1.2 g/dL vs 11.8+/-1.3 g/dL, p=0.001), MCV (80.1+/-5.7 fL vs 82.6+/-6.2 fL, p=0.04) and higher RDW (15.6+/-2.0% vs 14.5+/-1.9%, p=0.003), indicating iron-deficiency with microcytic anemia in the former group than the latter groups respectively with no such differences seen among patients who were Helicobacter free. On the other hand, NLR was significantly higher in BRG patients (2.6+/-0.8 vs 2.1+/-0.7, p=0.001), reflecting an increased neutrophil-mediated inflammation. PLR was higher in H. pylori gastritis (148.7+/-34.2 vs 131.5+/-29.1, p=0.02), whereas platelet counts were similar between the two groups (p=0.21). By ROC analysis, NLR (area under the curve (AUC)=0.72) and RDW (AUC=0.70) were the best discriminative factors, as well as hemoglobin level (AUC=0.68). These results indicated that the simple and inexpensive hematological parameters NLR, RDW, and Hb could have clinical application value as adjuncts for distinguishing between BRG children and H. pylori gastritis patients. An approach like this might reduce the use of invasive procedures, increase diagnostic accuracy, and help in clinical decision making, particularly in low-resource health care settings. CI - Copyright (c) 2025, Muhammad Arqam et al. FAU - Muhammad Arqam, Shehanshah AU - Muhammad Arqam S AD - Medicine, Dow University of Health Sciences, Karachi, PAK. FAU - Mahmood, Maliha AU - Mahmood M AD - Medicine, Balouchistan Institute of Child Health Services, Quetta, PAK. FAU - Khowaja, Labiqa AU - Khowaja L AD - Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, PAK. FAU - Ul Haq, Naveed AU - Ul Haq N AD - Medicine, Khyber Teaching Hospital, Peshawar, PAK. FAU - Ullah, Farhan AU - Ullah F AD - Medicine, Khyber Teaching Hospital, Peshawar, PAK. FAU - Kumar, Akshy AU - Kumar A AD - Medicine, Liaquat University of Medical and Health Sciences, Jamshoro, PAK. FAU - Rehman, Muhammad Tayyab AU - Rehman MT AD - Medicine, Pakistan Navy Ship (PNS) Shifa Hospital, Karachi, PAK. FAU - Sohail, Raheel Ahmad AU - Sohail RA AD - Medicine, Shaikh Zayed Hospital, Lahore, PAK. FAU - Khan, Muhammad Hamza AU - Khan MH AD - Medicine, Dow University of Health Sciences, Dow International Medical College, Karachi, PAK. FAU - Khan, Ali AU - Khan A AD - Medicine, Jinnah Postgraduate Medical Centre, Karachi, PAK. LA - eng PT - Journal Article DEP - 20251125 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12741569 OTO - NOTNLM OT - bile reflux gastritis OT - helicobacter pylori OT - hematological indices OT - neutrophil-to-lymphocyte ratio OT - pediatric gastritis COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Jinnah Postgraduate Medical Centre issued approval ERC/2023. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/12/29 07:08 MHDA- 2025/12/29 07:09 PMCR- 2025/11/25 CRDT- 2025/12/29 05:14 PHST- 2025/11/24 00:00 [accepted] PHST- 2025/12/29 07:09 [medline] PHST- 2025/12/29 07:08 [pubmed] PHST- 2025/12/29 05:14 [entrez] PHST- 2025/11/25 00:00 [pmc-release] AID - 10.7759/cureus.97817 [doi] PST - epublish SO - Cureus. 2025 Nov 25;17(11):e97817. doi: 10.7759/cureus.97817. eCollection 2025 Nov. PMID- 41458526 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251229 LR - 20260926 IS - 2048-7177 (Print) IS - 2048-7177 (Electronic) IS - 2048-7177 (Linking) VI - 14 IP - 1 DP - 2026 Jan TI - The Breastfeeding Food Security Assessment Scale (BFSAS): Development and Validation Among Breastfeeding Women in Lebanon. PG - e71355 LID - 10.1002/fsn3.71355 [doi] LID - e71355 AB - Food insecurity significantly impacts health, particularly for breastfeeding mothers, who require adequate nutrition for maternal and child health. In Lebanon, economic crises have worsened food insecurity, affecting nearly half of the population. Crrent food insecurity assessment tools do not address the specific needs of breastfeeding women. This study aimed to develop and validate the Breastfeeding Food Security Assessment Scale (BFSAS), a context-specific tool for assessing food security among breastfeeding mothers in Lebanon, and to examine sociodemographic factors associated with food insecurity within this population. A cross-sectional survey was conducted from December 2023 to March 2024 among Lebanese mothers who had given birth between 2018 and 2023. Participants were recruited through social media and completed an online questionnaire covering sociodemographic, dietary, mental health, breastfeeding, and food security-related questions. Data analysis included exploratory and confirmatory factor analyses to validate the BFSAS structure and statistical tests to explore associations with the BFSAS scores. The study included 305 participants, with the BFSAS demonstrating excellent psychometric properties and a two-factor structure, "quality" and "quantity," with high internal consistency (Cronbach's alpha = 0.95). Approximately 23% of participants experienced food insecurity during breastfeeding. Older age and higher household income were associated with lower odds of food insecurity, while the number of children in the household increased the likelihood of food insecurity. The BFSAS is a valid, reliable, culturally adapted tool for assessing food insecurity among breastfeeding women in Lebanon. It facilitates targeted interventions to support breastfeeding mothers, especially in regions with lower socioeconomic status. CI - (c) 2025 The Author(s). Food Science & Nutrition published by Wiley Periodicals LLC. FAU - Fakih El Khoury, Cosette AU - Fakih El Khoury C AUID- ORCID: 0000-0001-6935-2758 AD - Institut National de Sante Publique d'Epidemiologie Clinique et de Toxicologie-Liban (INSPECT-LB) Beirut Lebanon. FAU - Kharma, Joelle Abi AU - Kharma JA AUID- ORCID: 0009-0009-9926-0905 AD - Department of Nutrition and Food Science, School of Arts and Sciences Lebanese American University Byblos Lebanon. FAU - Nicolas, Petra AU - Nicolas P AUID- ORCID: 0009-0001-5379-7223 AD - Department of Nutrition and Food Science, School of Arts and Sciences Lebanese American University Byblos Lebanon. FAU - Rizk, Rana AU - Rizk R AUID- ORCID: 0000-0002-8850-6502 AD - Department of Nutrition and Food Science, School of Arts and Sciences Lebanese American University Byblos Lebanon. FAU - Haddad, Chadia AU - Haddad C AUID- ORCID: 0000-0003-2413-2684 AD - Institut National de Sante Publique d'Epidemiologie Clinique et de Toxicologie-Liban (INSPECT-LB) Beirut Lebanon. AD - Research Department Psychiatric Hospital of the Cross Jal Eddib Lebanon. AD - Faculty of Public Health Lebanese University Fanar Lebanon. FAU - Sacre, Hala AU - Sacre H AUID- ORCID: 0000-0001-6547-6251 AD - Institut National de Sante Publique d'Epidemiologie Clinique et de Toxicologie-Liban (INSPECT-LB) Beirut Lebanon. FAU - Abdallah, Bahia AU - Abdallah B AUID- ORCID: 0000-0002-3979-8094 AD - Alice Ramez Chagoury School of Nursing, LAU-Lebanese American University Lebanese American University Byblos Lebanon. FAU - El Mikkawi, Hala AU - El Mikkawi H AD - Department of Nutrition and Food Science, School of Arts and Sciences Lebanese American University Beirut Lebanon. FAU - Karam, Joanne AU - Karam J AUID- ORCID: 0000-0003-2637-1347 AD - Institut National de Sante Publique d'Epidemiologie Clinique et de Toxicologie-Liban (INSPECT-LB) Beirut Lebanon. FAU - Salameh, Pascale AU - Salameh P AUID- ORCID: 0000-0002-4780-0772 AD - Institut National de Sante Publique d'Epidemiologie Clinique et de Toxicologie-Liban (INSPECT-LB) Beirut Lebanon. AD - Faculty of Pharmacy Lebanese University Hadat Lebanon. AD - Department of Primary Care and Population Health University of Nicosia Medical School Nicosia Cyprus. AD - Gilbert and Rose-Marie Chagoury School of Medicine Lebanese American University Beirut Lebanon. LA - eng PT - Journal Article DEP - 20251226 PL - United States TA - Food Sci Nutr JT - Food science & nutrition JID - 101605473 PMC - PMC12741885 OTO - NOTNLM OT - Lebanon OT - breast feeding OT - developing countries OT - food insecurity OT - food security OT - maternal nutrition OT - validation study COIS- The authors declare no conflicts of interest. EDAT- 2025/12/29 07:08 MHDA- 2025/12/29 07:09 PMCR- 2025/12/26 CRDT- 2025/12/29 05:12 PHST- 2025/06/29 00:00 [received] PHST- 2025/10/27 00:00 [revised] PHST- 2025/11/04 00:00 [accepted] PHST- 2025/12/29 07:09 [medline] PHST- 2025/12/29 07:08 [pubmed] PHST- 2025/12/29 05:12 [entrez] PHST- 2025/12/26 00:00 [pmc-release] AID - FSN371355 [pii] AID - 10.1002/fsn3.71355 [doi] PST - epublish SO - Food Sci Nutr. 2025 Dec 26;14(1):e71355. doi: 10.1002/fsn3.71355. eCollection 2026 Jan. PMID- 41458428 OWN - NLM STAT- MEDLINE DCOM- 20251229 LR - 20251231 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Development and validation of a predictive model for weight loss psychological distress in obese patients: a cross-sectional study. PG - 1700100 LID - 10.3389/fpubh.2025.1700100 [doi] LID - 1700100 AB - BACKGROUND: Obese patients are more likely to experience psychological distress symptoms, such as low self-esteem, anxiety and depression. Approximately 18-55% of obese patients will encounter problems such as abdominal distension, purple skin lines and facial acne due to changes in their body shape and appearance. Establishing a predictive model for psychological distress in obese patients during the weight loss process, early identification of high-risk groups, and the adoption of proactive intervention measures can help reduce the incidence of psychological distress. AIMS: Explore the risk factors for psychological distress among middle-aged and young obese patients, and construct and validate a risk prediction model for psychological distress. METHODS: The study was a cross-sectional survey study, From January to June in 2025, a total of 357 obese patients were selected from 22 tertiary hospitals in Jiangxi Province, China. The model was constructed by univariate and logistic regression analyses. They were divided into the group with significant psychological distress (K10 >/= 16 points) and the group without significant psychological distress (K10 < 16 points). R4.2.3 Statistical software was used to construct a risk prediction model for psychological distress in obese patients regarding weight loss. The discriminative ability of the model was evaluated by the receiver operating characteristic (ROC) curve, the accuracy of the predictive model was evaluated by the Hosmer-Lemeshow test and calibration curves, and the clinical utility was assessed using decision curve analysis (DCA). RESULTS: Two hundred fifty-five patients were in the training set and 102 were in the validation set. Through logistics regression analysis, the following seven predictive factors were obtained: age (youth), gender (female), history of chronic diseases, high BMI, weight loss method (diet and exercise for weight loss), perceived social support, and general self-efficacy. The area under the ROC curve of the model was 0.852 (95%CI, 0.806 ~ 0.897). The sensitivity and specificity were 0.804 and 0.729. The maximum Youden index was 0.520, and the best cut-off value was 0.396. The Hosmer-Lemeshow test showed that chi (2) = 4.560 and p = 0.803. The internal and external validation results showed that the area under the ROC curve was 0.858 and 0.833 respectively, and the Hosmer-Lemeshow test results showed that the chi (2) was 0.664 and 0.765, respectively. The decision curve analysis shows that obese patients have better clinical benefits. CONCLUSION: This study developed a predictive model for weight loss psychological distress in obese patients, which has strong predictive performance and has been verified by internal and external cohorts. It was helpful for the early detection of high-risk groups for weight loss psychological distress. CI - Copyright (c) 2025 Cheng, Liu, Li, Tang and Huang. FAU - Cheng, Zhiqiang AU - Cheng Z AD - Department of Health Management Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. FAU - Liu, Meiling AU - Liu M AD - Department of Health Management Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. FAU - Li, Xiaxin AU - Li X AD - Department of Nursing, The Affiliated Hospital of Jiangxi University of Chinese Medicine, Nanchang, Jiangxi, China. FAU - Tang, Jiazhen AU - Tang J AD - Department of Health Management Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. FAU - Huang, Caihong AU - Huang C AD - Department of Anesthesiology and Surgery, The First Affiliated Hospital of Gan Nan Medical University, Jiangxi, Ganzhou, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20251201 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Male MH - *Obesity/psychology MH - Middle Aged MH - Adult MH - *Weight Loss MH - *Psychological Distress MH - China MH - Risk Factors MH - Surveys and Questionnaires MH - *Stress, Psychological/epidemiology PMC - PMC12741267 OTO - NOTNLM OT - nursing care OT - obesity OT - predictive model OT - psychological distress OT - risk factors COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/29 07:08 MHDA- 2025/12/29 07:09 PMCR- 2025/12/01 CRDT- 2025/12/29 05:10 PHST- 2025/09/06 00:00 [received] PHST- 2025/11/11 00:00 [revised] PHST- 2025/11/12 00:00 [accepted] PHST- 2025/12/29 07:09 [medline] PHST- 2025/12/29 07:08 [pubmed] PHST- 2025/12/29 05:10 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1700100 [doi] PST - epublish SO - Front Public Health. 2025 Dec 1;13:1700100. doi: 10.3389/fpubh.2025.1700100. eCollection 2025. PMID- 41458372 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251229 LR - 20260926 IS - 2398-8835 (Electronic) IS - 2398-8835 (Linking) VI - 9 IP - 1 DP - 2026 Jan TI - Ultrasound Assessment of Diaphragmatic Function in Children With Cerebral Palsy: A Cross-Sectional Observational Case-Control Study. PG - e71644 LID - 10.1002/hsr2.71644 [doi] LID - e71644 AB - BACKGROUND AND AIMS: Children with cerebral palsy (CP) are vulnerable to respiratory infections and chronic airway inflammation, which leads to diminished respiratory function. This decline is exacerbated by muscle tone abnormalities and reduced strength, worsening as CP progresses. Traditional lung function tests are often impractical for those with severe cognitive and motor impairments. Diaphragm evaluation through ultrasound imaging emerges as a non-invasive, easy-to-apply technique for assessing respiratory function in CP children. This study aimed to evaluate diaphragm function in CP and typically developing (TD) children using ultrasound, focusing on diaphragm thickness and excursion parameters. The study also explored factors influencing respiratory function, particularly the number of lower respiratory tract infections (LRTI). METHODS: The study included 10 CP (11.2; range 4-17 years) and 12 TD children (8.9 years; range 4-13 years). M-mode ultrasound assessed diaphragm thickness, thickening fraction (TF), and inspiratory slope (IS). Additionally, data on demographics, anthropometrics, medical history, and physical examination were collected. RESULTS: The intra-operator reliability for diaphragm ultrasound measurements showed good to excellent consistency (over 0.86). Significant differences were found between CP and TD children; CP children exhibited lower excursion and IS, with a non-significant trend towards reduced diaphragm thickness. LTRI were associated to decreased excursion and IS, and increased TF in CP children. CONCLUSIONS: Diaphragmatic ultrasound is a non-invasive, reproducible tool for assessing respiratory function in both CP and TD children, even in cases of severe cognitive and motor impairment. It effectively identifies diaphragm dysfunction associated with LRTI. CI - (c) 2025 The Author(s). Health Science Reports published by Wiley Periodicals LLC. FAU - Casellas-Vidal, Dolors AU - Casellas-Vidal D AUID- ORCID: 0000-0001-9560-6758 AD - Servei de Pediatria Hospital Universitari Doctor Josep Trueta Girona Spain. AD - Neurodevelopmental Group (Girona Biomedical Research Institute)-IDIBGI, Institute of Health Assistance (IAS) Parc Hospitalari Marti i Julia Girona Spain. FAU - Osiniri, Ines AU - Osiniri I AD - Servei de Pediatria Clinica Bofill Girona Spain. FAU - Font-Llado, Raquel AU - Font-Llado R AUID- ORCID: 0000-0002-2282-2756 AD - University School of Health and Sport (EUSES) University of Girona Girona Spain. AD - Research Group of Culture and Education, Institute of Educational Research University of Girona Girona Spain. FAU - Camos-Carreras, Maria AU - Camos-Carreras M AD - Servei de Pediatria Hospital Universitari Doctor Josep Trueta Girona Spain. AD - Neurodevelopmental Group (Girona Biomedical Research Institute)-IDIBGI, Institute of Health Assistance (IAS) Parc Hospitalari Marti i Julia Girona Spain. FAU - Ruiz-Eizmendi, Aintzane AU - Ruiz-Eizmendi A AD - Servei de Rehabilitacio Hospital Universitari Doctor Josep Trueta Girona Spain. FAU - Serrano-Ferrer, Juan AU - Serrano-Ferrer J AD - University School of Health and Sport (EUSES) University of Girona Girona Spain. FAU - Casellas, Joaquim AU - Casellas J AUID- ORCID: 0000-0002-4982-3556 AD - Departament de Ciencia Animal i dels Aliments Universitat Autonoma de Barcelona Bellaterra Spain. FAU - Lopez-Bermejo, Abel AU - Lopez-Bermejo A AUID- ORCID: 0000-0002-5828-8911 AD - Servei de Pediatria Hospital Universitari Doctor Josep Trueta Girona Spain. AD - Pediatric Endocrinology Group Girona Biomedical Research Institute (IDIBGI) Salt Spain. AD - Department of Medical Sciences, School of Medicine University of Girona Girona Spain. FAU - Prats-Puig, Anna AU - Prats-Puig A AUID- ORCID: 0000-0002-5253-3808 AD - University School of Health and Sport (EUSES) University of Girona Girona Spain. AD - Research Group Health and Health Care, Nursing Department University of Girona Girona Spain. LA - eng PT - Journal Article DEP - 20251225 PL - United States TA - Health Sci Rep JT - Health science reports JID - 101728855 PMC - PMC12741228 OTO - NOTNLM OT - cerebral palsy OT - diaphragm ultrasound OT - lower respiratory tract infection OT - respiratory function COIS- The authors declare no conflicts of interest. EDAT- 2025/12/29 07:08 MHDA- 2025/12/29 07:09 PMCR- 2025/12/25 CRDT- 2025/12/29 05:10 PHST- 2025/01/20 00:00 [received] PHST- 2025/05/20 00:00 [revised] PHST- 2025/12/02 00:00 [accepted] PHST- 2025/12/29 07:09 [medline] PHST- 2025/12/29 07:08 [pubmed] PHST- 2025/12/29 05:10 [entrez] PHST- 2025/12/25 00:00 [pmc-release] AID - HSR271644 [pii] AID - 10.1002/hsr2.71644 [doi] PST - epublish SO - Health Sci Rep. 2025 Dec 25;9(1):e71644. doi: 10.1002/hsr2.71644. eCollection 2026 Jan. PMID- 41457433 OWN - NLM STAT- MEDLINE DCOM- 20251229 LR - 20260619 IS - 1557-0657 (Electronic) IS - 1049-8931 (Print) IS - 1049-8931 (Linking) VI - 34 IP - 4 DP - 2025 Dec TI - Translation and Validation of the Arabic Version of the Revised Restrictive Behaviours Scale Among Iraqi Children With Autism Spectrum Disorder: A Suggestion for Model Modification. PG - e70048 LID - 10.1002/mpr.70048 [doi] LID - e70048 AB - OBJECTIVES: Comprehensive scales should be used to better understand the patterns of restrictive and repetitive behaviours in children with autism spectrum disorder in middle and lower-income countries. This study aimed to validate an Arabic translation of the revised Repetitive Behaviours Scale. METHODS: Parents of 258 children were interviewed in a cross-sectional study conducted at Al-Subtain Academy from December 1, 2023, to August 1, 2024. The R Language and Environment for Statistical Programing v4.4.2 was utilised for statistical analysis. RESULTS: Following confirmatory factor analysis, the 6-factor solution was selected for further testing based on more favourable fitness indices and the 2-factor solution was selected based on an acceptable RMSEA of 0.064 and evidence of cross-cultural validity from previous validations. The 2-factor solution demonstrated better subscales' reliability, with composite coefficients of 0.801 and 0.908, and corrected item-total correlations that are more consistent with the theoretical framework for the scale. A modification for this model was suggested based on item performance and demonstrated a marginal improvement in the CFI and TLI indices. CONCLUSION: The Arabic revised repetitive behaviours scale demonstrates a valid and reliable structure, aligning with the conceptual classification of repetitive and restrictive behaviours into repetitive sensory-motor behaviours and insistence on sameness. CI - (c) 2025 The Author(s). International Journal of Methods in Psychiatric Research published by John Wiley & Sons Ltd. FAU - Hussein Al-Sultan, Ruaa Raoof AU - Hussein Al-Sultan RR AD - Al-Subtain Academy for Autism and Neurodevelopmental Disorders, Karbala, Iraq. FAU - Jasim, Shatha Mohammed AU - Jasim SM AD - Al-Subtain Academy for Autism and Neurodevelopmental Disorders, Karbala, Iraq. AD - Al-Subtain University of Medical Sciences, International Branch of Tehran University for Medical Sciences, Karbala, Iraq. FAU - Lami, Faris AU - Lami F AD - Al-Subtain University of Medical Sciences, International Branch of Tehran University for Medical Sciences, Karbala, Iraq. AD - Department of Community Medicine, College of Medicine, University of Baghdad, Baghdad, Iraq. FAU - Jaber, Osamah Abbas AU - Jaber OA AD - Al-Subtain Academy for Autism and Neurodevelopmental Disorders, Karbala, Iraq. AD - Al-Subtain University of Medical Sciences, International Branch of Tehran University for Medical Sciences, Karbala, Iraq. FAU - Nayeri, Nahid Dehghan AU - Nayeri ND AD - Al-Subtain University of Medical Sciences, International Branch of Tehran University for Medical Sciences, Karbala, Iraq. AD - Nursing and Midwifery Care Research Centre, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran. FAU - Sabet, Mahdi Shafiee AU - Sabet MS AD - Al-Subtain University of Medical Sciences, International Branch of Tehran University for Medical Sciences, Karbala, Iraq. AD - Department of Family Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. FAU - Al-Gburi, Ghaith AU - Al-Gburi G AUID- ORCID: 0000-0001-7427-8310 AD - Al-Subtain University of Medical Sciences, International Branch of Tehran University for Medical Sciences, Karbala, Iraq. AD - School of Bioscience, University of Birmingham, Birmingham, UK. LA - eng GR - Al-Subtain University of Medical Sciences/ GR - Al-Subtain Academy for Autism and Neurodevelopmental Disorders/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study PL - United States TA - Int J Methods Psychiatr Res JT - International journal of methods in psychiatric research JID - 9111433 SB - IM MH - Humans MH - *Autism Spectrum Disorder/diagnosis/physiopathology MH - Male MH - Female MH - Child MH - *Psychometrics/standards/instrumentation MH - Reproducibility of Results MH - Cross-Sectional Studies MH - Iraq MH - *Psychiatric Status Rating Scales/standards MH - *Stereotyped Behavior MH - Child, Preschool PMC - PMC12745494 OTO - NOTNLM OT - autism OT - factor analysis OT - repetitive and restrictive behaviours OT - translation OT - validation COIS- The authors declare no conflicts of Interest. EDAT- 2025/12/29 07:08 MHDA- 2025/12/29 07:09 PMCR- 2025/12/28 CRDT- 2025/12/29 00:52 PHST- 2025/08/23 00:00 [revised] PHST- 2025/03/29 00:00 [received] PHST- 2025/11/10 00:00 [accepted] PHST- 2025/12/29 07:09 [medline] PHST- 2025/12/29 07:08 [pubmed] PHST- 2025/12/29 00:52 [entrez] PHST- 2025/12/28 00:00 [pmc-release] AID - MPR70048 [pii] AID - 10.1002/mpr.70048 [doi] PST - ppublish SO - Int J Methods Psychiatr Res. 2025 Dec;34(4):e70048. doi: 10.1002/mpr.70048. PMID- 41457222 OWN - NLM STAT- MEDLINE DCOM- 20260207 LR - 20260604 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 26 IP - 1 DP - 2025 Dec 28 TI - The association between accelerometer-measured physical activity and symptoms of depression and anxiety in children and adolescents: a systematic review and meta-analysis. PG - 96 LID - 10.1186/s12887-025-06420-y [doi] LID - 96 AB - BACKGROUND: Physical activity (PA) is associated with symptoms of depression and anxiety in children and adolescents. Using accelerometers to measure PA can provide more accurate and detailed data to investigate this relationship. However, no study has systematically reviewed and pooled the effects of accelerometer-measured PA on mental health. Therefore, this meta-analysis examined the association between accelerometer-measured PA and symptoms of depression and anxiety in children and adolescents and determined whether the strength of this relationship varied by accelerometery methodology. METHODS: A systematic review conducted up to May 2025 using the following databases: Medline, PsycINFO, Embase, Web of Science, and SPORTDiscus, following the PRISMA guidelines, and using terms relating to children, PA, depression/anxiety and observational design. Meta-analyses were performed separately for 12 studies with continuous outcomes (Partial r) and 7 studies with binary outcomes (Odds Ratio). Subgroup analysis tested the moderating effects of accelerometer data collection and processing methods (e.g., epoch length, wear location, valid days, valid hours). RESULTS: Thirty studies met the inclusion criteria (n = 15 cross-sectional, n = 15 prospective) including 40,334 youth aged 5-18 years. There was a small negative association of moderate-to-vigorous physical activity (MVPA) with depression (partial r = -0.17, 95%CI [-0.28, -0.06], p < 0.001) and anxiety (partial r = -0.21, 95%CI [-0.34, -0.09], p < 0.001). Total physical activity (TPA) (OR = 0.98, 95%CI [0.96,1.00], p = 0.05) and light intensity PA (OR = 0.95, 95%CI [0.92,0.98], p < 0.001) were associated with reduced risk of depression. The association between MVPA and depression appeared to vary by epoch length ( 15 s partial r = -0.08, 95% [-0.19, 0.03]; difference p = 0.02). Sensitivity and publication bias analyses supported the overall robustness and reliability of the associations between PA and depression or anxiety. CONCLUSIONS: This review highlights that while PA was associated with reduced depression and anxiety in youth, substantial methodological heterogeneity, particularly in accelerometer protocols, may influence effect sizes. Improved and standardised accelerometry methodologies and developed innovative PA metrics are needed to better assess these relationships. TRIAL REGISTRATION: The protocol for the present review was registered on PROSPERO (CRD42022320410) on 23rd March 2022. KEY POINTS: * This systematic review included 30 studies involving 40,334 children and adolescents aged 5-18 years and revealed substantial variability in accelerometer data collection and processing methods across studies, including 11 different device models, 4 wear locations, 6 epoch lengths, 4 intensity thresholds units, 5 valid day definitions, and 7 non-wear criteria, as well as 17 questionnaires used to assess depression and anxiety. * Meta-analysis results showed that moderate-to-vigorous, total, and light physical activity were associated with reduced depression and anxiety in youth, while epoch length and accelerometer wear location may affect the magnitude of this relationship. The findings remained consistent across sensitivity analyses, and no evidence of publication bias was detected. * Of the 30 studies assessed for risk of bias, 2 were rated as good quality, 22 as fair quality, and 6 as poor quality. The main quality problems were the lack of sample size justification, or insufficient reporting of uniform selection criteria. CI - (c) 2025. The Author(s). FAU - Wang, Lin AU - Wang L AD - Faculty of Health and Life Sciences, Public Health and Sport Sciences, University of Exeter, Room 33 Haighton Library, Heavitree Road, St Luke's Campus, Exeter, Devon, EX1 2LU, UK. lw679@exeter.ac.uk. FAU - Barker, Alan R AU - Barker AR AD - Faculty of Health and Life Sciences, Children's Health and Exercise Research Centre, Public Health and Sport Sciences, University of Exeter, Exeter, UK. FAU - Metcalf, Brad AU - Metcalf B AD - Faculty of Health and Life Sciences, Public Health and Sport Sciences, University of Exeter, Room 33 Haighton Library, Heavitree Road, St Luke's Campus, Exeter, Devon, EX1 2LU, UK. FAU - Liu, Yihao AU - Liu Y AD - Department of Social Psychiatry, West China Hospital, Sichuan University, Sichuan, 610041, Chengdu, China. FAU - Hillsdon, Melvyn AU - Hillsdon M AD - Faculty of Health and Life Sciences, Public Health and Sport Sciences, University of Exeter, Room 33 Haighton Library, Heavitree Road, St Luke's Campus, Exeter, Devon, EX1 2LU, UK. FAU - Price, Lisa AU - Price L AD - Faculty of Health and Life Sciences, Public Health and Sport Sciences, University of Exeter, Room 33 Haighton Library, Heavitree Road, St Luke's Campus, Exeter, Devon, EX1 2LU, UK. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20251228 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Humans MH - Child MH - Adolescent MH - *Accelerometry MH - *Exercise/psychology MH - *Depression MH - *Anxiety MH - Child, Preschool PMC - PMC12882467 OTO - NOTNLM OT - Accelerometery methodologies OT - Activity behaviours OT - Mental health OT - Young people COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/29 00:24 MHDA- 2026/02/07 06:33 PMCR- 2025/12/28 CRDT- 2025/12/28 23:13 PHST- 2025/08/07 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2026/02/07 06:33 [medline] PHST- 2025/12/29 00:24 [pubmed] PHST- 2025/12/28 23:13 [entrez] PHST- 2025/12/28 00:00 [pmc-release] AID - 10.1186/s12887-025-06420-y [pii] AID - 6420 [pii] AID - 10.1186/s12887-025-06420-y [doi] PST - epublish SO - BMC Pediatr. 2025 Dec 28;26(1):96. doi: 10.1186/s12887-025-06420-y. PMID- 41456969 OWN - NLM STAT- MEDLINE DCOM- 20260211 LR - 20260518 IS - 1871-403X (Print) IS - 1871-403X (Linking) VI - 20 IP - 1 DP - 2026 Jan-Feb TI - Children's experience of screening and evaluation for MASLD in overweight and obesity. PG - 76-79 LID - S1871-403X(25)00155-3 [pii] LID - 10.1016/j.orcp.2025.12.010 [doi] AB - OBJECTIVE: This study evaluates self-reported discomfort in children undergoing screening and evaluation for Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) that includes blood sampling and vibration-controlled transient elastography (VCTE) or shear-wave elastography (SWE). METHODS: In this cross-sectional multicenter cohort study, children with overweight or obesity, referred for MASLD evaluation after elevated ALT, were included. Children subsequently underwent anthropometric measurements, blood sampling, VCTE, and SWE during an outpatient visit. Discomfort was assessed using the validated "Discomfort in Research with Children" (DISCO-RC) questionnaire on a 5-point Likert scale. RESULTS: 118 children (mean age 13 years) were included. Discomfort related to MASLD screening was low, with median domain scores of 1-2 before the MASLD evaluation visit and 1 after. Prior to the visit, 76-82 % reported "no" to "slight" discomfort (score 1-2) across domains; during the visit, this was 91-95 %. Median procedural discomfort per domain was 1 for both VCTE and SWE, though cumulative discomfort (6 domains) was greater for VCTE than SWE (8 [IQR 6,9] versus 7 [IQR 6,8] p < 0.001). CONCLUSIONS: Screening and subsequent evaluation for MASLD, including VCTE or SWE for liver fibrosis assessment, is associated with minimal discomfort and is highly acceptable to children, supporting this screening strategy in pediatric clinical practice. CI - Copyright (c) 2025 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved. FAU - Stroes, Anne-Sophie R AU - Stroes AR AD - Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam, the Netherlands; Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands. Electronic address: a.r.stroes@amsterdamumc.nl. FAU - Draijer, Laura AU - Draijer L AD - Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands. FAU - van Oers, Hedy A AU - van Oers HA AD - Department of Child and Adolescent Psychiatry and Psychosocial Care, Emma Children's Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands. FAU - Chegary, Malika AU - Chegary M AD - Department of Pediatrics, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands. FAU - Kreier, Felix AU - Kreier F AD - Department of Pediatrics, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands. FAU - van Os, Erim AU - van Os E AD - Department of Pediatrics, Rode Kruis Ziekenhuis, Beverwijk, the Netherlands. FAU - Goede, Joery AU - Goede J AD - Department of Pediatrics, Spaarne Gasthuis, Haarlem, the Netherlands. FAU - Boonstra, Venje AU - Boonstra V AD - Department of Pediatrics, BovenIJ Ziekenhuis, Amsterdam, the Netherlands. FAU - Westerbeek, Ilse AU - Westerbeek I AD - Department of Pediatrics, Amstelland Ziekenhuis, Amsterdam, the Netherlands. FAU - Bouma, Saskia AU - Bouma S AD - De Kinderartsenpraktijk, Amsterdam, the Netherlands. FAU - Kusters, D Meeike AU - Kusters DM AD - Department of Pediatrics, Onze Lieve Vrouwe Gasthuis, Amsterdam, the Netherlands. FAU - Roelants, Roosje AU - Roelants R AD - Department of Pediatrics, Flevoziekenhuis, Almere, the Netherlands. FAU - Beuers, Ulrich AU - Beuers U AD - Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam, the Netherlands; Department of Gastroenterology and Hepatology, Amsterdam University Medical Centre, University of Amsterdam, Amsterdam, the Netherlands. FAU - Holleboom, Adriaan G AU - Holleboom AG AD - Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam, the Netherlands; Department of Vascular Medicine, Amsterdam University Medical Centre, Amsterdam, the Netherlands. FAU - Benninga, Marc A AU - Benninga MA AD - Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam, the Netherlands; Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands. FAU - Koot, Bart G P AU - Koot BGP AD - Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, location University of Amsterdam, Amsterdam, the Netherlands; Amsterdam Gastroenterology Endocrinology Metabolism Research Institute, Amsterdam, the Netherlands; Amsterdam Reproduction and Development Research Institute, Amsterdam, the Netherlands. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20251227 PL - Netherlands TA - Obes Res Clin Pract JT - Obesity research & clinical practice JID - 101303911 SB - IM MH - Humans MH - Female MH - Male MH - Cross-Sectional Studies MH - Child MH - Adolescent MH - *Pediatric Obesity/complications MH - Elasticity Imaging Techniques MH - *Mass Screening MH - *Overweight/complications MH - *Fatty Liver/diagnosis/etiology MH - Self Report MH - Cohort Studies OTO - NOTNLM OT - Children OT - Discomfort Assessment OT - Metabolic dysfunction-Associated Steatotic Liver Disease OT - Patient Experience OT - Patient-Reported Outcomes COIS- Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Anne-Sophie Stroes reports financial support was provided by Forwis(h)dom foundation. Anne-Sophie Stroes reports financial support was provided by Virtutis Opus foundation. Anne-Sophie Stroes reports financial support was provided by Jean Louis Bernardi foundation. Anne-Sophie Stroes reports financial support was provided by Louise Vehmeijer foundation. Bart Koot reports a relationship with Boehringer Ingelheim and Inventiva that includes: consulting or advisory. Ulrich Beuers reports a relationship with Abacus, Amgen, Behring, Ipsen, Mirum, Ono that includes: consulting or advisory. Ulrich Beuers reports a relationship with Abacus, Amgen, GSK, Ipsen that includes: speaking and lecture fees. Adriaan Holleboom reports a relationship with Novo Nordisk, Inventiva and Echosens that includes: consulting or advisory. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/29 00:24 MHDA- 2026/02/12 00:47 CRDT- 2025/12/28 21:56 PHST- 2025/12/12 00:00 [received] PHST- 2025/12/20 00:00 [accepted] PHST- 2026/02/12 00:47 [medline] PHST- 2025/12/29 00:24 [pubmed] PHST- 2025/12/28 21:56 [entrez] AID - S1871-403X(25)00155-3 [pii] AID - 10.1016/j.orcp.2025.12.010 [doi] PST - ppublish SO - Obes Res Clin Pract. 2026 Jan-Feb;20(1):76-79. doi: 10.1016/j.orcp.2025.12.010. Epub 2025 Dec 27. PMID- 41456246 OWN - NLM STAT- MEDLINE DCOM- 20260916 LR - 20261008 IS - 1573-3572 (Electronic) IS - 1068-9583 (Linking) VI - 33 IP - 3 DP - 2026 Sep TI - Understanding Family Burden Associated with Pediatric Food Allergy: Contributions of Child Neophobia and Maternal Personality Traits. PG - 492-501 LID - 10.1007/s10880-025-10118-9 [doi] AB - Food allergy (FA) is a chronic condition that can markedly affect family quality of life (QoL). Children's food neophobia (FN) may increase dietary management difficulties and parental stress, while maternal personality traits can shape family adjustment. This study examined the associations between maternal neuroticism, child FN, and the perceived impact of FA on family QoL, also considering the influence of child age. Sixty-three Portuguese mothers of children with physician-diagnosed FA completed a sociodemographic and clinical questionnaire and validated self-report measures: the Food Neophobia Scale for Children, the NEO Five-Factor Inventory, and the Food Allergy Quality of Life Questionnaire - Parent Form (FAQLQ-PF). Preliminary correlations guided predictor selection, followed by multiple linear regression models (enter method) for each FAQLQ-PF subscale: Emotional Impact, Food Anxiety, and Dietary/Social Limitations. Higher maternal neuroticism, greater child FN, and older child age were significantly associated with a greater perceived impact of FA on family QoL. The models explained 35.5% of the variance in Emotional Impact, F (3, 58) = 12.19, p < .001; 35.5% in Food Anxiety, F (3, 58) = 12.19, p < .001; and 32.9% in Dietary/Social Limitations, F (3, 56) = 10.66, p < .001. These findings underscore the need to integrate psychological screening and tailored psychosocial support into allergy care, addressing both maternal emotional traits and child eating behaviors to promote adaptive family functioning. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Domingues, Mariana AU - Domingues M AD - CINTESIS.UPT@RISE-HEALTH, Universidade Portucalense, Porto, Portugal. marianavidomingues@gmail.com. FAU - Monteiro, Andreia AU - Monteiro A AD - Department of Psychology and Education, Universidade Portucalense, Porto, Portugal. FAU - Conde, Ana AU - Conde A AD - CINTESIS.UPT@RISE-HEALTH, Universidade Portucalense, Porto, Portugal. anac@upt.pt. FAU - Coimbra, Alice AU - Coimbra A AD - Allergy and Clinical Immunology Department, ULS Sao Joao, Porto, Portugal. FAU - Araujo, Maria AU - Araujo M AD - Department of Psychology and Education, Universidade Portucalense, Porto, Portugal. maraujo@upt.pt. LA - eng PT - Journal Article DEP - 20251228 PL - United States TA - J Clin Psychol Med Settings JT - Journal of clinical psychology in medical settings JID - 9435680 SB - IM MH - Humans MH - Female MH - Child MH - *Food Hypersensitivity/psychology MH - *Mothers/psychology MH - Adult MH - *Neuroticism MH - *Quality of Life/psychology MH - Male MH - Child, Preschool MH - Portugal MH - *Personality MH - *Cost of Illness MH - Adolescent MH - Surveys and Questionnaires OTO - NOTNLM OT - Chronic illness adaptation OT - Family impact OT - Food allergy OT - Food neophobia OT - Maternal personality COIS- Declarations. Conflict of interest: The authors declare no competing interests. EDAT- 2025/12/28 14:53 MHDA- 2026/09/16 17:36 CRDT- 2025/12/28 11:04 PHST- 2025/07/11 00:00 [received] PHST- 2025/12/10 00:00 [accepted] PHST- 2026/09/16 17:36 [medline] PHST- 2025/12/28 14:53 [pubmed] PHST- 2025/12/28 11:04 [entrez] AID - 10.1007/s10880-025-10118-9 [pii] AID - 10.1007/s10880-025-10118-9 [doi] PST - ppublish SO - J Clin Psychol Med Settings. 2026 Sep;33(3):492-501. doi: 10.1007/s10880-025-10118-9. Epub 2025 Dec 28. PMID- 41455930 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2025 Dec 27 TI - Maternal Endocrine and Metabolic Health and Outcomes (MEMO): a prospective cohort study of gestational diabetes mellitus and subclinical hypothyroidism in China. PG - 147 LID - 10.1186/s12884-025-08294-5 [doi] LID - 147 AB - BACKGROUND: In recent years, more and more evidence has confirmed the "Developmental Origins of Health and Disease (DOHaD)" hypothesis, which states that adverse environments in early life can increase the risk of long-term metabolic diseases such as obesity and diabetes. Gestational diabetes mellitus (GDM) and subclinical hypothyroidism (SCH) during pregnancy are the most common endocrine diseases, which directly interfere with the intrauterine development environment of the fetus and thus are ideal research entry points for validating and extending the DOHaD theory. OBJECTIVE: This study aims to deeply explore the early impact of maternal endocrine disorders during pregnancy (with a focus on GDM and SCH) on the healthy development of the fetus, using key indicators such as birth weight as measures of early health outcomes. The research objectives include: 1) To Identify potential biomarkers that can be used for early prediction of GDM and SCH; 2) To observe the extent to which GDM and SCH affect the pregnancy outcome. METHODS: This will be a prospective cohort study involving 300 pregnant women. In addition to collecting general demographic information and clinical data of pregnant women, we also collect peripheral blood, urine, and fecal samples from pregnant women during the early, middle, and late stages of pregnancy. We also collect placental and umbilical cord blood samples during delivery. We conduct multi-omics analysis on the samples to comprehensively screen for differentially expressed molecules related to gestational endocrine diseases (GDM and SCH) and adverse outcomes. The main evaluation indicators are the birth weight of the offspring, including low birth weight, macrosomia, small for gestational age, and large for gestational age. The secondary outcome indicators include the following: 1) neonatal-related outcomes that include intrauterine growth restriction (IUGR), intrauterine fetal death (IUFD), preterm birth, low Apgar score, admission to the neonatal intensive care unit (NICU); and 2) maternal pregnancy outcomes that include gestational hypertension, preeclampsia, eclampsia, anemia, spontaneous abortion, type of delivery (vaginal, assisted vaginal delivery or cesarean section) and other complications. CONCLUSIONS: This study aims to establish a prospective Chinese pregnant cohort to investigate the effects of GDM and SCH on pregnancy outcomes. On this basis, this study will utilize multi-time-point collected biological samples and combine multi-omics technologies to identify high-risk phenotypic characteristics related to GDM and SCH, with the aim of achieving early identification, and hopefully, intervention in the future, thereby reducing adverse pregnancy outcomes and the risk of long-term chronic diseases in the offspring. TRIAL REGISTRATION: ClinicalTrials.gov ID: NCT05952739. Study Registration Dates: July 19, 2023. FAU - Zeng, Yuan AU - Zeng Y AD - Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. FAU - Yu, Jie AU - Yu J AD - Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. FAU - Ren, Yaolin AU - Ren Y AD - Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. FAU - Ren, Jing AU - Ren J AD - Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. FAU - Chen, Haiyan AU - Chen H AD - Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. FAU - Zhang, Qian AU - Zhang Q AD - Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. zhangqian6088@pumch.cn. FAU - Xiao, Xinhua AU - Xiao X AD - Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China. xiaoxh2014@vip.163.com. LA - eng SI - ClinicalTrials.gov/NCT05952739 GR - (Category C, UBJ06088)/Peking Union Medical College Hospital Talent Cultivation Program/ GR - (No. 82170854, 81870579, 81870545)/National Natural Science Foundation of China/ GR - (7202163)/Beijing Natural Science Foundation/ GR - (Z201100005520011),/Beijing Municipal Science & Technology Commission/ GR - (2022-PUMCH-C-019)/National High Level Hospital Clinical Research Funding/ GR - (CIFMS2021-1-I2M-002)/CAMS Innovation Fund for Medical Sciences/ GR - (2023-PT320-10)/the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences/ GR - (APL24100310010302079)/the Fundamental Research Funds for the Central Universities/ PT - Journal Article DEP - 20251227 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Diabetes, Gestational/epidemiology/diagnosis MH - *Hypothyroidism/epidemiology/diagnosis MH - China/epidemiology MH - Prospective Studies MH - Pregnancy Outcome MH - Biomarkers/blood/urine MH - Infant, Newborn MH - Adult MH - Birth Weight MH - Developmental Origins of Health and Disease MH - *Pregnancy Complications/epidemiology PMC - PMC12888118 OTO - NOTNLM OT - Biomarkers OT - Cohort study OT - Gestational diabetes mellitus (GDM) OT - Metabolic health OT - Pregnancy outcomes OT - Risk factors OT - Subclinical hypothyroidism (SCH) COIS- Declarations. Ethics approval and consent to participate: This clinical research protocol was approved by the Ethics Committee of Peking Union Medical College Hospital (I-23PJ162). This study adhered to the Declaration of Helsinki. Informed consent for study participation will be obtained through a signed written informed consent form. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/28 01:36 MHDA- 2026/06/27 00:58 PMCR- 2025/12/27 CRDT- 2025/12/27 23:55 PHST- 2025/08/04 00:00 [received] PHST- 2025/09/26 00:00 [accepted] PHST- 2026/06/27 00:58 [medline] PHST- 2025/12/28 01:36 [pubmed] PHST- 2025/12/27 23:55 [entrez] PHST- 2025/12/27 00:00 [pmc-release] AID - 10.1186/s12884-025-08294-5 [pii] AID - 8294 [pii] AID - 10.1186/s12884-025-08294-5 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2025 Dec 27;26(1):147. doi: 10.1186/s12884-025-08294-5. PMID- 41455634 OWN - NLM STAT- MEDLINE DCOM- 20260214 LR - 20260214 IS - 1769-664X (Electronic) IS - 0929-693X (Linking) VI - 33 IP - 1 DP - 2026 Jan TI - Feasibility and acceptability of a new adapted physical activity program for children with chronic disease: a pilot study. PG - 55-60 LID - S0929-693X(25)00257-X [pii] LID - 10.1016/j.arcped.2025.12.001 [doi] AB - BACKGROUND: Increasing physical activity and reducing sedentary time in children and adolescents with chronic illness is a critical challenge. Despite several studies supporting the benefits of exercise programmes for improving physical and psychological health, such programmes remain relatively uncommon in the care of children and adolescents with chronic disease. OBJECTIVES: To evaluate the feasibility and acceptability of integrating an Adapted Physical Activity (APA) programme into routine paediatric outpatient care, aiming to bridge the gap between strong scientific findings and everyday clinical practice of paediatricians. METHODS AND SETTING: Adolescents with congenital heart disease, obesity, or sickle cell anemia voluntarily participated in a supervised 2-month APA program in the pediatric department of Nantes University Hospital. Feasibility and acceptability were assessed using study-specific questionnaires. The efficacy and benefits of the APA program were evaluated with performance measures including changes in aerobic fitness through VO2 measurements, muscle mass and fat mass, the five-times sit-to-stand test and six-minute walk test, and pediatric quality of life scores. RESULTS: Among the 17 included adolescents (11-17 years old), 13 (76 %) completed the 2-month APA program. The mean attendance was 79.4 % (18/24 sessions); 91 % enjoyed this activity; and 83 % of parents reported that this program was helpful for their adolescent. Following the intervention, patients experienced no adverse effects, reported a 7 % improvement in quality of life (p = 0.02), and demonstrated enhanced functional motor activities, including increased aerobic exercise capacity and functional performance on the six-minute walking test (+15.3 %; p < 0.01). CONCLUSION: These preliminary findings suggest that APA interventions are highly implementable in children with chronic diseases. We report a significant benefit on the quality of life and physical performance. Larger APA programs implementation is needed to confirm, with a high level of evidence, the importance of integration of APA programmes into routine paediatric care. CI - Copyright (c) 2025 The Author(s). Published by Elsevier Masson SAS.. All rights reserved. FAU - Landois, Martin AU - Landois M AD - CIC 1413, Epidemiologie clinique INSERM 1043-CHU Hopital Mere Enfant, CHU Nantes F-44000 Nantes, France; UFR Sciences et Techniques des Activites Physiques et Sportives, Nantes Universite, France. FAU - Hauet, Quentin AU - Hauet Q AD - Service de cardiologie pediatrique medico chirurgicale, Hopital Mere Enfant CHU NANTES, France. FAU - Couec, Marie-Laure AU - Couec ML AD - Service d'onco-hematologie, Hopital Mere Enfant CHU NANTES, France. FAU - Lacroix, Sylvie AU - Lacroix S AD - Hopital de jour des adolescents, Hopital Mere Enfant CHU NANTES, France. FAU - Menut, Vanessa AU - Menut V AD - Service de pediatrie generale, Hopital Mere Enfant CHU NANTES, France. FAU - Drouard, Anne Chauvire AU - Drouard AC AD - CIC 1413, Epidemiologie clinique INSERM 1043-CHU Hopital Mere Enfant, CHU Nantes F-44000 Nantes, France. FAU - Guen, Christele Gras-Le AU - Guen CG AD - CIC 1413, Epidemiologie clinique INSERM 1043-CHU Hopital Mere Enfant, CHU Nantes F-44000 Nantes, France; Service de pediatrie generale, Hopital Mere Enfant CHU NANTES, France. FAU - Deschamps, Thibault AU - Deschamps T AD - UFR Sciences et Techniques des Activites Physiques et Sportives, Nantes Universite, France; Nantes Universite, CHU Nantes, Motricite - Interactions - Performance, MIP, UR 4334, F-44000 Nantes, France. Electronic address: thibault.deschamps@univ-nantes.fr. LA - eng PT - Journal Article DEP - 20251227 PL - France TA - Arch Pediatr JT - Archives de pediatrie : organe officiel de la Societe francaise de pediatrie JID - 9421356 SB - IM MH - Humans MH - Adolescent MH - Pilot Projects MH - Child MH - Feasibility Studies MH - Male MH - Female MH - Chronic Disease/therapy MH - *Exercise MH - Quality of Life MH - *Exercise Therapy/methods MH - Anemia, Sickle Cell/therapy OTO - NOTNLM OT - Congenital cardiopathy OT - Obesity OT - Physical health OT - Quality of live OT - Sickle cell disease COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2025/12/28 01:36 MHDA- 2026/02/15 00:31 CRDT- 2025/12/27 21:56 PHST- 2025/06/24 00:00 [received] PHST- 2025/11/26 00:00 [revised] PHST- 2025/12/04 00:00 [accepted] PHST- 2026/02/15 00:31 [medline] PHST- 2025/12/28 01:36 [pubmed] PHST- 2025/12/27 21:56 [entrez] AID - S0929-693X(25)00257-X [pii] AID - 10.1016/j.arcped.2025.12.001 [doi] PST - ppublish SO - Arch Pediatr. 2026 Jan;33(1):55-60. doi: 10.1016/j.arcped.2025.12.001. Epub 2025 Dec 27. PMID- 41455338 OWN - NLM STAT- MEDLINE DCOM- 20260119 LR - 20260119 IS - 1873-4162 (Electronic) IS - 1344-6223 (Linking) VI - 80 DP - 2026 Feb TI - Application of anatomical and histological features of testis to age estimation. PG - 102767 LID - S1344-6223(25)00201-9 [pii] LID - 10.1016/j.legalmed.2025.102767 [doi] AB - In forensic practice, when parts of an unidentified human body are found, age estimation with limited materials is required. This study investigated age-related anatomical and histological changes in testes to evaluate their applicability for forensic age estimation. Testicular samples from 228 male autopsy cases (aged 0-96 years) were analyzed. The Johnsen score, testicular weight, basement membrane thickness, number of seminiferous tubules per field, and percentage of hyalinized tubules were examined. Basement membrane thickness showed a strong positive correlation with age across all subjects (r = 0.733). In individuals under 20 years, testicular weight was positively correlated with age (r = 0.89), while the number of seminiferous tubules negatively correlated (r = - 0.90). In those aged >/= 20 years, Johnsen score, testicular weight, and hyalinization rate showed significant age-related differences between groups. Receiver operating characteristic curve analysis identified cutoff values for age discrimination: hyalinization rate of >/= 9.0 % for >/= 60 years (sensitivity 69.7 %, specificity 89.5 %), and testicular weight of /= 80 years (sensitivity 85.7 %, specificity 73.3 %). Basement membrane thickness, testicular weight, and seminiferous tubule count are useful indicators for forensic age estimation under 20 years of age; on the other hand, basement membrane thickness, testicular weight, and hyalinization rate are more informative in individuals aged >/= 20 years. These findings suggest the potential contribution of these indicators to forensic age estimation, while further studies are needed to validate their practical applicability. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Murai, Takato AU - Murai T AD - Department of Legal Medicine, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan; Department of Oral and Maxillofacial Surgery, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. Electronic address: murait@belle.shiga-med.ac.jp. FAU - Inoue, Masaki AU - Inoue M AD - Department of Legal Medicine, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan; Department of Oral and Maxillofacial Surgery, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. Electronic address: masa0629@belle.shiga-med.ac.jp. FAU - Mukaisho, Kenichi AU - Mukaisho K AD - Education Center for Medicine and Nursing, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. Electronic address: mukaisho@belle.shiga-med.ac.jp. FAU - Nakamura, Mami AU - Nakamura M AD - Department of Legal Medicine, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. Electronic address: mamin@belle.shiga-med.ac.jp. FAU - Takaoka, Kazuki AU - Takaoka K AD - Department of Oral and Maxillofacial Surgery, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. Electronic address: ktaka@belle.shiga-med.ac.jp. FAU - Hitosugi, Masahito AU - Hitosugi M AD - Department of Legal Medicine, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. Electronic address: hitosugi@belle.shiga-med.ac.jp. LA - eng PT - Journal Article DEP - 20251224 PL - Ireland TA - Leg Med (Tokyo) JT - Legal medicine (Tokyo, Japan) JID - 100889186 SB - IM MH - Humans MH - Male MH - *Testis/anatomy & histology/pathology MH - Adult MH - Adolescent MH - Child MH - Middle Aged MH - Infant MH - Child, Preschool MH - Aged MH - Young Adult MH - Aged, 80 and over MH - Infant, Newborn MH - Seminiferous Tubules/pathology MH - Basement Membrane/pathology MH - Organ Size OTO - NOTNLM OT - Age estimation OT - Forensic autopsy OT - Histology OT - Testis COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/28 01:36 MHDA- 2026/01/20 00:37 CRDT- 2025/12/27 18:08 PHST- 2025/09/19 00:00 [received] PHST- 2025/11/24 00:00 [revised] PHST- 2025/12/23 00:00 [accepted] PHST- 2026/01/20 00:37 [medline] PHST- 2025/12/28 01:36 [pubmed] PHST- 2025/12/27 18:08 [entrez] AID - S1344-6223(25)00201-9 [pii] AID - 10.1016/j.legalmed.2025.102767 [doi] PST - ppublish SO - Leg Med (Tokyo). 2026 Feb;80:102767. doi: 10.1016/j.legalmed.2025.102767. Epub 2025 Dec 24. PMID- 41454820 OWN - NLM STAT- MEDLINE DCOM- 20251227 LR - 20260502 IS - 0971-5916 (Print) IS - 0971-5916 (Linking) VI - 162 IP - 4 DP - 2025 Oct TI - Awareness & knowledge of frontline workers on infant & young child feeding (IYCF) practices: A qualitative study from Palghar-Maharashtra, India. PG - 437-444 LID - 10.25259/IJMR_986_2025 [pii] AB - Background & objectives Appropriate infant and young child feeding (IYCF) practices are crucial for growth and development during the first two years of life. Despite national initiatives, suboptimal IYCF practices prevail in tribal regions, contributing to undernutrition among under- five children. This necessitates need of specific targeted interventions through involvement of front line workers considering their role in community engagement. This study aims to assess awareness and knowledge of frontline workers about IYCF practices in Palghar district of Maharashtra. Methods This paper is part of a pre-intervention phase of a quasi-experimental study on IYCF practices in a tribal block of Palghar district, which included qualitative data through 56 in-depth interviews among frontline workers [anganwadi worker supervisor, anganwadi workers, and accredited social health activists (ASHAs)] to explore their awareness and knowledge on World Health Organization IYCF domains. Data were coded, thematically analysed, and responses were summarised descriptively to identify gaps for the intervention phase. Results While FLWs exhibited basic awareness of breastfeeding, there was limited knowledge among ASHAs on complementary feeding, minimum dietary diversity, minimum meal frequency and amylase rich flour preparation. While FLWs were aware of key IYCF messages, their implementation is uneven, likely due to limited refresher training, and the lack of user-friendly, validated tools. Interpretation & conclusions The study identified specific knowledge gaps in IYCF practices among frontline workers, particularly among ASHAs. There is an adequate scope for targeted health education to address misconceptions and supportive supervision to strengthen frontline workers' capacity to deliver accurate and consistent IYCF messages in tribal communities. FAU - Surve, Suchitra Vishwambhar AU - Surve SV AD - Department of Child Health Research, ICMR-National Institute for Research in Reproductive and Child Health, Dahanu, Mumbai, Maharashtra, India. FAU - Kyatam, Shraddha AU - Kyatam S AD - Department of Operational and Implementation Research, ICMR-National Institute for Research in Reproductive and Child Health, Dahanu, Mumbai, Maharashtra, India. FAU - M K, Bhavya AU - M K B AD - Department of Operational and Implementation Research, ICMR-National Institute for Research in Reproductive and Child Health, Dahanu, Mumbai, Maharashtra, India. FAU - Begum, Shahina AU - Begum S AD - Department of Biostatistics, ICMR-National Institute for Research in Reproductive and Child Health, Dahanu, Mumbai, Maharashtra, India. FAU - Kulkarni, Ragini Nitin AU - Kulkarni RN AD - Department of Operational and Implementation Research, ICMR-National Institute for Research in Reproductive and Child Health, Dahanu, Mumbai, Maharashtra, India. AD - Model Rural Health Research Unit, Dahanu, Mumbai, Maharashtra, India. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - Indian J Med Res JT - The Indian journal of medical research JID - 0374701 SB - IM MH - Humans MH - India/epidemiology MH - Infant MH - *Health Knowledge, Attitudes, Practice MH - *Breast Feeding MH - Female MH - *Community Health Workers MH - Child, Preschool MH - Male MH - Qualitative Research MH - Adult MH - *Infant Nutritional Physiological Phenomena MH - Frontline Workers PMC - PMC12744577 OTO - NOTNLM OT - Children OT - IYCF OT - complementary feeding OT - tribal OT - undernutrition COIS- None. EDAT- 2025/12/27 17:51 MHDA- 2025/12/27 17:52 PMCR- 2025/10/01 CRDT- 2025/12/27 07:49 PHST- 2025/04/21 00:00 [received] PHST- 2025/07/29 00:00 [accepted] PHST- 2025/12/27 17:52 [medline] PHST- 2025/12/27 17:51 [pubmed] PHST- 2025/12/27 07:49 [entrez] PHST- 2025/10/01 00:00 [pmc-release] AID - 10.25259/IJMR_986_2025 [pii] AID - 10.25259/IJMR_986_2025 [doi] PST - ppublish SO - Indian J Med Res. 2025 Oct;162(4):437-444. doi: 10.25259/IJMR_986_2025. PMID- 41454789 OWN - NLM STAT- MEDLINE DCOM- 20260322 LR - 20260322 IS - 1532-4303 (Electronic) IS - 0277-0903 (Linking) VI - 63 IP - 4 DP - 2026 Apr TI - Performance of the asthma clinical score and the Pediatric Respiratory Assessment Measure in obese children presenting to the emergency department for asthma exacerbations. PG - 492-500 LID - 10.1080/02770903.2025.2610341 [doi] AB - OBJECTIVE: Our primary objective was to evaluate the interrater reliability (IRR), responsiveness and predictive validity of two asthma severity scores in obese and normal weight (NW) children. Our secondary objective was to compare asthma interventions in these groups. METHODS: This was a planned secondary analysis of a prospective observational study of children aged 2-to- < 18 years treated for asthma exacerbations in the emergency department. Obesity was defined as >95th% sex-specific weight-for-age. Clinicians completed paired assessments of the Asthma Clinical Score (ACS) and Pediatric Respiratory Assessment Measure (PRAM). IRR was analyzed using Cohen's kappa coefficient. Reliable change index was used to determine the responsiveness. Predictive validity of the pretreatment ACS and PRAM was analyzed using Receiver Operating Characteristics and Akaike Information Criterion. The likelihood of receiving an intervention was described using odds ratios (OR). RESULTS: 399 Children were enrolled, 111 classified as obese. In obese children, the ACS showed moderate IRR, while the PRAM showed weak IRR (kappa(w) 0.73 and 0.57, respectively). Both scores better detected responsiveness in NW versus obese children (ACS 34% vs 23%, PRAM 28% vs 3.7%, respectively) but were better predictors of hospitalization in obese children (ACS 0.85, vs 0.74 and PRAM 0.79 vs 0.72, respectively). Obese children had higher odds of receiving intravenous methylprednisolone, continuous albuterol, and noninvasive ventilation. CONCLUSION: Performance of the ACS and PRAM varied between obese and NW children. Future studies should aim to fully elucidate the performance and utility of asthma severity scores in obese children. FAU - Andoh, Adjoa A AU - Andoh AA AUID- ORCID: 0000-0002-9535-1975 AD - Division of Emergency Medicine, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA. AD - The Ohio State University College of Medicine, Columbus, OH, USA. FAU - Truelove, Annie AU - Truelove A AD - Division of Emergency Medicine, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA. AD - The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. FAU - Helwig, Sara AU - Helwig S AD - Division of Emergency Medicine, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA. AD - The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. FAU - Nash, Matthew C AU - Nash MC AD - Division of Emergency Medicine, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA. AD - The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. FAU - Ulrich, Lisa AU - Ulrich L AUID- ORCID: 0000-0002-7232-2442 AD - The Ohio State University College of Medicine, Columbus, OH, USA. AD - Division of Pulmonary, Sleep Medicine and Cystic Fibrosis, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA. FAU - Shell, Richard AU - Shell R AD - The Ohio State University College of Medicine, Columbus, OH, USA. AD - Division of Pulmonary, Sleep Medicine and Cystic Fibrosis, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA. FAU - Leonard, Julie C AU - Leonard JC AD - Division of Emergency Medicine, Department of Pediatrics, Nationwide Children's Hospital, Columbus, OH, USA. AD - The Ohio State University College of Medicine, Columbus, OH, USA. AD - The Abigail Wexner Research Institute at Nationwide Children's Hospital, Columbus, OH, USA. LA - eng PT - Journal Article PT - Observational Study DEP - 20260105 PL - England TA - J Asthma JT - The Journal of asthma : official journal of the Association for the Care of Asthma JID - 8106454 RN - 0 (Anti-Asthmatic Agents) SB - IM MH - Humans MH - *Asthma/diagnosis/physiopathology/drug therapy/complications MH - Child MH - *Emergency Service, Hospital/statistics & numerical data MH - Male MH - Female MH - Child, Preschool MH - Prospective Studies MH - *Severity of Illness Index MH - *Pediatric Obesity/complications MH - Adolescent MH - Reproducibility of Results MH - Anti-Asthmatic Agents/therapeutic use OTO - NOTNLM OT - Pediatrics OT - prediction OT - reliability OT - treatment OT - weight EDAT- 2025/12/27 17:51 MHDA- 2026/03/23 01:33 CRDT- 2025/12/27 07:23 PHST- 2026/03/23 01:33 [medline] PHST- 2025/12/27 17:51 [pubmed] PHST- 2025/12/27 07:23 [entrez] AID - 10.1080/02770903.2025.2610341 [doi] PST - ppublish SO - J Asthma. 2026 Apr;63(4):492-500. doi: 10.1080/02770903.2025.2610341. Epub 2026 Jan 5. PMID- 41454347 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260626 IS - 0778-7367 (Print) IS - 2049-3258 (Electronic) IS - 0778-7367 (Linking) VI - 84 IP - 1 DP - 2025 Dec 27 TI - Outcomes and lessons from the integrated NCD-humanitarian response in Jordan (2020-2025). PG - 22 LID - 10.1186/s13690-025-01814-x [doi] LID - 22 AB - BACKGROUND: Jordan faces rising noncommunicable diseases (NCDs) amid protracted displacement. The 2020-2025 Integrated NCD-Humanitarian Response embedded NCD prevention and care across primary healthcare (PHC), humanitarian clinics, schools, and communities serving Jordanians and Syrian refugees. METHODS: An implementation-research case study synthesized routine service and biometric data, pre/post knowledge-attitude-practice (KAP) surveys, interviews/focus groups with providers, community health workers (CHWs), teachers, youth, and beneficiaries, and site observations. Outcomes included acceptability, appropriateness, adoption, feasibility, fidelity, penetration, effectiveness, and sustainability. Interventions adapted the Healthy Community Clinic (HCC) model, Healthy Schools Program, and youth/community outreach through provider training, standardized counseling tools, culturally adapted materials, and supportive supervision. Reach: >200 PHC centers plus NGO clinics, 319 schools, 119 CHWs, 48 community health committees, and 775 youth volunteers. RESULTS: Interventions were highly acceptable and appropriate, with strong adoption across PHC and humanitarian clinics and good school/community penetration. In Ministry of Health facilities, mean systolic/diastolic blood pressure fell by 10.5/5.0 mmHg and fasting glucose by 39.6 mg/dL (all p < 0.001); body mass index decreased by 0.6 Kg/m(2). In Al-Zaatari clinics, systolic blood pressure declined by 4.1 mmHg overall, with larger reductions among hypertensive patients; fasting glucose trended downward. KAP improved (> 40-point knowledge gains), physical inactivity dropped from 58.8% to 7.7% after three sessions, and vegetable intake roughly doubled. HCC roles, procedures, and indicators were incorporated into routine PHC operations and information systems, sustaining delivery beyond project facilitation. CONCLUSIONS: A context-tailored, multisector approach coupling PHC counseling with school and community action is feasible, effective, and increasingly institutionalized in humanitarian, resource-constrained settings. The model is scalable for strengthening NCD services for vulnerable populations in Jordan and similar contexts. FAU - Saad, Randa K AU - Saad RK AD - Research and Policy Department, Eastern Mediterranean Public Health Network, Amman, Jordan. randaksaad@gmail.com. FAU - Nsour, Abdullah Al AU - Nsour AA AD - Healthy Community Clinics Program, Royal Health Awareness Society, Amman, Jordan. FAU - Madsen, Jakob Sloth AU - Madsen JS AD - Policy, Programme and Partnerships, World Diabetes Foundation, Bagsvaerd, Denmark. FAU - Ireifij, Amal AU - Ireifij A AD - Royal Health Awareness Society, Amman, Jordan. FAU - Almohtaseb, Anas AU - Almohtaseb A AD - Primary Health Care Administration, Jordan Ministry of Health, Amman, Jordan. FAU - Alfakhoury, Saif AU - Alfakhoury S AD - Cardio-vascular and Diabetes Prevention Department, Jordan Ministry of Health, Amman, Jordan. FAU - Nabulsi, Mahmoud AU - Nabulsi M AD - Royal Health Awareness Society, Amman, Jordan. FAU - Ayyad, Mohammad AU - Ayyad M AD - Healthy Community Clinics Program, Royal Health Awareness Society, Amman, Jordan. FAU - Fanouneh, Saba Abu AU - Fanouneh SA AD - Healthy Community Clinics Program, Royal Health Awareness Society, Amman, Jordan. FAU - Khader, Yousef AU - Khader Y AD - Public Health, Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan. FAU - Farraj, Rami AU - Farraj R AD - Royal Health Awareness Society, Amman, Jordan. AD - Internal Medicine, King Hussein Medical Center, Amman, Jordan. LA - eng PT - Journal Article DEP - 20251227 PL - England TA - Arch Public Health JT - Archives of public health = Archives belges de sante publique JID - 9208826 PMC - PMC12853954 OTO - NOTNLM OT - Community5 OT - Humanitarian response2 OT - Integrated care3 OT - Noncommunicable diseases1 OT - Primary healthcare4 COIS- Declarations. Ethics approval and consent to participate: Ethical approval for conducting the IR was obtained from: the Institutional Review Board (IRB) at the MoH (MoH REC/2022/320 and MoH/REC/2023/469), the MoE (IRB protocol number 6918|10/3), the IRB at Jordan University of Science and Technology (IRB protocol number 52/143/2021), and the Health Sector Working Group research committee. The study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki. All participants were informed about the purpose of the study, assured of confidentiality, and provided written consent prior to participation. Participation was voluntary, and respondents could withdraw at any time without consequence. Consent for publication: Consent for publication was obtained from all participants involved in qualitative interviews and focus group discussions. No identifiable personal data are presented in this manuscript. Institutional and organizational partners reviewed and approved the publication of aggregated findings. The Jordan MoH, MoE, and RHAS granted permission to publish anonymized program data collected under the Integrated NCD-Humanitarian Response Project. Competing interests: The authors declare no competing interests. EDAT- 2025/12/27 00:54 MHDA- 2025/12/27 00:55 PMCR- 2025/12/27 CRDT- 2025/12/26 23:27 PHST- 2025/10/05 00:00 [received] PHST- 2025/12/07 00:00 [accepted] PHST- 2025/12/27 00:55 [medline] PHST- 2025/12/27 00:54 [pubmed] PHST- 2025/12/26 23:27 [entrez] PHST- 2025/12/27 00:00 [pmc-release] AID - 10.1186/s13690-025-01814-x [pii] AID - 1814 [pii] AID - 10.1186/s13690-025-01814-x [doi] PST - epublish SO - Arch Public Health. 2025 Dec 27;84(1):22. doi: 10.1186/s13690-025-01814-x. PMID- 41454183 OWN - NLM STAT- MEDLINE DCOM- 20260407 LR - 20261010 IS - 1476-5497 (Electronic) IS - 0307-0565 (Linking) VI - 50 IP - 4 DP - 2026 Apr TI - A prediction model for childhood obesity risk based on maternal thyroid status and related parameters using machine learning: a mother-newborn-offspring study in a mild-to-moderate iodine deficiency area. PG - 750-759 LID - 10.1038/s41366-025-01988-y [doi] AB - BACKGROUND: Childhood obesity and iodine deficiency are prevalent in developed countries and are linked to adverse health outcomes in adulthood. Mild-to-moderate iodine deficiency and insufficient maternal iodine intake during pregnancy may increase the risk of large-for-gestational-age newborns, which are associated with childhood obesity. Despite this, predicting childhood obesity during pregnancy remains a challenge. We assessed and evaluated machine learning algorithms predicting childhood obesity risk using maternal anthropometrics, thyroid function and iodine intake; and identified key prenatal factors contributing to childhood obesity. METHODS: A diagnostic accuracy study was conducted based on 87 parameters collected from a mother-newborn-offspring prospective cohort (N = 191) in a mild-to-moderate iodine deficiency region. Maternal iodine status and thyroid function, including serum free tri-iodo-thyronine (FT3) concentrations, were assessed during the second half of pregnancy. Iodine intake was evaluated using a semi-quantitative food frequency questionnaire. Anthropometric measurements were obtained from mothers during pregnancy, from newborns at birth, and from children at 2 years of age. An outcome of overweight at 2 years was defined as a gender-adjusted weight percentile >85%. The dataset was split into training (80%) and test (20%) sets. Synthetic datasets were created to evaluate the performance of six machine learning models, including artificial neural networks (Nnet) that trained and evaluated the model using 5-fold cross-validation. RESULTS: The best-performing model was Nnet, which achieved the highest accuracy (1500 instances with a balanced predicted outcome). On the unseen test data, accuracy, Kappa, outcome F1-score and weighted F1 were 0.743, 0.347, 0.500 and 0.769 (respectively). Significant predictors included gravidity, maternal-newborn anthropometrics (height and head circumference, respectively), maternal consumption and dietary intake of iodine-rich foods (popsicle, selected fish, and yogurt) and FT3. CONCLUSIONS: Machine learning approaches show promise in predicting childhood obesity risk using maternal and dietary factors during pregnancy. If validated, these findings could support interventions to reduce childhood obesity rates. CI - (c) 2025. The Author(s), under exclusive licence to Springer Nature Limited. FAU - Ovadia, Yaniv S AU - Ovadia YS AUID- ORCID: 0000-0001-9846-1515 AD - Obstetrics and Gynecology Division, Barzilai University Medical Center, Ashkelon, Israel. yaniv.ovadia@mail.huji.ac.il. FAU - Bilenko, Natalya AU - Bilenko N AD - Medical Office of Southern District, Ministry of Health, Ashkelon, Israel. AD - Faculty of Health Sciences, Ben-Gurion University of Negev, Beersheba, Israel. FAU - Mazza, Orit AU - Mazza O AD - Loewenstein Rehabilitation Medical Center, Ra'anana, Israel. AD - Clalit Health Services, Dan Petah-Tiqwa District, Petah Tikva, Israel. FAU - Fisch-Shvalb, Naama AU - Fisch-Shvalb N AUID- ORCID: 0000-0001-9612-6983 AD - The Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petach Tikva, Israel. AD - Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. FAU - Paradise Vit, Abigail AU - Paradise Vit A AD - Department of Information Systems, The Max Stern Emek Yezreel College, Emek Yezreel, Israel. FAU - Rosen, Shani R AU - Rosen SR AD - School of Nutritional Science; Institute of Biochemistry, Food Science and Nutrition; Robert H. Smith Faculty of Agriculture, Food and Environment; The Hebrew University of Jerusalem, Rehovot, Israel. FAU - Avrahami-Benyounes, Yael AU - Avrahami-Benyounes Y AD - Women's Health Center, Maccabi Healthcare Services, Southern Region, Beersheba, Israel. FAU - Groisman, Ludmila AU - Groisman L AD - National Public Health Laboratory, Ministry of Health, Tel Aviv, Israel. FAU - Rorman, Efrat AU - Rorman E AD - National Public Health Laboratory, Ministry of Health, Tel Aviv, Israel. FAU - Ketslakh, Tatiana AU - Ketslakh T AD - Obstetrics and Gynecology Division, Barzilai University Medical Center, Ashkelon, Israel. FAU - Anteby, Eyal Y AU - Anteby EY AD - Obstetrics and Gynecology Division, Barzilai University Medical Center, Ashkelon, Israel. AD - Faculty of Health Sciences, Ben-Gurion University of Negev, Beersheba, Israel. FAU - Gefel, Dov AU - Gefel D AD - Obstetrics and Gynecology Division, Barzilai University Medical Center, Ashkelon, Israel. FAU - Shenhav, Simon AU - Shenhav S AD - Obstetrics and Gynecology Division, Barzilai University Medical Center, Ashkelon, Israel. AD - Faculty of Health Sciences, Ben-Gurion University of Negev, Beersheba, Israel. LA - eng PT - Journal Article DEP - 20251226 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 RN - 9679TC07X4 (Iodine) SB - IM MH - Humans MH - *Iodine/deficiency MH - Female MH - *Machine Learning MH - *Pediatric Obesity/epidemiology/etiology MH - Pregnancy MH - Infant, Newborn MH - Male MH - Prospective Studies MH - Adult MH - Child, Preschool MH - Risk Factors MH - Mothers/statistics & numerical data MH - *Thyroid Gland/physiopathology COIS- Competing interests: YSO is a named inventor on a pending provisional patent application (U.S. Application No. 63/911,629) describing systems and methods for predicting and mitigating offspring health risks (including predictive models and methods presented in this manuscript). The remaining authors declare that they have no competing financial interests. EDAT- 2025/12/27 00:54 MHDA- 2026/04/08 00:30 CRDT- 2025/12/26 23:20 PHST- 2024/11/25 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2025/11/06 00:00 [revised] PHST- 2026/04/08 00:30 [medline] PHST- 2025/12/27 00:54 [pubmed] PHST- 2025/12/26 23:20 [entrez] AID - 10.1038/s41366-025-01988-y [pii] AID - 10.1038/s41366-025-01988-y [doi] PST - ppublish SO - Int J Obes (Lond). 2026 Apr;50(4):750-759. doi: 10.1038/s41366-025-01988-y. Epub 2025 Dec 26. PMID- 41454046 OWN - NLM STAT- MEDLINE DCOM- 20260407 LR - 20260919 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 185 IP - 1 DP - 2025 Dec 27 TI - Ultrasonographic predictors of extubation success in children: diaphragmatic, lung, and laryngeal assessment-a prospective pilot cohort study. PG - 42 LID - 10.1007/s00431-025-06677-6 [doi] LID - 42 AB - Extubation failure, occurring in 3-22% of pediatric intensive care unit (PICU) patients, contributes to increased morbidity, prolonged hospitalization, and healthcare costs. Point-of-care ultrasound (POCUS) provides a bedside, radiation-free method to assess extubation readiness. This pilot study evaluated the predictive value of lung, diaphragmatic, and laryngeal ultrasound for extubation success in mechanically ventilated children. In this prospective pilot study, 30 children (22 males, 8 females; aged 1 month-14 years) ventilated for > 24 h were enrolled. Patients with congenital diaphragmatic, pulmonary, or laryngeal abnormalities were excluded. Ultrasound examinations of the diaphragm, lungs, and larynx were performed within 24 h before and after extubation. Patients were classified as successful or failed extubation (reintubation within 48 h). Receiver operating characteristic (ROC) curve analysis was used to determine optimal cut-off values. Extubation succeeded in 18 (60%) and failed in 12 (40%) patients. Diaphragmatic excursion > 5.5 mm was the strongest predictor (sensitivity 100%, specificity 91.7%). Diaphragmatic thickening fraction > 29% (sensitivity 88.9%, specificity 66.7%); lung ultrasound score < 16.5 (sensitivity and specificity 80%); and body mass index > 14.8 (sensitivity 100%, specificity 63.6%) were also significant predictors. Reduced laryngeal air width difference moderately predicted failure (specificity 83.3%, p = 0.025). CONCLUSION: Diaphragmatic excursion and thickening fraction are the most accurate ultrasound predictors of extubation success, with lung and laryngeal assessments providing complementary insights. Combining these modalities may improve bedside evaluation of extubation readiness in critically ill children. WHAT IS KNOWN: * Extubation failure remains frequent in pediatric intensive care units, and currently used clinical predictors have limited reliability. * Bedside ultrasonography enables non-invasive assessment of diaphragmatic, pulmonary, and laryngeal function in critically ill children. WHAT IS NEW: * This pilot study integrates diaphragmatic, lung, and laryngeal ultrasonography into a single bedside extubation assessment strategy in children. * Diaphragmatic excursion and diaphragmatic thickening fraction emerged as the strongest ultrasound predictors of extubation success. CI - (c) 2025. The Author(s). FAU - Rezk, Ahmed R AU - Rezk AR AD - Pediatric Intensive Care Unit, Children's Hospital, Ain Shams University, Cairo, Egypt. FAU - Ibrahim, Hanan M AU - Ibrahim HM AD - Pediatric Intensive Care Unit, Children's Hospital, Ain Shams University, Cairo, Egypt. FAU - Yousry, Mahmoud AU - Yousry M AD - Pediatric Intensive Care Unit, Children's Hospital, Ain Shams University, Cairo, Egypt. FAU - Gamal, Assad AU - Gamal A AD - Radiology Department, Children's Hospital, Ain Shams University, Cairo, Egypt. FAU - Magdy, Sondos M AU - Magdy SM AUID- ORCID: 0000-0002-2832-7799 AD - Pediatric Intensive Care Unit, Children's Hospital, Ain Shams University, Cairo, Egypt. sondosmmagdy@med.asu.edu.eg. LA - eng PT - Journal Article DEP - 20251227 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Prospective Studies MH - Pilot Projects MH - *Ultrasonography/classification/methods MH - *Airway Extubation/classification/methods MH - Diaphragm/diagnostic imaging/pathology MH - Lung/diagnostic imaging/pathology MH - Larynx/diagnostic imaging/pathology MH - Intensive Care Units, Pediatric MH - *Point-of-Care Testing MH - Predictive Value of Tests MH - Humans MH - Male MH - Female MH - Infant, Newborn MH - Infant MH - Child, Preschool MH - Child MH - Adolescent MH - ROC Curve MH - Body Mass Index MH - Respiration, Artificial MH - *Ventilator Weaning/methods PMC - PMC12743022 OTO - NOTNLM OT - Critical care OT - Extubation failure OT - POCUS OT - Pediatric OT - Pilot study OT - Ultrasonography COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Faculty of Medicine, Ain Shams University Research Ethics Committee (FMASU REC; approval No. FMASU MD103/2023), which operates under Federal Wide Assurance No. FWA000017585. Written informed consent was obtained from parents or legal guardians prior to enrollment, in accordance with the Declaration of Helsinki. Consent for publication: Written informed consent for publication of the patient's clinical details was obtained from the parents or caregivers of patients. Competing interests: The authors declare no competing interests. EDAT- 2025/12/27 00:54 MHDA- 2025/12/27 00:55 PMCR- 2025/12/27 CRDT- 2025/12/26 23:17 PHST- 2025/10/13 00:00 [received] PHST- 2025/11/28 00:00 [accepted] PHST- 2025/11/15 00:00 [revised] PHST- 2025/12/27 00:55 [medline] PHST- 2025/12/27 00:54 [pubmed] PHST- 2025/12/26 23:17 [entrez] PHST- 2025/12/27 00:00 [pmc-release] AID - 10.1007/s00431-025-06677-6 [pii] AID - 6677 [pii] AID - 10.1007/s00431-025-06677-6 [doi] PST - epublish SO - Eur J Pediatr. 2025 Dec 27;185(1):42. doi: 10.1007/s00431-025-06677-6. PMID- 41453792 OWN - NLM STAT- MEDLINE DCOM- 20251226 LR - 20260106 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 12 DP - 2025 Dec 25 TI - Are adverse socioeconomic conditions in childhood associated with intrinsic capacity in older age? A cross-sectional study from the Lausanne cohort Lc65. PG - e097424 LID - 10.1136/bmjopen-2024-097424 [doi] LID - e097424 AB - OBJECTIVES: This study aimed to assess the associations between childhood adverse socioeconomic conditions and intrinsic capacity in older adults using an integrative approach to ageing. DESIGN: A cross-sectional study. SETTING: We used data from the Lausanne Cohort 65+, a population-based longitudinal study that has been conducted in Lausanne, Switzerland, since 2004. PARTICIPANTS: Lausanne citizens aged 67-71 years old. OUTCOMES: Intrinsic capacity was assessed in 2015 using validated self-reported measures and performance tests. Partial Least Squares Structural Equation Modelling was used in a formative approach to calculate the global score of intrinsic capacity and the scores of its domains. Adverse socioeconomic conditions in childhood were retrospectively assessed in 2014 using self-reported measures of financial strain, dietary restrictions and child labour. RESULTS: The study sample included 1328 individuals. Multivariable regressions revealed that the global score of intrinsic capacity was lower in individuals who reported financial strain (B=-0.15, p=0.029) and dietary restrictions (B=-0.314, p=0.004) in childhood. They further showed an association between financial strain and lower locomotor and sensory capacities (B=-0.173, p=0.011 and B=-0.153, p=0.027, respectively), and between child labour and a lower score on cognition (B=-0.342, p<0.001). CONCLUSIONS: Our results emphasise the critical role of early life conditions in healthy ageing. They highlight the importance of financial support for families and access to nutrition. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Plys, Ekaterina AU - Plys E AUID- ORCID: 0000-0002-0449-5296 AD - Department of Epidemiology and Health Systems, Unisante, Lausanne, Switzerland ekaterina.plys@unisante.ch. FAU - Fustinoni, Sarah AU - Fustinoni S AUID- ORCID: 0000-0001-8512-4210 AD - Department of Epidemiology and Health Systems, Unisante, Lausanne, Switzerland. FAU - Avendano, Mauricio AU - Avendano M AD - Department of Epidemiology and Health Systems, Unisante, Lausanne, Switzerland. FAU - Belloni, Giulia AU - Belloni G AD - Department of Epidemiology and Health Systems, Unisante, Lausanne, Switzerland. FAU - Blanco, Juan Manuel AU - Blanco JM AD - Department of Epidemiology and Health Systems, Unisante, Lausanne, Switzerland. FAU - Seematter-Bagnoud, Laurence AU - Seematter-Bagnoud L AD - Department of Epidemiology and Health Systems, Unisante, Lausanne, Switzerland. AD - Geriatric Medicine and Rehabilitation, University Hospital of Lausanne, Lausanne, Switzerland. FAU - Henchoz, Yves AU - Henchoz Y AUID- ORCID: 0000-0002-8251-8393 AD - Department of Epidemiology and Health Systems, Unisante, Lausanne, Switzerland. LA - eng PT - Journal Article DEP - 20251225 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Female MH - Switzerland MH - Aged MH - Socioeconomic Factors MH - Longitudinal Studies MH - Retrospective Studies MH - *Adverse Childhood Experiences/statistics & numerical data MH - Child MH - *Aging MH - *Financial Stress PMC - PMC12742142 OTO - NOTNLM OT - Aged OT - Aging OT - Cross-Sectional Studies OT - EPIDEMIOLOGY OT - Frail Elderly OT - PUBLIC HEALTH COIS- Competing interests: None declared. EDAT- 2025/12/27 00:54 MHDA- 2025/12/27 00:55 PMCR- 2025/12/25 CRDT- 2025/12/26 20:54 PHST- 2025/12/27 00:55 [medline] PHST- 2025/12/27 00:54 [pubmed] PHST- 2025/12/26 20:54 [entrez] PHST- 2025/12/25 00:00 [pmc-release] AID - bmjopen-2024-097424 [pii] AID - 10.1136/bmjopen-2024-097424 [doi] PST - epublish SO - BMJ Open. 2025 Dec 25;15(12):e097424. doi: 10.1136/bmjopen-2024-097424. PMID- 41452894 OWN - NLM STAT- MEDLINE DCOM- 20251226 LR - 20251229 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 12 DP - 2025 TI - Spiritual well-being as a protective factor for endothelial dysfunction in clinically healthy adults. PG - e0339676 LID - 10.1371/journal.pone.0339676 [doi] LID - e0339676 AB - BACKGROUND: Endothelial dysfunction (ED) is an early marker of cardiovascular disease (CVD), influenced by both physiological and psychosocial factors. While depression and anxiety are known contributors to ED, the role of spiritual well-being (SWB) in vascular health has been relatively less explored in the literature. OBJECTIVE: To investigate the association between SWB and ED in clinically healthy adults, controlling for mental health variables and conventional cardiovascular risk factors. METHODS: In this cross-sectional study, 148 individuals aged 18-60 years were assessed using validated instruments: FACIT-Sp for SWB, PHQ-9 for depression, GAD-7 for anxiety, and brachial artery flow-mediated dilation (FMD) for endothelial function. Logistic regression and discriminant analyses were performed to identify independent predictors of ED and the spiritual dimensions most associated with vascular health. RESULTS: ED was identified in 39.2% of participants. Multivariate logistic regression indicated that SWB (OR = 0.929; p = 0.005), body mass index (OR = 1.130; p = 0.016), generalized anxiety disorder (OR = 2.551; p = 0.035), and major depressive episode (OR = 3.740; p = 0.038), were significantly associated with ED. Among these, SWB was significantly inversely associated with ED even after excluding participants with anxiety or depression. Discriminant analysis further indicated that inner peace and life purpose-but not faith-significantly distinguished individuals with and without ED. CONCLUSION: SWB, particularly dimensions related to inner peace and meaning, is independently associated with preserved endothelial function in healthy adults. These findings support the inclusion of psychosocial and spiritual dimensions in cardiovascular risk assessment and prevention strategies. CI - Copyright: (c) 2025 Casarsa et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Casarsa, Andre AU - Casarsa A AUID- ORCID: 0000-0003-1043-9335 AD - Department of Internal Medicine, University Hospital Gaffree Guinle, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. AD - Postgraduate Neurology Department, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Bastos de Medeiros, Pedro AU - Bastos de Medeiros P AUID- ORCID: 0009-0006-9558-2235 AD - Department of Internal Medicine, University Hospital Gaffree Guinle, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. AD - Department of Internal Medicine, University Hospital Clementino Fraga Filho, Medical School, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Tolentino, Julio Cesar AU - Tolentino JC AUID- ORCID: 0000-0002-2524-9836 AD - Department of Internal Medicine, University Hospital Gaffree Guinle, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. AD - Postgraduate Neurology Department, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Guimaraes, Isadora de Sa AU - Guimaraes IS AUID- ORCID: 0009-0001-2489-3304 AD - Department of Internal Medicine, University Hospital Gaffree Guinle, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Cruz, Kelen Carolina Silva AU - Cruz KCS AD - Department of Internal Medicine, University Hospital Gaffree Guinle, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Dos Santos, Leticia Silva Flor AU - Dos Santos LSF AUID- ORCID: 0009-0002-2658-2443 AD - Department of Internal Medicine, University Hospital Gaffree Guinle, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Tinoco, Matheus Nakazato AU - Tinoco MN AUID- ORCID: 0009-0004-6734-3451 AD - Department of Internal Medicine, University Hospital Gaffree Guinle, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Dias, Maria de Fatima Martins Gil AU - Dias MFMG AUID- ORCID: 0009-0003-0572-1069 AD - Postgraduate Neurology Department, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Gjorup, Ana Lucia Taboada AU - Gjorup ALT AD - Department of Internal Medicine, University Hospital Gaffree Guinle, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. AD - Postgraduate Neurology Department, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Schmidt, Sergio Luis AU - Schmidt SL AUID- ORCID: 0000-0001-7654-5507 AD - Department of Internal Medicine, University Hospital Gaffree Guinle, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil. AD - Postgraduate Neurology Department, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro, Rio de Janeiro, Brazil. LA - eng PT - Journal Article DEP - 20251226 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adult MH - Male MH - Female MH - Middle Aged MH - *Spirituality MH - Cross-Sectional Studies MH - *Endothelium, Vascular/physiopathology MH - Young Adult MH - Adolescent MH - *Cardiovascular Diseases/psychology/physiopathology MH - Depression MH - Risk Factors MH - Anxiety MH - Protective Factors PMC - PMC12742740 COIS- The authors have declared that no competing interests exist. EDAT- 2025/12/26 18:29 MHDA- 2025/12/26 18:30 PMCR- 2025/12/26 CRDT- 2025/12/26 13:43 PHST- 2025/06/19 00:00 [received] PHST- 2025/12/08 00:00 [accepted] PHST- 2025/12/26 18:30 [medline] PHST- 2025/12/26 18:29 [pubmed] PHST- 2025/12/26 13:43 [entrez] PHST- 2025/12/26 00:00 [pmc-release] AID - PONE-D-25-31113 [pii] AID - 10.1371/journal.pone.0339676 [doi] PST - epublish SO - PLoS One. 2025 Dec 26;20(12):e0339676. doi: 10.1371/journal.pone.0339676. eCollection 2025. PMID- 41452891 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251226 LR - 20251230 IS - 2767-3375 (Electronic) IS - 2767-3375 (Linking) VI - 5 IP - 12 DP - 2025 TI - Conducting non-pandemic research during the COVID-19 pandemic: A case study and documentary review. PG - e0005702 LID - 10.1371/journal.pgph.0005702 [doi] LID - e0005702 AB - The COVID-19 pandemic presented unprecedented challenges to the conduct of non-pandemic research. The pandemic disrupted regulatory processes, strained health systems, and necessitated ethical recalibrations. This paper is a case study retrospectively examining the experience of conducting one non-pandemic clinical study of infant nutritional supplements in western Kenya between October 2020 and January 2024. The original study documents were reviewed to identify lessons learned, particularly those relevant to ethical and regulatory aspects of conducting non-pandemic research during a pandemic. A retrospective documentary case analysis was conducted using the archived ethics and regulatory submissions, feedback received during those submissions, study progress reports, meeting minutes, and relevant peer-reviewed literature. A framework analysis approach guided thematic coding, supported by independent dual review to ensure reliability (Cohen's Kappa >/=0.6). Public health restrictions during the third pandemic wave, particularly at the main recruitment site, compounded delays. Adaptive measures included reduced physical contact, use of satellite recruitment centers, community engagement with Traditional Birth Attendants, and remote monitoring via digital platforms. Parallel submission to both the Ethics Review Committee and the Regulatory Authority notably expedited the overall turnaround time for approval of protocol amendments. Despite these challenges, the study achieved an impressive 91% follow-up completion rate, with 96% of scheduled home visits successfully carried out. This case study highlights how flexible, community-informed, and ethically responsive research practices can sustain clinical trials under adverse conditions. Strong stakeholder collaboration, open communication, and proactive risk mitigation were essential to maintaining study integrity and protecting participant welfare. These findings underscore the need for future research designs to embed contingency planning, community partnerships, and regulatory adaptability to ensure continuity and resilience for research conducted during public health emergencies. CI - Copyright: (c) 2025 June et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - June, Micah J AU - June MJ AUID- ORCID: 0000-0001-9077-842X AD - Department of Public Health, Pharmacology and Toxicology, University of Nairobi, Nairobi, Kenya. AD - Centre for Global Health Research, Kenya Medical Research Institute (KEMRI), Kisumu, Kenya. FAU - Otiti, Mary I AU - Otiti MI AUID- ORCID: 0000-0002-5514-6846 AD - Centre for Global Health Research, Kenya Medical Research Institute (KEMRI), Kisumu, Kenya. AD - Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom. FAU - Mbanda, Nicodemus O AU - Mbanda NO AD - Centre for Global Health Research, Kenya Medical Research Institute (KEMRI), Kisumu, Kenya. FAU - Miruye, Polland O AU - Miruye PO AD - Centre for Global Health Research, Kenya Medical Research Institute (KEMRI), Kisumu, Kenya. FAU - Allen, Stephen J AU - Allen SJ AUID- ORCID: 0000-0001-6675-249X AD - Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, United Kingdom. FAU - O'Mathuna, Donal AU - O'Mathuna D AUID- ORCID: 0000-0001-5331-3340 AD - College of Nursing and Center for Bioethics, The Ohio State University, Columbus, Ohio, United States of America. LA - eng GR - R25 TW012217/TW/FIC NIH HHS/United States PT - Journal Article DEP - 20251226 PL - United States TA - PLOS Glob Public Health JT - PLOS global public health JID - 9918283779606676 PMC - PMC12742765 COIS- The authors have declared that no competing interests exist. EDAT- 2025/12/26 18:29 MHDA- 2025/12/26 18:30 PMCR- 2025/12/26 CRDT- 2025/12/26 13:43 PHST- 2025/06/28 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2025/12/26 18:30 [medline] PHST- 2025/12/26 18:29 [pubmed] PHST- 2025/12/26 13:43 [entrez] PHST- 2025/12/26 00:00 [pmc-release] AID - PGPH-D-25-01630 [pii] AID - 10.1371/journal.pgph.0005702 [doi] PST - epublish SO - PLOS Glob Public Health. 2025 Dec 26;5(12):e0005702. doi: 10.1371/journal.pgph.0005702. eCollection 2025. PMID- 41452801 OWN - NLM STAT- MEDLINE DCOM- 20251226 LR - 20260813 IS - 2219-6749 (Electronic) IS - 0258-414X (Print) IS - 0258-414X (Linking) VI - 43 IP - 3 DP - 2025 Dec 24 TI - End-to-end vs. human-defined feature extraction: comparing deep learning approaches for age classification using mandibular third molars. PG - 20-30 LID - 10.5281/zenodo.17776415 [doi] AB - Accurate age classification using mandibular third molar radiographs is crucial for legal and forensic applications. This study evaluated different methods for classifying age as under or over 18 years in a Thai population. We compared three approaches: (i) a traditional human-based method using a modified Demirjian classification adapted for mandibular third molars, (ii) an end-to-end deep learning model in which a convolutional neural network (CNN) directly predicts age group, and (iii) a human-defined feature extraction approach, where a CNN estimates tooth developmental stages that are subsequently used for age classification. The dataset included 3,407 images of individuals aged 14-23 years. The results indicated that the traditional human-based method achieved high specificity (0.99) and a strong Bayes' post-test probability (0.99), but it exhibited low sensitivity (0.45). In comparison, the end-to-end deep learning models showed higher sensitivity (0.65 to 0.74) than the traditional method, along with a specificity of 0.91 to 0.95 and Bayes' post-test probability of 0.93 to 0.95. The human-defined feature extraction approach, which used developmental stages for age determination, achieved an accuracy of 0.88 to 0.92 in developmental stage classification. For age classification, the models demonstrated higher specificity (0.95 to 0.97) and Bayes' post-test probability (0.95 to 0.97) than the end-to-end deep learning method, along with sensitivity ranging from 0.51 to 0.56. Our results indicate that although traditional methods excel in specificity, the human-defined feature extraction approach provides a balanced solution with high specificity and interpretability, suggesting its potential value in clinical practice for age estimation. CI - Copyright(c) 2025 IOFOS This work is published and licensed by International Organization for Forensic Odonto-Stomatology. FAU - Upalananda, Witsarut AU - Upalananda W AUID- ORCID: 0000-0002-3972-9785 AD - Department of Oral Diagnostic Sciences, Faculty of Dentistry, Prince of Songkla University, Songkhla, Thailand. FAU - Charuakkra, Arnon AU - Charuakkra A AUID- ORCID: 0009-0002-4765-2447 AD - Department of Oral Biology and Oral Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand. FAU - Chaichulee, Sitthichok AU - Chaichulee S AUID- ORCID: 0000-0002-3159-7925 AD - Department of Biomedical Sciences and Biomedical Engineering, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand. LA - eng PT - Comparative Study PT - Journal Article DEP - 20251224 PL - Australia TA - J Forensic Odontostomatol JT - The Journal of forensic odonto-stomatology JID - 8501421 SB - IM MH - Humans MH - *Molar, Third/diagnostic imaging/growth & development MH - *Deep Learning MH - *Age Determination by Teeth/methods MH - Adolescent MH - Mandible MH - Young Adult MH - Bayes Theorem MH - Sensitivity and Specificity MH - Male MH - Neural Networks, Computer MH - Female MH - Radiography, Panoramic PMC - PMC12906364 OTO - NOTNLM OT - Deep learning OT - Dental age estimation OT - Forensic odontology OT - Mandibular third molar COIS- The authors report no conflicts of interest in this work. EDAT- 2025/12/26 18:29 MHDA- 2025/12/26 18:30 PMCR- 2026/04/01 CRDT- 2025/12/26 13:22 PHST- 2025/12/26 18:30 [medline] PHST- 2025/12/26 18:29 [pubmed] PHST- 2025/12/26 13:22 [entrez] PHST- 2026/04/01 00:00 [pmc-release] AID - JFOS-43-3-20 [pii] AID - 10.5281/zenodo.17776415 [doi] PST - epublish SO - J Forensic Odontostomatol. 2025 Dec 24;43(3):20-30. doi: 10.5281/zenodo.17776415. PMID- 41452440 OWN - NLM STAT- MEDLINE DCOM- 20260406 LR - 20261010 IS - 1720-8386 (Electronic) IS - 0391-4097 (Linking) VI - 49 IP - 4 DP - 2026 Apr TI - TRISOMY 21: development of syndrome-specific growth charts from a wide Italian cohort and validation of BMI as a predictor of increased risk of metabolic derangement. PG - 931-946 LID - 10.1007/s40618-025-02777-0 [doi] AB - PURPOSE: The growth charts for individuals with Down syndrome (DS) available to-date were developed from a cohort of patients from the USA. As diet and environmental factors play a key role on auxological attainment, the growth of patients from the Mediterranean area should be assessed by means of dedicated centiles. Accordingly, we aimed to develop growth charts from a wide Italian population and to provide a metabolic validation for the BMI distribution outlined. METHODS: Retrospective, bicentric study. We gathered auxological and biochemical data from two cohorts of Italian children and adolescents with DS assessed every 6- to 12-months between 1992 and 2024. RESULTS: 526 patients were enrolled. We longitudinally retrieved the auxological data recorded in the setting of 2796 clinical evaluations. By assessing height, weight and BMI with reference to age, we outlined the age-dependent distribution of each parameter and developed syndrome-specific growth charts. When comparing our charts with the USA ones, the latter showed a statistically greater upward trendline in weight and BMI. Eventually, we assessed the distribution of triglycerides, cholesterol, glycated hemoglobin and uric acid with reference to the BMI. A higher BMI centile was statistically associated with greater triglycerides, cholesterol, and uric acid levels, and we identified the 90th centile of BMI as a risk threshold for dyslipidemia and hyperuricemia. CONCLUSION: We developed DS-specific growth charts from a wide Italian population. The comparison with the USA percentiles outlined statistically significant differences in the distribution of weight and BMI, thus highlighting the need of dedicated charts for individuals from the Mediterranean area. CI - (c) 2025. The Author(s), under exclusive licence to Italian Society of Endocrinology (SIE). FAU - Cattoni, Alessandro AU - Cattoni A AUID- ORCID: 0000-0001-6933-6723 AD - Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900, Monza, MB, Italy. alessandro.cattoni@unimib.it. FAU - Molinari, Silvia AU - Molinari S AD - Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900, Monza, MB, Italy. FAU - Cali, Luisa AU - Cali L AD - School of Medicine and Surgery, University of Milano-Bicocca, Monza, MB, Italy. FAU - Riva, Benedetta AU - Riva B AD - School of Medicine and Surgery, University of Milano-Bicocca, Monza, MB, Italy. FAU - Nicolosi, Maria Laura AU - Nicolosi ML AD - Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900, Monza, MB, Italy. FAU - Fossati, Chiara AU - Fossati C AD - Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900, Monza, MB, Italy. FAU - Gazzarri, Alessandra AU - Gazzarri A AD - Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900, Monza, MB, Italy. AD - Vivi Down Odv, Milano, MI, Italy. FAU - Lattuada, Martina AU - Lattuada M AD - School of Medicine and Surgery, University of Milano-Bicocca, Monza, MB, Italy. FAU - Medici, Francesco AU - Medici F AD - School of Medicine and Surgery, University of Milano-Bicocca, Monza, MB, Italy. FAU - Carzaniga, Viola AU - Carzaniga V AD - School of Medicine and Surgery, University of Milano-Bicocca, Monza, MB, Italy. FAU - Carnevale, Riccardo AU - Carnevale R AD - School of Medicine and Surgery, University of Milano-Bicocca, Monza, MB, Italy. FAU - Pangallo, Elisabetta AU - Pangallo E AD - School of Medicine and Surgery, University of Milano-Bicocca, Monza, MB, Italy. FAU - Primi, Marianna AU - Primi M AD - B4 Center of Bioinformatics, Biostatistics e Bioimaging, University of Milano-Bicocca, Vedano al Lambro, MB, Italy. FAU - Bonfanti, Cristina AU - Bonfanti C AD - Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900, Monza, MB, Italy. FAU - Balduzzi, Adriana AU - Balduzzi A AD - Department of Pediatrics, Fondazione IRCCS San Gerardo dei Tintori, 20900, Monza, MB, Italy. AD - School of Medicine and Surgery, University of Milano-Bicocca, Monza, MB, Italy. FAU - Capitoli, Giulia AU - Capitoli G AD - B4 Center of Bioinformatics, Biostatistics e Bioimaging, University of Milano-Bicocca, Vedano al Lambro, MB, Italy. AD - Biostatistics and Clinical Epidemiology, Fondazione IRCCS San Gerardo dei Tintori, Monza, MB, Italy. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20251226 PL - Italy TA - J Endocrinol Invest JT - Journal of endocrinological investigation JID - 7806594 SB - IM MH - Humans MH - *Down Syndrome/epidemiology/complications/physiopathology/diagnosis MH - Female MH - Male MH - *Body Mass Index MH - Italy/epidemiology MH - Retrospective Studies MH - Child MH - Adolescent MH - *Growth Charts MH - Child, Preschool MH - *Metabolic Syndrome/epidemiology/diagnosis/etiology MH - Infant MH - Risk Factors MH - Prognosis MH - Follow-Up Studies MH - Body Height MH - Body Weight OTO - NOTNLM OT - Body mass index OT - Cholesterol OT - Down syndrome OT - Growth charts OT - Metabolism OT - Uric acid COIS- Declarations. Competing interests: The authors have no competing interests to declare that are relevant to the content of this article. EDAT- 2025/12/26 13:39 MHDA- 2026/04/06 18:33 CRDT- 2025/12/26 11:07 PHST- 2025/07/27 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2026/04/06 18:33 [medline] PHST- 2025/12/26 13:39 [pubmed] PHST- 2025/12/26 11:07 [entrez] AID - 10.1007/s40618-025-02777-0 [pii] AID - 10.1007/s40618-025-02777-0 [doi] PST - ppublish SO - J Endocrinol Invest. 2026 Apr;49(4):931-946. doi: 10.1007/s40618-025-02777-0. Epub 2025 Dec 26. PMID- 41451459 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260504 LR - 20260504 IS - 2192-5682 (Print) IS - 2192-5690 (Electronic) IS - 2192-5682 (Linking) VI - 16 IP - 4 DP - 2026 May TI - Scoliosis School Screening Using Electronic Devices in Henan Province, China: An Exploratory Study. PG - 1950-1956 LID - 10.1177/21925682251411255 [doi] AB - Study DesignAn Exploratory Study.ObjectivesTo estimate the prevalence of scoliosis and associated factors among adolescents, and to evaluate the clinical utility of an electronic scoliometer in school screening.MethodsThe scoliosis school screening was conducted in Xinyang City, Henan Province, in 2024. Students' study habits and daily routines were collected via questionnaires. Manual and electronic scoliometers were used for primary screening and compared using receiver operating characteristic (ROC) curves and agreement statistics. Three-dimensional ultrasound provided a provisional diagnosis. Multivariable logistic regression identified factors associated with scoliosis.ResultsA total of 1874 students were enrolled in this study. The positive screening rates using manual and electronic scoliometers were 4.97% and 2.87%, respectively. Among these cases, 102 students were referred for 3D ultrasound examination, with 74 students showing an ultrasound Cobb angle >/=10 degrees . The prevalence of scoliosis was 4.55% in seventh-grade students and 4.04% in eighth-grade students. The prevalence of scoliosis was 2.99% in males and 5.96% in females. In the paired sample (n = 39), the electronic device had an AUC of 0.844 (95% CI 0.718-0.971) vs 0.751 (95% CI 0.596-0.907) for the manual device (DeltaAUC = 0.093, P = 0.033). Agreement for continuous ATR showed moderate absolute agreement (ICC(3,1) = 0.614; 95% CI 0.373-0.777). Multinomial regression identified sitting with crossed legs and lack of sports participation as potential risk factors.ConclusionsThe prevalence of scoliosis among seventh and eighth-grade students in Xinyang City, Henan Province, was 4.33%. We recommend ATR >/=5 degrees be triaged with 3D ultrasound before radiography; cases with UCA <20 degrees should be rechecked at 3 months. Schools/parents should promote correct seated posture and more physical activity. FAU - Xia, Weiwei AU - Xia W AUID- ORCID: 0000-0003-3272-5084 AD - Department of Spinal Surgery, Peking University People's Hospital, Peking University, Beijing, P.R. China. FAU - Li, Hongzhen AU - Li H AUID- ORCID: 0009-0006-3804-4860 AD - Department of Spinal Surgery, Peking University People's Hospital, Peking University, Beijing, P.R. China. FAU - Zhu, Shuaiqi AU - Zhu S AUID- ORCID: 0009-0006-2706-9675 AD - Department of Spinal Surgery, Peking University People's Hospital, Peking University, Beijing, P.R. China. FAU - Zhao, Chong AU - Zhao C AUID- ORCID: 0009-0004-5362-3524 AD - Department of Spinal Surgery, Peking University People's Hospital, Peking University, Beijing, P.R. China. FAU - Hou, Bing AU - Hou B AD - Beijing Haiying Spine Health Public Welfare, Beijing, P.R. China. FAU - Zhu, Zhijie AU - Zhu Z AD - School of Statistics, Dongbei University of Finance and Economics, Dalian, P.R. China. RINGGOLD: 12688 FAU - Zheng, Yongping AU - Zheng Y AD - Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong. RINGGOLD: 26680 FAU - Yang, De AU - Yang D AD - Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong. RINGGOLD: 26680 FAU - Dong, Yanhui AU - Dong Y AUID- ORCID: 0000-0003-2519-3200 AD - Institute of Child and Adolescent Health, School of Public Health, Peking University, Beijing, China. RINGGOLD: 12465 FAU - Liu, Haiying AU - Liu H AUID- ORCID: 0000-0003-4667-3297 AD - Department of Spinal Surgery, Peking University People's Hospital, Peking University, Beijing, P.R. China. FAU - Xu, Shuai AU - Xu S AUID- ORCID: 0000-0002-3702-4714 AD - Department of Spinal Surgery, Peking University People's Hospital, Peking University, Beijing, P.R. China. AD - Orthopedics Department, Beijing Huasheng Rehabilitation Hospital, Beijing, P.R. China. LA - eng PT - Journal Article DEP - 20251226 PL - England TA - Global Spine J JT - Global spine journal JID - 101596156 PMC - PMC12743008 OTO - NOTNLM OT - daily routines OT - electronic scoliometer OT - manual scoliometer OT - scoliosis school screening OT - study habits OT - three-dimensional ultrasound COIS- Declaration of Conflicting InterestsThe author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/12/26 07:40 MHDA- 2025/12/26 07:41 PMCR- 2025/12/26 CRDT- 2025/12/26 04:52 PHST- 2025/12/26 07:41 [medline] PHST- 2025/12/26 07:40 [pubmed] PHST- 2025/12/26 04:52 [entrez] PHST- 2025/12/26 00:00 [pmc-release] AID - 10.1177_21925682251411255 [pii] AID - 10.1177/21925682251411255 [doi] PST - ppublish SO - Global Spine J. 2026 May;16(4):1950-1956. doi: 10.1177/21925682251411255. Epub 2025 Dec 26. PMID- 41450885 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251226 LR - 20251228 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 13 DP - 2025 TI - Protein supplementation in pediatric oncology: a systematic review revealing a lack of evidence and insights from other chronically and critically ill children. PG - 1724658 LID - 10.3389/fped.2025.1724658 [doi] LID - 1724658 AB - BACKGROUND & AIMS: Exercise interventions may counteract adverse effects of childhood cancer (treatment) on anthropometrics, body composition and physical fitness. However, inadequate nutritional status and loss of muscle mass and strength might limit effectiveness. Protein supplementation might support muscle preservation and enhance the benefits of exercise but evidence on its effect in children with cancer is lacking. This review examined the potential effect of protein supplementation on anthropometrics, body composition, physical fitness and adverse effects in children with cancer from diagnosis until two years after end of treatment. METHODS: PubMed/MEDLINE was searched for literature on childhood cancer and protein supplementation (14th of May 2025). Reports examining anthropometrics, body composition and/or physical fitness before and after the protein intervention and written in English were eligible. Another search was performed in chronically and critically ill children (14th of May 2025). Risk of bias was assessed using Cochrane Childhood Cancer criteria and for each outcome, we graded the quality of evidence using the Grading of Recommendations Assessment, Development and Evaluation methodology. Data were descriptively reported. RESULTS: None of the studies in children with cancer could be included. Five studies were included with a total of 142 children (66 had cystic fibrosis, 6 Crohn's disease, 70 a prolonged pediatric intensive care unit stay). Protein supplementation interventions varied. All studies reported on anthropometrics and body composition. Four observational studies reported a significant improvement in at least one of the outcomes whereas one randomized controlled trial (RCT) found no significant changes. Of the three studies assessing physical fitness measurements, two observational studies reported a significant improvement in at least one of the outcomes while one RCT did not find a significant change. The three studies reporting on adverse effects were encouraging but this outcome deserves further investigation. Level of evidence was graded very low for all outcomes. CONCLUSIONS: Evidence on the potential of protein supplementation is scarce and not available in children with cancer. The limited evidence included in this review tentatively suggests that protein supplementation might aid in improving anthropometrics, body composition and physical fitness. Future controlled trials are needed to determine its feasibility and effectiveness in children with cancer. CI - (c) 2025 den Hartog, van Tongeren, van Dalen, van den Brink, Verwaaijen and Tissing. FAU - den Hartog, Emma AU - den Hartog E AD - Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands. FAU - van Tongeren, Jose AU - van Tongeren J AD - Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands. FAU - van Dalen, Elvira C AU - van Dalen EC AD - Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands. FAU - van den Brink, Mirjam AU - van den Brink M AD - Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands. FAU - Verwaaijen, Emma J AU - Verwaaijen EJ AD - Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands. FAU - Tissing, Wim J E AU - Tissing WJE AD - Princess Maxima Center for Pediatric Oncology, Utrecht, Netherlands. AD - Department of Pediatric Oncology and Hematology, University of Groningen, Beatrix Children's Hospital, University Medical Center Groningen, Groningen, Netherlands. LA - eng PT - Journal Article PT - Systematic Review DEP - 20251210 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC12728054 OTO - NOTNLM OT - adverse effects OT - anthropometrics OT - body composition OT - chronic illness OT - critical illness OT - pediatric oncology OT - physical fitness OT - protein supplementation COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The handling editor declared a past co-authorship with the author EV. EDAT- 2025/12/26 07:40 MHDA- 2025/12/26 07:41 PMCR- 2025/12/10 CRDT- 2025/12/26 04:40 PHST- 2025/10/14 00:00 [received] PHST- 2025/11/21 00:00 [revised] PHST- 2025/11/25 00:00 [accepted] PHST- 2025/12/26 07:41 [medline] PHST- 2025/12/26 07:40 [pubmed] PHST- 2025/12/26 04:40 [entrez] PHST- 2025/12/10 00:00 [pmc-release] AID - 10.3389/fped.2025.1724658 [doi] PST - epublish SO - Front Pediatr. 2025 Dec 10;13:1724658. doi: 10.3389/fped.2025.1724658. eCollection 2025. PMID- 41450515 OWN - NLM STAT- MEDLINE DCOM- 20251226 LR - 20260822 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Culturally responsive recruitment of Black daughter-mother dyads through community engagement. PG - 1634312 LID - 10.3389/fpubh.2025.1634312 [doi] LID - 1634312 AB - INTRODUCTION: Black Girls Move is a 12-week, race-conscious, multicomponent, mHealth obesity prevention intervention for Black 7th-10th grade daughters and their mothers. The complex experiences of Black female adolescents and adults necessitate tailored recruitment and retention strategies to address structural, programmatic, and interpersonal barriers to participation. We outline culturally responsive recruitment and retention strategies, lessons learned, and their implications. METHODS: A review of recruitment literature highlighted trust-building as essential. We utilized guidelines for evaluating recruitment feasibility in pilot studies and the Community-Informed Recruitment Plan template of diverse populations as frameworks to assess and refine our recruitment and retention approach. RESULTS: Key findings included: (1) trust was critical for sustaining participant relationships from screening to baseline, (2) weight eligibility criteria were overly restrictive, (3) recruitment targets needed adjustment to prevent school loss, and (4) competing demands impacted engagement. Refinements involved consulting community leaders and an expert community research consultant, leading to (1) broadening eligibility criteria to include daughters of all weight statuses and 7th-8th graders; (2) increasing incentives to align compensation with time commitments for surveys; and (3) hiring a community health worker to address communication and scheduling issues while fostering trust. DISCUSSION: Strengthening trust, expanding eligibility, and improving incentives enhanced recruitment and participant engagement. We found this culturally tailored, race-conscious approach was valuable in refining recruitment strategies. Future studies should test the guidelines for evaluating the feasibility of recruitment and the Community-Informed Recruitment Plan template of diverse populations in a large-scale randomized control trial. CI - Copyright (c) 2025 Banks, Julion, Halloway, Kitsiou, Schoeny, Swanson, Webber-Ritchey, Wilhelm, Yeager and Reed. FAU - Banks, Tristan AU - Banks T AD - College of Nursing, Rush University, Chicago, IL, United States. FAU - Julion, Wrenetha AU - Julion W AD - College of Nursing, Rush University, Chicago, IL, United States. FAU - Halloway, Shannon AU - Halloway S AD - College of Nursing, University of Illinois Chicago, Chicago, IL, United States. FAU - Kitsiou, Spyros AU - Kitsiou S AD - College of Applied Health Sciences, University of Illinois Chicago, Chicago, IL, United States. FAU - Schoeny, Michael AU - Schoeny M AD - College of Nursing, Rush University, Chicago, IL, United States. FAU - Swanson, Barbara AU - Swanson B AD - College of Nursing, Rush University, Chicago, IL, United States. FAU - Webber-Ritchey, Kashica AU - Webber-Ritchey K AD - College of Science and Health, DePaul University, Chicago, IL, United States. FAU - Wilhelm, Kaitlin AU - Wilhelm K AD - College of Nursing, Rush University, Chicago, IL, United States. FAU - Yeager, Charleen AU - Yeager C AD - College of Nursing, Rush University, Chicago, IL, United States. FAU - Reed, Monique AU - Reed M AD - College of Nursing, Rush University, Chicago, IL, United States. LA - eng GR - R01 DK132698/DK/NIDDK NIH HHS/United States PT - Journal Article DEP - 20251210 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - *Black or African American/psychology/statistics & numerical data MH - *Community Participation MH - *Cultural Competency MH - *Mothers/psychology MH - Obesity/prevention & control MH - *Patient Selection PMC - PMC12728040 OTO - NOTNLM OT - Black Girls OT - adolescent females OT - culture OT - mother-daughter dyads OT - obesity prevention OT - race-conscious OT - responsive recruitment COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/26 07:40 MHDA- 2025/12/26 07:41 PMCR- 2025/12/10 CRDT- 2025/12/26 04:35 PHST- 2025/05/24 00:00 [received] PHST- 2025/11/10 00:00 [revised] PHST- 2025/11/24 00:00 [accepted] PHST- 2025/12/26 07:41 [medline] PHST- 2025/12/26 07:40 [pubmed] PHST- 2025/12/26 04:35 [entrez] PHST- 2025/12/10 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1634312 [doi] PST - epublish SO - Front Public Health. 2025 Dec 10;13:1634312. doi: 10.3389/fpubh.2025.1634312. eCollection 2025. PMID- 41450133 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260915 IS - 1550-509X (Electronic) IS - 0885-9701 (Linking) VI - 41 IP - 5 DP - 2026 Sep-Oct 01 TI - Monitoring Adolescent Sport-Related Concussion Recovery Using Consumer-Grade Wearables: A Pilot Study. PG - e476-e485 LID - 10.1097/HTR.0000000000001143 [doi] AB - OBJECTIVE: To evaluate whether consumer-grade wearable devices (CGWDs) can detect physiological differences between adolescent athletes recovering from sport-related concussion (SRC) versus musculoskeletal (MSK) injury, and to examine whether wearable-derived physiological markers are associated with symptom burden during the acute post-injury phase. SETTING: Outpatient sports medicine clinic at a pediatric academic medical center. PARTICIPANTS: High school student-athletes aged 14-18 years were eligible if they presented within 10 days of SRC or acute, nonsurgical MSK injury and had internet access and willingness to comply with study procedures. Thirty-eight participants were enrolled; four were excluded due to protocol deviations. The final analytic sample included 34 participants (SRC: n = 17; MSK: n = 17). DESIGN: Prospective observational cohort study conducted from September 2021 to April 2022. All participants were issued a Fitbit Sense to passively monitor sleep, activity, and heart rate for up to 6 weeks post-injury. No randomization or blinding occurred, as this was an observational study. MAIN MEASURES: The primary outcome was group differences in CGWD-derived physiological metrics (sleep patterns and architecture, physical activity, heart rate) across 3 post-enrollment time intervals (Days 1-14, 15-28, 29-42). Secondary outcomes included correlations between physiological data and symptom burden based on the Post-Concussion Symptom Inventory, Second Edition (PCSI-2). RESULTS: Compared to MSK peers, participants with SRC showed significantly more light sleep, more nocturnal wake time, and lower daily step counts during the first 4 weeks post-injury ( P <.0038). No significant differences were observed in REM sleep, deep sleep, or heart rate. In SRC participants, greater nocturnal wake time and lower resting heart rate were modestly associated with higher cognitive symptom ratings; emotional symptoms were modestly associated with step counts. No adverse events occurred. CONCLUSIONS: CGWDs may capture recovery-specific physiological disruptions in adolescent SRC, particularly in sleep and physical activity. These findings support the potential for wearable technology to inform individualized, objective approaches to concussion monitoring in clinical practice. CI - Copyright (c) 2025 Wolters Kluwer Health, LLC. All rights reserved. FAU - Ransom, Danielle M AU - Ransom DM AD - Author Affiliations: Center for Behavioral Health, Johns Hopkins All Children's Hospital, St. Petersburg, Florida (Dr Ransom); Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland (Dr Ransom); Center for Pediatric Data Science & Analytic Methodology, Johns Hopkins All Children's Hospital, St. Petersburg, Florida (Drs Tudor, Rehman, Ahumada); Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland (Drs Tudor, Rehman, Ahumada); Division of Sports Medicine, Johns Hopkins All Children's Hospital, St. Petersburg, Florida (Drs Irani, Mularoni); Brain Injury Clinical Research Center, Kennedy Krieger Institute, Baltimore, Marlyland (Drs Suskauer, Svingos); Department of Physical Medicine & Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, Maryland (Drs Suskauer, Svingos); and Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland (Drs Suskauer, Mularoni). FAU - Tudor, Brant H AU - Tudor BH FAU - Irani, Sarah A AU - Irani SA FAU - Rehman, Mohamed A AU - Rehman MA FAU - Suskauer, Stacy J AU - Suskauer SJ FAU - Svingos, Adrian M AU - Svingos AM FAU - Ahumada, Luis M AU - Ahumada LM FAU - Mularoni, P Patrick AU - Mularoni PP LA - eng PT - Journal Article PT - Observational Study DEP - 20251216 PL - United States TA - J Head Trauma Rehabil JT - The Journal of head trauma rehabilitation JID - 8702552 SB - IM MH - Humans MH - Adolescent MH - Pilot Projects MH - Female MH - Male MH - *Wearable Electronic Devices MH - *Athletic Injuries/physiopathology/rehabilitation MH - Prospective Studies MH - *Brain Concussion/physiopathology/rehabilitation/diagnosis MH - Recovery of Function MH - Heart Rate/physiology MH - Sleep/physiology OTO - NOTNLM OT - adolescent OT - brain concussion OT - feasibility studies OT - heart rate/physiology OT - monitoring OT - motor activity/physiology OT - physiologic OT - recovery of function OT - sleep wake disorders/physiopathology OT - sports injuries OT - wearable electronic devices COIS- No conflicts of interest are declared. This work was supported in part by a research grant from the Kart 4 Kids Concussion Initiative through the Johns Hopkins All Children's Foundation. EDAT- 2025/12/26 07:40 MHDA- 2026/09/03 23:36 CRDT- 2025/12/26 03:42 PHST- 2025/08/11 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/09/03 23:36 [medline] PHST- 2025/12/26 07:40 [pubmed] PHST- 2025/12/26 03:42 [entrez] AID - 00001199-990000000-00343 [pii] AID - 10.1097/HTR.0000000000001143 [doi] PST - ppublish SO - J Head Trauma Rehabil. 2026 Sep-Oct 01;41(5):e476-e485. doi: 10.1097/HTR.0000000000001143. Epub 2025 Dec 16. PMID- 41450131 OWN - NLM STAT- Publisher LR - 20251226 IS - 1532-530X (Electronic) IS - 1064-0266 (Linking) DP - 2025 Dec 26 TI - How do adult inpatients with ARFID or AN-R compare on self-report eating disorder assessments? PG - 1-14 LID - 10.1080/10640266.2025.2608345 [doi] AB - The Pica, ARFID, and Rumination Disorder ARFID Questionnaire (PARDI-AR-Q) and the Eating Disorders in Youth Questionnaire (EDY-Q) were developed to assess avoidant/restrictive food intake disorder (ARFID), but research is ongoing regarding their discriminant validity. This study examined scores of adult inpatients with ARFID or anorexia nervosa, restricting type (AN-R) on the PARDI-AR-Q, EDY-Q, and Eating Disorder Examination Questionnaire (EDE-Q) at admission to a medical stabilization unit for severe eating disorders. Response differences between 78 adult inpatients with ARFID or AN-R were analyzed using a two-sample t-test or Fisher's exact test. Sensitivity and specificity of self-report measures were examined using receiver operating characteristic curves. Patients with AN-R had significantly higher severity of impact and lower concern about aversive consequences scores than patients with ARFID on the PARDI-AR-Q (p < .001), with no significant differences on sensory-based avoidance or lack of interest or EDY-Q total score. Patients with AN-R scored significantly higher on all domains of the EDE-Q (p's < .001) and the EDE-Q subscales had better discrimination than ARFID measures. This study provides further evidence of the need for assessments that can distinguish ARFID from AN, and may also highlight the need for future research on the nosological accuracy of differentiating these disorders. FAU - Manwaring, Jamie L AU - Manwaring JL AUID- ORCID: 0000-0002-7798-0612 AD - ACUTE Center for Eating Disorders and Severe Malnutrition at Denver Health, Denver, CO, USA. AD - Department of Medicine, University of Colorado School of Medicine, Denver, CO, USA. AD - Eating Recovery Center and Pathlight Behavioral Health Centers, Denver, CO, USA. FAU - Cass, Kamila AU - Cass K AD - ACUTE Center for Eating Disorders and Severe Malnutrition at Denver Health, Denver, CO, USA. AD - Department of Medicine, University of Colorado School of Medicine, Denver, CO, USA. FAU - Prostko, Sara AU - Prostko S AD - Department of Psychology, Florida State University, Tallahassee, FL, USA. FAU - Stein, Amy Buros AU - Stein AB AD - Center for Health Systems Research, Denver Health and Hospitals, Denver, CO, USA. FAU - Mehler, Philip S AU - Mehler PS AD - ACUTE Center for Eating Disorders and Severe Malnutrition at Denver Health, Denver, CO, USA. AD - Department of Medicine, University of Colorado School of Medicine, Denver, CO, USA. AD - Eating Recovery Center and Pathlight Behavioral Health Centers, Denver, CO, USA. FAU - Joiner, Thomas AU - Joiner T AUID- ORCID: 0000-0001-6798-9085 AD - Department of Psychology, Florida State University, Tallahassee, FL, USA. FAU - Rienecke, Renee D AU - Rienecke RD AD - Eating Recovery Center and Pathlight Behavioral Health Centers, Denver, CO, USA. AD - Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL, USA. LA - eng PT - Journal Article DEP - 20251226 PL - United States TA - Eat Disord JT - Eating disorders JID - 9315161 SB - IM EDAT- 2025/12/26 07:40 MHDA- 2025/12/26 07:40 CRDT- 2025/12/26 03:42 PHST- 2025/12/26 07:40 [medline] PHST- 2025/12/26 07:40 [pubmed] PHST- 2025/12/26 03:42 [entrez] AID - 10.1080/10640266.2025.2608345 [doi] PST - aheadofprint SO - Eat Disord. 2025 Dec 26:1-14. doi: 10.1080/10640266.2025.2608345. PMID- 41449688 OWN - NLM STAT- MEDLINE DCOM- 20260331 LR - 20260813 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2025 Dec 26 TI - Influence of lifestyle and eating behaviours on Mediterranean diet adherence in preschoolers from southern Spain. PG - e56 LID - 10.1017/S1368980025101742 [doi] LID - e56 AB - OBJECTIVE: The present study examined the association of screen and sleep time, physical fitness and eating behaviour with Mediterranean diet (MD) adherence in a sample of preschoolers from Granada, Spain. DESIGN: A cross-sectional, non-randomised design was employed. A multilinear regression model with backward elimination was used for analysis. SETTING: Variables included age, screen time, hours of nightly sleep, physical fitness, food approach and food avoidance. The developed model met assumptions of multiple regression in terms of linearity, homoscedasticity, normality, independence and non-multicollinearity. PARTICIPANTS: Data were collected from 653 of the 2250 three-to-six-year-old children attending the eighteen schools invited to take part in the present study. Data on children's behaviours were parent-reported using validated questionnaires. RESULTS: Better sleep time and lower screen time and food avoidance were found to be predictive of MD adherence. These variables explained 15 % of the variance in preschoolers' MD adherence. CONCLUSIONS: The present study suggests that sleep and screen time and food avoidance are important components to consider when targeting improvements in MD adherence in preschoolers. Future research should explore the way in which parental health behaviours influence their children's health habits in order to better understand the outcomes. FAU - Villodres, Gracia Cristina AU - Villodres GC AUID- ORCID: 0000-0002-8304-5719 AD - Department of Didactics of Corporal Expression, Faculty of Education, https://ror.org/04njjy449University of Granada, Granada, Spain. FAU - Padial-Ruz, Rosario AU - Padial-Ruz R AD - Department of Didactics of Corporal Expression, Faculty of Education, https://ror.org/04njjy449University of Granada, Granada, Spain. FAU - Perez-Diaz, Juan Jose AU - Perez-Diaz JJ AD - Department of Physical Education and Sports, Faculty of Sports Sciences, University of Granada, Granada, Spain. FAU - Muros, Jose Joaquin AU - Muros JJ AUID- ORCID: 0000-0001-7573-0399 AD - Department of Didactics of Corporal Expression, Faculty of Education, https://ror.org/04njjy449University of Granada, Granada, Spain. LA - eng PT - Journal Article DEP - 20251226 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - *Diet, Mediterranean/statistics & numerical data MH - Spain MH - Male MH - Female MH - Cross-Sectional Studies MH - Child, Preschool MH - *Feeding Behavior MH - Sleep MH - Child MH - *Life Style MH - Screen Time MH - Surveys and Questionnaires MH - *Child Behavior MH - *Health Behavior PMC - PMC13112296 OTO - NOTNLM OT - Childhood OT - Healthy behaviours OT - Quality diet OT - Sedentary behaviours COIS- There are no conflicts of interest. EDAT- 2025/12/26 07:40 MHDA- 2026/03/31 06:59 PMCR- 2025/12/26 CRDT- 2025/12/26 01:02 PHST- 2026/03/31 06:59 [medline] PHST- 2025/12/26 07:40 [pubmed] PHST- 2025/12/26 01:02 [entrez] PHST- 2025/12/26 00:00 [pmc-release] AID - S1368980025101742 [pii] AID - 10.1017/S1368980025101742 [doi] PST - epublish SO - Public Health Nutr. 2025 Dec 26;29(1):e56. doi: 10.1017/S1368980025101742. PMID- 41449562 OWN - NLM STAT- MEDLINE DCOM- 20251226 LR - 20260711 IS - 1369-7625 (Electronic) IS - 1369-6513 (Print) IS - 1369-6513 (Linking) VI - 29 IP - 1 DP - 2026 Feb TI - Exploring the Views of Children With Cerebral Palsy, Their Parents and Physiotherapists on Participating in a Feasibility Randomised Controlled Trial Testing an Exergaming Device: A Qualitative Study. PG - e70533 LID - 10.1111/hex.70533 [doi] LID - e70533 AB - BACKGROUND: This study aimed to understand the experiences and views of children with cerebral palsy, their parents and physiotherapists participating in the ACCEPT feasibility randomised controlled trial, which explored a 10-week physiotherapy intervention using an interactive gaming training device. DESIGN: Qualitative methods included semi-structured interviews, e-diary and photographs. Nine parent-child dyads and three physiotherapists participated. Children were aged between 7 and 16 years; four had co-existing additional needs. Interviews were transcribed. Reflexive thematic analysis was used. RESULTS: Five themes covered the breadth of participants' experiences: (1) Fitting in therapy; (2) Motivation; (3) New opportunities; (4) Physiotherapists out of their comfort zone; and (5) Altruism and challenges. Parents spoke of the challenge of finding time to engage their children in therapeutic exercise. Several children talked about trial-related procedures (e.g. removal of adhesive markers) that they disliked. Physiotherapists, children and parents supported the gaming aspect of the device to improve motivation to exercise. CONCLUSIONS: Overall, the intervention and measures were acceptable to children and parents. Parents were willing to accommodate the device for 10 weeks and children found the gaming aspect both motivating and enjoyable. Physiotherapists required more support to solve technical problems with the device. A full trial evaluating the device requires additional technical support from the supplier and experienced 'champion' users. Exercise trainers that encompass gaming may increase motivation and adherence to therapeutic programmes. PATIENT OR PUBLIC CONTRIBUTION: Children, families and care givers were included in the study design. They helped to produce participant facing documents including the e-diary and interview topic guides. The study steering committee included several parents and one teenager, and provided governance and oversight of the project. CI - (c) 2025 The Author(s). Health Expectations published by John Wiley & Sons Ltd. FAU - Rapson, Rachel AU - Rapson R AUID- ORCID: 0000-0001-8265-5358 AD - Peninsula Allied Health Centre, University of Plymouth, Plymouth, UK. AD - Children and Family Health Devon, Torbay and South Devon NHS Foundation Trust, Barnstaple, UK. FAU - Latour, Jos M AU - Latour JM AUID- ORCID: 0000-0002-8087-6461 AD - school of Nursing and Midwifery, Faculty of Health, University of Plymouth, Plymouth, UK. FAU - Marsden, Jonathan AU - Marsden J AUID- ORCID: 0000-0002-2037-4902 AD - Peninsula Allied Health Centre, University of Plymouth, Plymouth, UK. FAU - Carter, Bernie AU - Carter B AUID- ORCID: 0000-0001-5226-9878 AD - Faculty of Health, Social Care and Medicine, Edgehill University, Liverpool, UK. LA - eng GR - ICA-CDRF-2017-03-041/National Institute for Health and Care Research/ PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't PL - England TA - Health Expect JT - Health expectations : an international journal of public participation in health care and health policy JID - 9815926 SB - IM MH - Humans MH - *Cerebral Palsy/psychology/rehabilitation/therapy MH - Child MH - *Parents/psychology MH - Adolescent MH - Qualitative Research MH - Female MH - Male MH - *Physical Therapists/psychology MH - Feasibility Studies MH - *Video Games/psychology MH - Motivation MH - Interviews as Topic MH - *Exercise Therapy/methods/instrumentation/psychology PMC - PMC12740999 OTO - NOTNLM OT - cerebral palsy OT - children OT - exercise device OT - exergaming OT - feasibility OT - gaming OT - physiotherapy COIS- The authors declare no conflicts of interest. EDAT- 2025/12/26 00:32 MHDA- 2025/12/26 07:40 PMCR- 2025/12/25 CRDT- 2025/12/25 23:53 PHST- 2025/06/13 00:00 [revised] PHST- 2025/03/07 00:00 [received] PHST- 2025/12/08 00:00 [accepted] PHST- 2025/12/26 07:40 [medline] PHST- 2025/12/26 00:32 [pubmed] PHST- 2025/12/25 23:53 [entrez] PHST- 2025/12/25 00:00 [pmc-release] AID - HEX70533 [pii] AID - 10.1111/hex.70533 [doi] PST - ppublish SO - Health Expect. 2026 Feb;29(1):e70533. doi: 10.1111/hex.70533. PMID- 41449411 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260626 IS - 1472-6955 (Print) IS - 1472-6955 (Electronic) IS - 1472-6955 (Linking) VI - 25 IP - 1 DP - 2025 Dec 26 TI - Turkish neonatal nurses' knowledge regarding the enteral feeding in preterm infants: a descriptive, cross-sectional study. PG - 100 LID - 10.1186/s12912-025-04213-3 [doi] LID - 100 AB - BACKGROUND: Neonatal nurses play a key role in the safe and effective enteral feeding of preterm infants, but their knowledge and practices in this specific area remain largely unexamined. This study sought to evaluate neonatal nurses' knowledge levels and practices concerning enteral feeding in preterm infants. METHODS: A total of 300 neonatal intensive care nurses working in 8 hospitals in Istanbul, Turkiye were included in this descriptive cross-sectional study. Data were collected using a sociodemographic information and enteral feeding practices form and an enteral feeding knowledge questionnaire. The 40-item enteral feeding knowledge questionnaire yields a total score ranging from 0 to 100, with higher scores indicating a higher knowledge level. Based on a 6-expert panel review, the content validity index (CVI) of the questionnaire was 0.94. RESULTS: The mean knowledge score was 67.12 out of 100 (SD, 8.83; range, 45-85). Older age (P = .001), longer NICU experience (P = .003), higher education level (P = .043), and having NICU nursing certification (P = .001) were associated with significantly higher knowledge levels. Correct response rates were particularly low for items about the selection of appropriate catheter size in preterm infants with extremely low birth weight, infant positioning during catheter insertion and feeding, the necessity of verifying catheter placement before each feeding, the method used to confirm correct catheter placement, feeding flow rate, assessment of gastric residuals, and maintenance of asepsis. None of the participating nurses' NICUs used a standard protocol for enteral feeding in preterm infants. CONCLUSION: The research findings point to the necessity of supporting nurses with evidence-based information on enteral feeding practices, ensuring the standardization of clinical practices, and managing enteral feeding in accordance with current guidelines. FAU - Gozen, Duygu AU - Gozen D AD - Koc University School of Nursing, Istanbul, Turkiye. dugozen@ku.edu.tr. FAU - Aykanat Gi̇rgi̇n, Burcu AU - Aykanat Gi̇rgi̇n B AD - Hamidiye Faculty of Nursing, Saglik Bilimleri University, Istanbul, Turkiye. FAU - Carikci, Fatma AU - Carikci F AD - Vocational School of Health Sciences, Yeni Yuzyil University, Istanbul, Turkiye. FAU - Temi̇zsoy, Ebru AU - Temi̇zsoy E AD - Faculty of Health Sciences, Istanbul Bilgi University, Istanbul, Turkiye. LA - eng PT - Journal Article DEP - 20251226 PL - England TA - BMC Nurs JT - BMC nursing JID - 101088683 PMC - PMC12853849 OTO - NOTNLM OT - Enteral OT - Feeding OT - Health knowledge OT - Neonatal intensive care OT - Nurses COIS- Declarations. Ethics approval and consent to participate: This study has been approved by the Ethics Committee of Health Sciences University in Istanbul, Turkiye (Ethical Review Number: 224.364.IRB3.151). The consent that was obtained from all of the participants was informed. This study was conducted in accordance with the principles outlined in the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/26 00:32 MHDA- 2025/12/26 00:33 PMCR- 2025/12/26 CRDT- 2025/12/25 23:15 PHST- 2025/08/12 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2025/12/26 00:33 [medline] PHST- 2025/12/26 00:32 [pubmed] PHST- 2025/12/25 23:15 [entrez] PHST- 2025/12/26 00:00 [pmc-release] AID - 10.1186/s12912-025-04213-3 [pii] AID - 4213 [pii] AID - 10.1186/s12912-025-04213-3 [doi] PST - epublish SO - BMC Nurs. 2025 Dec 26;25(1):100. doi: 10.1186/s12912-025-04213-3. PMID- 41449351 OWN - NLM STAT- MEDLINE DCOM- 20260129 LR - 20260602 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 26 IP - 1 DP - 2025 Dec 25 TI - Associations between appetite loss and psychopathology as well as gender differences in adolescents with major depressive disorders. PG - 89 LID - 10.1186/s12888-025-07718-y [doi] LID - 89 AB - BACKGROUND: Appetite loss is frequent in patients with major depressive disorders (MDD). However, research on the association between appetite loss and psychopathology symptoms in adolescents with MDD remains limited, particularly regarding gender differences. Therefore, this study aimed to explore these associations and potential gender differences. METHODS: A cross-sectional study carried out between January to December 2021 in eight hospitals, recruiting 364 adolescents with MDD. It utilized the Hamilton Depression Scale (HAMD), the Positive and Negative Suicide Ideation Scale for Adolescents (PANSI), the Chinese version of the Epworth Sleepiness Scale (ESS), the Insomnia Severity Index (ISI), and the Chinese version of the Internet Addiction Test (IAT) to assess patients' depressive severity, suicidal ideation, sleepiness, insomnia, and internet addiction, respectively. Logistic regression was employed to examine the independent factors with an impact on appetite loss. RESULTS: The prevalence of appetite loss was 69.2% in adolescents with MDD and 74.7% in female patients. Regression results indicated that appetite loss was independently correlated with Gender (OR = 0.559, 95% CI = 0.331 ~ 0.944, p = 0.029), BMI (OR = 0.925, 95% CI = 0.876 ~ 0.977, p = 0.005), HAMD score (OR = 1.080, 95% CI = 1.041 ~ 1.120, p < 0.001) and ISI score (OR = 1.073, 95% CI = 1.024 ~ 1.124, p = 0.003). When discussing gender differences, it was found that female patients were independently associated with BMI, HAMD score and ISI score, while male patients were only independently associated with HAMD score. Finally, the receiver operating characteristic (ROC) curve results showed that combining Gender, BMI, HAMD score, and ISI score predicted appetite loss well (AUC = 0.746). In female patients, the combined prediction of BMI, HAMD score, ESS score, and ISI score demonstrated predictive value for appetite loss (AUC = 0.732). In male patients, the HAMD score served as an effective predictor (AUC = 0.713). CONCLUSION: Adolescents with MDD, particularly females, faced a heightened risk of appetite loss. Additionally, appetite loss was significantly associated with multiple clinical symptoms, and these associations showed certain gender differences. CLINICAL TRIAL NUMBER: Not applicable. CI - (c) 2025. The Author(s). FAU - Xue, Jinyue AU - Xue J AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, 64 Chaohu North Road, Hefei, Anhui Province, 238000, China. AD - Department of Psychiatry, School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, Anhui Province, 230032, China. FAU - Liu, Lewei AU - Liu L AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, 64 Chaohu North Road, Hefei, Anhui Province, 238000, China. FAU - Shang, Jingwen AU - Shang J AD - Department of Psychiatry, School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, Anhui Province, 230032, China. FAU - Feng, Yachen AU - Feng Y AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, 64 Chaohu North Road, Hefei, Anhui Province, 238000, China. FAU - Sun, Xianlin AU - Sun X AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, 64 Chaohu North Road, Hefei, Anhui Province, 238000, China. FAU - Wang, Jiawei AU - Wang J AD - Department of Psychiatry, Bozhou People's Hospital, Bozhou, Anhui, 236800, China. FAU - Chen, Changhao AU - Chen C AD - Department of Psychiatry, Suzhou Second People's Hospital, Suzhou, Anhui Province, 234099, China. FAU - Liu, Zhiwei AU - Liu Z AD - Department of Psychiatry, Fuyang Third People's Hospital, Fuyang, Anhui Province, 236044, China. FAU - Geng, Feng AU - Geng F AD - Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, 230000, China. FAU - Mo, Daming AU - Mo D AD - Department of Psychiatry, Anhui Province Second People's Hospital, Hefei, Anhui Province, 230041, China. FAU - Luo, Xiangfen AU - Luo X AD - Department of Psychiatry, Anhui Province Second People's Hospital, Hefei, Anhui Province, 230041, China. FAU - Wen, Xiangwang AU - Wen X AD - Department of Psychiatry, Ma'anshan Fourth People's Hospital, Ma'anshan, Anhui Province, 243031, China. FAU - Xia, Lei AU - Xia L AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, 64 Chaohu North Road, Hefei, Anhui Province, 238000, China. xialei@ahmu.edu.cn. FAU - Liu, Huanzhong AU - Liu H AD - Department of Psychiatry, The Fourth Affiliated Hospital of Anhui Medical University, 64 Chaohu North Road, Hefei, Anhui Province, 238000, China. huanzhongliu@ahmu.edu.cn. AD - Department of Psychiatry, School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, Anhui Province, 230032, China. huanzhongliu@ahmu.edu.cn. LA - eng GR - No. 82401798/the National Natural Science Foundation of China/ GR - No. 2022zhyx-B01/the Research Fund Project of Anhui Translational Research Institute/ GR - No. 2024AH050681/the Scientifc Research Project of Anhui Higher Education Institutions/ PT - Journal Article DEP - 20251225 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 SB - IM MH - Humans MH - Male MH - Female MH - Adolescent MH - *Major Depressive Disorder/psychology/epidemiology/complications/physiopathology MH - Cross-Sectional Studies MH - Sex Factors MH - Suicidal Ideation MH - Sleep Initiation and Maintenance Disorders/epidemiology MH - Severity of Illness Index MH - China/epidemiology MH - Internet Addiction Disorder/epidemiology PMC - PMC12849411 OTO - NOTNLM OT - Adolescents OT - Appetite loss OT - Gender differences OT - Major depressive disorder OT - Psychopathology COIS- Declarations. Ethical approval: This study was approved by the Ethics Committee of the Fourth Affiliated Hospital of Anhui Medical University (202009-kyxm-04). Furthermore, all procedures conformed to the ethical standards of the 2013 version of the Helsinki Declaration ( https://www.wma.net/policies-post/wma-declaration-of-helsinki/ ). Written informed consent was obtained from all participants and their legal guardians after they were fully informed about the study. Competing interests: The authors declare no competing interests. EDAT- 2025/12/26 00:32 MHDA- 2026/01/29 07:34 PMCR- 2025/12/25 CRDT- 2025/12/25 23:13 PHST- 2025/08/20 00:00 [received] PHST- 2025/12/15 00:00 [accepted] PHST- 2026/01/29 07:34 [medline] PHST- 2025/12/26 00:32 [pubmed] PHST- 2025/12/25 23:13 [entrez] PHST- 2025/12/25 00:00 [pmc-release] AID - 10.1186/s12888-025-07718-y [pii] AID - 7718 [pii] AID - 10.1186/s12888-025-07718-y [doi] PST - epublish SO - BMC Psychiatry. 2025 Dec 25;26(1):89. doi: 10.1186/s12888-025-07718-y. PMID- 41448742 OWN - NLM STAT- MEDLINE DCOM- 20251225 LR - 20251228 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 9 IP - 1 DP - 2025 Dec 24 TI - Diagnostic accuracy of newborn foot length measurement in identifying low birth weight and preterm infants in Sidama Region, Ethiopia. LID - 10.1136/bmjpo-2025-003374 [doi] LID - e003374 AB - BACKGROUND: Low birth weight (LBW) and preterm birth significantly contribute to increased risks of neonatal mortality, particularly in sub-Saharan Africa. Early identification of and timely intervention for these vulnerable infants remains challenging. Simple anthropometric measurements, such as foot length (FL), have emerged as potential alternatives to identify small and vulnerable newborns. This study aims to assess the accuracy of FL as a screening tool to identify LBW and preterm babies and to establish appropriate cut-off points for the local context. METHODS: A facility-based cross-sectional study was conducted at Hawassa University Comprehensive Specialised Hospital and Bushulo Mother, Newborn and Child Health Specialty Centre and Primary healthcare from 15 May 2024 to 6 July 2024; 396 mother-newborn dyads were included using a consecutive sampling technique. Data were collected through interview, medical record review and FL measurement using digital calliper. Birth weight was measured using calibrated digital weight scales. Descriptive statistics, correlation analysis and receiver operating characteristic (ROC) curves were used to assess the distribution of measured characteristics and determine optimal FL cut-off points for identifying LBW and preterm babies. RESULTS: The study included 61 (15.4%) LBW and 48 (12.3%) preterm babies. FL showed a strong correlation with birth weight (r=0.79) and moderate correlation with gestational age (r=0.62). The optimal cut-off point for identifying LBW babies was 70.65 mm, yielding 93.4% sensitivity, 91.6% specificity and an area under receiver operator curve (AUC) of 0.97 (95% CI: 0.95 to 0.98). For preterm babies, the optimal cut-off was 69.95 mm, with 76.7% sensitivity, 91.1% specificity and an AUC of 0.91 (95% CI: 0.86 to 0.96). CONCLUSION: FL has demonstrated excellent diagnostic accuracy to identify LBW and preterm newborns. Optimal accuracy of identifying LBW and preterm babies in similar populations can be achieved at 70.65 and 69.95 mm cut-off points, respectively. In designing FL-based screening tools, appropriate cut-off points for the required level of accuracy should be considered. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Belay, Fitsum Weldegebriel AU - Belay FW AUID- ORCID: 0000-0002-9671-7422 AD - Department of Pediatrics and Child Health, Hawassa University College of Medicine and Health Sciences, Hawassa, Ethiopia fitsedememmj@gmail.com. FAU - Bekele, Fanuel Belayneh AU - Bekele FB AUID- ORCID: 0000-0001-7021-0773 AD - Public Health, Hawassa University, Hawassa, Ethiopia. FAU - Alemayehu, Akalewold AU - Alemayehu A AUID- ORCID: 0000-0002-6448-6092 AD - Hawassa University College of Medicine and Health Sciences, Hawassa, Ethiopia. FAU - Fikre, Rekiku AU - Fikre R AUID- ORCID: 0000-0003-1324-1631 AD - Midwifery, Hawassa University, Hawassa, Ethiopia. FAU - Clarke, Andrew AU - Clarke A AUID- ORCID: 0000-0003-3127-5309 AD - Save The Children UK, London, UK. AD - Lancaster University, Lancaster, UK. FAU - Williams, Sarah AU - Williams S AD - Save The Children UK, London, UK. FAU - Richards, Hannah AU - Richards H AD - Save the Children International, London, UK. FAU - Chanyalew Kassa, Yohannes AU - Chanyalew Kassa Y AUID- ORCID: 0009-0009-9644-0839 AD - Health and Nutrition, Save the Children Ethiopia Country Office, Addis Ababa, Ethiopia. LA - eng PT - Journal Article DEP - 20251224 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Infant, Newborn MH - *Infant, Low Birth Weight MH - Ethiopia MH - Cross-Sectional Studies MH - Female MH - *Infant, Premature MH - Male MH - *Foot/anatomy & histology MH - *Anthropometry/methods MH - Adult MH - ROC Curve MH - *Neonatal Screening/methods PMC - PMC12742128 OTO - NOTNLM OT - Developing Countries OT - Health Policy OT - Neonatology COIS- Competing interests: None declared. EDAT- 2025/12/26 00:32 MHDA- 2025/12/26 00:33 PMCR- 2025/12/24 CRDT- 2025/12/25 20:55 PHST- 2025/01/28 00:00 [received] PHST- 2025/11/05 00:00 [accepted] PHST- 2025/12/26 00:33 [medline] PHST- 2025/12/26 00:32 [pubmed] PHST- 2025/12/25 20:55 [entrez] PHST- 2025/12/24 00:00 [pmc-release] AID - 10.1136/bmjpo-2025-003374 [pii] AID - bmjpo-2025-003374 [pii] AID - 10.1136/bmjpo-2025-003374 [doi] PST - epublish SO - BMJ Paediatr Open. 2025 Dec 24;9(1):e003374. doi: 10.1136/bmjpo-2025-003374. PMID- 41448617 OWN - NLM STAT- In-Process DCOM- 20260130 LR - 20260623 IS - 2508-7576 (Electronic) IS - 2508-6235 (Print) IS - 2508-6235 (Linking) VI - 35 IP - 1 DP - 2026 Jan 30 TI - Diagnostic Accuracy of the Triglyceride-Glucose Derived Indices in Detecting Metabolic Syndrome in Pediatric Patients. PG - 86-98 LID - 10.7570/jomes25002 [doi] AB - BACKGROUND: Given the challenges associated with direct insulin measurements, several surrogate markers combining both anthropometric data and laboratory tests (such as glucose and lipid levels) have been developed. This study aims to assess the diagnostic accuracy of the following indices: triglyceride-glucose (TyG) index, TyG index adjusted for body mass index (TyG-BMI), TyG index adjusted for waist circumference (TyG-WC), and TyG index adjusted for waist-to-height ratio (TyG-WHtR), for detecting metabolic syndrome (MetS) in the pediatric population, in comparison with conventional parameters. METHODS: We retrospectively analyzed data from 746 children and adolescents (372 female/374 male) categorized into groups based on BMI z-score. Insulin resistance (IR) surrogates were calculated as: homeostasis model assessment of insulin resistance (HOMA-IR), TyG, TyG-BMI, TyG-WC, and TyG-WHtR. MetS was defined by the presence of at least three of the following components: BMI z-score >/=2 standard deviation and/or WC/height ratio >/=0.5; fasting blood glucose >100 mg/dL and/or pathological HOMA-IR; dyslipidemia; and hypertension. RESULTS: The overall prevalence of MetS was 15.01% (112/746), occurring exclusively in children with obesity or overweight (P=0.004). The third quartile (Q3) was identified as the optimal cut-off point for the TyG indices (TyG, 8.1; TyG-BMI, 231.54; TyG-WC, 734.03; and TyG-WHtR, 4.73). The areas under the receiver operating characteristic curves (AUCs) of TyG, TyG-BMI, TyG-WC, and TyG-WHtR were 0.801 (P<0.001), 0.840 (P<0.001), 0.832 (P<0.001), and 0.816 (P<0.001) respectively, comparable to the AUC of HOMA-IR, which was 0.866 (P<0.001). CONCLUSION: The TyG, TyG-BMI, TyG-WC, and TyG-WHtR indices demonstrated promising predictive value for MetS in children with overweight or obesity. These markers can effectively identify high-risk individuals and offer a cost-effective alternative to direct assessment of insulin sensitivity. FAU - Calcaterra, Valeria AU - Calcaterra V AUID- ORCID: 0000-0002-2137-5974 AD - Pediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, Pavia, Italy. AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. FAU - Labati, Lucia AU - Labati L AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. AD - Department of Biomedical and Clinical Science, University of Milan, Milan, Italy. FAU - Cordaro, Erika AU - Cordaro E AD - Pediatric and Adolescent Unit, Department of Internal Medicine, University of Pavia, Pavia, Italy. AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. FAU - Schneider, Laura AU - Schneider L AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. FAU - Rossi, Virginia AU - Rossi V AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. AD - Department of Biomedical and Clinical Science, University of Milan, Milan, Italy. FAU - Colombo, Alice AU - Colombo A AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. FAU - Turzi, Massimiliano AU - Turzi M AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. FAU - Fabiano, Valentina AU - Fabiano V AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. AD - Department of Biomedical and Clinical Science, University of Milan, Milan, Italy. FAU - Zuccotti, Gianvincenzo AU - Zuccotti G AD - Pediatric Department, Buzzi Children's Hospital, Milan, Italy. AD - Department of Biomedical and Clinical Science, University of Milan, Milan, Italy. LA - eng PT - Journal Article DEP - 20251226 PL - Korea (South) TA - J Obes Metab Syndr JT - Journal of obesity & metabolic syndrome JID - 101704724 PMC - PMC12884620 OTO - NOTNLM OT - Child OT - Insulin resistance OT - Metabolic syndrome OT - Pediatrics OT - Triglyceride-glucose index COIS- CONFLICTS OF INTEREST The authors declare no conflict of interest. EDAT- 2025/12/26 00:32 MHDA- 2025/12/26 00:33 PMCR- 2025/12/26 CRDT- 2025/12/25 20:12 PHST- 2025/01/14 00:00 [received] PHST- 2025/04/14 00:00 [revised] PHST- 2025/07/08 00:00 [accepted] PHST- 2025/12/26 00:33 [medline] PHST- 2025/12/26 00:32 [pubmed] PHST- 2025/12/25 20:12 [entrez] PHST- 2025/12/26 00:00 [pmc-release] AID - jomes25002 [pii] AID - jomes-35-1-86 [pii] AID - 10.7570/jomes25002 [doi] PST - ppublish SO - J Obes Metab Syndr. 2026 Jan 30;35(1):86-98. doi: 10.7570/jomes25002. Epub 2025 Dec 26. PMID- 41447747 OWN - NLM STAT- MEDLINE DCOM- 20260204 LR - 20260730 IS - 1872-6283 (Electronic) IS - 0379-0738 (Linking) VI - 380 DP - 2026 Feb TI - Age assessment using the second molar maturation index (I(2M)): A systematic review. PG - 112792 LID - S0379-0738(25)00436-0 [pii] LID - 10.1016/j.forsciint.2025.112792 [doi] AB - Age estimation plays a crucial role in forensic sciences, being necessary for deceased and living individuals. In adolescents, it is often used to estimate whether an individual is above or below legal age thresholds, which vary across countries. In 2018, Cameriere et al. introduced the Second Molar Maturation Index (I(2M)), a method based on measuring apical openings and tooth height of the second molar to estimate whether an individual is older or younger than 14 or 16 years. Since then, some studies have sought to validate this method, with varying outcomes. This systematic review aimed to assess the applicability of the I(2M) method for estimating age thresholds of 12, 14, 15, and 16 years in forensic contexts. A systematic search was conducted in six databases (PubMed/MEDLINE, Embase, Scopus, Web of Science, LILACS, and SciELO), using keywords in Portuguese, Spanish, and English. Studies were selected based on predefined inclusion and exclusion criteria. The methodological quality and risk of bias were assessed. Seven eligible studies were identified, all using orthopantomographs of individuals aged 7-22 years. Validations were performed in seven countries: Brazil, Chile, China, Croatia, India, Portugal, and Turkey. All included studies showed a low risk of bias. The findings indicate that the I(2M) method is applicable for estimating age thresholds of 12, 14, 15, and 16 years in forensic practice, with satisfactory results across diverse populations. However, further primary research is necessary to strengthen the evidence base and improve the method's reliability. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - de Araujo Oliveira, Clarice AU - de Araujo Oliveira C AD - Department of Pathology and Legal Medicine, Ribeirao Preto Medical School, USP - University of Sao Paulo, Ribeirao Preto, Brazil. FAU - Furtado, Beatriz Alves AU - Furtado BA AD - Department of Pathology and Legal Medicine, Ribeirao Preto Medical School, USP - University of Sao Paulo, Ribeirao Preto, Brazil. FAU - Pinto, Paulo Henrique Viana AU - Pinto PHV AD - Department of Pathology and Legal Medicine, Ribeirao Preto Medical School, USP - University of Sao Paulo, Ribeirao Preto, Brazil; Forensic Odontologist at Bahia State Scientific Police, Camacari, Bahia, Brazil. FAU - da Silva, Ricardo Henrique Alves AU - da Silva RHA AD - Department of Stomatology, Public Health and Forensic Odontology, Ribeirao Preto School of Dentistry, USP - University of Sao Paulo, Ribeirao Preto, Brazil. Electronic address: ricardohenrique@usp.br. LA - eng PT - Journal Article PT - Systematic Review DEP - 20251223 PL - Ireland TA - Forensic Sci Int JT - Forensic science international JID - 7902034 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - *Molar/growth & development/diagnostic imaging MH - Adolescent MH - Radiography, Panoramic MH - Child MH - Forensic Dentistry MH - *Tooth Apex/growth & development/diagnostic imaging OTO - NOTNLM OT - Age determination by teeth OT - Forensic anthropology OT - Forensic dentistry OT - Molar COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/25 19:30 MHDA- 2026/02/05 00:30 CRDT- 2025/12/25 18:00 PHST- 2025/08/12 00:00 [received] PHST- 2025/12/22 00:00 [accepted] PHST- 2026/02/05 00:30 [medline] PHST- 2025/12/25 19:30 [pubmed] PHST- 2025/12/25 18:00 [entrez] AID - S0379-0738(25)00436-0 [pii] AID - 10.1016/j.forsciint.2025.112792 [doi] PST - ppublish SO - Forensic Sci Int. 2026 Feb;380:112792. doi: 10.1016/j.forsciint.2025.112792. Epub 2025 Dec 23. PMID- 41446995 OWN - NLM STAT- MEDLINE DCOM- 20251225 LR - 20251225 IS - 0300-5283 (Print) IS - 0300-5283 (Linking) VI - 80 IP - Suppl 6 DP - 2025 Dec TI - Depression prevalence and its associated factors among sub-urban residents in Kuala Nerus. PG - 8-15 AB - INTRODUCTION: Depression is a prevalent mental health disorder and a growing public health concern. Understanding its burden, this study aimed to determine the prevalence of depression and identify its associated factors among suburban adult residents of Kuala Nerus, Malaysia. MATERIALS AND METHODS: A community-based cross-sectional study was conducted among 689 adults aged 18 and above who had resided in a suburban area for at least one month and were proficient in Bahasa Malaysia. Data were collected through a house-to-house survey using a pre-tested, validated questionnaire administered via Google Form. Depression was assessed using the Patient Health Questionnaire-9 (PHQ-9), and multiple logistic regression analysis was performed to identify associated factors. RESULTS: The prevalence of depression among respondents was 26.4% (95% CI: 23.1, 29.7). Multiple logistic regression analysis identified several significant factors associated with depression. Older age (adjusted OR: 0.972, 95% CI: 0.948, 0.996; p=0.020), being married (adjusted OR: 0.377, 95% CI: 0.188, 0.754; p=0.006), engaging in physical activity (adjusted OR: 0.669, 95% CI: 0.459, 0.976; p=0.037), and higher total knowledge scores (adjusted OR: 0.883, 95% CI: 0.825, 0.945; p < 0.001) were less likely to have depression. Conversely, being female (adjusted OR: 1.614, 95% CI: 1.076, 2.421; p=0.021) and having a history of depression (adjusted OR: 2.977, 95% CI: 1.122, 7.899; p=0.028) were more likely to have depression. CONCLUSION: The study highlights the substantial burden of depression in suburban communities and underscores the need for targeted mental health interventions. Efforts to improve mental health literacy and promote protective factors, particularly among vulnerable groups such as younger individuals and females, are essential. Further research is warranted to develop effective prevention and treatment strategies. FAU - Aung, M M T AU - Aung MMT AD - Universiti Sultan Zainal Abidin, Department of Community Medicine, Kampus Perubatan, Kuala Terengganu, Malaysia. FAU - Oo, S S AU - Oo SS AD - Universiti Sultan Zainal Abidin, Department of Community Medicine, Kampus Perubatan, Kuala Terengganu, Malaysia. sansanoo@unisza.edu.my. FAU - Mat Azmi, I S M AU - Mat Azmi ISM AD - Universiti Sultan Zainal Abidin, Department of Community Medicine, Kampus Perubatan, Kuala Terengganu, Malaysia. FAU - Megat Mustaqim, M I AU - Megat Mustaqim MI AD - Universiti Sultan Zainal Abidin, Department of Community Medicine, Kampus Perubatan, Kuala Terengganu, Malaysia. FAU - Mazlan, A AU - Mazlan A AD - Universiti Sultan Zainal Abidin, Department of Community Medicine, Kampus Perubatan, Kuala Terengganu, Malaysia. FAU - Naing, N N AU - Naing NN AD - Universiti Sultan Zainal Abidin, Department of Community Medicine, Kampus Perubatan, Kuala Terengganu, Malaysia. FAU - Nik Mahdi, N N R AU - Nik Mahdi NNR AD - Universiti Sultan Zainal Abidin, Department of Community Medicine, Kampus Perubatan, Kuala Terengganu, Malaysia. FAU - Aniza, A A AU - Aniza AA AD - Universiti Sultan Zainal Abidin, Department of Community Medicine, Kampus Perubatan, Kuala Terengganu, Malaysia. FAU - Abas, M I AU - Abas MI AD - Universiti Sultan Zainal Abidin, Department of Community Medicine, Kampus Perubatan, Kuala Terengganu, Malaysia. LA - eng PT - Journal Article PL - Malaysia TA - Med J Malaysia JT - The Medical journal of Malaysia JID - 0361547 SB - IM MH - Humans MH - Malaysia/epidemiology MH - Female MH - Male MH - Adult MH - Middle Aged MH - Cross-Sectional Studies MH - Prevalence MH - *Depression/epidemiology MH - Young Adult MH - Risk Factors MH - Adolescent MH - Aged MH - *Suburban Population/statistics & numerical data MH - Surveys and Questionnaires MH - Logistic Models EDAT- 2025/12/25 07:40 MHDA- 2025/12/25 12:37 CRDT- 2025/12/25 05:43 PHST- 2025/12/25 12:37 [medline] PHST- 2025/12/25 07:40 [pubmed] PHST- 2025/12/25 05:43 [entrez] PST - ppublish SO - Med J Malaysia. 2025 Dec;80(Suppl 6):8-15. PMID- 41446710 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251225 LR - 20251227 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 13 DP - 2025 TI - Development and preliminary clinical feasibility of a Delphi-based aerobic exercise prescription for children with asthma. PG - 1700569 LID - 10.3389/fped.2025.1700569 [doi] LID - 1700569 AB - OBJECTIVE: This study aims to develop a clinically applicable aerobic exercise prescription for children with asthma using a two-round Delphi consensus process and to preliminarily evaluate its feasibility and safety of this prescription in a pre-post pilot study. The secondary goal was to explore preliminary signals of changes in exercise capacity, pulmonary function, and asthma control among asthmatic children after implementing the prescription-with consideration of potential confounding factors such as concurrent medication use and inhaler technique retraining-thereby providing preliminary evidence for non-pharmacological interventions in pediatric asthma management. METHODS: Semi-structured interviews were conducted with 10 parents of asthmatic children, 10 medical professionals, and 10 sports rehabilitation experts to develop an initial aerobic exercise prescription based on the FITT (frequency, intensity, time, type) principle. Subsequently, this initial prescription was iteratively refined through two rounds of Delphi consultation involving 17 experts (specializing in pediatric pulmonology, pediatric nursing, and exercise rehabilitation). A consensus threshold of >/=75% agreement and authority metrics were predefined, and item-level expert feedback was used to modify the prescription. Finally, a 12-week prospective outpatient pilot study was conducted, including 15 asthmatic children aged 6-14 years who implemented the finalized prescription. Feasibility (recruitment rate, exercise adherence), safety (asthma-related adverse events), and clinical outcomes [6 min walk distance (6MWD), spirometry, Childhood Asthma Control Test (C-ACT)] were measured. RESULTS: For the Delphi process, all 17 experts completed both rounds of consultation, with an effective response rate of 94.44% in Round 1 and 100% in Round 2. The expert authority coefficient (Cr) was 0.86, and the coefficient of variation (CV) for item importance scores decreased across rounds (from 0.07-0.16 in Round 1 to 0.07-0.13 in Round 2), indicating high expert consensus. For the pilot study, the recruitment rate reached 100%, and the average weekly exercise adherence was 2.7 +/- 0.3 sessions. The incidence of asthma-related adverse events was 13.3% (mild wheezing and coughing), which did not interrupt training. Post-intervention outcomes showed significant improvements: 6MWD increased from 510.07 +/- 31.96 to 539.27 +/- 44.52 m (P < 0.001); forced expiratory volume in 1 s (FEV1)% predicted increased from 76.87 +/- 5.63 to 87.61 +/- 7.24 (P < 0.001); and C-ACT score increased from 17.60 +/- 1.76 to 22.13 +/- 1.46 (P < 0.001). CONCLUSIONS: The aerobic exercise prescription developed via the Delphi method is feasible and safe for short-term application in children with asthma, with preliminary signals of potential improvements in exercise capacity, pulmonary function, and asthma control. Notably, these observations may be influenced by confounding factors, including concurrent asthma medication adherence and standardized inhaler technique retraining. Due to the small sample size and uncontrolled pre-post design of the pilot study, definitive conclusions on efficacy or independent intervention effects cannot be drawn. CI - (c) 2025 Zhang, Kong, Yang, Li, Yu, Liu, Meng and Zhang. FAU - Zhang, Ying AU - Zhang Y AD - Baoding Hospital of Beijing Children's Hospital, Capital Medical University, Baoding, China. AD - Capital University of Physical Education and Sports, Beijing, China. FAU - Kong, Ze AU - Kong Z AD - Baoding Hospital of Beijing Children's Hospital, Capital Medical University, Baoding, China. FAU - Yang, Kaixuan AU - Yang K AD - Capital University of Physical Education and Sports, Beijing, China. FAU - Li, Zhiqiong AU - Li Z AD - Capital University of Physical Education and Sports, Beijing, China. FAU - Yu, Ziye AU - Yu Z AD - Capital University of Physical Education and Sports, Beijing, China. FAU - Liu, Longyan AU - Liu L AD - Capital University of Physical Education and Sports, Beijing, China. FAU - Meng, Chenxiao AU - Meng C AD - Capital University of Physical Education and Sports, Beijing, China. FAU - Zhang, Jie AU - Zhang J AD - Baoding Hospital of Beijing Children's Hospital, Capital Medical University, Baoding, China. LA - eng PT - Journal Article DEP - 20251209 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC12722912 OTO - NOTNLM OT - Delphi method OT - aerobic exercise prescription OT - asthmatic children OT - evaluation OT - qualitative research COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/25 07:40 MHDA- 2025/12/25 07:41 PMCR- 2025/12/09 CRDT- 2025/12/25 05:12 PHST- 2025/09/07 00:00 [received] PHST- 2025/11/10 00:00 [revised] PHST- 2025/11/11 00:00 [accepted] PHST- 2025/12/25 07:41 [medline] PHST- 2025/12/25 07:40 [pubmed] PHST- 2025/12/25 05:12 [entrez] PHST- 2025/12/09 00:00 [pmc-release] AID - 10.3389/fped.2025.1700569 [doi] PST - epublish SO - Front Pediatr. 2025 Dec 9;13:1700569. doi: 10.3389/fped.2025.1700569. eCollection 2025. PMID- 41446291 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251225 LR - 20251227 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 16 DP - 2025 TI - Associations of the triglyceride-glucose index and its combined indices with non-suicidal self-injury in adolescents with depressive disorders: the mediating role of sleep quality. PG - 1689128 LID - 10.3389/fpsyt.2025.1689128 [doi] LID - 1689128 AB - OBJECTIVE: This study examined the associations between the Triglyceride-Glucose (TyG) index and its combined indices (TyG-BMI, TyG-WC, TyG-WHtR) with non-suicidal self-injury (NSSI) in adolescents with Major Depressive Disorder (MDD). It also explored whether sleep quality mediated these relationships. METHOD: A total of 157 adolescents (12-18 years) with MDD were recruited. Participants were divided into NSSI (n = 78) and non-NSSI (n = 79) groups based on DSM-5 criteria. The TyG index and its derivatives were calculated from fasting blood samples. Analyses included multivariable logistic regression, restricted cubic spline (RCS) analysis, mediation analysis, and receiver operating characteristic (ROC) curves. RESULTS: The NSSI group had higher TyG index values (Median [Q(1), Q(3)]: 8.23 [7.95, 8.45]) than the non-NSSI group (7.73 [7.33, 8.21], P < 0.001). Adjusted regression models confirmed significant associations between TyG indices and NSSI (e.g., TyG: OR = 3.50, 95% CI: 1.82-6.74, P < 0.001), especially in female adolescents. Sleep quality partially mediated the link between TyG and NSSI (proportion mediated = 17.1%, P = 0.026). ROC analysis showed moderate predictive accuracy for TyG-WC (AUC = 0.745, 95% CI: 0.666-0.824). CONCLUSION: The TyG index and its combined indices are positively associated with NSSI in adolescents with MDD. Sleep quality partially mediates this relationship. These indices may serve as low-cost markers for early identification of adolescents at risk for NSSI in clinical practice. CI - Copyright (c) 2025 Liu, Gao, Zhang, Li, Du, Yang and Dong. FAU - Liu, Pu-Le AU - Liu PL AD - Department of Mental Health, The Second Hospital of Lanzhou University, Lanzhou, China. FAU - Gao, Shou AU - Gao S AD - Department of Mental Health, The Second Hospital of Lanzhou University, Lanzhou, China. FAU - Zhang, Yan AU - Zhang Y AD - Department of Mental Health, Mental Health Institute of Central South University, Changsha, China. FAU - Li, Jiao AU - Li J AD - Department of Mental Health, The Second Hospital of Lanzhou University, Lanzhou, China. FAU - Du, Jing AU - Du J AD - Department of Mental Health, The Second Hospital of Lanzhou University, Lanzhou, China. FAU - Yang, Ning AU - Yang N AD - Department of Mental Health, The Second Hospital of Lanzhou University, Lanzhou, China. FAU - Dong, Qiang-Li AU - Dong QL AD - Department of Mental Health, The Second Hospital of Lanzhou University, Lanzhou, China. LA - eng PT - Journal Article DEP - 20251209 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC12722861 OTO - NOTNLM OT - adolescents OT - depressive disorder OT - non-suicidal self-injury OT - sleep quality OT - triglyceride-glucose index COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/25 07:40 MHDA- 2025/12/25 07:41 PMCR- 2025/12/09 CRDT- 2025/12/25 05:04 PHST- 2025/09/05 00:00 [received] PHST- 2025/11/19 00:00 [revised] PHST- 2025/11/24 00:00 [accepted] PHST- 2025/12/25 07:41 [medline] PHST- 2025/12/25 07:40 [pubmed] PHST- 2025/12/25 05:04 [entrez] PHST- 2025/12/09 00:00 [pmc-release] AID - 10.3389/fpsyt.2025.1689128 [doi] PST - epublish SO - Front Psychiatry. 2025 Dec 9;16:1689128. doi: 10.3389/fpsyt.2025.1689128. eCollection 2025. PMID- 41446030 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251225 LR - 20260919 IS - 2673-3129 (Electronic) IS - 2673-3129 (Linking) VI - 7 DP - 2025 TI - An innovative automatic feeding device for preterm infants: promoting the development of sucking ability. PG - 1691199 LID - 10.3389/fmedt.2025.1691199 [doi] LID - 1691199 AB - Preterm infants, particularly those born before 32 weeks of gestation, frequently face challenges in achieving full enteral nutrition due to underdeveloped sucking-swallowing-breathing coordination. Conventional feeding methods, such as the use of indwelling nasogastric tubes, overlook the importance of sucking activity, which is essential for the development of gastrointestinal motility and the secretion of digestive enzymes. To address this issue, we have developed a sucking-rewarded automatic feeding device specifically designed for preterm infants. The device features a specialized pacifier that detects sucking activity and triggers the delivery of a predetermined amount of milk into the stomach via a gastric tube. In addition to promoting sucking-induced satiety, the device continuously monitors sucking waveforms to assess infants' viability and sucking maturity. In a clinical pilot study involving 25 preterm infants, those fed with the device demonstrated a significant increase in intestinal oxygen saturation compared with conventional gavage feeding (p < 0.05). Complementary experiments in 12 newborn beagle puppies showed faster gastric emptying rates (p < 0.01) and elevated gastrointestinal hormone levels (p < 0.05) when using the device. These findings highlight the clinical potential of the proposed device in improving feeding safety, efficiency, and developmental outcomes in preterm infants, and warrant further large-scale clinical trials to validate its long-term efficacy and integration into neonatal care. CI - (c) 2025 Luo, Zhao, Lin, Huang, Liu, Xu and Li. FAU - Luo, Fei AU - Luo F AD - Pediatrics Department, The Second Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China. FAU - Zhao, Xiaoli AU - Zhao X AD - Affiliated Shenzhen Children's Hospital of Shantou University Medical College, Shenzhen, China. FAU - Lin, Yi AU - Lin Y AD - Affiliated Shenzhen Children's Hospital of Shantou University Medical College, Shenzhen, China. FAU - Huang, Huiling AU - Huang H AD - Affiliated Shenzhen Children's Hospital of Shantou University Medical College, Shenzhen, China. FAU - Liu, Zinan AU - Liu Z AD - Affiliated Shenzhen Children's Hospital of Shantou University Medical College, Shenzhen, China. FAU - Xu, Junhong AU - Xu J AD - Shenzhen Kaiyang Industrial Co., Ltd, Shenzhen, Guangdong, China. FAU - Li, Hongping AU - Li H AD - Affiliated Shenzhen Children's Hospital of Shantou University Medical College, Shenzhen, China. LA - eng PT - Journal Article DEP - 20251209 PL - Switzerland TA - Front Med Technol JT - Frontiers in medical technology JID - 101772626 PMC - PMC12722832 OTO - NOTNLM OT - animal experiments OT - automatic feeding device OT - enteral nutrition OT - gastric emptying OT - preterm infants COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/25 07:40 MHDA- 2025/12/25 07:41 PMCR- 2025/12/09 CRDT- 2025/12/25 04:56 PHST- 2025/08/26 00:00 [received] PHST- 2025/11/05 00:00 [revised] PHST- 2025/11/24 00:00 [accepted] PHST- 2025/12/25 07:41 [medline] PHST- 2025/12/25 07:40 [pubmed] PHST- 2025/12/25 04:56 [entrez] PHST- 2025/12/09 00:00 [pmc-release] AID - 10.3389/fmedt.2025.1691199 [doi] PST - epublish SO - Front Med Technol. 2025 Dec 9;7:1691199. doi: 10.3389/fmedt.2025.1691199. eCollection 2025. PMID- 41445802 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251225 LR - 20260919 IS - 2234-943X (Print) IS - 2234-943X (Electronic) IS - 2234-943X (Linking) VI - 15 DP - 2025 TI - Behavioral health interventions for pediatric acute lymphoblastic leukemia: a scoping review. PG - 1697894 LID - 10.3389/fonc.2025.1697894 [doi] LID - 1697894 AB - BACKGROUND: Acute Lymphoblastic Leukemia (ALL) is the most common pediatric cancer, with significant advancements in treatment leading to over 90% five-year event-free survival rates in developed countries. However, disruptions in health behaviors during treatment, such as diet, activity, and sleep, can negatively impact treatment tolerance and increase risks of late effects. This scoping review aimed to assess the breadth of existing behavioral health interventions designed to improve immediate and long-term health outcomes for children and adolescents receiving treatment for ALL. METHOD: The review focused on behavioral interventions for children (ages 2-18 years) undergoing active treatment for ALL. We followed the JBI Manual of Evidence Synthesis and PRISMA-ScR guidelines, including a comprehensive search across PubMed, Elsevier, and Web of Science databases. Articles were screened, assessed, and data extracted by multiple reviewers to identify behavioral health promotion interventions used during ALL treatment. RESULTS: A total of 157 full-text articles were screened, and 86 met inclusion criteria. Most interventions targeted physical activity and exercise (n=36), procedural distress (n=24), nutrition (n=8), and symptom reduction/management (n=6), with others targeting pain, sleep, and health-related quality of life. Date of publication, methodology, and behavioral intervention components varied considerably across studies. CONCLUSIONS: The literature on behavioral health promotion interventions during pediatric ALL treatment is broad but lacks depth, with many studies limited by small sample sizes and stalling at the feasibility stage. There is a need for larger, more rigorous trials to assess the effectiveness of these interventions and improve outcomes for youth with ALL. CI - Copyright (c) 2025 Bates, Gibson, Johnson, Hunt, Dyjak, Gibson, Sharkey and Klages. FAU - Bates, Carolyn R AU - Bates CR AD - Department of Pediatrics, University of Kansas Medical Center, University of Kansas Cancer Center, Kansas City, KS, United States. FAU - Gibson, Sydney M AU - Gibson SM AD - Kansas City University College of Osteopathic Medicine, Kansas City, MO, United States. FAU - Johnson, Peter R AU - Johnson PR AD - A.R. Dykes Library, University of Kansas Medical Center, Kansas City, KS, United States. FAU - Hunt, Sarah L AU - Hunt SL AD - Department of Psychology, The Catholic University of America, Washington, DC, United States. FAU - Dyjak, Patrick M AU - Dyjak PM AD - Kansas City University College of Osteopathic Medicine, Kansas City, MO, United States. FAU - Gibson, Courtney A AU - Gibson CA AD - Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinatti, OH, United States. FAU - Sharkey, Christina M AU - Sharkey CM AD - Department of Psychology, The Catholic University of America, Washington, DC, United States. FAU - Klages, Kimberly L AU - Klages KL AD - Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinatti, OH, United States. LA - eng GR - K08 CA279877/CA/NCI NIH HHS/United States PT - Journal Article PT - Review DEP - 20251209 PL - Switzerland TA - Front Oncol JT - Frontiers in oncology JID - 101568867 PMC - PMC12722908 OTO - NOTNLM OT - acute lymphoblastic leukemia (ALL) OT - behavioral health OT - behavioral intervention OT - health behavior OT - pediatric COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/25 07:40 MHDA- 2025/12/25 07:41 PMCR- 2025/12/09 CRDT- 2025/12/25 04:52 PHST- 2025/09/02 00:00 [received] PHST- 2025/10/31 00:00 [accepted] PHST- 2025/12/25 07:41 [medline] PHST- 2025/12/25 07:40 [pubmed] PHST- 2025/12/25 04:52 [entrez] PHST- 2025/12/09 00:00 [pmc-release] AID - 10.3389/fonc.2025.1697894 [doi] PST - epublish SO - Front Oncol. 2025 Dec 9;15:1697894. doi: 10.3389/fonc.2025.1697894. eCollection 2025. PMID- 41445558 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251225 LR - 20251227 IS - 2473-4039 (Electronic) IS - 2473-4039 (Linking) VI - 9 IP - Suppl 5 DP - 2025 Dec TI - Harmonized Tubular Maximum Phosphate reabsorption per Glomerular Filtration Rate reporting in adults and children in Australia and New Zealand. PG - v94-v100 LID - 10.1093/jbmrpl/ziae140 [doi] AB - Tubular maximum phosphate reabsorption per glomerular filtration rate (TmP/GFR) is a key diagnostic test for renal phosphate wasting. However, there is a lack of international consensus regarding the reporting of age-related reference intervals. The TmP/GFR Harmonization Working Group, formed by The Australasian Association for Clinical Biochemistry (AACB) and Laboratory Medicine and The Australian and New Zealand Bone and Mineral Society (ANZBMS), aimed to evaluate analytical differences amongst commercial creatinine and phosphate assays, harmonize age-specific cut-offs and compare the ANZBMS TmP/GFR online calculator with existing products. A total of 11 360 results from The Royal College of Pathologists of Australasia Quality Assurance Programs were analyzed to assess creatinine and phosphate assay performance amongst 5 in vitro diagnostic (IVD) companies. Ortho-Clinical Diagnostics analyzers had a positive bias of up to 32% for serum phosphate and up to 29% for TmP/GFR. The other IVD companies produced comparable results and are suitable for harmonized reference intervals. To date, the AACB-ANZBMS TmP/GFR online calculator is the only validated Isotope Dilution Mass Spectrometry-creatinine aligned tool which caters for both pediatric and adult individuals, providing automatic interpretive comments to aid clinicians managing patients with hypophosphatemia. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of the American Society for Bone and Mineral Research. FAU - Chiang, Cherie AU - Chiang C AD - Department of Medicine, University of Melbourne, Parkville, VIC 3050, Australia. AD - Department of Endocrinology, Austin Health, Heidelberg, VIC 3084, Australia. FAU - Choy, Kay Weng AU - Choy KW AD - Department of Pathology, Northern Health, Epping, VIC 3076, Australia. FAU - Coates, Penelope AU - Coates P AD - Department of Chemical Pathology, SA Pathology, Adelaide, SA 5000, Australia. FAU - Carrivick, Simon AU - Carrivick S AD - Department of Biochemistry, Pathwest QEII Medical Centre, Nedlands, SA 6009 Australia. FAU - Farrell, Christopher J AU - Farrell CJ AD - New South Wales Health Pathology, Liverpool Hospital, Liverpool, NSW 2170, Australia. FAU - Clifton-Bligh, Roderick J AU - Clifton-Bligh RJ AD - Department of Endocrinology, Royal North Shore Hospital, St Leonards, NSW 2065, Australia. FAU - Lim, Ee Mun AU - Lim EM AD - Department of Biochemistry, Pathwest QEII Medical Centre, Nedlands, SA 6009 Australia. LA - eng PT - Journal Article DEP - 20251206 PL - England TA - JBMR Plus JT - JBMR plus JID - 101707013 PMC - PMC12723803 OTO - NOTNLM OT - X-linked hypophosphatemia (XLH) OT - hypophosphatemia OT - online calculator OT - osteomalacia OT - tubular maximum phosphate reabsorption per glomerular filtration rate COIS- C.C. received honoraria from Amgen and Specialised Therapeutics. P.C. and R.C.-B. received honoraria from Kyowa Kirin. EDAT- 2025/12/25 07:40 MHDA- 2025/12/25 07:41 PMCR- 2025/12/06 CRDT- 2025/12/25 04:48 PHST- 2024/08/28 00:00 [received] PHST- 2024/10/21 00:00 [revised] PHST- 2024/11/06 00:00 [accepted] PHST- 2025/12/25 07:41 [medline] PHST- 2025/12/25 07:40 [pubmed] PHST- 2025/12/25 04:48 [entrez] PHST- 2025/12/06 00:00 [pmc-release] AID - ziae140 [pii] AID - 10.1093/jbmrpl/ziae140 [doi] PST - epublish SO - JBMR Plus. 2025 Dec 6;9(Suppl 5):v94-v100. doi: 10.1093/jbmrpl/ziae140. eCollection 2025 Dec. PMID- 41445451 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20260910 IS - 1741-3850 (Electronic) IS - 1741-3842 (Linking) VI - 48 IP - 1 DP - 2026 Mar 6 TI - Predictive value of the EHIS-PAQ for all-cause mortality. PG - 263-271 LID - 10.1093/pubmed/fdaf158 [doi] AB - BACKGROUND: The European Health Interview Survey-Physical Activity Questionnaire (EHIS-PAQ) assesses physical activity (PA) as part of the European Health Interview Survey. The aim of this study was to evaluate its predictive value for all-cause mortality. METHODS: A prospective study based on data from the 2014 EHIS in Spain linked to the mortality registry until December 2022. The sample included 21 890 participants >/=15 years of age. The EHIS-PAQ measures occupational PA, transport/commuting PA, aerobic PA >/= 150 minutes/week, muscle strengthening, and total PA (active in occupational and/or aerobic). We designed Poisson regression models to calculate relative risks (RRs) and standardized mortality rate differences while adjusting for relevant covariates. RESULTS: Total PA was associated with a reduction in mortality [RR (95% CI) = 0.62 (0.54, 0.71)], estimating -5.39 (-6.72, -4.07) deaths/1000 person-years. Independent of other PA domains, most active individuals in occupational or transport/commuting PA had substantially reduced mortality compared to those least active [RR = 0.67 (0.55, 0.82) and 0.52 (0.44, 0.62)]. Engaging in >/=150 minutes/week of aerobic PA was protective [RR = 0.68 (0.58, 0.79)]. Muscle strengthening PA showed no effect. CONCLUSIONS: The EHIS-PAQ adequately assesses PA in its different dimensions and captures their protective effect. All the indicators, except for muscle strengthening, showed independent predictive value for mortality. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of the Faculty of Public Health. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Martinez-Portillo, Alejandro AU - Martinez-Portillo A AUID- ORCID: 0000-0002-7068-5821 AD - Service of Epidemiology, General Directorate of Public Health and Addictions, Ronda de Levante, 11, CP 30008, Murcia, Region de Murcia, Spain. AD - Instituto Murciano de Investigacion Biosanitaria (IMIB), C/ Luis Fontes Pagan 9, CP 30003, Murcia, Spain. FAU - de la Camara, Miguel Angel AU - de la Camara MA AUID- ORCID: 0000-0003-0015-7350 AD - Department of Educational Sciences, University of Alcala (UAH), C/ San Cirilo, s/n, CP 28804, Alcala de Henares, Spain. FAU - Granero-Melcon, Beatriz AU - Granero-Melcon B AUID- ORCID: 0000-0001-8525-5405 AD - National School of Health, Instituto de Salud Carlos III, C/Sinesio Delgado, 10, Fuencarral-El Pardo, 28029, Madrid, Spain. FAU - Ortiz, Cristina AU - Ortiz C AUID- ORCID: 0000-0002-9049-5785 AD - National Centre for Epidemiology, Instituto de Salud Carlos III, C/ Melchor Fernandez Almagro, 5, Fuencarral-El Pardo, 28029 Madrid, Spain. FAU - Neira-Leon, Montserrat AU - Neira-Leon M AUID- ORCID: 0009-0005-4420-8609 AD - Health Information Sub-directorate, Ministry of Health, P. degrees del Prado, 18, Centro, 28014 Madrid, Spain. FAU - Galan, Inaki AU - Galan I AUID- ORCID: 0000-0003-0624-9993 AD - National Centre for Epidemiology, Instituto de Salud Carlos III, C/ Melchor Fernandez Almagro, 5, Fuencarral-El Pardo, 28029 Madrid, Spain. AD - Department of Preventive Medicine and Public Health. Autonomous University of Madrid, C/ del Arzobispo Morcillo 4, CP 28029, Madrid, Spain. LA - eng GR - Institute of Health Carlos III/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - England TA - J Public Health (Oxf) JT - Journal of public health (Oxford, England) JID - 101188638 SB - IM MH - Humans MH - Male MH - Female MH - *Exercise MH - Prospective Studies MH - Middle Aged MH - Adult MH - Spain/epidemiology MH - *Mortality/trends MH - Aged MH - Health Surveys MH - Surveys and Questionnaires MH - Adolescent MH - Young Adult MH - Predictive Value of Tests MH - Cause of Death OTO - NOTNLM OT - all-cause mortality OT - physical activity OT - prospective study OT - questionnaire EDAT- 2025/12/25 07:40 MHDA- 2026/03/07 16:11 CRDT- 2025/12/25 03:43 PHST- 2025/07/31 00:00 [received] PHST- 2025/11/06 00:00 [revised] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/03/07 16:11 [medline] PHST- 2025/12/25 07:40 [pubmed] PHST- 2025/12/25 03:43 [entrez] AID - 8404610 [pii] AID - 10.1093/pubmed/fdaf158 [doi] PST - ppublish SO - J Public Health (Oxf). 2026 Mar 6;48(1):263-271. doi: 10.1093/pubmed/fdaf158. PMID- 41444560 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Dec 24 TI - Social determinants of health and menopausal symptoms: path analysis using the WHO framework. PG - 4304 LID - 10.1186/s12889-025-25612-w [doi] LID - 4304 AB - INTRODUCTION: Menopausal symptoms frequently occur in middle-aged women and severely reduce their quality of life worldwide. Considering the potential influences of social determinants of health on menopausal symptoms, this study investigated the relationship between social determinants of health, as outlined by the World Health Organization framework, and menopausal symptoms among Iranian women. METHOD: This cross-sectional study was conducted on 465 women aged 45 to 55 attending health centers in Kashan, Iran, between March and September 2024. Participants were selected via convenience sampling from a pool of women attending routine check-ups. Data were collected using six validated questionnaires: (1) a demographic and obstetric information survey (age, parity, etc.) (2), a socioeconomic status assessment (income, education) (3), the Multidimensional Scale of Perceived Social Support (MSPSS) (4), the WHO Intimate Partner Violence Questionnaire (WHO-IPV) (5), Sharkey Physical Activity Questionnaire, and (6) the Menopause Rating Scale (MRS) for symptom severity. Data were analyzed using SPSS 27 for descriptive statistics and LISREL 8.8 for path analysis, which modeled direct and indirect effects. RESULTS: Path analysis identified several social determinants directly influencing menopausal symptom severity. Domestic violence (B = 0.073, p < 0.05) and parity (B = 0.84, p < 0.01) were positively associated with symptom severity, indicating that higher exposure to violence or more childbirths worsened symptoms. In contrast, perceived social support (B=-0.15, p < 0.05) and physical activity (B=-0.25, p < 0.01) showed negative associations, suggesting protective effects. Indirect effects emerged from socioeconomic status (B=-0.29, p < 0.05), age (B = 0.11, p < 0.05), and spouse's education (B=-0.25, p < 0.05), mediated through variables like support and activity levels. BMI uniquely influenced symptoms via direct and indirect paths (B = 0.38, p < 0.01), with higher BMI linked to greater severity. The model demonstrated excellent fit: RMSEA = 0.027 (< 0.06), GFI = 0.99 (> 0.90), CFI = 0.97 (> 0.90), and chi(2)/df = 2.24 (< 3), confirming its robustness. CONCLUSION: Social determinants of health significantly influence menopausal symptom severity. Domestic violence and higher parity worsened symptoms, while social support and physical activity had protective effects. Socioeconomic status, spouse's education, and BMI also contributed through direct and indirect pathways. These findings could help healthcare providers identify menopausal and perimenopausal women at risk for severe symptoms and provide women with strategies to reduce symptoms, such as weight loss and physical activity. FAU - Vakili, Fatemeh AU - Vakili F AD - School of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. AD - Researcher at Sexual and Reproductive Health Research Center, Mazandaran University of Medical Sciences, Sari, Iran. FAU - Nasiri, Malihe AU - Nasiri M AD - Department of Basic Sciences, Faculty of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran. FAU - Jahanfar, Shayesteh AU - Jahanfar S AD - Department of Public Health and Community Medicine, Tufts University School of Medicine, Boston, MA, USA. FAU - Shishehgar, Sara AU - Shishehgar S AD - School of Nursing and Midwifery, Western Sydney University, Sydney, NSW, Australia. FAU - Mahmoodi, Zohreh AU - Mahmoodi Z AD - Social Determinants of Health Research Center, Alborz University of Medical Sciences, Karaj, Iran. FAU - Hamzehgardeshi, Zeinab AU - Hamzehgardeshi Z AD - Sexual and Reproductive Health Research Center, Mazandaran University of Medical Sciences, Sari, Iran. hamzehgardeshi@yahoo.com. FAU - Alamolhoda, Seideh Hanieh AU - Alamolhoda SH AD - Department of Midwifery and Reproductive Health, Midwifery and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. alamolhoda.h@yahoo.com. LA - eng PT - Journal Article DEP - 20251224 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Middle Aged MH - Cross-Sectional Studies MH - Iran/epidemiology MH - *Menopause/physiology MH - *Social Determinants of Health/statistics & numerical data MH - World Health Organization MH - Surveys and Questionnaires MH - Social Support MH - Socioeconomic Disparities in Health PMC - PMC12729258 OTO - NOTNLM OT - Menopausal symptoms OT - Menopause OT - Path analysis OT - Social determinants of health OT - WHO framework COIS- Declarations. Ethics approval and consent to participate: All methods were carried out following relevant guidelines and regulations or Declaration of Helsinki. Informed consent was obtained from all subjects and/or their legal guardian(s). This research was approved by the Ethics Committee of the Faculty of Nursing and Midwifery, Shahid Beheshti University of Medical Sciences with ethics code IR. SBMU.PHARMACY.REC.1403.281. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/25 00:29 MHDA- 2026/06/27 06:45 PMCR- 2025/12/24 CRDT- 2025/12/24 23:38 PHST- 2025/03/06 00:00 [received] PHST- 2025/11/07 00:00 [accepted] PHST- 2026/06/27 06:45 [medline] PHST- 2025/12/25 00:29 [pubmed] PHST- 2025/12/24 23:38 [entrez] PHST- 2025/12/24 00:00 [pmc-release] AID - 10.1186/s12889-025-25612-w [pii] AID - 25612 [pii] AID - 10.1186/s12889-025-25612-w [doi] PST - epublish SO - BMC Public Health. 2025 Dec 24;25(1):4304. doi: 10.1186/s12889-025-25612-w. PMID- 41442705 OWN - NLM STAT- MEDLINE DCOM- 20251224 LR - 20260908 IS - 2291-5222 (Electronic) IS - 2291-5222 (Linking) VI - 13 DP - 2025 Dec 24 TI - Smartphone App-Based Exercise for Pregnant Women in Indonesia: Quasi-Experimental Study on Physical Activity, Fear of Childbirth, and Quality of Life. PG - e73105 LID - 10.2196/73105 [doi] LID - e73105 AB - BACKGROUND: Pregnancy, a vital phase in a woman's life, entails immense physical, psychological, and emotional alterations that might affect maternal health. Physical activity during pregnancy improves health outcomes; however, adherence to the recommendation is low. Moreover, fear of childbirth (FoC) has a negative impact on maternal mental health and quality of life (QoL). Mobile health (mHealth) interventions, especially those delivered through smartphone-based exercise management apps, provide a scalable solution to improve maternal health outcomes. OBJECTIVE: This study aims to assess the impact of an exercise management intervention based on a smartphone app on physical activity, FoC, and QoL in pregnant women in Indonesia. METHODS: We used a quasi-experimental design with repeated measures, conducted at public health centers in West Java, Indonesia. A total of 240 pregnant women were recruited through convenience sampling and allocated to either an intervention group (n=120), which received a smartphone app-based exercise and behavioral program, or a control group (n=120), which received standard prenatal care. Data were collected at 3 time points: baseline measurement (T0), postintervention measurement (T1), and 1-month follow-up measurement (T2). The intervention targeted improvements in physical activity, reduction of FoC, and enhancement of QoL. Validated instruments were used to assess outcomes, including the Pregnancy Physical Activity Questionnaire (PPAQ), the Wijma Delivery Expectation Questionnaire Version A (WDEQ-A), and the Quality-of-Life Gravidarum (QOL-GRAV) scale. Statistical analyses were performed using repeated measures ANOVA with Bonferroni post hoc tests, and effect sizes were calculated using Cohen d. RESULTS: The intervention group had significant increases in physical activity levels from T0 to T1 (Cohen d=0.65; P<.001) and from T0 to T2 (Cohen d=0.72, P<.001), whereas there were no significant changes in the control group. FoC scores were significantly lower at T1 (Cohen d=0.52; P<.001) and T2 (Cohen d=0.56; P<.001) compared to T0 in the intervention group, but no changes were observed in the control group. QoL scores increased significantly in the intervention group from T0 to T1 (Cohen d=0.60; P<.001) and from T0 to T2 (Cohen d=0.68; P<.001), while there were no significant changes noted in the control group. CONCLUSIONS: The exercise management intervention using the smartphone app was effective in increasing physical activity, reducing FoC, and improving QoL among pregnant women in Indonesia. The intervention represents a scalable and accessible mechanism through which maternal health can be improved in limited-resource contexts. Large-scale, long-term studies are needed to evaluate the sustainability of the benefits observed and the incorporation of mHealth solutions in standard prenatal management. CI - (c)Dewi Marfuah, Tukimin Bin Sansuwito, Rathimalar Ayakannu. Originally published in JMIR mHealth and uHealth (https://mhealth.jmir.org), 24.12.2025. FAU - Marfuah, Dewi AU - Marfuah D AUID- ORCID: 0000-0002-9114-4661 AD - Sekolah Tinggi Ilmu Keperawatan Persatuan Perawat Nasional Indonesia (PPNI) Jawa Barat, Bandung, West Java, Indonesia. FAU - Sansuwito, Tukimin Bin AU - Sansuwito TB AUID- ORCID: 0000-0001-7323-4308 AD - Faculty of Nursing and Allied Health, Lincoln University College, Petaling Jaya, Selangor, Malaysia. FAU - Ayakannu, Rathimalar AU - Ayakannu R AUID- ORCID: 0000-0002-9146-8287 AD - Faculty of Nursing and Allied Health, Lincoln University College, Petaling Jaya, Selangor, Malaysia. LA - eng PT - Journal Article DEP - 20251224 PL - Canada TA - JMIR Mhealth Uhealth JT - JMIR mHealth and uHealth JID - 101624439 SB - IM MH - Humans MH - Female MH - Indonesia MH - Pregnancy MH - *Quality of Life/psychology MH - *Mobile Applications/standards/statistics & numerical data MH - Adult MH - *Exercise/psychology MH - *Pregnant People/psychology MH - *Fear/psychology MH - Surveys and Questionnaires MH - *Parturition/psychology MH - Psychometrics/methods/instrumentation MH - Telemedicine MH - Smartphone PMC - PMC12780703 OTO - NOTNLM OT - fear of childbirth OT - mobile health OT - physical activity OT - pregnancy OT - quality of life OT - smartphone app COIS- Conflicts of Interest: None declared. EDAT- 2025/12/24 19:33 MHDA- 2025/12/24 19:34 PMCR- 2025/12/24 CRDT- 2025/12/24 16:53 PHST- 2025/02/25 00:00 [received] PHST- 2025/07/30 00:00 [accepted] PHST- 2025/06/13 00:00 [revised] PHST- 2025/12/24 19:34 [medline] PHST- 2025/12/24 19:33 [pubmed] PHST- 2025/12/24 16:53 [entrez] PHST- 2025/12/24 00:00 [pmc-release] AID - v13i1e73105 [pii] AID - 10.2196/73105 [doi] PST - epublish SO - JMIR Mhealth Uhealth. 2025 Dec 24;13:e73105. doi: 10.2196/73105. PMID- 41441866 OWN - NLM STAT- MEDLINE DCOM- 20260715 LR - 20260715 IS - 2168-6602 (Electronic) IS - 0890-1171 (Linking) VI - 40 IP - 7 DP - 2026 Sep TI - Physical Activity and Sleep as Predictors of Well-Being in Young Adults. PG - 811-819 LID - 10.1177/08901171251409404 [doi] AB - PurposeTo examine physical activity and sleep as predictors of well-being in young adults and explore differences by sex, age, and student status.Design & SettingA cross-sectional, online survey containing validated questionnaires was utilized to measure self-reported physical activity, sleep, and well-being.SampleParticipants were recruited through local and national recruitment efforts and social media. Of 329 survey respondents, 230 adults (69.9%) aged 18-25 years without current injury or physical activity limitations completed the survey between April 2020 and September 2020.MeasuresQuestionnaires utilized included the Godin Leisure Time Exercise Questionnaire for physical activity, the Pittsburgh Sleep Quality Index for sleep, and the Physical Summary Component and Mental Summary Component of the Modified Disablement in the Physically Active Scale for physical and mental well-being.AnalysisLinear regression models, Welch 2 Sample t-tests, Analysis of Variance, Tukey's Honest Significant Difference tests, chi-square tests of independence, F-tests, and stepwise AIC techniques were utilized in data analyses.ResultsSleep quality was the strongest predictor of mental and physical well-being (Estimate = 0.500, P < .001). While no differences in sleep quality or well-being were identified by sex, age, or student status, physical activity was higher among males and younger participants.ConclusionYoung adulthood is a crucial time to establish healthy physical activity and sleep patterns to promote well-being. Collection of data during the COVID pandemic may limit generalizability of results. FAU - Vanderford, Cheryl AU - Vanderford C AUID- ORCID: 0009-0002-7091-6041 AD - Physician Assistant Studies, University of Kentucky, Lexington, KY, USA. RINGGOLD: 4530 FAU - Dlugonski, Deirdre AU - Dlugonski D AD - Department of Athletic Training and Clinical Nutrition, University of Kentucky, Lexington, KY, USA. FAU - Potter, Daniel AU - Potter D AD - Physician Assistant Studies, University of Kentucky, Lexington, KY, USA. RINGGOLD: 4530 FAU - Hoch, Johanna M AU - Hoch JM AD - Department of Athletic Training and Clinical Nutrition, University of Kentucky, Lexington, KY, USA. LA - eng PT - Journal Article DEP - 20251224 PL - United States TA - Am J Health Promot JT - American journal of health promotion : AJHP JID - 8701680 SB - IM MH - Humans MH - *Exercise/psychology MH - Male MH - Young Adult MH - Female MH - Adolescent MH - Cross-Sectional Studies MH - Psychological Well-Being MH - *Sleep MH - Adult MH - *Sleep Quality MH - Surveys and Questionnaires MH - COVID-19/epidemiology MH - *Mental Health MH - Sex Factors MH - Age Factors MH - Self Report MH - Sleep Duration OTO - NOTNLM OT - age OT - mental health OT - physical activity OT - predictors of well-being OT - self-reported physical activity OT - sex OT - sleep OT - sleep quality OT - student status OT - well-being OT - young adult COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/12/24 12:55 MHDA- 2026/07/15 18:41 CRDT- 2025/12/24 10:44 PHST- 2026/07/15 18:41 [medline] PHST- 2025/12/24 12:55 [pubmed] PHST- 2025/12/24 10:44 [entrez] AID - 10.1177/08901171251409404 [doi] PST - ppublish SO - Am J Health Promot. 2026 Sep;40(7):811-819. doi: 10.1177/08901171251409404. Epub 2025 Dec 24. PMID- 41441188 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251224 LR - 20251226 IS - 2409-9279 (Electronic) IS - 2409-9279 (Linking) VI - 8 IP - 6 DP - 2025 Dec 1 TI - Simultaneous Analysis of L-Carnitine and Acetyl-L-Carnitine in Food Samples by Hydrophilic Interaction Nano-Liquid Chromatography. LID - 10.3390/mps8060145 [doi] LID - 145 AB - L-Carnitine (L-CAR) and acetyl-L-carnitine (Acetyl L-CAR) are the essential cofactor compounds in lipid metabolism and are used in the treatment of various diseases. The European Food Safety Authority (EFSA) has reported that Acetyl-L-CAR contributes to normal cognitive function and has a beneficial physiological effect. Therefore, the sensitive separation and determination of L-CAR and Acetyl-L-CAR in foodstuffs can provide critical information. A notable trend in modern food analysis is the increasing use of miniaturized analytical columns with a narrow inner diameter (ID). In this study, a new, green analytical method for food analysis was developed to analyze L-CAR and Acetyl-L-CAR in food samples by nano-LC/UV with a hydrophilic monolithic 100 microm ID capillary. This is the first time that the preparation and application of a hydrophilic monolithic nano-column for the analysis of L-CAR and Acetyl-L-CAR in food samples by nano LC/UV has been reported. The hydrophilic monolith was prepared using in situ co-polymerization of glyceryl methacrylate (GMM) and ethylene dimethacrylate (EDMA). Following preparation and characterization, the hydrophilic monolith was used to analyze L-CAR and Acetyl-L-CAR in food samples, including three infant powdered milk samples and five supplements using nano LC/UV. The developed method was validated in terms of precision, sensitivity, linearity, recovery, and repeatability. The LOD and LOQ values were found to be in the range of 0.04-0.09 microg/kg, respectively. In short, the proposed method proved to be suitable for the routine analysis of L-CAR and Acetyl-L-CAR in food samples. FAU - Aydogan, Cemil AU - Aydogan C AUID- ORCID: 0000-0002-7692-0423 AD - Food Analysis and Research Laboratory, Bingol University, Bingol 12000, Turkiye. AD - Department of Food Engineering, Bingol University, Bingol 12000, Turkiye. AD - Department of Chemistry, Bingol University, Bingol 12000, Turkiye. FAU - Ercan, Muhammed AU - Ercan M AUID- ORCID: 0000-0002-8334-1454 AD - Graduate School of Natural and Applied Sciences, Bingol University, Bingol 12000, Turkiye. FAU - El Rassi, Ziad AU - El Rassi Z AUID- ORCID: 0000-0001-8018-6244 AD - Department of Chemistry, Oklahoma State University, Stillwater, OK 74078-3071, USA. LA - eng PT - Journal Article DEP - 20251201 PL - Switzerland TA - Methods Protoc JT - Methods and protocols JID - 101720073 PMC - PMC12735929 OTO - NOTNLM OT - HPLC OT - carnitine OT - dietary food supplements OT - milk OT - monolith OT - nano-LC COIS- The authors declare no conflict of interest. EDAT- 2025/12/24 12:55 MHDA- 2025/12/24 12:56 PMCR- 2025/12/01 CRDT- 2025/12/24 09:52 PHST- 2025/10/04 00:00 [received] PHST- 2025/11/27 00:00 [revised] PHST- 2025/11/28 00:00 [accepted] PHST- 2025/12/24 12:56 [medline] PHST- 2025/12/24 12:55 [pubmed] PHST- 2025/12/24 09:52 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - mps8060145 [pii] AID - mps-08-00145 [pii] AID - 10.3390/mps8060145 [doi] PST - epublish SO - Methods Protoc. 2025 Dec 1;8(6):145. doi: 10.3390/mps8060145. PMID- 41441034 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251224 LR - 20251226 IS - 2218-1989 (Print) IS - 2218-1989 (Electronic) IS - 2218-1989 (Linking) VI - 15 IP - 12 DP - 2025 Dec 12 TI - Diagnosis and Management of Pediatric Non-Alcoholic Fatty Liver Disease: An Overview. LID - 10.3390/metabo15120792 [doi] LID - 792 AB - Non-alcoholic fatty liver disease (NAFLD) is the most common pediatric chronic liver disease worldwide, with an increasing prevalence, mainly due to the increase in childhood obesity and sedentary lifestyle. The pathogenesis of NAFLD is multifactorial, but the mechanisms by which the factors involved, namely the genetic, intrauterine and environmental factors responsible for its onset and progression to NASH, are not fully known. Children with NAFLD are usually asymptomatic or show nonspecific symptoms, and NAFLD is generally diagnosed incidentally by screening tests in overweight or obese children. NAFLD is associated with severe metabolic deficiencies that may progress to cirrhosis and hepatocellular carcinoma, with the consequent need for liver transplantation. Current treatment of NAFLD in children consists of lifestyle changes to decrease caloric intake and increase physical activity, with no currently approved pharmacological medication for the pediatric population. Although pediatric studies that focus on alternative treatments targeting key pathogenic factors are promising, no pharmacological agent is currently approved for children, validated non-invasive fibrosis biomarkers remain limited, and long-term outcome data are scarce. Further validation through large prospective pediatric cohorts and phase III trials is urgently needed. FAU - Dop, Dalia AU - Dop D AUID- ORCID: 0009-0006-6065-2782 AD - Department of Pediatrics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. FAU - Padureanu, Vlad AU - Padureanu V AUID- ORCID: 0000-0001-7398-5689 AD - Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. FAU - Padureanu, Rodica AU - Padureanu R AD - Department of Internal Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. FAU - Niculescu, Carmen Elena AU - Niculescu CE AD - Department of Pediatrics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. FAU - Niculescu, Stefan Adrian AU - Niculescu SA AD - Department of Orthopedics, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. FAU - Marcu, Iulia Rahela AU - Marcu IR AD - Department of Physical and Rehabilitation Medicine, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania. LA - eng PT - Journal Article PT - Review DEP - 20251212 PL - Switzerland TA - Metabolites JT - Metabolites JID - 101578790 PMC - PMC12735121 OTO - NOTNLM OT - NAFLD OT - children OT - gut microbiota OT - liver fibrosis OT - metabolic dysfunction COIS- The authors declare no conflicts of interest. EDAT- 2025/12/24 12:54 MHDA- 2025/12/24 12:55 PMCR- 2025/12/12 CRDT- 2025/12/24 09:47 PHST- 2025/10/02 00:00 [received] PHST- 2025/12/03 00:00 [revised] PHST- 2025/12/11 00:00 [accepted] PHST- 2025/12/24 12:55 [medline] PHST- 2025/12/24 12:54 [pubmed] PHST- 2025/12/24 09:47 [entrez] PHST- 2025/12/12 00:00 [pmc-release] AID - metabo15120792 [pii] AID - metabolites-15-00792 [pii] AID - 10.3390/metabo15120792 [doi] PST - epublish SO - Metabolites. 2025 Dec 12;15(12):792. doi: 10.3390/metabo15120792. PMID- 41439490 OWN - NLM STAT- Publisher LR - 20251224 IS - 0975-5764 (Electronic) IS - 0975-5764 (Linking) DP - 2025 Dec 24 TI - Shaping Young Appetites: The Role of Sociodemographic, Lifestyle, and Physical Activity Factors in Food Preferences and Dietary Habits among School Children. LID - 10.4103/aam.aam_614_25 [doi] AB - CONTEXT: Food preferences and dietary habits among school children are influenced by sociodemographic, anthropometric, lifestyle, and physical activity factors. Understanding these associations is crucial for designing effective interventions to promote healthy eating habits. AIMS: This study aimed to investigate the factors such as sociodemographics, anthropometry, physical activity, and lifestyle influencing food preferences and dietary habits among school children. SETTINGS AND DESIGN: A cross-sectional study was conducted among 422 students from four schools in Mangaluru between January and December 2021. MATERIALS AND METHODS: Data on sociodemographics, anthropometry, lifestyle, physical activity, and diet were collected using a validated questionnaire. Continuous variables were expressed as medians (interquartile range) and categorical variables as frequencies. Group differences were tested with Mann-Whitney U-test and Chi-square tests. Logistic regression generated crude and adjusted odds ratios with 95% confidence intervals (CIs). Subgroup analyses explored snacking patterns. P <0.05 was considered statistically significant. RESULTS: Among participants, 44.8% had normal status, 29.9% underweight, and 25.4% overweight. Vegetable preference was lower in middle-income groups (CI = 0.282-0.764, P = 0.003) but higher for milk products in high-income (CI = 1.452-11.19, P = 0.007) and very-healthy lifestyles (CI = 0.634-5.34, P < 0.001). Moderate physical activity increased preference for vegetables (CI = 1.067-2.747, P = 0.026) and snacks (CI = 1.128-3.82, P = 0.019) with higher fruit (OR = 1.141-3.35, P = 0.015), vegetable (CI = 1.207-3.30, P = 0.007), nonvegetarian foods (CI = 1.462-3.91, P < 0.001), and milk products consumption (CI = 1.350-3.44, P = 0.001). Moderately healthy lifestyles reduced fast food preference (CI = 0.368-0.988, P = 0.045) and raised vegetable intake further in very-healthy groups (CI = 1.138-4.16, P = 0.019). Evening-snacking predominated (chi(2) =260.3, P < 0.001). Boys were more active (P = 0.014). CONCLUSIONS: Food preferences reflected actual consumption and were shaped by higher income, physical activity, and healthier lifestyles. Gender-sensitive, context-specific, targeted school, and community-based nutrition education with parental involvement can reduce future chronic-disease risk among school children. CI - Copyright (c) 2025 Annals of African Medicine. FAU - Chatterjee, Poulomi AU - Chatterjee P AD - Department of Community Medicine, Yenepoya Medical College, Yenepoya (Deemed to be University), Mangaluru, Karnataka, India. FAU - Nirgude, Abhay Subhashrao AU - Nirgude AS LA - fre LA - eng PT - Journal Article DEP - 20251224 PL - India TA - Ann Afr Med JT - Annals of African medicine JID - 101231417 SB - IM OTO - NOTNLM OT - Child OT - Enfant OT - choix alimentaires OT - comportement alimentaire OT - eating behavior OT - exercice OT - exercise OT - food selections OT - health-education OT - lifestyle OT - mode de vie OT - schools OT - ecoles OT - education pour la sante EDAT- 2025/12/24 12:55 MHDA- 2025/12/24 12:55 CRDT- 2025/12/24 06:52 PHST- 2025/10/06 00:00 [received] PHST- 2025/11/18 00:00 [accepted] PHST- 2025/12/24 12:55 [medline] PHST- 2025/12/24 12:55 [pubmed] PHST- 2025/12/24 06:52 [entrez] AID - 01244624-990000000-00464 [pii] AID - 10.4103/aam.aam_614_25 [doi] PST - aheadofprint SO - Ann Afr Med. 2025 Dec 24. doi: 10.4103/aam.aam_614_25. PMID- 41437821 OWN - NLM STAT- MEDLINE DCOM- 20260504 LR - 20260830 IS - 1592-8721 (Electronic) IS - 0390-6078 (Print) IS - 0390-6078 (Linking) VI - 111 IP - 5 DP - 2026 May 1 TI - Lipid dysregulation after hematopoietic stem cell transplant. PG - 1634-1645 LID - 10.3324/haematol.2025.288933 [doi] AB - Transplant-associated thrombotic microangiopathy (TA-TMA) is a serious complication of allogeneic hematopoietic stem cell transplant (allo-HSCT), primarily driven by endothelial injury and complement activation. Statins, combined with other drugs, are commonly used as prophylaxis against endothelial injury in some parts of the world but their mechanism of action has not been clearly defined. We hypothesized that dysregulation of lipids, or their precursors, ceramides, might be an important mechanism of endothelial injury, and that statins might ameliorate that dysfunction. We measured plasma ceramide species at baseline and day 14 in pediatric and young adult allo-HSCT recipients. Ceramide species in general were increased in those who later developed endothelial injury, manifest as TA-TMA. These findings highlighted ceramides as markers of endothelial stress, prompting us to explore whether statin prophylaxis could favorably modulate lipid and ceramide pathways. A single-arm phase I trial of pravastatin prophylaxis was also performed in patients at elevated risk of endothelial injury due to high body mass index to assess lipid and ceramide modulation over time. Multiple ceramide species were elevated in patients who developed TA-TMA and showed strong correlations with ST2 but not with sC5b-9. While ceramides were associated with TA-TMA in univariate models, only ST2 remained significant in multivariable analysis. Addition of ceramide levels to ST2 only modestly improved prediction of later TA-TMA in Receiver Operating Characteristic (ROC) analysis. Pravastatin prophylaxis was associated with distinct shifts in lipoprotein and ceramide profiles, potentially reflecting modulation of endothelial function. Pravastatin may alter ceramide and lipoprotein pathways in a clinically meaningful way, contributing to their role in endothelial protection. FAU - Koo, Jane AU - Koo J AD - Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA; Department of Pediatrics, University of Cincinnati, Cincinnati OH. jane.koo@cchmc.org. FAU - Langenberg, Lucille AU - Langenberg L AD - Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA; Department of Pediatrics, University of Cincinnati, Cincinnati OH. FAU - Zhao, Xueheng AU - Zhao X AD - Department of Pediatrics, University of Cincinnati, Cincinnati OH USA; Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. FAU - Setchell, Kenneth R AU - Setchell KR AD - Department of Pediatrics, University of Cincinnati, Cincinnati OH USA; Division of Pathology and Laboratory Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. FAU - Lake, Kelly E AU - Lake KE AD - Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA; Department of Pediatrics, University of Cincinnati, Cincinnati OH. FAU - Luebbering, Nathan AU - Luebbering N AD - Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA; Department of Pediatrics, University of Cincinnati, Cincinnati OH. FAU - Walter, Ellen AU - Walter E AD - Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA; Department of Pediatrics, University of Cincinnati, Cincinnati OH. FAU - Lane, Adam AU - Lane A AD - Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA; Department of Pediatrics, University of Cincinnati, Cincinnati OH. FAU - Myers, Kasiani C AU - Myers KC AD - Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA; Department of Pediatrics, University of Cincinnati, Cincinnati OH. FAU - Reynaud, Damien AU - Reynaud D AD - Department of Pediatrics, University of Cincinnati, Cincinnati OH USA; Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH. FAU - Sabulski, Anthony AU - Sabulski A AD - Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA; Department of Pediatrics, University of Cincinnati, Cincinnati OH. FAU - Teusink-Cross, Ashley AU - Teusink-Cross A AD - Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA; Department of Pediatrics, University of Cincinnati, Cincinnati OH. FAU - Jodele, Sonata AU - Jodele S AD - Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA; Department of Pediatrics, University of Cincinnati, Cincinnati OH. FAU - Davies, Stella M AU - Davies SM AD - Division of Bone Marrow Transplantation and Immune Deficiency, Cincinnati Children's Hospital Medical Center, Cincinnati OH USA; Department of Pediatrics, University of Cincinnati, Cincinnati OH. LA - eng GR - R01 DK133145/DK/NIDDK NIH HHS/United States PT - Clinical Trial, Phase I PT - Journal Article DEP - 20251224 PL - Italy TA - Haematologica JT - Haematologica JID - 0417435 RN - 0 (Ceramides) RN - 0 (Biomarkers) RN - KXO2KT9N0G (Pravastatin) RN - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors) RN - 0 (Lipids) SB - IM MH - Humans MH - *Hematopoietic Stem Cell Transplantation/adverse effects MH - Male MH - Female MH - *Ceramides/blood MH - Adolescent MH - Child MH - Young Adult MH - Adult MH - *Thrombotic Microangiopathies/etiology/blood/prevention & control MH - Child, Preschool MH - Biomarkers MH - *Lipid Metabolism/drug effects MH - Pravastatin/therapeutic use MH - Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use MH - *Lipids/blood PMC - PMC13136832 EDAT- 2025/12/24 07:43 MHDA- 2026/05/04 12:33 PMCR- 2025/12/24 CRDT- 2025/12/24 03:43 PHST- 2025/08/12 00:00 [received] PHST- 2026/05/04 12:33 [medline] PHST- 2025/12/24 07:43 [pubmed] PHST- 2025/12/24 03:43 [entrez] PHST- 2025/12/24 00:00 [pmc-release] AID - 10.3324/haematol.2025.288933 [doi] PST - ppublish SO - Haematologica. 2026 May 1;111(5):1634-1645. doi: 10.3324/haematol.2025.288933. Epub 2025 Dec 24. PMID- 41437297 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251224 LR - 20251227 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 13 IP - 1 DP - 2025 Dec 23 TI - Childhood traumatic experiences and addiction-like eating behaviors: the mediating roles of attachment, mentalization, and emotional eating. PG - 288 LID - 10.1186/s40337-025-01473-x [doi] LID - 288 AB - INTRODUCTION: Childhood traumatic experiences (CTEs) represent a significant vulnerability factor for addiction-like eating behaviors, yet the underlying developmental pathways remain poorly understood. According to infancy research and attachment theory, this study tested a comprehensive mediation model examining how CTEs contribute to addiction-like eating patterns (i.e., appetite drive and low diet control) through attachment insecurity, impaired reflective functioning, and emotional eating. METHOD: A cross-sectional study was conducted on a conventional non-clinical sample 1,014 Italian adults. Participants completed a set of validated and standardized scales. Structural equation modeling with latent variables and bootstrap resampling (10,000 iterations) was employed to test the hypothesized model. RESULTS: The model demonstrated adequate fit and supported all hypotheses. CTEs significantly predicted both attachment anxiety, attachment avoidance, and impaired reflective functioning. Attachment anxiety, but not avoidance, mediated the relationship between CTEs and impaired reflective functioning. Also, impaired reflective functioning significantly predicted emotional eating, which in turn predicted both appetite drive and low dietary control. The complete mediation pathway was statistically significant, explaining 53.5% of variance in appetite drive and 20.6% in dietary control. DISCUSSION: These findings provide the first empirical support for a trauma-based developmental model of addiction-like eating behaviors. The results highlight the central role of attachment anxiety and impaired reflective functioning in linking early relational trauma to emotional eating and food addiction-like patterns. Clinical implications suggest that mentalization-based interventions targeting attachment insecurity and emotion regulation may be particularly beneficial for individuals with trauma histories and problematic eating behaviors. CI - (c) 2025. The Author(s). FAU - Rossi, Alessandro Alberto AU - Rossi AA AUID- ORCID: 0000-0001-7000-5999 AD - Department of Philosophy, Sociology, Education, and Applied Psychology, Section of Applied Psychology, University of Padova, Padova, Italy. a.rossi@unipd.it. AD - Center for Intervention and Research on Family Studies-CIRF-Department of Philosophy, Sociology, Education, and Applied Psychology, Section of Applied Psychology, University of Padova, Padova, Italy. a.rossi@unipd.it. FAU - Mannarini, Stefania AU - Mannarini S AUID- ORCID: 0000-0002-8446-785X AD - Department of Philosophy, Sociology, Education, and Applied Psychology, Section of Applied Psychology, University of Padova, Padova, Italy. AD - Center for Intervention and Research on Family Studies-CIRF-Department of Philosophy, Sociology, Education, and Applied Psychology, Section of Applied Psychology, University of Padova, Padova, Italy. LA - eng PT - Journal Article DEP - 20251223 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC12723922 OAB - People who experienced difficult or harmful relationships with caregivers during childhood, such as abuse or neglect, are more likely to develop unhealthy eating patterns that resemble addiction. This study explored how this happens. We surveyed over 1,000 Italian adults and found that childhood trauma creates a chain reaction. First, these early negative experiences often lead people to feel anxious in their relationships and struggle to understand their own emotions and those of others. When people cannot recognize or manage their feelings well, they may turn to food for comfort, eating to cope with stress rather than hunger. Over time, this emotional eating can develop into addiction-like behaviors, including intense cravings for certain foods and difficulty controlling how much they eat. Our findings suggest that treating problematic eating patterns requires addressing more than just food and diet. Therapies that help people better understand their emotions, improve their relationships, and develop healthier ways to manage stress may be especially helpful for those who experienced childhood trauma. Understanding these connections can lead to more effective support for people struggling with food-related difficulties. OABL- eng OTO - NOTNLM OT - Addiction-like eating behaviors OT - Attachment anxiety OT - Childhood traumatic experiences OT - Eating addiction OT - Food addiction OT - Low diet control OT - Mentalization COIS- Declarations. Ethics approval and consent to participate: Ethics approval was provided by the Ethics Committee of the University of Padua (n degrees 547-a). Informed consent was obtained from all participants. All procedures adhered to the relevant guidelines and regulations. The study described has been carried out in accordance with the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/24 07:43 MHDA- 2025/12/24 07:44 PMCR- 2025/12/23 CRDT- 2025/12/24 00:29 PHST- 2025/08/08 00:00 [received] PHST- 2025/11/16 00:00 [accepted] PHST- 2025/12/24 07:44 [medline] PHST- 2025/12/24 07:43 [pubmed] PHST- 2025/12/24 00:29 [entrez] PHST- 2025/12/23 00:00 [pmc-release] AID - 10.1186/s40337-025-01473-x [pii] AID - 1473 [pii] AID - 10.1186/s40337-025-01473-x [doi] PST - epublish SO - J Eat Disord. 2025 Dec 23;13(1):288. doi: 10.1186/s40337-025-01473-x. PMID- 41437006 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Dec 23 TI - Implementing a family-based intervention to promote healthy family routines in deprived neighborhoods - a feasibility study from Bremen, Germany. PG - 4344 LID - 10.1186/s12889-025-25532-9 [doi] LID - 4344 AB - BACKGROUND: The prevalence of overweight and obesity among children in Europe is high. Particularly ethnic minority and low-income families are at increased risk. This highlights the need for effective family-based interventions addressing multiple obesity-related behaviors tailored to socially deprived families. Addressing this issue, our study aimed to adapt the North American 'Healthy Habits, Happy Homes' program to socially deprived neighborhoods in Bremen, Germany, and to test the feasibility of its implementation by using the RE-AIM model. METHODS: This single-arm intervention study was conducted between 2022 and 2023, including a process evaluation and a pre-post outcome assessment. Families with children aged 3-10 received 4 intervention visits from a health educator over a period of 3-9 months. The implementation fidelity was assessed via an intervention logbook. The acceptability and maintenance of intervention was assessed via feedback questionnaire filled out by parents and through qualitative data collected from parents, intervention staff and local stakeholders. The pre-post outcome assessment was conducted to evaluate its acceptability and to estimate changes in weight status of parents and children, and the children's dietary habits, physical activity, sleep duration, screen time and behavioral problems. RESULTS: In total, 23 caregivers and 33 children participated in the intervention study, and 87% of the families reported at least one indicator of social deprivation. Recruitment proved to be challenging; active recruitment methods, i.e. approaching families personally, were more effective than passive ones. The program implementation demonstrated good fidelity and acceptability. Language barriers were perceived as obstacles in program delivery. 78% of the families completed the outcome measurement. Descriptive analysis revealed positive trends over time in increased physical activity, reduced screen time, and behavioral problems, but no changes in BMI, dietary habits, or sleep duration. Stakeholders recommended integrating the intervention into existing structures like kindergartens for long-term implementation. CONCLUSION: This study highlights the program's acceptability and potential benefits for families in deprived neighborhoods of a German city, while acknowledging recruitment challenges. Further adaptations are needed to address barriers and integrate the intervention into wider community efforts to combat childhood obesity. FAU - Schepan, Marie Lisanne AU - Schepan ML AD - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstrasse 30, 28359, Bremen, Germany. schepan@leibniz-bips.de. AD - University of Bremen, Bibliothekstrasse 1, Bremen, 28359, Germany. schepan@leibniz-bips.de. FAU - Ahrens, Wolfgang AU - Ahrens W AD - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstrasse 30, 28359, Bremen, Germany. FAU - Altgeld, Thomas AU - Altgeld T AD - State Association for Health and Academy for Social Medicine Lower Saxony Bremen e. V., Schillerstr. 32, 30159, Hannover, Germany. FAU - Busse, Heide AU - Busse H AD - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstrasse 30, 28359, Bremen, Germany. FAU - Haines, Jess AU - Haines J AD - University of Guelph, 50 Stone Road East, Guelph, ON, N1G 2W1, Canada. FAU - Rataj, Elisabeth AU - Rataj E AD - State Association for Health and Academy for Social Medicine Lower Saxony Bremen e. V., Schillerstr. 32, 30159, Hannover, Germany. FAU - Swenne, Annika AU - Swenne A AD - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstrasse 30, 28359, Bremen, Germany. FAU - Wolters, Maike AU - Wolters M AD - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstrasse 30, 28359, Bremen, Germany. FAU - Zeeb, Hajo AU - Zeeb H AD - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstrasse 30, 28359, Bremen, Germany. FAU - Brand, Tilman AU - Brand T AD - Leibniz Institute for Prevention Research and Epidemiology - BIPS, Achterstrasse 30, 28359, Bremen, Germany. LA - eng PT - Journal Article DEP - 20251223 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Feasibility Studies MH - Germany MH - Child MH - Male MH - Female MH - Child, Preschool MH - *Health Promotion/methods/organization & administration MH - *Pediatric Obesity/prevention & control MH - *Poverty Areas MH - Program Evaluation PMC - PMC12751738 OTO - NOTNLM OT - Childhood obesity OT - Family-based interventions OT - Inequality OT - Obesity prevention COIS- Declarations. Ethics approval and consent to participate: This study was approved by the ethics committee of the University of Bremen, Germany (2021-18 and 2022-05) and all participants provided informed consent. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/24 00:33 MHDA- 2026/06/27 12:36 PMCR- 2025/12/23 CRDT- 2025/12/23 23:56 PHST- 2024/05/17 00:00 [received] PHST- 2025/11/02 00:00 [accepted] PHST- 2026/06/27 12:36 [medline] PHST- 2025/12/24 00:33 [pubmed] PHST- 2025/12/23 23:56 [entrez] PHST- 2025/12/23 00:00 [pmc-release] AID - 10.1186/s12889-025-25532-9 [pii] AID - 25532 [pii] AID - 10.1186/s12889-025-25532-9 [doi] PST - epublish SO - BMC Public Health. 2025 Dec 23;25(1):4344. doi: 10.1186/s12889-025-25532-9. PMID- 41435761 OWN - NLM STAT- MEDLINE DCOM- 20260503 LR - 20260605 IS - 1536-4844 (Electronic) IS - 1078-0998 (Linking) VI - 32 IP - 5 DP - 2026 May 1 TI - Tonsillectomy and the Risk of Inflammatory Bowel Disease: A Retrospective Cohort Study Using Real-World US Data. PG - 884-892 LID - 10.1093/ibd/izaf306 [doi] AB - IMPORTANCE: Inflammatory bowel disease (IBD) encompasses chronic inflammatory conditions primarily affecting the small intestine and colon. Ulcerative colitis (UC) and Crohn's disease (CD) involve dysregulated immune responses to intestinal microbiota, influenced by genetic predisposition, environmental factors, and gut barrier dysfunction. This retrospective cohort study was carried out to understand the relationship between immune-modulating surgeries like tonsillectomy and the development of IBD. OBJECTIVE: To evaluate the association between tonsillectomy and the risk of developing IBD. Design, Setting, and Participants: This retrospective cohort study used the TriNetX research network, a large US-based collaborative platform, to identify 124,132,724 individuals from 2005 to 2023. After applying inclusion criteria, 1,420,302 matched participants (tonsillectomy vs nontonsillectomy) were selected using 1:1 propensity score matching. EXPOSURE: Tonsillectomy. MAIN OUTCOME AND MEASURE: The primary outcome was the incidence of IBD, including CD and UC, defined by validated diagnostic codes. Propensity score matching (PSM) (1:1) was used matching age, sex, race, body mass index, socioeconomic status, healthcare utilization, comorbidities, medications, and Creactive protein levels. Subgroup and sensitivity analyses were conducted to estimate the adjusted hazard ratio (HR) between surgical intervention and IBD risk. RESULTS: After matching, baseline characteristics were well balanced between surgical and nonsurgical groups. Tonsillectomy was associated with a significantly increased risk of developing IBD (HR, 1.30; 95% CI, 1.14-1.47). Elevated risks were observed for both CD (HR, 1.37) and UC (HR, 1.29). Increased IBD risk was consistent across demographic subgroups. Sensitivity analyses confirmed the robustness of these findings across varying follow-up periods. CONCLUSIONS AND RELEVANCE: This study highlights a significant association between tonsillectomy and increased risk of developing IBD. These observations underscore the potential role of tonsillectomy in influencing long-term gastrointestinal health, warranting further investigation into underlying mechanisms and preventative strategies. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of Crohn's & Colitis Foundation. All rights reserved. For commercial re-use, please contact reprints@oup.com for reprints and translation rights for reprints. All other permissions can be obtained through our RightsLink service via the Permissions link on the article page on our site-for further information please contact journals.permissions@oup.com. FAU - Guo, Jyun-Yi AU - Guo JY AUID- ORCID: 0009-0007-0021-6521 AD - Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan. AD - Division of Pediatric Gastroenterology, Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan. FAU - Wu, Meng-Che AU - Wu MC AD - Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan. AD - Division of Pediatric Gastroenterology, Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan. AD - Department of Post-Baccalaureate Medicine, College of Medicine, National Chung Hsing University, Taichung, Taiwan. AD - School of Medicine, Chung Shan Medical University, Taichung, Taiwan. FAU - Wang, Yu-Hsun AU - Wang YH AD - Department of Medical Research, Chung Shan Medical University Hospital, Taichung, Taiwan. FAU - Lin, Chieh-Chung AU - Lin CC AD - Division of Pediatric Gastroenterology, Children's Medical Center, Taichung Veterans General Hospital, Taichung, Taiwan. AD - Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan. FAU - Wei, James Cheng-Chung AU - Wei JC AUID- ORCID: 0000-0002-1235-0679 AD - Institute of Medicine, College of Medicine, Chung Shan Medical University, Taichung, Taiwan. AD - Department of Allergy, Immunology & Rheumatology, Chung Shan Medical University Hospital, Taichung, Taiwan. AD - Office of Research and Development, Asia University, Taichung, Taiwan. AD - Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan. LA - eng PT - Journal Article PL - England TA - Inflamm Bowel Dis JT - Inflammatory bowel diseases JID - 9508162 SB - IM MH - Humans MH - *Tonsillectomy/adverse effects/statistics & numerical data MH - Retrospective Studies MH - Male MH - Female MH - Adult MH - United States/epidemiology MH - Risk Factors MH - Middle Aged MH - Incidence MH - *Crohn Disease/epidemiology/etiology MH - *Colitis, Ulcerative/epidemiology/etiology MH - *Inflammatory Bowel Diseases/epidemiology/etiology MH - Propensity Score MH - Young Adult MH - Adolescent MH - Follow-Up Studies OAB - Tonsillectomy is associated with a significantly increased risk of developing inflammatory bowel disease, including Crohn's disease and ulcerative colitis. This large cohort study highlights the potential long-term gastrointestinal impact of immune-modulating surgeries like tonsillectomy. OABL- eng OTO - NOTNLM OT - Crohn's disease OT - inflammatory bowel disease OT - tonsillectomy OT - ulcerative colitis EDAT- 2025/12/24 00:33 MHDA- 2026/05/04 00:31 CRDT- 2025/12/23 18:12 PHST- 2025/04/15 00:00 [received] PHST- 2025/11/15 00:00 [accepted] PHST- 2026/05/04 00:31 [medline] PHST- 2025/12/24 00:33 [pubmed] PHST- 2025/12/23 18:12 [entrez] AID - 8403444 [pii] AID - 10.1093/ibd/izaf306 [doi] PST - ppublish SO - Inflamm Bowel Dis. 2026 May 1;32(5):884-892. doi: 10.1093/ibd/izaf306. PMID- 41435525 OWN - NLM STAT- MEDLINE DCOM- 20260126 LR - 20260126 IS - 1873-264X (Electronic) IS - 0731-7085 (Linking) VI - 271 DP - 2026 Apr 15 TI - Development and validation of a rapid LC-MS/MS method for methylphenidate, atomoxetine, and their metabolites with application to pediatric pharmacokinetics. PG - 117321 LID - S0731-7085(25)00662-4 [pii] LID - 10.1016/j.jpba.2025.117321 [doi] AB - Therapeutic drug monitoring of attention-deficit/hyperactivity disorder (ADHD) pharmacotherapy is challenged by substantial interindividual variability and the lack of rapid, multiplex analytical platforms. We developed and validated a fast, integrated 5-minute LC-MS/MS assay for the simultaneous quantification of stimulant (methylphenidate, ritalinic acid) and non-stimulant (atomoxetine, 4-hydroxy-atomoxetine) ADHD medications in human serum. The method employs a single-step protein precipitation and requires only 200 microL of serum. Validation demonstrated excellent linearity, precision, accuracy, minimal matrix effects, and robust analyte stability in accordance with FDA and CLSI guidelines. Application to pediatric ADHD patients revealed formulation- and dose-dependent concentration differences for methylphenidate and atomoxetine, along with strong parent-metabolite correlations. No significant associations were observed with age, sex, or body mass index. This rapid and reliable LC-MS/MS platform supports clinically actionable therapeutic drug monitoring and provides a practical framework for personalized ADHD treatment. CI - Copyright (c) 2025. Published by Elsevier B.V. FAU - Eryavuz Onmaz, Duygu AU - Eryavuz Onmaz D AD - Department of Biochemistry, Bandirma Onyedi Eylul University Faculty of Medicine, Bandirma, Turkey. Electronic address: donmaz@bandirma.edu.tr. FAU - Kuz, Merve AU - Kuz M AD - Department of Child and Adolescent Psychiatry, Diamind Mental Academy, Konya, Turkey. FAU - Cetin, Fatih Hilmi AU - Cetin FH AD - Department of Child and Adolescent Psychiatry, Diamind Mental Academy, Konya, Turkey. FAU - Ucar, Halit Necmi AU - Ucar HN AD - Department of Child and Adolescent Psychiatry, Diamind Mental Academy, Konya, Turkey. FAU - Turkoglu, Serhat AU - Turkoglu S AD - Department of Child and Adolescent Psychiatry, Selcuk University Faculty of Medicine, Konya, Turkey. FAU - Coban, Rabia AU - Coban R AD - Department of Biochemistry, Selcuk University Faculty of Medicine, Konya, Turkey. FAU - Unlu, Ali AU - Unlu A AD - Department of Biochemistry, Selcuk University Faculty of Medicine, Konya, Turkey. LA - eng PT - Journal Article PT - Validation Study DEP - 20251219 PL - England TA - J Pharm Biomed Anal JT - Journal of pharmaceutical and biomedical analysis JID - 8309336 RN - 207ZZ9QZ49 (Methylphenidate) RN - 57WVB6I2W0 (Atomoxetine Hydrochloride) RN - 0 (Central Nervous System Stimulants) SB - IM MH - *Methylphenidate/pharmacokinetics/blood MH - Humans MH - *Atomoxetine Hydrochloride/pharmacokinetics/blood/metabolism MH - *Tandem Mass Spectrometry/methods MH - Attention Deficit Disorder with Hyperactivity/drug therapy/blood MH - Child MH - Drug Monitoring/methods MH - Male MH - *Central Nervous System Stimulants/pharmacokinetics/blood MH - Female MH - Chromatography, Liquid/methods MH - Reproducibility of Results MH - Adolescent MH - Liquid Chromatography-Mass Spectrometry OTO - NOTNLM OT - Atomoxetine OT - LC-MS/MS OT - Methylphenidate OT - Pediatric ADHD OT - Pharmacokinetics OT - Therapeutic drug monitoring COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/24 00:34 MHDA- 2026/01/27 00:52 CRDT- 2025/12/23 18:03 PHST- 2025/11/05 00:00 [received] PHST- 2025/12/12 00:00 [revised] PHST- 2025/12/19 00:00 [accepted] PHST- 2026/01/27 00:52 [medline] PHST- 2025/12/24 00:34 [pubmed] PHST- 2025/12/23 18:03 [entrez] AID - S0731-7085(25)00662-4 [pii] AID - 10.1016/j.jpba.2025.117321 [doi] PST - ppublish SO - J Pharm Biomed Anal. 2026 Apr 15;271:117321. doi: 10.1016/j.jpba.2025.117321. Epub 2025 Dec 19. PMID- 41432743 OWN - NLM STAT- MEDLINE DCOM- 20260306 LR - 20261009 IS - 1432-1998 (Electronic) IS - 0301-0449 (Linking) VI - 56 IP - 3 DP - 2026 Mar TI - Exploring the association between BMI and liver fat in children: a study using ultrasound-derived fat fraction (UDFF). PG - 575-581 LID - 10.1007/s00247-025-06493-y [doi] AB - BACKGROUND: Childhood obesity is rising worldwide, leading to an increased prevalence of metabolic dysfunction-associated steatotic liver disease, the most common pediatric liver disease. Ultrasound-derived fat fraction (UDFF) is a recently developed technique for quantifying hepatic fat that has been validated in children, providing a rapid, reliable, and non-invasive alternative to conventional imaging. OBJECTIVE: To evaluate the association between weight status, expressed as body mass index (BMI) z-score, and UDFF in a pediatric population without underlying liver disease. MATERIALS AND METHODS: Abdominal ultrasounds including a UDFF measurement in patients without liver disease were retrospectively evaluated. We calculated the BMI z-score for all patients and classified them as normal weight (zBMI) or overweight (zBMI>/=1). UDFF values were compared across zBMI categories, sex and ethnicity (Hispanic/Latino or non-Hispanic/non-Latino), using chi-square tests (P<0.05). Pearson's correlation was used to assess the relationship between continuous UDFF values and zBMI. Logistic regression analyses were performed to assess associations between elevated UDFF (>6%) and adiposity markers (zBMI and ultrasound-measured abdominal wall thickness (AWT)), as well as ethnicity. RESULTS: Of 223 subjects, 93 (41 males/52 females, mean age of 8.2 years) met the inclusion criteria. In the normal-weight population (n=46), 41 (89.1%) had normal UDFF, and 5 (10.9%) had elevated UDFF. In the overweight group (n =47), 29 (61.7%) had normal UDFF and 18 (38.3%) had elevated UDFF. UDFF values showed a positive correlation with zBMI, and higher zBMI increased the odds of elevated UDFF. In the multivariable model including zBMI, AWT, and ethnicity, ultrasound-measured abdominal wall thickness was the strongest predictor of elevated UDFF. CONCLUSION: BMI z-score was positively associated with hepatic fat content and with higher odds of elevated UDFF. When multiple factors were considered together, ultrasound-measured abdominal wall thickness showed the strongest independent association with elevated UDFF supporting the central role of adiposity in pediatric hepatic fat accumulation. UDFF may serve as a valuable complement to routine clinical markers, using zBMI, for early identification of children with hepatic steatosis. Larger prospective studies are needed to define its role in clinical practice. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Moeremans, Marine AU - Moeremans M AD - Department of Pediatric Radiology, Stanford University, Lucile Packard Children's Hospital, 725 Welch Rd, Palo Alto, CA 94304, USA. marine.moeremans@hotmail.com. FAU - Barth, Richard A AU - Barth RA AD - Department of Pediatric Radiology, Stanford University, Lucile Packard Children's Hospital, 725 Welch Rd, Palo Alto, CA 94304, USA. FAU - Zalcman, Max AU - Zalcman M AD - Department of Pediatric Radiology, Queen Fabiola Children's University Hospital, Brussels, Belgium. FAU - Rubesova, Erika AU - Rubesova E AD - Department of Pediatric Radiology, Stanford University, Lucile Packard Children's Hospital, 725 Welch Rd, Palo Alto, CA 94304, USA. rubesova@stanford.edu. LA - eng PT - Journal Article DEP - 20251223 PL - Germany TA - Pediatr Radiol JT - Pediatric radiology JID - 0365332 SB - IM MH - Humans MH - Female MH - Male MH - Child MH - Ultrasonography/methods MH - *Body Mass Index MH - Retrospective Studies MH - *Pediatric Obesity/diagnostic imaging MH - Adolescent MH - Child, Preschool MH - *Liver/diagnostic imaging MH - *Fatty Liver/diagnostic imaging MH - *Adipose Tissue/diagnostic imaging OTO - NOTNLM OT - Childhood obesity OT - Steatosis OT - UDFF COIS- Declarations. Conflicts of interest: The authors declare no competing interests. EDAT- 2025/12/23 12:47 MHDA- 2026/03/07 01:37 CRDT- 2025/12/23 11:13 PHST- 2025/08/30 00:00 [received] PHST- 2025/12/02 00:00 [accepted] PHST- 2025/11/30 00:00 [revised] PHST- 2026/03/07 01:37 [medline] PHST- 2025/12/23 12:47 [pubmed] PHST- 2025/12/23 11:13 [entrez] AID - 10.1007/s00247-025-06493-y [pii] AID - 10.1007/s00247-025-06493-y [doi] PST - ppublish SO - Pediatr Radiol. 2026 Mar;56(3):575-581. doi: 10.1007/s00247-025-06493-y. Epub 2025 Dec 23. PMID- 41432100 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20260813 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 82 IP - 3 DP - 2026 Mar TI - Fatigue in pediatric inflammatory bowel disease: Explained by transdiagnostic and disease-focused factors. PG - 699-707 LID - 10.1002/jpn3.70317 [doi] AB - OBJECTIVE: Fatigue is highly prevalent in children with inflammatory bowel disease (IBD), even during clinical remission. This suggests a role for transdiagnostic factors-lifestyle, psychological, and social influences not specific to the disease. This study aimed to assess the prevalence of severe fatigue in pediatric IBD and evaluate its associations with both IBD-focused and transdiagnostic factors. METHODS: Children with IBD ages 8-18 from the PROactive cohort completed the Pediatric Quality of Life Inventory-Multidimensional Fatigue Scale. IBD-focused clinical data were extracted from electronic health records. Transdiagnostic factors were assessed using validated patient-reported outcome measures. Associations with fatigue were examined using linear regression. RESULTS: Among 127 patients (mean age 14.9 +/- 2.7 years; 43% male), most were in clinical remission. One hundred six patients self-reported fatigue, and 99 parents reported their child's fatigue. Severe fatigue was self-reported by 29%. Of IBD-focused factors, only disease activity (beta = -0.40) and comorbidity (beta = -0.18) showed significant associations with fatigue. Of transdiagnostic factors, lower physical, emotional, and social functioning; poorer sleep quality; less physical activity; more pain, anxiety, and depressive symptoms; lower life satisfaction and self-rated health; and increased school absence and pressure were significantly associated with more fatigue. Backward selection retained only transdiagnostic factors in the multivariate model, which explained 78% of fatigue variance. CONCLUSION: Fatigue is common in children with IBD and is more strongly associated with transdiagnostic than disease-focused factors. These findings highlight the importance of integrative care strategies that address modifiable psychosocial and lifestyle domains to reduce fatigue and improve functioning in children with IBD. CI - (c) 2025 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Stutvoet, Maartje D AU - Stutvoet MD AUID- ORCID: 0000-0002-8857-7749 AD - Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. FAU - Vroegindeweij, Anouk AU - Vroegindeweij A AD - Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. FAU - Toonen, Tessa Z AU - Toonen TZ AD - Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands. FAU - Nap-Van der Vlist, Merel M AU - Nap-Van der Vlist MM AD - Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. FAU - Hoefnagels, Johanna W AU - Hoefnagels JW AD - Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. FAU - van den Berg, Anemone AU - van den Berg A AD - Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands. FAU - Nijhof, Sanne L AU - Nijhof SL AD - Department of Pediatrics, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. LA - eng GR - NWA.1292.19.226/Netherlands Organization for Scientific Research under the eHealth Junior consortium project/ PT - Journal Article DEP - 20251223 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM MH - Humans MH - Male MH - *Fatigue/epidemiology/etiology/psychology/diagnosis MH - Female MH - Child MH - Adolescent MH - *Inflammatory Bowel Diseases/complications/psychology MH - Quality of Life MH - Prevalence MH - Severity of Illness Index MH - Patient Reported Outcome Measures MH - Self Report PMC - PMC12964513 OTO - NOTNLM OT - Crohn's disease OT - child health OT - cohort studies OT - disease activity OT - ulcerative colitis COIS- The authors declare no conflicts of interest. EDAT- 2025/12/23 12:48 MHDA- 2026/03/07 16:11 PMCR- 2026/03/06 CRDT- 2025/12/23 06:13 PHST- 2025/11/18 00:00 [revised] PHST- 2025/07/22 00:00 [received] PHST- 2025/11/21 00:00 [accepted] PHST- 2026/03/07 16:11 [medline] PHST- 2025/12/23 12:48 [pubmed] PHST- 2025/12/23 06:13 [entrez] PHST- 2026/03/06 00:00 [pmc-release] AID - JPN370317 [pii] AID - 10.1002/jpn3.70317 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Mar;82(3):699-707. doi: 10.1002/jpn3.70317. Epub 2025 Dec 23. PMID- 41432023 OWN - NLM STAT- MEDLINE DCOM- 20260528 LR - 20260528 IS - 1553-3514 (Electronic) IS - 1553-3506 (Linking) VI - 33 IP - 3 DP - 2026 Jun TI - Artificial Intelligence-Based Prediction of Recurrence and Personalized Treatment Planning in Pediatric Pilonidal Sinus Disease. PG - 225-233 LID - 10.1177/15533506251411009 [doi] AB - PurposeThis study aimed to assess the feasibility of artificial intelligence (AI)-based models for predicting recurrence risk and supporting individualized treatment strategies in pediatric pilonidal sinus disease (PSD).MethodsClinical data from 242 pediatric PSD patients were retrospectively analyzed. Two machine learning (ML) models were developed: (1) a binary classifier for recurrence prediction and (2) a multiclass classifier for treatment modality selection. Model performance was evaluated using 5-fold cross-validation based on accuracy, area under the receiver operating characteristic curve (ROC-AUC), F1 score, and confusion matrix. Model interpretability was assessed using SHapley Additive exPlanations (SHAP) analysis to identify the most influential predictive features.ResultsAmong 242 patients, 59.1% underwent surgical excision (unroofing with secondary healing), 33.1% received crystallized phenol, and 7.8% were treated with silver nitrate. The overall recurrence rate was 5.7%, with no significant differences among treatment modalities. Longer healing duration, larger lesion size, higher body mass index (BMI), and an increased number of sinus tracts were associated with higher recurrence risk. SHAP analysis revealed that healing time, BMI, age, and the number of sinus tracts were the most influential predictors in both recurrence and treatment selection models.ConclusionAI-based predictive models can effectively estimate recurrence risk and assist in tailoring individualized management strategies for pediatric PSD. Further multicenter, prospective studies are warranted to validate these findings and support clinical integration of AI-assisted decision systems. FAU - Oztas, Tulin AU - Oztas T AUID- ORCID: 0000-0002-1010-3324 AD - Department of Pediatric Surgery, University of Health Sciences Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey. FAU - Cal, Suat AU - Cal S AD - Department of Pediatric Surgery, University of Health Sciences Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey. FAU - Akdeniz, Sevinc AU - Akdeniz S AD - Department of Pediatric Surgery, University of Health Sciences Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey. FAU - Tegin, Serdest AU - Tegin S AD - Department of Pediatric Surgery, University of Health Sciences Diyarbakir Gazi Yasargil Training and Research Hospital, Diyarbakir, Turkey. LA - eng PT - Evaluation Study PT - Journal Article DEP - 20251223 PL - United States TA - Surg Innov JT - Surgical innovation JID - 101233809 RN - 95IT3W8JZE (Silver Nitrate) RN - 339NCG44TV (Phenol) RN - 0 (Sclerosing Solutions) SB - IM MH - Risk Assessment/methods MH - *Pilonidal Sinus/drug therapy/epidemiology/surgery MH - Recurrence MH - Feasibility Studies MH - ROC Curve MH - Silver Nitrate/administration & dosage MH - Phenol/administration & dosage MH - Sclerosing Solutions/administration & dosage MH - Risk Factors MH - *Clinical Decision-Making/methods MH - Retrospective Studies MH - Time Factors MH - Age Factors MH - Body Mass Index MH - Cross-Sectional Studies MH - Follow-Up Studies MH - *Machine Learning MH - Random Forest MH - Boosting Machine Learning Algorithms MH - Humans MH - Male MH - Female MH - Child MH - Adolescent OTO - NOTNLM OT - artificial intelligence OT - machine learning OT - personalized treatment OT - pilonidal sinus disease OT - recurrence prediction COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/12/23 07:47 MHDA- 2026/05/25 06:31 CRDT- 2025/12/23 05:42 PHST- 2026/05/25 06:31 [medline] PHST- 2025/12/23 07:47 [pubmed] PHST- 2025/12/23 05:42 [entrez] AID - 10.1177/15533506251411009 [doi] PST - ppublish SO - Surg Innov. 2026 Jun;33(3):225-233. doi: 10.1177/15533506251411009. Epub 2025 Dec 23. PMID- 41431904 OWN - NLM STAT- MEDLINE DCOM- 20251223 LR - 20251223 IS - 1319-2442 (Print) IS - 1319-2442 (Linking) VI - 36 IP - 1-6 DP - 2025 Jan 1 TI - Can a Cardiovascular Scoring System be Used to Determine Cardiovascular Disease in Pediatric Dialysis Patients? PG - 26-33 LID - 10.4103/sjkdt.sjkdt_501_21 [doi] AB - We created a two scoring systems for pediatric dialysis patients to determine the presence of cardiovascular disease (CVD) which are referred to as (CVDS)-1 and CVDS-2. We included 25 patients on hemodialysis (n = 19) and peritoneal dialysis (n = 6). CVDS-1 and CVDS-2 use multiple parameters, to determine the presence of CVD in pediatric dialysis patients. The scoring systems include renal pathology, nutrition, dialysis adequacy, residual urine output, protein catabolism, dialysis modality and some laboratory values. CVD evaluations included the left ventricular mass index, pulse wave velocity and carotid intima-media thickness measurements. The mean age was 11.1 +/- 6.51 years, and the male-female ratio was 14:11. Patients on peritoneal dialysis had higher serum levels of calcium x phosphorus product and diastolic blood pressure (P = 0.013 and P = 0.006, respectively). We did not find any significant correlation between peritoneal dialysis and hemodialysis patients in the CVDS-1 and CVDS-2 scores (P >0.005). The CVDS-1 system had a sensitivity of 90% and a specificity 80%. The CVDS-2 system had a sensitivity of 90% and a specificity 66%. Additionally, the area under the receiver operating characteristic curve of CVDS-1 was 0.913 (95% confidence interval (CI) = 0.80-1.00, P <0.001) for a diagnosis of CVD and that of CVDS-2 was 0.86 (95% CI = 0.72-1.00, P <0.001). We believe that CVDS-1 will be more successful in determining the presence of CVD with the biochemical parameters we use in clinical practice on a monthly basis. CI - Copyright (c) 2025 Saudi Journal of Kidney Diseases and Transplantation. FAU - Tuncay, Secil Conkar AU - Tuncay SC AD - Department of Pediatric Nephrology, Ege University, Faculty of Medicine, Izmir, Turkey. FAU - Keskinoglu, A AU - Keskinoglu A AD - Department of Pediatric Nephrology, Ege University, Faculty of Medicine, Izmir, Turkey. FAU - Bulut, I K AU - Bulut IK AD - Department of Pediatric Nephrology, Ege University, Faculty of Medicine, Izmir, Turkey. FAU - Levent, E AU - Levent E AD - Department of Pediatric Cardiology, Ege University, Faculty of Medicine, Izmir, Turkey. FAU - Hakverdi, G AU - Hakverdi G AD - Department of Biostatistics and Medical Informatics, Ege University, Faculty of Medicine, Izmir, Turkey. FAU - Kabasakal, C AU - Kabasakal C AD - Department of Pediatric Nephrology, Ege University, Faculty of Medicine, Izmir, Turkey. LA - eng PT - Journal Article DEP - 20251223 PL - Saudi Arabia TA - Saudi J Kidney Dis Transpl JT - Saudi journal of kidney diseases and transplantation : an official publication of the Saudi Center for Organ Transplantation, Saudi Arabia JID - 9436968 RN - 0 (Biomarkers) SB - IM MH - Humans MH - Male MH - Female MH - Child MH - *Cardiovascular Diseases/diagnosis/physiopathology/etiology MH - *Renal Dialysis/adverse effects MH - Adolescent MH - *Peritoneal Dialysis/adverse effects MH - Predictive Value of Tests MH - Carotid Intima-Media Thickness MH - Pulse Wave Analysis MH - Heart Disease Risk Factors MH - Age Factors MH - ROC Curve MH - Risk Assessment MH - Biomarkers/blood EDAT- 2025/12/23 07:47 MHDA- 2025/12/23 07:48 CRDT- 2025/12/23 05:03 PHST- 2025/12/23 07:48 [medline] PHST- 2025/12/23 07:47 [pubmed] PHST- 2025/12/23 05:03 [entrez] AID - 00936703-202501000-00004 [pii] AID - 10.4103/sjkdt.sjkdt_501_21 [doi] PST - ppublish SO - Saudi J Kidney Dis Transpl. 2025 Jan 1;36(1-6):26-33. doi: 10.4103/sjkdt.sjkdt_501_21. Epub 2025 Dec 23. PMID- 41431034 OWN - NLM STAT- MEDLINE DCOM- 20251223 LR - 20260523 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 104 IP - 51 DP - 2025 Dec 19 TI - A nomogram to predict large-for-gestational-age in term newborns: A retrospective single-center study. PG - e46580 LID - 10.1097/MD.0000000000046580 [doi] LID - e46580 AB - This study aims to build and validate a nomogram for large-for-gestational-age (LGA) prediction in full-term (37-41 weeks of gestation) newborns. This retrospective single-center study included consecutive full-term deliveries (37-41 weeks' gestation) at Yuyao People's Hospital of Zhejiang Province from January to December 2021. Participants were randomly assigned (7:3) to training and validation sets. The current study included 1481 deliveries (training n = 1017; validation n = 464). Gestational age (odds ratio [OR] = 1.32, 95% confidence interval [CI]: 1.13-1.54), gestational weight gain (OR = 1.07, 95% CI: 1.03-1.12), symphysis-fundal height (OR = 1.14, 95% CI: 1.03-1.27), fetal abdominal circumference (OR = 1.10, 95% CI: 1.09-1.12), triglycerides (OR = 1.49, 95% CI: 1.08-2.05), gestational diabetes mellitus (OR = 2.05, 95% CI: 1.33-3.14), and pre-pregnancy body mass index < 18.5 (OR = 0.48, 95% CI: 0.28-0.81) had independent associations with LGA. A nomogram was developed, and receiver operating characteristic curves had areas under the curves of 0.846 (95% CI: 0.821-0.871) and 0.802 (95% CI: 0.761-0.842) in the training and validation sets, respectively. Seven factors were independently associated with LGA. A nomogram was developed and showed favorable predictive performance. CI - Copyright (c) 2025 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Wu, Yingyun AU - Wu Y AD - Department of Obstetrics and Gynecology, The Affiliated Yangming Hospital of Ningbo University (Yuyao People's Hospital of Zhejiang Province), Yuyao, China. FAU - Ma, Jianting AU - Ma J AUID- ORCID: 0000-0003-4978-7337 LA - eng GR - No. 2021KY1073/Medical and Health Science and Technology Planned Project of Zhejiang Province/ PT - Journal Article PT - Observational Study PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Humans MH - *Nomograms MH - Retrospective Studies MH - Female MH - Infant, Newborn MH - Pregnancy MH - Gestational Age MH - Male MH - Adult MH - *Birth Weight MH - *Fetal Macrosomia/diagnosis/epidemiology MH - China/epidemiology MH - ROC Curve MH - Body Mass Index MH - Gestational Weight Gain PMC - PMC12727380 OTO - NOTNLM OT - large-for-gestational-age OT - newborn OT - nomogram OT - risk factor COIS- The authors have no conflicts of interest to disclose. EDAT- 2025/12/23 07:47 MHDA- 2025/12/23 07:48 PMCR- 2025/12/19 CRDT- 2025/12/23 01:04 PHST- 2024/12/20 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2025/12/23 07:48 [medline] PHST- 2025/12/23 07:47 [pubmed] PHST- 2025/12/23 01:04 [entrez] PHST- 2025/12/19 00:00 [pmc-release] AID - 00005792-202512190-00075 [pii] AID - MD-D-24-16297 [pii] AID - 10.1097/MD.0000000000046580 [doi] PST - ppublish SO - Medicine (Baltimore). 2025 Dec 19;104(51):e46580. doi: 10.1097/MD.0000000000046580. PMID- 41431029 OWN - NLM STAT- MEDLINE DCOM- 20251223 LR - 20260523 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 104 IP - 51 DP - 2025 Dec 19 TI - Analysis of risk factors for knee cartilage damage in patients with anterior cruciate ligament rupture. PG - e46103 LID - 10.1097/MD.0000000000046103 [doi] LID - e46103 AB - This retrospective study evaluated risk factors for concomitant cartilage damage in patients with anterior cruciate ligament (ACL) rupture treated between 1 January 2021 and 31 December 2024. Eligible adults (18-60 years) had ACL rupture confirmed by magnetic resonance imaging (MRI) and/or arthroscopy and complete clinical, imaging, and intraoperative data. Patients were stratified into a cartilage damage group (n = 61) and a non-damage group (n = 89). Demographic and injury-related variables were compared, and multivariable logistic regression identified independent associations; diagnostic performance was assessed using receiver operating characteristic (ROC) curves and area under the curve (AUC). Age and sex were comparable between groups. Cartilage damage was associated with higher body mass index (BMI), more sprain episodes, longer injury-to-evaluation time, and markedly higher rates of meniscal injury. In adjusted analyses, BMI > 22.9 kg/m(2) (odds ratio [OR] 1.13; 95% confidence interval [CI] 1.02-1.25), meniscal injury (OR 1.65; 95% CI 1.16-2.36), >1 sprain (OR 1.56; 95% CI 1.14-2.14), and time > 16 days (OR 1.75; 95% CI 1.12-2.74) were independently associated with cartilage damage. ROC analysis showed good discrimination for time since injury (AUC 0.893; optimal cutoff > 16.4 days) and number of sprains (AUC 0.889; operationally >/= 2), whereas BMI provided modest discrimination (AUC 0.629). These findings support risk-stratified early imaging, timely stabilization with meniscal management, and load-reduction strategies to mitigate structural progression. CI - Copyright (c) 2025 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Jin, Tianming AU - Jin T AD - Luzhou People's Hospital, Osteoarthritis Surgery, Luzhou, Sichuan, China. FAU - Huang, Yan AU - Huang Y AD - Luzhou People's Hospital, Department of Neonatology, Luzhou, Sichuan, China. FAU - Zhang, Qifeng AU - Zhang Q AUID- ORCID: 0009-0002-0252-7044 AD - Department of Orthopaedics, the Traditional Chinese Medical Hospital of Tongzhou, Nantong, Jiangsu, China. LA - eng PT - Journal Article PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R SB - IM MH - Adolescent MH - Adult MH - Female MH - Humans MH - Male MH - Middle Aged MH - Young Adult MH - *Anterior Cruciate Ligament Injuries/complications/surgery MH - Arthroscopy MH - Body Mass Index MH - *Cartilage, Articular/injuries/diagnostic imaging/pathology MH - Knee Joint/diagnostic imaging/pathology MH - Magnetic Resonance Imaging MH - Retrospective Studies MH - Risk Factors MH - ROC Curve MH - Tibial Meniscus Injuries/epidemiology PMC - PMC12727413 OTO - NOTNLM OT - anterior cruciate ligament OT - articular cartilage OT - meniscal injury OT - receiver operating characteristic OT - risk factors COIS- The authors have no funding and conflicts of interest to disclose. EDAT- 2025/12/23 07:47 MHDA- 2025/12/23 07:48 PMCR- 2025/12/19 CRDT- 2025/12/23 01:03 PHST- 2025/08/26 00:00 [received] PHST- 2025/10/23 00:00 [accepted] PHST- 2025/12/23 07:48 [medline] PHST- 2025/12/23 07:47 [pubmed] PHST- 2025/12/23 01:03 [entrez] PHST- 2025/12/19 00:00 [pmc-release] AID - 00005792-202512190-00069 [pii] AID - MD-D-25-11037 [pii] AID - 10.1097/MD.0000000000046103 [doi] PST - ppublish SO - Medicine (Baltimore). 2025 Dec 19;104(51):e46103. doi: 10.1097/MD.0000000000046103. PMID- 41430208 OWN - NLM STAT- MEDLINE DCOM- 20251230 LR - 20260101 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Dec 22 TI - Physical activity barriers, nutrition, motivation, and body composition in university students. PG - 4307 LID - 10.1186/s12889-025-26048-y [doi] LID - 4307 AB - BACKGROUND: Young adulthood is a period in which long-term lifestyle patterns are established. Barriers such as time constraints, low motivation, and environmental limitations may reduce participation in physical activity and hinder healthy nutritional behaviours. This study examined the relationships among nutritional attitudes, barriers to physical activity, general motivation, and body composition in university students. METHOD: A cross-sectional design was used with 600 students (M = 21.08 +/- 1.85(years); 50% women). Nutritional attitudes, physical activity barriers, and general motivation were assessed using validated scales, and body composition was measured using bioelectrical impedance analysis. Analyses included t-tests, correlations, and multiple regression. Regression models were structured to examine how nutritional attitudes and general motivation relate to perceived barriers, aligning the analytical approach with the theoretical framework. Regression assumptions and sampling procedures were checked prior to analysis. RESULTS: Students showed moderately positive nutritional attitudes (M = 40.53) and perceived personal factors as the most prominent barriers (M = 30.19). Men scored higher in nutritional attitudes, whereas women reported higher barrier perceptions and higher general motivation levels. Nutritional attitudes were negatively associated with barriers (r = -.332), and general motivation showed a weaker but significant negative association (r = -.189). Nutritional attitudes predicted 11% of the variance in barriers (R(2) = 0.110), increasing to 12.5% when general motivation was included. Positive nutritional attitudes were associated with higher muscle mass (beta = 0.270) and lower fat percentage (beta = -0.156), while barrier perceptions showed the opposite pattern. The negative association between barriers and all motivation subscales (including amotivation) indicates that higher barriers correspond to lower overall motivational engagement rather than increased amotivation. CONCLUSION: Integrating behavioural scales with body composition measures shows that nutritional attitudes, general motivation, and perceived barriers jointly shape students' healthy lifestyle profiles. These findings can inform gender-sensitive, university-based health promotion programs designed to reduce barriers and strengthen students' overall motivational regulation. CI - (c) 2025. The Author(s). FAU - Akil, Mustafa AU - Akil M AUID- ORCID: 0000-0003-1161-9231 AD - Faculty of Sport Sciences, University of Usak, Usak, Turkiye. mustafa.akil@usak.edu.tr. FAU - Tokay, Bekir AU - Tokay B AUID- ORCID: 0000-0003-0059-0736 AD - Faculty of Sport Sciences, University of Usak, Usak, Turkiye. FAU - Gungor, Melek Gulem AU - Gungor MG AUID- ORCID: 0000-0003-1928-6304 AD - Faculty of Sport Sciences, University of Usak, Usak, Turkiye. LA - eng PT - Journal Article DEP - 20251222 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Male MH - *Motivation MH - *Students/psychology/statistics & numerical data MH - Cross-Sectional Studies MH - Universities MH - *Body Composition MH - Young Adult MH - *Exercise/psychology MH - Adult MH - *Nutritional Status MH - Surveys and Questionnaires MH - Adolescent PMC - PMC12752208 OTO - NOTNLM OT - Barriers to physical activity OT - Body composition OT - Motivation OT - Nutritional attitudes OT - University students COIS- Declarations. Ethics approval and consent to participate: This study was conducted in accordance with the ethical standards of the Declaration of Helsinki. Ethical approval was obtained from the Ethics Committee of Usak University (E. E.287026; Decision No: 2025 - 193). All participants were informed about the research procedures and provided written informed consent prior to participation. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/23 00:27 MHDA- 2025/12/30 07:41 PMCR- 2025/12/22 CRDT- 2025/12/22 23:37 PHST- 2025/09/08 00:00 [received] PHST- 2025/12/17 00:00 [accepted] PHST- 2025/12/30 07:41 [medline] PHST- 2025/12/23 00:27 [pubmed] PHST- 2025/12/22 23:37 [entrez] PHST- 2025/12/22 00:00 [pmc-release] AID - 10.1186/s12889-025-26048-y [pii] AID - 26048 [pii] AID - 10.1186/s12889-025-26048-y [doi] PST - epublish SO - BMC Public Health. 2025 Dec 22;25(1):4307. doi: 10.1186/s12889-025-26048-y. PMID- 41429978 OWN - NLM STAT- MEDLINE DCOM- 20260308 LR - 20260813 IS - 1476-5497 (Electronic) IS - 0307-0565 (Print) IS - 0307-0565 (Linking) VI - 50 IP - 3 DP - 2026 Mar TI - Infant social withdrawal and rapid infant weight gain. PG - 671-678 LID - 10.1038/s41366-025-01996-y [doi] AB - BACKGROUND: Rapid infant weight gain (RIWG) and infant social withdrawal are important early markers of risk of subsequent overweight/obesity and mental health problems, respectively. While overweight and mental health problems are linked later in life, it remains unclear if this association is present already in infancy. OBJECTIVE: We examine if infant social withdrawal is associated with subsequent RIWG independently of an array of known risk factors (gestational age, birth weight, sex, parity, breastfeeding, maternal postpartum depressive symptoms, maternal smoking during pregnancy, maternal age at birth and pre-pregnancy BMI, family educational level, and employment status). METHODS: In a cohort of 12,468 children born 2015-19 in Copenhagen, we analyzed the association between infant social withdrawal around age 3 months, measured with the Alarm Distress Baby Scale (ADBB)-a validated screening tool, and subsequent RIWG. We retrieved information on social withdrawal and weight during infancy from health visitors' records and linked these to register data. Multivariate logistic regression was used to estimate adjusted odds ratios (aOR) and 95% confidence intervals (CI) for RIWG, adjusting for the known risk factors outlined above. RESULTS: Children showing signs of social withdrawal had 1.19 higher odds of RIWG compared to children showing no signs of social withdrawal (aOR 1.19; 95% CI: 1.03, 1.37, p = 0.017). RIWG was also more likely among boys, firstborns, children born small-for-gestational age, and those with mothers who smoked during pregnancy or had higher pre-pregnancy BMI. In contrast, higher birth weight and breastfeeding >4 months were protective factors. No associations were found with maternal postpartum depression, low education, parental labor market status, or maternal age. CONCLUSIONS: We found an association between infant social withdrawal and subsequent rapid infant weight gain independently of an array of known risk factors, which may expand our understanding of the developmental origins of excess weight gain and its association with early childhood mental health. CI - (c) 2025. The Author(s). FAU - Sander, Sarah AU - Sander S AUID- ORCID: 0000-0002-1917-0304 AD - Centre of Excellence in Early Intervention and Family Studies, Department of Psychology, University of Copenhagen, Copenhagen, Denmark. FAU - Stuart, Anne Christine AU - Stuart AC AUID- ORCID: 0000-0003-3829-9995 AD - Centre of Excellence in Early Intervention and Family Studies, Department of Psychology, University of Copenhagen, Copenhagen, Denmark. ach@psy.ku.dk. FAU - Stougaard, Maria AU - Stougaard M AD - Steno Diabetes Center Copenhagen, Herlev, Denmark. FAU - Sorensen, Thorkild I A AU - Sorensen TIA AUID- ORCID: 0000-0003-4821-430X AD - Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. AD - NNF Centre for Basic Metabolic Health, University of Copenhagen, Copenhagen, Denmark. FAU - Mohr, Julie Elisabeth Warberg AU - Mohr JEW AUID- ORCID: 0000-0002-0545-4584 AD - Centre of Excellence in Early Intervention and Family Studies, Department of Psychology, University of Copenhagen, Copenhagen, Denmark. FAU - Vaever, Mette Skovgaard AU - Vaever MS AD - Centre of Excellence in Early Intervention and Family Studies, Department of Psychology, University of Copenhagen, Copenhagen, Denmark. AD - National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251222 PL - England TA - Int J Obes (Lond) JT - International journal of obesity (2005) JID - 101256108 SB - IM MH - Humans MH - Female MH - *Weight Gain/physiology MH - Infant MH - Male MH - Risk Factors MH - Denmark/epidemiology MH - Pregnancy MH - Adult MH - Infant, Newborn MH - Pediatric Obesity/epidemiology MH - Cohort Studies MH - *Social Isolation/psychology MH - Body Mass Index PMC - PMC12965871 COIS- Competing interests: SS, ACS, JEWM and MSV are employed at the Centre of Excellence in Early Intervention and Family Studies where training in the use of the ADBB scale is offered as part of the continuing education program at the University of Copenhagen. Ethics approval and consent to participate: Under Danish law, research projects based solely on existing register data do not require individual informed consent. The DAIC project, of which the current study is a subproject, was approved by the ethics committee at the Department of Psychology, University of Copenhagen (ref number: IP-EC-08042025-1). EDAT- 2025/12/23 00:27 MHDA- 2026/03/08 01:38 PMCR- 2025/12/22 CRDT- 2025/12/22 23:25 PHST- 2025/04/09 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2025/10/29 00:00 [revised] PHST- 2026/03/08 01:38 [medline] PHST- 2025/12/23 00:27 [pubmed] PHST- 2025/12/22 23:25 [entrez] PHST- 2025/12/22 00:00 [pmc-release] AID - 10.1038/s41366-025-01996-y [pii] AID - 1996 [pii] AID - 10.1038/s41366-025-01996-y [doi] PST - ppublish SO - Int J Obes (Lond). 2026 Mar;50(3):671-678. doi: 10.1038/s41366-025-01996-y. Epub 2025 Dec 22. PMID- 41429376 OWN - NLM STAT- MEDLINE DCOM- 20260309 LR - 20260309 IS - 1879-0518 (Electronic) IS - 0010-7824 (Linking) VI - 156 DP - 2026 Apr TI - Evaluating variation between states in algorithms used for identifying abortions in Medicaid claims data. PG - 111328 LID - S0010-7824(25)00519-0 [pii] LID - 10.1016/j.contraception.2025.111328 [doi] AB - OBJECTIVES: To evaluate the variability in abortion identification across four published algorithms using Medicaid claims data in states where abortion is covered by Medicaid for all indications. STUDY DESIGN: We analyzed 2020 Medicaid Transformed Medicaid Statistical Information System Analytic Files from 14 states with Medicaid abortion coverage. Female recipients aged 15 to 44 were included. Four previously published algorithms, each using different combinations of diagnosis, procedure (Current Procedural Terminology/Healthcare Common Procedure Coding System), and medication (National Drug Classification) codes, were applied to identify abortion-related claims. For each algorithm, we calculated the number of identified abortions by state and examined variability in identification patterns and code types. RESULTS: Among 9.67 million Medicaid enrollees, the number of identified abortions varied substantially by algorithm and state. The max-to-min ratio across algorithms was lowest in Hawaii (2.09) and highest in New Jersey (138.59). Algorithms differed in their use of diagnosis-only, procedure-only, or both code types, with the proportion of claims containing both codes ranging from 0.4% (New Jersey) to 86.2% (Vermont). Abortions identified solely by Healthcare Common Procedure Coding System codes for mifepristone or misoprostol varied from 0.1% to 32.6% by state. No algorithm consistently performed well across all states. CONCLUSIONS: Substantial heterogeneity exists in the performance of abortion-identifying algorithms across states. These differences likely reflect variation in billing practices, Medicaid data reporting, and algorithm construction. IMPLICATIONS: Researchers should exercise caution when using claims data to estimate abortion rates, particularly across multiple states. Validation of an algorithm using health record data is needed. CI - Copyright (c) 2026 Elsevier Inc. All rights reserved. FAU - Rodriguez, Maria I AU - Rodriguez MI AD - Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, United States; Center for Health Systems Effectiveness, Oregon Health & Science University, Portland, OR, United States. Electronic address: rodrigma@ohsu.edu. FAU - Daly, Ashley AU - Daly A AD - Center for Health Systems Effectiveness, Oregon Health & Science University, Portland, OR, United States. FAU - Watson, Kelsey AU - Watson K AD - Center for Health Systems Effectiveness, Oregon Health & Science University, Portland, OR, United States. FAU - Kim, Hyunjee AU - Kim H AD - Center for Health Systems Effectiveness, Oregon Health & Science University, Portland, OR, United States. FAU - Swartz, Jonas J AU - Swartz JJ AD - Department of Obstetrics & Gynecology, Duke University, Durham, NC, United States. FAU - Meath, Thomas AU - Meath T AD - Center for Health Systems Effectiveness, Oregon Health & Science University, Portland, OR, United States. LA - eng PT - Journal Article DEP - 20251220 PL - United States TA - Contraception JT - Contraception JID - 0234361 SB - IM MH - United States MH - Humans MH - *Medicaid/statistics & numerical data MH - Female MH - *Algorithms MH - *Abortion, Induced/statistics & numerical data MH - Pregnancy MH - Adult MH - Adolescent MH - Young Adult MH - Insurance Claim Review OTO - NOTNLM OT - Abortion OT - Algorithm OT - Claims data OT - Health services EDAT- 2025/12/23 00:27 MHDA- 2026/03/09 07:41 CRDT- 2025/12/22 19:33 PHST- 2025/07/25 00:00 [received] PHST- 2025/12/13 00:00 [revised] PHST- 2025/12/15 00:00 [accepted] PHST- 2026/03/09 07:41 [medline] PHST- 2025/12/23 00:27 [pubmed] PHST- 2025/12/22 19:33 [entrez] AID - S0010-7824(25)00519-0 [pii] AID - 10.1016/j.contraception.2025.111328 [doi] PST - ppublish SO - Contraception. 2026 Apr;156:111328. doi: 10.1016/j.contraception.2025.111328. Epub 2025 Dec 20. PMID- 41428491 OWN - NLM STAT- MEDLINE DCOM- 20260424 LR - 20260424 IS - 1878-6324 (Electronic) IS - 1053-8127 (Linking) VI - 39 IP - 3 DP - 2026 May TI - Occupation-based intervention for subacromial pain syndrome: A pilot randomized controlled trial. PG - 1021-1031 LID - 10.1177/10538127251407664 [doi] AB - BackgroundSubacromial pain syndrome (SAPS) frequently causes functional limitations. Conventional therapies target impairments, whereas occupation-based approaches emphasize meaningful activity engagement to enhance functional recovery.ObjectiveThis pilot randomized controlled trial explored the feasibility and preliminary efficacy of an occupation-based intervention (OBI) for SAPS.MethodsThirty adults aged 18-65 years with chronic SAPS were randomly assigned to OBI (n = 15) or no-treatment control (NT, n = 15). OBI provided twelve sessions over four weeks, mixing preparatory exercises with meaningful tasks chosen via the Occupational Performance Measure (COPM). Outcomes were pain and disability (Shoulder Pain and Disability Index, SPADI), COPM performance and satisfaction, sleep, fatigue, and life satisfaction (SWLS). Nonparametric analyses were used with Wilcoxon signed-rank and Mann-Whitney U tests; effect sizes were rank-biserial r and Cliff's Delta.ResultsOBI produced large within-group reductions in SPADI pain (r = 0.88) and disability (r = 0.87), marked improvements in COPM performance and satisfaction (r approximately 1.0), and better sleep (r = 0.79; between-group Delta = -0.56, p = 0.009). Fatigue decreased substantially within OBI (r = - 0.94) but the between-group contrast was small and not significant. The NT group showed no statistically significant change on any outcome; SWLS remained stable in both arms.ConclusionA four-week occupation-based program is feasible and yields clinically meaningful improvements in pain, disability, sleep, and occupation-centred outcomes in people with SAPS. These preliminary findings support larger trials comparing OBI with standard rehabilitation to confirm efficacy and long-term benefits. FAU - Sigirtmac, Ilkem Ceren AU - Sigirtmac IC AUID- ORCID: 0000-0002-2740-8618 AD - Faculty of Health Sciences, Occupational Therapy Department, Cankiri Karatekin University, Cankiri, Turkey. FAU - Ay Kiremitci, Nermin AU - Ay Kiremitci N AD - Faculty of Health Sciences, Occupational Therapy Department, Hacettepe University, Ankara, Turkey. FAU - Bulbul, Ozgur AU - Bulbul O AD - Orthopaedic Surgery, Private Practice at Sogutozu Mah, Ankara, Turkey. FAU - Ekici, Gamze AU - Ekici G AD - Faculty of Health Sciences, Occupational Therapy Department, Hacettepe University, Ankara, Turkey. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20251222 PL - United States TA - J Back Musculoskelet Rehabil JT - Journal of back and musculoskeletal rehabilitation JID - 9201340 SB - IM MH - Humans MH - Pilot Projects MH - Male MH - Female MH - Adult MH - Middle Aged MH - *Occupational Therapy/methods MH - *Shoulder Impingement Syndrome/rehabilitation MH - Disability Evaluation MH - Aged MH - *Shoulder Pain/rehabilitation MH - Young Adult MH - Treatment Outcome MH - Adolescent OTO - NOTNLM OT - occupational performance OT - pain OT - shoulder OT - upper limb COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/12/22 19:42 MHDA- 2026/04/24 06:33 CRDT- 2025/12/22 12:43 PHST- 2026/04/24 06:33 [medline] PHST- 2025/12/22 19:42 [pubmed] PHST- 2025/12/22 12:43 [entrez] AID - 10.1177/10538127251407664 [doi] PST - ppublish SO - J Back Musculoskelet Rehabil. 2026 May;39(3):1021-1031. doi: 10.1177/10538127251407664. Epub 2025 Dec 22. PMID- 41428420 OWN - NLM STAT- MEDLINE DCOM- 20260801 LR - 20260805 IS - 1708-8283 (Electronic) IS - 0883-0738 (Linking) VI - 41 IP - 8 DP - 2026 Sep TI - Sleep and Fatigue in Children and Adolescents With Multiple Sclerosis. PG - 1132-1140 LID - 10.1177/08830738251396170 [doi] AB - Fatigue is common in children with multiple sclerosis. This cross-sectional study aimed to determine the prevalence of fatigue, sleep disorders, and subjective sleep quality in children with multiple sclerosis, along with their relationships to mood, quality of life, physical activity, and multiple sclerosis disease characteristics. Validated questionnaires were completed, and objective sleep quality was evaluated with polysomnography. Of the 18 children recruited (median age 16.0 years), 72% reported fatigue and 61% experienced subjective sleep disturbance. Fourteen sleep studies were completed, from which 3 children (21%) were diagnosed with sleep disorders: 2 with periodic limb movement disorder and 1 with mild obstructive sleep apnea. Sleep architecture was fragmented in 13 children (93%). Fatigue correlated with subjective sleep disturbance measures. This study demonstrates an increased frequency of subjective and objective sleep disturbance in children with multiple sclerosis. Polysomnography should be considered in children with multiple sclerosis who report fatigue and subjective sleep disturbance. FAU - Tran, Jessica AU - Tran J AD - Department of Paediatrics, University of Melbourne, Parkville, Australia. AD - Neuroscience Research Group, Murdoch Children's Research Institute, Parkville, Australia. AD - Department of Neurology, Royal Children's Hospital, Melbourne, Parkville, Australia. AD - Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Melbourne, Parkville, Australia. FAU - Adams, Anne-Marie AU - Adams AM AD - Department of Paediatrics, University of Melbourne, Parkville, Australia. AD - Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Melbourne, Parkville, Australia. AD - Respiratory Research Group, Murdoch Children's Research Institute, Parkville, Australia. FAU - Said, Jackie L AU - Said JL AD - Neuroscience Research Group, Murdoch Children's Research Institute, Parkville, Australia. AD - Department of Neurology, Royal Children's Hospital, Melbourne, Parkville, Australia. FAU - Kornberg, Andrew J AU - Kornberg AJ AD - Department of Paediatrics, University of Melbourne, Parkville, Australia. AD - Neuroscience Research Group, Murdoch Children's Research Institute, Parkville, Australia. AD - Department of Neurology, Royal Children's Hospital, Melbourne, Parkville, Australia. FAU - Vandeleur, Moya AU - Vandeleur M AD - Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Melbourne, Parkville, Australia. AD - Respiratory Research Group, Murdoch Children's Research Institute, Parkville, Australia. FAU - Yiu, Eppie M AU - Yiu EM AUID- ORCID: 0000-0001-6704-8402 AD - Department of Paediatrics, University of Melbourne, Parkville, Australia. AD - Neuroscience Research Group, Murdoch Children's Research Institute, Parkville, Australia. AD - Department of Neurology, Royal Children's Hospital, Melbourne, Parkville, Australia. LA - eng PT - Journal Article DEP - 20251222 PL - United States TA - J Child Neurol JT - Journal of child neurology JID - 8606714 SB - IM MH - Humans MH - *Fatigue/epidemiology/etiology MH - *Multiple Sclerosis/complications/epidemiology MH - Female MH - Male MH - Child MH - *Sleep Wake Disorders/epidemiology/etiology MH - Adolescent MH - Cross-Sectional Studies MH - Polysomnography MH - Surveys and Questionnaires MH - Quality of Life MH - Prevalence OTO - NOTNLM OT - adolescents OT - children OT - fatigue OT - multiple sclerosis OT - sleep COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/12/22 19:42 MHDA- 2026/08/01 06:35 CRDT- 2025/12/22 12:13 PHST- 2026/08/01 06:35 [medline] PHST- 2025/12/22 19:42 [pubmed] PHST- 2025/12/22 12:13 [entrez] AID - 10.1177/08830738251396170 [doi] PST - ppublish SO - J Child Neurol. 2026 Sep;41(8):1132-1140. doi: 10.1177/08830738251396170. Epub 2025 Dec 22. PMID- 41428312 OWN - NLM STAT- Publisher LR - 20260813 IS - 1543-0154 (Electronic) IS - 0885-8195 (Print) IS - 0885-8195 (Linking) DP - 2025 Dec 22 TI - Integrating Cancer Prevention into Science Education: Development of the CARES4You School-based Curriculum. LID - 10.1007/s13187-025-02812-x [doi] AB - Adolescents and young adults (ages 15-39) represent the only U.S. age group with rising cancer incidence, underscoring the need for early prevention. Yet, awareness of cancer risk factors among adolescents remains low, and few evidence-based programs are integrated into school curricula. The Cancer Risk Education in Schools for Youth and Families (CARES4You) study aims to co-design a middle school cancer prevention curriculum with teachers to ensure feasibility, alignment with science standards, and relevance to students' lived experiences. Using a mixed-methods approach, data were collected through three complementary sources: (1) Focus groups with 39 teachers and administrators from five New York City public middle schools explored curriculum content, classroom fit, and caregiver engagement. Sessions were recorded, transcribed, and analyzed thematically; (2) Classroom observations (n = 6) documented instructional context, student engagement, teaching strategies, and resource availability, with field notes analyzed descriptively; and (3) Content field testing with Math for America (MfA) fellows (n = 33) piloted two curriculum units on nicotine and dietary-related cancer risk. Teachers completed structured surveys and provided open-ended feedback on feasibility, clarity, and engagement. Data across all sources were triangulated to identify convergent themes related to feasibility, implementation, and contextual adaptation. Teachers viewed the curriculum as relevant, flexible, and culturally resonant. Six themes emerged: teacher receptivity, environmental context, lessons beyond the curriculum, integration strategies, effective practices, and caregiver engagement. Respondents valued hands-on learning and real-world connections but cited limited time and resources. Integrating teacher co-design with cancer prevention represents a promising, sustainable strategy to enhance adolescent cancer literacy and intergenerational health awareness. CI - (c) 2025. The Author(s) under exclusive licence to American Association for Cancer Education. FAU - Komsany, Alia AU - Komsany A AD - Division of General Internal Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, USA. FAU - McCooty, Kiana AU - McCooty K AD - Weill Medical College of Cornell University, New York, NY, USA. FAU - Fox, Jared AU - Fox J AD - Fox Edu Consulting, Washington, D.C, USA. FAU - Shah, Uzma AU - Shah U AD - Math for America, New York, NY, USA. FAU - Leak, Tashara M AU - Leak TM AD - Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA. FAU - McDonald, Jasmine A AU - McDonald JA AD - Herbert Irving Comprehensive Cancer Center and the Department of Epidemiology, Columbia University Irving Medical Center, New York, NY, USA. FAU - Terry, Mary Beth AU - Terry MB AD - Herbert Irving Comprehensive Cancer Center and the Department of Epidemiology, Columbia University Irving Medical Center, New York, NY, USA. AD - Silent Spring Institute, Newton, MA, USA. FAU - Soroka, Orysya AU - Soroka O AD - Division of General Internal Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, USA. FAU - Phillips, Erica AU - Phillips E AUID- ORCID: 0000-0002-6803-2442 AD - Division of General Internal Medicine, Department of Medicine, Weill Cornell Medicine, New York, NY, USA. erp2001@med.cornell.edu. AD - Cancer Prevention and Control Program, Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA. erp2001@med.cornell.edu. LA - eng GR - U54 CA280808/CA/NCI NIH HHS/United States GR - U54CA280808/Division of Cancer Prevention, National Cancer Institute/ PT - Journal Article DEP - 20251222 PL - England TA - J Cancer Educ JT - Journal of cancer education : the official journal of the American Association for Cancer Education JID - 8610343 SB - IM PMC - PMC12949675 MID - NIHMS2135032 OTO - NOTNLM OT - Adolescent and young adult cancers OT - Cancer education OT - Cancer-focused curriculum OT - STEM education OT - Social determinants COIS- Declarations. Ethics Approval: All procedures were approved by the Biomedical Research Alliance of New York (BRANY) [protocol # 22-12025527] and the NYC Department of Education Institutional Review Boards [protocol # 4928]. Conflict of interests: The authors declare no competing interests. EDAT- 2025/12/22 12:55 MHDA- 2025/12/22 12:55 PMCR- 2026/02/28 CRDT- 2025/12/22 11:35 PHST- 2025/10/31 00:00 [received] PHST- 2025/12/12 00:00 [accepted] PHST- 2025/12/22 12:55 [medline] PHST- 2025/12/22 12:55 [pubmed] PHST- 2025/12/22 11:35 [entrez] PHST- 2026/02/28 00:00 [pmc-release] AID - 10.1007/s13187-025-02812-x [pii] AID - 10.1007/s13187-025-02812-x [doi] PST - aheadofprint SO - J Cancer Educ. 2025 Dec 22:10.1007/s13187-025-02812-x. doi: 10.1007/s13187-025-02812-x. PMID- 41428130 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20261010 IS - 1863-2491 (Electronic) IS - 1863-2483 (Linking) VI - 20 IP - 1 DP - 2025 Dec 22 TI - Feasibility of aesthetic port placement in robot-assisted pyeloplasty a single institute study in all age groups. PG - 109 LID - 10.1007/s11701-025-03046-1 [doi] AB - This study aimed to identify patient factors associated with aesthetic port placement in robot-assisted pyeloplasty (RAPP) at a single institute treating all age groups. Patients who underwent multiport da Vinci RAPP between 2015 and 2023 were retrospectively reviewed. Port placement was determined based on the location of the ureteropelvic junction. The non-visible port position was defined as that placed in the umbilicus or below the bikini line. Demographic data were compared between the aesthetic (zero or only one visible port scar) and non-aesthetic (two or more visible port scars) port placement groups. Receiver operating characteristic (ROC) curve analysis and multivariable logistic regression were performed to assess the determinants of aesthetic placement. Forty-five patients were included (18 males and 27 females; age: 2-69, median 23 years). Sixteen of the 17 patients (94%) aged 15 years achieved aesthetic port placement. Compared with the non-aesthetic port placement group, the aesthetic port placement group was significantly younger, shorter, and had a lower body mass index (all p < 0.05). Independent determinant for aesthetic port placement was body mass index (OR = 0.40, 95% CI: 0.18-0.66, p = 0.004) and age (OR = 0.93, 95% CI: 0.86-0.98, p = 0.025). ROC analysis identified body mass index as the strongest predictor (area under the curve = 0.931, cutoff = 20.6). These findings provide a basis for preoperative port planning and instructions for patients who are concerned for wound cosmesis. FAU - Shimatani, Kimihiro AU - Shimatani K AD - Department of Urology, Hyogo College of Medicine, Hyogo Medical University, 1-1 Mukogawacho, Nishinomiya, Japan. AD - Department of Urology, Meiwa Hospital, Agenaruo-cho 4-31, Nishinomiya, Japan. FAU - Kanematsu, Akihiro AU - Kanematsu A AD - Department of Urology, Hyogo College of Medicine, Hyogo Medical University, 1-1 Mukogawacho, Nishinomiya, Japan. aqui@hyo-med.ac.jp. FAU - Oshima, Koichi AU - Oshima K AD - Department of Urology, Hyogo College of Medicine, Hyogo Medical University, 1-1 Mukogawacho, Nishinomiya, Japan. FAU - Yanagi, Toeki AU - Yanagi T AD - Department of Urology, Hyogo College of Medicine, Hyogo Medical University, 1-1 Mukogawacho, Nishinomiya, Japan. FAU - Saito, Ryoichi AU - Saito R AD - Department of Urology, Hyogo College of Medicine, Hyogo Medical University, 1-1 Mukogawacho, Nishinomiya, Japan. FAU - Yamamoto, Shingo AU - Yamamoto S AD - Department of Urology, Hyogo College of Medicine, Hyogo Medical University, 1-1 Mukogawacho, Nishinomiya, Japan. LA - eng PT - Journal Article DEP - 20251222 PL - England TA - J Robot Surg JT - Journal of robotic surgery JID - 101300401 SB - IM MH - Humans MH - Female MH - *Robotic Surgical Procedures/methods MH - Adolescent MH - Retrospective Studies MH - Adult MH - Male MH - Child, Preschool MH - Child MH - Middle Aged MH - Feasibility Studies MH - Aged MH - Young Adult MH - *Kidney Pelvis/surgery MH - Esthetics MH - Age Factors MH - *Urologic Surgical Procedures/methods OTO - NOTNLM OT - All age groups OT - Patient factor OT - Port scar OT - Robot assisted pyeloplasty COIS- Declarations. Conflicts of interest: The authors declare no competing interests. EDAT- 2025/12/22 12:56 MHDA- 2026/06/27 06:44 CRDT- 2025/12/22 11:16 PHST- 2025/11/14 00:00 [received] PHST- 2025/12/06 00:00 [accepted] PHST- 2026/06/27 06:44 [medline] PHST- 2025/12/22 12:56 [pubmed] PHST- 2025/12/22 11:16 [entrez] AID - 10.1007/s11701-025-03046-1 [pii] AID - 10.1007/s11701-025-03046-1 [doi] PST - epublish SO - J Robot Surg. 2025 Dec 22;20(1):109. doi: 10.1007/s11701-025-03046-1. PMID- 41427911 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20260919 IS - 1878-2620 (Electronic) IS - 1499-4046 (Print) IS - 1499-4046 (Linking) VI - 58 IP - 3 DP - 2026 Mar TI - A Qualitative Study of Nutrition Behaviors and Community Resources for Autistic Adolescents and Young Adults. PG - 167-179 LID - S1499-4046(25)00500-7 [pii] LID - 10.1016/j.jneb.2025.11.013 [doi] AB - OBJECTIVE: We evaluated influences on nutrition behaviors and barriers and facilitators to accessing nutrition resources for autistic adolescents and young adults (AYAs) aged 15-25 years. DESIGN: Zoom semistructured interviews (30-60 minutes) using a modified community-based participatory research approach. SETTING: Urban, suburban, and rural areas in New Mexico. PARTICIPANTS: Seven autistic AYAs aged 18-25 years (43% male), 7 caregivers, and 7 service providers. PHENOMENON OF INTEREST: Influences on nutrition behaviors and access to nutrition resources, guided by the social ecological model. ANALYSIS: Thematic analysis, validated through iterative coding and review by researchers and a community advisory board. RESULTS: Themes common across groups included lack of tailored nutrition programs addressing social and sensory needs, difficulties navigating traditional food environments, and financial constraints limiting access to nutrient-dense foods. Participants emphasized the value of flexible, adaptive formats-especially online and group-based-and the importance of routine, sensory considerations, and familiar foods. Caregivers and providers highlighted external influences of the school food environment and peers, and a lack of awareness of available resources. CONCLUSIONS AND IMPLICATIONS: Findings highlight the need for structured, sensory-inclusive nutrition programs that integrate community-based and digital resources, emphasize self-efficacy, and address environmental and social influences to promote long-term healthy eating habits for autistic AYAs. CI - Copyright (c) 2025 Society for Nutrition Education and Behavior. Published by Elsevier Inc. All rights reserved. FAU - Buro, Acadia W AU - Buro AW AD - College of Population Health, University of New Mexico Health Sciences Center, Albuquerque, NM. Electronic address: aburo@salud.unm.edu. FAU - Asencio Pimentel, Monica F AU - Asencio Pimentel MF AD - Cradle to Career Policy Institute, University of New Mexico, Albuquerque, NM. FAU - Brakey, Heidi Rishel AU - Brakey HR AD - Clinical and Translational Science Center, University of New Mexico Health Sciences Center, Albuquerque, NM. FAU - Sowrin, Mussammat Snigdha AU - Sowrin MS AD - College of Population Health, University of New Mexico Health Sciences Center, Albuquerque, NM. FAU - Sussman, Andrew L AU - Sussman AL AD - Department of Family and Community Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM. FAU - Gonzales-Pacheco, Diana M AU - Gonzales-Pacheco DM AD - College of Education & Human Sciences, University of New Mexico, Albuquerque, NM. FAU - Gregg, Shannon AU - Gregg S AD - Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM. FAU - Bomke, Lindsey M AU - Bomke LM AD - University of New Mexico Sandoval Regional Medical Center, Albuquerque, NM. FAU - Osbourn, Patricia L AU - Osbourn PL AD - Center for Development and Disability, A University Center for Excellence in Developmental Disabilities, University of New Mexico Health Sciences Center, Albuquerque, NM. FAU - Belone, Lorenda AU - Belone L AD - College of Population Health, University of New Mexico Health Sciences Center, Albuquerque, NM. FAU - Jimenez, Elizabeth Yakes AU - Jimenez EY AD - College of Population Health, University of New Mexico Health Sciences Center, Albuquerque, NM; Cradle to Career Policy Institute, University of New Mexico, Albuquerque, NM; Department of Pediatrics, University of New Mexico Health Sciences Center, Albuquerque, NM; Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, NM. LA - eng GR - UL1 TR001449/TR/NCATS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20251222 PL - United States TA - J Nutr Educ Behav JT - Journal of nutrition education and behavior JID - 101132622 SB - IM MH - Humans MH - Adolescent MH - Male MH - Young Adult MH - Female MH - Adult MH - Qualitative Research MH - *Autistic Disorder/psychology MH - *Feeding Behavior/psychology MH - New Mexico MH - Community-Based Participatory Research PMC - PMC12724635 MID - NIHMS2126077 OTO - NOTNLM OT - adolescents and young adults OT - autism OT - autistic OT - interviews OT - nutrition COIS- CONFLICT OF INTEREST DISCLOSURE The authors have not stated any conflicts of interest. EDAT- 2025/12/22 12:55 MHDA- 2026/03/07 06:38 PMCR- 2026/05/22 CRDT- 2025/12/22 10:28 PHST- 2025/05/15 00:00 [received] PHST- 2025/11/19 00:00 [revised] PHST- 2025/11/25 00:00 [accepted] PHST- 2026/03/07 06:38 [medline] PHST- 2025/12/22 12:55 [pubmed] PHST- 2025/12/22 10:28 [entrez] PHST- 2026/05/22 00:00 [pmc-release] AID - S1499-4046(25)00500-7 [pii] AID - 10.1016/j.jneb.2025.11.013 [doi] PST - ppublish SO - J Nutr Educ Behav. 2026 Mar;58(3):167-179. doi: 10.1016/j.jneb.2025.11.013. Epub 2025 Dec 22. PMID- 41427097 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251222 LR - 20251224 IS - 1735-4587 (Print) IS - 2008-2215 (Electronic) IS - 1735-4587 (Linking) VI - 20 IP - 4 DP - 2025 Oct TI - Designing and Compiling a Special Parenting Package to Use Digital Technology in Iranian Children and Adolescents. PG - 441-451 LID - 10.18502/ijps.v20i4.19681 [doi] AB - Objective: This study aimed to design and validate a culturally tailored educational package for Iranian parents of children and adolescents aged 0 to 18. The package addresses the safe and effective use of a range of digital technologies, including social media, online games, and educational applications. It focuses on enhancing parents' knowledge, monitoring capabilities, and strategies to mitigate digital risks, with consideration of Iranian cultural values and family dynamics. Method : The content was developed through a review of literature across multiple English and Persian databases, including PubMed, Scopus, Web of Science, Iran Medex, Magiran, and SID. Relevant keywords and MeSH terms related to parenting, digital technology, and cultural adaptation were used. Cultural appropriateness was ensured through consultations with a panel of experts in psychiatry, child development, and digital education, along with qualitative input from Iranian parents via focus groups and interviews. Results: The finalized educational package comprises 12 well-structured chapters covering topics such as digital literacy, online safety, parental supervision, balancing screen time, effective family communication, and related legal and ethical issues contextualized for Iranian society. The package achieved high content validity, with all chapters scoring above 0.79 on the Content Validity Index (CVI) and Content Validity Ratio (CVR). Conclusion: This culturally adapted package offers an evidence-based resource that empowers Iranian parents by increasing their awareness, sharpening their supervisory and communication skills, and supporting the healthy and responsible use of digital technologies among their children. Future steps include pilot testing and evaluating the package's effectiveness and scalability in real-world settings. CI - Copyright (c) 2025 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences. FAU - Alaghband Rad, Javad AU - Alaghband Rad J AD - Department of Psychiatry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. FAU - Karamooz, Anahita AU - Karamooz A AD - Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran. FAU - Sharifi, Vandad AU - Sharifi V AD - Department of Psychiatry, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. FAU - Raaii, Farzaneh AU - Raaii F AD - Department of Psychiatry, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran. LA - eng PT - Journal Article PL - Iran TA - Iran J Psychiatry JT - Iranian journal of psychiatry JID - 101302041 PMC - PMC12712400 OTO - NOTNLM OT - Children and Adolescent OT - Cultural Characteristics OT - Digital Technology OT - Education OT - Parents COIS- None. EDAT- 2025/12/22 12:56 MHDA- 2025/12/22 12:57 PMCR- 2025/10/01 CRDT- 2025/12/22 07:00 PHST- 2025/05/16 00:00 [received] PHST- 2025/07/22 00:00 [revised] PHST- 2025/07/30 00:00 [accepted] PHST- 2025/12/22 12:57 [medline] PHST- 2025/12/22 12:56 [pubmed] PHST- 2025/12/22 07:00 [entrez] PHST- 2025/10/01 00:00 [pmc-release] AID - IJPS-20-441 [pii] AID - 10.18502/ijps.v20i4.19681 [doi] PST - ppublish SO - Iran J Psychiatry. 2025 Oct;20(4):441-451. doi: 10.18502/ijps.v20i4.19681. PMID- 41426692 OWN - NLM STAT- MEDLINE DCOM- 20251222 LR - 20251224 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Expanding the theory of planned behavior to predict fruits and vegetables consumption among a sample of women in Saudi Arabia. PG - 1720598 LID - 10.3389/fpubh.2025.1720598 [doi] LID - 1720598 AB - BACKGROUND: Adequate fruit and vegetable (F&V) intake is a key component of a healthy diet and is influenced by both psychological and environmental factors. AIM: to explore determinants of F&V consumption among Saudi adult women, applying an extended Theory of Planned Behavior (TPB) model. METHODS: A cross-sectional survey recruited 476 Saudi adult women aged 18-59 across all five regions of Saudi Arabia. Data were collected using a validated online questionnaire assessing TPB constructs, socio-demographics, lifestyle behaviors, and dietary patterns. Structural equation modeling (SEM) was used to test both the original and extended TPB models. RESULTS: Participants held positive attitudes but demonstrated low adherence, consuming a mean of 3.33 F&V servings daily. In the original TPB model, intention, and perceived behavioral control (PBC) significantly predicted behavior (R(2) = 31%), while attitude, subjective norms, and PBC predicted intention (R(2) = 75%). The extended model explained 45% of the variance in behavior, with PBC as the sole direct significant predictor. Knowledge and family meal frequency positively influenced attitudes, while F&V purchasing, and a healthy diet were associated with higher PBC. CONCLUSION: PBC emerged as the only direct predictor of behavior in the extended model. Moreover, this study highlighted the crucial role of PBC in translating intention into the actual consumption of fruits and vegetables among Saudi women. Family-centered strategies that strengthen women's confidence and skills in healthy meal planning may effectively bridge the intention-behavior gap. CI - Copyright (c) 2025 Abusalih, Alasmari, Abduljawad, Almaski, Almughamisi, Fatani, Tashkandi, Aljehani, Saaty and Benajiba. FAU - Abusalih, Howeida AU - Abusalih H AD - Department of Health Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi Arabia. FAU - Alasmari, Sarah A AU - Alasmari SA AD - College of Health Sciences, Public Health Department, Saudi Electronic University, Riyadh, Saudi Arabia. FAU - Abduljawad, Suha Hashim AU - Abduljawad SH AD - College of Applied Medical Sciences, Department of Clinical Nutrition, Taibah University, Medina, Saudi Arabia. FAU - Almaski, Ameerah AU - Almaski A AD - College of Applied Medical Sciences, Department of Clinical Nutrition, Taibah University, Medina, Saudi Arabia. FAU - Almughamisi, Manal AU - Almughamisi M AD - College of Applied Medical Sciences, Department of Clinical Nutrition, Taibah University, Medina, Saudi Arabia. FAU - Fatani, Asmaa AU - Fatani A AD - Food and Nutrition Department, Human Sciences and Design Faculty, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Tashkandi, Bayan AU - Tashkandi B AD - Food and Nutrition Department, Human Sciences and Design Faculty, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Aljehani, Abeer A AU - Aljehani AA AD - Food and Nutrition Department, Human Sciences and Design Faculty, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Saaty, Afnan H AU - Saaty AH AD - Food and Nutrition Department, Human Sciences and Design Faculty, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Benajiba, Nada AU - Benajiba N AD - Ibn Tofail University-CNESTEN, Joint Research Unit in Nutrition and Food, RDC-Nutrition AFRA/IAEA, Rabat, Morocco. LA - eng PT - Journal Article DEP - 20251204 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Saudi Arabia MH - Female MH - *Fruit MH - Adult MH - *Vegetables MH - Cross-Sectional Studies MH - Middle Aged MH - Adolescent MH - Surveys and Questionnaires MH - Young Adult MH - *Feeding Behavior/psychology MH - Intention MH - Health Knowledge, Attitudes, Practice MH - *Health Behavior MH - *Transtheoretical Model MH - Diet/statistics & numerical data MH - Theory of Planned Behavior PMC - PMC12713309 OTO - NOTNLM OT - Saudi Arabia OT - adult women OT - attitude OT - fruits and vegetables consumption OT - intention OT - perceived behavioral control OT - social norms OT - theory of planned behavior COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer BA declared a shared affiliation with the authors AF, BT, AAA, and AS to the handling editor at the time of review. EDAT- 2025/12/22 18:09 MHDA- 2025/12/22 18:10 PMCR- 2025/12/04 CRDT- 2025/12/22 06:56 PHST- 2025/10/08 00:00 [received] PHST- 2025/11/09 00:00 [revised] PHST- 2025/11/14 00:00 [accepted] PHST- 2025/12/22 18:10 [medline] PHST- 2025/12/22 18:09 [pubmed] PHST- 2025/12/22 06:56 [entrez] PHST- 2025/12/04 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1720598 [doi] PST - epublish SO - Front Public Health. 2025 Dec 4;13:1720598. doi: 10.3389/fpubh.2025.1720598. eCollection 2025. PMID- 41426690 OWN - NLM STAT- MEDLINE DCOM- 20251222 LR - 20251224 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Ethnic and residential differences in adherence to the 24-h movement guidelines and self-reported physical fitness among Zhuang and Han adolescents in southern China. PG - 1631277 LID - 10.3389/fpubh.2025.1631277 [doi] LID - 1631277 AB - BACKGROUND: The 24-h movement guidelines integrate physical activity (PA), screen time, and sleep for health benefits, yet little is known about how adherence to these guidelines relates to physical fitness (PF) among adolescents, particularly in the context of ethnic and residential differences. This study examines the independent and combined associations of adhering to the 24-h movement guidelines with self-reported PF among Han and Zhuang adolescents in southern China, while exploring potential differences by residence and ethnicity. METHODS: Cross-sectional data from 6,913 adolescents were analyzed using a validated self-reported questionnaire to assess adherence to the 24-h movement guidelines and PF components (cardiorespiratory fitness, cardiorespiratory fitness, speed/agility, muscular strength, and flexibility). Generalized linear models were used to examine associations. RESULTS: In this sample, only 1.6% of participants met the overall guidelines. Meeting more guidelines was significantly (p < 0.001) associated with better self-reported PF indicators. The combinations containing moderate-to-vigorous physical activity (MVPA) guideline were significantly (p < 0.05) associated with self-reported PF indicators enhancement compared to those combinations without MVPA guideline. Meeting screen time guideline was significantly (p < 0.05) associated with more self-reported PF indicators, but not in the case of meeting sleep duration guideline. Most of the results were similar for Han and Zhuang ethnicity, whereas residence differences exerted a significant impact on the relationship between adherence to "Screen only," "Sleep only," and "Screen + sleep" guideline and self-reported PF indicators. CONCLUSION: Our findings highlight the critical role of adhering to the 24-h movement guidelines, mainly MVPA, in improving self-reported PF among adolescents and underscore the need to address urban-rural disparities in promoting the 24-h movement guidelines. CI - Copyright (c) 2025 Qian, Tan, Tang and Zou. FAU - Qian, Hongsheng AU - Qian H AD - School of Physical Education, Wuhan Sports University, Wuhan, China. FAU - Tan, Jingwang AU - Tan J AD - Department of Sport and Exercise Science, College of Education, Zhejiang University, Hangzhou, China. FAU - Tang, Jiaxing AU - Tang J AD - School of Physical Education, Xiangnan University, Chenzhou, China. FAU - Zou, Yu AU - Zou Y AD - Department of Sport and Exercise Science, College of Education, Zhejiang University, Hangzhou, China. LA - eng PT - Journal Article DEP - 20251204 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Zhuang people RN - Han Chinese people SB - IM MH - Adolescent MH - Female MH - Humans MH - Male MH - China MH - Cross-Sectional Studies MH - *Ethnicity/statistics & numerical data MH - *Exercise MH - *Guideline Adherence/statistics & numerical data MH - Guidelines as Topic MH - *Physical Fitness MH - *Residence Characteristics/statistics & numerical data MH - Screen Time MH - Self Report MH - Surveys and Questionnaires MH - East Asian People PMC - PMC12711711 OTO - NOTNLM OT - ethnicity OT - movement guidelines OT - physical activity OT - physical fitness OT - residence OT - screen time OT - sleep duration COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/22 18:09 MHDA- 2025/12/22 18:10 PMCR- 2025/12/04 CRDT- 2025/12/22 06:56 PHST- 2025/05/19 00:00 [received] PHST- 2025/11/16 00:00 [revised] PHST- 2025/11/24 00:00 [accepted] PHST- 2025/12/22 18:10 [medline] PHST- 2025/12/22 18:09 [pubmed] PHST- 2025/12/22 06:56 [entrez] PHST- 2025/12/04 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1631277 [doi] PST - epublish SO - Front Public Health. 2025 Dec 4;13:1631277. doi: 10.3389/fpubh.2025.1631277. eCollection 2025. PMID- 41426267 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251222 LR - 20251224 IS - 2325-9671 (Print) IS - 2325-9671 (Electronic) IS - 2325-9671 (Linking) VI - 13 IP - 12 DP - 2025 Dec TI - Associated Factors of Primary Cam Morphology in 4477 Early Adolescents: A Multiethnic, Population-Based, Cross-sectional Study (Generation R). PG - 23259671251394027 LID - 10.1177/23259671251394027 [doi] LID - 23259671251394027 AB - BACKGROUND: Multiple prospective cohort studies have consistently shown a strong association between cam morphology and the development of hip osteoarthritis. However, associated factors of primary cam morphology (PCM) in the general adolescent population remain largely unexplored. PURPOSE: To investigate associated factors of the presence of PCM and increased alpha angle in early adolescents from the general population. STUDY DESIGN: Cross-sectional study; Level of evidence, 3. METHODS: The authors included 4477 participants with high-resolution dual-energy x-ray absorptiometry scans of the right hip from the population-based Generation R cohort in Rotterdam, the Netherlands. The alpha angle was automatically measured using validated methods. PCM was defined as an alpha angle >/=60 degrees . The authors used multivariable logistic and linear regression models to investigate factors (demographic, anthropometric, and lifestyle factors and proximal femoral physis status) associated with PCM and increased alpha angle, respectively. RESULTS: Of the included participants (median age, 13.5 years [2.5th-97.5th percentile, 13.2-14.6]; 51.6% female, 73.7% European), 151 (3.4%) had PCM. Male sex (adjusted odds ratio [aOR], 2.56; 95% CI, 1.62-4.04) and closed proximal femoral physis (aOR 3.28; 95% CI, 2.05-5.24) were associated with higher odds of PCM, whereas underweight (aOR 0.42; 95% CI, 0.18-0.97) was associated with lower odds of PCM. Factors associated with increased alpha angle included male sex (beta coefficient, 2.99; 95% CI, 2.40-3.58), closed proximal femoral physis (beta coefficient, 1.22; 95% CI, 0.61-1.82), cutting sport type (beta coefficient, 1.07; 95% CI, 0.30-1.85), overweight (beta coefficient, 0.89; 95% CI, 0.22-1.55), and obesity (beta coefficient, 1.81; 95% CI, 0.57-3.04). Ethnicity and physical activity frequency were not associated with PCM or increased alpha angle. CONCLUSION: Among Dutch early adolescents, male sex and proximal femoral physis closure were associated factors of PCM and increased alpha angle, while cutting sport type, overweight, and obesity were modifiable factors of increased alpha angle. These findings could inform potential primary prevention strategies for PCM. CI - (c) The Author(s) 2025. FAU - Chen, Delong AU - Chen D AUID- ORCID: 0009-0004-6570-5172 AD - Department of Orthopaedics and Sports Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. AD - The Generation R Study Group, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. FAU - Boel, Fleur AU - Boel F AUID- ORCID: 0000-0002-0421-9478 AD - Department of Orthopaedics and Sports Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. AD - The Generation R Study Group, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. FAU - van Klij, Pim AU - van Klij P AD - Amsterdam UMC location University of Amsterdam, Department of Orthopedic Surgery and Sports Medicine, Academic Center for Evidence Based Medicine, Amsterdam IOC Center ACHSS, Amsterdam, the Netherlands. AD - Amsterdam Movement Sciences, Sports, Amsterdam, the Netherlands. AD - Department of Sports Medicine, Isala Hospital, Zwolle, the Netherlands. FAU - Runhaar, Jos AU - Runhaar J AD - Department of General Practice, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. FAU - Rivadeneira, Fernando AU - Rivadeneira F AD - The Generation R Study Group, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. AD - Department of Internal Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. FAU - Bierma-Zeinstra, Sita M A AU - Bierma-Zeinstra SMA AD - Department of Orthopaedics and Sports Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. AD - The Generation R Study Group, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. AD - Department of General Practice, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. FAU - Agricola, Rintje AU - Agricola R AUID- ORCID: 0000-0002-0645-093X AD - Department of Orthopaedics and Sports Medicine, Erasmus MC University Medical Center Rotterdam, Rotterdam, the Netherlands. LA - eng PT - Journal Article DEP - 20251219 PL - United States TA - Orthop J Sports Med JT - Orthopaedic journal of sports medicine JID - 101620522 PMC - PMC12717396 OTO - NOTNLM OT - associated factors OT - early adolescents OT - general population OT - hip osteoarthritis OT - primary cam morphology COIS- One or more of the authors has declared the following potential conflict of interest or source of funding: D.C. has received a grant from the China Scholarship Council (202108430032). J.R. has received a grant from the Dutch Arthritis Society. S.M.A.B.-Z. has received a grant from EU ERC HIPSTAR paid to the institution and the Dutch Arthritis Society. R.A. has received a grant from the Dutch Arthritis Society. AOSSM checks author disclosures against the Open Payments Database (OPD). AOSSM has not conducted an independent investigation on the OPD and disclaims any liability or responsibility relating thereto. EDAT- 2025/12/22 12:55 MHDA- 2025/12/22 12:56 PMCR- 2025/12/19 CRDT- 2025/12/22 06:52 PHST- 2025/08/22 00:00 [received] PHST- 2025/09/12 00:00 [accepted] PHST- 2025/12/22 12:56 [medline] PHST- 2025/12/22 12:55 [pubmed] PHST- 2025/12/22 06:52 [entrez] PHST- 2025/12/19 00:00 [pmc-release] AID - 10.1177_23259671251394027 [pii] AID - 10.1177/23259671251394027 [doi] PST - epublish SO - Orthop J Sports Med. 2025 Dec 19;13(12):23259671251394027. doi: 10.1177/23259671251394027. eCollection 2025 Dec. PMID- 41425778 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251222 LR - 20251224 IS - 2589-790X (Electronic) IS - 2589-790X (Linking) VI - 7 IP - 11 DP - 2025 Nov TI - Reducing Socioeconomic Inequalities in Adult Cardiovascular Disease Risk by Targeting Unhealthy Movement Behaviours During Adolescence: A Protocol. PG - 1495-1506 LID - 10.1016/j.cjco.2025.08.002 [doi] AB - Populations with lower socioeconomic position (SEP) are at increased risk of developing cardiovascular disease (CVD). Movement behaviours, including physical activity, sedentary behaviour, and sleep, contribute to socioeconomic gradients in CVD risk, as low-SEP populations are less likely to meet evidence-informed recommendations for these behaviours. Adolescence represents a sensitive period for establishing lifelong health behaviours, with CVD risk beginning to accumulate before adulthood. This study will model the potential effect of adolescent movement behaviour interventions on socioeconomic inequalities in adult CVD risk. We will conduct a population-based cohort study of adolescents from the Add Health study, recruited in 1994-1995 from the US and followed into adulthood. Unhealthy movement behaviours, including a low level of moderate-to-vigorous physical activity, a high level of recreational screen time, and short sleep duration, will be operationalized based on the 24-hour Movement Guidelines and measured twice during adolescence (ages 12-24 years). Parental educational attainment and family financial hardship will be used to capture SEP in adolescence. The outcome will be the 30-year risk of CVD, assessed in adulthood (ages 33-41 years) using a validated risk score that incorporates objectively measured biomarkers, demographic information, and self-reported health indicators. We will perform causal decompositions to quantify the change of socioeconomic inequalities in adult CVD risk under 2 interventional scenarios: (i) elimination (unhealthy movement behaviours are eliminated in the whole population of adolescents); and (ii) equalization (the distributions of unhealthy movement behaviours for low-SEP adolescents are equalized to those of high-SEP adolescents). This study will provide insights into how modifying adolescent movement behaviours may contribute to reducing socioeconomic inequalities in CVD risk. CI - (c) 2025 The Authors. FAU - Grubic, Nicholas AU - Grubic N AD - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. FAU - Maximova, Katerina AU - Maximova K AD - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. AD - MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Toronto, Ontario, Canada. FAU - Chiolero, Arnaud AU - Chiolero A AD - Department of Epidemiology, Biostatistics and Occupational Health, School of Population and Global Health, McGill University, Montreal, Quebec, Canada. AD - Population Health Laboratory (#PopHealthLab), University of Fribourg, Fribourg, Switzerland. AD - Swiss School of Public Health (SSPH+), Zurich, Switzerland. FAU - Siddiqi, Arjumand AU - Siddiqi A AD - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. AD - Edwin S.H. Leong Centre for Healthy Children, Hospital for Sick Children, Toronto, Ontario, Canada. AD - Department of Social and Behavioural Sciences, Harvard School of Public Health, Boston, Massachusetts, USA. AD - Department of Health Behaviour, Gillings School of Global Public Health, University of North Carolina-Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Carsley, Sarah AU - Carsley S AD - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. AD - Health Promotion, Chronic Disease and Injury Prevention, Public Health Ontario, Toronto, Ontario, Canada. FAU - Batomen, Brice AU - Batomen B AD - Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada. FAU - Harris, Kathleen Mullan AU - Harris KM AD - Department of Sociology and Carolina Population Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. FAU - Carmeli, Cristian AU - Carmeli C AD - Population Health Laboratory (#PopHealthLab), University of Fribourg, Fribourg, Switzerland. AD - Swiss School of Public Health (SSPH+), Zurich, Switzerland. LA - eng PT - Journal Article DEP - 20250813 PL - United States TA - CJC Open JT - CJC open JID - 101763635 PMC - PMC12713191 OTO - NOTNLM OT - adolescence OT - cardiovascular disease OT - causal decomposition OT - inequalities OT - movement behaviours EDAT- 2025/12/22 18:09 MHDA- 2025/12/22 18:10 PMCR- 2025/08/13 CRDT- 2025/12/22 06:47 PHST- 2025/06/10 00:00 [received] PHST- 2025/08/07 00:00 [accepted] PHST- 2025/12/22 18:10 [medline] PHST- 2025/12/22 18:09 [pubmed] PHST- 2025/12/22 06:47 [entrez] PHST- 2025/08/13 00:00 [pmc-release] AID - S2589-790X(25)00521-9 [pii] AID - 10.1016/j.cjco.2025.08.002 [doi] PST - epublish SO - CJC Open. 2025 Aug 13;7(11):1495-1506. doi: 10.1016/j.cjco.2025.08.002. eCollection 2025 Nov. PMID- 41424726 OWN - NLM STAT- MEDLINE DCOM- 20251222 LR - 20261016 IS - 2167-8359 (Electronic) IS - 2167-8359 (Linking) VI - 13 DP - 2025 TI - Cross-cultural adaptation and validation of a Resistance Training Skill Battery for use in Chinese-speaking adolescents. PG - e20387 LID - 10.7717/peerj.20387 [doi] LID - e20387 AB - PURPOSE: Although the Resistance Training Skills Battery (RTSB) is a well-established instrument for assessing resistance training (RT) skill competency in Western populations, its applicability to Chinese adolescents remains unvalidated. This study aimed to translate, cross-culturally adapted, and validated the RTSB for Mandarin-speaking Chinese adolescents. METHODS: Employing established guidelines for cross-cultural adaptation, our study involved translating the RTSB into Chinese (RTSB-C), followed by back-translation, adaptation, and validation. The study quantified test-retest reliability, intra- and inter-rater reliability, and construct validity. Adolescents aged 12-16 years (n = 64) underwent two RTSB-C assessments, two weeks apart. Muscular fitness was evaluated using muscle fitness tests (handgrip strength, timed push-up, and countermovement jumps) to establish criterion validity. RESULTS: The RTSB-C demonstrated fair to excellent test-retest reliability across the two timepoints, the intra-class coefficient (ICC) for the RTSB-C was notably high at 0.94 (95% CI [0.90-0.95]); The intra-rater reliability was 0.94 (p < 0.001), and inter-rater reliability was 0.41-0.93 (p < 0.05). Construct validity was confirmed through linear regression analysis, with the model accounting for 46.8% of the variance in muscle fitness scores (MFS), and with gender (r = 0.47, p < 0.001) and RTSB-C scores (r = 0.45, p < 0.001) emerging as significant predictors. CONCLUSIONS: We successfully translated and cross-culturally adapted the RTSB from English to Chinese, affirming its reliability and validity in assessing the RT skills of Chinese-speaking adolescents. The RTSB-C is recommended for accurate evaluation of RT competence in this demographic. CI - (c)2025 Zha et al. FAU - Zha, Xiaolu AU - Zha X AD - School of Physical Education, Shanghai University of Sport, Shanghai, China. FAU - Lubans, David AU - Lubans D AD - Faculty of Sport and Health Sciences, University of Jyvaskyla, Jyvaskyla, Finland. AD - Centre for Active Living and Learning, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Smith, Jordan AU - Smith J AD - Centre for Active Living and Learning, University of Newcastle, Callaghan, New South Wales, Australia. FAU - Wang, Ran AU - Wang R AD - School of Athletic Performance, Shanghai University of Sport, Shanghai, China. LA - eng GR - Shanghai Key Lab of Human Performance (Shanghai University of sport)/ PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Validation Study DEP - 20251215 PL - United States TA - PeerJ JT - PeerJ JID - 101603425 RN - Chinese people SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Reproducibility of Results MH - Child MH - *Resistance Training MH - China MH - *Cross-Cultural Comparison MH - Translations MH - East Asian People PMC - PMC12713556 OTO - NOTNLM OT - Motor skill OT - Muscular fitness OT - Physical fitness OT - Strength training OT - Youth training COIS- The authors declare there are no competing interests. EDAT- 2025/12/22 18:09 MHDA- 2025/12/22 18:10 PMCR- 2025/12/15 CRDT- 2025/12/22 06:37 PHST- 2025/05/07 00:00 [received] PHST- 2025/10/22 00:00 [accepted] PHST- 2025/12/22 18:10 [medline] PHST- 2025/12/22 18:09 [pubmed] PHST- 2025/12/22 06:37 [entrez] PHST- 2025/12/15 00:00 [pmc-release] AID - 20387 [pii] AID - 10.7717/peerj.20387 [doi] PST - epublish SO - PeerJ. 2025 Dec 15;13:e20387. doi: 10.7717/peerj.20387. eCollection 2025. PMID- 41424415 OWN - NLM STAT- MEDLINE DCOM- 20260514 LR - 20260813 IS - 1879-3479 (Electronic) IS - 0020-7292 (Print) IS - 0020-7292 (Linking) VI - 173 IP - 3 DP - 2026 Jun TI - Machine learning-based prediction of large-for-gestational-age neonates in diabetic and non-diabetic pregnancies. PG - 1462-1471 LID - 10.1002/ijgo.70751 [doi] AB - OBJECTIVE: This study determines whether a machine-learning model integrating sonographic biometry with maternal clinical parameters improves prediction of large-for-gestational-age (LGA) compared with Hadlock's EFW formula. METHODS: We conducted a retrospective cohort study including all singleton live births at >/=32 gestational weeks at a tertiary medical center. Predictors comprised biparietal diameter, abdominal circumference, femur length, maternal demographics and anthropometrics, obstetric history, chronic and gestational morbidity, and glucose values from screening and diagnosis. A CatBoost gradient-boosting model estimated the probability of LGA (birthweight >/=90th percentile). Performance was compared with Hadlock's EFW using area under the curve (AUC) and detection at a fixed 10% false-positive rate. A prespecified subgroup analysis evaluated pregnancies with pregestational or gestational diabetes. Performance was assessed with fivefold cross-validation; calibration and utility were examined by decision curve analysis. RESULTS: Among 31 531 parturients, 18.17% delivered an LGA neonate. The model achieved an AUC of 0.946 (95% confidence interval [CI], 0.938-0.955), significantly outperforming Hadlock's EFW (AUC 0.867; 95% CI, 0.854-0.881; P = 0.01) and yielding a higher detection rate at a 10% false-positive rate (79% vs. 63%). The most influential contributors were abdominal circumference, gestational age at delivery, fetal sex, and maternal age. In 3871 diabetic pregnancies, among whom 24% delivered LGA, performance remained high (AUC 0.890; 95% CI, 0.847-0.918) and exceeded Hadlock's formula (AUC 0.820; 95% CI, 0.772-0.863; P = 0.02). CONCLUSION: A predictive algorithm, incorporating sonographic and non-sonographic features, as developed here, achieved superior accuracy compared to the traditional EFW formula in predicting LGA neonates, in both general and diabetic pregnant populations. CI - (c) 2025 The Author(s). International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics. FAU - Houri, Ohad AU - Houri O AUID- ORCID: 0000-0002-3393-813X AD - Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, Israel. AD - Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel. AD - BCNatal-Barcelona Center for Maternal-Fetal and Neonatal Medicine (Hospital Clinic and Hospital Sant Joan de Deu), University of Barcelona, Barcelona, Spain. FAU - Romano, Asaf AU - Romano A AD - Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, Israel. AD - Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Walfisch, Asnat AU - Walfisch A AD - Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, Israel. AD - Dina Recanati School of Medicine, Reichman University, Herzliya, Israel. FAU - Hadar, Eran AU - Hadar E AD - Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, Israel. AD - Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Gilboa, Yinon AU - Gilboa Y AD - Helen Schneider Hospital for Women, Rabin Medical Center, Petach Tikva, Israel. AD - Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel. FAU - Perl, Leor AU - Perl L AD - Faculty of Health and Medical Sciences, Tel Aviv University, Tel Aviv, Israel. AD - Department of Cardiology, Rabin Medical Center, Petach Tikva, Israel. FAU - Loebl, Nadav AU - Loebl N AD - Innovation Lab, Rabin Medical Center, Petach Tikva, Israel. FAU - Unger, Ron AU - Unger R AD - The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat Gan, Israel. LA - eng PT - Journal Article DEP - 20251222 PL - United States TA - Int J Gynaecol Obstet JT - International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics JID - 0210174 SB - IM MH - Humans MH - Pregnancy MH - Female MH - *Machine Learning MH - Retrospective Studies MH - *Diabetes, Gestational MH - Infant, Newborn MH - Adult MH - *Fetal Macrosomia/diagnosis MH - *Ultrasonography, Prenatal/methods MH - Gestational Age MH - Birth Weight MH - Predictive Value of Tests MH - Biometry/methods MH - Male PMC - PMC13173610 OTO - NOTNLM OT - diabetes OT - large-for-gestational-age machine learning OT - prediction COIS- The authors have no conflicts of interest to report. EDAT- 2025/12/22 12:55 MHDA- 2026/05/14 14:50 PMCR- 2026/05/14 CRDT- 2025/12/22 06:23 PHST- 2025/11/19 00:00 [revised] PHST- 2025/10/06 00:00 [received] PHST- 2025/11/29 00:00 [accepted] PHST- 2026/05/14 14:50 [medline] PHST- 2025/12/22 12:55 [pubmed] PHST- 2025/12/22 06:23 [entrez] PHST- 2026/05/14 00:00 [pmc-release] AID - IJGO70751 [pii] AID - 10.1002/ijgo.70751 [doi] PST - ppublish SO - Int J Gynaecol Obstet. 2026 Jun;173(3):1462-1471. doi: 10.1002/ijgo.70751. Epub 2025 Dec 22. PMID- 41424179 OWN - NLM STAT- MEDLINE DCOM- 20260209 LR - 20260211 IS - 1471-0528 (Electronic) IS - 1470-0328 (Print) IS - 1470-0328 (Linking) VI - 133 IP - 4 DP - 2026 Mar TI - Qualitative Assessment of Foetal Lung Size in Left Congenital Diaphragmatic Hernia Using Ultrasound and MRI: A Retrospective Cohort Study. PG - 833-841 LID - 10.1111/1471-0528.70120 [doi] AB - OBJECTIVE: To evaluate the reliability of qualitative foetal lung size assessments on ultrasound (US) and MRI in left congenital diaphragmatic hernia (CDH) and their correlation with quantitative metrics and neonatal mortality. DESIGN: Retrospective cohort study. SETTING: Single tertiary center, 2008-2020. POPULATION: A total of 103 cases of prenatally diagnosed isolated left CDH underwent postnatal active care. METHODS: Two independent reviewers performed qualitative foetal lung size assessments on US and MRI. Interrater agreement was assessed, and correlations were determined between qualitative assessments, quantitative metrics (observed-to-expected lung-to-head ratio [o/e LHR] and observed-to-expected total Foetal lung volume [o/e TFLV]), and neonatal mortality. MAIN OUTCOME MEASURES: Interrater agreement and correlation between qualitative and quantitative assessments of lung size and neonatal mortality. RESULTS: A total of 74 cases with both US and MRI imaging were included. Interrater agreement for qualitative lung size assessment was strong for US (weighted kappa: 0.80, 95% CI 0.68-0.93) and moderate for MRI (Cohen's kappa: 0.48, 95% CI 0.30-0.66). Both modalities showed a strong correlation between qualitative and quantitative lung size assessments. On US, qualitative and quantitative assessments had similar associations with neonatal mortality (Spearman's correlation: 0.44 for each reviewer vs. 0.49). On MRI, quantitative metrics correlated more strongly with neonatal mortality than qualitative assessment (Cramer's V: 0.44 vs. 0.34-0.35). CONCLUSIONS: Qualitative foetal lung size assessment, by US more so than MRI, is a reliable and reproducible tool that correlates with established quantitative metrics and neonatal mortality. These findings support its role as a complementary method for prenatal risk stratification in left CDH. CI - (c) 2025 The Author(s). BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd. FAU - Shinar, Shiri AU - Shinar S AUID- ORCID: 0000-0001-6352-4846 AD - Ontario Fetal Centre, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada. FAU - Kajal, Dilkash AU - Kajal D AD - Joint Department of Medical Imaging, Women's College Hospital and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada. FAU - Johnson, Sarah AU - Johnson S AD - Joint Department of Medical Imaging, Women's College Hospital and Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada. FAU - Otvodenko, Anna AU - Otvodenko A AD - Ontario Fetal Centre, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada. FAU - Lee, Seungwoo AU - Lee S AUID- ORCID: 0009-0002-7449-5985 AD - Maternal-Infant Care Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada. FAU - Chiu, Priscilla P L AU - Chiu PPL AD - Division of General and Thoracic Surgery, the Hospital for Sick Children, Department of Surgery, University of Toronto, Toronto, Ontario, Canada. FAU - Keunen, Johannes AU - Keunen J AD - Ontario Fetal Centre, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada. FAU - Van Mieghem, Tim AU - Van Mieghem T AD - Ontario Fetal Centre, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada. FAU - Ryan, Greg AU - Ryan G AD - Ontario Fetal Centre, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada. FAU - Shah, Prakesh S AU - Shah PS AD - Maternal-Infant Care Research Centre, Mount Sinai Hospital, Toronto, Ontario, Canada. AD - Department of Paediatrics, Division of Neonatology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada. FAU - Abbasi, Nimrah AU - Abbasi N AD - Ontario Fetal Centre, Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynaecology, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada. LA - eng PT - Journal Article DEP - 20251222 PL - England TA - BJOG JT - BJOG : an international journal of obstetrics and gynaecology JID - 100935741 SB - IM MH - Humans MH - *Hernias, Diaphragmatic, Congenital/diagnostic imaging/mortality/embryology MH - Retrospective Studies MH - Female MH - Pregnancy MH - *Lung/diagnostic imaging/embryology/pathology MH - *Ultrasonography, Prenatal/methods MH - *Magnetic Resonance Imaging/methods MH - Infant, Newborn MH - Reproducibility of Results MH - Organ Size MH - Adult MH - Infant Mortality PMC - PMC12884223 OTO - NOTNLM OT - CDH OT - MRI OT - congenital diaphragmatic hernia OT - correlation OT - foetal lungs OT - neonatal mortality OT - pulmonary hypoplasia OT - qualitative OT - ultrasound COIS- The authors declare no conflicts of interest. EDAT- 2025/12/22 06:29 MHDA- 2026/02/09 06:29 PMCR- 2026/02/09 CRDT- 2025/12/22 04:12 PHST- 2025/12/02 00:00 [revised] PHST- 2025/03/22 00:00 [received] PHST- 2025/12/04 00:00 [accepted] PHST- 2026/02/09 06:29 [medline] PHST- 2025/12/22 06:29 [pubmed] PHST- 2025/12/22 04:12 [entrez] PHST- 2026/02/09 00:00 [pmc-release] AID - BJO70120 [pii] AID - 10.1111/1471-0528.70120 [doi] PST - ppublish SO - BJOG. 2026 Mar;133(4):833-841. doi: 10.1111/1471-0528.70120. Epub 2025 Dec 22. PMID- 41424044 OWN - NLM STAT- MEDLINE DCOM- 20260318 LR - 20260318 IS - 2204-2091 (Electronic) IS - 2204-2091 (Linking) VI - 36 IP - 1 DP - 2026 Mar 26 TI - Prevalent, prominent and powerful: alcohol and unhealthy food and drink advertising at a major Melbourne public transport hub. LID - PU25080 [pii] LID - 10.1071/PU25080 [doi] AB - OBJECTIVES: Exposure to unhealthy food and alcohol advertising in childhood and adolescence can influence preferences and later consumption. A fragmented and ineffective network of regulations and guidelines covers outdoor advertising of alcohol to children in Victoria, and regulations for unhealthy food/non-alcoholic drinks are even less comprehensive. The aim of this study was to quantify the prevalence, size, and youth appeal of unhealthy food and drink (including alcohol) marketing at a major public transit hub in Melbourne: Southern Cross Station. This location is not subject to the Department of Transport and Planning rules regarding placement of unhealthy product marketing that apply to other public transport in Victoria. METHODS: A manual audit of all advertisements located inside Southern Cross station (including on internal walls, hanging from the ceiling, freestanding on concourse, walkways and platforms) took place over 4 days in June and July 2024. From photographs, researchers categorised all advertisements as either alcohol, food/non-alcoholic drink (and then as either unhealthy [discretionary] or healthy [core, based on Australian Dietary Guidelines]), or other; and coded the size of the advertisement. Food/drink (including alcohol) advertisements were coded for the presence of features with youth appeal using a validated measure. A total advertising power score for youth appeal was calculated. Mann-Whitney U-tests examined differences in size and youth appeal between categories. RESULTS: A total of 858 advertisements were identified: n = 213 (24.8%) were for food/non-alcoholic drinks (most of which were unhealthy, 83.1%), and n = 202 (23.5%) were for alcohol. Alcohol advertisements were significantly larger than both non-alcoholic drink and food/non-alcoholic drink advertisements combined (each P < 0.0001), and had a significantly higher number of features with youth appeal and a higher youth appeal score than both non-alcoholic drinks and food/non-alcoholic drinks combined (all P < 0.05). Youth appeal was also significantly higher for unhealthy than healthy food/non-alcoholic drink advertisements (P = 0.039). CONCLUSIONS: Advertisements for unhealthy food and drink, including alcohol, at Southern Cross station are prevalent, prominent and powerful in their potential appeal to youth. A coherent and comprehensive approach to regulating the content of advertising on public transport and in outdoor spaces is needed to protect children and adolescents. CI - (c) 2026 The Author(s) (or their employer(s)). Published by CSIRO Publishing on behalf of the Sax Institute. FAU - Haynes, Ashleigh AU - Haynes A AD - Centre for Behavioural Research in Cancer, Cancer Council Victoria, Level 8, Victoria Parade, East Melbourne, Vic, Australia. AD - Melbourne School of Psychological Sciences, The University of Melbourne, Parkville, Vic, Australia. FAU - McAleese, Alison AU - McAleese A AD - Prevention Division, Cancer Council Victoria, East Melbourne, Vic, Australia. AD - Present address: Alison McAleese Consulting, Melbourne, Vic, Australia. FAU - Ball, Ashlee AU - Ball A AD - Centre for Behavioural Research in Cancer, Cancer Council Victoria, Level 8, Victoria Parade, East Melbourne, Vic, Australia. FAU - Martin, Jane AU - Martin J AD - Food for Health Alliance, East Melbourne, Vic, Australia. LA - eng PT - Journal Article PL - Australia TA - Public Health Res Pract JT - Public health research & practice JID - 101648133 SB - IM MH - Humans MH - *Advertising/statistics & numerical data MH - Victoria MH - *Alcoholic Beverages MH - Adolescent MH - *Food MH - Child MH - *Alcohol Drinking MH - Male OTO - NOTNLM OT - adolescents OT - advertising OT - alcohol OT - children OT - marketing OT - public transport OT - sugary drinks OT - unhealthy food EDAT- 2025/12/22 06:29 MHDA- 2026/03/19 01:32 CRDT- 2025/12/22 02:32 PHST- 2025/08/13 00:00 [received] PHST- 2025/12/18 00:00 [accepted] PHST- 2026/03/19 01:32 [medline] PHST- 2025/12/22 06:29 [pubmed] PHST- 2025/12/22 02:32 [entrez] AID - 267799 [pii] AID - 10.1071/PU25080 [doi] PST - ppublish SO - Public Health Res Pract. 2026 Mar 26;36(1):PU25080. doi: 10.1071/PU25080. PMID- 41423628 OWN - NLM STAT- MEDLINE DCOM- 20260114 LR - 20260117 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2025 Dec 21 TI - Dynamic prediction of adolescent sports injury probability based on the improved ARIMA model in the background of digital physical education teaching. PG - 1903 LID - 10.1038/s41598-025-31591-0 [doi] LID - 1903 AB - This study aims to solve the problem of dynamic prediction of sports injuries in adolescent physical education teaching. By integrating multi-source heterogeneous data and improving time series modeling, a real-time early warning system suitable for digital education scenarios is constructed. In view of the limitations of traditional ARIMA models in capturing the suddenness and multi-frequency characteristics coordination of injury events, this study innovatively integrates Time-Varying Filtering Empirical Mode Decomposition (TVF-EMD) and Mixed-Frequency Data Sampling (MIDAS) techniques to achieve separate modeling of injury trend and fluctuation terms, and establish cross-scale correlation between second-level sports data and quarterly physical fitness assessment. In an empirical study involving 217 middle school student athletes, the model significantly improved prediction accuracy (multi-scenario average RMSE reduced by > 40%), with an accuracy rate of 86.2% in high-intensity basketball training, a false alarm rate of 5.2% for ACL injuries in football, and the critical threshold of fracture risk was determined when the monthly running distance exceeded 280 km in track and field training. According to the research, Key technical breakthroughs include dynamically optimizing model parameters through particle filtering to adapt to sudden changes in teaching load, using LightGBM residual correction mechanism to improve the ability to capture sudden injury events, and verifying the reliability of three-dimensional motion trajectory monitoring in virtual reality teaching (error < 12.3 mm). The research results provide core methodological support for constructing a real-time and personalized campus sports health protection system, and will be further validated through multi-center cohort studies to promote clinical translational applications. CI - (c) 2025. The Author(s). FAU - Wang, Kai AU - Wang K AD - School of Economics & Management, Wuhan Sports University, Wuhan, 430079, China. wangk01@yctu.edu.cn. AD - School of Physical Education, Yancheng Teachers University, Yancheng, 224002, China. wangk01@yctu.edu.cn. LA - eng PT - Journal Article DEP - 20251221 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Adolescent MH - *Athletic Injuries/epidemiology MH - *Physical Education and Training/methods MH - Male MH - Female MH - Probability MH - Athletes PMC - PMC12804994 OTO - NOTNLM OT - Digital physical education teaching OT - Dynamic parameter optimization OT - Improved ARIMA model OT - Multi-source data fusion OT - Sports injury prediction COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study was conducted in accordance with the guidelines of the Declaration of Helsinki and was approved by the Ethics Committee of Yancheng Teachers University. The studies were conducted in accordance with the local legislation and institutional requirements. Written informed consent for participation in this study was provided by the participants' legal guardians/next of kin. EDAT- 2025/12/22 00:28 MHDA- 2026/01/15 08:04 PMCR- 2025/12/21 CRDT- 2025/12/21 23:14 PHST- 2025/09/05 00:00 [received] PHST- 2025/12/03 00:00 [accepted] PHST- 2026/01/15 08:04 [medline] PHST- 2025/12/22 00:28 [pubmed] PHST- 2025/12/21 23:14 [entrez] PHST- 2025/12/21 00:00 [pmc-release] AID - 10.1038/s41598-025-31591-0 [pii] AID - 31591 [pii] AID - 10.1038/s41598-025-31591-0 [doi] PST - epublish SO - Sci Rep. 2025 Dec 21;16(1):1903. doi: 10.1038/s41598-025-31591-0. PMID- 41423608 OWN - NLM STAT- MEDLINE DCOM- 20260123 LR - 20260602 IS - 1471-244X (Electronic) IS - 1471-244X (Linking) VI - 26 IP - 1 DP - 2025 Dec 21 TI - A pilot study of the plasma and urinary neurotransmitters in Chinese children with autism spectrum disorder. PG - 59 LID - 10.1186/s12888-025-07682-7 [doi] LID - 59 AB - BACKGROUND: Recent studies have indicated that there are imbalances in neurotransmitter levels in children with autism spectrum disorder (ASD). Alterations in peripheral blood and urinary neurotransmitter levels may serve as biomarkers for ASD. METHODS: This study aims to explore the relationship between neurotransmitter levels and the severity of ASD. Totally, forty sex-, age-, and ethnically matched typically developing (TD) children were recruited to compare the neurotransmitter levels with ASD aged over 3 years. Differences in plasma and urinary neurotransmitter levels between TD children and children with ASD were compared using the Mann-Whitney U test. For the indicators that showed significant differences, further multivariate regression analysis was conducted to assess the association between individual neurotransmitters and Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) Calibrated Severity Score (CSS). Finally, a restricted cubic spline (RCS) model was applied to explore the dose-response relationship between neurotransmitter concentrations and ADOS-2 CSS. RESULTS: Plasma levels of dopamine (DA), normetanephrine (NMN), 5-hydroxytryptamine (5-HT), gamma-aminobutyric acid (gamma-GABA) levels in ASD were significantly higher than those in TD children while plasma levels of norepinephrine (NE), tyrosine (Tyr) were significantly lower. Urinary levels of NMN were significantly lower, while epinephrine (E), NE, vanillylmandelic acid (VMA), homovanillic acid (HVA) were significantly higher in children with ASD compared to TD. After adjusting for confounders of age, sex and BMI, plasma GABA was negatively associated with ADOS-2 CSS, while urinary NE and NMN were positively associated with ADOS severity scores (P ＜ 0.05). Multiple regression analysis indicated that plasma GABA and urinary NE and NMN levels explained 26.9%, 24.8% and 15.8% of the variability in ADOS-2 CSS for ASD. The RCS analysis results were largely consistent with the linear regression analysis results. Plasma GABA and urinary NE, and NMN exhibited a linear correlation with ADOS-2 CSS. Plasma NE and Tyr showed a U-shaped curve relationship with the ADOS-2 CSS (P< 0.05). CONCLUSIONS: A significant negative correlation was observed between plasma GABA neurotransmitter concentrations and ASD severity. In contrast, NE and NMN levels in urine showed significantly positive correlations with ASD severity. Both excessively low and excessively high plasma NE and Tyr levels may be associated with more severe autism symptoms, suggesting a disruption in peripheral neurotransmitter levels in children with ASD. Future studies with larger sample sizes are required for prediction and validation. The peripheral neurotransmitters may serve as potential auxiliary biomarkers for assessing the severity of autism. CI - (c) 2025. The Author(s). FAU - Xin, Yingying AU - Xin Y AUID- ORCID: 0000-0001-7116-9231 AD - Department of Child Health, Wuhan Children's Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, China. FAU - Yang, Yifan AU - Yang Y AD - Department of Child Health, Wuhan Children's Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, China. FAU - Qian, Qiaoqiao AU - Qian Q AD - Department of Neurology, Wuhan Children's Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, China. FAU - Xia, Ting AU - Xia T AD - Department of Child Health, Wuhan Children's Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, China. FAU - Zhang, Wanqing AU - Zhang W AD - Wuhan University of Science and Technology, Wuhan, 430016, China. FAU - Dai, Taoying AU - Dai T AD - Department of Child Health, Wuhan Children's Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, China. FAU - Li, Ruizhen AU - Li R AD - Department of Child Health, Wuhan Children's Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, China. FAU - Liu, Zhisheng AU - Liu Z AD - Department of Neurology, Wuhan Children's Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, China. liuzsc@126.com. FAU - Zhang, Chuanjie AU - Zhang C AD - Department of Child Health, Wuhan Children's Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430016, China. cjzhang45@126.com. LA - eng PT - Journal Article DEP - 20251221 PL - England TA - BMC Psychiatry JT - BMC psychiatry JID - 100968559 RN - 0 (Neurotransmitter Agents) RN - 0 (Biomarkers) RN - X4W3ENH1CV (Norepinephrine) RN - 333DO1RDJY (Serotonin) RN - VTD58H1Z2X (Dopamine) RN - 56-12-2 (gamma-Aminobutyric Acid) RN - Chinese people SB - IM MH - Humans MH - *Autism Spectrum Disorder/blood/urine MH - Male MH - Female MH - *Neurotransmitter Agents/blood/urine MH - Pilot Projects MH - Child, Preschool MH - Child MH - Biomarkers/blood/urine MH - China MH - Norepinephrine/blood/urine MH - Severity of Illness Index MH - Serotonin/blood/urine MH - Dopamine/blood/urine MH - gamma-Aminobutyric Acid/blood/urine MH - East Asian People PMC - PMC12829056 OTO - NOTNLM OT - Autism diagnostic observation schedule OT - Autism spectrum disorder OT - Calibrated severity score OT - Neurotransmitter COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Ethics Committee of Wuhan Children's Hospital, Huazhong University of Science and Technology (No:2024R017-E01). Informed consent was obtained from the guardians of the children involved in this study, which was in accordance with the Declaration of Helsinki and the Ethical Review Methods for Biomedical Research involving Humans adopted by the National Health and Family Planning Commission of the People's Republic of China. This research was registered in China National Medical Research Registration and Filing Information System, the Clinical Trial Number is MR-42-24-023506. Author agreement: All authors have read and agreed to the published version of the manuscript. The article is the our original work, hasn't received prior publication and isn't under consideration for publication elsewhere. Competing interests: The authors declare no competing interests. Consent for publication: Informed consent was obtained from the guardians of the children involved in this study for the publication of children's details. EDAT- 2025/12/22 00:28 MHDA- 2026/01/23 06:30 PMCR- 2025/12/21 CRDT- 2025/12/21 23:13 PHST- 2025/07/13 00:00 [received] PHST- 2025/12/01 00:00 [accepted] PHST- 2026/01/23 06:30 [medline] PHST- 2025/12/22 00:28 [pubmed] PHST- 2025/12/21 23:13 [entrez] PHST- 2025/12/21 00:00 [pmc-release] AID - 10.1186/s12888-025-07682-7 [pii] AID - 7682 [pii] AID - 10.1186/s12888-025-07682-7 [doi] PST - epublish SO - BMC Psychiatry. 2025 Dec 21;26(1):59. doi: 10.1186/s12888-025-07682-7. PMID- 41423366 OWN - NLM STAT- Publisher LR - 20251221 IS - 0929-6646 (Print) IS - 0929-6646 (Linking) DP - 2025 Dec 20 TI - Monitoring strategy and efficacy of GnRH analogue therapy in girls with central precocious puberty and early puberty. LID - S0929-6646(25)00689-8 [pii] LID - 10.1016/j.jfma.2025.12.032 [doi] AB - OBJECTIVES: This study evaluated the effectiveness of gonadotropin-releasing hormone analogue (GnRHa) therapy in girls with central precocious puberty (CPP) and early puberty (EP), aiming to identify a reliable marker for treatment monitoring and assessing long-term outcomes. STUDY DESIGN: A retrospective case study between 2001 and 2024, a total of 265 girls with rapidly progressive CPP or EP who received GnRHa therapy were enrolled. A GnRH stimulation test was performed after 12 weeks of therapy. Receiver operating characteristic curves and the Youden index were used to identify an optimal marker and define the cut-off value indicating effective suppression. Among them, 186 reached adult height, and their height outcomes were analyzed to identify predictive factors. RESULTS: After 12 weeks of GnRHa therapy, effective suppression was achieved in 94.3 % of patients. Unstimulated LH was a strong predictor (AUC = 0.85), with a cut-off of <0.4 IU/L (sensitivity, 65.5 %; specificity, 86.7 %). Growth outcomes showed that patients with CPP had better adult height than those with EP (156.5 vs. 153.9 cm, p < 0.001). Positive predictors included second-year growth velocity, predicted adult height at treatment initiation, and bone age standard deviation score, while a unstimulated LH level was negatively associated with final height. Long-term follow-up revealed that 34.9 % of patients had abnormal bone mineral density (31.5 % osteopenia and 3.4 % osteoporosis), although obesity rates were comparable to the general population. CONCLUSIONS: This study highlights the importance of early intervention and effective monitoring strategies, with unstimulated LH emerging as a useful marker for treatment efficacy. CI - Copyright (c) 2025 Formosan Medical Association. Published by Elsevier B.V. All rights reserved. FAU - Liu, Wen-Shin AU - Liu WS AD - Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Pediatrics, Jinshan branch, National Taiwan University Hospital, New Taipei City, Taiwan. FAU - Tsai, Wei-Yu AU - Tsai WY AD - Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan. FAU - Lee, Cheng-Ting AU - Lee CT AD - Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan. FAU - Liu, Shih-Yao AU - Liu SY AD - Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan. FAU - Tsai, Meng-Ju Melody AU - Tsai MM AD - Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan. FAU - Lin, Han-Yi AU - Lin HY AD - Department of Pediatrics, Hsinchu branch, National Taiwan University Hospital, Hsinchu, Taiwan. FAU - Tung, Yi-Ching AU - Tung YC AD - Department of Pediatrics, National Taiwan University Hospital and College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: dtped004@ntuh.gov.tw. LA - eng PT - Journal Article DEP - 20251220 PL - Singapore TA - J Formos Med Assoc JT - Journal of the Formosan Medical Association = Taiwan yi zhi JID - 9214933 SB - IM OTO - NOTNLM OT - Bone mineral density OT - Central precocious puberty OT - Early puberty OT - GnRH analogue OT - GnRH test EDAT- 2025/12/22 00:28 MHDA- 2025/12/22 00:28 CRDT- 2025/12/21 21:58 PHST- 2025/06/23 00:00 [received] PHST- 2025/12/04 00:00 [revised] PHST- 2025/12/15 00:00 [accepted] PHST- 2025/12/22 00:28 [medline] PHST- 2025/12/22 00:28 [pubmed] PHST- 2025/12/21 21:58 [entrez] AID - S0929-6646(25)00689-8 [pii] AID - 10.1016/j.jfma.2025.12.032 [doi] PST - aheadofprint SO - J Formos Med Assoc. 2025 Dec 20:S0929-6646(25)00689-8. doi: 10.1016/j.jfma.2025.12.032. PMID- 41422970 OWN - NLM STAT- MEDLINE DCOM- 20260119 LR - 20260119 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 398 DP - 2026 Apr 1 TI - Gastrointestinal symptoms mediate the association between dietary factors and sleep disturbances: A cross-sectional study on preschool children. PG - 120994 LID - S0165-0327(25)02436-X [pii] LID - 10.1016/j.jad.2025.120994 [doi] AB - BACKGROUND: Sleep disturbances in preschool children are associated with dietary patterns and eating behaviors. Gastrointestinal symptoms, which frequently result from poor dietary factors, may further impair sleep. This study examines the mediating effect of gastrointestinal symptoms in the association between dietary factors and sleep disturbances. METHODS: A cross-sectional online investigation recruited 7425 participants in Beijing, with 7170 included in the final analysis. Validated scales, including the Sleep Disturbance Scale for Children, Chinese Preschoolers' Eating Behavior Questionnaire, Preschool Nutrition Quotient Questionnaire, and Gastrointestinal Symptom Rating Scale, were used to assess dietary composition, eating behaviors, gastrointestinal symptoms, and sleep disturbances. RESULTS: Gastrointestinal symptoms exacerbate the damage to sleep caused by unhealthy dietary factors. Proportions mediated of gastrointestinal symptoms ranged from 17.98 % to 31.35 % on the total score of the Sleep Disturbance Scale for Children. A dietary pattern high in beverages and low in bean and fish products adversely affected sleep through gastrointestinal symptoms. The association between unhealthy eating behaviors and sleep disturbances has been validated, with proportion mediated of 61.89 % between sleep breathing disorders and low satiety responsiveness. LIMITATIONS: As a cross-sectional study, these results cannot rule out reverse causality-where sleep disturbances may influence eating behavior. or gastrointestinal symptoms. CONCLUSIONS: These findings emphasize the importance of correcting unhealthy dietary factors as key drivers of sleep disturbances. Interventions aimed at improving gastrointestinal health can simultaneously mitigate the harmful effects of unhealthy dietary factors, offering dual benefits for sleep in preschool children. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Jiang, Jiyu AU - Jiang J AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Chaoyang District, Beijing, 100029, PR China. FAU - Ma, Xueyan AU - Ma X AD - Institute of Chinese Medicine Epidemic Disease, Beijing University of Chinese Medicine, Yangguang South Street, Fangshan District, Beijing, 102488, PR China. FAU - Liu, Lina AU - Liu L AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Chaoyang District, Beijing, 100029, PR China. FAU - Li, Xue AU - Li X AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Chaoyang District, Beijing, 100029, PR China. FAU - Hou, Senlong AU - Hou S AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Chaoyang District, Beijing, 100029, PR China. FAU - Li, Shuxuan AU - Li S AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Chaoyang District, Beijing, 100029, PR China. FAU - Zhang, Hanwen AU - Zhang H AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Chaoyang District, Beijing, 100029, PR China. FAU - Ma, Qingpu AU - Ma Q AD - Qi-Huang Chinese Medicine School, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Beijing, 100029, PR China. FAU - Yu, He AU - Yu H AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Chaoyang District, Beijing, 100029, PR China. FAU - Liu, Tiegang AU - Liu T AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Chaoyang District, Beijing, 100029, PR China. Electronic address: liutg@bucm.edu.cn. FAU - Gu, Xiaohong AU - Gu X AD - School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, 11 North Third Ring Road East, Chaoyang District, Beijing, 100029, PR China. Electronic address: guxiaohong1962@163.com. LA - eng PT - Journal Article DEP - 20251219 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Male MH - Child, Preschool MH - Female MH - *Sleep Wake Disorders/epidemiology/etiology MH - *Feeding Behavior MH - *Gastrointestinal Diseases/complications/epidemiology MH - Surveys and Questionnaires MH - *Diet/adverse effects MH - China/epidemiology OTO - NOTNLM OT - Child OT - Dietary pattern OT - Eating behavior OT - Mediating effect OT - Sleep disturbance COIS- Declaration of competing interest The authors declare that they have no competing interests. EDAT- 2025/12/22 00:28 MHDA- 2026/01/20 00:37 CRDT- 2025/12/21 19:35 PHST- 2025/09/12 00:00 [received] PHST- 2025/12/12 00:00 [revised] PHST- 2025/12/18 00:00 [accepted] PHST- 2026/01/20 00:37 [medline] PHST- 2025/12/22 00:28 [pubmed] PHST- 2025/12/21 19:35 [entrez] AID - S0165-0327(25)02436-X [pii] AID - 10.1016/j.jad.2025.120994 [doi] PST - ppublish SO - J Affect Disord. 2026 Apr 1;398:120994. doi: 10.1016/j.jad.2025.120994. Epub 2025 Dec 19. PMID- 41421885 OWN - NLM STAT- MEDLINE DCOM- 20260508 LR - 20260508 IS - 1878-1861 (Electronic) IS - 1878-1861 (Linking) VI - 29 IP - 5 DP - 2026 May TI - Deriving and validating a short version of the Physical Literacy in Children Questionnaire. PG - 535-542 LID - S1440-2440(25)00528-6 [pii] LID - 10.1016/j.jsams.2025.11.018 [doi] AB - OBJECTIVES: Physical literacy encompasses individual capabilities for lifelong physical activity. The Physical Literacy in Children Questionnaire (PL-C Quest) is a 30-item pictorial tool designed to measure children's physical literacy across four domains (physical, psychological, social, cognitive). However, a shorter version may be desirable for research and practice. Therefore, the study goal was to derive a short version of the PL-C Quest. DESIGN: Observational/cross-sectional. METHODS: The PL-C Quest was completed by children aged 8-12 years (N = 620) via digital tablet. To select the most indicative items, we calculated a self-developed aggregate score consisting of nine indicators: factor loading, internal consistency, item difficulty, item-total correlation, univariate and multivariate associations with proxy-reported physical activity, eligibility for boys and for girls (test fairness/subgroup validity), and cross-cultural generalisability. Items with the highest scores in each domain (points [pts]) were selected for the short version. We analysed the association between the sum scores of the short and long version. RESULTS: The items 'speed' (22pts), 'cardiovascular endurance' (20pts), 'muscular endurance' (20pts), and 'movement skills' (5pts) were selected for the physical domain; 'motivation' (20pts), 'engagement/enjoyment' (19pts), and 'confidence' (14pts) for the psychological; 'relationships' (15pts) and 'society/culture' (14pts) for the social; 'strategy/planning' (20 pts), 'tactics' (18pts), and 'content knowledge' (17pts) for the cognitive domain. The domain-specific aggregate scores of the short version were strongly related to the respective scores of the long version (0.74 /= 75th percentile for age and sex and report dysregulated eating, to understand desired presentation, features, and barriers/facilitators to engagement. Research activities will include a needs assessment and iterative prototyping, usability testing, and refinement of the digital intervention. The second phase will be a multisite single arm open trial involving 50 adolescents who have or are at risk for overweight/obesity and report LOC and/or overeating to investigate intervention feasibility and preliminary efficacy, as well as putative treatment mechanisms and targets. CONCLUSIONS: Results of the study will inform the design of an adequately powered randomized controlled trial. The project has clear potential to significantly impact public health via development of a relevant, accessible, and scalable intervention for adolescents at risk for adverse physical and mental health outcomes. CLINICAL TRIAL REGISTRATION NUMBER: NCT06819813. CI - Copyright (c) 2025 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Goldschmidt, Andrea B AU - Goldschmidt AB AD - Department of Psychiatry, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America. Electronic address: goldscha@pitt.edu. FAU - Ortega, Adrian AU - Ortega A AD - Department of Preventive Medicine/Center for Behavioral Intervention Technologies; Northwestern Feinberg School of Medicine, Chicago, IL, United States of America. FAU - Rooper, Isabel R AU - Rooper IR AD - Department of Medical Social Sciences/Center for Behavioral Intervention Technologies; Northwestern Feinberg School of Medicine, Chicago, IL, United States of America. FAU - Obleada, Katrina T AU - Obleada KT AD - Potocsnak Family Division of Adolescent and Young Adult Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, IL, United States of America; Department of Psychiatry and Behavioral Sciences, Northwestern Feinberg School of Medicine, Chicago, IL, United States of America. FAU - Chapa, Danielle A N AU - Chapa DAN AD - Department of Psychiatry, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America. FAU - Silverberg, Basia AU - Silverberg B AD - Department of Medical Social Sciences/Center for Behavioral Intervention Technologies; Northwestern Feinberg School of Medicine, Chicago, IL, United States of America. FAU - Stalvey, Erin AU - Stalvey E AD - Department of Psychiatry, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America. FAU - Camino, Macarena Kruger AU - Camino MK AD - Department of Medical Social Sciences/Center for Behavioral Intervention Technologies; Northwestern Feinberg School of Medicine, Chicago, IL, United States of America. FAU - Levine, Michele D AU - Levine MD AD - Department of Psychiatry, Western Psychiatric Hospital, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America. FAU - Yu, Lan AU - Yu L AD - Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States of America. FAU - Eichen, Dawn M AU - Eichen DM AD - Department of Pediatrics, University of California San Diego, La Jolla, CA, United States of America. FAU - Graham, Andrea K AU - Graham AK AD - Department of Medical Social Sciences/Center for Behavioral Intervention Technologies; Northwestern Feinberg School of Medicine, Chicago, IL, United States of America. LA - eng SI - ClinicalTrials.gov/NCT06819813 GR - R01 DK136540/DK/NIDDK NIH HHS/United States PT - Clinical Trial Protocol PT - Journal Article DEP - 20251218 PL - United States TA - Contemp Clin Trials JT - Contemporary clinical trials JID - 101242342 SB - IM MH - Humans MH - Adolescent MH - *Cognitive Behavioral Therapy/methods MH - *Pediatric Obesity/prevention & control/psychology/therapy MH - Female MH - Male MH - Weight Gain MH - *Binge-Eating Disorder/therapy MH - Body Mass Index MH - Self-Control MH - Randomized Controlled Trials as Topic MH - *Mobile Applications MH - Research Design PMC - PMC13005725 MID - NIHMS2153306 OTO - NOTNLM OT - Adolescent OT - Cognitive-behavioral therapy OT - Digital OT - Loss of control eating OT - Obesity OT - Overeating OT - Self-regulation COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/21 01:48 MHDA- 2026/02/01 00:44 PMCR- 2026/03/21 CRDT- 2025/12/20 19:39 PHST- 2025/04/22 00:00 [received] PHST- 2025/12/16 00:00 [revised] PHST- 2025/12/17 00:00 [accepted] PHST- 2026/02/01 00:44 [medline] PHST- 2025/12/21 01:48 [pubmed] PHST- 2025/12/20 19:39 [entrez] PHST- 2026/03/21 00:00 [pmc-release] AID - S1551-7144(25)00386-6 [pii] AID - 10.1016/j.cct.2025.108192 [doi] PST - ppublish SO - Contemp Clin Trials. 2026 Feb;161:108192. doi: 10.1016/j.cct.2025.108192. Epub 2025 Dec 18. PMID- 41421612 OWN - NLM STAT- MEDLINE DCOM- 20260104 LR - 20260104 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 397 DP - 2026 Mar 15 TI - Differential factor effects in comorbid depressive and anxiety symptoms (CDAS): A machine learning approach to individualized mental health promotion. PG - 120883 LID - S0165-0327(25)02325-0 [pii] LID - 10.1016/j.jad.2025.120883 [doi] AB - BACKGROUND: Depression and anxiety comorbid presents greater severity than isolated symptoms. Traditional analyses often fail to capture complex interactions among multidimensional risk and protective factors. OBJECTIVE: To develop a predictive model distinguishing young Chinese adults with comorbid depressive and anxiety symptoms (CDAS) from asymptomatic individuals using machine learning within Antonovsky's salutogenic framework, identifying protective factors as Generalized Resistance Resources (GRRs) and heterogeneous risk subtypes for precision-targeted interventions. METHODS: Data from 2951 Chinese young adults (aged 19-35) from the PBICR2021 database were analyzed. Fifteen features spanning psychological, physiological, social, and environmental dimensions were selected through Lasso Regularization and the Boruta algorithm. Six machine learning models were trained and evaluated. SHAP analysis interpreted key predictive factors, with bidirectional hierarchical clustering identifying risk subtypes. Decision curve analysis validated clinical utility. RESULTS: Random Forest achieved optimal performance (AUC = 0.905, PR-AUC = 0.703), with good calibration (Brier Score = 0.097, ECE = 0.088). SHAP revealed differential association patterns: solo exercise (swimming, sports equipment), avoidant emotional regulation, obesogenic behaviors and stress were positive linked to CDAS among Chinese youth, while self-efficacy, family health, social support and healthcare access (as GRRs) were protective. Hierarchical clustering analysis of SHAP values identified three CDAS subtypes with distinct factor combination patterns. Decision curve analysis validated clinical utility within 2-67 % risk thresholds. CONCLUSIONS: Protective and risk factors showed opposite associations between comorbid versus asymptomatic groups among Chinese young adults. Protective factors operationalize Antonovsky's GRRs, while three heterogeneous subtypes support precision-targeted preventions. The 15-feature model demonstrated clinical utility within 2-67 % risk thresholds for scalable community screening. CI - Copyright (c) 2025. Published by Elsevier B.V. FAU - Hu, Sydney X AU - Hu SX AD - Kiang Wu Nursing College of Macau, Macau. Electronic address: sydney@kwnc.edu.mo. FAU - Liu, Simin AU - Liu S AD - Kiang Wu Nursing College of Macau, Macau; Medicine School of Hunan Normal University, Changsha, 410013, China. FAU - Guo, Yuanwei AU - Guo Y AD - Guangzhou Institute of Internet of Things, Guangzhou, 511462, China. LA - eng PT - Journal Article DEP - 20251218 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 SB - IM MH - Humans MH - *Machine Learning MH - Female MH - Male MH - Adult MH - Young Adult MH - *Depression/epidemiology/psychology/diagnosis MH - Comorbidity MH - *Anxiety/epidemiology/psychology/diagnosis MH - *Health Promotion/methods MH - China/epidemiology MH - Risk Factors MH - *Anxiety Disorders/epidemiology/psychology OTO - NOTNLM OT - Comorbid depressive and anxiety symptoms OT - Health resources OT - Heterogeneity OT - Machine learning OT - Salutogenic model COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/21 01:48 MHDA- 2026/01/05 00:49 CRDT- 2025/12/20 19:33 PHST- 2025/04/14 00:00 [received] PHST- 2025/11/04 00:00 [revised] PHST- 2025/12/13 00:00 [accepted] PHST- 2026/01/05 00:49 [medline] PHST- 2025/12/21 01:48 [pubmed] PHST- 2025/12/20 19:33 [entrez] AID - S0165-0327(25)02325-0 [pii] AID - 10.1016/j.jad.2025.120883 [doi] PST - ppublish SO - J Affect Disord. 2026 Mar 15;397:120883. doi: 10.1016/j.jad.2025.120883. Epub 2025 Dec 18. PMID- 41420902 OWN - NLM STAT- MEDLINE DCOM- 20260124 LR - 20260920 IS - 1873-3360 (Electronic) IS - 0306-4530 (Print) IS - 0306-4530 (Linking) VI - 185 DP - 2026 Mar TI - Systemic inflammation and ex vivo inflammatory responses in first semester university students. PG - 107729 LID - S0306-4530(25)00452-4 [pii] LID - 10.1016/j.psyneuen.2025.107729 [doi] AB - BACKGROUND: Inflammation contributes to cardiovascular and metabolic disease development. Reducing disease risk by targeting inflammation is therefore desirable in prevention research. However, circulating markers of inflammation are often difficult to detect in younger individuals. Ex vivo stimulated cytokine production offers a promising alternative measure of immune function. Yet, few studies among younger adults have used this measure to date or have assessed its reliability over time. METHODS: First-year university students (N = 110, age 18-19 years) completed two study visits, one each at the beginning and end of their first semester. Circulating cytokines and lipopolysaccharide-stimulated cytokine production were assayed at each visit; composites for each were created using IL-1beta, IL-6, and IFN-gamma. Analyses excluded participants with CRP >/= 10 mg/L. Pearson's correlations were used to examine unadjusted associations between circulating and stimulated cytokine composites, within and across visits. Multiple linear regression was then used to test concurrent associations between the circulating and stimulated cytokine composites, and the within-person stability of each measure across visits, adjusting for sex, body mass index, perceived stress, physical activity, diet quality, and sleep quality. RESULTS: Study visits occurred 13 weeks +/- 8 days apart. The circulating and stimulated cytokine composites were significantly correlated at visit 1 (r= 0.374, p<0.01) and at visit 2 (r=0.246, p = 0.02). This association remained significant in regression analyses at both visit 1 (B [95 % CI] = 0.407 [0.196, 0.617], p < 0.01) and visit 2 (B [95 % CI] = 0.312 [0.041, 0.584], p=0.03). The circulating cytokine composite at visit 1 was not significantly associated with the circulating cytokine composite at visit 2 in either correlation (r=-0.009, p=0.94) or regression (B [95 % CI] = -0.007 [-0.192, 0.179], p = 0.94) analyses. Stimulated cytokine production at visit 1 was significantly associated with stimulated cytokine production at visit 2 in both correlation (r=0.515, p<0.01) and regression analyses (B [95 % CI] = 0.497 [0.293 0.701], p<0.01). CONCLUSIONS: Contrasting with some past research, circulating cytokines were significantly associated with stimulated cytokine production in the present sample concurrently at both visits. Stimulated cytokine production was more stable within-person across visits ( approximately 13 weeks apart) compared to circulating cytokines in these students. Measurement of stimulated cytokines may be informative for understanding between-person differences in inflammation-related disease risk in younger adults, in part because they appear more stable compared to circulating cytokines. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Davis, Kristin M AU - Davis KM AD - Department of Psychology, Wayne State University, 5057 Woodward Ave, Detroit, MI 48202, United States. FAU - Wright, Molly A AU - Wright MA AD - Departmentof Biobehavioral Health, Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA 16802, United States. FAU - Engeland, Christopher G AU - Engeland CG AD - Departmentof Biobehavioral Health, Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA 16802, United States; Ross and Carol Nese University of Nursing, Pennsylvania State University, Nursing Sciences Building, University Park, PA 16802, United States. FAU - Murdock, Kyle W AU - Murdock KW AD - Departmentof Biobehavioral Health, Pennsylvania State University, 219 Biobehavioral Health Building, University Park, PA 16802, United States. Electronic address: kwm20@psu.edu. LA - eng GR - T32 AG049676/AG/NIA NIH HHS/United States GR - UL1 TR002014/TR/NCATS NIH HHS/United States PT - Journal Article DEP - 20251217 PL - England TA - Psychoneuroendocrinology JT - Psychoneuroendocrinology JID - 7612148 RN - 0 (Cytokines) RN - 0 (Interleukin-6) RN - 0 (Lipopolysaccharides) RN - 0 (Interleukin-1beta) RN - 82115-62-6 (Interferon-gamma) RN - 0 (Biomarkers) SB - IM MH - Humans MH - Female MH - Male MH - Young Adult MH - Students MH - Universities MH - Adolescent MH - *Inflammation/blood/metabolism/immunology MH - *Cytokines/blood/analysis MH - Interleukin-6/blood/analysis MH - Lipopolysaccharides/pharmacology MH - Interleukin-1beta/blood/analysis MH - Interferon-gamma/blood/analysis MH - Biomarkers/blood PMC - PMC12809777 MID - NIHMS2130853 OTO - NOTNLM OT - Immune function OT - Inflammation OT - Stimulated cytokine production OT - University students COIS- Declaration of Competing Interest none EDAT- 2025/12/20 21:50 MHDA- 2026/01/24 12:31 PMCR- 2026/01/17 CRDT- 2025/12/20 18:00 PHST- 2025/07/11 00:00 [received] PHST- 2025/10/22 00:00 [revised] PHST- 2025/12/15 00:00 [accepted] PHST- 2026/01/24 12:31 [medline] PHST- 2025/12/20 21:50 [pubmed] PHST- 2025/12/20 18:00 [entrez] PHST- 2026/01/17 00:00 [pmc-release] AID - S0306-4530(25)00452-4 [pii] AID - 10.1016/j.psyneuen.2025.107729 [doi] PST - ppublish SO - Psychoneuroendocrinology. 2026 Mar;185:107729. doi: 10.1016/j.psyneuen.2025.107729. Epub 2025 Dec 17. PMID- 41420717 OWN - NLM STAT- MEDLINE DCOM- 20260407 LR - 20261009 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 185 IP - 1 DP - 2025 Dec 20 TI - Normative reference values and factorial structure of the fundamental motor competence in Spanish preschoolers: implications for early pediatric assessment and intervention. PG - 29 LID - 10.1007/s00431-025-06663-y [doi] AB - The MOBAK-KG battery is a widely used tool for assessing motor skills in kindergartens. However, no normative data exists for Spanish-speaking children in Spain. The purpose of this study was two-fold: to develop normative reference values for the MOBAK-KG battery stratified by sex and age in children aged 4-6 years and to evaluate the factorial structure of the MOBAK-KG battery. This cross-sectional study enrolled 375 Spanish children (51.5% female). Smoothed percentile for object-movement, self-movement, and total MOBAK-KG scores were calculated using the LMS method, incorporating the gamma-lambda, mu-mu, and delta-sigma parameters according to age and sex, and confirmatory factor analysis was performed to determine the construct validity. Fit indices and parameter estimates were reported. The MOBAK-KG battery (observable items) that cover the object movement and self-movement motor competencies (latent factors) were consistently higher in boys than in girls and increased across age groups for both sexes. The results confirm the structure of the one-factor model provided the best representation of the data (chi(2)/df ratio = 1.09, CFI = 0.997; RMSEA = 0.016), and the structure of the two-factor model in all sections of the MOBAK battery also demonstrated acceptable fit (chi(2)/df = 1.33, CFI = 0.972; RMSEA = 0.036). CONCLUSION: This is the first study to provide normative MOBAK-KG data for preschool children in Spain, based on a representative sample from Northern Spain. Our results suggest that the MOBAK-KG is a valid tool to assess fundamental motor competence in children in Spain. These normative data provide pediatricians and educators with objective benchmarks to identify children at risk of motor deficits. WHAT IS KNOWN: * Fundamental motor skills (FMS) are essential for children's development and for sustaining lifelong physical activity. * MOBAK-KG is a validated tool for preschool motor competence, but normative data and structure have mainly come from German/Swiss cohorts, limiting use in Spain. WHAT IS NEW: * We provide the first Spanish norms for MOBAK-KG (ages 4-6) and confirm its psychometric structure: the one-factor model fits best, while the two-factor (OM/SM) solution remains useful for domain profiling. * We quantified age-related gains and modest sex differences and provided percentile cut-offs to support screening and early pediatric assessment and intervention. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Alonso-Martinez, Loreto AU - Alonso-Martinez L AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Avenida de Baranain s/n, 31008, Pamplona, Navarra, Spain. FAU - Ramirez-Velez, Robinson AU - Ramirez-Velez R AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Avenida de Baranain s/n, 31008, Pamplona, Navarra, Spain. FAU - Legarra-Gorgonon, Gaizka AU - Legarra-Gorgonon G AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Avenida de Baranain s/n, 31008, Pamplona, Navarra, Spain. FAU - Garcia-Alonso, Yesenia AU - Garcia-Alonso Y AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Avenida de Baranain s/n, 31008, Pamplona, Navarra, Spain. FAU - Izquierdo, Mikel AU - Izquierdo M AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Avenida de Baranain s/n, 31008, Pamplona, Navarra, Spain. mikel.izquierdo@gmail.com. FAU - Alonso-Martinez, Alicia AU - Alonso-Martinez A AD - Navarrabiomed, Hospital Universitario de Navarra (HUN), Universidad Publica de Navarra (UPNA), Instituto de Investigacion Sanitaria de Navarra (IdiSNA), Avenida de Baranain s/n, 31008, Pamplona, Navarra, Spain. LA - eng PT - Journal Article PT - Validation Study DEP - 20251220 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 SB - IM MH - Reference Values MH - Factor Analysis, Statistical MH - Spain MH - *Motor Skills/classification MH - Humans MH - Male MH - Female MH - Child, Preschool MH - Child MH - Reproducibility of Results MH - Functional Status MH - *Physical Examination/methods/standards/statistics & numerical data MH - Child Development/physiology MH - Developmental Disabilities/diagnosis MH - *Pediatrics/instrumentation/methods/standards/statistics & numerical data MH - Reference Standards MH - *Psychometrics/instrumentation/standards/statistics & numerical data MH - Sex Factors OTO - NOTNLM OT - Factorial analysis OT - MOBAK-KG OT - Motor development OT - Motor skills OT - Preschool children OT - Reference values COIS- Declarations. Ethics approval: We obtained informed consent from parents or guardians, and children provided informed permission before participating. The study protocol adhered to the principles outlined in the Helsinki Declaration and received approval from the Ethics Committee of the Universidad Publica de Navarra (PI-020/19). Consent to participate: We obtained informed consent from parents or guardians, and children provided informed permission before participating. Competing interests: The authors declare no competing interests. EDAT- 2025/12/20 12:31 MHDA- 2025/12/20 12:32 CRDT- 2025/12/20 11:07 PHST- 2025/06/17 00:00 [received] PHST- 2025/11/21 00:00 [accepted] PHST- 2025/11/18 00:00 [revised] PHST- 2025/12/20 12:32 [medline] PHST- 2025/12/20 12:31 [pubmed] PHST- 2025/12/20 11:07 [entrez] AID - 10.1007/s00431-025-06663-y [pii] AID - 10.1007/s00431-025-06663-y [doi] PST - epublish SO - Eur J Pediatr. 2025 Dec 20;185(1):29. doi: 10.1007/s00431-025-06663-y. PMID- 41420227 OWN - NLM STAT- MEDLINE DCOM- 20260124 LR - 20260604 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2025 Dec 19 TI - Maternal food literacy and health behaviors in relation to children's DMFT scores: a cross-sectional study from Turkiye. PG - 159 LID - 10.1186/s12903-025-07522-w [doi] LID - 159 AB - BACKGROUND: Oral health in childhood is influenced by parental literacy, dietary practices, and hygiene behaviors. Maternal food literacy may play a critical role in shaping children's oral health, yet this relationship remains underexplored in low- and middle-income settings. This study aimed to investigate the association between maternal food literacy and the oral health status of their children, focusing on dental caries experience (DMFT scores), oral hygiene behaviors, and sociodemographic factors. METHODS: A cross-sectional study was conducted in Dortyol, Hatay (June 2022 - February 2023) involving 113 children aged 40-120 months and their mothers. Data were collected using validated Maternal Food Literacy and Maternal Health Literacy questionnaires, alongside structured questionnaires on children's oral health behaviors, while clinical oral examinations were performed to calculate DMFT (Decayed, Missing, Filled Teeth) scores. Statistical analyses included Spearman correlation, non-parametric tests, and multiple linear regression analysis using the backward elimination method, with p < 0.05 considered statistically significant. RESULTS: The mean DMFT scores were 8.1 (+/-3.9) in children and 6.9 (+/-4.0) in mothers. While there was no significant relationship between the mother's food literacy and the child's DMFT scores (p=0.748), the mother's high health literacy was found to be associated with the child's high DMFT scores (B(95%CI) = 0.04 (0.01 - 0.08), p=0.025). Maternal education (p=0.019), employment status (p=0.003), and socioeconomic level (p=0.028) were significantly associated with DMFT. Behavioral factors-such as lack of personal toothbrush (p=0.018), low brushing frequency (p=0.002), and absence of fluoride varnish (p=0.008)-were also linked to higher caries levels. A modest but significant positive correlation was observed between maternal and child DMFT scores (r=0.264, p<0.01). CONCLUSION: Although maternal food literacy was not directly associated with children's DMFT scores in bivariate analyses, the multiple linear regression model using the backward elimination method identified higher maternal health literacy as an independent predictor of increased caries experience in children. Socioeconomic conditions and oral health behaviors were also strongly associated with caries outcomes. These findings emphasize the importance of daily oral hygiene habits in children and suggest that oral health interventions should address behavioral education within families, regardless of literacy level. CI - (c) 2025. The Author(s). FAU - Solak, Yavuzalp AU - Solak Y AUID- ORCID: 0000-0001-5274-7606 AD - Cubuk District Health Directorate, Ankara, Turkey. yavuzalp80@gmail.com. FAU - Tek, Gun Burak AU - Tek GB AUID- ORCID: 0000-0001-8203-1828 AD - Private Dental Clinic, Osmaniye, Turkey. FAU - Durmus, Hasan AU - Durmus H AUID- ORCID: 0000-0001-5719-1475 AD - Department of Public Health, Faculty of Medicine, Erciyes University, Kayseri, Turkey. FAU - Kaya, Erhan AU - Kaya E AUID- ORCID: 0000-0001-7458-3024 AD - Department of Public Health, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey. FAU - Tek, Sevim AU - Tek S AUID- ORCID: 0000-0002-3474-2681 AD - Private Dental Clinic, Osmaniye, Turkey. LA - eng PT - Journal Article TT - Influences of maternal nutrition and lifestyle factors on early childhood oral health: a systematic review of mechanisms and intervention strategies. DEP - 20251219 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Male MH - *Mothers MH - *Health Behavior MH - *Health Literacy/statistics & numerical data MH - Child, Preschool MH - Child MH - *DMF Index MH - Adult MH - Oral Hygiene/statistics & numerical data MH - Oral Health MH - *Dental Caries/epidemiology MH - Surveys and Questionnaires PMC - PMC12831266 OTO - NOTNLM OT - Child health OT - DMFT OT - Dental caries OT - Food literacy OT - Health literacy OT - Maternal behavior OT - Oral health OT - Socioeconomic status COIS- Declarations. Ethics approval and consent to participate: Ethical approval was obtained from the Ethics Committee of Hatay Mustafa Kemal University (Date: 22.04.2021, Decision No: 09) and the study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki. Participants were informed of the study details before giving written informed consent. Consent for publication: Not applicable. Competing Interests: The authors declare no competing interests. EDAT- 2025/12/20 06:31 MHDA- 2026/01/24 06:35 PMCR- 2025/12/19 CRDT- 2025/12/20 00:11 PHST- 2025/08/01 00:00 [received] PHST- 2025/12/08 00:00 [accepted] PHST- 2026/01/24 06:35 [medline] PHST- 2025/12/20 06:31 [pubmed] PHST- 2025/12/20 00:11 [entrez] PHST- 2025/12/19 00:00 [pmc-release] AID - 10.1186/s12903-025-07522-w [pii] AID - 7522 [pii] AID - 10.1186/s12903-025-07522-w [doi] PST - epublish SO - BMC Oral Health. 2025 Dec 19;26(1):159. doi: 10.1186/s12903-025-07522-w. PMID- 41420189 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251220 LR - 20251222 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 13 IP - 1 DP - 2025 Dec 19 TI - Integrating cognitive-behavioral and medical interventions for ARFID in an adolescent: a case report from Turkiye. PG - 285 LID - 10.1186/s40337-025-01463-z [doi] LID - 285 AB - This case report presents the comprehensive, multidisciplinary treatment of a 17-year-old male adolescent diagnosed with avoidant/restrictive food intake disorder (ARFID) in Turkiye. The patient developed severe food avoidance, vomiting, and significant weight loss after experiencing traumatic medical interventions, including nasogastric tube placement. His clinical course was further complicated by medical comorbidities such as achalasia, superior mesenteric artery syndrome, and gallstones, which contributed to persistent gastrointestinal discomfort and reinforced his restrictive eating behaviors. Treatment combined with outpatient Cognitive Behavioral Therapy for ARFID (CBT-AR), psychopharmacological support, family-based interventions, and ongoing medical management. CBT-AR was flexibly adapted to address the patient's fear of negative eating consequences, sensory sensitivities, and low appetite, while considering family dynamics and culturally relevant eating practices. Over a 12-month period, the patient's weight increased from 42.6 kg to 55 kg, his dietary variety expanded with the addition of 38 new foods, and his ARFID symptoms showed significant clinical improvement. This is the first documented case of CBT-AR applied in Turkiye, highlighting the feasibility and effectiveness of a combined medical-psychological approach for complex ARFID presentations. The case underscores the necessity of individualized, culturally sensitive treatment strategies and multidisciplinary collaboration in addressing ARFID, particularly in medically compromised patients. CI - (c) 2025. The Author(s). FAU - Ogutlu, Hakan AU - Ogutlu H AUID- ORCID: 0000-0002-1325-446X AD - Department of Child and Adolescent Psychiatry, Cognitive Behavioral Psychotherapies Association, Karum Is Merkezi Iran Caddesi No: 21 06680 Gaziosmanpasa Mah. 06680 Cankaya Ankara, Ankara, Turkey. hogutlu@gmail.com. AD - Department of Child and Adolescent Psychiatry, University College Dublin, Dublin, Ireland. hogutlu@gmail.com. FAU - Tiryaki, Ibrahim AU - Tiryaki I AD - Department of Child and Adolescent Psychiatry, Sultan 1. Murat State Hospital, Edirne, Turkey. FAU - Kasak, Meryem AU - Kasak M AD - Department of Child and Adolescent Psychiatry, University of Health Sciences, Ankara Etlik City Hospital, Ankara, Turkey. FAU - Turkcapar, Hakan AU - Turkcapar H AD - Department of Psychology, Social Sciences University of Ankara, Ankara, Turkey. FAU - Eddy, Kamyrn T AU - Eddy KT AD - Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. FAU - Thomas, Jennifer J AU - Thomas JJ AD - Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. LA - eng PT - Journal Article DEP - 20251219 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC12717682 OTO - NOTNLM OT - ARFID OT - Adolescent OT - Avoidant/restrictive food intake disorder OT - CBT-AR OT - Case report OT - Medical complications OT - Turkey COIS- Declarations. Ethics approval and consent to participate: As this is a single case report, formal ethical approval was not required. Written informed consent for participation and publication of identifying clinical details was obtained from the patient and his legal guardians. Consent for publication: Written informed consent for publication of this case was obtained from the patient and his legal guardians. Competing interests: The authors declare no competing interests. EDAT- 2025/12/20 06:31 MHDA- 2025/12/20 06:32 PMCR- 2025/12/19 CRDT- 2025/12/20 00:04 PHST- 2025/07/23 00:00 [received] PHST- 2025/11/09 00:00 [accepted] PHST- 2025/12/20 06:32 [medline] PHST- 2025/12/20 06:31 [pubmed] PHST- 2025/12/20 00:04 [entrez] PHST- 2025/12/19 00:00 [pmc-release] AID - 10.1186/s40337-025-01463-z [pii] AID - 1463 [pii] AID - 10.1186/s40337-025-01463-z [doi] PST - epublish SO - J Eat Disord. 2025 Dec 19;13(1):285. doi: 10.1186/s40337-025-01463-z. PMID- 41419065 OWN - NLM STAT- MEDLINE DCOM- 20260104 LR - 20260104 IS - 1573-2517 (Electronic) IS - 0165-0327 (Linking) VI - 397 DP - 2026 Mar 15 TI - The configurational influence mechanism of risky behaviors among adolescents: A combined effect analysis of neuroticism, depression, anxiety, eating behavior, alcohol consumption, and quality of life. PG - 120917 LID - S0165-0327(25)02359-6 [pii] LID - 10.1016/j.jad.2025.120917 [doi] AB - BACKGROUND: This study is based on data from the 2021 China Residents' Mental Health and Behavioral Survey (PBICR) conducted by the School of Public Health at Peking University. It focuses on the multifaceted mechanisms underlying adolescent health-risk behaviors, overcoming the explanatory limitations of traditional linear models, and exploring the asymmetric interactions between risk and protective factors. METHODS: A full sample of 560 middle school students (59.7 % female, 74.7 % urban) was used. Four-stage analysis was conducted: t-tests/chi-square tests to reveal demographic differences; Pearson correlation analysis to assess variable associations; structural equation modeling to validate path effects; and fuzzy set qualitative comparative analysis (fsQCA) to identify conditional configurations. RESULTS: Males had higher health-related quality of life (p = 0.027) and significantly higher drinking rates (p = 0.004). Health-related quality of life was the core protective factor (beta = -0.199), with depression exhibiting both direct (beta = 0.243) and mediating (beta = 0.085) pathways. fsQCA identified four configurations: high-risk groups driven by depression + alcohol consumption, and low-risk groups with foundational protective factors (dominated by health-related quality of life) + enhanced protective factors (health-related quality of life + high neuroticism). CONCLUSION: This study indicates that a higher quality of healthy living serves as a core protective factor against adolescent health risks, while depression and alcohol consumption form overlapping risks. Accordingly, it is recommended to establish a three-tiered prevention system: implement universal health education programs, conduct targeted interventions for depression and alcohol-related issues, and utilize digital tools to dynamically monitor changes in healthy living quality and risk factors, thereby achieving precision prevention. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Yang, Li AU - Yang L AD - School of Management, Shandong Second Medical University, No.7166 Baotong West Street, Weifang, Shandong, 261053, China. FAU - Zhu, Shuai-Hao AU - Zhu SH AD - School of Management, Shandong Second Medical University, No.7166 Baotong West Street, Weifang, Shandong, 261053, China. FAU - Zhang, Yi AU - Zhang Y AD - Affiliated Hospital of Shandong Second Medical University, No. 2428 Yuhe Road, Weifang, Shandong, 261033, China. FAU - Zhang, Ju-Feng AU - Zhang JF AD - School of Management, Shandong Second Medical University, No.7166 Baotong West Street, Weifang, Shandong, 261053, China. FAU - Wang, Dan AU - Wang D AD - School of Basic Medical Sciences, Shandong Second Medical University, No.7166 Baotong West Street, Weifang, Shandong, 261053, China. Electronic address: helloyangli@163.com. LA - eng PT - Journal Article DEP - 20251217 PL - Netherlands TA - J Affect Disord JT - Journal of affective disorders JID - 7906073 SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - *Quality of Life/psychology MH - *Neuroticism MH - China/epidemiology MH - *Depression/psychology/epidemiology MH - *Risk-Taking MH - *Alcohol Drinking/psychology/epidemiology MH - *Anxiety/psychology/epidemiology MH - *Feeding Behavior/psychology MH - *Adolescent Behavior/psychology OTO - NOTNLM OT - Anxiety OT - Big Five personality traits OT - Depression OT - Healthy risk behaviors COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/20 00:40 MHDA- 2026/01/05 00:49 CRDT- 2025/12/19 19:34 PHST- 2025/09/07 00:00 [received] PHST- 2025/11/27 00:00 [revised] PHST- 2025/12/13 00:00 [accepted] PHST- 2026/01/05 00:49 [medline] PHST- 2025/12/20 00:40 [pubmed] PHST- 2025/12/19 19:34 [entrez] AID - S0165-0327(25)02359-6 [pii] AID - 10.1016/j.jad.2025.120917 [doi] PST - ppublish SO - J Affect Disord. 2026 Mar 15;397:120917. doi: 10.1016/j.jad.2025.120917. Epub 2025 Dec 17. PMID- 41418239 OWN - NLM STAT- MEDLINE DCOM- 20251219 LR - 20251219 IS - 0030-9982 (Print) IS - 0030-9982 (Linking) VI - 75 IP - 12 DP - 2025 Dec TI - Assessment of genetic variation(s) in BBS10, BBS6, and BBS12 in a family from Sindh, Pakistan diagnosed with Bardet-Biedl Syndrome. PG - 1908-1913 LID - 10.47391/JPMA.25-21343 [doi] AB - OBJECTIVE: To analyse the symptoms of Bardet-Biedl Syndrome, and to check the association of BBS10 (Bardet-Biedl syndrome 10 gene), BBS6 (Bardet-Biedl syndrome 6 gene) and BBS12 (Bardet-Biedl syndrome 12 gene) with the pathogenesis of Bardet-Biedl Syndrome. METHODS: The case-control study was conducted in Karachi in 2019-20, and comprised Bardet-Biedl Syndrome patients and healthy controls from the same family. Blood was drawn from all the subjects for deoxyribonucleic acid extraction. Genotyping was performed by conventional and tetra primer amplification refractory mutation system polymerase chain reaction (T-ARMS-PCR) to identify the possible genetic variations. To validate the results, samples were randomly selected and sent for sequencing. Data was analysed using SPSS 20, while sequencing data was analysed using the Molecular Evolutionary Genetics Analysis X software. RESULTS: Of the 20 subjects with mean age 15.8+/-5.09 years (range: 9-25 years), 8(40%) were cases and 12(60%) were controls. The male-to-female ratio was 1:1. Pedigree analysis revealed that the pattern of inheritance was autosomal recessive. All the 8(100%) cases were obese compared to the controls. Truncal obesity, polydactyly, learning impairment and dysmorphic features, renal pain, olfactory dysfunction, respiratory tract infection and dysphasia were observed in all the 8(100%) cases. The globally reported genetic variants of BBS10 (rs1057516628 and rs1489342987) and BBS12 (rs121918327 and rs587777802) did not indicate any association with the clinical phenotype in the family concerned. The genetic variations of BBS6 (rs1547, rs1545 and rs1351192494), BBS12 (rs309370, rs2292493) and a BBS10 variant (rs35676114) had significant association with the disease. CONCLUSIONS: The genetic variations showed confounding effects of BBS10, BBS6 and BBS12 genes which might indicate the epistatic effects of other variants present on different loci. FAU - Fatima, Sehrish AU - Fatima S AD - Dr. A. Q. Khan Institute of Biotechnology and Genetic Engineering (KIBGE), University of Karachi, Karachi, Pakistan. FAU - Amjad, Maryam AU - Amjad M AD - Dr. A. Q. Khan Institute of Biotechnology and Genetic Engineering (KIBGE), University of Karachi, Karachi, Pakistan. FAU - Zehra, Faiza AU - Zehra F AD - Dr. A. Q. Khan Institute of Biotechnology and Genetic Engineering (KIBGE), University of Karachi, Karachi, Pakistan. FAU - Sher, Khalid AU - Sher K AD - Department of Neurology, Jinnah Postgraduate Medical Centre, Karachi, Pakistan. FAU - Kumar, Suneel AU - Kumar S AD - Department of Neurology, Jinnah Postgraduate Medical Centre, Karachi, Pakistan. FAU - Saleem, Saima AU - Saleem S AD - Dr. A. Q. Khan Institute of Biotechnology and Genetic Engineering (KIBGE), University of Karachi, Karachi, Pakistan. FAU - Zehra, Sitwat AU - Zehra S AD - Dr. A. Q. Khan Institute of Biotechnology and Genetic Engineering (KIBGE), University of Karachi, Karachi, Pakistan. LA - eng PT - Journal Article PL - Pakistan TA - J Pak Med Assoc JT - JPMA. The Journal of the Pakistan Medical Association JID - 7501162 RN - 0 (BBS10 protein, human) RN - EC 3.6.1.- (Group II Chaperonins) RN - EC 3.6.1.- (Chaperonins) SB - IM MH - Humans MH - *Bardet-Biedl Syndrome/genetics MH - Pakistan MH - Female MH - Male MH - Case-Control Studies MH - Adult MH - Adolescent MH - Child MH - Young Adult MH - Pedigree MH - Genetic Variation MH - Group II Chaperonins/genetics MH - *Chaperonins/genetics OTO - NOTNLM OT - Bardet-Biedl syndrome, BBS10, BBS6, BBS12, Genetic variations, Polymorphism. EDAT- 2025/12/19 18:32 MHDA- 2025/12/19 18:33 CRDT- 2025/12/19 16:23 PHST- 2025/12/19 18:33 [medline] PHST- 2025/12/19 18:32 [pubmed] PHST- 2025/12/19 16:23 [entrez] AID - 10.47391/JPMA.25-21343 [doi] PST - ppublish SO - J Pak Med Assoc. 2025 Dec;75(12):1908-1913. doi: 10.47391/JPMA.25-21343. PMID- 41417391 OWN - NLM STAT- MEDLINE DCOM- 20251219 LR - 20260128 IS - 1806-9460 (Electronic) IS - 1516-3180 (Print) IS - 1516-3180 (Linking) VI - 144 IP - 1 DP - 2025 TI - Cut-off point for diagnosing thoraco-lumbo-pelvic rotation range hypomobility through the leg lateral reach test in chronic low back pain: a cross-sectional study. PG - e2024500 LID - S1516-31802026000100603 [pii] LID - 10.1590/1516-3180.2024.0500.R1.08092025 [doi] LID - e2024500 AB - BACKGROUND: Studies have proposed using the leg lateral reach test (LLRT). However, they did not establish a cut-off point for testing. OBJECTIVE: To establish a cut-off point for the thoraco-lumbo-pelvic rotation range using the LLRT in patients with chronic low back pain. DESIGN AND SETTING: Cross-sectional study conducted in Buriticupu, Maranhao, Brazil. METHODS: In the chronic low back pain group (LBPG, n = 35), we included patients aged 18 to 59 years, of both sexes, with scores /= 3 on the Roland-Morris Disability Questionnaire, and pain levels >/= 3 on the Numeric Pain Rating Scale. In the healthy control group (HCG, n = 35), the patients had the same characteristics (except for pain and disability). We used receiver operating characteristic curves to check the rate of true versus false positives in different LLRT ranges of motion and found the best LLRT cut-off point using the following mathematical model: (1 - sensitivity)2 + (1 - specificity)2. RESULTS: The sample was mainly composed of females (HCG = 65.71%; LBPG = 82.85%, P = 0.101), and 68.42% of the characteristics (13 of 19 comparisons between groups) showed a significant difference (P /= 0.5). The cut-off value for ideal sensitivity and specificity was /= 3 inadequate micronutrient intakes compared to the lowest tertile. For the original PHDI, children in the highest tertile had 30% lower odds (OR: 0.70; 95% CI: 0.32-1.54). CONCLUSION: The PHDI-C is linked to better nutritional adequacy than the original PHDI. Further research is needed to validate the PHDI-C in terms of environmental sustainability. FAU - Fabios, Elise AU - Fabios E AD - Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, Pamplona, Spain. FAU - Zazpe, Itziar AU - Zazpe I AD - Department of Nutrition, Food Science and Physiology, School of Pharmacy, University of Navarra, Pamplona, Spain. AD - Biomedical Research Centre Network on Obesity and Nutrition (CIBERobn), Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain. AD - IdiSNA, Instituto de Investigacion Sanitaria de Navarra, Pamplona, Spain. FAU - Santiago, Susana AU - Santiago S AD - Department of Nutrition, Food Science and Physiology, School of Pharmacy, University of Navarra, Pamplona, Spain. AD - IdiSNA, Instituto de Investigacion Sanitaria de Navarra, Pamplona, Spain. FAU - Garcia, Silvia AU - Garcia S AD - Biomedical Research Centre Network on Obesity and Nutrition (CIBERobn), Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain. AD - Research Group on Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, Palma de Mallorca, Spain. AD - Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca, Spain. FAU - Martinez-Gonzalez, Miguel Angel AU - Martinez-Gonzalez MA AD - Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, Pamplona, Spain. AD - Biomedical Research Centre Network on Obesity and Nutrition (CIBERobn), Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain. AD - IdiSNA, Instituto de Investigacion Sanitaria de Navarra, Pamplona, Spain. FAU - Martin-Calvo, Nerea AU - Martin-Calvo N AUID- ORCID: 0000-0001-7549-1455 AD - Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, Pamplona, Spain. nmartincalvo@unav.es. AD - Biomedical Research Centre Network on Obesity and Nutrition (CIBERobn), Physiopathology of Obesity and Nutrition, Institute of Health Carlos III, Madrid, Spain. nmartincalvo@unav.es. AD - IdiSNA, Instituto de Investigacion Sanitaria de Navarra, Pamplona, Spain. nmartincalvo@unav.es. LA - eng PT - Journal Article DEP - 20251219 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Child, Preschool MH - Cross-Sectional Studies MH - Male MH - Female MH - *Micronutrients/administration & dosage MH - *Nutritional Status MH - *Diet, Healthy/statistics & numerical data MH - Nutritional Requirements MH - *Diet MH - *Child Nutritional Physiological Phenomena MH - *Recommended Dietary Allowances PMC - PMC12717126 OTO - NOTNLM OT - EAT-Lancet diet OT - Micronutrient adequacy OT - PHDI-C OT - Planetary health diet index OT - SENDO Cohort COIS- Declarations. Conflict of interest: The authors declare that they have no competing interests. Ethical approval: The SENDO project adheres to the rules of the Declaration of Helsinki on the ethical principles for medical research in human beings. This study was approved by the Ethics Committee for Clinical Research of Navarra (P. 2016/122). An informed consent was obtained during the recruitment from all participants' parents. Consent for publication: Not applicable. EDAT- 2025/12/19 15:03 MHDA- 2026/06/27 00:49 PMCR- 2025/12/19 CRDT- 2025/12/19 11:26 PHST- 2025/05/13 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2026/06/27 00:49 [medline] PHST- 2025/12/19 15:03 [pubmed] PHST- 2025/12/19 11:26 [entrez] PHST- 2025/12/19 00:00 [pmc-release] AID - 10.1007/s00394-025-03858-9 [pii] AID - 3858 [pii] AID - 10.1007/s00394-025-03858-9 [doi] PST - epublish SO - Eur J Nutr. 2025 Dec 19;65(1):16. doi: 10.1007/s00394-025-03858-9. PMID- 41416345 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251219 LR - 20251221 IS - 2001-8525 (Print) IS - 2001-8525 (Electronic) IS - 2001-8525 (Linking) VI - 13 IP - 1 DP - 2026 TI - Relation of changes in PEF and FEV(1) during bronchodilation in children. PG - 2604396 LID - 10.1080/20018525.2025.2604396 [doi] LID - 2604396 AB - INTRODUCTION: Asthma diagnosis can be confirmed through the observation of significant bronchodilator response (BDR) measured by peak expiratory flow (PEF) during home monitoring or by forced expiratory volume in one second (FEV(1)) with spirometry in a clinical setting. AIM: To use salbutamol administration after an exercise challenge test in children as a model of bronchodilation to assess how well relative change in PEF reflects improvement in lung function, as defined by increase in FEV(1). METHODS: We retrospectively studied 326 free running exercise challenge tests with spirometry in children 6-16 years old. To assess congruency and differences between relative changes in PEF and FEV(1) during bronchodilation, a regression analysis was performed, and a Bland - Altman plot was constructed. ROC analysis, sensitivity, specificity, positive and negative predictive values and Cohen's kappa coefficient were used to analyze how accurately increases in PEF predict an increase of 12% & 0.2 L in FEV(1). RESULTS: Relative change in PEF was, on average, greater than that in FEV(1). In ROC analysis, the area under the curve for PEF change was 0.837, with an optimal operating point of 14.5% (95% CI, 7.5-21.0%). The currently recommended cut-off for handheld PEF meters during home monitoring (15% increase) yielded a sensitivity of 71% and a specificity of 78%. The highest kappa value was observed at a 20% PEF cut-off. CONCLUSION: Increase in PEF is not an accurate measure of BDR compared with increase in FEV(1). The patient populations identified using PEF and FEV(1) criteria differ markedly. CI - (c) 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. FAU - Csonka, Leon L AU - Csonka LL AD - Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. FAU - Tikkakoski, Antti AU - Tikkakoski A AD - Department of Clinical Physiology and Nuclear Medicine, Tampere University Hospital, Tampere, Finland. FAU - Tikkakoski, Anna P AU - Tikkakoski AP AD - Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. FAU - Karjalainen, Jussi AU - Karjalainen J AD - Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. AD - Allergy Centre, Tampere University Hospital, Tampere, Finland. FAU - Lehtimaki, Lauri AU - Lehtimaki L AD - Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. AD - Allergy Centre, Tampere University Hospital, Tampere, Finland. LA - eng PT - Journal Article DEP - 20251215 PL - United States TA - Eur Clin Respir J JT - European clinical respiratory journal JID - 101662134 PMC - PMC12710255 OTO - NOTNLM OT - Asthma OT - PEF OT - bronchodilation OT - diagnostics OT - home monitoring OT - spirometry COIS- No potential conflict of interest was reported by the author(s). EDAT- 2025/12/19 06:30 MHDA- 2025/12/19 06:31 PMCR- 2025/12/15 CRDT- 2025/12/19 05:01 PHST- 2025/12/19 06:31 [medline] PHST- 2025/12/19 06:30 [pubmed] PHST- 2025/12/19 05:01 [entrez] PHST- 2025/12/15 00:00 [pmc-release] AID - 2604396 [pii] AID - 10.1080/20018525.2025.2604396 [doi] PST - epublish SO - Eur Clin Respir J. 2025 Dec 15;13(1):2604396. doi: 10.1080/20018525.2025.2604396. eCollection 2026. PMID- 41416291 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251219 LR - 20251221 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 11 DP - 2025 Nov TI - Comparison of Stool Myeloperoxidase Levels and Their Association With Clinical Parameters in Children With Severe Acute Malnutrition, Children With Moderate Acute Malnutrition, and Healthy Children. PG - e97072 LID - 10.7759/cureus.97072 [doi] LID - e97072 AB - BACKGROUND: Environmental enteropathy (EE) is a sub-clinical inflammatory condition of the intestine that contributes to malabsorption, growth failure, and impaired immunity in children from low-income countries. Stool myeloperoxidase (MPO) is a potential biomarker for assessing gut inflammation in malnourished children. The aim of the study was to estimate the MPO level in children with severe acute malnutrition (SAM), children with moderate acute malnutrition (MAM), and healthy children, and its association with clinical parameters. METHODS: This prospective observational study was conducted from September 2018 to May 2020 in a tertiary care teaching hospital in northern India. Inclusion criteria were children aged 2-60 months admitted/attending the outpatient department with WHO criteria of SAM and MAM, and age and sex matched healthy children. Variables recorded were age, sex, and socioeconomic status, and clinical data, including detailed history, anthropometry, systemic examination, and laboratory investigations. Human MPO enzyme-linked immunosorbent assay (ELISA) Kit (ELK1062; ELK Biotechnology Co., Ltd, Wuhan, China) was used for estimating stool MPO levels. The levels were measured according to the manufacturer's guidelines, and the detection level ranged from 1.57 ng/ml to 100 ng/ml. A p-value <0.05 was considered significant. Receiver operating characteristic curve (ROC) analysis was performed to determine the predictive value of MPO for gut inflammation. RESULTS: A total of 61 SAM, 25 MAM, and 15 healthy children were included. Median MPO levels were significantly higher in SAM (20,000 ng/g) compared to MAM (9,500 ng/g, p=0.004) and healthy children (8,250 ng/g, p<0.001). MPO levels were not significantly associated with diarrhea (p=0.82), edema (p=0.83), or stunting (p=0.86). ROC analysis identified a cut-off MPO level of 6,875 ng/g, yielding 98% sensitivity and 93% specificity for differentiating gut inflammation in SAM versus healthy children with an area under the curve (AUC) of 0.84 (95%CI, 0.77-0.93) (p=0.000). CONCLUSION: SAM exhibited significantly elevated MPO levels without clinical correlation, indicating sub-clinical gut inflammation. MPO shows promise as a sensitive biomarker but requires validation in larger, longitudinal, and multi-biomarker studies. CI - Copyright (c) 2025, John et al. FAU - John, Charu AU - John C AD - Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IND. FAU - Rao, Sunil Kumar AU - Rao SK AD - Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IND. FAU - Saroj, Anil K AU - Saroj AK AD - Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IND. FAU - Srivastava, Chandradeep AU - Srivastava C AD - Pediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IND. FAU - Nath, Gopal AU - Nath G AD - Microbiology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, IND. LA - eng PT - Journal Article DEP - 20251117 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12710673 OTO - NOTNLM OT - fecal biomarker OT - gut inflammation OT - moderate acute malnutrition OT - myeloperoxidase OT - sever acute malnutrition COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. Ethical Committee, Banaras Hindu University Institute of Medical Sciences issued approval Dean/EC/2020/2019, dated December 7, 2020. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/12/19 06:31 MHDA- 2025/12/19 06:32 PMCR- 2025/11/17 CRDT- 2025/12/19 05:01 PHST- 2025/11/17 00:00 [accepted] PHST- 2025/12/19 06:32 [medline] PHST- 2025/12/19 06:31 [pubmed] PHST- 2025/12/19 05:01 [entrez] PHST- 2025/11/17 00:00 [pmc-release] AID - 10.7759/cureus.97072 [doi] PST - epublish SO - Cureus. 2025 Nov 17;17(11):e97072. doi: 10.7759/cureus.97072. eCollection 2025 Nov. PMID- 41415879 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251219 LR - 20251221 IS - 2326-9901 (Electronic) IS - 2326-9901 (Linking) VI - 12 IP - 4 DP - 2025 TI - A systematic computational analysis of pharmacological options in neuroinflammatory-induced autism spectrum disorder in children: A potential for drug repositioning. PG - e99010079 LID - 10.14440/jbm.0219 [doi] LID - e99010079 AB - BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by deficits in social communication and the presence of restricted or repetitive behaviors. Although its underlying pathophysiological mechanisms remain unclear, growing evidence indicates that neuroinflammation plays a significant role, especially in children. OBJECTIVE: This study aims to explore neuroinflammatory pathways in children aged 12 and under, with a focus on potential therapeutic opportunities through drug repositioning. METHODS: We conducted a systematic computational analysis using data from 27 studies and bioinformatics resources such as DrugBank and PubChem, identifying over 8,000 potential drug candidates from the initial 29 treatments retrieved from the literature. RESULTS: Key compounds such as cannabidiol, fluoxetine, and risperidone were highlighted for their broad therapeutic potential. In addition, emerging treatments, including cell-based therapies and dietary interventions, were explored. CONCLUSION: Our findings support drug repositioning as an effective strategy for developing new ASD treatments during critical developmental periods, emphasizing the need for further research to validate these pathways and the efficacy of innovative therapies. CI - Copyright: (c) 2025 Author(s). FAU - Ismail, Manel AU - Ismail M AD - Department of Health Engineering and Management, Faculty of Health and Sport Sciences, The University of Lille, Lille, Nord 59000, France. FAU - Aananou, Soukaina AU - Aananou S AD - Department of Health Engineering and Management, Faculty of Health and Sport Sciences, The University of Lille, Lille, Nord 59000, France. FAU - Foguem, Clovis AU - Foguem C AD - Univ. Lille, ULR 2694 METRICS, The University of Lille, Lille, Nord 59000, France. AD - Department of Surgery, Gastroenterology, and Emergency, Auban-Moet Hospital, Epernay, Marne 51200, France. FAU - Guinhouya, Kokou M AU - Guinhouya KM AD - Department of Neurology, Sylvanus Olympio University Hospital, Lome 99345, Togo. FAU - Dossou, Gloria T AU - Dossou GT AD - Department of Health Engineering and Management, Faculty of Health and Sport Sciences, The University of Lille, Lille, Nord 59000, France. AD - Univ. Lille, Lille University Management Lab (LUMEN) ULR 4999, The University of Lille, Lille, Nord 59000, France. FAU - Boudis, Fabio AU - Boudis F AD - Department of Health Engineering and Management, Faculty of Health and Sport Sciences, The University of Lille, Lille, Nord 59000, France. AD - Department of Medical Informatics, Lille University Hospital, Lille, Nord 59000, France. FAU - Tchedre, Kissaou AU - Tchedre K AD - Nanoscope Technologies, LLC, Bedford, Texas 76022, United States of America. FAU - Vilhelm, Christian AU - Vilhelm C AD - Department of Health Engineering and Management, Faculty of Health and Sport Sciences, The University of Lille, Lille, Nord 59000, France. AD - Univ. Lille, ULR 2694 METRICS, The University of Lille, Lille, Nord 59000, France. FAU - Guinhouya, Benjamin C AU - Guinhouya BC AD - Department of Health Engineering and Management, Faculty of Health and Sport Sciences, The University of Lille, Lille, Nord 59000, France. AD - Univ. Lille, ULR 2694 METRICS, The University of Lille, Lille, Nord 59000, France. FAU - Zitoun, Djamel AU - Zitoun D AD - Cancer Heterogeneity, Plasticity, and Resistance to Therapies (CANTHER), National Centre for Scientific Research, National Institute of Health and Medical Research, Lille University Hospital, The University of Lille, Lille, Nord 59000, France. LA - eng PT - Journal Article DEP - 20251023 PL - United States TA - J Biol Methods JT - Journal of biological methods JID - 101639022 PMC - PMC12709514 OTO - NOTNLM OT - Bioinformatics OT - Brain OT - Data science OT - Inflammation OT - Knowledge graph OT - Pharmacology OT - Youth COIS- The authors declare no conflict of interest. EDAT- 2025/12/19 06:30 MHDA- 2025/12/19 06:31 PMCR- 2025/10/23 CRDT- 2025/12/19 04:56 PHST- 2025/01/24 00:00 [received] PHST- 2025/05/05 00:00 [revised] PHST- 2025/09/01 00:00 [accepted] PHST- 2025/12/19 06:31 [medline] PHST- 2025/12/19 06:30 [pubmed] PHST- 2025/12/19 04:56 [entrez] PHST- 2025/10/23 00:00 [pmc-release] AID - 10.14440/jbm.0219 [doi] PST - epublish SO - J Biol Methods. 2025 Oct 23;12(4):e99010079. doi: 10.14440/jbm.0219. eCollection 2025. PMID- 41415843 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251219 LR - 20251221 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - The ferroform and glycoform landscape of human milk lactoferrin dissected through hybrid mass spectrometric approaches. PG - 1697081 LID - 10.3389/fnut.2025.1697081 [doi] LID - 1697081 AB - Human milk lactoferrin (hmLF), a sialic acid-rich iron-binding milk glycoprotein, is essential for infant development, playing a key role in immune defense and gut maturation. Despite its importance, the diversity of hmLF proteoforms, including the relationship between glycosylation profiles (glycoforms) and iron-binding states (ferroforms), has not been systematically characterized. To address this, we used a hybrid mass spectrometry (MS) approach, combining bottom-up glycoproteomics and ion-exchange (IEX) native MS, to analyze hmLF from three human milk donors across lactation. Bottom-up glycoproteomic results revealed that Asn642 remained predominantly not glycosylated, while Asn156 and Asn497 were frequently occupied with biantennary glycans exhibiting variable fucosylation and sialylation. Notably, glycan heterogeneity displayed a site-specific pattern, decreasing consistently in both donors over lactation. Additionally, we used an IEX-native MS strategy to obtain a full picture of the glyco- and ferroforms coexisting in human milk at late lactation stages. IEX separated LF molecules primarily by iron content rather than glycan composition, resulting in five LF fractions with varying iron-loading and glycosylation levels. Native MS full proteoform profiling of these fractions validated that most LF molecules were glycosylated at two of the three available sites, likely Asn156 and Asn497, yet revealed a minor pool of proteoforms glycosylated at all three sites. Careful evaluation of individual fractions and compiled data revealed no clear correlation between ferroform and N-glycosylation profiles. These findings provide a detailed overview of hmLF molecular heterogeneity, offering valuable insights for advancing nutritional product development and understanding this bioactive protein's functional role. CI - Copyright (c) 2025 Zhu, Bauza-Martinez, Gouw, Zhao, Heck, Stahl, Reiding and Dingess. FAU - Zhu, Jing AU - Zhu J AD - Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, Netherlands. AD - Netherlands Proteomics Center, Utrecht, Netherlands. AD - Institute of Biotechnology and Health, Beijing Academy of Science and Technology, Beijing, China. FAU - Bauza-Martinez, Julia AU - Bauza-Martinez J AD - Skid Visual Science, Ibiza, Spain. FAU - Gouw, Joost W AU - Gouw JW AD - Danone Research & Innovation, Utrecht, Netherlands. FAU - Zhao, Xianfeng AU - Zhao X AD - Health & Science, Open Science Research Center, Danone Nutricia, Shanghai, China. FAU - Heck, Albert J R AU - Heck AJR AD - Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, Netherlands. AD - Netherlands Proteomics Center, Utrecht, Netherlands. FAU - Stahl, Bernd AU - Stahl B AD - Health & Science, Open Science Research Center, Danone Nutricia, Shanghai, China. AD - Department of Chemical Biology and Drug Discovery, Utrecht Institute for Pharmaceutical Sciences Utrecht University, Utrecht, Netherlands. FAU - Reiding, Karli R AU - Reiding KR AD - Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, Netherlands. AD - Netherlands Proteomics Center, Utrecht, Netherlands. FAU - Dingess, Kelly A AU - Dingess KA AD - Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, Netherlands. AD - Netherlands Proteomics Center, Utrecht, Netherlands. AD - Health & Science, Open Science Research Center, Danone Nutricia, Shanghai, China. LA - eng PT - Journal Article DEP - 20251203 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12709628 OTO - NOTNLM OT - bioactive protein OT - glycoproteomics OT - human milk OT - ion-exchange OT - lactoferrin (lf) OT - mass spectrometry OT - native mass spectrometry OT - proteoform characterization COIS- JB-M is the founder of Skid Visual Science. JG, BS and KD were Danone Global Research & Innovation Center B.V. XZ was employed by Danone Nutricia. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/19 06:30 MHDA- 2025/12/19 06:31 PMCR- 2025/12/03 CRDT- 2025/12/19 04:56 PHST- 2025/09/01 00:00 [received] PHST- 2025/10/28 00:00 [revised] PHST- 2025/11/12 00:00 [accepted] PHST- 2025/12/19 06:31 [medline] PHST- 2025/12/19 06:30 [pubmed] PHST- 2025/12/19 04:56 [entrez] PHST- 2025/12/03 00:00 [pmc-release] AID - 10.3389/fnut.2025.1697081 [doi] PST - epublish SO - Front Nutr. 2025 Dec 3;12:1697081. doi: 10.3389/fnut.2025.1697081. eCollection 2025. PMID- 41414774 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20260307 IS - 1536-4801 (Electronic) IS - 0277-2116 (Linking) VI - 82 IP - 3 DP - 2026 Mar TI - CO(2) emissions, costs, and satisfaction in telemedicine versus face-to-face follow-up of pediatric celiac disease. PG - 727-733 LID - 10.1002/jpn3.70302 [doi] AB - OBJECTIVES: Patient travel accounts for around 10% of healthcare-related greenhouse gas emissions. Telemedicine (TM) may contribute to reducing emissions. This study aimed to compare CO(2) emissions, costs, and satisfaction associated with TM versus face-to-face (FTF) visits for follow-up of pediatric patients with celiac disease (CeD). METHODS: CeD patients (2-16 years), attending follow-up visits, were invited to choose between FTF or TM visits via Google Meet. Data on carbon footprint, cost, usability, and satisfaction (telehealth usability questionnaire [TUQ]), and dietary adherence (celiac dietary adherence test [CDAT]) were collected using Google Forms. RESULTS: Between March 2023 and November 2024, 300 patients were invited and 131 included (58 TM, 73 FTF). Baseline characteristics were similar (gender, age, and respondent). CDAT scores were comparable (p = 0.9). Compared to FTF, TM visits were shorter (30 vs. 75 min), with lower CO(2) emissions (0.08 vs. 24.00 kg), fewer lost workdays (18.9% vs. 81.1%), and reduced costs (euro0.55 vs. euro15.7; all p < 0.001); satisfaction was high except for "reliability" (median score: 16). CONCLUSIONS: TM is a sustainable alternative for CeD follow-up, reducing CO(2) emissions, costs, and time. High satisfaction supports broader TM implementation in line with environmental goals. CI - (c) 2025 European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Damiani, Denise AU - Damiani D AD - DISCO Department, Division of Pediatrics, Polytechnic University of Marche, Ancona, Italy. FAU - Monachesi, Chiara AU - Monachesi C AUID- ORCID: 0000-0002-3117-2652 AD - DISCO Department, Division of Pediatrics, Polytechnic University of Marche, Ancona, Italy. FAU - Correani, Alessio AU - Correani A AD - Department of Odontostomatologic and Specialized Clinical Sciences, Polytechnic University of Marche, Ancona, Italy. FAU - Ascani, Milena AU - Ascani M AD - DISCO Department, Division of Pediatrics, Polytechnic University of Marche, Ancona, Italy. FAU - Pjetraj, Dorina AU - Pjetraj D AD - DISCO Department, Division of Pediatrics, Polytechnic University of Marche, Ancona, Italy. FAU - Quattrini, Sara AU - Quattrini S AD - DISCO Department, Division of Pediatrics, Polytechnic University of Marche, Ancona, Italy. FAU - Franceschini, Elisa AU - Franceschini E AD - DISCO Department, Division of Pediatrics, Polytechnic University of Marche, Ancona, Italy. FAU - Gatti, Simona AU - Gatti S AD - DISCO Department, Division of Pediatrics, Polytechnic University of Marche, Ancona, Italy. FAU - Catassi, Carlo AU - Catassi C AD - DISCO Department, Division of Pediatrics, Polytechnic University of Marche, Ancona, Italy. AD - Mucosal Immunology and Biology Research Center, Massachusetts General Hospital-Harvard Medical School, Boston, Massachusetts, USA. FAU - Lionetti, Elena AU - Lionetti E AD - DISCO Department, Division of Pediatrics, Polytechnic University of Marche, Ancona, Italy. LA - eng GR - None/ PT - Comparative Study PT - Journal Article DEP - 20251218 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 RN - 142M471B3J (Carbon Dioxide) SB - IM MH - Humans MH - Child MH - Female MH - *Telemedicine/economics MH - Male MH - *Celiac Disease/diet therapy/economics MH - Adolescent MH - *Patient Satisfaction/statistics & numerical data MH - *Carbon Dioxide/analysis MH - Child, Preschool MH - Follow-Up Studies MH - Carbon Footprint OTO - NOTNLM OT - carbon footprint OT - digital health OT - healthcare sustainability OT - pediatric telehealth EDAT- 2025/12/19 06:31 MHDA- 2026/03/07 18:37 CRDT- 2025/12/19 02:25 PHST- 2025/10/27 00:00 [revised] PHST- 2025/08/25 00:00 [received] PHST- 2025/11/04 00:00 [accepted] PHST- 2026/03/07 18:37 [medline] PHST- 2025/12/19 06:31 [pubmed] PHST- 2025/12/19 02:25 [entrez] AID - 10.1002/jpn3.70302 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Mar;82(3):727-733. doi: 10.1002/jpn3.70302. Epub 2025 Dec 18. PMID- 41413499 OWN - NLM STAT- MEDLINE DCOM- 20260124 LR - 20260125 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2025 Dec 18 TI - Measuring screen time among adolescents: test-retest reliability of HBSC questionnaire items across two countries. PG - 290 LID - 10.1186/s12889-025-25950-9 [doi] LID - 290 AB - BACKGROUND: Increasing recreational screen time among adolescents is linked to adverse health outcomes like obesity and poor mental health. This highlights the need for reliable tools to monitor screen-based behaviours. The present study examined the test-retest reliability of recreational screen-time items from the Health Behaviour in School-aged Children (HBSC) questionnaire across culturally diverse adolescent populations. METHODS: Using a test-retest design with a 2-3 week interval, we collected data from 750 adolescents (48.8% boys, mean age 15.29 years, SD 2.37) in Mexico (n = 233, aged 10-15y) and Czechia (n = 517, aged 10-18y) in 2022-2024. Self-reported time spent on gaming, social networking, video watching, and internet browsing were evaluated using Intraclass Correlation Coefficients (ICCs) for continuous measures and Cohen's kappa for dichotomized outcomes (< 2 vs. >/= 2 h/day), with analyses stratified by age, gender, and country. RESULTS: Gaming and social networking demonstrated moderate-to-good reliability (ICC = 0.70-0.74, kappa = 0.64-0.65, 82-83% unchanged responses). Video watching and browsing were less stable (ICC = 0.52-0.63, kappa = 0.41-0.47). Czech primary school students exhibited the highest consistency (ICC = 0.76-0.81), while Mexican students completed the items with lower reliability (ICC = 0.43-0.54). Older adolescents (16-18 years) and girls reported greater stability for gaming and social networking, respectively. CONCLUSIONS: The screen-time items tested in this study showed acceptable test-retest reliability across countries, age groups, and sexes, particularly for gaming and social networking. These findings support their use in global adolescent health surveillance, while highlighting the need for refinement of less stable domains such as video watching and internet browsing. Given that samples were not nationally representative, findings should be interpreted within these specific contexts. Future research should enhance measurement precision and inform public health efforts to monitor and address screen-time related health risks. CI - (c) 2025. The Author(s). FAU - Matusova, Michaela AU - Matusova M AD - Faculty of Physical Culture, Palacky University Olomouc, Olomouc, Czech Republic. FAU - Maracek, Marek AU - Maracek M AD - Faculty of Physical Culture, Palacky University Olomouc, Olomouc, Czech Republic. FAU - Pavelka, Jan AU - Pavelka J AD - Centre of Sports Activities, Brno University of Technology, Brno, Czech Republic. FAU - Ng, Kwok AU - Ng K AD - Physical Activity for Health Research Centre, Department of Physical Education and Sport Sciences, Health Research Institute, University of Limerick, Limerick, Ireland. AD - Faculty of Education, University of Turku, Turku, Finland. AD - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, Lithuania. FAU - Medina, Catalina AU - Medina C AD - National Institute of Public Health, Cuernavaca, Morelos, Mexico. FAU - Tylsarova, Nikola AU - Tylsarova N AD - Faculty of Physical Culture, Palacky University Olomouc, Olomouc, Czech Republic. FAU - Bucksch, Jens AU - Bucksch J AD - Department of Prevention and Health Promotion, Faculty of Natural and Social Sciences, Heidelberg University of Education, Heidelberg, Germany. FAU - Hamrik, Zdenek AU - Hamrik Z AD - Faculty of Physical Culture, Palacky University Olomouc, Olomouc, Czech Republic. zdenek.hamrik@hbsc.org. LA - eng GR - IGA_FTK_2024_010/Internal Grant Agency of Palacky University Olomouc/ GR - IGA_FTK_2025_015/Internal Grant Agency of Palacky University Olomouc/ PT - Journal Article DEP - 20251218 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - Reproducibility of Results MH - Child MH - *Screen Time MH - Surveys and Questionnaires/standards MH - Mexico MH - Czech Republic MH - *Adolescent Behavior MH - Video Games/statistics & numerical data PMC - PMC12829222 OTO - NOTNLM OT - Children OT - HBSC OT - Psychometrics OT - Questionnaire reliability OT - Screen time COIS- Declarations. Ethics approval and consent to participate: The Mexican study was reviewed and approved by the Ethics Committee at the National Institute of Public Health. In Czechia the study was approved by Ethics Committee of the Faculty of Physical Culture Palacky University in Olomouc (11/2022- high school cohort; 57/2024-primary school cohort). Participation in the study was anonymous and voluntary, and no incentives were offered. Informed consent to participate was obtained from all study participants. For any participants under the age of 16, informed consent was obtained from their parents or legal guardians. In Mexico, the main objectives and procedures of the study were explained to parents, and informed consent was obtained from parents alongside assent from adolescents before data collection. In the Czech Republic, adolescents aged 16 years and older provided their own informed consent. For participants younger than 16 years, informed consent was obtained from parents or legal guardians, either directly for this survey or via the school's general informed consent procedure signed at the beginning of the school year, on the basis of which school principals confirmed participation. Prior to data collection, adolescents were informed that participation was voluntary and that they could skip any questions or withdraw at any time without consequences. All procedures were carried out in accordance with the ethical standards of the institutional research committees and with the 1964 Helsinki Declaration and its later amendments. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/19 01:45 MHDA- 2026/01/24 09:38 PMCR- 2025/12/18 CRDT- 2025/12/18 23:49 PHST- 2025/08/22 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/01/24 09:38 [medline] PHST- 2025/12/19 01:45 [pubmed] PHST- 2025/12/18 23:49 [entrez] PHST- 2025/12/18 00:00 [pmc-release] AID - 10.1186/s12889-025-25950-9 [pii] AID - 25950 [pii] AID - 10.1186/s12889-025-25950-9 [doi] PST - epublish SO - BMC Public Health. 2025 Dec 18;26(1):290. doi: 10.1186/s12889-025-25950-9. PMID- 41413090 OWN - NLM STAT- MEDLINE DCOM- 20251218 LR - 20260612 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Dec 18 TI - Detection of cortical arousals in sleep using multimodal wearable sensors and machine learning. PG - 44089 LID - 10.1038/s41598-025-27739-7 [doi] LID - 44089 AB - Cortical arousals are brief brain activations that disrupt sleep continuity and contribute to cardiovascular, cognitive, and behavioral impairments. Although polysomnography is the gold standard for arousal detection, its cost and complexity limit use in long-term or home-based monitoring. This study presents a noninvasive, machine learning-based framework for detecting cortical arousals using the RestEaze system, a leg-worn wearable that records multimodal physiological signals including accelerometry, gyroscope, photoplethysmography (PPG), and temperature. Across multiple methods tested, including logistic regression, XGBoost, and Random Forest classifiers, we found that features related to movement intensity were the most effective in identifying cortical arousals, while heart rate variability had a comparatively lower impact. The framework was evaluated in 14 children with attention-deficit/hyperactivity disorder (ADHD) undergoing assessment for restless leg syndrome-related sleep disruption. The Random Forest model achieved the best overall performance, with a ROC-AUC of 0.94 and an AUPRC of 0.55, substantially higher than the baseline prevalence of arousals (~ 0.07). For the arousal class specifically, it reached a precision of 0.57, recall of 0.78, and F1-score of 0.65. These findings support the feasibility of wearable-based machine learning for real-world arousal detection, demonstrated here in a pediatric ADHD cohort with sleep-related behavioral concerns. CI - (c) 2025. The Author(s). FAU - Kucukosmanoglu, Murat AU - Kucukosmanoglu M AD - D-Prime LLC, McLean, VA, 22101, USA. murat.kucukosmanoglu@dprime.ai. FAU - Conklin, Sarah AU - Conklin S AD - D-Prime LLC, McLean, VA, 22101, USA. AD - Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, Baltimore County, Baltimore, MD, 21250, USA. AD - Tanzen Medical Inc, Severna Park, MD, 21146, USA. FAU - Bansal, Kanika AU - Bansal K AD - Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, Baltimore County, Baltimore, MD, 21250, USA. AD - Humans in Complex Systems, Army DEVCOM Army Research Laboratory, Aberdeen Proving Ground, Aberdeen, 21005, MD, USA. FAU - Kaya, Sena AU - Kaya S AD - Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, Baltimore County, Baltimore, MD, 21250, USA. FAU - Anwar, Yumna AU - Anwar Y AD - Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, Baltimore County, Baltimore, MD, 21250, USA. FAU - Dang, Quang AU - Dang Q AD - Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, Baltimore County, Baltimore, MD, 21250, USA. FAU - Kargosha, Golshan AU - Kargosha G AD - D-Prime LLC, McLean, VA, 22101, USA. AD - Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, Baltimore County, Baltimore, MD, 21250, USA. FAU - Brooks, Justin AU - Brooks J AD - D-Prime LLC, McLean, VA, 22101, USA. AD - Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, Baltimore County, Baltimore, MD, 21250, USA. AD - Tanzen Medical Inc, Severna Park, MD, 21146, USA. FAU - Feltch, Cody AU - Feltch C AD - Tanzen Medical Inc, Severna Park, MD, 21146, USA. FAU - Banerjee, Nilanjan AU - Banerjee N AD - Department of Computer Science and Electrical Engineering, University of Maryland, Baltimore County, Baltimore County, Baltimore, MD, 21250, USA. AD - Tanzen Medical Inc, Severna Park, MD, 21146, USA. LA - eng GR - R43 MH133495/MH/NIMH NIH HHS/United States GR - 1R43MH133495-01A1/NH/NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20251218 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM UOF - Res Sq. 2025 May 16:rs.3.rs-6574148. doi: 10.21203/rs.3.rs-6574148/v1. PMID: 40470241 MH - Humans MH - *Machine Learning MH - Male MH - Female MH - *Wearable Electronic Devices MH - Child MH - *Arousal/physiology MH - *Sleep/physiology MH - Polysomnography/methods MH - Attention Deficit Disorder with Hyperactivity/physiopathology MH - Photoplethysmography MH - Accelerometry MH - Adolescent MH - Restless Legs Syndrome/physiopathology/diagnosis MH - Heart Rate/physiology PMC - PMC12715250 OTO - NOTNLM OT - ADHD OT - Cortical arousals OT - Machine learning OT - RestEaze OT - Sleep monitoring OT - Wearables COIS- Declarations. Competing interests: JB, CF, and NB are shareholders of Tanzen Medical Inc., the company that developed the RestEaze device evaluated in this study. All other authors declare no competing interests. EDAT- 2025/12/19 01:45 MHDA- 2025/12/19 01:46 PMCR- 2025/12/18 CRDT- 2025/12/18 23:27 PHST- 2025/05/01 00:00 [received] PHST- 2025/11/05 00:00 [accepted] PHST- 2025/12/19 01:46 [medline] PHST- 2025/12/19 01:45 [pubmed] PHST- 2025/12/18 23:27 [entrez] PHST- 2025/12/18 00:00 [pmc-release] AID - 10.1038/s41598-025-27739-7 [pii] AID - 27739 [pii] AID - 10.1038/s41598-025-27739-7 [doi] PST - epublish SO - Sci Rep. 2025 Dec 18;15(1):44089. doi: 10.1038/s41598-025-27739-7. PMID- 41411648 OWN - NLM STAT- MEDLINE DCOM- 20251218 LR - 20260926 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 14 DP - 2025 Dec 18 TI - Community-Based Adaptation and Evaluation of a Peer-Led Intervention to Address Alcohol Use and HIV in Pregnant and Breastfeeding Women in South Africa: Protocol for the "Mentor Mothers Plus" Randomized Control Trial. PG - e78856 LID - 10.2196/78856 [doi] LID - e78856 AB - BACKGROUND: In South Africa, pregnant and lactating women (PLW) face a dual burden of high alcohol use and HIV prevalence, both of which adversely affect maternal and infant health. However, few interventions address alcohol use and HIV risk concurrently in this population. OBJECTIVE: This study seeks to adapt and pilot-test in a randomized controlled trial (RCT) the peer-led multisession intervention Mentor Mothers Plus (MM+) to integrate alcohol reduction strategies with HIV prevention and care support (in a seroneutral intervention) among PLW in Saldanha Bay, Western Cape, South Africa. METHODS: Using the ADAPT-ITT (assessment, decision, adaptation, production, topical experts, integration, training, testing) framework, we adapted the evidence-based Mentor Mother (MM) model, originally aimed at reducing vertical HIV transmission among mothers with HIV. Our mixed methods design includes (1) qualitative research, including in-depth interviews (IDIs) and focus group discussions (FGDs), to assess drivers of perinatal alcohol use and HIV risk; (2) intervention adaptation through community-based participatory workshops with stakeholders to refine the MM+ intervention in order to include culturally and contextually strategies; and (3) a pilot RCT with 100 pregnant women (>/=16 years old, reporting recent alcohol use) randomized in a 1:1 ratio to the MM+ intervention (motivational interviewing [MI], including HIV and alcohol reduction messaging) or enhanced standard of care (SOC). Primary RCT outcomes include reduced alcohol use, via phosphatidylethanol (PEth) blood levels at 6-month follow-up. Secondary outcomes include uptake and adherence to pre-exposure prophylaxis (PrEP) and antiretroviral therapy (ART) among women with HIV, as well as intervention fidelity, feasibility, and acceptability. RESULTS: Community research included 2 FGDs with health workers (n=6) and community leaders (n=7) and 31 interviews with partners and peers of PLW. Data showed that women are motivated to reduce alcohol use for child health but face barriers (eg, misconceptions about safety of alcohol use, poverty, trauma, and intimate partner violence [IPV]). Alcohol use is with friends/family members/partners and tied to financial stress, unplanned pregnancy, and poor mental health. MM+ support preferences emphasize nonjudgmental, peer-based mentorship, family involvement, and faith/community engagement. Gaps include stigma around HIV and contraceptive services. Communities recommend mentor mothers with lived experience, providing culturally relevant, empathetic support, and linking to social and clinical services. In August 2025, a community workshop refined the intervention, emphasizing the need for trustworthy mentor mothers with lived experience. Priorities included culturally relevant information on alcohol use, HIV prevention, family planning, trauma and interpersonal violence support, and flexible delivery. Next steps involve finalizing materials, training mentor mothers, and launching the RCT. CONCLUSIONS: Our community-based, participatory study, MM+, offers a promising approach to address co-occurring alcohol use and HIV among PLW. Stakeholder engagement enhances contextual relevance and supports future scalability. The RCT will evaluate efficacy of the model in reducing alcohol and improving HIV outcomes. TRIAL REGISTRATION: Clinicaltrials.gov NCT06962592; https://clinicaltrials.gov/study/NCT06962592. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/78856. CI - (c)Zaynab Essack, Zaino Petersen, Amanda P Miller, Sarah Schoetz Dean, Danielle Daniels, Hayley Hofmeester, Thomas Belin, Heidi van Rooyen, Jaco Louw, Dvora Joseph Davey. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 18.12.2025. FAU - Essack, Zaynab AU - Essack Z AUID- ORCID: 0000-0002-8867-3415 AD - Human Sciences Research Council, Pretoria, South Africa. AD - University of KwaZulu-Natal, Pietermaritzburg, South Africa. FAU - Petersen, Zaino AU - Petersen Z AUID- ORCID: 0000-0002-6850-987X AD - Human Sciences Research Council, Pretoria, South Africa. FAU - Miller, Amanda P AU - Miller AP AUID- ORCID: 0000-0002-6462-1039 AD - Department of Epidemiology and Biostatistics, School of Public Health, San Diego State University, San Diego, United States. FAU - Schoetz Dean, Sarah AU - Schoetz Dean S AUID- ORCID: 0009-0002-3993-1526 AD - Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, United States. FAU - Daniels, Danielle AU - Daniels D AUID- ORCID: 0009-0001-2135-1454 AD - Human Sciences Research Council, Pretoria, South Africa. FAU - Hofmeester, Hayley AU - Hofmeester H AUID- ORCID: 0009-0007-8117-4756 AD - Foundation for Alcohol Related Research, Cape Town, South Africa. FAU - Belin, Thomas AU - Belin T AUID- ORCID: 0000-0003-4283-2676 AD - Department of Biostatistics, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, United States. FAU - van Rooyen, Heidi AU - van Rooyen H AUID- ORCID: 0000-0002-6502-6098 AD - Department of Global Health, School of Public Health, University of Washington, Seattle, WA, United States. FAU - Louw, Jaco AU - Louw J AUID- ORCID: 0000-0001-7812-2524 AD - Foundation for Alcohol Related Research, Cape Town, South Africa. FAU - Joseph Davey, Dvora AU - Joseph Davey D AUID- ORCID: 0000-0001-6290-9293 AD - Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, Los Angeles, CA, United States. AD - Division of Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States. LA - eng SI - ClinicalTrials.gov/NCT06962592 GR - K01 AA031208/AA/NIAAA NIH HHS/United States GR - R34 AA030942/AA/NIAAA NIH HHS/United States PT - Clinical Trial Protocol PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20251218 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Humans MH - Female MH - *HIV Infections/prevention & control/epidemiology MH - Pregnancy MH - South Africa/epidemiology MH - *Alcohol Drinking/prevention & control MH - Peer Group MH - *Breast Feeding MH - *Mentors MH - Infectious Disease Transmission, Vertical/prevention & control MH - Adult MH - Mothers/psychology MH - Randomized Controlled Trials as Topic MH - Pregnant People/psychology MH - Qualitative Research MH - Community-Based Participatory Research MH - Pilot Projects PMC - PMC12757709 OTO - NOTNLM OT - HIV OT - alcohol OT - community-based approach OT - peer-led intervention OT - pregnant and lactating women COIS- Conflicts of Interest: DJD has received funding for research from ViiV, Gilead, and Merck. APM has received two investigator studies awards from Merck/Sanofi Pasteur (MSP). All other coauthors have no conflicts to report. EDAT- 2025/12/18 19:24 MHDA- 2025/12/18 19:25 PMCR- 2025/12/18 CRDT- 2025/12/18 16:53 PHST- 2025/06/10 00:00 [received] PHST- 2025/09/30 00:00 [accepted] PHST- 2025/09/24 00:00 [revised] PHST- 2025/12/18 19:25 [medline] PHST- 2025/12/18 19:24 [pubmed] PHST- 2025/12/18 16:53 [entrez] PHST- 2025/12/18 00:00 [pmc-release] AID - v14i1e78856 [pii] AID - 10.2196/78856 [doi] PST - epublish SO - JMIR Res Protoc. 2025 Dec 18;14:e78856. doi: 10.2196/78856. PMID- 41410487 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251218 LR - 20260926 IS - 2045-7022 (Print) IS - 2045-7022 (Electronic) IS - 2045-7022 (Linking) VI - 15 IP - 12 DP - 2025 Dec TI - Associations Between the Maternal Diet Index and Childhood Asthma: The NorthPop and Healthy Start Cohorts. PG - e70144 LID - 10.1002/clt2.70144 [doi] LID - e70144 AB - BACKGROUND: A novel maternal diet index (MDI), characterizing offspring asthma- and allergy-associated maternal intake during pregnancy was constructed and validated in Healthy Start, USA. This study aims to (1) externally validate the asthma findings from Healthy Start in the NorthPop Birth Cohort Study (NorthPop) in Sweden; and (2) characterize the diet and demographics of the two cohorts. METHODS: The MDI was computed as a weighted combination of seven components associated with offspring allergies and asthma, including vegetables and yogurt (associated with decreased odds) and cold cereals, fried potatoes, juice, red meat, and rice (associated with increased odds). Doctor diagnoses provided childhood asthma incidence and timing. Parametric Weibull time-to-event analysis evaluated associations between the MDI, dichotomized at the median (72.2) for Healthy Start, and offspring asthma. RESULTS: The NorthPop and Healthy Start mean MDI values differed significantly (p < 0.001) and in NorthPop, only 6.1% had MDI < 72.2. Data from 6446 mother-child dyads in NorthPop yielded a crude hazard ratio (HR) for asthma of 0.70 (95% confidence interval [CI] 0.50-0.98, p = 0.037) and a fully adjusted HR of 0.84 (0.55-1.29; p = 0.428) for MDI > 72.2 versus < 72.2 (n = 4655). The fully adjusted HR for 945 Healthy Start dyads was significant at HR 0.41 (0.29-0.57; p < 0.0001). CONCLUSIONS: Results show that in a population with different maternal dietary patterns and demographics compared to the source population, MDI > 72.2 was not an independent predictor of offspring asthma. Further proof of the utility and generalizability of the MDI needs to be tested in other populations. CI - (c) 2025 The Author(s). Clinical and Translational Allergy published by John Wiley & Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology. FAU - Boden, Stina AU - Boden S AUID- ORCID: 0000-0002-8958-975X AD - Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden. AD - Section of Allergy & Immunology, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado, USA. FAU - Venter, Carina AU - Venter C AUID- ORCID: 0000-0002-7473-5355 AD - Section of Allergy & Immunology, Department of Pediatrics, University of Colorado Denver School of Medicine, Aurora, Colorado, USA. AD - Children's Hospital Colorado, Aurora, Colorado, USA. FAU - Pickett-Nairne, Kaci AU - Pickett-Nairne K AUID- ORCID: 0009-0000-1451-0229 AD - Department of Pediatrics, University of Colorado School of Medicine, University of Colorado Denver, Aurora, Colorado, USA. FAU - Glueck, Deborah H AU - Glueck DH AUID- ORCID: 0000-0003-0047-8939 AD - Department of Pediatrics, University of Colorado School of Medicine, University of Colorado Denver, Aurora, Colorado, USA. FAU - Lundberg-Ulfsdotter, Richard AU - Lundberg-Ulfsdotter R AUID- ORCID: 0000-0003-0399-4189 AD - Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden. FAU - Domellof, Magnus AU - Domellof M AUID- ORCID: 0000-0002-0726-7029 AD - Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden. FAU - Dabelea, Dana AU - Dabelea D AUID- ORCID: 0000-0001-9514-8929 AD - Department of Pediatrics, University of Colorado School of Medicine, University of Colorado Denver, Aurora, Colorado, USA. AD - Lifecourse Epidemiology of Adiposity and Diabetes Center, University of Colorado Anschutz Medical Campus, University of Colorado Denver, Aurora, Colorado, USA. AD - Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, Colorado, USA. FAU - West, Christina E AU - West CE AUID- ORCID: 0000-0001-9599-2580 AD - Department of Clinical Sciences, Pediatrics, Umea University, Umea, Sweden. LA - eng GR - RV 840681/Vasterbotten County Council/ GR - UG3 OD023248/OD/NIH HHS/United States/NH/NIH HHS/United States GR - RV-960756/Vasterbotten County Council/ GR - JLL-993810/Unit of Research, Region Jamtland Harjedalen Foundation/ GR - Swedish Foundation for International Cooperation in Research and Higher Education/ GR - Vetenskapsradet/ GR - Forte government agency/ GR - R01 GM121081/GM/NIGMS NIH HHS/United States/NH/NIH HHS/United States GR - RV 832441/Vasterbotten County Council/ GR - R25GM111901-S1/NH/NIH HHS/United States GR - R25 GM111901/GM/NIGMS NIH HHS/United States GR - 2018-02642/Swedish Research Council/ GR - UH3 OD023248/OD/NIH HHS/United States/NH/NIH HHS/United States GR - JLL-993235/Unit of Research, Region Jamtland Harjedalen Foundation/ GR - Umea University's strategic research funds/ GR - R01 DK076648/DK/NIDDK NIH HHS/United States GR - 2018-40/the Ekhaga Foundation/ GR - R01 GM121081/GM/NIGMS NIH HHS/United States GR - UG3 OD023248/OD/NIH HHS/United States GR - R01 DK076648/DK/NIDDK NIH HHS/United States/NH/NIH HHS/United States GR - UH3 OD023248/OD/NIH HHS/United States GR - 2021-01367/Swedish Research Council/ GR - R25GM111901/NH/NIH HHS/United States GR - Henning och Johan Throne-Holst's foundation for the promotion of scientific research/ GR - 20180641/the Heart-Lung Foundation/ GR - Kempe Foundation/ PT - Journal Article PL - England TA - Clin Transl Allergy JT - Clinical and translational allergy JID - 101576043 PMC - PMC12713374 OTO - NOTNLM OT - MDI OT - asthma prevention OT - childhood allergic disease OT - maternal diet OT - nutrition COIS- Dr. Venter reports grants from Reckitt Benckiser Food Allergy Research and Education, National Peanut Board; personal fees from Reckitt Benckiser, Nestle Nutrition Institute, Danone, Abbott Nutrition, Else Nutrition, Before Brands and Owen outside the submitted work. Dr. West has received research funding from Thermo Fisher Scientific and Arla, which was directly paid to the institution, and speaker honoraria from Thermo Fisher Scientific, Aimmune Therapeutics, a Nestle Health Science company, and Nutricia outside the submitted work. The other authors declare no conflicts of interest. Dr. Domellof has received consultation honoraria or speaker fees Baxter Medical AB, Danone Nutricia, Elgan Pharma, Fresenius Kabi Deutschland GmbH, Intertek Health Sciences Inc. and Ipsen AB as well as a grant/research support from Arla Foods Ingredients. EDAT- 2025/12/18 13:07 MHDA- 2025/12/18 13:08 PMCR- 2025/12/18 CRDT- 2025/12/18 09:24 PHST- 2025/10/16 00:00 [revised] PHST- 2025/07/30 00:00 [received] PHST- 2025/12/02 00:00 [accepted] PHST- 2025/12/18 13:08 [medline] PHST- 2025/12/18 13:07 [pubmed] PHST- 2025/12/18 09:24 [entrez] PHST- 2025/12/18 00:00 [pmc-release] AID - CLT270144 [pii] AID - 10.1002/clt2.70144 [doi] PST - ppublish SO - Clin Transl Allergy. 2025 Dec;15(12):e70144. doi: 10.1002/clt2.70144. PMID- 41410110 OWN - NLM STAT- MEDLINE DCOM- 20251218 LR - 20260106 IS - 2300-9020 (Electronic) IS - 1644-387X (Linking) VI - 62 IP - 6 DP - 2025 Nov-Dec TI - Laser therapy for the management of oral mucositis: An umbrella review - official recommendations of the Polish Society for Laser Dentistry. PG - 1157-1175 LID - 10.17219/dmp/213958 [doi] AB - Oral mucositis (OM) is a common and debilitating side effect of cancer therapy that impairs nutrition, increases infection risk, and often disrupts oncologic treatment. Photobiomodulation therapy (PBMT) has emerged as an effective, non-invasive method for OM prevention and management.This umbrella review was conducted in accordance with the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) 2020 guidelines and the Joanna Briggs Institute (JBI) methodology. A comprehensive search of PubMed(R)/MEDLINE, Embase, Scopus, and Cochrane Library identified systematic reviews and meta-analyses on laser therapy for OM published through July 2025. The data extraction process centered on clinical outcomes, laser parameters and safety.Twenty-two reviews met the inclusion criteria. Photobiomodulation therapy significantly reduced the incidence of OM, disease severity, pain, and healing time across adult and pediatric populations. Preventive PBMT decreased the risk of severe OM (grade 3-4) by 40-80%, while therapeutic PBMT shortened ulcer duration by 4-7 days. The combination of PBMT and photodynamic therapy (PDT) enhanced mucosal healing and alleviated pain. Optimal outcomes were achieved when wavelengths of 630-670 nm (intraoral) and 780-850 nm (extraoral) were used, with fluences of 2-6 J/cm2. No serious adverse events were reported.Photobiomodulation therapy demonstrates strong efficacy and safety in the management of OM, improving quality of life and treatment continuity in oncology patients. The Polish Society for Laser Dentistry (PTSL) endorses PBMT as a standard supportive care modality, particularly in the context of hematopoietic stem cell transplantation (HSCT) and head and neck chemoradiation. Protocol adherence and parameter standardization are essential to ensure the reproducibility and clinical effectiveness of research findings. FAU - Grzech-Lesniak, Kinga AU - Grzech-Lesniak K AD - Laser Laboratory, Department of Integrated Dentistry, Faculty of Medicine and Dentistry, Wroclaw Medical University, Poland. FAU - Fiegler-Rudol, Jakub AU - Fiegler-Rudol J AD - Department of Periodontal and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland. FAU - Grzech-Lesniak, Zuzanna AU - Grzech-Lesniak Z AD - Department of Experimental Dentistry, Faculty of Medicine and Dentistry, Wroclaw Medical University, Poland. FAU - Matys, Jacek AU - Matys J AD - Department of Dental Surgery, Faculty of Medicine and Dentistry, Wroclaw Medical University, Poland. FAU - Marek, Grzegorz AU - Marek G AD - 2nd Clinical Department of General Surgery and Surgical Oncology, Wroclaw Medical University, Poland. FAU - Skaba, Dariusz AU - Skaba D AD - Department of Periodontal and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland. FAU - Pokrzywka, Bartlomiej AU - Pokrzywka B AD - University of the National Education Commission, Krakow, Poland. FAU - Bubala, Halina AU - Bubala H AD - Department of Pediatric Hematology and Oncology, Prof. Stanislaw Szyszko Independent Public Clinical Hospital No. 1, Medical University of Silesia, Katowice, Poland. FAU - Dowgierd, Krzysztof AU - Dowgierd K AD - Head and Neck Surgery Clinic for Children and Young Adults, Department of Clinical Pediatrics, University of Warmia and Mazury in Olsztyn, Poland. FAU - Szuta, Mariusz AU - Szuta M AD - Department of Oral Surgery, Dental Institute, Faculty of Medicine, Jagiellonian University Medical College, Krakow, Poland. FAU - Dominiak, Marzena AU - Dominiak M AD - Department of Dental Surgery, Faculty of Medicine and Dentistry, Wroclaw Medical University, Poland. FAU - Ussowicz, Marek AU - Ussowicz M AD - Clinical Department of Pediatric Bone Marrow Transplantation, Oncology and Haematology, Faculty of Medicine, Wroclaw Medical University, Poland. FAU - Wrobel, Tomasz AU - Wrobel T AD - Clinical Department of Hematology, Cell Therapies and Internal Diseases, Faculty of Medicine, Wroclaw Medical University, Poland. FAU - Wiench, Rafal AU - Wiench R AD - Department of Periodontal and Oral Mucosa Diseases, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, Katowice, Poland. LA - eng PT - Journal Article PT - Systematic Review PL - Poland TA - Dent Med Probl JT - Dental and medical problems JID - 101205669 SB - IM MH - Humans MH - *Stomatitis/radiotherapy/therapy/etiology MH - *Low-Level Light Therapy/methods MH - *Laser Therapy/methods MH - Poland OTO - NOTNLM OT - cancer therapy OT - head and neck cancer OT - hematopoietic stem cell transplantation OT - low-level laser therapy OT - photobiomodulation EDAT- 2025/12/18 07:19 MHDA- 2025/12/18 07:20 CRDT- 2025/12/18 05:34 PHST- 2025/08/12 00:00 [received] PHST- 2025/11/04 00:00 [accepted] PHST- 2025/12/18 07:20 [medline] PHST- 2025/12/18 07:19 [pubmed] PHST- 2025/12/18 05:34 [entrez] AID - 10.17219/dmp/213958 [doi] PST - ppublish SO - Dent Med Probl. 2025 Nov-Dec;62(6):1157-1175. doi: 10.17219/dmp/213958. PMID- 41410046 OWN - NLM STAT- MEDLINE DCOM- 20260305 LR - 20260813 IS - 1524-4539 (Electronic) IS - 0009-7322 (Print) IS - 0009-7322 (Linking) VI - 153 IP - 9 DP - 2026 Mar 3 TI - Bradycardia in Athletes: Prevalence, Mechanisms, and Risks. PG - 616-630 LID - 10.1161/CIRCULATIONAHA.125.076170 [doi] AB - BACKGROUND: Sinus bradycardia is a well-recognized physiological adaptation in endurance athletes, primarily attributed to sinus node remodeling or increased vagal modulation. Although genetic influences on resting heart rate (HR) have been observed, the genetic contribution to athletic bradycardia has not been elucidated. METHODS: We phenotyped current and former elite endurance athletes in the Pro@Heart cohort study using multimodal cardiac imaging, cardiopulmonary exercise testing, and Holter monitoring. Genetic susceptibility to bradycardia was assessed using a validated HR-associated polygenic risk score (HR-PRS), in which lower scores are associated with a lower HR, and compared with healthy nonathletic controls. Clinical and genetic features of bradycardic endurance athletes with minimum HR /=2 s were observed in 115 (25%) athletes, of whom 12 (3% of total) had pauses >/=3 s. Mobitz I second-degree atrioventricular block was observed in 15 (3% of total) athletes. BAs were younger and fitter and exhibited greater athletic cardiac remodeling than non-BAs. Mean HR-PRS was significantly lower in all athletes compared with ASPREE nonathletes (P<0.001) and in BAs compared with non-BAs (P=0.006). When the distribution of HR-PRS within our athletic cohort was considered, athletes with scores in the bottom quartile had a lower minimum HR (median HR, 41 [35-45] bpm versus 45 [40-49] bpm, P<0.001) and higher bradycardia burden (14 [2-37]% versus 2 [0%-25]%, P<0.001) than those with scores in the top quartile. After adjusting for age, sex, fitness, and indexed right atrial volume, HR-PRS was independently associated with lower minimum HR and increased the odds of resting bradycardia by 2-fold (odds ratio [OR], 2.2 [95% CI, 1.3-3.9]; P=0.004). Neither bradycardia nor pauses were associated with increased risk of adverse outcomes over 5.5 years. CONCLUSIONS: Resting bradycardia (HR /= 60 min of MVPA per day. Among those who did, 87% still spent >/= 75% of their wear time sedentary. A greater proportion of SB relative to PA was associated with female gender (B = 0.13; p = 0.042), higher age (B = 0.06; p < 0.001), and higher BMI (B = 0.01; p = 0.049). Compared to controls, patients spent more time in SB, less in light-intensity PA, and slightly more in vigorous PA (all p < 0.001). Group differences remained significant after adjustment and were consistent across weekdays and weekends. CONCLUSIONS: Young people with well-controlled JIA show a distinctly unbalanced movement behaviour composition compared to controls, marked by a predominance of sedentary behaviour-even among those meeting PA guidelines. This highlights the limitations of threshold-based definitions and underscores the importance of assessing full daily movement patterns. Promoting light-intensity PA may offer a feasible strategy to reduce sedentary time, particularly in girls, older adolescents, and individuals with higher BMI. TRIAL REGISTRATION: The study was registered in the German Clinical Trials Register (DRKS00022258). FAU - Milatz, Florian AU - Milatz F AD - Programme area Epidemiology and Health Services Research, German Rheumatology Research Center Berlin, a Leibniz-Institute, Berlin, Germany. florian.milatz@drfz.de. AD - Institute for Social Medicine, Epidemiology and Health Economics, Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt- Universitat zu Berlin, Berlin, Germany. florian.milatz@drfz.de. AD - Partner site Berlin, German Center for Child and Adolescent Health (DZKJ), Berlin, Germany. florian.milatz@drfz.de. FAU - Voigt, Lisa AU - Voigt L AD - IGES Institute, Berlin, Germany. FAU - Klotsche, Jens AU - Klotsche J AD - Programme area Epidemiology and Health Services Research, German Rheumatology Research Center Berlin, a Leibniz-Institute, Berlin, Germany. FAU - Tomczyk, Samuel AU - Tomczyk S AD - Institute of Medical Psychology and Medical Sociology, University of Rostock, Rostock, Germany. AD - Partner site Greifswald/Rostock, German Center for Child and Adolescent Health (DZKJ), Rostock, Germany. FAU - Kallinich, Tilmann AU - Kallinich T AD - Partner site Berlin, German Center for Child and Adolescent Health (DZKJ), Berlin, Germany. AD - Department of Paediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt- Universitat zu Berlin , Berlin, Germany. AD - Systems Rheumatology, German Rheumatology Research Center Berlin, a Leibniz-Institute, Berlin, Germany. FAU - Trauzeddel, Ralf AU - Trauzeddel R AD - Department of Paediatrics, Helios Klinikum Berlin-Buch, Berlin, Germany. FAU - Windschall, Daniel AU - Windschall D AD - Clinic of Paediatric and Adolescent Rheumatology, Northwest German Centre for Rheumatology, St. Josef-Stift Sendenhorst, Sendenhorst, Germany. AD - Medizinische Fakultat, Universitat Halle-Wittenberg, Halle, Germany. FAU - Hansmann, Sandra AU - Hansmann S AD - Department of Neuropediatrics Developmental Neurology and Social Paediatrics, University of Tuebingen, Tuebingen, Germany. FAU - Baumeister, Nadja AU - Baumeister N AD - Department Health and Sport Sciences, Technical University of Munich, Munich, Germany. FAU - Haas, Johannes-Peter AU - Haas JP AD - German Centre for Pediatric and Adolescent Rheumatology, Garmisch-Partenkirchen, Germany. FAU - Klaas, Moritz AU - Klaas M AD - Children's Hospital, Vivantes Klinikum Friedrichshain, Berlin, Germany. FAU - Girschick, Hermann AU - Girschick H AD - Children's Hospital, Vivantes Klinikum Friedrichshain, Berlin, Germany. FAU - Peitz-Kornbrust, Joachim AU - Peitz-Kornbrust J AD - Department of Pediatrics, Children's Hospital Sankt Augustin, Sankt Augustin, Germany. FAU - Bohm, Peter AU - Bohm P AD - Deutsche Rheuma-Liga e. V., Bonn, Germany. FAU - Wiegand, Julius AU - Wiegand J AD - Deutsche Rheuma-Liga e. V., Bonn, Germany. FAU - Willich, Stefan N AU - Willich SN AD - Institute for Social Medicine, Epidemiology and Health Economics, Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt- Universitat zu Berlin, Berlin, Germany. FAU - Burchartz, Alexander AU - Burchartz A AD - Institute for Sports and Sports Science, Karlsruhe Institute of Technology, Karlsruhe, Germany. FAU - Minden, Kirsten AU - Minden K AD - Programme area Epidemiology and Health Services Research, German Rheumatology Research Center Berlin, a Leibniz-Institute, Berlin, Germany. AD - Partner site Berlin, German Center for Child and Adolescent Health (DZKJ), Berlin, Germany. AD - Department of Paediatric Respiratory Medicine, Immunology and Critical Care Medicine, Charite - Universitatsmedizin Berlin, corporate member of Freie Universitat Berlin and Humboldt- Universitat zu Berlin , Berlin, Germany. LA - eng PT - Journal Article PT - Multicenter Study PT - Observational Study DEP - 20251217 PL - England TA - Arthritis Res Ther JT - Arthritis research & therapy JID - 101154438 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Young Adult MH - Accelerometry/methods/instrumentation MH - *Arthritis, Juvenile/physiopathology/psychology/diagnosis MH - *Exercise/physiology MH - *Sedentary Behavior PMC - PMC12822130 OTO - NOTNLM OT - Accelerometry OT - Children and adolescents OT - Compositional data analysis OT - Juvenile idiopathic arthritis OT - Movement behaviour OT - Physical activity OT - Sedentary behaviour COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki and the principles of Good Clinical Practice. The ActiMON study (IRB approval number: EA2/204/20) and the NPRD registry (IRB approval number: EA1/044/07) were approved by the ethics committee of Charite - Universitatsmedizin Berlin and the relevant regional ethics boards of all participating centers. Written informed consent was obtained from all participants and/or their legal guardians, depending on age and local legal requirements. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/18 07:20 MHDA- 2026/06/27 04:10 PMCR- 2025/12/17 CRDT- 2025/12/18 00:08 PHST- 2025/06/17 00:00 [received] PHST- 2025/12/08 00:00 [accepted] PHST- 2026/06/27 04:10 [medline] PHST- 2025/12/18 07:20 [pubmed] PHST- 2025/12/18 00:08 [entrez] PHST- 2025/12/17 00:00 [pmc-release] AID - 10.1186/s13075-025-03714-5 [pii] AID - 3714 [pii] AID - 10.1186/s13075-025-03714-5 [doi] PST - epublish SO - Arthritis Res Ther. 2025 Dec 17;28(1):14. doi: 10.1186/s13075-025-03714-5. PMID- 41408391 OWN - NLM STAT- MEDLINE DCOM- 20260106 LR - 20260108 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2025 Dec 17 TI - Multicomponent intervention increases nutrition knowledge scores in rural China. PG - 213 LID - 10.1038/s41598-025-32277-3 [doi] LID - 213 AB - Improving residents' nutrition knowledge (NK) is crucial for enhancing dietary health. However, rural areas in China face significant challenges in accessing effective nutrition education. This study aimed to design and evaluate the effectiveness and feasibility of a multicomponent nutrition education intervention strategy suitable for resource-limited rural areas. This study was conducted in five administrative villages in Chengdu, with a total population of approximately 20,000. Through focus group discussion, a multicomponent nutrition education intervention was designed and implemented over a four-week period. The intervention's effectiveness was assessed using two independent cross-sectional surveys (pre-intervention n = 275; post-intervention n = 280, adjusted to n = 275 for analysis to match the baseline). A validated questionnaire was used to evaluate changes in NK levels. The priority of strategies was ultimately determined based on coverage, feasibility, and cost. Six intervention channels were identified through focus group discussion. Post-intervention, the median NK score among villagers increased significantly from 60.0 to 70.0 (an increase of 10 points, p < 0.001). NK levels improved significantly across all demographic subgroups (p < 0.05), with subgroups having lower baseline NK levels (e.g., males, older adults, less-educated individuals, non-health/wellness workers and non-chronic disease patients) showing greater improvement, indicating a "catch-up effect" that reduces knowledge inequality. Based on effectiveness and feasibility assessments, the prioritized order of intervention strategies was: loudspeaker broadcasts > WeChat group videos > posters > leaflets > Child-Teaching-Family (CTF) program > prize quizzes. Multicomponent nutrition education interventions can effectively and equitably improve the NK of rural residents in China. The combination of "loudspeaker broadcasts + WeChat group videos" was confirmed as the core strategy, with its low-cost and wide-coverage characteristics being suitable for promotion in resource-limited areas. It is recommended to institutionalize such models by integrating them into primary public health services and clarifying the leading role of local governments in resource integration and sustainable promotion, thereby contributing to the goals of "Healthy China". CI - (c) 2026. The Author(s). FAU - He, Zhifan AU - He Z AD - Department of Nutrition and Food Safety, Chengdu Center for Disease Control and Prevention (Chengdu Institute of Health Supervision), No 4. Longxiang Road, Chengdu, China. 504574004@qq.com. FAU - Feng, Ming AU - Feng M AD - Department of Nutrition and Food Safety, Chengdu Center for Disease Control and Prevention (Chengdu Institute of Health Supervision), No 4. Longxiang Road, Chengdu, China. FAU - Li, Lu AU - Li L AD - Pengzhou Center for Disease Control and Prevention, Chengdu, China. FAU - Li, Jing AU - Li J AD - Department of Nutrition and Food Safety, Chengdu Center for Disease Control and Prevention (Chengdu Institute of Health Supervision), No 4. Longxiang Road, Chengdu, China. FAU - Li, Xiaohui AU - Li X AD - Department of Nutrition and Food Safety, Chengdu Center for Disease Control and Prevention (Chengdu Institute of Health Supervision), No 4. Longxiang Road, Chengdu, China. lxhqj1@163.com. LA - eng PT - Journal Article DEP - 20251217 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - China MH - Male MH - Female MH - *Rural Population MH - Adult MH - Middle Aged MH - *Health Knowledge, Attitudes, Practice MH - Cross-Sectional Studies MH - *Health Education/methods MH - Surveys and Questionnaires MH - Aged MH - Young Adult MH - Focus Groups MH - Adolescent PMC - PMC12769725 OTO - NOTNLM OT - Adults OT - China OT - Community-based interventions OT - Health education OT - Nutrition knowledge OT - Rural populations COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: This study has been reviewed and approved by the Ethics Review Committee of Chengdu Center for Disease Control and Prevention (Approval Number: 2024008). During the research process, we strictly adhered to the relevant ethical guidelines and regulations, ensuring the compliance and quality of the study. Informed consent was obtained from each participant, and their participation was voluntary and anonymous throughout the survey. Participants were also given the option to withdraw from the study at any stage. EDAT- 2025/12/18 01:31 MHDA- 2026/01/06 19:17 PMCR- 2025/12/17 CRDT- 2025/12/17 23:50 PHST- 2025/09/29 00:00 [received] PHST- 2025/12/09 00:00 [accepted] PHST- 2026/01/06 19:17 [medline] PHST- 2025/12/18 01:31 [pubmed] PHST- 2025/12/17 23:50 [entrez] PHST- 2025/12/17 00:00 [pmc-release] AID - 10.1038/s41598-025-32277-3 [pii] AID - 32277 [pii] AID - 10.1038/s41598-025-32277-3 [doi] PST - epublish SO - Sci Rep. 2025 Dec 17;16(1):213. doi: 10.1038/s41598-025-32277-3. PMID- 41408208 OWN - NLM STAT- MEDLINE DCOM- 20251217 LR - 20251221 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 25 IP - 1 DP - 2025 Dec 17 TI - General obesity index or central obesity indicators: which is a better predictor of body fat percentage in the first trimester? PG - 1313 LID - 10.1186/s12884-025-08362-w [doi] LID - 1313 AB - OBJECTIVE: To compare general and central obesity indicators in their association with body fat percentage (BFP) in early pregnancy. METHODS: A retrospective study was carried out involving 10,267 women with singleton pregnancy who completed their first prenatal examination and body composition assessment at a tertiary women and children's hospital between January 2020 and December 2021. Data extracted from the hospital information system included personal information, BFP, the general obesity indicator (BMI), and central obesity indicators such as waist circumference (WC), hip circumference (HC), waist-hip ratio (WHR), and waist-height ratio (WHTR). The associations between BFP and obesity indices were calculated by Pearson correlation. The predictive performance of the general obesity index and central obesity indicators for estimating BFP was evaluated by the receiver operating characteristic (ROC) curve and its area under the curve (AUC). RESULTS: WHTR, WC, BMI, HC, and WHR were significantly correlated with BFP (p < 0.001 for all) in early pregnancy. The AUC values of WHTR, WC, BMI, HC, and WHR for predicting BFP were 0.89, 0.86, 0.85, 0.82, and 0.81, respectively. The combined effects of BMI, WC, HC, WHR, and WHTR on BFP were the largest (AUC = 0.92). CONCLUSIONS: All anthropometric obesity indices in early pregnancy were related to BFP. The most accurate and cost-effective approach for estimating BFP in early pregnancy was the combined use of WHTR, WC, BMI, HC, and WHR. With limited time and measurement conditions, WHTR may be the optimal obesity indicator to estimate BFP, followed by WC and BMI. CI - (c) 2025. The Author(s). FAU - Xiong, Anqi AU - Xiong A AD - Department of Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. FAU - Luo, Shiqi AU - Luo S AD - Department of Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. AD - Department of Neonatology Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Wang, Yan AU - Wang Y AD - Department of Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. AD - Department of Reproductive Medicine Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Wang, Yonghong AU - Wang Y AD - Department of Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. AD - Department of Obstetrics and Gynecology Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Guo, Xiujing AU - Guo X AD - Department of Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. AD - Department of Obstetrics and Gynecology Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Li, Xinyuan AU - Li X AD - Department of Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, People's Republic of China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. AD - Department of Obstetrics and Gynecology Nursing, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, China. FAU - Luo, Biru AU - Luo B AD - Department of Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, People's Republic of China. hxnurs@163.com. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. hxnurs@163.com. FAU - Liao, Shujuan AU - Liao S AD - Department of Nursing, West China Second University Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, Sichuan, People's Republic of China. liao_shujuan@163.com. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China. liao_shujuan@163.com. LA - eng GR - 21H0955/Sichuan University/ GR - 2022NSFSC0660/the Science and Technology Department, Sichuan Province, China/ PT - Journal Article DEP - 20251217 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Retrospective Studies MH - *Pregnancy Trimester, First MH - Adult MH - Waist-Hip Ratio MH - Body Mass Index MH - *Obesity/diagnosis MH - Waist Circumference MH - *Obesity, Abdominal/diagnosis MH - ROC Curve MH - Waist-Height Ratio MH - *Pregnancy Complications/diagnosis MH - Predictive Value of Tests MH - *Adipose Tissue PMC - PMC12709693 OTO - NOTNLM OT - Anthropometry OT - Body composition OT - Body fat percentage OT - Early pregnancy COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Medical Ethics Committee of West China Second Hospital, Sichuan University. The data of this retrospective study are anonymous, and the informed consent was therefore waived by the Medical Ethics Committee of West China Second Hospital, Sichuan University. Consent for publication: Not applicable in the declarations section. Competing interests: The authors declare no competing interests. EDAT- 2025/12/18 01:31 MHDA- 2025/12/18 01:32 PMCR- 2025/12/17 CRDT- 2025/12/17 23:42 PHST- 2024/08/01 00:00 [received] PHST- 2025/10/11 00:00 [accepted] PHST- 2025/12/18 01:32 [medline] PHST- 2025/12/18 01:31 [pubmed] PHST- 2025/12/17 23:42 [entrez] PHST- 2025/12/17 00:00 [pmc-release] AID - 10.1186/s12884-025-08362-w [pii] AID - 8362 [pii] AID - 10.1186/s12884-025-08362-w [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2025 Dec 17;25(1):1313. doi: 10.1186/s12884-025-08362-w. PMID- 41408203 OWN - NLM STAT- MEDLINE DCOM- 20260122 LR - 20260123 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2025 Dec 17 TI - Pre-pregnancy body mass index range and prevalence of hypertensive disorders of pregnancy: the Japan environment and children's study. PG - 69 LID - 10.1186/s12884-025-08459-2 [doi] LID - 69 AB - BACKGROUND: No consensus has been established for the optimal pre-pregnancy body mass index (BMI) required to reduce the incidence of hypertensive disorders of pregnancy (HDP) in Japanese women. This study investigated the association between the pre-pregnancy BMI range and the prevalence of HDP. METHODS: Data from 96,796 women with singleton pregnancies at >/= 22 weeks of gestation from the Japan Environment and Children's Study (enrolled between 2011 and 2014)-a nationwide birth cohort study-were analyzed. The participants were categorized according to pre-pregnancy BMI, as follows: 30.00 kg/m(2). Odds ratios (ORs) for HDP were calculated using multivariable regression analysis in each group, with the pre-pregnancy BMI 20.01-21.00 kg/m(2) group as the reference group, adjusted for maternal characteristics, followed by the Bonferroni correction. Pre-pregnancy BMI cut-off value for predicting the incidence of HDP was calculated through a receiver operating characteristic (ROC) curve analysis. RESULTS: The median pre-pregnancy BMI was 20.52 kg/m(2) (interquartile range: 19.07‒22.48 kg/m(2)). Adjusted ORs for HDP and severe HDP increased significantly in women with pre-pregnancy BMI > 22.00 kg/m(2), and in those with pre-pregnancy BMI of 24.01-25.00 kg/m(2) and BMI > 26.00 kg/m(2), respectively. No changes were observed in those with pre-pregnancy BMI 99%. A similar trend was observed when the analysis was restricted to individuals of Japanese nationality only. CONCLUSIONS: Pre-pregnancy BMI > 22.00 kg/m(2) was associated with an increased prevalence of HDP compared with the pre-pregnancy BMI 20.01-21.00 kg/m(2). Due to the low AUC, we propose that the cut-off BMI values for predicting the incidence of HDP may be used as a supplementary data to identify high-risk populations. CI - (c) 2025. The Author(s). FAU - Murata, Tsuyoshi AU - Murata T AUID- ORCID: 0000-0001-9506-117X AD - Fukushima Regional Center for the Japan Environment and Children's Study, 1 Hikarigaoka, Fukushima, 960-1295, Japan. tuyoshim@fmu.ac.jp. AD - Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. tuyoshim@fmu.ac.jp. FAU - Imaizumi, Karin AU - Imaizumi K AD - Fukushima Regional Center for the Japan Environment and Children's Study, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Isogami, Hirotaka AU - Isogami H AD - Fukushima Regional Center for the Japan Environment and Children's Study, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Fukuda, Toma AU - Fukuda T AD - Fukushima Regional Center for the Japan Environment and Children's Study, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Kyozuka, Hyo AU - Kyozuka H AD - Fukushima Regional Center for the Japan Environment and Children's Study, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Yasuda, Shun AU - Yasuda S AD - Fukushima Regional Center for the Japan Environment and Children's Study, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Yamaguchi, Akiko AU - Yamaguchi A AD - Fukushima Regional Center for the Japan Environment and Children's Study, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Sato, Akiko AU - Sato A AD - Fukushima Regional Center for the Japan Environment and Children's Study, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Ogata, Yuka AU - Ogata Y AD - Fukushima Regional Center for the Japan Environment and Children's Study, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Shinoki, Kosei AU - Shinoki K AD - Fukushima Regional Center for the Japan Environment and Children's Study, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Hosoya, Mitsuaki AU - Hosoya M AD - Fukushima Regional Center for the Japan Environment and Children's Study, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Department of Perinatology and Pediatrics for Regional Medical Support, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Hashimoto, Koichi AU - Hashimoto K AD - Fukushima Regional Center for the Japan Environment and Children's Study, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Department of Pediatrics, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Nishigori, Hidekazu AU - Nishigori H AD - Fukushima Regional Center for the Japan Environment and Children's Study, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Fukushima Medical Center for Children and Women, Fukushima Medical University, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Yasumura, Seiji AU - Yasumura S AD - Fukushima Regional Center for the Japan Environment and Children's Study, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Department of Public Health, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. FAU - Fujimori, Keiya AU - Fujimori K AD - Fukushima Regional Center for the Japan Environment and Children's Study, 1 Hikarigaoka, Fukushima, 960-1295, Japan. AD - Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan. CN - Japan Environment and Children's Study (JECS) Group LA - eng PT - Journal Article DEP - 20251217 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Body Mass Index MH - Japan/epidemiology MH - *Hypertension, Pregnancy-Induced/epidemiology/etiology MH - Prevalence MH - Adult MH - Risk Factors MH - Cohort Studies PMC - PMC12821895 OTO - NOTNLM OT - Birth cohort study OT - Body mass index OT - Hypertensive disorders of pregnancy OT - Japanese cohort COIS- Declarations. Ethics approval and consent to participate: The JECS protocol was reviewed and approved by the Ministry of the Environment Institutional Review Board on Epidemiological Studies (No. 100910001) and the Ethics Committees of all participating institutions. The JECS was conducted in accordance with the tenets of the Helsinki Declaration and other national regulations and guidelines. Written informed consent was obtained from all participants. Consent for publication: Written informed consent was obtained from all participants. Competing interests: The authors declare no competing interests. FIR - Kamijima, Michihiro IR - Kamijima M FIR - Yamazaki, Shin IR - Yamazaki S FIR - Ohya, Yukihiro IR - Ohya Y FIR - Kishi, Reiko IR - Kishi R FIR - Yaegashi, Nobuo IR - Yaegashi N FIR - Mori, Chisato IR - Mori C FIR - Ito, Shuichi IR - Ito S FIR - Yamagata, Zentaro IR - Yamagata Z FIR - Inadera, Hidekuni IR - Inadera H FIR - Nakayama, Takeo IR - Nakayama T FIR - Iso, Hiroyasu IR - Iso H FIR - Shima, Masayuki IR - Shima M FIR - Nakamura, Hiroshige IR - Nakamura H FIR - Suganuma, Narufumi IR - Suganuma N FIR - Kusuhara, Koichi IR - Kusuhara K FIR - Katoh, Takahiko IR - Katoh T EDAT- 2025/12/18 01:31 MHDA- 2026/01/22 07:43 PMCR- 2025/12/17 CRDT- 2025/12/17 23:42 PHST- 2023/01/12 00:00 [received] PHST- 2025/10/31 00:00 [accepted] PHST- 2026/01/22 07:43 [medline] PHST- 2025/12/18 01:31 [pubmed] PHST- 2025/12/17 23:42 [entrez] PHST- 2025/12/17 00:00 [pmc-release] AID - 10.1186/s12884-025-08459-2 [pii] AID - 8459 [pii] AID - 10.1186/s12884-025-08459-2 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2025 Dec 17;26(1):69. doi: 10.1186/s12884-025-08459-2. PMID- 41407932 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260120 LR - 20260124 IS - 2730-664X (Electronic) IS - 2730-664X (Linking) VI - 6 IP - 1 DP - 2025 Dec 17 TI - A metabolomic signature of maternal BMI is associated with pregnancy complications across two independent pregnancy cohorts. PG - 38 LID - 10.1038/s43856-025-01289-5 [doi] LID - 38 AB - BACKGROUND: Maternal obesity is increasingly common and linked to pregnancy complications, likely driven by underlying metabolic perturbations. This study investigates the association between maternal pre-pregnancy body mass index (BMI) and pregnancy complications through blood metabolomics, aiming to identify specific metabolites mediating these associations. METHODS: Data from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) and Vitamin D Antenatal Asthma Reduction Trial (VDAART) cohorts were used, with untargeted blood metabolomics performed on blood samples taken during early-, mid-, and late gestation. Associations were assessed using multivariable logistic regression and mediation analyses to explore metabolite pathways linking maternal BMI with pregnancy complications. RESULTS: In the COPSAC2010 cohort, maternal pre-pregnancy BMI is associated with gestational diabetes (OR 1.90 [1.29-2.74], p = 6.75x10(-)(4)), caesarean section (OR 1.23 [1.03-1.47], p = 0.023), and birth induction (OR 1.42 [1.21-1.67], p = 2.86x10(-)(5)). A BMI-associated metabolite score is even more strongly associated with these complications and is independently associated with preeclampsia (OR 1.54 [1.04-2.26], p = 0.030). Validation in the VDAART cohort confirms the predictive value of the metabolite score for gestational diabetes (OR 2.10 [1.48-3.03], p = 4.97x10(-)(5)) and preeclampsia (OR 2.12 [1.32-3.47], p = 0.002), particularly in late gestation. Mediation analysis in COPSAC2010 identifies 16 metabolites as mediating the effect of BMI on gestational diabetes. A model based on this subset of metabolites significantly outperforms the full maternal BMI model in predicting outcomes during both early (p = 0.009) and late gestation (p = 0.016) in the VDAART cohort. CONCLUSIONS: These findings suggest that integrating metabolomic profiling into prenatal care could improve the prediction and management of adverse pregnancy outcomes. CI - (c) 2025. The Author(s). FAU - Horner, David AU - Horner D AUID- ORCID: 0000-0002-0200-4561 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. david.horner@dbac.dk. FAU - Vinding, Rebecca AU - Vinding R AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Wang, Tingting AU - Wang T AUID- ORCID: 0000-0002-9100-3447 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Ali, Mina AU - Ali M AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Lovric, Mario AU - Lovric M AUID- ORCID: 0000-0002-3541-9624 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Prince, Nicole AU - Prince N AUID- ORCID: 0000-0002-8506-1122 AD - Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Lasky-Su, Jessica AU - Lasky-Su J AD - Channing Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Bonnelykke, Klaus AU - Bonnelykke K AUID- ORCID: 0000-0003-2003-1018 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Stokholm, Jakob AU - Stokholm J AUID- ORCID: 0000-0003-4989-9769 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. AD - Section of Food Microbiology, Gut Health and Fermentation, Department of Food Science, University of Copenhagen, Copenhagen, Denmark. FAU - Chawes, Bo AU - Chawes B AUID- ORCID: 0000-0001-6846-6243 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. FAU - Rasmussen, Morten Arendt AU - Rasmussen MA AUID- ORCID: 0000-0001-7431-5206 AD - COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. AD - Section of Food Microbiology, Gut Health and Fermentation, Department of Food Science, University of Copenhagen, Copenhagen, Denmark. LA - eng GR - K01 HL153941/HL/NHLBI NIH HHS/United States GR - R01 HL155742/HL/NHLBI NIH HHS/United States GR - R01 HL141826/HL/NHLBI NIH HHS/United States GR - 946228/EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)/ GR - R269-2017-5/Lundbeckfonden (Lundbeck Foundation)/ GR - 0603-00280B/Strategiske Forskningsrad (Danish Council for Strategic Research)/ GR - R01HL123915, R01HL155742, R01HL141826 and K01HL153941;amp;#x200B;;amp;#x200B;/Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.)/ GR - R01 HL123915/HL/NHLBI NIH HHS/United States GR - NNF21OC0068517/Novo Nordisk Fonden (Novo Nordisk Foundation)/ GR - R16-A1694/Lundbeckfonden (Lundbeck Foundation)/ PT - Journal Article DEP - 20251217 PL - England TA - Commun Med (Lond) JT - Communications medicine JID - 9918250414506676 PMC - PMC12820178 OAB - Many women enter pregnancy with a higher body weight, which increases the risk of complications such as diabetes, preeclampsia, and delivery by caesarean section. We wanted to understand why these risks occur and whether changes in the body's metabolism could explain them. To investigate this, we studied blood samples from two large groups of pregnant women in Denmark and the United States. We measured hundreds of small molecules, known as metabolites, and looked at how they relate to body weight and pregnancy outcomes. We found that certain metabolites help explain the link between higher body weight and complications such as diabetes and preeclampsia. These results suggest that blood metabolite testing could one day improve pregnancy care by identifying women at higher risk early on. OABL- eng COIS- Competing interests: J.L.-S. is a scientific advisor for Precion Inc and a consultant to Tru Diagnostic, Inc. Remaining authors (D.H., R.V., T.W., M.A., M.L., N.P., J.L.S., K.B., J.S., B.C., and M.R.) declare no potential, perceived, or real conflict of interest regarding the content of this manuscript. The funding agencies did not have any role in the design and conduct of the study; collection, management, and interpretation of the data; or preparation, review, or approval of the manuscript. No pharmaceutical company was involved in the study. EDAT- 2025/12/18 01:31 MHDA- 2025/12/18 01:32 PMCR- 2025/12/17 CRDT- 2025/12/17 23:28 PHST- 2024/10/18 00:00 [received] PHST- 2025/11/27 00:00 [accepted] PHST- 2025/12/18 01:32 [medline] PHST- 2025/12/18 01:31 [pubmed] PHST- 2025/12/17 23:28 [entrez] PHST- 2025/12/17 00:00 [pmc-release] AID - 10.1038/s43856-025-01289-5 [pii] AID - 1289 [pii] AID - 10.1038/s43856-025-01289-5 [doi] PST - epublish SO - Commun Med (Lond). 2025 Dec 17;6(1):38. doi: 10.1038/s43856-025-01289-5. PMID- 41407887 OWN - NLM STAT- MEDLINE DCOM- 20261005 LR - 20261008 IS - 1530-0447 (Electronic) IS - 0031-3998 (Print) IS - 0031-3998 (Linking) VI - 100 IP - 2 DP - 2026 Jul TI - Cardiotoxicity in pediatric oncology: a systematic review and meta-analysis. PG - 666-673 LID - 10.1038/s41390-025-04601-0 [doi] AB - BACKGROUND: Anthracycline-induced cardiotoxicity is a major concern in childhood cancer survivors. Detecting subclinical cardiac dysfunction early is critical, but the accuracy of current diagnostic tools is uncertain. METHODS: We performed a systematic review and meta-analysis of studies evaluating the prognostic accuracy of echocardiography, serum biomarkers, microRNAs (miRNAs), and artificial intelligence (AI) models in predicting chemotherapy-induced cardiotoxicity in pediatric patients. Seventy-three studies were included in the qualitative synthesis, and ten in the meta-analysis. Quality was assessed using the QUAPAS tool (CRD42023485629). RESULTS: AI-based models showed the highest pooled predictive performance area under the curve (AUC)~0.80, despite significant heterogeneity (I(2) = 93%). Global longitudinal strain (GLS) had moderate accuracy (AUC~0.72). Cardiac biomarkers like troponin and N-terminal pro-B-type natriuretic peptide (NT-proBNP) showed variable sensitivity and specificity, largely influenced by timing and thresholds. Preliminary evidence on miRNAs was promising but lacked standardization. Additional methods (e.g., cardiac MRI, cardiopulmonary exercise testing (CPET)) were excluded from meta-analysis due to methodological variability. CONCLUSION: No single modality reliably detects early cardiotoxicity. Promising tools like AI models and miRNAs need further validation. A multimodal diagnostic strategy combining imaging, biomarkers, and clinical data may be the most effective approach. Standardized definitions and protocols are urgently needed. IMPACT: Early detection of chemotherapy-induced cardiotoxicity in children remains unresolved. Multimodal assessment is most effective because no single test is sufficiently reliable. There are critical methodological gaps and heterogeneity that impede standardization in pediatric cardio-oncology. AI and microRNAs are promising but still unvalidated tools. The findings guide future clinical monitoring strategies and support standardized multimodal diagnostic algorithms. CI - (c) 2025. The Author(s). FAU - Beke, Nora AU - Beke N AD - Centre for Translational Medicine, Semmelweis University, Budapest, Hungary. FAU - Jockers, Xenia AU - Jockers X AD - Centre for Translational Medicine, Semmelweis University, Budapest, Hungary. AD - Pediatric Center, Tuzolto Street Department, Semmelweis University, Budapest, Hungary. FAU - Hernadfoi, Mark AU - Hernadfoi M AD - Centre for Translational Medicine, Semmelweis University, Budapest, Hungary. AD - Bethesda Children's Hospital, Budapest, Hungary. FAU - Koi, Tamas AU - Koi T AD - Centre for Translational Medicine, Semmelweis University, Budapest, Hungary. AD - Department of Stochastics, Institute of Mathematics, Budapest University of Technology and Economics, Budapest, Hungary. FAU - Lakatos, Keve AU - Lakatos K AD - Centre for Translational Medicine, Semmelweis University, Budapest, Hungary. FAU - Parniczky, Andrea AU - Parniczky A AD - Centre for Translational Medicine, Semmelweis University, Budapest, Hungary. AD - Heim Pal National Pediatric Institute, Budapest, Hungary. AD - Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary. FAU - Hegyi, Peter AU - Hegyi P AD - Centre for Translational Medicine, Semmelweis University, Budapest, Hungary. AD - Institute for Translational Medicine, Medical School, University of Pecs, Pecs, Hungary. AD - Institute of Pancreatic Diseases, Semmelweis University, Budapest, Hungary. FAU - Garami, Miklos AU - Garami M AD - Centre for Translational Medicine, Semmelweis University, Budapest, Hungary. garami.miklos@semmelweis.hu. AD - Pediatric Center, Tuzolto Street Department, Semmelweis University, Budapest, Hungary. garami.miklos@semmelweis.hu. LA - eng PT - Journal Article PT - Meta-Analysis PT - Systematic Review DEP - 20251217 PL - United States TA - Pediatr Res JT - Pediatric research JID - 0100714 RN - 0 (MicroRNAs) RN - 0 (Biomarkers) RN - 0 (Anthracyclines) RN - 0 (Antineoplastic Agents) SB - IM MH - Humans MH - Child MH - *Cardiotoxicity/diagnosis MH - MicroRNAs/blood/metabolism MH - Biomarkers/blood MH - *Neoplasms/drug therapy MH - *Anthracyclines/adverse effects MH - Echocardiography MH - Artificial Intelligence MH - *Antineoplastic Agents/adverse effects MH - Pediatrics MH - Heart Diseases/chemically induced PMC - PMC13638469 COIS- Competing interests: The authors declare no competing interests. Declaration of generative AI and AI-assisted technologies in the writing process: In preparing this manuscript, the authors employed ChatGPT (OpenAI, version 4, 2024) to assist in improving the readability of the text. The content was subsequently reviewed and refined by the authors, who take full responsibility for the content of the publication. EDAT- 2025/12/18 01:31 MHDA- 2026/10/06 05:29 PMCR- 2025/12/17 CRDT- 2025/12/17 23:25 PHST- 2025/05/09 00:00 [received] PHST- 2025/10/25 00:00 [accepted] PHST- 2025/10/22 00:00 [revised] PHST- 2026/10/06 05:29 [medline] PHST- 2025/12/18 01:31 [pubmed] PHST- 2025/12/17 23:25 [entrez] PHST- 2025/12/17 00:00 [pmc-release] AID - 10.1038/s41390-025-04601-0 [pii] AID - 4601 [pii] AID - 10.1038/s41390-025-04601-0 [doi] PST - ppublish SO - Pediatr Res. 2026 Jul;100(2):666-673. doi: 10.1038/s41390-025-04601-0. Epub 2025 Dec 17. PMID- 41407847 OWN - NLM STAT- MEDLINE DCOM- 20260121 LR - 20260124 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2025 Dec 17 TI - ME-BYO index as a formative construct for healthy ageing: a cross-sectional PLS-SEM analysis. PG - 2766 LID - 10.1038/s41598-025-32665-9 [doi] LID - 2766 AB - Innovative health measures are essential for promoting "healthy aging." The "ME-BYO" index considers health to exist on a continuum scale rather than as a binary state. This investigation sought to validate the ME-BYO index as a formative construct, examining if its constituent domains appropriately reflect overall health status using empirical data from the Kanagawa Prospective "ME-BYO" Cohort Study. We analyzed cross-sectional baseline data from 4,218 participants (aged 18-95 years, mean age, 57.8; 55.5% female) in the ME-BYO cohort. The ME-BYO index was specified as a higher-order formative construct composed of body mass index; blood pressure construct (systolic blood pressure, hypertension history); the 5-item Geriatric Locomotive Function Scale (GLFS-5) for locomotor function; and the 6-item Kessler Psychological Distress Scale (K6) for mental health. Its association with subjective well-being, a composite outcome including quality of life and subjective happiness, was examined using structural equation modeling. The GLFS-5 (outer weight: 0.695, t = 35.47) and the K6 (0.617, t = 20.23) were the strongest indicators of the ME-BYO index. Higher scores on the ME-BYO index (showing worse health) had a strong negative relationship with the subjective well-being outcome (path coefficient: -0.676, t = 71.99), accounting for 45.7% of the variance (R(2)). The ME-BYO index is a structurally valid formative measure that combines indicators from locomotor, mental, and metabolic domains. Its significant capacity to reflect subjective well-being supports its practical application in health surveillance and as a tool for empowering individuals to manage their health proactively. CI - (c) 2025. The Author(s). FAU - Nakamura, Sho AU - Nakamura S AD - Graduate School of Health Innovation, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan. research@nakasho.org. AD - Center for Innovation Policy, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan. research@nakasho.org. AD - Cancer Prevention and Control Division, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, Japan. research@nakasho.org. AD - Department of Genetic Medicine, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan. research@nakasho.org. FAU - Watanabe, Kaname AU - Watanabe K AD - Center for Innovation Policy, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan. AD - Cancer Prevention and Control Division, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, Japan. AD - Department of Genetic Medicine, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan. FAU - Chei, Choy-Lye AU - Chei CL AD - Cancer Prevention and Control Division, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, Japan. AD - Department of Genetic Medicine, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan. FAU - Feng, Lei AU - Feng L AD - Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. AD - Centre for Healthy Longevity, National University Health System, Singapore, Singapore. AD - Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. FAU - Ye, Kaisy Xinhong AU - Ye KX AD - Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. AD - Centre for Healthy Longevity, National University Health System, Singapore, Singapore. AD - Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. FAU - Lim, Kai Xuan AU - Lim KX AD - Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. AD - Centre for Healthy Longevity, National University Health System, Singapore, Singapore. AD - Healthy Longevity Translational Research Program, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. FAU - Watanabe, Ryo AU - Watanabe R AD - Graduate School of Health Innovation, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan. AD - Center for Innovation Policy, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan. FAU - Chung, Ung-Il AU - Chung UI AD - Graduate School of Health Innovation, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan. AD - Center for Innovation Policy, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan. AD - Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan. FAU - Narimatsu, Hiroto AU - Narimatsu H AD - Graduate School of Health Innovation, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan. AD - Center for Innovation Policy, Kanagawa University of Human Services, Kawasaki, Kanagawa, Japan. AD - Cancer Prevention and Control Division, Kanagawa Cancer Center Research Institute, Yokohama, Kanagawa, Japan. AD - Department of Genetic Medicine, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan. LA - eng GR - 16H06277/Japan Society for the Promotion of Science/ GR - 22H04923/Japan Society for the Promotion of Science/ GR - 17015018/Japanese Ministry of Education, Culture, Sports, Science and Technology/ GR - 221S0001/Japanese Ministry of Education, Culture, Sports, Science and Technology/ PT - Journal Article DEP - 20251217 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - Aged MH - Middle Aged MH - Cross-Sectional Studies MH - Male MH - Adult MH - Aged, 80 and over MH - *Healthy Aging/physiology/psychology MH - Adolescent MH - Quality of Life MH - Young Adult MH - Health Status MH - Mental Health MH - Body Mass Index MH - Blood Pressure MH - Prospective Studies PMC - PMC12824396 OTO - NOTNLM OT - Cross-sectional studies OT - Healthy aging OT - Locomotion OT - Longevity OT - ME-BYO OT - Mental health OT - Quality of life OT - Structural equation modeling COIS- Declarations. Competing interests: The authors declare no competing interests. Ethical approval and consent to participate: The ME-BYO cohort and analyses performed in this study were approved by the Ethics Committee of Kanagawa Cancer Center (Yokohama, Japan; approval no. 28KEN-36), and written informed consent was obtained from all participants. EDAT- 2025/12/18 01:31 MHDA- 2026/01/22 01:09 PMCR- 2025/12/17 CRDT- 2025/12/17 23:25 PHST- 2025/09/30 00:00 [received] PHST- 2025/12/11 00:00 [accepted] PHST- 2026/01/22 01:09 [medline] PHST- 2025/12/18 01:31 [pubmed] PHST- 2025/12/17 23:25 [entrez] PHST- 2025/12/17 00:00 [pmc-release] AID - 10.1038/s41598-025-32665-9 [pii] AID - 32665 [pii] AID - 10.1038/s41598-025-32665-9 [doi] PST - epublish SO - Sci Rep. 2025 Dec 17;16(1):2766. doi: 10.1038/s41598-025-32665-9. PMID- 41406465 OWN - NLM STAT- MEDLINE DCOM- 20251217 LR - 20260722 IS - 1929-0748 (Electronic) IS - 1929-0748 (Linking) VI - 14 DP - 2025 Dec 17 TI - IMplementation of Physical Activity for Children and adolescents on Treatment (IMPACT) for Cancer Diagnoses in Alberta: Protocol for a Single-Arm, Mixed-Methods, Hybrid Effectiveness-Implementation Trial. PG - e59302 LID - 10.2196/59302 [doi] LID - e59302 AB - BACKGROUND: Physical activity (PA) is feasible, safe, beneficial, and recommended for pediatric patients with cancer. Nevertheless, PA levels remain low due to treatment-related effects (eg, fatigue, pain), isolation and immunosuppression, geographic and transportation barriers, and limited access to population-specific programming. Delivering PA by videoconference may address some of these barriers. Thus, IMplementation of Physical Activity for Children and adolescents on Treatment (IMPACT) was developed. IMPACT is an individualized, tailored PA intervention delivered by an exercise professional over videoconference and is being evaluated in a hybrid effectiveness-implementation trial. OBJECTIVE: The objectives of this trial include (1) assessing the effectiveness of IMPACT on participants' device-measured PA (primary effectiveness outcome) and secondary effectiveness outcomes, including participant- and caregiver-reported PA and participant- and caregiver-reported quality of life, symptoms, cognitive function, resource use, and participant physical fitness outcomes (ie, participants' aerobic endurance, lower body flexibility, shoulder flexion range of motion, balance, functional mobility); and (2) assessing the implementation of IMPACT and the trial through evaluating recruitment, indices of feasibility, delivery time, expertise, cost, fidelity of intervention delivery, and adverse events. METHODS: A single-arm, mixed-methods, type II hybrid effectiveness-implementation trial is being conducted, and the RE-AIM (reach, effectiveness, adoption, implementation, maintenance) framework is guiding evaluation. Pediatric patients with cancer and blood disorders diagnosed between 5 and 18 years of age are being recruited in Alberta. Following informed consent/assent and baseline assessments (ie, participants' device-measured PA, participant- and caregiver-reported outcomes, participant physical fitness outcomes), participants receive individualized, tailored PA sessions up to 3 times/week for 15-45 minutes/session over 12 weeks from an exercise professional via videoconference. Assessments are then completed postintervention (with the addition of a participant and caregiver interview) and at 6- and 12-month follow-ups. With respect to RE-AIM, reach covers referral and participation rates, participants' and caregivers' personal and medical information, and the proportion of participants from rural versus urban locations. Effectiveness includes participants' device-measured PA, participant- and caregiver-reported outcomes, and participant physical fitness outcomes. Adoption covers sources of referral. Implementation includes recruitment, feasibility, delivery time, expertise, cost, fidelity of intervention delivery, and adverse events. Maintenance includes participants' and caregivers' desire for ongoing access to PA, and participant- and caregiver-reported PA levels at 6- and 12-month follow-ups. Throughout the trial, quality improvement cycles occur every 6 months. RESULTS: Funding was obtained in April 2022. Participant recruitment began in March 2022 and will conclude in December 2025. Interim analyses and additional analyses of selected trial data have been conducted, and publications are forthcoming. Full trial results will be analyzed and published following trial cessation. CONCLUSIONS: This work will provide insights into the effects of, and factors influencing, the implementation of an individualized, tailored PA intervention delivered by videoconference. Findings may support continued exploration of videoconference delivery as a strategy to ensure that more pediatric patients can access and benefit from PA. TRIAL REGISTRATION: ClinicalTrials.gov NCT04956133; https://clinicaltrials.gov/ct2/show/NCT04956133. INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID): DERR1-10.2196/59302. CI - (c)Emma McLaughlin, S Nicole Culos-Reed, Carolina Chamorro-Vina, Beverly Wilson, Sara Fisher, Gregory MT Guilcher, Bridget Penney, Mira Penney, Laura Wich, Janine Wich, Amanda Wurz. Originally published in JMIR Research Protocols (https://www.researchprotocols.org), 17.12.2025. FAU - McLaughlin, Emma AU - McLaughlin E AUID- ORCID: 0000-0001-9154-0800 AD - Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada. FAU - Culos-Reed, S Nicole AU - Culos-Reed SN AUID- ORCID: 0000-0003-3896-7383 AD - Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada. AD - Department of Oncology, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada. AD - Department of Psychosocial Resources, Arthur JE Child Comprehensive Centre, Alberta Health Services, Calgary, AB, Canada. FAU - Chamorro-Vina, Carolina AU - Chamorro-Vina C AUID- ORCID: 0000-0002-7853-8455 AD - Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada. AD - Kids Cancer Care Foundation of Alberta, Calgary, AB, Canada. FAU - Wilson, Beverly AU - Wilson B AUID- ORCID: 0000-0003-0500-5313 AD - Department of Pediatrics, University of Alberta, Edmonton, AB, Canada. AD - Stollery Children's Hospital, Edmonton, AB, Canada. FAU - Fisher, Sara AU - Fisher S AUID- ORCID: 0009-0004-2450-2096 AD - Stollery Children's Hospital, Edmonton, AB, Canada. FAU - Guilcher, Gregory Mt AU - Guilcher GM AUID- ORCID: 0000-0001-9380-4347 AD - Hematology/Oncology/BMT Clinic, Alberta Children's Hospital, Calgary, AB, Canada. FAU - Penney, Bridget AU - Penney B AUID- ORCID: 0009-0006-3380-8366 AD - Participant Advisory Board, Calgary, AB, Canada. FAU - Penney, Mira AU - Penney M AD - Participant Advisory Board, Calgary, AB, Canada. FAU - Wich, Laura AU - Wich L AUID- ORCID: 0009-0006-9581-143X AD - Participant Advisory Board, Calgary, AB, Canada. FAU - Wich, Janine AU - Wich J AUID- ORCID: 0009-0007-2849-9754 AD - Participant Advisory Board, Calgary, AB, Canada. FAU - Wurz, Amanda AU - Wurz A AUID- ORCID: 0000-0002-7804-9811 AD - Faculty of Kinesiology, University of Calgary, Calgary, AB, Canada. AD - School of Kinesiology, University of the Fraser Valley, Chilliwack, BC, Canada. AD - Research Institute, BC Children's Hospital, Vancouver, BC, Canada. LA - eng SI - ClinicalTrials.gov/NCT04956133 PT - Clinical Trial Protocol PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251217 PL - Canada TA - JMIR Res Protoc JT - JMIR research protocols JID - 101599504 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - Alberta MH - *Exercise/physiology MH - *Exercise Therapy/methods MH - *Neoplasms/therapy/diagnosis MH - Quality of Life MH - Videoconferencing MH - Multicenter Studies as Topic MH - Clinical Trials as Topic PMC - PMC12756665 OTO - NOTNLM OT - exercise OT - internet-based OT - movement OT - neoplasms OT - online OT - pediatric oncology OT - remote COIS- Conflicts of Interest: EM, CCV, BW, SF, GMTG, MP, BP, JW, and LW declare that they have no competing interests. SNCR is a co-founder of Thrive Health Services Inc, which provides preliminary training (Cancer and Exercise) for the qualified exercise specialists and physical assessors involved. AW developed the pediatric cancer and exercise module that is available on Thrive Health. EDAT- 2025/12/17 19:11 MHDA- 2025/12/17 19:12 PMCR- 2025/12/17 CRDT- 2025/12/17 16:54 PHST- 2025/06/26 00:00 [received] PHST- 2025/11/24 00:00 [accepted] PHST- 2025/12/17 19:12 [medline] PHST- 2025/12/17 19:11 [pubmed] PHST- 2025/12/17 16:54 [entrez] PHST- 2025/12/17 00:00 [pmc-release] AID - v14i1e59302 [pii] AID - 10.2196/59302 [doi] PST - epublish SO - JMIR Res Protoc. 2025 Dec 17;14:e59302. doi: 10.2196/59302. PMID- 41406002 OWN - NLM STAT- MEDLINE DCOM- 20251217 LR - 20260925 IS - 1536-7290 (Electronic) IS - 1746-1391 (Print) IS - 1536-7290 (Linking) VI - 26 IP - 1 DP - 2026 Jan TI - Validation of the Modified Athlete Dietary Index (mADI) Against a 7-Day Food Record Assessing Food Consumption Among Irish Athletes. PG - e70110 LID - 10.1002/ejsc.70110 [doi] LID - e70110 AB - Nutrition is crucial for enhancing performance and overall health among athletes. However, detailed dietary assessments are often time-consuming, challenging to conduct accurately, and burdensome. Therefore, there is a need for a more time and cost-effective method for assessing dietary intake among Irish athletes. This study aimed to validate a modified Athlete Dietary Index (mADI) as a screening tool for use among Irish athletes. Eligible participants included team and individual sport athletes over the age of 18 years, currently competing in competitions. Participants completed the electronic mADI followed by a 7-day food record (7DFR) using Qualtrics and Nutritics software platforms. Misreporting was assessed using the Goldberg cut-off. Validity for each food group was evaluated based on weighted kappa, two-way mixed effects intraclass correlation coefficient (ICC), relative bias, and Bland-Altman graphs. Eighty athletes (28.74 +/- 9.77 years) completed the mADI and 7DFR. Poor validity was found for servings per day (% bias > 20%, ICC < 0.50). Only eggs showed good validity for servings per week (-1.7% bias, ICC = 0.55). Acceptable to good validity (% bias < 10.9%) was observed for days per week, with 54% of food groups demonstrating good validity. Weighted kappa indicated an acceptable level of agreement for 62% of the comparisons. Overall, ICC suggested poor reliability for all but three food groups (eggs 0.55; fish 0.52; plant-based protein 0.63). The mADI demonstrated limited validity in assessing diet quality among athletes but showed potential as a screening tool to evaluate habitual dietary intake patterns in large groups of Irish athletes. CI - (c) 2025 The Author(s). European Journal of Sport Science published by Wiley-VCH GmbH on behalf of European College of Sport Science. FAU - Cremona, Alexandra AU - Cremona A AUID- ORCID: 0000-0002-4996-1430 AD - Faculty of Education and Health Sciences, School of Allied Health, University of Limerick, Limerick, Ireland. AD - Irish Nutrition and Dietetics Institute, Dublin, Ireland. AD - Health Research Institute, University of Limerick, Limerick, Ireland. FAU - Heidarian, Hamid Miri AU - Heidarian HM AD - School of Food and Nutritional Sciences, University College Cork, Cork, Ireland. FAU - Spillane, Keela AU - Spillane K AD - Faculty of Education and Health Sciences, School of Allied Health, University of Limerick, Limerick, Ireland. AD - Irish Nutrition and Dietetics Institute, Dublin, Ireland. FAU - Coady, Brian AU - Coady B AD - Faculty of Education and Health Sciences, School of Allied Health, University of Limerick, Limerick, Ireland. AD - Irish Nutrition and Dietetics Institute, Dublin, Ireland. FAU - Capling, Louise AU - Capling L AD - Faculty of Medicine and Health, Sydney School of Health Sciences, The University of Sydney, Camperdown, Australia. LA - eng PT - Journal Article PT - Validation Study PL - Germany TA - Eur J Sport Sci JT - European journal of sport science JID - 101146739 SB - IM MH - Humans MH - *Diet Records MH - Ireland MH - Male MH - *Athletes MH - Adult MH - Female MH - Young Adult MH - *Diet MH - Reproducibility of Results MH - *Nutrition Assessment MH - Adolescent PMC - PMC12710794 OTO - NOTNLM OT - athlete nutrition OT - dietary assessment OT - food record composition OT - irish athletes OT - mADI validation COIS- The authors declare no conflicts of interest. EDAT- 2025/12/17 19:11 MHDA- 2025/12/17 19:12 PMCR- 2025/12/17 CRDT- 2025/12/17 12:42 PHST- 2025/08/28 00:00 [revised] PHST- 2024/09/03 00:00 [received] PHST- 2025/12/06 00:00 [accepted] PHST- 2025/12/17 19:12 [medline] PHST- 2025/12/17 19:11 [pubmed] PHST- 2025/12/17 12:42 [entrez] PHST- 2025/12/17 00:00 [pmc-release] AID - EJSC70110 [pii] AID - 10.1002/ejsc.70110 [doi] PST - ppublish SO - Eur J Sport Sci. 2026 Jan;26(1):e70110. doi: 10.1002/ejsc.70110. PMID- 41403482 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251217 LR - 20251219 IS - 2249-4863 (Print) IS - 2278-7135 (Electronic) IS - 2249-4863 (Linking) VI - 14 IP - 11 DP - 2025 Nov TI - Nutritional status of under-5 children in Bangalore city during the COVID-19 pandemic. PG - 4763-4769 LID - 10.4103/jfmpc.jfmpc_497_25 [doi] AB - BACKGROUND: COVID-19 pandemic and the resultant social isolation, declined vaccination, and lack of school enrolment have contributed to undernutrition among children. OBJECTIVES: To assess nutritional status and associated factors among children aged 1-5 years enrolled in urban Anganwadis in Austin Town area, Bangalore city, during the COVID-19 pandemic. METHODOLOGY: A random sample of 100 children aged 1-5 years enrolled in two Anganwadis located in Austin Town was chosen. Data were collected using a structured face-validated questionnaire and measuring anthropometry. Nutrition status was classified using WHO Child Growth Standards. RESULT: There were 43% females and 57% males. The majority were in the age group of 4-5 years (32%) and belonged to a nuclear family 47%. 76% had a birth weight of more than 2.5 kg, 80% of them were full term, and 92% were immunized for age. Pre-COVID-19, 26% of the families were in lower middle and lower classes, and this proportion increased to 46% during COVID-19. Moderate acute malnutrition was observed among 12% of the children, and severe acute malnutrition was observed among 4% of the children. The factor which was significantly associated with malnutrition was the child's diet history of 3 meals and 2 snacks per day (P value 0.02). CONCLUSION: The prevalence of severe acute malnutrition is 4%. Child's diet history of 3 meals and 2 snacks is a significant protective factor against malnutrition. Community-based intervention such as nutrition education should be provided at Anganwadis for prevention of childhood malnutrition. CI - Copyright: (c) 2025 Journal of Family Medicine and Primary Care. FAU - Miranda, Neha Harshita AU - Miranda NH AD - Department of Community Health, St. John's Medical College, Bengaluru, Karnataka, India. FAU - Fare, Nadeen AU - Fare N AD - Department of Community Health, St. John's Medical College, Bengaluru, Karnataka, India. FAU - Gnanaselvam, Nancy Angeline AU - Gnanaselvam NA AD - Department of Community Health, St. John's Medical College, Bengaluru, Karnataka, India. FAU - Johnson, Avita Rose AU - Johnson AR AD - Department of Community Health, St. John's Medical College, Bengaluru, Karnataka, India. FAU - Ramesh, Naveen AU - Ramesh N AD - Department of Community Health, St. John's Medical College, Bengaluru, Karnataka, India. FAU - Shetty, Anupama AU - Shetty A AD - Director, Biocon Foundation, Bengaluru, Karnataka, India. LA - eng PT - Journal Article DEP - 20251129 PL - India TA - J Family Med Prim Care JT - Journal of family medicine and primary care JID - 101610082 PMC - PMC12704956 OTO - NOTNLM OT - COVID-19 OT - Children OT - WHO growth charts OT - growth monitoring OT - malnutrition OT - moderate acute malnutrition OT - nutrition OT - severe acute malnutrition OT - stunting OT - wasting COIS- There are no conflicts of interest. EDAT- 2025/12/17 06:40 MHDA- 2025/12/17 06:41 PMCR- 2025/11/01 CRDT- 2025/12/17 04:34 PHST- 2025/03/24 00:00 [received] PHST- 2025/06/20 00:00 [revised] PHST- 2025/06/23 00:00 [accepted] PHST- 2025/12/17 06:41 [medline] PHST- 2025/12/17 06:40 [pubmed] PHST- 2025/12/17 04:34 [entrez] PHST- 2025/11/01 00:00 [pmc-release] AID - JFMPC-14-4763 [pii] AID - 10.4103/jfmpc.jfmpc_497_25 [doi] PST - ppublish SO - J Family Med Prim Care. 2025 Nov;14(11):4763-4769. doi: 10.4103/jfmpc.jfmpc_497_25. Epub 2025 Nov 29. PMID- 41402970 OWN - NLM STAT- MEDLINE DCOM- 20260209 LR - 20260211 IS - 1471-0528 (Electronic) IS - 1470-0328 (Print) IS - 1470-0328 (Linking) VI - 133 IP - 4 DP - 2026 Mar TI - Prediction of Adverse Perinatal Outcome in Monochorionic Twin Pregnancy Using Fetal Biometry and Doppler Data: A Multicentre Cohort Study. PG - 823-832 LID - 10.1111/1471-0528.70116 [doi] AB - OBJECTIVE: To assess whether combining estimated fetal weight (EFW) and fetal Doppler ultrasound parameters would provide information to optimize the timing of birth in monochorionic twin pregnancies and prevent adverse perinatal outcomes. STUDY DESIGN: Retrospective multicentre cohort study. SETTING: Three tertiary centres in the UK, Italy and Belgium. POPULATION: 624 monochorionic twin pregnancies managed between 2013 and 2023. METHODS: Univariable and multivariable analyses assessed the association between EFW and Doppler indices taken within 2 weeks of birth. MAIN OUTCOME MEASURES: Stillbirth at any gestation or iatrogenic preterm birth before 34 weeks for suspected fetal compromise. RESULTS: The primary outcome occurred in 143 (22.9%) pregnancies with 70 cases of early PTB for fetal reasons and 73 cases of at least one IUD. Significant associations between biometric and Doppler parameters and adverse perinatal outcomes were found. The best-performing prediction models incorporated EFW discordance and umbilical artery pulsatility index (UA PI) discordance, achieving an AUC of 0.85 (95% CI 0.78-0.91) and EFW discordance and absent or reverse end diastolic flow of UA PI with an AUC of 0.86 (95% CI 0.80-0.92). The model incorporating EFW and UA PI discordance could be applied to the largest proportion of pregnancies and outperformed the currently clinical sFGR classification in predicting adverse outcomes. CONCLUSION: A model incorporating intertwin EFW discordance and UA PI discordance outperforms the current clinical classification for prediction of adverse perinatal outcomes in monochorionic pregnancies. If confirmed by further external validation studies, these findings could contribute to building a tailored risk assessment in these pregnancies. CI - (c) 2025 The Author(s). BJOG: An International Journal of Obstetrics and Gynaecology published by John Wiley & Sons Ltd. FAU - Lopian, Miriam AU - Lopian M AD - Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK. FAU - Giorgione, Veronica AU - Giorgione V AUID- ORCID: 0000-0003-3991-9308 AD - Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK. FAU - Trapani, Mariarita AU - Trapani M AD - Department of Women and Child Health, Women Health Area, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. FAU - Brutto, Mariafrancesca AU - Brutto M AD - Department of Women and Child Health, Women Health Area, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. FAU - Ferrante, Maria Giulia AU - Ferrante MG AD - Department of Women and Child Health, Women Health Area, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. FAU - Bhide, Amar AU - Bhide A AUID- ORCID: 0000-0003-2393-7501 AD - Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK. AD - Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK. FAU - Jani, Jacques C AU - Jani JC AD - Department of Obstetrics and Gynecology, University Hospital Brugmann, Universite Libre de Bruxelles, Brussels, Belgium. FAU - Badr, Dominique A AU - Badr DA AD - Department of Obstetrics and Gynecology, University Hospital Brugmann, Universite Libre de Bruxelles, Brussels, Belgium. FAU - Ghi, Tullio AU - Ghi T AD - Department of Women and Child Health, Women Health Area, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. AD - Catholic University of the Sacred Heart, Rome, Italy. FAU - Bevilacqua, Elisa AU - Bevilacqua E AUID- ORCID: 0000-0002-9791-9552 AD - Department of Women and Child Health, Women Health Area, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. FAU - Thilaganathan, Basky AU - Thilaganathan B AUID- ORCID: 0000-0002-5531-4301 AD - Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK. AD - Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK. FAU - Familiari, Alessandra AU - Familiari A AUID- ORCID: 0000-0002-6353-9383 AD - Department of Women and Child Health, Women Health Area, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. AD - Catholic University of the Sacred Heart, Rome, Italy. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20251216 PL - England TA - BJOG JT - BJOG : an international journal of obstetrics and gynaecology JID - 100935741 SB - IM MH - Humans MH - Female MH - Pregnancy MH - Retrospective Studies MH - *Ultrasonography, Prenatal/methods MH - *Pregnancy, Twin/statistics & numerical data MH - Biometry MH - Adult MH - *Ultrasonography, Doppler MH - *Fetal Weight MH - Umbilical Arteries/diagnostic imaging MH - Pregnancy Outcome/epidemiology MH - Stillbirth/epidemiology MH - Infant, Newborn MH - *Premature Birth/epidemiology MH - *Twins, Monozygotic MH - United Kingdom/epidemiology MH - Predictive Value of Tests MH - Italy/epidemiology MH - Belgium/epidemiology PMC - PMC12884219 OTO - NOTNLM OT - Doppler OT - adverse perinatal outcome OT - estimated fetal weight OT - fetal weight discordance OT - monochorionic OT - selective fetal growth restriction OT - stillbirths OT - twin pregnancies COIS- The authors declare no conflicts of interest. EDAT- 2025/12/17 00:25 MHDA- 2026/02/09 06:30 PMCR- 2026/02/09 CRDT- 2025/12/16 23:47 PHST- 2025/11/05 00:00 [revised] PHST- 2025/04/21 00:00 [received] PHST- 2025/12/03 00:00 [accepted] PHST- 2026/02/09 06:30 [medline] PHST- 2025/12/17 00:25 [pubmed] PHST- 2025/12/16 23:47 [entrez] PHST- 2026/02/09 00:00 [pmc-release] AID - BJO70116 [pii] AID - 10.1111/1471-0528.70116 [doi] PST - ppublish SO - BJOG. 2026 Mar;133(4):823-832. doi: 10.1111/1471-0528.70116. Epub 2025 Dec 16. PMID- 41402953 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260121 LR - 20260123 IS - 2055-5784 (Print) IS - 2055-5784 (Electronic) IS - 2055-5784 (Linking) VI - 12 IP - 1 DP - 2025 Dec 16 TI - Feasibility of 'Muscle Movers': a teacher-delivered program to support children's participation in muscle-strengthening physical activity. PG - 11 LID - 10.1186/s40814-025-01751-0 [doi] LID - 11 AB - BACKGROUND: Muscle-strengthening activity (MSA) is beneficial for school-aged children, but most school-based MSA interventions have been delivered by external specialists or research staff, limiting scalability. We aimed to assess the feasibility of a teacher-delivered MSA intervention for children in advance of a future efficacy trial. METHODS: We conducted a single-group feasibility trial with two Stage 2 (i.e. grade 3-4) classes from one primary school in New South Wales, Australia. The 6-week Muscle Movers intervention included (i) enhanced PE lessons focused on foundational MSA skills (1 x 45 min/week), (ii) classroom energiser breaks (2 x 5 min/week), and (iii) active homework tasks (1 x 10 min/week). We assessed acceptability, implementation, adaptation, and practicality using survey and interview methods. We also assessed pre-post change in children's perceived strength, upper-body muscular endurance, and lower-body muscular power. Data were analysed in SPSS (V.25) using descriptive statistics and paired-samples t-tests, with Cohen's d as a measure of effect size. RESULTS: Two female teachers (31 and 59 years) and 30 students (mean [SD] = 9.8 [0.6] years; 40% female) were enrolled. Acceptability was high for teachers (mean [SD] = 5.0 [0.0] out of 5) and students (mean [SD] = 4.1 [1.0] out of 5). Teachers implemented all PE lessons and more than double the intended energiser breaks (mean [SD] = 5.5 [2.1] per week). Conversely, homework task assignment (mean [SD] = 5.0 [1.4]) and completion (mean [SD] = 2.5 [0.7]) were lower than intended. Teachers reported high confidence to deliver the program and viewed it as practical and adaptable. We found a moderate increase in children's push-up performance (mean [95%CI] = 2.2 repetitions [0.7 to 3.8]; d = 0.61), but no meaningful changes in perceived strength (mean [95%CI] = 0.1 units [- 0.1 to 0.4]; d = 0.22) or standing long jump (mean [95%CI] = - 1.4 cm [- 7.4 to 4.7]; d = - 0.09). CONCLUSIONS: Muscle Movers was feasible for classroom teachers to implement in a primary school setting. The observed improvement in students' upper-body muscular endurance should be confirmed using an appropriately powered randomised controlled trial. TRIAL REGISTRATION: Retrospectively registered with the Australian and New Zealand Clinical Trials Registry (ACTRN12625000703404). CI - (c) 2025. The Author(s). FAU - Smith, Jordan J AU - Smith JJ AUID- ORCID: 0000-0003-4640-8645 AD - Global Sport and Movement Collaborative, College of Human and Social Futures, University of Newcastle, Callaghan, NSW, Australia. jordan.smith@newcastle.edu.au. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. jordan.smith@newcastle.edu.au. FAU - Kennedy, Sarah G AU - Kennedy SG AD - Global Sport and Movement Collaborative, College of Human and Social Futures, University of Newcastle, Callaghan, NSW, Australia. AD - School of Health Sciences, Western Sydney University, Kingswood, NSW, Australia. FAU - Eather, Narelle AU - Eather N AD - Global Sport and Movement Collaborative, College of Human and Social Futures, University of Newcastle, Callaghan, NSW, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. FAU - Riley, Nicholas AU - Riley N AD - Global Sport and Movement Collaborative, College of Human and Social Futures, University of Newcastle, Callaghan, NSW, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. FAU - Lubans, David R AU - Lubans DR AD - Global Sport and Movement Collaborative, College of Human and Social Futures, University of Newcastle, Callaghan, NSW, Australia. AD - Hunter Medical Research Institute, New Lambton Heights, NSW, Australia. LA - eng PT - Journal Article DEP - 20251216 PL - England TA - Pilot Feasibility Stud JT - Pilot and feasibility studies JID - 101676536 PMC - PMC12822025 OTO - NOTNLM OT - Intervention OT - Physical education OT - Resistance training OT - Strength OT - Teacher COIS- Declarations. Ethics approval and consent to participate: Approval for the study was obtained from the Human Research Ethics Committee of the University of Newcastle (H-2022-0273) and the Catholic Schools Office of the Diocese of Maitland-Newcastle. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2025/12/17 00:25 MHDA- 2025/12/17 00:26 PMCR- 2025/12/16 CRDT- 2025/12/16 23:46 PHST- 2025/07/13 00:00 [received] PHST- 2025/11/30 00:00 [accepted] PHST- 2025/12/17 00:26 [medline] PHST- 2025/12/17 00:25 [pubmed] PHST- 2025/12/16 23:46 [entrez] PHST- 2025/12/16 00:00 [pmc-release] AID - 10.1186/s40814-025-01751-0 [pii] AID - 1751 [pii] AID - 10.1186/s40814-025-01751-0 [doi] PST - epublish SO - Pilot Feasibility Stud. 2025 Dec 16;12(1):11. doi: 10.1186/s40814-025-01751-0. PMID- 41402942 OWN - NLM STAT- MEDLINE DCOM- 20260121 LR - 20260123 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 27 IP - 1 DP - 2025 Dec 16 TI - Design and implementation of a theory of planned behavior-based nutrition education intervention for adolescent girls in rural Nepal: a school-based cluster-randomized controlled trial. PG - 55 LID - 10.1186/s13063-025-09375-8 [doi] LID - 55 AB - Adolescence is a pivotal period of physical, psychological, and cognitive development during which individuals are highly vulnerable to nutritional deficiency. Undernutrition, overweight/obesity, and anemia are prominent public health concerns in low- and middle-income countries, including Nepal. Anemia affects nearly one-quarter of individuals aged 10-24 years globally, with a disproportionately high burden in resource-constrained settings. This study primarily aims to evaluate the effectiveness of a theory-driven school-based nutrition education intervention in improving dietary behaviors, health literacy, and nutritional status among adolescent girls in rural Nepal. This two-arm randomized controlled trial (RCT) evaluated the effectiveness of the Nutrition Education Intervention for Promoting Health (NEIPH) program for improving the nutritional status of adolescent girls in rural Nepal. Adolescent girls (200) with low serum ferritin levels (40.7-75.7 ng/mL), enrolled in grades 7-9 across 19 public schools in Annapurna Rural Municipality, were randomly assigned to either an intervention (103 girls from nine schools) or a control (97 girls from 10 schools) group. The intervention group received two 60-min interactive education sessions over 1 month, school-based monitoring, and a standardized educational booklet. The sessions incorporated multimedia presentations, role-play activities, group discussions, and teach-back exercises to reinforce key concepts. The control group received booklets approved by the National Health Education, Information, and Communication Center. The educational content covered balanced nutrition, dietary sources, anemia prevention, adolescent health, and menstrual hygiene and was delivered using multimedia tools and participatory techniques. The NEIPH intervention is expected to be a viable approach for improving the nutritional status and reducing anemia by influencing the behaviors of adolescent girls. The combined use of the theory of planned behavior and the teach-back method represents a novel and structured approach to enhance comprehension, promote self-efficacy, and foster sustained behavioral change. The trial is currently ongoing, and no outcome data have been analyzed. This paper provides a detailed account of the theoretical framework, intervention development, and implementation procedures to promote methodological transparency and reproducibility. CI - (c) 2025. The Author(s). FAU - Bhandari, Tulsi Ram AU - Bhandari TR AD - Faculty of Health Science, School of Health and Allied Sciences, Pokhara University, Lekhnath, Nepal. FAU - Paudel, Shishir AU - Paudel S AUID- ORCID: 0000-0003-3077-6697 AD - Kathmandu Institute of Child Health, Hepali Height, Budhanilkantha, Kathmandu, Nepal. shishirpaudel11@gmail.com. FAU - Chapagain, Nawaraj AU - Chapagain N AD - Nutrition Research Project of Kansai Medical University, Japan, in Annapurna Rural Municipality, Kaski, Nepal. FAU - Thapa, Yoko Oda AU - Thapa YO AD - Nutrition Research Project of Kansai Medical University, Japan, in Annapurna Rural Municipality, Kaski, Nepal. FAU - Nagila, Amar AU - Nagila A AD - Faculty of Health Science, School of Health and Allied Sciences, Pokhara University, Lekhnath, Nepal. FAU - Kawata, Rina AU - Kawata R AD - Department of Nursing, Faculty of Human Care at Makuhari, Tohto University, Chiba, Japan. FAU - Iwakuni, Akiko AU - Iwakuni A AD - Faculty of Nursing, Kansai Medical University, Hirakata, Japan. FAU - Lee, Kumsun AU - Lee K AD - Faculty of Nursing, Graduate School of Nursing, Kansai Medical University, Hirakata, Japan. FAU - Hiroko, Sakai AU - Hiroko S AD - Faculty of Nursing, Graduate School of Nursing, Kansai Medical University, Hirakata, Japan. LA - eng GR - 22KK0026/Japan Society of the Promotion of Science (JSPS)/ PT - Clinical Trial Protocol PT - Journal Article DEP - 20251216 PL - England TA - Trials JT - Trials JID - 101263253 SB - IM MH - Humans MH - Adolescent MH - Female MH - Nepal MH - Nutritional Status MH - *Health Education/methods MH - Child MH - *Adolescent Behavior MH - Health Knowledge, Attitudes, Practice MH - *School Health Services MH - Health Literacy MH - *Diet, Healthy MH - *Health Behavior MH - Rural Population MH - *Adolescent Nutritional Physiological Phenomena MH - Young Adult MH - Randomized Controlled Trials as Topic MH - *Feeding Behavior MH - Theory of Planned Behavior PMC - PMC12821813 OTO - NOTNLM OT - Adolescents OT - Anemia OT - Intervention OT - Malnutrition OT - Preconception care OT - Randomized controlled trial OT - Theory of planned behavior COIS- Ethics approval and consent to participate: The research protocol was reviewed and approved by the Nepal Health Research Council (Proposal ID 704-2023, approved review date: January 23, 2024). Consent for publication: NA Competing interests: The authors declare that they have no competing interests. EDAT- 2025/12/17 00:25 MHDA- 2026/01/21 06:30 PMCR- 2025/12/16 CRDT- 2025/12/16 23:46 PHST- 2025/08/11 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/01/21 06:30 [medline] PHST- 2025/12/17 00:25 [pubmed] PHST- 2025/12/16 23:46 [entrez] PHST- 2025/12/16 00:00 [pmc-release] AID - 10.1186/s13063-025-09375-8 [pii] AID - 9375 [pii] AID - 10.1186/s13063-025-09375-8 [doi] PST - epublish SO - Trials. 2025 Dec 16;27(1):55. doi: 10.1186/s13063-025-09375-8. PMID- 41402912 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1824-7288 (Electronic) IS - 1720-8424 (Linking) VI - 52 IP - 1 DP - 2025 Dec 16 TI - The impact of nutritional and socioeconomic status on academic performance of primary urban school children in northern Ethiopia: a cross-sectional study. PG - 10 LID - 10.1186/s13052-025-02175-5 [doi] LID - 10 AB - BACKGROUND: Urban school children are challenged from varying degrees of poverty, access to resources and health services ultimately impacting their academic performance. Educational success is complex highlighting that several factors may contribute to its outcome. Among these, undernutrition and socioeconomic status significantly impact academic performance. The interplay between these determinants and educational outcomes is particularly significant in developing countries such as northern Ethiopia. Children from lower socioeconomic backgrounds often experience nutritional deficiencies that can adversely impact cognitive development leading for poor educational achievement. Thus, this research can fill existing gaps regarding the interaction between undernutrition and socioeconomic factors that enable to understand how they interact to affect children's educational outcomes. In addition, the study will provide practical implications for policymakers and educators in Ethiopia as it enables them for developing more effective educational policies that address unique challenges faced by urban school children in northern Ethiopia. Therefore, our study aimed to assess predictors of academic performance among primary school students to address the multifaceted issues and develop effective interventions. METHOD: This institution-based cross-sectional study was conducted in three of seven primary public schools. Simple random sampling technique were employed to select the schools and proportional allocation was done to each school to draw a total of 399 study participants. An interviewer administered questionnaire were used to gather socioeconomic data from the children's legal guardians. Academic performance was evaluated using the average scores from all subjects over two semesters obtained from school rosters. Nutritional status was assessed via anthropometric measurements with Height-for-Age (HAZ), Weight-for- Age (WAZ) and Body Mass Index-for-Age (BAZ) calculated according to the WHO 2007 standard reference guidelines. WHO Anthro version 3.2.2 was used for the analysis and interpretation of nutritional status. Data were entered, cleaned and validated using Epi Data version 3.1 and subsequently analyzed using SPSS version 24. A bivariate and multivariate logistic regression were done to determine candidate variables and significantly associated factors respectively. Variables with p-value of 15 years were recruited from the Nutrition and Health Survey data. Dietary patterns were discerned through principal component analysis (PCA) and reduced rank regression (RRR). Associations between dietary pattern scores, vitamin D, and anemia-related biomarkers were validated using linear and binomial logistic regression adjusted for sociodemographic and economic factors. Results: Two dietary patterns were identified: a plant and marine-based dietary pattern (PMDP) via PCA and a convenience food dietary pattern (CFDP) via RRR. PMDP was characterized by high intakes of plant and marine foods, while CFDP showed high intakes of canned and pickled foods. Risk estimation indicated that high PMDP intake was associated with 30% reduction in odds of vitamin D insufficiency, while moderate CFDP intake was linked to an increased risk of vitamin D insufficiency by 46%. Logistic regression analysis showed a positive association between CFDP and serum iron (beta = 0.08; 95% CI: 0.05, 0.24), but a negative association with total iron binding capacity (beta = -0.05; 95% CI: -0.44, -0.07). Conclusions: The PCA-derived dietary pattern effectively identifies eating patterns, while the RRR-derived dietary pattern has a better estimate for disease associations in a specific population. The RRR-derived dietary pattern provides valuable insights for dietary guidelines targeting vitamin D insufficiency. CI - (c) The author(s). FAU - Das, Arpita AU - Das A AD - School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan. FAU - Hsu, Chien-Yeh AU - Hsu CY AD - Department of Information Management, National Taipei University of Nursing and Health Sciences, Taipei, Taiwan. AD - Master Program in Global Health and Health Security, Taipei Medical University, Taipei, Taiwan. FAU - Bai, Chyi-Huey AU - Bai CH AD - Department of Public Health, School of Medicine, Taipei Medical University, Taipei, Taiwan. AD - School of Public Health, Taipei Medical University, Taipei, Taiwan. AD - Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan. FAU - Chang, Jung-Su AU - Chang JS AD - School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan. AD - Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan. AD - Graduate Institute of Metabolism and Obesity Sciences, Taipei Medical University, Taipei, Taiwan. AD - TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, Taiwan. FAU - Huang, Ya-Li AU - Huang YL AD - Department of Public Health, School of Medicine, Taipei Medical University, Taipei, Taiwan. AD - School of Public Health, Taipei Medical University, Taipei, Taiwan. FAU - Wang, Fan-Fen AU - Wang FF AD - Department of Internal Medicine, Yangming Branch, Taipei City Hospital, Taipei, Taiwan. FAU - Nguyen, Nhi Thi Hong AU - Nguyen NTH AD - School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan. AD - Health Personnel Training Institute, University of Medicine and Pharmacy, Hue University, Hue, Vietnam. FAU - Chen, Yi-Chun AU - Chen YC AD - School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan. FAU - Chao, Jane C-J AU - Chao JC AD - School of Nutrition and Health Sciences, Taipei Medical University, Taipei, Taiwan. AD - Master Program in Global Health and Health Security, Taipei Medical University, Taipei, Taiwan. AD - Nutrition Research Center, Taipei Medical University Hospital, Taipei, Taiwan. AD - TMU Research Center for Digestive Medicine, Taipei Medical University, Taipei, Taiwan. LA - eng PT - Comparative Study PT - Journal Article DEP - 20260101 PL - Australia TA - Int J Med Sci JT - International journal of medical sciences JID - 101213954 RN - 1406-16-2 (Vitamin D) SB - IM MH - Humans MH - Female MH - *Vitamin D Deficiency/epidemiology/blood/etiology MH - Adult MH - Cross-Sectional Studies MH - Pregnancy MH - Vitamin D/blood MH - *Diet/adverse effects MH - Nutrition Surveys MH - Young Adult MH - Principal Component Analysis MH - *Feeding Behavior MH - *Anemia/epidemiology/blood/etiology MH - Adolescent PMC - PMC12702124 OTO - NOTNLM OT - anemia-related biomarkers OT - principal component analysis OT - reduced rank regression analysis OT - serum vitamin D COIS- Competing Interests: The authors have declared that no competing interest exists. EDAT- 2025/12/16 06:29 MHDA- 2025/12/16 06:30 PMCR- 2026/01/01 CRDT- 2025/12/16 04:03 PHST- 2025/08/20 00:00 [received] PHST- 2025/11/21 00:00 [accepted] PHST- 2025/12/16 06:30 [medline] PHST- 2025/12/16 06:29 [pubmed] PHST- 2025/12/16 04:03 [entrez] PHST- 2026/01/01 00:00 [pmc-release] AID - ijmsv23p0325 [pii] AID - 10.7150/ijms.124006 [doi] PST - epublish SO - Int J Med Sci. 2026 Jan 1;23(1):325-333. doi: 10.7150/ijms.124006. eCollection 2026. PMID- 41399148 OWN - NLM STAT- MEDLINE DCOM- 20251216 LR - 20260925 IS - 1532-7078 (Electronic) IS - 1525-0008 (Print) IS - 1532-7078 (Linking) VI - 30 IP - 6 DP - 2025 Nov-Dec TI - Complementary Feeding Approach and Maternal Communicative Functions During Mealtimes in 12-Month-Old Infants. PG - e70060 LID - 10.1111/infa.70060 [doi] LID - e70060 AB - The literature on alternative approaches to complementary feeding, especially Baby-Led Weaning (a complementary feeding approach in which infants participate in family meals and eat finger food independently), has gradually increased in recent years. The present study aims to investigate whether there is a relation between the complementary feeding approach chosen by parents (Baby-Led Weaning or Parent-Led Weaning, in which infants are fed pureed food on a spoon) and maternal communicative functions produced during a typical meal. We analyzed the transcripts of mother-infant interactions occurring during mealtimes of 136 12-month-old typically developing infants, by means of a validated coding scheme that allows to identify five different communicative functions (Tutorial, Didactic, Conversational, Control and Asynchronous). The results highlighted a slightly different pattern of communicative style depending on the feeding method adopted by the parents (BLW vs. PLW). In particular, mothers of infants exposed to the PLW approach used the Tutorial function more often than mothers of infants exposed to the BLW method. The two groups did not differ in their use of the other functions. The implications for the promotion of healthy eating behaviors within family interactive contexts are discussed. CI - (c) 2025 The Author(s). Infancy published by Wiley Periodicals LLC on behalf of International Congress of Infant Studies. FAU - Di Prete, Alice AU - Di Prete A AUID- ORCID: 0009-0003-1069-5117 AD - Sapienza Universita di Roma, Rome, Italy. FAU - Ciolli, Mariarosaria AU - Ciolli M AD - Sapienza Universita di Roma, Rome, Italy. FAU - Iaboni, Elisa AU - Iaboni E AD - Sapienza Universita di Roma, Rome, Italy. FAU - Palladino, Noemi AU - Palladino N AD - Sapienza Universita di Roma, Rome, Italy. FAU - Pecora, Giulia AU - Pecora G AUID- ORCID: 0000-0001-7099-706X AD - Universita degli Studi di Roma "Tor Vergata", Rome, Italy. FAU - Paoletti, Melania AU - Paoletti M AD - Sapienza Universita di Roma, Rome, Italy. FAU - Focaroli, Valentina AU - Focaroli V AD - Universita degli Studi "Niccolo Cusano", Rome, Italy. FAU - Caravale, Barbara AU - Caravale B AD - Sapienza Universita di Roma, Rome, Italy. FAU - Gastaldi, Serena AU - Gastaldi S AD - Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy. FAU - Addessi, Elsa AU - Addessi E AD - Istituto di Scienze e Tecnologie della Cognizione, Rome, Italy. FAU - Bellagamba, Francesca AU - Bellagamba F AD - Sapienza Universita di Roma, Rome, Italy. FAU - Longobardi, Emiddia AU - Longobardi E AUID- ORCID: 0000-0002-0997-0623 AD - Sapienza Universita di Roma, Rome, Italy. LA - eng GR - CUP B53D23014810006/Funded by the European Union - Next Generation EU, Mission 4 Component 1/ GR - CUP B53D23014820006/Funded by the European Union - Next Generation EU, Mission 4 Component 1/ GR - PRIN 2022 grant number 2022S8PEY7/Funded by the European Union - Next Generation EU, Mission 4 Component 1/ GR - PRIN 2017 2017WH8B84/Italian Ministry of Education, University and Research, Progetti di Rilevante Interesse Nazionale/ GR - CUP B53C23002130006/PHD fellowship from the European Union - Next Generation EU, Mission 4 Component 1/ PT - Journal Article PL - United States TA - Infancy JT - Infancy : the official journal of the International Society on Infant Studies JID - 100890607 SB - IM MH - Humans MH - Infant MH - Female MH - *Mother-Child Relations/psychology MH - Male MH - *Feeding Behavior/psychology MH - *Communication MH - *Weaning MH - Infant Nutritional Physiological Phenomena MH - Meals MH - *Infant Behavior/psychology MH - Adult MH - *Maternal Behavior MH - Mothers/psychology PMC - PMC12706132 COIS- The authors declare no conflicts of interest. EDAT- 2025/12/16 06:29 MHDA- 2025/12/16 06:30 PMCR- 2025/12/16 CRDT- 2025/12/16 03:09 PHST- 2025/12/02 00:00 [revised] PHST- 2025/04/13 00:00 [received] PHST- 2025/12/08 00:00 [accepted] PHST- 2025/12/16 06:30 [medline] PHST- 2025/12/16 06:29 [pubmed] PHST- 2025/12/16 03:09 [entrez] PHST- 2025/12/16 00:00 [pmc-release] AID - INFA70060 [pii] AID - 10.1111/infa.70060 [doi] PST - ppublish SO - Infancy. 2025 Nov-Dec;30(6):e70060. doi: 10.1111/infa.70060. PMID- 41399024 OWN - NLM STAT- MEDLINE DCOM- 20251216 LR - 20251219 IS - 1468-3148 (Electronic) IS - 1360-2322 (Print) IS - 1360-2322 (Linking) VI - 38 IP - 6 DP - 2025 Nov TI - Assessing the Right to Interpersonal Relationships, Home and Family for People With Intellectual Disabilities. PG - e70163 LID - 10.1111/jar.70163 [doi] LID - e70163 AB - BACKGROUND: The Convention on the Rights of Persons with Disabilities recognises in Article 23 the right to marriage, family, parenthood and interpersonal relationships. However, monitoring this right is challenging due to a lack of evaluation tools. METHOD: This study presents the psychometric validation of items assessing Article 23, which makes up the interpersonal relationships subscale of the #Rights4MeToo Scale, based on responses from 1215 people with intellectual disabilities, family members and professionals. RESULTS: The findings revealed a final unidimensional 7-item structure, high internal consistency, full invariance across gender and partial invariance across respondent types. CONCLUSIONS: This subscale is established as a helpful tool with adequate evidence of validity and reliability for assessing the respect and exercise of this right, with significant implications for support planning and public policy concerning sexual and sentimental relationships, ultimately enhancing the quality of life for people with intellectual disabilities. CI - (c) 2025 The Author(s). Journal of Applied Research in Intellectual Disabilities published by John Wiley & Sons Ltd. FAU - Perez-Curiel, Patricia AU - Perez-Curiel P AUID- ORCID: 0009-0005-8409-161X AD - Departamento de Psicologia y Sociologia, Universidad de Zaragoza, Zaragoza, Spain. FAU - Vicente, Eva AU - Vicente E AUID- ORCID: 0000-0003-0394-5205 AD - Departamento de Psicologia y Sociologia, Universidad de Zaragoza, Zaragoza, Spain. FAU - Moran, M Lucia AU - Moran ML AUID- ORCID: 0000-0001-5650-6711 AD - Departamento de Educacion. Universidad de Cantabria, Santander, Spain. FAU - Martinez-Isla, Estefania AU - Martinez-Isla E AUID- ORCID: 0009-0006-9123-0259 AD - Departamento de Psicologia, Universidad de Oviedo, Oviedo, Spain. FAU - Gomez, Laura E AU - Gomez LE AUID- ORCID: 0000-0002-0776-1836 AD - Departamento de Psicologia, Universidad de Oviedo, Oviedo, Spain. LA - eng GR - PID2019-105737RB-I00/Ministerio de Ciencia, Innovacion y Universidades (MCIU); the Agencia Estatal de Investigacion (AEI) and the Fondo Europeo de Desarrollo Regional (FEDER) (10.13039/501100011033)/ PT - Journal Article PL - England TA - J Appl Res Intellect Disabil JT - Journal of applied research in intellectual disabilities : JARID JID - 9613616 SB - IM MH - Humans MH - *Intellectual Disability/psychology MH - Male MH - Female MH - Adult MH - *Interpersonal Relations MH - Middle Aged MH - *Psychometrics/standards/instrumentation MH - *Family/psychology MH - Reproducibility of Results MH - Young Adult MH - *Human Rights MH - Aged MH - Adolescent PMC - PMC12706181 OAB - Evidence of validity and reliability is provided for a scale measuring Article 23 of the CRPD, demonstrating a unidimensional structure, high reliability and consistency across gender and respondent type. This tool supports people with intellectual disabilities in learning about their rights and making decisions about intimacy, love and family life. This scale is helpful for monitoring how these rights are fulfilled, thereby guiding more inclusive services and rights-based planning. Policymakers must create inclusive frameworks and resources that support the rights of people with intellectual disabilities to form relationships and families, fostering their quality of life and ensuring their full citizenship. OABL- eng OTO - NOTNLM OT - CRPD OT - equality OT - gender OT - intellectual developmental disorder OT - sexuality OT - validation COIS- The authors declare no conflicts of interest. EDAT- 2025/12/16 06:28 MHDA- 2025/12/16 06:29 PMCR- 2025/12/16 CRDT- 2025/12/16 01:55 PHST- 2025/09/08 00:00 [revised] PHST- 2025/06/03 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2025/12/16 06:29 [medline] PHST- 2025/12/16 06:28 [pubmed] PHST- 2025/12/16 01:55 [entrez] PHST- 2025/12/16 00:00 [pmc-release] AID - JAR70163 [pii] AID - 10.1111/jar.70163 [doi] PST - ppublish SO - J Appl Res Intellect Disabil. 2025 Nov;38(6):e70163. doi: 10.1111/jar.70163. PMID- 41398948 OWN - NLM STAT- MEDLINE DCOM- 20251216 LR - 20260919 IS - 1471-2474 (Electronic) IS - 1471-2474 (Linking) VI - 26 IP - 1 DP - 2025 Dec 15 TI - Discriminative efficacy and comparative analysis of functional performance tests for lower-limb injuries in Chinese elite female basketball athletes: a pilot cross-sectional study. PG - 1096 LID - 10.1186/s12891-025-09398-x [doi] LID - 1096 AB - BACKGROUND: Elite female basketball players experience a high incidence of lower-limb injuries, yet evidence remains limited regarding the applicability of common functional performance tests in this population. This study aimed (1) to compare the performance of the Functional Movement Screen (FMS), Landing Error Scoring System (LESS), and Y-Balance Test (YBT) between athletes with and without knee or ankle/foot injuries, and (2) to examine the correlations among these three functional performance tests. METHODS: Eighteen elite female basketball players from the Chinese National Team completed three functional performance tests: FMS, LESS, and YBT. Differences in total and subtest scores between injured and non-injured athletes were analyzed using independent samples t-tests and the Mann-Whitney U test. Spearman correlation analysis was conducted to examine relationships among the three tests. RESULTS: No significant differences were found in total FMS, LESS, or YBT scores between injured and non-injured athletes. However, a large effect size suggested a potential clinical trend between knee injuries and total FMS scores, and the FMS Deep Squat subtest significantly differentiated athletes with knee injuries. No significant correlations were observed among FMS, LESS, and YBT scores. CONCLUSION: The FMS Deep Squat component may help identify knee-related functional limitations in elite female basketball players, while the three tests collectively provide complementary perspectives on movement quality assessment in applied settings. However, given the small sample and cross-sectional design, these findings should be interpreted as exploratory and warrant validation in larger, prospective studies. CI - (c) 2025. The Author(s). FAU - Zhang, Lu AU - Zhang L AD - The Rehabilitation Center of National Sports Training Center, No. 2, A Jia, Tiyuguan Road, Dongcheng District, Beijing, 100061, China. FAU - Xiong, Xingjian AU - Xiong X AD - School of Sports Medicine and Rehabilitation, Beijing Sport University, No. 48 Xinxi Rd, Haidian District, Beijing, Beijing, 100084, China. FAU - Zhang, Muxi AU - Zhang M AD - The Rehabilitation Center of National Sports Training Center, No. 2, A Jia, Tiyuguan Road, Dongcheng District, Beijing, 100061, China. FAU - Zhang, Enming AU - Zhang E AD - School of Sports Medicine and Rehabilitation, Beijing Sport University, No. 48 Xinxi Rd, Haidian District, Beijing, Beijing, 100084, China. zhangenming@bsu.edu.cn. AD - Key Laboratory for Performance Training and Recovery of General Administration of Sport, Beijing Sport University, No. 48 Xinxi Rd, Haidian District, Beijing, 100084, China. zhangenming@bsu.edu.cn. LA - eng PT - Comparative Study PT - Journal Article DEP - 20251215 PL - England TA - BMC Musculoskelet Disord JT - BMC musculoskeletal disorders JID - 100968565 SB - IM MH - Humans MH - Female MH - *Basketball/injuries MH - Cross-Sectional Studies MH - Pilot Projects MH - Young Adult MH - China/epidemiology MH - *Exercise Test/methods/standards MH - *Athletic Injuries/diagnosis/epidemiology/physiopathology MH - Athletes MH - Adult MH - Adolescent MH - *Knee Injuries/diagnosis/physiopathology MH - *Lower Extremity/injuries MH - *Ankle Injuries/diagnosis/physiopathology MH - *Physical Functional Performance PMC - PMC12706911 OTO - NOTNLM OT - Correlation OT - Elite female basketball athletes OT - Functional performance tests OT - Sports injury COIS- Declarations. Ethics approval and consent to participate: This research was carried out in compliance with the ethical guidelines stipulated in the Declaration of Helsinki. The authors have thoroughly addressed ethical considerations, encompassing informed consent, plagiarism, data manipulation, misconduct, potential falsification, instances of double publication or redundancy, and submission procedures. Sports Science Experiment Ethics Committee of Beijing Sport University reviewed and approved the experiments at Beijing Sport University (Ethics Approval Code:2025300 H). All participants were registered and evaluated at a single location after reading and signing the informed consent form. This form was approved by the Sports Science Experiment Ethics Committee of Beijing Sport University. Consent for publication: Written informed consent was secured from the individuals to share their characteristics without their names with the journal if necessary. Competing interests: The authors declare no competing interests. EDAT- 2025/12/16 06:29 MHDA- 2025/12/16 06:30 PMCR- 2025/12/15 CRDT- 2025/12/16 01:47 PHST- 2025/07/01 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2025/12/16 06:30 [medline] PHST- 2025/12/16 06:29 [pubmed] PHST- 2025/12/16 01:47 [entrez] PHST- 2025/12/15 00:00 [pmc-release] AID - 10.1186/s12891-025-09398-x [pii] AID - 9398 [pii] AID - 10.1186/s12891-025-09398-x [doi] PST - epublish SO - BMC Musculoskelet Disord. 2025 Dec 15;26(1):1096. doi: 10.1186/s12891-025-09398-x. PMID- 41398899 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20261004 IS - 1522-726X (Electronic) IS - 1522-1946 (Linking) VI - 107 IP - 4 DP - 2026 Mar TI - SYNTAX Score as a Predictor of Angiographic Complexity in Stable Angina and Acute Coronary Syndrome Patients. PG - 949-954 LID - 10.1002/ccd.70420 [doi] AB - BACKGROUND: Coronary angiography is the gold standard for assessing coronary artery disease (CAD), while the SYNTAX score (SxS) quantifies lesion complexity. Its prognostic value across clinical settings remains uncertain. This study compared angiographic findings in stable angina and acute coronary syndrome (ACS) using the SxS. METHODS: A prospective study was conducted at Shaikh Zayed Hospital, Lahore, over 12 months, including 156 patients undergoing coronary angiography: stable angina (n = 78) and ACS (n = 78). Patients aged 18-80 years undergoing primary PCI or elective angiography were included, excluding prior PCI or CABG. Demographic and clinical data were collected, and SxS was applied post-angiography. Data were analyzed using SPSS v.25, with p 0.05). However, dyslipidemia was more prevalent in ACS patients (p < 0.05), and the mean SxS was significantly higher in ACS versus stable angina (28.2 +/- 9.9 vs. 23.8 +/- 12.4; p = 0.01), indicating greater angiographic complexity. DISCUSSION: The higher SxS in ACS patients indicated greater angiographic complexity, consistent with prior studies. Scores were also significantly elevated in patients with diabetes and hypertension, supporting the score's prognostic value in CAD stratification. However, the absence of clinical variables limits risk prediction. The single-center design, small sample size, lack of adjusted analyses, and absence of long-term outcomes further constrain generalizability, warranting validation in larger multicenter cohorts. CONCLUSION: The SxS was significantly higher in ACS than stable angina, supporting its role in guiding management, particularly in patients with comorbidities. Larger multicenter studies are needed to validate its prognostic utility. CI - (c) 2025 Wiley Periodicals LLC. FAU - Ashraf, Sohaib AU - Ashraf S AUID- ORCID: 0000-0003-3127-3557 AD - Department of Cardiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. AD - Rehmatul Lil Alameen post graduate Institute of cardiology PESSI Multan Road, Lahore, Pakistan. FAU - Mujtaba, Amjad AU - Mujtaba A AD - Department of Cardiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. FAU - Akmal, Rutaba AU - Akmal R AD - Department of Pharmacology, King Edward Medical University, Lahore, Pakistan. FAU - Shahab, Muhammad Sarmad AU - Shahab MS AD - Department of Pharmacology, King Edward Medical University, Lahore, Pakistan. FAU - Ahmad, Waseem AU - Ahmad W AD - Department of Internal Medicine, King Edward Medical University, Lahore, Pakistan. FAU - Shahbaz, Amir AU - Shahbaz A AD - Pakistan kidney and liver institute and research center, Lahore, Pakistan. FAU - Imran, Muhammad Ahmad AU - Imran MA AD - Cancer Centre, Howard University Hospital, Washington, USA. FAU - Khalid, Meer Hassan AU - Khalid MH AD - Department of Medicine, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. FAU - Ashraf, Sidra AU - Ashraf S AUID- ORCID: 0000-0002-4254-2583 AD - University of Veterinary and Animal Sciences, Lahore, Pakistan. FAU - Akram, Muhammad Kiwan AU - Akram MK AD - University of Veterinary and Animal Sciences, Lahore, Pakistan. FAU - Bin Naeem, Usama AU - Bin Naeem U AD - Department of Pharmacology, Riphah International University, Islamabad, Pakistan. FAU - Kalsoom, Larab AU - Kalsoom L AD - Department of Medicine, Services Hospital, Lahore, Pakistan. FAU - Farooq, Usama AU - Farooq U AD - Department of Cardiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. FAU - Javed, Zonera AU - Javed Z AD - Department of Cardiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. FAU - Saleem, Muhammad Sikandar AU - Saleem MS AD - Department of Cardiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. FAU - Pari, Anum AU - Pari A AD - Department of Cardiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. FAU - Farooq, Iqra AU - Farooq I AD - Department of Pediatric Surgery, Children's Hospital, Lahore, Pakistan. FAU - Tahir, Zaryab AU - Tahir Z AD - Department of Medicine, Gujrat Medical College, Gujrat, Pakistan. FAU - Tahir, Arbaz AU - Tahir A AD - Department of Medicine, Chughtai Lab, Lahore, Pakistan. FAU - Iqbal, Qurrat Ul Ain AU - Iqbal QUA AD - Department of Medicine, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. FAU - Arshad, Ali AU - Arshad A AD - Department of Cardiology, Punjab Institute of Cardiology, Lahore, Pakistan. FAU - Mujtaba, Muhammad Athar AU - Mujtaba MA AD - Department of Medicine, Central Park Medical College, Lahore, Pakistan. FAU - Batool, Ifrah AU - Batool I AD - Department of Medicine, Independent University Hospital, Faislabad, Pakistan. FAU - Muneer, Siraj Ul AU - Muneer SU AD - Department of Medicine, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. FAU - Rafique, Sundas AU - Rafique S AD - Department of Hematology Oncology, Mayo Hospital, Lahore, Pakistan. FAU - Khalil, Musa AU - Khalil M AD - Department of Internal Medicine, Howard University Hospital, Washington, USA. FAU - Awais, Fatima AU - Awais F AUID- ORCID: 0009-0003-2439-8404 AD - Department of Internal Medicine, King Edward Medical University, Lahore, Pakistan. FAU - Saboor, Qazi Abdul AU - Saboor QA AD - Department of Cardiology, Shaikh Zayed Post-Graduate Medical Complex, Lahore, Pakistan. FAU - Ashraf, Moneeb AU - Ashraf M AD - Department of Pharmacology, King Edward Medical University, Lahore, Pakistan. FAU - Ashraf, Shoaib AU - Ashraf S AD - Department of Biomedical Sciences, Ross University School of Veterinary Medicine (RUSVM), Saint Kitts and Nevis, West Indies. LA - eng PT - Comparative Study PT - Journal Article DEP - 20251215 PL - United States TA - Catheter Cardiovasc Interv JT - Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions JID - 100884139 SB - IM MH - Humans MH - Male MH - Female MH - Middle Aged MH - *Acute Coronary Syndrome/diagnostic imaging/therapy MH - *Angina, Stable/diagnostic imaging/therapy MH - Prospective Studies MH - *Coronary Angiography/methods MH - Aged MH - Predictive Value of Tests MH - Adult MH - Aged, 80 and over MH - Severity of Illness Index MH - Risk Factors MH - Adolescent MH - Young Adult MH - *Coronary Artery Disease/diagnostic imaging/therapy MH - Pakistan MH - Prognosis MH - Risk Assessment MH - *Coronary Vessels/diagnostic imaging OTO - NOTNLM OT - ACS OT - CAD OT - CYP2C19 OT - SYNTAX EDAT- 2025/12/16 06:28 MHDA- 2026/03/07 06:39 CRDT- 2025/12/16 01:05 PHST- 2025/11/24 00:00 [revised] PHST- 2025/10/10 00:00 [received] PHST- 2025/12/03 00:00 [accepted] PHST- 2026/03/07 06:39 [medline] PHST- 2025/12/16 06:28 [pubmed] PHST- 2025/12/16 01:05 [entrez] AID - 10.1002/ccd.70420 [doi] PST - ppublish SO - Catheter Cardiovasc Interv. 2026 Mar;107(4):949-954. doi: 10.1002/ccd.70420. Epub 2025 Dec 15. PMID- 41398784 OWN - NLM STAT- MEDLINE DCOM- 20251216 LR - 20260102 IS - 1536-5964 (Electronic) IS - 0025-7974 (Print) IS - 0025-7974 (Linking) VI - 104 IP - 50 DP - 2025 Dec 12 TI - Exploring the impact of auricular acupressure and nutritional assistance, enhanced with ferulic acid supplementation, on pediatric cough variant asthma: An observational study. PG - e46106 LID - 10.1097/MD.0000000000046106 [doi] LID - e46106 AB - Cough variant asthma (CVA) is a common cause of chronic cough in children and significantly affects their health and quality-of-life. To explore potential complementary treatment strategies, we conducted a retrospective observational study evaluating the clinical outcomes of auricular acupressure combined with nutritional assistance supplemented with ferulic acid in pediatric CVA. Medical records of 236 children diagnosed with CVA and treated at the Department of Traditional Chinese Medicine, Gongli Hospital of Shanghai Pudong, between April 2022 and November 2024, were reviewed. Based on treatment received, patients were categorized into a treatment group (auricular acupressure plus ferulic acid supplementation) or a control group (standard care only). Primary outcomes were changes in the Cough Severity Index (CSI), while secondary outcomes included Pediatric Asthma Quality of Life Questionnaire (PAQLQ) scores and pulmonary function tests. At 3, 6, and 12 months, the treatment group showed significantly greater reductions in CSI scores (P < .05) compared with controls. Improvements in lung function indices (FEV1, FVC) were also more pronounced in the treatment group (P < .01). Additionally, quality-of-life scores increased significantly among patients receiving the integrative therapy. These findings suggest that, in this retrospective cohort, the combination of auricular acupressure with ferulic acid supplementation was associated with enhanced symptom relief, lung function, and quality of life in children with CVA. This integrative approach warrants further prospective and randomized investigations to validate its clinical value. CI - Copyright (c) 2025 the Author(s). Published by Wolters Kluwer Health, Inc. FAU - Ye, Lu AU - Ye L AUID- ORCID: 0009-0008-4000-2656 AD - Department of TCM, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China. FAU - Guo, Yan-Fang AU - Guo YF AD - Department of Pediatrics, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China. FAU - Zhou, Jin AU - Zhou J AD - Department of Pediatrics, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China. FAU - Mi, Ying-Ying AU - Mi YY AD - Department of Pediatrics, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China. FAU - Zhao, Jie AU - Zhao J AD - Department of TCM, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China. FAU - Cao, Xiao-Wen AU - Cao XW AD - Department of TCM, Gongli Hospital of Shanghai Pudong New Area, Shanghai, China. LA - eng GR - 2020LP046/Traditional Chinese Medicine Research Project of Shanghai Municipal Health Commission/ GR - PWRzm2020-07/Project Leaderi(1/4)OELe-yi Du. Key Specialty of Pudong New Area/ GR - SHGZS-202218/Le-yi Du. Key Specialty of Pudong New Area (Pulmonary Disease of TCM)/ PT - Journal Article PT - Observational Study PL - United States TA - Medicine (Baltimore) JT - Medicine JID - 2985248R RN - AVM951ZWST (ferulic acid) RN - 0 (Coumaric Acids) SB - IM MH - Humans MH - Male MH - Retrospective Studies MH - Female MH - *Asthma/therapy MH - Child MH - *Cough/therapy MH - *Coumaric Acids/therapeutic use/administration & dosage MH - Quality of Life MH - *Acupressure/methods MH - Dietary Supplements MH - Child, Preschool MH - Treatment Outcome MH - Respiratory Function Tests MH - Severity of Illness Index MH - Combined Modality Therapy MH - Cough-Variant Asthma PMC - PMC12708130 OTO - NOTNLM OT - auricular acupressure OT - ferulic acid OT - lung function OT - nutritional supplementation OT - pediatric cough variant asthma COIS- The authors have no conflicts of interest to disclose. EDAT- 2025/12/16 06:28 MHDA- 2025/12/16 06:29 PMCR- 2025/12/12 CRDT- 2025/12/16 01:03 PHST- 2025/08/22 00:00 [received] PHST- 2025/10/23 00:00 [accepted] PHST- 2025/12/16 06:29 [medline] PHST- 2025/12/16 06:28 [pubmed] PHST- 2025/12/16 01:03 [entrez] PHST- 2025/12/12 00:00 [pmc-release] AID - 00005792-202512120-00030 [pii] AID - MD-D-24-15727 [pii] AID - 10.1097/MD.0000000000046106 [doi] PST - ppublish SO - Medicine (Baltimore). 2025 Dec 12;104(50):e46106. doi: 10.1097/MD.0000000000046106. PMID- 41398604 OWN - NLM STAT- MEDLINE DCOM- 20251216 LR - 20251230 IS - 1745-6215 (Electronic) IS - 1745-6215 (Linking) VI - 26 IP - 1 DP - 2025 Dec 15 TI - Social ecological model for developing health-promoting schools and improving healthy eating in female students: a mixed-method protocol study in Iran. PG - 566 LID - 10.1186/s13063-025-09278-8 [doi] LID - 566 AB - BACKGROUND: The concept of health-promoting schools, initiated by the World Health Organization, aims to move beyond individual behavior change and includes changes in the organizational structure, such as improvements in the physical and social environment of the school. By integrating health promotion into all aspects of life, health-promoting schools aim to equip students with the knowledge, skills, and supportive environment required to make healthy choices and develop lifelong healthy behaviors. The present study will aim to apply the social-ecological model in establishing health-promoting schools and improving healthy eating behavior in female students on the basis of social cognitive theory (SCT) in Bastak County, Hormozgan Province, southern Iran. METHODS: The present exploratory mixed-methods study will be conducted in four phases: qualitative, instrumental, cross-sectional, and interventional. The qualitative phase will continue until data saturation. On the basis of the concepts that will be extracted in the qualitative phase, the SCT questionnaire will be designed and psychometrically validated. In the cross-sectional phase, effective factors for establishing a health-promoting school and promoting healthy eating behaviors will be identified, and in the intervention phase, necessary interventions will be designed in accordance with health promotion strategies and will be implemented in the selected school serving as the intervention group. To evaluate the impact of the intervention, both intervention and control groups will be assessed in terms of healthy eating behavior before and 3 months after the intervention. The social-ecological model will be employed as the guiding framework for the development and implementation of school-based health promotion interventions throughout the study. DISCUSSION: The aim of this study will be to design a program to establish a health-promoting school and improve healthy eating behaviors in students on the basis of the Health-Promoting School Checklist and the SCT model. The social-ecological model will also be used as a guiding framework in the design and implementation of the school-based interventions. The outcomes of this intervention will contribute to a deeper understanding of the factors that will influence the promotion of healthy eating behaviors in students. The findings will be effective in the process of developing health-promoting schools and fostering healthy eating behaviors in adolescents. TRIAL REGISTRATION: Iranian Registry of Clinical Trials IRCT20241123063812N1. Registered on 14 May 2025. CI - (c) 2025. The Author(s). FAU - Pourjalil, Farzaneh AU - Pourjalil F AD - Student Research Committee, Faculty of Health, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. FAU - Shahabi, Nahid AU - Shahabi N AD - Department of Health Education and Health Promotion, School of Health, Social Determinants in Health Promotion Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. FAU - Hosseini, Zahra AU - Hosseini Z AD - Department of Health Education and Health Promotion, School of Health, Social Determinants in Health Promotion Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. hosseinishirin@ymail.com. FAU - Aghamolaei, Teamur AU - Aghamolaei T AD - Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20251215 PL - England TA - Trials JT - Trials JID - 101263253 SB - IM MH - Humans MH - Female MH - Iran MH - *Diet, Healthy MH - *Health Promotion/methods/organization & administration MH - *School Health Services/organization & administration MH - Cross-Sectional Studies MH - Adolescent MH - *Students/psychology MH - Child MH - *Social Environment MH - Health Knowledge, Attitudes, Practice MH - *Adolescent Behavior MH - Health Behavior MH - Feeding Behavior MH - Child Behavior MH - Schools PMC - PMC12707007 OTO - NOTNLM OT - Ecological model of health OT - Health-promoting schools OT - Healthy eating behavior OT - Social cognitive theory COIS- Declarations. Ethics approval and consent to participate 24: All methods will be performed in accordance with the Declaration of Helsinki. The study was approved by the Ethics Committee of Hormozgan University of Medical Sciences (ethical code IR.HUMS.REC.1403.270). All participants provided written consent to participate in this study. Consent for publication 32: This is not applicable, as no identifying images or other personal or clinical details of the participants are presented here or will be presented in reports of the trial results. Informed consent materials are available from the corresponding author upon request. Competing interests 28: The authors declare that they have no competing interests. EDAT- 2025/12/16 06:29 MHDA- 2025/12/16 06:30 PMCR- 2025/12/15 CRDT- 2025/12/16 00:38 PHST- 2025/05/23 00:00 [received] PHST- 2025/10/30 00:00 [accepted] PHST- 2025/12/16 06:30 [medline] PHST- 2025/12/16 06:29 [pubmed] PHST- 2025/12/16 00:38 [entrez] PHST- 2025/12/15 00:00 [pmc-release] AID - 10.1186/s13063-025-09278-8 [pii] AID - 9278 [pii] AID - 10.1186/s13063-025-09278-8 [doi] PST - epublish SO - Trials. 2025 Dec 15;26(1):566. doi: 10.1186/s13063-025-09278-8. PMID- 41398496 OWN - NLM STAT- MEDLINE DCOM- 20260102 LR - 20260118 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 29 IP - 1 DP - 2025 Dec 16 TI - Prevalence and factors associated with regular fast-food consumption among adults in the UAE: a cross-sectional study. PG - e2 LID - 10.1017/S1368980025101560 [doi] LID - e2 AB - OBJECTIVES: To assess the prevalence and identify sociodemographic predictors of regular fast-food consumption (R-FFC) among United Arab Emirates (UAE) adults to inform public health nutrition responses to growing diet-related ill health in the region. DESIGN: This is a descriptive cross-sectional study using purposive, convenience sampling. Data were collected using an online survey adapted from two validated surveys and distributed via social media platforms. R-FFC was defined as visiting a fast-food restaurant to eat >/= 2 times/week. Pearson's chi(2) tests and multiple binary logistic regression models were used to investigate prevalence and predictors of R-FFC. All statistical significance was considered at P-value < 0.05. SETTING: Community, adults living in the UAE. PARTICIPANTS: UAE residents, >/= 18 years, who consumed fast food >/= once during the previous month. RESULTS: Totally, 320 respondents met the inclusion criteria (age = mean 23.7 (sd 7.7) years). The prevalence of R-FFC was 46.6 %. Based on results from the regression model, predictors of R-FFC were being female (AOR 2.47; 95 % CI 1.06, 5.79), married (AOR 3.11; 95 % CI 1.25, 7.77), BMI >/= 25.0 (AOR 2.09; 95 % CI 1.10, 4.00) and residing outside Abu Dhabi (AOR 32.79; 95 % CI 12.06, 89.16). None of the remaining variables reached statistical significance. Taste was the most common reason for FFC (56.9 %), followed by convenience (21.6 %). Regular fast-food consumers were more likely to 'super-size' meals (P = 0.011), eat alone (P = 0.009) and not have regular meal patterns (P = 0.004). CONCLUSIONS: The study revealed a high prevalence of R-FFC among UAE adults, and novel cultural predictors and characteristics of FFC in this context, highlighting the importance of socially and culturally informed research and public health strategies in this region. FAU - Al Rajabi, Ala AU - Al Rajabi A AUID- ORCID: 0000-0003-2426-6279 AD - Department of Nutrition Sciences, College of Health Science, QU Health, Qatar University, Doha, Qatar. FAU - Hijazi, Rafiq AU - Hijazi R AD - Department of Mathematics and Statistics, College of Natural and Health Sciences, Zayed University, Abu Dhabi, UAE. FAU - Kennedy, Lynne Alexandra AU - Kennedy LA AUID- ORCID: 0000-0002-4699-2602 AD - Department of Health Sciences, College of Natural and Health Sciences, https://ror.org/03snqfa66Zayed University, Abu Dhabi, UAE. LA - eng PT - Journal Article DEP - 20251216 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - United Arab Emirates/epidemiology MH - Cross-Sectional Studies MH - Female MH - Male MH - Adult MH - *Fast Foods/statistics & numerical data MH - Prevalence MH - Young Adult MH - *Diet/statistics & numerical data MH - *Feeding Behavior MH - Middle Aged MH - Adolescent MH - Surveys and Questionnaires MH - Restaurants/statistics & numerical data MH - Socioeconomic Factors PMC - PMC12809606 OTO - NOTNLM OT - Dietary habits OT - Fast food OT - Non-communicable diseases OT - Obesity OT - Public health OT - Regular fast-food consumption OT - UAE COIS- The authors declare no competing interests. EDAT- 2025/12/16 06:29 MHDA- 2026/01/02 06:29 PMCR- 2025/12/16 CRDT- 2025/12/16 00:12 PHST- 2026/01/02 06:29 [medline] PHST- 2025/12/16 06:29 [pubmed] PHST- 2025/12/16 00:12 [entrez] PHST- 2025/12/16 00:00 [pmc-release] AID - S1368980025101560 [pii] AID - 10.1017/S1368980025101560 [doi] PST - epublish SO - Public Health Nutr. 2025 Dec 16;29(1):e2. doi: 10.1017/S1368980025101560. PMID- 41398348 OWN - NLM STAT- MEDLINE DCOM- 20260116 LR - 20260118 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2025 Dec 15 TI - Proteome-wide mendelian randomization reveals circulating proteins causally associated with childhood body mass index. PG - 2093 LID - 10.1038/s41598-025-31836-y [doi] LID - 2093 AB - Childhood obesity is a major public health problem, affecting one in 5 youths. We aimed to characterize biomarkers for pediatric obesity among circulating proteins using Mendelian randomization (MR). We utilized genome-wide significant cis-protein quantitative trait loci (pQTL) from three large adult proteomic GWAS (N total>58,000) and a small childhood proteomic GWAS (N=2,147) as genetic instruments for circulating protein levels. Using two-sample Mendelian randomization, we estimated causal effects of the circulating proteins on childhood body mass index (BMI) in a European GWAS of 39,620 children. MR Wald ratios were calculated to estimate the causal effect of each protein on childhood BMI. Sensitivity analyses testing the MR assumptions included colocalization and phenome-wide association studies (PheWAS). Replication was conducted using independent GWAS datasets, complemented by reverse MR and tissue enrichment analyses. Among 535 tested proteins, three colocalized and demonstrated decreasing effects on BMI per standard deviation increase in their level: endoglin (ENG; MR beta: -0.07, 95% CI [-0.10, -0.04], P=4.4x10(-)(5)), fatty acid binding protein 4 (FABP4; MR beta: -0.33, 95% CI [-0.50, -0.16], P=1.3x10(-)(4)), and cell adhesion molecule 1 (CADMI1; MR beta: -0.26, 95% CI [-0.37, -0.15], P=5.45x10(-)(5)). All three proteins showed evidence of colocalization (posterior probability >75%) and were identified using adult proteomic GWAS, given a limited statistical power using the pediatric proteomic GWAS data. Reverse causation was identified for FABP4, suggesting a compensatory mechanism. In conclusion, we identified three circulating proteins as potential blood biomarkers or drug targets for pediatric obesity, warranting further functional validation to elucidate biological mechanisms and assess therapeutic potential. CI - (c) 2025. The Author(s). FAU - Avocegamou, Raphael AU - Avocegamou R AD - Azrieli Research Center of the Sainte-Justine University Hospital, CHU Sainte Justine, Universite de Montreal, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. AD - Department of Biochemistry and Molecular Medicine, Universite de Montreal, CHU Sainte Justine, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. FAU - Jumentier, Basile AU - Jumentier B AD - Azrieli Research Center of the Sainte-Justine University Hospital, CHU Sainte Justine, Universite de Montreal, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. FAU - Fagbemi, Kaossarath AU - Fagbemi K AD - Azrieli Research Center of the Sainte-Justine University Hospital, CHU Sainte Justine, Universite de Montreal, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. FAU - Yazdanpanah, Nahid AU - Yazdanpanah N AD - Azrieli Research Center of the Sainte-Justine University Hospital, CHU Sainte Justine, Universite de Montreal, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. FAU - Yazdanpanah, Mojgan AU - Yazdanpanah M AD - Azrieli Research Center of the Sainte-Justine University Hospital, CHU Sainte Justine, Universite de Montreal, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. FAU - Gamache, Isabel AU - Gamache I AD - Azrieli Research Center of the Sainte-Justine University Hospital, CHU Sainte Justine, Universite de Montreal, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. FAU - Manousaki, Despoina AU - Manousaki D AD - Azrieli Research Center of the Sainte-Justine University Hospital, CHU Sainte Justine, Universite de Montreal, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. despina.manousaki@umontreal.ca. AD - Department of Biochemistry and Molecular Medicine, Universite de Montreal, CHU Sainte Justine, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. despina.manousaki@umontreal.ca. AD - Department of Pediatrics, Universite de Montreal, CHU Sainte Justine, 3175 Cote-Sainte-Catherine, Montreal, Quebec, H3T 1C5, Canada. despina.manousaki@umontreal.ca. LA - eng GR - 2025-2026 - CC - 366931/Fonds de Recherche du Quebec - Sante/ PT - Journal Article DEP - 20251215 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Proteome) RN - 0 (Blood Proteins) RN - 0 (Biomarkers) RN - 0 (Fatty Acid-Binding Proteins) SB - IM MH - Humans MH - *Mendelian Randomization Analysis MH - *Body Mass Index MH - Child MH - Genome-Wide Association Study MH - *Pediatric Obesity/genetics/blood MH - Male MH - *Proteome/genetics MH - Female MH - Quantitative Trait Loci MH - *Blood Proteins/genetics MH - Proteomics/methods MH - Biomarkers/blood MH - Fatty Acid-Binding Proteins/blood/genetics MH - Polymorphism, Single Nucleotide MH - Adolescent PMC - PMC12808636 OTO - NOTNLM OT - Causal inference OT - Mendelian randomization OT - Pediatric obesity OT - Proteins COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/12/16 00:35 MHDA- 2026/01/17 04:07 PMCR- 2025/12/15 CRDT- 2025/12/15 23:44 PHST- 2025/07/19 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/01/17 04:07 [medline] PHST- 2025/12/16 00:35 [pubmed] PHST- 2025/12/15 23:44 [entrez] PHST- 2025/12/15 00:00 [pmc-release] AID - 10.1038/s41598-025-31836-y [pii] AID - 31836 [pii] AID - 10.1038/s41598-025-31836-y [doi] PST - epublish SO - Sci Rep. 2025 Dec 15;16(1):2093. doi: 10.1038/s41598-025-31836-y. PMID- 41397491 OWN - NLM STAT- MEDLINE DCOM- 20260110 LR - 20260712 IS - 1873-507X (Electronic) IS - 0031-9384 (Linking) VI - 305 DP - 2026 Mar 1 TI - Continuous testosterone exposure alters body weight, lean mass, estrous cycling and lipid profile, but not wheel running in adolescent or adult female rats. PG - 115206 LID - S0031-9384(25)00407-X [pii] LID - 10.1016/j.physbeh.2025.115206 [doi] AB - Health-related organizations have called for broadening biomedical research to include gender-diverse individuals. The present study tested the validity of an animal model of gender affirming testosterone therapy that may be useful for determining the impact of hormonal transition on a variety of health outcomes in both adolescents and adults. Blank or testosterone-filled capsules were implanted s.c. into gonadally intact adolescent (post-natal day 43) and adult (post-natal day 92) female rats. Body weight, estrous cycling, and home cage wheel running were recorded for 3 weeks; other physiological indices of defeminization and masculinization were assessed 29-30 days after capsule implantation. Testosterone treatment at male-typical levels suppressed estrous cycling and uterine weight, increased body weight and lean mass, and increased low density lipoprotein levels in both adolescents and adults. Testosterone increased clitoral gland size in adolescents. In contrast, wheel running was not significantly altered by testosterone. Results suggest that testosterone exposure at male-typical levels in gonadally intact female rats - whether adolescent or adult at the initiation of treatment - is a valid model of gender affirming testosterone therapy in terms of hormone impact on a variety of physiological measures. This model can thus provide a clinically relevant avenue for advancing transgender medicine. CI - Copyright (c) 2025. Published by Elsevier Inc. FAU - Craft, Rebecca M AU - Craft RM AD - Department of Psychology, Washington State University, Pullman and Vancouver, WA, USA. Electronic address: craft@wsu.edu. FAU - Calvert, Alexa R AU - Calvert AR AD - Department of Psychology, Washington State University, Pullman and Vancouver, WA, USA. FAU - Spencer, Faith AU - Spencer F AD - Department of Psychology, Washington State University, Pullman and Vancouver, WA, USA. FAU - Morgan, Michael M AU - Morgan MM AD - Department of Psychology, Washington State University, Pullman and Vancouver, WA, USA. LA - eng PT - Journal Article DEP - 20251213 PL - United States TA - Physiol Behav JT - Physiology & behavior JID - 0151504 RN - 3XMK78S47O (Testosterone) RN - 0 (Lipids) SB - IM MH - Animals MH - Female MH - *Testosterone/pharmacology/administration & dosage MH - *Estrous Cycle/drug effects MH - *Body Weight/drug effects MH - Rats MH - Organ Size/drug effects MH - Male MH - *Motor Activity/drug effects MH - *Lipids/blood MH - *Body Composition/drug effects MH - Rats, Sprague-Dawley MH - Age Factors OTO - NOTNLM OT - Blood lipids OT - Body composition OT - Defeminization OT - Hormone therapy OT - Masculinization COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2025/12/16 00:34 MHDA- 2026/01/11 00:34 CRDT- 2025/12/15 19:34 PHST- 2025/11/07 00:00 [received] PHST- 2025/12/03 00:00 [revised] PHST- 2025/12/12 00:00 [accepted] PHST- 2026/01/11 00:34 [medline] PHST- 2025/12/16 00:34 [pubmed] PHST- 2025/12/15 19:34 [entrez] AID - S0031-9384(25)00407-X [pii] AID - 10.1016/j.physbeh.2025.115206 [doi] PST - ppublish SO - Physiol Behav. 2026 Mar 1;305:115206. doi: 10.1016/j.physbeh.2025.115206. Epub 2025 Dec 13. PMID- 41397488 OWN - NLM STAT- MEDLINE DCOM- 20260129 LR - 20260828 IS - 1872-7697 (Electronic) IS - 0167-8760 (Print) IS - 0167-8760 (Linking) VI - 220 DP - 2026 Feb TI - The effects of acute aerobic exercise on stressor-evoked physiological and psychological responses. PG - 113309 LID - S0167-8760(25)00805-0 [pii] LID - 10.1016/j.ijpsycho.2025.113309 [doi] AB - Psychological stress is associated with adverse physical and mental health outcomes. Previous research has suggested that acute exercise may reduce cardiovascular reactivity to acute psychological stress. However, studies examining the effects of acute exercise on stressor-evoked cardiovascular and psychological responses to stress are somewhat limited. The aim of the present study was to examine whether a 10-min bout of aerobic exercise at 70 % VO(2max) attenuated stressor-evoked physiological and psychological responses. Forty participants (20 female, 20 male; age: Mean = 19.95; SD = 1.93 years) completed a randomized, counterbalanced crossover protocol involving two stress sessions: (1) stress only and (2) stress after exercise. Cardiovascular (SBP, DBP, HR) and metabolic (VO(2)) responses were assessed at rest and during a validated acute psychological stress task and psychological responses (cognitive and somatic anxiety intensity and interpretation; stress intensity) were assessed immediately after the stress task. There were significant session x time effects for blood pressure and heart rate. Stressor-evoked blood pressure and heart rate were significantly lower in the stress after exercise session compared to the stress only session. No session effects were observed for VO(2). Participants reported experiencing significantly lower somatic anxiety and higher stress intensity in the stress after exercise session compared to the stress only session. Brief aerobic exercise may be beneficial in reducing stressor-evoked cardiovascular and somatic anxiety responses. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Ginty, Annie T AU - Ginty AT AD - Department of Psychology and Neuroscience, Baylor University, Waco, TX, 76798, United States of America. Electronic address: Annie_Ginty@baylor.edu. FAU - Trotman, Gavin P AU - Trotman GP AD - School of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom. FAU - Hogue, Anna G AU - Hogue AG AD - College of Behavioural, Social, and Health Science, Clemson University, Clemson, SC, United States of America. FAU - Knauft, Katherine M AU - Knauft KM AD - Department of Psychology and Neuroscience, Baylor University, Waco, TX, 76798, United States of America. FAU - Veldhuijzen van Zanten, Jet J C S AU - Veldhuijzen van Zanten JJCS AD - School of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom. FAU - Williams, Sarah E AU - Williams SE AD - School of Sport, Exercise, and Rehabilitation Sciences, University of Birmingham, Edgbaston, Birmingham, United Kingdom. LA - eng GR - K01 HL145021/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial DEP - 20251213 PL - Netherlands TA - Int J Psychophysiol JT - International journal of psychophysiology : official journal of the International Organization of Psychophysiology JID - 8406214 SB - IM MH - Humans MH - Female MH - Male MH - *Stress, Psychological/physiopathology/psychology MH - Young Adult MH - *Exercise/physiology/psychology MH - *Heart Rate/physiology MH - *Blood Pressure/physiology MH - Cross-Over Studies MH - Adult MH - Oxygen Consumption/physiology MH - Anxiety/physiopathology MH - Adolescent PMC - PMC13519942 MID - NIHMS2197091 OTO - NOTNLM OT - Acute psychological stress OT - Blood pressure OT - Exercise EDAT- 2025/12/16 00:34 MHDA- 2026/01/30 00:54 PMCR- 2026/12/13 CRDT- 2025/12/15 19:33 PHST- 2025/09/26 00:00 [received] PHST- 2025/12/08 00:00 [revised] PHST- 2025/12/10 00:00 [accepted] PHST- 2026/01/30 00:54 [medline] PHST- 2025/12/16 00:34 [pubmed] PHST- 2025/12/15 19:33 [entrez] PHST- 2026/12/13 00:00 [pmc-release] AID - S0167-8760(25)00805-0 [pii] AID - 10.1016/j.ijpsycho.2025.113309 [doi] PST - ppublish SO - Int J Psychophysiol. 2026 Feb;220:113309. doi: 10.1016/j.ijpsycho.2025.113309. Epub 2025 Dec 13. PMID- 41396243 OWN - NLM STAT- MEDLINE DCOM- 20260901 LR - 20260904 IS - 1920-7476 (Electronic) IS - 0008-4263 (Print) IS - 0008-4263 (Linking) VI - 117 IP - 4 DP - 2026 Aug TI - Identifying patients with obesity from health administrative data: Diagnostic accuracy of surgical billing claims. PG - 753-763 LID - 10.17269/s41997-025-01114-5 [doi] AB - OBJECTIVES: Obesity (body mass index, BMI >/= 30 kg/m(2)) is a predictor of patient outcomes across surgical disciplines, but is not accurately captured by diagnostic codes in administrative databases. The objective of this study was to determine the validity of surgeon and anaesthetist billing claims indicating that their patients had concurrent class III obesity (BMI > 40) as compared to patients' self-reported BMI. METHODS: We performed a cross-sectional study of adult patients who had undergone major abdominopelvic, neck, and hip surgery in Ontario from 2011 to 2019, and had also reported their BMI on either the Canadian Community Health Survey or the Ontario Health Study. Physician billing claims for class III obesity were compared to self-reported BMI, and measures of diagnostic accuracy with 95% confidence intervals were calculated. RESULTS: We identified 52,515 patients who had undergone surgery (80.6% abdominopelvic; 19.4% neck/hip) with median age 57 years and median BMI 26 (range 15-108); 2189 patients (4.2%) reported a BMI > 40. When self-reported BMI was collected within 1 year of surgery, billing claims submitted by either the surgeon, surgical assistant, or anaesthetist had sensitivity 82.9% (95% CI 79.1-86.7), specificity 95.5% (95.0-96.0), positive predictive value 52.9% (50.1-58.5), and negative predictive value 98.9% (98.7-99.2) for the identification of BMI > 40. Positive predictive value for the identification of BMI > 30 was 95.4% (93.7-97.0). CONCLUSION: Physician billing claims are specific and sensitive for the identification of patients with BMI > 40 undergoing surgery, enable accurate selection of a population with BMI > 30, and are valid for use in studies conducted with health administrative data. CI - (c) 2025. The Author(s) under exclusive license to The Canadian Public Health Association. FAU - Cusimano, Maria C AU - Cusimano MC AUID- ORCID: 0000-0002-1661-4846 AD - Department of Obstetrics & Gynecology, University of Toronto, Toronto, ON, Canada. AD - Lahey Hospital & Medical Center, Beth Israel Lahey Health, Burlington, MA, USA. FAU - Baxter, Nancy N AU - Baxter NN AD - ICES (Formerly the Institute for Clinical Evaluative Sciences), Toronto, ON, Canada. AD - Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. AD - Faculty of Medicine and Health, University of Sydney, Sydney, NSW, Australia. FAU - Moineddin, Rahim AU - Moineddin R AD - ICES (Formerly the Institute for Clinical Evaluative Sciences), Toronto, ON, Canada. AD - Department of Family & Community Medicine, University of Toronto, Toronto, ON, Canada. FAU - Chiu, Maria AU - Chiu M AD - ICES (Formerly the Institute for Clinical Evaluative Sciences), Toronto, ON, Canada. AD - Institute of Health Policy, Management, and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada. FAU - Nguyen, Lena AU - Nguyen L AD - ICES (Formerly the Institute for Clinical Evaluative Sciences), Toronto, ON, Canada. FAU - Aktar, Suriya AU - Aktar S AD - ICES (Formerly the Institute for Clinical Evaluative Sciences), Toronto, ON, Canada. FAU - Liu, Ning AU - Liu N AD - ICES (Formerly the Institute for Clinical Evaluative Sciences), Toronto, ON, Canada. FAU - Simpson, Andrea N AU - Simpson AN AD - Department of Obstetrics & Gynecology, University of Toronto, Toronto, ON, Canada. AD - Department of Obstetrics & Gynecology, Unity Health Toronto, St. Michael's Hospital, Toronto, ON, Canada. FAU - Johnson, Christina AU - Johnson C AD - Lahey Hospital & Medical Center, Beth Israel Lahey Health, Burlington, MA, USA. FAU - Ferguson, Sarah E AU - Ferguson SE AD - Department of Obstetrics & Gynecology, University of Toronto, Toronto, ON, Canada. sarah.ferguson@uhn.ca. AD - Division of Gynecologic Oncology, Princess Margaret Cancer Centre/Sinai Health Systems, Toronto, ON, Canada. sarah.ferguson@uhn.ca. LA - eng PT - Journal Article DEP - 20251215 PL - Switzerland TA - Can J Public Health JT - Canadian journal of public health = Revue canadienne de sante publique JID - 0372714 SB - IM MH - Humans MH - Female MH - Middle Aged MH - Male MH - Ontario/epidemiology MH - Cross-Sectional Studies MH - Adult MH - Body Mass Index MH - Aged MH - *Obesity/diagnosis/epidemiology MH - Young Adult MH - Adolescent MH - *Surgical Procedures, Operative/statistics & numerical data MH - *Insurance Claim Review MH - Databases, Factual MH - Self Report PMC - PMC13536496 OTO - NOTNLM OT - Anaesthetists OT - Body mass index OT - Obesity OT - Predictive value of tests OT - Routinely collected health data OT - Surgeons COIS- Declarations. Ethics approval: The Research Ethics Board at the University of Toronto (Toronto, ON, Canada) provided approval (#38212). Consent to participate: Not applicable. Consent for publication: Not applicable. Conflict of interest: The authors declare no competing interests. EDAT- 2025/12/15 13:10 MHDA- 2026/09/01 17:39 PMCR- 2026/12/15 CRDT- 2025/12/15 11:06 PHST- 2025/06/02 00:00 [received] PHST- 2025/09/09 00:00 [accepted] PHST- 2026/09/01 17:39 [medline] PHST- 2025/12/15 13:10 [pubmed] PHST- 2025/12/15 11:06 [entrez] PHST- 2026/12/15 00:00 [pmc-release] AID - 10.17269/s41997-025-01114-5 [pii] AID - 1114 [pii] AID - 10.17269/s41997-025-01114-5 [doi] PST - ppublish SO - Can J Public Health. 2026 Aug;117(4):753-763. doi: 10.17269/s41997-025-01114-5. Epub 2025 Dec 15. PMID- 41396232 OWN - NLM STAT- MEDLINE DCOM- 20251215 LR - 20261010 IS - 1534-3081 (Electronic) IS - 1534-3081 (Linking) VI - 30 IP - 1 DP - 2025 Dec 15 TI - Assessment and Non-pharmacological Management of Chronic Pain in Pediatric Cancer Survivors: Current Practices and Recommendations for Next Steps. PG - 1 LID - 10.1007/s11916-025-01446-4 [doi] AB - PURPOSE OF REVIEW: Chronic pain is a prevalent and debilitating late effect of pediatric cancer. It is also multifaceted and requires comprehensive assessment to guide optimal treatment. While pharmacological interventions for chronic pain in this population are well summarized elsewhere, a current review of less invasive non-pharmacological interventions and assessments to guide them is needed. RECENT FINDINGS: Recent research has found the utility of biopsychosocial assessment of pain in pediatric cancer survivors using both validated measures such as the PROMIS and brief screeners. For intervention, preliminary studies found positive outcomes for physical activity interventions and biofeedback for pain in survivors. Advances in management of chronic pain in survivors are promising, though future research should refine identification and treatment. More research is needed on comprehensive biopsychosocial pain assessments and tailoring treatment. Further, promising interventions in broad chronic pain literature such as hypnosis should be explored for pediatric cancer survivors. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Hayes, Lauren AU - Hayes L AD - Norton Children's Medical Group, Louisville, KY, USA. Lauren.Hayes@louisville.edu. AD - Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA. Lauren.Hayes@louisville.edu. FAU - Pabis, Jacqueline M AU - Pabis JM AD - Norton Children's Medical Group, Louisville, KY, USA. AD - Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA. FAU - Millmann, Megan AU - Millmann M AD - Norton Children's Medical Group, Louisville, KY, USA. AD - Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA. FAU - Milligan, Claire Niehaus AU - Milligan CN AD - Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. FAU - Daffin, Morgan AU - Daffin M AD - Norton Children's Medical Group, Louisville, KY, USA. AD - Department of Pediatrics, University of Louisville School of Medicine, Louisville, KY, USA. LA - eng PT - Journal Article PT - Review DEP - 20251215 PL - United States TA - Curr Pain Headache Rep JT - Current pain and headache reports JID - 100970666 SB - IM MH - Humans MH - *Chronic Pain/therapy/diagnosis/etiology MH - Child MH - *Pain Management/methods MH - *Cancer Survivors MH - *Neoplasms/complications MH - Pain Measurement/methods OTO - NOTNLM OT - Assessment OT - Chronic pain OT - Non-pharmacological management OT - Pediatric cancer OT - Survivorship COIS- Declarations. Competing interests: The authors declare no competing interests. Human and animal rights: This article does not contain any studies with human or animal subjects performed by any of the authors. Disclosure: The authors have no relevant financial or non-financial conflicts of interests to disclose. EDAT- 2025/12/15 13:10 MHDA- 2025/12/15 13:11 CRDT- 2025/12/15 11:06 PHST- 2025/07/30 00:00 [received] PHST- 2025/11/20 00:00 [accepted] PHST- 2025/12/15 13:11 [medline] PHST- 2025/12/15 13:10 [pubmed] PHST- 2025/12/15 11:06 [entrez] AID - 10.1007/s11916-025-01446-4 [pii] AID - 10.1007/s11916-025-01446-4 [doi] PST - epublish SO - Curr Pain Headache Rep. 2025 Dec 15;30(1):1. doi: 10.1007/s11916-025-01446-4. PMID- 41393944 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251215 LR - 20251217 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Associations between the Dietary Inflammatory Index and depression among pregnant and postpartum women: analysis of NHANES 2005-2018. PG - 1681491 LID - 10.3389/fnut.2025.1681491 [doi] LID - 1681491 AB - BACKGROUND: Perinatal depression, which occurs during pregnancy or after childbirth, is a common and serious complication of pregnancy. Chronic low-grade inflammation has been implicated in the pathophysiology of depression. The Dietary Inflammatory Index (DII) is a validated measure of the inflammatory potential of a diet, where higher scores indicate a more proinflammatory diet. This study examined the association between DII and depression among pregnant and postpartum women, with a focus on potential non-linear (threshold) effects. METHODS: We analyzed data from the National Health and Nutrition Examination Survey (NHANES) 2005-2018. The sample included 1,093 women who were either pregnant or in the postpartum period within 18 months. Dietary intake was assessed via 24-h recall, and DII scores were calculated for each participant. Depressive symptoms were measured using the Patient Health Questionnaire-9 (PHQ-9); we defined depression as a PHQ-9 score >/=10, indicating moderate or greater depressive symptoms. Weighted multivariate logistic regression was used to estimate odds ratios (ORs) for depression in relation to DII scores, and weighted linear regression was used to assess the association between DII scores and PHQ-9 total scores. Models were adjusted for potential confounders, including age, race, poverty income ratio, marital status, smoking status, education level, BMI and WBC. We tested for non-linear relationships using a generalized additive model (GAM). A two-piecewise linear regression model was then applied, and a log-likelihood ratio test was used to compare the piecewise model to a single-linear-term model. Sensitivity analyses were conducted to check the robustness of the findings. RESULTS: The mean age of pregnant and postpartum women was 28.88 (95% CI 28.34-29.42) years. Overall, 7.1% participants met the criteria for moderate/severe depression (PHQ-9 score >/=10). DII scores ranged from anti-inflammatory to proinflammatory; approximately 21.9% of the sample had a highly proinflammatory diet (DII > 2.87). We observed a non-linear association between DII and depression (P for non-linearity = 0.008 for the threshold effect). In adjusted weighted logistic models, among women with DII > 2.87, each 1-unit increase in DII was associated with an OR = 2.81 for depression (95% confidence interval 1.07-7.38, p = 0.039). Consistently, in the weighted linear regression, when the DII exceeded 2.87, each additional DII point corresponded to an increase of beta = 1.59 points in the PHQ-9 score (95% CI 0.02-3.17, p = 0.047), indicating worse depressive symptom severity with more proinflammatory diets. The associations remained significant and of similar magnitude in the sensitivity analyses. CONCLUSION: In this cross-sectional study of pregnant and postpartum women in the U. S., a higher Dietary Inflammatory Index was associated with a greater risk of depression, but this relationship was markedly non-linear. Diets with very high proinflammatory potential were linked to significantly increased odds of perinatal depression, whereas more anti-inflammatory diets did not result in a further decrease in depression risk below that threshold. However, owing to the inherent limitations of the study design, causality cannot be established, and a reverse effect of depressive symptoms on dietary choice cannot be ruled out. CI - Copyright (c) 2025 Qiao, Han, Qu and Zhang. FAU - Qiao, Jian AU - Qiao J AD - Psychiatry Department, Jinan Mental Health Center, Jinan, China. FAU - Han, Aiqing AU - Han A AD - Department of Obstetrics and Gynecology, Jinan Maternity and Child Care Hospital, Jinan, China. FAU - Qu, Yannv AU - Qu Y AD - Geriatrics Department, Peking University Shenzhen Hospital, Shenzhen Peking University-The Hong Kong University of Science and Technology Medical Center, Shenzhen, China. AD - Shenzhen University, Shenzhen, China. FAU - Zhang, Li AU - Zhang L AD - Department of Obstetrics and Gynecology, Jinan Maternity and Child Care Hospital, Jinan, China. LA - eng PT - Journal Article DEP - 20251127 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12695599 OTO - NOTNLM OT - Dietary Inflammatory Index (DII) OT - PHQ-9 OT - depression OT - perinatal OT - postpartum women OT - pregnant women COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/15 13:10 MHDA- 2025/12/15 13:11 PMCR- 2025/11/27 CRDT- 2025/12/15 06:13 PHST- 2025/08/07 00:00 [received] PHST- 2025/11/09 00:00 [revised] PHST- 2025/11/14 00:00 [accepted] PHST- 2025/12/15 13:11 [medline] PHST- 2025/12/15 13:10 [pubmed] PHST- 2025/12/15 06:13 [entrez] PHST- 2025/11/27 00:00 [pmc-release] AID - 10.3389/fnut.2025.1681491 [doi] PST - epublish SO - Front Nutr. 2025 Nov 27;12:1681491. doi: 10.3389/fnut.2025.1681491. eCollection 2025. PMID- 41393747 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251215 LR - 20251217 IS - 2168-8184 (Print) IS - 2168-8184 (Electronic) IS - 2168-8184 (Linking) VI - 17 IP - 11 DP - 2025 Nov TI - When Formulas Fail: A Secondary Analysis of Dual-Energy X-ray Absorptiometry (DXA) Body Composition Data Comparing Ideal and Lean Body Weight Equations Against Measured Lean Body Weight in Obese Children. PG - e96759 LID - 10.7759/cureus.96759 [doi] LID - e96759 AB - Background Accurate weight-based drug dosing in obese children is essential for safe and effective therapy, yet the relationships between ideal body weight (IBW), lean body weight (LBW), and actual body composition remain poorly defined. IBW was originally developed to assess nutritional status rather than guide drug dosing, but it is often used as a surrogate for LBW despite limited validation. This study aimed to compare commonly used IBW and LBW formulas against measured LBW to evaluate their accuracy and clinical applicability in obese children. Methods A secondary analysis was conducted using data from 30 obese children (BMI-for-age Z-score >/=2.0) obtained in a hospital-based pediatric body composition study. Anthropometric data and dual-energy X-ray absorptiometry (DXA) measurements of LBW were available. Seven published equations for IBW and LBW estimation were evaluated. Accuracy was assessed using mean percentage error, root mean square percentage error, and proportions of estimates within 10% (P10) and 20% (P20) of measured LBW. Results All IBW formulas substantially overestimated measured LBW, with mean biases ranging from 18% to 30%, and none achieved acceptable accuracy (P10 <70%). Among LBW equations, the Foster formula demonstrated the highest accuracy, while the Peters and Callaghan methods performed poorly. Adjusting IBW formulas with simple correction factors improved LBW prediction accuracy, though similar corrections were not feasible for the Peters and Callaghan methods. Conclusions IBW formulas cannot reliably substitute for LBW in obese children without modification. The Foster equation offers the best accuracy for LBW estimation, while the BMI(5)(0) IBW method shows potential for adaptation in clinical tools. Further validation of hybrid or adjusted models is required to optimize pediatric drug dosing safety. CI - Copyright (c) 2025, Wells et al. FAU - Wells, Mike AU - Wells M AD - Department of Emergency Medicine, Florida Atlantic University Charles E. Schmidt College of Medicine, Boca Raton, USA. FAU - Goldstein, Lara N AU - Goldstein LN AD - Department of Emergency Medicine, Memorial Healthcare System, Hollywood, USA. LA - eng PT - Journal Article DEP - 20251113 PL - United States TA - Cureus JT - Cureus JID - 101596737 PMC - PMC12701679 OTO - NOTNLM OT - foster formula OT - ideal body weight OT - lean body weight OT - mclaren formula OT - moore formula OT - pediatric weight estimation OT - peters formula COIS- Human subjects: Informed consent for treatment and open access publication was obtained or waived by all participants in this study. The Human Research Ethics Committee of the University of the Witwatersrand issued approval M1511107. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. EDAT- 2025/12/15 13:10 MHDA- 2025/12/15 13:11 PMCR- 2025/11/13 CRDT- 2025/12/15 06:11 PHST- 2025/11/13 00:00 [accepted] PHST- 2025/12/15 13:11 [medline] PHST- 2025/12/15 13:10 [pubmed] PHST- 2025/12/15 06:11 [entrez] PHST- 2025/11/13 00:00 [pmc-release] AID - 10.7759/cureus.96759 [doi] PST - epublish SO - Cureus. 2025 Nov 13;17(11):e96759. doi: 10.7759/cureus.96759. eCollection 2025 Nov. PMID- 41393132 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251215 LR - 20251217 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 12 DP - 2025 TI - Survey of evidence-based nursing practice readiness for scoliosis-specific rehabilitation exercise in orthopedic nurses. PG - 1649858 LID - 10.3389/fmed.2025.1649858 [doi] LID - 1649858 AB - OBJECTIVE: The purpose of this study was to investigate the status of the readiness of evidence-based practice programs for adolescent idiopathic scoliosis, identify the influencing factors that will be faced in the implementation process, and promote the transformation of evidence. METHODS: Investigate the readiness of evidence-based practice plan for adolescent scoliosis patients: clinic readiness evidence-based nursing assessment was conducted on nurses from the Department of Spine Surgery, Rehabilitation Medicine and Pediatric Department of Y City Hospital in China using the general information questionnaire and the evidence-based nursing practice readiness rating scale to evaluate the evidence-based practice readiness of the program of "special sports rehabilitation nursing for adolescent idiopathic scoliosis" to identify the possible influencing factors during the implementation process of the program. RESULT: In the survey assessing readiness for an evidence-based practice plan regarding scoliosis-specific rehabilitation exercises, 177 valid questionnaires were collected. The mean total score of the CREBNA scale was 135.39 +/- 12.75, with subscale scores of 54.08 +/- 5.34 for evidence, 39.51 +/- 4.09 for organizational environment, and 41.80 +/- 5.38 for facilitating factors. Individual item scores ranged from 3.45 to 4.98. Univariate analysis revealed statistically significant differences in CREBNA total scores based on participants' understanding of evidence-based nursing practices and their perceived necessity. Multiple linear stepwise regression analysis further identified the perceived necessity of evidence-based nursing practice as the primary factor influencing readiness for implementation. CONCLUSION: The results of the survey on the readiness of evidence-based nursing practice showed that the current evidence-based nursing practice preparation of nurses for rehabilitation exercise for adolescents with idiopathic scoliosis was good and feasible. However, the study was limited to samples drawn from tertiary hospitals in Y City. Future multi-center and longitudinal studies are warranted to validate and extend these findings. CLINICAL IMPLICATIONS: To investigate the readiness of nurses for the clinical practice of exercise rehabilitation for adolescent idiopathic scoliosis, so as to expand the evidence-based practice of adolescent rehabilitation nursing, enrich the content of special exercise rehabilitation nursing for adolescent idiopathic scoliosis in China, reduce the pain caused by surgical treatment to patients, and improve its clinical value, which is of great significance in promoting the good outcome of patients, providing reference for follow-up research, and updating relevant clinical practice guidelines in the future. Selection criteria and guiding programs are provided for reference. CI - Copyright (c) 2025 Li, Xu, Cheng, Shen, Li and Li. FAU - Li, Binglin AU - Li B AD - Department of Nursing, The Third People's Hospital of Henan Province, Zhengzhou, China. AD - Yanbian University, Yanji, Jilin, China. FAU - Xu, Ruiman AU - Xu R AD - School of Nursing, Changchun Medical College, Changchun, Jilin, China. FAU - Cheng, Shina AU - Cheng S AD - Department of Nursing, The Third People's Hospital of Henan Province, Zhengzhou, China. FAU - Shen, Mingkui AU - Shen M AD - Department of Nursing, The Third People's Hospital of Henan Province, Zhengzhou, China. FAU - Li, Meng AU - Li M AD - Department of Nursing, The Third People's Hospital of Henan Province, Zhengzhou, China. FAU - Li, Huawei AU - Li H AD - Department of Nursing, The Third People's Hospital of Henan Province, Zhengzhou, China. LA - eng PT - Journal Article DEP - 20251128 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC12698479 OTO - NOTNLM OT - adolescent idiopathic scoliosis OT - clinic readiness for evidence-based nursing assessment OT - evidence-based practice OT - readiness for evidence-based nursing practices OT - rehabilitation nursing COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/15 13:10 MHDA- 2025/12/15 13:11 PMCR- 2025/11/28 CRDT- 2025/12/15 06:07 PHST- 2025/07/24 00:00 [received] PHST- 2025/11/03 00:00 [revised] PHST- 2025/11/12 00:00 [accepted] PHST- 2025/12/15 13:11 [medline] PHST- 2025/12/15 13:10 [pubmed] PHST- 2025/12/15 06:07 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - 10.3389/fmed.2025.1649858 [doi] PST - epublish SO - Front Med (Lausanne). 2025 Nov 28;12:1649858. doi: 10.3389/fmed.2025.1649858. eCollection 2025. PMID- 41392861 OWN - NLM STAT- MEDLINE DCOM- 20251215 LR - 20251215 IS - 2040-1752 (Electronic) IS - 2040-1744 (Linking) VI - 16 DP - 2025 Dec 15 TI - Exploring the relationships between food insecurity, maternal stress, and maternal-infant health outcomes during the COVID-19 pandemic. PG - e47 LID - 10.1017/S2040174425100317 [doi] AB - The COVID-19 pandemic intensified food insecurity (FI) and stress for many pregnant individuals, which may have contributed to adverse fetal developmental programming. This study aimed to identify key social determinants of health associated with pandemic-related FI and stress, and their association with gestational weight gain (GWG) and newborn birth weight in a Canadian pregnant cohort. Data were collected retrospectively from 273 pregnant individuals who delivered infants in Canada during the pandemic (March 2020-March 2023). Validated questionnaires were used to assess FI and pandemic-related stress, and GWG and infant birth weight were self-reported. FI was experienced by 55.7% of the participants, while 33.7% and 19.7% reported heightened stress related to COVID-19 infection and pregnancy preparedness, respectively. Participants from food-secure and food-insecure households differed significantly in parental structure, age, sexual orientation, housing status, household income, number of children in the household and pregnancy planning (all p values < 0.01). Heightened stress for both pregnancy preparedness and COVID-19 infection was also significantly associated with these same factors (all p values < 0.05) but not for age and housing status. FI and heightened stress were not associated with GWG outside the recommended range. However, significantly higher likelihood of birth weight extremes was observed with heightened COVID-19 infection-related stress (OR, 95% CI 1.50, 1.05-2.12, p = 0.02) and pregnancy preparedness-related stress (1.60, 1.10-2.31, p = 0.01), but not with FI. These findings underscore the influence of psychosocial factors on FI and stress during pregnancy, which may negatively impact infant health outcomes during the pandemic. FAU - Kalembo, Landry AU - Kalembo L AUID- ORCID: 0009-0007-5085-6789 AD - Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, Canada. FAU - Bainbridge, Shannon AU - Bainbridge S AUID- ORCID: 0000-0002-8947-8152 AD - Interdisciplinary School of Health Sciences, University of Ottawa, Ottawa, Canada. AD - Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Canada. FAU - Fontaine-Bisson, Benedicte AU - Fontaine-Bisson B AUID- ORCID: 0000-0002-9697-1164 AD - School of Nutrition Sciences, https://ror.org/03c4mmv16University of Ottawa, Ottawa, Canada. AD - Hopital Montfort, https://ror.org/04z45pv75Institut du Savoir Montfort, Ottawa, Canada. LA - eng PT - Journal Article DEP - 20251215 PL - England TA - J Dev Orig Health Dis JT - Journal of developmental origins of health and disease JID - 101517692 SB - IM MH - Humans MH - Female MH - *COVID-19/epidemiology/psychology MH - *Food Insecurity MH - Pregnancy MH - Adult MH - *Stress, Psychological/epidemiology/psychology MH - Infant, Newborn MH - Canada/epidemiology MH - Retrospective Studies MH - SARS-CoV-2 MH - *Infant Health MH - Gestational Weight Gain MH - Maternal Health MH - Birth Weight MH - Pandemics OTO - NOTNLM OT - COVID-19 pandemic OT - Food insecurity OT - maternal and infant health outcomes OT - pregnancy OT - stress EDAT- 2025/12/15 06:28 MHDA- 2025/12/15 06:29 CRDT- 2025/12/15 04:53 PHST- 2025/12/15 06:29 [medline] PHST- 2025/12/15 06:28 [pubmed] PHST- 2025/12/15 04:53 [entrez] AID - S2040174425100317 [pii] AID - 10.1017/S2040174425100317 [doi] PST - epublish SO - J Dev Orig Health Dis. 2025 Dec 15;16:e47. doi: 10.1017/S2040174425100317. PMID- 41392119 OWN - NLM STAT- MEDLINE DCOM- 20260120 LR - 20260123 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2025 Dec 15 TI - Global diet quality score (GDQS) favorably affects blood pressure, serum lipids, lipid accumulation product and attenuates inflammation among obese individuals. PG - 2569 LID - 10.1038/s41598-025-32538-1 [doi] LID - 2569 AB - The Global Diet Quality Score (GDQS) is a recently developed food-based index that evaluates both healthy and unhealthy dietary components and has been linked to non-communicable disease risk. However, limited evidence exists regarding its relationship with metabolic and inflammatory markers among obese individuals. This study aimed to examine the association between GDQS and cardio-metabolic risk factors, lipid accumulation product (LAP), and systemic inflammation in obese adults. In this cross-sectional study, 302 obese participants (body mass index [BMI] >/= 30 kg/m(2)) aged 18-50 years were recruited. Dietary intake was assessed using a validated food frequency questionnaire, and GDQS was calculated from 25 food groups. Anthropometric indices, blood pressure, fasting blood glucose, lipid profile, hemoglobin (Hb) A1c, insulin, homeostasis model assessment of insulin resistance (HOMA-IR), high sensitive C-reactive protein (hs-CRP), and LAP were measured. Participants were classified into tertiles of GDQS, and differences in metabolic parameters across tertiles were analyzed using analysis of covariance and multinomial regression models, adjusting for potential confounders. Higher GDQS tertiles were associated with significantly lower systolic blood pressure (P = 0.048), total cholesterol, triglycerides (both P < 0.05), hs-CRP (P < 0.001), and LAP (P = 0.026). No significant associations were observed between GDQS and other parameters. Greater adherence to a high-quality diet, as reflected by GDQS, is linked to favorable lipid profiles, reduced inflammation, and lower LAP in obese adults. These findings support the GDQS as a valuable tool for assessing diet quality and highlight the importance of dietary improvement in managing obesity-related metabolic risk. CI - (c) 2025. The Author(s). FAU - El-Sehrawy, Amr Ali Mohamed Abdelgawwad AU - El-Sehrawy AAMA AD - Department of Internal Medicine, Diabetes, Endocrinology and Metabolism, Mansoura University, Mansoura, Egypt. FAU - Mohammad, Suleiman Ibrahim AU - Mohammad SI AD - Electronic Marketing and Social Media, Economic and Administrative Sciences Zarqa University, Zarqa, Jordan. AD - Research follower, INTI International University, 71800, Nilai, Negeri Sembilan, Malaysia. FAU - Hussain, Wan Mohd Hirwani Wan AU - Hussain WMHW AD - Graduate School of Business, Universiti Kebangsaan Malaysia, 43600, Bangi, Selangor, Malaysia. FAU - Prasad, K D V AU - Prasad KDV AD - Symbiosis Institute of Business Management, Hyderabad, Symbiosis International (Deemed University), Pune, India. FAU - Vasudevan, Asokan AU - Vasudevan A AD - Faculty of Business and Communications, INTI International University, 71800, Nilai, Negeri Sembilan, Malaysia. AD - Shinawatra University, 99 Moo 10, Bangtoey, Samkhok, Pathum Thani, 12160, Thailand. FAU - Maashi, Marwah Suliman AU - Maashi MS AD - Medical Laboratory Sciences Department, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia. AD - Regenerative Medicine Unit, King Fahd Medical Research Centre, King Abdulaziz University, Jeddah, 21589, Saudi Arabia. FAU - Hsu, Chou-Yi AU - Hsu CY AD - Department of Pharmacy, Chia Nan University of Pharmacy and Science, Tainan, 71710, Taiwan. t545316@gmail.com. FAU - Al-Khafaji, Zahraa Khudhair Abbas AU - Al-Khafaji ZKA AD - College of pharmacy, the Islamic University, Najaf, Iraq. AD - Department of medical analysis, Medical laboratory technique college, the Islamic University of Al Diwaniyah, Al Diwaniyah, Iraq. FAU - Al-Mashhadani, Zuhair I AU - Al-Mashhadani ZI AD - Department of Medical Laboratories Technology, AL-Nisour University College, Baghdad, Iraq. FAU - Jafarzadeh, Faria AU - Jafarzadeh F AD - Department of Internal Medicine, North Khorasan University of Medical Sciences, Bojnourd, Iran. f.jafarzadeh@nkums.ac.ir. LA - eng PT - Journal Article DEP - 20251215 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Lipids) RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - Humans MH - *Obesity/blood/physiopathology MH - Adult MH - Female MH - Male MH - *Blood Pressure MH - Middle Aged MH - *Inflammation/blood MH - *Lipids/blood MH - Adolescent MH - Young Adult MH - Cross-Sectional Studies MH - *Diet MH - *Lipid Accumulation Product MH - Body Mass Index MH - C-Reactive Protein/metabolism PMC - PMC12819469 OTO - NOTNLM OT - GDQS OT - Global diet quality score OT - Inflammation OT - Metabolic profile OT - Obesity COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics approval and consent to participate: The current work has been ethically approved by the UKM-GSB, grant number GSB-2025-007 funded by the Graduate School of Business, UKM. The work was performed under guidelines of declaration of Helsinki and all of the subjects had signed the written informed consent before participation in the study. Consent for publication: Not applicable. EDAT- 2025/12/15 00:28 MHDA- 2026/01/21 01:48 PMCR- 2025/12/15 CRDT- 2025/12/14 23:10 PHST- 2025/09/28 00:00 [received] PHST- 2025/12/10 00:00 [accepted] PHST- 2026/01/21 01:48 [medline] PHST- 2025/12/15 00:28 [pubmed] PHST- 2025/12/14 23:10 [entrez] PHST- 2025/12/15 00:00 [pmc-release] AID - 10.1038/s41598-025-32538-1 [pii] AID - 32538 [pii] AID - 10.1038/s41598-025-32538-1 [doi] PST - epublish SO - Sci Rep. 2025 Dec 15;16(1):2569. doi: 10.1038/s41598-025-32538-1. PMID- 41391916 OWN - NLM STAT- MEDLINE DCOM- 20260312 LR - 20261019 IS - 1556-8342 (Electronic) IS - 1556-8253 (Linking) VI - 21 IP - 3 DP - 2026 Mar TI - Effectiveness of Combining LATCH and Bristol Breastfeeding Assessment Scales in Predicting Exclusive Breastfeeding. PG - 202-208 LID - 10.1177/15568253251404483 [doi] AB - BACKGROUND: Early identification of breastfeeding difficulties is crucial for targeted interventions. However, the comparative effectiveness of these assessment tools remains unclear. OBJECTIVE: To compare the predictive validity of the LATCH and Bristol Breastfeeding Assessment Tool (BBAT) scores measured at 24 hours and day 7 postpartum for exclusive breastfeeding at 42 days and to evaluate their combined predictive performance. METHODS: This prospective cohort study included 157 mother-infant dyads (September 2024-March 2025) at a university hospital in Turkey. LATCH and BBAT scores were assessed at 24 hours and on day 7 postpartum. The primary outcome was exclusive breastfeeding at 42 days. Receiver operating characteristic (ROC) analysis was used to determine the optimal cut-off values and predictive performance. RESULTS: The rate of exclusive breastfeeding (EBF) was 83.4% (n = 132) in the first 24 hours and 68.8% (n = 108) on day 42 of life. The LATCH score in the first week showed the highest specificity for predicting EBF on day 42. (cut-off value >/=10: area under the curve [AUC] 0.671 (95% CI: 0.582-0.760; p < 0.001), sensitivity 55.6%, specificity 72.3%, false positive rate 27.7%). A multiple ROC analysis was conducted to determine which of the four scores was better at predicting EBF on the 42nd day. The cutoff values were 8 for the first-week Bristol score alone, 10 for the first-week LATCH score, 5 for the first 24-hour Bristol score, and 7 for the first 24-hour LATCH score. CONCLUSIONS: Combined early assessment using LATCH and BBAT scores provides a superior prediction of EBF at 42 days compared with single indicators. The implementation of systematic screening using these tools may facilitate targeted lactation support for at-risk dyads. FAU - Livaoglu Say, Birgul AU - Livaoglu Say B AD - Pediatrics Department, Alanya Alaaddin Keykubat University, Alanya, Turkey. FAU - Kaya, Fatma Erva AU - Kaya FE AD - Pediatrics Department, Alanya Alaaddin Keykubat University, Alanya, Turkey. FAU - Hatipoglu, Halil Ugur AU - Hatipoglu HU AD - Department of Child Health and Diseases, Istanbul Haseki Health Application and Research Center, Hamidiye Medical Faculty of Health Sciences University, Alanya, Turkey. LA - eng PT - Journal Article DEP - 20251218 PL - United States TA - Breastfeed Med JT - Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine JID - 101260777 SB - IM MH - Humans MH - *Breast Feeding/statistics & numerical data/psychology MH - Female MH - Adult MH - Prospective Studies MH - Turkey MH - Infant, Newborn MH - ROC Curve MH - *Mothers/psychology MH - Infant MH - Predictive Value of Tests MH - Surveys and Questionnaires MH - Reproducibility of Results MH - Postpartum Period OTO - NOTNLM OT - Bristol Breastfeeding Assessment Tool OT - LATCH score OT - assessment scales OT - breastfeeding OT - exclusive breastfeeding COIS- Author Disclosure StatementNone declared. EDAT- 2025/12/15 00:28 MHDA- 2026/03/12 07:04 CRDT- 2025/12/14 20:53 PHST- 2026/03/12 07:04 [medline] PHST- 2025/12/15 00:28 [pubmed] PHST- 2025/12/14 20:53 [entrez] AID - 10.1177/15568253251404483 [doi] PST - ppublish SO - Breastfeed Med. 2026 Mar;21(3):202-208. doi: 10.1177/15568253251404483. Epub 2025 Dec 18. PMID- 41391732 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20260803 IS - 1878-5921 (Electronic) IS - 0895-4356 (Linking) VI - 191 DP - 2026 Mar TI - Factors influencing use and choice of Core Outcome Sets and Outcome Measurement Instruments in trials of interventions to prevent childhood obesity: a mixed-methods survey. PG - 112105 LID - S0895-4356(25)00438-X [pii] LID - 10.1016/j.jclinepi.2025.112105 [doi] AB - BACKGROUND AND OBJECTIVE: Heterogeneity in what and how outcomes are measured in childhood obesity prevention trials limits evidence synthesis and evaluation of intervention effectiveness. Core Outcome Sets (COS) and Core Outcome Measurement Sets (COMS) can standardize measurement and reporting across trials, but only if they are used by trialists. This study examined trialists' awareness and attitudes toward two childhood obesity-related COS and factors influencing their use; characteristics of Outcome Measurement Instruments (OMIs) used in childhood obesity prevention trials; and how trialists choose these OMIs. METHODS: An online, international, cross-sectional survey was conducted including trialists engaged in designing and/or conducting childhood obesity prevention trials in children aged 0-5 years. Trialists were recruited via peer-reviewed publications, the Transforming Obesity Prevention for CHILDren Collaboration and professional contacts. The survey examined trialist characteristics, awareness, and use of existing COS, OMI characteristics, and factors influencing trialist selection of OMIs. Quantitative data were analyzed descriptively; qualitative data were analyzed using content analysis. RESULTS: The majority of the 46 trialists who completed the survey were senior-career researchers (61%; n = 28), with 1 to 38 years' experience in childhood obesity prevention trials. Seventy percent (n = 32) were familiar with COS in general; 84% (n = 26) of these were familiar with one or both childhood obesity-related COS. These trialists' COS use was limited by perceived participant burden, cost, and lack of knowledge; availability of guidelines, and resources facilitated COS use. Trialists favored measuring outcomes using existing (83%; n = 38) and adapted (80%; n = 37) questionnaires, and anthropometric measures (80%; n = 37). Quantitative and qualitative data indicated that measurement properties (eg, reliability, validity), cost, perceived burden, ease of use, and feasibility were the most important factors influencing trialists' OMI choice. CONCLUSION: Trialists' awareness and use of childhood obesity-related COS is positive, and may be enhanced through provision of guidance and resources to support COS and COMS use. Development of COMS should consider trialist-reported factors related to feasibility and measurement properties. Such considerations can enhance COS and COMS use in trials, reducing outcome heterogeneity, and improving evaluation of intervention effectiveness to prevent childhood obesity. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Looney, Eibhlin AU - Looney E AD - School of Public Health, University College Cork, Cork, County Cork, Ireland. FAU - Duffy, Moira AU - Duffy M AD - School of Public Health, University College Cork, Cork, County Cork, Ireland. FAU - Dutch, Dimity AU - Dutch D AD - School of Public Health, University College Cork, Cork, County Cork, Ireland; Flinders University, College of Nursing and Health Sciences, Caring Futures Institute, Adelaide, South Australia, Australia. FAU - Brown, Victoria AU - Brown V AD - Deakin Health Economics, Institute for Health Transformation, Deakin University, Geelong, Australia. FAU - Browne, John AU - Browne J AD - School of Public Health, University College Cork, Cork, County Cork, Ireland. FAU - Devane, Declan AU - Devane D AD - HRB Trials Methodology Research Network, and Evidence Synthesis Ireland and Cochrane Ireland, School of Nursing and Midwifery, University of Galway, Galway, County Galway, Ireland. FAU - Harrington, Janas M AU - Harrington JM AD - School of Public Health, University College Cork, Cork, County Cork, Ireland. FAU - Hayes, Catherine AU - Hayes C AD - Public Health & Primary Care, School of Medicine, The University of Dublin Trinity College, Dublin, Ireland. FAU - Johnson, Brittany J AU - Johnson BJ AD - Flinders University, College of Nursing and Health Sciences, Caring Futures Institute, Adelaide, South Australia, Australia. FAU - Kearney, Patricia M AU - Kearney PM AD - School of Public Health, University College Cork, Cork, County Cork, Ireland. FAU - Kirkham, Jamie J AU - Kirkham JJ AD - Centre for Biostatistics, The University of Manchester, Manchester Academic Health Service Centre, Manchester, England. FAU - Leahy-Warren, Patricia AU - Leahy-Warren P AD - School of Nursing and Midwifery, University College Cork, Cork, County Cork, Ireland. FAU - Murphy, Andrew W AU - Murphy AW AD - HRB Primary Care Clinical Trials Network Ireland, University of Galway, Galway, County Galway, Ireland. FAU - Redsell, Sarah AU - Redsell S AD - School of Health Sciences, University of Nottingham, Nottingham, UK. FAU - Seidler, Anna Lene AU - Seidler AL AD - Department of Child and Adolescent Psychiatry, University Medical Centre Rostock, Rostock, Germany; German Center for Child and Adolescent Health (DZKJ), Partner Site Greifswald/Rostock, Rostock, Germany. FAU - Skouteris, Helen AU - Skouteris H AD - School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia. FAU - Dahly, Darren AU - Dahly D AD - HRB Clinical Research Facility Cork, School of Public Health, University College Cork, Cork, County Cork, Ireland. FAU - Matvienko-Sikar, Karen AU - Matvienko-Sikar K AD - School of Public Health, University College Cork, Cork, County Cork, Ireland. Electronic address: karen.msikar@ucc.ie. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251212 PL - United States TA - J Clin Epidemiol JT - Journal of clinical epidemiology JID - 8801383 SB - IM MH - Humans MH - *Pediatric Obesity/prevention & control MH - Cross-Sectional Studies MH - Child, Preschool MH - Male MH - Female MH - *Outcome Assessment, Health Care/methods/statistics & numerical data MH - Surveys and Questionnaires MH - Infant MH - Adult MH - Infant, Newborn OTO - NOTNLM OT - Child health behaviors OT - Childhood obesity OT - Core outcome measurement sets OT - Core outcome set OT - Outcome measurement instrument OT - Trialists COIS- Declaration of competing interest There are no competing interests for any author. EDAT- 2025/12/15 00:28 MHDA- 2026/03/07 18:38 CRDT- 2025/12/14 19:39 PHST- 2025/07/22 00:00 [received] PHST- 2025/12/02 00:00 [revised] PHST- 2025/12/08 00:00 [accepted] PHST- 2026/03/07 18:38 [medline] PHST- 2025/12/15 00:28 [pubmed] PHST- 2025/12/14 19:39 [entrez] AID - S0895-4356(25)00438-X [pii] AID - 10.1016/j.jclinepi.2025.112105 [doi] PST - ppublish SO - J Clin Epidemiol. 2026 Mar;191:112105. doi: 10.1016/j.jclinepi.2025.112105. Epub 2025 Dec 12. PMID- 41391202 OWN - NLM STAT- MEDLINE DCOM- 20260125 LR - 20260218 IS - 1472-6491 (Electronic) IS - 1472-6483 (Linking) VI - 52 IP - 1 DP - 2026 Jan TI - Fast and furious: live birth outcomes in 1266 infants born after one-step warming of vitrified human blastocysts. PG - 105238 LID - S1472-6483(25)00445-6 [pii] LID - 10.1016/j.rbmo.2025.105238 [doi] AB - RESEARCH QUESTION: Does one-step rehydration in the warming protocol for human blastocysts result in healthy live births? DESIGN: A total of 2411 frozen embryo transfers using a short one-step rehydration protocol and 2606 frozen embryo transfers using the multi-step protocol were available for analysis. One-step warming was performed at 37 degrees C in 1M sucrose for 1 min. This study examined the gestational age at delivery and birth weight of male and female infants for both protocols. RESULTS: In the one-step warming protocol, 1266 infants were born. The overall live birth rate was 51.3%, average gestational age was 37.6 weeks, and average birth weight was 3267 g. The sex distribution was 49% male versus 51% female. Male infants were, on average, 70 g heavier than female infants (3305 g versus 3235 g, respectively). In the multi-step warming protocol, 1323 infants were born. The average gestational age was 37.6 weeks, and average birth weight was 3252 g. The sex distribution was 52% male versus 48% female. Male infants were, on average, 139 g heavier than female infants (3318 g vs 3179 g, respectively). There were no significant differences between the two warming groups in terms of live birth and miscarriage rates, gestational age and birth weight. CONCLUSIONS: Short one-step rehydration during warming of human blastocysts for 1 min in 1M sucrose led to healthy infants born at term with corresponding birth weight. This one-step rehydration protocol has been shown to be safe and effective, and it has now been validated with 1266 live births. CI - Copyright (c) 2025 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved. FAU - Liebermann, Juergen AU - Liebermann J AD - Fertility Centers of Illinois - US Fertility, Chicago, IL, USA. Electronic address: juergen.liebermann@fcionline.com. FAU - Brohammer, Rebecca AU - Brohammer R AD - Fertility Centers of Illinois - US Fertility, Chicago, IL, USA. FAU - Wagner, Yuri AU - Wagner Y AD - Fertility Centers of Illinois - US Fertility, Chicago, IL, USA. FAU - Parus, Allison AU - Parus A AD - Fertility Centers of Illinois - US Fertility, Chicago, IL, USA. FAU - Macias, Cynthia AU - Macias C AD - Fertility Centers of Illinois - US Fertility, Chicago, IL, USA. FAU - Suda, Nivek AU - Suda N AD - Fertility Centers of Illinois - US Fertility, Chicago, IL, USA. FAU - Vanderpool, Alexis AU - Vanderpool A AD - Fertility Centers of Illinois - US Fertility, Chicago, IL, USA. FAU - Petrus, Gabija AU - Petrus G AD - Fertility Centers of Illinois - US Fertility, Chicago, IL, USA. FAU - Sarris, Olivia AU - Sarris O AD - Fertility Centers of Illinois - US Fertility, Chicago, IL, USA. FAU - Even, Kelly AU - Even K AD - Fertility Centers of Illinois - US Fertility, Chicago, IL, USA. FAU - Smith, Ru AU - Smith R AD - Fertility Centers of Illinois - US Fertility, Chicago, IL, USA. FAU - Sutherland, Shelby AU - Sutherland S AD - Fertility Centers of Illinois - US Fertility, Chicago, IL, USA. FAU - Jasulaitis, Sue AU - Jasulaitis S AD - Fertility Centers of Illinois - US Fertility, Chicago, IL, USA. FAU - Hirshfeld-Cytron, Jennifer AU - Hirshfeld-Cytron J AD - Fertility Centers of Illinois - US Fertility, Chicago, IL, USA. FAU - Sipe, Christopher AU - Sipe C AD - Fertility Centers of Illinois - US Fertility, Chicago, IL, USA. FAU - Uhler, Meike AU - Uhler M AD - Fertility Centers of Illinois - US Fertility, Chicago, IL, USA. LA - eng PT - Journal Article DEP - 20250831 PL - Netherlands TA - Reprod Biomed Online JT - Reproductive biomedicine online JID - 101122473 SB - IM MH - Humans MH - Female MH - Male MH - Pregnancy MH - *Live Birth MH - Infant, Newborn MH - *Embryo Transfer/methods MH - Vitrification MH - *Blastocyst MH - Birth Weight MH - Adult MH - *Cryopreservation/methods MH - Gestational Age MH - Pregnancy Outcome OTO - NOTNLM OT - Birth weight OT - Blastocysts OT - Gestational age OT - Live births OT - Multi-step warming OT - One-step warming EDAT- 2025/12/14 19:19 MHDA- 2026/01/26 00:33 CRDT- 2025/12/14 18:01 PHST- 2025/06/10 00:00 [received] PHST- 2025/08/28 00:00 [revised] PHST- 2025/08/28 00:00 [accepted] PHST- 2026/01/26 00:33 [medline] PHST- 2025/12/14 19:19 [pubmed] PHST- 2025/12/14 18:01 [entrez] AID - S1472-6483(25)00445-6 [pii] AID - 10.1016/j.rbmo.2025.105238 [doi] PST - ppublish SO - Reprod Biomed Online. 2026 Jan;52(1):105238. doi: 10.1016/j.rbmo.2025.105238. Epub 2025 Aug 31. PMID- 41391087 OWN - NLM STAT- MEDLINE DCOM- 20251214 LR - 20251231 IS - 0004-5772 (Print) IS - 0004-5772 (Linking) VI - 73 IP - 12 DP - 2025 Dec TI - The Interplay of Age, Obesity Measures, and Micronutrient Deficiencies in PCOS-associated Metabolic Dysfunction Findings from a Retrospective Postobservational Cohort Study. PG - e8-e16 LID - 10.59556/japi.73.1281 [doi] AB - BACKGROUND: Polycystic ovary syndrome (PCOS) is a complex endocrine-metabolic disorder with significant age-related, anthropometric, and metabolic variations. Understanding the interplay between age, body composition, and micronutrient status can help identify predictors of metabolic dysfunction and long-term complications in women with PCOS. Most studies assess these factors in isolation, resulting in fragmented evidence and inconsistent conclusions. OBJECTIVES: This study aimed to evaluate the predictive associations of age, anthropometric parameters, and micronutrient levels (vitamin B12 and vitamin D3) with key metabolic, cardiovascular, and nutritional markers in women diagnosed with PCOS. MATERIALS AND METHODS: A cross-sectional analysis was conducted among women with PCOS, divided into two age-groups: group I (15-30 years) and group II (31-40 years). One-way analysis of variance (ANOVA) and linear regression analyses were performed to investigate age- and obesity-related differences in metabolic parameters. Pearson's correlations and regression models were applied to assess the predictive strength of age, body mass index (BMI), waist circumference (WC), vitamin B12, and vitamin D3 on metabolic outcomes. The Benjamini-Hochberg method was applied to control the false discovery rate (FDR) for multiple comparisons and ensure conclusions account for the increased risk of type I error due to multiple comparisons, thereby supporting the validity of the study's observations. RESULTS: The PCOS cohort exhibited generalized overweight (BMI 23.0-24.9 kg/m(2)) and obesity (BMI >/=25.0 kg/m(2)) in 40 and 54% of subjects, respectively; notably, visceral obesity (WC >/=80 cm) was present in 97% of the cohort, underscoring a marked predominance of central adiposity even among those with lower BMI thresholds. The PCOS cohort demonstrated high metabolic risk, with frequent insulin resistance, dyslipidemia, and hypertension; notably, 25% had nonalcoholic fatty liver disease (NAFLD), predominantly mild steatosis, indicating a substantial risk for future cardiometabolic complications. Advancing age was significantly associated with higher fasting blood sugar (FBS) (p = 0.019) and glycated hemoglobin (HbA1c) (p = 0.048), while fasting insulin declined with age (p = 0.048). BMI and WC were strong predictors of metabolic risk, positively impacting fasting insulin, FBS, HbA1c, and blood pressure (p < 0.05), while showing significant negative associations with high-density lipoprotein cholesterol (HDL-C) (p < 0.001). Vitamin B12 and D3 levels showed no significant impact on metabolic parameters. Vitamin B12 was predicted only by age (p < 0.001) and vitamin D3 (p < 0.001), while vitamin D3 was influenced by age (p < 0.001) and vitamin B12 levels (p = 0.041). CONCLUSION: Central obesity markers-particularly WC and BMI-are robust predictors of metabolic dysfunction in PCOS, offering greater prognostic value than micronutrient levels such as vitamin B12 or D3, which showed limited association with metabolic disturbances in this population. These findings highlight the primacy of early detection and intervention targeting adiposity and insulin resistance to reduce long-term cardiometabolic risk among women with PCOS. Integrated, multifactorial risk assessment remains essential, as age, nutritional deficits, and obesity-related factors independently and collectively drive adverse metabolic outcomes in PCOS, emphasizing the need for comprehensive preventive and management strategies. CI - (c) Journal of The Association of Physicians of India 2025. FAU - Tumbi, Zubeda AU - Tumbi Z AD - Founder and Director, Department of Clinical Dietetics, HealthWatch Nutrition Clinic, Mumbai, Maharashtra, India, Orcid: https://orcid.org/0009-0004-4915-3136, Corresponding Author. FAU - Tumbi, Mehzamah AU - Tumbi M AD - Assistant Dietitian, Department of Clinical Nutrition and Dietetics, HealthWatch Nutrition Clinic, Mumbai, Maharashtra, India. FAU - Tailor, Vaibhavi AU - Tailor V AD - Assistant Dietitian, Department of Clinical Nutrition and Dietetics, HealthWatch Nutrition Clinic, Mumbai, Maharashtra, India. FAU - Temkar, Gunjan AU - Temkar G AD - Research Assistant, Department of Information and Technology, HealthWatch Nutrition Clinic, Mumbai, Maharashtra, India. LA - eng PT - Journal Article PT - Observational Study PL - India TA - J Assoc Physicians India JT - The Journal of the Association of Physicians of India JID - 7505585 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Female MH - Adult MH - *Polycystic Ovary Syndrome/complications/metabolism MH - Young Adult MH - Cross-Sectional Studies MH - Retrospective Studies MH - *Obesity/complications/epidemiology MH - Adolescent MH - Body Mass Index MH - *Micronutrients/deficiency MH - Age Factors MH - Waist Circumference EDAT- 2025/12/14 15:52 MHDA- 2025/12/14 15:53 CRDT- 2025/12/14 11:22 PHST- 2025/12/14 15:53 [medline] PHST- 2025/12/14 15:52 [pubmed] PHST- 2025/12/14 11:22 [entrez] AID - 10.59556/japi.73.1281 [doi] PST - ppublish SO - J Assoc Physicians India. 2025 Dec;73(12):e8-e16. doi: 10.59556/japi.73.1281. PMID- 41390639 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2025 Dec 13 TI - Variation in real world dementia risk profiles according to demographic characteristics in 6171 adults drawn from the Australian CogDrisk website. PG - 233 LID - 10.1186/s12889-025-25943-8 [doi] LID - 233 AB - BACKGROUND: We aimed to evaluate differences in dementia risk profiles according to age, birthplace and First Nations status. METHODS: The sample included 6171 (62% female, < 1% non-binary/other) middle-aged and older adults who self-administered the CogDrisk assessment online and consented to their data being used for research from May 2023 to May 2024. The majority were aged 40-64 ('midlife'; 67.9%) or aged 65-96 ('later-life'; 25.8%); 6.3% were aged 18-40. More than a third (36.2%) were born overseas, 95% resided in Australia, and 66.0% had a university degree. RESULTS: Key midlife risk factors were hypertension 27.7%, pesticide exposure 24.6%, high cholesterol 25.1%, head injury 15.3%, diabetes 7.6%, and atrial fibrillation (AFib) 7.3%. Key later-life risk factors were hypertension 45.4%, pesticide exposure 33.0%, AFib 18.3% head injury 16.4%, and diabetes 11.7%. Midlife respondents born in the Pacific and New Zealand (NZ) had high rates of vascular risk factors and those born in NZ reported high rates of head injury and depression. The highest rates of heavy drinking and insufficient physical activity were reported by respondents born in the UK and Asia respectively. Using published estimates from validation studies, 20% of those aged 65 + had a high dementia risk (CogDrisk score > 12). CONCLUSIONS: High rates of multiple risk factors were identified and varied according to age group and birthplace. This study provides evidence for tailoring risk reduction intervention and advice by age and birthplace. FAU - Anstey, Kaarin J AU - Anstey KJ AD - School of Psychology, University of New South Wales, Kensington, NSW, 2052, Australia. k.anstey@unsw.edu.au. AD - Neuroscience Research Australia, Randwick, NSW, Australia. k.anstey@unsw.edu.au. AD - UNSW Ageing Futures Institute, University of New South Wales, Kensington, NSW, Australia. k.anstey@unsw.edu.au. FAU - Huque, Md Hamidul AU - Huque MH AD - School of Psychology, University of New South Wales, Kensington, NSW, 2052, Australia. AD - Neuroscience Research Australia, Randwick, NSW, Australia. AD - UNSW Ageing Futures Institute, University of New South Wales, Kensington, NSW, Australia. FAU - Eramudugolla, Ranmalee AU - Eramudugolla R AD - School of Psychology, University of New South Wales, Kensington, NSW, 2052, Australia. AD - Neuroscience Research Australia, Randwick, NSW, Australia. AD - UNSW Ageing Futures Institute, University of New South Wales, Kensington, NSW, Australia. FAU - Li, Meiwei AU - Li M AD - School of Psychology, University of New South Wales, Kensington, NSW, 2052, Australia. FAU - Long, Marita AU - Long M AD - Department of General Practice and Primary Care, University of Melbourne, Parkville, VIC, Australia. FAU - Kootar, Scherazad AU - Kootar S AD - Clinical Research Centre, The Sydney Children's Hospital Network, Westmead, NSW, Australia. FAU - Cartwright, Michael AU - Cartwright M AD - Neuroscience Research Australia, Randwick, NSW, Australia. FAU - O'Connor, Claire Mc AU - O'Connor CM AD - School of Psychology, University of New South Wales, Kensington, NSW, 2052, Australia. AD - Neuroscience Research Australia, Randwick, NSW, Australia. AD - Centre for Positive Ageing, HammondCare, Hammondville, NSW, Australia. FAU - Temple, Jeromey AU - Temple J AD - Melbourne School of Population and Global Health, University of Melbourne, Carlton, VIC, Australia. LA - eng GR - FL190100011/Australian Research Council/ PT - Journal Article DEP - 20251213 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - *Dementia/epidemiology/ethnology MH - Middle Aged MH - Australia/epidemiology MH - Risk Factors MH - Aged MH - Adult MH - Aged, 80 and over MH - Male MH - Young Adult MH - Adolescent MH - Risk Assessment MH - Age Factors PMC - PMC12821871 OTO - NOTNLM OT - Community setting OT - Country of birth OT - Dementia OT - Risk factors OT - Risk profiles COIS- Declarations. Ethics approval and consent to participate: Ethics approval is provided by the University of New South Wales Human Research Ethics Committee (UNSW HREC; protocol number HC200108). All data are de-identified and stored on a secure server at Neuroscience Research Australia. All the participants provided informed consent to the original data collection. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/14 00:39 MHDA- 2026/06/27 06:43 PMCR- 2025/12/13 CRDT- 2025/12/13 23:21 PHST- 2024/10/28 00:00 [received] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/06/27 06:43 [medline] PHST- 2025/12/14 00:39 [pubmed] PHST- 2025/12/13 23:21 [entrez] PHST- 2025/12/13 00:00 [pmc-release] AID - 10.1186/s12889-025-25943-8 [pii] AID - 25943 [pii] AID - 10.1186/s12889-025-25943-8 [doi] PST - epublish SO - BMC Public Health. 2025 Dec 13;26(1):233. doi: 10.1186/s12889-025-25943-8. PMID- 41390416 OWN - NLM STAT- MEDLINE DCOM- 20260120 LR - 20260123 IS - 1743-0003 (Electronic) IS - 1743-0003 (Linking) VI - 23 IP - 1 DP - 2025 Dec 13 TI - Overground robotic walker use in the home and community: a six-month prospective cohort study. PG - 22 LID - 10.1186/s12984-025-01812-8 [doi] LID - 22 AB - BACKGROUND: Outcomes following long-term use of overground robotic walkers have not been studied, even though children with mobility impairments are using these devices for extended periods. We aimed to evaluate the impacts of six months of overground robotic walker use in the home and community. METHODS: An observational cohort study was conducted with a volunteer sample of 171 participants with mobility impairments who privately obtained an overground robotic walker. Participant-initiated overground robotic walker use in the home and community was evaluated over six-months. The primary outcome of functional ability was assessed by parent report using the Gillette Functional Assessment Questionnaire (FAQ). Secondary outcome measures were parent-reported physical activity, positive affect, sleep disturbance, and bowel movement frequency. Questionnaires were sent digitally at baseline (when users received device use training), and then 1-Month, 3-Months and 6-Months later. The device tracked monthly usage, specifically number of steps, minutes of use, average cadence (steps/minute), and the number of times the device was used. RESULTS: Median participant age was 6 years (range 1 to 24), 42.1% were female, 70.8% had a diagnosis of cerebral palsy, and most were not independently ambulatory (97.3% of participants who reported function). Adjusted cumulative link mixed models demonstrated a significant main effect of time for FAQ scores, with increased log odds of a higher FAQ score at each time point (ss=0.86, 95% CI [0.25, 1.46], p = 0.006). The median FAQ score increased from 1 at baseline to 2 at subsequent time points. Adjusted repeated measures linear mixed-effects models demonstrated significant main effects of time for secondary outcomes, with improvements in physical activity scores (ss=0.96, 95% CI [0.21, 1.71], p = 0.012), sleep disturbance scores (ss=-0.82, 95% CI [-1.61, -0.04], p = 0.040), average cadence (steps/minute) (ss=1.86, 95% CI [0.61, 3.11], p = 0.004), and also decreases in the number of times the device was used per month (ss=-0.95, 95% CI [-1.63, -0.26], p = 0.007). Device usage time and total steps per month did not significantly change over time. CONCLUSIONS: Six months of overground robotic walker use resulted in modest, statistically significant improvements in functional ability and secondary outcomes linked to physical inactivity. Device usage time was consistent over time, suggesting feasibility of long-term home and community use. CI - (c) 2025. The Author(s). FAU - Hilderley, Alicia J AU - Hilderley AJ AD - Department of Pediatrics, University of Calgary, Calgary, AB, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. AD - Alberta Children's Hospital Research Institute, Calgary, AB, Canada. FAU - Diot, Christa M AU - Diot CM AD - Alberta Children's Hospital, Calgary, AB, Canada. FAU - Shen, Hua AU - Shen H AD - Department of Mathematics and Statistics, University of Calgary, Calgary, AB, Canada. FAU - Dukelow, Sean P AU - Dukelow SP AD - Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. AD - Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada. FAU - Larkin-Kaiser, Kelly A AU - Larkin-Kaiser KA AD - Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. AD - Alberta Children's Hospital Research Institute, Calgary, AB, Canada. AD - Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada. FAU - Kirton, Adam AU - Kirton A AD - Department of Pediatrics, University of Calgary, Calgary, AB, Canada. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. AD - Alberta Children's Hospital Research Institute, Calgary, AB, Canada. AD - Alberta Children's Hospital, Calgary, AB, Canada. FAU - Condliffe, Elizabeth G AU - Condliffe EG AD - Department of Pediatrics, University of Calgary, Calgary, AB, Canada. elizabeth.condliffe@ucalgary.ca. AD - Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada. elizabeth.condliffe@ucalgary.ca. AD - Alberta Children's Hospital Research Institute, Calgary, AB, Canada. elizabeth.condliffe@ucalgary.ca. AD - Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada. elizabeth.condliffe@ucalgary.ca. AD - Division of Physical Medicine & Rehabilitation, Departments of Clinical Neurosciences and Pediatrics, Alberta Children's Hospital Research Institute, Hotchkiss Brain Institute, University of Calgary , Calgary, Canada. elizabeth.condliffe@ucalgary.ca. LA - eng PT - Journal Article PT - Observational Study DEP - 20251213 PL - England TA - J Neuroeng Rehabil JT - Journal of neuroengineering and rehabilitation JID - 101232233 SB - IM MH - Humans MH - Female MH - Male MH - *Robotics MH - Prospective Studies MH - Child MH - *Walkers MH - Adolescent MH - Child, Preschool MH - Young Adult MH - Infant MH - Cohort Studies MH - Surveys and Questionnaires MH - Cerebral Palsy/rehabilitation PMC - PMC12817716 OTO - NOTNLM OT - Assistive device OT - Cerebral palsy OT - Patient reported outcome measures OT - Rehabilitation OT - Robotics COIS- Declarations. Ethics approval and consent to participate: The ethics committee of the University of Calgary (Calgary, Canada) approved the protocol (REB20-0799). Informed consent/assent was electronically obtained from participants/guardians. Consent for publication: Not applicable. Competing interests: This study received in-kind support from Trexo-Robotics but academic independence was protected as part of our Data Sharing Agreement. We have access to the raw usage data from Trexo-Robotics' QuickSite database. Trexo-Robotics included reminders to complete our questionnaires as part of their customer service "check-ins" and has been consulted as needed (e.g. factors that can cause non-use/missing data). Trexo-Robotics has seen preliminary presentations of this data in academic settings, but did not contribute to the data analysis, writing or editing of this manuscript. Dr. Condliffe's research program has received an unrestricted donation from Trexo Robotics and she is an unpaid member of the Clinical Advisory Board for Bionic Power who makes another robot-assisted walking aid. EDAT- 2025/12/14 00:39 MHDA- 2026/01/20 07:44 PMCR- 2025/12/13 CRDT- 2025/12/13 23:14 PHST- 2025/06/17 00:00 [received] PHST- 2025/11/15 00:00 [accepted] PHST- 2026/01/20 07:44 [medline] PHST- 2025/12/14 00:39 [pubmed] PHST- 2025/12/13 23:14 [entrez] PHST- 2025/12/13 00:00 [pmc-release] AID - 10.1186/s12984-025-01812-8 [pii] AID - 1812 [pii] AID - 10.1186/s12984-025-01812-8 [doi] PST - epublish SO - J Neuroeng Rehabil. 2025 Dec 13;23(1):22. doi: 10.1186/s12984-025-01812-8. PMID- 41390355 OWN - NLM STAT- MEDLINE DCOM- 20260211 LR - 20260530 IS - 1867-0687 (Electronic) IS - 1708-8569 (Print) VI - 22 IP - 1 DP - 2026 Jan TI - Final height prediction of girls at menarche: a combined model using left hand and wrist bone age, knee radiomic scores, and clinical characteristics. PG - 129-141 LID - 10.1007/s12519-025-01002-5 [doi] AB - BACKGROUND: Accurate final height prediction for girls with menarche is important, yet traditional Greulich-Pyle (GP) and Bayley-Pinneau predictions based on left hand-wrist bone age (BA) and target height demonstrate limited accuracy. This study aims to develop a method to more accurately predict final height. METHODS: One hundred and seventy-three girls with menarche from August 2018 to June 2023 were analyzed retrospectively. BAs in Greulich and Pyle and Hoerr knee atlases were evaluated. Knee radiomic features were extracted using PyRadiomics; least absolute shrinkage and selection operator regression was utilized to develop radiomic scores of the distal femur and proximal tibia. Ordinary least squares regression with stepwise selection was used to build a multilinear equation. This was further compared with traditional methods in fivefold cross-validation (CV = 5) using residual distribution and Bland-Altman agreement analysis. RESULTS: Height gain in our Chinese cohort after menarche was 8.94 +/- 2.99 cm. A stepwise multilinear equation was built with height at menarche, BA of GP and radiomic score of the distal femur (R(2) = 0.733, F statistic = 115.1, P < 0.05). Compared with traditional methods, a multilinear equation displayed the lowest residuals (residual range: - 5.677 cm to + 6.444 cm) and best Bland-Altman agreement (the mean difference: - 0.01 cm, 95% limits of agreement: - 3.96 to + 3.93 cm). CONCLUSIONS: A robust linear regression model that incorporates knee radiomic scores, BA of GP, height at menarche, and father's height demonstrated the best final height prediction in our cohort. This research is an innovative application of radiomic score of the distal femur to final height prediction. Further validation is warranted to test robustness across populations and scenarios. CI - (c) 2025. The Author(s). FAU - Xu, Xue-Qiong AU - Xu XQ AD - Department of Endocrinology, Genetics and Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Chen, Yao AU - Chen Y AD - Department of Endocrinology, Genetics and Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Wang, Yi-Rou AU - Wang YR AD - Department of Endocrinology, Genetics and Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Hu, Fei-Han AU - Hu FH AD - Department of Endocrinology, Genetics and Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Li, Juan AU - Li J AD - Department of Endocrinology, Genetics and Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Chang, Guo-Ying AU - Chang GY AD - Department of Endocrinology, Genetics and Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Li, Xin AU - Li X AD - Department of Endocrinology, Genetics and Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Wang, Rui AU - Wang R AD - Department of Cardiology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. FAU - Ding, Yu AU - Ding Y AD - Department of Endocrinology, Genetics and Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. dingyu@scmc.com.cn. FAU - Wang, Xiu-Min AU - Wang XM AUID- ORCID: 0000-0002-2186-759X AD - Department of Endocrinology, Genetics and Metabolism, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, 200127, China. wangxiumin1019@126.com. LA - eng GR - QNWS2024011/Shanghai Oriental Talents Program/ GR - YG2023QNA35/The Fundamental Research Funds for the Central Universities/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251213 PL - Switzerland TA - World J Pediatr JT - World journal of pediatrics : WJP JID - 101278599 SB - IM MH - Humans MH - Female MH - *Menarche/physiology MH - Retrospective Studies MH - *Body Height MH - Child MH - *Age Determination by Skeleton/methods MH - *Knee/diagnostic imaging MH - Wrist/diagnostic imaging MH - Adolescent MH - *Hand Bones/diagnostic imaging MH - China MH - Radiomics PMC - PMC12894113 OTO - NOTNLM OT - Bone age OT - Final height OT - Knee OT - Menarche OT - Radiomic scores COIS- Declarations. Conflict of interest: No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. Authors Yao Chen and Guo-Ying Chang are members of the Youth Editorial Board Member for World Journal of Pediatrics. The paper was handled by the other Editor and has undergone rigorous peer review process. Authors Yao Chen and Guo-Ying Chang were excluded from all editorial decisions related to this manuscript. Ethical approval: The study protocol was approved by the Institutional Ethics Committee of Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China (approval number: SCMCIRB-K2025024-1). The ethics committee granted written consent waiver as this retrospective study used de-identified clinical cases obtained during prior diagnostic/therapeutic procedures. EDAT- 2025/12/14 00:39 MHDA- 2026/02/12 00:47 PMCR- 2025/12/13 CRDT- 2025/12/13 23:06 PHST- 2025/06/03 00:00 [received] PHST- 2025/11/17 00:00 [accepted] PHST- 2025/07/21 00:00 [revised] PHST- 2026/02/12 00:47 [medline] PHST- 2025/12/14 00:39 [pubmed] PHST- 2025/12/13 23:06 [entrez] PHST- 2025/12/13 00:00 [pmc-release] AID - 10.1007/s12519-025-01002-5 [pii] AID - 1002 [pii] AID - 10.1007/s12519-025-01002-5 [doi] PST - ppublish SO - World J Pediatr. 2026 Jan;22(1):129-141. doi: 10.1007/s12519-025-01002-5. Epub 2025 Dec 13. PMID- 41389999 OWN - NLM STAT- MEDLINE DCOM- 20260111 LR - 20260111 IS - 1872-8227 (Electronic) IS - 0168-8227 (Linking) VI - 231 DP - 2026 Jan TI - Prevalence of metabolic syndrome among adolescents in Cape Town, South Africa: a cross-sectional analysis comparing five diagnostic criteria to explore suitability. PG - 113053 LID - S0168-8227(25)01068-X [pii] LID - 10.1016/j.diabres.2025.113053 [doi] AB - BACKGROUND: Metabolic syndrome (MetS) among adolescents is a growing public health concern globally, yet data from sub-Saharan Africa remain scarce. Variability in diagnostic criteria further complicates surveillance efforts. This study aimed to estimate the prevalence of MetS among adolescents in Cape Town, South Africa, using five diagnostic criteria, to assess the agreement between definitions and explore criteria suitability. METHODS: We conducted a cross-sectional study among 489 adolescents aged 13-18 years, sampled from coeducational public high schools in Cape Town's Metro South district. Anthropometric, blood pressure, and fasting biochemical measurements were collected. MetS prevalence was assessed using the Cook, Ford, de Ferranti, International Diabetes Federation (IDF), and Agudelo criteria. Agreement between definitions was evaluated using unweighted Kappa statistics. RESULTS: The MetS prevalence with four criteria were similar, ranging from 4.7 % (IDF) to 5.7 % (Ford), while one criterion differed significantly with 17.8 % (de Ferranti). Central obesity and raised blood pressure were the most prevalent MetS components across criteria. Females exhibited higher MetS prevalence than males across the five criteria. Very good agreement was observed between Cook, Ford, and Agudelo definitions (kappa > 0.85), while agreement involving IDF and de Ferranti definitions was fair to moderate (kappa = 0.33-0.42). CONCLUSIONS: Our results underscore the need for locally validated, population-specific MetS criteria and diagnostic thresholds to support early identification of adolescents at risk of cardiometabolic disease (CMD). In the absence of such criteria, the Cook and Ford definitions appear particularly suitable for identifying MetS among South African adolescents, while the Agudelo definition is appropriate when waist circumference (WC) measures are unavailable. Finally, our findings reveal a concerning CMD risk profile among adolescents in Cape Town, South Africa, with a particularly high burden observed in females. CI - Copyright (c) 2025 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Wentzel, Annalie AU - Wentzel A AD - School of Public Health, University of the Western Cape, Bellville 7535, South Africa; Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg 7505, South Africa. Electronic address: 3814491@myuwc.ac.za. FAU - Nguyen, Kim Anh AU - Nguyen KA AD - Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg 7505, South Africa. FAU - von Philipsborn, Peter AU - von Philipsborn P AD - Chair of Public Health Nutrition, University of Bayreuth, Bayreuth, Germany; Pettenkofer School of Public Health, Ludwig-Maximilians-Universitat Munchen, Munich, Germany. FAU - Levitt, Naomi AU - Levitt N AD - Chronic Disease Initiative for Africa, Department of Medicine, University of Cape Town, Rondebosch 7700, South Africa. FAU - Mchiza, Zandile J R AU - Mchiza ZJR AD - School of Public Health, University of the Western Cape, Bellville 7535, South Africa; Non-Communicable Diseases Research Unit, South African Medical Research Council, Tygerberg 7505, South Africa. LA - eng PT - Comparative Study PT - Journal Article DEP - 20251211 PL - Ireland TA - Diabetes Res Clin Pract JT - Diabetes research and clinical practice JID - 8508335 SB - IM MH - Humans MH - *Metabolic Syndrome/epidemiology/diagnosis MH - Adolescent MH - South Africa/epidemiology MH - Female MH - Cross-Sectional Studies MH - Male MH - Prevalence OTO - NOTNLM OT - Adolescents OT - Cardiometabolic Risk OT - Diagnostic Criteria OT - Metabolic Syndrome OT - South Africa COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/14 00:39 MHDA- 2026/01/12 00:37 CRDT- 2025/12/13 19:35 PHST- 2025/08/05 00:00 [received] PHST- 2025/12/01 00:00 [revised] PHST- 2025/12/10 00:00 [accepted] PHST- 2026/01/12 00:37 [medline] PHST- 2025/12/14 00:39 [pubmed] PHST- 2025/12/13 19:35 [entrez] AID - S0168-8227(25)01068-X [pii] AID - 10.1016/j.diabres.2025.113053 [doi] PST - ppublish SO - Diabetes Res Clin Pract. 2026 Jan;231:113053. doi: 10.1016/j.diabres.2025.113053. Epub 2025 Dec 11. PMID- 41389132 OWN - NLM STAT- MEDLINE DCOM- 20260922 LR - 20261008 IS - 1432-1971 (Electronic) IS - 0172-0643 (Linking) VI - 47 IP - 7 DP - 2026 Oct TI - Enhancing Cardiopulmonary Exercise Testing in Complex Congenital Heart Disease: The Role of Spirometry, Body Composition, and Handgrip Strength. PG - 2796-2807 LID - 10.1007/s00246-025-04134-7 [doi] AB - Cardiopulmonary exercise testing (CPET) is a cornerstone of functional assessment in congenital heart disease (CHD), yet there are additional important contributors to exercise limitation that are not directly measured by CPET. This narrative review highlights the complementary utility of spirometry, body composition analysis, and evaluation of handgrip strength in augmenting our understanding of functional capacity in CHD. Spirometry provides insights into restrictive lung disease patterns prevalent in post-surgical CHD populations; body composition analysis, especially lean mass assessment, can reveal sarcopenia not apparent using BMI alone; and handgrip strength serves as a validated surrogate for overall muscular function and frailty. We propose routine integration of all three testing techniques as complements to CPET protocols to enhance clinical assessment, guide rehabilitation, and support prognostication in pediatric CHD patients. This review advocates for broader adoption and standardization of these measures in clinical settings to improve risk stratification and long-term outcomes. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Wang, Alan P AU - Wang AP AD - Division of Pediatric Cardiology, Mayo Clinic, 200 1 st Street SW, Rochester, MN, 55905, USA. Wang.alan@mayo.edu. FAU - Garcia, Clara AU - Garcia C AD - Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago Avenue, Chicago, IL, 60611, USA. FAU - Schellenberg, Dylan AU - Schellenberg D AD - Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago Avenue, Chicago, IL, 60611, USA. FAU - Griffith, Garett J AU - Griffith GJ AD - Northwestern University Department of Physical Therapy and Human Movement Sciences, 645 N. Michigan Ave., Suite 1100, Chicago, 60611, USA. FAU - Ward, Kendra AU - Ward K AD - Division of Pediatric Cardiology, Ann & Robert H. Lurie Children's Hospital of Chicago, 225 E. Chicago Avenue, Chicago, IL, 60611, USA. LA - eng PT - Journal Article PT - Review DEP - 20251213 PL - United States TA - Pediatr Cardiol JT - Pediatric cardiology JID - 8003849 SB - IM MH - Humans MH - *Hand Strength MH - *Spirometry MH - *Heart Defects, Congenital/physiopathology/diagnosis MH - *Body Composition MH - *Exercise Test/methods MH - Exercise Tolerance MH - Child OTO - NOTNLM OT - Bioelectrical impedance analysis OT - Body composition analysis OT - Cardiopulmonary exercise testing OT - Dual-energy x-ray absorptiometry OT - Exercise capacity OT - Handgrip strength OT - Pediatric OT - Spirometry COIS- Declarations. Conflict of interest: The authors declare no competing interests. EDAT- 2025/12/13 13:00 MHDA- 2026/09/22 21:36 CRDT- 2025/12/13 11:12 PHST- 2025/09/26 00:00 [received] PHST- 2025/11/29 00:00 [accepted] PHST- 2026/09/22 21:36 [medline] PHST- 2025/12/13 13:00 [pubmed] PHST- 2025/12/13 11:12 [entrez] AID - 10.1007/s00246-025-04134-7 [pii] AID - 10.1007/s00246-025-04134-7 [doi] PST - ppublish SO - Pediatr Cardiol. 2026 Oct;47(7):2796-2807. doi: 10.1007/s00246-025-04134-7. Epub 2025 Dec 13. PMID- 41388928 OWN - NLM STAT- MEDLINE DCOM- 20251213 LR - 20260925 IS - 2045-7634 (Electronic) IS - 2045-7634 (Linking) VI - 14 IP - 24 DP - 2025 Dec TI - Prognostic Value of Massiveness Parameters Measured on Baseline FDG PET in Advanced-Stage Hodgkin Lymphoma. PG - e71462 LID - 10.1002/cam4.71462 [doi] LID - e71462 AB - PURPOSE: The prognostic value of radiomic quantitative features measured on pretreatment (18)F-FDG PET/CT was investigated in patients with advanced-stage Hodgkin lymphoma (HL). METHODS: We conducted a retrospective study of 176 HL patients diagnosed between 2006 and 2017. A dozen of PET/CT-derived features were extracted via Oncometer3D from baseline (18)F-FDG PET/CT images. The receiver operating characteristic (ROC) curves, Kaplan-Meier method, and Cox analyses were used to assess the prognostic factors for Overall Survival (OS) and Progression-Free Survival (PFS) censored at 5 years. RESULTS: Four different clusters were identified among the 12 PET parameters analyzed: activity, tumor burden, fragmentation-massiveness, and dispersion. On ROC analyses, medEdgeD, a massiveness parameter, had the highest AUC for OS (0.72) and PFS (0.6). Patients with high baseline medEdgeD had a significantly worse PFS (p = 0.04) and OS (p = 0.003) in both Kaplan-Meier and Cox univariate analyses. Furthermore, medEdgeD remained statistically significant in a multivariate analysis (p = 0.008 for OS and p = 0.014 for PFS) including various TEP and clinical parameters used in daily routine. In addition, in sub-group analyses, a significantly worse prognosis was observed for patients with ABVD and with high baseline medEdgeD value (p = 0.0082 for OS and p = 0.001 for PFS). Moreover, in the bulky subgroup, medEdgeD improved prognostic accuracy (p = 0.016). CONCLUSION: PET parameters describing massiveness, in particular medEdgeD, are significantly correlated with prognosis in HL patients for OS and PFS, especially when treated with ABVD. CI - (c) 2025 The Author(s). Cancer Medicine published by John Wiley & Sons Ltd. FAU - Draye-Carbonnier, S AU - Draye-Carbonnier S AUID- ORCID: 0009-0005-3548-9461 AD - Department of Nuclear Medicine, Centre Henri Becquerel, Rouen, France. FAU - Mihailescu, S-D AU - Mihailescu SD AD - Department of Statistics and Clinical Research Unit, Centre Henri Becquerel, Rouen, France. FAU - Pinochet, P AU - Pinochet P AD - Department of Nuclear Medicine, Centre Henri Becquerel, Rouen, France. FAU - Texte, E AU - Texte E AD - Department of Nuclear Medicine, Centre Henri Becquerel, Rouen, France. FAU - Stamatoullas-Bastard, A AU - Stamatoullas-Bastard A AD - Department of Hematology, Centre Henri Becquerel, Rouen, France. FAU - Vera, P AU - Vera P AD - Department of Nuclear Medicine, Centre Henri Becquerel, Rouen, France. AD - QuantIF-LITIS (EA 4108-FR CNRS 3638), Faculty of Medicine, University of Rouen, Rouen, France. FAU - Becker, S AU - Becker S AD - Department of Nuclear Medicine, Centre Henri Becquerel, Rouen, France. AD - QuantIF-LITIS (EA 4108-FR CNRS 3638), Faculty of Medicine, University of Rouen, Rouen, France. FAU - Decazes, P AU - Decazes P AD - Department of Nuclear Medicine, Centre Henri Becquerel, Rouen, France. AD - QuantIF-LITIS (EA 4108-FR CNRS 3638), Faculty of Medicine, University of Rouen, Rouen, France. LA - eng PT - Journal Article PL - United States TA - Cancer Med JT - Cancer medicine JID - 101595310 RN - 0Z5B2CJX4D (Fluorodeoxyglucose F18) RN - 0 (Radiopharmaceuticals) SB - IM MH - Humans MH - *Hodgkin Disease/diagnostic imaging/mortality/pathology/drug therapy MH - Male MH - Female MH - *Fluorodeoxyglucose F18/administration & dosage MH - Adult MH - Middle Aged MH - Retrospective Studies MH - *Positron Emission Tomography Computed Tomography/methods MH - Prognosis MH - Young Adult MH - Neoplasm Staging MH - Adolescent MH - Aged MH - Radiopharmaceuticals MH - ROC Curve MH - Tumor Burden MH - Kaplan-Meier Estimate MH - Antineoplastic Combined Chemotherapy Protocols/therapeutic use PMC - PMC12701620 OTO - NOTNLM OT - 18F-FDG PET/CT OT - Hodgkin lymphoma OT - outcome prediction OT - prognosis OT - radiomics COIS- The authors declare no conflicts of interest. EDAT- 2025/12/13 12:59 MHDA- 2025/12/13 13:00 PMCR- 2025/12/13 CRDT- 2025/12/13 08:22 PHST- 2025/10/05 00:00 [revised] PHST- 2025/06/25 00:00 [received] PHST- 2025/11/29 00:00 [accepted] PHST- 2025/12/13 13:00 [medline] PHST- 2025/12/13 12:59 [pubmed] PHST- 2025/12/13 08:22 [entrez] PHST- 2025/12/13 00:00 [pmc-release] AID - CAM471462 [pii] AID - 10.1002/cam4.71462 [doi] PST - ppublish SO - Cancer Med. 2025 Dec;14(24):e71462. doi: 10.1002/cam4.71462. PMID- 41388322 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260211 LR - 20260212 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2025 Dec 13 TI - Food addiction in children: a network analysis of nutritional, metabolic, and sociodemographic factors. PG - 47 LID - 10.1186/s40337-025-01495-5 [doi] LID - 47 AB - BACKGROUND: Food addiction (FA) is a condition in which ultra-processed foods (UPFs) activate the brain's reward pathways, leading to binge eating, loss of control, and continued consumption despite negative consequences. It can appear early in childhood and is linked to behavioral, sociodemographic, and metabolic factors. This study assessed the contribution of FA, its structure, and connectivity in relation to sociodemographic, nutritional status, and metabolic variables in network analysis. METHODS: A cross-sectional study was conducted with 93 children (7-11 years old) living in Vitoria de Santo Antao, Brazil. FA was assessed using the Yale Food Addiction Scale for Children, which was translated and validated for the Brazilian child population. Sociodemographic (age, sex, race, socioeconomic class), anthropometric (body weight, height, waist circumference, BMI, BMI-for-age, body fat percentage, lean mass, and fat mass), and metabolic (blood pressure, total cholesterol, triglycerides, HDL, LDL, and fasting glucose) factors were analyzed. For network analysis, the degree centrality (DC), closeness centrality (CC), betweenness centrality (BC), and eigenvector centrality (EC) were evaluated. RESULTS: FA exhibited moderate centrality in sociodemographic and metabolic networks, acting as a connector between key variables such as age and socioeconomic class (BC = 0.071-0.500; EC = 0.301-0.500; CC = 0.636-0.667). These metrics indicate that FA, while not dominant, maintains access to influential nodes and participates in relevant information pathways. In contrast, within the anthropometric network, FA showed a peripheral role, with fewer direct links (DC = 0.222-0.285) and limited intermediation (BC = 0.111). CONCLUSION: Variation in centrality across domains underscores the selective integration of FA, suggesting that its impact is context dependent. CI - (c) 2026. The Author(s). FAU - Carvalho Jurema Santos, Gabriela AU - Carvalho Jurema Santos G AD - Federal University of Pernambuco, Academic Center of Vitoria, Vitoria de Santo Antao, Brazil. gabriela.cjsantos@ufpe.br. FAU - Goes Pacheco, Andre Luiz AU - Goes Pacheco AL AD - Federal University of Pernambuco, Academic Center of Vitoria, Vitoria de Santo Antao, Brazil. FAU - Almeida Oliveira, Tafnes AU - Almeida Oliveira T AD - Federal University of Pernambuco, Academic Center of Vitoria, Vitoria de Santo Antao, Brazil. FAU - Ribeiro Nogueira, Isabella AU - Ribeiro Nogueira I AD - Federal University of Pernambuco, Academic Center of Vitoria, Vitoria de Santo Antao, Brazil. FAU - Costa, Jonathan Manoel AU - Costa JM AD - Federal University of Pernambuco, Academic Center of Vitoria, Vitoria de Santo Antao, Brazil. FAU - Nobre, Isabele Goes AU - Nobre IG AD - Federal University of Pernambuco, Academic Center of Vitoria, Vitoria de Santo Antao, Brazil. FAU - Canuto, Raquel AU - Canuto R AD - Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, Brazil. FAU - Leandro, Carol Gois AU - Leandro CG AD - Federal University of Pernambuco, Academic Center of Vitoria, Vitoria de Santo Antao, Brazil. carol.leandro@ufpe.br. LA - eng GR - 316405/2025-6/National Council for Scientific and Technological Development/ GR - 0233-4.05/25/Fundacao de Amparo a Ciencia e Tecnologia do Estado de Pernambuco/ GR - 1440-4.05/24/Fundacao de Amparo a Ciencia e Tecnologia do Estado de Pernambuco/ GR - 312079/2021-4/Conselho Nacional de Desenvolvimento Cientifico e Tecnologico/ GR - 797-20/Coordination for the Improvement of Higher Level or Education Personnel/ PT - Journal Article DEP - 20251213 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC12888354 OAB - Food addiction involves the uncontrolled and impulsive consumption of ultra-processed foods and can occur in childhood. Several factors may be associated with this condition; therefore, this study evaluates the contribution of food addiction within a network analysis framework including sociodemographic, nutritional, and metabolic variables. This study was conducted in Vitoria de Santo Antao, Brazil, with children aged 7 to 11 years. Three networks were constructed to analyze the association between food addiction and sociodemographic, anthropometric, and metabolic factors. Food addiction played a moderate role in the sociodemographic and metabolic networks, acting as a link between factors such as age and socioeconomic status. In contrast, in the anthropometric network, it had little influence, appearing more isolated and showing few direct connections with other variables. OABL- eng OTO - NOTNLM OT - Addictive behavior OT - Children OT - Complex network OT - Food consumption OT - High-order complex network OT - Nutritional status COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Research Ethics Committee of the Federal University of Pernambuco (number: 38865920.6.0000.5208). An informed consent form was given to parents and children before the assessments, and the principles of the Declaration of Helsinki were followed. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/13 06:29 MHDA- 2025/12/13 06:30 PMCR- 2025/12/13 CRDT- 2025/12/13 00:40 PHST- 2025/08/23 00:00 [received] PHST- 2025/12/01 00:00 [accepted] PHST- 2025/12/13 06:30 [medline] PHST- 2025/12/13 06:29 [pubmed] PHST- 2025/12/13 00:40 [entrez] PHST- 2025/12/13 00:00 [pmc-release] AID - 10.1186/s40337-025-01495-5 [pii] AID - 1495 [pii] AID - 10.1186/s40337-025-01495-5 [doi] PST - epublish SO - J Eat Disord. 2025 Dec 13;14(1):47. doi: 10.1186/s40337-025-01495-5. PMID- 41387933 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260121 LR - 20260123 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 14 IP - 1 DP - 2025 Dec 12 TI - Exploring markers of feasibility for a pragmatic study of biomarkers in adolescents with eating disorders: steps towards a precision psychiatry approach. PG - 17 LID - 10.1186/s40337-025-01490-w [doi] LID - 17 AB - OBJECTIVE: To examine markers of feasibility for a pragmatic interdisciplinary multi-axial study of biomarkers in adolescents with eating disorders (EDs). METHOD: The study included the collection of medical and clinical variables, psychometric measures, dietary logs, sensory and sleep assessments, and biological samples (i.e., blood and stool collection) for biomarker analyses. Adolescents between the ages of 11 to 17 diagnosed with a restrictive ED, along with control participants were enrolled between November 2021 to July 2024. Participants with EDs underwent concurrent treatment while enrolled in the study. Time points for low-weight patients included baseline, 4, 12, and 26 weeks, depending on the biological marker. Control subjects and patients over 90% treatment goal weight were assessed once. Feasibility was evaluated using clinical participant recruitment efficiency and uptake, adherence to the study protocol, rates of study completion, and self-reported ratings of acceptability. RESULTS: In total, 100 participants with an ED, and 52 controls participated. We observed high rates of clinical participant enrolment, high adherence with most protocol collection procedures, modest dropout for longitudinal clinical participants (17% at 12 weeks), and positive feedback returned on surveys. We observed higher dropout at the 26-week timepoint (33%). Food log and sleep assessments were hindered by several contributing factors, resulting in completion rates of 31-70% and 40-87%. DISCUSSION: Overall, results suggest acceptable feasibility for most variables assessed. Protocols requiring participation beyond 12 weeks, and utilizing dietary logs and sleep assessments, should be powered accordingly to account for lower completion rates. Further studies are needed to determine methods to optimize dietary and sleep assessments. This study provides valuable insights that can inform future precision psychiatry ED research strategies. CI - (c) 2025. The Author(s). FAU - Norris, Mark L AU - Norris ML AD - Division of Adolescent Medicine, Department of Pediatrics, Children's Hospital of Eastern Ontario, 401 Smyth Ave, Ottawa, ON, Canada. mnorris@cheo.on.ca. AD - Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Canada. mnorris@cheo.on.ca. AD - Children's Hospital of Eastern Ontario Research Institute (CHEO RI), Ottawa, Canada. mnorris@cheo.on.ca. FAU - Power, Krista A AU - Power KA AD - Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada. AD - School of Nutrition Sciences, Faculty of Health Sciences, University of Ottawa, Ottawa, Canada. FAU - Spettigue, Wendy AU - Spettigue W AD - Children's Hospital of Eastern Ontario Research Institute (CHEO RI), Ottawa, Canada. AD - Department of Psychiatry, Faculty of Medicine, University of Ottawa, Ottawa, Canada. FAU - Lavallee, Niana AU - Lavallee N AD - Children's Hospital of Eastern Ontario Research Institute (CHEO RI), Ottawa, Canada. FAU - Gertler, Madeline J AU - Gertler MJ AD - Children's Hospital of Eastern Ontario Research Institute (CHEO RI), Ottawa, Canada. FAU - Livingston, Dawson B H AU - Livingston DBH AD - Children's Hospital of Eastern Ontario Research Institute (CHEO RI), Ottawa, Canada. AD - Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada. FAU - Rodrigue, Alexane F AU - Rodrigue AF AD - Children's Hospital of Eastern Ontario Research Institute (CHEO RI), Ottawa, Canada. AD - Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Canada. FAU - Porter, Janessa E AU - Porter JE AD - Children's Hospital of Eastern Ontario Research Institute (CHEO RI), Ottawa, Canada. FAU - Pope, Lori AU - Pope L AD - Children's Hospital of Eastern Ontario Research Institute (CHEO RI), Ottawa, Canada. FAU - Harrison, Megan AU - Harrison M AD - Division of Adolescent Medicine, Department of Pediatrics, Children's Hospital of Eastern Ontario, 401 Smyth Ave, Ottawa, ON, Canada. AD - Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Canada. AD - Children's Hospital of Eastern Ontario Research Institute (CHEO RI), Ottawa, Canada. FAU - Kanbur, Nuray AU - Kanbur N AD - Division of Adolescent Medicine, Department of Pediatrics, Children's Hospital of Eastern Ontario, 401 Smyth Ave, Ottawa, ON, Canada. AD - Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Canada. FAU - Goldfield, Gary S AU - Goldfield GS AD - Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Canada. AD - Children's Hospital of Eastern Ontario Research Institute (CHEO RI), Ottawa, Canada. FAU - Isserlin, Leanna AU - Isserlin L AD - Department of Psychiatry, Faculty of Medicine, University of Ottawa, Ottawa, Canada. FAU - Robinson, Amy AU - Robinson A AD - Division of Adolescent Medicine, Department of Pediatrics, Children's Hospital of Eastern Ontario, 401 Smyth Ave, Ottawa, ON, Canada. AD - Department of Pediatrics, Faculty of Medicine, University of Ottawa, Ottawa, Canada. FAU - Obeid, Nicole AU - Obeid N AD - Children's Hospital of Eastern Ontario Research Institute (CHEO RI), Ottawa, Canada. AD - Department of Psychiatry, Faculty of Medicine, University of Ottawa, Ottawa, Canada. LA - eng PT - Journal Article DEP - 20251212 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC12821823 OAB - In this study, we report on the feasibility of collecting biomarker samples in adolescents with eating disorders (ED) to help inform a platform of precision psychiatry research. We included standardized questionnaires, dietary logs, sleep, sensory, and pharmacogenetic assessments, and collected blood and stool samples. Depending on the biomarker and grouping of participants, we collected data at 1, 3 or 4 timepoints. We evaluated feasibility using rates of recruitment, adherence to the protocol, timepoints and study completion, and overall acceptability. We recruited 100 participants with an ED and 52 controls. We observed high rates of clinical enrolment and adherence to most collection procedures, low rates of drop out over the first 12 weeks, and positive feedback returned on surveys. Dietary log completion and sleep assessments were the most challenging research tasks, with the highest rates of non-completion. Our results suggest that most participants followed longitudinally completed testing up to twelve weeks. Protocols requiring participation beyond this timeframe should account for substantial dropout. Further studies are required to investigate the optimal method to track nutritional intake and assess sleep characteristics for research purposes in adolescents with EDs. OABL- eng OTO - NOTNLM OT - Adolescents OT - Anorexia nervosa OT - Eating disorders OT - Feasibility OT - Precision psychiatry COIS- Declarations. Ethics approval and consent to participate: The study was approved but the Research Ethics Board at the Children's Hospital of Eastern Ontario (CHEOREB# 22/43X, 22/20X) and the University of Ottawa Research Ethics Board (REB # H-04-22-7917). Consent for publication: Consent to publish the de-identified study data was obtained by participants who consented to participate in the study. Competing interests: The authors declare no competing interests. EDAT- 2025/12/13 00:32 MHDA- 2025/12/13 00:33 PMCR- 2025/12/12 CRDT- 2025/12/12 23:40 PHST- 2025/05/16 00:00 [received] PHST- 2025/11/28 00:00 [accepted] PHST- 2025/12/13 00:33 [medline] PHST- 2025/12/13 00:32 [pubmed] PHST- 2025/12/12 23:40 [entrez] PHST- 2025/12/12 00:00 [pmc-release] AID - 10.1186/s40337-025-01490-w [pii] AID - 1490 [pii] AID - 10.1186/s40337-025-01490-w [doi] PST - epublish SO - J Eat Disord. 2025 Dec 12;14(1):17. doi: 10.1186/s40337-025-01490-w. PMID- 41387802 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2025 Dec 13 TI - A systematic review of methodological approaches and measurement of adherence to micronutrient supplementation among women of reproductive age in low- and middle-income countries. PG - 313 LID - 10.1186/s12889-025-24944-x [doi] LID - 313 AB - BACKGROUND: Ensuring adherence to recommended micronutrient supplementation regimens is essential for addressing malnutrition among women in low- and middle-income countries (LMICs). While efficacy trials often use biomarker changes as proxies for adherence, public health programs employ diverse methodologies to measure adherence. However, consolidated evidence on the methodological approaches used in these programs and the extent of their standardization remains scarce. This systematic review addresses this gap by exploring adherence measurement methodologies, including adherence thresholds, data collection methods, the number of methods utilized, and measurement frequencies. METHODS: We conducted a literature search on PubMed, Scopus, and Embase. Studies that measured adherence to WHO-recommended micronutrient supplements among women aged 15-49 in LMICs were included. Two reviewers screened titles/abstracts and full texts independently. Fifty-nine articles met the criteria. Data extraction involved four researchers. Article quality was assessed using Cochrane tools. RESULTS: We categorized the included studies into behavioral vs. non-behavioral interventions to identify unique patterns between the two. Across non-behavioral studies, adherence was frequently defined with a threshold of 80%. These studies commonly used pill count to measure adherence and conducted frequent monitoring. Behavioral studies often adopted more diverse thresholds (e.g., 70%, 90 tablets), while 67% of them did not provide a clear threshold to define adherence. Self-report was the most commonly used measurement approach. The use of data triangulation and regular monitoring bolstered the validity of self-reports. CONCLUSIONS: Micronutrient supplementation programs would benefit from adopting evidence-based thresholds to define adherence levels, enhancing comparability across studies. Using a combination of methods and cross-checking data from multiple sources can improve the validity of adherence measurements. We recommend against treating adherence as a static, standalone construct; instead, reporting its trajectory throughout an intervention and its association with health outcomes can provide valuable insights for program planning. In terms of study characteristics, most studies have primarily focused on pregnant and lactating women, leaving adherence measurement approaches among nonpregnant women and adolescents largely understudied. We strongly encourage future research to investigate how methodological issues of adherence is uniquely experienced among this underserved population. FAU - Kang, Bee-Ah AU - Kang BA AD - Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21215, USA. beeah.kang@jhu.edu. FAU - Britton, Jordyn AU - Britton J AD - Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St, Baltimore, MD, 21215, USA. AD - Howard University College of Medicine, 2400 6th St NW, Washington, DC, 20059, USA. FAU - Olarewaju, Olajumoke Kiito AU - Olarewaju OK AD - Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21215, USA. FAU - Luitel, Aditi AU - Luitel A AD - Department of International Health, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St, Baltimore, MD, 21215, USA. AD - Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY, 10461, USA. FAU - Stephens, Daryl AU - Stephens D AD - Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21215, USA. FAU - Rimal, Rajiv N AU - Rimal RN AD - Department of Health, Behavior and Society, Johns Hopkins Bloomberg School of Public Health, 615 N. Wolfe St., Baltimore, MD, 21215, USA. LA - eng GR - INV-035431/GATES/Gates Foundation/United States PT - Journal Article PT - Systematic Review DEP - 20251213 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Female MH - *Dietary Supplements/statistics & numerical data MH - *Micronutrients/administration & dosage MH - *Developing Countries MH - Adolescent MH - Adult MH - *Patient Compliance/statistics & numerical data MH - Middle Aged MH - Young Adult PMC - PMC12836925 OTO - NOTNLM OT - Adherence OT - Compliance OT - Maternal nutrition OT - Micronutrient OT - Micronutrient supplementation OT - Nutritional behavior OT - Women of reproductive age COIS- Declarations. Ethics approval and consent to participate: Not applicable. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/13 00:32 MHDA- 2026/06/27 06:45 PMCR- 2025/12/13 CRDT- 2025/12/12 23:35 PHST- 2024/12/31 00:00 [received] PHST- 2025/09/16 00:00 [accepted] PHST- 2026/06/27 06:45 [medline] PHST- 2025/12/13 00:32 [pubmed] PHST- 2025/12/12 23:35 [entrez] PHST- 2025/12/13 00:00 [pmc-release] AID - 10.1186/s12889-025-24944-x [pii] AID - 24944 [pii] AID - 10.1186/s12889-025-24944-x [doi] PST - epublish SO - BMC Public Health. 2025 Dec 13;26(1):313. doi: 10.1186/s12889-025-24944-x. PMID- 41387712 OWN - NLM STAT- MEDLINE DCOM- 20260203 LR - 20260205 IS - 1941-2444 (Electronic) IS - 0148-6071 (Print) IS - 0148-6071 (Linking) VI - 50 IP - 2 DP - 2026 Feb TI - Epicutaneo-caval catheter occlusion in neonates without heparin infusion during parenteral nutrition: A descriptive cohort study. PG - 247-251 LID - 10.1002/jpen.70037 [doi] AB - BACKGROUND: Heparin is frequently infused in neonatal central venous catheters to prevent occlusion during parenteral nutrition despite limited evidence of its effectiveness and potential safety concerns in preterm infants. This study evaluated the incidence of catheter occlusion in epicutaneo-caval catheters managed without heparin in a large neonatal cohort. METHODS: We conducted a descriptive cohort study including all neonates admitted to the neonatal intensive care unit who required epicutaneo-caval catheters placement for parenteral nutrition. No heparin was added to infusions. Data were collected on catheter characteristics, insertion parameters, and reasons for removal. The primary outcome was the incidence of catheter occlusion per 1000 catheter-days. RESULTS: A total of 357 neonates with 357 epicutaneo-caval catheters were analyzed, representing 4007 catheter-days. Mean +/- SD gestational age was 29 +/- 4.1 weeks, and mean +/- SD birthweight was 1050 +/- 797 g. The mean +/- SD catheter dwell time was 11.2 +/- 7.7 days. Most catheter insertions occurred in the upper extremities (92.7%), with prematurity being the most common indication (53.7%). Catheter removal was elective in 67.5% of cases. Only three occlusions were reported, corresponding to 0.7% of catheters and 0.76 occlusions per 1000 catheter-days. CONCLUSION: This study demonstrates a low rate of epicutaneo-caval catheters occlusion in neonates receiving parenteral nutrition without heparin infusion. These findings support the safety and feasibility of a heparin-free approach in neonatal central catheter management when standardized care protocols are followed. CI - (c) 2025 The Author(s). Journal of Parenteral and Enteral Nutrition published by Wiley Periodicals LLC on behalf of American Society for Parenteral and Enteral Nutrition. FAU - D'Andrea, Vito AU - D'Andrea V AUID- ORCID: 0000-0002-0980-799X AD - Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy. FAU - Prontera, Giorgia AU - Prontera G AD - Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy. FAU - Monachini, Cecilia AU - Monachini C AD - Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy. FAU - Cerreti, Micaela AU - Cerreti M AD - Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy. FAU - Baldo, Francesca AU - Baldo F AD - Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy. FAU - Barone, Giovanni AU - Barone G AD - Neonatal Intensive Care Unit, Infermi Hospital, AUSL Romagna, Rimini, Italy. FAU - Vento, Giovanni AU - Vento G AD - Neonatology Unit, Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario "Agostino Gemelli" IRCCS, Rome, Italy. AD - Neonatology Unit, Universita Cattolica del Sacro Cuore, Rome, Italy. LA - eng PT - Journal Article DEP - 20251212 PL - United States TA - JPEN J Parenter Enteral Nutr JT - JPEN. Journal of parenteral and enteral nutrition JID - 7804134 RN - 9005-49-6 (Heparin) SB - IM MH - Humans MH - Infant, Newborn MH - *Heparin/administration & dosage MH - *Parenteral Nutrition/methods/instrumentation MH - Male MH - Female MH - Cohort Studies MH - Intensive Care Units, Neonatal MH - Infant, Premature MH - *Catheter Obstruction MH - *Central Venous Catheters/adverse effects MH - *Catheterization, Central Venous/adverse effects MH - Gestational Age MH - Incidence PMC - PMC12865733 OTO - NOTNLM OT - NICU OT - catheter occlusion OT - central line maintenance OT - epicutaneo-caval catheter OT - heparin OT - neonates OT - parenteral nutrition COIS- None declared. EDAT- 2025/12/13 00:32 MHDA- 2026/02/03 07:41 PMCR- 2026/02/03 CRDT- 2025/12/12 23:29 PHST- 2025/11/03 00:00 [revised] PHST- 2025/08/20 00:00 [received] PHST- 2025/11/19 00:00 [accepted] PHST- 2026/02/03 07:41 [medline] PHST- 2025/12/13 00:32 [pubmed] PHST- 2025/12/12 23:29 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - JPEN70037 [pii] AID - 10.1002/jpen.70037 [doi] PST - ppublish SO - JPEN J Parenter Enteral Nutr. 2026 Feb;50(2):247-251. doi: 10.1002/jpen.70037. Epub 2025 Dec 12. PMID- 41386999 OWN - NLM STAT- MEDLINE DCOM- 20251212 LR - 20260106 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 12 DP - 2025 Dec 12 TI - DIVINE-pilot trial: a phase 2 multicentre, randomised pilot trial of pharmacotherapy and physical activity monitoring conducted in women with recent gestational diabetes and increased risk of type 2 diabetes recruited from tertiary referral hospitals in Australia. PG - e107551 LID - 10.1136/bmjopen-2025-107551 [doi] LID - e107551 AB - INTRODUCTION: Women who develop gestational diabetes mellitus (GDM) have a 60% lifetime risk of developing type 2 diabetes mellitus (T2D), which is already elevated within the first decade following childbirth. Despite the impact of lifestyle interventions to reduce long-term T2D risk in women with previous GDM, successful implementation of lifestyle interventions remains a barrier. Metformin is recommended for adults at increased risk of developing T2D; however, there is limited evidence of tolerability in the early postpartum period. Glucagon-like peptide 1 receptor agonists (GLP-1 RA) are effective at improving glycaemic status and body weight. However, GLP-1 RA have not been evaluated in the postpartum population. Finally, physical activity monitors may support behaviour changes related to physical activity to reduce long-term risk of T2D but are yet to be studied following GDM. METHODS AND ANALYSIS: This will be a multicentre, randomised, open-label interventional pilot study. Using a 2x2 factorial design, we will examine the feasibility and acceptability of a pharmacotherapy intervention and a physical activity intervention in women with previous GDM at increased risk of developing T2D. Participants will be recruited from tertiary referral hospitals in Australia and will be randomised to receive either metformin alone or in combination with a GLP-1 RA and subsequently randomised to either a physical activity intervention involving activity monitor use, or usual care for 6 months, followed by a 6-month follow-up period. Primary feasibility outcomes include the acceptability and safety of the metformin and GLP-1 RA as measured through pill and injection counts, acceptability questionnaire and adverse events. ETHICS AND DISSEMINATION: This trial is registered with the Australian and New Zealand Clinical Trials Registry (Registration Number: ACTRN12624001253594). This trial has received ethics approval from the South Eastern Sydney Local Health District Human Research Ethics Committee (Approval Number: 2024/ETH00042, protocol version v1.1, 28/02/2025). TRIAL REGISTRATION NUMBER: Australian and New Zealand Clinical Trials Registry, Registration Number: ACTRN12624001253594. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY. Published by BMJ Group. FAU - Chen, Angela Xun-Nan AU - Chen AX AUID- ORCID: 0000-0002-5760-939X AD - Cardiovascular Programme, The George Institute for Global Health, Sydney, New South Wales, Australia achen@georgeinstitute.org.au. AD - Department of Diabetes and Endocrinology, Westmead Hospital, Westmead, New South Wales, Australia. FAU - Lee, Vivian Y AU - Lee VY AUID- ORCID: 0000-0002-9118-9835 AD - Cardiovascular Programme, The George Institute for Global Health, Barangaroo, New South Wales, Australia. FAU - Donges, Katherine AU - Donges K AD - Sydney, Sydney, New South Wales, Australia. FAU - Giancas, Chris AU - Giancas C AD - The George Institute for Global Health, Barangaroo, New South Wales, Australia. FAU - Angell, Blake AU - Angell B AUID- ORCID: 0000-0002-7188-7740 AD - The George Institute for Global Health, Barangaroo, New South Wales, Australia. FAU - Parmenter, Belinda AU - Parmenter B AD - UNSW Medicine and Health Lifestyle Clinic, University of New South Wales, Sydney, New South Wales, Australia. AD - Discipline of Sport and Exercise Science, School of Health, University of the Sunshine Coast - Sunshine Coast Campus, Sippy Downs, Queensland, Australia. FAU - Barrett, Helen L AU - Barrett HL AUID- ORCID: 0000-0001-7141-2086 AD - Obstetric Medicine, Royal Hospital for Women, Randwick, New South Wales, Australia. AD - Discipline of Women's Health, School of Clinical Medicine, University of New South Wales Medicine and Health, Sydney, New South Wales, Australia. FAU - Henry, Amanda AU - Henry A AD - Discipline of Women's Health, School of Clinical Medicine, University of New South Wales Medicine and Health, Sydney, New South Wales, Australia. AD - Women's Health Programme, The George Institute for Global Health, Barangaroo, New South Wales, Australia. AD - Department of Obstetrics and Gynaecology, St George Hospital, Kogarah, New South Wales, Australia. FAU - Patel, Anushka AU - Patel A AD - The George Institute for Global Health, Barangaroo, New South Wales, Australia. FAU - Arnott, Clare AU - Arnott C AD - Cardiovascular Programme, The George Institute for Global Health, Barangaroo, New South Wales, Australia. AD - Department of Cardiology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia. AD - Department of Cardiology, St Vincent's Hospital Sydney, Darlinghurst, New South Wales, Australia. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20251212 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - 0 (Glucagon-Like Peptide-1 Receptor Agonists) RN - 0 (Hypoglycemic Agents) RN - 9100L32L2N (Metformin) SB - IM MH - Adult MH - Female MH - Humans MH - Pregnancy MH - Australia MH - *Diabetes Mellitus, Type 2/prevention & control/etiology MH - *Diabetes, Gestational/therapy/drug therapy MH - *Exercise MH - Glucagon-Like Peptide-1 Receptor Agonists MH - *Hypoglycemic Agents/therapeutic use MH - *Metformin/therapeutic use MH - Multicenter Studies as Topic MH - Pilot Projects MH - Randomized Controlled Trials as Topic MH - Tertiary Care Centers MH - Clinical Trials, Phase II as Topic PMC - PMC12706213 OTO - NOTNLM OT - Cardiovascular Disease OT - Diabetes Mellitus, Type 2 OT - Diabetes in pregnancy OT - Obesity OT - Overweight OT - Randomized Controlled Trial COIS- Competing interests: None declared. EDAT- 2025/12/13 00:32 MHDA- 2025/12/13 00:33 PMCR- 2025/12/12 CRDT- 2025/12/12 21:33 PHST- 2025/12/13 00:33 [medline] PHST- 2025/12/13 00:32 [pubmed] PHST- 2025/12/12 21:33 [entrez] PHST- 2025/12/12 00:00 [pmc-release] AID - bmjopen-2025-107551 [pii] AID - 10.1136/bmjopen-2025-107551 [doi] PST - epublish SO - BMJ Open. 2025 Dec 12;15(12):e107551. doi: 10.1136/bmjopen-2025-107551. PMID- 41386682 OWN - NLM STAT- MEDLINE DCOM- 20260312 LR - 20260427 IS - 1651-2227 (Electronic) IS - 0803-5253 (Linking) VI - 115 IP - 4 DP - 2026 Apr TI - Breastfeeding Ambulatory Supplementation With Preterm Formula Versus Fortifiers Achieves Similar Growth at 40 Weeks: A Pilot Study in Preterm Infants. PG - 865-872 LID - 10.1111/apa.70414 [doi] AB - AIM: This study evaluates whether liquid formula supplementation for preterm infants was non-inferior to breast milk fortifiers regarding growth and adherence to exclusive breastfeeding in an outpatient Kangaroo Mother Care Program from Colombia. METHODS: An open-label randomised trial was initiated in 2016 and interrupted in 2018 because of the lack of fortifiers in the country and included 81 preterm infants born between 32 + 0 and 36 + 6 weeks/days of gestational age. Infants were assigned to receive either breast milk fortifiers or liquid formula, with outcomes assessed up to 40 weeks. RESULTS: No significant differences in anthropometric measurements were observed between the groups. More than two-thirds (69%) achieved exclusive breastfeeding, with higher rates in the fortifier group (73.0% vs. 53.0%, p = 0.06). This tendency persisted up to 6 months of corrected age. Breastfeeding was discontinued more frequently in the liquid formula group despite showing better gastrointestinal tolerance, ease of administration, and lower cost and contamination for home use. CONCLUSIONS: Liquid formula supplementation showed growth outcomes comparable to those of breast milk fortifiers at 40 weeks. Further research with larger samples is recommended to validate outcomes. CI - (c) 2025 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd. FAU - Cadavid, A M AU - Cadavid AM AUID- ORCID: 0009-0006-8896-5684 AD - Integral Kangaroo Mother Care Program, Medellin, Colombia. AD - Kangaroo Foundation, Bogota, Colombia. FAU - Lombo, A AU - Lombo A AD - Integral Kangaroo Mother Care Program, Medellin, Colombia. AD - Kangaroo Foundation, Bogota, Colombia. FAU - Montealegre, A AU - Montealegre A AD - Integral Kangaroo Mother Care Program, Medellin, Colombia. AD - Kangaroo Foundation, Bogota, Colombia. AD - San Ignacio Teaching Hospital, Javeriana University, Bogota, Colombia. FAU - Angel, D A AU - Angel DA AD - Integral Kangaroo Mother Care Program, Bogota, Colombia. FAU - Quevedo, A AU - Quevedo A AD - Department of Pediatrics, Universidad de Antioquia, Medellin, Colombia. FAU - Charpak, N AU - Charpak N AUID- ORCID: 0000-0001-6697-5837 AD - Kangaroo Foundation, Bogota, Colombia. LA - eng GR - Universidad de Antioquia/ PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20251212 PL - Norway TA - Acta Paediatr JT - Acta paediatrica (Oslo, Norway : 1992) JID - 9205968 SB - IM MH - Humans MH - Pilot Projects MH - *Infant, Premature/growth & development MH - *Breast Feeding/statistics & numerical data MH - Infant, Newborn MH - *Infant Formula MH - Female MH - Male MH - *Food, Fortified MH - Colombia OTO - NOTNLM OT - Kangaroo Mother Care OT - ambulatory care OT - growth OT - human milk fortification OT - infant OT - preterm EDAT- 2025/12/13 00:32 MHDA- 2026/03/12 07:03 CRDT- 2025/12/12 20:12 PHST- 2025/11/14 00:00 [revised] PHST- 2025/04/20 00:00 [received] PHST- 2025/12/02 00:00 [accepted] PHST- 2026/03/12 07:03 [medline] PHST- 2025/12/13 00:32 [pubmed] PHST- 2025/12/12 20:12 [entrez] AID - 10.1111/apa.70414 [doi] PST - ppublish SO - Acta Paediatr. 2026 Apr;115(4):865-872. doi: 10.1111/apa.70414. Epub 2025 Dec 12. PMID- 41385787 OWN - NLM STAT- MEDLINE DCOM- 20251212 LR - 20251231 IS - 1438-8871 (Electronic) IS - 1439-4456 (Print) IS - 1438-8871 (Linking) VI - 27 DP - 2025 Dec 12 TI - Lumbar Acceleration Gait Estimation: "Step-by-Step" Algorithm Updates and Improvements. PG - e72831 LID - 10.2196/72831 [doi] LID - e72831 AB - BACKGROUND: Digital health technologies, such as accelerometry, offer low participant burden and provide quantitative metrics with ease of deployment, making them increasingly popular for gait monitoring. Remote gait monitoring delivers quantifiable, continuous health measures over extended periods, surpassing the limited insights from single clinic or laboratory visits and offering a more comprehensive health perspective. Numerous gait algorithm implementations, inspired by prior research, aim to standardize these metrics across devices. The SciKit Digital Health (SKDH) package exemplifies this as a device-agnostic framework. OBJECTIVE: This study introduces a series of literature-informed enhancements to the SKDH gait algorithm, improving its performance against reference standards and reducing the need for manual parameter adjustments across diverse populations. METHODS: A block-wise refinement process was undertaken, examining each algorithmic component for potential enhancements and evaluating their cumulative impact on the complete gait algorithm and the metrics generated. RESULTS: Using data from healthy adult and pediatric participants, the novel gait event estimation method reduced the mean absolute error by more than 50% compared with its predecessor. Following the updates, the intraclass correlation values for final gait metric concordance with the in-laboratory reference improved markedly, from 0.50-0.74 to 0.81-0.90. Additionally, the systematic bias observed in the previous version's gait speed estimation was rectified, narrowing the difference from the reference from 0.065-0.230 to 0.00-0.03 m/s. CONCLUSIONS: The findings from this study provide robust evidence supporting the validity of the enhancements made to the gait algorithm. They demonstrate that a single lumbar accelerometer can capture gait characteristics with high accuracy and reliability across various speeds and age groups. CI - (c)Lukas Adamowicz, Wenyi Lin, F Isik Karahanoglu, Xuemei Cai, Mar Santamaria, Charmaine Demanuele, Junrui Di. Originally published in the Journal of Medical Internet Research (https://www.jmir.org), 12.12.2025. FAU - Adamowicz, Lukas AU - Adamowicz L AUID- ORCID: 0000-0001-6992-9545 AD - AI/ML Quantitative Digital Sciences, Pfizer Research and Development, Pfizer, Cambridge, MA, United States. FAU - Lin, Wenyi AU - Lin W AUID- ORCID: 0000-0001-8767-1795 AD - AI/ML Quantitative Digital Sciences, Pfizer Research and Development, Pfizer, Cambridge, MA, United States. FAU - Karahanoglu, F Isik AU - Karahanoglu FI AUID- ORCID: 0000-0002-9162-8367 AD - AI/ML Quantitative Digital Sciences, Pfizer Research and Development, Pfizer, Cambridge, MA, United States. FAU - Cai, Xuemei AU - Cai X AUID- ORCID: 0000-0001-9822-9935 AD - Biomeasures, Endpoints, and Study Technologies, Pfizer Research and Development, Pfizer, Cambridge, MA, United States. FAU - Santamaria, Mar AU - Santamaria M AUID- ORCID: 0009-0009-7770-9425 AD - Biomeasures, Endpoints, and Study Technologies, Pfizer Research and Development, Pfizer, Cambridge, MA, United States. FAU - Demanuele, Charmaine AU - Demanuele C AUID- ORCID: 0000-0002-7715-9920 AD - AI/ML Quantitative Digital Sciences, Pfizer Research and Development, Pfizer, Cambridge, MA, United States. FAU - Di, Junrui AU - Di J AUID- ORCID: 0000-0001-6325-8090 AD - AI/ML Quantitative Digital Sciences, Pfizer Research and Development, Pfizer, Cambridge, MA, United States. LA - eng PT - Journal Article DEP - 20251212 PL - Canada TA - J Med Internet Res JT - Journal of medical Internet research JID - 100959882 SB - IM MH - Humans MH - *Algorithms MH - *Gait/physiology MH - Adult MH - *Accelerometry MH - Child MH - Male MH - Female MH - *Gait Analysis/methods MH - Young Adult MH - *Lumbosacral Region/physiology MH - Acceleration PMC - PMC12743242 OTO - NOTNLM OT - IMU OT - accelerometer OT - gait OT - walking OT - walking speed COIS- Conflicts of Interest: All authors were employees and shareholders of Pfizer, Inc during the conduct and writing of the paper. EDAT- 2025/12/12 19:28 MHDA- 2025/12/12 19:29 PMCR- 2025/12/12 CRDT- 2025/12/12 16:54 PHST- 2025/02/19 00:00 [received] PHST- 2025/11/07 00:00 [accepted] PHST- 2025/12/12 19:29 [medline] PHST- 2025/12/12 19:28 [pubmed] PHST- 2025/12/12 16:54 [entrez] PHST- 2025/12/12 00:00 [pmc-release] AID - v27i1e72831 [pii] AID - 10.2196/72831 [doi] PST - epublish SO - J Med Internet Res. 2025 Dec 12;27:e72831. doi: 10.2196/72831. PMID- 41384644 OWN - NLM STAT- MEDLINE DCOM- 20260307 LR - 20260920 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 82 IP - 3 DP - 2026 Mar TI - Vibration-controlled transient elastography in pediatric metabolic dysfunction-associated steatotic liver disease. PG - 741-750 LID - 10.1002/jpn3.70284 [doi] AB - OBJECTIVES: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent disease in children. Vibration-controlled transient elastography (VCTE) offers a noninvasive alternative to liver biopsy, using controlled attenuation parameter (CAP) to estimate steatosis and liver stiffness measurement (LSM) for fibrosis. However, pediatric data with histological validation are limited. This prospective, multicenter study evaluated the accuracy of CAP and LSM in pediatric MASLD. METHODS: Children with histologically confirmed MASLD from the Nonalcoholic Steatohepatitis Clinical Research Network (NASH CRN) Database 3 underwent VCTE within 6 months of liver biopsy. CAP was evaluated for correlation with steatosis grades, and LSM for correlation with fibrosis stages. The diagnostic performance of LSM in distinguishing fibrosis stages was analyzed using histological findings as the reference standard. RESULTS: Among 92 children with MASLD (mean age 13 +/- 3 years), CAP values were similar across steatosis grades (median 325, 310, and 323 dB/m for grades 1-3, respectively) and showed no significant correlation with histologic steatosis (p = 0.422). Median LSM values increased with fibrosis stage (6.0-8.8 kPa), but significant differences were detected only between stage 0 and stage 3 fibrosis (p = 0.037). For advanced fibrosis (stages 3-4), area under the receiver operating characteristic curve was 0.67, with sensitivity 67%, specificity 76%, positive predictive value 40%, and negative predictive value 90%. CONCLUSION: In this prospective, multicenter cohort, VCTE showed modest accuracy for grading steatosis or staging fibrosis in pediatric MASLD. Improved noninvasive methods are urgently needed for evaluation and monitoring in this population. CI - (c) 2025 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Nichols, Lauren B AU - Nichols LB AUID- ORCID: 0009-0000-6937-0550 AD - Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, California, USA. AD - Department of Gastroenterology, Rady Children's Hospital, San Diego, California, USA. FAU - Oakes, Sebastian G J AU - Oakes SGJ AUID- ORCID: 0009-0004-0613-7881 AD - Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, California, USA. AD - Earl Warren College, University of California San Diego, La Jolla, California, USA. FAU - Behling, Cynthia AU - Behling C AUID- ORCID: 0000-0001-7016-2636 AD - Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, California, USA. FAU - Adams, Kathryn Harlow AU - Adams KH AUID- ORCID: 0000-0003-1478-5235 AD - Department of Pediatrics, Riley Children's Hospital, Indianapolis, Indiana, USA. FAU - Fishbein, Mark H AU - Fishbein MH AUID- ORCID: 0000-0002-3597-3748 AD - Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, USA. FAU - Hertel, Paula AU - Hertel P AUID- ORCID: 0000-0002-2314-7297 AD - Department of Pediatrics, Texas Children's Hospital, Houston, Texas, USA. FAU - Jarasvaraparn, Chao AU - Jarasvaraparn C AUID- ORCID: 0000-0001-8076-9378 AD - Department of Pediatrics, Riley Children's Hospital, Indianapolis, Indiana, USA. FAU - Molleston, Jean P AU - Molleston JP AUID- ORCID: 0000-0002-8708-0298 AD - Department of Pediatrics, Riley Children's Hospital, Indianapolis, Indiana, USA. FAU - Mouzaki, Marialena AU - Mouzaki M AUID- ORCID: 0000-0002-6186-2443 AD - Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. AD - College of Medicine University of Cincinnati, Cincinnati, Ohio, USA. FAU - Sirlin, Claude B AU - Sirlin CB AUID- ORCID: 0000-0002-6639-9072 AD - Radiology, UCSD, La Jolla, California, USA. FAU - Vos, Miriam B AU - Vos MB AUID- ORCID: 0000-0002-0817-7068 AD - Department of Pediatrics, Emory University, Atlanta, Georgia, USA. FAU - Wilson, Laura A AU - Wilson LA AUID- ORCID: 0000-0002-6294-4504 AD - Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA. FAU - Xanthakos, Stavra A AU - Xanthakos SA AUID- ORCID: 0000-0001-9179-005X AD - Department of Pediatrics, Division of Gastroenterology, Hepatology and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA. AD - College of Medicine University of Cincinnati, Cincinnati, Ohio, USA. FAU - Schwimmer, Jeffrey B AU - Schwimmer JB AUID- ORCID: 0000-0001-8538-2877 AD - Department of Pediatrics, Division of Gastroenterology, Hepatology, and Nutrition, University of California San Diego School of Medicine, La Jolla, California, USA. AD - Department of Gastroenterology, Rady Children's Hospital, San Diego, California, USA. CN - NASH CRN LA - eng GR - U01DK061737/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - UL1TR000454/National Center for Advancing Translational Sciences (NCATS)/ GR - U01 DK061718/DK/NIDDK NIH HHS/United States GR - UL1 TR000006/TR/NCATS NIH HHS/United States GR - U01DK061738/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - UL1TR000004/National Center for Advancing Translational Sciences (NCATS)/ GR - UL1 TR000454/TR/NCATS NIH HHS/United States GR - U01 DK061734/DK/NIDDK NIH HHS/United States GR - U24DK061730/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - UL1 TR000077/TR/NCATS NIH HHS/United States GR - UL1 TR000004/TR/NCATS NIH HHS/United States GR - U01 DK061737/DK/NIDDK NIH HHS/United States GR - U01 DK061713/DK/NIDDK NIH HHS/United States GR - U01DK061730/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - U01 DK061732/DK/NIDDK NIH HHS/United States GR - UL1 TR000150/TR/NCATS NIH HHS/United States GR - UL1TR000006/National Center for Advancing Translational Sciences (NCATS)/ GR - U01DK061734/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - Intramural Division of the National Cancer Institute (NCI)/ GR - U01 DK061730/DK/NIDDK NIH HHS/United States GR - U24 DK061730/DK/NIDDK NIH HHS/United States GR - U01 DK061728/DK/NIDDK NIH HHS/United States GR - U01DK061728/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - UL1TR000100/National Center for Advancing Translational Sciences (NCATS)/ GR - U01 DK061738/DK/NIDDK NIH HHS/United States GR - UL1TR000448/National Center for Advancing Translational Sciences (NCATS)/ GR - UL1 TR000448/TR/NCATS NIH HHS/United States GR - U01DK061713/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - U01DK061732/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - U01DK061718/National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)/ GR - UL1 TR000423/TR/NCATS NIH HHS/United States GR - UL1 TR000100/TR/NCATS NIH HHS/United States GR - UL1 TR002345/TR/NCATS NIH HHS/United States GR - UL1TR000423/National Center for Advancing Translational Sciences (NCATS)/ GR - UL1TR000150/National Center for Advancing Translational Sciences (NCATS)/ GR - UL1TR000077/National Center for Advancing Translational Sciences (NCATS)/ PT - Journal Article PT - Multicenter Study DEP - 20251212 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 SB - IM MH - Humans MH - *Elasticity Imaging Techniques/methods MH - Male MH - Female MH - Adolescent MH - Child MH - Prospective Studies MH - Vibration MH - *Liver Cirrhosis/diagnostic imaging/pathology/diagnosis MH - *Non-alcoholic Fatty Liver Disease/diagnostic imaging/pathology MH - *Liver/pathology/diagnostic imaging MH - Severity of Illness Index MH - Sensitivity and Specificity MH - *Fatty Liver/diagnostic imaging/pathology MH - ROC Curve PMC - PMC12964508 MID - NIHMS2154640 OTO - NOTNLM OT - cirrhosis OT - diagnostic accuracy OT - noninvasive test OT - obesity OT - steatohepatitis COIS- Lauren B. Nichols, Sebastian G. J. Oakes, Cynthia Behling, Kathryn Harlow Adams, Mark H. Fishbein, Paula Hertel, Chao Jarasvaraparn, Marialena Mouzaki, Laura A. Wilson: No conflicts of interest to report. Jean Molleston: Research grants to Indiana University from Mirum, Abbvie, Albireo, Gillead. Claude Sirlin: Reports payment to institution for research grants from ACR, Bayer, Foundation of NIH, GE, Gilead, Pfizer, Philips, Siemens, V Foundation; payment to institution for lab service agreements with OrsoBio, Enanta, Gilead, ICON, Intercept, Nusirt, Shire, Synageva, Takeda; payment to institution for institutional consulting for BMS, Exact Sciences, IBM-Watson, Pfizer; Personal consulting for Altimmune, Ascelia Pharma, Blade, Boehringer, Epigenomics, Guerbet, Livivos, and Novo Nordisk; payment to self for royalties and/or honoraria from Medscape, Wolters Kluwer, and HealthProMatch; ownership of stock options in Livivos; unpaid advisory board position in Quantix Bio; executive position for Livivos (Chief Medical Officer, unsalaried position with stock options and stock) through June 28, 2023; Principal Scientific Advisor to Livivos (unsalaried position with stock options and stock) since June 28, 2023; payment to self for serving as a speaker for HealthProMatch; support for attending meetings and/or travel from Fundacion Santa Fe, Congreso Argentino de Diagnostico por Imagenes, Stanford, Jornada Paulista de Radiologia, Ascelia Pharma, RSNA, Sociedad Radiologica de Puerto Rico, Hospital Espanol Auxilio Mutuo de Puerto Rico, Paris MASH, and Liver Forum; member (no payment) of Data Safety Monitoring board for National Cancer Institute funded Early Detection Research Network; equipment loans to institution from Butterfly, GE, Siemens, and Mayo; provision of contrast material to institution from Bayer. Miriam Vos: Research grants to Emory from Target NASH, Quest, Labcorp, and Sonic Incytes Medical Corp. Consultant to Boehringer Ingelheim, Novo Nordisk, Eli Lilly, Intercept, Takeda, and Alberio. Has stock or stock options in Thiogenesis and Tern Pharmaceuticals. Stavra A. Xanthakos: Research grants to Cincinnati Children's from Target NASH. Jeffrey B. Schwimmer: Grant support to UC San Diego from Seraphina, Intercept. Consultant for Merck. EDAT- 2025/12/12 17:54 MHDA- 2026/03/07 18:38 PMCR- 2026/03/06 CRDT- 2025/12/12 08:23 PHST- 2025/10/23 00:00 [revised] PHST- 2025/06/10 00:00 [received] PHST- 2025/11/01 00:00 [accepted] PHST- 2026/03/07 18:38 [medline] PHST- 2025/12/12 17:54 [pubmed] PHST- 2025/12/12 08:23 [entrez] PHST- 2026/03/06 00:00 [pmc-release] AID - JPN370284 [pii] AID - 10.1002/jpn3.70284 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Mar;82(3):741-750. doi: 10.1002/jpn3.70284. Epub 2025 Dec 12. PMID- 41384455 OWN - NLM STAT- MEDLINE DCOM- 20251212 LR - 20260919 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 1 DP - 2026 Mar TI - Diagnosing Breastfeeding Difficulties: Where Do We Stand? PG - e70153 LID - 10.1111/mcn.70153 [doi] LID - e70153 AB - Despite lactation being a natural occurrence in mammals, many structural barriers and individual factors can impact the ability of a woman to breastfeed her newborn. At the individual level, evidence has widely documented several risk factors and societal barriers for impaired lactation, many of which have been steeply increasing in human societies in the past few decades (e.g., psychosocial stress, metabolic disorders, births interventions, etc.). Yet the healthcare system worldwide does not seem to be prepared to support women facing such breastfeeding difficulties. Pregnant women are often provided with unrealistic expectations of how the breastfeeding experience should unfold, which can then translate into negative feelings when they encounter difficulties. In this context, the development of objective diagnostic tools able to help healthcare professionals and women identify breastfeeding difficulties that could then be treated accordingly would seem an ideal solution. Previous studies have tried to provide evidence for the use of milk compositional variations during early lactation as a tool to identify delayed secretory activation of the mammary gland, which often results in impaired lactation. However, despite portable technology for this purpose being successfully developed and/or validated, a consistent research gap remains around the true diagnostic power of such biomarkers in relation to clinically significant outcomes. This obstructs the development of effective diagnostic tools that could be employed in clinical practice to improve breastfeeding outcomes and breastfeeding rates. CI - (c) 2025 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Galante, Laura AU - Galante L AUID- ORCID: 0000-0002-6190-7955 AD - Swansea University Medical School, Swansea, UK. FAU - Kobayashi, Eriko AU - Kobayashi E AUID- ORCID: 0000-0002-7211-1194 AD - Faculty of Nursing, Toyama Prefectural University, Toyama, Japan. FAU - Nishikawa, Miyu AU - Nishikawa M AD - Department of Biotechnology, Faculty of Engineering, Toyama Prefectural University, Toyama, Japan. AD - Division of Agriculture, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan. LA - eng PT - Journal Article PT - Review PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Breast Feeding/psychology MH - Female MH - *Lactation/physiology MH - Milk, Human/chemistry MH - Biomarkers/analysis MH - Infant, Newborn MH - *Lactation Disorders/diagnosis MH - Pregnancy PMC - PMC12699322 OTO - NOTNLM OT - breastfeeding difficulties OT - breastfeeding support OT - human milk OT - impaired lactation OT - lactation biomarkers OT - milk biomarkers OT - secretory activation COIS- The authors declare no conflicts of interest. EDAT- 2025/12/12 17:55 MHDA- 2025/12/12 17:56 PMCR- 2025/12/12 CRDT- 2025/12/12 06:32 PHST- 2025/11/13 00:00 [revised] PHST- 2025/06/12 00:00 [received] PHST- 2025/11/22 00:00 [accepted] PHST- 2025/12/12 17:56 [medline] PHST- 2025/12/12 17:55 [pubmed] PHST- 2025/12/12 06:32 [entrez] PHST- 2025/12/12 00:00 [pmc-release] AID - MCN70153 [pii] AID - 10.1111/mcn.70153 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Mar;22(1):e70153. doi: 10.1111/mcn.70153. PMID- 41384155 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251212 LR - 20251214 IS - 2532-8689 (Electronic) IS - 1124-9390 (Print) IS - 1124-9390 (Linking) VI - 33 IP - 4 DP - 2025 TI - High prevalence of dengue with warning signs but absence of severe cases in Vietnamese pediatric patients: an analysis of predictive factors. PG - 404-412 LID - 10.53854/liim-3304-5 [doi] AB - OBJECTIVES: To identify the prevalence and potential predictive factors of severe dengue among children in Vietnam. METHODS: A retrospective study was conducted at Thai Binh Pediatric Hospital, in children from 0 to 16 years, hospitalized for dengue infection from January 2023 to December 2024. Dengue severity was classified according to WHO 2009 guidelines. Potential predictive factors of severe disease were investigated using logistic regression. RESULTS: A total of 332 children hospitalized for dengue infection were included: median age was 14 months and male gender accounted for 63.0% of the patients. 15.1% (n=50) presented with dengue with warning sign (DWS). None of the children developed severe dengue. The mean time from symptom onset to diagnosis of DWS was 4.0 +/- 2.3 days. The most common clinical manifestations in DWS cases were right upper quadrant abdominal pain (34.0%), rapid decrease in platelet count (32.0%), and hepatomegaly (26.0%). Thrombocytopenia at admission was independent predictor (OR = 13.36, 95%CI [4.26-41.88]. Children older than five years and female patients also had higher odds of DWS (OR = 11.21, 95%CI [4.71-26.66] and OR = 2.32, 95%CI [1.05-5.13], respectively. Elevated hematocrit, hypoalbuminemia, elevated transaminases, abnormal nutritional status, petechiae and admission at >/= 4 days from symptom onset were not associated with DWS after adjustment. The model achieved a sensitivity of 74% and a specificity of 92%, corresponding to an area under the receiver-operating-characteristic curve of 0.83, giving an overall accuracy of 89.5%. CONCLUSIONS: Our findings identified predictive factors of DWS among children, especially low platelet count at admission is proposed as a practical tool for predicting DWS. This makes a practical tool for early risk stratification and resource allocation in settings with limited laboratory capacity in low- and middle-income countries. FAU - Le, Nhu Quynh AU - Le NQ AD - Thai Binh University of Medicine and Pharmacy, Hung Yen, Vietnam. FAU - Nguyen, Hai Anh AU - Nguyen HA AD - Thai Binh University of Medicine and Pharmacy, Hung Yen, Vietnam. FAU - Vu, Khanh Huyen AU - Vu KH AD - Thai Binh University of Medicine and Pharmacy, Hung Yen, Vietnam. FAU - Dang, Khanh Linh AU - Dang KL AD - Thai Binh University of Medicine and Pharmacy, Hung Yen, Vietnam. FAU - Hoang, Nang Trong AU - Hoang NT AD - Thai Binh University of Medicine and Pharmacy, Hung Yen, Vietnam. FAU - Dao, Thi Loi AU - Dao TL AD - Thai Binh University of Medicine and Pharmacy, Hung Yen, Vietnam. FAU - Hoang, Van Thuan AU - Hoang VT AD - Thai Binh University of Medicine and Pharmacy, Hung Yen, Vietnam. LA - eng PT - Journal Article DEP - 20251201 PL - Italy TA - Infez Med JT - Le infezioni in medicina JID - 9613961 PMC - PMC12695169 OTO - NOTNLM OT - Vietnam OT - children OT - dengue OT - dengue with warning sign OT - predictive factors COIS- Conflict of interest: The author declare that they have no conflict of interest. EDAT- 2025/12/12 07:19 MHDA- 2025/12/12 07:20 PMCR- 2025/12/01 CRDT- 2025/12/12 04:37 PHST- 2025/07/23 00:00 [received] PHST- 2025/09/17 00:00 [accepted] PHST- 2025/12/12 07:20 [medline] PHST- 2025/12/12 07:19 [pubmed] PHST- 2025/12/12 04:37 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - 1124-9390_33_4_2025_404-412 [pii] AID - 10.53854/liim-3304-5 [doi] PST - epublish SO - Infez Med. 2025 Dec 1;33(4):404-412. doi: 10.53854/liim-3304-5. eCollection 2025. PMID- 41383987 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251212 LR - 20251214 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 16 DP - 2025 TI - The effects of different exercise interventions on reducing internet addiction in adolescents or young adults: a systematic review and network meta-analysis. PG - 1713076 LID - 10.3389/fpsyt.2025.1713076 [doi] LID - 1713076 AB - BACKGROUND: Adolescents or young adults' physical and mental health, along with their academic performance, are negatively impacted by Internet addiction (IA), with such behavior being associated with the onset of cognitive and mental health disorders. Consequently, this issue has emerged as a pressing global social problem that demands urgent resolution. OBJECTIVE: This research employed a meta-analytic approach to systematically assess the efficacy of diverse exercise-based interventions in mitigating IA among university students. The primary objective was to determine optimal therapeutic exercise modalities and formulate evidence-based guidelines for subsequent intervention strategies targeting adolescent internet overuse. METHODS: A comprehensive systematic literature search was conducted across multiple international and domestic databases, including Web of Science, PubMed, Embase, Cochrane Library, China Knowledge, and Wanfang. Methodological quality was evaluated utilizing the revised Cochrane Risk of Bias tool for randomized trials. Subsequently, both conventional and network meta-analyses were performed employing Review Manager 5.3 and Stata 14.0 statistical software packages. RESULTS: Traditional meta-results showed that exercise intervention was better than the control group in improving adolescent IA (SMD= -2.33, 95%CI -3.00, -1.66). Network meta-analysis(NMA) showed that Combined movement (CM) improved adolescent IA better than Control group (CG) (SMD-3.47, 95% -4.85, -2.10), and CM had the highest probability of being the best intervention for IA (SUCRA = 86.7%). CONCLUSION: Exercise-based interventions demonstrate significant therapeutic efficacy in addressing IA, with CM exhibiting superior effectiveness for adolescent populations. Nevertheless, given the methodological limitations imposed by restricted sample sizes and heterogeneous literature quality, future large-scale randomized controlled trials are warranted to validate these preliminary findings. SYSTEMATIC REVIEW REGISTRATION: https://www.crd.york.ac.uk/prospero/, identifier CRD420251006694. CI - Copyright (c) 2025 Li, Zhong and Lian. FAU - Li, Ying AU - Li Y AD - College of Sports Science, Jishou University, Jishou, Hunan, China. FAU - Zhong, Songwei AU - Zhong S AD - School of Physical & Health Sciences, Guangxi Science & Technology Normal University, Laibin, Guangxi, China. FAU - Lian, Li AU - Lian L AD - Physical Education Department, Beijing Wuzi University, Beijing, China. LA - eng PT - Journal Article PT - Systematic Review DEP - 20251126 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC12690190 OTO - NOTNLM OT - IA OT - adolescents OT - internet addiction OT - network meta-analysis OT - teenagers COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/12 07:20 MHDA- 2025/12/12 07:21 PMCR- 2025/11/26 CRDT- 2025/12/12 04:35 PHST- 2025/09/25 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2025/12/12 07:21 [medline] PHST- 2025/12/12 07:20 [pubmed] PHST- 2025/12/12 04:35 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - 10.3389/fpsyt.2025.1713076 [doi] PST - epublish SO - Front Psychiatry. 2025 Nov 26;16:1713076. doi: 10.3389/fpsyt.2025.1713076. eCollection 2025. PMID- 41383326 OWN - NLM STAT- MEDLINE DCOM- 20251212 LR - 20251214 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Trends in physical fitness among polish children and adolescents. PG - 1576822 LID - 10.3389/fpubh.2025.1576822 [doi] LID - 1576822 AB - BACKGROUND: Human health, with physical fitness as one of its key indicators, is characterized by a dynamic nature. Therefore, monitoring motor abilities and the factors that influence them becomes particularly important. Recent studies on physical fitness trends among children and adolescents indicate a declining tendency, with a noticeable decrease in physical performance. Maintaining an optimal level of physical fitness in young individuals requires support not only from parents. Hence, health promotion policies should focus on fostering health-related physical fitness from early childhood. The aim of the current study was to determine physical fitness trends among Polish children and adolescents participating in the nationwide program "Athletics for All!" (AFA). An attempt was made to answer the question of whether the implementation of programs promoting physical activity among youth (as exemplified by the AFA program) has an impact on improving physical fitness and body build indicators as its markers. METHODS: Physical fitness was assessed in a group of 54,049 young individuals, including 31,789 girls and 22,260 boys, over eight consecutive years of the AFA program's implementation. The assessment was conducted using the OSF test, developed specifically for the AFA program, which includes a 3x10 m shuttle run, standing broad jump, 1 kg medicine ball throw, and a 4-min run. Statistical analyses were performed separately for each gender, assuming a significance level of alpha = 0.05. It was verified whether there were significant differences in the means between the groups distinguished based on the year of the study. RESULTS: The study results indicate that the implementation of the AFA program promoting physical activity among Polish youth has a positive impact on the improvement of physical fitness and body build parameters. Statistically significant differences were found in the mean values of measurements taken over the course of eight consecutive years. The results of multiple comparisons between the mean values of all the analyzed variables in different years revealed significant differences in most of the comparisons. CONCLUSION: The level of physical fitness among participants of the AFA program remained relatively stable over nearly a decade, which, in an era dominated by a sedentary lifestyle among modern youth, confirms the validity of implementing physical activity promotion programs (including the AFA program). CI - Copyright (c) 2025 Baj-Korpak, Zaworski, Wochna, Chmara and Stelmach. FAU - Baj-Korpak, Joanna AU - Baj-Korpak J AD - Department of Health Sciences, John Paul II University in Biala Podlaska, Biala Podlaska, Poland. FAU - Zaworski, Kamil AU - Zaworski K AD - Department of Health Sciences, John Paul II University in Biala Podlaska, Biala Podlaska, Poland. FAU - Wochna, Marek AU - Wochna M AD - Polish Athletics Association, Warsaw, Poland. FAU - Chmara, Sebastian AU - Chmara S AD - Polish Athletics Association, Warsaw, Poland. FAU - Stelmach, Marian J AU - Stelmach MJ AD - Department of Health Sciences, John Paul II University in Biala Podlaska, Biala Podlaska, Poland. LA - eng PT - Journal Article DEP - 20251126 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Poland MH - *Physical Fitness/physiology MH - Female MH - Adolescent MH - Male MH - Child MH - Exercise MH - *Health Promotion PMC - PMC12689887 OTO - NOTNLM OT - Body Mass Index OT - OSF test OT - Ponderal Index OT - adolescents OT - children OT - gender OT - physical fitness OT - trends COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/12 07:20 MHDA- 2025/12/12 07:21 PMCR- 2025/11/26 CRDT- 2025/12/12 04:25 PHST- 2025/02/17 00:00 [received] PHST- 2025/10/21 00:00 [revised] PHST- 2025/11/07 00:00 [accepted] PHST- 2025/12/12 07:21 [medline] PHST- 2025/12/12 07:20 [pubmed] PHST- 2025/12/12 04:25 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1576822 [doi] PST - epublish SO - Front Public Health. 2025 Nov 26;13:1576822. doi: 10.3389/fpubh.2025.1576822. eCollection 2025. PMID- 41383165 OWN - NLM STAT- MEDLINE DCOM- 20251212 LR - 20251230 IS - 2047-2986 (Electronic) IS - 2047-2978 (Print) IS - 2047-2978 (Linking) VI - 15 DP - 2025 Dec 12 TI - Analysing concordance between MUAC, MUACZ, and WHZ in diagnosing acute malnutrition among children under five in Somalia. PG - 04258 LID - 10.7189/jogh.15.04258 [doi] LID - 04258 AB - BACKGROUND: Acute malnutrition, also known as wasting, affected an estimated 45 million children under five (CU5) globally in 2023. Wasting is measured using a child's mid upper arm circumference (MUAC), weight-for-height z-score (WHZ), or nutritional oedema. In low-resource contexts, MUAC is often the only measurement used to regularly screen for malnutrition, but recent research suggests MUAC alone fails to diagnose 25-80% of WHZ-wasted children. Mid upper arm circumference, an age-adjusted MUAC z-score, may identify additional cases missed by MUAC alone. METHODS: This was a secondary analysis of 1408 CU5 enrolled in a cluster-randomised controlled trial in two high-wasting regions of Somalia. This analysis explored wasting prevalences, concordance between indicator pairs, linear regression modelling, and receiver operating characteristic (ROC) analysis using WHZ as a reference standard to examine alternative MUAC and MUACZ thresholds. RESULTS: Wasting prevalence was 1.5% by MUAC, 8.5% by MUACZ, and 14.8% by WHZ. Mid upper arm circumference alone failed to identify 94% of WHZ-wasted children. There was slight concordance between MUAC and WHZ (kappa (kappa) = 0.089) and fair concordance between MUACZ and WHZ (kappa = 0.385). Linear regression indicated that MUAC, age, sex, and stunting were all statistically significant variables for estimating child WHZ. Using WHZ as a reference standard, a MUAC of 13.7cm and MUACZ of -0.9 both accurately diagnosed >82% of wasted children ages 9-23 months. A MUAC of 14.4 cm and MUACZ of -1 both accurately diagnosed >76% of wasted children ages 24-59 months. CONCLUSIONS: Poor concordance between MUAC and WHZ should prompt review of wasting measurement guidelines for this population. Stratified analyses and regression modelling showed increased MUAC with age among CU5. MUACZ or age-specific MUAC thresholds may identify more truly wasted children, improving coverage of treatment interventions. Policymakers should examine how adapting screening guidelines impacts health facilities and treatment availability. Future studies should consider long-term outcomes and mortality associated with increased thresholds of MUAC and MUACZ. REGISTRATION: The cluster-RCT is registered at ClinicalTrials.gov, ID: NCT06642012. CI - Copyright (c) 2025 by the Journal of Global Health. All rights reserved. FAU - Garretson, Sydney AU - Garretson S AD - Johns Hopkins University, Department of International Health, Baltimore, Maryland, USA. FAU - Walton, Shelley AU - Walton S AD - Johns Hopkins University, Department of International Health, Baltimore, Maryland, USA. FAU - Alier, Kemish Kenneth AU - Alier KK AD - Johns Hopkins University, Department of International Health, Baltimore, Maryland, USA. FAU - Grounds, Samantha AU - Grounds S AD - Johns Hopkins University, Department of International Health, Baltimore, Maryland, USA. FAU - Khattak, Qundeel AU - Khattak Q AD - Save the Children International, London, UK. FAU - Mohamoud, Said Aden AU - Mohamoud SA AD - Save the Children Somalia, Mogadishu, Somalia. FAU - Farah, Abdullahi Abdulle AU - Farah AA AD - Save the Children International, London, UK. FAU - Mohamud, Farhan Mohamed AU - Mohamud FM AD - Federal Ministry of Health Somalia, Nutrition Section, Mogadishu, Somalia. FAU - Mohamoud, Abdullahi Muse AU - Mohamoud AM AD - Federal Ministry of Health Somalia, Nutrition Section, Mogadishu, Somalia. FAU - Mahdi, Adan AU - Mahdi A AD - Save the Children Somalia, Mogadishu, Somalia. FAU - Ismail, Meftuh Omer AU - Ismail MO AD - Save the Children Somalia, Mogadishu, Somalia. FAU - Mahat, Mohamed Billow AU - Mahat MB AD - Save the Children Somalia, Mogadishu, Somalia. FAU - Loddo, Fabrizio AU - Loddo F AD - Save the Children International, London, UK. FAU - Tripaldi, Marina AU - Tripaldi M AD - Save the Children International, London, UK. FAU - Akseer, Nadia AU - Akseer N AD - Johns Hopkins University, Department of International Health, Baltimore, Maryland, USA. LA - eng SI - ClinicalTrials.gov/NCT06642012 PT - Journal Article PT - Randomized Controlled Trial DEP - 20251212 PL - Scotland TA - J Glob Health JT - Journal of global health JID - 101578780 SB - IM MH - Humans MH - Somalia/epidemiology MH - Infant MH - Male MH - Child, Preschool MH - Female MH - *Arm/anatomy & histology MH - *Anthropometry/methods MH - Prevalence MH - Body Height MH - *Wasting Syndrome/diagnosis/epidemiology MH - Body Weight MH - *Child Nutrition Disorders/diagnosis/epidemiology PMC - PMC12699285 COIS- Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests. EDAT- 2025/12/12 07:20 MHDA- 2025/12/12 07:21 PMCR- 2025/12/12 CRDT- 2025/12/12 04:03 PHST- 2025/12/12 07:21 [medline] PHST- 2025/12/12 07:20 [pubmed] PHST- 2025/12/12 04:03 [entrez] PHST- 2025/12/12 00:00 [pmc-release] AID - jogh-15-04258 [pii] AID - 10.7189/jogh.15.04258 [doi] PST - epublish SO - J Glob Health. 2025 Dec 12;15:04258. doi: 10.7189/jogh.15.04258. PMID- 41382306 OWN - NLM STAT- MEDLINE DCOM- 20260115 LR - 20260117 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2025 Dec 11 TI - Placental proteomic signatures of preterm birth, gestational age, and birthweight. PG - 50 LID - 10.1186/s12884-025-08558-0 [doi] LID - 50 AB - BACKGROUND: Preterm birth and low birthweight are leading contributors to infant morbidity and mortality, yet underlying mechanisms remain poorly understood. Proteomics can provide insights into biological pathways that may be targets for prevention and reveal predictive markers of at-risk pregnancies. The placenta plays a critical role in parturition, yet few studies have investigated proteomic signatures in the placenta associated with birth outcomes. METHODS: Using untargeted, mass spectrometry-based label-free proteomics, 1,221 proteins were quantified in placental samples from 99 participants in the Conditions Affecting Neurocognitive Development and Learning in Early Childhood (CANDLE) study. Associations of placental proteomics with binary spontaneous preterm birth, continuous gestational age at birth, and birthweight-for-gestational age z-scores were evaluated via differential abundance analysis, pathway enrichment, and principal component analysis (PCA) adjusting for numerous potential confounders. Sparse partial least squares discriminant analysis (sPLS-DA) was employed in a classification analysis to predict preterm versus term birth using the placental proteomics data. RESULTS: Preterm birth was associated with expression of 295 proteins and 15 molecular pathways, while gestational age was associated with expression of 367 proteins and 28 molecular pathways. Among the proteins significantly associated with either outcome, 264 (72%) overlapped. Proteins most strongly associated with both birth timing measures included Steryl-sulfatase (STS; preterm birth: LogFC = 2.08, FDR < 0.0001; gestational age at birth: LogFC= -0.57, FDR < 0.000001) and Collagen alpha-2(I) chain (COL1A2; preterm birth: LogFC= -2.11, FDR < 0.001; gestational age at birth: LogFC = 0.49, FDR < 0.0001). No associations were identified with birthweight z-scores. Proteins with the strongest links to preterm birth were major contributors to variance explained in PCA, and four of ten retained PCs were significantly associated with preterm birth. The top component in sPLS-DA classified preterm birth with 86.9% accuracy using 30 proteins, while the optimal sPLS-DA solution retaining three components classified preterm birth with 87.7% accuracy using 120 proteins. CONCLUSIONS: Many of the top proteins and molecular pathways associated with birth timing measures have been previously implicated in birth outcomes and pregnancy complications, and point to mechanisms including energy production, inflammation, and oxidative stress that may drive these risks. These proteins may serve as targets in future mechanistic and therapeutic research. Proteins identified through sPLS-DA demonstrated high accuracy in distinguishing preterm from term birth, pointing to potential targets for clinical screening tools, but necessitating validation in independent studies and more accessible biospecimens. CI - (c) 2025. The Author(s). FAU - Baker, Brennan H AU - Baker BH AD - University of Washington, Seattle, WA, USA. bbaker26@uw.edu. AD - Seattle Children's Research Institute, Seattle, WA, USA. bbaker26@uw.edu. FAU - Kruger, Laken AU - Kruger L AD - Department of Pharmaceutical Sciences, Washington State University, Spokane, WA, USA. FAU - Prasad, Bhagwat AU - Prasad B AD - Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. FAU - MacDonald, James W AU - MacDonald JW AD - University of Washington, Seattle, WA, USA. FAU - Bammler, Theo K AU - Bammler TK AD - University of Washington, Seattle, WA, USA. FAU - Konwar, Chaini AU - Konwar C AD - University of British Columbia, Vancouver, BC, Canada. FAU - Kobor, Michael S AU - Kobor MS AD - University of British Columbia, Vancouver, BC, Canada. FAU - Bush, Nicole R AU - Bush NR AD - University of California San Francisco, San Francisco, CA, USA. FAU - LeWinn, Kaja Z AU - LeWinn KZ AD - University of California San Francisco, San Francisco, CA, USA. FAU - Zhao, Qi AU - Zhao Q AD - University of Tennessee Health Science Center, Memphis, TN, USA. FAU - Paquette, Alison G AU - Paquette AG AD - University of Washington, Seattle, WA, USA. AD - Seattle Children's Research Institute, Seattle, WA, USA. FAU - Sathyanarayana, Sheela AU - Sathyanarayana S AD - University of Washington, Seattle, WA, USA. AD - Seattle Children's Research Institute, Seattle, WA, USA. LA - eng GR - UG3OD023271 /UH3OD03271/NIH Office of the Director/ GR - UL1TR002319/TR/NCATS NIH HHS/United States GR - P30ES007033/ES/NIEHS NIH HHS/United States GR - P30 ES007033/ES/NIEHS NIH HHS/United States GR - UL1 TR002319/TR/NCATS NIH HHS/United States GR - T32ES015459/ES/NIEHS NIH HHS/United States GR - UG3 OD023271/OD/NIH HHS/United States GR - T32 ES015459/ES/NIEHS NIH HHS/United States GR - R01 ES033785/ES/NIEHS NIH HHS/United States GR - R01ES033785/ES/NIEHS NIH HHS/United States PT - Journal Article DEP - 20251211 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - 0 (Biomarkers) RN - 0 (Proteome) SB - IM MH - Humans MH - Female MH - Pregnancy MH - *Premature Birth/metabolism MH - *Placenta/metabolism MH - *Gestational Age MH - Proteomics/methods MH - Infant, Newborn MH - *Birth Weight MH - Adult MH - Biomarkers/metabolism MH - *Proteome PMC - PMC12801428 COIS- Declarations. Ethics approval and consent to participate: Participants aged 18 years or older provided informed consent, while assent and consent from legally authorized representatives were obtained for those under 18 years prior to enrollment. This study was approved by the institutional review boards at the University of Tennessee Health Science Center and the University of Washington, and adhered to the principles for medical research involving human participants as outlined in the Helsinki Declaration. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/12 03:28 MHDA- 2026/01/15 07:55 PMCR- 2025/12/11 CRDT- 2025/12/11 23:46 PHST- 2025/09/16 00:00 [received] PHST- 2025/12/03 00:00 [accepted] PHST- 2026/01/15 07:55 [medline] PHST- 2025/12/12 03:28 [pubmed] PHST- 2025/12/11 23:46 [entrez] PHST- 2025/12/11 00:00 [pmc-release] AID - 10.1186/s12884-025-08558-0 [pii] AID - 8558 [pii] AID - 10.1186/s12884-025-08558-0 [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2025 Dec 11;26(1):50. doi: 10.1186/s12884-025-08558-0. PMID- 41382146 OWN - NLM STAT- MEDLINE DCOM- 20260115 LR - 20260116 IS - 1472-6920 (Electronic) IS - 1472-6920 (Linking) VI - 26 IP - 1 DP - 2025 Dec 11 TI - Critical thinking gamification in medical education. PG - 90 LID - 10.1186/s12909-025-08446-3 [doi] LID - 90 AB - BACKGROUND: Advancements in health and medical education are key to a promising future, but sustaining their exponential pace requires innovative approaches. Gamification offers a powerful tool to foster engagement and enhance the educational journey of medical professionals. By integrating interactive and motivational elements into training, gamification not only boosts knowledge acquisition but also addresses the monotony of traditional methods, encouraging deeper cognitive engagement and reducing errors in practice. Critical thinking is essential for accurate and timely medical decisions, particularly in diagnosing new patients at emergency department. Enhancing these skills can significantly reduce errors and improve patient outcomes, including lowering mortality rates. METHODS: This project introduces a critical thinking game designed to improve the clinical reasoning skills of pediatric students before they enter the field. The game simulates realistic clinical cases, where students draw randomized cards presenting patient profiles, symptoms, and test results, then race against the clock to deliver most relevant diagnoses and actions. The game employs a Case-Based Morning Report format designed to provide hands-on learning experiences. The gameplay involves three cards presented to students, each containing different types of medical information: a patient's description, their symptoms, and their examination results. Based on this data, students must create a diagnostic scenario and discuss it with a licensed pediatrician, who serves as the moderator. The moderator ultimately determines the best scenario based on logical reasoning and medical accuracy. The moderator is always an expert in the domain and a university professor, which already ensures a high level of reliability. In addition, we conducted a single-arm, exploratory pilot study with undergraduate medical students (n = 100) from first to fourth year (Med1-Med4) at the Holy Spirit University of Kaslik (USEK). Participants engaged with the DMRCT platform during scheduled sessions. After gameplay, they completed a structured Likert-scale survey measuring perceived critical thinking improvement, engagement, interface usability, and competitive pressure. Objective gameplay metrics (reaction time, diagnostic accuracy, number of errors) were recorded automatically by the platform's backend. This problem-based learning approach fosters excitement, interactivity, and competitiveness, transforming critical training into an engaging experience. RESULTS: Our multiplayer educational game is hosted on a web-based platform, enabling students to engage in critical thinking exercises remotely. The participants in each session consist of two opposing teams of medical students, who analyze and discuss the case information before presenting their scenarios. The moderator evaluates the scenarios and awards points based on the accuracy and reasoning presented. Our critical thinking game was tested with 100 medical students (Med1-Med4) through randomized clinical scenarios. Feedback revealed that students viewed the game as a valuable complement to traditional morning rounds, enhancing diagnostic synthesis, problem-solving, and decision-making, particularly for advanced learners. Students reported increased motivation, teamwork, and the ability to practice decision-making in a low-risk environment. Technical evaluations confirmed the platform's reliability, real-time scoring, and analytics integration, with pilot sessions showing active participation, multiple valid diagnoses, and meaningful moderator-student interactions that deepened clinical reasoning skills. CONCLUSION: By immersing students in dynamic, field-relevant scenarios, our critical thinking game enriches analytical reasoning, problem-solving abilities, and clinical judgment. Transforming education into an interactive, game-based experience cultivates skilled, confident practitioners prepared to meet the complex challenges of real-world pediatric care. The pilot evaluation among medical students revealed high engagement, improved diagnostic accuracy, and a positive perception of clinical reasoning development. CI - (c) 2025. The Author(s). FAU - Fadous, Marie Claude AU - Fadous MC AD - School of Medicine and Medical Sciences, Holy Spirit University of Kaslik, USEK,, KASLIK Jounieh, Lebanon. AD - Notre Dame des Secours, University Hospital, Byblos, Lebanon. AD - ResoSante C-B-Sante Ouest CHC , Montreal, Canada. FAU - Zeeny, Charbel AU - Zeeny C AD - School of Engineering, Holy Spirit University of Kaslik, USEK, KASLIK, Jounieh, Lebanon. FAU - Cheiban, Kenneth AU - Cheiban K AD - School of Medicine and Medical Sciences, Holy Spirit University of Kaslik, USEK,, KASLIK Jounieh, Lebanon. FAU - Margossian, Garo AU - Margossian G AD - School of Engineering, Holy Spirit University of Kaslik, USEK, KASLIK, Jounieh, Lebanon. FAU - Ghorayeb, Zaki AU - Ghorayeb Z AD - School of Medicine and Medical Sciences, Holy Spirit University of Kaslik, USEK,, KASLIK Jounieh, Lebanon. AD - Notre Dame des Secours, University Hospital, Byblos, Lebanon. FAU - Massoud, Chadi AU - Massoud C AD - School of Engineering, Holy Spirit University of Kaslik, USEK, KASLIK, Jounieh, Lebanon. chadimassoud@usek.edu.lb. AD - Faculty of Public Health, Universite La Sagesse, Furn el Chebbak , Lebanon. chadimassoud@usek.edu.lb. FAU - Rihana, Sandy AU - Rihana S AD - School of Engineering, Holy Spirit University of Kaslik, USEK, KASLIK, Jounieh, Lebanon. sandyrihana@usek.edu.lb. LA - eng PT - Journal Article DEP - 20251211 PL - England TA - BMC Med Educ JT - BMC medical education JID - 101088679 SB - IM MH - Humans MH - *Thinking MH - *Pediatrics/education MH - Clinical Competence MH - Students, Medical/psychology MH - *Clinical Reasoning MH - *Education, Medical/methods PMC - PMC12801931 OTO - NOTNLM OT - Critical thinking OT - Gamification OT - Medical education OT - Online education COIS- Declarations. Ethics approval and consent to participate: This study was reviewed by the Research Ethics Committee of the Holy Spirit University of Kaslik (USEK), Lebanon. It was deemed exempt from formal ethical approval as it did not involve identifiable personal data, clinical intervention, or biological materials. The research was conducted as part of an undergraduate biomedical engineering capstone project and was limited to simulated educational scenarios involving volunteer student participants. The study was carried out in accordance with the ethical principles of the Declaration of Helsinki (2013 revision) and the academic research guidelines of USEK. All participants were informed of the study's educational purpose and voluntarily gave their verbal informed consent prior to taking part in the testing sessions. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/12 03:29 MHDA- 2026/01/15 07:55 PMCR- 2025/12/11 CRDT- 2025/12/11 23:40 PHST- 2025/07/04 00:00 [received] PHST- 2025/12/08 00:00 [accepted] PHST- 2026/01/15 07:55 [medline] PHST- 2025/12/12 03:29 [pubmed] PHST- 2025/12/11 23:40 [entrez] PHST- 2025/12/11 00:00 [pmc-release] AID - 10.1186/s12909-025-08446-3 [pii] AID - 8446 [pii] AID - 10.1186/s12909-025-08446-3 [doi] PST - epublish SO - BMC Med Educ. 2025 Dec 11;26(1):90. doi: 10.1186/s12909-025-08446-3. PMID- 41381992 OWN - NLM STAT- MEDLINE DCOM- 20260612 LR - 20261010 IS - 2038-3312 (Electronic) IS - 2038-131X (Linking) VI - 78 IP - 3 DP - 2026 Jun TI - The impact of early stoma closure on infants after surgery for necrotizing enterocolitis (NEC): real-world data analysis. PG - 1143-1151 LID - 10.1007/s13304-025-02468-8 [doi] AB - To evaluate the impact of early (< 8 weeks) versus late (>/= 8 weeks) stoma closure on postoperative recovery and complications in preterm infants following surgery for necrotizing enterocolitis (NEC). In this multicenter retrospective cohort study, we analyzed data from preterm infants who underwent stoma closure between 2011 and 2022. Propensity score matching (PSM) was applied in a 1:2 ratio to balance baseline characteristics between early and late closure groups. Outcomes assessed included stoma-related complications, operative characteristics, gastrointestinal recovery, and postoperative complications. Of 367 eligible infants, 80 in the early closure group and 186 in the late closure group were included after matching. Baseline characteristics were well-balanced. The early closure group had significantly lower median weight at closure (2674 g vs. 3374 g, p = 0.038) and shorter stoma duration (48 vs. 69 days, p = 0.0064). Time to first flatus/defecation was shorter in the early group (2.7 +/- 1.8 days vs. 3.2 +/- 1.9 days, p = 0.012). There were no significant differences in overall complication rates, reoperation, readmission, mortality, duration of parenteral nutrition, or hospital stay. A non-significant trend toward higher median weight at 6 months corrected age was observed in the early group (6548 g vs. 6287 g, p = 0.12). Early stoma closure (< 8 weeks) is associated with faster recovery of gastrointestinal function and does not increase the risk of postoperative complications. These findings support the feasibility and safety of early closure in selected NEC infants, though timing should be individualized based on clinical assessment. CI - (c) 2025. Italian Society of Surgery (SIC). FAU - Li, Fang AU - Li F AD - Operating Room and Anesthesiology Department, Chongqing health center for women and children, Chongqing Medical University, Chongqing, People's Republic of China. AD - Department of Pediatrics, Women and Children's Hospital, Chongqing Medical University, 120 Longshan Rd., Chongqing, 401147, People's Republic of China. FAU - Chen, Guoqiang AU - Chen G AD - Department of Pediatrics, Women and Children's Hospital, Chongqing Medical University, 120 Longshan Rd., Chongqing, 401147, People's Republic of China. AD - Department of Pediatrics, Chongqing health center for women and children, Chongqing Medical University, 120 Longshan Rd., Chongqing, 401147, People's Republic of China. FAU - Bao, Chunli AU - Bao C AD - Department of Pediatrics, Women and Children's Hospital, Chongqing Medical University, 120 Longshan Rd., Chongqing, 401147, People's Republic of China. guochunbao@hospital.cqmu.edu.cn. AD - Department of Pediatrics, Chongqing health center for women and children, Chongqing Medical University, 120 Longshan Rd., Chongqing, 401147, People's Republic of China. guochunbao@hospital.cqmu.edu.cn. FAU - Guo, Chunbao AU - Guo C AUID- ORCID: 0000-0001-5121-9377 AD - Operating Room and Anesthesiology Department, Chongqing health center for women and children, Chongqing Medical University, Chongqing, People's Republic of China. guochunbao@foxmail.com. AD - Department of Pediatrics, Women and Children's Hospital, Chongqing Medical University, 120 Longshan Rd., Chongqing, 401147, People's Republic of China. guochunbao@foxmail.com. AD - Department of Pediatrics, Chongqing health center for women and children, Chongqing Medical University, 120 Longshan Rd., Chongqing, 401147, People's Republic of China. guochunbao@foxmail.com. LA - eng PT - Journal Article PT - Multicenter Study DEP - 20251211 PL - Italy TA - Updates Surg JT - Updates in surgery JID - 101539818 SB - IM MH - Humans MH - *Enterocolitis, Necrotizing/surgery MH - Retrospective Studies MH - Infant, Newborn MH - Postoperative Complications/epidemiology MH - Male MH - Female MH - Propensity Score MH - *Surgical Stomas MH - Time Factors MH - Infant, Premature MH - Treatment Outcome OTO - NOTNLM OT - Necrotizing enterocolitis OT - Postoperative outcomes OT - Preterm infants OT - Propensity score matching OT - Stoma closure COIS- Declarations. Conflict of interest: No financial or non-financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article. Ethical approval: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Children's Hospital of Chongqing Medical University. EDAT- 2025/12/12 03:29 MHDA- 2026/06/12 00:39 CRDT- 2025/12/11 23:36 PHST- 2025/08/13 00:00 [received] PHST- 2025/11/10 00:00 [accepted] PHST- 2026/06/12 00:39 [medline] PHST- 2025/12/12 03:29 [pubmed] PHST- 2025/12/11 23:36 [entrez] AID - 10.1007/s13304-025-02468-8 [pii] AID - 10.1007/s13304-025-02468-8 [doi] PST - ppublish SO - Updates Surg. 2026 Jun;78(3):1143-1151. doi: 10.1007/s13304-025-02468-8. Epub 2025 Dec 11. PMID- 41381180 OWN - NLM STAT- MEDLINE DCOM- 20261007 LR - 20261007 IS - 1468-3288 (Electronic) IS - 0017-5749 (Linking) VI - 75 IP - 11 DP - 2026 Oct 7 TI - Preclinical stages of Crohn's disease defined by faecal calprotectin in asymptomatic first-degree relatives: screening framework for prevention trials. PG - 2225-2231 LID - 10.1136/gutjnl-2025-336368 [doi] AB - BACKGROUND: The PIONIR (Preventing IBD ONset in Individuals at Risk) trial evaluates whether the Tasty&Healthy diet can reduce risk of Crohn's disease (CD) development in first-degree relatives (FDRs). The optimal preclinical stage of CD for enrolling subjects to prevention trials is unknown. OBJECTIVES: We aimed to propose a framework for identifying high-risk participants for prevention trials by reporting the outcomes of the pre-PIONIR screening stage. DESIGN: Faecal calprotectin was measured in asymptomatic FDRs aged 6-38 years; those with persistent elevation, defined as >70 microg/g in at least two separate tests, were offered panenteric video capsule-endoscopy or ileocolonoscopy. RESULTS: Of 950 FDRs approached, 331 (35%) agreed to be screened: 63 (19%) had persistently elevated calprotectin, of whom 42 underwent further evaluation. Nine (2.7%) had endoscopic appearance compatible with presymptomatic CD, 22 (6.6%) had non-specific macroscopic mucosal changes and 11 (3.3%) had normal mucosa despite elevated calprotectin, suggesting probable histological inflammation. The 33 participants in the two latter groups were defined as 'potential pre-CD' (17.9% of all screened after adjusting for missing values). Calprotectin >225 microg/g predicted presymptomatic CD (area under the receiver operating characteristic curve 0.97 (95% CI 0.94 to 1.0; p<0.001; sensitivity 89%, specificity 94%). Of those with a single elevated calprotectin value, 22% normalised on repeat testing with significant variability (intraclass correlation coefficient 0.72 (95% CI 0.57 to 0.82)). CONCLUSION: Approximately one in five asymptomatic FDRs had persistently elevated calprotectin, which was able to differentiate those with presymptomatic CD. The findings highlight calprotectin's utility in identifying at-risk individuals during the potential pre-CD stage for enrolment in prevention trials. CI - (c) Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Turner, Dan AU - Turner D AUID- ORCID: 0000-0001-5160-868X AD - Institute of Pediatric Gastroenterology, Shaare Zedek Medical Center, Jerusalem, Jerusalem District, Israel turnerd@szmc.org.il. AD - Hebrew University of Jerusalem Faculty of Medicine, Jerusalem, Jerusalem District, Israel. FAU - Kenigsberg, Sarah AU - Kenigsberg S AD - Shaare Zedek Medical Center, Jerusalem, Jerusalem District, Israel. FAU - Focht, Gili AU - Focht G AD - The Juliet Keiden Institute of Pediatric Gastroenterology and Nutrition, Shaare Zedek Medical Center, Jerusalem, Israel. FAU - Turpin, Williams AU - Turpin W AD - Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada. AD - Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. FAU - Ledder, Oren AU - Ledder O AUID- ORCID: 0000-0001-8109-814X AD - Paediatric Gastroenterology, Shaare Zedek Medical Center, Jerusalem, Israel. AD - Hebrew University Faculty of Medicine, Jerusalem, Israel. FAU - Griffiths, Anne M AU - Griffiths AM AD - Department of Paediatrics, University of Toronto, Division of Gastroenterology, Hepatology & Nutrition, The Hospital for Sick Children, Toronto, Ontario, Canada. FAU - Huynh, Hien Q AU - Huynh HQ AD - Michael J. Howorth GEM Project Team, Toronto, Ontario, Canada. FAU - Plotkin, Luba AU - Plotkin L AD - Shaare Zedek Medical Center Juliet Keidan Institute of Paediatric Gastroenterology and Nutrition, Jerusalem, Israel. FAU - Aharoni-Frutkoff, Yonat AU - Aharoni-Frutkoff Y AD - Shaare Zedek Medical Center, Jerusalem, Jerusalem District, Israel. FAU - El-Matary, Wael AU - El-Matary W AD - Pediatric Gastroenterology, University of Manitoba, Winnipeg, Manitoba, Canada. FAU - Otley, Anthony R AU - Otley AR AD - Pediatric Gastroenterology and Nutrition, IWK Health Centre, Halifax, Nova Scotia, Canada. FAU - Avni-Biron, Irit AU - Avni-Biron I AD - Division of Gastroenterology, Rabin Medical Center, Petah Tikva, Central, Israel. FAU - Jacobson, Kevan AU - Jacobson K AUID- ORCID: 0000-0001-7269-8557 AD - Pediatrics, British Columbia Children's Hospital, Vancouver, British Columbia, Canada. FAU - Panaccione, Remo AU - Panaccione R AD - Medicine, University of Calgary, Calgary, Alberta, Canada. FAU - Torres, Joana AU - Torres J AUID- ORCID: 0000-0003-2895-5821 AD - GI, Mount Sinai School of Medicine, New York City, New York, USA. FAU - Lee, Sun-Ho AU - Lee SH AUID- ORCID: 0000-0003-0344-0047 AD - Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Toronto, Ontario, Canada. AD - Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. FAU - Croitoru, Kenneth AU - Croitoru K AD - Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada. AD - Division of Gastroenterology & Hepatology, Temerty Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. LA - eng PT - Journal Article DEP - 20261007 PL - England TA - Gut JT - Gut JID - 2985108R RN - 0 (Leukocyte L1 Antigen Complex) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Leukocyte L1 Antigen Complex/analysis MH - *Crohn Disease/diagnosis/prevention & control MH - *Feces/chemistry MH - Female MH - Male MH - Child MH - Adolescent MH - Adult MH - Biomarkers/analysis MH - Young Adult MH - Colonoscopy MH - Family MH - Capsule Endoscopy MH - Mass Screening/methods OTO - NOTNLM OT - CROHN'S DISEASE OT - IBD CLINICAL OT - SCREENING COIS- Competing interests: DT, SK, HH, WE, LP, YA-F, AMG, IA-B, OL, GF, WT and KC declare no conflicts in relation to the content of this study. KJ: Advisory board (AbbVie, McKesson Canada, Janssen, Viatris, Celltrion; CSL Behring Canada); Speaker's bureau (AbbVie). JT: Research support from AbbVie and Johnson & Johnson; has received advisory board/speaker fees from Eli Lilly, AbbVie, Johnson & Johnson, Pfizer, Sandoz and Tillots Pharma. RP: Consultant for Abbott, AbbVie, Abbivax, Alimentiv, Amgen, AnaptysBio, AstraZeneca, Biogen, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Celltrion, Cosmos Pharmaceuticals, Eisai, Elan, Eli Lilly, Ferring, Galapagos, Inviva, Fresenius Kabi, Genentech, Gilead Sciences, Glaxo-Smith Kline, JAMP Bio, Janssen, Merck, Mirador, Novartis, Oppilan Pharma, Odyssey, Organon, Pandion Pharma, Pendopharm, Pfizer, Progenity, Prometheus Biosciences, Protagonist Therapeutics, Roche, Sandoz, Sanofi, Satisfai Health, Shire, Sublimity Therapeutics, Spyre Therapeutics, Takeda Pharmaceuticals, Teva, Tillots, Trellus, Union Biopharma, Viatris, Ventyx, UCB; Speaker's fees for AbbVie, Amgen, Arena Pharmaceuticals, Bristol-Myers Squibb, Celgene, Eli Lilly, Ferring, Fresenius Kabi, Gilead Sciences, Janssen, Merck, Organon, Pfizer, Roche, Sandoz, Shire, Takeda Pharmaceuticals; Advisory Boards for AbbVie, Alimentiv (formerly Robarts), Amgen, Arena Pharmaceuticals, AstraZeneca, Biogen, Boehringer Ingelheim, Bristol-Myers Squibb, Celgene, Eli Lilly, Ferring, Fresenius Kabi, Genentech, Gilead Sciences, Glaxo-Smith Kline, JAMP Bio, Janssen, Merck, Mylan, Novartis, Oppilan Pharma, Organon, Pandion Pharma, Pfizer, Progenity, Protagonist Therapeutics, Roche, Sandoz, Sanofi, Sublimity Therapeutics, Takeda Pharmaceuticals, Ventyx. EDAT- 2025/12/12 03:28 MHDA- 2026/10/07 23:30 CRDT- 2025/12/11 21:02 PHST- 2025/07/10 00:00 [received] PHST- 2025/12/01 00:00 [accepted] PHST- 2026/10/07 23:30 [medline] PHST- 2025/12/12 03:28 [pubmed] PHST- 2025/12/11 21:02 [entrez] AID - gutjnl-2025-336368 [pii] AID - 10.1136/gutjnl-2025-336368 [doi] PST - epublish SO - Gut. 2026 Oct 7;75(11):2225-2231. doi: 10.1136/gutjnl-2025-336368. PMID- 41380645 OWN - NLM STAT- MEDLINE DCOM- 20260121 LR - 20260713 IS - 1365-229X (Electronic) IS - 0009-9260 (Linking) VI - 92 DP - 2026 Jan TI - Assessment of pancreatic volumes and secretory function by magnetic resonance cholangiopancreatography (MRCP) in children with suspected exocrine pancreatic insufficiency. PG - 107136 LID - S0009-9260(25)00341-1 [pii] LID - 10.1016/j.crad.2025.107136 [doi] AB - AIM: Exocrine pancreatic insufficiency (EPI) can be assessed noninvasively using magnetic resonance cholangiopancreatography (MRCP) with secretin stimulation. This pilot study measured pancreatic volumes in children with suspected EPI and quantified total secreted fluid volume after secretin stimulation. MATERIALS AND METHODS: We retrospectively reviewed MRCPs performed between 2011 and 2021. Pancreatic volume was quantified using parametric magnetic resonance imaging (MRI) software on axial T2-weighted images. Secreted volume after secretin administration was measured with regions of interest on coronal single-shot fast spin echo (SSFSE) thick-slab sequences including thresholded pixels in the stomach and small intestine. RESULTS: We included 44 scans from 39 patients (23 males) in the study with a mean patient age of 10.7 +/- 5.1 years. Median pancreas volume was 27.43 mL (interquartile range [IQR]: 15.92-53.51 mL). Pancreas volume correlated significantly with patient weight (Spearman's rho = 0.63; P<0.001), height (rho = 0.63; P<0.001), and body surface area (BSA) (rho = 0.64; P<0.001). Median total secreted fluid volume after secretin was 71.35 mL (IQR: 31.77-119.56 mL). There was no statistically significant correlation of total secreted volume with patient age, weight, weight percentile, height percentile, body mass index (BMI), BMI percentile, or BSA (P>0.05). CONCLUSION: We report MRCP-derived pancreas volumes and total secreted fluid volumes in a cohort of children undergoing clinically indicated MRCP. Our study demonstrates the feasibility of obtaining such measures using MRI as a noninvasive tool. Pancreas volume correlated strongly with body size (weight, height, and BSA) and moderately with patient age, height percentile, and BMI. In contrast, total secreted volume showed no correlation with demographic or anthropometric measures. CI - Copyright (c) 2025 The Royal College of Radiologists. Published by Elsevier Ltd. All rights reserved. FAU - Venkatakrishna, S S B AU - Venkatakrishna SSB AD - Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, US. Electronic address: shyamvenkatakrishna@gmail.com. FAU - Onyango, L C AU - Onyango LC AD - Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, US; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, US. FAU - Acord, M R AU - Acord MR AD - Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, US; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, US. FAU - Srinivasan, A S AU - Srinivasan AS AD - Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, US; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, US. FAU - Lerebo, W T AU - Lerebo WT AD - Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, US. FAU - Khrichenko, D AU - Khrichenko D AD - Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, US. FAU - Maqbool, A AU - Maqbool A AD - Division of Gastroenterology, Hepatology, and Nutrition, Children's Hospital of Philadelphia, PA, US; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, US. FAU - Anupindi, S A AU - Anupindi SA AD - Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, US; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, US. FAU - Serai, S D AU - Serai SD AD - Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, US; Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, US. LA - eng PT - Journal Article DEP - 20251017 PL - England TA - Clin Radiol JT - Clinical radiology JID - 1306016 RN - 1393-25-5 (Secretin) SB - IM MH - Humans MH - Male MH - Child MH - Female MH - *Cholangiopancreatography, Magnetic Resonance/methods MH - Retrospective Studies MH - *Exocrine Pancreatic Insufficiency/diagnostic imaging/pathology/physiopathology MH - Pilot Projects MH - Adolescent MH - *Pancreas/diagnostic imaging/pathology MH - Organ Size MH - Secretin MH - Child, Preschool COIS- Conflict of Interest The authors declare no conflict of interest. EDAT- 2025/12/12 03:28 MHDA- 2026/01/22 01:09 CRDT- 2025/12/11 18:11 PHST- 2025/01/10 00:00 [received] PHST- 2025/10/12 00:00 [revised] PHST- 2025/10/15 00:00 [accepted] PHST- 2026/01/22 01:09 [medline] PHST- 2025/12/12 03:28 [pubmed] PHST- 2025/12/11 18:11 [entrez] AID - S0009-9260(25)00341-1 [pii] AID - 10.1016/j.crad.2025.107136 [doi] PST - ppublish SO - Clin Radiol. 2026 Jan;92:107136. doi: 10.1016/j.crad.2025.107136. Epub 2025 Oct 17. PMID- 41380455 OWN - NLM STAT- MEDLINE DCOM- 20260102 LR - 20261021 IS - 1872-8243 (Electronic) IS - 1386-5056 (Linking) VI - 207 DP - 2026 Mar 1 TI - Disability pension during emerging adulthood: Insights from the young-HUNT study on psychological distress, chronic pain, and policy reform. PG - 106216 LID - S1386-5056(25)00433-2 [pii] LID - 10.1016/j.ijmedinf.2025.106216 [doi] AB - INTRODUCTION: Disability pension (DP) among young adults has steadily increased in Norway, with chronic pain and psychological distress among the main causes. This study examined the association between co-occurring psychological distress and chronic pain in adolescence and the risk of DP during emerging adulthood, before and after the Norwegian Labour and Welfare Administration (NAV) reform. Machine learning survival models were also developed to predict early DP and identify consistent risk factors across cohorts. METHODS: Data from two general population surveys in 1995-1997 (Young-HUNT1) and 2006-2008 (Young-HUNT3) were linked to public registry data for DP, with a mean follow-up of 12 years. These represent populations pre- and post-NAV reform, respectively. Crude and adjusted Cox proportional hazards models tested associations between chronic pain, psychological distress and their co-occurrence with early DP. Machine learning survival models were developed using common predictors across cohorts and validated temporally. SurvSHAP(t) and hazard ratios were used for explainable risk factor analysis. RESULTS: Co-occurring psychological distress and chronic pain were associated with increased early DP risk in Young-HUNT3 (HR = 2.25, [95 % CI 1.62 to 3.14]) but not in Young-HUNT1. Tree-based machine learning models showed strong predictive performance and generalizability over time, with ExtraSurvivalTrees achieving a validation c-index of 0.75 [95 % CI 0.74-0.76]. Consistent risk factors included low social integration, limited physical activity, and low parental education in both cohorts, while additional factors post-reform included low self-esteem, poor self-rated health, and negative school experiences. CONCLUSION: Adolescents with co-occurring psychological distress and chronic pain face an elevated risk of early DP. Early identification and support are crucial, as risk factors extend beyond medical conditions. Findings also suggest that NAV policy changes may have influenced DP receipt rates among young adults. CI - Copyright (c) 2025 The Author(s). Published by Elsevier B.V. All rights reserved. FAU - Gorosito, Martin A AU - Gorosito MA AD - Centre for Intelligent Musculoskeletal Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway; Artificial Intelligence lab, Faculty of Technology, Art and Design, Oslo Metropolitan University, Oslo, Norway. Electronic address: martingo@oslomet.no. FAU - Berg, Bjornar AU - Berg B AD - Centre for Intelligent Musculoskeletal Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway; Department of Rehabilitation Science and Health Technology, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway. FAU - Yazidi, Anis AU - Yazidi A AD - Centre for Intelligent Musculoskeletal Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway; Artificial Intelligence lab, Faculty of Technology, Art and Design, Oslo Metropolitan University, Oslo, Norway; Department of Informatics, University of Oslo, Oslo, Norway; Department of Plastic and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway. FAU - Hermansen, Asmund AU - Hermansen A AD - Department of Social Work, Child Welfare and Social Policy, Faculty of Social Sciences, Oslo Metropolitan University, Oslo, Norway. FAU - Oiestad, Britt Elin AU - Oiestad BE AD - Centre for Intelligent Musculoskeletal Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway; Department of Rehabilitation Science and Health Technology, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway. FAU - Grotle, Margreth AU - Grotle M AD - Centre for Intelligent Musculoskeletal Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway; Department of Rehabilitation Science and Health Technology, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway. FAU - Richardsen, Kare Ronn AU - Richardsen KR AD - Centre for Intelligent Musculoskeletal Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway; Department of Rehabilitation Science and Health Technology, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway; Faculty of Health and Social Sciences, University of South-Eastern Norway, Oslo, Norway. FAU - Haugerud, Harek AU - Haugerud H AD - Centre for Intelligent Musculoskeletal Health, Faculty of Health Sciences, Oslo Metropolitan University, Oslo, Norway; Artificial Intelligence lab, Faculty of Technology, Art and Design, Oslo Metropolitan University, Oslo, Norway. LA - eng PT - Journal Article DEP - 20251204 PL - Ireland TA - Int J Med Inform JT - International journal of medical informatics JID - 9711057 SB - IM MH - Humans MH - *Chronic Pain/epidemiology/psychology MH - Female MH - Male MH - Norway/epidemiology MH - *Pensions/statistics & numerical data MH - Adolescent MH - *Persons with Disabilities/statistics & numerical data/psychology MH - Young Adult MH - *Psychological Distress MH - Risk Factors MH - *Stress, Psychological/epidemiology MH - Adult MH - Machine Learning OTO - NOTNLM OT - Chronic pain OT - Disability pension OT - Machine learning OT - Psychological distress OT - Survival analysis OT - Young adults COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/12 03:28 MHDA- 2026/01/03 00:30 CRDT- 2025/12/11 18:07 PHST- 2025/08/11 00:00 [received] PHST- 2025/10/30 00:00 [revised] PHST- 2025/12/02 00:00 [accepted] PHST- 2026/01/03 00:30 [medline] PHST- 2025/12/12 03:28 [pubmed] PHST- 2025/12/11 18:07 [entrez] AID - S1386-5056(25)00433-2 [pii] AID - 10.1016/j.ijmedinf.2025.106216 [doi] PST - ppublish SO - Int J Med Inform. 2026 Mar 1;207:106216. doi: 10.1016/j.ijmedinf.2025.106216. Epub 2025 Dec 4. PMID- 41379326 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20261009 IS - 1364-6753 (Electronic) IS - 1364-6745 (Linking) VI - 26 IP - 1 DP - 2025 Dec 11 TI - Gastrointestinal symptoms in neuronal ceroid lipofuscinoses (NCLs): an observational study on prevalence, timing of progression, and impact on quality of life. PG - 88 LID - 10.1007/s10048-025-00871-2 [doi] AB - Neuronal ceroid lipofuscinoses (NCLs) are rare, inherited lysosomal storage disorders (LSDs) of the brain and retina. Gastrointestinal (GI) manifestations are reported in clinical practice but remain largely underexplored. Lysosomal dysfunction affects both the central and the peripheral nervous systems, including the enteric nervous system (ENS) where accumulation of storage material and neuronal loss may directly contribute to GI dysmotility. These insights, combined with emerging gene therapies targeting both brain and ENS pathology, underscore the need for validated GI endpoints in NCL research. We present a cross-sectional study assessing prevalence, progression, and clinical impact of GI symptoms in an Italian NCL cohort. Using caregiver-reported data and standardized tools - including the PedsQL GI Symptoms Scales and the Hamburg rating Scale - we evaluated GI burden and its correlation with neurological severity. Over 60% of caregivers reported GI disturbances, with constipation as the most prevalent and earliest onset symptom. Nutritional issues, such as dysphagia, were common but tended to appear later. GI symptoms correlated well with decline in quality of life, especially for Trouble Swallowing (p(adj) <0.000001), Food and Drink Limits (p(adj) <0.000001), and Constipation (p(adj) = 0.026006). Problems with food and drink and swallowing problems correlated with the Hamburg rating Scale, while constipation did not, suggesting distinct underline mechanisms. Our findings support the importance of routine screening of GI symptoms in NCLs and their potential inclusion as extra-CNS endpoints in future therapeutic trials. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Della Vecchia, Stefania AU - Della Vecchia S AD - Department of Neurosciences, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Viale Pieraccini, 6, Florence, Italy. AD - Molecular Medicine Unit, IRCCS Fondazione Stella Maris, Pisa, 56128, Calambrone, Italy. FAU - Simonati, Alessandro AU - Simonati A AD - Department of Surgery, Dentistry, Pediatrics and Gynecology University of Verona, Verona, 37134, Italy. FAU - Manca, Maria Laura AU - Manca ML AD - Department of Clinical and Experimental Medicine and Department of Mathematics, University of Pisa and University Hospital of Pisa, Pisa, Italy. FAU - Pietrafusa, Nicola AU - Pietrafusa N AD - Neurology, Epilepsy and Movement Disorders Unit, IRCCS, Full Member of European Reference Network EpiCARE, Bambino Gesu Children's Hospital, Rome, Italy. FAU - Trivisano, Marina AU - Trivisano M AD - Neurology, Epilepsy and Movement Disorders Unit, IRCCS, Full Member of European Reference Network EpiCARE, Bambino Gesu Children's Hospital, Rome, Italy. FAU - Calabrese, Costanza AU - Calabrese C AD - Neurology, Epilepsy and Movement Disorders Unit, IRCCS, Full Member of European Reference Network EpiCARE, Bambino Gesu Children's Hospital, Rome, Italy. FAU - Specchio, Nicola AU - Specchio N AD - Neurology, Epilepsy and Movement Disorders Unit, IRCCS, Full Member of European Reference Network EpiCARE, Bambino Gesu Children's Hospital, Rome, Italy. AD - University Hospitals KU, Leuven, Belgium. FAU - Santorelli, Filippo Maria AU - Santorelli FM AD - Molecular Medicine Unit, IRCCS Fondazione Stella Maris, Pisa, 56128, Calambrone, Italy. filippo3364@gmail.com. CN - A-NCL-ETS LA - eng GR - Ricerca Corrente 2024/Ministero della Salute/ PT - Journal Article PT - Observational Study DEP - 20251211 PL - United States TA - Neurogenetics JT - Neurogenetics JID - 9709714 SB - IM MH - Humans MH - *Quality of Life MH - *Neuronal Ceroid-Lipofuscinoses/complications/epidemiology/physiopathology MH - Female MH - Male MH - Cross-Sectional Studies MH - Prevalence MH - Disease Progression MH - *Gastrointestinal Diseases/epidemiology/etiology/physiopathology MH - Child MH - Child, Preschool MH - Italy/epidemiology MH - Adolescent MH - Adult MH - Young Adult MH - Middle Aged MH - Infant OTO - NOTNLM OT - Neuronal ceroid lipofuscinosis OT - Paediatric neurodegenerative disorders OT - PedsQL gastrointestinal symptoms scales OT - Quality of life COIS- Declarations. Ethical approval: This study was approved by the Regione Toscana Pediatric Ethics Committee (CEPR code 130/2024; amendment code 198/2024) and was registered on ClinicalTrials.gov (NCT06844877). Patient consent statement: Written informed consent was obtained from all participants or their legal guardians. We confirm that we have read the Journal's position on issues involved in ethical publication and affirm that this work is consistent with those guidelines. Competing interests: The authors declare no competing interests. EDAT- 2025/12/11 13:04 MHDA- 2025/12/11 13:05 CRDT- 2025/12/11 11:13 PHST- 2025/09/18 00:00 [received] PHST- 2025/11/26 00:00 [accepted] PHST- 2025/12/11 13:05 [medline] PHST- 2025/12/11 13:04 [pubmed] PHST- 2025/12/11 11:13 [entrez] AID - 10.1007/s10048-025-00871-2 [pii] AID - 10.1007/s10048-025-00871-2 [doi] PST - epublish SO - Neurogenetics. 2025 Dec 11;26(1):88. doi: 10.1007/s10048-025-00871-2. PMID- 41379304 OWN - NLM STAT- MEDLINE DCOM- 20260406 LR - 20261010 IS - 1720-8386 (Electronic) IS - 0391-4097 (Linking) VI - 49 IP - 4 DP - 2026 Apr TI - Anti-Mullerian hormone in anorexia nervosa: a biomarker of nutritional status and reproductive phenotype. PG - 867-877 LID - 10.1007/s40618-025-02776-1 [doi] AB - PURPOSE: To investigate Anti-Mullerian Hormone (AMH) levels in women with anorexia nervosa (AN) compared to individuals with constitutional thinness (CT) and healthy controls, and to evaluate the association between AMH, body mass index (BMI), and weight recovery. METHODS: This monocentric cross-sectional study included 191 women with AN, 41 with CT, and 55 controls. A subgroup of 42 patients with AN was reassessed after weight recovery. Hormonal, metabolic, and psychological parameters were analyzed. AMH was measured using a validated electrochemiluminescence immunoassay. Comparisons and correlations were performed using nonparametric tests and Pearson coefficients. RESULTS: Mean AMH plasma level was higher in patients with AN (30.5 +/- 1.6 pmol/l) than in controls (23.3 +/- 2.5 pmol/l, p = 0.0252) and CT (21.4 +/- 2.7 pmol/l, p = 0.0088). AMH was positively correlated with BMI, leptin, FSH, and LH in the AN group, and inversely associated with disease duration. AMH was the lowest in extreme undernutrition state (BMI /= 40 kg/m(2)) were excluded. Nutrition scores (HALP, PNI, NRI, CONUT) and systemic immune-inflammation indices (SII, NLR, PLR) were calculated from laboratory data. For the comparisons of SII, PLR, NLR, PNI, HALP, NRI, and CONUT values between groups, age was adjusted for, and an ANCOVA test was performed. Results: Among the systemic immune-inflammation indices, SII and NLR were significantly higher in both the overweight and obesity groups. The CONUT score, a negative indicator of nutritional status, demonstrated positive correlations with SII, NLR, and PLR in the overweight group, and with PLR in the obesity group. Although PNI showed significant inverse correlations with SII, PLR, and NLR in both groups, the mean PNI values remained above 50, indicating overall normal nutritional status in the study population. HALP was inversely correlated with SII, PLR, and NLR in both groups. Conclusions: The HALP score appears to be the most reliable marker, as it reflects the inverse relationship between nutritional status and systemic immune-inflammation indices. FAU - Uzun, Hafize AU - Uzun H AUID- ORCID: 0000-0002-1347-8498 AD - Department of Medical Biochemistry, Faculty of Medicine, Istanbul Atlas University, 34403 Istanbul, Turkey. FAU - Fenercioglu, Aysen Kutan AU - Fenercioglu AK AUID- ORCID: 0000-0003-2965-6102 AD - Department of Family Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, 34098 Istanbul, Turkey. FAU - Senyigit, Abdulhalim AU - Senyigit A AD - Department of Internal Medicine, Faculty of Medicine, Istanbul Atlas University, 34403 Istanbul, Turkey. FAU - Can, Gunay AU - Can G AD - Department of Public Health, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, 34098 Istanbul, Turkey. LA - eng PT - Journal Article DEP - 20251203 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Nutritional Status/immunology MH - Adult MH - *Body Mass Index MH - *Inflammation/immunology/blood MH - Female MH - Male MH - Middle Aged MH - Retrospective Studies MH - Young Adult MH - Adolescent MH - Biomarkers/blood MH - Nutrition Assessment MH - Neutrophils MH - Obesity/immunology/blood MH - Lymphocytes MH - Overweight/immunology/blood PMC - PMC12694329 OTO - NOTNLM OT - BMI OT - CONUT OT - HALP score OT - NLR OT - NRI OT - PLR OT - PNI OT - SII COIS- The authors declare no conflicts of interest. EDAT- 2025/12/11 07:43 MHDA- 2025/12/11 07:44 PMCR- 2025/12/03 CRDT- 2025/12/11 01:04 PHST- 2025/11/04 00:00 [received] PHST- 2025/11/30 00:00 [revised] PHST- 2025/12/02 00:00 [accepted] PHST- 2025/12/11 07:44 [medline] PHST- 2025/12/11 07:43 [pubmed] PHST- 2025/12/11 01:04 [entrez] PHST- 2025/12/03 00:00 [pmc-release] AID - nu17233799 [pii] AID - nutrients-17-03799 [pii] AID - 10.3390/nu17233799 [doi] PST - epublish SO - Nutrients. 2025 Dec 3;17(23):3799. doi: 10.3390/nu17233799. PMID- 41374086 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20251214 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 23 DP - 2025 Dec 3 TI - Birth Satisfaction and Breastfeeding Attitudes Among Mothers Aged 35 and Older. LID - 10.3390/nu17233796 [doi] LID - 3796 AB - Background/Objectives: Delayed motherhood is becoming increasingly common, yet limited evidence exists on birth satisfaction and breastfeeding attitudes among women aged >/=35. In this study, the hypothesis was tested whether higher birth satisfaction and stronger social support are associated with more positive breastfeeding attitudes and if previous childbirth experience moderates these relationships. Methods: A cross-sectional online survey was conducted among 148 Polish women up to 12 months postpartum. Participants were recruited via social media and parenting-related online communities; the survey was disseminated across multiple online channels to enhance representativeness and reduce potential sampling bias. Eligibility included age >/=35 at childbirth and informed consent. The sample size was considered adequate based on recommendations for regression models with the number of included predictors. Validated tools were used (MSPSS, IIFAS-Pol, BSS-R PL). Assumptions for Pearson's correlation coefficients and linear regression (normality, homoscedasticity, absence of multicollinearity) were checked prior to analyses. The analysis was performed using IBM SPSS Statistics 29 (IBM Corp., Armonk, New York, NY, USA). Results: Women aged >/=35 reported high birth satisfaction and generally positive breastfeeding attitudes. Among multiparous women, birth satisfaction was moderately positively associated with breastfeeding attitudes (BSS-R PL; r = 0.396, p < 0.01), and perceived social support showed a small but significant association (MSPSS; r = 0.249, p < 0.05). Hierarchical regression analyses indicated that, in women over 35 with a subsequent child, psychosocial variables significantly predicted breastfeeding attitudes, whereas the control model-including education, socioeconomic status, and delivery mode-was not significant. Adding birth satisfaction and perceived social support improved model fit (R(2) = 0.194), with birth satisfaction emerging as the only significant predictor (beta = 0.31). The corresponding effect size (f(2) = 0.143) indicated a near-medium effect. In contrast, neither the control nor the extended model was significant among primiparous women, suggesting no meaningful associations in this group. Conclusions: Higher birth satisfaction and perceived social support may promote more favorable breastfeeding attitudes in women becoming mothers at >/=35, with stronger effects among multiparous mothers. These findings highlight the need for individualized prenatal education, enhanced psychosocial support, partner involvement and efforts to improve childbirth experiences. Interventions tailored to women entering motherhood at an advanced maternal age are warranted. FAU - Sobala, Amelia Julia AU - Sobala AJ AD - Department of Obstetric and Gynecological Nursing, Institute of Nursing and Midwifery, Gdansk Medical University, Sklodowskiej-Curie 3 A, 80-210 Gdansk, Poland. FAU - Szablewska, Anna Weronika AU - Szablewska AW AUID- ORCID: 0000-0001-8565-027X AD - Department of Obstetric and Gynecological Nursing, Institute of Nursing and Midwifery, Gdansk Medical University, Sklodowskiej-Curie 3 A, 80-210 Gdansk, Poland. LA - eng PT - Journal Article DEP - 20251203 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Female MH - *Breast Feeding/psychology MH - Adult MH - Cross-Sectional Studies MH - Social Support MH - *Mothers/psychology MH - *Personal Satisfaction MH - *Parturition/psychology MH - Surveys and Questionnaires MH - Poland MH - Pregnancy PMC - PMC12694116 OTO - NOTNLM OT - attitudes towards breastfeeding OT - birth satisfaction OT - late motherhood OT - perinatal care OT - psychosocial factors OT - social support COIS- The authors declare no conflicts of interest. EDAT- 2025/12/11 07:43 MHDA- 2025/12/11 07:44 PMCR- 2025/12/03 CRDT- 2025/12/11 01:04 PHST- 2025/10/25 00:00 [received] PHST- 2025/11/28 00:00 [revised] PHST- 2025/12/02 00:00 [accepted] PHST- 2025/12/11 07:44 [medline] PHST- 2025/12/11 07:43 [pubmed] PHST- 2025/12/11 01:04 [entrez] PHST- 2025/12/03 00:00 [pmc-release] AID - nu17233796 [pii] AID - nutrients-17-03796 [pii] AID - 10.3390/nu17233796 [doi] PST - epublish SO - Nutrients. 2025 Dec 3;17(23):3796. doi: 10.3390/nu17233796. PMID- 41374069 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20251214 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 23 DP - 2025 Dec 2 TI - Do Physical Activity and Diet Independently Account for Variation in Body Fat in Children and Adolescents? A Systematic Review Unpacking the Roles of Exercise and Diet in Childhood Obesity. LID - 10.3390/nu17233779 [doi] LID - 3779 AB - Background/Objectives: Physical activity (PA) and energy intake (EI) are central targets of community initiatives to reduce the prevalence of childhood obesity. The general effects of PA and EI in influencing energy balance and body composition are clear. However, the independent impacts of PA and EI on the adiposity of children growing up amidst westernized lifestyles are inconclusive, as few studies have employed sufficiently robust methodology to provide solid independent associative data. Methods: We carried out a systematic review of the research addressing the independent associations of adiposity with each of PA and EI in free-living town or city-dwelling children and adolescents. Acceptable publications included objective measures of fat mass and PA, best standard practice EI assessments, and appropriate statistical modeling. Results: Of approximately 700 publications explored, only four satisfied all the pre-set methodological standards. All four studies involved predominantly White participants from westernized cities and had the same outcomes. Adiposity was strongly independently and negatively related to PA, but there was no evidence of any independent relationship between adiposity and EI. Potential misreporting was considered, especially under-reporting by participants with greater adiposity, butpost-hoc assessments were unable to find any evidence that this influenced the outcomes. Conclusions: In general, children with higher adiposity consumed no more food and beverage energy than their leaner counterparts, but they were less active. However, despite some support for the validity of the commonly used and validated EI assessments, their subjective nature raises the possibility that inaccuracy masked relationships. Additional well-designed research is needed, and notwithstanding the vital role that sound nutrition plays in the healthy development of our youth, the consistency of outcomes of the well-executed studies in this review suggests that campaigns targeting youth obesity would benefit from strategies focusing strongly on increasing PA. FAU - Telford, Richard D AU - Telford RD AUID- ORCID: 0000-0003-4485-9362 AD - Research Institute for Sport and Exercise, University of Canberra, Bruce, ACT 2617, Australia. AD - Health Research Institute, University of Canberra, Bruce, ACT 2617, Australia. FAU - Jayasinghe, Sisitha AU - Jayasinghe S AUID- ORCID: 0000-0001-8805-385X AD - Independent Researcher, Newcastle NE1 1EN, UK. FAU - Byrne, Nuala M AU - Byrne NM AUID- ORCID: 0000-0001-5310-6640 AD - School of Health Sciences, UTAS Health, University of Tasmania, Launceston, TAS 7250, Australia. FAU - Telford, Rohan M AU - Telford RM AUID- ORCID: 0000-0002-1723-2559 AD - National Centre for Epidemiology and Population Health, Australian National University, Canberra, ACT 2601, Australia. FAU - Hills, Andrew P AU - Hills AP AUID- ORCID: 0000-0002-6849-6116 AD - School of Health Sciences, UTAS Health, University of Tasmania, Launceston, TAS 7250, Australia. LA - eng PT - Journal Article PT - Systematic Review DEP - 20251202 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Adolescent MH - Child MH - Female MH - Humans MH - Male MH - *Adipose Tissue MH - *Adiposity MH - *Diet MH - Energy Intake MH - *Exercise MH - *Pediatric Obesity/prevention & control/epidemiology/physiopathology PMC - PMC12693829 OTO - NOTNLM OT - BMI OT - adolescents OT - body composition OT - childhood obesity OT - diet OT - dietary surveys OT - energy expenditure OT - energy intake OT - percent body fat OT - physical activity OT - sedentarism COIS- The authors declare no conflict of interest. EDAT- 2025/12/11 07:44 MHDA- 2025/12/11 07:45 PMCR- 2025/12/02 CRDT- 2025/12/11 01:04 PHST- 2025/10/31 00:00 [received] PHST- 2025/11/24 00:00 [revised] PHST- 2025/11/30 00:00 [accepted] PHST- 2025/12/11 07:45 [medline] PHST- 2025/12/11 07:44 [pubmed] PHST- 2025/12/11 01:04 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - nu17233779 [pii] AID - nutrients-17-03779 [pii] AID - 10.3390/nu17233779 [doi] PST - epublish SO - Nutrients. 2025 Dec 2;17(23):3779. doi: 10.3390/nu17233779. PMID- 41374062 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20251214 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 23 DP - 2025 Nov 30 TI - Effects of Lifestyle, Diet, and Body Composition on Free Testosterone and Cortisol Levels in Young Men. LID - 10.3390/nu17233772 [doi] LID - 3772 AB - Background/Objectives: Testosterone and cortisol are key regulators of metabolic, psychological, and physiological responses to environmental and lifestyle factors. This study aimed to analyze the relationship between free testosterone and cortisol concentrations and dietary patterns, stress levels, sleep quality, physical activity, and body composition in healthy young men (aged 18-35 years). Methods: This study included 40 volunteers who met our inclusion criteria. They underwent anthropometric measurements, body composition analysis, and biochemical determination of serum free testosterone and cortisol concentrations. Additionally, participants completed a set of validated questionnaires: a questionnaire regarding the frequency of consumption of specific foods and stimulants, a 3-day food diary, the PSS-10, the Holmes and Rahe Scale, the PSQI, and the Baecke Physical Activity Questionnaire. Results: Free testosterone concentration in blood was negatively correlated with body fat content and positively correlated with the percentage of energy, protein, fat, sodium, and folic acid requirements. Morning blood cortisol levels negatively correlated with body weight and height. Higher intakes of cholesterol, folic acid, and vitamin A resulted in statistically significant reductions in cortisol levels. A significant correlation was identified between poor sleep quality and low cortisol levels, particularly among men aged < 26 years. A positive correlation was also found between leisure-time physical activity and testosterone levels, particularly in the older group. Furthermore, a higher body weight and greater muscle mass were correlated with lower cortisol levels. Conclusions: These results provide a starting point for further research on neuroendocrine mechanisms in active individuals exposed to environmental stress. FAU - Mazurkiewicz, Dominika AU - Mazurkiewicz D AUID- ORCID: 0000-0002-3225-1053 AD - Department of Human Nutrition, Faculty of Biotechnology and Food Sciences, Wroclaw University of Environmental and Life Sciences, Chelmonskiego 37, 51-630 Wroclaw, Poland. FAU - Gajda, Robert AU - Gajda R AUID- ORCID: 0000-0001-7957-918X AD - Department of Human Nutrition, Faculty of Biotechnology and Food Sciences, Wroclaw University of Environmental and Life Sciences, Chelmonskiego 37, 51-630 Wroclaw, Poland. FAU - Ambrozik-Haba, Jagoda AU - Ambrozik-Haba J AUID- ORCID: 0000-0003-4519-9052 AD - Department of Human Nutrition, Faculty of Biotechnology and Food Sciences, Wroclaw University of Environmental and Life Sciences, Chelmonskiego 37, 51-630 Wroclaw, Poland. FAU - Bozek, Wiktoria AU - Bozek W AD - Department of Human Nutrition, Faculty of Biotechnology and Food Sciences, Wroclaw University of Environmental and Life Sciences, Chelmonskiego 37, 51-630 Wroclaw, Poland. FAU - Ceremuga, Maja AU - Ceremuga M AD - Department of Human Nutrition, Faculty of Biotechnology and Food Sciences, Wroclaw University of Environmental and Life Sciences, Chelmonskiego 37, 51-630 Wroclaw, Poland. FAU - Serek, Pawel AU - Serek P AUID- ORCID: 0000-0002-4685-4373 AD - Department of Human Nutrition, Faculty of Biotechnology and Food Sciences, Wroclaw University of Environmental and Life Sciences, Chelmonskiego 37, 51-630 Wroclaw, Poland. LA - eng GR - The APC is co-financed by Wroclaw University of Environmental and Life Sciences/Wroclaw University of Environmental and Life Sciences/ GR - The APC is co-financed by Wroclaw University of Environmental and Life Sciences/The APC is co-financed by Wroclaw University of Environmental and Life Sciences/ PT - Journal Article DEP - 20251130 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - WI4X0X7BPJ (Hydrocortisone) RN - 3XMK78S47O (Testosterone) SB - IM MH - Humans MH - Male MH - *Hydrocortisone/blood MH - *Testosterone/blood MH - Adult MH - *Body Composition/physiology MH - Young Adult MH - *Life Style MH - Adolescent MH - *Diet MH - Exercise/physiology MH - Sleep Quality MH - Surveys and Questionnaires PMC - PMC12694065 OTO - NOTNLM OT - alcohol OT - cortisol OT - lifestyle OT - nutrition OT - sleep OT - smoking OT - stress OT - testosterone COIS- The authors declare no conflicts of interest. EDAT- 2025/12/11 07:43 MHDA- 2025/12/11 07:44 PMCR- 2025/11/30 CRDT- 2025/12/11 01:04 PHST- 2025/10/29 00:00 [received] PHST- 2025/11/27 00:00 [revised] PHST- 2025/11/28 00:00 [accepted] PHST- 2025/12/11 07:44 [medline] PHST- 2025/12/11 07:43 [pubmed] PHST- 2025/12/11 01:04 [entrez] PHST- 2025/11/30 00:00 [pmc-release] AID - nu17233772 [pii] AID - nutrients-17-03772 [pii] AID - 10.3390/nu17233772 [doi] PST - epublish SO - Nutrients. 2025 Nov 30;17(23):3772. doi: 10.3390/nu17233772. PMID- 41374060 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20251214 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 23 DP - 2025 Nov 30 TI - The Real Danger for Milk Protein Allergy: Developing a Scale for Family Doctors on Introducing Diet Diversity to Infants with Cow's Milk Protein Allergy. LID - 10.3390/nu17233770 [doi] LID - 3770 AB - Background: Cow's milk protein allergy (CMPA) is one of the most common food allergies in infants, with a reported prevalence between 0.54% and 4.9%. In Europe, 1% of children are affected by CMPA in the first 2 years of life. Overdiagnosis leads to unnecessary dietary restrictions, with additional costs, while neglecting the diagnosis of CMPA has long-term repercussions on growth and development or, in the case of an acute reaction, may involve a life-threatening risk. The aim of this study is to develop a scale for family doctors to assess their practical knowledge of allergic pathology in newborns. Materials and Methods: To develop the scale, seven family doctors, each with over 10 years of practical experience, reached a consensus on the 20 items. The items were based on the guidelines of the European Academy of Allergology and Clinical Immunology on the prevention of food allergies in infants and young children. To verify the validity and internal structure of the scale, we conducted a pilot study on family doctors (N = 45), with a predominantly pediatric population, from one of the four university centers in Romania (Iasi region). The results showed a good internal structure of the items in our scale. Content validity showed an I-CVI = 0.79 and an S-CVI = 0.91, which means that the scale can be considered excellent in terms of content. Discussion: The results of our study suggest that the new scale designed to assess the practical knowledge of family physicians in the field of allergic pathology in newborns, particularly with regard to cow's milk protein allergy (CMPA), has solid psychometric properties. The excellent content validity, indicated by an item content validity index (I-CVI) of 0.79 and a scale content validity index (S-CVI) of 0.91, reflects strong agreement among experts on the relevance and comprehensiveness of the items included. Conclusions: The designed scale demonstrates excellent content validity and good internal structure, indicating that it is a reliable tool for assessing the practical knowledge of family physicians in the field of allergic pathology in newborns. This scale can support the improvement of the identification and management of cow's milk protein allergy in primary health care. FAU - Stafie, Celina Silvia AU - Stafie CS AUID- ORCID: 0000-0002-9865-4349 AD - Preventive Medicine and Interdisciplinarity Department, University of Medicine "Grigore T. Popa" Iasi, 700115 Iasi, Romania. LA - eng PT - Journal Article DEP - 20251130 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Milk Proteins) SB - IM MH - Humans MH - *Milk Hypersensitivity/diagnosis/prevention & control/diet therapy MH - Infant MH - *Milk Proteins/immunology/adverse effects MH - Infant, Newborn MH - Female MH - *Physicians, Family MH - Pilot Projects MH - Romania MH - *Diet MH - Male MH - Animals MH - Surveys and Questionnaires MH - Health Knowledge, Attitudes, Practice MH - Reproducibility of Results PMC - PMC12693831 OTO - NOTNLM OT - CMPA OT - breastfeeding OT - cow's milk protein allergy OT - dietary diversity OT - food allergy COIS- The author declares no conflict of interest. EDAT- 2025/12/11 07:42 MHDA- 2025/12/11 07:43 PMCR- 2025/11/30 CRDT- 2025/12/11 01:04 PHST- 2025/10/02 00:00 [received] PHST- 2025/11/22 00:00 [revised] PHST- 2025/11/29 00:00 [accepted] PHST- 2025/12/11 07:43 [medline] PHST- 2025/12/11 07:42 [pubmed] PHST- 2025/12/11 01:04 [entrez] PHST- 2025/11/30 00:00 [pmc-release] AID - nu17233770 [pii] AID - nutrients-17-03770 [pii] AID - 10.3390/nu17233770 [doi] PST - epublish SO - Nutrients. 2025 Nov 30;17(23):3770. doi: 10.3390/nu17233770. PMID- 41374041 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20251214 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 23 DP - 2025 Nov 28 TI - Validity and Reliability of a Food Frequency Questionnaire (NFFQ-Kids) to Assess Food Consumption Based on the Nova Classification in Southern Italian Children and Adolescents. LID - 10.3390/nu17233751 [doi] LID - 3751 AB - Background/Objectives: There is a lack of food frequency questionnaires (FFQs) specifically designed to assess food consumption based on processing levels in younger populations. This study evaluates the validity and the reliability of a 107-item FFQ (NFFQ-Kids) in estimating the intake (g/day) and the weight and energy ratios of Nova groups in Italian children and adolescents aged 2-18 years. Methods: The NFFQ-Kids was administered twice (T0 and T1), with a four-week interval. A total of 73 participants completed the questionnaire at T0, and 53 completed it at T1. Participants were selected from the ICARO Study (December 2023-April 2024), a web-based cohort study in Southern Italy. Questionnaire validity was assessed by comparison with a 3-day food record (two weekdays and one weekend day) collected between the two NFFQ-Kids administrations. Test-retest reliability was evaluated to assess the consistency of the questionnaire over time. Results: A moderate correlation was found between the NFFQ-Kids and the 3-day food record for the energy ratio of ultra-processed foods (UPFs) (r = 0.48; p < 0.001; ICC = 0.46; 95% CI 0.29-0.64) and the weight ratio for both unprocessed or minimally processed foods (r = 0.49; p < 0.001; ICC = 0.50; 95%CI 0.33-0.66) and ultra-processed foods (UPFs) (r = 0.58; p < 0.001; ICC = 0.58; 95%CI 0.42-0.72). Overall, the NFFQ-Kids showed good test-retest reliability across all Nova group intakes, total food, and relative energy and weight ratios of UPFs (r = 0.71, ICC = 0.67; and r = 0.79, ICC = 0.67, respectively), indicating stable measurements over time. Conclusions: The NFFQ-Kids demonstrated acceptable validity and good reliability, proving useful for assessing food intake by processing level in Italian youth. FAU - Paladino, Nadia AU - Paladino N AUID- ORCID: 0000-0002-2463-5321 AD - Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy. FAU - Di Costanzo, Giuseppe AU - Di Costanzo G AUID- ORCID: 0009-0003-3550-7987 AD - Research Unit of Epidemiology and Prevention, Istituto Neurologico Mediterraneo IRCCS NEUROMED, 86077 Pozzilli, Italy. FAU - Ruggiero, Emilia AU - Ruggiero E AUID- ORCID: 0000-0002-7109-1128 AD - Research Unit of Epidemiology and Prevention, Istituto Neurologico Mediterraneo IRCCS NEUROMED, 86077 Pozzilli, Italy. FAU - Di Castelnuovo, Augusto AU - Di Castelnuovo A AD - Research Unit of Epidemiology and Prevention, Istituto Neurologico Mediterraneo IRCCS NEUROMED, 86077 Pozzilli, Italy. FAU - Dello Russo, Marika AU - Dello Russo M AUID- ORCID: 0000-0002-7630-265X AD - Institute of Food Sciences, Consiglio Nazionale delle Ricerche, 83100 Avellino, Italy. FAU - Formisano, Annarita AU - Formisano A AUID- ORCID: 0000-0001-7328-3716 AD - Institute of Food Sciences, Consiglio Nazionale delle Ricerche, 83100 Avellino, Italy. FAU - Lauria, Fabio AU - Lauria F AUID- ORCID: 0000-0002-1663-1582 AD - Institute of Food Sciences, Consiglio Nazionale delle Ricerche, 83100 Avellino, Italy. FAU - Currenti, Walter AU - Currenti W AD - Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy. FAU - Galvano, Fabio AU - Galvano F AUID- ORCID: 0000-0003-0644-0755 AD - Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy. AD - College of Health Science, Princess Nourah Bint Abdulrahman University, Riyad 11564, Saudi Arabia. FAU - Grosso, Giuseppe AU - Grosso G AUID- ORCID: 0000-0003-3930-5285 AD - Department of Biomedical and Biotechnological Sciences, University of Catania, 95124 Catania, Italy. AD - Center for Human Nutrition and Mediterranean Foods (NUTREA), University of Catania, 95124 Catania, Italy. FAU - Iacoviello, Licia AU - Iacoviello L AUID- ORCID: 0000-0003-0514-5885 AD - Research Unit of Epidemiology and Prevention, Istituto Neurologico Mediterraneo IRCCS NEUROMED, 86077 Pozzilli, Italy. AD - Department of Medicine and Surgery, LUM University, 70010 Casamassima, Italy. FAU - Bonaccio, Marialaura AU - Bonaccio M AUID- ORCID: 0000-0002-8082-6552 AD - Research Unit of Epidemiology and Prevention, Istituto Neurologico Mediterraneo IRCCS NEUROMED, 86077 Pozzilli, Italy. LA - eng GR - PE0000003/Ministero dell'universita e della ricerca/ PT - Journal Article PT - Validation Study DEP - 20251128 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Child MH - Italy MH - Adolescent MH - Reproducibility of Results MH - Male MH - Female MH - Child, Preschool MH - Surveys and Questionnaires/standards MH - *Diet Surveys/methods MH - Diet Records MH - *Feeding Behavior MH - Energy Intake MH - *Diet/statistics & numerical data MH - Fast Foods MH - Nutrition Assessment MH - *Eating PMC - PMC12694190 OTO - NOTNLM OT - Nova classification OT - children/adolescents OT - food frequency questionnaire OT - reliability OT - ultra-processed foods OT - validity COIS- The authors declare no conflicts of interest. EDAT- 2025/12/11 07:43 MHDA- 2025/12/11 07:44 PMCR- 2025/11/28 CRDT- 2025/12/11 01:04 PHST- 2025/10/27 00:00 [received] PHST- 2025/11/21 00:00 [revised] PHST- 2025/11/26 00:00 [accepted] PHST- 2025/12/11 07:44 [medline] PHST- 2025/12/11 07:43 [pubmed] PHST- 2025/12/11 01:04 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - nu17233751 [pii] AID - nutrients-17-03751 [pii] AID - 10.3390/nu17233751 [doi] PST - epublish SO - Nutrients. 2025 Nov 28;17(23):3751. doi: 10.3390/nu17233751. PMID- 41374038 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20251214 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 23 DP - 2025 Nov 28 TI - Nutrition Literacy Among University Students in Beijing: Status, Determinants, and Implications. LID - 10.3390/nu17233748 [doi] LID - 3748 AB - BACKGROUND: Nutrition literacy (NL) plays a crucial role in shaping long-term health behaviors among college students, particularly during the transformative final phase of their school education. This study investigated the level of NL among college students in Beijing and examined its association with these behaviors. METHODS: A cross-sectional online survey was conducted among 765 students from 12 universities in Beijing. The questionnaire comprised three sections: demographic characteristics, lifestyle factors, and a nutrition literacy scale (Cronbach's alpha = 0.893; chi(2)/DF = 4.750; RMSEA = 0.048; GFI = 0.891; AGFI = 0.876). The NL scale was divided into two domains: cognition and skills. Descriptive statistics were used to summarize NL scores and their distributions across dimensions and subgroups. Group differences for categorical variables were examined using chi-square or Fisher's exact tests. Logistic regression analyses was employed to identify factors associated with NL. Mediation effects were tested using the Baron and Kenny approach. RESULTS: The mean NL score was 67.74 +/- 9.07, with only 7.6% of participants achieving an excellent NL level. Several lifestyle factors were significantly associated with excellent NL. Students with monthly living expenses of 2000-3000 CNY (OR = 2.35, p = 0.019) and >3000 CNY (OR = 3.22, p = 0.023) had higher odds of excellent NL compared to those spending <2000 CNY. Occasional exercise (OR = 2.36, p = 0.026) and daily breakfast consumption (OR = 2.76, p = 0.027) were also positively associated with excellent NL. In contrast, frequent midnight snacking significantly reduced the likelihood of excellent NL (OR = 0.20, p = 0.031). Better self-rated health status was strongly correlated with higher NL (OR = 2.82, p = 0.012). Moreover, NL mediated the relationship between lifestyle factors and healthy eating behaviors, underscoring a gap between nutritional knowledge and practical food skills. CONCLUSIONS: Current findings indicated suboptimal nutrition literacy among college students in Beijing, particularly in food selection skills. Excellent NL rates were associated with demographic and lifestyle factors, with NL serving as a mediator between lifestyle and health-related behaviors. These results emphasize the need for targeted nutrition education programs to enhance both knowledge and practical skills among university students. FAU - Li, Wenpeng AU - Li W AUID- ORCID: 0009-0001-0114-903X AD - The School of Public Health, Peking University, Beijing 100191, China. FAU - Yang, Bohao AU - Yang B AUID- ORCID: 0009-0003-2578-8359 AD - The School of Public Health, Peking University, Beijing 100191, China. FAU - Zhai, Jianrui AU - Zhai J AD - The School of Public Health, Peking University, Beijing 100191, China. FAU - Li, Jiahui AU - Li J AD - The School of Public Health, Peking University, Beijing 100191, China. FAU - Tian, Lunrongyi AU - Tian L AD - The School of Public Health, Peking University, Beijing 100191, China. FAU - Xu, Meihong AU - Xu M AUID- ORCID: 0000-0001-7201-6982 AD - The School of Public Health, Peking University, Beijing 100191, China. AD - Department of Nutrition and Food Hygiene, School of Public Health, Beijing Key Laboratory of Toxicological Research and Risk, Assessment for Food Safety, Peking University, Beijing 100191, China. AD - Institute of Medical Technology, Peking University Health Science Center, Beijing 100019, China. LA - eng PT - Journal Article DEP - 20251128 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 SB - IM MH - Humans MH - Male MH - Female MH - *Students/psychology/statistics & numerical data MH - Universities MH - Beijing MH - Cross-Sectional Studies MH - Young Adult MH - *Health Literacy/statistics & numerical data MH - Adult MH - Surveys and Questionnaires MH - Life Style MH - *Nutritional Status MH - Health Behavior MH - Adolescent MH - Health Knowledge, Attitudes, Practice PMC - PMC12694335 OTO - NOTNLM OT - health behaviors OT - influencing factors OT - nutrition literacy OT - university students COIS- The authors declare that they have no competing interests. EDAT- 2025/12/11 07:44 MHDA- 2025/12/11 07:45 PMCR- 2025/11/28 CRDT- 2025/12/11 01:04 PHST- 2025/10/25 00:00 [received] PHST- 2025/11/25 00:00 [revised] PHST- 2025/11/26 00:00 [accepted] PHST- 2025/12/11 07:45 [medline] PHST- 2025/12/11 07:44 [pubmed] PHST- 2025/12/11 01:04 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - nu17233748 [pii] AID - nutrients-17-03748 [pii] AID - 10.3390/nu17233748 [doi] PST - epublish SO - Nutrients. 2025 Nov 28;17(23):3748. doi: 10.3390/nu17233748. PMID- 41374006 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20251214 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 23 DP - 2025 Nov 27 TI - Low Skeletal Muscle Mass Identifies Very High Metabolic Risk in Slovak Children with Obesity: A Body Composition-Based Approach to Risk Stratification. LID - 10.3390/nu17233715 [doi] LID - 3715 AB - Background: Childhood obesity demonstrates substantial metabolic heterogeneity. We determined insulin resistance prevalence in Slovak children with obesity using multiple validated markers and identified high-risk phenotypes. Methods: Cross-sectional study of 54 obese children (BMI 29.5 +/- 4.7 kg/m(2)) and 33 controls (BMI 20.6 +/- 1.9 kg/m(2)). All underwent bioelectrical impedance analysis and fasting metabolic profiling, including HOMA-IR and triglyceride-to-HDL cholesterol (TG/HDL-C) ratio. Insulin resistance was defined as HOMA-IR > 3.42 (obese) or >1.68 (controls), and TG/HDL-C > 0.99 mmol/L. Age-matched sensitivity analysis was performed on 28 pairs. Results: Among obese children, 44.4% demonstrated HOMA-IR-defined insulin resistance versus 45.5% of controls using respective cut-offs, with significantly higher mean HOMA-IR (3.66 +/- 2.09 vs. 2.53 +/- 2.59, p = 0.034). Age-matched analysis (n = 28 pairs, mean age difference 0.22 years) confirmed these findings with HOMA-IR 3.46 +/- 2.18 vs. 2.27 +/- 2.22 (p = 0.0271). The TG/HDL-C ratio identified insulin resistance in 38.9% of obese versus 12.1% of controls. Critically, 22.2% of obese children showed concordant elevation of both markers (vs. 6.1% controls; OR 4.43); in age-matched analysis, this difference was even more pronounced (17.9% vs. 3.6%). Low skeletal muscle mass (<25th percentile for age and sex) with high body fat (>40%) characterized 22.6% of obese children, demonstrating 91.7% insulin resistance prevalence versus 31.0% without low muscle mass (p < 0.001), with HOMA-IR 1.9 points higher (95% CI: 0.31-2.73). Remarkably, 50% of children with low muscle mass showed concordant elevation of both metabolic markers versus 14.3% without (OR 6.0). Conclusions: Low skeletal muscle mass in obese Slovak children represents a very-high-risk phenotype with 91.7% insulin resistance prevalence and 6-fold increased odds of severe metabolic dysfunction. Age-matched analysis confirmed that metabolic differences are independent of age effects. Body composition-based risk stratification enables personalized interventions targeting the highest-risk children. FAU - Banovcinova, Alzbeta AU - Banovcinova A AUID- ORCID: 0000-0002-5456-5459 AD - Department of Paediatrics and Adolescent Medicine, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, 04011 Kosice, Slovakia. FAU - Schusterova, Ingrid AU - Schusterova I AUID- ORCID: 0000-0002-0410-6967 AD - Department of Imaging Techniques, East Slovak Institute of Cardiovascular Diseases, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Ondavska 8, 04001 Kosice, Slovakia. FAU - Toth, Stefan AU - Toth S AUID- ORCID: 0000-0002-9789-3305 AD - Department of Gerontology and Geriatrics, University Hospital of St. Michael, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Murgasova 1, 04086 Kosice, Slovakia. FAU - Poruban, Tibor AU - Poruban T AUID- ORCID: 0000-0001-6946-3765 AD - 1st Department of Cardiology, East Slovak Institute of Cardiovascular Diseases, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Ondavska 8, 04011 Kosice, Slovakia. FAU - Pella, Dominik AU - Pella D AD - 1st Department of Cardiology, East Slovak Institute of Cardiovascular Diseases, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Ondavska 8, 04011 Kosice, Slovakia. FAU - Dvoroznakova, Mariana AU - Dvoroznakova M AD - 2nd Department of Cardiology, East Slovak Institute of Cardiovascular Diseases, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Ondavska 8, 04011 Kosice, Slovakia. FAU - Fulop, Pavol AU - Fulop P AUID- ORCID: 0000-0002-8811-025X AD - 2nd Department of Cardiology, East Slovak Institute of Cardiovascular Diseases, Faculty of Medicine, Pavol Jozef Safarik University in Kosice, Ondavska 8, 04011 Kosice, Slovakia. LA - eng GR - 1/0700/23/vega/ PT - Journal Article DEP - 20251127 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Triglycerides) RN - 0 (Cholesterol, HDL) SB - IM MH - Humans MH - Slovakia/epidemiology MH - Male MH - Female MH - Child MH - *Insulin Resistance MH - Cross-Sectional Studies MH - *Pediatric Obesity/epidemiology/physiopathology/complications MH - *Body Composition MH - *Muscle, Skeletal/physiopathology MH - Risk Assessment MH - Electric Impedance MH - Child, Preschool MH - Triglycerides/blood MH - Risk Factors MH - Prevalence MH - Body Mass Index MH - Cholesterol, HDL/blood PMC - PMC12694549 OTO - NOTNLM OT - HOMA-IR OT - TG/HDL-C ratio OT - body composition OT - carotid intima-media thickness OT - insulin resistance OT - metabolic phenotypes OT - pediatric obesity OT - risk stratification OT - skeletal muscle mass COIS- The authors declare no conflicts of interest. EDAT- 2025/12/11 07:43 MHDA- 2025/12/11 07:44 PMCR- 2025/11/27 CRDT- 2025/12/11 01:04 PHST- 2025/10/27 00:00 [received] PHST- 2025/11/24 00:00 [revised] PHST- 2025/11/24 00:00 [accepted] PHST- 2025/12/11 07:44 [medline] PHST- 2025/12/11 07:43 [pubmed] PHST- 2025/12/11 01:04 [entrez] PHST- 2025/11/27 00:00 [pmc-release] AID - nu17233715 [pii] AID - nutrients-17-03715 [pii] AID - 10.3390/nu17233715 [doi] PST - epublish SO - Nutrients. 2025 Nov 27;17(23):3715. doi: 10.3390/nu17233715. PMID- 41374002 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20260127 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 23 DP - 2025 Nov 26 TI - Consumption of Unprocessed and Ultraprocessed Foods in Adolescents with Obesity: Associations with Neuroendocrine Mediators of Appetite Regulation and Binge Eating Symptoms. LID - 10.3390/nu17233711 [doi] LID - 3711 AB - Background/Objectives: Obesity is a multifactorial disease associated with increased consumption of ultraprocessed foods and reduced intake of unprocessed foods. Binge eating, one of the most prevalent eating disorders among adolescents, is closely linked to obesity. Food intake is regulated by both the hedonic system, responsible for reward responses, and the physiological system, which controls hunger and satiety through hormones, such as ghrelin and leptin. The present study aimed to investigate associations between the intake of unprocessed and ultraprocessed foods, neuroendocrine mediators of appetite regulation, and binge eating in adolescents with obesity. Methods: This cross-sectional study included 96 adolescents with obesity who were recruited in Sao Paulo, Brazil, between 2010 and 2012. Anthropometric and body composition assessments were performed. Binge eating symptoms were evaluated using the binge eating scale (BES), and dietary intake was assessed with a validated Food Frequency Questionnaire, with items classified according to the Nova system. Frequency data were converted into annual consumption scores. Serum levels of ghrelin, leptin, neuropeptide Y (NPY), agouti-related peptide (AgRP), melanin-concentrating hormone (MCH), and alpha-melanocyte-stimulating hormone (alpha-MSH) were analyzed. Results: Lower consumption of unprocessed foods was associated with higher ghrelin concentrations (p = 0.023), accompanied by a greater percentage of body fat (p = 0.047) and a reduced percentage of lean mass (p = 0.047) compared with adolescents in the second tertile. AgRP was a positive predictor of annual consumption score of ultraprocessed food (beta = 0.30; p = 0.04), independent of age, body fat, and binge eating symptoms. Conclusions: In conclusion, lower intake of unprocessed foods was associated with alterations in orexigenic and anorexigenic mediators, suggesting that dietary patterns in adolescents with obesity may influence the neuroendocrine mediators of appetite regulation. FAU - Neres, Patricia Sousa AU - Neres PS AD - Programa de Mestrado Profissional em Nutricao: do Nascimento a Adolescencia, Curso de Nutricao, Centro Universitario Sao Camilo (CUSC), Sao Paulo 05025-010, SP, Brazil. FAU - Ganen, Aline de Piano AU - Ganen AP AUID- ORCID: 0000-0001-6433-0816 AD - Programa de Mestrado Profissional em Nutricao: do Nascimento a Adolescencia, Curso de Nutricao, Centro Universitario Sao Camilo (CUSC), Sao Paulo 05025-010, SP, Brazil. FAU - Campos, Raquel Munhoz da Silveira AU - Campos RMDS AUID- ORCID: 0000-0001-6132-4349 AD - Programa de Pos-Graduacao Interdisciplinar em Ciencias da Saude, Departamento de Biociencias, Universidade Federal de Sao Paulo (UNIFESP), Campus Baixada Santista, Santos 11010-150, SP, Brazil. FAU - Carvalho Ferreira, Joana Pereira de AU - Carvalho Ferreira JP AUID- ORCID: 0000-0001-9038-2185 AD - Laboratorio Multidisciplinar em Alimentos e Saude, Faculdade de Ciencias Aplicadas, Universidade Estadual de Campinas (UNICAMP), Limeira 13484-350, SP, Brazil. FAU - Oyama, Lila Missae AU - Oyama LM AUID- ORCID: 0000-0002-7078-6526 AD - Programa de Pos-Graduacao em Nutricao, Departamento de Fisiologia, Universidade Federal de Sao Paulo (UNIFESP), Campus Sao Paulo, Sao Paulo 04023-061, SP, Brazil. FAU - Damaso, Ana Raimunda AU - Damaso AR AUID- ORCID: 0000-0001-7675-7470 AD - Programa de Pos-Graduacao em Nutricao, Departamento de Fisiologia, Universidade Federal de Sao Paulo (UNIFESP), Campus Sao Paulo, Sao Paulo 04023-061, SP, Brazil. FAU - Masquio, Deborah Cristina Landi AU - Masquio DCL AUID- ORCID: 0000-0003-0187-6402 AD - Programa de Mestrado Profissional em Nutricao: do Nascimento a Adolescencia, Curso de Nutricao, Centro Universitario Sao Camilo (CUSC), Sao Paulo 05025-010, SP, Brazil. AD - Programa de Pos-Graduacao em Nutricao, Departamento de Fisiologia, Universidade Federal de Sao Paulo (UNIFESP), Campus Sao Paulo, Sao Paulo 04023-061, SP, Brazil. LA - eng GR - 305240/2021-8/National Council for Scientific and Technological Development/ GR - 2566/2011/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior/ GR - 2006/00684-3; 2008/53069-0; 2011/50356-0; 2011/50414-0; 2013/041364/Fundacao de Amparo a Pesquisa do Estado de Sao Paulo/ PT - Journal Article DEP - 20251126 PL - Switzerland TA - Nutrients JT - Nutrients JID - 101521595 RN - 0 (Ghrelin) RN - 0 (Leptin) RN - 0 (Neuropeptide Y) RN - 581-05-5 (alpha-MSH) RN - 0 (Melanins) RN - 67382-96-1 (melanin-concentrating hormone) RN - 0 (Agouti-Related Protein) RN - 0 (Pituitary Hormones) RN - 0 (Hypothalamic Hormones) SB - IM MH - Humans MH - Adolescent MH - Female MH - Male MH - Cross-Sectional Studies MH - Ghrelin/blood MH - *Appetite Regulation/physiology MH - Leptin/blood MH - *Bulimia/blood MH - Brazil MH - *Pediatric Obesity/blood/physiopathology MH - Neuropeptide Y/blood MH - alpha-MSH/blood MH - Melanins/blood MH - Agouti-Related Protein/blood MH - Pituitary Hormones/blood MH - Feeding Behavior MH - *Fast Foods/adverse effects MH - Binge-Eating Disorder MH - Body Composition MH - *Diet MH - Hypothalamic Hormones PMC - PMC12694064 OTO - NOTNLM OT - adolescent OT - energy balance OT - neuroendocrine mediators OT - obesity OT - ultraprocessed food OT - unprocessed food COIS- The authors declare no conflicts of interest. EDAT- 2025/12/11 07:43 MHDA- 2025/12/11 07:44 PMCR- 2025/11/26 CRDT- 2025/12/11 01:04 PHST- 2025/09/25 00:00 [received] PHST- 2025/11/05 00:00 [revised] PHST- 2025/11/19 00:00 [accepted] PHST- 2025/12/11 07:44 [medline] PHST- 2025/12/11 07:43 [pubmed] PHST- 2025/12/11 01:04 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - nu17233711 [pii] AID - nutrients-17-03711 [pii] AID - 10.3390/nu17233711 [doi] PST - epublish SO - Nutrients. 2025 Nov 26;17(23):3711. doi: 10.3390/nu17233711. PMID- 41373943 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20251214 IS - 2072-6643 (Electronic) IS - 2072-6643 (Linking) VI - 17 IP - 23 DP - 2025 Nov 21 TI - Ultra-Processed Foods Consumption, Mediterranean Diet Adherence and Sociodemographic Correlates in an Italian Adult Population: The UFO Survey. LID - 10.3390/nu17233651 [doi] LID - 3651 AB - Background: Although national surveys report increasing ultra-processed foods (UPFs) consumption, updated estimates for Italy are lacking. Given the central role of the Mediterranean Diet (MD), understanding how UPFs contribute to the contemporary Italian diet is essential. This study quantified UPF intake in a convenience sample of Italian adults and examined its main sociodemographic correlates, including MD adherence. Methods: A web-based cross-sectional survey was conducted among Italian adults (>/=18 years). Dietary intake was assessed using the validated 94-item NOVA Food Frequency Questionnaire (NFFQ). Associations between sociodemographic factors and NOVA food groups were evaluated using multivariable-adjusted linear regression, expressed as beta coefficients (beta) and 95% confidence intervals (95% CI). MD adherence was assessed using the Medi-Lite score. Results: Data from 1629 participants (79.8% women; mean age 42.1 years, range 18-85) recruited between September 2021 and April 2025 were analyzed. Participants resided in Northern (23.4%), Central (40.4%), and Southern Italy (36.2%). UPFs contributed 20.0% (95% CI: 19.5-20.6) of total energy intake, while unprocessed/minimally processed foods, processed culinary ingredients, and processed foods accounted for 39.2%, 9.0%, and 31.8%, respectively. UPF consumption decreased with age (beta = -3.34; 95% CI: -5.96 to -0.72 for >64 vs. 0.05). The PNR demonstrates a significant association with HU use and HbF levels, indicating its potential as a low-cost, accessible biomarker for monitoring HU therapy in SCD. Although this analysis was based on data from a high-resource setting, the findings underscore the relevance of PNR as a feasible monitoring alternative in resource-constrained environments. Further validation in low-income contexts is warranted to establish population-specific reference intervals and inform clinical practice. CI - (c) 2025. The Author(s). FAU - Chibuife, Efobi Chilota AU - Chibuife EC AD - Department of Haematology and Blood Transfusion, Faculty of Basic Clinical Sciences, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria. FAU - Chisom Adaobi, Nri-Ezedi AU - Chisom Adaobi NE AD - Department of Paediatrics, Faculty of Medicine, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria. ca.nri-ezedi@unizik.edu.ng. AD - Department of Paediatrics, Nnamdi Azikiwe University, Awka, Anambra, Nigeria. ca.nri-ezedi@unizik.edu.ng. FAU - Odini, Franklin AU - Odini F AD - Department of Community Medicine, Federal Medical Centre, Umuahia, Abia State, Nigeria. FAU - Deepika, Habib Darbari AU - Deepika HD AD - Division of Hematology, Children's National Hospital and George Washington University School of Medicine and Health Sciences, Washington, DC, USA. FAU - Habib, Nana-Bilkisu AU - Habib NB AD - Division of Hematology, Children's National Hospital and George Washington University School of Medicine and Health Sciences, Washington, DC, USA. FAU - Andrew, Campbell AU - Andrew C AD - Division of Hematology, Children's National Hospital and George Washington University School of Medicine and Health Sciences, Washington, DC, USA. LA - eng PT - Journal Article DEP - 20251210 PL - Germany TA - Ann Hematol JT - Annals of hematology JID - 9107334 RN - X6Q56QN5QC (Hydroxyurea) RN - 9034-63-3 (Fetal Hemoglobin) RN - 0 (Biomarkers) RN - 0 (Antisickling Agents) SB - IM MH - Humans MH - *Hydroxyurea/therapeutic use MH - *Anemia, Sickle Cell/drug therapy/blood/economics/epidemiology MH - Male MH - Female MH - *Neutrophils MH - Retrospective Studies MH - Child MH - Adolescent MH - Fetal Hemoglobin/analysis MH - *Blood Platelets MH - Child, Preschool MH - Platelet Count MH - Nigeria/epidemiology MH - Developing Countries MH - Poverty MH - *Drug Monitoring/methods MH - Biomarkers/blood MH - Antisickling Agents/therapeutic use PMC - PMC12764571 OTO - NOTNLM OT - Foetal haemoglobin OT - Hydroxyurea OT - Low-resource settings OT - Platelet-to-neutrophil ratio OT - Sickle cell disease COIS- Declarations. Ethical approval: Ethical approval for the study was obtained from the institutional review board (IRB) at Children's National Hospital, Washington DC, United States of America.. IRB number: Pro00010744 Consent to participate: As this was a retrospective chart review using de-identified data, individual patient consent was waived by the IRB in accordance with ethical regulations and the principles outlined in the Declaration of Helsinki. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/10 13:51 MHDA- 2026/01/04 06:36 PMCR- 2025/12/10 CRDT- 2025/12/10 11:22 PHST- 2025/06/01 00:00 [received] PHST- 2025/08/22 00:00 [accepted] PHST- 2026/01/04 06:36 [medline] PHST- 2025/12/10 13:51 [pubmed] PHST- 2025/12/10 11:22 [entrez] PHST- 2025/12/10 00:00 [pmc-release] AID - 10.1007/s00277-025-06598-2 [pii] AID - 6598 [pii] AID - 10.1007/s00277-025-06598-2 [doi] PST - ppublish SO - Ann Hematol. 2025 Dec;104(12):6161-6168. doi: 10.1007/s00277-025-06598-2. Epub 2025 Dec 10. PMID- 41369874 OWN - NLM STAT- MEDLINE DCOM- 20260224 LR - 20261009 IS - 0973-7693 (Electronic) IS - 0019-5456 (Linking) VI - 93 IP - 3 DP - 2026 Mar TI - Optimizing Mid-Upper Arm Circumference (MUAC) Thresholds for Screening Wasting and Severe Wasting in Children Aged 6-59 Months in Community Settings in India. PG - 253-258 LID - 10.1007/s12098-025-05869-0 [doi] AB - OBJECTIVES: To identify suitable mid-upper arm circumference (MUAC) thresholds for screening wasting and severe wasting among children in India. METHODS: Community-based cross-sectional studies were conducted in five districts from four Indian states- Jharkhand, Odisha, Uttar Pradesh, and Madhya Pradesh. Anthropometric measurements of 2,335 children aged 6-59 mo were taken. RESULTS: Wasting [Weight-for-height Z-score (WHZ) <-2] and severe wasting (WHZ <-3) prevalence were found to be 30.9% and 5.5%, respectively. A strong correlation [0.72 (95% CI: 0.69, 0.74; P < 0.001)] between MUAC and WHZ was observed. However, Cohen's Kappa coefficients of 0.28 (P < 0.001) and 0.36 (P < 0.001) suggested a lack of strong agreement between the current WHZ and MUAC thresholds for detecting wasting and severe wasting. ROC analyses for identifying severe wasting indicated that MUAC of 12.8 cm was appropriate for children aged 6-59 mo (sensitivity: 0.80, specificity: 0.87, AUC: 0.91; 95% CI: 0.89, 0.93). For children 6-23 mo and 24-59 mo, MUAC of 12.7 cm and 13.3 cm respectively were suitable. For identifying wasting, the appropriate MUAC cut-offs were 13.8 cm for children 6-59 mo (sensitivity: 0.82, specificity: 0.69, AUC: 0.84; 95% CI: 0.82, 0.86), 13.1 cm for children 6-23 mo, and 13.8 cm for children 24-59 mo. CONCLUSIONS: MUAC is a reliable indicator of WHZ for children 6-59 mo in India. In under-resourced areas where measuring WHZ may be challenging, MUAC cut-offs of < 14.0 cm for wasting and < 13.0 cm for severe wasting can be used for initial screening. Further assessment using WHZ can follow MUAC screening. CI - (c) 2025. The Author(s), under exclusive licence to Dr. K C Chaudhuri Foundation. FAU - Sinha, Rajesh Kumar AU - Sinha RK AUID- ORCID: 0000-0002-0428-8457 AD - Department of Finance, Jaipuria Institute of Management, Jaipur, Rajasthan, India. cmarajesh@gmail.com. FAU - Kumar, Praveen AU - Kumar P AD - Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India. FAU - Seth, Anju AU - Seth A AD - Department of Pediatrics, Lady Hardinge Medical College and Associated Kalawati Saran Children's Hospital, New Delhi, India. LA - eng GR - UNICEF/UNICEF/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251210 PL - India TA - Indian J Pediatr JT - Indian journal of pediatrics JID - 0417442 SB - IM MH - Humans MH - India/epidemiology MH - *Arm/anatomy & histology MH - Child, Preschool MH - Infant MH - Cross-Sectional Studies MH - *Wasting Syndrome/diagnosis/epidemiology MH - Male MH - Female MH - *Anthropometry/methods MH - Mass Screening/methods MH - Prevalence MH - Sensitivity and Specificity OTO - NOTNLM OT - Acute malnutrition OT - Mid-upper arm circumference (MUAC) OT - Severe wasting OT - Wasting OT - Weight-for-height Z-score (WHZ) COIS- Declarations. Conflict of Interest: None. EDAT- 2025/12/10 13:52 MHDA- 2026/02/24 18:45 CRDT- 2025/12/10 11:21 PHST- 2025/05/11 00:00 [received] PHST- 2025/11/04 00:00 [accepted] PHST- 2026/02/24 18:45 [medline] PHST- 2025/12/10 13:52 [pubmed] PHST- 2025/12/10 11:21 [entrez] AID - 10.1007/s12098-025-05869-0 [pii] AID - 10.1007/s12098-025-05869-0 [doi] PST - ppublish SO - Indian J Pediatr. 2026 Mar;93(3):253-258. doi: 10.1007/s12098-025-05869-0. Epub 2025 Dec 10. PMID- 41369522 OWN - NLM STAT- MEDLINE DCOM- 20260128 LR - 20260920 IS - 2638-6100 (Electronic) IS - 2638-6100 (Linking) VI - 8 IP - 1 DP - 2026 Jan TI - Reference Trajectories of Extra-Axial Cerebrospinal Fluid during Childhood and Adolescence Defined in a Clinically Acquired MRI Dataset. PG - e250123 LID - 10.1148/ryai.250123 [doi] LID - e250123 AB - Purpose To build extra-axial cerebrospinal fluid (eaCSF) growth charts that define key diagnostic criteria for benign enlargement of the subarachnoid space (BESS) by providing an age-related reference benchmark to aid in assessing atypical eaCSF development. Materials and Methods In this retrospective study, T1-weighted MRI scans from patients who underwent imaging at a pediatric health care system between January 2004 and December 2023 were accessed to form a clinical control group. Nine scans from patients diagnosed with BESS by a board-certified pediatric neuroradiologist were also reviewed. T1-weighted scans were segmented into various tissue types, including eaCSF. Growth charts of eaCSF were modeled using the clinical control group. The results of patients with confirmed BESS were then benchmarked against these charts to test the performance of the eaCSF growth charts. Generalized additive models of location, scale, and shape were used. Results The eaCSF measurements were obtained for 1205 patients (619 female; age range, 0.19-19.6 years). Measurements show that eaCSF evolved dynamically with age, steadily decreasing from birth to 2 years, then trending upward in childhood. Seven of the nine patients with a clinical diagnosis of BESS had eaCSF measurements above the 97.5th percentile for at least one measurement. Percentile scores distinguished patients with BESS from controls with areas under the receiver operating characteristic curve of greater than 0.95. Conclusion MRI-derived eaCSF measurements evolved dynamically throughout early life. Patients with atypical CSF development could be differentiated from clinical controls using computational measurements paired with normative modeling. Keywords: MRI, Brain/Brain Stem, Pediatrics, Benign Enlargement of Subarachnoid Space Supplemental material is available for this article. (c) The Author(s) 2025. Published by the Radiological Society of North America under a CC BY-NC-ND license. FAU - Mandal, Ayan S AU - Mandal AS AUID- ORCID: 0000-0002-0780-3864 AD - Perelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd, Philadelphia, PA 19104. AD - Department of Child and Adolescent Psychiatry and Behavioral Science, The Children's Hospital of Philadelphia, Philadelphia, Pa. AD - Lifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia, Pa. FAU - Dorfschmidt, Lena AU - Dorfschmidt L AUID- ORCID: 0000-0002-0447-1104 AD - Department of Child and Adolescent Psychiatry and Behavioral Science, The Children's Hospital of Philadelphia, Philadelphia, Pa. AD - Lifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia, Pa. FAU - Schabdach, Jenna M AU - Schabdach JM AUID- ORCID: 0000-0003-3923-5846 AD - Department of Child and Adolescent Psychiatry and Behavioral Science, The Children's Hospital of Philadelphia, Philadelphia, Pa. AD - Lifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia, Pa. FAU - Gardner, Margaret AU - Gardner M AUID- ORCID: 0000-0002-4498-0827 AD - Department of Child and Adolescent Psychiatry and Behavioral Science, The Children's Hospital of Philadelphia, Philadelphia, Pa. AD - Lifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia, Pa. FAU - Yerys, Benjamin E AU - Yerys BE AD - Department of Child and Adolescent Psychiatry and Behavioral Science, The Children's Hospital of Philadelphia, Philadelphia, Pa. AD - Center for Autism Research, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia, Pa. AD - Advancing Transition and Learning for Adult Success Center, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia, Pa. FAU - Bethlehem, Richard A I AU - Bethlehem RAI AUID- ORCID: 0000-0002-0714-0685 AD - Department of Psychology, University of Cambridge, Cambridge, UK. FAU - Sotardi, Susan AU - Sotardi S AUID- ORCID: 0000-0001-8389-2419 AD - Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pa. FAU - Henry, M Katherine AU - Henry MK AD - Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pa. AD - Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa. AD - Clinical Futures, The Children's Hospital of Philadelphia, Philadelphia, Pa. FAU - Wood, Joanne N AU - Wood JN AUID- ORCID: 0000-0001-6431-8024 AD - Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa. AD - Clinical Futures, The Children's Hospital of Philadelphia, Philadelphia, Pa. FAU - Chaiyachati, Barbara H AU - Chaiyachati BH AUID- ORCID: 0000-0001-7324-6245 AD - Lifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia, Pa. AD - Department of Pediatrics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pa. AD - Clinical Futures, The Children's Hospital of Philadelphia, Philadelphia, Pa. FAU - Alexander-Bloch, Aaron AU - Alexander-Bloch A AUID- ORCID: 0000-0001-6554-1893 AD - Department of Child and Adolescent Psychiatry and Behavioral Science, The Children's Hospital of Philadelphia, Philadelphia, Pa. AD - Lifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia, Pa. AD - Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa. FAU - Seidlitz, Jakob AU - Seidlitz J AUID- ORCID: 0000-0002-8164-7476 AD - Department of Child and Adolescent Psychiatry and Behavioral Science, The Children's Hospital of Philadelphia, Philadelphia, Pa. AD - Lifespan Brain Institute, The Children's Hospital of Philadelphia and Penn Medicine, Philadelphia, Pa. AD - Department of Psychiatry, University of Pennsylvania, Philadelphia, Pa. LA - eng GR - R24 HD098415/HD/NICHD NIH HHS/United States GR - R01 MH133843/MH/NIMH NIH HHS/United States GR - F32 MH012977/MH/NIMH NIH HHS/United States GR - K08 MH129657/MH/NIMH NIH HHS/United States GR - R01 MH134896/MH/NIMH NIH HHS/United States GR - R21 MH129777/MH/NIMH NIH HHS/United States GR - R01 MH133838/MH/NIMH NIH HHS/United States GR - K08 HS028847/HS/AHRQ HHS/United States GR - P50 HD105354/HD/NICHD NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, U.S. Gov't, P.H.S. PL - United States TA - Radiol Artif Intell JT - Radiology. Artificial intelligence JID - 101746556 SB - IM UOF - medRxiv. 2024 Sep 26:2024.09.24.24314251. doi: 10.1101/2024.09.24.24314251. PMID: 39399011 MH - Humans MH - Child MH - *Magnetic Resonance Imaging/methods MH - Adolescent MH - Female MH - Infant MH - Child, Preschool MH - Male MH - Retrospective Studies MH - *Cerebrospinal Fluid/diagnostic imaging MH - Young Adult MH - *Subarachnoid Space/diagnostic imaging/growth & development MH - Reference Values MH - Infant, Newborn MH - Growth Charts PMC - PMC12856361 MID - NIHMS2130345 OTO - NOTNLM OT - Benign Enlargement of Subarachnoid Space OT - Brain/Brain Stem OT - MRI OT - Pediatrics COIS- Please see ICMJE form(s) for author conflicts of interest. These have been provided as supplemental materials EDAT- 2025/12/10 13:51 MHDA- 2026/01/28 19:20 PMCR- 2025/12/10 CRDT- 2025/12/10 09:53 PHST- 2026/01/28 19:20 [medline] PHST- 2025/12/10 13:51 [pubmed] PHST- 2025/12/10 09:53 [entrez] PHST- 2025/12/10 00:00 [pmc-release] AID - 10.1148/ryai.250123 [doi] PST - ppublish SO - Radiol Artif Intell. 2026 Jan;8(1):e250123. doi: 10.1148/ryai.250123. PMID- 41368537 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251210 LR - 20251210 IS - 0734-0451 (Print) IS - 1098-8955 (Electronic) IS - 0734-0451 (Linking) VI - 46 IP - 4 DP - 2025 Nov TI - Exploring the Feasibility of an Adapted Home-Based Video Exercise Program for Primary School-Aged Children in Malaysia: A Preliminary Investigation. PG - 272-285 LID - 10.1055/s-0045-1812879 [doi] AB - INTRODUCTION: Vestibular rehabilitation therapy (VRT) has demonstrated effectiveness in adults; however, evidence supporting its use in children remains limited. Given the potential developmental impacts of vestibular-related problems, it is essential to identify accessible and age-appropriate strategies for targeted rehabilitation in pediatric populations. In Malaysia, access to physical therapists trained in vestibular rehabilitation for children is limited, and logistical barriers often hinder regular clinic attendance. These challenges underscore the need for a home-based alternative. OBJECTIVE: This study aimed to adapt and evaluate the feasibility of a home-based video exercise program (HBVEP) for children aged 7 to 12 years old. RESULTS: The structured feasibility questionnaire revealed strong parental endorsement, with most responses ranging from "agree" to "completely agree" regarding the exercise program's acceptability, appropriateness, and feasibility. Completion time data indicated that the exercises were manageable, and analysis of exercise preferences offered insight into which components were most engaging for children and parents. CONCLUSION: The results support the practicality of the HBVEP as a targeted rehabilitation approach for school-aged children. It offers a flexible, low-cost alternative to in-clinic therapy. However, further research involving children with vestibular and balance impairments is needed to assess the full clinical utility and effectiveness of this intervention. CI - Thieme. All rights reserved. FAU - Abdul Wahat, Nor Haniza AU - Abdul Wahat NH AD - Center for Rehabilitation and Special Needs Studies (iCaRehab), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. FAU - Khairol Anur, Nur Dini Izzati AU - Khairol Anur NDI AD - Center for Rehabilitation and Special Needs Studies (iCaRehab), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. FAU - Zanuddin, Nor Asfarina AU - Zanuddin NA AD - Center for Rehabilitation and Special Needs Studies (iCaRehab), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. FAU - Rantai, Vivian Sheereen Anak AU - Rantai VSA AD - Center for Rehabilitation and Special Needs Studies (iCaRehab), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. FAU - Jamaluddin, Mohd Khairil Azahar AU - Jamaluddin MKA AD - Center for Rehabilitation and Special Needs Studies (iCaRehab), Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia. LA - eng PT - Journal Article PT - Review DEP - 20251105 PL - United States TA - Semin Hear JT - Seminars in hearing JID - 8413380 PMC - PMC12685444 OTO - NOTNLM OT - children OT - feasibility OT - home-based exercise module OT - pediatric audiology OT - vestibular rehabilitation therapy COIS- Conflict of Interest None declared. EDAT- 2025/12/10 06:28 MHDA- 2025/12/10 06:29 PMCR- 2026/11/05 CRDT- 2025/12/10 04:55 PHST- 2025/12/10 06:29 [medline] PHST- 2025/12/10 06:28 [pubmed] PHST- 2025/12/10 04:55 [entrez] PHST- 2026/11/05 00:00 [pmc-release] AID - sih001037 [pii] AID - 10.1055/s-0045-1812879 [doi] PST - epublish SO - Semin Hear. 2025 Nov 5;46(4):272-285. doi: 10.1055/s-0045-1812879. eCollection 2025 Nov. PMID- 41367997 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251210 LR - 20251212 IS - 2949-7329 (Electronic) IS - 2949-7329 (Linking) VI - 3 IP - 4 DP - 2025 Dec TI - Wearable Signals for Diagnosing Attention-Deficit/Hyperactivity Disorder in Adolescents: A Feasibility Study. PG - 875-889 LID - 10.1016/j.jaacop.2024.11.003 [doi] AB - OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder in children and adolescents. Diagnoses of ADHD often rely on subjective ratings from parents and teachers. This study investigated the feasibility of using objective activity monitoring data collected through wearable activity trackers for ADHD diagnosis and monitoring in adolescents. METHOD: A longitudinal study was conducted involving Chinese adolescents ages 16 to 17 years. Data collected included objective measures (movement acceleration, heart rate, and sleep patterns from passive actigraphy) and subjective measures (parent and self-reported questionnaires). Machine learning models were developed using eXtreme Gradient Boosting (XGBoost) to compare various measures for ADHD classification. Model performance was evaluated using the area under the receiver operating characteristics curve (AUC). The SHapley Additive exPlanations (SHAP) method was used to analyze the importance of different measures on ADHD risk. RESULTS: The study included 30 adolescents (17 with ADHD and 13 without ADHD). Machine learning models using solely objective measures achieved high predictability in classifying ADHD (AUC = 0.844) and ADHD medication status (AUC = 1.000). Models integrating both subjective and objective measures showed enhanced performance (AUC = 0.933). In this sample, key features for ADHD classification included irritability, sex, and quality-of-life indicators; key features for ADHD medication use classification included heart rate and physical activity intensity. CONCLUSION: Although the sample size was small, actigraphy-based monitoring provides a noninvasive and granular measurement of objective vital signs of adolescents. If validated in larger samples, the incorporation of objective measures is likely to enhance multidimensional assessment and diagnostic accuracy in adolescents with ADHD, supplementing existing diagnostic methods. STUDY PREREGISTRATION INFORMATION: A systematic review of anhedonia and amotivation in depression and cannabis use; https://www.crd.york.ac.uk/prospero/; CRD42023422438. CI - (c) 2024 The Authors. FAU - Jiang, Zhihan AU - Jiang Z AD - Faculty of Engineering, The University of Hong Kong, Hong Kong SAR, China. FAU - Chan, Adrienne Y L AU - Chan AYL AD - Groningen Research Institute of Pharmacy, Unit of Pharmacotherapy Epidemiology and Economics, University of Groningen, Groningen, The Netherlands. AD - Laboratory of Data Discovery for Health (D24H), The University of Hong Kong, Hong Kong SAR, China. AD - School of Pharmacy, University College London, London, United Kingdom. AD - Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. FAU - Lum, Dawn AU - Lum D AD - Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. FAU - Wong, Kirstie H T W AU - Wong KHTW AD - School of Pharmacy, University College London, London, United Kingdom. AD - Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. AD - Hong Kong Children's Hospital, Hong Kong SAR, China. FAU - Leung, Janice C N AU - Leung JCN AD - Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. FAU - Ip, Patrick AU - Ip P AD - Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. AD - Hong Kong Children's Hospital, Hong Kong SAR, China. FAU - Coghill, David AU - Coghill D AD - University of Melbourne, Melbourne, Victoria, Australia. FAU - Wong, Rosa S AU - Wong RS AD - Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. FAU - Ngai, Edith C H AU - Ngai ECH AD - Faculty of Engineering, The University of Hong Kong, Hong Kong SAR, China. FAU - Wong, Ian C K AU - Wong ICK AD - Laboratory of Data Discovery for Health (D24H), The University of Hong Kong, Hong Kong SAR, China. AD - School of Pharmacy, University College London, London, United Kingdom. AD - Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China. AD - Aston School of Pharmacy, Aston University, Birmingham, United Kingdom. LA - eng PT - Journal Article DEP - 20241125 PL - United States TA - JAACAP Open JT - JAACAP open JID - 9918627288306676 PMC - PMC12684460 OAB - This study explores the feasibility of using commercial wrist-worn activity trackers in addition to parent- and self-report questionnaires to diagnose and monitor attention-deficit/hyperactivity disorder (ADHD) in Chinese adolescents. The data collected from 30 adolescents (17 with ADHD and 13 without ADHD) for 12 weeks, including movement patterns and heart rate, were used to develop machine learning models for ADHD identification and medication status classification. The experimental results combined and compared with traditional parent- and self-report questionnaires suggest that wearable trackers could offer an objective way to assess ADHD, potentially supplementing existing diagnostic methods and monitoring for this condition. If validated in larger samples, the incorporation of objective measures is likely to enhance multidimensional assessment and diagnostic accuracy in adolescents with ADHD. OABL- eng OTO - NOTNLM OT - ADHD OT - activity monitoring OT - machine learning OT - wearable devices EDAT- 2025/12/10 06:28 MHDA- 2025/12/10 06:29 PMCR- 2024/11/25 CRDT- 2025/12/10 04:49 PHST- 2024/11/18 00:00 [accepted] PHST- 2025/12/10 06:29 [medline] PHST- 2025/12/10 06:28 [pubmed] PHST- 2025/12/10 04:49 [entrez] PHST- 2024/11/25 00:00 [pmc-release] AID - S2949-7329(24)00091-7 [pii] AID - 10.1016/j.jaacop.2024.11.003 [doi] PST - epublish SO - JAACAP Open. 2024 Nov 25;3(4):875-889. doi: 10.1016/j.jaacop.2024.11.003. eCollection 2025 Dec. PMID- 41367939 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251210 LR - 20251212 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 16 DP - 2025 TI - Loneliness and nervousness mediated the longitudinal association between sleep disorders and cyberbullying victimization in school-aged adolescents. PG - 1640989 LID - 10.3389/fpsyt.2025.1640989 [doi] LID - 1640989 AB - BACKGROUND: This study investigated the longitudinal dose-response relationship between sleep disorders and cyberbullying victimization in school-aged adolescents and explored the mediating roles of psychological factors (loneliness, sadness, and nervousness). METHODS: A 2-year longitudinal design was used to collect self-reported data on sleep disorders, physical activity, screen time, smoking, alcohol use, and dieting behavior. Cyberbullying victimization was assessed during follow-up. Multivariate logistic regression analysis and restricted cubic splines (RCSs) were used to analyze the dose-response relationship between sleep disorders and cyberbullying victimization. The mediation analysis explored indirect effects through loneliness, sadness, and nervousness. RESULTS: Among the 1,910 adolescents (mean age: 12.2 +/- 0.47 years), the mean sleep disorder score was 3.32 +/- 3.68 (range: 0-27.0), and 196 (10.3%) engaged in cyberbullying victimization during the follow-up period. Sleep disorders were significantly associated with an increased risk of cyberbullying victimization (OR: 1.10, 95% CI: 1.06-1.14) after adjusting for confounders. Sensitivity analyses further validated the robustness of the results, which revealed that the risk of cyberbullying victimization increased approximately with increasing prevalence of sleep disorders. The RCS curve revealed that the risk of cyberbullying victimization increased approximately linearly with increasing prevalence of sleep disorders (P for overall<0.001, P for nonlinear=0.915). Compared with boys, girls with more sleep disorders presented a slightly greater risk of cyberbullying victimization (adjusted OR: 1.14 vs.1.08). Loneliness and nervousness partially mediated the association between sleep disorders and cyberbullying victimization, accounting for 25.00% (indirect effect beta = 0.003, P < 0.001) and 8.33% (indirect effect beta = 0.001, P = 0.038) of the total effect, whereas sadness had no significant effect. CONCLUSIONS: Sleep disorders independently predict cyberbullying victimization in adolescents, with stronger effects observed in girls. Loneliness and nervousness partially mediate this association. Targeted interventions to improve sleep, reduce loneliness and nervousness, and sex-specific strategies may mitigate cyberbullying victimization in school-aged adolescents. CI - Copyright (c) 2025 Xiao, Jiang, Lei, Wang, Li and Gong. FAU - Xiao, Xin AU - Xiao X AD - Visual Science and Optometry Center of Guangxi, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. AD - Scientific Research Department, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. AD - Guangxi Key Laboratory of Eye Health, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. AD - Guangxi Health Commission Key Laboratory of Ophthalmology and Related Systemic Diseases Artificial Intelligence Screening Technology, The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China. FAU - Jiang, Zu-Ling AU - Jiang ZL AD - Scientific Research Department, The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, Guangxi, China. FAU - Lei, Qiong AU - Lei Q AD - Department of Ophthalmology, Nanxishan Hospital of Guangxi Zhuang Autonomous Region, Guilin, Guangxi, China. FAU - Wang, Si-Jia AU - Wang SJ AD - Department of School Health, Ningbo Municipal Center for Disease Control and Prevention, Ningbo, Zhejiang, China. FAU - Li, Si-Xuan AU - Li SX AD - Department of School Health, Ningbo Municipal Center for Disease Control and Prevention, Ningbo, Zhejiang, China. FAU - Gong, Qing-Hai AU - Gong QH AD - Department of School Health, Ningbo Municipal Center for Disease Control and Prevention, Ningbo, Zhejiang, China. LA - eng PT - Journal Article DEP - 20251124 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC12682890 OTO - NOTNLM OT - adolescents OT - cyberbullying victimization OT - loneliness OT - mediation effect OT - nervousness OT - sleep disorders COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/10 06:28 MHDA- 2025/12/10 06:29 PMCR- 2025/11/24 CRDT- 2025/12/10 04:49 PHST- 2025/06/04 00:00 [received] PHST- 2025/10/30 00:00 [accepted] PHST- 2025/12/10 06:29 [medline] PHST- 2025/12/10 06:28 [pubmed] PHST- 2025/12/10 04:49 [entrez] PHST- 2025/11/24 00:00 [pmc-release] AID - 10.3389/fpsyt.2025.1640989 [doi] PST - epublish SO - Front Psychiatry. 2025 Nov 24;16:1640989. doi: 10.3389/fpsyt.2025.1640989. eCollection 2025. PMID- 41367598 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251210 LR - 20251212 IS - 2352-0132 (Electronic) IS - 2096-6296 (Print) IS - 2352-0132 (Linking) VI - 12 IP - 6 DP - 2025 Nov TI - Increasing breastfeeding literacy: A preliminary study to develop an AI-based chatbot. PG - 509-515 LID - 10.1016/j.ijnss.2025.10.013 [doi] AB - OBJECTIVES: Breastfeeding plays a critical role in the healthy development of infants, yet exclusive breastfeeding (EBF) rates remain low, particularly among low-income mothers. This study aimed to develop and validate an AI-based educational innovative solution to increase breastfeeding literacy across caregivers and mothers. METHODS: The BabyChat (AI-based) was developed through two phases. In phase I, the content was created using the Canvas application, with the idea tree structured through MindMeister, and delivered via the ManyChat tool on Facebook. The focus was on the benefits of EBF during the initial 6 months of life, as recommended by the WHO, and continued breastfeeding until 1,000 days of life. In Phase II, functionality tests were performed using UserTesting and subsequently validated by the Content Validity Index (CVI). Healthcare professionals reviewed the clarity and relevance of the information on a four-point scale. Intra-examiner concordance was assessed by percentage of agreement and the median for each CVI-I point. RESULTS: The contents of BabyChat included 8 topics and 18 subtopics (based on relevant contents including nutritional and anatomical aspects, weaning strategies among others) aimed to educate mothers and caregivers. Five mothers participated in evaluation of the BabyChat. Overall, most participants found the chatbot's question-and-answer functionality clear and helpful, with accurate command execution and timely response speeds, etc. However, two participants noted occasional issues such as misinterpreted questions, delayed command responses, and unclear or hard-to-find interface buttons. A total of four experts in psychology, dentistry, and medicine validated the framework. The agreement rate between experts ranged from 25 % to 100 %, with median values between 3 and 4, indicating excellent content relevance. CONCLUSION: The BabyChat was developed and validated for use in increasing breastfeeding literacy among caregivers and mothers. Future studies should be considered to expand the BabyChat validation to other healthcare professionals, including nursing staff, to comprehensively capture the impact of BabyChat on mothers, as well as to incorporate population-specific topics that depend on cultural and geographical aspects. CI - (c) 2025 The Authors. FAU - Kantovitz, Kamila Rosamilia AU - Kantovitz KR AD - School of Dentistry, University of Maryland, Baltimore, MD, USA. AD - Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. FAU - Mattoso, Maria Eduarda AU - Mattoso ME AD - Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. FAU - Meyer, Maria Davoli AU - Meyer MD AD - Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. FAU - de Araujo, Marcella Armbruster AU - de Araujo MA AD - Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. FAU - Giovani, Priscila Alves AU - Giovani PA AD - Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. FAU - Martinez, Valentin AU - Martinez V AD - Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. FAU - Dubey, Nileshkumar AU - Dubey N AD - School of Dentistry, University of Maryland, Baltimore, MD, USA. FAU - Nociti, Francisco Humberto Jr AU - Nociti FH Jr AD - School of Dentistry, University of Maryland, Baltimore, MD, USA. AD - Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. FAU - Motta, Rogerio Heladio Lopes AU - Motta RHL AD - Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. LA - eng PT - Journal Article DEP - 20251027 PL - China TA - Int J Nurs Sci JT - International journal of nursing sciences JID - 101660887 PMC - PMC12684757 OTO - NOTNLM OT - Artificial intelligence OT - Breast feeding OT - Communication OT - Education OT - Knowledge COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/10 06:28 MHDA- 2025/12/10 06:29 PMCR- 2025/10/27 CRDT- 2025/12/10 04:46 PHST- 2025/06/21 00:00 [received] PHST- 2025/10/23 00:00 [revised] PHST- 2025/10/25 00:00 [accepted] PHST- 2025/12/10 06:29 [medline] PHST- 2025/12/10 06:28 [pubmed] PHST- 2025/12/10 04:46 [entrez] PHST- 2025/10/27 00:00 [pmc-release] AID - S2352-0132(25)00136-X [pii] AID - 10.1016/j.ijnss.2025.10.013 [doi] PST - epublish SO - Int J Nurs Sci. 2025 Oct 27;12(6):509-515. doi: 10.1016/j.ijnss.2025.10.013. eCollection 2025 Nov. PMID- 41367538 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251210 LR - 20251212 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 14 IP - 11 DP - 2025 Nov 30 TI - Nocturnal hypertension predicts left ventricular hypertrophy in children with primary hypertension. PG - 3011-3019 LID - 10.21037/tp-2025-567 [doi] AB - BACKGROUND: Childhood hypertension is a significant global health concern, with left ventricular hypertrophy (LVH) being its most common target organ damage. Evidence from Chinese pediatric populations remains scarce. Therefore, this study aimed to investigate the risk factors of LVH in children with primary hypertension and to develop a prediction model. METHODS: In this cross-sectional study, 121 children diagnosed with primary hypertension (aged 3-17 years) admitted to Children's Hospital of Fudan University (January 1, 2019-December 31, 2024) were included. Clinical data (age, sex, height, weight, birth history, and family history of hypertension), laboratory parameters, 24-hour ambulatory blood pressure monitoring (ABPM), and echocardiography were collected. Participants were stratified into the LVH group and the non-LVH group based on left ventricular mass index (LVMI). Partial correlation analysis evaluated associations of variables with left ventricular mass and LVMI. Stepwise multivariable logistic regression was used to identify independent risk factors. Based on significant factors, a risk prediction model was constructed, with model performance assessed via receiver operating characteristic (ROC) curves [area under the curve (AUC)] and goodness-of-fit tests (Hosmer-Lemeshow chi(2)). RESULTS: LVH was observed in 17.4% (21/121) of participants, predominantly concentric hypertrophy. Partial correlation analysis adjusted for age and sex revealed positive correlations of alanine aminotransferase (ALT), aspartate aminotransferase (AST), 24-hour mean systolic blood pressure (SBP), daytime mean SBP, and morning mean SBP (the average of ambulatory SBP readings taken within 2 hours of waking up) with LVMI (r=0.26, 0.37, 0.25, 0.25, and 0.23, all P<0.05), respectively. Nocturnal hypertension was identified as an independent risk factor of LVH [odds ratio (OR) =4.07; 95% confidence interval (CI): 1.47-13.24; P=0.01]. The combined prediction model incorporating age, sex, body mass index (BMI), and nocturnal hypertension demonstrated a moderate discrimination (AUC =0.710; 95% CI: 0.593-0.827) and good calibration (Hosmer-Lemeshow chi(2)=5.70; P=0.68). CONCLUSIONS: This study identified nocturnal hypertension as a critical independent risk factor for LVH in pediatric primary hypertension. The prediction model may provide valuable insights for early identification of LVH. CI - (c) AME Publishing Company. FAU - Wang, Jiayu AU - Wang J AUID- ORCID: 0000-0002-5608-0738 AD - National Health Commission Key Laboratory of Neonatal Diseases (Fudan University), Shanghai, China. AD - Institute of Pediatrics, Children's Hospital of Fudan University, Shanghai, China. FAU - Zhang, Jialing AU - Zhang J AD - National Health Commission Key Laboratory of Neonatal Diseases (Fudan University), Shanghai, China. AD - Institute of Pediatrics, Children's Hospital of Fudan University, Shanghai, China. FAU - Chu, Chen AU - Chu C AD - Heart Center, Children's Hospital of Fudan University, Shanghai, China. FAU - Wang, Jie AU - Wang J AD - Heart Center, Children's Hospital of Fudan University, Shanghai, China. FAU - Liu, Fang AU - Liu F AD - Heart Center, Children's Hospital of Fudan University, Shanghai, China. FAU - Wang, Feng AU - Wang F AD - Heart Center, Children's Hospital of Fudan University, Shanghai, China. FAU - Gui, Yonghao AU - Gui Y AD - National Health Commission Key Laboratory of Neonatal Diseases (Fudan University), Shanghai, China. AD - Institute of Pediatrics, Children's Hospital of Fudan University, Shanghai, China. AD - Heart Center, Children's Hospital of Fudan University, Shanghai, China. LA - eng PT - Journal Article DEP - 20251126 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC12683390 OTO - NOTNLM OT - Child OT - left ventricular hypertrophy (LVH) OT - nocturnal hypertension OT - primary hypertension OT - risk factor COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2025-567/coif). The authors have no conflicts of interest to declare. EDAT- 2025/12/10 06:28 MHDA- 2025/12/10 06:29 PMCR- 2025/11/30 CRDT- 2025/12/10 04:45 PHST- 2025/08/26 00:00 [received] PHST- 2025/10/22 00:00 [accepted] PHST- 2025/12/10 06:29 [medline] PHST- 2025/12/10 06:28 [pubmed] PHST- 2025/12/10 04:45 [entrez] PHST- 2025/11/30 00:00 [pmc-release] AID - tp-14-11-3011 [pii] AID - 10.21037/tp-2025-567 [doi] PST - ppublish SO - Transl Pediatr. 2025 Nov 30;14(11):3011-3019. doi: 10.21037/tp-2025-567. Epub 2025 Nov 26. PMID- 41367525 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251210 LR - 20251212 IS - 2224-4344 (Print) IS - 2224-4344 (Electronic) IS - 2224-4336 (Linking) VI - 14 IP - 11 DP - 2025 Nov 30 TI - Challenges and strategies in ICU nursing for pediatric patients post-craniopharyngioma surgery: a narrative review. PG - 3125-3138 LID - 10.21037/tp-2025-524 [doi] AB - BACKGROUND AND OBJECTIVE: Craniopharyngioma, a rare brain tumor in children, is primarily managed through surgical resection, but it carries a high risk of postoperative complications. These patients often require intensive care unit (ICU) monitoring and specialized nursing interventions. This narrative review aims to synthesize evidence on ICU nursing strategies for pediatric patients after craniopharyngioma surgery, focusing on monitoring, complication management, pain control, nutritional and psychological support, and multidisciplinary collaboration. METHODS: We conducted a narrative review of literature published from 2010 to 2024 using PubMed. Keywords included "children", "craniopharyngioma", "intensive care unit", "postoperative care", and "nursing challenges". Studies were selected based on predefined inclusion and exclusion criteria. Ethical approval was not required. KEY CONTENT AND FINDINGS: Analysis of included studies (total sample >1,200 pediatric cases across 12 studies) showed that visual function improvement was reported in up to 91% (range, 85-95%, n=342) of patients receiving structured postoperative monitoring. Diabetes insipidus (DI) occurred in approximately 36% (range, 30-45%, n=450) of cases, highlighting the need for vigilant electrolyte surveillance. Effective nursing interventions included early neurological assessment, strict input-output monitoring, multimodal pain management, enteral nutrition (EN) support, and family-centered psychological care. Multidisciplinary collaboration was consistently associated with reduced ICU length of stay and improved parent satisfaction. CONCLUSIONS: This review underscores the importance of individualized, evidence-based ICU nursing care in improving postoperative outcomes for pediatric craniopharyngioma patients. Despite observed benefits, large-scale randomized controlled trials (RCTs) are still needed to validate specific nursing protocols. CI - (c) AME Publishing Company. FAU - Wang, Juan AU - Wang J AD - Surgical Intensive Care Unit, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Zhu, Liqin AU - Zhu L AD - Surgical Intensive Care Unit, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Sheng, Meijun AU - Sheng M AUID- ORCID: 0000-0003-2867-451X AD - Surgical Intensive Care Unit, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. FAU - Bao, Yiyao AU - Bao Y AUID- ORCID: 0009-0003-2185-2122 AD - Surgical Intensive Care Unit, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China. LA - eng PT - Journal Article PT - Review DEP - 20251111 PL - China TA - Transl Pediatr JT - Translational pediatrics JID - 101649179 PMC - PMC12683377 OTO - NOTNLM OT - Children OT - craniopharyngioma OT - intensive care unit (ICU) OT - nursing challenges OT - postoperative care COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure form (available at https://tp.amegroups.com/article/view/10.21037/tp-2025-524/coif). The authors have no conflicts of interest to declare. EDAT- 2025/12/10 06:28 MHDA- 2025/12/10 06:29 PMCR- 2025/11/30 CRDT- 2025/12/10 04:45 PHST- 2025/08/05 00:00 [received] PHST- 2025/10/14 00:00 [accepted] PHST- 2025/12/10 06:29 [medline] PHST- 2025/12/10 06:28 [pubmed] PHST- 2025/12/10 04:45 [entrez] PHST- 2025/11/30 00:00 [pmc-release] AID - tp-14-11-3125 [pii] AID - 10.21037/tp-2025-524 [doi] PST - ppublish SO - Transl Pediatr. 2025 Nov 30;14(11):3125-3138. doi: 10.21037/tp-2025-524. Epub 2025 Nov 11. PMID- 41367255 OWN - NLM STAT- MEDLINE DCOM- 20251210 LR - 20260901 IS - 1460-2245 (Electronic) IS - 0957-4824 (Print) IS - 0957-4824 (Linking) VI - 40 IP - 6 DP - 2025 Oct 30 TI - Evaluating the Sustaining Play, Sustaining Health programme in Australian early childhood education and care services: a pilot randomized controlled trial. LID - 10.1093/heapro/daaf199 [doi] LID - daaf199 AB - Early childhood education and care (ECEC) services are a recommended setting to deliver interventions improving children's physical activity (PA). Indoor-outdoor free play, where children move freely between indoor-outdoor environments, can increase child PA. However, these programmes in ECECs are often not sustained. This study aims to assess the acceptability, feasibility, impact, adoption and cost of the Sustaining Play, Sustaining Health (SPSH) programme on sustainment of indoor-outdoor free play programmes in ECECs. A 6-month parallel-group pilot randomized controlled trial was conducted with 16 ECEC services across New South Wales, Australia, following removal of COronaVIrus Disease of 2019 (COVID-19) recommendations. Services implementing indoor-outdoor programmes were randomized to (i) SPSH programme (n = 8) or (ii) usual care control group (n = 8). The intervention included eight strategies to target identified barriers, informed by the Integrated Sustainability Framework. Primary outcomes at 6 months were acceptability, feasibility, adoption, cost, and barriers/facilitators. Potential impact (sustainment) was measured at 6 (primary) and 12 months using nonparametric analysis. Overall, 31.48% (17/54) of eligible services consented and 16 randomized. Statistically insignificant mean differences between groups in indoor-outdoor free play were 26.27 minutes at 6 months, and 2.87 minutes at 12 months, favouring the intervention group. The SPSH programme was considered acceptable and feasible and costed AUD $452.38 ($289.74 USD) to deliver per service. There were no changes in sustainability barriers/facilitators. This pilot found mean differences favouring the intervention group for sustaining indoor-outdoor free play programmes in ECECs, particularly at 12 months. Future fully powered trials should consider addressing broader barriers including staff turnover, motivation/attitudes, and fit within broader contexts to increase impact. CI - (c) The Author(s) 2025. Published by Oxford University Press. FAU - Imad, Noor AU - Imad N AUID- ORCID: 0000-0002-0625-2407 AD - School of Health Sciences, Department of Allied Health, Swinburne University of Technology, PO Box 218, Hawthorn, VIC 3122, Australia. AD - Hunter New England Population Health, Hunter New England Local Health District, Locked Bag 10, Wallsend, NSW 2287, Australia. AD - Global Centre for Preventive Health and Nutrition, Institute for Health Transformation, School of Health and Social Development, Faculty of Health, Deakin University, 1 Gheringhap Street, Geelong, VIC 3220, Australia. FAU - Hall, Alix AU - Hall A AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia. AD - Population Health Research Program, Hunter Medical Research Institute, PO Box 1000, New Lambton Heights, NSW 2305, Australia. AD - Sydney Local Health District, Population Health, Sydney, PO Box 385, Parramatta, NSW 2124, Australia. FAU - Giles, Luke AU - Giles L AD - Hunter New England Population Health, Hunter New England Local Health District, Locked Bag 10, Wallsend, NSW 2287, Australia. FAU - Pearson, Nicole AU - Pearson N AD - Hunter New England Population Health, Hunter New England Local Health District, Locked Bag 10, Wallsend, NSW 2287, Australia. AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia. AD - Population Health Research Program, Hunter Medical Research Institute, PO Box 1000, New Lambton Heights, NSW 2305, Australia. AD - Sydney Local Health District, Population Health, Sydney, PO Box 385, Parramatta, NSW 2124, Australia. FAU - Shoesmith, Adam AU - Shoesmith A AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia. AD - Population Health Research Program, Hunter Medical Research Institute, PO Box 1000, New Lambton Heights, NSW 2305, Australia. AD - Sydney Local Health District, Population Health, Sydney, PO Box 385, Parramatta, NSW 2124, Australia. FAU - Nathan, Nicole AU - Nathan N AD - Hunter New England Population Health, Hunter New England Local Health District, Locked Bag 10, Wallsend, NSW 2287, Australia. AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia. AD - Population Health Research Program, Hunter Medical Research Institute, PO Box 1000, New Lambton Heights, NSW 2305, Australia. AD - Sydney Local Health District, Population Health, Sydney, PO Box 385, Parramatta, NSW 2124, Australia. FAU - Grady, Alice AU - Grady A AUID- ORCID: 0000-0003-3379-5340 AD - Hunter New England Population Health, Hunter New England Local Health District, Locked Bag 10, Wallsend, NSW 2287, Australia. AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia. AD - Population Health Research Program, Hunter Medical Research Institute, PO Box 1000, New Lambton Heights, NSW 2305, Australia. AD - Sydney Local Health District, Population Health, Sydney, PO Box 385, Parramatta, NSW 2124, Australia. FAU - Renda, Ana AU - Renda A AUID- ORCID: 0000-0003-4319-2447 AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia. AD - Sydney Local Health District, Population Health, Sydney, PO Box 385, Parramatta, NSW 2124, Australia. FAU - Belski, Regina AU - Belski R AD - Sport, Performance and Nutrition Research Group, Department of Sport, Exercise and Nutrition Sciences, La Trobe University, Sports Drive, Bundoora, VIC 3086, Australia. FAU - Yoong, Serene AU - Yoong S AD - Global Centre for Preventive Health and Nutrition, Institute for Health Transformation, School of Health and Social Development, Faculty of Health, Deakin University, 1 Gheringhap Street, Geelong, VIC 3220, Australia. AD - School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of Newcastle, University Drive, Callaghan, NSW 2308, Australia. AD - Population Health Research Program, Hunter Medical Research Institute, PO Box 1000, New Lambton Heights, NSW 2305, Australia. AD - Sydney Local Health District, Population Health, Sydney, PO Box 385, Parramatta, NSW 2124, Australia. LA - eng GR - APP1170042/National Health and Medical Research Council/ GR - 106654/WT_/Wellcome Trust/United Kingdom GR - Deakin University/ GR - 102518/Heart Foundation/ GR - GS2000053/NHMRC MRFF/ GR - Hunter New England Population Health/ PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Health Promot Int JT - Health promotion international JID - 9008939 SB - IM MH - Humans MH - Pilot Projects MH - Child, Preschool MH - Male MH - *Health Promotion/methods/organization & administration MH - Female MH - *Exercise MH - *Play and Playthings MH - COVID-19 MH - New South Wales MH - Program Evaluation MH - Australia PMC - PMC12681264 OTO - NOTNLM OT - acceptability OT - early childhood education and care OT - feasibility OT - outdoor free play OT - physical activity OT - pilot randomized controlled trial OT - sustainment COIS- The authors declare that they have no conflicts of interest. EDAT- 2025/12/10 06:28 MHDA- 2025/12/10 06:29 PMCR- 2025/12/06 CRDT- 2025/12/10 03:46 PHST- 2025/12/10 06:29 [medline] PHST- 2025/12/10 06:28 [pubmed] PHST- 2025/12/10 03:46 [entrez] PHST- 2025/12/06 00:00 [pmc-release] AID - 8372359 [pii] AID - daaf199 [pii] AID - 10.1093/heapro/daaf199 [doi] PST - ppublish SO - Health Promot Int. 2025 Oct 30;40(6):daaf199. doi: 10.1093/heapro/daaf199. PMID- 41367220 OWN - NLM STAT- MEDLINE DCOM- 20251210 LR - 20260825 IS - 2047-6310 (Electronic) IS - 2047-6302 (Print) IS - 2047-6302 (Linking) VI - 21 IP - 1 DP - 2026 Jan TI - Components of Adolescent Behavioural Interventions With Eating Disorder Outcomes: Systematic Review With Intervention Mapping. PG - e70074 LID - 10.1111/ijpo.70074 [doi] LID - e70074 AB - OBJECTIVE: To understand delivery features and intervention strategies of adolescent weight management interventions which may influence eating disorder risk. METHODS: Systematic searches in four databases and two trial registries to identify randomised controlled trials in adolescents with overweight/obesity measuring eating disorder risk pre- and post-intervention. Delivery features and intervention strategies were coded from published descriptions using a project-specific codebook, validated by trial investigators and narratively synthesised. RESULTS: Of 11 860 records screened, 23 trials, with 54 intervention arms, were included in the analysis. Most interventions focused on weight loss and maintenance (54%) and were informed by a cognitive behavioural framework (43%). Interventions commonly targeted an individual with a support person (70%). Median intervention duration was 26 weeks, with weekly (35%) or staged (e.g., weekly, then monthly) visit (41%) frequency. Interventions had a mean (SD) of 30 (16.1) intervention strategies. Most included healthy eating education (89%), physical activity education (89%) and problem-solving barriers to dietary change (80%). Few included mental health strategies (17%). Interventions included 'dietary prescription' (65%), and 78% promoted 'healthful/helpful eating behaviours'. CONCLUSION: Weight management interventions are complex and vary in delivery approach and strategies used to change behaviors. Characterising interventions is a critical first step to understanding how weight management interventions' influence eating disorder risk. CI - (c) 2025 The Author(s). Pediatric Obesity published by John Wiley & Sons Ltd on behalf of World Obesity Federation. FAU - Lister, Natalie B AU - Lister NB AUID- ORCID: 0000-0002-9148-8632 AD - Children's Hospital Westmead Clinical School, The University of Sydney, Westmead, New South Wales, Australia. AD - Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, Australia. FAU - Khalid, Rabia AU - Khalid R AUID- ORCID: 0000-0002-2653-5834 AD - Children's Hospital Westmead Clinical School, The University of Sydney, Westmead, New South Wales, Australia. AD - Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, Australia. FAU - Jardine, Isabelle R AU - Jardine IR AUID- ORCID: 0009-0009-6651-5246 AD - Children's Hospital Westmead Clinical School, The University of Sydney, Westmead, New South Wales, Australia. FAU - Pryde, Samantha AU - Pryde S AD - College of Nursing and Health Sciences, Caring Futures Institute, Flinders University, Adelaide, South Australia, Australia. FAU - Melville, Hannah AU - Melville H AUID- ORCID: 0000-0002-0037-0437 AD - Children's Hospital Westmead Clinical School, The University of Sydney, Westmead, New South Wales, Australia. AD - Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, Australia. FAU - Seidler, Anna L AU - Seidler AL AUID- ORCID: 0000-0002-0027-1623 AD - National Health and Medical Research Council Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia. AD - Department of Child and Adolescent Psychiatry, University Medical Centre Rostock, Rostock, Germany. AD - German Center for Child and Adolescent Health (DZKJ), Partner Site Greifswald/Rostock, Rostock, Germany. FAU - Hunter, Kylie E AU - Hunter KE AUID- ORCID: 0000-0002-2796-9220 AD - National Health and Medical Research Council Clinical Trials Centre, The University of Sydney, Sydney, New South Wales, Australia. FAU - Ahern, Amy L AU - Ahern AL AUID- ORCID: 0000-0001-5069-4758 AD - MRC Epidemiology Unit, University of Cambridge, Cambridge, Cambridgeshire, UK. FAU - Baur, Louise A AU - Baur LA AUID- ORCID: 0000-0002-4521-9482 AD - Children's Hospital Westmead Clinical School, The University of Sydney, Westmead, New South Wales, Australia. AD - Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, Australia. AD - The Children's Hospital at Westmead, Weight Management Services, Westmead, New South Wales, Australia. FAU - Braet, Caroline AU - Braet C AUID- ORCID: 0000-0003-2458-287X AD - Department of Developmental, Personality and Social Psychology, Ghent University, Ghent, Belgium. FAU - Garnett, Sarah P AU - Garnett SP AUID- ORCID: 0000-0001-7552-0789 AD - Children's Hospital Westmead Clinical School, The University of Sydney, Westmead, New South Wales, Australia. AD - The Children's Hospital at Westmead, Kids Research, Westmead, New South Wales, Australia. FAU - Hill, Andrew J AU - Hill AJ AUID- ORCID: 0000-0003-3192-0427 AD - School of Medicine, University of Leeds, Leeds, UK. FAU - Maguire, Sarah AU - Maguire S AUID- ORCID: 0000-0003-0754-9189 AD - Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, Australia. AD - InsideOut Institute for Eating Disorders, The University of Sydney, Camperdown, New South Wales, Australia. FAU - Nicholls, Dasha AU - Nicholls D AUID- ORCID: 0000-0001-7257-6605 AD - Imperial College London, Division of Psychiatry, National Institute for Health Research, Applied Research Collaboration, London, UK. FAU - Paxton, Susan J AU - Paxton SJ AD - School of Psychology and Public Health, La Trobe University, Melbourne, Victoria, Australia. FAU - Piya, Milan K AU - Piya MK AUID- ORCID: 0000-0002-2783-1168 AD - School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia. AD - Campbelltown and Camden Hospitals, Campbelltown, New South Wales, Australia. FAU - Sainsbury, Amanda AU - Sainsbury A AUID- ORCID: 0000-0001-9176-1574 AD - School of Human Sciences, The University of Western Australia, Crawley, Western Australia, Australia. FAU - Steinbeck, Katharine AU - Steinbeck K AUID- ORCID: 0000-0003-1099-0522 AD - Children's Hospital Westmead Clinical School, The University of Sydney, Westmead, New South Wales, Australia. FAU - Wilfley, Denise E AU - Wilfley DE AUID- ORCID: 0000-0002-3599-8689 AD - School of Medicine, Washington University in St. Louis, St Louis, Missouri, USA. FAU - Cooper, Kelly AU - Cooper K AUID- ORCID: 0000-0001-9259-3162 AD - The Weight Issues Network, Sydney, New South Wales, Australia. FAU - Dammery, Genevieve AU - Dammery G AD - Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, Australia. AD - InsideOut Institute for Eating Disorders, The University of Sydney, Camperdown, New South Wales, Australia. FAU - Grunseit, Alicia M AU - Grunseit AM AD - The Children's Hospital at Westmead, Weight Management Services, Westmead, New South Wales, Australia. FAU - Heeren, Faith Anne N AU - Heeren FAN AUID- ORCID: 0000-0002-6819-8258 AD - Department of Health Outcomes and Biomedical Informatics, University of Florida College of Medicine, Gainesville, Florida, USA. FAU - Jones, Rebecca A AU - Jones RA AUID- ORCID: 0000-0003-2197-1175 AD - MRC Epidemiology Unit, University of Cambridge, Cambridge, Cambridgeshire, UK. AD - WeightWatchers International, Inc., New York, New York, USA. FAU - Kyle, Theodore K AU - Kyle TK AD - ConscienHealth, Pittsburgh, Pennsylvania, USA. FAU - Quigley, Fiona AU - Quigley F AD - Institute of Nursing and Health Research, Ulster University, Newtownabbey, Co. Antrim, UK. FAU - Robbins, Molly AU - Robbins M AUID- ORCID: 0009-0005-5624-3954 AD - College of Psychology, Nova Southeastern University, Davie, Florida, USA. FAU - Yourell, Jacqlyn AU - Yourell J AUID- ORCID: 0000-0003-2958-1411 AD - Fit Minded Inc., Phoenix, Arizona, USA. FAU - Bean, Melanie K AU - Bean MK AUID- ORCID: 0000-0002-8695-8054 AD - Department of Pediatrics, School of Medicine, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, Virginia, USA. FAU - Bonham, Maxine P AU - Bonham MP AUID- ORCID: 0000-0002-4854-1581 AD - Department of Nutrition, Dietetics & Food, Faculty of Medicine, Nursing & Health Sciences, Monash University, Notting Hill, Victoria, Australia. FAU - Boutelle, Kerri N AU - Boutelle KN AD - Department of Pediatrics, University of California San Diego, San Diego, California, USA. FAU - Cardel, Michelle I AU - Cardel MI AD - Department of Health Outcomes and Biomedical Informatics, University of Florida College of Medicine, Gainesville, Florida, USA. AD - WeightWatchers International, Inc., New York, New York, USA. FAU - Darling, Katherine E AU - Darling KE AUID- ORCID: 0000-0002-1858-4644 AD - Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, USA. AD - Weight Control and Diabetes Research Center, The Miriam Hospital, Providence, Rhode Island, USA. FAU - Dordevic, Aimee L AU - Dordevic AL AUID- ORCID: 0000-0002-0405-3164 AD - Department of Nutrition, Dietetics & Food, Faculty of Medicine, Nursing & Health Sciences, Monash University, Notting Hill, Victoria, Australia. FAU - Eichen, Dawn M AU - Eichen DM AD - Department of Pediatrics, University of California San Diego, San Diego, California, USA. FAU - Epstein, Leonard H AU - Epstein LH AUID- ORCID: 0000-0003-1167-8848 AD - Department of Pediatrics, Jacobs School of Medicine, and Biomedical Sciences, University at Buffalo, Buffalo, New York, USA. FAU - Goldschmidt, Andrea B AU - Goldschmidt AB AUID- ORCID: 0000-0003-1620-8300 AD - Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. FAU - Jelalian, Elissa AU - Jelalian E AUID- ORCID: 0000-0003-0933-4464 AD - Department of Psychiatry and Human Behavior, Alpert Medical School of Brown University, Providence, Rhode Island, USA. AD - Weight Control and Diabetes Research Center, The Miriam Hospital, Providence, Rhode Island, USA. FAU - Lofrano-Prado, Mara Cristina AU - Lofrano-Prado MC AD - Department of Psychology & Kinesiology, California State University, San Bernardino, California, USA. FAU - Naets, Tiffany AU - Naets T AUID- ORCID: 0000-0002-9560-5613 AD - Department of Developmental, Personality and Social Psychology, Ghent University, Ghent, Belgium. AD - Department of Health Care, Odisee University of Applied Sciences, Nutrition and Dietetics, Ghent, Belgium. FAU - Prado, Wagner L AU - Prado WL AUID- ORCID: 0000-0002-8296-3024 AD - Department of Kinesiology, California State University, San Bernardino, California, USA. FAU - Skjakodegard, Hanna F AU - Skjakodegard HF AUID- ORCID: 0000-0002-6340-7348 AD - Children and Youth Clinic, Haukeland University Hospital, Bergen, Vestland, Norway. AD - Counseling on Eating Disorders, ROS, Bergen, Vestland, Norway. FAU - Danielsen, Yngvild Sorebo AU - Danielsen YS AUID- ORCID: 0000-0002-4117-8900 AD - Department of Clinical Psychology, University of Bergen, Bergen, Vestland, Norway. AD - Regional Department of Eating Disorders, Haukeland University Hospital, Bergen, Vestland, Norway. FAU - Stein, Richard I AU - Stein RI AD - School of Medicine, Washington University in St. Louis, St Louis, Missouri, USA. FAU - Tanofsky-Kraff, Marian AU - Tanofsky-Kraff M AD - Department of Medical and Clinical Psychology, School of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA. AD - Section on Growth and Obesity, Division of Intramural Research, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA. FAU - Van Eyck, Annelies AU - Van Eyck A AUID- ORCID: 0000-0003-4722-969X AD - Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Antwerp, Belgium. AD - Department of Pediatrics, Antwerp University Hospital, Antwerp, Belgium. FAU - Vidmar, Alaina P AU - Vidmar AP AUID- ORCID: 0000-0003-3790-6255 AD - Children's Hospital Los Angeles and Keck School of Medicine, Department of Pediatrics, University of Southern California, California, Los Angeles, USA. AD - Center for Endocrinology, Diabetes and Metabolism, California, Los Angeles, USA. FAU - Yanovski, Jack A AU - Yanovski JA AUID- ORCID: 0000-0001-8542-1637 AD - Section on Growth and Obesity, Division of Intramural Research, National Institutes of Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA. FAU - Johnson, Brittany J AU - Johnson BJ AUID- ORCID: 0000-0001-5492-9219 AD - College of Nursing and Health Sciences, Caring Futures Institute, Flinders University, Adelaide, South Australia, Australia. FAU - Jebeile, Hiba AU - Jebeile H AUID- ORCID: 0000-0002-8623-6174 AD - Children's Hospital Westmead Clinical School, The University of Sydney, Westmead, New South Wales, Australia. AD - Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, Australia. CN - EDIT Collaboration LA - eng GR - 2002310/National Health and Medical Research Council/ GR - 2009035/National Health and Medical Research Council/ PT - Journal Article PT - Systematic Review PL - England TA - Pediatr Obes JT - Pediatric obesity JID - 101572033 SB - IM MH - Humans MH - *Feeding and Eating Disorders/therapy/psychology/prevention & control MH - Adolescent MH - *Pediatric Obesity/therapy/psychology MH - *Behavior Therapy/methods MH - *Adolescent Behavior/psychology MH - Treatment Outcome MH - Randomized Controlled Trials as Topic MH - Weight Loss PMC - PMC12690354 OTO - NOTNLM OT - behaviour change techniques OT - disordered eating OT - obesity OT - obesity treatment OT - overweight COIS- N.B.L., R.K., I.R.J., S.P., H.M., A.L.S, K.E.H., C.B., S.P.G., S.M., D.N., S.J.P., K.S., K.C., G.D., A.M.G., F.Q., M.R., J.Y., M.K.B., M.P.B., K.N.B., K.E.D., D.M.E., L.H.E., A.B.G., E.J., M.C.L.-P., T.N., W.L.P., R.I.S., M.T.-K., A.V.E., B.J.J., H.J. declare no conflicts of interest. A.L.A. is on the Scientific Advisory Board for WW and chairs a Trial Steering Committee for Menwell Ltd. L.A.B. is immediate Past-President (2022-2024) of the World Obesity Federation, an honorary, unpaid position. She has received honoraria for speaking in forums organised by Novo Nordisk (NN) in relation to management of adolescent obesity (funds directed to research cost centre). L.A.B. is the Australian lead of the study-ACTION Teens: sponsored by NN (multi-country on-line study of attitudes towards and perceptions of obesity held by adolescents living with obesity, their parents and health care professionals). L.A.B. has received honoraria (funds directed to hospital research cost centre) for being a member of the Lilly Weight Management Advisory Board. A.J.H. has received payment for advice given to Slimming World (UK). M.K.P. has received travel and consulting fees for speaking and advisory boards from Novo Nordisk, Eli Lilly, Johnson and Johnson Medical Pty Ltd, Takeda Pharmaceuticals and iNova Pharmaceuticals. He was on the guideline development committee for the National Eating Disorder Collaboration 'Management of eating disorders for people with higher weight: clinical practice guideline (2022)' and is Vice President of the Australia and New Zealand Obesity Society (ANZOS). A.S. owns 50% of the shares in Zuman International Pty Ltd, which receives royalties and other payments for educational resources and services in adult weight management and research methodology. F.A.N.H. reports serving on the Obesity Society's Finance Committee, consulting fees from WW, an honorarium for speaking from the American Academy of Pediatrics, institutional support to travel and membership on the Obesity Action Coalition's Membership and Access to Care Committees, outside the scope of the submitted work. R.A.J. is an employee and shareholder of WeightWatchers International (WW). T.K.K. has received professional fees from Novo Nordisk, Nutrisystem, Emerald Lake Safety, Roman Health Ventures and Boehringer Ingelheim. M.I.C. is an employee and shareholder of WW International Inc. A.L.D. has an honorary, unpaid position at Nutrition Society of Australia as Honorary Secretary and Director of the Board from 2024. H.F.S. previously received salary from Novo Nordisk unrelated to the present work. Y.S.D. received a one-time payment from NovoNordisk for creating information materials about eating disorders for health care professionals. Y.S.D. is part of the steering group of the E-BATTLE Obesity trial a placebo-controlled RCT testing semaglutide in the treatment of severe obesity in adolescents (starting in 2025). Medications and placebo-medications are provided by Novo Nordisk but not funding for the study. A.P.V. has received consulting fees from Rhythm Pharmaceuticals and Soleno Pharmaceuticals. J.A.Y. reports unrelated grant funds to NICHD supporting his clinical research from Soleno Therapeutics, Rhythm Pharmaceuticals and Hikma Pharmaceuticals and materials from Versanis Bio to support mouse studies. FIR - Lister, Natalie B IR - Lister NB FIR - Jebeile, Hiba IR - Jebeile H FIR - Seidler, Anna L IR - Seidler AL FIR - Johnson, Brittany J IR - Johnson BJ FIR - Khalid, Rabia IR - Khalid R FIR - Melville, Hannah IR - Melville H FIR - Libesman, Sol IR - Libesman S FIR - Tredinnick, Ruth IR - Tredinnick R FIR - Pryde, Samantha IR - Pryde S FIR - McMaster, Caitlin M IR - McMaster CM FIR - Hunter, Kylie E IR - Hunter KE FIR - Jardine, Isabelle R IR - Jardine IR FIR - Lorien, Sasha J IR - Lorien SJ FIR - Ahern, Amy L IR - Ahern AL FIR - Askie, Lisa IR - Askie L FIR - Baur, Louise A IR - Baur LA FIR - Braet, Caroline IR - Braet C FIR - Cooper, Kelly IR - Cooper K FIR - Dammery, Genevieve IR - Dammery G FIR - Garnett, Sarah P IR - Garnett SP FIR - Golley, Rebecca IR - Golley R FIR - Grunseit, Alicia M IR - Grunseit AM FIR - Heeren, Faith Anne N IR - Heeren FAN FIR - Hill, Andrew J IR - Hill AJ FIR - Jones, Rebecca A IR - Jones RA FIR - Kyle, Theodore K IR - Kyle TK FIR - Maguire, Sarah IR - Maguire S FIR - Nicholls, Dasha IR - Nicholls D FIR - Paxton, Susan J IR - Paxton SJ FIR - Piya, Milan K IR - Piya MK FIR - Quigley, Fiona IR - Quigley F FIR - Robbins, Molly IR - Robbins M FIR - Sainsbury, Amanda IR - Sainsbury A FIR - Steinbeck, Katharine IR - Steinbeck K FIR - Wilfley, Denise E IR - Wilfley DE FIR - Yourell, Jacqlyn IR - Yourell J FIR - Barnes, Rachel D IR - Barnes RD FIR - Bean, Melanie K IR - Bean MK FIR - Beaulieu, Kristine IR - Beaulieu K FIR - Bonham, Maxine P IR - Bonham MP FIR - Boutelle, Kerri N IR - Boutelle KN FIR - Braet, Caroline IR - Braet C FIR - Branco, Braulio IR - Branco B FIR - Calugi, Simona IR - Calugi S FIR - Cardel, Michelle I IR - Cardel MI FIR - Carpenter, Kelly M IR - Carpenter KM FIR - Cheng, Hoi Lun IR - Cheng HL FIR - Dalle Grave, Riccardo IR - Dalle Grave R FIR - Darling, Katherine E IR - Darling KE FIR - Davy, Brenda IR - Davy B FIR - Demarzo, Marcelo IR - Demarzo M FIR - Dordevic, Aimee L IR - Dordevic AL FIR - Eichen, Dawn M IR - Eichen DM FIR - Epstein, Leonard H IR - Epstein LH FIR - Goldschmidt, Andrea B IR - Goldschmidt AB FIR - Gross, Amy IR - Gross A FIR - Heeren, Faith Anne N IR - Heeren FAN FIR - Hilbert, Anja IR - Hilbert A FIR - Houben, Katrijn IR - Houben K FIR - Howes, Erica M IR - Howes EM FIR - Jelalian, Elissa IR - Jelalian E FIR - Lister, Natalie B IR - Lister NB FIR - Lofrano-Prado, Mara Cristina IR - Lofrano-Prado MC FIR - Martin, Corby IR - Martin C FIR - McTiernan, Anne IR - McTiernan A FIR - Mensinger, Janell IR - Mensinger J FIR - Naets, Tiffany IR - Naets T FIR - Nicholls, Dasha IR - Nicholls D FIR - Pacanowski, Carly IR - Pacanowski C FIR - Partridge, Stephanie IR - Partridge S FIR - Prado, Wagner L IR - Prado WL FIR - Ramalho, Sofia Marques IR - Ramalho SM FIR - Raman, Jaythani IR - Raman J FIR - Raynor, Hollie A IR - Raynor HA FIR - Rhee, Kyung E IR - Rhee KE FIR - Rieger, Elizabeth IR - Rieger E FIR - Robinson, Eric IR - Robinson E FIR - Sainsbury, Amanda IR - Sainsbury A FIR - Salvo, Vera IR - Salvo V FIR - Shelley, Brian M IR - Shelley BM FIR - Sherwood, Nancy E IR - Sherwood NE FIR - Simpson, Sharon A IR - Simpson SA FIR - Skjakodegard, Hanna F IR - Skjakodegard HF FIR - Smith, Evelyn IR - Smith E FIR - Danielsen, Yngvild Sorebo IR - Danielsen YS FIR - Stein, Richard I IR - Stein RI FIR - Tanofsky-Kraff, Marian IR - Tanofsky-Kraff M FIR - Taylor, Rachael W IR - Taylor RW FIR - Van Eyck, Annelies IR - Van Eyck A FIR - Varady, Krista A IR - Varady KA FIR - Vidmar, Alaina P IR - Vidmar AP FIR - Whitelock, Victoria IR - Whitelock V FIR - Wilfley, Denise E IR - Wilfley DE FIR - Yanovski, Jack A IR - Yanovski JA EDAT- 2025/12/10 06:28 MHDA- 2025/12/10 06:29 PMCR- 2025/12/10 CRDT- 2025/12/10 03:33 PHST- 2025/10/15 00:00 [revised] PHST- 2025/04/30 00:00 [received] PHST- 2025/11/05 00:00 [accepted] PHST- 2025/12/10 06:29 [medline] PHST- 2025/12/10 06:28 [pubmed] PHST- 2025/12/10 03:33 [entrez] PHST- 2025/12/10 00:00 [pmc-release] AID - IJPO70074 [pii] AID - 10.1111/ijpo.70074 [doi] PST - ppublish SO - Pediatr Obes. 2026 Jan;21(1):e70074. doi: 10.1111/ijpo.70074. PMID- 41366383 OWN - NLM STAT- MEDLINE DCOM- 20251209 LR - 20251212 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 25 IP - 1 DP - 2025 Dec 9 TI - Nonlinear association between physical fitness and sports injury risk among Chinese high school students: a cross-sectional study. PG - 4237 LID - 10.1186/s12889-025-25280-w [doi] LID - 4237 AB - BACKGROUND: Sports injuries are a prevalent public health issue among adolescents, yet the association between physical fitness and injury risk in Chinese high school students remains under-investigated. This study aimed to evaluate the relationship between physical fitness levels and the risk of sports-related injuries among high school students in China. METHODS: A cross-sectional study was conducted among 1,659 students aged 15-18 years from six high schools in Shanghai. Physical fitness was assessed using standardized national tests (e.g., sprint, endurance run, standing long jump, sit-and-reach, strength measures). Sports injury data were collected via validated questionnaires. Students were categorized into quartiles based on composite fitness scores. Multivariate logistic regression models were used to estimate adjusted odds ratios (ORs) and 95% confidence intervals (CIs) for injury risk across fitness levels. A two-piecewise linear regression was applied to explore potential non-linear associations. RESULTS: The overall injury prevalence was 23.0%, higher in boys (26.7%) than girls (19.2%). Compared to the lowest fitness quartile, students in the highest quartile had a significantly lower injury risk (adjusted OR = 0.13, 95% CI: 0.08-0.17). A clear dose-response relationship was observed (P for trend < 0.001). Below a composite fitness score of 65, each 1-point increase was associated with a 14% reduction in injury odds (OR = 0.86, 95% CI: 0.83-0.89); above this threshold, the association was no longer significant. CONCLUSIONS: Physical fitness was inversely associated with sports injury risk among Chinese high school students. A threshold effect was identified at a fitness score of 65, below which injury risk declined sharply with each point increase. Interventions should prioritize students below this cutoff to effectively reduce injury incidence. CI - (c) 2025. The Author(s). FAU - Zhang, Qiangjin AU - Zhang Q AD - Physical Education Teaching and Research Group, Shanghai Qunxing Vocational--Technical School, 240 Dezhou Road, Pudong New Area, Shanghai, 200126, China. FAU - Zhang, Sui AU - Zhang S AD - Physical Education Teaching and Research Group, Shanghai Qunxing Vocational--Technical School, 240 Dezhou Road, Pudong New Area, Shanghai, 200126, China. FAU - Zhang, Shaolong AU - Zhang S AD - Physical Education Teaching and Research Group, Shanghai Qunxing Vocational--Technical School, 240 Dezhou Road, Pudong New Area, Shanghai, 200126, China. FAU - Zhang, Lin AU - Zhang L AD - West China Hospital Sichuan University Jintang Hospital, Jintang First People's Hospital, No. 886 Jinguang Road, Jintang County, Chengdu, Sichuan, 610400, China. zl17361067432@163.com. LA - eng PT - Journal Article DEP - 20251209 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - Chinese people SB - IM MH - Humans MH - Male MH - Female MH - Cross-Sectional Studies MH - Adolescent MH - China/epidemiology MH - *Physical Fitness MH - *Athletic Injuries/epidemiology MH - *Students/statistics & numerical data MH - Risk Factors MH - Schools MH - Prevalence MH - Surveys and Questionnaires MH - East Asian People PMC - PMC12690912 OTO - NOTNLM OT - Cross-sectional study OT - High school students OT - Injury prevention OT - Physical fitness OT - Sports injury COIS- Declarations. Ethics approval and consent to participate: The study was approved by Ethics Committee of Shanghai Qunxing Vocational and Technical School (No. #202004065). All methods were carried out in accordance with relevant guidelines and regulations. This study was carried out in compliance with the Declaration of Helsinki, the Ethical approvals are detailed in the Supplementary. Parents/guardians of the students participating in the study were provided with informed consent forms, and their consent was obtained for their children's participation. Prior to their participation, all students were informed in a manner consistent with the information provided to their parents/guardians, and their individual consent was also obtained. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/10 01:47 MHDA- 2025/12/10 01:48 PMCR- 2025/12/09 CRDT- 2025/12/09 23:41 PHST- 2025/07/31 00:00 [received] PHST- 2025/10/13 00:00 [accepted] PHST- 2025/12/10 01:48 [medline] PHST- 2025/12/10 01:47 [pubmed] PHST- 2025/12/09 23:41 [entrez] PHST- 2025/12/09 00:00 [pmc-release] AID - 10.1186/s12889-025-25280-w [pii] AID - 25280 [pii] AID - 10.1186/s12889-025-25280-w [doi] PST - epublish SO - BMC Public Health. 2025 Dec 9;25(1):4237. doi: 10.1186/s12889-025-25280-w. PMID- 41366255 OWN - NLM STAT- MEDLINE DCOM- 20260103 LR - 20260106 IS - 2052-4463 (Electronic) IS - 2052-4463 (Linking) VI - 13 IP - 1 DP - 2025 Dec 9 TI - The COMPWALK-ACL: A Dataset of Multi-pace IMU Gait Kinematics in Adolescents, Adults, and ACL Injured Patients. PG - 4 LID - 10.1038/s41597-025-06307-8 [doi] LID - 4 AB - Gait analysis provides objective, quantitative parameters essential for assessing mobility, identifying movement impairments, and monitoring the progress of rehabilitation. While traditional lab-based systems offer high accuracy, wearable Inertial Measurement Units (IMUs) enable portable, cost-effective gait assessments outside the laboratory environment. However, the reliability and applicability of IMU-derived data across diverse populations and walking conditions require robust datasets. This paper presents a lower limb kinematic dataset acquired with the Xsens Awinda IMU system. Data were collected from 92 unique participants: healthy adults (n = 25), healthy adolescents (n = 27), and individuals with ACL injuries assessed before surgery (n = 40), with 27 completing a follow-up three months post-reconstruction. Participants walked overground at self-selected slow, normal, and fast speeds. The dataset contains spatiotemporal parameters, as well as lower limb joint kinematics. It enables research on normative gait across age groups, the effects of ACL injury and early recovery on movement patterns, and the development of IMU-based gait analysis methods under different walking speeds and clinical conditions. CI - (c) 2025. The Author(s). FAU - Yona, Tomer AU - Yona T AD - Department of Biomedical Engineering, Technion, Israel Institute of Technology, Haifa, Israel. FAU - Peskin, Bezalel AU - Peskin B AD - Orthopedic Department, Rambam Health Care Campus, Haifa, Israel. FAU - Fischer, Arielle AU - Fischer A AUID- ORCID: 0000-0003-4493-5222 AD - Department of Biomedical Engineering, Technion, Israel Institute of Technology, Haifa, Israel. ariellef@technion.ac.il. LA - eng GR - 2070658/Israel Science Foundation (ISF)/ PT - Dataset PT - Journal Article DEP - 20251209 PL - England TA - Sci Data JT - Scientific data JID - 101640192 SB - IM MH - Humans MH - Biomechanical Phenomena MH - Adolescent MH - Adult MH - *Gait MH - *Anterior Cruciate Ligament Injuries/physiopathology MH - Male MH - Female MH - Young Adult MH - Gait Analysis MH - Wearable Electronic Devices MH - Walking PMC - PMC12764956 COIS- Competing interests: The authors declare no competing interests. EDAT- 2025/12/10 01:47 MHDA- 2026/01/04 00:32 PMCR- 2025/12/09 CRDT- 2025/12/09 23:35 PHST- 2025/06/23 00:00 [received] PHST- 2025/11/11 00:00 [accepted] PHST- 2026/01/04 00:32 [medline] PHST- 2025/12/10 01:47 [pubmed] PHST- 2025/12/09 23:35 [entrez] PHST- 2025/12/09 00:00 [pmc-release] AID - 10.1038/s41597-025-06307-8 [pii] AID - 6307 [pii] AID - 10.1038/s41597-025-06307-8 [doi] PST - epublish SO - Sci Data. 2025 Dec 9;13(1):4. doi: 10.1038/s41597-025-06307-8. PMID- 41366037 OWN - NLM STAT- MEDLINE DCOM- 20260114 LR - 20260117 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2025 Dec 9 TI - Network pharmacology identifies AKR1C3 and KYNU as potential targets of Astragalus Membranaceus and Ephedra in pediatric obesity-associated asthma. PG - 1817 LID - 10.1038/s41598-025-31533-w [doi] LID - 1817 AB - This study aimed to identify and validate key target genes of Astragalus membranaceus and Ephedra in pediatric obesity-associated asthma using integrated bioinformatics and network pharmacology approaches, with the goal of informing potential therapeutic strategies. Gene expression datasets related to pediatric obesity (GSE205668, GSE104815) and asthma (GSE147878, GSE143303) were analyzed. Candidate genes were obtained by overlapping differentially expressed genes with known targets of Astragalus membranaceus and Ephedra. Machine learning algorithms and expression analyses were applied to refine the list of key genes. Two nomogram prediction models were constructed based on these genes and assessed for diagnostic efficacy. Subsequent analyses included functional enrichment, immune cell infiltration profiling, molecular docking, and validation through reverse transcription quantitative PCR (RT-qPCR). The genes AKR1C3 and KYNU were identified as key targets associated with both pediatric obesity and asthma. RT-qPCR results demonstrated significantly elevated expression of AKR1C3 and KYNU in samples from individuals with obesity-related asthma (P < 0.01). The developed nomogram models accurately predicted disease risk. Functional enrichment analysis indicated that these genes were co-enriched in pathways including allograft rejection in the context of obesity and primary immunodeficiency in the context of asthma. Immune cell profiling indicated alterations in 18 immune cell types in pediatric obesity and 5 in asthma. Molecular docking results indicated that kaempferol and apigenin exhibited strong binding affinities with AKR1C3, while canavanine effectively targeted KYNU, with a binding energy of - 9.5 kcal/mol between AKR1C3 and kaempferol. AKR1C3 and KYNU were identified and experimentally validated as potential therapeutic targets in pediatric asthma associated with obesity. These findings support the therapeutic relevance of A. membranaceus and Ephedra-derived compounds in modulating key molecular pathways implicated in this comorbid condition. CI - (c) 2025. The Author(s). FAU - Chen, Jie-Lin AU - Chen JL AD - Guangxi Clinical Research Center for Pediatric Diseases, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Guangxi Zhuang Autonomous Region, Nanning, 530003, China. FAU - Liu, Xiao-Juan AU - Liu XJ AD - The First Clinical Medical College of Gansu University of Chinese Medicine, Lanzhou, 730030, Gansu Province, China. FAU - Zhao, Hai-Yan AU - Zhao HY AD - Department of Pediatrics, Gansu Provincial Hospital, No.204 West Donggang Road, Lanzhou, 730030, Gansu Province, China. FAU - Zhao, Gai-Hong AU - Zhao GH AD - Department of Pediatrics, Gansu Provincial Hospital, No.204 West Donggang Road, Lanzhou, 730030, Gansu Province, China. FAU - Gao, Ming-Dong AU - Gao MD AD - Department of Pediatrics, Gansu Provincial Hospital, No.204 West Donggang Road, Lanzhou, 730030, Gansu Province, China. gmd3986@163.com. LA - eng PT - Journal Article DEP - 20251209 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - EC 1.1.1.357 (Aldo-Keto Reductase Family 1 Member C3) RN - EC 1.1.1.357 (AKR1C3 protein, human) SB - IM MH - Humans MH - *Asthma/drug therapy/genetics/etiology/complications MH - *Pediatric Obesity/complications/genetics/drug therapy MH - *Astragalus propinquus/chemistry MH - Child MH - *Aldo-Keto Reductase Family 1 Member C3/genetics/metabolism/antagonists & inhibitors MH - Molecular Docking Simulation MH - Network Pharmacology/methods MH - *Ephedra/chemistry MH - Male PMC - PMC12804807 OTO - NOTNLM OT - Asthma OT - Astragalus membranaceus OT - Ephedra OT - Key genes OT - Network pharmacology OT - Pediatric obesity COIS- Declarations. Competing interests: The authors declare no competing interests. Human ethics and consent to participate: This study was conducted in accordance with the declaration of Helsinki. This study was conducted with approval from the Ethics Committee of Gansu Provincial Hospital (No.2024 - 834). This study utilized publicly available, de-identified transcriptomic datasets from GEO. All original studies obtained participant informed consent and ethical approval. EDAT- 2025/12/10 01:47 MHDA- 2026/01/15 08:04 PMCR- 2025/12/09 CRDT- 2025/12/09 23:24 PHST- 2025/07/02 00:00 [received] PHST- 2025/12/03 00:00 [accepted] PHST- 2026/01/15 08:04 [medline] PHST- 2025/12/10 01:47 [pubmed] PHST- 2025/12/09 23:24 [entrez] PHST- 2025/12/09 00:00 [pmc-release] AID - 10.1038/s41598-025-31533-w [pii] AID - 31533 [pii] AID - 10.1038/s41598-025-31533-w [doi] PST - epublish SO - Sci Rep. 2025 Dec 9;16(1):1817. doi: 10.1038/s41598-025-31533-w. PMID- 41365980 OWN - NLM STAT- MEDLINE DCOM- 20260108 LR - 20260121 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2025 Dec 9 TI - Effect of finger millet diet on mental health and meta cognitive skills in young adult athletes and non-athletes. PG - 937 LID - 10.1038/s41598-025-30523-2 [doi] LID - 937 AB - Mental health issues are prevalent among athletes as well as non-athletes due to various psycho-physiological and environmental stresses. Finger millet being rich in antioxidants, polyphenols and high fibre, can be potentially effective in maintaining and improving mental health and cognition. Hence, the present study aims to evaluate the effects of the finger millet diet on mental health and meta-cognitive skills in athletes and non-athletes. 57 participants (males; 27 athletes and 30 non-athletes; 18 to 25 years) were randomly divided into experimental (EGA: experimental group athletes; n = 15; EGNA: experimental group non-athletes; n = 15) and control (CGA: control group athletes; n = 12; CGNA: control group non-athletes; n = 15) groups. The experimental group was provided with a finger millet diet (replacing 1/3rd of daily regular cereals) and a control group with a regular (rice/wheat) diet for 60 days. Mental health and meta-cognitive skills were measured via validated questionnaires. The SMHAT scores showed a significant decrease in sleep disturbance (p = 0.008) and a declining trend in depression (p = 0.059) and anxiety (p = 0.087) in EGA and no significant difference in CGA. The MHI scores showed significantly increased anxiety (p = 0.050), depression (p = 0.010) and psychological distress (p = 0.012) in CGNA while EGNA showed no significant difference in pre and post-test. MCSS subscales viz., implementation (p = 0.040), monitoring (p = 0.013) and total meta-cognitive skills scores showed significant improvement in EGA (p = 0.050) and no significant changes in CGA, EGNA and CGNA. Finger millet helps in improving mental health, sleep quality and meta-cognitive skills in athletes and help in the maintenance of mental health in non-athletes. CI - (c) 2025. The Author(s). FAU - Tanwar, Ekta AU - Tanwar E AD - Department of Nutrition and Dietetics, School of Allied Health Sciences, Manav Rachna International Institute of Research and Studies, Faridabad, 121004, Haryana, India. FAU - Kalpana, Kommi AU - Kalpana K AD - Department of Nutrition and Dietetics, School of Allied Health Sciences, Manav Rachna International Institute of Research and Studies, Faridabad, 121004, Haryana, India. kommikalpana80@gmail.com. FAU - Khanna, Gulshan Lal AU - Khanna GL AD - Manav Rachna International Institute of Research & Studies, Faridabad, 121004, Haryana, India. FAU - Rao, Benhur Dayakar AU - Rao BD AD - ICAR- Indian Institute of Millets Research, Hyderabad, India. FAU - Saifi, Alisha AU - Saifi A AD - Department of Nutrition and Dietetics, School of Allied Health Sciences, Manav Rachna International Institute of Research and Studies, Faridabad, 121004, Haryana, India. LA - eng GR - F. No18-3/2022-NFSM(FTS111307E/This research was funded by the Ministry of Agriculture and Farmers Welfare, Department of Agriculture and Farmers Welfare, Division of Crops and Post Harvest Management of Food Grain, Govt of India/ PT - Journal Article PT - Randomized Controlled Trial DEP - 20251209 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Male MH - Female MH - Adult MH - Young Adult MH - *Athletes/psychology MH - *Mental Health MH - *Cognition MH - Adolescent MH - *Eleusine MH - *Diet MH - Depression MH - Anxiety/diet therapy PMC - PMC12783109 OTO - NOTNLM OT - Athletes OT - Daytime sleepiness OT - Eating disorders OT - Finger millet OT - Mental health OT - Meta cognitive skills OT - Sleep quality COIS- Declarations. Competing interests: The authors declare no competing interests. Patient and public involvement: Patients and/or the public were not involved in the design, conduct, reporting, or dissemination plans of this research. Ethics approval: This study involves human participants and was approved by the Institutional Ethics Committee, Manav Rachna International Institute of Research and Studies (Ref. No: EC/2023-24/036 dated 24/07/2023) and Clinical Trial Registry of India (CTRI) (Ref No. CTRI/2023/10/059332 dated 31/10/2023). Participants gave informed consent to participate in the study before taking part. Patient and public involvement: Patients and/or the public were not involved in the design, conduct, reporting, or dissemination plans of this research. Equity, diversity and inclusion statement: All study participants were male students (aged 18 to 25 years), inclusive of all race, ethnicities, regions, religions, socioeconomic levels, and occurrences in a marginalized community. Our research team consisted of 3 females and 2 males from different disciplines (nutrition, exercise physiology and agriculture) with ranks from principal scientist to research scholars of different ethnicities, cultures, religions, geographical areas and socio-economic levels. However, all the study participants and research team belonged to the same country, India. EDAT- 2025/12/10 01:47 MHDA- 2026/01/09 00:26 PMCR- 2025/12/09 CRDT- 2025/12/09 23:21 PHST- 2024/10/24 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2026/01/09 00:26 [medline] PHST- 2025/12/10 01:47 [pubmed] PHST- 2025/12/09 23:21 [entrez] PHST- 2025/12/09 00:00 [pmc-release] AID - 10.1038/s41598-025-30523-2 [pii] AID - 30523 [pii] AID - 10.1038/s41598-025-30523-2 [doi] PST - epublish SO - Sci Rep. 2025 Dec 9;16(1):937. doi: 10.1038/s41598-025-30523-2. PMID- 41364696 OWN - NLM STAT- MEDLINE DCOM- 20251209 LR - 20251212 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 12 DP - 2025 TI - Tongue-tie diagnosis using the Lingual frenulum in newborn infants (LINNE) -scoring: A validation study. PG - e0338491 LID - 10.1371/journal.pone.0338491 [doi] LID - e0338491 AB - BACKGROUND: Ankyloglossia may restrict newborn infant's tongue movements, complicating breastfeeding. However, due to lacking evidence-based guidelines, patient selection for early frenotomy has remained a challenge. The present prospective, observation study validated a scoring aimed to detect infants who required early tongue-tie treatment. It is a part of the Lingual Frenulum in Newborn Infants (LINNE) project, investigating tongue-tie epidemiology along with a randomized treatment trial. METHODS: Healthy mother-infant-dyads were assessed by independent and mutually blinded study physicians and midwives. They used the LINNE scoring, including: 1. Infant examination using a picture assessment tool for tongue-tie in breastfed babies (TABBY); 2. Maternal breastfeeding experience scoring (MBES), a psychometric testing on acute breastfeeding symptoms; 3. Three anamnestic factors associated with tongue-ties and breastfeeding problems. Validation tests were conducted using the Cronbach alpha for the whole LINNE scoring, and for the subscorings: 1. TABBY: areas under the curve (AUC), multi-rater Fleiss kappa; 2. MBES: content and construct validity and responsiveness tests; 3. Anamnesis: accuracy studies for diagnostic tests. RESULTS: Of the studied 556 mother-infant-dyads, 72 (12.9%) infants fulfilled the early tongue-tie treatment criteria. The overall LINNE scoring's internal consistency was acceptable (alpha = 0.723). The pooled TABBY scoring (n = 1094) accurately detected the need for treatment (AUC = 0.914, 95%CI 0.891-0.938) with moderate inter-rater agreement (kappa = 0.441, 95%CI 0.406-0.477). MBES responsiveness, content, and construct validities reached the required levels. Anamnestic factors had high specificity but fair sensibility for the tongue-tie causing breastfeeding symptoms. CONCLUSION: The LINNE scoring demonstrated moderate inter-rater agreement; however, the accuracy of the TABBY tool was very good with AUC 0.9 for ankyloglossia needing early treatment. CI - Copyright: (c) 2025 Lehtinen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Lehtinen, Anu AU - Lehtinen A AD - Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, Oulu, Finland. AD - Medical Research Center, Oulu University Hospital, Oulu, Finland. AD - Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland. FAU - Lohi, Venla AU - Lohi V AD - Department of Otorhinolaryngology, Oulu University Hospital, Oulu, Finland. AD - Medical Research Center, Oulu University Hospital, Oulu, Finland. AD - Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland. FAU - Aitamurto, Stiina AU - Aitamurto S AD - Department of Otorhinolaryngology, Oulu University Hospital, Oulu, Finland. AD - Medical Research Center, Oulu University Hospital, Oulu, Finland. AD - Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland. FAU - Aikio, Outi AU - Aikio O AUID- ORCID: 0000-0001-8267-8621 AD - Department of Pediatrics and Adolescent Medicine, Oulu University Hospital, Oulu, Finland. AD - Medical Research Center, Oulu University Hospital, Oulu, Finland. AD - Research Unit of Clinical Medicine, University of Oulu, Oulu, Finland. LA - eng PT - Journal Article PT - Validation Study DEP - 20251209 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Infant, Newborn MH - *Lingual Frenum/abnormalities MH - Female MH - *Ankyloglossia/diagnosis MH - Breast Feeding MH - Male MH - Prospective Studies MH - Adult MH - *Tongue PMC - PMC12688086 COIS- The authors have declared that no competing interests exist. EDAT- 2025/12/09 19:19 MHDA- 2025/12/09 19:20 PMCR- 2025/12/09 CRDT- 2025/12/09 13:34 PHST- 2025/03/14 00:00 [received] PHST- 2025/11/21 00:00 [accepted] PHST- 2025/12/09 19:20 [medline] PHST- 2025/12/09 19:19 [pubmed] PHST- 2025/12/09 13:34 [entrez] PHST- 2025/12/09 00:00 [pmc-release] AID - PONE-D-25-09972 [pii] AID - 10.1371/journal.pone.0338491 [doi] PST - epublish SO - PLoS One. 2025 Dec 9;20(12):e0338491. doi: 10.1371/journal.pone.0338491. eCollection 2025. PMID- 41362242 OWN - NLM STAT- MEDLINE DCOM- 20260213 LR - 20260813 IS - 1475-2662 (Electronic) IS - 0007-1145 (Print) IS - 0007-1145 (Linking) VI - 135 IP - 3 DP - 2026 Feb 14 TI - Impact of early neonatal nutrition on neurodevelopment and the limbic system in very low birth weight infants. PG - 286-296 LID - 10.1017/S0007114525105874 [doi] AB - The limbic system is a brain structure involved in emotional regulation. Since nutritional interventions in very low birth weight (VLBW) infants may be associated with measurable differences in brain structure and function, we designed this prospective study to evaluate the impact of early nutritional support in VLBW infants on the volume of the regions that comprise the limbic system, as well as on the emotional and neuropsychological development of these infants. This is a prospective observational study of a historical cohort of children with a history of prematurity. Seventy-four preterm infants, with a mean age of 11.1 (sd 2.9) years, underwent neuropsychological assessment using the Wechsler Intelligence Scale for Children and functional MRI (fMRI). We recorded the nutritional intake during the first week of the neonatal period, as well as data related to neonatal morbidity. The association between the results of the brain structural analysis, psychometrics variables and nutritional intake was determined using simple and multivariate linear regression adjusted for child age and BMI in the structural analysis of fMRI. Lipids intake was also associated with the volume of the left thalamus (b = 50.7; P = 0.014), the right thalamus (b = 47.4; P = 0.018) and the left nucleus accumbens (b = 5.02; P = 0.031). We conclude that lipids intake in the first week of life in VLBW newborns is associated with the volume of various structures of the limbic system, namely the thalamus and the nucleus accumbens. FAU - Uberos, Jose AU - Uberos J AUID- ORCID: 0000-0002-3519-6678 AD - Department of Paediatrics, School of Medicine, https://ror.org/04njjy449Granada University, Granada, Spain. AD - Neonatal Intensive Care Unit, https://ror.org/02pnm9721San Cecilio Clinical Hospital, Medicine Faculty, Granada, Spain. AD - https://ror.org/026yy9j15Instituto de Investigacion Biosanitaria (ibs.GRANADA), Health Sciences Technological Park, Granada, Spain. FAU - Carrasco-Solis, Marta AU - Carrasco-Solis M AD - Neuropaediatrics Unit, Paediatrics Service, San Cecilio Clinical Hospital, Granada, Spain. AD - Center of Psychology and Neuropsychology (a)LPEH, Granada, Spain. FAU - Laynez-Rubio, Carolina AU - Laynez-Rubio C AD - Neuropaediatrics Unit, Paediatrics Service, San Cecilio Clinical Hospital, Granada, Spain. FAU - Nieto-Ruiz, Ana AU - Nieto-Ruiz A AD - Department of Behavioural Science Methodology, Faculty of Psychology, University of Granada, Granada, Spain. AD - EURISTIKOS Excellence Centre for Paediatric Research, Biomedical Research Centre, Department of Paediatrics, Faculty of Medicine, University of Granada, Granada, Spain. AD - https://ror.org/026yy9j15Instituto de Investigacion Biosanitaria (ibs.GRANADA), Health Sciences Technological Park, Granada, Spain. FAU - Ruiz-Lopez, Aida AU - Ruiz-Lopez A AD - Neonatal Intensive Care Unit, https://ror.org/02pnm9721San Cecilio Clinical Hospital, Medicine Faculty, Granada, Spain. FAU - Contreras-Chova, Francisco AU - Contreras-Chova F AD - Department of Paediatrics, School of Medicine, https://ror.org/04njjy449Granada University, Granada, Spain. FAU - Fernandez-Marin, Elizabeth AU - Fernandez-Marin E AD - Neonatal Intensive Care Unit, https://ror.org/02pnm9721San Cecilio Clinical Hospital, Medicine Faculty, Granada, Spain. FAU - Campos-Martinez, Ana AU - Campos-Martinez A AD - Department of Paediatrics, School of Medicine, https://ror.org/04njjy449Granada University, Granada, Spain. AD - Neonatal Intensive Care Unit, https://ror.org/02pnm9721San Cecilio Clinical Hospital, Medicine Faculty, Granada, Spain. AD - https://ror.org/026yy9j15Instituto de Investigacion Biosanitaria (ibs.GRANADA), Health Sciences Technological Park, Granada, Spain. CN - Collaborative NeuroPrem group LA - eng PT - Journal Article PT - Observational Study DEP - 20251209 PL - England TA - Br J Nutr JT - The British journal of nutrition JID - 0372547 SB - IM MH - Humans MH - *Infant, Very Low Birth Weight/growth & development MH - Infant, Newborn MH - *Limbic System/growth & development MH - Prospective Studies MH - Female MH - Male MH - Magnetic Resonance Imaging MH - *Infant Nutritional Physiological Phenomena MH - *Child Development MH - Infant, Premature/growth & development MH - Child MH - Neuropsychological Tests MH - Thalamus/growth & development PMC - PMC12912837 OTO - NOTNLM OT - Limbic system OT - Nucleus accumbens OT - Nutrition OT - Thalamus OT - Very low birth weight infants EDAT- 2025/12/09 07:38 MHDA- 2026/02/13 12:50 PMCR- 2026/02/17 CRDT- 2025/12/09 03:42 PHST- 2026/02/13 12:50 [medline] PHST- 2025/12/09 07:38 [pubmed] PHST- 2025/12/09 03:42 [entrez] PHST- 2026/02/17 00:00 [pmc-release] AID - S0007114525105874 [pii] AID - 10.1017/S0007114525105874 [doi] PST - ppublish SO - Br J Nutr. 2026 Feb 14;135(3):286-296. doi: 10.1017/S0007114525105874. Epub 2025 Dec 9. PMID- 41361944 OWN - NLM STAT- MEDLINE DCOM- 20251209 LR - 20260813 IS - 1469-8978 (Electronic) IS - 0033-2917 (Print) IS - 0033-2917 (Linking) VI - 55 DP - 2025 Dec 9 TI - Amygdala and insula activation in youth with avoidant/restrictive food intake disorder in response to aversive food-specific fear images. PG - e374 LID - 10.1017/S0033291725102766 [doi] LID - e374 AB - BACKGROUND: Avoidant/restrictive food intake disorder (ARFID) leads to faltering growth and psychosocial impairment. Three phenotypes can co-occur: fear of aversive consequences of eating (ARFID-fear phenotype), sensory sensitivity, and lack of interest in eating/food. We hypothesized that youth with ARFID, especially ARFID-fear phenotype, would show hyperactivation of fear-related regions in response to ARFID-specific fear images, compared to healthy controls (HC), and activation of these regions would positively correlate with ARFID fear severity. METHODS: Youth (N=103: 76 ARFID, including 20 ARFID-fear phenotype; 27 HC) underwent functional MRI scanning while viewing ARFID-specific fear (e.g. vomiting, choking) versus neutral images. We compared blood-oxygen-level-dependent (BOLD) response in fear-related region of interests (ROI; e.g. amygdala, hippocampus, insula) between ARFID and ARFID-fear phenotype versus HC. We evaluated the association between brain response and ARFID fear severity in ARFID-fear phenotype. RESULTS: Across individuals, there was a robust bilateral amygdala response to ARFID-specific fear versus neutral images. Compared to HC, ARFID-fear phenotype showed a greater insula response to ARFID-specific fear versus neutral images (p=0.049). There were no other group differences and no significant relationships between BOLD response and ARFID fear severity in ARFID-fear phenotype. CONCLUSIONS: ARFID-specific fear images elicit amygdala responses across individuals, with greater activation in the insula only in ARFID-fear phenotype versus HC. These findings validate the ARFID-specific fear paradigm and highlight the intriguing possibility that, in the ARFID-fear phenotype, universally feared experiences such as choking and vomiting serve as the unconditioned stimulus in developing ARFID and may partially be mediated by the insular cortex. FAU - Sailer, Clara O AU - Sailer CO AUID- ORCID: 0000-0001-6439-8191 AD - Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. AD - Multidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA. AD - Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Galbiati, Francesca AU - Galbiati F AUID- ORCID: 0000-0003-0744-2541 AD - Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. AD - Multidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA. AD - Division of Endocrinology, Diabetes and Hypertension, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. AD - Division of Endocrinology, Diabetes, and Metabolism, University of California San Francisco, San Francisco, USA. FAU - Holsen, Laura M AU - Holsen LM AD - Multidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA. AD - Department of Psychiatry and Division of Women's Health, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. FAU - Palmer, Lilian AU - Palmer L AUID- ORCID: 0000-0003-3608-5395 AD - Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. AD - Multidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA. FAU - Van De Water, Avery L AU - Van De Water AL AUID- ORCID: 0000-0003-3061-1964 AD - Multidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA. AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. FAU - Deckersbach, Thilo AU - Deckersbach T AUID- ORCID: 0000-0001-7643-0347 AD - University of Applied Sciences, DIPLOMA Hochschule, Bad Sooden-Allendorf, Germany. FAU - Pulumo, Reitumetse AU - Pulumo R AD - Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. AD - Multidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA. FAU - Becker, Kendra K AU - Becker KK AUID- ORCID: 0000-0002-8946-9977 AD - Multidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA. AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. AD - Department of Psychiatry, Harvard Medical School, Boston, MA, USA. FAU - Breithaupt, Lauren AU - Breithaupt L AUID- ORCID: 0000-0002-2439-6519 AD - Multidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA. AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. AD - Department of Psychiatry, Harvard Medical School, Boston, MA, USA. AD - Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA, USA. AD - Psychiatric Neuroimaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA. FAU - Fisher, Madison AU - Fisher M AD - Multidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA. AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. FAU - Asanza, Elisa AU - Asanza E AD - Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. AD - Multidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA. FAU - Hadjikhani, Nouchine AU - Hadjikhani N AUID- ORCID: 0000-0003-4075-3106 AD - Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Boston, MA, USA. AD - Psychiatric Neuroimaging Laboratory, Brigham and Women's Hospital, Boston, MA, USA. FAU - Misra, Madhusmita AU - Misra M AUID- ORCID: 0000-0002-9405-2981 AD - Multidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA. AD - Division of Pediatric Endocrinology, Department of Pediatrics, Harvard Medical School, Boston, MA, USA. FAU - Eddy, Kamryn AU - Eddy K AUID- ORCID: 0000-0002-1586-0930 AD - Multidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA. AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. AD - Department of Psychiatry, Harvard Medical School, Boston, MA, USA. FAU - Micali, Nadia AU - Micali N AUID- ORCID: 0000-0001-5571-2273 AD - Center for Eating and feeding Disorders Research, Mental Health Center Ballerup, Copenhagen University Hospital - Mental Health Services CPH, Denmark. AD - Great Ormond Street Institute of Child Health, University College London, London, United Kingdom. FAU - Lawson, Elizabeth A AU - Lawson EA AUID- ORCID: 0000-0001-8619-3349 AD - Neuroendocrine Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. AD - Multidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA. FAU - Thomas, Jennifer J AU - Thomas JJ AUID- ORCID: 0000-0003-2601-581X AD - Multidisciplinary Eating Disorders Research Collaborative, Harvard Medical School, Boston, MA, USA. AD - Eating Disorders Clinical and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. AD - Department of Psychiatry, Harvard Medical School, Boston, MA, USA. LA - eng GR - K24MH120568/MH/NIMH NIH HHS/United States GR - P30 DK040561/DK/NIDDK NIH HHS/United States GR - R01MH108595/Foundation for the National Institutes of Health/ GR - K23MH125143/National Institute of Mental Health and Neurosciences/ GR - K24MH135189/National Institute of Mental Health and Neurosciences/ GR - K23 MH125143/MH/NIMH NIH HHS/United States GR - P2BSP3_195645/Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung/ GR - UL1 TR002541/TR/NCATS NIH HHS/United States PT - Journal Article PT - Research Support, N.I.H., Extramural PT - Research Support, Non-U.S. Gov't DEP - 20251209 PL - England TA - Psychol Med JT - Psychological medicine JID - 1254142 SB - IM MH - Humans MH - *Amygdala/physiopathology/diagnostic imaging MH - Magnetic Resonance Imaging MH - Female MH - Adolescent MH - Male MH - *Fear/physiology MH - *Avoidant Restrictive Food Intake Disorder/physiopathology/diagnostic imaging MH - *Insular Cortex/physiopathology/diagnostic imaging MH - Child MH - *Cerebral Cortex/physiopathology PMC - PMC13058619 OTO - NOTNLM OT - ARFID OT - anxiety OT - feeding and eating disorders OT - food cues OT - neuroendocrinology OT - neuroimaging COIS- Drs. Thomas, Becker, and Eddy receive royalties from Cambridge University Press for the sale of their books, The Picky Eater's Recovery Book: Overcoming Avoidant/Restrictive Food Intake Disorder (2021) and Cognitive-Behavioral Therapy for Avoidant/Restrictive Food Intake Disorder: Children, Adolescents, and Adults (2019). Dr. Thomas receives royalties from Oxford University Press for the sale of her book on rumination disorder. Drs. Thomas and Eddy receive consulting fees from Equip Health. Dr. Lawson receives grant support and research study drug from Tonix Pharmaceuticals. Dr. Lawson and/or immediate family member holds/recently held stock in Thermo Fisher Scientific, Zoetis, Danaher Corporation, Intuitive Surgical, Merck, West Pharmaceutical Services, Gilead Sciences, and Illumina. Dr. Lawson is an inventor on US provisional patent application no. 63/467,980 (oxytocin-based therapeutics to improve cognitive control in individuals with attention deficit hyperactivity disorder). All other authors report no biomedical financial interests or potential conflicts of interest. EDAT- 2025/12/09 07:38 MHDA- 2025/12/09 07:39 PMCR- 2025/12/09 CRDT- 2025/12/09 01:02 PHST- 2025/12/09 07:39 [medline] PHST- 2025/12/09 07:38 [pubmed] PHST- 2025/12/09 01:02 [entrez] PHST- 2025/12/09 00:00 [pmc-release] AID - S0033291725102766 [pii] AID - 10.1017/S0033291725102766 [doi] PST - epublish SO - Psychol Med. 2025 Dec 9;55:e374. doi: 10.1017/S0033291725102766. PMID- 41361808 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260926 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2025 Dec 8 TI - Mediating pathways between area-level deprivation and hypertension in Nepal: the role of nutritional status, food insecurity, and health behaviors. PG - 172 LID - 10.1186/s12889-025-25471-5 [doi] LID - 172 AB - BACKGROUND: Hypertension is a major contributor to global disease burden, and the prevalence is associated to various social determinants, including area-level deprivation. However, the mechanisms underlying this association remain unclear, particularly in low- and middle-income countries (LMICs). This study explores how household food insecurity, individual behaviors (smoking and alcohol use), and nutritional status may mediate the relationship between area-level deprivation and hypertension in Nepal. METHODS: We used nationally representative data from the 2016 Nepal Demographic and Health Survey. Area-level deprivation was measured using a validated 15-item composite index. A two-level structural equation model was employed to analyze both the direct and indirect (mediated) relationships between deprivation and hypertension, with individuals (aged >/= 15 years) and households nested within geographic clusters/areas. RESULTS: The overall prevalence of hypertension was 22.9%, with a higher rate in less deprived (more affluent) areas (27.5%) compared to highly deprived ones (17.9%). When mediators were not included, area-level deprivation was inversely associated with hypertension. However, when potential mediators-Body Mass Index (BMI; as a proxy for nutritional status), household food insecurity, and individual behaviors (smoking and alcohol use) were included, the direct effect of deprivation on hypertension was no longer significant. BMI emerged as the only significant mediator, accounting for approximately 70% of the total indirect effect. Food insecurity and individual behaviors did not significantly mediate the relationship; although, food insecurity was associated with lower hypertension risk and individual health behaviors (smoking and alcohol use) with higher risk at the individual level. CONCLUSION: In the context of Nepal, hypertension is more prevalent in affluent areas, and BMI- a proxy for nutritional status significantly mediates the link between area-level deprivation and hypertension risk. These findings highlight the role of nutritional transitions in LMICs and the need for context-specific public health strategies targeting both environmental and individual-level factors. FAU - Sharma, Ishor AU - Sharma I AD - Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. isharm9@uwo.ca. FAU - Campbell, M Karen AU - Campbell MK AD - Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. AD - Department of Pediatrics, Western University, London, ON, Canada. AD - Children's Health Research Institute, London, ON, Canada. AD - Lawson Health Research Institute, London, ON, Canada. AD - Department of Obstetrics and Gynecology, Western University, London, ON, Canada. FAU - Choi, Yun-Hee AU - Choi YH AD - Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. FAU - Luginaah, Isaac AU - Luginaah I AD - Department of Geography, Western University, London, ON, Canada. FAU - Were, Jason Mulimba AU - Were JM AD - Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. FAU - Vargas-Gonzalea, Juan-Camilo AU - Vargas-Gonzalea JC AD - Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. FAU - Stranges, Saverio AU - Stranges S AD - Department of Epidemiology and Biostatistics, Western University, London, ON, Canada. AD - Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy. AD - The Africa Institute, Western University, London, ON, Canada. AD - Department of family Medicine, Western University, London, ON, Canada. AD - Department of Medicine, Schulich school of medicine and Dentistry, Western University, London, ON, Canada. LA - eng PT - Journal Article DEP - 20251208 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Nepal/epidemiology MH - *Hypertension/epidemiology MH - *Food Insecurity MH - *Nutritional Status MH - Female MH - *Health Behavior MH - Adult MH - Male MH - Adolescent MH - Health Surveys MH - Middle Aged MH - Young Adult MH - Socioeconomic Disparities in Health MH - Prevalence MH - Poverty PMC - PMC12802185 OTO - NOTNLM OT - Area-level deprivation OT - Hypertension OT - Multilevel-Mediation COIS- Declarations. Ethics approval and consent to participate: Not Applicable. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/09 07:38 MHDA- 2026/06/27 00:59 PMCR- 2025/12/08 CRDT- 2025/12/09 00:26 PHST- 2025/06/22 00:00 [received] PHST- 2025/10/28 00:00 [accepted] PHST- 2026/06/27 00:59 [medline] PHST- 2025/12/09 07:38 [pubmed] PHST- 2025/12/09 00:26 [entrez] PHST- 2025/12/08 00:00 [pmc-release] AID - 10.1186/s12889-025-25471-5 [pii] AID - 25471 [pii] AID - 10.1186/s12889-025-25471-5 [doi] PST - epublish SO - BMC Public Health. 2025 Dec 8;26(1):172. doi: 10.1186/s12889-025-25471-5. PMID- 41361802 OWN - NLM STAT- MEDLINE DCOM- 20260114 LR - 20260116 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2025 Dec 9 TI - Social and socioeconomic determinants of health and contraceptive decision-making among women: a cross-sectional study from southeastern Iran. PG - 179 LID - 10.1186/s12889-025-25878-0 [doi] LID - 179 AB - BACKGROUND: Women's ability to choose contraceptive methods and shape their reproductive behaviors can significantly improve their reproductive health. However, various factors influence these patterns. This study aimed to examine the socioeconomic determinants affecting contraceptive method choice among women in Zahedan. METHODS: This study included 3,140 women from the Zahedan Cohort Study (October 2015-January 2019). Demographic, fertility, anthropometric, and disease data were collected using a validated questionnaire. Analyses were performed using SPSS version 26. Chi-square tests assessed associations between categorical variables, and variables with p < 0.20 or clinically relevant were entered into a multivariable logistic regression model (effective vs. less-effective contraceptive methods). Adjusted odds ratios (AORs) with 95% confidence intervals (CIs) were reported; p < 0.05 was considered statistically significant. RESULTS: Use of less effective contraception was significantly associated with several factors: it decreased with age (OR = 0.60, p = 0.002) and higher education levels (OR = 1.60, p = 0.001). Underweight individuals were more likely to use less effective methods compared to obese individuals (OR = 1.75, p = 0.007). Higher rates of less effective contraception use were also observed among the very poor (OR = 1.36, p = 0.002) and poor (OR = 1.28, p = 0.01), while women with gestational hypertension (OR = 0.74, p = 0.02) or diabetes (OR = 0.62, p = 0.001) were less likely to use these methods. CONCLUSION: The results of this study indicate that contraceptive method choice is influenced by various factors, including age, body mass index, economic status, and pregnancy complications. These findings underscore the importance of targeted educational interventions and socioeconomic support to encourage the use of safer contraceptive methods among women. CI - (c) 2025. The Author(s). FAU - Shahraki-Sanavi, Fariba AU - Shahraki-Sanavi F AUID- ORCID: 0000-0002-6937-0793 AD - Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. FAU - Moghaddam, Alireza Ansari AU - Moghaddam AA AUID- ORCID: 0000-0002-3267-7193 AD - Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. FAU - Mohammadi, Mahdi AU - Mohammadi M AUID- ORCID: 0000-0001-9616-6125 AD - Health Promotion Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. FAU - Khazaeian, Somayyeh AU - Khazaeian S AUID- ORCID: 0000-0002-5596-4937 AD - Pregnancy Health Research Center, Faculty of Nursing and Midwifery, Zahedan University of Medical Sciences, Zahedan, Iran. khazaeiansomayyeh@gmail.com. LA - eng PT - Journal Article DEP - 20251209 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Adult MH - Iran MH - *Contraception Behavior/statistics & numerical data MH - Young Adult MH - Socioeconomic Factors MH - *Social Determinants of Health/statistics & numerical data MH - *Decision Making MH - *Contraception/statistics & numerical data MH - Surveys and Questionnaires MH - Adolescent MH - Middle Aged PMC - PMC12801653 OTO - NOTNLM OT - Contraceptives OT - Reproductive health OT - Socioeconomic factors OT - Women COIS- Declarations. Ethics approval and consent to participate: The Persian Cohort Study received ethical approval from the Ministry of Health and Zahedan University of Medical Sciences (IDs: IR.ZAUMS.REC.1393-96451 and IR.ZAUMS.REC.1402.111 for the present sub-study). The study was conducted in accordance with the Declaration of Helsinki (1975). Written informed consent was obtained from all participants after explaining the study objectives. Participation was voluntary, confidentiality was ensured, and withdrawal was permitted at any stage. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/09 07:38 MHDA- 2026/01/14 07:06 PMCR- 2025/12/09 CRDT- 2025/12/09 00:25 PHST- 2025/04/27 00:00 [received] PHST- 2025/11/29 00:00 [accepted] PHST- 2026/01/14 07:06 [medline] PHST- 2025/12/09 07:38 [pubmed] PHST- 2025/12/09 00:25 [entrez] PHST- 2025/12/09 00:00 [pmc-release] AID - 10.1186/s12889-025-25878-0 [pii] AID - 25878 [pii] AID - 10.1186/s12889-025-25878-0 [doi] PST - epublish SO - BMC Public Health. 2025 Dec 9;26(1):179. doi: 10.1186/s12889-025-25878-0. PMID- 41361405 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20251212 IS - 1471-2334 (Electronic) IS - 1471-2334 (Linking) VI - 25 IP - 1 DP - 2025 Dec 8 TI - Sero-prevalence and associated factors of transfusion-transmitted infections of HBV, HCV, HIV, and syphilis among voluntary blood donors in Gondar District Blood Bank, Ethiopia: a retrospective study. PG - 1699 LID - 10.1186/s12879-025-12059-y [doi] LID - 1699 AB - BACKGROUND: Blood transfusion is a life-saving intervention performed worldwide; however, it remains a significant public health concern due to the risk of transfusion-transmitted infections (TTIs). Globally, millions are infected with hepatitis B virus (HBV), hepatitis C virus (HCV), human immunodeficiency virus (HIV), and Treponema pallidum (syphilis) through unsafe blood transfusion practices. In resource-limited settings like Ethiopia, ensuring blood safety is especially challenging due to inadequate screening and surveillance systems. This study aimed to assess the prevalence and associated risk factors of HBV, HCV, HIV, and syphilis among voluntary blood donors in the North Gondar District Blood Bank, Northwest Ethiopia. METHOD: A retrospective cross-sectional study was conducted using data from 265 voluntary blood donors at the North Gondar District Blood Bank, collected between February 15, 2021, and May 24, 2022. Data were retrieved from the blood bank records between June 1 and June 15, 2022. Donor sociodemographic characteristics and transfusion-transmitted infection (TTI) screening results were extracted from these records. Descriptive statistics were used to estimate prevalence. Variables with a p-value < 0.25 in Bivariable analysis were included in a multivariable logistic regression model to identify independent predictors of TTIs. Multicollinearity was assessed using the variance inflation factor (VIF), and model fitness was evaluated using the Hosmer-Lemeshow goodness-of-fit test. A p-value < 0.05 was considered statistically significant. RESULT: The study covered 265 blood donors in the Gondar blood bank district between February 15, 2021, and May 24, 2022. The total sero-prevalence of HIV, HCV, HBV and syphilis during the follow-up period was 2.26%, 2.64%, 4.53%, and 7.17%, respectively. Age groups of 26-35 for blood donors screening for HCV (AOR = 2.1, 95% CI 1.1, 3.29), Male donors (AOR = 1.2, 95% CI 1.10, 6.52), age groups of 26-35 for screening for HBV (AOR = 1.1, 95% CI 1.00, 1.24), age groups greater than 45 for screening for Treponema pallidum (AOR = 8.6, 95% CI 7.44, 10.02), and divorced marital status (AOR = 2.1, 95% CI 1.64, 6.94) were significantly associated with the prevalence of Sero-prevalence trans-fusion transmissible infections occurrence. CONCLUSION: This study found that the overall sero-prevalence of TTIs among blood donors in North Gondar was notable, with HCV (4.53%) and syphilis (7.17%) being the most prevalent. Statistically significant associations were observed between HCV and the 26-35 age group, syphilis and donors aged above 45, HBV and the 26-35 age group, male gender with TTIs, and divorced marital status with syphilis. These findings underscore the need for more targeted donor screening strategies focusing on these high-risk groups to enhance transfusion safety. Further studies with larger sample sizes are recommended to validate these associations and explore additional risk factors. CLINICAL TRIAL NUMBER: was not applicable in the study. CI - (c) 2025. The Author(s). FAU - Dagnaw, Mequanente AU - Dagnaw M AUID- ORCID: 0009-0006-0290-9025 AD - Department of Epidemiology and Biostatistics, Institute of Public Health, University of Gondar, Gondar, Ethiopia. mequanente@gmail.com. AD - Department of Medical Biotechnology, Institute of Biotechnology, University of Gondar, Gondar, Ethiopia. mequanente@gmail.com. FAU - Merawie, Destaw Marie AU - Merawie DM AD - Department of Physiotherapy, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. FAU - Yirsa, Tsedalu AU - Yirsa T AD - Department of Veterinary Medicine, College of Agriculture and Natural Resources, Woldia University, Woldia, Ethiopia. FAU - Gobezie, Melese AU - Gobezie M AD - Department of Physiotherapy, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia. LA - eng PT - Journal Article DEP - 20251208 PL - England TA - BMC Infect Dis JT - BMC infectious diseases JID - 100968551 SB - IM MH - Humans MH - Retrospective Studies MH - Ethiopia/epidemiology MH - *Blood Donors MH - Blood Transfusion MH - Cross-Sectional Studies MH - *Transfusion Reaction/epidemiology MH - Adolescent MH - Adult MH - Middle Aged MH - Aged MH - Hepatitis B/transmission MH - Hepatitis C/transmission MH - HIV Infections/transmission MH - Syphilis/transmission PMC - PMC12683912 OTO - NOTNLM OT - Blood donors OT - Ethiopia OT - HBV OT - HCV OT - HIV OT - Sero-prevalence OT - Syphilis COIS- Declarations. Ethics approval and consent to participate: Ethical clearance for this study was obtained from the Institutional Review Board (IRB) of the GT Technology collage (Reference No. GTC/21/08/2022). Informed consent was not used because the study was retrospective. But by keeping the information that was extracted private and making sure that it could only be utilized for study-related objectives, the data's secrecy was preserved. The participant's informed consent waiver was authorized by the institutional ethical review board of the GT Technology College in Gondar, Ethiopia. The study was conducted in accordance with the ethical principles outlined in the Declaration of Helsinki (2013 version). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/09 00:31 MHDA- 2025/12/09 07:21 PMCR- 2025/12/08 CRDT- 2025/12/08 23:44 PHST- 2025/03/14 00:00 [received] PHST- 2025/10/30 00:00 [accepted] PHST- 2025/12/09 07:21 [medline] PHST- 2025/12/09 00:31 [pubmed] PHST- 2025/12/08 23:44 [entrez] PHST- 2025/12/08 00:00 [pmc-release] AID - 10.1186/s12879-025-12059-y [pii] AID - 12059 [pii] AID - 10.1186/s12879-025-12059-y [doi] PST - epublish SO - BMC Infect Dis. 2025 Dec 8;25(1):1699. doi: 10.1186/s12879-025-12059-y. PMID- 41361209 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260813 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Dec 8 TI - Artificial intelligence model as a tool to predict prediabetes. PG - 43421 LID - 10.1038/s41598-025-23227-0 [doi] LID - 43421 AB - Prediabetes is characterized by elevated blood glucose levels that are higher than normal but below the threshold for diabetes mellitus. While AI models have been used for prediabetes prediction, most rely solely on standard clinical and biochemical markers. This study introduces a novel Pattern Neural Network (PNN) model that uniquely integrates total antioxidant scavenging potential with traditional risk factors, providing new insights into the role of oxidative stress in prediabetes risk stratification among Indian adults. A total of 199 individuals aged 18 to 60 years were recruited and classified based on HbA1c levels into Control (n = 99) and Prediabetes (n = 100) groups. Fourteen input features including age, gender, total antioxidant status, HbA1c, FBG, OGTT, TGL, HDL, LDL, VLDL, TC, WC, Hb, and BMI were used to train a PNN with 14 input nodes, 10 hidden nodes, and one output node. The dataset was randomly divided into training, validation, and testing subsets. Model performance was compared against SVM, KNN, and LR classifiers. Feature importance analysis was conducted to interpret the model's clinical relevance. The PNN model achieved superior validation performance with an accuracy of 98.3%, outperforming SVM (96%), KNN (83%), and LR (71%). Notably, antioxidant scavenging potential and waist circumference emerged as the most influential predictors. The model's output value of 0.8770 (threshold > 0.5) effectively identified individuals at increased risk of developing diabetes. By incorporating oxidative stress markers, this study provides the first AI model in an Indian cohort to link antioxidant status to prediabetes risk. The PNN model demonstrates excellent accuracy and interpretability, offering a clinically actionable tool for early disease detection and personalized intervention. FAU - Yesupatham, Aarthi AU - Yesupatham A AD - Department of Biomedical Sciences, 120TT Biomedical Genetics Research Laboratory, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India. FAU - Das, Raja AU - Das R AD - Department of Mathematics, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu, India. FAU - Bharani, Go AU - Bharani G AD - Department of General Medicine, Mothers Care Diabetes Centre, Vellore, Tamil Nadu, India. FAU - Shaikmeeran, Meera AU - Shaikmeeran M AD - Department of Community Medicine, Government Vellore Medical College, Vellore, Tamil Nadu, India. FAU - Saraswathy, Radha AU - Saraswathy R AD - Department of Biomedical Sciences, 120TT Biomedical Genetics Research Laboratory, School of Biosciences and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, India. radhasaraswathy@vit.ac.in. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251208 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 RN - 0 (Blood Glucose) RN - 0 (Glycated Hemoglobin) RN - 0 (Biomarkers) SB - IM MH - *Prediabetic State/diagnosis/blood MH - Humans MH - *Artificial Intelligence MH - Adult MH - Female MH - Male MH - Prediction Algorithms MH - Middle Aged MH - Blood Glucose/analysis MH - Adolescent MH - Predictive Learning Models MH - Young Adult MH - Neural Networks, Computer MH - Classification Algorithms MH - Glycated Hemoglobin/analysis MH - Risk Factors MH - Oxidative Stress MH - Biomarkers/blood PMC - PMC12689726 OTO - NOTNLM OT - Artificial intelligence OT - Biochemical parameters OT - K-Nearest neighbors (KNN) OT - Logistic regression OT - Pattern neural network OT - Prediabetes OT - Support vector machines COIS- Declarations. Competing interests: The authors declare no competing interests. Human ethics and consent to participate declarations: This study was conducted in accordance with the ethical principles of the Declaration of Helsinki. The research protocol was approved by respective Institutional Ethics committee for Studies on Human subjects. The study received ethical approval from the Institutional Ethics Committee of Vellore Institute of Technology, Vellore (VIT/IECH/XIV/2023/01), Government Vellore Medical College & Hospital, Vellore (GVMCH) (VMC/III/00001/2023), and the Directorate of Public Health and Preventive Medicine, Chennai (DPH) (DPHPM/DPHSAC/2023/250). All participants were informed about the study's objectives and procedures, and written informed consent was obtained prior to enrolment. EDAT- 2025/12/09 00:32 MHDA- 2026/06/27 12:39 PMCR- 2025/12/08 CRDT- 2025/12/08 23:33 PHST- 2025/07/04 00:00 [received] PHST- 2025/10/06 00:00 [accepted] PHST- 2026/06/27 12:39 [medline] PHST- 2025/12/09 00:32 [pubmed] PHST- 2025/12/08 23:33 [entrez] PHST- 2025/12/08 00:00 [pmc-release] AID - 10.1038/s41598-025-23227-0 [pii] AID - 23227 [pii] AID - 10.1038/s41598-025-23227-0 [doi] PST - epublish SO - Sci Rep. 2025 Dec 8;15(1):43421. doi: 10.1038/s41598-025-23227-0. PMID- 41360460 OWN - NLM STAT- MEDLINE DCOM- 20251208 LR - 20260106 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 12 DP - 2025 Dec 7 TI - Matrix-directed therapy losartan to identify the effect on the bone resorption marker carboxy-terminal crosslink of type I collagen telopeptide (CTX) in older adolescents and adults with osteogenesis imperfecta recruited from secondary care sites: the 'MOI-A' study; a randomised, phase 2/pilot, dose-escalating trial. PG - e107243 LID - 10.1136/bmjopen-2025-107243 [doi] LID - e107243 AB - INTRODUCTION: Osteogenesis imperfecta (OI) is the most common inherited cause of bone fragility (approximately 1 in 16 000). People with OI suffer bone fragility causing fractures, pain and deformity; sarcopenia causing fatigue and poor endurance; aortic root dilatation and hearing loss. No drug currently has market authorisation to treat OI in Europe. Current standard-of-care is multidisciplinary, with pharmacological interventions-primarily bisphosphonates-directed at increasing bone mass; however, such interventions are of equivocal efficacy. The structural damage that can accumulate as a result of repeated fractures over time may not be reversible. The lack of a treatment with clearly defined efficacy in terms of reducing fracture frequency or the sarcopenia, that is increasingly recognised in this condition, leads to the consideration of alternatives based on what is known about the molecular pathophysiology of the condition. For reasons that are currently unclear, transforming growth factor beta (TGFbeta) pathway signalling is increased in OI, and both studies in mouse models and more recently also in humans suggest that reducing TGFbeta pathway signalling could be of benefit in OI. This demonstrator project tests the hypothesis that losartan, an antihypertensive agent known to reduce circulating TGFbeta, will reduce bone turnover and bone loss and have a positive effect on muscle function and quality of life in adults and older adolescents with OI. METHODS AND ANALYSIS: This is a phase 2/pilot, open-label, dose-escalating study. This study aims to identify the effective dose for losartan in this population to inform the design of a pivotal phase III study. The study aims to recruit 30 adolescents and adults aged 16 years and above with OI across secondary care study sites in the UK and Italy. Participants will be recruited from the patient populations attending for treatment of OI at the participating hospital sites or referred by clinicians at the Participant Identification Centres (PIC sites). Participants will be randomised to one of three 'final doses'-25, 50 or 75 mg losartan once daily. All participants will start on 25 mg once daily. Those assigned to higher 'final doses' will increase in 25 mg once daily increments on day 8 and day 15 following safety assessments. The primary outcome measures are to establish the effective dose of losartan in OI patients, based on maximal reduction in the bone resorption marker carboxy-terminal crosslink of type I collagen telopeptide (CTX) over the 24-week period of the study.Secondary outcome measures are to determine the changes in proxy efficacy outcomes for bone (turnover, mass, architecture and strength) using blood tests, high-resolution peripheral quantitative CT (HRpQCT), dual-energy X-ray absorptiometry (DXA) and muscle (strength) using the 'Timed Up and Go' test. In addition, the changes in quality of life, including pain and fatigue, will be evaluated by using a disease-specific tool (OI-QOL) and a validated generic tool (EQ-5D-5L-VAS). ETHICS AND DISSEMINATION: In the UK, the study protocol and amendments have been approved by the London Bridge Research Ethics Committee (REC reference: 23/LO/015) and by the Medicines and Healthcare products Regulatory Agency (MHRA). In Italy, the study protocol and amendments have been approved by the Italian and European ethics and regulatory authorities (Clinical Trials Information System European Union (CTIS EU) portal according to EU Regulation 536/2014). Final version of study protocol: Version 3.2, 05.03.2025. Final results will be disseminated in peer-reviewed journals through local OI, orthopaedic and other relevant clinical networks and at national and international meetings. Sheffield Children's National Health Service Foundation Trust (UK) and Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Istituto Ortopedico Rizzoli (Italy) are the joint study sponsors. TRIAL REGISTRATION NUMBER: ISRCTN (ISRCTN13317811). CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Haji Sadeghi, Mahboobeh AU - Haji Sadeghi M AUID- ORCID: 0000-0002-0332-6933 AD - Hull Health Trials Unit, University of Hull, Hull, UK mahboobeh.hajisadeghi@hyms.ac.uk. FAU - Cohen, Judith AU - Cohen J AUID- ORCID: 0000-0002-1538-3521 AD - Hull Health Trials Unit, University of Hull, Hull, UK. FAU - Williams, Bronwen AU - Williams B AD - Hull Health Trials Unit, University of Hull, Hull, UK. FAU - Wilkinson, Amy AU - Wilkinson A AD - Hull Health Trials Unit, University of Hull, Hull, UK. FAU - Sumpter, Sarah AU - Sumpter S AD - Hull Health Trials Unit, University of Hull, Hull, UK. FAU - Simms, Laura AU - Simms L AUID- ORCID: 0009-0009-7950-5178 AD - Hull Health Trials Unit, University of Hull, Hull, UK. FAU - Huang, Chao AU - Huang C AUID- ORCID: 0000-0002-3627-7218 AD - Hull Health Trials Unit, University of Hull, Hull, UK. FAU - Pugh, Keith AU - Pugh K AD - Sheffield Children's NHS Foundation Trust, Sheffield, UK. FAU - Heath, Charlotte AU - Heath C AUID- ORCID: 0009-0001-4819-9114 AD - Sheffield Children's NHS Foundation Trust, Sheffield, UK. FAU - Sangiorgi, Luca AU - Sangiorgi L AD - IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. FAU - Gurioli, Francesca AU - Gurioli F AUID- ORCID: 0009-0006-4284-8618 AD - IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. FAU - Gnoli, Maria AU - Gnoli M AUID- ORCID: 0000-0002-5907-7470 AD - IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. FAU - Moroni, Alice AU - Moroni A AUID- ORCID: 0000-0002-4777-341X AD - IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. FAU - Leopardi, Martina Piccinni AU - Leopardi MP AD - IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. FAU - Del Coco, Clara AU - Del Coco C AD - IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy. FAU - Bishop, Nick AU - Bishop N AUID- ORCID: 0000-0001-7263-8546 AD - Sheffield Children's NHS Foundation Trust, Sheffield, UK. AD - The University of Sheffield, Sheffield, UK. LA - eng PT - Journal Article DEP - 20251207 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 RN - JMS50MPO89 (Losartan) RN - 0 (Collagen Type I) RN - 0 (Biomarkers) RN - 0 (collagen type I trimeric cross-linked peptide) RN - 0 (Peptides) RN - 0 (Angiotensin II Type 1 Receptor Blockers) SB - IM MH - Humans MH - *Osteogenesis Imperfecta/drug therapy MH - Adolescent MH - *Losartan/administration & dosage/therapeutic use MH - *Collagen Type I/blood MH - Adult MH - Biomarkers/blood MH - Female MH - Male MH - *Peptides/blood MH - *Bone Resorption/drug therapy MH - Young Adult MH - *Angiotensin II Type 1 Receptor Blockers/administration & dosage/therapeutic use MH - Randomized Controlled Trials as Topic MH - Middle Aged MH - Clinical Trials, Phase II as Topic PMC - PMC12684106 OTO - NOTNLM OT - Adolescent OT - Body Mass Index OT - Bone diseases OT - Musculoskeletal disorders COIS- Competing interests: NJB is global CI for the Ultragenyx/Mereo Biopharma sponsored studies (ORBIT and COSMIC) of setrusumab in children and young adults with OI. All other authors have no competing interest to declare. EDAT- 2025/12/09 00:32 MHDA- 2025/12/09 00:33 PMCR- 2025/12/07 CRDT- 2025/12/08 20:43 PHST- 2025/12/09 00:33 [medline] PHST- 2025/12/09 00:32 [pubmed] PHST- 2025/12/08 20:43 [entrez] PHST- 2025/12/07 00:00 [pmc-release] AID - bmjopen-2025-107243 [pii] AID - 10.1136/bmjopen-2025-107243 [doi] PST - epublish SO - BMJ Open. 2025 Dec 7;15(12):e107243. doi: 10.1136/bmjopen-2025-107243. PMID- 41360203 OWN - NLM STAT- MEDLINE DCOM- 20260130 LR - 20260516 IS - 1095-8304 (Electronic) IS - 0195-6663 (Linking) VI - 219 DP - 2026 Apr 1 TI - Parenting and schema domains as predictors of intuitive and dysregulated eating in emerging adults. PG - 108413 LID - S0195-6663(25)00566-5 [pii] LID - 10.1016/j.appet.2025.108413 [doi] AB - Emerging adulthood is a period when enduring eating patterns consolidate and guide daily food choices. This cross-sectional study examined whether perceived parenting and early maladaptive schema (EMS) domains were associated with intuitive eating, cognitive restraint, emotional eating, and uncontrolled eating among Turkish emerging adults (N = 446). Participants completed validated measures of intuitive and dysregulated eating, maternal/paternal warmth, overprotection, rejection, and five EMS domains. Hierarchical regressions entered demographics and lifestyle factors (Step 1), parenting (Step 2), and EMS domains (Step 3). Exploratory mediation models tested indirect pathways from parenting to eating through EMS domains while adjusting for the same covariates. Men reported higher intuitive eating, whereas women reported greater restraint and emotional eating. Dieting history, higher body mass index, and weight dissatisfaction were consistently associated with lower intuitive eating and higher dysregulated patterns. Parenting contributed modestly to model fit, whereas EMS domains accounted for additional, larger variance. Mediation analyses indicated three indirect pathways: higher maternal warmth related to lower Impaired Autonomy/Performance (IAP), which was associated with higher intuitive eating; higher maternal rejection related to higher IAP, which was associated with greater emotional eating; and higher maternal overprotection related to higher IAP and Other-Directedness, which were associated with greater uncontrolled eating. In final models, maternal warmth related positively to intuitive eating, while IAP-and for uncontrolled eating, Other-Directedness-showed robust links with dysregulated eating. Findings support a layered pattern of associations in which caregiving climates and enduring schemas make separable contributions to appetite-related regulation. CI - Copyright (c) 2025 Elsevier Ltd. All rights reserved. FAU - Kilcik, Deniz Gozde AU - Kilcik DG AD - Graduate Researcher, Psychological Counselor, Turkiye. Electronic address: denizgozdekilcik@gmail.com. FAU - Akfirat, Osman Nejat AU - Akfirat ON AD - Department of Guidance and Psychological Counseling, Kocaeli University, Turkiye. Electronic address: nejat.akfirat@kocaeli.edu.tr. LA - eng PT - Journal Article DEP - 20251206 PL - England TA - Appetite JT - Appetite JID - 8006808 SB - IM MH - Humans MH - Female MH - Male MH - *Parenting/psychology MH - Cross-Sectional Studies MH - Young Adult MH - *Feeding Behavior/psychology MH - Adult MH - Adolescent MH - Intuition MH - Body Mass Index MH - Emotions MH - *Feeding and Eating Disorders/psychology MH - *Eating/psychology OTO - NOTNLM OT - Cognitive restraint OT - Early maladaptive schemas OT - Emotional eating OT - Intuitive eating OT - Parenting OT - Uncontrolled eating COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/09 00:31 MHDA- 2026/01/31 00:29 CRDT- 2025/12/08 19:29 PHST- 2025/08/20 00:00 [received] PHST- 2025/11/19 00:00 [revised] PHST- 2025/12/05 00:00 [accepted] PHST- 2026/01/31 00:29 [medline] PHST- 2025/12/09 00:31 [pubmed] PHST- 2025/12/08 19:29 [entrez] AID - S0195-6663(25)00566-5 [pii] AID - 10.1016/j.appet.2025.108413 [doi] PST - ppublish SO - Appetite. 2026 Apr 1;219:108413. doi: 10.1016/j.appet.2025.108413. Epub 2025 Dec 6. PMID- 41359940 OWN - NLM STAT- MEDLINE DCOM- 20260123 LR - 20260123 IS - 1533-4287 (Electronic) IS - 1064-8011 (Linking) VI - 40 IP - 2 DP - 2026 Feb 1 TI - Agreement Between a Motorized Resistance Device and Traditional Systems for Sprint and Change-of-Direction Testing in Female Volleyball Players. PG - 198-205 LID - 10.1519/JSC.0000000000005290 [doi] AB - Wright, WC, Aguiar, EJ, Winchester, LJ, Fedewa, MV, and Esco, MR. Agreement between a motorized resistance device and traditional systems for sprint and change-of-direction testing in female volleyball players. J Strength Cond Res 40(2): 198-205, 2026-The purpose of this study was to determine the agreement between a motorized sprint resistance device (MSRD) and timing gates and an inertial measurement unit (IMU), for assessing time to completion and peak velocity during linear and change-of-direction tasks in elite female volleyball players. Elite volleyball athletes ( n = 16, 19.4 +/- 1.5 years, 176.2 +/- 10.6 cm, 71.5 +/- 11.1 kg) performed the 18.29 m sprint and 5-10-5 drills while being simultaneously assessed using an MSRD, timing gates, and an IMU. Compared with timing gates for measuring sprint (3.09 +/- 0.16 seconds) and 5-10-5 (5.08 +/- 0.19 seconds) time, the MSRD showed significant ( p < 0.01) mean differences (3.15 +/- 0.17 seconds [ p < 0.01, Cohen's d = 0.49, small ]) and 5.16 +/- 0.21 seconds [ p < 0.01, Cohen's d = 1.14, moderate ], respectively, but the correlations were very large to nearly perfect ( r = 0.97 and 0.87, respectively). Limits of agreement (LOA) for sprint time were -0.10 +/- 0.10 seconds and for 5-10-5 time were 0.23 +/- 0.24 seconds. For peak velocity, the mean values from MSRD and IMU for the sprint (4.62 +/- 0.34 m.s -1 and 4.72 +/- 0.44 m.s -1 , respectively [ p = 0.78]) and 5-10-5 drill (3.91 +/- 0.47 m.s -1 and 3.93 +/- 0.50 m.s -1 , respectively [ p = 0.98]) were not significantly different. The correlation between the peak velocity values was significant for the sprint ( r = 0.65, p < 0.01), but not for 5-10-5 ( r = 0.25, p = 0.69), with LOA values of 0.03 +/- 0.86 m.s -1 and 0.00 +/- 0.98 m.s -1 , respectively. The MSRD seems to agree with timing gates for sprint and 5-10-5 time. However, the agreement with IMU for peak velocity is weaker. CI - Copyright (c) 2025 National Strength and Conditioning Association. FAU - Wright, Will C AU - Wright WC AD - Department of Kinesiology, The University of Alabama, Tuscaloosa, AL; and. AD - Department of Athletics, Jacksonville State University, Jacksonville, AL. FAU - Aguiar, Elroy J AU - Aguiar EJ AD - Department of Kinesiology, The University of Alabama, Tuscaloosa, AL; and. FAU - Winchester, Lee J AU - Winchester LJ AD - Department of Kinesiology, The University of Alabama, Tuscaloosa, AL; and. FAU - Fedewa, Michael V AU - Fedewa MV AD - Department of Kinesiology, The University of Alabama, Tuscaloosa, AL; and. FAU - Esco, Michael R AU - Esco MR AD - Department of Kinesiology, The University of Alabama, Tuscaloosa, AL; and. LA - eng PT - Journal Article DEP - 20251205 PL - United States TA - J Strength Cond Res JT - Journal of strength and conditioning research JID - 9415084 SB - IM MH - Humans MH - *Volleyball/physiology MH - Female MH - *Athletic Performance/physiology MH - Young Adult MH - *Running/physiology MH - *Resistance Training/instrumentation MH - *Exercise Test/instrumentation/methods MH - Adolescent OTO - NOTNLM OT - L-drill OT - T-test OT - agility OT - female athletes OT - performance testing OT - pro-agility test EDAT- 2025/12/08 19:23 MHDA- 2026/01/23 18:36 CRDT- 2025/12/08 16:33 PHST- 2026/01/23 18:36 [medline] PHST- 2025/12/08 19:23 [pubmed] PHST- 2025/12/08 16:33 [entrez] AID - 00124278-990000000-00858 [pii] AID - 10.1519/JSC.0000000000005290 [doi] PST - ppublish SO - J Strength Cond Res. 2026 Feb 1;40(2):198-205. doi: 10.1519/JSC.0000000000005290. Epub 2025 Dec 5. PMID- 41358232 OWN - NLM STAT- MEDLINE DCOM- 20251208 LR - 20251210 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Development and interpretation of a machine learning model for predicting body mass index in Chinese adolescents: a prospective cohort study. PG - 1657551 LID - 10.3389/fpubh.2025.1657551 [doi] LID - 1657551 AB - PURPOSES: This study aimed to develop a machine learning model to predict body mass index (BMI) in adolescents based on readily accessible daily information and to investigate the influence of modifiable factors on BMI changes through model interpretation techniques. METHODS: This study is a one-year prospective cohort study. Baseline data were collected through anthropometric measurements and questionnaires, and BMI were reassessed after 1 year. Six machine learning models were developed to predict BMI. Nested cross-validation (CV) was used for hyperparameter tuning and performance estimation. Predictors were prescreened on the inner-training folds of the nested CV using univariable analyses. Model performance was evaluated using Root Mean Squared Error (RMSE), Mean Squared Error (MSE), Mean Absolute Error (MAE), and coefficient of determination (R(2)). SHapley Additive exPlanations (SHAP) was used for global and local interpretations of the models. RESULTS: The mean BMI of the 1,827 students included in the final analysis increased from 21.18 +/- 3.63 kg/m(2) at baseline to 21.54 +/- 3.59 kg/m(2) after 1 year, with an average change of 0.36 +/- 1.40 kg/m(2). The CatBoost (CB) model demonstrated the best predictive performance. After calibration, it achieved an RMSE of 1.200 [95% confidence interval (CI): 1.101-1.303], MSE of 1.440 (95% CI: 1.211-1.697), MAE of 0.895 (95% CI: 0.818-0.981) and R(2) of 0.902 (95% CI: 0.882-0.918). In the SHAP analysis, the top 5 modifiable features at the population level were: level of health literacy, recognize self-weight status correctly, sedentariness duration on weekends, participation in professional sports training, frequency of staying up late. CONCLUSION: This study developed a BMI prediction model for adolescents using readily accessible daily information. The model accurately predicts BMI values 1 year later and provides both population-level and individual-level interpretability. Compared to existing studies, it offers key advantages, including independence from complex clinical data, the ability to predict continuous BMI values, and strong model interpretability. Our findings provide a promising research tool for screening high-risk adolescents, informing public health prevention and intervention strategies, and supporting personalized clinical interventions. CI - Copyright (c) 2025 Zhang, Peng, Sun, Zhang, Sun and Huang. FAU - Zhang, Zikang AU - Zhang Z AD - Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China. AD - University of Science and Technology of China, Hefei, Anhui, China. FAU - Peng, Wei AU - Peng W AD - Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China. AD - CAS Hefei Institute of Technology Innovation, Hefei, Anhui, China. FAU - Sun, Shaoming AU - Sun S AD - Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China. AD - CAS Hefei Institute of Technology Innovation, Hefei, Anhui, China. FAU - Zhang, Fangwen AU - Zhang F AD - Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China. AD - University of Science and Technology of China, Hefei, Anhui, China. FAU - Sun, Yining AU - Sun Y AD - Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China. FAU - Huang, Lei AU - Huang L AD - Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, China. AD - University of Science and Technology of China, Hefei, Anhui, China. LA - eng PT - Journal Article DEP - 20251120 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 RN - Chinese people SB - IM MH - Humans MH - *Body Mass Index MH - Adolescent MH - Prospective Studies MH - Female MH - Male MH - *Machine Learning MH - China MH - Surveys and Questionnaires MH - East Asian People PMC - PMC12675250 OTO - NOTNLM OT - BMI OT - daily information OT - machine learning OT - model interpretation OT - modifiable factors OT - prediction model COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/08 13:20 MHDA- 2025/12/08 13:21 PMCR- 2025/11/20 CRDT- 2025/12/08 06:29 PHST- 2025/07/01 00:00 [received] PHST- 2025/10/26 00:00 [revised] PHST- 2025/11/10 00:00 [accepted] PHST- 2025/12/08 13:21 [medline] PHST- 2025/12/08 13:20 [pubmed] PHST- 2025/12/08 06:29 [entrez] PHST- 2025/11/20 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1657551 [doi] PST - epublish SO - Front Public Health. 2025 Nov 20;13:1657551. doi: 10.3389/fpubh.2025.1657551. eCollection 2025. PMID- 41358216 OWN - NLM STAT- MEDLINE DCOM- 20251208 LR - 20251210 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Random forest-based identification and ranking of predictive factors for physical activity in Chinese college students. PG - 1699606 LID - 10.3389/fpubh.2025.1699606 [doi] LID - 1699606 AB - OBJECTIVE: To explore the key predictors of physical activity (PA) levels of Chinese university students, and to analyse the predictive roles of different variables and their relative importance by means of the Random Forest (RF) algorithm. METHODS: A cross-sectional study was conducted using a stratified whole-group sampling method, covering 17 provinces of the country and collecting 10,182 valid questionnaires. Assessment of PA levels using the Physical Activity Rating Scale-3 (PARS-3) divides participants into attainment and non-attainment groups. The independent variables encompass the individual and interpersonal organisational levels of the socio-ecological model (SEM), comprising a total of 39 variables. These variables include demographic characteristics, psycho-behavioural factors, and social support, which were measured using several standardised scales. Feature importance analysis was performed using the Random Forest algorithm, and the model parameters were optimised with a grid search and 5-fold cross-validation to identify the most significant factors predicting PA. RESULTS: The RF model had an accuracy of 0.704 and an AUC value of 0.762. Characteristic importance analysis revealed that exercise adherence (exercise behaviour), sex, exercise adherence (effort investment), mastery of sports skills, exercise motivation (ability), alcohol consumption level, exercise adherence [emotional experience, exercise motivation (social), and exercise motivation (fun) ranked as the top nine predictive factors]. Specifically, all sub-dimensions of exercise adherence (exercise behaviour) positively predict PA (SHAP values > 0); sex, males are more likely than females to meet the standard group criteria (OR > 1, p < 0.001); mastery of sports skills correlates positively with PA levels; and among alcohol consumption level, 'occasional drinking' shows a negative correlation with the standard attainment rate (p < 0.001). CONCLUSION: Exercise adherence, sex, mastery of sports skills, and alcohol consumption level are significant factors predicting PA levels among Chinese university students. Recommendations for promoting PA include enhancing the "emotional value" and social attributes of exercise, addressing female students' willingness to participate, and improving physical capabilities through skills training to effectively elevate activity levels. CI - Copyright (c) 2025 Zhang, Lou, Liu and Li. FAU - Zhang, Ding-You AU - Zhang DY AD - Institute of Sports Science, Nantong University, Nantong, China. FAU - Lou, Hu AU - Lou H AD - Institute of Sports Science, Nantong University, Nantong, China. FAU - Liu, Jun AU - Liu J AD - Institute of Sports Science, Nantong University, Nantong, China. FAU - Li, Bo AU - Li B AD - Institute of Sports Science, Nantong University, Nantong, China. LA - eng PT - Journal Article DEP - 20251120 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - Male MH - *Students/statistics & numerical data/psychology MH - Cross-Sectional Studies MH - *Exercise/psychology MH - China MH - Universities MH - Young Adult MH - Surveys and Questionnaires MH - Adult MH - Motivation MH - Adolescent MH - Algorithms MH - Social Support MH - Random Forest PMC - PMC12675355 OTO - NOTNLM OT - machine learning OT - physical activity OT - random forest OT - socio-ecological model OT - university students COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/08 13:19 MHDA- 2025/12/08 13:20 PMCR- 2025/11/20 CRDT- 2025/12/08 06:29 PHST- 2025/09/11 00:00 [received] PHST- 2025/11/06 00:00 [revised] PHST- 2025/11/07 00:00 [accepted] PHST- 2025/12/08 13:20 [medline] PHST- 2025/12/08 13:19 [pubmed] PHST- 2025/12/08 06:29 [entrez] PHST- 2025/11/20 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1699606 [doi] PST - epublish SO - Front Public Health. 2025 Nov 20;13:1699606. doi: 10.3389/fpubh.2025.1699606. eCollection 2025. PMID- 41358209 OWN - NLM STAT- MEDLINE DCOM- 20251208 LR - 20251210 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Early health education and cognitive inhibitory control in children: a 20-year pilot study using the go/no-go task in Japan. PG - 1703017 LID - 10.3389/fpubh.2025.1703017 [doi] LID - 1703017 AB - Extending healthy life expectancy requires attention not only to physical fitness but also to the development of cognitive self-regulation skills during childhood, which play a critical role in establishing lifelong health behaviors. Early health education has traditionally emphasized physical activity and lifestyle, yet cognitive aspects of self-control and inhibitory processes have received comparatively little attention. Inhibitory control is a central component of executive function, enabling children to regulate impulses, follow rules, and adapt to changing environments. Deficits in this capacity are associated with academic challenges, risk-taking behaviors, and poorer health outcomes later in life. Thus, incorporating assessments of cognitive inhibitory control into early health education may provide valuable insights for both educational and preventive health strategies. This pilot longitudinal study examined the feasibility of using the go/no-go task to assess inhibitory control in children aged 3-14 years in Nagano Prefecture, Japan. Assessments were conducted in 1998, 2008, and 2018, enabling exploration of changes over two decades. The task included three phases-formation, differentiation, and reverse differentiation-allowing for evaluation of both reaction times and error rates as indicators of speed-accuracy trade-offs in inhibitory performance. Results showed that children in 2018 exhibited significantly shorter reaction times but higher error rates compared with those assessed in 2008, suggesting a shift toward prioritizing speed over accuracy. These changes may reflect broader environmental and behavioral influences, such as increased exposure to digital devices, altered patterns of daily activity, or evolving educational contexts. Importantly, these findings indicate that inhibitory control, as captured by a simple cognitive paradigm, can reveal population-level shifts in child development over time. Incorporating cognitive tasks such as the go/no-go paradigm alongside conventional physical fitness testing in school-based health education may therefore enrich understanding of children's self-regulatory capacity. This approach has the potential to strengthen early identification of cognitive and behavioral trends, support tailored educational interventions, and inform broader community health promotion programs. By linking cognitive development with public health practice, it may contribute to strategies aimed at extending healthy life expectancy across the lifespan. CI - Copyright (c) 2025 Watanabe, Kamijo, Ashida, Sasamori, Okuhara, Maruo, Tabuchi and Terasawa. FAU - Watanabe, Noriaki AU - Watanabe N AD - Graduate School of Medicine, Science and Technology, Shinshu University, Ueda, Japan. FAU - Kamijo, Masayoshi AU - Kamijo M AD - Graduate School of Medicine, Science and Technology, Shinshu University, Ueda, Japan. FAU - Ashida, Kazuki AU - Ashida K AD - National Institute of Technology, Nagano College, Nagano, Japan. FAU - Sasamori, Fumihito AU - Sasamori F AD - Faculty of Engineering, Shinshu University, Nagano, Japan. FAU - Okuhara, Masao AU - Okuhara M AD - Department of Applied Information Engineering, Faculty of Engineering, Suwa University of Science, Chino, Japan. FAU - Maruo, Suchinda Jarupat AU - Maruo SJ AD - Department of Occupational Health and Safety, Faculty of Public Health, Mahidol University, Bangkok, Thailand. FAU - Tabuchi, Hisaaki AU - Tabuchi H AD - Department of Psychology, University of Innsbruck, Innsbruck, Austria. FAU - Terasawa, Koji AU - Terasawa K AD - Graduate School of Medicine, Shinshu University, Matsumoto, Japan. LA - eng PT - Journal Article DEP - 20251120 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Pilot Projects MH - Child MH - Male MH - Female MH - Japan MH - *Cognition/physiology MH - Longitudinal Studies MH - Adolescent MH - Child, Preschool MH - *Health Education MH - *Inhibition, Psychological MH - *Executive Function/physiology MH - Reaction Time MH - Self-Control PMC - PMC12675476 OTO - NOTNLM OT - children OT - cognitive inhibitory control OT - early health education OT - go/no-go task OT - health behavior COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/08 13:20 MHDA- 2025/12/08 13:21 PMCR- 2025/11/20 CRDT- 2025/12/08 06:29 PHST- 2025/09/10 00:00 [received] PHST- 2025/10/23 00:00 [accepted] PHST- 2025/12/08 13:21 [medline] PHST- 2025/12/08 13:20 [pubmed] PHST- 2025/12/08 06:29 [entrez] PHST- 2025/11/20 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1703017 [doi] PST - epublish SO - Front Public Health. 2025 Nov 20;13:1703017. doi: 10.3389/fpubh.2025.1703017. eCollection 2025. PMID- 41357513 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251208 LR - 20251210 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 12 DP - 2025 TI - Advancements in pediatric obstructive sleep apnea: cognitive implications and the role of AI in precision medicine. PG - 1704504 LID - 10.3389/fmed.2025.1704504 [doi] LID - 1704504 AB - BACKGROUND: Obstructive sleep apnea (OSA) in children is linked to cognitive impairment, which is further aggravated by fragmented sleep, intermittent hypoxia, and comorbid attention deficit hyperactivity disorder (ADHD), often resulting in poor academic performance, behavioral problems, and delayed neurodevelopment. METHODS: A bibliometric and scientometric analysis was conducted using Web of Science Core Collection (WoSCC) and Scopus databases (1983-2025). After exclusion of non-article records and duplicates, 1,610 studies were included. CiteSpace, VOSviewer, and the R-based Bibliometrix package were employed to analyze publication trends, authorship, institutional collaborations, co-citations, and keyword evolution. RESULTS: Since 2010, scholarly attention to pediatric obstructive sleep apnea and its cognitive implications has grown rapidly, with research output increasing at an annual rate of 11.96%. The United States, China, and several European countries stand out as major contributors, both in terms of publications and international collaboration. Prominent academic centers-such as Harvard University, the University of Michigan, and the University of Chicago-serve as key institutional hubs. Among the most influential contributors to the field are David Gozal and Leila Kheirandish-Gozal, while leading journals include Sleep Medicine and the Journal of Clinical Sleep Medicine. Keyword mapping highlights the central focus on "obstructive sleep apnea," "children," and "sleep-disordered breathing," alongside diagnostic and treatment terms such as "polysomnography" and "adenotonsillectomy." Notably, there is growing emphasis on cognitive and behavioral aspects, including "cognition," "behavior," and "ADHD," as well as comorbidities like "obesity" and "Down syndrome." Recent clusters underscore advances in artificial intelligence (AI) and machine learning (ML) based models using oximetry, electrocardiogram (ECG), and acoustic data, enabling early detection and supporting precision medicine approaches. CONCLUSION: The relationship between pediatric obstructive sleep apnea and neurocognitive development has gained significant attention, with recent research focusing on cognitive outcomes and emerging technologies. While conventional treatments remain important, their limited impact on cognitive recovery underscores the need for early diagnosis and personalized therapies. Advances in artificial intelligence and machine learning are improving diagnostic accuracy, enabling earlier interventions, and supporting neurocognitive function in affected children. These developments reflect a shift toward precision-based, tailored care rather than one-size-fits-all treatments. CI - Copyright (c) 2025 Zhao, Fan, Niu, Li, Deng, Zhai, Wang and Gao. FAU - Zhao, Bomeng AU - Zhao B AD - The Second Hospital of Shanxi Medical University, Taiyuan, China. FAU - Fan, Haixia AU - Fan H AD - First Hospital of Shanxi Medical University, Taiyuan, China. FAU - Niu, Huiyan AU - Niu H AD - The Second Hospital of Shanxi Medical University, Taiyuan, China. FAU - Li, Yan AU - Li Y AD - The Second Hospital of Shanxi Medical University, Taiyuan, China. FAU - Deng, Shudan AU - Deng S AD - The Second Hospital of Shanxi Medical University, Taiyuan, China. FAU - Zhai, Lu AU - Zhai L AD - The Second Hospital of Shanxi Medical University, Taiyuan, China. FAU - Wang, Limantian AU - Wang L AD - The Second Hospital of Shanxi Medical University, Taiyuan, China. FAU - Gao, Xiaoling AU - Gao X AD - Department of Sleep Center, The Second Hospital of Shanxi Medical University Taiyuan, Taiyuan, China. LA - eng PT - Journal Article PT - Systematic Review DEP - 20251121 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC12678086 OTO - NOTNLM OT - artificial intelligence OT - bibliometric analysis OT - cognition OT - pediatric obstructive sleep apnea OT - precision medicine COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/08 13:19 MHDA- 2025/12/08 13:20 PMCR- 2025/11/21 CRDT- 2025/12/08 06:21 PHST- 2025/09/13 00:00 [received] PHST- 2025/11/03 00:00 [accepted] PHST- 2025/12/08 13:20 [medline] PHST- 2025/12/08 13:19 [pubmed] PHST- 2025/12/08 06:21 [entrez] PHST- 2025/11/21 00:00 [pmc-release] AID - 10.3389/fmed.2025.1704504 [doi] PST - epublish SO - Front Med (Lausanne). 2025 Nov 21;12:1704504. doi: 10.3389/fmed.2025.1704504. eCollection 2025. PMID- 41356815 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251208 LR - 20251210 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Balancing trade-offs between nutritional quality, consumer acceptability and climate impact across a spectrum of chili con carne formulations: from plant-based to hybrid. PG - 1716322 LID - 10.3389/fnut.2025.1716322 [doi] LID - 1716322 AB - INTRODUCTION: Transitioning to sustainable food consumption, through nutritious and low carbon diets, is essential to address climate and health challenges. Current trends indicate an increase of plant-based meals in schools. However, these climate-friendly options are not consistently well-received by students and often fail to meet dietary iron requirements, particularly for adolescent girls. This study aims to develop a methodology for creating sustainable school meal recipes that balance absorbable iron, carbon footprint, and taste preferences. METHODS: The methodology involves iterative recipe development, including cooking elaborations and consumer evaluations. A chili con carne recipe was selected as the test dish where various plant-based and meat hybrid alternatives were assessed. Absorbable iron was calculated using the Hallberg and Hulthen algorithm, factoring in inhibitors and enhancers. Consumer evaluations were conducted in two rounds with university staff and students as a methodological validation step, involving sensory assessments and preference tests. RESULTS: The study found substantial differences between total iron content and absorbable iron, with plant-based recipes (Soy1) achieving only 35% of the required absorbable iron for high-need teenage girls despite meeting total iron requirements. Hybrid recipes incorporating both meat and plant-based ingredients showed better iron bioavailability and were more acceptable to consumers. Optimized recipes reduced carbon footprint by 16-84% compared to the original recipe, with hybrid recipes (Beef/Soy and Beef/Lentils) achieving 37-39% reductions while maintaining adequate absorbable iron levels (0.42-0.56 mg per meal vs. 0.44-0.66 mg target range). DISCUSSION/CONCLUSION: The findings suggest that hybrid recipes can effectively balance absorbable iron, carbon footprint and taste preferences to promote sustainable and healthy eating habits among adolescents. Validation with the target adolescent population in school settings is recommended as the essential next step. CI - Copyright (c) 2025 Wollmar, Post, Elf, Ingridsdotter, Prim and Sjoberg. FAU - Wollmar, Mari AU - Wollmar M AD - Department of Food and Nutrition and Sport Science, University of Gothenburg, Gothenburg, Sweden. FAU - Post, Anna AU - Post A AD - Department of Food and Nutrition and Sport Science, University of Gothenburg, Gothenburg, Sweden. FAU - Elf, Maja AU - Elf M AD - Department of Food and Nutrition and Sport Science, University of Gothenburg, Gothenburg, Sweden. FAU - Ingridsdotter, Josephine AU - Ingridsdotter J AD - Department of Food and Nutrition and Sport Science, University of Gothenburg, Gothenburg, Sweden. FAU - Prim, Mia AU - Prim M AD - Department of Food and Nutrition and Sport Science, University of Gothenburg, Gothenburg, Sweden. FAU - Sjoberg, Agneta AU - Sjoberg A AD - Department of Food and Nutrition and Sport Science, University of Gothenburg, Gothenburg, Sweden. LA - eng PT - Journal Article DEP - 20251121 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12678115 OTO - NOTNLM OT - absorbable iron OT - meal development OT - plant-based OT - sustainable public meals OT - taste COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/08 13:20 MHDA- 2025/12/08 13:21 PMCR- 2025/11/21 CRDT- 2025/12/08 06:15 PHST- 2025/09/30 00:00 [received] PHST- 2025/10/30 00:00 [accepted] PHST- 2025/12/08 13:21 [medline] PHST- 2025/12/08 13:20 [pubmed] PHST- 2025/12/08 06:15 [entrez] PHST- 2025/11/21 00:00 [pmc-release] AID - 10.3389/fnut.2025.1716322 [doi] PST - epublish SO - Front Nutr. 2025 Nov 21;12:1716322. doi: 10.3389/fnut.2025.1716322. eCollection 2025. PMID- 41356680 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251208 LR - 20251210 IS - 1664-0640 (Print) IS - 1664-0640 (Electronic) IS - 1664-0640 (Linking) VI - 16 DP - 2025 TI - Acupuncture enhances fatty acid catabolism and immune modulation in children with autism. PG - 1679154 LID - 10.3389/fpsyt.2025.1679154 [doi] LID - 1679154 AB - Autism spectrum disorder (ASD) is a heterogeneous neurodevelopmental condition with limited effective therapies targeting its underlying biological mechanisms. Acupuncture has shown clinical promise in improving core ASD symptoms, yet its molecular effects remain poorly understood. This study aimed to investigate the systemic mechanisms by which acupuncture exerts therapeutic effects in ASD, using an integrated plasma-based proteomic and metabolomic approach. Twenty children were enrolled, including 10 diagnosed with ASD and 10 age- and sex-matched typically developing controls. The ASD group received a 12-week standardized acupuncture intervention. Plasma samples were collected before and after treatment, and analyzed using data-independent acquisition-based LC-MS/MS for proteomics and high-resolution mass spectrometry for metabolomics. Differentially expressed proteins and metabolites were identified across healthy controls, pre-treatment, and post-treatment ASD groups, followed by pathway enrichment and integrated network analysis. Acupuncture significantly modulated biological pathways related to immune regulation, mitochondrial oxidative phosphorylation, glycolysis, folate biosynthesis, lipid metabolism, and fatty acid degradation. Notable differentially expressed proteins included CD59 and CD5L, ATP5F1A and ALDOC, and HYAL1. Metabolomic profiling revealed altered levels of lipids, lipid-like molecules, benzenoids, and folate-related metabolites, implicating changes in neurochemical balance and detoxification capacity. Fatty acid degradation pathways were also enhanced, suggesting a systemic metabolic shift toward an anti-inflammatory state. Integrating proteomic and metabolomic data, the results support a multi-system mechanism through which acupuncture restores immune-metabolic homeostasis, consistent with the holistic therapeutic framework of traditional Chinese medicine. The identification of candidate biomarkers such as CD59, ATP5F1A, and ALDOC offers potential tools for therapeutic monitoring and mechanistic insight. This study presents the first multi-omics evidence for the biological basis of acupuncture in ASD and provides a rationale for individualized interventions. These findings support future research integrating acupuncture with metabolic, nutritional, or immunological therapies. Larger-scale, controlled trials with functional validation of molecular targets are warranted to confirm these findings and guide clinical translation. CLINICAL TRIAL REGISTRATION: https://itmctr.ccebtcm.org.cn/mgt/project/view/896756278374891597/, identifier ITMCTR2025000067. CI - Copyright (c) 2025 Xu and Bao. FAU - Xu, Jinbo AU - Xu J AD - The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. AD - Anhui Provincial Children's Hospital, Hefei, China. FAU - Bao, Chao AU - Bao C AD - The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China. LA - eng PT - Journal Article DEP - 20251120 PL - Switzerland TA - Front Psychiatry JT - Frontiers in psychiatry JID - 101545006 PMC - PMC12675399 OTO - NOTNLM OT - acupuncture OT - autism spectrum disorder OT - metabolomics OT - plasma OT - proteomics COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/08 13:18 MHDA- 2025/12/08 13:19 PMCR- 2025/11/20 CRDT- 2025/12/08 06:13 PHST- 2025/08/04 00:00 [received] PHST- 2025/10/29 00:00 [revised] PHST- 2025/11/05 00:00 [accepted] PHST- 2025/12/08 13:19 [medline] PHST- 2025/12/08 13:18 [pubmed] PHST- 2025/12/08 06:13 [entrez] PHST- 2025/11/20 00:00 [pmc-release] AID - 10.3389/fpsyt.2025.1679154 [doi] PST - epublish SO - Front Psychiatry. 2025 Nov 20;16:1679154. doi: 10.3389/fpsyt.2025.1679154. eCollection 2025. PMID- 41356126 OWN - NLM STAT- MEDLINE DCOM- 20251208 LR - 20251210 IS - 1937-8688 (Electronic) VI - 52 DP - 2025 TI - Tumor size, TIRADS, and lymph node status as predictors of central neck dissection in thyroid cancer. PG - 39 LID - 10.11604/pamj.2025.52.39.48016 [doi] LID - 39 AB - INTRODUCTION: the aim was to evaluate the predictive value of tumor size, TIRADS classification, lymph node involvement, and demographic factors in guiding central neck dissection (CND) in patients with thyroid cancer. METHODS: this retrospective cross-sectional study included 437 patients, selected through convenience sampling, who underwent total thyroidectomy for thyroid cancer at a tertiary hospital in Riyadh, Saudi Arabia, from 2010 to 2023. Data collected included age, sex, BMI, tumor size, TIRADS level, lymph node status, and fine-needle aspiration (FNA) results. Associations with the performance of CND were analyzed using Pearson correlation coefficients and descriptive statistics. RESULTS: lymph node involvement, defined as histopathologically confirmed central lymph node metastasis, was the strongest independent predictor of CND (r = 0.5285, p < 0.0001), followed by tumor size (r = 0.4200, p < 0.0001) and TIRADS score (r = 0.2128, p = 0.0467). Age showed a weak but statistically significant association with CND (r = 0.1426, p = 0.0031), while sex and BMI had no significant impact. The majority of nodules were classified as TIRADS 3 to 5 (87.17%), and patients undergoing CND tended to be older with larger tumors and higher TIRADS categories. CONCLUSION: lymph node involvement, tumor size, and TIRADS classification are meaningful predictors of surgical management in thyroid cancer. Integrating these factors into preoperative evaluation supports a personalized approach to CND, potentially reducing unnecessary procedures and improving patient outcomes. These findings support the development of standardized, risk-adapted surgical criteria for central neck dissection in thyroid cancer. CI - Copyright: Mohammed Al-Essa et al. FAU - Al-Essa, Mohammed AU - Al-Essa M AD - Department of Otolaryngology-Head and Neck Surgery, College of Medicine, King Saud University, Riyadh, Saudi Arabia. LA - eng PT - Journal Article DEP - 20250925 PL - Uganda TA - Pan Afr Med J JT - The Pan African medical journal JID - 101517926 SB - IM MH - Humans MH - Male MH - Female MH - *Thyroid Neoplasms/pathology/surgery MH - Retrospective Studies MH - *Neck Dissection/methods MH - Middle Aged MH - Saudi Arabia MH - Cross-Sectional Studies MH - Adult MH - *Thyroidectomy/methods MH - Lymphatic Metastasis MH - Biopsy, Fine-Needle MH - Aged MH - Young Adult MH - *Lymph Nodes/pathology MH - Age Factors MH - Predictive Value of Tests MH - Tumor Burden MH - Adolescent MH - Tertiary Care Centers PMC - PMC12676277 OTO - NOTNLM OT - TIRADS OT - Thyroid cancer OT - central neck dissection OT - lymph node metastasis OT - tumor size COIS- The author declares no competing interests. EDAT- 2025/12/08 13:19 MHDA- 2025/12/08 13:20 PMCR- 2025/09/25 CRDT- 2025/12/08 06:08 PHST- 2025/05/19 00:00 [received] PHST- 2025/09/06 00:00 [accepted] PHST- 2025/12/08 13:20 [medline] PHST- 2025/12/08 13:19 [pubmed] PHST- 2025/12/08 06:08 [entrez] PHST- 2025/09/25 00:00 [pmc-release] AID - PAMJ-52-39 [pii] AID - 10.11604/pamj.2025.52.39.48016 [doi] PST - epublish SO - Pan Afr Med J. 2025 Sep 25;52:39. doi: 10.11604/pamj.2025.52.39.48016. eCollection 2025. PMID- 41355796 OWN - NLM STAT- MEDLINE DCOM- 20251208 LR - 20260717 IS - 2379-3708 (Electronic) IS - 2379-3708 (Linking) VI - 10 IP - 23 DP - 2025 Dec 8 TI - A transcriptomic signature that predicts prehypertension in adolescence and higher systolic blood pressure in childhood. LID - 10.1172/jci.insight.192837 [doi] LID - e192837 AB - BACKGROUNDSuboptimal fetal growth (SFG), being born small for gestational age (SGA), and catch-up (CU) growth are, individually and together, linked to cardiometabolic risks. However, not all develop adverse outcomes. This study aimed to validate a transcriptomic signature to identify individuals at greatest cardiometabolic risk.METHODSUsing National Heart, Lung and Blood Institute (NHLBI) criteria to define cardiometabolic risk, healthy and prehypertensive 17-year-olds were identified in the Avon Longitudinal Study of Parents and Children (ALSPAC) (UK) childhood cohort. Epigenomic and transcriptomic differences were analyzed. A hypergraph identified functionally related genes, which were used in random forest classification to predict prehypertensive phenotypes. The BabyGRO (UK) cohort included 80 children aged 3-7 years, born at term following pregnancies with SFG risks. Anthropometric and cardiometabolic markers and transcriptomic profiles were collected, fetal and childhood weight trajectories and their relationship to cardiometabolic markers were assessed, and transcriptome was used for prediction.RESULTSIndividuals with CU-SGA in ALSPAC were 1.6 times more likely than all others to be prehypertensive at 17 years (P < 1 x 10-5). A 42-gene hypergraph cluster was highly predictive of prehypertension (AUC 0.984, error rate 5.4%). In BabyGRO, 20 of these genes accurately predicted higher systolic blood pressure (AUC 0.971, error rate 3.6%). This transcriptomic signature could help identify children with adverse pre- and postnatal growth who may develop prehypertension.CONCLUSIONA blood transcriptomic signature exists in childhood which distinguishes those at risk of adult cardiometabolic disease among children with adverse pre- and postnatal growth.TRIAL REGISTRATIONRegional ethics committee reference 17/NW/0153, IRAS project ID 187679.FUNDINGCentre grant to the Maternal and Fetal Health Research Centre by Tommy's The Pregnancy and Baby Charity, Child Growth Foundation, European Research Council funding as part of the Health and Environment-wide Associations based on Large Population Surveys (HEALS) study. FAU - Perchard, Reena AU - Perchard R AD - Division of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom. AD - Manchester University NHS Foundation Trust, Manchester, United Kingdom. FAU - Garner, Terence AU - Garner T AD - Division of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom. FAU - Murray, Philip G AU - Murray PG AD - Manchester University NHS Foundation Trust, Manchester, United Kingdom. FAU - Roslan, Amirul AU - Roslan A AD - Division of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom. FAU - Higgins, Lucy E AU - Higgins LE AD - Division of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom. AD - Manchester University NHS Foundation Trust, Manchester, United Kingdom. FAU - Johnstone, Edward D AU - Johnstone ED AD - Division of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom. AD - Manchester University NHS Foundation Trust, Manchester, United Kingdom. FAU - Stevens, Adam AU - Stevens A AD - Division of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom. FAU - Clayton, Peter E AU - Clayton PE AD - Division of Developmental Biology & Medicine, Faculty of Biology, Medicine & Health, University of Manchester, Manchester, United Kingdom. LA - eng PT - Journal Article PT - Research Support, N.I.H., Extramural DEP - 20251208 PL - United States TA - JCI Insight JT - JCI insight JID - 101676073 SB - IM MH - Humans MH - *Prehypertension/genetics/diagnosis/epidemiology MH - Female MH - Male MH - Adolescent MH - Child MH - *Transcriptome MH - Child, Preschool MH - *Blood Pressure/genetics MH - Longitudinal Studies MH - Infant, Small for Gestational Age MH - Fetal Development/genetics MH - Pregnancy PMC - PMC12890495 OTO - NOTNLM OT - Cardiology OT - Hypertension OT - Preventative medicine OT - Public Health EDAT- 2025/12/08 13:19 MHDA- 2025/12/08 13:20 PMCR- 2025/12/08 CRDT- 2025/12/08 06:03 PHST- 2025/03/03 00:00 [received] PHST- 2025/10/22 00:00 [accepted] PHST- 2025/12/08 13:20 [medline] PHST- 2025/12/08 13:19 [pubmed] PHST- 2025/12/08 06:03 [entrez] PHST- 2025/12/08 00:00 [pmc-release] AID - 192837 [pii] AID - 10.1172/jci.insight.192837 [doi] PST - epublish SO - JCI Insight. 2025 Dec 8;10(23):e192837. doi: 10.1172/jci.insight.192837. eCollection 2025 Dec 8. PMID- 41355391 OWN - NLM STAT- MEDLINE DCOM- 20260130 LR - 20260916 IS - 1531-5487 (Electronic) IS - 1044-3983 (Print) IS - 1044-3983 (Linking) VI - 37 IP - 2 DP - 2026 Mar 1 TI - Comparison of Lactation Information from Electronic Health Records with Survey Data Across Five US Health Systems. PG - 198-206 LID - 10.1097/EDE.0000000000001931 [doi] AB - BACKGROUND: Data on lactation status for research are often collected through surveys. Information on human milk feeding collected at routine healthcare visits and stored in electronic health records (EHR) is an emerging source of data for lactation research. We compared information on milk feeding obtained from structured EHR fields with survey data. METHODS: We included participants from five US healthcare systems in the Managing Our Mood survey. Individuals had a live birth (March 2022-October 2023), depression diagnosis during pregnancy, and >/=1 record of human milk feeding information in their or their infant's EHR. We compared information from EHR data up to ten months after delivery with survey data collected 3-4 months after delivery as the reference. We assessed agreement on lactation status (human milk feeding ever and at survey) using percent agreement, Cohen's kappa, sensitivity, specificity, positive predictive value, and negative predictive value overall and by characteristics. RESULTS: According to survey data, the prevalence of human milk feeding ever was 93.2% and was 73.0% at the time of survey among 281 eligible individuals. Agreement between data sources for ever and for human milk feeding at the survey was >/=92% with kappas >/=0.77. EHR and survey data agreed on human milk feeding ever for 97.3% (95% confidence interval: 94.6%, 98.7%) and on human milk feeding at the time of the survey for 98.0% (95% confidence interval: 95.1%, 99.2%) of those who reported yes to these practices on the survey. These measurements were lower among individuals with fewer records. CONCLUSIONS: There was substantial agreement on lactation status between EHR and survey data. These findings suggest that lactation information from structured EHR may be used for epidemiologic research. CI - Copyright (c) 2025 Wolters Kluwer Health, Inc. All rights reserved. FAU - Jansen, Gregory P AU - Jansen GP AD - From the Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN. FAU - Seburg, Elisabeth M AU - Seburg EM AD - Pregnancy and Child Health Research Center, HealthPartners Institute, Minneapolis, MN. FAU - Vazquez-Benitez, Gabriela AU - Vazquez-Benitez G AD - Pregnancy and Child Health Research Center, HealthPartners Institute, Minneapolis, MN. FAU - Ehresmann, Kirsten AU - Ehresmann K AD - Pregnancy and Child Health Research Center, HealthPartners Institute, Minneapolis, MN. FAU - Mohamed, Hibo H AU - Mohamed HH AD - Pregnancy and Child Health Research Center, HealthPartners Institute, Minneapolis, MN. FAU - Avalos, Lyndsay A AU - Avalos LA AD - Division of Research, Kaiser Permanente Northern California, Oakland, CA. AD - Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA. FAU - Negriff, Sonya AU - Negriff S AD - Kaiser Permanente Bernard J. Tyson School of Medicine, Pasadena, CA. AD - Department of Research and Evaluation, Kaiser Permanente Southern California, Pasadena, CA. FAU - Loree, Amy M AU - Loree AM AD - Center for Health Policy & Health Services Research, Henry Ford Health, Detroit, MI. FAU - Howick, Connor K AU - Howick CK AD - Center for Integrated Health Care Research, Kaiser Permanente Hawaii, Honolulu, HI. FAU - Daida, Yihe G AU - Daida YG AD - Center for Integrated Health Care Research, Kaiser Permanente Hawaii, Honolulu, HI. FAU - Palmsten, Kristin AU - Palmsten K AUID- ORCID: 0000-0002-0134-6228 AD - Pregnancy and Child Health Research Center, HealthPartners Institute, Minneapolis, MN. LA - eng GR - R01 HD100579/HD/NICHD NIH HHS/United States GR - R01 HD107753/HD/NICHD NIH HHS/United States PT - Comparative Study PT - Journal Article DEP - 20260129 PL - United States TA - Epidemiology JT - Epidemiology (Cambridge, Mass.) JID - 9009644 SB - IM MH - Humans MH - *Electronic Health Records/statistics & numerical data MH - Female MH - *Lactation MH - *Breast Feeding/statistics & numerical data MH - Adult MH - United States/epidemiology MH - Surveys and Questionnaires MH - Pregnancy MH - Young Adult PMC - PMC13576411 MID - NIHMS2204941 OTO - NOTNLM OT - Breastfeeding OT - Electronic health records OT - Epidemiology OT - Human milk OT - Validation studies EDAT- 2025/12/08 06:27 MHDA- 2026/01/30 20:01 PMCR- 2026/09/15 CRDT- 2025/12/08 02:52 PHST- 2026/01/30 20:01 [medline] PHST- 2025/12/08 06:27 [pubmed] PHST- 2025/12/08 02:52 [entrez] PHST- 2026/09/15 00:00 [pmc-release] AID - 00001648-202603000-00006 [pii] AID - 10.1097/EDE.0000000000001931 [doi] PST - ppublish SO - Epidemiology. 2026 Mar 1;37(2):198-206. doi: 10.1097/EDE.0000000000001931. Epub 2026 Jan 29. PMID- 41355309 OWN - NLM STAT- MEDLINE DCOM- 20260420 LR - 20261008 IS - 2050-439X (Electronic) IS - 2050-4381 (Linking) VI - 14 IP - 6 DP - 2026 Apr TI - Optimisation of a sexual health and healthy relationships intervention for Further Education in England and Wales (SaFE). PG - 33-52 LID - 10.3310/AHDP8546 [doi] AB - BACKGROUND: Adverse sexual health, dating and relationship violence, and sexual harassment are significant public health concerns, especially among young people. Sexually transmitted infection rates are at a 10-year high, and dating and relationship violence affects nearly half of young people. Further education provides a population-wide setting for delivering dating and relationship violence and sexual health interventions, but only a few interventions have been shown to be effective in further education. OBJECTIVES: To optimise intervention materials and identify refinements for the Sexual Health and Healthy Relationships for further education (SaFE) intervention, an intervention to improve sexual health and reduce dating and relationship violence and sexual harassment among young people attending further education. Optimised materials were used in a pilot cluster randomised controlled trial of SaFE. SaFE had three components: (1) onsite access to sexual health and relationship services in further education settings provided by sexual health nurses for 2 hours, 2 days per week; (2) publicity about onsite services and (3) further education staff training on how to promote sexual health and recognise and respond to dating and relationship violence and sexual harassment. This paper reports on the optimisation of the SaFE intervention materials. DESIGN AND METHODS: A multistage iterative process was used to optimise further education staff training and publicity materials. This involved a series of consultation and focus group feedback sessions. SETTING AND PARTICIPANTS: In Stage 1, feedback was collected from the SaFE Trial Management Group. Stage 2 involved: (1) two focus groups; one with four further education staff and one with three further education students at one further education institution and (2) stakeholder consultation with seven experts. Stage 3 saw consultation with the Trial Steering Committee who had independent oversight of the study. The operational feasibility of the training was evaluated in Stage 4 through a trial run with further education safeguarding and well-being teams. Stage 5 comprised a final review of intervention material by the Trial Management Group. Stage 6 gained online feedback from a young people's advisory group. The study was conducted in England and Wales. RESULTS: In Stage 1, Trial Management Group reviewers recommended improving clarity and factual accuracy, reducing the length of slide decks and adding content on sending explicit images. Stage 2 feedback from further education staff and students focused on training content addressing comprehensiveness, structure and visual design and training delivery addressing preferred training formats and opportunities for scenario-based learning. The Trial Steering Committee in Stage 3 advised on managing participant disclosures and reordering content. Stage 4's trial run with further education staff identified redundancy in content, the incorporation of task-based exercises and varied learning approaches. Stage 5's Trial Management Group review led to the integration of multimedia elements and case studies. Stage 6 feedback from young people improved clarity and accessibility in publicity materials. LIMITATIONS: Low participation and self-selection in focus groups may limit the generalisability of the findings. The move to online engagement during COVID-19 may have hindered the depth of interaction. Recruiting from a single institution could introduce sampling bias. CONCLUSIONS: Fully optimised staff training and publicity materials were produced that were considered acceptable and consistent with the theory of change as agreed by the research team, Trial Steering Committee, stakeholder advisory group and further education students staff and young people. FUTURE WORK: After the optimisation phase, the SaFE intervention was delivered in a pilot cluster randomised controlled trial with high fidelity to six further education settings in England and Wales. Future work could explore strategies to evaluate the effectiveness as well as improve scalability and sustainability of interventions like SaFE. FUNDING: This article presents independent research funded by the National Institute for Health and Care Research (NIHR) Public Health Research programme as award number 17/149/12. FAU - Aslam, Rabeea'h Waseem AU - Aslam RW AUID- ORCID: 0000-0002-0916-9641 AD - Centre for the Development, Evaluation, Complexity and Implementation in Public Health Improvement, Cardiff University, Cardiff, UK. FAU - Williams-Thomas, Rhys AU - Williams-Thomas R AUID- ORCID: 0000-0002-1779-3460 AD - Cardiff University College of Biomedical and Life Sciences, Centre for Trials Research, Cardiff, UK. FAU - Townson, Julia AU - Townson J AUID- ORCID: 0000-0001-8679-3619 AD - Cardiff University College of Biomedical and Life Sciences, Centre for Trials Research, Cardiff, UK. FAU - Lewis, Ruth AU - Lewis R AUID- ORCID: 0000-0002-6768-6188 AD - MRC Social and Public Health Sciences Unit, University of Glasgow, Glasgow, UK. FAU - Madan, Jason AU - Madan J AUID- ORCID: 0000-0003-4316-1480 AD - Warwick Medical School, University of Warwick, Warwick, UK. FAU - Melendez-Torres, G J AU - Melendez-Torres GJ AUID- ORCID: 0000-0002-9823-4790 AD - Faculty of Health and Life Sciences, University of Exeter, Exeter, UK. FAU - Lugg-Widger, Fiona AU - Lugg-Widger F AUID- ORCID: 0000-0003-0029-9703 AD - Cardiff University College of Biomedical and Life Sciences, Centre for Trials Research, Cardiff, UK. FAU - Pallmann, Philip AU - Pallmann P AUID- ORCID: 0000-0001-8274-9696 AD - Cardiff University College of Biomedical and Life Sciences, Centre for Trials Research, Cardiff, UK. FAU - Brown, Rachel AU - Brown R AUID- ORCID: 0000-0002-4475-1733 AD - Centre for the Development, Evaluation, Complexity and Implementation in Public Health Improvement, Cardiff University, Cardiff, UK. FAU - Bonell, Chris AU - Bonell C AUID- ORCID: 0000-0002-6253-6498 AD - Department of Public Health, Environments and Society, London School of Hygiene & Tropical Medicine, London, UK. FAU - Morgan, Gemma S AU - Morgan GS AUID- ORCID: 0000-0003-2472-9309 AD - Public Health and Wellbeing Division, South Gloucestershire Council, Yate, UK. FAU - White, James AU - White J AUID- ORCID: 0000-0001-8371-8453 AD - Centre for the Development, Evaluation, Complexity and Implementation in Public Health Improvement, Cardiff University, Cardiff, UK. AD - Cardiff University College of Biomedical and Life Sciences, Centre for Trials Research, Cardiff, UK. FAU - Young, Honor AU - Young H AUID- ORCID: 0000-0003-0664-4002 AD - Centre for the Development, Evaluation, Complexity and Implementation in Public Health Improvement, Cardiff University, Cardiff, UK. LA - eng PT - Journal Article PT - Randomized Controlled Trial PL - England TA - Public Health Res (Southampt) JT - Public health research (Southampton, England) JID - 101653231 SB - IM MH - Humans MH - *Sexual Health/education MH - England MH - Female MH - Wales MH - Male MH - Adolescent MH - Young Adult MH - Pilot Projects MH - *Sexual Harassment/prevention & control MH - *Intimate Partner Violence/prevention & control MH - Adult OAB - Improving sexual health and reducing dating and relationship violence in young people is a public health priority. The Sexual Health and Healthy Relationships for Further Education (SaFE) intervention addresses these issues by providing onsite sexual health services in further education colleges, raising awareness about these services and training staff to promote sexual health and handle violence and harassment-related concerns. This study looked at what changes were needed to make sure that existing publicity and intervention materials are right for further education settings. To improve existing further education staff training to prevent dating and relationship violence and sexual harassment, we adapted existing training materials, collected feedback from a group of experts and conducted focus groups with further education staff and students in England and Wales. We also consulted with an expert oversight committee and delivered practice training. Next, we gathered feedback on publicity materials from a young people's advisory group. Across stages, feedback from experts, staff and young people found that further education staff training materials needed to be clearer and more engaging. Participants highlighted the importance of making the content accessible, reducing jargon and definitions, and providing examples relevant to practice on safeguarding and legal aspects of consent. Incorporating interactive elements and case studies made training more acceptable and engaging to participants. Following on from the optimisation stage of the research, we produced staff training and publicity materials that, in the opinion of the research team, oversight committee, stakeholder advisory group, along with further education students, staff and young people, were acceptable and consistent with the way in which the intervention is intended to work. SaFE was successfully tested in a pilot study across six further education settings in England and Wales. Future research could look at whether interventions like SaFE work at improving sexual health and reducing dating violence, as well as ways to make interventions like SaFE more scalable and sustainable for long-term impact. OABL- eng OTO - NOTNLM OT - EDUCATION OT - OPTIMISATION OT - PUBLICITY MATERIALS OT - SEXUAL HEALTH OT - SEXUALLY TRANSMITTED DISEASES OT - STAFF TRAINING OT - VIOLENCE OT - YOUNG PEOPLE EDAT- 2025/12/08 06:27 MHDA- 2026/04/21 17:49 CRDT- 2025/12/08 02:13 PHST- 2026/04/21 17:49 [medline] PHST- 2025/12/08 06:27 [pubmed] PHST- 2025/12/08 02:13 [entrez] AID - 10.3310/AHDP8546 [doi] PST - ppublish SO - Public Health Res (Southampt). 2026 Apr;14(6):33-52. doi: 10.3310/AHDP8546. PMID- 41353659 OWN - NLM STAT- MEDLINE DCOM- 20251229 LR - 20260516 IS - 1532-7914 (Electronic) IS - 0163-5581 (Linking) VI - 78 IP - 2 DP - 2026 TI - Adherence to Oral Nutritional Support and Its Effect on Nutritional Status in Pediatric Oncology Patients. PG - 145-157 LID - 10.1080/01635581.2025.2584473 [doi] AB - Children with cancer frequently suffer from malnutrition caused by their disease and treatments. This study examines the rates of malnutrition, compliance with nutritional therapy, and its impact on nutritional status in pediatric cancer patients. This multicenter cross-sectional study was conducted between 2021 and 2023 at 12 pediatric hematology and oncology clinics. This study included 385 patients (aged 0.3-18 years) with leukemia-lymphoma and solid tumors that are currently on or had newly started oral nutritional supplement (ONS) treatment. Anthropometric measurements, mid-upper-arm-circumference (MUAC), body mass index (BMI), weight-for-age (WFA), were collected, and malnutrition risk was evaluated by the nutrition screening tool for childhood cancer (SCAN). Baseline WFA-based malnutrition was 31.0%, increasing to 38.5%, while SCAN>/=3 was 83.8% decreasing to 72.4% at the sixth month. Malnutrition risk was more common in sarcoma and central nervous system tumor patients. ONS adherence decreased across all cancer types during the follow-up period. Adherent patients demonstrated higher BMI scores during the study period and MUAC z-scores in the last 2 months compared to the non-adherent group (P < 0.04). Our study demonstrates that the use of validated nutrition screening tools, together with adherence strategies, can lead to increased weight-for-age and lower malnutrition risk screening scores. FAU - Kantar, Mehmet AU - Kantar M AUID- ORCID: 0000-0002-1669-4321 AD - Ege University, School of Medicine, Division of Pediatric Oncology, Bornova, Izmir, Turkey. FAU - Bicakli, Derya Hopanci AU - Bicakli DH AD - Ege University, School of Medicine, Division of Pediatric Oncology, Bornova, Izmir, Turkey. FAU - Ozkan, Ayse AU - Ozkan A AD - Cukurova University, School of Medicine, Division of Pediatric Oncology, Adana, Turkey. FAU - Ilhan, Inci AU - Ilhan I AD - Bilkent City Hospital, Pediatric Oncology Unit, Ankara, Turkey. FAU - Tacyildiz, Nurdan AU - Tacyildiz N AD - Ankara University, School of Medicine, Division of Pediatric Oncology, Ankara, Turkey. FAU - Kebudi, Rejin AU - Kebudi R AD - Istanbul University, Institute of Oncology, Division of Pediatric Oncology, Istanbul, Turkey. FAU - Eker, Nursah AU - Eker N AD - Marmara University, School of Medicine, Division of Pediatric Oncology, Istanbul, Turkey. FAU - Sivis, Zuhal AU - Sivis Z AD - Izmir City Hospital, Pediatric Oncology Unit, Izmir, Turkey. FAU - Demirsoy, Ugur AU - Demirsoy U AD - Kocaeli University, School of Medicine, Division of Pediatric Oncology, Kocaeli, Turkey. FAU - Beker, Bahar AU - Beker B AD - Sisli Hamidiye Etfal Training and Research Hospital, Pediatric Oncology Unit, Istanbul, Turkey. FAU - Yesil, Sule AU - Yesil S AD - Etlik City Hospital, Pediatric Hematology and Oncology Unit, Ankara, Turkey. FAU - Varan, Ali AU - Varan A AD - Hacettepe University, School of Medicine, Division of Pediatric Oncology, Ankara, Turkey. FAU - Demirag, Bengu AU - Demirag B AD - Behcet Uz Children's Hospital, Pediatric Oncology Unit, Izmir, Turkey. FAU - Bayram, Ibrahim AU - Bayram I AD - Cukurova University, School of Medicine, Division of Pediatric Oncology, Adana, Turkey. FAU - Ozyoruk, Derya AU - Ozyoruk D AD - Bilkent City Hospital, Pediatric Oncology Unit, Ankara, Turkey. FAU - Ataseven, Eda AU - Ataseven E AD - Ege University, School of Medicine, Division of Pediatric Oncology, Bornova, Izmir, Turkey. FAU - Incesoy, Sonay AU - Incesoy S AD - Ankara University, School of Medicine, Division of Pediatric Oncology, Ankara, Turkey. FAU - Buyukkapu, Sema AU - Buyukkapu S AD - Istanbul University, Institute of Oncology, Division of Pediatric Oncology, Istanbul, Turkey. FAU - Tufan, Burcu AU - Tufan B AD - Marmara University, School of Medicine, Division of Pediatric Oncology, Istanbul, Turkey. FAU - Kizmazoglu, Deniz AU - Kizmazoglu D AD - Izmir City Hospital, Pediatric Oncology Unit, Izmir, Turkey. FAU - Vural, Sema AU - Vural S AD - Sisli Hamidiye Etfal Training and Research Hospital, Pediatric Oncology Unit, Istanbul, Turkey. FAU - Kurucu, Burcak AU - Kurucu B AD - Etlik City Hospital, Pediatric Hematology and Oncology Unit, Ankara, Turkey. FAU - Coskun, Cagri AU - Coskun C AD - Hacettepe University, School of Medicine, Division of Pediatric Oncology, Ankara, Turkey. FAU - Sursal, Alihan AU - Sursal A AD - Neuroscience, Bahcesehir University Faculty of Medicine, Istanbul, Turkey. FAU - Ozkan, Emre AU - Ozkan E AD - Medical Affairs, Nutricia, Specialized Nutrition, Istanbul, Turkey. FAU - Ozdener, Fatih AU - Ozdener F AUID- ORCID: 0000-0002-0163-318X AD - Department of Pharmacology, Bahcesehir University Faculty of Medicine, Istanbul, Turkey. LA - eng PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20251207 PL - United States TA - Nutr Cancer JT - Nutrition and cancer JID - 7905040 SB - IM MH - Humans MH - Child MH - Female MH - Male MH - *Nutritional Status MH - Adolescent MH - Child, Preschool MH - Cross-Sectional Studies MH - *Neoplasms/complications/therapy MH - Infant MH - *Malnutrition/etiology/epidemiology MH - *Patient Compliance/statistics & numerical data MH - *Nutritional Support/methods MH - Body Mass Index MH - Nutrition Assessment EDAT- 2025/12/07 20:35 MHDA- 2025/12/30 00:30 CRDT- 2025/12/07 10:43 PHST- 2025/12/30 00:30 [medline] PHST- 2025/12/07 20:35 [pubmed] PHST- 2025/12/07 10:43 [entrez] AID - 10.1080/01635581.2025.2584473 [doi] PST - ppublish SO - Nutr Cancer. 2026;78(2):145-157. doi: 10.1080/01635581.2025.2584473. Epub 2025 Dec 7. PMID- 41353631 OWN - NLM STAT- MEDLINE DCOM- 20251207 LR - 20260826 IS - 1740-8709 (Electronic) IS - 1740-8695 (Linking) VI - 22 IP - 1 DP - 2026 Mar TI - Applying WHO Prioritization Criteria for Moderate Wasting: Programmatic Implications. PG - e70152 LID - 10.1111/mcn.70152 [doi] AB - The World Health Organization's 2023 recommendations for managing moderate wasting provide criteria for prioritizing children to receive specially formulated foods (SFF) rather than counseling alone. However, the practical programmatic impact of such prioritization is unclear. This secondary analysis aimed to describe the caseload and treatment outcomes among moderately wasted 6- to 59-month-old Malian children, categorized into higher-priority (HP) and lower-priority (LP) groups. All children admitted with a MUAC >/= 115 to < 125 mm without nutritional edema received SFF (500 kcal/day) until they achieved a MUAC >/= 125 mm for 2 consecutive visits. HP criteria were < 2 years old, WAZ < -3 SD, or MUAC 115-119 mm; LP criteria were >/= 2 years, WAZ >/= -3 SD, or MUAC >/= 120 mm. We reported the caseload per priority criterion and compared treatment outcomes, including recovery and anthropometric changes, between LP and HP children. Of the 35 685 children included in the analysis, 95% met at least one priority criterion. The proportion of children recovered was similar between LP and HP children, regardless of the criterion used. MUAC-for-age z-score and WAZ weekly changes showed similar trajectories. Furthermore, although classified as LP, children > 2 years exhibited lower WAZ throughout treatment compared to children < 2 years. Most moderately wasted children (MUAC < 125 mm) met at least one priority criterion, raising concerns about the feasibility and rationale of the prioritization approach. The similar recovery rates in higher- and lower-priority groups after both received SFF highlight the need for research to assess the impact of different interventions. CI - (c) 2025 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Potani, Isabel AU - Potani I AD - International Rescue Committee, New York, New York, USA. AD - Ripple Global Health Network, Lilongwe, Malawi. FAU - Tausanovitch, Zachary AU - Tausanovitch Z AD - International Rescue Committee, New York, New York, USA. FAU - Heymsfield, Grace AU - Heymsfield G AUID- ORCID: 0009-0004-2614-2215 AD - International Rescue Committee, New York, New York, USA. FAU - Ritz, Christian AU - Ritz C AD - National Institute of Public Health, SDU, Denmark. FAU - Cazes, Cecile AU - Cazes C AD - ALIMA, Paris, France. AD - National Institute for Health and Medical Research (INSERM) UMR 1219, Research Institute for Sustainable Development (IRD) EMR 271, Bordeaux Population Health Research Centre, University of Bordeaux, Bordeaux, France. FAU - James, Philip T AU - James PT AD - Emergency Nutrition Network, Oxford, UK. FAU - Briend, Andre AU - Briend A AD - Tampere Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University and Tampere University Hospital, Tampere, Finland. AD - Department of Nutrition, Exercise, and Sports, Faculty of Science, University of Copenhagen, Copenhagen, Denmark. FAU - Coulibaly, Issa Niamanto AU - Coulibaly IN AD - International Rescue Committee, Bamako, Mali. FAU - Khaki, Jessie Jane AU - Khaki JJ AD - Department of Nutrition and Dietetics, School of Global and Public Health, Kamuzu University of Health Sciences, Malawi. FAU - Manda, Geoffrey AU - Manda G AD - Ripple Global Health Network, Lilongwe, Malawi. FAU - Potani, Osborne AU - Potani O AUID- ORCID: 0000-0002-3494-534X AD - Ripple Global Health Network, Lilongwe, Malawi. FAU - Berkley, James A AU - Berkley JA AD - Department of Nutrition and Dietetics, School of Global and Public Health, Kamuzu University of Health Sciences, Malawi. AD - Clinical Research Department, KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya. AD - Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK. FAU - Bailey, Jeanette AU - Bailey J AD - International Rescue Committee, New York, New York, USA. FAU - Kangas, Suvi T AU - Kangas ST AUID- ORCID: 0000-0003-1477-7649 AD - International Rescue Committee, New York, New York, USA. LA - eng PT - Journal Article PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - World Health Organization MH - Infant MH - Child, Preschool MH - Female MH - *Wasting Syndrome/diet therapy/therapy MH - Male MH - Treatment Outcome OTO - NOTNLM OT - combined protocol OT - mid-upper-arm circumference OT - moderate wasting OT - ready-to-use therapeutic food OT - simplified OT - specially formulated food EDAT- 2025/12/07 20:36 MHDA- 2025/12/07 20:37 CRDT- 2025/12/07 09:43 PHST- 2025/11/02 00:00 [revised] PHST- 2025/06/18 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2025/12/07 20:37 [medline] PHST- 2025/12/07 20:36 [pubmed] PHST- 2025/12/07 09:43 [entrez] AID - 10.1111/mcn.70152 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Mar;22(1):e70152. doi: 10.1111/mcn.70152. PMID- 41353177 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260130 LR - 20260201 IS - 2052-1847 (Print) IS - 2052-1847 (Electronic) IS - 2052-1847 (Linking) VI - 18 IP - 1 DP - 2025 Dec 7 TI - Finger pulse monitoring is a reliable and valid tool for measuring heart rate during exercise among adolescents in lab and school settings. PG - 42 LID - 10.1186/s13102-025-01467-x [doi] LID - 42 AB - BACKGROUND: A finger pulse monitor (FPM) offers multiple advantages for monitoring heart rate during exercise in comparison to chest worn monitors, including: enhanced testing efficiency; less invasive, particularly for vulnerable populations (e.g. children); and, reduced cost. The purpose of this study was to establish the test-retest reliability of an FPM device for monitoring heart rate during a 3-minute step test (3MST(30)) to estimate cardiorespiratory fitness in a lab and school setting, and to compare indices of reliability with a chest worn heart rate monitor. METHODS: Participants (N = 29; male = 16, female = 13; age: 15.8 +/- 0.7) completed the 3MST(30) on two occasions, in a lab setting (T1) and in a school setting (T2), one week apart. Participants wore a Braun((R)) FPM and a Polar((R)) H7 chest strap heart rate monitor. Heart rate in beats per minute (bpm) was recorded on both devices at 1-minute, 2-minutes, 3-minutes, and one minute following test completion. Equivalence testing was used to analyse the data for differences between the two devices by using the TOSTER R package. RESULTS: Absolute mean differences between devices and settings were clinically insignificant, with the smallest variance at the 1-minute post recording (FPM p = .012; chest strap = 0.041). There were no statistically significant differences in heart rate measurement between settings. CONCLUSIONS: This study demonstrates that finger pulse monitoring is a reliable and valid tool for measuring heart rate during sub-maximal exercise in lab and school settings. CI - (c) 2026. The Author(s). FAU - O'Keeffe, Brendan T AU - O'Keeffe BT AUID- ORCID: 0000-0002-4590-3460 AD - Department of Physical Education and Sport Sciences, University of Limerick, Limerick, Ireland. Brendan.okeeffe@ul.ie. AD - Health Research Institute, University of Limerick, Limerick, Ireland. Brendan.okeeffe@ul.ie. FAU - Britton, Una AU - Britton U AD - SFI Insight Centre for Data Analytics, Dublin City University, Dublin, Ireland. FAU - Ng, Kwok AU - Ng K AD - Department of Physical Education and Sport Sciences, University of Limerick, Limerick, Ireland. AD - Health Research Institute, University of Limerick, Limerick, Ireland. AD - Department of Teacher Education, University of Turku, Turku, Finland. AD - Institute of Sports Science and Innovation, Lithuanian Sports University, Kaunas, Lithuania. LA - eng PT - Journal Article DEP - 20251207 PL - England TA - BMC Sports Sci Med Rehabil JT - BMC sports science, medicine & rehabilitation JID - 101605016 PMC - PMC12857018 OTO - NOTNLM OT - Cardiorespiratory endurance OT - Exercise testing OT - Physical fitness OT - Step test COIS- Declarations. Ethics approval and consent to participate: The Helsinki Declaration guidelines were applied in this study and research ethics approval and the associated protocols was granted by the research ethics committee of the Faculty of Education and Health Sciences, University of Limerick (Approval No. 2022_06_27_EHS). Informed consent to participate was received from the school principal, the participants, and their parents. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/07 00:40 MHDA- 2025/12/07 00:41 PMCR- 2025/12/07 CRDT- 2025/12/06 23:17 PHST- 2025/07/17 00:00 [received] PHST- 2025/11/27 00:00 [accepted] PHST- 2025/12/07 00:41 [medline] PHST- 2025/12/07 00:40 [pubmed] PHST- 2025/12/06 23:17 [entrez] PHST- 2025/12/07 00:00 [pmc-release] AID - 10.1186/s13102-025-01467-x [pii] AID - 1467 [pii] AID - 10.1186/s13102-025-01467-x [doi] PST - epublish SO - BMC Sports Sci Med Rehabil. 2025 Dec 7;18(1):42. doi: 10.1186/s13102-025-01467-x. PMID- 41352252 OWN - NLM STAT- MEDLINE DCOM- 20260306 LR - 20260306 IS - 1286-0115 (Print) IS - 1286-0115 (Linking) VI - 110 IP - 368 DP - 2026 Mar TI - External validation of a country-specific model for radiographic dental age assessment of Brazilian children and adolescents. PG - 101099 LID - S1286-0115(25)00151-1 [pii] LID - 10.1016/j.morpho.2025.101099 [doi] AB - Dental age assessment may have important clinical and forensic applications. Testing the existing methods is fundamental to promoting best clinical and forensic practices. The present study aimed to test a Brazilian country-specific model for dental age assessment in a population of Bahia State, Brazil. A total of 1009 panoramic radiographs of Brazilian individuals (n=556, 55.1% females and 453, 44.9% males) aged between 6 and 15.99 years were collected. The seven permanent left mandibular teeth from central incisor to second molar were analyzed in each radiograph. Demirjian's dental staging technique was applied followed by age estimation through Franco's dental age assessment model. Differences between chronological and estimated ages were quantified as mean error (ME), mean absolute error (MAE), and root means squared error (RMSE). The overall (sex combined) ME, MAE, RMSE were -0.51, 1.11, 1.63, respectively. For females and males separately, the error metrics were: -0.55, 1.16, 1.65 and -0.45, 1.05, 1.59, respectively. Bland-Altman plots showed narrower age limits among males, while higher discrepancies were observed for females. The analysis based on age categories showed the worst predictions between the ages of 6 and 6.99 years. The tested country-specific model was applicable to individuals aged above 7 years in the target population, being an alternative for dental age assessment. CI - Copyright (c) 2025 Elsevier Masson SAS. All rights reserved. FAU - de Oliveira, A F AU - de Oliveira AF AD - Division of Forensic Dentistry, Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. FAU - Zanovello, B P AU - Zanovello BP AD - Division of Forensic Dentistry, Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. FAU - Moreira, D D AU - Moreira DD AD - Division of Oral Radiology, Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil. FAU - Franco, A AU - Franco A AD - Division of Forensic Dentistry, Faculdade Sao Leopoldo Mandic, Campinas, SP, Brazil; Department of Therapeutic Stomatology, Institute of Dentistry, Sechenov University, Moscow, Russia. Electronic address: ademir.junior@slmandic.edu.br. LA - eng PT - Journal Article PT - Validation Study DEP - 20251205 PL - France TA - Morphologie JT - Morphologie : bulletin de l'Association des anatomistes JID - 9814314 SB - IM MH - Humans MH - *Age Determination by Teeth/methods MH - Female MH - Male MH - Adolescent MH - Child MH - Brazil MH - *Radiography, Panoramic MH - *Tooth/diagnostic imaging/growth & development OTO - NOTNLM OT - Age OT - Forensic dentistry OT - Radiology OT - Tooth COIS- Disclosure of interest The authors declare that they have no competing interest. EDAT- 2025/12/07 00:41 MHDA- 2026/03/06 19:43 CRDT- 2025/12/06 18:12 PHST- 2025/10/20 00:00 [received] PHST- 2025/11/22 00:00 [revised] PHST- 2025/11/23 00:00 [accepted] PHST- 2026/03/06 19:43 [medline] PHST- 2025/12/07 00:41 [pubmed] PHST- 2025/12/06 18:12 [entrez] AID - S1286-0115(25)00151-1 [pii] AID - 10.1016/j.morpho.2025.101099 [doi] PST - ppublish SO - Morphologie. 2026 Mar;110(368):101099. doi: 10.1016/j.morpho.2025.101099. Epub 2025 Dec 5. PMID- 41352210 OWN - NLM STAT- MEDLINE DCOM- 20260108 LR - 20260108 IS - 1872-6283 (Electronic) IS - 0379-0738 (Linking) VI - 379 DP - 2026 Jan TI - Forensic gender and stature identification from footprint images using machine learning. PG - 112760 LID - S0379-0738(25)00404-9 [pii] LID - 10.1016/j.forsciint.2025.112760 [doi] AB - The analysis of footprints to infer human characteristics and biometric information is a valuable tool in forensic investigation. Traditional methods rely primarily on physical measurements and observational analysis, which requires significant time, effort and specialized expert judgment. This study proposes a novel, automated, end-to-end approach to gender classification and stature estimation from footprints, using image analysis and traditional machine learning methods. Specifically, this we employ a image pre-processing techniques for Region of Interest extraction to segment foot prints in images and identify toe and heel exterior points through convexity and defectiveness points. The study utilized a dataset of 396 footprints from 33 participants (18 males and 15 females, aged 18-48 years, height range 148-182 cm). Hyper-parameter tuning via grid search optimization is employed and traditional Machine Learning (ML) models, including Logistic Regression (LR), Gaussian Naive Bayes (GNB), K-Nearest Neighbor (KNN), Decision Tree Classifier (DTC), and Support Vector Machine (SVM), are benchmarked for the task of both inferring gender, and stature. We specifically focus on traditional ML methods due to their relatively modest training data requirements, with the aim of establishing their feasibility for such forensic analysis. KNN demonstrated better accuracy overall for gender classification achieving 0.91 accuracy, while Extreme Gradient Boosting (XGBoost) outperformed other methods for stature estimation with MAE of 4.10 cm and RMSE of 5.42 cm, however varying strengths and weaknesses of each classifier for gender classification and stature estimation were observed. Our results suggest that the strongest performing traditional ML methods offer a feasible solution for such analysis, however expanding the training dataset to incorporate more footprint examples of more varying quality and depicting a greater diversity of population is likely necessary to fully realise a workable end-to-end solution. Such datasets may also open the door to more advanced deep learning methods. CI - Copyright (c) 2025 The Authors. Published by Elsevier B.V. All rights reserved. FAU - Khalid, Mashal AU - Khalid M AD - Swinburne University of Technology, Melbourne, Australia. FAU - Kameneva, Tatiana AU - Kameneva T AD - Swinburne University of Technology, Melbourne, Australia. FAU - McCarthy, Chris AU - McCarthy C AD - Swinburne University of Technology, Melbourne, Australia. Electronic address: cdmccarthy@swin.edu.au. LA - eng PT - Journal Article DEP - 20251202 PL - Ireland TA - Forensic Sci Int JT - Forensic science international JID - 7902034 SB - IM MH - Humans MH - Adult MH - Female MH - Male MH - *Machine Learning MH - Adolescent MH - Young Adult MH - Middle Aged MH - *Body Height MH - *Foot/anatomy & histology/diagnostic imaging MH - *Image Processing, Computer-Assisted MH - Support Vector Machine MH - Decision Trees MH - Logistic Models MH - Bayes Theorem MH - Forensic Anthropology OTO - NOTNLM OT - Anthropometry OT - Biometric analysis OT - Footprint OT - Image Analysis OT - Machine Learning COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/07 00:40 MHDA- 2026/01/09 00:26 CRDT- 2025/12/06 18:10 PHST- 2025/02/20 00:00 [received] PHST- 2025/08/19 00:00 [revised] PHST- 2025/11/30 00:00 [accepted] PHST- 2026/01/09 00:26 [medline] PHST- 2025/12/07 00:40 [pubmed] PHST- 2025/12/06 18:10 [entrez] AID - S0379-0738(25)00404-9 [pii] AID - 10.1016/j.forsciint.2025.112760 [doi] PST - ppublish SO - Forensic Sci Int. 2026 Jan;379:112760. doi: 10.1016/j.forsciint.2025.112760. Epub 2025 Dec 2. PMID- 41351877 OWN - NLM STAT- MEDLINE DCOM- 20260902 LR - 20260915 IS - 1753-4887 (Electronic) IS - 0029-6643 (Print) IS - 0029-6643 (Linking) VI - 84 IP - 10 DP - 2026 Oct 1 TI - Eyes on Development: Exploring the Impact of Early Life Nutrition Exposures on Child Cognition Through Eye-Tracking Assessment. PG - 2193-2212 LID - 10.1093/nutrit/nuaf235 [doi] AB - BACKGROUND: The effects of certain nutrients on cognition in early life are hypothesized to be domain specific. Previous studies have examined the associations between child nutrition and cognitive, motor, or socio-emotional development, but the assessment methods are often insensitive to the specific functional domains affected by nutrition. OBJECTIVE: This scoping review had 2 objectives: (1) to synthesize evidence on the impact of early life nutrition exposures on child cognition evaluated using eye-tracking assessment and (2) to describe the use of eye trackers for child cognitive assessment and to provide recommendations for eye-tracking implementation in future research. METHODS: A systematic search was performed using the databases PubMed, Embase, and Food Science and Technology Abstracts, from database inception to April 2024. Additionally, we hand searched reference lists of eligible studies to identify additional relevant publications. We included studies of any nutrition exposures (intervention or assessment) involving pregnant or lactating mothers or children aged 0-5 years, with child cognitive outcomes assessed using eye-tracking assessments. The review was conducted following the PRISMA-ScR checklist. RESULTS: A total of 1140 article titles and abstracts were screened, with 9 articles included in this review (3 randomized controlled trials, 5 prospective cohort studies, and 1 cross-sectional and prospective cohort study nested in a trial). The majority of the studies were conducted in low- and middle-income countries. Despite the limited number of nutrition studies using eye-tracking assessments, 5 of the 9 studies demonstrated significant relationships between nutrition exposures and attention and memory outcomes. Eye-tracking assessments were also found to be feasible across multiple settings. CONCLUSION: Eye-tracking assessment is a feasible and promising method for evaluating the effects of early life nutrition exposures on attention and memory outcomes across settings. However, the selection of eye-tracking-based tasks should be tailored to the type of nutrition exposures, the desired long-term outcomes, and the feasibility of proper training for local staff. CI - (c) The Author(s) 2025. Published by Oxford University Press on behalf of the International Life Sciences Institute. FAU - Rianda, Davrina AU - Rianda D AUID- ORCID: 0000-0001-9919-2249 AD - Department of Nutrition, University of California, Davis, CA 95616, United States. AD - Institute for Global Nutrition, University of California, Davis, CA 95616, United States. AD - Human Nutrition Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia. FAU - Mjaaseth, Ulrik N AU - Mjaaseth UN AUID- ORCID: 0000-0003-4783-4902 AD - Department of Nutrition, University of California, Davis, CA 95616, United States. FAU - DeBolt, Michaela C AU - DeBolt MC AUID- ORCID: 0000-0001-8820-4099 AD - Center for Mind and Brain, University of California at Davis, Davis, CA 95616, United States. AD - Department of Psychology, University of California at Davis, Davis, CA 95616, United States. FAU - Agustina, Rina AU - Agustina R AUID- ORCID: 0000-0002-8464-1037 AD - Human Nutrition Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia. AD - Department of Nutrition, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo General Hospital, Jakarta 10430, Indonesia. FAU - Oakes, Lisa M AU - Oakes LM AUID- ORCID: 0000-0002-6701-2853 AD - Center for Mind and Brain, University of California at Davis, Davis, CA 95616, United States. AD - Department of Psychology, University of California at Davis, Davis, CA 95616, United States. FAU - Stewart, Christine P AU - Stewart CP AUID- ORCID: 0000-0003-4575-8571 AD - Department of Nutrition, University of California, Davis, CA 95616, United States. AD - Institute for Global Nutrition, University of California, Davis, CA 95616, United States. LA - eng GR - Indonesia Endowment Fund for Education/ GR - PUTI NKB-297/UN2.RST/FKP.05.00/2024/Universitas Indonesia/ GR - NIGMS/ GR - T32 144303/Pharmacology Training Program/ GR - T32 144303/NIGMS-funded Pharmacology Training Program/ PT - Journal Article PT - Scoping Review PL - United States TA - Nutr Rev JT - Nutrition reviews JID - 0376405 SB - IM MH - Child, Preschool MH - Female MH - Humans MH - Infant MH - Infant, Newborn MH - Pregnancy MH - *Child Development/physiology MH - *Child Nutritional Physiological Phenomena MH - *Cognition/physiology MH - *Eye-Tracking Technology MH - *Infant Nutritional Physiological Phenomena MH - *Nutritional Status PMC - PMC13537450 OTO - NOTNLM OT - child nutrition OT - cognitive development OT - eye-tracking OT - maternal nutrition COIS- None declared. EDAT- 2025/12/06 21:31 MHDA- 2026/09/03 01:13 PMCR- 2025/12/06 CRDT- 2025/12/06 15:22 PHST- 2026/09/03 01:13 [medline] PHST- 2025/12/06 21:31 [pubmed] PHST- 2025/12/06 15:22 [entrez] PHST- 2025/12/06 00:00 [pmc-release] AID - 8373434 [pii] AID - nuaf235 [pii] AID - 10.1093/nutrit/nuaf235 [doi] PST - ppublish SO - Nutr Rev. 2026 Oct 1;84(10):2193-2212. doi: 10.1093/nutrit/nuaf235. PMID- 41351317 OWN - NLM STAT- MEDLINE DCOM- 20251206 LR - 20251206 IS - 1399-3038 (Electronic) IS - 0905-6157 (Linking) VI - 36 IP - 12 DP - 2025 Dec TI - Performance analysis of artificial intelligence-based classification models for diagnosing asthma in children. PG - e70258 LID - 10.1111/pai.70258 [doi] AB - INTRODUCTION: Asthma is a common childhood disease with symptoms such as cough, wheezing, and shortness of breath. This study evaluated the role of artificial intelligence in improving diagnostic accuracy in children. METHODS: We included patients aged 6-18 years evaluated at our clinic between January 2024 and January 2025. Those with chronic cough were classified as asthma or non-asthma based on final diagnosis. Demographic, clinical, and pulmonary function data were collected. Eight machine learning models Gradient Boosting, AdaBoost, Random Forest, Logistic Regression, Linear Discriminant Analysis, Decision Tree, k-Nearest Neighbors, and Naive Bayes were applied, and their performance was assessed using accuracy, precision, recall, F1 score, ROC AUC, and MCC. RESULTS: A total of 900 children were included, with 450 diagnosed with asthma and 450 with non-asthmatic chronic cough. Males comprised 52.9% of the cohort. Feature importance analysis highlighted exercise-induced cough and recurrent bronchiolitis as the most significant predictors for asthma. Gradient Boosting demonstrated the highest diagnostic performance (F1: 0.974, ROC AUC: 0.997), followed closely by Random Forest (F1: 0.972, ROC AUC: 0.997) and AdaBoost (F1: 0.969, ROC AUC: 0.995). Logistic Regression, LDA, Decision Tree, and Naive Bayes showed moderate performance, while KNN had the lowest accuracy (F1: 0.566, ROC AUC: 0.615), indicating variable effectiveness among models. DISCUSSION: Machine learning algorithms show promise in improving diagnostic accuracy and efficiency in pediatric asthma, though further research is needed. CI - (c) 2025 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd. FAU - Yorusun, Gokhan AU - Yorusun G AD - Ankara Bilkent City Hospital Pediatric Immunology and Allergy, Ankara, Turkiye. FAU - Yilmaz Topal, Ozge AU - Yilmaz Topal O AD - Ankara Bilkent City Hospital Pediatric Immunology and Allergy, Ankara, Turkiye. FAU - Erdas, Cagatay Berke AU - Erdas CB AD - Department of Computer Engineering, Baskent University Faculty of Engineering, Ankara, Turkiye. FAU - Aytekin Guvenir, Funda AU - Aytekin Guvenir F AD - Ankara Bilkent City Hospital Pediatric Immunology and Allergy, Ankara, Turkiye. FAU - Selmanoglu, Ahmet AU - Selmanoglu A AD - Ankara Bilkent City Hospital Pediatric Immunology and Allergy, Ankara, Turkiye. FAU - Sengul Emeksiz, Zeynep AU - Sengul Emeksiz Z AD - Ankara Bilkent City Hospital Pediatric Immunology and Allergy, Ankara, Turkiye. FAU - Dibek Misirlioglu, Emine AU - Dibek Misirlioglu E AUID- ORCID: 0000-0002-3241-2005 AD - Ankara Bilkent City Hospital Pediatric Immunology and Allergy, Ankara, Turkiye. LA - eng PT - Journal Article PL - England TA - Pediatr Allergy Immunol JT - Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology JID - 9106718 SB - IM MH - Humans MH - *Asthma/diagnosis/classification MH - Child MH - Male MH - Female MH - Adolescent MH - *Artificial Intelligence MH - *Machine Learning MH - ROC Curve MH - Cough/diagnosis MH - Decision Trees MH - Bayes Theorem OTO - NOTNLM OT - artificial intelligence OT - diagnostic accuracy OT - machine learning OT - pediatric asthma EDAT- 2025/12/06 06:32 MHDA- 2025/12/06 06:33 CRDT- 2025/12/06 03:02 PHST- 2025/11/19 00:00 [revised] PHST- 2025/09/20 00:00 [received] PHST- 2025/11/24 00:00 [accepted] PHST- 2025/12/06 06:33 [medline] PHST- 2025/12/06 06:32 [pubmed] PHST- 2025/12/06 03:02 [entrez] AID - 10.1111/pai.70258 [doi] PST - ppublish SO - Pediatr Allergy Immunol. 2025 Dec;36(12):e70258. doi: 10.1111/pai.70258. PMID- 41351293 OWN - NLM STAT- MEDLINE DCOM- 20260609 LR - 20260720 IS - 1469-8749 (Electronic) IS - 0012-1622 (Linking) VI - 68 IP - 7 DP - 2026 Jul TI - The Children's Eating and Drinking Activity Scale: Interrater reliability, concurrent validity, and responsiveness. PG - 952-958 LID - 10.1111/dmcn.70110 [doi] AB - AIM: To assess the interrater reliability, concurrent validity, and responsiveness of the Children's Eating and Drinking Activity Scale (CEDAS). METHOD: Interrater reliability was assessed using an online questionnaire completed by speech and language therapists working in hospital and community settings. Participants (n = 39) applied CEDAS to 12 vignettes. Interrater reliability was calculated using Krippendorff's alpha (alpha). Additionally, CEDAS was applied retrospectively to consecutive speech and language therapy referrals at a single hospital (n = 85, median age 11 years 2 months, range 1 week-17 years 1 month). Responsiveness was assessed by comparing median CEDAS scores at referral, after initial speech and language therapy assessment, and at discharge. The Functional Status Scale (FSS) feeding domain was used to evaluate concurrent validity. RESULTS: Interrater reliability was excellent (Krippendorff's alpha = 0.927). CEDAS was responsive to change, with expected score increases seen between referral and discharge (Z = -4.37, p < 0.001), and initial assessment and discharge (Z = -3.23, p < 0.001). Strong concurrent validity was established with the FSS (r(s) = -0.77 to -0.99, p < 0.003). INTERPRETATION: CEDAS demonstrates excellent interrater reliability across clinical settings. It is a responsive tool with established construct validity when used in an acute hospital setting. CI - (c) 2025 The Author(s). Developmental Medicine & Child Neurology published by John Wiley & Sons Ltd on behalf of Mac Keith Press. FAU - Mantaring, Ericka Joinelle AU - Mantaring EJ AD - Department of Language and Cognition, University College London, London, UK. FAU - Wong, Sheung Yu Sylfiana AU - Wong SYS AD - Department of Language and Cognition, University College London, London, UK. FAU - McInerney, Michelle AU - McInerney M AD - Department of Language and Cognition, University College London, London, UK. FAU - Thorpe, Vicky AU - Thorpe V AD - Department of Speech and Language Therapy, Great Ormond Street Hospital for Children, London, UK. FAU - Stewart, Alexandra AU - Stewart A AUID- ORCID: 0000-0003-2170-6769 AD - Department of Language and Cognition, University College London, London, UK. AD - Department of Speech and Language Therapy, Great Ormond Street Hospital for Children, London, UK. LA - eng GR - Health Education England and the National Institute for Health and Care Research (NIHR)/ PT - Journal Article DEP - 20251205 PL - England TA - Dev Med Child Neurol JT - Developmental medicine and child neurology JID - 0006761 SB - IM MH - Humans MH - Reproducibility of Results MH - Child, Preschool MH - Child MH - Female MH - Male MH - Adolescent MH - Infant MH - Observer Variation MH - Surveys and Questionnaires MH - Retrospective Studies MH - Infant, Newborn MH - Psychometrics MH - *Feeding Behavior/physiology EDAT- 2025/12/06 06:33 MHDA- 2026/06/09 06:36 CRDT- 2025/12/06 02:14 PHST- 2025/10/08 00:00 [revised] PHST- 2025/05/22 00:00 [received] PHST- 2025/10/15 00:00 [accepted] PHST- 2026/06/09 06:36 [medline] PHST- 2025/12/06 06:33 [pubmed] PHST- 2025/12/06 02:14 [entrez] AID - 10.1111/dmcn.70110 [doi] PST - ppublish SO - Dev Med Child Neurol. 2026 Jul;68(7):952-958. doi: 10.1111/dmcn.70110. Epub 2025 Dec 5. PMID- 41350990 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260729 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2025 Dec 5 TI - Hard- and soft-tissue changes following the treatment of growing patients with skeletal class III malocclusion using the lower-clear-plate based intermaxillary traction versus the removable mandibular retractor: a two-arm randomized controlled trial. PG - 61 LID - 10.1186/s12903-025-07474-1 [doi] LID - 61 AB - BACKGROUND: Increased interest in intraoral devices like Bionator III, reverse twin block, and removable mandibular retractor (RMR), which modify tissues beneficially. The emerging Orthodontic Removable Traction Appliance (ORTA) or the lower-clear-plate-based intermaxillary traction (LCP-IMT) has shown promising results, especially in stimulating maxillary growth and inhibiting mandibular growth in Class III malocclusion. OBJECTIVES: To evaluate the effectiveness of the LCP-IMT against the RMR during the early correction of Class III deformities in growing patients regarding skeletal, dental, and soft tissue variables. METHODS: A two-arm randomized controlled clinical trial was conducted from July 8, 2023, to June 15, 2024, at the Department of Orthodontics, University of Damascus. It enrolled patients aged 9 to 13 with mild to moderate skeletal Class III malocclusion (ANB + 1 to -3 degrees), an anterior crossbite involving two or more teeth, or an edge-to-edge relationship. Participants had normal or horizontal growth patterns (MM 0.05), despite slightly greater SNA and ANB changes in the LCP-IMT group. Dentally, both groups showed favorable outcomes; however, the RMR group exhibited significantly greater lower incisor lingual inclination (L1.ManP: - 7.66 degrees vs. - 5.05 degrees , P = 0.016). Differences between the two groups in overjet, overbite, and soft tissue parameters-including upper lip protrusion and nasolabial angle did not reach statistical significance. CONCLUSIONS: Both appliances produced comparable short-term dental and soft-tissue improvements; a between-group difference in lower-incisor inclination favored LCP-IMT. These preliminary results require confirmation in larger and longer-term trials. TRIAL REGISTRATION: This study was retrospectively retrospectively registered in the Clinical Trials database (ID: NCT06596239) on the 11/09/2024. URL: https://clinicaltrials.gov/study/NCT06596239 . FAU - Kheshfeh, Mohammad N AU - Kheshfeh MN AD - Department of Orthodontics, Faculty of Dentistry, University of Damascus, Damascus, Syria. FAU - Nassar, Neriman AU - Nassar N AD - Department of Orthodontics, Faculty of Dentistry, University of Damascus, Damascus, Syria. FAU - Hajeer, Mohammad Y AU - Hajeer MY AD - Department of Orthodontics, Faculty of Dentistry, University of Damascus, Damascus, Syria. myhajeer@gmail.com. AD - Department of Orthodontics, School of Dentistry, University of Jordan, Amman, 11942, Jordan. myhajeer@gmail.com. FAU - Aljabban, Ossama AU - Aljabban O AD - Department of Restorative Dentistry and Endodontics, Faculty of Dentistry, Damascus University, Damascus, Syria. FAU - Alam, Mohammad Khursheed AU - Alam MK AD - Orthodontic Division, Preventive Dentistry Department, College of Dentistry, Jouf University, Sakaka, 72345, Saudi Arabia. LA - eng SI - ClinicalTrials.gov/NCT06596239 GR - 501100020595/Damascus University/ PT - Comparative Study PT - Journal Article PT - Randomized Controlled Trial DEP - 20251205 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Malocclusion, Angle Class III/therapy MH - Child MH - Cephalometry/methods MH - Female MH - Adolescent MH - Male MH - *Mandible/growth & development/pathology MH - Orthodontic Appliance Design MH - *Orthodontic Appliances, Removable MH - Maxilla/growth & development/pathology MH - *Extraoral Traction Appliances MH - Incisor/pathology MH - Treatment Outcome MH - Maxillofacial Development PMC - PMC12797752 OTO - NOTNLM OT - Anterior crossbite OT - Dental changes OT - Skeletal changes OT - Skeletal class III OT - Soft tissue changes COIS- Declaration. Ethics approval and consent to participate: The study was approved by the Local Research Ethics Committee of the Faculty of Dentistry, University of Damascus (UDDS-594-10072023/SRC-2945). All procedures involving human participants were performed in accordance with the ethical standards of the Institutional Research Committee and with Declaration of Helsinki and its later amendments. As all participants in this study were children aged between 9 and 13 years, informed consent to participate was obtained from their parents or legal guardians. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/06 00:32 MHDA- 2026/06/27 00:57 PMCR- 2025/12/05 CRDT- 2025/12/05 23:55 PHST- 2025/07/04 00:00 [received] PHST- 2025/12/01 00:00 [accepted] PHST- 2026/06/27 00:57 [medline] PHST- 2025/12/06 00:32 [pubmed] PHST- 2025/12/05 23:55 [entrez] PHST- 2025/12/05 00:00 [pmc-release] AID - 10.1186/s12903-025-07474-1 [pii] AID - 7474 [pii] AID - 10.1186/s12903-025-07474-1 [doi] PST - epublish SO - BMC Oral Health. 2025 Dec 5;26(1):61. doi: 10.1186/s12903-025-07474-1. PMID- 41349871 OWN - NLM STAT- MEDLINE DCOM- 20260124 LR - 20260124 IS - 1879-1220 (Electronic) IS - 0960-0760 (Linking) VI - 257 DP - 2026 Mar TI - Vitamin D metabolite ratio as a marker of nutritional bone health in adolescents. PG - 106918 LID - S0960-0760(25)00246-8 [pii] LID - 10.1016/j.jsbmb.2025.106918 [doi] AB - Vitamin D deficiency is a widespread public health issue among Saudi adolescents, posing significant risks to bone health and long-term well-being. Traditional markers such as serum 25-hydroxyvitamin D [25(OH)D] may not fully capture functional vitamin D status, particularly during critical growth periods such as adolescence. This study aimed to evaluate vitamin D metabolite levels and their association with calcium intake and bone health markers in Saudi adolescents, with a focus on the vitamin D metabolite ratio (VMR) as a potential indicator of functional vitamin D sufficiency. A cross-sectional analysis was conducted involving 949 (54 % females) Saudi adolescents. Serum levels of vitamin D metabolites, including 25(OH)D; 24,25-dihydroxyvitamin D [24,25(OH)(2)D], and 25(OH)D(2), were measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS). VMR was calculated as the ratio of 24,25(OH)(2)D to 25(OH)D. Dietary calcium intake was assessed via validated questionnaires. Parathyroid hormone (PTH) and serum calcium levels were analyzed in a subset of participants. Vitamin D deficiency was highly prevalent, with 86.5 % of participants showing insufficient 25(OH)D levels. Over 93 % had low 24,25(OH)(2)D, 99.7 % had undetectable 25(OH)D(2), and 74.9 % exhibited low VMR. VMR was significantly associated with serum and dietary calcium intake among girls, but not boys, suggesting potential sex-specific metabolic differences. Additionally, only VMR showed a significant association with serum calcium. An inverse association between PTH and both total vitamin D (r = -0.28, p < 0.05) and serum calcium (r = -0.34, p < 0.01) was observed in the subset analysis. In conclusion, VMR may serve as a useful sex-specific biomarker of functional vitamin D status in adolescents. The findings highlight the importance of addressing both intake and metabolic processing of vitamin D to optimize bone health during adolescence. CI - Copyright (c) 2025 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Al-Daghri, Nasser M AU - Al-Daghri NM AD - Chair for Biomarkers of Chronic Diseases, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. Electronic address: ndaghri@ksu.edu.sa. FAU - Alenad, Amal M AU - Alenad AM AD - Chair for Biomarkers of Chronic Diseases, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia; Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. FAU - Sabico, Shaun AU - Sabico S AD - Chair for Biomarkers of Chronic Diseases, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. FAU - Wani, Kaiser AU - Wani K AD - Chair for Biomarkers of Chronic Diseases, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. FAU - Al-Saleh, Yousef AU - Al-Saleh Y AD - Department of Medicine, Healthoasis Hospital, Riyadh, Saudi Arabia. FAU - Khattak, Malak N K AU - Khattak MNK AD - Chair for Biomarkers of Chronic Diseases, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. FAU - Alnaami, Abdullah M AU - Alnaami AM AD - Chair for Biomarkers of Chronic Diseases, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. FAU - Fakhurji, Leena T AU - Fakhurji LT AD - Department of Food Science & Nutrition, College of Food & Agriculture Science, King Saud University, PO Box 2460, Riyadh 11495, Saudi Arabia. FAU - Alokail, Majed S AU - Alokail MS AD - Protein Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. FAU - Reginster, Jean-Yves AU - Reginster JY AD - Protein Research Chair, Department of Biochemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. FAU - Cavalier, Etienne AU - Cavalier E AD - Department of Clinical Chemistry, University of Liege, CIRM, CHU de Liege, Liege, Belgium. LA - eng PT - Journal Article DEP - 20251203 PL - England TA - J Steroid Biochem Mol Biol JT - The Journal of steroid biochemistry and molecular biology JID - 9015483 RN - 1406-16-2 (Vitamin D) RN - 0 (Biomarkers) RN - A288AR3C9H (25-hydroxyvitamin D) RN - 0 (Parathyroid Hormone) RN - 0 (Calcium, Dietary) RN - SY7Q814VUP (Calcium) SB - IM MH - Humans MH - Female MH - Adolescent MH - Male MH - *Vitamin D/blood/analogs & derivatives/metabolism MH - Biomarkers/blood MH - *Vitamin D Deficiency/blood/epidemiology MH - Cross-Sectional Studies MH - Saudi Arabia/epidemiology MH - Parathyroid Hormone/blood MH - Calcium, Dietary/administration & dosage MH - *Bone and Bones/metabolism MH - Calcium/blood OTO - NOTNLM OT - 25(OH)(2)D] OT - 25-dihydroxyvitamin D [24 OT - 25-hydroxyvitamin D [25(OH)D] OT - 4 OT - Adolescents OT - Bone health OT - Saudi population OT - Vitamin D metabolite ratio (VMR) COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/06 00:32 MHDA- 2026/01/25 00:37 CRDT- 2025/12/05 19:35 PHST- 2025/08/27 00:00 [received] PHST- 2025/11/06 00:00 [revised] PHST- 2025/12/02 00:00 [accepted] PHST- 2026/01/25 00:37 [medline] PHST- 2025/12/06 00:32 [pubmed] PHST- 2025/12/05 19:35 [entrez] AID - S0960-0760(25)00246-8 [pii] AID - 10.1016/j.jsbmb.2025.106918 [doi] PST - ppublish SO - J Steroid Biochem Mol Biol. 2026 Mar;257:106918. doi: 10.1016/j.jsbmb.2025.106918. Epub 2025 Dec 3. PMID- 41349851 OWN - NLM STAT- MEDLINE DCOM- 20251217 LR - 20261014 IS - 1095-9572 (Electronic) IS - 1053-8119 (Linking) VI - 324 DP - 2025 Dec 15 TI - Head to head: Comparing intracranial volumes using 3D ultrasound and fetal MRI. PG - 121633 LID - S1053-8119(25)00636-6 [pii] LID - 10.1016/j.neuroimage.2025.121633 [doi] AB - OBJECTIVE(S): Recent advances in fetal three-dimensional (3D) ultrasound (US) enable automated intracranial volume (ICV) measurements. If US yields results comparable to magnetic resonance imaging (MRI), it could serve as a fast, cost-effective, and scalable alternative. This study directly compares and visualizes ICV measurements from fetal 3D US and 3D MRI. STUDY DESIGN: We applied automated ICV segmentation to US and MRI data from healthy participants. In a subset of fetuses who underwent both US and MRI within 24 h, we evaluated ICV agreement using the intraclass correlation coefficient (ICC) and the Dice similarity coefficient (DSC). As a proof of principle, we also generated a multimodal ICV trajectory incorporating fetal US, fetal MRI, and neonatal MRI. RESULTS: Among the 71 participants, 47 had high-quality US scans at 20 and 30 weeks of gestation, 61 had high-quality fetal MRI, and 47 had high-quality neonatal MRI. Thirteen fetuses around 30 weeks had US and MRI scans acquired within 24 h, showing good agreement with an ICC of 0.797 and DSC(US-MRI) scores of 0.900-0.925. Mean ICV values were 80 +/- 12 ml around 22 weeks (US), 248 +/- 28 ml around 30 weeks (US), 294 +/- 36 ml around 32 weeks (fetal MRI) and 508 +/- 51 ml around 43 weeks (neonatal MRI). CONCLUSION(S): Fetal US and MRI yield comparable ICV measurements around 30 weeks of gestation, validating automatic 3D US volumetric methods. The use of 3D US may support development of normative curves and improve comparisons with at-risk fetuses, including in regions where fetal MRI is less accessible. CI - Copyright (c) 2025. Published by Elsevier Inc. FAU - van Ooijen, Inge M AU - van Ooijen IM AD - Department of Neonatology, Division Woman & Baby, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Radiology, Division Imaging, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. Electronic address: i.m.vanooijen-2@umcutrecht.nl. FAU - van Iersel, Gaby AU - van Iersel G AD - Department of Neonatology, Division Woman & Baby, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Developmental Psychology, Utrecht University, Utrecht, the Netherlands; Eindhoven University of Technology, Electrical Engineering- Lab of Biomedical Diagnostics, Eindhoven, the Netherlands. FAU - Meijerink, Lotte AU - Meijerink L AD - Department of Obstetrics, Division Woman & Baby, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. FAU - Teeuw, Jalmar AU - Teeuw J AD - Department of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the Netherlands. FAU - Turk, Elise AU - Turk E AD - Department of Neonatology, Division Woman & Baby, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Eindhoven University of Technology, Electrical Engineering- Lab of Biomedical Diagnostics, Eindhoven, the Netherlands. FAU - Nijman, Maaike AU - Nijman M AD - Department of Neonatology, Division Woman & Baby, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands; Department of Pediatric Cardiology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands. FAU - Cromb, Daniel AU - Cromb D AD - Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. FAU - Uus, Alena AU - Uus A AD - Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK; Biomedical Engineering Department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. FAU - Counsell, Serena AU - Counsell S AD - Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, UK. FAU - Bekker, Mireille N AU - Bekker MN AD - Department of Obstetrics, Division Woman & Baby, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. FAU - Tataranno, Maria Luisa AU - Tataranno ML AD - Department of Neonatology, Division Woman & Baby, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. FAU - Hulshoff Pol, Hilleke E AU - Hulshoff Pol HE AD - Department of Experimental Psychology, Helmholtz Institute, Utrecht University, Utrecht, the Netherlands. FAU - de Zwarte, Sonja M C AU - de Zwarte SMC AD - Department of Developmental Psychology, Utrecht University, Utrecht, the Netherlands. FAU - Benders, Manon J N L AU - Benders MJNL AD - Department of Neonatology, Division Woman & Baby, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands. LA - eng PT - Comparative Study PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251203 PL - United States TA - Neuroimage JT - NeuroImage JID - 9215515 SB - IM MH - Humans MH - *Magnetic Resonance Imaging/methods/standards MH - Female MH - *Imaging, Three-Dimensional/methods MH - *Ultrasonography, Prenatal/methods/standards MH - Pregnancy MH - *Brain/diagnostic imaging/embryology/anatomy & histology MH - Adult MH - Infant, Newborn MH - Male MH - *Fetus/diagnostic imaging/anatomy & histology MH - Organ Size OTO - NOTNLM OT - Intracranial volume OT - Magnetic resonance imaging OT - Third trimester OT - Ultrasound COIS- Declaration of competing interest The authors declare no conflicts of interest. EDAT- 2025/12/06 00:32 MHDA- 2025/12/18 01:31 CRDT- 2025/12/05 19:35 PHST- 2025/08/10 00:00 [received] PHST- 2025/11/18 00:00 [revised] PHST- 2025/12/02 00:00 [accepted] PHST- 2025/12/18 01:31 [medline] PHST- 2025/12/06 00:32 [pubmed] PHST- 2025/12/05 19:35 [entrez] AID - S1053-8119(25)00636-6 [pii] AID - 10.1016/j.neuroimage.2025.121633 [doi] PST - ppublish SO - Neuroimage. 2025 Dec 15;324:121633. doi: 10.1016/j.neuroimage.2025.121633. Epub 2025 Dec 3. PMID- 41349008 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251205 LR - 20251209 IS - 2561-6722 (Electronic) IS - 2561-6722 (Linking) VI - 8 DP - 2025 Dec 5 TI - Moderators of a mHealth Intervention for Adolescent Physical Activity: Intervention Refinement Study. PG - e59334 LID - 10.2196/59334 [doi] LID - e59334 AB - BACKGROUND: An adaptive text messaging intervention to promote adolescent physical activity has demonstrated feasibility, acceptability, and preliminary efficacy in a recent proof-of-concept study. To inform future intervention development, a secondary analysis of the data examined how physical activity is influenced by mood, environment, and physical feelings of energy and fatigue. OBJECTIVE: This study aims to understand how both macro- and microtemporal variables (eg, psychological and environmental variables at both levels) influence the efficacy of a brief mobile health intervention (ie, NUDGE) for physical activity. METHODS: Using a matched control design, we evaluated the effect of daily positive and negative affect, perceptions of the weather, energy, and fatigue as moderators of the effect of the intervention on 21 intervention participants and 21 matched controls. RESULTS: Consistent with study hypotheses, macrotemporal (levels of the variable on a 3-week timescale) moderators of intervention effectiveness were observed for positive affect (P<.001), negative affect (P=.03), energy (P<.001), fatigue (P<.001), and perceived weather barriers (P<.001) for moderate-to-vigorous physical activity. These effects were observed more consistently for moderate-to-vigorous physical activity than for sedentary behavior, which was only significant for energy (P<.001). No effects for microtemporal variables (at the day level) were observed. CONCLUSIONS: There appears to be an optimization opportunity for mobile health physical activity interventions that can be achieved by personalizing intervention features and content based on approximately monthly assessments of affect, physical feeling states, and perceived weather barriers. CI - (c) Christopher C Cushing, Adrian Ortega, David A Fedele, Calissa J Leslie-Miller, Jordan A Carlson, Ann M Davis, Joshua M Smyth. Originally published in JMIR Pediatrics and Parenting (https://pediatrics.jmir.org). FAU - Cushing, Christopher C AU - Cushing CC AUID- ORCID: 0000-0001-8452-8096 AD - Department of Clinical Child Psychology and Life Span Institute, University of Kansas, 1000 Sunnyside Avenue, Lawrence, KS, 66045, United States, 1 7858640713. FAU - Ortega, Adrian AU - Ortega A AUID- ORCID: 0000-0003-1003-2156 AD - Division of Developmental and Behavioral Health and Center for Children's Healthy Lifestyle & Nutrition, Children's Mercy, Kansas City, MO, United States. AD - Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, United States. FAU - Fedele, David A AU - Fedele DA AUID- ORCID: 0000-0003-0896-910X AD - Nemours Children's Health, Jacksonville, FL, United States. FAU - Leslie-Miller, Calissa J AU - Leslie-Miller CJ AUID- ORCID: 0000-0003-2523-3911 AD - Department of Clinical Child Psychology and Life Span Institute, University of Kansas, 1000 Sunnyside Avenue, Lawrence, KS, 66045, United States, 1 7858640713. FAU - Carlson, Jordan A AU - Carlson JA AUID- ORCID: 0000-0002-6008-7983 AD - Center for Children's Healthy Lifestyles & Nutrition, Children's Mercy, Kansas City, MO, United States. FAU - Davis, Ann M AU - Davis AM AUID- ORCID: 0000-0003-4859-5894 AD - Department of Pediatrics, Division of Developmental and Behavioral Pediatrics, Center for Children's Healthy Lifestyles & Nutrition, University of Kansas Medical Center, Kansas City, KS, United States. FAU - Smyth, Joshua M AU - Smyth JM AUID- ORCID: 0000-0002-0904-5390 AD - Department of Psychology, The Ohio State University, Columbus, OH, United States. LA - eng PT - Journal Article DEP - 20251205 PL - Canada TA - JMIR Pediatr Parent JT - JMIR pediatrics and parenting JID - 101727244 PMC - PMC12680371 OTO - NOTNLM OT - adolescent OT - acceptability OT - adaptive intervention OT - adolescent well-being OT - energy OT - exercise OT - fatigue OT - feasibility OT - mHealth OT - mobile health OT - mood OT - nudge OT - optimization OT - personalized OT - physical activity OT - teen OT - teenager OT - text message OT - text messaging OT - youth COIS- Conflicts of Interest: CCC has received consulting fees from PepsiCo and speaker/consulting fees from Cincinnati Children's Hospital Medical Center. EDAT- 2025/12/05 19:00 MHDA- 2025/12/05 19:01 PMCR- 2025/12/05 CRDT- 2025/12/05 16:42 PHST- 2024/04/09 00:00 [received] PHST- 2025/05/19 00:00 [revised] PHST- 2025/05/20 00:00 [accepted] PHST- 2025/12/05 19:01 [medline] PHST- 2025/12/05 19:00 [pubmed] PHST- 2025/12/05 16:42 [entrez] PHST- 2025/12/05 00:00 [pmc-release] AID - v8i1e59334 [pii] AID - 59334 [pii] AID - 10.2196/59334 [doi] PST - epublish SO - JMIR Pediatr Parent. 2025 Dec 5;8:e59334. doi: 10.2196/59334. PMID- 41348802 OWN - NLM STAT- MEDLINE DCOM- 20251205 LR - 20251208 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 12 DP - 2025 TI - The triple burden of malnutrition among adolescents in Dar es Salaam, Tanzania: The role of gender, household environment, and food insecurity. PG - e0337102 LID - 10.1371/journal.pone.0337102 [doi] LID - e0337102 AB - BACKGROUND: Adolescence is a critical growth period with increased nutritional needs that can put adolescents at risk for the triple burden of malnutrition, which can impair brain development, reduce functional capacity, and heighten the risk of non-communicable diseases. Despite this, there is limited data on factors associated with adolescent malnutrition in Dar es Salaam. This study aimed to determine the prevalence and associated factors for anaemia, stunting, underweight and overweight/obesity among adolescents in Dar es Salaam. METHODS: A cross-sectional study was conducted among 507 adolescents aged 12-19 in Dar es Salaam, using multistage cluster sampling. Data was collected using a pre-validated structured questionnaire through an Open Data Kit, while anthropometric measurements were measured using a digital weighing scale and stadiometer. Hemocue machines were utilised to measure anaemia through capillary blood samples. Data analysis, including descriptive statistics and modified Poisson regression, was performed using Stata v18 to identify factors associated with malnutrition. RESULTS: Overweight affected 16%, anaemia 39%, stunting 23% and thinness 12% of all adolescents. Food insecurity affected 69% of the households and was associated with a lower overweight risk (Crude Prevalence Ratio (CPR) 0.51, 95% CI: 0.34-0.75, p = 0.001) and a higher risk for thinness (CPR 2.10, 95% CI: 1.13, 3.91, p = 0.019). After controlling for other explanatory variables, adolescents from households with unimproved toilet facilities had a higher risk of anaemia (APR 1.51, 95% CI: 1.16-1.95, p = 0.002). Girls had a lower risk of stunting (APR 0.63, 95%, CI: 0.45-0.88, p = 0.006) and thinness (APR 0.29, 95%, CI: 0.16-0.54, p < 0.001) but a higher risk for overweight (APR 2.62, 95%, CI: 1.56-4.43, p < 0.001) compared to boys. CONCLUSION: Adolescents in Dar es Salaam experience high rates of malnutrition. Food insecurity, poor sanitation, and gender-specific factors contribute significantly to these outcomes. Integrated interventions are essential to address these interlinked determinants of malnutrition in this vulnerable group. CI - Copyright: (c) 2025 Kimaryo et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Kimaryo, Christina AU - Kimaryo C AUID- ORCID: 0009-0007-8025-7226 AD - Centre for International Health, University of Bergen, Bergen, Norway. FAU - Efraim, Josephine AU - Efraim J AD - Centre for International Health, University of Bergen, Bergen, Norway. FAU - Njenge, Nancy AU - Njenge N AD - Centre for International Health, University of Bergen, Bergen, Norway. FAU - Sunguya, Bruno AU - Sunguya B AD - Department of Community Health, School of Public Health and Social Sciences, Muhimbili University of Health and Allied Sciences, Dar es Salaam, Tanzania. FAU - Haskins, Lyn AU - Haskins L AD - Centre for Rural Health, University of KwaZulu-Natal, Durban, South Africa. FAU - Hatloy, Anne AU - Hatloy A AUID- ORCID: 0000-0002-3668-3216 AD - Centre for International Health, University of Bergen, Bergen, Norway. AD - Fafo Institute for Labour and Social Science, Oslo, Norway. FAU - Horwood, Christiane AU - Horwood C AD - Centre for Rural Health, University of KwaZulu-Natal, Durban, South Africa. LA - eng PT - Journal Article DEP - 20251205 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Adolescent MH - Tanzania/epidemiology MH - Male MH - Female MH - *Malnutrition/epidemiology MH - Cross-Sectional Studies MH - Child MH - *Food Insecurity MH - Prevalence MH - Thinness/epidemiology MH - Anemia/epidemiology MH - Overweight/epidemiology MH - Family Characteristics MH - Young Adult MH - Growth Disorders/epidemiology MH - Sex Factors PMC - PMC12680259 COIS- The authors have declared that no competing interests exist. EDAT- 2025/12/05 19:00 MHDA- 2025/12/05 19:01 PMCR- 2025/12/05 CRDT- 2025/12/05 13:46 PHST- 2025/03/13 00:00 [received] PHST- 2025/11/04 00:00 [accepted] PHST- 2025/12/05 19:01 [medline] PHST- 2025/12/05 19:00 [pubmed] PHST- 2025/12/05 13:46 [entrez] PHST- 2025/12/05 00:00 [pmc-release] AID - PONE-D-25-13116 [pii] AID - 10.1371/journal.pone.0337102 [doi] PST - epublish SO - PLoS One. 2025 Dec 5;20(12):e0337102. doi: 10.1371/journal.pone.0337102. eCollection 2025. PMID- 41348667 OWN - NLM STAT- MEDLINE DCOM- 20260323 LR - 20260323 IS - 1661-7819 (Electronic) IS - 1661-7800 (Linking) VI - 123 IP - 2 DP - 2026 TI - A B-Type Natriuretic Peptide-Based Machine Learning Model for Early Hemodynamic Symptomatic Patent Ductus Arteriosus Prediction. PG - 209-216 LID - 10.1159/000549577 [doi] AB - INTRODUCTION: Spontaneous ductal closure is common in preterm populations; however, a subset of infants develops a hemodynamically significant PDA (hsPDA), which has been associated with adverse outcomes. The objective was to develop and internally validate a predictive model for hsPDA in preterm infants using a machine learning approach. METHODS: A prospective cohort study including infants born at <33 weeks of gestation. B-type natriuretic peptide (BNP) levels within the first 120 h, gestational age, birth weight, and surfactant use were used to train a random forest classifier. The outcome was hsPDA diagnosed by standardized echocardiography. Model performance was assessed using stratified 5-fold cross-validation. RESULTS: Sixty-seven infants were included; 46.3% had hsPDA. The random forest model achieved an area under the receiver operating characteristic curve (AUC) of 0.86, outperforming logistic regression using BNP alone (AUC 0.82). BNP was the strongest predictor (48% importance), followed by gestational age, birth weight, and surfactant use. CONCLUSION: A machine learning-based model combining BNP with clinical variables showed high accuracy in predicting hsPDA. The accompanying calculator may assist clinicians in early risk stratification, though external validation is required before clinical implementation. CI - (c) 2025 S. Karger AG, Basel. FAU - Cappellaro, Carolina R AU - Cappellaro CR AD - Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Newborn Section, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil. FAU - Procianoy, Guilherme S AU - Procianoy GS AD - Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Newborn Section, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil. FAU - Silveira, Rita C AU - Silveira RC AD - Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Newborn Section, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil. FAU - Saalfeld, Rafaela M AU - Saalfeld RM AD - Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Newborn Section, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil. FAU - Procianoy, Renato S AU - Procianoy RS AD - Department of Pediatrics, Universidade Federal do Rio Grande do Sul, Newborn Section, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil, rprocianoy@gmail.com. LA - eng PT - Journal Article DEP - 20251205 PL - Switzerland TA - Neonatology JT - Neonatology JID - 101286577 RN - 114471-18-0 (Natriuretic Peptide, Brain) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Machine Learning MH - *Natriuretic Peptide, Brain/blood MH - *Ductus Arteriosus, Patent/blood/diagnosis/physiopathology/diagnostic imaging MH - Infant, Newborn MH - Prospective Studies MH - Female MH - Male MH - Gestational Age MH - Infant, Premature MH - *Hemodynamics MH - ROC Curve MH - Birth Weight MH - Echocardiography MH - Predictive Value of Tests MH - Biomarkers/blood MH - Logistic Models OTO - NOTNLM OT - B-type natriuretic peptide OT - Echocardiography OT - Hemodynamically significant patent ductus arteriosus calculator OT - Machine learning OT - Symptomatic patent ductus arteriosus OT - Very preterm newborn EDAT- 2025/12/05 19:00 MHDA- 2026/03/23 19:54 CRDT- 2025/12/05 13:34 PHST- 2025/08/15 00:00 [received] PHST- 2025/11/11 00:00 [accepted] PHST- 2026/03/23 19:54 [medline] PHST- 2025/12/05 19:00 [pubmed] PHST- 2025/12/05 13:34 [entrez] AID - 000549577 [pii] AID - 10.1159/000549577 [doi] PST - ppublish SO - Neonatology. 2026;123(2):209-216. doi: 10.1159/000549577. Epub 2025 Dec 5. PMID- 41348659 OWN - NLM STAT- MEDLINE DCOM- 20260323 LR - 20260323 IS - 1661-7819 (Electronic) IS - 1661-7800 (Linking) VI - 123 IP - 2 DP - 2026 TI - Physiological Postnatal Weight Loss Nomograms in Exclusively Breastfed Healthy Infants (>/=36 Weeks) during Initial Birth Hospitalization from an Arid Region: A Prospective Cohort Study. PG - 217-224 LID - 10.1159/000549630 [doi] AB - INTRODUCTION: Postnatal weight loss in infants is physiological, but excessive loss predisposes for dehydration and other morbidities. Existing nomograms, primarily developed in temperate climates, may not apply to arid regions as environmental conditions influence weight loss patterns. This study aimed to develop hour-specific percentile nomograms for postnatal weight loss in exclusively breastfed, healthy infants (>/=36 weeks) from an arid region, facilitating early identification of those at risk of excessive loss. METHODS: A prospective cohort study was conducted between November 2021 and February 2023 at a tertiary center in Western India. Exclusively breastfed infants >/=36 weeks without major morbidities were enrolled and weighed twice daily until 100 h after birth or discharge. Infants with abnormal clinical/biochemical findings or requiring any milk supplementation were censored. Quantile regression was used to generate percentile curves for weight loss. RESULTS: Out of 2,458 enrolled infants, 29.6% got censored, so 1,730 (1,134 vaginal, 596 cesarean) were included in the final analysis, contributing to 10,346 weight measurements. Median weight loss was 7.4% for vaginal and 8.7% for cesarean births; >/=10% loss occurred in 9.4% and 22.4% of infants, respectively. Distinct patterns and nadirs were observed based on mode of delivery. Compared to existing nomograms, our data showed greater early weight loss but quicker recovery after 48 h. CONCLUSIONS: These nomograms provide region-specific reference standards for monitoring postnatal weight loss among exclusively breastfed infants in a semiarid to arid region, offering a basis for further validation in other arid settings globally. CI - (c) 2025 S. Karger AG, Basel. FAU - Kaur, Ramandeep AU - Kaur R AD - Department of Neonatology, All India Institute of Medical Sciences, Jodhpur, India. FAU - Gupta, Neeraj AU - Gupta N AD - Department of Neonatology, All India Institute of Medical Sciences, Jodhpur, India, neerajpgi@yahoo.co.in. FAU - Yadav, Bharti AU - Yadav B AD - Department of Paediatrics, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India. FAU - Chawla, Deepak AU - Chawla D AD - Department of Neonatology, Government Medical College and Hospital (GMCH), Chandigarh, India. FAU - Singh, Arun Kumarendu AU - Singh AK AD - Department of Neonatology, All India Institute of Medical Sciences, Jodhpur, India. FAU - Singh, Pratibha AU - Singh P AD - Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Jodhpur, India. FAU - Banerjee, Mithu AU - Banerjee M AD - Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, India. LA - eng PT - Journal Article DEP - 20251205 PL - Switzerland TA - Neonatology JT - Neonatology JID - 101286577 SB - IM MH - Humans MH - *Breast Feeding MH - Prospective Studies MH - Female MH - *Nomograms MH - Infant, Newborn MH - *Weight Loss/physiology MH - India MH - Male MH - Hospitalization MH - Infant OTO - NOTNLM OT - Cesarean births OT - Exclusive breastfeeding OT - Newborn weight loss OT - Nomograms OT - Vaginal births EDAT- 2025/12/05 19:00 MHDA- 2026/03/23 19:54 CRDT- 2025/12/05 13:34 PHST- 2025/08/18 00:00 [received] PHST- 2025/11/11 00:00 [accepted] PHST- 2026/03/23 19:54 [medline] PHST- 2025/12/05 19:00 [pubmed] PHST- 2025/12/05 13:34 [entrez] AID - 000549630 [pii] AID - 10.1159/000549630 [doi] PST - ppublish SO - Neonatology. 2026;123(2):217-224. doi: 10.1159/000549630. Epub 2025 Dec 5. PMID- 41348450 OWN - NLM STAT- MEDLINE DCOM- 20251205 LR - 20260817 IS - 2561-326X (Electronic) IS - 2561-326X (Linking) VI - 9 DP - 2025 Dec 5 TI - Inhibitory Control, Attentional Bias, and Palatable Food Consumption in Adolescents: A Laboratory Feasibility Randomized Controlled Trial. PG - e77579 LID - 10.2196/77579 [doi] LID - e77579 AB - BACKGROUND: Understanding relationships among inhibitory control, attentional bias to food cues, and food consumption in nonclinical adolescent samples can inform preventive efforts for disordered eating and associated health risks. OBJECTIVE: This pilot study conducted preliminary testing of an inhibitory control training intervention on attentional bias toward food cues, hedonic appetite, and food consumption, as well as examined inhibitory control's relationship with hedonic appetite, food consumption, binge eating, and cognitive restraint. METHODS: Participants (N=43; mean age 15.1, SD 1.7 years; 31/43, 72% female) were randomized to a food cue-specific go/no go inhibitory control training intervention or control group, took part in a laboratory "taste test," and completed surveys and a dietary recall. Additional data were collected for subsamples through an eye tracking task (15/43, 35%) and cognitive tasks (19/43, 44%). RESULTS: The go/no go intervention showed preliminary associations with attentional bias toward food cues. There were preliminary associations between inhibitory control and sugar consumption measured via dietary recall, binge eating symptoms, and cognitive restraint, which should be examined in a fully powered study. CONCLUSIONS: The role of inhibitory control should be examined in larger studies to inform strategies for promotion of healthy eating behavior and prevention of disordered eating in adolescents. CI - (c)Carolina M Bejarano, Adrian Ortega, Christopher C Cushing. Originally published in JMIR Formative Research (https://formative.jmir.org), 05.12.2025. FAU - Bejarano, Carolina M AU - Bejarano CM AUID- ORCID: 0000-0001-5647-2144 AD - Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States. AD - Department of Pediatrics, College of Medicine, University of Cincinnati, Cincinnati, OH, United States. FAU - Ortega, Adrian AU - Ortega A AUID- ORCID: 0000-0003-1003-2156 AD - Division of Developmental and Behavioral Health and Center for Children's Healthy Lifestyle & Nutrition, Children's Mercy Hospital, Kansas City, MO, United States. AD - Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, United States. FAU - Cushing, Christopher C AU - Cushing CC AUID- ORCID: 0000-0001-8452-8096 AD - Department of Clinical Child Psychology & Schiefelbusch Institute for Life Span Studies, University of Kansas, Lawrence, KS, United States. LA - eng PT - Journal Article PT - Randomized Controlled Trial PT - Research Support, Non-U.S. Gov't DEP - 20251205 PL - Canada TA - JMIR Form Res JT - JMIR formative research JID - 101726394 SB - IM MH - Humans MH - Female MH - Adolescent MH - Male MH - *Attentional Bias/physiology MH - *Inhibition, Psychological MH - Pilot Projects MH - Feasibility Studies MH - *Feeding Behavior/psychology MH - *Eating/psychology MH - Cues MH - *Adolescent Behavior/psychology PMC - PMC12717506 OTO - NOTNLM OT - adolescent OT - attentional bias OT - hedonic appetite OT - inhibitory control OT - palatable food COIS- Conflicts of Interest: CCC has received consulting funds and research support from PepsiCo. EDAT- 2025/12/05 13:07 MHDA- 2025/12/05 19:00 PMCR- 2025/12/05 CRDT- 2025/12/05 11:53 PHST- 2025/05/15 00:00 [received] PHST- 2025/10/10 00:00 [accepted] PHST- 2025/07/11 00:00 [revised] PHST- 2025/12/05 19:00 [medline] PHST- 2025/12/05 13:07 [pubmed] PHST- 2025/12/05 11:53 [entrez] PHST- 2025/12/05 00:00 [pmc-release] AID - v9i1e77579 [pii] AID - 10.2196/77579 [doi] PST - epublish SO - JMIR Form Res. 2025 Dec 5;9:e77579. doi: 10.2196/77579. PMID- 41347539 OWN - NLM STAT- MEDLINE DCOM- 20251229 LR - 20260610 IS - 1475-2727 (Electronic) IS - 1368-9800 (Print) IS - 1368-9800 (Linking) VI - 28 IP - 1 DP - 2025 Dec 5 TI - Burden of anthropometric failures and concordance of mid-upper arm circumference with weight for length z score in identifying malnutrition among under 2-year-old children in Southern India. PG - e210 LID - 10.1017/S1368980025101523 [doi] LID - e210 AB - OBJECTIVE: To assess anthropometric failure prevalence using a composite index of anthropometric failure and evaluate the concordance of mid-upper arm circumference (MUAC) with weight for length z score (WLZ) in identifying acute malnutrition in children. DESIGN: We used data from a pre-proof-of-concept (pre-POC) study conducted in 2022-2023. SETTING: The study was conducted in the Vellore district in Tamil Nadu, South India. PARTICIPANTS: We included all children aged 5-19 months who were pre-screened for the pre-POC study and had available data on weight, length, MUAC, date of birth and child sex. RESULTS: A total of 663 children were available for analysis, with a mean age of 11.4 months. The prevalence of underweight, stunting and wasting was 23.8 %, 24.3 % and 16.6 %, respectively. 36.7 % of the children had at least one form of anthropometric deficit, and 8.2 % showed severe deficits. We found a fair agreement between MUAC and WLZ values (kappa = 0.32) and a poor agreement of kappa = 0.19 and 0.10 with weight for age z score (WAZ) and length for age z score (LAZ), respectively. CONCLUSIONS: The prevalence of malnutrition remains a significant public health concern in South India, with rates consistent with previous literature. MUAC and WLZ cutoffs by the WHO identify different groups with acute malnutrition. Community-based studies using WLZ criteria can adopt screening with higher MUAC cutoffs, followed by WLZ or, alternatively, WAZ alone, as low WAZ covers most participants with low MUAC and WLZ, providing better feasibility. However, the optimal measurement for risk identification requires further exploration. FAU - Sasikumar, Midhun AU - Sasikumar M AUID- ORCID: 0009-0006-2357-0403 AD - Unit of Health Sciences, Faculty of Social Sciences, https://ror.org/033003e23Tampere University, Tampere, Finland. AD - Department of Community Medicine, https://ror.org/00c7kvd80Christian Medical College Vellore, Vellore, Tamil Nadu, India. FAU - Marconi, Sam AU - Marconi S AD - Department of Community Medicine, https://ror.org/00c7kvd80Christian Medical College Vellore, Vellore, Tamil Nadu, India. FAU - Hakola, Leena AU - Hakola L AD - Unit of Health Sciences, Faculty of Social Sciences, https://ror.org/033003e23Tampere University, Tampere, Finland. AD - Department of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland. FAU - Pandian, Sowndharya AU - Pandian S AD - Department of Community Medicine, https://ror.org/00c7kvd80Christian Medical College Vellore, Vellore, Tamil Nadu, India. FAU - Vasudevan, Akshaya AU - Vasudevan A AD - Department of Community Medicine, https://ror.org/00c7kvd80Christian Medical College Vellore, Vellore, Tamil Nadu, India. FAU - Miyandad, Zavid AU - Miyandad Z AD - Department of Community Medicine, https://ror.org/00c7kvd80Christian Medical College Vellore, Vellore, Tamil Nadu, India. FAU - Mohan, Venkata Raghava AU - Mohan VR AD - Department of Community Medicine, https://ror.org/00c7kvd80Christian Medical College Vellore, Vellore, Tamil Nadu, India. FAU - Virtanen, Suvi M AU - Virtanen SM AD - Unit of Health Sciences, Faculty of Social Sciences, https://ror.org/033003e23Tampere University, Tampere, Finland. AD - Department of Public Health, Finnish Institute for Health and Welfare, Helsinki, Finland. AD - Tampere University Hospital, Wellbeing Services County of Pirkanmaa, Tampere, Finland. AD - Center for Child Health Research, Tampere University and Tampere University Hospital, Tampere, Finland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251205 PL - England TA - Public Health Nutr JT - Public health nutrition JID - 9808463 SB - IM MH - Humans MH - India/epidemiology MH - Male MH - Female MH - *Arm/anatomy & histology MH - Infant MH - *Anthropometry/methods MH - Prevalence MH - *Body Weight MH - Body Height MH - Thinness/epidemiology/diagnosis MH - Growth Disorders/epidemiology/diagnosis MH - Wasting Syndrome/epidemiology/diagnosis MH - *Malnutrition/diagnosis/epidemiology PMC - PMC12809605 OTO - NOTNLM OT - Concordance OT - Mid-upper arm circumference OT - Moderate acute malnutrition OT - Pre-proof-of-concept study OT - Weight for length z score COIS- There are no conflicts of interest. EDAT- 2025/12/05 13:07 MHDA- 2025/12/29 13:02 PMCR- 2025/12/05 CRDT- 2025/12/05 06:22 PHST- 2025/12/29 13:02 [medline] PHST- 2025/12/05 13:07 [pubmed] PHST- 2025/12/05 06:22 [entrez] PHST- 2025/12/05 00:00 [pmc-release] AID - S1368980025101523 [pii] AID - 10.1017/S1368980025101523 [doi] PST - epublish SO - Public Health Nutr. 2025 Dec 5;28(1):e210. doi: 10.1017/S1368980025101523. PMID- 41346844 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251205 LR - 20251207 IS - 2159-2896 (Print) IS - 2159-2896 (Electronic) IS - 2159-2896 (Linking) VI - 20 IP - 12 DP - 2025 TI - Agreement of Clinical Grade and Laboratory Grade Force Plates for Countermovement Jump Metrics in Youth Athletes. PG - 1675-1683 LID - 10.26603/001c.147057 [doi] AB - BACKGROUND: Recent technological advances have led to the development of user-friendly force plate systems that provide clinicians with the ability to analyze movement with precision that was previously only available within a biomechanics laboratory. While this development is promising, there is limited evidence supporting the concurrent validity of the range of variables provided by these devices, making it difficult for clinicians to interpret how values obtained within a clinical environment compare to published research. PURPOSE: To compare the concurrent validity of specific performance metrics obtained during a countermovement (CMJ) jump between a clinical grade force plate system and a laboratory grade system. STUDY DESIGN: Laboratory Based Cohort Study. METHODS: Sixty youth basketball athletes performed a CMJ jump on a clinical grade and a laboratory grade force plate system. Raw data from each device was utilized to calculate the following measures: jump height, peak ground reaction force (GRF), eccentric rate of force development (RFD), and concentric and eccentric impulse. Wilcoxon signed-rank tests evaluated differences between measures. Spearman correlations and Bland-Altman plots analyzed the relationship and accuracy between devices across all measures. RESULTS: There were no statistically significant differences and good agreement between devices for jump height, peak GRF, and eccentric RFD (p>0.05, percent difference range -3.35% to 6.14%). Other measures of jump performance, including concentric RFD measures, eccentric impulse, and concentric impulse, were moderately to poorly correlated (R-value range 0.296-0.447) and significantly different (p<0.05) between devices. CONCLUSION: Measurements between the clinical grade and laboratory grade force plates for jump height, peak ground reaction force, and eccentric RFD were comparable and showed good agreement. Clinicians should exercise caution when comparing data related to impulse measures between these systems. LEVEL OF EVIDENCE: 3. CI - (c) The Author(s). FAU - Greenberg, Elliot AU - Greenberg E AD - Sports Medicine and Performance Center Children's Hospital of Philadelphia. ROR: https://ror.org/01z7r7q48 AD - Department of Orthopedic Surgery University of Pennsylvania. ROR: https://ror.org/00b30xv10 FAU - Greenberg, Eric AU - Greenberg E AD - Department of Physical Therapy New York Institute of Technology. ROR: https://ror.org/01bghzb51 FAU - Riesenberg, Joshua AU - Riesenberg J AD - Orthopaedic and Sports Medicine Center Texas Scottish Rite Hospital for Children. ROR: https://ror.org/03gd5jm66 FAU - Graci, Valentina AU - Graci V AD - Center for Injury Research and Prevention Children's Hospital of Philadelphia. ROR: https://ror.org/01z7r7q48 AD - School of Biomedical Engineering, Science and Health Systems Drexel University. ROR: https://ror.org/04bdffz58 FAU - Ulman, Sophia AU - Ulman S AD - Orthopaedic and Sports Medicine Center Texas Scottish Rite Hospital for Children. ROR: https://ror.org/03gd5jm66 AD - Department of Orthopedic Surgery The University of Texas Southwestern Medical Center. ROR: https://ror.org/05byvp690 LA - eng PT - Journal Article DEP - 20251201 PL - United States TA - Int J Sports Phys Ther JT - International journal of sports physical therapy JID - 101553140 PMC - PMC12673951 OTO - NOTNLM OT - countermovement jump OT - force plates OT - method comparison OT - validity COIS- The authors report no conflicts of interest. EDAT- 2025/12/05 06:27 MHDA- 2025/12/05 06:28 PMCR- 2025/12/01 CRDT- 2025/12/05 04:31 PHST- 2025/06/18 00:00 [received] PHST- 2025/10/10 00:00 [accepted] PHST- 2025/12/05 06:28 [medline] PHST- 2025/12/05 06:27 [pubmed] PHST- 2025/12/05 04:31 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - 147057 [pii] AID - 10.26603/001c.147057 [doi] PST - epublish SO - Int J Sports Phys Ther. 2025 Dec 1;20(12):1675-1683. doi: 10.26603/001c.147057. eCollection 2025. PMID- 41346680 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251205 LR - 20251207 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Plant-based proteins for infant formula: findings and recommendations from the ILSI Europe workshop. PG - 1677243 LID - 10.3389/fnut.2025.1677243 [doi] LID - 1677243 AB - This Review Article summarizes outcomes from the ILSI Europe expert workshop on plant-based proteins in infant formula, held in November 2024. Experts from academia, clinical nutrition, and food science evaluated the current use and future potential of plant-based protein sources in infant formula, considering nutritional adequacy, allergenicity, sustainability, processing technologies, and regulatory constraints. While soy and hydrolyzed rice proteins are already approved and in use, emerging sources such as pea, lentil, and faba beans show promise but require further validation of their amino acid profiles, digestibility, safety, and suitability for infants. Key research priorities identified include the development of improved protein extraction methods, in vitro digestion and allergy modeling, and targeted clinical studies. This review synthesizes current evidence and expert perspectives to support the development of sustainable, nutritionally adequate plant-based infant formulas. CI - Copyright (c) 2025 Hettinga, van den Akker, Billecke, Cardinaals, Chang, Dupont, Furber, Grimshaw, Hallam, de Jong, Keppler, van Loo-Bouwman, Mersh, Mulder, Oliveros, Ozanne, Petersen, Tome, Vandenplas, van de Velde and Verbruggen. FAU - Hettinga, Kasper A AU - Hettinga KA AD - Food Quality & Design Group, Wageningen University & Research, Wageningen, Netherlands. FAU - van den Akker, Chris H P AU - van den Akker CHP AD - Department of Pediatrics-Neonatology, Amsterdam UMC - Emma Children's Hospital, Amsterdam, Netherlands. FAU - Billecke, Nils AU - Billecke N AD - Cargill R&D Centre Europe BV, Vilvoorde, Belgium. FAU - Cardinaals, Renee AU - Cardinaals R AD - Earth Systems and Global Change Group, Wageningen University & Research, Wageningen, Netherlands. FAU - Chang, Ching-Yu AU - Chang CY AD - International Life Science Institute European Branch, Brussels, Belgium. FAU - Dupont, Didier AU - Dupont D AD - INRAE l'Institut Agro, STLO, Rennes, France. FAU - Furber, Matthew AU - Furber M AD - Danone Research & Innovation, Utrecht, Netherlands. FAU - Grimshaw, Kate AU - Grimshaw K AD - Manchester Metropolitan University, Manchester, United Kingdom. AD - Northern Care Alliance NHS Foundation Trust, Manchester, United Kingdom. FAU - Hallam, Paula AU - Hallam P AD - Tiny Tots Nutrition, London, United Kingdom. FAU - de Jong, Peter AU - de Jong P AD - Van Hall Larenstein University of Applied Sciences, Leeuwarden, Netherlands. AD - NIZO Food Research B.V., Ede, Netherlands. FAU - Keppler, Julia K AU - Keppler JK AD - Laboratory of Food Process Engineering, Wageningen University & Research, Wageningen, Netherlands. FAU - van Loo-Bouwman, Carolien A AU - van Loo-Bouwman CA AD - Yili Innovation Center Europe, Wageningen, Netherlands. FAU - Mersh, Cath AU - Mersh C AD - Cath Mersh Communications, Aarhus, Denmark. FAU - Mulder, Kelly A AU - Mulder KA AD - Danone Research & Innovation, Utrecht, Netherlands. FAU - Oliveros, Elena AU - Oliveros E AD - Abbott, Granada, Spain. FAU - Ozanne, Susan AU - Ozanne S AD - Department of Clinical Biochemistry, Cambridge University, Cambridge, United Kingdom. FAU - Petersen, Iben Lykke AU - Petersen IL AD - Department of Food Science, University of Copenhagen, Copenhagen, Denmark. FAU - Tome, Daniel AU - Tome D AD - AgroParisTech, Universite Paris-Saclay, Paris, France. FAU - Vandenplas, Yvan AU - Vandenplas Y AD - KidZ Health Castle, UZ Brussel, Brussels, Belgium. FAU - van de Velde, Fred AU - van de Velde F AD - NIZO Food Research B.V., Ede, Netherlands. FAU - Verbruggen, Sascha C A T AU - Verbruggen SCAT AD - Department of Neonatal and Pediatric Intensive Care, Erasmus MC Sophia Children's Hospital, Rotterdam, Netherlands. LA - eng PT - Journal Article PT - Review DEP - 20251119 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12673664 OTO - NOTNLM OT - food regulation OT - infant formula OT - nutritional adequacy OT - pediatric nutrition OT - plant-based proteins OT - protein quality OT - sustainability COIS- NB was employed by Cargill R&D Centre Europe BVBA. MF and KM were employed by Danone Research & Innovation. PH is the founder of Tiny Tots Nutrition. PJ and FV were employed by NIZO Food Research B.V. CL-B was employed by Yili Innovation Center Europe. CM is the founder of Cath Mersh Communications and received funding for her writing services from the above-mentioned Task Forces. EO was employed by Abbott Laboratories S.A. KH, CA, RC, DD, PH, PJ, JK, SO, IP, DT, YV, FV, and SV received travel and accommodation costs from the Early Nutrition and Long-Term Health Task Force to attend workshops/meetings to discuss the manuscript. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/05 06:27 MHDA- 2025/12/05 06:28 PMCR- 2025/11/19 CRDT- 2025/12/05 04:28 PHST- 2025/07/31 00:00 [received] PHST- 2025/10/17 00:00 [accepted] PHST- 2025/12/05 06:28 [medline] PHST- 2025/12/05 06:27 [pubmed] PHST- 2025/12/05 04:28 [entrez] PHST- 2025/11/19 00:00 [pmc-release] AID - 10.3389/fnut.2025.1677243 [doi] PST - epublish SO - Front Nutr. 2025 Nov 19;12:1677243. doi: 10.3389/fnut.2025.1677243. eCollection 2025. PMID- 41346195 OWN - NLM STAT- MEDLINE DCOM- 20260521 LR - 20260813 IS - 1941-2452 (Electronic) IS - 0884-5336 (Print) IS - 0884-5336 (Linking) VI - 41 IP - 3 DP - 2026 Jun TI - Development and validation of a nutrition risk screening for patients with childhood cancer in Brazil (NUTRICCAN). PG - 768-778 LID - 10.1002/ncp.70076 [doi] AB - BACKGROUND: Diagnosing malnutrition in patients with pediatric cancer is challenging because tumor masses can interfere with anthropometric measurements. STRONGkids considers cancer a general risk factor, whereas Screening Tool for Childhood Cancer (SCAN) classifies patients as at risk or not, potentially missing those who need nutrition monitoring. This study describes development and validation of a new nutrition risk screening tool for childhood cancer in Brazil. METHODS: Nutrition Risk Screening for Childhood Cancer (NUTRICCAN) underwent online expert content validation. Twelve nutritionists applied it to oncology inpatients (0-19 years old) at the Pediatric Oncology Institute at Federal University of Sao Paulo from June to August 2024. Nutrition risk was assessed using NUTRICCAN, STRONGkids, and SCAN. Logistic regression identified screening variables associated with malnutrition (body mass index-for-age z score < -2, mid-upper arm circumference [MUAC] <5(th) percentile, calf circumference below cutoff, or met any of the criteria for malnutrition). Receiver operating characteristic analysis determined cutoff scores, and sensitivity/specificity analyses allowed comparisons among instruments. RESULTS: Patients not receiving intensive care were almost three times more likely to have an inadequate MUAC (odds ratio [OR], 4.505; 95% confidence interval [CI], 1.446-14.033; P = 0.009). Low socioeconomic status or caregiver education increased the risk of malnutrition (OR, 2.845; 95% CI, 1.070-7.566; P = 0.036). Dietitians' subjective assessments were associated with a fourfold increased risk of malnutrition. NUTRICCAN was 70% accurate (area under the curve, 0.701; 95% CI, 0.617-0.785), outperforming the other tools. CONCLUSION: NUTRICCAN better stratifies nutritional risk, considering clinical and socioeconomic factors, and may allow for more targeted interventions, especially in resource-limited settings. CI - (c) 2025 The Author(s). Nutrition in Clinical Practice published by Wiley Periodicals LLC on behalf of American Society for Parenteral and Enteral Nutrition. FAU - Marcon, Cristiane Ferreira AU - Marcon CF AUID- ORCID: 0000-0002-3819-9081 AD - Postgraduate Program in Nutrition, Federal University of Sao Paulo, Sao Paulo, Brazil. FAU - Santos, Carolina Araujo Dos AU - Santos CAD AD - Department of Nutrition and Health, Federal University of Vicosa, Vicosa, Minas Gerais, Brazil. FAU - Oliveira, Fernanda Luisa Ceragioli AU - Oliveira FLC AD - Postgraduate Program in Nutrition, Federal University of Sao Paulo, Sao Paulo, Brazil. AD - Department of Pediatrics, Discipline of Pediatric Nutrology, Escola Paulista de Medicina Federal, University of Sao Paulo, Sao Paulo, Brazil. LA - eng GR - None/ PT - Journal Article PT - Validation Study DEP - 20251204 PL - United States TA - Nutr Clin Pract JT - Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition JID - 8606733 SB - IM MH - Humans MH - Brazil/epidemiology MH - Child MH - Child, Preschool MH - *Nutrition Assessment MH - Adolescent MH - Female MH - Male MH - Infant MH - *Malnutrition/diagnosis/etiology MH - *Neoplasms/complications MH - Young Adult MH - Risk Factors MH - Nutritional Status MH - *Mass Screening/methods MH - Risk Assessment/methods MH - ROC Curve MH - Infant, Newborn MH - Sensitivity and Specificity MH - Logistic Models MH - Reproducibility of Results PMC - PMC13193373 OTO - NOTNLM OT - life cycle OT - nutrition OT - nutrition assessment OT - oncology OT - pediatrics OT - research and diseases COIS- None declared. EDAT- 2025/12/05 06:27 MHDA- 2026/05/21 12:38 PMCR- 2026/05/21 CRDT- 2025/12/05 02:32 PHST- 2025/10/29 00:00 [revised] PHST- 2025/03/16 00:00 [received] PHST- 2025/11/05 00:00 [accepted] PHST- 2026/05/21 12:38 [medline] PHST- 2025/12/05 06:27 [pubmed] PHST- 2025/12/05 02:32 [entrez] PHST- 2026/05/21 00:00 [pmc-release] AID - NCP70076 [pii] AID - 10.1002/ncp.70076 [doi] PST - ppublish SO - Nutr Clin Pract. 2026 Jun;41(3):768-778. doi: 10.1002/ncp.70076. Epub 2025 Dec 4. PMID- 41346036 OWN - NLM STAT- MEDLINE DCOM- 20260102 LR - 20260919 IS - 1469-0705 (Electronic) IS - 0960-7692 (Print) IS - 0960-7692 (Linking) VI - 67 IP - 1 DP - 2026 Jan TI - Adverse perinatal outcomes in twins: comparison of intertwin fetal size discordance vs singleton and twin fetal growth charts. PG - 42-48 LID - 10.1002/uog.70139 [doi] AB - OBJECTIVE: To compare the predictive performance of intertwin estimated fetal weight (EFW) discordance and EFW centile calculated according to either the Fetal Medicine Foundation (FMF) singleton or twin-specific fetal growth charts for adverse perinatal outcome in dichorionic and monochorionic twin pregnancies. METHODS: This was a retrospective multicenter cohort study of twin pregnancies managed between January 2013 and December 2023 at three tertiary fetal medicine centers in the UK, Italy and Belgium. Twin pregnancies in which an obstetric ultrasound exam was performed to obtain fetal biometry within 2 weeks before live birth or diagnosis of intrauterine fetal demise of one or both twins were included. Cases with anastomotic complications were excluded. The primary outcome was a composite adverse perinatal outcome (CAPO), defined as stillbirth (intrauterine fetal demise >/= 22 weeks) of at least one cotwin and/or iatrogenic early preterm birth (delivery < 34 weeks) for fetal indications. The predictive performance of intertwin EFW discordance and of the EFW centile of the smaller twin, calculated using either singleton or twin-specific FMF fetal growth charts, was assessed for CAPO. Predictive models were developed using logistic regression analysis and evaluated using the area under the receiver-operating-characteristics curve (AUC); pairwise comparisons between models were performed using DeLong's test. RESULTS: The study analyzed 1294 dichorionic and 487 monochorionic twin pregnancies. For the prediction of CAPO, intertwin EFW discordance in dichorionic twins achieved an AUC of 0.93 (95% CI, 0.89-0.98), compared with 0.83 (95% CI, 0.77-0.90) (P = 0.001) and 0.87 (95% CI, 0.81-0.93) (P = 0.017) for EFW centile based on singleton and twin-specific growth charts, respectively. Likewise, intertwin EFW discordance achieved an AUC of 0.95 (95% CI, 0.92-0.97) for predicting CAPO in monochorionic twins, outperforming EFW centile based on singleton charts (AUC, 0.80 (95% CI, 0.73-0.87); P < 0.001) and twin-specific growth charts (AUC, 0.83 (95% CI, 0.76-0.90); P < 0.001). In clinical terms, at a 20% false-positive rate (FPR), the sensitivity for CAPO in dichorionic twin pregnancies was 74%, 81% and 93% using singleton charts, twin-specific charts and intertwin EFW discordance, respectively. Similarly, in monochorionic twin pregnancies, the sensitivity at a FPR of 20% was 75%, 79% and 98% using singleton charts, twin-specific charts and intertwin EFW discordance, respectively. CONCLUSIONS: Intertwin EFW discordance is a more reliable predictor of the composite outcome of stillbirth in at least one cotwin and/or iatrogenic early preterm birth in twin pregnancies than is EFW centile based on either singleton or twin-specific growth charts. This approach addresses the limitations of using different fetal growth reference charts that rely on arbitrary cut-offs. Following external validation, the use of intertwin EFW discordance prediction algorithms may potentially enhance risk stratification to improve clinical outcomes in twin pregnancies. (c) 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. CI - (c) 2025 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology. FAU - Giorgione, V AU - Giorgione V AUID- ORCID: 0000-0003-3991-9308 AD - Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK. FAU - Lopian, M AU - Lopian M AUID- ORCID: 0000-0001-5304-2296 AD - Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK. FAU - Trapani, M AU - Trapani M AD - Department of Women and Child Health, Women Health Area, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. FAU - Brutto, M AU - Brutto M AD - Department of Women and Child Health, Women Health Area, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. FAU - Ferrante, M G AU - Ferrante MG AD - Department of Women and Child Health, Women Health Area, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. FAU - Bhide, A AU - Bhide A AUID- ORCID: 0000-0003-2393-7501 AD - Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK. AD - Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK. FAU - Jani, J C AU - Jani JC AD - Department of Obstetrics and Gynecology, University Hospital Brugmann, Universite Libre de Bruxelles, Brussels, Belgium. FAU - Badr, D A AU - Badr DA AD - Department of Obstetrics and Gynecology, University Hospital Brugmann, Universite Libre de Bruxelles, Brussels, Belgium. FAU - Ghi, T AU - Ghi T AD - Department of Women and Child Health, Women Health Area, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. AD - Catholic University of the Sacred Heart, Rome, Italy. FAU - Bevilacqua, E AU - Bevilacqua E AUID- ORCID: 0000-0002-9791-9552 AD - Department of Women and Child Health, Women Health Area, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. FAU - Familiari, A AU - Familiari A AD - Department of Women and Child Health, Women Health Area, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy. AD - Catholic University of the Sacred Heart, Rome, Italy. FAU - Thilaganathan, B AU - Thilaganathan B AUID- ORCID: 0000-0002-5531-4301 AD - Fetal Medicine Unit, St George's University Hospitals NHS Foundation Trust, London, UK. AD - Vascular Biology Research Centre, Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK. LA - eng PT - Comparative Study PT - Journal Article PT - Multicenter Study DEP - 20251204 PL - England TA - Ultrasound Obstet Gynecol JT - Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology JID - 9108340 SB - IM MH - Humans MH - Pregnancy MH - Female MH - Retrospective Studies MH - *Pregnancy, Twin/statistics & numerical data MH - *Ultrasonography, Prenatal/methods MH - *Growth Charts MH - *Fetal Weight MH - Adult MH - *Fetal Development/physiology MH - *Fetal Growth Retardation/diagnostic imaging MH - Predictive Value of Tests MH - Infant, Newborn MH - Pregnancy Outcome/epidemiology MH - Gestational Age MH - Italy/epidemiology MH - Belgium/epidemiology MH - United Kingdom/epidemiology MH - Stillbirth/epidemiology PMC - PMC12757814 OTO - NOTNLM OT - adverse perinatal outcome OT - estimated fetal weight OT - fetal growth reference standards OT - fetal growth restriction OT - intertwin size discordance OT - middle cerebral artery OT - stillbirths OT - twins OT - umbilical artery EDAT- 2025/12/05 06:27 MHDA- 2026/01/02 06:28 PMCR- 2026/01/02 CRDT- 2025/12/05 01:03 PHST- 2025/08/08 00:00 [revised] PHST- 2025/02/11 00:00 [received] PHST- 2025/10/02 00:00 [accepted] PHST- 2026/01/02 06:28 [medline] PHST- 2025/12/05 06:27 [pubmed] PHST- 2025/12/05 01:03 [entrez] PHST- 2026/01/02 00:00 [pmc-release] AID - UOG70139 [pii] AID - 10.1002/uog.70139 [doi] PST - ppublish SO - Ultrasound Obstet Gynecol. 2026 Jan;67(1):42-48. doi: 10.1002/uog.70139. Epub 2025 Dec 4. PMID- 41345984 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260108 LR - 20260505 IS - 2662-2211 (Electronic) IS - 2662-2211 (Linking) VI - 7 IP - 1 DP - 2025 Dec 4 TI - Enhancing intergenerational HeAlth in Nigeria: peripartum as Critical life stagE for CardioVascular Health (ENHANCE-CVH) study: findings from pre-implementation using the updated consolidated framework for implementation research (CFIR 2.0). PG - 5 LID - 10.1186/s43058-025-00816-8 [doi] LID - 5 AB - BACKGROUND: Pregnancy is a crucial period to improve cardiovascular health (CVH) for mothers and their families. The current study emphasizes framework-guided factors that influence the adaptation of an evidence-based intervention (Parents as Teachers and Healthy Eating Active Living Taught at Home [PAT + HEALTH]) to support healthy gestational weight gain and postpartum weight management among pregnant women with obesity and their infants in Nigeria. METHODS: From May to June 2023, 43 in-depth interviews were conducted with 11 parents, 15 community health extension workers (CHEWs)/health educators, and 17 policymakers/ healthcare supervisors in the Federal Capital Territory, Nigeria. Additionally, nine focus groups were conducted with 75 participants. Interviews were recorded, de-identified, and transcribed. The updated Consolidated Framework for Implementation Research (CFIR 2.0) informed the development of the interview guides and the thematic analysis. Transcripts were double-coded using Dedoose. RESULTS: We identified assessing context, tailoring strategies, local attitudes, and sustainability as constructs to consider when adapting and implementing the PAT + HEALTH intervention successfully within the Nigerian primary care context. For example, policymakers and healthcare supervisors emphasized the feasibility of the intervention, including raising community awareness, planning for hard-to-reach areas, and ensuring supportive supervision of CHEWs delivering the intervention. Additional factors included customizing educational content and delivery methods to fit the cultural, socioeconomic, and environmental contexts of Nigerian families. CHEWs highlighted the importance of public education on locally available foods for better nutrition. Potential barriers to the PAT + HEALTH intervention included local attitudes influenced by sociocultural factors, such as food taboos, and structural factors, including limited financial support for the long-term sustainability of some components of the home visiting program. CONCLUSIONS: Building on these formative activities, the ENHANCE CVH trial will advance dissemination and implementation science by adapting, testing, and evaluating the effectiveness and implementation of the PAT + HEALTH intervention among pregnant women with obesity and their infants in Nigeria in a cluster randomized trial. TRIAL REGISTRATION: ClinicalTrials.gov/NCT06773299, Registration Date: January 14, 2025. CI - (c) 2025. The Author(s). FAU - Lopez, Julia D AU - Lopez JD AUID- ORCID: 0000-0002-8197-002X AD - Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, 4523 Clayton Avenue, St. Louis, USA. julialopez@wustl.edu. AD - School of Public Health, Washington University in St. Louis, St. Louis, MO, USA. julialopez@wustl.edu. FAU - Aifah, Angela AU - Aifah A AD - Institute for Excellence in Health Equity & Department of Population Health, NYU Grossman School of Medicine, New York, NY, USA. FAU - Nartey, Cecilia AU - Nartey C AD - Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. FAU - Ripiye, Nanna R AU - Ripiye NR AD - Cardiovascular Research Unit, University of Abuja and University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria. FAU - Shedul, Gabriel L AU - Shedul GL AD - Cardiovascular Research Unit, University of Abuja and University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria. FAU - Okpetu, Emmanuel AU - Okpetu E AD - Cardiovascular Research Unit, University of Abuja and University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria. FAU - Nwaozuru, Ucheoma C AU - Nwaozuru UC AD - Department of Implementation Science, Wake Forest University School of Medicine, Winston-Salem, NC, USA. FAU - Aluka-Omitiran, Kasarachi AU - Aluka-Omitiran K AD - Cardiovascular Research Unit, University of Abuja and University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria. FAU - Onwu, Nneka AU - Onwu N AD - Africa Saving Lives Konsult, Garki, Abuja, Nigeria. FAU - Obiezu-Umeh, Chisom AU - Obiezu-Umeh C AD - Department of Medical Social Sciences, Center for Dissemination and Implementation Science, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. FAU - Marshall, Tiedra AU - Marshall T AD - Parents As Teachers National Center, St. Louis, MO, USA. FAU - Kemner, Allison AU - Kemner A AD - Parents As Teachers National Center, St. Louis, MO, USA. FAU - Lindley, Kathryn J AU - Lindley KJ AD - Department of Medicine, Cardiovascular Division, Vanderbilt University Medical Center, Nashville, TN, USA. FAU - Haire-Joshu, Debra AU - Haire-Joshu D AD - School of Public Health, Washington University in St. Louis, St. Louis, MO, USA. FAU - Davila-Roman, Victor G AU - Davila-Roman VG AD - School of Public Health, Washington University in St. Louis, St. Louis, MO, USA. AD - Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. FAU - Akaba, Godwin AU - Akaba G AD - Cardiovascular Research Unit, University of Abuja and University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria. FAU - Huffman, Mark D AU - Huffman MD AD - School of Public Health, Washington University in St. Louis, St. Louis, MO, USA. AD - Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. AD - The George Institute for Global Health, UNSW, Sydney, Australia. FAU - Ojji, Dike B AU - Ojji DB AD - Cardiovascular Research Unit, University of Abuja and University of Abuja Teaching Hospital, Gwagwalada, Abuja, Nigeria. AD - Department of Internal Medicine, Faculty of Clinical Sciences, University of Abuja, Abuja, Nigeria. FAU - Okoro, Clementina E AU - Okoro CE AD - Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, USA. CN - ENHANCE C. V. H. Investigators LA - eng SI - ClinicalTrials.gov/NCT06773299 GR - P30 DK092950/DK/NIDDK NIH HHS/United States GR - R01 HL168771/HL/NHLBI NIH HHS/United States GR - 1K01HL165086-01A1/HL/NHLBI NIH HHS/United States GR - K01 HL165086/HL/NHLBI NIH HHS/United States GR - R01HL168771/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20251204 PL - England TA - Implement Sci Commun JT - Implementation science communications JID - 101764360 PMC - PMC12781714 OTO - NOTNLM OT - Cardiovascular health OT - Consolidated Framework for Implementation Research OT - Home visiting program OT - Nigeria OT - Obesity OT - Parents as Teachers OT - Pre-implementation process OT - Pregnant women COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Washington University in St. Louis and the University of Abuja Teaching Hospitals' applicable institutional review boards and ethics committees. Prior to data collection, written informed consent was obtained from the study patients and providers. Consent for publication: All authors have reviewed and approved the final version of the manuscript and consent to its submission and publication. Competing interests: MDH has received travel support from the World Heart Federation and consulting fees from PwC Switzerland. MDH has an appointment at The George Institute for Global Health, which has a patent, license, and has received investment funding with intent to commercialize fixed-dose combination therapy through its social enterprise business, George Medicines. MDH has pending patents for heart failure polypills. The other authors declare that they have no competing interests. EDAT- 2025/12/05 06:27 MHDA- 2025/12/05 06:28 PMCR- 2025/12/04 CRDT- 2025/12/05 00:26 PHST- 2025/02/07 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2025/12/05 06:28 [medline] PHST- 2025/12/05 06:27 [pubmed] PHST- 2025/12/05 00:26 [entrez] PHST- 2025/12/04 00:00 [pmc-release] AID - 10.1186/s43058-025-00816-8 [pii] AID - 816 [pii] AID - 10.1186/s43058-025-00816-8 [doi] PST - epublish SO - Implement Sci Commun. 2025 Dec 4;7(1):5. doi: 10.1186/s43058-025-00816-8. PMID- 41345805 OWN - NLM STAT- MEDLINE DCOM- 20251205 LR - 20260919 IS - 1432-1076 (Electronic) IS - 0340-6199 (Print) IS - 0340-6199 (Linking) VI - 184 IP - 12 DP - 2025 Dec 5 TI - The triglyceride glucose index as a biomarker for different glucose disorders in overweight and obese children and adolescents. PG - 820 LID - 10.1007/s00431-025-06632-5 [doi] LID - 820 AB - The triglyceride/glucose index (TyG index), a formula derived from fasting triglyceride (TG) and glucose levels, has emerged as a simple and reliable alternative marker for estimating insulin resistance (IR). This study aimed to evaluate the potential utility of the TyG index in predicting different glucose disorders (GD) in obese and overweight children. This prospective study included 60 children aged 5 to 15 years with overweight or obesity. They were divided into two equal groups: Group 1 consisted of children with obesity (BMI > 95th percentile), and Group 2 comprised overweight children (BMI 85th-95th percentile). The control group consisted of 30 healthy children with normal BMI, matched for age and sex. TG, fasting blood glucose (FBG), oral glucose tolerance test, 2-h postprandial glucose, the TyG index, homeostatic model assessment for IR (HOMA-IR), and glycated hemoglobin (HbA1c) were measured in all participating children. TG, HbA1c, FBG, and the TyG index were significantly elevated in both groups 1 and 2 compared with the control group. There was a strong positive correlation between TyG index and (HbA1C, FBG, HOMA IR, and 2-h postprandial glucose). The TyG index demonstrated a strong predictive ability for type 2 diabetes, impaired glucose tolerance, impaired fasting glucose, and IR with cut-off values of 4.57, 4.52, 4.43, and 4.34, respectively. These cut-off values were associated with sensitivities of 100%, 100%, 88.9%, and 71.4%, and specificities of 95.3%, 95.1%, 88.3%, and 100%, respectively. CONCLUSION: The TyG index is a promising and reliable marker for detecting different glucose disorders in obese and overweight children. WHAT IS KNOWN: * The triglyceride/glucose index (TyG index), a formula derived from fasting triglyceride (TG) and glucose levels, has emerged as a simple and reliable alternative marker for estimating insulin resistance (IR) in pediatrics and adults. WHAT IS NEW: * We investigated, for the first time, the potential utility of the TyG index in predicting different glucose disorders (GD) such as type 2 diabetes mellitus (T2DM), impaired glucose tolerance, impaired fasting glucose as well as IR in obese and overweight children. * We found that the TyG index is a promising and reliable marker for detecting different glucose disorders in obese and overweight children. CI - (c) 2025. The Author(s). FAU - Taha, Ola AU - Taha O AD - Pediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt. FAU - Abdallah, Lobna AU - Abdallah L AD - Ministry of Health and Population, Tanta, Egypt. FAU - Erfan, Adel AU - Erfan A AD - Pediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt. FAU - Elsharaby, Radwa AU - Elsharaby R AD - Clinical Pathology Department, Faculty of Medicine, Tanta University, Tanta, Egypt. FAU - El Amrousy, Doaa AU - El Amrousy D AD - Pediatric Department, Faculty of Medicine, Tanta University, Tanta, Egypt. Doaa.moha@med.tanta.edu.eg. LA - eng PT - Journal Article DEP - 20251205 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 0 (Biomarkers) RN - 0 (Blood Glucose) RN - 0 (Triglycerides) RN - 0 (Glycated Hemoglobin) SB - IM MH - Humans MH - Child MH - Adolescent MH - Male MH - Female MH - Biomarkers/blood MH - *Blood Glucose/analysis/metabolism MH - *Triglycerides/blood MH - Prospective Studies MH - Insulin Resistance MH - *Pediatric Obesity/blood/complications MH - Child, Preschool MH - Glucose Tolerance Test MH - *Overweight/blood/complications MH - Case-Control Studies MH - *Glucose Metabolism Disorders/blood/diagnosis/etiology MH - Glycated Hemoglobin/analysis MH - Predictive Value of Tests PMC - PMC12678614 OTO - NOTNLM OT - Childhood OT - Impaired fasting glucose OT - Impaired glucose tolerance OT - Insulin resistance OT - Obesity OT - TyG index OT - Type 2 DM COIS- Declarations. Ethics approval: The study obtained ethical approval from the faculty of medicine's local Ethical Committee at Tanta University. The human subjects were enrolled following the principles of the Declaration of Helsinki. Consent to participate: Participants and their parents provided a written consent form. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/05 01:02 MHDA- 2025/12/05 06:27 PMCR- 2025/12/05 CRDT- 2025/12/04 23:53 PHST- 2025/08/24 00:00 [received] PHST- 2025/11/10 00:00 [accepted] PHST- 2025/11/05 00:00 [revised] PHST- 2025/12/05 06:27 [medline] PHST- 2025/12/05 01:02 [pubmed] PHST- 2025/12/04 23:53 [entrez] PHST- 2025/12/05 00:00 [pmc-release] AID - 10.1007/s00431-025-06632-5 [pii] AID - 6632 [pii] AID - 10.1007/s00431-025-06632-5 [doi] PST - epublish SO - Eur J Pediatr. 2025 Dec 5;184(12):820. doi: 10.1007/s00431-025-06632-5. PMID- 41344702 OWN - NLM STAT- MEDLINE DCOM- 20251204 LR - 20260106 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 12 DP - 2025 Dec 4 TI - Screen time and sleep problems in South Indian preschoolers: a community-based cross-sectional study. PG - e109376 LID - 10.1136/bmjopen-2025-109376 [doi] LID - e109376 AB - OBJECTIVES: To estimate the prevalence of sleep problems among children aged 2-5 years residing in South India, assess its association with screen time and identify a predictive screen time threshold. DESIGN: Population-based cross-sectional study. SETTING: Field practice areas in rural and urban centres of a medical college in South India. PARTICIPANTS: In total, 523 children aged 2-5 years were selected by simple random sampling. PRIMARY OUTCOME MEASURES: Sleep problems were assessed using the validated bedtime problems, excessive daytime sleepiness, awakenings during the night, regularity of sleep and snoring sleep screening tool. Sociodemographic and behavioural factors, including screen time, were also examined. The optimal predictive screen time cut-off was identified using receiver operating characteristic (ROC) analysis. RESULTS: Sleep disturbances were reported in 39.6% of children (95% CI 35.5% to 43.8%). The most common sleep problems were irregular sleep (22.2%), bedtime resistance (20.8%) and night awakening (19.9%). Multivariate logistic regression showed strong associations between sleep problems and screen use in bed (adjusted OR (AOR) = 3.8; 95% CI 2.4 to 6.1), excess screen time (AOR=3.3; 95% CI 1.8 to 6), smaller family size (AOR=3.1; 95% CI 1.5 to 6.1), reduced physical activity (AOR=2.6; 95% CI 1.6 to 4.2), shorter birth spacing (AOR=1.8; 95% CI 1.1 to 2.8), lower socioeconomic status (AOR=1.8; 95% CI 1.2 to 2.8) and maternal screen time>2 hours/day (AOR=1.6; 95% CI 1.04 to 2.6). ROC analysis identified >/=2.4 hours per day of screen time as the optimal threshold for predicting sleep problems (area under the curve=0.800; sensitivity, 73.9% and specificity, 77.2%). CONCLUSION: In this large population-based study, two of the five preschool children experienced sleep problems, with excess screen time, particularly screen use in bed, being the key contributing factor. This is one of the few Indian studies to establish an ROC-derived screen time threshold for identifying sleep problems. These findings can guide targeted parental advice and early preventive strategies to promote healthy sleep in preschool children. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Govindarajan Venguidesvarane, Akila AU - Govindarajan Venguidesvarane A AUID- ORCID: 0000-0002-4387-8564 AD - Department of Community Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, India. FAU - Varadarajan, Samya AU - Varadarajan S AUID- ORCID: 0000-0002-6396-5593 AD - Department of Community Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, India vsamya@gmail.com. FAU - Rajamohan, Muthukumar AU - Rajamohan M AUID- ORCID: 0000-0003-4029-558X AD - Department of Community Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, India. FAU - Krupa, Murugesan AU - Krupa M AUID- ORCID: 0000-0003-0649-5406 AD - Department of Speech Language Pathology, Sri Ramachandra Faculty of Audiology and Speech Language Pathology, Chennai, India. FAU - Ramaswamy, Karthik Narayanan AU - Ramaswamy KN AUID- ORCID: 0009-0006-2440-3682 AD - Department of Pediatric Intensive Care, Rainbow Children's Hospital and BirthRight Guindy, Chennai, India. LA - eng PT - Journal Article DEP - 20251204 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - India/epidemiology MH - Cross-Sectional Studies MH - Child, Preschool MH - Female MH - Male MH - *Screen Time MH - *Sleep Wake Disorders/epidemiology MH - Prevalence MH - ROC Curve MH - Logistic Models MH - Rural Population PMC - PMC12684157 OTO - NOTNLM OT - Child OT - Community child health OT - EPIDEMIOLOGY OT - PAEDIATRICS OT - PUBLIC HEALTH COIS- Competing interests: None declared. EDAT- 2025/12/05 01:01 MHDA- 2025/12/05 01:02 PMCR- 2025/12/04 CRDT- 2025/12/04 20:44 PHST- 2025/12/05 01:02 [medline] PHST- 2025/12/05 01:01 [pubmed] PHST- 2025/12/04 20:44 [entrez] PHST- 2025/12/04 00:00 [pmc-release] AID - bmjopen-2025-109376 [pii] AID - 10.1136/bmjopen-2025-109376 [doi] PST - epublish SO - BMJ Open. 2025 Dec 4;15(12):e109376. doi: 10.1136/bmjopen-2025-109376. PMID- 41344404 OWN - NLM STAT- MEDLINE DCOM- 20260122 LR - 20260129 IS - 2405-4577 (Electronic) IS - 2405-4577 (Linking) VI - 71 DP - 2026 Feb TI - Multiple regression models to predict electrical bioimpedance variables through anthropometric and simple measures in children aged 6-12 years. PG - 102842 LID - S2405-4577(25)03148-1 [pii] LID - 10.1016/j.clnesp.2025.11.162 [doi] AB - BACKGROUND AND AIMS: Obesity is one of the most common nutritional and metabolic disorders worldwide, affecting all age groups. Multiple regression models can be used to predict bioelectrical impedance analysis (BIA) variables in various populations. These models incorporate a set of anthropometric and simple measures to improve the accuracy of predicting BIA variables. The goal was to develop and internally validate multiple regression models to predict BIA variables using simple clinical and anthropometric measurements in children aged 6-12 years. METHODS: This study employs an observational cross-sectional design. Body mass, height, body composition through BIA, anthropometric circumferences, and skinfolds were evaluated. Anthropometric indices were calculated. Statistical analyses were performed using R software. Non-parametric statistical tests were applied after a normality test. Pearson's correlation coefficients were calculated to assess linear associations between each pair of variables. The multiple regression models were adjusted using a stepwise method with the Akaike information criterion. The significance level was p 6). Group differences used Kruskal-Wallis and Mann-Whitney U tests with Bonferroni correction (P<.004). Associations used chi-square tests with Cramer V. Leak-safe machine learning (patient-wise GroupKFold) classified SevereDay (same day) and SevereTomorrow (next day) using actigraphy, sleep, energy, and demographic data. RESULTS: BD without ADHD showed the tightest coupling of extreme activity with negative mood and energy (Cramer V of up to 0.24; P<.004). ADHD without BD showed stronger links between activity and positive energy. Machine learning achieved a receiver operating characteristic area under the curve (ROC-AUC) of 0.85, an accuracy of 0.79, and an F1-score of 0.67 for SevereDay. SevereTomorrow performance was moderate (ROC-AUC=0.80; accuracy=0.79; F1-score=0.60). Energy variability and actigraphy averages/peaks were the top predictors. CONCLUSIONS: Integrating actigraphy, sleep, and daily energy ratings identifies severe mood days and provides early next-day risk signals in hospitalized adolescents. The findings support wearable-based phenotyping for precision monitoring, with external validation needed in outpatients. CI - (c) Rasim S Diler, Farzan Vahedifard, Boris Birmaher, Satish Iyengar, Maria Wolfe, Brianna N Lepore, Mariah Chobany, Halimah Abdul-Waalee, Greeshma Malgireddy, Jonathan A Hart, Michele A Bertocci. Originally published in JMIR Mental Health (https://mental.jmir.org). FAU - Diler, Rasim S AU - Diler RS AUID- ORCID: 0000-0001-5895-6572 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Vahedifard, Farzan AU - Vahedifard F AUID- ORCID: 0000-0002-0803-7831 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Birmaher, Boris AU - Birmaher B AUID- ORCID: 0000-0001-9299-6519 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Iyengar, Satish AU - Iyengar S AUID- ORCID: 0000-0002-9329-6853 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Wolfe, Maria AU - Wolfe M AUID- ORCID: 0009-0009-2385-4379 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Lepore, Brianna N AU - Lepore BN AUID- ORCID: 0009-0000-6541-7948 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Chobany, Mariah AU - Chobany M AUID- ORCID: 0000-0003-3118-8432 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Abdul-Waalee, Halimah AU - Abdul-Waalee H AUID- ORCID: 0009-0005-6560-2816 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Malgireddy, Greeshma AU - Malgireddy G AUID- ORCID: 0000-0002-6641-6733 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Hart, Jonathan A AU - Hart JA AUID- ORCID: 0009-0003-0825-2587 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. FAU - Bertocci, Michele A AU - Bertocci MA AUID- ORCID: 0000-0002-3857-1226 AD - Department of Psychiatry, University of Pittsburgh, 3811 O'Hara Street, Pittsburgh, PA, 15213, United States, 1 3125136325. LA - eng GR - R01 MH121451/MH/NIMH NIH HHS/United States GR - S10 OD028483/OD/NIH HHS/United States PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251204 PL - Canada TA - JMIR Ment Health JT - JMIR mental health JID - 101658926 SB - IM MH - Humans MH - *Bipolar Disorder/diagnosis/physiopathology MH - *Actigraphy MH - *Attention Deficit Disorder with Hyperactivity/diagnosis/physiopathology MH - *Machine Learning MH - Male MH - Female MH - Adolescent MH - Self Report MH - Child MH - *Affect/physiology MH - Diagnosis, Differential MH - Severity of Illness Index PMC - PMC12677876 OTO - NOTNLM OT - ADHD OT - actigraphy OT - adolescents OT - attention-deficit/hyperactivity disorder OT - bipolar disorder OT - energy OT - machine learning OT - mood COIS- Conflicts of Interest: FV, SI, JAH, MAB, and RSD have no financial interests or potential conflicts of interest. BB has or will receive royalties for publications from Random House, Inc (New hope for children and teens with bipolar disorder) and Lippincott Williams & Wilkins (Treating child and adolescent depression). He is employed by the University of Pittsburgh and the University of Pittsburgh Medical Center and receives research funding from the National Institute of Mental Health. The funding sources exerted no influence over the work. EDAT- 2025/12/04 19:37 MHDA- 2025/12/04 19:38 PMCR- 2025/12/04 CRDT- 2025/12/04 16:43 PHST- 2025/05/27 00:00 [received] PHST- 2025/09/12 00:00 [revised] PHST- 2025/09/18 00:00 [accepted] PHST- 2025/12/04 19:38 [medline] PHST- 2025/12/04 19:37 [pubmed] PHST- 2025/12/04 16:43 [entrez] PHST- 2025/12/04 00:00 [pmc-release] AID - v12i1e78163 [pii] AID - 78163 [pii] AID - 10.2196/78163 [doi] PST - epublish SO - JMIR Ment Health. 2025 Dec 4;12:e78163. doi: 10.2196/78163. PMID- 41343581 OWN - NLM STAT- MEDLINE DCOM- 20251204 LR - 20251208 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 12 DP - 2025 TI - Association of non-nutritive sweetener consumption with food craving and body image among university students: A cross-sectional study. PG - e0335838 LID - 10.1371/journal.pone.0335838 [doi] LID - e0335838 AB - Non-nutritive sweeteners (NNS) are widely used for weight control and dietary regulation by university students, however, their psychological associations remain unclear. The aim of this study to investigate the associations between NNS consumption and food craving, and body dissatisfaction. A cross-sectional analysis was conducted among 300 students from Applied Science Private University (ASU) in Amman, Jordan. Participants completed a validated online questionnaire including demographic data, NNS consumption, food craving using Food Craving Questionnaire-Trait Rediced (FCQ-Tr), and perceptions of Sihhouette Ratine Scale Dissatisfcation index (SRS-D) body image using. To evaluate the associations between NNS exposure and psychological outcomes, age, sex, body mass index (BMI), dieting status, smoking behavior, were adjusted using multivariable linear and ordinal regression models. The NNS consumption was 83.3% among university students, with 30.0% indicating daily use of NNS. Increased frequency of NNS intake was significantly associated with higher FCQ-T-r scores (beta = 0.21, 95% CI [0.08-0.34], p = 0.002) and elevated SRS-D scores (beta = 0.17, 95% CI [0.05-0.29], p = 0.006). Also (74.3%) reported no mood change after NNS intake, and 21.0% reported mood enhancement. These findings found that frequent NNS = intake is associated with heightened food craving and body dissatisfaction among students, independent of body weight, age, smoking or academic faculty. CI - Copyright: (c) 2025 AL-Dalaeen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Al-Dalaeen, Anfal AU - Al-Dalaeen A AUID- ORCID: 0000-0002-2685-7294 AD - Department of Clinical Nutrition and Dietetics, Faculty of Allied Medical Sciences, Applied Science Private University, Amman, Jordan. FAU - Hamid, Hebah AU - Hamid H AD - Department of Clinical Nutrition and Dietetics, Faculty of Allied Medical Sciences, Applied Science Private University, Amman, Jordan. FAU - Hasan, Tasneem Abu AU - Hasan TA AD - Department of Clinical Nutrition and Dietetics, Faculty of Allied Medical Sciences, Applied Science Private University, Amman, Jordan. LA - eng PT - Journal Article DEP - 20251204 PL - United States TA - PLoS One JT - PloS one JID - 101285081 RN - 0 (Non-Nutritive Sweeteners) SB - IM MH - Humans MH - Male MH - Female MH - Cross-Sectional Studies MH - *Students/psychology MH - *Craving MH - *Body Image/psychology MH - Universities MH - Young Adult MH - Adult MH - *Non-Nutritive Sweeteners/administration & dosage MH - Surveys and Questionnaires MH - Adolescent MH - *Feeding Behavior/psychology MH - Jordan MH - Body Mass Index PMC - PMC12677766 COIS- The authors have declared that no competing interests exist. EDAT- 2025/12/04 19:37 MHDA- 2025/12/04 19:38 PMCR- 2025/12/04 CRDT- 2025/12/04 14:03 PHST- 2025/08/20 00:00 [received] PHST- 2025/10/15 00:00 [accepted] PHST- 2025/12/04 19:38 [medline] PHST- 2025/12/04 19:37 [pubmed] PHST- 2025/12/04 14:03 [entrez] PHST- 2025/12/04 00:00 [pmc-release] AID - PONE-D-25-42757 [pii] AID - 10.1371/journal.pone.0335838 [doi] PST - epublish SO - PLoS One. 2025 Dec 4;20(12):e0335838. doi: 10.1371/journal.pone.0335838. eCollection 2025. PMID- 41343399 OWN - NLM STAT- MEDLINE DCOM- 20260323 LR - 20260323 IS - 1939-134X (Electronic) IS - 1040-3590 (Linking) VI - 38 IP - 4 DP - 2026 Apr TI - The development and psychometric validation of the Food and Alcohol Disturbance Expectancy Questionnaire (FAD-EQ) in three independent college student samples. PG - 307-318 LID - 10.1037/pas0001438 [doi] AB - Food and alcohol disturbance (FAD; i.e., use of compensatory behaviors to offset alcohol-related calories and/or to enhance the effects of alcohol) is prevalent among college students and associated with negative consequences. Expectancy effects may play a critical role in understanding the phenomenology and trajectory of FAD, as research from the alcohol and disordered eating literature suggest expectancies are uniquely linked to engagement in these behaviors and their related outcomes. However, little is known about FAD-specific expectancies. This study aimed to develop and psychometrically validate the FAD Expectancy Questionnaire (FAD-EQ). Using three independent multisite samples of U.S. college students (Sample 1: n = 2,594; Sample 2: n = 1,693; Sample 3: n = 3,824), we conducted exploratory and confirmatory factor analyses, tested measurement invariance across sex assigned at birth, evaluated the measure's construct validity, and examined whether FAD expectancy profiles differed by type of past-month FAD engagement. Results supported a two-factor structure (positive and negative FAD expectancies) for the 30-item FAD-EQ, which demonstrated acceptable internal consistency, measurement invariance across sex assigned at birth, and preliminary evidence of convergent and discriminant validity. Similar to results from the alcohol expectancy literature, students engaging in FAD for alcohol enhancement and caloric compensation purposes endorsed the strongest positive and weakest negative expectancies, while students who denied past-month FAD endorsed the weakest positive and strongest negative expectancies. Findings from this study offer a robust tool for assessing FAD expectancies and provide several avenues for future research, intervention, and prevention efforts. (PsycInfo Database Record (c) 2026 APA, all rights reserved). FAU - Berry, Katherine A AU - Berry KA AUID- ORCID: 0000-0002-2632-7437 AD - Department of Psychology, University of Wyoming. FAU - De Young, Kyle P AU - De Young KP AD - Department of Psychology, University of Wyoming. FAU - Looby, Alison AU - Looby A AD - Department of Psychology, University of Wyoming. CN - Stimulant Norms and Prevalence 2 (SNAP2) Study Team LA - eng PT - Journal Article PT - Validation Study DEP - 20251204 PL - United States TA - Psychol Assess JT - Psychological assessment JID - 8915253 SB - IM MH - Humans MH - Female MH - Male MH - Psychometrics MH - *Students/psychology MH - Young Adult MH - Universities MH - Reproducibility of Results MH - Surveys and Questionnaires/standards MH - Adolescent MH - Adult MH - United States MH - *Alcohol Drinking in College/psychology MH - *Feeding and Eating Disorders/psychology MH - Factor Analysis, Statistical MH - *Feeding Behavior/psychology MH - *Alcohol Drinking/psychology EDAT- 2025/12/04 19:37 MHDA- 2026/03/23 13:03 CRDT- 2025/12/04 13:25 PHST- 2026/03/23 13:03 [medline] PHST- 2025/12/04 19:37 [pubmed] PHST- 2025/12/04 13:25 [entrez] AID - 2026-96056-001 [pii] AID - 10.1037/pas0001438 [doi] PST - ppublish SO - Psychol Assess. 2026 Apr;38(4):307-318. doi: 10.1037/pas0001438. Epub 2025 Dec 4. PMID- 41343193 OWN - NLM STAT- MEDLINE DCOM- 20251204 LR - 20251206 IS - 2047-2986 (Electronic) IS - 2047-2978 (Print) IS - 2047-2978 (Linking) VI - 15 DP - 2025 Dec 5 TI - Establishment and validation of a prediction model for small vulnerable newborns: a retrospective study. PG - 04337 LID - 10.7189/jogh.15.04337 [doi] LID - 04337 AB - BACKGROUND: The concept of small vulnerable newborns has been proposed, including preterm birth, low birth weight, and small for gestational age, leading causes of perinatal mortality. We aimed to identify high-risk factors for small vulnerable newborns and develop a predictive model through a retrospective analysis. METHODS: We collected clinical data from pregnant women who met inclusion criteria between January 2015 and December 2023 and divided them into training and validation cohorts. We used univariate analysis and mean decreases in the Gini index to screen for potential risk factors. We applied the least absolute shrinkage and selection operator regression to select final predictors and construct a nomogram. We assessed model performance using receiver operating characteristic curves, calibration curves, and clinical decision analysis, with internal validation via 10-fold cross-validation and temporal internal validation. RESULTS: Among 129 554 women, 13 801 (10.66%) had small vulnerable newborn, with the incidence increasing from 2015 (10.15%) to 2023 (11.61%). Key risk factors included multiple pregnancies (odds ratio (OR) = 37.2), pre-pregnancy body mass index (BMI) of <18.5 (OR = 8.61) and >/=25 kg/m(2) (OR = 6.40), maternal age of <25 (OR = 6.81) and >/=35 years (OR = 3.72), hypertensive disorders of pregnancy (OR = 2.81), and placental disorders (OR = 3.03). Other significant factors were assisted reproductive technology, mycoplasma/chlamydia infection, and elevated bile acids. The nomogram demonstrated strong predictive performance (area under the curve = 0.873). CONCLUSIONS: The incidence of small, vulnerable newborns rose notably during 2021-2023. The developed model, incorporating age, pre-pregnancy BMI, multiple pregnancies, hypertensive disorders of pregnancy, and placental disorders, is designed to be applied in the third trimester and enables risk identification, facilitating targeted interventions to reduce neonatal mortality and complications. REGISTRATION: Chinese Clinical Trial Registry, ChiCTR2400093923. CI - Copyright (c) 2025 by the Journal of Global Health. All rights reserved. FAU - Xiao, Chengqi AU - Xiao C AD - The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Xu, Chuangchuang AU - Xu C AD - The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. FAU - Zhang, Lijun AU - Zhang L AD - The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. FAU - Lai, Dongmei AU - Lai D AD - The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. AD - Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20251205 PL - Scotland TA - J Glob Health JT - Journal of global health JID - 101578780 SB - IM MH - Humans MH - Retrospective Studies MH - Female MH - Infant, Newborn MH - Pregnancy MH - Adult MH - *Infant, Small for Gestational Age MH - Risk Factors MH - Infant, Low Birth Weight MH - Nomograms MH - Risk Assessment PMC - PMC12677243 COIS- Disclosure of interest: The authors completed the ICMJE Disclosure of Interest Form (available upon request from the corresponding author) and disclose no relevant interests. EDAT- 2025/12/04 13:39 MHDA- 2025/12/04 13:40 PMCR- 2025/12/05 CRDT- 2025/12/04 11:34 PHST- 2025/12/04 13:40 [medline] PHST- 2025/12/04 13:39 [pubmed] PHST- 2025/12/04 11:34 [entrez] PHST- 2025/12/05 00:00 [pmc-release] AID - jogh-15-04337 [pii] AID - 10.7189/jogh.15.04337 [doi] PST - epublish SO - J Glob Health. 2025 Dec 5;15:04337. doi: 10.7189/jogh.15.04337. PMID- 41342923 OWN - NLM STAT- MEDLINE DCOM- 20260529 LR - 20260813 IS - 1618-2650 (Electronic) IS - 1618-2642 (Print) IS - 1618-2642 (Linking) VI - 418 IP - 12 DP - 2026 Jun TI - Development and validation of an LC-MS/MS method for simultaneous determination of 39 PFAS in soil samples: applications to playgrounds in Attica, Greece. PG - 3537-3553 LID - 10.1007/s00216-025-06251-x [doi] AB - Per- and polyfluoroalkyl substances (PFAS) are regarded as persistent environmental pollutants with the potential to exert deleterious effects on human health, particularly in children, who are highly susceptible to the effects of environmental exposures. This study presents the development and validation of a sensitive LC-MS/MS method for the simultaneous analysis of 39 PFAS compounds in soil samples. Method performance characteristics that were examined through a fully validated protocol including linearity, precision, detectability, and trueness proved its fitness for environmental monitoring. This method was subsequently employed in an analysis of 67 soil samples obtained from playgrounds in Attica, Greece. The results indicated the presence of PFAS in all of the samples analyzed, with PFPeA, PFOA, PFDA, PFBS, and PFOS being the most prevalent compounds in terms of concentration levels. Risk assessment of PFAS occurrence in these samples showed that the risk quotient for PFOS exceeded 1 in 20% of the studied samples, indicating a potential risk of exposure for children. Concentrations varied depending on urban activities and potential pollution sources. This study provides a reliable tool for the systematic monitoring of PFAS in soil and emphasizes the importance of ongoing monitoring and risk assessment in areas where children play. CI - (c) 2025. The Author(s). FAU - Gerokonstantis, Dimitrios-Triantafyllos AU - Gerokonstantis DT AD - Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, Athens, Greece. FAU - Koupa, Anastasia AU - Koupa A AD - Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, Athens, Greece. FAU - Bouzoukas, Christoforos AU - Bouzoukas C AD - Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, Athens, Greece. FAU - Vysaniaris, Ioannis-Chrysovalantis AU - Vysaniaris IC AD - Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, Athens, Greece. FAU - Kostakis, Marios G AU - Kostakis MG AD - Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, Athens, Greece. FAU - Thomaidis, Nikolaos S AU - Thomaidis NS AUID- ORCID: 0000-0002-4624-4735 AD - Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Panepistimioupolis Zografou, Athens, Greece. ntho@chem.uoa.gr. LA - eng PT - Journal Article PT - Validation Study DEP - 20251204 PL - Germany TA - Anal Bioanal Chem JT - Analytical and bioanalytical chemistry JID - 101134327 RN - 0 (Fluorocarbons) RN - 0 (Soil) RN - 0 (Soil Pollutants) SB - IM MH - Humans MH - Environmental Monitoring/methods MH - *Fluorocarbons/analysis MH - Greece MH - *Liquid Chromatography-Mass Spectrometry/methods MH - *Parks, Recreational/statistics & numerical data MH - Reproducibility of Results MH - Soil/chemistry MH - *Soil Pollutants/analysis MH - *Tandem Mass Spectrometry/methods PMC - PMC13221360 OTO - NOTNLM OT - Analytical validation OT - PFAS OT - Playground OT - Risk assessment OT - Soils COIS- Declarations. Ethics approval: This article does not contain any studies with animals performed by any of the authors. Source of biological material: Biological material is not included in this study. Statement on animal welfare: This article does not contain any studies with animals performed by any of the authors. Conflict of interest: The authors declare no competing interests. EDAT- 2025/12/04 13:38 MHDA- 2026/05/29 15:41 PMCR- 2025/12/04 CRDT- 2025/12/04 11:13 PHST- 2025/09/03 00:00 [received] PHST- 2025/11/13 00:00 [accepted] PHST- 2025/11/05 00:00 [revised] PHST- 2026/05/29 15:41 [medline] PHST- 2025/12/04 13:38 [pubmed] PHST- 2025/12/04 11:13 [entrez] PHST- 2025/12/04 00:00 [pmc-release] AID - 10.1007/s00216-025-06251-x [pii] AID - 6251 [pii] AID - 10.1007/s00216-025-06251-x [doi] PST - ppublish SO - Anal Bioanal Chem. 2026 Jun;418(12):3537-3553. doi: 10.1007/s00216-025-06251-x. Epub 2025 Dec 4. PMID- 41342002 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251204 LR - 20260307 IS - 2950-1334 (Electronic) IS - 2950-1334 (Linking) VI - 11 DP - 2026 Feb TI - Design and rationale of the MIGHTEE study: Motivational interviewing and group heart transplant exercise and education. PG - 100421 LID - 10.1016/j.jhlto.2025.100421 [doi] LID - 100421 AB - BACKGROUND: Many pediatric heart transplant (HT) recipients have decreased physical activity, which worsens their cardiovascular risk profile, contributes to long-term morbidity and mortality, and is associated with lower quality of life (QOL). While participation in a regular exercise program improves the cardiovascular health of pediatric HT recipients, there are limited data on how to best implement exercise-based interventions that are accessible, effective, and sustainable. METHODS: This manuscript describes the design, rationale, and baseline cohort characteristics of the Motivational Interviewing and Group Heart Transplant Exercise and Education (MIGHTEE) intervention, a structured virtual group exercise program developed with input from pediatric HT recipients and their families. RESULTS: Over 24 months, 65 HT recipients were screened, and 44 recipients were determined to be eligible. Of the 23 subjects enrolled in MIGHTEE (52% enrollment rate), the majority were male (52%), and 26% self-identified as Black. The mean subject age was 16.1 years (standard deviation [SD] = 2.2), and the mean time from HT was 4.9 years (range = 1-18 years) with 43% having a history of congenital heart disease. All participants completed baseline testing, and wearable device adherence exceeded 80% of monitored days. CONCLUSIONS: This manuscript describes the rationale and study design of the MIGHTEE study, which will provide important data regarding the optimal methods for delivering physical activity-related interventions to pediatric HT survivors. This design and rationale paper highlights the feasibility of enrollment and program delivery, with outcomes analyses forthcoming in subsequent reports. CI - (c) 2025 International Society for Heart and Lung Transplantation. FAU - Edelson, Jonathan B AU - Edelson JB AD - Division of Cardiology, The Children's Hospital of Philadelphia and Department of Pediatrics Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA. FAU - Schneider, Lauren AU - Schneider L AD - Lucille Packard Children's Hospital at Stanford, Palo Alto, CA. FAU - O'Malley, Shannon AU - O'Malley S AD - Division of Cardiology, The Children's Hospital of Philadelphia and Department of Pediatrics Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA. FAU - Somogie, Jessica AU - Somogie J AD - Lucille Packard Children's Hospital at Stanford, Palo Alto, CA. FAU - Huang, Jing AU - Huang J AD - Division of General Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA. FAU - Li, Zeyu Nancy AU - Li ZN AD - Division of General Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA. FAU - Boyle, Carley AU - Boyle C AD - Division of Cardiology, The Children's Hospital of Philadelphia and Department of Pediatrics Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA. FAU - O'Connor, Matthew J AU - O'Connor MJ AD - Division of Cardiology, The Children's Hospital of Philadelphia and Department of Pediatrics Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA. FAU - Paridon, Stephen AU - Paridon S AD - Division of Cardiology, The Children's Hospital of Philadelphia and Department of Pediatrics Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA. FAU - Lin, Kimberly Y AU - Lin KY AD - Division of Cardiology, The Children's Hospital of Philadelphia and Department of Pediatrics Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA. FAU - Rossano, Joseph W AU - Rossano JW AD - Division of Cardiology, The Children's Hospital of Philadelphia and Department of Pediatrics Perelman School of Medicine at The University of Pennsylvania, Philadelphia, PA. FAU - Lane-Fall, Meghan AU - Lane-Fall M AD - Department of Anesthesiology and Critical Care Medicine and Penn Center for Perioperative Research and Transformation, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA. FAU - Cousino, Melissa K AU - Cousino MK AD - University of Michigan Congenital Heart Center, C.S. Mott Children's Hospital, Ann Arbor, MI. LA - eng GR - K23 HL169833/HL/NHLBI NIH HHS/United States PT - Journal Article DEP - 20251101 PL - United States TA - JHLT Open JT - JHLT open JID - 9918716187806676 PMC - PMC12671351 OTO - NOTNLM OT - Exercise OT - Heart transplant OT - Intervention OT - Methods OT - Pediatric OT - Physical activity OT - Quality of life EDAT- 2025/12/04 06:27 MHDA- 2025/12/04 06:28 PMCR- 2025/11/01 CRDT- 2025/12/04 05:00 PHST- 2025/12/04 06:28 [medline] PHST- 2025/12/04 06:27 [pubmed] PHST- 2025/12/04 05:00 [entrez] PHST- 2025/11/01 00:00 [pmc-release] AID - S2950-1334(25)00216-2 [pii] AID - 100421 [pii] AID - 10.1016/j.jhlto.2025.100421 [doi] PST - epublish SO - JHLT Open. 2025 Nov 1;11:100421. doi: 10.1016/j.jhlto.2025.100421. eCollection 2026 Feb. PMID- 41341679 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251204 LR - 20251206 IS - 2233-8276 (Print) IS - 2233-8268 (Electronic) IS - 2233-8276 (Linking) VI - 15 IP - 4 DP - 2025 Dec TI - Examining the diagnostic validity of the ISAAC asthma questionnaire among participants from Singapore and Malaysia. PG - 294-299 LID - 10.5415/apallergy.0000000000000234 [doi] AB - BACKGROUND: Asthma is a chronic respiratory condition affecting 3,340 cases per 100,000 individuals globally. The significant global health burden of asthma necessitates the development and use of valid diagnostic tools for epidemiological purposes. OBJECTIVE: This study evaluated the diagnostic accuracy of the International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire among participants from the Singapore/Malaysia Cross-sequential Genetic Epidemiology Study (SMCGES). METHODS: Investigators administered the ISAAC survey questionnaire to SMCGES participants. Symptoms related to asthma were compared against diagnosed asthma, which was characterized by a questionnaire-reported history of asthma and exhibiting a positive skin prick reaction to allergen extracts from 2 dust mite species. Diagnostic accuracy was assessed via sensitivity (Se), specificity (Sp), positive and negative predictive values, and Youden's Index (J). RESULTS: This study analyzed data from 4,028 participants from Malaysia and 11,473 participants from Singapore. Asthma symptom prevalence differed between Malaysia and Singapore, with ever wheeze being the most prevalent in both populations. Diagnosed asthma was more prevalent in Singapore (17.3%, 95% confidence interval [CI]: 16.6-18.1%) than in Malaysia (9.7%, 95% CI: 8.8-10.7%). Ever wheeze showed the best diagnostic performance for diagnosed asthma in Malaysia (Se = 0.548, Sp = 0.831, J = 0.379) and Singapore (Se = 0.679, Sp = 0.888, J = 0.566). Combining symptoms or asthma medication usage improved accuracy slightly, with the most valid combinations being ever wheeze or exercise-induced wheeze in Malaysia (Se = 0.557, Sp = 0.824, J = 0.381) and usage of bronchodilators, beta-agonists, inhaled steroids, or leukotriene modifiers in Singapore (Se = 0.771, Sp = 0.871, J = 0.642). CONCLUSION: The modified ISAAC questionnaire used by the SMCGES showed good Se and Sp for diagnosed asthma, especially when combining various symptom indicators or usages of different asthma medications. These findings substantiate the continued use of the ISAAC questionnaire as a valuable survey tool in epidemiological studies across diverse populations. CI - Copyright (c) 2025. Asia Pacific Association of Allergy, Asthma and Clinical Immunology. FAU - Wong, Qi Yi Ambrose AU - Wong QYA AUID- ORCID: 0009-0000-5205-4033 AD - Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore. FAU - Cen, Dingyu AU - Cen D AUID- ORCID: 0009-0004-9608-564X AD - Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore. FAU - Lim, Jun Jie AU - Lim JJ AUID- ORCID: 0000-0001-5485-1749 AD - Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore. FAU - Wong, Jia Yi Karen AU - Wong JYK AUID- ORCID: 0009-0006-2800-4451 AD - Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore. FAU - Nadeem, Kashaf AU - Nadeem K AD - Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Petaling Jaya, Malaysia. FAU - Yap, Zheng Yang Ervin AU - Yap ZYE AD - Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Petaling Jaya, Malaysia. FAU - Ng, Jun Yan AU - Ng JY AUID- ORCID: 0000-0003-2548-397X AD - Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore. FAU - Lim, Yi Ying Eliza AU - Lim YYE AUID- ORCID: 0000-0002-7116-8172 AD - Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore. FAU - Sio, Yang Yie AU - Sio YY AUID- ORCID: 0000-0002-3549-1706 AD - Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore. FAU - Say, Yee How AU - Say YH AUID- ORCID: 0000-0003-2363-5239 AD - Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Petaling Jaya, Malaysia. FAU - Reginald, Kavita AU - Reginald K AUID- ORCID: 0000-0003-1530-5934 AD - Department of Biological Sciences, School of Medical and Life Sciences, Sunway University, Petaling Jaya, Malaysia. FAU - Chew, Fook Tim AU - Chew FT AUID- ORCID: 0000-0003-1337-5146 AD - Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore. LA - eng PT - Journal Article DEP - 20251202 PL - Netherlands TA - Asia Pac Allergy JT - Asia Pacific allergy JID - 101561954 PMC - PMC12672177 OTO - NOTNLM OT - Allergy OT - asthma OT - point prevalence OT - questionnaire OT - sensitivity OT - specificity COIS- FTC reports grants from the National University of Singapore, Singapore Ministry of Education Academic Research Fund, Singapore Immunology Network, Singapore National Medical Research Council, Singapore Biomedical Research Council, Singapore National Research Foundation, Singapore Food Agency, Singapore Economic Development Board, and the Singapore Agency for Science Technology and Research. These grants were in effect during this study. FTC also reports receiving consulting fees from Sime Darby Technology Centre, First Resources Ltd, Genting Plantation, Olam International, Musim Mas, and Syngenta Crop Protection. The remaining authors declare no conflicts of interest. EDAT- 2025/12/04 06:26 MHDA- 2025/12/04 06:27 PMCR- 2025/12/02 CRDT- 2025/12/04 04:56 PHST- 2025/07/09 00:00 [received] PHST- 2025/09/13 00:00 [accepted] PHST- 2025/12/04 06:27 [medline] PHST- 2025/12/04 06:26 [pubmed] PHST- 2025/12/04 04:56 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - APA-25-053 [pii] AID - 10.5415/apallergy.0000000000000234 [doi] PST - ppublish SO - Asia Pac Allergy. 2025 Dec;15(4):294-299. doi: 10.5415/apallergy.0000000000000234. Epub 2025 Dec 2. PMID- 41341519 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251204 LR - 20251206 IS - 2164-2850 (Electronic) IS - 2164-2850 (Linking) VI - 13 IP - 1 DP - 2025 TI - Adolescent sleep and food cravings: randomized controlled trial of a sleep intervention. PG - 2590853 LID - 10.1080/21642850.2025.2590853 [doi] LID - 2590853 AB - BACKGROUND: This randomized pilot study examined the relationships between objectively measured sleep characteristics and food cravings in adolescents and examined whether a brief sleep intervention would reduce food cravings from baseline to post-intervention compared to an active control group. METHODS: A community sample of 51 adolescents aged 13-17 years old were randomized to complete a cognitive behavioral therapy (CBT) sleep intervention or a study skills control intervention. The sleep intervention involved one telehealth CBT session, while the control group completed one telehealth CBT session to improve study skills. Sleep was assessed using actigraphs and adolescents reported on food cravings using a validated questionnaire at baseline and post-intervention. RESULTS: Sleep fragmentation, but not sleep duration, was a significant predictor of food cravings at baseline, controlling for age, beta = 0.35, t = 2.41, p = 0.02, 95% CI [0.01-0.11]. The sleep intervention significantly reduced food cravings from baseline to post-intervention compared to the control group (significant time x intervention interaction, F(1, 45) = 4.30, p = 0.044, partial eta(2) = 0.09, medium effect). CONCLUSIONS: The results of this study support the relationship between poor sleep quality and more frequent food cravings, as well as the preliminary efficacy of a brief, CBT-based sleep intervention in reducing food cravings. The brief and digital delivery of this intervention enhances its accessibility. CI - (c) 2025 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. FAU - Kidwell, Katherine M AU - Kidwell KM AD - Department of Psychology, Syracuse University, Marley Education Center, Syracuse, NY, USA. FAU - Hamilton, Antonia L AU - Hamilton AL AD - Department of Psychology, Syracuse University, Marley Education Center, Syracuse, NY, USA. FAU - Deyo, Alexa G AU - Deyo AG AD - Department of Psychology, Syracuse University, Marley Education Center, Syracuse, NY, USA. FAU - Milligan, Megan A AU - Milligan MA AD - Department of Psychology, Syracuse University, Marley Education Center, Syracuse, NY, USA. FAU - Vrabec, Alison AU - Vrabec A AD - Department of Psychology, Syracuse University, Marley Education Center, Syracuse, NY, USA. FAU - Tully, Lyric K AU - Tully LK AD - Department of Psychology, Syracuse University, Marley Education Center, Syracuse, NY, USA. FAU - Yuhas, Maryam AU - Yuhas M AD - Department of Nutrition and Food Studies, Syracuse University, Syracuse, NY, USA. LA - eng PT - Journal Article DEP - 20251130 PL - England TA - Health Psychol Behav Med JT - Health psychology and behavioral medicine JID - 101624393 PMC - PMC12671425 OTO - NOTNLM OT - Sleep treatment OT - actigraph OT - diet OT - single session OT - sleep intervention COIS- No potential conflict of interest was reported by the author(s). EDAT- 2025/12/04 06:27 MHDA- 2025/12/04 06:28 PMCR- 2025/11/30 CRDT- 2025/12/04 04:54 PHST- 2025/12/04 06:28 [medline] PHST- 2025/12/04 06:27 [pubmed] PHST- 2025/12/04 04:54 [entrez] PHST- 2025/11/30 00:00 [pmc-release] AID - 2590853 [pii] AID - 10.1080/21642850.2025.2590853 [doi] PST - epublish SO - Health Psychol Behav Med. 2025 Nov 30;13(1):2590853. doi: 10.1080/21642850.2025.2590853. eCollection 2025. PMID- 41341447 OWN - NLM STAT- MEDLINE DCOM- 20251204 LR - 20251206 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - From habits to harm: the effects of lifestyle, sleep, and fitness on injury risk in students using a structural equation modeling approach. PG - 1664822 LID - 10.3389/fpubh.2025.1664822 [doi] LID - 1664822 AB - BACKGROUND: University students often deal with a mix of challenges - from frequent sports and recreational injuries to habits like smoking, drinking alcohol, or consuming energy drinks, along with irregular sleep and different levels of physical activity. This study examines the links between lifestyle habits, sports participation, sleep quality, self-perceived fitness, and the likelihood of getting injured. METHODS: In a cross-sectional survey of 933 first-year students (mean age 20.1 +/- 2.5), participants reported lifestyle indicators (cigarettes, alcoholic drinks, energy drinks), sports activity (training volume, athlete/competitive status, sport diversity), sleep quality, self-rated fitness, and the number of injuries causing class absence. Partial least squares structural equation modeling evaluated the measurement properties and the structural paths. RESULTS: Sports activity had a strong, positive association with perceived physical fitness. The interaction of lifestyle and sports activity is negatively associated with fitness, indicating that unhealthy habits attenuate sport-related fitness gains. Lifestyle was negatively associated with sleep quality, while better sleep quality positively predicted fitness. Physical fitness did not show a significant direct association with injury counts. Poorer sleep quality was associated with a higher number of injuries. CONCLUSION: In this large student sample, sleep quality emerged as a pivotal, modifiable protector-linked positively to fitness and negatively to injury risk-whereas sports participation improved fitness, but its benefits were undermined by unhealthy lifestyle behaviours. Injury prevention efforts in student populations should therefore combine promotion of healthy lifestyle choices, sleep hygiene interventions, and safe sport practices. CI - Copyright (c) 2025 Kasovic, Skrinjaric, Vespalec, Mojzis and Knjaz. FAU - Kasovic, Mario AU - Kasovic M AD - Department of General and Applied Kinesiology, Faculty of Kinesiology, University of Zagreb, Zagreb, Croatia. AD - Department of Physical Activities and Health Sciences, Faculty of Sports Studies, Masaryk University, Brno, Czechia. FAU - Skrinjaric, Bruno AU - Skrinjaric B AD - Institute of Economics Zagreb, Zagreb, Croatia. FAU - Vespalec, Tomas AU - Vespalec T AD - Department of Physical Activities and Health Sciences, Faculty of Sports Studies, Masaryk University, Brno, Czechia. FAU - Mojzis, Milan AU - Mojzis M AD - Department of Physical Activities and Health Sciences, Faculty of Sports Studies, Masaryk University, Brno, Czechia. FAU - Knjaz, Damir AU - Knjaz D AD - Department of Kinesiology of Sports, Faculty of Kinesiology, University of Zagreb, Zagreb, Croatia. LA - eng PT - Journal Article DEP - 20251118 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Male MH - Female MH - *Students/statistics & numerical data/psychology MH - Cross-Sectional Studies MH - *Life Style MH - Young Adult MH - *Physical Fitness/physiology MH - Latent Class Analysis MH - Universities MH - Adolescent MH - *Sleep MH - Surveys and Questionnaires MH - Exercise MH - *Sleep Quality MH - Sports/statistics & numerical data MH - Adult MH - *Wounds and Injuries/epidemiology MH - Habits PMC - PMC12669233 OTO - NOTNLM OT - injury occurrence OT - lifestyle habits OT - physical fitness OT - sleep quality OT - sports activity COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/04 06:27 MHDA- 2025/12/04 06:28 PMCR- 2025/11/18 CRDT- 2025/12/04 04:53 PHST- 2025/07/14 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2025/12/04 06:28 [medline] PHST- 2025/12/04 06:27 [pubmed] PHST- 2025/12/04 04:53 [entrez] PHST- 2025/11/18 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1664822 [doi] PST - epublish SO - Front Public Health. 2025 Nov 18;13:1664822. doi: 10.3389/fpubh.2025.1664822. eCollection 2025. PMID- 41341265 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260212 LR - 20260212 IS - 1662-4548 (Print) IS - 1662-453X (Electronic) IS - 1662-453X (Linking) VI - 19 DP - 2025 TI - Gut microbiota signatures in tuberous sclerosis complex and epilepsy: a pilot study. PG - 1655456 LID - 10.3389/fnins.2025.1655456 [doi] LID - 1655456 AB - OBJECTIVE: Tuberous sclerosis complex (TSC) presents with a broad clinical spectrum. While some individuals exhibit mild symptoms, most experience seizures and neuropsychiatric comorbidities. Emerging evidence suggests that both genetic and environmental factors, including gut microbiota, may influence epilepsy susceptibility. The microbiota-gut-brain axis (MGBA) is a key communication pathway through which intestinal microbes impact the central nervous system. Although the role of the MGBA in the pathogenesis of neurological diseases, particularly seizures, has been explored in both animal models and humans, data specific to TSC are lacking. METHODS: In this exploratory study, we assessed whether individuals with TSC (n = 15) display a distinct gut microbial signature using V3-V4 16S rRNA sequencing. Their profiles were compared with two control groups: 18 children with epilepsy (EPI) and 12 age- and sex-matched healthy controls (HC). Stool short-chain fatty acid (SCFA) levels and dietary intake were also evaluated. RESULTS: No significant differences were observed among the three groups in dietary intake, SCFA and branched-chain fatty acid (BCFA) levels, or alpha-diversity. Beta-diversity analysis showed a non-significant trend toward clustering of TSC and EPI samples, indicating a shared microbial profile distinct from HC. Taxonomic analysis revealed a reduction in Firmicutes-particularly the Ruminococcaceae family and the genus Gemmiger-in both TSC and EPI groups, consistent with epilepsy-associated dysbiosis. Notably, the TSC group showed a specific enrichment in Akkermansiaceae, a feature also reported in other neurodevelopmental disorders such as CDKL5 deficiency disorder and cerebral palsy. SIGNIFICANCE: These preliminary findings suggest that gut microbiota alterations may contribute to neuroinflammatory processes linked to epileptogenesis and comorbidities in TSC. Further studies are needed to validate these results and explore microbiota-based therapeutic strategies aimed at improving outcomes and quality of life for individuals with TSC and their caregivers. CI - Copyright (c) 2025 Ottaviano, Marsiglia, Ceccarani, Ancona, Triva, La Briola, Bergamoni, Teutonico, Pompili, Vigano, Ricci, Vignoli and Borghi. FAU - Ottaviano, Emerenziana AU - Ottaviano E AD - Department of Health Sciences, Universita Degli Studi di Milano, Milan, Italy. FAU - Marsiglia, Matteo Domenico AU - Marsiglia MD AD - Department of Health Sciences, Universita Degli Studi di Milano, Milan, Italy. FAU - Ceccarani, Camilla AU - Ceccarani C AD - Institute of Biomedical Technologies, National Research Council, Milan, Italy. FAU - Ancona, Silvia AU - Ancona S AD - Department of Health Sciences, Universita Degli Studi di Milano, Milan, Italy. FAU - Triva, Francesca AU - Triva F AD - Department of Health Sciences, Universita Degli Studi di Milano, Milan, Italy. FAU - La Briola, Francesca AU - La Briola F AD - Child Neurology and Epilepsy Centre, ASST Santi Paolo e Carlo, Milan, Italy. FAU - Bergamoni, Stefania AU - Bergamoni S AD - Childhood and Adolescence Neurology and Psychiatry Unit, ASST GOM Niguarda, Milan, Italy. FAU - Teutonico, Federica AU - Teutonico F AD - Childhood and Adolescence Neurology and Psychiatry Unit, ASST GOM Niguarda, Milan, Italy. FAU - Pompili, Alice AU - Pompili A AD - Universita Degli Studi di Milano, Milan, Italy. FAU - Vigano, Ilaria AU - Vigano I AD - Child Neurology and Epilepsy Centre, ASST Santi Paolo e Carlo, Milan, Italy. FAU - Ricci, Emilia AU - Ricci E AD - Child Neurology and Epilepsy Centre, ASST Santi Paolo e Carlo, Milan, Italy. FAU - Vignoli, Aglaia AU - Vignoli A AD - Department of Health Sciences, Universita Degli Studi di Milano, Milan, Italy. AD - Childhood and Adolescence Neurology and Psychiatry Unit, ASST GOM Niguarda, Milan, Italy. FAU - Borghi, Elisa AU - Borghi E AD - Department of Health Sciences, Universita Degli Studi di Milano, Milan, Italy. LA - eng PT - Journal Article DEP - 20251118 PL - Switzerland TA - Front Neurosci JT - Frontiers in neuroscience JID - 101478481 EIN - Front Neurosci. 2026 Jan 16;19:1760688. doi: 10.3389/fnins.2025.1760688. PMID: 41624140 PMC - PMC12670250 OTO - NOTNLM OT - children OT - epilepsy OT - gut microbiota brain axis OT - inflammation OT - tuberous sclerosis complex COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The reviewer GdO declared a past co-authorship / collaboration with the author AV. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. EDAT- 2025/12/04 06:26 MHDA- 2025/12/04 06:27 PMCR- 2025/11/18 CRDT- 2025/12/04 04:51 PHST- 2025/06/27 00:00 [received] PHST- 2025/11/03 00:00 [accepted] PHST- 2025/12/04 06:26 [pubmed] PHST- 2025/12/04 06:27 [medline] PHST- 2025/12/04 04:51 [entrez] PHST- 2025/11/18 00:00 [pmc-release] AID - 10.3389/fnins.2025.1655456 [doi] PST - epublish SO - Front Neurosci. 2025 Nov 18;19:1655456. doi: 10.3389/fnins.2025.1655456. eCollection 2025. PMID- 41340664 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251204 LR - 20251206 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Development and Validation of an Indian Nutrition and Food Literacy Tool (INFOLIT) for adolescents. PG - 1626673 LID - 10.3389/fnut.2025.1626673 [doi] LID - 1626673 AB - BACKGROUND: Nutrition and food literacy (NFL) are interconnected yet distinct concepts concerning the capability to comprehend and utilize knowledge pertaining to nutrition and food. NFL is a significant driver that shapes an individuals' diet. This is more so among adolescents whose dietary choices leave a lasting impact on nutritional and health outcomes in adulthood. Assessing NFL can help design tailored interventions to empower adolescents to make informed dietary decision. However, there is lack of standardized tools to assess NFL among adolescents, especially in India. OBJECTIVE: To develop and validate an Indian Nutrition and Food Literacy Tool (INFOLIT) for adolescents with a focus on key literacy domains. MATERIALS AND METHODS: This five-phased cross-sectional sequential exploratory study was conducted among adolescents (13-15y) in Hyderabad, Telangana. In Phase-1, an item-pool was created for tool development through literature review and it was tested for content validity in phase-2 by experts (n = 5) using a Content Validity Index (CVI) and Cognitive Interviews (CIs) with adolescents (n = 15). In phase-3, Psychometric tests (Cronbach's alpha, item and factor analysis) were performed among 400 adolescents. In phase-4, reliability was assessed (n = 30) using the Intra-class Correlation Coefficient (ICC) and Bland-Altman plot was tested and in Phase-5, the tool was graded using tertile-based stratification. RESULTS: The initial item pool included 98 items into two domains - Cognitive and Skill-based for creating framework. The cognitive-domain had one dimension- Knowledge; whereas, the skill-domain had three dimensions-(i)functional, (ii)interactive and (iii)critical. Content validity and cognitive interviews eliminated 13 items. The item difficulty (p) and item discrimination (D) indices ranged 0.10-0.98 and 0.00-0.88, respectively, with strong internal consistency (Cronbach's alpha = 0.81). Due to sample size limitations, factor analysis was used only for item reduction. These steps further reduced 12 items, resulting in a 73-item pool. The ICC was 0.895, and Bland-Altman plots revealed negligible mean biases indicating good reliability. The scores were categorized as low (/=56) out of 73. CONCLUSION: The INFOLIT is a validated and culturally relevant tool for assessing adolescent NFL and can be adapted for use in various Indian regions and contexts after minor modifications. CI - Copyright (c) 2025 Yadav, Konapur, Mokalla and Gavaravarapu. FAU - Yadav, Simran AU - Yadav S AD - Nutrition Information, Communication and Health Education (NICHE) Division, Indian Council of Medical Research-National Institute of Nutrition, Hyderabad, Telangana, India. FAU - Konapur, Archana AU - Konapur A AD - Nutrition Information, Communication and Health Education (NICHE) Division, Indian Council of Medical Research-National Institute of Nutrition, Hyderabad, Telangana, India. FAU - Mokalla, Thirupathi Reddy AU - Mokalla TR AD - Nutrition Information, Communication and Health Education (NICHE) Division, Indian Council of Medical Research-National Institute of Nutrition, Hyderabad, Telangana, India. FAU - Gavaravarapu, SubbaRao M AU - Gavaravarapu SM AD - Nutrition Information, Communication and Health Education (NICHE) Division, Indian Council of Medical Research-National Institute of Nutrition, Hyderabad, Telangana, India. LA - eng PT - Journal Article DEP - 20251113 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12671486 OTO - NOTNLM OT - adolescents OT - content validity OT - food literacy OT - health literacy OT - nutrition literacy OT - tool development COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/04 06:27 MHDA- 2025/12/04 06:28 PMCR- 2025/11/13 CRDT- 2025/12/04 04:44 PHST- 2025/05/11 00:00 [received] PHST- 2025/09/22 00:00 [accepted] PHST- 2025/12/04 06:28 [medline] PHST- 2025/12/04 06:27 [pubmed] PHST- 2025/12/04 04:44 [entrez] PHST- 2025/11/13 00:00 [pmc-release] AID - 10.3389/fnut.2025.1626673 [doi] PST - epublish SO - Front Nutr. 2025 Nov 13;12:1626673. doi: 10.3389/fnut.2025.1626673. eCollection 2025. PMID- 41340519 OWN - NLM STAT- MEDLINE DCOM- 20260204 LR - 20260506 IS - 1365-2788 (Electronic) IS - 0964-2633 (Print) IS - 0964-2633 (Linking) VI - 70 IP - 3 DP - 2026 Feb TI - Reliability of Actigraphy for the Assessment of Sleep and Circadian Rhythms in Rett and Related Syndromes. PG - 262-273 LID - 10.1111/jir.70068 [doi] AB - PURPOSE: Actigraphy is being increasingly used to assess sleep and circadian rhythms among populations with intellectual and developmental disabilities and genetic syndromes, including Rett syndrome and related disorders, but the reliability of these measures in these populations is unclear. The primary purpose of the current study was to evaluate the impact of recording duration on the reliability of various measures of sleep and circadian rhythm in Rett and related syndromes. METHOD: Two 14-day recordings were collected between 4 and 12 weeks apart in a sample of 30 individuals (aged 2-36 years; 97% female). Reliability was estimated by calculating statistics based on 3, 5, 7, 10 or 13-14 nights of recording. RESULTS: Most measures of average sleep quality could be reliably estimated with 7-10 nights. Measures of night-to-night variability in sleep timing showed poor reliability at all recording durations, whereas night-to-night variability in sleep duration showed adequate reliability at 5-7 days of recording. The reliability of measures of circadian rhythm was highly variable. CONCLUSIONS: The results suggest that the optimal recording durations for actigraphy in this population vary based on the specific metrics of interest, but most can be measured reliably. CI - (c) 2025 The Author(s). Journal of Intellectual Disability Research published by MENCAP and John Wiley & Sons Ltd. FAU - Byiers, Breanne AU - Byiers B AUID- ORCID: 0000-0002-7645-1479 AD - Department of Educational Psychology, University of Minnesota, Minneapolis, Minnesota, USA. FAU - Merbler, Alyssa AU - Merbler A AUID- ORCID: 0000-0002-8038-3368 AD - Department of Educational Psychology, University of Minnesota, Minneapolis, Minnesota, USA. FAU - Lockhart, Elijah AU - Lockhart E AD - Department of Educational Psychology, University of Minnesota, Minneapolis, Minnesota, USA. FAU - Burkitt, Chantel AU - Burkitt C AUID- ORCID: 0000-0002-1250-181X AD - Gillette Children's, St. Paul, Minnesota, USA. FAU - Symons, Frank AU - Symons F AUID- ORCID: 0000-0001-9833-4807 AD - Department of Educational Psychology, University of Minnesota, Minneapolis, Minnesota, USA. LA - eng GR - R21 HD101075/HD/NICHD NIH HHS/United States GR - R21HD101075/National Institutes of Child Health and Human Development/ PT - Journal Article DEP - 20251204 PL - England TA - J Intellect Disabil Res JT - Journal of intellectual disability research : JIDR JID - 9206090 SB - IM MH - Humans MH - *Actigraphy/standards/methods MH - Female MH - *Rett Syndrome/physiopathology MH - Child MH - Adolescent MH - Young Adult MH - Adult MH - Child, Preschool MH - Male MH - *Circadian Rhythm/physiology MH - Reproducibility of Results MH - Sleep Quality PMC - PMC12872378 OTO - NOTNLM OT - Rett syndrome OT - actigraphy OT - intellectual and developmental disabilities OT - reliability COIS- The authors declare no conflicts of interest. EDAT- 2025/12/04 06:27 MHDA- 2026/02/05 00:30 PMCR- 2026/02/05 CRDT- 2025/12/04 03:24 PHST- 2025/11/14 00:00 [revised] PHST- 2025/05/12 00:00 [received] PHST- 2025/11/20 00:00 [accepted] PHST- 2026/02/05 00:30 [medline] PHST- 2025/12/04 06:27 [pubmed] PHST- 2025/12/04 03:24 [entrez] PHST- 2026/02/05 00:00 [pmc-release] AID - JIR70068 [pii] AID - 10.1111/jir.70068 [doi] PST - ppublish SO - J Intellect Disabil Res. 2026 Feb;70(3):262-273. doi: 10.1111/jir.70068. Epub 2025 Dec 4. PMID- 41340380 OWN - NLM STAT- MEDLINE DCOM- 20251204 LR - 20260506 IS - 2148-5607 (Electronic) IS - 1300-4948 (Print) IS - 1300-4948 (Linking) VI - 36 IP - 12 DP - 2025 Nov 12 TI - Can Creeping Fat Be a Prognostic Factor in Crohn's Disease? PG - 834-843 LID - 10.5152/tjg.2025.25259 [doi] AB - BACKGROUND/AIMS: The aim of this study is to investigate whether the creeping fat (CF) finding evaluated by computed tomography (CT) can be used as a noninvasive marker to predict disease prognosis. MATERIALS AND METHODS: The study comprised 128 Crohn's patients, aged 18-70, who had CT scanning for a variety of reasons. Patients were retrospectively analyzed in 3 groups (31 patients with operation due to stenosis, 39 patients with unoperated stenosis, and 44 patients without stenosis). The CF Index BSACR (bowel surface area coverage ratio), CF density, and visceral-subcutaneous fat ratio (VSFR) findings were evaluated by CT compared between the groups. RESULTS: The median VSFR was higher in the stenosed group compared to the non-stenosed group (0.7 vs 0.4; P = .003). The CF index BSACR was 37.5% (27.1% vs 18.2%; P = .001), and the rate of those with a CF index BSACR above 37.5% was higher in those with stenosis compared to those without. The odds of stenosis were 17.07 times (odds ratio [OR] = 17.07; P = .007) higher in those with a CF index BSACR of 37.5% and 184.57 times (OR = 184.57; P = .001) higher in those with a CF index BSACR of 50% or more compared to those with no involvement or a CF index BSACR of 25% or less. CONCLUSION: The CF index correlated with stricturing disease and may be a noninvasive radiologic marker that predicts disease prognosis. CI - Creative Commons Attribution (CC BY) 4.0 International License. FAU - Demiral, Naime AU - Demiral N AUID- ORCID: 0000-0003-4145-9814 AD - Department of Internal Medicine, Ankara Bilkent City Hospital, Ankara, Turkiye. FAU - Edis Ozdemir, Fatma Ayca AU - Edis Ozdemir FA AUID- ORCID: 0000-0002-0172-6837 AD - Department of Radiology, Ankara Bilkent City Hospital, Ankara, Turkiye. FAU - Kivrakoglu, Fatih AU - Kivrakoglu F AUID- ORCID: 0000-0002-5388-794X AD - Department of Gastroenterology, Osmaniye State Hospital, Ankara, Turkiye. FAU - Tayfur Yurekli, Oyku AU - Tayfur Yurekli O AUID- ORCID: 0000-0002-1295-152X AD - Department of Gastroenterology, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, Turkiye. FAU - Akin, Fatma Ebru AU - Akin FE AUID- ORCID: 0000-0002-5934-2334 AD - Department of Gastroenterology, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, Turkiye. FAU - Tahtaci, Mustafa AU - Tahtaci M AUID- ORCID: 0000-0003-4046-3715 AD - Department of Gastroenterology, Ankara Yildirim Beyazit University Faculty of Medicine, Ankara, Turkiye. FAU - Sarialtin, Firathan AU - Sarialtin F AUID- ORCID: 0000-0002-7771-9094 AD - Department of Radiology, Ankara Bilkent City Hospital, Ankara, Turkiye. LA - eng PT - Journal Article PL - Turkey TA - Turk J Gastroenterol JT - The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology JID - 9515841 SB - IM MH - Humans MH - *Crohn Disease/diagnostic imaging/pathology/complications MH - Male MH - Female MH - Adult MH - Retrospective Studies MH - Prognosis MH - Middle Aged MH - Adolescent MH - *Tomography, X-Ray Computed MH - Young Adult MH - Aged MH - Constriction, Pathologic/diagnostic imaging/etiology MH - *Intra-Abdominal Fat/diagnostic imaging MH - *Intestinal Obstruction/etiology/diagnostic imaging MH - Predictive Value of Tests PMC - PMC12684276 OTO - NOTNLM OT - Adipose tissue OT - Crohn's disease OT - obesity OT - stricture OT - subcutaneous fat OT - visceral fat COIS- Declaration of Interests: The authors have no conflicts of interest to declare. EDAT- 2025/12/04 06:26 MHDA- 2025/12/04 06:27 PMCR- 2025/11/12 CRDT- 2025/12/04 02:16 PHST- 2025/12/04 06:27 [medline] PHST- 2025/12/04 06:26 [pubmed] PHST- 2025/12/04 02:16 [entrez] PHST- 2025/11/12 00:00 [pmc-release] AID - tjg-36-12-834 [pii] AID - 10.5152/tjg.2025.25259 [doi] PST - ppublish SO - Turk J Gastroenterol. 2025 Nov 12;36(12):834-843. doi: 10.5152/tjg.2025.25259. PMID- 41340135 OWN - NLM STAT- MEDLINE DCOM- 20261009 LR - 20261009 IS - 1755-3768 (Electronic) IS - 1755-375X (Linking) VI - 104 IP - 7 DP - 2026 Nov TI - Validation of the 'TWO-ROP' algorithm in a tertiary Care Centre in Greece. PG - e841-e845 LID - 10.1111/aos.70053 [doi] AB - PURPOSE: The TWO-ROP algorithm is a modified screening protocol based on US data for low-risk infants that limits screening to a single outpatient exam at 38 or 40 weeks to reduce the retinopathy of prematurity (ROP) screening burden without compromising safety. The aim of this study was to validate the algorithm on an external data set outside the United States. METHODS: This is a retrospective study of premature infants screened for ROP at a tertiary centre in Greece. Infants with higher birth weight (BW) and greater gestational age (GA) were included and stratified into three groups: group 1 (BW < 1500 g, GA >/= 32 weeks), group 2 (BW >/= 1500 g, GA < 32 weeks) and group 3 (BW >/= 1500 g, GA >/= 32 weeks). The rate of ROP and type 1 ROP were evaluated. RESULTS: Five hundred and fifty-three of the 1251 infants (44.2%) met the inclusion criteria. Groups 1, 2 and 3 had 139 (25.1%), 283 (51.2%) and 131 (23.7%) patients. Fourteen patients (2.5%) had ROP, including 7 in group 1, 7in group 2 and 0 in group 3 (p < 0.001). No patient met the criteria for type 1 ROP. No cases of treatment warranted ROP (TW-ROP) were observed in the cohort, indicating no missed cases under the TWO-ROP algorithm. When applying the algorithm, 14.3%-14.9% (mean 14.6%) of ROP examinations were saved. CONCLUSION: The TWO-ROP algorithm can reduce examinations while ensuring safety in Greece when using the local screening guidelines. This is the first ex-US validation and supports the potential for risk-stratified screening globally to optimize resources while maintaining safety. CI - (c) 2025 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd. FAU - Moutzouri, Stella AU - Moutzouri S AD - Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Chaaya, Celine AU - Chaaya C AD - Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, USA. AD - Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Altamirano, Francisco AU - Altamirano F AD - Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Pandiri, Srujay AU - Pandiri S AD - University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA. FAU - Hoyek, Sandra AU - Hoyek S AUID- ORCID: 0000-0003-3922-360X AD - Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, USA. AD - Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Abousifein, Marfy AU - Abousifein M AD - Harvard Medical School, Boston, Massachusetts, USA. FAU - Brant, Arthur AU - Brant A AD - Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, USA. FAU - Vavvas, Demetrios G AU - Vavvas DG AD - Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, USA. FAU - Mataftsi, Asimina AU - Mataftsi A AD - Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Patel, Nimesh A AU - Patel NA AUID- ORCID: 0000-0002-6681-6104 AD - Department of Ophthalmology, Massachusetts Eye and Ear, Boston, Massachusetts, USA. AD - Department of Ophthalmology, Boston Children's Hospital, Boston, Massachusetts, USA. LA - eng PT - Journal Article PT - Validation Study DEP - 20251203 PL - England TA - Acta Ophthalmol JT - Acta ophthalmologica JID - 101468102 SB - IM MH - Humans MH - Greece/epidemiology MH - *Algorithms MH - *Tertiary Care Centers MH - Retrospective Studies MH - Infant, Newborn MH - *Retinopathy of Prematurity/diagnosis/epidemiology MH - Male MH - Female MH - *Neonatal Screening/methods MH - Gestational Age MH - Birth Weight MH - Infant, Premature MH - Reproducibility of Results OTO - NOTNLM OT - TWO-ROP algorithm OT - retinopathy of prematurity OT - screening OT - validation EDAT- 2025/12/04 06:27 MHDA- 2026/10/09 17:34 CRDT- 2025/12/04 00:12 PHST- 2025/08/21 00:00 [received] PHST- 2025/11/22 00:00 [accepted] PHST- 2026/10/09 17:34 [medline] PHST- 2025/12/04 06:27 [pubmed] PHST- 2025/12/04 00:12 [entrez] AID - 10.1111/aos.70053 [doi] PST - ppublish SO - Acta Ophthalmol. 2026 Nov;104(7):e841-e845. doi: 10.1111/aos.70053. Epub 2025 Dec 3. PMID- 41340055 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 26 IP - 1 DP - 2025 Dec 3 TI - Comparison of cone-beam computed tomography and panoramic radiography in estimating the 18-year age threshold: a retrospective study. PG - 29 LID - 10.1186/s12903-025-07428-7 [doi] LID - 29 AB - BACKGROUND: The third molar maturity index (I3M) method, introduced for application on panoramic radiographs, is used to assess whether an individual has reached the legal 18-year age threshold. This study aimed to evaluate the applicability of the I3M method to cone-beam computed tomography (CBCT) scans and to compare the results with those obtained from panoramic radiographs of the same patients. METHODS: Patients who had already received both CBCT scans and panoramic radiographs were selected retrospectively. The maturity index values of 418 mandibular third molars were obtained through measurements using both CBCT scans and panoramic radiographs. The accuracy of the I3M method for both radiological methods was evaluated using receiver operating characteristic (ROC) curve analysis. The sensitivity, specificity, misclassification rate, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio (PLR), negative likelihood ratio (NLR), and overall area under the ROC curve (AUROC) at the 95% confidence interval (CI) level were calculated as performance measures for both imaging modalities. RESULTS: Both imaging modalities showed excellent diagnostic performance, with AUROC values of 0.928 for CBCT and 0.932 for panoramic radiography. The sensitivity of CBCT was 82.0%, the specificity was 89.7%, and the misclassification rate was 14.1%. For panoramic radiography, the sensitivity was 85.1%, the specificity was 86.8%, and the misclassification rate was 18.1%. The PLR and NLR values for CBCT were 7.96 and 0.20, respectively, whereas those for panoramic radiography were 6.43 and 0.17, respectively. Additionally, the PPV and NPV values for CBCT were 0.943 and 0.705, respectively, and those for panoramic radiography were 0.930 and 0.738, respectively. CONCLUSIONS: The results indicated that the accuracy of the I3M method for CBCT scans was similar to that for panoramic radiographs from the same individuals. Importantly, the I3M method used to estimate the legal 18-year age threshold can also be used for CBCT scans, as it enables the use of existing CBCT images in age estimation studies. FAU - Diricanli, Munevver Gamze AU - Diricanli MG AUID- ORCID: 0000-0001-8378-2324 AD - Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey. munevverdiricanli@hacettepe.edu.tr. FAU - Akkaya, Nursel AU - Akkaya N AUID- ORCID: 0000-0002-2854-1138 AD - Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Hacettepe University, Ankara, Turkey. FAU - Zengin, Hatice Yagmur AU - Zengin HY AUID- ORCID: 0000-0002-9855-2449 AD - Department of Biostatistics, Faculty of Medicine, Hacettepe University, Sihhiye, Ankara, 06100, Turkey. LA - eng PT - Comparative Study PT - Journal Article DEP - 20251203 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - *Cone-Beam Computed Tomography MH - *Radiography, Panoramic MH - Adolescent MH - Retrospective Studies MH - *Molar, Third/diagnostic imaging/growth & development MH - *Age Determination by Teeth/methods MH - Female MH - Male MH - Sensitivity and Specificity MH - ROC Curve MH - Predictive Value of Tests PMC - PMC12781838 OTO - NOTNLM OT - Age estimation OT - CBCT OT - Forensic dentistry OT - Panoramic radiography OT - Third molar maturity index OT - Turkey COIS- Declarations. Ethics approval and consent to participate: This study (Research Number: SBA 23/248) was conducted in accordance with the ethical standards of the Declaration of Helsinki and was approved by the Hacettepe University Health Sciences Research Ethics Committee (Session Date: October 24, 2023; Session No: 2023/05; Decision No: 2023/05-13). This is a retrospective archive study. However, informed consent is obtained from all patients examined in our clinic. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/04 02:11 MHDA- 2026/06/27 00:56 PMCR- 2025/12/03 CRDT- 2025/12/03 23:57 PHST- 2025/09/15 00:00 [received] PHST- 2025/11/24 00:00 [accepted] PHST- 2026/06/27 00:56 [medline] PHST- 2025/12/04 02:11 [pubmed] PHST- 2025/12/03 23:57 [entrez] PHST- 2025/12/03 00:00 [pmc-release] AID - 10.1186/s12903-025-07428-7 [pii] AID - 7428 [pii] AID - 10.1186/s12903-025-07428-7 [doi] PST - epublish SO - BMC Oral Health. 2025 Dec 3;26(1):29. doi: 10.1186/s12903-025-07428-7. PMID- 41339761 OWN - NLM STAT- MEDLINE DCOM- 20251204 LR - 20261009 IS - 1432-1076 (Electronic) IS - 0340-6199 (Linking) VI - 184 IP - 12 DP - 2025 Dec 3 TI - Dietary phytochemical intake and asthma in children: a case-control study. PG - 818 LID - 10.1007/s00431-025-06634-3 [doi] AB - Pediatric asthma is a chronic inflammatory disease marked by bronchial hyperresponsiveness and airflow obstruction. Diet may be associated with asthma risk and severity through anti-inflammatory and antioxidant effects. This research evaluated the connection between the Dietary Phytochemical Index (DPI), which measures the percentage of daily calories from foods high in phytochemicals, and asthma-related outcomes in pediatric populations. In this case-control study with cross-sectional analyses within the asthma group, 300 children aged 5-12 years (150 asthma cases, 150 matched controls) were evaluated. Dietary intake was measured via a validated food frequency questionnaire. DPI was calculated and categorized into tertiles. Clinical outcomes included the Pediatric Asthma Severity Score (PASS), Childhood Asthma Control Test (C-ACT), and Pediatric Asthma Quality of Life Questionnaire (PAQLQ). Serum C-reactive protein (CRP) was measured as an inflammation marker. Children in the highest DPI tertile had lower CRP levels (1.99 vs. 4.02 mg/L), higher PAQLQ scores (4.33 vs. 3.89), lower PASS scores (6.35 vs. 11.14), and higher C-ACT scores (21.45 vs. 13.91; all p < 0.001) than those in the lowest tertile. Higher DPI was associated with lower inflammation (CRP: beta = -0.026), higher quality of life (PAQLQ: beta = 0.058), lower asthma severity (PASS: beta = -0.148), and higher asthma control (C-ACT: beta = 0.364; all p < 0.001). The highest DPI tertile was associated with lower odds of asthma (OR = 0.06; 95% CI: 0.03-0.13; p < 0.001) (fully adjusted for age, sex, BMI, physical activity, energy intake, fiber, and vitamin D). Each one-unit DPI increase was associated with 11% lower odds of asthma (OR = 0.89; 95% CI: 0.86-0.91; p < 0.001), with CRP as the primary inflammation marker assessed. CONCLUSION: Greater intake of phytochemical-rich foods is associated with lower odds of asthma, lower inflammation, and better clinical outcomes in children. WHAT IS KNOWN: * Dietary patterns rich in anti-inflammatory foods may benefit children with asthma. * Phytochemicals have antioxidant and immune-modulating effects relevant to asthma. WHAT IS NEW: * Higher Dietary Phytochemical Index was associated with substantially lower odds of pediatric asthma. * Higher DPI was also associated with lower asthma severity, better asthma control, and lower CRP. * This is the first study to apply DPI to a pediatric asthma population. CI - (c) 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. FAU - Jiang, Renpeng AU - Jiang R AD - Department of Pediatrics, Shandong Provincial Third Hospital, No. 11 Wuying Mountain Middle Road, Tianqiao District, Jinan City, 250031, Shandong Province, China. FAU - Liu, Weihong AU - Liu W AD - Department of Pediatrics, Shandong Provincial Third Hospital, No. 11 Wuying Mountain Middle Road, Tianqiao District, Jinan City, 250031, Shandong Province, China. FAU - Wang, Guangjun AU - Wang G AD - Department of Pediatrics, Shandong Provincial Third Hospital, No. 11 Wuying Mountain Middle Road, Tianqiao District, Jinan City, 250031, Shandong Province, China. guangjun2010@126.com. LA - eng PT - Journal Article DEP - 20251203 PL - Germany TA - Eur J Pediatr JT - European journal of pediatrics JID - 7603873 RN - 0 (Phytochemicals) RN - 9007-41-4 (C-Reactive Protein) RN - 0 (Biomarkers) SB - IM MH - Humans MH - *Asthma MH - Child MH - Male MH - Female MH - Case-Control Studies MH - Child, Preschool MH - Cross-Sectional Studies MH - Quality of Life MH - *Phytochemicals/administration & dosage MH - *Diet MH - Severity of Illness Index MH - C-Reactive Protein/analysis MH - Biomarkers/blood OTO - NOTNLM OT - Asthma OT - Child OT - Diet OT - Inflammation OT - Phytochemicals COIS- Declarations. Ethics approval and consent to participate: Ethics approval was obtained from the Ethics Committee of the Shandong Provincial Third Hospital (Approval No: KYLL-2025208). Written informed consent was obtained from all participants. All procedures were conducted in accordance with the Declaration of Helsinki. Consent for publication: All authors endorse the submission of this manuscript to the journal. Patient consent for publication: Not applicable. Competing interest: The authors declare no competing interests. EDAT- 2025/12/04 02:11 MHDA- 2025/12/04 06:26 CRDT- 2025/12/03 23:41 PHST- 2025/08/13 00:00 [received] PHST- 2025/11/10 00:00 [accepted] PHST- 2025/11/04 00:00 [revised] PHST- 2025/12/04 06:26 [medline] PHST- 2025/12/04 02:11 [pubmed] PHST- 2025/12/03 23:41 [entrez] AID - 10.1007/s00431-025-06634-3 [pii] AID - 10.1007/s00431-025-06634-3 [doi] PST - epublish SO - Eur J Pediatr. 2025 Dec 3;184(12):818. doi: 10.1007/s00431-025-06634-3. PMID- 41339064 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20251214 IS - 1347-4715 (Electronic) IS - 1342-078X (Print) IS - 1342-078X (Linking) VI - 30 DP - 2025 TI - Prediction of one-day creatinine excretion in Japanese schoolchildren based on anthropometric measurements. PG - 97 LID - 10.1265/ehpm.25-00250 [doi] LID - 97 AB - BACKGROUND: The creatinine (Cre) concentration in urine is used as an adjustment factor in chemical exposure and nutritional intake assessments. Because Cre excretion varies by sex, age, race, and anthropometric measurements such as height and weight, developing a method suitable for estimating one-day Cre excretion is necessary. Accordingly, this study aimed to develop a predictive equation for individual one-day Cre excretion in Japanese school children. METHODS: Urine samples were collected from 113 boys and 91 girls (aged 6-12 years) from the Aichi Prefecture, Japan, who were free from diseases affecting the renal, muscle, or nervous systems. Urinary concentrations and one-day excreted amounts of Cre were measured and compared with the values obtained using previously reported equations or a fixed value, totaling 11 methods. Subsequently, we developed a new equation using machine learning and multiple regression analyses. Additionally, the estimated one-day sodium excretion value calculated using this equation was compared with the measured value. RESULTS: Among the 11 methods to predict Cre excretion, 7 overestimated-5 of which showed a positive trend bias with larger differences at higher average concentrations-and 3 underestimated-2 of which showed a negative trend bias with larger differences at lower average concentrations. A new machine learning model using sex, age, and body surface area (calculated from height and weight) yielded the most accurate prediction. Multiple regression analysis, which demonstrated the most accurate prediction, used sex, age, and body surface area as independent variables with or without the first void Cre concentration divided by urination duration from the previous night's urination to the first void. Moreover, the difference in one-day sodium excretion from first-void urine predicted using our newly developed Cre equation increased as the measured values increased. CONCLUSIONS: Our study suggests that the estimation of one-day Cre excretion based on sex, age, and body surface area is most appropriate for Japanese schoolchildren, particularly in assessing their chemical exposure and dietary nutrient intake. TRIAL REGISTRATION: Trial registration is not applicable as this observational study did not involve any intervention or randomization requiring registration in a clinical trials registry. FAU - Kato, Sayaka AU - Kato S AD - Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences. FAU - Ito, Yuki AU - Ito Y AUID- ORCID: 0000-0003-1617-1595 AD - Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences. FAU - Nakagawa, Asako AU - Nakagawa A AD - Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences. FAU - Minato, Kyoko AU - Minato K AD - Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences. FAU - Aktar, Mst Sarmin AU - Aktar MS AD - Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences. FAU - Miyake, Mio AU - Miyake M AD - Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences. FAU - Nakane, Shogo AU - Nakane S AD - Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences. FAU - Kamijima, Michihiro AU - Kamijima M AD - Department of Occupational and Environmental Health, Nagoya City University Graduate School of Medical Sciences. LA - eng PT - Journal Article PL - Japan TA - Environ Health Prev Med JT - Environmental health and preventive medicine JID - 9609642 RN - AYI8EX34EU (Creatinine) RN - Japanese people SB - IM MH - Humans MH - Child MH - Female MH - Male MH - Japan MH - *Creatinine/urine MH - *Anthropometry MH - East Asian People PMC - PMC12698365 OTO - NOTNLM OT - Bland-Altman plot OT - Creatinine excretion OT - Japanese schoolchildren OT - Predictive equation OT - Urinary excretion COIS- The authors declare that they have no competing interests. EDAT- 2025/12/04 02:11 MHDA- 2025/12/04 02:12 PMCR- 2025/12/04 CRDT- 2025/12/03 21:36 PHST- 2025/12/04 02:12 [medline] PHST- 2025/12/04 02:11 [pubmed] PHST- 2025/12/03 21:36 [entrez] PHST- 2025/12/04 00:00 [pmc-release] AID - 25-00250 [pii] AID - 10.1265/ehpm.25-00250 [doi] PST - ppublish SO - Environ Health Prev Med. 2025;30:97. doi: 10.1265/ehpm.25-00250. PMID- 41338958 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20260919 IS - 1440-6047 (Electronic) IS - 0964-7058 (Print) IS - 0964-7058 (Linking) VI - 34 IP - 6 DP - 2026 Dec TI - Predictors of carotenoid status in New Zealand children using carotenoid reflection score: a cross-sectional study. PG - 1007-1018 LID - 10.6133/apjcn.202512_34(6).0014 [doi] AB - BACKGROUND AND OBJECTIVES: Optically-assessed skin carotenoid status offers an objective measure of vegetable and fruit intake. Data from the Sodium and Potassium Intake (SNaK+) study was used to explore asso-ciations of carotenoid reflection scores with body size, annual household income, vegetable and fruit intake and potassium intake, and the relationship between carotenoid reflection score and 24-h urinary potassium in children. METHODS AND STUDY DESIGN: Seventy-five children (29 girls, 37 boys; 9 not stated) aged 8 to 13 years from five New Zealand primary schools were supported by the parents/caregivers to complete validated questions about their frequency of vegetable and fruit intake. Carotenoid reflection scores were measured using reflection spectroscopy and 24-h urine samples (n = 69) were collected. Differences by gender and age were tested using two-sample t-tests. Linear regression identified determinants of carotenoid reflection score. RESULTS: Children's overall mean (standard deviation) carotenoid reflection score was 236 (91), with 51% having low scores (< 250). Younger boys (< 10 years) had higher carotenoid reflection scores than younger girls (mean difference (95% confidence interval); 74 (4, 144). Few (8%, n = 6) children met vegetable intake recommendations. Annual household income and fruit servings per day were predictive correlates of carote-noid reflection scores (R2 = 0.17, F(2.52) = 6.10, p <0.01). Twenty-four-hour urinary potassium did not correlate with carotenoid reflection score. CONCLUSIONS: This study identified low household income and low fruit intake as drivers of low carotenoid status in children, emphasizing the need for targeted dietary interventions. A study is required to further explore the relationship between carotenoid reflection score and potassium excretion. FAU - Rapson, Jeanette AU - Rapson J AD - Department of Epidemiology and Biostatistics, The Centre for Translational Health Research: Informing Policy and Practice (TRANSFORM), The University of Auckland, Auckland, New Zealand. Email: jeanette.rapson@auckland.ac.nz. FAU - Rush, Elaine AU - Rush E AD - Faculty of Health and Environmental Studies, Auckland University of Technology, Auckland, New Zealand. AD - Riddet Centre of Research Excellence, Palmerston North, New Zealand. FAU - McLean, Rachael AU - McLean R AD - Department of Preventive and Social Medicine, The University of Otago, Dunedin, New Zealand. FAU - Fuavao, Kava AU - Fuavao K AD - Department of Epidemiology and Biostatistics, The Centre for Translational Health Research: Informing Policy and Practice (TRANSFORM), The University of Auckland, Auckland, New Zealand. FAU - Wall, Clare AU - Wall C AD - Department of Nutrition and Dietetics, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. FAU - Eyles, Helen AU - Eyles H AD - Department of Epidemiology and Biostatistics, The Centre for Translational Health Research: Informing Policy and Practice (TRANSFORM), The University of Auckland, Auckland, New Zealand. LA - eng GR - #1821/Heart Foundation of New Zealand/ PT - Journal Article PL - China TA - Asia Pac J Clin Nutr JT - Asia Pacific journal of clinical nutrition JID - 9440304 RN - 36-88-4 (Carotenoids) RN - RWP5GA015D (Potassium) SB - IM MH - Humans MH - *Carotenoids/urine/analysis MH - Male MH - Female MH - Child MH - New Zealand MH - Cross-Sectional Studies MH - Adolescent MH - Vegetables MH - Fruit MH - *Diet MH - *Nutritional Status MH - Potassium/urine PMC - PMC12664544 OTO - NOTNLM OT - Veggie Meter OT - children OT - potassium OT - reflection spectroscopy OT - vegetable consumption COIS- The authors declare no conflict of interest. HE was a Heart Foundation of New Zealand Senior Fellow (#1843) EDAT- 2025/12/04 02:11 MHDA- 2025/12/04 02:12 PMCR- 2025/11/26 CRDT- 2025/12/03 21:22 PHST- 2025/12/04 02:12 [medline] PHST- 2025/12/04 02:11 [pubmed] PHST- 2025/12/03 21:22 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - 10.6133/apjcn.202512_34(6).0014 [doi] PST - ppublish SO - Asia Pac J Clin Nutr. 2026 Dec;34(6):1007-1018. doi: 10.6133/apjcn.202512_34(6).0014. PMID- 41338957 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20251207 IS - 1440-6047 (Electronic) IS - 0964-7058 (Print) IS - 0964-7058 (Linking) VI - 34 IP - 6 DP - 2025 Dec TI - Applicability of different resting energy expenditure prediction equations to overweight and obese women of childbearing age with fertility problems. PG - 999-1006 LID - 10.6133/apjcn.202512_34(6).0013 [doi] AB - BACKGROUND AND OBJECTIVES: This study compared the accuracy of current energy formulas in predicting resting energy expenditure (REE) in overweight and obese women with fertility problems. METHODS AND STUDY DESIGN: This study evaluated REE prediction formulas in 82 overweight/obese women (18-49 years) with fertility problems. REE is accurately measured using indirect calorimetry, which is considered the gold standard for evaluating energy. Anthropometric data, including height, weight, and waist circumference. Body composition analysis was performed using bioelectrical impedance analysis to determine fat-free mass and other related indicators. Statistical analyses included Spearman correlation coefficients to assess the relationship between REE and various predictors. The accuracy and reliability of the existing prediction equations were evaluated by comparing their predicted values with resting energy expenditure values measured by Indirect Calorimetry using Bland-Altman analysis. RESULTS: Among the prediction equations assessed, Mifflin's equation demonstrated superior performance in estimating REE in overweight/obese women experiencing fertility problems, exhibiting the least bias (-9.7 kcal/day) and a low standard deviation (240 kcal/day). Variables such as body weight, lean body weight, and central obesity indicators like waist circumference and waist-height ratio emerged as significant predictors of REE, with their impacts being age-dependent. The Mifflin-St. Jeor Equation, which integrates weight, height, and age variables, offers a reasonably accurate estimation of energy needs for this specific demographic. CONCLUSIONS: The Mifflin-St. Jeor Equation is an accurate tool for predicting REE in overweight and obese women with fertility problems, offering important insights for nutritional assessment and intervention strategies in fertility management. FAU - Wu, Xuanhui AU - Wu X AD - Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China. AD - School of Public Health, Hebei Medical University, Shijiazhuang, China. AD - Hebei Key Laboratory of Nutrition and Health, Shijiazhuang, China. FAU - Xue, Hongmei AU - Xue H AD - Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China. AD - Hebei Key Laboratory of Nutrition and Health, Shijiazhuang, China. FAU - Liang, Mingyue AU - Liang M AD - Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China. AD - School of Public Health, Hebei Medical University, Shijiazhuang, China. AD - Hebei Key Laboratory of Nutrition and Health, Shijiazhuang, China. FAU - Wang, Ying AU - Wang Y AD - Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China. AD - School of Public Health, Hebei Medical University, Shijiazhuang, China. AD - Hebei Key Laboratory of Nutrition and Health, Shijiazhuang, China. FAU - Xie, Ying AU - Xie Y AD - Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China. AD - Hebei Key Laboratory of Nutrition and Health, Shijiazhuang, China. FAU - Zhai, Yijing AU - Zhai Y AD - Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China. AD - Hebei Key Laboratory of Nutrition and Health, Shijiazhuang, China. FAU - Xu, Bianling AU - Xu B AD - Department of Obstetrics and Gynecology, The First Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Song, Chao AU - Song C AD - National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, China. FAU - Li, Xiaodong AU - Li X AD - Department of Obstetrics and Gynecology, The First Hospital of Hebei Medical University, Shijiazhuang, China. FAU - Lai, Jianqiang AU - Lai J AD - Chinese Center for Disease Control and Prevention, Beijing, China. FAU - Li, Zengning AU - Li Z AD - Department of Clinical Nutrition, The First Hospital of Hebei Medical University, Shijiazhuang, China. Email: zengningli@hebmu.edu.cn. AD - School of Public Health, Hebei Medical University, Shijiazhuang, China. AD - Hebei Key Laboratory of Nutrition and Health, Shijiazhuang, China. LA - eng GR - No.2025033/Scientific Research Project Plan of Traditional Chinese Medicine in Hebei Province/ GR - CNS-NNSRG2022-231/National Nutrition Research Foundation of Chinese Nutrition Society/ GR - No.H2023206219/Natural Science Foundation of Hebei Province/ PT - Journal Article PL - China TA - Asia Pac J Clin Nutr JT - Asia Pacific journal of clinical nutrition JID - 9440304 SB - IM MH - Humans MH - Female MH - Adult MH - *Obesity/metabolism/complications MH - *Overweight/metabolism/complications MH - Middle Aged MH - Adolescent MH - Young Adult MH - *Energy Metabolism/physiology MH - *Basal Metabolism/physiology MH - Calorimetry, Indirect MH - Body Composition PMC - PMC12664540 OTO - NOTNLM OT - energy expenditure OT - fertility problems OT - overweight and obese OT - prediction equations OT - women COIS- The authors declare no conflict of interest EDAT- 2025/12/04 02:11 MHDA- 2025/12/04 02:12 PMCR- 2025/11/26 CRDT- 2025/12/03 21:22 PHST- 2025/12/04 02:12 [medline] PHST- 2025/12/04 02:11 [pubmed] PHST- 2025/12/03 21:22 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - 10.6133/apjcn.202512_34(6).0013 [doi] PST - ppublish SO - Asia Pac J Clin Nutr. 2025 Dec;34(6):999-1006. doi: 10.6133/apjcn.202512_34(6).0013. PMID- 41338956 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20260919 IS - 1440-6047 (Electronic) IS - 0964-7058 (Print) IS - 0964-7058 (Linking) VI - 34 IP - 6 DP - 2025 Dec TI - Association between plant dietary fiber intake and hyperuricemia risk in Chinese children aged 6-17 years. PG - 991-998 LID - 10.6133/apjcn.202512_34(6).0012 [doi] AB - BACKGROUND AND OBJECTIVES: The increasing prevalence of hyperuricemia in children is a global health con-cern. Plant dietary fiber may influence uric acid levels by improving gut health and lowering blood glucose and lipid levels. This study aims to examine the relationship between plant-based dietary fiber intake and hyperuricemia risk in Chinese children aged 6-17 years. METHODS AND STUDY DESIGN: This study analyzed di-etary fiber intake data from 11,423 children (aged 6-17 years) from the China Children and Lactating Wom-en Nutrition and Health Surveillance (CCLWNHS) conducted between 2016 and 2019. Plant dietary fiber intake was assessed using a food frequency questionnaire. Logistic regression was performed, adjusting for age, sex, body mass index (BMI), smoking, alcohol consumption, physical activity, and energy intake. Restricted cubic splines (RCS) and receiver operating characteristic (ROC) curves were utilized to explore nonlinear relationships and identify cut-off values for dietary fiber intake. RESULTS: Among the 11,423 children, 1,730 (15.1%) were diagnosed with hyperuricemia. The average daily fiber intake was 8.28 +/- 5.90g, with cereal fiber accounting for 56.1-57.8%. A significant negative correlation was found between cereal dietary fiber intake and hyperuricemia risk (p = 0.0004). Stratified analysis indicated that overweight/obesity status modi-fied this relationship. ROC curve analysis identified optimal intake cut-off values: 8.35 g/day for boys and 11.1 g/day for girls. CONCLUSIONS: Processed and ultraprocessed foods still have a lower contribution to ener-gy and nutrient intake in Jakarta than nonprocessed foods and processed ingredients. FAU - Yu, Lianlong AU - Yu L AD - Shandong Center for Disease Control and Prevention, Ji'nan, Shandong, China. AD - School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China. AD - Jinan Fruit Research Institute, All-China Federation of Supply and Marketing Co-Operatives, Jinan, China. FAU - Liu, Zhaolu AU - Liu Z AD - Shandong Center for Disease Control and Prevention, Ji'nan, Shandong, China. FAU - Liu, Lei AU - Liu L AD - Shandong Center for Disease Control and Prevention, Ji'nan, Shandong, China. FAU - Liu, Changqing AU - Liu C AD - Hebei Center for Disease Control and Prevention, Shijiazhuang, China. FAU - Ma, Chao AU - Ma C AD - Jinan Fruit Research Institute, All-China Federation of Supply and Marketing Co-Operatives, Jinan, China. FAU - Zheng, Xiaodong AU - Zheng X AD - Jinan Fruit Research Institute, All-China Federation of Supply and Marketing Co-Operatives, Jinan, China. FAU - Zhang, Ming AU - Zhang M AD - Jinan Fruit Research Institute, All-China Federation of Supply and Marketing Co-Operatives, Jinan, China. FAU - Liu, Yiya AU - Liu Y AD - Guizhou Center for Disease Control and Prevention, Guiyang, China. FAU - Tian, Meina AU - Tian M AD - Hebei Center for Disease Control and Prevention, Shijiazhuang, China. FAU - Luo, Xiaoyan AU - Luo X AD - Hebei Center for Disease Control and Prevention, Shijiazhuang, China. FAU - Zhu, Qianrang AU - Zhu Q AD - Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China. FAU - Zhao, Xiulan AU - Zhao X AD - Shandong Center for Disease Control and Prevention, Ji'nan, Shandong, China. Email: zhao.xl@sdu.edu.cn. FAU - Wu, Maoyu AU - Wu M AD - Jinan Fruit Research Institute, All-China Federation of Supply and Marketing Co-Operatives, Jinan, China. Email: wmyu1972@163.com. LA - eng GR - ZR2023QH157/Qilu Health Outstanding Young Talents Project, Shandong Provincial Natural Science Foundation/ GR - 2020Q041/Chinese Medicine Science and Technology Project of Shandong Province/ GR - 2020Q043/Chinese Medicine Science and Technology Project of Shandong Province/ GR - 202412021239/Shandong Medical and Health Science and Technology Development Project/ PT - Journal Article PL - China TA - Asia Pac J Clin Nutr JT - Asia Pacific journal of clinical nutrition JID - 9440304 RN - 0 (Dietary Fiber) RN - Chinese people SB - IM MH - Humans MH - Child MH - *Dietary Fiber/administration & dosage MH - *Hyperuricemia/epidemiology MH - Female MH - Male MH - Adolescent MH - China/epidemiology MH - Risk Factors MH - *Diet MH - East Asian People PMC - PMC12664538 OTO - NOTNLM OT - cereals dietary fiber OT - children OT - consumption OT - dietary fiber OT - hyperuricemia COIS- The authors declare no conflicts of interest EDAT- 2025/12/04 02:11 MHDA- 2025/12/04 02:12 PMCR- 2025/11/26 CRDT- 2025/12/03 21:22 PHST- 2025/12/04 02:12 [medline] PHST- 2025/12/04 02:11 [pubmed] PHST- 2025/12/03 21:22 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - 10.6133/apjcn.202512_34(6).0012 [doi] PST - ppublish SO - Asia Pac J Clin Nutr. 2025 Dec;34(6):991-998. doi: 10.6133/apjcn.202512_34(6).0012. PMID- 41338692 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20260919 IS - 1938-3207 (Electronic) IS - 0002-9165 (Print) IS - 0002-9165 (Linking) VI - 122 IP - 6 DP - 2025 Dec TI - Development and validation of a brief Nutrition Security Screener (NSS) for clinical and public health settings. PG - 1689-1700 LID - S0002-9165(25)00513-1 [pii] LID - 10.1016/j.ajcnut.2025.08.017 [doi] AB - BACKGROUND: Nutrition security encompasses access, availability, and affordability of foods that support well-being and prevent and manage diet-related conditions. Although food security is widely studied, validated nutrition security measures are not yet widespread, highlighting a critical gap in clinical and public health research and practice. OBJECTIVES: This study aims to validate a brief Nutrition Security Screener (NSS) in the United States. METHODS: The NSS was refined in pilot studies and implemented in 5 diverse populations, totaling 20,523 adults. Two items assessed the presence and severity of nutrition insecurity (NI) and 13 corresponding barriers. Multivariable logistic regression models and pooled analyses examined distributions and associations of NI with food insecurity (FI), sociodemographic characteristics, and health. RESULTS: Across county, state, and national levels, NI prevalence ranged 18%-44% and varied by sociodemographic characteristics. About 60% of young adults reported NI, compared with 13% of older adults. NI was most prevalent among Hispanic/Latinx (26%-62%) compared with White (10%-40%) adults and those with the lowest (49%-65%) compared with the highest (3%-13%) income. NI only moderately correlated with FI measured by The Hunger Vital Sign (r = 0.55-0.63) and 6-item United States Department of Agriculture Module (r = 0.38-0.46), with discordance in 10%-28% of respondents. Adjusting for sociodemographic characteristics and FI, NI was independently associated with diabetes odds ratio (OR) = 1.46 [95% confidence interval (CI): 1.19, 1.79], obesity [OR = 1.42 (1.19, 1.70)], hypertension [OR = 1.34 (1.13, 1.59)], hypercholesterolemia [OR = 1.34 (1.11, 1.61)], heart disease [OR = 1.39 (1.05, 1.85)], and stroke [OR = 2.03 (1.08, 3.83)], but not cancer [OR = 0.98 (0.62, 1.54)]. Common barriers were expense (75%-81%), cultural or traditional foods being unhealthy (47%-75%), and limited access to healthy choices (47%-53%). Affirming more barriers was associated with higher odds of all health outcomes except cancer. CONCLUSIONS: A brief NSS enables assessment of NI prevalence and barriers to healthy eating in diverse populations, and is independently associated with diet-related disease, informing clinical, public health, and policy efforts to screen for and address NI. CI - Copyright (c) 2025 American Society for Nutrition. Published by Elsevier Inc. All rights reserved. FAU - Craig, Hope C AU - Craig HC AD - Food is Medicine Institute, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA. Electronic address: hope.craig@tufts.edu. FAU - Sharib, Julia Reedy AU - Sharib JR AD - Food is Medicine Institute, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA. FAU - Ridberg, Ronit AU - Ridberg R AD - Food is Medicine Institute, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA. FAU - Caldwell, Julia AU - Caldwell J AD - Los Angeles County Department of Public Health, Los Angeles, CA, USA. FAU - Shah-Patel, Dipa AU - Shah-Patel D AD - Los Angeles County Department of Public Health, Los Angeles, CA, USA. FAU - Warner, Kelly AU - Warner K AD - Los Angeles County Department of Public Health, Los Angeles, CA, USA. FAU - de la Haye, Kayla AU - de la Haye K AD - Center for Economic and Social Research, University of Southern California, Los Angeles, CA, USA. FAU - Livings, Michelle AU - Livings M AD - Department of Health Sciences, Rutgers University-Camden, Camden, NJ, USA. FAU - Brown, Meagan C AU - Brown MC AD - Kaiser Permanente Washington Health Research Unit, Seattle, WA, USA. FAU - Chao, Ceping AU - Chao C AD - Kaiser Permanente, Los Angeles, CA, USA. FAU - Habib, Mina AU - Habib M AD - Kaiser Permanente, Los Angeles, CA, USA. FAU - Cushing-Haugen, Kara AU - Cushing-Haugen K AD - Kaiser Permanente Washington Health Research Unit, Seattle, WA, USA. FAU - Nau, Claudia AU - Nau C AD - Kaiser Permanente, Los Angeles, CA, USA. FAU - Schwartz, Pamela AU - Schwartz P AD - Kaiser Permanente, Los Angeles, CA, USA. FAU - Mozaffarian, Dariush AU - Mozaffarian D AD - Food is Medicine Institute, Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA, USA; Division of Cardiology, Tufts Medical Center, and Tufts University School of Medicine, Boston, MA, USA. LA - eng GR - R01 HL115189/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Validation Study DEP - 20251020 PL - United States TA - Am J Clin Nutr JT - The American journal of clinical nutrition JID - 0376027 SB - IM MH - Humans MH - Adult MH - Male MH - Female MH - Middle Aged MH - United States MH - *Food Insecurity MH - *Public Health MH - Aged MH - Young Adult MH - Adolescent MH - *Food Security MH - *Food Supply MH - Nutritional Status PMC - PMC12676013 MID - NIHMS2112458 OTO - NOTNLM OT - diet-related disease OT - food is medicine OT - food security OT - nutrition security OT - screening tools COIS- Conflict of interest Meagan C. Brown, Ceping Chao, Mina Habib, Kara Cushing-Haugen, Claudia Nau, and Pamela Schwartz are affiliates of Kaiser Permanente, which supported the National Social Health Survey and the Food is Medicine Surveys. All other authors report no conflicts of interest. EDAT- 2025/12/04 02:11 MHDA- 2025/12/04 02:12 PMCR- 2026/07/17 CRDT- 2025/12/03 20:54 PHST- 2025/02/25 00:00 [received] PHST- 2025/08/19 00:00 [revised] PHST- 2025/08/25 00:00 [accepted] PHST- 2025/12/04 02:12 [medline] PHST- 2025/12/04 02:11 [pubmed] PHST- 2025/12/03 20:54 [entrez] PHST- 2026/07/17 00:00 [pmc-release] AID - S0002-9165(25)00513-1 [pii] AID - 10.1016/j.ajcnut.2025.08.017 [doi] PST - ppublish SO - Am J Clin Nutr. 2025 Dec;122(6):1689-1700. doi: 10.1016/j.ajcnut.2025.08.017. Epub 2025 Oct 20. PMID- 41338691 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20251222 IS - 1938-3207 (Electronic) IS - 0002-9165 (Linking) VI - 122 IP - 6 DP - 2025 Dec TI - Optimal anthropometric discharge criteria from treatment of wasting: meta-analysis of individual patient data from 34 studies. PG - 1658-1668 LID - S0002-9165(25)00526-X [pii] LID - 10.1016/j.ajcnut.2025.09.010 [doi] AB - BACKGROUND: Community-based treatment of acute malnutrition saves lives, but recovered children remain at risk of relapse postdischarge. Strategies to reduce this risk may include modification of anthropometric discharge criteria. OBJECTIVES: This study aims to compare the diagnostic accuracy of anthropometric indices to reduce postdischarge relapse risk. METHODS: We searched PubMed from inception to June 2022. We included studies that enrolled children aged 0-59 mo successfully treated for severe or moderate acute malnutrition (SAM or MAM), assessed anthropometry at discharge, and had >/=1 follow-up assessment /=0.75. Primary outcomes were SAM relapse (SAM episode after successful SAM treatment: weight-for-height Z-score (WHZ) < -3, mid-upper arm circumference (MUAC) < 11.5 cm and/or edema) and MAM relapse (MAM episode after successful MAM treatment: -3 0.6. In terms of convergent validity, the CFSQ and its subscales were moderately to highly correlated with the PHQ-9 (r=0.73 for total score, p<0.05) and the GAD-7 (r=0.66 for total score, p<0.05) and moderately correlated with quality of life as measured by the Cystic Fibrosis Questionnaire Revised (CFQ-R) Social (r=-0.59 for total score, p<0.05) and Treatment Burden subscales (r=-0.63 for total score, p<0.05). Subscales of the CFSQ were moderately correlated with the CFQ-R Emotional or Physical Functioning subscales, and weakly correlated with forced expiratory volume in 1 s per cent predicted or body mass index. CONCLUSIONS: The CFSQ is a valid and reliable measure in terms of internal consistency and convergent validity with existing measures of mental health and quality of life commonly used in CF care and research. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Snell, Carolyn J AU - Snell CJ AUID- ORCID: 0000-0002-6292-2516 AD - Pulmonary Medicine, Boston Children's Hospital, Boston, Massachusetts, USA carolyn.snell@childrens.harvard.edu. AD - Harvard Medical School, Boston, Massachusetts, USA. FAU - Ryan, Morgan E AU - Ryan ME AD - Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Bailey, Isabel V AU - Bailey IV AD - Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Sandage, Danielle AU - Sandage D AD - Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Ertman, Benjamin AU - Ertman B AD - Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Dahlberg, Suzanne AU - Dahlberg S AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Alpern, Adrianne N AU - Alpern AN AD - Children's Hospital of Orange County, Orange, California, USA. FAU - Smith, Beth AU - Smith B AD - Division of Child and Adolescent Psychiatry, State University of New York, Buffalo, New York, USA. FAU - Garcia, Bryan AU - Garcia B AD - Department of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama, USA. FAU - Ito, Ethan AU - Ito E AD - Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Sawicki, Gregory AU - Sawicki G AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Boston Children's Hospital, Boston, Massachusetts, USA. FAU - Uluer, Ahmet AU - Uluer A AD - Harvard Medical School, Boston, Massachusetts, USA. AD - Boston Children's Hospital, Boston, Massachusetts, USA. LA - eng PT - Journal Article PT - Multicenter Study PT - Validation Study DEP - 20251203 PL - England TA - BMJ Open Respir Res JT - BMJ open respiratory research JID - 101638061 SB - IM MH - Humans MH - *Cystic Fibrosis/psychology/complications MH - Male MH - Female MH - Adult MH - Reproducibility of Results MH - *Stress, Psychological/diagnosis/etiology MH - Middle Aged MH - Surveys and Questionnaires MH - Young Adult MH - Psychometrics MH - *Depression/diagnosis MH - *Anxiety/diagnosis MH - Adolescent MH - Quality of Life MH - Patient Health Questionnaire PMC - PMC12682168 OTO - NOTNLM OT - Cystic Fibrosis OT - Psychology OT - Surveys and Questionnaires COIS- Competing interests: None declared. EDAT- 2025/12/04 02:11 MHDA- 2025/12/04 02:12 PMCR- 2025/12/03 CRDT- 2025/12/03 20:32 PHST- 2025/04/07 00:00 [received] PHST- 2025/11/01 00:00 [accepted] PHST- 2025/12/04 02:12 [medline] PHST- 2025/12/04 02:11 [pubmed] PHST- 2025/12/03 20:32 [entrez] PHST- 2025/12/03 00:00 [pmc-release] AID - 12/1/e003322 [pii] AID - bmjresp-2025-003322 [pii] AID - 10.1136/bmjresp-2025-003322 [doi] PST - epublish SO - BMJ Open Respir Res. 2025 Dec 3;12(1):e003322. doi: 10.1136/bmjresp-2025-003322. PMID- 41337620 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20251203 IS - 1678-4561 (Electronic) IS - 1413-8123 (Linking) VI - 30 IP - 11 DP - 2025 Nov TI - Social validity of comprehensive sexuality education effects in the suburbs of the Federal District, Brazil: a case study. PG - e11522025 LID - S1413-81232025001100315 [pii] LID - 10.1590/1413-812320253011.11522025 [doi] AB - Comprehensive sexuality education is an effective strategy to promote adolescents' sexual and reproductive health and exercise citizenship. This paper presents the social validity of the effects of intervention research, through multiple case studies, with students and teachers, in two public schools in the Federal District. Participatory workshops were used to address self-esteem, gender identity, sexual orientation, support networks, contraceptive methods, youth participation, and violence. We generated data through reports and evaluations of each workshop, field diaries, photographic records, and final evaluation questionnaires with teachers and students. The results indicate that the study could: i) expose the context of structural vulnerability in the cases studied; ii) promote new behaviors and ways of thinking; iii) facilitate learning and the development of skills for health and well-being. The findings endorse the intervention's high social validity of the effects, showing its ability to effect change for teachers and students, including improving their relationship. The observed tensions confirm the importance of teacher training and the urgency of support initiatives that can overcome the political and ideological challenges of the issue. FAU - Anderle, Patricia de Souza Rezende AU - Anderle PSR AUID- ORCID: 0000-0001-7146-6711 AD - Faculdade de Ciencias e Tecnologias em Saude, Universidade de Brasilia. Centro Metropolitano, Ceilandia Sul. Brasilia DF Brasil. psrezende@unb.br. FAU - Rocha, Dais Goncalves AU - Rocha DG AUID- ORCID: 0000-0003-1103-5930 AD - Departamento de Saude Coletiva, Faculdade de Saude, Universidade de Brasilia. Brasilia DF Brasil. FAU - Oliveira, Flavia Mazitelli de AU - Oliveira FM AUID- ORCID: 0000-0001-5060-592X AD - Faculdade de Ciencias e Tecnologias em Saude, Universidade de Brasilia. Centro Metropolitano, Ceilandia Sul. Brasilia DF Brasil. psrezende@unb.br. FAU - Freitas, Sandra Carvalho Cavalcante AU - Freitas SCC AUID- ORCID: 0000-0002-5565-7849 AD - Secretaria de Estado de Educacao do Distrito Federal. Brasilia DF Brasil. FAU - Santos, Victor Hugo de Lima AU - Santos VHL AUID- ORCID: 0000-0002-5192-2350 AD - Instituto de Psicologia, Universidade de Brasilia. Brasilia DF Brasil. FAU - Oliveira, Barbara Gripp de AU - Oliveira BG AUID- ORCID: 0009-0006-8606-1278 AD - Faculdade de Ciencias e Tecnologias em Saude, Universidade de Brasilia. Centro Metropolitano, Ceilandia Sul. Brasilia DF Brasil. psrezende@unb.br. FAU - Murta, Sheila Giardini AU - Murta SG AUID- ORCID: 0000-0001-5515-5219 AD - Departamento de Psicologia Clinica, Instituto de Psicologia, Universidade de Brasilia. Brasilia DF Brasil. LA - por LA - eng PT - Journal Article TT - Validade social de efeitos da educacao integral em sexualidade na periferia do Distrito Federal, Brasil: estudo de casos. DEP - 20250621 PL - Brazil TA - Cien Saude Colet JT - Ciencia & saude coletiva JID - 9713483 SB - IM MH - Brazil MH - Humans MH - *Sex Education/methods MH - Adolescent MH - Female MH - Male MH - Students/statistics & numerical data MH - Surveys and Questionnaires MH - School Teachers MH - Self Concept MH - Sexual Behavior MH - Reproductive Health MH - Schools EDAT- 2025/12/03 19:14 MHDA- 2025/12/03 19:15 CRDT- 2025/12/03 14:04 PHST- 2024/07/05 00:00 [received] PHST- 2025/06/19 00:00 [accepted] PHST- 2025/12/03 19:15 [medline] PHST- 2025/12/03 19:14 [pubmed] PHST- 2025/12/03 14:04 [entrez] AID - S1413-81232025001100315 [pii] AID - 10.1590/1413-812320253011.11522025 [doi] PST - ppublish SO - Cien Saude Colet. 2025 Nov;30(11):e11522025. doi: 10.1590/1413-812320253011.11522025. Epub 2025 Jun 21. PMID- 41337388 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20251203 IS - 2694-0604 (Electronic) IS - 2375-7477 (Linking) VI - 2025 DP - 2025 Jul TI - Tracking Limb Movement in Preterm Infants Using an Inertial Measurement Bracelet. PG - 1-7 LID - 10.1109/EMBC58623.2025.11252707 [doi] AB - Preterm infants are monitored continuously in the neonatal intensive care unit (NICU), often for weeks to months. Cardiac and respiratory signals are routinely collected to enable detection and early interventions that mitigate a wide range of complications associated with prematurity. Neurological monitoring is often lacking in the NICU despite the high risk of neurological sequelae including motor and cognitive disorders. Here we report our design and implementation of a wireless wearable device for quantifying limb movements of preterm infants. The Limb Inertial Measurement Bracelet for Infant Tracking (LIMBIT) is a thin, flexible, 3-gram bracelet placed around the infants' wrists and ankles for continuous measurement of limb motion. Three-dimensional acceleration and angular velocity are recorded using the device's inertial measurement unit (IMU). Ultra-low battery consumption is achieved through an embedded system architecture with a power-saving algorithm for optimal interplay between the accelerometer and gyroscope sensors. With a battery life of several days, we demonstrate the feasibility of accurate longitudinal and continuous recordings in the NICU. Movement signals are synchronized with other routinely collected health signals. The device's size, weight, flexibility, and integration within soft, sterile materials allows for a safe and non-invasive recording method in the NICU. LIMBITs enable the study of movement as a physiological vital sign and, like other vital signs, may enable more accurate detection and forecasting of adverse events as well as improved motor and cognitive outcomes in preterm infants. FAU - Kalhoro, Imran AU - Kalhoro I FAU - Blodgett, Leonora AU - Blodgett L FAU - Jafari, Roozbeh AU - Jafari R FAU - Sternad, Dagmar AU - Sternad D FAU - Paydarfar, David AU - Paydarfar D LA - eng PT - Journal Article PL - United States TA - Annu Int Conf IEEE Eng Med Biol Soc JT - Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference JID - 101763872 SB - IM MH - Humans MH - *Infant, Premature/physiology MH - Infant, Newborn MH - Movement/physiology MH - *Extremities/physiology MH - *Wearable Electronic Devices MH - Monitoring, Physiologic/instrumentation MH - Intensive Care Units, Neonatal MH - Equipment Design MH - Algorithms EDAT- 2025/12/03 19:14 MHDA- 2025/12/03 19:15 CRDT- 2025/12/03 13:51 PHST- 2025/12/03 19:15 [medline] PHST- 2025/12/03 19:14 [pubmed] PHST- 2025/12/03 13:51 [entrez] AID - 10.1109/EMBC58623.2025.11252707 [doi] PST - ppublish SO - Annu Int Conf IEEE Eng Med Biol Soc. 2025 Jul;2025:1-7. doi: 10.1109/EMBC58623.2025.11252707. PMID- 41336603 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20251203 IS - 2694-0604 (Electronic) IS - 2375-7477 (Linking) VI - 2025 DP - 2025 Jul TI - Can Gait Deviations Be Identified through Video-Based Gait Analysis? Validation of the BlazePose Pose Estimation Algorithm. PG - 1-5 LID - 10.1109/EMBC58623.2025.11254531 [doi] AB - Accurate identification of gait deviations is critical for effective intervention in children with cerebral palsy (CP). However, traditional marker-based gait analysis systems, while highly precise, are costly and impractical for broad clinical applications. Video-based pose estimation algorithms (PEAs) such as BlazePose offer a potential alternative, leveraging standard video inputs to provide scalable and accessible gait assessment. This study assessed the validity of BlazePose in diagnosing gait deviations and analyzing joint kinematics in children with CP, using marker-based motion capture as the gold standard and comparing the diagnostic results with observational gait analysis (OGA). Confusion matrices, root mean square error (RMSE), and correlation analyses were used to assess diagnostic accuracy and joint angle validity. BlazePose achieved higher accuracy and precision but lower recall and F1 scores than the traditional observational gait analysis in diagnosing gait deviations. Additionally, the joint angle errors exceed 5 degrees . While limitations remain, BlazePose has potential to be used for gait screening and remote monitoring, particularly in resource-limited situations.Clinical Relevance-This study demonstrates the clinical relevance of BlazePose as a cost-effective, accessible tool for gait analysis in children with cerebral palsy, particularly in resource-limited settings. By offering scalable and objective gait deviation diagnosis, it supports early detection and intervention, complementing traditional marker-based systems for broader clinical application. FAU - Gao, Xi AU - Gao X FAU - Cheng, Xingye AU - Cheng X FAU - Jiao, Yiran AU - Jiao Y FAU - Reading, Stacey AU - Reading S FAU - Zhang, Yanxin AU - Zhang Y LA - eng PT - Journal Article PT - Validation Study PL - United States TA - Annu Int Conf IEEE Eng Med Biol Soc JT - Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference JID - 101763872 SB - IM MH - Humans MH - *Algorithms MH - *Video Recording MH - Cerebral Palsy/physiopathology/diagnosis MH - Child MH - *Gait Analysis/methods MH - Biomechanical Phenomena MH - *Gait MH - Male MH - Female MH - Reproducibility of Results EDAT- 2025/12/03 19:14 MHDA- 2025/12/03 19:15 CRDT- 2025/12/03 13:47 PHST- 2025/12/03 19:15 [medline] PHST- 2025/12/03 19:14 [pubmed] PHST- 2025/12/03 13:47 [entrez] AID - 10.1109/EMBC58623.2025.11254531 [doi] PST - ppublish SO - Annu Int Conf IEEE Eng Med Biol Soc. 2025 Jul;2025:1-5. doi: 10.1109/EMBC58623.2025.11254531. PMID- 41336450 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20251203 IS - 2694-0604 (Electronic) IS - 2375-7477 (Linking) VI - 2025 DP - 2025 Jul TI - Predicting Skeletal Landmarks from Soft-Tissue Landmarks Using Machine Learning: A Study on Nasion Localization. PG - 1-5 LID - 10.1109/EMBC58623.2025.11251704 [doi] AB - Cephalometric analysis plays a crucial role in orthodontics and maxillofacial surgery, traditionally relying on X-ray imaging to assess skeletal structures. However, reduced Field of View (FOV) CBCT scans, which minimize radiation exposure, often exclude key reference points such as the skeletal nasion. This study investigates the feasibility of predicting the nasion position using machine learning (ML) models based on soft-tissue landmarks. A dataset of 137 CBCT scans was analyzed, with the Sellion, Tragus (left and right), and Alare (left and right) landmarks used as predictors. Three ML models-Linear Regression, Random Forest, and Feedforward Neural Network (FFNN)-were evaluated through 10-fold cross-validation. The Linear Regression model demonstrated the highest accuracy, achieving a mean Euclidean error of 1.452 +/- 1.077 mm between predicted and ground truth landmarks. These findings suggest that ML models can reliably estimate skeletal landmarks from soft-tissue features, introducing the possibility to evaluate a less-invasive alternative for cephalometric analysis. This approach has the potential to reduce reliance on full-cranium CBCT scans, thereby lowering patient radiation exposure while maintaining diagnostic accuracy.Clinical Relevance- The use of ML to predict skeletal landmarks from soft-tissue references offers a radiation-minimizing alternative for cephalometric analysis. By integrating reduced-FOV CBCT with facial scan data, clinicians can accurately estimate the nasion position without requiring full-cranium imaging. This approach can enhance orthodontic and surgical planning, particularly in pediatric and radiation-sensitive patients. Further development of AI-driven landmark prediction may lead to broader applications in non-invasive craniofacial diagnostics, improving patient safety and accessibility to cephalometric analysis. FAU - Baldini, B AU - Baldini B FAU - Yazdi, A Shadman AU - Yazdi AS FAU - Serafin, M AU - Serafin M FAU - Tartaglia, G M AU - Tartaglia GM FAU - Baselli, G AU - Baselli G LA - eng PT - Journal Article PL - United States TA - Annu Int Conf IEEE Eng Med Biol Soc JT - Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference JID - 101763872 SB - IM MH - Humans MH - *Machine Learning MH - *Cephalometry/methods MH - *Anatomic Landmarks/diagnostic imaging MH - Cone-Beam Computed Tomography MH - Neural Networks, Computer MH - Female MH - Male MH - Image Processing, Computer-Assisted/methods MH - Adult MH - Linear Models MH - Adolescent EDAT- 2025/12/03 19:14 MHDA- 2025/12/03 19:15 CRDT- 2025/12/03 13:46 PHST- 2025/12/03 19:15 [medline] PHST- 2025/12/03 19:14 [pubmed] PHST- 2025/12/03 13:46 [entrez] AID - 10.1109/EMBC58623.2025.11251704 [doi] PST - ppublish SO - Annu Int Conf IEEE Eng Med Biol Soc. 2025 Jul;2025:1-5. doi: 10.1109/EMBC58623.2025.11251704. PMID- 41335793 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20251203 IS - 2694-0604 (Electronic) IS - 2375-7477 (Linking) VI - 2025 DP - 2025 Jul TI - Addressing Occlusions and Pose Challenges in Clinical Gait Analysis: A Robust 3D-to-2D Motion Pipeline. PG - 1-7 LID - 10.1109/EMBC58623.2025.11254493 [doi] AB - Cerebral palsy (CP), one of the most common causes of physical disability in childhood, affects movement, balance and posture due to atypical brain development or damage to motor control areas. Clinical gait analysis (CGA) is essential for the diagnosis, treatment planning and management of CP, and motion capture systems are an important tool for assessing movement patterns. Markerless motion capture systems using computer vision and machine learning algorithms offer several advantages over traditional marker-based methods, including improved patient comfort, mobility and reduced set-up time. However, these systems face challenges, such as pose ambiguities in multi-person images and occlusions, which can reduce the accuracy of kinematic data in clinical applications.In this paper, we present a workflow that addresses these challenges by leveraging machine learning and computer vision techniques to improve the reliability and accuracy of markerless motion capture in clinical gait analysis (CGA). Specifically, our approach utilizes the projection of three-dimensional (3D) onto two-dimensional (2D) points to map the original 3D motion capture points onto the video plane and track the subject using distance-based metrics. Additionally, we integrate multiple data modalities to improve robustness. The proposed workflow enables detailed comparisons between markerless and marker-based systems. By improving the performance and applicability of markerless motion capture, this study contributes to a more accessible and effective clinical assessment of children with CP. FAU - Homlong, Eirik G AU - Homlong EG FAU - Quadir, Hemin A AU - Quadir HA FAU - Kumar, Rahul P AU - Kumar RP FAU - Elle, Ole Jakob AU - Elle OJ FAU - Wiig, Ola AU - Wiig O LA - eng PT - Journal Article PL - United States TA - Annu Int Conf IEEE Eng Med Biol Soc JT - Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference JID - 101763872 SB - IM MH - Humans MH - *Gait Analysis/methods MH - *Imaging, Three-Dimensional/methods MH - Cerebral Palsy/physiopathology MH - Algorithms MH - Machine Learning MH - Motion MH - Biomechanical Phenomena MH - *Gait MH - Reproducibility of Results EDAT- 2025/12/03 19:14 MHDA- 2025/12/03 19:15 CRDT- 2025/12/03 13:43 PHST- 2025/12/03 19:15 [medline] PHST- 2025/12/03 19:14 [pubmed] PHST- 2025/12/03 13:43 [entrez] AID - 10.1109/EMBC58623.2025.11254493 [doi] PST - ppublish SO - Annu Int Conf IEEE Eng Med Biol Soc. 2025 Jul;2025:1-7. doi: 10.1109/EMBC58623.2025.11254493. PMID- 41335734 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20251203 IS - 2694-0604 (Electronic) IS - 2375-7477 (Linking) VI - 2025 DP - 2025 Jul TI - A Wearable System for Evaluation of PSSE Compliance for AIS Patient. PG - 1-4 LID - 10.1109/EMBC58623.2025.11254910 [doi] AB - For adolescent idiopathic scoliosis (AIS), a common condition in children, physiotherapy scoliosis-specific exercise (PSSE) is an effective conservative treatment. However, the long-term process of PSSE treatment often leads to low compliance during unsupervised exercises. In this study, we proposed a wearable system for the evaluation of PSSE compliance for AIS patients. The proposed system contains wearable devices and analysis software. The wearable device collected surface electromyography (sEMG) data from back muscles. We extracted features from sEMG data, and adopted support vector machine classifiers to evaluate PSSE compliance for AIS patients in the software. To validate the proposed system, we collected data from 11 AIS patients during a typical exercise in PSSE. Among the extracted features, the most promising for differentiating PSSE compliance were those related to electromyography (EMG) amplitude and muscle fatigue. Specifically, the integrated EMG and frequency ratio showed strong potential. To evaluate the proposed system, we adopted leave-one-subject-out cross-validation, resulting in perfect accuracy. The results showed that the proposed system was potentially feasible for evaluating PSSE compliance in AIS patients to achieve optimal efficacy, and was convenient for supporting clinicians and parents in monitoring correction of AIS patients' PSSE execution.Clinical Relevance- This system provides a method for evaluating PSSE compliance in AIS patients, helping achieve optimal PSSE efficacy. FAU - Huang, Yongcong AU - Huang Y FAU - Li, Junjie AU - Li J FAU - Zhu, Huaiyu AU - Zhu H FAU - Yu, Bohan AU - Yu B FAU - Yu, Bihong AU - Yu B FAU - Du, Honggen AU - Du H FAU - Chen, Shao AU - Chen S FAU - Chen, Xiaomin AU - Chen X FAU - Liu, Chen AU - Liu C FAU - Wang, Kaiqi AU - Wang K FAU - Dong, Junxiang AU - Dong J FAU - Mou, Jiahao AU - Mou J FAU - Pan, Yun AU - Pan Y LA - eng PT - Journal Article PL - United States TA - Annu Int Conf IEEE Eng Med Biol Soc JT - Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference JID - 101763872 SB - IM MH - Humans MH - *Scoliosis/physiopathology/therapy/rehabilitation MH - *Wearable Electronic Devices MH - Electromyography/instrumentation MH - *Patient Compliance MH - Adolescent MH - Female MH - *Exercise Therapy/instrumentation MH - Support Vector Machine MH - Male MH - Child EDAT- 2025/12/03 19:14 MHDA- 2025/12/03 19:15 CRDT- 2025/12/03 13:43 PHST- 2025/12/03 19:15 [medline] PHST- 2025/12/03 19:14 [pubmed] PHST- 2025/12/03 13:43 [entrez] AID - 10.1109/EMBC58623.2025.11254910 [doi] PST - ppublish SO - Annu Int Conf IEEE Eng Med Biol Soc. 2025 Jul;2025:1-4. doi: 10.1109/EMBC58623.2025.11254910. PMID- 41335700 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20251203 IS - 2694-0604 (Electronic) IS - 2375-7477 (Linking) VI - 2025 DP - 2025 Jul TI - Gaussian Process-driven Hidden Markov Models for Early Diagnosis of Infant Gait Anomalies. PG - 1-7 LID - 10.1109/EMBC58623.2025.11254881 [doi] AB - Gait analysis is critical in the early detection and intervention of motor neurological disorders in infants. Despite its importance, traditional methods often struggle to model the high variability and rapid developmental changes inherent to infant gait. To address these challenges, we propose a probabilistic Gaussian Process (GP)-driven Hidden Markov Model (HMM) to capture the complex temporal dynamics of infant gait cycles and enable automatic recognition of gait anomalies. We use a Multi-Output GP (MoGP) framework to model interdependencies between multiple gait signals, with a composite kernel designed to account for smooth, non-smooth, and periodic behaviors exhibited in gait cycles. The HMM segments gait phases into normal and abnormal states, facilitating the precise identification of pathological movement patterns in stance and swing phases. The proposed model is trained and assessed using a dataset of infants with and without motor neurological disorders via leave-one-subject-out cross-validation. Results demonstrate that the MoGP outperforms Long Short-Term Memory (LSTM) based neural networks in modeling gait dynamics, offering improved accuracy, variance explanation, and temporal alignment. Further, the predictive performance of MoGP provides a principled framework for uncertainty quantification, allowing confidence estimation in gait trajectory predictions. Additionally, the HMM enhances interpretability by explicitly modeling gait phase transitions, improving the detection of subtle anomalies across multiple gait cycles. These findings highlight the MoGP-HMM framework as a robust automatic gait analysis tool showing better performance metrics compared with deep learning approaches, allowing early diagnosis and intervention strategies for infants with neurological motor disorders. FAU - Torres-Torres, Luis F AU - Torres-Torres LF FAU - Arias-Garcia, Jonatan AU - Arias-Garcia J FAU - Garcia, Hernan F AU - Garcia HF FAU - Lopez-Lopera, Andres F AU - Lopez-Lopera AF FAU - Vargas-Bonilla, Jesus F AU - Vargas-Bonilla JF LA - eng PT - Journal Article PL - United States TA - Annu Int Conf IEEE Eng Med Biol Soc JT - Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference JID - 101763872 SB - IM MH - Humans MH - *Markov Chains MH - Infant MH - Normal Distribution MH - Early Diagnosis MH - *Gait MH - Neural Networks, Computer MH - Algorithms MH - *Gait Analysis/methods MH - Hidden Markov Models EDAT- 2025/12/03 19:14 MHDA- 2025/12/03 19:15 CRDT- 2025/12/03 13:43 PHST- 2025/12/03 19:15 [medline] PHST- 2025/12/03 19:14 [pubmed] PHST- 2025/12/03 13:43 [entrez] AID - 10.1109/EMBC58623.2025.11254881 [doi] PST - ppublish SO - Annu Int Conf IEEE Eng Med Biol Soc. 2025 Jul;2025:1-7. doi: 10.1109/EMBC58623.2025.11254881. PMID- 41334886 OWN - NLM STAT- MEDLINE DCOM- 20260903 LR - 20260904 IS - 2047-945X (Electronic) IS - 0260-1060 (Linking) VI - 32 IP - 5 DP - 2026 Sep TI - Cross-sectional study of taste perception and related factors for healthy eating habits among Japanese schoolchildren. PG - 1703-1712 LID - 10.1177/02601060251399253 [doi] AB - Background: Taste perception plays an important role in a person's food preferences. Promoting an interest in taste and developing taste perception are important factors for healthy eating habits. However, only a few studies have been conducted to investigate the association of taste perception with personal background factors, nutrition, and eating habits. Aim: To investigate the current status and associated factors of taste perception among primary school children in Japan through a cross-sectional study design. Methods: A total of 77 children aged 9-11 years participated in this study between July and August 2022. Taste perception was assessed using the validated "Taste Strips" test, and participants were classified as either having high taste perception if their total taste score was >/=9 or having low taste perception if their score was <9. Data on demographic characteristics, anthropometric measurements, eating habits, nutrient intake, and self-efficacy were collected through questionnaires and regular health checkups. Results: Among the participants, 20% were classified as having low taste perception. Multivariable logistic regression analysis showed that family commensality at dinner (adjusted odds ratio: 5.4, 95% confidence interval: 1.1-28.0) and having a positive attitude (adjusted odds ratio: 1.1, 95% confidence interval: 1.0-1.1) were significantly associated with children's taste perception. Conclusion: Our findings underscore the importance of nutrition education and the home environment in supporting the development of taste perception, potentially guiding interventions to promote healthy eating habits during children's critical formative period. FAU - Ando, Hitomi AU - Ando H AUID- ORCID: 0000-0002-4564-4083 AD - College of Nursing Art and Science, University of Hyogo, Akashi, Hyogo, Japan. RINGGOLD: 12743 AD - Division of Health Sciences, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan. FAU - Kinouchi, Kaori AU - Kinouchi K AUID- ORCID: 0000-0001-9110-9770 AD - Division of Health Sciences, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan. FAU - Watanabe, Hiroko AU - Watanabe H AUID- ORCID: 0000-0001-6700-627X AD - Division of Health Sciences, Graduate School of Medicine, The University of Osaka, Suita, Osaka, Japan. LA - eng PT - Journal Article DEP - 20251203 PL - England TA - Nutr Health JT - Nutrition and health JID - 8306569 RN - Japanese people SB - IM MH - Humans MH - Child MH - Cross-Sectional Studies MH - Female MH - Male MH - Japan MH - *Feeding Behavior/psychology MH - *Taste Perception MH - Food Preferences/psychology MH - *Diet, Healthy/psychology MH - Surveys and Questionnaires MH - East Asian People OTO - NOTNLM OT - Taste perception OT - eating habits OT - health education OT - self-efficacy OT - taste test COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. Data availabilityData will be made available on request. EDAT- 2025/12/03 14:12 MHDA- 2026/09/03 17:36 CRDT- 2025/12/03 08:52 PHST- 2026/09/03 17:36 [medline] PHST- 2025/12/03 14:12 [pubmed] PHST- 2025/12/03 08:52 [entrez] AID - 10.1177/02601060251399253 [doi] PST - ppublish SO - Nutr Health. 2026 Sep;32(5):1703-1712. doi: 10.1177/02601060251399253. Epub 2025 Dec 3. PMID- 41332253 OWN - NLM STAT- MEDLINE DCOM- 20251203 LR - 20251206 IS - 1550-2783 (Electronic) IS - 1550-2783 (Linking) VI - 22 IP - 1 DP - 2025 Dec 31 TI - Prevalence of physically active females at risk for the female athlete triad in Spain. PG - 2590641 LID - 10.1080/15502783.2025.2590641 [doi] LID - 2590641 AB - BACKGROUND: The female athlete triad (Triad) refers to the interrelationship between energy availability, menstrual function, and bone health, which may have clinical and subclinical manifestations including eating disorders, functional hypothalamic amenorrhea, and osteoporosis. The aim of this study was to analyze the prevalence of physically active 15- to 45-year-old Spanish women at risk for the Triad. METHODS: A descriptive cross-sectional study was carried out using the validated questionnaires 'Low Energy Availability in Females Questionnaire' (LEAF-Q) and the 'Female Athlete Screening Tool' (FAST). Exercising women were invited to participate anonymously and voluntarily by email via Spanish sports clubs and federations, as well as through social networks. The questionnaires were also distributed to elite athletes attending the High Performance Center of Sant Cugat del Valles (Barcelona). RESULTS: The study participants comprised 1154 physically active women (age = 28.5 +/- 7.7 years; height = 165.2 +/- 6.2 cm; body weight = 60.5 +/- 9.7), representing 78 recreational and competitive level sports. The results showed that 40.0% (n = 462) were considered at risk for the Triad, while 24.3% (n = 280) were at risk for subclinical eating disorder, and 7.3% (n = 84) at risk for clinical eating disorder. Other results were: menstrual dysfunction displayed a positive correlation with the LEAF-Q score (r = 0.499, p = < 0.001); FAST presented an association with the LEAF-Q score (r = 0.252, p < 0.001); and body weight (r = 0.207, p = < 0.001) and body mass index (r = 0.225, p = < 0.001) displayed a positive correlation with the FAST score. CONCLUSION: Based on this research, the implementation of strategies for the prevention, diagnosis and treatment of the Triad disorders should be made a priority among physically active Spanish women. FAU - Torres Dos Ramos, Ana AU - Torres Dos Ramos A AUID- ORCID: 0009-0007-6104-9632 AD - Faculty of Health Sciences, Universitat Oberta de Catalunya, Barcelona, Spain. FAU - Bellver, Montse AU - Bellver M AUID- ORCID: 0000-0002-3081-0165 AD - Centro de Alto Rendimiento (CAR), Sant Cugat del Valles, Barcelona, Spain. AD - Consorcio Sanitario de Terrassa, Terrassa, Spain. FAU - Esquius, Laura AU - Esquius L AUID- ORCID: 0000-0002-1009-5379 AD - Epi4health Research Group, Faculty of Health Sciences, Universitat Oberta de Catalunya, Barcelona, Spain. FAU - Martinez Pastor, Ivan AU - Martinez Pastor I AUID- ORCID: 0009-0008-6298-6158 AD - Gesein, S.L., Madrid, Spain. FAU - Barea Montes, Antonia AU - Barea Montes A AD - Centro de Alto Rendimiento (CAR), Sant Cugat del Valles, Barcelona, Spain. AD - Consorcio Sanitario de Terrassa, Terrassa, Spain. FAU - Andres, Ana AU - Andres A AUID- ORCID: 0000-0002-6488-1658 AD - Faculty of Psychology, Education and Sport Sciences Blanquerna, Ramon Llull University, Barcelona, Spain. LA - eng PT - Journal Article DEP - 20251202 PL - United States TA - J Int Soc Sports Nutr JT - Journal of the International Society of Sports Nutrition JID - 101234168 SB - IM MH - Humans MH - Female MH - Spain/epidemiology MH - Cross-Sectional Studies MH - *Female Athlete Triad Syndrome/epidemiology MH - Prevalence MH - Adult MH - Young Adult MH - Adolescent MH - Middle Aged MH - *Exercise MH - Surveys and Questionnaires MH - Feeding and Eating Disorders/epidemiology MH - Risk Factors MH - Athletes PMC - PMC12677033 OTO - NOTNLM OT - Amenorrhea OT - disordered eating OT - energy deficiency OT - menstrual cycle OT - women in sport COIS- None. No potential conflict of interest was reported by the authors. EDAT- 2025/12/03 07:40 MHDA- 2025/12/03 07:41 PMCR- 2025/12/02 CRDT- 2025/12/03 03:03 PHST- 2025/12/03 07:41 [medline] PHST- 2025/12/03 07:40 [pubmed] PHST- 2025/12/03 03:03 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - 2590641 [pii] AID - 10.1080/15502783.2025.2590641 [doi] PST - ppublish SO - J Int Soc Sports Nutr. 2025 Dec 31;22(1):2590641. doi: 10.1080/15502783.2025.2590641. Epub 2025 Dec 2. PMID- 41331935 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260626 LR - 20260626 IS - 0778-7367 (Print) IS - 2049-3258 (Electronic) IS - 0778-7367 (Linking) VI - 84 IP - 1 DP - 2025 Dec 2 TI - Does the physical activity-adolescent mental health model generalize across different social environments? PG - 4 LID - 10.1186/s13690-025-01806-x [doi] LID - 4 AB - BACKGROUND: Insufficient physical activity, high prevalence of psychological problems, and inadequate sleep duration among adolescents are major public health concerns. To provide theoretical guidance for addressing these issues, Dong Rubao et al. proposed a holistic health-based model in which physical activity promotes adolescent mental health through the multiple mediating effects of general self-efficacy and sleep duration. If valid, this model could offer both theoretical and practical guidance for integrated solutions to insufficient physical activity, inadequate sleep, and poor mental health among adolescents. At the same time, it may maximize health promotion effects while saving time for adolescents with heavy academic workloads, and encourage the adoption of a holistic perspective in health promotion efforts. However, the original study was based only on cross-sectional survey data, leaving uncertainty about the model's validity across different social contexts. Since adolescent physical activity, sleep duration, and mental health are influenced by diverse factors, particularly the physical activity environment, further validation is needed. OBJECTIVE: This study aimed to examine the validity of the adolescent health promotion model across different social environments and to provide evidence for its practical application. From 2021 to 2023, we randomly extracted 1,073 sets of survey data per year from an adolescent health database containing measures of physical activity, sleep duration, general self-efficacy, and mental health. The data were collected in three distinct contexts: the normalized prevention and control stage of COVID-19 in 2021, the outbreak stage in 2022, and the post-control stage in 2023. These datasets were used to test the theoretical model constructed by Dong Rubao et al. METHODS: Cross-sectional surveys conducted over three consecutive years provided data on adolescent level of physical activity (PAL), sleep duration (SD), general self-efficacy (GSE), and mental health (MH). Normality and correlation analyses were performed using SPSS 26.0. Bootstrap inference for model coefficients was conducted using PROCESS v4.1 by Andrew F. Hayes (Model 4). Effect size tests for the structural equation model were conducted in AMOS 26.0. RESULTS: The average sleep duration(SD) for adolescents was 440.15, 430.14, and 441.80 mins/day respectively (F = 9.62, p < 0.001), PAL was 2.54, 2.35, and 2.46 respectively (F = 18.87, p < 0.001), GSE was 2.65, 2.36, and 2.71 respectively (F = 74.53, p < 0.001), and MH was 1.54, 1.86, and 1.57 respectively (F = 87.31, < 0.001); ANOVA results showed significant differences. There were significantly correlated with each other among average of PAL, SD, GSE and MH. The total effects of the model were - 0.196, - 0.338, and - 0.221, respectively, all with P < 0.001; the direct effects were - 0.089, - 0.230, and - 0.117, respectively, all with P < 0.001; the total indirect effects were - 0.107, - 0.107, and - 0.104, respectively; with PAL-->SD-->MH was - 0.077, - 0.051, and - 0.063, and PAL-->GSE-->MH was - 0.031, - 0.057, and - 0.041, all with a significant meaning in the Bias-Corrected 95%CI test. However, during the COVID-19 outbreak, few fit indices of the model did not reach ideal values. SD and GSE play multiple mediating roles in Physical and Mental Health Promotion Model for Adolescent. CONCLUSION: The adolescent health promotion model is generally valid across different social environments. However, in contexts lacking sufficient PA opportunities, the model shows relatively poorer fit. In practice, health promotion among adolescents should address insufficient PA, high prevalence of mental health problems, and inadequate sleep duration as interrelated issues, in order to achieve more comprehensive effects. FAU - Dou, Kai-Yun AU - Dou KY AD - College of Physical Education and Health, Guangxi Normal University, Guilin, Guangxi, 541006, China. FAU - Dong, Ru-Bao AU - Dong RB AD - College of Physical Education and Health, Guangxi Normal University, Guilin, Guangxi, 541006, China. dongrubao05@163.com. FAU - Huang, Jiaben AU - Huang J AD - Qingyuan Polytechnic, Qingyuan, Guangdong, 511510, China. LA - eng GR - No.17BTY081/National Social Science Fund of China/ PT - Journal Article DEP - 20251202 PL - England TA - Arch Public Health JT - Archives of public health = Archives belges de sante publique JID - 9208826 PMC - PMC12777160 OTO - NOTNLM OT - Adolescents OT - Mental health OT - Pandemic OT - Physical activity OT - Self-efficacy OT - Sleep COIS- Declarations. Ethical approval and consent to participate: The study was approved by the Ethics Committee at the school of physical education of Guizhou Normal University of China (No.20170729). All methods were carried out in accordance with relevant guidelines and regulations. Before the start of this study, informed consent was obtained from all participants. The respondents were recruited through oral propaganda. Before recruitment, a survey obtained the consent of the principal of the school where the interviewees (teenagers) belong, and required the orally recruited teenagers to bring back a "Parent Informed Consent Form" to their parents for reading and signing. Only the teenagers who submitted the signed "Parents Informed Consent Form" for "Consent" could participated in the survey. And informed them have the right to withdraw freely from the survey. Consent for publication: No individual or indemnifiable data is being published as part of this manuscript. Competing interests: The authors declare no competing interests. EDAT- 2025/12/03 07:41 MHDA- 2025/12/03 07:42 PMCR- 2025/12/02 CRDT- 2025/12/03 00:27 PHST- 2025/08/16 00:00 [received] PHST- 2025/11/25 00:00 [accepted] PHST- 2025/12/03 07:42 [medline] PHST- 2025/12/03 07:41 [pubmed] PHST- 2025/12/03 00:27 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - 10.1186/s13690-025-01806-x [pii] AID - 1806 [pii] AID - 10.1186/s13690-025-01806-x [doi] PST - epublish SO - Arch Public Health. 2025 Dec 2;84(1):4. doi: 10.1186/s13690-025-01806-x. PMID- 41331898 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260107 LR - 20260109 IS - 2055-5784 (Print) IS - 2055-5784 (Electronic) IS - 2055-5784 (Linking) VI - 12 IP - 1 DP - 2025 Dec 2 TI - Unlocking the power of groups in youth sport: a proof-of-concept evaluation of the Together For Us (T4Us) intervention. PG - 2 LID - 10.1186/s40814-025-01741-2 [doi] LID - 2 AB - BACKGROUND: Together For Us (T4Us) is a newly developed and evidence-informed social identity intervention for youth sport. Drawing on theoretical underpinnings of social identity theory and previous shared leadership intervention research in sport, T4Us leverages athlete leaders to foster a shared sense of social identity within the team. METHODS: The purpose of this study was to conduct an initial feasibility study (Study 1) and a proof-of-concept evaluation (Study 2) to determine whether T4Us enhanced social identity and assessed the intervention implementation. RESULTS: In Study 1, five competitive youth ice hockey teams (mean age = 13.0 years) completed T4Us at midseason. Overall, athlete leaders (n = 19) and coaches (n = 4) expressed support for the acceptability and feasibility of the initial T4Us workshop in a youth sport setting, including the creation of a unique team "trademark" and the shared leadership mapping exercise. Participants also recommended possible improvements to T4Us (e.g., intervention timing and follow-up booster sessions to reinforce content). In Study 2, a total of 14 competitive youth soccer teams (mean age = 14.7 years) completed the revised T4Us at midseason. Descriptive results highlight that athletes' perceptions of social identity were higher at post-intervention in comparison with pre-intervention. Post-intervention implementation evaluation results revealed that the teams used the game plan to support the team trademark, and athlete leaders and coaches encouraged team members to act according to the team game plan (scores > 5 on a 7-point scale). Interviews with athlete leaders described the different ways in which T4Us enhanced social identity within the team. CONCLUSION: Overall, the initial feasibility evidence and the proof-of-concept evaluation support the further development of T4Us, including a randomized-controlled T4Us protocol. CI - (c) 2025. The Author(s). FAU - Bruner, Mark W AU - Bruner MW AUID- ORCID: 0000-0003-3534-3321 AD - School of Physical and Health Education, Nipissing University, North Bay, Ontario, Canada. markb@nipissingu.ca. FAU - McLaren, Colin D AU - McLaren CD AD - Department of Experiential Studies in Community and Sport, Cape Breton University, Sydney, Nova Scotia, Canada. FAU - Schertzinger, Meredith AU - Schertzinger M AD - School of Physical and Health Education, Nipissing University, North Bay, Ontario, Canada. FAU - Boardley, Ian D AU - Boardley ID AD - School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, England. FAU - Martin, Luc J AU - Martin LJ AD - School of Kinesiology and Health Studies, Queen's University, Kingston, ON, Canada. FAU - Slatcher, Richard B AU - Slatcher RB AD - Department of Psychology, University of Georgia, Athens, GA, USA. FAU - Vella, Stewart AU - Vella S AD - School of Psychology, University of Wollongong, Wollongong, Australia. FAU - Carre, Justin M AU - Carre JM AD - School of Psychology, Nipissing University, North Bay, Ontario, Canada. FAU - Fransen, Katrien AU - Fransen K AD - Department of Movement Sciences, KU Leuven, Leuven, Belgium. LA - eng GR - 435-2021-0943/Social Sciences and Humanities Research Council/ PT - Journal Article DEP - 20251202 PL - England TA - Pilot Feasibility Stud JT - Pilot and feasibility studies JID - 101676536 PMC - PMC12777403 OTO - NOTNLM OT - Intervention OT - Social identity OT - Sport OT - Youth development COIS- Declarations. Ethics approval and consent to participate: This research received ethical approval from the lead author's institutional research ethics board (REB no. 102270 and 102959). Informed consent and/or assent was granted by parents and participants. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2025/12/03 07:41 MHDA- 2025/12/03 07:42 PMCR- 2025/12/02 CRDT- 2025/12/03 00:21 PHST- 2024/04/07 00:00 [received] PHST- 2025/11/08 00:00 [accepted] PHST- 2025/12/03 07:42 [medline] PHST- 2025/12/03 07:41 [pubmed] PHST- 2025/12/03 00:21 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - 10.1186/s40814-025-01741-2 [pii] AID - 1741 [pii] AID - 10.1186/s40814-025-01741-2 [doi] PST - epublish SO - Pilot Feasibility Stud. 2025 Dec 2;12(1):2. doi: 10.1186/s40814-025-01741-2. PMID- 41331876 OWN - NLM STAT- MEDLINE DCOM- 20260108 LR - 20260110 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2025 Dec 3 TI - Associations of nutritional habits, lifestyle, and demographic factors with mental health outcomes among university students in Lebanon: a cross-sectional study. PG - 91 LID - 10.1186/s12889-025-25664-y [doi] LID - 91 AB - BACKGROUND: Growing evidence highlights the role of dietary habits in shaping mental health outcomes, particularly among young adults. This study aimed to examine the associations between dietary intake of fat and sugar and mental health outcomes-specifically depression and anxiety-among university students in Lebanon. METHODS: A cross-sectional survey was conducted between January and May 2025 across five major universities in Lebanon. A total of 646 students aged 18-30 years completed a self-administered online questionnaire. Dietary intake of fats and free sugars was assessed using the validated Dietary Fat and Free Sugar Questionnaire (DFS). Mental health outcomes were measured using the Patient Health Questionnaire-9 for depression (PHQ-9) and the General Anxiety Disorder (GAD-7). Descriptive statistics, bivariate analyses, and logistic regressions were performed to evaluate associations between dietary fat or sugar intake and mental health outcomes, adjusting for relevant confounders. RESULTS: Among 646 university students (64.9% females, mean age = 20.8 +/- 3.7 years), 74.8% reported depressive symptoms, 72.1% reported anxiety. The mean consumption of fat and sugar was 29 +/- 6.7 and 15 +/- 4.4, respectively using the DFS Fat and Sugar subscales. In multivariable analysis, depression was significantly associated with overall health, moderate alcohol consumption, physical activity, fat intake and sugar intake, while anxiety was significantly linked to overall health, caffeine consumption, sugar intake, but not fat intake. CONCLUSIONS: Our findings call for integrated, holistic health promotion strategies within university settings that combine nutrition education, physical activity encouragement and mental health support. CI - (c) 2025. The Author(s). FAU - Boutros, Paula Hage AU - Boutros PH AD - Department of Nutrition, Faculty of Health Sciences, Modern University for Business and Science, Ramiz Sarkis, Beirut, 11-37501, Lebanon. phage@mubs.edu.lb. FAU - Papazian, Tatiana AU - Papazian T AD - Department of Nutrition, Faculty of Pharmacy, Saint Joseph University of Beirut, Riad El Solh, Beirut, 11-5076, Lebanon. FAU - Tawtah, Lynn AU - Tawtah L AD - Department of Nutrition, Faculty of Pharmacy, Saint Joseph University of Beirut, Riad El Solh, Beirut, 11-5076, Lebanon. FAU - Merhi, Samar AU - Merhi S AD - Faculty of Nursing and Health Sciences, Notre Dame University-Louaize, Zouk Mosbeh, Lebanon. FAU - Salameh, Estelle AU - Salameh E AD - Faculty of Nursing and Health Sciences, Notre Dame University-Louaize, Zouk Mosbeh, Lebanon. FAU - Fares, Jessy El Hayek AU - Fares JEH AD - Faculty of Nursing and Health Sciences, Notre Dame University-Louaize, Zouk Mosbeh, Lebanon. LA - eng PT - Journal Article DEP - 20251203 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 RN - 0 (Dietary Fats) RN - 0 (Dietary Sugars) SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Lebanon/epidemiology MH - Male MH - Universities MH - Young Adult MH - Adult MH - *Students/psychology/statistics & numerical data MH - Adolescent MH - *Feeding Behavior/psychology MH - *Life Style MH - *Depression/epidemiology MH - Surveys and Questionnaires MH - *Anxiety/epidemiology MH - *Mental Health/statistics & numerical data MH - Dietary Fats/administration & dosage MH - Sociodemographic Factors MH - Dietary Sugars/administration & dosage PMC - PMC12781419 OTO - NOTNLM OT - Anxiety OT - Cross-sectional studies OT - Depression OT - Fat intake OT - Lebanon OT - Mental health OT - Physical activity OT - Students OT - Sugar intake OT - Surveys and questionnaires COIS- Declarations. Ethics approval and consent to participate: The research protocol was approved by the Modern University for Business and Science (MUBS) Institutional Review Board (MU-20241220-52), the Notre Dame University-Louaize (NDU) Institutional Review Board (IRB 202501), and the ethical committee of Saint Joseph University (USJ) (CER-2025-82) before data collection and was performed in accordance with the Declaration of Helsinki. Participants were informed about the purpose of the study before participation and provided informed consent by selecting "I agree" on the first page of the survey hosted on the online platform Google Forms. Only consenting individuals were able to proceed. The survey was anonymous, with no personal identifiers collected. Participants were informed they could withdraw at any time without penalty. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/03 07:41 MHDA- 2026/01/08 07:13 PMCR- 2025/12/03 CRDT- 2025/12/03 00:19 PHST- 2025/08/25 00:00 [received] PHST- 2025/11/12 00:00 [accepted] PHST- 2026/01/08 07:13 [medline] PHST- 2025/12/03 07:41 [pubmed] PHST- 2025/12/03 00:19 [entrez] PHST- 2025/12/03 00:00 [pmc-release] AID - 10.1186/s12889-025-25664-y [pii] AID - 25664 [pii] AID - 10.1186/s12889-025-25664-y [doi] PST - epublish SO - BMC Public Health. 2025 Dec 3;26(1):91. doi: 10.1186/s12889-025-25664-y. PMID- 41331706 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251220 LR - 20251222 IS - 2055-5784 (Print) IS - 2055-5784 (Electronic) IS - 2055-5784 (Linking) VI - 11 IP - 1 DP - 2025 Dec 2 TI - The Veggie Vouchers intervention to promote SNAP fruit and vegetable incentive program use for families with food insecurity: a single arm feasibility study. PG - 157 LID - 10.1186/s40814-025-01732-3 [doi] LID - 157 AB - BACKGROUND: The Supplemental Nutrition Assistance Program (SNAP) has financial incentive programs where recipients can purchase fruits and vegetables (F&V) at select sites for half price or less, leading to increased F&V consumption and projected savings in healthcare costs. Yet, limited awareness and uptake of these programs present barriers to widespread utilization, thus limiting potential impact. OBJECTIVE: The Veggie Vouchers intervention was designed to increase awareness and uptake of a SNAP F&V incentive program in South Carolina among families with children 2-17 years of age. The primary aim of this study was to determine intervention feasibility and acceptability among caregivers and pediatricians. Patterns of preliminary efficacy were secondarily examined for changes in diet-related outcomes. METHODS: This single-arm feasibility study leveraged social determinants of health screenings in a pediatric clinic to identify families who were eligible for a SNAP F&V incentive program. Eligible caregivers received brief education about this program from their pediatrician and an initial free trial to incentivize uptake. Free trial redemption rates were tracked, along with subsequent SNAP F&V incentive program use after the free trial ended. Surveys assessed intervention acceptability and changes in household food security, nutrition security, and children's dietary intake. RESULTS: Caregivers (n = 91; 100% female; 77% Black) and pediatricians (n = 37) were enrolled within 10 months. Most caregivers (70.3%) used their free trial (redeemers), with 58% of "non-redeemers" reporting transportation challenges as reasons for non-redemption. Over 91% of "redeemers" were satisfied with the amount, variety, and quality of F&V; 90.5% reported the free trial made it easier for them and their child to eat more F&V; and 18.8% utilized the SNAP F&V incentive program after the free trial ended. Most assessment time points achieved >/= 70% survey completion rates. Pediatricians (88.9%) felt the intervention was easy to implement, and 100% reported minimal-to-no disruptions in clinic flow. Initial patterns indicated potential improvements in household food security and nutrition security throughout the intervention for "redeemers," compared to "non-redeemers". CONCLUSIONS: Findings support the feasibility and acceptability of the Veggie Vouchers intervention, yet additional strategies should be explored in a larger randomized controlled trial to enhance sustained SNAP F&V program use. TRIAL REGISTRATION: ClinicalTrials.gov, NCT06593028. Retrospectively registered on September 11, 2024, https://clinicaltrials.gov/study/NCT06593028 . CI - (c) 2025. The Author(s). FAU - Adams, Elizabeth L AU - Adams EL AUID- ORCID: 0000-0002-5602-8470 AD - Department of Exercise Science, Arnold School of Public Health, University of South Carolina, 921 Assembly St, Columbia, SC, 29208, USA. elizabeth-adams@sc.edu. AD - Research Center for Child Well-Being, University of South Carolina, 1400 Pickens St, Suite 400, Columbia, SC, 29201, USA. elizabeth-adams@sc.edu. FAU - Savidge, Meghan AU - Savidge M AD - Department of Exercise Science, Arnold School of Public Health, University of South Carolina, 921 Assembly St, Columbia, SC, 29208, USA. FAU - Reesor-Oyer, Layton AU - Reesor-Oyer L AD - Department of Health Education and Behavior, College of Health and Human Performance, University of Florida, PO Box 118210, Gainesville, FL, 32611, USA. FAU - Draper, Carrie AU - Draper C AD - Department of Health Promotion, Education, and Behavior, Arnold School of Public Health, University of South Carolina, 915 Greene St, Columbia, SC, 29208, USA. FAU - Steeves, Elizabeth Anderson AU - Steeves EA AD - Center for Nutrition and Health Impact, 14301 FNB Parkway, Suite 100, Omaha, NE, 68154, USA. FAU - Bean, Melanie K AU - Bean MK AD - Department of Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, 2303N. Parham Road, Suite 1, Richmond, VA, 23229, USA. FAU - Figueroa, Roger AU - Figueroa R AD - Division of Nutritional Sciences, College of Human Ecology, Cornell University, 116 Reservoir Avenue, Ithaca, NY, 14853, USA. FAU - Stephenson, Katie AU - Stephenson K AD - Department of Pediatrics, University of South Carolina School of Medicine Columbia, 14 Medical Park Road, Suite 400, Columbia, SC, 29203, USA. FAU - Weaver, R Glenn AU - Weaver RG AD - Department of Exercise Science, Arnold School of Public Health, University of South Carolina, 921 Assembly St, Columbia, SC, 29208, USA. AD - Research Center for Child Well-Being, University of South Carolina, 1400 Pickens St, Suite 400, Columbia, SC, 29201, USA. FAU - Armstrong, Bridget AU - Armstrong B AD - Department of Exercise Science, Arnold School of Public Health, University of South Carolina, 921 Assembly St, Columbia, SC, 29208, USA. AD - Research Center for Child Well-Being, University of South Carolina, 1400 Pickens St, Suite 400, Columbia, SC, 29201, USA. FAU - Beets, Michael AU - Beets M AD - Department of Exercise Science, Arnold School of Public Health, University of South Carolina, 921 Assembly St, Columbia, SC, 29208, USA. AD - Research Center for Child Well-Being, University of South Carolina, 1400 Pickens St, Suite 400, Columbia, SC, 29201, USA. FAU - Burkart, Sarah AU - Burkart S AD - Department of Exercise Science, Arnold School of Public Health, University of South Carolina, 921 Assembly St, Columbia, SC, 29208, USA. AD - Research Center for Child Well-Being, University of South Carolina, 1400 Pickens St, Suite 400, Columbia, SC, 29201, USA. LA - eng SI - ClinicalTrials.gov/NCT06593028 GR - P20 GM130420/GM/NIGMS NIH HHS/United States GR - R25 HL126146/HL/NHLBI NIH HHS/United States GR - P20GM130420/GM/NIGMS NIH HHS/United States GR - R25HL126146 sub-contract #13972sc/NHLBI Division of Intramural Research/ PT - Journal Article DEP - 20251202 PL - England TA - Pilot Feasibility Stud JT - Pilot and feasibility studies JID - 101676536 PMC - PMC12715973 OTO - NOTNLM OT - Federal Food Assistance OT - Food security OT - Low income OT - Nutrition incentive OT - Nutrition security OT - Produce incentive OT - Social determinants of health OT - Supplemental Nutrition Assistance Program COIS- Declarations. Ethics approval and consent to participate: This study was approved by the Institutional Review Board at the University of South Carolina prior to enrollment of the first participant. All caregivers provided electronic consent prior to data collection. The Institutional Review Board determined no physician consent was needed. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2025/12/03 01:16 MHDA- 2025/12/03 01:17 PMCR- 2025/12/02 CRDT- 2025/12/02 23:58 PHST- 2024/09/12 00:00 [received] PHST- 2025/10/18 00:00 [accepted] PHST- 2025/12/03 01:17 [medline] PHST- 2025/12/03 01:16 [pubmed] PHST- 2025/12/02 23:58 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - 10.1186/s40814-025-01732-3 [pii] AID - 1732 [pii] AID - 10.1186/s40814-025-01732-3 [doi] PST - epublish SO - Pilot Feasibility Stud. 2025 Dec 2;11(1):157. doi: 10.1186/s40814-025-01732-3. PMID- 41331657 OWN - NLM STAT- MEDLINE DCOM- 20260818 LR - 20260820 IS - 2948-2933 (Electronic) IS - 2948-2925 (Print) IS - 2948-2925 (Linking) VI - 39 IP - 4 DP - 2026 Aug TI - Sex Determination Based on Posterior Mandibular Measurements using Three-Dimensional Cone-Beam Computed Tomography Images. PG - 3386-3400 LID - 10.1007/s10278-025-01755-5 [doi] AB - The objective of this study was to evaluate the reliability and predictive ability of specific anthropometric mandibular measurements on three-dimensional (3D) reconstructed surfaces of cone-beam computed tomography (CBCT) records for sex determination. The study sample analyzed volumetric data from cone-beam computed tomography (CBCT) records of 204 Greek individuals aged 18-70 years, who sought general dental treatment at the School of Dentistry, National and Kapodistrian University of Athens, Greece. Patient records were screened for eligibility based on predefined inclusion criteria. The sample was distributed by sex and further categorized into four distinct age groups. Volumetric data of 204 patients (equally distributed between sexes) were reprocessed with the ViewBox 4 software, according to inclusion-exclusion criteria. Ten anatomical landmarks visible on three-dimensional CBCT reconstructions were digitally traced using the ViewBox 4 software, including superior points of the right and left condyles, the most proximal points of the inner poles of the right and left condyles, the inferior points of the right and left sigmoid notches, the superior points of the right and left coronoid processes and the right and left Gonion. This cross-sectional study employed a binary logistic regression (BLR) model for statistical analysis. All linear parameters exhibited statistically significant differences between sexes whereas angular measurements did not demonstrate a statistically significant difference. The developed model yielded an accuracy of 83.4% in predicting sex. Specific linear measurements are reliable predictors of sex and may be applied in forensic science as a supplementary method. CI - (c) 2025. The Author(s) under exclusive licence to Society for Imaging Informatics in Medicine. FAU - Christoloukas, Nikolaos AU - Christoloukas N AUID- ORCID: 0009-0004-3530-2639 AD - Department of Oral Diagnosis and Radiology, School of Dentistry, National and Kapodistrian University of Athens, 2 Thivon Str, 115 27, Athens, Greece. FAU - Mitsea, Anastasia AU - Mitsea A AUID- ORCID: 0000-0003-2833-681X AD - Department of Oral Diagnosis and Radiology, School of Dentistry, National and Kapodistrian University of Athens, 2 Thivon Str, 115 27, Athens, Greece. anastasiamitsea@gmail.com. FAU - Kovatsi, Leda AU - Kovatsi L AD - Laboratory of Forensic Medicine and Toxicology, School of Medicine, Aristotle University of Thessaloniki, Thessaloniki, Greece. FAU - Angelopoulos, Christos AU - Angelopoulos C AD - Department of Oral Diagnosis and Radiology, School of Dentistry, National and Kapodistrian University of Athens, 2 Thivon Str, 115 27, Athens, Greece. LA - eng PT - Journal Article DEP - 20251202 PL - Switzerland TA - J Imaging Inform Med JT - Journal of imaging informatics in medicine JID - 9918663679206676 SB - IM MH - Humans MH - *Cone-Beam Computed Tomography/methods MH - Female MH - *Imaging, Three-Dimensional/methods MH - Adult MH - Middle Aged MH - *Mandible/diagnostic imaging/anatomy & histology MH - Male MH - Adolescent MH - Aged MH - Young Adult MH - Reproducibility of Results MH - Greece MH - *Sex Determination by Skeleton/methods MH - Cross-Sectional Studies PMC - PMC13481619 OTO - NOTNLM OT - 3D reconstructed surfaces OT - CBCT OT - Mandibular measurements OT - Sex determination COIS- Declarations. Ethical Approval: The study was conducted in accordance with the Declaration of Helsinki and approved by the Research and Ethics Committee of the School of Dentistry, National and Kapodistrian University of Athens, Greece (27.1.2025/677). Consent to Participate: Informed consent was obtained from all subjects involved in the study. Conflict of interest: The authors declare no competing interests. EDAT- 2025/12/03 01:16 MHDA- 2026/08/18 07:46 PMCR- 2025/12/02 CRDT- 2025/12/02 23:57 PHST- 2025/08/02 00:00 [received] PHST- 2025/11/10 00:00 [accepted] PHST- 2025/11/08 00:00 [revised] PHST- 2026/08/18 07:46 [medline] PHST- 2025/12/03 01:16 [pubmed] PHST- 2025/12/02 23:57 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - 10.1007/s10278-025-01755-5 [pii] AID - 1755 [pii] AID - 10.1007/s10278-025-01755-5 [doi] PST - ppublish SO - J Imaging Inform Med. 2026 Aug;39(4):3386-3400. doi: 10.1007/s10278-025-01755-5. Epub 2025 Dec 2. PMID- 41331591 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2025 Dec 2 TI - Development and initial validation of the adolescent exercise habits scale among Chinese population. PG - 82 LID - 10.1186/s12889-025-25818-y [doi] LID - 82 AB - BACKGROUND: Establishing regular exercise habits during adolescence is essential for fostering lifelong physical activity participation. Despite its importance, reliable and culturally appropriate tools to assess exercise habits among Chinese adolescents remain limited. This study aimed to develop and validate the adolescent exercise habit scale (AEHS), a psychometrically sound instrument for assessing self-reported exercise habits in this population. METHODS: Grounded in a multidimensional conceptual framework, the initial 33-item pool was generated based on literature review and expert consultation. A total of 1346 students aged 12 to 18 completed the preliminary version of the scale. The sample was randomly divided for item analysis, exploratory factor analysis (EFA), and confirmatory factor analysis (CFA). Reliability was assessed using Cronbach's alpha, while validity was examined through construct validity, convergent validity, and preliminary criterion-related evidence. In addition, we employed a percentile-based method to classify adolescents' exercise habit levels according to their scale scores. RESULTS: The final AEHS consisted of 12 items loading on three dimensions: exercise consistency, self-motivation, and integration of exercise into daily life. The AEHS showed acceptable internal consistency, content validity, convergent validity and criterion-related validity (Cronbach's alpha ranged from 0.705 to 0.855, CVI values ranged from 0.79 to 0.87, AVE values ranged from 0.378 to 0.603, and correlation coefficients ranged from 0.564 to 0.659). The AEHS also enables the classification of adolescents' exercise habits into low, moderate, and high levels based on their total scores. CONCLUSIONS: Overall, the AEHS appears to be a valid and reliable tool for evaluating adolescent exercise habits in Chinese contexts and may contribute to more targeted interventions in physical activity promotion. FAU - Wu, Jin AU - Wu J AD - Department of Physical Education, Zhejiang Wanli University, 8 Qianhu South Road, Ningbo, 315100, China. FAU - Yu, Huasen AU - Yu H AD - School of Physical Education, Qinghai Normal University, 38 Haihu Avenue, Xining, 810008, China. FAU - Li, Liqing AU - Li L AD - School of Physical Education, Xizang Minzu University, 6 Wenhui East Road, Xianyang, 712082, China. FAU - Yang, Yuhang AU - Yang Y AD - Department of Physical Education, College of Education, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China. FAU - Zhang, Zeyang AU - Zhang Z AD - College of Physical Education and Health, East China Normal University, 500 Jianchuan Road, Shanghai, 200241, China. FAU - Hu, Xiaopan AU - Hu X AD - Faculty of Sports Science, Ningbo University, 818 Fenghua Road, Ningbo, 315211, China. FAU - Tuerdi, Zufeiya AU - Tuerdi Z AD - Institute of Physical Education, Xinjiang Normal University, 102 Xinyi Road, Urumqi, Shayibake District, 830054, China. 404460296@qq.com. LA - eng GR - 25CTY030/National Social Science Foundation of China/ PT - Journal Article PT - Validation Study DEP - 20251202 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - Adolescent MH - *Exercise/psychology MH - Female MH - Psychometrics MH - Reproducibility of Results MH - Child MH - Male MH - China MH - Surveys and Questionnaires/standards MH - *Adolescent Behavior/psychology MH - *Habits PMC - PMC12777359 OTO - NOTNLM OT - Adolescents OT - Consistency OT - Daily-life integration OT - Exercise habits OT - Scale development OT - Self-motivation COIS- Declarations. Ethics approval and consent to participate: This scale development study is conducted in compliance with the ethical principles of the 1964 Declaration of Helsinki and its later amendments. The recruitment of participants in this study was approved by the Ethics Review Committee of East China Normal University (protocol number: HR 206-2024). School administrators and parents/legal guardians were informed in advance about the study's purpose, procedures, and voluntary nature. Written informed consent was obtained from all the participants involved in the study. Written informed consent was obtained from all parents/guardians. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/12/03 01:16 MHDA- 2026/06/27 06:47 PMCR- 2025/12/02 CRDT- 2025/12/02 23:55 PHST- 2025/06/27 00:00 [received] PHST- 2025/11/24 00:00 [accepted] PHST- 2026/06/27 06:47 [medline] PHST- 2025/12/03 01:16 [pubmed] PHST- 2025/12/02 23:55 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - 10.1186/s12889-025-25818-y [pii] AID - 25818 [pii] AID - 10.1186/s12889-025-25818-y [doi] PST - epublish SO - BMC Public Health. 2025 Dec 2;26(1):82. doi: 10.1186/s12889-025-25818-y. PMID- 41330823 OWN - NLM STAT- MEDLINE DCOM- 20260409 LR - 20260409 IS - 1399-0020 (Electronic) IS - 0901-5027 (Linking) VI - 55 IP - 5 DP - 2026 May TI - Head orientation method affects symmetry assessment. PG - 563-568 LID - S0901-5027(25)01502-4 [pii] LID - 10.1016/j.ijom.2025.11.007 [doi] AB - Head orientation is a key component of orthognathic surgical planning, and sets the reference frame on which clinical assessment and surgical planning are performed. Hard tissue-based (HT) and soft tissue-based (ST) head orientation methods are commonly used, but their impact on symmetry is unclear. The purpose of this study was to analyze the impact of head orientation technique on symmetry assessment. Patients who underwent orthognathic surgery at a single center over 13 months were studied retrospectively. Preoperative computed tomography were oriented using HT and ST methods, and the roll and mediolateral positions of the maxillary dental midline (U1) and pogonion (Pog) were compared. In fifty-seven eligible subjects, the median roll difference was 0.64 degrees (range 0-2.85 degrees ; P = 0.003), and the median absolute mediolateral position difference was 0.9 mm at U1 and 1.2 mm at Pog (both P = 0.003). The reliability of the both methods was excellent (intra-class correlation coefficient > 0.974; both P < 0.001). Use of HT and ST head orientation methods resulted in differing symmetry assessments, which could result in clinically significant deviations. Clinicians must balance the advantages and disadvantages of the HT and ST methods to properly apply each to their surgical workup protocols. CI - Copyright (c) 2026 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Han, M D AU - Han MD AD - Department of Oral and Maxillofacial Surgery, University of Illinois Chicago College of Dentistry, Chicago, IL, USA. Electronic address: hanmd@uic.edu. FAU - Graca, S AU - Graca S AD - Private Practice, Chicago, IL, USA. LA - eng PT - Journal Article DEP - 20251201 PL - Denmark TA - Int J Oral Maxillofac Surg JT - International journal of oral and maxillofacial surgery JID - 8605826 SB - IM MH - Humans MH - Female MH - Male MH - Retrospective Studies MH - Adult MH - *Head/diagnostic imaging/anatomy & histology MH - Tomography, X-Ray Computed MH - *Orthognathic Surgical Procedures/methods MH - Cephalometry/methods MH - Adolescent MH - Reproducibility of Results OTO - NOTNLM OT - Computer-assisted three-dimensional imaging OT - Dentofacial deformities OT - Facial asymmetry OT - Malocclusion OT - Orthognathic surgery COIS- Conflict of Interest None. EDAT- 2025/12/03 01:16 MHDA- 2026/04/10 00:33 CRDT- 2025/12/02 22:08 PHST- 2025/07/10 00:00 [received] PHST- 2025/11/11 00:00 [revised] PHST- 2025/11/14 00:00 [accepted] PHST- 2026/04/10 00:33 [medline] PHST- 2025/12/03 01:16 [pubmed] PHST- 2025/12/02 22:08 [entrez] AID - S0901-5027(25)01502-4 [pii] AID - 10.1016/j.ijom.2025.11.007 [doi] PST - ppublish SO - Int J Oral Maxillofac Surg. 2026 May;55(5):563-568. doi: 10.1016/j.ijom.2025.11.007. Epub 2025 Dec 1. PMID- 41330693 OWN - NLM STAT- MEDLINE DCOM- 20251218 LR - 20260510 IS - 1873-734X (Electronic) IS - 1010-7940 (Linking) VI - 67 IP - 12 DP - 2025 Dec 1 TI - Short- and Mid-term Cardiac Ventricular Remodelling After Pulmonary Valve Replacement in Adults With Repaired Tetralogy of Fallot. LID - ezaf432 [pii] LID - 10.1093/ejcts/ezaf432 [doi] AB - OBJECTIVES: Pulmonary valve replacement (PVR) in patients with repaired tetralogy of Fallot (rTOF) is performed to preserve right ventricular (RV) function and improve exercise capacity. The effects of PVR extend beyond the RV, influencing left ventricular (LV) performance through biventricular interdependence. This study aimed to evaluate the rate of structural and functional ventricular adaptation after PVR, with a focus on risk stratification and clinical management. METHODS: We prospectively enrolled 74 patients with rTOF who underwent surgical PVR at Bambino Gesu Paediatric Hospital. The mean age at initial repair was 0.8 years and at PVR 17.2 years; mean body surface area 1.74 m2. Cardiovascular magnetic resonance (CMR) and cardiopulmonary exercise testing (CPET) were performed preoperatively, 6 months after surgery, and at midterm follow-up (median 57 months). Morphological and functional changes were assessed with ANOVA, and correlations between ventricular parameters were analysed. Receiver-operating-characteristic (ROC) curves identified thresholds for RV normalization. RESULTS: Indexed RV end-diastolic volume (RVEDVi) decreased from 166.8 +/- 30.1 mL/m2 (95% confidence interval [CI] 162.5-171.1) to 121.1 +/- 22.4 mL/m2 (95% CI 117.0-125.2) postoperatively and 130.2 +/- 23.5 mL/m2 (95% CI 126.1-134.3) at follow-up. Indexed RV end-systolic volume (RVESVi) decreased from 85.7 +/- 21.5 mL/m2 (95% CI 81.2-90.2) to 56.1 +/- 14.9 mL/m2 (95% CI 52.6-59.6) and 61.9 +/- 16.3 mL/m2 (95% CI 58.1-65.7). RV ejection fraction improved from 49.2% (95% CI 47.3-51.1) to 55.6% (95% CI 53.6-57.6). ROC analysis identified pre-operative cut-offs RVEDVi 0.90), indicating variable agreement across parameters.ConclusionsAI-based cephalometric analysis using OrthoDx demonstrated limited accuracy in patients with CLP. Examiner intervention reduced the variability of certain cephalometric measurements, making the results closer to the manual group, supporting the role of clinician-supervised AI as a complementary rather than replacement tool. FAU - Karagoz, Hazal AU - Karagoz H AUID- ORCID: 0000-0002-7606-8576 AD - Department of Orthodontics, Faculty of Dentistry, Hacettepe University, Ankara, Turkiye. RINGGOLD: 743742 FAU - Akarsu-Guven, Bengisu AU - Akarsu-Guven B AUID- ORCID: 0000-0003-4549-8351 AD - Department of Orthodontics, Faculty of Dentistry, Hacettepe University, Ankara, Turkiye. RINGGOLD: 743742 FAU - Aksu, Muge AU - Aksu M AUID- ORCID: 0000-0002-4705-460X AD - Department of Orthodontics, Faculty of Dentistry, Hacettepe University, Ankara, Turkiye. RINGGOLD: 743742 LA - eng PT - Comparative Study PT - Journal Article DEP - 20251202 PL - United States TA - Cleft Palate Craniofac J JT - The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association JID - 9102566 SB - IM MH - Humans MH - *Cephalometry/methods MH - *Artificial Intelligence MH - Female MH - *Cleft Palate/diagnostic imaging MH - *Cleft Lip/diagnostic imaging MH - Reproducibility of Results MH - Male MH - Child MH - Observer Variation MH - Software MH - Adolescent OTO - NOTNLM OT - artificial intelligence OT - cephalometry OT - cleft lip and palate COIS- Declaration of Conflicting InterestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/12/02 19:16 MHDA- 2026/08/11 12:37 CRDT- 2025/12/02 14:04 PHST- 2026/08/11 12:37 [medline] PHST- 2025/12/02 19:16 [pubmed] PHST- 2025/12/02 14:04 [entrez] AID - 10.1177/10556656251400212 [doi] PST - ppublish SO - Cleft Palate Craniofac J. 2026 Sep;63(9):2927-2937. doi: 10.1177/10556656251400212. Epub 2025 Dec 2. PMID- 41329746 OWN - NLM STAT- MEDLINE DCOM- 20251202 LR - 20251205 IS - 1932-6203 (Electronic) IS - 1932-6203 (Linking) VI - 20 IP - 12 DP - 2025 TI - Modifiable risk factors for inflammatory bowel disease in Kuwait: A cross-sectional analysis. PG - e0338005 LID - 10.1371/journal.pone.0338005 [doi] LID - e0338005 AB - Inflammatory bowel disease (IBD), a lifelong inflammatory condition of the gastrointestinal tract, is influenced by complex interactions between genetics and environmental exposures. While IBD rates have increased globally, largely due to Westernized lifestyle shifts, the contributors to IBD in Kuwait remain poorly understood. This cross-sectional study aimed to explore lifestyle, dietary, and occupational exposures associated with IBD in this unique population. A total of 520 adults (412 with IBD and 108 without IBD) completed a 40-item online questionnaire assessing early-life, lifestyle, occupational, and dietary exposures. Of the IBD participants, 174 had ulcerative colitis (UC) and 238 had Crohn's disease (CD). The questionnaire was adapted from a previously validated tool, but was not formally validated in the Kuwaiti population. Associations between these factors and IBD status were analyzed using multivariable logistic regression with adjusted odds ratios (AORs) and 95% confidence intervals (CIs) reported after adjusting for potential confounders. Factors associated with increased odds of IBD included male sex (AOR = 2.487, p = 0.005), younger age (AOR = 0.964, p = 0.004), positive family history (AOR = 2.141, p = 0.023), mentally demanding jobs (AOR = 1.818, p = 0.039), alcohol consumption (AOR = 6.508, p = 0.016), frequent spicy food intake 1-2 times/week (AOR = 2.631, p = 0.008), and prior parasitic infection (AOR = 0.484, p = 0.042). A history of appendectomy was also associated (AOR = 7.158, p = 0.003). Several modifiable exposures were found to be associated with IBD status in Kuwait. These findings underscore the multifactorial nature of IBD. However, the cross-sectional design, reliance on self-reporting, and use of a non-validated instrument limit causal interpretation. Future longitudinal research is needed to better understand temporal relationships. CI - Copyright: (c) 2025 Alhasan, Alshatti. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. FAU - Alhasan, Reem AU - Alhasan R AUID- ORCID: 0000-0003-1718-7599 AD - Faculty of Public Health, Department of Environmental and Occupational Health, Kuwait University, Kuwait, Kuwait. FAU - Alshatti, Talal AU - Alshatti T AD - Faculty of Allied Health Sciences, Department of Physiotherapy, Kuwait University, Kuwait, Kuwait. LA - eng PT - Journal Article DEP - 20251202 PL - United States TA - PLoS One JT - PloS one JID - 101285081 SB - IM MH - Humans MH - Kuwait/epidemiology MH - Male MH - Female MH - Cross-Sectional Studies MH - Adult MH - Risk Factors MH - Middle Aged MH - Surveys and Questionnaires MH - *Inflammatory Bowel Diseases/epidemiology/etiology MH - Life Style MH - *Crohn Disease/epidemiology/etiology MH - Young Adult MH - *Colitis, Ulcerative/epidemiology/etiology MH - Diet MH - Occupational Exposure/adverse effects MH - Adolescent MH - Odds Ratio PMC - PMC12671769 COIS- The authors have declared that no competing interests exist. EDAT- 2025/12/02 19:15 MHDA- 2025/12/02 19:16 PMCR- 2025/12/02 CRDT- 2025/12/02 13:43 PHST- 2025/08/16 00:00 [received] PHST- 2025/11/17 00:00 [accepted] PHST- 2025/12/02 19:16 [medline] PHST- 2025/12/02 19:15 [pubmed] PHST- 2025/12/02 13:43 [entrez] PHST- 2025/12/02 00:00 [pmc-release] AID - PONE-D-25-43895 [pii] AID - 10.1371/journal.pone.0338005 [doi] PST - epublish SO - PLoS One. 2025 Dec 2;20(12):e0338005. doi: 10.1371/journal.pone.0338005. eCollection 2025. PMID- 41328752 OWN - NLM STAT- In-Process LR - 20260409 IS - 1365-2222 (Electronic) IS - 0954-7894 (Linking) VI - 56 IP - 4 DP - 2026 Apr TI - Feasibility of Early Nut Introduction Using Low-Protein Recipes in Healthy Infants: A Single-Arm Prospective Intervention Study (Phase One). PG - 424-426 LID - 10.1111/cea.70192 [doi] FAU - Hamaguchi, Sayaka AU - Hamaguchi S AUID- ORCID: 0009-0002-4885-5991 AD - Allergy Center, National Center for Child Health and Development (NCCHD), Tokyo, Japan. AD - Department of Pediatrics, Tokyo Metropolitan Hiroo Hospital, Tokyo, Japan. FAU - Jimbo, Chisato AU - Jimbo C AD - Allergy Center, National Center for Child Health and Development (NCCHD), Tokyo, Japan. FAU - Yaguchi, Tomoki AU - Yaguchi T AUID- ORCID: 0000-0002-1903-6922 AD - Allergy Center, National Center for Child Health and Development (NCCHD), Tokyo, Japan. FAU - Omori, Marei AU - Omori M AD - Allergy Center, National Center for Child Health and Development (NCCHD), Tokyo, Japan. FAU - Harama, Daisuke AU - Harama D AUID- ORCID: 0000-0002-2967-6739 AD - Allergy Center, National Center for Child Health and Development (NCCHD), Tokyo, Japan. FAU - Umezawa, Kotaro AU - Umezawa K AD - Allergy Center, National Center for Child Health and Development (NCCHD), Tokyo, Japan. FAU - Suzuki, Daichi AU - Suzuki D AUID- ORCID: 0009-0002-5777-7497 AD - Allergy Center, National Center for Child Health and Development (NCCHD), Tokyo, Japan. FAU - Toyokuni, Kenji AU - Toyokuni K AUID- ORCID: 0009-0002-2333-1817 AD - Allergy Center, National Center for Child Health and Development (NCCHD), Tokyo, Japan. FAU - Tano, Narumi AU - Tano N AD - Food Allergy & Atopy Circle in Sayama, Osaka 'Smile Smile', Osaka, Japan. FAU - Tsutsumi, Chiharu AU - Tsutsumi C AD - Department of Health and Nutrition, Sagami Women's University, Sagamihara, Kanagawa, Japan. FAU - Mitsuhashi, Fusako AU - Mitsuhashi F AD - Department of Chemistry, The Nippon Dental University, School of Life Dentistry, Tokyo, Japan. FAU - Fukuie, Tatsuki AU - Fukuie T AUID- ORCID: 0000-0003-4962-2137 AD - Allergy Center, National Center for Child Health and Development (NCCHD), Tokyo, Japan. FAU - Narita, Masami AU - Narita M AD - Department of Pediatrics, Kyorin University School of Medicine, Tokyo, Japan. FAU - Ohya, Yukihiro AU - Ohya Y AUID- ORCID: 0000-0002-1560-3942 AD - Department of Occupational and Environmental Health, Nagoya City University, Nagoya, Japan. FAU - Yamamoto-Hanada, Kiwako AU - Yamamoto-Hanada K AUID- ORCID: 0000-0003-1288-9620 AD - Allergy Center, National Center for Child Health and Development (NCCHD), Tokyo, Japan. LA - eng GR - 23K28010/Japan Society for the Promotion of Science/ GR - 25K00746/Japan Society for the Promotion of Science/ GR - National Center for Child Health and Development/ PT - Journal Article DEP - 20251202 PL - England TA - Clin Exp Allergy JT - Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology JID - 8906443 SB - IM OTO - NOTNLM OT - early introduction OT - feasibility OT - food allergy prevention OT - nut allergy OT - paediatric nutrition OT - recipe OT - weaning EDAT- 2025/12/02 12:56 MHDA- 2025/12/02 12:56 CRDT- 2025/12/02 07:22 PHST- 2025/11/14 00:00 [revised] PHST- 2025/08/25 00:00 [received] PHST- 2025/11/18 00:00 [accepted] PHST- 2025/12/02 12:56 [pubmed] PHST- 2025/12/02 12:56 [medline] PHST- 2025/12/02 07:22 [entrez] AID - 10.1111/cea.70192 [doi] PST - ppublish SO - Clin Exp Allergy. 2026 Apr;56(4):424-426. doi: 10.1111/cea.70192. Epub 2025 Dec 2. PMID- 41327956 OWN - NLM STAT- MEDLINE DCOM- 20251229 LR - 20260516 IS - 1532-7914 (Electronic) IS - 0163-5581 (Linking) VI - 78 IP - 2 DP - 2026 TI - The Nutritional Impact of Childhood Cancer: Insights from a Feasibility Cohort Study. PG - 111-122 LID - 10.1080/01635581.2025.2576212 [doi] AB - Malnutrition, including undernutrition and overnutrition, affects survival, treatment response, and quality of life in children with cancer. However, its prevalence, trajectory, and clinical impact remain underexplored. This non-randomized pilot feasibility study evaluated the feasibility of comprehensive nutritional data collection and documented nutritional status from diagnosis through treatment in 38 children (<18 years) with pediatric cancer or Langerhans Cell Histiocytosis in New Zealand (June 2022-September 2023). Anthropometric, biochemical, and clinical data were collected at diagnosis and four follow-up points. Micronutrient abnormalities, including excesses and deficiencies, were highly prevalent, peaking at 3 months post-diagnosis (95%) and declining by month 12 (55%). Patients experienced reduced linear growth (p = .013) and increasing BMI over time (p = .03). Micronutrient status was significantly associated with malnutrition risk scores (SCAN and STRONGkids; p < .001), BMI-for-age z-scores, and weight status (BMI-for-age percentiles). Treatment complications were associated with micronutrient status (p < .001), weight status (p = .016), and malnutrition risk scores (p < .001). Nutritional challenges in pediatric cancer extend beyond weight changes to include micronutrient imbalances and clinical consequences. Routine nutritional assessment and targeted interventions, such as dietary optimization, micronutrient supplementation, and physical activity programs, are essential to improving treatment tolerance, recovery, and long-term health outcomes. FAU - Bertrand, Emilie AU - Bertrand E AD - The Department of Nutrition and Dietetics, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. FAU - Ross, Alexis AU - Ross A AD - The Department of Nutrition and Dietetics, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. AD - Starship Blood and Cancer Centre, Starship Child Health, Health New Zealand, Auckland, New Zealand. FAU - van den Heuvel, Eveline AU - van den Heuvel E AD - Starship Blood and Cancer Centre, Starship Child Health, Health New Zealand, Auckland, New Zealand. FAU - Wood, Andrew C AU - Wood AC AD - Starship Blood and Cancer Centre, Starship Child Health, Health New Zealand, Auckland, New Zealand. FAU - Lovell, Amy L AU - Lovell AL AD - The Department of Nutrition and Dietetics, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand. AD - Starship Blood and Cancer Centre, Starship Child Health, Health New Zealand, Auckland, New Zealand. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251201 PL - United States TA - Nutr Cancer JT - Nutrition and cancer JID - 7905040 RN - 0 (Micronutrients) SB - IM MH - Humans MH - Feasibility Studies MH - Male MH - Female MH - Child MH - *Neoplasms/complications/therapy MH - *Nutritional Status MH - Child, Preschool MH - Adolescent MH - Pilot Projects MH - *Malnutrition/epidemiology/etiology MH - Cohort Studies MH - New Zealand/epidemiology MH - Infant MH - Micronutrients/deficiency MH - Body Mass Index EDAT- 2025/12/02 07:36 MHDA- 2025/12/30 00:30 CRDT- 2025/12/02 03:02 PHST- 2025/12/30 00:30 [medline] PHST- 2025/12/02 07:36 [pubmed] PHST- 2025/12/02 03:02 [entrez] AID - 10.1080/01635581.2025.2576212 [doi] PST - ppublish SO - Nutr Cancer. 2026;78(2):111-122. doi: 10.1080/01635581.2025.2576212. Epub 2025 Dec 1. PMID- 41326957 OWN - NLM STAT- MEDLINE DCOM- 20260504 LR - 20260504 IS - 1532-5040 (Electronic) IS - 0959-3985 (Linking) VI - 42 IP - 5 DP - 2026 May TI - An examination of patient adherence and feasibility of different home-based exercise programs: a multicenter randomized controlled study. PG - 679-688 LID - 10.1080/09593985.2025.2596176 [doi] AB - BACKGROUND: Home-based exercise programs (HEPs) are critical for maintaining patient functionality after hospital discharge, yet a consensus on the most effective instruction method is lacking. PURPOSE: This study aims to examine the feasibility and patient adherence to different HEPs in adult and pediatric patients. METHODS: This multicenter, randomized controlled study included 237 adult and 60 pediatric patients. The adult group was given HEPs primarily consisting of strengthening exercises, while the pediatric group focused on stretching. Patients were randomized into one of three groups: verbal instruction only, verbal instruction together with a brochure, and verbal instruction together with a video. Participants and caregivers were evaluated using standardized tools such as the Functional Independence Measure (FIM) or Functional Independence Measure for Children (WeeFIM), the Fatigue Severity Scale (FSS), the State-Trait Anxiety Inventory (STAI), the Visual Analog Scale (VAS), and the Gross Motor Function Classification System (GMFCS). Exercise adherence was measured by the level of confidence in performing the exercises, and exercise feasibility was measured by the number of days exercised and exercise completion percentage. RESULTS: The mean age was 41.50 +/- 16.84 years for adults and 12.87 +/- 3.92 years for children. No significant difference was observed among the exercise learning types in the adult group (exercise confidence level: p = .936, eta(2) = 0.001; number of days exercised: p = .987, eta(2) = 0.001; exercise completion: p = .942, Cramer's V = 0.108). Similarly, no significant difference was found in the pediatric group (exercise confidence level: p = .536, eta(2) = 0.200; number of days exercised: p = .266, eta(2) = 0.045; exercise completion: p = .342, Cramer's V = 0.194). Furthermore, no significant difference in adherence was found between the age groups. CONCLUSION: This study suggests that the method of providing HEPs does not significantly impact adherence in either adult or pediatric patient populations. This finding indicates that video-based instruction is not superior to traditional methods like verbal instruction or brochures in improving exercise adherence. FAU - Altuntas Yilmaz, Neslihan AU - Altuntas Yilmaz N AUID- ORCID: 0000-0003-0116-9089 AD - Institute of Health Sciences, Department of Physiotherapy and Rehabilitation, Necmettin Erbakan University, Konya, Turkiye. FAU - Karademir, Mustafa AU - Karademir M AUID- ORCID: 0009-0000-6915-9157 AD - Institute of Health Sciences, Department of Physiotherapy and Rehabilitation, Necmettin Erbakan University, Konya, Turkiye. FAU - Ozkan, Yavuz AU - Ozkan Y AUID- ORCID: 0009-0006-6520-871X AD - Institute of Health Sciences, Department of Physiotherapy and Rehabilitation, Necmettin Erbakan University, Konya, Turkiye. FAU - Dagbasi, Abdulkadir AU - Dagbasi A AUID- ORCID: 0009-0008-3930-4980 AD - Institute of Health Sciences, Department of Physiotherapy and Rehabilitation, Necmettin Erbakan University, Konya, Turkiye. LA - eng PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20251201 PL - England TA - Physiother Theory Pract JT - Physiotherapy theory and practice JID - 9015520 SB - IM MH - Humans MH - Male MH - Female MH - Feasibility Studies MH - *Patient Compliance MH - Adult MH - *Exercise Therapy/methods MH - Middle Aged MH - Child MH - Adolescent MH - *Home Care Services MH - Young Adult MH - Aged MH - Patient Education as Topic/methods OTO - NOTNLM OT - Home-based exercise OT - feasibility OT - patient adherence OT - randomized controlled trials OT - teaching method EDAT- 2025/12/02 01:00 MHDA- 2026/05/04 12:35 CRDT- 2025/12/01 23:38 PHST- 2026/05/04 12:35 [medline] PHST- 2025/12/02 01:00 [pubmed] PHST- 2025/12/01 23:38 [entrez] AID - 10.1080/09593985.2025.2596176 [doi] PST - ppublish SO - Physiother Theory Pract. 2026 May;42(5):679-688. doi: 10.1080/09593985.2025.2596176. Epub 2025 Dec 1. PMID- 41326635 OWN - NLM STAT- MEDLINE DCOM- 20260108 LR - 20260111 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2025 Dec 1 TI - Influence of short video usage on adolescent's learning strategies: investigation on teenagers in HeBei North China. PG - 1050 LID - 10.1038/s41598-025-30713-y [doi] LID - 1050 AB - The proliferation of digital devices has led to increased screen time among adolescents, raising concerns about its impact on health, development, and academic performance. This study aimed to investigate the current state of digital screen time associated with short-videos among adolescents, analyze learning strategies across different demographic groups, and evaluate the influence of short-videos on adolescents' daily lives and learning strategies. A quantitative validation study was conducted with 4515 participants from 18 schools in HeBei province. Data were collected through a questionnaire that included demographic information, reasons for watching short-videos, and Zhang Yeheng's Learning Strategy Scale. Statistical analysis was performed using SPSSAU software, with non-parametric tests to compare groups. After removing invalid questionnaires, 3028 valid responses were analyzed. Middle school students scored higher in learning strategies than high school students. Participants who owned mobile phones and used these devices primarily on weekends had higher learning strategy scores. Conversely, increased daily screen time was associated with lower learning strategy scores. Short-video usage has a complex impact on adolescent learning strategies. While providing informational resources, excessive use may distract and impair learning outcomes. Collaborative efforts from families, schools, and society are needed to guide healthy short-video usage for adolescents' learning development. CI - (c) 2025. The Author(s). FAU - Ziye, Liu AU - Ziye L AD - Medical Technology College, HeBei Medical University, No.316 Zhong'shan E Rd, Shijiazhuang, 050017, HeBei, China. FAU - Yuying, Zhao AU - Yuying Z AD - Department of Cardiology, No.980 Hospital of PLA Joint Logistics Support Force, No.398 Zhong'shan W Rd, Shijiazhuang, 050082, HeBei, China. FAU - Ziyuan, Mao AU - Ziyuan M AD - Medical Technology College, HeBei Medical University, No.316 Zhong'shan E Rd, Shijiazhuang, 050017, HeBei, China. FAU - Zhimin, Han AU - Zhimin H AD - Academic Affairs Office, The Second Hospital of HeBei Medical University, No.215 Heping W Rd, Shijiazhuang, 050000, HeBei, China. hanzhimin2025@163.com. FAU - Xinhua, Li AU - Xinhua L AD - Medical Technology College, HeBei Medical University, No.316 Zhong'shan E Rd, Shijiazhuang, 050017, HeBei, China. LA - eng PT - Journal Article DEP - 20251201 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Adolescent MH - Male MH - Female MH - China MH - *Learning MH - Surveys and Questionnaires MH - Students/psychology MH - *Screen Time MH - *Adolescent Behavior/psychology MH - Schools PMC - PMC12783838 OTO - NOTNLM OT - Adolescent OT - Digital screen time OT - Learning strategies OT - Short-video usage COIS- Declarations. Competing interests: The authors have declared that no competing interests exist. Ethics Statement: The current study was approved by the Research Ethics Committee of the Second Hospital of HeBei Medical University (No.2024-R758). After obtaining consent from the guardian via telephone, the informed consent form was included in the surveylink. Participants who agreed to the informed consent continued to complete the questionnaire, while those who did not agree exited the survey link. EDAT- 2025/12/02 01:00 MHDA- 2026/01/09 00:26 PMCR- 2025/12/01 CRDT- 2025/12/01 23:29 PHST- 2025/07/27 00:00 [received] PHST- 2025/11/26 00:00 [accepted] PHST- 2026/01/09 00:26 [medline] PHST- 2025/12/02 01:00 [pubmed] PHST- 2025/12/01 23:29 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - 10.1038/s41598-025-30713-y [pii] AID - 30713 [pii] AID - 10.1038/s41598-025-30713-y [doi] PST - epublish SO - Sci Rep. 2025 Dec 1;16(1):1050. doi: 10.1038/s41598-025-30713-y. PMID- 41326443 OWN - NLM STAT- MEDLINE DCOM- 20251201 LR - 20260911 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Dec 1 TI - Development and validation of peaters choice, an intervention module for healthcare practitioners in managing picky eating among children aged 3-5 years. PG - 42878 LID - 10.1038/s41598-025-26949-3 [doi] LID - 42878 AB - Picky eating (PE) during early childhood is a growing concern, often linked to poor dietary intake and increased parental stress. While healthcare professionals (HCPs) are well-positioned to assist, there remains a lack of structured, evidence-based modules to guide PE management in public health settings. This research aim to develop a validated healthy eating intervention module for HCPs in managing picky eaters (PEaters Choice). The module development followed the first three phases of the ADDIE instructional design model: Analysis, Design, and Development. Phase 1 (Analysis) involved a scoping review, a quantitative, and qualitative study, while Phase 2 (Design) focused on designing the module content and aligning activities with relevant theoretical frameworks. In Phase 3 (Development), nine experts evaluated the newly developed module using face and content validity forms. Findings from Phases 1 and 2 informed a multidisciplinary module design, guiding its objectives, content, and delivery based on evidence and stakeholder input. In general, the PEaters Choice module surpassed established benchmarks, achieving high validity scores (> 80%) and S-CVI/Ave (> 0.80). Face validity results also confirmed the module's relevance, clarity of instruction, and alignment with its intended objectives of empowering HCPs to effectively manage pediatric PE in the public health setting. The PEaters Choice module demonstrates strong preliminary validity and offers a structured tool to assist HCPs in managing PE among children. While implementation and impact evaluation remain future steps, the current version provides a foundation for broader application and potential to empower both HCPs and parents. CI - (c) 2025. The Author(s). FAU - Kamarudin, Mohd Shah AU - Kamarudin MS AD - Faculty of Sports Science and Recreation, University Teknologi MARA Perlis, Arau, 02600, Malaysia. FAU - Hamzaid, Nur Hana AU - Hamzaid NH AD - Center for Rehabilitation & Special Need Studies (iCaRehab), Faculty of Health Sciences, Universiti Kebangsaan Malaysia Kuala Lumpur Campus, Kuala Lumpur, 50300, Malaysia. hanahamzaid@ukm.edu.my. FAU - Shahril, Mohd Razif AU - Shahril MR AD - Center for Healthy Ageing & Wellness (H-CARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia Kuala Lumpur Campus, Kuala Lumpur, 50300, Malaysia. FAU - Haron, Hasnah AU - Haron H AD - Center for Healthy Ageing & Wellness (H-CARE), Faculty of Health Sciences, Universiti Kebangsaan Malaysia Kuala Lumpur Campus, Kuala Lumpur, 50300, Malaysia. FAU - Kadar, Masne AU - Kadar M AD - Center for Rehabilitation & Special Need Studies (iCaRehab), Faculty of Health Sciences, Universiti Kebangsaan Malaysia Kuala Lumpur Campus, Kuala Lumpur, 50300, Malaysia. FAU - Safii, Nik Shanita AU - Safii NS AD - Center for Community Health Studies (ReaCH), Faculty of Health Sciences, Universiti Kebangsaan Malaysia Kuala Lumpur Campus, Kuala Lumpur, 50300, Malaysia. LA - eng GR - FRGS/1/2021/SKK06/UKM/03/3/Ministry of Higher Education, Malaysia/ GR - FRGS/1/2021/SKK06/UKM/03/3/Ministry of Higher Education, Malaysia/ GR - FRGS/1/2021/SKK06/UKM/03/3/Ministry of Higher Education, Malaysia/ GR - FRGS/1/2021/SKK06/UKM/03/3/Ministry of Higher Education, Malaysia/ GR - FRGS/1/2021/SKK06/UKM/03/3/Ministry of Higher Education, Malaysia/ GR - FRGS/1/2021/SKK06/UKM/03/3/Ministry of Higher Education, Malaysia/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251201 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Child, Preschool MH - *Health Personnel/education MH - Female MH - Male MH - *Food Preferences/psychology MH - *Feeding Behavior MH - *Choice Behavior MH - Diet, Healthy PMC - PMC12669771 OTO - NOTNLM OT - Education OT - Intervention module OT - Module development and validity module OT - Parenting OT - Picky eaters OT - Sensory COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/12/02 01:00 MHDA- 2025/12/02 01:01 PMCR- 2025/12/01 CRDT- 2025/12/01 23:20 PHST- 2024/06/10 00:00 [received] PHST- 2025/10/31 00:00 [accepted] PHST- 2025/12/02 01:01 [medline] PHST- 2025/12/02 01:00 [pubmed] PHST- 2025/12/01 23:20 [entrez] PHST- 2025/12/01 00:00 [pmc-release] AID - 10.1038/s41598-025-26949-3 [pii] AID - 26949 [pii] AID - 10.1038/s41598-025-26949-3 [doi] PST - epublish SO - Sci Rep. 2025 Dec 1;15(1):42878. doi: 10.1038/s41598-025-26949-3. PMID- 41326276 OWN - NLM STAT- MEDLINE DCOM- 20251201 LR - 20251201 IS - 1553-0205 (Electronic) IS - 1043-254X (Linking) VI - 99 IP - 6 DP - 2025 Dec TI - Examining Low-income Caregivers' Knowledge and Comprehension of the Dental Caries Process. PG - 29-39 AB - Purpose Dental caries among young children remains a public health concern in the United States (US). Children of caregivers with low oral health literacy (OHL) tend to have greater unmet dental needs and poorer oral health status. The purpose of this study was to examine the understanding of pediatric dental terms associated with the dental caries process among low-income caregivers.Methods This study included 14 caregivers with children enrolled in a Special Supplemental Nutrition Program for Women, Infants and Children (WIC) in the Southeastern US. Through structured phone interviews, the validated Oral Health Literacy Inventory for Parents (OH-LIP) was used to measure term recognition, vocabulary knowledge and comprehension of eight terms related to the dental caries process (i.e., acid, hidden sugars, plaque). Two researchers completed the scoring of the inventory and were calibrated on an adapted scoring guide. Content analysis and descriptive statistics were used for synthesizing responses on the OH-LIP inventory and a questionnaire, respectively.Results Term recognition (OH-LIP part I) scores were high with the majority of caregivers correctly pronouncing the 36 pediatric dental-related terms on the inventory. For the eight terms related to the dental caries process, vocabulary knowledge and comprehension (OH-LIP part II & III) scores were low to moderate, with 0 - 50% of participants providing a fully correct response. Furthermore, there was an observed decrease in scores for all eight terms related to the dental caries process from word recognition to comprehension.Conclusion This group of low-income caregivers had high word recognition scores for terms related to the dental caries process, indicating an initial high level of OHL. However, vocabulary knowledge and comprehension scores indicated minimal understanding of the same terms. These findings highlight the need for tailored oral health education and messaging that is easily understood for caregivers of young children. CI - Copyright (c) 2025 The American Dental Hygienists' Association. FAU - Sullivan, Melissa AU - Sullivan M AD - Gene W. Hirschfeld School of Dental Hygiene Old Dominion University Norfolk, VA, USA mlsulliv@odu.edu. FAU - McKinney, Denise C AU - McKinney DC AD - Gene W. Hirschfeld School of Dental Hygiene Old Dominion University Norfolk, VA, USA. FAU - Shuman, Deanne AU - Shuman D AD - Gene W. Hirschfeld School of Dental Hygiene Old Dominion University Norfolk, VA, USA. FAU - Zhang, Qi AU - Zhang Q AD - Joint School of Public Health Old Dominion University Norfolk, VA, USA. LA - eng PT - Journal Article PL - United States TA - J Dent Hyg JT - Journal of dental hygiene : JDH JID - 8902616 SB - IM MH - Humans MH - *Dental Caries/prevention & control MH - *Caregivers/psychology MH - Female MH - *Poverty MH - Male MH - *Health Literacy MH - *Comprehension MH - *Health Knowledge, Attitudes, Practice MH - Adult MH - Oral Health MH - Child, Preschool MH - Surveys and Questionnaires MH - Child MH - Middle Aged MH - Infant MH - Southeastern United States OTO - NOTNLM OT - WIC OT - caregivers OT - children OT - dental caries OT - oral health literacy OT - preventive behaviors EDAT- 2025/12/02 01:00 MHDA- 2025/12/02 01:01 CRDT- 2025/12/01 21:52 PHST- 2025/04/29 00:00 [received] PHST- 2025/08/12 00:00 [accepted] PHST- 2025/12/02 01:01 [medline] PHST- 2025/12/02 01:00 [pubmed] PHST- 2025/12/01 21:52 [entrez] AID - 99/6/29 [pii] PST - ppublish SO - J Dent Hyg. 2025 Dec;99(6):29-39. PMID- 41326038 OWN - NLM STAT- MEDLINE DCOM- 20251201 LR - 20251223 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 9 IP - 1 DP - 2025 Nov 30 TI - Association between maternal mental health and child nutritional status in rural Sindh: a cross-sectional study using an e-health clinical model. LID - 10.1136/bmjpo-2025-003972 [doi] LID - e003972 AB - OBJECTIVE: To assess the association between maternal common mental disorders (CMD), as measured by the Self-Reporting Questionnaire-20 (SRQ-20), and child nutritional outcomes wasting, stunting and underweight in rural Sindh, Pakistan, using an e-health clinical model. DESIGN: A cross-sectional observational study was conducted to explore the relationship between maternal mental health and child nutritional status. Data were collected through nurse-facilitated consultations at e-health clinics, with maternal CMD assessed via the WHO-validated SRQ-20 tool and child nutritional status measured using standardised anthropometric indicators (weight-for-height Z-score, height-for-age Z-score, weight-for-age Z-score) based on WHO growth standards. Multivariate logistic regression was applied to determine adjusted associations. SETTING: Six nurse-assisted e-health clinics operating under the Sehat Kahani telemedicine platform across rural regions of Sindh. PARTICIPANTS: A total of 455 mother-child dyads with children aged 6-59 months who visited clinics between April and June 2025. Eligible mothers had resided in the local area for 6 months and were not undergoing treatment for any mental health disorder. RESULTS: Stunting affected 62% of children, underweight 46.8% and wasting 43.3%. Maternal CMD was prevalent in 76.9% of participants (SRQ-20 score >/=7). Multivariate logistic regression revealed that children of mothers with CMD were about twice as likely to be stunted (adjusted odds ratio (AOR)=2.006, p=0.006) and nearly 1.6 times more likely to be underweight (AOR=1.688, p=0.05), though CMD showed no link with wasting. Maternal education was protective against stunting (AOR=0.458, p=0.012), while paternal unemployment was linked to increased odds of stunting and underweight. No significant associations were found with environmental factors, water source and toilet facilities. CONCLUSION: Maternal CMD, educational attainment and paternal employment status are key predictors of child nutritional status in rural, low-resource contexts. These findings underscore the need for integrated maternal mental health and child nutrition interventions within digital healthcare delivery models. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Muzzamil, Muhammad AU - Muzzamil M AUID- ORCID: 0000-0001-9871-5837 AD - Public Health and Digital Health, Sehat Kahani, Karachi, Sindh, Pakistan muzzamilrao21@gmail.com. AD - Public Health, Health Services Academy, Islamabad, Punjab, Pakistan. FAU - Khurram, Sara Saeed AU - Khurram SS AD - Public Health and Digital Health, Sehat Kahani, Karachi, Sindh, Pakistan. FAU - Aga, Iffat Zafar AU - Aga IZ AD - Public Health and Digital Health, Sehat Kahani, Karachi, Sindh, Pakistan. FAU - Karim, Mahek AU - Karim M AD - Public Health and Digital Health, Sehat Kahani, Karachi, Sindh, Pakistan. FAU - Fatima, Farwa AU - Fatima F AUID- ORCID: 0009-0003-8023-026X AD - Public Health, SZABIST, Karachi, Pakistan. FAU - Hashmi, Shahkamal AU - Hashmi S AD - College of Public Health, Ziauddin University, Karachi, Sindh, Pakistan. LA - eng PT - Journal Article PT - Observational Study DEP - 20251130 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Child, Preschool MH - *Nutritional Status MH - Infant MH - Rural Population/statistics & numerical data MH - Male MH - *Mental Disorders/epidemiology MH - Adult MH - Pakistan/epidemiology MH - *Mothers/psychology MH - *Growth Disorders/epidemiology MH - Telemedicine MH - *Maternal Health MH - *Child Nutrition Disorders/epidemiology MH - Thinness/epidemiology MH - *Mental Health PMC - PMC12684096 OTO - NOTNLM OT - Child Health OT - Developing Countries OT - Health services research OT - Low and Middle Income Countries OT - Noncommunicable Diseases COIS- Competing interests: No, there are no competing interests. EDAT- 2025/12/02 01:00 MHDA- 2025/12/02 01:01 PMCR- 2025/11/30 CRDT- 2025/12/01 20:52 PHST- 2025/08/11 00:00 [received] PHST- 2025/11/16 00:00 [accepted] PHST- 2025/12/02 01:01 [medline] PHST- 2025/12/02 01:00 [pubmed] PHST- 2025/12/01 20:52 [entrez] PHST- 2025/11/30 00:00 [pmc-release] AID - 10.1136/bmjpo-2025-003972 [pii] AID - bmjpo-2025-003972 [pii] AID - 10.1136/bmjpo-2025-003972 [doi] PST - epublish SO - BMJ Paediatr Open. 2025 Nov 30;9(1):e003972. doi: 10.1136/bmjpo-2025-003972. PMID- 41324936 OWN - NLM STAT- MEDLINE DCOM- 20260202 LR - 20260202 IS - 2168-6211 (Electronic) IS - 2168-6203 (Linking) VI - 180 IP - 2 DP - 2026 Feb 1 TI - Lifestyle Interventions Addressing Blood Pressure in Children: A Systematic Review. PG - 202-211 LID - 10.1001/jamapediatrics.2025.4943 [doi] AB - IMPORTANCE: The prevalence of high blood pressure in children is increasing, with health consequences reaching into adulthood. Individual-level interventions may help address the burden of high blood pressure at a population level, but there is less evidence from pediatric settings. OBJECTIVE: To assess the effectiveness of school- or community-based lifestyle interventions to reduce high blood pressure in children (aged 3-18 years) and identify components that support effectiveness. EVIDENCE REVIEW: Ovid MEDLINE, Embase, and PubMed were searched for studies from June 2013 to March 2024. Randomized clinical trials and quasi-experimental studies were assessed using the following strict inclusion criteria: longer than 6-month intervention duration, participants aged 3 to 18 years, major aim to modify cardiometabolic risk, and measurement of blood pressure before and after the intervention. Interventions aimed at specific patient groups were excluded. Quality assessment was performed using the Joanna Briggs Institute critical appraisal tools. Blood pressure before and after the intervention was extracted, with the mean difference in blood pressure recorded. Data analysis was performed from June 2023 to July 2024. FINDINGS: A total of 27 studies were included, of which 13 reported a beneficial effect on blood pressure; 24 studies targeted physical activity, 15 targeted nutrition, 16 targeted education, and 11 included family involvement. Of 14 multicomponent studies, 9 reported a beneficial effect on blood pressure. CONCLUSIONS AND RELEVANCE: In this systematic review, results indicate that lifestyle interventions can have a beneficial effect on blood pressure in the pediatric population, with multicomponent designs targeting both physical activity and nutrition showing the most promise. Future research should aim to further clarify intervention design and physical activity dosage, feasibility, and scalability, along with the long-term success of interventions that promote healthy blood pressure in children. FAU - Tiplady, Charlotte H AU - Tiplady CH AD - Melbourne Medical School, University of Melbourne, Melbourne, Victoria, Australia. FAU - Mynard, Jonathan P AU - Mynard JP AD - Heart Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia. AD - Department of Pediatrics, University of Melbourne, Melbourne, Victoria, Australia. AD - Department of Biomedical Engineering, University of Melbourne, Melbourne, Victoria, Australia. FAU - Vandeleur, Moya AU - Vandeleur M AD - Heart Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia. AD - Department of Pediatrics, University of Melbourne, Melbourne, Victoria, Australia. AD - Department of Respiratory and Sleep Medicine, Royal Children's Hospital, Parkville, Victoria, Australia. FAU - Ainkaran, Gyan AU - Ainkaran G AD - Melbourne Clinical School, The University of Notre Dame, Melbourne, Victoria, Australia. FAU - Li, Sherly X AU - Li SX AD - Heart Research, Murdoch Children's Research Institute, Parkville, Victoria, Australia. AD - Medical Research Council (MRC) Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom. FAU - Climie, Rachel AU - Climie R AD - Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia. FAU - Burgner, David P AU - Burgner DP AD - Department of Pediatrics, University of Melbourne, Melbourne, Victoria, Australia. AD - Inflammatory Origins Research Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia. FAU - Dwyer, Terence AU - Dwyer T AD - Clinical Sciences Theme, Heart Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia. AD - Nuffield Department of Women's and Reproductive Health, University of Oxford, Oxford, United Kingdom. AD - Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, Victoria, Australia. FAU - Quinlan, Catherine AU - Quinlan C AD - Department of Pediatrics, University of Melbourne, Melbourne, Victoria, Australia. FAU - Longmore, Danielle K AU - Longmore DK AD - Department of Pediatrics, University of Melbourne, Melbourne, Victoria, Australia. AD - Inflammatory Origins Research Group, Murdoch Children's Research Institute, Parkville, Victoria, Australia. AD - Department of Endocrinology and Diabetes, Royal Children's Hospital, Parkville, Victoria, Australia. LA - eng PT - Journal Article PT - Systematic Review PL - United States TA - JAMA Pediatr JT - JAMA pediatrics JID - 101589544 SB - IM MH - Humans MH - Child MH - *Hypertension/prevention & control/therapy MH - Adolescent MH - *Life Style MH - Child, Preschool MH - *Blood Pressure MH - Exercise EDAT- 2025/12/01 12:28 MHDA- 2026/02/03 00:00 CRDT- 2025/12/01 11:33 PHST- 2026/02/03 00:00 [medline] PHST- 2025/12/01 12:28 [pubmed] PHST- 2025/12/01 11:33 [entrez] AID - 2841558 [pii] AID - 10.1001/jamapediatrics.2025.4943 [doi] PST - ppublish SO - JAMA Pediatr. 2026 Feb 1;180(2):202-211. doi: 10.1001/jamapediatrics.2025.4943. PMID- 41324904 OWN - NLM STAT- MEDLINE DCOM- 20260624 LR - 20260729 IS - 1878-6324 (Electronic) IS - 1053-8127 (Linking) VI - 39 IP - 4 DP - 2026 Jul TI - Effectiveness of a telemonitoring injury prevention protocol on athletic performance in elite footballers: A randomized prospective controlled study. PG - 1216-1233 LID - 10.1177/10538127251400147 [doi] AB - BackgroundEmploying telecommunication systems and digital platforms, athletes can continuously access tailored injury prevention protocols, receive real-time feedback on exercise performance.ObjectiveThis study aimed to assess the feasibility, adherence, and benefits of a digitally administered adaptation of the FIFA 11 + protocol in professional football players.MethodsThis multicenter randomized prospective controlled study involved football players aged 15-40 from Italy and Switzerland, recruited between May 2023 and February 2024. Participants were randomly assigned to either the Intervention group (FIFA 11 + protocol administered digitally) or the Control group (traditional in-person FIFA 11 + protocol). Both groups performed the protocol twice a week for six months. Primary outcomes included the Illinois Agility Test, Slalom Dribbling Test, Multistage 20 m Shuttle Run Test (MSRT), and muscle strength tests for the hamstrings.ResultsFifty-five players participated: 27 in the Intervention group (mean age 20.63) and 28 in the Control group (mean age 20.25). Both groups showed significant improvements in hamstring strength, sprint performance, and MSRT outcomes (p < 0.05). No significant differences were observed between the groups in terms of strength, heart rate response, perceived exertion, or agility (p > 0.05).ConclusionFIFA 11 + protocol has been shown to be effective as the in-person version for improving physical performance and preventing injuries in football players. Further research is needed to explore this approach in broader settings. FAU - Lippi, Lorenzo AU - Lippi L AUID- ORCID: 0000-0001-9035-1485 AD - Department of Health Sciences, University of Eastern Piedmont "A. Avogadro", Novara, Italy. AD - Translational Medicine, Dipartimento Attivita Integrate Ricerca e Innovazione (DAIRI), Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy. FAU - de Sire, Alessandro AU - de Sire A AD - Department of Medical and Surgical Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy. AD - Research Center on Musculoskeletal Health, MusculoSkeletalHealth@UMG, University of Catanzaro "Magna Graecia", Catanzaro, Italy. FAU - Turco, Alessio AU - Turco A AD - Department of Health Sciences, University of Eastern Piedmont "A. Avogadro", Novara, Italy. FAU - Clemente, Federico AU - Clemente F AD - Department of Health Sciences, University of Eastern Piedmont "A. Avogadro", Novara, Italy. FAU - Cota, Andrea Brachet AU - Cota AB AD - Department of Scientific Research, Campus LUdeS, Off-Campus Semmelweis University of Budapest, Budapest, 1085, Hungary. FAU - Colombo, Riccardo AU - Colombo R AD - Department of Health Sciences, University of Eastern Piedmont "A. Avogadro", Novara, Italy. FAU - Sartorio, Francesco AU - Sartorio F AD - Department of Physical Medicine and Rehabilitation, Istituti Clinici Scientifici Maugeri IRCCS, Institute of Veruno, Gattico-Veruno, Italy. FAU - Ammendolia, Antonio AU - Ammendolia A AUID- ORCID: 0000-0002-2828-2455 AD - Department of Medical and Surgical Sciences, University of Catanzaro "Magna Graecia", Catanzaro, Italy. AD - Research Center on Musculoskeletal Health, MusculoSkeletalHealth@UMG, University of Catanzaro "Magna Graecia", Catanzaro, Italy. FAU - Longo, Umile Giuseppe AU - Longo UG AD - Fondazione Policlinico Universitario Campus Bio-Medico, Roma, Italy. AD - Research Unit of Orthopaedic and Trauma Surgery, Department of Medicine and Surgery, Universita Campus Bio- Medico di Roma, Roma, Italy. FAU - Invernizzi, Marco AU - Invernizzi M AD - Department of Health Sciences, University of Eastern Piedmont "A. Avogadro", Novara, Italy. AD - Translational Medicine, Dipartimento Attivita Integrate Ricerca e Innovazione (DAIRI), Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy. LA - eng PT - Journal Article PT - Multicenter Study PT - Randomized Controlled Trial DEP - 20251201 PL - United States TA - J Back Musculoskelet Rehabil JT - Journal of back and musculoskeletal rehabilitation JID - 9201340 SB - IM MH - Humans MH - Prospective Studies MH - Male MH - *Soccer/injuries MH - *Athletic Performance/physiology MH - *Athletic Injuries/prevention & control MH - Adult MH - Young Adult MH - Adolescent MH - Muscle Strength/physiology MH - Telemedicine MH - Italy MH - Switzerland OTO - NOTNLM OT - FIFA 11+ OT - exercise training OT - football OT - injury prevention OT - physical performance OT - rehabilitation OT - sports technology OT - tele-rehabilitation COIS- Declaration of conflicting interestsThe authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article. EDAT- 2025/12/01 12:27 MHDA- 2026/06/24 18:35 CRDT- 2025/12/01 11:23 PHST- 2026/06/24 18:35 [medline] PHST- 2025/12/01 12:27 [pubmed] PHST- 2025/12/01 11:23 [entrez] AID - 10.1177/10538127251400147 [doi] PST - ppublish SO - J Back Musculoskelet Rehabil. 2026 Jul;39(4):1216-1233. doi: 10.1177/10538127251400147. Epub 2025 Dec 1. PMID- 41324694 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20261010 IS - 1436-6215 (Electronic) IS - 1436-6207 (Linking) VI - 64 IP - 8 DP - 2025 Dec 1 TI - Development and validation of a multicriteria measure to assess the sustainability characteristics of diets: the Diet Sustainability Score. PG - 328 LID - 10.1007/s00394-025-03844-1 [doi] AB - PURPOSE: This cross-sectional study aims to develop and validate the Diet Sustainability Score (DSS), a multicriteria measure designed to evaluate the sustainability of diets by integrating nutritional, environmental, economic, and sociocultural dimensions. METHODS: Dietary data from 2287 adults (18 + years) who completed two non-consecutive 24-h dietary recalls during the National Food, Nutrition, and Physical Activity Survey (IAN-AF 2015/2016) were used to assess the psychometric properties of the DSS. Content validity was assessed through expert evaluation. Reproducibility was tested using the intraclass correlation coefficient (ICC), and construct validity was examined by testing conceptually derived hypotheses. RESULTS: The DSS demonstrated robust content validity through expert assessment and alignment with established frameworks. Reproducibility was supported by an ICC of 0.407 and construct validity by confirming 78% of conceptually derived hypotheses. The DSS showed positive associations with females, older ages, higher education, and higher income, as well as healthier lifestyle behaviours, including non-smoking, non-alcohol consumption, greater organic food intake, and less frequent eating out-of-home habits. Participants with higher DSS consumed more vegetables, fruits, fish, white meat, and olive oil and less red and processed meat, sweets, and salty snacks, aligning with Portuguese Mediterranean dietary guidelines. CONCLUSION: The DSS effectively captures the multidimensional nature of sustainable diets, offering a reliable tool for research and policy to promote more sustainable eating practices. FAU - Rei, Mariana AU - Rei M AUID- ORCID: 0000-0001-8945-3708 AD - Faculdade de Ciencias da Nutricao e Alimentacao, Universidade do Porto, Rua do Campo Alegre 823, 4150-180, Porto, Portugal. AD - EPIUnit - Instituto de Saude Publica, Universidade do Porto, 4050-600, Porto, Portugal. AD - Laboratorio para a Investigacao Integrativa e Translacional em Saude Populacional (ITR), Universidade do Porto, 4050-600, Porto, Portugal. AD - Faculdade de Medicina, Universidade do Porto, 4200-319, Porto, Portugal. FAU - Silva, Catarina Campos AU - Silva CC AUID- ORCID: 0009-0001-4146-9070 AD - Faculdade de Medicina, Universidade do Porto, 4200-319, Porto, Portugal. FAU - Torres, Duarte AU - Torres D AUID- ORCID: 0000-0001-8960-2160 AD - Faculdade de Ciencias da Nutricao e Alimentacao, Universidade do Porto, Rua do Campo Alegre 823, 4150-180, Porto, Portugal. AD - EPIUnit - Instituto de Saude Publica, Universidade do Porto, 4050-600, Porto, Portugal. AD - Laboratorio para a Investigacao Integrativa e Translacional em Saude Populacional (ITR), Universidade do Porto, 4050-600, Porto, Portugal. FAU - Sage, Colin AU - Sage C AUID- ORCID: 0000-0002-2063-4815 AD - Faculdade de Ciencias da Nutricao e Alimentacao, Universidade do Porto, Rua do Campo Alegre 823, 4150-180, Porto, Portugal. FAU - Rodrigues, Sara AU - Rodrigues S AUID- ORCID: 0000-0003-0647-5018 AD - Faculdade de Ciencias da Nutricao e Alimentacao, Universidade do Porto, Rua do Campo Alegre 823, 4150-180, Porto, Portugal. saraspr@fcna.up.pt. AD - EPIUnit - Instituto de Saude Publica, Universidade do Porto, 4050-600, Porto, Portugal. saraspr@fcna.up.pt. AD - Laboratorio para a Investigacao Integrativa e Translacional em Saude Populacional (ITR), Universidade do Porto, 4050-600, Porto, Portugal. saraspr@fcna.up.pt. LA - eng GR - 2021.04955.BD/FCT - Fundacao para a Ciencia e Tecnologia, I.P./ GR - https://doi.org/10.54499/LA/P/0064/2020/FCT - Fundacao para a Ciencia e Tecnologia, I.P./ GR - https://doi.org/10.54499/UIDB/04750/2020/FCT - Fundacao para a Ciencia e Tecnologia, I.P./ GR - PT06-000088SI3/EEA Grants Program, Public Health Initiatives/ PT - Journal Article PT - Validation Study DEP - 20251201 PL - Germany TA - Eur J Nutr JT - European journal of nutrition JID - 100888704 SB - IM MH - Humans MH - Female MH - Cross-Sectional Studies MH - Adult MH - Reproducibility of Results MH - Middle Aged MH - *Diet/statistics & numerical data/methods MH - Male MH - Young Adult MH - *Nutrition Surveys/methods MH - Psychometrics MH - *Diet Surveys/methods MH - Adolescent MH - Aged MH - Feeding Behavior MH - *Diet, Healthy/statistics & numerical data MH - Portugal OTO - NOTNLM OT - 24-h recalls OT - Adults OT - Dietary data OT - Multicriteria analysis OT - Sustainability score OT - Sustainable diets COIS- Declarations. Conflict of interest: The authors report that there are no competing interests to declare. Ethical approval: This research involved additional processing of previously collected personal data from the IAN-AF that had previously obtained ethical approval from the National Commission for Data Protection, the Ethical Committee of the Institute of Public Health of the University of Porto, and the Ethical Commissions of each of the Regional Administration of Health. All participants were asked to provide their written informed consent for participation according to the Ethical Principles for Medical Research involving human subjects expressed in the Declaration of Helsinki and the national legislation. Moreover, this study utilized a pseudo-anonymized database of IAN-AF. EDAT- 2025/12/01 12:29 MHDA- 2026/06/27 06:43 CRDT- 2025/12/01 11:16 PHST- 2025/06/26 00:00 [received] PHST- 2025/10/30 00:00 [accepted] PHST- 2026/06/27 06:43 [medline] PHST- 2025/12/01 12:29 [pubmed] PHST- 2025/12/01 11:16 [entrez] AID - 10.1007/s00394-025-03844-1 [pii] AID - 10.1007/s00394-025-03844-1 [doi] PST - epublish SO - Eur J Nutr. 2025 Dec 1;64(8):328. doi: 10.1007/s00394-025-03844-1. PMID- 41324000 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251201 LR - 20251203 IS - 2296-861X (Print) IS - 2296-861X (Electronic) IS - 2296-861X (Linking) VI - 12 DP - 2025 TI - Prognostic nutritional index as a predictor of in-hospital mortality in neonates and infants undergoing cardiac surgery. PG - 1686989 LID - 10.3389/fnut.2025.1686989 [doi] LID - 1686989 AB - OBJECTIVE: The prognostic nutritional index (PNI), combining nutritional and systemic inflammation markers is suggested as a predictor of negative outcomes post-cardiac surgery. This study investigated the link between PNI and in-hospital mortality in neonates and infants undergoing cardiac surgery. METHODS: This retrospective cohort study included 3,082 neonates and infants (aged 51.65).The association between PNI and in-hospital mortality was assessed using multivariable logistic regression models, adjusted for demographic, preoperative, and surgical variables. Subgroup analyses were performed to assess potential effect modification. The potential linear relationship between PNI and mortality was examined using generalized additive models and smooth curve fitting. RESULTS: The overall in-hospital mortality rate was 1.72% (53/3, 082). Patients with a PNI 51.65 (p < 0.001). Multivariable analysis identified PNI as an independent predictor of in-hospital mortality (adjusted odds ratio: 0.95; 95% CI: 0.91-0.98; p = 0.005). Subgroup analyses revealed significant effect modification by age, congenital heart disease (CHD) complexity, and cardiopulmonary bypass status (p for interaction < 0.05). The inverse relationship between PNI and mortality was stronger in neonates aged 30 days or younger, patients with non-complex CHD, and those undergoing off-pump surgery. Receiver operating characteristic analysis indicated that PNI effectively predicted in-hospital mortality, with an area under the curve of 0.745 (95% CI: 0.675-0.815; p < 0.001) and an optimal cutoff value of 51.65 determined by the Youden index. CONCLUSIONS: PNI independently predicts in-hospital mortality in neonates and infants undergoing cardiac surgery. The findings indicate that PNI could be an efficient tool for preoperative risk assessment in high-risk populations. CI - Copyright (c) 2025 Gu, Li, Huang, Bao, He, Li, Luo and Zhang. FAU - Gu, Xiaolin AU - Gu X AD - Department of Cardiac Surgical Intensive Care Unit, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. FAU - Li, Jie AU - Li J AD - Department of Cardiac Surgical Intensive Care Unit, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. FAU - Huang, Xiaoqin AU - Huang X AD - Department of Cardiac Surgical Intensive Care Unit, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. FAU - Bao, Rongxing AU - Bao R AD - Department of Cardiac Surgical Intensive Care Unit, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. FAU - He, Hailin AU - He H AD - Department of Cardiac Surgical Intensive Care Unit, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. FAU - Li, Liuyuan AU - Li L AD - Department of Cardiac Surgical Intensive Care Unit, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. FAU - Luo, Dandong AU - Luo D AD - Department of Cardiac Surgical Intensive Care Unit, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. FAU - Zhang, Chongjian AU - Zhang C AD - Department of Cardiac Surgical Intensive Care Unit, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. LA - eng PT - Journal Article DEP - 20251113 PL - Switzerland TA - Front Nutr JT - Frontiers in nutrition JID - 101642264 PMC - PMC12658984 OTO - NOTNLM OT - cardiac surgery OT - congenital heart disease OT - infants OT - mortality OT - neonates OT - prognostic nutritional index COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/01 12:29 MHDA- 2025/12/01 12:30 PMCR- 2025/11/13 CRDT- 2025/12/01 06:41 PHST- 2025/08/16 00:00 [received] PHST- 2025/10/24 00:00 [accepted] PHST- 2025/12/01 12:30 [medline] PHST- 2025/12/01 12:29 [pubmed] PHST- 2025/12/01 06:41 [entrez] PHST- 2025/11/13 00:00 [pmc-release] AID - 10.3389/fnut.2025.1686989 [doi] PST - epublish SO - Front Nutr. 2025 Nov 13;12:1686989. doi: 10.3389/fnut.2025.1686989. eCollection 2025. PMID- 41322661 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251201 LR - 20251203 IS - 2211-3355 (Print) IS - 2211-3355 (Electronic) IS - 2211-3355 (Linking) VI - 60 DP - 2025 Dec TI - Implementation of the whole school, whole community, whole child model in Makkah schools, Saudi Arabia: association with students' body mass index and academic achievement. PG - 103308 LID - 10.1016/j.pmedr.2025.103308 [doi] LID - 103308 AB - OBJECTIVE: To assess the implementation of the Whole School, Whole Community, Whole Child (WSCC) model in public elementary schools in Makkah, Saudi Arabia, and examine its association with students' body mass index (BMI) and academic achievement. METHODS: A cross-sectional study was conducted in 2022 across 20 elementary schools in Makkah using multistage cluster sampling. Participants included 385 students and 32 school staff from health-promoting schools (HPSs) and non-HPSs. Implementation of four WSCC domains; community involvement, family engagement, physical environment, and counseling services, was assessed using validated self-administered questionnaires. Academic scores, BMI, and sociodemographic data were collected. Data analysis utilized descriptive statistics, bivariate tests, Spearman correlations, and multivariable linear regression. RESULTS: Students in HPSs reported higher WSCC implementation and academic achievement than those in non-HPSs (median score: 687 vs. 665, p = 0.009). In multivariable models, WSCC implementation remained an independent predictor of academic achievement after adjustment (B = 1.63, 95 % CI: 0.90, 2.35), whereas its association with BMI was not significant (B = 0.36, 95 % CI: -0.32, 1.04). A dual burden of underweight and overweight was observed. CONCLUSIONS: Strengthening WSCC implementation, especially mental health support, family and community engagement, and equitable policy adoption, may enhance students' learning and well-being. CI - (c) 2025 Published by Elsevier Inc. FAU - Nour, Mohamed O AU - Nour MO AD - Department of Health Promotion and Education, College of Public Health & Health Informatics, Umm Al-Qura University, Makkah, Saudi Arabia. LA - eng PT - Journal Article DEP - 20251108 PL - United States TA - Prev Med Rep JT - Preventive medicine reports JID - 101643766 PMC - PMC12663021 OTO - NOTNLM OT - Academic achievement OT - BMI OT - Health-promoting school OT - Makkah OT - Non-health-promoting school OT - WSCC model COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/12/01 12:28 MHDA- 2025/12/01 12:29 PMCR- 2025/11/08 CRDT- 2025/12/01 06:27 PHST- 2025/08/21 00:00 [received] PHST- 2025/11/06 00:00 [revised] PHST- 2025/11/07 00:00 [accepted] PHST- 2025/12/01 12:29 [medline] PHST- 2025/12/01 12:28 [pubmed] PHST- 2025/12/01 06:27 [entrez] PHST- 2025/11/08 00:00 [pmc-release] AID - S2211-3355(25)00347-X [pii] AID - 103308 [pii] AID - 10.1016/j.pmedr.2025.103308 [doi] PST - epublish SO - Prev Med Rep. 2025 Nov 8;60:103308. doi: 10.1016/j.pmedr.2025.103308. eCollection 2025 Dec. PMID- 41322210 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251201 LR - 20251203 IS - 2296-858X (Print) IS - 2296-858X (Electronic) IS - 2296-858X (Linking) VI - 12 DP - 2025 TI - Optimizing myopia prediction in children and adolescents using machine learning: a multi-factorial risk assessment model. PG - 1672432 LID - 10.3389/fmed.2025.1672432 [doi] LID - 1672432 AB - BACKGROUND: Most previous studies on myopia in children and adolescents have primarily focused on genetic and environmental factors. This study aimed to explore modifiable behavioral, sociodemographic, and psychological contributors to myopia and to evaluate the potential of machine learning (ML) models in identifying at-risk individuals. METHODS: A cross-sectional survey was conducted in eight primary and secondary schools in a Chinese province between October and December 2023. The dataset was split into training and testing sets (7:3). LASSO regression identified potential predictors, followed by multivariate logistic regression to determine independent risk factors. Ten machine learning algorithms were used to build prediction models: logistic regression, support vector machine (SVM), gradient boosting machine (GBM), neural network (NNET), extreme gradient boosting (XGBoost), k-nearest neighbors (KNN), random forest adaptive boosting (AdaBoost), LightGBM, and CatBoost. Model performance was evaluated using accuracy, F1 score, specificity, sensitivity, and area under the receiver operating characteristic (ROC) curve (AUC). SHapley Additive exPlanations (SHAP) were used to interpret variable contributions in the best-performing model. RESULTS: The study included 2,086 children and adolescents (mean age 9.8 +/- 2.7 years; 50.5% female), with an overall myopia prevalence of 25.12%. Independent risk factors for myopia included parental myopia, only-child status, physical activity level, mother's education level, age, and physical activity behavior. Among all models, the LightGBM algorithm achieved the best predictive performance (AUC = 0.738, 95% CI: 0.709-0.767). SHAP analysis identified parental myopia, physical activity level, only-child status, and physical activity behavior as the most influential predictors. CONCLUSION: Although ML models showed limited predictive accuracy, they helped identify modifiable risk factors associated with childhood and adolescent myopia. These findings may inform the design of targeted prevention strategies and early behavioral interventions rather than serve as clinical diagnostic tools. CI - Copyright (c) 2025 Xi, Zhu, Yan, Wei, Zhao and Dai. FAU - Xi, Yue AU - Xi Y AD - School of Physical Education, Shanghai University, Shanghai, China. FAU - Zhu, Wei AU - Zhu W AD - Yinchuan Maternal and Child Health Hospital, Yinchuan, China. FAU - Yan, Wenjing AU - Yan W AD - School of Physical Education, Shanxi Normal University, Taiyuan, Shanxi, China. FAU - Wei, Xiaobin AU - Wei X AD - Division of Sports Science and Physical Education, Tsinghua University, Beijing, China. FAU - Zhao, Qian AU - Zhao Q AD - The No. 10 Primary School of Zhongning County, Zhongwei, China. FAU - Dai, Shengting AU - Dai S AD - School of Sports Science and Engineering, East China University of Science and Technology, Shanghai, China. LA - eng PT - Journal Article DEP - 20251113 PL - Switzerland TA - Front Med (Lausanne) JT - Frontiers in medicine JID - 101648047 PMC - PMC12657413 OTO - NOTNLM OT - LightGBM OT - children and adolescents OT - machine learning OT - modifiable risk factors OT - myopia COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/01 12:27 MHDA- 2025/12/01 12:28 PMCR- 2025/11/13 CRDT- 2025/12/01 06:23 PHST- 2025/08/11 00:00 [received] PHST- 2025/10/20 00:00 [accepted] PHST- 2025/12/01 12:28 [medline] PHST- 2025/12/01 12:27 [pubmed] PHST- 2025/12/01 06:23 [entrez] PHST- 2025/11/13 00:00 [pmc-release] AID - 10.3389/fmed.2025.1672432 [doi] PST - epublish SO - Front Med (Lausanne). 2025 Nov 13;12:1672432. doi: 10.3389/fmed.2025.1672432. eCollection 2025. PMID- 41321457 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251201 LR - 20251203 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 13 DP - 2025 TI - Attending a one-to-one child-centered movement therapy program improves multiple outcomes among children with neurodevelopmental disabilities: an exploratory prospective cohort study. PG - 1623686 LID - 10.3389/fped.2025.1623686 [doi] LID - 1623686 AB - INTRODUCTION: Children with neurodevelopmental and/or intellectual disabilities/disorders (NDID) often face barriers that limit their participation in typical school and community activities alongside their peers. Adapted, community-based physical activity programs may help bridge this gap by offering safe and engaging environments that promote integration, socialization, and learning. This study aimed to evaluate the potential effects of the Empowering Steps Movement Therapy (ESMT) one-to-one personalized physical activity program on children and youth with NDID. METHOD: A prospective cohort study was conducted to collect information regarding the changes in participants' motor skills (measured by BOT-2-SF), social and leisure adaptive skills (measured by ABAS-II), community and home participation (measured by PEM-CY), and quality of life (measured by KIDSCREEN-27). Forty-two children and youth with NDID attending the ESMT program were followed for 12 months with follow-up every 3 months. A linear mixed-effects (LME) model was used to analyze longitudinal changes, as well as studying the influence of children's and families' baseline characteristics on the outcomes. RESULTS: For motor skills, children showed a small but consistent positive trend in standardized motor skills (BOT-2-SF) over time, averaging 0.17 points per month (95% CI: -0.01 to 0.34; p = 0.06), with a slightly higher gain among autistic children (0.20 points; 95% CI: -0.03 to 0.43; p = 0.08). Positive trends were also observed in home and community participation. However, improvements were minimal for social adaptive skills, and a slight decline was noted in leisure adaptive skills and quality of life. Several potential confounders including parental education, socioeconomic status, and participation in other community-based programs were examined, indicating that some may play a significant role. Notably, the type of underlying condition contributing to neurodevelopmental disability appeared to be an important effect modifier for both motor skills and social adaptive skills. CONCLUSION: Despite the small sample size, this study suggests that individualized, one-to-one physical activity programs which provide individualized scaffolding tailored to each child's unique needs, may yield meaningful improvements across multiple domains in children with NDID. Larger studies are warranted to validate these findings and further support the adoption of personalized, socially engaging approaches in therapeutic physical activity settings. CI - (c) 2025 Gitimoghaddam, McKellin, Olsen, Miller, Symington and Collet. FAU - Gitimoghaddam, Mojgan AU - Gitimoghaddam M AD - Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada. AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. FAU - McKellin, William H AU - McKellin WH AD - Department of Anthropology, University of British Columbia, Vancouver, BC, Canada. FAU - Olsen, Lise AU - Olsen L AD - School of Nursing, University of British Columbia, Okanagan, BC, Canada. FAU - Miller, Anton R AU - Miller AR AD - Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada. AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. FAU - Symington, Vivien AU - Symington V AD - Club Aviva Recreation Ltd., Coquitlam, BC, Canada. FAU - Collet, Jean-Paul AU - Collet JP AD - Department of Pediatrics, University of British Columbia, Vancouver, BC, Canada. AD - BC Children's Hospital Research Institute, Vancouver, BC, Canada. LA - eng PT - Journal Article DEP - 20251113 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC12658744 OTO - NOTNLM OT - autism OT - child development OT - children OT - motor skill OT - neurodevelopmental disability OT - personalized approach OT - physical activity OT - scaffolding COIS- The study was conducted by the University of British Columbia in total scientific independence of the ESMT program. J-PC, WM and PhD student MG developed the protocol, received ethics approval and collected information without receiving help from the ESMT program. The article has been developed by the investigators. VS is the director and founder of the Empowering Steps Movement Therapy (ESMT) program owned by Symington Teaching Programs and delivered at Club Aviva Recreation Ltd. where the study was conducted. She is involved as a co-author for her specific expertise but did not play any decisional role regarding the publication. MG received an honorarium from Club Aviva in year 2022 as a token of appreciation for her assistance with the scoping review conducted by Club Aviva which was independent of this project. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/12/01 12:28 MHDA- 2025/12/01 12:29 PMCR- 2025/11/13 CRDT- 2025/12/01 06:16 PHST- 2025/07/04 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2025/12/01 12:29 [medline] PHST- 2025/12/01 12:28 [pubmed] PHST- 2025/12/01 06:16 [entrez] PHST- 2025/11/13 00:00 [pmc-release] AID - 10.3389/fped.2025.1623686 [doi] PST - epublish SO - Front Pediatr. 2025 Nov 13;13:1623686. doi: 10.3389/fped.2025.1623686. eCollection 2025. PMID- 41320986 OWN - NLM STAT- MEDLINE DCOM- 20251201 LR - 20251222 IS - 1743-8942 (Electronic) IS - 0167-482X (Linking) VI - 46 IP - 1 DP - 2025 Dec 31 TI - Exploring the relationship between breastfeeding and psychological well-being after traumatic childbirth: a secondary analysis of the PERCEIVE study data. PG - 2588223 LID - 10.1080/0167482X.2025.2588223 [doi] AB - BACKGROUND: The relation between maternal mental health and breastfeeding is complex, with breastfeeding often associated with improved well-being. OBJECTIVE: This study investigates associations between breastfeeding outcomes and psychological well-being in women with traumatic birth experience (TBE). METHODS: This exploratory secondary analysis utilized data from the PERCEIVE randomized controlled trial, which assessed the effectiveness of early eye movement desensitization and reprocessing (EMDR) therapy on posttraumatic stress disorder (PTSD) symptoms after TBE. Women with self-reported TBE (n = 143) were recruited between 2020 and 2023 from a hospital and midwifery practices in the Netherlands. Breastfeeding status was assessed at two (T0) and nine (T1) weeks postpartum. Outcomes were assessed using validated questionnaires on mother‒infant bonding (PBQ), PTSD symptoms (PCL-5), depression (EPDS), fear of childbirth (W-DEQ-B), and quality of life (WHOQOL-BREF). RESULTS: Among 143 participants, 126 initiated breastfeeding. At T0, breastfeeding women reported fewer symptoms of mother‒infant bonding difficulties, compared with non-breastfeeding women, p = 0.004. At T1, descriptive analyses found that participants who stopped breastfeeding reported more PTSD and depression symptoms. CONCLUSIONS: Our findings suggest that breastfeeding enhances mother-infant bonding after TBE. The weaker bonding reported in nonbreastfeeding participants, coupled with possible poorer mental health outcomes, underscores the need for targeted interventions to support breastfeeding and bonding in this population. FAU - Manshanden, Theresia Margaretha Nicole AU - Manshanden TMN AD - Department of Obstetrics and Gynecology, OLVG, Amsterdam, The Netherlands. AD - Athena Institute, Faculty of Science, VU University, Amsterdam, The Netherlands. AD - Department of Obstetrics & Gynecology, Northwest Clinics, Alkmaar, The Netherlands. FAU - Hendrix, Y M G A AU - Hendrix YMGA AD - Department of Obstetrics and Gynecology, OLVG, Amsterdam, The Netherlands. FAU - Scheele, Fedde AU - Scheele F AD - Athena Institute, Faculty of Science, VU University, Amsterdam, The Netherlands. FAU - Velzel, Joost AU - Velzel J AD - Department of Obstetrics & Gynecology, Northwest Clinics, Alkmaar, The Netherlands. FAU - van Pampus, Marielle G AU - van Pampus MG AD - Department of Obstetrics and Gynecology, OLVG, Amsterdam, The Netherlands. LA - eng PT - Journal Article PT - Randomized Controlled Trial DEP - 20251130 PL - England TA - J Psychosom Obstet Gynaecol JT - Journal of psychosomatic obstetrics and gynaecology JID - 8308648 SB - IM MH - Adult MH - Female MH - Humans MH - Pregnancy MH - *Breast Feeding/psychology/statistics & numerical data MH - Eye Movement Desensitization Reprocessing MH - *Mother-Child Relations/psychology MH - *Mothers/psychology MH - Netherlands MH - *Object Attachment MH - *Parturition/psychology MH - Psychological Well-Being MH - Quality of Life/psychology MH - *Stress Disorders, Post-Traumatic/therapy/psychology MH - Secondary Data Analysis OTO - NOTNLM OT - Psychological well-being OT - breastfeeding OT - postpartum OT - traumatic childbirth EDAT- 2025/12/01 06:25 MHDA- 2025/12/01 06:26 CRDT- 2025/12/01 02:02 PHST- 2025/12/01 06:26 [medline] PHST- 2025/12/01 06:25 [pubmed] PHST- 2025/12/01 02:02 [entrez] AID - 10.1080/0167482X.2025.2588223 [doi] PST - ppublish SO - J Psychosom Obstet Gynaecol. 2025 Dec 31;46(1):2588223. doi: 10.1080/0167482X.2025.2588223. Epub 2025 Nov 30. PMID- 41320165 OWN - NLM STAT- MEDLINE DCOM- 20260201 LR - 20260201 IS - 1678-4782 (Electronic) IS - 0021-7557 (Print) IS - 0021-7557 (Linking) VI - 102 IP - 1 DP - 2026 Jan-Feb TI - Clinical characteristics and gaps in palliative care among tracheostomized children: a retrospective observational study. PG - 101480 LID - S0021-7557(25)00168-8 [pii] LID - 10.1016/j.jped.2025.101480 [doi] LID - 101480 AB - OBJECTIVE: To describe the clinical characteristics of tracheostomized children in Northeastern Brazil and to identify existing gaps in the indication and implementation of palliative care. METHODS: This retrospective descriptive study reviewed medical records of children under 15 years who underwent tracheostomy between 2008 and 2019 at a quaternary referral center. RESULTS: Sixty-five tracheostomized patients with indications for palliative care were analyzed. The main reasons for palliative classification were acute life-threatening conditions (50.7 %) and chronic life-threatening conditions (20 %). The most frequent tracheostomy indications were prolonged invasive mechanical ventilation (46.1 %) and severe upper airway obstruction (23 %). The mortality rate was 30.7 %, higher among infants, severely malnourished children, those with Lansky scores below 40 % before tracheostomy, congenital heart disease, bronchopulmonary dysplasia, and multiple comorbidities. Only 10.8 % received palliative care consultations during hospitalization, all in the end-of-life care phase. CONCLUSIONS: The results highlight a critical gap in the provision of palliative care to tracheostomized children. Early involvement of a multidisciplinary palliative care team is crucial to support clinical decision-making, family-centered care, and ensure quality of life. The proposed framework may facilitate timely referral and airway planning in the Intensive therapy, although further validation and qualitative research in various healthcare settings are needed. CI - Copyright (c) 2025 The Authors. Published by Elsevier Espana S.L.U. All rights reserved. FAU - Luna, Luziane Lais Sabino Silva AU - Luna LLSS AD - Instituto de Medicina Integral Prof. Fernando Figueira - IMIP, Recife, PE, Brazil. Electronic address: luziane.sabino@gmail.com. FAU - Duarte, Maria do Carmo Menezes Bezerra AU - Duarte MDCMB AD - Instituto de Medicina Integral Prof. Fernando Figueira - IMIP, Recife, PE, Brazil. FAU - Levy, Sheyla Suelle Dos Santos AU - Levy SSDS AD - Instituto de Medicina Integral Prof. Fernando Figueira - IMIP, Recife, PE, Brazil. FAU - Lima, Luciana Santana AU - Lima LS AD - Instituto de Medicina Integral Prof. Fernando Figueira - IMIP, Recife, PE, Brazil. LA - eng PT - Journal Article PT - Observational Study DEP - 20251212 PL - Brazil TA - J Pediatr (Rio J) JT - Jornal de pediatria JID - 2985188R SB - IM MH - Humans MH - *Palliative Care/statistics & numerical data MH - Retrospective Studies MH - *Tracheostomy/statistics & numerical data/mortality MH - Infant MH - Child, Preschool MH - Male MH - Child MH - Female MH - Brazil MH - Adolescent MH - Infant, Newborn MH - Quality of Life PMC - PMC12765322 OTO - NOTNLM OT - Children OT - Palliative care OT - Tracheostomy COIS- Conflicts of interest The authors declare no conflicts of interest. EDAT- 2025/12/01 00:30 MHDA- 2026/02/02 00:29 PMCR- 2025/12/12 CRDT- 2025/11/30 19:20 PHST- 2025/07/10 00:00 [received] PHST- 2025/10/31 00:00 [revised] PHST- 2025/10/31 00:00 [accepted] PHST- 2026/02/02 00:29 [medline] PHST- 2025/12/01 00:30 [pubmed] PHST- 2025/11/30 19:20 [entrez] PHST- 2025/12/12 00:00 [pmc-release] AID - S0021-7557(25)00168-8 [pii] AID - 101480 [pii] AID - 10.1016/j.jped.2025.101480 [doi] PST - ppublish SO - J Pediatr (Rio J). 2026 Jan-Feb;102(1):101480. doi: 10.1016/j.jped.2025.101480. Epub 2025 Dec 12. PMID- 41319348 OWN - NLM STAT- MEDLINE DCOM- 20251211 LR - 20251211 IS - 1879-0739 (Electronic) IS - 0271-5317 (Linking) VI - 144 DP - 2025 Dec TI - Evening chronotype, irregular circadian eating patterns, and eating-related behaviors may be associated with increased obesity risk among Turkish university students: A large-scale cross-sectional study. PG - 74-87 LID - S0271-5317(25)00136-8 [pii] LID - 10.1016/j.nutres.2025.11.002 [doi] AB - This study investigated the interplay between chronotype, chrononutritional indices, diet quality, eating behaviors, circadian rhythm variables, and obesity indicators in university students. Specifically, in this cross-sectional study, 618 healthy students from Erciyes University completed validated questionnaires assessing chronotype (Morningness-Eveningness Questionnaire, MEQ), Mediterranean diet adherence (Mediterranean Diet Adherence Screener, MEDAS), hedonic hunger (Power of Food Scale, PFS), eating awareness (Mindful Eating Inventory, MEI), and chrononutritional variables. Furthermore, associations were evaluated using ANCOVA, partial correlations, and multiple regression analyses. Results indicated that morning types demonstrated higher MEDAS and MEI scores, more frequent breakfast consumption, lower eating and social jetlag than evening types; while evening types had a shorter eating window than intermediate types (all P < .05). Moreover, greater eating jetlag was associated with longer eating windows, more frequent breakfast consumption, higher social jetlag, and shorter sleep (all P < .001). In addition, multivariable models showed that MEI scores were inversely associated with waist circumference (beta = -0.104, P < .001), waist-to-hip ratio (beta = -0.074, P = .013), and body mass index (beta = -0.156, P < .001). Conversely, PFS scores were positively correlated with anthropometric indicators of obesity, while MEI scores were inversely associated with these measures (all P < .05). Taken together, evening chronotype, irregular meal timing, and predominantly lower eating awareness were independently linked to poorer dietary patterns, adverse eating behaviors, and increased obesity risk in young adults. Thus, promoting morning-oriented eating, regular meals, and mindful eating may improve metabolic health in this population. CI - Copyright (c) 2025 Elsevier Inc. All rights reserved. FAU - Ilkay, Hatice Ozcaliskan AU - Ilkay HO AD - Department of Nutrition and Dietetics, Faculty of Health Sciences, Erciyes University, Melikgazi, Kayseri, Turkey. Electronic address: ozcaliskan@erciyes.edu.tr. LA - eng PT - Journal Article DEP - 20251105 PL - United States TA - Nutr Res JT - Nutrition research (New York, N.Y.) JID - 8303331 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Male MH - *Feeding Behavior MH - *Circadian Rhythm MH - *Obesity/etiology/epidemiology MH - *Students MH - Universities MH - Young Adult MH - Turkey/epidemiology MH - Adult MH - Surveys and Questionnaires MH - Diet, Mediterranean MH - Sleep MH - Waist Circumference MH - Breakfast MH - Risk Factors MH - Diet MH - Body Mass Index MH - Hunger MH - Adolescent MH - Chronotype OTO - NOTNLM OT - Chrononutrition OT - Chronotype OT - Eating behavior OT - Hedonic hunger OT - Mindful eating OT - Obesity OT - Young adults COIS- Author declarations None. EDAT- 2025/11/30 19:31 MHDA- 2025/12/12 03:28 CRDT- 2025/11/30 17:59 PHST- 2025/08/27 00:00 [received] PHST- 2025/11/03 00:00 [revised] PHST- 2025/11/03 00:00 [accepted] PHST- 2025/12/12 03:28 [medline] PHST- 2025/11/30 19:31 [pubmed] PHST- 2025/11/30 17:59 [entrez] AID - S0271-5317(25)00136-8 [pii] AID - 10.1016/j.nutres.2025.11.002 [doi] PST - ppublish SO - Nutr Res. 2025 Dec;144:74-87. doi: 10.1016/j.nutres.2025.11.002. Epub 2025 Nov 5. PMID- 41318965 OWN - NLM STAT- MEDLINE DCOM- 20260202 LR - 20260205 IS - 1536-4801 (Electronic) IS - 0277-2116 (Print) IS - 0277-2116 (Linking) VI - 82 IP - 2 DP - 2026 Feb TI - Using machine learning to predict clinical remission with exclusive enteral nutrition in pediatric Crohn disease. PG - 465-476 LID - 10.1002/jpn3.70299 [doi] AB - OBJECTIVES: Exclusive enteral nutrition (EEN) is a first-line treatment for induction of remission in luminal pediatric Crohn disease (pCD). However, as the efficacy of EEN varies from patient to patient, there is a need to distinguish between responders and nonresponding patients. This study had two aims. First, to develop a model to predict EEN-induced clinical remission (weighted pediatric CD activity index [wPCDA] /=36 weeks after EEN). METHODS: We applied machine learning to clinical and laboratory data from a prospectively followed cohort of pCD patients who received EEN as their first treatment for CD (n = 308). This learning algorithm used feature selection and k-fold (internal) cross-validation to systematically find the model with the best combination of features and hyperparameter settings. To estimate the quality of the learned model, we used k-fold (external) cross-validation. RESULTS: Clinical, laboratory, and treatment data were compiled into two different datasets: EEN clinical remission at the end of EEN treatment (mean of 60 days; n = 114) and corticosteroid-free sustained clinical remission post-EEN induction (n = 206). Our resulting models were effective, with external area under the curves of 0.65 +/- 0.015 and 0.60 +/- 0.018. Moreover, a permutation label test showed that our learning process was stable and significantly different from chance, at p-values of 0.002 and 0.01, respectively. CONCLUSION: Our models, based on accessible clinical features, were able to effectively predict EEN success above chance. This supports the plausibility of building clinical tools to assist precision therapy for pCD patients. CI - (c) 2025 The Author(s). Journal of Pediatric Gastroenterology and Nutrition published by Wiley Periodicals LLC on behalf of European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition. FAU - Suarez, Ricardo G Suarez AU - Suarez RGS AUID- ORCID: 0000-0003-2609-7894 AD - Department of Paediatrics, University of Alberta, Edmonton, Alberta, Canada. FAU - McClement, Daniel G AU - McClement DG AD - Department of Paediatrics, University of Alberta, Edmonton, Alberta, Canada. FAU - Vega, Roberto AU - Vega R AD - Department of Computing Science, University of Alberta, Edmonton, Alberta, Canada. FAU - Huynh, Hien Q AU - Huynh HQ AD - Department of Paediatrics, University of Alberta, Edmonton, Alberta, Canada. FAU - Shaikh, Ayub AU - Shaikh A AD - SickKids Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children (SickKids), Toronto, Ontario, Canada. FAU - Otley, Anthony AU - Otley A AD - Department of Pediatrics, Division of Gastroenterology, Dalhousie University, Halifax, Nova Scotia, Canada. FAU - Jacobson, Kevan AU - Jacobson K AD - Department of Paediatrics, Division of Gastroenterology, Hepatology and Nutrition, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. FAU - Sherlock, Mary AU - Sherlock M AD - Division of Paediatrics, Faculty of Health Sciences McMaster University, Hamilton, Ontario, Canada. FAU - Mack, David R AU - Mack DR AD - Department of Pediatrics, Children's Hospital of Eastern Ontario and University of Ottawa, Ottawa, Ontario, Canada. FAU - Deslandres, Colette AU - Deslandres C AD - Department of Paediatrics, Division of Gastroenterology, Hepatology and Nutrition, CHU Sainte-Justine, Universite de Montreal, Montreal, Quebec, Canada. FAU - El-Matary, Wael AU - El-Matary W AD - Department of Paediatrics, Max Rady College of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. FAU - Crowley, Eileen AU - Crowley E AD - Department of Paediatrics, Children Hospital of Western Ontario, Western University, London, Ontario, Canada. FAU - deBruyn, Jennifer AU - deBruyn J AD - Department of Paediatrics, Cumming School of Medicine University of Calgary, Calgary, Alberta, Canada. FAU - Walters, Thomas AU - Walters T AD - SickKids Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children (SickKids), Toronto, Ontario, Canada. FAU - Griffiths, Anne M AU - Griffiths AM AD - SickKids Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children (SickKids), Toronto, Ontario, Canada. FAU - Greiner, Russell AU - Greiner R AUID- ORCID: 0000-0001-8327-934X AD - Department of Computing Science, University of Alberta, Edmonton, Alberta, Canada. FAU - Eytan Wine AU - Eytan Wine AUID- ORCID: 0000-0002-3458-4142 AD - Department of Paediatrics, University of Alberta, Edmonton, Alberta, Canada. AD - SickKids Inflammatory Bowel Disease Centre, Division of Gastroenterology, Hepatology and Nutrition, The Hospital for Sick Children (SickKids), Toronto, Ontario, Canada. AD - Department of Physiology, University of Alberta, Edmonton, Alberta, Canada. CN - Canadian Children IBD Network LA - eng GR - 426160/Canadian Institutes of Health Research (CIHR)/ GR - Children with Intestinal and Liver Disorders (Ch.I.L.D.) Foundation/ GR - The Canadian Children Inflammatory Bowel Disease Network (CIDsCaNN)/ GR - Women & Children's Health Research Institute (WCHRI)/ PT - Journal Article DEP - 20251129 PL - United States TA - J Pediatr Gastroenterol Nutr JT - Journal of pediatric gastroenterology and nutrition JID - 8211545 RN - Pediatric Crohn's disease SB - IM MH - Humans MH - *Crohn Disease/therapy MH - *Enteral Nutrition/methods MH - *Machine Learning MH - Remission Induction MH - Child MH - Male MH - Female MH - Adolescent MH - Prospective Studies MH - Treatment Outcome PMC - PMC12864170 OTO - NOTNLM OT - classification task OT - model selecting learner OT - nutritional therapy OT - personalized medicine OT - treatment response COIS- Hien Q. Huynh has had previous research funding and speaker fees from Janssen, AbbVie, and Takada. Has been on the board for AbbVie. Anthony Otley has served on the advisory board for AbbVie Canada, Janssen Canada, and Amgen; he has received unrestricted educational grants from AbbVie Canada; his site is involved with clinical trials for AbbVie, Pfizer, Takeda, Eli Lily, and BMS; and he is co-owner of the copyright for Pediatric Ulcerative Colitis Activity Index and the IMPACT questionnaire. Kevan Jacobson is a member of advisory boards of AbbVie Canada, Janssen Canada, Amgen, Merck, Viatris and McKesson Canada; a member of the speaker's bureau for AbbVie Canada and Janssen Canada; received investigator-initiated research support from Janssen and Stock options from Engene. Mary Sherlock has served on the advisory board for Sanofi. N.C. has received speaker fees from Sanofi. Colette Deslandres received speaker fees from AbbVie and Janssen. Eileen Crowley has received an educational grant and speaker fees from AbbVie, Pfizer, and consulting fees from Alimentiv Inc and Sanofi. Jennifer deBruyn is a member of the advisory board of Mylan, AbbVie, Amgen, Pfizer; speaker for Pfizer, AbbVie. Thomas Walters has received speaking or consultancy honoraria from AbbVie, Amgen, Janssen, Pfizer, NKS, and Ferring; and grants for research and fellowship support from AbbVie, Merck, and Ferring. Anne M. Griffiths is past holder of the Northbridge Financial Corporation Chair in Inflammatory Bowel Disease, a joint Hospital-University Chair between the University of Toronto, The Hospital for Sick Children, and the SickKids Foundation; has received research support from AbbVie Canada; is co-owner of copyright for the Pediatric Ulcerative Colitis Activity Index and for the TUMMY-UC; has served on the advisory board or as a consultant for AbbVie, Amgen, Bristol Myers Squibb, Janssen, Lilly, Merck, Pfizer, and Takeda; and has received speaker fees from AbbVie, Janssen, and Takeda. Eytan Wine has had previous honoraria from AbbVie, Jannsen, Nestle Health Sciences, and Mead Johnson Nutrition. The remaining authors declare no conflicts of interest. FIR - Critch, Jeff IR - Critch J FIR - Hart, Lara IR - Hart L FIR - Schneider, Rilla IR - Schneider R FIR - Bax, Kevin IR - Bax K FIR - Benchimol, Eric I IR - Benchimol EI EDAT- 2025/11/30 06:31 MHDA- 2026/02/03 00:27 PMCR- 2026/02/03 CRDT- 2025/11/30 00:42 PHST- 2025/10/15 00:00 [revised] PHST- 2025/07/10 00:00 [received] PHST- 2025/11/11 00:00 [accepted] PHST- 2026/02/03 00:27 [medline] PHST- 2025/11/30 06:31 [pubmed] PHST- 2025/11/30 00:42 [entrez] PHST- 2026/02/03 00:00 [pmc-release] AID - JPN370299 [pii] AID - 10.1002/jpn3.70299 [doi] PST - ppublish SO - J Pediatr Gastroenterol Nutr. 2026 Feb;82(2):465-476. doi: 10.1002/jpn3.70299. Epub 2025 Nov 29. PMID- 41318804 OWN - NLM STAT- MEDLINE DCOM- 20260103 LR - 20260603 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 16 IP - 1 DP - 2025 Nov 29 TI - Evaluation of IoT based smart safety systems for women and children using machine learning techniques. PG - 87 LID - 10.1038/s41598-025-29146-4 [doi] LID - 87 AB - Traditional security systems for women and children often fail, limited by manual activation and slow response times. This research presents an IoT-enabled smart safety framework that leverages machine learning (ML) to autonomously detect and respond to physiological distress and potential threats. The proposed system integrates physiological sensors (heart rate, temperature) and activity sensors (GPS, accelerometer) into an intelligent wearable device. A hybrid ML approach, primarily utilizing Support Vector Machine (SVM) and Naive Bayes (NB), is employed for robust activity recognition and stress level classification. Performance was rigorously validated using k-fold cross-validation, with the SVM classifier achieving a 99.7% average accuracy in threat detection. This AI-driven approach reduces detection latency to 3 s, while battery optimization ensures 18-20 h of continuous operation. Upon autonomous threat detection, the system uses GSM connectivity to transmit GPS coordinates to authorities. This research demonstrates a practical, high-accuracy solution for personal security, with a strong emphasis on data privacy and ethical deployment. CI - (c) 2025. The Author(s). FAU - Wagh, Nanda R AU - Wagh NR AD - Department of Information Technology, Dr. Babasaheb Ambedakar Technological University, Lonere, India. nandawagh@dbatu.ac.in. FAU - Sutar, Sanjay R AU - Sutar SR AD - Department of Information Technology, Dr. Babasaheb Ambedakar Technological University, Lonere, India. FAU - Kadam, V J AU - Kadam VJ AD - Department of Information Technology, Dr. Babasaheb Ambedakar Technological University, Lonere, India. FAU - Jadhav, S M AU - Jadhav SM AD - Department of Information Technology, Dr. Babasaheb Ambedakar Technological University, Lonere, India. FAU - Yadav, A S AU - Yadav AS AD - Department of Computer Engineering, SAE Khondwada, SPPU University, Pune, India. FAU - Pawar, V S AU - Pawar VS AD - Department of Computer Engineering, Government Polytechnic, Pune, India. LA - eng PT - Journal Article DEP - 20251129 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Humans MH - Female MH - *Machine Learning MH - Child MH - Wearable Electronic Devices MH - Support Vector Machine MH - Bayes Theorem MH - *Internet of Things MH - Accelerometry PMC - PMC12764881 OTO - NOTNLM OT - Arduino OT - Body sensors OT - GPS OT - Internet of things OT - Raspberry pi OT - Smart band OT - Women security COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics: We all authors provide Ethics Declaration of manuscript publication. Consent to publish: All Authors provide consent to publish research manuscript. TPR as "YES". Information consent: All Researcher provide consent to publish research data, Information. Data privacy and security: All data privacy and Security is preserved. Data integrity: Research maintain Data Integrity. EDAT- 2025/11/30 00:30 MHDA- 2026/01/04 00:31 PMCR- 2025/11/29 CRDT- 2025/11/29 23:25 PHST- 2025/04/12 00:00 [received] PHST- 2025/11/14 00:00 [accepted] PHST- 2026/01/04 00:31 [medline] PHST- 2025/11/30 00:30 [pubmed] PHST- 2025/11/29 23:25 [entrez] PHST- 2025/11/29 00:00 [pmc-release] AID - 10.1038/s41598-025-29146-4 [pii] AID - 29146 [pii] AID - 10.1038/s41598-025-29146-4 [doi] PST - epublish SO - Sci Rep. 2025 Nov 29;16(1):87. doi: 10.1038/s41598-025-29146-4. PMID- 41318522 OWN - NLM STAT- MEDLINE DCOM- 20251130 LR - 20260621 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 25 IP - 1 DP - 2025 Nov 29 TI - The difference in hinge axis position determined by virtual versus conventional planning in orthognathic surgery. PG - 1855 LID - 10.1186/s12903-025-07222-5 [doi] LID - 1855 AB - BACKGROUND: The aim of the study was to compare the hinge axis position (Ax) determined by virtual (VSP) versus conventional orthognathic surgery planning (CSP). METHODS: This retrospective cohort study included 320 (female/male = 204/116, median age 24.0 years) adult patients who received single- or two-jaw surgery originally planned using the CSP method and subsequently reevaluated using the VSP method. Three parameters (alpha = angle between the occlusal plane and reference plane, AxV = perpendicular distance between Ax and the occlusal plane, AxH = perpendicular distance between the upper incisor and AxV) for determining Ax were measured on cephalograms, both in VSP and CSP. Paired t-tests and Bland-Altman plots were used for statistical analysis. RESULTS: Both methods differed significantly with a bias of -1.83[Formula: see text] (95% CI -2.04 to -1.62) for alpha, -0.24 mm (95% CI -0.41 to -0.08) for AxV and 0.46 mm (95% CI 0.27 to 0.65) for AxH, with negative values indicating an overestimation by the CSP method. All differences were within the range considered as clinically acceptable. CONCLUSIONS: There were statistically significant differences in all parameters; however, these differences were small and within the range generally considered to be clinically acceptable. CI - (c) 2025. The Author(s). FAU - Rosenbusch, Jonas AU - Rosenbusch J AD - Department of Orthodontics, University of Munster, Albert-Schweitzer-Campus 1, Gebaude W 30, Munster, 48149, Germany. FAU - Kanemeier, Moritz AU - Kanemeier M AD - Department of Orthodontics, University of Munster, Albert-Schweitzer-Campus 1, Gebaude W 30, Munster, 48149, Germany. FAU - Stamm, Thomas AU - Stamm T AD - Department of Orthodontics, University of Munster, Albert-Schweitzer-Campus 1, Gebaude W 30, Munster, 48149, Germany. FAU - Middelberg, Claudius AU - Middelberg C AD - Department of Orthodontics, University of Munster, Albert-Schweitzer-Campus 1, Gebaude W 30, Munster, 48149, Germany. FAU - Schmid, Jonas Q AU - Schmid JQ AD - Department of Orthodontics, University of Munster, Albert-Schweitzer-Campus 1, Gebaude W 30, Munster, 48149, Germany. jonasquirin.schmid@ukmuenster.de. LA - eng PT - Comparative Study PT - Journal Article DEP - 20251129 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - Female MH - Retrospective Studies MH - *Orthognathic Surgical Procedures/methods MH - Male MH - Adult MH - Young Adult MH - Cephalometry/methods MH - *Patient Care Planning MH - Adolescent PMC - PMC12665204 OTO - NOTNLM OT - Hinge axis OT - Mounting OT - Orthognathic surgery OT - Virtual articulator OT - Virtual surgical planning COIS- Declarations. Ethics approval and consent to participate: The study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Commission of the Medical Faculty of the University of Munster, Germany (2021-120-f-S) on 11 March 2021. A consent to participate is not required for retrospective studies according to local Ethics Commission regulations. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/30 00:30 MHDA- 2025/12/01 00:29 PMCR- 2025/11/29 CRDT- 2025/11/29 23:17 PHST- 2025/04/23 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2025/12/01 00:29 [medline] PHST- 2025/11/30 00:30 [pubmed] PHST- 2025/11/29 23:17 [entrez] PHST- 2025/11/29 00:00 [pmc-release] AID - 10.1186/s12903-025-07222-5 [pii] AID - 7222 [pii] AID - 10.1186/s12903-025-07222-5 [doi] PST - epublish SO - BMC Oral Health. 2025 Nov 29;25(1):1855. doi: 10.1186/s12903-025-07222-5. PMID- 41318433 OWN - NLM STAT- MEDLINE DCOM- 20260106 LR - 20260127 IS - 1471-2393 (Electronic) IS - 1471-2393 (Linking) VI - 26 IP - 1 DP - 2025 Nov 29 TI - Uterine artery S/D ratio and serum CA125 as predictors of early pregnancy loss in women with ovarian endometriomas: a retrospective case-control study. PG - 21 LID - 10.1186/s12884-025-08513-z [doi] LID - 21 AB - BACKGROUND: Endometriosis affects approximately 10% of women of reproductive age and is associated with increased risks of infertility and miscarriage. Although the spontaneous miscarriage rate in women with endometriosis is higher than in the general population, specific risk factors and predictive markers for early pregnancy loss in this population remain poorly understood, particularly for women with smaller endometriomas who achieve natural conception. This study aimed to investigate risk factors for early spontaneous miscarriage in women with endometriosis with natural conception and evaluate the predictive value of uterine artery blood flow parameters and serum CA125 levels. METHODS: This retrospective case-control study was conducted at the Fujian Maternity and Child Health Hospital and included 209 women with ovarian endometriomas smaller than 4 cm who achieved natural conception and intrauterine pregnancy between January 2022 and June 2024. Patients were divided into spontaneous miscarriage group (n = 61, 29.19%) and non-miscarriage group (n = 148, 70.81%) based on early pregnancy outcomes. All patients underwent follicular monitoring, endometrial assessment, and uterine artery blood flow evaluation starting from cycle days 9-10. All patients received uniform luteal support with dydrogesterone (20 mg daily from post-ovulation until 10 weeks of gestation). Variables analyzed included demographic characteristics, dysmenorrhea visual analog scale (VAS) scores, CA125 levels, baseline endocrine hormones, ovarian endometrioma characteristics, and uterine artery blood flow parameters including bilateral mean pulsatility index (PI), resistance index (RI), and systolic/diastolic ratio (S/D). RESULTS: No significant differences were observed between groups regarding age (29.08 +/- 4.64 vs. 30.42 +/- 5.09, P = 0.078), body mass index (23.15 +/- 2.37 vs. 23.54 +/- 2.80, P = 0.333), parity, or baseline endocrine parameters. The miscarriage group showed significantly higher CA125 levels (33.53 +/- 11.87 vs. 25.57 +/- 10.54, P < 0.001), bilateral mean S/D ratio (7.90 +/- 3.26 vs. 5.56 +/- 2.06, P < 0.001), bilateral mean PI (2.51 +/- 0.43 vs. 2.22 +/- 0.45, P < 0.001), and VAS scores (median 3.00 vs. 1.00, P < 0.001). Multivariate logistic regression analysis revealed that bilateral mean S/D ratio (OR = 1.38, 95% CI: 1.15-1.66, P < 0.001) and CA125 levels (OR = 1.08, 95% CI: 1.04-1.12, P < 0.001) were independently associated with increased risk of early spontaneous miscarriage. ROC analysis demonstrated good predictive value for S/D ratio (AUC = 0.75, cutoff = 6.49) and CA125 (AUC = 0.76, cutoff = 23.55), with improved diagnostic accuracy when combined (AUC = 0.85, sensitivity = 0.87, specificity = 0.72). CONCLUSIONS: Elevated serum CA125 levels and increased uterine artery S/D ratio are independently associated with increased risk of early spontaneous miscarriage in women with endometriosis with ovarian endometriomas smaller than 4 cm who conceive naturally. The combined assessment of CA125 levels and uterine artery S/D ratio during early pregnancy provides useful risk stratification for identifying high-risk patients, potentially enabling targeted interventions to improve pregnancy outcomes in these women. CI - (c) 2025. The Author(s). FAU - Lin, Yin AU - Lin Y AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, 18 Daoshan Road, Gulou District, Fuzhou City, Fujian Province, China. FAU - Jiang, Junying AU - Jiang J AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, 18 Daoshan Road, Gulou District, Fuzhou City, Fujian Province, China. FAU - Lin, Hao AU - Lin H AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, 18 Daoshan Road, Gulou District, Fuzhou City, Fujian Province, China. FAU - Yan, Hong AU - Yan H AD - Department of Medical Ultrasonics, Fujian Maternity and Child Health Hospital, Fuzhou, China. FAU - Deng, Ting AU - Deng T AD - Department of Gynecology, Fujian Maternity and Child Health Hospital, 18 Daoshan Road, Gulou District, Fuzhou City, Fujian Province, China. doctordeng2022@163.com. LA - eng PT - Journal Article DEP - 20251129 PL - England TA - BMC Pregnancy Childbirth JT - BMC pregnancy and childbirth JID - 100967799 RN - 0 (CA-125 Antigen) RN - 0 (MUC16 protein, human) RN - 0 (Biomarkers) RN - 0 (Membrane Proteins) SB - IM MH - Humans MH - Female MH - *CA-125 Antigen/blood MH - Retrospective Studies MH - Adult MH - Pregnancy MH - *Endometriosis/complications/blood MH - Case-Control Studies MH - *Uterine Artery/diagnostic imaging/physiopathology MH - *Abortion, Spontaneous/blood/etiology MH - *Ovarian Diseases/complications/blood MH - Risk Factors MH - Predictive Value of Tests MH - Biomarkers/blood MH - Membrane Proteins PMC - PMC12771923 OTO - NOTNLM OT - CA125 OT - Endometriosis OT - Predictive model OT - Pregnancy loss OT - Uterine artery doppler COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Ethics Committee of Fujian Maternity and Child Health Hospital (2025KY023) and conducted in accordance with the principles of the Declaration of Helsinki. Given the retrospective nature of this study using de-identified data, the requirement for informed consent was waived by the Ethics Committee of Fujian Maternity and Child Health Hospital. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/30 00:30 MHDA- 2026/01/06 19:17 PMCR- 2025/11/29 CRDT- 2025/11/29 23:14 PHST- 2025/09/19 00:00 [received] PHST- 2025/11/18 00:00 [accepted] PHST- 2026/01/06 19:17 [medline] PHST- 2025/11/30 00:30 [pubmed] PHST- 2025/11/29 23:14 [entrez] PHST- 2025/11/29 00:00 [pmc-release] AID - 10.1186/s12884-025-08513-z [pii] AID - 8513 [pii] AID - 10.1186/s12884-025-08513-z [doi] PST - epublish SO - BMC Pregnancy Childbirth. 2025 Nov 29;26(1):21. doi: 10.1186/s12884-025-08513-z. PMID- 41317196 OWN - NLM STAT- MEDLINE DCOM- 20251129 LR - 20260919 IS - 1433-7339 (Electronic) IS - 0941-4355 (Print) IS - 0941-4355 (Linking) VI - 33 IP - 12 DP - 2025 Nov 29 TI - Haematopoietic stem cell transplantation for children and young people: is there a role for prehabilitation? A scoping review. PG - 1149 LID - 10.1007/s00520-025-09988-4 [doi] LID - 1149 AB - PURPOSE: Prehabilitation interventions show positive outcomes for adults undergoing haematopoietic stem cell transplantation (HSCT). Their impact on paediatric populations is less clear. This scoping review describes current prehabilitation literature, intervention feasibility, and effectiveness in improving health outcomes for children following HSCT. METHODS: Following the Joanna Briggs Institute methodology, a comprehensive search of databases (AHMED, CINAHL, Cochrane library, EMCARE, MEDLINE, PsycINFO, PubMed) and grey literature was conducted. Key search terms included "HSCT", "prehabilitation" (physical functioning, nutritional status, health behaviours), "children/young people" and "health outcomes". Data related to review aims was extracted. RESULTS: From 134 studies, nine met inclusion criteria (three (33%) on physical functioning, six (67%) examined nutritional status, 0 health behaviours). Eight (89%) were retrospective, with one prospective providing baseline data from a RCT. Pre-HSCT muscle strength, endurance, balance, and quality of life are lower than age-matched peers. Higher pre-HSCT muscle strength (hip flexion p = 0.002) and physical function (10 m walk p = 0.004, time-to-rise-from-floor p < 0.001) correlate with improved post-HSCT recovery. Underweight (p-values 0.035-0.044) and overweight status (p-values 0.0021-0.0413) are associated with adverse clinical outcomes. Feasibility of assessment is demonstrated with no adverse events recorded. CONCLUSION: Initial results are promising, with a clear need for pre-HSCT assessment in clinical settings; however, no conclusions on the effectiveness of prehabilitation can be drawn. Findings emphasise the need for further research, supporting grant applications for intervention protocols. CI - (c) 2025. The Author(s). FAU - Rowley, Debbi AU - Rowley D AUID- ORCID: 0000-0002-1241-1101 AD - Haematology and Oncology, Sheffield Children's Foundation Trust, Clarkson Street, Broomhall, Sheffield, S10 2TH, UK. Deborah.rowley2@nhs.net. AD - Children's Health and Exercise Centre, Faculty of Public Health and Sports Sciences, Medical School, University of Exeter, Exeter, UK. Deborah.rowley2@nhs.net. FAU - Iniesta, Raquel Revuelta AU - Iniesta RR AD - Children's Health and Exercise Centre, Faculty of Public Health and Sports Sciences, Medical School, University of Exeter, Exeter, UK. FAU - Patrick, Katharine AU - Patrick K AD - Haematology and Oncology, Sheffield Children's Foundation Trust, Clarkson Street, Broomhall, Sheffield, S10 2TH, UK. FAU - Massey, Sarah AU - Massey S AD - Illingworth Library, Sheffield Children's Foundation Trust, Sheffield, UK. FAU - Wright, Peter AU - Wright P AUID- ORCID: 0009-0004-0492-8292 AD - Oxford Brookes University, Oxford, UK. LA - eng GR - CCLGA 2024 02 Rowley/Children's Cancer and Leukaemia Group/ PT - Journal Article PT - Scoping Review DEP - 20251129 PL - Germany TA - Support Care Cancer JT - Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer JID - 9302957 SB - IM MH - Humans MH - *Hematopoietic Stem Cell Transplantation/methods MH - Child MH - Adolescent MH - Quality of Life MH - Nutritional Status MH - Muscle Strength MH - *Preoperative Exercise PMC - PMC12664845 OTO - NOTNLM OT - Childhood cancer OT - Haematopoietic stem cell transplantation OT - Nutrition OT - Pediatrics OT - Physical functioning COIS- Declarations. Competing interests: Funding Debbi Rowley received research funding from the Childhood Cancer and Leukaemia Group, UK as stated in the funding section of the application. EDAT- 2025/11/29 12:30 MHDA- 2025/11/29 12:31 PMCR- 2025/11/29 CRDT- 2025/11/29 11:03 PHST- 2025/05/22 00:00 [received] PHST- 2025/09/25 00:00 [accepted] PHST- 2025/11/29 12:31 [medline] PHST- 2025/11/29 12:30 [pubmed] PHST- 2025/11/29 11:03 [entrez] PHST- 2025/11/29 00:00 [pmc-release] AID - 10.1007/s00520-025-09988-4 [pii] AID - 9988 [pii] AID - 10.1007/s00520-025-09988-4 [doi] PST - epublish SO - Support Care Cancer. 2025 Nov 29;33(12):1149. doi: 10.1007/s00520-025-09988-4. PMID- 41317077 OWN - NLM STAT- MEDLINE DCOM- 20251129 LR - 20260918 IS - 1753-4666 (Electronic) IS - 1753-4658 (Print) IS - 1753-4658 (Linking) VI - 19 DP - 2025 Jan-Dec TI - Association of age, hospitalizations, and physical activity with urinary incontinence in cystic fibrosis: a multicenter cross-sectional study. PG - 17534666251397474 LID - 10.1177/17534666251397474 [doi] LID - 17534666251397474 AB - BACKGROUND: Females with cystic fibrosis (fwCF) are at increased risk of urinary incontinence (UI), likely due to chronic coughing and elevated intra-abdominal pressure. Prevalence rates reported in the literature vary widely, and no large multicenter study has been carried out to date. OBJECTIVE: To estimate the prevalence and severity of UI in fwCF and to investigate clinical variables associated with UI. DESIGN: A multicenter, cross-sectional study conducted across 21 Italian CF centers. METHODS: UI prevalence and severity were assessed using two validated questionnaires. A multivariable fractional polynomial approach was used to select variables for inclusion in the final logistic regression model to identify relevant associations with UI. RESULTS: UI was present in 218/542 females (40.2%, 95% Confidence Interval (CI): 36.1-44.5). Among children and adolescents, the prevalence was 12/160 (7.5%, 95% CI: 4.1-13), whereas among adults it was 206/382 (53.9%, 95% CI: 48.8-59). FwCF with UI showed a BMI of 0.2 Z score higher (95% CI: 0.1-0.4) than fwCF without UI; however, the overall prevalence of UI in fwCF overweight was 41% (95% CI: 30.2-52.7) compared to 40.1% (95%CI: 35.6-44.7) in fwCF with normal weight. Age (interquartile range-odds ratio (IQR-OR) 4.19, 95% CI: 2.80-6.28), days of hospitalization (IQR-OR 1.72, 95% CI: 1.42-2.08), and physical activity (OR 0.66, 95% CI: 0.53-0.82) were the only factors statistically associated with UI. CONCLUSION: UI affects mostly adult fwCF and is associated with older age and longer hospitalization. Physical activity of ⩾150 min per week was also associated with a reduced probability of UI. FAU - Carta, Federica AU - Carta F AD - Healthcare Professions Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. FAU - Malvezzi, Anna AU - Malvezzi A AD - UOC Fibrosi Cistica, Azienda Ospedaliera Universitaria Integrata (AOUI), Verona, Italy. FAU - Innocenti, Diletta AU - Innocenti D AD - Rehabilitation Unit, Meyer Children's Hospital IRCCS, Florence, Italy. FAU - d'Ippolito, Marcella AU - d'Ippolito M AD - Centro di Riferimento Regionale per la Fibrosi Cistica dell'adulto della Campania, DAI Medicina Interna e della complessita clinica, Azienda Ospedaliero Universitaria Federico II di Napoli, Naples, Italy. FAU - Piermarini, Irene AU - Piermarini I AD - UOC Pneumologia e Fibrosi Cistica, IRCCS Ospedale Pediatrico Bambin Gesu, Rome, Italy. FAU - Retucci, Mariangela AU - Retucci M AD - Healthcare Professions Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy. FAU - Colombo, Carla AU - Colombo C AD - Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy. FAU - Gambazza, Simone AU - Gambazza S AUID- ORCID: 0000-0002-6225-2989 AD - Department of Clinical Sciences and Community Health, Dipartimento di Eccellenza 2023-2027, Laboratory of Medical Statistics, Biometry and Epidemiology "G. A. Maccacaro", Universita degli Studi di Milano. Via Celoria 22, Milan 20133, Italy. AD - Healthcare Professions Department, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, via Francesco Sforza 35, Milan 20122, Italy. CN - CrISP Study Group LA - eng PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20251129 PL - England TA - Ther Adv Respir Dis JT - Therapeutic advances in respiratory disease JID - 101316317 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - *Cystic Fibrosis/epidemiology/physiopathology/complications/diagnosis MH - *Urinary Incontinence/epidemiology/physiopathology/etiology/diagnosis MH - *Hospitalization/statistics & numerical data MH - Adolescent MH - Prevalence MH - Adult MH - Child MH - Italy/epidemiology MH - Age Factors MH - Young Adult MH - Severity of Illness Index MH - Risk Factors MH - Male MH - Surveys and Questionnaires MH - Middle Aged MH - Body Mass Index MH - Logistic Models PMC - PMC12665006 OAB - How Age, Hospitalizations, and Physical Activity Are Linked to Urinary Incontinence in People with Cystic FibrosisThis study looked at how common urinary incontinence (UI) is among females with cystic fibrosis (fwCF) in Italy, and what factors might be linked to it. UI is thought to be more common in fwCF because of frequent coughing and pressure in the belly. Researchers collected data from 21 cystic fibrosis centers using two questionnaires. A total of 542 females took part. They found that 40% of fwCF had UI. It was much more common in adults (54%) than in children and teens (7.5%). Women with UI had slightly higher body mass index (BMI), but being overweight didn't seem to increase the risk compared to those with normal weight. The study found that three factors were strongly linked to UI: being older, spending more days in the hospital, and doing less physical activity. Interestingly, women who exercised more than 150 minutes per week had a lower risk of UI. This suggests that staying physically active might help prevent or reduce urinary problems in females with cystic fibrosis. In summary, urinary incontinence is common among adult females with cystic fibrosis and is linked to age and time spent in the hospital. Regular physical activity appears to offer some protection. OABL- eng OTO - NOTNLM OT - cystic fibrosis OT - epidemiology OT - urinary incontinence COIS- The authors declare that the study was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. SG received fees as a consultant for BGP Products Operations GmbH (Part of Mylan Group, CH). EDAT- 2025/11/29 12:30 MHDA- 2025/11/29 12:31 PMCR- 2025/11/29 CRDT- 2025/11/29 08:34 PHST- 2025/11/29 12:31 [medline] PHST- 2025/11/29 12:30 [pubmed] PHST- 2025/11/29 08:34 [entrez] PHST- 2025/11/29 00:00 [pmc-release] AID - 10.1177_17534666251397474 [pii] AID - 10.1177/17534666251397474 [doi] PST - ppublish SO - Ther Adv Respir Dis. 2025 Jan-Dec;19:17534666251397474. doi: 10.1177/17534666251397474. Epub 2025 Nov 29. PMID- 41316894 OWN - NLM STAT- MEDLINE DCOM- 20251129 LR - 20260826 IS - 1740-8709 (Electronic) IS - 1740-8695 (Print) IS - 1740-8695 (Linking) VI - 22 IP - 1 DP - 2026 Jan TI - Women's Empowerment Dimensions and Child Stunting in Ethiopia: A Multilevel Analysis of Demographic and Health Surveys 2011-2016. PG - e70136 LID - 10.1111/mcn.70136 [doi] LID - e70136 AB - Child stunting affects 38.3% of children under five in Ethiopia as of 2016. Women's empowerment, defined through both fundamental capabilities and household decision-making authority, has emerged as a critical determinant of child nutritional outcomes. Drawing on Sen's capability approach and Kabeer's empowerment framework, we examined the associations between two distinct dimensions of women's empowerment and child stunting across Ethiopia's diverse regions. We analyzed 18,466 mother-child pairs from the 2011 and 2016 Ethiopia Demographic and Health Surveys. Validated empowerment indices were constructed using factor analysis. We employed hierarchical multilevel models as our primary specification to examine the associations between women's empowerment and child stunting across Ethiopia's 11 administrative regions. Between 2011 and 2016, stunting declined from 42.3% to 36.4%. Women's decision-making authority increased (mean score: 0.70-0.78), while capabilities remained stable (0.17- 0.16). Higher capabilities were significantly associated with lower odds of stunting (beta = -0.141, aOR = 0.87, 95% CI: 0.83, 0.91), whereas decision-making showed no association (beta = 0.013, aOR = 1.01, 95% CI: 0.98, 1.05). A significant interaction between capabilities and decision-making was observed (beta = 0.050, aOR = 1.05, 95% CI: 1.01, 1.09). Regional heterogeneity was substantial: Amhara maintained high stunting rates despite empowerment gains, while Somali saw improvements with low capabilities but increased decision-making. The study findings suggest that interventions should prioritize capability development through region-specific strategies reflecting diverse pastoral, agrarian, and urban contexts; promote multi-sectoral programs linking education and nutrition services; and develop monitoring frameworks to track both dimensions of empowerment at the regional level. CI - (c) 2025 The Author(s). Maternal & Child Nutrition published by John Wiley & Sons Ltd. FAU - Mengesha, Seyoum Teffera AU - Mengesha ST AUID- ORCID: 0000-0002-6148-0605 AD - Department of Economics, College of Business and Economics, Bahir Dar University, Bahir Dar, Ethiopia. AD - Institute of Economics, Corvinus University of Budapest, Budapest, Hungary. FAU - Berde, Eva AU - Berde E AUID- ORCID: 0000-0001-5614-0801 AD - Szechenyi Istvan University, Gyor, Hungary. FAU - Zerihun Yohannes, Amare AU - Zerihun Yohannes A AUID- ORCID: 0000-0002-4503-6790 AD - Department of Disaster Risk Management & Sustainable Development, Institute of Disaster Risk Management and Food Security Studies, Bahir Dar University, Bahir Dar, Ethiopia. FAU - Remsei, Sandor AU - Remsei S AUID- ORCID: 0000-0001-8862-4544 AD - Szechenyi Istvan University, Gyor, Hungary. LA - eng PT - Journal Article PL - England TA - Matern Child Nutr JT - Maternal & child nutrition JID - 101201025 SB - IM MH - Humans MH - Ethiopia/epidemiology MH - Female MH - *Empowerment MH - *Growth Disorders/epidemiology MH - Adult MH - Multilevel Analysis MH - Child, Preschool MH - Health Surveys MH - Infant MH - *Mothers/statistics & numerical data/psychology MH - Young Adult MH - Male MH - Adolescent MH - Decision Making PMC - PMC13344139 OTO - NOTNLM OT - Ethiopia OT - child stunting OT - demographic health surveys OT - regional heterogeneity OT - women's empowerment COIS- The authors declare no conflicts of interest related to this study. EDAT- 2025/11/29 06:28 MHDA- 2025/11/29 06:29 PMCR- 2025/11/29 CRDT- 2025/11/29 05:12 PHST- 2025/09/26 00:00 [revised] PHST- 2025/03/04 00:00 [received] PHST- 2025/10/16 00:00 [accepted] PHST- 2025/11/29 06:29 [medline] PHST- 2025/11/29 06:28 [pubmed] PHST- 2025/11/29 05:12 [entrez] PHST- 2025/11/29 00:00 [pmc-release] AID - MCN70136 [pii] AID - 10.1111/mcn.70136 [doi] PST - ppublish SO - Matern Child Nutr. 2026 Jan;22(1):e70136. doi: 10.1111/mcn.70136. PMID- 41316836 OWN - NLM STAT- MEDLINE DCOM- 20251129 LR - 20260722 IS - 1758-0854 (Electronic) IS - 1758-0846 (Print) IS - 1758-0854 (Linking) VI - 17 IP - 6 DP - 2025 Dec TI - Within-person association between affect and physical activity related to depressive symptomatology: A systematic review and methodological reflections. PG - e70086 LID - 10.1111/aphw.70086 [doi] LID - e70086 AB - Physical activity can improve mental health by improving mood and by lowering depressive symptoms. This systematic review uses a structured narrative synthesis to summarise within-person associations between physical activity and affect in naturalistic settings, and how these associations may differ by level of depressive symptomatology. We also reviewed the methodological choices that could influence these outcomes and provide a methodological roadmap as a recommendation for future studies. A systematic review was conducted up to December 2024 of studies that addressed within-person associations between daily physical activity and affect using ambulatory assessment techniques in individuals aged 4-65 years and assessed depressive symptoms. Our selection yielded 32 eligible studies. A consistent finding was the positive within-person association between physical activity and concurrent or subsequent positive affect, while results were mixed for negative affect. Results were further inconclusive regarding the role of depression in this relationship. Common challenges affecting replicability include an often-inadequate assessment of measurement reliability and validity, and insufficient controls for relevant (contextual) factors in these analyses, such as the length of the time-lag and mode of physical activity. Future studies should employ emerging best practices regarding study design, analysis and reporting of ambulatory assessment data. Such rigorous research practice will strengthen our understanding of these relationships and further inform more effective, personalised physical activity interventions to improve mood and depressive symptoms. CI - (c) 2025 The Author(s). Applied Psychology: Health and Well-Being published by John Wiley & Sons Ltd on behalf of International Association of Applied Psychology. FAU - Vuuregge, Anna H AU - Vuuregge AH AD - Brain Plasticity group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands. AD - Centre for Urban Mental Health, University of Amsterdam, Amsterdam, the Netherlands. FAU - Zhang, Yong AU - Zhang Y AUID- ORCID: 0000-0002-6313-2575 AD - Department of Psychometrics and Statistics, Faculty of Behavioral and Social Sciences, University of Groningen, Groningen, the Netherlands. FAU - Meulmeester, Werner M AU - Meulmeester WM AD - Brain Plasticity group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands. FAU - Bockting, Claudi L AU - Bockting CL AD - Centre for Urban Mental Health, University of Amsterdam, Amsterdam, the Netherlands. AD - Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam, the Netherlands. FAU - Lucassen, Paul J AU - Lucassen PJ AD - Brain Plasticity group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands. AD - Centre for Urban Mental Health, University of Amsterdam, Amsterdam, the Netherlands. FAU - Heininga, Vera E AU - Heininga VE AUID- ORCID: 0000-0003-0889-8524 AD - Faculty of Behavioral and Social Sciences, University of Groningen, Groningen, the Netherlands. FAU - Schrantee, Anouk AU - Schrantee A AD - Centre for Urban Mental Health, University of Amsterdam, Amsterdam, the Netherlands. AD - Amsterdam UMC, University of Amsterdam, Department of Radiology and Nuclear Medicine, Amsterdam, the Netherlands. FAU - Mul, Joram D AU - Mul JD AUID- ORCID: 0000-0003-0453-2568 AD - Brain Plasticity group, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, the Netherlands. AD - Centre for Urban Mental Health, University of Amsterdam, Amsterdam, the Netherlands. LA - eng GR - Centre for Urban Mental Health/ GR - NWO-ICNS/ GR - ZonMw MODEM/ GR - Alzheimer Nederland/ PT - Journal Article PT - Systematic Review PL - England TA - Appl Psychol Health Well Being JT - Applied psychology. Health and well-being JID - 101502957 SB - IM MH - Humans MH - *Exercise/psychology/physiology MH - *Depression/physiopathology/psychology MH - *Affect/physiology MH - Adult MH - Middle Aged MH - Child MH - Adolescent MH - Aged MH - Young Adult MH - Child, Preschool PMC - PMC12663757 OTO - NOTNLM OT - ambulatory assessment OT - daily life OT - exercise OT - methodology OT - mood COIS- The authors declare no conflicts of interest. EDAT- 2025/11/29 06:27 MHDA- 2025/11/29 06:28 PMCR- 2025/11/29 CRDT- 2025/11/29 03:42 PHST- 2025/04/02 00:00 [received] PHST- 2025/09/22 00:00 [accepted] PHST- 2025/11/29 06:28 [medline] PHST- 2025/11/29 06:27 [pubmed] PHST- 2025/11/29 03:42 [entrez] PHST- 2025/11/29 00:00 [pmc-release] AID - APHW70086 [pii] AID - 10.1111/aphw.70086 [doi] PST - ppublish SO - Appl Psychol Health Well Being. 2025 Dec;17(6):e70086. doi: 10.1111/aphw.70086. PMID- 41316463 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260104 LR - 20260106 IS - 2047-0525 (Print) IS - 2047-0525 (Electronic) IS - 2047-0525 (Linking) VI - 15 IP - 1 DP - 2025 Nov 28 TI - MiR-18a-5p serves as a risk factor in perioperative respiratory adverse events in children under general anesthesia. PG - 3 LID - 10.1186/s13741-025-00629-2 [doi] LID - 3 AB - PURPOSE: Perioperative respiratory adverse events (PRAEs) are frequently encountered complications in pediatric anesthesia. The purpose of this experiment is to explore the significant role of miR-18a-5p in PRAEs, thereby providing a novel biomarker for PRAE clinical management. METHODS: Clinical data from 174 children undergoing general anesthesia were analyzed. MiR-18a-5p expression in serum and cells was analyzed via real-time quantitative PCR (qRT-PCR). Its diagnostic value for PRAEs was evaluated through receiver operating characteristic (ROC) curves, while logistic regression was selected to assess independent risk factors for PRAEs. In vitro experiments were conducted to determine miR-18a-5p effects on AEC-II cells proliferation, apoptosis, and lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6) secretion. RESULTS: PRAEs subjects exhibited significantly elevated miR-18a-5p levels with diagnostic relevance. Expression correlated positively with TNF-alpha/IL-6 concentrations and was associated with age, obesity, American Society of Anesthesiologists (ASA) grade, and anesthesia duration. These parameters jointly constituted the PRAEs predictors. Furthermore, miR-18a-5p silencing enhanced AEC-II cells' viability while suppressing apoptosis and LPS-triggered TNF-alpha and IL-6 release. CONCLUSION: The miR-18a-5p served as a predictive factor and held diagnostic significance for PRAEs following general anesthesia in children. Additionally, miR-18a-5p may offer potential therapeutic implications for PRAEs. CI - (c) 2025. The Author(s). FAU - Zhang, Lin AU - Zhang L AD - The First Clinical Medical College, Heilongjiang University of Chinese Medicine, Harbin, 150400, China. FAU - Yu, Xinyuan AU - Yu X AD - Department of Neurosurgery, Renmin Hospital of Wuhan University, Wuhan, 430060, China. FAU - Liu, Jun AU - Liu J AD - Department of Anesthesiology, Affiliated Hospital of Gansu Medical College (People's Hospital of pingliang), Gansu, 744000, China. FAU - Han, Xiaotong AU - Han X AD - Department of Anesthesiology, Affiliated Hospital of Gansu Medical College (People's Hospital of pingliang), Gansu, 744000, China. FAU - Ma, Xiaoning AU - Ma X AD - Operating Room, Affiliated Hospital of Gansu Medical College (People's Hospital of pingliang), Gansu, 744000, China. FAU - Li, Min AU - Li M AD - Department of Nursing, Affiliated Hospital of Gansu Medical College (People's Hospital of pingliang), No. 296, Kongtong East Road, Kongtong District, Pingliang City, Gansu Province, 744000, China. limin744000@163.com. FAU - Liu, Cuiling AU - Liu C AD - Department of Anesthesiology, The People's Hospital of SND, No.95 Huashan Road, Huqiu District, Suzhou City, Jiangsu Province, 215010, China. cuilingliudr@163.com. LA - eng PT - Journal Article DEP - 20251128 PL - England TA - Perioper Med (Lond) JT - Perioperative medicine (London, England) JID - 101609072 PMC - PMC12763970 OTO - NOTNLM OT - Diagnosis OT - MiR-18a-5p OT - Perioperative respiratory adverse events OT - Predictive factor COIS- Declarations. Ethics approval and consent to participate: The study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Affiliated Hospital of Gansu Medical College before the study began. (Ethics Approval Number: 2022E06) The written informed consent has been obtained from the participants involved. Consent for publication: All authors consent to the publication of the article. Competing interests: The authors declare no competing interests. EDAT- 2025/11/29 06:29 MHDA- 2025/11/29 06:30 PMCR- 2025/11/28 CRDT- 2025/11/29 00:59 PHST- 2025/07/21 00:00 [received] PHST- 2025/11/10 00:00 [accepted] PHST- 2025/11/29 06:30 [medline] PHST- 2025/11/29 06:29 [pubmed] PHST- 2025/11/29 00:59 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - 10.1186/s13741-025-00629-2 [pii] AID - 629 [pii] AID - 10.1186/s13741-025-00629-2 [doi] PST - epublish SO - Perioper Med (Lond). 2025 Nov 28;15(1):3. doi: 10.1186/s13741-025-00629-2. PMID- 41316430 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20260106 LR - 20260108 IS - 2055-0928 (Electronic) IS - 2055-0928 (Linking) VI - 12 IP - 1 DP - 2025 Nov 28 TI - Causal effects of Antenatal Care (ANC) on child malnutrition: a machine learning approach in Ethiopia and Rwanda. PG - 1 LID - 10.1186/s40795-025-01208-w [doi] LID - 1 AB - Malnutrition among children under five remains a critical public health challenge in Ethiopia and Rwanda, with nearly half of the children in this study population affected by at least one form of undernutrition. This study provides a robust causal analysis of the heterogeneous effects of Antenatal Care (ANC) on child malnutrition, as measured by the Composite Index of Anthropometric Failure (CIAF). Leveraging data from 33,737 mother-child pairs from the Demographic and Health Surveys (DHS) in Ethiopia (N = 22,668) and Rwanda (N = 11,069) across three waves (2005-2015), we employ a machine learning-based Causal Forest model. This approach was chosen specifically to overcome the limitations of traditional regression methods, allowing for the estimation of how the impact of different levels of ANC attendance varies across diverse sociodemographic and health-related subgroups. The results reveal a clear and powerful dose-response relationship. While a single ANC visit has a negligible effect, attending 2-3 visits is associated with a modest 3.5% point reduction in the risk of malnutrition. The strongest impact is seen with the completion of 4 or more visits, which is associated with an average reduction of 5.7% points (ATE: -0.057). Crucially, this average effect masks profound and policy-relevant heterogeneity. The benefits of ANC are massively amplified for the most vulnerable populations; for children in the poorer wealth quintile, 4 + ANC visits are associated with a massive 17.1% point reduction in malnutrition risk-an effect nearly three times the population average. The intervention is also particularly impactful for older mothers (aged 35-49), where it is associated with an 11.9% point risk reduction. Furthermore, the benefits of ANC are amplified by a healthier environment; for children in households with an improved water source, the associated risk reduction is a substantial 7.8% points, demonstrating a powerful synergistic effect between clinical care and public health infrastructure. The application of the Causal Forest model represents a significant advancement, moving beyond a single average effect to uncover this critical heterogeneity and identify for whom, and under what conditions, ANC is most effective. These findings provide robust causal evidence for a necessary shift away from a one-size-fits-all public health strategy. The results strongly advocate for stratified and multi-sectoral interventions. Policy and resources should be intensely focused on ensuring the most vulnerable populations-particularly the poorest households and older mothers-complete the full ANC schedule, as this is where the public health return on investment is highest. Additionally, the synergistic effect with WASH highlights the need to integrate clinical maternal health programs with investments in community-level water and sanitation infrastructure. By tailoring ANC programs and combining them with broader public health improvements, governments can develop more holistic and effective strategies to accelerate progress against child malnutrition in Ethiopia, Rwanda, and comparable high-burden contexts. CI - (c) 2025. The Author(s). FAU - Tessema, Alehegn Moges AU - Tessema AM AD - African Center of Excellence in Data Science, University of Rwanda, Kigali, Rwanda. moges.alehegn@gmail.com. FAU - Zewotir, Temesgen AU - Zewotir T AD - School of Mathematics, Statistics and Computer Sciences, University of KwaZulu- Natal, Durban, South Africa. FAU - Kabanda, Richard AU - Kabanda R AD - African Center of Excellence in Data Science, University of Rwanda, Kigali, Rwanda. LA - eng PT - Journal Article DEP - 20251128 PL - England TA - BMC Nutr JT - BMC nutrition JID - 101672434 PMC - PMC12771955 OTO - NOTNLM OT - 5-fold Cross-Validation OT - Antenatal care (ANC) OT - Causal forest model OT - Child malnutrition OT - Composite index of anthropometric failure (CIAF) OT - Heterogeneous treatment effects OT - Machine learning COIS- Declarations. Ethics approval and consent to participate: Not Applicable. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/29 06:28 MHDA- 2025/11/29 06:29 PMCR- 2025/11/28 CRDT- 2025/11/29 00:58 PHST- 2025/02/28 00:00 [received] PHST- 2025/10/31 00:00 [accepted] PHST- 2025/11/29 06:29 [medline] PHST- 2025/11/29 06:28 [pubmed] PHST- 2025/11/29 00:58 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - 10.1186/s40795-025-01208-w [pii] AID - 1208 [pii] AID - 10.1186/s40795-025-01208-w [doi] PST - epublish SO - BMC Nutr. 2025 Nov 28;12(1):1. doi: 10.1186/s40795-025-01208-w. PMID- 41316363 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251129 LR - 20251201 IS - 2050-2974 (Print) IS - 2050-2974 (Electronic) IS - 2050-2974 (Linking) VI - 13 IP - 1 DP - 2025 Nov 28 TI - Examining the association among eating disorders and borderline personality disorder: evidence from youth in Saudi Arabia. PG - 276 LID - 10.1186/s40337-025-01455-z [doi] LID - 276 AB - BACKGROUND: Borderline Personality Disorder (BPD) is a complex psychiatric condition manifest by persistent instability in emotions, relationships, self-perception, and behavior. Eating disorders (EDs) are multifaceted neuropsychiatric conditions involving dysfunctional eating behaviors and psychological impairments, leading to adverse health outcomes and reduced quality of life. They are also associated with some of the highest mortality rates in psychiatry. EDs are typically classified to three main types: anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). Personality disorders are reflected as potential risk factors in the development of EDs. This study aimed to investigate the association between EDs and BPD among youth in Saudi Arabia. METHODS: A total of 433 participants aged 18-34 were included in this study. The research employed a quantitative, cross-sectional design, conducted between September and November 2024. Data were collected via an online questionnaire comprising three sections: demographic and health-related information, the McLean Screening Instrument (MSI-BPD) for BPD, and the Eating Disorder Questionnaire-Online (EDQ-O) for EDs. The design aimed to validate self-reported BPD symptoms and explore their association with EDs. RESULTS: The majority of the participants were female and educated Saudi persons who had no chronic illnesses; a notable 22.2% reported a formal diagnosis of BPD. The prevalence of EDs among the participants was found to be 67.9%. The findings revealed that BED was the most prevalent EDs among participants (45.03%), followed by BN at 22.17%, while AN was the least common (0.69%), indicating a higher occurrence of BED in the studied population. MSI-BPD screening results showed that 150 participants (34.64%) tested positive for BPD, with a higher prevalence among females (37.17%) compared to males (18.64%). A notably higher prevalence of EDs, particularly BED (74.67%) and BN (42.67%), was observed among participants with BPD, while AN remained rare in both groups. Pearson correlation analysis revealed statistically significant correlations (p < 0.01) between BPD and each EDs subtype (AN, BN, and BED), and the overall EDs symptom score. CONCLUSION: This study indicates a notable comorbidity between BPD and EDs, particularly BED and BN, reinforcing the strong tendency of these disorders to co-occur. CI - (c) 2025. The Author(s). FAU - Mansoury, Manal M S AU - Mansoury MMS AUID- ORCID: 0000-0003-0784-1825 AD - Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, Saudi Arabia. mmmansouri@kau.edu.sa. FAU - Alsufyani, Shuruq A AU - Alsufyani SA AD - Department of Food and Nutrition, Faculty of Human Sciences and Design, King Abdulaziz University, Jeddah, Saudi Arabia. FAU - Alghamdi, Fatemah S AU - Alghamdi FS AUID- ORCID: 0000-0003-0452-9297 AD - Department of Psychology, Faculty of Art and Humanities, King Abdulaziz University, Jeddah, Saudi Arabia. LA - eng PT - Journal Article DEP - 20251128 PL - England TA - J Eat Disord JT - Journal of eating disorders JID - 101610672 PMC - PMC12664173 OAB - This study examined the association between borderline personality disorder (BPD) and eating disorders (EDs) in youth in Saudi Arabia. BPD is a mental health condition that can lead to emotional dysregulation, unstable relationships, and identity disturbance. Eating disorders, such as AN, BN, and BED, can have a big effect on both mental and physical health. The study surveyed 433 people aged 18 to 34 about their mental health and eating habits. Approximately one-third of them showed signs of BPD, and more than two-thirds had symptoms of an EDs. BED was the most common type, especially in people with BPD. Women were more likely than men to have both BPD and EDs. This suggests that BPD and EDs often happen together, especially BED and BN. These results show how important it is to offer mental health care that addresses both emotional issues. OABL- eng OTO - NOTNLM OT - Borderline personality disorder OT - Eating disorders OT - Saudi arabia OT - Youth COIS- Declarations. Ethical approval and consent to participate: This study received ethical clearance from the Faculty of Arts and Humanities at King Abdulaziz University, Jeddah (Approval No. 4513481). Participants were fully informed about the study's purpose prior to completing the questionnaire and were given the freedom to participate voluntarily or decline. All data were handled with strict confidentiality, and participant identities remained anonymous. Competing interests: The authors declare no competing interests. EDAT- 2025/11/29 06:29 MHDA- 2025/11/29 06:30 PMCR- 2025/11/28 CRDT- 2025/11/29 00:56 PHST- 2025/08/03 00:00 [received] PHST- 2025/10/30 00:00 [accepted] PHST- 2025/11/29 06:30 [medline] PHST- 2025/11/29 06:29 [pubmed] PHST- 2025/11/29 00:56 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - 10.1186/s40337-025-01455-z [pii] AID - 1455 [pii] AID - 10.1186/s40337-025-01455-z [doi] PST - epublish SO - J Eat Disord. 2025 Nov 28;13(1):276. doi: 10.1186/s40337-025-01455-z. PMID- 41316144 OWN - NLM STAT- MEDLINE DCOM- 20260113 LR - 20260115 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2025 Nov 28 TI - Fostering affect-related competencies and positive affective exercise experiences for promoting a physically active lifestyle in inactive young adults: study protocol for the FEEL cluster randomized controlled trial. PG - 137 LID - 10.1186/s12889-025-24374-9 [doi] LID - 137 AB - BACKGROUND: Growing evidence highlights the role of affective responses in shaping exercise behavior. Various factors, such as social setting, intensity, or activity type, influence affective exercise experiences. However, previous interventions have typically targeted only one factor at a time. The idea of the FEEL exercise program is to address these various factors in a holistic manner. Additionally, it focuses on fostering Physical Activity-Related Affect Regulation (PAAR) competence in participants, which is crucial for maintaining regular exercise behavior and well-being. METHODS: The FEEL study is a multicenter, cluster-randomized controlled trial. It evaluates the FEEL exercise program's efficacy compared to an active control group participating in a standardized Functional Training program. A total of 160 young adults (aged 18-35) who are not regularly exercising will be recruited across the two cities, Tubingen (Germany) and Bern (Switzerland). Both exercise programs consist of eight weekly 90-min group-based sessions. Primary outcome will assess PAAR using a validated scale, while secondary outcomes will include affective exercise experiences (AFFEXX), motivational competence, physical activity levels, and affective well-being. Measurements will be collected at baseline (t1), post-intervention (t2), and at an 8-week follow-up (t3). Data will be analyzed using multilevel modeling to examine group-by-time interactions, following a modified intention-to-treat approach. CONCLUSIONS: This study explores the impact of a holistic intervention in a primary and secondary prevention context. It may provide valuable insights for practical considerations of affective processes and related competencies in exercise programs. TRIAL REGISTRATION (RETROSPECTIVELY ON THE 31.10.2024): German Clinical Trials Register; ID: DRKS00035302. CI - (c) 2025. The Author(s). FAU - Buhrer, Martin AU - Buhrer M AD - Institute of Sport Science, University of Bern, Bremgartenstrasse 145, Bern, CH, 3012, Switzerland. martin.buehrer@unibe.ch. FAU - Rosenstiel, Stephanie AU - Rosenstiel S AD - Institute of Sports Science & Methods Center, Eberhard Karls University of Tubingen, Tubingen, Germany. FAU - Besel, Hannah AU - Besel H AD - Institute of Sports Science & Methods Center, Eberhard Karls University of Tubingen, Tubingen, Germany. FAU - Leyhr, Daniel AU - Leyhr D AD - Institute of Sports Science & Methods Center, Eberhard Karls University of Tubingen, Tubingen, Germany. FAU - Sudeck, Gorden AU - Sudeck G AD - Institute of Sports Science & Methods Center, Eberhard Karls University of Tubingen, Tubingen, Germany. AD - Interfaculty Research Institute for Sport and Physical Activity, Eberhard Karls University of Tubingen, Tubingen, Germany. FAU - Schmid, Julia AU - Schmid J AD - Institute of Sport Science, University of Bern, Bremgartenstrasse 145, Bern, CH, 3012, Switzerland. LA - eng PT - Clinical Trial Protocol PT - Journal Article DEP - 20251128 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Humans MH - *Exercise/psychology MH - Young Adult MH - Adult MH - Adolescent MH - Female MH - Male MH - *Affect MH - *Health Promotion/methods MH - Germany MH - Randomized Controlled Trials as Topic MH - *Sedentary Behavior MH - Multicenter Studies as Topic PMC - PMC12797374 OTO - NOTNLM OT - Body-inclusive spaces OT - Exercise Adherence OT - Experiential learning OT - Health literacy OT - Motivation OT - Physical literacy OT - Pleasure OT - Well-being COIS- Declarations. Ethics approval and consent to participate: The study is conducted according to the Declaration of Helsinki of 2010 guidelines. The study received approval from the Ethics Committee of the Faculty of Economics and Social Sciences at the University of Tubingen, Germany (ID: A2.5.4-334.1_hb) and the Ethics Commission of the Faculty of Human Sciences at the University of Bern, Switzerland (ID: 2024-02-06). Written informed consent is obtained from all participants. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/29 06:28 MHDA- 2026/01/13 07:42 PMCR- 2025/11/28 CRDT- 2025/11/29 00:47 PHST- 2025/03/14 00:00 [received] PHST- 2025/08/08 00:00 [accepted] PHST- 2026/01/13 07:42 [medline] PHST- 2025/11/29 06:28 [pubmed] PHST- 2025/11/29 00:47 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - 10.1186/s12889-025-24374-9 [pii] AID - 24374 [pii] AID - 10.1186/s12889-025-24374-9 [doi] PST - epublish SO - BMC Public Health. 2025 Nov 28;26(1):137. doi: 10.1186/s12889-025-24374-9. PMID- 41316137 OWN - NLM STAT- MEDLINE DCOM- 20251129 LR - 20251202 IS - 1471-2482 (Electronic) IS - 1471-2482 (Linking) VI - 25 IP - 1 DP - 2025 Nov 28 TI - Combined laser ablation and pit excision for pilonidal sinus: effectiveness, quality of recovery, and patient-reported outcomes. PG - 576 LID - 10.1186/s12893-025-03319-4 [doi] LID - 576 AB - BACKGROUND: This retrospective study aimed to evaluate the efficacy, safety, and patient-reported long-term results of a minimally invasive method of diode laser ablation combined with pit excision for pilonidal sinus disease, reveal predictive factors affecting treatment success, and quantitatively examine patient satisfaction and quality of life dimensions. METHODS: Fifty-four adults were treated consecutively, and the primary analysis included 39 patients who 6month patientreported outcomes (PROs: QoR15, SAPS, PROMIS Global10) assessed by an independent investigator. The primary endpoints were recurrence and treatment success (no recurrence without re-intervention). Delayed healing was a composite of epithelialization > 30 days or discharge > 14 days. Exploratory subgroup analyses (sex and BMI) reported effect sizes with Benjamini-Hochberg-adjusted qvalues. Receiver operating characteristic (ROC) curve analysis assessed PRO discrimination for recurrence with 95% confidence intervals (CIs). RESULTS: Mean followup was 13.6 +/- 3.6 months; treatment success 84.6% (33/39), recurrence 15.4% (6/39), and delayed healing 20.5% (8/39). Mean PROs were: QoR15 136.8 +/- 19.9, SAPS 30.4 +/- 4.3, PROMIS 46.2 +/- 6.8; early postoperative pain (VAS) 1.9 +/- 1.3. QoR15, SAPS, and PROMIS correlated inversely with recurrence (r = - 0.46 to - 0.36; all p < 0.05) and showed AUCs of 0.79 (95% CI 0.65-0.93), 0.73 (0.58-0.88), and 0.70 (0.54-0.86), respectively. Age was associated with a longer recovery time (p = 0.002). No material differences in PROs by sex or BMI were observed after multiplicity control. CONCLUSIONS: In this single-center consecutive cohort, combined diode laser ablation with a pit excision technique was associated with short perioperative timelines, high patient-reported recovery/satisfaction, and acceptable mid-term recurrence, whereas PRO scores demonstrated fair discrimination for recurrence. Findings should be interpreted cautiously given the retrospective design and modest sample size; prospective, adequately powered studies are needed to validate the prognostic performance and comparative effectiveness. CI - (c) 2025. The Author(s). FAU - Canturk, Alp Omer AU - Canturk AO AUID- ORCID: 0000-0003-3641-7628 AD - Department of General Surgery, Sakarya Training and Research Hospital, Sakarya, Turkey. dr.omercanturk@gmail.com. FAU - Dikicier, Enis AU - Dikicier E AUID- ORCID: 0000-0002-5074-0299 AD - Faculty of Medicine, Department of General Surgery, Sakarya University, Sakarya, Turkey. FAU - Eroz, Erhan AU - Eroz E AUID- ORCID: 0000-0003-1044-1013 AD - Department of General Surgery, Sakarya Training and Research Hospital, Sakarya, Turkey. FAU - Aka, Bahaeddin Umur AU - Aka BU AUID- ORCID: 0000-0002-5757-1846 AD - Department of General Surgery, Sakarya Training and Research Hospital, Sakarya, Turkey. FAU - Tutar, Elif AU - Tutar E AUID- ORCID: 0009-0008-8984-0597 AD - Department of General Surgery, Sakarya Training and Research Hospital, Sakarya, Turkey. FAU - Soydas, Umit AU - Soydas U AUID- ORCID: 0009-0001-2877-6180 AD - Department of General Surgery, Sakarya Training and Research Hospital, Sakarya, Turkey. FAU - Altintoprak, Fatih AU - Altintoprak F AUID- ORCID: 0000-0002-3939-8293 AD - Faculty of Medicine, Department of General Surgery, Sakarya University, Sakarya, Turkey. LA - eng PT - Journal Article DEP - 20251128 PL - England TA - BMC Surg JT - BMC surgery JID - 100968567 SB - IM MH - Humans MH - *Pilonidal Sinus/surgery MH - Male MH - Female MH - Adult MH - *Patient Reported Outcome Measures MH - Retrospective Studies MH - *Laser Therapy/methods MH - Treatment Outcome MH - Young Adult MH - Patient Satisfaction MH - Quality of Life MH - Recurrence MH - *Lasers, Semiconductor/therapeutic use MH - Middle Aged MH - Combined Modality Therapy MH - Adolescent MH - Follow-Up Studies PMC - PMC12661896 OTO - NOTNLM OT - Diode laser ablation OT - Minimally invasive surgery OT - Patient satisfaction OT - Patient-Reported outcomes measurement information system (PROMIS) OT - Pilonidal sinus disease OT - Pit excision OT - Quality of recovery-15 (QoR-15) OT - Recurrence prediction OT - Short assessment of patient satisfaction (SAPS) COIS- Declarations. Ethics approval and consent to participate: This non-interventional retrospective study was approved by the Non-Interventional Ethics Committee of the Faculty of Medicine, Sakarya University (Approval No. E-71522473-050.04 -364065) The requirement for written informed consent was waived by the committee due to the study's retrospective design. Consent for publication: Not applicable. This manuscript does not contain any individual person's data (including videos, or identifying details). Competing interests: The authors declare no competing interests. EDAT- 2025/11/29 06:28 MHDA- 2025/11/29 06:29 PMCR- 2025/11/28 CRDT- 2025/11/29 00:46 PHST- 2025/07/18 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2025/11/29 06:29 [medline] PHST- 2025/11/29 06:28 [pubmed] PHST- 2025/11/29 00:46 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - 10.1186/s12893-025-03319-4 [pii] AID - 3319 [pii] AID - 10.1186/s12893-025-03319-4 [doi] PST - epublish SO - BMC Surg. 2025 Nov 28;25(1):576. doi: 10.1186/s12893-025-03319-4. PMID- 41316041 OWN - NLM STAT- MEDLINE DCOM- 20251230 LR - 20260625 IS - 1471-2342 (Electronic) IS - 1471-2342 (Linking) VI - 25 IP - 1 DP - 2025 Nov 28 TI - CT-assessed pectoralis major muscle measurements as risk factors for low neoadjuvant chemotherapy efficacy in osteosarcoma: a retrospective study. PG - 530 LID - 10.1186/s12880-025-02087-0 [doi] LID - 530 AB - BACKGROUND: Neoadjuvant chemotherapy (NAC) response in terms of tumor necrosis for osteosarcoma is of clinical significance for subsequent treatment, CT-acquired parameters indicating sarcopenia were reported to be the risk factors of low NAC efficacy in a variety of malignant tumors, yet the association between chest CT-derived pectoralis major muscle measurements and tumor necrosis of osteosarcoma have not been revealed. METHODS: The pectoralis major muscle area, normalized pectoralis major muscle index (PMI) and CT attenuation acquired from preoperative chest CT as well as clinical data of 131 osteosarcoma patients were retrospectively analyzed and compared between favorable NAC response (tumor necrosis >/= 90%) and poor NAC response group (tumor necrosis < 90%). For the evaluation of interobserver reproducibility, interclass correlation coefficient (ICC) with 95% confidence interval (CI) was used. The receiver operating characteristic (ROC) analysis was performed to determine the efficiency of each measurement and to calculate the optimal cut-off values of significant parameters. Multivariable binary logistic regression analysis was performed to determine the risk factors of low NAC efficacy. RESULTS: A total of 79 lesions from 78 patients were eligible for this study (mean age, 17.6 +/- 0.9 years; 45 male), 34 lesions constituted the favorable response (FR) group and 45 lesions constituted the poor response (PR) group. Pectoralis major muscle measurements were significantly higher in FR group than in PR group (muscle area, 11.56 +/- 4.48 VS 9.42 +/- 3.57, P = 0.021; PMI, 7.32 +/- 2.23 VS 5.64 +/- 1.54, P < 0.001; CT attenuation, 38.78 +/- 8.44 VS 31.96 +/- 11.37, P = 0.004). Excellent interobserver agreement was found in these parameters with ICC values ranging 0.925-0.944. In ROC analysis, PMI showed an area under curve (AUC) of 0.727, 95% CI: 0.612, 0.842, the threshold value for differentiating FR from PR was 7.147. PMI were risk factors of low NAC efficacy with the P value of 0.007. CONCLUSIONS: Chest CT-accessed pectoralis major muscle area, PMI and CT attenuation were significantly correlated with tumor necrosis in osteosarcoma, these can be potentially helpful imaging auxiliary biomarkers for predicting NAC response of osteosarcoma. CI - (c) 2025. The Author(s). FAU - Li, Zhijun AU - Li Z AD - Department of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - Tianjin's Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - Key Laboratory of Cancer Prevention and Therapy, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. FAU - Zhang, Yaodan AU - Zhang Y AD - Department of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - Tianjin's Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - Key Laboratory of Cancer Prevention and Therapy, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. FAU - Wu, Haixiao AU - Wu H AD - Tianjin's Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - Key Laboratory of Cancer Prevention and Therapy, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - Department of Bone and Soft Tissue Tumors, Cancer Institute & Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. FAU - Zhang, Chao AU - Zhang C AD - Tianjin's Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - Key Laboratory of Cancer Prevention and Therapy, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. AD - Department of Bone and Soft Tissue Tumors, Cancer Institute & Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. FAU - Ye, Zhaoxiang AU - Ye Z AD - Department of Radiology, Tianjin Medical University Cancer Institute & Hospital, National Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. yezhaoxiang@163.com. AD - Tianjin's Clinical Research Center for Cancer, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. yezhaoxiang@163.com. AD - State Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. yezhaoxiang@163.com. AD - Key Laboratory of Cancer Prevention and Therapy, Huan‑Hu‑Xi Road, Ti‑Yuan‑Bei, Hexi District, Tianjin, 300060, China. yezhaoxiang@163.com. LA - eng GR - TJYXZDXK-009A/Tianjin Key Medical Discipline (Specialty) Construction Project/ GR - 2021YFC2500400/The Chinese National Key Research and Development Project/ PT - Journal Article DEP - 20251128 PL - England TA - BMC Med Imaging JT - BMC medical imaging JID - 100968553 SB - IM MH - Humans MH - Male MH - *Osteosarcoma/drug therapy/diagnostic imaging/pathology MH - Female MH - Retrospective Studies MH - *Pectoralis Muscles/diagnostic imaging/pathology MH - *Neoadjuvant Therapy MH - Risk Factors MH - *Tomography, X-Ray Computed/methods MH - Adolescent MH - *Bone Neoplasms/drug therapy/diagnostic imaging/pathology MH - Young Adult MH - Child MH - Sarcopenia/diagnostic imaging MH - ROC Curve MH - Adult PMC - PMC12751793 OTO - NOTNLM OT - Body composition OT - Computed tomography OT - Neoadjuvant chemotherapy OT - Osteosarcoma OT - Sarcopenia COIS- Declarations. Ethics approval and consent to participate: The present study was in accordance with the Declaration of Helsinki. This retrospective study was approved by the institutional review board of Tianjin Medical University and the requirement to obtain informed consent was waived (clinical trial: bc2021011). Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/29 06:28 MHDA- 2025/12/31 06:13 PMCR- 2025/11/28 CRDT- 2025/11/29 00:43 PHST- 2024/09/08 00:00 [received] PHST- 2025/11/24 00:00 [accepted] PHST- 2025/12/31 06:13 [medline] PHST- 2025/11/29 06:28 [pubmed] PHST- 2025/11/29 00:43 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - 10.1186/s12880-025-02087-0 [pii] AID - 2087 [pii] AID - 10.1186/s12880-025-02087-0 [doi] PST - epublish SO - BMC Med Imaging. 2025 Nov 28;25(1):530. doi: 10.1186/s12880-025-02087-0. PMID- 41315103 OWN - NLM STAT- MEDLINE DCOM- 20260309 LR - 20260813 IS - 1432-198X (Electronic) IS - 0931-041X (Print) IS - 0931-041X (Linking) VI - 41 IP - 4 DP - 2026 Apr TI - Suppressor of cytokine signaling 2 is associated with growth impairment in pediatric chronic kidney disease. PG - 1151-1159 LID - 10.1007/s00467-025-07029-0 [doi] AB - BACKGROUND: Growth failure is a common and serious complication of chronic kidney disease (CKD) in children, resulting from numerous factors, including growth hormone (GH) resistance. Suppressor of cytokine signaling 2 (SOCS2), a negative regulator of GH signaling, has been implicated in growth regulation but has not been previously studied in pediatric CKD. METHODS: In this cross-sectional study, we assessed serum SOCS2 concentrations in 55 children with CKD (stages 2-5) and 27 age- and sex-matched healthy controls using a high-sensitivity ELISA. We evaluated anthropometric parameters, kidney function, and biochemical markers. Associations between SOCS2 levels and growth (height standard deviation scores, HtSDS) were analyzed using correlation and multivariate regression models. RESULTS: SOCS2 levels were significantly higher in children with CKD compared to controls (median 1526.5 vs. 1294.6 pg/ml, p < 0.001). In patients with CKD, SOCS2 negatively correlated with HtSDS (r = -0.30, p = 0.029). In multivariate analysis, SOCS2 was an independent predictor of lower HtSDS alongside eGFR. SOCS2 concentrations were higher in short-statured children, and ROC analysis showed acceptable diagnostic performance for predicting short stature (AUC 0.78, 95% CI 0.64-0.91; 79.5% sensitivity, 68.8% specificity). CONCLUSIONS: Circulating SOCS2 levels are elevated in pediatric CKD and independently associated with growth impairment, suggesting its potential link to GH resistance, which is typical of CKD. SOCS2 might be a potential new marker of growth retardation. Further longitudinal studies are needed to explore its predictive value for longitudinal growth and GH treatment response. CI - (c) 2025. The Author(s). FAU - Deja, Anna AU - Deja A AUID- ORCID: 0000-0002-9901-4140 AD - Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland. anna.deja@wum.edu.pl. AD - Doctoral School, Medical University of Warsaw, Warsaw, Poland. anna.deja@wum.edu.pl. FAU - Leszczynska, Beata AU - Leszczynska B AD - Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland. FAU - Materny, Nikola AU - Materny N AD - Student Scientific Group, Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland. FAU - Wujec, Maja AU - Wujec M AD - Student Scientific Group, Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland. FAU - Stelmaszczyk-Emmel, Anna AU - Stelmaszczyk-Emmel A AD - Department of Laboratory Diagnostics and Clinical Immunology Developmental Age, Medical University of Warsaw, Warsaw, Poland. FAU - Panczyk-Tomaszewska, Malgorzata AU - Panczyk-Tomaszewska M AD - Department of Pediatrics and Nephrology, Medical University of Warsaw, Warsaw, Poland. LA - eng PT - Journal Article DEP - 20251128 PL - Germany TA - Pediatr Nephrol JT - Pediatric nephrology (Berlin, Germany) JID - 8708728 RN - 0 (SOCS2 protein, human) RN - 0 (Suppressor of Cytokine Signaling Proteins) RN - 0 (Biomarkers) RN - 9002-72-6 (Growth Hormone) SB - IM MH - Cross-Sectional Studies MH - *Renal Insufficiency, Chronic/blood/complications/genetics MH - Case-Control Studies MH - *Suppressor of Cytokine Signaling Proteins/blood MH - *Growth Disorders/blood/diagnosis/genetics MH - Biomarkers/blood MH - ROC Curve MH - Predictive Value of Tests MH - Growth Hormone/blood MH - Humans MH - Male MH - Female MH - Child, Preschool MH - Child MH - Anthropometry MH - Body Height PMC - PMC12953468 OTO - NOTNLM OT - Children OT - Chronic kidney disease OT - Growth impairment OT - SOCS2 OT - Subclinical inflammation COIS- Declarations. Competing interests: The authors declare no competing interests. EDAT- 2025/11/29 02:21 MHDA- 2026/03/07 16:16 PMCR- 2025/11/28 CRDT- 2025/11/28 23:31 PHST- 2025/07/06 00:00 [received] PHST- 2025/10/10 00:00 [accepted] PHST- 2025/09/20 00:00 [revised] PHST- 2026/03/07 16:16 [medline] PHST- 2025/11/29 02:21 [pubmed] PHST- 2025/11/28 23:31 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - 10.1007/s00467-025-07029-0 [pii] AID - 7029 [pii] AID - 10.1007/s00467-025-07029-0 [doi] PST - ppublish SO - Pediatr Nephrol. 2026 Apr;41(4):1151-1159. doi: 10.1007/s00467-025-07029-0. Epub 2025 Nov 28. PMID- 41314834 OWN - NLM STAT- MEDLINE DCOM- 20251128 LR - 20251203 IS - 2044-6055 (Electronic) IS - 2044-6055 (Linking) VI - 15 IP - 11 DP - 2025 Nov 28 TI - Is Cardiovascular Mortality Among People with Epilepsy increasing? A retrospective US population study. PG - e095195 LID - 10.1136/bmjopen-2024-095195 [doi] LID - e095195 AB - INTRODUCTION: People with epilepsy are at higher risk for hypertension, diabetes, hyperlipidaemia and obesity than the US general population. It is unknown whether these risk factors translate to increased cardiovascular mortality compared with the US general population. OBJECTIVE: To examine changes in the proportions of deaths due to cardiovascular causes among people with epilepsy in the USA. HYPOTHESIS: Cardiovascular mortality among people with epilepsy is rising in the USA compared with the general population over the period from 2000 to 2019. DESIGN/METHODS: Retrospective, longitudinal US population study of all deaths among people with epilepsy due to cardiovascular causes compared with the US general population for the years 2000 through 2019. Source data were obtained from the Centers for Disease Control and Prevention (CDC) Multiple Cause of Death Database using all International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10) codes for epilepsy (specifically all ICD-10 codes G40.0 through G40.919). The use of administrative datasets, like the CDC Multiple Cause Of Death Database, is a validated method that effectively captures US epilepsy mortality when using the ICD-10 codes G40.0-G40.9. Cardiovascular deaths were operationally defined as ischaemic heart disease, cerebrovascular disease, diabetes and hypertension. Data were stratified by age, race and gender. Relative proportions of each cause of death were expressed as a percentage of total deaths and evaluated on the log-odds scale using a logistic regression model. Standardised proportions were also used and reported. PRIMARY AND SECONDARY OUTCOMES: Within-group and between-group differences in the rate/proportions of deaths due to cerebrovascular disease, ischaemic heart disease, diabetes and hypertension among people with epilepsy and the general population over a 20-year period. SETTING: US epilepsy and general populations. RESULTS: Age-adjusted mortality for cerebrovascular disease and diabetes increased significantly among people with epilepsy compared with the US general population over the 20-year period (p<0.001). Age-stratified comparisons indicate that the proportions of deaths due to cerebrovascular disease and diabetes increased significantly among people with epilepsy compared with the general population aged 35-64 years. An unexpected finding is a trend reversal in the proportions of deaths from ischaemic heart disease among people with epilepsy. Prior to 2011, the proportion of deaths due to ischaemic heart disease among people with epilepsy declined steadily at a slope of -0.265 annually. After 2011, the slope changed from -0.265 to virtually zero in contrast to the continued decline in the US general population (epilepsy vs general population slope difference: p<0.001 after the breakpoint year). CONCLUSIONS: Age-standardised proportions of deaths attributed to cerebrovascular disease and diabetes increased significantly among people with epilepsy from 2000 to 2019. Age-stratified proportions of deaths due to cerebrovascular disease and diabetes occurred primarily in the 35-64-year age range. The long decline in the proportions of deaths due to ischaemic heart disease among people with epilepsy ended after 2011, despite continuing to decline in the general population. The increase in proportions of cardiovascular deaths among people with epilepsy is likely due to higher cardiovascular risk factors compared with the general US population. Increased surveillance and treatment of cardiovascular risk factors among people with epilepsy are indicated, especially in the critical 35-64-year age group, where improved primary prevention may reduce cardiovascular risk and mortality. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Curtis, Ashley AU - Curtis A AD - California University of Science and Medicine, Colton, California, USA. FAU - Markovic, Daniela AU - Markovic D AD - UCLA, Los Angeles, California, USA. FAU - Liao, Andrew AU - Liao A AD - California University of Science and Medicine, Colton, California, USA. FAU - Ganapa, Somnath AU - Ganapa S AD - Medicine, UCLA, Los Angeles, California, USA. FAU - Gaertner, Mark AU - Gaertner M AD - Neurology, UCLA, Los Angeles, California, USA. FAU - DeGiorgio, Christopher M AU - DeGiorgio CM AUID- ORCID: 0000-0002-9863-9069 AD - Neurology, UCLA, Los Angeles, California, USA cmd@mednet.ucla.edu. LA - eng PT - Journal Article DEP - 20251128 PL - England TA - BMJ Open JT - BMJ open JID - 101552874 SB - IM MH - Humans MH - *Epilepsy/complications/mortality/epidemiology MH - Female MH - Retrospective Studies MH - Male MH - United States/epidemiology MH - *Cardiovascular Diseases/mortality MH - Middle Aged MH - Adult MH - Aged MH - Longitudinal Studies MH - Cause of Death/trends MH - Young Adult MH - Hypertension/mortality MH - Risk Factors MH - Adolescent PMC - PMC12666228 OTO - NOTNLM OT - Cardiovascular Disease OT - Epilepsy OT - Hypertension OT - Mortality OT - Risk Factors OT - Stroke COIS- Competing interests: None declared. EDAT- 2025/11/29 02:21 MHDA- 2025/11/29 02:22 PMCR- 2025/11/28 CRDT- 2025/11/28 21:43 PHST- 2025/11/29 02:22 [medline] PHST- 2025/11/29 02:21 [pubmed] PHST- 2025/11/28 21:43 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - bmjopen-2024-095195 [pii] AID - 10.1136/bmjopen-2024-095195 [doi] PST - epublish SO - BMJ Open. 2025 Nov 28;15(11):e095195. doi: 10.1136/bmjopen-2024-095195. PMID- 41314793 OWN - NLM STAT- MEDLINE DCOM- 20260313 LR - 20260313 IS - 1468-330X (Electronic) IS - 0022-3050 (Linking) VI - 97 IP - 4 DP - 2026 Mar 13 TI - Vitamin D intake and multiple sclerosis risk in the Norwegian Mother, Father and Child cohort. PG - 309-315 LID - 10.1136/jnnp-2025-337300 [doi] AB - BACKGROUND: Higher vitamin D has consistently been associated with a lower multiple sclerosis (MS) risk, but some controversy remains about whether this is due to vitamin D itself or sunlight. METHODS: We conducted a prospective study among women participating in the Norwegian Mother, Father and Child Cohort Study, recruited in 2002-2008 and followed until 2022. We identified incident MS cases through data linkage with the Norwegian MS Registry. Total vitamin D intake from food and supplements was obtained from validated food frequency questionnaires completed in pregnancy. We estimated HRs for MS and 95% confidence intervals (CI) using Cox regression. RESULTS: Among 78 074 participants, 349 developed MS during follow-up. Their median daily vitamin D intake was 296 international units (IU) compared with 333 IU among women who did not develop MS. Higher total vitamin D intake was associated with a 42% lower MS risk (HR comparing top vs bottom quintile 0.58, 95% CI 0.38 to 0.89, p(trend)<0.01). The results were similar when adjusting for age at delivery, total energy intake, pre-pregnancy body mass index and smoking. The associations were similar for vitamin D intake from food (HR for top vs bottom quintile 0.70, 95% CI 0.47 to 0.1.04, p(trend)=0.02) and supplements (HR for >/=600 IU/day vs <200 IU/day 0.65, 95% CI 0.41 to 1.04, p(trend)=0.01). CONCLUSIONS: In this prospective study, higher vitamin D intake was associated with lower MS risk in women living in Norway, where there is insufficient sun-induced vitamin D production during most of the year. This supports the hypothesis that vitamin D itself modifies MS risk. CI - (c) Author(s) (or their employer(s)) 2026. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - Kapali, Akash AU - Kapali A AUID- ORCID: 0000-0002-0581-4981 AD - Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. AD - Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway. FAU - Daltveit, Anne Kjersti AU - Daltveit AK AD - Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. AD - Department of Health Registry Research and Development, Norwegian Institute of Public Health, Bergen, Norway. FAU - Myhr, Kjell-Morten AU - Myhr KM AD - Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway. AD - Department of Clinical Medicine, University of Bergen, Bergen, Norway. FAU - Bjornevik, Kjetil AU - Bjornevik K AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. AD - Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. FAU - Eid, Karine AU - Eid K AUID- ORCID: 0000-0002-5158-7636 AD - Department of Clinical Medicine, University of Bergen, Bergen, Norway. AD - Department of Neurology, Haukeland University Hospital, Bergen, Norway. FAU - Bjork, Marte-Helene AU - Bjork MH AD - Department of Clinical Medicine, University of Bergen, Bergen, Norway. AD - Department of Neurology, Haukeland University Hospital, Bergen, Norway. FAU - Brantsaeter, Anne Lise AU - Brantsaeter AL AUID- ORCID: 0000-0001-6315-7134 AD - Department of Food Safety, Norwegian Institute of Public Health, Oslo, Norway. AD - Centre for Sustainable Diets, Norwegian Institute of Public Health, Oslo, Norway. FAU - Riise, Trond AU - Riise T AUID- ORCID: 0000-0001-9644-5140 AD - Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway. AD - Neuro-SysMed, Department of Neurology, Haukeland University Hospital, Bergen, Norway. FAU - Cortese, Marianna AU - Cortese M AUID- ORCID: 0000-0002-3665-2006 AD - Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA marianna.cortese@uib.no. LA - eng PT - Journal Article DEP - 20260313 PL - England TA - J Neurol Neurosurg Psychiatry JT - Journal of neurology, neurosurgery, and psychiatry JID - 2985191R RN - 1406-16-2 (Vitamin D) SB - IM MH - Humans MH - *Multiple Sclerosis/epidemiology MH - *Vitamin D/administration & dosage MH - Female MH - Norway/epidemiology MH - Adult MH - Prospective Studies MH - Male MH - Dietary Supplements MH - Risk Factors MH - Pregnancy MH - Middle Aged MH - Cohort Studies MH - Mothers MH - Fathers OTO - NOTNLM OT - EPIDEMIOLOGY OT - MULTIPLE SCLEROSIS COIS- Competing interests: AK, AKD, K-MM, KB, KE, ALB, TR and MC report no competing interests. M-HB reported institutional payment from the Marked authorisation holders of valproate (Sanofi, Desitin and more) for the conduction of a post-authorisation safety study and lecture honouraria from Eisai, AbbVie, Angelini Pharma, Novartis, Pfizer, BestPractice and Organon and advisory board honouraria from Jazz Pharmaceuticals, Angelini Pharma, Lundbeck, Pfizer and Eisai, none related to the present topic. EDAT- 2025/11/29 02:21 MHDA- 2026/03/14 00:31 CRDT- 2025/11/28 21:23 PHST- 2025/08/04 00:00 [received] PHST- 2025/11/04 00:00 [accepted] PHST- 2026/03/14 00:31 [medline] PHST- 2025/11/29 02:21 [pubmed] PHST- 2025/11/28 21:23 [entrez] AID - jnnp-2025-337300 [pii] AID - 10.1136/jnnp-2025-337300 [doi] PST - epublish SO - J Neurol Neurosurg Psychiatry. 2026 Mar 13;97(4):309-315. doi: 10.1136/jnnp-2025-337300. PMID- 41314678 OWN - NLM STAT- MEDLINE DCOM- 20251128 LR - 20251203 IS - 2399-9772 (Electronic) IS - 2399-9772 (Linking) VI - 9 IP - 1 DP - 2025 Nov 27 TI - Cost analysis of probiotic/synbiotic supplementation in infants in rural Kenya: a study from the PROSYNK trial. LID - 10.1136/bmjpo-2025-003635 [doi] LID - e003635 AB - BACKGROUND: Undernutrition significantly contributes to infant mortality and underlies approximately 45% of global deaths in children under 5, making it one of the most concerning global child health issues. The PRObiotics and SYNbiotics in infants in Kenya (PROSYNK) trial is assessing whether supervised pro/synbiotic doses daily for the first 10 days and then weekly to age 6 months has a positive impact on gut health and thereby growth and nutrition. This study provides a cost analysis of the PROSYNK trial, estimates the costs of implementing the intervention, and offers feasability insights for delivering it to infants 0-5 months in rural Kenya. METHODS: This provider perspective costing study used a combination of the ingredients approach, activity-based costing and microcosting. First, an empirical cost analysis of the PROSYNK trial was conducted by review of trial documentation and time and motion observations. Next, semistructured interviews with key informants informed a thematic analysis of implementation feasibility and the development of a theoretical programme structure, which formed the basis for estimating total economic programme costs. RESULTS: The economic cost of delivering the full pro/synbiotics course under trial conditions was measured as US$701.61 per participant. Experience gained during PROSYNK and discussions with key informants suggest that it could be feasible for the Ministry of Health (MoH) to implement programmatic delivery of the pro/synbiotics, particularly through community-based delivery, without a cold chain and with pro/synbiotic administered directly into infants' mouths. Incremental economic costs to the MoH of delivering the pro/synbiotic programmatically were estimated to be US$9.14 per infant per full course under the baseline scenario. CONCLUSION: Pro/synbiotic administration in early life may be feasible and bear similar costs to existing nutrition interventions. This study will provide policy makers and stakeholders with cost and feasibility insights to inform effective programmatic implementation in Kenya and similar settings. CI - (c) Author(s) (or their employer(s)) 2025. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ Group. FAU - McCallum, Beth AU - McCallum B AUID- ORCID: 0000-0001-9965-719X AD - Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, England, UK bethmccallum@gmail.com. FAU - Iwaret Otiti, Mary AU - Iwaret Otiti M AUID- ORCID: 0000-0002-5514-6846 AD - Kenya Medical Research Institute, Nairobi, Nairobi County, Kenya. FAU - Achieng, Florence AU - Achieng F AD - Kenya Medical Research Institute, Nairobi, Nairobi County, Kenya. FAU - Allen, Stephen AU - Allen S AUID- ORCID: 0000-0001-6675-249X AD - Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, England, UK. FAU - Worrall, Eve AU - Worrall E AUID- ORCID: 0000-0001-9147-3388 AD - Department of Clinical Sciences, Liverpool School of Tropical Medicine, Liverpool, England, UK. LA - eng PT - Journal Article DEP - 20251127 PL - England TA - BMJ Paediatr Open JT - BMJ paediatrics open JID - 101715309 SB - IM MH - Humans MH - Kenya MH - *Probiotics/economics/administration & dosage/therapeutic use MH - Infant MH - Rural Population MH - *Synbiotics/economics/administration & dosage MH - Infant, Newborn MH - *Dietary Supplements/economics MH - Costs and Cost Analysis MH - Female MH - Male PMC - PMC12666201 OTO - NOTNLM OT - Costing OT - Developing Countries OT - Growth OT - Health Policy OT - Low and Middle Income Countries COIS- Competing interests: No, there are no competing interests. EDAT- 2025/11/29 02:21 MHDA- 2025/11/29 02:22 PMCR- 2025/11/27 CRDT- 2025/11/28 20:43 PHST- 2025/05/06 00:00 [received] PHST- 2025/11/04 00:00 [accepted] PHST- 2025/11/29 02:22 [medline] PHST- 2025/11/29 02:21 [pubmed] PHST- 2025/11/28 20:43 [entrez] PHST- 2025/11/27 00:00 [pmc-release] AID - 10.1136/bmjpo-2025-003635 [pii] AID - bmjpo-2025-003635 [pii] AID - 10.1136/bmjpo-2025-003635 [doi] PST - epublish SO - BMJ Paediatr Open. 2025 Nov 27;9(1):e003635. doi: 10.1136/bmjpo-2025-003635. PMID- 41314287 OWN - NLM STAT- MEDLINE DCOM- 20260703 LR - 20260703 IS - 2253-8089 (Electronic) IS - 2253-8089 (Linking) VI - 45 IP - 4 DP - 2026 Jul-Aug TI - Clinical contribution of (18)F-FDG PET/CT in patients with pediatric bone tissue and soft tissue sarcoma; a retrospective study. PG - 500252 LID - S2253-8089(25)00160-0 [pii] LID - 10.1016/j.remnie.2025.500252 [doi] AB - OBJECTIVE: To assess whether parameters derived from (1)(8)F-FDG PET/CT imaging could be used for prognostic evaluation in pediatric patients with bone and soft tissue sarcomas. MATERIAL AND METHODS: This retrospective study included pediatric patients diagnosed with sarcoma who underwent (1)(8)F-FDG PET/CT between February 2013 and January 2021. A total of 63 patients were evaluated. Anatomical tumor volume, standardized uptake values (SUV), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured. Progression-free survival (PFS) and overall survival (OS) were calculated. Cox regression analysis was performed to identify independent predictors. RESULTS: The mortality rate was 31.7%, and the median OS was 54.9 months. Lung (p<0.001) and lymph node metastases (p=0.049) were associated with shorter OS. Younger age at diagnosis (p=0.014), higher anatomical tumor volume (p=0.002), and lung metastasis (p=0.004) were independently associated with increased mortality risk. High MTV was independently associated with higher progression risk (p<0.001). CONCLUSION: Anatomical tumor volume and lung metastasis predict mortality, while MTV predicts progression in pediatric sarcoma. Further prospective studies are needed to validate these findings. CI - Copyright (c) 2025 Sociedad Espanola de Medicina Nuclear e Imagen Molecular. Published by Elsevier Espana, S.L.U. All rights reserved. FAU - Engin, M N AU - Engin MN AD - Akdeniz University Faculty of Medicine Department of Nuclear Medicine, Antalya, Turkey. Electronic address: mugennkk@gmail.com. FAU - Bural, G G AU - Bural GG AD - Akdeniz University Faculty of Medicine Department of Nuclear Medicine, Antalya, Turkey. FAU - Guler, E AU - Guler E AD - Akdeniz University Faculty of Medicine, Department of Pediatric Oncology, Antalya, Turkey. FAU - Boz, A AU - Boz A AD - Akdeniz University Faculty of Medicine Department of Nuclear Medicine, Antalya, Turkey. LA - eng PT - Journal Article DEP - 20251126 PL - Spain TA - Rev Esp Med Nucl Imagen Mol (Engl Ed) JT - Revista espanola de medicina nuclear e imagen molecular JID - 101770941 RN - 0Z5B2CJX4D (Fluorodeoxyglucose F18) RN - 0 (Radiopharmaceuticals) SB - IM MH - Humans MH - Retrospective Studies MH - *Fluorodeoxyglucose F18 MH - *Positron Emission Tomography Computed Tomography/methods MH - Female MH - Child MH - Male MH - *Bone Neoplasms/diagnostic imaging/mortality/pathology/metabolism MH - *Sarcoma/diagnostic imaging/mortality/pathology/metabolism MH - *Radiopharmaceuticals MH - Adolescent MH - Child, Preschool MH - Prognosis MH - Tumor Burden MH - *Soft Tissue Neoplasms/diagnostic imaging/mortality MH - Lung Neoplasms/secondary/diagnostic imaging MH - Lymphatic Metastasis OTO - NOTNLM OT - (18)F-FDG OT - Child OT - Pediatria OT - Positron emission tomography OT - Prognosis OT - Pronostico OT - Sarcoma OT - Supervivencia OT - Survival OT - Tomografia por emision de positrones EDAT- 2025/11/29 02:21 MHDA- 2026/07/04 00:33 CRDT- 2025/11/28 19:13 PHST- 2025/03/25 00:00 [received] PHST- 2025/09/10 00:00 [revised] PHST- 2025/09/15 00:00 [accepted] PHST- 2026/07/04 00:33 [medline] PHST- 2025/11/29 02:21 [pubmed] PHST- 2025/11/28 19:13 [entrez] AID - S2253-8089(25)00160-0 [pii] AID - 10.1016/j.remnie.2025.500252 [doi] PST - ppublish SO - Rev Esp Med Nucl Imagen Mol (Engl Ed). 2026 Jul-Aug;45(4):500252. doi: 10.1016/j.remnie.2025.500252. Epub 2025 Nov 26. PMID- 41314055 OWN - NLM STAT- MEDLINE DCOM- 20260109 LR - 20260814 IS - 1879-0046 (Electronic) IS - 0376-8716 (Print) IS - 0376-8716 (Linking) VI - 278 DP - 2026 Jan 1 TI - Optimizing measures of drinking to predict alcohol-related consequences. PG - 112973 LID - S0376-8716(25)00426-0 [pii] LID - 10.1016/j.drugalcdep.2025.112973 [doi] AB - BACKGROUND: Alcohol use surges in late adolescence, particularly among college students, and is associated with a wide variety of negative socio-emotional, academic, legal, and health consequences. Although most studies assess risk for these consequences through self-report of drinking quantity and frequency, ample evidence indicates that youth who drink alcohol can be inaccurate in reporting their drinking behavior and that estimates become increasingly biased as drinking increases. In the current study, we examined two approaches for optimizing self-reported alcohol consumption estimates to assess associations with drinking consequences. BASIC PROCEDURE: The primary sample included 572 college students (53.9 % female; 18-23 age; 61.4 % White, 20.5 % Black, and 18.1 % additional racial-ethnic groups) who completed surveys and a standard lab-based free-pour knowledge task. We tested associations between consumption and consequences (as moderated by body mass index) using both multiple regression with covariates and instrumental variable analyses. MAIN FINDINGS: Indicators of inaccuracy in self-reported consumption met requirements for serving as instrumental variables. In all models, consumption and consequences were strongly associated, though predictive validity measures differed in which technique they favored. Consumption rates only predicted consequences when body mass index was less than ~34 (obesity class 1). CONCLUSIONS: Our results demonstrate that including assessments of reporting inaccuracy, alcohol knowledge, and body mass index when studying alcohol consumption may be important for reducing bias due to measurement error and predicting consequences of alcohol use. CI - Copyright (c) 2025 Elsevier B.V. All rights reserved. FAU - Hussong, Andrea M AU - Hussong AM AD - University of North Carolina at Chapel Hill, CB#3270 Davie Hall, UNC-CH, Chapel Hill, NC 27599-3270, USA. Electronic address: hussong@unc.edu. FAU - Traver, Jennifer M AU - Traver JM AD - University of North Carolina at Chapel Hill, CB#3270 Davie Hall, UNC-CH, Chapel Hill, NC 27599-3270, USA. Electronic address: jmtraver@unc.edu. LA - eng GR - R01 DA034636/DA/NIDA NIH HHS/United States PT - Journal Article DEP - 20251120 PL - Ireland TA - Drug Alcohol Depend JT - Drug and alcohol dependence JID - 7513587 SB - IM MH - Humans MH - Female MH - Male MH - Adolescent MH - Young Adult MH - *Alcohol Drinking/psychology/epidemiology/adverse effects MH - *Self Report/standards MH - Students/psychology MH - *Alcohol Drinking in College/psychology MH - Body Mass Index MH - Universities PMC - PMC12677144 MID - NIHMS2126062 OTO - NOTNLM OT - Alcohol OT - Alcohol Consumption OT - Alcohol consequences OT - Bias OT - Measurement COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/11/29 02:21 MHDA- 2026/01/10 00:34 PMCR- 2026/11/20 CRDT- 2025/11/28 18:08 PHST- 2025/03/03 00:00 [received] PHST- 2025/11/09 00:00 [revised] PHST- 2025/11/17 00:00 [accepted] PHST- 2026/01/10 00:34 [medline] PHST- 2025/11/29 02:21 [pubmed] PHST- 2025/11/28 18:08 [entrez] PHST- 2026/11/20 00:00 [pmc-release] AID - S0376-8716(25)00426-0 [pii] AID - 10.1016/j.drugalcdep.2025.112973 [doi] PST - ppublish SO - Drug Alcohol Depend. 2026 Jan 1;278:112973. doi: 10.1016/j.drugalcdep.2025.112973. Epub 2025 Nov 20. PMID- 41313348 OWN - NLM STAT- MEDLINE DCOM- 20261022 LR - 20261027 IS - 1432-1971 (Electronic) IS - 0172-0643 (Linking) VI - 47 IP - 8 DP - 2026 Dec TI - Physician Preparedness for Managing Juvenile Obesity in the MENA Region: A Cross-Sectional Analysis of Perceptions, Knowledge, Practices, and Barriers. PG - 3342-3353 LID - 10.1007/s00246-025-04121-y [doi] AB - This study aimed to evaluate physicians' preparedness to manage juvenile obesity (JO) in the Middle East and North Africa (MENA) region by assessing their attitudes, knowledge, clinical practices, confidence, and perceived barriers. A 38-question cross-sectional survey was created, validated, and distributed in December 2024 across MENA countries using a skip-logic-tailored, bilingual (Arabic/English) online platform. It assessed physicians' attitudes, familiarity with JO-management guidelines and concepts, screening and treatment practices, prior JO-training, confidence, and barriers. Data were analyzed using both descriptive and inferential statistics. The study included 400 physicians (54% female, 57% younger than 35, 65% primary care physicians). 90% considered JO a routine checkup priority. Two-thirds reported no JO-training; half were unfamiliar with JO-management guidelines, and 45-65% were unfamiliar with JO-management concepts. Screening was suboptimal, with 25% relying exclusively on visual assessment. Behavioral therapy (33%) and pharmacologic treatments (17%) were underutilized. Most (73%) reported low to moderate confidence in managing JO. Confidence was significantly associated with guideline awareness and recent JO-training. Guideline awareness was also associated with recent JO-training. Physicians aware of guidelines were more likely to applying evidence-based practices (p < 0.001). Majoy selected barriers included lack of JO-training, institutional limitations, and socio-cultural factors. Physicians in MENA face deficits in JO-training, JO-management guidelines awareness, and systemic support that limit confidence in JO management. Expanding JO-training, disseminating regionally-suitable guidelines, and enhancing institutional support are essential to improving physician preparedness for JO management. CI - (c) 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. FAU - Daoud, Ala AU - Daoud A AD - Independent clinical pharmacist (AHPRA registered), Sydney, Australia. AD - , Riyadh, Saudi Arabia. FAU - Qunaibi, Eyad A AU - Qunaibi EA AD - MedOne Academy, Dover, DE, USA. FAU - Raies, Shahem AU - Raies S AD - Otorhinolaryngology Department, Hama National Hospital, Hama, Syria. AD - Al-Andalus University for Medical Sciences, Qadmus, Tartus, Syria. FAU - Altorman, Ula Y AU - Altorman UY AD - Prince Hamza Hospital, Amman, Jordan. AD - Jordan University of Science and Technology, Irbid, Jordan. FAU - Salim, Ahmed AU - Salim A AD - King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia. FAU - Wali, Saad M AU - Wali SM AD - Department of Pharmacology and Toxicology, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia. FAU - Al-Yafeai, Taliaa M AU - Al-Yafeai TM AD - Ras Al Khaimah Medical and Health Sciences University, Ras Al Khaimah, United Arab Emirates. FAU - Alsaied, Tarek AU - Alsaied T AD - Division of Pediatric Cardiology, Children's Medical Center of Dallas, University of Texas Southwestern, Dallas, TX, USA. tarek.alsaied@utsouthwestern.edu. AD - Division of Pediatric Cardiology, UPMC, University of Pittsburgh, Pittsburgh, PA, USA. tarek.alsaied@utsouthwestern.edu. LA - eng PT - Journal Article DEP - 20251128 PL - United States TA - Pediatr Cardiol JT - Pediatric cardiology JID - 8003849 SB - IM MH - Humans MH - Cross-Sectional Studies MH - Female MH - Middle East MH - *Health Knowledge, Attitudes, Practice MH - Male MH - Africa, Northern MH - *Pediatric Obesity/therapy MH - Adult MH - *Practice Patterns, Physicians'/statistics & numerical data MH - *Attitude of Health Personnel MH - Child MH - Surveys and Questionnaires MH - *Clinical Competence OTO - NOTNLM OT - Barriers OT - Childhood obesity OT - Confidence OT - Guideline familiarity OT - Middle east and north africa OT - Pediatric obesity COIS- Declarations. Competing Interests: The authors declare no competing interests. Ethical Approval: Ethical approval was obtained from the Jordan Ministry of Health (No. 19338), Prince Hamzah Hospital (No. 13424), and King Abdullah University Hospital (No. 2024/176/10). The study involved no clinical interventions and was conducted in accordance with the Declaration of Helsinki and its amendments. Consent to Participate: Participation was voluntary, and electronic informed consent was obtained from all participants prior to the initiation of the survey. Participation was anonymous; IP addresses were used solely to detect duplicate entries and were not retained in the analytic dataset. Consent for Publication: Not applicable: the manuscript contains no personal information in any form (text, images, or recordings). Declaration of Generative AI and AI-Assisted Technologies in the Writing Process: During the preparation of this work, the authors utilized ChatGPT (OpenAI, GPT-4, GPT-4.5, and GPT-5) to enhance clarity and refine the language. After using this tool, the authors reviewed and edited the content as needed and take full responsibility for the content of the publication. EDAT- 2025/11/28 13:30 MHDA- 2026/10/22 23:28 CRDT- 2025/11/28 11:02 PHST- 2025/09/13 00:00 [received] PHST- 2025/11/12 00:00 [accepted] PHST- 2026/10/22 23:28 [medline] PHST- 2025/11/28 13:30 [pubmed] PHST- 2025/11/28 11:02 [entrez] AID - 10.1007/s00246-025-04121-y [pii] AID - 10.1007/s00246-025-04121-y [doi] PST - ppublish SO - Pediatr Cardiol. 2026 Dec;47(8):3342-3353. doi: 10.1007/s00246-025-04121-y. Epub 2025 Nov 28. PMID- 41313324 OWN - NLM STAT- MEDLINE DCOM- 20260109 LR - 20260109 IS - 1699-5198 (Electronic) IS - 0212-1611 (Linking) VI - 42 IP - 6 DP - 2026 Jan 9 TI - Sensitivity of body mass index as a current criterion of nutrition: new body mass index redefinition for young adults. PG - 1200-1205 LID - 10.20960/nh.05473 [doi] AB - Introduction: obesity during university studies is becoming a growing problem. In order to recognize health risks in the young population as early as possible, it is important to define objective criteria for obesity. Body mass index (BMI) and percentage of body fat (PBF) are the most common parameters for assessing obesity. Objective: the aim of this research is to determine the criteria of BMI for young university students as a young adult population based on PBF criteria. Methods: this study included 1272 university students, divided by gender (675 females and 597 males). PBF was measured using multichannel bioelectrical impedance analysis InBody 720. Results: percentile distribution was used to establish obesity criteria for PBF based in four categories: athlete, fit, normally nourished and overweight. The results for female showed that the BMI cut-off value for the athlete criterion is 21.97 kg/m2, for the fit criterion is 22.01 kg/m2, for the normally nourished 23.18 kg/m2 and for the overweight 27.29 kg/m2. The results for male showed that for the athlete criterion the cut-off value for BMI was 23.70 kg/m2, for the fit criterion 25.66 kg/m2, for the normally nourished 26.63 kg/m2 and for the overweight 29.60 kg/m2. Conclusion: the existing standard BMI criteria for young adults are not specifically accurate regarding obesity. We propose to redefine BMI nutritional status criteria based on PBF for young adult subjects. FAU - Smrkic, Marko AU - Smrkic M AD - Faculty of Sport and Physical Education. University of Belgrade. FAU - Zlatovic, Igor AU - Zlatovic I AD - Faculty of Sport and Physical Education. University of Belgrade. FAU - Vukadinovic, Nevena AU - Vukadinovic N AD - Faculty of Sport and Physical Education. University of Belgrade. FAU - Koropanovski, Nenad AU - Koropanovski N AD - Department of Criminalistics. University of Criminal Investigation and Police Studies. FAU - Maksimovic, Milos AU - Maksimovic M AD - Institute of Hygiene and Medical Ecology. Faculty of Medicine. University of Belgrade. FAU - Dopsaj, Violeta AU - Dopsaj V AD - Faculty of Pharmacy. University of Belgrade. FAU - Rakic, Sladjana AU - Rakic S AD - Faculty of Physical Education and Sports Management. Singidunum University. FAU - Denic, Lazar AU - Denic L AD - Faculty of Sport and Physical Education. University of Belgrade. FAU - Tomanic, Milena AU - Tomanic M AD - Institute of Hygiene and Medical Ecology. Faculty of Medicine. University of Belgrade. FAU - Ilic, Vladimir AU - Ilic V AD - Institute of Hygiene and Medical Ecology. Faculty of Medicine. University of Belgrade. FAU - Dopsaj, Milivoj AU - Dopsaj M AD - Institute of Hygiene and Medical Ecology. Faculty of Medicine. University of Belgrade. LA - eng PT - Journal Article TT - Sensibilidad del indice de masa corporal como criterio actual de nutricion: nueva redefinicion del indice de masa corporal para adultos jovenes. PL - Spain TA - Nutr Hosp JT - Nutricion hospitalaria JID - 9100365 SB - IM MH - Humans MH - *Body Mass Index MH - Male MH - Female MH - Young Adult MH - *Nutritional Status MH - Obesity/diagnosis MH - Adult MH - Electric Impedance MH - Overweight/diagnosis MH - Body Composition MH - Adolescent MH - Sensitivity and Specificity OTO - NOTNLM OT - Valores de corte. Grasa corporal. Obesidad. Estudiantes. EDAT- 2025/11/28 13:30 MHDA- 2026/01/09 13:33 CRDT- 2025/11/28 10:52 PHST- 2026/01/09 13:33 [medline] PHST- 2025/11/28 13:30 [pubmed] PHST- 2025/11/28 10:52 [entrez] AID - 10.20960/nh.05473 [doi] PST - ppublish SO - Nutr Hosp. 2026 Jan 9;42(6):1200-1205. doi: 10.20960/nh.05473. PMID- 41312254 OWN - NLM STAT- MEDLINE DCOM- 20251128 LR - 20251130 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Eating habits, nutritional status, and lifestyle correlates of body composition in Chinese university students: a cross-sectional study. PG - 1668307 LID - 10.3389/fpubh.2025.1668307 [doi] LID - 1668307 AB - BACKGROUND: Unhealthy eating habits and nutritional imbalances are prevalent among university students and may contribute to hidden obesity and metabolic risk. Understanding the dietary patterns and lifestyle factors associated with body composition is essential for designing effective interventions in this population. OBJECTIVE: This study aimed to assess the dietary habits, nutritional status, and lifestyle correlates of body composition among Chinese university students, with a focus on the prevalence of hidden obesity and low protein mass. METHODS: A cross-sectional survey was conducted among 993 undergraduate students at a major Chinese university. Dietary intake, physical activity, sleep, and other lifestyle factors were assessed using validated questionnaires. Body composition, including body fat percentage and protein status, was measured with a bioelectrical impedance analyzer. Associations between dietary/lifestyle factors and body composition were examined using multivariable regression analyses. RESULTS: Fewer than half of participants reported daily consumption of vegetables, and only 18.2% consumed fruit daily. Hidden obesity, defined as excessive body fat despite normal body mass index, was observed in 17.0% of students, significantly higher among females (23.0%) than males (1.1%) (p < 0.05). Low protein mass, as measured by bioelectrical impedance analysis, was present in 31.0% of students and was more prevalent among females (33.5%) than males (24.6%) (p < 0.05). Weekly fruit intake showed a weak but positive association with both body fat and protein percentages, after adjusting for confounders (p < 0.05). CONCLUSION: Unbalanced dietary patterns, hidden obesity, and low protein mass are widespread among Chinese university students, with sex-specific differences. The relationship between fruit intake and body composition may reflect broader dietary or lifestyle behaviors rather than a direct protective effect. CI - Copyright (c) 2025 Liu, Gong, Li, Zhou and Lin. FAU - Liu, Ling AU - Liu L AD - School of Clinical Medicine, Sichuan College of Traditional Chinese Medicine, Mianyang, Sichuan, China. FAU - Gong, Wan AU - Gong W AD - School of Clinical Medicine, Sichuan College of Traditional Chinese Medicine, Mianyang, Sichuan, China. FAU - Li, Jun AU - Li J AD - School of Clinical Medicine, Sichuan College of Traditional Chinese Medicine, Mianyang, Sichuan, China. FAU - Zhou, Wei AU - Zhou W AD - School of Clinical Medicine, Sichuan College of Traditional Chinese Medicine, Mianyang, Sichuan, China. FAU - Lin, Li AU - Lin L AD - Institute for Nutrition and Food Safety, Sichuan Center for Disease Control and Prevention, Chengdu, Sichuan, China. LA - eng PT - Journal Article PT - Review DEP - 20251112 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Male MH - Female MH - Cross-Sectional Studies MH - *Students/statistics & numerical data MH - *Nutritional Status MH - Universities MH - China/epidemiology MH - *Body Composition MH - *Feeding Behavior MH - *Life Style MH - Young Adult MH - Adult MH - Obesity/epidemiology MH - Surveys and Questionnaires MH - Adolescent PMC - PMC12646914 OTO - NOTNLM OT - dietary habits OT - fruit intake OT - hidden obesity OT - low protein mass OT - nutrition intervention COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/11/28 06:27 MHDA- 2025/11/28 06:28 PMCR- 2025/11/12 CRDT- 2025/11/28 04:47 PHST- 2025/07/17 00:00 [received] PHST- 2025/10/27 00:00 [accepted] PHST- 2025/11/28 06:28 [medline] PHST- 2025/11/28 06:27 [pubmed] PHST- 2025/11/28 04:47 [entrez] PHST- 2025/11/12 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1668307 [doi] PST - epublish SO - Front Public Health. 2025 Nov 12;13:1668307. doi: 10.3389/fpubh.2025.1668307. eCollection 2025. PMID- 41312230 OWN - NLM STAT- MEDLINE DCOM- 20251128 LR - 20251130 IS - 2296-2565 (Electronic) IS - 2296-2565 (Linking) VI - 13 DP - 2025 TI - Psychometric evaluation of the Adult Eating Behavior Questionnaire and its relationship with body mass index among Chinese university students: a cross-sectional validation study. PG - 1691302 LID - 10.3389/fpubh.2025.1691302 [doi] LID - 1691302 AB - BACKGROUND: Eating behavior critically impacts human health and the development of obesity. This study aimed to validate the Adult Eating Behavior Questionnaire (AEBQ) among Chinese university students and explore the relationship between appetitive traits and body mass index (BMI). METHODS: A total of 546 students from Southeast University completed the Chinese version of the AEBQ and self-reported anthropometric data. Confirmatory factor analysis (CFA) was used to test the factor structure and evaluate model fit, and Spearman's correlation assessed relationships between appetitive traits and BMI. RESULTS: The original 8-factor, 35-item model showed a good fit, which improved further after removing the Hunger subscale. All subscales demonstrated strong reliability (alpha and omega > 0.70). Females exhibited higher scores in Enjoyment of Food, Emotional Over-eating, Food Responsiveness, and Satiety Responsiveness than males (p < 0.05). Food approach traits (except for Hunger) were positively correlated with BMI (p < 0.05), whereas food avoidance traits (except for Food Fussiness) were negatively correlated (p < 0.05). CONCLUSION: The AEBQ is a reliable and valid psychological measurement for assessing appetitive traits in Chinese adults and conducting large-scale studies. Interventions targeting appetite traits provide new insights into weight management and obesity prevention. CI - Copyright (c) 2025 Yan, Shah, Yang, Pan and Sun. FAU - Yan, Qinyu AU - Yan Q AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China. FAU - Shah, Muhammad Waseem AU - Shah MW AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China. FAU - Yang, Jin AU - Yang J AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China. FAU - Pan, Da AU - Pan D AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China. FAU - Sun, Guiju AU - Sun G AD - Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, China. LA - eng PT - Journal Article PT - Validation Study DEP - 20251112 PL - Switzerland TA - Front Public Health JT - Frontiers in public health JID - 101616579 SB - IM MH - Humans MH - Female MH - Male MH - *Students/statistics & numerical data/psychology MH - *Body Mass Index MH - *Feeding Behavior/psychology MH - Universities MH - *Psychometrics MH - Cross-Sectional Studies MH - Surveys and Questionnaires/standards MH - China MH - Adult MH - Young Adult MH - Reproducibility of Results MH - Adolescent PMC - PMC12646881 OTO - NOTNLM OT - Chinese university students OT - adult eating behavior questionnaire OT - appetitive traits OT - body mass index OT - obesity COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2025/11/28 06:28 MHDA- 2025/11/28 06:29 PMCR- 2025/11/12 CRDT- 2025/11/28 04:47 PHST- 2025/08/23 00:00 [received] PHST- 2025/10/31 00:00 [accepted] PHST- 2025/11/28 06:29 [medline] PHST- 2025/11/28 06:28 [pubmed] PHST- 2025/11/28 04:47 [entrez] PHST- 2025/11/12 00:00 [pmc-release] AID - 10.3389/fpubh.2025.1691302 [doi] PST - epublish SO - Front Public Health. 2025 Nov 12;13:1691302. doi: 10.3389/fpubh.2025.1691302. eCollection 2025. PMID- 41312058 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20260919 IS - 0966-9760 (Print) IS - 1469-8463 (Electronic) IS - 0966-9760 (Linking) VI - 33 IP - 4 DP - 2025 TI - Building Professional Learning Communities in Head Start: A Mixed Methods Study on What it Takes from Teachers' Perspectives. PG - 668-687 LID - 10.1080/09669760.2025.2522894 [doi] AB - Professional learning communities (PLC) are a form of collaborative professional development consisting of a group of teachers that meet regularly to share ideas and problem solve teaching strategies. PLCs are widely utilized internationally in primary and secondary educational settings, but less is known about their perception and use in the early childhood environment. In this parallel mixed-methods study, we explored North Carolina Head Start preschool teachers' perceptions and experiences with PLCs, through the collection of quantitative survey data (n=168) and qualitative telephone interviews (n=11). We coded and analyzed qualitative data following a phenomenological approach and identified six qualitative themes: (1) Receiving and Providing Support; (2) Mutual Trust and Respect; (3) Structure and Organization; (4) Supervisor Involvement; (5) Learning to Teach Science and Nutrition; and (6) Barriers to PLCs. Integrating both qualitative and quantitative findings, teachers generally perceived PLCs positively but faced barriers. Teachers may lack knowledge in content areas they were interested in forming a PLC around (e.g., science, nutrition). Additional research is warranted to investigate facilitators to overcome teachers' barriers to PLCs and further examine the use and feasibility of PLCs in the Head Start environment. FAU - Dixon, Jocelyn AU - Dixon J AD - Department of Agricultural and Human Science, NC State University, NC State Extension. FAU - Resor, Jessica AU - Resor J AD - Department of Human Development and Family Science, East Carolina University. FAU - Holmes, Lanie AU - Holmes L AD - Department of Human Development and Family Science, East Carolina University. FAU - Hegde, Archana V AU - Hegde AV AD - Department of Human Development and Family Science, East Carolina University. FAU - Goodell, L Suzanne AU - Goodell LS AD - Department of Food, Bioprocessing & Nutrition Sciences, NC State University. FAU - Mendez, Lucia AU - Mendez L AD - Department of Communication Sciences and Disorders, University of North Carolina Greensboro. FAU - McMillan, Valerie AU - McMillan V AD - Department of Family and Consumer Sciences, North Carolina Agricultural and Technical State University. FAU - Stage, Virginia C AU - Stage VC AD - Department of Agricultural and Human Science, NC State University, NC State Extension. LA - eng GR - R25 GM132939/GM/NIGMS NIH HHS/United States PT - Journal Article DEP - 20250628 PL - England TA - Int J Early Years Educ JT - International journal of early years education JID - 101536714 PMC - PMC12650122 MID - NIHMS2092794 OTO - NOTNLM OT - Early Childhood Education OT - Head Start OT - Preschool OT - Professional Development OT - Professional Learning Communities COIS- Disclosure Statement: The authors report there are no competing interests to declare. EDAT- 2025/11/28 06:27 MHDA- 2025/11/28 06:28 PMCR- 2026/06/28 CRDT- 2025/11/28 04:44 PHST- 2025/11/28 06:28 [medline] PHST- 2025/11/28 06:27 [pubmed] PHST- 2025/11/28 04:44 [entrez] PHST- 2026/06/28 00:00 [pmc-release] AID - 10.1080/09669760.2025.2522894 [doi] PST - ppublish SO - Int J Early Years Educ. 2025;33(4):668-687. doi: 10.1080/09669760.2025.2522894. Epub 2025 Jun 28. PMID- 41312031 OWN - NLM STAT- PubMed-not-MEDLINE DCOM- 20251128 LR - 20251130 IS - 2477-4073 (Electronic) IS - 2528-181X (Print) IS - 2477-4073 (Linking) VI - 11 IP - 6 DP - 2025 TI - Barriers to breastfeeding among mothers in the northern border region of Saudi Arabia: A cross-sectional study. PG - 749-760 LID - 10.33546/bnj.4026 [doi] AB - BACKGROUND: Although breastfeeding is widely recognized for its essential nutritional and protective health benefits for infants, exclusive breastfeeding rates remain suboptimal in many populations globally and within Saudi Arabia. There is a paucity of region-specific data detailing the barriers to breastfeeding among mothers, particularly in the Northern Border region. Understanding these barriers is crucial for developing culturally appropriate interventions and public health policies that can enhance breastfeeding practices and maternal support systems. OBJECTIVE: This study aimed to identify and analyze the barriers affecting exclusive breastfeeding among mothers in the Northern Border region of Saudi Arabia. METHODS: A community-based cross-sectional survey was conducted among mothers aged 18 years and older residing in the Northern Border region of Saudi Arabia between February and May 2025. Data were collected using a structured, pre-validated online questionnaire in Arabic, disseminated via social media platforms to ensure broad participation. Descriptive statistics were used to summarize participant characteristics and knowledge levels, while inferential statistics were used to examine associations between demographic factors, knowledge scores, and identified barriers. RESULTS: A total of 453 mothers participated in the study (mean age: 36.9 +/- 8.1 years), of whom 91.6% reported prior breastfeeding experience. Knowledge scores ranged from 24 to 60 (mean: 46.1 +/- 6.9). Higher knowledge levels were observed among mothers aged over 40 years (p = 0.0001), those with more than four children (p = 0.02), and participants with an average standard of living (p = 0.0001). Previous breastfeeding experience was significantly associated with older age (p <0.001) and employment status (p = 0.03). Working mothers, particularly those employed on shifts or hourly wages, reported significantly more barriers to exclusive breastfeeding (p = 0.001, p = 0.03, p = 0.0006). The most frequently reported challenges included insufficient workplace support and inadequate maternity leave, affecting 69.5% of respondents. CONCLUSION: Barriers to exclusive breastfeeding in the Northern Border region are predominantly workplace-related and institutional, including limited lactation facilities, lack of designated nursing breaks, rigid work schedules, and insufficient organizational support. Addressing these challenges through the implementation of supportive workplace policies, flexible scheduling, and targeted health education initiatives could substantially improve exclusive breastfeeding rates and promote better maternal and infant health outcomes. CI - (c) The Author(s) 2025. FAU - E Esmaeel, Safya AU - E Esmaeel S AUID- ORCID: 0000-0002-9313-2656 AD - Department of Physiology, College of Medicine, Northern Border University, Arar, Saudi Arabia. FAU - Khalid Alobaidan, Rahaf AU - Khalid Alobaidan R AUID- ORCID: 0009-0001-9359-0657 AD - College of Medicine, Northern Border University, Arar, Saudi Arabia. FAU - Faez K Alenezi, Dana AU - Faez K Alenezi D AUID- ORCID: 0009-0007-8954-6649 AD - College of Medicine, Northern Border University, Arar, Saudi Arabia. FAU - Salamah F Alanazi, Farah AU - Salamah F Alanazi F AUID- ORCID: 0009-0003-5293-3240 AD - College of Medicine, Northern Border University, Arar, Saudi Arabia. FAU - Maqil T Alanazi, Rahaf AU - Maqil T Alanazi R AUID- ORCID: 0009-0004-2472-9688 AD - College of Medicine, Northern Border University, Arar, Saudi Arabia. FAU - Dhaher A Alharbi, Atheer AU - Dhaher A Alharbi A AUID- ORCID: 0009-0006-7132-1719 AD - College of Medicine, Northern Border University, Arar, Saudi Arabia. FAU - Hameed G Alanezi, Haneen AU - Hameed G Alanezi H AUID- ORCID: 0009-0004-1705-4563 AD - College of Medicine, Northern Border University, Arar, Saudi Arabia. FAU - Hussin A Alruwili, Leen AU - Hussin A Alruwili L AUID- ORCID: 0009-0006-8864-8224 AD - College of Medicine, Northern Border University, Arar, Saudi Arabia. FAU - Abu Alsel, Baraah AU - Abu Alsel B AUID- ORCID: 0000-0003-3811-0822 AD - Department of Medical Sciences and Preparatory Year, North Private College of Nursing, Arar, Saudi Arabia. FAU - Hamid, Omaima A AU - Hamid OA AUID- ORCID: 0009-0009-9120-3236 AD - Department of Obstetrics and Gynaecology, College of Medicine, Northern Border University, Arar, Saudi Arabia. FAU - Hassan Abdalla Hashim, Sawsan AU - Hassan Abdalla Hashim S AUID- ORCID: 0009-0006-3882-3653 AD - Department of Pediatrics, College of Medicine, Northern Border University, Arar, Saudi Arabia. FAU - Bayomy, Hanaa E AU - Bayomy HE AUID- ORCID: 0000-0001-7273-7931 AD - Department of Family and Community Medicine, Faculty of Medicine, Northern Border University, Arar, Saudi Arabia. AD - Department of Community, Environmental, and Occupational Medicine, Faculty of Medicine, Benha University, Benha, Egypt. FAU - Fawzy, Manal S AU - Fawzy MS AUID- ORCID: 0000-0003-1252-8403 AD - Center for Health Research, Northern Border University, Arar, Saudi Arabia. LA - eng PT - Journal Article DEP - 20251126 PL - Indonesia TA - Belitung Nurs J JT - Belitung nursing journal JID - 101685037 PMC - PMC12648221 OTO - NOTNLM OT - Saudi Arabia OT - barriers OT - bottle feeding OT - breastfeeding OT - infant OT - mothers COIS- No conflict of interest to declare in this study. EDAT- 2025/11/28 06:28 MHDA- 2025/11/28 06:29 PMCR- 2025/11/26 CRDT- 2025/11/28 04:43 PHST- 2025/05/12 00:00 [received] PHST- 2025/06/22 00:00 [revised] PHST- 2025/10/06 00:00 [accepted] PHST- 2025/11/28 06:29 [medline] PHST- 2025/11/28 06:28 [pubmed] PHST- 2025/11/28 04:43 [entrez] PHST- 2025/11/26 00:00 [pmc-release] AID - BNJ-11-6-749 [pii] AID - 10.33546/bnj.4026 [doi] PST - epublish SO - Belitung Nurs J. 2025 Nov 26;11(6):749-760. doi: 10.33546/bnj.4026. eCollection 2025. PMID- 41310824 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20260627 IS - 1824-7288 (Electronic) IS - 1720-8424 (Linking) VI - 51 IP - 1 DP - 2025 Nov 27 TI - Value of the neutrophil percentage-to-albumin ratio in predicting intravenous Immunoglobulin resistance in Kawasaki disease: a retrospective cohort study. PG - 330 LID - 10.1186/s13052-025-02158-6 [doi] LID - 330 AB - BACKGROUND: Intravenous immunoglobulin (IVIG) resistance in Kawasaki disease (KD) is associated with coronary artery lesions (CALs). Available studies suggest that inflammation and nutritional status play a key role in IVIG resistance. Given this, the neutrophil percentage to albumin ratio (NPAR), a new combined indicator of inflammation and nutritional status, may be an important predictor of IVIG resistance. METHODS: This was a retrospective cohort study involving 591 children diagnosed with KD. Participants were categorized based on their NPAR levels, and their clinical data were analyzed to assess the relationship between NPAR and IVIG resistance. Multivariable logistic regression model was conducted to evaluate the association between inflammatory biomarkers and IVIG resistance. A restricted cubic spline (RCS) model was employed to investigate the dose-response relationship between NPAR, other inflammatory biomarkers, and the risk of IVIG resistance. Furthermore, subgroup analyses were performed to assess the effects of age, sex, and other relevant factors on the association between NPAR and IVIG resistance. The receiver operating characteristic curve (ROC) was utilized to estimate the predictive power of NPAR and other inflammatory biomarkers. RESULTS: Among 591 participants with KD, 72 (12.2%) were IVIG resistance, and these patients showed a higher incidence of CALs (26.4% vs. 11.6%). Higher NPAR levels were significantly associated with an increased proportion of IVIG resistance. Specifically, the proportion of IVIG resistance was 2.5% in the lowest NPAR tertile, compared to 25.4% in the highest tertile (p < 0.001). The multivariable logistic regression model confirmed that NPAR was significantly associated with IVIG resistance. Each unit increase in NPAR was linked to 14.53 times increase in the odds of IVIG resistance (OR: 15.53, 95% CI: 7.83-30.84, p < 0.001). After adjusting for confounders such as age, gender, and laboratory parameters, the association remained strong (OR: 21.80, 95% CI: 8.84-53.74, p < 0.001). Additionally, the study demonstrated a dose-response relationship between NPAR levels and IVIG resistance, with higher NPAR values corresponding to greater risk. Subgroup analyses confirmed the stability of these findings. Furthermore, the area under the curve (AUC) for NPAR predicting IVIG resistance was 0.794, outperforming other inflammatory biomarkers. CONCLUSION: This study demonstrated that NPAR, as a comprehensive indicator of inflammation and nutritional status, was significantly associated with IVIG resistance and can serve as a reliable predictor. Although the clinical application value of NPAR requires further validation, it shows promise as a novel biomarker for early identification of high-risk individuals and improving clinical management strategies. CLINICAL TRAIL NUMBER: Not applicable. FAU - Du, Qingxia AU - Du Q AUID- ORCID: 0009-0003-6377-2104 AD - Department of Cardiovascular Medicine, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China. AD - Department of Cardiovascular Medicine, Jinan Children's Hospital, Jinan, Shandong, China. FAU - Zhang, Xin AU - Zhang X AD - Department of Cardiovascular Medicine, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China. AD - Department of Cardiovascular Medicine, Jinan Children's Hospital, Jinan, Shandong, China. FAU - Sun, Honglin AU - Sun H AD - Department of Cardiovascular Medicine, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China. AD - Department of Cardiovascular Medicine, Jinan Children's Hospital, Jinan, Shandong, China. FAU - Bi, Zhenze AU - Bi Z AD - Department of Cardiovascular Medicine, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China. AD - Department of Cardiovascular Medicine, Jinan Children's Hospital, Jinan, Shandong, China. FAU - Li, Xinxiang AU - Li X AD - Department of Cardiovascular Medicine, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China. AD - Department of Cardiovascular Medicine, Jinan Children's Hospital, Jinan, Shandong, China. FAU - Wei, Xiaoling AU - Wei X AD - Department of Health Data Application and Management, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China. AD - Department of Health Data Application and Management, Jinan Children's Hospital, Jinan, Shandong, China. FAU - Li, Lei AU - Li L AUID- ORCID: 0009-0005-5168-5657 AD - Department of Cardiovascular Medicine, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China. talilei1981@163.com. AD - Department of Cardiovascular Medicine, Jinan Children's Hospital, Jinan, Shandong, China. talilei1981@163.com. FAU - Zhou, Weiran AU - Zhou W AD - Department of Nephrology, Rheumatism and Immunology, Children's Hospital Affiliated to Shandong University, Jinan, Shandong, China. weiranxue2014@163.com. AD - Department of Nephrology, Rheumatism and Immunology, Jinan Children's Hospital, Jinan, Shandong, China. weiranxue2014@163.com. LA - eng GR - 2022-2-150/Science and Technology Development Program of Jinan Municipal Health Commission/ GR - 2023-2-144/Science and Technology Development Program of Jinan Municipal Health Commission/ PT - Journal Article DEP - 20251127 PL - England TA - Ital J Pediatr JT - Italian journal of pediatrics JID - 101510759 RN - 0 (Immunoglobulins, Intravenous) RN - 0 (Biomarkers) RN - 0 (Serum Albumin) SB - IM MH - Humans MH - *Mucocutaneous Lymph Node Syndrome/drug therapy/blood MH - Retrospective Studies MH - *Immunoglobulins, Intravenous/therapeutic use MH - Female MH - Male MH - *Neutrophils MH - *Drug Resistance MH - Child, Preschool MH - Biomarkers/blood MH - ROC Curve MH - Infant MH - Predictive Value of Tests MH - Logistic Models MH - *Serum Albumin/analysis/metabolism MH - Cohort Studies MH - Child MH - Leukocyte Count PMC - PMC12751695 OTO - NOTNLM OT - Coronary artery lesions (CALs) OT - Intravenous immunoglobulin resistance (IVIG) OT - Kawasaki disease (KD) OT - Neutrophil percentage-to-albumin ratio (NPAR) COIS- Declarations. Ethics approval and consent to participate: The study was approved by the Research Ethics Committee of Jinan Children's Hospital (Children's Hospital Affiliated to Shandong University), and the requirement for informed consent was waived owing to the observation nature of this study. This study was performed in compliance with the Declaration of Helsinki andother relevant regulations. Consent for publication: Not applicable. Competing interests: The authors declare that they have no competing interests. EDAT- 2025/11/28 06:28 MHDA- 2026/06/27 06:46 PMCR- 2025/11/27 CRDT- 2025/11/28 00:16 PHST- 2025/08/15 00:00 [received] PHST- 2025/11/04 00:00 [accepted] PHST- 2026/06/27 06:46 [medline] PHST- 2025/11/28 06:28 [pubmed] PHST- 2025/11/28 00:16 [entrez] PHST- 2025/11/27 00:00 [pmc-release] AID - 10.1186/s13052-025-02158-6 [pii] AID - 2158 [pii] AID - 10.1186/s13052-025-02158-6 [doi] PST - epublish SO - Ital J Pediatr. 2025 Nov 27;51(1):330. doi: 10.1186/s13052-025-02158-6. PMID- 41310816 OWN - NLM STAT- MEDLINE DCOM- 20251231 LR - 20260919 IS - 1757-2215 (Electronic) IS - 1757-2215 (Linking) VI - 18 IP - 1 DP - 2025 Nov 27 TI - A prospective cohort study on progestin-primed ovarian stimulation vs. GnRH antagonist in IVF-ICSI cycles: effects on clinical pregnancy and neonatal outcomes. PG - 313 LID - 10.1186/s13048-025-01885-y [doi] LID - 313 AB - BACKGROUND: In assisted reproductive technology, preventing premature ovulation is crucial for achieving successful pregnancy outcomes. The traditional GnRH antagonist protocol is commonly used to suppress the luteinizing hormone (LH) surge, while the progesterone-primed ovarian stimulation (PPOS) protocol has gained attention due to its simplicity, lower cost, and fewer side effects. This study compared the PPOS and GnRH antagonist protocols in frozen embryo transfer (FET) cycles, focusing on evaluating the safety of the PPOS protocol and its impact on neonatal birth outcomes. METHODS: This prospective cohort study was conducted at the Assisted Reproductive Medicine Department of the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, from January 2020 to December 2023. The study included infertile patients who underwent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) treatment, followed by frozen embryo transfer. To balance baseline characteristics and ensure a fair comparison, a combination of propensity score matching (PSM) and inverse probability of treatment weighting (IPTW) was employed. PSM and IPTW were used to match patients based on baseline characteristics, including age, body mass index (BMI), infertility duration, hormone levels (FSH, LH, E2), pregnancy history, and other factors. RESULTS: The study compared the outcomes of IVF/ICSI using PPOS and GnRH antagonist protocols. After propensity score matching, 1,950 patients were included in each group. No significant differences were observed between the PPOS and GnRH antagonist groups in clinical pregnancy rate (46.26% vs. 46.21%, P = 0.979), live birth rate (36.26% vs. 35.49%, P = 0.550), miscarriage rate (10.05% vs. 10.72%, P = 0.375), or ectopic pregnancy rate (0.82% vs. 0.82%, P = 0.880). There were no significant differences were found between the two protocols in neonatal outcomes, including sex distribution and incidence of congenital anomalies. Further analysis of singleton live births showed no significant differences in the risk of low birth weight between groups (4.86% vs. 3.16%, adjusted OR = 1.62, 95% CI: 0.97-2.71, P = 0.063) or congenital anomalies (2.35% vs. 1.58%, adjusted OR = 0.67, 95% CI: 0.32-1.39, P = 0.278). In IVF/ICSI treatment, the PPOS protocol showed similar live birth rates and neonatal health outcomes compared to the GnRH antagonist protocol. INNOVATION AND CONTRIBUTION: This prospective cohort study observed patients undergoing IVF/ICSI treatment with either the PPOS or GnRH antagonist protocols, ensuring a fair comparison. PSM and IPTW were used to balance baseline characteristics and adjust for remaining differences, thereby improving the reliability of the results. A key strength lies in the large matched sample, which enhances statistical power. Additionally, unlike previous studies, this research included neonatal outcomes, offering a more comprehensive evaluation of both pregnancy success and infant health. The combination of advanced statistical methods and a focus on long-term outcomes renders this study a significant contribution to the field of infertility treatment. CI - (c) 2025. The Author(s). FAU - Yang, Chuning AU - Yang C AD - Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China. AD - Sejong University, Seoul, Republic of Korea. FAU - Chen, Qiuju AU - Chen Q AD - Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China. FAU - Shen, Xi AU - Shen X AD - Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China. FAU - Guo, Haiyan AU - Guo H AD - Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China. FAU - Lin, Jiaying AU - Lin J AD - Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China. FAU - Lu, Xuefeng AU - Lu X AD - Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China. FAU - Wen, Xiaowei AU - Wen X AD - Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China. 506161005@qq.com. AD - Xi'an Jiaotong-Liverpool University, Suzhou, China. 506161005@qq.com. FAU - Zhu, Qianqian AU - Zhu Q AD - Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China. qianqianzhu1988@126.com. FAU - Chai, Weiran AU - Chai W AD - Shanghai Jiao Tong University School of Medicine, Shanghai Ninth People's Hospital, Shanghai, China. chaiwrcn@163.com. LA - eng GR - JYLJ202002/Clinical Research Promotion Program/ PT - Journal Article DEP - 20251127 PL - England TA - J Ovarian Res JT - Journal of ovarian research JID - 101474849 RN - 33515-09-2 (Gonadotropin-Releasing Hormone) RN - 0 (Progestins) RN - 0 (Hormone Antagonists) SB - IM EIN - J Ovarian Res. 2026 Feb 18;19(1):65. doi: 10.1186/s13048-026-02020-1. PMID: 41709325 MH - Humans MH - Female MH - Pregnancy MH - *Ovulation Induction/methods MH - *Fertilization in Vitro/methods MH - Adult MH - *Gonadotropin-Releasing Hormone/antagonists & inhibitors MH - Prospective Studies MH - *Sperm Injections, Intracytoplasmic/methods MH - Pregnancy Outcome MH - *Progestins/pharmacology/therapeutic use MH - Pregnancy Rate MH - Infant, Newborn MH - *Hormone Antagonists/therapeutic use MH - Embryo Transfer PMC - PMC12750736 OTO - NOTNLM OT - Assisted reproductive technology OT - FET OT - GnRH antagonist OT - ICSI OT - IVF OT - Live birth rate OT - PPOS COIS- Declarations. Ethics approval and consent to participate: All participants provided written informed consent prior to enrollment. The study protocol was approved by the Ethics Committee of the Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine (approval number: SH9H-2020-T351-2), and all procedures were conducted in accordance with the Declaration of Helsinki. Consent for publication: This manuscript is original, has not been published or submitted elsewhere, and is not under consideration by any other journal. All authors approved the final version and consent to its submission. All participants provided written informed consent for the publication of this manuscript. Competing interests: The authors declare no competing interests. Clinical trial number: This study is not a registered clinical trial. Therefore, clinical trial number: not applicable. EDAT- 2025/11/28 06:27 MHDA- 2025/12/31 07:37 PMCR- 2025/11/27 CRDT- 2025/11/28 00:16 PHST- 2025/04/10 00:00 [received] PHST- 2025/10/28 00:00 [accepted] PHST- 2025/12/31 07:37 [medline] PHST- 2025/11/28 06:27 [pubmed] PHST- 2025/11/28 00:16 [entrez] PHST- 2025/11/27 00:00 [pmc-release] AID - 10.1186/s13048-025-01885-y [pii] AID - 1885 [pii] AID - 10.1186/s13048-025-01885-y [doi] PST - epublish SO - J Ovarian Res. 2025 Nov 27;18(1):313. doi: 10.1186/s13048-025-01885-y. PMID- 41310718 OWN - NLM STAT- MEDLINE DCOM- 20251128 LR - 20260908 IS - 1475-2840 (Electronic) IS - 1475-2840 (Linking) VI - 24 IP - 1 DP - 2025 Nov 27 TI - Plasma inflammatory proteome profiles identify MASLD among children with overweight or obesity. PG - 450 LID - 10.1186/s12933-025-03011-0 [doi] LID - 450 AB - BACKGROUND & AIMS: Pediatric metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly prevalent among children with overweight or obesity, yet its early diagnosis remains a major clinical challenge. This study aimed to identify circulating inflammatory proteins associated with MASLD and to develop a proteomic risk score (ProScore) to improve diagnostic accuracy. METHODS: In this cross-sectional study of 161 children (median age 8.5 years) with overweight or obesity, MASLD was assessed by vibration-controlled transient elastography, with 42 cases identified. Plasma concentrations of 92 inflammation-related proteins were quantified using a high-throughput proximity extension assay. The ProScore was compared with eleven conventional anthropometric/metabolic indices (WHtR, METS-IR, SPISE, PNFI, VAI, LAP, TyG, TyG-ALT, TyG-WC, TyG-WHtR, and TyG-BMI) and a genetic risk score (GRS). Six machine learning algorithms were employed and diagnostic performance was assessed using area under the curve (AUC) with fivefold cross-validation. RESULTS: Fifteen proteins were significantly associated with MASLD. A six-protein panel (FGF-21, CDCP1, CD244, OPG, Flt3L, MCP-1) achieved the highest diagnostic accuracy (AUC = 0.84), exceeding that of all conventional indices (AUC = 0.65-0.78; all P < 0.05). ProScore performance remained robust in school-based validation (AUC = 0.83), with no substantial improvement when combined with conventional indices. Diagnostic accuracy was higher in children with lower GRS (AUC = 0.92) than in those with higher GRS (AUC = 0.80; P = 0.003). CONCLUSIONS: A proteomic signature of systemic inflammation provides accurate, non-invasive identification of MASLD in at-risk children, outperforming conventional metabolic and genetic tools, and may have utility in clinical and public health settings. CI - (c) 2025. The Author(s). FAU - Wang, Youxin AU - Wang Y AUID- ORCID: 0009-0002-3340-8961 AD - Department of Maternal and Child Health, School of Public Health, Peking University/National Health Commission Key Laboratory of Reproductive Health, Xueyuan Rd 38, Haidian District, Beijing, 100191, China. FAU - Huang, Daniel Q AU - Huang DQ AD - Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. AD - Division of Gastroenterology and Hepatology, Department of Medicine, National University Health System, Singapore, Singapore. FAU - Zhang, Pingping AU - Zhang P AD - Ningbo Centre for Healthy Lifestyle Research, Chronic Disease Management Office, The First Affiliated Hospital of Ningbo University, No. 59 Liuting Street, Haishu District, Ningbo, 315000, Zhejiang Province, China. FAU - Wang, Mingyue AU - Wang M AD - Department of Maternal and Child Health, School of Public Health, Peking University/National Health Commission Key Laboratory of Reproductive Health, Xueyuan Rd 38, Haidian District, Beijing, 100191, China. FAU - Wu, Yuying AU - Wu Y AD - Department of Maternal and Child Health, School of Public Health, Peking University/National Health Commission Key Laboratory of Reproductive Health, Xueyuan Rd 38, Haidian District, Beijing, 100191, China. FAU - Nur, Enkar AU - Nur E AD - Department of Maternal and Child Health, School of Public Health, Peking University/National Health Commission Key Laboratory of Reproductive Health, Xueyuan Rd 38, Haidian District, Beijing, 100191, China. FAU - Li, Li AU - Li L AD - Department of Endocrinology and Metabolism, The First Affiliated Hospital of Ningbo University, Ningbo, Zhejiang Province, China. lilyningbo@163.com. FAU - Wang, Hui AU - Wang H AUID- ORCID: 0000-0002-7639-5702 AD - Department of Maternal and Child Health, School of Public Health, Peking University/National Health Commission Key Laboratory of Reproductive Health, Xueyuan Rd 38, Haidian District, Beijing, 100191, China. huiwang@bjmu.edu.cn. LA - eng GR - 202406010169/Program of China Scholarship Council in National University of Singapore/ GR - 2025KY1315/Medical Health Science and Technology Project of Zhejiang Province/ GR - WKJ-ZJ-2216/Major Science and Technology Projects for Health of Zhejiang Province/ GR - LTGY24H260007/Zhejiang Provincial Natural Science Foundation of China/ GR - 2022-B126/Cyrus Tang Foundation/ PT - Journal Article DEP - 20251127 PL - England TA - Cardiovasc Diabetol JT - Cardiovascular diabetology JID - 101147637 RN - 0 (Biomarkers) RN - 0 (Proteome) RN - 0 (Inflammation Mediators) SB - IM MH - Humans MH - Male MH - Female MH - *Pediatric Obesity/blood/diagnosis/epidemiology MH - Cross-Sectional Studies MH - Child MH - Biomarkers/blood MH - *Proteomics/methods MH - *Proteome MH - *Inflammation Mediators/blood MH - Risk Factors MH - Predictive Value of Tests MH - Adolescent MH - Risk Assessment MH - Age Factors MH - Reproducibility of Results MH - *Fatty Liver/blood/diagnosis/epidemiology MH - Elasticity Imaging Techniques MH - Child, Preschool MH - Early Diagnosis PMC - PMC12659286 OTO - NOTNLM OT - Genetic risk score OT - Inflammatory proteome OT - MASLD OT - Non-invasive indices OT - Pediatrics COIS- Declarations. Conflict of interest: Daniel Q. Huang has served as an advisory board member for Gilead and Roche. All other authors do not have any conflicts of interest. EDAT- 2025/11/28 06:27 MHDA- 2025/11/28 06:28 PMCR- 2025/11/27 CRDT- 2025/11/28 00:12 PHST- 2025/08/16 00:00 [received] PHST- 2025/11/04 00:00 [accepted] PHST- 2025/11/28 06:28 [medline] PHST- 2025/11/28 06:27 [pubmed] PHST- 2025/11/28 00:12 [entrez] PHST- 2025/11/27 00:00 [pmc-release] AID - 10.1186/s12933-025-03011-0 [pii] AID - 3011 [pii] AID - 10.1186/s12933-025-03011-0 [doi] PST - epublish SO - Cardiovasc Diabetol. 2025 Nov 27;24(1):450. doi: 10.1186/s12933-025-03011-0. PMID- 41310564 OWN - NLM STAT- MEDLINE DCOM- 20260626 LR - 20260626 IS - 1472-6831 (Electronic) IS - 1472-6831 (Linking) VI - 25 IP - 1 DP - 2025 Nov 28 TI - Artificial intelligence versus human expertise: reliability of ChatGPT and the London atlas for dental age estimation using panoramic radiographs. PG - 2002 LID - 10.1186/s12903-025-07360-w [doi] LID - 2002 AB - BACKGROUND: This study evaluated the performance of ChatGPT, a multimodal large language model (LLM), in estimating dental age from panoramic radiographs (PRs) and compared its accuracy and reproducibility with those of the London Atlas (LA) method. METHODS: PRs of 620 healthy children aged 6 through 13 years were retrospectively analyzed. An experienced dentomaxillofacial radiologist estimated dental age using the LA, and the ChatGPT-4o model analyzed the same anonymized images to generate automated age predictions. Both methods were repeated after two weeks to assess intra-observer reliability. Predictive accuracy and agreement with chronological age (CA) were evaluated using mean absolute error (MAE), root mean squared error (RMSE), intraclass correlation coefficients (ICC), and Bland-Altman analyses. Statistical significance was set at p < .05. RESULTS: ChatGPT's predictions differed significantly from chronological age (CA), tending to overestimate age in younger children and underestimate age in older children. Compared with the LA, ChatGPT exhibited higher MAE and RMSE values, indicating lower predictive accuracy and greater variability. Error magnitudes were greatest in the 6-, 12-, and 13-year-old groups and lowest in the 8-year-old group, whereas the LA showed lower and more stable errors across ages. The LA demonstrated fewer discrepancies and excellent reproducibility (ICC = 0.960) as compared with the moderate agreement of ChatGPT (ICC = 0.703). Overall, the LA provided estimates closer to CA, whereas ChatGPT exhibited greater variability. CONCLUSIONS: ChatGPT shows promise for complex decision-making tasks such as dental age estimation; however, its current accuracy, reproducibility, and output stability remain inferior to established methods such as the LA. The inconsistent predictions observed across repeated evaluations highlight a critical limitation regarding its reliability for clinical and forensic applications. Therefore, ChatGPT-based estimations should be interpreted with caution until future versions achieve more consistent and reproducible performance through population-specific training, model optimization, and multicenter validation. FAU - Peker, Ramazan Berkay AU - Peker RB AUID- ORCID: 0000-0003-3162-6236 AD - Department of Dentomaxillofacial Radiology, Trakya University Faculty of Dentistry, Balkan Campus, Edirne, 22030, Turkey. rberkaypeker@trakya.edu.tr. LA - eng PT - Comparative Study PT - Journal Article DEP - 20251128 PL - England TA - BMC Oral Health JT - BMC oral health JID - 101088684 SB - IM MH - Humans MH - Child MH - Adolescent MH - *Age Determination by Teeth/methods MH - Reproducibility of Results MH - *Radiography, Panoramic MH - Retrospective Studies MH - Female MH - Large Language Models MH - Male MH - Generative Artificial Intelligence MH - Observer Variation MH - *Artificial Intelligence PMC - PMC12751685 OTO - NOTNLM OT - Artificial intelligence OT - ChatGPT OT - Dental age estimation OT - London atlas OT - Panoramic radiography OT - Reliability COIS- Declarations. Ethics approval and consent to participate: The Non‑Interventional Scientific Research Ethics Committee of Trakya University Faculty of Medicine, Turkey, approved this retrospective observational study (No. TUTF-GOBEAK 2025/376). All panoramic radiographs were anonymized prior to analysis, and no identifiable personal information was used. All procedures performed in this study involving human data were conducted in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards. As this study involved only retrospective analysis of existing, anonymized clinical data, the ethics committee waived the requirement for informed consent. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/28 06:27 MHDA- 2026/06/27 00:50 PMCR- 2025/11/28 CRDT- 2025/11/28 00:07 PHST- 2025/09/14 00:00 [received] PHST- 2025/11/14 00:00 [accepted] PHST- 2026/06/27 00:50 [medline] PHST- 2025/11/28 06:27 [pubmed] PHST- 2025/11/28 00:07 [entrez] PHST- 2025/11/28 00:00 [pmc-release] AID - 10.1186/s12903-025-07360-w [pii] AID - 7360 [pii] AID - 10.1186/s12903-025-07360-w [doi] PST - epublish SO - BMC Oral Health. 2025 Nov 28;25(1):2002. doi: 10.1186/s12903-025-07360-w. PMID- 41310531 OWN - NLM STAT- MEDLINE DCOM- 20260104 LR - 20260607 IS - 1471-2458 (Electronic) IS - 1471-2458 (Linking) VI - 26 IP - 1 DP - 2025 Nov 27 TI - Feasibility and acceptability of an implementation strategy to enhance use of classroom-based physical activity approaches in elementary schools: a mixed methods study. PG - 36 LID - 10.1186/s12889-025-25333-0 [doi] LID - 36 AB - BACKGROUND: Classroom-based approaches are an evidence-based way to improve children's physical activity; however, they are inconsistently implemented in schools. We developed MAGIC (Movement for Academic Growth In Classrooms), a multifaceted implementation strategy that consists of leadership training, teacher training, and a monthly newsletter to improve use of classroom-based physical activity approaches. The purpose of this study is to examine the feasibility and acceptability of MAGIC among elementary school teachers and leaders. METHODS: We used an embedded, convergent mixed methods design. We provided the MAGIC implementation strategy to a partner elementary school. We then administered surveys to teachers to quantitatively examine feasibility and acceptability. The surveys included questions about training attendance, receipt of newsletters, and acceptability based on a theoretical framework of acceptability. We used descriptive statistics to understand feasibility and acceptability trends. We also conducted semi-structured group and individual interviews with teachers and school leaders to understand perspectives about MAGIC components. We used rapid assessment procedures to analyze qualitative data, and multiple integration strategies, including joint displays, to compare quantitative and qualitative findings. RESULTS: A total of 35 teachers (kindergarten-5(th) grade) completed study surveys and 27 teachers and school leaders participated in interviews. As an indicator of feasibility, all leaders attended leadership training sessions 1 (n = 13/13), 2 (n = 13/13), and 4 (n = 7/7); and 57% attended session 3 (n = 7/13); 93% (n = 28/30) of teachers attended training session 1, 90% (n = 27/20) attended session 2, and 87.5% (n = 21/24) attended session 3; and 67-75% of teachers received respective newsletters. The trainings and newsletters had high acceptability levels as indicated by survey results and interview data. Trainings included flexible scheduling integrated into existing meetings, which participants reported helped improve feasibility. Participants also highlighted the importance of incorporating classroom-based approaches into trainings and the simplicity of the newsletter, which contributed to their acceptability. CONCLUSIONS: This study provides evidence supporting the feasibility and acceptability of the MAGIC implementation strategy among elementary school teachers and leaders. Future research should test MAGIC among more elementary schools to examine its impact on teacher implementation outcomes and students' physical activity levels. TRIAL REGISTRATION: ClinicalTrials.gov, NCT05048433, registered 9/8/2021, https://clinicaltrials.gov/ct2/show/NCT05048433. CI - (c) 2025. The Author(s). FAU - Walker, Timothy J AU - Walker TJ AD - Center for Health Promotion and Prevention Research, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA. Timothy.J.Walker@uth.tmc.edu. AD - UTHealth Houston Institute for Implementation Science, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA. Timothy.J.Walker@uth.tmc.edu. FAU - Craig, Derek W AU - Craig DW AD - Center for Health Promotion and Prevention Research, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA. AD - UTHealth Houston Institute for Implementation Science, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA. FAU - Pfledderer, Christopher D AU - Pfledderer CD AD - Department of Health Promotion and Behavioral Sciences, University of Texas Health Science Center at Houston School of Public Health Austin Location, Austin, TX, USA. FAU - Lee, Matthew AU - Lee M AD - Center for Health Promotion and Prevention Research, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA. FAU - Onadeko, Kempson AU - Onadeko K AD - Center for Health Promotion and Prevention Research, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA. FAU - Saving, Emma E AU - Saving EE AD - Center for Health Promotion and Prevention Research, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA. FAU - Bartholomew, John B AU - Bartholomew JB AD - Department of Kinesiology, Penn State University, University Park, PA, USA. FAU - Fernandez, Maria E AU - Fernandez ME AD - Center for Health Promotion and Prevention Research, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA. AD - UTHealth Houston Institute for Implementation Science, The University of Texas Health Science Center at Houston School of Public Health, Houston, TX, USA. LA - eng SI - ClinicalTrials.gov/NCT05048433 GR - 1K01HL151817-01A1/HL/NHLBI NIH HHS/United States GR - 1K01HL151817-01A1/HL/NHLBI NIH HHS/United States PT - Journal Article PT - Randomized Controlled Trial DEP - 20251127 PL - England TA - BMC Public Health JT - BMC public health JID - 100968562 SB - IM MH - Adult MH - Child MH - Female MH - Humans MH - Male MH - *Exercise MH - Feasibility Studies MH - *Health Promotion/methods MH - Leadership MH - *School Health Services/organization & administration MH - School Teachers/psychology MH - *Schools MH - Surveys and Questionnaires MH - Teacher Training PMC - PMC12763913 OTO - NOTNLM OT - Acceptability OT - Classroom-based physical activity OT - Feasibility OT - Implementation strategy OT - Leadership training OT - Mixed methods OT - Teacher training COIS- Declarations. Ethics approval and consent to participate: Study procedures were approved by The University of Texas Health Science Center at Houston Institutional Review Board (HSC-SPH-20-0861). All participants provided written informed consent before participating in the study, which included consent to publish anonymous quotes from individual participants. This study was performed in accordance with the Declaration of Helsinki and its later amendments. Consent for publication: Not Applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/28 06:27 MHDA- 2026/01/04 11:32 PMCR- 2025/11/27 CRDT- 2025/11/28 00:06 PHST- 2025/06/09 00:00 [received] PHST- 2025/10/15 00:00 [accepted] PHST- 2026/01/04 11:32 [medline] PHST- 2025/11/28 06:27 [pubmed] PHST- 2025/11/28 00:06 [entrez] PHST- 2025/11/27 00:00 [pmc-release] AID - 10.1186/s12889-025-25333-0 [pii] AID - 25333 [pii] AID - 10.1186/s12889-025-25333-0 [doi] PST - epublish SO - BMC Public Health. 2025 Nov 27;26(1):36. doi: 10.1186/s12889-025-25333-0. PMID- 41310497 OWN - NLM STAT- MEDLINE DCOM- 20251129 LR - 20251219 IS - 1471-2415 (Electronic) IS - 1471-2415 (Linking) VI - 25 IP - 1 DP - 2025 Nov 27 TI - Prevalence of retinopathy of prematurity in African preterm infants and evaluation of the accuracy of the WINROP predictive algorithm: an observational clinical study. PG - 673 LID - 10.1186/s12886-025-04527-5 [doi] LID - 673 AB - AIM: To estimate the prevalence of retinopathy of prematurity (ROP) and investigate the prediction and validity of WINROP (Weight, Insulin-Like Growth Factor-1, Neonatal Retinopathy of Prematurity), an online monitoring algorithm in preterm infants at an African low/medium income country (LMIC) based neonatal intensive care unit (NICU). METHODS: Data from the ROP screening proforma for preterm infants between January 2020 and December 31, 2022, with gestational age (GA) from 24 to 32 weeks were entered into the WINROP algorithm system which signals an ROP risk alarm based on weekly weight gain and was compared with ophthalmology examination findings. Sensitivity, specificity, negative and positive predictive values were calculated, and statistical analysis was performed using EPI INFO (version 7.2.2.6). RESULTS: There were 168 preterm infants that met WINROP criteria. The median birth weight was 1380 g (IQR: 1141-1570 g), ranging from 600 g to 2100 g, while the median gestational age at birth was 31 weeks (IQR: 29.0-32.0 weeks), with a range of 24 to 32 weeks The overall prevalence of any ROP was 38.1% (64/168), type 1 ROP and type 2 ROP were 7.1% (12/168) and 8.9% (15/168) respectively. WINROP alarmed in 73 infants born at a gestational age (29.0 weeks, IQR: 28.0-31) and birth weight (1100 g, IQR: 912.5-1200 g). The specificity of WINROP for any ROP was 80.8% (84/104); the sensitivities for type 1 ROP and type 2 ROP were 91.7% (11/12) and 86.7% (13/15) respectively. The negative and positive predictive values were 88.4% (84/95) and 72.6% (53/73) respectively. CONCLUSION: Overall, the WINROP algorithm identified 91.7% of preterm infants who had been diagnosed and treated for type 1 ROP. Though it led to a high number of false alarms, especially in the most vulnerable infants. The algorithm's utility is likely greatest for the larger, more mature preterm infants. This confirms its usefulness to significantly reduce the number of preterm infants who need to go through stressful eye examinations in an African NICU setting where inadequate number of specialists is a major challenge. CI - (c) 2025. The Author(s). FAU - Amouzou, Dadjo AU - Amouzou D AD - Department of Ophthalmology, University of Ilorin Teaching Hospital, Kwara State, Nigeria. AD - Department of Ophthalmology, University of Lome Teaching Hospital, Lome, Togo. FAU - Ademola-Popoola, Dupe S AU - Ademola-Popoola DS AD - Department of Ophthalmology, University of Ilorin and University of Ilorin Teaching Hospital, Kwara State, Nigeria. dupsyp@yahoo.com. FAU - Obajolowo, Tokunbo S AU - Obajolowo TS AD - Department of Ophthalmology, University of Ilorin and University of Ilorin Teaching Hospital, Kwara State, Nigeria. FAU - Adesiyun, Omotayo O AU - Adesiyun OO AD - Department of Pediatrics, Neonatology Unit, University of Ilorin, University of Ilorin Teaching Hospital, Kwara State, Nigeria. FAU - Olokoba, Lateefat B AU - Olokoba LB AD - Department of Ophthalmology, University of Ilorin and University of Ilorin Teaching Hospital, Kwara State, Nigeria. FAU - Olatunji, Victoria A AU - Olatunji VA AD - Department of Ophthalmology, University of Ilorin and University of Ilorin Teaching Hospital, Kwara State, Nigeria. LA - eng PT - Journal Article PT - Observational Study DEP - 20251127 PL - England TA - BMC Ophthalmol JT - BMC ophthalmology JID - 100967802 SB - IM MH - Humans MH - *Retinopathy of Prematurity/epidemiology/diagnosis MH - Infant, Newborn MH - *Algorithms MH - Infant, Premature MH - Female MH - Prevalence MH - Male MH - Gestational Age MH - *Neonatal Screening/methods MH - Birth Weight MH - Predictive Value of Tests MH - Intensive Care Units, Neonatal MH - Prediction Algorithms PMC - PMC12661728 OTO - NOTNLM OT - Africa OT - Gestational age OT - Retinopathy of prematurity OT - WINROP algorithm COIS- Declarations. Ethics approval and consent to participate: The research conducted in this study received ethical approval from the University of Ilorin Teaching Hospital (UITH) Health Research Ethics Committee, with the assigned approval number ERC PIN/2023/05/1124 and adhered to the principles outlined in the Declaration of Helsinki. Informed consent for ROP screening was obtained from the parents/ legal guardians of the babies included in this study at the time of screening. Consent for publication: Not applicable. Competing interests: The authors declare no competing interests. EDAT- 2025/11/28 06:28 MHDA- 2025/11/29 06:29 PMCR- 2025/11/27 CRDT- 2025/11/28 00:05 PHST- 2025/08/17 00:00 [received] PHST- 2025/11/14 00:00 [accepted] PHST- 2025/11/29 06:29 [medline] PHST- 2025/11/28 06:28 [pubmed] PHST- 2025/11/28 00:05 [entrez] PHST- 2025/11/27 00:00 [pmc-release] AID - 10.1186/s12886-025-04527-5 [pii] AID - 4527 [pii] AID - 10.1186/s12886-025-04527-5 [doi] PST - epublish SO - BMC Ophthalmol. 2025 Nov 27;25(1):673. doi: 10.1186/s12886-025-04527-5. PMID- 41310411 OWN - NLM STAT- MEDLINE DCOM- 20261024 LR - 20261024 IS - 2473-4446 (Electronic) IS - 2473-3938 (Linking) VI - 10 IP - 4 DP - 2026 Nov TI - Agreement between perceived and objective sleep duration in highly trained young male soccer players. PG - 459-467 LID - 10.1080/24733938.2025.2593866 [doi] AB - This study aimed to assess the agreement between daily self-reported and actigraphy-derived sleep duration in high-level male youth soccer players over a 35-day period. Secondary analyses examined the agreement between daily self-reported sleep duration and objective time in bed (TIB), as well as the agreement between sleep questionnaire responses and averaged actigraphy data. Forty-eight players wore actigraphy devices nightly and completed daily sleep diaries for 35 consecutive days. After the monitoring period, players completed the Pittsburgh Sleep Quality Index (PSQI). Agreement was assessed using Bland - Altman analysis. Results showed a mean bias of - 60 min between self-reported and objective sleep duration, with wide limits of agreement (-02:09 to +00:15 h), indicating poor agreement. Similar results were observed when comparing self-reported sleep to objective TIB. PSQI responses overestimated average sleep duration for the same time period by 69 min (LoA: -17 to +154 min). Overall, self-reported sleep duration consistently overestimated sleep duration and failed to meet the predefined threshold for acceptable agreement of 30 min. These findings suggest that daily self-report and questionnaire-based sleep estimates may not be reliable proxies for objective sleep data in youth soccer athletes. While subjective methods may still hold practical utility for routine screening, objective tools should be prioritized for sleep monitoring. FAU - Barreira, Joao AU - Barreira J AUID- ORCID: 0000-0002-2652-8685 AD - Research Center in Sports Sciences, Health Sciences and Human Development, CIDESD, University of Maia, Maia, Portugal. FAU - Brito, Joao AU - Brito J AUID- ORCID: 0000-0003-1301-1078 AD - FPF Academy, Portuguese Football Federation, Oeiras, Portugal. AD - CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Oeiras, Portugal. FAU - Yuzo Nakamura, Fabio AU - Yuzo Nakamura F AUID- ORCID: 0000-0002-5336-3652 AD - Research Center in Sports Sciences, Health Sciences and Human Development, CIDESD, University of Maia, Maia, Portugal. FAU - Pimenta, Ricardo AU - Pimenta R AUID- ORCID: 0000-0003-0134-5038 AD - CIPER, Faculdade de Motricidade Humana, Universidade de Lisboa, Oeiras, Portugal. AD - Research Center of the Polytechnic Institute of Maia (N2i), Maia Polytechnic Institute (IPMAIA), Castelo da Maia, Portugal. AD - Department of Rehabilitation and Optimization of Performance (DROP), Futebol Clube Famalicao - Futebol SAD, Famalicao, Portugal. AD - Porto Biomechanics Laboratory, Faculty of Sport, University of Porto, Porto, Portugal. FAU - Figueiredo, Pedro AU - Figueiredo P AUID- ORCID: 0000-0001-5515-3694 AD - Physical Education Department, College of Education, United Arab Emirates University, Al Ain, UAE. LA - eng PT - Journal Article DEP - 20251127 PL - England TA - Sci Med Footb JT - Science & medicine in football JID - 101724288 SB - IM MH - Humans MH - *Sleep Duration MH - Male MH - *Soccer/physiology MH - Actigraphy MH - Adolescent MH - *Self Report MH - Surveys and Questionnaires MH - *Sleep MH - *Athletes OTO - NOTNLM OT - Actigraphy OT - sleep monitoring OT - subjective OT - well-being EDAT- 2025/11/28 06:28 MHDA- 2026/10/25 03:35 CRDT- 2025/11/28 00:02 PHST- 2026/10/25 03:35 [medline] PHST- 2025/11/28 06:28 [pubmed] PHST- 2025/11/28 00:02 [entrez] AID - 10.1080/24733938.2025.2593866 [doi] PST - ppublish SO - Sci Med Footb. 2026 Nov;10(4):459-467. doi: 10.1080/24733938.2025.2593866. Epub 2025 Nov 27. PMID- 41310377 OWN - NLM STAT- MEDLINE DCOM- 20260627 LR - 20261004 IS - 2045-2322 (Electronic) IS - 2045-2322 (Linking) VI - 15 IP - 1 DP - 2025 Nov 27 TI - Predicting gestational diabetes before conception for personalized interpregnancy weight management. PG - 45510 LID - 10.1038/s41598-025-30028-y [doi] LID - 45510 AB - The growing recognition of the importance of interpregnancy care to reduce gestational diabetes mellitus (GDM) risk underscores the importance of effective preventive strategies. However, developing effective systems is still challenging. We aimed to bridge this gap by developing a weight management specific prediction model. This study retrospectively analyzed the data of women who underwent two childbirths across 15 medical facilities, including both primary and tertiary facilities. A derivation cohort was constructed using data from 2009 to 2019 (n = 1,640). Data between 2020 and 2024 was used to construct a separate temporal-validation cohort (n = 293). Using the data from another tertiary center between 2017 and 2023, the geographical-validation cohort was constructed (n = 339). A prediction model for GDM development in the second pregnancy was developed by applying logistic regression analysis using 5 key clinical information. GDM in the second pregnancy occurred in 9.5% (156 of 1,640, derivation), 16.7% (49 of 293, temporal-validation), and 7.7% (26 of 339, geographical-validation). The prediction model demonstrated consistent discrimination across cohorts, with c-statistics of 0.75, 0.80, and 0.79, respectively. Precision-recall analyses, accounting for the low prevalence of GDM, further confirmed performance well above the baseline (0.095 in the derivation cohort), with AUC-PRs of 0.43, 0.47, and 0.41 for the three cohorts. Calibration showed alignment with slopes of 1.04, 0.87, and 0.59 for each cohort. This simple and accurate model supports personalized weight management goals, offering a practical tool to reduce GDM risk in future pregnancies through inter-pregnancy weight management. FAU - Tano, Sho AU - Tano S AD - Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-ku Tsurumai 65, Nagoya, Aichi, 466-8560, Japan. tano.sho.v4@f.mail.nagoya-u.ac.jp. AD - Department of Obstetrics, Perinatal Medical Center, TOYOTA Memorial Hospital, Toyota, Aichi, Japan. tano.sho.v4@f.mail.nagoya-u.ac.jp. FAU - Kotani, Tomomi AU - Kotani T AD - Department of Obstetrics & Gynecology, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, 431-3192, Japan. FAU - Inamura, Tatsuo AU - Inamura T AD - Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-ku Tsurumai 65, Nagoya, Aichi, 466-8560, Japan. AD - Department of Obstetrics, Perinatal Medical Center, TOYOTA Memorial Hospital, Toyota, Aichi, Japan. FAU - Fuma, Kazuya AU - Fuma K AD - Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-ku Tsurumai 65, Nagoya, Aichi, 466-8560, Japan. FAU - Matsuo, Seiko AU - Matsuo S AD - Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-ku Tsurumai 65, Nagoya, Aichi, 466-8560, Japan. FAU - Yoshihara, Masato AU - Yoshihara M AD - Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-ku Tsurumai 65, Nagoya, Aichi, 466-8560, Japan. FAU - Imai, Kenji AU - Imai K AD - Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-ku Tsurumai 65, Nagoya, Aichi, 466-8560, Japan. FAU - Nomoto, Masataka AU - Nomoto M AD - Department of Obstetrics and Gynecology, Ogaki Municipal Hospital, Ogaki, Gifu, Japan. FAU - Moriyama, Yoshinori AU - Moriyama Y AD - Department of Obstetrics and Gynecology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. FAU - Yoshida, Shigeru AU - Yoshida S AD - Kishokai Medical Corporation, Nagoya, Aichi, Japan. FAU - Yamashita, Mamoru AU - Yamashita M AD - Kishokai Medical Corporation, Nagoya, Aichi, Japan. FAU - Kishigami, Yasuyuki AU - Kishigami Y AD - Department of Obstetrics, Perinatal Medical Center, TOYOTA Memorial Hospital, Toyota, Aichi, Japan. FAU - Oguchi, Hidenori AU - Oguchi H AD - Department of Obstetrics, Perinatal Medical Center, TOYOTA Memorial Hospital, Toyota, Aichi, Japan. FAU - Ushida, Takafumi AU - Ushida T AD - Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-ku Tsurumai 65, Nagoya, Aichi, 466-8560, Japan. FAU - Kajiyama, Hiroaki AU - Kajiyama H AD - Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, Showa-ku Tsurumai 65, Nagoya, Aichi, 466-8560, Japan. LA - eng GR - 25K21070/Japan Society for the Promotion of Science/ PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20251127 PL - England TA - Sci Rep JT - Scientific reports JID - 101563288 SB - IM MH - Female MH - Humans MH - *Diabetes, Gestational/epidemiology/diagnosis/prevention & control MH - Pregnancy MH - Retrospective Studies MH - Adult MH - Prediction Algorithms MH - Risk Factors PMC - PMC12749348 OTO - NOTNLM OT - Inter-conception care OT - Obesity OT - Overweight OT - Pre-conception care COIS- Declarations. Competing interests: The authors declare no competing interests. Ethics statement: Prior to the start of the study, ethical approval was granted by the ethics board of Nagoya University Hospital (approval number: 2015-0415) on 4th March 2016, with amendments on 24th June 2021 (22550) and 5th September 2022 (26473). This study was conducted in accordance with the Declaration of Helsinki. We adhered to the Transparent Reporting of a Multivariable Prediction Model for Individual Prognosis or Diagnosis (TRIPOD) guidelines. The requirement for informed consent was waived due to the retrospective nature of the study. EDAT- 2025/11/28 00:26 MHDA- 2026/06/27 10:10 PMCR- 2025/11/27 CRDT- 2025/11/28 00:00 PHST- 2025/07/15 00:00 [received] PHST- 2025/11/20 00:00 [accepted] PHST- 2026/06/27 10:10 [medline] PHST- 2025/11/28 00:26 [pubmed] PHST- 2025/11/28 00:00 [entrez] PHST- 2025/11/27 00:00 [pmc-release] AID - 10.1038/s41598-025-30028-y [pii] AID - 30028 [pii] AID - 10.1038/s41598-025-30028-y [doi] PST - epublish SO - Sci Rep. 2025 Nov 27;15(1):45510. doi: 10.1038/s41598-025-30028-y. PMID- 41308702 OWN - NLM STAT- MEDLINE DCOM- 20251210 LR - 20260623 IS - 1096-0260 (Electronic) IS - 0091-7435 (Linking) VI - 202 DP - 2026 Jan TI - The association between outdoor environmental factors in kindergartens and children's moderate-to-vigorous physical activity: A systematic review and meta-analysis. PG - 108473 LID - S0091-7435(25)00257-9 [pii] LID - 10.1016/j.ypmed.2025.108473 [doi] AB - OBJECTIVES: The kindergarten outdoor environment is considered a key factor influencing children's moderate-to-vigorous physical activity (MVPA). However, existing findings remain inconsistent, with varying criteria and no synthesis. METHODS: Associations came from studies employing two common measurement methods: accelerometry and direct observation. Fixed- or random-effects models were applied to calculate pooled correlation coefficients. A systematic search of six databases for studies published 2000-2024 identified 17 articles, and 9 met the inclusion criteria for meta-analysis. All outdoor environmental factors were standardized and categorized using validated observational systems, enabling consistent evaluation of their associations with children's MVPA and facilitating data integration across methods. RESULTS: Open spaces, natural elements, and "ball and object play" were moderately positively associated with children's MVPA. Fixed equipment showed weak positive association, while sedentary environments showed very weak negative association. Direct observation appeared slightly more sensitive than accelerometry in detecting these associations. CONCLUSIONS: Open spaces, natural elements, and "ball and object play" are associated with higher levels of children's MVPA, while sedentary environments are linked to reduced activity. These findings highlight the importance of designing kindergarten outdoor environments that promote children's physical activity and healthy development. Future studies should consider the influence of measurement tool differences on results. CI - Copyright (c) 2024. Published by Elsevier Inc. FAU - Xu, Zilin AU - Xu Z AD - School of Architecture, Xi'an University of Architecture & Technology, Xi'an, Shaanxi Province 710055, China. FAU - Li, Shuting AU - Li S AD - School of Architecture, Xi'an University of Architecture & Technology, Xi'an, Shaanxi Province 710055, China. Electronic address: lishuting@xauat.edu.cn. FAU - Chu, Hui AU - Chu H AD - School of Architecture, Xi'an University of Architecture & Technology, Xi'an, Shaanxi Province 710055, China. FAU - Zhou, Kun AU - Zhou K AD - School of Architecture, Xi'an University of Architecture & Technology, Xi'an, Shaanxi Province 710055, China. LA - eng PT - Journal Article PT - Meta-Analysis PT - Research Support, Non-U.S. Gov't PT - Systematic Review DEP - 20251125 PL - United States TA - Prev Med JT - Preventive medicine JID - 0322116 SB - IM MH - Humans MH - *Exercise/physiology MH - Accelerometry MH - Child, Preschool MH - *Environment Design MH - *Schools MH - Sedentary Behavior MH - Child OTO - NOTNLM OT - Children OT - Kindergarten OT - MVPA OT - Meta-analysis OT - Outdoor environment COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2025/11/28 00:27 MHDA- 2025/12/11 01:22 CRDT- 2025/11/27 19:11 PHST- 2025/07/18 00:00 [received] PHST- 2025/11/22 00:00 [revised] PHST- 2025/11/24 00:00 [accepted] PHST- 2025/12/11 01:22 [medline] PHST- 2025/11/28 00:27 [pubmed] PHST- 2025/11/27 19:11 [entrez] AID - S0091-7435(25)00257-9 [pii] AID - 10.1016/j.ypmed.2025.108473 [doi] PST - ppublish SO - Prev Med. 2026 Jan;202:108473. doi: 10.1016/j.ypmed.2025.108473. Epub 2025 Nov 25.